# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- AbiH PF14253.6 ORX41450.1 - 0.2 11.5 1.6 0.28 11.0 1.6 1.2 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Rer1 PF03248.13 ORX41450.1 - 0.81 9.4 2.9 13 5.4 0.0 2.2 1 1 1 2 2 2 0 Rer1 family DUF1840 PF08895.11 ORX41450.1 - 3.7 7.9 5.5 0.79 10.1 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) RRN3 PF05327.11 ORX41450.1 - 5.7 5.4 11.8 7 5.1 11.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Drc1-Sld2 PF11719.8 ORX41450.1 - 6.7 6.1 8.3 8.8 5.8 8.3 1.3 1 0 0 1 1 1 0 DNA replication and checkpoint protein Cyclin_N PF00134.23 ORX41546.1 - 2.5e-08 33.7 0.0 3.1e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX41546.1 - 6.4e-08 33.1 0.0 8.3e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Cyclin Vps5 PF09325.10 ORX41547.1 - 5.5e-15 55.6 4.5 1.2e-14 54.4 4.5 1.5 1 1 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ORX41547.1 - 1.4e-09 37.9 0.4 3.3e-09 36.7 0.4 1.6 1 0 0 1 1 1 1 PX domain Ribosomal_S13 PF00416.22 ORX41548.1 - 6.6e-21 75.0 1.7 8.7e-19 68.2 1.7 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX41548.1 - 0.0022 16.9 0.0 0.0023 16.8 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3945 PF13101.6 ORX41548.1 - 0.0057 16.4 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3945) EMP70 PF02990.16 ORX41679.1 - 0.017 13.8 0.2 0.024 13.3 0.2 1.2 1 0 0 1 1 1 0 Endomembrane protein 70 Peptidase_S28 PF05577.12 ORX41679.1 - 0.063 12.1 0.1 0.092 11.5 0.1 1.2 1 0 0 1 1 1 0 Serine carboxypeptidase S28 DUF1644 PF07800.12 ORX41681.1 - 0.0079 16.3 1.4 0.0092 16.1 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1644) OrfB_Zn_ribbon PF07282.11 ORX41681.1 - 0.16 11.9 4.6 1.4 8.9 4.4 2.2 1 1 0 1 1 1 0 Putative transposase DNA-binding domain zf-C2H2 PF00096.26 ORX41730.1 - 4.7e-14 52.0 22.1 4.9e-07 29.8 0.8 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX41730.1 - 2e-08 34.4 19.7 0.00073 20.2 0.2 3.8 3 1 1 4 4 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX41730.1 - 0.00026 20.9 6.2 0.53 10.3 0.0 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX41730.1 - 0.0015 18.9 22.7 0.038 14.4 0.4 4.5 3 1 1 4 4 4 2 Zinc-finger double domain zf-met PF12874.7 ORX41730.1 - 0.0044 17.4 5.0 0.074 13.5 0.3 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX41730.1 - 0.17 12.2 3.7 12 6.3 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.5 ORX41730.1 - 0.65 9.9 3.4 6.3 6.7 0.0 2.6 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-CHY PF05495.12 ORX41730.1 - 0.74 10.4 8.8 0.53 10.8 5.2 2.1 1 1 1 2 2 2 0 CHY zinc finger Evr1_Alr PF04777.13 ORX41730.1 - 0.87 10.1 6.6 7 7.2 3.2 2.4 1 1 1 2 2 2 0 Erv1 / Alr family zinc-ribbons_6 PF07191.12 ORX41730.1 - 0.91 9.6 4.0 5.4 7.1 2.0 2.2 1 1 1 2 2 2 0 zinc-ribbons zf-C2H2_2 PF12756.7 ORX41730.1 - 1.2 9.5 7.8 70 3.8 8.1 2.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) SPX PF03105.19 ORX41730.1 - 2.2 8.1 7.5 3 7.7 7.5 1.4 1 0 0 1 1 1 0 SPX domain Zn-ribbon_8 PF09723.10 ORX41730.1 - 4.7 7.4 7.3 16 5.7 2.9 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Pkinase PF00069.25 ORX41731.1 - 2.1e-61 207.6 0.0 3.4e-61 206.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX41731.1 - 2.5e-34 118.7 0.0 6.7e-34 117.3 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase C1_1 PF00130.22 ORX41731.1 - 5.2e-12 45.5 25.4 2.9e-08 33.5 8.5 2.7 2 1 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 ORX41731.1 - 1.8e-09 38.2 0.1 4.6e-09 36.9 0.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ORX41731.1 - 0.0026 17.1 0.0 0.011 15.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX41731.1 - 0.0043 16.0 0.0 0.0071 15.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ORX41731.1 - 0.012 15.3 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ORX41731.1 - 0.065 12.0 0.0 0.1 11.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PI3_PI4_kinase PF00454.27 ORX41731.1 - 0.081 12.7 0.1 2 8.2 0.0 2.4 2 0 0 2 2 2 0 Phosphatidylinositol 3- and 4-kinase OrfB_Zn_ribbon PF07282.11 ORX41777.1 - 0.0094 15.9 0.5 0.018 15.0 0.5 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 ORX41777.1 - 0.09 12.3 0.1 0.09 12.3 0.1 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding DUF951 PF06107.11 ORX41779.1 - 0.02 14.8 0.0 57 3.7 0.0 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF951) DUF3557 PF12078.8 ORX41779.1 - 0.034 14.1 0.0 51 3.8 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3557) DUF1010 PF06231.11 ORX41779.1 - 0.044 14.3 3.8 6.2 7.4 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1010) FIBP PF05427.11 ORX41824.1 - 0.026 13.8 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) Chitin_synth_2 PF03142.15 ORX41825.1 - 2.3e-29 102.4 5.2 2.5e-29 102.3 5.2 1.0 1 0 0 1 1 1 1 Chitin synthase NTF2 PF02136.20 ORX41934.1 - 3e-07 31.0 0.0 1.7e-05 25.3 0.0 2.6 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain LRR_4 PF12799.7 ORX41934.1 - 0.01 16.3 3.3 0.01 16.3 3.3 1.9 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) CMAS PF02353.20 ORX41934.1 - 0.067 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PAC3 PF10178.9 ORX41935.1 - 5.2e-16 58.6 0.0 7.1e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 DEAD PF00270.29 ORX41936.1 - 1.6e-44 151.8 0.2 2.3e-44 151.2 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX41936.1 - 2.2e-11 44.1 0.8 7.3e-11 42.4 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX41936.1 - 0.006 16.9 0.1 0.021 15.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ORX41936.1 - 0.013 15.0 3.7 0.082 12.4 0.0 2.1 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ORX41936.1 - 0.032 14.6 0.4 0.09 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Met_synt_B12 PF02965.17 ORX41965.1 - 0.27 10.7 0.0 0.38 10.2 0.0 1.1 1 0 0 1 1 1 0 Vitamin B12 dependent methionine synthase, activation domain Pribosyltran PF00156.27 ORX42011.1 - 2.5e-25 88.8 0.0 3.3e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ORX42011.1 - 0.0027 17.2 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.6 ORX42011.1 - 0.003 17.0 0.1 0.0051 16.3 0.1 1.4 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Y_phosphatase2 PF03162.13 ORX42011.1 - 0.11 12.0 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family IPK PF03770.16 ORX42012.1 - 6.1e-40 137.2 0.2 1.4e-39 136.0 0.0 1.7 2 0 0 2 2 2 1 Inositol polyphosphate kinase CysA_C_terminal PF17850.1 ORX42013.1 - 0.12 12.9 0.4 1.6 9.4 0.5 2.4 2 1 0 2 2 2 0 CysA C-terminal regulatory domain Coatomer_WDAD PF04053.14 ORX42014.1 - 6.4e-127 424.3 0.0 2.8e-113 379.3 0.0 3.1 2 1 1 3 3 3 2 Coatomer WD associated region WD40 PF00400.32 ORX42014.1 - 8e-21 74.0 14.7 0.00046 20.9 0.3 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_Mid PF14783.6 ORX42014.1 - 0.12 12.4 0.0 2.4 8.2 0.0 2.9 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region TPR_14 PF13428.6 ORX42014.1 - 0.18 12.7 0.7 12 7.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PH PF00169.29 ORX42075.1 - 0.00078 19.9 0.0 0.0019 18.7 0.0 1.7 1 0 0 1 1 1 1 PH domain OrfB_Zn_ribbon PF07282.11 ORX42108.1 - 0.029 14.3 0.4 0.084 12.8 0.4 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Psb28 PF03912.14 ORX42108.1 - 0.052 13.8 0.1 0.27 11.5 0.1 2.2 1 0 0 1 1 1 0 Psb28 protein HTH_16 PF12645.7 ORX42109.1 - 0.11 12.5 0.0 0.4 10.7 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain YEATS PF03366.16 ORX42110.1 - 1.6e-17 63.2 0.0 2.8e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 YEATS family BET PF17035.5 ORX42110.1 - 0.001 19.2 0.3 0.0024 18.0 0.3 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DDE_3 PF13358.6 ORX42111.1 - 0.00015 21.5 0.3 0.00023 20.9 0.2 1.4 1 1 0 1 1 1 1 DDE superfamily endonuclease Histone_H2A_C PF16211.5 ORX42170.1 - 4.1e-20 71.2 1.8 7.8e-20 70.3 1.8 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ORX42170.1 - 7.5e-18 65.2 0.0 9.6e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX42170.1 - 0.00088 19.5 0.0 0.0012 19.1 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 ORX42170.1 - 0.12 12.3 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 LcrG protein Ribosomal_L21e PF01157.18 ORX42174.1 - 3.7e-49 164.8 3.8 6.4e-49 164.0 3.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L21e LRS4 PF10422.9 ORX42174.1 - 0.064 12.8 0.0 0.078 12.5 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Brr6_like_C_C PF10104.9 ORX42175.1 - 1e-43 148.3 1.9 1.2e-43 148.0 1.9 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain YlaH PF14036.6 ORX42175.1 - 0.091 13.1 2.3 0.28 11.5 0.1 2.2 2 0 0 2 2 2 0 YlaH-like protein DUF1685 PF07939.11 ORX42178.1 - 0.0073 16.0 0.1 2.7 7.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1685) NTF2 PF02136.20 ORX42179.1 - 2e-07 31.6 0.0 9.1e-06 26.2 0.0 3.0 2 1 0 2 2 2 1 Nuclear transport factor 2 (NTF2) domain LRR_9 PF14580.6 ORX42179.1 - 1.3e-05 24.8 0.1 2.7e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ORX42179.1 - 0.0073 16.7 5.6 0.0073 16.7 2.1 2.3 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) RRM_9 PF18444.1 ORX42179.1 - 0.065 13.1 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif LRR_8 PF13855.6 ORX42179.1 - 0.13 12.1 3.2 0.49 10.2 3.3 2.0 1 1 0 1 1 1 0 Leucine rich repeat PAC3 PF10178.9 ORX42180.1 - 1.1e-17 63.9 0.0 1.4e-17 63.6 0.0 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 DEAD PF00270.29 ORX42181.1 - 2.3e-44 151.2 0.2 3.7e-44 150.6 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX42181.1 - 6.7e-21 74.7 0.0 2e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX42181.1 - 4.3e-17 62.1 0.0 1e-16 60.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX42181.1 - 5.3e-11 42.8 1.2 1.1e-10 41.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX42181.1 - 0.007 16.6 0.1 0.03 14.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ORX42181.1 - 0.022 14.3 3.6 0.13 11.7 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ORX42181.1 - 0.061 13.7 0.0 0.14 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Tube PF17212.3 ORX42249.1 - 0.021 14.9 0.1 0.035 14.2 0.1 1.3 1 0 0 1 1 1 0 Tail tubular protein DUF1574 PF07611.11 ORX42249.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) GHL13 PF14883.6 ORX42249.1 - 0.14 11.2 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 Chromo PF00385.24 ORX42250.1 - 1.2e-11 44.4 2.2 2e-11 43.6 2.2 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 ORX42250.1 - 0.00066 19.5 1.0 0.0012 18.7 1.0 1.4 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain RVT_1 PF00078.27 ORX42252.1 - 8.5e-05 22.2 0.0 8.7e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Dev_Cell_Death PF10539.9 ORX42252.1 - 0.18 11.7 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Development and cell death domain MAAL_N PF05034.13 ORX42266.1 - 0.086 12.5 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase N-terminus zf-RVT PF13966.6 ORX42267.1 - 1.3e-09 38.7 0.5 1.3e-09 38.7 0.5 2.0 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 ORX42267.1 - 3.8e-05 23.3 0.0 5.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-RVT PF13966.6 ORX42270.1 - 7.4e-11 42.6 1.2 8.9e-11 42.4 1.2 1.0 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase His_Me_b4a2 PF18275.1 ORX42270.1 - 0.1 12.7 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain DZR PF12773.7 ORX42318.1 - 0.011 15.8 2.6 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-CCHC_6 PF15288.6 ORX42318.1 - 0.037 13.9 6.9 1.6 8.6 0.7 2.5 2 0 0 2 2 2 0 Zinc knuckle Prok-RING_1 PF14446.6 ORX42318.1 - 0.053 13.5 6.5 0.34 10.9 1.2 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 7tm_6 PF02949.20 ORX42318.1 - 0.063 12.4 0.1 0.093 11.8 0.1 1.2 1 0 0 1 1 1 0 7tm Odorant receptor zf_C2H2_13 PF18508.1 ORX42318.1 - 0.13 11.9 1.0 0.29 10.8 0.0 1.9 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_6 PF18585.1 ORX42318.1 - 0.2 11.5 4.3 8.1 6.4 0.1 2.5 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 zf-Mss51 PF13824.6 ORX42318.1 - 0.91 9.7 8.4 34 4.6 6.8 2.7 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 OrfB_Zn_ribbon PF07282.11 ORX42318.1 - 0.91 9.5 2.9 15 5.6 0.2 2.5 2 0 0 2 2 2 0 Putative transposase DNA-binding domain zf-IS66 PF13005.7 ORX42318.1 - 4 7.9 6.8 5.2 7.6 1.0 2.7 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Zn-ribbon_8 PF09723.10 ORX42318.1 - 4.1 7.6 8.3 7.1 6.8 1.0 2.7 2 1 0 2 2 2 0 Zinc ribbon domain YacG PF03884.14 ORX42318.1 - 5.9 6.7 8.3 0.62 9.8 1.1 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG DUF5595 PF18077.1 ORX42321.1 - 0.37 10.9 3.7 0.93 9.6 0.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) OmpH PF03938.14 ORX42321.1 - 3.3 8.1 49.7 0.034 14.5 7.0 3.9 3 1 1 4 4 4 0 Outer membrane protein (OmpH-like) WD40 PF00400.32 ORX42322.1 - 4e-11 43.3 9.8 0.02 15.7 0.0 5.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX42322.1 - 6e-06 26.5 0.0 8.9 6.7 0.0 5.0 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX42322.1 - 0.0069 15.7 0.0 0.013 14.9 0.0 1.4 2 0 0 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 ORX42322.1 - 0.047 14.2 0.1 10 6.8 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain Nucleoporin_N PF08801.11 ORX42322.1 - 0.11 11.2 0.0 11 4.7 0.0 2.4 2 0 0 2 2 2 0 Nup133 N terminal like MMR_HSR1 PF01926.23 ORX42323.1 - 6.1e-22 77.9 0.0 8.8e-22 77.4 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX42323.1 - 1.3e-07 31.2 0.0 1.7e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX42323.1 - 3.4e-07 30.3 0.0 5.8e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase SRPRB PF09439.10 ORX42323.1 - 1.6e-06 27.6 0.0 3.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 ORX42323.1 - 9.5e-06 25.8 0.0 0.073 13.1 0.1 2.2 1 1 1 2 2 2 2 Dynamin family Septin PF00735.18 ORX42323.1 - 0.00019 20.9 0.2 0.01 15.1 0.1 2.7 1 1 1 2 2 2 1 Septin GTP_EFTU PF00009.27 ORX42323.1 - 0.0014 18.2 0.0 0.78 9.2 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Roc PF08477.13 ORX42323.1 - 0.0021 18.3 0.0 0.0027 17.9 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_14 PF13173.6 ORX42323.1 - 0.0037 17.3 0.0 0.0079 16.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ORX42323.1 - 0.0043 16.3 0.0 1.9 7.6 0.0 2.1 2 0 0 2 2 2 2 NB-ARC domain AAA_22 PF13401.6 ORX42323.1 - 0.01 16.1 0.0 0.026 14.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ORX42323.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ORX42323.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ORX42323.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain Ras PF00071.22 ORX42323.1 - 0.13 11.8 0.0 0.34 10.5 0.0 1.6 2 0 0 2 2 2 0 Ras family TPR_1 PF00515.28 ORX42324.1 - 4.4e-10 38.9 9.3 0.00076 19.2 0.1 6.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX42324.1 - 2.8e-09 36.4 17.7 0.00062 19.7 0.5 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX42324.1 - 1.2e-07 31.9 20.3 0.0041 17.8 0.6 7.1 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX42324.1 - 1.6e-06 27.9 9.2 0.24 11.7 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX42324.1 - 7.1e-06 26.4 6.7 0.21 12.1 0.4 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX42324.1 - 0.00038 20.6 10.0 2.6 8.3 0.1 5.8 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ORX42324.1 - 0.00048 20.2 8.4 0.089 13.0 1.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX42324.1 - 0.0054 17.0 7.8 25 5.5 0.0 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX42324.1 - 0.032 13.9 1.7 33 4.3 0.0 4.6 4 0 0 4 4 4 0 TPR repeat zf-C3Hc3H PF13891.6 ORX42324.1 - 0.11 12.9 0.2 0.36 11.2 0.2 1.9 1 0 0 1 1 1 0 Potential DNA-binding domain TPR_16 PF13432.6 ORX42324.1 - 0.58 10.9 15.6 1.1 9.9 1.5 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX42324.1 - 2.4 8.3 4.4 0.87 9.7 0.1 2.6 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 ORX42324.1 - 2.6 8.9 11.6 2.3 9.0 0.3 5.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX42324.1 - 3 7.9 6.1 35 4.5 0.7 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX42324.1 - 4.3 7.7 16.0 1.8 8.9 0.3 6.1 7 1 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX42324.1 - 5.8 7.2 6.8 82 3.6 0.1 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Glycos_transf_1 PF00534.20 ORX42325.1 - 9.6e-19 67.6 0.0 1.9e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX42325.1 - 3.5e-12 46.9 0.0 8.7e-12 45.6 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ORX42325.1 - 5.7e-11 42.6 0.2 2.4e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Starch synthase catalytic domain Glyco_transf_4 PF13439.6 ORX42325.1 - 1.9e-05 24.8 0.3 0.0077 16.2 0.1 3.5 3 1 0 3 3 3 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX42325.1 - 0.00018 22.0 0.3 0.0078 16.7 0.1 3.1 3 0 0 3 3 3 1 Glycosyl transferase 4-like domain DUF3123 PF11321.8 ORX42325.1 - 0.03 15.0 1.4 20 5.9 1.9 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) Sld5 PF05916.11 ORX42326.1 - 3e-23 82.3 1.4 4e-23 82.0 1.4 1.2 1 0 0 1 1 1 1 GINS complex protein OSR1_C PF12202.8 ORX42327.1 - 0.036 14.3 0.3 0.11 12.8 0.2 2.0 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain HTH_32 PF13565.6 ORX42357.1 - 3.5e-07 30.8 0.0 4.2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX42357.1 - 3.4e-05 23.8 0.0 8.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 ORX42357.1 - 4.9e-05 23.4 0.1 7.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX42357.1 - 0.00093 18.9 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX42357.1 - 0.051 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) OrfB_Zn_ribbon PF07282.11 ORX42359.1 - 0.0025 17.7 0.1 0.0038 17.1 0.1 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 ORX42359.1 - 0.023 14.2 1.0 0.032 13.8 0.1 1.6 2 0 0 2 2 2 0 TFIIB zinc-binding MAT1 PF06391.13 ORX42360.1 - 3.9e-18 66.0 12.0 4.6e-18 65.8 12.0 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 DUF4407 PF14362.6 ORX42360.1 - 1.3 8.3 9.8 2.2 7.6 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4381 PF14316.6 ORX42360.1 - 2.3 8.5 7.5 1.3 9.3 5.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) Selenoprotein_S PF06936.11 ORX42360.1 - 2.9 7.7 11.1 4.6 7.0 11.1 1.3 1 0 0 1 1 1 0 Selenoprotein S (SelS) MAT1 PF06391.13 ORX42361.1 - 4.3e-24 85.5 3.8 6e-24 85.0 3.8 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 ORX42361.1 - 7.6e-18 64.1 9.0 1.6e-17 63.1 9.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX42361.1 - 6.5e-05 22.8 10.0 0.0007 19.5 10.7 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX42361.1 - 6.9e-05 22.6 9.0 0.00037 20.3 9.6 1.8 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX42361.1 - 0.00029 20.6 7.7 0.0013 18.6 3.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ORX42361.1 - 0.00061 19.5 5.5 0.074 12.9 2.3 2.2 2 0 0 2 2 2 2 RING/Ubox like zinc-binding domain PADR1 PF08063.12 ORX42361.1 - 0.0014 18.4 5.6 0.0045 16.7 1.0 2.2 2 0 0 2 2 2 1 PADR1 (NUC008) domain DUF3797 PF12677.7 ORX42361.1 - 0.0023 17.8 3.5 0.0031 17.3 0.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3797) zf-UDP PF14569.6 ORX42361.1 - 0.0075 16.4 4.7 0.091 12.9 0.4 2.2 1 1 1 2 2 2 1 Zinc-binding RING-finger zf-RING_2 PF13639.6 ORX42361.1 - 0.026 14.8 9.4 0.073 13.4 9.6 1.6 1 1 1 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 ORX42361.1 - 0.08 12.8 11.5 1.6 8.7 11.8 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Zn-ribbon_8 PF09723.10 ORX42361.1 - 0.13 12.4 7.2 1.3 9.2 0.1 2.7 2 1 0 2 2 2 0 Zinc ribbon domain zf-RING_UBOX PF13445.6 ORX42361.1 - 0.14 12.2 10.4 0.24 11.5 10.4 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zinc_ribbon_9 PF14369.6 ORX42361.1 - 0.59 10.4 5.8 3.3 8.1 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon Pribosyltran PF00156.27 ORX42362.1 - 1.6e-16 60.2 0.1 2e-16 59.9 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ORX42362.1 - 0.0063 16.0 0.0 0.0082 15.6 0.0 1.3 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase DUF1256 PF06866.11 ORX42362.1 - 0.088 12.2 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1256) Propeptide_C1 PF08127.13 ORX42362.1 - 0.09 12.7 0.1 1.5 8.8 0.0 2.2 2 0 0 2 2 2 0 Peptidase family C1 propeptide VASt PF16016.5 ORX42363.1 - 1.2e-29 103.8 0.2 3.5e-29 102.2 0.1 1.9 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 ORX42363.1 - 6.6e-15 55.5 0.4 7.6e-14 52.1 0.1 2.4 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 ORX42363.1 - 5.3e-11 42.7 2.9 9.3e-11 41.9 2.9 1.3 1 0 0 1 1 1 1 BAR domain of APPL family GRAM PF02893.20 ORX42363.1 - 4.3e-05 23.4 0.0 9.7e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 GRAM domain BAR PF03114.18 ORX42363.1 - 1.4 8.5 6.2 0.12 12.0 0.9 1.8 2 0 0 2 2 2 0 BAR domain TAP42 PF04177.12 ORX42364.1 - 6.7e-87 291.6 14.2 7.8e-87 291.4 14.2 1.0 1 0 0 1 1 1 1 TAP42-like family BNIP3 PF06553.12 ORX42364.1 - 0.13 11.9 1.5 0.23 11.1 1.0 1.6 1 1 0 1 1 1 0 BNIP3 Spectrin_like PF18373.1 ORX42364.1 - 0.2 11.8 3.4 0.16 12.1 0.5 2.4 2 0 0 2 2 2 0 Spectrin like domain SLX9 PF15341.6 ORX42364.1 - 2.7 8.4 10.1 0.9 9.9 6.7 1.9 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 MFS_1 PF07690.16 ORX42365.1 - 2.9e-35 121.8 45.8 6.1e-31 107.6 27.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4006 PF13179.6 ORX42365.1 - 0.14 12.1 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF4006) THOC7 PF05615.13 ORX42366.1 - 9.4e-14 51.8 4.5 9.4e-14 51.8 4.5 1.9 2 1 0 2 2 2 1 Tho complex subunit 7 COMM_domain PF07258.14 ORX42366.1 - 0.0068 16.5 1.1 0.024 14.8 0.4 2.3 1 1 1 2 2 2 1 COMM domain Tho2 PF11262.8 ORX42366.1 - 0.78 8.9 10.9 0.071 12.3 4.0 2.0 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF2756 PF10956.8 ORX42366.1 - 6.3 7.4 11.6 11 6.6 3.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) OrfB_Zn_ribbon PF07282.11 ORX42367.1 - 7.3e-08 32.2 0.1 1e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-CCHC_6 PF15288.6 ORX42368.1 - 0.00019 21.2 2.7 0.00048 19.9 2.7 1.7 1 0 0 1 1 1 1 Zinc knuckle SRP19 PF01922.17 ORX42370.1 - 1e-28 100.1 0.1 2.1e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 SRP19 protein DUF5595 PF18077.1 ORX42370.1 - 0.072 13.2 0.2 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) CoA_transf_3 PF02515.17 ORX42371.1 - 1.7e-28 99.8 0.1 8.2e-28 97.6 0.1 1.8 1 1 0 1 1 1 1 CoA-transferase family III AAA_11 PF13086.6 ORX42415.1 - 1.3 8.8 15.8 2.5 7.8 15.8 1.4 1 0 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.12 ORX42415.1 - 1.4 8.7 19.9 2.7 7.7 19.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3808 PF10300.9 ORX42416.1 - 9.1e-30 103.8 3.9 2.3e-29 102.5 3.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX42416.1 - 0.00084 19.3 0.5 2.6 8.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat Barwin PF00967.17 ORX42417.1 - 1e-06 28.6 0.5 1.5e-06 28.0 0.5 1.3 1 0 0 1 1 1 1 Barwin family DPBB_1 PF03330.18 ORX42417.1 - 3.6e-05 24.0 0.1 5.7e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 Lytic transglycolase ATP19 PF11022.8 ORX42418.1 - 2e-26 92.2 0.0 2.2e-26 92.0 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K PsbJ PF01788.17 ORX42418.1 - 0.17 11.7 1.4 0.24 11.3 1.4 1.2 1 0 0 1 1 1 0 PsbJ Arm PF00514.23 ORX42419.1 - 9.2e-85 276.4 8.5 1.6e-12 47.0 0.0 8.7 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 ORX42419.1 - 4.7e-24 83.7 0.1 1.8e-22 78.6 0.5 2.8 3 0 0 3 3 3 1 Atypical Arm repeat IBB PF01749.20 ORX42419.1 - 2.7e-23 82.2 3.2 3.6e-22 78.6 4.1 2.2 2 0 0 2 2 2 1 Importin beta binding domain HEAT_2 PF13646.6 ORX42419.1 - 1.4e-21 76.7 0.0 4.6e-09 36.5 0.0 6.1 3 1 2 6 6 6 4 HEAT repeats HEAT_EZ PF13513.6 ORX42419.1 - 4.8e-19 68.5 0.2 2.5e-09 37.4 0.0 6.2 4 3 3 7 7 7 5 HEAT-like repeat HEAT PF02985.22 ORX42419.1 - 1.3e-17 62.4 0.1 5.3e-06 26.2 0.0 6.8 7 0 0 7 7 7 3 HEAT repeat Adaptin_N PF01602.20 ORX42419.1 - 1.4e-06 27.2 0.0 0.00032 19.4 0.0 2.4 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 ORX42419.1 - 1.7e-05 24.4 0.0 0.083 12.3 0.0 3.4 2 1 1 3 3 3 2 Armadillo-like V-ATPase_H_C PF11698.8 ORX42419.1 - 3.6e-05 23.8 0.0 0.2 11.8 0.0 4.2 3 1 1 4 4 4 1 V-ATPase subunit H RICTOR_V PF14668.6 ORX42419.1 - 0.00012 22.3 0.1 0.044 14.0 0.0 4.2 3 1 1 4 4 4 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 ORX42419.1 - 0.0014 18.6 0.0 0.097 12.7 0.0 3.0 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain CTNNBL PF08216.11 ORX42419.1 - 0.0054 16.9 0.5 9.2 6.5 0.0 5.4 8 1 1 9 9 8 1 Catenin-beta-like, Arm-motif containing nuclear HEAT_PBS PF03130.16 ORX42419.1 - 0.0061 17.1 0.1 0.65 10.8 0.0 3.4 3 0 0 3 3 3 1 PBS lyase HEAT-like repeat NopRA1 PF16201.5 ORX42419.1 - 0.017 14.7 0.0 20 4.7 0.0 3.7 2 2 2 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 Cnd1 PF12717.7 ORX42419.1 - 0.03 14.4 0.0 11 6.1 0.0 2.6 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 zinc_ribbon_6 PF14599.6 ORX42420.1 - 2.1e-24 85.3 4.4 2.1e-24 85.3 4.4 4.8 2 1 2 5 5 5 1 Zinc-ribbon zf-CHY PF05495.12 ORX42420.1 - 7.2e-19 68.0 27.6 7.2e-19 68.0 27.6 3.9 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 ORX42420.1 - 5.5e-08 33.0 9.5 5.5e-08 33.0 9.5 5.9 3 2 3 6 6 6 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX42420.1 - 0.00036 20.5 3.6 0.00036 20.5 3.6 6.0 4 4 0 4 4 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX42420.1 - 0.0029 17.4 11.5 0.0029 17.4 11.5 6.2 3 3 3 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX42420.1 - 0.023 14.7 13.0 0.023 14.7 13.0 7.4 3 3 4 7 7 7 0 zinc-RING finger domain DUF202 PF02656.15 ORX42421.1 - 5.2e-14 52.4 4.2 5.2e-14 52.4 4.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) zf-CCHC PF00098.23 ORX42422.1 - 1.5e-05 24.9 12.1 0.0039 17.2 1.4 2.5 2 0 0 2 2 2 2 Zinc knuckle Exo_endo_phos_2 PF14529.6 ORX42422.1 - 0.0004 20.2 0.4 0.00099 18.9 0.4 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ORX42422.1 - 0.0018 17.9 0.4 0.0038 16.8 0.4 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-CCHC_4 PF14392.6 ORX42422.1 - 0.042 13.6 5.4 0.17 11.6 0.1 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 ORX42430.1 - 0.053 13.4 10.0 1 9.2 1.9 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-Mss51 PF13824.6 ORX42430.1 - 0.054 13.6 0.8 12 6.1 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 GATA PF00320.27 ORX42430.1 - 0.13 11.9 1.7 13 5.5 0.1 2.3 2 0 0 2 2 2 0 GATA zinc finger zf-CCCH_6 PF18585.1 ORX42430.1 - 0.16 11.9 7.2 1.4 8.8 0.2 2.5 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DZR PF12773.7 ORX42430.1 - 0.21 11.6 5.8 5.5 7.1 0.7 2.3 2 0 0 2 2 2 0 Double zinc ribbon zf-CCHC_4 PF14392.6 ORX42430.1 - 2.1 8.1 4.9 0.36 10.6 0.3 1.9 2 0 0 2 2 2 0 Zinc knuckle OrfB_Zn_ribbon PF07282.11 ORX42432.1 - 3 7.8 7.5 1.2 9.1 4.1 2.1 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Peptidase_C42 PF05533.12 ORX42433.1 - 0.09 12.8 0.0 0.098 12.7 0.0 1.1 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 GATase_2 PF00310.21 ORX42434.1 - 2.5e-179 596.4 0.0 3.3e-179 596.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 ORX42434.1 - 6.8e-154 512.4 0.1 1.8e-153 511.0 0.0 1.7 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 ORX42434.1 - 4.2e-114 380.8 0.0 2.4e-113 378.3 0.0 2.0 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 ORX42434.1 - 5.7e-87 290.2 3.3 1e-86 289.4 3.3 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 ORX42434.1 - 2.8e-27 95.7 0.2 1.6e-26 93.2 0.2 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ORX42434.1 - 3.5e-23 81.5 0.5 8.4e-23 80.3 0.5 1.7 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_3 PF13738.6 ORX42434.1 - 3e-08 33.3 0.6 0.00079 18.8 0.0 3.4 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX42434.1 - 3.1e-07 30.5 0.0 1.1e-06 28.7 0.0 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX42434.1 - 4.4e-07 29.8 0.3 0.0058 16.3 0.1 2.9 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox PF00070.27 ORX42434.1 - 5.8e-07 30.0 0.2 0.00011 22.7 0.1 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX42434.1 - 1.5e-05 24.3 0.5 0.0021 17.2 0.0 2.9 3 0 0 3 3 2 1 FAD binding domain HI0933_like PF03486.14 ORX42434.1 - 6.6e-05 21.8 2.5 8.5e-05 21.4 0.1 2.4 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.6 ORX42434.1 - 0.00024 21.5 0.3 0.8 10.2 0.1 3.7 3 0 0 3 3 3 1 Putative NAD(P)-binding FAD_oxidored PF12831.7 ORX42434.1 - 0.00043 19.8 0.1 0.0013 18.2 0.1 1.8 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ORX42434.1 - 0.00043 19.7 0.0 0.0008 18.8 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 ORX42434.1 - 0.0049 16.1 0.0 0.014 14.7 0.0 1.7 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 ORX42434.1 - 0.0062 15.9 0.6 0.057 12.7 0.1 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_Gly3P_dh_N PF01210.23 ORX42434.1 - 0.016 15.2 0.0 0.12 12.4 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 ORX42434.1 - 0.023 13.8 1.4 0.23 10.5 0.2 2.7 2 1 1 3 3 3 0 Glucose inhibited division protein A FMN_dh PF01070.18 ORX42434.1 - 0.046 12.7 0.5 0.44 9.5 0.5 2.5 3 0 0 3 3 3 0 FMN-dependent dehydrogenase Thi4 PF01946.17 ORX42434.1 - 0.1 11.8 1.8 0.17 11.1 0.0 2.2 3 0 0 3 3 3 0 Thi4 family GATase_6 PF13522.6 ORX42434.1 - 0.11 12.7 0.0 0.32 11.2 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain NAD_binding_2 PF03446.15 ORX42434.1 - 0.12 12.5 0.1 0.61 10.3 0.1 2.3 2 0 0 2 2 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase ATP_synt_H PF05493.13 ORX42435.1 - 3.1e-21 75.6 6.8 3.8e-21 75.3 6.8 1.1 1 0 0 1 1 1 1 ATP synthase subunit H Flavi_NS4A PF01350.17 ORX42435.1 - 0.041 13.8 0.9 0.048 13.6 0.9 1.1 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Spore_YunB PF09560.10 ORX42435.1 - 0.082 12.9 0.0 0.091 12.8 0.0 1.2 1 0 0 1 1 1 0 Sporulation protein YunB (Spo_YunB) ARL6IP6 PF15062.6 ORX42435.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix CLTH PF10607.9 ORX42436.1 - 6.9e-35 120.1 0.2 9.5e-35 119.7 0.2 1.2 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ORX42436.1 - 5.6e-10 38.8 0.1 1.3e-09 37.6 0.1 1.7 1 0 0 1 1 1 1 LisH AAA_33 PF13671.6 ORX42437.1 - 1.6e-10 41.3 0.0 2.1e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain OrfB_Zn_ribbon PF07282.11 ORX42506.1 - 0.00025 20.9 0.1 0.00045 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TMEM223 PF14640.6 ORX42507.1 - 5.3e-07 30.0 0.0 0.017 15.3 0.0 2.2 1 1 1 2 2 2 2 Transmembrane protein 223 Peptidase_M1 PF01433.20 ORX42508.1 - 8e-47 159.6 0.0 1.1e-46 159.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ORX42508.1 - 4.6e-40 136.2 0.0 8.1e-40 135.4 0.0 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ORX42508.1 - 3.5e-30 105.6 0.4 4.9e-30 105.1 0.4 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Aldo_ket_red PF00248.21 ORX42509.1 - 1.2e-40 139.6 0.0 1.4e-40 139.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family OSR1_C PF12202.8 ORX42511.1 - 0.04 14.1 0.2 0.13 12.5 0.1 1.9 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain Fer4_2 PF12797.7 ORX42512.1 - 0.088 12.9 0.5 0.17 12.1 0.5 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain Fer4_2 PF12797.7 ORX42513.1 - 0.045 13.9 0.9 0.088 12.9 0.9 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain M-factor PF03855.13 ORX42514.1 - 0.13 12.4 0.6 41 4.4 0.0 3.0 3 0 0 3 3 3 0 M-factor Methyltransf_FA PF12248.8 ORX42514.1 - 0.83 10.0 5.7 32 4.9 0.0 3.4 3 0 0 3 3 3 0 Farnesoic acid 0-methyl transferase Sortilin-Vps10 PF15902.5 ORX42516.1 - 0 1326.8 25.0 2.3e-139 465.1 4.2 3.1 3 0 0 3 3 3 3 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 ORX42516.1 - 1.3e-127 422.7 34.8 1.2e-46 159.1 5.8 4.4 4 0 0 4 4 4 4 Sortilin, neurotensin receptor 3, C-terminal BNR_2 PF13088.6 ORX42516.1 - 0.00022 20.6 17.1 0.11 11.8 0.1 7.8 7 4 2 9 9 9 3 BNR repeat-like domain PSII_BNR PF14870.6 ORX42516.1 - 0.00074 18.9 13.3 0.016 14.5 0.2 5.9 5 1 0 5 5 5 2 Photosynthesis system II assembly factor YCF48 CHB_HEX_C PF03174.13 ORX42516.1 - 0.047 13.7 4.7 76 3.4 0.1 5.6 6 0 0 6 6 6 0 Chitobiase/beta-hexosaminidase C-terminal domain BNR PF02012.20 ORX42516.1 - 1.1 9.6 90.6 0.66 10.2 0.2 17.1 19 0 0 19 19 19 0 BNR/Asp-box repeat Tat PF00539.18 ORX42516.1 - 4.5 7.5 5.2 40 4.4 0.1 3.1 3 0 0 3 3 3 0 Transactivating regulatory protein (Tat) Proteasome PF00227.26 ORX42518.1 - 3e-28 98.6 0.0 3.5e-28 98.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit WWE PF02825.20 ORX42519.1 - 0.03 14.9 0.0 0.047 14.3 0.0 1.5 1 0 0 1 1 1 0 WWE domain OrfB_Zn_ribbon PF07282.11 ORX42584.1 - 1.6e-09 37.5 0.4 5.8e-09 35.7 0.4 2.0 1 0 0 1 1 1 1 Putative transposase DNA-binding domain RNHCP PF12647.7 ORX42584.1 - 0.019 15.0 0.8 0.019 15.0 0.8 2.1 2 0 0 2 2 2 0 RNHCP domain DZR PF12773.7 ORX42584.1 - 0.052 13.6 1.0 0.12 12.4 1.0 1.6 1 0 0 1 1 1 0 Double zinc ribbon PAS_4 PF08448.10 ORX42584.1 - 0.18 12.1 2.0 4.6 7.5 0.4 2.7 1 1 2 3 3 3 0 PAS fold bZIP_Maf PF03131.17 ORX42584.1 - 4 8.0 17.3 2.1 8.9 14.3 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor zf_C2H2_13 PF18508.1 ORX42586.1 - 0.083 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Zinc finger domain Prok-RING_1 PF14446.6 ORX42586.1 - 0.095 12.6 2.5 0.12 12.3 0.4 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Pribosyltran_N PF13793.6 ORX42588.1 - 5.3e-48 161.8 1.4 2.1e-46 156.6 0.2 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 ORX42588.1 - 1.3e-44 152.4 5.4 7.8e-37 127.1 1.2 2.7 2 1 1 3 3 3 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 ORX42588.1 - 4.9e-14 52.1 1.2 4.9e-14 52.1 1.2 2.1 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPF0181 PF03701.14 ORX42588.1 - 0.028 14.0 0.4 0.3 10.7 0.1 2.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0181) Na_Ca_ex PF01699.24 ORX42589.1 - 3.9e-47 160.0 37.6 2.8e-27 95.5 13.8 2.8 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF3348 PF11828.8 ORX42589.1 - 0.047 13.4 1.4 0.075 12.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Ribosomal_L1 PF00687.21 ORX42590.1 - 2.8e-46 157.8 1.6 3.3e-46 157.6 1.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family CIAPIN1 PF05093.13 ORX42590.1 - 0.08 13.5 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis B12D PF06522.11 ORX42591.1 - 8e-21 73.6 0.0 9.8e-21 73.3 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Thaumatin PF00314.17 ORX42592.1 - 3.9e-48 163.9 19.0 2.9e-47 161.1 19.0 1.9 1 1 0 1 1 1 1 Thaumatin family TMEM190 PF15431.6 ORX42592.1 - 0.012 15.8 0.2 0.026 14.7 0.2 1.5 1 0 0 1 1 1 0 Transmembrane protein 190 NGP1NT PF08153.12 ORX42593.1 - 1e-53 180.9 0.5 1e-53 180.9 0.5 2.0 2 0 0 2 2 2 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 ORX42593.1 - 9.8e-17 61.1 0.1 6.9e-13 48.7 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX42593.1 - 5.8e-05 22.7 0.0 0.0004 19.9 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ORX42593.1 - 0.00012 21.6 0.1 0.084 12.3 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX42593.1 - 0.0021 18.0 0.0 0.0062 16.4 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 ORX42593.1 - 0.003 17.1 0.0 0.2 11.2 0.0 3.2 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain MCR_C PF04609.12 ORX42593.1 - 0.12 11.4 0.2 0.39 9.7 0.0 1.8 2 0 0 2 2 2 0 Methyl-coenzyme M reductase operon protein C Dynamin_N PF00350.23 ORX42593.1 - 0.53 10.3 13.2 3.4 7.7 0.0 4.5 4 2 1 5 5 5 0 Dynamin family Sugar_tr PF00083.24 ORX42594.1 - 5e-90 302.5 19.2 1.2e-89 301.2 19.2 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX42594.1 - 6.1e-29 101.0 34.4 3.6e-22 78.8 13.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX42594.1 - 9e-08 31.8 7.6 9e-08 31.8 7.6 2.2 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ORX42594.1 - 0.0061 14.9 12.6 0.024 12.9 6.6 3.3 1 1 1 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF639 PF04842.12 ORX42594.1 - 0.41 10.0 3.0 0.52 9.7 1.0 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF639) NDC10_II PF16787.5 ORX42597.1 - 0.027 13.5 0.0 0.027 13.5 0.0 1.0 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Ribosomal_S11 PF00411.19 ORX42598.1 - 3e-46 156.4 1.4 4.2e-46 155.9 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S11 CK_II_beta PF01214.18 ORX42599.1 - 1.9e-69 233.1 0.0 2.2e-69 232.9 0.0 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit DUF3797 PF12677.7 ORX42599.1 - 0.047 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3797) PIGA PF08288.12 ORX42600.1 - 3.7e-46 155.6 0.4 8.5e-46 154.5 0.4 1.6 1 0 0 1 1 1 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 ORX42600.1 - 2e-28 99.5 0.2 3e-28 98.9 0.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ORX42600.1 - 2.2e-24 85.9 0.0 4.7e-24 84.9 0.0 1.6 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX42600.1 - 2.1e-20 73.5 0.2 4.8e-20 72.4 0.1 1.6 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ORX42600.1 - 2.3e-09 37.9 0.0 4e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 ORX42600.1 - 1.7e-06 28.1 0.1 2.5e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like Transposase_31 PF04754.12 ORX42602.1 - 0.11 12.1 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 Putative transposase, YhgA-like Cluap1 PF10234.9 ORX42603.1 - 0.0017 17.8 1.6 0.0017 17.8 1.6 2.1 2 0 0 2 2 2 1 Clusterin-associated protein-1 SID PF11778.8 ORX42603.1 - 0.1 12.7 0.3 8.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Septation initiation Cnl2_NKP2 PF09447.10 ORX42603.1 - 0.11 12.7 0.2 0.35 11.0 0.1 2.0 2 0 0 2 2 2 0 Cnl2/NKP2 family protein CENP-H PF05837.12 ORX42603.1 - 0.65 10.4 4.4 0.88 10.0 2.3 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Hrs_helical PF12210.8 ORX42603.1 - 1.9 9.1 5.1 3.8 8.1 2.2 2.5 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate zf-C2H2_2 PF12756.7 ORX42675.1 - 0.062 13.6 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX42675.1 - 1.3 10.1 3.0 7.7 7.6 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Aldo_ket_red PF00248.21 ORX42679.1 - 1.2e-66 225.0 0.0 1.3e-66 224.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_8 PF02954.19 ORX42679.1 - 0.19 11.5 0.2 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Aa_trans PF01490.18 ORX42680.1 - 7.3e-59 199.5 20.1 1.2e-58 198.8 20.1 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein UQ_con PF00179.26 ORX42681.1 - 2.6e-48 163.2 0.0 3.5e-48 162.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX42681.1 - 0.00069 19.9 0.0 0.0012 19.1 0.1 1.4 1 1 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 ORX42681.1 - 0.0014 18.4 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ORX42681.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 UEV domain Bromodomain PF00439.25 ORX42682.1 - 2.6e-97 319.0 7.5 4e-23 81.3 0.1 5.7 5 0 0 5 5 5 5 Bromodomain Peptidase_M1 PF01433.20 ORX42682.1 - 0.001 18.7 0.9 0.0016 18.1 0.2 1.6 2 0 0 2 2 2 1 Peptidase family M1 domain HEAT_2 PF13646.6 ORX42682.1 - 0.018 15.4 0.1 0.15 12.5 0.1 2.5 3 0 0 3 3 3 0 HEAT repeats ASH PF15780.5 ORX42684.1 - 6.2e-14 52.0 0.8 0.00064 19.9 0.0 9.4 10 1 0 10 10 10 2 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 ORX42684.1 - 9.7e-06 25.7 0.1 4.7 7.4 0.0 4.9 5 0 0 5 5 5 3 Flagellar-associated PapD-like DUF1573 PF07610.11 ORX42684.1 - 5.8e-05 23.1 0.3 35 4.5 0.0 7.4 8 2 0 8 8 8 0 Protein of unknown function (DUF1573) fn3_5 PF06280.12 ORX42684.1 - 0.00022 21.9 1.9 2.9 8.6 0.0 7.2 9 0 0 9 9 9 1 Fn3-like domain Transglut_C PF00927.22 ORX42684.1 - 0.023 14.9 0.0 5.1 7.3 0.0 4.6 5 0 0 5 5 5 0 Transglutaminase family, C-terminal ig like domain DUF5001 PF16392.5 ORX42684.1 - 0.024 14.6 0.0 29 4.6 0.0 4.4 4 0 0 4 4 4 0 Ig-like domain DUF1090 PF06476.12 ORX42684.1 - 0.56 10.4 8.9 1.1 9.4 8.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) DUF5405 PF17399.2 ORX42685.1 - 0.17 12.1 0.1 0.23 11.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5405) zf-CCHC PF00098.23 ORX42718.1 - 2.3e-06 27.4 13.7 0.00088 19.2 2.6 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 ORX42718.1 - 0.024 14.4 5.0 0.34 10.7 0.1 2.7 2 0 0 2 2 2 0 Zinc knuckle Pga1 PF10333.9 ORX42722.1 - 0.055 13.3 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 GPI-Mannosyltransferase II co-activator Exo_endo_phos PF03372.23 ORX42724.1 - 0.099 12.1 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family PIN_4 PF13638.6 ORX42725.1 - 4.3e-26 91.7 0.1 6.5e-26 91.2 0.1 1.3 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 ORX42725.1 - 0.015 15.6 0.1 0.04 14.2 0.1 1.8 1 1 0 1 1 1 0 PIN like domain MS_channel PF00924.18 ORX42726.1 - 6e-15 55.3 0.2 1.3e-14 54.2 0.2 1.6 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_6 PF13405.6 ORX42726.1 - 0.00087 19.0 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_1 PF00036.32 ORX42726.1 - 0.0015 17.9 0.0 0.003 17.0 0.0 1.5 1 0 0 1 1 1 1 EF hand Cytokin_check_N PF10407.9 ORX42726.1 - 0.01 15.8 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus EF-hand_5 PF13202.6 ORX42726.1 - 0.011 15.3 0.1 0.023 14.2 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 ORX42726.1 - 0.021 15.2 0.1 0.053 14.0 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair NDUFB11 PF17250.2 ORX42726.1 - 0.033 14.8 0.0 0.12 13.0 0.0 1.9 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit DUF3382 PF11862.8 ORX42726.1 - 0.12 12.6 0.1 0.12 12.6 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3382) CzcE PF16986.5 ORX42726.1 - 0.13 12.6 0.0 0.38 11.1 0.0 1.8 1 0 0 1 1 1 0 Heavy-metal resistance protein CzcE SipA_VBS PF17985.1 ORX42726.1 - 0.5 10.4 3.0 1.2 9.2 3.0 1.6 1 0 0 1 1 1 0 SipA vinculin binding site GPP34 PF05719.11 ORX42728.1 - 1.1e-61 208.5 0.0 1.4e-61 208.1 0.0 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) YqfD PF06898.11 ORX42729.1 - 0.011 14.6 5.3 0.01 14.7 5.3 1.1 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD DUF3692 PF12469.8 ORX42729.1 - 0.041 14.1 0.7 0.057 13.6 0.7 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Presenilin PF01080.17 ORX42729.1 - 9.4 4.9 7.9 8.9 5.0 7.9 1.0 1 0 0 1 1 1 0 Presenilin RNase_T PF00929.24 ORX42730.1 - 1.2e-21 78.0 0.8 1.4e-20 74.4 0.8 2.0 1 1 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ORX42730.1 - 0.0003 20.8 0.3 0.00037 20.5 0.3 1.1 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like ERG2_Sigma1R PF04622.12 ORX42731.1 - 1.3e-84 282.8 0.1 1.4e-84 282.6 0.1 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein OrfB_Zn_ribbon PF07282.11 ORX42732.1 - 0.015 15.2 0.4 0.044 13.7 0.4 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain ORF6C PF10552.9 ORX42733.1 - 0.032 14.3 1.9 4.4 7.4 0.2 2.2 2 0 0 2 2 2 0 ORF6C domain CryBP1 PF07029.11 ORX42733.1 - 0.034 14.3 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 CryBP1 protein Psb28 PF03912.14 ORX42733.1 - 0.058 13.7 0.2 0.13 12.6 0.2 1.5 1 0 0 1 1 1 0 Psb28 protein CK2S PF15011.6 ORX42777.1 - 0.0068 16.3 0.2 1.6 8.6 0.0 2.5 2 0 0 2 2 2 2 Casein Kinase 2 substrate HTH_32 PF13565.6 ORX42778.1 - 7.8e-06 26.4 0.0 1.8e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ORX42778.1 - 0.00018 21.6 0.0 0.00031 20.8 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ORX42778.1 - 0.00037 20.5 0.0 0.00085 19.3 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 ORX42778.1 - 0.00099 18.8 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX42778.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Mso1_Sec1_bdg PF14475.6 ORX42779.1 - 0.0046 16.5 0.2 0.011 15.3 0.2 1.7 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Phage_GP20 PF06810.11 ORX42779.1 - 0.51 10.1 9.0 0.09 12.6 2.8 2.2 2 0 0 2 2 2 0 Phage minor structural protein GP20 Pho88 PF10032.9 ORX42780.1 - 3.2e-50 169.9 0.2 3.6e-50 169.7 0.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) Arrestin_C PF02752.22 ORX42781.1 - 4.5e-08 33.6 3.3 0.0028 18.1 0.0 2.8 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX42781.1 - 1.3e-05 25.3 0.0 4e-05 23.7 0.0 1.7 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF4476 PF14771.6 ORX42781.1 - 0.061 13.6 0.1 0.12 12.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Macoilin PF09726.9 ORX42781.1 - 2.1 6.8 6.4 3.2 6.2 6.4 1.2 1 0 0 1 1 1 0 Macoilin family DUF5082 PF16888.5 ORX42782.1 - 0.019 15.2 0.4 0.056 13.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Nitrophorin PF02087.15 ORX42782.1 - 0.025 14.6 0.0 0.037 14.0 0.0 1.2 1 0 0 1 1 1 0 Nitrophorin WD40 PF00400.32 ORX42784.1 - 3.9e-28 97.1 17.2 5.1e-07 30.3 0.3 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX42784.1 - 4.1e-25 87.9 2.9 1.8e-05 24.9 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX42784.1 - 3.9e-08 33.4 0.9 0.00065 19.6 0.3 3.7 1 1 4 5 5 5 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX42784.1 - 1.3e-06 27.3 0.9 0.0015 17.2 0.2 2.3 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ORX42784.1 - 1.5e-05 24.2 0.1 2.5e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Coatomer WD associated region IKI3 PF04762.12 ORX42784.1 - 0.00028 19.1 0.0 0.16 9.9 0.0 2.2 1 1 1 2 2 2 2 IKI3 family WD40_like PF17005.5 ORX42784.1 - 0.0008 18.8 0.1 1.5 8.1 0.1 2.9 2 1 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ORX42784.1 - 0.0011 18.9 0.1 0.016 15.1 0.0 3.0 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ORX42784.1 - 0.002 16.7 0.1 0.027 13.0 0.1 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain RAB3GAP2_N PF14655.6 ORX42784.1 - 0.11 11.8 0.0 3.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus SdiA-regulated PF06977.11 ORX42784.1 - 0.18 11.0 0.0 0.44 9.7 0.0 1.6 1 0 0 1 1 1 0 SdiA-regulated zf-C2H2_2 PF12756.7 ORX42785.1 - 0.0037 17.6 1.6 0.0095 16.2 1.6 1.7 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ORX42785.1 - 0.066 13.9 1.1 0.25 12.0 0.2 2.3 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 ORX42785.1 - 0.088 13.7 7.9 1.2 10.2 1.8 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger Dynamin_M PF01031.20 ORX42786.1 - 4.6e-109 364.0 0.0 5.2e-108 360.6 0.0 2.2 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ORX42786.1 - 1.8e-55 187.6 0.0 3.8e-55 186.5 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ORX42786.1 - 8.7e-32 109.1 2.9 2.3e-31 107.8 2.9 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ORX42786.1 - 6.3e-05 23.0 0.0 0.00023 21.2 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX42786.1 - 0.011 16.2 0.1 0.059 13.7 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain AAA_28 PF13521.6 ORX42786.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ORX42786.1 - 0.16 12.2 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF4491 PF14898.6 ORX42787.1 - 0.13 12.7 0.0 0.14 12.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) NOB1_Zn_bind PF08772.11 ORX42788.1 - 1e-30 105.7 1.5 2.4e-30 104.5 1.5 1.7 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 ORX42788.1 - 2.4e-28 98.4 0.0 4.9e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease CAF20 PF17052.5 ORX42788.1 - 0.022 14.9 2.6 0.078 13.1 2.6 1.9 1 1 0 1 1 1 0 Cap associated factor DZR PF12773.7 ORX42788.1 - 0.054 13.5 0.6 0.11 12.5 0.6 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-NADH-PPase PF09297.11 ORX42788.1 - 0.25 11.0 3.4 0.37 10.5 0.6 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Rad1 PF02144.16 ORX42789.1 - 1e-41 142.8 0.0 2.4e-41 141.6 0.0 1.5 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 AlaDh_PNT_N PF05222.15 ORX42790.1 - 2.3e-27 95.9 0.0 3.3e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 ORX42790.1 - 4.7e-05 22.8 0.0 0.00044 19.6 0.0 2.1 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain WD40 PF00400.32 ORX42791.1 - 6.8e-25 86.9 6.7 4.6e-05 24.1 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 ORX42791.1 - 1.4e-22 79.8 2.4 5.2e-22 77.9 1.6 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 ORX42791.1 - 1.1e-08 35.2 0.6 0.00083 19.6 0.2 4.4 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX42791.1 - 4.3e-05 23.5 0.5 0.44 10.4 0.0 3.3 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX42791.1 - 0.0017 17.4 0.1 2.7 6.9 0.0 3.5 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ORX42791.1 - 0.072 11.1 0.1 0.14 10.1 0.1 1.4 1 1 0 1 1 1 0 IKI3 family Ecl1 PF12855.7 ORX42792.1 - 3.9e-12 47.7 10.1 5.1e-12 47.3 10.1 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 ORX42792.1 - 0.0003 20.8 2.6 0.00048 20.2 2.6 1.3 1 0 0 1 1 1 1 MYND finger zf-C6H2 PF15801.5 ORX42792.1 - 0.049 13.9 0.7 0.083 13.2 0.7 1.3 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding ANF_receptor PF01094.28 ORX42794.1 - 2.9e-37 128.6 4.8 4.7e-37 127.9 4.8 1.4 1 1 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 ORX42794.1 - 1.2e-17 64.6 4.8 1.7e-17 64.1 4.8 1.2 1 0 0 1 1 1 1 Periplasmic binding protein DIL PF01843.19 ORX42795.1 - 2.4e-27 95.2 2.4 6.2e-27 93.9 2.4 1.8 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 ORX42795.1 - 0.0002 21.8 0.2 0.0041 17.7 0.0 2.6 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX42795.1 - 0.046 14.2 0.0 0.29 11.7 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ORX42795.1 - 0.15 12.7 0.1 5.2 8.0 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat SUR7 PF06687.12 ORX42796.1 - 4.1e-13 49.4 10.6 4.1e-13 49.4 10.6 1.7 1 1 1 2 2 2 1 SUR7/PalI family Rax2 PF12768.7 ORX42796.1 - 0.53 9.7 1.6 3.9 6.9 1.6 2.1 1 1 0 1 1 1 0 Cortical protein marker for cell polarity SLATT_1 PF18181.1 ORX42796.1 - 0.67 9.9 2.1 0.72 9.8 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 EphA2_TM PF14575.6 ORX42796.1 - 7.5 7.5 0.0 7.5 7.5 0.0 3.6 4 0 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Ribosomal_L10 PF00466.20 ORX42797.1 - 1.5e-24 86.0 0.8 2.4e-23 82.2 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 ORX42797.1 - 1.4e-22 79.5 0.1 2.6e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 ORX42797.1 - 8.6e-14 51.9 6.8 1.8e-13 50.9 5.1 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein KorB_C PF06613.11 ORX42797.1 - 0.05 13.6 0.0 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 KorB C-terminal beta-barrel domain Ribosomal_L14e PF01929.17 ORX42798.1 - 4.6e-29 100.7 2.5 6.5e-29 100.2 2.5 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ORX42798.1 - 0.11 12.5 0.1 0.36 10.8 0.1 1.9 2 0 0 2 2 2 0 KOW motif EST1_DNA_bind PF10373.9 ORX42799.1 - 6.1e-20 71.8 0.3 1e-19 71.1 0.3 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain PIN_4 PF13638.6 ORX42799.1 - 9.4e-11 42.1 5.2 5.7e-06 26.7 0.3 3.3 2 1 0 3 3 3 2 PIN domain EST1 PF10374.9 ORX42799.1 - 9.9e-10 39.2 1.1 9.9e-10 39.2 1.1 2.7 2 1 0 2 2 2 1 Telomerase activating protein Est1 PAP_central PF04928.17 ORX42799.1 - 0.077 12.0 0.2 0.16 10.9 0.2 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain REV PF00424.18 ORX42799.1 - 0.083 12.9 2.9 0.5 10.4 2.9 2.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) Nop14 PF04147.12 ORX42799.1 - 0.25 9.5 15.7 0.4 8.9 15.7 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ORX42799.1 - 1.5 8.1 22.0 3.2 7.0 22.0 1.5 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ORX42799.1 - 1.5 8.1 18.7 2.6 7.4 18.7 1.3 1 0 0 1 1 1 0 SDA1 HAUS6_N PF14661.6 ORX42800.1 - 5e-15 55.7 3.7 1.9e-13 50.5 3.7 2.3 1 1 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus DUF2193 PF09959.9 ORX42800.1 - 0.12 10.8 0.1 0.17 10.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) OrfB_Zn_ribbon PF07282.11 ORX42801.1 - 1.5e-05 24.8 4.0 1.5e-05 24.8 4.0 2.9 2 1 0 2 2 2 1 Putative transposase DNA-binding domain MLVIN_C PF18697.1 ORX42884.1 - 0.00071 19.6 0.6 0.0021 18.1 0.1 2.0 1 1 1 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain HEPN_Swt1 PF18731.1 ORX42884.1 - 0.0082 16.5 0.1 0.012 16.0 0.1 1.2 1 0 0 1 1 1 1 Swt1-like HEPN Rot1 PF10681.9 ORX42884.1 - 0.098 12.2 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal EcKinase PF02958.20 ORX42885.1 - 0.2 11.0 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase MATalpha_HMGbox PF04769.12 ORX42887.1 - 0.029 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box FdsD PF11390.8 ORX42888.1 - 7.5 7.0 8.7 17 5.8 0.4 2.7 3 0 0 3 3 3 0 NADH-dependant formate dehydrogenase delta subunit FdsD Carn_acyltransf PF00755.20 ORX42889.1 - 2.1e-195 650.8 0.0 2.4e-195 650.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase TraF PF13728.6 ORX42890.1 - 3.9 7.2 7.8 7.2 6.4 7.8 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Acid_PPase PF12689.7 ORX42892.1 - 6.5e-51 172.5 0.1 7.8e-51 172.3 0.1 1.1 1 0 0 1 1 1 1 Acid Phosphatase NIF PF03031.18 ORX42892.1 - 0.019 14.8 0.0 0.025 14.4 0.0 1.2 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase Recep_L_domain PF01030.24 ORX42893.1 - 6.8e-10 39.1 5.9 0.023 14.8 0.9 4.8 1 1 1 3 3 3 3 Receptor L domain LRR_4 PF12799.7 ORX42893.1 - 5.9e-05 23.4 8.1 1.5 9.4 0.0 6.3 2 1 3 5 5 5 1 Leucine Rich repeats (2 copies) LRR_5 PF13306.6 ORX42893.1 - 0.0076 16.2 0.2 0.16 11.9 0.1 2.3 1 1 2 3 3 3 2 BspA type Leucine rich repeat region (6 copies) LRR_9 PF14580.6 ORX42893.1 - 0.013 15.0 1.6 0.18 11.3 0.1 3.0 1 1 2 3 3 3 0 Leucine-rich repeat MFS_1 PF07690.16 ORX42894.1 - 8.7e-35 120.3 78.9 1.2e-28 100.1 46.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily F-box-like PF12937.7 ORX42895.1 - 0.00044 20.1 0.5 0.0011 18.8 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX42895.1 - 0.0039 17.0 0.1 0.013 15.3 0.1 1.9 1 0 0 1 1 1 1 F-box domain F-box PF00646.33 ORX42896.1 - 8.2e-05 22.4 0.9 0.00017 21.3 0.9 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX42896.1 - 0.00056 19.8 2.4 0.00056 19.8 2.4 1.8 2 1 0 2 2 2 1 F-box-like F-box_4 PF15966.5 ORX42896.1 - 0.03 14.2 0.2 0.044 13.7 0.2 1.3 1 0 0 1 1 1 0 F-box DEDD_Tnp_IS110 PF01548.17 ORX42898.1 - 0.064 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Transposase Cornichon PF03311.14 ORX42900.1 - 4.8e-51 172.2 16.5 5.5e-51 172.0 16.5 1.0 1 0 0 1 1 1 1 Cornichon protein Cullin PF00888.22 ORX42901.1 - 2e-148 495.8 8.8 2.8e-148 495.3 8.8 1.2 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX42901.1 - 3.8e-25 87.7 8.1 1.5e-24 85.8 5.3 3.2 3 0 0 3 3 3 1 Cullin protein neddylation domain TrmB PF01978.19 ORX42901.1 - 0.0031 17.4 0.1 0.21 11.5 0.0 2.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_IclR PF09339.10 ORX42901.1 - 0.0093 15.7 0.1 0.023 14.5 0.1 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain Rrf2 PF02082.20 ORX42901.1 - 0.041 14.2 0.1 0.11 12.9 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_5 PF01022.20 ORX42901.1 - 0.11 12.4 0.2 0.24 11.3 0.2 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family SMC_N PF02463.19 ORX42902.1 - 3.4e-65 219.6 0.0 7.1e-65 218.5 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX42902.1 - 2.4e-27 95.6 0.0 9.3e-27 93.7 0.0 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX42902.1 - 2.5e-13 50.5 5.4 1.6e-06 28.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX42902.1 - 4.2e-07 29.6 0.0 8.7e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ORX42902.1 - 6e-07 29.5 24.5 6e-07 29.5 24.5 4.6 2 2 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 ORX42902.1 - 0.0059 16.8 0.1 0.019 15.2 0.1 1.9 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 ORX42902.1 - 0.09 13.3 0.0 0.09 13.3 0.0 6.4 4 3 0 5 5 5 0 ABC transporter AAA_23 PF13476.6 ORX42902.1 - 0.15 12.5 118.0 18 5.7 0.8 7.1 3 2 0 3 3 3 0 AAA domain Methyltr_RsmB-F PF01189.17 ORX42903.1 - 2.3e-39 135.1 0.0 1.9e-38 132.1 0.0 2.3 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 ORX42903.1 - 0.02 15.0 0.0 0.044 13.9 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase zf-met PF12874.7 ORX42918.1 - 0.052 14.0 0.3 0.11 13.0 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ORX42918.1 - 0.2 12.6 0.6 0.71 10.9 0.6 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger RRM_1 PF00076.22 ORX42919.1 - 5.3e-23 80.6 0.5 6.9e-12 45.0 0.0 3.6 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX42919.1 - 6.5e-07 29.4 0.1 0.00025 21.1 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 ORX42919.1 - 0.004 17.0 0.0 0.22 11.3 0.0 2.8 2 1 1 3 3 3 1 Rrp7 RRM-like N-terminal domain SET_assoc PF11767.8 ORX42919.1 - 0.012 15.2 0.0 0.055 13.1 0.0 2.1 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated CO_dh PF02552.16 ORX42919.1 - 0.022 14.6 0.2 0.045 13.5 0.2 1.5 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit CPSF100_C PF13299.6 ORX42919.1 - 0.21 11.8 8.4 0.36 11.0 1.8 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF5327 PF17261.2 ORX42919.1 - 1.1 10.1 8.6 0.27 12.0 1.2 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5327) DUF2477 PF10631.9 ORX42919.1 - 2.8 8.6 6.7 1.9 9.2 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2477) Neur_chan_memb PF02932.16 ORX42919.1 - 4.4 7.3 7.2 9 6.3 0.4 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CBS PF00571.28 ORX42920.1 - 1.4e-20 73.4 2.1 5.8e-09 36.3 0.0 3.5 3 0 0 3 3 3 3 CBS domain DUF1803 PF08820.10 ORX42920.1 - 0.071 13.2 0.2 6.2 6.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) Mo25 PF08569.11 ORX42921.1 - 1.6e-136 455.0 18.8 1.8e-136 454.8 18.8 1.0 1 0 0 1 1 1 1 Mo25-like Lipocalin_7 PF14651.6 ORX42921.1 - 0.071 13.0 0.3 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family GYF PF02213.16 ORX42922.1 - 1.2e-18 66.4 1.1 3.1e-18 65.2 1.1 1.7 1 0 0 1 1 1 1 GYF domain GYF_2 PF14237.6 ORX42922.1 - 4.1e-06 26.5 0.3 1.7e-05 24.5 0.3 2.2 1 0 0 1 1 1 1 GYF domain 2 AAA_23 PF13476.6 ORX42922.1 - 0.0096 16.4 5.5 0.0096 16.4 5.5 3.5 3 1 0 3 3 3 1 AAA domain PS_Dcarbxylase PF02666.15 ORX42923.1 - 1.1e-58 198.1 0.0 6e-58 195.7 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase C2 PF00168.30 ORX42923.1 - 7e-34 116.2 0.0 2.1e-19 69.7 0.1 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_7 PF13499.6 ORX42923.1 - 0.0019 18.6 0.1 0.0082 16.6 0.1 2.1 1 0 0 1 1 1 1 EF-hand domain pair CEP76-C2 PF15627.6 ORX42923.1 - 0.0019 17.8 0.1 0.52 9.9 0.0 2.4 2 0 0 2 2 2 2 CEP76 C2 domain EF-hand_6 PF13405.6 ORX42923.1 - 0.19 11.7 0.9 0.83 9.8 0.0 2.5 3 0 0 3 3 3 0 EF-hand domain Pkinase PF00069.25 ORX42924.1 - 3.8e-17 62.5 0.0 7.2e-17 61.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX42924.1 - 1.4e-16 60.6 0.0 2.6e-16 59.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ORX42924.1 - 0.018 14.6 1.5 0.033 13.8 0.0 2.1 3 0 0 3 3 3 0 Choline/ethanolamine kinase APH PF01636.23 ORX42924.1 - 0.057 13.3 1.9 0.084 12.8 0.1 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 ORX42925.1 - 2.9e-19 69.0 16.6 0.00041 21.1 0.7 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX42925.1 - 3.8e-08 33.5 0.5 0.66 10.3 0.0 4.2 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Myb_DNA-binding PF00249.31 ORX42925.1 - 9.7e-06 25.7 0.0 2.9e-05 24.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain PPR_2 PF13041.6 ORX42926.1 - 7.1e-10 38.9 0.5 5.7e-05 23.2 0.0 4.1 2 1 2 4 4 4 2 PPR repeat family PPR_3 PF13812.6 ORX42926.1 - 0.015 15.3 0.1 6.3 7.0 0.0 3.2 3 0 0 3 3 3 0 Pentatricopeptide repeat domain Arena_ncap_C PF17290.2 ORX42926.1 - 0.037 13.4 0.0 0.067 12.5 0.0 1.3 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain p450 PF00067.22 ORX42927.1 - 1.9e-80 270.9 4.1 2.4e-80 270.6 4.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF2914 PF11141.8 ORX42928.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) MKT1_C PF12246.8 ORX42929.1 - 9.2e-33 113.5 0.8 9.9e-33 113.4 0.8 1.0 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication RhoGEF PF00621.20 ORX42930.1 - 2.8e-35 122.2 4.2 6.3e-35 121.1 4.2 1.6 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.11 ORX42930.1 - 8.8e-25 86.8 0.0 1.6e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 CDC24 Calponin PH_10 PF15411.6 ORX42930.1 - 1.9e-18 66.9 0.1 3.6e-18 66.0 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 ORX42930.1 - 1.4e-14 53.7 0.0 4.6e-14 52.1 0.0 1.9 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 ORX42930.1 - 0.027 15.0 0.2 0.071 13.6 0.2 1.7 1 0 0 1 1 1 0 PH domain PH_5 PF15405.6 ORX42930.1 - 0.081 13.0 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain XRCC1_N PF01834.16 ORX42930.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.3 1 0 0 1 1 1 0 XRCC1 N terminal domain Phage_lysozyme PF00959.19 ORX42930.1 - 0.15 12.5 0.0 0.41 11.1 0.0 1.7 1 0 0 1 1 1 0 Phage lysozyme Voltage_CLC PF00654.20 ORX42931.1 - 0.042 13.1 0.2 0.05 12.8 0.2 1.1 1 0 0 1 1 1 0 Voltage gated chloride channel JCAD PF15351.6 ORX42932.1 - 6.7 4.3 6.5 7.9 4.1 6.5 1.0 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease Pox_MCEL PF03291.16 ORX42933.1 - 1.1e-82 277.9 0.0 2e-82 277.0 0.0 1.3 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 ORX42933.1 - 6.2e-12 46.1 0.1 1.9e-11 44.5 0.1 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX42933.1 - 5.1e-06 27.1 0.0 1.3e-05 25.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX42933.1 - 1.6e-05 25.4 0.0 3.2e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX42933.1 - 0.0001 22.1 0.0 0.00091 19.1 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ORX42933.1 - 0.028 13.6 0.0 0.045 12.9 0.0 1.3 1 1 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_23 PF13489.6 ORX42933.1 - 0.054 13.3 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ORX42933.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Pkinase PF00069.25 ORX42934.1 - 4.6e-62 209.8 0.0 5.8e-62 209.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX42934.1 - 6.4e-38 130.5 0.0 8.4e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX42934.1 - 1.8e-07 30.3 0.0 2.7e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX42934.1 - 0.00081 18.8 0.0 0.0013 18.1 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX42934.1 - 0.0025 17.2 0.0 0.0053 16.1 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX42934.1 - 0.026 13.5 0.1 0.082 11.8 0.1 1.7 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX42934.1 - 0.043 13.7 0.0 0.54 10.1 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ORX42934.1 - 0.078 12.0 0.1 0.12 11.4 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 HSF_DNA-bind PF00447.17 ORX42935.1 - 4.5e-33 113.7 4.5 9.1e-33 112.8 4.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding AKNA PF12443.8 ORX42935.1 - 0.03 15.0 0.1 0.1 13.3 0.1 2.0 1 0 0 1 1 1 0 AT-hook-containing transcription factor AP_endonuc_2_N PF07582.12 ORX42935.1 - 0.1 12.3 0.1 2.8 7.7 0.0 2.4 2 0 0 2 2 2 0 AP endonuclease family 2 C terminus SlyX PF04102.12 ORX42935.1 - 0.13 12.9 1.3 0.24 12.0 1.3 1.5 1 0 0 1 1 1 0 SlyX ZapB PF06005.12 ORX42935.1 - 0.54 10.7 1.5 0.55 10.7 0.2 1.7 2 0 0 2 2 2 0 Cell division protein ZapB DUF2781 PF10914.8 ORX42936.1 - 2.8e-38 131.6 14.6 4.2e-38 131.1 14.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Prefoldin PF02996.17 ORX42936.1 - 1e-08 35.1 0.0 1.6e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Prefoldin subunit CSD PF00313.22 ORX42937.1 - 2.2e-20 72.3 0.2 3.5e-20 71.6 0.2 1.4 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 ORX42937.1 - 0.0069 16.0 0.1 0.014 15.1 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease B OB domain HABP4_PAI-RBP1 PF04774.15 ORX42938.1 - 0.00035 21.4 11.6 0.00035 21.4 11.6 3.4 1 1 2 3 3 3 1 Hyaluronan / mRNA binding family Stm1_N PF09598.10 ORX42938.1 - 0.044 14.6 6.3 0.044 14.6 6.3 3.2 3 1 0 3 3 3 0 Stm1 PH PF00169.29 ORX42939.1 - 1.1e-12 48.4 0.2 0.0094 16.5 0.0 4.7 3 2 0 3 3 3 3 PH domain PH_4 PF15404.6 ORX42939.1 - 1.7e-05 24.7 6.4 0.002 18.0 0.1 3.6 3 0 0 3 3 3 2 Pleckstrin homology domain PH_9 PF15410.6 ORX42939.1 - 0.027 14.9 3.5 0.33 11.3 0.0 3.6 4 0 0 4 4 4 0 Pleckstrin homology domain Presenilin PF01080.17 ORX42939.1 - 0.13 11.0 1.7 0.21 10.3 1.7 1.2 1 0 0 1 1 1 0 Presenilin SAGA-Tad1 PF12767.7 ORX43008.1 - 1.2e-49 169.1 0.0 1.7e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit Dfp1_Him1_M PF08630.10 ORX43009.1 - 1.6e-16 60.6 1.1 2.6e-16 60.0 0.1 1.8 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 ORX43009.1 - 1.4e-13 50.7 1.6 2.6e-13 49.8 1.6 1.5 1 0 0 1 1 1 1 DBF zinc finger Vps39_2 PF10367.9 ORX43009.1 - 0.14 12.6 2.1 0.27 11.7 2.1 1.4 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Creatinase_N_2 PF16189.5 ORX43011.1 - 1e-46 159.0 0.0 4.5e-46 156.9 0.0 1.9 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ORX43011.1 - 3.3e-41 141.3 0.1 5.4e-41 140.6 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 ORX43011.1 - 1.1e-22 81.1 0.0 5.3e-17 62.7 0.0 2.5 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Peptidase_M24_C PF16188.5 ORX43011.1 - 6.8e-21 74.1 0.1 5.7e-20 71.1 0.0 2.6 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Pkinase PF00069.25 ORX43012.1 - 1.3e-62 211.5 0.1 1.6e-62 211.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX43012.1 - 2.1e-21 76.4 0.0 3.2e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX43012.1 - 3.7e-06 27.0 0.3 4.1e-05 23.6 0.6 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX43012.1 - 0.0022 17.4 0.2 0.0039 16.6 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX43012.1 - 0.0035 16.2 0.1 0.012 14.4 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ORX43012.1 - 0.019 14.5 0.2 0.03 13.9 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase OrfB_Zn_ribbon PF07282.11 ORX43013.1 - 7.6e-08 32.2 0.1 1.1e-07 31.7 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain UQ_con PF00179.26 ORX43014.1 - 1.5e-38 131.6 0.0 1.9e-38 131.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX43014.1 - 0.00037 20.2 0.0 0.00061 19.5 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ORX43014.1 - 0.0064 16.8 0.0 0.016 15.5 0.0 1.6 2 0 0 2 2 2 1 RWD domain ECH_1 PF00378.20 ORX43015.1 - 3.1e-35 121.7 0.0 3.9e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX43015.1 - 1.3e-13 51.2 0.0 5.7e-12 45.8 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Mg_trans_NIPA PF05653.14 ORX43017.1 - 1.1e-58 198.7 11.0 1.3e-58 198.5 11.0 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX43017.1 - 0.00013 22.2 2.4 0.00013 22.2 2.4 3.7 2 1 1 3 3 3 1 EamA-like transporter family GPR_Gpa2_C PF11970.8 ORX43017.1 - 0.16 12.1 3.8 0.61 10.2 3.9 1.9 1 1 1 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Claudin_3 PF06653.11 ORX43017.1 - 0.71 9.8 8.4 1.4 8.9 8.4 1.6 1 1 0 1 1 1 0 Tight junction protein, Claudin-like DUF4407 PF14362.6 ORX43018.1 - 0.19 11.0 3.7 0.24 10.7 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 ORX43018.1 - 0.24 11.9 4.6 0.41 11.1 3.0 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 ORX43018.1 - 0.32 11.1 3.1 14 5.7 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ORX43018.1 - 2.6 8.2 5.9 3.9 7.7 1.7 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family UPF0176_N PF17773.1 ORX43019.1 - 1.9e-17 63.4 0.0 4e-17 62.3 0.0 1.6 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese_C PF12368.8 ORX43019.1 - 1.6e-15 57.2 10.5 1.6e-15 57.2 10.5 2.1 2 0 0 2 2 2 1 Rhodanase C-terminal Rhodanese PF00581.20 ORX43019.1 - 1.3e-06 28.8 0.0 3e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain S10_plectin PF03501.15 ORX43020.1 - 8.2e-45 150.8 0.1 9.9e-45 150.5 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 ORX43020.1 - 0.054 13.3 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TrmB PF01978.19 ORX43020.1 - 0.067 13.1 0.0 0.14 12.0 0.0 1.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB MFS_1_like PF12832.7 ORX43021.1 - 1.2e-05 24.4 28.8 4.8e-05 22.4 28.8 1.9 1 1 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ORX43021.1 - 0.0021 17.0 8.5 0.0021 17.0 8.5 2.8 3 0 0 3 3 3 2 Major Facilitator Superfamily Abhydrolase_3 PF07859.13 ORX43022.1 - 1.2e-56 192.0 0.0 1.5e-56 191.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX43022.1 - 2.3e-08 33.3 0.1 3e-08 32.9 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 ORX43022.1 - 6e-08 32.0 1.4 3.2e-07 29.6 1.4 1.8 1 1 0 1 1 1 1 Carboxylesterase family AXE1 PF05448.12 ORX43022.1 - 0.0013 17.4 0.0 0.32 9.6 0.0 2.2 2 0 0 2 2 2 2 Acetyl xylan esterase (AXE1) Chlorophyllase2 PF12740.7 ORX43022.1 - 0.0032 16.4 0.0 0.0049 15.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.21 ORX43022.1 - 0.071 12.6 0.1 0.38 10.2 0.1 2.1 1 1 0 1 1 1 0 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ORX43022.1 - 0.14 11.4 0.0 0.53 9.5 0.0 1.9 1 1 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX43022.1 - 0.36 11.4 1.7 3.4 8.2 1.7 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ORX43023.1 - 4.5e-55 186.8 0.1 5.8e-55 186.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ORX43023.1 - 1.6e-10 40.5 0.0 5.8e-10 38.6 0.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Chlorophyllase2 PF12740.7 ORX43023.1 - 7.8e-06 25.0 0.0 1.3e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Chlorophyllase enzyme Say1_Mug180 PF10340.9 ORX43023.1 - 0.0016 17.4 0.0 0.0025 16.8 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX43023.1 - 0.0046 16.4 0.0 0.064 12.7 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ORX43023.1 - 0.028 14.0 0.0 0.32 10.5 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 ORX43025.1 - 3.3e-61 206.8 0.1 4.1e-61 206.5 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ORX43025.1 - 2.2e-08 33.5 1.0 7.6e-08 31.7 1.0 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ORX43025.1 - 4.6e-07 29.5 0.0 1.1e-06 28.3 0.0 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase family Say1_Mug180 PF10340.9 ORX43025.1 - 0.0025 16.7 0.0 0.0038 16.1 0.0 1.3 1 0 0 1 1 1 1 Steryl acetyl hydrolase DLH PF01738.18 ORX43025.1 - 0.003 17.2 0.0 0.11 12.0 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ORX43025.1 - 0.0094 15.2 0.0 0.92 8.7 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 ORX43025.1 - 0.014 14.3 0.0 0.024 13.6 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme TPR_2 PF07719.17 ORX43026.1 - 4e-50 163.9 45.9 1.2e-06 28.2 0.0 18.9 18 1 0 18 18 18 11 Tetratricopeptide repeat TPR_1 PF00515.28 ORX43026.1 - 1.6e-40 135.3 42.4 1.8e-06 27.5 0.0 17.4 20 0 0 20 20 20 8 Tetratricopeptide repeat TPR_16 PF13432.6 ORX43026.1 - 1.6e-34 118.2 19.2 1.4e-08 35.3 0.0 9.2 7 2 1 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ORX43026.1 - 5.6e-31 104.2 35.7 4.9e-05 23.2 0.3 16.0 18 1 0 18 18 15 8 Tetratricopeptide repeat TPR_12 PF13424.6 ORX43026.1 - 2.1e-26 92.0 34.9 2.9e-07 30.7 0.1 11.6 7 4 5 12 12 12 7 Tetratricopeptide repeat TPR_7 PF13176.6 ORX43026.1 - 8.2e-26 88.1 31.3 0.00051 19.9 0.0 14.1 16 0 0 16 16 15 7 Tetratricopeptide repeat TPR_9 PF13371.6 ORX43026.1 - 1.4e-23 82.9 15.1 0.00013 22.0 0.0 9.4 8 2 2 10 10 9 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX43026.1 - 6.7e-23 79.4 33.3 0.0088 16.8 0.0 16.4 15 3 2 17 17 17 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX43026.1 - 8.2e-21 73.4 26.5 0.00055 19.6 0.0 12.6 11 2 2 13 13 13 5 TPR repeat TPR_17 PF13431.6 ORX43026.1 - 9.1e-21 72.7 28.6 0.18 12.2 0.1 14.5 15 0 0 15 15 14 5 Tetratricopeptide repeat TPR_19 PF14559.6 ORX43026.1 - 1.1e-20 73.9 24.9 0.0029 18.1 0.1 12.6 9 4 4 14 14 13 6 Tetratricopeptide repeat TPR_6 PF13174.6 ORX43026.1 - 7.5e-09 35.7 26.9 3.5 8.5 0.0 13.3 14 0 0 14 14 13 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX43026.1 - 6e-07 29.1 29.9 0.85 9.6 0.1 10.3 11 0 0 11 11 11 4 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX43026.1 - 1.4e-06 28.2 0.2 1.5 9.0 0.0 6.1 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ORX43026.1 - 8.5e-06 25.9 21.2 0.14 12.4 3.3 7.8 6 3 2 8 8 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_22 PF18833.1 ORX43026.1 - 0.0001 22.3 0.3 0.00038 20.5 0.3 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_4 PF07721.14 ORX43026.1 - 0.0079 16.7 8.5 1e+02 4.0 0.1 7.6 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF1476 PF07345.11 ORX43026.1 - 1.2 9.6 6.1 0.28 11.6 0.5 2.7 3 0 0 3 3 2 0 ATPase inhibitor subunit zeta SQHop_cyclase_C PF13243.6 ORX43027.1 - 8e-51 173.0 0.9 3.6e-46 157.8 0.8 3.1 2 1 1 3 3 3 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ORX43027.1 - 6.4e-47 160.0 2.4 1.1e-41 142.9 0.1 3.8 3 2 1 4 4 4 3 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 ORX43027.1 - 3e-28 97.2 1.9 1.6e-09 37.3 0.0 4.5 5 0 0 5 5 5 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 ORX43027.1 - 0.00042 19.4 1.1 0.02 13.9 0.0 3.2 3 1 1 4 4 4 1 A-macroglobulin TED domain Pec_lyase PF09492.10 ORX43027.1 - 0.00061 19.2 0.3 1.6 8.0 0.0 3.8 3 1 1 4 4 4 2 Pectic acid lyase Ribosomal_L2_C PF03947.18 ORX43028.1 - 1.2e-46 158.1 4.1 1.8e-46 157.4 4.1 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ORX43028.1 - 2.6e-17 62.6 0.3 6.3e-17 61.3 0.3 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L32e PF01655.18 ORX43028.1 - 0.048 14.1 0.3 7.7 7.0 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L32 DSPc PF00782.20 ORX43029.1 - 6.3e-07 29.3 0.0 8.3e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX43029.1 - 5.7e-05 22.8 0.0 8.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX43029.1 - 0.015 15.4 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 ORX43029.1 - 0.045 13.4 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) adh_short PF00106.25 ORX43030.1 - 3.1e-24 85.5 1.0 4.8e-24 84.9 1.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX43030.1 - 4.6e-11 42.7 2.0 1.3e-10 41.3 2.0 1.6 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX43030.1 - 0.00057 19.8 3.3 0.0023 17.9 3.3 1.9 1 1 0 1 1 1 1 KR domain CobN-Mg_chel PF02514.16 ORX43030.1 - 0.00068 17.5 0.2 0.00073 17.4 0.2 1.0 1 0 0 1 1 1 1 CobN/Magnesium Chelatase CCDC14 PF15254.6 ORX43031.1 - 0.024 13.3 0.0 0.031 13.0 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 DUF5601 PF18151.1 ORX43031.1 - 0.059 13.7 0.1 0.18 12.1 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5601) VPS9 PF02204.18 ORX43032.1 - 2.1e-23 82.5 0.0 5.3e-23 81.2 0.0 1.7 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Peptidase_S8 PF00082.22 ORX43033.1 - 1.3e-32 113.3 4.5 3.1e-32 112.0 4.4 1.5 1 1 0 1 1 1 1 Subtilase family zf-C3HC4_3 PF13920.6 ORX43034.1 - 9.5e-10 38.2 3.1 1.8e-09 37.3 3.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SPRY PF00622.28 ORX43034.1 - 1.3e-08 35.0 0.0 5.2e-07 29.8 0.0 2.4 2 0 0 2 2 2 1 SPRY domain Prok-RING_4 PF14447.6 ORX43034.1 - 0.088 12.7 6.0 0.18 11.7 6.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ORX43034.1 - 0.27 11.1 5.9 0.16 11.9 1.5 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX43034.1 - 2 8.8 6.1 7.6 7.0 6.0 2.0 1 1 1 2 2 2 0 Ring finger domain Clr2 PF10383.9 ORX43034.1 - 2.2 9.0 3.9 0.84 10.4 0.1 2.2 2 1 0 2 2 2 0 Transcription-silencing protein Clr2 zf-RING_5 PF14634.6 ORX43034.1 - 6.8 6.7 6.0 13 5.8 6.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain NAD_binding_6 PF08030.12 ORX43035.1 - 2.6e-13 50.4 0.0 6.3e-13 49.1 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX43035.1 - 5e-13 49.1 0.1 1.8e-06 28.0 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain Ferric_reduct PF01794.19 ORX43035.1 - 1.1e-09 38.4 6.0 2.1e-09 37.5 6.0 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component DUF63 PF01889.17 ORX43035.1 - 0.059 13.6 2.9 0.1 12.8 2.9 1.3 1 0 0 1 1 1 0 Membrane protein of unknown function DUF63 SET PF00856.28 ORX43036.1 - 0.00088 19.7 0.0 0.0019 18.6 0.0 1.7 1 1 0 1 1 1 1 SET domain Vault_3 PF17795.1 ORX43038.1 - 0.024 14.7 0.1 38 4.4 0.0 3.1 2 1 1 3 3 3 0 Major Vault Protein Repeat domain DUF3038 PF11237.8 ORX43071.1 - 0.0014 18.7 0.0 0.004 17.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3038) Sugar_tr PF00083.24 ORX43072.1 - 3.4e-115 385.5 22.1 4.1e-115 385.2 22.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX43072.1 - 2.9e-24 85.7 21.9 2.9e-24 85.7 21.9 2.2 1 1 1 2 2 2 1 Major Facilitator Superfamily LysM PF01476.20 ORX43073.1 - 3.2e-08 33.5 0.0 6.1e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 LysM domain Sporozoite_P67 PF05642.11 ORX43073.1 - 5.5 4.9 10.0 7 4.6 10.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen EamA PF00892.20 ORX43074.1 - 3.8e-24 85.4 30.3 9e-14 51.8 7.5 3.0 3 0 0 3 3 3 2 EamA-like transporter family Imm3 PF14425.6 ORX43074.1 - 0.19 11.8 0.0 16 5.6 0.0 2.5 2 0 0 2 2 2 0 Immunity protein Imm3 BIR PF00653.21 ORX43075.1 - 6.4e-26 90.8 0.2 5.5e-14 52.6 0.2 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain zf-C3HC PF07967.13 ORX43075.1 - 0.00058 19.9 0.1 0.036 14.1 0.0 2.7 2 1 0 2 2 2 1 C3HC zinc finger-like FMO-like PF00743.19 ORX43077.1 - 1.6e-46 158.9 0.1 9.4e-26 90.3 0.0 3.4 1 1 2 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ORX43077.1 - 7.5e-23 81.2 0.0 3.6e-18 65.8 0.0 1.9 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX43077.1 - 2.7e-14 53.1 0.0 3.4e-08 33.1 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX43077.1 - 2.2e-09 37.4 0.0 4.9e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX43077.1 - 4.3e-08 33.1 0.0 2.2e-05 24.3 0.0 2.8 2 1 1 3 3 3 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ORX43077.1 - 1e-06 28.4 0.0 0.00036 19.9 0.0 2.5 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase K_oxygenase PF13434.6 ORX43077.1 - 1.1e-06 28.0 0.7 0.00099 18.3 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ORX43077.1 - 4.4e-06 26.0 0.0 1.2e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ORX43077.1 - 9.9e-06 26.0 0.0 0.0003 21.3 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX43077.1 - 2.8e-05 23.5 0.0 0.00018 20.8 0.0 2.0 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 ORX43077.1 - 4.3e-05 22.4 0.1 0.00016 20.5 0.0 1.8 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 ORX43077.1 - 0.00034 20.0 0.1 0.00062 19.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 ORX43077.1 - 0.0004 20.4 2.8 0.011 15.7 0.6 3.6 2 1 0 2 2 2 1 FAD-NAD(P)-binding IlvN PF07991.12 ORX43077.1 - 0.0028 17.3 0.0 0.0073 15.9 0.0 1.7 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_oxidored PF12831.7 ORX43077.1 - 0.005 16.3 0.0 0.0086 15.5 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 ORX43077.1 - 0.016 15.3 0.0 0.27 11.3 0.0 2.8 4 0 0 4 4 2 0 Shikimate / quinate 5-dehydrogenase Lycopene_cycl PF05834.12 ORX43077.1 - 0.029 13.4 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 ORX43077.1 - 0.044 13.7 0.1 0.14 12.0 0.1 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 ORX43077.1 - 0.053 12.3 0.0 0.085 11.6 0.0 1.3 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase NAD_binding_2 PF03446.15 ORX43077.1 - 0.082 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.6 ORX43077.1 - 0.099 13.1 0.0 4.5 7.8 0.0 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding ApbA PF02558.16 ORX43077.1 - 0.13 11.9 0.0 0.37 10.4 0.0 1.7 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF364 PF04016.12 ORX43077.1 - 0.17 11.5 0.0 1.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Putative heavy-metal chelation NAD_Gly3P_dh_N PF01210.23 ORX43077.1 - 0.19 11.7 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 ORX43077.1 - 0.24 10.4 0.1 0.49 9.4 0.1 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A Ribosomal_S15 PF00312.22 ORX43078.1 - 1.5e-30 105.2 1.9 1.5e-30 105.2 1.9 1.9 2 0 0 2 2 2 1 Ribosomal protein S15 FlxA PF14282.6 ORX43078.1 - 0.05 13.6 1.8 0.17 11.9 1.9 1.9 1 1 0 1 1 1 0 FlxA-like protein DHHA2 PF02833.14 ORX43079.1 - 3.3e-27 95.4 0.0 8.4e-27 94.1 0.0 1.7 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 ORX43079.1 - 8.1e-07 29.2 0.1 2.7e-06 27.5 0.0 1.9 2 1 0 2 2 2 1 DHH family COG6 PF06419.11 ORX43080.1 - 1.5e-178 594.9 11.0 1.7e-178 594.7 11.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 HBS1_N PF08938.10 ORX43080.1 - 0.2 12.0 2.0 2 8.8 0.2 3.2 3 0 0 3 3 3 0 HBS1 N-terminus COG2 PF06148.11 ORX43080.1 - 0.28 11.3 7.9 0.042 13.9 1.5 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 ORX43080.1 - 0.41 10.9 2.0 6.8 7.0 0.3 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) FapA PF03961.13 ORX43080.1 - 0.42 9.2 1.7 0.78 8.3 1.7 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc24 PF08286.11 ORX43080.1 - 0.6 10.4 3.0 0.44 10.8 0.4 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 LPP PF04728.13 ORX43080.1 - 1 9.8 4.4 1.1 9.7 0.5 3.1 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF1319 PF07028.11 ORX43080.1 - 1.1 9.5 4.0 1.2 9.4 0.6 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF1319) Baculo_PEP_C PF04513.12 ORX43080.1 - 1.8 8.6 11.5 0.38 10.8 2.5 3.4 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pkinase PF00069.25 ORX43081.1 - 5e-60 203.1 0.0 5.7e-60 202.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX43081.1 - 1.4e-35 122.9 0.0 1.6e-35 122.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX43081.1 - 7.8e-07 28.7 0.3 3.5e-06 26.6 0.0 2.0 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ORX43081.1 - 0.00082 19.0 1.4 0.0017 18.0 1.2 1.5 1 1 0 1 1 1 1 RIO1 family Kdo PF06293.14 ORX43081.1 - 0.005 16.2 0.5 0.0081 15.5 0.5 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX43081.1 - 0.0097 14.9 0.5 0.018 14.0 0.5 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX43081.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ORX43081.1 - 0.017 15.0 0.8 3.2 7.6 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ORX43081.1 - 0.023 13.7 0.4 0.04 12.9 0.1 1.5 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase zf-RING_2 PF13639.6 ORX43082.1 - 2.4e-11 43.8 10.4 2.4e-11 43.8 10.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ORX43082.1 - 4.2e-07 29.6 6.4 4.2e-07 29.6 6.4 2.1 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX43082.1 - 5e-07 29.9 9.9 1.4e-06 28.5 9.9 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX43082.1 - 2.2e-06 27.4 11.0 2.2e-06 27.4 11.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX43082.1 - 0.00013 21.9 11.7 0.00014 21.8 5.2 3.0 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX43082.1 - 0.00016 21.5 4.7 0.00016 21.5 4.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX43082.1 - 0.00018 21.3 8.9 0.00018 21.3 8.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX43082.1 - 0.00031 20.6 6.4 0.00031 20.6 6.4 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX43082.1 - 0.0018 18.3 6.4 0.0056 16.7 6.4 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 ORX43082.1 - 0.0051 16.9 2.9 0.011 15.8 2.9 1.6 1 0 0 1 1 1 1 KIAA1045 RING finger DUF3484 PF11983.8 ORX43082.1 - 0.024 15.8 0.3 0.11 13.6 0.1 2.2 2 0 0 2 2 1 0 Membrane-attachment and polymerisation-promoting switch RIC1 PF07064.13 ORX43082.1 - 0.07 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 RIC1 zf-RING_4 PF14570.6 ORX43082.1 - 0.17 11.7 6.3 0.44 10.4 6.3 1.8 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ORX43082.1 - 0.2 11.8 4.7 0.46 10.7 4.7 1.6 1 0 0 1 1 1 0 zinc RING finger of MSL2 PHD PF00628.29 ORX43082.1 - 0.21 11.5 8.9 0.6 10.0 8.9 1.8 1 1 0 1 1 1 0 PHD-finger Prok-RING_4 PF14447.6 ORX43082.1 - 0.91 9.4 7.5 2.8 7.9 7.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Rtf2 PF04641.12 ORX43082.1 - 1 8.7 2.9 0.7 9.2 0.1 1.9 2 0 0 2 2 2 0 Rtf2 RING-finger Prok-RING_1 PF14446.6 ORX43082.1 - 3.6 7.6 7.7 16 5.5 4.3 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 MSA-2c PF12238.8 ORX43082.1 - 4.1 7.3 5.3 2.1 8.3 3.0 1.6 2 0 0 2 2 2 0 Merozoite surface antigen 2c FANCL_C PF11793.8 ORX43082.1 - 4.2 7.6 12.7 5.4 7.3 9.9 2.6 2 1 0 2 2 2 0 FANCL C-terminal domain Cons_hypoth698 PF03601.14 ORX43083.1 - 3.9e-37 127.8 9.8 5.2e-32 111.0 6.9 2.1 2 0 0 2 2 2 2 Conserved hypothetical protein 698 Ferlin_C PF16165.5 ORX43083.1 - 0.12 12.4 0.3 0.64 10.0 0.1 2.2 1 1 0 2 2 2 0 Ferlin C-terminus GPR_Gpa2_C PF11970.8 ORX43083.1 - 0.29 11.2 2.6 1.1 9.4 0.1 2.9 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term GATA PF00320.27 ORX43084.1 - 1.2e-16 60.0 5.1 1.4e-16 59.8 5.1 1.1 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX43084.1 - 0.028 13.9 0.8 0.037 13.5 0.8 1.2 1 0 0 1 1 1 0 TFIIB zinc-binding Auto_anti-p27 PF06677.12 ORX43084.1 - 0.066 13.4 0.6 0.087 13.0 0.6 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 ORX43084.1 - 0.12 12.5 0.1 0.16 12.1 0.1 1.2 1 0 0 1 1 1 0 Zinc ribbon domain zf-RRN7 PF11781.8 ORX43084.1 - 0.15 11.8 1.2 0.28 10.9 1.2 1.5 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Mpp10 PF04006.12 ORX43085.1 - 3.7e-149 498.0 71.8 4.2e-149 497.9 71.8 1.0 1 0 0 1 1 1 1 Mpp10 protein NOA36 PF06524.12 ORX43086.1 - 1.7 7.9 3.7 2.5 7.3 3.7 1.1 1 0 0 1 1 1 0 NOA36 protein SPT2 PF08243.11 ORX43086.1 - 2.1 8.9 6.7 3.4 8.2 6.7 1.2 1 0 0 1 1 1 0 SPT2 chromatin protein USP7_ICP0_bdg PF12436.8 ORX43087.1 - 5.1e-61 206.1 0.0 2.3e-60 203.9 0.0 2.1 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 ORX43087.1 - 1.7e-52 178.1 0.5 8.1e-49 166.1 0.0 3.0 4 0 0 4 4 4 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 ORX43087.1 - 1.6e-47 162.2 0.0 2.7e-47 161.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX43087.1 - 6.4e-22 78.5 0.0 1.8e-21 77.1 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ORX43087.1 - 0.0083 15.9 0.0 0.65 9.8 0.0 3.6 5 0 0 5 5 5 1 Ubiquitin family Asn_synthase PF00733.21 ORX43088.1 - 1.4e-96 324.2 0.5 1.1e-58 199.6 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 ORX43088.1 - 6.1e-40 136.0 0.0 1e-39 135.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ORX43088.1 - 3.4e-32 111.4 0.0 7.1e-32 110.4 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ORX43088.1 - 9.7e-11 41.5 0.0 1.7e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 ORX43088.1 - 0.017 14.2 0.0 0.08 12.0 0.0 1.9 2 0 0 2 2 2 0 NAD synthase QueC PF06508.13 ORX43088.1 - 0.06 12.8 0.1 0.18 11.3 0.0 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC DUF5103 PF17116.5 ORX43089.1 - 0.02 14.2 0.6 0.037 13.3 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5103) F420_oxidored PF03807.17 ORX43089.1 - 0.1 13.2 0.2 1.2 9.8 0.0 2.5 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent DASH_Dam1 PF08653.10 ORX43089.1 - 0.4 10.5 1.8 14 5.6 0.1 2.8 3 0 0 3 3 3 0 DASH complex subunit Dam1 bZIP_1 PF00170.21 ORX43089.1 - 0.43 10.7 16.0 1.2 9.3 2.0 4.6 3 1 1 4 4 4 0 bZIP transcription factor Herpes_UL25 PF01499.16 ORX43089.1 - 0.57 8.6 8.4 0.02 13.5 1.5 1.8 1 1 1 2 2 2 0 Herpesvirus UL25 family DUF2381 PF09544.10 ORX43089.1 - 0.81 9.2 5.8 0.68 9.4 0.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2381) KLRAQ PF10205.9 ORX43089.1 - 2.6 8.3 14.2 0.25 11.6 6.1 2.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein JIP_LZII PF16471.5 ORX43089.1 - 2.6 8.3 17.0 0.71 10.1 2.6 4.2 3 2 2 5 5 5 0 JNK-interacting protein leucine zipper II YabA PF06156.13 ORX43089.1 - 3.8 8.2 17.6 15 6.3 1.9 3.6 2 2 1 3 3 3 0 Initiation control protein YabA GOLGA2L5 PF15070.6 ORX43089.1 - 5.1 5.6 25.7 49 2.4 24.3 2.4 1 1 1 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Sec2p PF06428.11 ORX43089.1 - 8.3 6.5 19.5 1.8 8.6 8.6 2.9 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p CENP-H PF05837.12 ORX43089.1 - 9.2 6.7 22.7 23 5.5 1.6 3.7 3 1 0 3 3 3 0 Centromere protein H (CENP-H) TMPIT PF07851.13 ORX43089.1 - 9.6 5.4 12.8 5 6.3 5.4 2.2 2 0 0 2 2 2 0 TMPIT-like protein DUF948 PF06103.11 ORX43089.1 - 9.6 6.5 8.3 6.8 7.0 1.0 2.9 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Methyltransf_25 PF13649.6 ORX43090.1 - 0.00035 21.2 0.0 0.00061 20.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX43090.1 - 0.00053 20.6 0.0 0.00091 19.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX43090.1 - 0.00088 19.1 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain F-box-like_2 PF13013.6 ORX43090.1 - 0.068 13.1 0.0 0.58 10.2 0.0 2.1 1 1 0 1 1 1 0 F-box-like domain Anp1 PF03452.14 ORX43092.1 - 3.7e-80 269.2 0.0 4.5e-80 268.8 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 ORX43092.1 - 6.6e-05 22.8 0.0 0.0028 17.5 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 2 Pex16 PF08610.10 ORX43093.1 - 3e-103 345.4 1.7 3.4e-103 345.2 1.7 1.0 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) PRELI PF04707.14 ORX43094.1 - 1e-45 155.4 0.1 1.2e-45 155.2 0.1 1.0 1 0 0 1 1 1 1 PRELI-like family AMP-binding PF00501.28 ORX43095.1 - 6.9e-45 153.4 0.0 8.6e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme zf-MIZ PF02891.20 ORX43097.1 - 2.6e-13 49.5 8.6 5.9e-13 48.3 8.6 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 ORX43097.1 - 1.8e-05 24.4 3.0 3.7e-05 23.5 3.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 ORX43097.1 - 0.031 14.1 5.3 0.082 12.8 5.3 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ORX43097.1 - 0.49 10.3 7.1 1.1 9.1 7.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Proteasome PF00227.26 ORX43098.1 - 1.4e-61 207.3 0.1 2e-61 206.8 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX43098.1 - 4.4e-10 39.0 0.1 1.7e-09 37.2 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Robl_LC7 PF03259.17 ORX43098.1 - 0.096 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Roadblock/LC7 domain PH_14 PF17787.1 ORX43098.1 - 0.16 11.8 0.0 6 6.7 0.0 2.2 2 0 0 2 2 2 0 PH domain zf-met PF12874.7 ORX43167.1 - 0.027 14.9 0.3 0.05 14.0 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ORX43167.1 - 0.17 12.8 1.6 0.32 11.9 0.6 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger Pox_A14 PF05767.12 ORX43169.1 - 0.93 9.7 6.9 0.18 11.9 3.4 1.7 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 cNMP_binding PF00027.29 ORX43170.1 - 9.2e-33 112.2 1.0 2e-19 69.4 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ORX43170.1 - 2.5e-07 30.3 0.3 4.1e-07 29.6 0.3 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit CDI PF02234.19 ORX43170.1 - 0.058 13.6 0.3 0.058 13.6 0.3 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 7TMR-HDED PF07697.11 ORX43170.1 - 1.1 9.3 3.9 14 5.7 0.1 2.7 3 0 0 3 3 3 0 7TM-HD extracellular PBP1_TM PF14812.6 ORX43170.1 - 2 8.8 7.2 5.1 7.5 7.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Aldedh PF00171.22 ORX43171.1 - 2.2e-119 399.0 0.0 2.7e-119 398.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Sugar_tr PF00083.24 ORX43172.1 - 3.1e-107 359.2 26.2 3.9e-107 358.9 26.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX43172.1 - 5.5e-27 94.6 40.3 8.5e-20 71.0 12.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX43172.1 - 0.00017 20.0 3.4 0.00017 20.0 3.4 2.9 1 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family TRI12 PF06609.13 ORX43172.1 - 0.00046 18.7 2.6 0.00046 18.7 2.6 2.2 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) 6PF2K PF01591.18 ORX43173.1 - 3.1e-73 245.8 0.4 1.1e-72 243.9 0.1 1.8 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX43173.1 - 3.3e-27 95.4 0.1 1.8e-21 76.7 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 ORX43173.1 - 0.00022 20.8 0.0 0.00043 19.8 0.0 1.4 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ORX43173.1 - 0.002 18.3 0.0 0.0044 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX43173.1 - 0.038 14.4 0.0 0.17 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF5128 PF17170.4 ORX43173.1 - 0.084 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 6-bladed beta-propeller AAA_18 PF13238.6 ORX43173.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain C9orf72-like PF15019.6 ORX43174.1 - 6.2e-10 39.1 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 C9orf72-like protein family C9orf72-like PF15019.6 ORX43175.1 - 0.0031 17.1 0.4 0.0061 16.1 0.1 1.7 2 0 0 2 2 2 1 C9orf72-like protein family Glyco_trans_4_4 PF13579.6 ORX43175.1 - 0.13 12.7 0.4 0.17 12.3 0.4 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain BDM PF10684.9 ORX43175.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative biofilm-dependent modulation protein ARL6IP6 PF15062.6 ORX43176.1 - 0.031 14.4 1.3 0.12 12.6 1.3 2.0 1 0 0 1 1 1 0 Haemopoietic lineage transmembrane helix Inhibitor_Mig-6 PF11555.8 ORX43177.1 - 0.015 15.4 3.0 0.029 14.4 3.0 1.5 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 Glyco_hydro_16 PF00722.21 ORX43178.1 - 6.8e-22 77.8 0.1 7.8e-22 77.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 zf-CCCH PF00642.24 ORX43179.1 - 6.5e-20 70.6 14.6 1.6e-10 40.6 0.6 2.1 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX43179.1 - 3e-09 36.6 15.4 0.00014 21.8 2.0 2.3 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ORX43179.1 - 7.8e-07 28.8 12.4 0.0015 18.2 0.4 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX43179.1 - 0.00011 22.5 7.2 0.0096 16.4 3.4 2.5 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX43179.1 - 0.01 16.5 9.9 0.27 11.9 3.9 2.0 1 1 1 2 2 2 0 Torus domain Inhibitor_I78 PF11720.8 ORX43180.1 - 8.6e-06 25.7 0.0 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX43180.1 - 0.095 13.4 0.5 0.23 12.2 0.5 1.7 1 1 0 1 1 1 0 Potato inhibitor I family Aldo_ket_red PF00248.21 ORX43181.1 - 4.3e-42 144.3 0.0 5.1e-42 144.1 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family KilA-N PF04383.13 ORX43182.1 - 0.0013 18.6 0.0 0.0027 17.5 0.0 1.6 1 1 0 1 1 1 1 KilA-N domain SICA_beta PF12878.7 ORX43184.1 - 0.088 13.0 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 SICA extracellular beta domain DUF4203 PF13886.6 ORX43187.1 - 1.5e-13 50.9 13.5 1.5e-13 50.9 13.5 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4203) zf-C3HC4_2 PF13923.6 ORX43188.1 - 3.6e-10 39.5 14.4 3.6e-10 39.5 14.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX43188.1 - 7.3e-08 32.2 16.2 7.3e-08 32.2 16.2 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX43188.1 - 1.1e-06 28.5 14.7 1.1e-06 28.5 14.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX43188.1 - 2.1e-06 27.6 10.4 2.1e-06 27.6 10.4 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX43188.1 - 4e-06 27.1 17.3 1.1e-05 25.6 14.0 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX43188.1 - 0.00019 21.3 20.3 0.00045 20.0 17.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX43188.1 - 0.00057 20.1 9.7 0.00057 20.1 9.7 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain TerY_C PF15616.6 ORX43188.1 - 0.00074 19.6 9.8 0.25 11.4 5.4 3.0 3 0 0 3 3 3 2 TerY-C metal binding domain zf-RING_6 PF14835.6 ORX43188.1 - 0.0054 16.6 5.9 0.011 15.6 5.9 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-WRNIP1_ubi PF18279.1 ORX43188.1 - 0.011 16.4 0.2 0.011 16.4 0.2 3.5 3 0 0 3 3 2 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_4 PF14570.6 ORX43188.1 - 0.011 15.5 17.7 0.19 11.6 9.1 3.3 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 ORX43188.1 - 0.026 14.4 22.3 4 7.4 18.7 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ORX43188.1 - 0.038 14.1 14.8 0.038 14.1 14.8 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING U-box PF04564.15 ORX43188.1 - 0.077 13.2 0.1 0.24 11.6 0.1 1.9 1 0 0 1 1 1 0 U-box domain SAP PF02037.27 ORX43188.1 - 0.097 12.5 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 SAP domain zf-ANAPC11 PF12861.7 ORX43188.1 - 0.11 12.6 12.2 0.12 12.5 9.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 ORX43188.1 - 0.27 11.4 12.1 0.89 9.7 12.1 2.0 1 1 0 1 1 1 0 zinc RING finger of MSL2 Peptidase_M24 PF00557.24 ORX43189.1 - 8.3e-59 198.8 0.1 1.1e-58 198.4 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ORX43189.1 - 3.9e-25 88.0 0.0 1.6e-24 86.0 0.0 1.9 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain PapJ PF14855.6 ORX43189.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone PUF PF00806.19 ORX43190.1 - 6.9e-62 201.8 12.0 7.4e-09 34.8 0.2 8.9 8 1 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 ORX43190.1 - 4.6e-05 23.8 0.0 0.63 10.4 0.0 4.2 2 1 3 6 6 6 2 CPL (NUC119) domain PriX PF18689.1 ORX43190.1 - 0.16 12.4 0.1 0.55 10.6 0.0 1.9 2 0 0 2 2 2 0 Primase X RisS_PPD PF16524.5 ORX43190.1 - 0.22 11.8 0.4 6.3 7.1 0.0 3.3 5 0 0 5 5 5 0 Periplasmic domain of Sensor histidine kinase RisS PQQ PF01011.21 ORX43191.1 - 1e-16 59.9 3.6 8.5e-06 25.5 0.0 4.4 4 0 0 4 4 4 4 PQQ enzyme repeat PQQ_2 PF13360.6 ORX43191.1 - 6.2e-15 55.4 0.1 4.4e-13 49.4 0.1 3.1 1 1 0 1 1 1 1 PQQ-like domain PQQ_3 PF13570.6 ORX43191.1 - 1.9e-08 34.5 5.9 0.6 10.7 0.1 5.9 5 1 0 5 5 5 3 PQQ-like domain PQQ_2 PF13360.6 ORX43192.1 - 9.3e-15 54.8 0.1 8.1e-06 25.6 0.0 2.6 2 1 1 3 3 3 3 PQQ-like domain PQQ PF01011.21 ORX43192.1 - 4.8e-14 51.5 1.0 0.0073 16.2 0.1 4.5 4 0 0 4 4 4 4 PQQ enzyme repeat PQQ_3 PF13570.6 ORX43192.1 - 3.9e-08 33.5 2.7 0.53 10.8 0.1 5.1 5 2 0 5 5 5 3 PQQ-like domain Hydrolase_4 PF12146.8 ORX43193.1 - 8.6e-56 188.9 0.0 9.9e-56 188.7 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX43193.1 - 3.2e-11 43.4 0.2 2.7e-09 37.1 0.2 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX43193.1 - 2e-09 38.4 0.0 2.5e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX43193.1 - 0.0061 16.1 0.1 1.5 8.3 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Thioesterase PF00975.20 ORX43193.1 - 0.032 14.3 0.1 0.072 13.2 0.1 1.5 1 1 0 1 1 1 0 Thioesterase domain LCAT PF02450.15 ORX43193.1 - 0.033 13.3 0.0 0.064 12.4 0.0 1.4 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Abhydrolase_3 PF07859.13 ORX43193.1 - 0.035 14.0 0.0 0.083 12.7 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold SMP PF04927.12 ORX43194.1 - 0.00021 21.7 0.7 0.00021 21.7 0.7 1.6 1 1 1 2 2 2 1 Seed maturation protein zf-RING_2 PF13639.6 ORX43195.1 - 3.1e-13 49.8 8.8 7.2e-13 48.6 8.8 1.7 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX43195.1 - 2.7e-10 39.8 7.1 2.7e-10 39.8 7.1 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX43195.1 - 1.3e-08 34.5 7.9 2.9e-08 33.4 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX43195.1 - 3.7e-08 33.1 8.0 9.2e-08 31.8 8.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX43195.1 - 2.8e-07 30.7 9.1 1.1e-06 28.8 9.1 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX43195.1 - 7.8e-06 25.8 6.7 1.5e-05 24.9 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain PA PF02225.22 ORX43195.1 - 8.3e-05 22.5 0.0 0.00034 20.6 0.0 1.9 2 0 0 2 2 2 1 PA domain zf-RING_UBOX PF13445.6 ORX43195.1 - 0.00018 21.4 2.6 0.00018 21.4 2.6 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ORX43195.1 - 0.0024 17.9 5.1 0.0069 16.4 5.1 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ORX43195.1 - 0.0059 16.4 9.1 0.012 15.5 9.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX43195.1 - 0.0097 15.5 5.7 0.021 14.4 5.7 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX43195.1 - 0.017 15.3 5.1 0.047 13.8 5.1 1.8 1 1 0 1 1 1 0 RING-variant domain Prok-RING_4 PF14447.6 ORX43195.1 - 0.19 11.6 9.8 0.44 10.5 9.8 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PHD PF00628.29 ORX43195.1 - 0.42 10.5 6.0 0.85 9.6 6.0 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 ORX43195.1 - 7.1 6.9 8.8 30 4.9 8.7 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain DUF1639 PF07797.14 ORX43196.1 - 0.013 15.5 0.1 0.029 14.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1639) Sds3 PF08598.11 ORX43196.1 - 0.04 13.9 2.5 0.083 12.9 2.5 1.4 1 1 0 1 1 1 0 Sds3-like EB PF01683.18 ORX43198.1 - 0.00056 20.1 33.1 0.032 14.5 10.5 3.6 2 1 1 3 3 3 3 EB module Dickkopf_N PF04706.12 ORX43198.1 - 0.012 16.0 8.6 0.012 16.0 8.6 3.1 3 0 0 3 3 3 0 Dickkopf N-terminal cysteine-rich region MAP17 PF15807.5 ORX43198.1 - 0.033 14.4 0.0 0.054 13.7 0.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Glyco_hydro_46 PF01374.18 ORX43199.1 - 2e-39 135.4 0.0 2.8e-39 134.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 46 tRNA_SAD PF07973.14 ORX43200.1 - 1e-07 31.9 0.1 2.4e-07 30.8 0.1 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 ORX43200.1 - 0.00024 19.8 0.0 0.00038 19.1 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) PPR_2 PF13041.6 ORX43201.1 - 3.4e-17 62.4 0.5 3.9e-11 43.0 0.0 3.2 3 1 1 4 4 4 2 PPR repeat family PPR_3 PF13812.6 ORX43201.1 - 1.2e-12 47.6 0.0 4.9e-06 26.5 0.0 2.5 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 ORX43201.1 - 8.3e-09 35.1 2.7 7.5e-05 22.7 0.0 4.8 4 1 0 4 4 4 1 PPR repeat PPR_1 PF12854.7 ORX43201.1 - 3.5e-06 26.6 0.4 0.7 9.6 0.0 4.2 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 ORX43201.1 - 7.6e-06 25.4 0.0 1.4e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ORX43201.1 - 0.0068 16.2 0.1 0.19 11.6 0.0 3.1 3 1 2 5 5 5 1 Mitochondrial ATPase expression CTP_transf_like PF01467.26 ORX43202.1 - 2.8e-07 30.8 0.0 1.2e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Cytidylyltransferase-like SET PF00856.28 ORX43204.1 - 5.2e-08 33.5 0.0 1.1e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 SET domain CDC27 PF09507.10 ORX43205.1 - 7.3e-43 147.5 33.6 2.5e-25 89.7 7.2 2.0 1 1 1 2 2 2 2 DNA polymerase subunit Cdc27 EBV-NA3 PF05009.12 ORX43205.1 - 0.068 12.7 1.6 9.8 5.6 0.0 2.3 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Hamartin PF04388.12 ORX43205.1 - 0.76 8.4 19.8 0.92 8.1 19.8 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4820 PF16091.5 ORX43205.1 - 5.5 6.3 10.1 14 4.9 10.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) rRNA_processing PF08524.11 ORX43206.1 - 5e-09 36.3 32.9 2.3e-06 27.7 32.9 2.1 1 1 0 1 1 1 1 rRNA processing DUF4407 PF14362.6 ORX43206.1 - 1.6 8.0 10.4 2.1 7.7 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1178 PF06676.11 ORX43206.1 - 7 7.0 10.6 1.1 9.7 5.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) LIP PF03583.14 ORX43207.1 - 9.3e-49 166.3 0.0 1.2e-48 165.9 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 ORX43207.1 - 0.024 14.1 0.5 0.95 8.9 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family TcdB_N PF12918.7 ORX43208.1 - 0.055 13.8 0.0 0.087 13.1 0.0 1.3 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain MNSV_P7B PF06692.11 ORX43210.1 - 0.071 13.1 0.5 0.15 12.1 0.5 1.6 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein Chromo PF00385.24 ORX43211.1 - 1.2e-09 38.0 2.2 3.3e-09 36.5 2.2 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF3793 PF12672.7 ORX43211.1 - 0.017 15.2 0.3 0.048 13.7 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) CK1gamma_C PF12605.8 ORX43313.1 - 1.6 10.0 6.5 0.47 11.7 1.3 2.7 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal HTH_32 PF13565.6 ORX43315.1 - 1.3e-05 25.7 0.0 1.5e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX43315.1 - 0.00038 20.4 0.0 0.00096 19.1 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 ORX43315.1 - 0.0013 18.8 0.1 0.0021 18.1 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX43315.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Terminase_5 PF06056.12 ORX43315.1 - 0.076 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) UPF0016 PF01169.19 ORX43316.1 - 1.7e-41 140.4 18.3 1.5e-20 73.3 5.4 2.1 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 Mntp PF02659.15 ORX43316.1 - 0.00021 21.1 5.0 0.00031 20.5 0.0 2.3 2 0 0 2 2 2 1 Putative manganese efflux pump CobD_Cbib PF03186.13 ORX43316.1 - 0.15 11.2 2.3 0.37 10.0 0.0 2.1 2 1 0 2 2 2 0 CobD/Cbib protein EMC3_TMCO1 PF01956.16 ORX43316.1 - 0.26 11.0 3.6 4.8 6.9 3.6 2.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LysE PF01810.18 ORX43316.1 - 0.53 9.7 12.2 0.21 11.0 1.8 2.3 2 0 0 2 2 2 0 LysE type translocator TerC PF03741.16 ORX43316.1 - 1.8 8.2 12.3 0.39 10.4 4.7 2.8 2 1 1 3 3 3 0 Integral membrane protein TerC family TcpE PF12648.7 ORX43316.1 - 5.5 7.6 8.5 1.1 9.8 0.9 2.6 3 0 0 3 3 3 0 TcpE family Kelch_5 PF13854.6 ORX43317.1 - 1.7e-06 27.9 2.2 0.048 13.7 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ORX43317.1 - 9.9e-05 22.3 4.9 0.24 11.4 0.1 3.9 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX43317.1 - 0.00059 20.0 2.0 9.3 6.7 0.0 3.7 3 0 0 3 3 3 3 Kelch motif ASC PF00858.24 ORX43317.1 - 0.00061 18.9 0.7 0.0013 17.8 0.0 1.8 2 1 0 2 2 2 1 Amiloride-sensitive sodium channel Kelch_1 PF01344.25 ORX43317.1 - 0.22 11.2 3.9 8.5 6.1 0.1 3.2 3 1 0 3 3 3 0 Kelch motif RRM_1 PF00076.22 ORX43318.1 - 9.1e-34 115.1 0.0 7e-17 61.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX43318.1 - 0.0031 17.6 0.0 0.023 14.8 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif OB_RNB PF08206.11 ORX43318.1 - 0.015 15.0 1.0 5.3 6.8 0.1 2.4 2 0 0 2 2 2 0 Ribonuclease B OB domain La PF05383.17 ORX43319.1 - 1.1e-19 70.2 0.4 3e-19 68.8 0.4 1.8 1 0 0 1 1 1 1 La domain Alb1 PF09135.11 ORX43319.1 - 1.5 9.7 13.7 5 8.1 8.3 3.1 2 0 0 2 2 2 0 Alb1 DNA_pol_phi PF04931.13 ORX43319.1 - 5 5.1 12.1 11 4.0 12.1 1.4 1 0 0 1 1 1 0 DNA polymerase phi CttA_N PF18244.1 ORX43319.1 - 9.3 6.7 7.8 14 6.2 3.8 3.2 2 1 0 2 2 2 0 Cellulose-binding protein CttA N-terminal domain ATP-synt_J PF04911.12 ORX43320.1 - 7.4e-26 89.5 0.3 8.2e-26 89.3 0.3 1.0 1 0 0 1 1 1 1 ATP synthase j chain WD40 PF00400.32 ORX43321.1 - 0.00078 20.2 14.4 0.1 13.5 0.0 5.6 6 1 0 6 6 6 2 WD domain, G-beta repeat DUF4866 PF16160.5 ORX43322.1 - 0.067 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4866) BTB PF00651.31 ORX43323.1 - 0.02 15.1 0.1 0.1 12.8 0.0 2.2 2 1 0 2 2 2 0 BTB/POZ domain Sirohm_synth_C PF14823.6 ORX43323.1 - 0.12 12.1 0.1 0.26 10.9 0.1 1.6 1 0 0 1 1 1 0 Sirohaem biosynthesis protein C-terminal Usp PF00582.26 ORX43324.1 - 1.2e-05 25.9 0.0 3.6e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 Universal stress protein family DGC PF08859.11 ORX43324.1 - 0.039 14.1 0.4 0.12 12.4 0.3 1.9 2 0 0 2 2 2 0 DGC domain Tube PF17212.3 ORX43326.1 - 0.021 14.9 0.1 0.035 14.2 0.1 1.3 1 0 0 1 1 1 0 Tail tubular protein DUF1574 PF07611.11 ORX43326.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) GHL13 PF14883.6 ORX43326.1 - 0.14 11.2 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 RVT_1 PF00078.27 ORX43327.1 - 2e-05 24.3 0.0 2.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_S19e PF01090.19 ORX43329.1 - 3.5e-60 201.6 0.2 3.9e-60 201.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e SHR-BD PF06650.12 ORX43331.1 - 1.3e-73 247.7 4.4 1.7e-72 244.0 0.3 4.0 4 1 0 4 4 4 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 ORX43331.1 - 8.2e-69 230.9 3.6 2.7e-62 209.7 0.1 2.6 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 ORX43331.1 - 8.8e-69 231.9 2.2 9.4e-66 222.0 0.2 4.1 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 ORX43331.1 - 8.3e-61 205.4 5.6 9.2e-59 198.7 0.3 4.4 4 0 0 4 4 4 2 Repeating coiled region of VPS13 Chorein_N PF12624.7 ORX43331.1 - 4.6e-17 62.2 1.2 1.8e-09 37.7 0.0 3.4 2 1 1 3 3 3 2 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 ORX43331.1 - 9.4e-08 32.3 0.0 3.6e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain Apt1 PF10351.9 ORX43331.1 - 4.7e-07 29.0 0.2 1.5e-06 27.4 0.2 1.8 2 0 0 2 2 2 1 Golgi-body localisation protein domain Glycos_transf_1 PF00534.20 ORX43332.1 - 4.5e-06 26.3 0.0 6.6e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX43332.1 - 0.00026 21.5 0.0 0.00043 20.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ORX43332.1 - 0.0011 19.4 0.0 0.002 18.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 ORX43332.1 - 0.059 13.4 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 OrfB_Zn_ribbon PF07282.11 ORX43333.1 - 0.00027 20.8 0.0 0.00042 20.2 0.0 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain PNP_UDP_1 PF01048.20 ORX43334.1 - 3.1e-40 137.9 1.9 5.9e-40 137.0 1.9 1.4 1 1 0 1 1 1 1 Phosphorylase superfamily Nsp1_C PF05064.13 ORX43335.1 - 4.5e-34 116.7 9.9 4.5e-34 116.7 9.9 1.9 2 0 0 2 2 2 1 Nsp1-like C-terminal region ATG16 PF08614.11 ORX43335.1 - 0.0071 16.6 6.8 0.0071 16.6 6.8 1.7 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Nucleoporin_FG2 PF15967.5 ORX43335.1 - 0.023 13.3 45.2 0.04 12.5 45.2 1.3 1 0 0 1 1 1 0 Nucleoporin FG repeated region TACC_C PF05010.14 ORX43335.1 - 0.027 14.3 11.0 0.019 14.7 5.1 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Tht1 PF04163.12 ORX43335.1 - 0.063 12.0 9.7 0.063 12.0 5.5 2.0 1 1 1 2 2 2 0 Tht1-like nuclear fusion protein AAA_13 PF13166.6 ORX43335.1 - 0.087 11.4 9.7 1.2 7.6 8.6 2.1 1 1 1 2 2 2 0 AAA domain Phage_GPO PF05929.11 ORX43335.1 - 0.12 11.9 5.5 0.089 12.4 3.9 1.6 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3456 PF11938.8 ORX43335.1 - 0.16 12.5 2.1 0.3 11.6 2.1 1.3 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP DUF724 PF05266.14 ORX43335.1 - 0.21 11.4 4.9 0.26 11.1 3.5 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) BLOC1_2 PF10046.9 ORX43335.1 - 0.23 11.8 13.2 0.2 12.0 4.1 3.5 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMF_DNA_bd PF12329.8 ORX43335.1 - 0.24 11.4 7.3 0.29 11.1 3.8 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding MCPsignal PF00015.21 ORX43335.1 - 0.27 11.0 4.2 2.2 8.1 0.3 2.3 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FAM76 PF16046.5 ORX43335.1 - 0.53 9.6 5.0 0.74 9.1 5.0 1.3 1 0 0 1 1 1 0 FAM76 protein DUF948 PF06103.11 ORX43335.1 - 0.57 10.5 2.2 9.3 6.6 0.1 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ORX43335.1 - 0.61 10.1 10.4 1.2 9.2 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 ORX43335.1 - 0.66 9.8 8.3 0.072 12.9 3.4 1.8 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 NPV_P10 PF05531.12 ORX43335.1 - 0.68 10.4 7.6 0.8 10.2 0.9 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 ORX43335.1 - 1.2 8.3 5.2 0.93 8.7 3.8 1.4 1 1 0 1 1 1 0 TMPIT-like protein Laminin_II PF06009.12 ORX43335.1 - 1.3 9.0 9.7 0.82 9.7 2.9 2.5 1 1 2 3 3 3 0 Laminin Domain II DUF16 PF01519.16 ORX43335.1 - 1.5 9.4 12.2 0.48 10.9 5.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 Spc7 PF08317.11 ORX43335.1 - 1.5 7.6 12.4 0.66 8.8 6.7 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 ORX43335.1 - 1.6 9.3 10.9 1.6 9.2 9.3 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 ORX43335.1 - 2.9 5.7 9.5 10 3.9 9.4 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF4201 PF13870.6 ORX43335.1 - 2.9 7.6 11.3 0.48 10.1 6.9 1.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) DASH_Duo1 PF08651.10 ORX43335.1 - 3.5 7.5 8.6 0.37 10.6 0.7 2.9 3 0 0 3 3 3 0 DASH complex subunit Duo1 Rho_Binding PF08912.11 ORX43335.1 - 6.7 7.6 11.2 1.3 9.9 3.7 3.0 2 1 1 3 3 3 0 Rho Binding Ribosomal_S21 PF01165.20 ORX43336.1 - 1.7e-13 50.1 3.4 2.7e-13 49.4 3.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S21 Cloacin_immun PF03513.14 ORX43337.1 - 0.021 15.1 0.0 0.058 13.7 0.0 1.7 1 0 0 1 1 1 0 Cloacin immunity protein Peptidase_C12 PF01088.21 ORX43338.1 - 2e-58 197.6 0.1 2.3e-58 197.4 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SUZ PF12752.7 ORX43339.1 - 1.2e-13 51.6 0.6 2.9e-13 50.3 0.6 1.7 1 0 0 1 1 1 1 SUZ domain R3H PF01424.22 ORX43339.1 - 8.3e-10 38.5 0.5 8.3e-10 38.5 0.5 2.0 2 0 0 2 2 2 1 R3H domain WD40 PF00400.32 ORX43340.1 - 9.4e-36 121.2 18.4 4.3e-08 33.7 0.8 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat NLE PF08154.12 ORX43340.1 - 1.2e-22 80.2 0.2 1.9e-22 79.5 0.2 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain ANAPC4_WD40 PF12894.7 ORX43340.1 - 0.00016 21.9 1.4 0.011 16.0 0.1 3.6 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX43340.1 - 0.014 15.3 0.1 0.15 11.9 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX43340.1 - 0.029 13.0 3.6 1.1 7.8 0.0 3.2 1 1 3 4 4 4 0 Nucleoporin Nup120/160 DUF959 PF06121.14 ORX43340.1 - 0.093 13.0 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF959) WD40_like PF17005.5 ORX43340.1 - 0.12 11.6 0.2 10 5.3 0.0 3.3 3 1 0 3 3 3 0 WD40-like domain DASH_Dad2 PF08654.10 ORX43341.1 - 2.6e-12 47.0 0.2 3.5e-12 46.6 0.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad2 Rhomboid PF01694.22 ORX43342.1 - 7.6e-33 113.6 8.0 7.6e-33 113.6 8.0 2.1 2 1 1 3 3 3 1 Rhomboid family DUF682 PF05081.12 ORX43343.1 - 0.0041 16.9 0.1 0.0083 15.9 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF682) DUF2599 PF10783.9 ORX43343.1 - 0.046 14.4 1.1 0.16 12.6 1.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) MT-A70 PF05063.14 ORX43344.1 - 3e-38 131.4 0.0 4.9e-38 130.7 0.0 1.4 1 0 0 1 1 1 1 MT-A70 GIT_CC PF16559.5 ORX43344.1 - 0.075 12.9 3.2 0.17 11.8 3.2 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0020 PF01170.18 ORX43344.1 - 0.11 12.2 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Peroxin-3 PF04882.12 ORX43344.1 - 0.31 10.0 6.2 0.45 9.4 6.2 1.2 1 0 0 1 1 1 0 Peroxin-3 Glypican PF01153.19 ORX43344.1 - 2 7.2 5.6 2.8 6.7 5.6 1.1 1 0 0 1 1 1 0 Glypican BUD22 PF09073.10 ORX43344.1 - 6.3 6.0 15.6 8.5 5.6 15.6 1.2 1 0 0 1 1 1 0 BUD22 CX9C PF16860.5 ORX43345.1 - 7.9e-07 29.0 10.8 8.2e-05 22.5 3.9 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ORX43345.1 - 1.5e-05 25.0 3.8 1.5e-05 25.0 3.8 2.5 2 1 0 2 2 2 2 CHCH domain Cmc1 PF08583.10 ORX43345.1 - 1.5 8.9 11.2 5.6 7.1 2.4 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 ORX43345.1 - 3.9 7.9 10.4 19 5.7 6.1 2.8 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 ORX43345.1 - 5.3 6.8 8.5 1.3 8.7 2.2 2.2 1 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Prok-RING_1 PF14446.6 ORX43451.1 - 1.1 9.2 7.1 1.7 8.6 1.6 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 ORX43451.1 - 1.8 8.8 3.8 12 6.1 0.3 2.5 2 0 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ORX43451.1 - 2.1 8.4 4.7 6.5 6.8 0.2 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-CCHC_6 PF15288.6 ORX43451.1 - 2.2 8.2 8.9 8 6.4 1.0 2.6 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 ORX43451.1 - 5.4 7.1 7.5 46 4.2 7.5 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-Mss51 PF13824.6 ORX43451.1 - 7.6 6.7 6.7 98 3.2 5.1 2.6 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 SWIM PF04434.17 ORX43453.1 - 7e-05 22.4 0.4 0.00017 21.2 0.4 1.7 1 0 0 1 1 1 1 SWIM zinc finger RRM_1 PF00076.22 ORX43455.1 - 0.00087 19.1 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OrfB_Zn_ribbon PF07282.11 ORX43456.1 - 0.00041 20.2 1.4 0.00041 20.2 1.4 1.6 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Transp_cyt_pur PF02133.15 ORX43457.1 - 9.4e-133 443.2 35.3 1.1e-132 443.0 35.3 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin MPS-4 PF17523.2 ORX43457.1 - 0.016 15.3 0.2 0.016 15.3 0.2 2.4 3 0 0 3 3 3 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Asp_Glu_race PF01177.22 ORX43458.1 - 3.2e-08 33.7 0.8 2e-07 31.1 0.8 2.0 1 1 0 1 1 1 1 Asp/Glu/Hydantoin racemase Amdase PF17645.1 ORX43458.1 - 0.0057 16.3 3.2 0.022 14.4 0.9 2.0 2 0 0 2 2 2 1 Arylmalonate decarboxylase MAP65_ASE1 PF03999.12 ORX43459.1 - 7.1e-26 91.1 18.9 6.5e-24 84.6 13.4 2.3 1 1 1 2 2 2 2 Microtubule associated protein (MAP65/ASE1 family) RecG_N PF17190.4 ORX43459.1 - 0.025 15.3 0.5 10 6.9 0.0 3.1 3 0 0 3 3 3 0 RecG N-terminal helical domain Sec1 PF00995.23 ORX43460.1 - 1.1e-130 437.7 1.2 1.2e-130 437.5 1.2 1.0 1 0 0 1 1 1 1 Sec1 family DUF5617 PF18493.1 ORX43460.1 - 0.02 15.0 0.2 1.3 9.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) ADH_zinc_N PF00107.26 ORX43461.1 - 2.1e-27 95.7 0.1 3.4e-27 95.0 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX43461.1 - 1.3e-16 61.8 0.1 4.9e-16 60.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX43461.1 - 0.0087 15.9 2.2 0.015 15.2 0.3 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain DUF3215 PF11503.8 ORX43461.1 - 0.043 13.7 0.6 1.1 9.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3215) MBOAT PF03062.19 ORX43462.1 - 4.9e-37 128.1 23.0 1.8e-36 126.3 22.9 2.1 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ORX43462.1 - 0.00012 22.3 1.3 0.00056 20.1 1.3 2.2 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family CLP_protease PF00574.23 ORX43462.1 - 0.033 14.1 0.5 0.052 13.4 0.5 1.2 1 0 0 1 1 1 0 Clp protease SET PF00856.28 ORX43463.1 - 7.3e-07 29.7 0.0 2.8e-06 27.8 0.0 2.1 1 1 0 1 1 1 1 SET domain Mut7-C PF01927.16 ORX43463.1 - 0.073 13.2 0.5 0.073 13.2 0.5 1.7 2 0 0 2 2 2 0 Mut7-C RNAse domain fragilysinNterm PF16376.5 ORX43463.1 - 0.079 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of fragilysin Lactamase_B_2 PF12706.7 ORX43464.1 - 5.9e-39 133.7 0.1 2.2e-37 128.6 0.1 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX43464.1 - 1.4e-14 54.3 0.0 1.3e-13 51.2 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX43464.1 - 7.6e-05 22.8 0.1 0.00027 21.0 0.0 1.9 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Hat1_N PF10394.9 ORX43465.1 - 1.6e-45 155.2 0.4 1.6e-45 155.2 0.4 2.1 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus KH_1 PF00013.29 ORX43466.1 - 2.6e-15 56.0 0.0 4e-05 23.4 0.0 5.8 7 0 0 7 7 7 3 KH domain Fumble PF03630.14 ORX43466.1 - 0.017 14.3 0.3 0.092 11.9 0.1 2.0 2 0 0 2 2 2 0 Fumble bact-PGI_C PF10432.9 ORX43469.1 - 0.13 12.3 0.0 2.6 8.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial phospho-glucose isomerase C-terminal SIS domain IDO PF01231.18 ORX43470.1 - 1.3e-134 449.2 0.0 1.4e-133 445.8 0.0 1.9 1 1 0 1 1 1 1 Indoleamine 2,3-dioxygenase AAA_2 PF07724.14 ORX43471.1 - 2.1e-41 141.9 0.0 3.4e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ORX43471.1 - 6.1e-16 59.0 0.0 1.2e-15 58.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ORX43471.1 - 6.3e-13 48.6 0.1 1.4e-12 47.4 0.1 1.6 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_22 PF13401.6 ORX43471.1 - 2.5e-06 27.8 0.2 7.5e-05 23.0 0.2 2.5 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX43471.1 - 7.8e-06 25.4 0.1 0.0023 17.4 0.1 2.7 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX43471.1 - 2.4e-05 24.4 0.3 0.00014 21.9 0.3 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX43471.1 - 7.8e-05 23.1 0.2 0.00078 19.9 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 ORX43471.1 - 0.00021 21.1 0.0 0.091 12.5 0.0 2.7 2 1 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 ORX43471.1 - 0.00024 20.9 0.2 0.0038 17.0 0.1 2.6 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ORX43471.1 - 0.0031 17.5 0.0 0.0064 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX43471.1 - 0.0045 17.5 0.0 0.0094 16.5 0.0 1.6 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 ORX43471.1 - 0.0057 16.6 0.3 0.037 14.0 0.0 2.4 3 0 0 3 3 3 1 NACHT domain IstB_IS21 PF01695.17 ORX43471.1 - 0.006 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TsaE PF02367.17 ORX43471.1 - 0.0076 16.3 0.0 0.018 15.0 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 ORX43471.1 - 0.0088 15.9 0.0 0.04 13.8 0.0 2.2 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ORX43471.1 - 0.011 15.3 0.0 0.024 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 ORX43471.1 - 0.011 15.2 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_21 PF13304.6 ORX43471.1 - 0.013 15.3 0.2 0.051 13.4 0.0 2.1 2 1 1 3 3 2 0 AAA domain, putative AbiEii toxin, Type IV TA system MCM PF00493.23 ORX43471.1 - 0.017 14.2 0.0 0.033 13.3 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Sigma54_activ_2 PF14532.6 ORX43471.1 - 0.017 15.2 0.0 0.055 13.6 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 ORX43471.1 - 0.019 14.0 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_24 PF13479.6 ORX43471.1 - 0.021 14.5 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX43471.1 - 0.024 14.8 0.0 0.05 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX43471.1 - 0.032 13.8 0.1 0.087 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX43471.1 - 0.047 13.4 0.0 0.12 12.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 ORX43471.1 - 0.067 12.4 0.0 0.16 11.1 0.0 1.6 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 ORX43471.1 - 0.087 13.4 0.0 0.25 11.9 0.0 1.8 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 ORX43471.1 - 0.089 13.2 0.0 0.38 11.1 0.0 2.2 2 0 0 2 2 1 0 RNA helicase ResIII PF04851.15 ORX43471.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX43471.1 - 0.16 11.7 0.3 0.4 10.4 0.3 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase Ribosomal_L7Ae PF01248.26 ORX43472.1 - 7.7e-28 96.1 1.1 1.4e-27 95.2 1.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Pkinase PF00069.25 ORX43473.1 - 6.5e-28 97.8 0.0 8.1e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX43473.1 - 8.6e-16 58.0 0.0 1.1e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX43473.1 - 1.3e-09 37.3 0.0 1.9e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX43473.1 - 2.1e-05 24.5 0.1 0.0039 17.1 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX43473.1 - 0.00093 18.6 0.0 0.53 9.5 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ORX43473.1 - 0.047 13.0 0.2 0.085 12.2 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 ORX43473.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC1 family Complex1_LYR_2 PF13233.6 ORX43474.1 - 5.9e-13 49.4 0.0 7.9e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ORX43474.1 - 0.00049 20.1 0.0 0.00078 19.5 0.0 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) c-SKI_SMAD_bind PF08782.10 ORX43474.1 - 0.16 12.2 0.1 0.21 11.8 0.1 1.2 1 0 0 1 1 1 0 c-SKI Smad4 binding domain AAA_16 PF13191.6 ORX43475.1 - 0.0018 18.6 0.0 0.015 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 ORX43475.1 - 0.013 15.9 0.0 0.03 14.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 ORX43475.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit AAA_25 PF13481.6 ORX43475.1 - 0.093 12.3 0.0 0.31 10.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain Importin_rep_2 PF18786.1 ORX43475.1 - 0.093 12.6 1.0 0.2 11.5 1.0 1.6 1 0 0 1 1 1 0 Importin 13 repeat RuvB_N PF05496.12 ORX43475.1 - 0.19 11.5 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RhoGAP PF00620.27 ORX43476.1 - 6.9e-36 123.4 0.4 1.7e-35 122.1 0.4 1.7 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX43476.1 - 1.3e-18 66.9 34.8 2.7e-09 37.1 7.8 4.7 4 0 0 4 4 4 3 LIM domain Laminin_II PF06009.12 ORX43476.1 - 0.031 14.3 0.1 0.055 13.5 0.1 1.4 1 0 0 1 1 1 0 Laminin Domain II Dynamin_M PF01031.20 ORX43477.1 - 1.2e-106 356.1 0.1 7.5e-106 353.5 0.0 2.2 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 ORX43477.1 - 2.3e-54 184.0 0.4 5.1e-54 182.8 0.1 1.8 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 ORX43477.1 - 6.1e-31 106.4 2.3 1.6e-30 105.1 2.3 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ORX43477.1 - 0.00016 21.7 0.4 0.0036 17.4 0.2 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase Acyltransferase PF01553.21 ORX43478.1 - 6.6e-26 90.5 0.0 9.8e-26 90.0 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase US2 PF02476.15 ORX43478.1 - 0.17 12.6 0.0 0.35 11.6 0.0 1.5 1 0 0 1 1 1 0 US2 family AF0941-like PF14591.6 ORX43478.1 - 0.24 12.0 0.0 0.4 11.3 0.0 1.2 1 0 0 1 1 1 0 AF0941-like Thiolase_N PF00108.23 ORX43480.1 - 3.4e-15 56.1 3.4 3.5e-13 49.5 2.5 3.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX43480.1 - 1.7e-12 47.1 0.2 2.2e-11 43.5 0.0 2.8 2 1 1 3 3 3 1 Thiolase, C-terminal domain SpoVAD PF07451.11 ORX43480.1 - 2.9e-05 22.9 0.9 0.028 13.1 0.2 2.3 2 0 0 2 2 2 2 Stage V sporulation protein AD (SpoVAD) ACP_syn_III PF08545.10 ORX43480.1 - 7.3e-05 22.5 0.4 0.04 13.8 0.1 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 ORX43480.1 - 0.00026 20.7 3.4 0.68 9.5 1.1 3.2 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX43480.1 - 0.00033 20.6 0.4 0.038 14.0 0.0 3.2 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Clp_N PF02861.20 ORX43480.1 - 0.053 13.6 0.1 4.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Clp amino terminal domain, pathogenicity island component Amino_oxidase PF01593.24 ORX43481.1 - 2.4e-63 215.0 0.0 3e-62 211.4 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX43481.1 - 5.8e-07 29.7 0.1 1.7e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX43481.1 - 3.7e-05 23.1 1.1 0.19 11.0 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX43481.1 - 5.1e-05 22.6 0.3 0.04 13.1 0.1 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX43481.1 - 0.0002 21.1 0.6 0.0065 16.1 0.4 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ORX43481.1 - 0.00039 19.9 0.5 0.001 18.5 0.3 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ORX43481.1 - 0.014 14.7 0.4 0.024 13.9 0.4 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ORX43481.1 - 0.016 14.3 1.0 0.025 13.7 1.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox PF00070.27 ORX43481.1 - 0.038 14.5 3.7 2.5 8.7 0.5 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF2715 PF10895.8 ORX43481.1 - 0.067 12.8 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2715) SAM_3 PF18016.1 ORX43481.1 - 0.19 11.6 0.0 0.45 10.4 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) FAD_binding_3 PF01494.19 ORX43481.1 - 0.2 10.9 0.6 0.45 9.7 0.6 1.6 1 0 0 1 1 1 0 FAD binding domain Glycophorin_A PF01102.18 ORX43482.1 - 0.087 13.1 1.4 0.15 12.3 1.4 1.3 1 0 0 1 1 1 0 Glycophorin A TMEM154 PF15102.6 ORX43482.1 - 0.098 12.6 3.1 0.13 12.2 3.1 1.2 1 0 0 1 1 1 0 TMEM154 protein family RAI16-like PF10257.9 ORX43484.1 - 7.1e-75 252.1 0.4 1.1e-74 251.5 0.4 1.3 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Nrap_D4 PF17405.2 ORX43485.1 - 1.3e-47 161.9 1.0 2.3e-47 161.1 1.0 1.3 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 ORX43485.1 - 1.3e-46 158.4 0.2 2.5e-46 157.5 0.2 1.5 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D2 PF17403.2 ORX43485.1 - 1.7e-46 157.7 0.2 7.1e-44 149.2 0.1 2.8 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D5 PF17406.2 ORX43485.1 - 3.3e-45 153.8 0.5 3.3e-43 147.2 0.3 2.5 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D3 PF17404.2 ORX43485.1 - 7.7e-43 146.3 0.0 1.4e-42 145.5 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 ORX43485.1 - 3.6e-26 92.0 0.0 8.5e-26 90.8 0.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 6 Nop PF01798.18 ORX43486.1 - 4.1e-86 288.2 0.5 1.1e-85 286.8 0.5 1.8 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ORX43486.1 - 3.5e-22 78.6 2.5 3.5e-22 78.6 2.5 2.4 3 0 0 3 3 3 1 NOP5NT (NUC127) domain DUF2315 PF10231.9 ORX43487.1 - 1.9e-38 131.3 2.6 2.5e-38 130.9 2.6 1.2 1 0 0 1 1 1 1 Apoptogenic protein 1 GATA PF00320.27 ORX43488.1 - 3.9e-14 52.0 6.2 7.5e-14 51.1 6.2 1.5 1 0 0 1 1 1 1 GATA zinc finger OrfB_Zn_ribbon PF07282.11 ORX43488.1 - 0.48 10.4 4.8 0.39 10.7 3.0 1.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain BTG PF07742.12 ORX43489.1 - 1.4e-35 121.6 0.0 1.7e-35 121.3 0.0 1.1 1 0 0 1 1 1 1 BTG family ORC2 PF04084.14 ORX43491.1 - 0.12 11.3 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 2 zf-Mss51 PF13824.6 ORX43495.1 - 0.017 15.2 0.6 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-CCHC_6 PF15288.6 ORX43495.1 - 0.053 13.4 8.0 0.6 10.0 0.6 2.7 2 0 0 2 2 2 0 Zinc knuckle Prok-RING_1 PF14446.6 ORX43495.1 - 0.3 11.1 7.2 0.88 9.5 1.6 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 ORX43495.1 - 0.75 10.0 4.9 4.7 7.4 0.5 2.7 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 ORX43495.1 - 4.3 7.5 8.5 78 3.4 8.5 2.4 1 1 0 1 1 1 0 Double zinc ribbon HTH_32 PF13565.6 ORX43527.1 - 1.8e-06 28.5 0.0 2.6e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ORX43527.1 - 7.2e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ORX43527.1 - 6.2e-05 22.9 0.0 8.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 ORX43527.1 - 7.6e-05 22.4 0.0 0.00011 21.8 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_1 PF01527.20 ORX43527.1 - 0.052 13.9 0.0 0.07 13.5 0.0 1.2 1 0 0 1 1 1 0 Transposase Terminase_5 PF06056.12 ORX43527.1 - 0.068 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) LZ_Tnp_IS481 PF13011.6 ORX43527.1 - 0.081 13.5 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 DNA_ligase_A_M PF01068.21 ORX43527.1 - 0.14 11.8 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Pectate_lyase_3 PF12708.7 ORX43528.1 - 6.2e-06 26.2 0.1 9.8e-06 25.6 0.1 1.4 1 0 0 1 1 1 1 Pectate lyase superfamily protein Bot1p PF12298.8 ORX43529.1 - 3.3e-26 92.5 0.2 5.3e-26 91.8 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein MRP-L20 PF12824.7 ORX43529.1 - 2.6e-06 27.7 0.2 2.6e-06 27.7 0.2 1.8 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 HTH_32 PF13565.6 ORX43529.1 - 0.026 15.1 0.5 0.18 12.5 0.0 2.5 3 0 0 3 3 3 0 Homeodomain-like domain Beta_elim_lyase PF01212.21 ORX43530.1 - 9.1e-72 241.8 0.0 1.4e-71 241.2 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ORX43530.1 - 2.3e-06 27.1 0.0 3.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ORX43530.1 - 0.027 13.4 0.0 0.052 12.5 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ORX43530.1 - 0.027 13.8 0.0 0.094 12.0 0.0 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family cwf21 PF08312.12 ORX43531.1 - 4.9e-13 49.0 5.6 4.9e-13 49.0 5.6 2.7 2 1 0 2 2 2 1 cwf21 domain Homoserine_dh PF00742.19 ORX43531.1 - 0.0079 16.1 0.1 0.01 15.8 0.1 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase DUF5595 PF18077.1 ORX43531.1 - 3 8.0 11.4 0.15 12.2 2.3 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF5595) CTNNBL PF08216.11 ORX43532.1 - 5e-37 126.2 1.4 1.9e-36 124.4 1.4 2.1 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear Arm_3 PF16186.5 ORX43532.1 - 0.02 14.5 0.1 0.066 12.8 0.1 1.9 1 0 0 1 1 1 0 Atypical Arm repeat IF2_N PF04760.15 ORX43532.1 - 0.078 12.8 0.2 0.078 12.8 0.2 3.2 4 0 0 4 4 4 0 Translation initiation factor IF-2, N-terminal region zf-C2H2 PF00096.26 ORX43533.1 - 0.018 15.5 8.3 0.059 13.8 3.8 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ORX43533.1 - 0.019 15.3 2.2 0.047 14.0 2.2 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX43533.1 - 0.021 15.6 8.7 0.66 11.0 4.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 ORX43533.1 - 0.022 14.4 10.7 0.22 11.2 1.4 2.9 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Spt46 PF17734.1 ORX43533.1 - 0.034 14.0 0.1 0.048 13.5 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 46 DUF629 PF04780.12 ORX43533.1 - 0.078 11.5 2.3 0.41 9.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF629) DUF1386 PF07138.11 ORX43534.1 - 0.00077 18.8 0.0 0.0017 17.7 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1386) Ank_5 PF13857.6 ORX43535.1 - 1.5e-31 108.0 4.2 6.2e-10 39.1 0.0 5.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX43535.1 - 5.8e-30 103.3 3.3 1.7e-06 28.5 0.1 7.3 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX43535.1 - 4.4e-29 100.9 2.8 4.3e-11 43.3 0.1 5.5 4 1 1 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX43535.1 - 4.1e-21 72.8 5.8 0.013 16.0 0.0 8.6 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 ORX43535.1 - 7.3e-20 70.5 12.3 0.00038 20.8 0.0 8.7 8 0 0 8 8 8 4 Ankyrin repeat HlyD_2 PF12700.7 ORX43535.1 - 1.8 7.2 7.4 0.29 9.8 2.0 2.1 2 0 0 2 2 2 0 HlyD family secretion protein Arm-DNA-bind_2 PF12167.8 ORX43536.1 - 0.027 14.4 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Arm DNA-binding domain RRM_1 PF00076.22 ORX43537.1 - 0.2 11.5 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ORX43538.1 - 1.1e-40 137.3 0.0 1.2e-14 53.9 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_9 PF18444.1 ORX43538.1 - 0.069 13.0 0.0 34 4.4 0.0 3.2 3 1 0 3 3 3 0 RNA recognition motif Mito_fiss_reg PF05308.11 ORX43538.1 - 1.2 9.2 11.1 1.7 8.7 11.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator RNase_H2_suC PF08615.11 ORX43539.1 - 3e-07 30.7 0.0 3.6e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) V1R PF03402.14 ORX43539.1 - 0.082 12.5 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 Vomeronasal organ pheromone receptor family, V1R DUF678 PF05077.12 ORX43540.1 - 0.0093 16.1 0.3 0.01 15.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF678) zinc_ribbon_9 PF14369.6 ORX43540.1 - 0.029 14.6 0.2 0.047 13.9 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon Chitin_synth_2 PF03142.15 ORX43542.1 - 1.3e-223 743.4 0.5 1.9e-223 742.9 0.5 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX43542.1 - 3.9e-54 184.0 0.4 5.9e-54 183.4 0.4 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ORX43542.1 - 1.6e-16 60.2 0.0 2.9e-10 40.1 0.0 3.8 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 ORX43542.1 - 4.2e-13 49.7 0.0 4.9e-12 46.2 0.0 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX43542.1 - 1.6e-12 47.8 1.4 1.6e-12 47.8 1.4 3.2 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX43542.1 - 2.5e-05 24.2 0.0 0.012 15.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX43542.1 - 0.00016 21.2 0.0 0.0016 18.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 Helicase_C_2 PF13307.6 ORX43542.1 - 0.049 13.8 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain ABC_tran_CTD PF16326.5 ORX43544.1 - 0.045 14.0 1.4 0.07 13.4 1.4 1.3 1 1 0 1 1 1 0 ABC transporter C-terminal domain Flg_new PF09479.10 ORX43545.1 - 0.006 16.7 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 Listeria-Bacteroides repeat domain (List_Bact_rpt) COX14 PF14880.6 ORX43546.1 - 0.019 14.8 0.2 0.033 14.0 0.2 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c assembly GATA PF00320.27 ORX43548.1 - 9.9e-31 105.1 23.3 3.8e-16 58.4 4.6 2.5 3 0 0 3 3 3 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX43548.1 - 2.8e-08 33.1 6.4 0.0003 20.2 0.5 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX43548.1 - 1.9e-05 24.7 7.0 0.14 12.3 0.3 3.1 2 1 1 3 3 3 2 Zinc ribbon domain zf-RRN7 PF11781.8 ORX43548.1 - 2.1e-05 24.1 6.4 0.00042 19.9 0.6 2.7 2 1 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Auto_anti-p27 PF06677.12 ORX43548.1 - 9.6e-05 22.5 7.7 0.03 14.5 0.4 2.7 3 0 0 3 3 3 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 ORX43548.1 - 0.00021 21.2 9.8 0.0042 17.1 9.9 2.8 1 1 0 1 1 1 1 Double zinc ribbon TDP43_N PF18694.1 ORX43548.1 - 0.00074 19.3 0.1 0.82 9.6 0.0 2.2 2 0 0 2 2 2 2 Transactive response DNA-binding protein N-terminal domain ArfGap PF01412.18 ORX43548.1 - 0.0011 19.0 5.3 0.16 12.0 1.0 2.2 1 1 0 2 2 2 2 Putative GTPase activating protein for Arf eIF-5_eIF-2B PF01873.17 ORX43548.1 - 0.077 12.9 5.5 0.56 10.1 0.5 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 Elf1 PF05129.13 ORX43548.1 - 0.17 12.0 5.3 0.68 10.0 1.7 2.5 1 1 0 2 2 2 0 Transcription elongation factor Elf1 like Prim_Zn_Ribbon PF08273.12 ORX43548.1 - 0.2 12.0 12.4 0.41 11.0 0.7 3.1 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Rubredoxin_2 PF18073.1 ORX43548.1 - 0.21 11.4 9.1 27 4.6 0.1 4.4 4 0 0 4 4 4 0 Rubredoxin metal binding domain Nudix_N_2 PF14803.6 ORX43548.1 - 0.24 11.3 12.7 0.43 10.6 1.0 4.0 3 2 0 3 3 3 0 Nudix N-terminal zf-ribbon_3 PF13248.6 ORX43548.1 - 0.48 9.9 17.5 6.7 6.3 0.2 4.5 4 1 0 4 4 4 0 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ORX43548.1 - 0.48 11.2 7.6 5.8 7.7 4.9 3.0 1 1 2 3 3 3 0 zinc-ribbon family zf-CHY PF05495.12 ORX43548.1 - 0.53 10.8 5.2 4.7 7.8 4.9 2.3 1 1 1 2 2 2 0 CHY zinc finger zf-Sec23_Sec24 PF04810.15 ORX43548.1 - 0.73 9.9 9.9 0.28 11.3 0.9 2.7 3 1 0 3 3 2 0 Sec23/Sec24 zinc finger HypA PF01155.19 ORX43548.1 - 1.3 9.0 6.3 54 3.9 0.1 2.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Apocytochr_F_N PF16639.5 ORX43548.1 - 1.9 8.7 3.9 28 5.0 0.0 2.9 1 1 2 3 3 3 0 Apocytochrome F, N-terminal Rpr2 PF04032.16 ORX43548.1 - 3.8 7.9 12.2 47 4.4 9.8 2.9 1 1 2 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ribosomal_L32p PF01783.23 ORX43548.1 - 4.3 7.7 15.1 11 6.4 2.5 4.1 2 1 1 3 3 3 0 Ribosomal L32p protein family Zn_ribbon_recom PF13408.6 ORX43548.1 - 5.3 7.6 13.1 13 6.4 2.3 3.2 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain zf-NADH-PPase PF09297.11 ORX43548.1 - 6.3 6.6 16.9 8.4 6.1 0.4 4.8 5 0 0 5 5 5 0 NADH pyrophosphatase zinc ribbon domain Tnp_zf-ribbon_2 PF13842.6 ORX43548.1 - 7.1 7.5 12.4 15 6.5 0.6 3.7 2 2 1 3 3 3 0 DDE_Tnp_1-like zinc-ribbon zinc_ribbon_9 PF14369.6 ORX43548.1 - 8.9 6.7 8.2 5.3 7.4 0.5 2.9 3 1 0 3 3 3 0 zinc-ribbon DUF866 PF05907.13 ORX43549.1 - 5e-58 195.4 1.4 5.7e-58 195.2 1.4 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) RNHCP PF12647.7 ORX43549.1 - 0.11 12.5 1.5 2.6 8.1 0.1 2.2 1 1 1 2 2 2 0 RNHCP domain Mannosyl_trans3 PF11051.8 ORX43551.1 - 2.2e-40 138.8 0.0 1.1e-38 133.2 0.0 2.3 1 1 0 1 1 1 1 Mannosyltransferase putative 2OG-FeII_Oxy_3 PF13640.6 ORX43552.1 - 7.7e-05 23.5 0.0 0.00097 20.0 0.0 2.2 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Oxidored_q3 PF00499.20 ORX43553.1 - 0.094 12.4 0.2 0.18 11.6 0.2 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 APG17 PF04108.12 ORX43554.1 - 1.7e-64 218.4 18.3 1.9e-64 218.3 18.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 PriCT_2 PF08707.11 ORX43554.1 - 0.052 13.9 0.2 9.4 6.7 0.0 3.0 3 0 0 3 3 3 0 Primase C terminal 2 (PriCT-2) Snf7 PF03357.21 ORX43555.1 - 6.3e-51 172.4 14.3 7.3e-51 172.2 14.3 1.0 1 0 0 1 1 1 1 Snf7 DASH_Dad4 PF08650.10 ORX43555.1 - 0.032 14.2 1.0 0.032 14.2 1.0 2.0 2 0 0 2 2 2 0 DASH complex subunit Dad4 GlcNAc-1_reg PF18440.1 ORX43555.1 - 0.19 12.0 3.1 0.32 11.3 1.3 2.1 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain DUF2730 PF10805.8 ORX43555.1 - 1.1 9.4 5.2 8.1 6.6 0.6 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) betaPIX_CC PF16523.5 ORX43555.1 - 3.8 7.4 8.5 0.11 12.3 1.3 2.2 2 1 0 2 2 2 0 betaPIX coiled coil Med9 PF07544.13 ORX43555.1 - 4.8 7.4 7.3 7.1 6.8 0.7 3.0 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DAGK_cat PF00781.24 ORX43556.1 - 2.2e-30 104.9 0.1 3.1e-30 104.4 0.1 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain HMG_box PF00505.19 ORX43558.1 - 2.4e-19 69.5 1.2 2.4e-19 69.5 1.2 2.3 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX43558.1 - 3.4e-11 43.6 1.4 3.4e-11 43.6 1.4 2.0 2 0 0 2 2 2 1 HMG-box domain HMG_box_5 PF14887.6 ORX43558.1 - 2.4e-05 24.2 0.6 2.4e-05 24.2 0.6 1.7 2 0 0 2 2 2 1 HMG (high mobility group) box 5 HTH_24 PF13412.6 ORX43558.1 - 0.011 15.2 0.0 0.022 14.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2992 PF11208.8 ORX43558.1 - 0.29 11.4 14.0 0.49 10.6 14.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) CDC73_C PF05179.14 ORX43559.1 - 3.4e-46 156.8 1.1 6.2e-46 156.0 1.1 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N PF16050.5 ORX43559.1 - 1.2e-13 51.0 4.8 5.8e-11 42.3 0.5 2.5 1 1 1 2 2 2 2 Paf1 complex subunit CDC73 N-terminal Alanine_zipper PF11839.8 ORX43559.1 - 0.13 12.6 0.2 0.28 11.6 0.2 1.5 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Mito_carr PF00153.27 ORX43560.1 - 5.5e-20 71.1 1.6 1.3e-12 47.4 0.0 3.2 3 0 0 3 3 3 2 Mitochondrial carrier protein NDUF_B12 PF08122.12 ORX43560.1 - 0.35 10.9 4.3 3.2 7.9 0.5 3.3 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family RRM_1 PF00076.22 ORX43562.1 - 0.00019 21.2 0.5 3.1 7.7 0.0 3.6 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX43562.1 - 0.068 13.0 0.3 7.3 6.5 0.4 3.0 2 1 0 2 2 2 0 Occluded RNA-recognition motif PI3Ka PF00613.20 ORX43563.1 - 1.1e-59 201.0 0.5 1.7e-59 200.3 0.5 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ORX43563.1 - 3e-53 181.2 0.2 4.4e-50 170.8 0.0 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 ORX43563.1 - 0.00058 19.3 0.0 0.00091 18.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) PI3K_C2 PF00792.24 ORX43564.1 - 1.7e-24 86.4 0.0 1.9e-24 86.1 0.0 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 C2 PF00168.30 ORX43564.1 - 0.0058 16.9 0.0 0.007 16.6 0.0 1.1 1 0 0 1 1 1 1 C2 domain GCFC PF07842.12 ORX43565.1 - 4.4e-72 243.0 21.6 4.4e-72 243.0 21.6 1.6 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 ORX43565.1 - 4.2e-13 49.0 5.8 9.5e-13 47.8 5.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX43565.1 - 2.9e-07 30.5 4.4 2.9e-07 30.5 4.4 2.4 2 0 0 2 2 2 1 G-patch domain PACT_coil_coil PF10495.9 ORX43567.1 - 3e-09 37.3 3.4 4.3e-09 36.8 0.6 2.3 2 0 0 2 2 2 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein Amidohydro_1 PF01979.20 ORX43568.1 - 3.6e-37 128.5 0.0 4.4e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX43568.1 - 8.9e-13 48.5 0.5 4.2e-08 33.1 0.0 2.4 1 1 1 2 2 2 2 Amidohydrolase family DRY_EERY PF09750.9 ORX43569.1 - 3.2e-12 46.9 2.9 8.2e-12 45.6 2.9 1.9 1 1 0 1 1 1 1 Alternative splicing regulator RNA_pol_Rpb1_2 PF00623.20 ORX43569.1 - 0.0089 16.3 0.0 0.029 14.6 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 PAF-AH_p_II PF03403.13 ORX43570.1 - 1.7e-07 30.1 0.0 2e-07 29.9 0.0 1.0 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II RRM_1 PF00076.22 ORX43571.1 - 7.3e-15 54.6 0.0 9.9e-15 54.1 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX43571.1 - 0.0031 17.5 0.0 0.0057 16.6 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ORX43571.1 - 0.034 14.0 0.0 0.039 13.8 0.0 1.1 1 0 0 1 1 1 0 Occluded RNA-recognition motif Phosducin PF02114.16 ORX43573.1 - 2.3e-21 76.0 1.1 3.2e-21 75.5 1.0 1.3 1 1 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ORX43573.1 - 1.1e-05 25.4 0.3 1.8e-05 24.6 0.3 1.4 1 0 0 1 1 1 1 Thioredoxin zf-C4H2 PF10146.9 ORX43573.1 - 0.021 15.2 1.5 0.033 14.5 1.5 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein HutP PF09021.11 ORX43573.1 - 0.067 13.5 0.2 0.16 12.3 0.2 1.6 1 0 0 1 1 1 0 HutP Velvet PF11754.8 ORX43576.1 - 4.6e-38 131.6 3.3 3e-27 96.2 1.7 2.3 1 1 1 2 2 2 2 Velvet factor Mito_fiss_reg PF05308.11 ORX43577.1 - 0.41 10.7 5.6 0.64 10.1 5.6 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator AAA PF00004.29 ORX43578.1 - 3.7e-12 46.8 0.0 7.3e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX43578.1 - 1.1e-06 28.7 0.2 7e-06 26.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 ORX43578.1 - 6e-06 26.3 0.0 9.8e-05 22.3 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_22 PF13401.6 ORX43578.1 - 6.8e-06 26.4 0.0 2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ORX43578.1 - 2.9e-05 23.8 0.0 6.8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX43578.1 - 3.8e-05 23.7 0.0 8.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ORX43578.1 - 8.4e-05 23.1 0.0 0.00033 21.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX43578.1 - 0.00033 21.1 0.0 0.0012 19.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ORX43578.1 - 0.0012 19.2 0.3 0.0062 16.9 0.0 2.5 3 0 0 3 3 1 1 RNA helicase AAA_30 PF13604.6 ORX43578.1 - 0.0016 18.2 0.0 0.0035 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX43578.1 - 0.0024 17.6 0.0 0.0073 16.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 ORX43578.1 - 0.0033 17.7 0.0 0.01 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_33 PF13671.6 ORX43578.1 - 0.0035 17.5 0.0 0.0093 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ORX43578.1 - 0.0044 17.2 0.7 0.0081 16.3 0.1 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ORX43578.1 - 0.013 15.2 0.0 0.056 13.2 0.0 2.0 1 1 0 1 1 1 0 IstB-like ATP binding protein T2SSE PF00437.20 ORX43578.1 - 0.02 13.9 0.0 0.046 12.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 ORX43578.1 - 0.021 14.1 0.0 0.044 13.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_25 PF13481.6 ORX43578.1 - 0.024 14.2 0.0 0.067 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ORX43578.1 - 0.027 14.9 0.7 0.11 12.9 0.1 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ORX43578.1 - 0.035 13.3 0.0 0.07 12.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain TsaE PF02367.17 ORX43578.1 - 0.037 14.0 0.0 0.076 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ORX43578.1 - 0.044 14.3 0.1 0.88 10.1 0.0 3.0 3 0 0 3 3 3 0 ABC transporter AAA_28 PF13521.6 ORX43578.1 - 0.049 13.9 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX43578.1 - 0.051 13.5 0.0 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 ORX43578.1 - 0.072 13.0 0.0 0.26 11.2 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_19 PF13245.6 ORX43578.1 - 0.075 13.4 1.3 0.39 11.1 0.4 2.7 2 1 0 2 2 1 0 AAA domain TIP49 PF06068.13 ORX43578.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain RsgA_GTPase PF03193.16 ORX43578.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Pkinase PF00069.25 ORX43579.1 - 1.7e-47 162.0 0.1 2.2e-47 161.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX43579.1 - 1.3e-23 83.6 0.1 1.7e-23 83.3 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ORX43579.1 - 5.9e-06 26.5 0.1 2.4e-05 24.6 0.1 2.1 1 0 0 1 1 1 1 FHA domain Kinase-like PF14531.6 ORX43579.1 - 0.0066 15.8 0.1 0.0094 15.3 0.1 1.3 1 0 0 1 1 1 1 Kinase-like YrbL-PhoP_reg PF10707.9 ORX43579.1 - 0.054 13.0 0.0 0.11 12.0 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL Aim19 PF10315.9 ORX43580.1 - 1.5e-23 83.3 4.4 1.7e-23 83.1 4.4 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Tmemb_14 PF03647.13 ORX43580.1 - 0.003 18.3 0.7 0.0048 17.6 0.7 1.3 1 0 0 1 1 1 1 Transmembrane proteins 14C DUF1644 PF07800.12 ORX43582.1 - 0.00068 19.7 1.4 0.001 19.2 1.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1644) NifQ PF04891.12 ORX43582.1 - 3.1 8.1 9.5 1.6 9.0 1.8 2.3 2 0 0 2 2 2 0 NifQ SAM_decarbox PF01536.16 ORX43681.1 - 0.031 13.3 0.0 0.034 13.1 0.0 1.0 1 0 0 1 1 1 0 Adenosylmethionine decarboxylase Ribosomal_S25 PF03297.15 ORX43682.1 - 9.2e-26 90.0 0.3 1e-25 89.9 0.3 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 ORX43682.1 - 0.0047 16.5 0.3 0.0065 16.0 0.3 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding EMP70 PF02990.16 ORX43684.1 - 1.3e-207 690.7 4.3 1.6e-207 690.3 4.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 Sec2p PF06428.11 ORX43685.1 - 4.2e-07 29.8 3.1 4.2e-07 29.8 3.1 2.3 2 1 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF1664 PF07889.12 ORX43685.1 - 0.37 10.8 4.1 0.64 10.1 1.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DegS PF05384.11 ORX43685.1 - 0.51 9.8 4.6 0.92 9.0 1.8 2.5 2 1 0 2 2 2 0 Sensor protein DegS Cortex-I_coil PF09304.10 ORX43685.1 - 1.6 9.0 8.4 0.32 11.2 0.2 3.3 2 2 1 3 3 3 0 Cortexillin I, coiled coil RNA_pol_Rpb6 PF01192.22 ORX43686.1 - 8.7e-17 60.8 0.2 1.4e-16 60.1 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb6 Forkhead PF00250.18 ORX43687.1 - 1.4e-31 108.5 0.3 2.3e-31 107.9 0.3 1.3 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 ORX43687.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 linker histone H1 and H5 family GDA1_CD39 PF01150.17 ORX43688.1 - 9.1e-85 284.9 0.0 1.1e-84 284.6 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 ORX43688.1 - 0.012 15.0 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family PHO4 PF01384.20 ORX43689.1 - 9.2e-121 403.0 15.8 1.1e-120 402.8 15.8 1.0 1 0 0 1 1 1 1 Phosphate transporter family Sugar_tr PF00083.24 ORX43690.1 - 6.8e-98 328.5 31.0 7.8e-98 328.3 31.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX43690.1 - 1.2e-25 90.2 47.8 1.8e-21 76.4 23.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily NUDIX PF00293.28 ORX43691.1 - 1.2e-06 28.6 0.1 7.7e-05 22.7 0.1 2.7 1 1 0 1 1 1 1 NUDIX domain DUF1445 PF07286.12 ORX43692.1 - 0.14 12.1 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1445) Peptidase_C2 PF00648.21 ORX43693.1 - 1.8e-42 145.4 0.0 2.9e-42 144.7 0.0 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease Calpain_III PF01067.22 ORX43693.1 - 8.4e-19 68.2 0.3 5.7e-05 23.4 0.0 4.8 3 2 0 3 3 3 3 Calpain large subunit, domain III MIT PF04212.18 ORX43693.1 - 2.9e-09 36.9 1.2 3.7e-08 33.3 0.1 2.3 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 ORX43693.1 - 0.37 11.0 4.5 1.6 9.0 0.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX43693.1 - 7.4 6.3 6.3 19 5.0 0.1 3.7 4 0 0 4 4 4 0 TPR repeat B2-adapt-app_C PF09066.10 ORX43694.1 - 0.02 15.0 1.1 0.036 14.2 0.2 2.0 2 1 0 2 2 2 0 Beta2-adaptin appendage, C-terminal sub-domain GCV_H PF01597.19 ORX43696.1 - 7.9e-46 154.9 0.5 9.2e-46 154.7 0.5 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 ORX43696.1 - 2.1e-05 24.4 0.1 3.5e-05 23.7 0.1 1.3 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 ORX43696.1 - 5.4e-05 22.9 0.3 0.00025 20.8 0.5 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Inhibitor_I9 PF05922.16 ORX43697.1 - 3e-09 37.4 0.1 5.8e-09 36.5 0.1 1.4 1 1 0 1 1 1 1 Peptidase inhibitor I9 SPDY PF03771.16 ORX43697.1 - 0.18 11.7 0.2 3.8 7.5 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF317) Beta-lactamase PF00144.24 ORX43698.1 - 3.9e-41 141.4 0.3 5.6e-41 140.9 0.3 1.2 1 0 0 1 1 1 1 Beta-lactamase Cytochrom_C PF00034.21 ORX43699.1 - 2.5e-13 50.9 0.2 3.8e-13 50.4 0.2 1.3 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 ORX43699.1 - 4.2e-09 36.6 5.0 5.5e-08 33.0 5.0 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 ORX43699.1 - 0.0012 18.6 0.5 0.018 14.7 0.2 2.2 2 0 0 2 2 2 1 Cytochrome c-550 domain CCP_MauG PF03150.14 ORX43699.1 - 0.015 15.9 0.0 0.016 15.8 0.0 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase NCBP3 PF10309.9 ORX43700.1 - 2.8e-05 23.9 0.0 4.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 ORX43700.1 - 4.5e-05 23.4 0.0 8.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 RNA binding domain Paf1 PF03985.13 ORX43701.1 - 6e-43 147.4 2.1 6.7e-43 147.3 2.1 1.0 1 0 0 1 1 1 1 Paf1 Peptidase_A22B PF04258.13 ORX43702.1 - 2e-81 273.6 13.8 2.5e-81 273.3 13.8 1.0 1 0 0 1 1 1 1 Signal peptide peptidase SPP PF06550.11 ORX43702.1 - 0.00044 19.8 12.3 0.0011 18.5 12.3 1.8 1 1 0 1 1 1 1 Signal-peptide peptidase, presenilin aspartyl protease CrgA PF06781.12 ORX43702.1 - 0.12 12.4 0.0 0.12 12.4 0.0 2.9 2 1 0 2 2 2 0 Cell division protein CrgA DUF4366 PF14283.6 ORX43702.1 - 2.2 8.3 9.1 3.5 7.6 5.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Carboxyl_trans PF01039.22 ORX43703.1 - 4e-186 619.5 0.0 4.6e-186 619.3 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ORX43703.1 - 0.00023 20.8 0.4 0.0016 18.0 0.0 2.1 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) Myosin_head PF00063.21 ORX43704.1 - 1.2e-264 879.7 0.1 1.2e-264 879.7 0.1 1.6 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 ORX43704.1 - 3.9e-26 91.3 1.0 3.9e-26 91.3 1.0 3.1 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 ORX43704.1 - 1.2e-10 40.2 32.1 4.6e-05 22.9 0.1 7.4 7 0 0 7 7 7 3 IQ calmodulin-binding motif Fez1 PF06818.15 ORX43704.1 - 0.0071 16.8 14.2 0.0071 16.8 14.2 2.8 1 1 0 2 2 1 1 Fez1 AAA_22 PF13401.6 ORX43704.1 - 0.019 15.2 1.1 0.055 13.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ORX43704.1 - 0.04 13.8 1.2 0.064 13.2 0.0 1.9 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 ORX43704.1 - 0.12 12.7 0.0 0.12 12.7 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain ABC_tran PF00005.27 ORX43704.1 - 0.13 12.8 6.4 0.19 12.3 0.1 2.8 2 0 0 2 2 2 0 ABC transporter zf-C4H2 PF10146.9 ORX43704.1 - 0.4 10.9 11.2 1.4 9.2 11.2 2.0 1 0 0 1 1 1 0 Zinc finger-containing protein SlyX PF04102.12 ORX43704.1 - 2.2 9.0 22.9 0.64 10.7 8.7 4.2 2 1 1 3 3 3 0 SlyX Tropomyosin_1 PF12718.7 ORX43704.1 - 2.3 8.4 20.1 8.2 6.6 18.9 2.4 1 1 1 2 2 2 0 Tropomyosin like DivIC PF04977.15 ORX43704.1 - 3.6 7.4 17.6 1.1 9.1 0.4 3.7 2 1 1 3 3 3 0 Septum formation initiator RabGAP-TBC PF00566.18 ORX43706.1 - 2.7e-56 190.6 1.0 5.2e-56 189.7 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain CdvA PF18822.1 ORX43706.1 - 0.0071 16.2 0.5 0.0071 16.2 0.5 3.1 1 1 1 3 3 3 1 CdvA-like coiled-coil domain MAT1 PF06391.13 ORX43706.1 - 0.17 11.7 14.6 0.36 10.6 14.6 1.5 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Neur_chan_memb PF02932.16 ORX43706.1 - 0.3 11.1 1.1 0.62 10.1 1.1 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AA_kinase PF00696.28 ORX43707.1 - 3.2e-38 131.7 1.2 4.5e-38 131.2 1.2 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 ORX43707.1 - 2e-15 56.5 2.3 3.8e-15 55.6 0.1 2.7 3 0 0 3 3 3 1 PUA domain Moricin PF06451.11 ORX43707.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.8 3 0 0 3 3 3 0 Moricin WD40 PF00400.32 ORX43708.1 - 3.4e-25 87.8 7.7 3.7e-09 37.0 0.2 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX43708.1 - 1e-08 35.4 1.0 0.0024 18.2 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ORX43708.1 - 4.7e-06 26.4 0.3 8.4e-06 25.6 0.3 1.4 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 ORX43708.1 - 0.0025 16.8 0.2 0.75 8.7 0.0 2.7 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ORX43708.1 - 0.17 11.8 1.4 3.1 7.9 0.0 3.4 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Siva PF05458.12 ORX43709.1 - 0.11 12.2 2.6 0.16 11.7 2.6 1.2 1 0 0 1 1 1 0 Cd27 binding protein (Siva) ADH_zinc_N PF00107.26 ORX43710.1 - 3.5e-17 62.6 0.0 5.5e-17 62.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX43710.1 - 8.8e-05 22.4 0.0 0.00023 21.0 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF1752 PF08550.10 ORX43711.1 - 4e-14 52.1 3.1 7.6e-14 51.3 3.1 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) PSRT PF07636.11 ORX43711.1 - 3.4 7.4 12.8 3.7 7.3 0.3 3.9 4 0 0 4 4 4 0 PSRT FH2 PF02181.23 ORX43712.1 - 1.7e-80 270.9 1.4 1.7e-80 270.9 1.4 2.9 2 1 1 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ORX43712.1 - 7e-31 107.2 0.6 2.2e-30 105.6 0.0 2.3 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX43712.1 - 2.5e-15 56.6 4.1 2.5e-15 56.6 4.1 3.0 2 1 2 4 4 4 1 Diaphanous FH3 Domain zf-RING_2 PF13639.6 ORX43713.1 - 1.9e-09 37.7 10.0 3.6e-09 36.8 10.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 ORX43713.1 - 1.7e-06 28.0 8.5 7.6e-06 25.9 8.5 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ORX43713.1 - 4.7e-06 26.4 10.2 9.5e-06 25.4 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX43713.1 - 1.7e-05 25.0 15.9 0.00023 21.4 15.9 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX43713.1 - 3.8e-05 23.4 10.7 7.2e-05 22.6 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX43713.1 - 4.3e-05 23.2 3.5 0.0001 22.0 3.5 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ORX43713.1 - 6e-05 22.8 5.3 0.0001 22.0 5.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX43713.1 - 9.3e-05 22.4 7.7 0.00022 21.2 7.7 1.7 1 1 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX43713.1 - 0.00048 19.9 8.4 0.001 18.9 8.4 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ORX43713.1 - 0.0017 18.5 6.0 0.0033 17.6 6.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ORX43713.1 - 0.11 12.5 7.8 0.25 11.4 7.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ORX43713.1 - 0.38 10.4 7.4 0.77 9.4 7.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 ORX43713.1 - 0.48 10.8 8.9 0.97 9.8 8.9 1.5 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 ORX43713.1 - 1.2 9.3 8.3 3.3 7.9 8.3 1.8 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 ORX43713.1 - 2.9 7.8 5.9 11 5.9 5.9 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Tim10_DDP PF02953.15 ORX43714.1 - 2.5e-17 62.3 1.6 2.9e-17 62.1 1.6 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF842 PF05811.13 ORX43714.1 - 0.035 13.8 2.3 0.13 12.0 1.9 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) DUF2116 PF09889.9 ORX43714.1 - 0.36 10.9 2.1 0.5 10.4 0.7 1.8 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Arm PF00514.23 ORX43716.1 - 2.3e-06 27.4 3.7 4.6e-05 23.3 0.0 4.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ORX43716.1 - 7.1e-05 22.9 3.8 0.0037 17.3 0.1 3.6 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX43716.1 - 0.00046 20.6 1.1 0.15 12.6 0.0 5.1 5 1 0 5 5 5 1 HEAT-like repeat ParcG PF10274.9 ORX43716.1 - 0.0021 18.2 0.1 0.037 14.1 0.0 2.8 2 1 0 2 2 2 1 Parkin co-regulated protein RIX1 PF08167.12 ORX43716.1 - 0.0037 17.0 0.4 1.3 8.8 0.1 2.5 2 0 0 2 2 2 2 rRNA processing/ribosome biogenesis HEAT PF02985.22 ORX43716.1 - 0.0089 16.2 10.6 0.2 12.0 0.0 6.3 7 0 0 7 7 7 1 HEAT repeat CCDC32 PF14989.6 ORX43716.1 - 0.19 11.7 1.5 0.47 10.5 0.1 2.2 1 1 1 2 2 2 0 Coiled-coil domain containing 32 DUF4184 PF13803.6 ORX43718.1 - 0.029 14.1 0.6 0.037 13.8 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4184) DUF577 PF04510.12 ORX43719.1 - 0.15 12.0 0.0 0.17 11.7 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF577) HNH_3 PF13392.6 ORX43721.1 - 6.8e-10 38.5 0.6 1.2e-09 37.7 0.6 1.4 1 0 0 1 1 1 1 HNH endonuclease CUE PF02845.16 ORX43722.1 - 4.5e-10 39.0 0.3 1.3e-09 37.5 0.3 1.9 1 0 0 1 1 1 1 CUE domain Rsa3 PF14615.6 ORX43722.1 - 0.54 9.9 3.0 26 4.5 0.3 3.1 3 0 0 3 3 3 0 Ribosome-assembly protein 3 Urb2 PF10441.9 ORX43724.1 - 1.7e-22 80.4 0.4 1.7e-22 80.4 0.4 4.0 3 1 0 3 3 3 1 Urb2/Npa2 family DUF1904 PF08921.11 ORX43724.1 - 0.0069 16.7 0.1 0.11 12.8 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF1904) Bac_DnaA PF00308.18 ORX43724.1 - 0.04 13.7 0.1 0.11 12.3 0.1 1.7 1 0 0 1 1 1 0 Bacterial dnaA protein FliL PF03748.14 ORX43724.1 - 0.055 14.1 0.6 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 Flagellar basal body-associated protein FliL PTPA PF03095.15 ORX43726.1 - 2.9e-124 414.4 0.2 3.3e-124 414.2 0.2 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Pro_isomerase PF00160.21 ORX43727.1 - 1.3e-49 168.5 0.0 1.5e-49 168.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD OSR1_C PF12202.8 ORX43841.1 - 0.018 15.2 0.6 0.051 13.8 0.1 2.0 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain RGS PF00615.19 ORX43842.1 - 5.7e-16 58.9 4.1 1.3e-15 57.7 4.1 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain RGS-like PF09128.11 ORX43842.1 - 0.027 14.2 2.7 0.051 13.3 1.5 1.9 1 1 1 2 2 2 0 Regulator of G protein signalling-like domain BLOC1_2 PF10046.9 ORX43844.1 - 4.3e-05 23.7 3.0 0.00012 22.3 2.7 1.9 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 MCPsignal PF00015.21 ORX43844.1 - 0.00011 22.1 8.1 0.00016 21.6 8.1 1.2 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF812 PF05667.11 ORX43844.1 - 0.0013 17.7 4.8 0.0016 17.5 4.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF1664 PF07889.12 ORX43844.1 - 0.0014 18.7 7.0 0.022 14.8 1.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) GAS PF13851.6 ORX43844.1 - 0.0019 17.6 3.5 0.0056 16.1 3.5 1.7 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding EzrA PF06160.12 ORX43844.1 - 0.0025 16.1 2.4 0.0032 15.7 2.4 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DHR10 PF18595.1 ORX43844.1 - 0.0031 17.5 10.0 0.0078 16.3 3.9 2.1 1 1 1 2 2 2 1 Designed helical repeat protein 10 domain UPF0242 PF06785.11 ORX43844.1 - 0.0047 17.1 4.3 0.0058 16.8 4.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus NBD94 PF16830.5 ORX43844.1 - 0.0068 16.8 0.3 0.011 16.1 0.3 1.3 1 0 0 1 1 1 1 Nucleotide-Binding Domain 94 of RH SOAR PF16533.5 ORX43844.1 - 0.0078 16.2 3.7 0.94 9.5 0.3 2.2 2 0 0 2 2 2 1 STIM1 Orai1-activating region DUF4201 PF13870.6 ORX43844.1 - 0.0078 16.0 3.1 0.013 15.2 1.4 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) COG5 PF10392.9 ORX43844.1 - 0.008 16.4 2.6 0.016 15.4 2.5 1.6 1 1 0 1 1 1 1 Golgi transport complex subunit 5 Spc7 PF08317.11 ORX43844.1 - 0.0081 15.1 7.5 0.019 13.9 7.5 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein Allexi_40kDa PF05549.11 ORX43844.1 - 0.01 15.4 1.5 0.012 15.2 1.5 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein APG6_N PF17675.1 ORX43844.1 - 0.012 16.2 5.1 0.021 15.3 4.7 1.6 1 1 1 2 2 2 0 Apg6 coiled-coil region TACC_C PF05010.14 ORX43844.1 - 0.012 15.4 2.7 0.016 15.0 2.7 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF885 PF05960.11 ORX43844.1 - 0.012 15.2 1.2 0.014 15.1 1.2 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Taxilin PF09728.9 ORX43844.1 - 0.013 14.8 1.6 0.013 14.8 1.6 1.8 1 1 0 1 1 1 0 Myosin-like coiled-coil protein IFT57 PF10498.9 ORX43844.1 - 0.014 14.4 5.8 0.017 14.1 5.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 ORX43844.1 - 0.014 15.4 7.4 0.051 13.6 7.3 1.8 1 1 0 1 1 1 0 Laminin Domain II DUF1515 PF07439.11 ORX43844.1 - 0.015 15.4 0.9 0.57 10.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) COG7 PF10191.9 ORX43844.1 - 0.015 13.5 2.5 0.018 13.3 2.5 1.1 1 0 0 1 1 1 0 Golgi complex component 7 (COG7) DASH_Duo1 PF08651.10 ORX43844.1 - 0.016 15.0 3.5 0.2 11.4 0.1 2.5 2 1 1 3 3 2 0 DASH complex subunit Duo1 Filament PF00038.21 ORX43844.1 - 0.016 14.8 4.7 0.02 14.5 4.7 1.2 1 0 0 1 1 1 0 Intermediate filament protein KASH_CCD PF14662.6 ORX43844.1 - 0.016 15.0 3.2 0.02 14.7 3.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH MAD PF05557.13 ORX43844.1 - 0.017 13.5 3.7 0.02 13.3 3.7 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Sec8_exocyst PF04048.14 ORX43844.1 - 0.017 15.0 1.9 0.021 14.7 1.2 1.5 1 1 0 1 1 1 0 Sec8 exocyst complex component specific domain Gp58 PF07902.11 ORX43844.1 - 0.018 13.3 3.9 0.022 13.1 3.9 1.1 1 0 0 1 1 1 0 gp58-like protein TMPIT PF07851.13 ORX43844.1 - 0.021 14.1 4.2 0.025 13.8 4.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein F_actin_bind PF08919.10 ORX43844.1 - 0.021 14.9 2.2 0.036 14.2 2.2 1.4 1 1 0 1 1 1 0 F-actin binding FapA PF03961.13 ORX43844.1 - 0.026 13.1 1.5 0.031 12.9 1.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3584 PF12128.8 ORX43844.1 - 0.027 12.0 4.3 0.035 11.6 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG17 PF04108.12 ORX43844.1 - 0.03 13.5 3.3 0.037 13.1 3.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 CREPT PF16566.5 ORX43844.1 - 0.031 14.4 3.8 0.11 12.7 1.2 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour AAA_13 PF13166.6 ORX43844.1 - 0.033 12.8 3.7 0.041 12.5 3.7 1.1 1 0 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 ORX43844.1 - 0.035 12.0 2.8 0.039 11.9 2.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ran-binding PF05508.11 ORX43844.1 - 0.038 13.0 3.3 0.054 12.5 3.3 1.1 1 0 0 1 1 1 0 RanGTP-binding protein DUF4756 PF15948.5 ORX43844.1 - 0.041 13.7 0.5 0.085 12.7 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4756) LUC7 PF03194.15 ORX43844.1 - 0.043 13.5 2.1 0.052 13.2 2.1 1.1 1 0 0 1 1 1 0 LUC7 N_terminus RasGAP_C PF03836.15 ORX43844.1 - 0.046 13.9 1.7 0.065 13.4 1.3 1.4 1 1 0 1 1 1 0 RasGAP C-terminus DUF948 PF06103.11 ORX43844.1 - 0.05 13.9 8.4 0.17 12.2 5.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) CorA PF01544.18 ORX43844.1 - 0.052 12.9 1.5 1.3 8.3 0.2 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein SlyX PF04102.12 ORX43844.1 - 0.058 14.0 7.3 0.31 11.7 2.4 2.4 1 1 1 2 2 2 0 SlyX FlaC_arch PF05377.11 ORX43844.1 - 0.059 13.8 2.4 1.2 9.6 0.2 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Tektin PF03148.14 ORX43844.1 - 0.062 12.0 6.6 0.059 12.1 3.1 1.8 1 1 1 2 2 2 0 Tektin family DUF724 PF05266.14 ORX43844.1 - 0.064 13.1 5.6 0.12 12.2 2.8 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF745 PF05335.13 ORX43844.1 - 0.072 12.8 10.9 0.24 11.1 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF148 PF02520.17 ORX43844.1 - 0.076 13.1 8.1 0.27 11.3 1.8 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF148 Mod_r PF07200.13 ORX43844.1 - 0.078 13.1 3.5 0.13 12.4 3.5 1.4 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Fib_alpha PF08702.10 ORX43844.1 - 0.083 13.1 7.1 0.16 12.2 1.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tropomyosin PF00261.20 ORX43844.1 - 0.091 12.1 6.6 0.18 11.2 6.6 1.4 1 1 0 1 1 1 0 Tropomyosin Vps51 PF08700.11 ORX43844.1 - 0.094 12.8 3.2 11 6.2 0.4 3.1 2 1 0 2 2 2 0 Vps51/Vps67 HrpB7 PF09486.10 ORX43844.1 - 0.097 13.1 9.3 0.3 11.5 1.7 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Tweety PF04906.13 ORX43844.1 - 0.1 11.3 3.9 0.12 11.0 3.9 1.1 1 0 0 1 1 1 0 Tweety Baculo_PEP_C PF04513.12 ORX43844.1 - 0.11 12.5 7.2 0.6 10.1 0.9 1.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HeLo PF14479.6 ORX43844.1 - 0.11 12.3 2.5 0.14 12.0 2.5 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation Not3 PF04065.15 ORX43844.1 - 0.12 11.8 4.8 0.15 11.5 4.8 1.1 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF2203 PF09969.9 ORX43844.1 - 0.12 13.2 2.2 0.17 12.6 1.8 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Sec5 PF15469.6 ORX43844.1 - 0.14 12.0 4.7 0.88 9.4 0.6 2.0 1 1 1 2 2 2 0 Exocyst complex component Sec5 YkyA PF10368.9 ORX43844.1 - 0.14 11.8 3.2 0.27 10.9 3.2 1.5 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein DUF4962 PF16332.5 ORX43844.1 - 0.14 10.6 0.8 0.17 10.4 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4962) TMF_TATA_bd PF12325.8 ORX43844.1 - 0.16 12.2 3.7 0.39 10.9 3.2 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding RPW8 PF05659.11 ORX43844.1 - 0.17 11.6 1.7 2.1 8.0 0.1 2.1 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Syntaxin-6_N PF09177.11 ORX43844.1 - 0.19 12.3 3.7 0.68 10.5 3.1 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF16 PF01519.16 ORX43844.1 - 0.19 12.2 4.6 0.36 11.3 4.6 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 Prefoldin PF02996.17 ORX43844.1 - 0.22 11.4 7.2 0.52 10.2 1.1 2.3 2 0 0 2 2 2 0 Prefoldin subunit Sec34 PF04136.15 ORX43844.1 - 0.22 11.4 6.5 0.23 11.4 2.2 2.0 1 1 1 2 2 2 0 Sec34-like family Uds1 PF15456.6 ORX43844.1 - 0.24 11.6 5.0 0.45 10.7 4.9 1.5 1 1 0 1 1 1 0 Up-regulated During Septation Syntaxin_2 PF14523.6 ORX43844.1 - 0.25 11.7 6.5 5.3 7.5 6.5 2.2 1 1 0 1 1 1 0 Syntaxin-like protein DUF3450 PF11932.8 ORX43844.1 - 0.31 10.3 9.2 0.5 9.6 9.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) AIP3 PF03915.13 ORX43844.1 - 0.31 10.1 5.9 0.38 9.8 5.9 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 FliJ PF02050.16 ORX43844.1 - 0.33 11.2 5.5 2 8.7 5.4 2.0 1 1 1 2 2 2 0 Flagellar FliJ protein DUF3829 PF12889.7 ORX43844.1 - 0.36 10.2 4.0 0.89 9.0 3.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) BORCS6 PF10157.9 ORX43844.1 - 0.38 11.0 7.2 0.53 10.5 4.7 1.9 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 6 NPV_P10 PF05531.12 ORX43844.1 - 0.39 11.2 7.2 0.5 10.9 4.3 2.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 ORX43844.1 - 0.4 10.9 8.9 0.75 10.0 8.9 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Snapin_Pallidin PF14712.6 ORX43844.1 - 0.44 11.0 4.2 0.89 10.0 3.9 1.7 1 1 0 1 1 1 0 Snapin/Pallidin CLZ PF16526.5 ORX43844.1 - 0.46 10.9 2.5 20 5.7 0.1 2.7 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TBCC_N PF16752.5 ORX43844.1 - 0.49 10.9 5.0 0.98 9.9 5.0 1.6 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain YabA PF06156.13 ORX43844.1 - 0.49 11.1 2.7 17 6.1 0.4 2.1 1 1 1 2 2 2 0 Initiation control protein YabA PspA_IM30 PF04012.12 ORX43844.1 - 0.58 9.7 9.2 2.4 7.7 9.2 1.8 1 1 0 1 1 1 0 PspA/IM30 family YlbD_coat PF14071.6 ORX43844.1 - 0.6 10.4 4.6 1.2 9.4 2.2 1.9 1 1 1 2 2 2 0 Putative coat protein LPP PF04728.13 ORX43844.1 - 0.61 10.5 7.6 10 6.6 0.0 2.8 2 1 1 3 3 2 0 Lipoprotein leucine-zipper Fzo_mitofusin PF04799.13 ORX43844.1 - 0.61 9.6 8.1 4.2 6.9 2.1 2.1 1 1 1 2 2 2 0 fzo-like conserved region CENP-H PF05837.12 ORX43844.1 - 0.65 10.4 10.2 0.66 10.4 6.5 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) BORCS7 PF16088.5 ORX43844.1 - 0.77 10.1 7.0 5.3 7.4 5.5 2.1 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 7 Prefoldin_2 PF01920.20 ORX43844.1 - 0.78 9.7 5.9 2.3 8.2 1.3 2.2 1 1 0 2 2 2 0 Prefoldin subunit KxDL PF10241.9 ORX43844.1 - 0.78 10.1 5.7 5 7.5 1.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein FadA PF09403.10 ORX43844.1 - 1.1 9.7 4.5 6.1 7.4 4.1 2.1 1 1 0 1 1 1 0 Adhesion protein FadA eIF3_N PF09440.10 ORX43844.1 - 1.1 9.7 5.8 4.6 7.7 5.8 1.8 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain COG2 PF06148.11 ORX43844.1 - 1.3 9.1 5.8 3.7 7.7 0.5 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RasGEF_N_2 PF14663.6 ORX43844.1 - 1.3 9.4 4.2 4.4 7.7 0.3 2.2 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain XhlA PF10779.9 ORX43844.1 - 1.4 9.1 5.1 4.1 7.7 0.5 2.2 1 1 1 2 2 2 0 Haemolysin XhlA DUF1993 PF09351.10 ORX43844.1 - 1.5 9.0 5.6 2 8.5 1.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1993) DASH_Dad2 PF08654.10 ORX43844.1 - 1.5 9.3 7.1 11 6.5 5.1 2.3 1 1 1 2 2 2 0 DASH complex subunit Dad2 Cluap1 PF10234.9 ORX43844.1 - 2.1 7.7 8.2 17 4.7 7.7 1.9 1 1 0 1 1 1 0 Clusterin-associated protein-1 zf-C2H2 PF00096.26 ORX43845.1 - 5.6e-10 39.1 34.4 2.8e-05 24.3 0.7 4.9 4 1 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX43845.1 - 1.1e-06 28.8 12.2 4.4e-05 23.7 1.2 4.9 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX43845.1 - 0.00011 22.7 29.0 0.00068 20.3 0.5 5.0 5 0 0 5 5 5 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX43845.1 - 0.00087 19.9 11.8 0.019 15.6 0.4 3.6 1 1 2 3 3 3 1 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX43845.1 - 0.015 15.3 0.3 0.015 15.3 0.3 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX43845.1 - 0.022 15.1 12.2 0.023 15.0 7.0 2.3 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ORX43845.1 - 0.055 13.8 15.1 0.082 13.2 2.0 4.3 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 ORX43845.1 - 0.076 13.7 0.8 0.076 13.7 0.8 3.3 2 2 1 3 3 3 0 TRAF-type zinc finger HEXIM PF15313.6 ORX43845.1 - 0.11 12.6 0.1 0.23 11.6 0.1 1.5 1 0 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein RRM_1 PF00076.22 ORX43846.1 - 3.1e-05 23.7 0.0 6.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX43846.1 - 0.0023 17.8 0.0 0.0046 16.8 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif DUF883 PF05957.13 ORX43846.1 - 0.0087 16.6 1.3 0.02 15.5 0.9 1.9 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF883) Nup35_RRM_2 PF14605.6 ORX43846.1 - 0.023 14.7 0.0 0.2 11.7 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif YtxH PF12732.7 ORX43846.1 - 0.41 11.2 4.0 1.3 9.6 2.6 2.3 1 1 1 2 2 2 0 YtxH-like protein Epimerase PF01370.21 ORX43849.1 - 7.2e-26 91.1 0.1 9.6e-26 90.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX43849.1 - 4.4e-14 52.6 0.3 6e-14 52.2 0.3 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ORX43849.1 - 3.2e-12 46.1 0.0 4.4e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ORX43849.1 - 6.1e-10 39.3 0.0 1.4e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ORX43849.1 - 6.7e-10 38.5 0.2 9.2e-10 38.1 0.2 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ORX43849.1 - 3.7e-05 23.0 0.2 0.00018 20.8 0.2 2.1 1 1 0 1 1 1 1 Male sterility protein adh_short PF00106.25 ORX43849.1 - 0.00014 21.4 0.0 0.0019 17.7 0.0 2.6 2 1 1 3 3 3 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ORX43849.1 - 0.0002 20.6 0.1 0.00032 19.9 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ORX43849.1 - 0.00022 21.2 0.0 0.00051 20.0 0.0 1.6 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ORX43849.1 - 0.0038 17.5 0.0 0.0082 16.4 0.0 1.8 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Chitin_synth_2 PF03142.15 ORX43850.1 - 3.6e-275 913.6 0.0 5.7e-275 912.9 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX43850.1 - 4.7e-13 49.6 0.0 1.2e-11 45.0 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX43850.1 - 4.9e-11 42.9 2.8 4.9e-11 42.9 2.8 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX43850.1 - 0.00094 18.7 0.0 0.059 12.8 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX43850.1 - 0.031 14.1 0.0 0.26 11.1 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 2 E1-E2_ATPase PF00122.20 ORX43851.1 - 2.4e-48 164.0 3.3 2.4e-48 164.0 3.3 3.7 5 0 0 5 5 5 1 E1-E2 ATPase Hydrolase PF00702.26 ORX43851.1 - 1.7e-23 84.0 0.3 5.3e-23 82.4 0.1 2.0 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX43851.1 - 1.1e-11 44.2 0.0 3e-11 42.8 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 ORX43851.1 - 0.007 16.1 12.1 0.018 14.7 6.0 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 ORX43851.1 - 0.01 15.6 0.1 0.057 13.1 0.1 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX43851.1 - 0.014 15.5 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Moricin PF06451.11 ORX43851.1 - 0.027 14.2 0.1 4 7.3 0.0 2.7 2 0 0 2 2 2 0 Moricin Apolipoprotein PF01442.18 ORX43852.1 - 1.2e-06 28.5 10.7 0.00031 20.7 10.9 2.8 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain Perilipin PF03036.16 ORX43852.1 - 0.00019 20.6 22.9 0.00052 19.2 0.8 4.1 1 1 1 2 2 2 1 Perilipin family Phasin PF05597.11 ORX43852.1 - 0.036 14.1 8.9 0.39 10.7 0.0 3.9 3 1 1 4 4 4 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Baculo_PEP_C PF04513.12 ORX43852.1 - 0.27 11.3 25.1 3 7.9 4.4 4.3 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3708 PF12501.8 ORX43852.1 - 4.7 7.0 7.8 25 4.6 0.3 2.9 1 1 2 3 3 3 0 Phosphate ATP-binding cassette transporter DUF4709 PF15821.5 ORX43852.1 - 6.9 7.0 9.0 1.1 9.6 2.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) Syntaxin_2 PF14523.6 ORX43852.1 - 9.9 6.6 11.4 13 6.2 1.8 3.6 1 1 2 3 3 3 0 Syntaxin-like protein DUF3767 PF12597.8 ORX43853.1 - 3.9e-29 100.4 0.1 4.6e-29 100.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) INSIG PF07281.12 ORX43853.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) ATP-synt PF00231.19 ORX43854.1 - 2e-73 247.5 5.2 2.3e-73 247.4 5.2 1.0 1 0 0 1 1 1 1 ATP synthase Lactamase_B_6 PF16661.5 ORX43855.1 - 5.3e-67 225.0 0.1 1e-66 224.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 ORX43855.1 - 5e-31 108.2 1.6 1.6e-25 90.3 0.0 2.9 3 1 1 4 4 4 2 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 ORX43855.1 - 1.4e-16 60.8 0.1 4.1e-16 59.3 0.0 1.9 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 ORX43855.1 - 1.2e-12 47.6 0.0 2.9e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 ORX43855.1 - 3.9e-05 23.7 0.0 8.1e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX43855.1 - 8.2e-05 22.2 0.1 0.00034 20.2 0.1 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX43855.1 - 0.019 14.9 0.1 0.065 13.1 0.1 1.9 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Pex24p PF06398.11 ORX43856.1 - 1.3e-06 27.6 7.4 1.8e-06 27.2 7.4 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin RasGEF PF00617.19 ORX43858.1 - 5.1e-44 150.6 0.5 9.6e-44 149.7 0.5 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX43858.1 - 3.3e-08 33.7 0.5 9.8e-08 32.2 0.5 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif MFS_1_like PF12832.7 ORX43859.1 - 6.7e-61 206.3 4.9 7.8e-61 206.0 4.9 1.0 1 0 0 1 1 1 1 MFS_1 like family Nuc_H_symport PF03825.16 ORX43859.1 - 3.6e-15 55.9 12.2 1.2e-14 54.1 5.8 2.1 2 0 0 2 2 2 2 Nucleoside H+ symporter MFS_1 PF07690.16 ORX43859.1 - 5.7e-14 51.8 23.9 7.6e-13 48.1 13.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX43859.1 - 0.0019 16.6 4.1 0.011 14.1 0.0 2.3 1 1 1 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family DUF1772 PF08592.11 ORX43859.1 - 4 7.7 8.0 0.93 9.8 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1772) ATG22 PF11700.8 ORX43859.1 - 6 5.4 15.5 9.4 4.7 11.0 2.5 2 1 0 2 2 2 0 Vacuole effluxer Atg22 like Na_sulph_symp PF00939.19 ORX43860.1 - 9.4e-102 341.5 22.2 1.1e-101 341.3 22.2 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX43860.1 - 1.1e-18 67.4 33.4 5.3e-11 42.3 8.3 2.8 1 1 2 3 3 3 2 Citrate transporter DUF1129 PF06570.11 ORX43860.1 - 1.3 8.5 0.0 1.3 8.5 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1129) KH_1 PF00013.29 ORX43861.1 - 7.9e-07 28.8 0.1 0.027 14.3 0.0 2.4 2 0 0 2 2 2 2 KH domain CRAL_TRIO PF00650.20 ORX43862.1 - 1.1e-21 77.2 0.0 1.8e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain zf-RING_2 PF13639.6 ORX43864.1 - 7.1e-11 42.3 8.8 1.4e-10 41.3 8.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX43864.1 - 3.4e-09 36.3 6.3 9.2e-09 34.9 6.3 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX43864.1 - 2.7e-07 30.8 5.7 6.1e-07 29.6 5.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX43864.1 - 2.3e-06 27.3 8.5 4.8e-06 26.3 8.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX43864.1 - 3.8e-06 26.6 9.8 7.9e-06 25.6 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 ORX43864.1 - 0.00047 20.1 0.0 0.00094 19.2 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-RING_5 PF14634.6 ORX43864.1 - 0.0069 16.3 6.8 0.013 15.4 6.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX43864.1 - 0.019 15.0 5.1 0.043 13.9 5.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ORX43864.1 - 0.032 14.1 9.8 0.056 13.3 9.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX43864.1 - 0.12 12.0 9.2 0.22 11.2 9.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 ORX43864.1 - 0.18 11.6 6.0 0.34 10.7 5.8 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ORX43864.1 - 0.18 11.8 7.3 0.27 11.3 6.1 1.9 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING-like PF08746.11 ORX43864.1 - 3.9 7.9 8.9 2.7 8.4 6.8 1.8 2 0 0 2 2 2 0 RING-like domain Prok-RING_4 PF14447.6 ORX43864.1 - 8.2 6.4 11.4 14 5.6 11.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF202 PF02656.15 ORX43865.1 - 2.1e-15 56.9 0.3 2.1e-15 56.9 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Abhydrolase_9_N PF15420.6 ORX43865.1 - 0.00038 20.5 0.5 0.0005 20.1 0.5 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus Cation_ATPase_C PF00689.21 ORX43865.1 - 0.0014 18.4 1.1 0.0018 18.0 1.1 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Frag1 PF10277.9 ORX43865.1 - 0.0096 15.5 6.3 0.012 15.1 5.5 1.4 2 0 0 2 2 2 1 Frag1/DRAM/Sfk1 family Phage_holin_3_6 PF07332.11 ORX43865.1 - 7.6 6.6 6.9 0.73 9.9 2.5 1.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TPR_2 PF07719.17 ORX43866.1 - 1.1e-12 47.0 6.9 0.00028 20.8 0.1 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX43866.1 - 1.7e-09 37.7 3.3 2.3e-05 24.8 0.5 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX43866.1 - 4.1e-09 35.9 8.8 0.00065 19.4 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX43866.1 - 1.1e-08 35.4 5.8 4.1e-08 33.6 1.3 2.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX43866.1 - 2.6e-07 30.9 4.8 0.00032 20.9 0.7 3.4 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX43866.1 - 5.9e-07 29.1 1.1 0.13 12.4 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX43866.1 - 1.1e-06 29.2 3.5 2.6e-05 24.8 0.5 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX43866.1 - 2.3e-06 27.6 2.4 0.05 13.7 0.0 3.4 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 ORX43866.1 - 2.4e-05 24.2 3.4 0.12 12.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX43866.1 - 2.5e-05 24.0 4.6 0.0096 15.8 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX43866.1 - 6.4e-05 23.3 1.8 0.056 14.1 0.1 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX43866.1 - 0.00014 22.0 3.6 0.00053 20.2 0.7 2.7 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 ORX43866.1 - 0.0019 17.7 2.1 0.034 13.6 0.1 2.1 1 1 1 2 2 2 1 Coatomer epsilon subunit TPR_17 PF13431.6 ORX43866.1 - 0.0021 18.3 3.9 2.2 8.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 ORX43866.1 - 0.0048 16.9 0.9 0.039 14.0 0.3 2.7 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain Alkyl_sulf_dimr PF14863.6 ORX43866.1 - 0.0088 16.5 3.5 0.023 15.1 0.5 2.1 1 1 1 2 2 2 1 Alkyl sulfatase dimerisation ChAPs PF09295.10 ORX43866.1 - 0.017 14.2 0.2 0.019 14.0 0.2 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_20 PF14561.6 ORX43866.1 - 0.037 14.3 4.8 0.13 12.6 1.1 2.5 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX43866.1 - 0.067 12.9 9.2 0.42 10.3 0.9 4.1 4 1 1 5 5 5 0 TPR repeat PPR PF01535.20 ORX43866.1 - 0.13 12.5 2.9 6 7.4 0.0 3.2 4 0 0 4 4 2 0 PPR repeat AAA PF00004.29 ORX43867.1 - 9.8e-46 155.5 0.2 3.4e-45 153.7 0.0 2.0 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX43867.1 - 9.8e-11 41.3 0.1 2.8e-10 39.8 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ORX43867.1 - 4.6e-10 39.3 0.1 3.8e-09 36.4 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ORX43867.1 - 8.1e-10 38.8 0.1 2.6e-09 37.2 0.1 1.9 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX43867.1 - 4.9e-09 36.5 0.0 1.3e-08 35.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX43867.1 - 4.6e-08 33.6 0.1 1.5e-05 25.5 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX43867.1 - 3.8e-05 24.0 1.5 0.0092 16.3 1.5 2.6 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 ORX43867.1 - 7.7e-05 22.0 0.0 0.00015 21.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ORX43867.1 - 0.00013 22.0 0.0 0.00039 20.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain TsaE PF02367.17 ORX43867.1 - 0.00029 20.8 0.1 0.017 15.2 0.0 2.4 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ORX43867.1 - 0.00037 21.0 0.0 0.0018 18.8 0.0 2.0 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ORX43867.1 - 0.00039 20.2 0.0 0.0011 18.7 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ORX43867.1 - 0.00095 19.5 0.0 0.0021 18.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ORX43867.1 - 0.001 19.3 0.0 0.0034 17.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 ORX43867.1 - 0.0011 18.8 0.2 0.0073 16.2 0.0 2.3 3 0 0 3 3 2 1 NTPase AAA_7 PF12775.7 ORX43867.1 - 0.0016 17.9 0.1 0.0097 15.4 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_28 PF13521.6 ORX43867.1 - 0.0033 17.7 0.0 0.0062 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX43867.1 - 0.0064 16.2 0.1 0.016 14.9 0.1 1.8 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX43867.1 - 0.0065 16.2 0.1 0.024 14.4 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_3 PF07726.11 ORX43867.1 - 0.0066 16.3 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 ORX43867.1 - 0.0071 15.6 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain Sigma54_activat PF00158.26 ORX43867.1 - 0.0075 16.0 0.1 0.2 11.3 0.0 2.7 3 1 0 3 3 3 1 Sigma-54 interaction domain NACHT PF05729.12 ORX43867.1 - 0.0076 16.2 0.1 0.071 13.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 ORX43867.1 - 0.0076 15.6 0.0 0.017 14.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 ORX43867.1 - 0.01 15.3 0.0 0.57 9.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 ORX43867.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX43867.1 - 0.012 15.2 1.5 0.035 13.7 0.3 2.3 2 1 1 3 3 3 0 AAA domain ATPase PF06745.13 ORX43867.1 - 0.019 14.3 0.1 0.5 9.7 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 ORX43867.1 - 0.031 14.1 0.1 0.079 12.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX43867.1 - 0.037 14.4 0.1 0.11 12.9 0.1 1.8 2 0 0 2 2 1 0 AAA domain Bac_DnaA PF00308.18 ORX43867.1 - 0.055 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein ABC_tran PF00005.27 ORX43867.1 - 0.078 13.5 0.1 0.26 11.8 0.0 2.1 2 2 0 2 2 2 0 ABC transporter SPACA9 PF15120.6 ORX43867.1 - 0.08 12.7 0.3 7.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Sperm acrosome-associated protein 9 ATPase_2 PF01637.18 ORX43867.1 - 0.1 12.5 0.8 0.75 9.7 0.1 2.5 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ORX43867.1 - 0.11 11.7 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Parvo_NS1 PF01057.17 ORX43867.1 - 0.13 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_29 PF13555.6 ORX43867.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4972 PF16342.5 ORX43867.1 - 0.44 10.2 4.0 1.4 8.6 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4972) AAA_23 PF13476.6 ORX43867.1 - 2.5 8.6 0.0 2.5 8.6 0.0 2.4 2 1 0 2 2 1 0 AAA domain Ran-binding PF05508.11 ORX43868.1 - 8.6e-43 146.5 2.8 6.5e-42 143.6 2.8 2.3 1 1 0 1 1 1 1 RanGTP-binding protein HrpF PF06266.12 ORX43868.1 - 0.011 16.0 0.4 0.89 9.9 0.0 2.8 2 0 0 2 2 2 0 HrpF protein Alpha-amylase_C PF02806.18 ORX43875.1 - 2.4e-28 98.4 0.0 7e-28 97.0 0.0 1.8 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 ORX43875.1 - 1.2e-17 64.0 0.1 2.8e-17 62.8 0.1 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 ORX43875.1 - 2.1e-13 50.6 0.0 5.6e-09 36.0 0.0 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Lon_C PF05362.13 ORX43877.1 - 3.5e-70 235.7 0.0 5.9e-70 235.0 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 ORX43877.1 - 3.5e-23 82.5 0.0 8.4e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX43877.1 - 8.6e-08 32.3 0.0 2.1e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 ORX43877.1 - 5e-07 29.6 0.0 1.1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_3 PF07726.11 ORX43877.1 - 3e-06 27.1 0.0 4.8e-05 23.2 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 ORX43877.1 - 2.8e-05 24.3 0.0 7.8e-05 22.8 0.0 1.7 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX43877.1 - 0.00033 21.1 1.0 0.0015 19.0 0.0 2.5 3 0 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 ORX43877.1 - 0.00034 20.4 0.0 0.0018 18.0 0.0 2.2 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 ORX43877.1 - 0.00047 19.2 0.0 0.00081 18.4 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 ORX43877.1 - 0.00086 19.6 1.0 0.032 14.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX43877.1 - 0.0015 18.4 0.0 0.0045 16.9 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase ClpB_D2-small PF10431.9 ORX43877.1 - 0.0048 16.9 0.0 0.03 14.4 0.0 2.4 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein RNA_helicase PF00910.22 ORX43877.1 - 0.0064 16.9 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 RNA helicase IstB_IS21 PF01695.17 ORX43877.1 - 0.0077 16.0 0.1 0.039 13.7 0.0 2.2 3 0 0 3 3 3 1 IstB-like ATP binding protein LON_substr_bdg PF02190.16 ORX43877.1 - 0.011 15.6 0.4 0.032 14.1 0.0 1.9 2 0 0 2 2 2 0 ATP-dependent protease La (LON) substrate-binding domain AAA_18 PF13238.6 ORX43877.1 - 0.012 16.2 0.0 0.036 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX43877.1 - 0.019 15.0 0.0 0.054 13.5 0.0 1.9 2 0 0 2 2 1 0 AAA domain NB-ARC PF00931.22 ORX43877.1 - 0.034 13.3 0.0 0.065 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 ORX43877.1 - 0.062 13.5 1.2 0.15 12.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX43877.1 - 0.073 13.0 0.2 0.88 9.5 0.0 2.8 3 0 0 3 3 3 0 NACHT domain MMR_HSR1 PF01926.23 ORX43877.1 - 0.12 12.4 0.1 2.2 8.4 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase SKI PF01202.22 ORX43877.1 - 0.32 11.1 1.9 0.37 10.9 0.1 1.9 2 0 0 2 2 2 0 Shikimate kinase FUSC PF04632.12 ORX43877.1 - 0.64 8.5 9.2 0.99 7.9 9.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family ABC_tran PF00005.27 ORX43877.1 - 0.66 10.5 2.4 1.5 9.3 0.0 2.4 2 1 0 2 2 2 0 ABC transporter AAA_23 PF13476.6 ORX43877.1 - 3.4 8.1 5.8 2.8 8.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain ETC_C1_NDUFA4 PF04800.12 ORX43879.1 - 1.1e-35 121.8 1.3 1.2e-35 121.6 1.3 1.0 1 0 0 1 1 1 1 ETC complex I subunit conserved region TRAPPC-Trs85 PF12739.7 ORX43881.1 - 1.3e-116 389.9 0.0 2.8e-116 388.8 0.0 1.6 2 0 0 2 2 2 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TRAPPC9-Trs120 PF08626.11 ORX43881.1 - 0.013 12.9 0.0 0.019 12.4 0.0 1.1 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Med15_fungi PF05397.12 ORX43882.1 - 1.3e-32 112.4 2.5 1.3e-32 112.4 2.5 7.6 7 2 2 9 9 9 1 Mediator complex subunit 15 ABC2_membrane_2 PF12679.7 ORX43882.1 - 1.8 7.8 19.8 2.3 7.4 4.6 3.7 3 0 0 3 3 3 0 ABC-2 family transporter protein MAP65_ASE1 PF03999.12 ORX43883.1 - 6.4e-67 226.6 32.4 8.8e-67 226.2 32.4 1.1 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) DASH_Dam1 PF08653.10 ORX43883.1 - 0.0043 16.8 0.8 0.037 13.8 0.0 2.8 3 0 0 3 3 3 1 DASH complex subunit Dam1 Spore_III_AB PF09548.10 ORX43883.1 - 5.4 7.1 13.4 12 5.9 11.0 2.7 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Cyt-b5 PF00173.28 ORX43884.1 - 2.4e-22 78.9 0.0 2.9e-22 78.6 0.0 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Fer4_2 PF12797.7 ORX43991.1 - 0.054 13.6 0.5 0.12 12.6 0.5 1.5 1 0 0 1 1 1 0 4Fe-4S binding domain Lipase_GDSL PF00657.22 ORX43993.1 - 6.3e-14 52.4 0.1 7.7e-14 52.1 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX43993.1 - 1.7e-07 31.9 0.1 2.1e-07 31.5 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family PAT1 PF09770.9 ORX43994.1 - 9.6e-136 454.3 38.7 3.7e-112 376.2 14.8 2.7 1 1 1 2 2 2 2 Topoisomerase II-associated protein PAT1 DUF3520 PF12034.8 ORX43994.1 - 0.057 13.6 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3520) PQ-loop PF04193.14 ORX43995.1 - 5.5e-41 138.1 14.1 9.2e-21 73.4 1.9 2.9 3 0 0 3 3 3 2 PQ loop repeat MtN3_slv PF03083.16 ORX43995.1 - 0.0031 17.5 3.9 0.018 15.1 0.6 2.6 2 1 0 2 2 2 1 Sugar efflux transporter for intercellular exchange Mt_ATP-synt_D PF05873.12 ORX43996.1 - 1.1e-23 83.9 4.4 1.4e-23 83.5 4.4 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Prominin PF05478.11 ORX43996.1 - 0.00021 19.5 3.3 0.00025 19.2 3.3 1.0 1 0 0 1 1 1 1 Prominin DUF327 PF03885.13 ORX43996.1 - 0.0015 18.5 1.4 0.048 13.6 1.4 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF327) Baculo_PEP_C PF04513.12 ORX43996.1 - 0.021 14.9 3.0 0.034 14.2 3.0 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1870 PF08965.10 ORX43996.1 - 0.024 14.7 0.8 0.16 12.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1870) DUF4407 PF14362.6 ORX43996.1 - 0.05 13.0 4.1 0.056 12.8 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WXG100 PF06013.12 ORX43996.1 - 0.057 13.7 1.6 9.6 6.5 0.6 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG RPW8 PF05659.11 ORX43996.1 - 0.071 12.8 0.8 0.31 10.7 0.2 2.1 2 1 1 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Pilus_CpaD PF09476.10 ORX43996.1 - 0.076 12.7 1.0 1.2 8.8 0.1 2.1 1 1 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) FlaC_arch PF05377.11 ORX43996.1 - 0.076 13.4 1.2 9.1 6.8 0.2 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 ORX43996.1 - 0.098 13.0 3.4 0.44 10.9 1.0 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Flagellin_N PF00669.20 ORX43996.1 - 0.48 10.5 5.0 0.27 11.3 2.3 1.9 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region DUF2730 PF10805.8 ORX43996.1 - 0.53 10.4 3.6 6.5 6.9 0.7 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) HIP1_clath_bdg PF16515.5 ORX43996.1 - 1.9 9.2 7.7 11 6.7 1.4 2.9 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_MLP1_2 PF07926.12 ORX43996.1 - 2.2 8.4 7.9 5.5 7.1 0.8 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein SKG6 PF08693.10 ORX43998.1 - 0.00055 19.3 0.5 0.0014 18.0 0.5 1.6 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 ORX43998.1 - 0.047 13.5 0.1 0.098 12.4 0.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 EphA2_TM PF14575.6 ORX43998.1 - 0.077 13.9 0.0 0.13 13.1 0.0 1.4 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain NICE-1 PF15845.5 ORX43998.1 - 0.11 13.3 0.1 0.11 13.3 0.1 2.6 3 1 0 3 3 3 0 Cysteine-rich C-terminal 1 family Amnionless PF14828.6 ORX43998.1 - 0.19 10.5 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless PRCC PF10253.9 ORX43998.1 - 1.4 9.7 10.8 0.064 14.0 0.6 2.1 1 1 1 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Mito_carr PF00153.27 ORX43999.1 - 8.1e-62 205.2 0.1 2.7e-21 75.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein RabGAP-TBC PF00566.18 ORX44000.1 - 5.4e-27 94.8 0.6 1.1e-16 61.1 0.0 2.2 1 1 1 2 2 2 2 Rab-GTPase-TBC domain Pox_A_type_inc PF04508.12 ORX44000.1 - 0.08 12.8 0.3 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Cut8 PF08559.10 ORX44001.1 - 3.1e-09 36.8 2.0 3.8e-09 36.5 2.0 1.2 1 1 0 1 1 1 1 Cut8, nuclear proteasome tether protein MMM1 PF10296.9 ORX44003.1 - 1.8e-05 24.0 0.3 0.00019 20.6 0.0 2.6 3 0 0 3 3 3 1 Maintenance of mitochondrial morphology protein 1 Stimulus_sens_1 PF13756.6 ORX44003.1 - 0.91 10.1 4.3 0.85 10.2 0.5 2.9 3 0 0 3 3 3 0 Stimulus-sensing domain Ribosomal_L31e PF01198.19 ORX44004.1 - 3.9e-37 126.3 1.9 4.9e-37 126.0 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e BAR_3 PF16746.5 ORX44005.1 - 2.3e-54 184.7 9.8 3.9e-54 183.9 9.8 1.3 1 0 0 1 1 1 1 BAR domain of APPL family ArfGap PF01412.18 ORX44005.1 - 2.9e-39 133.7 0.4 7.1e-39 132.5 0.1 1.9 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 ORX44005.1 - 2e-17 63.5 7.4 2e-10 41.1 0.8 2.6 2 1 1 3 3 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX44005.1 - 4.1e-14 52.8 3.5 4.1e-09 36.8 0.3 3.1 1 1 2 3 3 3 3 Ankyrin repeats (many copies) PH PF00169.29 ORX44005.1 - 6.4e-12 45.9 0.0 1.8e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.6 ORX44005.1 - 2.2e-10 39.8 0.0 0.0088 16.5 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat BAR PF03114.18 ORX44005.1 - 3.9e-10 39.8 8.1 9.8e-10 38.5 8.1 1.7 1 1 0 1 1 1 1 BAR domain Ank_5 PF13857.6 ORX44005.1 - 4.9e-09 36.3 0.7 2.8e-08 33.9 0.4 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ORX44005.1 - 4.5e-07 30.0 0.2 0.21 12.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat DHC_N2 PF08393.13 ORX44005.1 - 0.018 14.2 2.8 0.042 13.0 0.6 2.4 2 1 0 3 3 3 0 Dynein heavy chain, N-terminal region 2 Arfaptin PF06456.13 ORX44005.1 - 0.053 13.1 4.5 0.17 11.4 4.5 1.9 1 1 0 1 1 1 0 Arfaptin-like domain La PF05383.17 ORX44006.1 - 1.5e-23 82.6 0.1 2.6e-23 81.8 0.1 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ORX44006.1 - 1.9e-06 27.6 0.0 3.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GATA PF00320.27 ORX44007.1 - 3.8e-08 32.8 3.3 9.5e-08 31.5 3.3 1.7 1 0 0 1 1 1 1 GATA zinc finger DUF2362 PF10154.9 ORX44007.1 - 0.056 12.4 3.7 0.053 12.5 1.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2362) Pex14_N PF04695.13 ORX44007.1 - 7.2 7.2 11.4 19 5.9 11.4 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L18A PF01775.17 ORX44008.1 - 3.4e-53 178.9 0.2 4.6e-53 178.4 0.2 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Lipoprotein_9 PF03180.14 ORX44008.1 - 0.14 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 NLPA lipoprotein SR-25 PF10500.9 ORX44009.1 - 0.88 9.1 10.1 1.5 8.4 10.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Methyltransf_11 PF08241.12 ORX44010.1 - 7e-14 52.2 0.0 1.2e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX44010.1 - 8.3e-14 52.1 0.0 1.5e-13 51.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX44010.1 - 1e-10 41.6 0.0 5.8e-10 39.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX44010.1 - 2.3e-09 37.3 0.0 3.6e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX44010.1 - 9.9e-08 31.5 0.0 1.4e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 ORX44010.1 - 5.3e-07 29.2 0.0 1.5e-06 27.7 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX44010.1 - 1.2e-06 29.2 0.0 3.6e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 ORX44010.1 - 6.4e-06 25.0 0.1 2.1e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_4 PF02390.17 ORX44010.1 - 0.00042 19.8 0.0 0.019 14.4 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.15 ORX44010.1 - 0.001 19.0 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 ORX44010.1 - 0.032 13.8 0.0 0.4 10.2 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase small domain CheR PF01739.18 ORX44010.1 - 0.053 13.0 0.0 0.088 12.3 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltr_RsmB-F PF01189.17 ORX44011.1 - 2.2e-78 262.5 0.0 4.1e-78 261.6 0.0 1.5 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ORX44011.1 - 1.1e-06 29.1 0.0 2.9e-06 27.7 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF Met_10 PF02475.16 ORX44011.1 - 1e-05 25.4 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_31 PF13847.6 ORX44011.1 - 0.00079 19.3 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX44011.1 - 0.011 16.4 0.0 0.042 14.6 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain DUF2431 PF10354.9 ORX44011.1 - 0.041 14.2 0.0 0.07 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) FtsJ PF01728.19 ORX44011.1 - 0.056 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 ORX44011.1 - 0.083 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CUE PF02845.16 ORX44012.1 - 4.5e-10 39.0 0.0 8.2e-10 38.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain GLTP PF08718.11 ORX44013.1 - 6.6e-32 110.8 0.5 2.6e-30 105.7 0.5 2.2 1 1 0 1 1 1 1 Glycolipid transfer protein (GLTP) Peptidase_S28 PF05577.12 ORX44014.1 - 9.7e-48 163.0 0.0 1.1e-47 162.8 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 ORX44014.1 - 1.9e-05 23.5 0.2 2.6e-05 23.1 0.2 1.1 1 0 0 1 1 1 1 PS-10 peptidase S37 Peptidase_S9 PF00326.21 ORX44014.1 - 0.0032 17.0 0.0 0.0044 16.5 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ORX44014.1 - 0.025 14.2 0.0 0.044 13.4 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S28 PF05577.12 ORX44015.1 - 1.6e-13 50.2 3.0 1.7e-13 50.2 3.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 HMG_CoA_synt_N PF01154.17 ORX44015.1 - 0.07 13.0 0.0 0.073 12.9 0.0 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal Ribosomal_S19 PF00203.21 ORX44016.1 - 3.4e-34 116.6 0.3 4.5e-34 116.2 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 FliH PF02108.16 ORX44016.1 - 0.058 13.5 0.0 0.066 13.3 0.0 1.1 1 0 0 1 1 1 0 Flagellar assembly protein FliH Cmc1 PF08583.10 ORX44017.1 - 1.6e-14 53.7 9.3 2e-14 53.3 9.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like NFACT-R_1 PF05670.13 ORX44017.1 - 0.057 14.1 0.4 0.076 13.7 0.4 1.3 1 1 0 1 1 1 0 NFACT protein RNA binding domain RNA_pol_Rpb1_4 PF05000.17 ORX44017.1 - 0.13 12.2 0.1 0.18 11.8 0.0 1.3 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 4 COX17 PF05051.13 ORX44017.1 - 0.91 9.9 5.9 0.45 10.9 2.2 2.0 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) Steroid_dh PF02544.16 ORX44018.1 - 4.4e-34 117.6 2.6 7e-34 117.0 2.6 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ORX44018.1 - 8.6e-05 22.2 0.8 0.00014 21.5 0.3 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ORX44018.1 - 0.14 12.6 0.4 0.14 12.6 0.4 2.7 2 1 1 3 3 3 0 Phospholipid methyltransferase DUF1035 PF06281.12 ORX44018.1 - 0.93 9.5 5.1 3 7.9 2.8 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1035) Myb_DNA-binding PF00249.31 ORX44019.1 - 5e-27 93.8 5.3 1.4e-08 34.8 0.2 5.7 6 0 0 6 6 6 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX44019.1 - 2.6e-24 85.2 4.9 8.1e-08 32.4 0.1 4.9 2 2 3 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX44019.1 - 8.9e-05 22.3 2.8 0.79 9.7 0.1 3.9 3 1 1 4 4 4 2 Myb DNA-binding like SLIDE PF09111.10 ORX44019.1 - 0.0039 17.2 0.3 1.2 9.2 0.0 3.6 2 2 1 3 3 3 1 SLIDE Myb_DNA-bind_4 PF13837.6 ORX44019.1 - 0.0085 16.5 3.1 12 6.3 0.0 3.9 3 0 0 3 3 3 2 Myb/SANT-like DNA-binding domain SANT_DAMP1_like PF16282.5 ORX44019.1 - 0.012 15.8 0.8 4.6 7.5 0.1 3.0 2 1 0 2 2 2 0 SANT/Myb-like domain of DAMP1 Ntox50 PF15542.6 ORX44019.1 - 0.039 14.8 0.1 37 5.2 0.0 3.3 3 0 0 3 3 3 0 Bacterial toxin 50 F-box-like PF12937.7 ORX44020.1 - 3.6e-12 46.0 2.0 7.5e-12 45.0 0.4 2.4 2 0 0 2 2 2 1 F-box-like LRR_6 PF13516.6 ORX44020.1 - 2.1e-09 36.7 10.4 0.061 13.4 0.0 8.6 9 0 0 9 9 9 2 Leucine Rich repeat F-box PF00646.33 ORX44020.1 - 2.9e-09 36.6 0.6 1e-07 31.6 0.1 2.9 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 ORX44020.1 - 7.2e-07 29.4 7.2 0.27 11.7 0.1 6.9 6 1 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX44020.1 - 0.056 14.0 15.0 29 5.7 0.3 7.0 8 1 0 8 8 8 0 Leucine Rich Repeat DnaJ PF00226.31 ORX44021.1 - 1.3e-15 57.3 0.2 2.4e-15 56.4 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain HflK_N PF12221.8 ORX44021.1 - 8.1 6.5 6.7 47 4.1 3.8 2.3 2 0 0 2 2 2 0 Bacterial membrane protein N terminal Choline_kinase PF01633.20 ORX44022.1 - 6.3e-58 195.9 0.0 1.2e-57 195.0 0.0 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ORX44022.1 - 4e-13 49.8 0.0 5.7e-13 49.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX44022.1 - 2.3e-06 27.2 0.2 0.00052 19.4 0.1 2.2 2 0 0 2 2 2 2 Ecdysteroid kinase Fructosamin_kin PF03881.14 ORX44022.1 - 6.2e-05 22.3 0.0 7.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase DUF1679 PF07914.11 ORX44022.1 - 0.043 12.7 0.0 0.063 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) DPBB_1 PF03330.18 ORX44023.1 - 4.2e-09 36.6 0.1 1.1e-08 35.3 0.1 1.7 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX44023.1 - 8.5e-06 25.6 1.1 1.2e-05 25.1 0.2 1.8 2 0 0 2 2 2 1 Barwin family Cyclin_N PF00134.23 ORX44024.1 - 7.6e-17 61.2 0.6 2.9e-15 56.1 0.4 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 ORX44024.1 - 2.5e-10 40.2 0.1 0.00025 21.0 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_C PF02984.19 ORX44024.1 - 1.4e-05 25.1 2.3 0.007 16.4 0.0 2.7 2 1 0 2 2 2 2 Cyclin, C-terminal domain Peptidase_S10 PF00450.22 ORX44025.1 - 6.5e-112 375.0 0.0 8e-112 374.7 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase PrpR_N PF06506.11 ORX44025.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Propionate catabolism activator Adeno_E3_CR2 PF02439.15 ORX44025.1 - 0.17 11.7 0.3 0.28 11.0 0.3 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 HAP1_N PF04849.13 ORX44026.1 - 2.1e-05 23.9 0.3 2.1e-05 23.9 0.3 2.8 2 1 0 2 2 2 1 HAP1 N-terminal conserved region Tup_N PF08581.10 ORX44026.1 - 0.0023 18.2 4.7 0.0023 18.2 4.7 3.6 3 1 0 3 3 3 1 Tup N-terminal Matrilin_ccoil PF10393.9 ORX44026.1 - 0.03 14.2 0.3 0.13 12.1 0.3 2.1 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin Fib_alpha PF08702.10 ORX44026.1 - 0.065 13.4 18.3 0.14 12.3 4.6 2.7 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Med10 PF09748.9 ORX44026.1 - 0.28 11.2 3.7 0.73 9.8 0.1 2.9 2 1 0 2 2 2 0 Transcription factor subunit Med10 of Mediator complex MGC-24 PF05283.11 ORX44026.1 - 3.6 8.1 6.2 1.9 8.9 2.3 2.5 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Fmp27_WPPW PF10359.9 ORX44026.1 - 5.2 5.8 26.9 0.016 14.1 7.6 2.8 1 1 2 3 3 3 0 RNA pol II promoter Fmp27 protein domain FUSC PF04632.12 ORX44026.1 - 5.8 5.3 14.4 0.11 11.0 6.3 2.2 2 1 0 2 2 2 0 Fusaric acid resistance protein family DUF3450 PF11932.8 ORX44026.1 - 6.1 6.1 15.7 0.23 10.7 4.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Bap31_Bap29_C PF18035.1 ORX44026.1 - 7.6 6.6 11.8 2.5 8.2 1.7 4.4 4 1 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain NAD_binding_1 PF00175.21 ORX44027.1 - 4.6e-31 107.7 0.0 7.3e-31 107.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX44027.1 - 2.2e-13 50.4 0.0 9.8e-13 48.3 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ORX44027.1 - 1.6e-08 34.8 0.0 1.8e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain ECH_1 PF00378.20 ORX44028.1 - 9e-23 80.9 0.0 1.1e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX44028.1 - 2.2e-05 24.1 0.0 2.6e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase CRM1_C PF08767.11 ORX44028.1 - 0.16 11.1 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 CRM1 C terminal Zn_clus PF00172.18 ORX44029.1 - 1.2e-12 47.7 9.5 1.2e-12 47.7 9.5 1.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ADH_zinc_N PF00107.26 ORX44030.1 - 6.2e-09 35.9 0.1 3.5e-08 33.5 0.0 2.2 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX44030.1 - 0.01 16.9 0.1 0.033 15.2 0.0 1.9 2 1 0 2 2 2 0 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX44030.1 - 0.016 14.5 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 ORX44030.1 - 0.081 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FAO_M PF16350.5 ORX44031.1 - 0.039 14.3 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain RRM_1 PF00076.22 ORX44032.1 - 8.8e-14 51.1 0.2 2.8e-06 27.0 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Redoxin PF08534.10 ORX44034.1 - 2.4e-30 105.2 0.0 2.7e-30 105.0 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ORX44034.1 - 6.1e-06 26.2 0.0 7.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family PI3_PI4_kinase PF00454.27 ORX44035.1 - 1.8e-40 139.3 0.0 2.3e-38 132.5 0.0 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ORX44035.1 - 1.1e-22 80.4 0.1 5.4e-22 78.1 0.0 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ORX44035.1 - 0.045 13.1 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) PI3_PI4_kinase PF00454.27 ORX44036.1 - 3.7e-08 33.5 0.0 4.5e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase zf-A20 PF01754.16 ORX44065.1 - 3.2e-11 43.0 8.7 3.2e-11 43.0 8.7 1.9 2 0 0 2 2 2 1 A20-like zinc finger zf-AN1 PF01428.16 ORX44065.1 - 7.2e-07 29.3 8.0 7.2e-07 29.3 8.0 2.1 2 0 0 2 2 2 1 AN1-like Zinc finger Med3 PF11593.8 ORX44065.1 - 7.6 5.6 10.7 9.6 5.3 10.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal SOG2 PF10428.9 ORX44065.1 - 7.7 5.6 8.6 9.3 5.3 8.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein R3H PF01424.22 ORX44066.1 - 8.2e-13 48.1 0.0 1.4e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 ORX44066.1 - 2.3e-11 43.5 54.9 5.7e-06 26.3 13.1 14.9 15 2 1 16 16 16 6 NF-X1 type zinc finger Cmc1 PF08583.10 ORX44067.1 - 2.1e-13 50.1 4.3 2.7e-13 49.7 4.3 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Pro_CA PF00484.19 ORX44067.1 - 0.1 12.9 0.1 0.11 12.7 0.1 1.1 1 0 0 1 1 1 0 Carbonic anhydrase Ribosomal_L30_N PF08079.12 ORX44067.1 - 0.18 12.1 5.6 0.3 11.4 5.6 1.3 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain COX17 PF05051.13 ORX44067.1 - 9.1 6.7 8.4 24 5.4 0.1 2.8 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) RRM_1 PF00076.22 ORX44068.1 - 1.3e-31 108.2 0.0 1.9e-19 69.2 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX44068.1 - 2.9e-07 30.6 0.1 7.1e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_8 PF11835.8 ORX44068.1 - 0.0088 16.2 0.0 0.2 11.9 0.0 2.4 2 0 0 2 2 2 1 RRM-like domain PHM7_cyt PF14703.6 ORX44068.1 - 0.55 10.4 2.4 1.5 9.0 0.1 2.8 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter Pkinase PF00069.25 ORX44069.1 - 2.4e-66 223.8 0.0 3.2e-66 223.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF3543 PF12063.8 ORX44069.1 - 3e-53 180.8 0.2 6.2e-53 179.7 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase_Tyr PF07714.17 ORX44069.1 - 1.2e-39 136.1 0.0 1.8e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 ORX44069.1 - 0.009 16.2 0.0 0.025 14.8 0.0 1.7 1 0 0 1 1 1 1 ABC1 family Pkinase_fungal PF17667.1 ORX44069.1 - 0.01 14.7 0.0 0.025 13.4 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase SelP_N PF04592.14 ORX44069.1 - 3.7 6.9 10.8 11 5.4 10.8 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region P5CR_dimer PF14748.6 ORX44071.1 - 4.7e-36 123.2 3.3 6.4e-36 122.7 3.3 1.2 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation Arf PF00025.21 ORX44072.1 - 8.6e-76 253.3 0.1 9.6e-76 253.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX44072.1 - 2.3e-15 56.8 0.1 3.1e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX44072.1 - 4.1e-14 52.5 0.0 4.7e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ORX44072.1 - 6.7e-12 45.2 0.0 8.6e-12 44.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ORX44072.1 - 3.6e-11 42.8 1.6 5.7e-07 29.0 0.2 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ORX44072.1 - 5.2e-11 42.4 0.0 6.5e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX44072.1 - 2.9e-05 24.1 0.0 3.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ORX44072.1 - 0.0017 17.7 0.2 0.0019 17.5 0.2 1.3 1 1 0 1 1 1 1 6-phosphofructo-2-kinase DUF2754 PF10953.8 ORX44072.1 - 0.055 13.7 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2754) DLIC PF05783.11 ORX44072.1 - 0.068 12.0 0.2 0.097 11.5 0.1 1.4 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_33 PF13671.6 ORX44072.1 - 0.12 12.5 0.1 0.27 11.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain Sdh5 PF03937.16 ORX44073.1 - 1.5e-26 92.1 1.4 2e-26 91.7 1.4 1.2 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase CBS PF00571.28 ORX44074.1 - 7.2e-30 103.2 7.7 6.1e-08 33.0 0.0 5.2 5 1 0 5 5 5 4 CBS domain PB1 PF00564.24 ORX44074.1 - 1.2e-09 38.0 0.9 4.5e-09 36.1 0.9 2.0 1 1 0 1 1 1 1 PB1 domain MOSP_N PF02707.16 ORX44075.1 - 0.1 12.3 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Major Outer Sheath Protein N-terminal region Forkhead PF00250.18 ORX44076.1 - 8.3e-24 83.7 0.2 1.6e-10 41.1 0.0 2.2 2 0 0 2 2 2 2 Forkhead domain tRNA-synt_1b PF00579.25 ORX44078.1 - 8e-23 81.2 0.0 2.2e-22 79.7 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) SF3A2 PF16835.5 ORX44081.1 - 5.3e-40 135.7 0.3 8.5e-40 135.0 0.3 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 ORX44081.1 - 1.4e-06 28.5 2.0 1.4e-06 28.5 2.0 2.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 ORX44081.1 - 8.4e-06 25.7 0.7 1.4e-05 25.0 0.7 1.3 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 ORX44081.1 - 0.043 13.4 1.5 0.067 12.8 1.5 1.3 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like zf-C2H2_jaz PF12171.8 ORX44081.1 - 6.5 7.2 8.0 18 5.8 4.9 3.1 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Aminotran_3 PF00202.21 ORX44082.1 - 3e-113 378.5 0.0 3.7e-113 378.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III B12-binding PF02310.19 ORX44082.1 - 0.0017 18.4 0.0 0.0039 17.2 0.0 1.6 1 0 0 1 1 1 1 B12 binding domain DUF746 PF05344.11 ORX44082.1 - 0.14 12.1 0.1 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF746) Palm_thioest PF02089.15 ORX44084.1 - 8.3e-87 291.0 0.0 9.6e-87 290.8 0.0 1.0 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 ORX44084.1 - 0.052 14.1 0.0 0.071 13.7 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 ORX44084.1 - 0.064 12.8 0.0 0.14 11.7 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) FSH1 PF03959.13 ORX44084.1 - 0.077 12.6 0.0 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ORX44084.1 - 0.098 12.3 0.0 0.58 9.8 0.0 2.2 3 0 0 3 3 3 0 alpha/beta hydrolase fold Erf4 PF10256.9 ORX44085.1 - 0.029 14.5 0.1 0.037 14.1 0.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family GAT PF03127.14 ORX44085.1 - 0.031 14.6 0.8 0.18 12.1 0.4 1.9 1 1 1 2 2 2 0 GAT domain THOC7 PF05615.13 ORX44085.1 - 0.085 13.1 0.4 0.1 12.9 0.4 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 Alpha-mann_mid PF09261.11 ORX44085.1 - 0.088 13.0 0.4 0.51 10.5 0.4 1.9 1 1 0 1 1 1 0 Alpha mannosidase middle domain UPF0240 PF06784.11 ORX44085.1 - 0.1 12.7 0.1 0.12 12.5 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) AstE_AspA PF04952.14 ORX44087.1 - 4.4e-32 111.3 0.0 8.3e-32 110.4 0.0 1.4 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family HutD PF05962.11 ORX44087.1 - 3.5e-05 23.9 0.0 0.031 14.3 0.0 2.4 1 1 1 2 2 2 2 HutD Metallophos PF00149.28 ORX44088.1 - 0.0019 18.7 0.0 0.0042 17.6 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase HMG_box PF00505.19 ORX44089.1 - 1.1e-36 125.0 5.5 9.4e-18 64.4 2.0 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX44089.1 - 7.2e-28 97.0 2.1 2.6e-13 50.3 0.6 2.4 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.12 ORX44089.1 - 0.00099 19.0 0.4 0.04 13.9 0.2 3.1 3 0 0 3 3 3 1 CHDNT (NUC034) domain HMG_box_5 PF14887.6 ORX44089.1 - 0.0063 16.5 3.0 0.0095 15.9 0.4 2.3 2 0 0 2 2 2 1 HMG (high mobility group) box 5 Protamine_like PF06382.11 ORX44089.1 - 0.053 13.7 0.7 1.9 8.7 0.1 2.4 2 0 0 2 2 2 0 Protamine and protamine like Imm58 PF15581.6 ORX44089.1 - 0.082 13.0 0.2 1.2 9.3 0.0 2.1 2 0 0 2 2 2 0 Immunity protein 58 ACOX PF01756.19 ORX44090.1 - 1.1e-48 165.2 0.1 2.2e-48 164.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX44090.1 - 9.6e-28 97.2 0.4 1.6e-27 96.5 0.4 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX44090.1 - 3.1e-14 52.9 0.0 1.5e-13 50.7 0.0 2.1 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ORX44090.1 - 0.02 15.1 2.9 0.023 14.9 0.0 2.5 3 0 0 3 3 3 0 Acyl-CoA dehydrogenase, C-terminal domain PhoLip_ATPase_C PF16212.5 ORX44091.1 - 5.8e-73 245.7 30.8 5.8e-73 245.7 30.8 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX44091.1 - 3e-23 81.3 0.3 8.3e-23 79.9 0.3 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX44091.1 - 5.2e-13 48.9 0.0 2.5e-11 43.5 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX44091.1 - 2.1e-10 41.3 0.4 0.0095 16.2 0.0 3.4 2 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX44091.1 - 0.00095 18.7 0.8 0.00095 18.7 0.8 2.9 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX44091.1 - 0.0069 16.1 0.2 0.028 14.2 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase GSH-S_ATP PF02955.16 ORX44091.1 - 0.17 11.2 0.0 0.63 9.4 0.0 1.8 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, ATP-grasp domain bZIP_1 PF00170.21 ORX44092.1 - 2.7e-10 40.2 8.9 2.7e-10 40.2 8.9 2.0 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ORX44092.1 - 8.8e-07 28.9 11.1 8.8e-07 28.9 11.1 2.6 2 1 1 3 3 3 1 Basic region leucine zipper DUF812 PF05667.11 ORX44092.1 - 0.098 11.5 10.7 0.14 11.0 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF16 PF01519.16 ORX44092.1 - 0.2 12.2 4.0 0.39 11.2 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 XhlA PF10779.9 ORX44092.1 - 0.84 9.9 2.2 1.6 9.0 1.6 1.7 1 1 0 1 1 1 0 Haemolysin XhlA DUF1664 PF07889.12 ORX44092.1 - 2.4 8.2 4.4 5.8 7.0 4.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) bZIP_Maf PF03131.17 ORX44092.1 - 2.9 8.5 16.3 0.28 11.8 10.8 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor PRMT5 PF05185.16 ORX44093.1 - 1.1e-71 240.2 0.0 1.8e-71 239.5 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_TIM PF17285.2 ORX44093.1 - 6.5e-57 192.7 0.1 1.1e-56 191.9 0.1 1.3 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5_C PF17286.2 ORX44093.1 - 1.3e-55 188.0 1.9 2.1e-55 187.3 1.9 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain RRM_1 PF00076.22 ORX44094.1 - 1.5e-57 191.3 2.0 1.5e-18 66.4 0.0 6.5 4 2 1 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX44094.1 - 3.3e-06 26.7 0.0 0.036 13.7 0.0 4.1 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX44094.1 - 2.7e-05 24.2 0.0 0.16 12.1 0.0 3.9 4 0 0 4 4 4 2 RNA recognition motif RRM_Rrp7 PF17799.1 ORX44094.1 - 0.00014 21.7 0.3 0.97 9.2 0.0 4.9 4 1 1 5 5 5 1 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 ORX44094.1 - 0.029 14.4 12.5 1 9.5 0.0 5.2 5 0 0 5 5 5 0 RNA binding motif PI3K_1B_p101 PF10486.9 ORX44094.1 - 4.9 4.8 15.2 7.6 4.2 15.2 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4381 PF14316.6 ORX44095.1 - 0.022 15.0 0.1 0.063 13.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF4758 PF15950.5 ORX44095.1 - 2.9 8.3 6.4 4.6 7.6 1.2 2.8 2 0 0 2 2 2 0 Putative sperm flagellar membrane protein DUF676 PF05057.14 ORX44096.1 - 2.9e-39 134.8 0.0 4.8e-39 134.1 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ORX44096.1 - 0.00018 21.5 0.0 0.00031 20.7 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 ORX44096.1 - 0.01 15.7 0.0 0.047 13.5 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) UPF0767 PF15990.5 ORX44096.1 - 0.019 15.1 0.0 0.085 13.0 0.0 2.0 2 0 0 2 2 2 0 UPF0767 family SH3_9 PF14604.6 ORX44098.1 - 1.8e-11 43.7 0.0 2.4e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX44098.1 - 1.1e-05 24.9 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX44098.1 - 0.001 18.7 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain RRM_1 PF00076.22 ORX44099.1 - 5.2e-18 64.6 0.1 7e-18 64.2 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TM2 PF05154.16 ORX44100.1 - 5.4e-15 55.5 6.1 1.2e-14 54.3 6.1 1.5 1 0 0 1 1 1 1 TM2 domain MIT PF04212.18 ORX44101.1 - 2.6e-07 30.6 0.3 2.2e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Sec3_C_2 PF15278.6 ORX44101.1 - 0.07 13.5 1.3 1.2 9.5 0.4 2.4 1 1 0 2 2 2 0 Sec3 exocyst complex subunit BSD PF03909.17 ORX44102.1 - 1.6e-16 60.0 0.2 1.6e-16 60.0 0.2 1.8 2 0 0 2 2 2 1 BSD domain Mce4_CUP1 PF11887.8 ORX44102.1 - 0.083 12.3 1.2 0.23 10.9 1.2 1.7 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative GHMP_kinases_N PF00288.26 ORX44103.1 - 2e-15 56.8 2.3 2e-15 56.8 2.3 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX44103.1 - 3.4e-08 33.7 0.1 9.9e-08 32.2 0.0 1.8 1 1 0 1 1 1 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 ORX44103.1 - 0.0011 18.5 0.0 0.0018 17.8 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature Ribosomal_S10 PF00338.22 ORX44104.1 - 7e-29 99.9 0.5 9.1e-29 99.6 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e DUF2540 PF10802.8 ORX44104.1 - 0.083 13.0 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) Macoilin PF09726.9 ORX44106.1 - 0.0097 14.5 18.0 0.015 13.9 18.0 1.3 1 0 0 1 1 1 1 Macoilin family MARVEL PF01284.23 ORX44107.1 - 1.6e-09 38.0 12.7 2.2e-09 37.5 12.7 1.2 1 0 0 1 1 1 1 Membrane-associating domain DUF1461 PF07314.11 ORX44107.1 - 0.072 13.0 4.9 0.56 10.1 0.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1461) MpPF26 PF07666.11 ORX44107.1 - 0.096 12.8 0.1 0.096 12.8 0.1 2.7 1 1 2 3 3 3 0 M penetrans paralogue family 26 DUF3619 PF12279.8 ORX44107.1 - 0.23 11.8 1.8 16 5.8 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) GWT1 PF06423.12 ORX44107.1 - 0.29 11.2 7.7 2.4 8.3 0.5 2.2 1 1 1 2 2 2 0 GWT1 EphA2_TM PF14575.6 ORX44107.1 - 0.85 10.5 2.7 2.8 8.9 0.0 2.7 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CitMHS PF03600.16 ORX44107.1 - 1.4 8.0 10.2 2.1 7.5 10.2 1.2 1 0 0 1 1 1 0 Citrate transporter 2TM PF13239.6 ORX44107.1 - 4 7.8 13.2 60 4.0 13.2 2.4 1 1 0 1 1 1 0 2TM domain DUF3397 PF11877.8 ORX44107.1 - 6.6 7.0 13.7 3.6 7.8 8.7 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3397) COPI_assoc PF08507.10 ORX44108.1 - 2.3e-16 60.1 11.0 2.9e-16 59.7 11.0 1.1 1 0 0 1 1 1 1 COPI associated protein CBP_BcsG PF11658.8 ORX44108.1 - 1 7.7 4.3 0.45 8.8 0.1 1.9 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsG YfhO PF09586.10 ORX44108.1 - 8.1 4.5 7.8 8.7 4.4 7.8 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO CBF PF03914.17 ORX44109.1 - 6.9e-53 179.2 0.1 6.9e-53 179.2 0.1 3.5 4 0 0 4 4 4 2 CBF/Mak21 family Cnd1 PF12717.7 ORX44109.1 - 0.0053 16.8 0.4 0.0053 16.8 0.4 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 zf-C2H2 PF00096.26 ORX44110.1 - 4.1e-06 27.0 11.6 0.0059 17.0 0.9 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 ORX44110.1 - 8.4e-06 26.0 8.0 0.007 16.5 0.5 2.6 2 1 1 3 3 3 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 ORX44110.1 - 0.00024 21.7 14.5 0.035 14.9 0.5 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf_Hakai PF18408.1 ORX44110.1 - 0.32 10.7 2.5 0.98 9.2 0.1 2.5 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain Ank_2 PF12796.7 ORX44111.1 - 3.1e-25 88.5 0.8 1.2e-11 45.1 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX44111.1 - 5.6e-19 68.3 2.2 7.5e-09 36.0 0.2 4.3 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ORX44111.1 - 1.7e-17 63.0 5.5 3.7e-05 24.0 0.1 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ORX44111.1 - 7.8e-16 56.6 2.2 0.00028 21.1 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ORX44111.1 - 3.6e-15 55.8 6.2 3e-05 24.2 0.2 4.6 1 1 4 5 5 5 3 Ankyrin repeats (many copies) Sec66 PF09802.9 ORX44112.1 - 2.2e-32 112.1 0.1 2.3e-32 112.0 0.1 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 CcmF_C PF16327.5 ORX44113.1 - 0.0029 16.9 5.3 0.0095 15.2 0.3 2.1 2 0 0 2 2 2 2 Cytochrome c-type biogenesis protein CcmF C-terminal EOS1 PF12326.8 ORX44113.1 - 0.06 13.3 0.0 0.06 13.3 0.0 1.9 2 0 0 2 2 2 0 N-glycosylation protein Cupin_8 PF13621.6 ORX44116.1 - 7e-19 68.5 0.2 1.3e-18 67.7 0.2 1.4 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ORX44116.1 - 2.7e-17 63.2 0.0 6.2e-17 62.1 0.0 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase DUF3446 PF11928.8 ORX44116.1 - 0.84 10.0 15.3 0.48 10.8 11.3 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Asp PF00026.23 ORX44117.1 - 1.6e-56 192.0 0.3 1.9e-56 191.8 0.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX44117.1 - 2.5e-08 34.3 0.4 8.9e-06 26.0 0.4 2.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX44117.1 - 0.00096 19.0 0.0 0.0025 17.6 0.0 1.7 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX44117.1 - 0.087 13.4 0.1 14 6.3 0.0 3.6 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Lipoprotein_20 PF13942.6 ORX44117.1 - 0.22 11.4 0.0 2.5 8.0 0.1 2.0 2 0 0 2 2 2 0 YfhG lipoprotein TatD_DNase PF01026.21 ORX44118.1 - 6.3e-36 124.1 0.0 7.5e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase Tubulin-binding PF00418.19 ORX44119.1 - 4e-102 333.8 67.9 7.6e-10 38.6 0.5 11.3 11 0 0 11 11 11 11 Tau and MAP protein, tubulin-binding repeat DUF4218 PF13960.6 ORX44120.1 - 4.9e-05 22.9 0.0 8.7e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) LolA PF03548.15 ORX44120.1 - 0.18 11.5 0.0 1.7 8.3 0.0 2.0 2 0 0 2 2 2 0 Outer membrane lipoprotein carrier protein LolA VATC PF18716.1 ORX44233.1 - 0.0012 18.7 2.1 0.0026 17.6 2.1 1.7 1 0 0 1 1 1 1 Vms1-associating treble clef domain LRR_4 PF12799.7 ORX44235.1 - 2.2e-24 85.1 23.4 4.2e-09 36.5 5.4 5.2 2 2 3 5 5 5 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX44235.1 - 6.2e-23 80.3 19.5 1.2e-10 41.0 10.6 4.1 3 1 0 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 ORX44235.1 - 2.4e-06 27.1 24.6 0.88 9.8 0.1 7.7 8 0 0 8 8 8 4 Leucine Rich repeat LRR_9 PF14580.6 ORX44235.1 - 4.6e-05 23.0 3.3 0.00017 21.1 0.4 2.5 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 ORX44235.1 - 0.00015 21.8 28.8 0.72 10.6 1.9 7.7 5 1 1 6 6 6 3 Leucine Rich Repeat Flavin_Reduct PF01613.18 ORX44236.1 - 5.6e-40 136.9 0.0 7.5e-40 136.5 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain RbpA PF13397.6 ORX44236.1 - 0.16 12.6 0.4 0.33 11.6 0.4 1.4 1 0 0 1 1 1 0 RNA polymerase-binding protein Arrestin_C PF02752.22 ORX44237.1 - 6.7e-13 49.2 0.0 2.2e-11 44.3 0.1 2.5 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX44237.1 - 1.9e-05 24.8 0.0 0.00073 19.6 0.0 2.9 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Rab5ip PF07019.12 ORX44238.1 - 1.3e-19 70.5 4.7 1.6e-19 70.2 4.7 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) Transport_MerF PF11431.8 ORX44238.1 - 0.71 9.8 4.6 11 6.0 0.2 2.4 2 0 0 2 2 2 0 Membrane transport protein MerF Cyclin PF08613.11 ORX44239.1 - 2.3e-09 37.8 0.0 4.2e-09 37.0 0.0 1.4 1 1 0 1 1 1 1 Cyclin Aminotran_1_2 PF00155.21 ORX44240.1 - 1.3e-82 277.9 0.0 1.5e-82 277.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Fibrillarin PF01269.17 ORX44240.1 - 0.066 12.3 0.1 0.12 11.5 0.1 1.4 1 0 0 1 1 1 0 Fibrillarin PIG-H PF10181.9 ORX44241.1 - 6.2e-16 58.0 0.1 7.9e-16 57.7 0.1 1.1 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component TIG PF01833.24 ORX44242.1 - 5.6e-10 39.2 0.1 2.5e-09 37.1 0.0 2.1 2 0 0 2 2 2 1 IPT/TIG domain Ank_2 PF12796.7 ORX44242.1 - 1.3e-07 32.1 0.5 2.7e-07 31.1 0.5 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX44242.1 - 5.6e-05 23.2 1.5 0.035 14.6 0.1 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ORX44242.1 - 0.00023 21.6 0.6 0.0038 17.8 0.2 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ORX44242.1 - 0.00063 20.1 6.4 0.054 14.0 0.5 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX44242.1 - 0.0011 19.2 1.0 0.0025 18.1 0.5 1.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Spt20 PF12090.8 ORX44242.1 - 3.1 7.4 17.6 0.61 9.7 12.2 2.4 2 1 0 2 2 2 0 Spt20 family PTPLA PF04387.14 ORX44243.1 - 8.9e-46 155.6 9.0 1.5e-45 154.9 9.0 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA FGGY_C PF02782.16 ORX44244.1 - 1.7e-51 174.8 0.1 2.5e-51 174.2 0.1 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ORX44244.1 - 2.4e-23 83.0 0.0 9.2e-23 81.1 0.0 2.0 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 ORX44244.1 - 0.00017 21.2 0.0 0.0014 18.1 0.0 2.0 2 0 0 2 2 2 1 BadF/BadG/BcrA/BcrD ATPase family MFS_1 PF07690.16 ORX44245.1 - 7.4e-33 113.9 64.8 2.1e-24 86.1 41.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX44245.1 - 3.3e-08 32.9 6.4 3.3e-08 32.9 6.4 4.1 2 2 1 4 4 4 3 Sugar (and other) transporter Staph_opine_DH PF10100.9 ORX44247.1 - 0.14 10.8 0.0 0.16 10.6 0.0 1.0 1 0 0 1 1 1 0 Staphylopine dehydrogenase DUF572 PF04502.13 ORX44249.1 - 1.7e-71 241.6 12.1 3.5e-70 237.3 12.1 2.0 1 1 0 1 1 1 1 Family of unknown function (DUF572) PNPase PF03726.14 ORX44249.1 - 0.011 16.2 4.5 0.017 15.6 2.2 2.2 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain zf-NADH-PPase PF09297.11 ORX44249.1 - 0.024 14.3 2.2 2.2 8.0 0.2 3.2 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain zf-ACC PF17848.1 ORX44249.1 - 0.032 14.3 2.3 1.4 9.0 0.5 2.5 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain DUF866 PF05907.13 ORX44249.1 - 0.051 13.5 0.2 0.091 12.7 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) TF_Zn_Ribbon PF08271.12 ORX44249.1 - 0.1 12.2 1.5 1.7 8.2 0.1 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding HypA PF01155.19 ORX44249.1 - 0.2 11.7 1.3 0.67 10.0 0.4 2.1 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_4 PF13717.6 ORX44249.1 - 0.23 11.4 2.6 5.5 7.0 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain DUF2175 PF09943.9 ORX44249.1 - 0.34 11.2 2.2 1.5 9.2 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Sorting_nexin PF03700.13 ORX44249.1 - 0.7 10.5 8.5 0.55 10.8 6.8 1.7 1 1 0 1 1 1 0 Sorting nexin, N-terminal domain CpXC PF14353.6 ORX44249.1 - 1 9.4 4.3 12 6.0 0.1 3.0 1 1 1 2 2 2 0 CpXC protein DUF5353 PF17304.2 ORX44250.1 - 0.02 14.6 0.2 0.041 13.6 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5353) Plasmid_stab_B PF10784.9 ORX44250.1 - 0.048 13.5 0.1 0.088 12.6 0.1 1.4 1 0 0 1 1 1 0 Plasmid stability protein GT87 PF09594.10 ORX44251.1 - 0.0034 17.1 1.3 0.0053 16.5 1.3 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 87 HHH_9 PF17674.1 ORX44251.1 - 0.032 15.1 0.0 0.046 14.6 0.0 1.2 1 0 0 1 1 1 0 HHH domain MHYT PF03707.16 ORX44251.1 - 0.12 12.5 0.2 0.12 12.5 0.2 1.9 2 0 0 2 2 2 0 Bacterial signalling protein N terminal repeat IPTL-CTERM PF18203.1 ORX44251.1 - 0.15 12.0 0.8 0.28 11.1 0.8 1.5 1 0 0 1 1 1 0 IPTL-CTERM motif Herpes_UL73 PF03554.13 ORX44251.1 - 6 7.0 7.9 8.3 6.5 0.6 2.4 2 0 0 2 2 2 0 UL73 viral envelope glycoprotein TFIIA_gamma_C PF02751.14 ORX44252.1 - 5.6e-25 87.2 1.6 7.7e-25 86.8 1.6 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 ORX44252.1 - 4.1e-14 52.3 0.0 6.4e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain HA2 PF04408.23 ORX44253.1 - 2.6e-22 79.1 0.4 7.6e-22 77.6 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX44253.1 - 1.1e-17 64.1 0.0 2.5e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ORX44254.1 - 1.3e-05 25.0 0.0 2.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX44254.1 - 1.9e-05 25.0 0.0 4.8e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX44254.1 - 0.0012 18.6 0.0 0.0029 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ORX44254.1 - 0.0019 17.3 0.0 0.0035 16.4 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ORX44254.1 - 0.0037 16.8 0.0 0.01 15.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2075 PF09848.9 ORX44254.1 - 0.0051 16.1 1.2 0.0078 15.5 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ORX44254.1 - 0.0058 17.0 0.1 0.011 16.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX44254.1 - 0.0088 16.6 3.3 0.056 14.0 0.0 2.7 2 1 0 2 2 2 1 ABC transporter Flavi_DEAD PF07652.14 ORX44254.1 - 0.0096 15.9 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.15 ORX44254.1 - 0.02 14.9 0.8 3 7.8 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 ORX44254.1 - 0.051 13.2 0.1 0.085 12.5 0.1 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NB-ARC PF00931.22 ORX44254.1 - 0.053 12.7 0.0 0.12 11.5 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 ORX44254.1 - 0.054 13.9 0.2 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activat PF00158.26 ORX44254.1 - 0.057 13.1 0.0 0.099 12.3 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 ORX44254.1 - 0.065 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_23 PF13476.6 ORX44254.1 - 0.092 13.2 0.1 0.092 13.2 0.1 2.7 1 1 0 2 2 1 0 AAA domain cobW PF02492.19 ORX44254.1 - 0.11 12.1 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ORX44254.1 - 0.14 12.2 0.2 0.59 10.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ORX44254.1 - 0.16 12.0 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain HECT PF00632.25 ORX44255.1 - 1.7e-98 329.9 0.0 2.4e-98 329.4 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 ORX44255.1 - 8.7e-35 118.5 19.7 2.5e-12 46.6 0.4 4.1 4 0 0 4 4 4 3 WW domain C2 PF00168.30 ORX44255.1 - 3e-21 75.7 0.3 7.8e-21 74.3 0.3 1.7 1 0 0 1 1 1 1 C2 domain Lactamase_B PF00753.27 ORX44256.1 - 7.3e-16 58.8 0.7 1.3e-15 57.9 0.7 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ORX44256.1 - 5.1e-15 55.2 0.1 9.7e-15 54.3 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ORX44256.1 - 1.1e-06 28.3 0.4 1.7e-06 27.7 0.4 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX44256.1 - 0.0062 16.4 0.6 0.058 13.3 0.6 2.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain SRF-TF PF00319.18 ORX44257.1 - 3.4e-25 87.3 0.1 5e-25 86.7 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) BPL_LplA_LipB PF03099.19 ORX44258.1 - 1.6e-11 44.2 0.0 2.4e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family OSR1_C PF12202.8 ORX44259.1 - 0.031 14.5 0.2 0.11 12.8 0.1 2.0 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase PF00069.25 ORX44260.1 - 7.5e-67 225.5 0.0 9.1e-67 225.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44260.1 - 2.3e-33 115.6 0.0 3e-33 115.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX44260.1 - 2.4e-06 27.1 0.0 6.1e-06 25.8 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX44260.1 - 0.00022 20.3 0.1 0.0004 19.4 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX44260.1 - 0.0021 16.9 0.0 0.0038 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX44260.1 - 0.014 15.3 1.5 0.016 15.1 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 ORX44260.1 - 0.034 13.8 0.5 1.9 8.1 0.1 2.3 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ORX44260.1 - 0.039 13.3 1.1 0.068 12.5 0.2 2.0 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ORX44260.1 - 0.093 11.8 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Cyclin PF08613.11 ORX44261.1 - 4.1e-13 50.0 0.4 6.5e-13 49.4 0.1 1.4 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 ORX44261.1 - 1.9e-05 24.4 0.1 3e-05 23.8 0.1 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain LANC_like PF05147.13 ORX44261.1 - 0.028 13.0 0.0 0.036 12.6 0.0 1.2 1 0 0 1 1 1 0 Lanthionine synthetase C-like protein TALPID3 PF15324.6 ORX44261.1 - 7.3 4.1 10.5 9.5 3.7 10.5 1.1 1 0 0 1 1 1 0 Hedgehog signalling target TP_methylase PF00590.20 ORX44262.1 - 1.7e-23 83.7 0.1 2.7e-23 83.0 0.1 1.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases YtxH PF12732.7 ORX44263.1 - 0.00062 20.2 5.0 0.027 15.0 2.4 2.3 2 0 0 2 2 2 2 YtxH-like protein EspB PF05802.11 ORX44263.1 - 0.0061 16.6 2.1 0.008 16.2 2.1 1.1 1 0 0 1 1 1 1 Enterobacterial EspB protein Apolipoprotein PF01442.18 ORX44263.1 - 0.023 14.6 0.3 0.029 14.2 0.3 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF5610 PF18433.1 ORX44263.1 - 0.033 14.7 3.0 0.39 11.2 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5610) ERp29 PF07749.12 ORX44263.1 - 0.045 14.6 0.0 0.063 14.2 0.0 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF883 PF05957.13 ORX44263.1 - 0.1 13.2 4.3 0.21 12.2 4.3 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MT0933_antitox PF14013.6 ORX44263.1 - 0.29 11.5 12.7 0.95 9.8 6.9 2.4 1 1 1 2 2 2 0 MT0933-like antitoxin protein ATP-synt_B PF00430.18 ORX44263.1 - 0.66 10.1 4.4 0.9 9.6 4.4 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) SAPS PF04499.15 ORX44264.1 - 7.2e-51 173.5 0.3 3.8e-27 95.2 0.1 2.2 1 1 1 2 2 2 2 SIT4 phosphatase-associated protein SERTA PF06031.13 ORX44265.1 - 0.1 12.3 0.4 0.17 11.6 0.4 1.4 1 0 0 1 1 1 0 SERTA motif DUF688 PF05097.12 ORX44265.1 - 0.15 11.2 3.7 0.2 10.8 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF688) DUF3246 PF11596.8 ORX44265.1 - 0.21 11.0 3.6 0.24 10.8 3.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) zf-AN1 PF01428.16 ORX44266.1 - 3.5e-08 33.5 9.9 4.8e-08 33.0 9.9 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger NAD_binding_10 PF13460.6 ORX44267.1 - 1.8e-16 60.6 0.0 2.8e-16 59.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX44267.1 - 8.4e-16 58.2 0.1 1.2e-15 57.7 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 ORX44267.1 - 1.6e-11 43.9 0.0 6.7e-10 38.5 0.0 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ORX44267.1 - 2.1e-11 43.4 0.1 9.7e-11 41.2 0.0 1.9 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX44267.1 - 3.9e-11 42.9 0.0 6.7e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ORX44267.1 - 6.5e-08 32.9 0.0 1.4e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 ORX44267.1 - 1.5e-06 27.6 0.1 0.04 13.1 0.1 3.0 1 1 1 2 2 2 2 Male sterility protein adh_short PF00106.25 ORX44267.1 - 3e-05 23.6 0.0 4.3e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_2 PF03446.15 ORX44267.1 - 0.00014 22.1 0.0 0.0031 17.7 0.0 2.2 1 1 1 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short_C2 PF13561.6 ORX44267.1 - 0.0025 17.4 0.0 0.0048 16.5 0.0 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.20 ORX44267.1 - 0.0032 17.5 0.0 0.0056 16.7 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 ORX44267.1 - 0.013 14.9 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 ORX44267.1 - 0.022 14.7 0.0 0.11 12.4 0.0 1.9 1 1 0 1 1 1 0 KR domain DUF645 PF04875.12 ORX44267.1 - 0.21 11.7 0.0 0.37 10.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF645 PNP_UDP_1 PF01048.20 ORX44268.1 - 3.5e-28 98.4 0.1 4.3e-28 98.2 0.1 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily BCS1_N PF08740.11 ORX44269.1 - 2e-51 174.6 0.4 3e-51 174.1 0.4 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ORX44269.1 - 2.4e-19 70.1 0.0 4.2e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX44269.1 - 0.00039 20.8 0.1 0.0015 18.9 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 ORX44269.1 - 0.00042 19.5 0.0 0.00065 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ORX44269.1 - 0.0021 18.6 0.0 0.0057 17.2 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 ORX44269.1 - 0.0032 17.2 0.0 0.0072 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_5 PF07728.14 ORX44269.1 - 0.0056 16.7 0.0 0.013 15.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX44269.1 - 0.0057 16.8 0.0 0.015 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ORX44269.1 - 0.01 16.2 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 RNA helicase RuvB_N PF05496.12 ORX44269.1 - 0.012 15.3 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 ORX44269.1 - 0.015 15.0 0.0 0.032 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX44269.1 - 0.018 14.6 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ORX44269.1 - 0.022 15.2 0.0 0.043 14.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 ORX44269.1 - 0.028 14.2 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TruB_C_2 PF16198.5 ORX44269.1 - 0.032 14.4 1.3 0.31 11.2 0.5 2.6 2 0 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain AAA_25 PF13481.6 ORX44269.1 - 0.052 13.1 0.0 0.21 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 ORX44269.1 - 0.057 13.3 0.0 0.3 11.0 0.0 2.1 2 1 1 3 3 2 0 Rad17 P-loop domain AAA_22 PF13401.6 ORX44269.1 - 0.078 13.3 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain PPV_E1_C PF00519.17 ORX44269.1 - 0.094 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase MMR_HSR1 PF01926.23 ORX44269.1 - 0.11 12.5 0.0 0.24 11.5 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase PF06745.13 ORX44269.1 - 0.14 11.5 0.0 0.26 10.6 0.0 1.4 1 0 0 1 1 1 0 KaiC SMC_N PF02463.19 ORX44269.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 ORX44269.1 - 0.17 12.3 0.0 0.57 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain SPRY PF00622.28 ORX44270.1 - 1.9e-21 76.4 0.2 4e-21 75.4 0.2 1.6 1 0 0 1 1 1 1 SPRY domain zf-C2H2 PF00096.26 ORX44271.1 - 1.6e-14 53.4 7.3 1.5e-07 31.4 1.5 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX44271.1 - 1.1e-11 44.5 6.3 2.8e-06 27.7 1.1 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX44271.1 - 1.2e-08 35.0 16.4 3.1e-05 24.2 0.4 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX44271.1 - 3.7e-05 23.6 2.5 0.006 16.6 0.3 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX44271.1 - 0.00033 20.4 5.4 0.026 14.3 0.4 2.1 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ORX44271.1 - 0.00043 20.5 0.2 0.023 15.0 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 ORX44271.1 - 0.00064 20.0 1.1 0.00097 19.4 1.1 1.4 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_SprT PF17283.2 ORX44271.1 - 0.00071 19.4 5.7 0.004 17.0 0.7 2.2 2 0 0 2 2 2 1 SprT-like zinc ribbon domain zf-met PF12874.7 ORX44271.1 - 0.0028 18.0 0.7 0.29 11.6 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 ORX44271.1 - 0.0028 17.4 9.7 0.014 15.2 1.0 2.9 2 1 0 2 2 2 1 C2H2-type zinc-finger domain zf-TRAF PF02176.18 ORX44271.1 - 0.0038 17.9 0.5 0.0045 17.7 0.5 1.1 1 0 0 1 1 1 1 TRAF-type zinc finger zf_UBZ PF18439.1 ORX44271.1 - 0.0088 15.6 0.3 0.059 13.0 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 ORX44271.1 - 0.016 15.1 3.0 1.2 9.1 0.4 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-BED PF02892.15 ORX44271.1 - 0.019 15.0 1.6 3.5 7.7 0.1 2.1 2 0 0 2 2 2 0 BED zinc finger ARS2 PF04959.13 ORX44271.1 - 0.023 15.1 0.3 0.5 10.7 0.0 2.0 1 1 1 2 2 2 0 Arsenite-resistance protein 2 zf-LYAR PF08790.11 ORX44271.1 - 0.05 13.5 0.1 0.56 10.2 0.0 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Zn-C2H2_12 PF18112.1 ORX44271.1 - 1.6 9.3 5.0 5.6 7.5 1.0 2.5 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain DUF2034 PF10356.9 ORX44272.1 - 9.1e-16 57.8 0.0 2.7e-07 30.2 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 ORX44272.1 - 1.2e-06 28.5 0.0 1.7e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Restriction endonuclease Syntaxin PF00804.25 ORX44273.1 - 2.4e-37 128.5 16.8 3.9e-37 127.9 16.8 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 ORX44273.1 - 1.6e-08 34.4 0.2 3.2e-08 33.4 0.2 1.6 1 0 0 1 1 1 1 SNARE domain DUF3671 PF12420.8 ORX44273.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF4094 PF13334.6 ORX44273.1 - 0.015 15.7 0.3 0.015 15.7 0.3 2.5 3 1 0 3 3 2 0 Domain of unknown function (DUF4094) MCU PF04678.13 ORX44273.1 - 0.021 14.9 2.7 0.021 14.9 2.7 2.3 1 1 0 2 2 2 0 Mitochondrial calcium uniporter GNVR PF13807.6 ORX44273.1 - 0.074 13.0 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 G-rich domain on putative tyrosine kinase Phage_GP20 PF06810.11 ORX44273.1 - 0.12 12.1 12.8 0.25 11.2 2.1 2.5 2 1 0 2 2 2 0 Phage minor structural protein GP20 DUF4988 PF16378.5 ORX44273.1 - 0.58 9.8 5.7 0.98 9.1 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function 7tm_7 PF08395.12 ORX44273.1 - 3.5 6.7 8.0 3.3 6.8 0.2 2.4 3 0 0 3 3 3 0 7tm Chemosensory receptor DUF2203 PF09969.9 ORX44273.1 - 4.9 7.9 12.9 3.3 8.5 2.3 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Cnn_1N PF07989.11 ORX44273.1 - 7.4 6.8 9.6 5.2 7.3 1.4 3.2 2 2 0 3 3 3 0 Centrosomin N-terminal motif 1 FAM178 PF14816.6 ORX44274.1 - 0.00036 19.6 2.6 0.021 13.8 2.6 2.4 1 1 0 1 1 1 1 Family of unknown function, FAM178 Ras PF00071.22 ORX44275.1 - 1.7e-43 148.0 0.0 2e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX44275.1 - 9.4e-27 93.6 0.1 1.5e-26 93.0 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX44275.1 - 4.9e-10 39.1 0.0 6.4e-10 38.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX44275.1 - 5e-06 26.0 0.0 1.7e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 ORX44275.1 - 0.00027 19.9 0.0 0.067 12.0 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) PduV-EutP PF10662.9 ORX44275.1 - 0.0021 17.8 0.0 0.35 10.6 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 ORX44275.1 - 0.0027 17.2 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region ATP_bind_1 PF03029.17 ORX44275.1 - 0.0059 16.4 0.0 0.41 10.4 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TniB PF05621.11 ORX44275.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ORX44275.1 - 0.019 15.0 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase TsaE PF02367.17 ORX44275.1 - 0.028 14.4 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 ORX44275.1 - 0.073 13.4 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX44275.1 - 0.073 13.0 0.0 3.1 7.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 ORX44275.1 - 0.091 12.2 0.1 0.19 11.1 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ORX44275.1 - 0.14 12.5 0.0 0.25 11.7 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 ORX44275.1 - 0.18 11.9 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain BAR PF03114.18 ORX44276.1 - 3.9e-22 79.1 0.9 5.6e-22 78.6 0.9 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ORX44276.1 - 7e-16 57.6 0.3 1.2e-15 56.9 0.3 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX44276.1 - 5e-12 45.5 0.1 8.5e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX44276.1 - 2.4e-09 36.7 0.0 5.6e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain DUF2208 PF09973.9 ORX44276.1 - 0.086 12.4 0.5 0.13 11.9 0.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Pkinase PF00069.25 ORX44277.1 - 1.2e-51 175.6 0.0 1.8e-51 175.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44277.1 - 9.9e-35 120.1 0.0 1.4e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX44277.1 - 9.4e-05 21.4 0.0 0.00054 18.8 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX44277.1 - 0.0002 20.8 0.0 0.00033 20.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ORX44277.1 - 0.24 10.4 0.0 0.41 9.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Ras PF00071.22 ORX44278.1 - 4.9e-61 205.1 0.3 5.7e-61 204.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX44278.1 - 2.9e-35 121.1 0.1 4.1e-35 120.6 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX44278.1 - 2.1e-13 50.1 0.1 2.7e-13 49.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX44278.1 - 2.1e-05 24.5 0.1 3.4e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX44278.1 - 2.6e-05 23.9 0.2 8.8e-05 22.1 0.1 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX44278.1 - 0.00016 21.7 0.1 0.015 15.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 ORX44278.1 - 0.00028 20.3 0.0 0.00039 19.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ORX44278.1 - 0.0022 17.8 0.1 0.098 12.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain SRPRB PF09439.10 ORX44278.1 - 0.0084 15.6 0.0 0.014 14.8 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ORX44278.1 - 0.02 15.2 0.0 0.041 14.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 ORX44278.1 - 0.023 13.9 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.27 ORX44278.1 - 0.042 14.4 0.4 0.072 13.6 0.4 1.7 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 ORX44278.1 - 0.065 13.6 0.1 0.1 13.0 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 ORX44278.1 - 0.066 12.5 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Septin FeoB_N PF02421.18 ORX44278.1 - 0.13 11.8 0.2 0.64 9.5 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B Ras PF00071.22 ORX44279.1 - 5e-31 107.5 0.1 5.8e-30 104.0 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ORX44279.1 - 8e-16 58.4 0.0 2.9e-14 53.3 0.0 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX44279.1 - 3.7e-07 29.8 0.0 7.4e-07 28.8 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX44279.1 - 0.012 15.6 0.0 0.032 14.3 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX44279.1 - 0.032 14.2 0.0 5.8 6.8 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 ORX44279.1 - 0.055 12.8 0.0 0.52 9.6 0.0 2.1 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX44279.1 - 0.12 11.8 0.0 1.3 8.4 0.0 2.1 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit PS-DH PF14765.6 ORX44280.1 - 0.0039 16.5 0.4 0.0046 16.2 0.4 1.1 1 0 0 1 1 1 1 Polyketide synthase dehydratase DENN PF02141.21 ORX44281.1 - 0.013 15.5 0.4 0.057 13.4 0.1 2.2 2 0 0 2 2 2 0 DENN (AEX-3) domain Holin_9 PF16936.5 ORX44281.1 - 0.13 12.4 0.1 7.8 6.7 0.0 2.5 2 0 0 2 2 2 0 Putative holin DUF2281 PF10047.9 ORX44282.1 - 0.016 15.9 0.0 0.03 15.0 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2281) DUF3484 PF11983.8 ORX44282.1 - 3.4 8.8 5.9 7.7 7.7 5.9 1.9 1 1 0 1 1 1 0 Membrane-attachment and polymerisation-promoting switch Not1 PF04054.15 ORX44283.1 - 6.9e-85 285.2 3.7 1.3e-84 284.2 3.7 1.4 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 ORX44283.1 - 9.2e-54 182.2 1.2 2.8e-53 180.6 1.2 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 ORX44283.1 - 1.9e-41 141.3 0.0 4e-41 140.3 0.0 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 ORX44283.1 - 3e-30 105.1 0.2 6e-30 104.1 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 ORX44283.1 - 1.2e-29 103.3 2.4 3.4e-29 101.9 2.4 1.8 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Herpes_UL47 PF03362.13 ORX44283.1 - 0.001 18.0 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus UL47 protein Abhydrolase_3 PF07859.13 ORX44285.1 - 4.6e-62 209.6 0.0 5.5e-62 209.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX44285.1 - 2.5e-06 26.6 0.0 3.3e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX44285.1 - 0.00037 20.0 0.1 0.0042 16.6 0.1 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ORX44285.1 - 0.019 13.9 1.0 0.16 10.8 1.0 1.9 1 1 0 1 1 1 0 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX44286.1 - 2e-49 168.3 0.0 2.8e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX44286.1 - 0.16 10.8 0.1 0.18 10.6 0.1 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 ORX44287.1 - 1.1e-58 198.6 0.0 1.4e-58 198.2 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX44287.1 - 1.9e-05 23.7 0.0 2.5e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX44287.1 - 0.0036 16.8 0.0 0.023 14.2 0.0 1.9 1 1 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ORX44287.1 - 0.0089 14.9 0.0 2.8 6.7 0.0 2.1 2 0 0 2 2 2 2 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX44288.1 - 1.6e-57 194.7 0.0 2e-57 194.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX44288.1 - 0.00022 20.2 0.0 0.00026 20.0 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 ORX44288.1 - 0.0021 17.0 0.0 0.017 14.0 0.0 1.9 1 1 0 1 1 1 1 Carboxylesterase family Transketolase_N PF00456.21 ORX44289.1 - 0.00089 18.3 0.0 2.5 7.0 0.0 3.7 1 1 3 4 4 4 2 Transketolase, thiamine diphosphate binding domain UnbV_ASPIC PF07593.12 ORX44289.1 - 0.0044 17.0 2.0 73 3.4 0.0 4.1 4 0 0 4 4 4 0 ASPIC and UnbV PP1 PF07430.11 ORX44289.1 - 0.029 14.4 0.9 1.2e+02 2.8 0.0 3.8 1 1 3 4 4 4 0 Phloem filament protein PP1 cystatin-like domain Desulfoferrod_N PF06397.12 ORX44289.1 - 0.91 9.2 19.3 2.8 7.6 0.3 3.8 4 0 0 4 4 4 0 Desulfoferrodoxin, N-terminal domain DUF1069 PF06370.11 ORX44289.1 - 4.6 6.8 7.4 9.4 5.8 0.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1069) XH PF03469.14 ORX44290.1 - 0.028 14.3 0.7 0.071 13.0 0.7 1.6 1 0 0 1 1 1 0 XH domain Sec16_C PF12931.7 ORX44291.1 - 2.5e-69 234.2 0.1 3.5e-69 233.8 0.1 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 ORX44291.1 - 1.8e-18 67.2 0.1 1.2e-17 64.6 0.1 2.4 1 1 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region DZR PF12773.7 ORX44291.1 - 0.0044 17.0 1.3 0.0096 15.9 1.3 1.5 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 ORX44291.1 - 0.008 15.9 0.9 0.015 15.0 0.9 1.5 1 0 0 1 1 1 1 zinc-ribbon domain SWIB PF02201.18 ORX44292.1 - 0.19 11.6 1.0 0.4 10.6 0.2 2.0 2 0 0 2 2 2 0 SWIB/MDM2 domain zf-RVT PF13966.6 ORX44409.1 - 7.4e-11 42.6 1.2 8.9e-11 42.4 1.2 1.0 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase His_Me_b4a2 PF18275.1 ORX44409.1 - 0.1 12.7 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain PRA1 PF03208.19 ORX44410.1 - 3.4e-28 98.1 0.4 4e-28 97.8 0.4 1.0 1 0 0 1 1 1 1 PRA1 family protein Peptidase_M48 PF01435.18 ORX44411.1 - 2.9e-34 118.5 0.0 6.3e-34 117.5 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M48 DNA_methylase PF00145.17 ORX44412.1 - 2.2e-32 112.8 0.0 7.4e-32 111.0 0.0 1.7 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Ima1_N PF09779.9 ORX44413.1 - 2.8e-17 63.8 13.1 4.7e-17 63.1 13.1 1.4 1 0 0 1 1 1 1 Ima1 N-terminal domain Orthoreo_P17 PF07272.11 ORX44413.1 - 0.0047 17.0 2.0 0.061 13.3 0.2 2.4 2 1 0 2 2 2 1 Orthoreovirus P17 protein Actin PF00022.19 ORX44414.1 - 5e-115 384.4 0.0 3.9e-114 381.4 0.0 1.9 1 1 0 1 1 1 1 Actin ArfGap PF01412.18 ORX44415.1 - 1.8e-29 102.2 0.7 1.1e-28 99.7 0.1 2.3 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DUF4649 PF15507.6 ORX44415.1 - 0.067 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4649) NAD_binding_8 PF13450.6 ORX44416.1 - 1.7e-08 34.6 0.0 4.3e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX44416.1 - 0.0023 17.6 0.0 0.0035 17.0 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 ORX44416.1 - 0.0058 16.6 0.0 0.76 9.7 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ORX44416.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Sterol_MT_C PF08498.10 ORX44417.1 - 8.6e-28 96.4 1.9 1.9e-27 95.4 1.9 1.6 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 ORX44417.1 - 6.4e-20 71.6 0.0 2.2e-19 69.9 0.0 2.0 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX44417.1 - 6.8e-19 68.2 0.0 2.9e-18 66.1 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX44417.1 - 1.9e-18 66.9 0.0 8.1e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX44417.1 - 1.5e-11 44.4 0.0 2.5e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX44417.1 - 1.7e-11 43.9 0.0 3e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX44417.1 - 1.9e-10 41.4 0.1 1e-09 39.0 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain CMAS PF02353.20 ORX44417.1 - 3e-10 39.8 0.1 4.6e-10 39.3 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ORX44417.1 - 0.0037 16.8 0.0 0.0081 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX44417.1 - 0.02 14.9 0.2 0.04 13.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 ORX44417.1 - 0.037 13.6 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 ORX44417.1 - 0.04 13.7 0.1 0.14 11.9 0.1 1.8 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 ORX44417.1 - 0.07 12.7 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 ORX44417.1 - 0.12 11.7 0.0 0.38 10.1 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) AATase PF07247.12 ORX44418.1 - 8.7e-12 44.3 0.0 1e-11 44.1 0.0 1.0 1 0 0 1 1 1 1 Alcohol acetyltransferase WD40 PF00400.32 ORX44419.1 - 2.7e-15 56.5 8.3 0.00018 22.2 0.1 5.4 4 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX44419.1 - 1.4e-05 25.3 0.1 0.043 14.1 0.0 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain zf-RING_2 PF13639.6 ORX44420.1 - 4.3e-10 39.8 14.0 5.9e-10 39.3 10.8 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX44420.1 - 2.2e-06 27.4 9.0 2.2e-06 27.4 9.0 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX44420.1 - 2.9e-06 27.5 11.3 1.2e-05 25.4 11.3 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX44420.1 - 7.6e-05 22.5 8.9 7.6e-05 22.5 8.9 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX44420.1 - 0.00023 20.8 7.6 0.00023 20.8 7.6 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 ORX44420.1 - 0.00054 19.9 6.9 0.00054 19.9 6.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX44420.1 - 0.025 14.6 7.7 0.077 13.1 7.7 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 ORX44420.1 - 0.029 14.5 7.1 0.06 13.5 7.0 1.6 1 1 0 1 1 1 0 KIAA1045 RING finger zf-RING_10 PF16685.5 ORX44420.1 - 0.2 11.8 8.2 0.4 10.9 8.2 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 ORX44420.1 - 0.59 10.2 14.2 0.35 10.9 10.4 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX44420.1 - 2.3 8.1 17.8 0.17 11.7 11.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ORX44420.1 - 3.6 7.5 8.3 23 4.9 8.3 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 ORX44420.1 - 8.4 6.6 11.4 35 4.7 11.4 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain Caskin-Pro-rich PF16907.5 ORX44420.1 - 9.8 6.8 11.6 0.22 12.1 2.5 2.4 3 0 0 3 3 2 0 Proline rich region of Caskin proteins Proteasome PF00227.26 ORX44421.1 - 1.6e-51 174.5 0.1 2e-51 174.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ORX44421.1 - 1.6e-13 49.8 0.0 1.6e-13 49.8 0.0 1.8 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Dpy-30 PF05186.13 ORX44422.1 - 1.5e-14 53.4 0.1 2.1e-14 52.9 0.1 1.2 1 0 0 1 1 1 1 Dpy-30 motif Mito_carr PF00153.27 ORX44423.1 - 3e-78 257.9 1.5 1.5e-25 88.9 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX44423.1 - 1.6e-05 24.2 0.2 0.23 10.6 0.0 3.2 2 1 2 4 4 4 2 Gammaproteobacterial serine protease EF-hand_6 PF13405.6 ORX44423.1 - 0.00086 19.0 0.1 0.0038 17.0 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ORX44423.1 - 0.0029 17.0 0.4 0.009 15.5 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ORX44423.1 - 0.021 15.3 0.4 0.096 13.2 0.4 2.1 1 1 0 1 1 1 0 EF-hand domain pair ANAPC1 PF12859.7 ORX44424.1 - 6.5e-09 36.4 4.2 3.8e-08 34.0 4.2 2.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 ORX44424.1 - 0.0038 17.6 13.9 0.63 10.6 0.3 5.3 6 0 0 6 6 6 3 Proteasome/cyclosome repeat zf-CCCH PF00642.24 ORX44425.1 - 1.5e-17 63.1 44.7 6.3e-06 26.0 2.8 5.2 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX44425.1 - 4.3e-16 58.4 59.4 2.2e-06 27.5 4.1 5.2 5 0 0 5 5 5 5 Zinc finger domain Torus PF16131.5 ORX44425.1 - 8.5e-16 58.6 30.3 3.2e-05 24.6 0.2 5.0 1 1 4 5 5 5 5 Torus domain zf-CCCH_3 PF15663.5 ORX44425.1 - 4.7e-10 39.7 26.4 7e-08 32.7 4.2 2.6 1 1 2 3 3 3 2 Zinc-finger containing family zf-CCCH_4 PF18044.1 ORX44425.1 - 7.1e-08 32.1 52.8 2.1e-06 27.4 1.6 5.2 5 0 0 5 5 5 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX44425.1 - 3.5e-07 30.5 50.3 0.0042 17.5 4.5 5.8 6 0 0 6 6 6 5 RNA-binding, Nab2-type zinc finger V-SNARE PF05008.15 ORX44426.1 - 1.6e-17 63.7 0.5 1.6e-17 63.7 0.5 2.4 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ORX44426.1 - 3.7e-17 62.4 7.8 3.6e-16 59.2 2.9 3.6 3 2 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus EzrA PF06160.12 ORX44426.1 - 1.7e-05 23.2 2.3 1.7e-05 23.2 2.3 2.0 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA Vps53_N PF04100.12 ORX44426.1 - 0.011 14.7 3.3 0.12 11.3 0.8 2.2 2 0 0 2 2 2 0 Vps53-like, N-terminal DUF4407 PF14362.6 ORX44426.1 - 0.049 13.0 5.2 0.067 12.5 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ORX44426.1 - 0.081 12.5 8.4 0.49 9.9 8.4 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Sec20 PF03908.13 ORX44426.1 - 0.13 12.2 1.1 0.37 10.7 0.1 2.2 2 1 0 2 2 2 0 Sec20 BORCS7 PF16088.5 ORX44426.1 - 0.21 11.9 3.0 0.53 10.6 0.1 2.2 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DHR10 PF18595.1 ORX44426.1 - 0.27 11.3 12.5 1.8 8.6 0.5 2.8 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain CENP-H PF05837.12 ORX44426.1 - 2.5 8.5 12.5 0.94 9.9 0.7 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FapA PF03961.13 ORX44426.1 - 4.7 5.7 5.4 2.1 6.9 2.6 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A APG6_N PF17675.1 ORX44426.1 - 5 7.7 14.7 2.3 8.7 8.9 2.2 1 1 0 2 2 2 0 Apg6 coiled-coil region DUF883 PF05957.13 ORX44426.1 - 8.6 7.0 9.1 7.7 7.2 0.6 3.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) eIF2A PF08662.11 ORX44427.1 - 1.2e-33 116.7 5.5 6.8e-27 94.6 0.4 5.8 3 2 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 ORX44427.1 - 1.2e-05 25.1 0.0 3e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 ORX44427.1 - 0.0018 18.6 0.1 72 3.8 0.0 6.1 5 2 2 7 7 7 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX44427.1 - 0.0046 17.8 0.7 0.29 12.1 0.1 4.0 4 1 1 5 5 5 1 WD domain, G-beta repeat DegQ PF08181.11 ORX44427.1 - 0.049 13.7 0.8 0.11 12.7 0.8 1.5 1 0 0 1 1 1 0 DegQ (SacQ) family TFIIIC_delta PF12657.7 ORX44427.1 - 0.069 13.1 3.8 0.75 9.7 0.1 3.4 4 0 0 4 4 4 0 Transcription factor IIIC subunit delta N-term Septin PF00735.18 ORX44428.1 - 6.9e-113 376.6 0.3 1e-112 376.0 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ORX44428.1 - 6.5e-08 32.7 0.1 1.6e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX44428.1 - 0.0023 17.5 0.1 0.019 14.5 0.0 2.2 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX44428.1 - 0.0034 17.5 3.9 0.24 11.4 0.0 3.1 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ORX44428.1 - 0.014 15.3 0.2 0.014 15.3 0.2 2.4 3 1 0 3 3 3 0 RsgA GTPase AIG1 PF04548.16 ORX44428.1 - 0.022 14.1 0.0 0.058 12.7 0.0 1.7 2 0 0 2 2 2 0 AIG1 family FtsK_SpoIIIE PF01580.18 ORX44428.1 - 0.057 12.8 0.1 0.13 11.6 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 ORX44428.1 - 0.067 13.4 0.0 0.19 12.0 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ORX44428.1 - 0.14 12.7 4.4 1.4 9.4 3.6 2.2 2 0 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 ORX44428.1 - 0.18 11.2 0.1 0.31 10.5 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein SH3_9 PF14604.6 ORX44429.1 - 7e-13 48.2 0.1 1.3e-12 47.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX44429.1 - 7.4e-10 38.3 0.1 1.3e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX44429.1 - 6.3e-06 25.8 0.1 1.3e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain Nup188 PF10487.9 ORX44431.1 - 1.1e-33 116.2 15.3 3.8e-17 61.6 3.3 3.0 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 Gcn1_N PF12074.8 ORX44432.1 - 2.8e-58 197.9 0.1 2.8e-58 197.9 0.1 4.3 6 1 1 7 7 7 1 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT PF02985.22 ORX44432.1 - 1.4e-40 133.8 27.7 0.0062 16.7 0.0 21.0 22 1 1 23 23 21 9 HEAT repeat HEAT_EZ PF13513.6 ORX44432.1 - 3.5e-33 113.6 17.9 1.4e-05 25.5 0.0 16.2 13 4 3 16 16 15 6 HEAT-like repeat HEAT_2 PF13646.6 ORX44432.1 - 3.3e-29 101.1 18.3 0.0011 19.3 0.2 13.8 10 2 4 15 15 15 7 HEAT repeats Cnd1 PF12717.7 ORX44432.1 - 1.4e-18 67.5 2.0 0.011 15.7 0.1 9.8 7 2 3 10 10 10 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX44432.1 - 1.3e-12 47.8 0.2 0.031 13.8 0.0 7.6 7 1 1 8 8 8 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 ORX44432.1 - 1.5e-11 44.7 0.0 0.073 13.7 0.0 8.2 7 2 1 8 8 7 2 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ORX44432.1 - 1.2e-09 37.3 10.4 0.11 11.0 0.7 7.8 6 2 1 7 7 7 3 Adaptin N terminal region MMS19_C PF12460.8 ORX44432.1 - 3.3e-09 36.4 14.9 0.0002 20.6 0.0 7.5 5 2 4 9 9 9 3 RNAPII transcription regulator C-terminal UME PF08064.13 ORX44432.1 - 8.1e-07 28.9 1.9 0.52 10.2 0.0 8.0 8 2 3 11 11 11 1 UME (NUC010) domain DUF3385 PF11865.8 ORX44432.1 - 1.4e-05 25.0 0.0 3.6 7.5 0.0 6.9 8 2 0 8 8 7 1 Domain of unknown function (DUF3385) Arm PF00514.23 ORX44432.1 - 3.7e-05 23.6 0.5 1.8 8.7 0.0 6.4 5 1 1 6 6 5 1 Armadillo/beta-catenin-like repeat Phage_TAC_9 PF10876.8 ORX44432.1 - 0.00065 19.8 0.1 0.52 10.4 0.0 3.2 3 0 0 3 3 3 1 Phage tail assemb.y chaperone protein, TAC ParcG PF10274.9 ORX44432.1 - 0.0012 19.0 3.1 16 5.6 0.0 6.4 5 2 2 7 7 7 0 Parkin co-regulated protein NUC173 PF08161.12 ORX44432.1 - 0.0013 18.5 5.1 1 9.0 0.0 6.0 7 1 1 8 8 8 1 NUC173 domain Ecm29 PF13001.7 ORX44432.1 - 0.003 16.3 1.5 10 4.7 0.4 6.0 7 0 0 7 7 7 0 Proteasome stabiliser DUF4042 PF13251.6 ORX44432.1 - 0.0042 16.8 1.6 5.5 6.7 0.0 6.0 6 1 0 7 7 7 1 Domain of unknown function (DUF4042) L27 PF02828.16 ORX44432.1 - 0.0044 16.7 5.3 0.67 9.8 0.1 4.3 4 0 0 4 4 4 1 L27 domain Dopey_N PF04118.14 ORX44432.1 - 0.017 14.2 3.5 18 4.4 0.0 5.1 5 1 0 5 5 5 0 Dopey, N-terminal Cnd3 PF12719.7 ORX44432.1 - 0.048 12.9 0.7 87 2.2 0.0 4.9 5 0 0 5 5 5 0 Nuclear condensing complex subunits, C-term domain RIX1 PF08167.12 ORX44432.1 - 0.05 13.3 9.9 2.7 7.7 0.1 5.7 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis FANCI_S2 PF14676.6 ORX44432.1 - 0.32 11.3 3.6 58 3.9 0.1 4.8 5 0 0 5 5 4 0 FANCI solenoid 2 CLASP_N PF12348.8 ORX44434.1 - 1.3e-54 185.2 0.1 2.4e-54 184.3 0.1 1.5 1 0 0 1 1 1 1 CLASP N terminal V-ATPase_H_C PF11698.8 ORX44434.1 - 0.036 14.2 0.0 0.19 11.8 0.0 2.2 1 0 0 1 1 1 0 V-ATPase subunit H HEAT PF02985.22 ORX44434.1 - 0.12 12.7 0.0 40 4.8 0.0 3.7 4 0 0 4 4 4 0 HEAT repeat TEA PF01285.18 ORX44435.1 - 5.3e-32 109.7 0.0 8.8e-32 109.0 0.0 1.4 1 0 0 1 1 1 1 TEA/ATTS domain YBD PF17725.1 ORX44435.1 - 0.00036 20.5 0.1 0.00066 19.6 0.1 1.4 1 0 0 1 1 1 1 YAP binding domain WRKY PF03106.15 ORX44436.1 - 0.00065 19.9 0.0 0.002 18.3 0.0 1.8 1 0 0 1 1 1 1 WRKY DNA -binding domain ANAPC4_WD40 PF12894.7 ORX44437.1 - 1.2e-05 25.5 1.1 0.57 10.5 0.2 4.7 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ORX44437.1 - 2.6e-05 24.0 1.4 0.22 11.5 0.0 3.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 ORX44437.1 - 0.00016 22.4 7.5 0.79 10.7 0.1 6.2 6 1 1 7 7 7 1 WD domain, G-beta repeat Glyco_hydro_75 PF07335.11 ORX44437.1 - 0.054 13.8 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 Fungal chitosanase of glycosyl hydrolase group 75 Unstab_antitox PF09720.10 ORX44438.1 - 3.4 7.8 3.9 26 5.0 0.0 2.9 2 1 1 3 3 3 0 Putative addiction module component tRNA_U5-meth_tr PF05958.11 ORX44441.1 - 7.8e-16 58.0 0.5 9.6e-15 54.4 0.5 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Cons_hypoth95 PF03602.15 ORX44441.1 - 9.1e-08 32.0 0.0 1.5e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 ORX44441.1 - 1.1e-06 28.3 0.1 1.8e-06 27.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ORX44441.1 - 7.3e-05 22.6 0.4 0.00015 21.6 0.2 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 ORX44441.1 - 0.00015 21.3 0.2 0.00037 20.1 0.2 1.6 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 ORX44441.1 - 0.00064 19.2 1.3 0.0011 18.4 1.2 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ORX44441.1 - 0.0022 18.7 0.2 0.0058 17.3 0.2 1.9 1 1 0 1 1 1 1 Methyltransferase domain AviRa PF11599.8 ORX44441.1 - 0.0054 16.2 0.1 0.0084 15.6 0.1 1.3 1 0 0 1 1 1 1 RRNA methyltransferase AviRa Met_10 PF02475.16 ORX44441.1 - 0.0056 16.4 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_4 PF02390.17 ORX44441.1 - 0.026 14.0 0.5 0.052 13.0 0.1 1.8 2 0 0 2 2 2 0 Putative methyltransferase YdfZ PF14001.6 ORX44441.1 - 0.026 14.9 0.0 0.057 13.8 0.0 1.6 1 0 0 1 1 1 0 YdfZ protein FliS_cochap PF16522.5 ORX44441.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 Methyltransf_32 PF13679.6 ORX44441.1 - 0.038 14.0 0.1 0.065 13.2 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 ORX44441.1 - 0.087 12.5 0.1 0.14 11.9 0.1 1.3 1 0 0 1 1 1 0 Lysine methyltransferase O-FucT PF10250.9 ORX44442.1 - 5.9e-21 75.5 0.0 2.3e-12 47.3 0.0 3.3 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase PI3_PI4_kinase PF00454.27 ORX44443.1 - 1.8e-55 188.5 0.1 4.1e-55 187.3 0.1 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ORX44443.1 - 2.4e-14 53.3 7.3 2.3e-13 50.1 7.3 2.4 1 1 0 1 1 1 1 FAT domain FATC PF02260.20 ORX44443.1 - 6.5e-14 51.4 0.1 7.4e-12 44.9 0.0 2.6 2 0 0 2 2 2 1 FATC domain DUF3385 PF11865.8 ORX44443.1 - 0.0021 18.0 0.0 0.0081 16.1 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3385) UME PF08064.13 ORX44443.1 - 0.0085 16.0 0.8 0.21 11.5 0.0 3.6 4 0 0 4 4 4 1 UME (NUC010) domain Nudix_hydro PF18290.1 ORX44443.1 - 0.02 14.9 0.0 0.062 13.3 0.0 1.8 1 0 0 1 1 1 0 Nudix hydrolase domain Zw10 PF06248.13 ORX44444.1 - 4.1e-15 55.4 1.9 3e-08 32.7 0.1 2.2 2 0 0 2 2 2 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 ORX44444.1 - 5.5e-06 26.2 0.5 5.5e-06 26.2 0.5 2.1 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal Rtf2 PF04641.12 ORX44445.1 - 2.6e-56 190.9 0.4 3.1e-56 190.6 0.4 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger zf-Nse PF11789.8 ORX44445.1 - 0.12 12.2 0.0 1.1 9.2 0.0 2.3 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Ribosomal_L14 PF00238.19 ORX44446.1 - 1.8e-47 160.4 0.9 2e-47 160.3 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e zf-C2H2_10 PF16588.5 ORX44447.1 - 0.00023 20.8 5.0 0.00023 20.8 5.0 2.0 2 0 0 2 2 2 1 C2H2 zinc-finger TFIIA PF03153.13 ORX44448.1 - 7.7 6.4 6.9 8.4 6.3 6.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DNA_topoisoIV PF00521.20 ORX44449.1 - 5.7e-117 391.2 0.0 1.2e-116 390.2 0.0 1.5 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ORX44449.1 - 3.9e-48 162.9 3.0 1.8e-47 160.8 3.0 2.3 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ORX44449.1 - 6.2e-25 87.7 1.7 1.6e-24 86.4 1.7 1.6 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ORX44449.1 - 4.1e-13 49.8 0.1 2.2e-12 47.4 0.0 2.4 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ORX44449.1 - 5.5e-07 29.8 0.1 3.6e-06 27.1 0.0 2.5 2 0 0 2 2 2 1 Toprim domain Nmad5 PF18757.1 ORX44449.1 - 0.025 14.8 2.0 4 7.6 0.3 2.7 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 Mitofilin PF09731.9 ORX44449.1 - 2.2 7.0 8.3 3.7 6.3 8.3 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Recep_L_domain PF01030.24 ORX44450.1 - 2e-08 34.3 2.1 0.35 11.0 0.0 5.2 1 1 2 4 4 4 4 Receptor L domain DUF4113 PF13438.6 ORX44451.1 - 0.003 17.6 0.2 0.0096 16.0 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4113) Proteasome PF00227.26 ORX44452.1 - 1e-51 175.1 0.4 1.2e-51 174.9 0.4 1.0 1 0 0 1 1 1 1 Proteasome subunit 2OG-FeII_Oxy_2 PF13532.6 ORX44453.1 - 0.0026 18.0 0.0 0.015 15.5 0.0 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CMAS PF02353.20 ORX44454.1 - 1.7e-62 211.2 1.2 2.1e-62 210.9 1.2 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 ORX44454.1 - 2.6e-11 44.0 0.0 5.3e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX44454.1 - 2.4e-10 40.5 0.0 4.1e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX44454.1 - 1.1e-09 38.8 0.0 1.9e-09 38.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX44454.1 - 2.7e-07 31.3 0.0 4.9e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX44454.1 - 3.9e-07 30.0 0.0 6.6e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 ORX44454.1 - 0.00043 19.9 0.0 0.00069 19.2 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 MTS PF05175.14 ORX44454.1 - 0.0015 18.1 0.7 0.0023 17.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX44454.1 - 0.003 17.1 0.0 0.0054 16.2 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 ORX44454.1 - 0.048 13.4 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Sugar_tr PF00083.24 ORX44455.1 - 3.9e-87 293.0 27.1 4.9e-87 292.7 27.1 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX44455.1 - 1.8e-24 86.4 33.0 1.8e-24 86.4 33.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily SpoIIIAC PF06686.11 ORX44455.1 - 0.043 14.0 1.5 0.21 11.8 0.9 2.5 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family OrfB_Zn_ribbon PF07282.11 ORX44456.1 - 0.0024 17.8 0.1 0.0035 17.2 0.1 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Glyco_hydro_3 PF00933.21 ORX44457.1 - 3e-85 286.4 0.0 4.2e-85 285.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 ORX44457.1 - 2.1e-10 40.8 0.0 1.3e-09 38.3 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX44457.1 - 1.9e-07 31.1 0.0 8.7e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX44457.1 - 6e-07 29.8 0.0 2e-06 28.1 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX44457.1 - 4.7e-06 26.7 0.0 1.6e-05 25.0 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX44457.1 - 0.00017 21.5 0.1 0.00077 19.4 0.1 2.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ORX44457.1 - 0.0015 18.7 0.0 0.0039 17.3 0.0 1.7 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Glyco_hydro_3_C PF01915.22 ORX44457.1 - 0.0066 16.4 0.0 0.012 15.6 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain GCP_N_terminal PF17681.1 ORX44458.1 - 4.3e-13 49.6 0.2 5.6e-13 49.2 0.2 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal AbiTii PF18864.1 ORX44458.1 - 0.036 14.2 0.3 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 AbiTii GCP_C_terminal PF04130.13 ORX44459.1 - 5.4e-21 75.4 4.4 4.3e-20 72.4 0.4 2.0 1 1 1 2 2 2 2 Gamma tubulin complex component C-terminal DUF5413 PF17434.2 ORX44459.1 - 0.057 13.7 0.1 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5413) IMS PF00817.20 ORX44461.1 - 2e-45 154.4 0.1 2.8e-44 150.7 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family zf_UBZ PF18439.1 ORX44461.1 - 5.3e-09 35.5 0.6 5.3e-09 35.5 0.6 2.5 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger IMS_C PF11799.8 ORX44461.1 - 0.00016 22.3 0.0 0.00037 21.2 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ORX44461.1 - 0.0018 18.5 0.0 0.0042 17.3 0.0 1.6 1 0 0 1 1 1 1 IMS family HHH motif DUF4218 PF13960.6 ORX44564.1 - 6.8e-05 22.5 0.0 0.00022 20.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4218) Transposase_21 PF02992.14 ORX44564.1 - 0.025 13.8 0.1 0.054 12.7 0.1 1.5 1 0 0 1 1 1 0 Transposase family tnp2 DUF1258 PF06869.12 ORX44564.1 - 0.11 12.0 0.1 0.18 11.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DUF2924 PF11149.8 ORX44566.1 - 0.033 14.6 0.1 0.041 14.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) ParB PF08775.10 ORX44566.1 - 0.064 13.7 1.5 0.079 13.4 1.5 1.2 1 0 0 1 1 1 0 ParB family FtsK_SpoIIIE_N PF12538.8 ORX44566.1 - 0.12 12.6 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 DNA transporter Mqo PF06039.15 ORX44568.1 - 0.14 10.7 0.2 0.19 10.2 0.2 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Methyltransf_11 PF08241.12 ORX44572.1 - 4e-13 49.8 0.0 6.2e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX44572.1 - 2e-11 44.4 0.2 4e-11 43.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX44572.1 - 1.1e-06 28.6 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX44572.1 - 1.7e-06 28.7 0.0 4.3e-06 27.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX44572.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Reprolysin_4 PF13583.6 ORX44573.1 - 0.0012 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like HLH PF00010.26 ORX44574.1 - 1.1e-17 63.7 0.3 4.3e-17 61.8 0.0 2.0 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain LMBR1 PF04791.16 ORX44574.1 - 0.026 13.5 0.9 0.033 13.1 0.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Cep57_MT_bd PF06657.13 ORX44574.1 - 0.031 14.7 3.5 0.38 11.2 0.1 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF1978 PF09321.10 ORX44574.1 - 0.11 11.8 2.9 0.08 12.3 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1978) PspB PF06667.12 ORX44574.1 - 0.83 9.8 0.1 0.83 9.8 0.1 2.2 2 1 0 2 2 2 0 Phage shock protein B ZapB PF06005.12 ORX44574.1 - 1.2 9.6 0.0 1.2 9.6 0.0 2.3 2 0 0 2 2 2 0 Cell division protein ZapB PPR PF01535.20 ORX44575.1 - 0.00036 20.6 0.1 2.1 8.8 0.0 4.0 5 0 0 5 5 5 2 PPR repeat BTAD PF03704.17 ORX44575.1 - 0.02 15.3 5.8 0.12 12.8 1.6 3.3 2 2 1 3 3 3 0 Bacterial transcriptional activator domain PPR_2 PF13041.6 ORX44575.1 - 0.095 12.9 0.0 6.6 7.0 0.0 3.1 3 0 0 3 3 3 0 PPR repeat family Septin PF00735.18 ORX44576.1 - 5.4e-113 376.9 0.0 9.3e-113 376.2 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX44576.1 - 7.5e-08 32.4 0.1 2.1e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX44576.1 - 0.00026 20.6 0.8 0.0017 17.9 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX44576.1 - 0.0012 18.7 1.7 0.0026 17.7 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ORX44576.1 - 0.0018 17.7 0.0 0.004 16.5 0.0 1.6 1 0 0 1 1 1 1 AIG1 family FtsK_SpoIIIE PF01580.18 ORX44576.1 - 0.048 13.0 0.2 0.11 11.8 0.2 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family GBP_C PF02841.14 ORX44576.1 - 0.06 12.7 8.6 0.093 12.1 8.6 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Roc PF08477.13 ORX44576.1 - 0.093 13.0 0.0 0.73 10.1 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ORX44576.1 - 0.12 12.5 6.2 2.4 8.2 0.0 3.1 2 1 1 3 3 3 0 Dynamin family AAA_22 PF13401.6 ORX44576.1 - 0.16 12.2 1.1 1.2 9.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain EB1 PF03271.17 ORX44576.1 - 0.17 12.1 1.3 0.8 10.0 1.3 2.2 1 0 0 1 1 1 0 EB1-like C-terminal motif AAA_23 PF13476.6 ORX44576.1 - 1.2 9.6 8.9 14 6.1 8.4 2.2 2 0 0 2 2 2 0 AAA domain DUF4140 PF13600.6 ORX44576.1 - 2.2 8.8 6.3 66 4.0 5.1 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Ras PF00071.22 ORX44577.1 - 1.2e-51 174.6 0.1 1.5e-51 174.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX44577.1 - 4.2e-30 104.4 0.0 6.5e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX44577.1 - 1.5e-14 53.9 0.1 1.8e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX44577.1 - 6.2e-06 25.9 0.0 0.00012 21.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX44577.1 - 2.8e-05 24.1 0.0 0.013 15.4 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX44577.1 - 7.8e-05 22.7 0.0 0.00011 22.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX44577.1 - 0.00017 21.1 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX44577.1 - 0.00018 21.0 0.0 0.00025 20.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ORX44577.1 - 0.047 13.2 0.0 0.21 11.1 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ORX44577.1 - 0.059 13.1 0.1 0.096 12.4 0.1 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1_Xtn PF16897.5 ORX44577.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Glyco_hydro_15 PF00723.21 ORX44578.1 - 3.3e-73 247.0 0.3 5.5e-73 246.3 0.3 1.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 GCP_N_terminal PF17681.1 ORX44579.1 - 9.3e-34 117.4 0.4 9.3e-34 117.4 0.4 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ORX44579.1 - 6.5e-26 91.5 11.8 6.5e-26 91.5 11.8 2.3 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal Ribosomal_L30 PF00327.20 ORX44580.1 - 2.7e-10 40.0 0.0 3.9e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ebp2 PF05890.12 ORX44581.1 - 1.8e-58 198.2 19.1 1.8e-58 198.2 19.1 1.6 1 1 1 2 2 2 1 Eukaryotic rRNA processing protein EBP2 RPN2_C PF18004.1 ORX44581.1 - 10 6.0 25.8 1 9.3 9.9 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Ribosomal_L27 PF01016.19 ORX44582.1 - 6.2e-39 131.9 0.7 7.4e-39 131.6 0.7 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein PXA PF02194.15 ORX44583.1 - 3e-47 161.0 0.5 3.8e-46 157.4 0.2 2.8 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 ORX44583.1 - 5e-27 94.7 4.1 5.8e-27 94.5 1.5 2.6 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 ORX44583.1 - 2.8e-19 69.2 0.1 9.7e-19 67.4 0.1 1.9 1 0 0 1 1 1 1 PX domain RGS PF00615.19 ORX44583.1 - 1.7e-17 63.8 1.1 6.4e-17 61.9 0.4 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain Snf7 PF03357.21 ORX44583.1 - 0.062 12.9 3.0 0.18 11.4 3.0 1.8 1 0 0 1 1 1 0 Snf7 DS PF01916.17 ORX44584.1 - 9.4e-134 445.1 0.0 1.1e-133 444.9 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Rhomboid PF01694.22 ORX44585.1 - 4.7e-18 65.6 6.1 6.3e-18 65.2 6.1 1.1 1 0 0 1 1 1 1 Rhomboid family KH_1 PF00013.29 ORX44586.1 - 1.4e-43 146.5 4.8 2.3e-16 59.4 0.1 3.1 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ORX44586.1 - 3.6e-10 39.5 5.2 0.033 14.0 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 ORX44586.1 - 9.8e-09 35.0 4.0 0.085 12.7 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 ORX44586.1 - 2.3e-05 24.4 2.9 0.035 14.2 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain LIM PF00412.22 ORX44587.1 - 8e-22 77.2 68.1 1.7e-07 31.3 3.1 6.5 6 2 2 8 8 8 4 LIM domain CN_hydrolase PF00795.22 ORX44588.1 - 2e-40 138.8 0.0 2.8e-40 138.3 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 ORX44588.1 - 3.9e-24 85.1 0.0 1.6e-23 83.1 0.0 1.9 1 1 0 1 1 1 1 NAD synthase RNA_pol_3_Rpc31 PF11705.8 ORX44589.1 - 3.3e-29 102.8 11.4 3.3e-29 102.8 11.4 1.8 1 1 1 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 ORX44589.1 - 1.8 8.3 14.8 8.1 6.2 1.3 2.2 1 1 1 2 2 2 0 Pox virus Ag35 surface protein Astro_capsid_p PF12226.8 ORX44589.1 - 3 6.9 12.2 3.6 6.7 12.2 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein BTV_NS2 PF04514.12 ORX44589.1 - 5.1 5.8 9.8 6.9 5.4 9.8 1.2 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 HECT PF00632.25 ORX44590.1 - 3.5e-91 305.9 0.6 4.9e-91 305.4 0.6 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UQ_con PF00179.26 ORX44591.1 - 1.4e-21 76.6 0.0 1.9e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX44591.1 - 0.028 14.7 0.0 0.05 13.9 0.0 1.4 1 0 0 1 1 1 0 RWD domain Smg8_Smg9 PF10220.9 ORX44592.1 - 0.00058 18.3 0.0 0.00086 17.8 0.0 1.3 1 0 0 1 1 1 1 Smg8_Smg9 NB-ARC PF00931.22 ORX44592.1 - 0.0011 18.2 0.0 0.002 17.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MMR_HSR1 PF01926.23 ORX44592.1 - 0.0026 17.8 0.0 0.006 16.6 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX44592.1 - 0.0041 17.0 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ORX44592.1 - 0.0095 16.3 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain KAP_NTPase PF07693.14 ORX44592.1 - 0.011 15.0 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain ABC_tran PF00005.27 ORX44592.1 - 0.028 15.0 0.1 0.084 13.4 0.1 1.7 1 1 0 1 1 1 0 ABC transporter MeaB PF03308.16 ORX44592.1 - 0.034 13.1 0.0 0.056 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 ORX44592.1 - 0.046 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 ORX44592.1 - 0.055 13.2 0.1 0.13 12.0 0.0 1.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Roc PF08477.13 ORX44592.1 - 0.15 12.3 0.0 0.44 10.8 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase XPA_N PF01286.18 ORX44592.1 - 0.29 11.2 1.8 6 7.0 0.2 2.4 2 0 0 2 2 2 0 XPA protein N-terminal Dabb PF07876.12 ORX44593.1 - 3.2e-24 85.4 0.3 3.5e-24 85.2 0.3 1.0 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain Arabino_trans_C PF14896.6 ORX44593.1 - 0.1 11.6 0.0 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 EmbC C-terminal domain DUF21 PF01595.20 ORX44594.1 - 2.4e-33 115.3 0.5 4.9e-33 114.3 0.5 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ORX44594.1 - 2.3e-08 34.4 0.6 0.01 16.2 0.2 2.7 3 0 0 3 3 3 2 CBS domain HVSL PF09749.9 ORX44595.1 - 3e-38 131.7 0.4 2.4e-37 128.7 0.4 1.9 1 1 0 1 1 1 1 Uncharacterised conserved protein 2_5_RNA_ligase2 PF13563.6 ORX44595.1 - 8.1e-06 25.8 0.1 1.7e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily GAS2 PF02187.17 ORX44596.1 - 2e-08 34.2 0.0 5.6e-08 32.8 0.0 1.8 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 ORX44596.1 - 2.9e-06 27.4 0.2 6.5e-05 23.1 0.0 3.6 4 0 0 4 4 4 1 Calponin homology (CH) domain DUF4600 PF15372.6 ORX44596.1 - 4.3 7.8 8.0 9 6.7 0.9 3.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) EphA2_TM PF14575.6 ORX44597.1 - 0.31 12.0 3.8 3.4 8.6 3.8 2.4 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SWIM PF04434.17 ORX44599.1 - 0.053 13.2 0.4 0.13 11.9 0.4 1.7 1 0 0 1 1 1 0 SWIM zinc finger Ribosomal_L6 PF00347.23 ORX44600.1 - 3.6e-30 104.4 4.9 1.1e-18 67.6 1.4 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Herpes_U34 PF04541.13 ORX44600.1 - 0.04 13.2 0.3 0.054 12.8 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus virion protein U34 DHO_dh PF01180.21 ORX44601.1 - 1.5e-60 205.0 0.0 1.7e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ORX44601.1 - 0.035 13.1 0.2 0.05 12.6 0.2 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Vps26 PF03643.15 ORX44602.1 - 1.2e-113 378.7 3.2 1.5e-113 378.4 3.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ORX44602.1 - 0.0042 17.2 0.7 1.2 9.2 0.1 3.3 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain TPP_enzyme_N PF02776.18 ORX44603.1 - 4e-56 189.3 0.1 2.8e-55 186.6 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ORX44603.1 - 2.1e-52 177.0 0.5 2.1e-50 170.5 0.2 3.2 3 1 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ORX44603.1 - 2.6e-41 140.6 0.4 5.5e-41 139.5 0.1 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain 3-PAP PF12578.8 ORX44603.1 - 0.04 13.7 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 Myotubularin-associated protein POR_N PF01855.19 ORX44603.1 - 0.099 12.4 0.1 0.21 11.3 0.1 1.5 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Iso_dh PF00180.20 ORX44604.1 - 1.9e-122 408.8 0.0 2.3e-122 408.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Methyltransf_16 PF10294.9 ORX44605.1 - 7.5e-41 139.7 0.0 8.9e-41 139.5 0.0 1.0 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ORX44605.1 - 2.5e-06 27.1 0.0 3.7e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ORX44605.1 - 3.4e-05 23.4 0.0 4.7e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.6 ORX44605.1 - 0.00019 22.1 0.0 0.00036 21.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX44605.1 - 0.00058 19.7 0.0 0.00096 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GidB PF02527.15 ORX44605.1 - 0.0023 17.3 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_11 PF08241.12 ORX44605.1 - 0.025 15.2 0.0 0.044 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ORX44605.1 - 0.033 14.0 0.0 0.05 13.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Sulfate_transp PF00916.20 ORX44607.1 - 1.9e-97 326.4 22.5 2.5e-97 326.0 22.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX44607.1 - 3.2e-25 88.0 0.0 5.6e-25 87.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX44607.1 - 8.5e-05 22.9 4.2 8.5e-05 22.9 4.2 3.2 3 1 0 3 3 3 1 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ORX44607.1 - 0.025 14.9 0.0 0.062 13.6 0.0 1.7 1 0 0 1 1 1 0 STAS domain DUF373 PF04123.13 ORX44607.1 - 2.9 7.3 15.4 2.1 7.7 3.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF373) MWFE PF15879.5 ORX44608.1 - 5.8e-23 80.8 0.0 7.2e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Maf PF02545.14 ORX44609.1 - 9e-52 175.3 0.0 1e-51 175.1 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Tugs PF17840.1 ORX44609.1 - 0.033 14.4 0.5 0.077 13.2 0.3 1.7 1 1 0 1 1 1 0 Tethering Ubl4a to BAGS domain zf-C2H2 PF00096.26 ORX44610.1 - 3.8e-11 42.8 31.6 3.6e-05 24.0 0.1 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX44610.1 - 5.9e-08 32.8 21.5 0.00081 19.7 0.6 5.4 5 1 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX44610.1 - 2.3e-05 24.8 28.9 0.0028 18.4 0.1 4.7 4 1 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 ORX44610.1 - 0.0016 19.0 11.8 0.051 14.2 0.2 4.1 2 2 2 4 4 4 1 FOXP coiled-coil domain Zap1_zf2 PF18217.1 ORX44610.1 - 0.02 14.9 9.0 0.06 13.4 0.3 2.8 2 0 0 2 2 2 0 Zap1 zinc finger 2 Mad3_BUB1_I PF08311.12 ORX44610.1 - 0.073 13.1 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Mad3/BUB1 homology region 1 DUF3770 PF12603.8 ORX44610.1 - 0.11 12.0 0.0 7.9 5.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3770) zf-C2H2_6 PF13912.6 ORX44610.1 - 0.19 11.8 0.1 0.19 11.8 0.1 5.0 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX44610.1 - 3.6 7.7 15.7 3.6 7.7 0.0 3.6 2 1 2 4 4 4 0 Aberrant zinc-finger zf-C2H2_9 PF16293.5 ORX44612.1 - 0.019 14.8 0.6 0.035 13.9 0.6 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) ABC_membrane PF00664.23 ORX44613.1 - 1.1e-78 264.6 23.3 7.3e-41 140.6 2.5 2.4 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX44613.1 - 2.3e-51 173.9 0.0 2.4e-28 99.3 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX44613.1 - 7.9e-09 35.3 8.8 0.0002 20.9 0.4 4.2 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX44613.1 - 1.4e-06 28.8 0.3 0.064 13.6 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain MMR_HSR1 PF01926.23 ORX44613.1 - 3.3e-06 27.2 0.9 0.023 14.8 0.1 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF87 PF01935.17 ORX44613.1 - 7.9e-06 26.1 1.3 0.026 14.6 0.1 2.4 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_21 PF13304.6 ORX44613.1 - 3.9e-05 23.6 0.3 1.5 8.6 0.0 3.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX44613.1 - 0.00044 20.2 0.4 0.059 13.3 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ORX44613.1 - 0.00056 19.6 2.3 0.77 9.5 0.2 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX44613.1 - 0.0023 18.2 0.5 2.2 8.6 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX44613.1 - 0.016 14.8 0.4 2.4 7.6 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX44613.1 - 0.022 14.0 0.1 1.2 8.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 ORX44613.1 - 0.064 13.8 0.0 21 5.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 ORX44613.1 - 0.07 12.0 0.6 1.3 7.9 0.1 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_25 PF13481.6 ORX44613.1 - 0.07 12.7 0.4 6.1 6.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain TEX13 PF15186.6 ORX44613.1 - 0.091 12.4 0.2 0.37 10.5 0.3 2.0 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family Roc PF08477.13 ORX44613.1 - 0.093 12.9 0.2 26 5.0 0.0 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ORX44613.1 - 0.12 12.5 7.7 0.1 12.7 0.4 2.8 3 0 0 3 3 2 0 Dynamin family AAA_30 PF13604.6 ORX44613.1 - 0.13 12.0 0.6 6.6 6.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 ORX44613.1 - 0.14 11.3 0.4 1.6 7.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 ORX44613.1 - 0.16 12.1 0.8 27 4.9 0.1 3.0 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX44613.1 - 0.29 11.1 2.6 20 5.1 0.1 3.0 3 0 0 3 3 3 0 NACHT domain NB-ARC PF00931.22 ORX44613.1 - 0.46 9.6 3.5 6.8 5.8 0.2 2.6 3 0 0 3 3 3 0 NB-ARC domain ABC_membrane PF00664.23 ORX44614.1 - 1.8e-83 280.3 24.0 4e-43 148.1 5.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX44614.1 - 1.3e-52 177.9 0.0 4.5e-28 98.5 0.0 2.9 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ORX44614.1 - 1.5e-09 37.7 5.3 0.00047 19.7 0.1 4.4 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX44614.1 - 9.3e-07 28.9 0.2 0.013 15.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX44614.1 - 3.4e-06 27.6 2.1 0.036 14.5 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 ORX44614.1 - 1.6e-05 25.1 0.4 0.031 14.4 0.0 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain RsgA_GTPase PF03193.16 ORX44614.1 - 0.00014 21.8 0.1 0.018 15.0 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 ORX44614.1 - 0.00018 21.5 0.7 4.1 7.1 0.0 3.6 2 1 1 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX44614.1 - 0.00077 19.2 3.2 0.57 10.0 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX44614.1 - 0.0055 17.0 1.1 2.6 8.3 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX44614.1 - 0.0062 16.1 0.9 1.3 8.5 0.1 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region TrwB_AAD_bind PF10412.9 ORX44614.1 - 0.009 15.0 0.4 0.75 8.6 0.0 2.2 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Zeta_toxin PF06414.12 ORX44614.1 - 0.011 15.1 0.2 0.61 9.3 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Dynamin_N PF00350.23 ORX44614.1 - 0.011 15.7 4.2 0.086 12.9 0.3 2.6 2 0 0 2 2 2 0 Dynamin family AAA_25 PF13481.6 ORX44614.1 - 0.021 14.4 0.5 1.5 8.4 0.1 2.5 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ORX44614.1 - 0.044 12.8 0.1 6.3 5.8 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein Roc PF08477.13 ORX44614.1 - 0.052 13.8 1.4 9.1 6.5 0.0 3.2 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 ORX44614.1 - 0.081 12.1 0.6 1.9 7.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TEX13 PF15186.6 ORX44614.1 - 0.11 12.1 1.9 0.13 11.9 0.1 1.9 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family AAA_23 PF13476.6 ORX44614.1 - 0.14 12.6 1.3 14 6.1 0.0 2.9 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 ORX44614.1 - 0.16 11.7 0.9 22 4.7 0.0 2.8 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX44614.1 - 0.35 10.6 2.0 15 5.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX44614.1 - 0.36 10.7 3.2 19 5.1 0.0 3.0 3 0 0 3 3 2 0 NACHT domain NB-ARC PF00931.22 ORX44614.1 - 0.53 9.4 3.0 6.6 5.8 0.5 2.5 2 1 0 2 2 2 0 NB-ARC domain Velvet PF11754.8 ORX44616.1 - 1.3e-56 192.4 8.3 7.7e-38 130.9 0.2 2.8 2 1 1 3 3 3 2 Velvet factor RasGEF PF00617.19 ORX44617.1 - 3e-57 193.7 2.4 3e-57 193.7 2.4 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ORX44617.1 - 5.1e-26 91.0 0.8 1.5e-25 89.5 0.4 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 ORX44617.1 - 7.5e-15 54.3 0.2 1.4e-14 53.4 0.2 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX44617.1 - 9.2e-13 47.8 0.2 2e-12 46.8 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX44617.1 - 6.5e-11 41.8 0.1 1.4e-10 40.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 ORX44617.1 - 1.9e-09 37.4 7.6 3.8e-07 30.1 0.1 3.0 3 0 0 3 3 3 2 WW domain CAS_C PF12026.8 ORX44617.1 - 0.0069 16.5 0.5 0.024 14.7 0.5 1.9 1 0 0 1 1 1 1 Crk-Associated Substrate C-terminal domain CTP_transf_1 PF01148.20 ORX44618.1 - 4.2e-79 266.1 22.5 5.7e-79 265.6 22.5 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family zf-Mss51 PF13824.6 ORX44619.1 - 3.2e-18 65.6 14.9 6e-18 64.7 14.9 1.5 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 OrfB_Zn_ribbon PF07282.11 ORX44619.1 - 2 8.4 4.4 5.8 6.9 4.4 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-MYND PF01753.18 ORX44619.1 - 8.1 6.6 10.2 13 5.9 10.2 1.4 1 0 0 1 1 1 0 MYND finger SH3_1 PF00018.28 ORX44620.1 - 7.8e-07 28.6 0.0 1.2e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX44620.1 - 0.00062 19.4 0.0 0.00096 18.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX44620.1 - 0.0041 16.9 0.0 0.0068 16.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain RNase_PH PF01138.21 ORX44743.1 - 6.4e-22 78.5 0.0 9.3e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX44743.1 - 2.1e-06 27.7 0.0 3.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 CLASP_N PF12348.8 ORX44744.1 - 7.2e-42 143.5 0.1 7.2e-42 143.5 0.1 2.1 3 0 0 3 3 3 1 CLASP N terminal HEAT PF02985.22 ORX44744.1 - 8.6e-06 25.6 0.4 0.11 12.8 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 ORX44744.1 - 0.0017 18.7 0.2 1.6 9.2 0.0 4.1 3 0 0 3 3 3 1 HEAT repeats GGDEF_2 PF17853.1 ORX44744.1 - 0.0058 16.9 3.7 0.018 15.3 0.2 3.3 4 0 0 4 4 4 1 GGDEF-like domain WD40 PF00400.32 ORX44745.1 - 1.5e-06 28.8 5.7 0.025 15.4 0.0 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Mcl1_mid PF12341.8 ORX44745.1 - 0.038 13.3 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 ORX44745.1 - 0.1 12.9 0.0 4.9 7.5 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX44745.1 - 0.13 11.2 0.0 0.56 9.1 0.0 1.9 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Zn_clus PF00172.18 ORX44747.1 - 0.0028 17.8 6.9 0.0068 16.5 6.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-RRN7 PF11781.8 ORX44747.1 - 2.2 8.0 4.9 8 6.2 4.9 1.9 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF1735 PF08522.10 ORX44747.1 - 3.8 8.1 4.4 45 4.7 0.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1735) Y_phosphatase PF00102.27 ORX44748.1 - 2.2e-64 217.2 0.0 2.8e-64 216.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ORX44748.1 - 0.0012 18.8 0.0 0.0017 18.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ORX44748.1 - 0.0026 17.9 0.0 0.0044 17.1 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate DSPc PF00782.20 ORX44748.1 - 0.019 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Pkinase PF00069.25 ORX44749.1 - 1.2e-53 182.1 0.0 2.3e-38 132.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44749.1 - 1.4e-20 73.7 0.0 4.4e-20 72.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX44749.1 - 9.9e-07 28.3 0.0 2.3e-06 27.1 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX44749.1 - 1.2e-05 24.8 0.1 1.9e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX44749.1 - 0.00018 21.6 0.0 0.00026 21.0 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX44749.1 - 0.00061 18.8 0.1 0.001 18.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ORX44749.1 - 0.012 15.3 0.2 0.035 13.7 0.1 1.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ORX44749.1 - 0.016 14.0 0.0 0.019 13.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase HA2 PF04408.23 ORX44750.1 - 3.6e-20 72.3 1.0 6.6e-20 71.4 0.0 2.0 2 0 0 2 2 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ORX44750.1 - 6.6e-16 58.6 0.0 2.8e-15 56.6 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ORX44750.1 - 2.6e-14 53.3 0.0 8.2e-14 51.7 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold RWD PF05773.22 ORX44750.1 - 1.7e-13 50.9 0.0 6.6e-13 49.0 0.0 2.1 1 0 0 1 1 1 1 RWD domain DEAD PF00270.29 ORX44750.1 - 8.1e-11 42.0 2.7 2.3e-10 40.5 1.4 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase UBA PF00627.31 ORX44750.1 - 2.6e-09 36.8 0.0 3.4e-07 30.0 0.0 2.6 2 0 0 2 2 2 1 UBA/TS-N domain CHCH PF06747.13 ORX44750.1 - 2.6e-07 30.6 4.3 6e-07 29.4 4.3 1.7 1 0 0 1 1 1 1 CHCH domain AAA_22 PF13401.6 ORX44750.1 - 7.9e-05 23.0 0.2 0.00026 21.3 0.2 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX44750.1 - 0.00043 20.6 0.2 0.00043 20.6 0.2 2.3 2 1 0 2 2 2 1 AAA domain GCK PF07802.11 ORX44750.1 - 0.0041 17.5 2.0 0.013 15.9 2.0 1.9 1 0 0 1 1 1 1 GCK domain T2SSE PF00437.20 ORX44750.1 - 0.0075 15.4 0.0 0.019 14.1 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 ORX44750.1 - 0.033 13.6 0.3 0.09 12.2 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 ORX44750.1 - 0.043 13.5 0.1 0.17 11.6 0.1 2.0 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ORX44750.1 - 0.072 12.4 0.0 0.15 11.3 0.0 1.5 1 0 0 1 1 1 0 KaiC Ecl1 PF12855.7 ORX44751.1 - 7e-10 40.3 8.6 8.4e-10 40.1 8.6 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 ORX44751.1 - 0.031 14.3 3.3 0.091 12.9 3.3 1.8 1 0 0 1 1 1 0 MYND finger Galactosyl_T PF01762.21 ORX44752.1 - 5.6e-09 36.1 0.9 1.8e-07 31.2 0.5 2.3 1 1 1 2 2 2 2 Galactosyltransferase Torsin PF06309.11 ORX44752.1 - 0.09 12.9 0.2 0.29 11.2 0.0 1.9 2 1 1 3 3 3 0 Torsin CNOT11 PF10155.9 ORX44754.1 - 2.7e-20 72.8 0.3 4.1e-20 72.2 0.3 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 Ins_allergen_rp PF06757.13 ORX44754.1 - 0.07 13.1 0.3 0.14 12.1 0.1 1.6 2 0 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification zf-Tim10_DDP PF02953.15 ORX44755.1 - 8.1e-25 86.3 0.4 1.4e-24 85.5 0.4 1.4 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF3398 PF11878.8 ORX44755.1 - 0.072 13.5 0.2 0.085 13.3 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) Sybindin PF04099.12 ORX44756.1 - 1.3e-25 90.0 0.6 9.5e-25 87.2 0.6 2.0 1 1 0 1 1 1 1 Sybindin-like family Zn_clus PF00172.18 ORX44757.1 - 2.7e-07 30.6 8.2 5.1e-07 29.7 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain She9_MDM33 PF05546.11 ORX44757.1 - 0.047 13.5 0.8 0.076 12.8 0.8 1.2 1 0 0 1 1 1 0 She9 / Mdm33 family Arf PF00025.21 ORX44758.1 - 4e-79 264.1 0.0 4.6e-79 263.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX44758.1 - 4.7e-14 52.6 0.0 6.5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ORX44758.1 - 2.8e-13 49.8 1.3 2e-09 37.1 0.2 2.2 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX44758.1 - 7.9e-13 48.2 0.0 9.9e-13 47.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX44758.1 - 2.1e-12 46.9 0.0 2.3e-12 46.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ORX44758.1 - 5.8e-10 38.9 0.0 7.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX44758.1 - 4.9e-06 26.6 0.0 7.4e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ORX44758.1 - 0.0056 16.0 0.6 0.014 14.7 0.6 1.8 1 1 0 1 1 1 1 6-phosphofructo-2-kinase TPR_2 PF07719.17 ORX44759.1 - 8.2e-14 50.5 15.3 0.0014 18.6 0.3 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX44759.1 - 1.3e-12 47.0 13.2 0.0021 17.8 0.3 8.1 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX44759.1 - 2.1e-12 46.8 13.2 0.23 12.4 1.3 8.5 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX44759.1 - 2.1e-11 43.1 8.7 0.38 11.1 0.2 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX44759.1 - 1.3e-09 38.5 14.6 0.0027 18.2 0.1 7.3 8 2 1 9 9 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX44759.1 - 7e-07 28.8 8.2 0.59 9.9 0.0 6.7 7 0 0 7 7 7 2 TPR repeat TPR_17 PF13431.6 ORX44759.1 - 1.2e-06 28.4 2.9 0.47 11.0 0.0 6.9 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX44759.1 - 2.5e-06 27.1 4.4 0.018 15.1 0.0 5.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX44759.1 - 5.6e-06 26.9 13.8 0.0038 17.8 0.3 6.6 6 2 1 7 7 7 2 Tetratricopeptide repeat TPR_20 PF14561.6 ORX44759.1 - 0.0004 20.6 1.0 5.4 7.4 0.0 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX44759.1 - 0.00042 20.5 6.4 5.5 7.3 0.0 5.5 6 0 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ORX44759.1 - 0.0072 16.9 14.2 1.1 10.0 0.1 6.9 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX44759.1 - 0.028 14.6 12.6 12 6.1 0.0 5.9 6 1 1 7 7 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX44759.1 - 0.18 11.9 2.6 2.5 8.2 1.5 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 ORX44759.1 - 0.78 10.5 3.4 8.3 7.4 0.0 4.8 6 0 0 6 6 3 0 Tetratricopeptide repeat MFS_1 PF07690.16 ORX44760.1 - 1.4e-39 136.0 25.8 1.4e-39 136.0 25.8 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Pga1 PF10333.9 ORX44761.1 - 0.087 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 GPI-Mannosyltransferase II co-activator zf-C2H2_2 PF12756.7 ORX44762.1 - 0.0006 20.1 6.5 0.34 11.3 0.1 3.4 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX44762.1 - 0.022 15.6 13.4 0.11 13.4 2.0 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX44762.1 - 0.024 15.1 10.3 0.12 12.9 1.9 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type Rpr2 PF04032.16 ORX44762.1 - 0.061 13.6 0.4 0.31 11.4 0.4 2.1 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-BED PF02892.15 ORX44762.1 - 0.074 13.1 1.5 0.14 12.2 0.3 2.2 2 0 0 2 2 2 0 BED zinc finger DUF629 PF04780.12 ORX44762.1 - 0.11 11.0 2.9 4.6 5.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF629) GAGA PF09237.11 ORX44762.1 - 1.7 8.5 3.9 0.85 9.5 1.0 2.0 2 0 0 2 2 2 0 GAGA factor zf-Di19 PF05605.12 ORX44762.1 - 8.1 6.8 8.6 5.9 7.3 0.5 2.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding F-box PF00646.33 ORX44763.1 - 0.0029 17.4 3.3 0.012 15.5 0.5 3.1 4 0 0 4 4 4 1 F-box domain PRANC PF09372.10 ORX44763.1 - 0.0064 16.8 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 PRANC domain FYRC PF05965.14 ORX44763.1 - 0.18 11.9 0.0 0.45 10.7 0.0 1.6 1 0 0 1 1 1 0 F/Y rich C-terminus F-box-like PF12937.7 ORX44764.1 - 0.075 12.9 0.3 0.24 11.3 0.3 2.0 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 ORX44764.1 - 1.7 9.2 7.6 28 5.3 1.0 4.8 6 0 0 6 6 6 0 Leucine Rich repeats (2 copies) Myb_DNA-binding PF00249.31 ORX44765.1 - 1.5e-40 137.1 12.3 6.4e-15 55.1 0.2 3.1 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX44765.1 - 2.4e-33 114.1 4.2 2.3e-14 53.4 0.0 3.1 1 1 2 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 ORX44765.1 - 9.1e-07 29.2 10.7 0.022 15.1 0.2 4.1 3 2 0 3 3 3 3 Myb/SANT-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX44765.1 - 6.2e-06 26.0 0.1 0.037 13.9 0.0 3.0 2 1 2 4 4 4 2 Myb DNA-binding like SLIDE PF09111.10 ORX44765.1 - 5.2e-05 23.2 0.0 0.017 15.1 0.0 3.0 1 1 2 3 3 3 1 SLIDE Myb_DNA-bind_5 PF13873.6 ORX44765.1 - 0.017 15.2 6.3 19 5.4 0.0 4.4 2 1 2 4 4 4 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 ORX44765.1 - 0.026 14.8 7.1 1.3 9.4 1.2 3.2 2 1 1 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_2 PF08914.11 ORX44765.1 - 0.07 13.3 0.0 10 6.4 0.0 2.4 2 0 0 2 2 2 0 Rap1 Myb domain Glyco_transf_49 PF13896.6 ORX44766.1 - 2.1e-17 63.5 0.3 1.5e-15 57.4 0.1 2.3 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan PH PF00169.29 ORX44768.1 - 3.2e-07 30.8 0.1 6.9e-07 29.7 0.1 1.6 1 0 0 1 1 1 1 PH domain Baculo_PEP_C PF04513.12 ORX44768.1 - 0.15 12.1 0.3 0.39 10.8 0.1 1.7 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CdvA PF18822.1 ORX44768.1 - 0.26 11.1 2.6 0.36 10.6 0.1 2.4 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Glyco_hydro_35 PF01301.19 ORX44769.1 - 4.5e-55 187.5 2.4 4.2e-53 181.0 2.4 2.3 1 1 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 ORX44769.1 - 3e-12 47.1 0.4 2.7e-06 27.9 0.1 2.7 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain Glyco_hydro_42 PF02449.15 ORX44769.1 - 1.4e-05 24.6 0.0 0.00015 21.2 0.0 2.1 1 1 1 2 2 2 1 Beta-galactosidase Cellulase PF00150.18 ORX44769.1 - 0.00064 19.2 0.0 0.0013 18.2 0.0 1.4 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) GPI-anchored PF10342.9 ORX44770.1 - 1.4e-11 45.0 0.0 2.1e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family NPCBM_assoc PF10633.9 ORX44770.1 - 0.00031 21.0 2.5 0.00086 19.5 0.1 2.5 3 0 0 3 3 3 1 NPCBM-associated, NEW3 domain of alpha-galactosidase Big_7 PF17957.1 ORX44770.1 - 0.035 14.9 1.4 0.052 14.3 0.1 2.1 2 2 0 2 2 2 0 Bacterial Ig domain SIP PF04954.13 ORX44770.1 - 0.11 13.0 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Siderophore-interacting protein TFIIB PF00382.19 ORX44771.1 - 4.3e-44 148.4 1.4 4.1e-24 84.4 0.5 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ORX44771.1 - 1.5e-14 53.2 0.6 2.5e-14 52.5 0.6 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 ORX44771.1 - 0.0016 18.5 0.0 0.14 12.3 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain RB_B PF01857.20 ORX44771.1 - 0.0025 17.8 0.7 0.0049 16.9 0.4 1.5 1 1 0 1 1 1 1 Retinoblastoma-associated protein B domain Cyclin_N PF00134.23 ORX44771.1 - 0.013 15.3 1.0 0.27 11.0 0.3 2.2 1 1 1 2 2 2 0 Cyclin, N-terminal domain ORC6 PF05460.13 ORX44771.1 - 0.095 12.0 0.3 0.17 11.1 0.2 1.4 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) GDP_Man_Dehyd PF16363.5 ORX44772.1 - 5.3e-161 535.6 0.0 6e-161 535.4 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX44772.1 - 8.3e-76 254.6 0.0 1.1e-75 254.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ORX44772.1 - 5e-08 32.4 0.0 7.3e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ORX44772.1 - 0.00016 20.9 0.0 0.00026 20.2 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 ORX44772.1 - 0.00029 20.5 0.0 0.00046 19.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ORX44772.1 - 0.062 12.7 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase zf-C3HC4_2 PF13923.6 ORX44773.1 - 3.6e-12 45.9 8.3 6.6e-12 45.1 8.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX44773.1 - 8.2e-12 45.3 8.8 1.5e-11 44.4 8.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX44773.1 - 1.1e-09 37.9 2.1 2.3e-09 36.9 2.1 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX44773.1 - 2e-08 33.9 8.6 3.8e-08 33.1 8.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX44773.1 - 2.6e-07 30.6 6.8 5.5e-07 29.5 6.8 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX44773.1 - 3.8e-07 30.3 13.6 7.2e-07 29.4 11.1 2.3 2 1 0 2 2 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ORX44773.1 - 6.6e-06 25.9 7.7 6.6e-06 25.9 7.7 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX44773.1 - 0.00031 20.7 3.0 0.00059 19.8 3.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ORX44773.1 - 0.00038 20.3 8.1 0.00038 20.3 8.1 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ORX44773.1 - 0.0007 19.7 7.4 0.0014 18.7 7.4 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 ORX44773.1 - 0.0012 18.4 8.0 0.0021 17.7 8.0 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type DUF4763 PF15960.5 ORX44773.1 - 0.0014 18.0 5.2 0.0021 17.4 5.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) zf-Nse PF11789.8 ORX44773.1 - 0.0017 18.1 3.1 0.0028 17.4 3.1 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3H2C3 PF17122.5 ORX44773.1 - 0.0043 17.0 6.5 0.01 15.9 6.5 1.7 1 1 0 1 1 1 1 Zinc-finger zf-RING_6 PF14835.6 ORX44773.1 - 0.0073 16.2 3.2 0.014 15.2 3.2 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 ORX44773.1 - 0.024 14.5 9.6 0.056 13.3 9.6 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 EMP24_GP25L PF01105.24 ORX44773.1 - 0.054 13.4 0.6 0.065 13.2 0.6 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DinB PF05163.12 ORX44773.1 - 0.067 13.1 0.7 0.2 11.6 0.7 1.7 1 1 0 1 1 1 0 DinB family Spc24 PF08286.11 ORX44773.1 - 0.11 12.7 1.6 0.19 12.0 1.6 1.4 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 GrpE PF01025.19 ORX44773.1 - 0.31 10.7 3.3 0.43 10.2 3.3 1.1 1 0 0 1 1 1 0 GrpE ZapB PF06005.12 ORX44773.1 - 0.38 11.2 5.9 0.82 10.2 5.9 1.5 1 0 0 1 1 1 0 Cell division protein ZapB ATP-synt_B PF00430.18 ORX44773.1 - 0.41 10.7 4.2 0.56 10.3 4.2 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) DUF3450 PF11932.8 ORX44773.1 - 1.7 7.9 7.8 2.4 7.4 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FANCL_C PF11793.8 ORX44773.1 - 5.5 7.2 11.9 65 3.8 11.9 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain YCII PF03795.14 ORX44774.1 - 9.1e-10 38.8 0.0 1.2e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain ESCRT-II PF05871.12 ORX44775.1 - 9.1e-50 168.5 1.8 1.1e-49 168.3 1.8 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit SelB-wing_2 PF09106.11 ORX44775.1 - 0.017 15.3 0.1 6.1 7.1 0.0 2.7 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Histone PF00125.24 ORX44776.1 - 6.8e-24 84.7 0.8 8.9e-24 84.3 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX44776.1 - 1.2e-06 28.7 0.1 2.9e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ORX44776.1 - 0.00014 22.3 0.0 0.00025 21.5 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 ORX44776.1 - 0.014 15.4 0.3 0.016 15.2 0.3 1.1 1 0 0 1 1 1 0 YscO-like protein DUF1018 PF06252.12 ORX44776.1 - 0.016 16.2 0.4 0.021 15.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) CENP-W PF15510.6 ORX44776.1 - 0.038 14.2 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein RP-C PF03428.13 ORX44776.1 - 0.043 13.5 0.6 3.5 7.3 0.0 1.9 1 1 1 2 2 2 0 Replication protein C N-terminal domain DUF3915 PF13054.6 ORX44776.1 - 0.16 12.0 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Histone_H2A_C PF16211.5 ORX44777.1 - 1.1e-20 73.0 1.4 2e-20 72.2 1.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ORX44777.1 - 6.5e-18 65.4 0.0 8.4e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX44777.1 - 0.0008 19.6 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 ORX44778.1 - 2.6e-08 33.9 0.1 3.2e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX44778.1 - 6e-05 23.1 0.1 8.6e-05 22.6 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ORX44778.1 - 9.6e-05 22.7 0.1 0.00013 22.3 0.1 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ORX44778.1 - 0.0002 21.7 0.2 0.00023 21.6 0.2 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX44778.1 - 0.00035 20.8 0.1 0.00068 19.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX44778.1 - 0.02 14.9 0.0 0.023 14.8 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX44778.1 - 0.059 13.4 0.0 0.091 12.8 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 ORX44778.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 ORX44779.1 - 8.6e-53 178.2 2.6 9.5e-53 178.0 2.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX44779.1 - 2.3e-05 24.7 0.0 3.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX44779.1 - 2.6e-05 24.3 0.5 4.8e-05 23.4 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ORX44779.1 - 5.5e-05 23.8 1.2 6.6e-05 23.5 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ORX44779.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX44779.1 - 0.059 13.5 0.1 0.094 12.8 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX44779.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated DEAD PF00270.29 ORX44780.1 - 2.6e-22 79.4 0.0 5.5e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX44780.1 - 1.3e-20 73.7 0.0 2.1e-18 66.7 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.10 ORX44780.1 - 2.2e-16 59.6 0.0 5e-16 58.5 0.0 1.6 1 0 0 1 1 1 1 RQC domain RecQ_Zn_bind PF16124.5 ORX44780.1 - 1.7e-15 57.5 6.2 1.7e-15 57.5 6.2 2.4 2 0 0 2 2 2 1 RecQ zinc-binding HRDC PF00570.23 ORX44780.1 - 1.2e-07 31.7 0.0 2.3e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 HRDC domain Helicase_Sgs1 PF11408.8 ORX44780.1 - 3.9e-06 26.8 0.0 8.7e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Sgs1 RecQ helicase ResIII PF04851.15 ORX44780.1 - 0.00084 19.4 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UBN_AB PF14075.6 ORX44780.1 - 0.088 12.5 0.8 0.22 11.2 0.1 2.0 2 0 0 2 2 2 0 Ubinuclein conserved middle domain QWRF PF04484.12 ORX44780.1 - 5.5 6.6 8.0 11 5.6 8.0 1.4 1 0 0 1 1 1 0 QWRF family MFS_1 PF07690.16 ORX44781.1 - 2.4e-43 148.4 68.6 1.3e-35 123.0 46.4 2.6 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX44781.1 - 1.6e-38 132.7 31.7 1.2e-36 126.5 31.7 2.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 ORX44781.1 - 0.067 12.0 19.0 0.054 12.3 2.5 2.6 1 1 1 2 2 2 0 MFS_1 like family F-box-like PF12937.7 ORX44782.1 - 0.31 11.0 2.7 1.5 8.7 0.7 3.2 3 0 0 3 3 3 0 F-box-like F-box-like PF12937.7 ORX44784.1 - 0.00016 21.5 1.0 0.00033 20.5 1.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX44784.1 - 0.0083 16.0 1.3 0.029 14.2 1.3 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX44785.1 - 6.4e-05 22.8 0.9 0.0003 20.6 0.2 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX44785.1 - 0.0015 18.4 1.0 0.012 15.5 0.1 2.5 2 0 0 2 2 2 1 F-box domain Ribosomal_L34e PF01199.18 ORX44787.1 - 1.5e-43 147.0 6.9 2.1e-43 146.6 6.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e PDGF PF00341.17 ORX44787.1 - 0.054 13.8 1.5 0.95 9.8 0.1 2.1 1 1 0 2 2 2 0 PDGF/VEGF domain RBFA PF02033.18 ORX44788.1 - 1.9e-12 47.6 0.3 2.8e-12 47.0 0.3 1.3 1 0 0 1 1 1 1 Ribosome-binding factor A ALIX_LYPXL_bnd PF13949.6 ORX44788.1 - 0.022 14.1 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Asp PF00026.23 ORX44789.1 - 8.3e-80 268.5 0.0 1.1e-79 268.2 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX44789.1 - 1.8e-11 44.6 0.0 5.9e-11 42.9 0.0 1.9 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX44789.1 - 1.7e-06 27.9 0.0 7.4e-06 25.8 0.0 2.0 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 ORX44789.1 - 0.00023 21.7 0.2 3.1 8.5 0.0 3.5 2 2 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX44789.1 - 0.0056 17.2 0.1 4.2 8.0 0.0 3.2 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease Glyco_trans_2_3 PF13632.6 ORX44790.1 - 1.4e-14 54.5 0.3 1.4e-14 54.5 0.3 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Rhodanese PF00581.20 ORX44791.1 - 4e-10 40.1 0.0 6.3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain Peptidase_M24 PF00557.24 ORX44792.1 - 1.7e-25 89.9 0.1 2.7e-25 89.3 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 FAA_hydro_N_2 PF18288.1 ORX44792.1 - 0.039 14.4 0.6 0.2 12.1 0.2 2.4 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 RSN1_7TM PF02714.15 ORX44793.1 - 7.2e-70 235.4 26.8 1.8e-69 234.1 26.8 1.7 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX44793.1 - 2.7e-28 98.7 4.5 2.7e-28 98.7 4.5 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX44793.1 - 6.3e-28 98.2 0.0 1e-27 97.5 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Aminotran_4 PF01063.19 ORX44794.1 - 6.9e-18 65.3 0.0 8.7e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV VP9 PF09625.10 ORX44794.1 - 0.06 13.5 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 VP9 protein Zn_clus PF00172.18 ORX44795.1 - 0.11 12.7 2.4 0.19 11.8 2.4 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF104 PF01954.16 ORX44795.1 - 0.14 12.6 0.1 0.3 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF104 ING PF12998.7 ORX44796.1 - 8.4e-20 71.3 1.1 8.4e-20 71.3 1.1 2.0 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX44796.1 - 1.1e-05 25.2 8.6 2e-05 24.4 8.6 1.4 1 0 0 1 1 1 1 PHD-finger DUF4407 PF14362.6 ORX44796.1 - 0.00045 19.7 6.4 0.00059 19.3 6.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) NPR3 PF03666.13 ORX44796.1 - 0.0064 15.3 3.3 0.0064 15.3 3.3 1.4 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Pns11_12 PF17464.2 ORX44796.1 - 0.01 15.5 8.6 0.016 14.9 8.6 1.3 1 0 0 1 1 1 0 Non-structural protein 11 and 12 MMU163 PF17119.5 ORX44796.1 - 0.022 13.9 1.2 0.031 13.4 1.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis zf-HC5HC2H PF13771.6 ORX44796.1 - 0.12 12.7 3.5 0.42 10.9 3.2 2.1 1 1 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 ORX44796.1 - 0.14 11.8 2.2 0.28 10.8 2.2 1.6 1 0 0 1 1 1 0 PHD-finger RNA_pol_Rpc4 PF05132.14 ORX44796.1 - 0.15 12.5 4.0 0.22 11.9 4.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDRT4 PF15213.6 ORX44796.1 - 0.9 10.2 4.2 0.39 11.3 1.5 1.7 2 0 0 2 2 2 0 CMT1A duplicated region transcript 4 protein Presenilin PF01080.17 ORX44796.1 - 1.7 7.3 3.2 2.3 6.9 3.2 1.1 1 0 0 1 1 1 0 Presenilin OrfB_Zn_ribbon PF07282.11 ORX44797.1 - 4.9e-08 32.8 0.1 1.4e-07 31.3 0.1 1.8 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX44797.1 - 0.0072 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease EcoRII, N-terminal Cdc6_C PF09079.11 ORX44797.1 - 0.17 11.9 0.1 2.5 8.1 0.1 2.6 2 1 0 2 2 2 0 CDC6, C terminal winged helix domain SDA1 PF05285.12 ORX44797.1 - 0.42 10.0 7.6 0.6 9.5 7.6 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_A_exo1 PF01612.20 ORX44798.1 - 8e-49 165.7 3.5 1.4e-48 164.9 3.5 1.4 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 ORX44798.1 - 2.6e-18 66.5 0.8 1.7e-17 63.9 0.8 2.5 1 0 0 1 1 1 1 PMC2NT (NUC016) domain HRDC PF00570.23 ORX44798.1 - 4.7e-13 48.9 0.0 2.7e-12 46.5 0.0 2.2 2 0 0 2 2 2 1 HRDC domain OrfB_Zn_ribbon PF07282.11 ORX44800.1 - 2e-05 24.4 4.2 2e-05 24.4 4.2 3.0 2 1 0 2 2 2 1 Putative transposase DNA-binding domain DUF4446 PF14584.6 ORX44898.1 - 0.022 14.8 0.2 1.7 8.6 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF601 PF04642.12 ORX44898.1 - 0.029 13.9 0.4 0.031 13.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF601 SMC_hinge PF06470.13 ORX44898.1 - 0.053 13.8 0.1 0.075 13.3 0.1 1.2 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Connexin50 PF03509.14 ORX44898.1 - 0.06 14.1 0.0 0.1 13.4 0.0 1.3 1 0 0 1 1 1 0 Gap junction alpha-8 protein (Cx50) IFT20 PF14931.6 ORX44898.1 - 0.074 13.2 2.4 0.099 12.8 2.4 1.2 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 LUC7 PF03194.15 ORX44898.1 - 0.089 12.4 2.0 0.99 9.0 0.0 2.0 1 1 1 2 2 2 0 LUC7 N_terminus BLOC1_2 PF10046.9 ORX44898.1 - 0.11 12.9 0.5 0.38 11.1 0.5 1.9 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FliJ PF02050.16 ORX44898.1 - 0.96 9.7 9.8 1.1 9.5 3.5 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein Ribosomal_S27 PF01599.19 ORX44899.1 - 0.00011 22.3 0.0 11 6.2 0.0 3.6 4 0 0 4 4 4 3 Ribosomal protein S27a Myelin-PO_C PF10570.9 ORX44899.1 - 0.015 15.7 0.0 44 4.6 0.0 3.1 3 0 0 3 3 3 0 Myelin-PO cytoplasmic C-term p65 binding region MAR_sialic_bdg PF10564.9 ORX44899.1 - 0.094 12.8 0.1 16 5.6 0.0 2.3 2 0 0 2 2 2 0 Sialic-acid binding micronemal adhesive repeat Cupin_8 PF13621.6 ORX44900.1 - 6.2e-40 137.5 0.7 8.6e-40 137.1 0.7 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ORX44900.1 - 2.4e-13 50.2 1.1 4.3e-13 49.4 1.1 1.4 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ORX44900.1 - 0.00018 21.9 0.0 0.00035 21.0 0.0 1.5 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 ORX44900.1 - 0.0036 17.0 0.0 0.0086 15.8 0.0 1.6 1 0 0 1 1 1 1 Cupin domain F-box-like PF12937.7 ORX44902.1 - 3.7e-06 26.7 0.5 1.2e-05 25.1 0.5 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX44902.1 - 0.00041 20.1 0.1 0.0036 17.1 0.0 2.7 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX44903.1 - 3.4e-08 33.3 1.3 1.3e-07 31.4 1.3 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX44903.1 - 0.00095 19.0 0.4 0.0029 17.4 0.4 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX44906.1 - 7.1e-10 38.6 0.2 2e-09 37.2 0.2 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX44906.1 - 3.3e-05 23.6 0.0 0.00018 21.3 0.0 2.4 1 0 0 1 1 1 1 F-box domain Cupin_8 PF13621.6 ORX44910.1 - 1.1e-40 140.0 0.7 1.7e-40 139.4 0.7 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ORX44910.1 - 3.3e-13 49.8 1.4 5.6e-13 49.0 1.4 1.3 1 0 0 1 1 1 1 Cupin superfamily protein JmjC PF02373.22 ORX44910.1 - 0.00067 20.1 0.0 0.0013 19.2 0.0 1.6 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 ORX44910.1 - 0.0066 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Cupin domain Ribosomal_L7Ae PF01248.26 ORX44912.1 - 5.4e-27 93.4 2.2 6.9e-27 93.0 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_L23eN PF03939.13 ORX44913.1 - 6e-22 77.6 11.1 6e-22 77.6 11.1 1.9 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ORX44913.1 - 1.8e-16 60.2 8.6 6.2e-16 58.6 3.4 2.8 2 1 0 2 2 2 1 Ribosomal protein L23 Linker_histone PF00538.19 ORX44913.1 - 0.41 11.0 3.4 0.89 10.0 0.3 2.2 2 0 0 2 2 2 0 linker histone H1 and H5 family PAC4 PF16093.5 ORX44914.1 - 1.8e-19 69.7 0.1 2.4e-19 69.3 0.1 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 GAGA PF09237.11 ORX44914.1 - 0.013 15.3 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 GAGA factor Pkinase PF00069.25 ORX44915.1 - 2.6e-70 236.8 0.0 3.5e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44915.1 - 3.8e-54 183.7 0.0 5.2e-54 183.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ORX44915.1 - 0.00022 21.0 6.7 0.00022 21.0 6.7 1.8 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 ORX44915.1 - 0.0034 16.7 0.0 0.085 12.2 0.0 2.1 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX44915.1 - 0.007 15.2 0.3 0.016 14.0 0.3 1.6 1 1 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ORX44915.1 - 0.014 15.0 0.0 0.041 13.5 0.0 1.5 1 1 1 2 2 2 0 RIO1 family Zn_ribbon_17 PF17120.5 ORX44915.1 - 0.057 13.0 6.4 0.16 11.6 6.4 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DZR PF12773.7 ORX44915.1 - 1.9 8.6 8.9 2.1 8.5 7.5 1.8 1 1 0 1 1 1 0 Double zinc ribbon adh_short PF00106.25 ORX44916.1 - 4.1e-26 91.6 0.0 4.7e-25 88.2 0.0 2.1 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX44916.1 - 2.3e-15 56.8 0.0 1.2e-14 54.4 0.0 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX44916.1 - 9.3e-06 25.7 0.0 1.7e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX44916.1 - 0.0001 21.9 0.0 0.0002 20.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Spore_YhaL PF14147.6 ORX44916.1 - 0.13 11.9 0.1 0.3 10.8 0.1 1.6 1 0 0 1 1 1 0 Sporulation protein YhaL Atg14 PF10186.9 ORX44917.1 - 0.00042 19.5 10.0 0.00073 18.7 10.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_PEP_C PF04513.12 ORX44917.1 - 0.015 15.3 0.8 2.4 8.2 0.4 2.4 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2730 PF10805.8 ORX44917.1 - 0.19 11.8 0.2 0.19 11.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Peptidase_S49_N PF08496.10 ORX44917.1 - 0.37 10.8 4.7 0.68 10.0 4.7 1.6 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FapA PF03961.13 ORX44917.1 - 1.3 7.6 4.1 1.7 7.1 4.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A ALMT PF11744.8 ORX44917.1 - 8.7 5.0 8.0 11 4.7 8.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ank_4 PF13637.6 ORX44918.1 - 2.3e-18 66.3 1.5 1.7e-10 41.2 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX44918.1 - 5.1e-13 49.4 0.5 7.3e-05 23.3 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 ORX44918.1 - 4.2e-10 39.6 0.0 0.00047 20.5 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ORX44918.1 - 2.5e-08 33.5 0.2 0.04 14.5 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ORX44918.1 - 6.1e-07 29.6 3.1 0.012 15.9 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeats (many copies) KilA-N PF04383.13 ORX44918.1 - 3.2e-06 26.9 0.6 4e-05 23.4 0.3 2.6 2 1 0 2 2 2 1 KilA-N domain SCP2_2 PF13530.6 ORX44918.1 - 0.092 13.2 0.4 0.19 12.1 0.4 1.5 1 0 0 1 1 1 0 Sterol carrier protein domain NCOA_u2 PF16665.5 ORX44918.1 - 0.11 12.9 1.5 0.32 11.3 0.1 2.3 2 0 0 2 2 2 0 Unstructured region on nuclear receptor coactivator protein RhoGEF PF00621.20 ORX44919.1 - 1.2e-28 100.6 2.5 2e-28 99.9 2.5 1.3 1 0 0 1 1 1 1 RhoGEF domain Pkinase PF00069.25 ORX44920.1 - 5.9e-75 252.0 0.0 7.2e-75 251.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44920.1 - 1e-35 123.3 0.0 1.3e-35 123.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX44920.1 - 1.5e-07 31.0 0.0 9e-07 28.5 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 ORX44920.1 - 0.012 16.2 1.2 0.036 14.8 1.2 1.7 1 0 0 1 1 1 0 Protein kinase C terminal domain Kdo PF06293.14 ORX44920.1 - 0.088 12.1 0.0 0.18 11.1 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX44920.1 - 0.13 11.1 0.1 0.24 10.3 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Lipase_GDSL PF00657.22 ORX44922.1 - 6.7e-10 39.3 0.0 1.8e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX44922.1 - 7.5e-05 23.2 1.0 0.0034 17.8 0.1 2.4 2 1 0 2 2 2 2 GDSL-like Lipase/Acylhydrolase family Methyltransf_16 PF10294.9 ORX44923.1 - 5.2e-35 120.7 0.0 6.6e-35 120.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ORX44923.1 - 3.7e-06 26.9 0.0 6.1e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX44923.1 - 0.00023 20.8 0.0 0.00037 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ORX44923.1 - 0.0014 19.3 0.0 0.0024 18.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ORX44923.1 - 0.0082 15.9 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 ORX44923.1 - 0.01 15.5 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PrmA PF06325.13 ORX44923.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) TMEM234 PF10639.9 ORX44924.1 - 6.6e-40 135.8 0.5 7.5e-40 135.6 0.5 1.0 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 ORX44924.1 - 7.5e-07 29.4 3.0 0.00028 21.1 1.3 2.0 2 0 0 2 2 2 2 EamA-like transporter family NMN_transporter PF04973.12 ORX44924.1 - 0.012 15.6 0.6 0.016 15.2 0.6 1.5 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter Rhv PF00073.20 ORX44924.1 - 0.16 11.6 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 picornavirus capsid protein RseC_MucC PF04246.12 ORX44924.1 - 1.8 8.6 4.0 1.3 9.0 0.3 2.3 2 1 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC LEA_2 PF03168.13 ORX44925.1 - 7.8e-06 26.4 0.0 9.9e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Late embryogenesis abundant protein Ribophorin_I PF04597.14 ORX44925.1 - 0.038 13.2 0.1 0.043 13.0 0.1 1.0 1 0 0 1 1 1 0 Ribophorin I Kinesin PF00225.23 ORX44926.1 - 9.6e-112 373.2 0.5 9.6e-112 373.2 0.5 2.4 3 1 1 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 ORX44926.1 - 5e-25 88.2 0.0 5e-25 88.2 0.0 2.9 3 0 0 3 3 3 1 Microtubule binding Spc7 PF08317.11 ORX44926.1 - 0.005 15.8 25.6 0.005 15.8 25.6 3.9 1 1 3 4 4 4 2 Spc7 kinetochore protein TFA2_Winged_2 PF18121.1 ORX44926.1 - 0.01 15.5 2.6 0.88 9.3 0.5 4.1 3 1 1 4 4 4 0 TFA2 Winged helix domain 2 EF-hand_7 PF13499.6 ORX44926.1 - 0.025 15.0 2.2 0.1 13.0 0.4 3.1 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_1 PF00036.32 ORX44926.1 - 0.045 13.3 0.0 0.22 11.2 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 ORX44926.1 - 0.15 12.1 0.0 1 9.5 0.0 2.5 2 0 0 2 2 2 0 EF-hand domain Filament PF00038.21 ORX44926.1 - 0.46 10.0 82.9 0.69 9.4 54.3 3.1 2 1 1 3 3 3 0 Intermediate filament protein Synaptobrevin PF00957.21 ORX44927.1 - 9.8e-15 54.1 0.3 1.6e-14 53.5 0.3 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ORX44927.1 - 4.6e-12 45.8 0.0 8.6e-12 44.9 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain EF_TS PF00889.19 ORX44927.1 - 0.039 13.6 0.0 0.64 9.6 0.0 2.0 2 0 0 2 2 2 0 Elongation factor TS Pkinase PF00069.25 ORX44928.1 - 9e-52 176.0 0.0 1.1e-51 175.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX44928.1 - 3.5e-33 115.0 0.0 4.5e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX44928.1 - 4e-05 23.1 0.6 7.4e-05 22.2 0.6 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX44928.1 - 0.059 13.0 0.1 0.21 11.2 0.1 1.9 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX44928.1 - 0.068 12.1 0.0 0.082 11.8 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 ORX44928.1 - 0.081 12.2 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ORX44928.1 - 0.13 12.2 1.3 0.17 11.8 0.4 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Cytidylate_kin PF02224.18 ORX44929.1 - 8.2e-59 198.9 1.4 1.3e-57 195.0 1.4 1.9 1 1 0 1 1 1 1 Cytidylate kinase Cytidylate_kin2 PF13189.6 ORX44929.1 - 1.1e-07 32.1 0.9 2.4e-06 27.8 0.9 2.3 1 1 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 ORX44929.1 - 2e-05 25.1 0.0 0.00015 22.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 ORX44929.1 - 0.0034 17.5 0.2 0.019 15.1 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase AAA_17 PF13207.6 ORX44929.1 - 0.0049 17.3 0.1 0.019 15.4 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX44929.1 - 0.0069 16.6 0.2 0.015 15.4 0.0 1.9 2 1 0 2 2 2 1 AAA domain dNK PF01712.19 ORX44929.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase CoaE PF01121.20 ORX44929.1 - 0.035 13.8 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 Dephospho-CoA kinase PRK PF00485.18 ORX44929.1 - 0.044 13.5 0.0 0.98 9.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family G-alpha PF00503.20 ORX44929.1 - 0.061 12.5 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_6 PF12774.7 ORX44929.1 - 0.074 12.0 0.0 0.14 11.1 0.0 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_28 PF13521.6 ORX44929.1 - 0.095 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain EF-hand_4 PF12763.7 ORX44930.1 - 5.2e-39 132.4 0.0 7.7e-18 64.4 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ORX44930.1 - 1e-09 37.2 0.1 0.28 10.8 0.0 5.4 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 ORX44930.1 - 2.5e-09 37.4 0.0 0.00081 19.8 0.2 3.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX44930.1 - 7.5e-06 25.5 2.2 12 6.1 0.0 5.8 6 0 0 6 6 5 0 EF-hand domain UBA PF00627.31 ORX44930.1 - 2.2e-05 24.3 0.0 4.9e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain EF-hand_8 PF13833.6 ORX44930.1 - 0.0026 17.6 0.0 0.58 10.1 0.0 3.9 4 1 0 4 4 4 1 EF-hand domain pair Myosin_tail_1 PF01576.19 ORX44930.1 - 0.028 12.2 26.9 0.038 11.8 26.9 1.0 1 0 0 1 1 1 0 Myosin tail EzrA PF06160.12 ORX44930.1 - 0.029 12.6 22.0 0.044 12.0 22.0 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Spc7 PF08317.11 ORX44930.1 - 0.1 11.5 32.7 0.017 14.1 24.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein AAA_13 PF13166.6 ORX44930.1 - 0.19 10.3 19.4 0.32 9.6 19.4 1.3 1 0 0 1 1 1 0 AAA domain GAS PF13851.6 ORX44930.1 - 0.2 11.0 35.5 1.4 8.2 7.1 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding AIP3 PF03915.13 ORX44930.1 - 0.36 9.9 24.1 0.5 9.4 24.1 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 zf-C4H2 PF10146.9 ORX44930.1 - 0.62 10.3 31.2 0.19 12.0 23.9 3.0 1 1 1 2 2 2 0 Zinc finger-containing protein THOC7 PF05615.13 ORX44930.1 - 0.93 9.8 31.1 6.2 7.1 17.7 2.9 1 1 1 2 2 2 0 Tho complex subunit 7 Laminin_I PF06008.14 ORX44930.1 - 1 9.0 31.8 2.9 7.5 16.4 2.4 1 1 1 2 2 2 0 Laminin Domain I DUF948 PF06103.11 ORX44930.1 - 1.2 9.5 16.5 0.024 14.9 2.6 2.9 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.15 ORX44930.1 - 1.6 8.6 20.9 0.94 9.3 6.0 2.4 2 0 0 2 2 2 0 Sec34-like family ERM PF00769.19 ORX44930.1 - 1.8 8.3 37.3 0.96 9.2 29.0 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Goodbye PF17109.5 ORX44930.1 - 2.5 8.6 10.5 0.32 11.4 2.3 2.6 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain TMF_TATA_bd PF12325.8 ORX44930.1 - 3.1 8.0 26.8 1.3 9.2 11.1 2.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 ORX44930.1 - 3.5 6.9 43.7 1.3 8.3 21.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Lebercilin PF15619.6 ORX44930.1 - 3.5 7.2 34.8 6.4 6.4 34.8 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 ORX44930.1 - 3.6 7.8 40.3 0.1 12.8 22.2 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) MscS_porin PF12795.7 ORX44930.1 - 3.7 7.0 54.3 0.91 9.0 34.8 2.2 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Sec8_exocyst PF04048.14 ORX44930.1 - 3.8 7.4 18.5 0.47 10.3 6.4 2.5 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF3584 PF12128.8 ORX44930.1 - 4.2 4.7 35.1 6.6 4.1 35.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Laminin_II PF06009.12 ORX44930.1 - 4.9 7.2 23.4 9.9 6.2 7.8 2.4 1 1 1 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 ORX44930.1 - 5 7.5 23.5 7.4 6.9 8.4 3.0 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF812 PF05667.11 ORX44930.1 - 9.7 4.9 31.4 14 4.4 30.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) RGS PF00615.19 ORX44931.1 - 1.1e-24 86.9 0.7 5.1e-24 84.8 0.2 2.3 3 0 0 3 3 3 1 Regulator of G protein signaling domain DEP PF00610.21 ORX44931.1 - 5.4e-11 42.4 0.1 0.00028 20.9 0.1 3.5 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PCI PF01399.27 ORX44932.1 - 1.2e-08 35.4 0.0 3.2e-08 34.0 0.0 1.8 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 ORX44932.1 - 0.35 11.1 1.8 1.4 9.2 1.8 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat CLP1_P PF16575.5 ORX44933.1 - 1.7e-49 168.2 0.2 3.7e-49 167.1 0.2 1.6 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 ORX44933.1 - 1.7e-33 115.5 0.0 3e-33 114.7 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 ORX44933.1 - 2e-33 114.5 0.0 4.4e-33 113.4 0.0 1.6 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor ATP_bind_1 PF03029.17 ORX44933.1 - 0.0078 16.0 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein SRP54 PF00448.22 ORX44933.1 - 0.011 15.3 0.0 0.03 14.0 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 ORX44933.1 - 0.012 15.4 0.0 0.017 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ORX44933.1 - 0.017 15.2 0.0 0.036 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 ORX44933.1 - 0.018 13.9 0.0 0.03 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 ORX44933.1 - 0.022 14.1 0.1 0.072 12.4 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_18 PF13238.6 ORX44933.1 - 0.028 14.9 0.0 0.065 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ORX44933.1 - 0.03 14.4 0.0 0.82 9.8 0.0 3.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ORX44933.1 - 0.089 13.0 0.1 0.33 11.2 0.0 2.0 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA PF00004.29 ORX44933.1 - 0.11 13.0 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ribosomal_L16 PF00252.18 ORX44934.1 - 1e-33 116.1 0.0 1.6e-32 112.3 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein L16p/L10e Defensin_beta PF00711.19 ORX44936.1 - 0.12 12.4 10.2 0.34 11.0 3.5 2.6 1 1 1 2 2 2 0 Beta defensin Choline_kinase PF01633.20 ORX44937.1 - 9.8e-57 192.0 0.0 1.6e-56 191.3 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ORX44937.1 - 3.3e-09 37.0 0.0 4.7e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family TBPIP PF07106.13 ORX44938.1 - 0.056 13.4 0.1 0.65 10.0 0.1 2.3 1 1 0 1 1 1 0 TBPIP/Hop2 winged helix domain DsrD PF08679.11 ORX44938.1 - 0.095 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Dissimilatory sulfite reductase D (DsrD) UvrD-helicase PF00580.21 ORX44939.1 - 4.1e-62 210.5 4.0 5e-61 206.9 1.7 2.7 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ORX44939.1 - 1.4e-34 119.5 0.0 2.8e-34 118.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain UvrD_C PF13361.6 ORX44939.1 - 5.2e-30 105.0 4.6 5.2e-30 105.0 4.6 1.9 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 ORX44939.1 - 8.3e-08 32.2 0.0 0.00098 18.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_11 PF13086.6 ORX44939.1 - 0.0021 17.9 0.1 0.005 16.7 0.1 1.6 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ORX44939.1 - 0.0074 16.0 0.1 1.3 8.7 0.0 2.3 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase 2-oxoacid_dh PF00198.23 ORX44940.1 - 5.4e-64 215.8 0.0 7.3e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX44940.1 - 2.3e-17 62.6 0.0 3.8e-17 61.9 0.0 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ORX44940.1 - 5.6e-10 39.4 0.0 1.3e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 e3 binding domain Novirhabdo_Nv PF05554.11 ORX44941.1 - 0.11 12.2 1.0 0.29 10.9 0.4 2.0 2 1 0 2 2 2 0 Viral hemorrhagic septicemia virus non-virion protein Exo_endo_phos_2 PF14529.6 ORX44942.1 - 0.037 13.9 0.0 0.072 12.9 0.0 1.6 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase DUF1163 PF06651.11 ORX44943.1 - 0.081 13.0 0.1 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) zf-C2H2_4 PF13894.6 ORX44943.1 - 0.6 11.1 13.2 4 8.5 4.5 3.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX44943.1 - 1.3 9.4 7.9 8.7 6.7 1.5 3.0 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) PIG-F PF06699.11 ORX44944.1 - 2.6e-34 118.9 15.2 3.2e-34 118.7 15.2 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F Abhydrolase_1 PF00561.20 ORX44946.1 - 2.9e-17 63.2 0.0 6.4e-13 48.9 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX44946.1 - 1.3e-13 50.8 0.1 1.5e-12 47.3 0.1 2.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX44946.1 - 7.5e-13 49.6 0.0 9.6e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX44946.1 - 3.7e-05 23.3 1.2 0.03 13.8 0.0 3.1 3 0 0 3 3 3 2 Prolyl oligopeptidase family DLH PF01738.18 ORX44946.1 - 0.0018 17.9 0.0 0.31 10.6 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family Esterase PF00756.20 ORX44946.1 - 0.0022 17.7 0.0 0.0067 16.1 0.0 1.7 2 0 0 2 2 2 1 Putative esterase HAD PF12710.7 ORX44946.1 - 0.012 16.0 0.0 0.02 15.3 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Thioesterase PF00975.20 ORX44946.1 - 0.013 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Peptidase_S15 PF02129.18 ORX44946.1 - 0.016 14.8 0.1 0.1 12.2 0.1 2.1 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_2 PF02230.16 ORX44946.1 - 0.019 14.8 0.1 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 ORX44946.1 - 0.024 14.3 0.0 0.069 12.8 0.0 1.9 2 1 0 2 2 2 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 ORX44946.1 - 0.053 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein zf-C2H2 PF00096.26 ORX44947.1 - 1e-13 50.9 6.2 2.2e-06 27.8 1.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX44947.1 - 2.5e-09 37.1 8.2 1.3e-05 25.4 0.2 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX44947.1 - 3.8e-09 36.6 6.1 0.0002 21.9 1.0 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 ORX44947.1 - 0.00017 21.8 0.3 0.00032 20.9 0.3 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ORX44947.1 - 0.00033 20.6 2.2 0.046 13.7 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX44947.1 - 0.00099 19.3 0.3 0.0085 16.4 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX44947.1 - 0.0029 17.9 0.9 0.039 14.3 0.2 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-RRN7 PF11781.8 ORX44947.1 - 0.033 13.9 1.9 6.3 6.6 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2HC_2 PF13913.6 ORX44947.1 - 0.087 12.7 3.0 0.83 9.6 0.4 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-BED PF02892.15 ORX44947.1 - 0.41 10.7 6.3 1.2 9.2 0.2 2.9 2 1 1 3 3 3 0 BED zinc finger zf-C2H2_11 PF16622.5 ORX44947.1 - 0.61 9.9 4.8 0.37 10.6 0.4 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type zf_C2H2_6 PF18450.1 ORX44947.1 - 7.2 6.4 5.7 1.2 8.9 1.7 1.8 2 0 0 2 2 2 0 Zinc Finger domain PDZ_1 PF12812.7 ORX44948.1 - 1.2e-32 111.7 0.1 6.8e-23 80.5 0.0 3.2 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 ORX44948.1 - 3e-21 76.9 0.1 6.4e-19 69.3 0.0 2.6 3 0 0 3 3 3 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 ORX44948.1 - 6.5e-18 64.8 0.0 2.9e-06 27.5 0.0 4.5 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 ORX44948.1 - 1.6e-14 53.4 0.1 2.4e-05 24.1 0.0 4.6 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 ORX44948.1 - 1.4e-09 38.1 0.1 0.003 17.9 0.0 4.0 4 0 0 4 4 4 3 PDZ domain Trypsin PF00089.26 ORX44948.1 - 0.0012 18.7 0.0 0.006 16.4 0.0 2.2 3 0 0 3 3 3 1 Trypsin PDZ_3 PF17815.1 ORX44948.1 - 0.01 15.7 0.0 0.28 11.0 0.0 2.8 3 1 0 3 3 3 0 PDZ domain Peptidase_S46 PF10459.9 ORX44948.1 - 0.07 11.8 0.3 0.19 10.3 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 Pga1 PF10333.9 ORX44949.1 - 0.0097 15.8 0.0 0.011 15.6 0.0 1.3 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tcf25 PF04910.14 ORX44950.1 - 8.7e-89 298.0 0.0 1.2e-88 297.5 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 TPR_2 PF07719.17 ORX44950.1 - 0.00033 20.6 0.2 0.044 13.9 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX44950.1 - 0.099 13.5 4.0 0.31 12.0 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX44950.1 - 0.12 12.3 0.2 0.33 10.8 0.2 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX44950.1 - 0.23 11.8 0.8 2.8 8.3 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat YL1 PF05764.13 ORX44950.1 - 1.4 9.0 11.0 3.3 7.8 11.0 1.6 1 0 0 1 1 1 0 YL1 nuclear protein DLH PF01738.18 ORX44952.1 - 1.3e-30 106.5 0.0 1.7e-30 106.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ORX44952.1 - 0.0025 18.5 0.0 0.0034 18.0 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ORX44952.1 - 0.0065 16.3 0.0 0.0098 15.7 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ORX44952.1 - 0.0077 15.9 0.0 0.0093 15.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 ORX44952.1 - 0.041 13.8 1.3 0.51 10.2 0.5 2.2 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF2048 PF09752.9 ORX44952.1 - 0.22 10.6 0.2 0.33 10.0 0.2 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Ribosomal_S3Ae PF01015.18 ORX44953.1 - 6e-74 248.0 4.7 7.1e-74 247.8 4.7 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family Med3 PF11593.8 ORX44953.1 - 0.005 16.1 0.1 0.0081 15.4 0.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Caudo_TAP PF02413.17 ORX44953.1 - 0.056 13.6 1.6 3.1 7.9 1.0 2.3 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK TipAS PF07739.13 ORX44953.1 - 0.08 13.5 0.2 0.84 10.2 0.0 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SUI1 PF01253.22 ORX44953.1 - 0.089 13.3 0.9 2 9.0 0.1 2.4 2 0 0 2 2 2 0 Translation initiation factor SUI1 CS PF04969.16 ORX44954.1 - 4.3e-08 34.1 0.2 6.1e-08 33.6 0.2 1.2 1 0 0 1 1 1 1 CS domain RasGEF PF00617.19 ORX44955.1 - 6.7e-43 146.9 0.1 1.5e-42 145.8 0.1 1.5 1 0 0 1 1 1 1 RasGEF domain NmrA PF05368.13 ORX44957.1 - 2.5e-08 33.8 0.0 2.1e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 ORX44957.1 - 1e-05 25.5 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Lact_bio_phlase PF09508.10 ORX44957.1 - 0.11 11.0 0.1 0.15 10.5 0.1 1.2 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain SGTA_dimer PF16546.5 ORX44958.1 - 3.8e-23 81.0 0.2 5.6e-23 80.5 0.2 1.3 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 ORX44959.1 - 9.5e-21 72.7 1.3 2.6e-11 42.8 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX44959.1 - 4.5e-17 60.7 0.8 4.1e-09 35.9 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX44959.1 - 6.4e-15 54.1 0.5 4.9e-07 29.5 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX44959.1 - 6e-13 48.3 3.2 1.9e-07 30.6 0.4 2.5 1 1 1 2 2 2 2 TPR repeat TPR_7 PF13176.6 ORX44959.1 - 1.5e-10 40.3 0.1 1.7e-05 24.5 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX44959.1 - 2.2e-10 40.2 0.8 0.012 16.0 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX44959.1 - 8.7e-09 35.5 0.3 0.00016 22.2 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX44959.1 - 1.3e-08 35.0 0.9 0.0039 17.5 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX44959.1 - 4e-07 29.7 1.0 0.014 15.2 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX44959.1 - 2.2e-06 28.1 0.8 2.2e-06 28.1 0.8 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX44959.1 - 4.7e-05 23.9 0.1 0.21 12.3 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX44959.1 - 0.00014 22.0 0.1 0.00021 21.5 0.1 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ORX44959.1 - 0.00051 19.3 0.2 0.31 10.2 0.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX44959.1 - 0.0022 18.5 0.6 3.8 8.4 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX44959.1 - 0.016 15.3 0.8 0.27 11.4 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat BTAD PF03704.17 ORX44959.1 - 0.033 14.6 0.1 0.066 13.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial transcriptional activator domain STI1 PF17830.1 ORX44959.1 - 0.084 12.8 13.1 5.5 7.0 9.9 2.7 2 0 0 2 2 2 0 STI1 domain Fis1_TPR_C PF14853.6 ORX44959.1 - 0.16 12.0 1.1 2.5 8.2 0.1 2.5 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 ORX44959.1 - 0.32 11.4 2.3 5.7 7.3 0.2 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat ACBP PF00887.19 ORX44960.1 - 3.6e-20 71.9 0.0 7.1e-20 71.0 0.0 1.4 1 0 0 1 1 1 1 Acyl CoA binding protein DUF4674 PF15719.5 ORX44960.1 - 0.1 12.6 0.0 0.1 12.6 0.0 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4674) CLZ PF16526.5 ORX44960.1 - 0.13 12.7 1.9 0.26 11.6 1.9 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels IFRD PF05004.13 ORX44960.1 - 0.17 10.9 2.4 0.45 9.6 2.4 1.6 2 0 0 2 2 2 0 Interferon-related developmental regulator (IFRD) Glyco_hydro_125 PF06824.11 ORX44961.1 - 4.7e-157 523.1 0.2 1.1e-156 522.0 0.0 1.6 2 0 0 2 2 2 1 Metal-independent alpha-mannosidase (GH125) Mnd1 PF03962.15 ORX44962.1 - 3.7e-23 81.6 0.6 7.2e-23 80.6 0.0 1.8 2 1 0 2 2 2 1 Mnd1 HTH domain LZ3wCH PF18517.1 ORX44962.1 - 1.3e-10 41.2 0.7 3.4e-10 39.9 0.7 1.7 1 0 0 1 1 1 1 Leucine zipper with capping helix domain WGG PF10273.9 ORX44962.1 - 0.026 15.2 0.2 1.1 10.0 0.1 2.3 2 0 0 2 2 2 0 Pre-rRNA-processing protein TSR2 ABC2_membrane PF01061.24 ORX44963.1 - 5.6e-77 257.9 68.8 3.3e-43 147.6 27.9 2.9 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 ORX44963.1 - 2.6e-34 118.7 0.0 6.1e-19 68.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ORX44963.1 - 4.7e-22 77.7 12.1 1.8e-17 63.0 0.0 3.7 4 0 0 4 4 4 2 CDR ABC transporter ABC_trans_N PF14510.6 ORX44963.1 - 1.1e-09 38.8 0.0 2.6e-09 37.6 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 ORX44963.1 - 9.6e-08 31.5 43.4 4.8e-06 25.9 20.0 2.7 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_16 PF13191.6 ORX44963.1 - 6.2e-05 23.4 0.0 0.012 16.0 0.0 2.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ORX44963.1 - 9.9e-05 22.3 0.1 0.44 10.3 0.0 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX44963.1 - 0.00014 21.8 1.8 0.0041 17.0 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ORX44963.1 - 0.00059 19.5 0.6 0.022 14.5 0.3 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain FEZ PF07763.13 ORX44963.1 - 0.014 15.1 0.2 0.03 14.1 0.2 1.4 1 0 0 1 1 1 0 FEZ-like protein AAA_25 PF13481.6 ORX44963.1 - 0.017 14.7 0.0 0.047 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX44963.1 - 0.028 14.6 0.1 0.51 10.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX44963.1 - 0.031 14.8 0.0 0.64 10.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ORX44963.1 - 0.036 14.3 0.0 1.2 9.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 ORX44963.1 - 0.056 13.2 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX44963.1 - 0.062 12.6 0.0 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 ORX44963.1 - 0.11 13.0 0.1 0.61 10.6 0.1 2.2 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ORX44963.1 - 0.15 11.6 0.2 0.95 9.0 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1 PF01926.23 ORX44963.1 - 0.24 11.5 1.6 12 6.0 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NUDIX PF00293.28 ORX44965.1 - 1.6e-13 50.8 0.0 2.3e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain FeThRed_B PF02943.15 ORX44967.1 - 0.55 10.3 3.6 2.8 8.0 2.9 2.1 2 1 0 2 2 2 0 Ferredoxin thioredoxin reductase catalytic beta chain SBDS PF01172.18 ORX45065.1 - 0.095 12.8 0.1 3.4 7.8 0.0 2.8 3 0 0 3 3 3 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF4218 PF13960.6 ORX45067.1 - 0.0014 18.3 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) GCP_N_terminal PF17681.1 ORX45069.1 - 7.2e-48 163.8 2.2 1.1e-47 163.2 0.1 2.0 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ORX45069.1 - 3.1e-28 99.1 11.7 1.3e-27 97.1 11.7 2.1 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal MAPEG PF01124.18 ORX45070.1 - 3.4e-24 85.2 0.1 4.2e-24 84.9 0.1 1.1 1 0 0 1 1 1 1 MAPEG family Hexokinase_1 PF00349.21 ORX45071.1 - 1.7e-07 31.4 0.0 0.02 14.8 0.0 2.1 1 1 1 2 2 2 2 Hexokinase Hexokinase_2 PF03727.16 ORX45071.1 - 4.9e-06 26.1 0.0 5.9e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase DUF4718 PF15842.5 ORX45072.1 - 0.05 13.4 0.7 0.057 13.2 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF3446 PF11928.8 ORX45072.1 - 1.2 9.4 15.6 0.19 12.1 9.0 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain UBX PF00789.20 ORX45073.1 - 2.9e-21 75.4 0.0 6.5e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 UBX domain Caldesmon PF02029.15 ORX45073.1 - 6.2e-06 25.2 10.3 7.7e-06 24.9 10.3 1.2 1 0 0 1 1 1 1 Caldesmon Thioredoxin_7 PF13899.6 ORX45073.1 - 0.025 14.7 0.2 0.075 13.2 0.2 1.8 1 0 0 1 1 1 0 Thioredoxin-like Asp-B-Hydro_N PF05279.11 ORX45073.1 - 0.35 10.9 16.0 0.49 10.4 16.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4407 PF14362.6 ORX45073.1 - 0.49 9.7 10.2 0.82 9.0 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vfa1 PF08432.10 ORX45073.1 - 2.5 8.4 20.5 4.8 7.5 20.5 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Myc-LZ PF02344.15 ORX45073.1 - 4.7 7.4 15.8 7.4 6.8 4.9 2.7 2 0 0 2 2 2 0 Myc leucine zipper domain Pkinase PF00069.25 ORX45074.1 - 3.8e-74 249.4 0.0 5.4e-74 248.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45074.1 - 1e-30 106.9 0.0 1.2e-21 77.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX45074.1 - 4.7e-08 32.7 1.6 0.048 13.0 0.0 3.1 2 1 1 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 ORX45074.1 - 0.0034 16.2 0.0 0.0055 15.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX45074.1 - 0.041 13.2 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX45074.1 - 0.097 11.6 0.4 0.23 10.3 0.4 1.6 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX45074.1 - 0.1 12.5 0.0 0.38 10.6 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family SGT1 PF07093.11 ORX45075.1 - 1.7e-92 310.8 13.2 1.1e-80 271.7 0.0 2.4 2 1 0 2 2 2 2 SGT1 protein ORC6 PF05460.13 ORX45075.1 - 0.036 13.3 0.0 0.055 12.7 0.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) ECH_2 PF16113.5 ORX45076.1 - 2.5e-128 428.3 0.6 4.1e-128 427.6 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX45076.1 - 7.2e-32 110.7 0.1 7.4e-30 104.1 0.0 2.3 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase FliG_N PF14842.6 ORX45076.1 - 0.019 15.5 0.0 0.062 13.9 0.0 1.9 1 0 0 1 1 1 0 FliG N-terminal domain N2227 PF07942.12 ORX45078.1 - 6.7e-103 343.6 0.0 9.5e-103 343.1 0.0 1.2 1 0 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 ORX45078.1 - 0.0037 17.1 0.1 0.014 15.2 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX45078.1 - 0.009 16.7 0.0 0.039 14.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX45078.1 - 0.059 14.0 0.0 0.72 10.5 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 ORX45078.1 - 0.18 12.5 0.0 2.8 8.7 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase domain ECH_2 PF16113.5 ORX45079.1 - 8.8e-08 32.0 0.0 1.3e-06 28.2 0.0 2.3 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX45079.1 - 0.0033 16.8 0.0 3.4 6.9 0.0 3.1 2 1 1 3 3 3 2 Enoyl-CoA hydratase/isomerase UPF0047 PF01894.17 ORX45079.1 - 0.14 12.3 0.1 0.31 11.2 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 PEMT PF04191.13 ORX45080.1 - 1.9e-54 182.5 12.1 5.1e-33 113.7 1.4 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase Cas1_AcylT PF07779.12 ORX45081.1 - 1e-129 433.5 21.7 1.7e-129 432.9 21.7 1.2 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p PC-Esterase PF13839.6 ORX45081.1 - 9.2e-05 22.3 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p zf-C2H2 PF00096.26 ORX45082.1 - 1.9e-12 46.9 20.6 1.1e-06 28.7 1.2 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX45082.1 - 1.1e-10 41.4 11.0 0.00023 21.4 0.5 3.8 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX45082.1 - 3.8e-10 39.7 17.6 0.00023 21.7 0.4 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX45082.1 - 1.5e-07 31.5 2.4 0.00069 19.8 0.0 3.3 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX45082.1 - 1.4e-06 28.1 6.2 0.0001 22.2 0.1 3.3 3 0 0 3 3 3 1 C2H2-type zinc finger zf_ZIC PF18366.1 ORX45082.1 - 6.5e-05 23.0 1.3 0.43 10.7 0.0 2.7 3 0 0 3 3 2 2 Zic proteins zinc finger domain zf-met PF12874.7 ORX45082.1 - 0.00016 21.9 3.4 0.19 12.2 0.0 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 ORX45082.1 - 0.0021 18.7 5.0 5.6 7.7 0.1 3.3 2 1 1 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-Di19 PF05605.12 ORX45082.1 - 0.006 16.9 4.6 0.006 16.9 4.6 2.4 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding Rad50_zn_hook PF04423.14 ORX45082.1 - 0.019 14.8 0.1 0.043 13.7 0.1 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif Actin_micro PF17003.5 ORX45082.1 - 0.092 11.9 4.4 0.82 8.8 0.9 2.7 1 1 0 2 2 2 0 Putative actin-like family zf-C2H2_2 PF12756.7 ORX45082.1 - 0.39 11.1 7.6 1.5 9.2 0.0 3.1 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_9 PF14369.6 ORX45082.1 - 0.41 11.0 3.2 24 5.3 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon zf-C2H2_9 PF16293.5 ORX45082.1 - 0.69 9.8 2.6 2.8 7.9 0.0 2.7 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) DUF629 PF04780.12 ORX45082.1 - 0.91 8.0 6.4 1.2 7.5 0.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF629) zinc-ribbons_6 PF07191.12 ORX45082.1 - 1.2 9.2 4.4 9 6.4 3.4 2.5 1 1 1 2 2 2 0 zinc-ribbons Mito_carr PF00153.27 ORX45084.1 - 2.9e-56 187.4 6.6 4.1e-19 68.3 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein P5CR_dimer PF14748.6 ORX45084.1 - 0.026 14.8 1.8 0.15 12.3 0.1 2.7 3 0 0 3 3 3 0 Pyrroline-5-carboxylate reductase dimerisation PrcB_C PF14343.6 ORX45084.1 - 0.028 14.5 0.0 2.4 8.4 0.0 2.3 2 0 0 2 2 2 0 PrcB C-terminal Wzz PF02706.15 ORX45084.1 - 0.1 12.9 0.0 0.41 11.0 0.0 2.0 1 0 0 1 1 1 0 Chain length determinant protein peroxidase PF00141.23 ORX45085.1 - 8.2e-46 156.5 0.0 1.1e-45 156.1 0.0 1.2 1 0 0 1 1 1 1 Peroxidase tRNA-synt_His PF13393.6 ORX45086.1 - 3.4e-39 134.9 0.3 4.4e-34 118.2 0.0 2.5 2 1 1 3 3 3 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ORX45086.1 - 5.5e-15 55.3 0.3 1.2e-14 54.3 0.3 1.6 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 ORX45086.1 - 1.5e-07 31.3 0.2 2.8e-07 30.3 0.2 1.4 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs WHEP-TRS PF00458.20 ORX45086.1 - 6.7e-05 23.0 6.5 6.7e-05 23.0 6.5 2.5 3 0 0 3 3 3 1 WHEP-TRS domain DUF1820 PF08850.11 ORX45086.1 - 0.00061 20.2 0.3 0.0058 17.1 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1820) tRNA-synt_2 PF00152.20 ORX45086.1 - 0.0028 16.8 0.8 0.026 13.6 0.4 2.5 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) RasGEF PF00617.19 ORX45087.1 - 1.1e-05 25.7 0.1 3.3e-05 24.2 0.1 1.8 1 1 0 1 1 1 1 RasGEF domain Pet191_N PF10203.9 ORX45087.1 - 0.025 14.9 6.6 0.085 13.2 6.6 1.9 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 tRNA-synt_1g PF09334.11 ORX45088.1 - 6.8e-102 341.1 0.4 8e-101 337.6 0.4 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX45088.1 - 1.8e-21 76.1 4.9 1.4e-09 36.8 1.2 3.8 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ORX45088.1 - 1.6e-14 54.0 0.1 1.8e-07 30.8 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 ORX45088.1 - 7.9e-05 22.7 0.0 0.00015 21.7 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA EBP PF05241.12 ORX45089.1 - 6.2e-45 152.8 12.5 7.8e-45 152.5 12.5 1.0 1 0 0 1 1 1 1 Emopamil binding protein GT87 PF09594.10 ORX45089.1 - 0.00083 19.1 1.4 0.0012 18.7 1.4 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 87 A1_Propeptide PF07966.12 ORX45089.1 - 0.21 11.5 0.0 0.36 10.7 0.0 1.4 1 0 0 1 1 1 0 A1 Propeptide Arrestin_C PF02752.22 ORX45090.1 - 0.09 13.2 0.1 0.38 11.2 0.0 2.0 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain ADH_zinc_N PF00107.26 ORX45091.1 - 5.7e-21 74.9 0.0 9.4e-21 74.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX45091.1 - 5e-10 39.3 0.0 1.8e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX45091.1 - 8.8e-09 36.5 0.0 1.5e-08 35.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NmrA PF05368.13 ORX45092.1 - 0.00086 18.9 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family Filament PF00038.21 ORX45094.1 - 1.2 8.7 77.9 0.012 15.2 49.6 3.9 1 1 2 3 3 3 0 Intermediate filament protein RPE65 PF03055.15 ORX45095.1 - 5.4e-81 273.1 0.4 6.6e-81 272.8 0.4 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein HIG_1_N PF04588.13 ORX45096.1 - 3.6e-07 30.3 2.8 3.6e-07 30.3 2.8 1.9 2 0 0 2 2 2 1 Hypoxia induced protein conserved region 7TMR-DISM_7TM PF07695.11 ORX45096.1 - 0.066 13.1 1.3 0.079 12.8 0.1 1.6 2 0 0 2 2 2 0 7TM diverse intracellular signalling ANAPC4_WD40 PF12894.7 ORX45097.1 - 0.12 12.7 0.1 2.5 8.5 0.1 2.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Aminotran_3 PF00202.21 ORX45098.1 - 7.3e-119 397.0 0.0 8.8e-119 396.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ORX45098.1 - 0.00014 21.2 0.0 0.0013 17.9 0.0 2.1 2 0 0 2 2 2 1 Aminotransferase class I and II Phosphoesterase PF04185.14 ORX45100.1 - 1.2e-87 294.4 0.5 1.7e-87 293.9 0.5 1.2 1 0 0 1 1 1 1 Phosphoesterase family Amino_oxidase PF01593.24 ORX45101.1 - 2.9e-28 99.3 0.0 3.5e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX45101.1 - 3.7e-11 43.1 0.0 7.9e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX45101.1 - 2.3e-06 27.4 0.0 1.9e-05 24.4 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX45101.1 - 5.6e-05 22.5 0.0 0.012 14.9 0.0 2.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX45101.1 - 9.7e-05 21.7 0.0 0.00019 20.7 0.0 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_9 PF13454.6 ORX45101.1 - 0.0013 18.8 0.0 0.092 12.7 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding MCRA PF06100.11 ORX45101.1 - 0.0017 17.2 0.0 0.0032 16.3 0.0 1.3 1 0 0 1 1 1 1 MCRA family Pyr_redox PF00070.27 ORX45101.1 - 0.0037 17.8 0.0 0.074 13.6 0.1 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ORX45101.1 - 0.004 16.0 0.0 0.0063 15.4 0.0 1.2 1 0 0 1 1 1 1 Tryptophan halogenase GIDA PF01134.22 ORX45101.1 - 0.022 13.9 0.1 1.5 7.8 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 ORX45101.1 - 0.041 12.6 0.1 0.98 8.0 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein Mqo PF06039.15 ORX45101.1 - 0.11 11.1 0.0 2.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) LIM PF00412.22 ORX45102.1 - 1.9e-37 127.3 60.4 1.3e-11 44.5 9.0 4.1 4 0 0 4 4 4 4 LIM domain TGase_elicitor PF16683.5 ORX45102.1 - 0.081 11.7 3.6 0.12 11.1 3.6 1.2 1 0 0 1 1 1 0 Transglutaminase elicitor Baculo_PEP_C PF04513.12 ORX45103.1 - 0.0016 18.5 41.1 0.04 14.0 12.0 3.3 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Dad2 PF08654.10 ORX45103.1 - 0.011 16.2 5.0 6.8 7.2 0.3 3.8 3 1 1 4 4 4 0 DASH complex subunit Dad2 DLP_helical PF18709.1 ORX45103.1 - 0.014 14.7 0.1 0.026 13.7 0.1 1.4 1 1 0 1 1 1 0 Dynamin-like helical domain zf-C3HC4_2 PF13923.6 ORX45104.1 - 0.036 13.9 1.5 0.098 12.5 1.5 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX45104.1 - 0.34 11.0 4.6 0.16 12.1 2.1 1.9 2 1 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 ORX45104.1 - 2 8.8 6.2 0.57 10.6 2.6 2.1 2 1 0 2 2 2 0 Ring finger domain Pkinase PF00069.25 ORX45105.1 - 5.7e-57 193.1 0.0 7.4e-57 192.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45105.1 - 2.1e-24 86.2 0.0 1.5e-23 83.4 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX45105.1 - 0.0011 18.9 0.0 0.0028 17.6 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX45105.1 - 0.029 14.0 0.0 0.083 12.5 0.0 1.7 1 1 1 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 ORX45105.1 - 0.036 13.7 0.1 0.085 12.5 0.0 1.6 1 1 0 1 1 1 0 RIO1 family PGM1_C PF18105.1 ORX45107.1 - 0.046 13.3 1.1 5.6 6.6 0.1 2.4 2 0 0 2 2 2 0 PGM1 C-terminal domain Bestrophin PF01062.21 ORX45108.1 - 1.8e-45 155.6 0.0 7.6e-22 78.0 0.0 2.0 1 1 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel Xan_ur_permease PF00860.20 ORX45109.1 - 4.2e-25 88.3 32.8 2.8e-24 85.6 28.7 2.8 2 1 0 2 2 2 1 Permease family Pox_A32 PF04665.12 ORX45109.1 - 0.082 12.4 0.4 0.13 11.7 0.4 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein Kazal_2 PF07648.15 ORX45109.1 - 0.11 12.7 2.5 0.21 11.7 2.5 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain AP-5_subunit_s1 PF15001.6 ORX45110.1 - 0.072 13.1 0.4 0.12 12.4 0.4 1.2 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 tRNA-synt_1 PF00133.22 ORX45111.1 - 3.3e-181 603.6 0.0 3.6e-180 600.2 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX45111.1 - 5.2e-33 114.2 0.0 9.8e-33 113.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX45111.1 - 3.4e-18 65.6 0.7 5.5e-07 28.7 0.1 4.8 3 2 1 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ORX45111.1 - 3.2e-08 33.3 0.0 1.9e-07 30.8 0.0 2.1 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 ORX45111.1 - 5.4e-05 23.4 5.1 0.00012 22.3 5.1 1.6 1 0 0 1 1 1 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1b PF00579.25 ORX45111.1 - 0.028 13.7 0.0 0.57 9.4 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (W and Y) tRNA-synt_1e PF01406.19 ORX45111.1 - 0.031 13.6 0.0 0.51 9.6 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain ABC_membrane PF00664.23 ORX45112.1 - 1.8e-119 398.4 28.9 1.1e-62 212.2 10.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX45112.1 - 1.6e-68 229.5 0.1 5.6e-33 114.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX45112.1 - 2.7e-15 56.4 4.1 8e-06 25.4 0.0 4.3 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX45112.1 - 1.2e-09 38.8 0.2 0.014 15.8 0.0 3.9 3 0 0 3 3 3 2 AAA ATPase domain ABC_ATPase PF09818.9 ORX45112.1 - 1.4e-09 37.3 0.5 0.00093 18.1 0.1 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 ORX45112.1 - 4.8e-09 36.6 0.3 0.0004 20.7 0.0 3.6 2 2 0 2 2 2 2 AAA domain AAA_30 PF13604.6 ORX45112.1 - 3e-07 30.4 0.3 0.059 13.1 0.0 3.7 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX45112.1 - 4.9e-07 29.4 0.1 0.052 13.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX45112.1 - 2.1e-06 27.7 0.0 0.067 13.1 0.0 3.0 3 0 0 3 3 2 2 RsgA GTPase AAA_7 PF12775.7 ORX45112.1 - 5e-05 22.9 0.0 0.21 11.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region G-alpha PF00503.20 ORX45112.1 - 0.00013 21.2 0.0 0.15 11.2 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Rad17 PF03215.15 ORX45112.1 - 0.00019 21.4 0.0 0.066 13.1 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain Zeta_toxin PF06414.12 ORX45112.1 - 0.00037 19.8 0.0 0.3 10.3 0.0 3.3 3 0 0 3 3 3 1 Zeta toxin AAA_28 PF13521.6 ORX45112.1 - 0.00045 20.5 0.1 2.4 8.4 0.1 3.3 2 1 1 3 3 3 2 AAA domain AAA PF00004.29 ORX45112.1 - 0.00079 19.9 10.0 0.74 10.2 3.5 4.5 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SRP54 PF00448.22 ORX45112.1 - 0.00095 18.8 0.0 1.3 8.6 0.0 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ORX45112.1 - 0.00097 19.3 0.0 2.4 8.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 ORX45112.1 - 0.0011 19.2 3.7 0.67 10.2 0.4 3.8 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 ORX45112.1 - 0.0036 17.8 0.1 11 6.6 0.0 3.5 3 0 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ORX45112.1 - 0.0043 16.6 0.1 6.6 6.3 0.0 3.6 3 0 0 3 3 3 0 AAA domain AAA_24 PF13479.6 ORX45112.1 - 0.0063 16.3 0.0 2.5 7.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX45112.1 - 0.0088 16.0 0.1 5.8 6.9 0.0 3.8 4 0 0 4 4 4 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ORX45112.1 - 0.012 15.9 0.4 4.5 7.7 0.1 3.3 3 1 0 3 3 2 0 RNA helicase AAA_21 PF13304.6 ORX45112.1 - 0.013 15.3 0.0 47 3.7 0.0 4.1 4 0 0 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ORX45112.1 - 0.013 15.2 0.9 3.9 7.1 0.0 2.8 3 0 0 3 3 2 0 AAA ATPase domain IstB_IS21 PF01695.17 ORX45112.1 - 0.017 14.9 1.6 4.9 6.8 0.0 4.0 4 0 0 4 4 4 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 ORX45112.1 - 0.051 13.7 0.8 16 5.6 0.0 3.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase Cytidylate_kin PF02224.18 ORX45112.1 - 0.055 13.2 0.1 15 5.2 0.0 2.9 3 0 0 3 3 3 0 Cytidylate kinase APS_kinase PF01583.20 ORX45112.1 - 0.08 12.8 0.0 1.8 8.4 0.0 2.6 2 0 0 2 2 2 0 Adenylylsulphate kinase DUF87 PF01935.17 ORX45112.1 - 0.099 12.7 0.8 28 4.7 0.0 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain AAA_23 PF13476.6 ORX45112.1 - 1.2 9.6 13.8 4.7 7.7 0.2 4.0 4 0 0 4 4 3 0 AAA domain NESP55 PF06390.12 ORX45112.1 - 7 6.2 6.3 4.7 6.7 2.6 2.1 2 0 0 2 2 2 0 Neuroendocrine-specific golgi protein P55 (NESP55) tRNA-synt_2 PF00152.20 ORX45113.1 - 3.6e-74 249.7 0.0 4.6e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX45113.1 - 7.5e-10 38.7 0.1 1.7e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX45113.1 - 1e-07 31.7 0.0 0.00099 18.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 ORX45113.1 - 0.087 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain Transglycosylas PF06737.14 ORX45114.1 - 0.16 12.7 0.1 0.38 11.4 0.1 1.6 1 0 0 1 1 1 0 Transglycosylase-like domain DDRGK PF09756.9 ORX45115.1 - 1.9e-08 34.1 22.1 2.7e-08 33.6 22.1 1.2 1 0 0 1 1 1 1 DDRGK domain DUF3573 PF12097.8 ORX45115.1 - 0.77 8.5 5.5 1.6 7.4 5.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Cnn_1N PF07989.11 ORX45116.1 - 5.5e-24 84.1 3.6 5.5e-24 84.1 3.6 8.8 4 2 3 8 8 8 1 Centrosomin N-terminal motif 1 YjgF_endoribonc PF14588.6 ORX45116.1 - 0.077 13.1 0.5 14 5.8 0.1 2.4 2 0 0 2 2 2 0 YjgF/chorismate_mutase-like, putative endoribonuclease Pkinase PF00069.25 ORX45117.1 - 5.6e-38 130.8 0.0 5.6e-37 127.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45117.1 - 1.8e-10 40.5 0.2 5.7e-05 22.5 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase FTA2 PF13095.6 ORX45117.1 - 0.083 12.5 0.1 2.6 7.6 0.0 2.4 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ORX45117.1 - 0.26 10.0 2.1 0.38 9.5 0.2 2.0 2 1 0 2 2 2 0 Fungal protein kinase Tetraspanin PF00335.20 ORX45118.1 - 7.3e-13 48.8 11.6 1.4e-12 47.8 11.6 1.5 1 1 0 1 1 1 1 Tetraspanin family Babuvirus_MP PF07234.11 ORX45118.1 - 0.02 15.0 2.9 0.079 13.1 0.1 2.3 2 0 0 2 2 2 0 Movement and RNA silencing protein Ctr PF04145.15 ORX45118.1 - 2.9 8.5 5.3 2.5 8.7 0.1 2.6 2 1 0 2 2 2 0 Ctr copper transporter family DUF3784 PF12650.7 ORX45118.1 - 5.2 7.3 12.5 1.1 9.5 1.3 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF3784) SUR7 PF06687.12 ORX45118.1 - 9.7 5.8 11.4 2 8.0 4.0 2.5 2 1 0 2 2 2 0 SUR7/PalI family Adaptin_N PF01602.20 ORX45119.1 - 6.8e-142 473.7 10.3 8.6e-142 473.3 10.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX45119.1 - 7.5e-65 217.9 6.6 9.5e-64 214.3 1.8 3.1 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX45119.1 - 5e-16 58.9 6.5 3.1e-06 27.5 0.0 5.3 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.22 ORX45119.1 - 1.8e-11 43.2 2.9 0.0086 16.3 0.0 5.8 7 0 0 7 7 5 2 HEAT repeat Arm PF00514.23 ORX45119.1 - 4.1e-08 33.0 1.9 0.014 15.5 0.0 4.6 4 0 0 4 4 4 2 Armadillo/beta-catenin-like repeat Cnd3 PF12719.7 ORX45119.1 - 7.3e-05 22.1 0.2 0.013 14.7 0.0 2.6 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ORX45119.1 - 0.00012 21.8 1.2 0.26 10.8 0.0 4.2 3 1 1 4 4 4 1 CLASP N terminal HEAT_EZ PF13513.6 ORX45119.1 - 0.00042 20.7 1.6 0.46 11.1 0.1 4.7 4 1 1 5 5 5 1 HEAT-like repeat RIX1 PF08167.12 ORX45119.1 - 0.00064 19.5 1.8 0.96 9.2 0.0 3.8 4 0 0 4 4 4 2 rRNA processing/ribosome biogenesis Arm_2 PF04826.13 ORX45119.1 - 0.00099 18.6 0.5 0.002 17.7 0.5 1.5 1 0 0 1 1 1 1 Armadillo-like RasGEF_N_2 PF14663.6 ORX45119.1 - 0.0035 17.7 0.7 0.11 12.9 0.1 3.6 3 2 2 5 5 5 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RTP1_C1 PF10363.9 ORX45119.1 - 0.0039 17.3 3.5 2.9 8.1 0.1 4.1 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ORX45119.1 - 0.5 11.0 5.0 0.29 11.8 0.2 2.9 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region ParcG PF10274.9 ORX45119.1 - 0.61 10.2 6.9 0.69 10.0 0.1 3.5 3 1 0 4 4 4 0 Parkin co-regulated protein AAA_22 PF13401.6 ORX45120.1 - 8.2e-15 55.3 0.0 2.5e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX45120.1 - 4.3e-14 53.1 0.2 1.4e-12 48.2 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX45120.1 - 4.7e-12 46.6 0.6 2e-09 38.1 0.1 3.2 2 1 0 2 2 2 1 AAA ATPase domain NACHT PF05729.12 ORX45120.1 - 6.1e-08 32.8 0.0 1.3e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain TniB PF05621.11 ORX45120.1 - 6.6e-08 32.2 0.1 1.8e-07 30.8 0.0 1.8 1 1 1 2 2 2 1 Bacterial TniB protein AAA_lid_10 PF17872.1 ORX45120.1 - 6.3e-07 29.4 0.1 2.1e-06 27.8 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain Cdc6_C PF09079.11 ORX45120.1 - 0.00042 20.2 0.0 0.001 19.0 0.0 1.6 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain DUF2075 PF09848.9 ORX45120.1 - 0.00072 18.9 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ORX45120.1 - 0.00076 19.8 1.8 0.0042 17.4 0.4 2.6 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX45120.1 - 0.0034 17.1 0.0 0.013 15.2 0.0 1.9 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ORX45120.1 - 0.0072 16.3 2.9 0.048 13.6 0.6 2.8 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea TPR_MalT PF17874.1 ORX45120.1 - 0.0088 15.5 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 MalT-like TPR region AAA_5 PF07728.14 ORX45120.1 - 0.011 15.7 0.7 0.58 10.1 0.2 3.2 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX45120.1 - 0.02 14.6 0.0 0.047 13.4 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 ORX45120.1 - 0.022 14.0 0.0 0.052 12.8 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 ORX45120.1 - 0.031 14.0 0.1 0.098 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ORX45120.1 - 0.05 12.8 0.1 0.12 11.6 0.1 1.6 1 0 0 1 1 1 0 NB-ARC domain AAA_28 PF13521.6 ORX45120.1 - 0.051 13.8 0.1 0.41 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX45120.1 - 0.062 13.7 0.1 0.3 11.5 0.0 2.3 2 1 0 2 2 2 0 RNA helicase AAA_25 PF13481.6 ORX45120.1 - 0.077 12.6 0.1 0.35 10.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain DUF2656 PF10847.8 ORX45120.1 - 0.11 12.6 1.2 0.39 10.8 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2656) ResIII PF04851.15 ORX45120.1 - 0.12 12.3 3.6 0.28 11.2 0.1 3.1 3 2 2 5 5 5 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 ORX45120.1 - 0.21 10.7 3.2 4.3 6.4 0.0 2.5 2 1 1 3 3 3 0 TIP49 P-loop domain PK PF00224.21 ORX45121.1 - 2.3e-154 513.4 0.5 2.8e-154 513.2 0.5 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ORX45121.1 - 1e-39 135.4 0.0 2.3e-39 134.2 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ORX45121.1 - 0.00075 18.7 0.1 0.0023 17.1 0.0 1.7 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Phosphoesterase PF04185.14 ORX45122.1 - 4.1e-72 243.3 2.4 4.8e-72 243.1 2.4 1.0 1 0 0 1 1 1 1 Phosphoesterase family WAC_Acf1_DNA_bd PF10537.9 ORX45123.1 - 4.4e-27 94.5 1.0 1.6e-26 92.8 1.0 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 ORX45123.1 - 2.8e-21 75.8 2.6 4.3e-21 75.2 0.2 2.7 2 0 0 2 2 2 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 ORX45123.1 - 1.9e-05 24.9 0.0 5.4e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 DDT domain WHIM1 PF15612.6 ORX45123.1 - 0.00062 19.3 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PHF5 PF03660.14 ORX45124.1 - 1.6e-51 172.8 9.4 1.8e-51 172.7 9.4 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 ORX45124.1 - 0.13 10.1 6.9 0.14 10.0 6.9 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 ORX45124.1 - 7.2 7.0 16.3 1.3 9.4 1.5 2.8 1 1 1 2 2 2 0 C1 domain Aa_trans PF01490.18 ORX45125.1 - 7.7e-61 206.0 27.9 8.9e-61 205.8 27.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX45125.1 - 0.0006 19.0 13.9 0.0006 19.0 13.9 2.1 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family TMEM237 PF15383.6 ORX45125.1 - 0.1 11.6 1.8 0.73 8.9 0.2 2.3 2 0 0 2 2 2 0 Transmembrane protein 237 Kelch_2 PF07646.15 ORX45126.1 - 4.2e-15 55.0 0.2 0.00053 19.9 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 ORX45126.1 - 6.1e-15 54.8 0.5 0.00077 19.4 0.0 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 ORX45126.1 - 1.3e-12 47.7 2.6 1.6e-05 25.0 0.0 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_4 PF13418.6 ORX45126.1 - 1.5e-12 47.3 0.2 0.053 13.5 0.0 4.5 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX45126.1 - 2.3e-11 43.6 1.5 0.0056 16.9 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ORX45126.1 - 2.9e-09 36.3 0.8 0.09 12.4 0.0 4.1 4 0 0 4 4 4 3 Kelch motif BTB PF00651.31 ORX45126.1 - 5.6e-08 33.0 0.0 1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain RRF PF01765.19 ORX45127.1 - 5.4e-46 156.5 6.3 7.6e-46 156.0 6.3 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Baculo_PEP_C PF04513.12 ORX45127.1 - 0.02 14.9 2.2 0.28 11.2 1.2 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus NAAA-beta PF15508.6 ORX45127.1 - 0.14 12.5 0.4 26 5.2 0.0 3.1 4 0 0 4 4 4 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase S-AdoMet_synt_M PF02772.16 ORX45127.1 - 0.18 12.1 1.0 0.32 11.3 0.5 1.7 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, central domain YtxH PF12732.7 ORX45127.1 - 4 8.0 6.7 2.4 8.8 3.4 2.3 2 0 0 2 2 2 0 YtxH-like protein TMPIT PF07851.13 ORX45127.1 - 4.1 6.5 4.8 5.3 6.2 4.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein HSCB_C PF07743.13 ORX45127.1 - 4.3 7.9 6.6 4 8.0 3.5 2.4 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain Acyl-CoA_dh_1 PF00441.24 ORX45128.1 - 1.6e-42 145.3 0.0 6.1e-42 143.4 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX45128.1 - 4e-38 130.6 0.0 7e-38 129.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ORX45128.1 - 5.2e-26 90.7 0.0 1.2e-25 89.5 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX45128.1 - 5.8e-16 59.0 0.0 1e-13 51.7 0.0 2.2 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_ox_N PF14749.6 ORX45128.1 - 0.2 12.2 0.0 0.44 11.1 0.0 1.7 1 1 0 1 1 1 0 Acyl-coenzyme A oxidase N-terminal UCH PF00443.29 ORX45129.1 - 3.6e-69 233.1 0.5 6.7e-69 232.2 0.5 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX45129.1 - 7.4e-23 81.6 1.8 1e-21 77.9 1.8 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP8_dimer PF08969.11 ORX45129.1 - 4.9e-06 26.7 0.1 9.4e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 USP8 dimerisation domain Rhodanese PF00581.20 ORX45129.1 - 0.00015 22.3 0.0 0.00034 21.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 ORX45129.1 - 0.046 13.5 0.2 0.12 12.1 0.2 1.7 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Cytomega_UL20A PF05984.12 ORX45129.1 - 0.13 12.6 0.8 0.39 11.0 0.8 1.8 1 0 0 1 1 1 0 Cytomegalovirus UL20A protein zf-CCHC PF00098.23 ORX45130.1 - 0.00051 20.0 5.3 0.0013 18.7 5.3 1.7 1 0 0 1 1 1 1 Zinc knuckle PhaP_Bmeg PF09602.10 ORX45130.1 - 0.017 15.1 0.0 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Crystall PF00030.19 ORX45130.1 - 0.14 12.4 0.1 0.69 10.2 0.1 2.0 2 0 0 2 2 2 0 Beta/Gamma crystallin ShK PF01549.24 ORX45130.1 - 0.42 11.2 7.2 5.5 7.6 5.7 2.5 2 0 0 2 2 2 0 ShK domain-like zf-CCHC PF00098.23 ORX45131.1 - 8.9e-07 28.7 11.5 0.0027 17.7 0.5 2.7 2 1 0 2 2 2 2 Zinc knuckle zf-CCHC_2 PF13696.6 ORX45131.1 - 0.005 16.6 8.6 0.075 12.9 0.2 2.2 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 ORX45131.1 - 0.13 12.0 4.8 1.1 9.1 0.7 2.2 2 0 0 2 2 2 0 Zinc knuckle 4HBT_3 PF13622.6 ORX45250.1 - 6.8e-25 88.8 0.0 8.2e-25 88.5 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Presenilin PF01080.17 ORX45251.1 - 4.2e-71 239.8 0.1 7.8e-71 238.9 0.1 1.4 1 1 0 1 1 1 1 Presenilin SPP PF06550.11 ORX45251.1 - 0.0003 20.4 0.3 0.0019 17.7 0.1 2.0 2 0 0 2 2 2 1 Signal-peptide peptidase, presenilin aspartyl protease Peptidase_A22B PF04258.13 ORX45251.1 - 0.32 10.5 7.8 0.92 9.0 5.9 2.6 2 1 0 2 2 2 0 Signal peptide peptidase Zn_clus PF00172.18 ORX45252.1 - 1.2e-08 34.9 16.0 1.8e-08 34.3 16.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Q_salvage PF10343.9 ORX45253.1 - 1.9e-25 90.0 0.0 6.7e-24 85.0 0.0 2.4 3 0 0 3 3 3 2 Potential Queuosine, Q, salvage protein family CBFD_NFYB_HMF PF00808.23 ORX45254.1 - 1.7e-17 63.5 0.1 3.3e-17 62.5 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX45254.1 - 7.2e-07 29.6 2.6 3.3e-06 27.5 0.1 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX45254.1 - 0.00079 19.5 0.0 0.0013 18.8 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-W PF15510.6 ORX45254.1 - 0.082 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 CENP-W protein BUD22 PF09073.10 ORX45254.1 - 0.26 10.6 13.4 0.25 10.7 13.4 1.1 1 0 0 1 1 1 0 BUD22 NPR3 PF03666.13 ORX45254.1 - 4.5 6.0 9.4 5.7 5.6 9.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NIPSNAP PF07978.13 ORX45255.1 - 4.3e-38 129.6 0.1 2.2e-24 85.6 0.1 2.2 2 0 0 2 2 2 2 NIPSNAP DUF1687 PF07955.11 ORX45256.1 - 6.3e-13 49.3 0.2 3e-12 47.1 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) Pkinase PF00069.25 ORX45257.1 - 8.2e-50 169.6 0.0 1.3e-49 169.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45257.1 - 6e-21 74.9 0.0 8.4e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX45257.1 - 8e-05 22.7 0.0 0.00021 21.3 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX45257.1 - 0.07 12.4 0.0 0.25 10.6 0.0 1.8 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 ORX45257.1 - 0.085 11.6 0.1 0.17 10.6 0.1 1.6 1 1 0 1 1 1 0 Fungal protein kinase FTA2 PF13095.6 ORX45257.1 - 0.1 12.2 0.0 6.3 6.4 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 ORX45257.1 - 0.11 12.1 1.7 0.99 9.0 0.0 2.3 2 0 0 2 2 2 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ORX45257.1 - 0.22 10.4 0.0 0.22 10.4 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain ketoacyl-synt PF00109.26 ORX45258.1 - 3.4e-61 207.0 4.2 1.1e-60 205.3 1.3 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ORX45258.1 - 1.3e-37 128.4 1.3 2.4e-37 127.6 1.3 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ORX45258.1 - 1.6e-06 27.7 0.3 7.2e-06 25.6 0.1 1.9 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX45258.1 - 0.037 13.7 5.6 1.6 8.4 0.2 3.7 3 1 1 4 4 4 0 Thiolase, C-terminal domain KAsynt_C_assoc PF16197.5 ORX45258.1 - 0.072 13.5 0.0 1.1 9.8 0.0 2.3 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension PSI_PSAK PF01241.18 ORX45258.1 - 0.33 11.0 3.2 3.1 7.9 0.0 3.3 2 2 1 3 3 3 0 Photosystem I psaG / psaK Rpr2 PF04032.16 ORX45259.1 - 1.3e-18 67.1 0.5 1.8e-18 66.6 0.5 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DZR PF12773.7 ORX45259.1 - 0.077 13.0 0.7 0.17 11.9 0.7 1.6 1 0 0 1 1 1 0 Double zinc ribbon Aldedh PF00171.22 ORX45260.1 - 1e-22 80.3 0.0 1.2e-22 80.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rpr2 PF04032.16 ORX45261.1 - 3.3e-13 49.7 0.1 4.8e-13 49.2 0.1 1.3 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain Ribosomal_L40e PF01020.17 ORX45261.1 - 0.025 14.5 0.5 0.58 10.1 0.1 2.2 1 1 1 2 2 2 0 Ribosomal L40e family Aldedh PF00171.22 ORX45262.1 - 1.3e-79 267.9 0.0 1.6e-79 267.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ORX45262.1 - 0.0002 20.5 0.0 0.0003 20.0 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) ASL_C PF08328.11 ORX45262.1 - 0.045 13.9 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal ArAE_1_C PF11728.8 ORX45262.1 - 0.12 12.3 0.8 0.36 10.8 0.4 1.8 2 0 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain Med8 PF10232.9 ORX45263.1 - 1.1e-06 28.5 0.0 2.1e-06 27.5 0.0 1.4 1 1 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Rad60-SLD PF11976.8 ORX45265.1 - 1.7e-23 82.2 0.0 2.1e-23 82.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX45265.1 - 9.3e-11 41.3 0.0 1.3e-10 40.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family NADH_B2 PF14813.6 ORX45266.1 - 4e-05 23.3 0.8 6.8e-05 22.6 0.8 1.4 1 0 0 1 1 1 1 NADH dehydrogenase 1 beta subcomplex subunit 2 Ribosomal_L14 PF00238.19 ORX45267.1 - 2e-36 124.7 0.1 2.4e-36 124.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ion_trans PF00520.31 ORX45268.1 - 1.4e-26 93.3 21.9 1.9e-26 92.8 21.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ORX45268.1 - 3.3e-10 39.8 11.5 3.3e-10 39.8 11.5 2.6 2 1 1 3 3 3 1 Ion channel Lig_chan PF00060.26 ORX45268.1 - 0.22 11.3 5.8 0.17 11.7 0.4 2.4 2 0 0 2 2 2 0 Ligand-gated ion channel Pyr_redox_2 PF07992.14 ORX45270.1 - 2.9e-40 138.3 0.0 5e-40 137.6 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske_2 PF13806.6 ORX45270.1 - 1.8e-22 79.2 0.0 5.3e-22 77.7 0.0 1.8 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NIR_SIR PF01077.22 ORX45270.1 - 6.7e-15 55.0 0.0 1.2e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Nitrite and sulphite reductase 4Fe-4S domain Rieske PF00355.26 ORX45270.1 - 4.3e-14 52.2 0.0 9.3e-14 51.1 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Fer2_BFD PF04324.15 ORX45270.1 - 2.2e-13 50.3 13.2 2.5e-12 47.0 8.5 2.8 2 0 0 2 2 2 1 BFD-like [2Fe-2S] binding domain Rubredoxin_C PF18267.1 ORX45270.1 - 5.6e-13 48.6 1.4 1.1e-11 44.5 0.1 3.6 4 0 0 4 4 4 1 Rubredoxin NAD+ reductase C-terminal domain Pyr_redox PF00070.27 ORX45270.1 - 3.2e-11 43.6 0.5 2.3e-09 37.7 0.1 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NIR_SIR_ferr PF03460.17 ORX45270.1 - 5e-09 35.9 0.0 1e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Nitrite/Sulfite reductase ferredoxin-like half domain AlaDh_PNT_C PF01262.21 ORX45270.1 - 0.0017 17.7 0.1 0.0035 16.7 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_8 PF13450.6 ORX45270.1 - 0.0017 18.5 0.0 0.0058 16.8 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX45270.1 - 0.0025 17.5 0.0 0.48 9.9 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ORX45270.1 - 0.0026 16.9 0.4 1.9 7.5 0.1 2.2 2 0 0 2 2 2 2 FAD binding domain GIDA PF01134.22 ORX45270.1 - 0.0035 16.5 0.1 0.013 14.6 0.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ORX45270.1 - 0.0057 16.0 0.3 0.55 9.4 0.1 2.8 2 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX45270.1 - 0.23 11.4 0.4 21 5.1 0.0 3.5 4 0 0 4 4 4 0 FAD-NAD(P)-binding Oxidored_molyb PF00174.19 ORX45271.1 - 1.3e-61 207.2 0.0 2.7e-61 206.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ORX45271.1 - 1e-43 148.7 0.1 2.1e-43 147.6 0.1 1.6 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 ORX45271.1 - 3.7e-21 75.0 0.1 6.8e-21 74.2 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FAD_binding_6 PF00970.24 ORX45271.1 - 3.6e-20 72.1 0.0 6.1e-20 71.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ORX45271.1 - 5.9e-11 43.0 0.0 3.3e-10 40.6 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ORX45271.1 - 0.036 14.2 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 Ferric reductase NAD binding domain MFS_1 PF07690.16 ORX45272.1 - 1.2e-30 106.6 19.8 1.2e-30 106.6 19.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX45272.1 - 3.3e-06 25.7 1.4 4.6e-06 25.2 0.0 1.8 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family FMN_red PF03358.15 ORX45273.1 - 1.6e-17 63.7 0.0 2.3e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX45273.1 - 1.5e-09 37.9 0.0 1.9e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX45273.1 - 0.0028 17.9 0.1 0.21 11.8 0.1 2.7 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX45273.1 - 0.099 12.9 0.0 0.17 12.2 0.0 1.5 1 1 0 1 1 1 0 Flavodoxin domain MFS_1 PF07690.16 ORX45274.1 - 1e-41 143.1 23.2 1e-41 143.1 23.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_3 PF05977.13 ORX45274.1 - 0.00016 20.2 1.4 0.0003 19.3 1.4 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector Herpes_BLRF2 PF05812.12 ORX45275.1 - 0.0085 16.2 18.0 0.053 13.7 4.6 3.4 2 2 1 3 3 3 2 Herpesvirus BLRF2 protein EzrA PF06160.12 ORX45275.1 - 0.043 12.0 22.3 0.017 13.3 10.4 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 ORX45275.1 - 0.057 12.8 19.7 0.14 11.5 19.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec8_exocyst PF04048.14 ORX45275.1 - 0.095 12.6 15.6 0.49 10.3 3.8 2.5 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain APG6_N PF17675.1 ORX45275.1 - 0.2 12.2 27.1 0.41 11.2 11.0 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Bacillus_HBL PF05791.11 ORX45275.1 - 0.26 11.1 11.1 1.1 9.1 4.4 2.3 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) FapA PF03961.13 ORX45275.1 - 0.35 9.4 17.6 0.089 11.4 5.2 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A YabA PF06156.13 ORX45275.1 - 0.43 11.2 18.5 1.3 9.7 7.3 2.9 2 1 1 3 3 3 0 Initiation control protein YabA CENP-H PF05837.12 ORX45275.1 - 0.72 10.3 29.4 0.044 14.2 12.2 2.4 2 1 0 2 2 2 0 Centromere protein H (CENP-H) CdvA PF18822.1 ORX45275.1 - 0.75 9.6 20.3 0.098 12.5 6.0 3.3 2 2 1 3 3 3 0 CdvA-like coiled-coil domain FAM184 PF15665.5 ORX45275.1 - 0.8 9.4 27.7 2.2 8.0 7.6 2.2 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B OmpH PF03938.14 ORX45275.1 - 1.2 9.5 34.7 4 7.8 17.7 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) CREPT PF16566.5 ORX45275.1 - 1.5 9.0 21.2 0.28 11.3 7.8 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 ORX45275.1 - 2.2 8.3 42.6 1.8 8.6 14.0 3.2 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Uso1_p115_C PF04871.13 ORX45275.1 - 2.6 8.4 26.9 5.4 7.4 15.5 2.7 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Rit1_C PF17184.4 ORX45275.1 - 2.9 7.2 7.5 4.4 6.7 2.3 2.1 2 0 0 2 2 2 0 Rit1 N-terminal domain betaPIX_CC PF16523.5 ORX45275.1 - 3.5 7.5 24.5 0.2 11.5 6.7 3.9 2 2 1 3 3 3 0 betaPIX coiled coil HAUS-augmin3 PF14932.6 ORX45275.1 - 4.9 6.7 25.3 3.5 7.1 10.1 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Prominin PF05478.11 ORX45275.1 - 5.1 4.9 14.5 3 5.7 7.7 2.1 2 0 0 2 2 2 0 Prominin ANAPC4 PF12896.7 ORX45275.1 - 5.6 6.4 14.2 0.44 10.0 3.5 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 DUF2951 PF11166.8 ORX45275.1 - 7.2 6.9 12.1 2.1 8.6 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) GLTP PF08718.11 ORX45275.1 - 7.7 6.8 11.9 12 6.1 3.4 2.3 2 0 0 2 2 2 0 Glycolipid transfer protein (GLTP) DUF3584 PF12128.8 ORX45275.1 - 8.1 3.8 28.6 2.6 5.4 14.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Kinesin PF00225.23 ORX45276.1 - 2.4e-102 342.3 0.0 3.1e-102 341.9 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX45276.1 - 5e-23 81.7 0.0 8.9e-23 80.9 0.0 1.4 1 0 0 1 1 1 1 Microtubule binding GAS PF13851.6 ORX45276.1 - 0.003 16.9 2.6 0.003 16.9 2.6 1.9 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding AAA_16 PF13191.6 ORX45276.1 - 0.0055 17.1 2.1 0.011 16.1 0.2 2.4 1 1 1 2 2 2 1 AAA ATPase domain KBP_C PF12309.8 ORX45276.1 - 0.013 15.0 0.9 4.1 6.8 1.1 2.7 2 1 0 2 2 2 0 KIF-1 binding protein C terminal DUF87 PF01935.17 ORX45276.1 - 0.2 11.7 2.0 16 5.5 0.0 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain ThrE PF06738.12 ORX45277.1 - 4e-56 190.1 16.0 1.2e-50 172.2 1.8 2.0 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX45277.1 - 6.3e-11 42.5 6.2 6.3e-11 42.5 6.2 2.3 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE DDE_3 PF13358.6 ORX45278.1 - 0.00079 19.2 0.0 0.00083 19.1 0.0 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease DotU PF09850.9 ORX45278.1 - 0.042 13.6 0.0 0.044 13.5 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system protein DotU Band_7 PF01145.25 ORX45279.1 - 8.6e-29 100.8 1.8 1.6e-28 99.9 1.8 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 ORX45279.1 - 5.4e-26 90.4 2.3 5.4e-26 90.4 2.3 2.0 2 0 0 2 2 2 1 C-terminal region of band_7 DUF4766 PF15973.5 ORX45279.1 - 0.065 13.8 1.2 0.083 13.5 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4766) DNA_pol_A_exo1 PF01612.20 ORX45280.1 - 1.2e-20 74.0 0.0 1.6e-20 73.6 0.0 1.1 1 0 0 1 1 1 1 3'-5' exonuclease Ysc84 PF04366.12 ORX45281.1 - 3e-43 146.6 1.3 4.5e-43 146.1 1.3 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ORX45281.1 - 2.9e-15 55.6 0.1 6.2e-15 54.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX45281.1 - 7.1e-12 44.8 0.0 1.4e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX45281.1 - 7.1e-11 41.8 0.0 1.5e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SCP2 PF02036.17 ORX45282.1 - 4.4e-12 46.4 0.4 5.9e-12 46.0 0.4 1.2 1 0 0 1 1 1 1 SCP-2 sterol transfer family Y_phosphatase3 PF13350.6 ORX45283.1 - 5.8e-56 190.1 0.0 9.1e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Abhydrolase_1 PF00561.20 ORX45283.1 - 1.4e-11 44.5 0.1 3.6e-09 36.6 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX45283.1 - 8.7e-10 38.3 0.1 2e-07 30.5 0.0 2.2 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX45283.1 - 1.8e-06 28.8 0.1 7.3e-06 26.7 0.0 2.0 2 1 0 2 2 2 1 Alpha/beta hydrolase family Y_phosphatase PF00102.27 ORX45283.1 - 0.00078 19.1 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Abhydrolase_2 PF02230.16 ORX45283.1 - 0.00091 19.1 0.4 7.4 6.3 0.0 3.3 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase DUF1057 PF06342.12 ORX45283.1 - 0.04 13.0 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S9 PF00326.21 ORX45283.1 - 0.081 12.4 0.1 0.3 10.5 0.1 1.9 1 1 0 1 1 1 0 Prolyl oligopeptidase family DUF1749 PF08538.10 ORX45283.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Y_phosphatase2 PF03162.13 ORX45283.1 - 0.18 11.4 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Svf1_C PF17187.4 ORX45285.1 - 1.4e-49 168.1 1.4 2.3e-49 167.4 1.4 1.4 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 ORX45285.1 - 7.1e-39 133.5 0.4 1.3e-38 132.6 0.4 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain WD40 PF00400.32 ORX45286.1 - 8.4e-11 42.3 13.3 0.0015 19.4 0.1 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX45286.1 - 4.5e-07 30.1 0.1 0.0097 16.2 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX45286.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Kelch_4 PF13418.6 ORX45287.1 - 1.2e-13 50.8 8.3 9.2e-08 32.0 0.0 6.4 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX45287.1 - 6.2e-10 38.5 5.0 1e-06 28.2 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ORX45287.1 - 1.2e-08 34.9 13.1 1.6e-05 25.0 0.1 6.0 5 1 1 6 6 6 2 Kelch motif Kelch_5 PF13854.6 ORX45287.1 - 3.5e-07 30.1 2.6 0.00014 21.8 0.0 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ORX45287.1 - 4.6e-07 30.0 16.9 0.002 18.4 0.3 5.9 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX45287.1 - 2.2e-06 27.4 1.3 0.00032 20.6 0.0 4.3 6 0 0 6 6 6 1 Kelch motif ASC PF00858.24 ORX45287.1 - 0.0025 16.8 1.5 1.3 8.0 0.0 2.2 2 0 0 2 2 2 2 Amiloride-sensitive sodium channel Asp PF00026.23 ORX45288.1 - 2.4e-25 89.6 0.0 5.2e-13 49.1 0.0 2.7 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX45288.1 - 5e-06 26.9 0.1 7.8e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Dus PF01207.17 ORX45289.1 - 6.9e-68 229.0 0.0 7.8e-68 228.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 ORX45289.1 - 7.6e-06 25.4 0.0 1.2e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase His_biosynth PF00977.21 ORX45289.1 - 1.5e-05 24.6 0.0 2.8e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 Histidine biosynthesis protein NMO PF03060.15 ORX45289.1 - 0.00094 18.7 0.0 0.0029 17.0 0.0 1.7 1 1 1 2 2 2 1 Nitronate monooxygenase DHO_dh PF01180.21 ORX45289.1 - 0.0011 18.2 0.0 0.24 10.6 0.0 2.1 1 1 0 1 1 1 1 Dihydroorotate dehydrogenase Oxidored_FMN PF00724.20 ORX45289.1 - 0.19 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 NADH:flavin oxidoreductase / NADH oxidase family RTC PF01137.21 ORX45290.1 - 1.7e-59 200.7 0.0 1.9e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ORX45290.1 - 6.6e-38 129.4 0.0 1.1e-37 128.6 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Ras PF00071.22 ORX45291.1 - 1.1e-58 197.4 0.3 1.3e-58 197.2 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX45291.1 - 1.1e-33 116.0 0.1 1.6e-33 115.5 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX45291.1 - 8e-18 64.5 0.1 9.5e-18 64.3 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX45291.1 - 4.7e-08 33.1 0.1 7e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX45291.1 - 2e-07 30.6 0.0 2.4e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX45291.1 - 2.2e-06 27.4 0.2 9.2e-06 25.3 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX45291.1 - 0.00019 20.9 0.1 0.00044 19.7 0.1 1.6 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ORX45291.1 - 0.0042 17.0 0.1 0.48 10.3 0.0 2.4 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 ORX45291.1 - 0.008 15.7 0.0 0.17 11.4 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B TniB PF05621.11 ORX45291.1 - 0.01 15.2 0.0 0.021 14.2 0.0 1.5 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 ORX45291.1 - 0.011 15.5 0.2 0.017 14.8 0.2 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ORX45291.1 - 0.029 13.6 0.1 0.054 12.8 0.1 1.4 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 ORX45291.1 - 0.079 12.1 1.8 2.7 7.1 0.2 2.1 1 1 1 2 2 2 0 G-protein alpha subunit Gti1_Pac2 PF09729.9 ORX45292.1 - 2.1e-55 187.6 0.6 4e-41 141.1 0.1 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family 14-3-3 PF00244.20 ORX45293.1 - 1.9e-105 351.3 2.2 2.1e-105 351.1 2.2 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 ORX45293.1 - 0.0033 17.4 0.1 0.0075 16.3 0.1 1.6 1 0 0 1 1 1 1 Flagellar protein FlaF OPT PF03169.15 ORX45294.1 - 3.5e-152 508.2 24.6 4e-152 508.0 24.6 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3899 PF13038.6 ORX45294.1 - 6.6 7.3 0.0 6.6 7.3 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3899) Ribosomal_S10 PF00338.22 ORX45295.1 - 9.3e-33 112.4 0.0 1.5e-32 111.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e ACOX PF01756.19 ORX45296.1 - 1.4e-53 181.1 0.7 2.7e-53 180.2 0.7 1.5 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX45296.1 - 4.7e-25 88.6 0.3 8.9e-25 87.7 0.3 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX45296.1 - 1.2e-12 47.8 0.0 2.5e-12 46.8 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ORX45296.1 - 3.4e-06 27.3 0.2 6.5e-05 23.2 0.0 2.8 2 1 0 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Actin PF00022.19 ORX45297.1 - 4.4e-44 150.7 0.0 1.8e-23 82.8 0.0 2.2 2 0 0 2 2 2 2 Actin Noggin PF05806.12 ORX45297.1 - 0.016 15.1 5.3 0.038 13.9 5.3 1.6 1 0 0 1 1 1 0 Noggin PilM_2 PF11104.8 ORX45297.1 - 0.017 14.1 1.0 0.61 9.1 0.0 2.9 2 1 1 3 3 3 0 Type IV pilus assembly protein PilM; NIF PF03031.18 ORX45298.1 - 6.5e-41 139.7 0.0 8e-41 139.4 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 ORX45298.1 - 0.0045 17.4 0.4 0.042 14.3 0.3 2.2 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Sigma_1_2 PF03084.14 ORX45299.1 - 0.076 12.3 0.7 0.11 11.8 0.7 1.3 1 1 0 1 1 1 0 Reoviral Sigma1/Sigma2 family DUF148 PF02520.17 ORX45299.1 - 0.1 12.7 1.7 0.14 12.3 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF148 CorA PF01544.18 ORX45299.1 - 0.13 11.5 1.4 0.56 9.5 0.1 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DNA_pol_E_B PF04042.16 ORX45301.1 - 3.1e-38 131.2 2.7 3.1e-38 131.2 2.7 1.8 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 ORX45301.1 - 8.8e-31 107.7 3.3 1.3e-30 107.2 3.3 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal MbeB_N PF04837.12 ORX45301.1 - 0.11 12.9 0.8 3.4 8.1 0.1 2.7 2 0 0 2 2 2 0 MbeB-like, N-term conserved region PrmA PF06325.13 ORX45302.1 - 8.8e-14 51.6 0.0 1.5e-13 50.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 ORX45302.1 - 4.4e-13 49.3 0.0 9.8e-13 48.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX45302.1 - 7.1e-13 49.1 0.0 2.1e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX45302.1 - 1.6e-11 44.7 0.0 4.6e-11 43.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX45302.1 - 8e-08 32.0 0.2 1.5e-07 31.2 0.2 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX45302.1 - 1.5e-06 28.1 0.0 2.9e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX45302.1 - 6e-06 26.3 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX45302.1 - 3.6e-05 24.4 0.1 0.00015 22.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 ORX45302.1 - 0.00035 20.3 0.1 0.00068 19.4 0.1 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 TehB PF03848.14 ORX45302.1 - 0.0012 18.3 0.0 0.0022 17.4 0.0 1.5 1 0 0 1 1 1 1 Tellurite resistance protein TehB Met_10 PF02475.16 ORX45302.1 - 0.0018 18.1 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_9 PF08003.11 ORX45302.1 - 0.0053 15.7 0.0 0.0084 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.19 ORX45302.1 - 0.0071 16.1 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 ORX45302.1 - 0.012 15.4 0.1 0.027 14.2 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase Ubie_methyltran PF01209.18 ORX45302.1 - 0.019 14.3 0.1 0.03 13.7 0.1 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 ORX45302.1 - 0.021 14.8 0.0 0.04 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PRMT5 PF05185.16 ORX45302.1 - 0.023 14.6 0.3 0.041 13.7 0.0 1.5 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase zf-C2H2_2 PF12756.7 ORX45302.1 - 0.023 15.0 0.7 0.073 13.4 0.5 2.0 2 0 0 2 2 1 0 C2H2 type zinc-finger (2 copies) Cons_hypoth95 PF03602.15 ORX45302.1 - 0.028 14.1 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 CMAS PF02353.20 ORX45302.1 - 0.059 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_24 PF13578.6 ORX45302.1 - 0.069 14.2 0.0 0.17 12.9 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain p450 PF00067.22 ORX45303.1 - 5.3e-86 289.2 0.0 6.1e-86 289.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 HA2 PF04408.23 ORX45304.1 - 3.1e-11 43.5 0.1 4.9e-11 42.9 0.1 1.3 1 1 0 1 1 1 1 Helicase associated domain (HA2) OSR1_C PF12202.8 ORX45306.1 - 0.045 14.0 0.2 0.12 12.6 0.2 1.7 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain HA2 PF04408.23 ORX45307.1 - 3.5e-24 85.2 0.0 6.5e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ORX45307.1 - 1e-15 58.0 0.0 2.6e-15 56.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ORX45307.1 - 3.1e-13 49.9 0.0 7.3e-13 48.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 ORX45307.1 - 2.5e-10 40.4 0.3 4.8e-10 39.5 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX45307.1 - 7.7e-07 29.5 0.6 2.7e-06 27.7 0.1 2.1 3 0 0 3 3 3 1 AAA domain AAA_19 PF13245.6 ORX45307.1 - 0.00025 21.4 0.5 0.00054 20.3 0.5 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ORX45307.1 - 0.0058 16.7 0.6 0.03 14.3 0.6 2.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ORX45307.1 - 0.0069 16.9 0.9 0.5 10.9 0.9 2.4 1 1 0 1 1 1 1 ABC transporter AAA_30 PF13604.6 ORX45307.1 - 0.0093 15.7 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ORX45307.1 - 0.026 14.0 0.0 0.078 12.4 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein FtsK_SpoIIIE PF01580.18 ORX45307.1 - 0.027 13.8 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family T2SSE PF00437.20 ORX45307.1 - 0.029 13.4 0.1 0.05 12.7 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Flavi_DEAD PF07652.14 ORX45307.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_7 PF12775.7 ORX45307.1 - 0.081 12.4 0.1 0.23 10.9 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_membrane PF00664.23 ORX45308.1 - 1.1e-110 369.6 31.2 4e-59 200.5 14.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX45308.1 - 2.9e-67 225.4 0.3 3.6e-33 115.0 0.1 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX45308.1 - 3.2e-15 56.2 0.0 9.5e-07 28.5 0.1 3.5 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ORX45308.1 - 1.8e-07 31.5 2.4 0.04 14.2 0.2 3.7 2 2 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ORX45308.1 - 2.1e-06 27.8 0.0 0.022 14.7 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ORX45308.1 - 5.9e-06 25.9 1.3 0.14 12.0 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX45308.1 - 2.6e-05 24.7 5.8 0.19 12.1 1.7 3.4 2 2 0 2 2 2 2 AAA ATPase domain Zeta_toxin PF06414.12 ORX45308.1 - 4.8e-05 22.7 3.7 0.019 14.3 0.0 3.4 4 0 0 4 4 4 2 Zeta toxin APS_kinase PF01583.20 ORX45308.1 - 4.9e-05 23.3 0.4 0.074 12.9 0.1 3.3 3 0 0 3 3 3 1 Adenylylsulphate kinase AAA PF00004.29 ORX45308.1 - 0.00012 22.5 3.7 0.51 10.8 0.1 3.8 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) ABC_ATPase PF09818.9 ORX45308.1 - 0.0002 20.3 2.8 0.18 10.5 0.0 3.7 4 1 0 4 4 4 2 Predicted ATPase of the ABC class AAA_33 PF13671.6 ORX45308.1 - 0.00037 20.7 0.3 0.19 11.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX45308.1 - 0.0011 18.5 0.1 1.3 8.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region SbcCD_C PF13558.6 ORX45308.1 - 0.0012 19.0 4.0 0.99 9.7 0.5 3.9 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 ORX45308.1 - 0.0021 18.4 0.2 15 6.0 0.0 4.0 3 0 0 3 3 3 0 RNA helicase AAA_30 PF13604.6 ORX45308.1 - 0.0024 17.6 5.1 1.5 8.5 0.4 3.6 2 2 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ORX45308.1 - 0.0028 17.4 0.1 0.63 9.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain G-alpha PF00503.20 ORX45308.1 - 0.0031 16.8 0.1 0.33 10.1 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_5 PF07728.14 ORX45308.1 - 0.0031 17.5 0.7 1.2 9.1 0.0 3.8 4 0 0 4 4 3 1 AAA domain (dynein-related subfamily) SRP54 PF00448.22 ORX45308.1 - 0.0035 17.0 0.7 2.5 7.7 0.1 2.6 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain AAA_18 PF13238.6 ORX45308.1 - 0.0041 17.7 0.1 0.19 12.3 0.0 2.8 3 0 0 3 3 2 1 AAA domain DUF87 PF01935.17 ORX45308.1 - 0.005 17.0 0.2 0.66 10.0 0.1 3.0 3 0 0 3 3 3 1 Helicase HerA, central domain MMR_HSR1 PF01926.23 ORX45308.1 - 0.0053 16.8 0.0 2.2 8.4 0.0 3.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_25 PF13481.6 ORX45308.1 - 0.0072 15.9 0.1 3 7.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_15 PF13175.6 ORX45308.1 - 0.01 15.6 0.0 0.31 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_21 PF13304.6 ORX45308.1 - 0.019 14.8 0.1 1.3 8.7 0.0 3.1 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_28 PF13521.6 ORX45308.1 - 0.026 14.8 0.4 1.3 9.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 ORX45308.1 - 0.032 13.9 0.2 4.2 7.0 0.0 2.8 3 0 0 3 3 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PRK PF00485.18 ORX45308.1 - 0.067 12.9 0.1 6.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 ORX45308.1 - 0.11 12.4 0.4 6.3 6.7 0.1 2.7 2 0 0 2 2 2 0 NACHT domain Sod_Fe_C PF02777.18 ORX45310.1 - 0.0059 16.8 0.0 0.0066 16.6 0.0 1.0 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Pkinase PF00069.25 ORX45311.1 - 5.3e-46 157.1 0.0 2.6e-23 82.7 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45311.1 - 6.1e-12 45.4 0.0 4.6e-09 35.9 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX45311.1 - 5e-06 25.6 0.0 1.6e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX45311.1 - 0.00059 19.8 0.1 0.0018 18.2 0.0 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX45311.1 - 0.014 14.8 0.3 0.028 13.8 0.3 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ORX45311.1 - 0.084 12.4 0.1 0.15 11.7 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kinase-like PF14531.6 ORX45311.1 - 0.088 12.1 0.0 14 4.9 0.0 2.2 2 0 0 2 2 2 0 Kinase-like SPESP1 PF15754.5 ORX45311.1 - 0.4 9.8 15.6 1.2 8.2 15.6 1.8 1 1 0 1 1 1 0 Sperm equatorial segment protein 1 SPX PF03105.19 ORX45311.1 - 2.4 8.0 11.9 3.5 7.4 0.3 2.2 2 0 0 2 2 2 0 SPX domain UPF0020 PF01170.18 ORX45312.1 - 5.4e-05 23.0 0.0 0.0007 19.3 0.0 2.4 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 ORX45312.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.4 1 0 0 1 1 1 0 N-6 DNA Methylase AMP-binding PF00501.28 ORX45313.1 - 4.1e-74 249.7 0.0 5.3e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX45313.1 - 2.5e-06 28.4 0.0 4.8e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain CLTH PF10607.9 ORX45314.1 - 3.4e-27 95.1 0.0 6e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 ORX45314.1 - 2.4e-21 76.1 0.3 4.2e-21 75.3 0.3 1.4 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 ORX45314.1 - 0.027 14.4 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 LisH SPT2 PF08243.11 ORX45314.1 - 1.7 9.2 7.9 0.11 13.0 2.4 1.7 2 0 0 2 2 2 0 SPT2 chromatin protein Ribosomal_S7 PF00177.21 ORX45315.1 - 8.3e-35 119.6 1.7 9.9e-35 119.4 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e mRNA_stabil PF13929.6 ORX45315.1 - 0.045 12.7 0.1 0.2 10.6 0.0 1.8 1 1 1 2 2 2 0 mRNA stabilisation ATP_bind_1 PF03029.17 ORX45316.1 - 4.7e-86 288.5 0.1 5.4e-86 288.3 0.1 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_33 PF13671.6 ORX45316.1 - 7.7e-05 22.9 0.0 0.0003 21.0 0.0 1.9 2 1 0 2 2 2 1 AAA domain CLP1_P PF16575.5 ORX45316.1 - 0.00037 20.3 0.0 0.036 13.9 0.0 2.2 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MeaB PF03308.16 ORX45316.1 - 0.0053 15.8 0.0 0.011 14.7 0.0 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 ORX45316.1 - 0.0065 16.9 0.0 0.019 15.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 ORX45316.1 - 0.012 15.5 0.0 0.093 12.6 0.0 2.2 3 0 0 3 3 3 0 NTPase CbiA PF01656.23 ORX45316.1 - 0.019 15.0 0.0 0.025 14.6 0.0 1.5 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 ORX45316.1 - 0.019 14.7 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_31 PF13614.6 ORX45316.1 - 0.021 14.7 0.0 0.71 9.8 0.0 2.3 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX45316.1 - 0.046 13.4 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX45316.1 - 0.069 12.7 0.0 1.4 8.5 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 ORX45316.1 - 0.16 11.6 0.0 0.31 10.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 ORX45316.1 - 0.21 11.7 0.1 4.1 7.5 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_17 PF13207.6 ORX45316.1 - 0.21 12.0 0.2 0.59 10.5 0.2 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX45316.1 - 0.26 11.8 0.5 0.8 10.3 0.5 2.1 1 1 0 1 1 1 0 AAA domain Torus PF16131.5 ORX45318.1 - 6.7e-08 33.2 0.1 1.3e-07 32.2 0.1 1.5 1 0 0 1 1 1 1 Torus domain zf_CCCH_4 PF18345.1 ORX45318.1 - 8.2e-06 25.7 3.0 8.2e-06 25.7 3.0 2.2 2 0 0 2 2 2 1 Zinc finger domain RRM_1 PF00076.22 ORX45318.1 - 0.00088 19.1 0.2 0.029 14.2 0.1 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 ORX45318.1 - 0.0026 17.6 3.8 0.0026 17.6 3.8 2.9 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ORX45318.1 - 0.0039 17.4 0.2 0.013 15.7 0.2 1.9 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 ORX45318.1 - 0.0052 16.6 3.3 0.012 15.4 3.3 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX45318.1 - 0.041 14.4 1.4 0.041 14.4 1.4 2.4 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger FYVE PF01363.21 ORX45318.1 - 0.56 10.4 7.7 0.2 11.8 4.3 2.1 2 1 0 2 2 2 0 FYVE zinc finger MCM PF00493.23 ORX45319.1 - 1.2e-96 322.1 0.0 1.9e-96 321.5 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX45319.1 - 4.2e-37 126.8 0.4 7.9e-37 125.9 0.4 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX45319.1 - 1.1e-29 102.6 1.7 2.3e-29 101.6 1.7 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX45319.1 - 3.9e-14 53.1 0.5 2.3e-13 50.6 0.3 2.4 2 0 0 2 2 2 1 MCM N-terminal domain AAA_5 PF07728.14 ORX45319.1 - 7.5e-08 32.5 0.0 3e-07 30.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ORX45319.1 - 1.4e-06 27.9 0.0 0.002 17.6 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ORX45319.1 - 0.00037 20.9 2.2 0.0023 18.4 0.1 3.0 2 2 0 2 2 2 1 AAA ATPase domain Sigma54_activat PF00158.26 ORX45319.1 - 0.00062 19.5 0.0 1.9 8.2 0.0 3.0 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_3 PF07726.11 ORX45319.1 - 0.00071 19.4 0.0 0.022 14.6 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CRISPR_Cse2 PF09485.10 ORX45319.1 - 2.3 8.7 5.3 82 3.7 5.1 2.7 2 1 0 2 2 2 0 CRISPR-associated protein Cse2 (CRISPR_cse2) GATA PF00320.27 ORX45320.1 - 4.1e-16 58.3 1.9 8.4e-16 57.3 1.9 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 ORX45320.1 - 3.5e-14 52.3 1.0 6.7e-14 51.4 1.0 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) eIF-3_zeta PF05091.12 ORX45323.1 - 1.9e-08 33.7 1.7 2.3e-08 33.5 1.7 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) eIF-3_zeta PF05091.12 ORX45327.1 - 1.4e-193 644.6 7.9 1.6e-193 644.4 7.9 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NARG2_C PF10505.9 ORX45327.1 - 0.01 15.3 0.0 0.22 11.0 0.0 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus DUF3293 PF11697.8 ORX45327.1 - 4.4 7.9 6.5 0.67 10.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3293) Snapin_Pallidin PF14712.6 ORX45328.1 - 1.2e-16 60.9 3.9 1.3e-16 60.7 3.9 1.0 1 0 0 1 1 1 1 Snapin/Pallidin DUF4795 PF16043.5 ORX45328.1 - 0.0075 15.9 1.1 0.0092 15.6 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) Nup54 PF13874.6 ORX45328.1 - 0.0078 16.3 1.3 0.0086 16.2 1.3 1.1 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 MCPsignal PF00015.21 ORX45328.1 - 0.011 15.5 0.9 0.016 15.0 0.9 1.3 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain NBD94 PF16830.5 ORX45328.1 - 0.019 15.4 2.0 3 8.3 0.0 2.4 3 0 0 3 3 3 0 Nucleotide-Binding Domain 94 of RH Baculo_PEP_C PF04513.12 ORX45328.1 - 0.019 15.0 3.0 0.031 14.3 3.0 1.4 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Zw10 PF06248.13 ORX45328.1 - 0.049 12.2 0.8 0.053 12.1 0.8 1.0 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 KxDL PF10241.9 ORX45328.1 - 0.087 13.1 3.7 0.19 12.0 3.7 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein DUF1664 PF07889.12 ORX45328.1 - 0.16 12.0 3.2 0.93 9.5 3.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Flagellin_N PF00669.20 ORX45328.1 - 0.18 11.9 4.9 2.6 8.2 0.3 2.2 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region DUF948 PF06103.11 ORX45328.1 - 0.23 11.8 3.6 2.7 8.3 1.5 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) HIP1_clath_bdg PF16515.5 ORX45328.1 - 0.36 11.5 5.2 2.6 8.7 5.2 1.9 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DivIC PF04977.15 ORX45328.1 - 0.4 10.5 8.6 0.77 9.6 2.4 2.2 1 1 1 2 2 2 0 Septum formation initiator ABC_tran_CTD PF16326.5 ORX45328.1 - 0.92 9.8 6.4 3.9 7.8 0.9 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF4807 PF16065.5 ORX45329.1 - 2.8e-19 69.0 1.3 4.1e-19 68.5 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4807) Methyltransf_11 PF08241.12 ORX45330.1 - 2.7e-05 24.7 0.0 5.6e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX45330.1 - 7.3e-05 23.4 0.0 0.00017 22.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ORX45330.1 - 0.0002 21.2 0.2 0.00032 20.5 0.2 1.2 1 0 0 1 1 1 1 Met-10+ like-protein DOT1 PF08123.13 ORX45330.1 - 0.00049 19.7 1.1 0.0047 16.5 1.1 2.1 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 ORX45330.1 - 0.002 18.9 0.0 0.0046 17.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX45330.1 - 0.02 14.8 0.2 0.037 13.9 0.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain CheR PF01739.18 ORX45330.1 - 0.034 13.6 0.1 0.056 12.9 0.1 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain UPF0020 PF01170.18 ORX45330.1 - 0.098 12.3 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Abhydrolase_6 PF12697.7 ORX45331.1 - 3.5e-14 53.9 0.0 6e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX45331.1 - 5e-13 48.9 0.0 7e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX45331.1 - 7.8e-08 32.3 0.0 1.2e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ORX45331.1 - 0.00048 20.0 0.0 0.00063 19.7 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX45331.1 - 0.00064 19.3 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 ORX45331.1 - 0.0083 16.1 0.2 6.4 6.6 0.0 3.1 2 1 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Thioesterase PF00975.20 ORX45331.1 - 0.026 14.6 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_2 PF02230.16 ORX45331.1 - 0.036 13.8 0.0 3.6 7.3 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 ORX45331.1 - 0.11 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein F-box-like PF12937.7 ORX45332.1 - 0.011 15.6 2.1 0.024 14.5 2.1 1.6 1 0 0 1 1 1 0 F-box-like DASH_Dam1 PF08653.10 ORX45332.1 - 0.075 12.9 0.1 0.18 11.7 0.1 1.7 1 0 0 1 1 1 0 DASH complex subunit Dam1 WD40 PF00400.32 ORX45333.1 - 5e-19 68.3 14.3 0.00055 20.7 0.1 9.9 10 0 0 10 10 10 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX45333.1 - 9.8e-15 54.6 0.2 0.0025 18.1 0.0 5.9 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX45333.1 - 0.0034 16.4 0.0 0.072 12.0 0.0 2.8 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ACBP PF00887.19 ORX45334.1 - 1.5e-27 95.6 0.6 4.5e-27 94.1 0.3 1.8 2 0 0 2 2 2 1 Acyl CoA binding protein Ank_4 PF13637.6 ORX45334.1 - 1e-25 89.8 6.1 8.9e-14 51.7 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX45334.1 - 3e-25 88.6 6.4 1.6e-13 51.0 0.8 2.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX45334.1 - 3.4e-17 62.3 0.2 2.6e-08 34.0 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX45334.1 - 6.1e-14 51.7 2.1 2.7e-06 27.5 0.3 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ORX45334.1 - 2.9e-12 45.6 0.8 1.6e-05 24.9 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat PTE PF02126.18 ORX45334.1 - 0.00046 19.7 0.2 0.00063 19.3 0.2 1.2 1 0 0 1 1 1 1 Phosphotriesterase family ATP-synt_ab_Xtn PF16886.5 ORX45336.1 - 0.24 11.3 0.0 0.47 10.3 0.0 1.4 1 0 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension ETRAMP PF09716.10 ORX45338.1 - 0.044 13.8 0.2 0.044 13.8 0.2 3.2 3 1 1 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) Ala_racemase_N PF01168.20 ORX45456.1 - 9.7e-27 94.0 0.0 1.1e-26 93.8 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DHQS PF01959.16 ORX45456.1 - 0.013 14.4 0.1 0.023 13.6 0.1 1.4 1 0 0 1 1 1 0 3-dehydroquinate synthase II GHL10 PF02638.15 ORX45456.1 - 0.14 11.2 0.1 0.17 10.9 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 Elong_Iki1 PF10483.9 ORX45457.1 - 7.8e-30 104.4 0.0 8.7e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 DIOX_N PF14226.6 ORX45458.1 - 2e-21 76.9 1.0 7.4e-21 75.1 0.1 2.1 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ORX45458.1 - 3.3e-14 53.2 0.1 5.9e-14 52.4 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TauD PF02668.16 ORX45458.1 - 0.0086 15.9 0.2 3.1 7.5 0.0 2.2 2 0 0 2 2 2 2 Taurine catabolism dioxygenase TauD, TfdA family DUF1281_C PF18406.1 ORX45458.1 - 0.14 11.9 0.8 3.1 7.6 0.1 2.3 2 0 0 2 2 2 0 Ferredoxin-like domain in Api92-like protein AAA PF00004.29 ORX45459.1 - 4.1e-39 134.0 0.0 7.2e-39 133.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX45459.1 - 4.9e-18 64.7 0.0 2.8e-10 39.9 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX45459.1 - 3.3e-08 34.1 0.9 1.9e-05 25.2 0.0 3.3 1 1 2 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX45459.1 - 9e-07 29.2 0.3 0.017 15.4 0.0 3.9 2 1 1 3 3 3 1 AAA domain Rad17 PF03215.15 ORX45459.1 - 0.00027 20.9 0.0 0.00057 19.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain RNA_helicase PF00910.22 ORX45459.1 - 0.00087 19.7 0.0 0.002 18.5 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 ORX45459.1 - 0.0014 18.7 0.0 0.0035 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ORX45459.1 - 0.002 17.4 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 ORX45459.1 - 0.0024 17.7 0.0 0.0073 16.1 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ORX45459.1 - 0.0034 17.9 0.0 0.0065 17.0 0.0 1.6 1 1 0 1 1 1 1 ABC transporter IstB_IS21 PF01695.17 ORX45459.1 - 0.0035 17.1 0.0 0.0088 15.8 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 ORX45459.1 - 0.0049 16.9 0.1 0.017 15.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ORX45459.1 - 0.0051 16.0 0.0 0.0087 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 ORX45459.1 - 0.0051 17.0 0.1 0.037 14.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ORX45459.1 - 0.0065 16.4 0.0 0.027 14.4 0.1 2.1 2 0 0 2 2 2 1 NACHT domain TniB PF05621.11 ORX45459.1 - 0.012 15.1 0.0 0.75 9.2 0.0 3.0 2 1 1 3 3 3 0 Bacterial TniB protein ATPase_2 PF01637.18 ORX45459.1 - 0.012 15.5 0.0 0.038 13.9 0.0 1.7 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ORX45459.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NB-ARC PF00931.22 ORX45459.1 - 0.017 14.3 0.0 5 6.2 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 ORX45459.1 - 0.024 14.6 0.0 0.063 13.2 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ORX45459.1 - 0.027 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 ORX45459.1 - 0.028 14.2 0.0 0.053 13.3 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 ORX45459.1 - 0.029 14.0 2.6 0.29 10.7 0.2 2.6 2 1 1 3 3 3 0 AAA domain Bac_DnaA PF00308.18 ORX45459.1 - 0.035 14.0 0.0 0.057 13.2 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein AAA_28 PF13521.6 ORX45459.1 - 0.048 13.9 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ORX45459.1 - 0.049 13.7 0.0 0.23 11.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) IPT PF01745.16 ORX45459.1 - 0.054 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Isopentenyl transferase AAA_7 PF12775.7 ORX45459.1 - 0.099 12.2 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region SRPRB PF09439.10 ORX45459.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_23 PF13476.6 ORX45459.1 - 0.12 12.9 0.0 0.24 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ORX45459.1 - 0.18 11.1 0.6 0.5 9.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_21 PF13304.6 ORX45459.1 - 0.2 11.4 0.0 0.29 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 ORX45459.1 - 0.2 11.3 0.0 0.33 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain HALZ PF02183.18 ORX45460.1 - 0.017 15.4 0.2 0.017 15.4 0.2 4.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper Meis_PKNOX_N PF16493.5 ORX45460.1 - 0.16 12.3 1.2 12 6.3 0.0 3.4 3 0 0 3 3 3 0 N-terminal of Homeobox Meis and PKNOX1 Fez1 PF06818.15 ORX45460.1 - 0.58 10.6 38.9 2.1 8.7 3.3 3.0 3 0 0 3 3 3 0 Fez1 TMF_TATA_bd PF12325.8 ORX45460.1 - 0.93 9.7 36.8 0.1 12.8 3.9 3.8 1 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding EzrA PF06160.12 ORX45460.1 - 1.1 7.4 29.4 0.03 12.5 20.8 2.4 2 1 0 3 3 3 0 Septation ring formation regulator, EzrA Laminin_II PF06009.12 ORX45460.1 - 2.9 7.9 23.7 1.5 8.9 7.4 2.9 1 1 0 2 2 2 0 Laminin Domain II DUF812 PF05667.11 ORX45460.1 - 3.2 6.5 34.0 5.8 5.7 34.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF745 PF05335.13 ORX45460.1 - 7.7 6.2 32.4 1.8 8.2 12.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Methyltransf_16 PF10294.9 ORX45461.1 - 5.4e-18 65.3 0.0 8.7e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ORX45461.1 - 0.017 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 ORX45461.1 - 0.081 13.6 0.0 2.8 8.7 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain Aldo_ket_red PF00248.21 ORX45462.1 - 1.3e-46 159.1 0.0 4.2e-46 157.5 0.0 1.6 1 1 0 1 1 1 1 Aldo/keto reductase family DUF2293 PF10056.9 ORX45462.1 - 0.16 12.2 0.1 0.33 11.2 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2293) Aldo_ket_red PF00248.21 ORX45463.1 - 2.6e-52 177.8 0.0 3.9e-52 177.3 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family ApbA_C PF08546.11 ORX45464.1 - 2.2e-35 121.6 0.1 2.8e-35 121.2 0.1 1.1 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ORX45464.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA SKA2 PF16740.5 ORX45465.1 - 0.023 14.5 0.1 0.024 14.4 0.1 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Tim17 PF02466.19 ORX45466.1 - 3.1e-09 37.2 5.6 3.9e-09 36.9 5.6 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bromodomain PF00439.25 ORX45467.1 - 1.9e-18 66.3 0.1 6.9e-18 64.5 0.1 2.0 2 0 0 2 2 2 1 Bromodomain Myb_DNA-binding PF00249.31 ORX45467.1 - 0.0093 16.1 0.7 0.018 15.2 0.0 1.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWC7 PF17330.2 ORX45467.1 - 0.038 14.1 1.4 0.13 12.3 0.1 2.4 2 0 0 2 2 2 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 PLDc PF00614.22 ORX45468.1 - 2e-14 53.1 0.4 5.9e-06 26.2 0.0 3.4 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX45468.1 - 6.3e-14 52.0 0.0 1.8e-07 31.1 0.0 2.9 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 ORX45468.1 - 0.00013 21.9 1.3 0.00043 20.2 0.5 2.4 2 1 0 2 2 2 1 PX domain Rap_GAP PF02145.15 ORX45469.1 - 3.6e-54 183.1 0.0 5.8e-54 182.5 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Integrase_H2C2 PF17921.1 ORX45469.1 - 9.1e-08 32.1 2.2 1e-07 31.9 0.6 1.9 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 ORX45469.1 - 0.082 13.1 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger AA_permease PF00324.21 ORX45470.1 - 4.8e-114 381.6 42.2 5.9e-114 381.3 42.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX45470.1 - 2.6e-39 135.3 41.2 3.3e-39 134.9 41.2 1.1 1 0 0 1 1 1 1 Amino acid permease AAA_16 PF13191.6 ORX45471.1 - 7.3e-08 33.0 0.0 4.4e-07 30.4 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX45471.1 - 0.08 13.2 0.0 7 6.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX45471.1 - 0.081 12.7 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein RsgA_GTPase PF03193.16 ORX45471.1 - 0.092 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase TPR_1 PF00515.28 ORX45471.1 - 2 8.4 4.5 18 5.4 0.5 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX45471.1 - 8.7 6.7 10.7 2.4 8.5 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_Crp_2 PF13545.6 ORX45472.1 - 0.04 13.9 0.0 0.069 13.1 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain B-block_TFIIIC PF04182.12 ORX45472.1 - 0.059 13.5 0.2 0.58 10.4 0.0 2.1 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC FG-GAP PF01839.23 ORX45473.1 - 8.1e-14 51.4 20.5 3.6e-07 30.2 5.7 4.5 4 0 0 4 4 4 3 FG-GAP repeat Zn_dep_PLPC PF00882.18 ORX45473.1 - 1.1e-13 51.6 0.5 2e-13 50.7 0.5 1.4 1 0 0 1 1 1 1 Zinc dependent phospholipase C VCBS PF13517.6 ORX45473.1 - 2.4e-06 28.0 13.5 0.0014 19.2 6.9 3.4 2 1 1 3 3 3 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 PF14312.6 ORX45473.1 - 0.0017 18.6 1.6 0.9 9.8 0.0 4.0 3 2 1 4 4 4 1 FG-GAP repeat TcdB_toxin_midN PF12256.8 ORX45473.1 - 0.0019 17.6 0.9 11 5.4 0.0 3.3 2 1 1 3 3 3 3 Insecticide toxin TcdB middle/N-terminal region LGFP PF08310.11 ORX45473.1 - 0.082 13.5 1.6 0.23 12.0 1.6 1.8 1 0 0 1 1 1 0 LGFP repeat zf-C2H2 PF00096.26 ORX45474.1 - 6.2e-09 35.8 7.1 9.1e-05 22.7 1.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX45474.1 - 2.6e-05 24.5 1.3 2.6e-05 24.5 1.3 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX45474.1 - 0.00079 20.1 5.6 0.54 11.2 1.1 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX45474.1 - 0.0025 18.4 1.1 0.098 13.3 0.1 2.5 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 ORX45474.1 - 0.0079 16.5 1.2 0.66 10.3 0.5 2.5 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf_C2H2_ZHX PF18387.1 ORX45474.1 - 0.46 10.2 2.6 0.83 9.3 0.7 2.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Ank_2 PF12796.7 ORX45475.1 - 6.5e-29 100.3 7.8 4.2e-10 40.1 0.0 4.4 2 1 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX45475.1 - 1e-17 62.4 14.2 0.11 13.1 0.1 9.6 9 0 0 9 9 9 6 Ankyrin repeat Ank_4 PF13637.6 ORX45475.1 - 3.3e-16 59.4 11.1 9.5e-05 22.9 0.1 5.6 5 0 0 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX45475.1 - 1e-09 38.4 15.5 0.0021 18.4 0.4 6.8 4 2 5 9 9 9 4 Ankyrin repeats (many copies) Ank PF00023.30 ORX45475.1 - 8.3e-07 29.2 16.9 1.9 9.1 0.7 8.1 7 1 1 8 8 8 2 Ankyrin repeat Antimicrobial19 PF08225.11 ORX45475.1 - 5.7 6.7 5.6 4.4 7.0 2.3 2.2 2 0 0 2 2 2 0 Pseudin antimicrobial peptide Per1 PF04080.13 ORX45476.1 - 4.6e-97 324.8 18.1 5.5e-97 324.5 18.1 1.1 1 0 0 1 1 1 1 Per1-like family ING PF12998.7 ORX45477.1 - 1.6e-08 35.0 2.4 2.2e-08 34.6 0.4 1.9 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX45477.1 - 6e-06 26.1 10.1 1e-05 25.3 10.1 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX45477.1 - 0.03 13.9 4.1 0.064 12.8 4.1 1.6 1 0 0 1 1 1 0 PHD-finger DUF1664 PF07889.12 ORX45477.1 - 0.19 11.8 0.8 0.33 11.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) MTHFR PF02219.17 ORX45478.1 - 2e-114 381.7 0.0 2.4e-114 381.5 0.0 1.0 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PIN_9 PF18477.1 ORX45478.1 - 0.055 13.8 0.0 0.18 12.1 0.0 1.8 2 0 0 2 2 2 0 PIN like domain RIO1 PF01163.22 ORX45479.1 - 4.8e-73 244.8 1.0 4.8e-73 244.8 1.0 1.7 2 0 0 2 2 2 1 RIO1 family CDC45 PF02724.14 ORX45479.1 - 0.00026 19.4 17.0 0.00026 19.4 17.0 1.5 2 0 0 2 2 2 1 CDC45-like protein APH PF01636.23 ORX45479.1 - 0.002 18.1 0.4 0.59 10.0 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family YL1 PF05764.13 ORX45479.1 - 0.11 12.6 39.2 0.028 14.5 28.5 2.5 2 0 0 2 2 2 0 YL1 nuclear protein Fungal_trans PF04082.18 ORX45480.1 - 1.5e-11 43.8 0.7 2.1e-11 43.4 0.7 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain PRIMA1 PF16101.5 ORX45480.1 - 0.013 15.5 8.3 0.54 10.3 0.4 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 ORX45480.1 - 5.4 6.4 5.8 2.1 7.8 0.9 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal RRM_1 PF00076.22 ORX45481.1 - 5.9e-16 58.1 0.1 2.1e-15 56.3 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX45481.1 - 2.1e-08 33.8 0.1 2.5e-08 33.6 0.1 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 ORX45481.1 - 0.007 16.5 0.0 0.0097 16.1 0.0 1.2 1 0 0 1 1 1 1 RRM-like domain RRM_7 PF16367.5 ORX45481.1 - 0.097 12.8 0.2 0.29 11.3 0.2 2.1 1 1 0 1 1 1 0 RNA recognition motif DPBB_1 PF03330.18 ORX45486.1 - 2.2e-08 34.2 0.1 4e-08 33.4 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX45486.1 - 0.00035 20.4 0.3 0.00076 19.3 0.1 1.6 1 1 1 2 2 2 1 Barwin family BPL_C PF02237.17 ORX45486.1 - 0.17 11.8 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Peptidase_M16_C PF05193.21 ORX45487.1 - 8.8e-49 166.0 0.0 1.4e-48 165.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX45487.1 - 7.6e-39 133.1 0.0 2.1e-38 131.6 0.0 1.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) FAM47 PF14642.6 ORX45487.1 - 0.0099 15.5 0.1 0.016 14.8 0.1 1.2 1 0 0 1 1 1 1 FAM47 family ESX-1_EspG PF14011.6 ORX45487.1 - 0.058 13.0 1.2 4 7.0 0.0 2.7 3 0 0 3 3 3 0 EspG family tRNA-synt_2b PF00587.25 ORX45488.1 - 3.5e-35 121.6 0.0 6.2e-35 120.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX45488.1 - 2.6e-18 66.0 0.1 4.7e-18 65.1 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 ORX45488.1 - 2.7e-11 43.4 0.0 6.1e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 ORX45488.1 - 1.2e-10 41.2 0.0 2.6e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 TGS domain tRNA-synt_2b PF00587.25 ORX45489.1 - 6.6e-37 127.2 0.0 1.1e-36 126.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX45489.1 - 6.3e-17 61.5 0.0 1.3e-16 60.5 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain TGS PF02824.21 ORX45489.1 - 4.2e-13 49.1 0.0 1.3e-12 47.6 0.0 1.9 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 ORX45489.1 - 2.5e-12 46.7 0.0 5e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain Glyco_transf_49 PF13896.6 ORX45490.1 - 3e-19 69.6 0.3 7e-19 68.3 0.3 1.5 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan DEAD PF00270.29 ORX45491.1 - 9.9e-21 74.3 0.0 2.2e-20 73.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX45491.1 - 5.5e-20 71.8 0.0 4.5e-18 65.6 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ORX45491.1 - 2e-10 41.2 4.8 2e-10 41.2 4.8 2.2 2 0 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 ORX45491.1 - 4.2e-10 39.4 0.0 1.5e-09 37.6 0.0 1.9 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 ORX45491.1 - 7.5e-07 29.1 0.0 1.6e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 HRDC domain ResIII PF04851.15 ORX45491.1 - 2.5e-06 27.6 0.0 5.2e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_Sgs1 PF11408.8 ORX45491.1 - 0.00044 20.2 0.0 0.00094 19.2 0.0 1.5 1 0 0 1 1 1 1 Sgs1 RecQ helicase TPR_1 PF00515.28 ORX45494.1 - 1.3e-07 31.2 1.9 0.00015 21.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX45494.1 - 2.1e-06 27.7 0.8 7e-06 26.1 0.4 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX45494.1 - 2.4e-05 23.9 1.6 0.0051 16.5 0.1 2.7 2 1 1 3 3 3 2 TPR repeat TPR_2 PF07719.17 ORX45494.1 - 5.9e-05 22.9 2.4 0.04 14.0 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX45494.1 - 0.00022 21.3 0.2 0.035 14.3 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX45494.1 - 0.00033 20.9 0.9 0.017 15.4 0.3 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX45494.1 - 0.00057 19.9 2.6 0.086 13.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX45494.1 - 0.0048 16.3 0.4 0.011 15.1 0.3 1.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_14 PF13428.6 ORX45494.1 - 0.0068 17.1 0.3 1.3 10.0 0.0 3.0 1 1 2 3 3 3 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX45494.1 - 0.0086 15.0 0.1 0.068 12.1 0.0 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 ORX45494.1 - 0.017 15.7 0.2 0.046 14.4 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX45494.1 - 0.064 13.1 3.9 0.24 11.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX45494.1 - 0.077 13.5 1.1 0.16 12.5 0.9 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX45494.1 - 0.14 12.9 1.9 31 5.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2379 PF09543.10 ORX45494.1 - 0.28 11.4 1.8 16 5.7 0.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2379) YojJ PF10372.9 ORX45496.1 - 0.037 14.1 0.2 0.063 13.4 0.2 1.4 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus LPD26 PF18842.1 ORX45496.1 - 0.1 12.5 0.1 0.75 9.8 0.1 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 26 CENP-P PF13096.6 ORX45498.1 - 0.034 13.9 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P Fungal_trans PF04082.18 ORX45499.1 - 1.5e-38 132.4 1.3 2.9e-38 131.4 1.3 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain eIF-3c_N PF05470.12 ORX45500.1 - 1.9e-170 568.1 16.2 1.1e-169 565.6 16.2 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 ORX45500.1 - 1.1e-14 54.8 0.1 5.9e-14 52.5 0.0 2.4 2 0 0 2 2 2 1 PCI domain CTNNBL PF08216.11 ORX45500.1 - 0.65 10.2 4.8 1.7 8.9 3.6 2.4 2 0 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Helicase_C PF00271.31 ORX45504.1 - 2.6e-05 24.5 0.0 3.2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain F-box PF00646.33 ORX45505.1 - 0.017 15.0 0.1 0.026 14.4 0.1 1.3 1 0 0 1 1 1 0 F-box domain PTH2 PF01981.16 ORX45506.1 - 0.018 15.3 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 2_5_RNA_ligase2 PF13563.6 ORX45507.1 - 0.00027 20.9 0.0 0.00039 20.4 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily RabGAP-TBC PF00566.18 ORX45508.1 - 3.1e-44 151.2 0.0 5.2e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cullin_binding PF03556.15 ORX45508.1 - 0.046 14.2 0.4 0.12 12.9 0.4 1.7 1 0 0 1 1 1 0 Cullin binding DUF4864 PF16156.5 ORX45508.1 - 0.16 12.7 0.0 0.37 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4864) SOG2 PF10428.9 ORX45508.1 - 0.27 10.4 12.4 0.35 10.0 12.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein zf-C2H2 PF00096.26 ORX45509.1 - 4.7e-08 33.1 14.1 0.00016 21.9 4.6 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ORX45509.1 - 0.00018 21.7 2.0 0.32 11.3 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX45509.1 - 0.0013 19.3 2.9 1.3 9.8 0.3 2.4 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 ORX45509.1 - 0.048 14.1 4.0 0.048 14.1 4.0 3.9 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX45509.1 - 0.054 14.4 16.0 0.36 11.8 2.9 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX45509.1 - 6 7.0 10.4 4.1 7.5 0.1 3.6 2 1 0 2 2 2 0 C2H2-type zinc finger zf_CCCH_4 PF18345.1 ORX45510.1 - 0.00097 19.1 3.1 0.002 18.1 3.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ORX45510.1 - 0.003 17.4 2.7 0.0066 16.3 2.7 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 ORX45510.1 - 0.0074 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PWI PF01480.17 ORX45510.1 - 0.012 15.9 0.3 0.04 14.2 0.3 1.9 1 0 0 1 1 1 0 PWI domain Porin_O_P PF07396.11 ORX45510.1 - 0.041 13.1 0.0 0.067 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphate-selective porin O and P Autophagy_N PF03986.13 ORX45510.1 - 1.2 9.0 7.2 0.3 11.0 0.4 2.4 2 0 0 2 2 2 0 Autophagocytosis associated protein (Atg3), N-terminal domain SNF2_N PF00176.23 ORX45511.1 - 2.5e-74 250.1 0.7 6.9e-74 248.6 0.7 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 ORX45511.1 - 3.1e-38 130.3 3.9 3.1e-38 130.3 3.9 2.6 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 ORX45511.1 - 8.6e-24 84.4 0.2 8.6e-24 84.4 0.2 3.1 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 ORX45511.1 - 7.2e-19 68.2 0.0 5.5e-18 65.3 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX45511.1 - 8.1e-10 39.0 0.0 8.1e-10 39.0 0.0 2.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ORX45511.1 - 0.0014 18.3 0.0 0.0039 16.9 0.0 1.8 1 1 0 1 1 1 1 SWI2/SNF2 ATPase DEAD PF00270.29 ORX45511.1 - 0.0042 16.9 0.0 0.011 15.6 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-bind_6 PF13921.6 ORX45511.1 - 0.047 14.0 0.7 0.26 11.5 0.7 2.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain AAA_14 PF13173.6 ORX45511.1 - 0.052 13.6 0.0 0.36 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain DBINO PF13892.6 ORX45511.1 - 0.1 12.9 0.0 0.1 12.9 0.0 4.0 5 0 0 5 5 5 0 DNA-binding domain UPF0183 PF03676.14 ORX45512.1 - 1.1e-98 331.1 0.0 7e-98 328.5 0.0 1.9 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0183) IPK PF03770.16 ORX45513.1 - 1.1e-49 169.1 0.0 2.1e-49 168.1 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Adaptin_N PF01602.20 ORX45515.1 - 4.7e-104 348.8 7.6 7.4e-104 348.2 7.6 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatomer_b_Cpla PF14806.6 ORX45515.1 - 5.3e-60 201.0 0.0 1.5e-59 199.6 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Coatamer_beta_C PF07718.12 ORX45515.1 - 2.1e-58 196.2 0.5 4.6e-58 195.1 0.5 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region HEAT_2 PF13646.6 ORX45515.1 - 1.1e-11 44.9 0.1 0.00015 22.1 0.0 5.6 1 1 5 6 6 6 3 HEAT repeats Cnd1 PF12717.7 ORX45515.1 - 1.1e-08 35.3 4.7 1.4e-06 28.5 0.0 3.3 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX45515.1 - 3.1e-06 27.0 2.7 0.018 15.3 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat DUF5578 PF17741.1 ORX45515.1 - 6.2e-06 25.8 3.2 0.00079 18.9 1.3 2.5 2 0 0 2 2 2 2 Family of unknown function (DUF5578) DUF5071 PF16804.5 ORX45515.1 - 0.0021 18.3 1.3 0.037 14.3 0.0 3.0 1 1 2 3 3 3 1 Domain of unknown function (DUF5071) Coatomer_g_Cpla PF16381.5 ORX45515.1 - 0.003 17.7 0.0 0.016 15.3 0.0 2.4 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform DUF2326 PF10088.9 ORX45515.1 - 0.0064 16.2 0.7 0.023 14.4 0.7 1.9 1 0 0 1 1 1 1 Uncharacterised protein conserved in bacteria (DUF2326) HEAT_EZ PF13513.6 ORX45515.1 - 0.019 15.4 0.1 0.44 11.1 0.0 3.3 3 0 0 3 3 3 0 HEAT-like repeat Meis_PKNOX_N PF16493.5 ORX45515.1 - 0.076 13.4 0.5 0.34 11.3 0.5 2.2 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 RabGAP-TBC PF00566.18 ORX45517.1 - 5e-46 157.1 0.0 1e-45 156.1 0.0 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ORX45517.1 - 2.3e-27 95.2 0.8 2.9e-18 65.8 0.3 2.7 2 0 0 2 2 2 2 GRAM domain T4SS_TraI PF16932.5 ORX45517.1 - 0.036 13.3 0.0 0.078 12.1 0.0 1.5 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer Myc_target_1 PF15179.6 ORX45517.1 - 9.4 6.1 7.2 0.34 10.8 0.3 1.9 2 0 0 2 2 2 0 Myc target protein 1 FAD_binding_8 PF08022.12 ORX45519.1 - 0.36 10.9 5.9 7.7 6.6 0.1 4.5 4 1 0 4 4 4 0 FAD-binding domain Dor1 PF04124.12 ORX45520.1 - 1.5e-49 168.5 8.8 1.4e-38 132.5 4.1 2.2 2 0 0 2 2 2 2 Dor1-like family DUF4423 PF14394.6 ORX45520.1 - 0.0055 16.4 0.5 0.11 12.2 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4423) DUF148 PF02520.17 ORX45520.1 - 0.025 14.7 0.3 0.066 13.3 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF148 Spc7_C2 PF15577.6 ORX45520.1 - 0.032 14.3 0.0 0.14 12.3 0.0 2.0 2 0 0 2 2 2 0 Spc7_C2 GAT PF03127.14 ORX45521.1 - 0.019 15.3 0.1 0.028 14.7 0.1 1.3 1 0 0 1 1 1 0 GAT domain VHS PF00790.19 ORX45522.1 - 3.3e-22 78.9 0.8 4.4e-22 78.5 0.8 1.1 1 0 0 1 1 1 1 VHS domain zf_ZIC PF18366.1 ORX45522.1 - 0.039 14.1 0.2 11 6.3 0.1 2.7 2 0 0 2 2 2 0 Zic proteins zinc finger domain GAT PF03127.14 ORX45522.1 - 0.13 12.6 2.3 3.3 8.1 1.1 2.5 2 0 0 2 2 2 0 GAT domain zf-C2H2_jaz PF12171.8 ORX45523.1 - 6.7e-06 26.3 0.9 6.7e-06 26.3 0.9 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX45523.1 - 3.8e-05 23.9 1.5 3.8e-05 23.9 1.5 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ORX45523.1 - 0.018 15.3 8.0 0.023 15.0 0.2 2.9 3 0 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 ORX45523.1 - 0.064 13.4 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2_4 PF13894.6 ORX45523.1 - 0.41 11.6 5.6 1 10.4 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger SF-assemblin PF06705.11 ORX45524.1 - 0.0069 15.8 1.8 2.1 7.6 0.1 2.2 2 0 0 2 2 2 2 SF-assemblin/beta giardin CREPT PF16566.5 ORX45524.1 - 0.022 15.0 6.9 0.41 10.8 0.6 3.0 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Gp58 PF07902.11 ORX45524.1 - 0.26 9.5 1.4 0.47 8.7 1.4 1.3 1 0 0 1 1 1 0 gp58-like protein LMBR1 PF04791.16 ORX45524.1 - 4.9 5.9 5.5 3.6 6.4 3.9 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein IKKbetaNEMObind PF12179.8 ORX45524.1 - 5.7 7.1 8.2 13 5.9 0.9 2.8 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain Rpn3_C PF08375.11 ORX45525.1 - 6.5e-29 100.2 0.5 6.5e-29 100.2 0.5 2.5 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 ORX45525.1 - 3.5e-21 75.7 0.5 1.9e-20 73.4 0.1 2.5 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 ORX45525.1 - 0.15 12.3 3.6 0.14 12.3 1.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX45525.1 - 2.1 8.7 12.7 5.3 7.4 1.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Kelch_1 PF01344.25 ORX45526.1 - 4.8e-45 150.9 3.9 1.8e-08 33.8 0.1 6.1 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ORX45526.1 - 4.6e-42 141.8 5.3 2.9e-09 36.8 0.0 6.1 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX45526.1 - 2.1e-40 136.1 12.0 3.1e-06 27.0 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ORX45526.1 - 4e-36 122.6 6.6 6.1e-06 26.4 0.0 6.2 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX45526.1 - 7.5e-33 111.3 9.5 1.7e-06 27.7 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 ORX45526.1 - 2.6e-31 106.9 12.8 0.00012 22.2 0.1 6.2 4 2 2 6 6 6 6 Kelch motif PQQ_3 PF13570.6 ORX45526.1 - 0.0096 16.4 7.6 6.1 7.5 0.0 5.2 6 1 0 6 6 6 1 PQQ-like domain Asp PF00026.23 ORX45526.1 - 0.11 11.9 0.7 21 4.4 0.0 3.9 4 1 1 5 5 5 0 Eukaryotic aspartyl protease TPALS PF18178.1 ORX45526.1 - 0.27 10.7 0.6 1 8.7 0.0 2.3 3 1 0 3 3 3 0 TIR- and PNP-associating SLOG family S-methyl_trans PF02574.16 ORX45527.1 - 2.4e-65 221.0 0.0 2.7e-65 220.9 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Glyco_tran_WecB PF03808.13 ORX45527.1 - 0.07 13.1 0.0 0.33 10.9 0.0 2.0 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family DUF1636 PF07845.11 ORX45527.1 - 0.12 12.8 0.0 42 4.6 0.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1636) DUF4566 PF15130.6 ORX45527.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) Acetyltransf_1 PF00583.25 ORX45530.1 - 5e-07 30.0 0.1 9.8e-07 29.0 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX45530.1 - 5.9e-05 23.4 0.3 0.00017 21.9 0.3 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX45530.1 - 0.00071 19.5 0.0 0.003 17.5 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 ORX45530.1 - 0.016 15.0 0.0 5.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX45530.1 - 0.031 14.2 0.0 0.35 10.9 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_1 PF00583.25 ORX45531.1 - 1.1e-05 25.7 0.0 2.2e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX45531.1 - 0.00047 20.1 0.0 0.0045 16.9 0.0 2.3 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX45531.1 - 0.0081 16.6 0.2 0.029 14.8 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_18 PF18014.1 ORX45531.1 - 0.011 15.5 0.0 0.65 9.8 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX45531.1 - 0.1 12.6 0.0 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 FR47-like protein adh_short PF00106.25 ORX45532.1 - 3.4e-38 131.1 0.0 4.3e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX45532.1 - 3.8e-23 82.3 0.0 5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX45532.1 - 1e-12 48.4 0.1 3.4e-12 46.6 0.0 1.7 2 0 0 2 2 2 1 KR domain ApbA PF02558.16 ORX45532.1 - 0.009 15.7 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA THF_DHG_CYH_C PF02882.19 ORX45532.1 - 0.014 14.8 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_Gly3P_dh_N PF01210.23 ORX45532.1 - 0.034 14.1 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.6 ORX45532.1 - 0.039 14.4 0.1 0.08 13.4 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Epimerase PF01370.21 ORX45532.1 - 0.044 13.2 0.0 0.078 12.4 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 ORX45532.1 - 0.084 12.8 0.3 0.15 11.9 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3883 PF13020.6 ORX45532.1 - 0.12 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) Cu-oxidase_3 PF07732.15 ORX45533.1 - 3.1e-13 49.8 1.5 6.4e-13 48.8 1.1 1.8 1 1 0 1 1 1 1 Multicopper oxidase Y_phosphatase2 PF03162.13 ORX45536.1 - 4.8e-40 136.8 0.0 5.2e-40 136.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX45536.1 - 2.3e-05 24.2 0.0 2.6e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX45536.1 - 0.0057 16.3 0.0 0.0066 16.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ORX45536.1 - 0.0073 16.3 0.1 0.0075 16.3 0.1 1.2 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF1722 PF08349.11 ORX45537.1 - 0.036 14.3 1.3 0.098 12.9 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Hypoth_Ymh PF09509.10 ORX45537.1 - 0.4 10.6 4.0 0.82 9.6 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (Hypoth_ymh) IPK PF03770.16 ORX45538.1 - 3e-46 157.8 0.0 6.5e-46 156.7 0.0 1.5 1 0 0 1 1 1 1 Inositol polyphosphate kinase Sec10 PF07393.11 ORX45540.1 - 1.7e-187 625.1 1.0 2.2e-187 624.7 1.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 CTD_bind PF04818.13 ORX45540.1 - 0.086 13.7 0.5 2 9.3 0.1 3.2 2 0 0 2 2 2 0 RNA polymerase II-binding domain. Dynactin_p22 PF07426.11 ORX45540.1 - 0.13 12.1 1.4 2.4 8.0 0.1 2.9 2 1 0 2 2 2 0 Dynactin subunit p22 Pkip-1 PF06878.11 ORX45540.1 - 0.49 10.5 3.4 1.1 9.4 1.8 2.3 2 0 0 2 2 2 0 Pkip-1 protein Cas1_AcylT PF07779.12 ORX45543.1 - 2.5e-129 432.3 26.5 4e-129 431.6 26.5 1.2 1 0 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p Pullulanase_Ins PF18494.1 ORX45544.1 - 0.0079 16.6 0.2 0.011 16.2 0.2 1.2 1 0 0 1 1 1 1 Pullulanase Ins domain Peptidase_S13 PF02113.15 ORX45544.1 - 0.072 11.8 0.0 0.077 11.7 0.0 1.0 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family RAP1 PF07218.11 ORX45545.1 - 0.13 10.5 0.1 0.15 10.3 0.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pkinase PF00069.25 ORX45546.1 - 2.8e-61 207.2 0.0 3.3e-61 207.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45546.1 - 2.2e-19 69.7 0.0 6.7e-19 68.2 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX45546.1 - 2.4e-06 27.7 0.5 8.6e-06 25.8 0.4 1.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX45546.1 - 0.013 14.2 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 ORX45546.1 - 0.021 14.4 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX45546.1 - 0.078 12.3 1.4 0.14 11.5 1.4 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family GCV_T PF01571.21 ORX45548.1 - 8.7e-88 294.0 0.0 1.1e-87 293.7 0.0 1.1 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ORX45548.1 - 1.5e-22 79.3 0.0 3e-22 78.3 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain SoxG PF04268.12 ORX45548.1 - 0.00021 21.4 0.0 0.42 10.8 0.0 2.4 1 1 1 2 2 2 2 Sarcosine oxidase, gamma subunit family DUF3659 PF12396.8 ORX45548.1 - 0.011 15.6 0.2 0.039 13.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3659) OrsD PF12013.8 ORX45550.1 - 4.5e-08 33.5 1.3 4.5e-08 33.5 1.3 1.8 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 ORX45550.1 - 0.027 14.1 0.3 0.027 14.1 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger C2H2-type GDH_N PF12466.8 ORX45550.1 - 0.11 12.7 0.1 0.39 10.9 0.0 1.8 2 0 0 2 2 2 0 Glutamate dehydrogenase N terminal DUF1547 PF07577.11 ORX45550.1 - 0.23 11.8 0.6 25 5.3 0.0 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1547) zf-C2H2_4 PF13894.6 ORX45550.1 - 4.9 8.3 7.2 51 5.1 0.0 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger DUF1266 PF06889.11 ORX45647.1 - 0.0073 16.4 0.7 0.012 15.6 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1266) SprA-related PF12118.8 ORX45647.1 - 0.039 13.1 1.5 0.057 12.6 1.5 1.2 1 0 0 1 1 1 0 SprA-related family TMPIT PF07851.13 ORX45647.1 - 0.14 11.4 0.4 0.22 10.7 0.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein CotH PF08757.11 ORX45648.1 - 3.2e-41 141.9 3.2 4.2e-41 141.5 3.2 1.1 1 0 0 1 1 1 1 CotH kinase protein Phi_1 PF04674.12 ORX45649.1 - 3.6e-20 72.4 0.8 4.6e-20 72.1 0.8 1.1 1 0 0 1 1 1 1 Phosphate-induced protein 1 conserved region LRR_9 PF14580.6 ORX45651.1 - 2.3e-62 209.6 4.7 2.6e-62 209.4 4.7 1.0 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ORX45651.1 - 1.6e-07 31.5 10.2 0.00059 20.2 0.6 3.2 2 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX45651.1 - 1.9e-07 30.7 4.9 5.4e-07 29.3 3.3 2.5 3 0 0 3 3 3 1 Leucine rich repeat Desmo_N PF06771.11 ORX45651.1 - 0.26 11.7 1.3 42 4.6 0.0 2.8 1 1 1 3 3 3 0 Viral Desmoplakin N-terminus Kinesin_assoc PF16183.5 ORX45652.1 - 0.17 12.0 1.1 0.39 10.9 1.1 1.5 1 0 0 1 1 1 0 Kinesin-associated Carboxyl_trans PF01039.22 ORX45653.1 - 1.9e-77 261.0 0.0 2.2e-77 260.8 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain RRM_1 PF00076.22 ORX45654.1 - 6.8e-26 89.9 0.0 4.8e-14 51.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX45654.1 - 0.032 14.3 0.0 0.21 11.7 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif ACOX PF01756.19 ORX45655.1 - 6.2e-34 117.1 0.0 1.5e-33 115.9 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ORX45655.1 - 1.6e-13 50.7 0.1 3e-13 49.8 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ORX45655.1 - 3.1e-12 47.1 0.3 5.8e-12 46.3 0.3 1.5 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Spidroin_N PF16763.5 ORX45655.1 - 0.0065 16.5 0.0 0.041 13.9 0.0 2.3 3 0 0 3 3 3 1 Major ampullate spidroin 1, spider silk protein 1, N-term PseudoU_synth_2 PF00849.22 ORX45656.1 - 1.5e-30 106.4 0.0 2.3e-30 105.8 0.0 1.3 1 0 0 1 1 1 1 RNA pseudouridylate synthase S4 PF01479.25 ORX45656.1 - 0.054 13.2 0.2 0.14 11.9 0.2 1.7 1 0 0 1 1 1 0 S4 domain HECT PF00632.25 ORX45657.1 - 2.6e-85 286.6 0.0 4.7e-85 285.8 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Velvet PF11754.8 ORX45658.1 - 3e-29 102.7 0.1 3.3e-29 102.6 0.1 1.0 1 0 0 1 1 1 1 Velvet factor MMR_HSR1 PF01926.23 ORX45659.1 - 6e-21 74.7 0.1 1.8e-20 73.1 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX45659.1 - 4.1e-08 33.5 0.5 0.012 15.7 0.1 2.9 2 1 1 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ORX45659.1 - 4.4e-08 33.2 0.1 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX45659.1 - 3.2e-06 26.7 0.0 4.7e-06 26.2 0.0 1.4 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ORX45659.1 - 0.00074 19.0 0.1 0.0019 17.7 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ORX45659.1 - 0.0009 18.8 4.0 0.01 15.4 0.5 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Septin PF00735.18 ORX45659.1 - 0.00098 18.5 4.9 0.026 13.8 0.6 2.9 2 1 0 2 2 2 1 Septin Roc PF08477.13 ORX45659.1 - 0.0093 16.2 0.1 0.084 13.1 0.1 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ORX45659.1 - 0.036 14.3 1.6 0.17 12.2 0.1 2.6 3 1 0 3 3 3 0 AAA domain ABC_tran PF00005.27 ORX45659.1 - 0.087 13.3 0.0 0.3 11.6 0.0 1.9 2 0 0 2 2 2 0 ABC transporter MnmE_helical PF12631.7 ORX45660.1 - 1.5e-50 172.3 1.6 1.8e-50 172.0 1.6 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 ORX45660.1 - 2.1e-37 127.9 0.0 6e-37 126.5 0.0 1.8 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 ORX45660.1 - 2.9e-20 72.5 0.0 6.9e-20 71.2 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX45660.1 - 7.1e-07 28.9 0.0 3.1e-06 26.8 0.0 2.1 1 1 1 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX45660.1 - 5.2e-06 26.6 0.0 1e-05 25.7 0.0 1.6 1 0 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 ORX45660.1 - 0.002 18.1 0.1 0.31 10.9 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX45660.1 - 0.0043 16.6 0.3 1.9 8.0 0.1 2.8 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain AAA_28 PF13521.6 ORX45660.1 - 0.018 15.3 0.0 0.036 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX45660.1 - 0.023 15.3 0.0 0.071 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 ORX45660.1 - 0.023 13.5 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_22 PF13401.6 ORX45660.1 - 0.024 14.9 0.0 0.77 10.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX45660.1 - 0.052 13.3 0.0 0.099 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 ORX45660.1 - 0.11 12.0 0.1 4.7 6.6 0.0 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family ABC_tran PF00005.27 ORX45660.1 - 0.13 12.8 0.0 0.25 11.8 0.0 1.6 1 0 0 1 1 1 0 ABC transporter JAB PF01398.21 ORX45661.1 - 1.3e-16 60.7 0.0 2.5e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 ORX45661.1 - 1.5e-16 60.6 3.3 2.7e-16 59.8 3.3 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 ORX45661.1 - 2.6e-05 24.0 0.0 7.6e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Kinesin PF00225.23 ORX45662.1 - 7.9e-105 350.4 0.0 1.1e-102 343.4 0.0 2.7 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX45662.1 - 1.5e-19 70.4 0.0 2.6e-14 53.4 0.0 3.0 2 0 0 2 2 2 2 Microtubule binding bacHORMA_1 PF18138.1 ORX45662.1 - 0.014 15.3 0.8 0.16 11.8 1.5 2.5 1 1 1 2 2 2 0 Bacterial HORMA domain family 1 TolA_bind_tri PF16331.5 ORX45662.1 - 0.014 15.4 2.8 0.014 15.4 2.8 5.8 6 0 0 6 6 6 0 TolA binding protein trimerisation YebG PF07130.12 ORX45662.1 - 0.025 14.4 0.9 0.082 12.8 0.9 1.9 1 0 0 1 1 1 0 YebG protein DUF3867 PF12983.7 ORX45662.1 - 0.049 13.7 0.3 0.049 13.7 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3867) PKcGMP_CC PF16808.5 ORX45662.1 - 1.9 8.4 15.8 3 7.8 0.0 4.8 4 1 1 5 5 5 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MRFAP1 PF15155.6 ORX45662.1 - 4.5 7.8 10.8 0.071 13.6 1.1 3.0 3 1 1 4 4 4 0 MORF4 family-associated protein1 60KD_IMP PF02096.20 ORX45662.1 - 9 6.2 12.4 7.3 6.5 0.1 4.2 4 0 0 4 4 4 0 60Kd inner membrane protein SET PF00856.28 ORX45663.1 - 4.4e-19 69.5 1.2 9.7e-19 68.4 0.2 2.1 2 1 0 2 2 2 1 SET domain Pre-SET PF05033.16 ORX45663.1 - 9.6e-16 58.4 5.7 9.6e-16 58.4 5.7 2.1 2 0 0 2 2 2 1 Pre-SET motif Chromo PF00385.24 ORX45663.1 - 3.4e-08 33.3 0.1 6.2e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Yip1 PF04893.17 ORX45664.1 - 2e-19 69.9 14.3 3.6e-19 69.1 14.3 1.4 1 1 0 1 1 1 1 Yip1 domain NAD_binding_7 PF13241.6 ORX45666.1 - 6.6e-29 100.4 0.0 9.7e-29 99.9 0.0 1.2 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 ORX45666.1 - 1.7e-12 46.6 0.2 3.1e-12 45.7 0.2 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 ORX45666.1 - 4.2e-11 42.3 0.1 9.5e-11 41.2 0.1 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal AlaDh_PNT_C PF01262.21 ORX45666.1 - 0.0051 16.1 0.1 0.0078 15.5 0.1 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 ORX45666.1 - 0.041 13.2 0.7 0.46 9.8 0.0 2.3 3 0 0 3 3 3 0 ThiF family Pyr_redox_2 PF07992.14 ORX45666.1 - 0.073 12.3 0.1 0.098 11.9 0.1 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX45666.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX45666.1 - 0.13 12.8 0.4 0.28 11.8 0.4 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CH PF00307.31 ORX45667.1 - 5.8e-31 106.9 0.2 9.9e-14 51.4 0.1 4.0 3 0 0 3 3 3 2 Calponin homology (CH) domain GAS2 PF02187.17 ORX45667.1 - 1.3e-11 44.4 0.3 3.9e-11 42.9 0.3 1.9 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain CAMSAP_CH PF11971.8 ORX45667.1 - 0.00014 21.6 0.0 0.00076 19.3 0.0 2.4 1 0 0 1 1 1 1 CAMSAP CH domain BORCS8 PF10167.9 ORX45667.1 - 6.4 6.8 7.8 2.1 8.3 0.4 4.2 3 0 0 3 3 3 0 BLOC-1-related complex sub-unit 8 PHD PF00628.29 ORX45668.1 - 1.2e-07 31.5 11.7 1.7e-07 31.0 9.0 2.3 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 ORX45668.1 - 0.00039 19.9 3.9 0.00039 19.9 3.9 1.9 2 0 0 2 2 2 1 PHD-finger PHD_3 PF13922.6 ORX45668.1 - 0.025 15.0 1.2 0.09 13.2 1.2 1.9 1 0 0 1 1 1 0 PHD domain of transcriptional enhancer, Asx PHF5 PF03660.14 ORX45668.1 - 0.13 12.5 4.1 1.8 8.8 1.0 2.3 2 0 0 2 2 2 0 PHF5-like protein Sgf11 PF08209.11 ORX45668.1 - 3.6 7.2 8.0 0.39 10.3 0.8 2.9 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) C1_1 PF00130.22 ORX45668.1 - 8.9 6.3 7.8 3 7.8 3.2 2.3 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) LAG1-DNAbind PF09271.11 ORX45669.1 - 4.8e-45 153.9 0.4 1.1e-44 152.7 0.4 1.7 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ORX45669.1 - 4.8e-24 85.3 0.2 4.1e-22 79.1 0.2 3.2 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain ARPC4 PF05856.12 ORX45670.1 - 2.4e-79 264.8 6.2 2.6e-79 264.6 6.2 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Sm_like PF16243.5 ORX45670.1 - 0.03 14.5 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 Sm_like domain NUC153 PF08159.12 ORX45671.1 - 7.8e-10 38.4 1.3 1.6e-09 37.4 1.3 1.6 1 0 0 1 1 1 1 NUC153 domain ANAPC4_WD40 PF12894.7 ORX45671.1 - 0.00029 21.1 0.0 0.075 13.3 0.0 3.3 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX45671.1 - 0.0065 17.3 0.1 34 5.5 0.0 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat NOA36 PF06524.12 ORX45671.1 - 1.8 7.8 8.9 3.7 6.8 8.9 1.5 1 0 0 1 1 1 0 NOA36 protein AhpC-TSA PF00578.21 ORX45672.1 - 3.6e-12 46.3 0.0 4.5e-12 46.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX45672.1 - 3e-05 23.8 0.0 3.6e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin PDDEXK_2 PF12784.7 ORX45673.1 - 0.03 13.9 0.0 0.051 13.1 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease family transposase C12orf66_like PF09404.10 ORX45674.1 - 3.4e-43 148.1 0.2 5.2e-43 147.5 0.2 1.2 1 0 0 1 1 1 1 KICSTOR complex C12orf66 like Sen15 PF09631.10 ORX45675.1 - 8.2e-22 77.4 0.2 1e-21 77.1 0.2 1.1 1 0 0 1 1 1 1 Sen15 protein Sel1 PF08238.12 ORX45677.1 - 2.9e-126 409.0 52.5 1.9e-11 44.2 0.0 14.7 15 0 0 15 15 15 14 Sel1 repeat Flu_M1_C PF08289.11 ORX45677.1 - 0.00078 19.6 0.0 8.8 6.6 0.0 4.6 4 1 1 5 5 5 1 Influenza Matrix protein (M1) C-terminal domain RNR_Alpha PF17975.1 ORX45677.1 - 0.018 15.5 0.2 0.038 14.5 0.2 1.6 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain TPR_16 PF13432.6 ORX45677.1 - 0.022 15.4 17.3 6.2 7.6 0.0 6.8 7 1 1 8 8 8 0 Tetratricopeptide repeat Fib_succ_major PF09603.10 ORX45677.1 - 0.83 10.3 13.9 19 5.8 0.4 5.2 1 1 3 4 4 4 0 Fibrobacter succinogenes major domain (Fib_succ_major) pP_pnuc_1 PF18165.1 ORX45677.1 - 1.6 8.6 3.1 1.2e+02 2.6 0.0 4.1 2 1 4 6 6 6 0 Predicted pPIWI-associating nuclease DUF5401 PF17380.2 ORX45678.1 - 0.0033 15.6 1.0 0.0033 15.6 1.0 1.3 1 1 0 1 1 1 1 Family of unknown function (DUF5401) polyprenyl_synt PF00348.17 ORX45679.1 - 5e-66 222.4 0.0 6.1e-66 222.1 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CPSase_L_D2 PF02786.17 ORX45680.1 - 3.5e-76 255.4 0.1 6.2e-76 254.6 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ORX45680.1 - 2.1e-46 157.0 0.2 5.5e-46 155.6 0.2 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX45680.1 - 2.7e-35 120.7 0.0 5.8e-35 119.7 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ORX45680.1 - 8.7e-17 60.7 2.5 2.1e-16 59.5 2.5 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX45680.1 - 6.6e-10 38.9 0.2 1.6e-09 37.6 0.2 1.6 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX45680.1 - 1.6e-05 24.5 0.5 3.9e-05 23.3 0.5 1.7 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ORX45680.1 - 0.0004 20.5 0.1 0.00077 19.5 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ORX45680.1 - 0.00098 18.9 0.1 0.0018 18.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Biotin_lipoyl_2 PF13533.6 ORX45680.1 - 0.0015 18.3 0.1 0.55 10.1 0.0 2.9 2 1 1 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 ORX45680.1 - 0.0019 18.9 0.3 0.51 11.1 0.0 3.3 3 0 0 3 3 3 1 HlyD family secretion protein ATPgrasp_ST PF14397.6 ORX45680.1 - 0.0061 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp ATPgrasp_N PF18130.1 ORX45680.1 - 0.089 13.4 0.4 7.4 7.2 0.0 3.3 3 0 0 3 3 3 0 ATP-grasp N-terminal domain TMA7 PF09072.10 ORX45681.1 - 1.5e-27 96.2 21.5 1.7e-27 96.0 21.5 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Aa_trans PF01490.18 ORX45683.1 - 6.4e-57 193.1 30.2 7.3e-57 192.9 30.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ERGIC_N PF13850.6 ORX45683.1 - 1 9.8 3.5 48 4.4 0.1 3.5 2 1 1 3 3 3 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) GN3L_Grn1 PF08701.11 ORX45685.1 - 6.1e-23 80.7 22.7 6.1e-23 80.7 22.7 1.9 1 1 1 2 2 2 1 GNL3L/Grn1 putative GTPase DEAD PF00270.29 ORX45686.1 - 9.3e-45 152.5 0.2 1.9e-44 151.6 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX45686.1 - 1.4e-28 99.4 2.3 1.1e-26 93.4 0.3 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX45686.1 - 9.2e-05 22.5 1.5 0.00012 22.1 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ORX45686.1 - 0.053 12.9 0.1 0.053 12.9 0.1 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit API5 PF05918.11 ORX45686.1 - 0.076 11.8 6.9 0.12 11.2 6.9 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) UvrD-helicase PF00580.21 ORX45686.1 - 0.18 11.3 0.1 0.18 11.3 0.1 2.2 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain GRP PF07172.11 ORX45686.1 - 0.42 11.3 9.9 0.78 10.5 9.9 1.4 1 0 0 1 1 1 0 Glycine rich protein family TFIIA PF03153.13 ORX45686.1 - 2.3 8.1 17.7 3.4 7.6 17.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SBF_like PF13593.6 ORX45687.1 - 1.6e-79 267.4 15.9 1.9e-79 267.3 15.9 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Adeno_E3_CR2 PF02439.15 ORX45688.1 - 0.01 15.6 0.1 0.02 14.6 0.1 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Romo1 PF10247.9 ORX45688.1 - 0.056 13.8 0.2 0.12 12.8 0.2 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 DUF3948 PF13134.6 ORX45688.1 - 0.33 10.7 2.2 0.94 9.2 2.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3948) Podoplanin PF05808.11 ORX45688.1 - 8.2 6.5 7.7 1.6 8.8 0.1 2.5 2 1 0 2 2 2 0 Podoplanin Sel1 PF08238.12 ORX45689.1 - 5.1e-17 61.9 12.5 0.0017 19.0 0.2 6.1 6 0 0 6 6 6 4 Sel1 repeat CS PF04969.16 ORX45689.1 - 9.6e-10 39.3 0.0 2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 CS domain TPR_1 PF00515.28 ORX45689.1 - 0.00057 19.6 3.6 1.5 8.8 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX45689.1 - 0.0038 17.5 2.9 0.57 10.5 0.2 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX45689.1 - 0.0062 16.6 7.8 2.2 8.6 0.3 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX45689.1 - 0.0075 16.2 1.1 0.15 12.2 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX45689.1 - 0.017 15.3 1.5 52 4.4 0.1 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 ORX45689.1 - 0.031 14.4 9.9 1.5 9.0 0.0 4.0 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain DUF5077 PF16871.5 ORX45689.1 - 0.12 12.3 0.0 15 5.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5077) Kelch_5 PF13854.6 ORX45690.1 - 0.0026 17.7 2.4 0.037 14.0 0.0 3.1 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ORX45690.1 - 0.017 15.1 0.5 4.5 7.4 0.2 2.5 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX45690.1 - 0.022 14.7 0.3 0.42 10.7 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ORX45691.1 - 3.3e-12 46.2 5.7 5.1e-06 26.4 0.1 4.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX45691.1 - 1.2e-09 37.9 0.3 0.12 12.5 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ORX45691.1 - 2.1e-05 24.3 2.1 0.09 12.8 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ORX45691.1 - 0.00024 21.3 8.9 0.26 11.6 0.0 4.9 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ORX45691.1 - 0.04 14.2 0.0 0.04 14.2 0.0 5.1 5 1 0 5 5 5 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX45691.1 - 0.13 11.9 4.1 23 4.7 0.0 4.1 3 1 0 3 3 3 0 Kelch motif VSP PF03302.13 ORX45691.1 - 1.4 7.7 3.3 2.6 6.8 3.3 1.4 1 0 0 1 1 1 0 Giardia variant-specific surface protein SNF2_N PF00176.23 ORX45692.1 - 5.1e-62 209.6 0.2 1.1e-61 208.5 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX45692.1 - 2.3e-18 66.6 0.0 1.6e-17 63.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX45692.1 - 1.4e-08 34.9 0.0 3.3e-08 33.7 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HSA PF07529.13 ORX45692.1 - 3e-07 30.7 2.2 3e-07 30.7 2.2 3.0 2 0 0 2 2 2 1 HSA DEAD_2 PF06733.15 ORX45692.1 - 0.063 12.9 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 DEAD_2 HLH PF00010.26 ORX45693.1 - 1.2e-11 44.4 0.9 1.2e-11 44.4 0.9 2.1 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SPT16 PF08644.11 ORX45693.1 - 0.02 15.1 0.8 0.034 14.3 0.8 1.4 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DUF4482 PF14818.6 ORX45693.1 - 0.63 10.9 7.7 0.45 11.4 5.6 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4482) Kelch_4 PF13418.6 ORX45696.1 - 3.5e-18 65.3 7.1 7.5e-08 32.3 0.0 5.2 5 1 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX45696.1 - 5.9e-17 61.2 1.5 1.5e-07 31.3 0.2 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ORX45696.1 - 8.6e-14 50.9 0.3 3.1e-05 23.8 0.2 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ORX45696.1 - 4.3e-13 49.0 8.9 1.7e-07 31.3 0.4 4.6 5 0 0 5 5 4 2 Kelch motif Kelch_3 PF13415.6 ORX45696.1 - 4.4e-12 46.0 16.7 4.7e-08 33.1 0.1 5.0 4 2 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX45696.1 - 1.7e-11 43.5 5.8 1.1e-07 31.3 0.3 4.1 4 0 0 4 4 4 2 Kelch motif Podoplanin PF05808.11 ORX45696.1 - 0.00097 19.3 0.1 0.0019 18.3 0.1 1.5 1 0 0 1 1 1 1 Podoplanin SKG6 PF08693.10 ORX45696.1 - 0.01 15.2 0.5 0.021 14.2 0.5 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Amnionless PF14828.6 ORX45696.1 - 0.02 13.7 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Amnionless RAG2 PF03089.14 ORX45696.1 - 0.074 12.0 0.1 0.43 9.5 0.0 2.2 2 1 1 3 3 3 0 Recombination activating protein 2 DUF3042 PF11240.8 ORX45696.1 - 2 8.5 3.5 4.5 7.4 3.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Bacteriocin_IIc PF10439.9 ORX45696.1 - 7 6.8 9.6 0.9 9.7 3.1 2.7 3 0 0 3 3 3 0 Bacteriocin class II with double-glycine leader peptide Rrn6 PF10214.9 ORX45697.1 - 0.0015 17.1 1.0 0.0046 15.5 0.1 1.9 2 0 0 2 2 2 2 RNA polymerase I-specific transcription-initiation factor Alpha_kinase PF02816.18 ORX45698.1 - 0.14 12.2 0.1 0.22 11.6 0.1 1.2 1 0 0 1 1 1 0 Alpha-kinase family FUR PF01475.19 ORX45699.1 - 0.13 12.4 0.0 0.43 10.7 0.0 1.8 1 0 0 1 1 1 0 Ferric uptake regulator family HATPase_c PF02518.26 ORX45701.1 - 2.3e-28 98.9 0.0 1.1e-26 93.5 0.0 2.8 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX45701.1 - 2.4e-23 82.4 1.7 2.4e-23 82.4 1.7 2.7 3 1 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 ORX45701.1 - 1.2e-13 50.9 1.4 3.9e-13 49.2 1.4 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain YbaB_DNA_bd PF02575.16 ORX45701.1 - 0.078 13.2 0.0 0.078 13.2 0.0 2.7 3 0 0 3 3 3 0 YbaB/EbfC DNA-binding family YhfH PF14149.6 ORX45703.1 - 0.018 15.0 0.5 0.046 13.7 0.5 1.7 1 0 0 1 1 1 0 YhfH-like protein Filament PF00038.21 ORX45703.1 - 0.018 14.6 31.4 0.011 15.3 8.5 3.1 2 1 1 3 3 3 0 Intermediate filament protein Phasin PF05597.11 ORX45703.1 - 2.4 8.1 12.8 0.58 10.2 1.8 2.6 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3584 PF12128.8 ORX45703.1 - 2.6 5.5 34.6 0.09 10.3 14.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) FAM184 PF15665.5 ORX45703.1 - 8.1 6.2 40.7 2.3 7.9 16.0 2.7 2 1 0 2 2 2 0 Family with sequence similarity 184, A and B MFAP1 PF06991.11 ORX45704.1 - 7.6e-71 238.4 29.0 7.6e-71 238.4 29.0 3.2 2 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing BES1_N PF05687.13 ORX45706.1 - 8.3 6.8 11.4 2.8 8.3 3.0 2.6 2 0 0 2 2 2 0 BES1/BZR1 plant transcription factor, N-terminal OrfB_Zn_ribbon PF07282.11 ORX45707.1 - 8.6e-10 38.4 2.5 1.6e-09 37.5 2.5 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX45707.1 - 0.078 12.6 0.8 0.14 11.8 0.8 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal DUF4503 PF14951.6 ORX45707.1 - 0.42 9.0 2.4 0.72 8.2 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) Complex1_LYR PF05347.15 ORX45708.1 - 5.5e-13 48.8 2.0 6.5e-13 48.5 2.0 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX45708.1 - 2.7e-05 24.8 0.8 3.5e-05 24.5 0.8 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 ORX45708.1 - 0.017 15.7 0.5 0.03 14.9 0.5 1.4 1 1 0 1 1 1 0 Complex1_LYR-like CX9C PF16860.5 ORX45709.1 - 3.8e-15 55.6 11.4 3e-08 33.5 2.5 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ORX45709.1 - 1.9e-05 24.6 3.2 0.016 15.3 0.1 3.5 2 1 1 3 3 3 3 CHCH domain Pet191_N PF10203.9 ORX45709.1 - 0.0011 19.3 8.4 0.039 14.3 1.3 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase assembly protein PET191 TPR_17 PF13431.6 ORX45709.1 - 0.004 17.4 3.3 0.033 14.6 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat MTCP1 PF08991.10 ORX45709.1 - 0.0058 16.8 2.7 0.0058 16.8 2.7 2.6 1 1 2 3 3 3 1 Mature-T-Cell Proliferation I type TPR_6 PF13174.6 ORX45709.1 - 0.026 15.1 0.5 3.1 8.6 0.0 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX45709.1 - 0.052 13.4 2.3 13 5.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat UCR_hinge PF02320.16 ORX45709.1 - 0.054 13.7 6.5 0.26 11.5 1.1 2.5 1 1 1 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein GCK PF07802.11 ORX45709.1 - 0.12 12.8 5.6 0.22 12.0 0.6 2.3 1 1 1 2 2 2 0 GCK domain Fer4_21 PF14697.6 ORX45709.1 - 0.14 12.3 4.6 2 8.6 0.2 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Cmc1 PF08583.10 ORX45709.1 - 0.54 10.3 11.9 2.1 8.4 3.5 2.6 1 1 0 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 ORX45709.1 - 3.9 7.9 8.8 0.41 11.0 1.6 2.7 2 1 1 3 3 3 0 Cytochrome C oxidase copper chaperone (COX17) DUF3242 PF11586.8 ORX45710.1 - 0.059 13.1 0.1 0.14 11.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3242) HlyIII PF03006.20 ORX45711.1 - 4.1e-54 183.7 32.0 5e-54 183.4 32.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related PAF-AH_p_II PF03403.13 ORX45711.1 - 0.019 13.5 0.3 0.21 10.1 0.0 2.0 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II PRCC PF10253.9 ORX45712.1 - 2.9e-05 25.0 1.5 3.8e-05 24.6 1.5 1.1 1 0 0 1 1 1 1 Mitotic checkpoint regulator, MAD2B-interacting PepSY_TM PF03929.16 ORX45712.1 - 0.013 15.2 0.0 0.018 14.7 0.0 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Mid2 PF04478.12 ORX45712.1 - 0.016 15.0 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF2076 PF09849.9 ORX45712.1 - 0.072 13.1 5.4 0.16 12.0 4.9 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Nitrate_red_gam PF02665.14 ORX45712.1 - 0.1 12.1 0.0 0.15 11.6 0.0 1.2 1 0 0 1 1 1 0 Nitrate reductase gamma subunit Yip1 PF04893.17 ORX45712.1 - 0.11 12.2 0.0 0.48 10.1 0.0 1.8 2 0 0 2 2 2 0 Yip1 domain CD34_antigen PF06365.12 ORX45712.1 - 0.17 11.4 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family Ndc1_Nup PF09531.10 ORX45712.1 - 3.6 6.2 6.9 4.2 5.9 6.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pkinase_Tyr PF07714.17 ORX45714.1 - 2.1e-24 86.2 0.0 2.9e-24 85.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ORX45714.1 - 1.9e-23 83.2 0.0 3e-23 82.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ORX45714.1 - 0.24 10.7 0.7 0.43 9.9 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DEAD PF00270.29 ORX45715.1 - 1.4e-45 155.2 0.0 3.2e-45 154.1 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX45715.1 - 2.2e-30 105.2 0.0 5.6e-30 103.9 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RanBP PF00641.18 ORX45715.1 - 6.7e-19 66.9 12.0 8.4e-11 41.0 3.4 2.5 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others ResIII PF04851.15 ORX45715.1 - 0.0016 18.4 0.0 0.0036 17.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ORX45715.1 - 0.1 11.3 0.0 1.3 7.7 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DZR PF12773.7 ORX45715.1 - 0.15 12.1 8.0 0.43 10.6 8.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon DUF35_N PF12172.8 ORX45715.1 - 0.48 10.4 15.8 2.5 8.1 3.5 2.5 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF957 PF06117.11 ORX45715.1 - 5.6 6.6 4.9 3.4 7.3 1.6 2.2 2 0 0 2 2 2 0 Enterobacterial protein of unknown function (DUF957) Itfg2 PF15907.5 ORX45716.1 - 0.072 12.1 0.1 1.2 8.1 0.0 2.2 1 1 1 2 2 2 0 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_Mid PF14783.6 ORX45716.1 - 0.13 12.3 0.0 4.5 7.4 0.0 3.1 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region HMG_box PF00505.19 ORX45717.1 - 1.7e-18 66.8 0.4 1.7e-18 66.8 0.4 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX45717.1 - 2.9e-12 47.0 0.3 2.9e-12 47.0 0.3 1.9 2 0 0 2 2 2 1 HMG-box domain Zeta_toxin PF06414.12 ORX45717.1 - 0.067 12.5 1.3 0.36 10.1 0.1 2.4 2 1 1 3 3 3 0 Zeta toxin TPR_MLP1_2 PF07926.12 ORX45717.1 - 0.12 12.5 4.2 0.59 10.2 0.1 2.5 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein HlyE PF06109.13 ORX45717.1 - 0.15 11.3 0.1 0.3 10.3 0.1 1.4 1 0 0 1 1 1 0 Haemolysin E (HlyE) CCDC106 PF15794.5 ORX45717.1 - 0.8 9.4 8.5 0.37 10.5 5.2 2.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 106 DHR10 PF18595.1 ORX45717.1 - 2.3 8.3 8.0 0.52 10.4 2.5 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain NEMO PF11577.8 ORX45717.1 - 3.4 7.7 7.6 4 7.5 1.1 2.5 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO ZapB PF06005.12 ORX45717.1 - 4.2 7.9 9.4 0.25 11.8 1.5 2.2 2 1 0 2 2 2 0 Cell division protein ZapB N_BRCA1_IG PF16158.5 ORX45718.1 - 2.2e-30 105.4 0.0 9.7e-30 103.3 0.0 2.2 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 ORX45718.1 - 4e-15 55.4 24.4 1.4e-10 40.8 7.3 2.5 2 0 0 2 2 2 2 Zinc finger, ZZ type PB1 PF00564.24 ORX45718.1 - 1.5e-05 24.9 0.2 3.9e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 PB1 domain C1_2 PF03107.16 ORX45718.1 - 0.014 15.6 7.3 0.014 15.6 7.3 2.6 2 0 0 2 2 2 0 C1 domain CTXphi_pIII-N1 PF16710.5 ORX45718.1 - 0.018 15.1 0.0 0.06 13.5 0.0 1.9 1 0 0 1 1 1 0 N-terminal N1 domain of Vibrio phage CTXphi pIII TrkH PF02386.16 ORX45719.1 - 3e-95 319.6 2.3 3.8e-95 319.2 2.3 1.0 1 0 0 1 1 1 1 Cation transport protein RIC3 PF15361.6 ORX45719.1 - 0.012 16.1 0.0 0.11 12.9 0.0 2.1 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DKCLD PF08068.12 ORX45720.1 - 5e-34 116.2 0.3 1.4e-32 111.5 0.3 2.6 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 ORX45720.1 - 2.5e-23 82.0 0.3 4.8e-23 81.1 0.3 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 ORX45720.1 - 3e-23 82.8 0.2 1.7e-20 73.9 0.2 3.3 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 ORX45720.1 - 4.9e-19 68.1 1.8 4.9e-19 68.1 1.8 2.3 2 0 0 2 2 2 1 PUA domain UPF0113 PF03657.13 ORX45720.1 - 0.0087 16.3 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 1 UPF0113 PUA domain Sdh_cyt PF01127.22 ORX45721.1 - 1.1e-23 83.5 2.4 1.5e-23 83.1 2.4 1.2 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DOT1 PF08123.13 ORX45722.1 - 2e-08 34.0 0.1 3.6e-08 33.2 0.1 1.4 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 ORX45722.1 - 5.7e-06 26.2 0.2 7.2e-06 25.9 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX45722.1 - 3.8e-05 24.3 0.1 6.5e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX45722.1 - 0.0071 16.2 0.0 0.0089 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ORX45722.1 - 0.011 15.3 0.1 0.016 14.8 0.1 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 ORX45722.1 - 0.011 15.7 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ORX45722.1 - 0.016 14.6 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX45722.1 - 0.048 13.2 0.2 0.068 12.7 0.2 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 ORX45722.1 - 0.059 12.4 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase FtsJ PF01728.19 ORX45722.1 - 0.069 13.3 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_12 PF08242.12 ORX45722.1 - 0.08 13.7 0.1 0.13 13.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ORX45722.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 ORX45722.1 - 0.12 11.4 0.8 0.91 8.6 0.8 1.9 1 1 0 1 1 1 0 DREV methyltransferase F-box-like PF12937.7 ORX45723.1 - 3.5e-10 39.6 2.0 8.2e-10 38.4 2.0 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX45723.1 - 5e-06 26.2 1.1 1.2e-05 25.1 1.1 1.7 1 0 0 1 1 1 1 F-box domain HPS3_N PF14761.6 ORX45723.1 - 0.12 11.9 0.0 9 5.8 0.0 2.4 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 UBX PF00789.20 ORX45724.1 - 8.3e-15 54.8 0.0 1.8e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ORX45724.1 - 8.3e-12 44.7 0.6 1.5e-11 43.9 0.6 1.5 1 0 0 1 1 1 1 UBA-like domain SUB1_ProdP9 PF18213.1 ORX45724.1 - 0.13 12.1 0.0 0.34 10.8 0.0 1.7 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Thioredoxin_7 PF13899.6 ORX45724.1 - 0.15 12.2 0.1 0.36 11.1 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin-like Phage_Treg PF04761.12 ORX45725.1 - 0.088 12.9 0.2 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator Hyr1 PF15789.5 ORX45725.1 - 0.12 12.0 1.4 0.2 11.3 0.6 1.9 2 0 0 2 2 2 0 Hyphally regulated cell wall GPI-anchored protein 1 zf-C2H2_4 PF13894.6 ORX45725.1 - 0.16 12.9 8.9 2.9 9.0 1.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX45725.1 - 0.35 11.4 7.0 0.96 10.0 2.0 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type CpXC PF14353.6 ORX45725.1 - 0.39 10.8 2.0 8.2 6.5 2.0 2.5 1 1 0 1 1 1 0 CpXC protein zf-C2H2_6 PF13912.6 ORX45725.1 - 0.45 10.6 4.7 2.7 8.1 1.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX45725.1 - 0.69 10.5 12.6 13 6.4 6.3 3.3 2 1 0 2 2 2 0 Zinc-finger double domain Ribosomal_60s PF00428.19 ORX45726.1 - 3.9e-26 91.4 10.1 4.6e-26 91.2 10.1 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein EF-hand_14 PF17959.1 ORX45726.1 - 0.0035 17.7 0.0 0.0052 17.1 0.0 1.2 1 0 0 1 1 1 1 EF-hand domain PX PF00787.24 ORX45727.1 - 4.1e-18 65.4 0.4 1.4e-17 63.7 0.4 1.9 1 0 0 1 1 1 1 PX domain Rsd_AlgQ PF04353.13 ORX45727.1 - 0.76 9.7 4.1 7.5 6.5 0.2 3.1 3 0 0 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ TelA PF05816.11 ORX45727.1 - 0.81 8.7 4.4 1.3 8.0 0.6 2.2 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) RasGEF PF00617.19 ORX45728.1 - 2.2e-30 106.2 3.0 2.4e-30 106.0 1.2 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ORX45728.1 - 0.00085 19.5 0.1 0.00085 19.5 0.1 2.7 3 0 0 3 3 3 1 RasGEF N-terminal motif Nucleotid_trans PF03407.16 ORX45729.1 - 1.4e-15 57.8 0.1 2.4e-15 57.1 0.1 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase UDPGP PF01704.18 ORX45730.1 - 8.5e-59 199.2 0.0 1.2e-58 198.8 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 ORX45730.1 - 0.057 13.8 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 MobA-like NTP transferase domain OrsD PF12013.8 ORX45732.1 - 2.1e-11 44.3 2.9 2.1e-11 44.3 2.9 1.9 2 0 0 2 2 2 1 Orsellinic acid/F9775 biosynthesis cluster protein D Pribosyltran PF00156.27 ORX45732.1 - 0.083 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase domain zf-C2H2_12 PF18658.1 ORX45732.1 - 0.36 10.4 2.6 1.2 8.8 2.6 1.9 1 0 0 1 1 1 0 Zinc-finger C2H2-type UPF0139 PF03669.13 ORX45831.1 - 6.5e-10 38.7 0.0 8.1e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) CopD PF05425.13 ORX45831.1 - 0.025 15.0 0.1 0.04 14.3 0.1 1.3 1 1 0 1 1 1 0 Copper resistance protein D Nop14 PF04147.12 ORX45832.1 - 9.7e-267 887.7 31.4 1.1e-266 887.4 31.4 1.0 1 0 0 1 1 1 1 Nop14-like family LSM14 PF12701.7 ORX45833.1 - 3.2e-30 104.1 0.1 6.9e-30 103.0 0.1 1.6 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 ORX45833.1 - 2e-14 54.3 3.6 2e-14 54.3 3.6 2.8 2 2 0 2 2 2 1 FDF domain SM-ATX PF14438.6 ORX45833.1 - 3e-07 30.5 0.1 7e-07 29.3 0.1 1.6 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF4110 PF13422.6 ORX45833.1 - 0.059 13.5 0.1 0.14 12.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4110) Paramyxo_ncap PF00973.19 ORX45833.1 - 0.81 8.5 5.0 1.3 7.9 5.0 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Abhydrolase_6 PF12697.7 ORX45835.1 - 0.00073 20.2 0.6 0.00088 19.9 0.6 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX45835.1 - 0.0024 17.2 0.3 0.0032 16.8 0.3 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 ORX45835.1 - 0.033 13.8 0.2 0.64 9.6 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Phage_holin_2_1 PF04971.12 ORX45835.1 - 0.11 12.6 0.3 0.25 11.4 0.2 1.7 2 0 0 2 2 2 0 Bacteriophage P21 holin S Phage_holin_2_3 PF16080.5 ORX45835.1 - 0.21 11.4 0.8 0.54 10.0 0.2 2.1 2 1 0 2 2 2 0 Bacteriophage holin family HP1 Y_phosphatase3 PF13350.6 ORX45836.1 - 2.4e-16 60.4 0.1 9.5e-14 51.9 0.1 2.1 1 1 0 1 1 1 1 Tyrosine phosphatase family Xan_ur_permease PF00860.20 ORX45838.1 - 1.9e-62 211.2 38.8 2.5e-62 210.8 38.8 1.2 1 0 0 1 1 1 1 Permease family PMP22_Claudin PF00822.20 ORX45838.1 - 0.13 12.1 6.9 0.26 11.1 0.4 2.7 2 1 0 2 2 2 0 PMP-22/EMP/MP20/Claudin family MFS_MOT1 PF16983.5 ORX45838.1 - 0.68 10.4 30.1 0.054 13.9 5.9 3.3 4 0 0 4 4 4 0 Molybdate transporter of MFS superfamily MBOAT_2 PF13813.6 ORX45839.1 - 1.1e-19 70.5 1.3 2.6e-19 69.3 1.3 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family Pkinase PF00069.25 ORX45841.1 - 3.7e-62 210.1 0.0 2.6e-61 207.3 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX45841.1 - 6.5e-29 101.0 0.0 2.8e-22 79.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX45841.1 - 3e-07 29.7 0.1 3.9e-07 29.3 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX45841.1 - 0.00013 21.4 0.4 0.0011 18.3 0.0 2.3 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX45841.1 - 0.00019 21.5 2.9 0.18 11.7 0.1 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX45841.1 - 0.00021 20.7 0.1 0.012 14.9 0.0 2.5 2 1 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 ORX45841.1 - 0.0054 17.4 0.1 0.013 16.2 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Seadorna_VP7 PF07387.11 ORX45841.1 - 0.016 14.3 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 ORX45841.1 - 0.046 12.5 0.3 0.082 11.7 0.3 1.5 1 1 0 1 1 1 0 Fungal protein kinase PolC_DP2 PF03833.13 ORX45841.1 - 0.16 9.8 0.0 0.25 9.2 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 RIO1 PF01163.22 ORX45841.1 - 0.21 11.2 1.2 0.23 11.1 0.0 1.6 2 0 0 2 2 2 0 RIO1 family DHHC PF01529.20 ORX45842.1 - 3.8e-36 124.2 12.1 3.8e-36 124.2 12.1 2.5 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 ORX45842.1 - 3.2e-30 104.5 3.3 1.7e-15 57.4 0.8 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX45842.1 - 7.1e-29 99.8 7.0 7.4e-07 29.6 0.2 5.2 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX45842.1 - 5.5e-27 93.5 9.0 4.2e-06 26.9 0.1 4.8 2 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ORX45842.1 - 9.6e-24 82.7 9.4 4e-05 23.9 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_3 PF13606.6 ORX45842.1 - 2.1e-23 79.9 5.8 0.00028 21.1 0.1 6.5 6 0 0 6 6 6 5 Ankyrin repeat OrfB_Zn_ribbon PF07282.11 ORX45843.1 - 2.5e-07 30.5 0.1 3.5e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain CybS PF05328.12 ORX45844.1 - 1.5e-37 128.2 0.0 1.7e-37 128.1 0.0 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 ORX45844.1 - 0.076 13.1 0.1 2.5 8.2 0.0 2.1 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DTW PF03942.15 ORX45845.1 - 4.9e-33 114.5 0.0 8.8e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 DTW domain zf-P11 PF03854.14 ORX45845.1 - 0.73 9.5 3.9 1.2 8.9 1.0 2.0 1 1 1 2 2 2 0 P-11 zinc finger Glyco_hydro_20 PF00728.22 ORX45846.1 - 3.4e-92 309.6 0.2 4.2e-92 309.3 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX45846.1 - 3.2e-17 63.5 0.0 6.1e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX45846.1 - 9.5e-07 29.6 0.1 1.7e-06 28.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 GHL6 PF14871.6 ORX45846.1 - 0.029 14.5 0.0 0.059 13.5 0.0 1.5 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 NODP PF07684.12 ORX45846.1 - 0.055 13.6 0.0 5.5 7.2 0.0 2.4 2 0 0 2 2 2 0 NOTCH protein MCM PF00493.23 ORX45847.1 - 2.6e-96 321.1 0.1 4.5e-96 320.3 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX45847.1 - 7.1e-34 116.4 0.0 1.2e-33 115.6 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX45847.1 - 2.2e-22 79.3 3.0 4.7e-22 78.2 3.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX45847.1 - 9.1e-11 42.3 0.0 3.1e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX45847.1 - 1e-07 31.6 0.0 1.7e-06 27.6 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX45847.1 - 0.0027 17.6 0.0 0.0058 16.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX45847.1 - 0.013 15.2 0.0 0.034 13.8 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 ORX45847.1 - 0.026 14.5 0.0 0.072 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) LMBR1 PF04791.16 ORX45847.1 - 0.39 9.6 2.2 0.72 8.7 1.8 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein PDCD2_C PF04194.13 ORX45847.1 - 1.8 8.6 5.9 26 4.8 0.0 2.6 2 1 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain DUF5523 PF17661.1 ORX45847.1 - 3.6 7.2 9.5 5.9 6.5 9.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) OrfB_Zn_ribbon PF07282.11 ORX45849.1 - 7.2e-09 35.4 0.8 2e-08 34.0 0.8 1.8 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX45849.1 - 0.03 14.3 1.4 0.067 13.2 1.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF4407 PF14362.6 ORX45849.1 - 0.33 10.2 7.1 1.3 8.3 2.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) RNHCP PF12647.7 ORX45849.1 - 1.1 9.2 4.1 0.39 10.7 0.9 1.9 2 0 0 2 2 2 0 RNHCP domain EF-hand_4 PF12763.7 ORX45850.1 - 1.7e-39 134.0 0.0 2.6e-17 62.7 0.0 3.5 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ORX45850.1 - 1.3e-11 43.2 0.1 0.0019 17.6 0.0 4.5 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 ORX45850.1 - 7.8e-09 35.9 0.8 0.0044 17.4 0.0 4.7 3 1 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX45850.1 - 8.3e-07 28.4 0.4 0.17 11.9 0.0 4.9 5 0 0 5 5 4 2 EF-hand domain CENP-Q PF13094.6 ORX45850.1 - 3.3e-05 24.2 9.1 8.8e-05 22.8 9.1 1.7 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit EF-hand_8 PF13833.6 ORX45850.1 - 0.0016 18.3 0.1 3.1 7.7 0.0 4.2 3 1 2 5 5 5 1 EF-hand domain pair ATG16 PF08614.11 ORX45850.1 - 0.0028 17.9 13.0 0.0072 16.6 13.0 1.7 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) WEMBL PF05701.11 ORX45850.1 - 0.0062 15.3 7.7 0.01 14.6 7.7 1.2 1 0 0 1 1 1 1 Weak chloroplast movement under blue light AAA_13 PF13166.6 ORX45850.1 - 0.019 13.6 6.8 0.028 13.1 6.8 1.1 1 0 0 1 1 1 0 AAA domain APG6_N PF17675.1 ORX45850.1 - 0.037 14.6 13.1 0.073 13.6 13.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Spc7 PF08317.11 ORX45850.1 - 0.048 12.5 12.5 0.077 11.9 12.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.9 ORX45850.1 - 0.05 12.6 8.6 0.077 11.9 8.6 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Med9 PF07544.13 ORX45850.1 - 0.066 13.3 9.4 0.16 12.1 9.4 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 HAUS-augmin3 PF14932.6 ORX45850.1 - 0.082 12.5 10.2 0.14 11.7 10.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 ADIP PF11559.8 ORX45850.1 - 0.13 12.4 12.2 0.23 11.5 12.2 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding EF-hand_5 PF13202.6 ORX45850.1 - 0.13 11.8 0.2 1.3 8.6 0.0 2.7 2 0 0 2 2 2 0 EF hand Cluap1 PF10234.9 ORX45850.1 - 0.14 11.5 14.4 0.022 14.2 3.1 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 TMEM215 PF15746.5 ORX45850.1 - 0.17 11.3 1.1 0.97 8.9 1.0 2.0 2 0 0 2 2 2 0 TMEM215 family DUF4407 PF14362.6 ORX45850.1 - 0.21 10.9 10.4 0.34 10.2 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 ORX45850.1 - 0.24 11.5 13.0 0.44 10.6 13.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ORX45850.1 - 0.31 10.1 9.9 0.75 8.8 9.9 1.6 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 ORX45850.1 - 0.35 10.9 18.8 0.36 10.9 10.3 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4559 PF15112.6 ORX45850.1 - 0.73 9.5 8.4 1.1 8.9 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) DUF1664 PF07889.12 ORX45850.1 - 0.82 9.7 5.7 1.7 8.7 5.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FapA PF03961.13 ORX45850.1 - 2 7.0 8.0 2.9 6.4 8.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF641 PF04859.12 ORX45850.1 - 2.2 8.6 14.2 3.2 8.1 3.0 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FAM76 PF16046.5 ORX45850.1 - 2.4 7.5 8.3 3.8 6.8 8.3 1.3 1 0 0 1 1 1 0 FAM76 protein YabA PF06156.13 ORX45850.1 - 3.3 8.4 6.7 7.2 7.3 6.7 1.5 1 0 0 1 1 1 0 Initiation control protein YabA PPR PF01535.20 ORX45851.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 PPR repeat RPN7 PF10602.9 ORX45851.1 - 0.07 12.8 0.1 0.11 12.2 0.1 1.2 1 0 0 1 1 1 0 26S proteasome subunit RPN7 Tmemb_14 PF03647.13 ORX45852.1 - 8.5e-26 90.5 4.3 9.7e-26 90.3 4.3 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 ORX45852.1 - 0.015 15.6 0.5 0.065 13.5 0.5 1.8 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 19 DUF308 PF03729.13 ORX45852.1 - 0.15 12.4 3.7 1.1 9.7 0.9 2.3 2 1 0 2 2 2 0 Short repeat of unknown function (DUF308) Zn_clus PF00172.18 ORX45853.1 - 4.9e-06 26.6 12.2 8.8e-06 25.8 12.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Choline_transpo PF04515.12 ORX45854.1 - 1.5e-75 254.4 39.2 1.5e-75 254.4 39.2 2.1 1 1 1 2 2 2 1 Plasma-membrane choline transporter Sin3_corepress PF08295.12 ORX45855.1 - 1.2e-27 95.9 0.2 2.3e-27 94.9 0.2 1.5 1 0 0 1 1 1 1 Sin3 family co-repressor Sin3a_C PF16879.5 ORX45855.1 - 1.8e-16 60.7 0.0 3.9e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein PH PF00169.29 ORX45856.1 - 3e-15 56.6 0.4 4.6e-15 56.0 0.4 1.2 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ORX45856.1 - 0.023 15.1 0.2 0.2 12.1 0.2 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain ATP-synt_S1 PF05827.12 ORX45857.1 - 0.0029 17.4 2.3 0.0042 16.9 1.5 1.4 1 1 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) LapA_dom PF06305.11 ORX45857.1 - 0.5 10.2 2.0 1.2 9.0 2.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Band_7 PF01145.25 ORX45858.1 - 1.4e-23 83.9 3.2 1.4e-23 83.9 3.2 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family Peptidase_S66 PF02016.15 ORX45858.1 - 0.015 15.4 0.3 0.055 13.6 0.3 2.0 1 1 1 2 2 2 0 LD-carboxypeptidase N-terminal domain DUF1378 PF07125.11 ORX45858.1 - 0.063 13.4 1.0 10 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1378) Zn_clus PF00172.18 ORX45860.1 - 4.8e-12 45.8 22.6 4.3e-06 26.7 9.4 2.5 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain IP_trans PF02121.18 ORX45861.1 - 5.2e-105 350.5 0.0 5.9e-105 350.3 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein DUF1712 PF08217.11 ORX45862.1 - 2.7e-25 88.9 0.4 2.7e-25 88.9 0.4 1.6 2 0 0 2 2 2 1 Fungal domain of unknown function (DUF1712) Glyco_hydro_3_C PF01915.22 ORX45863.1 - 5.8e-53 179.9 0.0 8.3e-53 179.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ORX45863.1 - 1.4e-44 152.8 0.0 2.1e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ORX45863.1 - 2.9e-23 81.8 0.0 6.4e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain MT-A70 PF05063.14 ORX45864.1 - 9.8e-06 25.6 0.0 1.2e-05 25.3 0.0 1.1 1 0 0 1 1 1 1 MT-A70 Myb_DNA-binding PF00249.31 ORX45865.1 - 0.2 11.9 2.8 0.42 10.8 1.5 2.2 2 1 0 2 2 2 0 Myb-like DNA-binding domain LRR_4 PF12799.7 ORX45866.1 - 2.8e-15 56.2 34.9 4e-08 33.4 4.8 3.9 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX45866.1 - 2.2e-12 46.6 26.2 1.1e-09 37.9 12.4 3.0 2 2 2 4 4 4 3 Leucine rich repeat LRR_6 PF13516.6 ORX45866.1 - 3.5e-07 29.7 21.9 0.042 13.9 1.2 4.7 4 0 0 4 4 4 4 Leucine Rich repeat LRR_1 PF00560.33 ORX45866.1 - 3e-06 27.0 19.2 0.14 12.8 0.9 5.7 5 1 0 5 5 5 3 Leucine Rich Repeat BRCA2 PF00634.18 ORX45866.1 - 0.017 14.8 0.0 0.045 13.4 0.0 1.7 1 0 0 1 1 1 0 BRCA2 repeat DUF1387 PF07139.11 ORX45866.1 - 0.15 11.8 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4442 PF14539.6 ORX45869.1 - 1.3e-23 83.6 0.0 1.7e-23 83.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) MTA_R1 PF17226.2 ORX45869.1 - 0.0018 18.4 0.1 0.0032 17.6 0.1 1.5 1 0 0 1 1 1 1 MTA R1 domain 4HBT PF03061.22 ORX45869.1 - 0.0059 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily GIDA PF01134.22 ORX45870.1 - 1e-153 512.1 0.0 1.3e-153 511.8 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 ORX45870.1 - 2.5e-67 227.1 0.0 4.1e-67 226.4 0.0 1.4 1 0 0 1 1 1 1 GidA associated domain FAD_oxidored PF12831.7 ORX45870.1 - 1.6e-08 34.4 0.1 3e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX45870.1 - 2.7e-05 23.6 1.0 0.00031 20.1 0.8 2.6 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ORX45870.1 - 0.0002 20.8 0.1 0.0004 19.8 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ORX45870.1 - 0.00023 20.4 0.7 0.0005 19.3 0.7 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ORX45870.1 - 0.0011 17.7 1.6 0.024 13.4 0.5 2.5 2 0 0 2 2 2 1 HI0933-like protein K_oxygenase PF13434.6 ORX45870.1 - 0.13 11.3 0.1 0.46 9.6 0.1 1.9 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 ORX45870.1 - 0.14 11.4 0.0 0.57 9.4 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Fungal_trans PF04082.18 ORX45871.1 - 8.4e-11 41.4 0.0 8.4e-11 41.4 0.0 2.2 3 1 0 3 3 3 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX45871.1 - 0.00016 21.7 9.4 0.00031 20.8 9.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2019 PF09450.10 ORX45871.1 - 0.062 13.3 0.2 0.18 11.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2019) Rab5-bind PF09311.11 ORX45871.1 - 0.063 12.7 1.0 0.096 12.1 1.0 1.2 1 0 0 1 1 1 0 Rabaptin-like protein DASH_Dam1 PF08653.10 ORX45871.1 - 0.063 13.1 0.3 0.17 11.7 0.3 1.8 1 0 0 1 1 1 0 DASH complex subunit Dam1 Sec34 PF04136.15 ORX45871.1 - 0.18 11.7 3.1 0.27 11.1 2.3 1.7 2 0 0 2 2 2 0 Sec34-like family Tropomyosin_1 PF12718.7 ORX45871.1 - 0.26 11.4 0.6 0.41 10.8 0.6 1.2 1 0 0 1 1 1 0 Tropomyosin like ATG16 PF08614.11 ORX45871.1 - 0.27 11.4 1.5 0.53 10.5 1.5 1.5 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Macoilin PF09726.9 ORX45871.1 - 0.64 8.5 3.1 0.98 7.9 3.1 1.2 1 0 0 1 1 1 0 Macoilin family bZIP_2 PF07716.15 ORX45871.1 - 0.73 10.0 2.6 2.5 8.2 0.5 2.3 2 0 0 2 2 2 0 Basic region leucine zipper Thaumatin PF00314.17 ORX45872.1 - 5.1e-50 170.1 12.0 6.4e-50 169.8 12.0 1.1 1 0 0 1 1 1 1 Thaumatin family Tryp_inh PF17983.1 ORX45872.1 - 9.4 6.4 12.2 0.91 9.7 6.5 2.3 2 0 0 2 2 2 0 Trypsin inhibitors 1,2 and 3 PIG-X PF08320.12 ORX45874.1 - 2.1e-31 109.5 4.2 8.6e-31 107.5 4.2 1.7 1 1 0 1 1 1 1 PIG-X / PBN1 VHS PF00790.19 ORX45875.1 - 1.6e-38 131.8 0.8 3.2e-38 130.7 0.0 1.9 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 ORX45875.1 - 3.9e-17 62.2 8.0 3.9e-17 62.2 8.0 1.8 2 0 0 2 2 1 1 FYVE zinc finger UIM PF02809.20 ORX45875.1 - 6e-07 28.9 5.5 0.0071 16.2 0.2 2.8 2 0 0 2 2 2 2 Ubiquitin interaction motif GAT PF03127.14 ORX45875.1 - 9.2e-06 25.9 0.5 3.5e-05 24.0 0.1 2.2 2 0 0 2 2 2 1 GAT domain FYVE_2 PF02318.16 ORX45875.1 - 0.00023 21.3 2.7 0.00023 21.3 2.7 1.8 2 0 0 2 2 1 1 FYVE-type zinc finger DZR PF12773.7 ORX45875.1 - 0.13 12.3 10.4 2.2 8.3 3.1 2.5 1 1 1 2 2 2 0 Double zinc ribbon EPL1 PF10513.9 ORX45875.1 - 0.36 11.2 11.3 1.1 9.6 11.3 1.8 1 0 0 1 1 1 0 Enhancer of polycomb-like Presenilin PF01080.17 ORX45875.1 - 0.56 8.9 12.5 1 8.1 12.5 1.3 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 ORX45875.1 - 1.4 9.0 7.2 3.9 7.6 7.2 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 ORX45875.1 - 2.2 7.7 14.0 4.1 6.8 14.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) AIF_C PF14721.6 ORX45875.1 - 4.2 7.7 8.8 12 6.3 8.8 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term eIF-3_zeta PF05091.12 ORX45875.1 - 5 6.0 16.2 7.5 5.4 16.2 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Connexin PF00029.19 ORX45875.1 - 5 6.8 7.6 8.5 6.1 7.6 1.3 1 0 0 1 1 1 0 Connexin Gti1_Pac2 PF09729.9 ORX45875.1 - 8 6.5 8.4 24 5.0 8.4 1.8 1 0 0 1 1 1 0 Gti1/Pac2 family SAGA-Tad1 PF12767.7 ORX45875.1 - 8.5 6.0 14.5 15 5.2 8.5 2.6 2 1 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Glyco_hydro_16 PF00722.21 ORX45876.1 - 6.3e-22 77.9 0.0 8e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 F-box-like PF12937.7 ORX45877.1 - 2.4e-06 27.3 0.3 9.3e-06 25.4 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box_4 PF15966.5 ORX45877.1 - 1.9e-05 24.5 0.4 5.2e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 F-box F-box PF00646.33 ORX45877.1 - 0.0015 18.3 0.1 0.004 17.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain DUF2443 PF10398.9 ORX45877.1 - 0.0094 16.0 0.0 0.11 12.6 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2443) PI3_PI4_kinase PF00454.27 ORX45879.1 - 1.7e-46 159.1 0.0 3.1e-46 158.2 0.0 1.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DnaJ PF00226.31 ORX45880.1 - 3.5e-27 94.3 1.6 5.2e-27 93.8 1.6 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 ORX45880.1 - 4.7e-21 75.4 0.0 6.6e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain RPT PF13446.6 ORX45880.1 - 0.071 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 A repeated domain in UCH-protein PseudoU_synth_1 PF01416.20 ORX45882.1 - 9.1e-13 48.6 0.0 3.6e-10 40.3 0.0 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase DUF2344 PF10105.9 ORX45882.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) AbrB-like PF14250.6 ORX45882.1 - 0.055 13.6 0.0 0.16 12.1 0.0 1.8 1 0 0 1 1 1 0 AbrB-like transcriptional regulator Acyltransferase PF01553.21 ORX45883.1 - 3.4e-06 26.7 0.0 2.6e-05 23.9 0.0 2.2 2 0 0 2 2 2 1 Acyltransferase Glyco_hydro_3_C PF01915.22 ORX45884.1 - 9.6e-59 198.8 0.0 2e-58 197.7 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ORX45884.1 - 1.9e-40 139.2 0.0 3.6e-40 138.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ORX45884.1 - 3.2e-18 65.6 0.0 6e-18 64.7 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Alpha-amyl_C PF09071.10 ORX45884.1 - 0.053 13.4 0.0 18 5.2 0.0 2.9 3 0 0 3 3 3 0 Alpha-amylase, C terminal SHD1 PF03983.12 ORX45885.1 - 8.4e-15 54.3 0.0 1.5e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 F-box-like PF12937.7 ORX45885.1 - 0.0022 17.8 0.3 0.0065 16.3 0.3 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX45885.1 - 0.011 15.6 0.7 0.047 13.6 0.5 2.1 2 0 0 2 2 2 0 F-box domain F-box_4 PF15966.5 ORX45885.1 - 0.055 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 F-box TFIIA PF03153.13 ORX45885.1 - 2.5 8.0 9.1 3.8 7.4 9.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YjeF_N PF03853.15 ORX45886.1 - 1.2e-41 142.4 0.0 1.5e-41 142.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Chorismate_bind PF00425.18 ORX45887.1 - 5.3e-86 288.4 0.0 7.7e-86 287.8 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 ORX45887.1 - 2.2e-32 112.4 0.2 5.8e-21 75.1 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 ORX45887.1 - 2.3e-11 44.1 0.1 4.6e-10 39.9 0.1 2.6 1 1 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 ORX45887.1 - 0.0019 18.0 2.8 0.031 14.0 2.8 2.3 1 1 0 1 1 1 1 Peptidase C26 Croc_4 PF17691.1 ORX45887.1 - 0.053 13.6 1.5 0.16 12.0 0.1 2.5 2 0 0 2 2 2 0 Contingent replication of cDNA 4 WD40 PF00400.32 ORX45888.1 - 1e-61 203.4 10.0 6.3e-10 39.5 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ORX45888.1 - 1.3e-26 92.7 11.5 1.9e-26 92.2 11.5 1.2 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ORX45888.1 - 1.2e-21 76.8 0.0 4.4e-05 23.7 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX45888.1 - 6e-09 35.7 0.0 0.0081 15.5 0.0 5.1 5 1 1 6 6 6 1 WD40-like domain Ge1_WD40 PF16529.5 ORX45888.1 - 9.4e-08 31.4 0.0 0.3 10.0 0.0 4.6 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ORX45888.1 - 0.00024 19.8 0.4 0.1 11.1 0.2 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ORX45888.1 - 0.00025 20.9 0.1 0.85 9.6 0.0 4.6 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ORX45888.1 - 0.00041 19.1 0.1 2.5 6.7 0.0 3.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 SHE3 PF17078.5 ORX45888.1 - 0.00045 20.0 5.5 0.00067 19.4 5.5 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Ret2_MD PF18528.1 ORX45888.1 - 0.0019 18.5 0.0 0.093 13.1 0.0 3.2 3 0 0 3 3 3 1 RNA editing 3' terminal uridylyl transferase 2 middle domain Nbas_N PF15492.6 ORX45888.1 - 0.002 17.5 0.1 4.7 6.5 0.0 3.2 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Jnk-SapK_ap_N PF09744.9 ORX45888.1 - 0.0031 17.8 6.5 0.0051 17.1 6.5 1.2 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 MMS1_N PF10433.9 ORX45888.1 - 0.035 12.7 0.0 1.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Peptidase_S9_N PF02897.15 ORX45888.1 - 0.04 12.7 0.0 1.1 8.0 0.0 2.3 2 1 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain nos_propeller PF18764.1 ORX45888.1 - 0.074 13.0 0.0 8.9 6.3 0.0 3.4 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Golgin_A5 PF09787.9 ORX45888.1 - 0.3 10.5 10.9 0.45 9.9 10.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.11 ORX45888.1 - 0.56 9.0 9.4 0.78 8.6 9.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein CREPT PF16566.5 ORX45888.1 - 0.57 10.3 5.9 0.87 9.8 5.9 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour TPX2 PF06886.11 ORX45888.1 - 0.98 9.7 7.2 1.8 8.9 7.2 1.3 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DUF5122 PF17164.4 ORX45888.1 - 2 8.7 4.6 36 4.7 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller Clat_adaptor_s PF01217.20 ORX45889.1 - 8.2e-56 187.9 3.4 9.1e-56 187.7 3.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PCAF_N PF06466.11 ORX45889.1 - 0.0093 15.6 0.1 0.011 15.3 0.1 1.2 1 0 0 1 1 1 1 PCAF (P300/CBP-associated factor) N-terminal domain Fungal_trans PF04082.18 ORX45891.1 - 7.6e-27 94.0 0.0 1.8e-26 92.8 0.0 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX45891.1 - 4.1e-10 39.6 13.4 8.1e-10 38.7 13.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MNNL PF07657.13 ORX45892.1 - 0.045 13.8 0.1 0.062 13.3 0.1 1.2 1 0 0 1 1 1 0 N terminus of Notch ligand DUF2615 PF11027.8 ORX45892.1 - 0.05 13.7 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) ADH_zinc_N PF00107.26 ORX45893.1 - 1.5e-20 73.5 0.4 3.2e-20 72.4 0.1 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX45893.1 - 1.1e-19 70.3 0.0 2.2e-19 69.4 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX45893.1 - 4.1e-07 31.1 0.0 1.1e-06 29.8 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ORX45894.1 - 2.1e-20 73.0 0.1 4.6e-20 71.9 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ORX45894.1 - 3.6e-17 62.2 0.0 7.8e-17 61.1 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 ORX45894.1 - 3.2e-09 38.0 0.0 6.6e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase GerPB PF10803.8 ORX45894.1 - 0.14 12.3 0.0 6.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Spore germination GerPB BCAS2 PF05700.11 ORX45895.1 - 8.9e-66 221.5 11.8 9.9e-66 221.4 11.8 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) IL11 PF07400.11 ORX45895.1 - 0.0039 16.9 0.6 0.007 16.0 0.6 1.4 1 0 0 1 1 1 1 Interleukin 11 Shugoshin_N PF07558.11 ORX45895.1 - 0.023 14.5 0.3 2.8 7.9 0.0 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region APG6_N PF17675.1 ORX45895.1 - 3.9 8.0 15.2 0.13 12.8 7.6 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region Enkurin PF13864.6 ORX45895.1 - 6.5 7.3 12.0 0.39 11.2 3.1 2.6 2 1 0 2 2 2 0 Calmodulin-binding LSM PF01423.22 ORX45897.1 - 2.8e-21 75.0 0.3 3.1e-21 74.8 0.3 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX45897.1 - 0.0063 16.6 0.0 0.0078 16.3 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 ORX45897.1 - 0.026 14.6 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 RimP C-terminal SH3 domain LSM14 PF12701.7 ORX45897.1 - 0.075 13.1 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain BAR_3 PF16746.5 ORX45898.1 - 4e-31 108.6 4.2 7.3e-31 107.7 4.2 1.4 1 0 0 1 1 1 1 BAR domain of APPL family VASt PF16016.5 ORX45898.1 - 2.2e-29 102.8 2.1 1.4e-28 100.3 0.0 2.6 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain PH PF00169.29 ORX45898.1 - 6.5e-12 45.9 0.1 2.5e-11 44.0 0.1 2.0 1 0 0 1 1 1 1 PH domain BAR PF03114.18 ORX45898.1 - 0.0064 16.2 3.9 0.0064 16.2 3.9 2.1 2 1 0 2 2 2 1 BAR domain HDAC4_Gln PF12203.8 ORX45898.1 - 2.2 8.5 5.8 6.3 7.0 5.8 1.7 1 0 0 1 1 1 0 Glutamine rich N terminal domain of histone deacetylase 4 Suf PF05843.14 ORX45898.1 - 8 6.4 16.7 0.064 13.2 4.0 2.4 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) FANCI_S1-cap PF14674.6 ORX45899.1 - 0.068 13.3 3.5 0.096 12.8 1.2 2.5 2 0 0 2 2 2 0 FANCI solenoid 1 cap DnaJ PF00226.31 ORX45900.1 - 2.2e-19 69.3 3.0 8.6e-19 67.4 3.0 2.1 1 0 0 1 1 1 1 DnaJ domain PepX_N PF09168.10 ORX45900.1 - 0.27 11.7 7.5 1.5 9.3 2.6 2.6 2 0 0 2 2 2 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal NifQ PF04891.12 ORX45900.1 - 3.7 7.9 6.8 1.8 8.9 1.7 2.4 2 1 1 3 3 3 0 NifQ CotH PF08757.11 ORX45901.1 - 5.7e-33 114.8 0.0 7.3e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 CotH kinase protein Dus PF01207.17 ORX45902.1 - 2.8e-56 190.9 0.3 5.4e-56 190.0 0.3 1.5 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) FMN_dh PF01070.18 ORX45902.1 - 0.039 13.0 0.4 0.16 11.0 0.4 1.7 1 1 0 1 1 1 0 FMN-dependent dehydrogenase Phage_holin_5_2 PF16079.5 ORX45903.1 - 0.021 15.1 2.0 0.052 13.9 2.0 1.7 1 1 0 1 1 1 0 Phage holin family Hol44, in holin superfamily V BK_channel_a PF03493.18 ORX45903.1 - 0.029 14.6 0.2 0.037 14.2 0.2 1.2 1 0 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit Lipase_GDSL PF00657.22 ORX45907.1 - 9.7e-05 22.4 1.2 0.0003 20.8 1.4 1.8 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase TPR_1 PF00515.28 ORX45907.1 - 0.05 13.4 0.5 0.4 10.6 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2433 PF10360.9 ORX45908.1 - 6.1e-41 139.4 0.0 1e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2433) RRM_1 PF00076.22 ORX45908.1 - 1.2e-10 41.0 0.0 2.4e-10 40.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Metallophos PF00149.28 ORX45908.1 - 0.0002 21.9 0.0 0.00043 20.9 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_7 PF16367.5 ORX45908.1 - 0.024 14.8 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Metallophos_3 PF14582.6 ORX45908.1 - 0.076 12.3 0.0 11 5.3 0.0 2.3 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily Asp PF00026.23 ORX45909.1 - 1.5e-107 359.7 0.7 3.8e-105 351.8 0.7 2.1 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX45909.1 - 3.5e-12 46.9 0.2 4.2e-10 40.1 0.2 2.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX45909.1 - 0.033 14.8 0.0 9.5 6.9 0.0 2.8 2 1 0 2 2 2 0 Aspartyl protease Ribosomal_L37e PF01907.19 ORX45910.1 - 2.8e-27 94.6 12.0 4.6e-27 93.9 12.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 ORX45910.1 - 0.0076 16.3 1.6 0.011 15.7 1.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 ORX45910.1 - 0.028 14.4 0.9 0.038 14.0 0.9 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_5 PF14634.6 ORX45910.1 - 0.051 13.5 4.0 0.077 13.0 4.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX45910.1 - 0.4 10.6 5.0 0.63 9.9 5.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX45910.1 - 0.5 10.3 4.6 0.78 9.7 4.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WAC_Acf1_DNA_bd PF10537.9 ORX45912.1 - 1.2e-28 99.6 0.1 4e-28 97.9 0.1 2.0 1 0 0 1 1 1 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 ORX45912.1 - 2.8e-21 75.8 0.0 2.8e-21 75.8 0.0 3.4 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 ORX45912.1 - 3.9e-20 71.9 1.4 8.5e-20 70.8 1.4 1.6 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 ORX45912.1 - 0.029 13.9 0.1 0.07 12.7 0.1 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Ndc1_Nup PF09531.10 ORX45912.1 - 0.69 8.5 5.8 1.3 7.7 5.8 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CCDC-167 PF15188.6 ORX45912.1 - 1.4 9.3 17.5 0.59 10.5 0.6 3.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DivIC PF04977.15 ORX45912.1 - 9.1 6.1 16.5 13 5.7 8.0 3.0 2 0 0 2 2 2 0 Septum formation initiator Fe-ADH PF00465.19 ORX45913.1 - 1.5e-107 359.6 0.1 2e-107 359.2 0.1 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ORX45913.1 - 1.2e-14 54.6 0.1 1.6e-09 37.8 0.0 2.2 2 0 0 2 2 2 2 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 ORX45913.1 - 0.00013 21.8 0.2 0.00023 20.9 0.2 1.3 1 0 0 1 1 1 1 Periplasmic binding protein B12-binding PF02310.19 ORX45913.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 B12 binding domain Sulfate_transp PF00916.20 ORX45914.1 - 9.6e-107 357.0 18.2 1.2e-106 356.7 18.2 1.1 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 ORX45914.1 - 0.0023 18.3 7.0 0.0023 18.3 7.0 3.9 4 1 0 4 4 4 1 Molybdate transporter of MFS superfamily FAM199X PF15814.5 ORX45915.1 - 2.8 6.9 11.5 3.3 6.7 11.5 1.2 1 0 0 1 1 1 0 Protein family FAM199X Rsm22 PF09243.10 ORX45916.1 - 4.7e-74 249.1 0.0 5.8e-74 248.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_25 PF13649.6 ORX45916.1 - 1e-05 26.2 0.0 3.1e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX45916.1 - 0.00025 20.9 0.0 0.00039 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX45916.1 - 0.00044 20.1 0.0 0.0013 18.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX45916.1 - 0.0038 17.9 0.0 0.0089 16.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX45916.1 - 0.022 15.4 0.0 0.047 14.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain 3HCDH_RFF PF18321.1 ORX45916.1 - 0.095 13.2 0.0 27 5.3 0.0 2.4 2 0 0 2 2 2 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain Self-incomp_S1 PF05938.11 ORX45916.1 - 0.11 13.0 0.4 0.21 12.1 0.4 1.4 1 0 0 1 1 1 0 Plant self-incompatibility protein S1 UQ_con PF00179.26 ORX45917.1 - 5.3e-19 68.3 0.2 6.5e-19 68.0 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 ORX45917.1 - 0.0025 17.6 0.4 0.0069 16.2 0.1 1.8 2 0 0 2 2 2 1 UEV domain SirA PF10747.9 ORX45917.1 - 0.0056 17.0 0.1 0.0076 16.6 0.1 1.1 1 0 0 1 1 1 1 Sporulation inhibitor of replication protein SirA Ribosomal_L6 PF00347.23 ORX45918.1 - 2.3e-30 105.1 4.4 1.1e-18 67.7 2.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Herpes_U34 PF04541.13 ORX45918.1 - 0.012 14.9 0.2 0.016 14.4 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus virion protein U34 CDC37_N PF03234.14 ORX45919.1 - 5.9e-37 127.5 15.4 1.7e-36 126.0 2.7 2.7 2 0 0 2 2 2 2 Cdc37 N terminal kinase binding CDC37_M PF08565.11 ORX45919.1 - 5.7e-30 103.7 0.2 5.7e-30 103.7 0.2 2.3 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 ORX45919.1 - 2.1e-12 47.0 0.0 2.1e-12 47.0 0.0 3.0 4 1 1 5 5 5 1 Cdc37 C terminal domain TMEM164 PF14808.6 ORX46030.1 - 1.3e-22 80.4 8.1 1.5e-22 80.2 8.1 1.0 1 0 0 1 1 1 1 TMEM164 family ERCC4 PF02732.15 ORX46032.1 - 1.6e-26 93.4 2.5 2.7e-26 92.6 2.5 1.4 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 ORX46032.1 - 0.004 17.5 0.0 0.0086 16.4 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain MutL PF13941.6 ORX46032.1 - 0.023 13.3 0.0 0.15 10.7 0.0 1.9 2 0 0 2 2 2 0 MutL protein HHH_5 PF14520.6 ORX46032.1 - 0.13 12.9 0.0 15 6.2 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain adh_short PF00106.25 ORX46033.1 - 8e-49 165.7 0.8 1e-48 165.4 0.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX46033.1 - 4.9e-40 137.5 0.5 6e-40 137.2 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX46033.1 - 1.4e-07 31.6 0.3 2.4e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 KR domain Bmp PF02608.14 ORX46033.1 - 0.021 13.8 0.1 0.034 13.1 0.1 1.2 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like Epimerase PF01370.21 ORX46033.1 - 0.072 12.5 0.6 0.23 10.9 0.6 1.8 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ORX46034.1 - 4e-43 147.2 0.1 6.2e-43 146.5 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX46034.1 - 5.6e-40 137.4 0.1 7.6e-40 136.9 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX46034.1 - 5.6e-06 26.4 0.1 1.3e-05 25.1 0.1 1.6 2 0 0 2 2 2 1 KR domain AdoHcyase_NAD PF00670.21 ORX46034.1 - 0.0022 18.1 3.1 0.13 12.4 0.3 3.1 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Epimerase PF01370.21 ORX46034.1 - 0.0086 15.6 0.1 0.013 15.0 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Cys_Met_Meta_PP PF01053.20 ORX46035.1 - 3.4e-157 522.9 0.3 3.8e-157 522.7 0.3 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX46035.1 - 6.1e-06 25.6 0.2 1.1e-05 24.8 0.2 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ORX46035.1 - 1.7e-05 23.9 0.2 3.3e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ORX46035.1 - 0.00035 20.0 0.4 0.00085 18.7 0.5 1.7 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ORX46035.1 - 0.048 12.9 0.4 0.12 11.7 0.4 1.8 1 1 0 1 1 1 0 Beta-eliminating lyase AidB_N PF18158.1 ORX46036.1 - 2.9e-25 89.0 0.0 5.8e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_1 PF00441.24 ORX46036.1 - 2.8e-17 63.3 1.6 5.9e-17 62.3 0.0 2.3 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX46036.1 - 9.5e-14 51.4 0.0 2e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX46036.1 - 0.0024 18.2 0.9 0.22 11.8 0.0 2.7 2 1 1 3 3 3 1 Acyl-CoA dehydrogenase, C-terminal domain Get5_C PF18514.1 ORX46036.1 - 0.17 11.6 0.5 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 Get5 C-terminal domain Snf7 PF03357.21 ORX46037.1 - 5.3e-11 42.4 21.1 8.9e-11 41.7 20.9 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 ORX46037.1 - 0.026 14.5 4.0 0.044 13.7 4.0 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DMSP_lyase PF16867.5 ORX46037.1 - 0.035 13.7 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase Snf7 PF03357.21 ORX46038.1 - 1.2e-24 86.8 25.7 1.2e-24 86.8 25.7 1.4 1 1 0 1 1 1 1 Snf7 TetR_C_29 PF17938.1 ORX46038.1 - 0.027 14.5 0.5 0.046 13.8 0.5 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Myb_DNA-bind_7 PF15963.5 ORX46038.1 - 0.13 12.1 3.6 0.52 10.2 2.8 2.4 2 1 0 2 2 2 0 Myb DNA-binding like T3SS_needle_E PF08988.10 ORX46038.1 - 0.37 11.0 7.1 3.7 7.8 0.0 3.3 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle Latarcin PF10279.9 ORX46038.1 - 1.7 9.1 9.3 0.86 10.0 3.3 3.1 1 1 1 2 2 2 0 Latarcin precursor GAT PF03127.14 ORX46038.1 - 8.3 6.8 13.8 0.46 10.8 0.2 3.4 4 0 0 4 4 4 0 GAT domain PDCD2_C PF04194.13 ORX46039.1 - 4e-42 144.3 6.0 1.5e-40 139.1 0.1 3.0 3 0 0 3 3 3 2 Programmed cell death protein 2, C-terminal putative domain Keratin_2_head PF16208.5 ORX46039.1 - 0.009 16.2 7.8 0.009 16.2 7.8 1.6 2 0 0 2 2 2 1 Keratin type II head Peptidase_S49_N PF08496.10 ORX46039.1 - 0.59 10.2 3.0 1 9.4 3.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal zf-ZPR1 PF03367.13 ORX46041.1 - 1.9e-115 382.1 0.1 3.6e-57 192.7 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zf-RRPl_C4 PF17026.5 ORX46041.1 - 0.0065 16.6 1.1 0.98 9.6 0.1 2.3 2 0 0 2 2 2 1 Putative ribonucleoprotein zinc-finger pf C4 type HypA PF01155.19 ORX46041.1 - 0.0093 16.0 1.2 4.8 7.2 0.1 2.5 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 ORX46041.1 - 0.027 14.4 2.0 2.9 8.0 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbons UPF0547 PF10571.9 ORX46041.1 - 0.082 13.0 5.8 1.2 9.3 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0547 DUF5530 PF17670.1 ORX46041.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5530) DUF2387 PF09526.10 ORX46041.1 - 0.12 12.5 1.0 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) DUF983 PF06170.12 ORX46041.1 - 0.19 12.2 1.3 51 4.4 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF983) zf-ribbon_3 PF13248.6 ORX46041.1 - 0.28 10.6 10.6 1.6 8.3 0.6 3.5 3 0 0 3 3 3 0 zinc-ribbon domain DZR PF12773.7 ORX46041.1 - 1.3 9.1 11.1 1.4 9.0 1.1 3.1 2 2 0 2 2 2 0 Double zinc ribbon Lar_restr_allev PF14354.6 ORX46041.1 - 3.1 8.3 5.8 47 4.5 0.1 3.1 3 1 1 4 4 4 0 Restriction alleviation protein Lar YqeY PF09424.10 ORX46042.1 - 4.6e-35 120.8 3.9 5.4e-35 120.6 3.9 1.0 1 0 0 1 1 1 1 Yqey-like protein Methyltransf_11 PF08241.12 ORX46043.1 - 2.3e-12 47.4 0.0 6.4e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX46043.1 - 8.2e-10 39.3 0.0 1.8e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX46043.1 - 0.00013 21.4 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX46043.1 - 0.0003 20.6 0.0 0.0016 18.3 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX46043.1 - 0.00037 20.4 0.0 0.0006 19.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX46043.1 - 0.0048 17.6 0.0 0.017 15.9 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX46043.1 - 0.015 15.2 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase RabGAP-TBC PF00566.18 ORX46044.1 - 5.5e-43 147.1 1.6 1.1e-42 146.2 1.6 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PAP2 PF01569.21 ORX46045.1 - 7.7e-30 103.4 0.5 7.7e-30 103.4 0.5 1.9 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ORX46045.1 - 0.0076 16.0 2.1 0.16 11.6 1.7 2.4 1 1 0 1 1 1 1 PAP2 superfamily Virul_fac_BrkB PF03631.15 ORX46045.1 - 0.047 13.3 3.8 0.28 10.8 0.5 2.2 2 0 0 2 2 2 0 Virulence factor BrkB DUF5510 PF17629.2 ORX46045.1 - 0.05 13.5 0.3 0.22 11.5 0.3 2.2 1 1 0 1 1 1 0 Family of unknown function (DUF5510) DUF2207 PF09972.9 ORX46045.1 - 0.24 10.1 1.1 0.42 9.3 1.1 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1461 PF07314.11 ORX46045.1 - 0.26 11.2 1.8 0.94 9.4 0.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1461) DUF1700 PF08006.11 ORX46045.1 - 0.62 9.6 3.3 1.2 8.7 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Peptidase_C14 PF00656.22 ORX46047.1 - 3.2e-62 210.7 0.0 4.1e-62 210.3 0.0 1.1 1 0 0 1 1 1 1 Caspase domain AMP-binding PF00501.28 ORX46049.1 - 2.4e-50 171.4 0.0 5.3e-50 170.2 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX46049.1 - 2.4e-10 41.2 0.0 1.7e-07 32.1 0.0 3.3 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain PP-binding PF00550.25 ORX46049.1 - 2.8e-08 34.0 0.0 8.5e-08 32.4 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep PF00132.24 ORX46049.1 - 1.6e-07 30.8 4.1 0.013 15.2 0.0 5.7 6 0 0 6 6 6 2 Bacterial transferase hexapeptide (six repeats) DUF2087 PF09860.9 ORX46049.1 - 0.038 14.1 0.1 0.091 12.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2087) Hexapep_2 PF14602.6 ORX46049.1 - 0.9 9.4 8.8 3.1 7.7 0.0 4.5 4 1 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase zf-RVT PF13966.6 ORX46050.1 - 2.1e-06 28.3 0.2 4e-06 27.4 0.2 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase OrfB_Zn_ribbon PF07282.11 ORX46050.1 - 0.087 12.8 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Chromo PF00385.24 ORX46052.1 - 7.9e-12 44.9 1.6 1.9e-11 43.7 1.6 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 ORX46052.1 - 0.078 12.9 1.5 0.083 12.8 0.2 1.8 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain PolyA_pol_arg_C PF12626.7 ORX46052.1 - 0.18 11.8 2.5 0.23 11.5 2.5 1.2 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus DASH_Duo1 PF08651.10 ORX46053.1 - 5.3e-29 99.8 14.0 0.032 14.0 0.1 12.0 4 4 8 12 12 12 8 DASH complex subunit Duo1 DUF948 PF06103.11 ORX46053.1 - 9.5e-25 86.7 20.1 0.018 15.3 0.4 11.2 4 4 3 7 7 7 7 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ORX46053.1 - 5.2e-14 52.4 19.3 0.0065 16.5 0.5 6.0 4 2 2 6 6 6 5 Laminin Domain II MscS_porin PF12795.7 ORX46053.1 - 4.8e-11 42.7 0.0 0.17 11.4 0.0 5.1 3 2 2 5 5 5 4 Mechanosensitive ion channel porin domain Fusion_gly PF00523.18 ORX46053.1 - 1.7e-10 39.8 15.6 0.0047 15.2 0.7 5.4 4 1 2 6 6 6 6 Fusion glycoprotein F0 Spc7 PF08317.11 ORX46053.1 - 4.3e-08 32.4 0.0 3.2 6.5 0.0 4.8 3 2 2 5 5 5 3 Spc7 kinetochore protein IFT57 PF10498.9 ORX46053.1 - 1.1e-07 31.2 0.0 0.081 11.9 0.0 4.3 3 2 1 4 4 4 2 Intra-flagellar transport protein 57 COG5 PF10392.9 ORX46053.1 - 1.6e-06 28.3 2.0 23 5.1 0.0 7.3 5 4 3 8 8 7 0 Golgi transport complex subunit 5 HemX PF04375.14 ORX46053.1 - 1.7e-06 27.5 2.8 4.7 6.4 0.0 4.9 1 1 4 5 5 5 2 HemX, putative uroporphyrinogen-III C-methyltransferase Laminin_I PF06008.14 ORX46053.1 - 4.9e-06 26.4 9.5 0.073 12.8 0.6 5.5 4 2 1 5 5 5 2 Laminin Domain I TelA PF05816.11 ORX46053.1 - 1.3e-05 24.5 0.2 0.21 10.6 0.0 4.1 3 2 0 4 4 4 1 Toxic anion resistance protein (TelA) Paramyx_P_V_C PF03210.13 ORX46053.1 - 5.9e-05 22.9 12.5 17 5.1 0.1 7.9 4 4 2 6 6 6 0 Paramyxovirus P/V phosphoprotein C-terminal DNA_photolyase PF00875.18 ORX46053.1 - 0.00058 19.9 3.0 46 4.0 0.0 6.8 1 1 2 5 5 5 0 DNA photolyase YkyA PF10368.9 ORX46053.1 - 0.00065 19.4 0.0 80 2.8 0.0 5.6 5 2 0 6 6 6 0 Putative cell-wall binding lipoprotein MT PF12777.7 ORX46053.1 - 0.00072 18.7 23.6 1.7 7.6 1.4 6.5 3 2 3 7 7 7 3 Microtubule-binding stalk of dynein motor BRCT_assoc PF12820.7 ORX46053.1 - 0.0013 18.5 13.7 0.99 9.2 0.2 7.2 3 3 3 7 7 7 1 Serine-rich domain associated with BRCT Val_tRNA-synt_C PF10458.9 ORX46053.1 - 0.0015 18.7 35.1 58 4.1 0.1 12.9 5 4 8 13 13 13 0 Valyl tRNA synthetase tRNA binding arm ATG16 PF08614.11 ORX46053.1 - 0.0026 18.0 0.0 5.5 7.2 0.0 3.1 3 0 0 3 3 3 1 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 ORX46053.1 - 0.0091 14.7 3.0 1 7.9 0.1 2.7 3 0 0 3 3 3 2 AAA domain EzrA PF06160.12 ORX46053.1 - 0.013 13.7 0.0 1.3 7.1 0.0 3.4 4 0 0 4 4 4 0 Septation ring formation regulator, EzrA DUF3829 PF12889.7 ORX46053.1 - 0.056 12.9 2.2 9.3 5.6 0.1 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF3829) UL2 PF08196.11 ORX46053.1 - 0.062 13.3 0.0 17 5.4 0.0 2.4 2 0 0 2 2 2 0 UL2 protein BLOC1S3 PF15753.5 ORX46053.1 - 0.16 12.1 14.1 22 5.1 0.3 5.7 4 1 2 6 6 6 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Vps5 PF09325.10 ORX46053.1 - 0.2 11.2 18.4 14 5.2 2.5 6.1 4 2 1 5 5 5 0 Vps5 C terminal like Tropomyosin PF00261.20 ORX46053.1 - 0.27 10.6 0.0 26 4.1 0.0 3.4 4 1 0 4 4 4 0 Tropomyosin Phage_GPL PF05926.11 ORX46053.1 - 1.1 9.3 15.6 12 5.9 0.1 7.7 3 3 6 9 9 9 0 Phage head completion protein (GPL) PhyH PF05721.13 ORX46054.1 - 3e-11 44.0 0.2 4.4e-11 43.4 0.2 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) HLH PF00010.26 ORX46055.1 - 1.5e-10 40.9 0.2 2.8e-10 40.0 0.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Mob1_phocein PF03637.17 ORX46056.1 - 7.6e-34 117.2 0.7 1e-33 116.7 0.7 1.1 1 0 0 1 1 1 1 Mob1/phocein family Glyco_transf_49 PF13896.6 ORX46057.1 - 2.9e-58 197.8 5.8 4.2e-49 167.7 2.3 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_tranf_2_4 PF13704.6 ORX46057.1 - 0.0026 18.3 0.1 0.0077 16.7 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 Melibiase PF02065.18 ORX46058.1 - 6e-111 370.7 0.0 7.7e-111 370.4 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 ORX46058.1 - 3.9e-41 141.3 0.0 5.1e-41 140.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_31 PF01055.26 ORX46058.1 - 4.2e-07 29.5 0.1 6e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Glyco_hydro_36C PF16874.5 ORX46058.1 - 5.1e-07 30.1 0.0 1.3e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain Melibiase_2 PF16499.5 ORX46058.1 - 0.00027 20.2 0.0 0.00046 19.4 0.0 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Complex1_LYR PF05347.15 ORX46059.1 - 2.5e-09 37.0 7.2 4.2e-09 36.3 7.2 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX46059.1 - 0.015 16.0 1.9 0.043 14.6 1.9 1.8 1 0 0 1 1 1 0 Complex1_LYR-like PALP PF00291.25 ORX46060.1 - 3.2e-63 213.9 0.0 3.8e-63 213.6 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme pPIWI_RE_REase PF18154.1 ORX46060.1 - 0.0019 18.2 0.0 0.0033 17.4 0.0 1.4 1 0 0 1 1 1 1 REase associating with pPIWI_RE GFO_IDH_MocA PF01408.22 ORX46061.1 - 1.6e-27 96.7 0.1 7.4e-26 91.3 0.2 2.6 3 0 0 3 3 3 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ORX46061.1 - 1.2e-14 54.3 0.0 2.3e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Semialdhyde_dh PF01118.24 ORX46061.1 - 1.7e-05 25.3 0.1 3.1e-05 24.4 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_3 PF03447.16 ORX46061.1 - 5.9e-05 23.7 0.1 0.00011 22.8 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CoA_binding PF02629.19 ORX46061.1 - 0.0058 17.3 0.3 0.011 16.4 0.3 1.4 1 0 0 1 1 1 1 CoA binding domain DapB_N PF01113.20 ORX46061.1 - 0.032 14.3 0.7 0.056 13.6 0.7 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Autoind_bind PF03472.15 ORX46061.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Autoinducer binding domain Sel1 PF08238.12 ORX46062.1 - 1.1e-111 362.7 58.5 1.2e-10 41.7 1.0 12.6 13 0 0 13 13 13 12 Sel1 repeat TPR_6 PF13174.6 ORX46062.1 - 0.00015 22.2 4.2 0.89 10.3 0.1 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat NEMP PF10225.9 ORX46062.1 - 0.024 14.3 1.2 7 6.2 0.0 3.7 4 1 1 5 5 5 0 NEMP family Hist_deacetyl PF00850.19 ORX46062.1 - 0.54 9.7 4.4 8.8 5.7 0.0 3.3 3 1 0 3 3 3 0 Histone deacetylase domain Thioredoxin PF00085.20 ORX46064.1 - 4.1e-28 97.4 0.2 4.8e-28 97.2 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX46064.1 - 7.6e-07 29.6 0.2 1.3e-05 25.6 0.2 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ORX46064.1 - 4.8e-06 26.4 0.0 5.9e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin AhpC-TSA PF00578.21 ORX46064.1 - 1.5e-05 24.9 0.0 1.8e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 ORX46064.1 - 0.00011 22.3 0.2 0.00031 20.9 0.1 1.8 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_8 PF13905.6 ORX46064.1 - 0.00022 21.5 0.0 0.00042 20.6 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like End_N_terminal PF12218.8 ORX46064.1 - 0.046 13.4 0.0 0.07 12.8 0.0 1.4 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase OST3_OST6 PF04756.13 ORX46064.1 - 0.13 11.5 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family FAD_binding_1 PF00667.20 ORX46065.1 - 1.8e-44 152.0 0.1 3.2e-44 151.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX46065.1 - 2.3e-34 118.6 0.0 4.9e-34 117.6 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX46065.1 - 3e-19 69.7 0.0 4.4e-18 65.9 0.0 2.8 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain SPRY PF00622.28 ORX46066.1 - 7.3e-24 84.2 0.6 9.7e-24 83.8 0.6 1.2 1 0 0 1 1 1 1 SPRY domain CLTH PF10607.9 ORX46067.1 - 8.1e-16 58.2 0.0 1e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain EBP PF05241.12 ORX46068.1 - 0.013 15.0 5.1 0.06 12.8 5.1 2.0 1 1 0 1 1 1 0 Emopamil binding protein Ribosomal_S9 PF00380.19 ORX46069.1 - 1.2e-30 106.5 0.2 1.3e-30 106.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF2102 PF09875.9 ORX46069.1 - 0.079 12.7 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2102) LRR_4 PF12799.7 ORX46070.1 - 0.00011 22.4 3.3 0.04 14.4 1.0 2.6 1 1 1 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX46070.1 - 0.00065 19.4 4.4 0.31 10.8 0.2 2.3 1 1 1 2 2 2 2 Leucine rich repeat DUF1644 PF07800.12 ORX46071.1 - 0.0025 17.9 1.6 0.0025 17.9 1.6 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1644) DUF4298 PF14131.6 ORX46071.1 - 0.24 11.4 0.5 0.66 10.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) NifQ PF04891.12 ORX46071.1 - 2.5 8.4 8.5 2.4 8.5 1.8 2.5 2 0 0 2 2 2 0 NifQ zf-Mss51 PF13824.6 ORX46073.1 - 0.098 12.8 0.8 23 5.2 0.0 3.0 3 0 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Phage_tail_APC PF16778.5 ORX46073.1 - 0.12 12.3 0.2 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Phage tail assembly chaperone protein zf-CCHC_6 PF15288.6 ORX46073.1 - 0.23 11.3 10.1 2.3 8.1 2.0 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCCH_6 PF18585.1 ORX46073.1 - 0.53 10.2 7.3 3.1 7.7 0.2 2.7 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 DZR PF12773.7 ORX46073.1 - 0.88 9.6 6.1 11 6.1 0.7 2.4 2 0 0 2 2 2 0 Double zinc ribbon zf-CCHC_4 PF14392.6 ORX46073.1 - 5.2 6.9 5.2 0.68 9.7 0.3 2.0 2 0 0 2 2 2 0 Zinc knuckle LRR_6 PF13516.6 ORX46078.1 - 3.9e-12 45.2 25.6 0.012 15.6 1.2 10.6 11 0 0 11 11 11 5 Leucine Rich repeat LRR_1 PF00560.33 ORX46078.1 - 7.5e-05 22.8 19.4 23 6.0 0.2 8.6 9 0 0 9 9 9 3 Leucine Rich Repeat LRR_4 PF12799.7 ORX46078.1 - 0.0046 17.3 29.0 0.55 10.7 1.4 7.5 5 3 3 8 8 8 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX46078.1 - 0.61 9.9 21.8 1.5 8.6 0.1 7.2 5 4 1 6 6 6 0 Leucine rich repeat IPPT PF01715.17 ORX46079.1 - 9.8e-66 221.8 0.1 1.4e-65 221.3 0.1 1.2 1 0 0 1 1 1 1 IPP transferase AAA_18 PF13238.6 ORX46079.1 - 0.00026 21.6 0.2 0.033 14.7 0.2 2.7 1 1 0 1 1 1 1 AAA domain IPT PF01745.16 ORX46079.1 - 0.0014 18.1 0.1 0.0029 17.0 0.1 1.5 1 0 0 1 1 1 1 Isopentenyl transferase AAA_33 PF13671.6 ORX46079.1 - 0.0042 17.3 0.3 0.033 14.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain Phosphodiest PF01663.22 ORX46080.1 - 7.9e-13 48.7 0.3 3.9e-12 46.4 0.1 1.8 1 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ORX46080.1 - 0.0032 16.9 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ORX46080.1 - 0.0094 15.4 0.0 0.029 13.8 0.0 1.8 1 1 1 2 2 2 1 Sulfatase ATG22 PF11700.8 ORX46081.1 - 0.15 10.6 0.0 0.19 10.3 0.0 1.0 1 0 0 1 1 1 0 Vacuole effluxer Atg22 like OrsD PF12013.8 ORX46082.1 - 4e-11 43.4 3.7 1.2e-10 41.9 3.7 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D Pribosyltran PF00156.27 ORX46082.1 - 0.055 13.0 0.0 0.096 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase domain zf-C2H2_12 PF18658.1 ORX46082.1 - 0.28 10.8 2.5 0.71 9.5 2.5 1.7 1 0 0 1 1 1 0 Zinc-finger C2H2-type Nicastrin PF05450.15 ORX46083.1 - 0.03 13.8 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Nicastrin Peptidase_S28 PF05577.12 ORX46085.1 - 1.2e-64 218.7 1.7 2.5e-64 217.7 1.7 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 DCP1 PF06058.13 ORX46086.1 - 0.14 12.1 0.1 19 5.2 0.0 2.1 1 1 1 2 2 2 0 Dcp1-like decapping family Peptidase_S28 PF05577.12 ORX46089.1 - 1.4e-67 228.4 1.0 1.9e-67 228.0 1.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Abhydrolase_1 PF00561.20 ORX46089.1 - 0.0031 17.2 1.7 0.0065 16.1 0.1 2.3 2 1 0 2 2 2 1 alpha/beta hydrolase fold ubiquitin PF00240.23 ORX46090.1 - 0.0008 19.1 0.3 0.041 13.6 0.1 2.2 2 0 0 2 2 2 2 Ubiquitin family Ubiquitin_2 PF14560.6 ORX46090.1 - 0.0046 17.4 0.2 0.0046 17.4 0.2 2.0 2 1 0 2 2 2 1 Ubiquitin-like domain WYL_2 PF10902.8 ORX46090.1 - 0.12 12.8 0.4 0.41 11.1 0.4 2.1 1 1 0 1 1 1 0 WYL_2, Sm-like SH3 beta-barrel fold SPT_ssu-like PF11779.8 ORX46091.1 - 7.8e-19 67.0 4.1 8.7e-19 66.9 4.1 1.1 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DUF1400 PF07176.11 ORX46091.1 - 0.057 13.7 0.1 0.058 13.7 0.1 1.0 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) Ribosomal_L7Ae PF01248.26 ORX46092.1 - 2.1e-27 94.7 0.9 2.8e-27 94.3 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family HD_2 PF12917.7 ORX46092.1 - 0.032 14.0 0.4 0.043 13.6 0.4 1.2 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme DHOase PF12890.7 ORX46092.1 - 0.075 13.0 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Dihydro-orotase-like PELOTA_1 PF15608.6 ORX46092.1 - 0.13 12.1 0.4 0.27 11.1 0.2 1.6 1 1 0 1 1 1 0 PELOTA RNA binding domain Ribosomal_L23eN PF03939.13 ORX46093.1 - 5.2e-21 74.6 9.2 5.2e-21 74.6 9.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 ORX46093.1 - 3.8e-16 59.2 8.7 7.6e-16 58.3 3.4 2.8 2 1 0 2 2 2 1 Ribosomal protein L23 DUF4291 PF14124.6 ORX46094.1 - 5.5e-47 160.0 0.3 1.3e-46 158.7 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4291) PI3_PI4_kinase PF00454.27 ORX46095.1 - 1.2e-39 136.6 0.0 1.4e-37 129.9 0.0 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ORX46095.1 - 1.5e-23 83.2 0.0 4.6e-23 81.6 0.0 1.9 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Mu-like_Pro PF10123.9 ORX46095.1 - 0.12 11.9 1.0 0.27 10.8 1.0 1.5 1 0 0 1 1 1 0 Mu-like prophage I protein Methyltransf_28 PF02636.17 ORX46096.1 - 3.6e-38 131.7 0.0 5.1e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase RrnaAD PF00398.20 ORX46096.1 - 0.0097 15.0 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PRMT5 PF05185.16 ORX46096.1 - 0.024 14.5 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 PRMT5 arginine-N-methyltransferase Methyltransf_12 PF08242.12 ORX46096.1 - 0.052 14.3 0.0 0.14 13.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Redoxin PF08534.10 ORX46097.1 - 9.7e-36 122.7 0.0 1.1e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ORX46097.1 - 1.1e-08 35.0 0.0 1.3e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Peptidase_S28 PF05577.12 ORX46098.1 - 2.8e-52 178.0 0.1 3.5e-52 177.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 ORX46098.1 - 0.0071 15.8 0.2 0.025 14.1 0.2 1.8 1 1 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ORX46098.1 - 0.068 12.8 0.3 0.12 12.0 0.2 1.4 1 1 0 1 1 1 0 Putative esterase STAG PF08514.11 ORX46099.1 - 3.9e-34 116.9 1.5 3.9e-34 116.9 1.5 3.2 3 0 0 3 3 3 1 STAG domain RTP1_C1 PF10363.9 ORX46099.1 - 0.051 13.8 0.3 9.7 6.4 0.1 3.9 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 SecIII_SopE_N PF05364.14 ORX46099.1 - 0.062 13.4 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Salmonella type III secretion SopE effector N-terminus Myb_DNA-binding PF00249.31 ORX46100.1 - 1.5e-17 63.5 0.5 1.4e-06 28.4 0.0 3.6 3 1 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX46100.1 - 4.2e-15 55.7 0.3 1.4e-08 34.8 0.1 3.1 2 1 1 3 3 3 2 Myb-like DNA-binding domain DUF4096 PF13340.6 ORX46100.1 - 0.055 13.7 0.2 0.22 11.8 0.0 2.0 2 0 0 2 2 2 0 Putative transposase of IS4/5 family (DUF4096) Aminotran_1_2 PF00155.21 ORX46101.1 - 1.9e-41 142.4 0.0 3.7e-41 141.5 0.0 1.4 2 0 0 2 2 2 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX46101.1 - 0.018 14.3 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Sld7_C PF18596.1 ORX46102.1 - 0.0015 18.7 0.6 0.0034 17.5 0.6 1.6 1 0 0 1 1 1 1 Sld7 C-terminal domain Hepatitis_core PF00906.20 ORX46102.1 - 0.0033 17.0 0.1 0.0044 16.6 0.1 1.2 1 0 0 1 1 1 1 Hepatitis core antigen Zn_clus PF00172.18 ORX46103.1 - 4.4e-09 36.3 13.6 9.7e-09 35.2 13.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Promethin PF16015.5 ORX46104.1 - 2.5e-06 27.4 17.7 2.8e-06 27.2 17.7 1.2 1 0 0 1 1 1 1 Promethin SUR7 PF06687.12 ORX46104.1 - 8 6.0 13.1 11 5.6 13.1 1.2 1 0 0 1 1 1 0 SUR7/PalI family F-actin_cap_A PF01267.17 ORX46105.1 - 7.1e-22 78.1 0.1 7.6e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF512 PF04459.12 ORX46105.1 - 0.069 12.4 0.0 0.074 12.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF512) F-actin_cap_A PF01267.17 ORX46106.1 - 1.2e-70 238.0 0.6 1.4e-70 237.8 0.6 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit DUF370 PF04025.12 ORX46107.1 - 0.021 14.9 0.1 0.054 13.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF370) DUF2569 PF10754.9 ORX46107.1 - 0.55 10.7 7.9 0.77 10.2 2.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) DHFR_1 PF00186.19 ORX46109.1 - 1.6e-31 109.2 0.0 1.1e-22 80.4 0.0 2.1 2 0 0 2 2 2 2 Dihydrofolate reductase Pro_isomerase PF00160.21 ORX46110.1 - 2e-17 63.9 0.0 2.7e-17 63.5 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UDPGT PF00201.18 ORX46111.1 - 1.7e-25 89.8 2.2 4.5e-25 88.4 0.1 2.4 2 1 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_4 PF13439.6 ORX46111.1 - 0.0012 18.9 4.3 0.0035 17.4 0.0 2.8 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Glyco_tran_28_C PF04101.16 ORX46111.1 - 0.017 15.1 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.6 ORX46111.1 - 0.21 12.0 4.4 0.32 11.4 0.0 3.1 2 2 2 4 4 4 0 Glycosyl transferase 4-like domain Tcp11 PF05794.13 ORX46112.1 - 1.4e-67 228.7 4.4 1.4e-67 228.7 4.4 1.7 2 0 0 2 2 2 1 T-complex protein 11 PfkB PF00294.24 ORX46113.1 - 1.4e-30 106.6 0.0 1.7e-30 106.4 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase ACT_3 PF10000.9 ORX46113.1 - 0.18 11.8 0.0 15 5.6 0.0 2.3 2 0 0 2 2 2 0 ACT domain zf-C2H2_3rep PF18868.1 ORX46114.1 - 0.0022 18.7 2.9 0.051 14.2 0.2 2.3 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats MIEAP PF16026.5 ORX46114.1 - 0.02 15.1 0.6 0.027 14.7 0.6 1.2 1 0 0 1 1 1 0 Mitochondria-eating protein CpXC PF14353.6 ORX46114.1 - 0.027 14.5 3.0 1.5 8.9 0.1 2.3 1 1 1 2 2 2 0 CpXC protein Condensin2nSMC PF12422.8 ORX46114.1 - 0.094 12.9 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit zf-H2C2_2 PF13465.6 ORX46114.1 - 0.11 12.9 1.6 0.11 12.9 1.6 5.6 5 1 0 5 5 5 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX46114.1 - 0.15 12.9 23.3 0.38 11.7 0.9 4.7 4 0 0 4 4 4 0 C2H2-type zinc finger DUF629 PF04780.12 ORX46114.1 - 0.23 9.9 6.0 0.1 11.1 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_9 PF16293.5 ORX46114.1 - 1.1 9.2 4.7 0.77 9.7 0.2 2.7 3 1 0 3 3 3 0 C2H2 type zinc-finger (1 copy) HNH_5 PF14279.6 ORX46114.1 - 1.4 8.8 7.3 10 6.1 1.2 2.6 2 0 0 2 2 2 0 HNH endonuclease Ogr_Delta PF04606.12 ORX46114.1 - 3.1 7.8 9.3 0.27 11.2 1.1 2.6 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger PIP5K PF01504.18 ORX46115.1 - 5.6e-99 330.8 0.0 7.5e-99 330.4 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase FMN_red PF03358.15 ORX46116.1 - 3.5e-10 39.8 1.2 6.2e-10 39.0 0.0 1.9 2 0 0 2 2 2 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX46116.1 - 6e-05 22.8 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Flavodoxin-like fold Prim_Zn_Ribbon PF08273.12 ORX46116.1 - 0.11 12.8 0.5 3.3 8.1 0.1 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Peroxin-13_N PF04088.13 ORX46117.1 - 1.4e-50 171.3 1.2 2e-50 170.9 1.2 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 ORX46117.1 - 1.2e-13 50.5 0.0 2.1e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX46117.1 - 7.2e-13 48.0 0.0 1.5e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX46117.1 - 4.4e-10 39.3 0.0 7.7e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pex2_Pex12 PF04757.14 ORX46117.1 - 0.057 13.0 0.0 0.08 12.5 0.0 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region DUF3104 PF11302.8 ORX46117.1 - 0.13 12.0 0.0 0.36 10.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) ABA_GPCR PF12430.8 ORX46117.1 - 0.13 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor adh_short_C2 PF13561.6 ORX46118.1 - 4.5e-49 167.1 0.3 5.7e-49 166.8 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX46118.1 - 1.4e-43 148.6 0.1 2.1e-43 148.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX46118.1 - 2.5e-07 30.8 0.1 5.2e-07 29.7 0.0 1.5 2 0 0 2 2 2 1 KR domain DUF1776 PF08643.10 ORX46118.1 - 0.0012 18.3 0.0 0.0014 18.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) TFIIB PF00382.19 ORX46118.1 - 0.013 15.6 0.6 1.4 9.1 0.0 2.9 3 0 0 3 3 3 0 Transcription factor TFIIB repeat Shikimate_DH PF01488.20 ORX46118.1 - 0.024 14.7 0.3 0.069 13.2 0.1 1.9 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ORX46118.1 - 0.025 15.0 3.1 0.1 13.1 0.3 2.8 2 1 0 2 2 2 0 Putative NAD(P)-binding Carboxyl_trans PF01039.22 ORX46119.1 - 3.3e-108 362.4 1.1 1.8e-62 211.6 0.0 2.0 1 1 1 2 2 2 2 Carboxyl transferase domain ThrE PF06738.12 ORX46120.1 - 4.3e-49 167.1 25.0 2e-46 158.4 6.0 2.1 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX46120.1 - 5.5e-05 23.3 10.0 5.5e-05 23.3 10.0 2.5 2 1 0 2 2 2 2 Threonine/Serine exporter, ThrE Methyltransf_15 PF09445.10 ORX46121.1 - 2.7e-45 153.9 0.1 3.5e-45 153.5 0.1 1.1 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 ORX46121.1 - 8e-09 35.5 0.1 2.2e-08 34.0 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ORX46121.1 - 5.8e-08 32.6 0.0 3e-07 30.3 0.0 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 ORX46121.1 - 7.1e-08 33.1 0.0 2.1e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 ORX46121.1 - 1.1e-05 25.3 0.0 1.6e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein PrmA PF06325.13 ORX46121.1 - 4.1e-05 23.1 0.0 5.8e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ORX46121.1 - 6e-05 22.8 0.0 8.9e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX46121.1 - 0.00011 22.7 0.0 0.00022 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX46121.1 - 0.0061 16.5 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 ORX46121.1 - 0.012 15.1 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 MraW methylase family TRM PF02005.16 ORX46121.1 - 0.024 13.8 0.0 0.03 13.5 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Disulph_isomer PF06491.11 ORX46121.1 - 0.073 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Disulphide isomerase tRNA_U5-meth_tr PF05958.11 ORX46121.1 - 0.15 11.0 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase G6PD_N PF00479.22 ORX46122.1 - 0.026 15.2 0.0 0.027 15.1 0.0 1.1 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase, NAD binding domain XisH PF08814.10 ORX46123.1 - 0.017 15.3 0.0 0.019 15.1 0.0 1.1 1 0 0 1 1 1 0 XisH protein LRR_6 PF13516.6 ORX46124.1 - 9.2e-08 31.6 1.4 3.7 7.9 0.0 6.0 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 ORX46124.1 - 0.0005 20.4 0.0 2.2 8.8 0.0 4.1 4 1 0 4 4 4 2 Leucine Rich repeats (2 copies) Proteasome PF00227.26 ORX46125.1 - 3.7e-38 130.9 0.1 5.5e-38 130.4 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit PT-TG PF14449.6 ORX46125.1 - 0.097 12.6 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Pre-toxin TG Ldh_1_C PF02866.18 ORX46126.1 - 1.6e-48 164.8 0.1 7.7e-48 162.6 0.1 2.0 3 0 0 3 3 3 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ORX46126.1 - 9.2e-47 158.7 0.2 1.7e-46 157.8 0.2 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ORX46126.1 - 1.1e-05 24.7 0.0 1.6e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 ORX46126.1 - 0.0021 18.5 0.9 0.0071 16.8 0.1 2.3 2 1 1 3 3 3 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX46126.1 - 0.01 16.0 0.0 0.026 14.6 0.0 1.7 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Glyco_hydro_4 PF02056.16 ORX46126.1 - 0.014 15.0 1.2 0.65 9.5 0.0 2.5 2 1 1 3 3 3 0 Family 4 glycosyl hydrolase THF_DHG_CYH_C PF02882.19 ORX46126.1 - 0.032 13.6 1.1 0.37 10.1 0.4 2.7 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_10 PF13460.6 ORX46126.1 - 0.038 13.9 0.1 0.059 13.3 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H-binding DUF4574 PF15141.6 ORX46126.1 - 0.12 12.3 0.0 8 6.4 0.0 2.3 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 PfkB PF00294.24 ORX46127.1 - 4.7e-27 95.1 0.0 1.2e-26 93.8 0.0 1.5 1 1 0 1 1 1 1 pfkB family carbohydrate kinase B56 PF01603.20 ORX46128.1 - 1.6e-191 636.8 7.9 2.3e-191 636.3 7.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) TauD PF02668.16 ORX46129.1 - 2e-54 185.2 0.5 2.5e-54 184.9 0.5 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family TauD PF02668.16 ORX46130.1 - 7.9e-61 206.2 1.7 1e-60 205.9 1.7 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family PAPS_reduct PF01507.19 ORX46130.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.6 1 1 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Cation_efflux PF01545.21 ORX46131.1 - 7.1e-31 107.5 8.4 8.9e-31 107.2 8.4 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ORX46131.1 - 3.4e-08 33.5 0.0 1e-07 31.9 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter WD40 PF00400.32 ORX46133.1 - 3.8e-42 141.5 27.6 2.4e-06 28.1 0.1 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX46133.1 - 2.5e-15 56.5 4.6 0.022 15.0 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ORX46133.1 - 2.6e-09 36.8 0.4 5.4e-09 35.8 0.4 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ORX46133.1 - 2.1e-08 33.3 10.5 0.14 10.8 0.1 5.9 3 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX46133.1 - 4.7e-07 29.4 0.0 0.0015 17.9 0.0 3.1 1 1 2 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 ORX46133.1 - 6.3e-05 23.0 0.0 1.7 8.7 0.0 4.8 4 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region F-box PF00646.33 ORX46133.1 - 0.00022 21.0 0.5 0.00046 20.0 0.5 1.6 1 0 0 1 1 1 1 F-box domain PQQ_2 PF13360.6 ORX46133.1 - 0.0012 18.5 2.5 0.11 12.1 1.5 3.0 1 1 1 2 2 2 1 PQQ-like domain Sulfate_transp PF00916.20 ORX46134.1 - 1.2e-75 254.6 19.8 1.6e-75 254.2 19.8 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX46134.1 - 1.2e-25 89.4 0.0 2.4e-25 88.4 0.0 1.5 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ORX46134.1 - 0.07 13.5 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 STAS domain DUF4079 PF13301.6 ORX46134.1 - 1.9 8.7 7.7 0.29 11.3 0.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4079) SNF2_N PF00176.23 ORX46135.1 - 2.8e-54 184.2 0.0 4.4e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ORX46135.1 - 0.0092 16.0 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SAM_KSR1 PF13543.6 ORX46135.1 - 0.11 12.7 4.3 0.23 11.6 4.3 1.5 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 Helicase_C PF00271.31 ORX46136.1 - 2.5e-06 27.8 0.1 9e-06 26.0 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain PLATZ PF04640.14 ORX46136.1 - 0.065 13.9 0.4 0.22 12.2 0.1 2.1 2 0 0 2 2 2 0 PLATZ transcription factor GAS PF13851.6 ORX46136.1 - 0.071 12.5 16.8 0.98 8.7 13.1 2.7 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding UPF0515 PF15135.6 ORX46136.1 - 0.26 10.6 2.4 0.4 10.0 0.0 2.2 2 1 0 2 2 2 0 Uncharacterised protein UPF0515 zf-C3HC4_2 PF13923.6 ORX46136.1 - 0.56 10.1 3.3 0.46 10.4 1.4 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF1539 PF07560.11 ORX46136.1 - 3.7 7.7 5.8 8.9 6.4 0.7 3.4 3 1 1 4 4 4 0 Domain of Unknown Function (DUF1539) DUF5082 PF16888.5 ORX46256.1 - 0.42 10.9 6.0 2.2 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) OrfB_Zn_ribbon PF07282.11 ORX46257.1 - 1.8e-08 34.2 0.7 2.7e-08 33.6 0.7 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain IF4E PF01652.18 ORX46257.1 - 0.014 15.2 0.0 0.018 14.8 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic initiation factor 4E DZR PF12773.7 ORX46257.1 - 0.042 13.9 0.9 0.07 13.2 0.9 1.3 1 0 0 1 1 1 0 Double zinc ribbon TIP49 PF06068.13 ORX46258.1 - 4.7e-172 572.0 0.2 5.7e-172 571.7 0.2 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ORX46258.1 - 6.8e-23 80.6 0.0 1.7e-22 79.3 0.0 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 ORX46258.1 - 3e-10 40.6 1.4 6.6e-06 26.6 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX46258.1 - 3.4e-10 39.9 0.1 1.1e-06 28.5 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX46258.1 - 1.6e-05 25.2 0.0 0.017 15.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ORX46258.1 - 0.00022 21.6 0.4 0.004 17.6 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX46258.1 - 0.00024 21.1 0.0 0.082 12.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ORX46258.1 - 0.0011 18.4 0.1 0.054 12.9 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ORX46258.1 - 0.0023 17.6 0.1 2.1 8.0 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain ResIII PF04851.15 ORX46258.1 - 0.0027 17.7 0.0 0.2 11.6 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ORX46258.1 - 0.011 16.1 2.9 0.32 11.3 2.9 2.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX46258.1 - 0.016 15.4 0.1 0.045 14.0 0.0 1.7 2 0 0 2 2 1 0 AAA domain AAA_33 PF13671.6 ORX46258.1 - 0.025 14.8 0.0 0.56 10.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 ORX46258.1 - 0.046 13.2 0.1 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 ORX46258.1 - 0.071 12.7 0.0 0.16 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX46258.1 - 0.074 13.6 0.0 0.28 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX46258.1 - 0.075 12.3 0.2 0.21 10.8 0.1 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_lid_4 PF17864.1 ORX46258.1 - 0.088 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 RuvB AAA lid domain Parvo_NS1 PF01057.17 ORX46258.1 - 0.14 11.3 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Ribosomal_L10 PF00466.20 ORX46259.1 - 1.5e-24 86.0 0.8 2.4e-23 82.2 0.1 2.2 2 0 0 2 2 2 1 Ribosomal protein L10 RL10P_insert PF17777.1 ORX46259.1 - 1.4e-22 79.5 0.1 2.6e-22 78.6 0.1 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 ORX46259.1 - 8.3e-14 52.0 6.5 1.7e-13 50.9 4.9 2.2 2 0 0 2 2 2 1 60s Acidic ribosomal protein KorB_C PF06613.11 ORX46259.1 - 0.05 13.6 0.0 0.14 12.1 0.0 1.8 1 1 0 1 1 1 0 KorB C-terminal beta-barrel domain Aminotran_5 PF00266.19 ORX46260.1 - 9.6e-12 44.5 0.0 1.2e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ORX46260.1 - 0.064 11.8 0.0 0.089 11.3 0.0 1.1 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX46260.1 - 0.16 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Zn_clus PF00172.18 ORX46261.1 - 2.7e-09 37.0 9.8 4.4e-09 36.3 9.8 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain EF1_GNE PF00736.19 ORX46262.1 - 1.8e-31 108.2 0.8 1.8e-31 108.2 0.8 2.0 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 ORX46262.1 - 2e-12 47.3 1.8 2e-12 47.3 1.8 2.7 3 1 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Polyketide_cyc2 PF10604.9 ORX46262.1 - 0.03 14.6 0.0 0.04 14.2 0.0 1.2 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport GST_C_3 PF14497.6 ORX46262.1 - 0.05 13.8 0.1 0.14 12.3 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Pex19 PF04614.12 ORX46263.1 - 1.7e-60 204.8 23.2 1.7e-60 204.8 23.2 1.7 1 1 1 2 2 2 1 Pex19 protein family DASH_Spc34 PF08657.10 ORX46263.1 - 0.053 13.3 3.8 0.07 12.9 3.8 1.4 1 1 0 1 1 1 0 DASH complex subunit Spc34 Laps PF10169.9 ORX46263.1 - 0.097 13.2 4.4 0.097 13.3 2.7 1.9 1 1 0 1 1 1 0 Learning-associated protein DUF445 PF04286.12 ORX46263.1 - 0.2 11.4 3.6 0.55 10.0 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF445) DUF3275 PF11679.8 ORX46263.1 - 4.1 7.3 7.0 1.1 9.1 2.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3275) DEAD PF00270.29 ORX46265.1 - 3.3e-53 180.1 0.0 2.6e-51 173.9 0.0 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX46265.1 - 3.4e-27 95.0 0.0 1.6e-26 92.8 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX46265.1 - 0.0027 17.8 0.0 0.039 13.9 0.0 2.7 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Pribosyltran PF00156.27 ORX46266.1 - 6.6e-07 29.0 0.1 1.1e-06 28.2 0.1 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain MFS_1 PF07690.16 ORX46267.1 - 5e-22 78.3 54.5 5e-22 78.3 54.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Tyr-DNA_phospho PF06087.12 ORX46268.1 - 1.1e-09 37.7 0.1 0.012 14.5 0.0 3.1 3 0 0 3 3 3 3 Tyrosyl-DNA phosphodiesterase Ras PF00071.22 ORX46269.1 - 3.3e-63 212.1 0.3 4.1e-63 211.8 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX46269.1 - 8.8e-36 122.7 0.1 1.5e-35 122.0 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX46269.1 - 4.4e-14 52.3 0.1 6e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX46269.1 - 8.9e-07 29.0 0.1 1.3e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX46269.1 - 0.00019 21.4 0.1 0.056 13.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX46269.1 - 0.00034 20.2 0.2 0.0015 18.1 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX46269.1 - 0.00092 18.7 0.0 0.0016 17.9 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ORX46269.1 - 0.0013 19.0 0.1 0.01 16.1 0.1 2.3 1 1 1 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 ORX46269.1 - 0.0022 17.4 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 ORX46269.1 - 0.0029 16.5 0.0 0.17 10.7 0.0 2.1 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) PduV-EutP PF10662.9 ORX46269.1 - 0.0086 15.8 0.0 0.026 14.3 0.0 1.9 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ORX46269.1 - 0.0088 16.4 0.1 0.015 15.6 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ORX46269.1 - 0.014 15.1 0.0 0.027 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX46269.1 - 0.031 14.8 0.2 0.057 13.9 0.2 1.6 1 1 0 1 1 1 0 ABC transporter FeoB_N PF02421.18 ORX46269.1 - 0.034 13.7 0.1 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B TniB PF05621.11 ORX46269.1 - 0.035 13.5 0.0 0.094 12.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_14 PF13173.6 ORX46269.1 - 0.04 14.0 0.1 0.12 12.4 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX46269.1 - 0.043 13.3 0.1 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_28 PF13521.6 ORX46269.1 - 0.06 13.6 0.1 0.51 10.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ORX46269.1 - 0.086 12.6 0.1 0.18 11.6 0.0 1.6 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 ORX46269.1 - 0.11 12.4 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_5 PF07728.14 ORX46269.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FA_desaturase PF00487.24 ORX46270.1 - 2.9e-42 145.3 14.3 4.1e-42 144.8 14.3 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ORX46270.1 - 2e-14 53.4 0.2 2e-14 53.4 0.2 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain DUF4133 PF13571.6 ORX46270.1 - 0.3 11.5 2.8 0.8 10.1 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) SH3_1 PF00018.28 ORX46271.1 - 2.6e-10 39.8 0.0 4.8e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX46271.1 - 1.7e-08 34.0 0.0 2.7e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX46271.1 - 2.7e-08 33.5 0.0 4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX46271.1 - 0.0097 16.2 0.1 0.026 14.8 0.1 1.7 1 0 0 1 1 1 1 Bacterial SH3 domain GLF PF03275.13 ORX46271.1 - 0.18 11.5 0.6 0.47 10.1 0.1 1.7 2 0 0 2 2 2 0 UDP-galactopyranose mutase tRNA-synt_2 PF00152.20 ORX46272.1 - 1.7e-98 329.6 0.0 2.2e-98 329.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX46272.1 - 3.5e-06 26.9 0.0 1.1e-05 25.3 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX46272.1 - 0.003 17.1 0.0 0.035 13.6 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II core domain (F) PH PF00169.29 ORX46273.1 - 4.5e-21 75.3 1.5 1e-20 74.2 1.5 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 ORX46273.1 - 1.7e-15 56.8 0.2 9.1e-15 54.5 0.0 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 ORX46273.1 - 9.5e-13 47.8 0.1 1.9e-12 46.8 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX46273.1 - 8.6e-12 44.5 0.2 1.9e-11 43.3 0.2 1.7 1 0 0 1 1 1 1 SH3 domain SAM_1 PF00536.30 ORX46273.1 - 1e-11 45.1 2.2 2e-11 44.1 0.0 2.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 ORX46273.1 - 9.7e-09 34.8 0.0 2e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain CH PF00307.31 ORX46273.1 - 1.3e-07 31.7 0.1 3.3e-07 30.5 0.0 1.7 2 0 0 2 2 1 1 Calponin homology (CH) domain PH_11 PF15413.6 ORX46273.1 - 2.6e-07 31.0 5.0 1.6e-05 25.2 5.0 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ORX46273.1 - 0.0027 18.0 1.5 0.0086 16.3 1.5 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ORX46273.1 - 0.0062 16.6 0.4 0.013 15.6 0.4 1.4 1 0 0 1 1 1 1 PH domain SAM_PNT PF02198.16 ORX46273.1 - 0.028 14.4 0.2 1.8 8.6 0.0 2.5 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 ORX46273.1 - 0.042 14.1 0.2 0.24 11.7 0.0 2.0 2 0 0 2 2 2 0 Ste50p, sterile alpha motif Piezo_RRas_bdg PF12166.8 ORX46273.1 - 0.14 11.4 0.6 0.26 10.5 0.6 1.4 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain TFIIA PF03153.13 ORX46273.1 - 8.5 6.3 26.4 0.021 14.9 8.4 3.2 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit p450 PF00067.22 ORX46274.1 - 2.2e-77 260.8 0.1 2.6e-77 260.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX46275.1 - 3.2e-76 256.9 0.0 3.9e-76 256.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Prefoldin_2 PF01920.20 ORX46276.1 - 1.2e-24 86.3 7.1 1.6e-24 85.9 7.1 1.2 1 0 0 1 1 1 1 Prefoldin subunit MitMem_reg PF13012.6 ORX46276.1 - 0.0048 17.3 0.8 0.0069 16.8 0.8 1.4 1 1 0 1 1 1 1 Maintenance of mitochondrial structure and function SYF2 PF08231.12 ORX46276.1 - 0.033 14.6 4.0 0.043 14.2 3.9 1.3 1 1 0 1 1 1 0 SYF2 splicing factor TarS_C1 PF18674.1 ORX46276.1 - 0.036 14.0 0.3 0.054 13.4 0.3 1.3 1 0 0 1 1 1 0 TarS beta-glycosyltransferase C-terminal domain 1 DUF768 PF05589.11 ORX46276.1 - 0.066 13.2 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF768) Sec2p PF06428.11 ORX46276.1 - 0.071 13.1 7.1 0.19 11.7 0.1 2.4 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p UPF0242 PF06785.11 ORX46276.1 - 0.1 12.7 5.9 0.15 12.2 5.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FAM167 PF11652.8 ORX46276.1 - 0.15 12.6 3.5 0.21 12.1 2.1 1.9 1 1 1 2 2 2 0 FAM167 PCRF PF03462.18 ORX46276.1 - 0.23 11.3 7.4 0.4 10.5 7.4 1.5 1 1 0 1 1 1 0 PCRF domain YabA PF06156.13 ORX46276.1 - 0.77 10.4 6.3 14 6.4 0.1 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Nfu_N PF08712.11 ORX46277.1 - 3.6e-30 103.9 0.0 8.3e-30 102.7 0.0 1.7 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 ORX46277.1 - 3.3e-29 100.8 0.2 6e-29 100.0 0.2 1.5 1 0 0 1 1 1 1 NifU-like domain WD40 PF00400.32 ORX46278.1 - 2.4e-09 37.6 8.0 0.00099 19.9 0.4 4.2 3 0 0 3 3 3 2 WD domain, G-beta repeat F-box-like PF12937.7 ORX46278.1 - 8.2e-06 25.6 0.9 3e-05 23.8 0.9 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX46278.1 - 0.00015 21.5 0.2 0.00052 19.8 0.2 2.0 1 0 0 1 1 1 1 F-box domain SpoIISB_antitox PF14185.6 ORX46278.1 - 0.14 12.1 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Antitoxin SpoIISB, type II toxin-antitoxin system DUF1765 PF08578.10 ORX46279.1 - 9.4e-25 87.5 2.9 2.1e-24 86.3 2.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) IQCJ-SCHIP1 PF15157.6 ORX46279.1 - 0.013 15.4 0.4 0.05 13.5 0.4 2.0 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif bZIP_1 PF00170.21 ORX46281.1 - 0.039 14.0 2.1 0.039 14.0 2.1 2.6 1 1 1 2 2 2 0 bZIP transcription factor GIT_CC PF16559.5 ORX46281.1 - 0.054 13.4 0.5 0.054 13.4 0.5 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor CCDC85 PF10226.9 ORX46281.1 - 0.086 12.5 5.6 0.11 12.2 5.6 1.2 1 0 0 1 1 1 0 CCDC85 family betaPIX_CC PF16523.5 ORX46281.1 - 0.29 11.0 5.8 0.38 10.6 3.5 1.9 1 1 1 2 2 2 0 betaPIX coiled coil Tcell_CD4_C PF12104.8 ORX46281.1 - 1.3 9.0 6.0 2.1 8.3 0.7 2.7 2 0 0 2 2 2 0 T cell CD4 receptor C terminal region bZIP_2 PF07716.15 ORX46281.1 - 2.6 8.2 14.3 0.14 12.2 2.9 2.3 1 1 1 2 2 2 0 Basic region leucine zipper Gpr1_Fun34_YaaH PF01184.19 ORX46282.1 - 0.13 11.8 0.1 0.13 11.8 0.1 3.1 2 1 1 3 3 3 0 GPR1/FUN34/yaaH family DUF2070 PF09843.9 ORX46282.1 - 0.13 10.5 11.1 0.21 9.8 11.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Peptidase_M50B PF13398.6 ORX46282.1 - 1.1 8.9 11.7 0.38 10.4 4.1 2.4 2 0 0 2 2 2 0 Peptidase M50B-like Pkinase PF00069.25 ORX46283.1 - 1.4e-72 244.2 0.0 1.9e-72 243.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46283.1 - 6.2e-35 120.7 0.0 8.6e-35 120.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX46283.1 - 1.6e-06 27.7 0.0 2.6e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX46283.1 - 0.0026 16.6 0.1 0.0043 15.9 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX46283.1 - 0.0046 16.3 0.3 0.0075 15.7 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ORX46283.1 - 0.0098 15.4 0.1 0.021 14.4 0.1 1.5 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Prefoldin PF02996.17 ORX46284.1 - 3.2e-31 107.7 0.9 3.2e-31 107.7 0.9 1.4 2 0 0 2 2 2 1 Prefoldin subunit End3 PF12761.7 ORX46284.1 - 0.049 13.8 2.0 0.28 11.3 2.0 2.0 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 Syntaxin-6_N PF09177.11 ORX46284.1 - 0.3 11.7 4.7 11 6.7 4.7 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Acyl-CoA_dh_1 PF00441.24 ORX46285.1 - 2.9e-39 134.7 0.1 4.1e-39 134.2 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 ORX46285.1 - 5.6e-22 77.7 0.1 1.6e-21 76.2 0.1 1.8 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 ORX46285.1 - 2.7e-21 75.6 0.1 5.5e-21 74.6 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX46285.1 - 4.4e-19 69.2 0.0 1.2e-18 67.9 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX46285.1 - 6.3e-08 33.0 0.0 1.1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PPO1_DWL PF12142.8 ORX46285.1 - 0.054 13.3 0.3 0.11 12.3 0.3 1.5 1 0 0 1 1 1 0 Polyphenol oxidase middle domain Pkinase PF00069.25 ORX46286.1 - 1.7e-16 60.4 0.5 3.1e-11 43.2 0.1 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46286.1 - 1.8e-07 30.7 0.8 1.6e-05 24.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Bromodomain PF00439.25 ORX46286.1 - 7.8e-06 25.9 0.0 2.5e-05 24.3 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Kdo PF06293.14 ORX46286.1 - 0.00063 19.2 0.2 0.0013 18.2 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX46286.1 - 0.036 12.9 0.0 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 ORX46286.1 - 0.085 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase EI24 PF07264.11 ORX46287.1 - 3.3e-12 47.0 0.3 4.3e-12 46.6 0.3 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Pyr_redox_2 PF07992.14 ORX46288.1 - 2.1e-50 171.7 0.0 2.6e-50 171.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX46288.1 - 1.7e-11 44.5 0.0 1.1e-09 38.7 0.0 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX46288.1 - 8.3e-06 25.3 0.0 0.068 12.4 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX46288.1 - 0.043 12.5 0.7 0.31 9.7 0.0 2.1 1 1 1 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.6 ORX46288.1 - 0.15 12.0 0.7 3.7 7.5 0.3 3.1 2 1 0 2 2 2 0 FAD-NAD(P)-binding Adeno_E3_CR2 PF02439.15 ORX46289.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Romo1 PF10247.9 ORX46289.1 - 0.31 11.4 1.9 1.5 9.2 0.3 2.2 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Gly-zipper_Omp PF13488.6 ORX46289.1 - 0.83 9.7 24.4 2.6 8.1 10.8 2.5 2 0 0 2 2 2 0 Glycine zipper Glyco_transf_15 PF01793.16 ORX46290.1 - 2.7e-113 378.5 1.7 3.4e-113 378.2 1.7 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase NAP PF00956.18 ORX46290.1 - 0.057 12.6 0.1 0.097 11.8 0.1 1.5 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) PfkB PF00294.24 ORX46291.1 - 6.9e-58 196.3 2.0 8.4e-58 196.0 2.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase DUF730 PF05325.11 ORX46292.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF730) Cation_ATPase_C PF00689.21 ORX46293.1 - 1.8e-46 158.1 12.8 1.8e-46 158.1 12.8 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ORX46293.1 - 2.2e-33 115.3 0.5 2.2e-33 115.3 0.5 3.0 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 ORX46293.1 - 5.1e-21 74.5 0.0 1e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX46293.1 - 1.3e-20 74.7 0.0 2.6e-20 73.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX46293.1 - 5.8e-07 29.1 0.1 1.6e-06 27.7 0.1 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX46293.1 - 2.2e-05 24.3 0.3 0.0024 17.6 0.4 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SNF2_N PF00176.23 ORX46294.1 - 3e-66 223.5 4.3 1.4e-60 204.9 0.9 3.2 2 1 1 3 3 3 3 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX46294.1 - 7.5e-17 61.7 0.0 2.9e-16 59.8 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX46294.1 - 4e-07 30.2 0.0 1.2e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Zn_protease PF05618.11 ORX46294.1 - 0.16 11.8 0.1 0.6 10.0 0.0 1.9 2 0 0 2 2 2 0 Putative ATP-dependant zinc protease Sel1 PF08238.12 ORX46295.1 - 2.9e-98 320.1 85.2 2.9e-08 34.1 0.1 31.2 32 0 0 32 32 32 21 Sel1 repeat TPR_2 PF07719.17 ORX46295.1 - 0.016 15.2 0.2 0.016 15.2 0.2 16.1 17 0 0 17 17 17 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX46295.1 - 0.036 14.7 56.7 0.11 13.2 0.1 12.6 12 1 1 13 13 13 0 Tetratricopeptide repeat RNase_H_2 PF13482.6 ORX46295.1 - 0.069 13.1 0.1 0.23 11.5 0.1 1.9 1 0 0 1 1 1 0 RNase_H superfamily TPR_6 PF13174.6 ORX46295.1 - 1.4 9.7 35.2 12 6.8 0.1 12.6 15 0 0 15 15 15 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX46295.1 - 3.4 7.8 22.3 0.88 9.6 1.1 6.5 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX46295.1 - 5.4 7.3 47.7 1.3 9.3 0.1 10.7 13 0 0 13 13 13 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ORX46295.1 - 8.9 6.3 59.3 5.3 7.0 0.0 15.1 18 0 0 18 18 18 0 Tetratricopeptide repeat EXS PF03124.14 ORX46296.1 - 1.9e-68 231.3 20.8 2.2e-68 231.0 20.8 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ORX46297.1 - 6.9e-39 134.9 5.2 2.4e-18 67.3 0.0 3.0 2 1 1 3 3 3 3 SPX domain DUF1203 PF06718.11 ORX46298.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1203) RNB PF00773.19 ORX46300.1 - 1.1e-91 307.6 0.0 1.8e-91 306.9 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX46300.1 - 6e-19 67.9 0.1 2.1e-18 66.1 0.0 2.0 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 ORX46300.1 - 4.9e-10 39.4 0.1 1.6e-06 28.2 0.0 3.0 3 0 0 3 3 3 2 Cold shock domain Rrp44_CSD1 PF17216.3 ORX46300.1 - 1.3e-08 34.7 0.1 2.7e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 ORX46300.1 - 0.00011 22.1 0.0 0.00077 19.4 0.0 2.4 1 1 0 1 1 1 1 S1 domain PIN_4 PF13638.6 ORX46300.1 - 0.005 17.1 0.0 0.013 15.8 0.0 1.7 1 0 0 1 1 1 1 PIN domain DUF2031 PF09592.10 ORX46300.1 - 0.05 13.1 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) OB_RNB PF08206.11 ORX46300.1 - 0.077 12.7 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 Ribonuclease B OB domain GCP_N_terminal PF17681.1 ORX46301.1 - 6.6e-21 75.2 0.6 1.8e-20 73.8 0.6 1.6 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal ThiF PF00899.21 ORX46302.1 - 2.7e-51 174.3 0.0 4.2e-51 173.7 0.0 1.2 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 ORX46302.1 - 0.026 15.0 0.0 0.067 13.7 0.0 1.7 1 0 0 1 1 1 0 Rhodanese-like domain Pox_A_type_inc PF04508.12 ORX46302.1 - 0.027 14.3 0.5 0.074 12.9 0.5 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat IFP_35_N PF07334.13 ORX46302.1 - 0.57 10.3 3.1 1.3 9.1 3.1 1.6 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus SMC_Nse1 PF07574.13 ORX46303.1 - 5.1e-27 95.0 2.1 6.5e-26 91.4 2.1 2.1 1 1 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 ORX46303.1 - 8e-09 35.7 13.4 1.5e-08 34.8 13.4 1.5 1 0 0 1 1 1 1 RING-like domain zf-RING_2 PF13639.6 ORX46303.1 - 0.00017 21.8 10.3 0.00033 20.9 10.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-HC5HC2H PF13771.6 ORX46303.1 - 0.0071 16.6 3.6 0.018 15.3 3.6 1.7 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX46303.1 - 0.014 15.6 3.0 0.027 14.6 3.0 1.5 1 0 0 1 1 1 0 PHD-zinc-finger like domain PMG PF05287.12 ORX46303.1 - 0.038 14.0 0.7 0.058 13.4 0.7 1.2 1 0 0 1 1 1 0 PMG protein zf-tcix PF14952.6 ORX46303.1 - 0.23 11.1 4.5 1.5 8.5 0.7 2.3 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-DNL PF05180.12 ORX46303.1 - 0.41 10.6 5.7 0.97 9.4 5.7 1.7 1 1 0 1 1 1 0 DNL zinc finger Homeodomain PF00046.29 ORX46304.1 - 7.4e-18 64.2 1.0 1.5e-17 63.1 1.0 1.6 1 0 0 1 1 1 1 Homeodomain YdaS_antitoxin PF15943.5 ORX46304.1 - 0.042 13.7 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_23 PF13384.6 ORX46304.1 - 0.06 13.2 0.3 0.06 13.2 0.3 1.8 2 0 0 2 2 2 0 Homeodomain-like domain Homeobox_KN PF05920.11 ORX46304.1 - 0.097 12.6 1.0 0.36 10.8 0.2 2.2 2 0 0 2 2 2 0 Homeobox KN domain FAD-oxidase_C PF02913.19 ORX46305.1 - 4.4e-56 190.3 0.0 5.6e-56 190.0 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX46305.1 - 1.3e-37 128.7 0.0 2.5e-37 127.7 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DUF1490 PF07371.12 ORX46305.1 - 0.19 11.8 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1490) DUF2347 PF09804.9 ORX46306.1 - 2e-58 198.2 0.1 8.5e-57 192.9 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 ORX46306.1 - 2.2e-09 37.3 0.0 4.9e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 ORX46306.1 - 0.00011 21.0 0.3 0.19 10.4 0.0 2.8 2 1 0 3 3 3 2 Transport protein Avl9 DUF4484 PF14831.6 ORX46306.1 - 0.0052 16.9 0.0 0.018 15.1 0.0 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4484) DUF2408 PF10303.9 ORX46307.1 - 5.2e-46 156.5 1.6 1e-22 81.2 0.0 4.6 3 2 1 4 4 4 4 Protein of unknown function (DUF2408) Seryl_tRNA_N PF02403.22 ORX46307.1 - 0.0038 17.4 2.2 1 9.6 0.1 3.2 3 0 0 3 3 3 2 Seryl-tRNA synthetase N-terminal domain DegS PF05384.11 ORX46307.1 - 0.0055 16.2 1.3 8.9 5.8 0.0 3.3 2 1 1 3 3 3 2 Sensor protein DegS RecG_N PF17190.4 ORX46307.1 - 0.093 13.5 0.5 8.5 7.2 0.0 3.7 3 1 0 3 3 3 0 RecG N-terminal helical domain Snapin_Pallidin PF14712.6 ORX46307.1 - 0.13 12.7 2.7 9.6 6.7 0.1 3.9 4 0 0 4 4 4 0 Snapin/Pallidin Sec34 PF04136.15 ORX46307.1 - 0.35 10.7 5.0 4 7.3 0.2 3.5 3 1 1 4 4 4 0 Sec34-like family APG6_N PF17675.1 ORX46307.1 - 1.7 9.2 6.8 15 6.1 1.5 3.1 2 1 1 3 3 3 0 Apg6 coiled-coil region DEAD PF00270.29 ORX46308.1 - 2.8e-39 134.7 0.6 6.9e-39 133.4 0.2 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX46308.1 - 3.8e-35 120.6 0.3 7.7e-32 109.9 0.1 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ORX46308.1 - 8.5e-08 32.4 0.0 2.3e-07 31.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ORX46308.1 - 4.1e-05 23.4 0.4 0.0029 17.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX46308.1 - 0.0031 17.9 0.1 0.0077 16.6 0.1 1.7 1 0 0 1 1 1 1 AAA domain KLRAQ PF10205.9 ORX46308.1 - 0.022 15.0 4.7 0.065 13.5 4.7 1.8 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Flavi_DEAD PF07652.14 ORX46308.1 - 0.033 14.1 0.3 0.092 12.7 0.1 1.8 2 0 0 2 2 2 0 Flavivirus DEAD domain DUF3993 PF13158.6 ORX46308.1 - 0.035 14.3 0.0 0.082 13.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3993) KH_1 PF00013.29 ORX46310.1 - 9.3e-14 51.0 0.1 5.4e-08 32.6 0.0 4.5 5 0 0 5 5 5 3 KH domain DUF5345 PF17280.2 ORX46311.1 - 2.1 8.4 3.9 2.4 8.2 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) PEMT PF04191.13 ORX46312.1 - 1.5e-11 44.6 3.1 1.5e-11 44.6 3.1 2.0 3 0 0 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 ORX46312.1 - 2.6e-09 37.4 2.1 3.1e-09 37.1 0.4 2.0 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF1295 PF06966.12 ORX46312.1 - 1.6e-06 27.9 5.2 3.2e-06 26.8 5.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 ORX46312.1 - 3.4e-05 22.8 0.9 5.4e-05 22.1 0.9 1.3 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Steroid_dh PF02544.16 ORX46312.1 - 0.67 9.9 6.3 1.9 8.4 5.7 1.9 1 1 0 1 1 1 0 3-oxo-5-alpha-steroid 4-dehydrogenase Ras PF00071.22 ORX46313.1 - 1.1e-47 161.6 0.0 1.3e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX46313.1 - 1.7e-18 67.0 0.0 3.1e-18 66.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX46313.1 - 5.5e-06 25.9 0.0 1.4e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 ORX46313.1 - 0.0046 17.4 0.0 0.0079 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ORX46313.1 - 0.02 15.4 0.0 0.031 14.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NACHT PF05729.12 ORX46313.1 - 0.023 14.6 0.0 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_24 PF13479.6 ORX46313.1 - 0.028 14.1 0.0 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ORX46313.1 - 0.13 12.2 0.0 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 ORX46313.1 - 0.13 12.5 0.0 0.33 11.2 0.0 1.6 2 0 0 2 2 2 0 AAA domain BHD_3 PF10405.9 ORX46314.1 - 1.4e-24 86.3 0.0 3.5e-24 85.0 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 ORX46314.1 - 3.5e-16 58.8 0.1 1.2e-15 57.1 0.0 2.0 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 ORX46314.1 - 2.1e-14 53.4 1.9 9.5e-14 51.3 1.9 2.1 1 1 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_2 PF10404.9 ORX46314.1 - 1.7e-11 44.9 1.1 1.7e-11 44.9 1.1 2.4 3 0 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 ORX46314.1 - 0.0002 21.8 0.0 0.00097 19.6 0.0 2.2 1 1 0 1 1 1 1 Transglutaminase-like superfamily Asp PF00026.23 ORX46315.1 - 5.6e-55 187.0 1.8 6.7e-55 186.7 1.8 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX46315.1 - 8e-12 45.8 1.1 1.7e-08 34.9 0.3 3.3 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX46315.1 - 1.6e-07 31.8 0.2 0.011 16.3 0.0 3.3 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX46315.1 - 4.1e-05 24.0 0.0 0.41 11.2 0.0 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 ORX46315.1 - 0.027 14.2 0.0 0.94 9.2 0.0 2.4 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal Pro_isomerase PF00160.21 ORX46316.1 - 3e-52 177.1 0.0 3.3e-52 176.9 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF3830 PF12903.7 ORX46316.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3830) FHA PF00498.26 ORX46317.1 - 1.3e-17 63.9 0.0 2.3e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX46317.1 - 4.8e-05 23.6 0.0 0.0086 16.4 0.0 2.3 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain GAGE PF05831.11 ORX46317.1 - 0.057 14.0 2.9 0.099 13.2 2.9 1.5 1 0 0 1 1 1 0 GAGE protein N6-adenineMlase PF10237.9 ORX46318.1 - 0.093 12.5 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase EF-hand_1 PF00036.32 ORX46319.1 - 1.4e-38 127.6 15.2 5.6e-10 38.0 0.3 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX46319.1 - 6.3e-34 116.3 6.4 6.9e-18 64.9 0.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX46319.1 - 3.2e-29 98.3 9.9 5e-09 35.4 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ORX46319.1 - 6.9e-26 89.9 11.7 7.6e-13 48.1 0.3 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ORX46319.1 - 3.1e-23 80.2 14.2 9.7e-07 28.0 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ORX46319.1 - 6.2e-12 45.7 0.3 3.2e-07 30.6 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX46319.1 - 9.9e-11 41.5 3.8 3.5e-06 26.9 0.3 2.4 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX46319.1 - 4.3e-09 36.7 0.5 0.00065 20.0 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 ORX46319.1 - 3.4e-07 31.1 0.4 4.7e-05 24.2 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain UPF0154 PF03672.13 ORX46319.1 - 1.6e-05 24.9 0.1 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 ORX46319.1 - 0.0001 22.3 3.5 0.0002 21.4 0.7 2.4 2 1 0 2 2 2 1 Ca2+ insensitive EF hand DUF5580 PF17743.1 ORX46319.1 - 0.00017 20.3 0.0 0.00017 20.2 0.0 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5580) dCache_2 PF08269.11 ORX46319.1 - 0.0017 17.6 0.1 0.25 10.5 0.1 2.1 1 1 0 2 2 2 1 Cache domain TerB PF05099.13 ORX46319.1 - 0.0031 17.5 4.8 0.55 10.2 0.2 3.0 1 1 3 4 4 4 1 Tellurite resistance protein TerB Caleosin PF05042.13 ORX46319.1 - 0.0036 17.2 3.6 5.5 6.9 0.3 3.2 1 1 2 3 3 3 1 Caleosin related protein DUF1103 PF06513.11 ORX46319.1 - 0.0042 16.7 0.5 0.0047 16.6 0.5 1.1 1 0 0 1 1 1 1 Repeat of unknown function (DUF1103) SurA_N_2 PF13623.6 ORX46319.1 - 0.01 15.7 5.6 0.49 10.2 3.0 2.2 1 1 1 2 2 2 0 SurA N-terminal domain Herpes_UL36 PF03586.13 ORX46319.1 - 0.02 14.2 0.1 20 4.4 0.1 2.9 2 1 1 3 3 3 0 Herpesvirus UL36 tegument protein Dockerin_1 PF00404.18 ORX46319.1 - 0.042 14.0 3.2 1.6 9.0 0.1 2.6 2 2 0 2 2 2 0 Dockerin type I domain EF-hand_14 PF17959.1 ORX46319.1 - 0.052 13.9 1.0 7.3 7.0 0.1 2.4 2 0 0 2 2 2 0 EF-hand domain Adenine_glyco PF03352.13 ORX46319.1 - 0.064 13.0 0.1 0.12 12.2 0.1 1.3 1 1 0 1 1 1 0 Methyladenine glycosylase SelB-wing_2 PF09106.11 ORX46319.1 - 0.13 12.4 0.1 0.42 10.8 0.1 1.8 2 0 0 2 2 1 0 Elongation factor SelB, winged helix RNA_pol_Rpb4 PF03874.16 ORX46319.1 - 0.15 12.4 1.6 1.9 8.9 0.7 2.4 1 1 1 2 2 2 0 RNA polymerase Rpb4 60KD_IMP PF02096.20 ORX46320.1 - 5.7e-06 26.3 0.0 1.2e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 60Kd inner membrane protein Cob_adeno_trans PF01923.18 ORX46321.1 - 2.5e-56 190.3 0.0 2.8e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase LUC7 PF03194.15 ORX46322.1 - 1.8e-67 227.7 18.2 2.4e-67 227.2 18.2 1.1 1 0 0 1 1 1 1 LUC7 N_terminus DUF4175 PF13779.6 ORX46322.1 - 0.00049 18.2 7.1 0.00073 17.6 7.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) zf-RRN7 PF11781.8 ORX46322.1 - 0.1 12.3 0.1 0.25 11.1 0.1 1.7 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF4407 PF14362.6 ORX46322.1 - 0.87 8.9 6.6 1.1 8.6 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 ORX46322.1 - 1.6 6.5 10.5 2.3 6.0 10.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EMP24_GP25L PF01105.24 ORX46322.1 - 1.7 8.6 8.4 3 7.8 8.4 1.5 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD RNB PF00773.19 ORX46323.1 - 9.5e-101 337.4 0.1 1.3e-100 336.9 0.1 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX46323.1 - 8.4e-19 67.4 0.0 1.7e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_S1 PF17215.3 ORX46323.1 - 6.5e-14 51.7 1.1 1.9e-13 50.2 1.1 1.8 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 ORX46323.1 - 1.3e-13 50.9 0.0 3e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain PIN_4 PF13638.6 ORX46323.1 - 6.9e-13 49.0 0.2 1.8e-12 47.7 0.2 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 ORX46323.1 - 5.1e-08 33.0 0.0 2.7e-07 30.6 0.0 2.4 1 0 0 1 1 1 1 Cold shock domain Dis3l2_C_term PF17877.1 ORX46323.1 - 0.00096 19.4 0.1 0.0027 18.0 0.1 1.7 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Homeodomain PF00046.29 ORX46324.1 - 7.1e-20 70.6 3.0 7.6e-20 70.5 3.0 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX46324.1 - 0.021 14.7 0.2 0.036 14.0 0.2 1.4 1 0 0 1 1 1 0 Homeobox KN domain DUF167 PF02594.16 ORX46324.1 - 0.059 13.5 0.0 0.06 13.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised ACR, YggU family COG1872 Diphthamide_syn PF01866.17 ORX46325.1 - 1.3e-95 320.4 2.1 2.2e-95 319.6 2.1 1.4 1 1 0 1 1 1 1 Putative diphthamide synthesis protein Actin PF00022.19 ORX46325.1 - 0.077 11.6 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Actin eRF1_1 PF03463.15 ORX46326.1 - 2.7e-50 169.7 0.1 4.7e-50 168.9 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_2 PF03464.15 ORX46326.1 - 4.3e-29 101.5 0.1 6.7e-29 100.9 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ORX46326.1 - 6.8e-23 81.3 0.0 1.4e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 3 EAP30 PF04157.16 ORX46327.1 - 3.3e-37 128.0 0.5 4.9e-37 127.5 0.5 1.3 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 ORX46327.1 - 2.4e-22 78.9 0.1 5.2e-22 77.8 0.1 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 GRAM PF02893.20 ORX46327.1 - 5e-06 26.4 0.1 4.1e-05 23.4 0.0 2.4 3 0 0 3 3 3 1 GRAM domain zf-RanBP PF00641.18 ORX46327.1 - 2.3e-05 23.6 12.9 0.0056 16.0 3.8 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ORX46327.1 - 0.0014 18.6 7.6 0.16 12.1 0.0 3.3 3 0 0 3 3 3 2 Sec23/Sec24 zinc finger DZR PF12773.7 ORX46327.1 - 0.018 15.0 8.9 0.018 15.0 8.9 2.3 2 1 1 3 3 3 0 Double zinc ribbon RPW8 PF05659.11 ORX46327.1 - 0.022 14.4 0.2 0.044 13.5 0.2 1.4 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 zinc_ribbon_15 PF17032.5 ORX46327.1 - 0.028 15.2 7.3 0.069 13.9 7.3 1.7 1 0 0 1 1 1 0 zinc-ribbon family Vps36-NZF-N PF16988.5 ORX46327.1 - 0.06 12.8 13.5 0.017 14.5 6.0 2.9 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PH_TFIIH PF08567.11 ORX46327.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain Nup_retrotrp_bd PF10599.9 ORX46327.1 - 0.22 12.2 4.5 0.45 11.2 4.5 1.5 1 0 0 1 1 1 0 Retro-transposon transporting motif LRV_FeS PF05484.11 ORX46327.1 - 4.3 7.4 5.3 28 4.8 0.6 2.5 2 0 0 2 2 2 0 LRV protein FeS4 cluster zf-LYAR PF08790.11 ORX46328.1 - 2.5e-13 49.7 5.2 5.4e-13 48.6 5.2 1.6 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger RNase_P_pop3 PF08228.11 ORX46329.1 - 1.1e-08 35.3 0.1 1.3e-08 35.1 0.1 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 SET PF00856.28 ORX46330.1 - 7e-18 65.6 0.0 1.4e-17 64.6 0.0 1.5 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 ORX46330.1 - 0.00018 22.2 0.0 0.00047 20.9 0.0 1.7 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Cu-oxidase_3 PF07732.15 ORX46331.1 - 4.1e-30 104.2 3.2 5.5e-30 103.8 0.3 2.8 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX46331.1 - 3.7e-29 101.9 0.1 9.2e-28 97.4 0.0 2.3 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX46331.1 - 2.7e-21 75.7 15.0 3.7e-19 68.8 7.4 4.2 2 2 0 3 3 3 2 Multicopper oxidase CARDB PF07705.11 ORX46331.1 - 0.035 14.3 0.1 0.11 12.8 0.1 1.8 1 0 0 1 1 1 0 CARDB DUF1116 PF06545.11 ORX46332.1 - 0.052 13.0 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) Mod_r PF07200.13 ORX46333.1 - 0.0062 16.7 7.3 0.77 9.9 0.2 2.4 2 0 0 2 2 2 2 Modifier of rudimentary (Mod(r)) protein YbaJ PF10757.9 ORX46334.1 - 0.062 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Biofilm formation regulator YbaJ Aminotran_3 PF00202.21 ORX46335.1 - 2.8e-119 398.4 0.0 3.4e-119 398.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ORX46335.1 - 0.0071 15.6 0.0 0.013 14.7 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II DNA_ligase_IV PF11411.8 ORX46335.1 - 0.021 14.9 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 DNA ligase IV Nudix_N_2 PF14803.6 ORX46336.1 - 0.41 10.6 2.4 2.1 8.3 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal YEATS PF03366.16 ORX46337.1 - 4.5e-21 74.6 0.1 8.8e-21 73.7 0.1 1.4 1 0 0 1 1 1 1 YEATS family zf-CCHC PF00098.23 ORX46337.1 - 0.04 14.0 1.2 0.04 14.0 1.2 1.9 2 0 0 2 2 2 0 Zinc knuckle SE PF08491.10 ORX46338.1 - 5.2e-108 360.3 0.0 6.7e-108 359.9 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 ORX46338.1 - 6.5e-10 38.8 0.0 4.6e-09 36.0 0.0 2.0 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX46338.1 - 6.6e-06 25.9 0.1 0.00077 19.1 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ORX46338.1 - 1.2e-05 24.6 0.0 1.8e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Thi4 PF01946.17 ORX46338.1 - 0.0004 19.7 0.1 0.00085 18.6 0.1 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 ORX46338.1 - 0.0045 16.3 0.1 0.0071 15.6 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX46338.1 - 0.0079 15.3 1.8 0.064 12.3 0.7 2.1 2 0 0 2 2 2 1 FAD binding domain HI0933_like PF03486.14 ORX46338.1 - 0.008 14.9 0.1 0.012 14.4 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 ORX46338.1 - 0.0099 15.3 0.4 0.016 14.6 0.4 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX46338.1 - 0.011 15.9 0.3 0.021 15.0 0.3 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ORX46338.1 - 0.027 15.0 0.1 0.059 13.9 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ORX46338.1 - 0.035 13.4 0.1 0.068 12.4 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GDI PF00996.18 ORX46338.1 - 0.17 10.4 0.0 0.25 9.8 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Lycopene_cycl PF05834.12 ORX46338.1 - 0.45 9.5 1.1 0.94 8.4 0.3 1.9 3 0 0 3 3 3 0 Lycopene cyclase protein BCDHK_Adom3 PF10436.9 ORX46339.1 - 1.3e-39 135.7 0.6 2.4e-39 134.8 0.6 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX46339.1 - 0.00013 22.4 0.0 0.00032 21.2 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pex14_N PF04695.13 ORX46340.1 - 8.2e-27 94.8 10.0 2.9e-26 93.0 0.6 3.2 2 2 1 3 3 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF1664 PF07889.12 ORX46340.1 - 4e-07 30.1 0.4 1.1e-06 28.7 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) DUF812 PF05667.11 ORX46340.1 - 1.2e-05 24.5 3.3 1.2e-05 24.4 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Baculo_PEP_C PF04513.12 ORX46340.1 - 5.4e-05 23.3 2.5 0.00011 22.3 2.5 1.5 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus zf-C4H2 PF10146.9 ORX46340.1 - 0.00098 19.5 3.0 0.0018 18.6 3.0 1.5 1 0 0 1 1 1 1 Zinc finger-containing protein DUF4795 PF16043.5 ORX46340.1 - 0.0013 18.4 12.0 0.011 15.4 10.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4795) Laminin_II PF06009.12 ORX46340.1 - 0.0018 18.3 9.2 0.0018 18.3 9.2 2.1 1 1 1 2 2 2 1 Laminin Domain II FapA PF03961.13 ORX46340.1 - 0.0031 16.2 6.4 0.0055 15.4 6.4 1.4 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF948 PF06103.11 ORX46340.1 - 0.0041 17.4 2.7 0.01 16.1 0.3 2.3 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) PilJ PF13675.6 ORX46340.1 - 0.0042 17.1 4.0 0.011 15.8 0.5 2.6 1 1 1 2 2 2 1 Type IV pili methyl-accepting chemotaxis transducer N-term Exonuc_VII_L PF02601.15 ORX46340.1 - 0.011 15.4 2.2 0.016 14.8 2.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3584 PF12128.8 ORX46340.1 - 0.019 12.6 10.7 0.025 12.2 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.12 ORX46340.1 - 0.03 14.8 11.4 0.99 9.9 0.8 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein LMBR1 PF04791.16 ORX46340.1 - 0.036 13.0 0.4 0.048 12.6 0.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein YkyA PF10368.9 ORX46340.1 - 0.04 13.6 15.9 0.07 12.8 15.9 1.4 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Syntaxin PF00804.25 ORX46340.1 - 0.045 13.4 9.3 0.11 12.2 9.3 1.5 1 1 0 1 1 1 0 Syntaxin Vps53_N PF04100.12 ORX46340.1 - 0.055 12.4 7.3 0.083 11.8 7.3 1.2 1 0 0 1 1 1 0 Vps53-like, N-terminal GTP-bdg_M PF16360.5 ORX46340.1 - 0.057 14.0 3.6 0.12 13.0 0.0 2.9 2 1 1 3 3 2 0 GTP-binding GTPase Middle Region Fib_alpha PF08702.10 ORX46340.1 - 0.057 13.6 11.4 0.11 12.6 11.4 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family LXG PF04740.12 ORX46340.1 - 0.057 13.1 11.2 0.079 12.7 10.1 1.8 1 1 0 1 1 1 0 LXG domain of WXG superfamily APG17 PF04108.12 ORX46340.1 - 0.057 12.5 8.1 0.084 12.0 8.1 1.3 1 0 0 1 1 1 0 Autophagy protein Apg17 EzrA PF06160.12 ORX46340.1 - 0.062 11.5 11.4 0.095 10.9 11.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Prominin PF05478.11 ORX46340.1 - 0.065 11.2 3.7 0.083 10.8 3.7 1.1 1 0 0 1 1 1 0 Prominin HATPase_c_4 PF13749.6 ORX46340.1 - 0.074 13.2 0.4 6 7.1 0.0 2.6 2 1 0 2 2 2 0 Putative ATP-dependent DNA helicase recG C-terminal SKA2 PF16740.5 ORX46340.1 - 0.075 12.8 8.2 1.4 8.8 0.3 2.4 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Golgin_A5 PF09787.9 ORX46340.1 - 0.076 12.5 16.3 0.12 11.9 16.3 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 TMPIT PF07851.13 ORX46340.1 - 0.089 12.0 10.4 0.14 11.4 10.4 1.3 1 0 0 1 1 1 0 TMPIT-like protein TRADD_N PF09034.10 ORX46340.1 - 0.094 12.8 4.6 0.53 10.3 0.5 2.3 1 1 1 2 2 2 0 TRADD, N-terminal domain Phasin PF05597.11 ORX46340.1 - 0.11 12.5 6.7 0.091 12.8 4.9 1.8 2 0 0 2 2 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) IFT57 PF10498.9 ORX46340.1 - 0.12 11.4 11.6 0.21 10.5 11.6 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 F_actin_bind PF08919.10 ORX46340.1 - 0.12 12.5 6.8 1.8 8.7 6.9 2.6 2 1 0 2 2 2 0 F-actin binding UPF0242 PF06785.11 ORX46340.1 - 0.13 12.3 14.0 0.059 13.5 11.6 1.6 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus Phage_GPO PF05929.11 ORX46340.1 - 0.13 11.8 4.2 0.24 11.0 4.2 1.5 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3573 PF12097.8 ORX46340.1 - 0.13 11.0 2.0 0.18 10.6 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF5320 PF17253.2 ORX46340.1 - 0.14 13.2 4.6 0.15 13.1 0.0 2.9 2 1 1 3 3 1 0 Family of unknown function (DUF5320) FTO_CTD PF12934.7 ORX46340.1 - 0.16 11.8 2.5 0.23 11.2 2.5 1.3 1 0 0 1 1 1 0 FTO C-terminal domain Spc7 PF08317.11 ORX46340.1 - 0.16 10.8 17.4 0.24 10.2 17.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein BshC PF10079.9 ORX46340.1 - 0.16 10.7 5.9 0.24 10.1 5.9 1.2 1 0 0 1 1 1 0 Bacillithiol biosynthesis BshC CorA PF01544.18 ORX46340.1 - 0.22 10.8 9.6 0.3 10.3 9.6 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Sec20 PF03908.13 ORX46340.1 - 0.23 11.4 8.2 0.54 10.2 3.9 2.5 1 1 1 2 2 2 0 Sec20 DUF4407 PF14362.6 ORX46340.1 - 0.31 10.3 5.8 0.51 9.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4611 PF15387.6 ORX46340.1 - 0.37 11.0 9.1 4.4 7.6 0.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) APG6_N PF17675.1 ORX46340.1 - 0.45 11.0 21.5 2.4 8.7 21.5 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region ISG65-75 PF11727.8 ORX46340.1 - 0.48 9.6 6.3 0.75 9.0 6.3 1.4 1 0 0 1 1 1 0 Invariant surface glycoprotein AcylCoA_dehyd_C PF12186.8 ORX46340.1 - 0.53 10.4 5.5 2.9 8.0 0.7 2.2 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal HEPN_AbiU2 PF18734.1 ORX46340.1 - 0.58 9.6 6.9 0.32 10.5 4.3 1.7 1 1 1 2 2 2 0 AbiU2 RPW8 PF05659.11 ORX46340.1 - 0.65 9.7 5.4 1.7 8.3 5.3 1.8 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 STAT_alpha PF01017.20 ORX46340.1 - 0.67 9.8 12.0 1.1 9.1 12.0 1.3 1 0 0 1 1 1 0 STAT protein, all-alpha domain DUF4164 PF13747.6 ORX46340.1 - 0.83 10.0 16.3 0.52 10.6 3.3 3.1 2 1 1 3 3 2 0 Domain of unknown function (DUF4164) V_ATPase_I PF01496.19 ORX46340.1 - 0.97 7.3 5.0 1.6 6.6 5.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3340 PF11818.8 ORX46340.1 - 0.99 9.5 14.0 2.7 8.1 12.6 2.2 2 1 0 2 2 1 0 C-terminal domain of tail specific protease (DUF3340) Tropomyosin PF00261.20 ORX46340.1 - 1 8.7 19.8 4.9 6.4 19.8 1.9 1 1 0 1 1 1 0 Tropomyosin DUF4208 PF13907.6 ORX46340.1 - 1 9.8 8.0 1 9.8 3.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Phage_Mu_Gam PF07352.12 ORX46340.1 - 1.1 9.2 13.9 0.1 12.5 2.0 2.5 2 1 1 3 3 2 0 Bacteriophage Mu Gam like protein Cluap1 PF10234.9 ORX46340.1 - 1.2 8.5 11.5 1.8 7.9 11.5 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 XhlA PF10779.9 ORX46340.1 - 1.3 9.3 18.8 0.9 9.8 4.1 3.4 3 0 0 3 3 3 0 Haemolysin XhlA COG2 PF06148.11 ORX46340.1 - 1.3 9.1 10.9 6.3 6.9 3.7 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RmuC PF02646.16 ORX46340.1 - 1.5 7.9 12.7 0.73 8.9 5.5 2.3 1 1 1 2 2 2 0 RmuC family Fmp27_WPPW PF10359.9 ORX46340.1 - 1.6 7.5 13.0 2.9 6.7 13.0 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2408 PF10303.9 ORX46340.1 - 1.8 9.2 10.6 4.1 8.0 10.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Baculo_p24 PF05073.12 ORX46340.1 - 1.8 8.3 8.0 5.7 6.7 8.1 1.7 1 1 0 1 1 1 0 Baculovirus P24 capsid protein Med9 PF07544.13 ORX46340.1 - 2.1 8.5 16.1 0.76 9.9 3.8 2.6 2 1 1 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 YlqD PF11068.8 ORX46340.1 - 2.7 8.4 14.5 3 8.2 13.5 1.6 1 1 0 1 1 1 0 YlqD protein DUF1043 PF06295.12 ORX46340.1 - 3 7.9 11.9 2.5 8.1 8.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) CHDCT2 PF08074.11 ORX46340.1 - 3 8.0 7.6 1.3 9.2 3.4 2.3 2 1 1 3 3 2 0 CHDCT2 (NUC038) domain BST2 PF16716.5 ORX46340.1 - 3.1 8.4 14.9 19 5.9 10.6 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF4200 PF13863.6 ORX46340.1 - 3.2 8.2 19.1 1.4e+02 2.9 19.1 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1319 PF07028.11 ORX46340.1 - 3.2 8.0 14.4 32 4.8 0.8 4.0 2 1 2 4 4 4 0 Protein of unknown function (DUF1319) PCRF PF03462.18 ORX46340.1 - 3.4 7.5 10.7 6.1 6.7 10.7 1.4 1 0 0 1 1 1 0 PCRF domain zf-ZPR1 PF03367.13 ORX46340.1 - 3.5 7.5 6.5 4.1 7.2 5.6 1.6 1 1 0 1 1 1 0 ZPR1 zinc-finger domain DUF3450 PF11932.8 ORX46340.1 - 3.6 6.8 13.0 6.6 6.0 13.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Occludin_ELL PF07303.13 ORX46340.1 - 3.6 8.4 10.2 1.9 9.3 4.1 2.2 1 1 1 2 2 2 0 Occludin homology domain YabA PF06156.13 ORX46340.1 - 3.8 8.2 13.0 2.8 8.6 6.4 2.3 1 1 1 2 2 2 0 Initiation control protein YabA HSP70 PF00012.20 ORX46340.1 - 4.1 5.5 9.9 5.7 5.0 9.9 1.1 1 0 0 1 1 1 0 Hsp70 protein Spectrin PF00435.21 ORX46340.1 - 4.3 7.9 14.2 18 5.9 7.1 2.7 2 1 1 3 3 2 0 Spectrin repeat YtxH PF12732.7 ORX46340.1 - 4.5 7.9 11.6 78 3.9 10.2 2.7 2 1 0 2 2 1 0 YtxH-like protein DUF2524 PF10732.9 ORX46340.1 - 5.2 7.4 9.8 5.7 7.3 6.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) Atg14 PF10186.9 ORX46340.1 - 6 5.9 9.3 9 5.3 9.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RecG_N PF17190.4 ORX46340.1 - 6.8 7.5 10.6 2.9 8.7 4.8 2.3 2 0 0 2 2 2 0 RecG N-terminal helical domain Allexi_40kDa PF05549.11 ORX46340.1 - 7.7 5.9 7.5 7.6 6.0 5.0 1.8 1 1 1 2 2 2 0 Allexivirus 40kDa protein YojJ PF10372.9 ORX46340.1 - 8.2 6.6 8.8 6.9 6.8 1.4 2.5 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF883 PF05957.13 ORX46340.1 - 8.4 7.1 6.5 11 6.7 0.5 2.7 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF883) ERO1 PF04137.15 ORX46341.1 - 1.8e-132 441.8 0.3 2.1e-132 441.6 0.3 1.0 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GTP_cyclohydro2 PF00925.20 ORX46342.1 - 2.8e-63 212.4 0.0 5.9e-63 211.3 0.0 1.5 1 1 0 1 1 1 1 GTP cyclohydrolase II ThiS PF02597.20 ORX46343.1 - 1.1e-14 54.8 0.0 1.3e-14 54.6 0.0 1.0 1 0 0 1 1 1 1 ThiS family PqqD PF05402.12 ORX46343.1 - 0.01 16.1 0.1 0.014 15.6 0.1 1.2 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) DAO_C PF16901.5 ORX46343.1 - 0.14 12.1 0.0 0.2 11.5 0.0 1.3 1 1 0 1 1 1 0 C-terminal domain of alpha-glycerophosphate oxidase G-patch PF01585.23 ORX46344.1 - 2.4e-09 36.9 2.6 5.1e-09 35.9 2.6 1.6 1 0 0 1 1 1 1 G-patch domain Ifi-6-16 PF06140.13 ORX46345.1 - 2.5e-09 36.9 24.4 2.9e-09 36.7 24.4 1.1 1 0 0 1 1 1 1 Interferon-induced 6-16 family zf-RVT PF13966.6 ORX46346.1 - 2.4e-08 34.5 4.3 4.7e-08 33.6 4.3 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase FIBP PF05427.11 ORX46347.1 - 0.029 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) FIBP PF05427.11 ORX46348.1 - 0.029 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) FIBP PF05427.11 ORX46349.1 - 0.029 13.7 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Acidic fibroblast growth factor binding (FIBP) Prolactin_RP PF15172.6 ORX46350.1 - 0.15 11.7 0.1 4.7 6.9 0.0 2.3 2 0 0 2 2 2 0 Prolactin-releasing peptide AAA_23 PF13476.6 ORX46471.1 - 1.5e-11 45.2 139.4 5.4e-06 27.1 84.3 7.6 1 1 1 2 2 2 1 AAA domain AAA_15 PF13175.6 ORX46471.1 - 1.3e-08 34.9 0.0 1.3e-08 34.9 0.0 5.3 1 1 2 4 4 4 2 AAA ATPase domain AAA_21 PF13304.6 ORX46471.1 - 1.1e-07 32.0 8.5 0.00029 20.7 0.1 3.9 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system Rad50_zn_hook PF04423.14 ORX46471.1 - 2.5e-07 30.4 0.0 2.5e-07 30.4 0.0 4.6 4 0 0 4 4 4 1 Rad50 zinc hook motif SMC_N PF02463.19 ORX46471.1 - 6.5e-07 29.0 0.0 6.5e-07 29.0 0.0 3.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ORX46471.1 - 9.6e-05 22.6 0.0 0.0004 20.6 0.0 2.2 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit NPV_P10 PF05531.12 ORX46471.1 - 0.029 14.8 1.0 0.029 14.8 1.0 10.8 7 5 5 12 12 12 0 Nucleopolyhedrovirus P10 protein AAA_29 PF13555.6 ORX46471.1 - 0.057 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 ORX46471.1 - 0.11 12.7 2.4 0.2 11.9 0.1 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_13 PF13166.6 ORX46471.1 - 0.6 8.7 0.0 0.029 13.0 15.2 7.3 2 1 6 8 8 8 0 AAA domain G-patch PF01585.23 ORX46472.1 - 1.6e-17 63.1 0.4 4.5e-17 61.7 0.4 1.8 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 ORX46472.1 - 1.8e-12 47.0 0.0 5e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 R3H domain G-patch_2 PF12656.7 ORX46472.1 - 5.9e-06 26.3 0.1 5.9e-06 26.3 0.1 3.1 3 0 0 3 3 3 1 G-patch domain RPN2_C PF18004.1 ORX46472.1 - 0.03 14.3 6.2 2.7 7.9 6.2 2.7 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Phage_HK97_TLTM PF06120.11 ORX46472.1 - 0.15 11.2 8.0 0.053 12.7 5.0 1.7 2 0 0 2 2 2 0 Tail length tape measure protein PGA2 PF07543.12 ORX46472.1 - 0.2 11.6 0.1 0.2 11.6 0.1 4.9 4 1 0 4 4 4 0 Protein trafficking PGA2 Peptidase_S49_N PF08496.10 ORX46472.1 - 3.6 7.6 8.6 10 6.1 8.6 1.8 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 ORX46472.1 - 9.6 5.9 8.9 26 4.5 8.9 1.7 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Diphthami_syn_2 PF01902.17 ORX46473.1 - 9.2e-27 94.0 0.0 1.1e-26 93.7 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase PC-Esterase PF13839.6 ORX46474.1 - 6.5e-06 26.1 0.6 5.1e-05 23.2 0.1 2.6 2 2 0 3 3 3 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Metallophos PF00149.28 ORX46475.1 - 1.9e-12 48.1 2.6 3e-12 47.5 2.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase NIR_SIR PF01077.22 ORX46475.1 - 0.11 12.0 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain RGS PF00615.19 ORX46476.1 - 4.1e-10 40.0 0.0 6.7e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Mog1 PF04603.12 ORX46477.1 - 1.9e-40 138.4 1.8 2.8e-40 137.9 1.8 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein RhoGAP PF00620.27 ORX46478.1 - 9.1e-30 103.5 0.1 1.5e-29 102.8 0.1 1.3 1 0 0 1 1 1 1 RhoGAP domain ELO PF01151.18 ORX46479.1 - 9.4e-56 189.1 26.9 1.1e-55 188.9 26.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Abhydrolase_9_N PF15420.6 ORX46479.1 - 0.079 13.0 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus CCSMST1 PF15013.6 ORX46479.1 - 1.3 9.2 7.4 2 8.6 0.9 2.8 1 1 1 2 2 2 0 CCSMST1 family COX14 PF14880.6 ORX46480.1 - 0.00057 19.7 0.2 0.00074 19.3 0.2 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c assembly DUF4133 PF13571.6 ORX46480.1 - 0.0036 17.6 0.0 0.004 17.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4133) DUF1279 PF06916.13 ORX46481.1 - 2.8e-15 56.6 0.0 3.8e-15 56.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) MFS_1 PF07690.16 ORX46482.1 - 2e-40 138.8 18.5 8.5e-29 100.6 0.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX46482.1 - 9.7e-29 100.5 11.6 1.3e-23 83.6 0.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF4538 PF15061.6 ORX46482.1 - 0.19 11.5 0.2 0.59 9.9 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4538) FTHFS PF01268.19 ORX46483.1 - 2.1e-259 861.4 0.1 3.1e-259 860.8 0.1 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 ORX46483.1 - 8.5e-67 223.4 2.6 8.5e-67 223.4 2.6 2.2 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 ORX46483.1 - 6e-39 132.9 2.1 1.2e-38 131.9 1.2 2.0 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain OCD_Mu_crystall PF02423.15 ORX46483.1 - 0.055 12.4 0.4 0.11 11.4 0.4 1.4 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family P34-Arc PF04045.14 ORX46485.1 - 1.2e-105 352.6 1.1 1.4e-105 352.3 1.1 1.0 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc Pkinase PF00069.25 ORX46486.1 - 2.8e-64 217.0 0.0 3.5e-64 216.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46486.1 - 5.5e-34 117.6 0.0 7.3e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX46486.1 - 3.1e-07 30.0 0.0 9.6e-07 28.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX46486.1 - 1.3e-05 24.2 0.1 2.1e-05 23.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX46486.1 - 0.0026 16.8 0.2 0.0044 16.0 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ORX46486.1 - 0.004 16.8 0.1 2.2 7.8 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ORX46486.1 - 0.0053 16.1 0.1 0.011 15.1 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX46486.1 - 0.022 14.7 0.2 0.039 13.9 0.2 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Globin PF00042.22 ORX46487.1 - 0.014 15.9 0.1 5.3 7.7 0.0 2.4 2 0 0 2 2 2 0 Globin Thiolase_N PF00108.23 ORX46488.1 - 2.7e-95 318.6 3.7 3.5e-95 318.3 3.7 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX46488.1 - 2.5e-40 136.9 4.3 1e-39 135.0 0.8 2.7 2 1 1 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX46488.1 - 2.6e-06 27.2 7.3 4.5e-05 23.2 0.3 2.8 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain 7TMR-HDED PF07697.11 ORX46488.1 - 0.031 14.4 0.1 0.056 13.6 0.1 1.4 1 0 0 1 1 1 0 7TM-HD extracellular PNKP_ligase PF16542.5 ORX46488.1 - 0.043 13.3 0.1 0.067 12.7 0.1 1.2 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain bZIP_1 PF00170.21 ORX46490.1 - 7.6e-12 45.1 15.8 1.9e-11 43.9 14.6 2.2 2 1 0 2 2 1 1 bZIP transcription factor PAP1 PF08601.10 ORX46490.1 - 1.7e-08 34.6 8.1 4.9e-08 33.1 0.0 2.1 1 1 1 2 2 2 1 Transcription factor PAP1 bZIP_2 PF07716.15 ORX46490.1 - 4.9e-06 26.5 13.6 0.00077 19.5 8.4 2.3 1 1 1 2 2 2 2 Basic region leucine zipper TolA_bind_tri PF16331.5 ORX46490.1 - 0.0018 18.3 2.9 0.0018 18.3 2.9 2.1 1 1 1 2 2 2 1 TolA binding protein trimerisation Dynactin_p22 PF07426.11 ORX46490.1 - 0.0036 17.2 1.5 0.012 15.5 0.9 2.0 2 0 0 2 2 2 1 Dynactin subunit p22 Jnk-SapK_ap_N PF09744.9 ORX46490.1 - 0.0047 17.1 14.1 0.0048 17.1 11.4 2.0 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 Lectin_N PF03954.14 ORX46490.1 - 0.0068 16.2 3.0 0.013 15.2 3.0 1.5 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain Fmp27_WPPW PF10359.9 ORX46490.1 - 0.0094 14.9 2.6 0.01 14.8 2.6 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Cnn_1N PF07989.11 ORX46490.1 - 0.013 15.7 5.7 0.02 15.0 4.6 1.9 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Herpes_UL6 PF01763.16 ORX46490.1 - 0.016 13.7 2.2 0.021 13.4 2.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Tropomyosin_1 PF12718.7 ORX46490.1 - 0.02 15.0 8.7 0.047 13.9 8.7 1.6 1 0 0 1 1 1 0 Tropomyosin like V_ATPase_I PF01496.19 ORX46490.1 - 0.037 12.0 1.4 0.031 12.2 1.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC-167 PF15188.6 ORX46490.1 - 0.04 14.3 9.0 0.18 12.1 9.0 2.1 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 TSC22 PF01166.18 ORX46490.1 - 0.05 13.9 1.9 0.92 9.9 2.0 2.8 2 1 0 2 2 2 0 TSC-22/dip/bun family HalX PF08663.10 ORX46490.1 - 0.057 13.7 2.5 1.5 9.2 1.5 2.5 1 1 1 2 2 2 0 HalX domain CdvA PF18822.1 ORX46490.1 - 0.07 13.0 6.1 0.14 12.0 6.1 1.5 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DUF3584 PF12128.8 ORX46490.1 - 0.091 10.3 7.5 0.12 9.9 7.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Unstab_antitox PF09720.10 ORX46490.1 - 0.11 12.6 0.6 5.2 7.2 0.2 2.5 2 0 0 2 2 2 0 Putative addiction module component Atg14 PF10186.9 ORX46490.1 - 0.15 11.1 5.2 0.2 10.7 5.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IFP_35_N PF07334.13 ORX46490.1 - 0.15 12.1 0.4 0.15 12.1 0.4 2.4 1 1 1 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus DUF2730 PF10805.8 ORX46490.1 - 0.38 10.9 4.2 0.9 9.7 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Phlebovirus_NSM PF07246.11 ORX46490.1 - 0.47 9.8 6.2 0.75 9.1 6.2 1.3 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Fzo_mitofusin PF04799.13 ORX46490.1 - 0.54 9.8 5.5 0.9 9.1 5.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region DUF1003 PF06210.11 ORX46490.1 - 0.73 10.0 8.2 1.3 9.1 6.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) EMP24_GP25L PF01105.24 ORX46490.1 - 0.78 9.6 4.8 6.2 6.7 4.8 2.1 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD AAA_32 PF13654.6 ORX46490.1 - 0.89 8.3 6.7 1.4 7.7 6.7 1.2 1 0 0 1 1 1 0 AAA domain DUF724 PF05266.14 ORX46490.1 - 0.97 9.2 9.0 2.1 8.1 9.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DIT1_PvcA PF05141.12 ORX46490.1 - 0.98 8.8 4.6 1.4 8.3 4.6 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein DUF4175 PF13779.6 ORX46490.1 - 1.1 7.1 8.3 1.3 6.9 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) HemX PF04375.14 ORX46490.1 - 1.1 8.4 9.8 1.6 8.0 9.8 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase APG6_N PF17675.1 ORX46490.1 - 1.2 9.7 11.3 1.9 9.0 11.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 ORX46490.1 - 1.2 8.6 7.5 1.8 8.0 7.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 ORX46490.1 - 1.3 9.2 8.2 3 8.0 8.2 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 ORX46490.1 - 1.7 7.1 6.3 2.8 6.4 6.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 ORX46490.1 - 2.6 8.1 11.8 4.8 7.2 11.8 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_Maf PF03131.17 ORX46490.1 - 2.7 8.6 12.5 5.1 7.7 11.2 2.0 1 1 1 2 2 2 0 bZIP Maf transcription factor DUF3552 PF12072.8 ORX46490.1 - 2.9 7.2 14.8 4.5 6.6 14.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF4337 PF14235.6 ORX46490.1 - 3 8.0 6.8 4.9 7.3 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF5349 PF17298.2 ORX46490.1 - 5.2 6.7 8.4 8.6 6.0 8.4 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5349) DivIC PF04977.15 ORX46490.1 - 6.8 6.5 10.4 3.8 7.4 0.4 2.3 1 1 1 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 ORX46490.1 - 9.6 5.4 7.1 13 5.1 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DHHC PF01529.20 ORX46491.1 - 3.1e-36 124.4 12.6 3.1e-36 124.4 12.6 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase FF PF01846.19 ORX46495.1 - 2.8e-33 113.8 14.2 3.5e-12 46.3 0.6 5.5 7 0 0 7 7 7 3 FF domain WW PF00397.26 ORX46495.1 - 1.8e-15 56.7 14.0 1.8e-07 31.1 4.7 2.7 2 0 0 2 2 2 2 WW domain NleF_casp_inhib PF16809.5 ORX46495.1 - 0.13 12.1 3.0 1.7 8.5 0.6 2.4 2 0 0 2 2 2 0 NleF caspase inhibitor ABC2_membrane_2 PF12679.7 ORX46495.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Glyco_hyd_101C PF17451.2 ORX46495.1 - 0.42 10.9 9.9 2 8.7 1.3 2.6 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain RhoGAP-FF1 PF16512.5 ORX46495.1 - 7.8 7.2 9.4 0.28 11.9 0.2 3.5 4 1 0 4 4 4 0 p190-A and -B Rho GAPs FF domain zf-RING_2 PF13639.6 ORX46496.1 - 1.7e-13 50.7 6.0 1.7e-13 50.7 6.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX46496.1 - 1.4e-10 40.8 7.1 1.4e-10 40.8 7.1 2.6 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX46496.1 - 2e-09 37.6 5.1 2e-09 37.6 5.1 2.5 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ORX46496.1 - 6.9e-09 35.3 5.1 6.9e-09 35.3 5.1 2.4 3 0 0 3 3 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX46496.1 - 4.8e-08 32.9 3.3 4.8e-08 32.9 3.3 2.7 3 0 0 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX46496.1 - 2.6e-07 30.4 6.3 2.6e-07 30.4 6.3 2.7 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX46496.1 - 4.6e-07 29.6 11.1 1.5e-06 28.0 4.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX46496.1 - 4.8e-07 29.6 14.0 2.2e-06 27.5 5.2 2.3 2 0 0 2 2 2 2 zinc-RING finger domain zinc_ribbon_9 PF14369.6 ORX46496.1 - 5.4e-07 29.8 2.7 5.4e-07 29.8 2.7 2.2 2 0 0 2 2 2 1 zinc-ribbon zf-ANAPC11 PF12861.7 ORX46496.1 - 1.8e-05 24.7 3.9 4.4e-05 23.5 3.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX46496.1 - 4.2e-05 23.1 3.6 4.2e-05 23.1 3.6 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ORX46496.1 - 0.00023 21.0 5.4 0.00023 21.0 5.4 2.3 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING-like PF08746.11 ORX46496.1 - 0.017 15.4 4.6 0.017 15.4 4.6 2.1 2 0 0 2 2 2 0 RING-like domain Vps39_2 PF10367.9 ORX46496.1 - 0.041 14.3 5.2 0.19 12.2 0.1 2.7 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 DZR PF12773.7 ORX46496.1 - 0.047 13.7 1.0 0.047 13.7 1.0 2.6 2 1 0 2 2 2 0 Double zinc ribbon HypA PF01155.19 ORX46496.1 - 0.053 13.5 7.4 1.1 9.3 0.6 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_6 PF14835.6 ORX46496.1 - 0.2 11.5 0.8 0.46 10.4 0.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein Tnp_zf-ribbon_2 PF13842.6 ORX46496.1 - 0.51 11.2 3.5 3.7 8.4 3.5 2.3 1 1 1 2 2 2 0 DDE_Tnp_1-like zinc-ribbon C1_1 PF00130.22 ORX46496.1 - 2.3 8.1 12.8 6.2 6.8 0.8 2.8 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_10 PF16685.5 ORX46496.1 - 2.4 8.3 9.0 0.67 10.1 3.3 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 PHD PF00628.29 ORX46496.1 - 2.5 8.1 17.5 0.22 11.4 6.7 3.1 2 1 2 4 4 4 0 PHD-finger ADK_lid PF05191.14 ORX46496.1 - 2.8 8.0 6.8 21 5.2 0.6 2.9 2 1 0 2 2 2 0 Adenylate kinase, active site lid C1_2 PF03107.16 ORX46496.1 - 3 8.2 9.9 0.93 9.9 0.7 3.1 3 0 0 3 3 3 0 C1 domain zf-C2HE PF16278.5 ORX46496.1 - 5.5 7.5 6.9 11 6.6 0.1 3.2 3 1 0 3 3 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc-ribbons_6 PF07191.12 ORX46496.1 - 6.1 6.9 12.3 3.7 7.6 1.3 2.8 2 1 0 2 2 2 0 zinc-ribbons RINGv PF12906.7 ORX46496.1 - 8.7 6.6 12.1 0.32 11.1 5.7 2.0 2 0 0 2 2 2 0 RING-variant domain Arrestin_C PF02752.22 ORX46497.1 - 6.3e-07 29.9 0.1 1.4e-06 28.8 0.1 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain GATA PF00320.27 ORX46498.1 - 1.5e-18 66.1 3.8 1.8e-18 65.8 3.8 1.2 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX46498.1 - 0.0078 15.7 0.6 0.0091 15.5 0.6 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding Vps36-NZF-N PF16988.5 ORX46498.1 - 0.018 14.4 0.5 0.024 14.0 0.5 1.5 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Auto_anti-p27 PF06677.12 ORX46498.1 - 0.08 13.1 0.9 0.1 12.8 0.9 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 ORX46498.1 - 0.082 13.0 0.3 0.1 12.7 0.3 1.2 1 0 0 1 1 1 0 Zinc ribbon domain eIF-5_eIF-2B PF01873.17 ORX46498.1 - 0.12 12.2 0.7 0.15 11.9 0.7 1.2 1 0 0 1 1 1 0 Domain found in IF2B/IF5 zinc_ribbon_2 PF13240.6 ORX46498.1 - 0.72 9.6 5.7 7.5 6.4 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Hamartin PF04388.12 ORX46499.1 - 7.6e-20 71.2 33.4 1.1e-18 67.4 33.4 2.9 1 1 0 1 1 1 1 Hamartin protein DHR10 PF18595.1 ORX46499.1 - 5.1e-06 26.5 9.2 5.1e-06 26.5 9.2 3.8 3 0 0 3 3 3 1 Designed helical repeat protein 10 domain DUF4201 PF13870.6 ORX46499.1 - 0.0072 16.1 4.6 0.0072 16.1 4.6 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) Bcr-Abl_Oligo PF09036.10 ORX46499.1 - 0.32 11.0 2.6 2.1 8.4 0.3 2.9 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF948 PF06103.11 ORX46499.1 - 0.32 11.3 9.6 0.66 10.3 0.0 4.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Csm1_N PF18504.1 ORX46499.1 - 3.1 8.2 23.8 1.9 8.9 0.1 5.3 4 1 0 4 4 4 0 Csm1 N-terminal domain Isochorismatase PF00857.20 ORX46500.1 - 1.5e-30 106.7 0.1 1.9e-30 106.3 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family Sod_Cu PF00080.20 ORX46501.1 - 1.6e-40 138.6 5.0 2e-40 138.3 5.0 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) EamA PF00892.20 ORX46502.1 - 1.4e-13 51.2 22.0 1.7e-07 31.5 2.9 2.8 3 0 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX46502.1 - 9.2e-11 41.5 1.5 9.2e-11 41.5 1.5 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 ORX46502.1 - 3e-10 39.8 10.5 4.3e-10 39.3 10.5 1.2 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 ORX46502.1 - 1.2e-08 34.7 9.9 4.3e-05 23.0 0.6 2.2 1 1 1 2 2 2 2 Triose-phosphate Transporter family CRT-like PF08627.10 ORX46502.1 - 2.3e-07 30.1 13.0 3e-06 26.4 1.9 3.2 3 1 0 3 3 3 2 CRT-like, chloroquine-resistance transporter-like Bax1-I PF01027.20 ORX46502.1 - 5.9e-05 23.0 8.8 5.9e-05 23.0 8.8 2.4 1 1 1 2 2 2 1 Inhibitor of apoptosis-promoting Bax1 PUNUT PF16913.5 ORX46502.1 - 0.0047 16.2 4.0 0.0047 16.2 4.0 2.6 2 1 1 3 3 3 1 Purine nucleobase transmembrane transport SLC35F PF06027.12 ORX46502.1 - 0.024 14.2 17.0 0.14 11.7 17.0 2.3 1 1 0 1 1 1 0 Solute carrier family 35 TMEM234 PF10639.9 ORX46502.1 - 0.11 12.6 3.6 0.48 10.5 0.2 2.5 2 0 0 2 2 2 0 Putative transmembrane family 234 DUF1129 PF06570.11 ORX46502.1 - 1.5 8.3 0.0 1.5 8.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) TFIID-31kDa PF02291.15 ORX46504.1 - 4.4e-48 162.4 0.0 5.7e-48 162.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX46504.1 - 1.3e-06 28.3 0.0 2.3e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated Histone PF00125.24 ORX46504.1 - 4.2e-06 27.1 0.4 6.7e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX46504.1 - 0.00018 21.8 0.1 0.00026 21.3 0.1 1.2 1 0 0 1 1 1 1 CENP-S protein TFIID_30kDa PF03540.13 ORX46504.1 - 0.00043 20.2 0.5 0.0012 18.8 0.1 1.8 2 0 0 2 2 2 1 Transcription initiation factor TFIID 23-30kDa subunit CENP-T_C PF15511.6 ORX46504.1 - 0.0078 16.3 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX46504.1 - 0.04 14.1 0.0 0.063 13.5 0.0 1.3 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) TFIID_20kDa PF03847.13 ORX46504.1 - 0.14 12.7 0.1 0.3 11.6 0.1 1.5 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Sulfotransfer_3 PF13469.6 ORX46507.1 - 4e-09 37.2 9.3 1.8e-06 28.5 0.2 3.4 3 0 0 3 3 3 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 ORX46507.1 - 1e-05 25.2 3.5 3.5e-05 23.4 3.4 2.0 1 1 0 1 1 1 1 Sulfotransferase domain SUIM_assoc PF16619.5 ORX46507.1 - 0.08 13.0 12.4 0.047 13.8 5.2 2.8 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 ORX46507.1 - 1.1 9.2 8.5 0.61 10.0 6.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NADH-u_ox-rdase PF10785.9 ORX46508.1 - 9.1e-33 112.8 0.1 1.3e-32 112.3 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 ORX46508.1 - 3.8e-17 62.0 0.1 5.4e-17 61.5 0.1 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit Peptidase_M28 PF04389.17 ORX46509.1 - 3.1e-41 141.2 0.1 4.6e-41 140.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M42 PF05343.14 ORX46509.1 - 0.00054 19.1 0.0 0.0027 16.8 0.0 1.9 2 0 0 2 2 2 1 M42 glutamyl aminopeptidase DUF4131 PF13567.6 ORX46509.1 - 0.0058 16.3 1.0 0.0058 16.3 1.0 4.6 4 1 1 5 5 5 1 Domain of unknown function (DUF4131) Peptidase_M20 PF01546.28 ORX46509.1 - 0.0077 15.9 0.0 0.028 14.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 MRG PF05712.13 ORX46510.1 - 1.6e-31 109.2 1.5 2.9e-31 108.3 1.5 1.4 1 1 0 1 1 1 1 MRG Trehalose_PPase PF02358.16 ORX46511.1 - 2.1e-61 207.0 0.0 3.2e-61 206.4 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase DUF2811 PF10929.8 ORX46511.1 - 0.098 12.9 0.3 0.66 10.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2811) Glyco_hydro_18 PF00704.28 ORX46512.1 - 3.3e-24 86.2 1.0 1.2e-23 84.4 1.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_5_12_2 PF14600.6 ORX46512.1 - 0.032 14.1 21.3 0.16 12.0 2.5 3.6 3 0 0 3 3 3 0 Cellulose-binding domain CBM_5_12 PF02839.14 ORX46512.1 - 0.4 11.3 17.1 0.26 12.0 3.0 3.6 3 0 0 3 3 3 0 Carbohydrate binding domain Myb_DNA-binding PF00249.31 ORX46514.1 - 1.3e-53 179.0 25.6 1.7e-13 50.5 1.0 5.9 5 1 0 5 5 5 5 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX46514.1 - 1.1e-45 153.6 18.4 1.2e-13 51.1 0.1 5.8 2 1 4 6 6 6 5 Myb-like DNA-binding domain SLIDE PF09111.10 ORX46514.1 - 2.8e-09 37.0 0.7 0.69 10.0 0.0 4.8 3 2 2 5 5 5 3 SLIDE Myb_DNA-bind_7 PF15963.5 ORX46514.1 - 0.00017 21.4 0.2 18 5.3 0.0 5.2 4 1 1 5 5 5 0 Myb DNA-binding like Rap1_C PF11626.8 ORX46514.1 - 0.027 14.6 4.5 0.2 11.7 0.2 3.4 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_2 PF08914.11 ORX46514.1 - 0.033 14.4 0.0 11 6.3 0.0 3.3 2 1 1 3 3 3 0 Rap1 Myb domain SANT_DAMP1_like PF16282.5 ORX46514.1 - 0.11 12.8 8.3 0.25 11.6 0.0 4.4 4 1 1 5 5 5 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_5 PF13873.6 ORX46514.1 - 0.12 12.5 8.1 2.9 8.0 1.6 4.0 3 1 0 3 3 3 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 ORX46514.1 - 3.9 7.8 7.2 26 5.2 0.3 4.2 4 1 1 5 5 5 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 ORX46514.1 - 5.8 7.4 14.7 2.3 8.7 0.5 4.8 4 2 0 5 5 5 0 Myb/SANT-like DNA-binding domain NDC10_II PF16787.5 ORX46515.1 - 4.1e-10 39.2 0.0 8.1e-10 38.2 0.0 1.4 1 1 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 Dioxygenase_C PF00775.21 ORX46515.1 - 0.05 13.0 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase Bromodomain PF00439.25 ORX46516.1 - 2.6e-16 59.5 0.0 6.5e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Bromodomain Pkinase PF00069.25 ORX46516.1 - 8e-16 58.2 3.9 1.7e-08 34.2 1.9 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46516.1 - 2.9e-08 33.3 4.9 0.00037 19.9 4.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ORX46516.1 - 0.0017 17.8 0.5 0.0032 16.8 0.5 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX46516.1 - 0.057 13.0 0.3 0.14 11.8 0.3 1.6 1 0 0 1 1 1 0 RIO1 family Sec7 PF01369.20 ORX46517.1 - 1.3e-28 99.9 0.0 3.3e-27 95.3 0.0 2.2 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 ORX46517.1 - 1.3e-05 25.6 1.7 3.5e-05 24.2 1.7 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain HLH PF00010.26 ORX46519.1 - 7.6e-15 54.6 0.2 1.6e-14 53.6 0.2 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TFIIA PF03153.13 ORX46519.1 - 5.1 7.0 8.1 7.4 6.5 8.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit adh_short PF00106.25 ORX46520.1 - 1.7e-44 151.6 0.1 2.1e-43 148.1 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX46520.1 - 4.3e-28 98.5 0.2 4.2e-13 49.4 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX46520.1 - 6.6e-10 39.2 1.5 8e-08 32.4 0.3 2.3 1 1 1 2 2 2 2 KR domain Eno-Rase_NADH_b PF12242.8 ORX46520.1 - 0.011 15.5 0.0 0.025 14.4 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF5335 PF17269.2 ORX46520.1 - 0.067 13.0 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5335) DFP PF04127.15 ORX46520.1 - 0.15 11.9 0.0 0.39 10.5 0.0 1.6 1 1 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein Epimerase PF01370.21 ORX46520.1 - 0.16 11.4 0.1 0.31 10.5 0.1 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family DIOX_N PF14226.6 ORX46520.1 - 0.2 12.4 0.0 0.39 11.5 0.0 1.4 1 0 0 1 1 1 0 non-haem dioxygenase in morphine synthesis N-terminal GATase_5 PF13507.6 ORX46521.1 - 2.6e-102 341.4 0.0 3.9e-102 340.8 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 ORX46521.1 - 1.6e-51 174.5 0.8 2e-31 109.2 0.0 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 ORX46521.1 - 2.1e-35 121.2 0.0 4.2e-35 120.2 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 ORX46521.1 - 4e-21 75.3 0.0 9.5e-21 74.1 0.0 1.7 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF2373 PF10180.9 ORX46521.1 - 0.041 13.7 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) zf-ANAPC11 PF12861.7 ORX46522.1 - 3.2e-33 113.6 11.7 3.5e-33 113.5 11.7 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ORX46522.1 - 5.5e-21 74.6 15.5 6.9e-21 74.3 15.5 1.1 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ORX46522.1 - 3.4e-06 27.3 19.3 0.00013 22.2 19.4 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX46522.1 - 0.0055 16.5 7.7 0.0055 16.5 7.7 3.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX46522.1 - 0.037 13.8 11.9 0.4 10.5 11.9 2.2 1 1 0 1 1 1 0 RING-like zinc finger Zn_ribbon_17 PF17120.5 ORX46522.1 - 0.048 13.3 6.4 0.048 13.3 6.4 2.4 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-Nse PF11789.8 ORX46522.1 - 0.064 13.1 5.8 0.09 12.6 5.8 1.3 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ORX46522.1 - 0.08 13.0 13.8 0.2 11.7 13.8 1.7 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX46522.1 - 0.26 11.2 19.3 2.8 7.9 19.3 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX46522.1 - 0.28 11.2 15.1 13 5.8 16.0 2.4 1 1 1 2 2 2 0 zinc-RING finger domain PCI PF01399.27 ORX46523.1 - 5.5e-22 78.3 0.9 3.9e-21 75.5 0.0 2.4 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 ORX46523.1 - 6.1e-18 64.6 6.0 1.8e-17 63.1 6.0 1.9 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain WD40 PF00400.32 ORX46524.1 - 1.3e-18 67.0 20.4 0.00022 21.9 0.2 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX46524.1 - 3e-07 30.7 9.5 0.042 14.1 0.3 4.2 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 ORX46524.1 - 0.00038 20.4 9.1 1.1 9.1 9.1 2.5 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term SH3_3 PF08239.11 ORX46524.1 - 0.079 13.3 2.5 2 8.8 0.1 3.7 4 0 0 4 4 4 0 Bacterial SH3 domain Glyco_hydro_61 PF03443.14 ORX46524.1 - 5.2 6.9 8.3 1.1 9.2 0.7 2.3 1 1 1 2 2 2 0 Glycosyl hydrolase family 61 XG_FTase PF03254.13 ORX46525.1 - 2e-06 26.7 0.7 0.00031 19.5 0.0 2.8 2 2 2 4 4 4 2 Xyloglucan fucosyltransferase NodZ PF05830.11 ORX46525.1 - 0.0065 15.3 0.1 0.017 14.0 0.0 1.7 2 0 0 2 2 2 1 Nodulation protein Z (NodZ) DUF2615 PF11027.8 ORX46525.1 - 0.084 13.0 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) PMT PF02366.18 ORX46526.1 - 9.7e-81 270.9 16.1 1.7e-80 270.1 16.1 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX46526.1 - 2.5e-55 187.2 11.3 2.5e-55 187.2 11.3 2.5 2 1 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX46526.1 - 3.1e-18 66.3 0.0 6e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ORX46526.1 - 2.4e-06 27.8 11.8 2.4e-06 27.8 11.8 2.5 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase RIH_assoc PF08454.11 ORX46527.1 - 1.1e-21 76.6 8.5 3e-21 75.1 2.3 4.5 3 0 0 3 3 3 1 RyR and IP3R Homology associated Ins145_P3_rec PF08709.11 ORX46527.1 - 2.4e-17 62.9 0.0 2.4e-13 49.8 0.0 2.5 2 0 0 2 2 2 2 Inositol 1,4,5-trisphosphate/ryanodine receptor MIR PF02815.19 ORX46527.1 - 7.8e-12 45.4 0.0 7.2e-11 42.3 0.0 2.4 2 0 0 2 2 2 1 MIR domain RYDR_ITPR PF01365.21 ORX46527.1 - 1.2e-07 31.4 9.6 0.00032 20.2 5.2 4.0 2 1 1 3 3 3 2 RIH domain Ion_trans PF00520.31 ORX46527.1 - 0.00019 20.8 7.8 0.00019 20.8 7.8 2.8 3 1 0 3 3 3 1 Ion transport protein PT PF04886.12 ORX46529.1 - 1.2e-15 56.8 55.8 9.2e-05 21.9 6.3 9.9 4 1 4 8 8 8 5 PT repeat Mss4 PF04421.13 ORX46530.1 - 3.3e-24 84.9 0.0 4.1e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Mss4 protein FAD_binding_1 PF00667.20 ORX46531.1 - 5.3e-38 130.8 0.0 7.4e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX46531.1 - 1.9e-34 118.9 0.0 3.6e-34 118.0 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX46531.1 - 3.9e-14 53.2 0.0 9.5e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PqqD PF05402.12 ORX46531.1 - 0.0052 17.1 0.0 8.6 6.7 0.0 3.3 4 0 0 4 4 4 2 Coenzyme PQQ synthesis protein D (PqqD) Flavodoxin_5 PF12724.7 ORX46531.1 - 0.052 13.8 0.1 6.5 7.0 0.0 3.2 3 1 1 4 4 4 0 Flavodoxin domain EPL1 PF10513.9 ORX46532.1 - 4.2e-19 69.5 1.2 4.2e-19 69.5 1.2 2.0 2 1 0 2 2 2 1 Enhancer of polycomb-like Rtt106 PF08512.12 ORX46533.1 - 3.4e-28 97.9 0.1 1.3e-27 96.0 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like POB3_N PF17292.2 ORX46533.1 - 1.3e-26 92.8 0.7 9.2e-24 83.7 0.6 2.4 2 0 0 2 2 2 2 POB3-like N-terminal PH domain SSrecog PF03531.14 ORX46533.1 - 1.3e-18 66.7 0.0 8.5e-18 64.0 0.0 2.3 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) Glyco_hydro_18 PF00704.28 ORX46534.1 - 1.5e-21 77.5 0.8 9.5e-21 74.8 0.7 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX46534.1 - 4e-08 33.1 14.7 4e-08 33.1 14.7 4.0 2 2 1 3 3 3 1 Carbohydrate binding domain (family 19) zf-RVT PF13966.6 ORX46535.1 - 0.0041 17.8 0.0 0.0091 16.7 0.0 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase KLRAQ PF10205.9 ORX46536.1 - 1.8e-17 63.4 8.7 1.8e-17 63.4 8.7 2.5 1 1 1 2 2 1 1 Predicted coiled-coil domain-containing protein TMF_TATA_bd PF12325.8 ORX46536.1 - 0.00029 21.1 22.9 0.00034 20.8 6.1 2.7 1 1 2 3 3 3 1 TATA element modulatory factor 1 TATA binding KAR9 PF08580.10 ORX46536.1 - 0.00079 18.1 0.6 0.00079 18.1 0.6 2.1 2 0 0 2 2 2 1 Yeast cortical protein KAR9 Effector_1 PF04518.12 ORX46536.1 - 0.0015 17.8 6.2 0.0015 17.8 6.2 1.7 1 1 1 2 2 2 1 Effector from type III secretion system DUF1664 PF07889.12 ORX46536.1 - 0.0029 17.6 16.5 0.0092 16.0 2.8 3.4 1 1 1 3 3 3 2 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 ORX46536.1 - 0.011 15.8 0.5 0.011 15.8 0.5 3.3 2 2 1 3 3 3 0 TolA binding protein trimerisation Filament PF00038.21 ORX46536.1 - 0.011 15.3 20.3 0.023 14.3 9.4 2.6 2 1 0 2 2 2 0 Intermediate filament protein JIP_LZII PF16471.5 ORX46536.1 - 0.014 15.6 3.4 0.014 15.6 3.4 4.1 2 2 2 4 4 4 0 JNK-interacting protein leucine zipper II Prominin PF05478.11 ORX46536.1 - 0.023 12.7 13.3 0.029 12.4 13.3 1.2 1 0 0 1 1 1 0 Prominin Golgin_A5 PF09787.9 ORX46536.1 - 0.031 13.7 23.7 0.42 10.0 13.7 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 AIP3 PF03915.13 ORX46536.1 - 0.035 13.2 16.3 0.082 12.0 16.3 1.6 1 1 0 1 1 1 0 Actin interacting protein 3 GAS PF13851.6 ORX46536.1 - 0.062 12.6 28.3 0.12 11.7 14.1 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 ORX46536.1 - 0.073 12.9 28.8 0.38 10.6 22.9 2.5 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Nas2_N PF18265.1 ORX46536.1 - 0.098 12.6 8.4 0.86 9.6 0.0 4.2 4 0 0 4 4 4 0 Nas2 N_terminal domain Spc7 PF08317.11 ORX46536.1 - 0.11 11.3 26.8 0.14 11.0 14.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein YabA PF06156.13 ORX46536.1 - 0.16 12.6 25.3 1.4 9.6 2.3 3.6 1 1 1 3 3 3 0 Initiation control protein YabA MbeD_MobD PF04899.12 ORX46536.1 - 0.19 11.9 8.6 0.22 11.6 0.2 3.3 2 2 1 3 3 3 0 MbeD/MobD like AAA_13 PF13166.6 ORX46536.1 - 0.2 10.3 21.4 0.21 10.2 3.4 2.3 1 1 1 2 2 2 0 AAA domain Csm1_N PF18504.1 ORX46536.1 - 0.25 11.7 20.4 0.13 12.6 2.1 3.5 2 1 1 3 3 3 0 Csm1 N-terminal domain ATG16 PF08614.11 ORX46536.1 - 0.27 11.5 25.5 9.5 6.4 25.5 3.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) HOOK PF05622.12 ORX46536.1 - 0.32 9.1 25.0 2 6.5 10.5 2.0 1 1 1 2 2 2 0 HOOK protein Seryl_tRNA_N PF02403.22 ORX46536.1 - 0.34 11.2 22.2 0.92 9.8 8.0 3.1 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CorA PF01544.18 ORX46536.1 - 0.36 10.1 6.3 0.42 9.9 5.4 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DivIC PF04977.15 ORX46536.1 - 0.46 10.3 28.1 0.66 9.8 1.2 5.0 2 2 3 5 5 5 0 Septum formation initiator Taxilin PF09728.9 ORX46536.1 - 0.55 9.4 27.1 8 5.5 27.2 2.2 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DUF4407 PF14362.6 ORX46536.1 - 0.77 9.1 12.3 4 6.7 12.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 ORX46536.1 - 1.1 9.2 28.1 2 8.4 3.2 4.4 1 1 2 4 4 4 0 Prefoldin subunit Baculo_PEP_C PF04513.12 ORX46536.1 - 1.2 9.2 9.6 2.5 8.1 4.2 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF2968 PF11180.8 ORX46536.1 - 1.2 8.8 15.7 0.2 11.3 2.9 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2968) FlaC_arch PF05377.11 ORX46536.1 - 1.3 9.5 20.9 2.5 8.5 1.1 4.6 3 1 2 5 5 4 0 Flagella accessory protein C (FlaC) TFR_dimer PF04253.15 ORX46536.1 - 1.4 9.0 6.1 2.4 8.3 0.0 3.2 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain PRKG1_interact PF15898.5 ORX46536.1 - 1.4 9.8 21.1 13 6.7 7.8 3.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TSC22 PF01166.18 ORX46536.1 - 1.6 9.1 15.4 0.11 12.8 2.0 4.1 2 2 4 6 6 5 0 TSC-22/dip/bun family DUF4200 PF13863.6 ORX46536.1 - 1.6 9.1 27.5 13 6.2 5.1 3.6 2 2 0 2 2 2 0 Domain of unknown function (DUF4200) DUF641 PF04859.12 ORX46536.1 - 2 8.8 20.6 1.4 9.3 2.5 2.9 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) GOLGA2L5 PF15070.6 ORX46536.1 - 2.2 6.8 23.8 0.71 8.5 3.8 2.9 1 1 2 3 3 3 0 Putative golgin subfamily A member 2-like protein 5 NPV_P10 PF05531.12 ORX46536.1 - 2.7 8.5 13.7 9.1 6.8 0.2 3.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 ORX46536.1 - 2.7 8.2 29.4 1.9 8.6 17.4 3.2 1 1 1 2 2 2 0 Tropomyosin like Fib_alpha PF08702.10 ORX46536.1 - 2.7 8.2 20.6 0.34 11.1 2.2 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 ORX46536.1 - 3 7.1 23.4 2.7 7.2 6.1 3.6 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) DHR10 PF18595.1 ORX46536.1 - 3 7.9 29.6 1.1 9.4 14.8 3.3 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain Fez1 PF06818.15 ORX46536.1 - 3.7 8.0 21.9 1.9e+02 2.3 21.7 2.1 1 1 0 1 1 1 0 Fez1 DUF1515 PF07439.11 ORX46536.1 - 3.8 7.6 9.1 9.5 6.3 0.9 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1515) Lectin_N PF03954.14 ORX46536.1 - 4.5 7.0 16.3 0.35 10.6 0.6 3.2 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain TPR_MLP1_2 PF07926.12 ORX46536.1 - 5.8 7.0 32.4 5.1 7.2 5.7 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein MerR-DNA-bind PF09278.11 ORX46536.1 - 6.3 7.4 13.3 11 6.6 0.2 3.9 4 0 0 4 4 4 0 MerR, DNA binding HALZ PF02183.18 ORX46536.1 - 8.6 6.7 30.7 0.38 11.0 1.7 6.1 4 2 1 5 5 5 0 Homeobox associated leucine zipper PspB PF06667.12 ORX46536.1 - 9.6 6.4 7.9 14 5.8 1.7 3.1 2 1 1 3 3 3 0 Phage shock protein B KLRAQ PF10205.9 ORX46538.1 - 5.7e-17 61.8 7.8 5.7e-17 61.8 7.8 6.9 2 2 3 6 6 5 1 Predicted coiled-coil domain-containing protein TTKRSYEDQ PF10212.9 ORX46538.1 - 1.2e-10 41.0 10.5 1.2e-10 41.0 10.5 3.8 1 1 0 3 3 3 1 Predicted coiled-coil domain-containing protein Filament PF00038.21 ORX46538.1 - 2.2e-05 24.2 33.6 2.2e-05 24.2 33.6 4.3 3 1 1 4 4 4 2 Intermediate filament protein ZapB PF06005.12 ORX46538.1 - 0.0015 18.9 5.6 0.0015 18.9 5.6 9.5 4 3 4 8 8 8 2 Cell division protein ZapB TMF_TATA_bd PF12325.8 ORX46538.1 - 0.0018 18.5 5.8 0.0018 18.5 5.8 6.7 3 3 3 6 6 6 3 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 ORX46538.1 - 0.002 17.1 80.3 0.0023 16.9 16.5 5.2 4 1 1 5 5 5 3 Spc7 kinetochore protein DUF1664 PF07889.12 ORX46538.1 - 0.0026 17.8 55.2 0.057 13.5 3.1 6.9 3 1 2 6 6 6 4 Protein of unknown function (DUF1664) TMF_DNA_bd PF12329.8 ORX46538.1 - 0.0048 16.9 2.7 0.0048 16.9 2.7 9.6 5 4 3 9 9 8 1 TATA element modulatory factor 1 DNA binding Rootletin PF15035.6 ORX46538.1 - 0.0096 16.0 16.1 0.0096 16.0 16.1 4.6 1 1 4 5 5 5 1 Ciliary rootlet component, centrosome cohesion TolA_bind_tri PF16331.5 ORX46538.1 - 0.04 14.0 0.2 0.04 14.0 0.2 8.1 4 2 3 8 8 8 0 TolA binding protein trimerisation KASH_CCD PF14662.6 ORX46538.1 - 0.21 11.4 85.7 4.4 7.1 22.1 5.7 2 2 3 5 5 5 0 Coiled-coil region of CCDC155 or KASH DUF2935 PF11155.8 ORX46538.1 - 0.23 11.8 14.0 7.7 6.9 1.0 5.4 1 1 2 4 4 4 0 Domain of unknown function (DUF2935) GAS PF13851.6 ORX46538.1 - 0.23 10.8 82.6 0.12 11.7 19.1 5.6 3 1 2 5 5 5 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 ORX46538.1 - 0.4 10.9 92.1 0.56 10.4 2.3 6.0 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 ORX46538.1 - 0.51 8.9 70.1 0.22 10.1 18.9 5.0 2 1 3 5 5 5 0 AAA domain Tropomyosin_1 PF12718.7 ORX46538.1 - 0.55 10.4 84.3 0.19 11.9 13.4 6.4 2 1 2 5 5 4 0 Tropomyosin like Myb_DNA-bind_4 PF13837.6 ORX46538.1 - 0.56 10.6 3.9 4 7.9 0.2 3.6 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain FUSC PF04632.12 ORX46538.1 - 0.71 8.3 25.1 0.27 9.7 11.5 3.2 3 1 0 3 3 3 0 Fusaric acid resistance protein family UPF0242 PF06785.11 ORX46538.1 - 2.7 8.0 85.0 0.24 11.5 7.1 5.7 2 1 3 5 5 5 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 ORX46538.1 - 3.3 8.4 71.3 1.6 9.4 3.5 8.5 2 1 5 8 8 8 0 Initiation control protein YabA Fib_alpha PF08702.10 ORX46538.1 - 5.2 7.3 63.4 0.045 13.9 2.2 5.6 4 1 1 5 5 5 0 Fibrinogen alpha/beta chain family Myb_DNA-binding PF00249.31 ORX46539.1 - 1.2e-56 188.7 21.3 6.8e-09 35.8 0.2 9.6 9 1 0 9 9 9 9 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX46539.1 - 5.8e-50 167.4 10.3 1.5e-09 38.0 0.0 9.4 5 3 4 9 9 9 9 Myb-like DNA-binding domain Myb_DNA-bind_4 PF13837.6 ORX46539.1 - 1.5e-05 25.3 9.9 0.0001 22.6 0.0 5.5 7 0 0 7 7 7 1 Myb/SANT-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX46539.1 - 1.6e-05 24.7 1.5 2 8.4 0.0 5.3 5 0 0 5 5 5 2 Myb DNA-binding like Imm51 PF15595.6 ORX46539.1 - 0.0016 18.3 0.1 18 5.4 0.0 3.8 4 0 0 4 4 4 2 Immunity protein 51 Ribosomal_L6e PF01159.19 ORX46540.1 - 1.1e-34 119.3 2.4 1.1e-34 119.3 2.4 1.6 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 ORX46540.1 - 1.4e-10 41.2 0.5 1.4e-10 41.2 0.5 3.0 3 1 0 3 3 3 1 Ribosomal protein L6, N-terminal domain KOW PF00467.29 ORX46540.1 - 0.043 13.8 1.8 0.046 13.7 0.1 1.9 2 0 0 2 2 2 0 KOW motif Apc13p PF05839.11 ORX46541.1 - 4.9e-09 36.2 0.8 5.6e-09 36.1 0.8 1.0 1 0 0 1 1 1 1 Apc13p protein Myb_DNA-bind_6 PF13921.6 ORX46542.1 - 0.00027 21.1 0.0 0.0005 20.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX46542.1 - 0.0003 20.9 0.0 0.00038 20.6 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3844 PF12955.7 ORX46543.1 - 0.0015 18.6 0.1 0.003 17.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) KinB_sensor PF16767.5 ORX46543.1 - 0.025 15.0 0.7 0.04 14.4 0.7 1.3 1 0 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB MRP-L46 PF11788.8 ORX46544.1 - 1.2e-17 64.7 2.7 1.3e-17 64.7 0.5 2.1 1 1 1 2 2 2 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 ORX46544.1 - 0.00024 21.1 0.0 0.00049 20.1 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain DUF687 PF05095.12 ORX46545.1 - 0.19 10.2 0.4 0.27 9.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF687) CENP-H PF05837.12 ORX46545.1 - 2.9 8.3 20.4 1.3 9.4 7.2 2.8 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF724 PF05266.14 ORX46545.1 - 3.8 7.3 17.9 2.3 8.0 8.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TPR_MLP1_2 PF07926.12 ORX46545.1 - 7.6 6.6 28.5 0.15 12.1 9.8 2.7 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ETF PF01012.21 ORX46546.1 - 1.5e-47 161.8 3.5 2e-47 161.5 3.5 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain SBP_bac_8 PF13416.6 ORX46546.1 - 0.0019 18.0 0.3 0.003 17.4 0.3 1.3 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein HMA PF00403.26 ORX46547.1 - 7.5e-54 180.0 7.1 1.1e-15 57.8 0.4 4.6 4 0 0 4 4 4 4 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 ORX46547.1 - 2e-40 138.2 1.9 2e-40 138.2 1.9 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX46547.1 - 4.3e-39 135.0 0.1 7.9e-39 134.1 0.1 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX46547.1 - 5.9e-06 26.2 2.7 0.00027 20.7 0.5 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX46547.1 - 8.3e-05 23.1 0.0 0.00043 20.7 0.0 2.1 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase FeS_assembly_P PF01883.19 ORX46547.1 - 0.025 14.8 0.1 5 7.4 0.0 3.0 2 0 0 2 2 2 0 Iron-sulfur cluster assembly protein XPG_N PF00752.17 ORX46548.1 - 5e-32 110.4 0.0 1.5e-31 108.8 0.0 1.9 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ORX46548.1 - 1.9e-25 89.0 0.1 6.2e-25 87.4 0.1 2.0 1 0 0 1 1 1 1 XPG I-region Desmo_N PF06771.11 ORX46548.1 - 0.045 14.1 0.1 3.6 8.0 0.0 3.6 4 0 0 4 4 4 0 Viral Desmoplakin N-terminus 5_3_exonuc PF01367.20 ORX46548.1 - 0.11 13.1 0.0 0.79 10.4 0.0 2.4 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold Cation_efflux PF01545.21 ORX46549.1 - 3.2e-30 105.4 12.2 3.9e-30 105.1 12.2 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ORX46549.1 - 1e-13 51.2 0.0 2e-13 50.3 0.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter PH_9 PF15410.6 ORX46550.1 - 1.5e-09 38.2 0.0 3.5e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX46550.1 - 7.9e-07 29.6 0.1 6.4e-06 26.6 0.1 2.1 1 1 0 1 1 1 1 PH domain Linker_histone PF00538.19 ORX46551.1 - 7.4e-26 90.3 0.1 7.4e-26 90.3 0.1 1.9 2 0 0 2 2 2 1 linker histone H1 and H5 family CDC27 PF09507.10 ORX46551.1 - 1.4 8.2 34.2 2.2 7.6 34.2 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Mitofilin PF09731.9 ORX46551.1 - 1.7 7.4 24.5 1.7 7.4 24.5 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Rib_5-P_isom_A PF06026.14 ORX46552.1 - 7.4e-62 208.0 0.0 9.3e-62 207.7 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 ORX46552.1 - 0.013 15.5 0.0 0.51 10.3 0.0 2.2 1 1 1 2 2 2 0 DeoR C terminal sensor domain RRM_1 PF00076.22 ORX46553.1 - 1.9e-32 110.9 0.0 2.6e-10 40.0 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX46553.1 - 5.1e-17 61.5 0.1 4.4e-05 23.3 0.1 3.2 3 0 0 3 3 3 3 Occluded RNA-recognition motif RRM_3 PF08777.11 ORX46553.1 - 1.3e-05 25.2 0.1 0.003 17.6 0.0 3.1 3 0 0 3 3 3 1 RNA binding motif Limkain-b1 PF11608.8 ORX46553.1 - 5.4e-05 23.2 0.0 0.3 11.2 0.0 2.6 2 0 0 2 2 2 2 Limkain b1 RRM_5 PF13893.6 ORX46553.1 - 0.00013 21.5 2.3 0.19 11.3 0.2 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX46553.1 - 0.045 13.9 0.0 19 5.5 0.0 2.8 3 0 0 3 3 3 0 RNA recognition motif SET_assoc PF11767.8 ORX46553.1 - 0.053 13.2 0.0 4.6 7.0 0.0 3.0 3 1 0 3 3 3 0 Histone lysine methyltransferase SET associated RRM_Rrp7 PF17799.1 ORX46553.1 - 0.082 12.7 0.4 2 8.2 0.0 2.6 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain PHM7_cyt PF14703.6 ORX46553.1 - 0.084 13.1 2.2 1.8 8.8 0.4 2.9 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter SNF2_N PF00176.23 ORX46554.1 - 2.7e-56 190.8 0.0 5.7e-56 189.7 0.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX46554.1 - 2.2e-17 63.4 0.0 4.6e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ORX46554.1 - 2e-12 46.8 8.4 4.6e-10 39.2 1.7 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ORX46554.1 - 9.1e-05 22.5 0.0 0.00025 21.1 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 ORX46554.1 - 0.00029 21.1 0.1 0.00077 19.7 0.1 1.7 1 0 0 1 1 1 1 CHDCT2 (NUC038) domain UQ_con PF00179.26 ORX46555.1 - 4.7e-46 155.9 0.0 5.7e-46 155.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pmp3 PF01679.17 ORX46558.1 - 1.2e-22 79.9 8.6 1.4e-22 79.6 8.6 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF4134 PF13572.6 ORX46558.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4134) Whi5 PF08528.11 ORX46559.1 - 1.9e-08 33.7 0.1 3.4e-08 32.9 0.1 1.4 1 0 0 1 1 1 1 Whi5 like QWRF PF04484.12 ORX46559.1 - 0.24 11.1 6.2 0.31 10.7 6.2 1.1 1 0 0 1 1 1 0 QWRF family Histone PF00125.24 ORX46561.1 - 0.15 12.4 0.6 19 5.6 0.2 2.1 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 DUF1752 PF08550.10 ORX46562.1 - 2.3e-13 49.7 5.8 4e-13 48.9 5.8 1.4 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) START PF01852.19 ORX46563.1 - 5.3e-08 32.5 0.2 1.5e-06 27.8 0.0 2.5 2 0 0 2 2 2 1 START domain Glyco_hydro_5_C PF18564.1 ORX46563.1 - 0.013 16.0 0.1 0.052 14.1 0.0 2.1 2 0 0 2 2 2 0 Glycoside hydrolase family 5 C-terminal domain EKLF_TAD1 PF16832.5 ORX46563.1 - 0.2 11.6 1.2 0.44 10.5 1.2 1.5 1 0 0 1 1 1 0 Erythroid krueppel-like transcription factor, transactivation 1 Pet127 PF08634.10 ORX46564.1 - 1.9e-96 322.7 5.6 1.9e-96 322.7 5.6 1.7 2 0 0 2 2 2 1 Mitochondrial protein Pet127 Ribosomal_L31 PF01197.18 ORX46565.1 - 4.1e-06 26.9 0.0 7.5e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Ribosomal protein L31 Acyl_transf_1 PF00698.21 ORX46566.1 - 8.4e-27 94.5 0.1 1.2e-26 94.0 0.1 1.1 1 0 0 1 1 1 1 Acyl transferase domain SAT PF16073.5 ORX46566.1 - 0.00034 20.4 0.5 0.0015 18.3 0.5 1.9 1 1 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Abhydrolase_1 PF00561.20 ORX46569.1 - 2.9e-14 53.3 0.0 5.6e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX46569.1 - 3.5e-06 26.4 0.0 1.7e-05 24.2 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX46569.1 - 0.00062 20.4 0.0 0.0012 19.5 0.0 1.7 1 1 0 1 1 1 1 Alpha/beta hydrolase family Rhomboid PF01694.22 ORX46570.1 - 4.5e-33 114.4 10.2 4.5e-33 114.4 10.2 1.9 3 0 0 3 3 3 1 Rhomboid family DUF2177 PF09945.9 ORX46570.1 - 0.036 14.2 1.1 0.036 14.2 1.1 3.1 2 1 1 3 3 3 0 Predicted membrane protein (DUF2177) DUF5518 PF17647.1 ORX46570.1 - 5.8 7.1 16.3 0.14 12.4 4.1 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5518) Sod_Cu PF00080.20 ORX46571.1 - 9.9e-48 161.9 6.2 1.1e-47 161.7 6.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CHRD PF07452.12 ORX46571.1 - 0.023 15.7 2.3 0.099 13.6 1.5 1.9 1 1 1 2 2 2 0 CHRD domain Snapin_Pallidin PF14712.6 ORX46572.1 - 0.028 14.8 6.3 3.3 8.2 2.3 3.0 2 1 1 3 3 3 0 Snapin/Pallidin GIT_CC PF16559.5 ORX46572.1 - 0.1 12.4 4.5 3.4 7.6 0.4 2.9 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PDCD7 PF16021.5 ORX46572.1 - 0.51 9.4 9.1 3.2 6.8 9.2 2.1 2 1 0 2 2 2 0 Programmed cell death protein 7 NPV_P10 PF05531.12 ORX46572.1 - 2.1 8.9 5.6 18 5.9 1.5 3.6 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein UAF_Rrn10 PF05234.11 ORX46573.1 - 0.00025 21.3 0.0 0.00033 20.9 0.0 1.2 1 0 0 1 1 1 1 UAF complex subunit Rrn10 DUF1882 PF08966.11 ORX46573.1 - 0.056 13.7 0.1 0.077 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) Cofilin_ADF PF00241.20 ORX46574.1 - 2.8e-37 127.2 2.6 7.5e-21 74.2 0.4 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein Cyclin PF08613.11 ORX46575.1 - 2.2e-39 135.4 0.3 3.3e-39 134.8 0.3 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX46575.1 - 0.00015 21.5 0.0 0.00026 20.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain SUR7 PF06687.12 ORX46576.1 - 9e-12 45.1 17.2 1.3e-11 44.6 15.9 1.9 1 1 0 1 1 1 1 SUR7/PalI family Calici_coat_C PF08435.11 ORX46576.1 - 0.013 15.0 1.7 0.038 13.5 1.2 1.8 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal RCR PF12273.8 ORX46576.1 - 0.013 16.2 1.6 0.048 14.3 1.6 2.0 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red L_HMGIC_fpl PF10242.9 ORX46576.1 - 0.043 14.0 2.9 0.11 12.7 2.9 1.6 1 1 0 1 1 1 0 Lipoma HMGIC fusion partner-like protein CK2S PF15011.6 ORX46709.1 - 0.0065 16.4 1.8 3.2 7.6 0.0 2.8 3 0 0 3 3 3 2 Casein Kinase 2 substrate Metallophos PF00149.28 ORX46710.1 - 4.7e-10 40.3 2.2 6.6e-10 39.8 2.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Stomoxyn PF11585.8 ORX46711.1 - 0.0024 17.8 0.0 33 4.6 0.0 3.2 3 0 0 3 3 3 3 Insect antimicrobial peptide, stomoxyn TGT_C1 PF14809.6 ORX46711.1 - 0.0043 17.3 6.2 14 6.1 0.1 3.8 3 1 1 4 4 4 3 C1 domain of tRNA-guanine transglycosylase dimerisation PI-PLC-Y PF00387.19 ORX46711.1 - 0.02 15.2 1.6 50 4.3 0.1 3.2 3 0 0 3 3 3 0 Phosphatidylinositol-specific phospholipase C, Y domain Fungal_trans PF04082.18 ORX46712.1 - 4.2e-12 45.7 5.6 4.2e-12 45.7 5.6 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain WRKY PF03106.15 ORX46713.1 - 6.5e-10 39.1 1.6 1.3e-09 38.1 1.6 1.5 1 0 0 1 1 1 1 WRKY DNA -binding domain MOZ_SAS PF01853.18 ORX46714.1 - 7.3e-82 273.4 0.1 1.1e-81 272.7 0.1 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX46714.1 - 1.1e-23 82.6 4.9 1.1e-23 82.6 4.9 2.6 3 0 0 3 3 3 1 MYST family zinc finger domain Tudor-knot PF11717.8 ORX46714.1 - 3.1e-19 68.6 0.7 7.2e-19 67.4 0.7 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 ORX46714.1 - 0.04 14.4 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Aldedh PF00171.22 ORX46715.1 - 2.9e-177 589.9 0.0 3.3e-177 589.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Homez PF11569.8 ORX46716.1 - 0.011 15.1 0.1 0.061 12.8 0.1 2.0 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Aldedh PF00171.22 ORX46717.1 - 1.4e-186 620.6 0.3 1.6e-186 620.3 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family zf-RING_2 PF13639.6 ORX46718.1 - 5e-08 33.2 8.4 1.3e-07 31.9 8.4 1.8 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 ORX46718.1 - 2.5e-05 24.4 4.8 9.1e-05 22.6 4.8 2.0 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 ORX46718.1 - 0.00013 22.2 6.0 0.0004 20.6 6.0 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX46718.1 - 0.00015 21.8 1.6 0.00015 21.8 1.6 3.4 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ORX46718.1 - 0.0055 16.8 7.4 0.017 15.2 7.4 1.9 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.25 ORX46718.1 - 0.02 14.8 9.6 0.041 13.7 9.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX46718.1 - 0.043 13.7 7.6 0.11 12.4 7.6 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX46718.1 - 0.047 13.3 4.5 0.13 11.9 4.5 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_9 PF13901.6 ORX46718.1 - 0.065 13.2 1.9 0.2 11.6 1.9 1.9 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon zf-RING-like PF08746.11 ORX46718.1 - 0.085 13.2 7.7 0.18 12.1 7.7 1.6 1 0 0 1 1 1 0 RING-like domain C1_1 PF00130.22 ORX46718.1 - 0.23 11.3 8.7 0.021 14.7 2.2 2.6 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 ORX46718.1 - 0.38 10.7 6.2 0.92 9.4 6.2 1.7 1 0 0 1 1 1 0 PHD-finger zf-C3HC4_3 PF13920.6 ORX46718.1 - 3.1 7.7 6.0 7.3 6.5 6.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FAD_binding_3 PF01494.19 ORX46719.1 - 6e-61 206.6 0.0 3.6e-38 131.7 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 ORX46719.1 - 6.7e-07 28.8 0.0 3.5e-06 26.5 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX46719.1 - 1.3e-05 24.1 0.1 0.00037 19.3 0.0 2.4 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox PF00070.27 ORX46719.1 - 9.6e-05 22.9 0.0 0.36 11.4 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX46719.1 - 0.0016 18.1 0.0 0.0031 17.1 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ORX46719.1 - 0.0019 17.5 0.6 0.031 13.5 0.0 3.0 4 0 0 4 4 4 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX46719.1 - 0.0046 16.4 0.0 0.01 15.2 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX46719.1 - 0.015 15.5 0.0 0.063 13.5 0.0 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain XdhC_C PF13478.6 ORX46719.1 - 0.043 14.3 0.0 1.7 9.1 0.0 2.7 2 0 0 2 2 2 0 XdhC Rossmann domain FAD_binding_2 PF00890.24 ORX46719.1 - 0.058 12.5 0.0 0.095 11.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain TrkA_N PF02254.18 ORX46719.1 - 0.094 13.0 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain DUF4520 PF15016.6 ORX46719.1 - 0.12 12.5 0.0 0.37 10.9 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) Glu_dehyd_C PF16912.5 ORX46719.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.5 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 ORX46719.1 - 0.15 11.3 0.0 0.28 10.5 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ORX46719.1 - 0.19 10.9 0.0 0.4 9.9 0.0 1.5 1 0 0 1 1 1 0 Thi4 family C2 PF00168.30 ORX46720.1 - 2.3e-10 40.7 0.0 1.2e-09 38.4 0.0 2.1 2 0 0 2 2 2 1 C2 domain C2-C2_1 PF11618.8 ORX46720.1 - 0.02 15.0 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 First C2 domain of RPGR-interacting protein 1 SAPS PF04499.15 ORX46720.1 - 0.59 8.9 9.3 0.97 8.1 9.3 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Dsh_C PF12316.8 ORX46720.1 - 1 9.8 9.0 0.56 10.6 4.7 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Asp-B-Hydro_N PF05279.11 ORX46720.1 - 1.2 9.2 19.0 2 8.4 19.0 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region V_ATPase_I PF01496.19 ORX46720.1 - 2.8 5.7 11.3 4.5 5.1 11.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 ORX46720.1 - 9.6 5.9 13.0 20 4.9 13.0 1.6 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 ORX46721.1 - 5.8e-38 130.8 0.1 8.2e-38 130.3 0.1 1.2 1 0 0 1 1 1 1 Cytochrome P450 INT_SG_DDX_CT_C PF15300.6 ORX46721.1 - 0.0015 18.3 0.1 0.097 12.5 0.0 2.5 2 0 0 2 2 2 1 INTS6/SAGE1/DDX26B/CT45 C-terminus zf-C3HC4_5 PF17121.5 ORX46721.1 - 0.074 12.9 0.2 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4448 PF14610.6 ORX46722.1 - 0.0001 22.1 1.6 0.00012 21.9 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) SPRY PF00622.28 ORX46723.1 - 1.3e-15 57.5 0.0 1.9e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Endosulfine PF04667.17 ORX46724.1 - 1.3e-27 95.7 0.2 1.6e-27 95.4 0.2 1.1 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region NPDC1 PF06809.11 ORX46724.1 - 0.025 13.6 0.2 0.027 13.5 0.2 1.1 1 0 0 1 1 1 0 Neural proliferation differentiation control-1 protein (NPDC1) Methyltransf_25 PF13649.6 ORX46727.1 - 6.6e-15 55.6 0.0 1.1e-14 54.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX46727.1 - 1.4e-14 54.3 0.0 1.6e-14 54.1 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX46727.1 - 1.2e-12 48.3 0.0 1.8e-12 47.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX46727.1 - 2.3e-11 43.7 0.0 1.4e-10 41.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX46727.1 - 5.3e-11 43.1 0.0 1.1e-10 42.1 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX46727.1 - 1.4e-06 27.9 0.0 4.9e-05 22.9 0.0 2.4 1 1 2 3 3 3 1 Putative methyltransferase Ubie_methyltran PF01209.18 ORX46727.1 - 5.4e-06 25.9 0.0 8.8e-06 25.2 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 ORX46727.1 - 2e-05 24.0 0.0 2.6e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain CheR PF01739.18 ORX46727.1 - 0.00019 21.0 0.0 0.00032 20.2 0.0 1.3 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain DUF938 PF06080.12 ORX46727.1 - 0.0011 18.8 0.0 0.024 14.4 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_8 PF05148.15 ORX46727.1 - 0.002 18.0 0.0 0.0027 17.6 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 ORX46727.1 - 0.018 14.7 0.0 0.024 14.2 0.0 1.1 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW SmaI PF17411.2 ORX46727.1 - 0.12 11.6 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease HSP70 PF00012.20 ORX46728.1 - 0.00043 18.6 0.0 0.00096 17.5 0.0 1.6 2 0 0 2 2 2 1 Hsp70 protein PPC PF04151.15 ORX46728.1 - 0.13 13.4 0.0 0.96 10.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain Pkinase PF00069.25 ORX46729.1 - 9.1e-67 225.2 0.1 6.6e-66 222.4 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46729.1 - 7.8e-38 130.2 0.0 2.5e-37 128.6 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 ORX46729.1 - 2.9e-21 75.0 0.1 5.1e-21 74.2 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 ORX46729.1 - 5.7e-07 29.1 0.0 9.5e-07 28.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX46729.1 - 0.00013 22.0 3.6 0.0071 16.3 0.0 3.0 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX46729.1 - 0.00048 19.2 0.2 0.00048 19.2 0.2 2.3 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ORX46729.1 - 0.001 18.4 0.0 0.0026 17.1 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX46729.1 - 0.0097 15.5 0.1 0.023 14.3 0.1 1.6 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX46729.1 - 0.04 12.7 0.9 0.088 11.6 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Clathrin_H_link PF13838.6 ORX46729.1 - 0.23 11.4 0.3 0.52 10.3 0.3 1.6 1 0 0 1 1 1 0 Clathrin-H-link Nt_Gln_amidase PF09764.9 ORX46730.1 - 2.6e-64 216.2 0.1 2.9e-64 216.1 0.1 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase AA_permease_2 PF13520.6 ORX46731.1 - 1.9e-48 165.4 46.7 2.3e-48 165.1 46.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX46731.1 - 2.4e-14 52.8 38.9 3.1e-14 52.4 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease PALP PF00291.25 ORX46733.1 - 1.6e-74 250.9 0.1 1.9e-74 250.7 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3808 PF10300.9 ORX46734.1 - 1.5e-54 185.6 5.5 3.5e-54 184.3 2.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX46734.1 - 0.00011 22.0 1.5 0.38 11.0 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX46734.1 - 0.00019 22.0 0.6 6 8.0 0.2 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF485 PF04341.12 ORX46734.1 - 0.13 12.2 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF485 TPR_12 PF13424.6 ORX46734.1 - 0.14 12.5 0.2 5 7.5 0.0 3.3 2 1 1 3 3 3 0 Tetratricopeptide repeat CK2S PF15011.6 ORX46736.1 - 0.49 10.3 3.0 0.95 9.3 1.7 1.9 2 0 0 2 2 2 0 Casein Kinase 2 substrate CA_like PF10563.9 ORX46736.1 - 0.53 10.2 4.8 0.12 12.3 0.3 2.1 2 0 0 2 2 2 0 Putative carbonic anhydrase DUF948 PF06103.11 ORX46736.1 - 1.6 9.0 6.1 4.8 7.5 3.3 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spectrin PF00435.21 ORX46736.1 - 2.8 8.5 5.2 3.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Spectrin repeat SKA1 PF07160.12 ORX46736.1 - 3.1 7.6 6.0 5.8 6.7 1.9 2.8 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Metallophos PF00149.28 ORX46737.1 - 3.7e-12 47.2 1.1 1e-11 45.8 1.1 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX46737.1 - 0.0017 18.5 0.1 0.013 15.7 0.1 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2839 PF10999.8 ORX46738.1 - 0.079 13.3 2.1 0.63 10.4 1.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2839) Far-17a_AIG1 PF04750.14 ORX46738.1 - 1 8.7 25.7 2 7.7 25.7 1.6 1 1 0 1 1 1 0 FAR-17a/AIG1-like protein PRP3 PF08572.10 ORX46739.1 - 3.6e-70 236.2 9.5 3.6e-70 236.2 9.5 1.5 2 0 0 2 2 2 1 pre-mRNA processing factor 3 (PRP3) DUF733 PF05306.11 ORX46739.1 - 0.36 11.2 0.1 0.36 11.2 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF733) Ydc2-catalyt PF09159.10 ORX46740.1 - 3.4e-20 72.9 7.2 3.1e-10 40.3 0.2 3.1 2 1 1 3 3 3 3 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 SAP PF02037.27 ORX46740.1 - 0.00062 19.4 0.0 0.0012 18.5 0.0 1.5 1 0 0 1 1 1 1 SAP domain Pox_A22 PF04848.13 ORX46740.1 - 0.021 15.0 0.0 6.7 6.8 0.0 3.0 2 1 0 2 2 2 0 Poxvirus A22 protein DSPc PF00782.20 ORX46741.1 - 1.7e-28 99.0 0.0 2.2e-28 98.7 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ORX46741.1 - 0.00029 21.1 0.0 0.00049 20.4 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain EamA PF00892.20 ORX46742.1 - 8.1e-08 32.5 24.8 0.00083 19.5 2.7 3.2 3 0 0 3 3 3 3 EamA-like transporter family PUNUT PF16913.5 ORX46742.1 - 1.1e-06 28.2 0.3 2.2e-06 27.1 0.3 1.6 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport Nuc_sug_transp PF04142.15 ORX46742.1 - 7.5e-05 22.0 7.0 0.00012 21.3 7.0 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 ORX46742.1 - 0.071 12.4 9.9 0.36 10.1 9.3 2.6 2 1 0 2 2 2 0 Triose-phosphate Transporter family UAA PF08449.11 ORX46742.1 - 5 6.2 16.9 0.33 10.1 11.6 1.7 2 1 0 2 2 2 0 UAA transporter family Brr6_like_C_C PF10104.9 ORX46744.1 - 2.2e-30 105.1 0.9 3e-30 104.7 0.9 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Carn_acyltransf PF00755.20 ORX46745.1 - 4.1e-178 593.7 0.3 4.6e-178 593.5 0.3 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Arrestin_C PF02752.22 ORX46746.1 - 8.9e-15 55.3 3.9 1.1e-10 42.1 0.5 2.6 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX46746.1 - 6.1e-09 36.1 0.0 4.3e-06 26.8 0.1 3.4 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX46746.1 - 0.0002 21.1 0.1 0.028 14.1 0.0 2.3 2 0 0 2 2 2 2 Arrestin_N terminal like VPS9 PF02204.18 ORX46747.1 - 2.5e-14 53.4 0.1 2.5e-13 50.2 0.1 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain SUIM_assoc PF16619.5 ORX46747.1 - 0.049 13.7 3.5 0.067 13.3 0.2 2.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AKAP7_NLS PF10469.9 ORX46749.1 - 1e-06 28.8 0.0 1.3e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain AMP-binding PF00501.28 ORX46750.1 - 7.1e-71 239.0 0.0 1.2e-70 238.3 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme NAD_binding_4 PF07993.12 ORX46750.1 - 3.1e-67 226.4 0.0 4.5e-67 225.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein Condensation PF00668.20 ORX46750.1 - 9.6e-16 57.5 0.4 1.9e-14 53.2 0.4 2.2 1 1 0 1 1 1 1 Condensation domain PP-binding PF00550.25 ORX46750.1 - 1.5e-12 47.7 0.0 3.5e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ORX46750.1 - 3.4e-09 36.5 0.0 6.3e-09 35.6 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family AMP-binding_C PF13193.6 ORX46750.1 - 8.1e-06 26.7 0.0 2.9e-05 24.9 0.0 2.1 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 ORX46750.1 - 6e-05 22.2 0.0 0.00014 21.0 0.0 1.6 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ORX46750.1 - 0.01 15.7 0.0 3.8 7.4 0.0 2.6 2 0 0 2 2 2 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ORX46750.1 - 0.12 11.7 0.0 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase SNF2_N PF00176.23 ORX46751.1 - 6.5e-55 186.3 1.2 1.4e-44 152.2 0.4 2.8 2 1 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX46751.1 - 5.1e-16 59.0 0.0 3.1e-15 56.5 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX46751.1 - 5.8e-11 42.7 0.1 1.1e-10 41.7 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX46751.1 - 6.5e-07 29.3 0.0 5.9e-06 26.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-C3HC4 PF00097.25 ORX46751.1 - 1.5e-05 24.8 4.3 1.5e-05 24.8 4.3 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX46751.1 - 7.8e-05 22.4 3.5 7.8e-05 22.4 3.5 2.6 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX46751.1 - 0.00052 20.0 0.8 0.0016 18.4 0.3 2.2 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX46751.1 - 0.0034 17.7 4.4 0.0034 17.7 4.4 2.6 2 0 0 2 2 1 1 Ring finger domain zf-RING_5 PF14634.6 ORX46751.1 - 0.01 15.8 4.2 0.01 15.8 4.2 2.5 2 0 0 2 2 1 0 zinc-RING finger domain AAA_22 PF13401.6 ORX46751.1 - 0.1 12.8 0.0 0.37 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain YL1 PF05764.13 ORX46751.1 - 0.24 11.5 9.3 0.42 10.7 9.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ORX46751.1 - 0.44 8.8 10.1 0.69 8.1 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein PRCC PF10253.9 ORX46751.1 - 0.44 11.3 7.5 0.73 10.6 7.5 1.3 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Zn_Tnp_IS91 PF14319.6 ORX46751.1 - 0.81 9.8 13.6 0.34 11.0 2.3 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain DEAD_2 PF06733.15 ORX46751.1 - 1.8 8.1 4.9 0.55 9.8 0.3 2.5 2 1 0 2 2 2 0 DEAD_2 FlhC PF05280.11 ORX46751.1 - 5.5 6.7 9.0 10 5.8 0.2 2.8 2 1 1 3 3 3 0 Flagellar transcriptional activator (FlhC) DNA_pol_phi PF04931.13 ORX46751.1 - 8.1 4.4 14.1 13 3.7 14.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi XendoU PF09412.10 ORX46752.1 - 0.054 12.7 0.4 0.081 12.1 0.4 1.3 1 0 0 1 1 1 0 Endoribonuclease XendoU DUF3533 PF12051.8 ORX46752.1 - 1.8 7.4 4.3 0.51 9.2 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3533) AIM5 PF17050.5 ORX46753.1 - 0.00028 21.7 0.2 0.17 12.7 0.0 2.2 1 1 1 2 2 2 2 Altered inheritance of mitochondria 5 DUF3328 PF11807.8 ORX46753.1 - 0.031 14.1 0.1 0.034 13.9 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) zf-C4H2 PF10146.9 ORX46754.1 - 0.00093 19.6 11.2 0.0011 19.3 11.2 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein Atg14 PF10186.9 ORX46754.1 - 0.0091 15.1 14.8 0.011 14.8 14.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 HHA PF05321.11 ORX46754.1 - 0.041 14.2 2.3 2.1 8.8 0.3 2.4 2 0 0 2 2 2 0 Haemolysin expression modulating protein TMCO5 PF14992.6 ORX46754.1 - 0.27 10.8 15.5 0.32 10.5 15.5 1.1 1 0 0 1 1 1 0 TMCO5 family RSS_P20 PF11757.8 ORX46754.1 - 0.32 11.5 6.6 0.34 11.4 5.5 1.6 1 1 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain V_ATPase_I PF01496.19 ORX46754.1 - 0.38 8.6 7.9 0.42 8.5 7.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKA1 PF07160.12 ORX46754.1 - 0.51 10.1 16.5 1.1 9.1 16.3 1.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 CENP-O PF09496.10 ORX46754.1 - 0.82 9.6 7.8 1.1 9.3 7.8 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component Exonuc_VII_L PF02601.15 ORX46754.1 - 1.2 8.7 10.3 1.4 8.5 10.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2935 PF11155.8 ORX46754.1 - 1.6 9.1 10.1 2.4 8.5 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) NAM-associated PF14303.6 ORX46754.1 - 3.7 8.2 12.3 5 7.8 12.3 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3450 PF11932.8 ORX46754.1 - 4.5 6.5 14.1 6.1 6.1 14.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Perilipin PF03036.16 ORX46754.1 - 6 5.8 12.9 7.4 5.5 12.9 1.1 1 0 0 1 1 1 0 Perilipin family DP PF08781.10 ORX46754.1 - 8.5 6.3 15.2 0.3 11.0 7.0 2.0 1 1 1 2 2 2 0 Transcription factor DP DUF883 PF05957.13 ORX46754.1 - 9.5 6.9 8.2 11 6.6 7.1 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) Lysine_decarbox PF03641.14 ORX46755.1 - 5.3e-37 126.9 0.0 6.9e-37 126.5 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 ORX46755.1 - 0.00022 20.9 0.0 0.00032 20.3 0.0 1.3 1 1 0 1 1 1 1 SLOG cluster4 family SNARE PF05739.19 ORX46756.1 - 6.4e-13 48.5 3.7 1.3e-12 47.5 0.1 2.8 2 0 0 2 2 2 1 SNARE domain Syntaxin-5_N PF11416.8 ORX46756.1 - 1e-07 31.0 0.7 2.5e-07 29.7 0.2 2.0 2 0 0 2 2 2 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin-18_N PF10496.9 ORX46756.1 - 0.00017 21.8 0.9 0.00017 21.8 0.9 3.2 2 1 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus Syntaxin PF00804.25 ORX46756.1 - 0.00037 20.2 6.4 0.00037 20.2 6.4 3.5 3 1 1 4 4 4 2 Syntaxin DUF948 PF06103.11 ORX46756.1 - 0.26 11.6 14.8 4.1 7.7 3.5 3.9 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Peripla_BP_2 PF01497.18 ORX46756.1 - 0.31 10.5 9.7 0.021 14.4 3.0 2.3 3 0 0 3 3 3 0 Periplasmic binding protein FlaC_arch PF05377.11 ORX46756.1 - 0.94 9.9 8.6 0.56 10.6 0.7 3.7 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) AI-2E_transport PF01594.16 ORX46756.1 - 3.1 6.9 7.8 0.33 10.1 2.8 1.9 2 0 0 2 2 2 0 AI-2E family transporter NPV_P10 PF05531.12 ORX46756.1 - 6.8 7.2 17.5 0.79 10.2 1.8 4.1 3 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein OrfB_Zn_ribbon PF07282.11 ORX46757.1 - 0.013 15.4 4.1 0.2 11.6 4.1 2.2 1 1 0 1 1 1 0 Putative transposase DNA-binding domain SPATA3 PF15662.5 ORX46757.1 - 0.04 14.6 5.5 0.051 14.2 5.5 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family MCPVI PF02993.14 ORX46757.1 - 0.072 12.9 0.8 0.091 12.6 0.8 1.1 1 0 0 1 1 1 0 Minor capsid protein VI Alg14 PF08660.11 ORX46761.1 - 2.9e-58 196.7 0.0 4.1e-58 196.2 0.0 1.2 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like Glyco_transf_28 PF03033.20 ORX46761.1 - 0.078 13.0 0.0 0.11 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain HAD_2 PF13419.6 ORX46762.1 - 2.6e-07 30.9 0.0 5.9e-07 29.7 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX46762.1 - 7.1e-07 29.7 0.1 2.2e-06 28.1 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX46762.1 - 0.00015 21.8 0.0 0.00029 20.8 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Cul7 PF11515.8 ORX46762.1 - 0.09 13.1 0.0 0.47 10.8 0.0 2.1 3 0 0 3 3 3 0 Mouse development and cellular proliferation protein Cullin-7 Zn_ribbon_SprT PF17283.2 ORX46763.1 - 0.0057 16.5 5.2 0.12 12.3 2.3 2.3 2 0 0 2 2 2 2 SprT-like zinc ribbon domain GFA PF04828.14 ORX46763.1 - 0.078 13.3 0.0 0.16 12.3 0.0 1.5 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Pkinase PF00069.25 ORX46764.1 - 1.3e-42 146.0 0.7 5.8e-21 75.0 0.0 2.7 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX46764.1 - 7.9e-15 54.8 0.0 1.7e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX46764.1 - 0.054 12.3 0.1 0.28 9.9 0.0 1.9 1 1 1 2 2 2 0 Fungal protein kinase Wbp11 PF09429.10 ORX46764.1 - 0.12 12.8 7.0 0.29 11.5 7.0 1.6 1 0 0 1 1 1 0 WW domain binding protein 11 DUF3818 PF12825.7 ORX46765.1 - 1.1e-65 221.9 0.1 2.7e-62 210.7 0.1 2.3 1 1 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PX PF00787.24 ORX46765.1 - 4e-09 36.4 0.2 1.3e-08 34.8 0.2 1.9 1 0 0 1 1 1 1 PX domain PXB PF12828.7 ORX46765.1 - 8.8e-05 22.5 1.6 0.00049 20.1 1.6 2.3 1 1 0 1 1 1 1 PX-associated HTH_23 PF13384.6 ORX46766.1 - 9.1e-05 22.1 0.0 0.00043 20.0 0.0 2.2 2 0 0 2 2 2 1 Homeodomain-like domain Myb_DNA-bind_6 PF13921.6 ORX46766.1 - 0.0018 18.5 1.0 0.0046 17.2 1.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX46766.1 - 0.0025 18.0 0.3 0.0058 16.8 0.3 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF3489 PF11994.8 ORX46766.1 - 0.02 14.9 0.0 0.04 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3489) HTH_29 PF13551.6 ORX46766.1 - 0.047 13.7 0.0 0.093 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix DUF2369 PF10179.9 ORX46766.1 - 0.085 13.3 0.4 1.2 9.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) HAD_2 PF13419.6 ORX46767.1 - 1.4e-23 83.8 0.0 1.7e-23 83.6 0.0 1.0 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX46767.1 - 1.6e-12 48.1 0.0 1.6e-11 44.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX46767.1 - 0.00023 21.2 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ORX46767.1 - 0.0088 16.5 0.0 0.012 16.1 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LEM PF03020.15 ORX46767.1 - 0.086 12.4 0.1 0.23 11.1 0.1 1.7 1 0 0 1 1 1 0 LEM domain Aminotran_1_2 PF00155.21 ORX46768.1 - 9.9e-50 169.7 0.0 1.4e-49 169.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX46768.1 - 0.00041 19.7 0.0 0.0007 19.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ORX46768.1 - 0.0023 16.6 0.0 0.0045 15.6 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ORX46768.1 - 0.0047 15.9 0.0 0.007 15.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 ORX46768.1 - 0.017 13.8 0.0 0.035 12.9 0.0 1.4 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain DegT_DnrJ_EryC1 PF01041.17 ORX46768.1 - 0.12 11.7 0.0 0.45 9.8 0.0 1.8 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cullin_Nedd8 PF10557.9 ORX46768.1 - 0.16 12.0 0.0 0.37 10.9 0.0 1.6 1 0 0 1 1 1 0 Cullin protein neddylation domain TPR_11 PF13414.6 ORX46770.1 - 8e-06 25.4 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 ORX46770.1 - 2.7e-05 23.8 0.1 5.1e-05 22.9 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX46770.1 - 0.00011 22.0 0.1 0.00027 20.8 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX46770.1 - 0.0066 16.6 0.1 0.017 15.3 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX46770.1 - 0.018 15.9 0.0 0.068 14.0 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX46770.1 - 0.035 14.8 0.0 0.086 13.5 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX46770.1 - 0.085 13.3 0.1 0.57 10.7 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX46770.1 - 0.17 12.4 0.0 0.35 11.4 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Complex1_LYR PF05347.15 ORX46771.1 - 7.6e-08 32.3 0.1 1.1e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DNA_pol3_delta2 PF13177.6 ORX46773.1 - 7.7e-15 55.1 0.2 1.7e-14 53.9 0.2 1.6 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 ORX46773.1 - 3e-09 37.4 0.0 6.3e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX46773.1 - 5.8e-05 23.4 0.0 0.00016 21.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ORX46773.1 - 0.00023 21.2 0.0 0.00067 19.6 0.0 1.8 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 ORX46773.1 - 0.0013 18.5 0.0 0.5 10.1 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 ORX46773.1 - 0.0056 16.5 0.3 0.012 15.4 0.3 1.6 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 ORX46773.1 - 0.0059 17.0 0.5 0.089 13.2 0.1 2.7 1 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 ORX46773.1 - 0.028 13.6 0.0 0.078 12.1 0.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 ORX46773.1 - 0.03 14.0 0.4 0.083 12.6 0.4 1.7 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ORX46773.1 - 0.045 13.8 0.2 0.27 11.2 0.2 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ORX46773.1 - 0.083 13.4 0.0 0.21 12.1 0.0 1.6 1 1 0 1 1 1 0 ABC transporter F-box-like PF12937.7 ORX46774.1 - 2.8e-06 27.1 0.4 5.4e-06 26.2 0.4 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX46774.1 - 0.007 16.2 0.1 0.017 15.0 0.1 1.7 1 1 0 1 1 1 1 F-box domain TraO PF10626.9 ORX46774.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Conjugative transposon protein TraO Rax2 PF12768.7 ORX46775.1 - 1.6e-29 102.9 3.0 3.4e-27 95.3 0.3 4.2 3 1 1 4 4 4 2 Cortical protein marker for cell polarity Reg_prop PF07494.11 ORX46775.1 - 0.0018 18.3 3.3 27 5.5 0.1 5.5 4 0 0 4 4 4 1 Two component regulator propeller Big_2 PF02368.18 ORX46775.1 - 0.17 11.8 4.4 0.75 9.7 4.4 2.2 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 2) RhoGAP PF00620.27 ORX46776.1 - 1.8e-45 154.4 0.0 5.4e-45 152.9 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 ORX46776.1 - 7.6e-11 42.5 0.0 1.7e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 PH domain WW PF00397.26 ORX46776.1 - 8.7e-10 38.5 1.3 1.8e-09 37.5 1.3 1.6 1 0 0 1 1 1 1 WW domain PH_9 PF15410.6 ORX46776.1 - 0.0008 19.8 0.0 0.0019 18.5 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Fumble PF03630.14 ORX46777.1 - 1e-133 445.6 0.2 1.7e-133 444.9 0.2 1.3 1 1 0 1 1 1 1 Fumble SH3_1 PF00018.28 ORX46778.1 - 1.9e-07 30.6 0.0 3.6e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX46778.1 - 4.1e-05 23.4 0.0 8.8e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX46778.1 - 0.023 15.0 0.2 0.047 14.0 0.2 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain GRASP55_65 PF04495.14 ORX46780.1 - 1.5e-65 219.6 0.0 6.3e-53 178.8 0.0 2.1 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_2 PF13180.6 ORX46780.1 - 2.3e-07 31.0 0.0 4.7e-05 23.6 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ_6 PF17820.1 ORX46780.1 - 2.9e-07 30.2 0.0 0.00028 20.7 0.0 2.5 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 ORX46780.1 - 0.02 14.9 0.0 0.065 13.2 0.0 1.8 2 0 0 2 2 2 0 Tricorn protease PDZ domain Transthyretin PF00576.21 ORX46781.1 - 3.5e-38 130.7 0.1 4e-38 130.5 0.1 1.0 1 0 0 1 1 1 1 HIUase/Transthyretin family CarboxypepD_reg PF13620.6 ORX46781.1 - 0.088 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Carboxypeptidase regulatory-like domain MRP-S25 PF13741.6 ORX46782.1 - 6.3e-43 147.0 2.0 1e-42 146.3 2.0 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 ORX46782.1 - 1.1e-05 25.7 2.9 0.044 14.0 0.6 2.7 2 1 0 2 2 2 2 Mitochondrial ribosomal protein S23 DUF3480 PF11979.8 ORX46782.1 - 0.13 11.2 0.3 0.17 10.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) Sel1 PF08238.12 ORX46783.1 - 1.6e-31 108.0 22.2 1.9e-07 31.5 0.1 6.8 7 0 0 7 7 7 6 Sel1 repeat TAP_C PF03943.13 ORX46783.1 - 0.45 10.2 2.3 1.2 8.8 0.0 2.9 3 1 0 3 3 3 0 TAP C-terminal domain DUF3808 PF10300.9 ORX46784.1 - 2.1e-62 211.4 8.4 2.8e-62 211.0 8.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_6 PF13174.6 ORX46784.1 - 0.0021 18.6 4.3 5.8 7.8 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX46784.1 - 0.016 15.2 8.2 19 5.7 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat RRM_1 PF00076.22 ORX46785.1 - 3.1e-20 71.8 0.2 4.7e-20 71.2 0.2 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) U1snRNP70_N PF12220.8 ORX46785.1 - 2.6e-17 63.2 2.1 2.6e-17 63.2 2.1 2.1 3 0 0 3 3 3 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_5 PF13893.6 ORX46785.1 - 0.05 13.2 0.0 0.073 12.7 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX46785.1 - 0.078 13.1 0.5 0.49 10.5 0.1 2.3 2 1 0 2 2 2 0 RNA recognition motif PAP_central PF04928.17 ORX46786.1 - 1.2e-94 315.9 0.0 1.6e-94 315.5 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ORX46786.1 - 5.4e-20 71.7 0.0 2.1e-19 69.8 0.0 2.1 1 1 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ORX46786.1 - 6.3e-06 26.4 0.0 1.3e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ORX46786.1 - 0.081 12.7 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 ORX46786.1 - 0.15 12.1 0.0 0.52 10.4 0.0 1.9 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase LSM PF01423.22 ORX46788.1 - 6e-12 45.1 0.0 6.8e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX46788.1 - 0.0044 17.1 0.0 0.008 16.3 0.0 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain Tudor_2 PF18104.1 ORX46788.1 - 0.04 13.6 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain Septin PF00735.18 ORX46789.1 - 2.5e-112 374.8 0.9 3.1e-112 374.5 0.9 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX46789.1 - 2.3e-09 37.3 0.1 2.6e-08 33.9 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX46789.1 - 5e-07 29.8 0.3 4.1e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ORX46789.1 - 6.5e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 ORX46789.1 - 2.6e-05 23.9 0.1 0.001 18.6 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX46789.1 - 0.00024 21.5 0.0 0.0021 18.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Dynamin_N PF00350.23 ORX46789.1 - 0.00028 21.0 0.8 0.75 9.8 0.3 2.6 1 1 1 2 2 2 2 Dynamin family NB-ARC PF00931.22 ORX46789.1 - 0.00083 18.6 0.7 0.0017 17.6 0.1 1.7 2 0 0 2 2 2 1 NB-ARC domain Gtr1_RagA PF04670.12 ORX46789.1 - 0.0012 18.2 0.1 0.018 14.4 0.0 2.1 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_14 PF13173.6 ORX46789.1 - 0.0014 18.7 0.0 0.0062 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ORX46789.1 - 0.003 18.1 0.0 0.0078 16.7 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 ORX46789.1 - 0.0039 17.5 0.0 0.0085 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 ORX46789.1 - 0.006 16.0 0.0 0.01 15.2 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family Roc PF08477.13 ORX46789.1 - 0.011 16.0 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 ORX46789.1 - 0.014 14.9 0.0 0.054 13.0 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_29 PF13555.6 ORX46789.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ras PF00071.22 ORX46789.1 - 0.041 13.5 0.0 0.095 12.3 0.0 1.6 1 0 0 1 1 1 0 Ras family G-alpha PF00503.20 ORX46789.1 - 0.067 12.3 0.5 0.52 9.4 0.1 2.0 1 1 1 2 2 2 0 G-protein alpha subunit Sigma54_activat PF00158.26 ORX46789.1 - 0.077 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ORX46789.1 - 0.078 12.1 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 ORX46789.1 - 0.11 12.7 0.4 0.48 10.6 0.2 2.2 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX46789.1 - 0.19 11.4 0.3 0.47 10.2 0.1 1.9 2 1 0 2 2 2 0 AAA domain Pectate_lyase_3 PF12708.7 ORX46790.1 - 4.2e-12 46.4 1.3 1.9e-11 44.3 0.0 2.4 2 1 1 3 3 3 1 Pectate lyase superfamily protein End_N_terminal PF12218.8 ORX46790.1 - 0.05 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 N terminal extension of bacteriophage endosialidase Ifi-6-16 PF06140.13 ORX46791.1 - 4e-13 49.1 20.8 5.8e-13 48.6 20.8 1.3 1 1 0 1 1 1 1 Interferon-induced 6-16 family DUF4781 PF16013.5 ORX46791.1 - 0.0021 16.9 2.9 0.0021 16.9 2.9 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4781) Amino_oxidase PF01593.24 ORX46793.1 - 8.1e-63 213.3 0.1 2.4e-61 208.4 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX46793.1 - 1.7e-08 34.5 0.0 6.4e-08 32.7 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX46793.1 - 2.2e-06 27.5 0.1 0.00011 21.9 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX46793.1 - 2.6e-06 26.9 1.6 0.039 13.2 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX46793.1 - 9.6e-05 21.8 2.6 0.053 12.8 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX46793.1 - 0.0007 20.1 2.3 0.078 13.5 0.2 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX46793.1 - 0.0014 18.0 0.2 0.0025 17.1 0.2 1.4 1 0 0 1 1 1 1 FAD binding domain NAR2 PF16974.5 ORX46793.1 - 0.019 14.4 0.2 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 High-affinity nitrate transporter accessory FAD_oxidored PF12831.7 ORX46793.1 - 0.04 13.3 0.5 0.094 12.0 0.2 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ORX46793.1 - 0.17 11.1 0.3 0.29 10.4 0.3 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ORX46793.1 - 0.17 10.9 0.4 0.26 10.3 0.4 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 ORX46793.1 - 0.31 9.7 3.8 7.9 5.1 0.2 3.0 3 0 0 3 3 3 0 HI0933-like protein Methyltransf_25 PF13649.6 ORX46794.1 - 1.7e-11 44.7 0.0 1.6e-10 41.6 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX46794.1 - 4e-09 36.5 0.0 5.5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX46794.1 - 5.6e-09 36.5 0.0 9.9e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX46794.1 - 3.5e-08 33.4 0.0 1.8e-07 31.1 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX46794.1 - 0.00026 20.4 0.0 0.00054 19.4 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX46794.1 - 0.029 15.1 0.0 0.11 13.2 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain DUF1935 PF09149.10 ORX46794.1 - 0.21 12.0 0.4 0.59 10.5 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1935) WD40 PF00400.32 ORX46795.1 - 1.2e-42 143.1 21.9 2.9e-08 34.2 0.3 12.2 13 0 0 13 13 13 8 WD domain, G-beta repeat Utp12 PF04003.12 ORX46795.1 - 3.5e-26 91.6 0.0 5.7e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 ORX46795.1 - 5e-23 81.2 0.0 0.011 16.1 0.0 9.8 5 2 5 11 11 11 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX46795.1 - 2.4e-09 37.4 1.1 0.02 14.8 0.1 5.2 3 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ORX46795.1 - 5.7e-08 32.2 0.0 0.003 16.7 0.0 3.3 3 0 0 3 3 3 2 Coatomer WD associated region Ge1_WD40 PF16529.5 ORX46795.1 - 2.5e-06 26.7 4.2 3.7 6.4 0.0 6.6 4 3 3 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX46795.1 - 0.00065 19.1 0.1 1.6 7.9 0.0 3.5 5 0 0 5 5 5 2 WD40-like domain RAB3GAP2_N PF14655.6 ORX46795.1 - 0.0017 17.7 0.2 1.5 8.0 0.0 3.3 2 1 1 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus Nbas_N PF15492.6 ORX46795.1 - 0.044 13.1 0.3 20 4.4 0.0 4.4 3 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Utp13 PF08625.11 ORX46795.1 - 0.083 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Utp13 specific WD40 associated domain DciA PF05258.12 ORX46795.1 - 0.19 12.2 0.0 0.36 11.3 0.0 1.4 1 0 0 1 1 1 0 Dna[CI] antecedent, DciA PQQ_3 PF13570.6 ORX46795.1 - 5.4 7.7 12.5 3.5 8.2 0.0 5.6 6 0 0 6 6 6 0 PQQ-like domain FmiP_Thoc5 PF09766.9 ORX46796.1 - 8.2e-25 87.9 6.7 9.4e-25 87.7 6.7 1.0 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Pyr_redox_2 PF07992.14 ORX46798.1 - 2.2e-71 240.5 7.4 2.2e-71 240.5 7.4 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX46798.1 - 7.3e-42 142.1 0.7 2.4e-41 140.4 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ORX46798.1 - 6.7e-20 71.4 7.3 7.3e-18 64.9 1.3 3.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX46798.1 - 1.1e-12 48.0 5.2 3.5e-10 39.8 0.3 2.5 2 1 1 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ORX46798.1 - 2.5e-12 46.7 5.9 4.7e-10 39.2 0.3 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX46798.1 - 7.5e-11 41.7 4.1 2.1e-09 36.9 0.6 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ORX46798.1 - 8.5e-09 35.0 13.2 1.8e-06 27.4 0.7 4.1 2 1 2 4 4 4 2 FAD binding domain NAD_binding_8 PF13450.6 ORX46798.1 - 3.2e-08 33.7 2.0 0.00012 22.2 0.1 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ORX46798.1 - 4.7e-07 29.3 0.6 0.0016 17.6 0.1 2.8 2 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ORX46798.1 - 1e-06 27.8 11.2 0.00017 20.4 0.3 4.1 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 ORX46798.1 - 4.2e-06 26.2 6.7 2.3e-05 23.8 0.4 2.5 1 1 1 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ORX46798.1 - 1.1e-05 24.9 9.3 0.013 14.8 0.3 3.6 3 1 0 3 3 3 2 FAD binding domain AlaDh_PNT_C PF01262.21 ORX46798.1 - 4e-05 23.0 2.6 0.0045 16.3 1.2 3.1 2 1 1 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 ORX46798.1 - 0.0065 16.1 16.6 0.037 13.6 0.2 4.0 3 1 1 4 4 4 1 FAD dependent oxidoreductase 3HCDH_N PF02737.18 ORX46798.1 - 0.01 15.8 3.9 0.096 12.6 0.5 2.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ORX46798.1 - 0.021 14.4 4.7 0.39 10.3 0.9 2.7 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Lycopene_cycl PF05834.12 ORX46798.1 - 0.032 13.3 0.1 0.032 13.3 0.1 2.7 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 ORX46798.1 - 0.04 14.3 1.6 7.8 7.0 0.2 3.2 3 0 0 3 3 3 0 Putative NAD(P)-binding Amino_oxidase PF01593.24 ORX46798.1 - 0.15 11.3 0.1 0.31 10.3 0.1 1.5 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase DUF737 PF05300.11 ORX46799.1 - 4.8 7.5 19.5 0.076 13.4 8.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF737) DUF726 PF05277.12 ORX46800.1 - 1.9e-89 300.0 0.0 2.6e-89 299.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Thioesterase PF00975.20 ORX46800.1 - 0.081 13.0 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain DUF4225 PF13988.6 ORX46800.1 - 0.085 12.4 0.1 0.14 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) DUF2207 PF09972.9 ORX46800.1 - 0.11 11.3 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Phage_holin_3_6 PF07332.11 ORX46800.1 - 2.3 8.3 9.0 0.33 11.0 2.8 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III CLP1_P PF16575.5 ORX46801.1 - 7.6e-37 126.9 0.0 1.8e-36 125.7 0.0 1.6 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase_2 PF01637.18 ORX46801.1 - 0.005 16.8 0.0 0.012 15.6 0.0 1.5 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ORX46801.1 - 0.036 14.2 0.0 0.066 13.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase MobB PF03205.14 ORX46801.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ORX46801.1 - 0.093 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX46801.1 - 0.093 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase zf-C2H2 PF00096.26 ORX46802.1 - 5.7e-22 76.9 24.7 3.2e-06 27.3 0.2 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX46802.1 - 5.6e-21 74.0 23.5 2.7e-07 30.7 0.0 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX46802.1 - 1.2e-12 47.5 23.1 0.0082 16.9 0.2 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger FOXP-CC PF16159.5 ORX46802.1 - 1.1e-05 25.9 7.0 0.095 13.3 0.5 3.6 3 1 0 3 3 3 2 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX46802.1 - 5.4e-05 23.4 4.2 4.6 7.7 0.1 4.6 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ORX46802.1 - 7.8e-05 22.9 10.0 0.0039 17.4 0.6 2.3 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-TRAF PF02176.18 ORX46802.1 - 0.015 16.0 1.6 0.015 16.0 1.6 3.2 1 1 3 4 4 4 0 TRAF-type zinc finger zf-C2H2_11 PF16622.5 ORX46802.1 - 0.074 12.8 0.6 0.074 12.8 0.6 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type DUF448 PF04296.13 ORX46802.1 - 0.076 12.9 0.2 8.5 6.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF448) Ogr_Delta PF04606.12 ORX46802.1 - 0.38 10.8 0.1 0.38 10.8 0.1 3.6 2 1 3 5 5 5 0 Ogr/Delta-like zinc finger zf-C2HC_2 PF13913.6 ORX46802.1 - 0.39 10.7 12.8 0.65 10.0 0.5 3.7 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 ORX46802.1 - 1.1 9.0 22.9 0.35 10.7 0.3 5.1 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-met PF12874.7 ORX46802.1 - 1.3 9.5 6.8 33 5.0 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type PBP1_TM PF14812.6 ORX46802.1 - 2 8.9 6.2 3.8 8.0 6.2 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2_aberr PF17017.5 ORX46802.1 - 2.2 8.4 8.7 11 6.2 0.7 3.5 1 1 2 4 4 4 0 Aberrant zinc-finger Aha1_N PF09229.11 ORX46803.1 - 6.5e-40 136.5 2.0 1.3e-39 135.6 2.0 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 ORX46803.1 - 1e-20 74.2 0.3 2e-20 73.3 0.3 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Afi1 PF07792.12 ORX46803.1 - 0.022 15.2 0.3 0.035 14.6 0.3 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Polyketide_cyc2 PF10604.9 ORX46803.1 - 0.043 14.1 0.4 0.097 12.9 0.4 1.6 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport BsuPI PF12690.7 ORX46803.1 - 0.05 13.6 0.4 5.8 7.0 0.1 3.0 3 0 0 3 3 3 0 Intracellular proteinase inhibitor RPE65 PF03055.15 ORX46804.1 - 5.9e-91 306.0 0.2 7.1e-91 305.7 0.2 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein SLD5_C PF16922.5 ORX46805.1 - 6.2e-14 51.9 0.1 1.2e-13 51.0 0.1 1.5 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 ORX46805.1 - 0.0002 21.8 5.2 0.00049 20.5 3.9 2.3 1 1 0 1 1 1 1 GINS complex protein BLM10_mid PF16507.5 ORX46805.1 - 0.021 13.5 0.2 0.026 13.2 0.2 1.1 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region RCC1 PF00415.18 ORX46806.1 - 4.3e-09 36.9 0.5 2.8e-05 24.7 0.0 2.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX46806.1 - 2.6e-07 30.3 0.0 3.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat FH2 PF02181.23 ORX46807.1 - 5.1e-73 246.3 14.5 5.1e-73 246.3 14.5 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ORX46807.1 - 1.9e-32 112.3 5.7 8.4e-31 107.0 2.1 4.0 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX46807.1 - 3.1e-20 72.6 0.1 3.1e-20 72.6 0.1 3.7 4 0 0 4 4 4 1 Diaphanous FH3 Domain WXG100 PF06013.12 ORX46807.1 - 0.015 15.6 1.3 0.015 15.6 1.3 3.5 3 0 0 3 3 3 0 Proteins of 100 residues with WXG GCR1_C PF12550.8 ORX46807.1 - 0.14 12.5 0.3 1.9 8.8 0.0 2.8 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes DivIC PF04977.15 ORX46807.1 - 2.1 8.1 10.4 0.49 10.2 0.7 3.5 3 0 0 3 3 3 0 Septum formation initiator Seryl_tRNA_N PF02403.22 ORX46807.1 - 3.2 8.0 17.5 1.3 9.3 2.4 3.9 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Hemerythrin PF01814.23 ORX46807.1 - 6 7.5 7.1 29 5.3 6.8 2.4 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain zf-C3HC4_3 PF13920.6 ORX46810.1 - 0.0015 18.4 7.9 0.0024 17.7 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 ORX46810.1 - 1.8 8.8 7.9 1.4 9.2 6.0 1.8 1 1 0 1 1 1 0 B-box zinc finger Lectin_leg-like PF03388.13 ORX46811.1 - 4.4e-60 202.9 0.0 6e-60 202.4 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family GTSE1_N PF15259.6 ORX46811.1 - 0.021 15.0 0.1 0.06 13.5 0.1 1.7 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 Bact_lectin PF18483.1 ORX46811.1 - 0.027 14.5 0.0 0.06 13.4 0.0 1.7 1 0 0 1 1 1 0 Bacterial lectin Baculo_PEP_C PF04513.12 ORX46811.1 - 0.12 12.4 0.8 0.22 11.6 0.8 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Jnk-SapK_ap_N PF09744.9 ORX46811.1 - 0.79 9.9 5.7 5.7 7.1 0.6 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 CdvA PF18822.1 ORX46811.1 - 3.6 7.4 7.1 2.5 7.9 2.7 2.3 2 1 0 2 2 2 0 CdvA-like coiled-coil domain zinc_ribbon_6 PF14599.6 ORX46812.1 - 2.7e-22 78.5 1.6 2.7e-22 78.5 1.6 4.7 3 1 1 4 4 4 1 Zinc-ribbon zf-CHY PF05495.12 ORX46812.1 - 1.1e-20 73.9 17.1 1.1e-20 73.9 17.1 4.4 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 ORX46812.1 - 1.2e-07 32.0 9.8 1.2e-07 32.0 9.8 5.8 2 2 2 4 4 4 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX46812.1 - 1.9e-05 24.6 2.4 1.9e-05 24.6 2.4 5.7 4 2 1 5 5 5 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX46812.1 - 0.00048 19.9 8.8 0.00048 19.9 8.8 6.4 5 2 2 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX46812.1 - 0.00052 19.9 11.2 0.00052 19.9 11.2 7.3 5 2 2 7 7 7 1 zinc-RING finger domain Prok-RING_1 PF14446.6 ORX46812.1 - 0.0086 16.0 2.8 0.0086 16.0 2.8 6.4 4 2 1 6 6 6 1 Prokaryotic RING finger family 1 zf-B_box PF00643.24 ORX46812.1 - 0.076 13.2 1.3 0.076 13.2 1.3 8.4 9 0 0 9 9 9 0 B-box zinc finger UPF0172 PF03665.13 ORX46813.1 - 6.6e-46 156.8 0.3 8.4e-46 156.4 0.3 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) JAB PF01398.21 ORX46813.1 - 0.014 15.4 0.0 0.19 11.7 0.0 2.1 1 1 1 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease WD40 PF00400.32 ORX46814.1 - 1.4e-09 38.4 17.4 0.16 12.9 0.1 7.2 6 1 0 6 6 6 4 WD domain, G-beta repeat PQQ_2 PF13360.6 ORX46814.1 - 0.072 12.7 0.0 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 PQQ-like domain ANAPC4_WD40 PF12894.7 ORX46814.1 - 0.13 12.6 0.2 1.5 9.1 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SR-25 PF10500.9 ORX46815.1 - 0.085 12.5 8.8 0.13 11.9 8.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC24 PF15669.5 ORX46815.1 - 0.11 12.4 1.0 0.23 11.3 1.0 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family CytochromB561_N PF09786.9 ORX46816.1 - 0.014 14.5 0.2 0.017 14.2 0.2 1.1 1 0 0 1 1 1 0 Cytochrome B561, N terminal PPR_2 PF13041.6 ORX46817.1 - 1.6e-20 73.0 0.2 1.1e-07 31.9 0.0 4.1 4 0 0 4 4 4 3 PPR repeat family PPR_1 PF12854.7 ORX46817.1 - 4.8e-09 35.8 0.0 4e-05 23.2 0.0 3.6 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 ORX46817.1 - 6e-09 35.9 0.0 2.2e-05 24.5 0.0 3.4 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 ORX46817.1 - 8.8e-07 28.8 0.3 0.046 14.0 0.0 4.2 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 ORX46817.1 - 2.8e-06 26.9 0.1 0.17 11.2 0.0 3.0 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP DUF4214 PF13946.6 ORX46818.1 - 0.034 14.2 0.0 0.074 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) ABC_tran_CTD PF16326.5 ORX46818.1 - 0.051 13.8 3.2 0.19 12.0 3.1 2.0 1 1 1 2 2 2 0 ABC transporter C-terminal domain SLATT_fungal PF18142.1 ORX46818.1 - 0.16 12.0 0.1 0.23 11.5 0.1 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Ca_bind_SSO6904 PF18249.1 ORX46819.1 - 0.08 13.3 0.1 0.1 12.9 0.1 1.2 1 0 0 1 1 1 0 Calcium binding protein SSO6904 Acetyltransf_1 PF00583.25 ORX46821.1 - 3e-18 66.2 0.0 3.6e-18 65.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX46821.1 - 2.4e-12 46.9 0.1 6e-12 45.6 0.1 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX46821.1 - 3.2e-12 46.7 0.0 4.8e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX46821.1 - 5.4e-06 26.3 0.1 8.6e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ORX46821.1 - 0.0003 20.5 0.0 0.00035 20.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ORX46821.1 - 0.0044 17.7 0.0 0.005 17.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX46821.1 - 0.0047 17.1 0.1 0.0065 16.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX46821.1 - 0.024 14.7 0.0 0.056 13.5 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF2183 PF09949.9 ORX46822.1 - 4.1e-34 116.9 0.0 7.2e-34 116.1 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) zf-C5HC2 PF02928.16 ORX46823.1 - 0.0018 18.6 0.4 0.39 11.1 0.0 2.3 2 0 0 2 2 2 2 C5HC2 zinc finger DUF349 PF03993.12 ORX46954.1 - 0.3 11.4 3.4 0.2 12.0 1.8 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) UBA_e1_thiolCys PF10585.9 ORX46955.1 - 0.019 14.9 0.1 0.021 14.7 0.1 1.0 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site zf-RVT PF13966.6 ORX46956.1 - 2.8e-10 40.8 0.9 4.2e-10 40.2 0.9 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DUF1296 PF06972.11 ORX46959.1 - 0.084 13.0 0.3 0.3 11.2 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) U-box PF04564.15 ORX46959.1 - 0.099 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 U-box domain PhoD_N PF16655.5 ORX46959.1 - 0.17 12.4 2.6 2.6 8.6 0.2 2.5 2 0 0 2 2 2 0 PhoD-like phosphatase, N-terminal domain LRR_6 PF13516.6 ORX46960.1 - 1e-06 28.3 4.6 0.71 10.1 0.0 5.6 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 ORX46960.1 - 3.3e-06 27.3 6.0 0.00071 19.9 0.1 4.6 5 1 0 5 5 5 1 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ORX46960.1 - 8.1e-05 22.4 2.0 0.00021 21.1 2.0 1.8 1 0 0 1 1 1 1 F-box-like LRR_1 PF00560.33 ORX46960.1 - 0.00034 20.8 4.5 12 6.9 0.0 5.6 4 2 0 4 4 4 2 Leucine Rich Repeat LRR_8 PF13855.6 ORX46960.1 - 0.0019 17.9 2.7 0.14 11.9 0.3 3.7 5 0 0 5 5 5 1 Leucine rich repeat Melibiase_2 PF16499.5 ORX46961.1 - 7.5e-11 41.7 0.0 0.00019 20.7 0.0 2.2 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 ORX46961.1 - 2.4e-08 33.9 0.2 1.3e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ORX46961.1 - 0.0022 17.0 0.0 0.0044 16.0 0.0 1.5 1 1 0 1 1 1 1 Melibiase Dus PF01207.17 ORX46962.1 - 7.5e-44 150.1 0.0 8.8e-44 149.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ORX46962.1 - 0.054 12.9 0.0 0.14 11.6 0.0 1.6 2 0 0 2 2 2 0 Histidine biosynthesis protein Ribosomal_L34 PF00468.17 ORX46963.1 - 4.2e-21 74.6 9.0 5.4e-21 74.3 9.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L34 Cation_efflux PF01545.21 ORX46964.1 - 3.5e-54 183.6 9.9 4.3e-54 183.3 9.9 1.1 1 0 0 1 1 1 1 Cation efflux family DUF5134 PF17197.4 ORX46964.1 - 0.00037 20.4 0.0 0.0038 17.1 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF5134) DUF2415 PF10313.9 ORX46966.1 - 1.4e-13 50.6 0.5 1.6e-11 43.9 0.0 3.0 3 0 0 3 3 3 1 Uncharacterised protein domain (DUF2415) WD40 PF00400.32 ORX46966.1 - 1.2e-10 41.8 2.2 0.017 16.0 0.4 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX46966.1 - 5.6e-08 33.0 0.0 0.0026 18.0 0.0 3.8 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain SARS_X4 PF08779.10 ORX46966.1 - 0.00018 21.6 0.0 0.084 13.1 0.0 2.5 2 1 0 2 2 2 2 SARS coronavirus X4 like Lgl_C PF08596.10 ORX46966.1 - 0.006 15.3 0.2 0.035 12.8 0.1 2.0 1 1 1 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal BBS2_Mid PF14783.6 ORX46966.1 - 0.032 14.3 0.1 7.7 6.6 0.0 2.5 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region gpW PF02831.15 ORX46966.1 - 0.16 11.9 0.0 1 9.3 0.0 2.1 2 0 0 2 2 2 0 gpW HgmA PF04209.13 ORX46967.1 - 4.1e-209 694.6 0.0 4.6e-209 694.4 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase zf-CCCH_4 PF18044.1 ORX46968.1 - 1.1e-17 63.4 35.8 7.4e-06 25.6 0.6 4.3 4 0 0 4 4 4 4 CCCH-type zinc finger zf-CCCH PF00642.24 ORX46968.1 - 2.5e-17 62.3 34.0 4.1e-05 23.4 1.6 4.3 3 1 1 4 4 4 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX46968.1 - 7.1e-13 48.2 41.7 3.4e-05 23.8 2.8 4.3 4 0 0 4 4 4 4 Zinc finger domain Torus PF16131.5 ORX46968.1 - 6.7e-08 33.2 24.2 0.015 16.0 0.4 4.1 1 1 3 4 4 4 4 Torus domain zf-CCCH_3 PF15663.5 ORX46968.1 - 4.1e-06 27.0 21.5 0.043 14.0 0.2 4.1 2 1 2 4 4 4 4 Zinc-finger containing family zf-CCCH_2 PF14608.6 ORX46968.1 - 0.00085 19.7 37.2 0.31 11.6 1.0 5.7 4 3 0 4 4 4 3 RNA-binding, Nab2-type zinc finger CRAM_rpt PF07016.11 ORX46968.1 - 0.9 9.4 8.5 31 4.5 0.0 5.0 6 0 0 6 6 6 0 Cysteine-rich acidic integral membrane protein precursor Opy2 PF09463.10 ORX46968.1 - 1.4 9.3 10.0 42 4.6 0.1 4.2 4 0 0 4 4 4 0 Opy2 protein PTPA PF03095.15 ORX46970.1 - 3.9e-121 404.2 0.0 4.4e-121 404.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein Arrestin_N PF00339.29 ORX46971.1 - 0.00021 21.4 0.0 0.00038 20.5 0.0 1.4 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 ORX46971.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 Rgp1 WD40 PF00400.32 ORX46973.1 - 3.4e-57 189.1 14.0 6.3e-08 33.2 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ORX46973.1 - 4.2e-24 84.6 12.2 6.1e-24 84.1 12.2 1.2 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ORX46973.1 - 2e-19 69.6 0.0 0.00087 19.5 0.0 6.2 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX46973.1 - 3.9e-09 36.3 0.0 0.0031 16.9 0.0 5.0 5 1 1 6 6 6 2 WD40-like domain Ge1_WD40 PF16529.5 ORX46973.1 - 3.7e-06 26.1 0.0 0.39 9.6 0.0 4.6 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ORX46973.1 - 2.2e-05 24.2 1.8 0.88 9.6 0.0 5.1 6 0 0 6 6 4 1 WD40-like Beta Propeller Repeat DUF5122 PF17164.4 ORX46973.1 - 5.4e-05 23.4 2.9 29 5.1 0.0 5.6 6 0 0 6 6 5 0 Domain of unknown function (DUF5122) beta-propeller Cytochrom_D1 PF02239.16 ORX46973.1 - 5.6e-05 21.8 0.5 0.051 12.1 0.2 2.9 2 2 1 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ORX46973.1 - 0.0021 17.4 0.0 3.4 6.9 0.0 3.2 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ORX46973.1 - 0.0031 16.2 0.0 0.72 8.4 0.0 3.6 1 1 3 4 4 4 1 Nucleoporin Nup120/160 Spc7 PF08317.11 ORX46973.1 - 0.0042 16.0 3.8 0.0058 15.6 3.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Gmad1 PF10647.9 ORX46973.1 - 0.0055 16.5 0.1 0.2 11.4 0.0 2.2 1 1 1 2 2 2 2 Lipoprotein LpqB beta-propeller domain DUF724 PF05266.14 ORX46973.1 - 0.0065 16.3 1.9 0.01 15.7 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF724) Golgin_A5 PF09787.9 ORX46973.1 - 0.018 14.5 2.4 0.026 14.0 2.4 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Peptidase_S9_N PF02897.15 ORX46973.1 - 0.019 13.8 0.1 0.7 8.6 0.0 2.6 1 1 2 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Jnk-SapK_ap_N PF09744.9 ORX46973.1 - 0.023 14.9 2.4 0.037 14.2 2.4 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 ORX46973.1 - 0.024 14.7 5.2 0.13 12.3 5.1 2.2 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CEP63 PF17045.5 ORX46973.1 - 0.039 13.9 6.7 0.078 12.9 6.7 1.4 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa Ret2_MD PF18528.1 ORX46973.1 - 0.04 14.3 0.0 63 4.0 0.0 4.1 2 1 3 5 5 5 0 RNA editing 3' terminal uridylyl transferase 2 middle domain MMS1_N PF10433.9 ORX46973.1 - 0.043 12.5 0.0 2.3 6.8 0.0 2.2 2 0 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term SHE3 PF17078.5 ORX46973.1 - 0.052 13.2 3.9 0.081 12.6 3.9 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 nos_propeller PF18764.1 ORX46973.1 - 0.061 13.2 0.1 3 7.8 0.0 3.3 3 1 0 4 4 4 0 Nitrous oxide reductase propeller repeat Prp19 PF08606.11 ORX46973.1 - 0.11 12.5 1.4 0.18 11.9 0.2 1.9 2 0 0 2 2 2 0 Prp19/Pso4-like DUF2850 PF11012.8 ORX46973.1 - 0.11 12.8 0.0 0.71 10.2 0.0 2.4 2 0 0 2 2 1 0 Protein of unknown function (DUF2850) TPX2 PF06886.11 ORX46973.1 - 0.22 11.8 4.0 0.39 11.0 4.0 1.3 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) DUF3450 PF11932.8 ORX46973.1 - 0.43 9.8 7.9 0.74 9.1 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HemX PF04375.14 ORX46973.1 - 0.56 9.4 3.1 0.84 8.9 3.1 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Proteasome_A_N PF10584.9 ORX46973.1 - 0.56 9.9 3.2 81 3.0 0.1 3.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Sec5 PF15469.6 ORX46973.1 - 0.73 9.6 4.7 1.1 9.0 4.7 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec5 ZapB PF06005.12 ORX46973.1 - 1.7 9.1 6.9 16 6.0 6.9 2.2 1 1 0 1 1 1 0 Cell division protein ZapB YlqD PF11068.8 ORX46973.1 - 2.5 8.5 6.2 5.3 7.4 6.2 1.4 1 0 0 1 1 1 0 YlqD protein CENP-F_leu_zip PF10473.9 ORX46973.1 - 6.4 6.8 9.1 15 5.6 9.1 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AMP-binding PF00501.28 ORX46974.1 - 1.8e-97 326.7 0.0 2.1e-97 326.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX46974.1 - 7.3e-26 91.0 0.1 2e-25 89.6 0.1 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ORX46974.1 - 7.5e-18 64.2 0.2 2.7e-17 62.4 0.1 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus DDHD PF02862.17 ORX46975.1 - 3.4e-51 174.5 5.3 2.4e-50 171.8 0.0 2.5 2 1 1 3 3 3 1 DDHD domain WWE PF02825.20 ORX46975.1 - 1.4e-05 25.6 0.1 0.046 14.3 0.0 2.7 1 1 1 2 2 2 2 WWE domain DUF4746 PF15928.5 ORX46975.1 - 0.42 10.0 4.8 9.6 5.5 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF327 PF03885.13 ORX46975.1 - 0.66 9.9 3.2 1.7 8.6 3.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF327) Proteasome PF00227.26 ORX46976.1 - 1e-38 132.7 0.0 1.2e-38 132.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF4954 PF16314.5 ORX46976.1 - 0.03 12.5 0.0 0.035 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Chalcone_2 PF16035.5 ORX46977.1 - 3.6e-32 111.8 1.4 4.9e-31 108.1 1.4 2.0 1 1 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 ORX46977.1 - 1.6e-08 34.9 0.2 0.0018 18.4 0.0 2.1 2 0 0 2 2 2 2 Chalcone isomerase-like Chalcone PF02431.15 ORX46977.1 - 0.00017 21.0 0.0 0.00022 20.7 0.0 1.1 1 0 0 1 1 1 1 Chalcone-flavanone isomerase Isy1 PF06246.12 ORX46978.1 - 1.4e-84 283.7 2.4 1.6e-84 283.5 2.4 1.0 1 0 0 1 1 1 1 Isy1-like splicing family TPR_5 PF12688.7 ORX46978.1 - 0.091 13.0 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat Coa1 PF08695.10 ORX46979.1 - 1.4e-23 82.9 0.0 1.8e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 CheW PF01584.19 ORX46979.1 - 0.16 11.6 0.0 0.78 9.4 0.0 2.0 2 0 0 2 2 2 0 CheW-like domain DUF2264 PF10022.9 ORX46981.1 - 3.5e-125 417.8 0.2 4.3e-125 417.5 0.2 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Vta1_C PF18097.1 ORX46981.1 - 0.22 11.2 0.3 0.56 9.9 0.3 1.7 2 0 0 2 2 2 0 Vta1 C-terminal domain Glyco_hydro_88 PF07470.13 ORX46982.1 - 3e-18 66.0 1.3 4.2e-18 65.5 1.3 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.13 ORX46982.1 - 0.0017 17.9 0.5 0.0076 15.8 0.1 2.0 2 0 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 ORX46982.1 - 0.012 14.1 1.5 0.062 11.8 0.3 2.0 1 1 1 2 2 2 0 Beta-L-arabinofuranosidase, GH127 Glyco_hydro_76 PF03663.14 ORX46982.1 - 3.3 7.1 9.9 0.18 11.3 2.2 2.5 2 1 1 3 3 3 0 Glycosyl hydrolase family 76 Sugar_tr PF00083.24 ORX46983.1 - 4.1e-84 283.0 24.3 5.1e-84 282.7 24.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX46983.1 - 1.8e-29 102.8 23.2 1.8e-29 102.8 23.2 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX46983.1 - 0.0031 16.0 1.4 0.0031 16.0 1.4 2.3 2 1 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF4293 PF14126.6 ORX46983.1 - 8 6.7 9.9 0.71 10.1 4.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) DNA_pol_B PF00136.21 ORX46984.1 - 1.9e-97 326.9 0.0 2.4e-97 326.5 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX46984.1 - 5.1e-09 35.7 0.0 8.5e-09 35.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ORX46984.1 - 0.00066 20.1 6.1 0.0025 18.2 3.8 2.2 1 1 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Ribosomal_S15 PF00312.22 ORX46984.1 - 0.041 14.1 0.2 0.11 12.7 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S15 DNA_pol_B_2 PF03175.13 ORX46984.1 - 0.085 11.7 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral OrfB_Zn_ribbon PF07282.11 ORX46984.1 - 1.9 8.5 4.4 1.7 8.6 0.4 2.3 1 1 1 2 2 2 0 Putative transposase DNA-binding domain DNA_pol_B_exo1 PF03104.19 ORX46985.1 - 0.0012 18.1 0.0 0.002 17.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain NCD2 PF04905.13 ORX46986.1 - 1.2e-08 35.0 0.1 1.8e-08 34.4 0.1 1.3 1 1 0 1 1 1 1 NAB conserved region 2 (NCD2) NCD1 PF04904.13 ORX46986.1 - 4e-05 23.5 0.0 6.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) SAM_1 PF00536.30 ORX46986.1 - 0.05 14.0 0.0 0.092 13.2 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) WSK PF03832.13 ORX46987.1 - 0.00073 19.2 2.7 0.00073 19.2 2.7 2.8 2 0 0 2 2 2 1 WSK motif NAD_binding_2 PF03446.15 ORX46988.1 - 4.8e-22 78.8 0.1 8.7e-22 78.0 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ORX46988.1 - 5.9e-11 42.7 0.0 8.7e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 2-Hacid_dh_C PF02826.19 ORX46988.1 - 4.3e-05 22.9 0.1 6.9e-05 22.3 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX46988.1 - 5.6e-05 23.2 0.1 0.0001 22.4 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ORX46988.1 - 0.0033 18.0 0.1 0.0088 16.6 0.0 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DUF1858 PF08984.11 ORX46988.1 - 0.028 14.6 0.2 0.97 9.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) E1-E2_ATPase PF00122.20 ORX46989.1 - 2e-26 92.6 0.0 6.4e-26 91.0 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX46989.1 - 1.8e-10 41.4 0.0 4.8e-05 23.7 0.0 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX46989.1 - 0.0017 18.4 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX46989.1 - 0.002 17.8 0.3 0.0059 16.3 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus DUF4834 PF16118.5 ORX46989.1 - 0.1 13.6 0.1 0.43 11.6 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Hydrolase_3 PF08282.12 ORX46989.1 - 0.36 10.5 0.0 0.36 10.5 0.0 2.4 4 0 0 4 4 4 0 haloacid dehalogenase-like hydrolase PAZ_siRNAbind PF12212.8 ORX46990.1 - 0.099 12.5 0.3 5.6 6.8 0.1 2.4 2 0 0 2 2 2 0 PAZ domain DUF4296 PF14129.6 ORX46990.1 - 0.13 12.9 0.7 0.59 10.8 0.2 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4296) Pro_isomerase PF00160.21 ORX46991.1 - 8.8e-47 159.3 0.0 2.4e-46 157.9 0.0 1.8 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 ORX46991.1 - 6.7e-08 33.1 0.1 0.02 15.8 0.0 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX46991.1 - 0.002 18.4 0.0 0.55 10.6 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX46991.1 - 0.061 12.0 0.5 0.45 9.1 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cauli_VI PF01693.16 ORX46992.1 - 4e-20 71.8 4.4 7.2e-20 71.0 4.4 1.4 1 0 0 1 1 1 1 Caulimovirus viroplasmin RNase_H PF00075.24 ORX46992.1 - 0.01 16.0 1.4 0.012 15.8 0.2 1.7 2 1 1 3 3 3 0 RNase H Methyltransf_11 PF08241.12 ORX46993.1 - 5e-12 46.3 0.0 1.1e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX46993.1 - 1e-11 45.4 0.0 2.2e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX46993.1 - 1.4e-11 44.4 0.1 7.9e-11 42.0 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX46993.1 - 5.6e-11 42.5 0.0 1e-10 41.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX46993.1 - 8.7e-11 42.4 0.0 2.6e-10 40.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Arrestin_N PF00339.29 ORX46993.1 - 4.3e-07 30.1 0.0 9.6e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain MetW PF07021.12 ORX46993.1 - 0.00016 21.4 0.0 0.003 17.2 0.0 2.3 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW VP4_haemagglut PF00426.18 ORX46993.1 - 0.026 14.7 0.1 0.17 12.1 0.0 2.3 3 0 0 3 3 3 0 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain Amidohydro_2 PF04909.14 ORX46994.1 - 1.5e-23 84.0 0.0 7.4e-23 81.7 0.0 1.8 1 1 1 2 2 2 1 Amidohydrolase Phe_ZIP PF08916.11 ORX46994.1 - 0.025 15.3 0.0 0.047 14.4 0.0 1.4 1 0 0 1 1 1 0 Phenylalanine zipper ABC1 PF03109.16 ORX46995.1 - 6.5e-30 103.7 0.0 1.6e-29 102.4 0.0 1.7 1 0 0 1 1 1 1 ABC1 family WaaY PF06176.11 ORX46995.1 - 0.00028 20.6 0.1 0.0012 18.5 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide core biosynthesis protein (WaaY) APH PF01636.23 ORX46995.1 - 0.003 17.5 0.0 0.015 15.2 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Inj_translocase PF16928.5 ORX46995.1 - 0.021 14.3 0.1 0.74 9.2 0.1 2.4 2 0 0 2 2 2 0 DNA/protein translocase of phage P22 injectosome Pkinase_fungal PF17667.1 ORX46995.1 - 0.086 11.6 0.6 0.12 11.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase GTP_EFTU PF00009.27 ORX46996.1 - 1.3e-55 188.0 0.0 2.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX46996.1 - 7.2e-42 142.2 0.0 1.5e-41 141.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX46996.1 - 1.7e-14 53.9 1.2 1.7e-14 53.9 1.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX46996.1 - 0.00066 19.8 0.1 0.014 15.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Myb_DNA-binding PF00249.31 ORX46997.1 - 7.9e-19 67.6 0.5 1.1e-08 35.1 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX46997.1 - 1.5e-12 47.5 0.2 6e-05 23.2 0.1 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 ORX46997.1 - 4.7e-07 29.8 0.0 0.00094 19.2 0.0 2.5 2 1 0 2 2 2 2 SLIDE Nop16 PF09420.10 ORX46997.1 - 0.04 14.0 0.1 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 Ribosome biogenesis protein Nop16 Glyco_transf_24 PF18404.1 ORX46997.1 - 0.06 12.7 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 Glucosyltransferase 24 SQS_PSY PF00494.19 ORX46998.1 - 1.4e-32 113.2 0.1 2.2e-32 112.6 0.1 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF4131 PF13567.6 ORX46998.1 - 2.2 7.9 10.2 0.42 10.2 0.5 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Acetyltransf_1 PF00583.25 ORX46999.1 - 4.8e-11 42.9 0.0 5.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX46999.1 - 6.5e-10 39.0 0.1 2.7e-09 37.1 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX46999.1 - 9.6e-09 35.6 0.1 3.8e-08 33.7 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX46999.1 - 1.5e-07 31.6 0.0 2.8e-07 30.7 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX46999.1 - 8e-07 28.9 0.0 1.5e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ORX46999.1 - 0.0002 21.4 0.0 0.00039 20.5 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ORX46999.1 - 0.0016 18.4 0.0 0.0034 17.3 0.0 1.6 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase GNAT_acetyltran PF12746.7 ORX46999.1 - 0.0021 17.7 0.0 0.0021 17.7 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase CENP-T_C PF15511.6 ORX47000.1 - 1.6e-08 34.6 0.0 2e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ORX47000.1 - 3.9e-05 23.7 0.1 5.2e-05 23.3 0.1 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CENP-S PF15630.6 ORX47000.1 - 6.2e-05 23.3 0.0 8.1e-05 22.9 0.0 1.3 1 1 0 1 1 1 1 CENP-S protein Histone PF00125.24 ORX47000.1 - 0.00014 22.2 0.1 0.00017 21.9 0.1 1.2 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX47000.1 - 0.00024 21.3 0.1 0.00042 20.5 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX47000.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX47000.1 - 0.039 13.9 0.0 0.06 13.4 0.0 1.2 1 0 0 1 1 1 0 Bromodomain associated TFIID_20kDa PF03847.13 ORX47000.1 - 0.11 13.0 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A UPF0137 PF03677.13 ORX47000.1 - 0.14 11.9 0.1 0.17 11.7 0.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) Histone PF00125.24 ORX47001.1 - 8.6e-53 178.2 2.6 9.5e-53 178.0 2.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX47001.1 - 2.3e-05 24.7 0.0 3.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX47001.1 - 2.6e-05 24.3 0.5 4.8e-05 23.4 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ORX47001.1 - 5.5e-05 23.8 1.2 6.6e-05 23.5 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ORX47001.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX47001.1 - 0.059 13.5 0.1 0.094 12.8 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX47001.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Histone_H2A_C PF16211.5 ORX47002.1 - 1.1e-20 73.0 1.4 2e-20 72.2 1.4 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 ORX47002.1 - 6.5e-18 65.4 0.0 8.4e-18 65.0 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX47002.1 - 0.0008 19.6 0.0 0.0011 19.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX47003.1 - 6.8e-24 84.7 0.8 8.9e-24 84.3 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX47003.1 - 1.2e-06 28.7 0.1 2.9e-06 27.5 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ORX47003.1 - 0.00014 22.3 0.0 0.00025 21.5 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A YscO-like PF16789.5 ORX47003.1 - 0.014 15.4 0.3 0.016 15.2 0.3 1.1 1 0 0 1 1 1 0 YscO-like protein DUF1018 PF06252.12 ORX47003.1 - 0.016 16.2 0.4 0.021 15.8 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) CENP-W PF15510.6 ORX47003.1 - 0.038 14.2 0.0 0.054 13.7 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein RP-C PF03428.13 ORX47003.1 - 0.043 13.5 0.6 3.5 7.3 0.0 1.9 1 1 1 2 2 2 0 Replication protein C N-terminal domain DUF3915 PF13054.6 ORX47003.1 - 0.16 12.0 0.0 0.2 11.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) TMEM164 PF14808.6 ORX47004.1 - 3.1e-21 75.9 7.6 3.9e-21 75.5 7.6 1.1 1 0 0 1 1 1 1 TMEM164 family Flavodoxin_1 PF00258.25 ORX47005.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin Na_Ca_ex PF01699.24 ORX47006.1 - 1.9e-50 170.8 40.7 2.8e-27 95.5 13.6 2.5 2 0 0 2 2 2 2 Sodium/calcium exchanger protein CRA PF06589.11 ORX47006.1 - 0.11 12.6 0.0 0.36 11.0 0.0 1.9 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Ilar_coat PF01787.16 ORX47006.1 - 0.37 10.6 1.7 0.62 9.8 1.7 1.3 1 0 0 1 1 1 0 Ilarvirus coat protein Tmemb_9 PF05434.11 ORX47006.1 - 1.7 8.6 4.8 8 6.3 0.1 3.2 3 0 0 3 3 3 0 TMEM9 RRM_1 PF00076.22 ORX47007.1 - 6.5e-10 38.7 2.5 9.4e-09 35.0 0.2 3.2 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ORX47007.1 - 0.028 14.7 0.5 0.68 10.1 0.1 2.4 1 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Filo_VP35 PF02097.15 ORX47007.1 - 0.097 11.7 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Filoviridae VP35 Nup35_RRM_2 PF14605.6 ORX47007.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-C2H2 PF00096.26 ORX47008.1 - 6.5e-06 26.3 15.5 0.00023 21.4 0.9 3.3 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX47008.1 - 0.0001 22.5 0.8 0.0001 22.5 0.8 4.5 4 0 0 4 4 4 1 Zinc-finger double domain FOXP-CC PF16159.5 ORX47008.1 - 0.00023 21.7 1.4 0.77 10.4 0.1 2.8 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX47008.1 - 0.02 15.7 12.1 0.19 12.7 0.5 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger FANCL_C PF11793.8 ORX47008.1 - 0.17 12.1 2.1 0.72 10.1 0.4 2.3 2 0 0 2 2 2 0 FANCL C-terminal domain zf_C2H2_ZHX PF18387.1 ORX47008.1 - 0.19 11.4 3.7 0.22 11.2 0.6 2.3 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 ORX47008.1 - 2.1 8.4 7.2 3.8 7.6 0.1 3.3 2 1 0 2 2 2 0 C2H2-type zinc finger Ras PF00071.22 ORX47009.1 - 2.1e-60 203.0 0.1 2.5e-60 202.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX47009.1 - 1.1e-35 122.5 0.1 2.3e-35 121.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX47009.1 - 3.6e-12 46.1 0.0 4.2e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX47009.1 - 2.9e-05 24.1 0.1 0.2 11.6 0.0 2.3 1 1 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX47009.1 - 3.5e-05 23.8 0.0 7.4e-05 22.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX47009.1 - 4.4e-05 22.9 0.0 5.3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ORX47009.1 - 0.001 19.5 0.2 0.0025 18.2 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 ORX47009.1 - 0.0047 16.5 0.1 0.015 14.8 0.1 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 ORX47009.1 - 0.014 14.8 0.0 0.029 13.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 ORX47009.1 - 0.064 12.7 0.1 0.17 11.3 0.1 1.8 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 ORX47009.1 - 0.11 12.8 0.1 1.1 9.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain G-alpha PF00503.20 ORX47009.1 - 0.15 11.2 0.0 0.33 10.1 0.0 1.6 1 1 0 1 1 1 0 G-protein alpha subunit Septin PF00735.18 ORX47009.1 - 0.18 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 Septin SNF2_N PF00176.23 ORX47010.1 - 3.7e-73 246.3 0.2 9.9e-73 244.8 0.2 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 ORX47010.1 - 1e-39 135.1 4.0 1e-39 135.1 4.0 2.9 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 ORX47010.1 - 3e-26 92.3 11.7 3e-26 92.3 11.7 3.6 4 0 0 4 4 3 1 HAND Helicase_C PF00271.31 ORX47010.1 - 1.5e-18 67.2 0.0 6.2e-18 65.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX47010.1 - 7.1e-11 42.4 0.0 7.1e-11 42.4 0.0 3.6 4 1 0 4 4 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX47010.1 - 0.00041 19.6 0.0 0.0017 17.6 0.0 2.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 ORX47010.1 - 0.0062 16.3 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Myb_DNA-binding PF00249.31 ORX47010.1 - 0.011 15.9 3.4 1.2 9.4 0.0 3.3 3 0 0 3 3 2 0 Myb-like DNA-binding domain AAA_14 PF13173.6 ORX47010.1 - 0.018 15.1 0.0 0.018 15.1 0.0 3.3 4 0 0 4 4 4 0 AAA domain DBINO PF13892.6 ORX47010.1 - 0.04 14.3 0.1 0.04 14.3 0.1 5.1 5 0 0 5 5 5 0 DNA-binding domain AAA_22 PF13401.6 ORX47010.1 - 0.064 13.5 0.0 0.28 11.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 ORX47011.1 - 1.1e-13 51.5 1.1 4e-12 46.5 0.2 3.0 2 1 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 ORX47011.1 - 9.4e-06 26.1 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain PPI_Ypi1 PF07491.11 ORX47011.1 - 0.15 11.9 0.2 0.29 11.0 0.2 1.4 1 0 0 1 1 1 0 Protein phosphatase inhibitor A_deaminase PF00962.22 ORX47012.1 - 4.6e-25 88.7 0.0 5.8e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase MIF4G PF02854.19 ORX47013.1 - 3.8e-70 235.8 10.8 3.2e-36 125.0 0.0 3.6 3 0 0 3 3 3 3 MIF4G domain Upf2 PF04050.14 ORX47013.1 - 5.8e-37 127.5 13.1 5.8e-37 127.5 13.1 2.9 4 0 0 4 4 4 1 Up-frameshift suppressor 2 ORC4_C PF14629.6 ORX47013.1 - 0.059 12.7 0.1 0.31 10.4 0.0 2.3 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 4 C-terminus Adap_comp_sub PF00928.21 ORX47014.1 - 1.5e-86 290.1 0.0 1.8e-86 289.8 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX47014.1 - 1.1e-05 25.4 0.9 1.8e-05 24.7 0.9 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 ORX47014.1 - 0.11 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain CHCH PF06747.13 ORX47015.1 - 6e-10 39.0 6.3 8.1e-10 38.6 6.3 1.2 1 0 0 1 1 1 1 CHCH domain Pet191_N PF10203.9 ORX47015.1 - 0.00043 20.5 5.3 0.0015 18.8 5.3 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 CX9C PF16860.5 ORX47015.1 - 0.0012 18.8 4.3 0.0019 18.2 4.3 1.3 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, NDUF_B7 PF05676.13 ORX47015.1 - 0.0013 18.4 1.2 0.0016 18.1 1.2 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX17 PF05051.13 ORX47015.1 - 0.0098 16.2 4.2 0.31 11.4 0.6 2.2 1 1 1 2 2 2 2 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 ORX47015.1 - 0.027 14.5 4.9 0.045 13.8 4.9 1.4 1 1 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like GCK PF07802.11 ORX47015.1 - 0.064 13.7 2.5 0.17 12.3 2.5 1.6 1 1 1 2 2 2 0 GCK domain UPF0203 PF05254.12 ORX47015.1 - 0.16 12.2 3.4 1.3 9.4 0.3 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0203) PRP38_assoc PF12871.7 ORX47019.1 - 0.00024 21.7 23.2 0.00034 21.2 23.2 1.2 1 0 0 1 1 1 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.11 ORX47019.1 - 0.011 15.7 7.4 0.016 15.2 7.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Cytomega_UL84 PF06284.11 ORX47019.1 - 0.035 12.6 0.2 0.029 12.9 0.2 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Rrn6 PF10214.9 ORX47019.1 - 0.059 11.9 8.4 0.074 11.5 8.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor V_ATPase_I PF01496.19 ORX47019.1 - 0.12 10.3 0.3 0.15 9.9 0.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 ORX47019.1 - 0.19 10.9 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ORX47019.1 - 0.22 9.8 7.2 0.24 9.7 7.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ORX47019.1 - 0.29 9.8 1.1 0.38 9.5 1.1 1.2 1 0 0 1 1 1 0 Presenilin RSB_motif PF16294.5 ORX47019.1 - 1.5 9.2 19.9 2.2 8.6 19.9 1.3 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif DUF2828 PF11443.8 ORX47019.1 - 1.7 6.7 5.7 2 6.4 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Atrophin-1 PF03154.15 ORX47019.1 - 5.8 5.1 44.9 0.09 11.1 25.5 2.0 1 1 1 2 2 2 0 Atrophin-1 family DUF3915 PF13054.6 ORX47019.1 - 6.4 6.8 35.6 9.2 6.3 16.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3915) DUF2058 PF09831.9 ORX47019.1 - 7.4 6.7 8.8 11 6.1 8.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) PB1 PF00564.24 ORX47021.1 - 3.5e-11 42.9 0.1 8.8e-11 41.6 0.1 1.7 1 0 0 1 1 1 1 PB1 domain TPR_1 PF00515.28 ORX47021.1 - 5e-10 38.8 0.2 5e-05 22.9 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX47021.1 - 1.5e-09 37.3 0.1 0.0044 17.0 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX47021.1 - 0.00016 21.7 0.6 0.012 15.7 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX47021.1 - 0.00019 21.4 0.0 0.022 14.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX47021.1 - 0.00088 18.9 0.0 0.0072 16.0 0.0 2.4 1 1 1 2 2 2 1 TPR repeat TPR_16 PF13432.6 ORX47021.1 - 0.01 16.4 0.0 0.04 14.6 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX47021.1 - 0.036 14.9 0.0 0.13 13.1 0.0 2.0 2 0 0 2 2 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX47021.1 - 0.038 14.4 0.0 2.1 8.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX47021.1 - 0.053 13.8 0.3 4.1 7.8 0.0 3.2 2 2 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX47021.1 - 0.13 12.9 0.0 40 5.2 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ATP_bind_1 PF03029.17 ORX47022.1 - 3.3e-79 266.1 0.2 4.3e-79 265.7 0.2 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ORX47022.1 - 2.2e-06 27.4 0.5 5.8e-05 22.7 0.5 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ORX47022.1 - 4.9e-05 22.4 0.1 0.051 12.5 0.0 2.2 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB G-alpha PF00503.20 ORX47022.1 - 9.3e-05 21.7 0.6 0.091 11.9 0.0 2.6 2 1 1 3 3 3 2 G-protein alpha subunit AAA_33 PF13671.6 ORX47022.1 - 0.00019 21.6 0.1 0.00077 19.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain FeoB_N PF02421.18 ORX47022.1 - 0.00021 20.9 0.0 0.0068 15.9 0.0 2.8 2 1 1 3 3 3 1 Ferrous iron transport protein B cobW PF02492.19 ORX47022.1 - 0.00023 20.8 0.1 0.74 9.4 0.0 2.5 2 1 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ORX47022.1 - 0.00024 20.9 0.2 0.0014 18.4 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX47022.1 - 0.0003 21.2 0.0 0.0018 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX47022.1 - 0.00067 19.7 0.0 0.0044 17.1 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ORX47022.1 - 0.0015 18.8 0.0 0.0076 16.5 0.0 2.3 3 1 0 3 3 2 1 AAA domain AAA_23 PF13476.6 ORX47022.1 - 0.0022 18.5 0.1 0.38 11.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 ORX47022.1 - 0.0024 17.5 0.0 0.034 13.8 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NB-ARC PF00931.22 ORX47022.1 - 0.0047 16.1 0.3 0.013 14.7 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain Arf PF00025.21 ORX47022.1 - 0.0048 16.4 0.0 1.6 8.1 0.0 2.7 2 1 0 2 2 2 1 ADP-ribosylation factor family NACHT PF05729.12 ORX47022.1 - 0.005 16.8 0.0 0.014 15.3 0.0 1.7 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 ORX47022.1 - 0.0056 16.4 0.1 0.013 15.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain SHE3 PF17078.5 ORX47022.1 - 0.0059 16.4 0.4 0.022 14.5 0.5 1.8 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 AAA_18 PF13238.6 ORX47022.1 - 0.011 16.3 0.2 0.11 13.1 0.0 2.4 2 1 1 3 3 3 0 AAA domain PduV-EutP PF10662.9 ORX47022.1 - 0.016 15.0 0.1 0.4 10.4 0.0 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.18 ORX47022.1 - 0.02 14.7 0.0 0.053 13.2 0.0 1.8 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family FtsK_SpoIIIE PF01580.18 ORX47022.1 - 0.021 14.2 1.8 0.93 8.8 0.1 2.9 2 1 1 3 3 3 0 FtsK/SpoIIIE family AAA_7 PF12775.7 ORX47022.1 - 0.021 14.3 0.6 0.047 13.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_19 PF13245.6 ORX47022.1 - 0.027 14.8 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain CLP1_P PF16575.5 ORX47022.1 - 0.07 12.9 0.0 5.6 6.7 0.0 2.7 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Cgr1 PF03879.14 ORX47022.1 - 0.077 13.4 2.4 0.13 12.6 2.4 1.2 1 0 0 1 1 1 0 Cgr1 family SRPRB PF09439.10 ORX47022.1 - 0.086 12.3 0.7 3.5 7.0 0.0 2.5 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Roc PF08477.13 ORX47022.1 - 0.13 12.5 0.0 4.6 7.5 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase E3_UbLigase_EDD PF11547.8 ORX47023.1 - 0.064 13.0 0.8 0.13 12.0 0.1 1.9 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD BRAP2 PF07576.12 ORX47025.1 - 0.08 13.2 0.0 0.086 13.1 0.0 1.1 1 0 0 1 1 1 0 BRCA1-associated protein 2 Pkinase PF00069.25 ORX47026.1 - 8.3e-50 169.6 0.0 1.1e-49 169.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47026.1 - 1.1e-24 87.1 0.0 1.5e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 ORX47026.1 - 1.2e-05 25.2 1.1 4.7e-05 23.4 0.4 2.3 2 1 0 2 2 2 1 PX domain Kinase-like PF14531.6 ORX47026.1 - 0.14 11.4 0.3 0.52 9.6 0.0 2.1 2 1 0 2 2 2 0 Kinase-like Skp1 PF01466.19 ORX47027.1 - 1.2e-28 98.9 1.9 4.2e-28 97.2 0.7 2.3 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ORX47027.1 - 5.8e-26 90.4 0.6 4.7e-25 87.5 0.0 2.4 2 1 1 3 3 3 1 Skp1 family, tetramerisation domain RPN6_N PF18055.1 ORX47027.1 - 0.005 17.2 0.0 0.68 10.3 0.0 2.2 2 0 0 2 2 2 2 26S proteasome regulatory subunit RPN6 N-terminal domain CofC PF01983.16 ORX47027.1 - 0.0067 15.6 0.4 0.0083 15.3 0.4 1.2 1 0 0 1 1 1 1 Guanylyl transferase CofC like DUF5354 PF17305.2 ORX47028.1 - 0.056 13.6 0.0 0.066 13.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5354) OrfB_Zn_ribbon PF07282.11 ORX47030.1 - 7.2e-05 22.6 3.8 0.00013 21.8 3.8 1.6 1 1 0 1 1 1 1 Putative transposase DNA-binding domain BCIP PF13862.6 ORX47032.1 - 7e-67 225.2 0.6 8.9e-67 224.9 0.6 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein DUF678 PF05077.12 ORX47035.1 - 0.016 15.3 0.3 0.022 14.9 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF678) zinc_ribbon_9 PF14369.6 ORX47035.1 - 0.032 14.5 0.3 0.07 13.4 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon Lar_restr_allev PF14354.6 ORX47035.1 - 0.036 14.4 0.8 0.059 13.8 0.8 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar OrfB_Zn_ribbon PF07282.11 ORX47035.1 - 0.057 13.4 3.1 0.21 11.5 3.1 2.0 1 1 0 1 1 1 0 Putative transposase DNA-binding domain TRAM1 PF08390.11 ORX47036.1 - 0.11 12.1 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 TRAM1-like protein DEK_C PF08766.11 ORX47039.1 - 0.09 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 DEK C terminal domain V-set_2 PF15910.5 ORX47040.1 - 0.0042 17.2 0.2 0.005 16.9 0.2 1.1 1 0 0 1 1 1 1 ICOS V-set domain SSP160 PF06933.11 ORX47040.1 - 0.29 9.3 4.3 0.3 9.2 4.3 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RSRP PF17069.5 ORX47040.1 - 0.32 10.5 10.1 0.38 10.3 10.1 1.0 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 V-set_2 PF15910.5 ORX47041.1 - 0.0042 17.2 0.2 0.005 16.9 0.2 1.1 1 0 0 1 1 1 1 ICOS V-set domain SSP160 PF06933.11 ORX47041.1 - 0.29 9.3 4.3 0.3 9.2 4.3 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RSRP PF17069.5 ORX47041.1 - 0.32 10.5 10.1 0.38 10.3 10.1 1.0 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Phosphorylase PF00343.20 ORX47047.1 - 1.3e-295 982.3 0.0 1.7e-295 981.9 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Lar_N PF09861.9 ORX47047.1 - 0.041 13.1 0.0 0.078 12.1 0.0 1.4 1 0 0 1 1 1 0 Lactate racemase N-terminal domain PseudoU_synth_1 PF01416.20 ORX47048.1 - 1.5e-29 102.6 0.0 7.1e-25 87.6 0.0 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase GA-like PF17573.2 ORX47048.1 - 0.11 12.5 0.2 0.19 11.6 0.2 1.4 1 0 0 1 1 1 0 GA-like domain Mito_carr PF00153.27 ORX47049.1 - 9.9e-65 214.5 8.0 5.7e-22 77.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ORX47049.1 - 2.5e-13 50.3 2.5 9.3e-06 26.0 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX47049.1 - 1.2e-12 46.7 4.7 0.16 12.0 1.6 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ORX47049.1 - 2.8e-10 39.0 1.5 0.0023 17.4 0.9 4.3 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ORX47049.1 - 2.4e-08 33.7 0.4 0.0066 16.3 0.1 3.3 3 0 0 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX47049.1 - 0.0024 18.2 0.1 0.48 10.8 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ORX47049.1 - 0.0027 17.5 0.0 0.26 11.2 0.0 2.9 2 1 1 3 3 3 1 EF hand EF-hand_5 PF13202.6 ORX47049.1 - 0.0029 17.0 0.3 0.97 9.0 0.6 2.6 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 ORX47049.1 - 0.045 13.7 0.4 0.36 10.8 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Peptidase_U4 PF03419.13 ORX47050.1 - 0.0058 15.9 0.1 0.0086 15.4 0.1 1.1 1 0 0 1 1 1 1 Sporulation factor SpoIIGA DUF4010 PF13194.6 ORX47050.1 - 0.0097 15.6 0.2 0.015 15.0 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4010) SLAC1 PF03595.17 ORX47050.1 - 0.011 15.1 0.5 0.015 14.6 0.5 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel BRI3BP PF14965.6 ORX47050.1 - 0.051 13.1 1.7 0.095 12.2 1.7 1.4 1 1 0 1 1 1 0 Negative regulator of p53/TP53 DUF2254 PF10011.9 ORX47050.1 - 1.7 7.4 4.4 0.3 9.9 0.3 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2254) AAA PF00004.29 ORX47051.1 - 7.8e-18 65.2 0.0 2e-17 63.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX47051.1 - 1.6e-05 25.3 0.0 5.7e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_25 PF13481.6 ORX47051.1 - 3.6e-05 23.4 1.0 0.0023 17.5 0.1 2.7 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ORX47051.1 - 0.0018 18.3 0.5 0.0089 16.0 0.0 2.3 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ORX47051.1 - 0.0031 16.8 0.0 0.0054 16.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 ORX47051.1 - 0.0068 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ORX47051.1 - 0.013 15.8 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase DUF815 PF05673.13 ORX47051.1 - 0.022 13.9 0.0 0.041 13.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 ORX47051.1 - 0.046 13.5 0.2 0.73 9.6 0.0 2.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain Bac_DnaA PF00308.18 ORX47051.1 - 0.063 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial dnaA protein DUF1737 PF08410.10 ORX47051.1 - 0.067 13.1 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) AAA_11 PF13086.6 ORX47051.1 - 0.075 12.8 0.0 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX47051.1 - 0.075 12.7 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX47051.1 - 0.12 12.7 0.1 0.41 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain Aminotran_1_2 PF00155.21 ORX47052.1 - 6.5e-37 127.5 0.0 8.2e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX47052.1 - 0.00056 18.5 0.0 0.00091 17.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF3051 PF11252.8 ORX47052.1 - 0.075 12.7 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) PH PF00169.29 ORX47053.1 - 4.1e-08 33.7 0.1 1.2e-07 32.1 0.1 1.9 1 0 0 1 1 1 1 PH domain STN PF07660.14 ORX47053.1 - 0.63 9.9 1.8 1.7 8.5 0.3 2.3 2 0 0 2 2 2 0 Secretin and TonB N terminus short domain DUF2420 PF10336.9 ORX47053.1 - 4.1 7.5 10.4 6.5 6.8 0.2 3.4 3 1 0 4 4 4 0 Protein of unknown function (DUF2420) F-box PF00646.33 ORX47054.1 - 1e-05 25.3 0.9 3.4e-05 23.6 0.9 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX47054.1 - 0.063 13.2 0.3 0.063 13.2 0.3 1.9 2 0 0 2 2 2 0 F-box-like DLH PF01738.18 ORX47056.1 - 6e-18 65.2 0.1 8.2e-17 61.5 0.0 2.2 2 1 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 ORX47056.1 - 0.052 13.5 0.0 0.15 11.9 0.0 1.7 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal ScdA_N PF04405.14 ORX47056.1 - 0.089 12.5 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) MBOAT_2 PF13813.6 ORX47057.1 - 1.3e-10 41.4 0.1 3.4e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family ALS_ss_C PF10369.9 ORX47058.1 - 4.6e-19 68.4 0.1 4.5e-17 62.0 0.0 2.7 3 0 0 3 3 3 1 Small subunit of acetolactate synthase ACT PF01842.25 ORX47058.1 - 6.1e-13 48.3 0.1 1.1e-12 47.4 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 ORX47058.1 - 1.4e-08 34.4 0.0 2.9e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain Macro PF01661.21 ORX47059.1 - 9.8e-39 132.0 0.1 1.6e-38 131.4 0.1 1.3 1 0 0 1 1 1 1 Macro domain Inositol_P PF00459.25 ORX47060.1 - 3.6e-42 144.8 1.3 1.2e-29 103.7 0.1 2.4 2 1 0 2 2 2 2 Inositol monophosphatase family PCI PF01399.27 ORX47061.1 - 1.7e-12 47.7 1.0 4.3e-12 46.5 0.0 2.2 3 1 0 3 3 3 1 PCI domain Rpn9_C PF18261.1 ORX47061.1 - 0.00094 18.7 0.6 0.0041 16.7 0.6 2.1 1 0 0 1 1 1 1 Rpn9 C-terminal helix COX5A PF02284.16 ORX47061.1 - 0.11 12.5 0.0 0.3 11.1 0.0 1.8 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va DUF5082 PF16888.5 ORX47061.1 - 0.18 12.1 1.0 0.68 10.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) Glyco_hydro_3_C PF01915.22 ORX47062.1 - 1.4e-59 201.5 0.0 1.9e-59 201.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 ORX47062.1 - 1.1e-36 126.8 0.0 1.6e-36 126.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 ORX47062.1 - 2.4e-22 78.8 0.0 5.3e-22 77.7 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain ILVD_EDD PF00920.21 ORX47063.1 - 2.6e-210 699.4 0.2 3.1e-210 699.2 0.2 1.1 1 0 0 1 1 1 1 Dehydratase family MOZ_SAS PF01853.18 ORX47064.1 - 1.4e-67 226.8 0.1 1.9e-67 226.4 0.1 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX47064.1 - 4.9e-13 48.5 0.3 2.9e-12 46.0 0.2 2.2 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 ORX47064.1 - 0.1 13.0 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CAP_GLY PF01302.25 ORX47066.1 - 9.7e-18 64.0 0.1 1.7e-17 63.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain BTB PF00651.31 ORX47066.1 - 3.2e-08 33.8 0.0 2.2e-07 31.1 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain GET2 PF08690.10 ORX47067.1 - 9.8e-16 58.3 1.9 5.8e-10 39.3 0.1 2.2 2 0 0 2 2 2 2 GET complex subunit GET2 P22_AR_N PF10547.9 ORX47068.1 - 0.033 14.5 0.0 0.34 11.2 0.0 2.0 2 0 0 2 2 2 0 P22_AR N-terminal domain Inhibitor_I69 PF13734.6 ORX47068.1 - 0.07 13.6 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Spi protease inhibitor PAS_8 PF13188.7 ORX47068.1 - 0.11 12.5 0.0 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 PAS domain NMO PF03060.15 ORX47069.1 - 1.6e-60 205.2 0.7 2.8e-59 201.2 0.7 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ORX47069.1 - 7.1e-12 45.0 0.3 1.6e-05 24.1 0.3 2.2 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain TMP-TENI PF02581.17 ORX47069.1 - 0.0041 16.5 0.3 0.0071 15.7 0.3 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase Glu_synthase PF01645.17 ORX47069.1 - 0.0046 16.1 0.8 0.0093 15.1 0.8 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase ThiG PF05690.14 ORX47069.1 - 0.0057 16.0 0.8 0.012 14.9 0.2 1.9 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 ORX47069.1 - 0.0058 16.1 0.2 0.014 14.9 0.2 1.6 1 0 0 1 1 1 1 Histidine biosynthesis protein FMN_dh PF01070.18 ORX47069.1 - 0.012 14.6 1.8 0.026 13.6 1.9 1.6 1 1 0 1 1 1 0 FMN-dependent dehydrogenase NanE PF04131.14 ORX47069.1 - 0.016 14.4 0.8 0.027 13.7 0.2 1.8 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Glyco_trans_4_5 PF16994.5 ORX47069.1 - 0.09 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl-transferase family 4 Mito_carr PF00153.27 ORX47070.1 - 5.7e-30 103.1 1.1 5.9e-16 58.2 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein ABC_tran_CTD PF16326.5 ORX47071.1 - 0.016 15.5 0.4 0.062 13.6 0.2 2.0 1 1 1 2 2 2 0 ABC transporter C-terminal domain BSMAP PF12280.8 ORX47071.1 - 0.075 13.2 0.1 0.41 10.8 0.0 1.9 2 0 0 2 2 2 0 Brain specific membrane anchored protein IF4E PF01652.18 ORX47072.1 - 1.9e-60 203.2 0.3 2.3e-60 203.0 0.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E p450 PF00067.22 ORX47073.1 - 1.2e-91 307.9 0.0 1.4e-91 307.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 OrfB_Zn_ribbon PF07282.11 ORX47074.1 - 5.7e-05 23.0 5.0 0.00028 20.7 5.0 2.0 1 1 0 1 1 1 1 Putative transposase DNA-binding domain DAP10 PF07213.11 ORX47074.1 - 0.08 12.9 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 DAP10 membrane protein DAO PF01266.24 ORX47136.1 - 2.4e-52 178.7 0.0 3.6e-52 178.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ORX47136.1 - 3.6e-44 149.7 0.0 7.7e-44 148.6 0.0 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ORX47136.1 - 2.3e-10 40.2 0.4 0.00012 21.3 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.7 ORX47136.1 - 7.9e-08 32.1 1.0 5.5e-05 22.7 0.3 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 ORX47136.1 - 0.00017 20.8 0.4 0.076 12.1 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ORX47136.1 - 0.00028 20.2 1.5 0.0034 16.6 1.4 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX47136.1 - 0.00056 19.2 0.0 0.033 13.4 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 ORX47136.1 - 0.00065 19.9 3.1 0.0026 18.0 0.3 3.0 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX47136.1 - 0.012 14.9 0.2 0.34 10.1 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ORX47136.1 - 0.024 15.1 0.0 0.25 11.8 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 ORX47136.1 - 0.032 12.9 0.1 0.062 12.0 0.1 1.4 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 ORX47136.1 - 0.036 13.3 0.5 0.12 11.6 0.1 2.0 2 0 0 2 2 2 0 Thi4 family Pyr_redox PF00070.27 ORX47136.1 - 0.068 13.7 0.1 0.23 12.1 0.1 1.9 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MMACHC PF16690.5 ORX47136.1 - 0.075 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type C family Inj_translocase PF16928.5 ORX47136.1 - 0.32 10.4 1.9 0.73 9.2 1.9 1.5 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome WD40 PF00400.32 ORX47137.1 - 3e-30 103.8 12.3 2.1e-05 25.2 0.0 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX47137.1 - 6.4e-12 45.6 0.0 0.051 13.9 0.1 4.5 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX47137.1 - 0.0014 18.6 0.5 4 7.3 0.1 3.2 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Forkhead PF00250.18 ORX47138.1 - 6.4e-36 122.5 0.3 8.6e-36 122.1 0.3 1.2 1 0 0 1 1 1 1 Forkhead domain UCH PF00443.29 ORX47141.1 - 2.1e-29 102.8 0.0 4e-28 98.6 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX47141.1 - 2.3e-07 30.7 0.5 4.3e-05 23.2 0.1 2.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Chitin_synth_2 PF03142.15 ORX47142.1 - 6.5e-224 744.4 0.5 1.3e-195 651.0 0.3 2.1 1 1 1 2 2 2 2 Chitin synthase Myosin_head PF00063.21 ORX47142.1 - 2.1e-55 188.2 0.0 4.6e-55 187.1 0.0 1.6 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ORX47142.1 - 2.4e-13 50.0 0.1 8.9e-08 32.2 0.0 3.6 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_trans_2_3 PF13632.6 ORX47142.1 - 1.7e-10 41.2 1.4 1.7e-10 41.2 1.4 3.2 4 0 0 4 4 4 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX47142.1 - 1.9e-08 34.5 0.0 2e-07 31.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ORX47142.1 - 0.00015 21.6 0.0 0.0069 16.2 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX47142.1 - 0.00046 19.7 0.0 0.13 11.8 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 21 AAA_22 PF13401.6 ORX47142.1 - 0.078 13.3 0.0 6.1 7.1 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX47142.1 - 0.71 10.2 0.0 0.71 10.2 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain Tubulin PF00091.25 ORX47143.1 - 4.7e-55 186.9 0.0 7e-55 186.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX47143.1 - 8.1e-48 161.7 0.7 1.5e-47 160.9 0.7 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ORX47143.1 - 0.0037 17.0 0.0 0.0078 15.9 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain STIMATE PF12400.8 ORX47144.1 - 2.9e-16 60.2 1.7 2.9e-16 60.2 1.7 1.7 2 0 0 2 2 2 1 STIMATE family DUF3094 PF11293.8 ORX47144.1 - 2.2 8.1 6.0 15 5.4 0.2 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3094) Abhydrolase_3 PF07859.13 ORX47145.1 - 3e-25 89.3 0.0 5.1e-25 88.6 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX47145.1 - 8.6e-09 34.7 0.5 1e-07 31.2 0.5 2.2 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX47145.1 - 0.0091 15.5 0.0 0.024 14.1 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ORX47145.1 - 0.014 14.3 0.0 0.57 9.0 0.0 2.2 2 0 0 2 2 2 0 Carboxylesterase family BC10 PF06726.12 ORX47146.1 - 7.6e-14 51.7 9.5 1.1e-13 51.2 9.5 1.2 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 DUF4017 PF13209.6 ORX47146.1 - 0.044 13.7 0.6 0.089 12.7 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4017) MgsA_C PF12002.8 ORX47148.1 - 5.9e-59 198.8 0.0 9.3e-59 198.1 0.0 1.3 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 ORX47148.1 - 1.9e-25 89.0 1.2 4.3e-25 87.9 1.2 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 ORX47148.1 - 5.5e-16 59.2 0.0 1.1e-15 58.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX47148.1 - 3.6e-13 49.6 0.0 8.6e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 ORX47148.1 - 6.1e-06 26.3 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX47148.1 - 6.3e-06 26.7 0.9 0.03 14.7 0.1 2.8 2 1 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 ORX47148.1 - 1.3e-05 24.6 0.0 2.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 ORX47148.1 - 2.8e-05 24.2 0.0 0.0002 21.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX47148.1 - 7e-05 22.6 0.0 0.0037 17.0 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain zf-WRNIP1_ubi PF18279.1 ORX47148.1 - 0.00014 22.3 0.2 0.00034 21.0 0.2 1.7 1 0 0 1 1 1 1 Werner helicase-interacting protein 1 ubiquitin-binding domain AAA_19 PF13245.6 ORX47148.1 - 0.00067 20.0 0.4 0.13 12.6 0.1 2.3 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ORX47148.1 - 0.003 17.3 0.6 0.0094 15.7 0.0 1.9 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 ORX47148.1 - 0.0042 16.9 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ORX47148.1 - 0.0043 16.5 0.2 0.9 8.9 0.1 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ORX47148.1 - 0.0055 17.0 0.6 0.16 12.3 0.6 2.4 1 1 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 ORX47148.1 - 0.0081 16.3 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain Zeta_toxin PF06414.12 ORX47148.1 - 0.01 15.2 0.0 0.027 13.7 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 ORX47148.1 - 0.01 16.1 0.1 0.019 15.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ORX47148.1 - 0.013 15.6 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ORX47148.1 - 0.014 14.6 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 ORX47148.1 - 0.018 15.6 0.2 0.057 13.9 0.2 2.1 1 1 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 ORX47148.1 - 0.022 13.9 0.0 0.057 12.6 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 ORX47148.1 - 0.041 14.3 0.0 0.25 11.7 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 ORX47148.1 - 0.055 14.0 0.0 0.15 12.6 0.0 1.7 2 0 0 2 2 1 0 AAA domain SKI PF01202.22 ORX47148.1 - 0.065 13.3 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate kinase AAA_30 PF13604.6 ORX47148.1 - 0.066 12.9 0.1 0.25 11.0 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX47148.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ORX47148.1 - 0.097 12.6 0.0 0.2 11.6 0.0 1.5 1 1 0 1 1 1 0 Rad17 P-loop domain ATPase_2 PF01637.18 ORX47148.1 - 0.12 12.2 0.0 13 5.7 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea CPT PF07931.12 ORX47148.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 ORX47148.1 - 0.15 11.5 0.0 1.9 7.9 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein PRP21_like_P PF12230.8 ORX47148.1 - 0.19 11.6 0.2 0.36 10.7 0.2 1.4 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein Med11 PF10280.9 ORX47149.1 - 2.1e-08 34.7 0.4 2.5e-08 34.5 0.4 1.3 1 1 0 1 1 1 1 Mediator complex protein Sec7 PF01369.20 ORX47150.1 - 4.4e-33 114.5 0.1 9.5e-33 113.4 0.1 1.5 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ORX47150.1 - 1.3e-15 57.8 0.0 3.2e-12 46.9 0.0 2.8 3 0 0 3 3 3 2 Pleckstrin homology domain PH PF00169.29 ORX47150.1 - 9.2e-07 29.3 0.0 3.8e-05 24.1 0.0 2.5 2 0 0 2 2 2 1 PH domain Cu_amine_oxid PF01179.20 ORX47151.1 - 1.3e-155 518.4 3.1 1.6e-155 518.1 3.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 ORX47151.1 - 9.9e-18 64.4 0.1 2.4e-17 63.2 0.1 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 ORX47151.1 - 6.3e-07 29.5 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain F-box-like PF12937.7 ORX47152.1 - 0.0032 17.3 0.3 0.0032 17.3 0.3 2.1 2 0 0 2 2 2 1 F-box-like PNK3P PF08645.11 ORX47153.1 - 4.3e-59 198.8 0.1 2e-58 196.7 0.1 1.9 2 0 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ORX47153.1 - 9.8e-20 71.2 0.0 2.9e-17 63.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ORX47153.1 - 2.9e-08 33.5 0.1 0.0012 18.4 0.0 2.2 1 1 1 2 2 2 2 Chromatin associated protein KTI12 HAD_2 PF13419.6 ORX47153.1 - 0.0011 19.1 0.0 0.35 11.0 0.0 2.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 ORX47153.1 - 0.0013 19.2 0.1 0.2 12.2 0.0 2.6 2 1 1 3 3 3 1 AAA domain Hydrolase_6 PF13344.6 ORX47153.1 - 0.0034 17.4 0.4 0.13 12.4 0.1 3.0 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX47153.1 - 0.048 13.9 0.1 3.8 7.7 0.1 2.3 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Zeta_toxin PF06414.12 ORX47153.1 - 0.06 12.6 0.0 0.21 10.8 0.0 1.9 2 1 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 ORX47153.1 - 0.12 11.9 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX47153.1 - 0.14 12.4 0.0 0.42 10.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX47153.1 - 0.16 12.4 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ORX47153.1 - 0.17 12.4 0.0 0.34 11.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Golgin_A5 PF09787.9 ORX47154.1 - 0.13 11.7 10.7 0.25 10.8 10.7 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Nucleotid_trans PF03407.16 ORX47155.1 - 1.2e-25 90.7 0.0 1.7e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Sec7 PF01369.20 ORX47156.1 - 5.4e-31 107.7 0.1 2e-30 105.9 0.0 1.8 2 0 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 ORX47156.1 - 1.4e-29 102.8 0.0 9e-29 100.3 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ORX47156.1 - 0.00066 20.2 0.0 0.14 12.6 0.0 2.5 2 0 0 2 2 2 1 PH domain YCII PF03795.14 ORX47156.1 - 0.11 12.9 0.0 0.36 11.3 0.0 1.8 1 0 0 1 1 1 0 YCII-related domain Lzipper-MIP1 PF14389.6 ORX47156.1 - 0.46 10.8 2.3 1.6 9.1 1.8 2.4 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 UDPGP PF01704.18 ORX47157.1 - 3.4e-35 121.5 0.0 3.7e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Lac_bphage_repr PF06543.12 ORX47157.1 - 0.18 11.8 0.1 0.4 10.7 0.1 1.5 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Arrestin_N PF00339.29 ORX47158.1 - 7.2e-09 35.8 0.5 1.1e-07 32.0 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX47158.1 - 0.0016 18.9 0.0 0.0075 16.7 0.0 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 ORX47158.1 - 0.0058 16.3 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like UCH_1 PF13423.6 ORX47159.1 - 3.3e-80 270.1 4.7 5e-79 266.2 1.0 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 ORX47159.1 - 1.2e-22 81.2 0.0 2.3e-22 80.3 0.0 1.5 1 0 0 1 1 1 1 Exonuclease UCH PF00443.29 ORX47159.1 - 7e-07 29.0 0.0 2.9e-06 27.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ANAPC4_WD40 PF12894.7 ORX47159.1 - 0.13 12.6 0.0 1.8 8.9 0.0 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Phosphodiest PF01663.22 ORX47161.1 - 2.8e-10 40.3 2.7 0.00013 21.7 0.4 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Pkinase PF00069.25 ORX47162.1 - 5.4e-75 252.2 0.0 6.3e-75 251.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47162.1 - 8.6e-47 159.6 0.0 1.1e-46 159.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX47162.1 - 4.1e-07 29.6 0.0 1.7e-06 27.6 0.0 1.8 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX47162.1 - 0.0053 15.6 0.0 0.0072 15.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX47162.1 - 0.0093 15.9 1.5 0.11 12.4 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family FTA2 PF13095.6 ORX47162.1 - 0.049 13.3 0.4 0.15 11.7 0.4 1.8 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF3974 PF13120.6 ORX47162.1 - 0.063 13.4 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) YrbL-PhoP_reg PF10707.9 ORX47162.1 - 0.1 12.1 1.5 0.25 10.9 0.5 2.1 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL RRS1 PF04939.12 ORX47164.1 - 1.6e-59 200.4 4.3 1.6e-59 200.4 4.3 2.1 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) LTXXQ PF07813.12 ORX47164.1 - 0.46 11.2 11.5 0.15 12.8 8.4 1.8 2 0 0 2 2 2 0 LTXXQ motif family protein ATP_bind_1 PF03029.17 ORX47165.1 - 2.8e-88 295.8 0.1 2.6e-78 263.1 0.0 2.0 1 1 1 2 2 2 2 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 ORX47165.1 - 9.3e-05 22.3 0.0 0.00023 21.0 0.0 1.7 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_24 PF13479.6 ORX47165.1 - 0.0072 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_31 PF13614.6 ORX47165.1 - 0.013 15.4 1.0 3.5 7.5 0.0 2.6 2 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ORX47165.1 - 0.013 15.4 0.1 6 6.7 0.1 2.3 2 0 0 2 2 2 0 NTPase MeaB PF03308.16 ORX47165.1 - 0.016 14.2 0.0 0.033 13.2 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB CbiA PF01656.23 ORX47165.1 - 0.044 13.8 0.0 0.051 13.6 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain GTP_EFTU PF00009.27 ORX47165.1 - 0.07 12.7 0.6 8.3 5.9 0.0 2.4 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ORX47165.1 - 0.67 10.5 4.8 0.8 10.3 0.1 2.7 1 1 0 2 2 2 0 AAA domain PDZ_5 PF17817.1 ORX47166.1 - 0.004 17.4 0.1 0.0069 16.6 0.1 1.4 1 0 0 1 1 1 1 PDZ domain GFA PF04828.14 ORX47167.1 - 1.3e-21 76.8 1.6 1.7e-21 76.4 1.6 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme GFA PF04828.14 ORX47168.1 - 3.7e-17 62.5 1.2 4.9e-17 62.1 1.2 1.2 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_2 PF13240.6 ORX47168.1 - 0.71 9.7 7.2 0.9 9.3 0.5 2.7 2 1 0 2 2 2 0 zinc-ribbon domain WD40 PF00400.32 ORX47169.1 - 9.7e-18 64.2 0.2 0.053 14.4 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX47169.1 - 6.9e-15 55.1 0.0 0.0044 17.3 0.0 6.5 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX47169.1 - 0.0019 16.8 0.1 0.004 15.7 0.1 1.6 1 0 0 1 1 1 1 Cytochrome D1 heme domain Gmad1 PF10647.9 ORX47169.1 - 0.067 12.9 0.0 0.7 9.6 0.0 2.3 1 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain ASXH PF13919.6 ORX47170.1 - 5.5e-15 55.6 0.1 9.2e-15 54.9 0.1 1.3 1 0 0 1 1 1 1 Asx homology domain RAMA PF18755.1 ORX47170.1 - 0.0096 16.3 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 1 Restriction Enzyme Adenine Methylase Associated RE_BsaWI PF18643.1 ORX47170.1 - 0.12 12.3 0.4 0.21 11.5 0.4 1.4 1 0 0 1 1 1 0 BsaWI restriction endonuclease type 2 SNF2_N PF00176.23 ORX47171.1 - 2.3e-45 154.8 0.0 3.7e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX47171.1 - 3.5e-11 43.4 0.2 7e-11 42.5 0.2 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Rrn6 PF10214.9 ORX47171.1 - 0.22 10.0 6.2 0.33 9.4 6.2 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor FAM176 PF14851.6 ORX47172.1 - 0.15 11.7 0.2 0.31 10.7 0.2 1.4 1 0 0 1 1 1 0 FAM176 family PBP1_TM PF14812.6 ORX47172.1 - 0.22 11.9 5.7 1.2 9.5 5.4 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PIEZO PF15917.5 ORX47172.1 - 0.31 10.5 0.7 0.68 9.4 0.1 1.7 2 0 0 2 2 2 0 Piezo Cwf_Cwc_15 PF04889.12 ORX47172.1 - 1.1 9.0 6.1 2 8.1 6.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ORX47172.1 - 5.2 6.3 5.7 9.1 5.5 5.7 1.3 1 0 0 1 1 1 0 NOA36 protein FYRN PF05964.14 ORX47173.1 - 1.8e-18 66.1 0.0 3.1e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 ORX47173.1 - 9.1e-17 61.0 0.0 1.6e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 F/Y rich C-terminus tRNA_U5-meth_tr PF05958.11 ORX47174.1 - 5e-14 52.1 1.4 1.1e-12 47.7 0.1 3.4 3 2 1 4 4 4 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ORX47174.1 - 4.3e-10 39.6 2.8 5.4e-10 39.3 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX47174.1 - 6.1e-09 36.5 0.0 1.8e-08 35.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX47174.1 - 7.3e-08 32.1 0.1 1.5e-07 31.1 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Cons_hypoth95 PF03602.15 ORX47174.1 - 4.3e-07 29.8 0.0 1.1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 ORX47174.1 - 1.8e-06 27.6 0.0 6.5e-06 25.8 0.0 1.9 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 ORX47174.1 - 4.4e-06 26.3 0.3 4.4e-06 26.3 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ORX47174.1 - 0.00041 20.9 0.0 0.0021 18.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX47174.1 - 0.00074 19.0 0.4 0.003 17.0 0.1 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 ORX47174.1 - 0.0009 19.9 0.7 0.0019 18.9 0.0 2.0 2 1 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX47174.1 - 0.0011 18.3 0.2 0.0036 16.7 0.1 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 ORX47174.1 - 0.0021 18.0 0.5 0.0076 16.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 ORX47174.1 - 0.0025 17.8 0.3 0.029 14.3 0.2 2.2 2 0 0 2 2 2 1 Methyltransferase domain Pox_MCEL PF03291.16 ORX47174.1 - 0.0058 15.8 1.3 0.41 9.7 0.0 2.3 2 1 0 2 2 2 1 mRNA capping enzyme Methyltransf_23 PF13489.6 ORX47174.1 - 0.0066 16.3 0.0 0.02 14.7 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain SPOR PF05036.13 ORX47174.1 - 0.0099 16.2 0.0 0.025 14.9 0.0 1.7 1 0 0 1 1 1 1 Sporulation related domain RRM_1 PF00076.22 ORX47174.1 - 0.018 14.9 0.1 0.05 13.4 0.0 1.9 2 0 0 2 2 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Met_10 PF02475.16 ORX47174.1 - 0.025 14.3 0.0 0.06 13.1 0.0 1.6 1 0 0 1 1 1 0 Met-10+ like-protein PCMT PF01135.19 ORX47174.1 - 0.028 14.2 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) AviRa PF11599.8 ORX47174.1 - 0.035 13.6 1.5 0.046 13.2 0.1 1.8 2 0 0 2 2 2 0 RRNA methyltransferase AviRa TPMT PF05724.11 ORX47174.1 - 0.042 13.5 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NodS PF05401.11 ORX47174.1 - 0.084 12.5 0.1 0.26 10.9 0.1 1.7 2 0 0 2 2 2 0 Nodulation protein S (NodS) RRM_3 PF08777.11 ORX47174.1 - 0.16 12.1 2.3 0.5 10.5 0.7 2.3 2 0 0 2 2 2 0 RNA binding motif UPF0020 PF01170.18 ORX47174.1 - 0.67 9.6 5.4 5.9 6.5 3.9 2.6 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 TMF_TATA_bd PF12325.8 ORX47175.1 - 0.014 15.6 3.4 0.046 13.9 0.1 2.6 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF3375 PF11855.8 ORX47175.1 - 0.035 13.0 0.0 0.063 12.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3375) YabA PF06156.13 ORX47175.1 - 0.047 14.3 7.9 0.083 13.5 1.5 2.6 1 1 1 2 2 2 0 Initiation control protein YabA baeRF_family5 PF18846.1 ORX47175.1 - 0.18 12.0 2.8 0.15 12.3 1.0 1.8 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 Mto2_bdg PF12808.7 ORX47175.1 - 0.65 10.3 3.9 0.65 10.3 1.1 2.5 3 1 0 3 3 3 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF1664 PF07889.12 ORX47175.1 - 1.1 9.3 6.3 6.6 6.8 0.4 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) HOOK PF05622.12 ORX47176.1 - 1.2e-06 27.0 14.9 1.4e-06 26.8 14.9 1.1 1 0 0 1 1 1 1 HOOK protein MAD PF05557.13 ORX47176.1 - 1.3e-06 27.2 16.3 1.5e-06 26.9 16.3 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein HMMR_N PF15905.5 ORX47176.1 - 0.00025 20.6 16.9 0.0029 17.1 1.4 2.0 1 1 1 2 2 2 2 Hyaluronan mediated motility receptor N-terminal TMF_TATA_bd PF12325.8 ORX47176.1 - 0.00033 20.9 15.9 0.091 13.0 10.4 2.3 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding Cep57_MT_bd PF06657.13 ORX47176.1 - 0.0011 19.4 14.3 0.048 14.1 0.1 4.0 2 1 1 4 4 4 1 Centrosome microtubule-binding domain of Cep57 RasGAP_C PF03836.15 ORX47176.1 - 0.0019 18.3 1.2 0.0019 18.3 1.2 2.3 1 1 1 2 2 2 1 RasGAP C-terminus Seryl_tRNA_N PF02403.22 ORX47176.1 - 0.0031 17.7 12.3 0.59 10.4 9.8 2.9 2 1 1 3 3 3 1 Seryl-tRNA synthetase N-terminal domain HAP1_N PF04849.13 ORX47176.1 - 0.0038 16.5 17.5 0.0086 15.3 4.1 2.1 1 1 1 2 2 2 1 HAP1 N-terminal conserved region YabA PF06156.13 ORX47176.1 - 0.0041 17.7 14.4 0.87 10.3 0.4 3.2 1 1 2 3 3 3 2 Initiation control protein YabA Fez1 PF06818.15 ORX47176.1 - 0.0041 17.6 16.8 0.54 10.7 0.3 2.1 1 1 1 2 2 2 2 Fez1 DUF4200 PF13863.6 ORX47176.1 - 0.0041 17.5 18.0 0.9 9.9 14.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4200) ADIP PF11559.8 ORX47176.1 - 0.0049 17.0 3.2 0.0049 17.0 3.2 3.1 2 1 1 3 3 3 1 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 ORX47176.1 - 0.0066 16.6 18.8 0.0083 16.2 1.6 2.1 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ORX47176.1 - 0.0083 15.0 18.5 0.077 11.9 1.2 2.1 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF3450 PF11932.8 ORX47176.1 - 0.01 15.2 13.8 0.35 10.1 10.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Syntaxin-6_N PF09177.11 ORX47176.1 - 0.015 15.9 6.8 0.086 13.4 0.3 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DivIC PF04977.15 ORX47176.1 - 0.023 14.5 19.8 0.14 11.9 0.6 3.7 1 1 1 3 3 3 0 Septum formation initiator APG6_N PF17675.1 ORX47176.1 - 0.029 14.9 22.8 0.21 12.1 0.4 3.1 1 1 1 3 3 3 0 Apg6 coiled-coil region Fib_alpha PF08702.10 ORX47176.1 - 0.036 14.3 11.1 0.92 9.7 5.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 ORX47176.1 - 0.036 14.5 6.3 2 8.9 0.0 3.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 ORX47176.1 - 0.058 13.7 3.6 0.22 11.8 1.5 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) YscO PF07321.12 ORX47176.1 - 0.064 13.2 16.9 0.3 11.0 0.1 2.9 2 1 1 3 3 3 0 Type III secretion protein YscO Kre28 PF17097.5 ORX47176.1 - 0.066 12.2 13.3 0.91 8.4 0.1 2.1 1 1 1 2 2 2 0 Spindle pole body component bZIP_1 PF00170.21 ORX47176.1 - 0.075 13.1 12.6 0.83 9.8 0.1 4.1 3 1 0 3 3 3 0 bZIP transcription factor LRRFIP PF09738.9 ORX47176.1 - 0.088 12.3 18.0 0.13 11.7 2.6 3.0 1 1 1 3 3 3 0 LRRFIP family COG2 PF06148.11 ORX47176.1 - 0.14 12.2 14.2 3.9 7.6 0.1 3.7 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Yuri_gagarin PF15934.5 ORX47176.1 - 0.15 11.9 13.6 4.6 7.0 8.7 2.6 1 1 1 2 2 2 0 Yuri gagarin DUF2746 PF10874.8 ORX47176.1 - 0.16 12.4 0.9 2.4 8.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) CENP-F_leu_zip PF10473.9 ORX47176.1 - 0.18 11.8 18.7 2.9 7.9 12.1 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.9 ORX47176.1 - 0.19 12.0 12.7 0.32 11.3 8.0 2.4 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 THOC7 PF05615.13 ORX47176.1 - 0.23 11.7 15.3 0.4 11.0 0.1 2.8 2 1 0 2 2 2 0 Tho complex subunit 7 USP8_interact PF08941.10 ORX47176.1 - 0.25 11.1 6.8 1.5 8.6 3.9 2.2 2 0 0 2 2 2 0 USP8 interacting GAS PF13851.6 ORX47176.1 - 0.31 10.4 19.9 0.28 10.5 3.5 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 ORX47176.1 - 0.36 11.0 17.3 1.4 9.1 17.4 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 ORX47176.1 - 0.39 11.2 6.9 4.3 7.9 4.1 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Sec20 PF03908.13 ORX47176.1 - 0.44 10.5 3.4 1.2 9.2 1.5 2.3 2 0 0 2 2 2 0 Sec20 Occludin_ELL PF07303.13 ORX47176.1 - 0.44 11.3 11.2 1.5 9.6 4.4 2.9 1 1 2 3 3 3 0 Occludin homology domain LPP PF04728.13 ORX47176.1 - 0.54 10.7 9.8 6.1 7.3 1.4 3.6 3 1 1 4 4 3 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 ORX47176.1 - 0.54 9.6 13.2 2 7.7 13.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HALZ PF02183.18 ORX47176.1 - 0.54 10.5 11.0 2.4 8.5 0.7 4.1 3 1 0 3 3 3 0 Homeobox associated leucine zipper DUF1664 PF07889.12 ORX47176.1 - 0.56 10.3 10.0 4.7 7.3 4.1 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DASH_Dam1 PF08653.10 ORX47176.1 - 0.64 9.9 5.0 15 5.4 0.1 3.7 4 1 0 4 4 2 0 DASH complex subunit Dam1 CENP-O PF09496.10 ORX47176.1 - 0.64 10.0 6.1 0.25 11.3 3.5 1.7 2 0 0 2 2 1 0 Cenp-O kinetochore centromere component FTA4 PF13093.6 ORX47176.1 - 0.65 9.8 11.2 2.2 8.1 11.2 1.9 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 SlyX PF04102.12 ORX47176.1 - 0.7 10.5 13.1 41 4.9 0.1 3.5 2 1 0 2 2 2 0 SlyX DUF2203 PF09969.9 ORX47176.1 - 0.73 10.6 10.7 1.4 9.7 4.4 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) CENP-H PF05837.12 ORX47176.1 - 0.73 10.3 16.1 16 5.9 0.1 3.1 2 1 0 2 2 2 0 Centromere protein H (CENP-H) APC_N_CC PF16689.5 ORX47176.1 - 0.96 9.6 9.3 1.9 8.6 2.8 3.2 2 2 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain GIT_CC PF16559.5 ORX47176.1 - 1.1 9.2 11.7 1.6 8.7 0.2 4.3 3 1 2 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor Exonuc_VII_L PF02601.15 ORX47176.1 - 1.2 8.6 11.1 1.7 8.1 11.1 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 ORX47176.1 - 1.6 7.2 3.3 2.5 6.5 3.3 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family YtxH PF12732.7 ORX47176.1 - 1.7 9.2 6.5 5.5 7.6 4.6 2.4 2 1 0 2 2 2 0 YtxH-like protein Cauli_AT PF03233.13 ORX47176.1 - 2 8.4 8.0 2.1 8.3 3.7 2.2 1 1 1 3 3 3 0 Aphid transmission protein DUF724 PF05266.14 ORX47176.1 - 2.2 8.1 12.6 6.8 6.5 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4446 PF14584.6 ORX47176.1 - 4 7.4 10.0 2.8 7.9 4.4 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) TolA_bind_tri PF16331.5 ORX47176.1 - 4.8 7.3 17.1 1.2 9.3 0.8 3.8 2 2 1 3 3 3 0 TolA binding protein trimerisation DUF4140 PF13600.6 ORX47176.1 - 6.3 7.3 13.6 5.5 7.5 0.2 3.4 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) LMBR1 PF04791.16 ORX47176.1 - 6.6 5.5 7.5 9.2 5.0 7.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TMPIT PF07851.13 ORX47176.1 - 8 5.6 13.7 8.5 5.5 7.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein ZapB PF06005.12 ORX47176.1 - 8.6 6.9 23.2 4.9e+02 1.3 12.7 3.4 1 1 1 2 2 2 0 Cell division protein ZapB FapA PF03961.13 ORX47176.1 - 9.8 4.7 12.7 4.1 5.9 0.6 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A GDC-P PF02347.16 ORX47177.1 - 2.5e-197 656.0 2.6 1.1e-187 624.1 0.3 2.7 3 1 0 3 3 3 2 Glycine cleavage system P-protein Beta_elim_lyase PF01212.21 ORX47177.1 - 0.0068 15.7 2.6 0.074 12.3 0.1 2.8 3 0 0 3 3 3 1 Beta-eliminating lyase DUF1805 PF08827.11 ORX47177.1 - 0.019 15.3 0.0 0.073 13.4 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) SnoaL_4 PF13577.6 ORX47177.1 - 0.053 13.7 0.0 0.23 11.6 0.0 2.1 2 0 0 2 2 2 0 SnoaL-like domain NatB_MDM20 PF09797.9 ORX47178.1 - 1e-94 317.6 4.4 1e-94 317.6 4.4 2.1 1 1 1 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_19 PF14559.6 ORX47178.1 - 6.6e-07 29.7 13.3 0.00047 20.6 0.5 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX47178.1 - 0.0049 17.6 10.7 13 6.9 0.0 7.2 5 2 3 8 8 8 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX47178.1 - 0.067 13.3 0.1 0.68 10.1 0.0 2.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ORX47178.1 - 0.32 11.3 6.1 11 6.4 0.1 3.9 4 1 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr PF14863.6 ORX47178.1 - 0.81 10.1 3.8 0.7 10.3 0.1 2.7 3 0 0 3 3 3 0 Alkyl sulfatase dimerisation Melibiase_C PF17801.1 ORX47179.1 - 0.16 12.0 1.7 9.9 6.3 0.1 2.7 3 0 0 3 3 3 0 Alpha galactosidase C-terminal beta sandwich domain CARDB PF07705.11 ORX47179.1 - 0.82 10.0 4.3 0.55 10.5 1.3 2.2 2 1 0 2 2 2 0 CARDB CHCH PF06747.13 ORX47180.1 - 0.0016 18.5 0.1 0.0024 18.0 0.1 1.3 1 0 0 1 1 1 1 CHCH domain DB PF01682.19 ORX47180.1 - 0.026 14.8 0.6 0.029 14.7 0.6 1.1 1 0 0 1 1 1 0 DB module CNH PF00780.22 ORX47181.1 - 2.5e-42 145.4 0.0 4.6e-42 144.5 0.0 1.4 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX47181.1 - 1.9e-36 126.0 1.1 3e-36 125.3 1.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX47181.1 - 8.6e-16 58.3 0.0 8.1e-15 55.1 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX47181.1 - 0.032 14.7 0.0 0.077 13.5 0.0 1.7 1 0 0 1 1 1 0 PH domain PH_16 PF17838.1 ORX47181.1 - 0.096 12.5 0.0 3.9 7.3 0.0 2.5 2 0 0 2 2 2 0 PH domain FAD_binding_3 PF01494.19 ORX47182.1 - 5.7e-13 48.8 0.0 2.1e-12 47.0 0.0 1.8 1 1 0 1 1 1 1 FAD binding domain SE PF08491.10 ORX47182.1 - 0.00063 18.9 0.0 0.036 13.1 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase OSR1_C PF12202.8 ORX47186.1 - 0.038 14.2 0.1 0.11 12.7 0.1 1.9 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Methyltransf_23 PF13489.6 ORX47187.1 - 2e-17 63.5 0.2 3.2e-17 62.9 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX47187.1 - 4.5e-06 27.3 0.1 9.1e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX47187.1 - 0.00056 20.6 0.2 0.0017 19.0 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX47187.1 - 0.0038 17.8 0.2 0.011 16.3 0.2 1.8 1 1 0 1 1 1 1 Methyltransferase domain Pox_MCEL PF03291.16 ORX47187.1 - 0.012 14.7 0.2 0.017 14.2 0.2 1.1 1 0 0 1 1 1 0 mRNA capping enzyme Ribosomal_L9_N PF01281.19 ORX47187.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L9, N-terminal domain Homeodomain PF00046.29 ORX47188.1 - 7e-16 57.8 0.3 1e-15 57.3 0.3 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX47188.1 - 0.019 14.8 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 Homeobox KN domain Pkinase PF00069.25 ORX47189.1 - 3.5e-12 46.2 0.0 5.2e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47189.1 - 0.00029 20.2 0.0 0.00044 19.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX47189.1 - 0.035 13.4 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like DRE2_N PF16803.5 ORX47190.1 - 0.14 12.4 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus G_path_suppress PF15991.5 ORX47191.1 - 0.00099 19.3 6.7 0.00099 19.3 6.7 2.5 2 1 0 2 2 2 1 G-protein pathway suppressor Nnf1 PF03980.14 ORX47191.1 - 0.038 14.4 2.4 0.038 14.4 0.4 1.8 1 1 1 2 2 2 0 Nnf1 DotU PF09850.9 ORX47191.1 - 0.1 12.3 1.4 0.71 9.6 0.2 2.1 2 0 0 2 2 2 0 Type VI secretion system protein DotU SlyX PF04102.12 ORX47191.1 - 0.15 12.7 3.8 2.4 8.9 0.8 2.4 2 0 0 2 2 2 0 SlyX bZIP_2 PF07716.15 ORX47191.1 - 1.1 9.4 11.6 1.3 9.1 2.6 2.3 2 0 0 2 2 2 0 Basic region leucine zipper APG6_N PF17675.1 ORX47191.1 - 2.2 8.8 8.2 4.6 7.8 8.2 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3385 PF11865.8 ORX47193.1 - 0.0058 16.6 0.1 0.39 10.6 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 ORX47193.1 - 0.013 16.0 0.1 2.4 8.7 0.0 2.5 2 0 0 2 2 2 0 HEAT-like repeat RNA_pol_Rpb5_C PF01191.19 ORX47193.1 - 0.058 13.3 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Lipase_GDSL PF00657.22 ORX47194.1 - 8.7e-09 35.6 0.1 1.4e-08 34.9 0.1 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX47194.1 - 0.00016 22.1 1.5 0.00022 21.7 1.5 1.4 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family HAD_2 PF13419.6 ORX47195.1 - 1.5e-05 25.2 0.0 2.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX47195.1 - 0.072 13.4 0.0 0.092 13.0 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase RNase_T PF00929.24 ORX47196.1 - 1.2e-10 42.2 0.0 1.3e-10 42.0 0.0 1.0 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ORX47196.1 - 0.14 12.1 0.0 0.19 11.7 0.0 1.4 1 1 0 1 1 1 0 3' exoribonuclease, RNase T-like AA_permease_2 PF13520.6 ORX47197.1 - 3.6e-68 230.4 33.5 4.3e-68 230.1 33.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX47197.1 - 1.6e-32 112.8 29.1 2.2e-32 112.3 29.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1516 PF07457.11 ORX47197.1 - 0.35 11.1 5.6 4.2 7.6 0.5 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1516) Ank_2 PF12796.7 ORX47198.1 - 2.4e-21 76.1 1.1 1.4e-13 51.2 0.4 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX47198.1 - 1.6e-15 57.0 6.4 8.9e-06 25.9 0.0 5.0 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX47198.1 - 1.2e-13 51.2 4.0 0.00013 22.5 0.2 4.3 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX47198.1 - 4.9e-12 44.9 3.7 0.023 15.2 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 ORX47198.1 - 5.6e-11 42.4 7.2 0.0019 18.6 0.0 5.1 5 0 0 5 5 5 3 Ankyrin repeat DUF773 PF05600.12 ORX47198.1 - 0.24 10.1 0.9 0.38 9.4 0.9 1.2 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Prefoldin_2 PF01920.20 ORX47199.1 - 2.6e-17 62.7 4.6 3.1e-17 62.5 4.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit ATP-synt_E PF05680.12 ORX47199.1 - 0.07 13.5 3.5 4.4 7.7 0.4 2.1 2 0 0 2 2 2 0 ATP synthase E chain DUF4686 PF15742.5 ORX47199.1 - 0.13 11.3 7.6 0.85 8.7 7.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) T6PP_N PF18572.1 ORX47199.1 - 0.13 12.1 1.6 0.23 11.3 1.6 1.5 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain sCache_2 PF17200.4 ORX47199.1 - 0.32 10.8 3.9 4.4 7.1 0.1 2.1 2 0 0 2 2 2 0 Single Cache domain 2 DivIC PF04977.15 ORX47199.1 - 0.52 10.1 7.0 0.19 11.5 1.6 2.1 2 0 0 2 2 2 0 Septum formation initiator Phage_GP20 PF06810.11 ORX47199.1 - 0.66 9.8 8.1 14 5.5 7.1 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF4140 PF13600.6 ORX47199.1 - 9 6.8 8.4 22 5.5 0.3 2.1 1 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) zf-AN1 PF01428.16 ORX47200.1 - 1.5e-20 73.1 30.5 2.7e-11 43.5 9.3 2.9 3 0 0 3 3 3 2 AN1-like Zinc finger Transp_Tc5_C PF04236.15 ORX47200.1 - 0.0051 17.1 9.4 0.0051 17.1 9.4 2.4 2 0 0 2 2 2 2 Tc5 transposase C-terminal domain DNA_ligase_ZBD PF03119.16 ORX47200.1 - 6.4 6.9 8.5 14 5.8 0.4 2.9 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain SUFU PF05076.13 ORX47201.1 - 0.22 11.5 0.0 0.41 10.6 0.0 1.4 1 0 0 1 1 1 0 Suppressor of fused protein (SUFU) DUF4175 PF13779.6 ORX47203.1 - 0.024 12.6 0.1 0.024 12.6 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) EzrA PF06160.12 ORX47203.1 - 0.11 10.7 0.4 0.17 10.0 0.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Metallophos PF00149.28 ORX47204.1 - 2.1e-33 116.6 0.4 2.7e-33 116.2 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RRM_9 PF18444.1 ORX47205.1 - 2.6e-10 40.0 0.0 4.9e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif LRR_9 PF14580.6 ORX47205.1 - 0.0042 16.6 0.0 0.008 15.7 0.0 1.4 1 0 0 1 1 1 1 Leucine-rich repeat AAA_5 PF07728.14 ORX47205.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PHD PF00628.29 ORX47206.1 - 8.6e-09 35.2 7.3 1.7e-08 34.2 7.3 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX47206.1 - 1.4 8.6 9.7 0.13 11.8 3.9 2.3 2 1 0 2 2 2 0 PHD-finger PQ-loop PF04193.14 ORX47207.1 - 8.4e-27 92.7 7.8 4.4e-17 61.6 1.0 2.7 2 0 0 2 2 2 2 PQ loop repeat Pyridoxal_deC PF00282.19 ORX47208.1 - 6.9e-77 258.7 0.0 1.1e-76 258.1 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain MFS_1 PF07690.16 ORX47209.1 - 1.1e-12 47.5 7.0 1.1e-12 47.5 7.0 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3325 PF11804.8 ORX47209.1 - 0.026 14.6 1.9 1.6 8.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3325) PTR2 PF00854.21 ORX47209.1 - 0.041 12.7 1.1 0.081 11.7 1.0 1.6 2 0 0 2 2 2 0 POT family Tom6 PF17112.5 ORX47209.1 - 0.1 12.1 0.4 0.25 10.9 0.4 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom6, fungal DUF3808 PF10300.9 ORX47210.1 - 2.8e-59 201.1 1.3 5.5e-59 200.2 1.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_16 PF13432.6 ORX47210.1 - 0.00039 21.0 0.8 0.045 14.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX47210.1 - 0.0011 18.9 8.6 2.9 8.2 0.3 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX47210.1 - 0.02 15.4 1.4 0.11 13.0 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX47210.1 - 0.2 12.3 4.2 1.2e+02 3.7 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat ABC2_membrane PF01061.24 ORX47211.1 - 2.6e-79 265.5 66.2 6e-45 153.2 24.5 3.5 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 ORX47211.1 - 1.5e-32 113.0 0.1 1.9e-18 67.3 0.0 2.7 3 0 0 3 3 2 2 ABC transporter PDR_CDR PF06422.12 ORX47211.1 - 1.5e-29 101.7 6.9 1.6e-21 76.0 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 ORX47211.1 - 7.5e-08 32.9 0.0 1.6e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 ORX47211.1 - 1.4e-05 24.4 47.2 0.0039 16.3 23.5 2.8 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 ORX47211.1 - 1.5e-05 25.0 0.1 0.048 13.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX47211.1 - 2.3e-05 24.8 0.0 0.0094 16.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX47211.1 - 0.00012 22.1 0.1 0.004 17.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 ORX47211.1 - 0.0021 17.7 0.1 0.0052 16.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX47211.1 - 0.0029 17.3 0.4 0.019 14.7 0.1 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ORX47211.1 - 0.033 13.9 0.3 2.7 7.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX47211.1 - 0.038 14.5 0.0 0.75 10.4 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX47211.1 - 0.043 13.1 0.0 0.95 8.7 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.19 ORX47211.1 - 0.059 13.0 0.5 1.3 8.6 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ORX47211.1 - 0.06 13.6 0.2 1.6 9.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ORX47211.1 - 0.077 13.4 0.1 30 5.0 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ORX47211.1 - 0.11 12.7 1.1 0.95 9.6 0.1 3.0 3 1 0 3 3 3 0 AAA domain AAA_23 PF13476.6 ORX47211.1 - 0.18 12.2 0.0 0.46 11.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC2_membrane PF01061.24 ORX47212.1 - 9.9e-84 280.0 58.4 1.2e-47 162.1 20.8 3.4 4 0 0 4 4 3 2 ABC-2 type transporter ABC_tran PF00005.27 ORX47212.1 - 5.8e-37 127.3 0.0 2e-19 70.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 ORX47212.1 - 4.6e-30 103.4 4.0 4e-25 87.5 0.1 3.4 4 0 0 4 4 2 2 CDR ABC transporter ABC_trans_N PF14510.6 ORX47212.1 - 1.4e-11 44.8 0.0 3.1e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 ORX47212.1 - 7.5e-06 26.4 0.0 0.02 15.2 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ORX47212.1 - 3e-05 24.0 0.0 0.11 12.3 0.0 2.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ORX47212.1 - 0.00011 22.8 0.1 0.043 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX47212.1 - 0.00011 22.1 0.1 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ORX47212.1 - 0.00013 21.6 0.8 0.021 14.6 0.1 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX47212.1 - 0.00048 20.4 0.0 0.75 10.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain cobW PF02492.19 ORX47212.1 - 0.00061 19.4 0.3 0.87 9.1 0.1 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane_3 PF12698.7 ORX47212.1 - 0.00096 18.4 61.7 0.0025 17.0 23.8 3.7 2 2 1 3 3 3 2 ABC-2 family transporter protein AAA_25 PF13481.6 ORX47212.1 - 0.0034 17.0 0.0 0.03 13.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX47212.1 - 0.0047 17.1 0.6 0.92 9.7 0.1 3.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX47212.1 - 0.0078 15.9 0.8 2.3 7.9 0.2 2.4 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ORX47212.1 - 0.02 14.8 0.6 2.7 7.9 0.2 2.5 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 ORX47212.1 - 0.025 14.8 1.3 0.79 10.0 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ORX47212.1 - 0.061 13.8 0.6 23 5.4 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX47212.1 - 0.097 12.8 0.2 13 5.9 0.1 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ORX47212.1 - 0.15 12.5 0.1 0.56 10.7 0.0 1.9 2 0 0 2 2 1 0 AAA domain PduV-EutP PF10662.9 ORX47212.1 - 0.16 11.7 1.2 5.7 6.7 0.2 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Nipped-B_C PF12830.7 ORX47214.1 - 1.5e-47 162.0 0.2 7.4e-46 156.5 0.0 2.9 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 ORX47214.1 - 9.2e-09 35.4 0.4 1e-05 25.7 0.1 2.9 2 0 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 ORX47214.1 - 3.2e-05 24.0 3.4 0.16 12.0 0.3 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX47214.1 - 0.01 16.3 0.1 5.5 7.6 0.0 4.4 3 1 1 4 4 4 0 HEAT-like repeat RasGEF_N_2 PF14663.6 ORX47214.1 - 0.017 15.5 2.2 12 6.4 0.0 3.8 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT PF02985.22 ORX47214.1 - 0.073 13.4 5.4 12 6.5 0.1 6.0 7 0 0 7 7 7 0 HEAT repeat AbiJ_NTD3 PF18860.1 ORX47214.1 - 0.13 11.8 0.2 5.1 6.6 0.0 2.6 2 0 0 2 2 2 0 AbiJ N-terminal domain 3 Adaptin_N PF01602.20 ORX47214.1 - 0.17 10.4 8.5 0.37 9.3 5.2 3.0 2 1 0 2 2 2 0 Adaptin N terminal region Aa_trans PF01490.18 ORX47218.1 - 1.6e-79 267.6 36.8 1.8e-79 267.4 36.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Peptidase_M24 PF00557.24 ORX47219.1 - 4.2e-51 173.6 0.0 4.9e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Acetyltransf_1 PF00583.25 ORX47221.1 - 1.2e-10 41.6 0.0 1.7e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX47221.1 - 1.1e-07 31.8 0.0 2.2e-07 30.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX47221.1 - 1.5e-07 31.7 0.1 7.2e-07 29.6 0.0 2.0 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX47221.1 - 2.4e-05 24.2 0.0 4.6e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ORX47221.1 - 0.00068 19.7 0.1 0.0015 18.6 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX47221.1 - 0.011 15.9 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 ORX47222.1 - 1.5e-48 165.5 0.0 2.5e-48 164.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47222.1 - 2e-21 76.4 0.0 3.2e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX47222.1 - 0.00022 21.2 0.0 0.0006 19.8 0.0 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIC1 PF07064.13 ORX47222.1 - 0.061 12.7 0.4 0.15 11.4 0.4 1.6 1 0 0 1 1 1 0 RIC1 RIO1 PF01163.22 ORX47222.1 - 0.082 12.5 0.1 0.18 11.4 0.1 1.5 1 1 0 1 1 1 0 RIO1 family RSN1_7TM PF02714.15 ORX47223.1 - 1.1e-77 261.0 33.3 2.5e-77 259.9 33.3 1.6 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX47223.1 - 8.5e-40 136.1 3.4 8.5e-40 136.1 3.4 2.6 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX47223.1 - 9.3e-32 110.7 0.0 1.4e-31 110.1 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter MutL_C PF08676.11 ORX47224.1 - 9.4e-27 93.6 0.0 2e-26 92.5 0.0 1.5 1 0 0 1 1 1 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 ORX47224.1 - 6.4e-23 80.7 0.0 1.3e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ORX47224.1 - 7.6e-13 48.5 0.1 1.5e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX47224.1 - 8.9e-05 23.0 0.1 0.00019 21.9 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glycos_transf_2 PF00535.26 ORX47225.1 - 7.6e-21 74.7 0.0 8.9e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ORX47225.1 - 0.00024 21.1 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ORX47225.1 - 0.076 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 POPLD PF08170.12 ORX47226.1 - 2e-29 101.7 0.1 1.1e-28 99.4 0.0 2.2 2 0 0 2 2 2 1 POPLD (NUC188) domain POP1 PF06978.11 ORX47226.1 - 1.7e-21 77.2 12.4 1.4e-11 44.8 6.4 2.5 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 GCV_T PF01571.21 ORX47226.1 - 6.8e-05 22.4 0.0 0.01 15.2 0.0 2.7 3 0 0 3 3 3 2 Aminomethyltransferase folate-binding domain Clat_adaptor_s PF01217.20 ORX47227.1 - 8.4e-22 77.6 0.5 6.1e-16 58.6 0.2 2.1 2 0 0 2 2 2 2 Clathrin adaptor complex small chain DUF3336 PF11815.8 ORX47228.1 - 2e-41 141.0 3.4 3.7e-41 140.1 3.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 ORX47228.1 - 5.8e-18 65.8 0.0 1.3e-17 64.7 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase CNH PF00780.22 ORX47229.1 - 2.3e-40 138.9 0.1 3.8e-40 138.2 0.1 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX47229.1 - 5.9e-30 104.9 0.1 1.1e-29 104.0 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX47229.1 - 2e-16 60.4 0.0 2.4e-10 40.6 0.0 2.9 1 1 1 2 2 2 2 Pleckstrin homology domain PH_13 PF16652.5 ORX47229.1 - 4.6e-07 29.8 0.0 1.1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ORX47229.1 - 0.00031 20.7 0.0 0.0007 19.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 ORX47229.1 - 0.00043 20.7 0.1 0.0052 17.3 0.0 3.0 4 0 0 4 4 4 1 PH domain PH_16 PF17838.1 ORX47229.1 - 0.0087 15.9 0.0 0.024 14.5 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_6 PF15406.6 ORX47229.1 - 0.13 12.5 0.0 0.37 11.1 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain WD40 PF00400.32 ORX47233.1 - 1.9e-21 76.0 16.0 5.7e-06 27.0 0.3 7.7 7 2 0 7 7 7 4 WD domain, G-beta repeat F-box-like PF12937.7 ORX47233.1 - 5.3e-13 48.6 0.7 1.8e-12 46.9 0.7 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX47233.1 - 6.7e-08 32.2 0.3 1.9e-07 30.8 0.3 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ORX47233.1 - 1.5e-07 30.4 3.6 0.0017 17.1 0.2 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 F-box_4 PF15966.5 ORX47233.1 - 0.013 15.4 0.1 0.045 13.6 0.1 2.0 2 0 0 2 2 2 0 F-box PALB2_WD40 PF16756.5 ORX47233.1 - 0.068 12.1 0.5 56 2.5 0.0 3.7 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Na_H_Exchanger PF00999.21 ORX47234.1 - 6.7e-52 176.6 17.9 1.1e-51 175.9 17.9 1.3 1 1 0 1 1 1 1 Sodium/hydrogen exchanger family DUF3021 PF11457.8 ORX47234.1 - 0.028 14.7 1.7 0.028 14.7 1.7 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3021) Phage_holin_3_3 PF16083.5 ORX47234.1 - 3.4 7.8 9.0 2.4 8.3 0.3 3.8 4 0 0 4 4 4 0 LydA holin phage, holin superfamily III CPP1-like PF11833.8 ORX47234.1 - 4.5 6.9 7.6 12 5.4 0.0 3.1 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like YrhC PF14143.6 ORX47234.1 - 4.6 7.4 8.6 0.22 11.6 0.2 3.0 3 0 0 3 3 3 0 YrhC-like protein zf-MYND PF01753.18 ORX47235.1 - 0.00013 22.0 25.6 0.00038 20.5 25.6 1.9 1 1 0 1 1 1 1 MYND finger Erf4 PF10256.9 ORX47235.1 - 0.0011 19.0 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family EMP24_GP25L PF01105.24 ORX47236.1 - 2e-48 164.7 0.4 2.5e-48 164.5 0.4 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD F-box PF00646.33 ORX47238.1 - 8.3e-08 31.9 0.5 1.4e-07 31.2 0.5 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX47238.1 - 3.1e-07 30.2 2.5 5.3e-07 29.4 2.5 1.4 1 0 0 1 1 1 1 F-box-like XPA_C PF05181.12 ORX47238.1 - 0.04 13.9 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 XPA protein C-terminus MscS_TM PF12794.7 ORX47238.1 - 0.074 11.9 3.1 3.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Rrn6 PF10214.9 ORX47238.1 - 1.5 7.2 6.8 0.099 11.1 1.8 1.5 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor PAP_assoc PF03828.19 ORX47239.1 - 2.3e-17 62.9 0.0 4.4e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX47239.1 - 3e-08 33.8 0.0 5.1e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ORX47239.1 - 0.011 15.5 0.1 0.054 13.3 0.0 1.9 2 0 0 2 2 2 0 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 ORX47239.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase NDK PF00334.19 ORX47240.1 - 1e-36 125.9 0.0 1.1e-36 125.8 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase FAD_binding_3 PF01494.19 ORX47241.1 - 2.4e-21 76.4 0.0 9e-12 44.9 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ORX47241.1 - 0.00017 21.7 0.0 0.00045 20.4 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ORX47241.1 - 0.00038 19.3 0.1 0.0011 17.8 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 ORX47241.1 - 0.0052 16.4 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Phe_hydrox_dim PF07976.12 ORX47241.1 - 0.0072 16.4 0.0 0.02 14.9 0.0 1.7 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 ORX47241.1 - 0.014 14.6 0.0 0.038 13.2 0.0 1.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX47241.1 - 0.02 14.2 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 ORX47241.1 - 0.038 13.2 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Noc2 PF03715.13 ORX47242.1 - 1.3e-99 333.2 1.3 1.3e-99 333.2 1.3 2.1 2 1 0 2 2 2 1 Noc2p family SET PF00856.28 ORX47243.1 - 3.8e-20 72.9 0.0 5.9e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 SET domain Rubis-subs-bind PF09273.11 ORX47243.1 - 2.8e-08 34.5 0.0 6e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding Cyclin_N PF00134.23 ORX47244.1 - 1.7e-14 53.7 0.1 2.3e-14 53.2 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX47244.1 - 1.9e-10 41.4 0.2 2.3e-10 41.0 0.2 1.1 1 0 0 1 1 1 1 Cyclin Imm3 PF14425.6 ORX47244.1 - 0.093 12.8 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Immunity protein Imm3 Med13_C PF06333.12 ORX47245.1 - 2.2e-59 201.4 3.4 2.2e-59 201.4 3.4 5.2 6 1 1 7 7 7 1 Mediator complex subunit 13 C-terminal domain MID_MedPIWI PF18296.1 ORX47245.1 - 3.8e-21 76.0 0.2 6.9e-13 49.0 0.0 4.4 4 1 1 5 5 5 2 MID domain of medPIWI Solute_trans_a PF03619.16 ORX47246.1 - 1.5e-42 146.0 12.1 1.8e-42 145.7 12.1 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha CD34_antigen PF06365.12 ORX47246.1 - 0.097 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family Abhydrolase_1 PF00561.20 ORX47247.1 - 1.3e-08 34.8 0.0 6.2e-08 32.6 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX47247.1 - 1.6e-07 30.9 0.1 2.4e-07 30.3 0.1 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX47247.1 - 3.3e-05 24.6 0.0 4.9e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 ORX47247.1 - 0.00041 20.0 0.0 0.0012 18.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3089) Palm_thioest PF02089.15 ORX47247.1 - 0.0021 17.9 0.0 0.0032 17.3 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase OTOS PF15182.6 ORX47247.1 - 0.059 13.3 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Otospiralin Chitin_synth_1 PF01644.17 ORX47248.1 - 4.9e-79 264.0 0.0 7.4e-79 263.4 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX47248.1 - 2.4e-30 104.3 0.1 5.1e-30 103.2 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX47248.1 - 3.7e-21 75.3 5.0 3.6e-17 62.2 0.1 2.3 1 1 1 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX47248.1 - 0.00077 19.4 13.3 0.011 15.7 13.3 2.5 1 1 0 1 1 1 1 Glycosyl transferase family group 2 DUF2178 PF09946.9 ORX47248.1 - 0.05 13.8 4.1 0.14 12.4 4.1 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) AA_permease_2 PF13520.6 ORX47249.1 - 9.4e-32 110.4 39.3 9.4e-32 110.4 39.3 1.6 1 1 1 2 2 2 2 Amino acid permease TEX29 PF15839.5 ORX47249.1 - 1.9 9.2 5.2 0.31 11.7 0.6 2.2 2 0 0 2 2 2 0 Testis-expressed sequence 29 protein AA_permease_2 PF13520.6 ORX47250.1 - 5.7e-43 147.3 47.7 7.9e-43 146.8 47.7 1.2 1 0 0 1 1 1 1 Amino acid permease OrfB_Zn_ribbon PF07282.11 ORX47396.1 - 0.0013 18.6 0.2 0.0023 17.8 0.2 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Anti-TRAP PF15777.5 ORX47396.1 - 0.044 13.8 0.0 0.086 12.8 0.0 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein TF_Zn_Ribbon PF08271.12 ORX47396.1 - 0.062 12.8 0.6 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding Lar_restr_allev PF14354.6 ORX47396.1 - 0.081 13.3 0.3 0.22 11.9 0.2 1.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar Thiolase_N PF00108.23 ORX47397.1 - 1.9e-78 263.4 0.1 3.9e-78 262.4 0.0 1.6 2 0 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX47397.1 - 1.2e-48 163.8 1.5 2.7e-48 162.7 0.6 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX47397.1 - 0.0036 16.9 0.2 0.0036 16.9 0.2 2.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Dodecin PF07311.12 ORX47397.1 - 0.092 13.0 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Dodecin KxDL PF10241.9 ORX47398.1 - 0.0011 19.2 2.8 0.0011 19.2 2.8 3.2 3 1 1 4 4 4 1 Uncharacterized conserved protein Ycf54 PF10674.9 ORX47398.1 - 0.071 13.4 1.1 0.24 11.7 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2488) TTL PF03133.15 ORX47399.1 - 7.7e-55 186.1 0.5 1.1e-54 185.6 0.5 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ORX47399.1 - 0.003 16.8 0.0 0.0094 15.2 0.0 1.8 2 0 0 2 2 2 1 YheC/D like ATP-grasp AstB PF04996.12 ORX47399.1 - 0.095 11.4 0.4 0.2 10.3 0.1 1.6 2 0 0 2 2 2 0 Succinylarginine dihydrolase Plasmid_RAQPRD PF09686.10 ORX47399.1 - 0.1 12.8 0.6 8.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) INCENP_ARK-bind PF03941.15 ORX47399.1 - 0.19 11.7 0.3 0.19 11.7 0.3 2.5 2 0 0 2 2 2 0 Inner centromere protein, ARK binding region DUF2695 PF10905.8 ORX47399.1 - 0.48 10.7 2.1 0.66 10.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2695) zf-C2H2 PF00096.26 ORX47401.1 - 0.0063 16.9 2.9 0.28 11.7 0.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type bZIP_2 PF07716.15 ORX47402.1 - 2.9e-13 49.7 9.2 6.1e-13 48.6 9.2 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX47402.1 - 0.0016 18.5 5.6 0.0033 17.5 5.6 1.5 1 0 0 1 1 1 1 bZIP transcription factor XhlA PF10779.9 ORX47402.1 - 0.06 13.6 1.1 0.12 12.6 1.1 1.5 1 0 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.15 ORX47402.1 - 3.8 7.4 7.4 0.25 11.2 1.4 2.0 2 0 0 2 2 2 0 Septum formation initiator Pex2_Pex12 PF04757.14 ORX47403.1 - 2.4e-38 132.0 3.2 3e-38 131.7 3.2 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 ORX47403.1 - 1.1e-08 35.3 13.6 2.3e-08 34.2 13.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX47403.1 - 1.4e-08 34.5 9.6 2.3e-08 33.8 9.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX47403.1 - 5.4e-08 32.6 12.7 1e-07 31.7 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX47403.1 - 3e-07 30.2 10.8 5.3e-07 29.4 10.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ORX47403.1 - 4.6e-07 29.6 13.3 9.8e-07 28.5 13.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX47403.1 - 6.1e-05 22.9 10.2 0.00011 22.0 10.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ORX47403.1 - 9.9e-05 22.6 10.2 0.00024 21.3 10.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX47403.1 - 0.00016 21.7 11.5 0.00037 20.4 11.5 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ORX47403.1 - 0.0019 18.3 11.2 0.0049 17.0 11.2 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 ORX47403.1 - 0.17 12.0 4.6 0.4 10.8 4.6 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 ORX47403.1 - 0.64 9.9 5.1 1.2 9.0 5.1 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ORX47403.1 - 0.99 9.3 9.4 2.5 8.0 9.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 ORX47403.1 - 3.5 7.4 6.5 0.69 9.7 2.6 1.9 2 1 0 2 2 2 0 RING-like zinc finger Ytp1 PF10355.9 ORX47404.1 - 2.3e-104 348.5 9.8 2.3e-104 348.5 9.8 1.4 2 0 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ORX47404.1 - 2e-23 82.2 3.1 2e-23 82.2 3.1 3.5 4 0 0 4 4 4 2 Domain of unknown function (DUF2427) DUF1189 PF06691.11 ORX47404.1 - 0.035 13.7 0.7 1.1 8.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) Cytochrom_B561 PF03188.16 ORX47404.1 - 0.32 11.1 32.9 0.054 13.6 1.7 4.6 5 1 0 5 5 5 0 Eukaryotic cytochrome b561 ABC2_membrane_3 PF12698.7 ORX47404.1 - 5.9 5.9 16.9 0.12 11.4 1.3 3.2 2 1 1 3 3 3 0 ABC-2 family transporter protein zf-HC5HC2H_2 PF13832.6 ORX47405.1 - 9.6e-17 61.1 20.6 8.4e-16 58.1 6.0 3.7 3 0 0 3 3 3 2 PHD-zinc-finger like domain BAH PF01426.18 ORX47405.1 - 1.6e-15 57.0 0.0 3.7e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H PF13771.6 ORX47405.1 - 1.3e-12 47.8 2.0 1.3e-12 47.8 2.0 4.1 3 1 1 4 4 4 1 PHD-like zinc-binding domain PHD PF00628.29 ORX47405.1 - 2.2e-10 40.2 50.5 4.6e-07 29.6 9.5 4.8 6 0 0 6 6 6 3 PHD-finger PHD_2 PF13831.6 ORX47405.1 - 1.8e-08 33.8 3.3 1.8e-08 33.8 3.3 5.1 5 0 0 5 5 5 2 PHD-finger GATA PF00320.27 ORX47405.1 - 0.00014 21.4 7.6 0.00014 21.4 7.6 3.3 2 1 0 2 2 2 1 GATA zinc finger FYVE_2 PF02318.16 ORX47405.1 - 0.002 18.3 3.0 0.002 18.3 3.0 3.5 4 0 0 4 4 4 1 FYVE-type zinc finger Myb_DNA-bind_7 PF15963.5 ORX47405.1 - 0.0061 16.4 0.7 0.016 15.1 0.7 1.7 1 0 0 1 1 1 1 Myb DNA-binding like ELM2 PF01448.24 ORX47405.1 - 0.048 14.4 0.3 0.15 12.8 0.3 1.9 1 1 0 1 1 1 0 ELM2 domain SPX PF03105.19 ORX47405.1 - 1.8 8.4 7.2 0.41 10.5 2.2 2.0 2 0 0 2 2 2 0 SPX domain Pex2_Pex12 PF04757.14 ORX47406.1 - 1.7e-49 168.4 8.8 2e-49 168.2 8.8 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 ORX47406.1 - 4.1e-06 26.6 1.0 6.5e-06 25.9 1.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX47406.1 - 8.7e-05 22.8 1.9 0.00014 22.1 1.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX47406.1 - 9.6e-05 22.1 2.2 0.00018 21.3 2.0 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX47406.1 - 0.0078 16.1 1.9 0.013 15.3 1.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 ORX47406.1 - 0.0079 16.2 1.9 0.013 15.5 1.9 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-C3HC4_4 PF15227.6 ORX47406.1 - 0.013 15.7 5.2 0.025 14.7 5.2 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ORX47406.1 - 0.21 11.6 4.6 0.39 10.8 4.6 1.4 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX47406.1 - 1.5 8.7 4.5 19 5.2 3.7 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 UPF0014 PF03649.13 ORX47409.1 - 1.9e-54 184.6 20.1 2.4e-54 184.3 20.1 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) BPD_transp_1 PF00528.22 ORX47409.1 - 0.004 16.9 13.7 0.004 16.9 13.7 2.3 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component FlxA PF14282.6 ORX47410.1 - 0.23 11.5 12.6 0.34 10.9 1.2 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF4763 PF15960.5 ORX47410.1 - 2.5 7.4 20.9 2.2 7.5 6.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) APG6_N PF17675.1 ORX47410.1 - 3.3 8.2 13.5 1.4 9.5 8.3 2.6 2 1 1 3 3 3 0 Apg6 coiled-coil region ILEI PF15711.5 ORX47411.1 - 0.15 12.6 0.0 0.47 11.0 0.0 1.8 2 0 0 2 2 2 0 Interleukin-like EMT inducer UPF0016 PF01169.19 ORX47412.1 - 0.026 14.8 34.0 0.42 11.0 9.2 3.7 1 1 2 3 3 3 0 Uncharacterized protein family UPF0016 UCH PF00443.29 ORX47413.1 - 1.1e-60 205.3 0.0 2.1e-60 204.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ORX47413.1 - 2.5e-17 63.3 0.0 7e-17 61.8 0.0 1.8 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ORX47413.1 - 4.1e-10 39.8 0.0 0.00077 19.1 0.0 3.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ORX47413.1 - 1.1e-06 28.5 0.0 2.4e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 ORX47414.1 - 3e-52 177.6 0.0 4.2e-52 177.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ORX47414.1 - 1.4e-11 44.8 0.1 3.2e-11 43.7 0.1 1.6 1 0 0 1 1 1 1 DUSP domain UCH_1 PF13423.6 ORX47414.1 - 1.3e-10 41.4 0.1 0.006 16.2 0.0 3.2 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ORX47414.1 - 0.00036 20.3 0.0 0.00079 19.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal HECT PF00632.25 ORX47415.1 - 7.8e-52 176.7 0.0 1.5e-51 175.7 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GCIP PF13324.6 ORX47415.1 - 2.3 7.7 5.4 6.9 6.2 5.4 1.8 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting FBPase PF00316.20 ORX47416.1 - 2.8e-72 242.2 0.2 4.4e-72 241.5 0.1 1.4 2 0 0 2 2 2 1 Fructose-1-6-bisphosphatase, N-terminal domain NdhM PF10664.9 ORX47416.1 - 0.13 12.5 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M DDHD PF02862.17 ORX47417.1 - 2e-24 87.0 0.2 6e-13 49.5 0.1 2.2 2 0 0 2 2 2 2 DDHD domain Zn_clus PF00172.18 ORX47418.1 - 1.1e-07 31.9 10.9 1.7e-07 31.2 10.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ESX-1_EspG PF14011.6 ORX47418.1 - 0.02 14.5 0.2 0.031 13.9 0.2 1.2 1 0 0 1 1 1 0 EspG family Macoilin PF09726.9 ORX47418.1 - 0.31 9.5 8.0 0.46 9.0 8.0 1.2 1 0 0 1 1 1 0 Macoilin family FapA PF03961.13 ORX47418.1 - 0.32 9.5 3.3 0.42 9.2 3.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 ORX47418.1 - 0.34 9.8 4.5 0.43 9.4 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 ORX47418.1 - 0.42 8.5 2.7 0.54 8.1 2.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ORX47418.1 - 2.7 7.3 6.6 3.7 6.8 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ras PF00071.22 ORX47419.1 - 3.9e-57 192.4 0.1 4.7e-57 192.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX47419.1 - 1.2e-36 125.6 0.2 3.5e-36 124.0 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX47419.1 - 1.8e-16 60.1 0.1 2.1e-16 59.9 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX47419.1 - 1.1e-05 25.1 0.1 3.3e-05 23.5 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX47419.1 - 1.9e-05 24.2 0.0 2.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX47419.1 - 0.00015 21.8 0.0 0.00022 21.3 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase NTPase_1 PF03266.15 ORX47419.1 - 0.00072 19.5 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 NTPase RsgA_GTPase PF03193.16 ORX47419.1 - 0.0056 16.6 0.2 2.2 8.2 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_24 PF13479.6 ORX47419.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ORX47419.1 - 0.057 12.7 0.1 0.14 11.4 0.0 1.6 2 0 0 2 2 2 0 Septin G-alpha PF00503.20 ORX47419.1 - 0.11 11.6 0.1 0.56 9.3 0.1 1.9 1 1 1 2 2 2 0 G-protein alpha subunit Pox_A32 PF04665.12 ORX47419.1 - 0.19 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein PBP PF01161.20 ORX47420.1 - 2.7e-18 66.6 0.2 3.3e-18 66.3 0.2 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein GATA PF00320.27 ORX47421.1 - 1.3e-29 101.5 18.3 2.7e-15 55.7 3.9 2.5 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX47421.1 - 1.5e-06 27.6 3.8 0.0033 16.9 0.1 2.3 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX47421.1 - 0.0015 18.6 2.6 0.42 10.8 0.2 2.6 2 0 0 2 2 2 2 Zinc ribbon domain Auto_anti-p27 PF06677.12 ORX47421.1 - 0.0043 17.2 6.1 0.31 11.2 0.5 2.7 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Sec2p PF06428.11 ORX47421.1 - 0.059 13.3 0.4 0.096 12.7 0.4 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p zf-ribbon_3 PF13248.6 ORX47421.1 - 0.11 11.9 9.8 4.7 6.7 0.1 4.3 4 0 0 4 4 4 0 zinc-ribbon domain DZR PF12773.7 ORX47421.1 - 0.46 10.6 15.7 0.19 11.8 8.8 3.2 1 1 1 2 2 2 0 Double zinc ribbon HLH PF00010.26 ORX47422.1 - 3.2e-14 52.6 0.4 3.2e-14 52.6 0.4 2.1 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain TMPIT PF07851.13 ORX47422.1 - 0.55 9.4 1.8 0.76 9.0 1.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein Med9 PF07544.13 ORX47422.1 - 4.2 7.5 9.8 17 5.6 3.0 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 MMM1 PF10296.9 ORX47423.1 - 2.1e-72 244.0 1.0 3.4e-66 223.6 0.0 2.6 1 1 1 2 2 2 2 Maintenance of mitochondrial morphology protein 1 BRO1 PF03097.18 ORX47424.1 - 1.6e-22 79.9 0.2 2.1e-22 79.5 0.2 1.1 1 0 0 1 1 1 1 BRO1-like domain DUF5355 PF17306.2 ORX47424.1 - 0.0011 18.1 1.2 0.046 12.8 1.1 2.3 1 1 1 2 2 2 2 Family of unknown function (DUF5355) OrfB_Zn_ribbon PF07282.11 ORX47426.1 - 0.00025 20.9 0.1 0.00045 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-CSL PF05207.13 ORX47427.1 - 2.8e-24 84.6 1.9 4e-24 84.1 1.9 1.3 1 0 0 1 1 1 1 CSL zinc finger zf-RING_4 PF14570.6 ORX47427.1 - 0.015 15.1 1.1 0.025 14.4 1.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_7 PF02591.15 ORX47427.1 - 0.019 15.1 0.1 0.038 14.2 0.1 1.6 1 0 0 1 1 1 0 C4-type zinc ribbon domain RCC1 PF00415.18 ORX47428.1 - 3e-17 63.0 0.5 3.3e-08 34.0 0.0 2.1 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX47428.1 - 7e-06 25.7 4.6 0.0041 16.9 1.0 3.1 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ORX47429.1 - 5.2e-73 241.5 10.2 8.1e-12 45.6 0.0 7.2 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX47429.1 - 4e-42 141.2 32.6 7.4e-10 38.4 0.3 8.2 8 1 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat Kelch_6 PF13964.6 ORX47429.1 - 0.14 12.5 0.2 38 4.8 0.1 3.5 4 0 0 4 4 4 0 Kelch motif Syja_N PF02383.18 ORX47430.1 - 3.1e-83 279.7 0.0 5.4e-83 279.0 0.0 1.4 1 0 0 1 1 1 1 SacI homology domain hSac2 PF12456.8 ORX47430.1 - 6.5e-31 106.4 0.0 1.5e-30 105.3 0.0 1.6 1 0 0 1 1 1 1 Inositol phosphatase YlbD_coat PF14071.6 ORX47432.1 - 0.076 13.3 2.7 0.2 11.9 1.1 2.6 1 1 0 2 2 2 0 Putative coat protein Lectin_N PF03954.14 ORX47432.1 - 0.1 12.4 11.0 1.3 8.8 1.3 4.3 2 2 2 4 4 4 0 Hepatic lectin, N-terminal domain TolA_bind_tri PF16331.5 ORX47432.1 - 0.1 12.7 15.7 0.32 11.1 1.0 4.5 4 0 0 4 4 4 0 TolA binding protein trimerisation HEPN_Toprim_N PF18871.1 ORX47432.1 - 0.18 11.7 5.3 0.24 11.3 2.6 2.2 2 0 0 2 2 2 0 HEPN/Toprim N-terminal domain 1 Translin PF01997.16 ORX47432.1 - 0.46 10.4 6.7 0.15 12.0 2.8 2.1 2 0 0 2 2 2 0 Translin family Laminin_II PF06009.12 ORX47432.1 - 0.55 10.2 13.2 2.1 8.4 0.1 4.7 3 2 2 5 5 5 0 Laminin Domain II LPP PF04728.13 ORX47432.1 - 0.73 10.3 11.2 17 5.9 0.1 5.4 5 0 0 5 5 5 0 Lipoprotein leucine-zipper Fez1 PF06818.15 ORX47432.1 - 1.6 9.2 20.0 1.7 9.1 5.7 3.6 2 2 0 2 2 2 0 Fez1 DASH_Dad3 PF08656.10 ORX47432.1 - 3.8 7.7 6.0 7.3 6.8 0.0 4.1 3 2 0 3 3 3 0 DASH complex subunit Dad3 FlaC_arch PF05377.11 ORX47432.1 - 3.9 7.9 9.3 13 6.2 0.0 4.9 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) TMF_TATA_bd PF12325.8 ORX47432.1 - 4.1 7.7 23.3 0.27 11.5 0.5 5.1 2 2 2 5 5 5 0 TATA element modulatory factor 1 TATA binding Speriolin_C PF15059.6 ORX47433.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.6 1 1 0 1 1 1 0 Speriolin C-terminus Cnd3 PF12719.7 ORX47435.1 - 0.045 13.0 0.1 0.091 11.9 0.1 1.5 1 0 0 1 1 1 0 Nuclear condensing complex subunits, C-term domain ARA70 PF12489.8 ORX47435.1 - 6 7.1 8.9 0.5 10.6 0.1 3.1 3 0 0 3 3 3 0 Nuclear coactivator DUF3874 PF12990.7 ORX47436.1 - 0.038 14.3 0.0 0.1 12.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknonw function from B. Theta Gene description (DUF3874) OCD_Mu_crystall PF02423.15 ORX47438.1 - 8.5e-51 172.8 1.5 1e-50 172.5 1.5 1.0 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 ORX47438.1 - 9.8e-10 38.6 0.0 2.6e-09 37.3 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GFO_IDH_MocA PF01408.22 ORX47438.1 - 0.0043 17.9 0.0 0.0088 16.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Peptidase_M17_N PF02789.17 ORX47438.1 - 0.027 14.3 0.0 0.072 13.0 0.0 1.7 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain DUF4279 PF14106.6 ORX47438.1 - 0.027 14.7 0.0 0.046 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Sacchrp_dh_NADP PF03435.18 ORX47438.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.7 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ORX47438.1 - 0.047 14.1 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding PPP4R2 PF09184.11 ORX47439.1 - 0.81 9.2 24.2 0.3 10.6 22.1 1.4 2 0 0 2 2 2 0 PPP4R2 MAJIN PF15077.6 ORX47439.1 - 3.6 7.3 9.0 6.4 6.5 9.0 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein Cwf_Cwc_15 PF04889.12 ORX47439.1 - 6.5 6.4 26.2 1.1 8.9 22.5 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Membralin PF09746.9 ORX47439.1 - 7.4 5.5 9.5 11 5.0 9.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein peroxidase PF00141.23 ORX47440.1 - 3.1e-44 151.4 0.0 4.7e-44 150.8 0.0 1.2 1 0 0 1 1 1 1 Peroxidase WD40 PF00400.32 ORX47441.1 - 7.5e-06 26.6 0.5 0.35 11.8 0.0 4.6 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX47441.1 - 0.00047 20.4 0.0 8 6.8 0.0 4.2 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Utp8 PF10395.9 ORX47441.1 - 0.0015 17.1 0.0 0.15 10.5 0.0 2.1 1 1 1 2 2 2 2 Utp8 family CPSF_A PF03178.15 ORX47441.1 - 0.0033 16.8 0.0 0.34 10.2 0.0 2.2 2 0 0 2 2 2 2 CPSF A subunit region WD40_3 PF15911.5 ORX47441.1 - 0.01 15.8 0.0 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Abhydrolase_6 PF12697.7 ORX47442.1 - 2.8e-21 77.1 0.4 3.3e-21 76.9 0.4 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX47442.1 - 1.3e-17 63.9 0.1 2.9e-17 62.7 0.1 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX47442.1 - 1.1e-15 58.0 0.1 1.6e-15 57.5 0.1 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ORX47442.1 - 1.6e-07 30.5 0.1 2.6e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme PGAP1 PF07819.13 ORX47442.1 - 2.6e-05 24.1 0.5 0.0012 18.6 0.2 2.3 1 1 1 2 2 2 1 PGAP1-like protein Abhydrolase_2 PF02230.16 ORX47442.1 - 4.4e-05 23.4 0.0 0.081 12.7 0.1 2.5 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Lipase_3 PF01764.25 ORX47442.1 - 9e-05 22.4 0.1 0.00015 21.7 0.1 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF676 PF05057.14 ORX47442.1 - 0.00018 21.1 0.0 0.00035 20.1 0.0 1.5 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Peptidase_S9 PF00326.21 ORX47442.1 - 0.00071 19.1 0.0 1.1 8.7 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family AXE1 PF05448.12 ORX47442.1 - 0.00086 18.1 0.2 0.0033 16.1 0.1 1.9 1 1 1 2 2 2 1 Acetyl xylan esterase (AXE1) Ser_hydrolase PF06821.13 ORX47442.1 - 0.0013 18.6 0.3 0.0063 16.4 0.1 2.2 2 1 0 2 2 2 1 Serine hydrolase VirJ PF06057.11 ORX47442.1 - 0.002 18.0 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Chlorophyllase PF07224.11 ORX47442.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Thioesterase PF00975.20 ORX47442.1 - 0.016 15.4 0.1 0.025 14.7 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF1749 PF08538.10 ORX47442.1 - 0.045 12.8 0.1 0.12 11.5 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) Lipase_2 PF01674.18 ORX47442.1 - 0.17 11.4 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 2) SH3BGR PF04908.15 ORX47443.1 - 2.1e-13 50.2 3.8 5.3e-13 49.0 0.0 3.3 2 1 0 3 3 3 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 ORX47443.1 - 0.0007 19.8 0.5 0.0026 17.9 0.0 2.3 2 0 0 2 2 2 1 Glutaredoxin PKcGMP_CC PF16808.5 ORX47443.1 - 0.0036 17.1 1.9 0.0036 17.1 1.9 5.6 5 0 0 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF3584 PF12128.8 ORX47443.1 - 6.1 4.2 78.1 4.1 4.8 35.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Sugar_tr PF00083.24 ORX47446.1 - 5.7e-35 121.1 33.1 3.4e-32 111.9 33.1 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX47446.1 - 2.7e-19 69.3 64.2 1.8e-18 66.6 38.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX47446.1 - 0.0031 16.1 3.8 0.0031 16.1 3.8 2.6 2 1 0 2 2 2 1 MFS/sugar transport protein CtnDOT_TraJ PF07863.11 ORX47446.1 - 0.081 13.6 2.5 3.2 8.5 0.0 2.6 2 0 0 2 2 2 0 Homologues of TraJ from Bacteroides conjugative transposon NAD_binding_10 PF13460.6 ORX47447.1 - 4.3e-30 105.0 0.1 5.2e-30 104.7 0.1 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX47447.1 - 0.0001 21.9 0.2 0.00075 19.1 0.2 2.1 1 1 1 2 2 2 1 NmrA-like family TrkA_N PF02254.18 ORX47447.1 - 0.0017 18.6 0.1 0.0047 17.2 0.0 1.8 2 0 0 2 2 2 1 TrkA-N domain Epimerase PF01370.21 ORX47447.1 - 0.002 17.6 0.0 0.0025 17.3 0.0 1.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX47447.1 - 0.022 13.7 0.1 0.028 13.4 0.1 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family UPF0052 PF01933.18 ORX47447.1 - 0.027 13.7 0.0 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0052 CbiC PF02570.15 ORX47447.1 - 0.12 12.1 0.0 0.24 11.0 0.0 1.5 2 0 0 2 2 2 0 Precorrin-8X methylmutase NAD_binding_10 PF13460.6 ORX47448.1 - 2.6e-25 89.4 0.0 2.8e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX47448.1 - 0.0017 17.9 0.0 0.018 14.6 0.0 2.1 2 1 0 2 2 2 1 NmrA-like family UPF0052 PF01933.18 ORX47448.1 - 0.0067 15.7 0.0 0.014 14.7 0.0 1.4 2 0 0 2 2 2 1 Uncharacterised protein family UPF0052 XFP_C PF09363.10 ORX47448.1 - 0.13 11.7 0.1 0.18 11.2 0.1 1.1 1 0 0 1 1 1 0 XFP C-terminal domain Aa_trans PF01490.18 ORX47449.1 - 1.3e-71 241.5 27.1 1.6e-71 241.2 27.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NAD_binding_10 PF13460.6 ORX47450.1 - 3.1e-15 56.6 0.1 4.9e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX47450.1 - 1.4e-11 44.4 0.8 1.1e-10 41.4 0.8 1.9 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ORX47450.1 - 2.8e-05 23.7 0.4 0.00027 20.5 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family PAC2 PF09754.9 ORX47450.1 - 0.00024 21.2 0.0 0.00029 20.9 0.0 1.2 1 0 0 1 1 1 1 PAC2 family adh_short PF00106.25 ORX47450.1 - 0.00027 20.4 0.1 0.0011 18.4 0.0 1.8 1 1 0 1 1 1 1 short chain dehydrogenase GDP_Man_Dehyd PF16363.5 ORX47450.1 - 0.0015 18.0 0.1 0.0061 16.0 0.0 1.8 1 1 1 2 2 2 1 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 ORX47450.1 - 0.0049 17.3 0.2 0.012 16.0 0.2 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 ORX47450.1 - 0.0049 17.1 0.0 0.008 16.4 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain KR PF08659.10 ORX47450.1 - 0.0074 16.2 0.1 0.015 15.2 0.1 1.5 1 1 0 1 1 1 1 KR domain NAD_binding_7 PF13241.6 ORX47450.1 - 0.016 15.6 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 ORX47450.1 - 0.045 13.8 0.0 0.062 13.4 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase 3Beta_HSD PF01073.19 ORX47450.1 - 0.12 11.3 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family ABC_tran PF00005.27 ORX47451.1 - 3.4e-47 160.4 0.1 2.1e-22 80.1 0.0 2.6 3 0 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 ORX47451.1 - 1e-20 74.7 4.8 1.4e-05 25.0 0.1 4.2 3 1 1 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 ORX47451.1 - 4.9e-20 71.4 8.1 5.5e-20 71.2 3.9 2.8 3 0 0 3 3 3 1 ABC transporter SMC_N PF02463.19 ORX47451.1 - 5.2e-11 42.4 0.3 0.0023 17.4 0.1 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX47451.1 - 1.5e-08 34.3 0.2 0.0025 17.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_33 PF13671.6 ORX47451.1 - 4.3e-08 33.4 0.0 0.001 19.3 0.0 2.6 3 0 0 3 3 2 2 AAA domain AAA_23 PF13476.6 ORX47451.1 - 3e-07 31.2 2.5 0.047 14.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain Dynamin_N PF00350.23 ORX47451.1 - 5.3e-07 29.8 0.8 0.015 15.4 0.1 3.6 2 1 1 3 3 3 2 Dynamin family AAA_28 PF13521.6 ORX47451.1 - 7.3e-07 29.6 0.0 0.0059 16.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ORX47451.1 - 3.1e-06 27.2 0.0 0.028 14.5 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX47451.1 - 3.7e-06 27.4 0.0 0.053 13.9 0.0 2.4 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX47451.1 - 6.1e-06 26.6 0.0 0.012 15.8 0.0 2.9 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX47451.1 - 7.2e-06 26.0 0.5 0.034 14.0 0.0 3.2 4 0 0 4 4 3 2 RsgA GTPase AAA_15 PF13175.6 ORX47451.1 - 1.3e-05 25.1 11.2 0.056 13.2 0.1 4.5 3 3 2 5 5 5 2 AAA ATPase domain NACHT PF05729.12 ORX47451.1 - 3.3e-05 23.9 0.1 0.34 10.8 0.1 2.7 2 0 0 2 2 2 2 NACHT domain AAA_24 PF13479.6 ORX47451.1 - 6e-05 22.9 0.6 0.39 10.4 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 ORX47451.1 - 0.00012 22.6 0.1 0.7 10.4 0.1 2.9 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 ORX47451.1 - 0.00028 20.9 0.0 4.6 7.3 0.0 3.9 4 0 0 4 4 4 0 AAA domain RNA_helicase PF00910.22 ORX47451.1 - 0.0007 20.0 0.0 1.8 9.0 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_27 PF13514.6 ORX47451.1 - 0.00089 18.9 0.0 2 7.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 ORX47451.1 - 0.00096 19.6 0.0 0.23 11.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ORX47451.1 - 0.0011 18.6 0.1 2.1 7.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ORX47451.1 - 0.0029 17.6 0.1 4.3 7.3 0.0 3.1 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 ORX47451.1 - 0.0033 17.2 0.2 4.8 6.9 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 ORX47451.1 - 0.0037 17.7 0.0 1.3 9.5 0.1 3.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Pox_A32 PF04665.12 ORX47451.1 - 0.0049 16.4 0.0 2 7.8 0.0 2.5 2 0 0 2 2 2 1 Poxvirus A32 protein TsaE PF02367.17 ORX47451.1 - 0.0059 16.6 0.2 2.2 8.3 0.0 3.2 2 1 1 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ORX47451.1 - 0.006 16.3 0.0 1.6 8.4 0.0 3.4 3 1 0 3 3 2 1 AAA domain VirE PF05272.11 ORX47451.1 - 0.012 15.3 0.1 3.3 7.4 0.0 2.8 3 0 0 3 3 3 0 Virulence-associated protein E ATP_bind_1 PF03029.17 ORX47451.1 - 0.013 15.3 0.2 3.9 7.2 0.0 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein FtsK_SpoIIIE PF01580.18 ORX47451.1 - 0.02 14.3 0.4 0.53 9.6 0.1 2.3 2 0 0 2 2 2 0 FtsK/SpoIIIE family Rad17 PF03215.15 ORX47451.1 - 0.021 14.7 0.0 0.42 10.5 0.0 2.5 2 0 0 2 2 2 0 Rad17 P-loop domain G-alpha PF00503.20 ORX47451.1 - 0.024 13.8 0.2 6.2 5.9 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit MukB PF04310.12 ORX47451.1 - 0.028 14.2 0.0 1.2 8.9 0.0 2.7 3 0 0 3 3 2 0 MukB N-terminal Septin PF00735.18 ORX47451.1 - 0.029 13.6 0.0 4.7 6.4 0.0 2.4 2 0 0 2 2 2 0 Septin MeaB PF03308.16 ORX47451.1 - 0.03 13.3 0.3 7.8 5.4 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Roc PF08477.13 ORX47451.1 - 0.032 14.4 0.0 8 6.7 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 ORX47451.1 - 0.033 14.4 0.1 2.4 8.4 0.0 2.9 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 ORX47451.1 - 0.05 13.7 4.1 3.2 7.8 0.0 3.1 3 1 1 4 4 3 0 Helicase HerA, central domain NB-ARC PF00931.22 ORX47451.1 - 0.052 12.7 0.0 4.9 6.3 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain AAA_7 PF12775.7 ORX47451.1 - 0.065 12.7 0.0 4.3 6.8 0.0 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region cobW PF02492.19 ORX47451.1 - 0.088 12.4 0.3 8 6.0 0.1 2.7 3 0 0 3 3 2 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 ORX47451.1 - 0.11 12.0 0.1 2.6 7.5 0.1 2.4 2 0 0 2 2 2 0 ADP-ribosylation factor family Mg_chelatase PF01078.21 ORX47451.1 - 0.16 11.4 0.1 8.1 5.8 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 ORX47451.1 - 0.18 11.4 1.5 11 5.6 0.0 2.8 3 0 0 3 3 2 0 SRP54-type protein, GTPase domain UBA2_C PF16195.5 ORX47453.1 - 0.44 11.3 0.0 0.44 11.3 0.0 2.4 3 0 0 3 3 3 0 SUMO-activating enzyme subunit 2 C-terminus Malic_M PF03949.15 ORX47454.1 - 2.1e-89 299.2 0.0 2.7e-89 298.8 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX47454.1 - 7.5e-74 247.5 0.0 1.3e-73 246.7 0.0 1.4 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TPR_1 PF00515.28 ORX47455.1 - 1.7e-11 43.4 5.7 8.8e-07 28.5 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX47455.1 - 2.6e-11 42.7 8.2 2.9e-05 23.8 0.1 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX47455.1 - 1.1e-10 40.8 3.3 0.0016 18.5 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX47455.1 - 4e-07 29.6 3.8 0.094 12.4 0.0 4.8 5 0 0 5 5 5 2 TPR repeat TPR_12 PF13424.6 ORX47455.1 - 2e-06 28.0 7.5 0.27 11.5 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX47455.1 - 1.9e-05 25.1 7.5 3.5 8.7 0.0 7.3 7 1 1 8 8 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX47455.1 - 6e-05 23.2 5.8 0.015 15.7 0.1 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX47455.1 - 0.00014 22.0 2.3 0.53 10.5 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX47455.1 - 0.016 15.8 3.1 16 6.4 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX47455.1 - 0.018 15.0 0.3 36 4.7 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX47455.1 - 0.027 15.0 5.3 7.7 7.1 0.0 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX47455.1 - 0.2 11.5 4.6 5.7 7.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX47455.1 - 2.7 8.7 9.7 1.4 9.7 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat PALP PF00291.25 ORX47456.1 - 1.7e-58 198.4 0.0 2.3e-58 197.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Cyclase PF04199.13 ORX47457.1 - 6.6e-14 52.3 0.1 8.7e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 Putative cyclase Exonuc_VII_L PF02601.15 ORX47458.1 - 0.24 10.9 2.6 0.26 10.8 2.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LIM_bind PF01803.16 ORX47460.1 - 5e-26 91.7 9.6 2.2e-22 79.8 0.2 3.5 3 1 1 4 4 4 2 LIM-domain binding protein Actin PF00022.19 ORX47461.1 - 2.4e-41 141.7 0.0 1.2e-40 139.4 0.0 1.8 1 1 0 1 1 1 1 Actin RhoGEF PF00621.20 ORX47462.1 - 2.8e-28 99.4 0.0 4.4e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain ECH_2 PF16113.5 ORX47463.1 - 5.7e-108 361.3 0.0 8.1e-108 360.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX47463.1 - 3.8e-27 95.2 0.0 3.7e-23 82.1 0.0 2.2 1 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase BRAP2 PF07576.12 ORX47464.1 - 1.6e-26 92.4 0.1 3.7e-26 91.2 0.1 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ORX47464.1 - 4e-20 71.9 4.4 4e-20 71.9 4.4 2.3 3 0 0 3 3 2 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 ORX47464.1 - 3.4e-07 30.5 1.1 3.4e-07 30.5 1.1 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX47464.1 - 1.8e-06 27.9 0.9 1.8e-06 27.9 0.9 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX47464.1 - 7.7e-06 26.1 1.2 7.7e-06 26.1 1.2 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX47464.1 - 8.6e-06 25.7 1.0 2.4e-05 24.3 1.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ORX47464.1 - 2.9e-05 23.7 5.9 2.9e-05 23.7 5.9 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX47464.1 - 4.1e-05 23.3 0.9 4.1e-05 23.3 0.9 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX47464.1 - 4.1e-05 23.4 0.2 4.1e-05 23.4 0.2 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX47464.1 - 0.00066 19.2 8.0 0.034 13.8 0.6 2.5 2 0 0 2 2 2 2 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ORX47464.1 - 0.005 16.8 4.6 0.005 16.8 4.6 2.5 1 1 1 2 2 2 1 zinc-RING finger domain zf-HC5HC2H_2 PF13832.6 ORX47464.1 - 0.0088 16.2 0.2 0.0088 16.2 0.2 2.6 1 1 1 2 2 2 1 PHD-zinc-finger like domain zf-C3HC4_4 PF15227.6 ORX47464.1 - 0.0091 16.1 0.3 0.0091 16.1 0.3 2.7 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-HC5HC2H PF13771.6 ORX47464.1 - 0.1 12.9 5.3 0.4 11.0 0.2 2.7 1 1 1 2 2 2 0 PHD-like zinc-binding domain Jnk-SapK_ap_N PF09744.9 ORX47464.1 - 0.59 10.3 12.1 1.1 9.4 12.1 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ERM PF00769.19 ORX47464.1 - 1 9.2 13.7 1.6 8.4 13.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family zf-C3HC4_3 PF13920.6 ORX47464.1 - 3.5 7.5 8.4 15 5.6 2.6 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SlyX PF04102.12 ORX47464.1 - 7 7.3 13.4 16 6.2 2.3 2.7 1 1 1 2 2 2 0 SlyX Csm1_N PF18504.1 ORX47464.1 - 9.3 6.7 14.0 1 9.7 4.5 3.0 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF4070 PF13282.6 ORX47465.1 - 0.048 13.8 1.2 0.058 13.5 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4070) DUF1757 PF08560.10 ORX47465.1 - 0.061 13.4 0.0 0.35 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1757) Minor_capsid_2 PF11114.8 ORX47465.1 - 0.16 12.0 3.2 2 8.5 0.1 2.5 2 1 0 2 2 2 0 Minor capsid protein Thi4 PF01946.17 ORX47466.1 - 1.5e-109 364.7 0.3 1.8e-109 364.5 0.3 1.0 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 ORX47466.1 - 7.8e-10 38.9 0.2 2.8e-07 30.5 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ORX47466.1 - 7.4e-08 31.9 0.4 9.2e-05 21.7 0.2 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ORX47466.1 - 7.8e-07 29.2 0.0 3.4e-06 27.2 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX47466.1 - 9.2e-07 28.4 0.1 1.2e-06 28.0 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX47466.1 - 2.9e-05 23.3 0.2 3.7e-05 22.9 0.2 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 ORX47466.1 - 5.9e-05 22.6 0.7 0.00012 21.6 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ORX47466.1 - 0.00027 20.1 2.2 0.12 11.4 0.1 2.5 3 0 0 3 3 3 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ORX47466.1 - 0.00082 19.4 0.1 0.0052 16.8 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ORX47466.1 - 0.0011 17.7 0.1 0.0027 16.5 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein GMC_oxred_N PF00732.19 ORX47466.1 - 0.0014 18.1 0.0 0.38 10.1 0.0 2.2 2 0 0 2 2 2 2 GMC oxidoreductase FAD_binding_3 PF01494.19 ORX47466.1 - 0.016 14.5 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Pyr_redox_3 PF13738.6 ORX47466.1 - 0.021 14.1 0.1 0.041 13.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX47466.1 - 0.21 10.7 0.0 0.33 10.1 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) RabGAP-TBC PF00566.18 ORX47467.1 - 1.7e-54 184.7 3.5 3e-54 183.9 0.1 2.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain HSP70 PF00012.20 ORX47468.1 - 1.4e-260 865.6 9.7 1.6e-260 865.5 9.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX47468.1 - 2.9e-17 62.5 0.2 3.7e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 ORX47468.1 - 0.019 15.4 2.2 3.4 8.1 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA DUF4473 PF14747.6 ORX47468.1 - 0.056 14.0 2.5 4.2 8.0 0.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4473) Hydantoinase_A PF01968.18 ORX47468.1 - 0.31 10.3 2.1 0.78 8.9 0.2 2.5 3 0 0 3 3 3 0 Hydantoinase/oxoprolinase Spore_GerAC PF05504.11 ORX47468.1 - 0.6 10.3 0.0 0.6 10.3 0.0 3.1 3 1 0 3 3 3 0 Spore germination B3/ GerAC like, C-terminal GHMP_kinases_N PF00288.26 ORX47469.1 - 3.7e-12 46.3 4.2 3.7e-12 46.3 4.2 1.8 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX47469.1 - 2.9e-08 33.9 0.0 6.3e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal DUF4708 PF15813.5 ORX47469.1 - 0.059 12.5 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4708) eIF-5_eIF-2B PF01873.17 ORX47470.1 - 1e-41 141.5 0.5 2.1e-41 140.5 0.1 1.7 2 0 0 2 2 2 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 ORX47470.1 - 0.0076 15.7 0.3 0.018 14.5 0.3 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding Utp14 PF04615.13 ORX47470.1 - 0.037 12.6 20.8 0.048 12.3 20.8 1.1 1 0 0 1 1 1 0 Utp14 protein Lar_restr_allev PF14354.6 ORX47470.1 - 0.044 14.2 0.2 0.16 12.4 0.2 2.0 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF2752 PF10825.8 ORX47470.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Arc_trans_TRASH PF08394.10 ORX47470.1 - 4.4 7.7 6.5 13 6.3 0.1 2.7 1 1 1 2 2 2 0 Archaeal TRASH domain ThiF PF00899.21 ORX47471.1 - 3.3e-109 363.9 0.0 1.1e-74 250.8 0.0 2.1 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 ORX47471.1 - 8.6e-98 327.3 0.0 1.3e-97 326.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 ORX47471.1 - 2.8e-35 120.9 1.4 4.1e-35 120.3 0.4 1.9 2 0 0 2 2 2 1 Ubiquitin fold domain E1_FCCH PF16190.5 ORX47471.1 - 1.1e-33 115.2 0.2 2.5e-33 114.1 0.2 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ORX47471.1 - 1.6e-24 85.8 0.1 4.2e-24 84.5 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle Shikimate_DH PF01488.20 ORX47471.1 - 0.053 13.6 0.5 0.56 10.3 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase DOT1 PF08123.13 ORX47473.1 - 3.2e-71 239.1 1.4 4e-71 238.8 1.4 1.1 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_31 PF13847.6 ORX47473.1 - 3.1e-06 27.0 0.0 5.5e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX47473.1 - 1.4e-05 25.7 0.0 3.8e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX47473.1 - 0.00018 22.1 0.0 0.00036 21.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ORX47473.1 - 0.00062 20.1 0.0 0.0012 19.1 0.0 1.5 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_23 PF13489.6 ORX47473.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX47473.1 - 0.0013 19.4 0.1 0.0057 17.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 ORX47473.1 - 0.016 14.5 0.0 0.048 12.9 0.0 1.7 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 ORX47473.1 - 0.03 13.6 0.2 0.22 10.8 0.2 2.0 1 1 0 1 1 1 0 O-methyltransferase domain MTS PF05175.14 ORX47473.1 - 0.068 12.7 0.0 0.12 12.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX47473.1 - 0.069 12.6 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase MetW PF07021.12 ORX47473.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Flavi_NS4A PF01350.17 ORX47474.1 - 0.089 12.7 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A Baculo_gp64 PF03273.13 ORX47475.1 - 0.14 10.9 0.1 0.18 10.5 0.1 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family DUF2059 PF09832.9 ORX47475.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2059) CDC50 PF03381.15 ORX47476.1 - 4.8e-87 292.0 1.0 6e-87 291.7 1.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family TrbC PF04956.13 ORX47476.1 - 0.035 14.3 0.2 0.069 13.4 0.2 1.4 1 0 0 1 1 1 0 TrbC/VIRB2 family DHHC PF01529.20 ORX47477.1 - 3.4e-37 127.5 9.6 3.4e-37 127.5 9.6 2.0 2 0 0 2 2 2 1 DHHC palmitoyltransferase Pox_A14 PF05767.12 ORX47477.1 - 0.14 12.3 3.4 1.4 9.1 0.2 2.5 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF1272 PF06906.11 ORX47477.1 - 1.5 9.0 7.1 4 7.6 7.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) PBP1_TM PF14812.6 ORX47477.1 - 4.4 7.7 5.5 6.6 7.2 0.2 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Tim17 PF02466.19 ORX47478.1 - 2.5e-26 92.2 7.9 3.9e-26 91.6 7.9 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family CH PF00307.31 ORX47481.1 - 3.1e-11 43.4 0.0 3.7e-11 43.2 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ORX47481.1 - 0.0013 18.5 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 CAMSAP CH domain CDC24 PF06395.11 ORX47481.1 - 0.003 17.8 0.0 0.0039 17.4 0.0 1.2 1 0 0 1 1 1 1 CDC24 Calponin Pkinase PF00069.25 ORX47482.1 - 1.5e-64 217.9 0.0 1.9e-64 217.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47482.1 - 9e-48 162.8 0.0 1.1e-47 162.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX47482.1 - 8.7e-06 25.3 0.0 0.039 13.3 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX47482.1 - 0.0006 19.5 0.1 0.0019 17.9 0.1 1.6 1 1 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX47482.1 - 0.02 13.7 0.0 0.037 12.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX47482.1 - 0.021 14.4 0.1 0.028 13.9 0.1 1.1 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 ORX47482.1 - 0.13 11.3 0.5 0.23 10.5 0.2 1.4 2 0 0 2 2 2 0 Seadornavirus VP7 ABC1 PF03109.16 ORX47482.1 - 0.15 12.3 0.0 0.25 11.5 0.0 1.3 1 0 0 1 1 1 0 ABC1 family Abhydrolase_6 PF12697.7 ORX47483.1 - 2e-25 90.7 0.0 2.8e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX47483.1 - 3e-09 36.5 0.1 5e-09 35.8 0.1 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX47483.1 - 5.2e-09 36.1 0.2 1.1e-08 35.1 0.2 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ORX47483.1 - 0.0013 17.7 0.0 0.0018 17.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Thioesterase PF00975.20 ORX47483.1 - 0.0051 17.0 0.0 0.0084 16.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ORX47483.1 - 0.007 16.2 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_2 PF02230.16 ORX47483.1 - 0.01 15.7 0.3 0.96 9.2 0.3 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase PGAP1 PF07819.13 ORX47483.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 ORX47483.1 - 0.074 12.8 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_32 PF13679.6 ORX47483.1 - 0.2 11.6 0.0 0.38 10.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain zf-TRAF PF02176.18 ORX47484.1 - 3.8e-16 59.5 30.0 1.8e-09 38.1 5.3 3.6 1 1 2 3 3 3 3 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ORX47484.1 - 1.4e-07 31.2 9.6 1.4e-07 31.2 9.6 3.6 2 1 1 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX47484.1 - 3.3e-07 30.5 9.6 3.3e-07 30.5 9.6 3.6 2 1 0 2 2 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX47484.1 - 9.2e-07 28.6 6.5 9.2e-07 28.6 6.5 3.4 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX47484.1 - 1.1e-06 28.6 12.5 1.1e-06 28.6 12.5 2.5 3 0 0 3 3 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX47484.1 - 1.3e-05 24.9 9.7 1.3e-05 24.9 9.7 3.2 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX47484.1 - 1.5e-05 25.2 4.5 1.5e-05 25.2 4.5 3.9 2 1 1 3 3 2 1 RING-H2 zinc finger domain U-box PF04564.15 ORX47484.1 - 0.00037 20.6 0.4 0.014 15.6 0.0 2.9 2 1 1 3 3 3 1 U-box domain zf-RING_5 PF14634.6 ORX47484.1 - 0.00051 19.9 10.1 0.00051 19.9 10.1 4.0 2 2 1 3 3 2 1 zinc-RING finger domain MAD PF05557.13 ORX47484.1 - 0.002 16.6 2.0 0.002 16.6 2.0 1.4 2 0 0 2 2 2 1 Mitotic checkpoint protein zf-C3HC4_4 PF15227.6 ORX47484.1 - 0.002 18.3 12.1 0.002 18.3 12.1 2.9 2 1 0 2 2 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ORX47484.1 - 0.0022 17.8 8.6 0.0022 17.8 8.6 3.3 2 1 1 3 3 2 1 Prokaryotic RING finger family 4 zf-TRAF_2 PF15965.5 ORX47484.1 - 0.0035 17.8 2.4 0.0035 17.8 2.4 3.8 1 1 2 3 3 3 2 TRAF-like zinc-finger zf-ANAPC11 PF12861.7 ORX47484.1 - 0.0061 16.6 2.6 0.0061 16.6 2.6 2.9 3 0 0 3 3 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-ACC PF17848.1 ORX47484.1 - 0.063 13.4 0.2 0.063 13.4 0.2 4.3 4 0 0 4 4 3 0 Acetyl-coA carboxylase zinc finger domain bZIP_1 PF00170.21 ORX47484.1 - 0.082 13.0 3.5 2.5 8.3 0.3 2.7 2 0 0 2 2 2 0 bZIP transcription factor ZapB PF06005.12 ORX47484.1 - 0.19 12.2 8.8 2 8.9 1.8 2.6 2 0 0 2 2 2 0 Cell division protein ZapB HALZ PF02183.18 ORX47484.1 - 0.38 11.0 3.8 7.7 6.8 0.4 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper Sina PF03145.16 ORX47484.1 - 1.3 8.9 32.1 0.16 11.9 3.9 4.6 2 1 3 5 5 4 0 Seven in absentia protein family JIP_LZII PF16471.5 ORX47484.1 - 3.3 7.9 8.4 27 5.0 0.7 3.5 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II HAP1_N PF04849.13 ORX47484.1 - 4.9 6.3 14.8 0.069 12.3 0.9 2.6 3 0 0 3 3 3 0 HAP1 N-terminal conserved region DASH_Dad3 PF08656.10 ORX47485.1 - 3e-12 46.4 0.2 3.4e-12 46.3 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 LPD14 PF18827.1 ORX47485.1 - 0.11 12.8 0.3 0.12 12.6 0.3 1.1 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 14 XPG_N PF00752.17 ORX47488.1 - 1.5e-38 131.3 0.9 3.3e-37 127.0 0.0 2.3 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 ORX47488.1 - 6.7e-32 109.7 0.6 1.8e-31 108.3 0.0 2.0 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 ORX47488.1 - 0.00081 19.9 0.0 0.0049 17.4 0.0 2.2 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold S4 PF01479.25 ORX47489.1 - 2.2e-12 46.5 1.4 2.2e-12 46.5 1.4 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 ORX47489.1 - 0.0001 23.1 0.1 0.00024 22.0 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 ORX47490.1 - 2.6e-45 152.4 5.0 2.6e-45 152.4 5.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 ORX47490.1 - 0.04 13.5 0.0 0.049 13.2 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 PTH2 PF01981.16 ORX47491.1 - 1.9e-19 70.1 0.2 2.2e-19 69.8 0.2 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DHQS PF01959.16 ORX47491.1 - 0.044 12.7 0.1 0.054 12.4 0.1 1.0 1 0 0 1 1 1 0 3-dehydroquinate synthase II TRM PF02005.16 ORX47492.1 - 2.7e-135 451.4 0.0 3.3e-135 451.1 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 ORX47492.1 - 0.0052 16.5 0.1 0.0099 15.6 0.1 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 ORX47492.1 - 0.073 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 WD40 PF00400.32 ORX47493.1 - 2.4e-34 116.8 25.7 9.9e-06 26.2 0.6 10.1 11 0 0 11 11 11 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX47493.1 - 2.1e-18 66.4 0.5 4.6e-05 23.6 0.0 6.4 3 3 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX47493.1 - 1e-05 25.0 0.0 0.013 14.9 0.0 3.1 1 1 1 2 2 2 1 WD40-like domain RAB3GAP2_N PF14655.6 ORX47493.1 - 1.5e-05 24.5 0.0 0.01 15.2 0.0 2.7 3 0 0 3 3 3 2 Rab3 GTPase-activating protein regulatory subunit N-terminus PQQ_3 PF13570.6 ORX47493.1 - 0.02 15.4 3.2 3 8.4 0.1 4.6 5 0 0 5 5 5 0 PQQ-like domain PQQ PF01011.21 ORX47493.1 - 0.097 12.6 4.0 11 6.2 0.1 4.2 4 0 0 4 4 4 0 PQQ enzyme repeat Ribosomal_S19e PF01090.19 ORX47494.1 - 5.8e-60 200.9 0.3 6.5e-60 200.8 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Pkinase PF00069.25 ORX47495.1 - 3.2e-55 187.3 0.0 3.9e-55 187.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47495.1 - 6.2e-44 150.2 0.0 7.9e-44 149.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX47495.1 - 2e-07 30.2 0.0 4.7e-07 28.9 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX47495.1 - 0.00035 20.0 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ORX47495.1 - 0.031 13.3 0.0 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ORX47495.1 - 0.19 10.6 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Es2 PF09751.9 ORX47497.1 - 1.4e-51 176.6 13.9 3.4e-17 63.3 0.1 4.1 1 1 2 3 3 3 3 Nuclear protein Es2 DUF1688 PF07958.11 ORX47497.1 - 0.051 12.3 0.0 0.075 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1688) Sec63 PF02889.16 ORX47498.1 - 8.4e-24 84.1 0.0 2.2e-23 82.8 0.0 1.6 2 1 0 2 2 2 1 Sec63 Brl domain DnaJ PF00226.31 ORX47498.1 - 1.5e-21 76.3 1.8 6.1e-21 74.3 1.8 2.2 1 0 0 1 1 1 1 DnaJ domain DUF1804 PF08822.11 ORX47498.1 - 0.035 14.1 2.2 0.037 14.0 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) HemY_N PF07219.13 ORX47498.1 - 0.49 10.6 4.4 1.5 9.0 0.0 3.1 3 0 0 3 3 3 0 HemY protein N-terminus SRP68 PF16969.5 ORX47499.1 - 9.7e-107 358.3 22.3 1.1e-104 351.5 22.3 2.0 1 1 0 1 1 1 1 RNA-binding signal recognition particle 68 BLI1 PF17324.2 ORX47499.1 - 0.0022 18.7 1.0 0.0077 16.9 1.0 1.9 1 0 0 1 1 1 1 BLOC-1 interactor 1 zf-C2H2 PF00096.26 ORX47500.1 - 1.2e-10 41.3 24.9 0.00025 21.3 1.3 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX47500.1 - 3.8e-09 36.6 28.7 1.7e-05 25.0 4.6 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX47500.1 - 1.4e-06 28.7 25.0 0.0092 16.7 0.9 4.1 3 1 1 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 ORX47500.1 - 0.026 15.2 0.8 2 9.1 0.0 2.7 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX47500.1 - 0.031 14.6 3.2 5.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX47500.1 - 0.082 12.7 0.1 0.082 12.7 0.1 4.7 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 ORX47500.1 - 0.1 12.9 9.7 1.5 9.2 0.2 3.5 2 1 2 4 4 4 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX47500.1 - 6.7 6.8 12.8 5.5 7.1 0.1 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Ras PF00071.22 ORX47501.1 - 2.3e-53 180.1 0.3 2.6e-53 179.9 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX47501.1 - 1.3e-28 99.6 0.0 2.4e-28 98.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX47501.1 - 4e-11 42.7 0.0 4.9e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX47501.1 - 2.3e-05 24.4 0.0 4.4e-05 23.5 0.0 1.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX47501.1 - 4e-05 23.2 0.0 7.3e-05 22.4 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX47501.1 - 6.1e-05 22.5 0.2 7.4e-05 22.2 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX47501.1 - 0.014 15.3 0.1 0.6 10.0 0.1 2.3 1 1 0 2 2 2 0 RsgA GTPase cobW PF02492.19 ORX47501.1 - 0.062 12.9 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Alk_phosphatase PF00245.20 ORX47502.1 - 2.2e-100 336.6 0.2 2.7e-100 336.2 0.2 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 ORX47502.1 - 0.045 13.1 0.0 0.11 11.8 0.0 1.6 2 0 0 2 2 2 0 Metalloenzyme superfamily DUF802 PF05650.11 ORX47502.1 - 0.32 11.5 5.6 6.4 7.3 0.3 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF802) FtsJ PF01728.19 ORX47503.1 - 1.6e-69 233.5 0.0 2e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase SWIRM PF04433.17 ORX47504.1 - 1.5e-28 98.9 0.1 1.5e-28 98.9 0.1 2.1 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 ORX47504.1 - 1.4e-09 38.0 0.0 3e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX47504.1 - 9.5e-06 25.8 0.0 9.5e-06 25.8 0.0 2.3 2 1 0 2 2 2 1 Myb-like DNA-binding domain Asparaginase_2 PF01112.18 ORX47504.1 - 2.9 6.8 7.7 5.9 5.8 7.7 1.4 1 0 0 1 1 1 0 Asparaginase EMP70 PF02990.16 ORX47505.1 - 9.4e-150 499.7 18.9 1.2e-149 499.4 18.9 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 E1-E2_ATPase PF00122.20 ORX47509.1 - 2e-50 170.8 2.4 2e-50 170.8 2.4 3.6 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ORX47509.1 - 6.8e-23 82.1 0.0 1.8e-22 80.7 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX47509.1 - 8.3e-12 44.6 0.0 2.2e-11 43.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 ORX47509.1 - 0.0084 15.8 7.3 0.0084 15.8 7.3 2.5 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase_3 PF08282.12 ORX47509.1 - 0.023 14.4 0.0 0.12 12.1 0.1 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX47509.1 - 0.15 12.1 0.0 0.36 10.9 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) FLYWCH_u PF16662.5 ORX47509.1 - 0.21 11.7 1.1 28 4.9 0.0 2.7 3 0 0 3 3 3 0 FLYWCH-type zinc finger-containing protein 1 DUF4998 PF16389.5 ORX47510.1 - 0.1 12.2 0.1 0.14 11.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function Chitin_synth_2 PF03142.15 ORX47511.1 - 6e-282 935.9 0.6 7.8e-282 935.5 0.6 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX47511.1 - 1.3e-14 54.6 0.0 1.7e-11 44.5 0.0 2.4 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX47511.1 - 1.2e-10 41.6 0.9 2.9e-10 40.4 0.9 1.7 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX47511.1 - 0.0021 17.9 0.0 0.32 10.8 0.0 2.7 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX47511.1 - 0.006 16.1 0.1 0.31 10.5 0.1 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 PX PF00787.24 ORX47512.1 - 2.8e-20 72.4 0.5 7.1e-20 71.1 0.1 1.9 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 ORX47512.1 - 1.4e-11 44.4 5.3 4.3e-05 23.2 0.2 2.4 3 0 0 3 3 3 2 Vps5 C terminal like BAR PF03114.18 ORX47512.1 - 7.5e-06 25.8 4.4 0.00059 19.5 0.1 2.5 2 0 0 2 2 2 2 BAR domain Peptidase_C10 PF01640.17 ORX47512.1 - 0.0024 18.2 1.5 0.0048 17.2 1.5 1.4 1 0 0 1 1 1 1 Peptidase C10 family CNOT1_TTP_bind PF16417.5 ORX47512.1 - 0.029 13.6 0.2 0.16 11.1 0.1 2.2 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 TTP binding domain BAR_3_WASP_bdg PF10456.9 ORX47512.1 - 0.079 12.4 2.6 0.29 10.6 0.1 2.4 2 0 0 2 2 2 0 WASP-binding domain of Sorting nexin protein HAUS5 PF14817.6 ORX47512.1 - 0.093 11.5 2.2 2.4 6.8 0.1 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 5 BLOC1_2 PF10046.9 ORX47512.1 - 0.26 11.6 6.2 4.1 7.8 0.1 4.2 4 2 1 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FAM92 PF06730.11 ORX47512.1 - 0.3 10.5 4.4 0.53 9.7 0.3 2.7 3 0 0 3 3 3 0 FAM92 protein MCU PF04678.13 ORX47512.1 - 2.4 8.2 5.3 1.5 8.9 2.1 2.3 2 1 1 3 3 3 0 Mitochondrial calcium uniporter Borrelia_lipo_1 PF05714.11 ORX47512.1 - 3.5 7.4 7.8 0.88 9.3 0.4 2.6 3 0 0 3 3 3 0 Borrelia burgdorferi virulent strain associated lipoprotein ThiF PF00899.21 ORX47513.1 - 1.7e-37 129.1 0.0 2.6e-37 128.5 0.0 1.3 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 ORX47513.1 - 0.011 16.0 0.4 0.037 14.3 0.4 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3HCDH_N PF02737.18 ORX47513.1 - 0.011 15.6 0.0 0.5 10.2 0.0 2.4 2 1 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ORX47513.1 - 0.084 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA UDPG_MGDP_dh_N PF03721.14 ORX47513.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 ORX47513.1 - 0.11 11.7 0.1 0.17 11.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DAO PF01266.24 ORX47513.1 - 0.17 11.4 0.4 0.55 9.8 0.3 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX47513.1 - 0.25 11.8 0.6 3 8.3 0.6 2.4 1 1 0 1 1 1 0 Putative NAD(P)-binding IQ PF00612.27 ORX47514.1 - 0.06 13.2 0.2 0.17 11.8 0.2 1.8 1 0 0 1 1 1 0 IQ calmodulin-binding motif HECT PF00632.25 ORX47515.1 - 4.5e-91 305.5 0.0 5.4e-91 305.3 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Statherin PF03875.13 ORX47515.1 - 0.01 15.9 0.1 0.038 14.1 0.0 1.9 2 0 0 2 2 2 1 Statherin PAPA-1 PF04795.12 ORX47516.1 - 7.6e-21 74.7 7.9 7.6e-21 74.7 7.9 1.7 2 0 0 2 2 2 1 PAPA-1-like conserved region zf-HIT PF04438.16 ORX47516.1 - 0.018 14.9 0.4 0.028 14.3 0.4 1.3 1 0 0 1 1 1 0 HIT zinc finger Asp-B-Hydro_N PF05279.11 ORX47516.1 - 0.33 11.0 6.9 0.39 10.7 6.9 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Spt5_N PF11942.8 ORX47516.1 - 3.8 8.6 10.4 6.1 7.9 10.4 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal NDUFB10 PF10249.9 ORX47517.1 - 4.8e-08 33.6 1.8 5e-08 33.5 1.8 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit 10 MFS_1 PF07690.16 ORX47518.1 - 3.1e-36 125.0 40.0 3.1e-36 125.0 38.8 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX47518.1 - 1.4e-07 31.2 4.0 1.4e-07 31.2 4.0 2.8 2 1 1 3 3 3 1 Uncharacterised MFS-type transporter YbfB zf-C2H2_jaz PF12171.8 ORX47519.1 - 0.051 13.9 1.5 0.051 13.9 1.5 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ORX47519.1 - 0.07 13.6 1.4 0.07 13.6 1.4 3.4 3 0 0 3 3 3 0 Zinc finger, C2H2 type DNA_primase_lrg PF04104.14 ORX47519.1 - 0.13 11.6 0.7 0.21 11.0 0.7 1.3 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Zn_ribbon_SprT PF17283.2 ORX47519.1 - 0.17 11.8 3.1 0.47 10.4 3.1 1.7 1 0 0 1 1 1 0 SprT-like zinc ribbon domain zf-C2H2_4 PF13894.6 ORX47519.1 - 0.33 11.9 13.1 1.8 9.6 1.4 4.3 2 2 1 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX47519.1 - 0.86 10.1 4.9 1.3 9.6 0.2 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-CHY PF05495.12 ORX47519.1 - 8.6 6.9 9.9 0.09 13.3 1.9 1.9 2 0 0 2 2 2 0 CHY zinc finger DUF1612 PF07756.12 ORX47523.1 - 0.13 12.6 0.1 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) LytR_C PF13399.6 ORX47524.1 - 0.091 13.8 0.3 0.13 13.3 0.3 1.6 1 1 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator Cnn_1N PF07989.11 ORX47524.1 - 0.26 11.5 4.1 3.6 7.8 0.7 2.4 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 MFS_1 PF07690.16 ORX47526.1 - 5e-31 107.9 31.3 5e-31 107.9 31.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Hydrolase_6 PF13344.6 ORX47527.1 - 5.9e-32 109.8 0.1 1.6e-31 108.4 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX47527.1 - 3.8e-19 68.5 0.0 7.9e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX47527.1 - 3.4e-14 53.6 0.0 5.4e-14 53.0 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX47527.1 - 3.1e-10 40.4 0.2 7e-05 23.0 0.0 2.5 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase OrfB_Zn_ribbon PF07282.11 ORX47528.1 - 0.0031 17.4 0.9 0.0066 16.4 0.9 1.7 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Anti-TRAP PF15777.5 ORX47528.1 - 0.022 14.7 0.1 0.17 11.9 0.1 2.1 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein TF_Zn_Ribbon PF08271.12 ORX47528.1 - 0.052 13.1 0.1 0.052 13.1 0.1 1.6 2 0 0 2 2 2 0 TFIIB zinc-binding 4HBT PF03061.22 ORX47679.1 - 1.7e-13 50.7 0.0 3.2e-13 49.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily OLF PF02191.16 ORX47679.1 - 0.023 14.2 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Olfactomedin-like domain Glyco_trans_2_3 PF13632.6 ORX47680.1 - 7.1e-16 58.7 0.7 7.1e-16 58.7 0.7 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 M157 PF11624.8 ORX47680.1 - 0.1 11.9 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 MHC class I-like protein M157 Vfa1 PF08432.10 ORX47681.1 - 1e-30 107.4 5.2 1.5e-30 106.9 5.2 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Ig_6 PF18452.1 ORX47681.1 - 0.071 12.7 0.1 0.19 11.3 0.1 1.7 1 0 0 1 1 1 0 Immunoglobulin domain SpoIIIAH PF12685.7 ORX47681.1 - 0.077 12.8 3.8 0.1 12.5 3.8 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF809 PF05663.11 ORX47681.1 - 1.4 9.1 4.0 2.3 8.4 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CDC45 PF02724.14 ORX47681.1 - 2.7 6.2 11.0 3.4 5.8 11.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ORX47681.1 - 3.8 6.2 5.2 4.8 5.8 5.2 1.2 1 0 0 1 1 1 0 Presenilin F-box-like PF12937.7 ORX47683.1 - 0.067 13.1 1.0 0.13 12.2 1.0 1.4 1 0 0 1 1 1 0 F-box-like GRAM PF02893.20 ORX47684.1 - 9.4e-21 73.8 0.2 1.6e-20 73.1 0.2 1.4 1 0 0 1 1 1 1 GRAM domain Ser_hydrolase PF06821.13 ORX47685.1 - 0.026 14.4 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase DUF726 PF05277.12 ORX47685.1 - 0.089 11.7 0.0 0.2 10.6 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF726) Arrestin_C PF02752.22 ORX47686.1 - 2.9e-22 79.5 0.5 1.9e-19 70.5 0.1 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX47686.1 - 3.3e-15 56.4 0.0 1.5e-14 54.3 0.0 2.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 ORX47686.1 - 1.5e-05 24.3 0.1 0.0092 15.2 0.0 2.4 1 1 0 2 2 2 2 Rgp1 LDB19 PF13002.7 ORX47686.1 - 0.0071 16.1 0.0 0.016 14.9 0.0 1.6 1 0 0 1 1 1 1 Arrestin_N terminal like FAM176 PF14851.6 ORX47689.1 - 0.0029 17.3 0.4 0.0029 17.3 0.4 2.5 2 1 1 3 3 3 1 FAM176 family Mucin PF01456.17 ORX47689.1 - 0.012 15.5 2.0 0.012 15.5 2.0 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein Raftlin PF15250.6 ORX47689.1 - 0.019 13.7 11.1 0.21 10.3 5.1 2.0 2 0 0 2 2 2 0 Raftlin FAM209 PF15206.6 ORX47689.1 - 0.039 13.7 0.2 0.039 13.7 0.2 1.9 2 0 0 2 2 2 0 FAM209 family Herpes_LMP1 PF05297.11 ORX47689.1 - 0.095 11.9 0.3 0.13 11.4 0.3 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Cadherin_C_2 PF16492.5 ORX47689.1 - 0.2 12.4 0.7 0.53 11.1 0.7 1.8 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Ac76 PF05814.11 ORX47689.1 - 0.3 11.1 0.1 0.3 11.1 0.1 2.0 2 1 0 2 2 2 0 Orf76 (Ac76) SpoIIIAH PF12685.7 ORX47689.1 - 0.94 9.3 14.8 12 5.7 14.8 2.1 1 1 0 1 1 1 0 SpoIIIAH-like protein EphA2_TM PF14575.6 ORX47689.1 - 1.3 10.0 7.1 0.19 12.6 1.7 2.5 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain CLN3 PF02487.17 ORX47689.1 - 1.4 7.9 10.3 0.054 12.5 2.6 2.0 2 0 0 2 2 2 0 CLN3 protein EVI2A PF05399.11 ORX47689.1 - 1.6 8.2 10.7 0.2 11.2 6.1 1.7 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) NPR3 PF03666.13 ORX47689.1 - 7.8 5.2 22.0 0.18 10.5 11.3 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Band_3_cyto PF07565.13 ORX47689.1 - 8.9 6.0 15.9 2.1 8.1 9.1 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CTP_transf_like PF01467.26 ORX47691.1 - 1.9e-19 70.3 0.0 2.3e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Sld5 PF05916.11 ORX47692.1 - 4e-05 24.0 0.5 6.8e-05 23.3 0.5 1.4 1 0 0 1 1 1 1 GINS complex protein MutS_V PF00488.21 ORX47693.1 - 2e-74 249.7 0.3 5e-74 248.4 0.3 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX47693.1 - 3.2e-35 122.1 0.2 1.3e-34 120.1 0.1 2.2 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 ORX47693.1 - 1e-28 99.8 0.2 8.8e-28 96.8 0.1 2.6 3 0 0 3 3 3 1 MutS domain I MutS_IV PF05190.18 ORX47693.1 - 1.6e-10 41.1 0.0 4.4e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 MutS family domain IV MutS_II PF05188.17 ORX47693.1 - 2.5e-10 40.7 0.3 1.1e-09 38.7 0.0 2.3 2 0 0 2 2 2 1 MutS domain II SF3b1 PF08920.10 ORX47694.1 - 8.6e-39 132.7 19.2 8.2e-38 129.5 5.2 3.5 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT PF02985.22 ORX47694.1 - 5.1e-10 38.7 4.2 0.31 11.4 0.1 8.8 10 0 0 10 10 9 2 HEAT repeat HEAT_2 PF13646.6 ORX47694.1 - 1.6e-07 31.6 10.3 0.24 11.8 0.1 7.5 5 2 4 9 9 9 3 HEAT repeats HEAT_EZ PF13513.6 ORX47694.1 - 5.5e-07 30.0 12.8 0.21 12.1 0.0 7.7 9 1 1 10 10 10 3 HEAT-like repeat Adaptin_N PF01602.20 ORX47694.1 - 9.2e-05 21.2 2.7 0.085 11.4 0.1 3.1 2 1 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX47694.1 - 0.00059 20.4 5.5 1.4 9.6 0.0 4.7 6 0 0 6 6 5 2 Vacuolar 14 Fab1-binding region Dopey_N PF04118.14 ORX47694.1 - 0.0014 17.8 0.7 0.53 9.4 0.0 3.5 3 1 0 3 3 3 1 Dopey, N-terminal Cnd1 PF12717.7 ORX47694.1 - 0.0045 17.1 9.3 0.48 10.4 0.0 5.2 6 1 1 7 7 7 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX47694.1 - 0.012 15.2 0.3 20 4.7 0.0 3.8 5 0 0 5 5 5 0 CLASP N terminal TAF6_C PF07571.13 ORX47694.1 - 0.056 13.8 0.0 0.3 11.5 0.0 2.4 2 0 0 2 2 1 0 TAF6 C-terminal HEAT repeat domain MMS19_C PF12460.8 ORX47694.1 - 0.15 11.1 0.0 48 2.9 0.0 3.6 3 1 0 3 3 3 0 RNAPII transcription regulator C-terminal Arm PF00514.23 ORX47694.1 - 0.67 10.1 3.6 52 4.1 0.0 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Tim17 PF02466.19 ORX47695.1 - 1e-10 42.0 8.6 1e-10 42.0 8.6 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family Serine_protease PF18405.1 ORX47695.1 - 0.26 10.4 1.2 0.43 9.7 0.2 1.7 1 1 1 2 2 2 0 Gammaproteobacterial serine protease RRM_1 PF00076.22 ORX47696.1 - 1e-84 278.4 1.0 5.2e-21 74.2 0.0 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX47696.1 - 1.9e-21 76.0 0.6 6.4e-21 74.3 0.2 2.1 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ORX47696.1 - 7.7e-09 35.2 0.0 0.038 13.6 0.0 4.3 1 1 3 4 4 4 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ORX47696.1 - 1.2e-06 28.5 0.5 1.3 9.1 0.0 3.6 3 0 0 3 3 3 3 RNA binding motif RRM_7 PF16367.5 ORX47696.1 - 4.6e-06 26.7 0.6 1.5 9.0 0.0 4.9 4 2 0 4 4 4 2 RNA recognition motif SET_assoc PF11767.8 ORX47696.1 - 8.2e-06 25.4 0.7 2 8.1 0.0 3.8 4 0 0 4 4 4 2 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.6 ORX47696.1 - 2.9e-05 24.0 0.0 2.2 8.3 0.0 4.5 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif PHM7_cyt PF14703.6 ORX47696.1 - 0.0014 18.9 0.0 2.1 8.6 0.0 4.1 4 0 0 4 4 4 1 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 ORX47696.1 - 0.0028 17.3 2.6 18 5.1 0.1 3.9 4 0 0 4 4 4 0 Ribonuclease B OB domain Limkain-b1 PF11608.8 ORX47696.1 - 0.0031 17.5 2.8 0.46 10.6 0.2 3.4 3 0 0 3 3 3 1 Limkain b1 RRM_occluded PF16842.5 ORX47696.1 - 0.02 14.7 0.0 5.5 6.9 0.0 3.3 3 0 0 3 3 3 0 Occluded RNA-recognition motif Ring_hydroxyl_A PF00848.19 ORX47696.1 - 0.66 9.9 4.8 1.7 8.6 1.8 2.3 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) adh_short PF00106.25 ORX47697.1 - 7.3e-38 130.0 1.1 8.9e-38 129.7 1.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX47697.1 - 5.7e-28 98.1 0.2 6.9e-28 97.8 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX47697.1 - 2.8e-12 46.9 0.2 3.4e-12 46.6 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX47697.1 - 0.0015 18.0 0.1 0.0027 17.2 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RRM_9 PF18444.1 ORX47698.1 - 0.021 14.7 0.1 0.49 10.3 0.1 2.9 2 1 0 2 2 2 0 RNA recognition motif adh_short_C2 PF13561.6 ORX47699.1 - 1.8e-56 191.3 1.4 2.4e-56 190.9 1.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX47699.1 - 4e-43 147.1 0.7 5.1e-43 146.8 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX47699.1 - 5.8e-16 58.9 0.7 7.7e-16 58.5 0.7 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ORX47699.1 - 0.0019 18.4 0.4 0.0036 17.5 0.4 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain PCMT PF01135.19 ORX47699.1 - 0.017 14.9 0.1 0.027 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Polysacc_synt_2 PF02719.15 ORX47699.1 - 0.025 13.7 0.4 0.038 13.1 0.4 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein His_biosynth PF00977.21 ORX47699.1 - 0.035 13.6 0.3 0.055 12.9 0.3 1.3 1 1 0 1 1 1 0 Histidine biosynthesis protein PA PF02225.22 ORX47699.1 - 0.049 13.7 0.3 0.1 12.6 0.3 1.5 1 0 0 1 1 1 0 PA domain CRIM PF16978.5 ORX47700.1 - 1.1e-38 132.6 0.0 3.7e-38 130.8 0.0 2.0 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 ORX47700.1 - 1e-22 80.5 0.2 1.8e-22 79.7 0.2 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RBD PF02196.15 ORX47700.1 - 0.0015 18.5 0.1 0.0087 16.1 0.0 2.2 2 0 0 2 2 2 1 Raf-like Ras-binding domain SLC35F PF06027.12 ORX47701.1 - 1.5e-101 339.9 23.9 1.8e-101 339.6 23.9 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 ORX47701.1 - 1.4e-09 38.2 31.0 7.6e-06 26.1 9.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 ORX47701.1 - 4.9e-07 29.0 8.3 4.9e-07 29.0 8.3 1.8 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like UAA PF08449.11 ORX47701.1 - 0.00021 20.6 19.7 0.00037 19.8 19.7 1.4 1 1 0 1 1 1 1 UAA transporter family Sec62 PF03839.16 ORX47701.1 - 1.9 8.0 9.7 4 6.9 9.7 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 TBP PF00352.21 ORX47702.1 - 8.6e-69 227.5 0.1 1.9e-33 114.3 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 ORX47702.1 - 1.3e-05 25.2 0.1 0.13 12.4 0.0 2.8 3 1 0 3 3 3 2 Domain of unknown function (DUF3378) PX PF00787.24 ORX47703.1 - 8.6e-16 57.9 0.1 1.8e-15 56.9 0.1 1.6 1 0 0 1 1 1 1 PX domain XhlA PF10779.9 ORX47703.1 - 0.03 14.5 2.3 0.093 12.9 2.3 1.8 1 0 0 1 1 1 0 Haemolysin XhlA PEP-utilisers_N PF05524.13 ORX47703.1 - 0.41 10.8 3.0 0.3 11.3 0.8 1.8 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Sas6_CC PF18594.1 ORX47703.1 - 0.54 10.1 6.9 8.5 6.3 0.3 2.8 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain DUF745 PF05335.13 ORX47703.1 - 3.8 7.2 12.3 9.7 5.9 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) PP2C PF00481.21 ORX47704.1 - 4.5e-65 219.8 0.0 5.1e-65 219.7 0.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PCRF PF03462.18 ORX47705.1 - 2.5e-59 200.4 0.9 2.5e-59 200.4 0.9 1.5 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 ORX47705.1 - 8.6e-42 141.8 3.0 2.1e-41 140.5 3.0 1.7 1 0 0 1 1 1 1 RF-1 domain HMD PF03201.16 ORX47705.1 - 0.05 13.8 0.0 19 5.6 0.0 2.6 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase CENP-H PF05837.12 ORX47705.1 - 7.6 7.0 9.5 8.4 6.8 4.3 2.5 2 1 0 2 2 2 0 Centromere protein H (CENP-H) DCP2 PF05026.13 ORX47706.1 - 9.7e-28 96.3 0.2 1.9e-27 95.4 0.2 1.5 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 ORX47706.1 - 3e-15 56.4 0.0 4.6e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 ORX47706.1 - 0.0017 18.0 0.0 0.0035 16.9 0.0 1.6 1 1 0 1 1 1 1 Nucleotide hydrolase FERM_M PF00373.18 ORX47706.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 FERM central domain SERTA PF06031.13 ORX47707.1 - 0.0035 17.0 0.1 0.01 15.5 0.0 1.8 2 0 0 2 2 2 1 SERTA motif Zn_clus PF00172.18 ORX47708.1 - 1.1e-07 31.9 11.6 4.1e-07 30.0 11.6 2.0 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX47708.1 - 0.014 14.4 0.0 0.014 14.4 0.0 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain Trimer_CC PF08954.11 ORX47708.1 - 0.16 11.5 1.2 0.35 10.4 1.2 1.6 1 0 0 1 1 1 0 Trimerisation motif FliH PF02108.16 ORX47709.1 - 0.00024 21.2 9.5 1.3 9.1 0.3 3.6 3 0 0 3 3 3 3 Flagellar assembly protein FliH DUF4318 PF14201.6 ORX47709.1 - 0.0045 17.4 0.5 25 5.4 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4318) DUF3575 PF12099.8 ORX47709.1 - 0.014 14.8 10.9 0.93 8.8 0.6 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3575) Glucodextran_N PF09137.11 ORX47709.1 - 0.02 14.5 42.2 0.36 10.4 8.5 3.2 3 0 0 3 3 3 0 Glucodextranase, domain N UPA_2 PF17809.1 ORX47709.1 - 0.061 13.2 1.5 8.5 6.2 0.0 3.4 3 0 0 3 3 3 0 UPA domain Glyco_hydro_72 PF03198.14 ORX47710.1 - 4.7e-129 430.2 0.5 5.8e-129 429.9 0.5 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ORX47710.1 - 2e-18 66.8 4.4 5.1e-18 65.5 4.4 1.7 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 ORX47710.1 - 0.0016 17.9 0.1 0.041 13.3 0.1 2.4 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_2_C PF02836.17 ORX47710.1 - 0.015 14.4 0.2 0.12 11.4 0.2 2.1 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain MAD PF05557.13 ORX47711.1 - 8.3e-48 163.3 60.7 1.3e-47 162.5 60.7 1.3 1 0 0 1 1 1 1 Mitotic checkpoint protein T3SS_basalb_I PF17001.5 ORX47711.1 - 1.2 9.8 11.6 0.045 14.3 1.4 3.8 3 1 0 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI JmjC PF02373.22 ORX47712.1 - 1.3e-07 32.0 0.0 3.4e-07 30.7 0.0 1.8 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ORX47712.1 - 0.00057 19.7 0.0 0.054 13.2 0.0 2.3 2 0 0 2 2 2 1 Cupin-like domain Cupin_2 PF07883.11 ORX47712.1 - 0.022 14.5 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 Cupin domain Cupin_4 PF08007.12 ORX47712.1 - 0.095 12.1 0.0 0.24 10.8 0.0 1.7 1 0 0 1 1 1 0 Cupin superfamily protein zf-B_box PF00643.24 ORX47712.1 - 1.8 8.8 7.4 6 7.1 6.8 2.1 1 1 1 2 2 2 0 B-box zinc finger DZR PF12773.7 ORX47712.1 - 2.4 8.3 5.4 2.2 8.4 2.7 2.2 2 0 0 2 2 2 0 Double zinc ribbon C1_2 PF03107.16 ORX47712.1 - 3.2 8.1 7.7 7.4 7.0 7.7 1.7 1 0 0 1 1 1 0 C1 domain Metallophos PF00149.28 ORX47713.1 - 4.4e-20 73.1 1.7 1e-19 71.9 1.5 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ORX47713.1 - 3.8e-07 30.6 5.8 3.8e-07 30.6 5.8 2.1 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Metallophos_C PF14008.6 ORX47713.1 - 4.8e-07 30.5 1.8 8.6e-07 29.7 0.2 2.3 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos_2 PF12850.7 ORX47713.1 - 0.014 15.6 0.0 0.076 13.2 0.0 2.0 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Adaptin_N PF01602.20 ORX47714.1 - 8.2e-120 400.8 6.2 1.1e-119 400.4 6.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX47714.1 - 3.9e-14 53.0 0.9 2.2e-10 40.8 0.0 3.0 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ORX47714.1 - 1.2e-06 28.2 0.6 1.8 9.0 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ORX47714.1 - 0.00014 22.1 0.3 0.98 9.8 0.0 3.7 3 1 2 5 5 5 3 HEAT repeats AP3D1 PF06375.11 ORX47714.1 - 0.00015 22.1 0.3 0.00015 22.1 0.3 4.9 1 1 2 4 4 4 2 AP-3 complex subunit delta-1 MecA PF05389.12 ORX47714.1 - 0.42 10.2 7.5 3.3 7.3 5.0 2.5 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) DUF1682 PF07946.14 ORX47714.1 - 6.3 5.9 14.8 17 4.5 8.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) GRAM PF02893.20 ORX47715.1 - 1.8e-30 105.2 5.2 8.2e-20 70.8 0.6 3.4 3 0 0 3 3 3 3 GRAM domain Glyco_transf_28 PF03033.20 ORX47715.1 - 8.8e-28 97.1 0.0 1.6e-27 96.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 ORX47715.1 - 8.3e-11 42.3 2.9 2.4e-10 40.8 0.0 3.0 3 0 0 3 3 3 1 PH domain UDPGT PF00201.18 ORX47715.1 - 5e-09 35.5 0.0 8.8e-09 34.7 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_8 PF15409.6 ORX47715.1 - 0.00035 20.8 0.3 0.0031 17.8 0.1 2.5 2 0 0 2 2 2 1 Pleckstrin homology domain PT PF04886.12 ORX47715.1 - 0.036 13.6 2.1 0.11 12.0 2.1 1.8 1 0 0 1 1 1 0 PT repeat Vps36_ESCRT-II PF11605.8 ORX47715.1 - 0.13 12.4 0.1 0.64 10.2 0.1 2.1 2 0 0 2 2 2 0 Vacuolar protein sorting protein 36 Vps36 PH_11 PF15413.6 ORX47715.1 - 0.45 11.0 2.7 9.7 6.7 0.3 3.3 2 1 0 2 2 2 0 Pleckstrin homology domain SET PF00856.28 ORX47716.1 - 4.3e-07 30.5 0.0 4.9e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 SET domain UBA PF00627.31 ORX47717.1 - 5.2e-07 29.4 0.0 8.7e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 UBA/TS-N domain DUF3141 PF11339.8 ORX47717.1 - 0.07 11.5 0.1 0.091 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Peptidase_S26 PF10502.9 ORX47718.1 - 0.001 18.9 0.0 0.89 9.3 0.0 2.3 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 ORX47718.1 - 0.0028 17.6 0.1 0.038 14.0 0.1 2.4 1 1 0 1 1 1 1 Peptidase S24-like Sec23_trunk PF04811.15 ORX47719.1 - 6.3e-58 196.2 0.0 9.6e-58 195.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ORX47719.1 - 3.5e-20 71.7 0.0 9e-20 70.4 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ORX47719.1 - 5.3e-18 65.5 0.0 2.7e-17 63.3 0.0 2.1 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ORX47719.1 - 3.8e-14 52.4 2.0 7.9e-14 51.4 2.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX47719.1 - 5.8e-06 26.1 0.0 1.6e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ORX47719.1 - 0.12 11.8 0.1 0.29 10.6 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Myb_DNA-binding PF00249.31 ORX47720.1 - 0.00033 20.8 0.1 0.00063 19.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain BUD22 PF09073.10 ORX47720.1 - 0.81 9.0 12.7 1.1 8.5 12.7 1.1 1 0 0 1 1 1 0 BUD22 Myb_DNA-binding PF00249.31 ORX47723.1 - 0.00019 21.6 0.0 0.00027 21.1 0.0 1.2 1 0 0 1 1 1 1 Myb-like DNA-binding domain Scm3 PF10384.9 ORX47723.1 - 0.13 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 Centromere protein Scm3 Epimerase PF01370.21 ORX47724.1 - 5.6e-52 176.6 0.0 6.5e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX47724.1 - 1.7e-46 159.1 0.0 2.2e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ORX47724.1 - 1.7e-17 63.4 0.0 3.7e-16 59.0 0.0 1.9 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ORX47724.1 - 3.7e-17 62.4 0.0 3.1e-16 59.4 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX47724.1 - 3.2e-12 46.1 0.0 4.4e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ORX47724.1 - 8.3e-11 41.7 0.1 2.7e-10 40.0 0.0 2.0 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ORX47724.1 - 4.4e-08 33.2 0.0 1.3e-07 31.7 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ORX47724.1 - 3.2e-07 29.8 0.1 2.8e-06 26.7 0.1 2.1 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 ORX47724.1 - 7e-07 29.3 0.0 1.3e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ORX47724.1 - 4.7e-05 23.1 0.0 8.5e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 ORX47724.1 - 8.9e-05 22.2 0.2 0.0003 20.4 0.1 1.9 2 0 0 2 2 2 1 NmrA-like family TrkA_N PF02254.18 ORX47724.1 - 0.011 16.0 0.1 0.023 14.9 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 ORX47724.1 - 0.029 14.8 0.0 0.047 14.1 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Pkinase PF00069.25 ORX47725.1 - 1.8e-25 89.8 0.0 2.2e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47725.1 - 2.1e-11 43.6 0.0 3.4e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX47725.1 - 7.8e-08 31.5 0.0 9.9e-08 31.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DEAD PF00270.29 ORX47726.1 - 1.8e-49 167.8 0.1 3.4e-49 167.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX47726.1 - 1.6e-24 86.3 0.1 3.2e-23 82.2 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX47726.1 - 8.3e-20 70.8 0.0 2e-19 69.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX47726.1 - 1.7e-07 31.4 0.0 1.7e-07 31.4 0.0 2.8 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit GATA PF00320.27 ORX47727.1 - 4.6e-19 67.7 2.8 5.6e-19 67.5 2.8 1.1 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX47727.1 - 0.0019 17.7 1.0 0.0025 17.3 1.0 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding DZR PF12773.7 ORX47727.1 - 0.013 15.5 0.3 0.034 14.2 0.3 1.7 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ORX47727.1 - 0.019 15.1 0.4 0.025 14.7 0.4 1.2 1 0 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_2 PF13240.6 ORX47727.1 - 0.034 13.9 5.2 1.4 8.8 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ORX47727.1 - 0.054 12.9 2.0 4.1 7.0 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.6 ORX47727.1 - 0.072 13.0 1.5 0.93 9.5 1.6 2.2 1 1 1 2 2 2 0 Nudix N-terminal F-box-like PF12937.7 ORX47728.1 - 8.2e-06 25.6 2.1 2.2e-05 24.2 0.5 2.4 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX47728.1 - 0.051 13.5 0.3 0.7 9.9 0.1 3.0 3 0 0 3 3 3 0 F-box domain ERG4_ERG24 PF01222.17 ORX47730.1 - 1.3e-95 320.7 17.9 1.2e-92 310.9 17.9 2.0 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ORX47730.1 - 0.014 14.9 3.3 0.034 13.7 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1295) DMT_6 PF04342.12 ORX47730.1 - 0.08 13.2 3.4 2.1 8.6 0.0 3.2 2 1 1 3 3 3 0 Putative member of DMT superfamily (DUF486) F-box-like PF12937.7 ORX47731.1 - 2e-05 24.4 0.6 4.2e-05 23.4 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX47731.1 - 2.3e-05 24.1 0.2 7.1e-05 22.6 0.2 1.8 1 0 0 1 1 1 1 F-box domain tRNA_synthFbeta PF17759.1 ORX47732.1 - 1.4e-47 162.0 0.0 3.6e-47 160.6 0.0 1.7 2 0 0 2 2 2 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 ORX47732.1 - 5.1e-30 103.5 0.4 7.5e-29 99.8 0.1 2.3 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 ORX47732.1 - 5e-28 97.9 0.1 9e-28 97.1 0.1 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 ORX47732.1 - 1e-19 70.6 0.0 7.4e-17 61.4 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetase B5 domain DUF2740 PF10872.8 ORX47732.1 - 0.039 13.8 0.0 0.094 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2740) SH3BGR PF04908.15 ORX47733.1 - 8.6e-13 48.3 0.0 8.6e-13 48.3 0.0 3.1 3 0 0 3 3 3 1 SH3-binding, glutamic acid-rich protein Glutaredoxin PF00462.24 ORX47733.1 - 0.00062 19.9 0.0 0.053 13.7 0.0 3.2 2 0 0 2 2 2 1 Glutaredoxin DUF3450 PF11932.8 ORX47733.1 - 0.071 12.4 0.2 0.071 12.4 0.2 5.3 2 1 3 5 5 5 0 Protein of unknown function (DUF3450) KH_8 PF17903.1 ORX47735.1 - 0.00011 22.2 0.0 0.00022 21.2 0.0 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 ORX47735.1 - 0.0015 18.3 0.3 0.003 17.4 0.3 1.5 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 ORX47735.1 - 0.059 13.2 0.2 3.6 7.5 0.0 2.6 3 0 0 3 3 3 0 KH domain Mcp5_PH PF12814.7 ORX47737.1 - 1e-18 67.6 5.3 1.7e-18 66.9 0.2 2.5 2 0 0 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology Spc7 PF08317.11 ORX47737.1 - 0.0031 16.4 25.6 0.0031 16.4 25.6 2.8 3 0 0 3 3 3 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ORX47737.1 - 0.0052 16.8 1.3 0.0052 16.8 1.3 4.3 3 1 2 5 5 5 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 His_biosynth PF00977.21 ORX47738.1 - 4.4e-47 160.5 0.2 1.3e-46 159.0 0.2 1.8 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 ORX47738.1 - 7.6e-20 71.5 0.0 1.3e-19 70.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 ORX47738.1 - 6.5e-11 42.4 0.0 1.8e-10 41.0 0.0 1.7 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 ORX47738.1 - 2.5e-10 40.3 0.0 4.5e-10 39.4 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 ORX47738.1 - 0.0021 17.9 0.0 0.0044 16.8 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 IBN_N PF03810.19 ORX47739.1 - 2e-16 59.6 0.5 2.2e-14 53.1 0.0 3.4 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 ORX47739.1 - 5.9e-05 23.2 0.2 0.00045 20.3 0.0 2.7 2 1 0 2 2 2 1 Exportin 1-like protein HEAT_2 PF13646.6 ORX47739.1 - 0.0069 16.7 0.6 0.058 13.8 0.1 2.7 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 ORX47739.1 - 0.28 11.7 1.6 22 5.7 0.0 4.0 4 0 0 4 4 4 0 HEAT-like repeat FMO-like PF00743.19 ORX47740.1 - 8.3e-40 136.7 0.0 1.6e-23 82.9 0.0 3.7 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ORX47740.1 - 2.4e-20 73.0 0.0 1.2e-14 54.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX47740.1 - 1.2e-16 60.9 0.0 2e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX47740.1 - 6.4e-09 36.0 0.0 0.047 13.7 0.0 3.6 3 0 0 3 3 3 3 FAD-NAD(P)-binding DAO PF01266.24 ORX47740.1 - 1.4e-08 34.7 0.0 2.8e-07 30.5 0.0 2.4 1 1 1 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX47740.1 - 2.6e-07 30.8 0.0 2e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 ORX47740.1 - 2.9e-07 30.0 0.0 9.9e-06 24.9 0.0 2.7 2 1 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ORX47740.1 - 3e-06 26.7 0.1 0.00053 19.3 0.0 2.3 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 ORX47740.1 - 3e-05 22.9 0.1 0.00061 18.6 0.0 2.7 3 0 0 3 3 3 1 HI0933-like protein FAD_binding_3 PF01494.19 ORX47740.1 - 4e-05 23.0 0.1 7.9e-05 22.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ORX47740.1 - 0.00064 20.2 0.3 0.13 12.8 0.0 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX47740.1 - 0.00069 18.8 0.0 0.0018 17.4 0.0 1.6 2 0 0 2 2 2 1 FAD binding domain IlvN PF07991.12 ORX47740.1 - 0.0011 18.5 0.0 0.0028 17.2 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Amino_oxidase PF01593.24 ORX47740.1 - 0.0016 17.8 0.0 0.79 8.9 0.0 3.1 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 ORX47740.1 - 0.0059 15.7 0.0 0.012 14.7 0.0 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein Shikimate_DH PF01488.20 ORX47740.1 - 0.0063 16.6 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ORX47740.1 - 0.017 15.6 0.0 2.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding FAD_oxidored PF12831.7 ORX47740.1 - 0.021 14.2 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 ORX47740.1 - 0.031 13.4 0.0 0.44 9.6 0.0 2.3 2 1 0 2 2 2 0 Glucose inhibited division protein A 3HCDH_N PF02737.18 ORX47740.1 - 0.053 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ORX47740.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 ORX47740.1 - 0.063 12.6 0.0 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ORX47740.1 - 0.067 12.5 0.0 1.9 7.8 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TauD PF02668.16 ORX47741.1 - 7.1e-30 104.7 0.0 1.1e-29 104.1 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 ORX47741.1 - 0.038 13.1 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 CsiD AA_permease_2 PF13520.6 ORX47742.1 - 0.00015 20.8 8.9 0.00016 20.7 8.9 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_Tyr_perm PF03222.13 ORX47742.1 - 0.015 14.3 6.5 0.018 14.1 6.5 1.0 1 0 0 1 1 1 0 Tryptophan/tyrosine permease family AA_permease PF00324.21 ORX47742.1 - 0.2 10.2 9.8 0.23 10.0 9.8 1.0 1 0 0 1 1 1 0 Amino acid permease AA_permease_2 PF13520.6 ORX47743.1 - 3.9e-28 98.5 15.4 3.9e-28 98.5 15.4 1.4 2 0 0 2 2 2 1 Amino acid permease DUF751 PF05421.11 ORX47743.1 - 0.13 13.0 10.1 0.8 10.5 3.8 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF751) AA_permease_2 PF13520.6 ORX47744.1 - 1.2e-70 238.5 33.9 1.5e-70 238.2 33.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX47744.1 - 1.8e-22 79.6 31.7 1.8e-22 79.6 31.7 1.4 1 1 0 1 1 1 1 Amino acid permease RRM_1 PF00076.22 ORX47745.1 - 3.5e-22 78.0 1.4 1.5e-09 37.6 0.1 3.8 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX47745.1 - 3.5e-07 30.0 0.0 0.033 14.1 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif DUF4523 PF15023.6 ORX47745.1 - 0.0031 17.3 0.0 2 8.2 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF4523) RRM_7 PF16367.5 ORX47745.1 - 0.0086 16.2 0.0 4.2 7.5 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif RRM_3 PF08777.11 ORX47745.1 - 0.019 15.0 0.1 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 RNA binding motif RRM_5 PF13893.6 ORX47745.1 - 0.026 14.1 0.0 0.63 9.7 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MoaE PF02391.17 ORX47746.1 - 1.3e-37 128.5 0.1 1.5e-37 128.4 0.1 1.1 1 0 0 1 1 1 1 MoaE protein Toprim_4 PF13662.6 ORX47746.1 - 0.091 13.2 0.0 10 6.7 0.0 2.3 2 0 0 2 2 2 0 Toprim domain tRNA-synt_2 PF00152.20 ORX47747.1 - 3.6e-94 315.4 0.0 5.9e-94 314.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX47747.1 - 1.2e-08 34.8 0.0 2.9e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-like PF12869.7 ORX47747.1 - 0.00052 19.7 1.1 0.0012 18.5 1.1 1.5 1 1 0 1 1 1 1 tRNA_anti-like Ribosomal_L22 PF00237.19 ORX47747.1 - 0.0036 17.5 2.8 0.13 12.5 3.2 2.5 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e TMPIT PF07851.13 ORX47747.1 - 0.49 9.6 2.2 0.75 9.0 2.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein 5_3_exonuc PF01367.20 ORX47747.1 - 8.9 7.0 8.0 33 5.1 8.0 2.0 1 1 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold zf-C2H2 PF00096.26 ORX47748.1 - 2.7e-11 43.2 15.1 6e-06 26.4 2.2 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX47748.1 - 3.6e-09 36.6 17.0 1.4e-06 28.4 5.0 3.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX47748.1 - 2e-07 31.2 11.5 0.00043 20.9 1.2 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX47748.1 - 0.02 14.9 0.5 0.02 14.9 0.5 2.9 3 1 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.5 ORX47748.1 - 0.037 14.7 0.7 0.079 13.6 0.1 1.8 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 ORX47748.1 - 0.04 13.7 12.5 0.22 11.3 0.2 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Proteasome PF00227.26 ORX47749.1 - 3.1e-57 193.2 0.4 3.8e-57 192.8 0.4 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX47749.1 - 5.7e-14 51.5 0.0 1.3e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Homeodomain PF00046.29 ORX47750.1 - 2.2e-14 53.0 4.9 4e-14 52.2 4.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX47750.1 - 9.5e-05 22.2 1.0 0.00018 21.3 1.0 1.4 1 0 0 1 1 1 1 Homeobox KN domain HTH_32 PF13565.6 ORX47750.1 - 0.032 14.8 0.1 0.06 14.0 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF5420 PF17457.2 ORX47750.1 - 0.11 12.4 1.0 0.15 11.9 1.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5420) DUF2110 PF09883.9 ORX47750.1 - 0.2 11.2 0.1 0.27 10.8 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) F-box-like PF12937.7 ORX47751.1 - 1.6e-09 37.5 1.6 1.6e-09 37.5 1.6 2.2 2 0 0 2 2 2 1 F-box-like SKA1 PF07160.12 ORX47751.1 - 0.34 10.7 2.5 1.8 8.4 3.0 1.9 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Yip1 PF04893.17 ORX47752.1 - 1.3e-15 57.6 16.5 3.7e-15 56.0 16.5 1.7 1 1 0 1 1 1 1 Yip1 domain DUF1282 PF06930.12 ORX47752.1 - 0.075 12.8 11.6 0.11 12.3 11.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) Kelch_4 PF13418.6 ORX47753.1 - 1.6e-15 56.8 3.5 6.8e-05 22.8 0.1 4.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX47753.1 - 9.1e-08 31.9 0.1 0.009 16.0 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ORX47753.1 - 8.3e-07 29.1 4.7 0.087 13.2 0.4 5.0 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ORX47753.1 - 4.5e-05 23.2 0.4 0.72 9.9 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ORX47753.1 - 0.04 14.2 13.9 0.043 14.1 1.1 4.8 4 2 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX47753.1 - 0.19 11.3 3.8 0.73 9.5 0.3 3.4 4 1 0 4 4 4 0 Kelch motif DUF676 PF05057.14 ORX47754.1 - 0.00027 20.5 0.0 0.00047 19.7 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 ORX47754.1 - 0.0053 16.5 0.0 0.0088 15.8 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 ORX47754.1 - 0.0088 15.7 0.2 0.13 11.9 0.2 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold LCAT PF02450.15 ORX47754.1 - 0.0091 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase Palm_thioest PF02089.15 ORX47754.1 - 0.015 15.2 0.0 0.03 14.2 0.0 1.6 2 0 0 2 2 2 0 Palmitoyl protein thioesterase DUF915 PF06028.11 ORX47754.1 - 0.052 12.9 0.0 1.3 8.3 0.0 2.3 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Peptidase_S8 PF00082.22 ORX47755.1 - 1.9e-24 86.4 26.1 5.3e-19 68.6 13.1 3.5 1 1 1 2 2 2 2 Subtilase family DUF4097 PF13349.6 ORX47757.1 - 8.7e-05 22.0 0.2 0.00059 19.2 0.2 2.0 1 1 0 1 1 1 1 Putative adhesin Fil_haemagg_2 PF13332.6 ORX47757.1 - 1.3 9.2 4.2 1.4 9.0 0.4 2.7 4 0 0 4 4 4 0 Hemagglutinin repeat CorA PF01544.18 ORX47758.1 - 1.5e-43 149.2 11.0 1.5e-41 142.7 11.0 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein ATG16 PF08614.11 ORX47758.1 - 0.051 13.8 0.8 0.13 12.5 0.4 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Rad51 PF08423.11 ORX47759.1 - 2.1e-18 66.5 0.0 2.8e-18 66.1 0.0 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ORX47759.1 - 0.0032 17.1 0.3 0.011 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain Robl_LC7 PF03259.17 ORX47760.1 - 1e-05 25.2 0.0 2e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 Roadblock/LC7 domain SLM4 PF16818.5 ORX47760.1 - 0.081 12.9 0.4 2.2 8.2 0.4 2.2 1 1 0 1 1 1 0 Protein SLM4 GAGA PF09237.11 ORX47761.1 - 0.039 13.8 0.2 0.064 13.1 0.2 1.4 1 0 0 1 1 1 0 GAGA factor Myosin_head PF00063.21 ORX47762.1 - 4.9e-266 884.3 1.9 4.9e-266 884.3 1.9 2.1 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 ORX47762.1 - 1.7e-27 95.7 2.7 1.7e-27 95.7 2.7 2.9 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 ORX47762.1 - 3.7e-16 57.3 30.0 0.00016 21.1 1.0 7.4 7 0 0 7 7 7 5 IQ calmodulin-binding motif AAA_22 PF13401.6 ORX47762.1 - 0.0066 16.7 0.6 0.039 14.2 0.0 2.7 3 0 0 3 3 3 1 AAA domain Leu_zip PF15294.6 ORX47762.1 - 0.019 14.5 22.9 0.071 12.6 3.1 2.6 1 1 1 2 2 2 0 Leucine zipper AAA_16 PF13191.6 ORX47762.1 - 0.085 13.2 4.4 0.13 12.7 0.0 3.0 2 1 0 2 2 1 0 AAA ATPase domain Fib_alpha PF08702.10 ORX47762.1 - 0.18 12.0 12.9 0.13 12.4 9.6 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Csm1_N PF18504.1 ORX47762.1 - 1.8 9.0 23.0 0.45 10.9 6.5 3.7 2 1 1 3 3 3 0 Csm1 N-terminal domain Spc42p PF11544.8 ORX47762.1 - 3 7.9 12.0 0.98 9.5 3.9 2.9 2 0 0 2 2 2 0 Spindle pole body component Spc42p Fez1 PF06818.15 ORX47762.1 - 3.3 8.1 26.4 0.36 11.3 20.9 2.2 2 1 0 2 2 2 0 Fez1 bZIP_1 PF00170.21 ORX47762.1 - 5.7 7.1 14.5 1.1 9.4 2.1 3.5 3 1 0 3 3 3 0 bZIP transcription factor DUF2203 PF09969.9 ORX47762.1 - 8.7 7.1 15.0 49 4.7 7.0 3.3 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) ATG16 PF08614.11 ORX47762.1 - 8.8 6.5 28.5 7.6 6.7 4.0 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) OrfB_Zn_ribbon PF07282.11 ORX47763.1 - 0.00025 20.9 0.1 0.00045 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Cullin PF00888.22 ORX47764.1 - 9.6e-181 602.5 15.4 9.6e-181 602.5 15.4 1.5 2 0 0 2 2 2 1 Cullin family Cullin_Nedd8 PF10557.9 ORX47764.1 - 2.4e-26 91.6 3.8 9.2e-26 89.7 3.8 2.1 1 0 0 1 1 1 1 Cullin protein neddylation domain Phage_TAC_12 PF12363.8 ORX47764.1 - 0.00097 19.5 0.2 0.008 16.6 0.0 2.7 2 0 0 2 2 2 1 Phage tail assembly chaperone protein, TAC DUF3658 PF12395.8 ORX47764.1 - 0.018 14.9 1.7 0.11 12.4 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function Penicillinase_R PF03965.16 ORX47764.1 - 1.1 9.6 5.0 0.91 9.9 0.1 3.4 3 1 0 3 3 3 0 Penicillinase repressor Pkinase PF00069.25 ORX47765.1 - 8.8e-51 172.8 0.0 1.7e-34 119.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47765.1 - 5.4e-31 107.8 0.0 9e-23 80.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX47765.1 - 0.018 13.8 0.0 0.032 13.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 ORX47765.1 - 0.037 13.4 0.0 0.56 9.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like FYVE PF01363.21 ORX47766.1 - 2e-12 47.0 8.6 3.2e-12 46.4 8.6 1.3 1 0 0 1 1 1 1 FYVE zinc finger zf-HIT PF04438.16 ORX47766.1 - 0.0032 17.3 2.7 0.0032 17.3 2.7 2.3 3 0 0 3 3 3 1 HIT zinc finger zf-AN1 PF01428.16 ORX47766.1 - 0.2 11.9 11.7 0.46 10.7 11.7 1.6 1 0 0 1 1 1 0 AN1-like Zinc finger Pkinase PF00069.25 ORX47767.1 - 2.6e-70 236.8 0.0 4.8e-70 235.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47767.1 - 5.1e-42 143.9 0.0 8.9e-42 143.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX47767.1 - 1.9e-05 24.1 0.0 6.6e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX47767.1 - 0.0024 16.7 0.3 0.0078 15.0 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ORX47767.1 - 0.038 13.0 0.0 0.072 12.1 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 YL1 PF05764.13 ORX47767.1 - 0.39 10.8 14.3 0.011 15.9 7.2 1.9 2 0 0 2 2 2 0 YL1 nuclear protein DUF2457 PF10446.9 ORX47767.1 - 0.6 9.2 23.6 1.2 8.2 23.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sigma70_ner PF04546.13 ORX47767.1 - 1.1 9.1 11.3 0.068 13.0 4.5 2.5 2 0 0 2 2 2 0 Sigma-70, non-essential region HTH_28 PF13518.6 ORX47768.1 - 0.00023 21.2 0.2 0.00084 19.4 0.2 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX47768.1 - 0.011 15.5 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain LZ_Tnp_IS481 PF13011.6 ORX47768.1 - 0.034 14.7 0.0 0.07 13.7 0.0 1.6 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 HTH_IclR PF09339.10 ORX47768.1 - 0.044 13.6 0.2 0.082 12.7 0.2 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_29 PF13551.6 ORX47768.1 - 0.045 13.8 0.9 0.1 12.6 0.1 2.0 2 0 0 2 2 2 0 Winged helix-turn helix MarR_2 PF12802.7 ORX47768.1 - 0.089 12.7 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 MarR family HTH_1 PF00126.27 ORX47768.1 - 0.089 12.8 0.2 0.18 11.8 0.2 1.5 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family Septin PF00735.18 ORX47770.1 - 9.7e-112 372.8 0.9 1.4e-111 372.3 0.9 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX47770.1 - 1.5e-07 31.4 0.0 4.4e-07 30.0 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX47770.1 - 6.8e-07 29.3 3.7 1.1e-05 25.4 0.1 3.1 3 1 1 4 4 4 1 RsgA GTPase GTP_EFTU PF00009.27 ORX47770.1 - 2.7e-06 27.1 5.0 2.1e-05 24.1 0.1 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_15 PF13175.6 ORX47770.1 - 1.6e-05 24.8 0.0 3.9e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX47770.1 - 0.00017 21.9 1.3 0.00078 19.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain Roc PF08477.13 ORX47770.1 - 0.00068 19.8 1.2 0.0013 18.9 0.1 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX47770.1 - 0.00096 18.8 0.2 0.00096 18.8 0.2 2.4 2 2 0 2 2 2 1 Ras family AAA_24 PF13479.6 ORX47770.1 - 0.0011 18.7 0.4 0.0022 17.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AIG1 PF04548.16 ORX47770.1 - 0.0035 16.7 0.0 0.01 15.2 0.0 1.8 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 ORX47770.1 - 0.0062 15.6 0.0 0.013 14.6 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 ORX47770.1 - 0.0079 16.6 0.4 0.018 15.5 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 ORX47770.1 - 0.012 16.1 0.9 0.063 13.8 0.0 2.3 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 ORX47770.1 - 0.017 14.7 0.1 0.032 13.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ORX47770.1 - 0.017 14.8 0.2 0.043 13.5 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain FtsK_SpoIIIE PF01580.18 ORX47770.1 - 0.018 14.4 1.0 0.03 13.7 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 ORX47770.1 - 0.023 15.1 0.1 0.084 13.3 0.1 2.0 1 1 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 ORX47770.1 - 0.032 14.4 0.0 0.095 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ORX47770.1 - 0.034 13.9 0.4 0.93 9.2 0.2 2.7 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 ORX47770.1 - 0.045 12.8 0.1 0.11 11.5 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Exonuc_VII_L PF02601.15 ORX47770.1 - 0.08 12.5 3.1 0.11 12.0 3.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit NACHT PF05729.12 ORX47770.1 - 0.092 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_25 PF13481.6 ORX47770.1 - 0.11 12.0 0.5 0.37 10.3 0.0 2.0 2 1 1 3 3 3 0 AAA domain AAA PF00004.29 ORX47770.1 - 0.14 12.5 0.3 2.1 8.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Mit_ribos_Mrp51 PF11709.8 ORX47770.1 - 0.5 9.9 5.6 0.96 9.0 5.6 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit Dynamin_N PF00350.23 ORX47770.1 - 8.2 6.5 9.5 6 6.9 0.3 3.4 3 1 1 4 4 4 0 Dynamin family SpoU_methylase PF00588.19 ORX47771.1 - 3.5e-33 114.7 0.0 1e-32 113.3 0.0 1.7 2 0 0 2 2 2 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 ORX47771.1 - 1.1e-12 48.0 0.1 1.9e-12 47.2 0.1 1.4 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding Ribosomal_S30 PF04758.14 ORX47772.1 - 2.5e-28 98.0 9.3 2.9e-28 97.8 9.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Ribosomal_S3Ae PF01015.18 ORX47773.1 - 6.1e-74 248.0 4.7 7.1e-74 247.8 4.7 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Med3 PF11593.8 ORX47773.1 - 0.005 16.1 0.1 0.0081 15.4 0.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Caudo_TAP PF02413.17 ORX47773.1 - 0.056 13.6 1.6 3.1 7.9 1.0 2.3 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK TipAS PF07739.13 ORX47773.1 - 0.083 13.4 0.2 0.84 10.2 0.0 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SUI1 PF01253.22 ORX47773.1 - 0.09 13.3 0.9 2 9.0 0.1 2.4 2 0 0 2 2 2 0 Translation initiation factor SUI1 EMP24_GP25L PF01105.24 ORX47774.1 - 2.7e-46 157.8 0.1 3e-46 157.7 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Sec2p PF06428.11 ORX47774.1 - 0.013 15.4 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p Rh5 PF18515.1 ORX47774.1 - 0.039 13.2 0.7 0.047 13.0 0.7 1.1 1 0 0 1 1 1 0 Rh5 coiled-coil domain DUF1408 PF07193.11 ORX47774.1 - 0.051 13.7 0.1 0.094 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1408) Proteasome PF00227.26 ORX47775.1 - 2.2e-61 206.7 0.1 2.6e-61 206.4 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX47775.1 - 1.1e-13 50.6 0.0 1.9e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Zn_clus PF00172.18 ORX47776.1 - 5.5e-12 45.6 8.3 6.6e-12 45.3 8.3 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX47777.1 - 5.6e-42 143.6 0.2 1.2e-41 142.5 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Cyclin_N PF00134.23 ORX47778.1 - 8.2e-17 61.1 5.6 1.8e-16 60.1 5.6 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 ORX47778.1 - 4.2e-07 29.9 0.8 0.0012 18.9 0.2 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat Ecl1 PF12855.7 ORX47781.1 - 0.63 11.2 8.5 0.71 11.0 8.5 1.1 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins SLATT_1 PF18181.1 ORX47782.1 - 0.02 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 DUF1129 PF06570.11 ORX47782.1 - 0.033 13.7 0.2 0.047 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) MRP-L28 PF09812.9 ORX47783.1 - 4.9e-12 46.3 1.2 6e-12 46.0 1.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 RelA_SpoT PF04607.17 ORX47783.1 - 0.033 14.5 0.0 0.041 14.2 0.0 1.2 1 0 0 1 1 1 0 Region found in RelA / SpoT proteins G_path_suppress PF15991.5 ORX47783.1 - 0.14 12.3 6.0 0.16 12.1 5.4 1.3 1 1 0 1 1 1 0 G-protein pathway suppressor Glyco_tran_28_C PF04101.16 ORX47784.1 - 5.7e-25 88.2 0.0 6.8e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 ORX47784.1 - 0.036 14.1 0.0 0.25 11.3 0.0 1.8 1 1 1 2 2 2 0 Glycosyltransferase Family 4 THOC2_N PF16134.5 ORX47785.1 - 7.6e-17 61.2 1.0 1.2e-14 53.9 0.3 2.2 2 0 0 2 2 2 2 THO complex subunit 2 N-terminus Ndr PF03096.14 ORX47785.1 - 0.096 11.4 0.1 9.5 4.8 0.1 2.2 2 0 0 2 2 2 0 Ndr family WD40 PF00400.32 ORX47786.1 - 7.3e-18 64.6 10.7 1.4e-05 25.8 0.3 6.4 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX47786.1 - 3.4e-08 33.7 0.1 0.038 14.3 0.0 4.0 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ORX47786.1 - 0.002 16.9 0.7 1.9 7.1 0.0 3.7 3 1 0 4 4 4 1 Nup133 N terminal like Nup160 PF11715.8 ORX47786.1 - 0.0025 16.5 0.7 0.81 8.3 0.0 3.0 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX47786.1 - 0.01 14.9 0.3 1.4 7.8 0.0 2.3 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ORX47786.1 - 0.031 13.6 0.5 0.25 10.6 0.0 2.6 2 2 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal MMS1_N PF10433.9 ORX47787.1 - 2.6e-70 237.4 1.5 5.6e-70 236.3 0.4 2.1 3 0 0 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX47787.1 - 1e-57 195.9 0.0 5.3e-56 190.3 0.0 3.1 3 0 0 3 3 3 1 CPSF A subunit region DUF4152 PF13680.6 ORX47787.1 - 0.11 11.9 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4152) Glycos_transf_1 PF00534.20 ORX47788.1 - 1.1e-25 90.1 0.0 1.5e-25 89.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 ALG11_N PF15924.5 ORX47788.1 - 4.3e-20 72.7 1.9 6.1e-20 72.2 1.9 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glyco_trans_1_4 PF13692.6 ORX47788.1 - 1e-09 38.9 0.0 1.5e-09 38.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ORX47788.1 - 0.012 16.0 0.0 0.03 14.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 ALG11_N PF15924.5 ORX47789.1 - 1.3e-31 110.3 0.0 1.8e-31 109.9 0.0 1.1 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Polysacc_deac_1 PF01522.21 ORX47790.1 - 1.2e-32 112.4 0.0 1.8e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ORX47790.1 - 0.00011 21.5 0.0 0.00024 20.4 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 57 UPF0180 PF03698.13 ORX47790.1 - 0.23 11.7 0.6 19 5.5 0.0 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0180) Pkinase PF00069.25 ORX47791.1 - 7.8e-99 330.3 0.0 3.7e-69 233.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47791.1 - 1.3e-51 175.4 0.0 5.6e-35 120.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX47791.1 - 8.1e-11 41.8 1.5 1.9e-09 37.3 0.0 3.1 3 1 0 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 ORX47791.1 - 4.5e-07 29.0 0.0 0.004 16.0 0.0 2.1 2 0 0 2 2 2 2 Fungal protein kinase Kdo PF06293.14 ORX47791.1 - 1.3e-06 27.9 1.2 0.0011 18.3 0.4 2.3 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX47791.1 - 9.2e-06 25.8 1.2 0.22 11.4 0.1 3.3 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX47791.1 - 0.00094 18.2 1.6 0.0063 15.5 0.9 2.3 2 1 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 ORX47791.1 - 0.026 14.2 0.4 9.9 5.7 0.1 3.1 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ORX47791.1 - 0.062 12.9 0.5 8.9 5.9 0.0 3.0 2 1 0 2 2 2 0 RIO1 family CP2 PF04516.15 ORX47793.1 - 7.1e-47 159.6 0.3 1e-46 159.1 0.3 1.2 1 0 0 1 1 1 1 CP2 transcription factor DUF4833 PF16117.5 ORX47793.1 - 0.1 12.6 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4833) p450 PF00067.22 ORX47795.1 - 1.2e-71 241.9 0.1 1.4e-71 241.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 UCH PF00443.29 ORX47796.1 - 1.6e-22 80.3 0.8 2.9e-22 79.4 0.8 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ORX47796.1 - 1.3e-15 57.5 12.8 1.3e-15 57.5 12.8 3.1 4 0 0 4 4 4 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ORX47796.1 - 1.2e-11 44.8 11.5 1.2e-11 44.8 11.5 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Prim_Zn_Ribbon PF08273.12 ORX47796.1 - 0.076 13.3 1.4 0.28 11.5 0.0 2.4 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Iso_dh PF00180.20 ORX47797.1 - 2.1e-98 329.7 0.0 5.3e-98 328.4 0.0 1.5 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase TAF4 PF05236.14 ORX47798.1 - 6.9e-14 52.2 14.6 2.6e-13 50.4 14.6 1.9 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family FAD_binding_1 PF00667.20 ORX47799.1 - 2e-62 210.7 0.0 3.3e-62 209.9 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain POR_N PF01855.19 ORX47799.1 - 1.3e-24 87.3 1.2 2e-24 86.6 1.2 1.3 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg NAD_binding_1 PF00175.21 ORX47799.1 - 1.4e-11 45.0 0.0 3.7e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 ORX47799.1 - 0.0033 17.7 0.0 0.0086 16.4 0.0 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Orn_Arg_deC_N PF02784.16 ORX47799.1 - 0.05 13.0 0.3 0.13 11.6 0.1 1.8 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain FAD_binding_6 PF00970.24 ORX47799.1 - 0.066 13.6 0.0 2.3 8.6 0.0 2.6 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain OrfB_Zn_ribbon PF07282.11 ORX47800.1 - 0.024 14.5 0.4 0.084 12.8 0.4 2.0 1 0 0 1 1 1 0 Putative transposase DNA-binding domain CryBP1 PF07029.11 ORX47800.1 - 0.12 12.5 0.1 0.39 10.8 0.0 1.9 2 0 0 2 2 2 0 CryBP1 protein HTH_32 PF13565.6 ORX47802.1 - 3.5e-07 30.8 0.0 4.2e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX47802.1 - 3.4e-05 23.8 0.0 8.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 ORX47802.1 - 4.9e-05 23.4 0.1 7.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX47802.1 - 0.00093 18.9 0.0 0.0016 18.2 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX47802.1 - 0.051 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Chromo PF00385.24 ORX47947.1 - 2.3e-11 43.4 1.7 4.1e-11 42.6 1.7 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RhoGEF PF00621.20 ORX47948.1 - 4.9e-28 98.6 0.8 1.1e-27 97.5 0.8 1.6 1 0 0 1 1 1 1 RhoGEF domain Ribonuclease_T2 PF00445.18 ORX47950.1 - 1.1e-37 130.0 2.5 1.5e-37 129.6 2.5 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Vac14_Fig4_bd PF11916.8 ORX47951.1 - 1.1e-80 269.5 8.1 1.1e-80 269.5 8.1 2.0 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 ORX47951.1 - 2.1e-48 162.9 0.0 1.4e-40 137.8 0.0 4.4 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ORX47951.1 - 1.4e-13 49.8 1.2 0.016 15.4 0.0 7.1 7 0 0 7 7 7 2 HEAT repeat Arm PF00514.23 ORX47951.1 - 2.3e-08 33.8 0.0 3.2 7.9 0.0 5.9 5 0 0 5 5 5 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX47951.1 - 2.7e-08 34.1 3.1 2.6 8.6 0.0 6.5 6 0 0 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 ORX47951.1 - 2.6e-07 30.9 4.9 3.8 8.0 0.0 6.0 6 1 0 7 7 7 3 HEAT repeats MMS19_C PF12460.8 ORX47951.1 - 2.6e-06 26.8 1.7 0.097 11.8 0.0 4.4 4 1 0 4 4 4 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 ORX47951.1 - 4.7e-06 26.7 1.3 1.7 8.6 0.1 5.0 5 0 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX47951.1 - 2.7e-05 23.8 0.0 0.86 9.1 0.0 3.9 3 1 1 4 4 4 2 CLASP N terminal DUF3385 PF11865.8 ORX47951.1 - 0.0011 18.9 0.5 1.7 8.5 0.0 4.0 4 0 0 4 4 4 1 Domain of unknown function (DUF3385) RasGEF_N_2 PF14663.6 ORX47951.1 - 0.5 10.8 9.4 8 6.9 0.2 4.3 6 0 0 6 6 6 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain CRC_subunit PF08624.10 ORX47952.1 - 2.8e-42 144.3 0.0 5e-42 143.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit PHD PF00628.29 ORX47952.1 - 2e-20 72.4 49.8 7.3e-09 35.4 15.5 4.3 3 1 1 4 4 4 3 PHD-finger zf-HIT PF04438.16 ORX47952.1 - 0.02 14.8 2.6 0.02 14.8 2.6 5.4 7 0 0 7 7 7 0 HIT zinc finger Requiem_N PF14051.6 ORX47952.1 - 0.084 13.1 0.3 0.21 11.8 0.3 1.7 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. PHD_2 PF13831.6 ORX47952.1 - 0.1 12.2 23.8 1 9.0 3.3 4.2 3 0 0 3 3 3 0 PHD-finger C1_1 PF00130.22 ORX47952.1 - 0.2 11.5 39.3 0.06 13.2 3.8 4.5 3 1 1 4 4 4 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Sod_Cu PF00080.20 ORX47954.1 - 1.8e-31 109.2 3.0 1.9e-31 109.1 1.1 1.8 2 0 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) HMA PF00403.26 ORX47954.1 - 5.5e-11 42.8 0.0 1e-10 41.9 0.0 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain Gaa1 PF04114.14 ORX47956.1 - 1.7e-122 410.0 4.1 2.1e-122 409.7 4.1 1.1 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component DEAD PF00270.29 ORX47957.1 - 5.6e-35 120.7 0.1 9.7e-35 119.9 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX47957.1 - 2.9e-28 98.4 0.9 3.6e-26 91.7 0.2 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX47957.1 - 1.3e-07 31.8 0.0 2.2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ORX47957.1 - 0.0007 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DAO PF01266.24 ORX47959.1 - 1.1e-32 114.1 0.0 1.2e-32 113.9 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ORX47959.1 - 0.0054 15.9 0.3 0.011 14.8 0.3 1.5 2 0 0 2 2 2 1 FAD binding domain Glu_dehyd_C PF16912.5 ORX47959.1 - 0.011 15.3 0.0 3 7.3 0.0 2.1 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus DEFB136 PF17333.2 ORX47959.1 - 0.038 14.0 0.1 0.098 12.6 0.1 1.7 1 0 0 1 1 1 0 Beta defensin 136 NAD_binding_8 PF13450.6 ORX47959.1 - 0.11 12.7 2.6 0.26 11.5 1.5 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX47959.1 - 0.21 10.8 3.0 0.2 10.9 1.7 1.6 2 0 0 2 2 2 0 FAD binding domain Ribosomal_S10 PF00338.22 ORX47960.1 - 6.4e-29 100.1 0.5 9.6e-29 99.5 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e PUF PF00806.19 ORX47961.1 - 4.1e-18 64.0 0.1 0.00063 19.3 0.0 7.1 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat Basic PF01586.16 ORX47961.1 - 0.029 15.5 0.1 0.029 15.5 0.1 2.2 2 0 0 2 2 2 0 Myogenic Basic domain DUF445 PF04286.12 ORX47961.1 - 0.051 13.4 0.2 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF445) Glyco_hydro_15 PF00723.21 ORX47962.1 - 9.9e-58 196.0 0.0 1.3e-55 189.0 0.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 15 ANAPC4_WD40 PF12894.7 ORX47963.1 - 1.1e-05 25.7 0.0 0.048 13.9 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX47963.1 - 0.0012 19.6 0.0 0.063 14.2 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat CNH PF00780.22 ORX47963.1 - 0.0035 17.0 0.0 2.7 7.5 0.0 2.7 3 0 0 3 3 3 2 CNH domain IRK_N PF08466.10 ORX47963.1 - 0.065 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal Ge1_WD40 PF16529.5 ORX47963.1 - 0.074 12.0 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 ORX47963.1 - 0.081 12.0 0.0 7.9 5.4 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region ocr PF08684.10 ORX47965.1 - 0.0076 16.7 0.1 0.0078 16.6 0.1 1.1 1 0 0 1 1 1 1 DNA mimic ocr Syja_N PF02383.18 ORX47966.1 - 5.6e-77 259.2 0.0 8.6e-77 258.6 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 ORX47966.1 - 1.4e-09 37.9 0.1 4.4e-09 36.2 0.0 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family HA PF03457.14 ORX47967.1 - 0.22 11.9 0.1 3 8.3 0.1 2.4 1 1 0 1 1 1 0 Helicase associated domain EI24 PF07264.11 ORX47968.1 - 1.7e-23 83.8 13.0 2.4e-23 83.3 13.0 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Mpv17_PMP22 PF04117.12 ORX47969.1 - 1.2e-23 83.1 0.2 1.9e-23 82.4 0.2 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family Mem_trans PF03547.18 ORX47970.1 - 0.17 10.2 0.1 0.21 10.0 0.1 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF1492 PF07374.11 ORX47971.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) DUF775 PF05603.12 ORX47972.1 - 1.6e-60 204.1 0.0 1.8e-60 203.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) Abhydrolase_3 PF07859.13 ORX47973.1 - 6.2e-42 143.9 0.0 7.6e-42 143.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX47973.1 - 0.0001 21.3 0.1 0.00014 20.8 0.1 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase ACP_syn_III_C PF08541.10 ORX47973.1 - 0.017 15.2 0.0 0.034 14.3 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal PC-Esterase PF13839.6 ORX47973.1 - 0.14 11.9 0.0 0.2 11.4 0.0 1.2 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p COesterase PF00135.28 ORX47973.1 - 0.17 10.8 0.1 5.1 5.8 0.1 2.0 2 0 0 2 2 2 0 Carboxylesterase family LIDHydrolase PF10230.9 ORX47973.1 - 0.2 11.2 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 ORX47974.1 - 2.8e-45 154.8 0.1 3.7e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX47974.1 - 6.5e-05 21.9 0.1 8.4e-05 21.6 0.1 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX47974.1 - 0.0017 17.8 0.1 0.022 14.2 0.1 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_M28 PF04389.17 ORX47975.1 - 1.9e-35 122.4 0.6 3e-35 121.7 0.2 1.5 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX47975.1 - 1.5e-08 34.6 0.2 3.2e-08 33.5 0.2 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4251 PF14059.6 ORX47975.1 - 0.022 14.7 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4251) RPA43_OB PF17875.1 ORX47976.1 - 2.6e-24 86.2 2.0 6.3e-24 85.0 0.3 2.0 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 ORX47976.1 - 9.1e-11 42.0 0.0 1.9e-09 37.8 0.0 2.3 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 FAM176 PF14851.6 ORX47976.1 - 0.37 10.4 2.6 0.69 9.6 0.3 2.0 2 0 0 2 2 2 0 FAM176 family OrfB_Zn_ribbon PF07282.11 ORX47978.1 - 0.00062 19.6 7.1 0.95 9.4 7.1 2.7 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Mpv17_PMP22 PF04117.12 ORX47981.1 - 1.2e-13 51.1 2.8 1.4e-13 50.8 2.8 1.1 1 0 0 1 1 1 1 Mpv17 / PMP22 family Sensor_TM1 PF13755.6 ORX47981.1 - 0.096 12.4 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain ATP_bind_3 PF01171.20 ORX47982.1 - 5.3e-18 65.4 0.0 8e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 ORX47982.1 - 2.5e-17 62.1 3.6 2.5e-17 62.1 3.6 3.2 4 0 0 4 4 4 1 Zinc-ribbon tRNA_Me_trans PF03054.16 ORX47982.1 - 0.01 14.7 0.0 0.017 13.9 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase DUF4428 PF14471.6 ORX47982.1 - 0.55 10.2 5.2 0.12 12.3 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) TrbE PF11100.8 ORX47983.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TrbE RPA43_OB PF17875.1 ORX47984.1 - 0.00033 21.3 0.5 0.00044 20.9 0.5 1.2 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I HGTP_anticodon2 PF12745.7 ORX47984.1 - 0.018 14.5 0.4 0.02 14.4 0.4 1.0 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs PIF1 PF05970.14 ORX47985.1 - 2.7e-14 53.2 0.2 3.2e-14 52.9 0.2 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ORX47985.1 - 4.2e-07 29.9 0.0 6.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX47985.1 - 8.4e-06 25.4 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region PhoH PF02562.16 ORX47985.1 - 4.8e-05 22.9 0.0 6.5e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.6 ORX47985.1 - 0.00034 21.0 0.1 0.00052 20.4 0.1 1.3 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ORX47985.1 - 0.0012 17.9 0.0 0.0014 17.7 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein Mg_chelatase PF01078.21 ORX47985.1 - 0.0034 16.8 0.0 0.005 16.2 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 ORX47985.1 - 0.0045 16.3 0.1 0.0071 15.6 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ORX47985.1 - 0.0045 16.9 0.1 0.008 16.1 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_25 PF13481.6 ORX47985.1 - 0.0061 16.2 0.0 0.0099 15.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ORX47985.1 - 0.0094 16.3 0.0 0.02 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ResIII PF04851.15 ORX47985.1 - 0.0099 15.9 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX47985.1 - 0.016 15.5 0.1 0.038 14.3 0.1 1.6 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX47985.1 - 0.02 15.3 0.1 0.04 14.3 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ORX47985.1 - 0.027 15.0 0.0 0.055 14.0 0.0 1.5 1 0 0 1 1 1 0 ABC transporter Parvo_NS1 PF01057.17 ORX47985.1 - 0.031 13.4 0.0 0.04 13.0 0.0 1.3 1 1 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_29 PF13555.6 ORX47985.1 - 0.09 12.5 0.0 0.18 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.9 ORX47985.1 - 0.092 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain UvrD-helicase PF00580.21 ORX47985.1 - 0.094 12.2 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Microtub_bd PF16796.5 ORX47985.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Microtubule binding AAA_5 PF07728.14 ORX47985.1 - 0.16 11.9 0.1 0.47 10.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 ORX47985.1 - 0.18 11.1 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 KaiC NTPase_1 PF03266.15 ORX47985.1 - 0.19 11.6 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 NTPase cobW PF02492.19 ORX47985.1 - 0.2 11.2 0.1 0.29 10.7 0.1 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PIF1 PF05970.14 ORX47986.1 - 3e-06 26.7 0.7 0.00033 19.9 0.4 2.6 1 1 1 2 2 2 1 PIF1-like helicase SH3_13 PF18335.1 ORX47986.1 - 0.034 14.0 0.0 0.075 12.9 0.0 1.7 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain AAA_30 PF13604.6 ORX47986.1 - 0.095 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF5409 PF17421.2 ORX47987.1 - 0.032 15.0 0.5 0.048 14.4 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5409) Fungal_trans PF04082.18 ORX47989.1 - 1.8e-09 37.0 0.0 4.5e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX47989.1 - 3.2e-09 36.8 10.0 8.5e-09 35.4 10.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain REV PF00424.18 ORX47989.1 - 0.018 15.0 0.0 0.046 13.7 0.0 1.6 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) AA_kinase PF00696.28 ORX47990.1 - 1.5e-40 139.3 0.3 2.4e-40 138.7 0.3 1.2 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 ORX47990.1 - 3e-08 33.5 0.2 8.2e-08 32.1 0.2 1.8 1 0 0 1 1 1 1 PUA domain Glyco_hydro_72 PF03198.14 ORX47991.1 - 3.9e-119 397.6 5.9 1.1e-118 396.0 5.9 1.7 1 1 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 ORX47991.1 - 2e-12 47.6 1.4 5.1e-12 46.3 1.4 1.8 1 0 0 1 1 1 1 X8 domain Pkinase PF00069.25 ORX47992.1 - 1.1e-57 195.4 0.0 1.4e-57 195.1 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX47992.1 - 2e-29 102.7 0.0 2.4e-29 102.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX47992.1 - 3.2e-08 33.2 0.0 5.7e-08 32.4 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX47992.1 - 0.00058 19.3 0.7 0.00092 18.6 0.7 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ORX47992.1 - 0.0018 17.9 0.3 0.0025 17.4 0.3 1.2 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL APH PF01636.23 ORX47992.1 - 0.016 15.1 0.1 0.056 13.4 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX47992.1 - 0.034 12.9 0.1 0.055 12.2 0.1 1.3 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 ORX47992.1 - 0.12 12.0 0.5 0.18 11.4 0.5 1.3 1 1 0 1 1 1 0 RIO1 family Cast PF10174.9 ORX47994.1 - 0.00053 18.4 4.7 0.00064 18.1 4.7 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone CdvA PF18822.1 ORX47994.1 - 0.028 14.3 3.5 0.38 10.6 3.5 2.0 1 1 0 1 1 1 0 CdvA-like coiled-coil domain PfUIS3 PF11567.8 ORX47994.1 - 0.032 14.6 1.0 0.045 14.1 1.0 1.3 1 0 0 1 1 1 0 Plasmodium falciparum UIS3 membrane protein Ntox28 PF15605.6 ORX47994.1 - 0.033 14.4 2.2 0.046 13.9 2.2 1.2 1 0 0 1 1 1 0 Bacterial toxin 28 Cytochrom_B562 PF07361.11 ORX47994.1 - 0.041 14.5 2.8 0.054 14.1 2.8 1.2 1 0 0 1 1 1 0 Cytochrome b562 DUF4407 PF14362.6 ORX47994.1 - 0.061 12.7 3.3 0.069 12.5 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 ORX47994.1 - 0.14 12.6 7.8 0.21 12.0 7.8 1.4 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region IZUMO PF15005.6 ORX47994.1 - 0.51 10.9 3.4 0.72 10.4 3.4 1.2 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated HTH_ABP1_N PF18107.1 ORX47994.1 - 0.55 10.0 9.0 0.28 10.9 1.3 2.5 1 1 2 3 3 3 0 Fission yeast centromere protein N-terminal domain CDC24_OB1 PF17246.2 ORX47994.1 - 0.85 9.7 0.0 0.85 9.7 0.0 2.4 1 1 1 2 2 2 0 Cell division control protein 24, OB domain 1 CCDC-167 PF15188.6 ORX47994.1 - 1.6 9.1 5.7 1.3 9.4 3.9 1.7 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Atg14 PF10186.9 ORX47994.1 - 8.5 5.3 11.7 11 5.0 11.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-K PF11802.8 ORX47995.1 - 0.12 11.9 0.1 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 Centromere-associated protein K Peptidase_M22 PF00814.25 ORX47997.1 - 0.11 12.2 0.1 0.28 10.8 0.0 1.6 1 1 1 2 2 2 0 Glycoprotease family UPF0052 PF01933.18 ORX47998.1 - 2.1e-49 168.3 0.0 3e-49 167.8 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 PPR_2 PF13041.6 ORX47999.1 - 1.2e-56 188.7 26.3 5.4e-10 39.3 0.2 16.1 12 3 7 19 19 19 10 PPR repeat family PPR_3 PF13812.6 ORX47999.1 - 2e-41 139.9 8.8 9.3e-10 38.4 0.2 11.5 11 1 2 13 13 13 8 Pentatricopeptide repeat domain PPR PF01535.20 ORX47999.1 - 3.6e-33 111.5 25.9 0.00092 19.3 0.4 15.4 17 0 0 17 17 15 6 PPR repeat PPR_1 PF12854.7 ORX47999.1 - 2.3e-26 91.2 1.6 0.029 14.1 0.0 12.5 12 0 0 12 12 12 6 PPR repeat PPR_long PF17177.4 ORX47999.1 - 2.8e-25 88.9 30.9 5.5e-09 35.7 2.2 8.5 2 2 6 9 9 9 5 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 ORX47999.1 - 1.8e-06 28.4 3.5 0.019 15.4 0.0 5.9 5 1 1 6 6 6 1 Mitochondrial ribonuclease P subunit (RPM2) TPR_19 PF14559.6 ORX47999.1 - 0.00071 20.0 9.6 6.2 7.4 0.0 7.6 6 2 3 9 9 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX47999.1 - 0.0041 17.7 0.4 2.1 9.1 0.0 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX47999.1 - 0.0049 17.6 6.1 35 5.6 0.0 7.3 6 2 1 8 8 6 0 Tetratricopeptide repeat COX5A PF02284.16 ORX47999.1 - 0.012 15.6 2.2 0.44 10.6 0.0 4.3 3 1 1 4 4 4 0 Cytochrome c oxidase subunit Va DUF3368 PF11848.8 ORX47999.1 - 0.079 12.8 0.1 2.5 8.0 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3368) Methyltransf_25 PF13649.6 ORX47999.1 - 0.099 13.4 0.1 1.4 9.7 0.0 3.2 2 0 0 2 2 1 0 Methyltransferase domain Ribonuc_red_lgN PF00317.21 ORX47999.1 - 0.12 12.3 1.1 7 6.7 0.0 3.9 3 0 0 3 3 3 0 Ribonucleotide reductase, all-alpha domain TPR_8 PF13181.6 ORX47999.1 - 0.22 11.8 3.4 12 6.4 0.1 4.6 4 0 0 4 4 3 0 Tetratricopeptide repeat Stork_head PF10264.9 ORX47999.1 - 0.26 11.5 1.8 6.4 7.0 0.0 3.7 3 1 0 3 3 3 0 Winged helix Storkhead-box1 domain TPR_12 PF13424.6 ORX47999.1 - 0.27 11.5 3.4 7.8 6.9 0.1 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat MNE1 PF13762.6 ORX47999.1 - 0.28 11.2 6.1 8.8 6.3 0.6 4.2 3 1 2 5 5 5 0 Mitochondrial splicing apparatus component TPR_10 PF13374.6 ORX47999.1 - 1.3 9.0 5.4 21 5.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat MitMem_reg PF13012.6 ORX48000.1 - 2.4e-39 134.2 0.4 4.3e-39 133.4 0.4 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ORX48000.1 - 9.4e-34 115.9 0.0 1.5e-33 115.2 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Coatomer_WDAD PF04053.14 ORX48002.1 - 2.1e-139 465.4 0.0 3.6e-139 464.6 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 ORX48002.1 - 1.7e-127 425.6 0.0 2.1e-127 425.2 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 ORX48002.1 - 6.8e-43 143.8 19.0 2.3e-08 34.5 0.1 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48002.1 - 1.2e-10 41.6 0.2 0.0041 17.4 0.0 6.2 4 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX48002.1 - 0.79 8.3 8.6 4 6.0 0.1 3.9 2 1 2 4 4 4 0 Nucleoporin Nup120/160 WD40 PF00400.32 ORX48003.1 - 7.1e-08 33.0 8.0 0.019 15.8 0.2 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat FYVE PF01363.21 ORX48004.1 - 0.00011 22.2 8.2 0.0052 16.9 8.2 2.4 1 1 0 1 1 1 1 FYVE zinc finger SLATT_5 PF18160.1 ORX48004.1 - 0.061 12.6 0.7 0.098 12.0 0.7 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 TEA PF01285.18 ORX48005.1 - 6.7e-31 106.2 0.0 1.4e-30 105.2 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain YBD PF17725.1 ORX48005.1 - 5.4e-07 29.7 0.3 9.3e-07 28.9 0.3 1.3 1 0 0 1 1 1 1 YAP binding domain V-SNARE_C PF12352.8 ORX48006.1 - 5.6e-18 65.0 3.4 5.6e-18 65.0 3.4 2.5 2 2 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 ORX48006.1 - 1.2e-14 54.4 1.0 1.2e-14 54.4 1.0 2.3 3 0 0 3 3 3 1 Vesicle transport v-SNARE protein N-terminus Sec20 PF03908.13 ORX48006.1 - 0.00098 19.0 1.1 0.0039 17.1 0.2 2.4 2 1 0 2 2 2 1 Sec20 Fusion_gly PF00523.18 ORX48006.1 - 0.0018 16.6 4.9 0.012 13.9 0.1 2.5 3 0 0 3 3 3 2 Fusion glycoprotein F0 PEARLI-4 PF05278.12 ORX48006.1 - 0.012 15.2 0.9 0.014 15.0 0.1 1.5 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Halo_GVPC PF05465.13 ORX48006.1 - 0.079 13.2 0.8 0.15 12.4 0.8 1.5 1 0 0 1 1 1 0 Halobacterial gas vesicle protein C (GVPC) repeat hNIFK_binding PF12196.8 ORX48006.1 - 0.15 11.6 2.3 0.47 10.0 0.0 2.6 3 0 0 3 3 3 0 FHA Ki67 binding domain of hNIFK Leucyl-specific PF14795.6 ORX48006.1 - 0.17 12.0 2.4 0.3 11.2 0.3 2.1 2 0 0 2 2 2 0 Leucine-tRNA synthetase-specific domain DHR10 PF18595.1 ORX48006.1 - 5.2 7.2 9.3 5.8 7.0 1.3 2.9 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain HSA PF07529.13 ORX48007.1 - 2.3e-16 59.8 3.8 2.3e-16 59.8 3.8 3.5 3 0 0 3 3 3 1 HSA Myb_DNA-bind_6 PF13921.6 ORX48007.1 - 6.9e-07 29.4 0.8 2.4e-06 27.7 0.2 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX48007.1 - 0.0045 17.2 0.2 0.01 16.0 0.2 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PhoLip_ATPase_C PF16212.5 ORX48008.1 - 1.8e-52 178.6 20.9 1.8e-52 178.6 20.9 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX48008.1 - 1.3e-15 56.8 5.9 3.5e-15 55.4 5.9 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ORX48008.1 - 1e-13 51.2 0.0 1e-13 51.2 0.0 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX48008.1 - 5.5e-13 49.7 1.9 1.7e-06 28.5 2.1 3.7 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX48008.1 - 1.3e-09 38.0 0.1 4.1e-08 33.2 0.0 2.8 2 1 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX48008.1 - 0.00029 20.7 0.0 0.00084 19.1 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Amidohydro_1 PF01979.20 ORX48009.1 - 3.9e-67 227.0 2.5 5.6e-67 226.5 2.5 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ORX48009.1 - 3.5e-56 188.7 1.7 3.5e-56 188.7 1.7 1.7 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 ORX48009.1 - 2.2e-41 139.8 0.0 4.4e-41 138.9 0.0 1.5 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 ORX48009.1 - 2.8e-19 69.3 0.3 1e-18 67.5 0.1 2.1 2 0 0 2 2 2 1 Urease, gamma subunit Amidohydro_3 PF07969.11 ORX48009.1 - 9.4e-06 25.4 0.5 0.00013 21.5 0.1 2.4 3 0 0 3 3 3 1 Amidohydrolase family cobW PF02492.19 ORX48010.1 - 2.3e-33 115.3 0.0 3.4e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ORX48010.1 - 0.00026 20.1 0.2 0.085 11.8 0.1 2.1 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 ORX48010.1 - 0.00037 20.5 0.0 0.0018 18.3 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ORX48010.1 - 0.02 15.5 0.0 0.033 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ORX48010.1 - 0.026 14.5 0.0 0.032 14.2 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_5 PF07728.14 ORX48010.1 - 0.046 13.7 0.0 0.088 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ORX48010.1 - 0.071 13.6 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 ORX48010.1 - 0.083 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 ORX48010.1 - 0.11 11.7 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_16 PF13191.6 ORX48010.1 - 0.11 12.9 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SelP_N PF04592.14 ORX48010.1 - 0.51 9.7 11.0 0.73 9.2 11.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region adh_short PF00106.25 ORX48011.1 - 4.4e-41 140.5 0.2 5.8e-41 140.1 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX48011.1 - 3e-22 79.3 0.0 4.3e-22 78.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX48011.1 - 2.2e-09 37.5 0.0 3.3e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX48011.1 - 0.00023 20.4 0.1 0.00032 19.9 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ORX48011.1 - 0.0027 17.6 0.1 0.0037 17.2 0.1 1.4 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ORX48011.1 - 0.0094 15.4 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX48011.1 - 0.053 13.0 0.0 0.077 12.4 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 ORX48011.1 - 0.12 12.4 0.3 0.35 10.9 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Big_3_5 PF16640.5 ORX48012.1 - 0.26 11.5 1.8 7.4 6.8 0.1 2.8 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) SWIM PF04434.17 ORX48014.1 - 0.0049 16.5 0.2 0.0071 16.0 0.2 1.2 1 0 0 1 1 1 1 SWIM zinc finger SDH_sah PF01972.16 ORX48016.1 - 0.062 12.3 0.8 0.067 12.2 0.8 1.1 1 0 0 1 1 1 0 Serine dehydrogenase proteinase TrbM PF07424.11 ORX48019.1 - 0.0063 16.5 0.3 0.0085 16.0 0.3 1.1 1 0 0 1 1 1 1 TrbM Fungal_trans PF04082.18 ORX48021.1 - 7.8e-27 94.0 0.1 1.7e-26 92.9 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX48021.1 - 2.6e-10 40.3 12.0 6.2e-10 39.0 12.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AA_kinase PF00696.28 ORX48022.1 - 3.2e-41 141.5 0.1 5.3e-41 140.8 0.1 1.3 1 0 0 1 1 1 1 Amino acid kinase family ACT PF01842.25 ORX48022.1 - 1.2e-10 40.9 0.8 9.3e-05 22.1 0.1 3.0 3 0 0 3 3 3 2 ACT domain ACT_7 PF13840.6 ORX48022.1 - 1.8e-10 40.5 4.5 1.3e-07 31.3 1.1 2.7 2 0 0 2 2 2 2 ACT domain Cyclin_N PF00134.23 ORX48023.1 - 8.8e-16 57.8 1.5 8.2e-15 54.7 0.7 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 ORX48023.1 - 4.4e-07 30.2 0.1 2.4e-06 27.9 0.1 2.2 1 1 0 1 1 1 1 Cyclin C-terminal domain TFIIB PF00382.19 ORX48023.1 - 1.9e-05 24.6 0.7 9e-05 22.5 0.1 2.4 3 0 0 3 3 3 1 Transcription factor TFIIB repeat RB_B PF01857.20 ORX48023.1 - 0.0074 16.3 3.1 2.6 8.1 0.0 2.6 3 0 0 3 3 3 2 Retinoblastoma-associated protein B domain DMP12 PF16779.5 ORX48023.1 - 0.035 14.1 0.4 0.24 11.4 0.1 2.2 2 0 0 2 2 2 0 DNA-mimic protein Cyclin_C PF02984.19 ORX48023.1 - 0.04 14.0 0.3 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Cyclin, C-terminal domain VASt PF16016.5 ORX48024.1 - 1.1e-36 126.6 1.2 1.1e-36 126.6 1.2 2.3 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ORX48024.1 - 3.8e-23 81.5 0.0 7.2e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 GRAM domain CAP_N PF01213.19 ORX48024.1 - 5.6 6.3 13.7 4.8 6.6 0.5 2.5 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Pkinase PF00069.25 ORX48025.1 - 1.7e-51 175.1 0.0 2.2e-51 174.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48025.1 - 3.2e-30 105.3 0.0 3.8e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX48025.1 - 2e-05 24.1 0.1 3.2e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX48025.1 - 0.0027 17.1 0.0 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX48025.1 - 0.0065 16.4 0.3 0.0065 16.4 0.3 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family ID PF18543.1 ORX48025.1 - 0.092 12.8 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Intracellular delivery domain RNA_Me_trans PF04252.13 ORX48026.1 - 2.3e-58 197.1 0.0 2.8e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase Peptidase_M50B PF13398.6 ORX48027.1 - 3.7e-53 180.1 18.1 5e-53 179.7 18.1 1.1 1 0 0 1 1 1 1 Peptidase M50B-like MFS_MOT1 PF16983.5 ORX48027.1 - 3.5 8.1 17.7 0.19 12.1 4.6 3.7 3 2 1 4 4 4 0 Molybdate transporter of MFS superfamily Ndc1_Nup PF09531.10 ORX48027.1 - 4.2 6.0 9.9 5.9 5.5 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TIM PF00121.18 ORX48028.1 - 4.6e-89 298.0 0.0 5.2e-89 297.8 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Creatinase_N PF01321.18 ORX48028.1 - 0.08 13.6 0.0 0.13 12.9 0.0 1.5 1 1 0 1 1 1 0 Creatinase/Prolidase N-terminal domain zf-C2H2 PF00096.26 ORX48029.1 - 7.2e-09 35.6 7.1 0.00055 20.3 0.9 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX48029.1 - 2.5e-07 30.8 2.2 2.5e-07 30.8 2.2 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX48029.1 - 0.00099 19.8 6.4 0.35 11.8 0.7 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX48029.1 - 0.0021 18.7 1.1 0.046 14.3 0.1 2.3 2 0 0 2 2 2 1 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 ORX48029.1 - 0.018 15.4 1.3 0.05 13.9 1.0 1.8 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX48029.1 - 0.065 13.3 4.5 0.19 11.7 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX48029.1 - 0.14 12.3 0.4 0.29 11.3 0.3 1.6 1 1 0 1 1 1 0 Aberrant zinc-finger ADH_N PF08240.12 ORX48030.1 - 5.1e-25 87.5 2.5 1.4e-24 86.1 2.5 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX48030.1 - 3.3e-18 65.9 0.1 5.9e-18 65.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ORX48030.1 - 0.0012 18.4 0.1 0.0027 17.2 0.1 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ORX48030.1 - 0.018 16.1 0.0 0.034 15.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Tim17 PF02466.19 ORX48031.1 - 6.1e-31 107.1 8.3 7.7e-31 106.8 8.3 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_3_3 PF16083.5 ORX48031.1 - 0.03 14.4 8.9 0.044 13.9 0.7 2.9 2 1 1 3 3 3 0 LydA holin phage, holin superfamily III DAO PF01266.24 ORX48032.1 - 1.5e-55 189.2 0.0 1.8e-55 189.0 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX48032.1 - 1.9e-06 27.3 0.7 0.00024 20.4 0.3 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 ORX48032.1 - 3.7e-06 27.1 0.1 8.1e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX48032.1 - 4.9e-06 26.0 0.9 0.063 12.5 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Sacchrp_dh_NADP PF03435.18 ORX48032.1 - 7.1e-06 26.3 0.5 2.4e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 ORX48032.1 - 1.4e-05 25.1 0.1 0.074 13.0 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ORX48032.1 - 0.0006 19.0 0.1 0.00096 18.3 0.1 1.4 1 1 0 1 1 1 1 FAD binding domain GIDA PF01134.22 ORX48032.1 - 0.00075 18.7 0.2 0.055 12.5 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A ApbA PF02558.16 ORX48032.1 - 0.002 17.8 0.1 0.0035 17.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 ORX48032.1 - 0.0023 16.9 0.5 0.012 14.5 0.3 1.9 2 0 0 2 2 2 1 Tryptophan halogenase TrkA_N PF02254.18 ORX48032.1 - 0.0038 17.5 0.0 0.0072 16.6 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain GMC_oxred_N PF00732.19 ORX48032.1 - 0.029 13.7 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase FAD_binding_3 PF01494.19 ORX48032.1 - 0.033 13.4 0.3 0.23 10.7 0.1 1.9 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 ORX48032.1 - 0.059 13.9 0.1 0.13 12.8 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ORX48032.1 - 0.19 11.8 0.1 0.33 11.0 0.1 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SR-25 PF10500.9 ORX48033.1 - 7.4 6.1 6.1 13 5.3 6.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DAO PF01266.24 ORX48035.1 - 3.9e-52 178.0 0.0 4.9e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX48035.1 - 0.00012 21.5 0.1 0.15 11.3 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX48035.1 - 0.00015 21.9 0.1 0.00032 20.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX48035.1 - 0.0005 19.4 0.2 0.06 12.6 0.1 2.2 2 0 0 2 2 2 2 Thi4 family Sacchrp_dh_NADP PF03435.18 ORX48035.1 - 0.001 19.3 0.3 0.0036 17.6 0.1 2.0 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 ORX48035.1 - 0.001 19.1 0.0 0.1 12.6 0.0 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding GIDA PF01134.22 ORX48035.1 - 0.023 13.8 0.3 0.073 12.1 0.0 1.8 2 0 0 2 2 2 0 Glucose inhibited division protein A LEF-9 PF05094.12 ORX48035.1 - 0.11 11.0 0.3 0.57 8.7 0.0 1.9 2 0 0 2 2 2 0 Late expression factor 9 (LEF-9) zf-RING_2 PF13639.6 ORX48038.1 - 1e-11 44.9 8.4 1.8e-11 44.2 8.4 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX48038.1 - 1.6e-10 40.6 4.4 2.9e-10 39.8 4.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX48038.1 - 1.2e-09 37.8 3.2 2.2e-09 37.0 3.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX48038.1 - 3.4e-09 36.3 2.2 7.2e-09 35.2 2.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ORX48038.1 - 7.1e-08 32.6 4.9 1.8e-07 31.3 4.9 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX48038.1 - 3.7e-07 30.0 2.5 6.3e-07 29.3 0.7 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX48038.1 - 1.1e-06 28.4 2.7 2e-06 27.6 2.7 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX48038.1 - 4e-06 26.6 3.6 8e-06 25.6 3.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX48038.1 - 9.6e-05 22.2 5.5 0.00016 21.5 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 ORX48038.1 - 0.00029 20.8 0.0 0.00051 20.0 0.0 1.4 1 0 0 1 1 1 1 PA domain zf-ANAPC11 PF12861.7 ORX48038.1 - 0.0065 16.5 4.7 0.0065 16.5 4.7 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX48038.1 - 0.035 13.7 5.1 0.067 12.8 5.1 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ORX48038.1 - 0.037 14.2 5.8 0.04 14.1 4.2 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 ORX48038.1 - 0.074 13.4 3.2 0.18 12.1 3.2 1.7 1 0 0 1 1 1 0 RING-like domain RINGv PF12906.7 ORX48038.1 - 0.089 12.9 3.8 0.18 11.9 3.3 1.8 1 1 0 1 1 1 0 RING-variant domain PHD PF00628.29 ORX48038.1 - 0.18 11.7 4.0 0.32 10.9 4.0 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 ORX48038.1 - 0.19 11.5 7.7 1.3 8.8 5.6 2.3 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain FANCL_C PF11793.8 ORX48038.1 - 1.3 9.2 6.6 15 5.9 6.6 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_1 PF14446.6 ORX48038.1 - 2.6 8.0 7.8 2.4 8.2 3.0 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 An_peroxidase PF03098.15 ORX48039.1 - 8.8e-40 136.8 0.7 9.7e-29 100.3 0.5 4.1 1 1 1 2 2 2 2 Animal haem peroxidase zf-C3HC4_2 PF13923.6 ORX48040.1 - 1e-08 34.8 7.9 5.1e-08 32.6 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX48040.1 - 2.2e-08 34.1 5.5 3.3e-07 30.3 2.6 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ORX48040.1 - 2.8e-08 33.5 4.5 1e-06 28.5 5.7 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX48040.1 - 5.1e-07 29.4 3.3 7.9e-05 22.4 1.1 2.2 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX48040.1 - 1e-06 29.0 5.4 0.00016 21.9 2.6 2.3 2 0 0 2 2 2 2 Ring finger domain zf-RING_UBOX PF13445.6 ORX48040.1 - 3.5e-06 26.9 7.3 2.8e-05 24.1 2.5 2.5 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX48040.1 - 3.3e-05 23.8 4.8 8.4e-05 22.4 4.8 1.7 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX48040.1 - 0.0012 18.6 7.3 3.2 7.7 0.0 3.2 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ORX48040.1 - 0.0029 17.4 3.7 0.01 15.6 3.7 1.9 1 1 1 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_6 PF14835.6 ORX48040.1 - 0.0081 16.0 4.5 0.038 13.9 1.9 2.3 1 1 1 2 2 2 1 zf-RING of BARD1-type protein Zn_Tnp_IS91 PF14319.6 ORX48040.1 - 0.015 15.3 0.7 0.037 14.1 0.4 1.8 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_10 PF16685.5 ORX48040.1 - 0.024 14.8 1.6 0.024 14.8 1.6 1.8 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-C3HC4_5 PF17121.5 ORX48040.1 - 0.056 13.3 2.1 0.056 13.3 2.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 ORX48040.1 - 1.6 8.6 6.8 4.4 7.1 3.8 2.5 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger zf-RING_11 PF17123.5 ORX48040.1 - 2.4 8.0 10.8 6.7 6.6 3.6 2.8 3 0 0 3 3 3 0 RING-like zinc finger zf-NADH-PPase PF09297.11 ORX48040.1 - 6.5 6.5 11.9 0.15 11.7 1.8 2.5 3 0 0 3 3 2 0 NADH pyrophosphatase zinc ribbon domain rve_3 PF13683.6 ORX48041.1 - 0.14 11.9 0.1 3.5 7.5 0.0 2.9 2 0 0 2 2 2 0 Integrase core domain Tropomyosin_1 PF12718.7 ORX48042.1 - 0.017 15.3 7.8 0.022 14.9 7.8 1.1 1 0 0 1 1 1 0 Tropomyosin like SMK-1 PF04802.15 ORX48044.1 - 4e-13 49.6 6.7 4e-13 49.6 6.7 2.3 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 HEAT PF02985.22 ORX48044.1 - 0.062 13.6 0.1 1.4 9.4 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat Urb2 PF10441.9 ORX48044.1 - 1 9.2 3.7 1.1 9.1 0.2 2.6 3 1 0 4 4 4 0 Urb2/Npa2 family DUF2462 PF09495.10 ORX48045.1 - 0.34 11.7 2.3 22 5.8 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2462) ACT_4 PF13291.6 ORX48045.1 - 0.6 10.7 5.3 0.21 12.2 0.8 2.5 3 0 0 3 3 3 0 ACT domain SRP54_N PF02881.19 ORX48045.1 - 1.2 9.4 9.4 9.5 6.5 0.4 3.4 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain FHA PF00498.26 ORX48046.1 - 1.3e-14 54.3 0.2 2.5e-14 53.4 0.2 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ORX48046.1 - 1.8e-11 43.5 5.0 1.8e-11 43.5 5.0 2.2 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX48046.1 - 6.9e-09 35.9 7.4 1.5e-08 34.8 7.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ORX48046.1 - 2e-05 24.5 6.3 3.8e-05 23.6 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX48046.1 - 2.2e-05 24.2 8.3 4.9e-05 23.1 8.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX48046.1 - 6.8e-05 22.7 7.8 0.00014 21.7 7.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX48046.1 - 0.00026 21.2 6.0 0.00058 20.1 6.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ORX48046.1 - 0.00085 19.1 5.6 0.0016 18.3 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 ORX48046.1 - 0.0055 16.6 3.8 0.01 15.7 3.8 1.5 1 0 0 1 1 1 1 PHD-finger Yop-YscD_cpl PF16697.5 ORX48046.1 - 0.0056 17.0 0.0 0.014 15.7 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-RING_UBOX PF13445.6 ORX48046.1 - 0.012 15.7 5.6 0.012 15.7 5.6 2.0 2 1 0 2 2 2 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 ORX48046.1 - 0.06 13.4 1.6 0.11 12.5 1.6 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger BRX PF08381.11 ORX48046.1 - 0.1 12.0 0.4 0.33 10.4 0.0 2.0 2 0 0 2 2 2 0 Transcription factor regulating root and shoot growth via Pin3 Prok-RING_4 PF14447.6 ORX48046.1 - 0.58 10.1 5.6 1.3 9.0 5.6 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 HD PF01966.22 ORX48047.1 - 8.9e-05 22.7 0.6 0.00022 21.4 0.6 1.7 1 0 0 1 1 1 1 HD domain Arrestin_N PF00339.29 ORX48048.1 - 3.7e-10 40.0 0.0 1.6e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX48048.1 - 0.00014 22.3 0.1 0.00022 21.7 0.1 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain TMEM171 PF15471.6 ORX48048.1 - 1.9 7.4 4.3 3.4 6.6 4.3 1.3 1 0 0 1 1 1 0 Transmembrane protein family 171 tRNA-synt_1d PF00750.19 ORX48049.1 - 1.8e-104 349.4 5.9 3.1e-104 348.7 5.9 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ORX48049.1 - 6.3e-24 84.4 0.1 1.9e-23 82.9 0.0 1.9 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 ORX48049.1 - 2.8e-08 34.2 0.0 7.5e-08 32.9 0.0 1.8 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain GST_C_2 PF13410.6 ORX48049.1 - 0.067 13.2 0.1 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Alpha_GJ PF03229.13 ORX48049.1 - 5.5 7.6 6.2 16 6.1 5.9 1.9 1 1 0 1 1 1 0 Alphavirus glycoprotein J CDC45 PF02724.14 ORX48050.1 - 1 7.5 6.9 1.2 7.4 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RhoGAP PF00620.27 ORX48051.1 - 4.3e-48 163.0 0.1 1.2e-47 161.5 0.1 1.8 1 0 0 1 1 1 1 RhoGAP domain C1_1 PF00130.22 ORX48051.1 - 3e-07 30.2 10.0 6.1e-07 29.2 10.0 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Zf_RING PF16744.5 ORX48051.1 - 0.0057 16.7 2.5 0.017 15.2 2.5 1.7 1 0 0 1 1 1 1 KIAA1045 RING finger TMF_TATA_bd PF12325.8 ORX48051.1 - 0.63 10.3 12.6 0.065 13.5 4.7 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Adeno_PV PF03910.13 ORX48051.1 - 1 8.0 4.0 1.6 7.3 4.0 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV SseC PF04888.12 ORX48051.1 - 3.8 7.0 7.9 25 4.4 5.9 2.2 1 1 1 2 2 2 0 Secretion system effector C (SseC) like family APG6_N PF17675.1 ORX48051.1 - 4.3 7.9 15.7 55 4.3 15.8 2.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Lyase_1 PF00206.20 ORX48052.1 - 8e-23 81.3 0.0 1.2e-22 80.7 0.0 1.2 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ORX48052.1 - 1.2e-17 64.1 0.0 4.3e-17 62.4 0.0 2.0 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 ORX48052.1 - 0.17 11.6 0.3 0.34 10.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) ExoD PF06055.12 ORX48052.1 - 0.19 11.1 0.1 0.31 10.4 0.1 1.3 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD DEAD PF00270.29 ORX48053.1 - 9.9e-40 136.2 1.0 2.3e-39 134.9 1.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX48053.1 - 2.3e-25 89.1 0.2 6.3e-24 84.5 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX48053.1 - 2.2e-08 34.3 0.0 7.7e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX48053.1 - 0.00048 20.4 0.3 0.0055 17.0 0.2 2.7 1 1 1 2 2 2 1 AAA domain SNF2_N PF00176.23 ORX48053.1 - 0.035 12.8 0.2 0.067 11.9 0.1 1.3 1 1 0 1 1 1 0 SNF2 family N-terminal domain Helicase_C_2 PF13307.6 ORX48053.1 - 0.042 14.0 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 Helicase C-terminal domain Alpha-E PF04168.12 ORX48053.1 - 0.066 13.0 0.5 0.37 10.5 0.1 2.3 3 0 0 3 3 3 0 A predicted alpha-helical domain with a conserved ER motif. FAD_binding_3 PF01494.19 ORX48056.1 - 1.2e-65 222.1 0.0 1.5e-65 221.8 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX48056.1 - 0.00041 19.7 0.0 0.86 8.8 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX48056.1 - 0.0038 17.4 0.0 0.01 16.0 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SE PF08491.10 ORX48056.1 - 0.0058 15.7 0.0 0.015 14.3 0.0 1.7 1 1 0 1 1 1 1 Squalene epoxidase Pyr_redox PF00070.27 ORX48056.1 - 0.012 16.1 0.0 0.33 11.6 0.1 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Phe_hydrox_dim PF07976.12 ORX48056.1 - 0.02 14.9 0.0 0.039 14.0 0.0 1.6 1 0 0 1 1 1 0 Phenol hydroxylase, C-terminal dimerisation domain TPD PF14811.6 ORX48056.1 - 0.043 13.7 0.0 0.079 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function TPD sequence-motif Pyr_redox_3 PF13738.6 ORX48056.1 - 0.048 12.9 0.0 0.13 11.5 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX48056.1 - 0.066 11.9 0.1 0.43 9.2 0.0 2.0 2 0 0 2 2 2 0 HI0933-like protein DAO PF01266.24 ORX48056.1 - 0.19 11.3 0.3 1.3 8.6 0.4 2.1 1 1 1 2 2 2 0 FAD dependent oxidoreductase Glyco_hydro_17 PF00332.18 ORX48058.1 - 1.7e-12 47.6 0.3 7e-07 29.1 0.1 2.1 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 SRP9-21 PF05486.12 ORX48059.1 - 1.6e-08 34.8 4.1 1.7e-07 31.5 0.6 2.6 2 1 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Pilin_GH PF16734.5 ORX48059.1 - 0.049 14.0 0.1 0.058 13.7 0.1 1.3 1 1 0 1 1 1 0 Type IV pilin-like G and H, putative gpW PF02831.15 ORX48059.1 - 0.066 13.1 0.1 0.14 12.1 0.1 1.5 1 0 0 1 1 1 0 gpW Ribosomal_S21e PF01249.18 ORX48060.1 - 2.3e-39 133.3 0.0 2.6e-39 133.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Lectin_leg-like PF03388.13 ORX48061.1 - 6.8e-70 235.0 0.1 8.1e-70 234.7 0.1 1.0 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 ORX48061.1 - 1.4e-11 44.8 0.3 1.9e-11 44.4 0.3 1.1 1 0 0 1 1 1 1 Bacterial lectin Lectin_legB PF00139.19 ORX48061.1 - 4.7e-06 26.3 0.0 0.0033 17.0 0.1 2.2 2 0 0 2 2 2 2 Legume lectin domain Siva PF05458.12 ORX48062.1 - 2.7e-09 37.0 15.3 3.1e-09 36.8 15.3 1.1 1 0 0 1 1 1 1 Cd27 binding protein (Siva) zf-C3HC4_3 PF13920.6 ORX48062.1 - 0.05 13.5 2.7 0.05 13.5 2.7 3.4 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-4CXXC_R1 PF10497.9 ORX48062.1 - 2.1 8.6 20.6 1.4 9.1 2.1 2.9 1 1 1 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 IBR PF01485.21 ORX48062.1 - 3.8 7.8 21.8 0.95 9.7 10.2 2.7 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DNA_pol_B PF00136.21 ORX48063.1 - 1.3e-150 502.2 1.0 1.9e-150 501.6 1.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX48063.1 - 6.3e-84 282.0 0.0 2.6e-82 276.7 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ORX48063.1 - 6.4e-17 61.8 6.1 1.3e-16 60.8 6.1 1.5 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 ORX48063.1 - 0.00041 19.3 0.8 0.0031 16.5 0.0 2.4 3 0 0 3 3 3 1 DNA polymerase type B, organellar and viral RNase_H_2 PF13482.6 ORX48063.1 - 0.013 15.5 0.4 0.068 13.2 0.4 2.2 1 1 0 1 1 1 0 RNase_H superfamily DNA_pol_B_exo2 PF10108.9 ORX48063.1 - 0.032 13.9 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB C1_1 PF00130.22 ORX48063.1 - 0.42 10.5 6.4 1.7 8.6 6.4 2.0 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 ORX48063.1 - 5 7.2 6.0 18 5.5 6.0 1.8 1 1 0 1 1 1 0 Double zinc ribbon Auto_anti-p27 PF06677.12 ORX48063.1 - 5.7 7.2 5.0 1.8 8.8 1.3 2.1 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF1453 PF07301.11 ORX48064.1 - 0.09 12.8 0.0 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1453) SAC3_GANP PF03399.16 ORX48065.1 - 1.4e-26 93.6 4.6 8e-25 87.8 4.6 2.0 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ORX48065.1 - 1.5e-06 28.2 0.2 1.2e-05 25.3 0.1 2.1 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family QueC PF06508.13 ORX48065.1 - 0.1 12.0 0.0 0.38 10.2 0.0 1.8 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC OrfB_Zn_ribbon PF07282.11 ORX48066.1 - 3.9e-08 33.1 0.3 1.1e-07 31.6 0.3 1.8 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX48066.1 - 0.0077 16.0 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease EcoRII, N-terminal Asp PF00026.23 ORX48197.1 - 2.4e-07 30.5 0.0 2.4e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease LSM PF01423.22 ORX48197.1 - 0.0056 16.3 0.0 0.0074 16.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF3425 PF11905.8 ORX48198.1 - 9.8e-16 57.9 0.1 3.4e-15 56.1 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ORX48198.1 - 6.4e-08 32.6 7.3 1.5e-07 31.4 7.3 1.6 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX48198.1 - 0.038 14.1 12.8 0.085 13.0 12.8 1.6 1 0 0 1 1 1 0 Basic region leucine zipper SHE3 PF17078.5 ORX48198.1 - 0.68 9.6 7.0 0.062 13.0 2.3 1.6 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 ORX48198.1 - 2.3 8.8 8.7 1.4 9.5 4.6 2.3 2 0 0 2 2 2 0 bZIP Maf transcription factor Cu-oxidase PF00394.22 ORX48199.1 - 1e-35 123.2 2.6 3.5e-35 121.5 0.1 2.3 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX48199.1 - 1.7e-31 108.7 3.5 2.5e-31 108.1 1.6 2.4 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX48199.1 - 5.7e-14 52.0 21.3 3.5e-12 46.2 5.4 4.8 3 2 0 3 3 3 2 Multicopper oxidase ubiquitin PF00240.23 ORX48200.1 - 3.9e-27 93.8 0.0 4.4e-27 93.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX48200.1 - 2.7e-14 52.8 0.0 2.9e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ORX48200.1 - 4.7e-05 23.2 0.0 5.6e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 ORX48200.1 - 8.2e-05 23.0 0.0 0.00014 22.3 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX48200.1 - 0.039 14.0 0.2 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX48200.1 - 0.084 13.0 0.0 0.25 11.5 0.0 1.7 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like FAD_binding_2 PF00890.24 ORX48201.1 - 1.6e-125 419.5 4.8 2.2e-125 419.1 4.8 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 ORX48201.1 - 1.5e-44 151.1 1.0 2.3e-44 150.4 1.0 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 ORX48201.1 - 3.2e-06 26.6 1.0 0.00075 18.8 0.1 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX48201.1 - 1.8e-05 24.0 1.9 0.014 14.5 2.7 2.5 2 0 0 2 2 2 2 Glucose inhibited division protein A Thi4 PF01946.17 ORX48201.1 - 2.9e-05 23.4 0.5 0.018 14.3 0.1 2.5 2 0 0 2 2 2 2 Thi4 family Lycopene_cycl PF05834.12 ORX48201.1 - 0.0014 17.8 0.2 0.035 13.1 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ORX48201.1 - 0.0028 17.0 1.1 0.0044 16.3 0.3 1.7 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 ORX48201.1 - 0.0067 16.0 0.6 0.013 15.1 0.6 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX48201.1 - 0.036 12.8 2.0 0.38 9.4 0.7 3.0 4 0 0 4 4 4 0 HI0933-like protein Pyr_redox_3 PF13738.6 ORX48201.1 - 1.5 8.0 3.7 2.4 7.4 1.3 2.3 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Apt1 PF10351.9 ORX48202.1 - 1.4e-115 386.9 0.4 1.4e-115 386.9 0.4 2.7 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 ORX48202.1 - 8.9e-97 324.9 14.8 1.4e-96 324.3 14.8 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 ORX48202.1 - 2.8e-33 115.2 0.0 7.2e-33 113.9 0.0 1.8 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 ORX48202.1 - 7e-33 113.8 0.0 1.8e-31 109.2 0.0 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 ORX48202.1 - 5.7e-19 68.7 1.5 4.4e-18 65.9 0.2 3.4 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain SET PF00856.28 ORX48203.1 - 1.7e-08 35.0 0.0 8.7e-08 32.7 0.0 2.2 2 1 0 2 2 2 1 SET domain Ppx-GppA PF02541.16 ORX48204.1 - 3.2e-41 141.6 0.0 4.5e-41 141.2 0.0 1.1 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DUF3402 PF11882.8 ORX48207.1 - 2.1e-85 287.6 11.7 9.5e-47 160.2 0.7 3.4 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 ORX48207.1 - 4.9e-31 108.0 0.4 1.3e-30 106.6 0.4 1.7 1 1 0 1 1 1 1 N1221-like protein Sec23_trunk PF04811.15 ORX48208.1 - 3.1e-63 213.6 0.0 4.6e-63 213.0 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ORX48208.1 - 3.1e-24 84.7 0.7 7.3e-24 83.6 0.7 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ORX48208.1 - 8.2e-18 64.9 0.0 1.5e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ORX48208.1 - 2e-15 56.6 5.2 4.1e-15 55.5 5.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX48208.1 - 1.4e-06 28.1 0.0 6.1e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 Gelsolin repeat RBP_receptor PF14752.6 ORX48209.1 - 1.3e-18 67.0 4.7 1.4e-18 66.8 3.3 1.7 1 1 0 1 1 1 1 Retinol binding protein receptor UPRTase PF14681.6 ORX48210.1 - 2.6e-66 223.0 0.0 3e-66 222.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DUF5083 PF16890.5 ORX48210.1 - 0.16 11.7 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) GTP_CH_N PF12471.8 ORX48211.1 - 5e-90 300.4 0.0 7e-90 300.0 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 ORX48211.1 - 1.9e-14 53.6 0.0 3e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II PLA2_B PF01735.18 ORX48212.1 - 3.2e-34 118.2 0.0 6.3e-20 71.0 0.2 2.1 2 0 0 2 2 2 2 Lysophospholipase catalytic domain Thiolase_N PF00108.23 ORX48214.1 - 3.9e-79 265.7 6.4 4.9e-78 262.1 3.8 2.0 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX48214.1 - 7.3e-46 154.8 0.5 1.5e-45 153.8 0.5 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain POP1 PF06978.11 ORX48215.1 - 2.2e-27 96.4 14.7 9e-15 55.2 7.6 2.4 1 1 1 2 2 2 2 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 ORX48215.1 - 4.1e-26 91.1 0.5 1.6e-25 89.2 0.5 2.1 1 0 0 1 1 1 1 POPLD (NUC188) domain GCV_T PF01571.21 ORX48215.1 - 0.00022 20.7 0.0 0.67 9.3 0.0 2.3 2 0 0 2 2 2 2 Aminomethyltransferase folate-binding domain zf-C2H2 PF00096.26 ORX48216.1 - 6.7e-11 42.0 9.5 4.5e-05 23.7 3.5 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX48216.1 - 3.4e-08 33.6 8.8 0.00097 19.8 2.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX48216.1 - 4.2e-07 30.1 19.5 2.8e-05 24.3 0.5 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 ORX48216.1 - 0.00023 20.9 6.0 0.027 14.2 0.3 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 ORX48216.1 - 0.00057 20.1 2.8 0.28 11.5 0.1 2.2 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX48216.1 - 0.0023 17.9 11.8 0.012 15.6 1.4 2.9 2 1 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX48216.1 - 0.0035 17.7 0.7 0.0035 17.7 0.7 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 ORX48216.1 - 0.036 14.2 4.7 3.7 7.7 0.3 3.0 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 ORX48216.1 - 0.15 12.4 0.2 0.15 12.4 0.2 2.3 2 1 1 3 3 3 0 Zinc-finger double-stranded RNA-binding Abhydrolase_2 PF02230.16 ORX48217.1 - 7e-69 231.9 0.0 7.9e-69 231.8 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ORX48217.1 - 1.8e-12 47.1 0.4 9.2e-06 25.1 0.0 3.0 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ORX48217.1 - 1.1e-09 38.1 0.5 6.6e-06 25.7 0.0 2.4 2 1 1 3 3 3 2 Prolyl oligopeptidase family DLH PF01738.18 ORX48217.1 - 2.3e-08 33.9 0.0 3.2e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 ORX48217.1 - 2.3e-06 27.4 0.1 0.0051 16.5 0.2 2.7 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ORX48217.1 - 9.4e-06 25.6 0.0 0.1 12.4 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 ORX48217.1 - 1e-05 25.3 0.0 4.3e-05 23.3 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 ORX48217.1 - 1.5e-05 25.8 0.0 1.8e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.10 ORX48217.1 - 0.00054 20.0 0.0 0.00089 19.3 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein DUF2920 PF11144.8 ORX48217.1 - 0.0035 16.6 0.0 0.93 8.6 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2920) Esterase PF00756.20 ORX48217.1 - 0.0071 16.0 0.0 0.011 15.4 0.0 1.4 1 0 0 1 1 1 1 Putative esterase DUF829 PF05705.14 ORX48217.1 - 0.0075 16.2 0.0 0.72 9.7 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic protein of unknown function (DUF829) Esterase_phd PF10503.9 ORX48217.1 - 0.016 14.7 0.0 2.6 7.5 0.0 2.4 1 1 1 2 2 2 0 Esterase PHB depolymerase Lipase_3 PF01764.25 ORX48217.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Ric8 PF10165.9 ORX48218.1 - 3e-35 122.2 0.0 3.6e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Ric8 PF10165.9 ORX48219.1 - 1.3e-46 159.6 0.0 1.4e-46 159.5 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Enkurin PF13864.6 ORX48220.1 - 0.012 16.1 1.2 0.012 16.1 1.2 3.0 1 1 2 3 3 3 0 Calmodulin-binding Borrelia_REV PF03978.13 ORX48220.1 - 1.2 9.1 5.5 0.41 10.6 2.6 1.6 2 0 0 2 2 2 0 Borrelia burgdorferi REV protein MIP-T3_C PF17749.1 ORX48220.1 - 1.5 8.8 15.2 0.06 13.3 7.9 2.3 3 0 0 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region CENP-F_leu_zip PF10473.9 ORX48220.1 - 8 6.5 23.8 3 7.9 1.9 3.4 2 2 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sel1 PF08238.12 ORX48221.1 - 1.4e-16 60.6 14.6 1.5e-06 28.7 0.6 6.6 7 0 0 7 7 7 5 Sel1 repeat TraF PF13728.6 ORX48221.1 - 0.023 14.5 2.8 0.066 13.0 2.8 1.8 1 0 0 1 1 1 0 F plasmid transfer operon protein TPR_2 PF07719.17 ORX48221.1 - 0.29 11.4 7.4 0.52 10.5 1.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX48221.1 - 0.84 10.6 2.8 2.5 9.1 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SelP_N PF04592.14 ORX48221.1 - 4.2 6.7 12.4 12 5.3 12.4 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ATP-synt_Eps PF04627.13 ORX48222.1 - 1.5e-20 72.9 1.0 2.3e-20 72.3 1.0 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain Choline_transpo PF04515.12 ORX48223.1 - 4.2e-55 187.2 31.2 4.2e-55 187.2 31.2 2.2 2 0 0 2 2 2 2 Plasma-membrane choline transporter AAA PF00004.29 ORX48224.1 - 4.6e-14 53.0 0.0 1.3e-13 51.5 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 ORX48224.1 - 1.6e-10 41.0 0.1 5.7e-10 39.2 0.1 1.9 1 0 0 1 1 1 1 AAA lid domain AAA_16 PF13191.6 ORX48224.1 - 5.3e-09 36.7 0.0 4.3e-08 33.7 0.0 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX48224.1 - 1.1e-07 32.2 0.3 2.9e-07 30.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.11 ORX48224.1 - 1.3e-06 28.2 0.0 4.3e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_19 PF13245.6 ORX48224.1 - 0.0021 18.4 0.8 0.025 14.9 0.0 2.7 3 0 0 3 3 3 1 AAA domain Microtub_bd PF16796.5 ORX48224.1 - 0.0051 16.8 0.0 0.014 15.3 0.0 1.8 2 0 0 2 2 2 1 Microtubule binding ATPase_2 PF01637.18 ORX48224.1 - 0.054 13.4 0.9 0.11 12.4 0.0 2.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ORX48224.1 - 0.069 13.1 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 ORX48224.1 - 0.076 13.0 0.0 0.31 11.1 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_assoc_2 PF16193.5 ORX48224.1 - 0.083 13.2 1.7 0.76 10.2 0.0 3.1 3 0 0 3 3 3 0 AAA C-terminal domain DUF1087 PF06465.13 ORX48224.1 - 0.16 12.0 6.8 4.3 7.5 0.6 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) SnAC PF14619.6 ORX48224.1 - 0.27 11.9 6.8 12 6.6 1.4 3.4 2 0 0 2 2 2 0 Snf2-ATP coupling, chromatin remodelling complex ParG PF09274.10 ORX48224.1 - 9.4 6.5 8.3 21 5.3 0.4 3.9 4 0 0 4 4 4 0 ParG CLU PF13236.6 ORX48226.1 - 9.5e-83 277.4 0.0 2.6e-82 275.9 0.0 1.7 2 0 0 2 2 2 1 Clustered mitochondria eIF3_p135 PF12807.7 ORX48226.1 - 5.6e-47 160.0 0.0 1.3e-46 158.8 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 ORX48226.1 - 2.8e-21 75.7 0.2 2.3e-20 72.7 0.3 2.4 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 ORX48226.1 - 6e-21 74.5 11.7 1.6e-08 34.7 0.1 3.7 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ORX48226.1 - 1.4e-20 72.5 4.9 1.4e-07 31.1 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat DUF727 PF05303.12 ORX48226.1 - 3.9e-05 23.7 0.0 0.00016 21.7 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF727) TPR_8 PF13181.6 ORX48226.1 - 0.079 13.2 2.5 2.7 8.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Ntox10 PF15520.6 ORX48226.1 - 0.092 12.6 0.4 0.43 10.4 0.1 2.0 2 0 0 2 2 2 0 Novel toxin 10 TPR_16 PF13432.6 ORX48226.1 - 0.11 13.1 2.4 5.3 7.8 0.0 4.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Nyv1_N PF09426.10 ORX48226.1 - 0.17 11.9 0.0 0.5 10.4 0.0 1.7 1 0 0 1 1 1 0 Vacuolar R-SNARE Nyv1 N terminal FAM176 PF14851.6 ORX48226.1 - 0.34 10.6 6.6 0.88 9.2 6.6 1.6 1 0 0 1 1 1 0 FAM176 family TPR_1 PF00515.28 ORX48226.1 - 2.5 8.1 7.0 1.5e+02 2.4 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat MSSP PF03940.13 ORX48228.1 - 0.08 12.5 14.1 1.2 8.8 4.9 2.6 1 1 1 2 2 2 0 Male specific sperm protein zf-C2H2_4 PF13894.6 ORX48229.1 - 0.15 13.0 0.2 0.43 11.5 0.2 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger Kelch_4 PF13418.6 ORX48231.1 - 2.2e-07 30.8 3.8 0.0055 16.7 1.1 4.3 3 2 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX48231.1 - 7.3e-07 29.3 6.9 0.0056 16.9 3.2 3.7 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48231.1 - 1.9e-05 24.8 1.4 0.0038 17.5 1.2 3.2 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ORX48231.1 - 0.00023 21.1 0.1 0.041 13.9 0.0 3.0 3 1 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ORX48231.1 - 0.0012 18.4 4.3 0.01 15.4 1.0 3.5 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ORX48231.1 - 0.031 14.3 0.0 1.6 8.8 0.1 2.5 2 1 0 2 2 2 0 Kelch motif DUF3097 PF11296.8 ORX48231.1 - 0.12 11.6 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3097) Kelch_4 PF13418.6 ORX48232.1 - 5.2e-08 32.8 2.6 0.012 15.6 0.0 3.8 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX48232.1 - 3.4e-07 30.4 5.7 8.8e-07 29.1 0.1 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48232.1 - 4.4e-06 26.8 0.2 0.0059 16.8 0.0 3.3 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ORX48232.1 - 8.2e-05 22.5 0.0 0.27 11.3 0.0 2.7 2 0 0 2 2 2 2 Kelch motif VSP PF03302.13 ORX48232.1 - 0.055 12.3 0.5 0.091 11.6 0.5 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein Kelch_1 PF01344.25 ORX48232.1 - 0.072 12.7 2.0 3.7 7.2 0.4 3.2 2 1 0 2 2 2 0 Kelch motif HSV_VP16_C PF12149.8 ORX48233.1 - 0.031 14.4 0.1 0.074 13.1 0.1 1.6 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal Kelch_6 PF13964.6 ORX48234.1 - 7.5e-12 45.1 6.5 0.0042 17.3 0.0 5.4 5 0 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 ORX48234.1 - 7.8e-12 45.0 15.6 0.019 15.0 0.1 6.3 5 2 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX48234.1 - 5.9e-10 38.9 0.9 0.94 9.5 0.0 5.2 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 ORX48234.1 - 1.5e-06 27.6 5.9 0.007 15.9 0.0 5.6 5 1 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ORX48234.1 - 5.2e-06 26.6 9.2 0.00021 21.5 0.0 5.1 5 1 0 5 5 5 1 Galactose oxidase, central domain HSV_VP16_C PF12149.8 ORX48234.1 - 0.15 12.2 0.2 0.32 11.1 0.2 1.4 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal Kelch_4 PF13418.6 ORX48236.1 - 5.7e-12 45.5 4.5 0.0017 18.3 0.1 3.7 3 2 0 3 3 3 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX48236.1 - 3e-11 43.3 5.1 2.9e-07 30.6 0.1 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48236.1 - 2.9e-07 30.5 4.2 0.0015 18.8 0.5 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ORX48236.1 - 4e-07 29.9 0.4 0.87 9.6 0.5 3.5 3 1 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ORX48236.1 - 0.0047 16.5 1.1 0.33 10.6 0.1 3.4 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ORX48236.1 - 0.031 14.2 1.6 11 6.2 0.0 3.4 3 1 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ORX48237.1 - 3.7e-07 30.0 0.2 0.0092 16.0 0.1 3.2 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX48237.1 - 6e-05 23.2 0.3 0.0024 18.1 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48237.1 - 0.00016 21.8 1.3 0.016 15.5 0.3 2.9 2 1 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ORX48237.1 - 0.0059 16.6 0.0 4.6 7.3 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ORX48237.1 - 0.08 12.5 1.9 4.1 7.1 0.3 3.1 2 1 0 2 2 2 0 Kelch motif VSP PF03302.13 ORX48237.1 - 0.27 10.1 0.5 0.35 9.7 0.5 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Kelch_6 PF13964.6 ORX48238.1 - 0.011 16.0 0.5 1.7 9.0 0.1 2.4 2 0 0 2 2 2 0 Kelch motif HSV_VP16_C PF12149.8 ORX48238.1 - 0.061 13.4 0.2 0.12 12.5 0.2 1.4 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal Kelch_4 PF13418.6 ORX48239.1 - 9.6e-09 35.1 5.1 0.0038 17.2 0.0 3.8 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48239.1 - 9.2e-06 25.8 4.1 0.0067 16.7 0.5 3.3 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ORX48239.1 - 1.1e-05 25.2 0.4 0.086 12.9 0.0 3.2 3 1 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ORX48239.1 - 1.4e-05 25.2 4.0 4.1e-05 23.7 0.1 2.9 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX48239.1 - 0.0023 17.8 0.1 2.7 8.1 0.0 2.7 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ORX48239.1 - 0.01 15.4 3.8 7.8 6.2 0.0 4.1 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ORX48240.1 - 0.0014 18.1 0.6 0.0093 15.5 0.1 2.3 2 1 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ORX48240.1 - 0.0028 17.9 0.1 0.79 10.1 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ORX48240.1 - 0.0031 17.5 1.8 0.038 14.0 0.1 2.6 2 1 0 2 2 2 1 Galactose oxidase, central domain HSV_VP16_C PF12149.8 ORX48240.1 - 0.068 13.3 0.2 0.12 12.4 0.2 1.3 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal VSP PF03302.13 ORX48241.1 - 8.2e-05 21.6 0.3 9.7e-05 21.4 0.3 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein Phage_holin_2_4 PF16082.5 ORX48241.1 - 0.0074 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Bacteriophage holin family, superfamily II-like Kelch_3 PF13415.6 ORX48242.1 - 3.7e-09 36.6 2.7 5e-05 23.5 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 ORX48242.1 - 5.8e-09 35.8 8.9 0.079 13.0 0.0 4.6 3 2 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX48242.1 - 1.8e-08 34.2 0.5 0.17 11.9 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 ORX48242.1 - 5.6e-07 29.6 6.3 0.003 17.8 0.7 3.6 3 1 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ORX48242.1 - 3.6e-05 23.6 0.0 0.029 14.3 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ORX48242.1 - 0.00015 21.3 5.6 1.1 8.9 0.8 4.1 3 1 0 3 3 3 2 Kelch motif Glyco_transf_5 PF08323.11 ORX48243.1 - 1.6e-18 67.3 0.1 5.9e-18 65.5 0.1 1.9 1 1 0 1 1 1 1 Starch synthase catalytic domain Glycos_transf_1 PF00534.20 ORX48243.1 - 3.1e-14 52.9 0.0 7.3e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX48243.1 - 3.9e-13 50.0 0.0 7.6e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX48243.1 - 2.4e-06 27.7 0.3 0.0048 16.9 0.0 3.4 2 1 1 3 3 3 2 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX48243.1 - 3.9e-06 27.4 5.0 0.0001 22.8 1.5 3.8 3 1 0 3 3 3 1 Glycosyl transferase 4-like domain TPR_1 PF00515.28 ORX48244.1 - 1.3e-13 50.2 18.8 0.028 14.2 0.5 8.9 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX48244.1 - 3.4e-11 42.4 24.5 0.069 13.3 0.0 9.3 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX48244.1 - 1.6e-10 40.3 12.5 0.017 15.3 0.0 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX48244.1 - 2.2e-10 40.5 8.4 0.027 15.3 0.2 6.4 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX48244.1 - 3.1e-07 30.8 18.8 0.0079 16.7 0.3 6.6 6 1 2 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX48244.1 - 6.6e-05 23.1 6.1 0.019 15.2 0.2 5.0 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ORX48244.1 - 0.00034 20.9 14.2 0.023 15.0 0.1 6.7 5 2 0 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX48244.1 - 0.0024 18.1 7.9 20 5.9 0.2 6.5 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX48244.1 - 0.0052 17.4 13.1 0.024 15.3 1.1 5.9 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX48244.1 - 0.0063 16.2 4.7 17 5.2 0.0 5.7 6 1 0 6 6 6 0 TPR repeat TPR_21 PF09976.9 ORX48244.1 - 0.059 13.1 2.3 0.31 10.7 0.2 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 ORX48244.1 - 0.086 13.2 0.0 14 6.1 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX48244.1 - 0.26 11.4 14.0 0.74 10.0 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat IBR PF01485.21 ORX48245.1 - 7.3e-10 38.9 20.1 1.8e-07 31.3 12.2 4.6 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain RRM_1 PF00076.22 ORX48246.1 - 5.2e-12 45.4 0.0 4.9e-06 26.3 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lzipper-MIP1 PF14389.6 ORX48247.1 - 0.011 16.0 3.6 0.036 14.4 3.6 1.9 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 DUF4783 PF16022.5 ORX48247.1 - 0.19 11.9 0.2 0.42 10.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4783) Phage_CRI PF05144.14 ORX48247.1 - 2.3 7.5 4.3 1.6 8.0 0.0 2.1 2 0 0 2 2 2 0 Phage replication protein CRI zf-RING_2 PF13639.6 ORX48248.1 - 1.9e-13 50.5 7.1 3.5e-13 49.6 7.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX48248.1 - 4.5e-10 39.1 2.5 9e-10 38.1 2.5 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX48248.1 - 1e-09 38.1 6.1 1.8e-09 37.3 6.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX48248.1 - 1.6e-07 31.5 8.7 3.3e-07 30.5 8.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX48248.1 - 1.1e-06 28.5 3.3 1.7e-06 27.8 3.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX48248.1 - 1.3e-06 28.2 4.1 2.2e-06 27.4 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX48248.1 - 2.5e-05 24.0 4.0 4.3e-05 23.3 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX48248.1 - 0.0002 21.3 3.6 0.00081 19.4 3.9 1.9 1 1 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ORX48248.1 - 0.00026 20.6 4.2 0.0004 19.9 4.2 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ORX48248.1 - 0.00039 20.4 3.1 0.00076 19.5 3.1 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ORX48248.1 - 0.013 15.3 6.7 0.027 14.3 6.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ORX48248.1 - 0.024 14.8 5.1 0.046 13.9 5.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ORX48248.1 - 0.05 13.4 3.8 0.12 12.3 3.8 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RINGv PF12906.7 ORX48248.1 - 0.3 11.2 5.2 0.56 10.4 5.0 1.6 1 1 0 1 1 1 0 RING-variant domain zf-C3H2C3 PF17122.5 ORX48248.1 - 1.3 9.1 6.3 3.3 7.8 6.3 1.7 1 0 0 1 1 1 0 Zinc-finger zf-RING_4 PF14570.6 ORX48248.1 - 1.4 8.8 4.1 1.9 8.4 3.3 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ANAPC4_WD40 PF12894.7 ORX48249.1 - 2.1e-10 40.8 3.4 0.0001 22.5 0.0 5.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX48249.1 - 4.2e-10 39.8 1.7 0.00025 21.0 0.0 4.1 2 2 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ORX48249.1 - 1.5e-07 32.0 13.2 12 7.0 0.1 8.0 8 0 0 8 8 8 3 WD domain, G-beta repeat PD40 PF07676.12 ORX48249.1 - 0.0011 18.8 0.9 34 4.5 0.0 4.7 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ORX48249.1 - 0.004 16.3 0.3 3.3 6.6 0.0 3.3 3 1 1 4 4 4 2 Coatomer WD associated region Glutaredoxin PF00462.24 ORX48250.1 - 5.1e-18 65.0 0.0 8.3e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin IGPS PF00218.21 ORX48251.1 - 9.7e-91 303.4 0.1 2.4e-90 302.2 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase PRAI PF00697.22 ORX48251.1 - 5e-50 170.0 0.2 3.7e-42 144.3 0.1 2.4 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase GATase PF00117.28 ORX48251.1 - 5e-47 160.1 0.0 8.8e-47 159.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX48251.1 - 6.9e-09 35.8 0.0 2.4e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 ORX48251.1 - 0.0014 18.4 0.2 0.12 12.1 0.0 3.2 3 0 0 3 3 3 1 Quinolinate phosphoribosyl transferase, C-terminal domain NanE PF04131.14 ORX48251.1 - 0.015 14.5 1.0 13 4.9 0.0 3.9 5 0 0 5 5 5 0 Putative N-acetylmannosamine-6-phosphate epimerase DUF4588 PF15251.6 ORX48252.1 - 0.0005 19.9 0.0 0.00084 19.2 0.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) UQ_con PF00179.26 ORX48253.1 - 4e-38 130.2 0.1 4.8e-38 130.0 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme HSP70 PF00012.20 ORX48254.1 - 1.2e-05 23.8 0.0 1.7e-05 23.2 0.0 1.4 1 1 0 1 1 1 1 Hsp70 protein Pkinase PF00069.25 ORX48255.1 - 6.7e-68 228.9 0.0 8.9e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48255.1 - 3.1e-45 154.5 0.0 4.8e-45 153.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX48255.1 - 9.3e-22 77.2 0.0 2.3e-21 75.9 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 ORX48255.1 - 9.5e-10 38.2 0.2 2.4e-09 36.9 0.2 1.6 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX48255.1 - 7.8e-06 24.9 0.1 1.7e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX48255.1 - 0.0011 18.0 0.5 0.0042 16.1 0.5 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX48255.1 - 0.0042 16.5 0.1 0.009 15.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX48255.1 - 0.028 14.3 1.7 1.2 9.1 1.7 2.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ORX48255.1 - 0.096 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Usp PF00582.26 ORX48256.1 - 1.5e-20 74.2 0.0 2.9e-20 73.2 0.0 1.5 1 1 0 1 1 1 1 Universal stress protein family CENP-H PF05837.12 ORX48257.1 - 1.9e-05 25.0 0.7 1.9e-05 25.0 0.7 2.1 2 1 0 2 2 2 1 Centromere protein H (CENP-H) APG6_N PF17675.1 ORX48257.1 - 0.007 16.9 4.8 0.007 16.9 4.8 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region YabA PF06156.13 ORX48257.1 - 0.011 16.4 4.6 0.011 16.4 1.9 2.1 2 0 0 2 2 2 0 Initiation control protein YabA PBP-Tp47_a PF14889.6 ORX48257.1 - 0.065 12.9 0.1 0.096 12.3 0.1 1.3 1 0 0 1 1 1 0 Penicillin-binding protein Tp47 domain a Sec34 PF04136.15 ORX48257.1 - 0.075 12.9 5.7 0.035 14.0 2.0 2.0 2 0 0 2 2 2 0 Sec34-like family bZIP_1 PF00170.21 ORX48257.1 - 0.14 12.3 3.4 0.25 11.5 0.4 2.7 2 1 1 3 3 3 0 bZIP transcription factor Sec20 PF03908.13 ORX48257.1 - 0.16 11.9 4.0 6.9 6.7 0.3 3.1 1 1 0 2 2 2 0 Sec20 SH3_19 PF18597.1 ORX48257.1 - 0.17 11.7 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain JIP_LZII PF16471.5 ORX48257.1 - 0.33 11.1 8.6 6.2 7.1 0.2 3.0 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Cep57_CLD_2 PF14197.6 ORX48257.1 - 3 8.0 9.3 0.69 10.0 3.3 2.6 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Zn-C2H2_12 PF18112.1 ORX48258.1 - 0.016 15.7 0.5 0.037 14.5 0.5 1.7 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain zf-WRNIP1_ubi PF18279.1 ORX48258.1 - 0.091 13.4 0.7 0.47 11.2 0.7 2.2 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Sgf11 PF08209.11 ORX48258.1 - 0.11 12.1 1.3 1.7 8.3 0.1 2.5 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Sec2p PF06428.11 ORX48259.1 - 2.8e-13 49.6 8.7 2.8e-13 49.6 8.7 2.6 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p V_ATPase_I PF01496.19 ORX48259.1 - 0.64 7.9 5.6 0.93 7.3 5.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 ORX48259.1 - 0.92 9.6 16.5 1.8 8.7 16.5 1.4 1 0 0 1 1 1 0 Tropomyosin like DUF5401 PF17380.2 ORX48259.1 - 4.1 5.4 11.8 5.7 4.9 11.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF2730 PF10805.8 ORX48259.1 - 9.6 6.4 7.5 1.4 9.0 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Atx10homo_assoc PF09759.9 ORX48260.1 - 6.4e-32 109.5 1.8 1.6e-31 108.2 0.0 2.7 3 0 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain SapB_1 PF05184.15 ORX48260.1 - 0.59 10.2 4.9 1 9.4 0.6 3.2 3 0 0 3 3 3 0 Saposin-like type B, region 1 AMP-binding PF00501.28 ORX48261.1 - 1.1e-104 350.4 0.0 1.4e-104 350.0 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX48261.1 - 2.7e-06 28.3 0.1 1e-05 26.4 0.1 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LIP PF03583.14 ORX48262.1 - 2.8e-71 240.2 0.5 3.9e-71 239.7 0.5 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 ORX48262.1 - 0.0013 18.3 1.7 0.32 10.4 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family LIP PF03583.14 ORX48263.1 - 1.1e-73 248.1 0.0 1.4e-73 247.7 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 ORX48263.1 - 0.041 13.4 1.1 2.2 7.7 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Fanconi_A_N PF15865.5 ORX48264.1 - 8.3e-05 22.1 0.1 0.00013 21.5 0.1 1.4 1 0 0 1 1 1 1 Fanconi anaemia group A protein N terminus Sigma54_activ_2 PF14532.6 ORX48265.1 - 0.06 13.5 0.0 0.9 9.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain RRM_1 PF00076.22 ORX48266.1 - 0.0012 18.6 0.2 0.0036 17.1 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MT0933_antitox PF14013.6 ORX48266.1 - 0.005 17.1 0.2 0.012 15.9 0.2 1.6 1 0 0 1 1 1 1 MT0933-like antitoxin protein CG-1 PF03859.16 ORX48266.1 - 0.058 13.2 0.4 0.1 12.4 0.4 1.4 1 0 0 1 1 1 0 CG-1 domain Oxidored_FMN PF00724.20 ORX48268.1 - 4e-101 338.7 0.0 5.3e-101 338.3 0.0 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Neisseria_TspB PF05616.13 ORX48268.1 - 4.4 5.7 8.3 6 5.2 8.3 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein Coatomer_WDAD PF04053.14 ORX48269.1 - 5.3e-170 566.3 0.0 2.4e-169 564.1 0.0 1.9 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 ORX48269.1 - 1.3e-43 146.1 6.7 1.1e-08 35.6 0.0 8.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48269.1 - 1.2e-09 38.3 0.1 0.82 10.0 0.0 7.5 5 3 1 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ORX48269.1 - 6.2e-05 23.0 0.0 0.74 9.9 0.0 3.8 2 2 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 ORX48269.1 - 0.09 11.5 0.1 12 4.5 0.1 2.5 2 0 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 ORX48269.1 - 0.12 11.0 0.2 3.8 6.0 0.1 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 TPR_14 PF13428.6 ORX48269.1 - 0.17 12.8 0.2 13 6.9 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Ge1_WD40 PF16529.5 ORX48269.1 - 0.49 9.3 3.4 2.5 7.0 0.1 3.1 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CysA_C_terminal PF17850.1 ORX48270.1 - 0.12 12.9 0.4 1.6 9.4 0.5 2.4 2 1 0 2 2 2 0 CysA C-terminal regulatory domain IPK PF03770.16 ORX48271.1 - 2.7e-51 174.3 0.1 6.3e-51 173.0 0.0 1.7 2 0 0 2 2 2 1 Inositol polyphosphate kinase Pribosyltran PF00156.27 ORX48272.1 - 2.5e-25 88.8 0.0 3.3e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain PRTase_2 PF15609.6 ORX48272.1 - 0.0027 17.2 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase UPRTase PF14681.6 ORX48272.1 - 0.003 17.0 0.1 0.0051 16.3 0.1 1.4 1 1 0 1 1 1 1 Uracil phosphoribosyltransferase Y_phosphatase2 PF03162.13 ORX48272.1 - 0.11 12.0 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family HMG_box PF00505.19 ORX48273.1 - 3.6e-15 56.1 0.5 3.6e-15 56.1 0.5 2.4 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX48273.1 - 0.00012 22.6 0.1 0.00012 22.6 0.1 1.9 2 0 0 2 2 2 1 HMG-box domain MATalpha_HMGbox PF04769.12 ORX48273.1 - 0.09 12.1 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box PH PF00169.29 ORX48274.1 - 0.0093 16.5 0.0 0.044 14.3 0.0 2.2 1 1 0 1 1 1 1 PH domain REC114-like PF15165.6 ORX48274.1 - 0.15 11.8 0.5 0.44 10.3 0.5 1.7 1 0 0 1 1 1 0 Meiotic recombination protein REC114-like Mis14 PF08641.12 ORX48275.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Kinetochore protein Mis14 like HAMP PF00672.25 ORX48276.1 - 4.8e-171 555.2 77.4 3.4e-09 36.9 0.1 23.2 22 0 0 22 22 22 21 HAMP domain HATPase_c PF02518.26 ORX48276.1 - 7.4e-31 107.0 0.2 8.5e-30 103.6 0.2 3.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX48276.1 - 4.4e-28 97.7 10.7 2.8e-25 88.7 0.1 5.5 6 0 0 6 6 6 2 Response regulator receiver domain HisKA PF00512.25 ORX48276.1 - 6.5e-18 64.5 1.3 1.1e-16 60.6 0.4 4.0 2 0 0 2 2 1 1 His Kinase A (phospho-acceptor) domain HTH_6 PF01418.17 ORX48276.1 - 8e-15 54.6 3.4 16 5.6 0.0 15.7 17 0 0 17 17 17 0 Helix-turn-helix domain, rpiR family SpoIIID PF12116.8 ORX48276.1 - 3.9e-09 36.5 34.4 14 5.9 0.0 17.2 19 0 0 19 19 19 0 Stage III sporulation protein D ApoLp-III PF07464.11 ORX48276.1 - 0.002 18.2 102.9 1.9 8.6 0.5 19.5 4 2 17 22 22 22 6 Apolipophorin-III precursor (apoLp-III) ImcF-related_N PF14331.6 ORX48276.1 - 0.0046 16.4 9.0 1.1e+02 2.1 0.0 8.8 9 3 1 10 10 10 0 ImcF-related N-terminal domain DUF4795 PF16043.5 ORX48276.1 - 0.018 14.6 49.0 1.3 8.5 1.0 13.5 6 4 6 12 12 12 0 Domain of unknown function (DUF4795) VHS PF00790.19 ORX48276.1 - 0.023 14.5 0.1 0.21 11.4 0.1 2.8 1 0 0 1 1 1 0 VHS domain WXG100 PF06013.12 ORX48276.1 - 0.61 10.4 65.4 0.17 12.2 0.1 17.3 20 1 2 22 22 22 0 Proteins of 100 residues with WXG DUF2536 PF10750.9 ORX48276.1 - 2.3 8.2 9.5 13 5.8 0.4 6.4 8 0 0 8 8 7 0 Protein of unknown function (DUF2536) DUF1759 PF03564.15 ORX48276.1 - 4.1 7.3 35.9 27 4.7 0.0 14.1 19 0 0 19 19 18 0 Protein of unknown function (DUF1759) ADP_ribosyl_GH PF03747.14 ORX48278.1 - 1.2e-43 149.9 0.0 2.6e-43 148.8 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase Glyoxalase PF00903.25 ORX48279.1 - 1.7e-09 37.9 0.0 4.7e-09 36.5 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ORX48279.1 - 0.0086 16.3 0.0 0.01 16.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ORX48279.1 - 0.02 14.8 0.0 2.1 8.3 0.0 2.5 2 2 1 3 3 3 0 Glyoxalase-like domain Lyase_1 PF00206.20 ORX48280.1 - 3.4e-42 144.9 0.1 4.9e-42 144.4 0.1 1.1 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 ORX48280.1 - 6.4e-18 65.1 0.3 1e-16 61.2 0.0 2.6 3 0 0 3 3 3 1 Adenylosuccinate lyase C-terminus Mito_carr PF00153.27 ORX48281.1 - 3.5e-48 161.5 2.6 2.4e-17 62.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Forkhead PF00250.18 ORX48282.1 - 6.4e-34 116.1 0.1 1.2e-33 115.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 ORX48282.1 - 0.11 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 linker histone H1 and H5 family FOXP-CC PF16159.5 ORX48283.1 - 0.0008 20.0 3.4 0.1 13.2 0.5 3.3 1 1 1 2 2 2 2 FOXP coiled-coil domain NicO PF03824.16 ORX48283.1 - 0.39 10.0 3.0 0.76 9.1 3.0 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein RA PF00788.23 ORX48284.1 - 6.5e-14 52.3 3.0 3.8e-05 24.2 0.0 4.5 3 1 1 4 4 4 2 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 ORX48284.1 - 4e-08 32.7 0.0 9.3e-08 31.6 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX48284.1 - 0.00019 21.2 0.0 0.00042 20.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX48284.1 - 0.046 14.0 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Bacterial SH3 domain RasGAP PF00616.19 ORX48285.1 - 6.5e-27 94.6 0.1 5.1e-18 65.6 0.0 2.7 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase Chitin_synth_2 PF03142.15 ORX48286.1 - 2e-237 789.0 0.9 2.7e-237 788.6 0.9 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX48286.1 - 9.2e-137 457.1 0.0 1.4e-136 456.5 0.0 1.3 1 0 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ORX48286.1 - 2.7e-18 65.9 0.2 2.1e-14 53.4 0.0 2.9 3 0 0 3 3 2 2 Cytochrome b5-like Heme/Steroid binding domain Glyco_tranf_2_3 PF13641.6 ORX48286.1 - 6.5e-10 39.3 0.0 1.7e-08 34.7 0.0 2.4 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX48286.1 - 3.1e-08 33.8 5.0 3.1e-08 33.8 5.0 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Sigma54_activat PF00158.26 ORX48286.1 - 0.0015 18.3 0.2 0.0031 17.3 0.2 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Glycos_transf_2 PF00535.26 ORX48286.1 - 0.013 15.4 0.0 0.69 9.7 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 AAA_22 PF13401.6 ORX48286.1 - 0.042 14.1 0.0 0.16 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX48286.1 - 0.05 14.0 0.1 0.21 12.0 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain Glyco_transf_21 PF13506.6 ORX48286.1 - 0.055 12.9 0.0 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 21 RNA_helicase PF00910.22 ORX48286.1 - 0.057 13.8 0.3 0.53 10.7 0.1 2.9 3 1 0 3 3 2 0 RNA helicase Microtub_bd PF16796.5 ORX48286.1 - 0.1 12.5 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Microtubule binding WBS_methylT PF12589.8 ORX48287.1 - 4.2e-19 69.1 8.7 6.6e-19 68.5 8.7 1.3 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 ORX48287.1 - 2.2e-11 44.2 0.0 3.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX48287.1 - 4.6e-10 40.1 0.0 8.8e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX48287.1 - 1.4e-07 32.1 0.0 4.5e-07 30.5 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX48287.1 - 3.8e-07 30.1 0.0 5.1e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX48287.1 - 9e-05 22.3 0.0 0.00015 21.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ORX48287.1 - 0.0087 16.4 0.0 0.025 14.9 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase CMAS PF02353.20 ORX48287.1 - 0.014 14.7 0.0 0.024 13.9 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PCMT PF01135.19 ORX48287.1 - 0.052 13.3 0.0 0.082 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 ORX48287.1 - 0.091 12.7 0.0 0.18 11.8 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_S13 PF00416.22 ORX48288.1 - 6.6e-21 75.0 1.7 8.7e-19 68.2 1.7 2.0 1 1 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX48288.1 - 0.0022 16.9 0.0 0.0023 16.8 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF3945 PF13101.6 ORX48288.1 - 0.0057 16.4 0.0 0.01 15.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3945) Vps5 PF09325.10 ORX48289.1 - 4.9e-16 59.0 6.5 4.9e-16 59.0 6.5 2.3 2 1 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 ORX48289.1 - 5.4e-09 36.0 0.4 5.4e-09 36.0 0.4 2.0 2 0 0 2 2 2 1 PX domain BAR PF03114.18 ORX48289.1 - 0.0094 15.6 6.8 0.0094 15.6 6.8 1.8 2 0 0 2 2 2 1 BAR domain BBP1_N PF15271.6 ORX48289.1 - 3.3 8.5 7.4 0.5 11.1 1.3 2.2 1 1 1 2 2 2 0 Spindle pole body component BBP1, Mps2-binding protein Cyclin_N PF00134.23 ORX48290.1 - 2.8e-08 33.6 0.0 3.4e-08 33.3 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX48290.1 - 5.5e-08 33.3 0.0 7e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Cyclin NifU_N PF01592.16 ORX48291.1 - 6.9e-56 187.9 0.1 7.7e-56 187.7 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Ribosomal_L35Ae PF01247.18 ORX48292.1 - 6.2e-43 144.9 1.3 7e-43 144.7 1.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 ORX48292.1 - 0.0031 17.7 0.0 0.54 10.5 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Ndc1_Nup PF09531.10 ORX48293.1 - 1.4e-47 162.7 11.2 2e-47 162.3 11.2 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup WD40 PF00400.32 ORX48294.1 - 1e-11 45.1 0.1 0.00014 22.6 0.0 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48294.1 - 6.6e-09 36.0 0.0 0.0008 19.7 0.0 3.5 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX48294.1 - 0.0045 16.0 0.1 0.32 9.9 0.0 2.4 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 ORX48294.1 - 0.019 14.2 0.3 0.39 9.9 0.0 2.2 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Spindle_Spc25 PF08234.12 ORX48296.1 - 1.2e-19 70.3 0.1 8.7e-18 64.3 0.1 2.7 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 ORX48296.1 - 0.00014 20.9 20.3 0.00021 20.3 20.3 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein SHE3 PF17078.5 ORX48296.1 - 0.052 13.3 13.4 0.08 12.7 13.4 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 MoaF PF10703.9 ORX48296.1 - 0.14 12.1 0.4 3.9 7.4 0.2 2.4 2 1 0 2 2 2 0 MoaF N-terminal domain DUF3584 PF12128.8 ORX48296.1 - 0.26 8.8 17.4 0.34 8.4 17.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF5401 PF17380.2 ORX48296.1 - 0.48 8.4 17.8 0.6 8.1 17.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CHASE3 PF05227.13 ORX48296.1 - 1.3 8.9 14.9 0.23 11.3 7.8 2.2 1 1 1 2 2 2 0 CHASE3 domain DUF4407 PF14362.6 ORX48296.1 - 3.1 7.1 13.6 4.9 6.4 13.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Muted PF14942.6 ORX48296.1 - 4.7 7.5 20.2 11 6.3 18.7 2.4 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein Seryl_tRNA_N PF02403.22 ORX48296.1 - 6.4 7.0 17.6 1.2 9.3 13.1 2.0 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain V_ATPase_I PF01496.19 ORX48296.1 - 9.1 4.1 10.0 11 3.8 10.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pyrophosphatase PF00719.19 ORX48297.1 - 2e-44 151.2 0.1 3.3e-44 150.5 0.1 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase TFIID-18kDa PF02269.16 ORX48298.1 - 7.6e-31 106.0 0.1 2.6e-30 104.3 0.0 1.9 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Biliv-reduc_cat PF09166.10 ORX48298.1 - 0.024 14.9 0.0 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 Biliverdin reductase, catalytic ubiquitin PF00240.23 ORX48299.1 - 2.8e-13 49.4 0.0 5.5e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 ORX48299.1 - 8.4e-09 35.2 1.6 1.3e-08 34.6 0.1 2.2 2 0 0 2 2 2 1 UBA/TS-N domain STI1 PF17830.1 ORX48299.1 - 6.9e-06 25.9 10.3 0.0015 18.4 2.3 3.2 2 1 2 4 4 4 2 STI1 domain Rad60-SLD_2 PF13881.6 ORX48299.1 - 0.012 15.7 0.3 0.081 13.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ORX48299.1 - 0.015 15.4 0.0 0.078 13.0 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain CUE PF02845.16 ORX48299.1 - 0.022 14.4 0.1 0.063 13.0 0.1 1.8 1 0 0 1 1 1 0 CUE domain Rad60-SLD PF11976.8 ORX48299.1 - 0.025 14.4 0.0 0.048 13.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX48299.1 - 0.034 14.7 0.9 0.18 12.4 0.0 2.6 3 1 0 3 3 3 0 DUF2407 ubiquitin-like domain Rhodanese PF00581.20 ORX48300.1 - 3.5e-16 59.7 0.1 4.2e-16 59.4 0.1 1.1 1 0 0 1 1 1 1 Rhodanese-like domain DUF2433 PF10360.9 ORX48300.1 - 0.045 13.8 0.0 0.051 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) G-alpha PF00503.20 ORX48301.1 - 1.5e-104 349.9 0.2 1.9e-104 349.6 0.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX48301.1 - 2.8e-14 53.0 0.1 1.4e-09 37.6 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX48301.1 - 0.0055 16.1 0.3 2.1 7.6 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX48301.1 - 0.0083 16.3 0.3 6.1 7.1 0.1 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ORX48301.1 - 0.15 11.4 0.0 0.49 9.7 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ribosomal_L37e PF01907.19 ORX48302.1 - 2.6e-27 94.7 12.0 4.4e-27 94.0 12.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 ORX48302.1 - 0.0074 16.3 1.6 0.011 15.7 1.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 ORX48302.1 - 0.027 14.5 0.9 0.037 14.0 0.9 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_5 PF14634.6 ORX48302.1 - 0.05 13.6 4.0 0.076 13.0 4.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX48302.1 - 0.39 10.6 5.0 0.62 10.0 5.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX48302.1 - 0.49 10.3 4.6 0.76 9.7 4.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 ORX48303.1 - 6.6e-12 44.9 1.2 1.8e-11 43.5 1.2 1.8 1 0 0 1 1 1 1 SAP domain RSB_motif PF16294.5 ORX48303.1 - 4.9e-11 42.8 0.2 4.9e-11 42.8 0.2 2.9 2 1 0 2 2 2 1 RNSP1-SAP18 binding (RSB) motif RRM_1 PF00076.22 ORX48303.1 - 0.0062 16.3 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pinin_SDK_memA PF04696.13 ORX48303.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.9 3 0 0 3 3 3 0 pinin/SDK/memA/ protein conserved region HeH PF12949.7 ORX48303.1 - 0.06 13.1 0.3 0.19 11.5 0.3 1.8 1 1 0 1 1 1 0 HeH/LEM domain Inositol_P PF00459.25 ORX48304.1 - 3.4e-65 220.3 0.2 3.7e-65 220.1 0.2 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family GPI-anchored PF10342.9 ORX48305.1 - 0.089 13.6 0.1 0.15 12.8 0.1 1.4 1 0 0 1 1 1 0 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SOG2 PF10428.9 ORX48306.1 - 0.0048 16.2 19.2 0.0058 15.9 19.2 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein SPX PF03105.19 ORX48306.1 - 5.9 6.7 18.5 9 6.1 18.5 1.3 1 0 0 1 1 1 0 SPX domain SPX PF03105.19 ORX48307.1 - 4.4e-07 30.2 4.3 4.7e-07 30.1 4.3 1.1 1 0 0 1 1 1 1 SPX domain DUF4283 PF14111.6 ORX48307.1 - 0.081 12.4 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) Polysacc_deac_1 PF01522.21 ORX48308.1 - 3.9e-13 49.4 0.1 7e-13 48.6 0.1 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase PAP1 PF08601.10 ORX48309.1 - 1.5 8.4 8.4 1.9 8.1 8.4 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Amidohydro_2 PF04909.14 ORX48311.1 - 3.2e-07 30.4 0.0 4.5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.20 ORX48311.1 - 2.7e-05 23.7 0.1 4.1e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Amidohydrolase family YndJ PF14158.6 ORX48313.1 - 0.049 13.0 1.7 0.072 12.4 0.1 1.9 2 1 0 2 2 2 0 YndJ-like protein APH PF01636.23 ORX48314.1 - 1.6e-43 149.4 0.0 2.1e-43 149.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX48314.1 - 1.5e-07 31.1 0.1 4.4e-07 29.5 0.1 1.8 1 1 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ORX48314.1 - 5.1e-05 22.9 0.0 7.9e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 ORX48314.1 - 0.0012 18.1 0.0 0.2 10.8 0.0 2.3 1 1 1 2 2 2 2 Fructosamine kinase Pkinase PF00069.25 ORX48314.1 - 0.0019 17.6 0.0 0.65 9.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain RIO1 PF01163.22 ORX48314.1 - 0.0072 16.0 0.0 0.46 10.1 0.0 2.2 2 0 0 2 2 2 1 RIO1 family DUF1679 PF07914.11 ORX48314.1 - 0.072 11.9 0.1 0.73 8.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1679) CGI-121 PF08617.10 ORX48315.1 - 6.9e-46 156.3 0.0 7.7e-46 156.2 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 La PF05383.17 ORX48315.1 - 0.098 12.7 0.0 0.33 11.0 0.0 1.8 2 0 0 2 2 2 0 La domain zf-C2H2 PF00096.26 ORX48316.1 - 1.3e-17 63.2 32.9 1.6e-05 25.1 1.4 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX48316.1 - 7.2e-16 57.8 31.7 2.7e-07 30.7 2.5 4.8 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX48316.1 - 1.3e-08 35.0 30.2 0.0039 17.9 5.2 4.7 4 1 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX48316.1 - 0.001 19.3 5.7 2 8.8 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX48316.1 - 0.0064 17.1 9.6 0.013 16.1 0.4 3.1 3 0 0 3 3 3 1 FOXP coiled-coil domain zf-met PF12874.7 ORX48316.1 - 2.2 8.8 11.1 7.5 7.1 0.1 4.0 4 1 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX48316.1 - 3.2 7.6 16.7 0.25 11.1 1.2 3.7 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-C2H2_3rep PF18868.1 ORX48316.1 - 4.8 7.9 9.3 3.4 8.4 0.1 3.2 2 1 2 4 4 4 0 Zinc finger C2H2-type, 3 repeats CcdA PF07362.12 ORX48319.1 - 0.83 10.1 9.5 0.31 11.5 5.5 2.1 2 1 0 2 2 2 0 Post-segregation antitoxin CcdA DivIC PF04977.15 ORX48319.1 - 3.8 7.3 20.1 0.64 9.8 0.5 2.2 2 0 0 2 2 2 0 Septum formation initiator HAD PF12710.7 ORX48320.1 - 1.7e-19 71.0 0.1 2e-19 70.7 0.1 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX48320.1 - 0.055 13.8 0.0 0.099 12.9 0.0 1.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 ORX48320.1 - 0.085 12.4 0.0 0.52 9.8 0.0 2.1 2 1 1 3 3 3 0 Pyrimidine 5'-nucleotidase (UMPH-1) Ribosomal_L7Ae PF01248.26 ORX48320.1 - 0.14 11.9 0.1 0.47 10.2 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF4350 PF14258.6 ORX48320.1 - 0.19 12.2 0.0 1.2 9.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) zf-CpG_bind_C PF12269.8 ORX48321.1 - 1.1e-08 35.2 1.5 1.1e-05 25.3 0.2 2.4 2 0 0 2 2 2 2 CpG binding protein zinc finger C terminal domain PHD PF00628.29 ORX48321.1 - 2e-08 34.0 13.4 6e-08 32.5 13.4 1.9 1 0 0 1 1 1 1 PHD-finger DUF4451 PF14616.6 ORX48321.1 - 0.033 14.4 4.1 0.15 12.3 1.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4451) Ribosomal_60s PF00428.19 ORX48322.1 - 2.3e-26 92.2 6.6 2.7e-26 92.0 6.6 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 ORX48322.1 - 0.034 14.6 2.0 0.059 13.8 0.3 1.9 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) CRAL_TRIO PF00650.20 ORX48323.1 - 3.7e-34 117.8 0.0 5.1e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ORX48323.1 - 0.00044 20.4 0.0 0.0007 19.8 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX48323.1 - 0.0013 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain adh_short_C2 PF13561.6 ORX48324.1 - 3.5e-47 160.9 0.0 4.8e-47 160.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX48324.1 - 7.6e-45 152.8 0.0 9.3e-45 152.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX48324.1 - 1.1e-07 31.9 0.0 2.1e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX48324.1 - 0.17 11.2 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Peptidase_S8 PF00082.22 ORX48325.1 - 7.5e-41 140.3 0.1 3.1e-40 138.3 0.1 1.9 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 ORX48325.1 - 1e-16 61.6 3.0 2.1e-16 60.6 3.0 1.5 1 0 0 1 1 1 1 Fn3-like domain PA PF02225.22 ORX48325.1 - 1e-11 44.7 0.6 1e-11 44.7 0.6 2.4 2 0 0 2 2 2 1 PA domain Motile_Sperm PF00635.26 ORX48325.1 - 0.0073 16.1 1.6 0.028 14.2 0.4 2.2 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Y_Y_Y PF07495.13 ORX48325.1 - 0.015 15.3 0.0 0.042 13.8 0.0 1.8 1 0 0 1 1 1 0 Y_Y_Y domain DUF916 PF06030.12 ORX48325.1 - 0.052 13.6 0.5 0.12 12.4 0.5 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF916) Pro-rich PF15240.6 ORX48326.1 - 2.7 8.2 27.6 11 6.2 27.6 1.8 1 1 0 1 1 1 0 Proline-rich E1-E2_ATPase PF00122.20 ORX48327.1 - 9.6e-29 100.2 0.1 9.6e-29 100.2 0.1 2.0 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ORX48327.1 - 6.1e-11 43.0 0.1 1.1e-05 25.8 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX48327.1 - 0.00056 19.6 0.1 0.0017 18.0 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX48327.1 - 0.014 15.4 0.0 0.032 14.3 0.0 1.6 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX48327.1 - 0.14 11.9 0.1 0.41 10.4 0.1 1.7 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase XFP_C PF09363.10 ORX48474.1 - 0.053 13.0 0.0 0.055 12.9 0.0 1.0 1 0 0 1 1 1 0 XFP C-terminal domain Dynactin PF12455.8 ORX48475.1 - 6e-81 271.8 8.2 6e-81 271.8 8.2 4.4 4 1 1 5 5 5 2 Dynein associated protein CAP_GLY PF01302.25 ORX48475.1 - 2.6e-24 85.0 0.6 4.5e-24 84.3 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain Rad51 PF08423.11 ORX48476.1 - 1.8e-18 66.7 0.0 2.2e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 ORX48476.1 - 0.00031 20.4 0.0 0.00052 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ORX48476.1 - 0.0017 17.8 0.2 0.0022 17.4 0.2 1.2 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain CALM_bind PF16025.5 ORX48479.1 - 0.2 12.1 6.1 0.48 10.9 6.1 1.6 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding DNA_pol_phi PF04931.13 ORX48479.1 - 9.3 4.2 10.4 13 3.7 10.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi Mito_carr PF00153.27 ORX48480.1 - 3.9e-28 97.2 7.4 2.1e-12 46.8 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX48480.1 - 0.0052 16.0 1.0 0.016 14.4 0.1 2.1 2 1 0 2 2 2 1 Gammaproteobacterial serine protease WD40 PF00400.32 ORX48481.1 - 1.1e-22 79.8 4.2 3.1e-10 40.4 0.0 5.3 7 0 0 7 7 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48481.1 - 6e-10 39.3 0.1 0.0021 18.3 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX48481.1 - 8.4e-06 25.8 0.0 0.054 13.4 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A bZIP_1 PF00170.21 ORX48481.1 - 0.0015 18.5 0.9 0.0038 17.3 0.9 1.6 1 0 0 1 1 1 1 bZIP transcription factor Nup160 PF11715.8 ORX48481.1 - 0.0025 16.6 0.5 0.95 8.0 0.0 2.7 2 1 1 3 3 3 2 Nucleoporin Nup120/160 YabA PF06156.13 ORX48481.1 - 0.0067 17.1 0.6 0.18 12.5 0.7 2.6 2 1 0 2 2 2 1 Initiation control protein YabA Cnn_1N PF07989.11 ORX48481.1 - 0.013 15.6 0.4 0.013 15.6 0.4 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Uds1 PF15456.6 ORX48481.1 - 0.023 14.9 0.5 0.043 14.0 0.5 1.5 1 0 0 1 1 1 0 Up-regulated During Septation Csm1_N PF18504.1 ORX48481.1 - 0.056 13.8 0.7 0.056 13.8 0.7 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain Ge1_WD40 PF16529.5 ORX48481.1 - 0.074 12.0 0.1 0.38 9.6 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX48481.1 - 0.085 12.2 0.0 7.2 5.8 0.0 2.9 2 1 0 3 3 3 0 WD40-like domain DUF4180 PF13788.6 ORX48481.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4180) Shugoshin_N PF07558.11 ORX48481.1 - 0.28 11.1 1.2 0.54 10.2 1.2 1.4 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region FlxA PF14282.6 ORX48481.1 - 0.38 10.8 5.5 3.6 7.6 0.2 2.3 2 0 0 2 2 2 0 FlxA-like protein DivIC PF04977.15 ORX48481.1 - 0.41 10.4 4.5 0.12 12.1 1.3 1.7 2 0 0 2 2 2 0 Septum formation initiator SlyX PF04102.12 ORX48481.1 - 0.72 10.5 2.7 1.1 9.9 0.3 2.1 2 0 0 2 2 2 0 SlyX ZapB PF06005.12 ORX48481.1 - 1.1 9.8 4.5 4.9 7.7 4.4 2.0 1 1 0 1 1 1 0 Cell division protein ZapB Cyclin PF08613.11 ORX48482.1 - 7.4e-36 123.9 0.3 2e-35 122.6 0.3 1.7 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX48482.1 - 0.00044 20.0 0.1 0.0012 18.5 0.0 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sec10 PF07393.11 ORX48483.1 - 3.8e-112 376.0 9.3 5e-112 375.6 9.3 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 ORX48483.1 - 4.4e-08 32.9 0.9 1.1e-07 31.7 0.9 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX48483.1 - 1.5e-07 31.1 0.7 3.7e-07 29.9 0.7 1.6 1 0 0 1 1 1 1 F-box domain AnmK PF03702.14 ORX48483.1 - 0.069 12.2 0.0 0.13 11.3 0.0 1.4 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase FliJ PF02050.16 ORX48483.1 - 1.4 9.1 4.5 20 5.4 0.3 3.2 3 0 0 3 3 3 0 Flagellar FliJ protein LssY_C PF14067.6 ORX48484.1 - 0.047 13.2 0.1 0.056 13.0 0.1 1.1 1 0 0 1 1 1 0 LssY C-terminus hGDE_N PF14699.6 ORX48484.1 - 0.061 13.5 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain from the human glycogen debranching enzyme GntR PF00392.21 ORX48487.1 - 0.13 11.9 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family rRNA_proc-arch PF13234.6 ORX48488.1 - 8.2e-76 255.5 0.5 1.6e-75 254.6 0.1 1.7 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 ORX48488.1 - 6e-61 204.9 0.3 1.5e-60 203.6 0.3 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 ORX48488.1 - 9.6e-19 67.8 0.1 3.7e-18 65.9 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX48488.1 - 5.4e-08 33.2 0.0 4.7e-07 30.1 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX48488.1 - 3.6e-05 23.8 0.0 0.00013 22.0 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 ORX48488.1 - 0.00068 18.8 0.2 0.0024 17.0 0.0 2.0 2 0 0 2 2 2 1 Type II/IV secretion system protein Trehalase PF01204.18 ORX48489.1 - 2.6e-175 584.1 0.7 3.5e-175 583.7 0.7 1.2 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 ORX48489.1 - 3e-13 49.2 0.2 5.3e-13 48.4 0.2 1.4 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain zf-CRD PF17979.1 ORX48490.1 - 0.11 12.6 0.8 1.7 8.8 0.8 2.0 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions MFS_1 PF07690.16 ORX48491.1 - 5.7e-42 143.9 26.6 8.2e-42 143.4 26.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF443 PF04276.12 ORX48491.1 - 0.066 13.0 1.0 0.42 10.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF443) DUF1616 PF07760.11 ORX48491.1 - 0.17 11.3 0.6 0.67 9.3 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) UPF0060 PF02694.15 ORX48491.1 - 0.99 9.7 10.5 0.086 13.1 0.9 3.3 3 0 0 3 3 3 0 Uncharacterised BCR, YnfA/UPF0060 family RNase_H2-Ydr279 PF09468.10 ORX48492.1 - 3.6e-11 43.5 0.1 9.5e-11 42.1 0.0 1.6 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 ORX48492.1 - 2.6e-08 34.0 0.0 6.4e-08 32.7 0.0 1.7 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain FYVE PF01363.21 ORX48493.1 - 9.1e-21 73.8 5.3 9.1e-21 73.8 5.3 2.3 2 0 0 2 2 2 1 FYVE zinc finger Arm PF00514.23 ORX48493.1 - 0.00093 19.2 8.9 4.3 7.5 0.0 6.3 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat FYVE_2 PF02318.16 ORX48493.1 - 0.054 13.7 3.6 0.23 11.7 3.6 2.1 1 0 0 1 1 1 0 FYVE-type zinc finger PilJ_C PF18223.1 ORX48493.1 - 0.13 12.7 0.1 0.9 10.1 0.0 2.2 2 0 0 2 2 2 0 Pili PilJ C-terminal domain FEZ PF07763.13 ORX48493.1 - 0.14 11.9 2.1 0.35 10.6 2.1 1.6 1 0 0 1 1 1 0 FEZ-like protein IBR PF01485.21 ORX48493.1 - 0.14 12.4 6.5 0.52 10.6 6.5 2.0 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DZR PF12773.7 ORX48493.1 - 1.5 8.9 8.2 1.1e+02 2.9 8.2 2.7 1 1 0 1 1 1 0 Double zinc ribbon zinc-ribbons_6 PF07191.12 ORX48493.1 - 7.7 6.6 11.0 2.7e+02 1.7 0.0 3.8 3 1 0 3 3 3 0 zinc-ribbons Ferric_reduct PF01794.19 ORX48494.1 - 3.2e-17 62.8 13.0 3.2e-17 62.8 13.0 2.6 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ORX48494.1 - 9.7e-10 38.8 0.1 4e-06 27.0 0.0 2.2 1 1 1 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ORX48494.1 - 0.0013 18.8 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 ORX48494.1 - 0.12 13.0 0.0 0.36 11.5 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain DUF374 PF04028.13 ORX48494.1 - 0.15 11.6 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF374) Methyltr_RsmB-F PF01189.17 ORX48495.1 - 6.4e-32 110.8 0.0 1.2e-31 109.9 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 ORX48495.1 - 0.00019 22.1 0.1 0.0059 17.3 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX48495.1 - 0.0078 15.6 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX48495.1 - 0.017 15.2 0.0 0.03 14.4 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 ORX48495.1 - 0.027 14.3 0.1 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain DUF1512 PF07431.12 ORX48495.1 - 0.033 13.2 0.1 0.068 12.2 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1512) O-FucT PF10250.9 ORX48498.1 - 2e-10 40.9 0.0 0.00016 21.5 0.1 2.9 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase RabGAP-TBC PF00566.18 ORX48501.1 - 1.2e-42 146.0 7.0 2.8e-42 144.8 7.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 ORX48501.1 - 4.9e-11 42.4 0.2 7.1e-10 38.6 0.3 2.3 2 0 0 2 2 2 1 Rab-binding domain (RBD) Reticulon PF02453.17 ORX48502.1 - 5.1e-26 91.5 5.5 6e-26 91.3 5.5 1.1 1 0 0 1 1 1 1 Reticulon Sec7_N PF12783.7 ORX48503.1 - 0.069 13.1 0.0 0.11 12.4 0.0 1.4 1 1 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Reprolysin_5 PF13688.6 ORX48505.1 - 6e-39 134.2 5.6 6e-39 134.2 5.6 1.9 2 0 0 2 2 2 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 ORX48505.1 - 3.1e-38 131.6 1.5 6.2e-38 130.7 1.5 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ORX48505.1 - 2.2e-34 118.9 4.8 2.2e-34 118.9 2.9 2.0 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ORX48505.1 - 3.9e-15 56.4 22.3 3.9e-15 56.4 22.3 3.6 3 0 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 ORX48505.1 - 2e-12 47.7 2.5 1e-11 45.4 0.0 3.1 3 0 0 3 3 3 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 ORX48505.1 - 2e-05 24.9 0.0 3.9e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Reprolysin family propeptide ADAM_CR_2 PF17771.1 ORX48505.1 - 0.00019 21.8 7.0 0.00019 21.8 7.0 4.1 2 1 2 4 4 4 1 ADAM cysteine-rich domain Reprolysin PF01421.19 ORX48505.1 - 0.00056 19.9 6.9 0.0012 18.8 5.1 2.4 2 1 0 2 2 2 1 Reprolysin (M12B) family zinc metalloprotease LSM PF01423.22 ORX48506.1 - 8.6e-21 73.4 0.0 9.8e-21 73.2 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX48506.1 - 0.0066 16.6 0.0 0.0072 16.5 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain MMS22L_C PF14911.6 ORX48506.1 - 0.11 11.5 0.0 0.12 11.4 0.0 1.0 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal LSM14 PF12701.7 ORX48506.1 - 0.12 12.4 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Scd6-like Sm domain Alpha_L_fucos PF01120.17 ORX48507.1 - 1e-91 308.0 5.8 1.2e-91 307.8 5.8 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 ORX48507.1 - 0.24 11.6 1.8 0.36 11.0 0.1 2.4 2 1 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 Vma12 PF11712.8 ORX48508.1 - 1.9e-28 99.3 0.0 2.4e-28 98.9 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DnaG_DnaB_bind PF08278.11 ORX48508.1 - 0.015 15.9 0.2 0.027 15.1 0.2 1.5 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding DUF2512 PF10710.9 ORX48508.1 - 0.037 13.7 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2512) BRK PF07533.16 ORX48508.1 - 0.095 12.3 1.9 0.21 11.2 0.1 2.2 2 0 0 2 2 2 0 BRK domain FtsJ PF01728.19 ORX48509.1 - 8.1e-30 104.2 0.0 1.2e-29 103.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Pro_isomerase PF00160.21 ORX48510.1 - 5.7e-49 166.4 0.1 6.6e-49 166.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Solute_trans_a PF03619.16 ORX48511.1 - 6.9e-11 42.2 0.8 7.6e-11 42.0 0.8 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Saf_2TM PF18303.1 ORX48511.1 - 0.051 13.2 0.0 0.057 13.0 0.0 1.0 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain ResB PF05140.14 ORX48511.1 - 0.064 12.0 0.0 0.066 11.9 0.0 1.1 1 0 0 1 1 1 0 ResB-like family Phage_holin_2_4 PF16082.5 ORX48511.1 - 0.12 12.1 0.1 0.14 12.0 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Solute_trans_a PF03619.16 ORX48512.1 - 1.4e-54 185.4 6.7 1.8e-54 185.1 6.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF1201 PF06716.11 ORX48512.1 - 0.78 9.8 6.2 0.37 10.8 2.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Asp PF00026.23 ORX48513.1 - 2e-31 109.6 1.2 2.5e-31 109.3 1.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease PC-Esterase PF13839.6 ORX48514.1 - 4.6e-27 95.5 0.0 1e-26 94.4 0.0 1.5 1 1 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p PMR5N PF14416.6 ORX48514.1 - 0.47 10.8 4.2 1.9 8.9 4.2 2.1 1 1 0 1 1 1 0 PMR5 N terminal Domain Abhydrolase_1 PF00561.20 ORX48515.1 - 1.8e-26 93.4 0.0 7.3e-25 88.1 0.0 2.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX48515.1 - 1.1e-18 68.7 0.1 1.1e-18 68.7 0.1 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX48515.1 - 2.8e-18 66.0 0.0 5.1e-15 55.4 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 ORX48515.1 - 9.7e-07 28.8 0.0 0.0031 17.4 0.0 3.5 3 1 1 4 4 4 2 Serine hydrolase Esterase PF00756.20 ORX48515.1 - 1.2e-05 25.1 0.0 4.1e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 ORX48515.1 - 1.2e-05 25.3 0.0 0.09 12.6 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Ndr PF03096.14 ORX48515.1 - 2.1e-05 23.4 0.0 0.00079 18.2 0.0 2.2 2 0 0 2 2 2 1 Ndr family UPF0227 PF05728.12 ORX48515.1 - 0.0018 18.2 0.0 0.0053 16.7 0.0 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) LIDHydrolase PF10230.9 ORX48515.1 - 0.0069 16.0 0.0 0.025 14.2 0.0 1.9 3 0 0 3 3 3 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 ORX48515.1 - 0.079 12.8 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_5 PF12695.7 ORX48515.1 - 0.12 12.2 0.0 1.5 8.6 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Rax2 PF12768.7 ORX48519.1 - 0.097 12.1 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity PCM1_C PF15717.5 ORX48519.1 - 1 8.0 2.9 1.5 7.4 2.9 1.2 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Macoilin PF09726.9 ORX48519.1 - 9.3 4.7 9.1 11 4.4 9.1 1.3 1 0 0 1 1 1 0 Macoilin family COX5B PF01215.19 ORX48520.1 - 7.8e-44 148.5 0.0 8.4e-44 148.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 ORX48520.1 - 0.0011 19.0 0.2 0.0017 18.4 0.2 1.3 1 0 0 1 1 1 1 Zinc-finger domain zf-C4_Topoisom PF01396.19 ORX48520.1 - 0.0046 16.7 0.4 1 9.2 0.0 2.2 2 0 0 2 2 2 2 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_5 PF13719.6 ORX48520.1 - 0.048 13.4 0.3 0.087 12.6 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain COG6 PF06419.11 ORX48520.1 - 0.11 10.6 0.0 0.15 10.3 0.0 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Ras PF00071.22 ORX48521.1 - 3.2e-51 173.1 0.1 3.9e-51 172.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX48521.1 - 3.5e-37 127.3 0.2 4.7e-37 126.9 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX48521.1 - 3.2e-15 56.0 0.1 3.7e-15 55.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX48521.1 - 5.7e-09 35.7 0.0 7.2e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX48521.1 - 1.7e-06 28.1 0.0 2.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX48521.1 - 8.4e-05 22.1 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 ORX48521.1 - 0.00094 19.2 0.0 0.0013 18.7 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ORX48521.1 - 0.0038 17.6 0.0 0.0063 16.9 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_5 PF07728.14 ORX48521.1 - 0.0046 17.0 0.4 0.0096 15.9 0.1 1.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 ORX48521.1 - 0.0066 16.3 0.8 0.099 12.4 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ORX48521.1 - 0.0076 15.8 0.0 0.025 14.1 0.0 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain YwhD PF08741.10 ORX48521.1 - 0.0081 15.9 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 YwhD family RsgA_GTPase PF03193.16 ORX48521.1 - 0.0088 16.0 0.9 0.32 10.9 0.3 2.5 1 1 2 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 ORX48521.1 - 0.024 14.4 0.0 0.35 10.6 0.0 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ORX48521.1 - 0.043 13.7 0.4 0.11 12.5 0.4 1.7 1 1 0 1 1 1 0 NTPase AAA_14 PF13173.6 ORX48521.1 - 0.048 13.7 0.2 0.23 11.5 0.2 2.3 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ORX48521.1 - 0.049 13.2 0.3 3.2 7.3 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.6 ORX48521.1 - 0.076 13.3 0.4 0.66 10.2 0.4 2.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX48521.1 - 0.085 12.4 0.2 0.15 11.6 0.2 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ORX48521.1 - 0.12 12.9 0.1 0.23 12.0 0.1 1.5 1 1 0 1 1 1 0 ABC transporter APG12 PF04110.13 ORX48521.1 - 0.16 12.4 0.0 0.87 10.0 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 FH2 PF02181.23 ORX48522.1 - 3e-88 296.5 1.1 3e-88 296.5 1.1 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ORX48522.1 - 5.4e-06 26.1 0.1 5.4e-06 26.1 0.1 3.1 4 0 0 4 4 4 1 Diaphanous FH3 Domain zf-C4H2 PF10146.9 ORX48522.1 - 0.00052 20.4 5.0 0.059 13.7 0.1 3.4 3 0 0 3 3 3 2 Zinc finger-containing protein Herpes_UL6 PF01763.16 ORX48522.1 - 0.0013 17.3 0.2 0.0031 16.1 0.2 1.5 1 0 0 1 1 1 1 Herpesvirus UL6 like DUF4337 PF14235.6 ORX48522.1 - 0.0019 18.3 1.8 0.0019 18.3 1.8 2.0 2 0 0 2 2 1 1 Domain of unknown function (DUF4337) DUF812 PF05667.11 ORX48522.1 - 0.0045 16.0 0.3 0.0045 16.0 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF812) DUF948 PF06103.11 ORX48522.1 - 0.011 16.0 4.2 2.9 8.2 0.1 3.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Rab5-bind PF09311.11 ORX48522.1 - 0.068 12.6 14.8 0.87 8.9 0.9 3.3 3 0 0 3 3 3 0 Rabaptin-like protein Laminin_II PF06009.12 ORX48522.1 - 0.071 13.1 5.8 1 9.4 0.0 2.7 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 ORX48522.1 - 0.14 11.0 10.3 0.18 10.7 2.7 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein CCDC53 PF10152.9 ORX48522.1 - 0.3 11.5 6.9 2.8 8.3 0.7 3.6 2 2 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4618 PF15397.6 ORX48522.1 - 0.32 10.4 8.3 0.11 11.9 3.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4618) Cep57_CLD_2 PF14197.6 ORX48522.1 - 0.37 10.9 5.4 1.5 9.0 5.4 2.0 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 ZapB PF06005.12 ORX48522.1 - 0.98 9.9 11.3 0.086 13.3 4.5 2.6 2 0 0 2 2 2 0 Cell division protein ZapB CENP-F_leu_zip PF10473.9 ORX48522.1 - 1.8 8.6 18.3 0.12 12.4 6.9 3.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SKA1 PF07160.12 ORX48522.1 - 2.2 8.0 6.9 0.4 10.5 0.3 2.8 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 1 XhlA PF10779.9 ORX48522.1 - 9.3 6.5 8.7 3.3 8.0 0.1 3.2 3 0 0 3 3 2 0 Haemolysin XhlA Rad9 PF04139.13 ORX48523.1 - 4.6e-19 68.9 0.0 7.4e-19 68.2 0.0 1.2 1 0 0 1 1 1 1 Rad9 Nucleo_P87 PF07267.11 ORX48523.1 - 0.045 12.6 2.2 0.051 12.4 2.2 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 AMPK1_CBM PF16561.5 ORX48524.1 - 8.7e-23 80.4 1.3 1.1e-22 80.0 1.3 1.1 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM_48 PF02922.18 ORX48524.1 - 0.00012 22.3 0.1 0.00016 22.0 0.1 1.1 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 ORX48524.1 - 0.026 15.1 2.1 0.044 14.4 2.1 1.5 1 1 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) RhoGAP PF00620.27 ORX48526.1 - 0.046 13.6 0.9 1 9.2 0.3 2.0 2 0 0 2 2 2 0 RhoGAP domain eIF3g PF12353.8 ORX48526.1 - 2.1 8.8 10.2 5.6 7.4 10.1 1.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G ETF_QO PF05187.13 ORX48529.1 - 9.1e-49 163.9 0.0 1.5e-48 163.2 0.0 1.4 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S FAD_binding_2 PF00890.24 ORX48529.1 - 5.7e-09 35.6 0.9 5.1e-05 22.5 2.5 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ORX48529.1 - 2.9e-08 33.7 0.0 0.00034 20.3 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Thi4 PF01946.17 ORX48529.1 - 1.1e-06 28.1 0.0 0.00075 18.8 0.2 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 ORX48529.1 - 1.7e-06 28.1 0.0 1.1e-05 25.6 0.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX48529.1 - 2.4e-06 27.0 0.4 5.7e-06 25.8 0.4 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX48529.1 - 1.4e-05 25.6 0.6 0.38 11.3 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX48529.1 - 1.7e-05 24.4 0.0 2.5e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ORX48529.1 - 4.2e-05 22.6 0.7 0.0042 16.0 1.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_9 PF13454.6 ORX48529.1 - 7.4e-05 22.8 0.6 0.00043 20.3 0.6 2.1 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ORX48529.1 - 0.00013 20.9 1.3 0.00021 20.1 1.3 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 ORX48529.1 - 0.00014 21.2 0.3 0.00022 20.6 0.3 1.4 1 1 0 1 1 1 1 FAD binding domain Fer4_7 PF12838.7 ORX48529.1 - 0.00035 21.1 0.6 0.0009 19.8 0.6 1.7 1 0 0 1 1 1 1 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 ORX48529.1 - 0.0012 17.9 0.4 0.0018 17.4 0.4 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ORX48529.1 - 0.0025 17.1 0.6 0.0039 16.5 0.6 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX48529.1 - 0.065 12.3 1.1 0.098 11.7 1.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 ORX48529.1 - 0.1 11.9 0.2 0.17 11.1 0.2 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_2 PF12797.7 ORX48529.1 - 0.17 12.0 0.6 0.44 10.7 0.6 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain DNA_pol_A_exo1 PF01612.20 ORX48530.1 - 0.0061 16.3 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 3'-5' exonuclease Phage_min_cap2 PF06152.11 ORX48530.1 - 0.088 11.7 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Phage minor capsid protein 2 adh_short_C2 PF13561.6 ORX48530.1 - 0.1 12.1 0.1 0.43 10.1 0.0 1.8 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase Lipase_GDSL_2 PF13472.6 ORX48531.1 - 0.0045 17.4 0.0 0.009 16.4 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF3951 PF13131.6 ORX48531.1 - 1.5 9.1 0.0 1.5 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3951) LSM PF01423.22 ORX48532.1 - 3.1e-19 68.4 0.4 3.5e-19 68.3 0.4 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX48532.1 - 2.4e-05 24.4 0.0 2.8e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 ORX48532.1 - 0.031 14.4 0.1 0.033 14.3 0.1 1.1 1 0 0 1 1 1 0 Scd6-like Sm domain Laminin_II PF06009.12 ORX48533.1 - 0.017 15.2 1.5 0.031 14.3 1.5 1.4 1 0 0 1 1 1 0 Laminin Domain II TMF_DNA_bd PF12329.8 ORX48533.1 - 0.026 14.5 4.1 1.6 8.7 0.6 2.8 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Surfac_D-trimer PF09006.11 ORX48533.1 - 0.05 13.5 0.1 0.27 11.1 0.0 2.2 1 1 1 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation YPEB PF14620.6 ORX48533.1 - 0.073 12.4 1.6 0.16 11.3 1.6 1.5 1 1 0 1 1 1 0 YpeB sporulation DivIC PF04977.15 ORX48533.1 - 0.085 12.6 2.7 0.79 9.5 0.3 2.7 2 1 0 2 2 2 0 Septum formation initiator ABC_tran_CTD PF16326.5 ORX48533.1 - 0.28 11.5 3.0 0.36 11.1 0.5 2.2 2 0 0 2 2 2 0 ABC transporter C-terminal domain CENP-F_leu_zip PF10473.9 ORX48533.1 - 1.8 8.6 9.5 0.69 9.9 6.3 1.8 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FUSC PF04632.12 ORX48533.1 - 2 6.9 4.7 2.6 6.5 4.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family UQ_con PF00179.26 ORX48534.1 - 1.3e-47 161.0 0.0 1.9e-47 160.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX48534.1 - 0.00011 21.9 0.0 0.00015 21.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B SR-25 PF10500.9 ORX48534.1 - 0.0052 16.4 4.1 0.0071 16.0 4.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein RWD PF05773.22 ORX48534.1 - 0.021 15.1 0.0 0.026 14.8 0.0 1.4 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 ORX48534.1 - 0.044 13.6 0.0 0.093 12.6 0.0 1.5 1 0 0 1 1 1 0 UEV domain DUF3446 PF11928.8 ORX48534.1 - 2.1 8.7 11.8 25 5.3 8.7 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain F_bP_aldolase PF01116.20 ORX48535.1 - 3e-93 312.3 0.1 3.4e-93 312.2 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II CPSase_L_D2 PF02786.17 ORX48535.1 - 0.036 13.5 0.6 0.66 9.4 0.1 2.2 1 1 1 2 2 2 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Glyoxal_oxid_N PF07250.11 ORX48536.1 - 1.9e-57 194.2 0.0 1.6e-56 191.2 0.0 2.4 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 ORX48536.1 - 9.8e-23 80.3 0.0 1.8e-22 79.4 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_6 PF13964.6 ORX48536.1 - 0.00014 22.0 0.8 7 7.1 0.0 5.4 6 1 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ORX48536.1 - 0.0078 16.2 0.0 6.8 6.8 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX48536.1 - 0.013 15.5 0.0 3.6 7.7 0.0 4.2 5 1 0 5 5 5 0 Kelch motif Utp12 PF04003.12 ORX48537.1 - 2.4e-21 76.1 0.0 5.1e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40 PF00400.32 ORX48537.1 - 0.0005 20.8 0.6 1.2 10.1 0.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48537.1 - 0.0021 18.3 0.2 9.4 6.6 0.0 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PI3K_1B_p101 PF10486.9 ORX48537.1 - 0.014 13.2 7.4 0.029 12.2 0.2 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sugarporin_N PF11471.8 ORX48537.1 - 0.085 12.8 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PLDc PF00614.22 ORX48538.1 - 4.4e-17 61.5 0.8 2.6e-09 36.8 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX48538.1 - 6e-17 61.8 0.1 4.6e-06 26.6 0.0 3.3 3 0 0 3 3 3 3 PLD-like domain HAD PF12710.7 ORX48539.1 - 2.2e-10 41.3 0.0 3.4e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 ORX48539.1 - 0.057 12.8 0.0 7.6 5.8 0.0 2.2 2 0 0 2 2 2 0 Putative Phosphatase Ribosomal_L36e PF01158.18 ORX48540.1 - 1.7e-39 134.0 7.3 1.9e-39 133.8 7.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e DUF4131 PF13567.6 ORX48541.1 - 0.78 9.4 11.3 0.94 9.1 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Rav1p_C PF12234.8 ORX48543.1 - 1.6e-175 585.1 7.9 1.6e-175 585.1 7.9 1.7 2 0 0 2 2 2 1 RAVE protein 1 C terminal WD40 PF00400.32 ORX48543.1 - 0.016 16.1 2.0 11 7.0 0.0 5.7 6 0 0 6 6 6 0 WD domain, G-beta repeat TLD PF07534.16 ORX48544.1 - 3.8e-36 124.4 0.0 5e-36 124.0 0.0 1.2 1 0 0 1 1 1 1 TLD Cu-binding_MopE PF11617.8 ORX48544.1 - 0.063 13.5 0.5 0.13 12.5 0.5 1.5 1 0 0 1 1 1 0 Putative metal-binding motif Macoilin PF09726.9 ORX48545.1 - 0.76 8.3 9.8 0.8 8.2 9.8 1.0 1 0 0 1 1 1 0 Macoilin family TssO PF17561.2 ORX48546.1 - 0.0057 16.8 0.0 0.0087 16.2 0.0 1.2 1 0 0 1 1 1 1 Type VI secretion system, TssO Na_K-ATPase PF00287.18 ORX48546.1 - 0.16 11.1 1.9 0.28 10.3 0.2 2.0 2 0 0 2 2 2 0 Sodium / potassium ATPase beta chain Sec63 PF02889.16 ORX48547.1 - 2.7e-168 557.6 0.0 1.7e-91 305.9 0.0 2.5 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ORX48547.1 - 3.3e-50 170.3 6.1 1.5e-26 93.3 0.2 3.2 4 0 0 4 4 4 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 ORX48547.1 - 8.2e-38 129.0 0.0 2.9e-37 127.2 0.0 2.1 1 0 0 1 1 1 1 N-terminal helicase PWI domain ResIII PF04851.15 ORX48547.1 - 9.3e-29 100.6 0.1 1.4e-13 51.2 0.0 3.3 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX48547.1 - 7.2e-16 58.5 0.0 2.6e-08 34.2 0.0 4.0 2 2 0 2 2 2 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ORX48547.1 - 1.6e-08 34.9 0.3 0.0077 16.5 0.1 3.3 3 0 0 3 3 3 2 AAA domain DUF2075 PF09848.9 ORX48547.1 - 0.00066 19.0 0.0 0.18 11.0 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 ORX48547.1 - 0.022 13.8 0.0 2.7 7.0 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_7 PF12775.7 ORX48547.1 - 0.024 14.2 0.0 5 6.6 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 ORX48547.1 - 0.12 12.1 0.0 6.6 6.4 0.0 3.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AA_permease PF00324.21 ORX48548.1 - 1.1e-130 436.4 41.4 1.3e-130 436.3 41.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX48548.1 - 7.2e-45 153.6 46.4 8.7e-45 153.3 46.4 1.0 1 0 0 1 1 1 1 Amino acid permease ELL PF10390.9 ORX48549.1 - 5.2e-12 45.8 2.0 1.3e-11 44.5 2.0 1.7 1 0 0 1 1 1 1 RNA polymerase II elongation factor ELL Aminotran_1_2 PF00155.21 ORX48550.1 - 1.8e-20 73.5 0.0 5e-19 68.7 0.0 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II DPBB_1 PF03330.18 ORX48551.1 - 6e-06 26.5 0.1 1.6e-05 25.1 0.1 1.8 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX48551.1 - 0.0073 16.2 0.2 0.0088 15.9 0.2 1.3 1 0 0 1 1 1 1 Barwin family TRAM_2 PF18693.1 ORX48551.1 - 0.06 13.5 0.0 0.091 12.9 0.0 1.3 1 0 0 1 1 1 0 TRAM domain zf-CCCH PF00642.24 ORX48552.1 - 5.3e-20 70.8 18.7 7.1e-10 38.5 3.8 2.1 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX48552.1 - 6.4e-09 35.6 19.8 0.00014 21.8 3.8 2.2 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ORX48552.1 - 4.8e-07 29.4 16.3 0.00094 18.9 5.2 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX48552.1 - 0.00082 19.8 13.9 0.054 14.0 4.2 2.4 2 1 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ORX48552.1 - 0.14 12.9 12.6 1.2 9.8 2.9 2.1 1 1 1 2 2 2 0 Torus domain GMC_oxred_C PF05199.13 ORX48552.1 - 0.46 11.0 1.2 7.3 7.1 1.2 2.0 1 1 0 1 1 1 0 GMC oxidoreductase DUF745 PF05335.13 ORX48553.1 - 0.039 13.7 12.7 0.31 10.7 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF745) DUF948 PF06103.11 ORX48553.1 - 0.46 10.8 8.5 0.96 9.7 0.4 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Corona_S2 PF01601.16 ORX48553.1 - 0.71 8.3 2.9 5.5 5.4 0.4 2.0 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein NPV_P10 PF05531.12 ORX48553.1 - 1.2 9.6 8.5 2.5 8.6 1.0 2.7 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein V-SNARE_C PF12352.8 ORX48553.1 - 1.5 9.2 13.1 1.7 9.0 0.4 3.3 3 1 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus Laminin_II PF06009.12 ORX48553.1 - 2.7 8.0 10.7 9.4 6.3 1.2 2.5 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 ORX48553.1 - 3.7 7.6 10.4 5.5 7.1 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 ORX48553.1 - 5.2 6.3 13.5 0.9 8.8 1.3 2.2 2 0 0 2 2 2 0 FAM76 protein AAA_2 PF07724.14 ORX48554.1 - 5.2e-30 104.8 0.1 5.3e-19 69.0 0.0 2.7 1 1 1 2 2 2 2 AAA domain (Cdc48 subfamily) Ank_2 PF12796.7 ORX48554.1 - 3.9e-13 49.8 0.1 1.3e-06 28.9 0.0 3.0 3 0 0 3 3 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX48554.1 - 3.8e-12 46.5 0.3 0.00037 21.0 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX48554.1 - 2.8e-11 42.6 0.4 0.00019 21.6 0.0 3.5 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ORX48554.1 - 2.2e-10 40.5 0.4 0.00063 20.1 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat ClpB_D2-small PF10431.9 ORX48554.1 - 3.3e-10 39.9 0.0 3e-09 36.8 0.0 2.5 2 0 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein Ank_5 PF13857.6 ORX48554.1 - 4.6e-10 39.6 0.9 0.0014 18.9 0.2 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) AAA PF00004.29 ORX48554.1 - 3.4e-07 30.8 0.4 1.1e-06 29.1 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX48554.1 - 0.00052 20.3 0.0 0.0085 16.4 0.0 2.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ORX48554.1 - 0.00079 18.8 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Sigma54_activat PF00158.26 ORX48554.1 - 0.0014 18.4 0.0 0.0025 17.5 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain Torsin PF06309.11 ORX48554.1 - 0.0042 17.2 0.0 0.0088 16.1 0.0 1.5 1 0 0 1 1 1 1 Torsin AAA_18 PF13238.6 ORX48554.1 - 0.023 15.3 0.8 0.65 10.5 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 ORX48554.1 - 0.03 14.5 0.0 0.079 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX48554.1 - 0.031 14.7 0.0 0.15 12.5 0.0 2.2 2 1 0 2 2 1 0 AAA ATPase domain AAA_24 PF13479.6 ORX48554.1 - 0.032 14.0 0.0 0.13 11.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX48554.1 - 0.037 14.5 0.0 0.093 13.2 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Bac_DnaA PF00308.18 ORX48554.1 - 0.058 13.2 0.0 0.44 10.3 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein RNA_helicase PF00910.22 ORX48554.1 - 0.059 13.8 0.0 0.17 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 ORX48554.1 - 0.064 13.3 0.1 0.87 9.6 0.1 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 ORX48554.1 - 0.068 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 ORX48554.1 - 0.098 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Ribosomal_L36 PF00444.18 ORX48555.1 - 1.3e-18 66.9 10.6 1.6e-18 66.6 10.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L36 Aldo_ket_red PF00248.21 ORX48556.1 - 2.1e-45 155.2 0.3 4.2e-44 150.9 0.3 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1737 PF08410.10 ORX48556.1 - 0.013 15.4 0.1 5.4 7.0 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1737) Fungal_trans PF04082.18 ORX48557.1 - 3.3e-08 32.9 0.4 1.1e-07 31.1 0.3 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain Spc7 PF08317.11 ORX48557.1 - 0.14 11.0 4.8 0.31 9.9 4.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein SUIM_assoc PF16619.5 ORX48557.1 - 0.15 12.2 5.9 0.9 9.7 1.3 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Prenyltransf PF01255.19 ORX48558.1 - 1.4e-70 237.3 0.0 1.8e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase PPR_2 PF13041.6 ORX48559.1 - 8.9e-53 176.3 9.2 1.3e-10 41.3 0.4 13.5 11 3 5 16 16 16 9 PPR repeat family PPR PF01535.20 ORX48559.1 - 4.9e-38 126.7 9.4 0.00021 21.3 0.0 14.9 16 0 0 16 16 16 10 PPR repeat PPR_3 PF13812.6 ORX48559.1 - 2.5e-35 120.4 0.9 3.8e-06 26.9 0.1 7.4 5 2 1 6 6 6 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX48559.1 - 1.3e-29 103.2 0.0 2.8e-10 39.9 0.0 6.4 4 1 3 7 7 7 5 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX48559.1 - 2.9e-20 71.7 0.1 0.19 11.4 0.0 10.9 11 1 1 12 12 12 4 PPR repeat TPR_19 PF14559.6 ORX48559.1 - 8.5e-06 26.2 0.0 2.2 8.9 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ATP13 PF12921.7 ORX48559.1 - 0.019 14.8 0.2 8.2 6.3 0.0 4.2 4 0 0 4 4 4 0 Mitochondrial ATPase expression Coatomer_E PF04733.14 ORX48559.1 - 0.036 13.5 1.9 0.16 11.3 0.1 2.5 3 0 0 3 3 3 0 Coatomer epsilon subunit RPM2 PF08579.11 ORX48559.1 - 0.075 13.4 0.1 54 4.2 0.1 4.2 2 2 3 5 5 5 0 Mitochondrial ribonuclease P subunit (RPM2) TPR_8 PF13181.6 ORX48559.1 - 0.11 12.7 0.0 3.4 8.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat C_Hendra PF16821.5 ORX48559.1 - 0.12 12.2 3.2 1.5 8.7 1.2 2.5 2 0 0 2 2 2 0 C protein from hendra and measles viruses PGAP1 PF07819.13 ORX48560.1 - 2.1e-78 263.2 0.0 3e-78 262.7 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 ORX48560.1 - 0.00012 21.8 0.0 0.00028 20.6 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 ORX48560.1 - 0.0032 17.0 0.4 0.0064 16.0 0.4 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 ORX48560.1 - 0.0073 16.9 0.2 0.0073 16.9 0.2 2.7 3 1 0 3 3 3 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 ORX48560.1 - 0.015 15.1 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase LCAT PF02450.15 ORX48560.1 - 0.04 13.1 0.1 0.079 12.1 0.1 1.4 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 ORX48560.1 - 0.055 12.7 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF4231 PF14015.6 ORX48560.1 - 2.4 8.7 7.4 20 5.7 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) zf-MYND PF01753.18 ORX48561.1 - 2.2e-08 34.1 12.2 4e-08 33.2 12.2 1.4 1 0 0 1 1 1 1 MYND finger TPR_2 PF07719.17 ORX48561.1 - 3.1e-08 33.1 4.9 0.29 11.4 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX48561.1 - 8.9e-08 31.8 7.8 0.13 12.6 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX48561.1 - 3.2e-07 29.9 6.7 0.0022 17.7 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX48561.1 - 4.3e-05 23.7 0.1 0.24 11.7 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX48561.1 - 0.00055 20.4 1.1 38 5.2 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat PAD_M PF08527.10 ORX48561.1 - 0.0035 17.0 0.0 0.071 12.8 0.0 2.4 2 0 0 2 2 2 1 Protein-arginine deiminase (PAD) middle domain ANAPC3 PF12895.7 ORX48561.1 - 0.03 14.6 3.6 0.061 13.6 0.5 3.0 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DegV PF02645.16 ORX48561.1 - 0.082 12.2 0.3 0.53 9.6 0.0 2.2 2 2 1 3 3 3 0 Uncharacterised protein, DegV family COG1307 DUF5416 PF17437.2 ORX48561.1 - 0.16 11.7 1.6 0.54 10.0 0.1 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5416) DUF1525 PF07511.11 ORX48561.1 - 2.2 8.5 4.2 4.2 7.5 0.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1525) ABC_membrane_2 PF06472.15 ORX48562.1 - 1.8e-88 296.4 1.1 2.4e-88 296.0 1.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX48562.1 - 1.6e-16 61.1 0.0 4.3e-16 59.7 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX48562.1 - 0.00093 18.7 0.9 0.2 11.1 0.1 2.6 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX48562.1 - 0.002 18.0 0.3 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX48562.1 - 0.0072 16.9 0.0 0.019 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ORX48562.1 - 0.0073 16.0 0.0 0.017 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 ORX48562.1 - 0.036 14.0 0.1 0.89 9.4 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_16 PF13191.6 ORX48562.1 - 0.064 13.6 0.0 0.19 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain RhoGAP PF00620.27 ORX48563.1 - 2e-27 95.9 1.3 5.9e-27 94.4 0.1 2.4 2 2 1 3 3 3 1 RhoGAP domain FCH PF00611.23 ORX48563.1 - 0.013 15.8 1.9 0.027 14.7 0.2 2.3 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain PH PF00169.29 ORX48564.1 - 2.3e-09 37.7 0.3 5.1e-09 36.6 0.1 1.6 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ORX48564.1 - 0.0064 16.7 0.6 3 8.2 0.1 2.2 2 0 0 2 2 2 2 Pleckstrin homology domain PH_12 PF16457.5 ORX48564.1 - 2 9.0 5.8 46 4.5 3.6 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain AMPKBI PF04739.15 ORX48565.1 - 0.072 13.4 0.4 0.83 10.0 0.0 2.3 2 0 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interaction domain zf-RRN7 PF11781.8 ORX48565.1 - 0.44 10.3 1.8 3.4 7.4 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 OrfB_Zn_ribbon PF07282.11 ORX48565.1 - 1.8 8.5 7.0 0.25 11.3 0.3 2.5 2 1 0 3 3 3 0 Putative transposase DNA-binding domain SPRY PF00622.28 ORX48566.1 - 9.2e-23 80.6 0.5 1.8e-17 63.6 0.0 2.5 2 0 0 2 2 2 2 SPRY domain CLTH PF10607.9 ORX48566.1 - 6.6e-16 58.5 0.0 4.6e-15 55.8 0.0 2.1 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ORX48566.1 - 0.0014 18.5 0.2 0.007 16.3 0.1 2.2 2 0 0 2 2 2 1 LisH IMUP PF15761.5 ORX48566.1 - 0.19 12.4 3.7 0.43 11.3 3.7 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4909 PF16253.5 ORX48567.1 - 0.087 12.7 0.6 1.4 8.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4909) DnaJ PF00226.31 ORX48568.1 - 1.7e-18 66.5 1.3 2.4e-18 66.0 1.3 1.2 1 0 0 1 1 1 1 DnaJ domain zf-CSL PF05207.13 ORX48568.1 - 1.3e-15 56.9 2.5 2.1e-15 56.2 2.5 1.4 1 0 0 1 1 1 1 CSL zinc finger BRCT PF00533.26 ORX48569.1 - 2.3e-09 37.5 0.2 0.002 18.5 0.1 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ORX48569.1 - 2.2e-05 24.2 0.0 4.3e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 ORX48569.1 - 2.7e-05 24.5 0.1 0.33 11.4 0.0 2.5 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ORX48569.1 - 0.0013 18.6 0.2 0.56 10.2 0.1 2.4 2 0 0 2 2 2 2 twin BRCT domain ECH_2 PF16113.5 ORX48570.1 - 6.7e-95 318.4 0.0 9.1e-95 317.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ORX48570.1 - 9.7e-20 70.9 0.0 1.3e-15 57.4 0.0 2.2 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase zf-H2C2_2 PF13465.6 ORX48571.1 - 3.4e-25 87.3 15.9 5e-07 29.8 0.7 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 ORX48571.1 - 1.5e-24 85.0 27.7 4.1e-07 30.1 0.9 4.4 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX48571.1 - 2e-13 49.9 25.2 0.0012 19.5 1.8 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX48571.1 - 6.7e-06 26.2 2.0 0.95 9.8 0.1 4.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX48571.1 - 0.0007 19.9 6.5 11 6.6 0.1 4.5 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-LYAR PF08790.11 ORX48571.1 - 0.0035 17.2 12.8 0.21 11.5 1.6 4.4 4 1 0 4 4 4 2 LYAR-type C2HC zinc finger FOXP-CC PF16159.5 ORX48571.1 - 0.0051 17.4 8.6 6.8 7.4 0.1 4.1 2 1 2 4 4 4 2 FOXP coiled-coil domain Ogr_Delta PF04606.12 ORX48571.1 - 0.011 15.6 7.7 0.28 11.2 0.9 3.9 1 1 3 4 4 4 0 Ogr/Delta-like zinc finger zf-C2H2_11 PF16622.5 ORX48571.1 - 0.017 14.9 24.2 0.43 10.4 1.1 3.8 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-TRAF PF02176.18 ORX48571.1 - 0.027 15.2 10.5 0.12 13.1 0.4 2.9 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_aberr PF17017.5 ORX48571.1 - 0.23 11.6 8.2 12 6.0 0.2 3.6 1 1 3 4 4 4 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 ORX48571.1 - 5.7 7.1 18.5 13 5.9 2.0 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger Acyl-CoA_dh_1 PF00441.24 ORX48572.1 - 7.4e-29 100.9 0.5 1.2e-28 100.2 0.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX48572.1 - 9.9e-19 67.3 0.3 1.7e-18 66.6 0.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 ORX48572.1 - 1.2e-18 67.0 0.0 2.5e-18 66.0 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_N PF02771.16 ORX48572.1 - 1.1e-09 39.0 0.2 4e-09 37.1 0.2 2.0 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX48572.1 - 0.0033 17.7 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ORX48572.1 - 0.093 12.4 0.1 0.32 10.6 0.0 1.8 2 1 1 3 3 3 0 4-hydroxyphenylacetate 3-hydroxylase N terminal TRAPPC9-Trs120 PF08626.11 ORX48573.1 - 7.4e-221 735.8 0.0 2.3e-220 734.2 0.0 1.7 1 1 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit CRAL_TRIO PF00650.20 ORX48574.1 - 4e-17 62.4 0.4 6.9e-17 61.6 0.1 1.5 2 0 0 2 2 2 1 CRAL/TRIO domain GDP_Man_Dehyd PF16363.5 ORX48575.1 - 1.7e-56 192.0 0.0 2.2e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX48575.1 - 9e-52 175.9 0.0 1.3e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX48575.1 - 6.2e-17 61.5 0.0 1.4e-16 60.4 0.0 1.6 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ORX48575.1 - 1.1e-14 54.3 0.1 3.4e-14 52.7 0.1 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ORX48575.1 - 1.3e-09 38.2 0.0 2.1e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 KR domain adh_short PF00106.25 ORX48575.1 - 1.8e-09 37.3 0.0 3.2e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ORX48575.1 - 2.2e-07 31.0 0.0 3.8e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ORX48575.1 - 3.4e-07 29.6 0.0 4.8e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ORX48575.1 - 1.6e-06 27.5 0.0 0.00011 21.4 0.0 2.8 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ORX48575.1 - 0.00041 20.0 0.4 0.0017 17.9 0.3 1.9 2 0 0 2 2 2 1 NmrA-like family TrkA_N PF02254.18 ORX48575.1 - 0.0035 17.6 0.1 0.0072 16.6 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain adh_short_C2 PF13561.6 ORX48575.1 - 0.0062 16.1 0.0 0.011 15.2 0.0 1.4 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase UDPG_MGDP_dh_N PF03721.14 ORX48575.1 - 0.0079 15.8 0.1 0.021 14.4 0.1 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Cys_Met_Meta_PP PF01053.20 ORX48575.1 - 0.012 14.2 0.0 0.018 13.6 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DNApol_Exo PF18136.1 ORX48576.1 - 7e-95 317.4 0.0 3e-94 315.3 0.0 1.9 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 ORX48576.1 - 5.3e-50 170.5 0.0 2.2e-49 168.5 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 ORX48576.1 - 0.01 15.6 0.1 0.069 12.8 0.1 2.4 1 1 0 1 1 1 0 3'-5' exonuclease DUF1647 PF07801.11 ORX48577.1 - 1.4e-05 24.8 0.0 3.8e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1647) Methyltransf_25 PF13649.6 ORX48578.1 - 1e-13 51.8 0.0 1.9e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX48578.1 - 1.6e-12 47.5 0.0 2.3e-12 47.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX48578.1 - 9.9e-12 45.4 0.0 2.2e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX48578.1 - 2.4e-08 33.9 0.0 9.3e-08 32.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX48578.1 - 3e-07 30.1 0.0 4.6e-06 26.2 0.0 2.1 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 ORX48578.1 - 1.4e-06 28.9 0.0 2.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX48578.1 - 0.0002 21.3 0.0 0.0004 20.3 0.0 1.3 1 1 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 ORX48578.1 - 0.0012 17.5 0.0 0.0036 15.9 0.0 1.7 1 1 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Ubie_methyltran PF01209.18 ORX48578.1 - 0.016 14.5 0.0 0.035 13.4 0.0 1.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX48578.1 - 0.049 13.7 0.0 0.11 12.7 0.0 1.5 2 0 0 2 2 2 0 FtsJ-like methyltransferase MTS PF05175.14 ORX48578.1 - 0.17 11.4 0.0 0.36 10.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain hDGE_amylase PF14701.6 ORX48579.1 - 1.1e-159 532.2 0.0 1.7e-159 531.7 0.0 1.3 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 ORX48579.1 - 7.2e-122 407.0 0.0 2e-121 405.5 0.0 1.7 2 0 0 2 2 2 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 ORX48579.1 - 1.3e-73 247.8 0.0 2.1e-73 247.1 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 ORX48579.1 - 1.3e-09 38.1 0.0 5.5e-09 36.0 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain from the human glycogen debranching enzyme SBF_like PF13593.6 ORX48580.1 - 1.1e-81 274.5 21.1 1.4e-81 274.3 21.1 1.1 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 ORX48580.1 - 1.2e-08 34.9 12.8 1.2e-08 34.9 12.8 2.6 2 1 1 3 3 3 1 Sodium Bile acid symporter family SLAM PF06214.11 ORX48580.1 - 0.044 13.8 0.2 0.13 12.2 0.0 1.9 2 0 0 2 2 2 0 Signaling lymphocytic activation molecule (SLAM) protein OTU PF02338.19 ORX48581.1 - 3.3e-27 95.5 0.0 9e-27 94.1 0.0 1.7 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ORX48581.1 - 5.9e-05 22.6 0.0 0.00014 21.4 0.0 1.6 1 1 0 1 1 1 1 Peptidase C65 Otubain Herpes_TAF50 PF03326.13 ORX48582.1 - 0.0044 15.7 0.5 0.0051 15.5 0.5 1.0 1 0 0 1 1 1 1 Herpesvirus transcription activation factor (transactivator) AXH PF08517.12 ORX48582.1 - 0.039 14.5 0.1 0.049 14.2 0.1 1.2 1 0 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) WD40 PF00400.32 ORX48583.1 - 1.9e-40 136.0 21.0 9.1e-09 35.8 0.0 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48583.1 - 1.9e-16 60.1 2.1 0.0072 16.6 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX48583.1 - 6.3e-14 52.0 0.0 4.4e-08 32.8 0.0 2.7 2 1 0 2 2 2 2 WD40-like domain eIF2A PF08662.11 ORX48583.1 - 2e-10 40.8 0.1 0.00078 19.4 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX48583.1 - 0.00031 19.5 1.7 0.028 13.1 1.0 2.8 2 1 0 2 2 2 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX48583.1 - 0.00098 18.2 1.6 0.5 9.3 0.0 3.2 2 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein RAB3GAP2_N PF14655.6 ORX48583.1 - 0.021 14.1 1.1 0.74 9.0 0.5 2.3 1 1 1 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Benyvirus_P25 PF05744.11 ORX48583.1 - 0.046 13.0 0.1 0.072 12.4 0.1 1.3 1 0 0 1 1 1 0 Benyvirus P25/P26 protein Beta_propel PF09826.9 ORX48583.1 - 0.12 11.2 0.0 0.52 9.1 0.0 1.8 2 0 0 2 2 2 0 Beta propeller domain DUF1513 PF07433.11 ORX48583.1 - 0.87 8.6 3.1 20 4.1 0.2 3.4 1 1 2 4 4 4 0 Protein of unknown function (DUF1513) Gp_dh_C PF02800.20 ORX48584.1 - 4.3e-70 234.4 0.0 5.9e-70 233.9 0.0 1.2 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ORX48584.1 - 2.7e-41 140.0 0.1 5.5e-41 139.0 0.1 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX48584.1 - 0.017 15.2 0.3 0.068 13.3 0.1 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus ADH_zinc_N PF00107.26 ORX48584.1 - 0.058 13.4 0.2 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX48584.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Fcf2 PF08698.11 ORX48585.1 - 1.2e-34 118.5 1.1 1.2e-34 118.5 1.1 2.1 3 0 0 3 3 3 1 Fcf2 pre-rRNA processing PP28 PF10252.9 ORX48585.1 - 0.005 17.3 3.7 0.005 17.3 3.7 2.6 1 1 0 2 2 2 1 Casein kinase substrate phosphoprotein PP28 Lactonase PF10282.9 ORX48587.1 - 2.5e-93 313.1 0.1 2.9e-93 312.9 0.1 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller RL PF17797.1 ORX48587.1 - 0.034 14.1 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 RL domain DUF1513 PF07433.11 ORX48587.1 - 0.039 13.0 0.0 0.084 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) SWIB PF02201.18 ORX48588.1 - 9.2e-26 89.5 3.3 1e-25 89.4 1.0 2.3 2 0 0 2 2 2 1 SWIB/MDM2 domain DUF1053 PF06327.14 ORX48588.1 - 0.048 14.2 1.6 0.17 12.5 0.4 2.6 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1053) Yip1 PF04893.17 ORX48589.1 - 6.3e-12 45.6 9.0 7.1e-12 45.4 9.0 1.2 1 0 0 1 1 1 1 Yip1 domain DUF2374 PF09574.10 ORX48589.1 - 0.014 15.2 5.8 0.015 15.1 2.8 2.7 2 1 0 2 2 2 0 Protein of unknown function (Duf2374) DUF2070 PF09843.9 ORX48589.1 - 5.4 5.2 10.0 5.9 5.0 10.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Hep_59 PF07052.11 ORX48593.1 - 3.7e-31 108.0 4.8 3.7e-31 108.0 4.8 2.4 2 1 0 2 2 2 1 Hepatocellular carcinoma-associated antigen 59 DMPK_coil PF08826.10 ORX48593.1 - 0.51 10.5 7.5 0.22 11.7 0.6 3.3 1 1 1 3 3 3 0 DMPK coiled coil domain like BAR PF03114.18 ORX48594.1 - 1.3e-50 172.3 0.5 1.5e-50 172.1 0.5 1.0 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.13 ORX48594.1 - 0.019 14.5 1.6 0.19 11.3 0.1 2.1 2 0 0 2 2 2 0 Arfaptin-like domain BAR_3 PF16746.5 ORX48594.1 - 0.05 13.3 0.1 0.16 11.7 0.1 1.8 1 1 0 1 1 1 0 BAR domain of APPL family GerPC PF10737.9 ORX48594.1 - 0.082 13.0 1.2 4.8 7.2 0.2 2.8 3 0 0 3 3 3 0 Spore germination protein GerPC SHE3 PF17078.5 ORX48594.1 - 0.62 9.7 4.2 4.2 7.0 0.0 2.6 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Fungal_trans PF04082.18 ORX48595.1 - 0.00045 19.3 0.4 0.00095 18.3 0.4 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX48595.1 - 0.0017 18.4 11.4 0.0035 17.4 11.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Swi3 PF07962.12 ORX48596.1 - 3.4e-23 81.4 0.2 5e-23 80.9 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 PX PF00787.24 ORX48597.1 - 8.5e-10 38.6 1.0 2.3e-09 37.2 1.0 1.7 1 0 0 1 1 1 1 PX domain Response_reg PF00072.24 ORX48598.1 - 4.5e-23 81.5 0.1 1.7e-15 57.1 0.2 2.2 1 1 1 2 2 2 2 Response regulator receiver domain Autophagy_N PF03986.13 ORX48599.1 - 3.9e-44 149.9 2.1 5.6e-44 149.4 1.8 1.5 1 1 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_act_C PF03987.15 ORX48599.1 - 3.1e-21 75.7 0.5 9e-21 74.2 0.5 1.8 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Autophagy_C PF10381.9 ORX48599.1 - 6.4e-15 54.4 3.1 1.3e-14 53.4 3.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal PGM_PMM_I PF02878.16 ORX48600.1 - 3.4e-34 117.5 0.0 5.3e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ORX48600.1 - 6e-28 97.3 0.0 1e-27 96.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ORX48600.1 - 6e-15 55.7 0.1 2.2e-14 53.9 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 ORX48600.1 - 6.6e-07 29.4 0.0 1.4e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PUF PF00806.19 ORX48601.1 - 1.4e-66 216.6 18.6 2.4e-09 36.4 0.1 8.7 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Complex1_LYR_2 PF13233.6 ORX48601.1 - 0.0016 19.2 0.8 0.3 11.9 0.3 2.7 2 0 0 2 2 2 2 Complex1_LYR-like sCache_2 PF17200.4 ORX48601.1 - 0.038 13.8 1.1 22 4.9 0.0 4.4 5 0 0 5 5 5 0 Single Cache domain 2 Rad60-SLD_2 PF13881.6 ORX48603.1 - 1.7e-13 50.6 0.0 2e-13 50.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX48603.1 - 0.034 13.9 0.0 0.17 11.7 0.0 2.0 1 1 0 1 1 1 0 Ubiquitin family SET PF00856.28 ORX48604.1 - 1.4e-06 28.8 0.0 1.9e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 SET domain Snf7 PF03357.21 ORX48605.1 - 2.1e-10 40.5 19.4 3.4e-10 39.8 19.4 1.4 1 1 0 1 1 1 1 Snf7 DUF3886 PF13025.6 ORX48605.1 - 0.0069 16.6 4.9 0.022 15.0 4.9 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3886) PspA_IM30 PF04012.12 ORX48605.1 - 0.027 14.0 19.6 3.1 7.3 19.7 2.2 1 1 0 1 1 1 0 PspA/IM30 family DUF4272 PF14094.6 ORX48605.1 - 0.077 12.2 1.9 0.24 10.6 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4272) TBCA PF02970.16 ORX48605.1 - 0.4 11.1 10.1 0.077 13.3 5.1 2.2 1 1 0 2 2 2 0 Tubulin binding cofactor A Fes1 PF08609.10 ORX48605.1 - 2.8 8.9 8.5 2.8 8.9 5.4 2.6 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 OrfB_Zn_ribbon PF07282.11 ORX48606.1 - 5.1e-10 39.1 2.4 1e-09 38.2 2.4 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX48606.1 - 0.086 12.5 0.7 0.16 11.6 0.7 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Pox_Ag35 PF03286.14 ORX48606.1 - 0.11 12.3 0.4 0.21 11.4 0.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4503 PF14951.6 ORX48606.1 - 0.4 9.1 2.5 0.64 8.4 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) FA_hydroxylase PF04116.13 ORX48735.1 - 5.1e-23 81.9 12.0 6.1e-23 81.6 12.0 1.1 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily AA_permease_2 PF13520.6 ORX48736.1 - 1.3e-36 126.4 57.6 1.5e-36 126.2 47.8 2.7 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 ORX48736.1 - 4.1e-13 48.7 48.2 1.1e-07 30.9 20.3 2.8 1 1 1 3 3 3 2 Amino acid permease SMN PF06003.12 ORX48737.1 - 6.9e-07 28.8 4.8 8.6e-07 28.5 4.8 1.2 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Pex14_N PF04695.13 ORX48737.1 - 0.42 11.3 12.2 0.25 12.0 10.0 1.6 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ribosomal_L50 PF10501.9 ORX48739.1 - 6e-11 42.5 2.0 9.9e-11 41.8 2.0 1.5 1 1 0 1 1 1 1 Ribosomal subunit 39S SpoVIF PF14069.6 ORX48739.1 - 0.014 15.1 3.0 0.016 14.9 0.6 2.0 2 0 0 2 2 2 0 Stage VI sporulation protein F zf-PARP PF00645.18 ORX48740.1 - 9.1e-07 29.7 0.6 9.1e-07 29.7 0.6 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region DUF883 PF05957.13 ORX48740.1 - 0.0039 17.8 6.3 0.0039 17.8 6.3 2.3 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF883) PRTase_2 PF15609.6 ORX48740.1 - 0.083 12.4 0.2 0.083 12.4 0.2 1.7 2 0 0 2 2 2 0 Phosphoribosyl transferase DUF934 PF06073.12 ORX48740.1 - 0.12 12.2 1.4 0.3 11.0 1.4 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF934) GxGYxYP_C PF14323.6 ORX48740.1 - 0.17 11.7 1.3 0.33 10.8 1.3 1.4 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain HisKA_3 PF07730.13 ORX48740.1 - 1.1 9.8 8.8 1.3 9.5 6.1 2.5 1 1 1 2 2 2 0 Histidine kinase Syntaxin PF00804.25 ORX48740.1 - 1.3 8.7 12.3 0.22 11.2 7.0 2.1 2 0 0 2 2 2 0 Syntaxin Tho2 PF11262.8 ORX48740.1 - 1.4 8.1 6.2 2.7 7.1 6.2 1.4 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 YlqD PF11068.8 ORX48740.1 - 7.9 6.9 15.9 2.5 8.5 11.3 2.3 2 0 0 2 2 2 0 YlqD protein WGG PF10273.9 ORX48741.1 - 2e-29 102.1 0.7 3.5e-29 101.3 0.7 1.4 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF5611 PF18446.1 ORX48741.1 - 0.033 15.1 1.1 0.098 13.5 1.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5611) SDA1 PF05285.12 ORX48741.1 - 0.044 13.2 2.2 0.055 12.9 2.2 1.1 1 0 0 1 1 1 0 SDA1 Osteopontin PF00865.18 ORX48741.1 - 0.045 13.2 8.3 0.073 12.6 8.3 1.3 1 0 0 1 1 1 0 Osteopontin NOA36 PF06524.12 ORX48741.1 - 0.27 10.5 6.3 0.33 10.2 6.3 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 ORX48741.1 - 0.36 11.1 5.3 0.72 10.1 5.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Pkinase PF00069.25 ORX48742.1 - 1.2e-41 142.8 0.0 2.1e-41 142.0 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48742.1 - 5.4e-21 75.0 0.0 6.5e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX48742.1 - 0.035 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like RIO1 PF01163.22 ORX48742.1 - 0.16 11.6 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family DUF1640 PF07798.11 ORX48743.1 - 1.2e-33 116.6 6.3 1.3e-33 116.5 6.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Phage_cap_E PF03864.15 ORX48743.1 - 3.8 6.6 5.6 2.3 7.3 3.3 1.8 1 1 0 1 1 1 0 Phage major capsid protein E Mito_carr PF00153.27 ORX48744.1 - 3.5e-68 225.6 0.7 8.8e-24 83.3 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX48744.1 - 0.016 14.4 0.0 0.065 12.4 0.0 2.0 2 0 0 2 2 2 0 Gammaproteobacterial serine protease PsaL PF02605.15 ORX48744.1 - 0.026 14.2 0.4 0.43 10.2 0.1 2.6 3 0 0 3 3 3 0 Photosystem I reaction centre subunit XI DUF697 PF05128.12 ORX48744.1 - 0.12 12.0 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF697) Peptidase_M16 PF00675.20 ORX48745.1 - 7.2e-20 71.5 1.2 7.2e-20 71.5 1.2 2.0 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX48745.1 - 3e-11 43.7 1.3 4.3e-10 39.9 0.2 3.0 3 1 0 3 3 3 1 Peptidase M16 inactive domain FlxA PF14282.6 ORX48746.1 - 0.0017 18.3 0.1 0.0017 18.3 0.1 4.9 4 1 1 5 5 5 2 FlxA-like protein UXS1_N PF11803.8 ORX48746.1 - 0.15 12.4 0.2 0.74 10.2 0.2 2.3 1 0 0 1 1 1 0 UDP-glucuronate decarboxylase N-terminal FlaC_arch PF05377.11 ORX48746.1 - 0.17 12.3 7.2 1.4 9.4 0.2 4.3 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) PspB PF06667.12 ORX48746.1 - 0.23 11.5 2.4 17 5.5 0.4 3.2 2 0 0 2 2 2 0 Phage shock protein B bZIP_2 PF07716.15 ORX48746.1 - 1.9 8.6 15.4 3.9 7.6 1.4 4.4 3 0 0 3 3 3 0 Basic region leucine zipper DUF1690 PF07956.11 ORX48746.1 - 3.8 7.9 31.8 1.1 9.7 2.9 4.9 2 1 2 5 5 5 0 Protein of Unknown function (DUF1690) TRAF_BIRC3_bd PF16673.5 ORX48746.1 - 7.7 6.4 8.3 17 5.3 0.7 3.6 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain UQ_con PF00179.26 ORX48747.1 - 3.8e-40 136.8 0.1 4.9e-40 136.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF4160 PF13711.6 ORX48747.1 - 0.042 14.2 0.1 0.095 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) RWD PF05773.22 ORX48747.1 - 0.087 13.1 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 RWD domain DUF4456 PF14644.6 ORX48748.1 - 0.018 14.7 6.6 1.4 8.6 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4456) SSP160 PF06933.11 ORX48751.1 - 0.8 7.8 11.5 0.11 10.7 2.8 2.0 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Vps55 PF04133.14 ORX48754.1 - 1.5e-44 150.7 10.8 1.7e-44 150.5 10.8 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 PIRT PF15099.6 ORX48754.1 - 0.17 11.5 0.1 0.17 11.5 0.1 1.6 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Herpes_LMP1 PF05297.11 ORX48754.1 - 3.3 6.8 5.5 1.4 8.0 3.6 1.4 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Mlo PF03094.15 ORX48756.1 - 0.017 13.5 0.2 0.026 12.9 0.2 1.2 1 0 0 1 1 1 0 Mlo family O-FucT PF10250.9 ORX48758.1 - 4.7e-11 43.0 0.7 7.8e-09 35.7 0.7 3.1 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase CDC45 PF02724.14 ORX48758.1 - 0.24 9.7 4.1 0.32 9.2 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2722 PF10846.8 ORX48758.1 - 1.6 7.5 5.5 2.6 6.9 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DNA_pol_phi PF04931.13 ORX48758.1 - 3.3 5.7 13.1 5 5.1 13.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi IR1-M PF12185.8 ORX48758.1 - 3.9 7.5 10.9 0.17 11.8 0.4 3.1 2 1 1 3 3 3 0 Nup358/RanBP2 E3 ligase domain Redoxin PF08534.10 ORX48759.1 - 7.7e-37 126.3 0.1 9.4e-37 126.0 0.1 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 ORX48759.1 - 4.8e-11 42.6 0.0 5.8e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Metallophos PF00149.28 ORX48762.1 - 4.7e-37 128.5 0.1 6.1e-37 128.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX48762.1 - 1.4e-14 54.3 0.1 2.4e-14 53.5 0.1 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Zds_C PF08632.10 ORX48763.1 - 2.4e-24 84.8 2.1 4.7e-24 83.9 2.1 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF2854 PF11016.8 ORX48765.1 - 0.026 14.4 0.1 0.12 12.3 0.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2854) 4HBT PF03061.22 ORX48766.1 - 8.8e-09 35.6 0.0 2.4e-08 34.2 0.0 1.8 2 0 0 2 2 2 1 Thioesterase superfamily ELO PF01151.18 ORX48767.1 - 1e-64 218.5 21.5 1.3e-64 218.2 21.5 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family OrfB_Zn_ribbon PF07282.11 ORX48768.1 - 0.0017 18.2 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 ORX48768.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding Lar_restr_allev PF14354.6 ORX48768.1 - 0.14 12.6 0.0 0.45 10.9 0.0 1.9 1 0 0 1 1 1 0 Restriction alleviation protein Lar DUF678 PF05077.12 ORX48768.1 - 0.14 12.3 0.1 1.9 8.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) HTH_32 PF13565.6 ORX48769.1 - 5.1e-07 30.2 0.0 6.5e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX48769.1 - 3e-05 23.9 0.0 8.5e-05 22.5 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 ORX48769.1 - 4.8e-05 23.4 0.1 7.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX48769.1 - 0.00089 19.0 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX48769.1 - 0.049 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Complex1_LYR PF05347.15 ORX48770.1 - 7.4e-10 38.7 0.9 3.7e-09 36.5 0.9 2.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF1912 PF08930.10 ORX48770.1 - 0.011 15.8 0.1 0.095 12.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1912) AAA_23 PF13476.6 ORX48770.1 - 0.029 14.9 0.1 0.045 14.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain TraC_F_IV PF11130.8 ORX48770.1 - 0.65 9.6 4.1 0.21 11.1 0.4 2.0 2 1 0 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer Myosin_head PF00063.21 ORX48771.1 - 6.3e-265 880.6 0.1 6.3e-265 880.6 0.1 2.5 3 0 0 3 3 3 1 Myosin head (motor domain) DIL PF01843.19 ORX48771.1 - 1e-24 86.8 5.5 1e-24 86.8 5.5 3.3 2 1 1 3 3 3 1 DIL domain IQ PF00612.27 ORX48771.1 - 4.9e-08 32.1 29.4 0.0014 18.2 0.5 6.2 6 0 0 6 6 5 4 IQ calmodulin-binding motif IFT57 PF10498.9 ORX48771.1 - 0.00057 19.0 15.4 0.00057 19.0 15.4 2.1 2 0 0 2 2 2 1 Intra-flagellar transport protein 57 TMF_TATA_bd PF12325.8 ORX48771.1 - 0.003 17.8 18.3 0.05 13.8 15.7 3.6 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF1386 PF07138.11 ORX48771.1 - 0.017 14.4 1.2 0.19 11.0 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1386) AAA_22 PF13401.6 ORX48771.1 - 0.023 14.9 0.0 0.023 14.9 0.0 3.9 4 1 0 4 4 2 0 AAA domain ATG16 PF08614.11 ORX48771.1 - 0.028 14.6 29.2 0.16 12.2 24.1 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) AAA_16 PF13191.6 ORX48771.1 - 0.079 13.3 3.5 0.16 12.4 0.0 3.3 2 1 0 2 2 1 0 AAA ATPase domain DUF4337 PF14235.6 ORX48771.1 - 0.16 12.0 19.2 0.069 13.3 10.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DHR10 PF18595.1 ORX48771.1 - 0.2 11.7 28.2 0.025 14.7 9.4 4.0 2 1 1 3 3 2 0 Designed helical repeat protein 10 domain Uso1_p115_C PF04871.13 ORX48771.1 - 0.25 11.7 26.0 0.46 10.9 19.1 3.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region FdhD-NarQ PF02634.15 ORX48771.1 - 0.28 10.8 2.7 0.67 9.6 2.7 1.6 1 0 0 1 1 1 0 FdhD/NarQ family Tropomyosin_1 PF12718.7 ORX48771.1 - 1.3 9.2 23.5 0.03 14.5 9.5 3.1 1 1 1 2 2 2 0 Tropomyosin like TSC22 PF01166.18 ORX48771.1 - 2.5 8.5 9.5 23 5.4 0.0 4.3 3 1 1 4 4 4 0 TSC-22/dip/bun family DUF4407 PF14362.6 ORX48771.1 - 2.7 7.3 27.2 1.7e+02 1.3 27.2 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) HalX PF08663.10 ORX48771.1 - 2.8 8.3 13.6 6 7.3 0.0 4.1 2 1 2 4 4 4 0 HalX domain DUF724 PF05266.14 ORX48771.1 - 2.8 7.7 18.8 3.3 7.5 2.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Seryl_tRNA_N PF02403.22 ORX48771.1 - 3.2 8.0 19.9 3.2 8.0 3.9 3.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF2203 PF09969.9 ORX48771.1 - 4.1 8.1 18.6 1.3 9.7 5.6 3.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 ORX48771.1 - 4.6 7.9 15.5 44 4.8 4.4 4.8 3 0 0 3 3 3 0 SlyX FapA PF03961.13 ORX48771.1 - 5.3 5.5 14.4 4.4 5.8 11.8 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin_2 PF01920.20 ORX48771.1 - 5.8 6.9 19.8 3.2 7.7 3.7 3.9 3 0 0 3 3 3 0 Prefoldin subunit Atg14 PF10186.9 ORX48771.1 - 6 5.9 26.3 42 3.1 26.4 2.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Baculo_PEP_C PF04513.12 ORX48771.1 - 6 6.9 16.1 1.1e+03 -0.4 15.7 3.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ADIP PF11559.8 ORX48771.1 - 6.3 6.9 29.2 64 3.6 5.3 3.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ABC_tran PF00005.27 ORX48771.1 - 8.5 6.9 8.1 1.6 9.3 0.0 3.4 3 1 0 3 3 2 0 ABC transporter Csm1_N PF18504.1 ORX48771.1 - 9.5 6.6 17.4 6.3 7.2 0.2 4.0 3 0 0 3 3 3 0 Csm1 N-terminal domain UPF0029 PF01205.19 ORX48771.1 - 9.8 6.6 7.1 1.6 9.1 0.9 3.0 4 0 0 4 4 3 0 Uncharacterized protein family UPF0029 WW PF00397.26 ORX48772.1 - 9.3e-08 32.0 2.6 2.1e-07 30.9 2.6 1.7 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 ORX48772.1 - 2e-06 28.1 0.8 2.3e-06 27.8 0.8 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) DUF4813 PF16072.5 ORX48772.1 - 3.3e-05 23.7 6.4 4.1e-05 23.4 6.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4813) Pex14_N PF04695.13 ORX48772.1 - 0.11 13.2 2.8 0.15 12.7 2.8 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pyr_redox_2 PF07992.14 ORX48773.1 - 5e-52 177.0 0.0 8.6e-52 176.2 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX48773.1 - 3e-32 111.1 0.2 7.7e-32 109.8 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ORX48773.1 - 8.6e-18 64.7 1.6 2.2e-16 60.2 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX48773.1 - 3.3e-12 46.3 1.0 2.8e-09 36.7 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX48773.1 - 1.8e-05 23.6 2.1 0.0072 15.1 0.3 2.6 2 1 1 3 3 3 2 HI0933-like protein FAD_binding_2 PF00890.24 ORX48773.1 - 2.3e-05 23.7 6.1 0.00034 19.8 2.5 2.6 1 1 1 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ORX48773.1 - 0.0001 21.8 2.2 0.0019 17.6 1.8 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 ORX48773.1 - 0.00034 19.8 1.7 0.0061 15.7 1.3 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.24 ORX48773.1 - 0.00048 19.8 6.6 0.016 14.8 0.0 2.7 2 1 0 3 3 3 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ORX48773.1 - 0.0014 18.0 0.5 0.5 9.6 0.1 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ORX48773.1 - 0.0015 17.9 0.2 0.0056 16.1 0.0 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ORX48773.1 - 0.0037 17.2 0.0 0.057 13.3 0.0 2.3 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ORX48773.1 - 0.006 16.2 0.0 0.011 15.3 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_8 PF13450.6 ORX48773.1 - 0.0082 16.3 1.2 0.02 15.1 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX48773.1 - 0.0087 15.3 1.5 6.1 6.0 0.3 3.1 3 0 0 3 3 3 1 FAD binding domain NAD_binding_7 PF13241.6 ORX48773.1 - 0.039 14.4 0.0 8.2 6.9 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding K_oxygenase PF13434.6 ORX48773.1 - 0.1 11.7 0.1 9.3 5.3 0.0 2.6 1 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) NAD_Gly3P_dh_N PF01210.23 ORX48773.1 - 0.17 11.9 0.0 2 8.4 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NP1-WLL PF11733.8 ORX48775.1 - 0.051 13.3 0.0 0.065 13.0 0.0 1.3 1 0 0 1 1 1 0 Non-capsid protein NP1 DnaG_DnaB_bind PF08278.11 ORX48775.1 - 0.079 13.6 0.5 0.14 12.7 0.1 1.6 2 1 0 2 2 2 0 DNA primase DnaG DnaB-binding Pyr_redox_2 PF07992.14 ORX48776.1 - 2e-65 220.9 0.3 2.7e-65 220.5 0.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX48776.1 - 3e-32 111.1 0.2 8.1e-32 109.8 0.2 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ORX48776.1 - 2.4e-18 66.4 1.7 2.2e-16 60.1 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX48776.1 - 9.1e-16 58.0 0.7 2.6e-15 56.5 0.7 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX48776.1 - 3.7e-09 36.5 0.1 7.6e-08 32.1 0.1 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX48776.1 - 2.1e-06 26.7 2.4 0.0011 17.8 0.5 2.9 3 1 1 4 4 4 2 HI0933-like protein K_oxygenase PF13434.6 ORX48776.1 - 6.4e-06 25.5 0.1 0.0023 17.1 0.0 2.6 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 ORX48776.1 - 8.8e-05 21.7 2.5 0.0014 17.8 2.0 2.2 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ORX48776.1 - 0.00013 21.2 9.5 0.00059 19.0 3.1 2.9 2 1 1 3 3 3 1 FAD binding domain NAD_binding_8 PF13450.6 ORX48776.1 - 0.00014 22.0 2.9 0.00014 22.0 2.9 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 ORX48776.1 - 0.0019 17.6 0.9 0.0042 16.5 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX48776.1 - 0.0025 17.1 1.9 0.47 9.7 0.1 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX48776.1 - 0.0066 16.0 0.0 0.012 15.2 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Thi4 PF01946.17 ORX48776.1 - 0.0082 15.4 0.2 0.02 14.2 0.2 1.6 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 ORX48776.1 - 0.013 15.1 14.0 0.023 14.3 3.2 2.7 2 1 0 3 3 3 0 FAD dependent oxidoreductase 3HCDH_N PF02737.18 ORX48776.1 - 0.015 15.2 0.7 0.059 13.3 0.0 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ORX48776.1 - 0.02 14.1 2.9 7.3 5.7 0.8 3.1 3 0 0 3 3 3 0 FAD binding domain NAD_binding_7 PF13241.6 ORX48776.1 - 0.12 12.9 0.4 7.4 7.1 0.0 2.7 3 0 0 3 3 3 0 Putative NAD(P)-binding DUF4052 PF13261.6 ORX48777.1 - 0.053 13.4 3.4 0.061 13.2 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4052) Imm59 PF15597.6 ORX48777.1 - 0.13 12.8 0.0 0.2 12.1 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 59 zf-C2H2_2 PF12756.7 ORX48779.1 - 7.6e-05 23.0 2.4 0.00021 21.6 2.5 1.6 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX48779.1 - 0.00044 20.9 7.9 0.016 16.0 0.6 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX48779.1 - 0.00071 19.9 6.9 0.0014 19.0 0.5 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF629 PF04780.12 ORX48779.1 - 0.01 14.4 0.2 0.01 14.4 0.2 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF629) E6 PF00518.17 ORX48779.1 - 0.038 14.4 0.6 0.11 13.0 0.1 1.8 1 1 1 2 2 2 0 Early Protein (E6) zf-C2H2_jaz PF12171.8 ORX48779.1 - 0.077 13.3 0.6 0.077 13.3 0.6 2.5 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding XPA_N PF01286.18 ORX48779.1 - 0.12 12.5 1.7 0.73 9.9 0.2 2.3 2 0 0 2 2 2 0 XPA protein N-terminal zf-Di19 PF05605.12 ORX48779.1 - 0.12 12.7 5.7 1 9.7 1.9 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Evr1_Alr PF04777.13 ORX48779.1 - 0.28 11.7 3.1 0.55 10.7 0.5 2.0 1 1 1 2 2 2 0 Erv1 / Alr family zf_ZIC PF18366.1 ORX48779.1 - 1.9 8.7 6.1 3.7 7.7 2.5 2.4 2 1 0 2 2 2 0 Zic proteins zinc finger domain Fungal_trans PF04082.18 ORX48780.1 - 0.00057 19.0 4.3 0.0013 17.8 4.3 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain DPM2 PF07297.12 ORX48780.1 - 0.019 15.3 0.0 0.043 14.1 0.0 1.6 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) AAA_12 PF13087.6 ORX48781.1 - 1.9e-41 141.9 0.0 3.1e-41 141.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX48781.1 - 1.1e-24 87.7 0.1 7.6e-12 45.6 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ORX48781.1 - 1e-09 38.8 0.0 4.2e-06 27.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 ORX48781.1 - 1.5e-09 37.9 0.1 0.0002 21.2 0.0 3.3 2 1 1 3 3 3 2 AAA domain PhoH PF02562.16 ORX48781.1 - 0.0022 17.5 0.1 0.0072 15.8 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein ResIII PF04851.15 ORX48781.1 - 0.0027 17.8 0.0 0.031 14.3 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX48781.1 - 0.0087 15.8 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.9 ORX48781.1 - 0.012 14.9 0.1 0.37 10.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF2786 PF10979.8 ORX48781.1 - 0.014 15.3 1.5 0.028 14.3 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2786) UvrD-helicase PF00580.21 ORX48781.1 - 0.096 12.2 0.0 0.98 8.9 0.0 2.2 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Kinase-like PF14531.6 ORX48781.1 - 0.14 11.4 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Kinase-like HMG_box PF00505.19 ORX48782.1 - 5.5e-06 26.7 1.1 3e-05 24.3 1.1 2.1 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX48782.1 - 0.028 15.0 0.1 0.053 14.1 0.1 1.5 1 0 0 1 1 1 0 HMG-box domain TPT PF03151.16 ORX48783.1 - 1.1e-64 218.6 20.5 1.3e-64 218.4 20.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ORX48783.1 - 7.3e-14 52.1 26.4 9.5e-09 35.5 9.2 2.4 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ORX48783.1 - 2.7e-12 46.5 22.4 3.5e-12 46.2 22.4 1.1 1 0 0 1 1 1 1 UAA transporter family Multi_Drug_Res PF00893.19 ORX48783.1 - 0.018 15.7 2.4 0.018 15.7 2.4 3.1 3 1 0 3 3 3 0 Small Multidrug Resistance protein Kelch_2 PF07646.15 ORX48785.1 - 0.00022 21.1 0.0 0.00097 19.0 0.0 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ORX48785.1 - 0.041 14.2 0.0 0.087 13.2 0.0 1.5 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 ORX48785.1 - 0.12 12.5 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Galactose oxidase, central domain NPBW PF15180.6 ORX48785.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Neuropeptides B and W zf-C2H2_4 PF13894.6 ORX48786.1 - 0.0013 19.4 2.0 0.12 13.3 0.4 3.1 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX48786.1 - 0.0027 18.1 0.5 0.0027 18.1 0.5 2.9 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf_C2H2_ZHX PF18387.1 ORX48786.1 - 0.0031 17.1 1.0 0.24 11.0 0.3 3.0 3 0 0 3 3 3 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 ORX48786.1 - 0.0037 17.6 0.7 0.013 15.8 0.7 1.9 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ORX48786.1 - 0.043 14.2 0.2 0.2 12.1 0.2 2.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type DUF1386 PF07138.11 ORX48786.1 - 0.053 12.8 0.0 0.26 10.5 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1386) Tom37_C PF11801.8 ORX48786.1 - 0.059 13.3 0.1 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Tom37 C-terminal domain SidC_N PF18219.1 ORX48786.1 - 0.061 12.3 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 SidC N-terminal domain zf-C2H2_jaz PF12171.8 ORX48786.1 - 0.28 11.5 2.1 1.6 9.1 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Cellulase PF00150.18 ORX48787.1 - 2e-14 53.7 0.0 1.6e-08 34.4 0.0 2.9 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 ORX48787.1 - 5.9e-09 36.3 0.0 1.3e-08 35.2 0.0 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Exo70 PF03081.15 ORX48788.1 - 1.5e-68 231.6 0.2 2.1e-68 231.1 0.2 1.1 1 0 0 1 1 1 1 Exo70 exocyst complex subunit DUF2935 PF11155.8 ORX48788.1 - 0.0056 17.0 0.1 8.9 6.7 0.0 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF2935) DHHC PF01529.20 ORX48789.1 - 2e-35 121.8 14.1 2e-35 121.8 14.1 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4598 PF15370.6 ORX48790.1 - 1e-17 64.6 0.5 1.8e-17 63.8 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) Pterin_4a PF01329.19 ORX48791.1 - 3e-32 110.7 0.0 3.2e-32 110.5 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase FYVE PF01363.21 ORX48793.1 - 3e-24 84.9 21.2 1.8e-17 63.2 6.4 2.6 2 0 0 2 2 2 2 FYVE zinc finger Rbsn PF11464.8 ORX48793.1 - 4.1e-11 42.4 0.3 9.3e-11 41.3 0.3 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-AN1 PF01428.16 ORX48793.1 - 0.011 15.8 5.2 0.011 15.8 5.2 3.7 4 1 0 4 4 4 0 AN1-like Zinc finger IBR PF01485.21 ORX48793.1 - 0.063 13.5 19.3 0.4 10.9 2.2 3.4 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Zn-C2H2_12 PF18112.1 ORX48793.1 - 0.15 12.6 0.4 0.15 12.6 0.4 2.8 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain FAM72 PF14976.6 ORX48794.1 - 4.5e-50 169.6 7.7 4.9e-50 169.4 7.7 1.0 1 0 0 1 1 1 1 FAM72 protein Yippee-Mis18 PF03226.14 ORX48794.1 - 0.082 13.1 9.9 0.15 12.3 9.9 1.4 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Zn_clus PF00172.18 ORX48795.1 - 0.0013 18.8 16.0 0.0025 17.9 16.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lin-8 PF03353.15 ORX48795.1 - 0.11 12.1 2.8 0.15 11.6 2.8 1.3 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist SPX PF03105.19 ORX48795.1 - 0.79 9.6 6.3 0.98 9.3 6.3 1.2 1 0 0 1 1 1 0 SPX domain Mito_carr PF00153.27 ORX48796.1 - 4.1e-55 183.7 1.1 3.4e-19 68.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein UPF0154 PF03672.13 ORX48796.1 - 0.011 15.7 0.1 0.069 13.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) DUF2268 PF10026.9 ORX48796.1 - 0.035 13.7 0.0 0.073 12.6 0.0 1.5 2 0 0 2 2 2 0 Predicted Zn-dependent protease (DUF2268) BChl_A PF02327.17 ORX48796.1 - 0.056 12.2 0.0 0.085 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacteriochlorophyll A protein P5CR_dimer PF14748.6 ORX48797.1 - 4.4e-34 116.8 1.7 7.8e-34 116.0 1.7 1.4 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 ORX48797.1 - 1.7e-13 50.9 0.0 4.5e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.23 ORX48797.1 - 0.00014 21.9 1.6 0.004 17.1 0.2 3.1 3 1 1 4 4 4 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Phosducin PF02114.16 ORX48798.1 - 3.8e-15 55.5 0.7 2.3e-11 43.1 0.0 2.6 1 1 1 2 2 2 1 Phosducin LPD22 PF18834.1 ORX48798.1 - 0.016 15.4 0.7 0.034 14.3 0.7 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 REV PF00424.18 ORX48798.1 - 0.067 13.2 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) GRAS PF03514.14 ORX48798.1 - 0.086 11.8 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 GRAS domain family Pkinase PF00069.25 ORX48799.1 - 6e-45 153.7 0.0 1.1e-31 110.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48799.1 - 2.3e-28 99.2 0.0 4.9e-28 98.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX48799.1 - 2.6e-06 27.0 0.0 2.5e-05 23.7 0.0 2.3 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX48799.1 - 4.7e-06 25.6 0.4 7.9e-06 24.9 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX48799.1 - 0.00093 19.2 0.2 0.0022 18.0 0.2 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Rad50_zn_hook PF04423.14 ORX48799.1 - 0.017 15.0 0.4 0.017 15.0 0.4 2.0 2 0 0 2 2 2 0 Rad50 zinc hook motif Wbp11 PF09429.10 ORX48799.1 - 0.36 11.3 6.0 0.25 11.8 2.9 2.3 2 0 0 2 2 2 0 WW domain binding protein 11 Rep_fac-A_3 PF08661.11 ORX48800.1 - 1.7e-17 63.7 0.0 1.9e-17 63.5 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 ECH_1 PF00378.20 ORX48801.1 - 3.3e-26 92.1 0.0 4.2e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX48801.1 - 4.3e-11 42.9 0.0 4.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF2968 PF11180.8 ORX48802.1 - 0.3 10.7 19.4 0.59 9.7 19.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) Draxin PF15550.6 ORX48802.1 - 0.73 9.6 8.6 1.1 9.1 8.6 1.3 1 0 0 1 1 1 0 Draxin YjbH PF06082.11 ORX48802.1 - 9 5.0 8.1 11 4.7 8.1 1.1 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH Kinesin PF00225.23 ORX48803.1 - 1.7e-93 313.2 0.1 2.2e-93 312.8 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX48803.1 - 2.7e-22 79.3 0.1 5.1e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 Microtubule binding Baculo_p33 PF05214.12 ORX48803.1 - 0.1 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Baculovirus P33 AAA_16 PF13191.6 ORX48803.1 - 0.15 12.4 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Fungal_trans PF04082.18 ORX48804.1 - 0.00015 20.9 0.1 0.00043 19.4 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX48804.1 - 0.00015 21.8 10.2 0.00031 20.8 10.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RNase_P_Rpp14 PF01900.19 ORX48805.1 - 2.6e-06 27.6 0.0 3.2e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family NAP PF00956.18 ORX48806.1 - 4.3e-13 49.1 8.6 4.3e-13 49.1 8.6 3.0 2 1 1 3 3 3 2 Nucleosome assembly protein (NAP) DUF1447 PF07288.11 ORX48806.1 - 0.028 14.5 0.5 0.19 11.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1447) Kelch_4 PF13418.6 ORX48807.1 - 5e-13 48.8 15.7 5.1e-05 23.2 0.0 4.3 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX48807.1 - 4.5e-12 45.9 7.8 2.9e-05 24.2 0.2 3.8 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX48807.1 - 2.5e-09 36.9 11.2 0.00051 20.0 0.2 4.7 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ORX48807.1 - 7.8e-08 32.3 4.2 0.0059 16.9 0.2 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ORX48807.1 - 0.001 18.6 6.2 0.041 13.5 1.5 3.9 3 1 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ORX48807.1 - 0.0064 16.4 2.7 0.029 14.4 0.2 3.0 3 0 0 3 3 3 1 Kelch motif VSP PF03302.13 ORX48807.1 - 0.0087 14.9 1.3 0.012 14.5 1.3 1.1 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF4690 PF15756.5 ORX48807.1 - 9.9 6.8 6.8 1 10.0 0.6 2.3 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Mannosyl_trans3 PF11051.8 ORX48808.1 - 7.3e-43 146.9 0.3 7.7e-28 97.6 0.0 2.4 1 1 1 2 2 2 2 Mannosyltransferase putative RNase_PH PF01138.21 ORX48810.1 - 4e-32 111.5 0.0 6.7e-32 110.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 KSHV_K1 PF11049.8 ORX48810.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus His_Phos_1 PF00300.22 ORX48811.1 - 1.2e-18 67.5 0.0 2.3e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF4123 PF13503.6 ORX48812.1 - 2.9e-05 24.5 2.0 0.064 13.7 0.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4123) Lar_restr_allev PF14354.6 ORX48812.1 - 0.0036 17.6 3.8 12 6.3 0.0 4.0 4 0 0 4 4 4 1 Restriction alleviation protein Lar SNAP PF14938.6 ORX48812.1 - 0.016 14.7 0.0 0.016 14.6 0.0 1.0 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP Glyoxalase_4 PF13669.6 ORX48812.1 - 0.017 15.4 0.1 4.1 7.7 0.0 3.3 1 1 1 2 2 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HTH_AraC PF00165.23 ORX48812.1 - 0.03 14.4 3.1 53 4.1 0.0 4.2 3 2 2 5 5 5 0 Bacterial regulatory helix-turn-helix proteins, AraC family TMP-TENI PF02581.17 ORX48812.1 - 0.054 12.8 0.2 0.62 9.4 0.2 2.1 1 1 0 1 1 1 0 Thiamine monophosphate synthase NSF PF02071.20 ORX48812.1 - 0.058 14.1 1.3 4.1e+02 2.6 0.0 4.5 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat HsbA PF12296.8 ORX48812.1 - 0.11 12.9 4.0 3.2 8.2 0.6 2.1 1 1 1 2 2 2 0 Hydrophobic surface binding protein A EHN PF06441.12 ORX48812.1 - 0.15 12.5 2.8 1.5 9.2 2.8 2.2 1 1 0 1 1 1 0 Epoxide hydrolase N terminus DUF3209 PF11483.8 ORX48814.1 - 0.0052 17.3 0.4 0.0066 16.9 0.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3209) His_Phos_1 PF00300.22 ORX48816.1 - 5.6e-21 75.1 0.0 1.5e-20 73.7 0.0 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Glyco_hydro_75 PF07335.11 ORX48816.1 - 0.063 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Fungal chitosanase of glycosyl hydrolase group 75 zf-C2H2_4 PF13894.6 ORX48817.1 - 0.0003 21.3 0.4 0.00052 20.6 0.4 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX48817.1 - 0.0084 16.4 1.5 0.0095 16.3 1.5 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 ORX48817.1 - 0.026 14.4 0.3 0.051 13.4 0.2 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2HE PF16278.5 ORX48817.1 - 0.028 14.9 0.2 0.037 14.5 0.2 1.2 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 ORX48817.1 - 0.059 13.4 1.0 0.098 12.7 1.0 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX48817.1 - 0.073 13.6 1.0 0.15 12.6 1.0 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type Aa_trans PF01490.18 ORX48818.1 - 1.9e-33 115.8 27.1 3e-33 115.2 27.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX48818.1 - 0.15 10.8 49.1 11 4.7 49.1 3.3 1 1 0 1 1 1 0 Amino acid permease COG5 PF10392.9 ORX48819.1 - 4.9e-25 88.2 3.0 1.2e-24 86.9 0.8 2.7 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Vps51 PF08700.11 ORX48819.1 - 4.4e-06 26.7 0.4 1.5e-05 24.9 0.4 2.0 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ORX48819.1 - 0.00076 19.6 1.2 0.0037 17.4 0.2 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF29 PF01724.16 ORX48819.1 - 0.072 13.3 0.3 0.5 10.6 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function DUF29 Atg8 PF02991.16 ORX48820.1 - 3.9e-52 174.8 0.1 5.1e-52 174.4 0.1 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 ORX48820.1 - 5.7e-07 29.9 0.0 7.2e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Myb_DNA-binding PF00249.31 ORX48821.1 - 1.4e-05 25.2 0.0 2.4e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX48821.1 - 0.00095 19.4 0.1 0.0018 18.5 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Aa_trans PF01490.18 ORX48822.1 - 3.3e-79 266.5 22.3 4.1e-79 266.2 22.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF202 PF02656.15 ORX48822.1 - 0.17 12.3 0.2 0.17 12.3 0.2 3.7 4 2 0 4 4 4 0 Domain of unknown function (DUF202) Fumble PF03630.14 ORX48823.1 - 1.3e-135 451.8 0.0 4.3e-135 450.1 0.0 1.7 1 1 0 1 1 1 1 Fumble Crr6 PF08847.11 ORX48824.1 - 0.15 11.7 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Chlororespiratory reduction 6 WD40 PF00400.32 ORX48825.1 - 6.2e-19 68.0 13.4 3e-07 31.0 0.1 6.7 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX48825.1 - 1e-13 51.4 10.2 3.2e-06 27.3 0.2 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX48825.1 - 1.7e-05 24.8 2.9 0.00044 20.2 0.3 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DEAD PF00270.29 ORX48826.1 - 1.9e-27 96.2 0.0 4.1e-27 95.1 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX48826.1 - 3.9e-16 59.4 0.0 1.7e-14 54.1 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF1998 PF09369.10 ORX48826.1 - 2e-10 41.2 1.1 6.2e-10 39.7 1.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) ResIII PF04851.15 ORX48826.1 - 5.1e-08 33.1 0.0 9e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Cation_ATPase_C PF00689.21 ORX48828.1 - 1.5e-39 135.6 5.4 1.5e-39 135.6 5.4 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ORX48828.1 - 2.4e-38 131.5 2.1 2.4e-38 131.5 2.1 2.2 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX48828.1 - 1.1e-21 78.1 0.7 3.4e-16 60.2 0.1 3.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX48828.1 - 1.5e-15 57.1 0.0 2.8e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX48828.1 - 1.5e-07 31.0 0.2 5.8e-07 29.1 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX48828.1 - 0.0015 18.3 0.2 0.0039 17.0 0.2 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX48828.1 - 0.12 12.7 0.0 1.6 9.1 0.0 2.4 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_C42 PF05533.12 ORX48830.1 - 0.09 12.8 0.0 0.098 12.7 0.0 1.1 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 Porphobil_deam PF01379.20 ORX48831.1 - 8.3e-67 224.6 0.0 1e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ORX48831.1 - 5.4e-19 68.4 0.1 1.1e-18 67.4 0.1 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain Integrin_beta PF00362.18 ORX48831.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.4 2 0 0 2 2 2 1 Integrin beta chain VWA domain SCRL PF06876.12 ORX48831.1 - 0.055 13.6 0.5 0.092 12.9 0.5 1.3 1 0 0 1 1 1 0 Plant self-incompatibility response (SCRL) protein SYS1 PF09801.9 ORX48832.1 - 8.3e-32 110.3 9.6 1e-31 110.0 9.6 1.1 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network PCI PF01399.27 ORX48833.1 - 2.5e-07 31.2 0.5 5.9e-07 30.0 0.5 1.6 1 0 0 1 1 1 1 PCI domain Urb2 PF10441.9 ORX48833.1 - 1.1 9.1 4.6 18 5.2 2.9 3.0 2 1 0 2 2 2 0 Urb2/Npa2 family Usp PF00582.26 ORX48834.1 - 1.2e-17 64.7 0.0 4.2e-17 63.0 0.0 1.9 1 1 0 1 1 1 1 Universal stress protein family Peroxin-3 PF04882.12 ORX48835.1 - 1.4e-124 416.7 12.5 6.7e-124 414.4 12.5 1.8 1 1 0 1 1 1 1 Peroxin-3 Ras PF00071.22 ORX48836.1 - 1.4e-55 187.4 0.0 1.6e-55 187.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX48836.1 - 6.6e-22 78.0 0.0 9.9e-22 77.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX48836.1 - 1.4e-07 31.2 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX48836.1 - 0.0081 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit mRNA_triPase PF02940.15 ORX48837.1 - 8e-46 156.5 1.7 1.1e-45 156.1 1.7 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Trans_coact PF16805.5 ORX48837.1 - 0.037 14.1 0.5 1.7 8.8 0.1 2.6 2 0 0 2 2 2 0 Phage late-transcription coactivator zf-SNAP50_C PF12251.8 ORX48838.1 - 1.3e-48 165.4 6.3 2.1e-48 164.7 6.3 1.4 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal Carn_acyltransf PF00755.20 ORX48839.1 - 1.9e-215 716.9 0.2 2.2e-215 716.7 0.2 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase CBFB_NFYA PF02045.15 ORX48840.1 - 1.5e-29 102.4 7.2 2.9e-29 101.5 7.2 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B SAE2 PF08573.10 ORX48840.1 - 0.27 12.3 7.9 0.54 11.4 7.9 1.6 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus TFIIA PF03153.13 ORX48840.1 - 2.4 8.1 11.6 2.9 7.8 11.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pro_isomerase PF00160.21 ORX48841.1 - 4.4e-50 170.0 0.2 1.2e-49 168.7 0.1 1.8 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Rtf2 PF04641.12 ORX48841.1 - 3.5e-06 26.6 2.7 1.4e-05 24.6 0.1 2.5 2 1 0 2 2 2 1 Rtf2 RING-finger zf-NOSIP PF15906.5 ORX48841.1 - 6.7e-06 26.1 0.0 2.1e-05 24.5 0.0 1.9 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein U-box PF04564.15 ORX48841.1 - 0.0011 19.1 0.1 0.066 13.4 0.0 2.7 2 0 0 2 2 2 1 U-box domain sCache_like PF16736.5 ORX48841.1 - 0.026 14.6 0.3 0.057 13.5 0.3 1.6 1 0 0 1 1 1 0 Single Cache-like DUF3806 PF12713.7 ORX48841.1 - 0.13 12.1 0.1 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3806) zf-Nse PF11789.8 ORX48841.1 - 0.15 11.9 0.2 2 8.3 0.1 2.5 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DUF4477 PF14780.6 ORX48842.1 - 6.1e-16 58.6 3.6 8.3e-16 58.2 3.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4477) BolA PF01722.18 ORX48844.1 - 1.1e-15 57.6 0.0 2.2e-15 56.7 0.0 1.5 1 1 0 1 1 1 1 BolA-like protein TFIIS_C PF01096.18 ORX48845.1 - 1.7e-17 62.9 2.3 1.7e-17 62.9 2.3 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX48845.1 - 1e-10 41.3 11.2 1.8e-07 30.9 0.9 2.9 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 ORX48845.1 - 6.9e-06 26.0 6.6 0.0076 16.3 0.1 2.7 2 1 0 2 2 2 2 Double zinc ribbon DUF523 PF04463.12 ORX48845.1 - 0.00012 22.1 0.3 0.00015 21.8 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF523) Lar_restr_allev PF14354.6 ORX48845.1 - 0.0013 19.0 7.5 0.068 13.6 1.1 2.6 2 1 0 2 2 2 2 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 ORX48845.1 - 0.0027 17.6 5.8 0.0084 16.1 0.5 2.7 2 1 0 2 2 2 1 Transposase zinc-ribbon domain DNA_RNApol_7kD PF03604.13 ORX48845.1 - 0.0035 17.0 14.0 0.069 12.8 4.0 3.9 3 1 1 4 4 4 1 DNA directed RNA polymerase, 7 kDa subunit TF_Zn_Ribbon PF08271.12 ORX48845.1 - 0.0088 15.5 11.2 0.067 12.7 0.9 3.5 2 2 0 2 2 2 1 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX48845.1 - 0.011 15.8 14.5 2.5 8.3 0.2 3.9 3 1 1 4 4 4 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 ORX48845.1 - 0.011 15.6 8.2 2.7 8.0 0.1 4.1 4 0 0 4 4 4 0 zinc-ribbon domain eIF-5_eIF-2B PF01873.17 ORX48845.1 - 0.014 15.2 6.1 0.33 10.8 1.6 2.4 2 1 0 2 2 2 0 Domain found in IF2B/IF5 HypA PF01155.19 ORX48845.1 - 0.021 14.8 8.8 1.9 8.5 0.3 3.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 ORX48845.1 - 0.025 14.0 18.7 1.4 8.4 0.4 4.2 3 1 0 3 3 3 0 zinc-ribbon domain DUF2387 PF09526.10 ORX48845.1 - 0.029 14.5 4.6 0.59 10.3 0.3 2.4 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) zf-H2C2_2 PF13465.6 ORX48845.1 - 0.034 14.6 8.8 0.064 13.7 0.2 3.5 4 0 0 4 4 3 0 Zinc-finger double domain Ogr_Delta PF04606.12 ORX48845.1 - 0.051 13.6 1.1 0.051 13.6 1.1 2.1 3 0 0 3 3 1 0 Ogr/Delta-like zinc finger Nudix_N_2 PF14803.6 ORX48845.1 - 0.053 13.5 11.2 1.2 9.2 2.6 3.6 2 2 0 2 2 2 0 Nudix N-terminal tRNA-synt_1f PF01921.18 ORX48845.1 - 0.057 12.3 2.1 0.057 12.3 0.9 1.5 1 1 1 2 2 2 0 tRNA synthetases class I (K) Baculo_LEF5_C PF11792.8 ORX48845.1 - 0.089 12.5 0.6 0.089 12.5 0.6 2.7 3 1 1 4 4 3 0 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_2 PF13240.6 ORX48845.1 - 0.1 12.4 19.4 4.1 7.3 4.6 4.1 3 1 1 4 4 4 0 zinc-ribbon domain Mu-like_Com PF10122.9 ORX48845.1 - 0.13 11.8 2.3 8.2 6.0 0.0 2.7 3 0 0 3 3 2 0 Mu-like prophage protein Com NOB1_Zn_bind PF08772.11 ORX48845.1 - 0.14 12.3 10.7 25 5.1 0.1 3.7 2 1 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like CpXC PF14353.6 ORX48845.1 - 0.3 11.2 11.0 7.6 6.6 2.5 3.8 1 1 2 3 3 3 0 CpXC protein Zn_ribbon_recom PF13408.6 ORX48845.1 - 0.36 11.4 9.4 16 6.1 0.2 3.4 3 1 0 3 3 3 0 Recombinase zinc beta ribbon domain OrfB_Zn_ribbon PF07282.11 ORX48845.1 - 0.39 10.7 8.4 2.3 8.2 0.2 2.8 2 1 0 2 2 2 0 Putative transposase DNA-binding domain DUF3797 PF12677.7 ORX48845.1 - 0.4 10.6 6.3 0.39 10.6 1.4 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3797) zinc_ribbon_5 PF13719.6 ORX48845.1 - 0.44 10.4 6.7 29 4.5 0.0 3.9 4 0 0 4 4 4 0 zinc-ribbon domain A2L_zn_ribbon PF08792.10 ORX48845.1 - 0.47 10.2 15.1 6.1 6.7 0.5 4.2 4 0 0 4 4 4 0 A2L zinc ribbon domain Tnp_zf-ribbon_2 PF13842.6 ORX48845.1 - 0.5 11.2 7.5 43 5.0 0.1 3.8 4 0 0 4 4 3 0 DDE_Tnp_1-like zinc-ribbon Ribosomal_S27e PF01667.17 ORX48845.1 - 0.55 10.0 9.7 2 8.2 0.5 3.3 2 2 0 2 2 2 0 Ribosomal protein S27 zf-C4_Topoisom PF01396.19 ORX48845.1 - 0.85 9.5 12.5 0.95 9.3 5.0 3.6 3 1 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger DUF3268 PF11672.8 ORX48845.1 - 1 9.7 7.3 0.22 11.8 1.5 2.5 2 1 1 3 3 3 0 zinc-finger-containing domain Zn_Tnp_IS91 PF14319.6 ORX48845.1 - 1.2 9.2 10.2 0.36 10.9 3.0 2.5 1 1 0 2 2 2 0 Transposase zinc-binding domain Elf1 PF05129.13 ORX48845.1 - 1.2 9.2 10.4 0.49 10.5 2.5 2.8 1 1 0 2 2 2 0 Transcription elongation factor Elf1 like Prok-RING_1 PF14446.6 ORX48845.1 - 1.8 8.5 10.3 3.4 7.7 2.0 3.4 3 1 0 3 3 3 0 Prokaryotic RING finger family 1 zinc_ribbon_9 PF14369.6 ORX48845.1 - 1.9 8.8 8.2 6.2 7.2 0.1 3.0 3 1 0 3 3 3 0 zinc-ribbon GATA PF00320.27 ORX48845.1 - 2.1 8.0 8.5 0.78 9.4 0.1 3.2 3 1 0 3 3 3 0 GATA zinc finger zf-AN1 PF01428.16 ORX48845.1 - 2.5 8.3 10.9 12 6.2 0.4 3.5 3 1 1 4 4 4 0 AN1-like Zinc finger zf-RING_7 PF02591.15 ORX48845.1 - 2.6 8.3 17.0 11 6.3 0.3 4.5 4 1 0 4 4 4 0 C4-type zinc ribbon domain PADR1 PF08063.12 ORX48845.1 - 3 7.7 11.9 2.8 7.8 0.1 3.8 3 1 1 4 4 4 0 PADR1 (NUC008) domain zf-Mss51 PF13824.6 ORX48845.1 - 3.3 7.9 12.6 2.8 8.1 3.5 3.5 2 2 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_13 PF09855.9 ORX48845.1 - 4 7.7 14.8 17 5.7 0.1 3.9 2 2 1 3 3 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) UPF0547 PF10571.9 ORX48845.1 - 4 7.6 17.2 8.8 6.5 0.3 4.1 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 zf-RRN7 PF11781.8 ORX48845.1 - 4.5 7.0 13.6 4.7 7.0 3.7 4.0 3 1 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ZPR1 PF03367.13 ORX48845.1 - 4.6 7.1 9.6 0.32 10.9 0.8 2.6 2 1 1 3 3 3 0 ZPR1 zinc-finger domain Rubredoxin_2 PF18073.1 ORX48845.1 - 5.1 6.9 23.9 3.1 7.6 1.1 4.2 4 0 0 4 4 4 0 Rubredoxin metal binding domain Rpr2 PF04032.16 ORX48845.1 - 6.4 7.1 11.8 0.41 11.0 2.5 2.6 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-CSL PF05207.13 ORX48845.1 - 6.6 6.5 12.5 2.2 8.1 2.3 3.1 2 2 0 2 2 2 0 CSL zinc finger Rubredoxin PF00301.20 ORX48845.1 - 7.1 6.7 9.9 28 4.8 0.5 3.5 4 0 0 4 4 3 0 Rubredoxin PMT PF02366.18 ORX48846.1 - 7.5e-75 251.7 23.5 7.5e-75 251.7 23.5 1.8 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX48846.1 - 2.3e-54 184.0 12.0 2.3e-54 184.0 12.0 2.6 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX48846.1 - 7e-05 22.8 0.1 0.00017 21.5 0.1 1.6 1 0 0 1 1 1 1 MIR domain EI24 PF07264.11 ORX48847.1 - 2.7e-09 37.5 8.4 5.1e-06 26.9 0.8 2.1 2 0 0 2 2 2 2 Etoposide-induced protein 2.4 (EI24) PhoR PF11808.8 ORX48847.1 - 0.016 15.6 1.4 0.016 15.6 1.4 2.4 3 0 0 3 3 3 0 Phosphate regulon sensor protein PhoR BolA PF01722.18 ORX48848.1 - 1e-15 57.7 0.1 2.3e-15 56.6 0.1 1.5 1 1 0 1 1 1 1 BolA-like protein E1_DerP2_DerF2 PF02221.15 ORX48849.1 - 2.2e-23 83.1 0.1 3e-23 82.7 0.1 1.1 1 0 0 1 1 1 1 ML domain Alph_Pro_TM PF09608.10 ORX48849.1 - 0.021 14.7 0.0 0.03 14.2 0.0 1.2 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) Biopterin_H PF00351.21 ORX48850.1 - 1.9e-166 553.1 0.0 2.3e-166 552.8 0.0 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 ORX48850.1 - 1.3e-05 24.8 0.0 2.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 ACT domain Chlor_dismutase PF06778.12 ORX48850.1 - 0.099 12.2 0.1 0.31 10.6 0.0 1.8 1 1 1 2 2 2 0 Chlorite dismutase ACT_4 PF13291.6 ORX48850.1 - 0.15 12.7 0.0 0.28 11.8 0.0 1.5 1 0 0 1 1 1 0 ACT domain GARP PF16731.5 ORX48850.1 - 0.17 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma RabGAP-TBC PF00566.18 ORX48851.1 - 3.4e-52 177.2 0.7 5.4e-52 176.6 0.7 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SH3_2 PF07653.17 ORX48851.1 - 0.065 12.9 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain zf-C2H2_jaz PF12171.8 ORX48852.1 - 0.026 14.8 2.8 0.037 14.3 0.8 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ORX48852.1 - 1.2 9.7 5.7 0.32 11.5 1.0 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Pkinase PF00069.25 ORX48853.1 - 2.7e-80 269.5 0.0 1.6e-33 116.2 0.1 4.3 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48853.1 - 4.2e-44 150.8 0.0 3.4e-16 59.3 0.0 4.4 4 0 0 4 4 4 4 Protein tyrosine kinase HGTP_anticodon2 PF12745.7 ORX48853.1 - 2.6e-36 125.5 3.4 2.6e-36 125.5 3.4 2.1 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs RWD PF05773.22 ORX48853.1 - 9.1e-18 64.6 0.1 2.9e-17 63.0 0.1 2.0 1 0 0 1 1 1 1 RWD domain tRNA-synt_His PF13393.6 ORX48853.1 - 4.2e-15 55.8 0.1 1.5e-14 54.0 0.0 1.9 2 0 0 2 2 2 1 Histidyl-tRNA synthetase Kinase-like PF14531.6 ORX48853.1 - 8.2e-06 25.3 0.0 0.045 13.0 0.0 2.9 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 ORX48853.1 - 5.4e-05 23.2 1.1 0.00032 20.7 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 ORX48853.1 - 0.0013 18.4 0.0 0.99 9.0 0.1 3.4 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Seadorna_VP7 PF07387.11 ORX48853.1 - 0.0032 16.6 0.9 1.7 7.6 0.0 3.6 4 0 0 4 4 4 2 Seadornavirus VP7 Kdo PF06293.14 ORX48853.1 - 0.0047 16.3 0.4 1 8.7 0.1 3.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family CAF1A PF12253.8 ORX48855.1 - 9.3e-26 89.8 4.4 9.3e-26 89.8 4.4 1.8 3 0 0 3 3 3 1 Chromatin assembly factor 1 subunit A Complex1_LYR PF05347.15 ORX48856.1 - 2e-08 34.2 0.3 3.1e-08 33.6 0.3 1.3 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX48856.1 - 2.7e-05 24.8 0.5 4.2e-05 24.2 0.5 1.3 1 0 0 1 1 1 1 Complex1_LYR-like MSC PF09402.10 ORX48856.1 - 0.017 14.6 0.1 0.02 14.4 0.1 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Metallophos PF00149.28 ORX48858.1 - 6e-12 46.5 2.0 1.2e-11 45.5 2.1 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX48858.1 - 0.0018 18.5 0.1 0.11 12.6 0.1 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain zf-C2H2_2 PF12756.7 ORX48859.1 - 0.00055 20.2 6.5 0.0012 19.1 6.5 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 ORX48859.1 - 0.013 15.2 1.8 0.013 15.2 1.8 2.3 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 ORX48859.1 - 3.5 8.7 11.8 10 7.2 3.0 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger Plasmid_stab_B PF10784.9 ORX48860.1 - 0.00067 19.4 4.6 29 4.6 0.0 5.5 1 1 5 6 6 6 3 Plasmid stability protein PEMT PF04191.13 ORX48860.1 - 0.044 14.2 5.3 21 5.5 0.2 3.4 1 1 3 4 4 4 0 Phospholipid methyltransferase Plasmid_stab_B PF10784.9 ORX48861.1 - 0.0012 18.6 3.7 13 5.7 0.1 4.9 1 1 5 6 6 6 3 Plasmid stability protein PEMT PF04191.13 ORX48861.1 - 0.46 10.9 4.4 69 3.9 0.1 3.3 1 1 4 5 5 5 0 Phospholipid methyltransferase E1-E2_ATPase PF00122.20 ORX48862.1 - 1.8e-41 141.7 0.3 1.8e-41 141.7 0.3 2.4 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX48862.1 - 1.9e-38 132.0 12.0 1.9e-38 132.0 12.0 2.4 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX48862.1 - 7.2e-22 77.3 0.0 1.8e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX48862.1 - 2.8e-19 70.2 0.0 7.2e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX48862.1 - 1.5e-06 27.8 0.0 3.7e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX48862.1 - 0.0048 16.7 0.6 0.012 15.3 0.6 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase M20_dimer PF07687.14 ORX48863.1 - 1.6e-08 34.4 0.0 4.1e-08 33.1 0.0 1.7 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX48863.1 - 1e-07 31.9 0.1 1.6e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Asp PF00026.23 ORX48864.1 - 3.9e-56 190.8 15.7 1.3e-55 189.1 15.7 1.7 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX48864.1 - 9.8e-07 29.2 6.8 0.0057 16.9 2.0 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX48864.1 - 6.3e-06 26.8 6.3 0.00037 21.1 1.1 2.8 3 0 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX48864.1 - 0.00024 21.6 2.6 0.003 18.1 0.1 3.0 2 1 0 2 2 2 1 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 ORX48864.1 - 0.0034 17.2 0.2 0.79 9.5 0.2 2.6 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal G-patch PF01585.23 ORX48865.1 - 5.5e-07 29.4 1.0 1.2e-06 28.2 1.0 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX48865.1 - 0.0078 16.3 0.0 0.0078 16.3 0.0 2.4 2 0 0 2 2 2 1 G-patch domain Kelch_5 PF13854.6 ORX48866.1 - 5.5e-07 29.4 0.2 0.00047 20.1 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ORX48866.1 - 1.2e-05 25.2 1.2 0.0049 16.8 0.1 3.1 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48866.1 - 3e-05 24.1 2.4 0.0072 16.6 0.3 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ORX48866.1 - 6.7e-05 23.1 0.3 0.0018 18.5 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX48866.1 - 0.00012 21.6 0.4 0.00027 20.5 0.2 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ORX48866.1 - 0.00073 19.4 1.2 0.006 16.5 0.1 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ORX48867.1 - 1.1e-16 60.1 0.4 4.4e-06 26.2 0.1 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 ORX48867.1 - 2.5e-13 49.9 0.2 3.9e-07 30.2 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX48867.1 - 8.3e-13 48.1 0.2 4.9e-06 26.6 0.1 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ORX48867.1 - 1.5e-11 44.1 0.3 2.9e-07 30.4 0.1 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX48867.1 - 1.5e-07 31.1 0.7 0.0019 18.1 0.0 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ORX48867.1 - 3.5e-07 30.1 0.1 0.07 13.1 0.1 3.8 3 0 0 3 3 3 3 Kelch motif DUF1970 PF09301.10 ORX48867.1 - 4.6 7.5 6.3 16 5.8 0.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1970) Sas10_Utp3 PF04000.15 ORX48868.1 - 1.5e-13 51.2 0.6 1.5e-13 51.2 0.6 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family eIF-3c_N PF05470.12 ORX48868.1 - 0.067 11.5 5.3 0.077 11.3 5.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus RRM_1 PF00076.22 ORX48869.1 - 3.1e-32 110.2 0.0 1.5e-14 53.6 0.0 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX48869.1 - 7.7e-05 22.7 0.0 0.0032 17.5 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif RRM_occluded PF16842.5 ORX48869.1 - 0.00019 21.2 0.0 0.064 13.1 0.0 3.1 3 1 0 3 3 3 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ORX48869.1 - 0.035 14.1 0.1 1.8 8.6 0.0 2.7 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif DUF3887 PF13026.6 ORX48869.1 - 0.039 14.8 0.3 0.11 13.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3887) DUF202 PF02656.15 ORX48870.1 - 5.9e-05 23.4 4.7 5.9e-05 23.4 4.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF2721 PF11026.8 ORX48870.1 - 0.015 15.2 0.1 0.015 15.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Big_3_4 PF13754.6 ORX48870.1 - 0.065 13.0 0.0 0.14 11.9 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function Myelin_PLP PF01275.19 ORX48870.1 - 0.091 12.6 3.9 0.1 12.4 3.9 1.1 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) VPDSG-CTERM PF18205.1 ORX48870.1 - 1.3 9.0 10.1 0.12 12.2 3.3 2.4 2 0 0 2 2 2 0 VPDSG-CTERM motif PEP-CTERM PF07589.11 ORX48870.1 - 6.2 7.1 6.8 1.4 9.1 2.4 2.1 2 0 0 2 2 2 0 PEP-CTERM motif DUF4078 PF13300.6 ORX48871.1 - 2.1e-18 66.4 6.0 2.1e-18 66.4 6.0 2.2 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) DNA_ligase_A_C PF04679.15 ORX48871.1 - 0.005 17.4 0.9 0.44 11.2 0.1 2.2 2 0 0 2 2 2 2 ATP dependent DNA ligase C terminal region SPAM PF02090.15 ORX48871.1 - 0.022 14.6 0.2 0.022 14.6 0.2 2.1 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein HSP70 PF00012.20 ORX48872.1 - 3.6e-97 326.0 4.0 4.2e-97 325.8 4.0 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX48872.1 - 1.6e-14 53.5 3.3 1.6e-13 50.2 3.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein DUF3453 PF11935.8 ORX48873.1 - 1.4e-24 87.0 7.1 1.6e-24 86.8 0.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF3453) HEAT PF02985.22 ORX48873.1 - 1.7e-05 24.7 5.4 0.76 10.2 0.2 5.3 4 1 1 5 5 5 3 HEAT repeat TPR_22 PF18833.1 ORX48873.1 - 0.0082 16.3 0.3 0.042 14.0 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat ChAPs PF09295.10 ORX48873.1 - 0.024 13.6 0.0 0.045 12.7 0.0 1.4 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) CDC24_OB3 PF17244.2 ORX48874.1 - 1.3e-32 113.3 0.8 9.4e-31 107.3 0.0 2.2 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 tRNA_anti-codon PF01336.25 ORX48874.1 - 2.6e-05 24.1 0.0 6e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain POT1PC PF16686.5 ORX48874.1 - 5.6e-05 23.1 0.1 0.11 12.4 0.0 3.3 1 1 2 3 3 3 2 ssDNA-binding domain of telomere protection protein CDC24_OB2 PF17245.2 ORX48874.1 - 8.7e-05 23.1 0.1 0.00021 21.8 0.1 1.7 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 2 DUF4758 PF15950.5 ORX48874.1 - 0.6 10.5 2.1 19 5.6 0.2 2.7 2 1 0 2 2 2 0 Putative sperm flagellar membrane protein DUF3808 PF10300.9 ORX48875.1 - 3.3e-62 210.8 8.0 3.1e-38 131.8 1.0 2.5 3 0 0 3 3 3 2 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX48875.1 - 0.00089 19.2 3.5 1.2 9.4 1.4 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX48875.1 - 0.008 16.3 2.0 2.6 8.5 0.8 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX48875.1 - 0.03 15.0 1.7 24 5.9 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX48875.1 - 0.068 13.5 4.1 1 9.7 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Nramp PF01566.18 ORX48876.1 - 4.7e-107 358.1 27.8 5.1e-48 163.9 9.6 3.2 3 0 0 3 3 3 3 Natural resistance-associated macrophage protein PMT PF02366.18 ORX48877.1 - 3.6e-78 262.5 17.5 3.6e-78 262.5 17.5 2.0 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX48877.1 - 1.7e-59 200.8 17.8 1.7e-59 200.8 17.8 2.8 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX48877.1 - 3.2e-26 92.3 0.1 5.8e-26 91.5 0.1 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ORX48877.1 - 0.00076 19.7 12.6 0.00076 19.7 12.6 3.3 4 0 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase zf-RING_2 PF13639.6 ORX48878.1 - 1.9e-12 47.3 9.0 3.8e-12 46.3 9.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX48878.1 - 9.3e-11 41.3 1.7 2.7e-10 39.8 1.7 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX48878.1 - 3e-09 36.6 5.6 6.5e-09 35.5 5.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX48878.1 - 1.8e-08 34.1 10.0 3.2e-08 33.3 10.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 ORX48878.1 - 3.5e-07 30.1 0.0 7.1e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 ORX48878.1 - 2.5e-06 27.7 10.4 1.3e-05 25.4 10.4 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX48878.1 - 2.7e-06 27.2 8.1 4.6e-06 26.5 8.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX48878.1 - 5.7e-05 23.1 3.7 0.00022 21.2 3.8 2.0 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX48878.1 - 7.1e-05 22.6 6.2 0.00014 21.7 6.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX48878.1 - 0.00017 21.3 4.1 0.00033 20.5 4.1 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX48878.1 - 0.0021 18.1 6.8 0.008 16.2 5.7 2.3 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ORX48878.1 - 0.0083 16.2 1.6 0.025 14.7 1.6 1.9 1 1 0 1 1 1 1 RING-variant domain PHD PF00628.29 ORX48878.1 - 0.021 14.7 7.4 0.038 13.9 7.4 1.4 1 0 0 1 1 1 0 PHD-finger zf-C3H2C3 PF17122.5 ORX48878.1 - 0.045 13.8 4.0 0.16 12.1 4.0 1.9 1 1 0 1 1 1 0 Zinc-finger zf-RING-like PF08746.11 ORX48878.1 - 0.056 13.8 2.5 0.056 13.8 2.5 1.7 2 0 0 2 2 1 0 RING-like domain AvrL567-A PF11529.8 ORX48878.1 - 0.073 13.3 0.0 0.19 12.0 0.0 1.6 1 1 1 2 2 2 0 Melampsora lini avirulence protein AvrL567-A Zn_ribbon_17 PF17120.5 ORX48878.1 - 0.28 10.8 4.9 0.67 9.6 4.9 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_4 PF14570.6 ORX48878.1 - 1.8 8.4 8.3 4 7.3 8.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Pkinase PF00069.25 ORX48879.1 - 3.6e-40 138.0 0.0 7e-27 94.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX48879.1 - 5.6e-19 68.4 0.0 2.9e-11 43.2 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Methyltransf_4 PF02390.17 ORX48880.1 - 3.8e-58 195.8 0.0 4.6e-58 195.5 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 ORX48880.1 - 0.00043 20.9 0.0 0.0024 18.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ORX48880.1 - 0.0014 18.2 0.0 0.0093 15.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ORX48880.1 - 0.014 15.2 0.0 0.025 14.4 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ORX48880.1 - 0.03 15.0 0.0 0.35 11.5 0.0 2.6 2 1 0 2 2 2 0 Methyltransferase domain Glyco_transf_22 PF03901.17 ORX48881.1 - 6.2e-88 295.8 27.3 7.6e-88 295.5 27.3 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PhaP_Bmeg PF09602.10 ORX48882.1 - 0.0047 16.9 0.0 0.16 11.9 0.0 2.3 2 0 0 2 2 2 2 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) ERCC4 PF02732.15 ORX49045.1 - 1.7e-08 34.8 0.7 1.7e-08 34.8 0.7 2.0 1 1 1 2 2 2 1 ERCC4 domain GBP_C PF02841.14 ORX49045.1 - 0.033 13.6 9.2 0.07 12.5 9.2 1.5 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Ctr PF04145.15 ORX49045.1 - 1.2 9.7 5.2 12 6.5 0.6 2.4 2 0 0 2 2 2 0 Ctr copper transporter family DUF2956 PF11169.8 ORX49045.1 - 3.4 7.9 13.5 6.5 7.0 5.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Peptidase_S49_N PF08496.10 ORX49045.1 - 4.3 7.4 10.0 1.6 8.8 6.1 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Agouti PF05039.12 ORX49045.1 - 4.6 8.0 5.8 21 5.9 5.8 2.1 1 0 0 1 1 1 0 Agouti protein AIF_C PF14721.6 ORX49045.1 - 9.5 6.6 7.4 0.64 10.4 2.0 1.9 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Pam16 PF03656.13 ORX49046.1 - 1.3e-31 109.2 1.9 1.6e-31 108.9 1.9 1.1 1 0 0 1 1 1 1 Pam16 Voltage_CLC PF00654.20 ORX49047.1 - 1.5e-89 300.7 24.5 1.5e-89 300.7 24.5 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ORX49047.1 - 1.2e-05 25.7 0.0 3.6e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 CBS domain TAT_signal PF10518.9 ORX49047.1 - 0.56 10.2 10.7 0.1 12.5 0.5 2.9 2 0 0 2 2 2 0 TAT (twin-arginine translocation) pathway signal sequence WD40 PF00400.32 ORX49048.1 - 1.5e-23 82.6 2.8 0.00073 20.3 0.0 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX49048.1 - 1.3e-12 47.9 0.0 1.4e-06 28.5 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX49048.1 - 4.2e-06 26.3 0.0 7.3e-06 25.5 0.0 1.4 1 1 0 1 1 1 1 WD40-like domain eIF2A PF08662.11 ORX49048.1 - 0.00011 22.2 0.1 0.019 14.8 0.0 3.0 1 1 3 4 4 4 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX49048.1 - 0.019 13.9 0.2 9.4 5.1 0.0 3.2 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX49048.1 - 0.023 13.3 0.0 0.06 12.0 0.0 1.7 2 0 0 2 2 2 0 Nucleoporin Nup120/160 ABC_membrane PF00664.23 ORX49049.1 - 2e-51 175.3 34.5 1.2e-32 113.6 13.7 3.3 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX49049.1 - 2.3e-46 157.7 0.0 1.8e-27 96.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX49049.1 - 9.3e-12 44.9 0.0 3.2e-05 23.5 0.0 4.1 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ORX49049.1 - 1.5e-05 25.3 0.9 0.48 10.7 0.0 3.4 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.6 ORX49049.1 - 0.00016 22.2 2.7 0.15 12.5 0.1 2.6 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX49049.1 - 0.00017 20.8 0.1 0.56 9.2 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 ORX49049.1 - 0.00042 20.0 0.2 0.24 11.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX49049.1 - 0.0053 16.7 0.3 1.5 8.7 0.1 2.6 2 0 0 2 2 2 1 RsgA GTPase NB-ARC PF00931.22 ORX49049.1 - 0.0066 15.7 0.1 1 8.5 0.5 2.9 2 2 0 2 2 2 1 NB-ARC domain AAA_21 PF13304.6 ORX49049.1 - 0.0071 16.2 0.1 5 6.9 0.1 3.4 2 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX49049.1 - 0.0097 16.3 0.0 5.2 7.4 0.0 2.7 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX49049.1 - 0.014 15.5 0.0 0.42 10.7 0.0 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX49049.1 - 0.02 14.6 0.9 1.6 8.5 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain ATPase PF06745.13 ORX49049.1 - 0.024 14.0 0.2 2.4 7.5 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_15 PF13175.6 ORX49049.1 - 0.032 13.9 0.0 3.4 7.3 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain Pox_A32 PF04665.12 ORX49049.1 - 0.044 13.2 0.0 1.3 8.5 0.0 2.4 2 0 0 2 2 2 0 Poxvirus A32 protein DUF87 PF01935.17 ORX49049.1 - 0.052 13.6 0.6 2.5 8.2 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_18 PF13238.6 ORX49049.1 - 0.061 13.9 0.0 7 7.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 ORX49049.1 - 0.087 12.8 0.3 4.7 7.2 0.0 2.9 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ORX49049.1 - 0.1 11.8 0.5 0.65 9.2 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 ORX49049.1 - 0.11 12.3 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 IstB-like ATP binding protein DEAD PF00270.29 ORX49049.1 - 0.11 12.3 0.3 7.1 6.4 0.0 3.1 3 0 0 3 3 3 0 DEAD/DEAH box helicase Dynamin_N PF00350.23 ORX49049.1 - 0.11 12.5 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Dynamin family Viral_helicase1 PF01443.18 ORX49049.1 - 0.13 12.0 0.1 18 5.0 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 ORX49049.1 - 0.14 12.6 0.4 14 6.1 0.0 3.2 4 0 0 4 4 3 0 RNA helicase CbiA PF01656.23 ORX49049.1 - 0.16 12.0 0.6 3.4 7.7 0.0 3.0 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain NACHT PF05729.12 ORX49049.1 - 1.6 8.6 4.0 18 5.2 0.2 2.7 3 0 0 3 3 2 0 NACHT domain ABC_membrane PF00664.23 ORX49051.1 - 1e-56 192.6 23.7 3.4e-36 125.3 9.5 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX49051.1 - 5.7e-45 153.2 0.0 4.5e-24 85.5 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX49051.1 - 6.7e-12 45.3 0.1 2.3e-05 23.9 0.0 4.1 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 ORX49051.1 - 1.3e-06 28.1 1.1 0.0018 17.9 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ORX49051.1 - 6e-06 26.6 2.7 0.091 13.0 0.0 3.5 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX49051.1 - 1.9e-05 23.8 0.1 0.02 14.0 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_23 PF13476.6 ORX49051.1 - 0.00027 21.5 0.8 0.15 12.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX49051.1 - 0.0004 20.1 4.6 0.028 14.1 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX49051.1 - 0.00047 20.1 0.2 3.9 7.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX49051.1 - 0.00053 19.9 0.1 0.2 11.6 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ORX49051.1 - 0.00058 20.3 0.3 1.5 9.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_18 PF13238.6 ORX49051.1 - 0.0015 19.1 0.0 3.6 8.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 ORX49051.1 - 0.0036 17.4 0.1 0.42 10.7 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase IstB_IS21 PF01695.17 ORX49051.1 - 0.004 16.9 0.0 9 6.0 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein NB-ARC PF00931.22 ORX49051.1 - 0.0046 16.2 0.7 2.4 7.3 1.1 3.5 3 1 0 3 3 3 1 NB-ARC domain AAA_7 PF12775.7 ORX49051.1 - 0.0058 16.2 0.2 2 7.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 ORX49051.1 - 0.0083 16.5 0.0 3.3 8.1 0.0 3.2 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) DUF87 PF01935.17 ORX49051.1 - 0.011 15.9 3.6 1.7 8.7 0.3 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain NACHT PF05729.12 ORX49051.1 - 0.011 15.6 1.5 1.1 9.2 0.0 3.0 3 0 0 3 3 3 0 NACHT domain Pox_A32 PF04665.12 ORX49051.1 - 0.011 15.2 1.5 1.3 8.4 0.0 2.5 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_24 PF13479.6 ORX49051.1 - 0.014 15.2 1.8 1.4 8.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 ORX49051.1 - 0.023 14.7 0.5 2.3 8.3 0.0 3.1 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_5 PF07728.14 ORX49051.1 - 0.024 14.6 0.6 24 4.9 0.0 3.8 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX49051.1 - 0.024 14.8 2.1 0.76 9.9 0.3 2.7 3 0 0 3 3 2 0 AAA domain AAA_14 PF13173.6 ORX49051.1 - 0.041 13.9 0.0 18 5.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 ORX49051.1 - 0.046 13.1 0.5 3.3 7.0 0.0 2.4 2 0 0 2 2 2 0 KaiC AAA_11 PF13086.6 ORX49051.1 - 0.05 13.4 0.0 0.99 9.1 0.0 2.8 3 0 0 3 3 3 0 AAA domain RNA_helicase PF00910.22 ORX49051.1 - 0.059 13.8 0.8 8.3 6.9 0.1 2.9 3 0 0 3 3 2 0 RNA helicase DEAD PF00270.29 ORX49051.1 - 0.061 13.1 1.3 6.9 6.4 0.0 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 ORX49051.1 - 0.063 13.0 0.1 12 5.6 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Roc PF08477.13 ORX49051.1 - 0.097 12.9 0.2 23 5.2 0.1 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ORX49051.1 - 0.1 12.7 0.7 0.69 10.0 0.0 2.3 2 0 0 2 2 2 0 Dynamin family AAA_15 PF13175.6 ORX49051.1 - 0.1 12.3 0.0 4.1 7.0 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain NTPase_1 PF03266.15 ORX49051.1 - 0.18 11.7 0.9 14 5.6 0.1 2.7 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 ORX49051.1 - 0.19 11.4 0.1 5.3 6.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX49051.1 - 0.21 10.9 0.8 1 8.6 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Polyoma_lg_T_C PF06431.11 ORX49051.1 - 0.5 9.2 1.8 21 3.8 0.3 2.7 3 0 0 3 3 3 0 Polyomavirus large T antigen C-terminus ATP_bind_1 PF03029.17 ORX49051.1 - 0.63 9.8 4.4 11 5.8 0.1 3.4 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 ORX49051.1 - 0.71 9.6 2.7 14 5.4 0.3 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ORX49051.1 - 0.72 9.4 4.0 0.31 10.6 0.4 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_membrane PF00664.23 ORX49052.1 - 3.1e-46 158.2 27.7 5.8e-29 101.6 10.8 3.6 2 2 1 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX49052.1 - 3.5e-41 140.9 0.0 1.2e-20 74.4 0.0 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX49052.1 - 9e-08 31.8 0.0 0.0074 15.7 0.0 3.3 2 2 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 ORX49052.1 - 0.00048 19.8 1.0 0.028 14.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ORX49052.1 - 0.00074 19.8 0.1 0.25 11.6 0.0 3.1 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 ORX49052.1 - 0.0027 17.6 0.0 0.084 12.8 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ORX49052.1 - 0.012 15.3 0.6 0.27 11.0 0.1 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX49052.1 - 0.021 14.6 0.0 8.4 6.1 0.0 3.2 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 ORX49052.1 - 0.025 14.7 0.0 0.84 9.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ORX49052.1 - 0.034 14.5 0.0 16 5.9 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain T2SSE PF00437.20 ORX49052.1 - 0.035 13.1 0.2 0.32 10.0 0.0 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_18 PF13238.6 ORX49052.1 - 0.048 14.2 0.0 5.5 7.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ORX49052.1 - 0.078 13.5 4.2 0.091 13.3 0.3 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX49052.1 - 0.15 11.8 0.2 3.3 7.4 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_11 PF13086.6 ORX49052.1 - 0.2 11.4 0.0 1.6 8.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain EF-hand_6 PF13405.6 ORX49052.1 - 0.24 11.4 0.5 0.65 10.1 0.5 1.7 1 0 0 1 1 1 0 EF-hand domain PUF PF00806.19 ORX49053.1 - 3.1e-25 86.4 0.1 0.0002 20.9 0.0 6.1 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat RRM_1 PF00076.22 ORX49053.1 - 1.9e-24 85.3 0.0 3.6e-12 45.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nab6_mRNP_bdg PF10567.9 ORX49053.1 - 0.00018 21.1 0.0 0.04 13.4 0.0 2.2 2 0 0 2 2 2 2 RNA-recognition motif RRM_occluded PF16842.5 ORX49053.1 - 0.088 12.7 0.0 1 9.2 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif DUF2057 PF09829.9 ORX49053.1 - 4.4 7.4 6.9 0.23 11.6 0.4 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) Pkinase PF00069.25 ORX49054.1 - 4.3e-54 183.6 0.8 3.1e-52 177.5 0.8 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49054.1 - 6.2e-26 91.2 0.0 1e-25 90.5 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49054.1 - 1.6e-14 53.9 0.0 2.4e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ORX49054.1 - 1.2e-05 25.0 0.4 2.2e-05 24.2 0.4 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ORX49054.1 - 1.8e-05 24.8 0.0 0.00025 21.0 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX49054.1 - 3.3e-05 22.8 0.9 5.9e-05 22.0 0.1 1.6 2 0 0 2 2 2 1 Fungal protein kinase Seadorna_VP7 PF07387.11 ORX49054.1 - 4.2e-05 22.8 0.4 7.5e-05 21.9 0.4 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 ORX49054.1 - 0.0002 20.8 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX49054.1 - 0.00029 19.9 0.5 0.00051 19.1 0.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain LepB_N PF18640.1 ORX49054.1 - 0.02 14.5 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 LepB N-terminal domain PIP49_C PF12260.8 ORX49054.1 - 0.083 12.5 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Choline_kinase PF01633.20 ORX49054.1 - 0.094 12.3 0.2 0.22 11.1 0.2 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase FTR1 PF03239.14 ORX49055.1 - 7.1e-69 232.3 15.6 8.7e-69 232.0 15.6 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family MnhB PF04039.13 ORX49055.1 - 0.00079 19.7 11.2 0.0079 16.5 2.3 2.7 3 0 0 3 3 3 2 Domain related to MnhB subunit of Na+/H+ antiporter WD40 PF00400.32 ORX49056.1 - 7.6e-14 51.9 7.5 1.7e-06 28.6 0.3 6.2 5 0 0 5 5 5 2 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 ORX49056.1 - 8.5e-09 34.9 12.9 2.5e-08 33.4 12.9 1.9 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type ANAPC4_WD40 PF12894.7 ORX49056.1 - 3.3e-06 27.3 0.1 0.19 12.0 0.0 4.2 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX49056.1 - 6.2e-05 23.0 0.0 0.65 9.8 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Rep_fac-A_C PF08646.10 ORX49056.1 - 0.21 11.3 1.4 0.47 10.2 1.4 1.5 1 0 0 1 1 1 0 Replication factor-A C terminal domain zinc_ribbon_16 PF17034.5 ORX49056.1 - 2.3 8.5 16.5 0.27 11.4 6.0 2.5 1 1 1 2 2 2 0 Zinc-ribbon like family FTR1 PF03239.14 ORX49057.1 - 1.7e-67 227.7 14.5 3.6e-67 226.7 14.5 1.4 1 1 0 1 1 1 1 Iron permease FTR1 family Abhydrolase_9_N PF15420.6 ORX49057.1 - 0.023 14.7 1.1 0.023 14.7 1.1 1.7 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus DUF4579 PF15158.6 ORX49057.1 - 0.023 14.5 1.9 0.23 11.2 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4579) MgtE PF01769.16 ORX49057.1 - 1.4 9.3 17.2 1.9 8.9 4.6 2.7 3 0 0 3 3 3 0 Divalent cation transporter DUF2070 PF09843.9 ORX49057.1 - 2.3 6.4 8.1 0.36 9.1 0.9 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Cu-oxidase_3 PF07732.15 ORX49058.1 - 2e-38 131.1 7.5 1.5e-35 121.8 1.0 3.7 3 1 1 4 4 4 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX49058.1 - 1.1e-35 122.3 0.8 1.1e-35 122.3 0.8 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX49058.1 - 1.6e-33 116.1 5.7 2.4e-33 115.5 1.9 2.8 3 0 0 3 3 3 1 Multicopper oxidase AKAP7_NLS PF10469.9 ORX49059.1 - 2.4e-13 50.5 0.0 3.4e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX49059.1 - 0.00018 21.5 0.0 0.12 12.3 0.0 2.4 1 1 1 2 2 2 2 2'-5' RNA ligase superfamily UIM PF02809.20 ORX49061.1 - 0.014 15.2 1.7 0.014 15.2 1.7 1.9 2 0 0 2 2 2 0 Ubiquitin interaction motif OB_Dis3 PF17849.1 ORX49062.1 - 3e-05 23.9 0.1 4.5e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Jun PF03957.13 ORX49063.1 - 2.7 7.8 14.5 3 7.7 14.5 1.1 1 0 0 1 1 1 0 Jun-like transcription factor DUF2070 PF09843.9 ORX49063.1 - 8.6 4.5 7.2 9.6 4.4 7.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Rrp44_CSD1 PF17216.3 ORX49064.1 - 0.11 12.2 0.0 0.15 11.7 0.0 1.1 1 0 0 1 1 1 0 Rrp44-like cold shock domain OrfB_Zn_ribbon PF07282.11 ORX49066.1 - 8e-10 38.5 2.5 2e-09 37.2 2.5 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX49066.1 - 0.09 12.4 0.8 0.18 11.5 0.8 1.4 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Pox_Ag35 PF03286.14 ORX49066.1 - 8.1 6.2 9.4 0.65 9.8 0.2 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Rrp44_CSD1 PF17216.3 ORX49067.1 - 0.13 12.0 0.4 0.18 11.5 0.4 1.2 1 0 0 1 1 1 0 Rrp44-like cold shock domain OB_Dis3 PF17849.1 ORX49068.1 - 4e-18 65.2 0.0 5.2e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 ORX49068.1 - 0.0098 16.0 0.0 0.018 15.2 0.0 1.5 1 1 0 1 1 1 1 Cold shock domain Cu-oxidase_3 PF07732.15 ORX49069.1 - 6.8e-40 135.8 4.1 2.2e-37 127.7 0.3 3.4 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX49069.1 - 5.5e-37 126.6 5.8 3.8e-33 114.1 0.1 3.9 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX49069.1 - 3.5e-27 95.5 0.2 7.4e-26 91.2 0.1 2.3 2 0 0 2 2 2 1 Multicopper oxidase DUF4981 PF16353.5 ORX49069.1 - 0.025 15.1 0.0 3.8 8.1 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function(DUF4981) KH_1 PF00013.29 ORX49070.1 - 2.8e-07 30.2 0.3 0.00016 21.5 0.1 2.6 2 1 0 2 2 2 2 KH domain Sfi1_C PF10638.9 ORX49070.1 - 0.092 13.5 0.1 21 5.9 0.0 2.3 2 0 0 2 2 2 0 Spindle body associated protein C-terminus FYVE PF01363.21 ORX49071.1 - 1.1e-19 70.3 8.9 1.1e-19 70.3 8.9 2.0 2 0 0 2 2 2 1 FYVE zinc finger FYVE_2 PF02318.16 ORX49071.1 - 0.19 12.0 13.0 0.046 13.9 9.1 2.0 2 1 1 3 3 3 0 FYVE-type zinc finger HypA PF01155.19 ORX49071.1 - 1.6 8.8 9.6 3.5 7.7 5.3 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ORX49071.1 - 2.5 8.2 15.0 3.4e+03 -1.8 15.0 3.4 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ORX49071.1 - 3.1 8.0 18.7 5.4 7.2 0.2 3.7 3 2 1 4 4 4 0 Zinc ribbon domain IBR PF01485.21 ORX49071.1 - 7.2 6.9 12.9 75 3.7 0.1 3.3 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain F-box-like PF12937.7 ORX49072.1 - 1.1e-10 41.2 1.3 4.1e-10 39.4 1.3 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX49072.1 - 0.00035 20.4 2.3 0.0007 19.4 0.2 2.8 3 0 0 3 3 3 1 F-box domain F-box_4 PF15966.5 ORX49072.1 - 0.051 13.5 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 F-box Acetyltransf_1 PF00583.25 ORX49073.1 - 3e-13 50.0 0.0 3.8e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX49073.1 - 3.2e-08 33.9 0.1 4.5e-08 33.4 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX49073.1 - 6.5e-08 32.6 0.0 8.9e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX49073.1 - 8e-05 22.5 0.1 0.00016 21.6 0.1 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ORX49073.1 - 0.019 14.6 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX49073.1 - 0.12 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AAA_13 PF13166.6 ORX49074.1 - 0.0011 17.8 9.4 0.0011 17.8 9.4 3.5 2 1 0 3 3 3 1 AAA domain TPR_MLP1_2 PF07926.12 ORX49074.1 - 0.0018 18.3 4.4 0.0018 18.3 4.4 4.6 3 1 0 4 4 4 1 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 ORX49074.1 - 0.022 14.8 0.9 0.022 14.8 0.9 3.1 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus IL10 PF00726.17 ORX49074.1 - 0.77 9.3 5.3 3.7 7.0 0.4 2.7 2 0 0 2 2 2 0 Interleukin 10 CorA PF01544.18 ORX49074.1 - 8.3 5.6 22.8 2.1 7.6 2.4 3.3 1 1 3 4 4 4 0 CorA-like Mg2+ transporter protein PhoLip_ATPase_C PF16212.5 ORX49075.1 - 3.9e-73 246.3 30.6 3.9e-73 246.3 30.6 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX49075.1 - 8.3e-24 83.1 0.4 2.7e-23 81.4 0.4 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX49075.1 - 1.2e-14 54.2 0.0 4.5e-13 49.1 0.0 2.6 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX49075.1 - 7.7e-10 39.4 1.5 0.0051 17.1 0.0 3.5 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX49075.1 - 3e-06 26.9 0.0 3e-06 26.9 0.0 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX49075.1 - 0.00074 19.3 0.0 0.0034 17.2 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Rer1 PF03248.13 ORX49077.1 - 1.1e-80 269.3 9.0 1.3e-80 269.1 9.0 1.0 1 0 0 1 1 1 1 Rer1 family DUF2606 PF10794.9 ORX49077.1 - 0.2 11.4 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) DUF4191 PF13829.6 ORX49077.1 - 0.47 9.8 1.3 19 4.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) DUF2208 PF09973.9 ORX49077.1 - 1 8.9 9.4 0.12 12.0 2.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) DUF1189 PF06691.11 ORX49077.1 - 1.6 8.2 8.0 0.28 10.7 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1189) Frataxin_Cyay PF01491.16 ORX49078.1 - 4e-38 129.8 0.0 5.1e-38 129.5 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain Kelch_4 PF13418.6 ORX49079.1 - 1.7e-11 43.9 21.0 0.00016 21.6 0.1 6.2 6 1 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX49079.1 - 1.8e-08 34.2 14.4 0.026 14.5 0.1 5.6 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ORX49079.1 - 1.1e-05 25.6 13.7 0.037 14.3 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ORX49079.1 - 8.6e-05 22.7 22.9 0.11 12.8 0.1 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain NCU-G1 PF15065.6 ORX49079.1 - 0.0065 15.5 3.7 0.017 14.1 0.4 2.1 2 0 0 2 2 2 1 Lysosomal transcription factor, NCU-G1 Podoplanin PF05808.11 ORX49079.1 - 0.019 15.1 1.6 0.029 14.5 0.0 2.1 3 0 0 3 3 3 0 Podoplanin Kelch_1 PF01344.25 ORX49079.1 - 0.036 13.6 6.6 3.5 7.3 0.1 5.1 5 0 0 5 5 5 0 Kelch motif DUF202 PF02656.15 ORX49079.1 - 0.071 13.6 0.1 0.15 12.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF202) F-box-like PF12937.7 ORX49081.1 - 1.1e-08 34.8 0.5 3.1e-08 33.4 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX49081.1 - 2e-07 30.7 2.2 2.4e-07 30.4 0.5 2.1 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 ORX49081.1 - 0.0067 16.3 0.3 0.014 15.3 0.1 1.8 2 0 0 2 2 2 1 F-box Lum_binding PF00677.17 ORX49082.1 - 6.9e-46 154.2 0.7 6.8e-23 80.5 0.2 2.1 2 0 0 2 2 2 2 Lumazine binding domain Gifsy-2 PF13856.6 ORX49082.1 - 0.0092 16.3 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 ATP-binding sugar transporter from pro-phage Med10 PF09748.9 ORX49083.1 - 1.6e-19 70.0 0.0 2.2e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex zf-CCCH_2 PF14608.6 ORX49084.1 - 3.4e-15 55.9 62.5 0.00014 22.2 2.9 5.4 5 0 0 5 5 5 4 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ORX49084.1 - 0.035 14.3 8.5 0.49 10.6 0.2 3.1 3 0 0 3 3 3 0 Zinc-finger containing family YidD PF01809.18 ORX49084.1 - 0.041 13.8 5.6 0.23 11.4 0.2 3.3 3 0 0 3 3 3 0 Putative membrane protein insertion efficiency factor SPX PF03105.19 ORX49084.1 - 1.3 8.8 8.8 1.7 8.4 8.8 1.2 1 0 0 1 1 1 0 SPX domain SelP_N PF04592.14 ORX49084.1 - 1.8 7.9 6.3 3.3 7.0 6.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Pkinase PF00069.25 ORX49085.1 - 1.7e-74 250.5 0.0 2.1e-74 250.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49085.1 - 1e-39 136.4 0.0 1.3e-39 136.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49085.1 - 3.7e-06 26.5 0.0 5.2e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX49085.1 - 0.079 12.9 0.2 2.9 7.8 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX49085.1 - 0.094 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Sugar_tr PF00083.24 ORX49086.1 - 8.5e-97 324.9 27.8 4.8e-96 322.4 27.8 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX49086.1 - 4.7e-31 108.0 33.9 4.8e-24 85.0 11.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX49086.1 - 1.5e-05 23.8 33.4 0.0012 17.5 11.2 3.3 2 1 1 3 3 3 3 MFS/sugar transport protein Ank_4 PF13637.6 ORX49087.1 - 1.3e-18 67.1 0.8 1e-12 48.3 0.4 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX49087.1 - 1.3e-15 57.7 0.3 2.2e-08 34.5 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ORX49087.1 - 3.6e-14 52.5 0.6 2.2e-05 24.7 0.2 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ORX49087.1 - 2.9e-10 39.5 0.3 7.6e-05 22.8 0.1 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX49087.1 - 1.8e-07 31.3 0.2 0.0019 18.5 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.13 ORX49087.1 - 2.1e-07 30.8 2.9 4.3e-07 29.8 0.2 2.6 2 1 0 2 2 2 1 KilA-N domain Bap31_Bap29_C PF18035.1 ORX49087.1 - 6.6 6.8 5.5 7.8 6.6 0.4 2.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Ras PF00071.22 ORX49088.1 - 1.2e-58 197.3 0.1 1.3e-58 197.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX49088.1 - 2.7e-36 124.4 0.0 4e-36 123.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX49088.1 - 1.2e-18 67.2 0.0 1.5e-18 66.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX49088.1 - 2.3e-07 30.4 0.0 2.9e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX49088.1 - 6.6e-07 29.4 0.0 2.1e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX49088.1 - 6e-06 25.9 0.1 8.8e-06 25.4 0.1 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX49088.1 - 1.4e-05 25.6 0.1 2e-05 25.1 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX49088.1 - 4e-05 23.6 0.2 0.32 10.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ORX49088.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.9 1 1 0 1 1 1 0 AAA domain Mito_fiss_Elm1 PF06258.11 ORX49088.1 - 0.12 11.5 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 CENP-X PF09415.10 ORX49089.1 - 1e-22 80.2 0.3 1.1e-22 80.1 0.3 1.0 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 ORX49089.1 - 4.7e-06 26.8 1.5 5.3e-06 26.6 1.5 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2584 PF10763.9 ORX49089.1 - 0.078 13.1 0.0 0.1 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2584) S1FA PF04689.13 ORX49090.1 - 0.093 12.9 1.8 3.1 8.0 0.0 2.5 2 0 0 2 2 2 0 DNA binding protein S1FA LTV PF04180.14 ORX49091.1 - 7.8e-82 276.0 52.0 3e-80 270.8 27.7 2.7 1 1 2 3 3 3 2 Low temperature viability protein PorA PF11271.8 ORX49091.1 - 0.032 13.5 1.0 0.093 12.0 1.0 1.7 1 0 0 1 1 1 0 Porin PorA NUDIX PF00293.28 ORX49092.1 - 3.8e-10 39.9 0.0 7.7e-10 38.9 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain EphA2_TM PF14575.6 ORX49093.1 - 0.00042 21.1 0.1 0.00072 20.4 0.1 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain VSP PF03302.13 ORX49093.1 - 0.013 14.4 1.0 0.025 13.5 1.0 1.4 1 0 0 1 1 1 0 Giardia variant-specific surface protein DUF2613 PF11021.8 ORX49093.1 - 0.017 15.2 2.3 0.08 13.1 2.3 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) Amnionless PF14828.6 ORX49093.1 - 0.027 13.3 0.0 0.039 12.8 0.0 1.2 1 0 0 1 1 1 0 Amnionless CYYR1 PF10873.8 ORX49093.1 - 0.044 14.2 0.1 0.087 13.3 0.1 1.4 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 SKG6 PF08693.10 ORX49093.1 - 0.34 10.4 6.0 1.1 8.7 6.0 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Podoplanin PF05808.11 ORX49093.1 - 1.2 9.2 7.0 0.096 12.8 0.8 2.3 2 1 0 2 2 2 0 Podoplanin DAP10 PF07213.11 ORX49093.1 - 2.3 8.2 4.5 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 DAP10 membrane protein Pkinase PF00069.25 ORX49094.1 - 1.4e-18 67.2 0.0 1.8e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49094.1 - 4.3e-08 32.8 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49094.1 - 0.0064 15.9 0.0 0.009 15.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like zf-C2H2 PF00096.26 ORX49095.1 - 2.4 8.8 10.1 2.1 9.0 6.5 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 ORX49095.1 - 5.8 7.3 12.1 0.44 10.9 2.2 2.8 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Pkinase PF00069.25 ORX49096.1 - 1.6e-07 31.0 0.0 1.7e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49096.1 - 0.029 13.7 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Far-17a_AIG1 PF04750.14 ORX49097.1 - 3.3e-05 23.3 28.5 4.7e-05 22.8 28.5 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein bZIP_1 PF00170.21 ORX49098.1 - 0.00029 20.9 7.9 0.00048 20.2 7.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor IMD PF08397.11 ORX49098.1 - 0.0063 15.9 3.0 0.0092 15.4 3.0 1.4 1 1 0 1 1 1 1 IRSp53/MIM homology domain bZIP_2 PF07716.15 ORX49098.1 - 0.0069 16.5 8.5 0.0069 16.4 7.6 1.5 1 1 0 1 1 1 1 Basic region leucine zipper M PF02370.16 ORX49098.1 - 0.035 14.6 3.0 0.094 13.3 3.0 1.8 1 0 0 1 1 1 0 M protein repeat DUF2400 PF09674.10 ORX49098.1 - 0.13 12.3 1.7 0.15 12.0 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) DUF3395 PF11875.8 ORX49098.1 - 0.19 11.6 2.8 0.25 11.2 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3395) MCU PF04678.13 ORX49098.1 - 0.52 10.4 3.4 0.6 10.2 3.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter bZIP_Maf PF03131.17 ORX49098.1 - 0.97 10.0 11.7 1.4 9.5 11.7 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Ribosomal_L7Ae PF01248.26 ORX49099.1 - 3.1e-23 81.3 1.7 6.3e-23 80.3 1.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATPase_2 PF01637.18 ORX49099.1 - 0.022 14.7 2.0 0.039 13.9 2.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 ORX49099.1 - 0.046 12.9 0.6 0.29 10.3 0.1 2.0 2 0 0 2 2 2 0 KAP family P-loop domain RRM_1 PF00076.22 ORX49100.1 - 4.8e-19 67.9 0.1 6.5e-19 67.5 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX49100.1 - 0.0018 18.1 0.0 0.0036 17.1 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 ORX49100.1 - 0.039 13.6 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 ORX49101.1 - 1.2e-13 50.4 8.0 5.7e-07 29.2 1.1 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX49101.1 - 5.3e-11 42.2 17.3 1.6e-06 28.0 3.4 2.3 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH PF00642.24 ORX49101.1 - 6.2e-10 38.7 6.9 0.00022 21.0 1.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ORX49101.1 - 8.3e-08 32.9 6.4 0.0018 18.9 0.5 2.5 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 ORX49101.1 - 6.4e-06 26.3 1.0 1.3e-05 25.3 1.0 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 ORX49101.1 - 0.019 15.4 15.9 0.026 15.0 3.3 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Darcynin PF17074.5 ORX49102.1 - 0.026 14.8 0.0 0.043 14.0 0.0 1.3 1 0 0 1 1 1 0 Darcynin, domain of unknown function Synaptobrevin PF00957.21 ORX49104.1 - 4.2e-33 113.0 0.3 5.3e-33 112.7 0.3 1.1 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 ORX49104.1 - 3.4e-14 52.6 0.0 6.6e-14 51.7 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain MCU PF04678.13 ORX49104.1 - 0.0029 17.7 0.1 0.0033 17.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial calcium uniporter DUF2721 PF11026.8 ORX49104.1 - 0.18 11.7 0.2 0.3 11.0 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) DUF1308 PF07000.11 ORX49105.1 - 7.3e-25 87.8 0.0 8.6e-18 64.8 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1308) DUF5614 PF18474.1 ORX49105.1 - 1.1e-08 34.7 0.0 0.00036 19.9 0.0 2.3 2 0 0 2 2 2 2 Family of unknown function (DUF5614) zf-C2H2 PF00096.26 ORX49106.1 - 5e-09 36.1 13.8 0.0002 21.6 4.8 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX49106.1 - 1.2e-07 31.8 19.3 1.4e-05 25.3 4.5 3.5 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX49106.1 - 0.00025 21.6 11.1 0.062 14.2 1.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX49106.1 - 0.0032 18.1 0.2 0.007 17.0 0.2 1.5 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-C2H2_8 PF15909.5 ORX49106.1 - 0.026 14.8 1.1 0.026 14.8 1.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc ribbon TPK_catalytic PF04263.16 ORX49108.1 - 7.6e-35 119.6 0.1 2.3e-34 118.0 0.0 1.7 1 1 1 2 2 2 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ORX49108.1 - 1.2e-20 72.9 0.0 2.3e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Arf PF00025.21 ORX49110.1 - 2.4e-69 232.2 2.5 2.8e-69 232.0 2.5 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX49110.1 - 7.4e-16 58.4 1.5 1e-15 58.0 1.5 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX49110.1 - 4.1e-14 52.5 0.7 4.7e-14 52.3 0.7 1.0 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ORX49110.1 - 5.8e-14 51.9 0.7 7.6e-14 51.5 0.7 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ORX49110.1 - 7.6e-12 45.0 2.3 4.9e-09 35.8 0.8 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ORX49110.1 - 3.3e-09 36.8 0.4 5.5e-09 36.1 0.4 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX49110.1 - 8.2e-08 31.9 0.8 9.7e-08 31.6 0.8 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX49110.1 - 0.0074 15.8 1.7 0.92 9.0 1.7 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX49110.1 - 0.01 15.4 1.9 0.034 13.7 1.9 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_14 PF13173.6 ORX49110.1 - 0.015 15.3 0.3 0.031 14.3 0.3 1.6 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ORX49110.1 - 0.02 14.5 4.2 0.22 11.1 0.8 2.1 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_25 PF13481.6 ORX49110.1 - 0.039 13.5 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX49110.1 - 0.04 14.4 2.2 0.094 13.2 2.2 1.5 1 1 0 1 1 1 0 ABC transporter CotH PF08757.11 ORX49111.1 - 3.4e-42 145.1 0.0 5e-42 144.6 0.0 1.2 1 0 0 1 1 1 1 CotH kinase protein DUF1297 PF06973.12 ORX49111.1 - 0.16 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) Sugar_tr PF00083.24 ORX49112.1 - 2.5e-94 316.7 33.1 8.1e-94 315.0 33.1 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX49112.1 - 1.1e-30 106.7 38.1 6.7e-30 104.2 31.3 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 ORX49113.1 - 1.7e-75 253.8 0.0 2.1e-75 253.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49113.1 - 1.1e-39 136.2 0.0 1.5e-39 135.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49113.1 - 2e-08 33.9 0.0 4.1e-08 32.9 0.0 1.5 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX49113.1 - 0.00059 18.9 0.2 0.00085 18.4 0.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX49113.1 - 0.085 12.8 0.0 2.3 8.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Cys_Met_Meta_PP PF01053.20 ORX49114.1 - 1.7e-37 128.8 0.0 2.4e-37 128.4 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX49114.1 - 0.07 12.3 0.0 0.15 11.2 0.0 1.5 1 0 0 1 1 1 0 Aminotransferase class I and II Cpn60_TCP1 PF00118.24 ORX49115.1 - 1.4e-145 485.7 11.4 1.5e-145 485.6 11.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CRM1_repeat PF18777.1 ORX49115.1 - 0.087 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat DUF1741 PF08427.10 ORX49117.1 - 2.3e-52 178.0 3.1 2.3e-52 178.0 3.1 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1741) XPC-binding PF09280.11 ORX49117.1 - 1.5 8.6 5.5 0.5 10.1 0.1 3.1 3 0 0 3 3 3 0 XPC-binding domain SNF2_N PF00176.23 ORX49118.1 - 1.2e-27 96.5 0.3 2.8e-27 95.3 0.3 1.6 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX49118.1 - 6.9e-16 58.6 0.1 1.8e-15 57.3 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ORX49118.1 - 1.8e-06 27.4 0.1 2.9e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ORX49118.1 - 0.03 14.3 0.0 0.082 12.9 0.0 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF4499 PF14934.6 ORX49119.1 - 2.9e-11 43.5 8.0 1.2e-10 41.5 8.3 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4499) DUF2470 PF10615.9 ORX49119.1 - 1.2e-07 32.2 0.0 1.8e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Cation_efflux PF01545.21 ORX49120.1 - 9.9e-55 185.4 9.2 1.3e-54 185.0 9.2 1.1 1 0 0 1 1 1 1 Cation efflux family NicO PF03824.16 ORX49120.1 - 0.0015 17.9 2.3 0.0024 17.3 2.3 1.3 1 0 0 1 1 1 1 High-affinity nickel-transport protein DUF2776 PF10951.8 ORX49120.1 - 0.084 12.1 1.8 0.14 11.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2776) Arrestin_C PF02752.22 ORX49121.1 - 5.5e-16 59.2 0.0 9.2e-14 52.0 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX49121.1 - 5.2e-13 49.3 0.0 1.4e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain DUF3488 PF11992.8 ORX49123.1 - 0.0054 15.7 0.6 0.0088 15.0 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3488) WD40 PF00400.32 ORX49124.1 - 3.6e-15 56.1 3.8 0.0074 17.1 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX49124.1 - 2.6e-06 27.7 0.0 5.4e-05 23.4 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain R2K_3 PF14243.6 ORX49124.1 - 0.066 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Ge1_WD40 PF16529.5 ORX49124.1 - 0.089 11.7 0.2 1.2 8.0 0.0 2.5 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX49124.1 - 0.11 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Hira PF07569.11 ORX49124.1 - 0.19 11.5 0.0 0.5 10.0 0.0 1.7 1 0 0 1 1 1 0 TUP1-like enhancer of split GAS2 PF02187.17 ORX49124.1 - 0.19 11.9 0.0 0.52 10.4 0.0 1.8 1 1 1 2 2 2 0 Growth-Arrest-Specific Protein 2 Domain Brix PF04427.18 ORX49125.1 - 1.6e-44 152.3 0.1 2.2e-44 151.9 0.1 1.2 1 0 0 1 1 1 1 Brix domain MOSP_N PF02707.16 ORX49125.1 - 0.077 12.8 1.0 0.39 10.5 0.0 2.4 3 0 0 3 3 3 0 Major Outer Sheath Protein N-terminal region G0-G1_switch_2 PF15103.6 ORX49125.1 - 0.14 12.6 4.0 0.18 12.3 3.0 1.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 Gti1_Pac2 PF09729.9 ORX49126.1 - 1.8e-56 191.1 1.7 6.9e-43 146.8 0.1 2.6 2 1 1 3 3 3 2 Gti1/Pac2 family Cpn10 PF00166.21 ORX49127.1 - 5.4e-30 103.3 0.1 6.1e-30 103.1 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit HU-CCDC81_bac_1 PF18174.1 ORX49127.1 - 0.036 13.9 0.0 1.7 8.6 0.0 2.2 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 1 RFC1 PF08519.12 ORX49128.1 - 3.8e-38 131.1 0.0 1.5e-36 125.9 0.0 2.4 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 ORX49128.1 - 4.9e-13 49.6 0.0 1.5e-12 48.1 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 ORX49128.1 - 2.4e-12 47.1 0.0 4.8e-12 46.1 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Rad17 PF03215.15 ORX49128.1 - 6.6e-12 45.7 0.0 3.6e-11 43.3 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 ORX49128.1 - 2.4e-05 24.9 0.0 7.6e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ORX49128.1 - 4.6e-05 23.2 0.0 9.1e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX49128.1 - 7.3e-05 23.1 0.0 0.00022 21.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX49128.1 - 0.00043 20.3 0.0 0.00096 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX49128.1 - 0.00061 20.2 0.1 0.0022 18.4 0.0 1.8 1 1 1 2 2 2 1 AAA ATPase domain PTCB-BRCT PF12738.7 ORX49128.1 - 0.002 18.1 0.0 0.0047 16.8 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain AAA_33 PF13671.6 ORX49128.1 - 0.0029 17.8 0.0 0.0069 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ORX49128.1 - 0.0051 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX49128.1 - 0.0052 16.3 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX49128.1 - 0.0067 15.7 0.0 0.013 14.7 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin DNA_pol3_delta PF06144.13 ORX49128.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_17 PF13207.6 ORX49128.1 - 0.011 16.1 0.0 0.046 14.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ORX49128.1 - 0.027 14.4 0.1 0.071 13.0 0.1 1.7 1 1 1 2 2 2 0 NTPase NACHT PF05729.12 ORX49128.1 - 0.035 14.0 0.0 0.7 9.8 0.0 2.4 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ORX49128.1 - 0.039 13.7 0.0 0.077 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX49128.1 - 0.049 13.9 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX49128.1 - 0.062 13.7 0.1 0.51 10.7 0.0 2.7 3 1 0 3 3 2 0 RNA helicase TIP49 PF06068.13 ORX49128.1 - 0.093 11.9 0.0 0.19 10.9 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_30 PF13604.6 ORX49128.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ORX49128.1 - 0.11 12.6 0.0 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_assoc_2 PF16193.5 ORX49128.1 - 0.13 12.6 0.0 0.47 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA C-terminal domain Peptidase_M22 PF00814.25 ORX49129.1 - 2.6e-88 296.3 0.0 3.1e-88 296.0 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ORX49129.1 - 0.019 14.7 0.0 0.051 13.2 0.0 1.7 2 0 0 2 2 2 0 Carbamoyltransferase N-terminus BAR PF03114.18 ORX49130.1 - 1.3e-34 119.9 13.6 1.6e-34 119.6 13.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 ORX49130.1 - 6.8e-16 57.6 0.1 1.3e-15 56.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX49130.1 - 9.4e-16 57.4 0.2 1.6e-15 56.7 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX49130.1 - 9.8e-11 41.2 0.1 3.2e-10 39.5 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain DDRGK PF09756.9 ORX49130.1 - 2.4 7.7 13.0 0.18 11.4 8.3 1.4 2 0 0 2 2 2 0 DDRGK domain DUF3896 PF13035.6 ORX49130.1 - 5.5 7.2 9.0 17 5.7 9.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3896) V_ATPase_I PF01496.19 ORX49131.1 - 0 1081.1 3.1 0 1080.7 3.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SlyX PF04102.12 ORX49131.1 - 0.14 12.8 3.0 0.51 11.0 0.9 2.9 3 0 0 3 3 3 0 SlyX Lebercilin PF15619.6 ORX49131.1 - 0.67 9.6 5.4 0.17 11.5 2.2 1.6 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease PspB PF06667.12 ORX49131.1 - 2.3 8.3 5.3 1.3 9.1 0.1 3.1 4 0 0 4 4 4 0 Phage shock protein B Abhydrolase_6 PF12697.7 ORX49132.1 - 2.8e-09 37.9 0.0 3.5e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX49132.1 - 2.9e-09 36.6 0.0 3.7e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX49132.1 - 6.4e-05 22.7 0.0 0.00032 20.4 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Tau95 PF09734.9 ORX49133.1 - 1.1e-34 120.2 1.8 2e-34 119.4 1.8 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 ORX49133.1 - 2.5e-28 98.8 0.0 7.5e-28 97.3 0.0 1.9 1 0 0 1 1 1 1 Tau95 Triple barrel domain TFIIF_beta PF02270.15 ORX49133.1 - 0.058 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 TFIIF, beta subunit HTH domain GCD14 PF08704.10 ORX49135.1 - 1.1e-21 77.7 0.0 1.4e-21 77.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_24 PF13578.6 ORX49135.1 - 4e-05 24.6 0.0 6.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX49135.1 - 9.1e-05 22.3 0.0 0.00015 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX49135.1 - 0.00012 21.9 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ORX49135.1 - 0.00039 21.1 0.0 0.00068 20.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX49135.1 - 0.022 14.2 0.0 0.036 13.6 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase MTS PF05175.14 ORX49135.1 - 0.066 12.8 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain RrnaAD PF00398.20 ORX49135.1 - 0.099 11.7 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_3 PF01596.17 ORX49135.1 - 0.18 10.9 0.0 0.25 10.5 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase LCM PF04072.14 ORX49136.1 - 2.2e-25 89.7 0.0 9.6e-25 87.6 0.0 1.8 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase OrgA_MxiK PF09482.10 ORX49136.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Bacterial type III secretion apparatus protein (OrgA_MxiK) CRM1_C PF08767.11 ORX49137.1 - 8.2e-57 192.8 0.0 2.6e-56 191.2 0.0 1.8 2 0 0 2 2 2 1 CRM1 C terminal Xpo1 PF08389.12 ORX49137.1 - 4.3e-18 65.8 10.0 1.4e-17 64.2 0.5 4.8 5 0 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 ORX49137.1 - 7.6e-08 32.2 0.7 4.1e-07 29.8 0.0 2.7 3 0 0 3 3 3 1 Importin-beta N-terminal domain CRM1_repeat PF18777.1 ORX49137.1 - 0.0011 18.5 0.5 0.0011 18.5 0.5 2.4 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat HEAT PF02985.22 ORX49137.1 - 0.0026 17.9 0.7 0.021 15.1 0.1 3.0 2 0 0 2 2 2 1 HEAT repeat DUF3454 PF11936.8 ORX49138.1 - 0.035 14.5 0.2 0.037 14.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3454) tRNA_int_end_N2 PF12928.7 ORX49140.1 - 3.5e-08 33.5 0.0 8.2e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 ORX49140.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain RPN13_C PF16550.5 ORX49141.1 - 3e-29 101.4 4.7 3e-29 101.4 4.7 1.8 2 0 0 2 2 2 1 UCH-binding domain Proteasom_Rpn13 PF04683.13 ORX49141.1 - 4.1e-29 101.0 0.1 8.2e-29 100.0 0.1 1.5 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor Pex14_N PF04695.13 ORX49141.1 - 0.34 11.6 8.5 0.73 10.5 8.5 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EOS1 PF12326.8 ORX49142.1 - 2e-09 37.6 18.1 6e-09 36.1 18.0 1.8 1 1 0 1 1 1 1 N-glycosylation protein Galactosyl_T PF01762.21 ORX49142.1 - 1.3e-08 34.9 0.0 2.3e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Galactosyltransferase Gly_transf_sug PF04488.15 ORX49142.1 - 8.6e-08 32.7 1.1 1.5e-07 31.9 0.1 2.0 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif Gb3_synth PF04572.12 ORX49142.1 - 1.1e-07 32.1 0.0 2.5e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Alpha 1,4-glycosyltransferase conserved region Caps_synth PF05704.12 ORX49142.1 - 0.0027 17.1 0.3 0.0063 15.9 0.3 1.5 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein FAM124 PF15067.6 ORX49142.1 - 0.014 15.1 0.1 0.031 13.9 0.1 1.5 1 0 0 1 1 1 0 FAM124 family TcdA_TcdB PF12919.7 ORX49142.1 - 0.084 12.2 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain PEPCK_N PF17297.2 ORX49142.1 - 0.12 12.0 0.1 0.22 11.1 0.1 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain WD40 PF00400.32 ORX49143.1 - 7.4e-40 134.2 16.1 1.2e-07 32.2 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX49143.1 - 2.6e-19 69.3 5.8 0.0026 18.0 0.3 6.2 1 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX49143.1 - 1.1e-08 35.1 3.8 0.0016 18.3 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 ORX49143.1 - 0.00012 21.3 0.0 0.21 10.6 0.0 2.1 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 ORX49143.1 - 0.12 11.4 0.2 4.9 6.0 0.0 2.8 2 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pkinase PF00069.25 ORX49144.1 - 2.8e-57 194.1 0.0 3.4e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49144.1 - 4.5e-40 137.6 0.0 5.9e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX49144.1 - 1.4e-07 30.6 0.0 2e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX49144.1 - 2.9e-07 30.1 0.0 3.6e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX49144.1 - 0.019 14.9 0.0 0.55 10.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX49144.1 - 0.029 13.3 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ORX49144.1 - 0.054 12.8 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX49144.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 GTP_EFTU PF00009.27 ORX49145.1 - 2.1e-61 206.9 0.1 3.3e-61 206.2 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX49145.1 - 1.2e-39 134.9 0.1 3e-39 133.5 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ORX49145.1 - 1.1e-30 105.6 0.0 2.6e-30 104.3 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ORX49145.1 - 3.3e-25 87.9 0.1 7.4e-25 86.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX49145.1 - 4.7e-12 46.1 0.3 1.1e-11 45.0 0.3 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ORX49145.1 - 3.2e-06 27.0 0.5 6.3e-06 26.0 0.0 1.7 2 0 0 2 2 2 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ORX49145.1 - 0.0032 17.5 0.0 0.0076 16.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 ORX49145.1 - 0.028 13.7 0.0 0.092 12.1 0.0 1.8 1 0 0 1 1 1 0 AIG1 family Ribosomal_L27A PF00828.19 ORX49146.1 - 1.1e-38 132.8 0.2 1.8e-38 132.1 0.2 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Slx4 PF09494.10 ORX49146.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Slx4 endonuclease SHMT PF00464.19 ORX49147.1 - 3.1e-202 671.5 0.0 3.6e-202 671.3 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 ORX49147.1 - 0.095 12.0 0.1 0.2 10.9 0.0 1.5 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Fungal_trans PF04082.18 ORX49148.1 - 3.1e-20 72.3 0.1 4.9e-20 71.7 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX49148.1 - 5.8e-09 35.9 12.6 5.8e-09 35.9 12.6 2.3 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX49149.1 - 2.2e-16 59.7 5.4 2e-15 56.5 5.4 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX49149.1 - 2.3e-07 30.8 11.1 5.8e-07 29.5 11.1 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Ad_cyc_g-alpha PF08509.11 ORX49149.1 - 0.00082 19.0 0.2 0.7 9.7 0.0 3.2 2 0 0 2 2 2 2 Adenylate cyclase G-alpha binding domain Peptidase_C14 PF00656.22 ORX49150.1 - 5.1e-59 200.2 0.5 7.1e-59 199.8 0.5 1.1 1 0 0 1 1 1 1 Caspase domain DUF4203 PF13886.6 ORX49151.1 - 6.2e-30 104.4 39.8 6.2e-30 104.4 39.8 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4203) CUE PF02845.16 ORX49152.1 - 1e-09 37.9 0.1 2.5e-09 36.7 0.1 1.6 1 0 0 1 1 1 1 CUE domain Zn_clus PF00172.18 ORX49153.1 - 4.5e-06 26.7 11.3 9.6e-06 25.6 11.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 ORX49154.1 - 5.7e-10 39.2 13.6 1.4e-09 37.9 13.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX49154.1 - 1.7e-05 24.0 0.1 2.9e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain RNase_PH PF01138.21 ORX49155.1 - 3.5e-23 82.6 0.1 7.7e-23 81.4 0.0 1.6 2 0 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX49155.1 - 4.3e-06 26.7 0.0 1.7e-05 24.8 0.0 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 LRR_8 PF13855.6 ORX49156.1 - 3.2e-40 135.7 44.5 1.7e-11 43.7 5.8 9.4 5 4 5 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 ORX49156.1 - 4.2e-38 128.7 53.2 1.8e-06 28.2 0.7 11.6 7 3 5 13 13 13 11 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX49156.1 - 2.5e-08 33.6 28.4 0.00067 19.2 1.8 5.9 2 2 3 6 6 6 5 Leucine-rich repeat LRR_1 PF00560.33 ORX49156.1 - 5.4e-08 32.3 41.1 0.64 10.8 0.1 14.1 15 1 0 15 15 15 4 Leucine Rich Repeat LRR_5 PF13306.6 ORX49156.1 - 0.0013 18.7 0.0 0.04 13.9 0.0 2.9 2 1 1 3 3 3 1 BspA type Leucine rich repeat region (6 copies) LRR_6 PF13516.6 ORX49156.1 - 0.0032 17.4 41.1 1.5 9.1 0.2 11.5 12 0 0 12 12 12 3 Leucine Rich repeat Kelch_4 PF13418.6 ORX49156.1 - 0.29 11.2 0.7 4.8 7.3 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain LRR_2 PF07723.13 ORX49156.1 - 2.7 8.8 6.6 19 6.1 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat BatA PF07584.11 ORX49157.1 - 0.14 12.5 2.5 0.53 10.7 2.5 2.0 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal zf-H2C2_2 PF13465.6 ORX49158.1 - 4.4e-10 39.5 26.6 7.4e-05 23.0 2.5 4.0 3 1 1 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX49158.1 - 4.7e-09 36.2 27.9 0.00012 22.3 0.3 4.0 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX49158.1 - 9.6e-07 29.1 23.2 0.021 15.6 0.3 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX49158.1 - 1.1e-05 25.3 20.4 6.3e-05 22.9 0.1 3.8 3 1 0 3 3 3 2 C2H2-type zinc finger zf-met PF12874.7 ORX49158.1 - 4.5e-05 23.7 10.4 0.0079 16.6 0.1 3.5 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX49158.1 - 0.0027 17.9 17.8 0.2 12.0 1.1 3.4 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 ORX49158.1 - 0.37 10.7 10.8 0.15 12.0 2.8 2.9 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain C1_4 PF07975.12 ORX49158.1 - 2.2 8.6 10.5 5.7 7.3 6.1 2.4 1 1 2 3 3 3 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 ORX49158.1 - 2.7 8.0 9.0 17 5.5 0.7 3.1 1 1 2 3 3 3 0 zinc-ribbons DUF2225 PF09986.9 ORX49158.1 - 4.6 6.9 11.1 3.6 7.2 5.6 2.6 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Zn-ribbon_8 PF09723.10 ORX49158.1 - 6.4 7.0 11.8 4.4 7.5 2.2 3.1 2 1 2 4 4 4 0 Zinc ribbon domain zf_UBZ PF18439.1 ORX49158.1 - 6.7 6.4 9.8 24 4.6 2.1 3.4 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Pkinase PF00069.25 ORX49159.1 - 2.2e-71 240.4 0.1 3.2e-71 239.8 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49159.1 - 5.7e-52 176.6 0.1 9.1e-52 175.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX49159.1 - 4.8e-19 68.5 0.0 1e-18 67.4 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 ORX49159.1 - 9.5e-10 38.9 0.3 1.8e-09 38.0 0.3 1.5 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 ORX49159.1 - 4e-07 29.1 0.0 4e-07 29.1 0.0 2.2 3 1 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 ORX49159.1 - 2.2e-05 23.9 0.3 0.0001 21.7 0.4 1.9 1 1 1 2 2 2 1 Kinase-like PH_9 PF15410.6 ORX49159.1 - 0.0018 18.6 0.2 0.14 12.5 0.2 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Haspin_kinase PF12330.8 ORX49159.1 - 0.0085 15.1 3.0 0.033 13.1 3.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain PH_2 PF08458.10 ORX49159.1 - 0.0091 16.3 0.1 0.061 13.7 0.0 2.1 2 0 0 2 2 2 1 Plant pleckstrin homology-like region APH PF01636.23 ORX49159.1 - 0.048 13.6 0.0 0.66 9.9 0.1 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX49159.1 - 0.17 11.2 0.4 0.35 10.2 0.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH_11 PF15413.6 ORX49159.1 - 0.22 12.0 0.8 7.1 7.1 0.8 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain STE PF02200.16 ORX49160.1 - 3.2e-54 182.0 0.0 5.6e-54 181.2 0.0 1.4 1 0 0 1 1 1 1 STE like transcription factor Amino_oxidase PF01593.24 ORX49161.1 - 3e-68 231.2 0.0 1.2e-66 225.8 0.0 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX49161.1 - 1.2e-09 38.2 0.1 3e-09 37.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX49161.1 - 1.8e-06 27.4 0.4 0.00055 19.3 0.2 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX49161.1 - 3.4e-06 26.9 0.2 2.2e-05 24.2 0.2 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX49161.1 - 1.5e-05 24.4 0.0 0.017 14.4 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DUF3237 PF11578.8 ORX49161.1 - 0.00088 19.1 0.0 0.52 10.2 0.0 2.6 2 1 0 3 3 3 2 Protein of unknown function (DUF3237) NAD_binding_9 PF13454.6 ORX49161.1 - 0.0013 18.8 0.3 0.94 9.5 0.1 2.4 2 0 0 2 2 2 2 FAD-NAD(P)-binding Thi4 PF01946.17 ORX49161.1 - 0.002 17.4 0.1 0.0032 16.7 0.1 1.2 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ORX49161.1 - 0.0043 16.2 0.4 0.0068 15.5 0.4 1.3 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ORX49161.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX49161.1 - 0.014 14.1 0.3 0.027 13.2 0.3 1.5 1 0 0 1 1 1 0 HI0933-like protein Glyco_hydro_59 PF02057.15 ORX49161.1 - 0.037 13.3 0.2 0.11 11.7 0.2 1.8 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 Pyr_redox PF00070.27 ORX49161.1 - 0.11 13.1 0.1 3.6 8.2 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADH_N PF08240.12 ORX49162.1 - 1.9e-25 88.9 2.5 1.9e-25 88.9 2.5 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX49162.1 - 6.1e-20 71.5 0.0 9.5e-20 70.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX49162.1 - 0.00014 22.9 0.0 0.00021 22.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX49162.1 - 0.00031 20.2 0.0 0.00048 19.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX49162.1 - 0.0065 15.8 0.0 0.0094 15.3 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Oxidored_nitro PF00148.19 ORX49162.1 - 0.016 13.9 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase ELFV_dehydrog PF00208.21 ORX49162.1 - 0.056 13.2 0.0 0.08 12.6 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ADH_N PF08240.12 ORX49163.1 - 5e-25 87.5 3.9 8.7e-25 86.7 3.9 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX49163.1 - 2.8e-17 62.9 0.0 4.3e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX49163.1 - 8.5e-06 26.8 0.0 1.2e-05 26.3 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX49163.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 ORX49163.1 - 0.041 13.6 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AlaDh_PNT_C PF01262.21 ORX49163.1 - 0.069 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HECT_2 PF09814.9 ORX49164.1 - 2.9e-47 161.3 0.3 3.6e-47 161.0 0.3 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zf-BED PF02892.15 ORX49164.1 - 0.042 13.9 5.1 3.8 7.6 0.1 3.3 3 0 0 3 3 3 0 BED zinc finger zf-ribbon_3 PF13248.6 ORX49164.1 - 0.59 9.6 6.9 6.3 6.4 0.5 3.2 3 0 0 3 3 3 0 zinc-ribbon domain Pyridoxal_deC PF00282.19 ORX49165.1 - 1.1e-18 67.1 0.0 1.8e-18 66.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Ribosomal_L21p PF00829.21 ORX49165.1 - 4.9e-11 42.8 0.1 1.2e-10 41.5 0.1 1.7 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Aminotran_5 PF00266.19 ORX49165.1 - 7.5e-09 35.0 0.0 1.8e-08 33.7 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ORX49165.1 - 2.2e-05 24.0 0.2 3.6e-05 23.2 0.2 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family TcpS PF17456.2 ORX49165.1 - 0.041 13.9 0.2 0.077 13.0 0.2 1.4 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S Paramyx_P_V_C PF03210.13 ORX49165.1 - 0.047 13.5 0.2 1.3 8.8 0.1 2.3 2 0 0 2 2 2 0 Paramyxovirus P/V phosphoprotein C-terminal Zn_clus PF00172.18 ORX49166.1 - 0.00033 20.7 8.0 0.00063 19.8 8.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SWIRM-assoc_1 PF16495.5 ORX49166.1 - 0.2 11.6 3.4 2.2 8.3 0.4 2.5 2 0 0 2 2 2 0 SWIRM-associated region 1 SRF-TF PF00319.18 ORX49167.1 - 5.9e-21 73.7 0.1 8.4e-21 73.2 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) HbrB PF08539.11 ORX49168.1 - 4.8e-36 124.3 3.9 7.6e-35 120.4 1.0 2.9 2 1 0 2 2 2 1 HbrB-like Cullin PF00888.22 ORX49168.1 - 0.023 13.3 0.0 0.031 12.9 0.0 1.2 1 0 0 1 1 1 0 Cullin family DUF1394 PF07159.12 ORX49170.1 - 0.033 13.4 0.1 0.042 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1394) Asp PF00026.23 ORX49171.1 - 4.6e-93 312.1 11.6 5.5e-93 311.8 11.6 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX49171.1 - 7.8e-16 58.8 12.4 1.1e-10 42.0 0.6 3.3 3 1 1 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX49171.1 - 1e-05 26.1 3.3 0.054 14.1 0.3 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 ORX49171.1 - 0.0014 18.4 0.0 0.0076 16.0 0.0 2.2 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX49171.1 - 0.023 15.2 0.4 13 6.4 0.1 3.1 2 2 0 2 2 2 0 gag-polyprotein putative aspartyl protease AAA PF00004.29 ORX49172.1 - 1.1e-43 148.8 0.0 2.7e-43 147.6 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX49172.1 - 8.8e-12 44.6 0.1 1.8e-11 43.6 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ORX49172.1 - 1.4e-10 40.9 0.6 2.8e-10 40.0 0.0 1.9 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ORX49172.1 - 6.4e-07 29.4 0.2 1.7e-05 24.9 0.1 2.8 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX49172.1 - 6.7e-07 29.6 0.0 1.8e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX49172.1 - 2.9e-06 27.1 0.0 5.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX49172.1 - 3.4e-06 27.6 0.1 0.0015 19.0 0.2 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX49172.1 - 0.00014 22.2 0.1 0.0052 17.1 0.1 2.4 1 1 1 2 2 2 1 AAA domain Prot_ATP_OB_N PF17758.1 ORX49172.1 - 0.00026 20.6 0.1 0.00096 18.8 0.0 1.9 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain DUF815 PF05673.13 ORX49172.1 - 0.00035 19.8 0.0 0.0011 18.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ORX49172.1 - 0.00038 20.0 0.0 0.00072 19.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 ORX49172.1 - 0.0017 17.7 0.0 0.0042 16.5 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ORX49172.1 - 0.0023 17.9 0.0 0.0041 17.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ORX49172.1 - 0.0025 18.3 0.0 0.0076 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain TIP49 PF06068.13 ORX49172.1 - 0.0031 16.8 0.0 0.006 15.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 ORX49172.1 - 0.0032 17.2 0.0 0.0061 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX49172.1 - 0.0042 17.1 0.0 0.0094 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX49172.1 - 0.0056 16.4 0.1 0.019 14.7 0.0 1.8 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_33 PF13671.6 ORX49172.1 - 0.0062 16.7 0.0 0.016 15.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 ORX49172.1 - 0.0072 16.7 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_3 PF07726.11 ORX49172.1 - 0.013 15.4 0.0 0.026 14.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX49172.1 - 0.016 14.9 0.1 0.061 13.0 0.0 1.9 1 1 1 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 ORX49172.1 - 0.046 13.6 0.2 0.11 12.3 0.1 1.7 2 0 0 2 2 2 0 NACHT domain Parvo_NS1 PF01057.17 ORX49172.1 - 0.06 12.4 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 ATPase PF06745.13 ORX49172.1 - 0.069 12.5 0.7 0.3 10.4 0.0 2.3 2 1 1 3 3 3 0 KaiC MRP-S35 PF10246.9 ORX49172.1 - 0.071 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 PhoH PF02562.16 ORX49172.1 - 0.075 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_28 PF13521.6 ORX49172.1 - 0.082 13.1 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ORX49172.1 - 0.11 12.2 0.4 0.34 10.6 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase AAA_30 PF13604.6 ORX49172.1 - 0.14 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX49172.1 - 0.17 11.4 0.1 0.39 10.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ORX49172.1 - 0.18 11.6 0.2 0.39 10.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain RNA_pol_Rpb5_C PF01191.19 ORX49173.1 - 1.6e-34 117.6 0.2 3.1e-34 116.6 0.2 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 ORX49173.1 - 1.3e-20 73.7 0.0 2.2e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 ORX49173.1 - 0.0056 16.7 0.0 0.017 15.1 0.0 1.8 2 0 0 2 2 2 1 Restriction endonuclease RAG2 PF03089.14 ORX49177.1 - 0.0096 14.9 0.1 0.014 14.4 0.1 1.1 1 0 0 1 1 1 1 Recombination activating protein 2 N6-adenineMlase PF10237.9 ORX49177.1 - 0.041 13.7 0.1 0.075 12.8 0.1 1.4 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Ribosomal_L39 PF00832.20 ORX49178.1 - 9.1e-20 70.0 11.7 1.1e-19 69.8 11.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein Exo_endo_phos PF03372.23 ORX49179.1 - 4.2e-10 39.5 0.0 8.7e-10 38.5 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rgp1 PF08737.10 ORX49180.1 - 6e-97 325.4 0.1 2e-94 317.2 0.1 2.6 1 1 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 ORX49180.1 - 1e-06 29.3 0.2 0.094 13.2 0.2 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain CD52 PF15116.6 ORX49180.1 - 0.0074 16.3 1.4 0.043 13.8 1.4 2.4 1 0 0 1 1 1 1 CAMPATH-1 antigen DUF11 PF01345.18 ORX49180.1 - 0.12 12.7 0.7 1.7 9.0 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function DUF11 Abhydro_lipase PF04083.16 ORX49181.1 - 6.1e-16 57.7 0.0 1.6e-15 56.4 0.0 1.7 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ORX49181.1 - 4.4e-11 42.9 0.2 4.4e-10 39.6 0.1 2.2 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX49181.1 - 3.5e-07 29.8 0.7 5.6e-05 22.5 0.4 2.4 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX49181.1 - 9.5e-05 23.1 1.6 0.00019 22.1 1.6 1.6 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF1749 PF08538.10 ORX49181.1 - 0.056 12.5 0.0 0.11 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) DUF900 PF05990.12 ORX49181.1 - 0.11 12.0 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) PPI_Ypi1 PF07491.11 ORX49182.1 - 2.6e-24 84.8 6.6 2.6e-24 84.8 6.6 2.3 2 1 0 2 2 2 1 Protein phosphatase inhibitor IMUP PF15761.5 ORX49182.1 - 0.00062 20.4 11.4 0.00062 20.4 11.4 1.7 2 0 0 2 2 2 1 Immortalisation up-regulated protein CDC45 PF02724.14 ORX49182.1 - 0.066 11.5 3.5 0.078 11.3 3.5 1.0 1 0 0 1 1 1 0 CDC45-like protein CCDC106 PF15794.5 ORX49182.1 - 0.45 10.2 8.3 0.68 9.6 8.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Apc15p PF05841.11 ORX49182.1 - 0.88 10.4 5.9 1.9 9.3 4.1 2.0 2 0 0 2 2 2 0 Apc15p protein Ycf1 PF05758.12 ORX49182.1 - 0.91 7.3 2.0 1.1 7.0 2.0 1.0 1 0 0 1 1 1 0 Ycf1 FancD2 PF14631.6 ORX49182.1 - 3 5.1 4.2 3.7 4.8 4.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PHD PF00628.29 ORX49183.1 - 4.1e-10 39.4 9.1 4.1e-10 39.4 9.1 1.7 2 0 0 2 2 2 1 PHD-finger PHD_2 PF13831.6 ORX49183.1 - 0.00043 19.8 3.1 0.00085 18.8 3.1 1.5 1 0 0 1 1 1 1 PHD-finger Di19_C PF14571.6 ORX49183.1 - 1 9.9 5.0 7.2 7.2 5.0 2.5 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal C1_1 PF00130.22 ORX49183.1 - 1.1 9.1 9.1 0.098 12.6 3.1 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Pet100 PF09803.9 ORX49184.1 - 1.2e-23 83.4 0.8 1.6e-23 83.0 0.8 1.2 1 0 0 1 1 1 1 Pet100 SART-1 PF03343.13 ORX49185.1 - 1.3e-139 466.7 59.3 1.6e-139 466.4 59.3 1.0 1 0 0 1 1 1 1 SART-1 family PUD1_2 PF18457.1 ORX49185.1 - 0.11 12.5 3.1 0.51 10.3 0.5 2.6 2 1 0 2 2 2 0 Up-Regulated in long-lived daf-2 UIM PF02809.20 ORX49185.1 - 0.12 12.3 6.6 0.066 13.2 1.0 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif DarT PF14487.6 ORX49186.1 - 0.044 13.6 0.1 0.84 9.4 0.0 2.0 1 1 1 2 2 2 0 ssDNA thymidine ADP-ribosyltransferase, DarT Ribosomal_S6 PF01250.17 ORX49187.1 - 1.2e-25 89.5 0.0 1.4e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 PROCN PF08083.11 ORX49188.1 - 1.3e-235 781.6 9.3 2.8e-235 780.5 8.6 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ORX49188.1 - 8.6e-129 428.0 0.3 1.5e-128 427.2 0.3 1.4 1 0 0 1 1 1 1 PRP8 domain IV core PRO8NT PF08082.11 ORX49188.1 - 3.4e-89 296.6 4.8 8e-89 295.3 4.8 1.7 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U6-snRNA_bdg PF10596.9 ORX49188.1 - 2.7e-85 284.2 2.3 6.8e-85 282.9 2.3 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 ORX49188.1 - 6.3e-71 236.7 0.0 1.3e-70 235.7 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 ORX49188.1 - 8.7e-50 167.8 0.1 2e-49 166.6 0.1 1.7 1 0 0 1 1 1 1 PROCT (NUC072) domain RRM_4 PF10598.9 ORX49188.1 - 2e-46 156.2 0.4 5.7e-46 154.8 0.4 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 ORX49188.1 - 1.3e-07 31.6 0.0 3.3e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RTP1_C1 PF10363.9 ORX49189.1 - 3.1e-32 111.1 0.1 1.2e-31 109.2 0.1 2.1 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 ORX49189.1 - 1.8e-08 33.9 2.9 4.8e-08 32.5 2.9 1.8 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 HEAT_2 PF13646.6 ORX49189.1 - 0.0018 18.6 1.5 0.2 12.0 0.1 3.1 2 1 0 2 2 2 1 HEAT repeats MMS19_N PF14500.6 ORX49189.1 - 0.011 15.3 0.2 0.04 13.5 0.0 2.0 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II NIF PF03031.18 ORX49190.1 - 2.6e-47 160.5 0.3 3e-47 160.3 0.3 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase GDH_N PF12466.8 ORX49190.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.5 1 0 0 1 1 1 0 Glutamate dehydrogenase N terminal HAD PF12710.7 ORX49190.1 - 0.14 12.5 0.0 0.36 11.2 0.0 1.7 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Hormone_4 PF00220.17 ORX49190.1 - 0.31 11.1 0.9 0.65 10.1 0.9 1.6 1 0 0 1 1 1 0 Neurohypophysial hormones, N-terminal Domain NT-C2 PF10358.9 ORX49191.1 - 3.4e-27 95.0 0.8 4.2e-27 94.7 0.8 1.1 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Metallophos PF00149.28 ORX49192.1 - 4.2e-12 47.0 0.6 5.3e-12 46.7 0.6 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 ORX49192.1 - 0.00049 18.5 0.0 0.0016 16.9 0.0 1.7 2 0 0 2 2 2 1 Firmicute fructose-1,6-bisphosphatase AMP-binding PF00501.28 ORX49194.1 - 2.5e-44 151.5 0.0 3.5e-44 151.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 ORX49194.1 - 2e-10 40.4 0.5 4.7e-10 39.2 0.5 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 ORX49194.1 - 0.0085 17.1 0.1 0.02 15.9 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain NADH_dh_m_C1 PF15088.6 ORX49194.1 - 2.5 7.8 4.4 6.3 6.5 4.4 1.6 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Abhydrolase_1 PF00561.20 ORX49195.1 - 7.8e-20 71.6 0.1 2.1e-12 47.2 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX49195.1 - 1.9e-16 61.4 0.1 2.3e-16 61.1 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX49195.1 - 3.6e-14 52.6 0.0 2.9e-13 49.6 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 ORX49195.1 - 0.0002 21.2 0.0 0.052 13.3 0.0 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 ORX49195.1 - 0.00079 19.5 0.0 0.0035 17.4 0.0 1.9 2 0 0 2 2 2 1 TAP-like protein Peptidase_S15 PF02129.18 ORX49195.1 - 0.0011 18.6 0.0 0.0052 16.4 0.0 1.9 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ORX49195.1 - 0.0016 18.0 1.1 0.013 15.0 0.1 2.3 2 1 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 ORX49195.1 - 0.0019 17.9 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 ORX49195.1 - 0.0023 17.5 0.0 0.029 13.9 0.0 2.1 2 0 0 2 2 2 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 ORX49195.1 - 0.0025 17.7 0.0 0.0057 16.5 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIP PF03583.14 ORX49195.1 - 0.085 12.2 0.0 0.61 9.3 0.0 1.9 2 0 0 2 2 2 0 Secretory lipase PGAP1 PF07819.13 ORX49195.1 - 0.13 11.9 0.0 3.2 7.4 0.0 2.2 2 0 0 2 2 2 0 PGAP1-like protein Nterm_IS4 PF13006.7 ORX49195.1 - 0.14 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Insertion element 4 transposase N-terminal PPR_2 PF13041.6 ORX49196.1 - 0.0089 16.2 0.6 0.079 13.2 0.0 3.0 4 1 0 4 4 4 1 PPR repeat family ATP-cone PF03477.16 ORX49196.1 - 0.012 16.2 0.3 0.29 11.7 0.0 2.4 2 0 0 2 2 2 0 ATP cone domain DUF4618 PF15397.6 ORX49196.1 - 0.074 12.5 0.6 0.18 11.2 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) bZIP_1 PF00170.21 ORX49197.1 - 5.7e-09 35.9 11.8 5.5e-08 32.8 11.8 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX49197.1 - 0.00019 21.4 13.7 0.0035 17.4 9.4 2.4 1 1 1 2 2 2 2 Basic region leucine zipper KIAA1430 PF13879.6 ORX49197.1 - 0.045 14.5 9.2 0.34 11.7 0.2 2.9 2 2 1 3 3 3 0 KIAA1430 homologue CCD48 PF15799.5 ORX49197.1 - 0.063 11.6 1.6 0.086 11.1 1.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 bZIP_Maf PF03131.17 ORX49197.1 - 0.17 12.4 7.5 0.39 11.3 7.5 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Cep57_CLD_2 PF14197.6 ORX49197.1 - 0.38 10.9 7.7 0.69 10.0 7.7 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 CBS PF00571.28 ORX49198.1 - 2.5e-26 91.9 0.1 1.2e-06 28.8 0.1 4.9 4 1 0 4 4 4 4 CBS domain OAD_gamma PF04277.13 ORX49200.1 - 0.13 12.9 0.1 0.15 12.7 0.1 1.1 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain zf-C2H2 PF00096.26 ORX49201.1 - 2.2e-07 30.9 10.8 0.00051 20.4 2.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ORX49201.1 - 4.5e-05 23.7 3.0 0.12 12.7 0.3 2.6 2 0 0 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX49201.1 - 0.001 19.6 0.9 1.1 9.9 0.0 2.4 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX49201.1 - 0.0071 17.1 8.1 0.74 10.8 0.6 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX49201.1 - 0.012 16.0 1.0 0.012 16.0 1.0 4.0 4 0 0 4 4 4 0 Zinc-finger double domain zf-met PF12874.7 ORX49201.1 - 0.16 12.4 4.6 5.1 7.6 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf_C2H2_ZHX PF18387.1 ORX49201.1 - 0.28 10.9 2.1 0.83 9.3 2.1 1.7 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_6 PF13912.6 ORX49201.1 - 3.8 7.6 7.7 1.1 9.3 0.2 2.9 2 1 0 2 2 2 0 C2H2-type zinc finger tRNA-synt_2c PF01411.19 ORX49202.1 - 7.1e-156 519.9 0.0 8.2e-149 496.6 0.0 2.1 1 1 1 2 2 2 2 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ORX49202.1 - 2.4e-12 46.7 0.1 4.6e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ORX49202.1 - 0.00059 20.3 0.2 0.002 18.6 0.1 2.0 2 0 0 2 2 2 1 DHHA1 domain LdpA_C PF12617.8 ORX49202.1 - 0.027 14.1 0.1 0.054 13.1 0.1 1.4 1 0 0 1 1 1 0 Iron-Sulfur binding protein C terminal BAR PF03114.18 ORX49202.1 - 0.063 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 BAR domain FadA PF09403.10 ORX49202.1 - 0.073 13.6 0.1 0.36 11.3 0.0 2.1 1 1 1 2 2 2 0 Adhesion protein FadA DnaB_2 PF07261.11 ORX49202.1 - 0.11 12.3 0.0 0.54 10.0 0.0 2.2 2 0 0 2 2 2 0 Replication initiation and membrane attachment HALZ PF02183.18 ORX49202.1 - 0.26 11.5 2.7 0.52 10.6 2.7 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper PH PF00169.29 ORX49203.1 - 0.00087 19.8 0.2 0.0026 18.2 0.0 2.0 2 0 0 2 2 2 1 PH domain Sugar_tr PF00083.24 ORX49204.1 - 2.5e-81 273.9 24.5 2.5e-81 273.9 24.5 1.4 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX49204.1 - 1.2e-24 86.9 27.9 1.2e-24 86.9 27.9 3.0 1 1 2 3 3 3 1 Major Facilitator Superfamily Ac76 PF05814.11 ORX49204.1 - 0.00034 20.5 0.5 0.14 12.2 0.0 3.6 3 0 0 3 3 3 1 Orf76 (Ac76) BT1 PF03092.16 ORX49204.1 - 0.00069 18.0 0.6 0.00069 18.0 0.6 2.4 2 0 0 2 2 2 1 BT1 family DUF2976 PF11190.8 ORX49204.1 - 0.081 12.7 2.9 1.3 8.8 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) EMP24_GP25L PF01105.24 ORX49384.1 - 6.1e-44 150.1 0.2 6.8e-44 150.0 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Peptidase_M28 PF04389.17 ORX49385.1 - 1e-35 123.2 0.1 1.7e-35 122.5 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX49385.1 - 0.0034 17.1 0.0 0.0052 16.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 EamA PF00892.20 ORX49386.1 - 3e-06 27.4 23.1 4.6e-06 26.8 8.0 2.3 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 ORX49386.1 - 0.00021 20.8 4.3 0.00021 20.8 4.3 2.0 1 1 0 2 2 2 1 Triose-phosphate Transporter family PHO4 PF01384.20 ORX49386.1 - 2.4 7.1 15.4 0.19 10.7 5.4 2.3 1 1 0 2 2 2 0 Phosphate transporter family Acyltransferase PF01553.21 ORX49387.1 - 0.00036 20.2 0.0 0.0014 18.2 0.0 2.0 1 1 0 1 1 1 1 Acyltransferase Nro1 PF12753.7 ORX49388.1 - 1.9e-17 63.4 4.8 1.8e-15 56.8 0.0 2.1 1 1 1 2 2 2 2 Nuclear pore complex subunit Nro1 Hep_59 PF07052.11 ORX49388.1 - 4.9 8.0 7.8 1.1 10.0 0.4 2.9 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 Peptidase_M13_N PF05649.13 ORX49389.1 - 1.1e-105 354.5 0.1 1.4e-105 354.2 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 ORX49389.1 - 1.6e-70 236.9 0.0 2.9e-70 236.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 HLH PF00010.26 ORX49390.1 - 8.5e-14 51.3 1.0 1.8e-13 50.2 1.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain ImcF-related_N PF14331.6 ORX49391.1 - 0.051 12.9 0.6 0.051 12.9 0.6 2.1 3 0 0 3 3 3 0 ImcF-related N-terminal domain MCM PF00493.23 ORX49392.1 - 1.2e-103 345.1 0.3 6.3e-103 342.7 0.0 2.0 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 ORX49392.1 - 2.1e-34 118.1 0.1 4.7e-34 117.0 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX49392.1 - 8.1e-28 96.7 0.6 2.2e-27 95.3 0.6 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX49392.1 - 2.6e-16 60.1 0.2 5.5e-16 59.1 0.2 1.5 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX49392.1 - 6e-06 25.8 0.0 0.00057 19.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX49392.1 - 4.4e-05 23.4 0.0 0.00072 19.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX49392.1 - 4.9e-05 23.3 0.0 0.00015 21.7 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX49392.1 - 0.093 12.4 0.0 1.5 8.5 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 ORX49394.1 - 4.8e-49 166.4 0.0 5e-24 85.4 0.0 3.5 2 1 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ORX49394.1 - 3.8e-15 56.5 0.0 0.00015 21.7 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX49394.1 - 1.3e-13 50.9 0.1 0.0011 18.4 0.0 4.1 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 ORX49394.1 - 1.7e-09 37.4 0.4 4.1e-09 36.2 0.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain RsgA_GTPase PF03193.16 ORX49394.1 - 6.5e-08 32.7 0.1 0.0015 18.5 0.1 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 ORX49394.1 - 4e-07 29.7 0.4 0.03 14.1 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX49394.1 - 1e-06 28.8 0.1 0.0096 16.0 0.1 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_23 PF13476.6 ORX49394.1 - 3.3e-06 27.7 9.2 0.0038 17.8 0.0 3.2 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX49394.1 - 1.3e-05 25.6 0.7 0.086 13.2 0.0 3.3 4 0 0 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 ORX49394.1 - 1.5e-05 25.3 0.4 0.3 11.4 0.1 3.9 3 1 0 3 3 3 2 AAA domain AAA_33 PF13671.6 ORX49394.1 - 2.6e-05 24.4 0.1 0.025 14.8 0.0 3.6 2 1 1 3 3 3 1 AAA domain DUF87 PF01935.17 ORX49394.1 - 8.8e-05 22.7 0.9 0.058 13.5 0.7 2.9 2 0 0 2 2 2 1 Helicase HerA, central domain 4HB PF17947.1 ORX49394.1 - 0.00026 21.0 0.0 0.00096 19.2 0.0 2.0 2 0 0 2 2 1 1 Four helical bundle domain CLASP_N PF12348.8 ORX49394.1 - 0.0004 20.0 0.0 0.94 9.0 0.0 2.5 2 0 0 2 2 2 2 CLASP N terminal NACHT PF05729.12 ORX49394.1 - 0.00047 20.1 0.1 0.55 10.1 0.0 2.6 2 0 0 2 2 2 2 NACHT domain AAA_28 PF13521.6 ORX49394.1 - 0.0012 19.1 0.1 0.41 10.9 0.1 2.6 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 ORX49394.1 - 0.0013 17.8 0.6 0.66 8.9 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 ORX49394.1 - 0.0019 17.5 0.0 0.18 11.1 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin Dynamin_N PF00350.23 ORX49394.1 - 0.0026 17.8 0.0 0.85 9.7 0.0 3.1 2 1 1 3 3 3 1 Dynamin family AAA_15 PF13175.6 ORX49394.1 - 0.0037 17.0 0.3 3.5 7.2 0.0 3.2 4 0 0 4 4 3 1 AAA ATPase domain RNA_helicase PF00910.22 ORX49394.1 - 0.0047 17.3 0.2 5 7.6 0.0 3.7 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.6 ORX49394.1 - 0.0059 17.2 0.0 8 7.0 0.0 3.2 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 ORX49394.1 - 0.0075 16.0 0.5 4.6 6.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 ORX49394.1 - 0.01 15.0 0.1 0.48 9.5 0.0 2.8 3 0 0 3 3 2 1 Protein of unknown function (DUF815) Roc PF08477.13 ORX49394.1 - 0.014 15.6 0.0 8.4 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_30 PF13604.6 ORX49394.1 - 0.016 15.0 0.0 2.7 7.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 ORX49394.1 - 0.017 14.7 0.0 2.7 7.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 ORX49394.1 - 0.022 14.3 0.1 1.1 8.8 0.0 2.6 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NB-ARC PF00931.22 ORX49394.1 - 0.035 13.3 0.4 1.2 8.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain Arf PF00025.21 ORX49394.1 - 0.061 12.8 0.1 9.2 5.7 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family G-alpha PF00503.20 ORX49394.1 - 0.066 12.4 0.1 9.1 5.3 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit AAA_13 PF13166.6 ORX49394.1 - 0.092 11.4 2.4 6.4 5.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain Septin PF00735.18 ORX49394.1 - 0.098 11.9 0.0 15 4.7 0.0 2.4 2 0 0 2 2 2 0 Septin cobW PF02492.19 ORX49394.1 - 0.11 12.1 0.7 5.2 6.6 0.0 2.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 ORX49394.1 - 0.15 12.5 0.1 54 4.2 0.0 4.0 4 0 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ORX49394.1 - 0.18 11.7 1.0 30 4.5 0.3 3.0 3 0 0 3 3 3 0 NTPase RTC4 PF14474.6 ORX49396.1 - 1.2e-22 80.3 0.1 3.3e-22 78.9 0.1 1.7 1 0 0 1 1 1 1 RTC4-like domain TipAS PF07739.13 ORX49396.1 - 0.099 13.2 0.1 0.31 11.6 0.0 1.8 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain zf-ribbon_3 PF13248.6 ORX49396.1 - 0.12 11.8 0.1 0.23 10.9 0.1 1.4 1 0 0 1 1 1 0 zinc-ribbon domain MIF4G_like_2 PF09090.11 ORX49397.1 - 1.1e-61 208.7 6.9 1.8e-61 208.0 6.9 1.4 1 0 0 1 1 1 1 MIF4G like MIF4G_like PF09088.11 ORX49397.1 - 1.1e-45 155.8 0.1 2.3e-45 154.7 0.1 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 ORX49397.1 - 2.9e-12 46.7 1.3 7e-12 45.4 0.0 2.3 3 0 0 3 3 3 1 MIF4G domain STAT_alpha PF01017.20 ORX49397.1 - 0.0053 16.7 2.6 0.015 15.2 2.6 1.7 1 0 0 1 1 1 1 STAT protein, all-alpha domain SAP30_Sin3_bdg PF13867.6 ORX49397.1 - 0.14 12.5 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 IZUMO PF15005.6 ORX49397.1 - 0.54 10.8 3.6 17 5.9 2.1 2.7 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated RasGAP_C PF03836.15 ORX49397.1 - 0.68 10.1 5.5 17 5.5 0.1 3.8 3 1 1 4 4 4 0 RasGAP C-terminus Phosphoesterase PF04185.14 ORX49398.1 - 9.6e-30 104.0 7.1 1.1e-28 100.5 7.1 2.0 1 1 0 1 1 1 1 Phosphoesterase family Innate_immun PF12782.7 ORX49398.1 - 0.88 9.0 7.2 1.3 8.5 7.2 1.1 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family RRM_1 PF00076.22 ORX49399.1 - 2.8e-25 87.9 0.9 2.3e-12 46.5 0.1 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX49399.1 - 1.5e-05 24.6 0.1 0.022 14.3 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX49399.1 - 8.2e-05 22.4 0.1 0.0041 16.9 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif DEAD_2 PF06733.15 ORX49400.1 - 1.6e-54 184.2 0.3 2.5e-54 183.5 0.3 1.3 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 ORX49400.1 - 7.5e-43 146.4 3.0 2.1e-36 125.4 1.2 3.4 2 1 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 ORX49400.1 - 5.2e-39 134.2 0.0 1.3e-38 132.8 0.0 1.6 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 ORX49400.1 - 0.00027 21.0 0.0 0.0086 16.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX49400.1 - 0.007 15.8 0.0 0.57 9.6 0.0 2.9 2 1 0 2 2 2 1 PhoH-like protein YtxC PF08812.11 ORX49400.1 - 0.048 13.3 0.2 0.86 9.2 0.1 2.4 2 0 0 2 2 2 0 YtxC-like family DUF2075 PF09848.9 ORX49400.1 - 0.05 12.8 0.0 1.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DUF5550 PF17704.1 ORX49400.1 - 0.07 13.2 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5550) AAA_22 PF13401.6 ORX49400.1 - 0.073 13.3 0.1 8.8 6.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 ORX49400.1 - 0.087 12.6 0.1 2.7 7.7 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase SNF2_N PF00176.23 ORX49400.1 - 0.15 10.7 0.6 3.3 6.3 0.6 2.3 1 1 0 1 1 1 0 SNF2 family N-terminal domain AAA PF00004.29 ORX49400.1 - 0.18 12.3 0.2 19 5.7 0.1 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) tRNA-synt_1e PF01406.19 ORX49401.1 - 8.2e-133 442.4 2.2 1.2e-132 441.8 2.2 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 ORX49401.1 - 2.1e-10 39.9 3.5 2.2e-07 30.0 0.3 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX49401.1 - 5.4e-05 21.6 0.0 0.00019 19.8 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 ORX49401.1 - 0.00026 20.0 0.5 0.0042 16.1 0.1 2.3 2 1 0 2 2 2 1 tRNA synthetases class I (K) DALR_2 PF09190.11 ORX49401.1 - 0.0017 18.8 0.1 0.0059 17.1 0.0 1.9 2 0 0 2 2 2 1 DALR domain tRNA-synt_1c PF00749.21 ORX49401.1 - 0.0098 14.8 0.5 0.029 13.3 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain DUF445 PF04286.12 ORX49401.1 - 0.67 9.7 7.2 0.55 10.0 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF445) MscS_TM PF12794.7 ORX49402.1 - 1.1 8.0 2.6 1.5 7.6 2.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 PET117 PF15786.5 ORX49402.1 - 5.4 7.4 12.6 0.93 9.8 1.2 2.2 2 0 0 2 2 2 0 PET assembly of cytochrome c oxidase, mitochondrial Ribonuc_red_sm PF00268.21 ORX49403.1 - 1.3e-118 395.5 4.6 1.6e-118 395.2 4.6 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain CRAL_TRIO PF00650.20 ORX49405.1 - 3e-33 114.8 0.2 4.3e-33 114.3 0.2 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX49405.1 - 0.00048 20.2 0.1 0.0013 18.9 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX49405.1 - 0.03 14.5 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Cyclin_N PF00134.23 ORX49406.1 - 1.3e-06 28.1 0.0 1.5e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX49406.1 - 0.0002 21.8 0.0 0.00031 21.2 0.0 1.3 1 1 0 1 1 1 1 Cyclin MFS_1 PF07690.16 ORX49407.1 - 2.3e-45 155.1 16.9 3.5e-45 154.4 16.9 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX49407.1 - 2.3e-09 36.6 4.3 2.3e-09 36.6 4.3 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ORX49407.1 - 4.3e-07 28.8 3.6 7.6e-07 27.9 3.6 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 ORX49407.1 - 0.042 12.7 14.4 8.8 5.1 14.4 3.1 1 1 0 1 1 1 0 MFS_1 like family COX6B PF02297.17 ORX49408.1 - 0.0047 17.1 1.1 0.0047 17.1 1.1 2.2 1 1 1 2 2 2 1 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 ORX49408.1 - 0.0073 16.3 3.1 0.011 15.7 3.1 1.4 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like Ndufs5 PF10200.9 ORX49408.1 - 0.018 15.3 1.8 0.035 14.4 1.7 1.6 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa NDUF_B7 PF05676.13 ORX49408.1 - 0.045 13.5 3.9 0.054 13.2 3.5 1.4 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Pet191_N PF10203.9 ORX49408.1 - 0.068 13.5 2.0 0.09 13.1 1.5 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 WASH-7_C PF14746.6 ORX49408.1 - 0.1 12.3 1.1 0.13 12.0 1.1 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal DUF2390 PF09523.10 ORX49408.1 - 0.21 11.9 4.8 0.58 10.5 4.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2390) DUF3128 PF11326.8 ORX49408.1 - 0.61 10.5 7.4 1.5 9.3 7.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) DUF3535 PF12054.8 ORX49409.1 - 6e-99 332.2 0.0 4.3e-98 329.4 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 ORX49409.1 - 6.7e-66 222.4 0.0 2.7e-65 220.4 0.0 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX49409.1 - 3.4e-16 59.6 0.0 9.7e-16 58.1 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 ORX49409.1 - 5.1e-08 32.5 22.2 2.5 8.6 0.1 10.5 10 1 1 11 11 11 2 HEAT repeat ResIII PF04851.15 ORX49409.1 - 0.00015 21.8 0.1 0.00097 19.2 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TAF6_C PF07571.13 ORX49409.1 - 0.00053 20.3 0.0 1.9 8.9 0.0 3.9 4 0 0 4 4 4 2 TAF6 C-terminal HEAT repeat domain Vac14_Fab1_bd PF12755.7 ORX49409.1 - 0.0042 17.7 0.2 20 5.8 0.1 3.9 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX49409.1 - 0.0053 16.8 0.1 5.7 6.9 0.0 4.4 4 0 0 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX49409.1 - 0.026 14.9 3.8 0.25 11.8 0.1 4.5 6 0 0 6 6 6 0 HEAT repeats HEAT_EZ PF13513.6 ORX49409.1 - 0.12 12.9 7.5 38 4.9 0.1 5.8 6 0 0 6 6 6 0 HEAT-like repeat DUF2236 PF09995.9 ORX49410.1 - 0.00024 21.4 0.0 0.00039 20.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) BTB PF00651.31 ORX49411.1 - 6.7e-32 110.0 1.6 1e-14 54.7 0.0 3.5 3 0 0 3 3 3 2 BTB/POZ domain Ank_2 PF12796.7 ORX49411.1 - 2.9e-08 34.2 0.0 7.4e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX49411.1 - 1.6e-07 31.8 0.0 3.7e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX49411.1 - 6.1e-07 29.6 0.0 3.6e-05 24.0 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX49411.1 - 1e-05 25.5 0.0 0.00098 19.4 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ORX49411.1 - 0.0033 17.8 0.0 0.11 13.0 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat BACK PF07707.15 ORX49411.1 - 0.058 13.5 0.1 0.18 11.9 0.1 1.9 1 0 0 1 1 1 0 BTB And C-terminal Kelch KRAB PF01352.27 ORX49411.1 - 0.12 12.1 0.1 0.29 10.8 0.1 1.7 1 0 0 1 1 1 0 KRAB box Xan_ur_permease PF00860.20 ORX49412.1 - 5.1e-25 88.0 33.6 2.8e-23 82.3 33.6 2.2 1 1 0 1 1 1 1 Permease family MFS_MOT1 PF16983.5 ORX49412.1 - 0.0062 16.9 5.4 0.0062 16.9 5.4 3.0 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily EnY2 PF10163.9 ORX49413.1 - 5.8e-20 71.5 0.2 6.6e-20 71.3 0.2 1.0 1 0 0 1 1 1 1 Transcription factor e(y)2 INPP5B_PH PF16776.5 ORX49413.1 - 0.02 14.6 0.0 0.023 14.4 0.0 1.1 1 0 0 1 1 1 0 Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain Phage_Treg PF04761.12 ORX49413.1 - 0.13 12.3 0.2 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Lactococcus bacteriophage putative transcription regulator Acetyltransf_1 PF00583.25 ORX49414.1 - 6.4e-14 52.2 0.0 8.3e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX49414.1 - 5.8e-09 36.0 0.3 7e-09 35.7 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX49414.1 - 4.3e-07 30.3 0.0 6.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX49414.1 - 5.2e-06 26.3 0.0 7.7e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ORX49414.1 - 0.00061 19.9 0.2 0.001 19.1 0.2 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ORX49414.1 - 0.002 17.6 1.1 0.0039 16.7 0.1 1.9 1 1 2 3 3 3 1 Putative acetyl-transferase Glyco_hydro_32N PF00251.20 ORX49414.1 - 0.092 12.3 0.0 0.23 11.0 0.0 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 32 N-terminal domain Acetyltransf_3 PF13302.7 ORX49414.1 - 0.11 13.1 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Xpo1 PF08389.12 ORX49415.1 - 0.00011 22.2 0.7 0.00011 22.2 0.7 3.1 3 1 1 4 4 4 1 Exportin 1-like protein KIND PF16474.5 ORX49415.1 - 0.018 15.0 0.0 0.047 13.6 0.0 1.7 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain HEAT PF02985.22 ORX49415.1 - 0.044 14.0 0.3 1.6 9.2 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat UME PF08064.13 ORX49415.1 - 0.1 12.6 0.3 0.69 9.9 0.3 2.5 1 0 0 1 1 1 0 UME (NUC010) domain BRK PF07533.16 ORX49415.1 - 0.13 11.9 0.1 0.26 10.9 0.1 1.5 1 0 0 1 1 1 0 BRK domain HEAT_EZ PF13513.6 ORX49415.1 - 0.19 12.3 1.1 28 5.3 0.0 3.8 4 0 0 4 4 4 0 HEAT-like repeat Importin_rep_3 PF18806.1 ORX49416.1 - 0.00028 20.9 0.0 0.00041 20.3 0.0 1.3 1 0 0 1 1 1 1 Importin 13 repeat DivIC PF04977.15 ORX49418.1 - 0.0059 16.3 0.5 0.011 15.5 0.5 1.5 1 0 0 1 1 1 1 Septum formation initiator Syntaxin PF00804.25 ORX49418.1 - 0.0065 16.2 0.3 0.0083 15.8 0.3 1.1 1 0 0 1 1 1 1 Syntaxin Cse1 PF08506.10 ORX49418.1 - 0.013 14.3 0.1 0.015 14.2 0.1 1.0 1 0 0 1 1 1 0 Cse1 GIT_CC PF16559.5 ORX49418.1 - 0.016 15.1 0.9 0.032 14.1 0.9 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ORC4_C PF14629.6 ORX49418.1 - 0.018 14.4 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus DUF5082 PF16888.5 ORX49418.1 - 0.05 13.9 1.8 0.11 12.8 1.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Nnf1 PF03980.14 ORX49418.1 - 0.073 13.5 1.8 0.12 12.8 1.8 1.3 1 0 0 1 1 1 0 Nnf1 RuvX PF03652.15 ORX49418.1 - 0.081 13.3 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 Holliday junction resolvase DUF4509 PF14970.6 ORX49418.1 - 0.093 12.6 1.3 0.12 12.3 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) DUF3482 PF11981.8 ORX49418.1 - 0.22 10.9 3.5 0.3 10.4 2.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3482) Cu-oxidase_2 PF07731.14 ORX49419.1 - 8e-09 35.4 0.3 1.6e-08 34.3 0.3 1.5 1 0 0 1 1 1 1 Multicopper oxidase Acetyltransf_1 PF00583.25 ORX49421.1 - 2.4e-11 43.9 0.0 2.7e-11 43.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX49421.1 - 7e-08 32.8 0.0 8.8e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX49421.1 - 1.1e-07 31.8 0.0 1.4e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX49421.1 - 0.0063 16.6 0.0 0.0096 16.0 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ORX49421.1 - 0.037 14.0 0.1 0.058 13.4 0.1 1.3 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase FR47 PF08445.10 ORX49421.1 - 0.045 13.7 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_3 PF13302.7 ORX49421.1 - 0.05 14.3 0.0 0.055 14.1 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ASL_C2 PF14698.6 ORX49423.1 - 4e-18 65.9 0.0 5.4e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Lyase_1 PF00206.20 ORX49424.1 - 4.6e-105 351.5 0.0 6.1e-105 351.1 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 ORX49424.1 - 2.6e-24 85.7 0.1 5.5e-24 84.7 0.1 1.6 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal Acetyltransf_1 PF00583.25 ORX49425.1 - 4e-17 62.5 0.0 4.7e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX49425.1 - 1.5e-14 54.0 0.0 2e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX49425.1 - 4.4e-11 43.1 0.0 6.3e-11 42.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ORX49425.1 - 2.2e-05 25.1 0.0 2.6e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX49425.1 - 0.00061 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_CG PF14542.6 ORX49425.1 - 0.00074 19.6 0.0 0.0012 18.9 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 ORX49425.1 - 0.01 15.8 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_8 PF13523.6 ORX49425.1 - 0.021 14.5 0.0 0.037 13.7 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ORX49425.1 - 0.087 12.4 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase PAGK PF15284.6 ORX49425.1 - 0.16 11.9 0.2 21 5.1 0.0 2.3 2 0 0 2 2 2 0 Phage-encoded virulence factor PLDc PF00614.22 ORX49426.1 - 1.5e-18 66.1 5.2 8.9e-11 41.5 0.2 3.2 3 0 0 3 3 3 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX49426.1 - 9.8e-16 57.9 2.5 2.1e-09 37.3 1.6 3.2 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 ORX49426.1 - 1.1e-09 38.3 0.5 4.1e-09 36.4 0.0 2.3 2 0 0 2 2 2 1 PX domain CoA_transf_3 PF02515.17 ORX49427.1 - 1.3e-68 231.8 0.1 3.6e-68 230.4 0.1 1.6 1 1 0 1 1 1 1 CoA-transferase family III EF-hand_7 PF13499.6 ORX49428.1 - 1.6e-14 54.1 2.9 1.1e-11 45.0 1.8 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX49428.1 - 3.1e-11 42.0 4.5 0.0022 17.4 0.4 3.9 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ORX49428.1 - 6.2e-11 41.3 3.6 0.039 13.9 0.0 3.7 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 ORX49428.1 - 0.00017 21.0 2.8 0.0013 18.1 0.2 3.3 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.7 ORX49428.1 - 0.0014 18.5 3.5 0.24 11.4 0.2 2.5 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Flavodoxin_1 PF00258.25 ORX49428.1 - 0.11 12.7 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Flavodoxin EF-hand_8 PF13833.6 ORX49428.1 - 0.13 12.1 6.3 1.9 8.4 0.8 3.0 1 1 2 3 3 3 0 EF-hand domain pair R3H PF01424.22 ORX49429.1 - 0.0096 15.9 0.0 0.02 14.9 0.0 1.6 1 0 0 1 1 1 1 R3H domain ERG4_ERG24 PF01222.17 ORX49430.1 - 7.4e-133 443.4 19.4 8.4e-133 443.3 19.4 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family RasGEF PF00617.19 ORX49431.1 - 2e-31 109.5 0.0 4.2e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX49431.1 - 3e-14 53.1 1.2 8.7e-14 51.6 1.2 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif zf-HC5HC2H_2 PF13832.6 ORX49432.1 - 4.1e-18 65.6 14.4 5.3e-18 65.2 3.3 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ORX49432.1 - 8.3e-11 42.0 17.7 1.5e-10 41.2 4.5 3.1 2 2 0 2 2 2 1 PHD-like zinc-binding domain PHD_2 PF13831.6 ORX49432.1 - 3.1e-10 39.4 3.5 3.1e-10 39.4 3.5 2.2 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 ORX49432.1 - 1.4e-09 37.7 19.9 9e-08 31.9 7.4 2.6 2 0 0 2 2 2 2 PHD-finger BUD22 PF09073.10 ORX49432.1 - 0.0011 18.4 24.1 0.0017 17.8 24.1 1.3 1 0 0 1 1 1 1 BUD22 FANCL_C PF11793.8 ORX49432.1 - 0.12 12.6 17.5 0.048 13.8 4.3 2.5 2 0 0 2 2 2 0 FANCL C-terminal domain zf-RING-like PF08746.11 ORX49432.1 - 0.15 12.4 18.2 0.19 12.1 6.3 2.6 2 0 0 2 2 2 0 RING-like domain Nop14 PF04147.12 ORX49432.1 - 0.54 8.4 16.9 0.79 7.9 16.9 1.2 1 0 0 1 1 1 0 Nop14-like family zf-UDP PF14569.6 ORX49432.1 - 2.6 8.2 19.8 0.087 12.9 6.7 3.0 2 1 0 2 2 2 0 Zinc-binding RING-finger DNA_pol_phi PF04931.13 ORX49432.1 - 3.1 5.8 24.6 4.3 5.3 24.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.8 ORX49432.1 - 3.8 6.6 9.4 6 5.9 9.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Macoilin PF09726.9 ORX49432.1 - 4.9 5.6 12.2 5.6 5.4 12.2 1.2 1 0 0 1 1 1 0 Macoilin family DUF1192 PF06698.11 ORX49433.1 - 0.14 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF4763 PF15960.5 ORX49433.1 - 0.16 11.3 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) zf-H2C2_2 PF13465.6 ORX49435.1 - 9e-15 54.3 15.9 5.2e-08 33.0 0.8 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX49435.1 - 1.5e-14 53.6 19.0 9.7e-06 25.8 0.8 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX49435.1 - 4.4e-12 45.8 16.7 0.00042 20.9 1.1 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX49435.1 - 1.5e-08 34.4 13.4 2.3e-05 24.2 0.1 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HE PF16278.5 ORX49435.1 - 9e-08 32.5 4.8 0.055 13.9 0.0 3.4 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 ORX49435.1 - 4.5e-05 23.6 4.7 0.72 10.2 0.0 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding Lebercilin PF15619.6 ORX49435.1 - 0.028 14.1 2.5 0.031 13.9 0.6 1.9 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease zf-C2H2_3rep PF18868.1 ORX49435.1 - 0.066 13.9 3.1 4.4 8.0 0.7 2.7 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 ORX49435.1 - 0.12 12.7 5.0 34 4.9 0.1 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) YabA PF06156.13 ORX49435.1 - 0.15 12.7 0.3 0.28 11.8 0.3 1.4 1 0 0 1 1 1 0 Initiation control protein YabA zf-MYST PF17772.1 ORX49435.1 - 0.29 10.8 5.8 3.7 7.2 0.1 2.8 1 1 2 3 3 3 0 MYST family zinc finger domain zinc-ribbons_6 PF07191.12 ORX49435.1 - 1.2 9.2 3.8 13 5.9 3.8 2.2 1 1 0 1 1 1 0 zinc-ribbons DZR PF12773.7 ORX49435.1 - 1.5 8.9 4.7 63 3.7 2.6 2.3 1 1 1 2 2 2 0 Double zinc ribbon C1_4 PF07975.12 ORX49435.1 - 2 8.7 7.9 3.7 7.9 5.8 2.4 1 1 2 3 3 3 0 TFIIH C1-like domain zf-met PF12874.7 ORX49435.1 - 2.2 8.8 9.3 1.9 9.0 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type FYDLN_acid PF09538.10 ORX49435.1 - 3 8.6 5.6 26 5.5 0.3 3.1 2 1 1 3 3 3 0 Protein of unknown function (FYDLN_acid) Zn-ribbon_8 PF09723.10 ORX49435.1 - 3.4 7.9 6.6 49 4.1 0.1 3.1 2 1 1 3 3 3 0 Zinc ribbon domain zf_UBZ PF18439.1 ORX49435.1 - 4.6 6.9 6.5 2.6 7.7 0.4 3.0 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger NAD_kinase PF01513.21 ORX49436.1 - 3.7e-68 229.8 0.0 2.1e-42 145.3 0.0 2.0 2 0 0 2 2 2 2 ATP-NAD kinase SOG2 PF10428.9 ORX49436.1 - 0.73 9.0 6.5 0.36 10.0 3.7 1.8 2 0 0 2 2 2 0 RAM signalling pathway protein ANAPC1 PF12859.7 ORX49436.1 - 0.87 10.2 4.0 2.1 8.9 4.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 GPI-anchored PF10342.9 ORX49437.1 - 3.8e-05 24.4 1.9 4e-05 24.3 0.3 1.8 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Phage_TTP_1 PF04630.12 ORX49437.1 - 0.03 13.6 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 Phage tail tube protein Ribosomal_L24e PF01246.20 ORX49438.1 - 1.4e-31 108.5 7.3 2.9e-31 107.5 7.3 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e Flu_M1 PF00598.19 ORX49438.1 - 0.094 12.2 0.3 0.13 11.8 0.3 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M1) MOZ_SAS PF01853.18 ORX49439.1 - 8.8e-84 279.6 0.7 1.6e-83 278.8 0.2 1.6 2 0 0 2 2 2 1 MOZ/SAS family zf-MYST PF17772.1 ORX49439.1 - 2.4e-22 78.3 2.6 5.7e-22 77.1 2.6 1.7 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 ORX49439.1 - 1.5e-17 63.2 0.0 3.6e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 ORX49439.1 - 0.0014 19.0 0.0 0.003 17.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain HTH_11 PF08279.12 ORX49439.1 - 0.012 15.5 0.5 0.025 14.5 0.5 1.5 1 0 0 1 1 1 0 HTH domain Acetyltransf_1 PF00583.25 ORX49439.1 - 0.02 15.1 0.0 0.053 13.8 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Memo PF01875.17 ORX49440.1 - 4.8e-79 265.3 0.0 5.6e-79 265.1 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein LRR_8 PF13855.6 ORX49441.1 - 2.7e-16 59.1 22.4 2.1e-07 30.6 0.8 3.3 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ORX49441.1 - 2.4e-15 56.4 26.7 5.5e-06 26.6 2.8 4.8 2 1 4 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX49441.1 - 7.9e-05 22.7 17.1 5.2 8.0 0.1 7.7 7 1 1 8 8 8 1 Leucine Rich Repeat LRR_9 PF14580.6 ORX49441.1 - 0.0027 17.2 1.0 0.0062 16.1 0.9 1.6 1 1 0 1 1 1 1 Leucine-rich repeat LRR_6 PF13516.6 ORX49441.1 - 0.39 10.9 15.1 3.8 7.8 0.2 4.6 6 0 0 6 6 6 0 Leucine Rich repeat DUF727 PF05303.12 ORX49442.1 - 1.1e-11 44.7 0.0 1.6e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF727) Speriolin_N PF15058.6 ORX49442.1 - 0.085 12.9 0.6 0.11 12.6 0.6 1.1 1 0 0 1 1 1 0 Speriolin N terminus Thaumatin PF00314.17 ORX49443.1 - 3.5e-49 167.3 16.6 7.4e-49 166.3 16.6 1.5 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 ORX49443.1 - 0.00051 19.4 0.5 0.24 10.7 0.0 2.7 2 1 0 2 2 2 2 Beta-1,3-glucanase Thaumatin PF00314.17 ORX49444.1 - 3.5e-49 167.3 16.6 7.4e-49 166.3 16.6 1.5 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 ORX49444.1 - 0.00051 19.4 0.5 0.24 10.7 0.0 2.7 2 1 0 2 2 2 2 Beta-1,3-glucanase Med21 PF11221.8 ORX49445.1 - 1.4e-21 77.3 1.6 2.2e-21 76.6 1.6 1.3 1 1 0 1 1 1 1 Subunit 21 of Mediator complex Metallophos PF00149.28 ORX49447.1 - 1.4e-39 136.7 0.1 1.8e-39 136.4 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX49447.1 - 2.7e-22 78.9 0.2 5.3e-22 78.0 0.2 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain PHD PF00628.29 ORX49448.1 - 1.2e-08 34.7 13.0 2.3e-08 33.8 13.0 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX49448.1 - 0.0014 18.1 8.5 0.0023 17.5 8.5 1.3 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 ORX49448.1 - 0.0036 17.3 5.0 0.0077 16.2 5.0 1.5 1 0 0 1 1 1 1 CW-type Zinc Finger PHD_3 PF13922.6 ORX49448.1 - 0.02 15.3 1.6 0.02 15.3 1.6 2.4 2 0 0 2 2 2 0 PHD domain of transcriptional enhancer, Asx LETM1 PF07766.13 ORX49449.1 - 4.9e-41 140.9 3.9 8.2e-39 133.6 3.9 2.0 1 1 0 1 1 1 1 LETM1-like protein Polysacc_deac_1 PF01522.21 ORX49450.1 - 1.4e-34 118.7 0.0 2e-34 118.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ORX49450.1 - 0.0051 16.0 0.0 0.025 13.8 0.0 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 zf-met2 PF12907.7 ORX49451.1 - 6.4e-15 55.0 4.3 9.4e-15 54.5 4.3 1.3 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 ORX49451.1 - 2.2e-09 38.0 17.7 2.1e-08 34.9 14.0 2.1 2 0 0 2 2 2 2 4F5 protein family F-box-like PF12937.7 ORX49454.1 - 0.0093 15.8 0.1 0.027 14.4 0.1 1.9 1 0 0 1 1 1 1 F-box-like Vac_ImportDeg PF09783.9 ORX49455.1 - 5e-55 185.7 1.4 5.5e-55 185.6 1.4 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein Pkinase PF00069.25 ORX49456.1 - 7.2e-60 202.6 0.0 1.2e-38 133.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49456.1 - 1.7e-29 102.9 0.0 2.3e-23 82.8 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 ORX49456.1 - 3.4e-15 56.2 0.7 1.3e-14 54.3 0.7 2.1 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 ORX49456.1 - 4e-05 23.1 0.1 0.0013 18.2 0.0 2.4 2 0 0 2 2 2 1 Kinase-like PAS_3 PF08447.12 ORX49456.1 - 4.1e-05 23.8 0.0 8.9e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 PAS fold Haspin_kinase PF12330.8 ORX49456.1 - 0.00083 18.4 0.0 0.0019 17.2 0.0 1.7 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX49456.1 - 0.00084 19.3 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX49456.1 - 0.18 11.4 0.0 0.42 10.2 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Seadorna_VP7 PF07387.11 ORX49456.1 - 0.18 10.8 0.0 0.31 10.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 PAS_9 PF13426.7 ORX49456.1 - 0.19 12.0 0.0 0.49 10.7 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF3591 PF12157.8 ORX49457.1 - 6.4e-166 552.4 0.0 9e-166 551.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) TBP-binding PF09247.11 ORX49457.1 - 4.5e-08 33.2 0.6 1.5e-07 31.6 0.6 1.9 1 0 0 1 1 1 1 TATA box-binding protein binding zf-CCHC_6 PF15288.6 ORX49457.1 - 1.1e-07 31.5 1.0 2.4e-07 30.4 1.0 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ORX49457.1 - 0.26 11.4 2.5 0.56 10.4 2.5 1.5 1 0 0 1 1 1 0 Zinc knuckle SNRNP27 PF08648.12 ORX49458.1 - 2.2e-28 98.1 2.8 5.1e-28 96.9 2.8 1.6 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins ORC6 PF05460.13 ORX49458.1 - 0.096 11.9 18.1 0.11 11.7 18.1 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Presenilin PF01080.17 ORX49458.1 - 0.11 11.3 7.4 0.13 11.0 7.4 1.1 1 0 0 1 1 1 0 Presenilin PPL5 PF18168.1 ORX49458.1 - 0.11 11.7 4.1 0.13 11.5 4.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SMAP PF15477.6 ORX49458.1 - 2.9 8.9 6.1 0.26 12.3 0.8 1.9 2 1 0 2 2 2 0 Small acidic protein family Bystin PF05291.11 ORX49459.1 - 2.1e-46 158.6 2.2 2.3e-46 158.4 2.2 1.0 1 0 0 1 1 1 1 Bystin DUF446 PF04287.12 ORX49459.1 - 0.11 12.5 1.2 0.15 12.2 0.1 1.8 2 0 0 2 2 2 0 tRNA pseudouridine synthase C Acyltransferase PF01553.21 ORX49460.1 - 4.3e-17 62.0 0.0 6.8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase 4HBT PF03061.22 ORX49461.1 - 4.9e-06 26.8 0.0 0.081 13.3 0.0 2.4 2 0 0 2 2 2 2 Thioesterase superfamily DUF1977 PF09320.11 ORX49462.1 - 3.4e-25 88.3 3.3 1.1e-24 86.7 3.3 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 ORX49462.1 - 9e-24 83.4 0.6 2.4e-23 82.0 0.6 1.8 1 0 0 1 1 1 1 DnaJ domain INTS2 PF14750.6 ORX49463.1 - 6e-60 202.9 13.1 1.4e-59 201.7 13.1 1.5 1 1 0 1 1 1 1 Integrator complex subunit 2 GRASP55_65 PF04495.14 ORX49466.1 - 2.2e-12 47.4 0.1 2.8e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 GRASP55/65 PDZ-like domain HATPase_c PF02518.26 ORX49467.1 - 7.5e-28 97.3 0.0 1.5e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX49467.1 - 4.4e-23 81.6 0.1 1.7e-22 79.7 0.0 2.1 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ORX49467.1 - 6.7e-18 64.5 0.0 1.7e-17 63.2 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 ORX49467.1 - 0.02 14.7 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pex14_N PF04695.13 ORX49467.1 - 0.26 11.9 4.9 0.85 10.3 4.9 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FmiP_Thoc5 PF09766.9 ORX49467.1 - 4.8 6.4 8.1 0.13 11.5 0.9 2.0 3 0 0 3 3 3 0 Fms-interacting protein/Thoc5 Pkinase_Tyr PF07714.17 ORX49468.1 - 1e-20 74.1 0.1 2e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ORX49468.1 - 9.5e-17 61.2 0.1 2.1e-16 60.1 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Peripla_BP_1 PF00532.21 ORX49468.1 - 0.0025 17.3 0.0 0.69 9.3 0.0 2.3 2 0 0 2 2 2 2 Periplasmic binding proteins and sugar binding domain of LacI family Sp38 PF07354.12 ORX49468.1 - 1.9 7.9 6.7 3.3 7.1 6.7 1.4 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Ephrin_rec_like PF07699.13 ORX49468.1 - 2.1 8.2 11.5 0.025 14.3 2.0 2.8 3 1 0 3 3 3 0 Putative ephrin-receptor like NCD3G PF07562.14 ORX49468.1 - 3 7.9 9.4 0.31 11.1 2.8 2.5 1 1 2 3 3 3 0 Nine Cysteines Domain of family 3 GPCR zf-RanBP PF00641.18 ORX49469.1 - 1.5e-14 53.0 7.6 8e-08 31.5 0.3 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DZR PF12773.7 ORX49469.1 - 8.6e-05 22.5 11.4 0.00014 21.8 11.4 1.4 1 0 0 1 1 1 1 Double zinc ribbon zf-MIZ PF02891.20 ORX49469.1 - 0.00065 19.4 7.1 0.0097 15.6 1.6 2.4 2 0 0 2 2 2 2 MIZ/SP-RING zinc finger zinc_ribbon_10 PF10058.9 ORX49469.1 - 0.0012 18.5 6.8 0.24 11.2 0.2 3.2 2 1 1 3 3 3 1 Predicted integral membrane zinc-ribbon metal-binding protein Vps36-NZF-N PF16988.5 ORX49469.1 - 0.029 13.7 7.8 0.67 9.4 0.4 2.6 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain OrfB_Zn_ribbon PF07282.11 ORX49469.1 - 0.046 13.6 9.5 1.1 9.3 2.9 2.8 1 1 1 2 2 2 0 Putative transposase DNA-binding domain PHD PF00628.29 ORX49469.1 - 0.056 13.3 13.2 1.2 9.0 0.1 3.9 3 1 0 3 3 3 0 PHD-finger Rubredoxin PF00301.20 ORX49469.1 - 0.19 11.8 0.4 0.19 11.8 0.4 3.5 3 1 1 4 4 4 0 Rubredoxin Ribosomal_L40e PF01020.17 ORX49469.1 - 0.32 10.9 9.0 2.5 8.1 1.5 2.5 2 0 0 2 2 2 0 Ribosomal L40e family Zf_RING PF16744.5 ORX49469.1 - 0.34 11.1 7.2 5.3 7.2 1.0 2.3 2 0 0 2 2 2 0 KIAA1045 RING finger DUF2318 PF10080.9 ORX49469.1 - 0.43 10.7 4.7 3 8.0 0.5 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) Zn-ribbon_8 PF09723.10 ORX49469.1 - 0.45 10.7 11.6 0.65 10.2 4.7 3.0 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.19 ORX49469.1 - 0.5 10.4 7.9 10 6.2 7.9 2.4 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 ORX49469.1 - 0.75 9.4 6.6 12 5.6 0.1 3.3 3 0 0 3 3 3 0 C2H2 type zinc-finger Zn_Tnp_IS1595 PF12760.7 ORX49469.1 - 0.99 9.4 16.8 3.3 7.8 6.9 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 ORX49469.1 - 3.6 7.6 11.0 46 4.1 4.8 3.6 3 1 0 3 3 3 0 PhnA Zinc-Ribbon TackOD1 PF18551.1 ORX49469.1 - 4.3 7.0 12.6 2.6 7.7 1.9 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-Sec23_Sec24 PF04810.15 ORX49469.1 - 4.5 7.4 17.2 1.1 9.4 0.8 3.6 1 1 3 4 4 4 0 Sec23/Sec24 zinc finger DUF35_N PF12172.8 ORX49469.1 - 4.6 7.2 12.9 2.5 8.0 1.6 2.6 2 1 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Prim_Zn_Ribbon PF08273.12 ORX49469.1 - 6.5 7.1 14.8 3.7 7.9 1.8 3.6 1 1 2 3 3 3 0 Zinc-binding domain of primase-helicase DPBB_1 PF03330.18 ORX49470.1 - 3.6e-13 49.6 0.2 4.8e-13 49.2 0.2 1.2 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX49470.1 - 0.00013 21.8 0.1 0.00019 21.2 0.1 1.3 1 1 0 1 1 1 1 Barwin family ProQ_C PF17516.2 ORX49470.1 - 0.059 12.8 0.0 0.095 12.1 0.0 1.4 1 0 0 1 1 1 0 ProQ C-terminal domain GST_N_3 PF13417.6 ORX49475.1 - 2.5e-15 56.7 0.2 1.2e-14 54.5 0.0 2.2 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX49475.1 - 1.4e-05 25.3 0.0 4.8e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX49475.1 - 0.00058 20.2 0.0 0.0013 19.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX49475.1 - 0.11 12.5 0.1 0.45 10.6 0.1 2.1 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX49476.1 - 1.4e-13 51.0 0.0 2.6e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX49476.1 - 4.1e-05 23.8 0.0 7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX49476.1 - 0.02 15.2 0.0 0.049 14.0 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX49476.1 - 0.052 13.6 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Ribosomal_L1 PF00687.21 ORX49477.1 - 1.8e-46 158.4 1.0 2.2e-46 158.2 1.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF3671 PF12420.8 ORX49477.1 - 0.16 12.1 2.5 0.25 11.4 2.4 1.5 1 1 0 1 1 1 0 Protein of unknown function IBR PF01485.21 ORX49478.1 - 4.3e-05 23.7 16.1 4.3e-05 23.7 16.1 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ORX49478.1 - 0.00066 19.5 6.8 0.00066 19.5 6.8 4.5 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX49478.1 - 0.029 14.7 8.1 0.029 14.7 8.1 5.5 5 0 0 5 5 5 0 Ring finger domain CBFB_NFYA PF02045.15 ORX49479.1 - 1.9e-28 98.8 7.9 2.7e-28 98.3 7.9 1.2 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B RAP1 PF07218.11 ORX49480.1 - 8.3 4.5 15.9 13 3.9 15.9 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Arm PF00514.23 ORX49481.1 - 5e-07 29.5 0.6 0.14 12.2 0.0 6.0 6 0 0 6 6 6 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ORX49481.1 - 0.055 13.5 0.3 2.4 8.3 0.0 2.8 2 0 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain HEAT_EZ PF13513.6 ORX49481.1 - 2.2 8.9 4.7 7 7.3 0.1 4.3 5 0 0 5 5 5 0 HEAT-like repeat NPL PF17800.1 ORX49483.1 - 1.2e-16 61.1 0.1 2.7e-16 60.0 0.0 1.6 2 0 0 2 2 2 1 Nucleoplasmin-like domain zf-HC5HC2H_2 PF13832.6 ORX49484.1 - 4.1e-33 113.8 10.1 4.1e-33 113.8 10.1 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 ORX49484.1 - 1.6e-26 93.6 0.0 3.3e-26 92.5 0.0 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 ORX49484.1 - 1e-25 89.8 7.4 1e-25 89.8 7.4 3.0 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.6 ORX49484.1 - 9.4e-15 53.9 3.2 9.4e-15 53.9 3.2 2.8 2 0 0 2 2 2 1 PHD-finger Bromodomain PF00439.25 ORX49484.1 - 2.1e-10 40.5 0.7 3.9e-09 36.5 0.4 2.7 2 0 0 2 2 2 1 Bromodomain PHD PF00628.29 ORX49484.1 - 1.9e-09 37.3 9.1 1.9e-09 37.3 9.1 2.9 3 0 0 3 3 3 2 PHD-finger SBF_like PF13593.6 ORX49485.1 - 4.1e-86 289.1 19.2 4.7e-86 288.9 19.2 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) COX6B PF02297.17 ORX49486.1 - 1.6e-23 82.7 4.3 1.9e-23 82.5 4.3 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Pet191_N PF10203.9 ORX49486.1 - 0.0015 18.8 3.6 0.026 14.8 3.4 2.0 1 1 1 2 2 2 2 Cytochrome c oxidase assembly protein PET191 RRM_1 PF00076.22 ORX49487.1 - 2.2e-11 43.4 0.0 3e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX49487.1 - 0.0072 16.3 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Pyr_redox_2 PF07992.14 ORX49489.1 - 5.4e-18 65.2 0.0 2.2e-12 46.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX49489.1 - 5.7e-05 23.6 0.1 0.039 14.5 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX49489.1 - 0.00041 20.4 0.0 1.3 9.0 0.0 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ORX49489.1 - 0.00044 19.6 0.0 0.038 13.2 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 ORX49489.1 - 0.007 15.7 0.1 2.4 7.3 0.0 2.7 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX49489.1 - 0.016 14.8 0.2 2.3 7.7 0.0 2.8 3 0 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ORX49489.1 - 0.032 13.3 0.0 0.069 12.2 0.0 1.5 1 1 0 1 1 1 0 Lycopene cyclase protein CagD PF16567.5 ORX49489.1 - 0.032 14.0 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Pathogenicity island component CagD FAD_binding_2 PF00890.24 ORX49489.1 - 0.038 13.1 0.0 0.067 12.3 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 ORX49489.1 - 0.039 14.2 0.0 0.088 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX49489.1 - 0.065 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Thi4 family Methyltransf_8 PF05148.15 ORX49490.1 - 7.8e-73 244.9 0.0 8.5e-73 244.8 0.0 1.0 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 ORX49490.1 - 1.2e-06 29.1 0.1 3.5e-06 27.6 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ORX49490.1 - 5.9e-06 25.9 0.1 0.00084 18.9 0.1 2.1 1 1 1 2 2 2 2 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX49490.1 - 2.9e-05 24.7 0.2 0.0011 19.6 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX49490.1 - 4.5e-05 23.3 0.9 0.012 15.4 0.0 2.3 1 1 1 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 ORX49490.1 - 0.00031 20.1 0.3 0.17 11.2 0.0 2.7 1 1 2 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.7 ORX49490.1 - 0.015 15.3 0.2 0.036 14.0 0.2 1.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_29 PF03141.16 ORX49490.1 - 0.077 11.5 0.0 0.61 8.6 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 ORX49490.1 - 0.15 11.7 0.2 0.24 11.0 0.1 1.5 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_11 PF08241.12 ORX49492.1 - 3.6e-14 53.2 0.0 6.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX49492.1 - 1.8e-12 47.8 0.1 9.1e-12 45.5 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX49492.1 - 8e-10 38.7 0.0 1.1e-09 38.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX49492.1 - 5.4e-05 23.9 0.0 0.0001 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ORX49492.1 - 0.00056 19.6 0.2 0.0013 18.4 0.0 1.6 2 0 0 2 2 2 1 Nodulation protein S (NodS) Ubie_methyltran PF01209.18 ORX49492.1 - 0.0029 17.0 0.5 0.029 13.7 0.5 2.0 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family TPMT PF05724.11 ORX49492.1 - 0.069 12.8 0.0 0.15 11.7 0.0 1.8 1 1 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) TPT PF03151.16 ORX49493.1 - 8.2e-29 100.9 24.1 1e-28 100.5 24.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ORX49493.1 - 1.3e-07 31.8 40.9 1.3e-05 25.4 15.6 2.4 2 1 0 2 2 2 2 EamA-like transporter family LcrR PF09621.10 ORX49493.1 - 0.087 12.3 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Type III secretion system regulator (LcrR) GWT1 PF06423.12 ORX49493.1 - 0.13 12.4 4.6 0.088 12.9 1.3 2.3 1 1 1 2 2 2 0 GWT1 Nup84_Nup100 PF04121.13 ORX49494.1 - 2.2e-56 191.4 10.3 8.3e-40 136.6 1.8 2.5 1 1 1 2 2 2 2 Nuclear pore protein 84 / 107 Na_Ca_ex PF01699.24 ORX49495.1 - 2.9e-41 140.9 45.7 3.4e-22 79.0 21.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein MSSP PF03940.13 ORX49497.1 - 0.25 11.0 5.0 0.6 9.7 5.0 1.6 1 0 0 1 1 1 0 Male specific sperm protein NMO PF03060.15 ORX49499.1 - 1.4e-40 139.7 0.0 1.6e-40 139.5 0.0 1.1 1 0 0 1 1 1 1 Nitronate monooxygenase DHO_dh PF01180.21 ORX49499.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase Amidohydro_3 PF07969.11 ORX49500.1 - 1e-20 74.7 1.3 3.3e-13 49.9 0.0 3.4 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_1 PF01979.20 ORX49500.1 - 4e-17 62.6 0.0 2.5e-12 46.8 0.0 3.5 3 1 0 3 3 3 3 Amidohydrolase family Apq12 PF12716.7 ORX49501.1 - 0.0016 18.3 9.7 0.003 17.5 9.7 1.5 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis Cad PF03596.13 ORX49501.1 - 0.038 13.9 5.7 0.054 13.4 5.7 1.2 1 0 0 1 1 1 0 Cadmium resistance transporter AC_N PF16214.5 ORX49501.1 - 0.85 8.7 3.1 0.98 8.5 3.1 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region MAS20 PF02064.15 ORX49502.1 - 8.7e-43 145.5 1.6 1.1e-42 145.2 1.6 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor DUF4381 PF14316.6 ORX49502.1 - 0.068 13.4 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) ARD PF03079.14 ORX49502.1 - 0.083 13.1 0.8 0.11 12.6 0.8 1.2 1 0 0 1 1 1 0 ARD/ARD' family LapA_dom PF06305.11 ORX49502.1 - 0.14 12.0 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain BUD22 PF09073.10 ORX49503.1 - 0.39 10.0 9.3 0.44 9.8 9.3 1.0 1 0 0 1 1 1 0 BUD22 Pacs-1 PF10254.9 ORX49503.1 - 5.7 5.8 6.9 6.4 5.6 6.9 1.0 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Xan_ur_permease PF00860.20 ORX49504.1 - 1.7e-51 175.1 23.5 2.9e-50 171.1 23.5 2.1 1 1 0 1 1 1 1 Permease family DnaJ-X PF14308.6 ORX49505.1 - 7.3e-41 139.9 6.2 7.3e-41 139.9 6.2 1.9 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ORX49505.1 - 8.4e-16 57.8 1.4 1.6e-15 57.0 0.4 2.0 2 0 0 2 2 2 1 DnaJ domain Kelch_5 PF13854.6 ORX49506.1 - 4.7e-20 71.1 0.6 4.2e-07 29.8 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ORX49506.1 - 4.3e-19 68.3 1.0 5.4e-06 26.3 0.0 5.1 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX49506.1 - 2e-17 62.8 0.3 8.5e-05 22.7 0.1 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ORX49506.1 - 1.7e-16 59.4 0.9 0.0049 16.8 0.0 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ORX49506.1 - 4.1e-14 51.9 0.0 0.002 17.6 0.0 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_3 PF13415.6 ORX49506.1 - 7.3e-13 48.5 10.4 4.7e-05 23.6 0.0 6.3 8 0 0 8 8 8 3 Galactose oxidase, central domain Ribosomal_L29 PF00831.23 ORX49507.1 - 1.9e-18 66.2 3.0 1.9e-18 66.2 3.0 2.3 1 1 1 2 2 2 1 Ribosomal L29 protein SprA-related PF12118.8 ORX49507.1 - 0.046 12.8 0.6 0.059 12.5 0.6 1.3 1 0 0 1 1 1 0 SprA-related family DUF4208 PF13907.6 ORX49507.1 - 0.062 13.7 3.2 0.34 11.4 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Annexin PF00191.20 ORX49507.1 - 0.065 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Annexin ATP_sub_h PF10775.9 ORX49508.1 - 9.3e-23 80.0 2.6 1.2e-22 79.7 2.6 1.1 1 0 0 1 1 1 1 ATP synthase complex subunit h MNR PF15718.5 ORX49508.1 - 0.0053 15.0 1.3 0.0057 14.9 1.3 1.0 1 0 0 1 1 1 1 Protein moonraker Glyco_hydro_18 PF00704.28 ORX49509.1 - 4.4e-79 266.4 0.0 5.1e-79 266.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 WD40 PF00400.32 ORX49512.1 - 8.6e-62 203.6 26.0 8.3e-10 39.1 0.5 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX49512.1 - 1.2e-18 67.2 3.3 0.00041 20.6 0.0 5.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX49512.1 - 6e-09 35.1 8.9 0.045 12.4 0.0 6.6 3 2 4 7 7 7 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX49512.1 - 2.1e-07 30.0 1.2 0.2 10.4 0.2 4.5 2 1 2 4 4 4 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 ORX49512.1 - 0.0003 19.4 1.5 1.4 7.4 0.1 3.4 2 1 2 4 4 4 3 Cytochrome D1 heme domain LisH PF08513.11 ORX49512.1 - 0.0015 18.4 0.4 0.004 17.1 0.2 1.9 2 0 0 2 2 2 1 LisH nos_propeller PF18764.1 ORX49512.1 - 0.0019 18.1 0.1 9.8 6.2 0.0 3.6 3 0 0 3 3 3 1 Nitrous oxide reductase propeller repeat Mito_carr PF00153.27 ORX49513.1 - 3.1e-63 209.7 4.6 1.5e-22 79.3 0.4 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Carn_acyltransf PF00755.20 ORX49514.1 - 9.5e-204 678.3 0.0 1.1e-203 678.2 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Vps4_C PF09336.10 ORX49514.1 - 0.0041 17.1 0.1 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain YqeY PF09424.10 ORX49514.1 - 0.063 13.3 0.1 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 Yqey-like protein MHCassoc_trimer PF08831.10 ORX49514.1 - 0.13 12.3 0.2 0.13 12.3 0.2 2.3 3 0 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain WD40 PF00400.32 ORX49515.1 - 1.1e-18 67.2 18.3 2.8e-06 28.0 0.1 7.3 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX49515.1 - 1.8e-16 60.2 6.9 2.1e-06 27.9 0.2 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX49515.1 - 4.5e-09 35.7 0.0 1.2e-05 24.4 0.0 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ORX49515.1 - 0.00011 21.7 0.3 1.3 8.3 0.0 3.9 2 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal IKI3 PF04762.12 ORX49515.1 - 0.27 9.2 4.6 0.47 8.4 0.2 2.4 1 1 0 2 2 2 0 IKI3 family HEAT_EZ PF13513.6 ORX49516.1 - 7.8e-28 96.5 6.0 1.3e-11 44.7 0.0 9.8 9 2 2 11 11 11 5 HEAT-like repeat HEAT PF02985.22 ORX49516.1 - 7.3e-23 78.7 6.4 0.013 15.7 0.1 10.0 9 0 0 9 9 8 4 HEAT repeat HEAT_2 PF13646.6 ORX49516.1 - 5.7e-13 49.1 0.0 0.05 14.0 0.0 6.5 4 2 2 6 6 6 4 HEAT repeats IBN_N PF03810.19 ORX49516.1 - 6.2e-12 45.3 0.0 2.4e-11 43.4 0.0 2.1 2 0 0 2 2 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 ORX49516.1 - 3.2e-09 37.2 0.0 0.0089 16.6 0.1 5.6 5 1 1 6 6 5 2 Vacuolar 14 Fab1-binding region Arm PF00514.23 ORX49516.1 - 8.7e-09 35.1 1.7 0.62 10.2 0.0 6.5 6 0 0 6 6 6 3 Armadillo/beta-catenin-like repeat Cnd1 PF12717.7 ORX49516.1 - 2.4e-07 31.0 0.1 4.1 7.4 0.0 4.7 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ORX49516.1 - 7.4e-07 28.1 0.1 0.0016 17.1 0.0 3.8 3 2 1 4 4 4 2 Adaptin N terminal region TIP120 PF08623.10 ORX49516.1 - 4.3e-06 26.6 0.0 0.044 13.6 0.0 3.9 4 0 0 4 4 4 1 TATA-binding protein interacting (TIP20) RTP1_C1 PF10363.9 ORX49516.1 - 0.0001 22.5 0.0 0.01 16.0 0.0 4.1 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 MMS19_C PF12460.8 ORX49516.1 - 0.0018 17.5 3.2 1.2 8.1 0.0 4.5 3 2 2 5 5 5 1 RNAPII transcription regulator C-terminal RasGEF_N_2 PF14663.6 ORX49516.1 - 0.0023 18.3 1.1 0.13 12.7 0.0 3.5 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain ParcG PF10274.9 ORX49516.1 - 0.029 14.5 0.4 8.7 6.4 0.1 3.9 3 1 0 4 4 4 0 Parkin co-regulated protein Tti2 PF10521.9 ORX49516.1 - 0.035 13.6 0.1 1.4 8.4 0.0 3.2 1 1 2 3 3 3 0 Tti2 family MMS19_N PF14500.6 ORX49516.1 - 0.058 13.0 0.2 2.7 7.5 0.0 3.4 4 1 0 4 4 4 0 Dos2-interacting transcription regulator of RNA-Pol-II MHCassoc_trimer PF08831.10 ORX49516.1 - 0.079 13.0 0.5 7.2 6.7 0.0 3.8 4 0 0 4 4 4 0 Class II MHC-associated invariant chain trimerisation domain TAF6_C PF07571.13 ORX49516.1 - 0.13 12.7 0.0 8.9 6.7 0.0 3.7 4 0 0 4 4 4 0 TAF6 C-terminal HEAT repeat domain Cohesin_HEAT PF12765.7 ORX49516.1 - 0.26 11.6 1.1 19 5.7 0.0 3.6 4 0 0 4 4 3 0 HEAT repeat associated with sister chromatid cohesion RNA_pol_3_Rpc31 PF11705.8 ORX49516.1 - 0.99 9.6 7.8 1.6 8.9 7.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 N6_N4_Mtase PF01555.18 ORX49517.1 - 2.1e-11 44.0 0.0 0.0002 21.2 0.0 3.1 3 0 0 3 3 3 2 DNA methylase zf-HC5HC2H PF13771.6 ORX49517.1 - 9.8e-10 38.6 3.4 9.8e-10 38.6 3.4 3.6 3 1 1 4 4 4 1 PHD-like zinc-binding domain Tudor_4 PF18358.1 ORX49517.1 - 3e-08 33.1 5.6 3.3e-06 26.6 0.1 4.1 4 0 0 4 4 4 1 Histone methyltransferase Tudor domain zf-HC5HC2H_2 PF13832.6 ORX49517.1 - 2.2e-07 31.0 4.0 2.2e-07 31.0 4.0 3.1 3 0 0 3 3 3 1 PHD-zinc-finger like domain Agenet PF05641.12 ORX49517.1 - 6e-06 26.6 2.2 0.00074 19.9 0.0 3.9 3 0 0 3 3 3 1 Agenet domain MBT PF02820.18 ORX49517.1 - 3e-05 24.3 0.8 0.18 12.2 0.1 3.7 3 0 0 3 3 3 2 mbt repeat Ripply PF14998.6 ORX49517.1 - 0.12 13.0 0.5 9.3 7.0 0.0 3.7 3 0 0 3 3 3 0 Transcription Regulator C1_2 PF03107.16 ORX49517.1 - 0.18 12.2 26.5 0.18 12.2 0.9 4.4 3 0 0 3 3 3 0 C1 domain HEXIM PF15313.6 ORX49517.1 - 0.81 9.9 4.5 7 6.8 2.6 3.2 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein GATA PF00320.27 ORX49517.1 - 0.95 9.1 11.6 0.065 12.9 2.1 3.4 4 0 0 4 4 4 0 GATA zinc finger Gag_p10 PF02337.17 ORX49518.1 - 0.14 12.1 0.3 0.4 10.6 0.2 1.8 2 0 0 2 2 2 0 Retroviral GAG p10 protein TyrRSs_C PF16714.5 ORX49519.1 - 0.05 13.4 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Tyrosyl-tRNA synthetase C-terminal domain GFA PF04828.14 ORX49520.1 - 0.0067 16.7 0.2 0.0075 16.6 0.2 1.1 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme VTC PF09359.10 ORX49521.1 - 2e-90 302.9 0.3 4.5e-90 301.8 0.0 1.7 2 0 0 2 2 2 1 VTC domain SPX PF03105.19 ORX49521.1 - 8.7e-13 48.9 11.3 9.2e-08 32.4 0.0 4.0 2 1 2 4 4 4 3 SPX domain DUF202 PF02656.15 ORX49521.1 - 6e-12 45.8 1.1 1.2e-11 44.9 1.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) zf-C2H2 PF00096.26 ORX49522.1 - 9.8e-11 41.5 21.3 7.8e-06 26.1 2.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX49522.1 - 1e-07 32.2 22.0 0.00039 21.0 1.0 4.0 4 0 0 4 4 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX49522.1 - 3.2e-05 24.2 14.0 0.019 15.4 0.5 3.9 4 0 0 4 4 4 2 Zinc-finger double domain zf-Di19 PF05605.12 ORX49522.1 - 0.00024 21.3 7.8 0.006 16.9 2.3 2.4 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ORX49522.1 - 0.00037 20.4 10.4 0.0012 18.8 0.1 3.4 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX49522.1 - 0.012 15.8 11.3 0.018 15.3 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding NAM-associated PF14303.6 ORX49522.1 - 0.016 15.9 4.3 0.025 15.3 4.3 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain zf-Sec23_Sec24 PF04810.15 ORX49522.1 - 0.021 14.9 4.7 12 6.0 0.0 3.4 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger zf-met PF12874.7 ORX49522.1 - 0.078 13.4 0.2 0.078 13.4 0.2 4.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type BolA PF01722.18 ORX49522.1 - 0.14 12.4 1.8 2.2 8.6 0.7 2.8 1 1 2 3 3 3 0 BolA-like protein C1_4 PF07975.12 ORX49522.1 - 0.3 11.4 9.1 5.4 7.3 4.2 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain Elf1 PF05129.13 ORX49522.1 - 0.37 10.9 9.5 0.74 9.9 5.0 2.5 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_3rep PF18868.1 ORX49522.1 - 0.66 10.7 9.5 9 7.0 2.2 3.2 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 ORX49522.1 - 2.8 8.3 9.3 5.3 7.4 0.1 3.3 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) Presenilin PF01080.17 ORX49522.1 - 3.6 6.2 4.0 5.2 5.7 4.0 1.1 1 0 0 1 1 1 0 Presenilin SEP PF08059.13 ORX49523.1 - 3e-24 85.4 0.0 9e-24 83.8 0.0 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 ORX49523.1 - 1.7e-19 69.8 0.0 3e-19 69.0 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ORX49523.1 - 2.7e-17 62.3 0.1 4.6e-17 61.5 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ORX49523.1 - 0.017 14.8 0.1 0.044 13.4 0.1 1.7 2 0 0 2 2 2 0 TAP C-terminal domain RGS PF00615.19 ORX49524.1 - 1.1e-06 28.9 0.1 0.00053 20.3 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Bax1-I PF01027.20 ORX49525.1 - 1.1e-08 35.2 18.3 1.3e-08 34.9 18.3 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 RabGAP-TBC PF00566.18 ORX49526.1 - 4.9e-22 78.6 0.2 7.2e-22 78.1 0.2 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain JAB PF01398.21 ORX49527.1 - 6.2e-14 52.0 0.0 4.9e-13 49.1 0.0 2.2 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease zf-H2C2_2 PF13465.6 ORX49528.1 - 2.9e-20 71.7 21.6 2.6e-07 30.7 3.1 5.1 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX49528.1 - 6.8e-19 67.2 25.7 8.9e-05 22.7 0.3 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX49528.1 - 1.2e-11 44.4 24.2 0.014 16.1 2.2 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger FOXP-CC PF16159.5 ORX49528.1 - 1.6e-09 38.2 9.0 0.083 13.5 0.0 4.1 2 1 2 4 4 4 3 FOXP coiled-coil domain zf-met PF12874.7 ORX49528.1 - 1.2e-07 31.9 6.3 0.049 14.0 0.7 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX49528.1 - 0.00017 21.8 6.6 0.38 11.1 0.6 3.5 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ORX49528.1 - 0.0045 17.3 8.6 0.17 12.2 6.2 2.6 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-H2C2_5 PF13909.6 ORX49528.1 - 0.4 10.5 0.1 0.4 10.5 0.1 4.7 4 1 0 4 4 4 0 C2H2-type zinc-finger domain zf-MYST PF17772.1 ORX49528.1 - 0.68 9.6 6.6 7.7 6.2 0.6 3.4 2 1 1 3 3 3 0 MYST family zinc finger domain C1_4 PF07975.12 ORX49528.1 - 1.1 9.6 6.3 0.45 10.8 1.7 2.3 2 1 0 2 2 2 0 TFIIH C1-like domain SET PF00856.28 ORX49529.1 - 2.4e-08 34.5 0.0 1.1e-07 32.4 0.0 2.1 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ORX49529.1 - 0.011 15.8 14.9 0.011 15.8 14.9 2.7 2 0 0 2 2 2 0 MYND finger DNA_ligase_A_M PF01068.21 ORX49530.1 - 6.4e-15 55.3 0.0 9.5e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ORX49530.1 - 3.1e-06 27.6 0.0 4.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 RNA ligase DNA_ligase_OB_2 PF14743.6 ORX49530.1 - 1.1e-05 25.3 0.0 2.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 DNA ligase OB-like domain DNA_ligase_A_N PF04675.14 ORX49530.1 - 0.069 13.5 0.0 0.17 12.2 0.0 1.6 1 1 0 1 1 1 0 DNA ligase N terminus mRNA_cap_enzyme PF01331.19 ORX49530.1 - 0.082 12.7 0.0 0.92 9.3 0.0 2.1 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain DUF758 PF05527.11 ORX49530.1 - 0.13 12.2 0.1 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF758) HLH PF00010.26 ORX49532.1 - 2.2e-18 66.0 1.4 3.7e-18 65.2 0.1 1.9 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain Bcr-Abl_Oligo PF09036.10 ORX49532.1 - 0.17 11.9 0.8 0.69 9.9 0.1 2.3 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Pkinase PF00069.25 ORX49533.1 - 5.1e-73 245.7 0.2 6.1e-73 245.4 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49533.1 - 4.1e-36 124.6 0.2 5.6e-36 124.2 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49533.1 - 1.1e-10 41.3 0.0 2.7e-10 40.0 0.0 1.6 1 1 1 2 2 2 1 Kinase-like FTA2 PF13095.6 ORX49533.1 - 4.2e-05 23.3 0.1 0.054 13.1 0.1 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX49533.1 - 0.001 18.1 0.5 0.0019 17.2 0.3 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX49533.1 - 0.038 13.3 0.2 0.08 12.3 0.2 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Act-Frag_cataly PF09192.10 ORX49533.1 - 0.054 12.9 0.5 0.094 12.1 0.5 1.3 1 0 0 1 1 1 0 Actin-fragmin kinase, catalytic APH PF01636.23 ORX49533.1 - 0.13 12.2 0.3 1.2 9.0 0.3 2.2 1 1 0 1 1 1 0 Phosphotransferase enzyme family HEAT PF02985.22 ORX49534.1 - 6.3e-45 147.3 20.2 6.7e-05 22.8 0.0 13.6 14 0 0 14 14 14 9 HEAT repeat HEAT_2 PF13646.6 ORX49534.1 - 5.4e-38 129.3 5.5 1.8e-08 34.7 0.0 7.4 2 2 5 7 7 7 7 HEAT repeats HEAT_EZ PF13513.6 ORX49534.1 - 8.8e-11 42.1 12.2 8.3e-05 23.0 0.1 8.3 9 1 1 10 10 10 3 HEAT-like repeat Adaptin_N PF01602.20 ORX49534.1 - 2.6e-10 39.5 8.0 6e-06 25.1 0.5 4.0 2 1 1 3 3 3 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX49534.1 - 2.5e-09 37.6 0.6 0.72 10.5 0.0 6.0 4 3 1 5 5 5 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX49534.1 - 1.6e-07 31.5 4.9 0.087 12.9 0.0 5.1 2 1 3 5 5 5 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX49534.1 - 9.1e-06 25.4 0.3 0.19 11.3 0.2 4.6 2 2 2 4 4 4 1 CLASP N terminal DNA_alkylation PF08713.11 ORX49534.1 - 1.1e-05 25.3 0.4 0.36 10.5 0.0 3.9 2 1 1 3 3 3 2 DNA alkylation repair enzyme DUF1308 PF07000.11 ORX49534.1 - 0.025 14.5 0.1 0.053 13.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1308) ERAP1_C PF11838.8 ORX49534.1 - 0.028 14.0 0.4 0.075 12.6 0.4 1.8 1 1 0 1 1 1 0 ERAP1-like C-terminal domain HEAT_PBS PF03130.16 ORX49534.1 - 0.05 14.3 5.7 0.28 12.0 0.0 5.1 6 0 0 6 6 5 0 PBS lyase HEAT-like repeat API5 PF05918.11 ORX49534.1 - 0.091 11.6 1.4 1.2 7.9 0.1 2.9 3 1 0 3 3 3 0 Apoptosis inhibitory protein 5 (API5) FliT PF05400.13 ORX49534.1 - 0.23 12.3 1.7 1.1 10.1 0.4 2.7 3 0 0 3 3 3 0 Flagellar protein FliT CH PF00307.31 ORX49535.1 - 2.3e-06 27.7 0.0 3.2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain RasGAP PF00616.19 ORX49536.1 - 7.6e-49 166.2 2.7 1.6e-48 165.1 2.7 1.6 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX49536.1 - 4.1e-33 114.4 3.4 4.3e-33 114.4 0.5 2.4 2 0 0 2 2 2 1 RasGAP C-terminus NHR2 PF08788.11 ORX49536.1 - 0.053 13.3 0.4 0.91 9.3 0.0 3.1 3 0 0 3 3 3 0 NHR2 domain like Pkinase PF00069.25 ORX49538.1 - 4.4e-71 239.3 0.0 5.8e-71 238.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49538.1 - 1e-30 106.9 0.0 1.5e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX49538.1 - 0.00042 19.4 0.1 0.00066 18.7 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX49538.1 - 0.067 13.1 0.0 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX49538.1 - 0.087 12.2 0.1 0.17 11.2 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CAP_GLY PF01302.25 ORX49539.1 - 8e-19 67.4 0.4 1.5e-18 66.6 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_8 PF13855.6 ORX49539.1 - 1.1e-10 41.1 19.4 7.1e-06 25.7 1.0 4.8 4 1 1 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 ORX49539.1 - 3e-10 40.2 29.3 3.4e-05 24.1 5.3 5.9 1 1 7 8 8 8 6 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX49539.1 - 2.7e-08 33.5 6.8 1.7e-05 24.4 0.3 3.3 1 1 2 3 3 3 2 Leucine-rich repeat ubiquitin PF00240.23 ORX49539.1 - 0.017 14.8 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin family LRR_1 PF00560.33 ORX49539.1 - 0.78 10.5 17.2 1.4 9.8 0.3 5.9 6 1 1 7 7 7 0 Leucine Rich Repeat FNIP PF05725.12 ORX49539.1 - 0.85 9.8 4.9 16 5.8 0.7 3.1 3 0 0 3 3 3 0 FNIP Repeat FA_desaturase PF00487.24 ORX49540.1 - 2.5e-15 57.0 9.1 3.3e-15 56.6 9.1 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Eaf7 PF07904.13 ORX49541.1 - 1.5e-23 83.2 0.3 1.5e-23 83.2 0.3 1.8 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 MSA-2c PF12238.8 ORX49541.1 - 0.16 12.0 3.2 0.22 11.5 3.2 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c DUF4551 PF15087.6 ORX49541.1 - 1.9 7.2 8.7 2.1 7.1 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) WDCP PF15390.6 ORX49541.1 - 2.4 6.5 4.3 2.6 6.3 4.3 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family ATP_transf PF09830.9 ORX49542.1 - 4.7e-19 68.3 0.0 8.6e-19 67.4 0.0 1.5 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 ORX49542.1 - 0.0052 17.5 0.0 0.021 15.6 0.0 2.1 1 0 0 1 1 1 1 HIT domain DUF4931 PF16285.5 ORX49542.1 - 0.054 12.8 0.0 0.12 11.6 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) Rhomboid PF01694.22 ORX49545.1 - 0.0011 19.0 4.2 0.0016 18.5 4.2 1.2 1 0 0 1 1 1 1 Rhomboid family DUF692 PF05114.13 ORX49546.1 - 0.21 10.7 0.0 0.26 10.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF692) Auts2 PF15336.6 ORX49547.1 - 0.049 13.7 0.0 0.059 13.5 0.0 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein zf-RVT PF13966.6 ORX49548.1 - 5.4e-10 39.9 0.3 9.3e-10 39.1 0.3 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Metallophos PF00149.28 ORX49549.1 - 9.1e-10 39.4 2.3 1.3e-09 38.9 2.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SAP130_C PF16014.5 ORX49551.1 - 1 8.4 11.8 1.2 8.1 11.8 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus OrfB_Zn_ribbon PF07282.11 ORX49553.1 - 0.0017 18.2 0.4 0.0036 17.2 0.4 1.6 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Anti-TRAP PF15777.5 ORX49553.1 - 0.043 13.8 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein TF_Zn_Ribbon PF08271.12 ORX49553.1 - 0.06 12.9 0.0 0.16 11.5 0.0 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding DUF678 PF05077.12 ORX49553.1 - 0.08 13.1 0.3 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Lar_restr_allev PF14354.6 ORX49553.1 - 0.11 12.9 0.2 0.31 11.5 0.2 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar Wtap PF17098.5 ORX49555.1 - 0.013 15.5 1.6 0.021 14.8 0.3 1.7 1 1 1 2 2 2 0 WTAP/Mum2p family Laminin_I PF06008.14 ORX49555.1 - 0.044 13.5 1.4 0.064 12.9 1.4 1.2 1 0 0 1 1 1 0 Laminin Domain I HTH_32 PF13565.6 ORX49765.1 - 2.8e-07 31.1 0.0 3.3e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ORX49765.1 - 4.6e-05 23.5 0.1 7.2e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ORX49765.1 - 5.8e-05 23.0 0.0 0.00014 21.8 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 ORX49765.1 - 0.0047 16.7 0.0 0.0084 15.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX49765.1 - 0.052 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) EF-hand_7 PF13499.6 ORX49766.1 - 1.9e-17 63.5 0.7 6.5e-12 45.7 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ORX49766.1 - 8.9e-15 53.1 0.6 1.2e-05 24.5 0.0 3.7 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ORX49766.1 - 6.4e-13 47.5 0.7 1.2e-05 24.8 0.1 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ORX49766.1 - 2.2e-08 33.8 1.2 1.5e-07 31.2 0.3 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 ORX49766.1 - 4.2e-06 27.0 0.2 0.0056 17.0 0.0 2.5 2 1 1 3 3 3 2 EF-hand domain EF-hand_11 PF08976.11 ORX49766.1 - 1.4e-05 25.8 0.0 2.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ORX49766.1 - 6.3e-05 22.3 0.3 0.0012 18.3 0.0 3.0 3 0 0 3 3 3 1 EF hand UPF0154 PF03672.13 ORX49766.1 - 0.14 12.2 0.0 0.93 9.6 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) SapB_1 PF05184.15 ORX49766.1 - 0.29 11.2 1.4 7.6 6.7 0.0 2.5 3 0 0 3 3 3 0 Saposin-like type B, region 1 Pkinase PF00069.25 ORX49767.1 - 1.5e-62 211.4 0.0 2.1e-62 210.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49767.1 - 1e-46 159.3 0.0 1.5e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EVI2A PF05399.11 ORX49767.1 - 0.76 9.3 4.8 1.3 8.5 4.8 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Ndc1_Nup PF09531.10 ORX49767.1 - 8.6 4.9 10.9 12 4.4 10.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UBA PF00627.31 ORX49769.1 - 8.3e-08 32.0 0.1 1.3e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 UBA/TS-N domain UBA_4 PF14555.6 ORX49769.1 - 1.3e-05 24.9 0.1 2.2e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain Asp_protease PF09668.10 ORX49770.1 - 1e-15 57.6 0.0 2.1e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 ORX49770.1 - 3.3e-11 42.8 0.1 6.6e-11 41.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX49770.1 - 8.1e-08 32.0 0.7 1.3e-07 31.3 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like XPC-binding PF09280.11 ORX49770.1 - 4.9e-06 26.2 4.1 4.9e-06 26.2 4.1 2.2 2 0 0 2 2 2 1 XPC-binding domain gag-asp_proteas PF13975.6 ORX49770.1 - 9e-06 26.2 0.2 3.3e-05 24.3 0.0 2.0 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Ubiquitin_2 PF14560.6 ORX49770.1 - 2e-05 24.9 0.1 4.8e-05 23.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain Asp_protease_2 PF13650.6 ORX49770.1 - 0.00019 22.0 0.0 0.00049 20.7 0.0 1.7 1 0 0 1 1 1 1 Aspartyl protease Ubiquitin_4 PF18036.1 ORX49770.1 - 0.0005 20.1 0.2 1.2 9.2 0.0 2.5 1 1 1 2 2 2 2 Ubiquitin-like domain UN_NPL4 PF11543.8 ORX49770.1 - 0.0013 19.1 0.0 0.0023 18.4 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 RVP PF00077.20 ORX49770.1 - 0.0032 17.8 0.0 0.0078 16.5 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease DUF5401 PF17380.2 ORX49770.1 - 0.14 10.2 5.4 0.16 10.0 5.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) CCAP PF11105.8 ORX49770.1 - 0.52 10.3 3.1 0.38 10.7 1.3 1.6 2 0 0 2 2 2 0 Arthropod cardioacceleratory peptide 2a Ank_2 PF12796.7 ORX49771.1 - 3.2e-14 53.3 1.4 1.2e-07 32.2 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) TIG PF01833.24 ORX49771.1 - 1.3e-09 37.9 0.0 4.7e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 IPT/TIG domain Ank PF00023.30 ORX49771.1 - 3.6e-08 33.5 0.7 0.0009 19.6 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ORX49771.1 - 3.9e-08 33.7 0.2 1.7e-07 31.6 0.1 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX49771.1 - 9.2e-07 29.0 0.1 1.4e-05 25.3 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX49771.1 - 0.00078 19.7 0.3 0.12 13.0 0.1 3.1 3 0 0 3 3 3 1 Ankyrin repeat NIBRIN_BRCT_II PF16508.5 ORX49772.1 - 8.3e-14 51.9 0.0 1.8e-13 50.8 0.0 1.6 1 0 0 1 1 1 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 ORX49772.1 - 2.7e-08 34.0 0.0 2.5e-07 30.9 0.0 2.3 2 0 0 2 2 2 1 FHA domain GTP_EFTU PF00009.27 ORX49773.1 - 1.1e-52 178.5 0.0 1.9e-52 177.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 ORX49773.1 - 7.1e-46 154.8 2.7 1.9e-45 153.4 1.8 2.1 2 0 0 2 2 2 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ORX49773.1 - 1e-22 79.9 0.1 3.2e-22 78.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus RF3_C PF16658.5 ORX49773.1 - 1.6e-07 31.2 0.0 3.1e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain GTP_EFTU_D2 PF03144.25 ORX49773.1 - 1.4e-06 28.6 0.9 3.2e-06 27.4 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX49773.1 - 2.3e-05 24.5 0.0 7.3e-05 22.8 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase EFG_II PF14492.6 ORX49773.1 - 4.9e-05 23.3 0.0 0.00011 22.2 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II Ras PF00071.22 ORX49773.1 - 0.00011 21.9 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ORX49773.1 - 0.003 17.0 0.0 0.0087 15.5 0.0 1.9 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit UCH PF00443.29 ORX49775.1 - 1.2e-63 215.1 0.8 1.4e-63 214.8 0.8 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX49775.1 - 1.6e-31 110.1 8.1 2.6e-30 106.1 8.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ORX49775.1 - 0.0013 18.3 11.6 0.022 14.3 6.6 3.3 2 1 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF3601 PF12208.8 ORX49775.1 - 0.072 13.2 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3601) MatE PF01554.18 ORX49776.1 - 3.6e-59 199.0 24.7 2.5e-33 115.0 8.0 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ORX49776.1 - 5.8e-09 36.2 9.8 5.8e-09 36.2 9.8 3.4 3 2 0 3 3 3 2 Polysaccharide biosynthesis C-terminal domain DUF2269 PF10027.9 ORX49776.1 - 0.00024 21.2 1.2 0.00024 21.2 1.2 2.6 2 1 1 3 3 3 1 Predicted integral membrane protein (DUF2269) UPF0242 PF06785.11 ORX49776.1 - 0.011 15.9 0.2 0.021 14.9 0.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2244 PF10003.9 ORX49776.1 - 1.5 8.5 5.5 0.54 9.9 0.1 2.8 3 0 0 3 3 3 0 Integral membrane protein (DUF2244) XAP5 PF04921.14 ORX49778.1 - 1.5e-84 283.7 9.9 1.5e-84 283.7 9.9 1.8 1 1 1 2 2 2 1 XAP5, circadian clock regulator CPSase_L_D2 PF02786.17 ORX49779.1 - 1.5e-79 266.4 0.3 3.2e-79 265.3 0.3 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 ORX49779.1 - 8.2e-69 231.3 0.0 1.4e-68 230.6 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 ORX49779.1 - 5.5e-38 129.9 0.1 1.2e-37 128.9 0.1 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX49779.1 - 7.1e-31 106.5 0.0 2e-30 105.1 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 ORX49779.1 - 5.2e-30 104.9 0.0 1.1e-29 103.9 0.0 1.5 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 ORX49779.1 - 2.5e-17 62.5 4.9 9e-17 60.7 1.2 2.6 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX49779.1 - 3.1e-10 40.0 0.0 6e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX49779.1 - 1.5e-07 31.2 0.1 3.2e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ORX49779.1 - 1.7e-07 31.0 0.3 0.018 14.8 0.0 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 ORX49779.1 - 2.9e-06 27.9 3.9 0.019 15.6 0.1 3.9 4 0 0 4 4 4 2 HlyD family secretion protein HlyD_D23 PF16576.5 ORX49779.1 - 0.00023 20.4 0.1 0.27 10.4 0.0 2.5 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion ATP-grasp_3 PF02655.14 ORX49779.1 - 0.00038 20.5 0.0 0.0011 19.0 0.0 1.8 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 ORX49779.1 - 0.00073 19.2 0.1 0.0073 15.9 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 ORX49779.1 - 0.0061 15.8 0.0 0.022 14.0 0.0 1.8 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp GCV_H PF01597.19 ORX49779.1 - 0.017 15.0 0.6 0.39 10.6 0.4 2.8 2 1 1 3 3 3 0 Glycine cleavage H-protein DUF3182 PF11379.8 ORX49779.1 - 0.097 11.6 0.0 0.23 10.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3182) PNPase PF03726.14 ORX49779.1 - 0.27 11.7 1.3 0.73 10.4 0.2 2.3 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain KAR9 PF08580.10 ORX49780.1 - 4.4e-10 38.8 7.7 6.8e-09 34.9 4.7 4.9 1 1 3 5 5 4 2 Yeast cortical protein KAR9 GAS2 PF02187.17 ORX49780.1 - 1e-05 25.5 0.2 6.8e-05 22.9 0.1 2.4 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain FadA PF09403.10 ORX49780.1 - 0.0026 18.2 0.1 0.047 14.2 0.3 2.4 2 0 0 2 2 2 1 Adhesion protein FadA Myb_DNA-bind_4 PF13837.6 ORX49780.1 - 0.0049 17.2 0.7 1.3 9.4 0.3 3.0 2 1 1 3 3 3 1 Myb/SANT-like DNA-binding domain Baculo_PEP_C PF04513.12 ORX49780.1 - 0.025 14.6 4.0 1 9.4 0.6 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.11 ORX49780.1 - 0.075 12.9 1.6 0.17 11.7 1.6 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF148 PF02520.17 ORX49780.1 - 0.22 11.6 2.3 1.2 9.3 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF148 Med9 PF07544.13 ORX49780.1 - 0.25 11.5 7.0 5.6 7.1 0.0 3.5 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Laminin_II PF06009.12 ORX49780.1 - 0.47 10.5 6.1 22 5.1 1.8 3.2 2 1 1 3 3 3 0 Laminin Domain II DUF948 PF06103.11 ORX49780.1 - 1.2 9.4 2.4 5.6 7.3 1.9 2.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lebercilin PF15619.6 ORX49780.1 - 1.6 8.4 7.5 0.45 10.2 3.8 1.9 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF1664 PF07889.12 ORX49780.1 - 4.4 7.4 5.6 11 6.1 3.8 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) IF-2B PF01008.17 ORX49781.1 - 6.8e-63 212.5 0.1 3e-62 210.4 0.1 1.8 1 1 0 1 1 1 1 Initiation factor 2 subunit family Imm49 PF15575.6 ORX49781.1 - 0.046 13.5 0.4 0.078 12.7 0.4 1.3 1 0 0 1 1 1 0 Immunity protein 49 Citrate_bind PF16114.5 ORX49781.1 - 0.11 12.0 0.0 0.23 10.9 0.0 1.5 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding Methyltransf_25 PF13649.6 ORX49782.1 - 4.5e-17 62.5 0.0 1.4e-16 60.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX49782.1 - 6.5e-17 62.0 0.0 2.1e-16 60.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX49782.1 - 8.3e-14 51.6 0.0 2.5e-13 50.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX49782.1 - 1.1e-11 44.8 0.0 1.7e-11 44.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX49782.1 - 3.7e-11 42.8 0.0 1e-10 41.4 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX49782.1 - 1.6e-06 28.8 0.0 4.6e-06 27.3 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX49782.1 - 0.00013 21.5 0.0 0.0088 15.5 0.0 2.4 2 0 0 2 2 2 1 Putative methyltransferase CheR PF01739.18 ORX49782.1 - 0.0014 18.1 0.0 0.0042 16.6 0.0 1.7 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_2 PF00891.18 ORX49782.1 - 0.0035 16.6 0.1 0.0058 15.9 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain Methyltransf_8 PF05148.15 ORX49782.1 - 0.0058 16.5 0.0 0.012 15.5 0.0 1.5 1 1 0 1 1 1 1 Hypothetical methyltransferase FtsJ PF01728.19 ORX49782.1 - 0.0098 16.0 0.0 0.026 14.6 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase PCMT PF01135.19 ORX49782.1 - 0.011 15.5 0.0 0.036 13.8 0.0 1.8 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 ORX49782.1 - 0.013 14.8 0.1 0.062 12.6 0.0 2.2 2 1 0 2 2 2 0 Mycolic acid cyclopropane synthetase MTS PF05175.14 ORX49782.1 - 0.023 14.3 0.0 0.056 13.0 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.17 ORX49782.1 - 0.027 13.6 0.0 0.23 10.6 0.0 2.2 2 0 0 2 2 2 0 NNMT/PNMT/TEMT family Methyltransf_29 PF03141.16 ORX49782.1 - 0.1 11.1 0.0 0.16 10.5 0.0 1.3 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase TehB PF03848.14 ORX49782.1 - 0.16 11.4 0.1 0.72 9.2 0.1 2.0 1 1 0 1 1 1 0 Tellurite resistance protein TehB Skp1_POZ PF03931.15 ORX49783.1 - 1.6e-11 44.2 0.0 2.3e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 ORX49783.1 - 0.0067 16.6 0.0 0.01 16.1 0.0 1.4 1 1 0 1 1 1 1 BTB/POZ domain KilA-N PF04383.13 ORX49784.1 - 0.00013 21.8 0.7 0.00013 21.8 0.7 3.5 3 1 0 3 3 3 1 KilA-N domain UPF0242 PF06785.11 ORX49784.1 - 0.00072 19.7 11.6 0.04 14.0 6.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus Vps52 PF04129.12 ORX49784.1 - 0.0062 15.3 1.6 0.0062 15.3 1.6 1.4 2 0 0 2 2 2 1 Vps52 / Sac2 family PKcGMP_CC PF16808.5 ORX49784.1 - 0.035 14.0 1.9 4.2 7.3 0.3 3.0 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CSN5_C PF18323.1 ORX49784.1 - 0.15 13.0 0.1 0.15 13.0 0.1 2.9 2 1 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain Sec16 PF12932.7 ORX49784.1 - 0.44 11.2 2.7 0.4 11.3 0.2 2.1 2 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region kleA_kleC PF17383.2 ORX49784.1 - 0.47 10.8 7.8 1.5 9.2 1.1 2.5 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A DHR10 PF18595.1 ORX49784.1 - 0.47 10.5 22.7 0.042 13.9 5.9 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain YlbD_coat PF14071.6 ORX49784.1 - 0.49 10.7 10.1 0.39 11.0 4.8 2.5 2 0 0 2 2 2 0 Putative coat protein DUF4407 PF14362.6 ORX49784.1 - 0.55 9.5 8.7 0.95 8.8 8.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ACCA PF03255.14 ORX49784.1 - 0.68 9.8 7.9 6.3 6.7 1.2 2.4 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CRR7 PF12095.8 ORX49784.1 - 1.9 9.0 5.4 0.53 10.8 1.1 2.2 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 CENP-H PF05837.12 ORX49784.1 - 3.3 8.2 12.9 2.2 8.7 3.2 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF883 PF05957.13 ORX49784.1 - 4.1 8.1 11.4 11 6.7 1.6 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DAO PF01266.24 ORX49785.1 - 3.3e-54 184.8 0.0 4.1e-54 184.5 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ORX49785.1 - 7.2e-05 22.0 0.1 0.0021 17.2 0.0 2.4 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ORX49785.1 - 0.00014 22.0 0.3 0.00034 20.8 0.1 1.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX49785.1 - 0.00057 19.2 0.2 0.0014 18.0 0.0 1.7 2 0 0 2 2 2 1 Thi4 family Mqo PF06039.15 ORX49785.1 - 0.0052 15.4 0.1 1.7 7.1 0.0 2.1 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) FAD_binding_3 PF01494.19 ORX49785.1 - 0.0054 16.0 0.4 0.011 15.0 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX49785.1 - 0.0077 15.5 1.4 0.045 13.0 0.2 2.2 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX49785.1 - 0.025 13.6 0.1 0.052 12.6 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein MCRA PF06100.11 ORX49785.1 - 0.083 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 MCRA family Pyr_redox PF00070.27 ORX49785.1 - 0.33 11.5 1.8 19 5.9 0.1 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.22 ORX49786.1 - 1.6e-15 56.7 0.1 2.3e-15 56.2 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX49786.1 - 0.0025 17.4 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ORX49786.1 - 0.033 14.2 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif ER PF01133.17 ORX49786.1 - 0.043 13.8 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 Enhancer of rudimentary RRM_occluded PF16842.5 ORX49786.1 - 0.045 13.6 0.0 0.079 12.8 0.0 1.3 1 1 0 1 1 1 0 Occluded RNA-recognition motif His_Phos_2 PF00328.22 ORX49787.1 - 3.8e-21 75.9 0.0 1.8e-20 73.7 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) G-alpha PF00503.20 ORX49789.1 - 2.6e-116 388.7 3.3 2.9e-116 388.5 3.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX49789.1 - 5.3e-15 55.3 2.6 2.2e-10 40.3 0.4 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX49789.1 - 0.00041 19.8 0.4 0.12 11.7 0.2 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX49789.1 - 0.0015 18.8 0.3 1 9.6 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ORX49789.1 - 0.0029 17.0 0.1 0.0082 15.5 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_29 PF13555.6 ORX49789.1 - 0.04 13.7 0.0 0.079 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain KIND PF16474.5 ORX49789.1 - 0.076 12.9 0.0 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain MMR_HSR1 PF01926.23 ORX49789.1 - 0.1 12.7 0.1 2.9 8.0 0.1 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX49789.1 - 0.15 12.4 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Rad21_Rec8_N PF04825.13 ORX49790.1 - 1.8e-29 102.1 0.3 3.3e-29 101.3 0.3 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein DUF4709 PF15821.5 ORX49790.1 - 0.11 12.8 0.0 0.34 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) Acetyltransf_7 PF13508.7 ORX49791.1 - 1.5e-07 31.7 0.0 2.8e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX49791.1 - 4e-06 27.1 0.0 8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX49791.1 - 7.6e-06 25.9 0.0 1.7e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PHD PF00628.29 ORX49791.1 - 0.0036 17.1 12.7 0.0073 16.2 12.7 1.5 1 0 0 1 1 1 1 PHD-finger Forkhead PF00250.18 ORX49791.1 - 0.064 13.5 0.0 0.17 12.2 0.0 1.6 1 0 0 1 1 1 0 Forkhead domain Ferlin_C PF16165.5 ORX49791.1 - 0.093 12.7 3.3 0.18 11.8 3.3 1.4 1 0 0 1 1 1 0 Ferlin C-terminus FR47 PF08445.10 ORX49791.1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_9 PF13527.7 ORX49791.1 - 0.12 12.4 0.1 0.38 10.8 0.1 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Tli4_C PF18426.1 ORX49791.1 - 0.35 11.2 2.7 0.7 10.2 2.7 1.4 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain V-SNARE_C PF12352.8 ORX49792.1 - 2.3e-11 43.8 1.6 2.3e-11 43.8 1.6 2.3 4 0 0 4 4 4 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ORX49792.1 - 0.048 13.6 1.7 0.29 11.1 0.0 2.5 3 0 0 3 3 3 0 Sec20 AAA PF00004.29 ORX49793.1 - 6.4e-65 217.5 0.0 2e-44 151.2 0.0 3.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX49793.1 - 1.6e-10 41.6 3.9 0.0068 16.8 0.0 4.8 4 1 0 4 4 3 2 AAA ATPase domain AAA_lid_3 PF17862.1 ORX49793.1 - 3.1e-08 33.3 3.6 2.4e-05 24.0 0.1 2.9 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ORX49793.1 - 1.8e-06 27.8 0.0 0.0018 18.1 0.0 2.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 ORX49793.1 - 2.3e-05 24.7 0.0 0.26 11.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ORX49793.1 - 3.8e-05 24.3 0.0 0.013 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ORX49793.1 - 4.9e-05 23.3 0.0 0.056 13.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ORX49793.1 - 6.2e-05 22.6 0.0 0.098 12.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region RNA_helicase PF00910.22 ORX49793.1 - 7e-05 23.2 0.0 0.048 14.1 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 ORX49793.1 - 7.1e-05 22.8 0.1 0.015 15.3 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ORX49793.1 - 7.9e-05 22.0 0.0 0.013 14.7 0.0 2.4 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 ORX49793.1 - 8.4e-05 22.9 0.1 0.026 14.8 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX49793.1 - 0.00047 20.3 0.0 0.59 10.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ORX49793.1 - 0.0005 19.9 0.0 0.0044 16.8 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein ATPase_2 PF01637.18 ORX49793.1 - 0.00064 19.7 0.1 0.67 9.8 0.0 2.9 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ORX49793.1 - 0.00087 19.3 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ORX49793.1 - 0.00096 18.4 0.0 1.2 8.2 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Parvo_NS1 PF01057.17 ORX49793.1 - 0.0015 17.7 0.0 0.0025 17.0 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 ORX49793.1 - 0.0018 17.9 0.1 0.01 15.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 ORX49793.1 - 0.0035 16.7 0.0 0.0079 15.6 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_2 PF07724.14 ORX49793.1 - 0.0041 17.3 0.0 0.021 15.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 ORX49793.1 - 0.0041 16.8 0.0 0.67 9.6 0.0 3.1 3 0 0 3 3 3 1 Sigma-54 interaction domain NB-ARC PF00931.22 ORX49793.1 - 0.0052 16.0 0.0 3.3 6.8 0.0 2.8 3 0 0 3 3 3 1 NB-ARC domain Mg_chelatase PF01078.21 ORX49793.1 - 0.0055 16.1 0.1 0.029 13.8 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ORX49793.1 - 0.0083 16.1 0.2 1.1 9.1 0.1 3.5 4 0 0 4 4 3 1 NACHT domain Cytidylate_kin PF02224.18 ORX49793.1 - 0.0084 15.9 0.3 3 7.5 0.0 2.9 3 0 0 3 3 3 1 Cytidylate kinase AAA_24 PF13479.6 ORX49793.1 - 0.011 15.4 0.1 0.13 12.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ORX49793.1 - 0.013 15.4 0.0 1.4 8.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 ORX49793.1 - 0.027 14.3 0.0 0.46 10.3 0.0 3.0 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX49793.1 - 0.035 13.8 1.7 4.1 7.1 0.0 3.5 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 ORX49793.1 - 0.039 13.9 0.0 2.2 8.1 0.0 2.5 2 1 0 2 2 2 0 Rad17 P-loop domain Vps4_C PF09336.10 ORX49793.1 - 0.04 13.9 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain PhoH PF02562.16 ORX49793.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 ORX49793.1 - 0.1 13.1 0.0 2.7 8.5 0.0 2.6 2 0 0 2 2 2 0 ABC transporter AAA_6 PF12774.7 ORX49793.1 - 0.15 11.0 0.1 18 4.2 0.0 2.9 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region AAA_29 PF13555.6 ORX49793.1 - 0.23 11.2 0.5 27 4.6 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Methyltransf_22 PF13383.6 ORX49794.1 - 6.8e-14 52.0 1.7 4.4e-07 29.7 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_21 PF05050.12 ORX49794.1 - 7.3e-05 22.8 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase FkbM domain Mu-like_gpT PF10124.9 ORX49795.1 - 0.052 12.9 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Mu-like prophage major head subunit gpT Aminotran_1_2 PF00155.21 ORX49796.1 - 2.7e-45 155.1 0.0 3.3e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MOR2-PAG1_C PF14225.6 ORX49796.1 - 0.012 15.5 0.1 2.4 8.0 0.0 2.3 2 0 0 2 2 2 0 Cell morphogenesis C-terminal Cys_Met_Meta_PP PF01053.20 ORX49796.1 - 0.11 11.1 0.0 0.15 10.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme CAF1A PF12253.8 ORX49797.1 - 1.5 9.0 10.2 3 8.1 9.9 1.7 1 1 0 1 1 1 0 Chromatin assembly factor 1 subunit A Pkinase PF00069.25 ORX49798.1 - 3.2e-72 243.1 0.0 4.3e-72 242.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49798.1 - 1.2e-33 116.5 0.0 1.7e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX49798.1 - 3.4e-12 46.9 3.6 3.4e-12 46.9 3.6 2.0 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 ORX49798.1 - 2.8e-07 29.8 0.0 4e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX49798.1 - 0.0042 16.4 0.0 0.038 13.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Imm7 PF15585.6 ORX49798.1 - 0.01 16.1 0.0 0.019 15.3 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 7 APH PF01636.23 ORX49798.1 - 0.084 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX49798.1 - 0.11 11.9 0.1 0.22 10.9 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PDEase_I PF00233.19 ORX49799.1 - 3.1e-73 246.4 0.4 4.7e-73 245.8 0.4 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 ORX49799.1 - 0.00015 21.9 0.0 0.00035 20.7 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain V-ATPase_H_N PF03224.14 ORX49800.1 - 2.7e-69 233.9 7.4 2.7e-69 233.9 7.4 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 ORX49800.1 - 5.6e-38 129.7 4.1 1.3e-37 128.5 0.3 2.6 2 0 0 2 2 2 1 V-ATPase subunit H HEAT_2 PF13646.6 ORX49800.1 - 0.0012 19.2 0.0 0.0056 17.0 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats Adaptin_N PF01602.20 ORX49800.1 - 0.0028 16.3 2.2 0.015 13.9 2.3 2.3 1 1 0 1 1 1 1 Adaptin N terminal region Astro_capsid_p PF12226.8 ORX49800.1 - 0.027 13.7 0.1 0.046 12.9 0.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CDC45 PF02724.14 ORX49801.1 - 0.49 8.6 6.3 0.57 8.4 6.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L22e PF01776.17 ORX49803.1 - 1.1e-48 164.1 3.0 1.3e-48 163.9 3.0 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family DLIC PF05783.11 ORX49804.1 - 1.6e-51 175.6 1.7 5.1e-44 150.9 0.1 2.2 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) Thymidylate_kin PF02223.17 ORX49805.1 - 1.5e-48 164.9 0.0 1.7e-48 164.8 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 ORX49805.1 - 0.00036 21.1 0.1 0.00094 19.7 0.0 1.8 1 1 1 2 2 2 1 AAA domain KTI12 PF08433.10 ORX49805.1 - 0.00038 20.0 0.0 0.00082 18.9 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_22 PF13401.6 ORX49805.1 - 0.00096 19.4 0.1 0.0018 18.6 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX49805.1 - 0.0019 18.7 2.0 0.099 13.1 0.1 2.8 1 1 1 2 2 2 1 AAA domain MobB PF03205.14 ORX49805.1 - 0.0033 17.3 0.3 0.0093 15.9 0.1 1.8 2 1 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.6 ORX49805.1 - 0.0034 17.7 0.2 0.0071 16.6 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX49805.1 - 0.01 16.0 0.2 0.019 15.2 0.0 1.5 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 ORX49805.1 - 0.013 15.2 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 ORX49805.1 - 0.028 14.5 0.0 0.057 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain DnaB_C PF03796.15 ORX49805.1 - 0.059 12.7 0.0 0.066 12.5 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain DNA_pol_delta_4 PF04081.13 ORX49805.1 - 0.074 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 RNA_helicase PF00910.22 ORX49805.1 - 0.086 13.2 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 RNA helicase ADK PF00406.22 ORX49805.1 - 0.097 12.8 0.1 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 Adenylate kinase GST_C_3 PF14497.6 ORX49806.1 - 2.4e-09 37.3 0.0 3.9e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX49806.1 - 7e-09 36.0 0.1 4.8e-08 33.3 0.0 2.2 2 1 1 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX49806.1 - 1.9e-07 31.3 0.1 6.8e-07 29.5 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX49806.1 - 2e-06 27.7 0.1 3.6e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX49806.1 - 6.1e-06 26.4 0.0 9.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX49806.1 - 1.5e-05 25.2 0.0 2.9e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 ORX49806.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_N_4 PF17172.4 ORX49806.1 - 0.13 13.0 0.0 0.49 11.2 0.0 1.9 1 1 1 2 2 2 0 Glutathione S-transferase N-terminal domain DnaJ_C PF01556.18 ORX49807.1 - 3.7e-21 75.8 0.0 6e-21 75.1 0.0 1.3 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX49807.1 - 3.1e-20 72.1 2.3 7.3e-20 70.9 2.3 1.6 1 1 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX49807.1 - 1.7e-10 41.1 18.9 1.7e-10 41.1 18.9 2.1 1 1 1 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 ORX49807.1 - 0.23 11.4 15.8 2.7 8.0 2.7 3.9 1 1 4 5 5 5 0 Tryptophan RNA-binding attenuator protein inhibitory protein PHD PF00628.29 ORX49808.1 - 3.4e-05 23.7 7.2 3.4e-05 23.7 7.2 3.2 3 0 0 3 3 3 2 PHD-finger DUF3580 PF12117.8 ORX49808.1 - 0.03 14.6 0.2 0.055 13.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) C1_1 PF00130.22 ORX49808.1 - 0.031 14.2 1.2 0.031 14.2 1.2 4.0 4 1 1 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ysc84 PF04366.12 ORX49811.1 - 4.5e-34 117.0 1.2 8.1e-34 116.1 1.2 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ORX49811.1 - 5.9e-10 38.6 0.1 1.1e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX49811.1 - 1e-09 38.1 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX49811.1 - 1.8e-05 24.3 0.0 3.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF3104 PF11302.8 ORX49811.1 - 0.14 11.9 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) DUF3318 PF11780.8 ORX49813.1 - 0.021 14.8 1.9 0.34 10.8 1.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3318) HIT PF01230.23 ORX49814.1 - 2.8e-24 85.7 0.2 3.5e-24 85.4 0.2 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX49814.1 - 1e-11 45.3 0.2 1.4e-11 44.9 0.2 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX49814.1 - 2.2e-05 24.3 0.6 3.7e-05 23.6 0.6 1.4 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 eIF-5_eIF-2B PF01873.17 ORX49815.1 - 4.5e-41 139.4 0.0 8.2e-41 138.6 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 ORX49815.1 - 1.4e-20 73.2 0.8 1.4e-20 73.2 0.8 2.7 2 1 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Chitin_synth_2 PF03142.15 ORX49816.1 - 1.4e-234 779.6 1.1 2.2e-234 779.0 1.1 1.3 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX49816.1 - 9.4e-107 357.9 0.0 1.5e-106 357.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ORX49816.1 - 3.2e-19 68.8 0.6 2.5e-13 50.0 0.0 3.5 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 ORX49816.1 - 3.2e-17 62.2 0.4 8.2e-17 60.9 0.4 1.8 1 0 0 1 1 1 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX49816.1 - 1e-11 45.2 0.0 4.2e-11 43.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX49816.1 - 1.3e-10 41.6 1.9 1.3e-10 41.6 1.9 2.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX49816.1 - 0.0062 16.4 0.0 0.093 12.5 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX49816.1 - 0.024 14.1 0.3 0.12 11.9 0.0 2.2 3 0 0 3 3 3 0 Glycosyl transferase family 21 AAA_29 PF13555.6 ORX49816.1 - 0.049 13.4 0.0 0.2 11.4 0.0 2.1 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX49816.1 - 0.052 13.9 0.0 0.052 13.9 0.0 2.5 3 0 0 3 3 3 0 AAA ATPase domain APS_kinase PF01583.20 ORX49816.1 - 0.13 12.1 0.1 0.49 10.3 0.0 1.9 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_22 PF13401.6 ORX49816.1 - 0.15 12.4 0.3 1.2 9.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ORX49816.1 - 0.17 11.8 0.0 0.39 10.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TMEM171 PF15471.6 ORX49816.1 - 0.68 8.9 4.1 0.67 8.9 1.5 2.1 2 0 0 2 2 2 0 Transmembrane protein family 171 Zip PF02535.22 ORX49817.1 - 7.6e-61 206.2 10.2 2.7e-60 204.4 10.2 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter COX7C PF02935.16 ORX49817.1 - 3 8.2 7.5 0.25 11.7 1.2 2.5 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIIc SWIB PF02201.18 ORX49818.1 - 6.9e-30 102.8 0.1 1.2e-29 102.0 0.1 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain DEK_C PF08766.11 ORX49818.1 - 2.2e-12 46.7 0.1 7.5e-12 45.0 0.0 1.8 2 0 0 2 2 2 1 DEK C terminal domain Bile_Hydr_Trans PF04775.14 ORX49819.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA thioester hydrolase/BAAT N-terminal region DnaJ PF00226.31 ORX49820.1 - 8.6e-19 67.4 0.9 7.4e-18 64.4 0.6 2.5 2 0 0 2 2 2 1 DnaJ domain LPD30 PF18850.1 ORX49820.1 - 0.19 11.5 6.6 0.52 10.1 6.6 1.8 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 MRP-S26 PF14943.6 ORX49820.1 - 2 8.3 26.5 0.12 12.3 20.7 1.9 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 DUF572 PF04502.13 ORX49820.1 - 9.6 5.7 24.3 14 5.2 24.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ribosomal_L16 PF00252.18 ORX49822.1 - 8.7e-45 152.0 0.0 1.1e-44 151.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e ATG16 PF08614.11 ORX49823.1 - 5.9e-06 26.7 14.3 5.9e-06 26.7 14.3 2.3 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Fib_alpha PF08702.10 ORX49823.1 - 7.9e-05 22.9 10.9 0.0022 18.2 4.3 3.0 2 1 0 2 2 2 2 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ORX49823.1 - 0.01 16.4 9.6 0.01 16.4 9.6 3.4 3 1 0 4 4 3 0 Apg6 coiled-coil region DUF3450 PF11932.8 ORX49823.1 - 0.016 14.5 18.7 0.24 10.7 9.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Rootletin PF15035.6 ORX49823.1 - 0.018 15.1 12.3 0.015 15.3 10.4 1.8 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion GOLGA2L5 PF15070.6 ORX49823.1 - 0.14 10.8 14.5 0.023 13.4 6.8 2.3 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 PspA_IM30 PF04012.12 ORX49823.1 - 0.15 11.6 9.3 0.39 10.3 9.0 1.9 1 1 0 1 1 1 0 PspA/IM30 family Myosin_tail_1 PF01576.19 ORX49823.1 - 0.16 9.7 11.8 0.2 9.4 6.5 2.1 2 0 0 2 2 2 0 Myosin tail Fusion_gly PF00523.18 ORX49823.1 - 0.16 10.1 0.7 0.27 9.4 0.7 1.2 1 0 0 1 1 1 0 Fusion glycoprotein F0 Wtap PF17098.5 ORX49823.1 - 0.34 10.8 13.8 7.1 6.5 5.9 3.3 2 1 1 3 3 3 0 WTAP/Mum2p family ApoLp-III PF07464.11 ORX49823.1 - 0.37 10.9 11.1 0.069 13.2 6.5 2.1 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) DUF641 PF04859.12 ORX49823.1 - 0.56 10.5 8.7 0.22 11.8 1.2 2.9 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DMPK_coil PF08826.10 ORX49823.1 - 0.56 10.3 12.5 1.7 8.8 1.5 3.7 3 0 0 3 3 3 0 DMPK coiled coil domain like DUF4407 PF14362.6 ORX49823.1 - 0.8 9.0 8.8 5.2 6.3 8.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MerR-DNA-bind PF09278.11 ORX49823.1 - 1.5 9.4 7.4 0.53 10.9 0.8 3.3 2 1 1 3 3 3 0 MerR, DNA binding Spc7 PF08317.11 ORX49823.1 - 1.6 7.5 13.5 0.093 11.6 5.7 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein THOC7 PF05615.13 ORX49823.1 - 2.1 8.6 10.7 1.4 9.2 7.6 2.3 2 1 1 3 3 3 0 Tho complex subunit 7 Muted PF14942.6 ORX49823.1 - 2.3 8.5 10.2 1.3 9.4 4.8 2.5 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Tropomyosin_1 PF12718.7 ORX49823.1 - 2.7 8.1 17.9 0.049 13.8 6.1 3.0 3 0 0 3 3 3 0 Tropomyosin like Prefoldin PF02996.17 ORX49823.1 - 3 7.8 9.2 3.2 7.7 3.2 2.6 1 1 1 2 2 2 0 Prefoldin subunit Filament PF00038.21 ORX49823.1 - 3.5 7.1 16.3 0.064 12.8 8.4 2.0 2 0 0 2 2 2 0 Intermediate filament protein DUF724 PF05266.14 ORX49823.1 - 3.9 7.3 13.1 0.84 9.4 3.6 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Phage_GP20 PF06810.11 ORX49823.1 - 3.9 7.3 10.6 2.3 8.0 7.1 2.3 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF948 PF06103.11 ORX49823.1 - 5.9 7.2 5.5 1.9 8.8 1.7 2.1 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) DUF16 PF01519.16 ORX49823.1 - 8.8 6.9 13.4 40 4.8 0.1 3.0 3 0 0 3 3 2 0 Protein of unknown function DUF16 CSN5_C PF18323.1 ORX49823.1 - 9.2 7.3 10.1 5.1 8.1 4.5 2.7 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain S10_plectin PF03501.15 ORX49824.1 - 1.8e-44 149.7 0.0 2.1e-44 149.5 0.0 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 ORX49824.1 - 0.021 14.6 0.0 0.032 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TrmB PF01978.19 ORX49824.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.5 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB Fungal_trans PF04082.18 ORX49825.1 - 8.8e-39 133.1 0.1 2.1e-38 131.9 0.1 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX49825.1 - 2.5e-09 37.1 10.0 4.5e-09 36.3 10.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rnk_N PF14760.6 ORX49825.1 - 0.18 12.3 0.3 0.54 10.8 0.3 1.9 1 0 0 1 1 1 0 Rnk N-terminus Ribosomal_L13e PF01294.18 ORX49826.1 - 9.2e-81 270.0 5.0 1.3e-80 269.5 5.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e CitMHS PF03600.16 ORX49827.1 - 9.4e-17 61.1 33.3 1.5e-15 57.2 28.4 3.3 1 1 1 2 2 2 2 Citrate transporter ArsB PF02040.15 ORX49827.1 - 9.1e-14 51.6 20.7 2.3e-07 30.5 11.2 2.4 2 1 0 2 2 2 2 Arsenical pump membrane protein DUF1752 PF08550.10 ORX49828.1 - 2.2e-08 33.8 2.4 3.6e-08 33.1 1.1 2.0 3 0 0 3 3 3 1 Fungal protein of unknown function (DUF1752) DUF3403 PF11883.8 ORX49828.1 - 0.02 15.0 2.1 0.76 9.9 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3403) Mpv17_PMP22 PF04117.12 ORX49829.1 - 2e-24 85.6 0.8 4.9e-24 84.3 0.8 1.7 1 0 0 1 1 1 1 Mpv17 / PMP22 family AdoHcyase PF05221.17 ORX49831.1 - 7.5e-136 452.1 0.0 3.6e-74 249.6 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ORX49831.1 - 2.5e-85 284.5 2.1 4e-85 283.8 2.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 ORX49831.1 - 3.9e-09 36.1 0.1 7.7e-09 35.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ORX49831.1 - 9.5e-06 25.3 0.2 1.6e-05 24.5 0.2 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ORX49831.1 - 0.02 15.1 0.1 0.047 14.0 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Kei1 PF08552.11 ORX49832.1 - 6.3e-10 39.2 12.2 7.3e-07 29.2 0.9 2.0 1 1 1 2 2 2 2 Inositolphosphorylceramide synthase subunit Kei1 zf-C2H2 PF00096.26 ORX49833.1 - 2.7e-08 33.8 11.3 5.2e-05 23.5 1.7 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX49833.1 - 1.6e-07 31.4 9.8 1.2e-06 28.7 2.0 3.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX49833.1 - 0.0012 19.5 6.3 0.51 11.3 1.1 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX49833.1 - 0.074 13.7 0.9 0.56 10.9 0.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX49833.1 - 0.15 12.1 1.2 0.42 10.7 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Ribosomal_S13 PF00416.22 ORX49837.1 - 1.6e-54 183.7 2.7 1.9e-54 183.5 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX49837.1 - 0.0078 15.0 0.0 0.0078 15.0 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Rubella_Capsid PF05750.11 ORX49838.1 - 0.038 13.6 9.2 0.046 13.3 9.2 1.0 1 0 0 1 1 1 0 Rubella capsid protein eIF-3_zeta PF05091.12 ORX49838.1 - 0.063 12.2 11.9 0.071 12.1 11.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RRN3 PF05327.11 ORX49838.1 - 0.088 11.3 7.6 0.1 11.1 7.6 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM60A PF15396.6 ORX49838.1 - 0.53 10.3 13.7 0.73 9.8 13.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 ORX49838.1 - 0.66 8.2 19.6 0.66 8.2 19.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Med19 PF10278.9 ORX49838.1 - 1.8 8.4 21.8 2.9 7.8 21.8 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 NARP1 PF12569.8 ORX49838.1 - 3.9 6.3 15.4 3.9 6.3 15.4 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 ORX49838.1 - 6 5.5 13.4 6.7 5.4 13.4 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ORX49838.1 - 7 6.4 14.3 8.2 6.2 14.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ORX49838.1 - 9.4 5.3 8.0 9.7 5.3 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PXA PF02194.15 ORX49839.1 - 1.5e-21 77.2 0.1 4.4e-21 75.7 0.1 1.9 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 ORX49839.1 - 5.2e-19 68.9 1.2 2.1e-18 66.9 1.2 2.1 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 ORX49839.1 - 5.1e-06 26.5 0.0 1.4e-05 25.0 0.0 1.8 1 0 0 1 1 1 1 PX domain Kinesin PF00225.23 ORX49840.1 - 3.2e-76 256.4 0.1 8.5e-76 255.0 0.1 1.8 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX49840.1 - 0.0014 18.6 0.0 0.0052 16.7 0.0 2.1 1 0 0 1 1 1 1 Microtubule binding DUF58 PF01882.18 ORX49842.1 - 0.63 10.4 6.1 3.4 8.0 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function DUF58 DUF58 PF01882.18 ORX49844.1 - 0.22 11.8 4.4 64 3.9 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function DUF58 Coiled-coil_56 PF09813.9 ORX49845.1 - 0.0011 18.9 0.3 0.0025 17.8 0.0 1.6 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 56 Nup54 PF13874.6 ORX49847.1 - 2.8e-33 115.0 5.2 4e-33 114.5 5.2 1.2 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 Nup88 PF10168.9 ORX49847.1 - 0.0061 14.4 6.1 0.0075 14.2 6.1 1.1 1 0 0 1 1 1 1 Nuclear pore component MnmE_helical PF12631.7 ORX49847.1 - 0.032 14.4 0.1 0.038 14.1 0.1 1.2 1 0 0 1 1 1 0 MnmE helical domain DUF2408 PF10303.9 ORX49847.1 - 0.037 14.6 2.9 0.061 13.9 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) RPA_interact_M PF14767.6 ORX49847.1 - 0.4 11.3 3.2 0.28 11.8 1.1 1.9 2 0 0 2 2 2 0 Replication protein A interacting middle IF4E PF01652.18 ORX49848.1 - 2e-54 183.7 1.3 2.3e-54 183.5 1.3 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ras PF00071.22 ORX49850.1 - 1.3e-59 200.4 0.1 1.5e-59 200.2 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX49850.1 - 6.5e-22 78.0 0.0 9.2e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX49850.1 - 1.3e-07 31.3 0.0 1.4e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX49850.1 - 0.00018 21.4 0.0 0.23 11.4 0.0 2.2 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX49850.1 - 0.0006 19.4 0.0 0.0013 18.3 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX49850.1 - 0.0055 16.8 0.0 0.0086 16.2 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX49850.1 - 0.0063 16.0 0.0 0.028 14.0 0.0 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B BING4CT PF08149.11 ORX49851.1 - 9.5e-41 137.5 0.0 1.4e-38 130.5 0.0 3.4 3 0 0 3 3 3 1 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 ORX49851.1 - 9.4e-09 35.5 0.0 0.86 9.9 0.0 4.6 1 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX49851.1 - 2.5e-08 34.4 0.1 0.00019 22.2 0.0 3.9 6 0 0 6 6 6 2 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 ORX49851.1 - 2e-06 27.1 0.0 3.1e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Coatomer WD associated region MMS1_N PF10433.9 ORX49851.1 - 0.12 10.9 0.0 0.25 9.9 0.0 1.4 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Cyto_heme_lyase PF01265.17 ORX49852.1 - 1.1e-54 186.0 10.8 5.1e-54 183.8 10.8 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase BsuPI PF12690.7 ORX49852.1 - 0.091 12.8 1.0 0.12 12.5 0.1 1.6 2 0 0 2 2 2 0 Intracellular proteinase inhibitor Cation_efflux PF01545.21 ORX49853.1 - 1.4e-05 24.9 11.0 7.8e-05 22.5 11.0 2.0 1 1 0 1 1 1 1 Cation efflux family 7tm_3 PF00003.22 ORX49853.1 - 0.00085 19.1 3.1 0.00085 19.1 3.1 2.3 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Flavi_NS4A PF01350.17 ORX49853.1 - 0.29 11.1 2.1 0.29 11.1 0.3 1.9 2 0 0 2 2 2 0 Flavivirus non-structural protein NS4A CRCB PF02537.15 ORX49853.1 - 0.35 11.2 4.4 0.13 12.6 0.6 2.1 2 2 0 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) DUF3784 PF12650.7 ORX49853.1 - 4 7.7 12.9 1 9.6 0.6 3.5 3 1 1 4 4 4 0 Domain of unknown function (DUF3784) TetR_C_37 PF18665.1 ORX49854.1 - 0.11 13.1 0.1 0.2 12.2 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF5595 PF18077.1 ORX49854.1 - 0.17 12.0 3.8 0.3 11.2 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) IZUMO PF15005.6 ORX49854.1 - 0.22 12.0 4.9 5.8 7.4 0.1 2.2 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Actin PF00022.19 ORX49855.1 - 4e-83 279.3 0.0 1.1e-81 274.5 0.0 2.0 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ORX49855.1 - 1.9e-05 23.6 0.0 0.11 11.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 ORX49855.1 - 0.0055 17.1 0.0 0.02 15.3 0.0 2.1 2 1 0 2 2 2 1 Cell division protein FtsA CTP_transf_like PF01467.26 ORX49856.1 - 7.2e-30 104.1 0.0 9e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Aminotran_1_2 PF00155.21 ORX49857.1 - 9.8e-61 205.9 0.0 1.2e-60 205.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX49857.1 - 0.0059 15.9 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 ORX49857.1 - 0.012 14.4 0.0 0.025 13.4 0.0 1.4 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, major domain Aminotran_5 PF00266.19 ORX49857.1 - 0.018 14.0 0.0 0.027 13.4 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ORX49857.1 - 0.075 11.6 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ecl1 PF12855.7 ORX49858.1 - 9.4e-05 23.6 21.2 0.00011 23.4 21.2 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins PLATZ PF04640.14 ORX49858.1 - 0.014 16.0 1.3 0.034 14.8 1.3 1.7 1 0 0 1 1 1 0 PLATZ transcription factor SCAI PF12070.8 ORX49859.1 - 5e-176 586.7 0.0 3.1e-129 432.3 0.0 2.1 2 0 0 2 2 2 2 Protein SCAI Peptidase_M36 PF02128.15 ORX49860.1 - 4.9e-151 503.1 11.2 6.6e-151 502.7 11.2 1.2 1 0 0 1 1 1 1 Fungalysin metallopeptidase (M36) FTP PF07504.13 ORX49860.1 - 1.3e-12 47.3 0.1 3.1e-12 46.1 0.1 1.7 1 0 0 1 1 1 1 Fungalysin/Thermolysin Propeptide Motif TBCC PF07986.12 ORX49861.1 - 1.2e-26 92.8 0.3 2e-26 92.1 0.3 1.4 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 ORX49861.1 - 7.6e-12 45.7 3.8 1.3e-11 45.0 3.8 1.3 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain IDO PF01231.18 ORX49862.1 - 2.5e-46 158.4 0.0 3e-46 158.1 0.0 1.1 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase CAMSAP_CH PF11971.8 ORX49862.1 - 0.19 11.6 0.3 0.9 9.4 0.0 2.2 2 0 0 2 2 2 0 CAMSAP CH domain Sel1 PF08238.12 ORX49863.1 - 1.8e-77 254.0 82.5 1.1e-07 32.3 0.0 25.7 28 0 0 28 28 28 19 Sel1 repeat TPR_16 PF13432.6 ORX49863.1 - 0.0043 17.7 0.6 0.0043 17.7 0.6 12.7 12 1 1 13 13 13 2 Tetratricopeptide repeat RIC1 PF07064.13 ORX49863.1 - 0.015 14.7 1.1 3.5 7.0 0.0 4.2 4 1 0 4 4 4 0 RIC1 PPO1_DWL PF12142.8 ORX49863.1 - 0.093 12.5 0.3 2.8 7.8 0.0 2.7 2 0 0 2 2 2 0 Polyphenol oxidase middle domain TPR_17 PF13431.6 ORX49863.1 - 0.12 12.8 11.6 1e+02 3.6 0.0 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX49863.1 - 2.2 8.2 52.0 2.3 8.2 0.0 13.7 15 0 0 15 15 15 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX49863.1 - 6.5 6.8 28.8 0.81 9.6 0.1 9.8 11 0 0 11 11 11 0 Tetratricopeptide repeat 2-Hacid_dh_C PF02826.19 ORX49864.1 - 2.5e-51 173.6 0.0 5.3e-51 172.5 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX49864.1 - 4.4e-36 123.5 0.1 6.2e-36 123.0 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ORX49864.1 - 0.0022 18.2 1.2 0.0075 16.4 0.2 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 ORX49864.1 - 0.0049 16.9 0.5 0.045 13.8 0.1 2.2 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 ORX49864.1 - 0.043 13.6 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 ACT domain DUF4750 PF15938.5 ORX49866.1 - 0.055 13.1 1.9 0.28 10.9 2.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4750) PilN_bio_d PF18222.1 ORX49866.1 - 0.14 12.6 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 PilN biogenesis protein dimerization domain ATP-sulfurylase PF01747.17 ORX49867.1 - 8.1e-88 293.4 0.1 1.2e-87 292.9 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 ORX49867.1 - 1.3e-53 180.9 0.0 2e-53 180.3 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain APS_kinase PF01583.20 ORX49867.1 - 1.3e-50 171.4 0.0 2.5e-50 170.5 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 ORX49867.1 - 0.0018 18.8 0.0 0.006 17.1 0.0 1.8 1 1 0 1 1 1 1 AAA domain Podoplanin PF05808.11 ORX49869.1 - 0.002 18.2 1.8 0.0035 17.5 1.8 1.4 1 0 0 1 1 1 1 Podoplanin Yip1 PF04893.17 ORX49869.1 - 0.032 13.9 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 Yip1 domain Phage_holin_2_4 PF16082.5 ORX49869.1 - 0.12 12.1 0.0 0.36 10.6 0.0 1.8 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Ndc1_Nup PF09531.10 ORX49869.1 - 4.2 6.0 4.8 5.1 5.7 4.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AdoMet_MTase PF07757.13 ORX49870.1 - 2.6e-37 127.6 0.0 4e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_32 PF13679.6 ORX49870.1 - 0.0086 16.1 0.9 0.05 13.6 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX49870.1 - 0.014 15.2 0.0 0.042 13.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 ORX49870.1 - 0.016 15.8 0.0 0.038 14.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ORX49870.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 ORX49870.1 - 0.03 13.9 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW AntA PF08346.12 ORX49870.1 - 0.034 14.7 0.1 0.11 13.1 0.0 1.9 2 0 0 2 2 2 0 AntA/AntB antirepressor Methyltransf_25 PF13649.6 ORX49870.1 - 0.075 13.7 0.0 0.16 12.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PAD PF03068.15 ORX49870.1 - 0.1 11.6 0.0 0.2 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) MTS PF05175.14 ORX49870.1 - 0.16 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NUP50 PF08911.11 ORX49871.1 - 5.2e-07 30.2 2.2 1.6e-06 28.7 2.2 2.0 1 1 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) YL1 PF05764.13 ORX49871.1 - 0.024 14.8 4.4 0.035 14.2 4.4 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CAF1A PF12253.8 ORX49871.1 - 0.12 12.6 6.6 0.18 12.0 6.6 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Arteri_Gl PF00951.18 ORX49871.1 - 0.14 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein NOA36 PF06524.12 ORX49871.1 - 8.6 5.6 7.2 12 5.1 7.2 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ORX49871.1 - 9.5 6.7 11.4 18 5.8 11.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NUDIX PF00293.28 ORX49873.1 - 2.9e-11 43.5 0.0 3.7e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Asn_synthase PF00733.21 ORX49874.1 - 5.6e-20 72.3 0.2 2.2e-16 60.5 0.2 2.9 1 1 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 ORX49874.1 - 2.8e-08 33.7 0.0 2.2e-07 30.8 0.0 2.2 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ORX49874.1 - 0.0016 18.6 0.0 0.0057 16.9 0.0 1.9 1 1 0 1 1 1 1 Glutamine amidotransferase domain DNA_pol_B PF00136.21 ORX49875.1 - 1e-121 406.9 0.0 3.5e-121 405.1 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX49875.1 - 6.1e-46 157.1 0.0 1.3e-45 156.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 ORX49875.1 - 5.1e-36 124.1 7.2 1.4e-35 122.7 7.2 1.8 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_alpha_N PF12254.8 ORX49875.1 - 1.8e-08 34.3 11.0 6.8e-08 32.5 11.0 2.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 ORX49875.1 - 0.0025 16.8 0.0 0.0051 15.7 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase type B, organellar and viral YL1 PF05764.13 ORX49875.1 - 0.0088 16.2 11.8 0.02 15.0 11.8 1.6 1 0 0 1 1 1 1 YL1 nuclear protein DUF1744 PF08490.12 ORX49875.1 - 0.14 10.7 3.0 0.53 8.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1744) zf-CHY PF05495.12 ORX49875.1 - 0.47 11.0 2.8 1.2 9.7 2.8 1.6 1 0 0 1 1 1 0 CHY zinc finger DUF4451 PF14616.6 ORX49876.1 - 9e-21 74.3 4.2 1e-20 74.1 4.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) zf-A20 PF01754.16 ORX49876.1 - 1.3 9.0 6.4 10 6.2 1.0 2.3 2 0 0 2 2 2 0 A20-like zinc finger WD40 PF00400.32 ORX49877.1 - 4.6e-37 125.4 27.3 2.6e-06 28.1 0.1 7.6 7 1 0 7 7 7 7 WD domain, G-beta repeat F-box PF00646.33 ORX49877.1 - 3.3e-08 33.2 1.3 9.7e-08 31.7 1.3 1.9 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ORX49877.1 - 7e-08 32.7 3.0 1.4 9.3 0.1 5.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ORX49877.1 - 2.2e-07 30.7 1.6 5e-07 29.5 1.6 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ORX49877.1 - 1.2e-06 27.5 9.5 0.039 12.6 0.1 5.3 3 3 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX49877.1 - 0.0002 20.8 0.3 0.061 12.7 0.1 2.7 1 1 2 3 3 3 3 WD40-like domain PQQ_2 PF13360.6 ORX49877.1 - 0.0037 16.9 0.3 0.19 11.3 0.1 2.7 1 1 1 2 2 2 2 PQQ-like domain BBS2_Mid PF14783.6 ORX49877.1 - 0.023 14.7 0.2 1.5 8.9 0.0 3.5 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 ORX49877.1 - 0.032 12.8 0.1 0.33 9.4 0.1 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain F-box_4 PF15966.5 ORX49877.1 - 0.07 13.0 0.2 0.18 11.7 0.2 1.7 1 0 0 1 1 1 0 F-box zf-RING_2 PF13639.6 ORX49879.1 - 3.5e-10 40.0 14.4 3.5e-10 40.0 14.4 2.2 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ORX49879.1 - 3.4e-07 30.4 10.2 7.9e-07 29.3 10.2 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ORX49879.1 - 5.1e-05 23.0 14.3 5.1e-05 23.0 14.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX49879.1 - 0.00018 21.2 10.9 0.00018 21.2 10.9 2.1 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX49879.1 - 0.00056 19.9 11.9 0.00066 19.6 7.5 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX49879.1 - 0.0014 18.5 14.8 0.0014 18.5 14.8 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX49879.1 - 0.0053 16.7 12.9 0.0053 16.7 12.9 1.8 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX49879.1 - 0.011 15.8 8.0 0.032 14.3 8.0 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ORX49879.1 - 0.05 13.8 12.7 0.17 12.1 12.7 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ORX49879.1 - 0.27 11.4 14.4 0.53 10.5 14.4 1.5 1 0 0 1 1 1 0 RING-variant domain Prok-RING_4 PF14447.6 ORX49879.1 - 0.59 10.0 10.8 1.6 8.6 10.8 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX49879.1 - 1.8 8.5 17.0 0.14 12.0 10.9 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 ORX49879.1 - 2.3 8.2 14.0 5.2 7.0 14.0 1.6 1 0 0 1 1 1 0 PHD-finger Pkinase PF00069.25 ORX49880.1 - 2.4e-61 207.4 0.0 3.1e-61 207.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49880.1 - 2.3e-31 109.0 0.0 2.7e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX49880.1 - 9.2e-07 28.5 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX49880.1 - 5.5e-05 22.6 1.4 8.7e-05 22.0 1.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ORX49880.1 - 0.0018 17.3 0.3 0.0027 16.7 0.3 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 ORX49880.1 - 0.005 16.8 1.1 0.011 15.7 1.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX49880.1 - 0.0083 15.1 0.7 0.012 14.5 0.7 1.2 1 0 0 1 1 1 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 ORX49880.1 - 0.014 15.0 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ORX49880.1 - 0.026 13.3 0.1 0.036 12.8 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase RIO1 PF01163.22 ORX49880.1 - 0.14 11.7 0.6 0.24 11.0 0.6 1.3 1 0 0 1 1 1 0 RIO1 family GST_N_3 PF13417.6 ORX49881.1 - 8.1e-14 51.8 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX49881.1 - 6.7e-11 42.4 0.0 1.2e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX49881.1 - 3.2e-10 40.2 0.0 5.2e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ORX49881.1 - 1.3e-07 32.1 0.0 2e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX49881.1 - 2.7e-06 27.3 0.1 4.5e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX49881.1 - 1.4e-05 25.2 0.0 2.7e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX49881.1 - 0.00023 21.3 0.0 0.00041 20.5 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 ORX49881.1 - 0.0067 16.6 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin GST_N_3 PF13417.6 ORX49882.1 - 8.4e-14 51.8 0.0 1.4e-13 51.0 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX49882.1 - 1.1e-11 44.9 0.1 4.6e-11 42.9 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX49882.1 - 5.8e-11 42.5 0.0 1e-10 41.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX49882.1 - 3.3e-07 30.2 0.1 6.8e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ORX49882.1 - 4.1e-07 30.5 0.0 6.6e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX49882.1 - 2.2e-06 27.8 0.0 3.7e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX49882.1 - 3.2e-06 27.2 0.0 5.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin PF00462.24 ORX49882.1 - 0.0018 18.5 0.0 0.0036 17.5 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin SUR7 PF06687.12 ORX49883.1 - 4.5e-18 65.6 14.3 7.5e-18 64.9 14.3 1.4 1 1 0 1 1 1 1 SUR7/PalI family Rhabdo_glycop PF00974.18 ORX49883.1 - 0.14 10.6 0.1 4.1 5.7 0.0 2.1 2 0 0 2 2 2 0 Rhabdovirus spike glycoprotein Bax1-I PF01027.20 ORX49883.1 - 1.2 8.9 17.9 0.11 12.3 11.6 2.2 2 1 0 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 ABC2_membrane_2 PF12679.7 ORX49883.1 - 1.7 7.8 10.5 0.044 13.1 4.4 1.5 2 0 0 2 2 2 0 ABC-2 family transporter protein Amidohydro_1 PF01979.20 ORX49884.1 - 1.4e-19 70.7 0.0 1.7e-18 67.0 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX49884.1 - 2e-11 44.0 0.2 7.9e-07 28.9 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family SNase PF00565.17 ORX49885.1 - 2.9e-55 185.3 2.4 3.2e-18 66.2 0.0 5.5 5 0 0 5 5 5 5 Staphylococcal nuclease homologue TUDOR PF00567.24 ORX49885.1 - 3.1e-30 104.7 0.0 7e-30 103.6 0.0 1.6 1 0 0 1 1 1 1 Tudor domain Agenet PF05641.12 ORX49885.1 - 0.1 13.1 0.3 0.34 11.4 0.1 2.1 2 0 0 2 2 2 0 Agenet domain Prefoldin_2 PF01920.20 ORX49886.1 - 1.4e-05 25.0 0.6 2e-05 24.5 0.6 1.2 1 0 0 1 1 1 1 Prefoldin subunit Glyco_hydro_47 PF01532.20 ORX49888.1 - 1.1e-117 393.8 0.0 1.5e-117 393.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 PA PF02225.22 ORX49889.1 - 2.4e-11 43.5 0.0 1.5e-10 40.9 0.0 2.1 1 1 0 1 1 1 1 PA domain Whi5 PF08528.11 ORX49890.1 - 0.089 12.4 0.3 0.14 11.8 0.3 1.4 1 0 0 1 1 1 0 Whi5 like SPRY PF00622.28 ORX49891.1 - 5.3e-13 49.2 0.1 8.5e-13 48.5 0.1 1.3 1 0 0 1 1 1 1 SPRY domain zf-C3HC4_3 PF13920.6 ORX49891.1 - 1.6e-11 43.9 0.9 3.1e-11 43.0 0.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX49891.1 - 0.00047 19.9 3.5 0.0012 18.7 3.5 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ORX49891.1 - 0.069 13.0 2.7 0.25 11.2 2.8 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX49891.1 - 0.32 10.9 5.8 0.46 10.4 4.4 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX49891.1 - 0.47 10.4 2.7 1.2 9.2 2.7 1.7 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 ORX49891.1 - 2.6 8.4 12.0 0.039 14.3 3.8 2.3 2 0 0 2 2 2 0 Ring finger domain DSPc PF00782.20 ORX49892.1 - 2.6e-06 27.3 0.0 4.2e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX49892.1 - 6.1e-06 26.0 0.0 7.3e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ORX49892.1 - 0.025 14.3 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ORX49892.1 - 0.026 14.7 0.0 0.033 14.3 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate RabGAP-TBC PF00566.18 ORX49893.1 - 2.3e-55 187.6 1.8 2.3e-55 187.6 1.8 2.1 2 1 0 2 2 2 1 Rab-GTPase-TBC domain TMF_TATA_bd PF12325.8 ORX49893.1 - 4.7e-05 23.6 14.5 0.00019 21.6 4.9 2.8 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding GAS PF13851.6 ORX49893.1 - 0.0061 15.9 12.9 0.014 14.7 12.9 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ORX49893.1 - 0.0093 16.0 16.5 0.0093 16.0 16.5 2.3 2 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1241 PF06840.11 ORX49893.1 - 0.024 14.3 3.6 0.033 13.8 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1241) DUF2205 PF10224.9 ORX49893.1 - 0.14 12.2 10.9 2.8 8.0 0.8 3.6 3 0 0 3 3 3 0 Short coiled-coil protein FlxA PF14282.6 ORX49893.1 - 0.18 11.8 13.1 0.59 10.2 8.1 2.6 1 1 1 2 2 2 0 FlxA-like protein DUF3450 PF11932.8 ORX49893.1 - 0.23 10.8 16.2 0.037 13.3 8.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 ORX49893.1 - 0.34 10.7 8.3 0.11 12.3 3.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 ORX49893.1 - 0.36 11.3 10.3 0.71 10.3 1.1 3.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Fez1 PF06818.15 ORX49893.1 - 0.47 10.9 11.8 1.2 9.6 11.8 1.7 1 0 0 1 1 1 0 Fez1 KLRAQ PF10205.9 ORX49893.1 - 0.53 10.6 16.0 5.9 7.2 1.9 3.9 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein KASH_CCD PF14662.6 ORX49893.1 - 0.56 10.0 17.3 0.93 9.3 12.4 2.3 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Vac_Fusion PF02346.16 ORX49893.1 - 0.57 9.9 6.6 6 6.6 0.5 4.1 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Bap31_Bap29_C PF18035.1 ORX49893.1 - 0.64 10.1 7.4 0.32 11.0 0.7 3.7 4 1 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain ADIP PF11559.8 ORX49893.1 - 0.72 9.9 14.6 0.43 10.6 7.8 2.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 ORX49893.1 - 0.79 10.4 15.4 0.27 11.9 4.2 3.4 1 1 2 3 3 3 0 Initiation control protein YabA UPF0242 PF06785.11 ORX49893.1 - 0.98 9.5 15.1 8.3 6.5 15.1 2.2 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 ORX49893.1 - 1.4 9.0 8.8 0.47 10.5 4.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 ORX49893.1 - 1.9 8.3 21.2 0.14 11.9 3.0 4.3 1 1 3 4 4 4 0 Septum formation initiator TEX13 PF15186.6 ORX49893.1 - 2.1 8.0 7.6 0.38 10.4 3.1 2.0 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family ZapB PF06005.12 ORX49893.1 - 2.3 8.7 18.9 6.1 7.4 2.1 4.1 2 1 2 4 4 4 0 Cell division protein ZapB Cep57_CLD_2 PF14197.6 ORX49893.1 - 2.8 8.1 14.3 0.1 12.7 5.4 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF4201 PF13870.6 ORX49893.1 - 5.2 6.8 19.5 0.11 12.3 6.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) TPR_MLP1_2 PF07926.12 ORX49893.1 - 6.3 6.9 21.5 0.062 13.4 9.1 3.0 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein His_Phos_1 PF00300.22 ORX49895.1 - 2.9e-40 138.1 1.5 3.7e-40 137.7 1.5 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF2781 PF10914.8 ORX49896.1 - 2.5e-41 141.5 12.6 2.8e-41 141.4 12.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) YafO_toxin PF13957.6 ORX49896.1 - 0.16 12.0 0.0 0.3 11.2 0.0 1.3 1 0 0 1 1 1 0 Toxin YafO, type II toxin-antitoxin system ADH_zinc_N_2 PF13602.6 ORX49899.1 - 3.4e-18 67.0 0.0 5.7e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ORX49899.1 - 1.9e-14 53.7 0.9 3.6e-14 52.8 0.9 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX49899.1 - 2.9e-09 36.8 2.5 4.5e-09 36.2 0.1 2.3 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain DUF2855 PF11017.8 ORX49899.1 - 6.2e-05 22.9 0.0 0.00012 22.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2855) LMBR1 PF04791.16 ORX49900.1 - 5.5e-119 398.4 19.1 6.6e-119 398.1 19.1 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein ATG27 PF09451.10 ORX49900.1 - 0.08 12.8 0.4 0.19 11.5 0.4 1.5 1 0 0 1 1 1 0 Autophagy-related protein 27 DUF1772 PF08592.11 ORX49900.1 - 0.71 10.2 11.6 0.085 13.2 1.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1772) MitoNEET_N PF10660.9 ORX49900.1 - 1.2 9.2 6.9 0.3 11.1 0.4 2.8 3 0 0 3 3 3 0 Iron-containing outer mitochondrial membrane protein N-terminus Arm PF00514.23 ORX49901.1 - 5.4e-10 39.0 7.8 0.42 10.7 0.0 6.3 7 0 0 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX49901.1 - 9.1e-07 29.3 0.6 0.49 11.0 0.0 5.5 7 0 0 7 7 7 2 HEAT-like repeat HEAT_2 PF13646.6 ORX49901.1 - 4.5e-06 27.0 0.4 0.3 11.5 0.0 5.1 3 2 2 5 5 5 2 HEAT repeats HEAT PF02985.22 ORX49901.1 - 0.00017 21.6 3.0 6.7 7.3 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat IBB PF01749.20 ORX49901.1 - 0.00057 20.3 2.3 0.0016 18.9 2.3 1.8 1 0 0 1 1 1 1 Importin beta binding domain Adaptin_N PF01602.20 ORX49901.1 - 0.0033 16.1 0.4 0.41 9.1 0.2 2.9 2 1 0 2 2 2 2 Adaptin N terminal region RNA_pol_Rpc82 PF05645.13 ORX49902.1 - 3.5e-18 66.3 0.4 3.5e-18 66.3 0.4 2.4 1 1 1 2 2 2 2 RNA polymerase III subunit RPC82 TFIIE_alpha PF02002.17 ORX49902.1 - 0.0032 17.3 3.6 0.012 15.5 0.1 3.5 2 2 0 3 3 3 1 TFIIE alpha subunit HTH_9 PF08221.11 ORX49902.1 - 0.011 15.9 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_9 PF08221.11 ORX49903.1 - 1.6e-17 63.4 0.0 1.9e-15 56.7 0.0 2.3 2 0 0 2 2 2 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 ORX49903.1 - 0.00023 21.0 0.1 0.014 15.3 0.0 2.1 2 0 0 2 2 2 2 TFIIE alpha subunit Glyco_hydro_25 PF01183.20 ORX49907.1 - 7.7e-09 36.0 0.9 8.9e-09 35.8 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 25 DUF1906 PF08924.11 ORX49907.1 - 0.00054 20.2 1.1 0.00082 19.6 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1906) Coatomer_E PF04733.14 ORX49908.1 - 1.4e-75 254.4 4.2 1.6e-75 254.2 4.2 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit ANAPC3 PF12895.7 ORX49908.1 - 1.8e-08 34.5 3.7 0.0029 17.8 1.5 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ORX49908.1 - 4e-06 27.2 13.8 0.0045 17.5 0.1 4.6 3 1 2 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX49908.1 - 5.9e-06 26.5 5.8 0.00023 21.4 0.0 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.9 ORX49908.1 - 0.00028 20.6 0.1 0.016 14.9 0.0 2.6 1 1 2 3 3 3 2 26S proteasome subunit RPN7 TPR_16 PF13432.6 ORX49908.1 - 0.0034 18.0 6.9 0.2 12.3 0.1 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX49908.1 - 0.009 15.7 2.2 1.5 8.5 0.1 3.9 4 0 0 4 4 4 1 TPR repeat SRP_TPR_like PF17004.5 ORX49908.1 - 0.0097 15.9 2.3 1.3 9.1 0.3 2.8 1 1 2 3 3 3 2 Putative TPR-like repeat TPR_8 PF13181.6 ORX49908.1 - 0.017 15.3 1.5 3.6 8.0 0.2 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX49908.1 - 0.019 15.1 0.1 0.019 15.1 0.1 4.8 6 0 0 6 6 4 0 Tetratricopeptide repeat PUL PF08324.11 ORX49908.1 - 0.028 13.6 1.9 0.57 9.4 0.4 2.4 2 1 0 2 2 2 0 PUL domain TPR_14 PF13428.6 ORX49908.1 - 0.041 14.7 9.5 3 8.9 0.0 4.8 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX49908.1 - 0.045 13.6 5.5 1.1 9.2 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 ORX49908.1 - 0.14 11.9 5.9 0.33 10.6 2.4 2.2 1 1 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_4 PF07721.14 ORX49908.1 - 0.18 12.5 4.3 4.4 8.2 0.1 4.5 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ORX49908.1 - 0.21 11.9 4.4 30 5.0 0.0 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat SNCAIP_SNCA_bd PF16700.5 ORX49908.1 - 0.25 11.1 0.1 0.25 11.1 0.1 2.4 3 0 0 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain TPR_1 PF00515.28 ORX49908.1 - 0.41 10.6 0.1 0.41 10.6 0.1 4.1 5 1 0 5 5 3 0 Tetratricopeptide repeat Flavoprotein PF02441.19 ORX49909.1 - 3e-50 170.1 0.2 3.4e-50 169.9 0.2 1.0 1 0 0 1 1 1 1 Flavoprotein Glyco_hydro_20 PF00728.22 ORX49910.1 - 4.4e-94 315.8 1.5 5.5e-94 315.4 1.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX49910.1 - 7.3e-18 65.5 0.0 2.2e-17 64.0 0.0 1.8 2 0 0 2 2 2 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX49910.1 - 6.8e-06 26.9 0.0 1.4e-05 25.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 AP_endonuc_2 PF01261.24 ORX49910.1 - 0.0044 16.5 0.2 0.087 12.3 0.0 2.6 2 1 1 3 3 3 1 Xylose isomerase-like TIM barrel GATA PF00320.27 ORX49911.1 - 1.4e-17 63.0 2.8 3e-17 61.9 2.8 1.6 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 ORX49911.1 - 1.2e-14 53.8 0.7 2.6e-14 52.7 0.7 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) LrgB PF04172.16 ORX49912.1 - 6.8e-37 127.1 18.9 2.5e-36 125.2 18.9 2.0 1 1 0 1 1 1 1 LrgB-like family LrgA PF03788.14 ORX49912.1 - 7e-10 38.7 4.5 7e-10 38.7 4.5 4.0 5 1 0 5 5 5 1 LrgA family TMEM52 PF14979.6 ORX49912.1 - 7.6 6.4 6.9 1.1e+02 2.7 5.3 2.6 2 0 0 2 2 2 0 Transmembrane 52 UDG PF03167.19 ORX49913.1 - 3.8e-21 75.7 0.0 4.7e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily CDKN3 PF05706.12 ORX49913.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) SH3_9 PF14604.6 ORX49914.1 - 1.2e-08 34.6 0.1 2.4e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX49914.1 - 7.2e-08 31.9 0.0 1.1e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX49914.1 - 2.7e-05 23.7 0.0 4.6e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain AA_permease_2 PF13520.6 ORX49915.1 - 4.3e-70 236.7 52.8 5.3e-70 236.4 52.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX49915.1 - 4e-25 88.4 40.8 5.5e-25 87.9 40.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF5336 PF17270.2 ORX49915.1 - 5 6.7 9.0 0.47 10.1 0.1 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5336) PSP1 PF04468.12 ORX49916.1 - 6.8e-33 112.8 4.1 1.1e-32 112.2 4.1 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region POTRA_3 PF17287.2 ORX49916.1 - 0.024 14.1 0.0 0.058 12.9 0.0 1.6 1 0 0 1 1 1 0 POTRA domain SR-25 PF10500.9 ORX49916.1 - 2 8.0 4.7 0.79 9.3 0.4 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein FHA PF00498.26 ORX49918.1 - 1e-18 67.4 0.0 1.8e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX49918.1 - 3.7e-08 33.6 0.0 8.6e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DDE_Tnp_1 PF01609.21 ORX49918.1 - 0.036 13.7 0.2 0.067 12.8 0.2 1.4 1 0 0 1 1 1 0 Transposase DDE domain Atg14 PF10186.9 ORX49918.1 - 0.24 10.4 2.6 0.32 10.0 2.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 T2SSF PF00482.23 ORX49918.1 - 0.25 11.3 0.3 0.43 10.5 0.3 1.4 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F CDC45 PF02724.14 ORX49918.1 - 0.43 8.8 12.9 0.56 8.4 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 ORX49918.1 - 1.7 6.4 5.0 2.4 5.9 5.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rieske PF00355.26 ORX49920.1 - 6.7e-08 32.4 0.1 1.4e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain SR-25 PF10500.9 ORX49920.1 - 0.0028 17.3 3.9 0.0028 17.3 3.9 2.3 2 0 0 2 2 2 2 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.12 ORX49920.1 - 7.2 5.1 22.0 33 2.9 0.0 2.1 1 1 1 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) IGR PF09597.10 ORX49921.1 - 7.4e-24 83.6 0.1 9.4e-24 83.3 0.1 1.1 1 0 0 1 1 1 1 IGR protein motif SAM_1 PF00536.30 ORX49921.1 - 0.17 12.4 0.0 0.26 11.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Hexokinase_2 PF03727.16 ORX49922.1 - 1.2e-67 227.9 0.0 1.8e-67 227.3 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX49922.1 - 4.5e-41 140.9 0.2 7.8e-41 140.2 0.2 1.4 1 0 0 1 1 1 1 Hexokinase Gly_acyl_tr_N PF06021.11 ORX49922.1 - 0.047 13.8 0.3 0.095 12.8 0.2 1.5 1 1 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase Oxysterol_BP PF01237.18 ORX49923.1 - 4.2e-52 177.2 6.7 5.2e-50 170.3 6.7 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein VPS9 PF02204.18 ORX49924.1 - 8.1e-33 112.8 0.0 1.9e-32 111.6 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 ORX49924.1 - 1.6e-13 50.8 0.6 1.6e-13 50.8 0.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF5601) CUE PF02845.16 ORX49924.1 - 1.6e-06 27.7 0.5 4.7e-06 26.2 0.5 1.9 1 0 0 1 1 1 1 CUE domain DUF3510 PF12022.8 ORX49924.1 - 0.0083 16.5 0.3 0.022 15.2 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3510) Androgen_recep PF02166.16 ORX49924.1 - 0.033 13.1 11.5 0.076 11.8 11.5 1.7 1 0 0 1 1 1 0 Androgen receptor CagX PF03524.15 ORX49924.1 - 0.037 13.8 1.5 0.083 12.6 1.5 1.5 1 0 0 1 1 1 0 Conjugal transfer protein RBP_receptor PF14752.6 ORX49924.1 - 0.19 10.3 0.8 4.1 5.8 0.5 2.0 2 0 0 2 2 2 0 Retinol binding protein receptor ACBP PF00887.19 ORX49925.1 - 3e-30 104.3 0.5 3.3e-30 104.1 0.5 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein Peptidase_M24 PF00557.24 ORX49928.1 - 5.8e-55 186.2 0.0 7.6e-55 185.8 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ORX49928.1 - 1.1e-36 125.2 0.0 1.9e-36 124.5 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain SPOUT_MTase_2 PF14419.6 ORX49928.1 - 0.15 11.4 0.1 13 5.1 0.0 2.2 2 0 0 2 2 2 0 AF2226-like SPOUT RNA Methylase fused to THUMP zf-CCCH_4 PF18044.1 ORX49929.1 - 0.19 11.6 1.6 0.35 10.7 1.6 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Peptidase_M24 PF00557.24 ORX49932.1 - 2.3e-33 115.7 0.4 1.2e-17 64.3 0.0 2.0 1 1 1 2 2 2 2 Metallopeptidase family M24 Hexapep_2 PF14602.6 ORX49932.1 - 0.6 9.9 2.8 1.2 8.9 1.6 2.0 2 0 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Dus PF01207.17 ORX49933.1 - 6e-57 193.1 0.0 1e-56 192.4 0.0 1.3 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 ORX49933.1 - 6.1e-07 29.1 12.1 3e-05 23.7 0.4 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH PF00642.24 ORX49933.1 - 7.7e-05 22.5 13.9 0.00023 21.0 0.2 3.4 4 0 0 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX49933.1 - 0.026 14.6 2.1 0.026 14.6 2.1 2.8 3 0 0 3 3 3 0 Zinc finger domain Torus PF16131.5 ORX49933.1 - 3.5 8.4 7.5 6.1 7.6 1.6 2.5 1 1 1 2 2 2 0 Torus domain zf-CCCH_2 PF14608.6 ORX49933.1 - 4.2 8.0 10.3 3.9 8.1 1.0 2.8 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Pkinase PF00069.25 ORX49934.1 - 6.3e-53 179.8 0.1 1.2e-52 178.9 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX49934.1 - 3.4e-21 75.7 0.0 1.2e-20 73.9 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX49934.1 - 8.6e-05 22.6 0.0 0.00018 21.5 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX49934.1 - 0.029 13.9 0.0 0.072 12.7 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase RIO1 PF01163.22 ORX49934.1 - 0.084 12.5 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Helicase_Sgs1 PF11408.8 ORX49934.1 - 0.16 12.0 0.4 3.5 7.7 0.0 2.7 3 0 0 3 3 3 0 Sgs1 RecQ helicase MFS_1 PF07690.16 ORX49935.1 - 1.7e-34 119.4 59.5 1.7e-18 66.7 18.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX49935.1 - 2.1e-07 29.8 26.4 6.1e-07 28.3 17.5 2.1 1 1 1 2 2 2 2 MFS/sugar transport protein Ses_B PF17046.5 ORX49935.1 - 0.073 13.0 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 SesB domain on fungal death-pathway protein bZIP_2 PF07716.15 ORX49936.1 - 7.2e-10 38.8 13.3 1.7e-09 37.6 13.3 1.7 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX49936.1 - 0.00077 19.5 8.8 0.00077 19.5 8.8 1.7 2 0 0 2 2 2 1 bZIP transcription factor XhlA PF10779.9 ORX49936.1 - 0.0092 16.2 1.8 0.016 15.4 1.8 1.3 1 0 0 1 1 1 1 Haemolysin XhlA Matrilin_ccoil PF10393.9 ORX49936.1 - 0.039 13.8 3.2 0.049 13.5 0.9 2.0 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Golgin_A5 PF09787.9 ORX49936.1 - 0.05 13.1 8.3 0.085 12.3 8.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1192 PF06698.11 ORX49936.1 - 0.11 12.6 1.9 0.32 11.1 1.9 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) Fib_alpha PF08702.10 ORX49936.1 - 0.61 10.3 5.7 3.4 7.8 4.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ECM11 PF15463.6 ORX49936.1 - 1.4 9.5 13.1 0.43 11.2 5.3 2.6 2 1 0 2 2 2 0 Extracellular mutant protein 11 HSBP1 PF06825.12 ORX49936.1 - 2.5 8.0 8.5 0.7 9.8 0.1 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 WD40 PF00400.32 ORX49937.1 - 3.6e-51 170.0 23.7 1.1e-07 32.4 0.1 8.5 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 ORX49937.1 - 1.1e-13 50.9 0.2 2.3e-13 49.8 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX49937.1 - 1.5e-09 37.5 0.1 3.9e-09 36.2 0.1 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ORX49937.1 - 9.7e-07 27.8 14.1 0.24 10.0 0.1 6.1 4 3 2 6 6 6 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ORX49937.1 - 1.8e-06 28.1 2.2 0.2 11.9 0.1 5.1 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ORX49937.1 - 3.7e-05 23.7 0.0 3.4 7.7 0.0 4.0 3 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ORX49937.1 - 0.0061 16.2 0.0 19 5.0 0.0 4.2 5 0 0 5 5 5 0 HepA-related protein (HARP) WD40_like PF17005.5 ORX49937.1 - 0.014 14.7 0.0 18 4.5 0.0 3.1 3 0 0 3 3 3 0 WD40-like domain PALB2_WD40 PF16756.5 ORX49937.1 - 0.029 13.3 8.3 1.3 7.9 0.0 4.7 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain F-box_4 PF15966.5 ORX49937.1 - 0.046 13.6 0.2 0.37 10.7 0.0 2.3 2 0 0 2 2 2 0 F-box Peptidase_Mx PF15887.5 ORX49937.1 - 0.071 12.5 0.0 0.19 11.1 0.0 1.7 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase SRP19 PF01922.17 ORX50096.1 - 1e-28 100.1 0.1 2.1e-28 99.1 0.1 1.5 1 0 0 1 1 1 1 SRP19 protein DUF5595 PF18077.1 ORX50096.1 - 0.072 13.2 0.2 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) CoA_transf_3 PF02515.17 ORX50097.1 - 1.1e-128 429.5 0.0 1.2e-128 429.3 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III Cthe_2159 PF14262.6 ORX50098.1 - 0.023 14.0 0.5 0.058 12.7 0.5 1.5 1 1 0 1 1 1 0 Carbohydrate-binding domain-containing protein Cthe_2159 SBE2 PF17076.5 ORX50098.1 - 0.081 11.1 0.0 0.084 11.1 0.0 1.0 1 0 0 1 1 1 0 SBE2, cell-wall formation Peroxin-13_N PF04088.13 ORX50098.1 - 0.55 10.5 5.0 13 6.0 1.4 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region C6 PF01681.17 ORX50098.1 - 0.68 10.5 16.8 2.2 8.9 4.6 2.3 1 1 1 2 2 2 0 C6 domain Vps54 PF07928.12 ORX50098.1 - 0.78 10.2 14.9 2.5 8.5 1.1 3.3 1 1 2 3 3 3 0 Vps54-like protein Spc7_C2 PF15577.6 ORX50098.1 - 1.2 9.3 7.4 6.6 6.9 0.8 2.8 1 1 1 2 2 2 0 Spc7_C2 Transketolase_N PF00456.21 ORX50099.1 - 1.7e-154 513.8 0.0 2.2e-154 513.4 0.0 1.1 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ORX50099.1 - 3e-44 150.8 0.0 5.1e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX50099.1 - 9.1e-14 51.4 0.0 2.6e-13 49.9 0.0 1.8 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ORX50099.1 - 3.3e-07 29.8 0.0 1.9e-05 24.0 0.0 2.0 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase Terpene_synth PF01397.21 ORX50099.1 - 0.098 12.3 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain Alba PF01918.21 ORX50099.1 - 0.15 11.9 0.1 0.72 9.7 0.0 2.2 3 0 0 3 3 3 0 Alba Beta_elim_lyase PF01212.21 ORX50099.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase DUF498 PF04430.14 ORX50099.1 - 0.18 11.9 0.0 1.3 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF498/DUF598) CP12 PF02672.15 ORX50099.1 - 0.28 12.0 0.4 8.9 7.2 0.0 2.4 2 0 0 2 2 2 0 CP12 domain Sec23_trunk PF04811.15 ORX50100.1 - 1.1e-60 205.2 0.0 2.6e-58 197.4 0.0 2.4 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ORX50100.1 - 8.3e-26 89.8 0.2 1.5e-25 89.0 0.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ORX50100.1 - 3e-16 59.2 2.6 6.5e-16 58.1 2.6 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 ORX50100.1 - 3.3e-16 59.8 0.0 6.3e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 ORX50100.1 - 2.5e-10 40.1 0.0 1e-09 38.2 0.0 2.1 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 ORX50100.1 - 0.014 16.0 0.0 0.052 14.2 0.0 2.0 1 0 0 1 1 1 0 von Willebrand factor type A domain VWA PF00092.28 ORX50100.1 - 0.055 13.7 0.0 0.096 12.9 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain Vps36-NZF-N PF16988.5 ORX50100.1 - 0.08 12.4 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain WD40 PF00400.32 ORX50101.1 - 3.3e-58 192.3 10.7 2.9e-08 34.2 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 ORX50101.1 - 2.1e-23 82.4 14.0 3.1e-23 81.8 14.0 1.2 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 ORX50101.1 - 4.6e-20 71.7 0.0 0.00011 22.4 0.0 6.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX50101.1 - 8.7e-08 31.8 0.0 0.035 13.4 0.0 4.0 4 0 0 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ORX50101.1 - 9.4e-08 31.4 0.0 1.2 8.0 0.0 4.9 1 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Spc7 PF08317.11 ORX50101.1 - 3e-06 26.3 2.9 4.3e-06 25.8 2.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein SHE3 PF17078.5 ORX50101.1 - 0.0011 18.8 3.1 0.0016 18.2 3.1 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Nbas_N PF15492.6 ORX50101.1 - 0.0035 16.7 0.0 4.2 6.6 0.0 3.1 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ORX50101.1 - 0.007 14.9 0.3 0.11 11.0 0.0 2.7 2 2 0 2 2 2 1 Cytochrome D1 heme domain DUF3450 PF11932.8 ORX50101.1 - 0.013 14.8 9.1 0.022 14.0 9.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF5122 PF17164.4 ORX50101.1 - 0.014 15.7 1.8 19 5.7 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller Jnk-SapK_ap_N PF09744.9 ORX50101.1 - 0.017 15.3 9.7 0.027 14.7 9.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 CEP63 PF17045.5 ORX50101.1 - 0.029 14.3 7.5 0.047 13.6 7.5 1.3 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Golgin_A5 PF09787.9 ORX50101.1 - 0.036 13.5 9.5 0.052 13.0 9.5 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 CENP-H PF05837.12 ORX50101.1 - 0.04 14.3 2.7 0.074 13.5 2.7 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) AIP3 PF03915.13 ORX50101.1 - 0.048 12.8 1.6 0.068 12.3 1.6 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 Sec1 PF00995.23 ORX50101.1 - 0.056 12.7 2.9 0.08 12.2 2.9 1.1 1 0 0 1 1 1 0 Sec1 family Leu_zip PF15294.6 ORX50101.1 - 0.064 12.8 4.3 0.096 12.2 4.3 1.1 1 0 0 1 1 1 0 Leucine zipper APG6_N PF17675.1 ORX50101.1 - 0.086 13.4 9.1 0.15 12.6 9.1 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4449 PF14613.6 ORX50101.1 - 0.11 12.6 1.7 0.18 11.9 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) DUF724 PF05266.14 ORX50101.1 - 0.18 11.6 3.8 0.27 11.0 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 ORX50101.1 - 0.19 11.0 4.3 0.27 10.4 4.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein PD40 PF07676.12 ORX50101.1 - 0.38 10.8 3.2 12 6.0 0.0 4.5 6 0 0 6 6 3 0 WD40-like Beta Propeller Repeat Exonuc_VII_L PF02601.15 ORX50101.1 - 0.94 9.0 3.4 1.6 8.2 3.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CREPT PF16566.5 ORX50101.1 - 1.1 9.4 5.9 1.8 8.7 5.9 1.2 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour DUF1640 PF07798.11 ORX50101.1 - 1.1 9.2 9.8 2.2 8.3 9.0 1.8 2 1 0 2 2 1 0 Protein of unknown function (DUF1640) HemX PF04375.14 ORX50101.1 - 1.1 8.4 8.8 1.7 7.8 8.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF5094 PF17015.5 ORX50101.1 - 1.5 8.9 5.4 16 5.6 5.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) Uso1_p115_C PF04871.13 ORX50101.1 - 1.7 9.0 8.3 2.6 8.4 8.3 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ZapB PF06005.12 ORX50101.1 - 3.6 8.1 16.2 2 8.9 11.7 2.2 1 1 1 2 2 2 0 Cell division protein ZapB SlyX PF04102.12 ORX50101.1 - 5.4 7.7 8.8 50 4.6 1.3 2.6 1 1 1 2 2 2 0 SlyX RRP36 PF06102.12 ORX50101.1 - 5.8 6.9 7.9 9.6 6.1 7.9 1.2 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 HalX PF08663.10 ORX50101.1 - 7.6 6.9 6.4 61 4.0 6.4 2.1 1 1 0 1 1 1 0 HalX domain RINT1_TIP1 PF04437.13 ORX50102.1 - 2.6e-106 356.5 2.9 4.1e-106 355.8 2.9 1.3 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DUF2757 PF10955.8 ORX50102.1 - 0.018 15.3 0.1 0.057 13.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) CS PF04969.16 ORX50103.1 - 2.3e-07 31.7 0.0 5e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 CS domain 5-FTHF_cyc-lig PF01812.20 ORX50104.1 - 9.4e-49 165.8 0.1 1.1e-48 165.6 0.1 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Phos_pyr_kin PF08543.12 ORX50105.1 - 1.1e-15 57.8 0.1 4.3e-15 55.8 0.1 1.8 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ORX50105.1 - 4.7e-07 29.4 0.1 1.4e-06 27.8 0.0 1.8 3 0 0 3 3 3 1 pfkB family carbohydrate kinase Glutaredoxin PF00462.24 ORX50106.1 - 1.1e-14 54.4 0.0 1.6e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin TraF PF13728.6 ORX50106.1 - 0.016 15.0 0.0 0.02 14.8 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein DUF836 PF05768.14 ORX50106.1 - 0.055 13.9 0.0 0.08 13.4 0.0 1.5 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Arrestin_N PF00339.29 ORX50107.1 - 2.6e-06 27.6 0.0 4.7e-05 23.5 0.0 2.8 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 ORX50107.1 - 0.17 11.0 0.1 0.44 9.7 0.1 1.6 2 0 0 2 2 2 0 Rgp1 WD-3 PF09765.9 ORX50108.1 - 1.4e-49 168.9 0.0 2.3e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 WD-repeat region FANCL_C PF11793.8 ORX50108.1 - 4.5e-22 78.0 4.9 1.1e-21 76.8 4.9 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 ORX50108.1 - 7e-06 26.3 5.7 1.8e-05 25.0 5.7 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX50108.1 - 0.0015 18.8 6.0 0.0034 17.6 6.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain PHD PF00628.29 ORX50108.1 - 0.0059 16.5 3.6 0.013 15.4 3.6 1.6 1 0 0 1 1 1 1 PHD-finger zf-ANAPC11 PF12861.7 ORX50108.1 - 0.039 14.0 3.8 0.098 12.7 3.7 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-HC5HC2H PF13771.6 ORX50108.1 - 0.12 12.7 7.6 0.11 12.8 6.1 1.7 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING-like PF08746.11 ORX50108.1 - 0.23 11.8 2.7 0.76 10.1 2.7 1.9 1 1 0 1 1 1 0 RING-like domain DUF572 PF04502.13 ORX50109.1 - 1.7e-78 264.6 2.5 2e-78 264.3 2.5 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DNA_Packaging_2 PF11123.8 ORX50109.1 - 0.047 13.9 0.4 0.1 12.8 0.4 1.6 1 0 0 1 1 1 0 DNA packaging protein DUF4451 PF14616.6 ORX50109.1 - 0.33 11.2 2.4 0.54 10.5 1.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4451) CAS_CSE1 PF03378.15 ORX50110.1 - 0.058 11.9 0.0 0.092 11.2 0.0 1.3 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Ycf34 PF10718.9 ORX50110.1 - 0.2 12.4 0.1 0.37 11.5 0.1 1.4 1 0 0 1 1 1 0 Hypothetical chloroplast protein Ycf34 Cyt-b5 PF00173.28 ORX50111.1 - 9.4e-25 86.6 0.1 1.2e-24 86.2 0.1 1.1 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Gln-synt_C PF00120.24 ORX50112.1 - 4.3e-88 295.6 0.0 5.1e-88 295.4 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain HDAC4_Gln PF12203.8 ORX50112.1 - 0.025 14.7 0.3 0.046 13.9 0.3 1.3 1 0 0 1 1 1 0 Glutamine rich N terminal domain of histone deacetylase 4 FumaraseC_C PF10415.9 ORX50112.1 - 0.18 12.3 0.4 1.3 9.5 0.0 2.4 2 0 0 2 2 2 0 Fumarase C C-terminus Coprogen_oxidas PF01218.18 ORX50113.1 - 9.1e-104 346.3 0.1 1e-103 346.2 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase RNB PF00773.19 ORX50114.1 - 6.8e-59 199.8 0.0 4.6e-58 197.1 0.0 2.1 1 1 0 1 1 1 1 RNB domain XRN1_DBM PF18245.1 ORX50114.1 - 0.085 12.8 0.1 0.41 10.7 0.1 2.2 1 0 0 1 1 1 0 5-3 exonuclease XRN1 DCP1-binding motif WD40 PF00400.32 ORX50115.1 - 7.4e-24 83.6 12.8 1.9e-06 28.5 0.1 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX50115.1 - 4.1e-11 43.0 0.5 0.00067 19.9 0.0 4.0 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX50115.1 - 8.8e-08 32.2 0.1 6.7e-07 29.4 0.2 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ORX50115.1 - 0.00036 19.9 0.5 0.038 13.3 0.1 3.1 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ORX50115.1 - 0.0012 18.3 0.1 0.082 12.2 0.0 2.3 1 1 1 2 2 2 2 WD40-like domain Frtz PF11768.8 ORX50115.1 - 0.069 11.5 0.0 0.32 9.3 0.0 1.8 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz GPI-anchored PF10342.9 ORX50116.1 - 4.3e-15 56.3 3.2 4.3e-15 56.3 3.2 1.6 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Methyltransf_12 PF08242.12 ORX50117.1 - 4e-16 59.6 0.0 1.4e-15 57.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX50117.1 - 4.2e-16 59.2 0.0 7.8e-16 58.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX50117.1 - 2.1e-14 54.0 0.0 4.7e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX50117.1 - 2e-11 44.4 0.0 4.8e-11 43.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX50117.1 - 1.3e-08 34.7 0.0 2.4e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX50117.1 - 0.00062 19.2 0.0 0.00099 18.5 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family NNMT_PNMT_TEMT PF01234.17 ORX50117.1 - 0.0015 17.7 0.0 0.046 12.9 0.0 2.1 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family CMAS PF02353.20 ORX50117.1 - 0.013 14.8 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_4 PF02390.17 ORX50117.1 - 0.031 13.8 0.0 0.079 12.4 0.0 1.7 1 0 0 1 1 1 0 Putative methyltransferase TPMT PF05724.11 ORX50117.1 - 0.032 13.9 0.1 0.032 13.9 0.1 1.9 2 1 0 2 2 2 0 Thiopurine S-methyltransferase (TPMT) Methyltransf_24 PF13578.6 ORX50117.1 - 0.041 14.9 0.0 0.1 13.6 0.0 1.7 2 0 0 2 2 1 0 Methyltransferase domain CheR PF01739.18 ORX50117.1 - 0.079 12.4 0.0 5.1 6.5 0.0 2.4 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain MTS PF05175.14 ORX50117.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain TPR_1 PF00515.28 ORX50118.1 - 3.9e-52 172.0 34.2 6.2e-08 32.1 0.1 10.6 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ORX50118.1 - 4.2e-47 154.5 31.4 4.6e-07 29.5 0.1 10.3 11 0 0 11 11 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ORX50118.1 - 7.4e-35 116.2 28.3 1.5e-05 24.8 0.0 10.7 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 ORX50118.1 - 6.8e-28 97.0 9.8 1.8e-06 28.5 0.1 6.7 4 1 3 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 ORX50118.1 - 8.3e-26 88.5 26.5 0.00078 19.7 0.1 10.2 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 ORX50118.1 - 4.2e-25 86.3 12.2 4.6e-05 23.9 0.1 8.3 4 3 4 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 ORX50118.1 - 1.8e-24 85.8 24.0 2.5e-05 24.5 0.2 6.8 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_19 PF14559.6 ORX50118.1 - 2.1e-24 85.8 17.6 0.00015 22.2 0.4 6.3 5 2 1 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ORX50118.1 - 1e-20 73.1 40.7 8.9e-06 25.3 1.4 9.0 4 2 5 9 9 9 5 TPR repeat TPR_7 PF13176.6 ORX50118.1 - 2.3e-19 67.9 20.8 0.037 14.0 0.5 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 ORX50118.1 - 7.4e-19 67.7 11.3 0.00035 20.7 0.4 6.7 1 1 5 7 7 7 6 Tetratricopeptide repeat TPR_6 PF13174.6 ORX50118.1 - 3.8e-17 61.7 25.8 0.00028 21.3 0.0 9.1 10 0 0 10 10 9 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX50118.1 - 4.7e-10 39.5 20.3 5.1e-06 26.6 5.3 3.6 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ORX50118.1 - 1.9e-09 37.1 12.3 0.044 13.0 0.3 5.1 1 1 2 5 5 5 3 Tetratricopeptide repeat TPR_21 PF09976.9 ORX50118.1 - 0.00049 19.9 6.5 0.65 9.7 0.0 4.3 3 1 0 4 4 4 1 Tetratricopeptide repeat-like domain TPR_20 PF14561.6 ORX50118.1 - 0.00054 20.2 1.5 10 6.5 0.1 5.0 2 2 3 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.6 ORX50118.1 - 0.00066 19.2 19.3 0.54 9.6 0.6 4.5 1 1 3 4 4 4 2 Soluble NSF attachment protein, SNAP DUF2225 PF09986.9 ORX50118.1 - 0.0012 18.6 5.6 0.26 11.0 1.3 2.8 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) Fis1_TPR_C PF14853.6 ORX50118.1 - 0.013 15.5 4.4 15 5.7 0.1 5.0 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Tcf25 PF04910.14 ORX50118.1 - 0.018 14.1 2.9 0.18 10.8 0.0 2.6 2 2 0 2 2 2 0 Transcriptional repressor TCF25 ChAPs PF09295.10 ORX50118.1 - 0.049 12.6 3.1 9.4 5.1 0.3 2.7 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_3 PF07720.12 ORX50118.1 - 0.064 13.3 21.5 2.8 8.0 0.7 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX50118.1 - 0.097 12.6 25.4 10 6.1 1.2 7.6 8 0 0 8 8 8 0 Tetratricopeptide repeat TOM20_plant PF06552.12 ORX50118.1 - 0.11 12.2 0.5 32 4.2 0.0 3.5 3 0 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 Rapsyn_N PF10579.9 ORX50118.1 - 0.21 11.7 1.8 34 4.6 0.1 3.4 3 1 1 4 4 3 0 Rapsyn N-terminal myristoylation and linker region DUF627 PF04781.12 ORX50118.1 - 0.25 11.4 3.5 31 4.6 1.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF627) BTAD PF03704.17 ORX50118.1 - 0.66 10.4 12.4 8.4 6.8 0.1 3.4 3 0 0 3 3 3 0 Bacterial transcriptional activator domain Cellulase PF00150.18 ORX50120.1 - 2.4e-12 46.9 0.0 4.4e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DER1 PF04511.15 ORX50122.1 - 3.1e-51 174.1 6.9 3.5e-51 173.9 6.9 1.0 1 0 0 1 1 1 1 Der1-like family Methyltransf_25 PF13649.6 ORX50123.1 - 2.1e-07 31.5 0.0 0.00047 20.8 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ORX50123.1 - 2.1e-06 28.3 0.1 3.3e-05 24.4 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX50123.1 - 0.00061 19.7 0.0 0.004 17.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain PAP1 PF08601.10 ORX50124.1 - 3.9e-09 36.7 3.3 9.8e-07 28.8 0.0 2.4 2 1 1 3 3 3 2 Transcription factor PAP1 bZIP_1 PF00170.21 ORX50124.1 - 6.2e-07 29.4 15.8 1.1e-05 25.5 15.8 2.4 1 1 0 1 1 1 1 bZIP transcription factor DUF1515 PF07439.11 ORX50124.1 - 0.004 17.2 0.6 0.0083 16.1 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1515) PLC-beta_C PF08703.10 ORX50124.1 - 0.012 15.6 3.9 0.022 14.7 3.9 1.4 1 0 0 1 1 1 0 PLC-beta C terminal CLZ PF16526.5 ORX50124.1 - 0.014 15.7 7.9 0.031 14.7 7.9 1.6 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Jnk-SapK_ap_N PF09744.9 ORX50124.1 - 0.017 15.3 3.4 0.033 14.4 3.4 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Terminase_4 PF05119.12 ORX50124.1 - 0.025 15.0 1.3 0.087 13.3 0.3 2.2 2 0 0 2 2 2 0 Phage terminase, small subunit baeRF_family5 PF18846.1 ORX50124.1 - 0.033 14.4 2.0 0.072 13.3 2.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 bZIP_2 PF07716.15 ORX50124.1 - 0.09 12.9 21.7 12 6.1 21.7 2.5 1 1 0 1 1 1 0 Basic region leucine zipper DASH_Dad3 PF08656.10 ORX50124.1 - 0.11 12.5 0.5 1.2 9.3 0.4 2.3 2 0 0 2 2 2 0 DASH complex subunit Dad3 AAA_32 PF13654.6 ORX50124.1 - 0.13 11.0 3.3 0.17 10.6 3.3 1.1 1 0 0 1 1 1 0 AAA domain PSII PF00421.19 ORX50126.1 - 0.011 14.5 0.3 0.013 14.2 0.3 1.0 1 0 0 1 1 1 0 Photosystem II protein MHC2-interact PF09307.10 ORX50126.1 - 0.11 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 CLIP, MHC2 interacting HMG-CoA_red PF00368.18 ORX50128.1 - 1.3e-144 481.8 6.1 1.9e-144 481.2 6.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 ORX50128.1 - 4.6e-17 62.3 1.1 1.1e-16 61.1 1.1 1.5 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ORX50128.1 - 0.00048 18.3 5.7 0.0007 17.8 2.8 2.1 1 1 1 2 2 2 1 Patched family DUF2304 PF10066.9 ORX50128.1 - 0.085 13.1 1.8 0.41 10.9 1.8 2.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) PUF PF00806.19 ORX50129.1 - 3.4e-61 199.6 20.3 3.2e-09 36.0 0.4 8.2 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 ORX50129.1 - 4.8e-05 23.7 2.8 0.97 9.8 0.4 4.6 1 1 3 4 4 4 3 CPL (NUC119) domain TAN PF11640.8 ORX50129.1 - 0.049 13.7 0.4 0.34 11.0 0.1 2.5 1 1 2 3 3 3 0 Telomere-length maintenance and DNA damage repair DnaB_bind PF10410.9 ORX50129.1 - 0.14 12.4 0.0 1.5 9.1 0.0 2.7 3 0 0 3 3 3 0 DnaB-helicase binding domain of primase PAT1 PF09770.9 ORX50129.1 - 0.51 8.6 7.1 0.38 9.0 0.1 2.1 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RANK_CRD_2 PF18278.1 ORX50130.1 - 1.1 9.5 4.2 4.3 7.6 0.5 2.2 2 0 0 2 2 2 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 AKAP7_NLS PF10469.9 ORX50131.1 - 4.9e-05 23.3 0.0 6e-05 23.0 0.0 1.0 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX50131.1 - 0.11 12.4 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily RFX1_trans_act PF04589.13 ORX50132.1 - 0.011 15.9 0.5 0.013 15.7 0.5 1.0 1 0 0 1 1 1 0 RFX1 transcription activation region BBP1_N PF15271.6 ORX50132.1 - 0.038 14.8 1.5 0.049 14.4 1.5 1.1 1 0 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein PS_Dcarbxylase PF02666.15 ORX50134.1 - 5.5e-76 254.6 0.0 1.3e-57 194.6 0.0 2.6 2 1 1 3 3 3 2 Phosphatidylserine decarboxylase Na_Ca_ex PF01699.24 ORX50135.1 - 7.2e-42 142.9 51.0 1.2e-25 90.2 12.6 3.0 3 0 0 3 3 3 2 Sodium/calcium exchanger protein FA_desaturase PF00487.24 ORX50135.1 - 4.7 7.0 10.9 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 Fatty acid desaturase N-SET PF11764.8 ORX50136.1 - 7.2e-15 55.5 0.0 7.2e-15 55.5 0.0 3.4 3 1 1 4 4 4 1 COMPASS (Complex proteins associated with Set1p) component N RRM_1 PF00076.22 ORX50136.1 - 2.3e-09 36.9 0.0 6.1e-09 35.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET PF00856.28 ORX50136.1 - 6.2e-08 33.2 0.2 6.2e-08 33.2 0.2 2.5 2 1 0 2 2 2 1 SET domain SET_assoc PF11767.8 ORX50136.1 - 7e-06 25.6 0.1 2.5e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated Pkinase PF00069.25 ORX50137.1 - 1.1e-60 205.2 0.0 1.4e-60 204.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50137.1 - 4.4e-36 124.5 0.0 5.6e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX50137.1 - 2.2e-05 23.9 3.2 6.6e-05 22.4 3.2 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX50137.1 - 8.1e-05 22.1 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX50137.1 - 0.00071 18.5 0.1 0.0013 17.6 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX50137.1 - 0.0089 16.0 2.3 0.29 11.0 0.7 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX50137.1 - 0.12 11.3 0.7 0.16 10.9 0.1 1.5 2 0 0 2 2 2 0 Haspin like kinase domain Acyltransferase PF01553.21 ORX50138.1 - 1.8e-34 118.2 0.1 2.4e-34 117.9 0.1 1.1 1 0 0 1 1 1 1 Acyltransferase Cyclin_N PF00134.23 ORX50139.1 - 5.4e-13 48.8 0.7 1.1e-12 47.8 0.7 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain RE_BstXI PF09552.10 ORX50139.1 - 0.058 12.6 0.2 1.2 8.3 0.1 2.1 2 0 0 2 2 2 0 BstXI restriction endonuclease Mg_trans_NIPA PF05653.14 ORX50140.1 - 3.5e-17 62.5 19.2 8e-16 58.0 19.2 2.0 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX50140.1 - 0.011 15.9 2.5 0.011 15.9 2.5 3.1 2 1 0 2 2 2 0 EamA-like transporter family RhoGAP PF00620.27 ORX50141.1 - 1.4e-40 138.6 0.6 2.3e-40 137.9 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 ORX50141.1 - 4e-18 65.8 0.0 8.7e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 PH domain PX PF00787.24 ORX50141.1 - 2.4e-11 43.6 0.2 6.4e-11 42.2 0.2 1.7 1 0 0 1 1 1 1 PX domain PH_11 PF15413.6 ORX50141.1 - 3e-09 37.2 0.0 1.4e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ORX50141.1 - 6.6e-05 23.1 0.1 0.00043 20.5 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Shugoshin_N PF07558.11 ORX50141.1 - 0.0054 16.6 1.9 0.017 15.0 1.9 1.9 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region SHE3 PF17078.5 ORX50141.1 - 0.032 13.9 1.7 0.077 12.7 1.7 1.5 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 KASH_CCD PF14662.6 ORX50141.1 - 0.035 13.9 4.5 0.07 13.0 4.5 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH FPP PF05911.11 ORX50141.1 - 0.11 10.7 4.0 0.19 9.9 4.0 1.3 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil ThiD2 PF17792.1 ORX50141.1 - 0.12 12.9 0.7 0.36 11.3 0.7 1.8 1 0 0 1 1 1 0 ThiD2 family TMF_DNA_bd PF12329.8 ORX50141.1 - 0.12 12.3 7.2 0.16 12.0 4.0 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TMEM192 PF14802.6 ORX50141.1 - 0.18 10.9 0.5 0.36 9.9 0.5 1.4 1 0 0 1 1 1 0 TMEM192 family YabA PF06156.13 ORX50141.1 - 0.25 12.0 3.5 0.62 10.7 3.5 1.7 1 0 0 1 1 1 0 Initiation control protein YabA Cep57_MT_bd PF06657.13 ORX50141.1 - 0.25 11.8 4.6 0.091 13.2 0.7 2.4 2 0 0 2 2 1 0 Centrosome microtubule-binding domain of Cep57 GIT_CC PF16559.5 ORX50141.1 - 9.6 6.2 7.7 6.9 6.6 4.9 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor ENTH PF01417.20 ORX50142.1 - 8.6e-45 151.8 0.3 1.4e-44 151.2 0.3 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ORX50142.1 - 2.2e-05 23.6 0.2 3.4e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 ANTH domain DUF5102 PF17104.5 ORX50142.1 - 8.5 6.3 23.2 1.8 8.5 7.4 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) UDPGP PF01704.18 ORX50143.1 - 1.7e-201 669.3 0.4 1.9e-201 669.1 0.4 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Gly_transf_sug PF04488.15 ORX50144.1 - 0.0038 17.8 0.0 0.0061 17.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Phosphoesterase PF04185.14 ORX50146.1 - 6.5e-81 272.3 0.8 2.7e-80 270.2 0.8 1.7 1 1 0 1 1 1 1 Phosphoesterase family Phosphoesterase PF04185.14 ORX50147.1 - 7.9e-22 77.9 0.4 1.3e-20 73.9 0.4 2.0 1 1 0 1 1 1 1 Phosphoesterase family Ribosomal_L15e PF00827.17 ORX50149.1 - 4.7e-89 297.2 9.0 5.3e-89 297.0 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 PIP5K PF01504.18 ORX50150.1 - 3.1e-40 138.1 2.5 4.5e-33 114.6 2.8 2.4 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 ORX50150.1 - 6.8e-25 87.6 0.1 1.6e-24 86.4 0.0 1.5 2 0 0 2 2 2 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 ORX50150.1 - 9.1e-18 64.2 14.3 9.1e-18 64.2 14.3 1.9 2 0 0 2 2 2 1 FYVE zinc finger Ribosomal_L13 PF00572.18 ORX50151.1 - 4.6e-53 178.7 0.0 5.7e-53 178.4 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 Phage_holin_6_1 PF09682.10 ORX50151.1 - 0.18 12.2 0.0 0.24 11.9 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) LNS2 PF08235.13 ORX50152.1 - 1e-100 335.9 0.0 1.5e-100 335.4 0.0 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ORX50152.1 - 7.9e-40 135.0 0.1 1.4e-39 134.1 0.1 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 ORX50152.1 - 1.5e-15 57.1 0.0 3.2e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Lipin/Ned1/Smp2 multi-domain protein middle domain Collagen PF01391.18 ORX50153.1 - 0.0011 18.7 1.4 0.0019 17.9 1.4 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) DUF1180 PF06679.12 ORX50153.1 - 0.016 15.6 3.3 0.02 15.3 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Mem_trans PF03547.18 ORX50154.1 - 3e-43 147.7 6.7 4.1e-43 147.2 6.7 1.1 1 0 0 1 1 1 1 Membrane transport protein Dynein_light PF01221.18 ORX50154.1 - 6.1e-29 100.2 0.8 1.1e-28 99.3 0.8 1.4 1 0 0 1 1 1 1 Dynein light chain type 1 Sde2_N_Ubi PF13019.6 ORX50160.1 - 4.2e-24 85.2 0.6 4.7e-24 85.1 0.6 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain ubiquitin PF00240.23 ORX50160.1 - 0.0041 16.8 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family MCR_beta_N PF02783.15 ORX50160.1 - 0.0053 16.4 0.0 0.0068 16.0 0.0 1.2 1 0 0 1 1 1 1 Methyl-coenzyme M reductase beta subunit, N-terminal domain GoLoco PF02188.17 ORX50160.1 - 1.4 8.5 5.1 0.78 9.3 0.8 2.2 2 0 0 2 2 2 0 GoLoco motif NAP PF00956.18 ORX50162.1 - 9.7e-95 316.8 3.9 1.3e-94 316.4 3.9 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) Cwf_Cwc_15 PF04889.12 ORX50162.1 - 2.8 7.6 14.3 1.6 8.4 11.6 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein UBA PF00627.31 ORX50163.1 - 2.8e-24 84.6 3.8 2.9e-13 49.4 0.1 2.6 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 ORX50163.1 - 1.2e-21 76.3 1.3 2.2e-21 75.4 1.3 1.5 1 0 0 1 1 1 1 Ubiquitin family XPC-binding PF09280.11 ORX50163.1 - 2.1e-21 75.4 5.0 7.3e-21 73.7 5.0 1.9 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 ORX50163.1 - 6.3e-10 38.7 1.7 1.3e-09 37.8 1.7 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ORX50163.1 - 0.00045 20.3 0.1 0.00092 19.3 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like CUE PF02845.16 ORX50163.1 - 0.048 13.4 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 CUE domain RepB PF07506.11 ORX50163.1 - 0.075 13.1 0.1 1.7 8.7 0.0 2.6 2 1 0 2 2 2 0 RepB plasmid partitioning protein DUF4168 PF13767.6 ORX50163.1 - 1.8 9.8 7.8 0.7 11.1 3.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4168) Zn_clus PF00172.18 ORX50164.1 - 5.9e-10 39.1 10.4 1e-09 38.3 10.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX50164.1 - 0.0025 16.9 0.0 0.0042 16.1 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4548 PF15081.6 ORX50164.1 - 0.066 13.0 0.2 0.13 12.1 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Zn_clus PF00172.18 ORX50165.1 - 3e-08 33.6 9.2 5.3e-08 32.9 9.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX50165.1 - 0.03 13.4 0.1 0.067 12.2 0.1 1.6 1 0 0 1 1 1 0 Fungal specific transcription factor domain Asp PF00026.23 ORX50166.1 - 2e-87 293.6 12.7 2.4e-87 293.3 12.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX50166.1 - 2.6e-15 57.1 13.2 5e-09 36.7 0.8 4.0 3 2 2 5 5 5 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX50166.1 - 0.00011 22.8 2.1 0.12 13.0 0.3 3.3 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 ORX50166.1 - 0.021 14.6 0.0 0.19 11.5 0.0 2.4 2 1 1 3 3 3 0 Xylanase inhibitor C-terminal OSR1_C PF12202.8 ORX50168.1 - 0.058 13.6 0.1 0.16 12.2 0.1 1.8 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Asp PF00026.23 ORX50169.1 - 1.1e-90 304.2 7.5 1.4e-90 304.0 7.5 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX50169.1 - 4.5e-15 56.3 10.1 1.7e-09 38.2 0.9 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX50169.1 - 1.2e-05 25.9 1.2 0.032 14.8 0.1 3.2 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 ORX50169.1 - 0.011 15.5 0.0 0.17 11.7 0.0 2.7 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX50169.1 - 0.012 16.2 0.1 10 6.7 0.0 3.0 2 2 0 2 2 2 0 gag-polyprotein putative aspartyl protease Asp PF00026.23 ORX50170.1 - 8.3e-92 308.0 13.3 9.8e-92 307.7 13.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX50170.1 - 8.4e-15 55.4 15.1 3.6e-09 37.1 1.1 3.5 2 2 2 4 4 4 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX50170.1 - 6e-06 26.8 1.7 0.0018 18.9 0.1 3.1 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 ORX50170.1 - 0.0023 17.7 0.1 0.022 14.5 0.0 2.6 2 1 1 3 3 3 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX50170.1 - 0.023 15.2 0.6 1.2 9.7 0.0 2.8 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease RhoGAP PF00620.27 ORX50172.1 - 8.9e-33 113.3 0.4 4.8e-32 110.9 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 ORX50172.1 - 5.4e-28 97.0 44.1 2.1e-12 47.1 5.2 5.2 5 0 0 5 5 5 4 LIM domain SF-assemblin PF06705.11 ORX50172.1 - 0.11 11.8 0.8 0.2 10.9 0.8 1.3 1 0 0 1 1 1 0 SF-assemblin/beta giardin ACPS PF01648.20 ORX50173.1 - 4.8e-17 62.1 0.0 5.5e-17 61.9 0.0 1.0 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 ORX50173.1 - 0.049 13.8 0.4 0.47 10.6 0.0 2.5 1 1 1 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain 4HBT_3 PF13622.6 ORX50174.1 - 1.9e-58 198.6 0.0 2.4e-58 198.3 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX50174.1 - 1e-30 106.3 0.0 1e-23 83.6 0.0 2.8 2 1 0 2 2 2 2 Acyl-CoA thioesterase 4HBT PF03061.22 ORX50174.1 - 0.021 15.1 0.1 0.18 12.1 0.0 2.2 2 0 0 2 2 2 0 Thioesterase superfamily FAD-oxidase_C PF02913.19 ORX50175.1 - 3e-64 217.0 0.2 4.2e-64 216.6 0.2 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX50175.1 - 2e-35 121.6 0.0 3.2e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain BTB PF00651.31 ORX50176.1 - 9.1e-20 71.0 0.0 9.1e-15 54.8 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain CAP_GLY PF01302.25 ORX50176.1 - 9.3e-19 67.2 0.0 1.5e-18 66.6 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Fasciclin PF02469.22 ORX50177.1 - 5.4e-67 223.9 2.5 2.5e-18 66.5 0.0 5.2 5 0 0 5 5 5 5 Fasciclin domain CSN8_PSD8_EIF3K PF10075.9 ORX50179.1 - 7.8e-15 55.1 2.1 8.1e-15 55.1 1.0 1.5 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF4250 PF14056.6 ORX50179.1 - 0.062 13.3 0.2 0.32 11.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) PCI PF01399.27 ORX50179.1 - 0.07 13.7 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 PCI domain MFS_1 PF07690.16 ORX50180.1 - 7.6e-05 21.8 33.1 0.0049 15.8 10.6 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily Bac_export_2 PF01312.19 ORX50180.1 - 7.4 5.7 13.0 0.9 8.7 7.9 2.0 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family Lzipper-MIP1 PF14389.6 ORX50181.1 - 0.00029 21.1 14.3 0.33 11.3 1.4 3.8 1 1 2 3 3 3 2 Leucine-zipper of ternary complex factor MIP1 SAT PF16073.5 ORX50181.1 - 0.039 13.7 0.6 0.085 12.6 0.6 1.6 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis ZapB PF06005.12 ORX50181.1 - 0.12 12.8 0.3 0.12 12.8 0.3 2.4 2 0 0 2 2 2 0 Cell division protein ZapB T2SSM PF04612.12 ORX50181.1 - 0.32 11.0 10.1 0.08 13.0 0.9 2.3 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Jnk-SapK_ap_N PF09744.9 ORX50181.1 - 0.33 11.2 14.0 0.57 10.4 14.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 ORX50181.1 - 0.5 10.6 8.2 1 9.5 8.2 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 ORX50181.1 - 5.1 6.6 8.3 8.1 5.9 8.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.8 ORX50181.1 - 5.2 5.8 6.4 8.1 5.2 6.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter VHS PF00790.19 ORX50182.1 - 4.1e-13 49.4 0.3 1.5e-12 47.6 0.2 1.8 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 ORX50182.1 - 6.5e-08 32.8 0.5 1.8e-07 31.4 0.2 1.9 2 0 0 2 2 2 1 GAT domain Ribosomal_S30 PF04758.14 ORX50184.1 - 6.8e-28 96.6 8.7 7.8e-28 96.4 8.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Ribosomal_S3Ae PF01015.18 ORX50185.1 - 6.1e-74 248.0 4.7 7.1e-74 247.8 4.7 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family Med3 PF11593.8 ORX50185.1 - 0.005 16.1 0.1 0.0081 15.4 0.1 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Caudo_TAP PF02413.17 ORX50185.1 - 0.056 13.6 1.6 3.1 7.9 1.0 2.3 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK TipAS PF07739.13 ORX50185.1 - 0.083 13.4 0.2 0.84 10.2 0.0 2.3 1 1 1 2 2 2 0 TipAS antibiotic-recognition domain SUI1 PF01253.22 ORX50185.1 - 0.09 13.3 0.9 2 9.0 0.1 2.4 2 0 0 2 2 2 0 Translation initiation factor SUI1 Sec5 PF15469.6 ORX50186.1 - 2e-53 181.1 3.9 2e-53 181.1 3.9 3.1 3 1 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.11 ORX50186.1 - 1e-06 28.7 0.3 1e-06 28.7 0.3 3.4 5 0 0 5 5 5 1 Vps51/Vps67 DUF4047 PF13256.6 ORX50186.1 - 0.013 15.7 3.4 0.052 13.7 0.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4047) DUF3961 PF13106.6 ORX50186.1 - 0.017 14.8 0.1 0.035 13.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) Lge1 PF11488.8 ORX50186.1 - 0.036 14.3 0.4 0.28 11.4 0.4 2.6 1 0 0 1 1 1 0 Transcriptional regulatory protein LGE1 COG5 PF10392.9 ORX50186.1 - 0.061 13.5 1.5 0.28 11.4 0.8 2.5 2 0 0 2 2 2 0 Golgi transport complex subunit 5 Pam16 PF03656.13 ORX50186.1 - 0.098 12.7 0.0 0.28 11.2 0.0 1.8 1 0 0 1 1 1 0 Pam16 ApoLp-III PF07464.11 ORX50186.1 - 0.23 11.6 2.5 0.37 10.9 0.2 2.6 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) CENP-H PF05837.12 ORX50186.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.2 3 1 0 3 3 3 0 Centromere protein H (CENP-H) DUF2752 PF10825.8 ORX50188.1 - 0.081 13.0 0.7 2.4 8.3 0.0 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2752) Actin PF00022.19 ORX50190.1 - 9.8e-132 439.4 0.0 4.4e-131 437.2 0.0 1.7 1 1 0 1 1 1 1 Actin CDT1 PF08839.11 ORX50191.1 - 2e-08 34.8 0.1 2e-08 34.8 0.1 2.1 2 1 0 2 2 2 1 DNA replication factor CDT1 like DUF4097 PF13349.6 ORX50192.1 - 5.4e-09 35.8 3.4 1.1e-08 34.8 3.4 1.5 1 1 0 1 1 1 1 Putative adhesin DEAD PF00270.29 ORX50193.1 - 2.5e-49 167.4 0.0 5.5e-49 166.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX50193.1 - 1.6e-24 86.4 0.1 3.1e-23 82.2 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 ORX50193.1 - 2.7e-21 75.6 2.2 2.7e-21 75.6 2.2 3.3 3 0 0 3 3 3 1 DBP10CT (NUC160) domain RhoGAP PF00620.27 ORX50194.1 - 2.8e-47 160.3 0.0 1.2e-46 158.3 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 ORX50194.1 - 6.8e-15 55.1 0.2 6.8e-15 55.1 0.2 2.2 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain LRS4 PF10422.9 ORX50194.1 - 0.026 14.1 2.5 0.048 13.2 2.2 1.6 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 Acetyltransf_11 PF13720.6 ORX50194.1 - 0.041 14.4 0.0 0.14 12.7 0.0 2.0 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Methyltransf_25 PF13649.6 ORX50195.1 - 5.3e-12 46.3 0.0 9.9e-12 45.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX50195.1 - 9.5e-11 41.8 0.0 1.2e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX50195.1 - 5.5e-09 36.0 0.1 2.8e-06 27.2 0.1 2.1 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.17 ORX50195.1 - 2.3e-08 33.7 0.2 2.8e-07 30.2 0.2 2.3 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_11 PF08241.12 ORX50195.1 - 2.8e-07 31.1 0.0 5.3e-07 30.2 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX50195.1 - 4.5e-07 30.5 0.0 1.9e-06 28.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX50195.1 - 9.4e-05 22.0 0.0 0.0002 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ORX50195.1 - 0.00023 20.6 0.0 0.0004 19.8 0.0 1.3 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX50195.1 - 0.00043 20.4 0.0 0.00089 19.4 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase GidB PF02527.15 ORX50195.1 - 0.0006 19.2 0.0 0.0059 16.0 0.0 2.0 1 1 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_9 PF08003.11 ORX50195.1 - 0.0022 17.0 0.0 0.0032 16.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MetW PF07021.12 ORX50195.1 - 0.0026 17.4 0.0 0.0033 17.0 0.0 1.1 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 ORX50195.1 - 0.0027 17.0 0.0 0.017 14.4 0.0 1.8 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.18 ORX50195.1 - 0.033 13.5 0.0 0.033 13.5 0.0 1.2 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_17 PF12692.7 ORX50195.1 - 0.049 13.6 0.0 0.059 13.4 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl-L-methionine methyltransferase Methyltransf_15 PF09445.10 ORX50195.1 - 0.1 12.2 0.0 0.25 10.9 0.0 1.6 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_29 PF03141.16 ORX50195.1 - 0.12 10.9 0.0 5.2 5.5 0.0 2.0 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Peptidase_C1 PF00112.23 ORX50197.1 - 2.1e-56 191.5 0.0 2.4e-56 191.2 0.0 1.0 1 0 0 1 1 1 1 Papain family cysteine protease F-box-like PF12937.7 ORX50200.1 - 0.00018 21.3 0.6 0.00033 20.5 0.6 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX50200.1 - 0.002 17.9 0.7 0.0055 16.5 0.7 1.8 1 0 0 1 1 1 1 F-box domain DEAD PF00270.29 ORX50201.1 - 1.6e-42 145.2 0.3 2.8e-42 144.5 0.3 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX50201.1 - 8.3e-30 103.4 0.1 6.5e-28 97.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX50201.1 - 4.7e-07 30.0 0.0 1.4e-06 28.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX50201.1 - 0.013 15.8 0.1 0.035 14.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 ORX50202.1 - 3e-45 154.1 0.7 7.7e-44 149.5 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX50202.1 - 4.9e-23 81.6 1.2 5.4e-22 78.2 0.2 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX50202.1 - 1.8e-08 34.6 0.0 3.5e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX50202.1 - 0.00083 18.9 0.3 0.067 12.6 0.1 2.9 3 0 0 3 3 3 1 PhoH-like protein AAA_30 PF13604.6 ORX50202.1 - 0.0066 16.2 0.0 0.014 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ORX50202.1 - 0.091 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Helicase AAA_22 PF13401.6 ORX50202.1 - 0.11 12.8 0.2 0.43 10.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain GLTSCR1 PF15249.6 ORX50203.1 - 1.8e-14 54.0 0.8 1.8e-14 54.0 0.8 3.8 4 1 1 5 5 5 1 Conserved region of unknown function on GLTSCR protein DUF2263 PF10021.9 ORX50203.1 - 1.2 9.5 7.7 0.19 12.1 0.6 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2263) ALMT PF11744.8 ORX50203.1 - 6.4 5.5 11.9 5.6 5.7 3.9 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter SNase PF00565.17 ORX50204.1 - 8.3e-20 71.3 0.1 1.3e-19 70.7 0.1 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Glyco_tranf_2_3 PF13641.6 ORX50205.1 - 3.2e-26 92.6 0.2 4.3e-26 92.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ORX50205.1 - 1.4e-09 37.7 0.5 2.3e-08 33.7 0.5 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX50205.1 - 3.3e-08 33.5 0.0 5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 PTSIIB_sorb PF03830.15 ORX50205.1 - 0.04 14.1 0.0 0.068 13.4 0.0 1.3 1 0 0 1 1 1 0 PTS system sorbose subfamily IIB component Chitin_synth_2 PF03142.15 ORX50205.1 - 1.7 7.1 6.8 6.8 5.2 6.8 1.8 1 1 0 1 1 1 0 Chitin synthase CAF1 PF04857.20 ORX50206.1 - 3.1e-52 177.7 0.4 4.9e-25 88.4 0.1 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease Torus PF16131.5 ORX50206.1 - 0.0063 17.2 0.6 0.014 16.1 0.6 1.5 1 0 0 1 1 1 1 Torus domain DNA_pol_A_exo1 PF01612.20 ORX50206.1 - 0.026 14.2 0.1 12 5.5 0.0 2.9 3 0 0 3 3 3 0 3'-5' exonuclease zf-CCCH PF00642.24 ORX50206.1 - 0.14 12.1 0.7 0.3 11.1 0.7 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX50206.1 - 0.67 10.1 2.6 1.5 9.0 2.6 1.6 1 0 0 1 1 1 0 Zinc finger domain OrfB_Zn_ribbon PF07282.11 ORX50207.1 - 2.2e-10 40.3 3.9 7.8e-10 38.5 1.2 2.4 2 0 0 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX50207.1 - 0.63 10.1 4.4 1.3 9.1 4.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 ORX50208.1 - 2.6e-15 56.3 9.4 2.6e-15 56.3 9.4 2.1 2 0 0 2 2 2 1 FYVE zinc finger DiS_P_DiS PF06750.13 ORX50208.1 - 0.29 11.3 2.6 1.4 9.0 0.7 2.6 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain WD40 PF00400.32 ORX50209.1 - 5.2e-12 46.1 5.2 5e-06 27.2 0.1 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat Filament PF00038.21 ORX50210.1 - 0.00048 19.8 1.6 0.00063 19.4 1.6 1.1 1 0 0 1 1 1 1 Intermediate filament protein Med21 PF11221.8 ORX50210.1 - 0.0049 17.1 3.5 0.0073 16.6 3.5 1.3 1 0 0 1 1 1 1 Subunit 21 of Mediator complex FOXP-CC PF16159.5 ORX50210.1 - 0.0051 17.4 1.4 0.044 14.4 0.5 2.3 1 1 1 2 2 2 1 FOXP coiled-coil domain Laminin_I PF06008.14 ORX50210.1 - 0.0053 16.5 1.0 0.0065 16.2 1.0 1.1 1 0 0 1 1 1 1 Laminin Domain I Dor1 PF04124.12 ORX50210.1 - 0.0061 15.3 1.5 0.011 14.4 1.6 1.4 1 1 0 1 1 1 1 Dor1-like family GAS PF13851.6 ORX50210.1 - 0.0067 15.8 4.7 0.0087 15.4 4.7 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding PilO PF04350.13 ORX50210.1 - 0.0075 16.4 0.7 0.0096 16.1 0.7 1.3 1 0 0 1 1 1 1 Pilus assembly protein, PilO V-SNARE PF05008.15 ORX50210.1 - 0.0076 16.6 2.9 0.31 11.4 0.5 2.3 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus Seryl_tRNA_N PF02403.22 ORX50210.1 - 0.025 14.8 0.6 0.1 12.8 0.0 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HMMR_N PF15905.5 ORX50210.1 - 0.029 13.9 2.7 0.035 13.6 2.7 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FPP PF05911.11 ORX50210.1 - 0.032 12.4 1.9 0.037 12.2 1.9 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil CemA PF03040.14 ORX50210.1 - 0.035 14.1 0.3 0.059 13.3 0.2 1.4 1 1 0 1 1 1 0 CemA family ERO1 PF04137.15 ORX50210.1 - 0.036 13.3 0.6 0.042 13.0 0.6 1.0 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) DUF4795 PF16043.5 ORX50210.1 - 0.037 13.6 1.7 0.051 13.2 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4404 PF14357.6 ORX50210.1 - 0.037 14.6 3.1 0.1 13.3 1.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) PspA_IM30 PF04012.12 ORX50210.1 - 0.038 13.6 0.5 0.5 9.9 0.2 1.9 1 1 1 2 2 2 0 PspA/IM30 family OmpH PF03938.14 ORX50210.1 - 0.049 14.0 2.4 0.069 13.5 2.4 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Phage_HK97_TLTM PF06120.11 ORX50210.1 - 0.053 12.7 0.5 0.063 12.5 0.5 1.1 1 0 0 1 1 1 0 Tail length tape measure protein Prefoldin_2 PF01920.20 ORX50210.1 - 0.055 13.4 0.2 0.055 13.4 0.2 2.3 1 1 0 2 2 2 0 Prefoldin subunit DUF2207 PF09972.9 ORX50210.1 - 0.084 11.6 0.0 0.092 11.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tropomyosin_1 PF12718.7 ORX50210.1 - 0.096 12.8 1.8 0.13 12.5 1.4 1.4 1 1 0 1 1 1 0 Tropomyosin like LXG PF04740.12 ORX50210.1 - 0.11 12.2 2.0 0.37 10.5 2.0 1.7 1 1 0 1 1 1 0 LXG domain of WXG superfamily PMC2NT PF08066.12 ORX50210.1 - 0.12 13.1 0.4 4 8.2 0.3 2.2 1 1 1 2 2 2 0 PMC2NT (NUC016) domain Glyco_trans_1_2 PF13524.6 ORX50210.1 - 0.12 12.8 0.4 2.1 8.8 0.0 2.2 1 1 1 2 2 2 0 Glycosyl transferases group 1 Syntaxin_2 PF14523.6 ORX50210.1 - 0.19 12.1 3.6 1.5 9.2 3.6 2.2 1 1 0 1 1 1 0 Syntaxin-like protein TMPIT PF07851.13 ORX50210.1 - 0.43 9.8 4.6 0.69 9.1 4.6 1.5 1 1 0 1 1 1 0 TMPIT-like protein ING PF12998.7 ORX50210.1 - 0.47 11.1 5.4 6.9 7.3 5.4 2.1 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding UPF0242 PF06785.11 ORX50210.1 - 1.5 8.9 8.2 5.1 7.1 8.2 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Tup_N PF08581.10 ORX50210.1 - 1.8 8.9 8.1 1.9 8.9 6.1 2.0 1 1 1 2 2 2 0 Tup N-terminal Dishevelled PF02377.15 ORX50211.1 - 0.013 15.9 0.1 0.017 15.6 0.1 1.2 1 0 0 1 1 1 0 Dishevelled specific domain Pex26 PF07163.12 ORX50212.1 - 7.8e-07 28.7 1.5 7.8e-07 28.7 1.5 2.6 1 1 2 3 3 3 1 Pex26 protein ERM PF00769.19 ORX50212.1 - 0.0021 17.9 16.7 0.0029 17.5 16.7 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Spt20 PF12090.8 ORX50212.1 - 0.04 13.5 7.1 0.071 12.7 7.1 1.3 1 0 0 1 1 1 0 Spt20 family Rotamase_2 PF13145.6 ORX50212.1 - 0.094 13.6 17.5 0.32 11.8 17.5 1.8 1 1 0 1 1 1 0 PPIC-type PPIASE domain EMC3_TMCO1 PF01956.16 ORX50212.1 - 0.18 11.5 1.8 0.32 10.7 1.8 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like LMBR1 PF04791.16 ORX50212.1 - 0.22 10.4 2.2 0.28 10.0 2.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Borrelia_P83 PF05262.11 ORX50212.1 - 0.35 9.3 13.3 0.43 9.0 13.3 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein V_ATPase_I PF01496.19 ORX50212.1 - 0.81 7.5 6.1 0.97 7.3 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2151 PF10221.9 ORX50212.1 - 0.93 8.0 7.9 1.2 7.6 7.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator SprA-related PF12118.8 ORX50212.1 - 1.2 8.2 19.9 1.7 7.7 19.9 1.2 1 0 0 1 1 1 0 SprA-related family DUF4407 PF14362.6 ORX50212.1 - 3.4 7.0 14.4 5.5 6.2 14.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RR_TM4-6 PF06459.12 ORX50212.1 - 4 7.2 14.0 6.4 6.5 14.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 VIT1 PF01988.19 ORX50212.1 - 4 7.2 9.9 10 5.9 9.9 1.6 1 1 0 1 1 1 0 VIT family Sec62 PF03839.16 ORX50212.1 - 5.2 6.5 7.8 8.1 5.9 7.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4569 PF15133.6 ORX50212.1 - 5.6 6.6 13.6 8.6 6.0 13.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF1664 PF07889.12 ORX50213.1 - 0.33 11.0 2.7 1.1 9.4 2.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) LOH1CR12 PF10158.9 ORX50213.1 - 0.59 10.1 7.0 0.25 11.3 4.9 1.5 2 0 0 2 2 2 0 Tumour suppressor protein CN_hydrolase PF00795.22 ORX50214.1 - 1.1e-27 97.1 0.0 1.4e-27 96.7 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Med5 PF08689.10 ORX50217.1 - 6.2e-21 74.0 0.1 1.1e-20 73.2 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit Med5 Med24_N PF11277.8 ORX50217.1 - 1.3e-05 23.5 2.1 0.099 10.7 0.0 4.2 4 0 0 4 4 4 3 Mediator complex subunit 24 N-terminal AMP-binding PF00501.28 ORX50218.1 - 6.6e-94 314.9 0.0 8.6e-94 314.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme p450 PF00067.22 ORX50219.1 - 5.1e-74 249.7 0.1 6.2e-74 249.4 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF953 PF06110.11 ORX50219.1 - 0.16 11.6 0.0 0.42 10.2 0.0 1.7 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) Bromo_TP PF07524.13 ORX50220.1 - 2.3e-14 53.1 0.0 2.6e-14 53.0 0.0 1.0 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 ORX50220.1 - 0.16 12.1 0.0 0.16 12.1 0.0 1.2 1 1 0 1 1 1 0 Histone-fold protein MFS_1 PF07690.16 ORX50221.1 - 3.6e-38 131.4 31.6 5.6e-38 130.8 31.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ORX50221.1 - 0.013 14.4 9.7 0.2 10.5 1.5 2.3 2 0 0 2 2 2 0 MFS_1 like family DUF2897 PF11446.8 ORX50221.1 - 4.6 7.2 6.1 0.95 9.4 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) Aminotran_1_2 PF00155.21 ORX50222.1 - 1.5e-62 211.9 0.0 1.8e-62 211.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX50222.1 - 0.056 12.0 0.1 0.12 10.9 0.0 1.5 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Alliinase_C PF04864.13 ORX50222.1 - 0.1 11.4 0.0 0.26 10.1 0.0 1.6 2 0 0 2 2 2 0 Allinase BLOC1_2 PF10046.9 ORX50223.1 - 6.9e-26 90.4 5.7 8.5e-26 90.1 5.7 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1241 PF06840.11 ORX50223.1 - 0.00061 19.5 1.4 0.0007 19.3 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) DUF4200 PF13863.6 ORX50223.1 - 0.0047 17.3 9.0 0.0089 16.4 9.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4200) Med9 PF07544.13 ORX50223.1 - 0.006 16.6 1.4 0.012 15.7 1.4 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 DUF3829 PF12889.7 ORX50223.1 - 0.0088 15.6 3.4 0.012 15.2 3.4 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3829) T3SSipB PF16535.5 ORX50223.1 - 0.01 16.3 2.3 0.011 16.2 1.7 1.5 1 1 0 1 1 1 0 Type III cell invasion protein SipB Phg_2220_C PF09524.10 ORX50223.1 - 0.013 15.6 0.7 0.035 14.2 0.2 1.9 2 0 0 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) CDH1_2_SANT_HL1 PF18375.1 ORX50223.1 - 0.015 16.0 0.5 0.04 14.6 0.1 1.8 1 1 1 2 2 2 0 CDH1/2 SANT-Helical linker 1 MCPsignal PF00015.21 ORX50223.1 - 0.016 15.1 0.9 0.019 14.8 0.9 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain eIF3_subunit PF08597.10 ORX50223.1 - 0.019 14.9 4.5 0.023 14.6 4.5 1.3 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF1708 PF08101.11 ORX50223.1 - 0.02 14.1 2.0 0.022 14.0 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) GCN5L1 PF06320.13 ORX50223.1 - 0.047 13.8 4.2 0.061 13.5 4.2 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) ING PF12998.7 ORX50223.1 - 0.055 14.1 5.4 0.041 14.5 3.8 1.6 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding T2SSF PF00482.23 ORX50223.1 - 0.083 12.8 1.7 0.23 11.4 1.7 1.8 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF3958 PF13125.6 ORX50223.1 - 0.11 12.7 7.0 0.1 12.8 5.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) DUF1664 PF07889.12 ORX50223.1 - 0.12 12.4 2.6 0.23 11.5 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) LOH1CR12 PF10158.9 ORX50223.1 - 0.18 11.8 5.4 0.28 11.2 5.4 1.5 1 1 0 1 1 1 0 Tumour suppressor protein TMPIT PF07851.13 ORX50223.1 - 0.21 10.8 5.3 0.27 10.5 5.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein Fib_alpha PF08702.10 ORX50223.1 - 0.28 11.4 6.3 0.21 11.8 3.9 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FapA PF03961.13 ORX50223.1 - 0.49 8.9 3.9 0.57 8.7 3.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 ORX50223.1 - 0.9 9.1 6.8 0.89 9.1 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Aminotran_3 PF00202.21 ORX50224.1 - 1.6e-117 392.6 0.0 2e-117 392.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ORX50224.1 - 7.1e-05 22.1 0.0 0.00012 21.4 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class I and II Use1 PF09753.9 ORX50225.1 - 1.3e-31 110.2 6.3 2.5e-31 109.3 6.3 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 Neur_chan_memb PF02932.16 ORX50225.1 - 0.037 14.1 3.9 0.063 13.3 3.6 1.5 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2895 PF11444.8 ORX50225.1 - 0.045 13.1 1.1 0.14 11.6 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) Homez PF11569.8 ORX50225.1 - 0.062 12.8 6.9 0.062 12.8 0.4 2.9 3 0 0 3 3 3 0 Homeodomain leucine-zipper encoding, Homez DUF3323 PF11796.8 ORX50225.1 - 0.068 13.1 1.0 1.2 8.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) Ycf70 PF17382.2 ORX50225.1 - 0.11 12.9 0.2 0.41 11.1 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized Ycf70-like APG6_N PF17675.1 ORX50225.1 - 0.13 12.8 18.4 0.035 14.6 6.1 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region SF3A3 PF16837.5 ORX50225.1 - 0.14 12.7 0.9 0.63 10.6 0.9 2.1 1 1 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Exonuc_VII_L PF02601.15 ORX50225.1 - 0.79 9.2 10.6 1.3 8.5 1.0 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit Fzo_mitofusin PF04799.13 ORX50225.1 - 2.6 7.6 7.7 6 6.4 0.1 2.2 2 0 0 2 2 2 0 fzo-like conserved region RmuC PF02646.16 ORX50225.1 - 2.8 7.0 9.6 1.7 7.7 0.8 2.7 2 1 0 2 2 2 0 RmuC family Hpt PF01627.23 ORX50226.1 - 1e-11 44.9 0.0 1.5e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 Hpt domain MMR_HSR1_Xtn PF16897.5 ORX50227.1 - 9.2e-45 151.0 1.5 8.8e-44 147.9 0.9 2.2 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ORX50227.1 - 2.5e-21 75.9 0.2 7.3e-21 74.4 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 ORX50227.1 - 3.4e-19 68.7 0.1 6.2e-19 67.8 0.1 1.5 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 ORX50227.1 - 5.9e-12 45.4 0.1 3.3e-11 43.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 ORX50227.1 - 0.0022 17.0 1.3 0.0053 15.8 0.4 2.0 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ORX50227.1 - 0.0038 17.3 0.3 1.2 9.1 0.0 2.6 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 ORX50227.1 - 0.028 14.0 0.4 12 5.4 0.0 3.5 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX50227.1 - 0.33 10.8 2.4 6 6.7 0.1 3.0 2 1 1 3 3 3 0 RsgA GTPase DEAD PF00270.29 ORX50228.1 - 4.5e-43 147.0 0.7 9.8e-43 145.9 0.7 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX50228.1 - 1.1e-27 96.6 0.8 4.2e-26 91.5 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX50228.1 - 1.1e-05 25.5 0.0 1.1e-05 25.5 0.0 2.6 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX50228.1 - 0.026 14.8 2.1 0.2 11.9 2.1 2.4 1 1 0 1 1 1 0 AAA domain EI24 PF07264.11 ORX50229.1 - 3.2e-20 73.1 7.7 4e-20 72.8 7.7 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) DUF4134 PF13572.6 ORX50229.1 - 0.014 15.6 0.7 0.044 14.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4134) SNF5 PF04855.12 ORX50230.1 - 0.00081 19.2 0.9 0.0011 18.9 0.9 1.2 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 DUF4378 PF14309.6 ORX50230.1 - 0.045 14.1 0.1 0.52 10.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4378) Cyt-b5 PF00173.28 ORX50231.1 - 6.6e-09 35.8 0.1 7e-09 35.7 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain PIP5K PF01504.18 ORX50232.1 - 2.3e-34 118.9 2.6 5e-34 117.8 2.6 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 ORX50232.1 - 7.1e-26 90.9 0.0 1.2e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 ORX50232.1 - 4.6e-16 58.7 15.2 4.6e-16 58.7 15.2 2.0 2 0 0 2 2 2 1 FYVE zinc finger XPC-binding PF09280.11 ORX50232.1 - 0.88 9.4 5.2 0.87 9.4 0.1 3.1 2 0 0 2 2 2 0 XPC-binding domain zf-AD PF07776.15 ORX50232.1 - 1.4 9.2 7.3 0.6 10.4 2.5 3.0 2 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) THP2 PF09432.10 ORX50233.1 - 0.0059 16.6 0.6 0.029 14.4 0.3 1.9 1 1 1 2 2 2 1 Tho complex subunit THP2 Brr6_like_C_C PF10104.9 ORX50233.1 - 0.048 13.4 0.3 2.2 8.0 0.0 2.4 1 1 1 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain QIL1 PF15884.5 ORX50233.1 - 0.086 13.5 0.0 0.16 12.5 0.0 1.4 1 0 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 Z1 PF10593.9 ORX50233.1 - 0.1 12.1 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 Z1 domain Sulfatase PF00884.23 ORX50234.1 - 2.3e-66 224.3 2.7 3.6e-66 223.7 2.7 1.3 1 0 0 1 1 1 1 Sulfatase DUF229 PF02995.17 ORX50234.1 - 5e-05 22.1 0.0 7.5e-05 21.5 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF229) DUF4976 PF16347.5 ORX50234.1 - 0.0019 18.5 0.0 0.005 17.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 ORX50234.1 - 0.0024 17.5 3.6 0.028 14.0 3.6 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 ORX50234.1 - 0.071 12.2 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Ribosom_S12_S23 PF00164.25 ORX50235.1 - 1.7e-37 127.5 1.7 2.2e-37 127.2 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 AAA_16 PF13191.6 ORX50236.1 - 5.2e-07 30.2 0.0 1.4e-05 25.5 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX50236.1 - 0.0016 18.8 2.2 0.54 10.5 0.0 3.3 3 0 0 3 3 3 2 AAA domain Guanylate_cyc PF00211.20 ORX50236.1 - 0.0059 16.2 0.0 0.027 14.1 0.0 2.1 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain RNA_helicase PF00910.22 ORX50236.1 - 0.14 12.5 0.1 0.89 10.0 0.0 2.5 2 0 0 2 2 2 0 RNA helicase DUF2075 PF09848.9 ORX50236.1 - 0.16 11.2 0.0 0.57 9.4 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) TPR_2 PF07719.17 ORX50236.1 - 1.1 9.6 4.7 14 6.1 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat RabGAP-TBC PF00566.18 ORX50238.1 - 4.5e-34 118.0 0.2 4.5e-34 118.0 0.2 2.9 3 0 0 3 3 3 1 Rab-GTPase-TBC domain SBE2 PF17076.5 ORX50238.1 - 0.011 13.9 5.9 0.024 12.9 5.9 1.4 1 0 0 1 1 1 0 SBE2, cell-wall formation Pkinase PF00069.25 ORX50239.1 - 2e-43 148.7 0.0 1.1e-31 110.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 ORX50239.1 - 2.7e-42 143.9 0.1 5.5e-42 142.9 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 ORX50239.1 - 3.1e-21 75.8 0.0 7.5e-20 71.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ_3 PF13570.6 ORX50239.1 - 4.2e-06 27.1 0.1 0.027 15.0 0.0 3.6 3 0 0 3 3 3 2 PQQ-like domain PQQ PF01011.21 ORX50239.1 - 6.4e-05 22.7 2.8 1.9 8.6 0.0 4.8 4 0 0 4 4 4 2 PQQ enzyme repeat Kdo PF06293.14 ORX50239.1 - 0.00087 18.7 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PQQ_2 PF13360.6 ORX50239.1 - 0.0018 17.9 0.0 0.058 13.0 0.0 2.8 2 1 1 3 3 3 1 PQQ-like domain Barttin PF15462.6 ORX50239.1 - 0.0025 17.6 2.5 0.0054 16.5 2.5 1.5 1 0 0 1 1 1 1 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Pkinase_fungal PF17667.1 ORX50239.1 - 0.0077 15.0 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Nodulin_late PF07127.11 ORX50239.1 - 0.018 15.4 0.1 0.041 14.2 0.1 1.5 1 0 0 1 1 1 0 Late nodulin protein FTA2 PF13095.6 ORX50239.1 - 0.058 13.0 0.2 1.6 8.3 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Transcrip_reg PF01709.20 ORX50240.1 - 3.6e-78 262.3 8.2 4.1e-78 262.1 8.2 1.0 1 0 0 1 1 1 1 Transcriptional regulator Phage_TAC_12 PF12363.8 ORX50240.1 - 0.064 13.7 0.8 0.38 11.2 0.1 2.5 3 0 0 3 3 3 0 Phage tail assembly chaperone protein, TAC FIVAR PF07554.13 ORX50240.1 - 4.7 8.1 8.7 3.4 8.5 2.3 3.0 3 0 0 3 3 3 0 FIVAR domain Cyclin PF08613.11 ORX50241.1 - 2.1e-07 31.4 0.2 3.6e-07 30.7 0.2 1.5 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX50241.1 - 0.002 17.9 0.3 0.0035 17.1 0.3 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain V-set_2 PF15910.5 ORX50241.1 - 0.075 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 ICOS V-set domain TB2_DP1_HVA22 PF03134.19 ORX50242.1 - 3.9e-16 58.8 1.5 6.8e-16 58.0 1.5 1.4 1 0 0 1 1 1 1 TB2/DP1, HVA22 family SMC_N PF02463.19 ORX50243.1 - 2.5e-63 213.4 17.5 1.4e-62 211.0 17.5 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX50243.1 - 1.6e-27 96.1 0.0 5.1e-27 94.5 0.0 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX50243.1 - 3.3e-15 56.7 1.1 1.3e-06 28.5 0.2 3.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ORX50243.1 - 6.6e-08 32.6 60.6 0.00017 21.4 30.8 4.3 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 ORX50243.1 - 0.0024 18.4 53.8 0.0024 18.4 53.8 6.4 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.6 ORX50243.1 - 0.025 14.3 0.0 0.058 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ORX50243.1 - 0.036 14.6 0.1 0.34 11.4 0.0 6.2 4 2 2 6 6 6 0 ABC transporter FtsK_SpoIIIE PF01580.18 ORX50243.1 - 0.5 9.7 0.0 0.5 9.7 0.0 3.9 4 1 0 4 4 4 0 FtsK/SpoIIIE family Septin PF00735.18 ORX50245.1 - 4e-28 98.5 2.3 2.1e-25 89.5 0.3 2.9 2 1 0 2 2 2 2 Septin Dynamin_N PF00350.23 ORX50245.1 - 0.011 15.8 0.6 4.4 7.3 0.0 2.7 3 0 0 3 3 3 0 Dynamin family RsgA_GTPase PF03193.16 ORX50245.1 - 0.014 15.3 0.0 0.74 9.7 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase AAA_23 PF13476.6 ORX50245.1 - 0.07 13.6 1.1 1.6 9.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX50245.1 - 0.078 12.7 0.0 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ORX50245.1 - 0.12 12.4 0.0 1.6 8.9 0.0 2.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ORX50245.1 - 0.13 12.6 2.6 0.58 10.4 0.0 3.0 3 1 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 ORX50245.1 - 0.17 11.6 0.1 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ORX50245.1 - 0.17 12.3 0.9 0.67 10.3 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain MUG113 PF13455.6 ORX50245.1 - 1.6 9.5 5.0 3.9 8.2 2.3 2.5 2 0 0 2 2 2 0 Meiotically up-regulated gene 113 SCP2 PF02036.17 ORX50430.1 - 0.03 14.8 0.0 0.036 14.5 0.0 1.1 1 0 0 1 1 1 0 SCP-2 sterol transfer family Cullin PF00888.22 ORX50431.1 - 1.1e-17 64.0 0.3 1.1e-17 64.0 0.3 1.7 2 0 0 2 2 2 1 Cullin family AMP-binding PF00501.28 ORX50432.1 - 3.5e-100 335.6 0.0 4.8e-100 335.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX50432.1 - 3.8e-13 50.2 0.3 1.1e-12 48.8 0.3 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain TrkA_N PF02254.18 ORX50432.1 - 0.025 14.8 0.1 3.1 8.1 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain GLTSCR1 PF15249.6 ORX50432.1 - 0.12 12.9 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein ArAE_2 PF10334.9 ORX50433.1 - 2.5e-18 66.7 0.2 4.2e-18 66.0 0.2 1.3 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 ORX50433.1 - 3.4e-15 56.3 13.9 9.8e-15 54.8 13.9 1.7 1 0 0 1 1 1 1 Fusaric acid resistance protein-like ArAE_2_N PF10337.9 ORX50433.1 - 2.2e-08 33.6 0.6 0.00011 21.4 0.0 3.2 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC PF04632.12 ORX50433.1 - 0.00012 20.7 15.2 0.00031 19.4 14.3 2.0 1 1 1 2 2 2 1 Fusaric acid resistance protein family ALMT PF11744.8 ORX50433.1 - 0.00058 18.8 0.2 0.001 18.0 0.2 1.3 1 0 0 1 1 1 1 Aluminium activated malate transporter ArAE_2_N PF10337.9 ORX50434.1 - 0.0064 15.6 1.0 1.5 7.7 0.0 2.0 1 1 1 2 2 2 2 Putative ER transporter, 6TM, N-terminal CPP1-like PF11833.8 ORX50434.1 - 0.064 12.9 3.6 0.073 12.7 3.6 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3810 PF12725.7 ORX50434.1 - 1.1 8.6 3.0 6.1 6.1 3.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) ArAE_2 PF10334.9 ORX50435.1 - 1e-14 54.9 0.3 1.3e-14 54.6 0.3 1.1 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ORX50436.1 - 1.9e-11 43.7 0.3 1.9e-11 43.7 0.3 2.3 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal AMP-binding PF00501.28 ORX50437.1 - 1.4e-91 307.2 0.0 1.7e-91 306.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX50437.1 - 4.5e-15 56.4 0.0 9.9e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Pga1 PF10333.9 ORX50438.1 - 0.068 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 GPI-Mannosyltransferase II co-activator CENP-K PF11802.8 ORX50440.1 - 2.3e-20 73.3 9.3 8.3e-20 71.5 9.3 1.6 1 1 0 1 1 1 1 Centromere-associated protein K PSK_trans_fac PF07704.11 ORX50440.1 - 0.0011 19.6 3.6 0.0049 17.6 0.1 3.0 3 0 0 3 3 3 1 Rv0623-like transcription factor SpoIIID PF12116.8 ORX50440.1 - 0.032 14.3 0.5 0.1 12.7 0.2 2.0 2 0 0 2 2 2 0 Stage III sporulation protein D DUF5345 PF17280.2 ORX50440.1 - 0.048 13.6 0.1 0.16 12.0 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5345) BBS2_C PF14782.6 ORX50440.1 - 0.55 8.9 7.9 2 7.1 0.4 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal TAFII55_N PF04658.13 ORX50441.1 - 3.7e-52 176.3 5.8 7.4e-52 175.3 0.2 2.3 2 0 0 2 2 2 1 TAFII55 protein conserved region Nop14 PF04147.12 ORX50441.1 - 0.95 7.6 27.6 1.4 7.0 27.6 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ORX50441.1 - 2 7.7 27.0 0.14 11.5 21.3 1.9 2 0 0 2 2 2 0 BUD22 NOA36 PF06524.12 ORX50441.1 - 2.2 7.5 20.7 3.7 6.8 20.7 1.5 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ORX50441.1 - 2.7 6.2 17.1 3.5 5.8 17.1 1.3 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ORX50441.1 - 2.9 7.2 29.3 0.26 10.7 24.5 1.6 2 0 0 2 2 2 0 SDA1 SURF2 PF05477.11 ORX50441.1 - 4.6 6.9 14.1 9.3 5.9 14.1 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Drc1-Sld2 PF11719.8 ORX50441.1 - 7.2 6.0 16.6 0.12 11.9 8.5 1.9 2 0 0 2 2 2 0 DNA replication and checkpoint protein HEAT PF02985.22 ORX50442.1 - 3.3e-10 39.3 1.1 0.46 10.9 0.0 6.4 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 ORX50442.1 - 9.8e-08 32.3 0.3 0.00011 22.5 0.0 5.3 4 2 1 5 5 5 1 HEAT repeats Cnd1 PF12717.7 ORX50442.1 - 1.1e-06 28.8 0.2 0.36 10.9 0.0 5.6 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ORX50442.1 - 7.1e-05 23.2 3.9 0.37 11.4 0.0 5.4 5 1 0 5 5 5 2 HEAT-like repeat bVLRF1 PF18826.1 ORX50443.1 - 8.5e-63 210.7 0.1 1.2e-61 206.9 0.2 2.5 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 ORX50443.1 - 7.9e-07 29.2 0.0 2.2e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX50443.1 - 0.0027 18.3 0.0 0.0081 16.7 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX50443.1 - 0.012 16.1 0.4 0.033 14.6 0.4 1.8 1 0 0 1 1 1 0 Ankyrin repeat DUF3772 PF12607.8 ORX50443.1 - 0.038 13.7 0.3 0.2 11.4 0.3 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) zf_CCCH_4 PF18345.1 ORX50444.1 - 0.23 11.6 0.5 0.23 11.6 0.5 2.2 2 0 0 2 2 2 0 Zinc finger domain XPG_I_2 PF12813.7 ORX50445.1 - 2.9e-09 36.8 0.0 3.6e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 ORX50445.1 - 0.012 15.9 0.0 0.036 14.4 0.0 1.9 2 0 0 2 2 2 0 XPG I-region XPG_N PF00752.17 ORX50445.1 - 0.026 15.0 0.0 0.13 12.8 0.0 2.2 1 1 0 1 1 1 0 XPG N-terminal domain DUF1768 PF08719.11 ORX50446.1 - 2.6e-51 174.0 0.3 3e-51 173.9 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) CBM26 PF16738.5 ORX50446.1 - 1.2 9.5 5.3 6.8 7.0 1.8 2.5 3 0 0 3 3 3 0 Starch-binding module 26 SH3_9 PF14604.6 ORX50447.1 - 5.4e-31 106.2 1.0 1.7e-14 53.4 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX50447.1 - 8.2e-28 95.8 0.4 4.9e-14 51.7 0.1 2.5 2 0 0 2 2 2 2 SH3 domain FCH PF00611.23 ORX50447.1 - 7.6e-18 64.6 0.2 2.5e-17 62.9 0.2 2.0 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 ORX50447.1 - 2.6e-16 59.0 0.0 7.6e-09 35.1 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 ORX50447.1 - 5.7e-15 54.9 6.4 9.7e-15 54.2 6.4 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ORX50447.1 - 0.14 12.5 4.4 0.25 11.7 4.4 1.4 1 0 0 1 1 1 0 C1 domain JIP_LZII PF16471.5 ORX50447.1 - 1.5 9.1 8.9 2.2 8.5 1.6 3.3 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II ATP-synt_D PF01813.17 ORX50448.1 - 6.6e-76 254.5 6.5 8.9e-76 254.1 6.5 1.2 1 0 0 1 1 1 1 ATP synthase subunit D SIR2 PF02146.17 ORX50448.1 - 0.00023 21.2 0.0 0.00038 20.4 0.0 1.4 1 0 0 1 1 1 1 Sir2 family GnsAB_toxin PF08178.11 ORX50448.1 - 0.0049 16.8 1.3 0.012 15.5 0.1 2.3 2 0 0 2 2 2 1 GnsA/GnsB toxin of bacterial toxin-antitoxin system DUF948 PF06103.11 ORX50448.1 - 0.01 16.1 2.1 0.033 14.5 0.4 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 ORX50448.1 - 0.013 14.9 0.6 0.013 14.9 0.6 2.5 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding TACC_C PF05010.14 ORX50448.1 - 0.021 14.6 14.3 0.069 12.9 3.9 2.4 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Prefoldin PF02996.17 ORX50448.1 - 0.024 14.6 2.7 0.053 13.4 0.2 2.6 2 1 0 2 2 2 0 Prefoldin subunit Allexi_40kDa PF05549.11 ORX50448.1 - 0.047 13.2 1.4 4.3 6.8 0.2 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein AbiJ_NTD3 PF18860.1 ORX50448.1 - 0.058 12.9 0.6 0.17 11.4 0.1 1.8 2 0 0 2 2 2 0 AbiJ N-terminal domain 3 TSP_NTD PF17804.1 ORX50448.1 - 0.18 12.1 3.4 1.9 8.7 2.3 2.3 1 1 0 1 1 1 0 Tail specific protease N-terminal domain HlyE PF06109.13 ORX50448.1 - 0.24 10.7 3.7 1.5 8.1 0.4 2.1 2 0 0 2 2 2 0 Haemolysin E (HlyE) BLOC1_2 PF10046.9 ORX50448.1 - 0.43 10.9 4.7 0.35 11.2 1.1 2.3 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 ORX50448.1 - 3.6 7.6 8.1 0.29 11.2 1.5 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Nup88 PF10168.9 ORX50448.1 - 5.5 4.7 12.8 0.11 10.3 1.6 2.0 2 0 0 2 2 2 0 Nuclear pore component PTP_tm PF18861.1 ORX50449.1 - 0.038 14.0 0.0 0.067 13.2 0.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J SKG6 PF08693.10 ORX50449.1 - 0.061 12.7 0.1 0.21 11.0 0.1 1.9 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Axin_b-cat_bind PF08833.10 ORX50449.1 - 0.062 13.4 0.1 0.062 13.4 0.1 2.7 3 0 0 3 3 3 0 Axin beta-catenin binding domain Mucin15 PF15672.5 ORX50449.1 - 0.16 11.4 21.1 0.32 10.5 21.1 1.5 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 QWRF PF04484.12 ORX50449.1 - 0.82 9.3 8.2 1.2 8.8 8.2 1.2 1 0 0 1 1 1 0 QWRF family DUF1218 PF06749.12 ORX50450.1 - 0.029 14.9 0.8 0.029 14.9 0.8 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) Bac_export_2 PF01312.19 ORX50450.1 - 0.056 12.6 1.5 0.071 12.3 0.1 1.7 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family Kei1 PF08552.11 ORX50450.1 - 0.11 12.4 5.2 0.12 12.3 0.1 2.3 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Tetraspanin PF00335.20 ORX50450.1 - 0.7 9.6 19.6 9.7 5.8 19.6 2.1 1 1 0 1 1 1 0 Tetraspanin family 7tm_7 PF08395.12 ORX50450.1 - 1.6 7.9 12.3 4.6 6.4 11.9 1.9 1 1 1 2 2 2 0 7tm Chemosensory receptor DUF2981 PF11200.8 ORX50450.1 - 1.8 8.2 5.0 3 7.5 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) MerE PF05052.12 ORX50450.1 - 2.7 8.0 8.6 7.4 6.6 1.0 2.5 2 0 0 2 2 2 0 MerE protein Pkinase PF00069.25 ORX50452.1 - 4.3e-21 75.5 0.0 6.1e-21 75.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50452.1 - 4.9e-18 65.4 0.0 7.1e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Serinc PF03348.15 ORX50453.1 - 2.2e-161 537.6 16.1 2.5e-161 537.4 16.1 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) CitMHS PF03600.16 ORX50453.1 - 0.58 9.3 13.7 25 3.9 0.0 2.3 1 1 1 2 2 2 0 Citrate transporter RasGEF PF00617.19 ORX50455.1 - 8.8e-44 149.8 0.4 1.6e-43 149.0 0.4 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX50455.1 - 6e-19 68.2 2.0 1.2e-17 64.1 0.1 3.0 3 0 0 3 3 3 1 RasGEF N-terminal motif Arm_3 PF16186.5 ORX50455.1 - 0.12 11.9 0.3 0.36 10.4 0.3 1.7 1 0 0 1 1 1 0 Atypical Arm repeat Sec34 PF04136.15 ORX50456.1 - 0.0033 17.3 7.5 0.0078 16.1 7.4 1.6 1 1 0 1 1 1 1 Sec34-like family Zw10 PF06248.13 ORX50456.1 - 0.0065 15.1 4.8 0.008 14.8 4.8 1.0 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 DUF1569 PF07606.11 ORX50456.1 - 0.045 13.8 0.2 0.11 12.5 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1569) DUF4363 PF14276.6 ORX50456.1 - 0.045 13.9 4.4 0.12 12.5 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4363) Mod_r PF07200.13 ORX50456.1 - 0.047 13.8 6.3 0.072 13.2 6.3 1.4 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein COXG PF06240.13 ORX50456.1 - 0.073 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit G (CoxG) MCPsignal PF00015.21 ORX50456.1 - 0.16 11.8 3.2 0.23 11.3 0.4 2.0 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FUSC PF04632.12 ORX50456.1 - 0.19 10.2 3.0 0.23 9.9 3.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Nsp1_C PF05064.13 ORX50456.1 - 0.37 10.6 9.5 0.3 10.9 4.0 2.2 1 1 1 2 2 2 0 Nsp1-like C-terminal region Vps53_N PF04100.12 ORX50456.1 - 0.6 9.0 8.8 0.75 8.7 8.8 1.0 1 0 0 1 1 1 0 Vps53-like, N-terminal Rootletin PF15035.6 ORX50456.1 - 1.4 8.9 9.2 1.3 9.0 7.2 1.8 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion NPV_P10 PF05531.12 ORX50456.1 - 3.2 8.3 12.8 4 8.0 6.9 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein HSCB_C PF07743.13 ORX50456.1 - 6 7.4 9.2 2.2e+03 -0.8 9.2 2.9 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain COG4 PF08318.12 ORX50457.1 - 3.4e-42 144.7 3.9 3.4e-42 144.7 3.9 1.6 2 0 0 2 2 2 1 COG4 transport protein RINT1_TIP1 PF04437.13 ORX50457.1 - 7.9e-05 21.7 8.8 0.00011 21.3 8.3 1.4 1 1 0 1 1 1 1 RINT-1 / TIP-1 family Helitron_like_N PF14214.6 ORX50457.1 - 0.039 14.2 0.3 0.12 12.6 0.3 1.9 1 0 0 1 1 1 0 Helitron helicase-like domain at N-terminus cpYpsA PF12694.7 ORX50457.1 - 0.15 11.8 0.3 0.34 10.7 0.3 1.5 1 0 0 1 1 1 0 Circularly permutated YpsA SLOG family FliG_N PF14842.6 ORX50457.1 - 0.28 11.8 1.8 0.61 10.7 0.1 2.3 2 0 0 2 2 2 0 FliG N-terminal domain Methyltransf_21 PF05050.12 ORX50458.1 - 0.00018 21.5 0.0 0.00064 19.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase FkbM domain OmdA PF13376.6 ORX50458.1 - 0.019 14.9 0.1 0.049 13.7 0.1 1.7 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated Methyltransf_21 PF05050.12 ORX50459.1 - 9e-07 29.1 0.0 3.6e-06 27.1 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase FkbM domain Vps52 PF04129.12 ORX50460.1 - 1.4e-139 466.1 13.7 2e-139 465.6 13.7 1.2 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 ORX50460.1 - 9.8e-06 24.3 12.0 0.00053 18.5 0.4 2.7 1 1 1 2 2 2 2 Exocyst complex component Sec3 COG2 PF06148.11 ORX50460.1 - 5.4e-05 23.3 2.2 0.00011 22.4 0.9 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 HypF_C PF17788.1 ORX50460.1 - 0.046 14.4 2.6 0.4 11.4 0.0 3.4 4 1 1 5 5 5 0 HypF Kae1-like domain PLN_propep PF16485.5 ORX50460.1 - 0.21 11.3 1.5 0.85 9.4 0.0 2.7 3 0 0 3 3 3 0 Protealysin propeptide Baculo_PEP_C PF04513.12 ORX50460.1 - 0.33 11.0 1.7 10 6.2 0.1 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Cep57_MT_bd PF06657.13 ORX50460.1 - 1.1 9.8 3.4 0.85 10.1 0.2 2.6 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Cyclin PF08613.11 ORX50461.1 - 2.5e-37 128.7 0.5 4e-37 128.1 0.5 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX50461.1 - 0.019 14.7 0.1 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain zf-RING_2 PF13639.6 ORX50462.1 - 3.8e-08 33.5 5.3 3.8e-08 33.5 5.3 2.9 3 0 0 3 3 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX50462.1 - 3.9e-08 33.2 1.4 1.4e-07 31.4 1.4 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ORX50462.1 - 1.6e-07 31.3 3.2 5.2e-06 26.4 0.7 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ORX50462.1 - 6.2e-06 26.0 3.6 1.5e-05 24.8 3.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX50462.1 - 7.7e-06 25.7 3.1 7.7e-06 25.7 3.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX50462.1 - 0.00018 21.6 2.3 0.00018 21.6 2.3 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 ORX50462.1 - 0.00057 20.1 4.4 0.00057 20.1 4.4 2.5 3 0 0 3 3 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX50462.1 - 0.00065 19.6 4.1 0.00065 19.6 4.1 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 ORX50462.1 - 0.00086 19.0 1.7 0.0018 18.0 0.2 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX50462.1 - 0.0035 17.1 3.3 0.01 15.6 3.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX50462.1 - 0.0071 16.2 4.0 0.0071 16.2 4.0 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 Rad50_zn_hook PF04423.14 ORX50462.1 - 0.013 15.4 0.0 0.031 14.1 0.0 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-PARP PF00645.18 ORX50462.1 - 0.04 14.8 0.4 0.14 13.0 0.3 2.0 2 0 0 2 2 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WD40 PF00400.32 ORX50462.1 - 0.041 14.8 0.6 0.85 10.6 0.1 3.1 2 1 0 2 2 2 0 WD domain, G-beta repeat zf-Nse PF11789.8 ORX50462.1 - 0.05 13.4 0.8 0.11 12.4 0.8 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-BED PF02892.15 ORX50462.1 - 0.074 13.1 2.4 2 8.5 0.4 2.8 2 0 0 2 2 2 0 BED zinc finger GRIM-19 PF06212.12 ORX50462.1 - 0.098 12.6 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 GRIM-19 protein zf-RING_4 PF14570.6 ORX50462.1 - 0.12 12.2 2.4 0.26 11.1 2.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-Di19 PF05605.12 ORX50462.1 - 0.17 12.2 3.3 18 5.7 0.0 3.2 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-LITAF-like PF10601.9 ORX50462.1 - 5.2 7.4 11.4 2.2 8.6 3.3 2.9 2 1 0 2 2 2 0 LITAF-like zinc ribbon domain Zn_ribbon_SprT PF17283.2 ORX50462.1 - 6.5 6.8 7.9 1.3 9.0 3.5 2.2 2 0 0 2 2 1 0 SprT-like zinc ribbon domain FANCL_C PF11793.8 ORX50462.1 - 6.6 7.0 9.9 6.9 6.9 5.5 2.7 2 1 0 2 2 2 0 FANCL C-terminal domain Peptidase_C65 PF10275.9 ORX50463.1 - 5.4e-47 160.3 0.9 2.3e-46 158.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase C65 Otubain OTU PF02338.19 ORX50463.1 - 0.013 16.0 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 OTU-like cysteine protease Senescence PF06911.12 ORX50464.1 - 2e-13 51.1 0.1 6.2e-13 49.5 0.1 1.7 1 1 0 1 1 1 1 Senescence-associated protein Sec7 PF01369.20 ORX50465.1 - 1.2e-26 93.5 3.3 1.2e-26 93.5 3.3 2.5 2 1 0 2 2 2 1 Sec7 domain LAG1-DNAbind PF09271.11 ORX50466.1 - 9.6e-23 81.5 2.5 8.1e-13 49.3 0.4 2.5 1 1 1 2 2 2 2 LAG1, DNA binding BTD PF09270.10 ORX50466.1 - 8.8e-19 68.2 0.0 5.3e-18 65.7 0.0 2.3 2 1 0 2 2 2 1 Beta-trefoil DNA-binding domain NUFIP1 PF10453.9 ORX50467.1 - 1.1e-13 50.8 5.7 2.6e-13 49.6 5.7 1.7 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf-CCCH_4 PF18044.1 ORX50467.1 - 9.7e-07 28.4 2.9 1.9e-06 27.5 2.9 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 ORX50467.1 - 0.00012 21.9 3.1 0.00012 21.9 3.1 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX50467.1 - 0.00022 21.1 6.3 0.00048 20.1 6.3 1.6 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ORX50467.1 - 0.00044 20.9 0.6 0.00044 20.9 0.6 2.2 2 1 0 2 2 2 1 Torus domain zf-C2H2_jaz PF12171.8 ORX50467.1 - 0.013 15.8 2.3 0.038 14.3 2.3 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF1178 PF06676.11 ORX50467.1 - 0.44 10.9 3.1 1.1 9.6 3.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1178) zf-CCCH_2 PF14608.6 ORX50467.1 - 4.9 7.8 11.8 0.069 13.7 3.7 2.2 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger BCL_N PF04714.13 ORX50468.1 - 0.0017 18.4 2.7 0.0028 17.7 2.7 1.3 1 0 0 1 1 1 1 BCL7, N-terminal conserver region ANAPC9 PF12856.7 ORX50468.1 - 0.27 11.4 10.9 0.13 12.5 3.9 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 9 FAM176 PF14851.6 ORX50468.1 - 3.9 7.1 11.3 1.7 8.3 4.4 2.5 2 0 0 2 2 2 0 FAM176 family PBP1_TM PF14812.6 ORX50468.1 - 5.6 7.4 24.6 0.76 10.2 13.4 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ORX50468.1 - 7.8 5.7 24.9 0.48 9.7 13.3 2.1 2 0 0 2 2 2 0 NOA36 protein LRR_4 PF12799.7 ORX50469.1 - 1.9e-38 129.8 42.1 2.2e-07 31.1 0.0 8.9 6 3 3 9 9 9 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX50469.1 - 7.3e-31 105.7 46.8 3.8e-09 36.2 1.6 8.4 4 4 5 9 9 9 9 Leucine rich repeat LRR_9 PF14580.6 ORX50469.1 - 8.6e-17 61.2 14.1 3.8e-05 23.3 1.8 6.0 3 2 4 7 7 7 6 Leucine-rich repeat LRR_6 PF13516.6 ORX50469.1 - 6.7e-10 38.2 31.8 0.64 10.2 0.0 10.8 10 0 0 10 10 10 6 Leucine Rich repeat LRR_1 PF00560.33 ORX50469.1 - 2.2e-07 30.5 40.1 4.5 8.2 0.0 13.2 11 3 1 12 12 12 2 Leucine Rich Repeat Peptidase_M18 PF02127.15 ORX50471.1 - 5.6e-133 443.9 5.8 1.2e-94 317.6 6.2 4.0 1 1 1 2 2 2 2 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ORX50471.1 - 6e-07 28.8 0.4 5.4e-05 22.4 0.2 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase AHD PF17793.1 ORX50471.1 - 0.11 12.3 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 ANC1 homology domain (AHD) RFX_DNA_binding PF02257.15 ORX50472.1 - 1.3e-28 99.4 0.5 2.7e-28 98.4 0.5 1.5 1 0 0 1 1 1 1 RFX DNA-binding domain Pox_D5 PF03288.16 ORX50472.1 - 0.0031 18.0 0.0 0.0065 16.9 0.0 1.5 1 0 0 1 1 1 1 Poxvirus D5 protein-like DHHC PF01529.20 ORX50473.1 - 4.7e-37 127.1 10.3 4.7e-37 127.1 10.3 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase NnrU PF07298.11 ORX50473.1 - 1.6e-05 24.6 0.6 3.2e-05 23.6 0.6 1.4 1 0 0 1 1 1 1 NnrU protein Sensor PF13796.6 ORX50473.1 - 0.026 14.6 10.5 0.17 11.9 1.2 2.3 2 0 0 2 2 2 0 Putative sensor PA26 PF04636.13 ORX50474.1 - 4.1e-96 322.6 0.0 8e-96 321.6 0.0 1.3 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Pkinase PF00069.25 ORX50475.1 - 7e-72 242.0 0.0 1.1e-71 241.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50475.1 - 2.2e-48 164.8 0.0 3.3e-48 164.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX50475.1 - 1.6e-21 76.4 0.5 6.2e-21 74.5 0.1 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ORX50475.1 - 2.3e-06 26.6 0.0 2.3e-06 26.6 0.0 2.3 3 0 0 3 3 3 1 Fungal protein kinase Kinase-like PF14531.6 ORX50475.1 - 4.4e-06 26.2 0.0 7.9e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like DSHCT PF08148.12 ORX50475.1 - 0.0087 15.7 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 DSHCT (NUC185) domain Kdo PF06293.14 ORX50475.1 - 0.067 12.5 0.2 0.18 11.1 0.1 1.7 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX50475.1 - 0.12 12.2 0.2 1.1 9.1 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family PNRC PF15365.6 ORX50477.1 - 3.5e-05 23.5 9.3 3.5e-05 23.5 9.3 2.7 2 0 0 2 2 2 1 Proline-rich nuclear receptor coactivator motif WD40 PF00400.32 ORX50478.1 - 1.2e-05 25.9 0.0 0.04 14.8 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX50478.1 - 0.011 16.0 0.0 0.79 10.1 0.0 2.7 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CHCH PF06747.13 ORX50479.1 - 4.2e-07 29.9 4.8 8e-07 29.0 4.8 1.5 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 ORX50479.1 - 0.16 12.0 0.7 0.16 12.0 0.7 2.0 1 1 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Glyoxalase PF00903.25 ORX50480.1 - 2.2e-06 27.9 0.0 1.8e-05 24.9 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ORX50480.1 - 0.073 13.9 0.0 0.088 13.6 0.0 1.2 1 0 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_2 PF12681.7 ORX50480.1 - 0.13 12.2 0.0 0.5 10.3 0.0 1.8 2 0 0 2 2 2 0 Glyoxalase-like domain CAP_GLY PF01302.25 ORX50481.1 - 3.9e-21 74.8 0.1 6.3e-21 74.2 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain HAP1_N PF04849.13 ORX50481.1 - 0.003 16.8 6.0 0.003 16.8 6.0 2.9 2 1 1 3 3 3 1 HAP1 N-terminal conserved region CLIP1_ZNF PF16641.5 ORX50481.1 - 0.016 15.0 0.7 0.027 14.3 0.7 1.4 1 0 0 1 1 1 0 CLIP1 zinc knuckle DUF1281 PF06924.11 ORX50481.1 - 0.065 12.8 2.2 0.1 12.1 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Troponin PF00992.20 ORX50481.1 - 1.6 9.0 22.8 0.26 11.6 6.0 2.7 1 1 0 2 2 2 0 Troponin DUF948 PF06103.11 ORX50481.1 - 2.3 8.5 7.6 4.3 7.7 1.8 3.2 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF948) CorA PF01544.18 ORX50481.1 - 2.5 7.4 18.8 0.7 9.2 2.8 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein OrfB_IS605 PF01385.19 ORX50481.1 - 8.5 6.6 9.9 0.13 12.4 1.0 2.3 1 1 1 2 2 2 0 Probable transposase BLOC1_2 PF10046.9 ORX50481.1 - 8.6 6.7 14.5 11 6.4 0.1 3.6 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SPT_ssu-like PF11779.8 ORX50482.1 - 2e-10 40.1 0.2 2.6e-10 39.8 0.2 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like MFS_Mycoplasma PF07672.13 ORX50482.1 - 0.041 13.2 0.1 0.044 13.1 0.1 1.0 1 0 0 1 1 1 0 Mycoplasma MFS transporter ANAPC4_WD40 PF12894.7 ORX50483.1 - 5.3e-14 52.3 1.2 0.002 18.4 0.0 7.1 5 2 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX50483.1 - 1.6e-09 38.2 24.8 0.051 14.5 1.5 9.5 12 0 0 12 12 12 4 WD domain, G-beta repeat WD40_like PF17005.5 ORX50483.1 - 0.00049 19.5 0.4 0.61 9.4 0.6 3.8 3 1 0 3 3 3 2 WD40-like domain DUF2415 PF10313.9 ORX50483.1 - 0.0078 16.1 0.0 6.2 6.8 0.0 2.9 3 0 0 3 3 3 2 Uncharacterised protein domain (DUF2415) KH_6 PF15985.5 ORX50484.1 - 5.3e-17 61.9 0.1 9.5e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 KH domain Rrp40_N PF18311.1 ORX50484.1 - 5.5e-09 35.8 0.2 2.5e-08 33.7 0.0 2.1 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain SNF5 PF04855.12 ORX50485.1 - 4.9e-68 229.5 0.1 4.9e-68 229.5 0.1 1.7 2 0 0 2 2 2 1 SNF5 / SMARCB1 / INI1 Peptidase_C21 PF05381.12 ORX50485.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.7 1 0 0 1 1 1 0 Tymovirus endopeptidase XLF PF09302.11 ORX50485.1 - 0.44 10.7 3.8 0.46 10.6 0.1 2.5 2 1 1 3 3 3 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF543 PF04418.12 ORX50486.1 - 5.4e-24 84.0 0.1 6e-24 83.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) PGF-CTERM PF18204.1 ORX50486.1 - 1.4 9.0 3.8 5.9 7.0 0.1 2.2 2 0 0 2 2 2 0 PGF-CTERM motif Na_H_Exchanger PF00999.21 ORX50487.1 - 8.3e-55 186.1 25.3 1e-54 185.8 25.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Ribonuc_red_lgN PF00317.21 ORX50487.1 - 0.065 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain RELT PF12606.8 ORX50487.1 - 0.91 8.6 7.9 0.16 11.0 3.8 2.0 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 DUF4140 PF13600.6 ORX50488.1 - 0.099 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CATSPERD PF15020.6 ORX50489.1 - 0.21 9.8 0.0 0.25 9.6 0.0 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit delta cobW PF02492.19 ORX50492.1 - 5e-39 133.7 0.6 6.6e-39 133.3 0.6 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ORX50492.1 - 1.4e-05 24.9 0.1 2.5e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain SRP54 PF00448.22 ORX50492.1 - 0.0032 17.1 0.0 0.006 16.2 0.0 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain GTP_EFTU PF00009.27 ORX50492.1 - 0.0082 15.7 0.1 0.18 11.3 0.1 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MobB PF03205.14 ORX50492.1 - 0.0089 15.9 0.0 0.025 14.5 0.0 1.8 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ORX50492.1 - 0.012 15.9 0.0 0.037 14.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain tRNA_anti-codon PF01336.25 ORX50492.1 - 0.018 15.0 0.0 0.063 13.3 0.0 1.9 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain RsgA_GTPase PF03193.16 ORX50492.1 - 0.02 14.8 0.1 0.73 9.7 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_11 PF13086.6 ORX50492.1 - 0.023 14.5 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX50492.1 - 0.044 14.0 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Pox_A32 PF04665.12 ORX50492.1 - 0.053 13.0 0.0 0.094 12.2 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Viral_helicase1 PF01443.18 ORX50492.1 - 0.081 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_7 PF12775.7 ORX50492.1 - 0.086 12.3 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ORX50492.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain DUF1952 PF09189.10 ORX50492.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1952) DUF1177 PF06675.11 ORX50493.1 - 0.23 10.3 0.0 0.34 9.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1177) Haem_degrading PF03928.14 ORX50494.1 - 6.4e-32 110.1 0.0 8.7e-32 109.7 0.0 1.2 1 0 0 1 1 1 1 Haem-degrading SKIP_SNW PF02731.15 ORX50495.1 - 1.1e-71 239.7 0.5 1.1e-71 239.7 0.5 2.3 2 0 0 2 2 2 1 SKIP/SNW domain DAGK_acc PF00609.19 ORX50496.1 - 9.3e-11 42.3 0.0 1.7e-10 41.4 0.0 1.5 1 1 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ORX50496.1 - 1.7e-08 34.2 0.0 3.6e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Y_phosphatase2 PF03162.13 ORX50497.1 - 1.2e-55 187.6 0.0 1.4e-55 187.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX50497.1 - 9.8e-06 25.7 0.0 2.9e-05 24.2 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX50497.1 - 0.0094 15.8 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX50497.1 - 0.045 13.3 0.0 0.059 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Kelch_5 PF13854.6 ORX50498.1 - 2.3e-25 88.1 0.7 3.1e-06 27.0 0.0 6.7 6 0 0 6 6 6 5 Kelch motif Kelch_4 PF13418.6 ORX50498.1 - 2.7e-19 68.9 5.8 1.2e-05 25.2 0.0 5.8 4 2 1 5 5 5 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX50498.1 - 6.1e-14 51.9 10.0 0.00065 19.9 0.0 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX50498.1 - 1.8e-12 47.1 16.7 0.00022 21.4 0.1 5.7 4 1 2 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ORX50498.1 - 0.00014 21.4 0.1 2.8 7.6 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ORX50498.1 - 0.00025 20.9 8.8 2 8.6 0.0 5.8 6 1 0 6 6 6 1 Kelch motif WD40 PF00400.32 ORX50500.1 - 9.1e-27 92.8 4.1 1.3e-06 29.0 0.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX50500.1 - 1.6e-08 34.7 0.9 0.016 15.5 0.2 4.2 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX50500.1 - 0.00027 20.4 0.1 0.0031 16.9 0.0 2.4 2 1 0 3 3 3 1 WD40-like domain Ge1_WD40 PF16529.5 ORX50500.1 - 0.00079 18.5 1.5 0.33 9.9 0.5 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX50500.1 - 0.0095 14.6 0.7 0.027 13.1 0.2 1.9 2 0 0 2 2 2 1 Nucleoporin Nup120/160 KH_1 PF00013.29 ORX50501.1 - 4.6e-63 208.9 16.7 1.6e-12 47.0 2.5 8.6 9 0 0 9 9 9 7 KH domain KH_2 PF07650.17 ORX50501.1 - 4.6e-06 26.4 8.7 0.017 14.9 1.4 3.9 3 0 0 3 3 3 2 KH domain DIE2_ALG10 PF04922.12 ORX50502.1 - 8.1e-118 394.1 30.8 9.9e-118 393.8 30.8 1.1 1 0 0 1 1 1 1 DIE2/ALG10 family adh_short PF00106.25 ORX50504.1 - 7.2e-27 94.1 0.0 7.6e-26 90.8 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX50504.1 - 3.1e-14 53.1 0.0 2.1e-13 50.4 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX50504.1 - 2.8e-06 27.3 0.0 3.9e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 KR domain THF_DHG_CYH_C PF02882.19 ORX50504.1 - 0.11 11.8 0.1 0.19 11.1 0.1 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ORX50504.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family TPR_1 PF00515.28 ORX50505.1 - 9e-43 142.4 38.9 4.3e-07 29.5 0.0 15.5 15 0 0 15 15 15 11 Tetratricopeptide repeat TPR_2 PF07719.17 ORX50505.1 - 1.2e-40 134.3 35.3 0.0002 21.2 0.0 16.0 16 0 0 16 16 16 10 Tetratricopeptide repeat TPR_12 PF13424.6 ORX50505.1 - 7.3e-38 128.7 39.5 8.9e-10 38.7 4.3 11.5 8 3 2 10 10 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 ORX50505.1 - 8.1e-36 122.4 35.0 1.5e-11 44.6 0.5 10.8 6 5 3 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX50505.1 - 1.6e-30 105.4 18.7 3.7e-07 30.7 0.0 8.5 5 1 4 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ORX50505.1 - 3.5e-30 101.7 36.5 0.00052 20.0 0.0 15.3 16 0 0 16 16 15 9 Tetratricopeptide repeat TPR_14 PF13428.6 ORX50505.1 - 2.4e-28 96.4 14.3 0.0065 17.2 0.0 14.7 6 4 10 16 16 15 6 Tetratricopeptide repeat TPR_7 PF13176.6 ORX50505.1 - 8.4e-24 81.8 29.3 1.8e-06 27.6 0.0 14.0 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_6 PF13174.6 ORX50505.1 - 1e-19 69.7 35.0 0.0011 19.4 0.1 15.1 16 0 0 16 16 16 5 Tetratricopeptide repeat TPR_17 PF13431.6 ORX50505.1 - 1.3e-18 65.9 36.0 3.4e-06 27.1 0.6 13.3 15 0 0 15 15 15 4 Tetratricopeptide repeat TPR_10 PF13374.6 ORX50505.1 - 7.1e-14 51.2 28.4 0.00021 21.0 0.1 11.8 13 0 0 13 13 13 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX50505.1 - 1.8e-13 50.5 25.0 5e-05 23.4 0.2 6.7 5 2 3 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ORX50505.1 - 4.9e-13 48.5 32.0 0.0047 16.6 0.0 11.5 7 4 5 12 12 12 4 TPR repeat TPR_9 PF13371.6 ORX50505.1 - 1.3e-10 41.2 5.9 0.17 12.1 0.0 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 ORX50505.1 - 1.2e-06 27.9 17.9 7.8e-05 22.0 0.5 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_4 PF07721.14 ORX50505.1 - 1.8e-06 28.0 10.5 10 7.0 0.0 9.0 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF2225 PF09986.9 ORX50505.1 - 7.5e-05 22.5 1.2 7.5e-05 22.5 1.2 4.0 3 2 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ORX50505.1 - 0.00016 21.6 22.4 0.075 13.1 0.0 7.3 9 0 0 9 9 7 3 Tetratricopeptide repeat ChAPs PF09295.10 ORX50505.1 - 0.00026 20.1 8.2 0.37 9.7 0.4 3.4 3 1 0 3 3 3 3 ChAPs (Chs5p-Arf1p-binding proteins) PPR PF01535.20 ORX50505.1 - 0.0023 18.1 0.0 5.1 7.6 0.0 5.6 6 0 0 6 6 6 1 PPR repeat SHNi-TPR PF10516.9 ORX50505.1 - 0.39 10.2 0.0 0.39 10.2 0.0 5.2 7 0 0 7 7 7 0 SHNi-TPR RPN2_C PF18004.1 ORX50506.1 - 1.5e-53 181.0 8.9 2.4e-53 180.3 8.9 1.4 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 ORX50506.1 - 9.5e-40 133.1 16.2 1.8e-07 31.3 0.1 8.1 7 0 0 7 7 7 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ORX50506.1 - 3.4e-20 72.2 0.3 3e-14 53.2 0.0 5.4 3 2 4 7 7 7 4 HEAT repeats HEAT PF02985.22 ORX50506.1 - 5.5e-06 26.2 1.5 0.98 9.9 0.1 5.8 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 ORX50506.1 - 0.00017 22.0 0.4 0.16 12.5 0.1 5.1 5 1 1 6 6 6 1 HEAT-like repeat Katanin_con80 PF13925.6 ORX50506.1 - 0.0085 16.1 1.4 5.7 6.9 0.2 3.5 3 1 1 4 4 4 1 con80 domain of Katanin Arm PF00514.23 ORX50506.1 - 0.015 15.3 0.2 5.4 7.2 0.0 3.8 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PHD20L1_u1 PF16660.5 ORX50506.1 - 0.04 14.7 1.6 0.094 13.5 1.6 1.6 1 0 0 1 1 1 0 PHD finger protein 20-like protein 1 FliG_M PF14841.6 ORX50506.1 - 0.079 13.2 1.1 2.2 8.6 0.1 3.3 3 0 0 3 3 3 0 FliG middle domain BtrH_N PF14399.6 ORX50506.1 - 0.13 12.5 0.0 11 6.2 0.0 3.2 3 0 0 3 3 3 0 Butirosin biosynthesis protein H, N-terminal Vfa1 PF08432.10 ORX50506.1 - 0.17 12.2 10.3 2.8 8.3 7.4 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 HEAT_PBS PF03130.16 ORX50506.1 - 0.47 11.3 5.3 6.2 7.8 0.1 4.5 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat DUF719 PF05334.13 ORX50506.1 - 1.1 9.4 5.1 8.2 6.6 4.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) HSF_DNA-bind PF00447.17 ORX50507.1 - 2.8e-31 108.0 1.3 7.2e-31 106.7 1.3 1.8 1 0 0 1 1 1 1 HSF-type DNA-binding PI_PP_I PF18363.1 ORX50507.1 - 0.021 15.0 5.2 0.045 13.9 0.5 3.1 3 1 0 3 3 3 0 Phosphoinositide phosphatase insertion domain DUF29 PF01724.16 ORX50507.1 - 0.4 10.9 4.0 0.68 10.2 2.8 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF29 Rap_GAP PF02145.15 ORX50508.1 - 4e-17 62.4 0.0 1.1e-16 60.9 0.0 1.7 1 0 0 1 1 1 1 Rap/ran-GAP Nucleos_tra2_C PF07662.13 ORX50509.1 - 3.4e-69 232.8 7.6 3.4e-69 232.8 7.6 2.0 2 0 0 2 2 2 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 ORX50509.1 - 7.4e-20 71.3 2.3 7.4e-20 71.3 2.3 3.0 3 1 1 4 4 4 1 Na+ dependent nucleoside transporter N-terminus DUF5357 PF17310.2 ORX50509.1 - 3.8 6.0 12.0 0.34 9.4 1.5 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5357) NIF PF03031.18 ORX50511.1 - 4e-23 81.9 1.0 4.8e-23 81.6 0.4 1.4 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase DNA_topoisoIV PF00521.20 ORX50511.1 - 0.15 10.9 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Glyco_tranf_2_3 PF13641.6 ORX50512.1 - 9e-24 84.6 0.0 1.1e-23 84.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ORX50512.1 - 4.4e-08 32.8 0.6 9.3e-07 28.5 0.6 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX50512.1 - 3.9e-07 30.0 0.0 6.1e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 SLIDE PF09111.10 ORX50512.1 - 0.038 14.0 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 SLIDE Pkinase PF00069.25 ORX50513.1 - 1.3e-66 224.7 0.0 1.6e-66 224.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50513.1 - 1.5e-24 86.7 0.0 7e-24 84.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX50513.1 - 4.3e-08 32.8 0.1 2e-05 24.0 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 ORX50513.1 - 0.032 14.2 0.0 0.15 12.0 0.0 2.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX50513.1 - 0.1 11.3 0.0 4 6.1 0.0 2.1 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 ORX50513.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Fungal_trans PF04082.18 ORX50514.1 - 1.5e-05 24.1 4.1 4e-05 22.8 4.1 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF4733 PF15878.5 ORX50514.1 - 0.5 10.9 3.1 22 5.6 0.2 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4733) Acetyltransf_10 PF13673.7 ORX50515.1 - 2.3e-12 47.0 0.0 7.3e-12 45.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX50515.1 - 3.8e-12 46.5 0.0 4.6e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX50515.1 - 6.8e-10 39.2 0.0 1.1e-09 38.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX50515.1 - 0.00011 22.3 0.0 0.00033 20.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ORX50515.1 - 0.0011 18.9 0.1 0.0023 17.9 0.1 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_15 PF17013.5 ORX50515.1 - 0.0046 16.4 0.0 0.048 13.1 0.0 2.0 2 0 0 2 2 2 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 ORX50515.1 - 0.023 15.4 0.0 0.032 14.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX50515.1 - 0.067 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase NitrOD2 PF18550.1 ORX50515.1 - 0.19 11.9 0.0 0.28 11.3 0.0 1.2 1 0 0 1 1 1 0 Nitrososphaera output domain 2 DUF4203 PF13886.6 ORX50516.1 - 9.1e-36 123.4 37.9 1.3e-35 122.9 37.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF1418 PF07214.12 ORX50516.1 - 0.76 9.7 0.0 0.76 9.7 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1418) OrfB_Zn_ribbon PF07282.11 ORX50517.1 - 0.00015 21.6 1.3 0.00027 20.8 1.0 1.5 1 1 0 1 1 1 1 Putative transposase DNA-binding domain TMEM154 PF15102.6 ORX50517.1 - 0.16 11.9 1.3 0.2 11.6 1.3 1.2 1 0 0 1 1 1 0 TMEM154 protein family OrfB_Zn_ribbon PF07282.11 ORX50518.1 - 6.7e-09 35.6 0.6 0.0022 17.9 0.2 2.5 2 0 0 2 2 2 2 Putative transposase DNA-binding domain FHIPEP PF00771.20 ORX50519.1 - 0.01 14.3 0.0 0.011 14.2 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family Sec34 PF04136.15 ORX50519.1 - 0.02 14.8 2.1 0.024 14.5 2.1 1.1 1 0 0 1 1 1 0 Sec34-like family ANAPC2 PF08672.11 ORX50519.1 - 0.035 14.6 1.0 3.6 8.2 0.2 2.1 1 1 1 2 2 2 0 Anaphase promoting complex (APC) subunit 2 Ribosomal_L29 PF00831.23 ORX50519.1 - 0.058 13.4 2.2 0.56 10.2 0.3 2.1 2 0 0 2 2 2 0 Ribosomal L29 protein Fzo_mitofusin PF04799.13 ORX50519.1 - 0.065 12.8 0.4 0.073 12.6 0.4 1.1 1 0 0 1 1 1 0 fzo-like conserved region DUF4248 PF14053.6 ORX50519.1 - 0.075 13.1 0.2 0.19 11.8 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) SKA2 PF16740.5 ORX50519.1 - 0.21 11.4 8.3 0.26 11.1 1.0 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Actin PF00022.19 ORX50520.1 - 8e-152 505.6 0.0 2.7e-151 503.8 0.0 1.7 1 1 0 1 1 1 1 Actin VGLL4 PF15245.6 ORX50521.1 - 0.25 11.4 3.5 0.28 11.2 3.5 1.1 1 0 0 1 1 1 0 Transcription cofactor vestigial-like protein 4 SPRY PF00622.28 ORX50522.1 - 7e-08 32.6 0.1 8e-06 26.0 0.0 3.3 3 0 0 3 3 3 1 SPRY domain tRNA-synt_2 PF00152.20 ORX50523.1 - 7.2e-76 255.3 0.0 9.2e-76 254.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX50523.1 - 1.3e-12 47.5 0.0 2.5e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX50523.1 - 3.5e-09 36.5 0.0 0.00033 20.2 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) Usp PF00582.26 ORX50524.1 - 4.2e-19 69.4 0.2 5.8e-19 69.0 0.2 1.2 1 0 0 1 1 1 1 Universal stress protein family 2OG-FeII_Oxy_3 PF13640.6 ORX50525.1 - 1.3e-20 74.1 0.1 2.2e-20 73.4 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ORX50525.1 - 4.9e-11 43.1 0.0 9.1e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3048_C PF17479.2 ORX50525.1 - 0.12 12.8 0.0 0.3 11.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3048) C-terminal domain NIF PF03031.18 ORX50526.1 - 1.3e-17 64.1 0.0 1.6e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Na_sulph_symp PF00939.19 ORX50527.1 - 3.4e-34 118.7 39.1 4.4e-34 118.3 39.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region SPX PF03105.19 ORX50527.1 - 4.3e-30 105.9 18.7 9e-14 52.2 2.0 3.2 1 1 2 3 3 3 3 SPX domain CitMHS PF03600.16 ORX50527.1 - 7.6e-26 91.0 68.7 8.9e-23 80.9 40.1 2.4 1 1 1 2 2 2 2 Citrate transporter Stathmin PF00836.19 ORX50527.1 - 1 9.3 6.5 3 7.8 0.3 2.4 2 0 0 2 2 2 0 Stathmin family TPR_16 PF13432.6 ORX50528.1 - 0.0088 16.7 5.4 0.062 14.0 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX50528.1 - 8.9 6.7 19.6 0.74 10.1 0.4 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat Lyase_1 PF00206.20 ORX50529.1 - 4e-121 404.2 0.0 5.9e-121 403.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ORX50529.1 - 8.9e-24 83.7 0.1 2.2e-23 82.4 0.1 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus DUF4288 PF14119.6 ORX50529.1 - 0.047 14.1 0.0 0.098 13.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) NusB PF01029.18 ORX50529.1 - 0.075 13.3 0.0 2.9 8.1 0.0 2.4 2 0 0 2 2 2 0 NusB family RPN7 PF10602.9 ORX50530.1 - 4.8e-59 199.0 0.4 7.8e-59 198.3 0.4 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ORX50530.1 - 6.4e-15 55.6 0.1 8.9e-14 51.9 0.0 2.6 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 ORX50530.1 - 0.045 13.7 0.1 0.088 12.8 0.1 1.6 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family TPR_6 PF13174.6 ORX50530.1 - 0.48 11.2 1.7 1.6 9.6 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX50530.1 - 1.2 9.5 3.9 1.9 8.9 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat RPN6_N PF18055.1 ORX50531.1 - 3.7e-40 136.9 2.8 3.7e-40 136.9 2.8 2.3 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 ORX50531.1 - 1.2e-18 67.5 0.1 1.2e-18 67.5 0.1 3.2 4 0 0 4 4 4 1 PCI domain RPN6_C_helix PF18503.1 ORX50531.1 - 4.3e-11 42.3 0.6 1.2e-10 40.9 0.6 1.9 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_7 PF13176.6 ORX50531.1 - 0.013 15.5 4.9 65 3.9 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX50531.1 - 0.028 13.8 4.2 0.026 13.9 2.3 1.9 1 1 1 2 2 2 0 MalT-like TPR region ATPgrasp_N PF18130.1 ORX50531.1 - 0.04 14.5 0.0 0.17 12.4 0.0 2.1 1 0 0 1 1 1 0 ATP-grasp N-terminal domain TPR_16 PF13432.6 ORX50531.1 - 0.057 14.1 0.7 8.3 7.1 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX50531.1 - 0.094 13.6 6.7 1.9 9.5 0.2 4.8 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX50531.1 - 0.15 12.6 7.0 5.8 7.5 0.5 4.5 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX50531.1 - 3.9 8.3 6.8 9.1 7.2 0.1 4.6 7 0 0 7 7 7 0 Tetratricopeptide repeat DnaJ_C PF01556.18 ORX50532.1 - 1.8e-40 138.4 0.2 2.3e-40 138.1 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX50532.1 - 4.6e-26 90.7 0.2 8.1e-26 89.9 0.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX50532.1 - 1e-15 57.8 19.4 1.6e-15 57.2 19.4 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ORX50532.1 - 0.29 11.1 15.7 0.13 12.2 1.7 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ORX50532.1 - 4.5 7.3 10.1 10 6.2 0.9 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA KH_1 PF00013.29 ORX50533.1 - 2.4e-29 101.0 0.0 3.7e-08 33.1 0.0 6.3 6 0 0 6 6 6 5 KH domain DUF3919 PF13057.6 ORX50533.1 - 0.049 13.2 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3919) SUIM_assoc PF16619.5 ORX50533.1 - 2.5 8.2 9.7 0.5 10.5 5.5 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Macoilin PF09726.9 ORX50533.1 - 9 4.7 19.0 0.11 11.1 3.4 2.2 2 0 0 2 2 2 0 Macoilin family Pkinase PF00069.25 ORX50534.1 - 6e-71 238.9 0.1 9.1e-71 238.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50534.1 - 1.1e-50 172.4 0.1 1.1e-50 172.4 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 ORX50534.1 - 1.6e-20 73.2 0.0 4.5e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 ORX50534.1 - 2.7e-14 53.5 0.6 5.4e-14 52.6 0.6 1.5 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ORX50534.1 - 2.7e-07 30.2 0.0 4.8e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX50534.1 - 6.1e-07 28.6 3.2 1.3e-06 27.5 3.2 1.6 1 1 0 1 1 1 1 Fungal protein kinase PH_11 PF15413.6 ORX50534.1 - 5e-05 23.7 0.9 0.0049 17.3 0.9 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 ORX50534.1 - 0.0018 17.9 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Haspin_kinase PF12330.8 ORX50534.1 - 0.011 14.8 0.1 0.024 13.6 0.1 1.5 1 0 0 1 1 1 0 Haspin like kinase domain PH_9 PF15410.6 ORX50534.1 - 0.021 15.2 0.4 3 8.2 0.4 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain Seadorna_VP7 PF07387.11 ORX50534.1 - 0.025 13.7 0.1 0.045 12.8 0.1 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 PUA_2 PF14306.6 ORX50534.1 - 0.025 14.2 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 PUA-like domain APH PF01636.23 ORX50534.1 - 1.6 8.6 5.0 7.2 6.4 0.5 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kelch_6 PF13964.6 ORX50536.1 - 3.5e-06 27.1 0.0 5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 ORX50536.1 - 0.0018 17.8 0.0 0.0024 17.4 0.0 1.2 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 ORX50536.1 - 0.0019 18.5 0.0 0.0025 18.1 0.0 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX50536.1 - 0.002 18.1 0.0 0.0028 17.6 0.0 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ORX50536.1 - 0.0026 17.7 0.1 0.0055 16.7 0.1 1.6 1 1 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX50536.1 - 0.021 14.8 0.1 0.06 13.3 0.1 1.8 1 1 0 1 1 1 0 Kelch motif LigB PF02900.18 ORX50536.1 - 0.091 11.8 0.1 0.091 11.8 0.1 1.1 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Kelch_2 PF07646.15 ORX50537.1 - 4.4e-21 74.0 4.2 1.3e-06 28.2 0.1 4.8 4 1 0 4 4 4 4 Kelch motif Kelch_4 PF13418.6 ORX50537.1 - 3.7e-19 68.5 7.5 3.3e-08 33.4 0.6 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX50537.1 - 2.4e-17 62.2 5.0 9.8e-05 21.9 0.0 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ORX50537.1 - 8e-17 60.8 1.2 2.1e-05 24.4 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 ORX50537.1 - 1.7e-15 56.6 6.0 0.00048 20.3 0.1 4.5 4 1 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ORX50537.1 - 1.3e-13 50.9 10.3 2.6e-06 27.6 0.1 6.1 5 1 0 5 5 5 3 Galactose oxidase, central domain BTB PF00651.31 ORX50537.1 - 8.7e-12 45.3 2.0 9e-11 42.0 0.0 3.1 4 1 0 4 4 4 1 BTB/POZ domain adh_short PF00106.25 ORX50539.1 - 6.8e-34 117.0 0.0 2.3e-26 92.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX50539.1 - 1.8e-20 73.5 0.1 4.6e-16 59.1 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX50539.1 - 1.6e-05 24.9 0.1 2.9e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 KR domain Spt4 PF06093.13 ORX50544.1 - 2.4e-31 107.7 0.2 2.8e-31 107.4 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger zf-C2H2 PF00096.26 ORX50545.1 - 7.5e-11 41.9 20.0 3.2e-06 27.3 2.6 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX50545.1 - 1.6e-07 31.5 16.5 0.00026 21.6 1.5 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX50545.1 - 3.6e-06 27.1 15.1 1e-05 25.7 3.5 3.1 3 0 0 3 3 3 2 Zinc-finger double domain FOXP-CC PF16159.5 ORX50545.1 - 0.00021 21.8 4.5 0.0036 17.9 0.1 2.1 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX50545.1 - 0.0053 16.7 1.7 0.0053 16.7 1.7 2.9 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX50545.1 - 0.0089 16.3 3.5 24 5.3 0.5 2.0 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 ORX50545.1 - 0.02 15.3 3.9 1.2 9.7 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 ORX50545.1 - 0.044 13.5 0.7 0.044 13.5 0.7 4.0 4 0 0 4 4 4 0 C2H2-type zinc-finger domain TRAF6_Z2 PF18048.1 ORX50545.1 - 0.074 13.2 11.5 0.53 10.4 2.4 3.1 2 2 1 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 RPAP2_Rtr1 PF04181.13 ORX50545.1 - 0.076 13.3 2.1 0.48 10.8 0.2 2.0 1 1 1 2 2 2 0 Rtr1/RPAP2 family zf-C2H2_2 PF12756.7 ORX50545.1 - 0.099 13.0 9.7 0.53 10.6 0.4 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX50545.1 - 0.18 12.1 0.9 0.18 12.1 0.9 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 ORX50545.1 - 0.25 11.4 5.1 1.4 9.1 5.1 1.8 1 1 0 1 1 1 0 Aberrant zinc-finger zf-C2HE PF16278.5 ORX50545.1 - 0.84 10.1 11.7 1.6 9.2 4.2 2.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 ORX50546.1 - 2.6e-11 43.3 11.2 1.7e-05 25.0 2.9 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX50546.1 - 5.4e-07 29.9 11.7 0.0038 17.9 3.2 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX50546.1 - 1.5e-05 25.2 2.2 1.5e-05 25.2 2.2 2.9 3 0 0 3 3 3 1 Zinc-finger double domain FOXP-CC PF16159.5 ORX50546.1 - 0.0084 16.7 3.0 0.095 13.3 0.1 2.1 1 1 1 2 2 2 1 FOXP coiled-coil domain Ogr_Delta PF04606.12 ORX50546.1 - 0.033 14.2 0.8 0.37 10.8 0.2 2.2 1 1 1 2 2 2 0 Ogr/Delta-like zinc finger zf-C2H2_aberr PF17017.5 ORX50546.1 - 0.33 11.1 4.1 2.6 8.2 0.5 2.0 1 1 1 2 2 2 0 Aberrant zinc-finger GSH_synth_ATP PF03917.17 ORX50547.1 - 2e-138 461.2 0.0 2.4e-138 461.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ORX50547.1 - 3.9e-36 123.6 0.0 7.3e-36 122.7 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic glutathione synthase PhaP_Bmeg PF09602.10 ORX50547.1 - 0.0044 17.0 0.2 0.0079 16.1 0.2 1.3 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) LOH1CR12 PF10158.9 ORX50547.1 - 0.21 11.6 0.9 0.54 10.3 0.9 1.6 1 1 0 1 1 1 0 Tumour suppressor protein EF-hand_1 PF00036.32 ORX50548.1 - 7.5e-31 103.4 6.6 9.1e-11 40.5 1.0 3.2 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ORX50548.1 - 2.8e-26 91.1 5.9 6.6e-15 54.7 0.4 3.0 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 ORX50548.1 - 2.4e-25 88.8 1.8 2.4e-18 66.3 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX50548.1 - 1.2e-21 74.7 2.6 1.5e-09 37.0 0.0 3.5 3 1 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ORX50548.1 - 3.8e-19 67.2 5.4 6.5e-07 28.6 0.1 3.4 3 1 0 3 3 3 3 EF hand EF-hand_9 PF14658.6 ORX50548.1 - 2.4e-10 40.6 0.2 0.00026 21.2 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX50548.1 - 3.3e-06 27.0 0.8 0.00012 22.0 0.1 2.0 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX50548.1 - 3.9e-06 27.2 0.0 0.00015 22.1 0.0 2.0 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ORX50548.1 - 9e-05 22.6 0.6 0.019 15.2 0.1 2.5 1 1 2 3 3 3 2 Dockerin type I domain EFhand_Ca_insen PF08726.10 ORX50548.1 - 0.00011 22.2 0.3 0.00026 21.0 0.3 1.7 1 1 0 1 1 1 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 ORX50548.1 - 0.00027 21.8 0.0 0.00063 20.6 0.0 1.6 1 1 1 2 2 2 1 EF-hand domain DUF2267 PF10025.9 ORX50548.1 - 0.0028 17.9 0.7 0.081 13.2 0.7 2.2 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2267) DUF5580 PF17743.1 ORX50548.1 - 0.0031 16.1 0.0 0.0033 16.0 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) TerB PF05099.13 ORX50548.1 - 0.0095 15.9 0.9 1.6 8.7 0.1 2.0 1 1 1 2 2 2 2 Tellurite resistance protein TerB DUF4497 PF14924.6 ORX50548.1 - 0.026 15.0 0.0 0.032 14.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) DUF3349 PF11829.8 ORX50548.1 - 0.03 15.1 0.6 9.9 7.0 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.16 ORX50548.1 - 0.043 14.2 0.6 0.23 11.8 0.1 2.1 2 1 0 2 2 2 0 RNA polymerase Rpb4 SurA_N_2 PF13623.6 ORX50548.1 - 0.052 13.4 0.6 0.38 10.6 0.4 2.0 1 1 1 2 2 2 0 SurA N-terminal domain UPF0154 PF03672.13 ORX50548.1 - 0.081 13.0 0.3 1.1 9.4 0.0 2.7 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0154) CMD PF02627.20 ORX50548.1 - 0.096 12.7 0.1 1.3 9.1 0.0 2.1 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family Spore_III_AB PF09548.10 ORX50548.1 - 0.1 12.7 0.1 0.14 12.3 0.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) MotA_activ PF09114.10 ORX50548.1 - 0.11 12.7 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 Transcription factor MotA, activation domain Caleosin PF05042.13 ORX50548.1 - 0.11 12.5 0.5 9.7 6.1 0.0 2.8 1 1 2 3 3 3 0 Caleosin related protein Flavodoxin_2 PF02525.17 ORX50549.1 - 1.2e-35 123.0 0.0 1.5e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 ORX50549.1 - 7.8e-06 25.7 0.0 1.1e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Pkinase PF00069.25 ORX50550.1 - 9.2e-60 202.2 0.0 1.5e-59 201.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50550.1 - 9.8e-29 100.4 0.0 1.6e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX50550.1 - 4.3e-09 36.9 1.0 4.3e-09 36.9 1.0 2.7 3 0 0 3 3 3 1 Protein kinase C terminal domain PX PF00787.24 ORX50550.1 - 0.00026 21.0 3.8 0.002 18.1 3.8 2.5 1 1 0 1 1 1 1 PX domain Pkinase_fungal PF17667.1 ORX50550.1 - 0.0017 17.2 0.0 0.0072 15.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase FTA2 PF13095.6 ORX50550.1 - 0.002 17.8 0.3 0.48 10.0 0.0 2.6 2 1 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ORX50550.1 - 0.0023 17.3 0.1 0.0072 15.7 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX50550.1 - 0.071 12.5 0.1 0.071 12.5 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family TRAPP PF04051.16 ORX50551.1 - 5.7e-46 155.9 0.0 6.8e-46 155.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Phage_P2_GpE PF06528.12 ORX50551.1 - 0.13 11.8 0.6 0.26 10.9 0.6 1.4 1 0 0 1 1 1 0 Phage P2 GpE SUI1 PF01253.22 ORX50552.1 - 3.6e-19 69.1 0.0 1e-18 67.6 0.0 1.8 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 ORX50552.1 - 5.5e-13 49.4 7.6 9.4e-13 48.7 3.6 3.0 2 1 0 2 2 2 1 Pre-PUA-like domain PUA PF01472.20 ORX50552.1 - 3.6e-05 23.6 0.0 8e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 PUA domain SWIB PF02201.18 ORX50552.1 - 0.0071 16.2 0.5 0.017 15.0 0.5 1.6 1 0 0 1 1 1 1 SWIB/MDM2 domain Kin17_mid PF10357.9 ORX50552.1 - 0.016 15.1 2.2 0.021 14.7 0.1 2.3 3 0 0 3 3 3 0 Domain of Kin17 curved DNA-binding protein Peptidase_S9 PF00326.21 ORX50553.1 - 5.5e-07 29.3 0.0 8.4e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family COesterase PF00135.28 ORX50553.1 - 4.1e-06 25.9 0.1 7.6e-05 21.8 0.0 2.0 1 1 1 2 2 2 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX50553.1 - 5.7e-06 26.3 0.1 0.092 12.6 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX50553.1 - 0.0015 17.9 0.0 2.4 7.4 0.1 3.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX50553.1 - 0.0024 18.5 0.0 1.4 9.5 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family FSH1 PF03959.13 ORX50553.1 - 0.024 14.3 0.0 0.045 13.4 0.0 1.4 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Tannase PF07519.11 ORX50553.1 - 0.11 11.4 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Tannase and feruloyl esterase PAF-AH_p_II PF03403.13 ORX50553.1 - 0.11 11.0 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II MttA_Hcf106 PF02416.16 ORX50553.1 - 0.15 11.4 0.0 0.34 10.3 0.0 1.5 1 0 0 1 1 1 0 mttA/Hcf106 family Abhydrolase_1 PF00561.20 ORX50553.1 - 0.15 11.6 0.0 0.78 9.3 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ORX50553.1 - 0.17 11.7 0.0 1.5 8.5 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Acetyltransf_1 PF00583.25 ORX50554.1 - 3.6e-07 30.4 0.0 1.9e-06 28.1 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 ORX50554.1 - 0.00092 19.9 0.3 0.11 13.2 0.0 2.4 1 1 1 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX50554.1 - 0.0019 18.6 0.1 0.77 10.2 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX50554.1 - 0.0045 16.9 0.0 0.96 9.4 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Autophagy_act_C PF03987.15 ORX50555.1 - 1.8e-18 66.8 0.3 1.8e-18 66.8 0.3 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain Sec7 PF01369.20 ORX50556.1 - 5e-29 101.3 0.1 1.1e-28 100.1 0.1 1.6 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 ORX50556.1 - 1.8e-22 79.9 0.0 7.9e-22 77.9 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ORX50556.1 - 0.0026 18.2 0.0 0.013 16.0 0.0 2.2 1 1 0 1 1 1 1 PH domain SAP PF02037.27 ORX50557.1 - 1.1e-05 25.0 0.4 2e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 SAP domain SPX PF03105.19 ORX50557.1 - 6.3 6.6 12.5 9.8 6.0 12.5 1.3 1 1 0 1 1 1 0 SPX domain CBFD_NFYB_HMF PF00808.23 ORX50558.1 - 8.4e-16 58.0 1.1 1.2e-15 57.6 1.1 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX50558.1 - 1.7e-05 25.2 0.8 2.1e-05 24.9 0.8 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Cytochrom_B561 PF03188.16 ORX50559.1 - 1.1e-11 45.0 6.9 1.3e-11 44.8 6.9 1.1 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 YqhR PF11085.8 ORX50559.1 - 0.0057 16.6 2.2 0.0067 16.4 2.2 1.1 1 0 0 1 1 1 1 Conserved membrane protein YqhR DUF4149 PF13664.6 ORX50559.1 - 0.016 15.5 6.0 0.44 10.9 2.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4149) MgtC PF02308.16 ORX50559.1 - 0.018 15.4 1.7 0.031 14.6 1.7 1.6 1 1 0 1 1 1 0 MgtC family DUF4079 PF13301.6 ORX50559.1 - 0.024 14.8 6.7 0.091 12.9 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) Ferric_reduct PF01794.19 ORX50559.1 - 0.095 12.8 5.2 0.13 12.4 5.2 1.4 1 1 0 1 1 1 0 Ferric reductase like transmembrane component DUF3020 PF11223.8 ORX50560.1 - 2.2e-20 72.9 13.4 4.6e-20 71.9 13.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3020) DUF3187 PF11383.8 ORX50560.1 - 0.13 11.4 0.0 0.26 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3187) BAF250_C PF12031.8 ORX50561.1 - 4.3e-07 29.5 0.1 1.1e-06 28.2 0.1 1.7 1 0 0 1 1 1 1 SWI/SNF-like complex subunit BAF250/Osa DUF2336 PF10098.9 ORX50561.1 - 0.0023 17.4 0.0 0.17 11.3 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised protein conserved in bacteria (DUF2336) LEDGF PF11467.8 ORX50561.1 - 0.073 12.7 0.0 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) OrfB_Zn_ribbon PF07282.11 ORX50562.1 - 4.9e-05 23.2 0.3 5.8e-05 22.9 0.3 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DUF1658 PF07871.11 ORX50562.1 - 0.025 14.5 0.1 0.047 13.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) OrfB_Zn_ribbon PF07282.11 ORX50563.1 - 0.00019 21.3 1.9 0.00022 21.1 1.9 1.4 1 1 0 1 1 1 1 Putative transposase DNA-binding domain DUF1658 PF07871.11 ORX50563.1 - 0.04 13.9 0.2 0.11 12.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1658) TMEM154 PF15102.6 ORX50563.1 - 0.086 12.7 0.9 0.099 12.5 0.9 1.1 1 0 0 1 1 1 0 TMEM154 protein family p450 PF00067.22 ORX50564.1 - 8.4e-28 97.3 1.6 5e-27 94.8 1.6 2.0 1 1 0 1 1 1 1 Cytochrome P450 YrvL PF14184.6 ORX50564.1 - 0.013 15.6 0.1 3 8.0 0.0 2.3 2 0 0 2 2 2 0 Regulatory protein YrvL MIF4G PF02854.19 ORX50565.1 - 2.2e-46 158.2 0.1 5.8e-46 156.8 0.1 1.8 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 ORX50565.1 - 2.6e-07 30.6 2.2 6.7e-07 29.3 0.7 2.5 3 0 0 3 3 3 1 MA3 domain eIF_4G1 PF12152.8 ORX50565.1 - 0.0067 16.6 1.1 0.023 14.8 0.0 2.5 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 4G1 EF-hand_7 PF13499.6 ORX50566.1 - 8.5e-15 55.0 3.1 9.3e-07 29.2 1.3 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX50566.1 - 4.1e-13 48.1 5.1 9e-06 25.2 0.1 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ORX50566.1 - 7.3e-10 37.7 4.8 0.00062 19.1 0.7 3.6 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ORX50566.1 - 4.7e-09 36.0 9.7 3.4e-05 23.6 0.7 3.9 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ORX50566.1 - 3.5e-06 26.2 3.6 0.0047 16.4 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_11 PF08976.11 ORX50566.1 - 0.00086 20.1 0.1 0.0019 19.0 0.1 1.6 1 1 1 2 2 2 1 EF-hand domain GDPD PF03009.17 ORX50567.1 - 2.9e-30 105.9 0.0 7.9e-30 104.4 0.0 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD_2 PF13653.6 ORX50567.1 - 0.075 13.5 0.2 0.95 10.0 0.1 2.7 3 0 0 3 3 3 0 Glycerophosphoryl diester phosphodiesterase family TENA_THI-4 PF03070.16 ORX50568.1 - 0.0033 17.3 0.2 0.0058 16.5 0.2 1.5 1 0 0 1 1 1 1 TENA/THI-4/PQQC family COX1 PF00115.20 ORX50569.1 - 0.01 14.7 3.0 0.012 14.5 3.0 1.0 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I Cytochrom_B561 PF03188.16 ORX50569.1 - 0.026 14.6 0.4 0.053 13.7 0.1 1.6 2 0 0 2 2 2 0 Eukaryotic cytochrome b561 Phage_holin_3_6 PF07332.11 ORX50569.1 - 0.03 14.4 0.4 0.35 10.9 0.1 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4579 PF15158.6 ORX50569.1 - 0.057 13.2 0.1 0.065 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4579) DUF4059 PF13268.6 ORX50569.1 - 0.085 13.3 1.3 0.18 12.2 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4059) FAM209 PF15206.6 ORX50569.1 - 0.2 11.4 1.9 0.35 10.7 0.1 1.9 1 1 1 2 2 2 0 FAM209 family Wzy_C PF04932.15 ORX50569.1 - 2 8.0 6.3 12 5.5 6.3 1.9 1 1 0 1 1 1 0 O-Antigen ligase DUF202 PF02656.15 ORX50569.1 - 2 8.9 6.8 4.6 7.7 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF4381 PF14316.6 ORX50569.1 - 5.8 7.1 10.7 0.11 12.8 1.3 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4381) Muskelin_N PF06588.11 ORX50570.1 - 3.1e-70 236.2 0.6 4.8e-70 235.5 0.6 1.3 1 0 0 1 1 1 1 Muskelin N-terminus Kelch_4 PF13418.6 ORX50570.1 - 6.7e-22 77.2 3.2 0.0008 19.4 0.0 6.1 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX50570.1 - 9.8e-19 67.2 6.1 1.3e-05 25.3 0.0 6.2 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX50570.1 - 1e-18 66.9 5.0 4.2e-05 23.4 0.0 6.1 6 0 0 6 6 6 4 Kelch motif Kelch_6 PF13964.6 ORX50570.1 - 2.9e-16 59.1 9.0 0.001 19.3 0.0 6.4 6 1 0 6 6 6 4 Kelch motif Kelch_1 PF01344.25 ORX50570.1 - 4.2e-14 51.8 12.2 2e-06 27.3 0.0 6.3 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ORX50570.1 - 7.1e-10 38.5 3.0 0.0076 16.2 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Sad1_UNC PF07738.13 ORX50570.1 - 0.004 17.2 0.1 0.0084 16.1 0.1 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal F5_F8_type_C PF00754.25 ORX50570.1 - 0.011 15.9 3.4 0.026 14.7 0.0 3.0 3 1 1 4 4 4 0 F5/8 type C domain Zn_clus PF00172.18 ORX50571.1 - 7.8e-11 41.9 12.5 1.1e-10 41.5 12.5 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain BAG PF02179.16 ORX50572.1 - 2.1e-13 50.5 0.7 4.8e-13 49.3 0.7 1.6 1 1 0 1 1 1 1 BAG domain V-SNARE PF05008.15 ORX50572.1 - 0.13 12.6 0.5 8.6 6.8 0.1 2.2 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus ResIII PF04851.15 ORX50573.1 - 3.1e-14 53.3 0.0 9.3e-14 51.8 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX50573.1 - 1.6e-12 47.8 0.1 4e-12 46.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX50573.1 - 0.0017 18.1 0.0 0.006 16.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ORX50573.1 - 0.0069 16.1 0.1 0.022 14.4 0.0 1.8 2 0 0 2 2 2 1 SWI2/SNF2 ATPase BioT2 PF15368.6 ORX50573.1 - 0.13 12.2 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Spermatogenesis family BioT2 zf-CCHC PF00098.23 ORX50576.1 - 4.1e-05 23.5 4.3 8.7e-05 22.4 4.3 1.6 1 0 0 1 1 1 1 Zinc knuckle Pep1_7 PF17232.2 ORX50577.1 - 0.99 9.9 0.0 0.99 9.9 0.0 2.9 2 1 1 3 3 3 0 Elicitor peptide 1-7 zf-UBP PF02148.19 ORX50578.1 - 7.3e-08 32.6 2.1 1e-07 32.2 2.1 1.3 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein AATase PF07247.12 ORX50579.1 - 1.8e-17 63.1 0.0 1.2e-16 60.4 0.0 2.0 1 1 0 1 1 1 1 Alcohol acetyltransferase Filament PF00038.21 ORX50580.1 - 0.93 9.0 46.2 0.13 11.9 2.3 3.4 2 1 0 2 2 2 0 Intermediate filament protein ATG16 PF08614.11 ORX50580.1 - 1.4 9.1 65.3 32 4.7 23.9 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 ORX50580.1 - 1.8 6.0 47.6 2.4 5.5 47.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DBD_HTH PF18430.1 ORX50580.1 - 3.1 7.7 5.7 4.6 7.1 1.7 3.1 2 0 0 2 2 2 0 Putative DNA-binding domain DUF2703 PF10865.8 ORX50580.1 - 6.3 7.0 8.8 1.6 8.9 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2703) NAD_binding_10 PF13460.6 ORX50581.1 - 4.1e-19 69.2 0.0 5.4e-19 68.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX50581.1 - 9e-19 68.0 0.0 1.2e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 ORX50581.1 - 9e-05 22.7 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain Epimerase PF01370.21 ORX50581.1 - 0.0049 16.4 0.1 0.032 13.7 0.0 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 ORX50581.1 - 0.012 15.7 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase adh_short PF00106.25 ORX50581.1 - 0.019 14.4 0.1 0.051 13.0 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase 3Beta_HSD PF01073.19 ORX50581.1 - 0.021 13.8 0.3 0.033 13.2 0.3 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Sacchrp_dh_NADP PF03435.18 ORX50581.1 - 0.027 14.7 0.1 0.093 13.0 0.0 1.9 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain THF_DHG_CYH_C PF02882.19 ORX50581.1 - 0.029 13.7 0.0 0.075 12.4 0.0 1.7 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_2 PF03446.15 ORX50581.1 - 0.085 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Polysacc_synt_2 PF02719.15 ORX50581.1 - 0.18 10.9 0.0 2.4 7.2 0.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein Semialdhyde_dh PF01118.24 ORX50581.1 - 0.2 12.1 0.4 0.49 10.9 0.5 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain EloA-BP1 PF15870.5 ORX50583.1 - 0.056 13.7 0.1 7.5 6.8 0.0 2.1 1 1 1 2 2 2 0 ElonginA binding-protein 1 DUF2150 PF09920.9 ORX50583.1 - 0.065 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2150) NAD_binding_10 PF13460.6 ORX50584.1 - 1.2e-16 61.2 0.0 1.6e-16 60.8 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX50584.1 - 2.1e-14 53.7 0.0 2.6e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 ORX50584.1 - 5.9e-06 26.5 0.0 1e-05 25.8 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 ORX50584.1 - 0.00028 21.3 0.0 0.0006 20.2 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Semialdhyde_dh PF01118.24 ORX50584.1 - 0.0018 18.7 0.1 0.0033 17.8 0.1 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Epimerase PF01370.21 ORX50584.1 - 0.0026 17.2 0.0 0.011 15.2 0.0 2.0 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ORX50584.1 - 0.0071 15.8 0.1 0.015 14.7 0.0 1.6 2 0 0 2 2 2 1 short chain dehydrogenase Shikimate_DH PF01488.20 ORX50584.1 - 0.014 15.5 0.0 0.025 14.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase THF_DHG_CYH_C PF02882.19 ORX50584.1 - 0.018 14.3 0.1 0.06 12.7 0.1 1.9 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ComS PF17584.2 ORX50584.1 - 0.031 13.8 0.0 0.099 12.2 0.0 1.8 1 0 0 1 1 1 0 Bacillus competence protein S Ribosomal_L1 PF00687.21 ORX50584.1 - 0.065 13.0 0.0 0.091 12.5 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L1p/L10e family NAD_binding_2 PF03446.15 ORX50584.1 - 0.074 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase HEAT PF02985.22 ORX50585.1 - 6.8e-11 41.5 0.1 0.26 11.6 0.0 5.8 5 0 0 5 5 5 2 HEAT repeat Pkinase PF00069.25 ORX50585.1 - 1.4e-09 37.7 0.0 2.2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50585.1 - 4e-07 29.6 0.0 6.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Cnd1 PF12717.7 ORX50585.1 - 3e-05 24.1 0.1 9.2e-05 22.5 0.1 1.8 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Kinase-like PF14531.6 ORX50585.1 - 3.7e-05 23.2 0.0 5.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like HEAT_2 PF13646.6 ORX50585.1 - 8.1e-05 22.9 0.0 0.0024 18.2 0.0 2.7 1 1 2 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ORX50585.1 - 0.0042 17.6 0.3 3.6 8.2 0.2 3.9 3 1 1 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 ORX50585.1 - 0.049 12.2 0.0 0.29 9.6 0.0 1.6 1 1 0 1 1 1 0 Adaptin N terminal region DUF3437 PF11919.8 ORX50585.1 - 0.09 12.7 0.0 0.75 9.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) ThiF PF00899.21 ORX50586.1 - 9.9e-22 77.5 0.0 1.8e-21 76.6 0.0 1.4 1 1 0 1 1 1 1 ThiF family E1_4HB PF16191.5 ORX50586.1 - 0.0035 17.5 0.1 0.68 10.2 0.0 3.3 4 0 0 4 4 4 1 Ubiquitin-activating enzyme E1 four-helix bundle Prolactin_RP PF15172.6 ORX50586.1 - 0.012 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 Prolactin-releasing peptide Hexokinase_2 PF03727.16 ORX50587.1 - 1.4e-80 270.2 0.1 2.4e-80 269.5 0.1 1.4 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX50587.1 - 3.8e-71 239.1 0.0 6.9e-71 238.3 0.0 1.4 1 0 0 1 1 1 1 Hexokinase DPPIV_N PF00930.21 ORX50588.1 - 1.1e-95 320.4 6.2 1.6e-95 319.9 6.2 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ORX50588.1 - 2.6e-34 118.6 0.6 4.9e-34 117.7 0.6 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ORX50588.1 - 1.4e-05 24.8 1.7 2.7e-05 23.9 1.7 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 ORX50588.1 - 6.3e-05 23.7 1.2 6.3e-05 23.7 1.2 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase family AXE1 PF05448.12 ORX50588.1 - 0.002 16.9 0.1 0.025 13.3 0.1 2.1 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 ORX50588.1 - 0.0027 17.4 0.6 0.0053 16.4 0.6 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX50588.1 - 0.017 14.4 0.1 0.03 13.6 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 LIP PF03583.14 ORX50588.1 - 0.083 12.2 0.5 0.42 9.9 0.2 2.0 2 0 0 2 2 2 0 Secretory lipase Enolase_C PF00113.22 ORX50589.1 - 5.8e-154 511.6 0.3 7.3e-154 511.3 0.3 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ORX50589.1 - 7.6e-57 191.1 0.3 1.4e-56 190.3 0.3 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ORX50589.1 - 0.00014 21.5 0.0 0.00022 20.9 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ORX50589.1 - 0.0046 16.2 0.3 0.0099 15.1 0.3 1.5 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus COPIIcoated_ERV PF07970.12 ORX50590.1 - 6.5e-69 232.1 0.2 8.5e-69 231.8 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ORX50590.1 - 8.7e-13 48.4 0.1 4.4e-12 46.2 0.0 2.1 2 0 0 2 2 2 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Pre-PUA PF17832.1 ORX50591.1 - 4.9e-28 97.6 0.1 7.2e-28 97.1 0.1 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 ORX50591.1 - 2.9e-20 72.0 0.0 4.2e-20 71.5 0.0 1.3 1 0 0 1 1 1 1 PUA domain BSD PF03909.17 ORX50591.1 - 0.11 12.5 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 BSD domain Sua5_yciO_yrdC PF01300.18 ORX50593.1 - 9.7e-55 184.8 0.0 1.4e-54 184.3 0.0 1.2 1 0 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 ORX50593.1 - 3.6e-30 105.3 0.0 6e-30 104.5 0.0 1.4 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding AGP PF06376.12 ORX50593.1 - 0.037 13.9 1.0 0.19 11.6 1.0 2.2 1 0 0 1 1 1 0 Arabinogalactan peptide Ion_trans PF00520.31 ORX50594.1 - 1e-05 24.9 10.5 1.4e-05 24.5 10.5 1.1 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ORX50594.1 - 0.0012 17.7 3.4 0.0015 17.3 3.4 1.2 1 0 0 1 1 1 1 Polycystin cation channel DUF805 PF05656.14 ORX50594.1 - 0.099 13.1 6.6 0.16 12.4 6.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF805) DUF3742 PF12553.8 ORX50594.1 - 0.14 12.3 0.5 0.44 10.7 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3742) DnaJ PF00226.31 ORX50595.1 - 1e-17 64.0 0.8 2.8e-17 62.6 0.8 1.8 1 0 0 1 1 1 1 DnaJ domain RAC_head PF16717.5 ORX50595.1 - 4.7e-13 49.9 7.0 4.7e-13 49.9 7.0 3.4 4 0 0 4 4 4 1 Ribosome-associated complex head domain Rnk_N PF14760.6 ORX50595.1 - 0.32 11.5 3.5 1.1 9.8 2.5 2.5 2 0 0 2 2 2 0 Rnk N-terminus LMBR1 PF04791.16 ORX50595.1 - 1.7 7.5 3.5 1.8 7.4 3.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CT47 PF15623.6 ORX50595.1 - 5.8 6.7 20.7 0.39 10.5 15.5 1.7 2 0 0 2 2 2 0 Cancer/testis gene family 47 O-antigen_lig PF13425.6 ORX50595.1 - 7.3 5.3 6.7 12 4.5 6.7 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Mito_carr PF00153.27 ORX50596.1 - 1.2e-65 217.4 4.0 5e-22 77.6 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PSI_PsaE PF02427.17 ORX50596.1 - 0.023 14.4 0.0 0.048 13.3 0.0 1.5 1 0 0 1 1 1 0 Photosystem I reaction centre subunit IV / PsaE THUMP PF02926.17 ORX50597.1 - 5.1e-12 46.1 0.0 2.7e-11 43.7 0.0 1.9 1 1 1 2 2 2 1 THUMP domain Hydrolase_4 PF12146.8 ORX50598.1 - 1.7e-11 43.8 0.0 7.3e-08 32.0 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ORX50598.1 - 3.6e-09 36.4 0.0 5.6e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ORX50598.1 - 2.8e-08 33.7 0.2 0.00012 21.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 ORX50598.1 - 0.00021 21.0 0.0 0.00032 20.4 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 ORX50598.1 - 0.0006 18.6 1.1 0.26 9.9 0.0 2.9 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ORX50598.1 - 0.00068 20.3 0.0 0.0018 18.9 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ORX50598.1 - 0.0012 18.5 0.0 0.0096 15.5 0.0 1.9 2 0 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 ORX50598.1 - 0.0057 16.2 0.0 0.027 14.0 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ORX50598.1 - 0.019 14.9 0.0 3.4 7.5 0.0 2.2 1 1 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_2 PF02230.16 ORX50598.1 - 0.025 14.4 0.2 2.1 8.1 0.2 2.2 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DUF818 PF05677.12 ORX50598.1 - 0.072 12.0 0.0 0.1 11.5 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) 3HBOH PF10605.9 ORX50598.1 - 0.073 11.3 0.0 0.1 10.8 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) Acetyltransf_1 PF00583.25 ORX50599.1 - 0.0016 18.7 0.0 0.0021 18.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 ORX50599.1 - 0.0027 17.8 0.0 0.0039 17.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX50599.1 - 0.073 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein CAP_GLY PF01302.25 ORX50600.1 - 2e-15 56.5 0.1 4e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 ORX50600.1 - 1.5e-10 40.7 15.4 4.9e-05 23.1 6.6 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle HAP1_N PF04849.13 ORX50600.1 - 2.6e-05 23.6 12.9 2.6e-05 23.6 12.9 5.8 4 2 1 5 5 5 2 HAP1 N-terminal conserved region ATG16 PF08614.11 ORX50600.1 - 0.0006 20.1 11.7 0.0006 20.1 11.7 7.4 2 1 3 6 6 6 3 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 ORX50600.1 - 0.0035 16.9 17.3 0.0035 16.9 17.3 6.8 2 2 4 6 6 6 2 Golgin subfamily A member 5 tRNA_bind PF01588.20 ORX50602.1 - 6.6e-28 96.7 0.1 9.2e-28 96.2 0.1 1.2 1 0 0 1 1 1 1 Putative tRNA binding domain Glycos_transf_2 PF00535.26 ORX50604.1 - 0.0042 16.9 0.1 0.093 12.5 0.1 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Kelch_5 PF13854.6 ORX50605.1 - 4.2e-10 39.4 5.7 0.0084 16.1 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ORX50605.1 - 1.4e-09 38.0 9.8 0.0011 19.1 0.0 4.3 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX50605.1 - 3.3e-09 36.7 5.4 0.00039 20.6 0.1 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ORX50605.1 - 1.6e-08 34.0 9.0 0.0011 18.5 0.6 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ORX50605.1 - 2e-08 34.1 8.9 0.0077 16.2 0.1 3.9 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX50605.1 - 4.2e-08 32.9 7.5 0.0012 18.7 0.2 3.4 3 0 0 3 3 3 2 Kelch motif Fungal_trans PF04082.18 ORX50606.1 - 6.7e-21 74.5 2.6 6.7e-21 74.5 2.6 2.6 2 1 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX50606.1 - 2.6e-07 30.6 7.9 5e-07 29.7 7.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SR-25 PF10500.9 ORX50606.1 - 2.5 7.6 21.3 0.83 9.2 1.9 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein SAGA-Tad1 PF12767.7 ORX50606.1 - 3.9 7.1 13.2 0.3 10.8 4.5 2.3 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit bZIP_Maf PF03131.17 ORX50606.1 - 9.8 6.8 16.5 3.7 8.1 0.1 3.5 3 0 0 3 3 3 0 bZIP Maf transcription factor AMP-binding PF00501.28 ORX50607.1 - 1.3e-86 290.9 0.0 1.6e-86 290.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX50607.1 - 1.2e-20 74.3 0.1 3.3e-20 72.8 0.1 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain GH3 PF03321.13 ORX50607.1 - 0.01 14.8 0.0 0.087 11.7 0.0 2.0 2 0 0 2 2 2 0 GH3 auxin-responsive promoter Molybdop_Fe4S4 PF04879.16 ORX50607.1 - 0.17 11.9 0.5 0.38 10.8 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain Uso1_p115_C PF04871.13 ORX50803.1 - 8.5 6.8 7.1 13 6.2 7.1 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region G-gamma PF00631.22 ORX50804.1 - 2.2e-18 66.0 0.6 2.6e-18 65.8 0.6 1.1 1 0 0 1 1 1 1 GGL domain KIAA1430 PF13879.6 ORX50804.1 - 0.0053 17.5 0.1 0.0053 17.5 0.1 1.1 1 0 0 1 1 1 1 KIAA1430 homologue DUF5420 PF17457.2 ORX50804.1 - 0.13 12.1 0.0 0.15 11.9 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5420) OppC_N PF12911.7 ORX50805.1 - 8.6 6.4 6.4 0.33 10.9 0.6 1.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Methyltransf_25 PF13649.6 ORX50806.1 - 1.3e-13 51.4 0.0 3.5e-13 50.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX50806.1 - 2.5e-13 50.1 0.1 7.1e-13 48.6 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX50806.1 - 1.3e-11 44.5 0.0 1.8e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ORX50806.1 - 2.2e-11 44.3 0.0 7.8e-11 42.5 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ORX50806.1 - 1e-08 34.5 0.5 1.5e-08 34.0 0.2 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1698) CMAS PF02353.20 ORX50806.1 - 2.1e-08 33.8 0.2 2.9e-08 33.3 0.2 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ORX50806.1 - 2.6e-07 30.6 0.0 5e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX50806.1 - 5.6e-07 30.2 0.0 1.2e-06 29.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX50806.1 - 8.7e-06 25.4 0.1 1.5e-05 24.7 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ORX50806.1 - 1.3e-05 25.2 0.1 2.2e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX50806.1 - 0.0001 21.7 0.1 0.00019 20.8 0.1 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 ORX50806.1 - 0.00025 20.5 0.4 0.00062 19.2 0.3 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PRMT5 PF05185.16 ORX50806.1 - 0.00025 20.9 0.1 0.00039 20.3 0.1 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Met_10 PF02475.16 ORX50806.1 - 0.00043 20.1 0.1 0.00063 19.5 0.1 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.6 ORX50806.1 - 0.0012 18.9 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ORX50806.1 - 0.0043 17.2 0.0 0.01 16.0 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase PCMT PF01135.19 ORX50806.1 - 0.0055 16.5 0.5 0.012 15.4 0.2 1.7 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 ORX50806.1 - 0.011 16.8 0.0 0.02 15.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ORX50806.1 - 0.015 14.7 0.6 0.047 13.1 0.6 1.8 1 1 0 1 1 1 0 Tellurite resistance protein TehB Cons_hypoth95 PF03602.15 ORX50806.1 - 0.039 13.6 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_16 PF10294.9 ORX50806.1 - 0.057 13.1 0.1 0.086 12.6 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase UPF0020 PF01170.18 ORX50806.1 - 0.077 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 ORX50806.1 - 0.079 12.5 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase WD40 PF00400.32 ORX50807.1 - 1.3e-11 44.9 14.1 0.00037 21.2 0.7 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX50807.1 - 0.0029 17.9 0.1 4.2 7.7 0.0 3.9 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain LisH_2 PF16045.5 ORX50807.1 - 0.01 14.8 1.5 0.33 10.0 0.1 2.5 2 0 0 2 2 2 0 LisH PliI PF16743.5 ORX50807.1 - 0.036 13.8 0.0 0.087 12.6 0.0 1.6 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme LisH PF08513.11 ORX50807.1 - 0.055 13.4 2.1 7 6.8 0.6 2.4 2 0 0 2 2 2 0 LisH Velvet PF11754.8 ORX50808.1 - 9.9e-31 107.6 1.1 7.2e-30 104.7 0.7 1.9 1 1 1 2 2 2 1 Velvet factor BAG PF02179.16 ORX50809.1 - 1.4e-09 38.2 1.0 1.4e-09 38.2 1.0 2.3 2 2 0 2 2 2 1 BAG domain HemY_N PF07219.13 ORX50809.1 - 1.3 9.3 8.7 1.7 8.9 7.5 1.8 1 1 0 1 1 1 0 HemY protein N-terminus PulG PF11773.8 ORX50809.1 - 3 7.7 4.3 5.4 6.9 2.9 2.1 2 0 0 2 2 2 0 Type II secretory pathway pseudopilin Ubiquitin_4 PF18036.1 ORX50810.1 - 3e-19 68.9 0.0 4.9e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 ORX50810.1 - 0.0026 17.5 0.1 0.0059 16.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX50810.1 - 0.055 13.2 1.6 0.47 10.3 1.1 2.5 1 1 0 1 1 1 0 Ubiquitin family PEPCK_ATP PF01293.20 ORX50811.1 - 3.7e-221 734.7 0.0 4.3e-221 734.5 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 ORX50811.1 - 0.14 12.5 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain MRFAP1 PF15155.6 ORX50811.1 - 0.17 12.4 0.0 0.28 11.7 0.0 1.3 1 0 0 1 1 1 0 MORF4 family-associated protein1 HORMA PF02301.18 ORX50812.1 - 3e-07 30.2 0.3 4.7e-07 29.6 0.3 1.4 1 1 0 1 1 1 1 HORMA domain Gti1_Pac2 PF09729.9 ORX50813.1 - 4.8e-46 157.1 3.0 7.8e-40 136.9 0.3 2.0 1 1 1 2 2 2 2 Gti1/Pac2 family zf-C3HC4_3 PF13920.6 ORX50814.1 - 2.6e-12 46.4 14.0 2.6e-12 46.4 14.0 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX50814.1 - 0.00014 22.1 14.7 0.00014 22.1 14.7 2.1 2 1 0 2 2 2 1 Ring finger domain FYVE PF01363.21 ORX50814.1 - 0.0035 17.5 2.1 0.0035 17.5 2.1 3.1 2 1 0 2 2 2 1 FYVE zinc finger zf-C3HC4_2 PF13923.6 ORX50814.1 - 0.0087 15.9 16.8 0.0087 15.9 16.8 2.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_2 PF13240.6 ORX50814.1 - 0.025 14.3 0.8 0.025 14.3 0.8 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DUF4518 PF15008.6 ORX50814.1 - 0.08 12.1 0.9 0.64 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) Armet PF10208.9 ORX50814.1 - 0.15 12.0 9.4 1.4 8.9 0.1 3.1 2 1 1 3 3 3 0 Degradation arginine-rich protein for mis-folding MDM31_MDM32 PF08118.11 ORX50815.1 - 3.9e-164 547.2 0.0 1.4e-163 545.4 0.0 1.7 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins Transglut_core PF01841.19 ORX50816.1 - 0.15 12.5 0.1 0.82 10.2 0.1 2.1 2 0 0 2 2 2 0 Transglutaminase-like superfamily Ndc80_HEC PF03801.13 ORX50817.1 - 4.3e-33 114.1 0.0 1.3e-32 112.6 0.0 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 ORX50817.1 - 5.2e-10 39.3 0.6 5.2e-10 39.3 0.6 4.1 3 1 1 4 4 4 1 Domain of unknown function (DUF5595) DUF1454 PF07305.12 ORX50817.1 - 0.012 15.1 5.1 0.027 13.9 4.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1454) DHR10 PF18595.1 ORX50817.1 - 0.019 15.0 3.2 0.019 15.0 3.2 4.1 3 1 0 4 4 4 0 Designed helical repeat protein 10 domain ERM PF00769.19 ORX50817.1 - 2.5 7.9 39.0 0.013 15.3 17.6 2.4 2 1 1 3 3 3 0 Ezrin/radixin/moesin family Spc7 PF08317.11 ORX50817.1 - 8.8 5.1 41.2 0.051 12.5 16.5 2.9 2 1 1 3 3 3 0 Spc7 kinetochore protein Myb_Cef PF11831.8 ORX50819.1 - 2e-51 174.9 6.8 2e-51 174.9 6.8 4.0 4 0 0 4 4 4 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 ORX50819.1 - 6.9e-22 77.4 4.6 5e-11 42.6 1.2 2.8 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX50819.1 - 1.5e-20 73.2 6.5 2.8e-13 49.9 3.6 3.0 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 ORX50819.1 - 0.16 12.0 3.0 0.39 10.8 0.0 3.1 3 1 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain PSCyt3 PF07627.11 ORX50820.1 - 0.064 13.5 0.3 0.15 12.3 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1588) ACPS PF01648.20 ORX50821.1 - 2.1e-14 53.6 0.0 3.5e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily UBD PF16455.5 ORX50822.1 - 2.6e-33 114.4 0.0 3.8e-33 113.9 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-binding domain DUF2407 PF10302.9 ORX50822.1 - 1.4e-05 25.6 0.0 2.2e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX50822.1 - 0.067 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX50822.1 - 0.094 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin family MDM10 PF12519.8 ORX50823.1 - 1.1e-91 308.1 7.3 6.1e-84 282.5 7.0 2.6 1 1 1 2 2 2 2 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 ORX50823.1 - 0.0024 17.4 0.2 0.02 14.4 0.0 2.2 1 1 0 2 2 2 1 Eukaryotic porin Cpn60_TCP1 PF00118.24 ORX50826.1 - 5.8e-150 500.2 18.1 6.6e-150 500.0 18.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sua5_yciO_yrdC PF01300.18 ORX50826.1 - 0.00019 21.0 0.1 0.0011 18.5 0.0 2.1 2 0 0 2 2 2 1 Telomere recombination SCAB_CC PF16712.5 ORX50826.1 - 0.0054 16.6 1.6 0.0071 16.2 0.2 1.9 2 0 0 2 2 2 1 Coiled-coil regions of plant-specific actin-binding protein eRF1_2 PF03464.15 ORX50827.1 - 1.9e-44 151.2 0.1 3.1e-44 150.5 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ORX50827.1 - 7.3e-38 129.5 0.0 1.4e-37 128.6 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 ORX50827.1 - 6.7e-22 77.9 0.0 1.2e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 ORX50827.1 - 7.3e-09 36.0 0.0 1.1e-08 35.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 ORX50827.1 - 4.7e-08 33.4 0.0 8.9e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor DUF3440 PF11922.8 ORX50827.1 - 0.15 11.7 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) FMO-like PF00743.19 ORX50828.1 - 5e-10 38.4 0.2 0.00025 19.6 0.0 3.1 2 1 1 3 3 3 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 ORX50828.1 - 3.1e-06 27.3 0.0 8.1e-06 26.0 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX50828.1 - 0.00033 20.0 0.1 1.3 8.1 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX50828.1 - 0.002 17.4 0.6 0.086 12.0 0.0 2.9 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 ORX50828.1 - 0.011 14.9 0.2 1.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ORX50828.1 - 0.011 15.0 1.3 0.29 10.3 0.0 3.1 4 0 0 4 4 4 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX50828.1 - 0.029 14.4 0.1 12 5.9 0.0 2.8 3 0 0 3 3 3 0 FAD-NAD(P)-binding RBD-FIP PF09457.10 ORX50829.1 - 0.019 14.9 0.1 0.019 14.9 0.1 3.6 4 0 0 4 4 4 0 FIP domain UPF0242 PF06785.11 ORX50829.1 - 0.044 13.9 25.3 0.027 14.6 3.7 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 ORX50829.1 - 2 9.0 17.9 2.3 8.8 2.0 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 FlaC_arch PF05377.11 ORX50829.1 - 2.5 8.6 5.8 14 6.2 0.8 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF1974 PF09317.11 ORX50829.1 - 3.7 7.0 8.3 0.19 11.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) Fez1 PF06818.15 ORX50829.1 - 4.3 7.7 33.4 1.1 9.7 18.4 2.6 1 1 0 2 2 2 0 Fez1 CENP-H PF05837.12 ORX50829.1 - 4.9 7.6 24.6 1.3 9.4 1.7 2.9 2 2 1 3 3 3 0 Centromere protein H (CENP-H) Atg14 PF10186.9 ORX50829.1 - 7.1 5.6 26.8 0.035 13.2 13.2 2.2 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Vps54 PF07928.12 ORX50830.1 - 6.1e-49 165.9 0.2 1.9e-48 164.3 0.2 1.9 1 0 0 1 1 1 1 Vps54-like protein Vps54_N PF10475.9 ORX50830.1 - 3.3e-10 39.7 0.5 9.2e-10 38.3 0.1 1.9 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 ORX50830.1 - 3.6e-09 36.8 0.8 1.4e-08 34.8 0.8 2.0 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) COG5 PF10392.9 ORX50830.1 - 0.035 14.3 0.8 0.1 12.7 0.3 2.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 LOH1CR12 PF10158.9 ORX50830.1 - 0.52 10.3 6.8 10 6.2 0.1 3.6 3 0 0 3 3 3 0 Tumour suppressor protein OrfB_Zn_ribbon PF07282.11 ORX50831.1 - 7.2e-10 38.6 2.5 1.3e-09 37.8 2.5 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX50831.1 - 0.066 12.9 0.8 0.12 12.0 0.8 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal DUF4503 PF14951.6 ORX50831.1 - 0.38 9.2 2.4 0.61 8.5 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) HECT PF00632.25 ORX50832.1 - 5.2e-95 318.5 0.0 1.2e-94 317.3 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) DUF913 PF06025.12 ORX50832.1 - 6.4e-89 298.5 1.3 6.4e-89 298.5 1.3 9.0 7 2 0 7 7 7 1 Domain of Unknown Function (DUF913) DUF908 PF06012.12 ORX50832.1 - 2.2e-59 201.7 0.5 9.3e-36 124.0 0.4 6.8 6 2 2 8 8 8 2 Domain of Unknown Function (DUF908) UBM PF14377.6 ORX50832.1 - 8.8e-18 63.1 18.3 3.2e-09 35.9 0.6 3.7 3 0 0 3 3 3 2 Ubiquitin binding region UBA PF00627.31 ORX50832.1 - 1.8e-06 27.7 0.1 1.8e-06 27.7 0.1 2.2 2 0 0 2 2 2 1 UBA/TS-N domain DUF4042 PF13251.6 ORX50832.1 - 0.12 12.0 0.2 0.55 9.9 0.2 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) DUF3020 PF11223.8 ORX50833.1 - 3.3e-17 62.7 5.2 3.3e-17 62.7 5.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3020) zf-C2H2 PF00096.26 ORX50833.1 - 1.1e-05 25.6 0.9 2.2e-05 24.6 0.9 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX50833.1 - 0.00014 22.4 1.7 0.00025 21.6 0.4 2.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX50833.1 - 0.0037 17.5 0.3 0.011 16.1 0.3 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX50833.1 - 0.0056 16.4 3.7 0.017 14.9 3.7 1.8 1 1 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 ORX50833.1 - 0.015 15.6 0.6 0.026 14.9 0.6 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 ORX50833.1 - 0.051 14.0 2.7 0.055 13.9 0.4 2.1 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 ORX50833.1 - 0.055 13.4 0.2 0.055 13.4 0.2 2.1 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-RING_2 PF13639.6 ORX50834.1 - 1e-11 44.9 5.8 1.6e-11 44.4 5.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX50834.1 - 8.4e-10 38.3 7.1 1.4e-09 37.6 7.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX50834.1 - 6.9e-09 35.9 4.1 1.6e-08 34.7 4.1 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ORX50834.1 - 2.2e-06 27.4 3.5 3.4e-06 26.8 3.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX50834.1 - 2.7e-06 27.3 3.5 5e-06 26.4 3.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 ORX50834.1 - 6.6e-06 25.8 0.9 1.4e-05 24.7 0.9 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX50834.1 - 1.2e-05 25.1 5.6 2e-05 24.3 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX50834.1 - 4.4e-05 23.3 4.2 7.8e-05 22.5 4.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ORX50834.1 - 0.00068 19.5 4.7 0.002 18.1 5.0 1.7 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX50834.1 - 0.0014 18.6 4.3 0.0047 17.0 4.3 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 ORX50834.1 - 0.0024 17.9 3.4 0.0044 17.1 3.4 1.4 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-C3HC4_4 PF15227.6 ORX50834.1 - 0.047 13.9 4.1 0.13 12.5 4.1 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 ORX50834.1 - 0.28 10.9 3.1 0.46 10.1 3.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-P11 PF03854.14 ORX50834.1 - 0.71 9.6 3.5 1.4 8.6 1.8 2.0 1 1 1 2 2 2 0 P-11 zinc finger zf-RING_4 PF14570.6 ORX50834.1 - 1 9.2 5.2 1.8 8.5 5.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 ORX50834.1 - 2.6 8.0 6.0 4.6 7.2 2.2 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Gpr1_Fun34_YaaH PF01184.19 ORX50835.1 - 9e-74 247.5 19.5 1.1e-73 247.3 19.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Keratin PF02422.16 ORX50835.1 - 0.2 11.4 1.1 0.38 10.5 1.1 1.4 1 0 0 1 1 1 0 Keratin Gpr1_Fun34_YaaH PF01184.19 ORX50836.1 - 1e-75 253.9 15.8 1.2e-75 253.6 15.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 ORX50837.1 - 1.1e-63 214.6 16.5 1.3e-63 214.4 16.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family DUF5090 PF17009.5 ORX50837.1 - 0.94 9.4 3.5 1.7 8.6 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) RNase_P_p30 PF01876.16 ORX50839.1 - 8.1e-26 90.8 0.0 8.9e-26 90.7 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 SSF PF00474.17 ORX50841.1 - 1.3e-19 70.4 34.1 1.3e-19 70.4 34.1 1.6 2 0 0 2 2 2 1 Sodium:solute symporter family Ribonuclease_T2 PF00445.18 ORX50842.1 - 3.9e-34 118.5 0.0 4.6e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family PGM_PMM_I PF02878.16 ORX50843.1 - 6.5e-36 123.1 0.0 1.3e-35 122.1 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ORX50843.1 - 6.6e-23 81.3 0.0 1.7e-22 80.0 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ORX50843.1 - 8.9e-13 48.4 0.1 1.6e-12 47.6 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 ORX50843.1 - 2e-06 27.9 0.0 4.8e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain CTP_transf_like PF01467.26 ORX50844.1 - 2.3e-41 141.3 0.0 6.6e-25 88.0 0.0 2.2 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 ORX50844.1 - 0.0033 17.3 0.4 2.1 8.2 0.0 3.0 3 0 0 3 3 3 2 FAD synthetase Pantoate_ligase PF02569.15 ORX50844.1 - 0.016 14.5 0.0 1 8.5 0.0 2.2 2 0 0 2 2 2 0 Pantoate-beta-alanine ligase ScdA_N PF04405.14 ORX50844.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown function (DUF542) Thioredoxin PF00085.20 ORX50846.1 - 1.9e-69 230.2 2.9 1.6e-34 117.9 0.1 4.3 4 0 0 4 4 4 4 Thioredoxin Thioredoxin_6 PF13848.6 ORX50846.1 - 5.1e-48 163.4 1.0 2.5e-35 122.1 0.2 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ORX50846.1 - 1.1e-10 41.5 1.4 0.00087 19.4 0.0 3.9 4 1 0 4 4 4 2 Thioredoxin-like Thioredoxin_8 PF13905.6 ORX50846.1 - 7.7e-10 39.0 0.1 0.012 15.9 0.0 4.3 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 ORX50846.1 - 5.2e-09 36.5 5.4 0.0026 18.2 0.2 4.2 2 2 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 ORX50846.1 - 1.5e-08 34.4 0.1 0.00024 20.6 0.0 2.9 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family ERp29_N PF07912.13 ORX50846.1 - 3.9e-07 30.3 1.2 1.1 9.4 0.0 4.7 4 1 1 5 5 5 3 ERp29, N-terminal domain Calsequestrin PF01216.17 ORX50846.1 - 2.3e-06 26.9 3.0 2.3e-06 26.9 3.0 1.8 2 1 0 2 2 2 1 Calsequestrin AhpC-TSA PF00578.21 ORX50846.1 - 0.00011 22.1 0.6 0.29 11.1 0.2 3.2 2 1 0 2 2 2 2 AhpC/TSA family Thioredoxin_5 PF13743.6 ORX50846.1 - 0.00024 20.8 2.0 0.96 9.1 0.0 4.2 3 2 2 5 5 5 2 Thioredoxin Thioredoxin_3 PF13192.6 ORX50846.1 - 0.0009 19.3 0.3 0.031 14.3 0.0 3.0 4 0 0 4 4 3 1 Thioredoxin domain Thioredoxin_9 PF14595.6 ORX50846.1 - 0.0012 18.6 0.1 0.26 11.1 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin HyaE PF07449.11 ORX50846.1 - 0.0093 15.9 0.5 1.2 9.2 0.0 4.3 3 2 0 4 4 4 1 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 ORX50846.1 - 0.011 15.4 0.3 2.2 8.0 0.1 2.7 2 0 0 2 2 2 0 Redoxin Ribonuc_P_40 PF08584.11 ORX50847.1 - 2.3e-44 151.8 0.0 3.1e-44 151.4 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit MutS_V PF00488.21 ORX50848.1 - 4.2e-77 258.5 0.0 7e-77 257.7 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX50848.1 - 2.3e-26 93.2 12.3 6.9e-26 91.6 10.9 2.5 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 ORX50848.1 - 5e-25 88.0 0.1 1.2e-24 86.7 0.0 1.7 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 ORX50848.1 - 8.1e-11 42.4 0.0 9.3e-10 38.9 0.0 2.7 4 0 0 4 4 4 1 MutS domain II AAA_29 PF13555.6 ORX50848.1 - 0.12 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 ORX50849.1 - 0.018 15.9 0.4 4.6 8.3 0.0 3.8 3 0 0 3 3 3 0 WD domain, G-beta repeat GTP_EFTU PF00009.27 ORX50850.1 - 6.4e-66 221.6 0.1 9e-66 221.1 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX50850.1 - 1.3e-31 108.9 0.0 3.9e-31 107.3 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ORX50850.1 - 1.4e-21 76.3 0.0 3.5e-21 75.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ORX50850.1 - 3.6e-13 49.4 0.0 8.2e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ORX50850.1 - 1.8e-11 44.3 0.1 5e-11 42.8 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX50850.1 - 4.8e-05 23.4 0.1 9.9e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ORX50850.1 - 0.00071 19.3 0.0 0.0023 17.7 0.0 1.8 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Nuc_sug_transp PF04142.15 ORX50851.1 - 1.6e-73 247.6 4.3 1.8e-73 247.5 4.3 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ORX50851.1 - 3.1e-07 30.6 11.6 2.6e-06 27.7 2.6 2.2 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ORX50851.1 - 0.00013 21.3 3.6 0.00016 21.0 3.6 1.3 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport UAA PF08449.11 ORX50851.1 - 0.00045 19.5 3.6 0.0011 18.3 3.6 1.7 1 1 0 1 1 1 1 UAA transporter family EmrE PF13536.6 ORX50851.1 - 0.00059 19.5 0.3 0.00093 18.9 0.3 1.4 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter TPT PF03151.16 ORX50851.1 - 0.0088 15.4 1.9 0.0088 15.4 1.9 2.1 2 1 0 2 2 2 1 Triose-phosphate Transporter family DUF1640 PF07798.11 ORX50853.1 - 4e-48 163.8 7.8 6.3e-48 163.1 7.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) Peptidase_M56 PF05569.11 ORX50853.1 - 0.058 12.6 0.2 0.085 12.0 0.2 1.3 1 0 0 1 1 1 0 BlaR1 peptidase M56 DUF5358 PF17311.2 ORX50853.1 - 0.063 13.3 2.0 0.14 12.2 2.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5358) Gtr1_RagA PF04670.12 ORX50854.1 - 6.7e-101 336.5 0.1 8.2e-101 336.2 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ORX50854.1 - 1.4e-09 37.6 0.2 3.5e-09 36.3 0.0 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 ORX50854.1 - 8.8e-09 35.6 0.0 1.9e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX50854.1 - 7.7e-08 32.1 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ORX50854.1 - 5.6e-07 29.6 0.0 9.8e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX50854.1 - 0.0013 18.4 0.0 0.0038 16.8 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX50854.1 - 0.0015 18.4 0.1 1.3 8.9 0.1 2.6 2 0 0 2 2 2 2 RsgA GTPase PduV-EutP PF10662.9 ORX50854.1 - 0.014 15.1 0.3 0.085 12.6 0.1 2.3 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ORX50854.1 - 0.024 15.2 0.3 0.063 13.8 0.1 1.7 2 1 0 2 2 2 0 ABC transporter SRPRB PF09439.10 ORX50854.1 - 0.029 13.8 0.1 0.054 12.9 0.0 1.5 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF815 PF05673.13 ORX50854.1 - 0.039 13.1 0.5 0.14 11.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_24 PF13479.6 ORX50854.1 - 0.097 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 ORX50854.1 - 0.55 9.3 5.5 7.9 5.5 0.1 2.6 2 1 1 3 3 3 0 G-protein alpha subunit MFMR PF07777.11 ORX50856.1 - 0.23 12.0 6.1 0.072 13.6 3.0 1.7 1 1 1 2 2 2 0 G-box binding protein MFMR UCH PF00443.29 ORX50857.1 - 2.7e-05 23.8 0.0 4.3e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Spc24 PF08286.11 ORX50857.1 - 0.033 14.4 0.1 0.35 11.1 0.0 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 TolA_bind_tri PF16331.5 ORX50857.1 - 0.38 10.9 7.1 0.093 12.8 0.9 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation SlyX PF04102.12 ORX50857.1 - 3.9 8.2 6.7 8.4 7.1 0.4 2.7 2 0 0 2 2 2 0 SlyX STIMATE PF12400.8 ORX50860.1 - 5.2e-39 133.6 11.0 9.3e-39 132.8 11.0 1.4 1 0 0 1 1 1 1 STIMATE family DUF4271 PF14093.6 ORX50860.1 - 0.96 9.3 10.1 5 7.0 8.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) IMS PF00817.20 ORX50861.1 - 1e-44 152.1 0.0 1.8e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family BRCT_2 PF16589.5 ORX50861.1 - 4.3e-12 46.3 0.0 1.1e-11 45.0 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain IMS_C PF11799.8 ORX50861.1 - 3.5e-10 40.6 0.1 8.9e-10 39.3 0.1 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain REV1_C PF16727.5 ORX50861.1 - 5.6e-10 39.5 0.1 1.3e-09 38.3 0.1 1.7 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain BRCT PF00533.26 ORX50861.1 - 5e-07 30.0 0.0 1.3e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain UBM PF14377.6 ORX50861.1 - 6.6e-07 28.6 9.8 0.0034 16.8 0.2 3.7 3 0 0 3 3 3 2 Ubiquitin binding region LIG3_BRCT PF16759.5 ORX50861.1 - 1.3e-05 25.4 0.0 3.4e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ORX50861.1 - 0.0015 18.4 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain IMS_HHH PF11798.8 ORX50861.1 - 0.078 13.3 0.0 0.31 11.5 0.0 2.1 2 0 0 2 2 2 0 IMS family HHH motif mCpol PF18182.1 ORX50861.1 - 0.17 12.2 0.1 0.77 10.1 0.0 2.1 2 0 0 2 2 2 0 minimal CRISPR polymerase domain GDI PF00996.18 ORX50863.1 - 1.1e-215 716.2 0.1 1.2e-215 716.1 0.1 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor Amino_oxidase PF01593.24 ORX50863.1 - 0.0016 17.8 0.0 0.0022 17.4 0.0 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase zf-Nse PF11789.8 ORX50864.1 - 1.2e-17 63.5 0.1 2e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ORX50864.1 - 2.1e-06 27.6 0.2 4.2e-06 26.7 0.2 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX50864.1 - 0.0003 20.5 0.1 0.00068 19.4 0.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX50864.1 - 0.0035 17.5 0.2 0.0067 16.6 0.2 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-MIZ PF02891.20 ORX50864.1 - 0.0058 16.4 0.4 0.011 15.5 0.4 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-C3HC4 PF00097.25 ORX50864.1 - 0.022 14.6 1.1 0.034 14.0 0.1 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Vta1_C PF18097.1 ORX50864.1 - 3.9 7.3 0.0 3.9 7.3 0.0 3.5 5 0 0 5 5 5 0 Vta1 C-terminal domain Arrestin_C PF02752.22 ORX50865.1 - 1.7e-06 28.5 0.1 0.0017 18.8 0.0 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX50865.1 - 0.00047 20.2 0.8 0.23 11.5 0.0 3.1 3 0 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain FSH1 PF03959.13 ORX50868.1 - 4e-53 180.2 0.0 4.5e-53 180.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ORX50868.1 - 0.023 14.3 0.0 3 7.4 0.0 2.3 2 1 0 2 2 2 0 alpha/beta hydrolase fold sCache_3_3 PF17202.4 ORX50868.1 - 0.026 15.0 0.0 0.049 14.1 0.0 1.4 1 0 0 1 1 1 0 Single cache domain 3 Docking PF08990.11 ORX50868.1 - 0.082 12.5 0.1 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Erythronolide synthase docking DLH PF01738.18 ORX50868.1 - 0.17 11.4 0.1 1.3 8.5 0.1 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family tRNA_int_endo PF01974.17 ORX50869.1 - 1.1e-21 76.7 0.1 2.4e-21 75.6 0.1 1.5 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain DUF1688 PF07958.11 ORX50870.1 - 1.7e-149 498.1 0.0 1.9e-149 498.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) PsbI PF02532.14 ORX50870.1 - 0.14 12.1 0.2 0.3 11.1 0.2 1.5 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Isochorismatase PF00857.20 ORX50871.1 - 1.3e-30 106.9 0.1 2.3e-30 106.0 0.1 1.4 1 1 0 1 1 1 1 Isochorismatase family DUF1269 PF06897.12 ORX50871.1 - 0.13 12.6 0.1 0.63 10.3 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1269) CAF1 PF04857.20 ORX50872.1 - 3.5e-21 75.7 1.0 6.6e-11 41.9 0.0 2.6 1 1 0 2 2 2 2 CAF1 family ribonuclease Ldh_1_C PF02866.18 ORX50873.1 - 2.8e-48 164.0 0.2 4.6e-48 163.3 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ORX50873.1 - 1.3e-46 158.2 0.2 2e-46 157.6 0.2 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ORX50873.1 - 5.5e-05 22.3 0.0 0.0002 20.5 0.0 1.8 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 ORX50873.1 - 0.0011 19.0 0.2 0.0041 17.2 0.0 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus THF_DHG_CYH_C PF02882.19 ORX50873.1 - 0.0029 16.9 1.5 0.019 14.3 0.3 2.6 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Glyco_hydro_4 PF02056.16 ORX50873.1 - 0.056 13.0 1.3 7.5 6.1 0.0 3.0 2 1 1 3 3 3 0 Family 4 glycosyl hydrolase Glyco_transf_20 PF00982.21 ORX50874.1 - 2.1e-166 554.3 0.1 2.9e-166 553.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX50874.1 - 1.8e-51 174.5 0.0 2.7e-51 173.9 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ORX50874.1 - 8.8e-07 28.9 0.0 0.00048 19.9 0.1 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase PAP2_3 PF14378.6 ORX50875.1 - 4.7e-24 85.1 9.3 8e-24 84.4 9.3 1.4 1 0 0 1 1 1 1 PAP2 superfamily PAP2 PF01569.21 ORX50875.1 - 5.9e-10 39.0 4.0 5.9e-10 39.0 4.0 1.9 2 1 1 3 3 3 1 PAP2 superfamily NUDIX PF00293.28 ORX50876.1 - 2.6e-10 40.4 0.0 4.1e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Acetyltransf_1 PF00583.25 ORX50877.1 - 1.9e-17 63.6 0.0 2.3e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX50877.1 - 1e-11 45.1 0.0 1.4e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX50877.1 - 1.2e-11 44.6 0.1 1.7e-11 44.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX50877.1 - 7.7e-08 32.2 0.0 1.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ORX50877.1 - 3e-06 27.4 0.0 3.9e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ORX50877.1 - 0.00044 19.8 0.1 0.00049 19.6 0.1 1.1 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 ORX50877.1 - 0.0066 17.1 0.0 0.0081 16.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ORX50877.1 - 0.026 14.2 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_8 PF13523.6 ORX50877.1 - 0.043 13.5 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX50877.1 - 0.047 13.8 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Nudix_hydro PF18290.1 ORX50877.1 - 0.048 13.7 0.2 0.079 13.0 0.2 1.3 1 0 0 1 1 1 0 Nudix hydrolase domain Acetyltransf_18 PF18014.1 ORX50877.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Na_H_Exchanger PF00999.21 ORX50878.1 - 6e-64 216.2 28.7 7.8e-64 215.8 28.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family YrhC PF14143.6 ORX50878.1 - 0.46 10.6 4.8 0.23 11.5 0.8 2.7 2 0 0 2 2 2 0 YrhC-like protein XET_C PF06955.12 ORX50879.1 - 0.057 13.3 0.0 0.2 11.5 0.0 1.9 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus DUF2656 PF10847.8 ORX50879.1 - 0.064 13.4 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2656) eIF3_p135 PF12807.7 ORX50880.1 - 0.067 13.2 2.8 14 5.6 0.0 3.7 3 1 0 3 3 3 0 Translation initiation factor eIF3 subunit 135 F-box PF00646.33 ORX50881.1 - 4.7e-06 26.3 0.3 9.6e-05 22.2 0.0 2.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX50881.1 - 4.9e-06 26.3 0.4 1.8e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 F-box-like DUSP PF06337.12 ORX50881.1 - 0.086 13.5 0.0 0.26 11.9 0.0 1.8 1 0 0 1 1 1 0 DUSP domain C1_1 PF00130.22 ORX50881.1 - 0.21 11.5 4.1 0.32 10.9 1.5 2.4 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) LRV_FeS PF05484.11 ORX50881.1 - 0.28 11.2 5.9 6.5 6.9 0.2 3.2 2 1 1 3 3 3 0 LRV protein FeS4 cluster HypA PF01155.19 ORX50881.1 - 0.29 11.1 1.3 1.3 9.0 1.3 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RNA_POL_M_15KD PF02150.16 ORX50881.1 - 0.41 10.6 5.0 6 6.8 0.3 3.2 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit adh_short PF00106.25 ORX50882.1 - 4.3e-32 111.1 0.0 6.1e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX50882.1 - 1.2e-23 83.9 0.0 1.4e-23 83.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX50882.1 - 7.7e-07 29.2 0.0 1.1e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ORX50882.1 - 5.4e-06 26.4 0.0 5.8e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX50882.1 - 0.064 12.7 0.1 0.13 11.7 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_25 PF13649.6 ORX50883.1 - 2.2e-17 63.5 0.0 4.4e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX50883.1 - 2.4e-14 53.5 0.0 4.1e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX50883.1 - 2.9e-14 53.5 0.0 5.7e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX50883.1 - 4.1e-13 49.4 0.0 2.7e-12 46.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX50883.1 - 1.2e-09 38.8 0.0 2.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX50883.1 - 3e-08 33.3 0.0 5.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX50883.1 - 5.5e-07 29.9 0.0 1.5e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 ORX50883.1 - 5.6e-06 25.9 0.0 0.00013 21.5 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.15 ORX50883.1 - 6.3e-05 22.9 0.0 0.0001 22.2 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_2 PF00891.18 ORX50883.1 - 0.0011 18.3 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 ORX50883.1 - 0.0016 18.0 0.0 0.0047 16.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 ORX50883.1 - 0.0068 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 ORX50883.1 - 0.0088 15.4 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_29 PF03141.16 ORX50883.1 - 0.031 12.8 0.0 0.83 8.1 0.0 2.1 1 1 1 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_9 PF08003.11 ORX50883.1 - 0.055 12.4 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Itfg2 PF15907.5 ORX50884.1 - 1.6e-51 175.3 5.9 5.5e-22 78.2 0.0 6.2 4 2 2 6 6 6 6 Integrin-alpha FG-GAP repeat-containing protein 2 VCBS PF13517.6 ORX50884.1 - 1.8e-05 25.2 1.2 0.092 13.4 0.1 4.1 4 0 0 4 4 4 2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella BBS2_Mid PF14783.6 ORX50884.1 - 0.0097 15.9 0.9 4.5 7.4 0.0 3.2 4 0 0 4 4 4 2 Ciliary BBSome complex subunit 2, middle region FG-GAP PF01839.23 ORX50884.1 - 0.078 13.1 1.6 8.5 6.6 0.3 2.9 2 0 0 2 2 2 0 FG-GAP repeat TFA2_Winged_2 PF18121.1 ORX50886.1 - 2.1e-18 65.7 0.1 4.3e-18 64.8 0.1 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 ORX50886.1 - 2.3e-16 59.8 0.1 5.6e-16 58.6 0.1 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain HTH_47 PF16221.5 ORX50886.1 - 0.15 11.6 0.0 0.39 10.3 0.0 1.8 1 0 0 1 1 1 0 winged helix-turn-helix SMAP PF15477.6 ORX50887.1 - 1.6e-13 51.4 3.8 1.6e-13 51.4 3.8 2.5 2 1 0 2 2 2 1 Small acidic protein family MLANA PF14991.6 ORX50887.1 - 0.57 10.5 3.2 1.2 9.4 3.2 1.5 1 0 0 1 1 1 0 Protein melan-A DUF5427 PF10310.9 ORX50887.1 - 0.71 8.8 19.2 0.85 8.5 19.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Zip PF02535.22 ORX50887.1 - 0.99 8.6 9.2 1 8.5 9.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ORX50887.1 - 1.8 6.8 12.8 1.7 6.8 12.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Roughex PF06020.11 ORX50887.1 - 2.3 7.3 8.0 2.6 7.1 8.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF2151 PF10221.9 ORX50887.1 - 2.5 6.6 12.4 2.7 6.5 12.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Membralin PF09746.9 ORX50887.1 - 3.4 6.6 4.3 3.4 6.6 4.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein Connexin PF00029.19 ORX50887.1 - 5.5 6.7 12.2 8 6.1 12.2 1.3 1 0 0 1 1 1 0 Connexin Dynactin_p62 PF05502.13 ORX50887.1 - 9.2 4.9 11.9 12 4.5 11.9 1.1 1 0 0 1 1 1 0 Dynactin p62 family Mt_ATP-synt_B PF05405.14 ORX50888.1 - 7e-47 159.1 7.2 8.8e-47 158.8 7.2 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF5623 PF18536.1 ORX50888.1 - 0.058 13.7 1.0 0.15 12.4 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5623) DUF1539 PF07560.11 ORX50888.1 - 0.11 12.6 0.9 0.22 11.6 0.7 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) MPP6 PF10175.9 ORX50889.1 - 1.2e-20 74.4 18.0 1.8e-20 73.8 18.0 1.3 1 0 0 1 1 1 1 M-phase phosphoprotein 6 Utp14 PF04615.13 ORX50889.1 - 1e-05 24.4 18.1 1.2e-05 24.2 18.1 1.0 1 0 0 1 1 1 1 Utp14 protein Carb_kinase PF01256.17 ORX50890.1 - 7.1e-58 195.9 0.0 9e-58 195.6 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 ORX50890.1 - 6.3e-05 22.5 0.0 0.00013 21.5 0.0 1.5 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase HK PF02110.15 ORX50890.1 - 0.011 15.1 0.0 0.014 14.8 0.0 1.3 1 0 0 1 1 1 0 Hydroxyethylthiazole kinase family Band_7 PF01145.25 ORX50891.1 - 6e-29 101.3 1.1 7.9e-29 100.9 1.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ORX50891.1 - 0.002 17.9 0.1 0.0029 17.3 0.1 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family Band_7 PF01145.25 ORX50892.1 - 1.7e-27 96.6 0.1 2e-27 96.4 0.1 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ORX50892.1 - 0.0038 17.0 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 SPFH domain-Band 7 family 6PGD PF00393.19 ORX50893.1 - 3.8e-129 430.2 0.0 4.6e-129 429.9 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ORX50893.1 - 1.2e-44 152.3 0.0 1.7e-44 151.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ORX50893.1 - 0.023 14.9 0.1 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase Sugar_tr PF00083.24 ORX50894.1 - 5.5e-52 177.1 23.4 7.1e-52 176.8 23.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX50894.1 - 3.4e-26 92.0 24.8 3.4e-26 92.0 24.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5493 PF17597.2 ORX50894.1 - 1.9 8.8 9.6 8.8 6.7 2.3 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5493) Thioredoxin PF00085.20 ORX50896.1 - 8.5e-25 86.7 0.2 7e-22 77.4 0.0 4.0 4 1 1 5 5 5 1 Thioredoxin Thioredoxin_6 PF13848.6 ORX50896.1 - 1.5e-13 51.1 0.0 3.5e-09 36.8 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ORX50896.1 - 0.01 16.3 0.4 1.4 9.4 0.2 3.1 2 1 0 2 2 2 0 Thioredoxin-like domain Thioredoxin_9 PF14595.6 ORX50896.1 - 0.036 13.8 0.0 5 6.9 0.0 2.5 2 0 0 2 2 2 0 Thioredoxin GPP34 PF05719.11 ORX50897.1 - 1.1e-32 113.8 0.0 1.4e-32 113.4 0.0 1.0 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) SieB PF14163.6 ORX50897.1 - 0.087 12.3 0.1 0.19 11.2 0.1 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B BAG PF02179.16 ORX50898.1 - 0.0022 18.4 0.1 0.11 13.0 0.0 2.6 2 1 0 2 2 2 1 BAG domain DUF5588 PF17826.1 ORX50898.1 - 0.088 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5588) SpoIIE PF07228.12 ORX50899.1 - 8.4e-15 55.2 0.0 1.2e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ORX50899.1 - 2.3e-07 30.7 0.0 3.9e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 ORX50899.1 - 0.00025 20.8 0.1 0.26 10.9 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C TFIIB PF00382.19 ORX50899.1 - 0.17 12.0 0.1 0.32 11.1 0.1 1.4 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Ribosomal_L27e PF01777.18 ORX50900.1 - 1.2e-37 128.1 7.0 1.2e-37 128.1 7.0 1.5 2 0 0 2 2 2 1 Ribosomal L27e protein family KOW PF00467.29 ORX50900.1 - 0.00069 19.5 4.0 0.0017 18.2 4.0 1.9 1 1 0 1 1 1 1 KOW motif Prok-RING_4 PF14447.6 ORX50905.1 - 0.012 15.5 2.5 6.4 6.7 0.1 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 UIM PF02809.20 ORX50905.1 - 0.014 15.3 4.4 0.014 15.3 4.4 2.1 2 0 0 2 2 2 0 Ubiquitin interaction motif Rad50_zn_hook PF04423.14 ORX50905.1 - 0.022 14.6 0.2 3.5 7.6 0.0 2.6 2 0 0 2 2 2 0 Rad50 zinc hook motif RNF220 PF15926.5 ORX50905.1 - 0.097 12.3 7.2 0.32 10.6 0.3 2.9 2 1 1 3 3 3 0 E3 ubiquitin-protein ligase RNF220 DUF2225 PF09986.9 ORX50905.1 - 0.11 12.2 0.8 12 5.5 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_2 PF13465.6 ORX50905.1 - 0.6 10.6 3.0 9.1 6.9 0.1 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-TFIIB PF13453.6 ORX50905.1 - 1.4 8.3 4.5 7 6.1 0.3 2.5 2 0 0 2 2 2 0 Transcription factor zinc-finger Zn-ribbon_8 PF09723.10 ORX50905.1 - 1.8 8.7 6.3 16 5.7 0.3 3.1 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_12 PF18658.1 ORX50905.1 - 2.6 7.7 9.9 0.93 9.1 0.9 3.1 3 0 0 3 3 3 0 Zinc-finger C2H2-type zf-Di19 PF05605.12 ORX50905.1 - 3.5 8.0 10.4 9.5 6.6 1.3 3.3 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-CHY PF05495.12 ORX50905.1 - 5.4 7.6 7.5 18 5.9 0.2 3.0 3 0 0 3 3 3 0 CHY zinc finger RNB PF00773.19 ORX50906.1 - 5.3e-103 344.8 0.0 7.9e-103 344.2 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX50906.1 - 7e-19 67.6 0.0 2.3e-18 66.0 0.0 2.0 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ORX50906.1 - 1e-10 41.8 0.0 5e-10 39.6 0.0 2.1 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal Rrp44_CSD1 PF17216.3 ORX50906.1 - 6.1e-06 26.0 0.1 1.2e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 Rrp44-like cold shock domain CSD2 PF17876.1 ORX50906.1 - 6.8e-05 23.0 0.0 0.0027 17.8 0.0 3.2 3 0 0 3 3 3 1 Cold shock domain Redoxin PF08534.10 ORX50906.1 - 0.047 13.4 0.2 5.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Redoxin XLF PF09302.11 ORX50906.1 - 0.048 13.8 0.4 0.11 12.7 0.4 1.5 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component RITA PF17066.5 ORX50906.1 - 0.052 13.1 0.4 0.088 12.4 0.4 1.2 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein Co_AT_N PF12557.8 ORX50906.1 - 0.14 12.2 2.4 0.45 10.5 2.4 1.9 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal adh_short PF00106.25 ORX50907.1 - 3e-79 265.0 9.0 4.8e-42 143.6 0.5 2.6 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ORX50907.1 - 4.7e-63 212.9 9.7 9.5e-34 117.0 0.8 2.5 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 ORX50907.1 - 8.8e-32 109.3 0.0 1.8e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 ORX50907.1 - 9.8e-30 103.8 6.8 3.2e-15 56.5 1.3 2.2 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 ORX50907.1 - 0.0003 20.9 0.0 0.004 17.3 0.0 2.7 3 0 0 3 3 3 1 N-terminal half of MaoC dehydratase THF_DHG_CYH_C PF02882.19 ORX50907.1 - 0.00056 19.3 1.0 0.068 12.5 0.6 2.6 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Epimerase PF01370.21 ORX50907.1 - 0.0021 17.6 2.3 0.24 10.8 0.1 2.5 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family PglL_A PF15864.5 ORX50907.1 - 1.1 9.0 6.4 10 6.0 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase 3HCDH_N PF02737.18 ORX50907.1 - 3.8 7.3 7.3 15 5.4 0.6 2.4 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HAD_2 PF13419.6 ORX50908.1 - 1.1e-21 77.7 0.0 1.6e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX50908.1 - 1.6e-13 51.5 0.1 1.1e-12 48.8 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX50908.1 - 3.1e-06 27.1 0.1 7.1e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ORX50908.1 - 2.7e-05 24.7 0.0 3.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PET PF06297.14 ORX50908.1 - 0.0044 17.3 0.0 0.0082 16.4 0.0 1.4 1 0 0 1 1 1 1 PET Domain Mito_carr PF00153.27 ORX50909.1 - 3.5e-63 209.6 0.7 3.3e-21 75.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX50909.1 - 0.00034 19.9 0.1 0.25 10.5 0.0 2.7 3 0 0 3 3 3 2 Gammaproteobacterial serine protease IucA_IucC PF04183.12 ORX50910.1 - 1.3e-23 83.9 0.1 2.1e-23 83.2 0.1 1.4 1 0 0 1 1 1 1 IucA / IucC family FhuF PF06276.12 ORX50910.1 - 1.2e-14 55.1 0.1 2.4e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 Ferric iron reductase FhuF-like transporter Sulfate_transp PF00916.20 ORX50911.1 - 2.1e-89 299.9 14.7 2.9e-69 233.7 5.7 2.3 1 1 1 2 2 2 2 Sulfate permease family STAS PF01740.21 ORX50911.1 - 6.5e-08 32.2 0.0 1.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX50911.1 - 0.00015 22.1 5.4 0.00015 22.1 5.4 2.6 2 1 1 3 3 3 1 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ORX50911.1 - 0.011 16.1 0.0 0.025 14.9 0.0 1.6 1 0 0 1 1 1 0 STAS domain LRR_6 PF13516.6 ORX50912.1 - 5.7e-05 22.9 16.0 0.041 14.0 0.1 6.3 6 0 0 6 6 6 3 Leucine Rich repeat PH PF00169.29 ORX50912.1 - 0.0014 19.1 0.0 0.0079 16.7 0.0 2.3 2 0 0 2 2 2 1 PH domain Ras PF00071.22 ORX50913.1 - 1e-55 187.8 0.1 1.2e-55 187.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX50913.1 - 1.8e-20 73.3 0.0 3.5e-20 72.4 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX50913.1 - 5.8e-08 32.4 0.0 7.3e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX50913.1 - 3.4e-05 23.5 0.2 0.00037 20.1 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX50913.1 - 0.0011 19.0 0.0 0.34 10.8 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX50913.1 - 0.0027 17.3 0.2 0.021 14.3 0.2 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ORX50913.1 - 0.005 16.9 0.0 0.0086 16.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.6 ORX50913.1 - 0.081 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX50913.1 - 0.088 13.2 0.2 42 4.6 0.0 3.0 2 1 1 3 3 3 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 ORX50913.1 - 0.13 12.3 0.1 0.32 11.0 0.0 1.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Cyclin_N PF00134.23 ORX50914.1 - 8.1e-15 54.7 0.1 3.3e-11 43.0 0.0 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ORX50914.1 - 4.8e-05 23.4 0.4 0.00012 22.1 0.1 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain TFIIB PF00382.19 ORX50914.1 - 0.0019 18.2 0.4 3 8.0 0.4 3.0 2 2 0 2 2 2 2 Transcription factor TFIIB repeat Spy1 PF11357.8 ORX50914.1 - 0.042 14.1 0.7 0.77 10.1 0.0 2.7 2 1 0 2 2 2 0 Cell cycle regulatory protein Aldedh PF00171.22 ORX50915.1 - 4.8e-140 467.1 0.8 5.5e-140 466.9 0.8 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LZ3wCH PF18517.1 ORX50915.1 - 0.097 12.8 0.3 0.2 11.8 0.3 1.6 1 0 0 1 1 1 0 Leucine zipper with capping helix domain BCAS3 PF12490.8 ORX50916.1 - 2.3e-05 24.0 2.7 0.00071 19.2 1.4 2.7 2 1 0 2 2 2 1 Breast carcinoma amplified sequence 3 GHMP_kinases_N PF00288.26 ORX50917.1 - 3.8e-05 23.9 0.0 8.9e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain NTP_transf_3 PF12804.7 ORX50917.1 - 0.00015 22.2 0.1 0.00087 19.7 0.0 2.3 3 0 0 3 3 3 1 MobA-like NTP transferase domain GHMP_kinases_C PF08544.13 ORX50917.1 - 0.0031 17.8 0.0 0.0069 16.7 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal OrfB_Zn_ribbon PF07282.11 ORX50919.1 - 6.5e-05 22.8 0.8 0.00021 21.2 0.8 1.9 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DUF1368 PF07112.11 ORX50919.1 - 0.025 13.4 1.5 0.034 13.0 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1368) zf-C2H2_10 PF16588.5 ORX50921.1 - 8.7e-08 31.7 13.9 5.6e-06 26.0 3.8 2.8 3 0 0 3 3 3 2 C2H2 zinc-finger zf-CCHC PF00098.23 ORX50921.1 - 8.3e-06 25.6 9.2 0.00011 22.1 0.3 2.3 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_4 PF14392.6 ORX50921.1 - 0.00012 21.8 4.9 0.057 13.2 0.8 2.3 2 0 0 2 2 2 2 Zinc knuckle Exo_endo_phos PF03372.23 ORX50922.1 - 6.9e-05 22.5 0.1 0.00011 21.8 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX50922.1 - 0.001 18.9 0.6 0.0039 17.0 0.1 2.3 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Stress-antifung PF01657.17 ORX50922.1 - 0.08 13.6 0.2 15 6.3 0.2 2.6 2 0 0 2 2 2 0 Salt stress response/antifungal Exonuc_VII_L PF02601.15 ORX50922.1 - 0.3 10.6 1.2 0.52 9.8 1.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RVT PF13966.6 ORX50923.1 - 5.6e-10 39.8 0.3 9.3e-10 39.1 0.3 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase SURF4 PF02077.15 ORX50924.1 - 5.7e-95 317.9 8.0 6.4e-95 317.8 8.0 1.0 1 0 0 1 1 1 1 SURF4 family AAA_2 PF07724.14 ORX50925.1 - 1.3e-55 188.1 0.7 1.5e-53 181.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ORX50925.1 - 1.3e-36 124.6 4.3 6.7e-36 122.4 1.6 2.7 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 ORX50925.1 - 4.1e-26 90.8 0.0 1.4e-25 89.2 0.0 2.0 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 ORX50925.1 - 1.2e-22 80.7 0.1 1.8e-11 44.6 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX50925.1 - 3.7e-17 62.6 0.2 1.9e-11 44.1 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX50925.1 - 3.8e-11 43.0 0.1 8.7e-07 28.8 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 ORX50925.1 - 7.7e-10 39.4 1.3 3.9e-05 24.1 0.1 4.2 2 2 0 3 3 3 2 AAA ATPase domain Mg_chelatase PF01078.21 ORX50925.1 - 6.5e-07 28.9 0.1 0.062 12.7 0.0 3.4 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI TniB PF05621.11 ORX50925.1 - 8.2e-07 28.6 0.0 0.0039 16.6 0.0 3.6 2 1 0 2 2 2 1 Bacterial TniB protein AAA_22 PF13401.6 ORX50925.1 - 1.9e-06 28.2 3.2 0.026 14.8 0.0 4.2 2 2 1 3 3 3 2 AAA domain AAA_7 PF12775.7 ORX50925.1 - 4.4e-06 26.3 0.0 0.039 13.4 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 ORX50925.1 - 7.4e-06 26.0 0.0 0.031 14.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 ORX50925.1 - 8.7e-06 25.6 0.0 0.0059 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ORX50925.1 - 1.1e-05 25.3 0.0 0.016 14.9 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase_2 PF01637.18 ORX50925.1 - 3.2e-05 23.9 0.5 0.2 11.5 0.3 4.0 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ORX50925.1 - 0.00026 21.4 0.1 1.9 8.9 0.0 3.3 3 0 0 3 3 3 2 RNA helicase AAA_18 PF13238.6 ORX50925.1 - 0.00038 21.0 0.2 2.8 8.5 0.0 3.7 3 0 0 3 3 3 1 AAA domain Roc PF08477.13 ORX50925.1 - 0.00061 20.0 0.0 1.9 8.7 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ORX50925.1 - 0.0007 20.1 0.4 0.13 12.7 0.0 3.3 3 0 0 3 3 3 1 ABC transporter TsaE PF02367.17 ORX50925.1 - 0.00098 19.1 0.0 0.59 10.1 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ORX50925.1 - 0.0024 17.8 0.3 0.24 11.3 0.0 2.9 2 1 0 2 2 2 1 NACHT domain RsgA_GTPase PF03193.16 ORX50925.1 - 0.0063 16.4 0.0 2.9 7.8 0.0 2.8 2 0 0 2 2 2 1 RsgA GTPase DNA_pol3_delta2 PF13177.6 ORX50925.1 - 0.0074 16.1 0.0 16 5.2 0.0 3.5 3 0 0 3 3 3 0 DNA polymerase III, delta subunit AAA_19 PF13245.6 ORX50925.1 - 0.0083 16.5 0.6 5 7.4 0.1 3.1 3 1 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 ORX50925.1 - 0.0089 15.3 0.0 0.28 10.4 0.0 2.7 2 0 0 2 2 2 1 Zeta toxin PduV-EutP PF10662.9 ORX50925.1 - 0.012 15.4 0.0 1 9.1 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 ORX50925.1 - 0.012 15.9 0.1 8.5 6.6 0.0 3.4 3 0 0 3 3 2 0 AAA domain AAA_30 PF13604.6 ORX50925.1 - 0.013 15.2 2.0 1.2 8.9 0.6 3.2 2 2 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX50925.1 - 0.022 14.9 0.1 5.2 7.2 0.0 3.0 2 1 0 2 2 2 0 AAA domain Torsin PF06309.11 ORX50925.1 - 0.036 14.2 0.0 0.19 11.8 0.0 2.0 2 0 0 2 2 2 0 Torsin SRP54 PF00448.22 ORX50925.1 - 0.043 13.4 0.0 4.9 6.7 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ResIII PF04851.15 ORX50925.1 - 0.06 13.4 0.1 13 5.7 0.0 3.2 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX50925.1 - 0.085 12.3 0.0 3.4 7.1 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.11 ORX50925.1 - 0.14 12.0 0.1 6.4 6.6 0.0 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 ORX50925.1 - 0.14 12.2 0.1 11 6.1 0.0 3.0 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Prefoldin PF02996.17 ORX50925.1 - 0.2 11.6 7.9 0.21 11.5 0.5 3.7 3 1 1 4 4 4 0 Prefoldin subunit DUF4407 PF14362.6 ORX50925.1 - 0.34 10.2 2.7 0.63 9.3 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TIP49 PF06068.13 ORX50925.1 - 0.64 9.2 8.9 4.7 6.3 0.0 3.7 4 0 0 4 4 4 0 TIP49 P-loop domain DUF4349 PF14257.6 ORX50925.1 - 2.2 7.7 10.1 0.84 9.0 2.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) AAA_15 PF13175.6 ORX50925.1 - 8.1 6.0 7.4 7.6 6.1 1.9 2.5 3 0 0 3 3 3 0 AAA ATPase domain MFS_1 PF07690.16 ORX50926.1 - 1.6e-43 149.0 43.4 2.3e-41 141.9 35.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Proteasom_Rpn13 PF04683.13 ORX50927.1 - 4.6e-30 104.0 0.3 8.4e-30 103.2 0.3 1.4 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 ORX50927.1 - 2.1e-11 44.0 2.1 3.3e-11 43.3 1.2 1.7 2 0 0 2 2 2 1 UCH-binding domain Nif11 PF07862.11 ORX50927.1 - 0.05 13.9 1.0 3.1 8.2 0.0 3.2 3 0 0 3 3 3 0 Nif11 domain ECH_2 PF16113.5 ORX50927.1 - 0.081 12.4 0.2 0.12 11.9 0.2 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase PolyA_pol_RNAbd PF12627.7 ORX50927.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A ImpE PF07024.13 ORX50928.1 - 0.1 12.7 0.0 0.17 12.0 0.0 1.3 1 1 0 1 1 1 0 ImpE protein dCMP_cyt_deam_1 PF00383.23 ORX50931.1 - 9e-25 86.5 0.2 1.2e-24 86.1 0.2 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX50931.1 - 6.7e-22 77.7 0.0 8.7e-22 77.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ORX50931.1 - 3.3e-05 24.0 0.0 5.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 ORX50931.1 - 7.7e-05 22.8 0.0 0.00012 22.2 0.0 1.3 1 0 0 1 1 1 1 APOBEC3 APOBEC1 PF18769.1 ORX50931.1 - 0.0012 19.1 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 APOBEC1 NAD1 PF18778.1 ORX50931.1 - 0.0012 19.0 0.0 0.0016 18.6 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 APOBEC2 PF18772.1 ORX50931.1 - 0.0019 18.3 0.0 0.0025 17.9 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 APOBEC4_like PF18774.1 ORX50931.1 - 0.0021 18.0 0.0 0.0035 17.3 0.0 1.3 1 0 0 1 1 1 1 APOBEC4-like -AID/APOBEC-deaminase Bd3614-deam PF14439.6 ORX50931.1 - 0.018 15.1 0.7 0.18 11.9 0.7 2.1 1 1 0 1 1 1 0 Bd3614-like deaminase APOBEC_N PF08210.11 ORX50931.1 - 0.022 14.6 0.1 0.031 14.2 0.1 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain NAD2 PF18782.1 ORX50931.1 - 0.083 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 PP2C PF00481.21 ORX50932.1 - 2.7e-80 269.7 0.0 3.8e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PCNA_C PF02747.15 ORX50932.1 - 0.019 15.2 0.1 0.037 14.2 0.1 1.4 1 0 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain Kinesin PF00225.23 ORX50933.1 - 6e-113 377.1 0.4 1.4e-112 376.0 0.2 1.8 2 0 0 2 2 2 1 Kinesin motor domain Kinesin_assoc PF16183.5 ORX50933.1 - 3.8e-52 177.1 1.5 1.7e-51 174.9 1.5 2.3 1 0 0 1 1 1 1 Kinesin-associated DUF3694 PF12473.8 ORX50933.1 - 7.9e-38 130.5 0.4 7.9e-38 130.5 0.4 2.4 2 1 0 2 2 2 1 Kinesin protein Microtub_bd PF16796.5 ORX50933.1 - 1.7e-28 99.5 0.0 4.5e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 ORX50933.1 - 8.3e-13 48.8 0.2 2.4e-12 47.3 0.2 1.8 1 0 0 1 1 1 1 PH domain FHA PF00498.26 ORX50933.1 - 4.2e-09 36.6 0.1 2e-08 34.5 0.1 2.3 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 ORX50933.1 - 3.6e-06 27.3 0.1 1.3e-05 25.6 0.1 2.1 1 0 0 1 1 1 1 Kinesin protein 1B Yop-YscD_cpl PF16697.5 ORX50933.1 - 3.2e-05 24.1 0.0 0.00012 22.3 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain LigD_N PF13298.6 ORX50933.1 - 0.0014 18.9 0.3 0.036 14.4 0.3 2.9 2 0 0 2 2 2 1 DNA polymerase Ligase (LigD) PH_9 PF15410.6 ORX50933.1 - 0.022 15.1 0.2 0.091 13.1 0.1 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain DUF2515 PF10720.9 ORX50933.1 - 0.022 14.0 0.1 7.9 5.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2515) Metallophos PF00149.28 ORX50934.1 - 8.5e-36 124.4 0.1 1.4e-35 123.7 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF1647 PF07801.11 ORX50934.1 - 0.2 11.4 1.0 0.89 9.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1647) Thioredoxin PF00085.20 ORX50935.1 - 2.1e-34 117.6 0.0 4.2e-29 100.6 0.1 2.9 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_8 PF13905.6 ORX50935.1 - 3.6e-08 33.6 0.0 0.00018 21.7 0.0 3.8 3 1 1 4 4 4 3 Thioredoxin-like Thioredoxin_2 PF13098.6 ORX50935.1 - 2.4e-07 31.2 0.1 0.00098 19.5 0.1 2.7 3 0 0 3 3 3 2 Thioredoxin-like domain OST3_OST6 PF04756.13 ORX50935.1 - 4.2e-06 26.3 0.0 0.0039 16.6 0.0 2.2 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 ORX50935.1 - 0.0039 17.1 0.3 0.017 15.0 0.0 2.1 2 0 0 2 2 2 1 AhpC/TSA family HyaE PF07449.11 ORX50935.1 - 0.0048 16.8 0.0 13 5.8 0.0 3.6 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE Thioredoxin_3 PF13192.6 ORX50935.1 - 0.0058 16.7 0.1 0.91 9.6 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain TraF PF13728.6 ORX50935.1 - 0.051 13.4 2.2 6.7 6.5 0.0 3.3 4 0 0 4 4 4 0 F plasmid transfer operon protein Redoxin PF08534.10 ORX50935.1 - 0.057 13.1 0.1 0.15 11.7 0.1 1.7 1 0 0 1 1 1 0 Redoxin LIM PF00412.22 ORX50936.1 - 6.3e-36 122.4 40.3 5.6e-14 52.1 5.1 3.5 4 0 0 4 4 4 3 LIM domain Nucleopor_Nup85 PF07575.13 ORX50937.1 - 1.6e-38 132.7 0.1 8.5e-38 130.3 0.1 1.8 1 1 0 1 1 1 1 Nup85 Nucleoporin Ribosomal_L2_C PF03947.18 ORX50938.1 - 3.8e-54 182.2 1.5 3.8e-54 182.2 1.5 1.7 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ORX50938.1 - 3.2e-24 84.7 0.1 6.1e-24 83.8 0.1 1.5 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Gly_transf_sug PF04488.15 ORX50939.1 - 3.4e-06 27.6 0.1 7.1e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ORX50939.1 - 0.032 13.6 0.4 0.072 12.5 0.4 1.5 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 ORX50939.1 - 0.16 11.2 0.4 0.25 10.6 0.4 1.2 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Asp5 PF17000.5 ORX50939.1 - 0.19 11.9 0.4 4.9 7.4 0.1 2.3 2 0 0 2 2 2 0 Accessory secretory protein Sec, Asp5 CDC45 PF02724.14 ORX50940.1 - 0.22 9.7 0.9 0.28 9.4 0.9 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 ORX50940.1 - 1.6 9.2 12.0 13 6.3 11.2 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ORX50940.1 - 3.9 5.4 9.0 5.7 4.9 9.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Hydrolase_4 PF12146.8 ORX50941.1 - 3.9e-14 52.5 0.1 2e-10 40.4 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX50941.1 - 6e-10 39.2 0.2 1.9e-07 31.0 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX50941.1 - 4.3e-08 32.9 0.0 6.5e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF818 PF05677.12 ORX50941.1 - 4.3e-06 25.9 0.1 1.2e-05 24.5 0.1 1.6 2 0 0 2 2 2 1 Chlamydia CHLPS protein (DUF818) AXE1 PF05448.12 ORX50941.1 - 5.5e-06 25.3 0.1 0.47 9.1 0.0 3.0 2 1 1 3 3 3 3 Acetyl xylan esterase (AXE1) Peptidase_S15 PF02129.18 ORX50941.1 - 0.00093 18.9 0.0 0.15 11.6 0.0 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 ORX50941.1 - 0.0013 19.3 0.0 0.0017 19.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 ORX50941.1 - 0.0015 18.2 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Pkinase PF00069.25 ORX50943.1 - 1.9e-66 224.2 0.0 2.3e-66 223.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX50943.1 - 1.2e-29 103.4 0.0 2.8e-29 102.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX50943.1 - 0.00044 19.7 0.2 0.001 18.5 0.2 1.6 1 1 0 1 1 1 1 Kinase-like Imm7 PF15585.6 ORX50943.1 - 0.013 15.8 0.1 0.063 13.6 0.0 2.0 2 0 0 2 2 2 0 Immunity protein 7 Lysine_decarbox PF03641.14 ORX50944.1 - 2.6e-34 118.2 1.3 8.2e-19 68.0 0.1 2.1 2 0 0 2 2 2 2 Possible lysine decarboxylase LDcluster4 PF18306.1 ORX50944.1 - 2.7e-14 53.0 0.2 8.3e-13 48.2 0.4 2.1 1 1 1 2 2 2 2 SLOG cluster4 family PIG-S PF10510.9 ORX50945.1 - 2.3e-138 462.2 10.1 2.7e-138 462.0 10.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein ABC_membrane PF00664.23 ORX50946.1 - 1.6e-109 365.8 31.2 5.2e-60 203.4 15.4 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX50946.1 - 1.9e-70 235.7 0.0 2.4e-34 118.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX50946.1 - 1.5e-15 57.3 0.1 2.3e-08 33.8 0.0 4.0 3 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ORX50946.1 - 1.1e-09 37.6 0.1 0.00011 21.2 0.0 2.4 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 ORX50946.1 - 1.1e-06 29.0 1.8 0.054 13.8 0.2 3.9 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ORX50946.1 - 5.3e-06 26.9 6.3 0.011 16.1 0.2 3.9 3 2 0 3 3 2 2 AAA ATPase domain AAA_30 PF13604.6 ORX50946.1 - 1.5e-05 24.8 0.2 0.4 10.4 0.0 3.4 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX50946.1 - 3e-05 23.7 0.5 0.2 11.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX50946.1 - 5.6e-05 23.1 0.0 0.21 11.5 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 ORX50946.1 - 9.4e-05 21.7 0.0 0.041 13.0 0.0 2.4 2 0 0 2 2 2 2 G-protein alpha subunit Zeta_toxin PF06414.12 ORX50946.1 - 0.00021 20.6 0.1 0.85 8.9 0.0 3.1 3 0 0 3 3 3 2 Zeta toxin DUF87 PF01935.17 ORX50946.1 - 0.0003 21.0 0.2 0.73 9.9 0.0 2.8 3 0 0 3 3 3 2 Helicase HerA, central domain AAA_21 PF13304.6 ORX50946.1 - 0.00037 20.4 0.6 1.7 8.4 0.0 4.0 3 1 1 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_33 PF13671.6 ORX50946.1 - 0.00068 19.8 2.2 0.069 13.3 0.0 3.5 4 1 0 4 4 3 1 AAA domain SbcCD_C PF13558.6 ORX50946.1 - 0.00083 19.5 3.9 0.59 10.4 0.8 4.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 ORX50946.1 - 0.0031 17.6 0.0 2 8.5 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ORX50946.1 - 0.0045 17.5 0.0 1.7 9.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX50946.1 - 0.0048 16.4 0.0 4.4 6.8 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region NB-ARC PF00931.22 ORX50946.1 - 0.0057 15.9 0.2 1.8 7.7 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain SRP54 PF00448.22 ORX50946.1 - 0.0078 15.9 0.4 2.9 7.5 0.0 2.4 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Dala_Dala_lig_N PF01820.21 ORX50946.1 - 0.016 15.7 0.0 0.95 10.0 0.0 2.5 2 0 0 2 2 2 0 D-ala D-ala ligase N-terminus AAA_5 PF07728.14 ORX50946.1 - 0.019 14.9 0.0 13 5.8 0.0 2.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ORX50946.1 - 0.019 14.5 0.1 3.9 7.0 0.0 3.4 4 0 0 4 4 4 0 AAA domain AAA_15 PF13175.6 ORX50946.1 - 0.052 13.3 0.0 3.7 7.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ORX50946.1 - 0.085 13.3 0.0 24 5.4 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Rad17 PF03215.15 ORX50946.1 - 0.09 12.7 0.1 11 5.9 0.1 3.2 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_23 PF13476.6 ORX50946.1 - 0.092 13.2 0.3 4.1 7.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX50946.1 - 0.1 12.3 0.0 12 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain Synapsin_N PF10581.9 ORX50946.1 - 0.1 12.5 0.0 0.92 9.5 0.1 2.3 2 0 0 2 2 2 0 Synapsin N-terminal PufQ PF05398.11 ORX50946.1 - 0.72 10.0 2.9 6.3 7.0 1.6 2.7 2 0 0 2 2 2 0 PufQ cytochrome subunit Cg6151-P PF10233.9 ORX50947.1 - 2e-17 63.5 7.8 2.3e-17 63.3 7.8 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF5562 PF17717.1 ORX50947.1 - 0.13 12.3 0.8 0.14 12.1 0.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5562) DUF3040 PF11239.8 ORX50947.1 - 0.86 9.9 3.9 1 9.7 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2207 PF09972.9 ORX50947.1 - 6.1 5.5 6.0 7.2 5.2 6.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 ORX50948.1 - 5e-21 74.9 2.3 5e-21 74.9 2.3 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF202) MscS_TM PF12794.7 ORX50948.1 - 0.031 13.1 2.8 0.042 12.7 2.8 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 6PF2K PF01591.18 ORX50949.1 - 3.9e-67 225.8 0.0 5.1e-67 225.4 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX50949.1 - 2.5e-12 46.9 0.1 5e-12 45.9 0.1 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ORX50949.1 - 0.015 15.5 0.0 0.048 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain CYSTM PF12734.7 ORX50950.1 - 8.1e-05 22.9 23.4 0.00039 20.7 23.4 2.2 1 1 0 1 1 1 1 Cysteine-rich TM module stress tolerance ANXA2R PF15721.5 ORX50950.1 - 0.087 13.3 2.6 0.093 13.3 2.6 1.0 1 0 0 1 1 1 0 Annexin-2 receptor MFS_1 PF07690.16 ORX50951.1 - 7.9e-25 87.5 28.6 1.1e-24 87.0 28.6 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Plasmodium_Vir PF05795.11 ORX50952.1 - 0.79 9.1 3.6 0.9 8.9 3.6 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PDE8 PF08629.10 ORX50952.1 - 7.7 6.6 10.5 11 6.0 0.9 2.4 2 0 0 2 2 2 0 PDE8 phosphodiesterase MRP-S28 PF10213.9 ORX50953.1 - 1.1e-37 129.2 0.3 1.1e-37 129.2 0.3 1.5 2 0 0 2 2 2 1 Mitochondrial ribosomal subunit protein Vmethyltransf PF01660.17 ORX50953.1 - 0.06 12.2 0.0 0.067 12.0 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase ADH_zinc_N PF00107.26 ORX50954.1 - 2.4e-22 79.3 1.1 3.9e-22 78.6 1.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX50954.1 - 3.6e-12 47.5 0.1 9.9e-12 46.1 0.0 1.7 1 1 1 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX50954.1 - 0.0073 15.6 1.7 0.0098 15.2 0.9 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.25 ORX50954.1 - 0.031 13.7 0.2 0.067 12.6 0.2 1.5 1 0 0 1 1 1 0 short chain dehydrogenase ACP_syn_III_C PF08541.10 ORX50954.1 - 0.057 13.6 0.7 0.13 12.4 0.3 1.9 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal MMM1 PF10296.9 ORX50955.1 - 1.7e-05 24.0 0.0 0.00063 18.9 0.0 2.5 3 0 0 3 3 3 2 Maintenance of mitochondrial morphology protein 1 Aa_trans PF01490.18 ORX50956.1 - 1.7e-77 260.9 30.2 2.1e-77 260.6 30.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX50956.1 - 0.0005 19.2 11.1 0.0005 19.2 11.1 2.3 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family PAPS_reduct PF01507.19 ORX50958.1 - 3.4e-38 131.4 0.0 4.4e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family HEAT PF02985.22 ORX50959.1 - 3.1e-14 51.9 11.6 0.045 14.0 0.0 9.0 10 0 0 10 10 10 5 HEAT repeat HEAT_2 PF13646.6 ORX50959.1 - 5.4e-07 29.9 10.5 0.05 14.0 0.1 6.5 5 2 1 6 6 6 3 HEAT repeats Cnd1 PF12717.7 ORX50959.1 - 0.0071 16.4 1.0 15 5.6 0.0 4.6 5 1 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 ORX50959.1 - 0.025 14.3 0.0 0.075 12.7 0.0 1.8 1 0 0 1 1 1 0 NUC173 domain Vac14_Fab1_bd PF12755.7 ORX50959.1 - 0.027 15.1 4.2 7.3 7.3 0.0 4.2 5 0 0 5 5 5 0 Vacuolar 14 Fab1-binding region VID27_N PF17748.1 ORX50959.1 - 2.9 7.7 6.7 0.46 10.3 0.1 2.8 3 0 0 3 3 3 0 VID27 N-terminal region Smg8_Smg9 PF10220.9 ORX50960.1 - 1e-85 288.9 13.9 1.2e-38 133.1 4.7 4.2 4 0 0 4 4 4 4 Smg8_Smg9 Lactamase_B_2 PF12706.7 ORX50961.1 - 7.9e-26 90.8 0.1 1.1e-25 90.4 0.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX50961.1 - 2.8e-05 24.2 0.2 6e-05 23.1 0.2 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 ORX50961.1 - 0.0025 17.3 0.0 0.0073 15.8 0.0 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain PQ-loop PF04193.14 ORX50962.1 - 2.5e-13 49.6 1.1 2.5e-13 49.6 1.1 2.0 2 1 0 2 2 2 1 PQ loop repeat SUR7 PF06687.12 ORX50962.1 - 0.054 13.1 0.9 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 SUR7/PalI family DUF4231 PF14015.6 ORX50962.1 - 4.7 7.7 5.4 4.5 7.8 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF2530 PF10745.9 ORX50962.1 - 6.5 7.1 12.1 2.3 8.5 2.2 2.7 2 2 0 2 2 2 0 Protein of unknown function (DUF2530) ACBP PF00887.19 ORX50963.1 - 6.5e-23 80.7 0.3 7.1e-23 80.6 0.3 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 ORX50963.1 - 0.069 13.5 0.2 0.73 10.2 0.0 1.9 1 1 0 2 2 2 0 FERM central domain PDT PF00800.18 ORX50964.1 - 1.2e-59 201.2 0.0 1.6e-59 200.8 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase CM_2 PF01817.21 ORX50964.1 - 1.8e-20 73.1 0.5 3.3e-20 72.2 0.5 1.5 1 0 0 1 1 1 1 Chorismate mutase type II ACT PF01842.25 ORX50964.1 - 5.7e-08 32.4 0.0 2.2e-07 30.5 0.0 2.1 2 0 0 2 2 2 1 ACT domain HrpE PF06188.12 ORX50964.1 - 0.048 13.5 0.1 0.085 12.7 0.1 1.3 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF3247 PF11607.8 ORX50964.1 - 0.065 13.5 0.1 0.2 11.9 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3247) TMEM101 PF15111.6 ORX50965.1 - 0.031 13.8 0.1 0.033 13.7 0.1 1.1 1 0 0 1 1 1 0 TMEM101 protein family DUF202 PF02656.15 ORX50965.1 - 0.082 13.4 0.3 0.12 12.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF202) Prp18 PF02840.15 ORX50966.1 - 5.3e-58 195.1 0.3 5.3e-58 195.1 0.3 2.3 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 ORX50966.1 - 1.7e-09 37.0 0.8 3.9e-09 35.9 0.8 1.7 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like TraV PF09676.10 ORX50966.1 - 0.67 10.9 13.2 4 8.4 0.4 2.5 1 1 1 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) Methyltransf_23 PF13489.6 ORX50967.1 - 1.4e-18 67.3 0.0 1.8e-18 66.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX50967.1 - 9.7e-16 58.3 0.0 2.6e-15 57.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX50967.1 - 1.6e-13 51.2 0.0 3.6e-13 50.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX50967.1 - 6.4e-11 42.8 0.0 1.5e-10 41.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX50967.1 - 2.9e-09 36.9 0.0 4.2e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX50967.1 - 4.1e-05 23.2 0.0 8.4e-05 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX50967.1 - 0.00076 19.0 0.0 0.0028 17.1 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 ORX50967.1 - 0.0019 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family DOT1 PF08123.13 ORX50967.1 - 0.11 12.1 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Histone methylation protein DOT1 DUF2012 PF09430.10 ORX50968.1 - 1.8e-27 95.9 0.0 3e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) GED PF02212.18 ORX50968.1 - 0.00063 19.9 1.8 0.001 19.2 1.8 1.2 1 0 0 1 1 1 1 Dynamin GTPase effector domain CarboxypepD_reg PF13620.6 ORX50968.1 - 0.0036 17.5 0.0 0.0063 16.8 0.0 1.4 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain UIM PF02809.20 ORX50971.1 - 0.084 12.8 0.8 0.16 11.9 0.8 1.5 1 0 0 1 1 1 0 Ubiquitin interaction motif AKAP7_NLS PF10469.9 ORX50975.1 - 1.4e-08 34.9 0.0 0.0028 17.6 0.0 2.2 1 1 1 2 2 2 2 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX50975.1 - 0.04 13.8 0.1 7.8 6.4 0.0 2.2 2 0 0 2 2 2 0 2'-5' RNA ligase superfamily zf-CCHC PF00098.23 ORX50977.1 - 5e-06 26.3 7.6 0.00015 21.7 0.7 2.5 2 0 0 2 2 2 2 Zinc knuckle zf-C2H2_10 PF16588.5 ORX50977.1 - 0.0056 16.4 8.9 0.094 12.5 0.7 2.6 2 0 0 2 2 2 2 C2H2 zinc-finger zf-CCHC_3 PF13917.6 ORX50977.1 - 0.063 13.3 3.7 2.4 8.2 0.3 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ORX50977.1 - 0.15 11.9 7.5 1.5 8.6 0.7 2.3 2 0 0 2 2 2 0 Zinc knuckle UIM PF02809.20 ORX50980.1 - 0.0038 17.0 4.4 0.0087 15.9 4.4 1.6 1 0 0 1 1 1 1 Ubiquitin interaction motif zf-C2H2_12 PF18658.1 ORX50980.1 - 0.7 9.5 3.1 0.41 10.2 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger C2H2-type AKAP7_NLS PF10469.9 ORX50983.1 - 0.081 12.8 0.1 0.082 12.8 0.1 1.1 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain Glyco_transf_8 PF01501.20 ORX50984.1 - 6.9e-17 61.8 0.1 1.1e-16 61.2 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 8 Transferase PF02458.15 ORX50985.1 - 5e-21 74.9 0.0 6.2e-21 74.5 0.0 1.0 1 0 0 1 1 1 1 Transferase family WD40 PF00400.32 ORX50986.1 - 2.4e-27 94.6 15.1 0.00066 20.4 0.0 11.2 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX50986.1 - 1.8e-09 37.8 0.1 0.12 12.7 0.0 6.5 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX50986.1 - 0.036 13.4 0.1 1.4 8.2 0.1 3.0 2 1 1 3 3 3 0 WD40-like domain Tropomyosin_1 PF12718.7 ORX50987.1 - 4.5e-19 69.0 27.5 2.1e-18 66.9 27.5 1.9 1 1 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 ORX50987.1 - 1.4e-08 34.4 29.4 1.7e-08 34.2 29.4 1.0 1 0 0 1 1 1 1 Tropomyosin Cast PF10174.9 ORX50987.1 - 0.00018 19.9 16.9 0.00024 19.5 16.9 1.2 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Fez1 PF06818.15 ORX50987.1 - 0.0012 19.4 19.3 0.0012 19.4 19.3 1.7 1 1 0 1 1 1 1 Fez1 FlaC_arch PF05377.11 ORX50987.1 - 0.0015 18.9 17.8 0.17 12.3 2.1 3.4 2 1 1 3 3 3 2 Flagella accessory protein C (FlaC) GAS PF13851.6 ORX50987.1 - 0.0016 17.8 25.2 0.0081 15.5 25.2 2.0 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding MscS_porin PF12795.7 ORX50987.1 - 0.0021 17.6 20.7 0.0025 17.4 20.7 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain CENP-F_leu_zip PF10473.9 ORX50987.1 - 0.0021 18.1 31.6 0.041 13.9 11.3 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ORX50987.1 - 0.0023 18.2 27.1 0.0076 16.5 27.1 1.8 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) WXG100 PF06013.12 ORX50987.1 - 0.0031 17.7 10.8 1.9 8.8 0.5 3.1 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Tup_N PF08581.10 ORX50987.1 - 0.0044 17.3 7.0 0.0044 17.3 7.0 2.2 1 1 1 2 2 2 1 Tup N-terminal Spc7 PF08317.11 ORX50987.1 - 0.0045 15.9 26.5 0.0053 15.7 26.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein NPV_P10 PF05531.12 ORX50987.1 - 0.0052 17.2 8.2 0.72 10.4 0.2 3.1 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein FPP PF05911.11 ORX50987.1 - 0.0073 14.6 26.2 0.0081 14.4 26.2 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil ABC_tran_CTD PF16326.5 ORX50987.1 - 0.0083 16.3 13.3 0.0083 16.3 13.3 3.7 1 1 3 4 4 4 1 ABC transporter C-terminal domain Laminin_II PF06009.12 ORX50987.1 - 0.0086 16.1 15.4 0.023 14.7 9.0 2.1 1 1 1 2 2 2 2 Laminin Domain II DUF745 PF05335.13 ORX50987.1 - 0.0098 15.6 11.5 0.0098 15.6 11.5 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF745) DUF4472 PF14739.6 ORX50987.1 - 0.011 16.4 15.2 0.011 16.4 15.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) IFT57 PF10498.9 ORX50987.1 - 0.013 14.5 17.0 0.019 13.9 17.0 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Med4 PF10018.9 ORX50987.1 - 0.015 15.0 19.6 0.12 12.0 9.0 2.2 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF3450 PF11932.8 ORX50987.1 - 0.016 14.5 20.3 0.13 11.5 20.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4200 PF13863.6 ORX50987.1 - 0.018 15.5 20.4 0.018 15.5 20.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Uso1_p115_C PF04871.13 ORX50987.1 - 0.018 15.4 30.4 0.1 13.0 25.0 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region XhlA PF10779.9 ORX50987.1 - 0.019 15.1 4.3 0.019 15.1 4.3 3.0 2 1 1 3 3 3 0 Haemolysin XhlA DUF4763 PF15960.5 ORX50987.1 - 0.022 14.1 12.7 0.013 14.9 10.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) TPR_MLP1_2 PF07926.12 ORX50987.1 - 0.026 14.6 30.3 0.79 9.8 16.7 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Alanine_zipper PF11839.8 ORX50987.1 - 0.026 14.9 11.1 0.23 11.9 1.3 2.5 2 1 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DUF1664 PF07889.12 ORX50987.1 - 0.026 14.6 9.9 0.092 12.8 2.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) V-ATPase_C PF03223.15 ORX50987.1 - 0.029 13.8 7.6 0.019 14.4 4.5 1.9 1 1 1 2 2 2 0 V-ATPase subunit C DUF948 PF06103.11 ORX50987.1 - 0.034 14.4 9.9 1.1 9.6 0.9 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) HalX PF08663.10 ORX50987.1 - 0.047 14.0 27.7 1.5 9.2 11.7 3.8 1 1 2 3 3 3 0 HalX domain KLRAQ PF10205.9 ORX50987.1 - 0.061 13.6 15.9 0.14 12.4 9.7 2.1 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein XLF PF09302.11 ORX50987.1 - 0.065 13.4 10.5 0.3 11.2 10.5 1.8 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component BLOC1_2 PF10046.9 ORX50987.1 - 0.071 13.4 16.8 0.52 10.6 9.1 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF641 PF04859.12 ORX50987.1 - 0.078 13.3 19.7 0.48 10.8 6.6 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) GBR_NSP5 PF17580.2 ORX50987.1 - 0.078 12.8 3.8 0.098 12.5 3.8 1.2 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 EzrA PF06160.12 ORX50987.1 - 0.082 11.1 20.7 0.32 9.1 20.7 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA TolA_bind_tri PF16331.5 ORX50987.1 - 0.084 13.0 15.1 0.4 10.8 2.8 2.8 2 1 1 3 3 3 0 TolA binding protein trimerisation Lebercilin PF15619.6 ORX50987.1 - 0.088 12.5 28.9 0.17 11.5 22.7 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4407 PF14362.6 ORX50987.1 - 0.098 12.0 17.3 0.11 11.9 17.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ORX50987.1 - 0.1 12.8 11.9 0.2 11.8 8.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ADIP PF11559.8 ORX50987.1 - 0.11 12.6 23.7 1.7 8.7 9.5 2.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding FliD_C PF07195.12 ORX50987.1 - 0.11 11.9 9.1 1.1 8.7 0.6 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus CLZ PF16526.5 ORX50987.1 - 0.12 12.8 23.7 1.1 9.7 6.4 2.8 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF812 PF05667.11 ORX50987.1 - 0.12 11.2 24.6 0.52 9.1 24.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Lectin_N PF03954.14 ORX50987.1 - 0.12 12.1 12.9 1.6 8.5 6.0 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Golgin_A5 PF09787.9 ORX50987.1 - 0.13 11.8 23.7 0.14 11.6 23.7 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 KELK PF15796.5 ORX50987.1 - 0.13 12.7 24.1 0.079 13.4 15.3 2.7 1 1 2 3 3 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PI3K_P85_iSH2 PF16454.5 ORX50987.1 - 0.14 11.8 20.4 0.21 11.2 5.9 2.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain T3SSipB PF16535.5 ORX50987.1 - 0.15 12.5 14.6 0.28 11.7 5.5 2.1 1 1 1 2 2 2 0 Type III cell invasion protein SipB BRE1 PF08647.11 ORX50987.1 - 0.16 12.0 25.9 0.064 13.3 16.6 2.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase TMPIT PF07851.13 ORX50987.1 - 0.19 11.0 12.8 0.23 10.7 12.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF2461 PF09365.10 ORX50987.1 - 0.19 11.7 4.6 0.22 11.4 4.6 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein (DUF2461) Striatin PF08232.12 ORX50987.1 - 0.19 12.3 15.2 0.85 10.2 15.2 1.8 1 1 0 1 1 1 0 Striatin family Sec34 PF04136.15 ORX50987.1 - 0.21 11.4 15.2 3.5 7.5 7.8 2.8 1 1 1 2 2 2 0 Sec34-like family BST2 PF16716.5 ORX50987.1 - 0.25 12.0 23.2 1.4 9.6 12.6 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF724 PF05266.14 ORX50987.1 - 0.25 11.1 21.7 0.09 12.6 8.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Exonuc_VII_L PF02601.15 ORX50987.1 - 0.26 10.8 14.9 0.28 10.7 14.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mod_r PF07200.13 ORX50987.1 - 0.3 11.2 24.3 10 6.2 24.3 2.2 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF2203 PF09969.9 ORX50987.1 - 0.32 11.7 15.7 1 10.1 5.6 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 ORX50987.1 - 0.34 11.6 18.3 1 10.0 2.3 3.1 1 1 2 3 3 3 0 SlyX DHR10 PF18595.1 ORX50987.1 - 0.37 10.8 30.4 1.8 8.7 13.3 2.6 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Prefoldin_2 PF01920.20 ORX50987.1 - 0.39 10.7 26.7 1.2 9.1 6.5 3.3 1 1 2 3 3 3 0 Prefoldin subunit HIP1_clath_bdg PF16515.5 ORX50987.1 - 0.39 11.3 25.1 4.6 7.9 10.8 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 HMMR_N PF15905.5 ORX50987.1 - 0.42 10.0 25.5 0.58 9.6 25.5 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal PspA_IM30 PF04012.12 ORX50987.1 - 0.43 10.1 25.4 0.9 9.1 11.7 2.2 1 1 1 2 2 2 0 PspA/IM30 family DUF5082 PF16888.5 ORX50987.1 - 0.44 10.8 14.9 0.92 9.8 14.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) SHE3 PF17078.5 ORX50987.1 - 0.45 10.2 20.5 0.54 9.9 10.8 2.1 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Exonuc_VII_S PF02609.16 ORX50987.1 - 0.69 10.0 19.7 0.49 10.5 4.0 3.5 2 1 1 3 3 3 0 Exonuclease VII small subunit DUF489 PF04356.12 ORX50987.1 - 0.7 9.9 7.4 2.1 8.3 5.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF489) DUF4201 PF13870.6 ORX50987.1 - 0.7 9.6 23.1 4.6 6.9 19.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF3552 PF12072.8 ORX50987.1 - 0.73 9.2 24.9 1.8 8.0 24.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) FmiP_Thoc5 PF09766.9 ORX50987.1 - 0.77 9.0 18.8 0.68 9.2 8.6 2.0 1 1 1 2 2 2 0 Fms-interacting protein/Thoc5 GrpE PF01025.19 ORX50987.1 - 0.85 9.3 25.6 1 9.0 8.3 2.2 1 1 1 2 2 2 0 GrpE HrpB7 PF09486.10 ORX50987.1 - 0.97 9.8 17.7 82 3.5 17.7 2.4 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) LMBR1 PF04791.16 ORX50987.1 - 0.98 8.2 13.3 1.1 8.0 13.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2730 PF10805.8 ORX50987.1 - 1 9.5 13.1 28 4.9 6.7 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Dcc1 PF09724.9 ORX50987.1 - 1.1 8.5 12.2 1.4 8.1 12.2 1.1 1 0 0 1 1 1 0 Sister chromatid cohesion protein Dcc1 Sec2p PF06428.11 ORX50987.1 - 1.1 9.2 24.8 3.3 7.7 7.2 3.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p OmpH PF03938.14 ORX50987.1 - 1.2 9.5 23.2 95 3.3 23.2 2.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Nsp1_C PF05064.13 ORX50987.1 - 1.2 9.0 18.5 16 5.3 0.9 2.8 1 1 1 2 2 2 0 Nsp1-like C-terminal region HAUS-augmin3 PF14932.6 ORX50987.1 - 1.2 8.6 24.7 0.19 11.2 13.7 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Mt_ATP-synt_D PF05873.12 ORX50987.1 - 1.2 8.9 10.6 2 8.2 10.6 1.4 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Atg14 PF10186.9 ORX50987.1 - 1.3 8.0 19.9 1.2 8.2 12.0 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Swi5 PF07061.11 ORX50987.1 - 1.4 9.1 23.6 0.97 9.6 3.1 3.2 2 1 1 3 3 3 0 Swi5 DUF3584 PF12128.8 ORX50987.1 - 1.5 6.2 22.2 1.7 6.0 22.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 ORX50987.1 - 1.6 9.2 37.4 5.2 7.6 15.9 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region ERM PF00769.19 ORX50987.1 - 1.8 8.3 33.4 2.6 7.8 33.4 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DASH_Hsk3 PF08227.11 ORX50987.1 - 1.9 8.9 9.0 0.7 10.3 1.7 3.2 2 2 1 3 3 3 0 DASH complex subunit Hsk3 like TMF_DNA_bd PF12329.8 ORX50987.1 - 1.9 8.6 32.6 4.4 7.4 7.6 3.1 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding FAM76 PF16046.5 ORX50987.1 - 1.9 7.8 14.9 3.2 7.0 14.9 1.4 1 1 0 1 1 1 0 FAM76 protein DUF16 PF01519.16 ORX50987.1 - 1.9 9.0 15.4 16 6.0 8.6 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF2968 PF11180.8 ORX50987.1 - 2 8.0 16.4 0.59 9.7 5.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Seryl_tRNA_N PF02403.22 ORX50987.1 - 2 8.7 24.4 2.3 8.5 5.3 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 ORX50987.1 - 2 6.9 19.9 0.56 8.8 11.6 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A YscO-like PF16789.5 ORX50987.1 - 2.1 8.4 21.3 2.6 8.1 21.3 1.2 1 0 0 1 1 1 0 YscO-like protein SpecificRecomb PF10136.9 ORX50987.1 - 2.1 6.5 8.1 2.2 6.5 8.1 1.1 1 0 0 1 1 1 0 Site-specific recombinase Phage_GPO PF05929.11 ORX50987.1 - 2.4 7.7 16.5 5 6.7 16.5 1.5 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase MCC-bdg_PDZ PF10506.9 ORX50987.1 - 2.4 8.2 17.2 0.86 9.7 6.8 2.8 2 2 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Occludin_ELL PF07303.13 ORX50987.1 - 2.4 8.9 14.0 6.4 7.6 4.4 2.6 1 1 0 2 2 2 0 Occludin homology domain HemX PF04375.14 ORX50987.1 - 2.4 7.3 18.8 1.3e+02 1.6 18.8 2.0 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Prefoldin PF02996.17 ORX50987.1 - 2.6 8.0 21.6 3.5 7.5 2.1 3.2 1 1 2 3 3 3 0 Prefoldin subunit DUF4337 PF14235.6 ORX50987.1 - 2.9 8.0 20.6 6.7 6.8 9.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DivIC PF04977.15 ORX50987.1 - 3.1 7.6 25.1 4.1 7.2 4.1 3.3 1 1 1 2 2 1 0 Septum formation initiator Baculo_F PF12259.8 ORX50987.1 - 3.3 6.1 7.6 1.6 7.1 4.1 1.8 1 1 1 2 2 2 0 Baculovirus F protein ZnuA PF01297.17 ORX50987.1 - 3.4 7.0 12.6 1 8.7 1.6 2.2 1 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic COG2 PF06148.11 ORX50987.1 - 3.8 7.6 15.8 4.4 7.4 7.6 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TMF_TATA_bd PF12325.8 ORX50987.1 - 4.2 7.6 26.7 21 5.4 25.5 2.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Tho2 PF11262.8 ORX50987.1 - 4.5 6.4 18.0 0.41 9.8 9.1 2.0 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Jnk-SapK_ap_N PF09744.9 ORX50987.1 - 5.3 7.2 28.6 51 4.0 28.6 2.0 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Prefoldin_3 PF13758.6 ORX50987.1 - 6 7.0 13.4 4 7.5 1.8 2.9 1 1 1 2 2 2 0 Prefoldin subunit DUF4298 PF14131.6 ORX50987.1 - 6.9 6.7 13.3 24 5.0 4.9 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4298) Spc24 PF08286.11 ORX50987.1 - 7.4 6.9 26.5 4.6 7.5 4.2 3.1 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 UPF0242 PF06785.11 ORX50987.1 - 7.6 6.6 26.5 38 4.3 26.5 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4795 PF16043.5 ORX50987.1 - 7.9 6.0 19.7 1.3e+02 2.1 19.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4806 PF16064.5 ORX50987.1 - 7.9 6.9 8.8 0.46 10.8 0.9 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4806) NBP1 PF08537.10 ORX50987.1 - 8.3 5.7 15.2 0.45 9.9 6.9 2.0 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 Cluap1 PF10234.9 ORX50987.1 - 8.5 5.7 21.0 17 4.7 8.3 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 TFR_dimer PF04253.15 ORX50987.1 - 8.9 6.4 8.9 1.4 9.0 2.3 2.1 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain AAA_13 PF13166.6 ORX50987.1 - 9.4 4.7 21.2 12 4.4 9.2 1.8 1 1 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 ORX50988.1 - 1.3e-21 76.5 0.1 1.7e-06 28.1 0.0 3.5 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX50988.1 - 4.3e-08 33.3 2.6 0.022 15.0 0.5 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX50988.1 - 0.00026 20.8 14.0 0.015 15.2 0.3 4.0 4 0 0 4 4 4 2 Myb DNA-binding like FAM176 PF14851.6 ORX50988.1 - 4.6 6.9 6.5 37 4.0 4.3 2.9 2 0 0 2 2 2 0 FAM176 family Mito_carr PF00153.27 ORX50990.1 - 7.7e-41 137.9 0.0 3.4e-20 71.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Myb_DNA-binding PF00249.31 ORX50991.1 - 8.6e-05 22.6 0.1 0.00014 22.0 0.1 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ORX50991.1 - 0.0046 16.8 0.2 0.0078 16.1 0.2 1.3 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 ORX50991.1 - 0.019 15.2 0.2 0.031 14.5 0.2 1.3 1 0 0 1 1 1 0 Myb-like DNA-binding domain SRP14 PF02290.15 ORX50992.1 - 6.1e-20 71.4 0.1 6.1e-20 71.4 0.1 1.4 2 0 0 2 2 2 1 Signal recognition particle 14kD protein Mito_carr PF00153.27 ORX50993.1 - 3.8e-66 219.1 0.0 1.2e-21 76.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HECT PF00632.25 ORX50995.1 - 6.1e-84 282.1 0.0 9.2e-84 281.5 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Peptidase_C58 PF03543.14 ORX50995.1 - 0.21 11.3 1.5 0.39 10.4 1.5 1.3 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen PFK PF00365.20 ORX50996.1 - 4.6e-191 633.2 3.2 3.1e-103 345.0 1.3 2.2 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 ORX50996.1 - 0.11 12.2 0.1 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Glyco_hydro_47 PF01532.20 ORX50997.1 - 7.4e-152 506.4 0.0 8.5e-152 506.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Lar_restr_allev PF14354.6 ORX50998.1 - 0.072 13.5 0.0 0.18 12.2 0.0 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar Exo_endo_phos_2 PF14529.6 ORX51163.1 - 2.1e-05 24.3 0.5 2.1e-05 24.3 0.5 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ORX51163.1 - 0.00047 19.7 0.1 0.00069 19.2 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Dpy-30 PF05186.13 ORX51164.1 - 3.6e-15 55.4 0.1 4.1e-15 55.2 0.1 1.1 1 0 0 1 1 1 1 Dpy-30 motif zf-RVT PF13966.6 ORX51165.1 - 2.2e-10 41.1 1.8 3.9e-10 40.3 1.4 1.5 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Tube PF17212.3 ORX51169.1 - 0.018 15.1 0.1 0.031 14.3 0.1 1.3 1 0 0 1 1 1 0 Tail tubular protein DUF1574 PF07611.11 ORX51169.1 - 0.098 12.0 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) GHL13 PF14883.6 ORX51169.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 RVT_1 PF00078.27 ORX51170.1 - 8.5e-05 22.2 0.0 8.7e-05 22.1 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Dev_Cell_Death PF10539.9 ORX51170.1 - 0.18 11.7 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Development and cell death domain Exostosin PF03016.15 ORX51173.1 - 8.6e-37 127.0 0.1 1.1e-36 126.7 0.1 1.1 1 0 0 1 1 1 1 Exostosin family Glyco_transf_10 PF00852.19 ORX51173.1 - 0.032 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 10 (fucosyltransferase) C-term Tcp11 PF05794.13 ORX51174.1 - 2e-61 208.4 4.5 2e-61 208.4 4.5 2.8 2 1 0 3 3 3 1 T-complex protein 11 OrfB_Zn_ribbon PF07282.11 ORX51175.1 - 2.9e-09 36.7 1.2 4.7e-09 36.0 1.2 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TusA PF01206.17 ORX51175.1 - 0.053 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Sulfurtransferase TusA Sel1 PF08238.12 ORX51177.1 - 1.5e-28 98.6 11.8 6.9e-07 29.7 0.6 6.7 6 1 0 6 6 6 6 Sel1 repeat PapG_N PF03627.13 ORX51177.1 - 0.044 13.4 0.1 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 PapG carbohydrate binding domain Ribonuc_L-PSP PF01042.21 ORX51178.1 - 9e-46 154.8 0.1 1e-45 154.7 0.1 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP YjgF_endoribonc PF14588.6 ORX51178.1 - 0.052 13.7 0.0 0.054 13.6 0.0 1.2 1 0 0 1 1 1 0 YjgF/chorismate_mutase-like, putative endoribonuclease Eclosion PF04736.12 ORX51178.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone BOP1NT PF08145.12 ORX51179.1 - 2.6e-110 368.4 10.6 3.4e-110 368.1 10.6 1.1 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 ORX51179.1 - 2.1e-29 101.2 6.1 3e-07 31.0 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX51179.1 - 4.4e-08 33.3 0.1 0.0002 21.6 0.0 4.3 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Frtz PF11768.8 ORX51179.1 - 0.0004 18.8 0.0 0.24 9.7 0.0 2.3 2 0 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz DUF3727 PF12527.8 ORX51179.1 - 0.17 12.1 0.1 3 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3727) EPSP_synthase PF00275.20 ORX51180.1 - 2.5e-115 385.5 0.0 3.9e-85 286.1 0.0 2.2 1 1 1 2 2 2 2 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 ORX51180.1 - 2e-94 315.6 0.0 3.8e-94 314.7 0.0 1.5 1 0 0 1 1 1 1 3-dehydroquinate synthase DHquinase_I PF01487.15 ORX51180.1 - 5.5e-50 170.8 0.0 1.3e-49 169.5 0.0 1.7 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 ORX51180.1 - 3.3e-32 111.8 0.0 7.5e-32 110.6 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase Shikimate_dh_N PF08501.11 ORX51180.1 - 6.7e-24 84.0 0.1 2.5e-23 82.1 0.0 2.0 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 ORX51180.1 - 4.8e-10 39.0 0.0 1.2e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 ORX51180.1 - 4.8e-05 23.4 0.0 0.00012 22.2 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Fe-ADH_2 PF13685.6 ORX51180.1 - 6.1e-05 22.8 0.1 0.00018 21.3 0.1 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase AAA_18 PF13238.6 ORX51180.1 - 0.0087 16.6 0.0 0.019 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX51180.1 - 0.018 15.1 0.0 0.037 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX51180.1 - 0.024 14.8 0.0 0.051 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX51180.1 - 0.044 14.2 0.0 0.094 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 ORX51180.1 - 0.1 12.5 0.2 2.7 7.9 0.0 2.5 2 0 0 2 2 2 0 NTPase LSM PF01423.22 ORX51181.1 - 7.2e-17 60.8 0.0 1e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX51181.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Glutaredoxin PF00462.24 ORX51182.1 - 5.2e-33 113.1 0.0 4.1e-16 58.9 0.0 2.7 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 ORX51182.1 - 3.5e-07 30.2 0.0 9.7e-07 28.7 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 ORX51182.1 - 0.00035 20.5 0.1 0.035 14.1 0.0 3.1 4 0 0 4 4 4 1 Hydrogenase-1 expression protein HyaE SH3BGR PF04908.15 ORX51182.1 - 0.00078 19.6 0.0 0.17 12.0 0.0 2.5 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein RdRP PF05183.12 ORX51182.1 - 0.024 13.3 0.0 0.69 8.5 0.0 2.0 1 1 0 1 1 1 0 RNA dependent RNA polymerase Thioredoxin_2 PF13098.6 ORX51182.1 - 0.06 13.8 0.1 0.52 10.8 0.0 2.5 3 1 0 3 3 3 0 Thioredoxin-like domain DUF5381 PF17353.2 ORX51182.1 - 0.11 12.3 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Thioredoxin_3 PF13192.6 ORX51182.1 - 0.16 12.0 0.0 0.56 10.3 0.0 1.9 2 0 0 2 2 2 0 Thioredoxin domain COX16 PF14138.6 ORX51183.1 - 2.6e-29 101.5 0.2 3.2e-29 101.3 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 TMEM169 PF15052.6 ORX51183.1 - 0.19 11.9 0.0 0.22 11.6 0.0 1.3 1 1 0 1 1 1 0 TMEM169 protein family EF_TS PF00889.19 ORX51184.1 - 2.5e-33 115.5 0.2 1.5e-24 86.8 0.1 2.3 1 1 1 2 2 2 2 Elongation factor TS HBS1_N PF08938.10 ORX51184.1 - 0.081 13.2 0.1 2.3 8.6 0.1 2.5 2 0 0 2 2 2 0 HBS1 N-terminus TOM13 PF08219.11 ORX51185.1 - 3.1e-18 65.5 0.2 4.2e-18 65.1 0.2 1.2 1 0 0 1 1 1 1 Outer membrane protein TOM13 XG_FTase PF03254.13 ORX51186.1 - 3.2e-09 36.0 0.1 0.0004 19.1 0.0 2.6 2 1 1 3 3 3 2 Xyloglucan fucosyltransferase AAA_11 PF13086.6 ORX51187.1 - 4.3e-06 26.7 0.0 4.3e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX51187.1 - 5.7e-05 22.9 0.1 0.00023 21.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX51187.1 - 0.00069 20.0 0.0 0.0017 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ORX51187.1 - 0.002 18.5 0.0 0.024 15.1 0.0 2.6 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ResIII PF04851.15 ORX51187.1 - 0.0049 16.9 0.0 0.033 14.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ORX51187.1 - 0.0086 15.3 0.0 2.2 7.4 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ORX51187.1 - 0.0091 16.3 0.0 0.029 14.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX51187.1 - 0.012 16.0 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ORX51187.1 - 0.023 14.7 1.6 3.3 7.8 0.0 3.4 3 0 0 3 3 3 0 AAA domain PhoH PF02562.16 ORX51187.1 - 0.025 14.0 0.0 0.044 13.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein RNA_helicase PF00910.22 ORX51187.1 - 0.089 13.2 0.1 1.4 9.3 0.0 3.0 3 0 0 3 3 3 0 RNA helicase NTPase_1 PF03266.15 ORX51187.1 - 0.17 11.8 0.0 0.38 10.7 0.0 1.5 1 0 0 1 1 1 0 NTPase LRR_8 PF13855.6 ORX51190.1 - 3.2e-13 49.2 32.2 4.3e-09 36.0 12.9 3.9 3 2 1 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ORX51190.1 - 1.1e-11 44.8 22.4 0.0022 18.4 0.2 4.6 2 1 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX51190.1 - 1.1e-06 28.2 6.2 0.0004 19.9 1.2 3.3 1 1 2 3 3 3 3 Leucine-rich repeat LRR_1 PF00560.33 ORX51190.1 - 0.32 11.7 16.5 15 6.7 1.3 6.8 5 2 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 ORX51190.1 - 1.7 8.9 18.2 6.8 7.0 0.7 5.4 5 0 0 5 5 5 0 Leucine Rich repeat GWT1 PF06423.12 ORX51191.1 - 2.5e-33 115.3 0.7 2.5e-33 115.3 0.7 3.0 3 1 1 4 4 4 1 GWT1 SNF2_N PF00176.23 ORX51192.1 - 1.2e-64 218.2 2.4 2.2e-64 217.4 2.4 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX51192.1 - 1.1e-20 74.0 0.0 4.6e-20 72.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 ORX51192.1 - 4.1e-20 71.4 1.6 2.2e-12 46.7 0.0 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DUF4208 PF13907.6 ORX51192.1 - 1.1e-12 48.2 0.1 5.4e-12 46.0 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) ResIII PF04851.15 ORX51192.1 - 6.9e-10 39.2 0.0 2.1e-09 37.6 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 ORX51192.1 - 3.3e-06 27.4 3.3 2.7e-05 24.5 0.1 3.3 2 0 0 2 2 2 1 Chromodomain helicase DNA-binding domain 1 DEAD PF00270.29 ORX51192.1 - 1.5e-05 24.8 0.0 3.3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase SLIDE PF09111.10 ORX51192.1 - 0.0044 17.0 0.1 0.025 14.6 0.0 2.4 2 0 0 2 2 2 1 SLIDE DUF2151 PF10221.9 ORX51194.1 - 9.8e-09 34.4 2.0 1.5e-07 30.4 0.1 2.0 2 0 0 2 2 2 2 Cell cycle and development regulator Peptidase_S10 PF00450.22 ORX51196.1 - 8.4e-124 414.2 0.1 1.1e-123 413.8 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Pkinase PF00069.25 ORX51197.1 - 7e-76 255.1 0.0 9.3e-76 254.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51197.1 - 2.8e-38 131.7 0.0 4e-38 131.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 ORX51197.1 - 5.2e-18 65.6 0.2 7.5e-17 61.9 0.2 2.5 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Kinase-like PF14531.6 ORX51197.1 - 2.2e-08 33.7 0.0 3.3e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like UBA_2 PF08587.11 ORX51197.1 - 5.4e-05 23.2 0.0 0.00011 22.2 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) RIO1 PF01163.22 ORX51197.1 - 0.00069 19.3 0.5 0.0012 18.5 0.5 1.3 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 ORX51197.1 - 0.0062 15.4 0.1 0.0087 14.9 0.1 1.1 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC KA1 PF02149.19 ORX51197.1 - 0.0074 16.1 0.1 0.34 10.7 0.0 2.8 3 0 0 3 3 3 1 Kinase associated domain 1 APH PF01636.23 ORX51197.1 - 0.015 15.2 0.1 0.03 14.2 0.1 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX51197.1 - 0.025 13.5 0.2 0.025 13.5 0.2 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Kdo PF06293.14 ORX51197.1 - 0.03 13.7 0.1 0.051 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YchF-GTPase_C PF06071.13 ORX51198.1 - 1.5e-37 127.6 0.1 4.5e-37 126.1 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ORX51198.1 - 3.1e-21 75.6 0.0 1.1e-20 73.8 0.0 1.8 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX51198.1 - 3.7e-08 33.1 0.0 1.5e-07 31.1 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B zf-RING_2 PF13639.6 ORX51200.1 - 4.3e-14 52.6 7.2 9e-14 51.5 7.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX51200.1 - 6.4e-11 41.9 7.2 1.3e-10 41.0 7.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX51200.1 - 2e-10 40.4 4.9 4.2e-10 39.3 4.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX51200.1 - 1e-08 35.0 4.0 2e-08 34.0 4.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX51200.1 - 1.3e-07 31.6 2.7 1.3e-07 31.6 2.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX51200.1 - 1.1e-06 28.4 7.4 2e-06 27.5 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX51200.1 - 1.1e-05 25.7 5.3 3.2e-05 24.1 5.3 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ORX51200.1 - 1.2e-05 24.9 2.3 1.2e-05 24.9 2.3 1.8 2 0 0 2 2 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 ORX51200.1 - 0.00013 21.8 11.4 0.006 16.4 11.3 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ORX51200.1 - 0.00016 21.7 5.8 0.00016 21.7 5.8 2.2 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ORX51200.1 - 0.0071 16.1 7.4 0.013 15.3 7.4 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain GT87 PF09594.10 ORX51200.1 - 0.012 15.3 1.5 0.018 14.8 1.5 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 87 DUF2207 PF09972.9 ORX51200.1 - 0.062 12.0 0.0 0.084 11.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ABC_membrane_3 PF13748.6 ORX51200.1 - 0.096 11.9 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF4381 PF14316.6 ORX51200.1 - 0.12 12.6 0.6 0.23 11.7 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Phage_holin_2_4 PF16082.5 ORX51200.1 - 0.16 11.7 0.2 0.28 10.9 0.2 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like zf-ANAPC11 PF12861.7 ORX51200.1 - 0.24 11.5 5.0 0.57 10.3 5.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-P11 PF03854.14 ORX51200.1 - 0.58 9.9 8.4 3 7.6 8.4 2.3 1 1 1 2 2 2 0 P-11 zinc finger DUF202 PF02656.15 ORX51200.1 - 0.81 10.2 7.0 2.4 8.7 7.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF202) MKT1_N PF12247.8 ORX51201.1 - 0.11 12.9 0.1 8.7 6.8 0.0 2.1 1 1 1 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Chorismate_bind PF00425.18 ORX51202.1 - 2.2e-84 283.1 0.0 9.7e-84 281.0 0.0 1.8 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 ORX51202.1 - 4.4e-29 101.5 0.0 3.4e-28 98.6 0.0 2.4 3 0 0 3 3 3 1 Anthranilate synthase component I, N terminal region RasGEF PF00617.19 ORX51204.1 - 1.3e-55 188.3 0.1 1.3e-55 188.3 0.1 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ORX51204.1 - 1.1e-24 86.7 0.2 5.3e-24 84.5 0.2 2.3 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 ORX51204.1 - 6.6e-12 44.8 0.1 1.4e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 SH3 domain WW PF00397.26 ORX51204.1 - 1.2e-10 41.3 0.3 7.8e-06 25.9 0.0 2.7 2 0 0 2 2 2 2 WW domain SH3_9 PF14604.6 ORX51204.1 - 6.6e-10 38.7 0.2 1.6e-09 37.5 0.2 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX51204.1 - 1.3e-06 28.0 0.1 3e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain DUF1664 PF07889.12 ORX51204.1 - 0.11 12.5 0.4 0.45 10.5 0.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Arrestin_N PF00339.29 ORX51205.1 - 8.1e-16 58.4 0.1 5.6e-12 45.9 0.1 3.6 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX51205.1 - 1.9e-11 44.6 0.3 1.5e-07 31.9 0.1 2.5 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.11 ORX51205.1 - 0.00017 21.2 0.0 0.064 12.8 0.0 2.2 2 0 0 2 2 2 2 SpoOM protein Polyketide_cyc PF03364.20 ORX51206.1 - 1.5e-26 93.1 0.1 1.8e-26 92.9 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 ORX51206.1 - 8.8e-08 32.5 0.0 1.3e-07 32.0 0.0 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport UL41A PF17591.2 ORX51207.1 - 1.1 9.4 7.2 0.36 11.0 0.9 2.2 2 0 0 2 2 2 0 Herpesvirus UL41A ThrE PF06738.12 ORX51209.1 - 2.9e-51 174.2 19.7 4.6e-45 153.9 2.3 2.3 2 1 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX51209.1 - 8.5e-06 25.9 31.6 3.8e-05 23.8 10.3 2.3 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE zf-H2C2_2 PF13465.6 ORX51210.1 - 1.1e-10 41.4 31.5 4e-08 33.3 4.0 4.4 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 ORX51210.1 - 3.2e-09 36.7 31.6 0.0019 18.6 1.9 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ORX51210.1 - 1e-07 31.7 21.7 0.00064 19.6 0.5 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX51210.1 - 0.0002 21.9 26.6 0.07 14.0 1.0 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger DUF3450 PF11932.8 ORX51210.1 - 0.024 13.9 0.4 0.038 13.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) zf-C2H2_11 PF16622.5 ORX51210.1 - 0.075 12.8 15.8 0.11 12.3 0.1 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type Mto2_bdg PF12808.7 ORX51210.1 - 0.16 12.3 4.2 0.27 11.5 1.8 2.4 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DivIC PF04977.15 ORX51210.1 - 0.18 11.6 5.6 0.32 10.8 5.6 1.3 1 0 0 1 1 1 0 Septum formation initiator DUF3573 PF12097.8 ORX51210.1 - 0.22 10.3 0.9 0.28 9.9 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) zf-C2H2_jaz PF12171.8 ORX51210.1 - 0.32 11.3 0.1 0.32 11.3 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding bZIP_1 PF00170.21 ORX51210.1 - 0.38 10.9 2.8 3.5 7.8 0.2 2.3 1 1 1 2 2 2 0 bZIP transcription factor C1_4 PF07975.12 ORX51210.1 - 0.53 10.6 13.7 14 6.0 0.8 3.1 1 1 2 3 3 3 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.10 ORX51210.1 - 0.56 10.4 10.4 3.5 7.8 4.9 3.1 2 1 1 3 3 3 0 Zinc ribbon domain HALZ PF02183.18 ORX51210.1 - 0.61 10.4 5.1 1.1 9.6 4.1 2.0 1 1 0 1 1 1 0 Homeobox associated leucine zipper zf-met PF12874.7 ORX51210.1 - 0.82 10.2 14.3 2.1 8.9 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type BolA PF01722.18 ORX51210.1 - 2.1 8.7 7.9 4.6 7.6 0.2 2.5 1 1 1 2 2 2 0 BolA-like protein Cytochrome_C7 PF14522.6 ORX51210.1 - 3.8 7.6 28.6 2.9 8.0 17.6 3.9 2 1 3 5 5 5 0 Cytochrome c7 and related cytochrome c TSC22 PF01166.18 ORX51210.1 - 6.3 7.2 7.4 1.8 8.9 0.1 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family TPR_1 PF00515.28 ORX51211.1 - 1.3e-08 34.3 9.5 0.00036 20.2 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX51211.1 - 9.6e-08 31.6 6.3 0.001 19.0 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX51211.1 - 5.7e-05 23.6 5.1 0.27 12.2 0.1 3.8 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51211.1 - 0.00016 21.9 2.8 0.00029 21.1 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX51211.1 - 0.00057 20.3 3.5 0.00057 20.3 3.5 2.9 2 1 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX51211.1 - 0.0058 16.7 0.6 2.6 8.2 0.2 2.9 3 0 0 3 3 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 ORX51211.1 - 0.013 16.1 0.5 0.17 12.6 0.1 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX51211.1 - 0.015 15.3 0.3 0.97 9.6 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX51211.1 - 0.043 14.0 1.1 11 6.6 0.0 3.3 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX51211.1 - 0.054 14.1 4.6 9.8 7.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX51211.1 - 0.068 13.6 0.7 0.5 10.9 0.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX51211.1 - 0.071 12.8 1.0 0.12 12.1 0.1 1.9 2 0 0 2 2 2 0 TPR repeat Histone_HNS PF00816.21 ORX51211.1 - 0.078 13.8 1.0 14 6.6 0.2 2.5 1 1 1 2 2 2 0 H-NS histone family TPR_MalT PF17874.1 ORX51211.1 - 0.079 12.3 5.8 0.2 11.0 5.9 1.7 1 1 0 1 1 1 0 MalT-like TPR region MG2 PF01835.19 ORX51211.1 - 0.085 13.3 0.0 14 6.2 0.0 2.4 2 0 0 2 2 2 0 MG2 domain NYD-SP12_N PF15015.6 ORX51211.1 - 0.098 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal TPR_9 PF13371.6 ORX51211.1 - 0.86 9.8 5.5 3.2 8.0 0.4 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat zf-RING_4 PF14570.6 ORX51212.1 - 6.8e-21 73.8 11.7 1.2e-20 73.0 11.7 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-C3HC4_3 PF13920.6 ORX51212.1 - 3.1e-06 26.9 7.9 5.9e-06 26.0 7.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ORX51212.1 - 0.00029 20.6 7.8 0.019 14.8 8.2 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ORX51212.1 - 0.00099 19.4 11.8 0.00099 19.4 11.8 1.7 2 0 0 2 2 2 1 Ring finger domain RRM_1 PF00076.22 ORX51212.1 - 0.0015 18.3 0.1 0.0029 17.4 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Baculo_IE-1 PF05290.11 ORX51212.1 - 0.021 14.8 3.4 0.047 13.6 3.4 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4 PF00097.25 ORX51212.1 - 0.36 10.7 10.8 0.65 9.9 10.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-UDP PF14569.6 ORX51212.1 - 0.39 10.9 3.2 1 9.5 3.2 1.6 1 0 0 1 1 1 0 Zinc-binding RING-finger TRAPPC10 PF12584.8 ORX51213.1 - 0.03 14.0 0.1 0.051 13.3 0.1 1.4 1 0 0 1 1 1 0 Trafficking protein particle complex subunit 10, TRAPPC10 NapE PF06796.11 ORX51213.1 - 0.51 9.9 3.7 1.4 8.5 0.4 2.5 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE NMO PF03060.15 ORX51214.1 - 4.6e-55 187.3 0.9 7.7e-53 180.0 0.9 2.0 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ORX51214.1 - 7.9e-12 44.8 0.1 9e-10 38.1 0.1 2.2 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 ORX51214.1 - 0.013 15.0 0.3 0.082 12.3 0.1 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein FMN_dh PF01070.18 ORX51214.1 - 0.041 12.9 0.2 0.063 12.3 0.2 1.3 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Glu_synthase PF01645.17 ORX51214.1 - 0.11 11.6 0.2 0.19 10.9 0.2 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase EF-hand_7 PF13499.6 ORX51215.1 - 5e-24 84.5 7.3 2.6e-16 59.8 0.8 2.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ORX51215.1 - 7.6e-23 78.3 15.6 1.1e-06 27.8 0.1 5.0 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 ORX51215.1 - 2.7e-21 73.6 11.2 6.5e-06 25.7 0.2 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ORX51215.1 - 3.3e-16 57.9 14.1 5.4e-06 25.7 1.0 4.4 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 ORX51215.1 - 6.4e-15 54.7 10.0 4.4e-05 23.2 0.7 4.0 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ORX51215.1 - 2.4e-08 33.9 7.4 0.11 12.4 0.3 4.0 2 1 2 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX51215.1 - 2.1e-05 24.8 3.7 0.0043 17.3 1.0 3.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ORX51215.1 - 0.0029 17.9 0.6 1.4 9.3 0.1 3.3 2 1 1 3 3 3 1 EF-hand domain RFX_DNA_binding PF02257.15 ORX51215.1 - 0.044 14.4 0.0 1.7 9.3 0.0 2.2 2 0 0 2 2 2 0 RFX DNA-binding domain S10_plectin PF03501.15 ORX51215.1 - 0.052 13.6 0.0 0.095 12.8 0.0 1.5 1 1 0 1 1 1 0 Plectin/S10 domain EF-hand_14 PF17959.1 ORX51215.1 - 0.052 13.9 3.3 4.2 7.8 0.1 3.1 3 1 0 3 3 3 0 EF-hand domain EF-hand_2 PF09068.11 ORX51215.1 - 0.062 13.4 0.3 2.1 8.5 0.0 2.9 3 1 0 3 3 3 0 EF hand Toprim PF01751.22 ORX51215.1 - 0.078 13.2 0.1 1.9 8.8 0.1 2.4 1 1 1 2 2 2 0 Toprim domain polyprenyl_synt PF00348.17 ORX51216.1 - 6.5e-72 241.7 0.0 9e-72 241.2 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase Oxidored_nitro PF00148.19 ORX51216.1 - 0.018 13.8 0.0 0.028 13.2 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase PARP PF00644.20 ORX51217.1 - 9e-27 93.9 0.5 1.8e-24 86.4 0.1 2.6 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 ORX51217.1 - 1.6e-09 37.6 1.9 6.4e-09 35.8 1.9 2.1 1 1 0 1 1 1 1 WGR domain PARP_reg PF02877.14 ORX51217.1 - 3.8e-07 30.3 3.2 8e-07 29.2 3.2 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain Mcp5_PH PF12814.7 ORX51218.1 - 1.3e-29 102.8 0.2 6.2e-29 100.6 0.2 2.3 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 ORX51218.1 - 0.0025 18.3 0.1 0.009 16.5 0.0 2.1 2 0 0 2 2 2 1 PH domain RcsC PF09456.10 ORX51218.1 - 0.067 13.2 26.5 1.1 9.3 1.1 6.7 2 2 5 7 7 7 0 RcsC Alpha-Beta-Loop (ABL) CENP-F_leu_zip PF10473.9 ORX51218.1 - 0.67 10.0 53.6 0.21 11.6 31.2 4.9 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PPR_2 PF13041.6 ORX51219.1 - 1.4e-27 95.6 1.1 5e-06 26.6 0.0 6.0 5 2 2 7 7 7 5 PPR repeat family PPR PF01535.20 ORX51219.1 - 2.6e-24 83.7 0.5 3e-05 24.0 0.0 6.0 5 0 0 5 5 5 5 PPR repeat PPR_3 PF13812.6 ORX51219.1 - 1.8e-22 79.2 0.0 4.1e-06 26.8 0.0 5.4 4 1 0 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX51219.1 - 2.7e-21 74.9 0.1 3.6e-07 29.8 0.0 6.0 6 0 0 6 6 6 3 PPR repeat PPR_long PF17177.4 ORX51219.1 - 8.9e-17 61.2 0.7 1.9e-09 37.2 0.1 3.1 1 1 2 3 3 3 2 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 ORX51219.1 - 0.00021 21.7 0.2 0.084 13.3 0.1 3.4 2 1 1 3 3 3 1 Mitochondrial ribonuclease P subunit (RPM2) MnhB PF04039.13 ORX51220.1 - 0.055 13.8 0.9 0.097 13.0 0.9 1.4 1 1 0 1 1 1 0 Domain related to MnhB subunit of Na+/H+ antiporter BATS PF06968.13 ORX51221.1 - 1.4e-19 70.0 0.1 4.7e-19 68.3 0.1 1.9 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 ORX51221.1 - 4.7e-17 62.9 0.2 6.7e-17 62.4 0.2 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Cro PF09048.10 ORX51223.1 - 0.049 13.7 0.4 0.15 12.2 0.4 1.8 1 0 0 1 1 1 0 Cro DUF1394 PF07159.12 ORX51224.1 - 2.2e-99 332.5 0.4 2.5e-99 332.3 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) ParD_antitoxin PF03693.14 ORX51224.1 - 0.07 13.6 0.1 9.6 6.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH DHDPS PF00701.22 ORX51225.1 - 2.8e-56 190.4 0.0 3.7e-56 190.0 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Ras PF00071.22 ORX51226.1 - 1.9e-55 186.9 0.0 2.2e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX51226.1 - 8e-20 71.2 0.0 1.3e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX51226.1 - 3.8e-07 29.7 0.0 4.7e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX51226.1 - 0.00075 19.1 0.3 0.005 16.4 0.0 1.9 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX51226.1 - 0.0017 18.3 0.0 0.43 10.5 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX51226.1 - 0.01 15.4 0.2 0.076 12.5 0.2 2.3 1 1 0 1 1 1 0 Ferrous iron transport protein B CbiA PF01656.23 ORX51226.1 - 0.1 12.7 0.2 0.19 11.8 0.2 1.7 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_25 PF13481.6 ORX51226.1 - 0.12 12.0 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain CorA PF01544.18 ORX51227.1 - 8.1e-51 173.1 0.0 1.1e-50 172.6 0.0 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein RIC1 PF07064.13 ORX51228.1 - 1.3e-74 250.8 0.9 6.1e-74 248.6 0.9 2.1 1 1 0 1 1 1 1 RIC1 PD40 PF07676.12 ORX51228.1 - 0.011 15.7 0.2 0.048 13.6 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 ORX51228.1 - 0.016 15.5 0.0 1.3 9.3 0.0 3.8 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain F5_F8_type_C PF00754.25 ORX51229.1 - 0.00011 22.3 0.0 0.00017 21.7 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain ANAPC10 PF03256.16 ORX51229.1 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Sad1_UNC PF07738.13 ORX51229.1 - 0.068 13.2 0.0 0.1 12.6 0.0 1.4 1 1 0 1 1 1 0 Sad1 / UNC-like C-terminal CN_hydrolase PF00795.22 ORX51230.1 - 4.3e-22 78.7 0.0 6.8e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase adh_short PF00106.25 ORX51231.1 - 1.9e-31 109.1 0.1 2.3e-30 105.5 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX51231.1 - 2.6e-20 73.0 0.0 1.3e-19 70.8 0.0 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX51231.1 - 2.8e-08 33.9 0.0 5.3e-08 33.0 0.0 1.5 2 0 0 2 2 2 1 KR domain Redoxin PF08534.10 ORX51231.1 - 0.08 12.6 0.0 4.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Redoxin NPR3 PF03666.13 ORX51232.1 - 2.6e-54 184.8 4.6 3.2e-54 184.5 4.6 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 SUR7 PF06687.12 ORX51233.1 - 7.9e-05 22.4 3.8 0.00011 21.9 3.8 1.2 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 ORX51233.1 - 2.2 8.2 7.6 6.6 6.6 1.5 2.6 1 1 1 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 HD PF01966.22 ORX51235.1 - 1.5e-12 47.8 0.0 3.9e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 HD domain Vps52 PF04129.12 ORX51235.1 - 0.0078 15.0 0.1 0.013 14.3 0.1 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family Ca_chan_IQ PF08763.11 ORX51235.1 - 0.12 12.6 0.0 0.94 9.7 0.0 2.3 2 0 0 2 2 2 0 Voltage gated calcium channel IQ domain Peptidase_S10 PF00450.22 ORX51236.1 - 1.2e-118 397.1 1.3 1.5e-118 396.8 1.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PPR_2 PF13041.6 ORX51237.1 - 1.1e-30 105.6 1.4 2.2e-11 43.8 0.0 4.6 3 1 1 4 4 4 4 PPR repeat family PPR_3 PF13812.6 ORX51237.1 - 7.7e-26 90.0 0.2 5.5e-08 32.8 0.1 4.5 3 1 3 6 6 6 5 Pentatricopeptide repeat domain PPR PF01535.20 ORX51237.1 - 1.1e-19 69.2 2.5 0.00016 21.7 0.0 6.2 8 0 0 8 8 8 4 PPR repeat PPR_1 PF12854.7 ORX51237.1 - 1.2e-17 63.3 1.0 0.0094 15.6 0.0 6.9 8 0 0 8 8 8 5 PPR repeat PPR_long PF17177.4 ORX51237.1 - 7.5e-08 32.0 0.0 0.011 15.1 0.0 3.1 2 2 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP GATA PF00320.27 ORX51238.1 - 1.2e-17 63.2 2.9 1.7e-17 62.7 2.9 1.3 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX51238.1 - 0.00028 20.3 1.3 0.0004 19.8 1.3 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding Paired_CXXCH_1 PF09699.10 ORX51238.1 - 0.013 15.3 0.9 0.092 12.5 0.1 2.3 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) ArfGap PF01412.18 ORX51238.1 - 0.013 15.6 0.4 0.015 15.3 0.4 1.1 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Auto_anti-p27 PF06677.12 ORX51238.1 - 0.027 14.6 0.7 0.039 14.1 0.7 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-RRN7 PF11781.8 ORX51238.1 - 0.06 13.0 3.1 0.47 10.2 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF2387 PF09526.10 ORX51238.1 - 0.063 13.4 0.1 0.075 13.2 0.1 1.1 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) DZR PF12773.7 ORX51238.1 - 0.09 12.8 2.4 0.44 10.6 2.3 1.9 1 1 0 1 1 1 0 Double zinc ribbon Apocytochr_F_N PF16639.5 ORX51238.1 - 0.23 11.7 0.4 5.9 7.2 0.0 2.0 1 1 1 2 2 2 0 Apocytochrome F, N-terminal Pkinase PF00069.25 ORX51239.1 - 2.7e-39 135.1 0.0 3.8e-39 134.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51239.1 - 4.9e-19 68.6 0.0 6.2e-19 68.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX51239.1 - 0.00018 21.5 0.4 0.00069 19.6 0.2 1.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX51239.1 - 0.0013 18.4 0.0 0.0024 17.5 0.0 1.5 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kinase-like PF14531.6 ORX51239.1 - 0.0081 15.5 0.0 0.29 10.4 0.0 2.3 2 1 0 2 2 2 1 Kinase-like IspA PF04279.15 ORX51240.1 - 6.1 7.0 16.6 0.15 12.2 5.1 2.2 1 1 1 2 2 2 0 Intracellular septation protein A DUF730 PF05325.11 ORX51241.1 - 0.077 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF730) DUF747 PF05346.11 ORX51242.1 - 9e-105 350.6 5.1 1.1e-104 350.3 5.1 1.2 1 0 0 1 1 1 1 Eukaryotic membrane protein family MIT PF04212.18 ORX51244.1 - 1.6e-06 28.1 0.0 3e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF3037 PF11236.8 ORX51245.1 - 0.067 13.6 0.2 0.28 11.6 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3037) VTC PF09359.10 ORX51246.1 - 1.1e-13 51.2 3.2 1.6e-12 47.4 0.0 3.4 2 1 0 2 2 2 1 VTC domain DUF202 PF02656.15 ORX51246.1 - 2.5e-09 37.5 0.8 5.7e-09 36.3 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 ORX51246.1 - 5.4e-08 33.2 14.6 0.00015 21.8 2.8 3.2 3 1 0 4 4 4 2 SPX domain DUF2721 PF11026.8 ORX51246.1 - 0.022 14.6 1.3 0.074 12.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) VTC PF09359.10 ORX51248.1 - 1.6e-85 286.8 0.1 3.1e-85 285.9 0.1 1.5 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 ORX51248.1 - 7.6e-13 49.1 16.3 2.4e-08 34.3 1.2 4.1 2 1 2 4 4 4 3 SPX domain DUF202 PF02656.15 ORX51248.1 - 1.3e-11 44.8 3.2 2.7e-11 43.7 3.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) VCBS PF13517.6 ORX51249.1 - 4.2e-23 81.7 14.3 3.1e-07 30.9 0.2 5.4 3 2 2 5 5 5 5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 ORX51249.1 - 4e-07 30.0 9.3 0.02 15.1 0.0 6.1 6 0 0 6 6 6 2 FG-GAP repeat TcdB_toxin_midN PF12256.8 ORX51249.1 - 0.024 14.0 3.4 13 5.1 0.1 4.6 3 1 2 5 5 5 0 Insecticide toxin TcdB middle/N-terminal region DUF4381 PF14316.6 ORX51249.1 - 0.11 12.7 0.6 0.2 11.9 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2585 PF10755.9 ORX51251.1 - 0.11 12.2 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2585) NAD_binding_10 PF13460.6 ORX51254.1 - 1.5e-06 28.3 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX51254.1 - 1e-05 25.1 0.0 6.8e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX51254.1 - 2.3e-05 23.6 0.0 0.0014 17.7 0.0 2.1 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 ORX51254.1 - 0.0013 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ORX51254.1 - 0.0024 17.4 0.0 0.0036 16.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 ORX51254.1 - 0.073 12.2 0.0 0.22 10.6 0.0 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain KR PF08659.10 ORX51254.1 - 0.16 11.8 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 KR domain GDP_Man_Dehyd PF16363.5 ORX51254.1 - 0.18 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pkinase PF00069.25 ORX51255.1 - 5.8e-08 32.4 0.0 1.1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51255.1 - 0.00018 20.9 0.1 0.0013 18.0 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase DUF5621 PF18532.1 ORX51256.1 - 0.038 13.9 0.1 0.052 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5621) Polysacc_deac_1 PF01522.21 ORX51257.1 - 8.3e-23 80.6 0.1 2.7e-22 79.0 0.0 1.8 2 0 0 2 2 2 1 Polysaccharide deacetylase Polysacc_deac_1 PF01522.21 ORX51258.1 - 1.6e-22 79.7 0.0 3.3e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase CwfJ_C_1 PF04677.15 ORX51258.1 - 0.096 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 Vps51 PF08700.11 ORX51260.1 - 3.7e-13 49.3 2.9 4.1e-13 49.2 0.2 2.5 3 0 0 3 3 3 1 Vps51/Vps67 UvrD_C PF13361.6 ORX51260.1 - 0.051 12.9 1.3 0.12 11.7 1.3 1.6 1 1 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF4085 PF13315.6 ORX51260.1 - 0.11 12.1 0.0 0.27 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) MaoC_dehydratas PF01575.19 ORX51261.1 - 2.8e-25 88.3 0.0 4.8e-25 87.5 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ORX51261.1 - 3.6e-06 27.1 0.0 0.0048 17.0 0.0 2.5 2 1 0 2 2 2 2 N-terminal half of MaoC dehydratase APH PF01636.23 ORX51262.1 - 1.1e-17 64.7 0.0 1.6e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX51262.1 - 2.5e-09 36.9 0.0 4.1e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ORX51262.1 - 1.2e-05 25.0 0.0 1.7e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 ORX51262.1 - 1.2e-05 24.4 0.0 1.8e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Methyltr_RsmF_N PF17125.5 ORX51262.1 - 0.028 14.9 0.1 0.074 13.5 0.1 1.7 1 1 0 1 1 1 0 N-terminal domain of 16S rRNA methyltransferase RsmF APH PF01636.23 ORX51263.1 - 1.2e-13 51.5 0.0 1.9e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 ORX51263.1 - 1.1e-08 34.8 0.1 3.1e-08 33.3 0.0 1.7 2 0 0 2 2 2 1 Ecdysteroid kinase DUF1679 PF07914.11 ORX51263.1 - 2.1e-07 30.2 0.0 3.5e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) Choline_kinase PF01633.20 ORX51263.1 - 9.1e-06 25.4 0.0 1.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase DUF4743 PF15916.5 ORX51265.1 - 6.7e-21 74.5 0.0 9.5e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 ORX51265.1 - 7.3e-08 32.5 0.0 1.1e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain RPE65 PF03055.15 ORX51266.1 - 2.7e-91 307.1 0.3 3.3e-91 306.8 0.3 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DnaJ_C PF01556.18 ORX51267.1 - 2.4e-35 121.8 0.4 3.8e-35 121.1 0.4 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX51267.1 - 1.9e-24 85.5 5.5 3.3e-24 84.8 5.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX51267.1 - 6.8e-16 58.4 17.1 1.2e-15 57.6 17.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ORX51267.1 - 1.8e-05 24.6 7.2 0.035 14.1 1.4 2.6 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 ORX51267.1 - 0.00012 22.1 8.1 0.068 13.2 1.7 2.2 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 ORX51267.1 - 0.1 12.2 8.1 0.16 11.6 1.2 2.4 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 ORX51267.1 - 0.36 10.9 9.5 1.3 9.1 9.6 1.8 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ORX51267.1 - 2.4 8.3 13.9 24 5.2 1.5 3.7 1 1 1 3 3 3 0 Zinc ribbon domain DUF1272 PF06906.11 ORX51267.1 - 3.1 8.0 7.8 1.6 8.9 3.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) Cytochrome_CBB3 PF13442.6 ORX51267.1 - 7.3 7.0 8.1 25 5.3 1.2 2.8 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III zinc-ribbons_6 PF07191.12 ORX51267.1 - 7.8 6.6 11.7 36 4.4 2.5 2.4 1 1 1 2 2 2 0 zinc-ribbons Vpu PF00558.19 ORX51269.1 - 1.9 8.3 4.0 0.55 10.0 0.3 2.1 2 0 0 2 2 2 0 Vpu protein LMBR1 PF04791.16 ORX51270.1 - 0.039 12.9 1.5 0.047 12.6 1.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NARG2_C PF10505.9 ORX51270.1 - 0.07 12.6 1.1 0.68 9.4 0.0 2.6 3 0 0 3 3 3 0 NMDA receptor-regulated gene protein 2 C-terminus LytR_C PF13399.6 ORX51270.1 - 0.13 13.3 0.7 0.72 10.9 0.0 2.5 2 0 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator DUF4407 PF14362.6 ORX51270.1 - 0.24 10.7 8.1 0.12 11.7 6.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Pkinase PF00069.25 ORX51271.1 - 2.5e-66 223.7 0.0 3.3e-66 223.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51271.1 - 8.7e-53 179.2 0.0 1.4e-52 178.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX51271.1 - 9e-06 25.2 0.0 0.0044 16.4 0.0 2.5 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ORX51271.1 - 0.00021 20.2 0.4 0.00041 19.2 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ORX51271.1 - 0.015 14.7 0.2 0.026 13.9 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX51271.1 - 0.1 12.5 0.3 1.2 9.0 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family EloA-BP1 PF15870.5 ORX51272.1 - 2.8e-05 24.4 0.0 7.4e-05 23.1 0.0 1.6 1 1 1 2 2 2 1 ElonginA binding-protein 1 DPBB_1 PF03330.18 ORX51273.1 - 1.3e-08 35.0 0.0 1.7e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 Lytic transglycolase Ras PF00071.22 ORX51274.1 - 1e-30 106.5 0.2 1.2e-30 106.2 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX51274.1 - 3.6e-24 85.3 0.1 5.6e-24 84.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX51274.1 - 1.5e-06 27.7 0.1 1.8e-06 27.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX51274.1 - 0.0011 18.4 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 ORX51274.1 - 0.0026 16.7 1.4 0.14 10.9 0.1 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) F-box PF00646.33 ORX51275.1 - 1.2e-05 25.0 1.3 2.7e-05 23.9 0.0 2.3 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ORX51275.1 - 0.025 14.5 0.1 0.079 12.9 0.1 1.9 1 0 0 1 1 1 0 F-box-like MPLKIP PF15502.6 ORX51275.1 - 0.051 13.8 0.5 11 6.3 0.0 2.6 2 0 0 2 2 2 0 M-phase-specific PLK1-interacting protein NAM-associated PF14303.6 ORX51275.1 - 0.051 14.3 2.0 0.11 13.2 2.0 1.6 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF3584 PF12128.8 ORX51275.1 - 0.054 11.0 5.7 0.074 10.6 5.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAGA_bind PF06217.12 ORX51275.1 - 0.18 12.1 0.3 0.27 11.5 0.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family TarH PF02203.15 ORX51275.1 - 0.31 10.9 7.5 0.55 10.1 7.5 1.3 1 0 0 1 1 1 0 Tar ligand binding domain homologue DUF3053 PF11254.8 ORX51275.1 - 0.37 10.4 5.4 0.58 9.7 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3053) Phage_Gp23 PF10669.9 ORX51275.1 - 0.38 11.1 2.6 0.75 10.1 2.6 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) OrfB_Zn_ribbon PF07282.11 ORX51276.1 - 0.04 13.9 0.8 0.04 13.9 0.8 1.9 2 1 0 2 2 2 0 Putative transposase DNA-binding domain TIG_plexin PF17960.1 ORX51276.1 - 0.083 12.9 5.4 0.43 10.6 0.2 2.7 3 1 0 3 3 3 0 TIG domain zf-HC3 PF16827.5 ORX51276.1 - 0.38 11.0 5.9 0.95 9.7 5.9 1.8 1 1 0 1 1 1 0 zinc-finger PGA2 PF07543.12 ORX51277.1 - 5.6 6.9 11.3 3.7 7.5 7.2 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 RRM_1 PF00076.22 ORX51278.1 - 5.8e-07 29.2 0.0 1.2e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX51278.1 - 0.059 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RNA_bind PF08675.11 ORX51278.1 - 0.063 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 RNA binding domain E1_DerP2_DerF2 PF02221.15 ORX51278.1 - 0.073 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 ML domain NTF2 PF02136.20 ORX51279.1 - 1.6e-34 119.0 0.3 1.8e-34 118.8 0.3 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 ORX51279.1 - 0.0016 18.4 0.0 0.0019 18.2 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 BAP PF06639.11 ORX51280.1 - 0.03 14.7 1.2 0.037 14.4 0.0 1.7 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) Period_C PF12114.8 ORX51281.1 - 0.055 13.1 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Rhodanese_C PF12368.8 ORX51281.1 - 0.13 12.7 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 Rhodanase C-terminal XRN_M PF17846.1 ORX51281.1 - 0.19 10.6 0.2 0.49 9.3 0.1 1.6 1 1 1 2 2 2 0 Xrn1 helical domain CxC6 PF18721.1 ORX51284.1 - 0.27 11.5 0.3 0.27 11.5 0.3 2.8 2 1 1 3 3 3 0 CxC6 like cysteine cluster associated with KDZ transposases zinc_ribbon_12 PF11331.8 ORX51284.1 - 0.69 9.8 5.2 0.28 11.0 2.0 2.1 2 1 0 2 2 2 0 Probable zinc-ribbon domain DZR PF12773.7 ORX51284.1 - 8.3 6.5 10.7 2.9e+02 1.6 10.8 3.0 1 1 1 2 2 2 0 Double zinc ribbon Thioredoxin PF00085.20 ORX51285.1 - 2.1e-55 185.0 0.0 7.8e-27 93.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 ORX51285.1 - 4.1e-25 88.5 1.0 9.3e-25 87.4 1.0 1.6 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain OST3_OST6 PF04756.13 ORX51285.1 - 8.9e-10 38.4 0.0 0.00013 21.4 0.0 2.4 2 1 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ORX51285.1 - 1.2e-09 38.5 0.1 0.00091 19.6 0.0 3.3 2 2 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 ORX51285.1 - 4.2e-06 26.7 0.0 0.043 13.7 0.0 2.6 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 ORX51285.1 - 5.1e-06 26.7 0.0 0.052 13.9 0.0 3.0 2 1 1 3 3 3 2 Thioredoxin-like Thioredoxin_7 PF13899.6 ORX51285.1 - 6.3e-06 26.3 0.1 0.44 10.8 0.0 3.6 3 1 0 3 3 3 2 Thioredoxin-like HyaE PF07449.11 ORX51285.1 - 2.3e-05 24.3 0.0 0.27 11.2 0.0 2.7 2 0 0 2 2 2 2 Hydrogenase-1 expression protein HyaE TraF PF13728.6 ORX51285.1 - 0.0057 16.5 0.2 3.7 7.3 0.0 2.8 3 0 0 3 3 3 2 F plasmid transfer operon protein FPRL1_inhibitor PF16104.5 ORX51285.1 - 0.0066 16.6 0.9 0.098 12.8 0.0 2.4 2 0 0 2 2 2 1 Formyl peptide receptor-like 1 inhibitory protein FKBP_N PF01346.18 ORX51285.1 - 0.019 15.9 3.0 0.23 12.4 0.1 2.3 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase SET PF00856.28 ORX51287.1 - 7e-19 68.8 0.0 2.9e-18 66.8 0.0 2.1 1 1 0 1 1 1 1 SET domain AWS PF17907.1 ORX51287.1 - 4.4e-11 42.6 8.8 4.4e-11 42.6 8.8 2.3 2 0 0 2 2 2 1 AWS domain WW PF00397.26 ORX51287.1 - 2.9e-08 33.7 2.4 2.9e-08 33.7 2.4 2.3 2 0 0 2 2 2 1 WW domain SRI PF08236.11 ORX51287.1 - 3.3e-06 27.2 3.1 3.3e-06 27.2 3.1 2.0 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain BRCT PF00533.26 ORX51287.1 - 0.094 13.1 0.1 3.7 8.0 0.1 2.8 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain RRN3 PF05327.11 ORX51287.1 - 0.12 10.9 2.4 0.078 11.5 0.3 1.6 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Flavi_capsid PF01003.19 ORX51287.1 - 0.13 12.0 0.1 0.29 10.9 0.1 1.5 1 0 0 1 1 1 0 Flavivirus capsid protein C PTCB-BRCT PF12738.7 ORX51287.1 - 0.15 12.0 0.3 2.2 8.3 0.0 2.6 2 1 1 3 3 3 0 twin BRCT domain PRESAN PF09687.10 ORX51287.1 - 0.44 11.1 4.3 1.1 9.8 0.1 2.5 2 0 0 2 2 2 0 Plasmodium RESA N-terminal DUF3808 PF10300.9 ORX51288.1 - 1.4e-60 205.5 10.2 1.9e-60 205.0 9.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX51288.1 - 0.0042 17.1 0.1 4.8 7.5 0.0 4.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51288.1 - 0.024 14.9 0.0 6.6 7.1 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX51288.1 - 0.099 13.5 0.3 25 6.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 ORX51288.1 - 0.14 12.2 1.1 7.7 6.7 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 DPBB_1 PF03330.18 ORX51289.1 - 6.8e-08 32.7 0.1 1.2e-07 31.9 0.1 1.4 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX51289.1 - 2.4e-06 27.4 0.3 3e-06 27.1 0.3 1.2 1 0 0 1 1 1 1 Barwin family Paired_CXXCH_1 PF09699.10 ORX51289.1 - 0.21 11.4 1.4 0.75 9.6 1.4 1.9 1 1 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) 2-oxoacid_dh PF00198.23 ORX51290.1 - 8.2e-82 274.1 0.1 1.1e-81 273.8 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX51290.1 - 1.7e-17 63.0 1.2 3.6e-17 62.0 1.2 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ORX51290.1 - 1.6e-13 50.7 0.3 4.2e-13 49.4 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ORX51290.1 - 0.072 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 Biotin-lipoyl like O-FucT PF10250.9 ORX51291.1 - 8.2e-18 65.2 0.0 1.2e-07 31.7 0.0 2.4 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Peptidase_C48 PF02902.19 ORX51294.1 - 1.4e-45 155.8 1.1 2.3e-45 155.1 1.1 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 ORX51294.1 - 0.019 13.7 0.6 4 6.1 0.0 2.1 1 1 1 2 2 2 0 Vaccinia virus I7 processing peptidase Aldedh PF00171.22 ORX51295.1 - 3.9e-107 358.6 0.0 4.6e-107 358.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Abhydrolase_1 PF00561.20 ORX51296.1 - 3e-07 30.4 0.0 0.014 15.0 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX51296.1 - 5.8e-05 22.5 0.0 0.0085 15.4 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DRMBL PF07522.14 ORX51297.1 - 4.3e-05 23.7 0.0 0.0012 19.0 0.0 2.3 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ORX51297.1 - 0.00053 19.6 1.4 0.0015 18.1 1.4 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX51297.1 - 2.4 8.1 6.3 7.3 6.5 6.3 1.8 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily OrfB_Zn_ribbon PF07282.11 ORX51298.1 - 3.6e-09 36.4 0.2 1.1e-08 34.9 0.2 1.8 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX51298.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease EcoRII, N-terminal SDA1 PF05285.12 ORX51298.1 - 0.93 8.9 7.1 1.3 8.3 7.1 1.2 1 0 0 1 1 1 0 SDA1 Hexapep PF00132.24 ORX51299.1 - 1.3e-10 40.5 19.2 3.2e-06 26.7 5.1 4.2 3 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ORX51299.1 - 0.0023 17.6 16.6 0.28 11.0 1.3 3.4 2 1 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase PCSK9_C3 PF18463.1 ORX51299.1 - 0.049 13.9 0.4 0.094 13.0 0.4 1.5 1 0 0 1 1 1 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain Radical_SAM PF04055.21 ORX51300.1 - 2.5e-29 102.8 0.4 2.2e-28 99.7 0.1 2.4 3 0 0 3 3 3 1 Radical SAM superfamily UPF0004 PF00919.20 ORX51300.1 - 1e-25 89.6 0.0 2.1e-25 88.6 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0004 TRAM PF01938.20 ORX51300.1 - 5.5e-06 26.3 0.0 9.9e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 TRAM domain TRAM_2 PF18693.1 ORX51300.1 - 0.07 13.3 0.0 0.61 10.3 0.0 2.2 1 1 0 1 1 1 0 TRAM domain DSBA PF01323.20 ORX51301.1 - 1.3e-25 90.4 0.2 1.5e-25 90.1 0.2 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ORX51301.1 - 4.2e-06 27.0 0.1 4.8e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_5 PF13743.6 ORX51301.1 - 0.00051 19.8 0.1 0.00071 19.3 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 ORX51301.1 - 0.036 14.1 0.2 0.13 12.4 0.0 2.0 3 0 0 3 3 3 0 Thioredoxin domain Thioredoxin_2 PF13098.6 ORX51301.1 - 0.071 13.6 0.0 0.11 13.0 0.0 1.4 1 1 0 1 1 1 0 Thioredoxin-like domain HhH-GPD PF00730.25 ORX51302.1 - 2.4e-12 47.2 0.0 7.5e-12 45.7 0.0 1.8 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein LHH PF14411.6 ORX51303.1 - 0.18 12.0 3.1 0.76 10.0 3.1 1.9 1 1 0 1 1 1 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH Med23 PF11573.8 ORX51305.1 - 1.5e-61 208.5 17.1 4e-53 180.6 5.0 2.7 2 1 1 3 3 3 2 Mediator complex subunit 23 Nkap_C PF06047.11 ORX51306.1 - 9.7e-47 157.3 2.8 9.7e-47 157.3 2.8 2.1 2 0 0 2 2 2 1 NF-kappa-B-activating protein C-terminal domain Glycos_transf_4 PF00953.21 ORX51307.1 - 6.7e-32 110.7 15.0 6.7e-32 110.7 15.0 2.6 3 0 0 3 3 3 1 Glycosyl transferase family 4 Actin PF00022.19 ORX51308.1 - 4.3e-148 493.3 0.0 4.9e-148 493.1 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ORX51308.1 - 1.1e-06 27.7 0.0 9.9e-05 21.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein ER_lumen_recept PF00810.18 ORX51309.1 - 7.6e-55 185.8 11.0 1.3e-54 185.0 11.0 1.4 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 ORX51309.1 - 0.011 15.5 10.0 0.3 10.9 0.7 3.5 3 1 1 4 4 4 0 PQ loop repeat GCIP PF13324.6 ORX51310.1 - 4.7e-19 69.0 0.6 4.7e-19 69.0 0.6 1.5 2 0 0 2 2 2 1 Grap2 and cyclin-D-interacting DUF2040 PF09745.9 ORX51311.1 - 1.1e-35 122.3 20.9 1.1e-35 122.3 20.9 4.1 3 2 1 4 4 4 2 Coiled-coil domain-containing protein 55 (DUF2040) Sugar_tr PF00083.24 ORX51312.1 - 1.4e-49 169.2 18.6 1.9e-49 168.8 18.6 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX51312.1 - 4.1e-26 91.7 20.8 4.1e-26 91.7 20.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX51312.1 - 0.016 13.5 12.2 0.033 12.5 9.5 2.5 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family GH-E PF14410.6 ORX51312.1 - 0.24 11.8 0.0 0.47 10.9 0.0 1.3 1 0 0 1 1 1 0 HNH/ENDO VII superfamily nuclease with conserved GHE residues RabGAP-TBC PF00566.18 ORX51314.1 - 4.1e-29 101.8 7.7 8.4e-28 97.5 7.7 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ribosomal_L5e PF17144.4 ORX51315.1 - 1.8e-85 284.9 0.1 3e-85 284.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ORX51315.1 - 1.1e-30 106.4 4.4 1.1e-30 106.4 4.4 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Sorting_nexin PF03700.13 ORX51315.1 - 0.063 13.8 0.0 0.1 13.1 0.0 1.3 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain Peptidase_M3 PF01432.20 ORX51316.1 - 8.8e-125 417.5 0.0 1.2e-124 417.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 EF-hand_4 PF12763.7 ORX51317.1 - 6e-20 71.1 0.2 2.7e-19 69.1 0.0 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ORX51317.1 - 6.3e-06 25.4 0.0 0.016 14.7 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ORX51317.1 - 0.00027 21.3 0.2 0.0013 19.2 0.0 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX51317.1 - 0.0011 18.7 0.0 0.38 10.8 0.0 2.8 2 0 0 2 2 2 1 EF-hand domain Phasin PF05597.11 ORX51317.1 - 0.029 14.4 4.7 0.08 13.0 0.2 2.9 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF5595 PF18077.1 ORX51317.1 - 0.032 14.3 0.7 0.032 14.3 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) E3_binding PF02817.17 ORX51317.1 - 0.045 14.1 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 e3 binding domain Cytochrom_B562 PF07361.11 ORX51317.1 - 0.065 13.9 7.3 0.47 11.1 0.1 3.5 3 0 0 3 3 3 0 Cytochrome b562 DUF5624 PF18538.1 ORX51317.1 - 0.18 11.9 0.4 1 9.5 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) DUF2730 PF10805.8 ORX51317.1 - 0.69 10.0 5.3 0.14 12.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) FUSC PF04632.12 ORX51317.1 - 3.7 6.0 7.3 0.34 9.4 2.1 1.8 2 0 0 2 2 2 0 Fusaric acid resistance protein family Ribosomal_L29 PF00831.23 ORX51317.1 - 4.3 7.4 11.5 30 4.7 1.0 4.2 4 0 0 4 4 4 0 Ribosomal L29 protein Apolipoprotein PF01442.18 ORX51317.1 - 5.1 6.9 22.7 2.3e+02 1.5 20.7 3.2 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1192 PF06698.11 ORX51317.1 - 6.1 7.0 8.5 3.1 7.9 3.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) RhoGEF PF00621.20 ORX51318.1 - 1.2e-21 77.8 2.2 2.7e-21 76.6 2.2 1.6 1 1 0 1 1 1 1 RhoGEF domain TPR_1 PF00515.28 ORX51319.1 - 1.5e-24 84.7 0.0 3.4e-12 45.6 0.0 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX51319.1 - 5.7e-23 79.1 0.0 1.7e-09 37.0 0.0 4.2 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51319.1 - 4.2e-22 78.2 0.4 1.2e-08 35.1 0.0 4.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX51319.1 - 1.2e-19 70.5 1.5 1.4e-07 31.9 0.0 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX51319.1 - 1.6e-19 69.3 0.0 7.3e-10 38.4 0.0 3.4 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 ORX51319.1 - 5.5e-19 66.7 0.0 8.9e-09 34.9 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX51319.1 - 4.5e-13 49.2 0.2 3.1e-06 27.3 0.1 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ORX51319.1 - 1.3e-12 47.1 0.2 5.1e-05 23.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX51319.1 - 5.8e-12 45.4 0.0 0.0048 17.6 0.0 4.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 ORX51319.1 - 3.7e-11 42.9 0.0 9.1e-05 22.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX51319.1 - 3.1e-09 36.2 0.0 0.00014 21.7 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX51319.1 - 4.8e-09 36.7 0.0 0.00068 20.2 0.0 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ORX51319.1 - 3.7e-08 33.0 0.7 0.15 12.0 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX51319.1 - 1.4e-07 31.5 0.0 0.00059 19.9 0.0 2.8 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_20 PF14561.6 ORX51319.1 - 2.4e-06 27.8 1.2 0.067 13.5 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat Paf67 PF10255.9 ORX51319.1 - 0.0005 19.2 0.2 0.0092 15.0 0.4 1.8 1 1 1 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_15 PF13429.6 ORX51319.1 - 0.0012 18.1 0.0 0.006 15.8 0.0 2.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_21 PF09976.9 ORX51319.1 - 0.0028 17.4 0.2 0.057 13.1 0.2 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 ORX51319.1 - 0.0052 16.8 0.0 0.025 14.6 0.0 1.9 1 1 1 2 2 2 1 Putative TPR-like repeat SNAP PF14938.6 ORX51319.1 - 0.0065 15.9 1.2 0.22 10.9 0.1 2.1 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP BTAD PF03704.17 ORX51319.1 - 0.021 15.2 0.1 2 8.8 0.1 2.3 1 1 1 2 2 2 0 Bacterial transcriptional activator domain TOM20_plant PF06552.12 ORX51319.1 - 0.032 14.0 0.4 0.64 9.7 0.1 2.5 1 1 3 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 NARP1 PF12569.8 ORX51319.1 - 0.035 13.0 0.1 0.56 9.0 0.0 1.9 1 1 1 2 2 2 0 NMDA receptor-regulated protein 1 Wzy_C_2 PF11846.8 ORX51319.1 - 0.049 13.6 0.1 0.35 10.8 0.0 1.9 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal RPW8 PF05659.11 ORX51319.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TPR_4 PF07721.14 ORX51319.1 - 0.17 12.6 0.0 0.46 11.3 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Sec15 PF04091.12 ORX51320.1 - 3.5e-18 66.1 0.0 4.3e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Rrn6 PF10214.9 ORX51320.1 - 0.066 11.7 0.0 0.075 11.5 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Sec15 PF04091.12 ORX51321.1 - 1.6e-72 244.6 3.0 3.4e-72 243.5 3.0 1.5 1 0 0 1 1 1 1 Exocyst complex subunit Sec15-like Vps51 PF08700.11 ORX51321.1 - 0.012 15.7 0.2 0.062 13.4 0.2 2.4 1 0 0 1 1 1 0 Vps51/Vps67 Curto_V2 PF07325.11 ORX51321.1 - 0.027 14.3 1.1 0.095 12.6 1.1 1.9 1 0 0 1 1 1 0 Curtovirus V2 protein COG5 PF10392.9 ORX51321.1 - 0.18 12.0 2.8 0.23 11.6 1.1 2.1 2 0 0 2 2 2 0 Golgi transport complex subunit 5 COG2 PF06148.11 ORX51321.1 - 0.29 11.2 9.7 1.8 8.6 4.5 3.4 4 0 0 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 Eno-Rase_FAD_bd PF07055.12 ORX51321.1 - 0.33 11.4 1.7 22 5.5 0.0 4.2 3 1 1 4 4 4 0 Enoyl reductase FAD binding domain RhoGAP PF00620.27 ORX51322.1 - 3.5e-41 140.5 0.0 9.5e-41 139.1 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ORX51322.1 - 9.5e-13 48.6 0.0 2.2e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 PH domain PX PF00787.24 ORX51322.1 - 7.6e-06 25.9 0.0 1.9e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 PX domain PH_11 PF15413.6 ORX51322.1 - 8.9e-05 22.9 0.0 0.00026 21.4 0.0 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain KELK PF15796.5 ORX51322.1 - 0.14 12.7 2.9 0.37 11.3 2.9 1.7 1 0 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ZapB PF06005.12 ORX51322.1 - 0.3 11.6 9.5 0.063 13.7 5.7 1.8 2 0 0 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 ORX51322.1 - 1.5 8.6 4.6 2 8.2 2.8 2.1 2 0 0 2 2 2 0 Septum formation initiator Acyltransferase PF01553.21 ORX51323.1 - 3.3e-21 75.3 0.0 7e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase HTH_Crp_2 PF13545.6 ORX51323.1 - 0.098 12.6 0.0 0.38 10.8 0.0 2.0 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain FAM92 PF06730.11 ORX51324.1 - 0.16 11.4 0.0 0.26 10.7 0.0 1.2 1 0 0 1 1 1 0 FAM92 protein Ribosomal_L28e PF01778.17 ORX51325.1 - 1.2e-29 103.3 1.8 1.5e-29 103.1 1.8 1.1 1 0 0 1 1 1 1 Ribosomal L28e protein family CoA_binding PF02629.19 ORX51325.1 - 0.024 15.3 0.1 0.033 14.9 0.1 1.2 1 0 0 1 1 1 0 CoA binding domain Med3 PF11593.8 ORX51325.1 - 0.98 8.5 8.0 1.2 8.2 8.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pan3_PK PF18101.1 ORX51326.1 - 2.4e-66 221.9 0.0 3.7e-66 221.3 0.0 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 ORX51326.1 - 1.7e-08 34.2 0.0 2.9e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ORX51327.1 - 1.8e-57 194.7 0.0 2.5e-57 194.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51327.1 - 8.2e-43 146.5 0.0 1.2e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX51327.1 - 2.2e-20 72.7 1.1 3.2e-09 37.0 0.1 2.8 2 0 0 2 2 2 2 P21-Rho-binding domain Pkinase_fungal PF17667.1 ORX51327.1 - 1.8e-05 23.7 0.0 2.9e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX51327.1 - 0.0012 18.3 0.1 0.0018 17.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX51327.1 - 0.0019 17.6 0.0 0.0068 15.7 0.0 1.7 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX51327.1 - 0.077 12.9 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family SWIRM PF04433.17 ORX51328.1 - 2.9e-25 88.4 1.0 6.5e-25 87.3 0.1 2.1 2 0 0 2 2 2 1 SWIRM domain SWIRM-assoc_2 PF16496.5 ORX51328.1 - 9.2e-17 61.0 1.9 5.3e-16 58.5 1.9 1.9 1 1 0 1 1 1 1 SWIRM-associated domain at the N-terminal Chromo PF00385.24 ORX51328.1 - 0.00039 20.3 1.3 0.0046 16.8 0.0 2.5 1 1 1 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Myb_DNA-binding PF00249.31 ORX51328.1 - 0.00097 19.3 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX51328.1 - 0.12 12.6 0.0 0.31 11.3 0.0 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 ORX51328.1 - 0.58 10.1 4.9 2.6 8.1 3.8 2.2 2 0 0 2 2 2 0 SWIRM-associated region 1 Ribosomal_S5_C PF03719.15 ORX51329.1 - 8.4e-28 95.6 0.0 6.9e-27 92.7 0.0 2.1 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 ORX51329.1 - 3.7e-22 78.1 1.9 3.7e-22 78.1 1.9 1.6 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain FDX-ACB PF03147.14 ORX51329.1 - 0.078 13.4 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain Fer4 PF00037.27 ORX51330.1 - 3.2e-14 52.0 17.5 1.4e-08 34.2 4.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 ORX51330.1 - 5.3e-13 49.3 10.4 8.1e-13 48.7 10.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ORX51330.1 - 3.3e-10 40.8 7.1 6.9e-05 23.7 0.3 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 ORX51330.1 - 7.8e-10 38.7 4.7 0.00016 21.7 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 ORX51330.1 - 7.5e-09 35.6 10.2 1.2e-08 35.0 10.2 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ORX51330.1 - 7.6e-09 35.6 21.5 3.8e-06 26.9 12.9 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ORX51330.1 - 2.6e-07 30.4 17.8 0.00031 20.7 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 ORX51330.1 - 4.3e-07 30.3 19.1 0.00031 21.1 11.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 ORX51330.1 - 8.9e-07 28.6 12.1 0.0021 18.0 2.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 ORX51330.1 - 5.5e-06 26.5 11.4 0.00027 21.2 2.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 ORX51330.1 - 0.00027 21.4 9.9 0.071 13.7 0.3 2.4 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_17 PF13534.6 ORX51330.1 - 0.00028 21.4 11.4 0.037 14.6 12.7 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_18 PF13746.6 ORX51330.1 - 0.0091 16.2 8.0 0.61 10.3 0.8 2.2 1 1 1 2 2 2 1 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 ORX51330.1 - 0.0092 16.2 5.7 0.34 11.2 0.3 2.3 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_3 PF12798.7 ORX51330.1 - 0.14 13.2 16.3 0.27 12.2 4.1 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_QO PF05187.13 ORX51330.1 - 0.28 11.4 6.7 1.6 8.9 0.8 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_22 PF17179.4 ORX51330.1 - 0.58 11.0 11.8 2.2 9.2 1.9 2.3 1 1 1 2 2 2 0 4Fe-4S dicluster domain EMP70 PF02990.16 ORX51331.1 - 2e-151 505.2 6.7 2.5e-151 504.9 6.7 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 EVC2_like PF12297.8 ORX51331.1 - 0.26 9.9 2.1 21 3.6 0.0 2.3 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein 2OG-FeII_Oxy_2 PF13532.6 ORX51332.1 - 5.7e-37 127.8 0.0 4e-36 125.0 0.0 2.1 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily Peptidase_S8 PF00082.22 ORX51333.1 - 3.5e-38 131.6 0.2 3.5e-38 131.6 0.2 1.6 2 0 0 2 2 2 1 Subtilase family P_proprotein PF01483.20 ORX51333.1 - 9.5e-24 83.2 0.3 2e-23 82.2 0.3 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 ORX51333.1 - 0.019 15.7 5.6 0.17 12.7 5.6 2.3 1 1 0 1 1 1 0 Peptidase S8 pro-domain Plasmodium_Vir PF05795.11 ORX51333.1 - 0.27 10.6 1.0 0.52 9.7 1.0 1.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein SOG2 PF10428.9 ORX51333.1 - 0.73 9.0 14.1 1.1 8.4 14.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Ashwin PF15323.6 ORX51333.1 - 1.2 9.1 8.1 2.2 8.3 8.1 1.3 1 0 0 1 1 1 0 Developmental protein SR-25 PF10500.9 ORX51333.1 - 4 7.0 16.9 7.3 6.1 16.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UCR_14kD PF02271.16 ORX51334.1 - 1.8e-37 127.3 0.2 2.1e-37 127.1 0.2 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit LRR_4 PF12799.7 ORX51335.1 - 0.022 15.2 7.0 0.64 10.5 0.2 4.5 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) DIM1 PF02966.16 ORX51336.1 - 2.7e-66 221.4 0.2 3e-66 221.2 0.2 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin PF00085.20 ORX51336.1 - 1.7e-05 24.8 0.0 2.1e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ORX51336.1 - 0.079 13.3 0.3 0.13 12.6 0.3 1.5 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_7 PF13899.6 ORX51336.1 - 0.14 12.3 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like RasGEF PF00617.19 ORX51337.1 - 1.6e-24 87.1 0.0 3.1e-24 86.1 0.0 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX51337.1 - 8.9e-12 45.2 0.3 2.6e-11 43.7 0.3 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif TPT PF03151.16 ORX51338.1 - 2.3e-47 161.8 23.9 2.6e-47 161.6 23.9 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ORX51338.1 - 2.7e-12 46.5 21.9 3.4e-12 46.2 21.9 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX51338.1 - 8.1e-12 45.5 28.7 9.7e-07 29.0 11.4 2.2 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX51338.1 - 0.00087 18.5 3.0 0.00087 18.5 3.0 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter UcrQ PF02939.16 ORX51339.1 - 9.3e-31 105.6 0.3 1e-30 105.4 0.3 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 ORX51339.1 - 0.0063 16.9 0.0 0.0077 16.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 BAR PF03114.18 ORX51340.1 - 7.3e-31 107.6 7.3 8.7e-31 107.4 7.3 1.1 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 ORX51340.1 - 1.7e-11 43.8 0.1 3.2e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX51340.1 - 5.1e-11 42.0 0.1 1.1e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX51340.1 - 3e-06 26.8 0.1 6.3e-06 25.8 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Lipoprot_C PF08794.10 ORX51340.1 - 0.043 13.8 0.0 5.4 7.0 0.0 2.3 1 1 1 2 2 2 0 Lipoprotein GNA1870 C terminal like Syntaxin_2 PF14523.6 ORX51340.1 - 1.2 9.5 6.6 1.9 8.9 0.4 2.7 3 0 0 3 3 3 0 Syntaxin-like protein 2-Hacid_dh_C PF02826.19 ORX51341.1 - 7e-58 194.9 0.0 9.2e-58 194.5 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX51341.1 - 1.4e-12 47.4 0.0 2.4e-12 46.7 0.0 1.4 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ORX51341.1 - 0.0007 19.8 0.1 0.0012 19.1 0.1 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ORX51341.1 - 0.00076 20.0 0.0 0.0014 19.2 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 ORX51341.1 - 0.077 12.6 0.0 0.16 11.6 0.0 1.6 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 ORX51341.1 - 0.1 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NB-ARC PF00931.22 ORX51341.1 - 0.11 11.7 0.2 0.19 10.9 0.2 1.3 1 0 0 1 1 1 0 NB-ARC domain Pkinase PF00069.25 ORX51342.1 - 1.8e-11 43.9 0.0 2.7e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51342.1 - 0.011 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase CTC1_2 PF15491.6 ORX51342.1 - 0.031 13.6 0.2 0.042 13.2 0.2 1.2 1 0 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 Kinase-like PF14531.6 ORX51342.1 - 0.054 12.8 0.0 0.082 12.2 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CTP_transf_like PF01467.26 ORX51343.1 - 3.3e-29 101.9 0.1 6.2e-29 101.0 0.1 1.5 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF5499 PF17603.2 ORX51343.1 - 0.023 15.3 0.1 0.095 13.3 0.1 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5499) DUF3395 PF11875.8 ORX51344.1 - 9.8e-43 145.7 0.9 9.8e-43 145.7 0.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) DnaJ PF00226.31 ORX51344.1 - 1.5e-20 73.1 1.1 1.5e-20 73.1 1.1 1.8 2 0 0 2 2 2 1 DnaJ domain DUF3246 PF11596.8 ORX51344.1 - 0.22 10.9 0.9 0.42 10.0 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Chitin_synth_2 PF03142.15 ORX51345.1 - 2.8e-237 788.5 2.3 2.8e-237 788.5 2.3 1.4 2 0 0 2 2 2 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX51345.1 - 2.6e-12 47.2 0.0 5.5e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX51345.1 - 6.3e-11 42.6 4.2 1.5e-10 41.3 4.2 1.7 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX51345.1 - 3.7e-06 26.5 0.3 8.7e-05 22.1 0.1 2.2 2 0 0 2 2 2 1 Glycosyl transferase family 21 Eapp_C PF10238.9 ORX51346.1 - 5.6e-39 133.6 17.6 2.5e-29 102.3 4.8 2.4 2 1 1 3 3 3 2 E2F-associated phosphoprotein Yippee-Mis18 PF03226.14 ORX51346.1 - 0.03 14.6 4.1 0.05 13.8 4.1 1.3 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly BAR PF03114.18 ORX51347.1 - 1.1e-21 77.6 2.5 1.6e-21 77.1 2.5 1.2 1 0 0 1 1 1 1 BAR domain SH3_9 PF14604.6 ORX51347.1 - 1.1e-14 54.0 0.0 1.9e-14 53.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX51347.1 - 1.2e-14 53.6 0.1 2.4e-14 52.7 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX51347.1 - 1.9e-10 40.3 0.0 3.4e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Pex14_N PF04695.13 ORX51347.1 - 4.5 7.9 16.3 1.3 9.7 12.8 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.25 ORX51348.1 - 4.9e-48 163.8 0.0 7.3e-48 163.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51348.1 - 2.3e-35 122.1 0.0 3.1e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX51348.1 - 4.7e-05 22.4 0.0 6.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX51348.1 - 0.0052 16.1 0.0 0.0089 15.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Chitin_synth_2 PF03142.15 ORX51349.1 - 2e-273 907.8 0.2 2.5e-273 907.5 0.2 1.0 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX51349.1 - 9.4e-15 55.1 0.0 7.6e-12 45.6 0.0 2.5 1 1 1 2 2 2 2 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX51349.1 - 2.7e-11 43.7 4.0 7e-11 42.4 4.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX51349.1 - 0.0019 18.0 0.1 0.11 12.3 0.0 2.7 3 0 0 3 3 3 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX51349.1 - 0.023 14.2 0.1 0.38 10.2 0.0 2.1 2 0 0 2 2 2 0 Glycosyl transferase family 21 MutS_V PF00488.21 ORX51535.1 - 3.3e-32 112.1 0.0 9.2e-31 107.3 0.0 2.4 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ORX51535.1 - 1.5e-23 84.1 0.8 1.5e-23 84.1 0.8 1.6 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 ORX51535.1 - 2.6e-09 37.3 0.0 5.8e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA PF00004.29 ORX51535.1 - 0.0031 17.9 0.1 0.028 14.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX51535.1 - 0.0035 17.4 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ORX51535.1 - 0.018 15.0 0.1 0.9 9.4 0.0 2.7 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea MutS_II PF05188.17 ORX51535.1 - 0.049 13.9 0.3 0.22 11.8 0.1 2.1 2 0 0 2 2 2 0 MutS domain II G-alpha PF00503.20 ORX51535.1 - 0.055 12.6 0.2 0.15 11.2 0.0 1.8 2 0 0 2 2 2 0 G-protein alpha subunit AAA_30 PF13604.6 ORX51535.1 - 0.067 12.9 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 ORX51535.1 - 0.16 11.5 0.0 0.39 10.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Ion_trans PF00520.31 ORX51536.1 - 1.5e-05 24.3 0.9 1.7e-05 24.2 0.9 1.1 1 0 0 1 1 1 1 Ion transport protein NuDC PF16273.5 ORX51536.1 - 0.0061 17.0 2.1 0.0097 16.4 2.1 1.2 1 0 0 1 1 1 1 Nuclear distribution C domain UPF0242 PF06785.11 ORX51536.1 - 0.014 15.5 7.3 0.038 14.1 7.3 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TSC22 PF01166.18 ORX51536.1 - 0.017 15.4 2.6 0.053 13.8 1.0 2.5 2 1 0 2 2 2 0 TSC-22/dip/bun family CLZ PF16526.5 ORX51536.1 - 0.024 15.0 1.7 0.059 13.7 1.0 1.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DivIC PF04977.15 ORX51536.1 - 0.027 14.2 5.4 0.06 13.1 3.9 2.3 2 1 1 3 3 3 0 Septum formation initiator ZapB PF06005.12 ORX51536.1 - 0.051 14.0 4.1 0.051 14.0 4.1 1.5 2 0 0 2 2 2 0 Cell division protein ZapB FANCI_S1-cap PF14674.6 ORX51536.1 - 0.067 13.3 0.7 0.14 12.3 0.7 1.5 1 0 0 1 1 1 0 FANCI solenoid 1 cap DUF4806 PF16064.5 ORX51536.1 - 0.18 12.2 0.5 0.3 11.4 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) bZIP_1 PF00170.21 ORX51536.1 - 0.2 11.8 5.8 0.39 10.8 3.5 2.0 2 0 0 2 2 2 0 bZIP transcription factor GrpE PF01025.19 ORX51536.1 - 0.23 11.1 1.6 0.33 10.6 1.6 1.2 1 0 0 1 1 1 0 GrpE tRNA-synt_1 PF00133.22 ORX51537.1 - 4.1e-155 517.4 0.0 1.9e-154 515.2 0.0 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX51537.1 - 3.6e-26 91.9 0.9 6.8e-26 91.1 0.9 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX51537.1 - 7.1e-16 57.9 4.2 9.4e-10 37.8 0.0 4.3 5 0 0 5 5 5 3 tRNA synthetases class I (M) zf-FPG_IleRS PF06827.14 ORX51537.1 - 0.004 17.0 2.6 0.004 17.0 2.6 2.1 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS tRNA-synt_1e PF01406.19 ORX51537.1 - 0.034 13.5 0.0 2.2 7.6 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain GRAB PF10375.9 ORX51542.1 - 2.1e-07 30.5 0.4 3.8e-07 29.7 0.4 1.4 1 0 0 1 1 1 1 GRIP-related Arf-binding domain DUF4763 PF15960.5 ORX51542.1 - 0.043 13.1 24.2 0.61 9.4 24.2 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) GRIP PF01465.20 ORX51542.1 - 0.066 13.1 0.1 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 GRIP domain DUF1664 PF07889.12 ORX51542.1 - 0.1 12.7 17.8 1.3 9.1 5.4 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) THP2 PF09432.10 ORX51542.1 - 1 9.4 12.8 2.3 8.3 0.7 3.3 1 1 2 3 3 3 0 Tho complex subunit THP2 Filament PF00038.21 ORX51542.1 - 1.1 8.8 30.8 1.8 8.0 30.8 1.3 1 0 0 1 1 1 0 Intermediate filament protein Fib_alpha PF08702.10 ORX51542.1 - 2.1 8.5 18.4 4.2 7.6 2.7 2.6 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Bacillus_HBL PF05791.11 ORX51542.1 - 2.7 7.8 14.6 0.99 9.2 1.5 3.1 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) ATG16 PF08614.11 ORX51542.1 - 4.7 7.4 34.8 13 6.0 11.7 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BST2 PF16716.5 ORX51542.1 - 5 7.8 28.3 0.093 13.3 6.5 3.9 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 NPV_P10 PF05531.12 ORX51542.1 - 8 7.0 9.7 1.4e+02 3.1 9.4 2.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 ORX51542.1 - 9.6 6.3 36.1 0.53 10.4 15.7 3.6 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein BTB_2 PF02214.22 ORX51543.1 - 1.6e-20 73.2 0.0 4.7e-20 71.7 0.0 1.8 1 0 0 1 1 1 1 BTB/POZ domain DUF1043 PF06295.12 ORX51543.1 - 0.026 14.5 6.9 0.063 13.3 6.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) BTB_3 PF16017.5 ORX51543.1 - 0.067 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain ING PF12998.7 ORX51543.1 - 0.19 12.4 5.1 0.38 11.4 5.1 1.4 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding SIP1 PF04938.12 ORX51543.1 - 0.23 11.1 4.2 1.6 8.4 0.2 2.1 1 1 0 2 2 2 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) SPC22 PF04573.12 ORX51544.1 - 2.4e-48 163.8 0.0 2.9e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 Signal peptidase subunit MFS_1 PF07690.16 ORX51545.1 - 5.8e-11 41.9 32.4 3.8e-10 39.2 31.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 ORX51545.1 - 1.7e-09 37.6 1.9 1.7e-09 37.6 1.9 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 Sugar_tr PF00083.24 ORX51545.1 - 2.8e-08 33.0 8.6 6e-08 32.0 8.6 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter SDF PF00375.18 ORX51545.1 - 0.014 14.4 1.8 0.036 13.1 0.0 2.3 2 0 0 2 2 2 0 Sodium:dicarboxylate symporter family DUF883 PF05957.13 ORX51546.1 - 0.036 14.6 7.1 0.18 12.4 3.4 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) LOB PF03195.14 ORX51546.1 - 0.14 12.8 3.2 0.9 10.2 0.3 2.1 2 0 0 2 2 2 0 Lateral organ boundaries (LOB) domain TMF_DNA_bd PF12329.8 ORX51546.1 - 0.14 12.1 18.4 0.91 9.6 0.2 2.7 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_23 PF13476.6 ORX51546.1 - 0.4 11.2 12.6 0.56 10.7 12.6 1.3 1 0 0 1 1 1 0 AAA domain Laminin_II PF06009.12 ORX51546.1 - 0.71 9.9 9.6 2.6 8.1 6.6 2.1 1 1 1 2 2 2 0 Laminin Domain II Fer4_24 PF18109.1 ORX51546.1 - 1.2 9.5 4.6 1.5 9.1 0.7 2.4 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain DUF4200 PF13863.6 ORX51546.1 - 3 8.3 18.9 0.72 10.3 14.8 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Snapin_Pallidin PF14712.6 ORX51546.1 - 9.9 6.7 19.3 5 7.6 12.2 3.0 2 1 0 2 2 2 0 Snapin/Pallidin K_channel_TID PF07941.11 ORX51549.1 - 0.13 12.7 0.2 0.13 12.7 0.2 4.0 2 1 2 4 4 4 0 Potassium channel Kv1.4 tandem inactivation domain TMEM208_SND2 PF05620.11 ORX51549.1 - 0.29 10.9 1.2 0.99 9.2 0.1 2.1 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Totivirus_coat PF05518.11 ORX51549.1 - 0.36 8.8 18.9 0.44 8.5 18.9 1.1 1 0 0 1 1 1 0 Totivirus coat protein Psm4 PF17063.5 ORX51551.1 - 0.09 13.3 1.6 0.096 13.3 0.1 1.8 2 0 0 2 2 2 0 Phenol-soluble modulin alpha 4 peptide zf-C2H2_4 PF13894.6 ORX51552.1 - 7.7e-06 26.3 9.7 0.00083 20.0 1.5 2.8 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX51552.1 - 1.4e-05 25.2 7.9 0.00079 19.7 2.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ORX51552.1 - 8.5e-05 22.7 6.1 0.045 14.1 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX51552.1 - 0.0019 18.1 1.5 0.0019 18.1 1.5 1.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX51552.1 - 0.0053 17.1 4.5 0.2 12.0 0.3 2.3 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ORX51552.1 - 0.0076 16.6 3.0 0.099 13.1 0.5 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type Zf_RING PF16744.5 ORX51552.1 - 0.018 15.1 0.2 0.07 13.2 0.2 2.1 1 1 0 1 1 1 0 KIAA1045 RING finger zf-Di19 PF05605.12 ORX51552.1 - 0.025 14.9 3.1 0.18 12.1 0.3 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 ORX51552.1 - 0.031 13.9 0.3 3.3 7.4 0.0 2.7 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_12 PF18658.1 ORX51552.1 - 0.18 11.4 0.7 2.1 8.0 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger C2H2-type FYVE PF01363.21 ORX51552.1 - 0.18 11.9 6.7 1.2 9.4 0.6 2.5 2 0 0 2 2 2 0 FYVE zinc finger DEAD PF00270.29 ORX51553.1 - 2.2e-47 161.1 0.0 4.7e-47 160.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX51553.1 - 5e-31 107.3 0.0 1.6e-27 96.0 0.0 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain GUCT PF08152.12 ORX51553.1 - 7.5e-22 77.4 0.0 1.8e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 GUCT (NUC152) domain ResIII PF04851.15 ORX51553.1 - 3.3e-07 30.5 0.0 6.2e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ORX51553.1 - 0.0012 18.3 0.0 0.0012 18.3 0.0 1.9 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit DUF4915 PF16261.5 ORX51553.1 - 0.0037 16.6 0.2 0.018 14.3 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4915) BicD PF09730.9 ORX51554.1 - 0.0012 17.3 26.1 0.0012 17.3 26.1 2.0 1 1 1 2 2 2 1 Microtubule-associated protein Bicaudal-D MscS_porin PF12795.7 ORX51554.1 - 0.0021 17.6 61.6 0.27 10.7 40.5 2.3 1 1 1 2 2 2 2 Mechanosensitive ion channel porin domain Peptidase_M61 PF05299.12 ORX51554.1 - 0.0061 17.0 2.7 0.0061 17.0 2.7 3.5 1 1 2 4 4 4 1 M61 glycyl aminopeptidase YscO PF07321.12 ORX51554.1 - 0.0063 16.5 9.7 0.0063 16.5 9.7 3.8 2 1 1 3 3 2 1 Type III secretion protein YscO DUF745 PF05335.13 ORX51554.1 - 0.012 15.3 44.4 0.021 14.6 12.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF745) HIP1_clath_bdg PF16515.5 ORX51554.1 - 0.025 15.2 52.4 1.2 9.8 7.3 3.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 ORX51554.1 - 0.059 13.6 55.6 0.35 11.1 13.2 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TMF_DNA_bd PF12329.8 ORX51554.1 - 0.06 13.3 0.5 0.06 13.3 0.5 5.4 2 2 2 5 5 4 0 TATA element modulatory factor 1 DNA binding Laminin_II PF06009.12 ORX51554.1 - 0.12 12.4 30.5 0.19 11.7 4.5 3.8 1 1 3 4 4 4 0 Laminin Domain II Filament PF00038.21 ORX51554.1 - 0.13 11.8 49.4 2.8 7.4 22.5 3.0 1 1 2 3 3 3 0 Intermediate filament protein LXG PF04740.12 ORX51554.1 - 0.14 11.9 41.5 0.054 13.2 17.8 3.0 1 1 1 2 2 2 0 LXG domain of WXG superfamily Lebercilin PF15619.6 ORX51554.1 - 0.2 11.3 53.3 0.44 10.2 10.7 3.1 1 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease EzrA PF06160.12 ORX51554.1 - 0.23 9.6 41.1 0.34 9.0 11.7 3.0 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA KxDL PF10241.9 ORX51554.1 - 0.28 11.5 36.8 3.6 7.9 0.4 5.0 2 1 3 5 5 5 0 Uncharacterized conserved protein Tropomyosin_1 PF12718.7 ORX51554.1 - 0.59 10.3 46.3 0.041 14.0 8.6 3.1 1 1 2 3 3 3 0 Tropomyosin like GAS PF13851.6 ORX51554.1 - 0.64 9.3 50.0 0.56 9.5 6.2 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Leu_zip PF15294.6 ORX51554.1 - 0.71 9.3 39.9 0.79 9.2 19.6 2.5 1 1 1 2 2 2 0 Leucine zipper FAM184 PF15665.5 ORX51554.1 - 0.79 9.5 50.9 0.55 10.0 15.1 2.8 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B MAD PF05557.13 ORX51554.1 - 1.2 7.5 47.6 0.27 9.5 15.6 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein ERM PF00769.19 ORX51554.1 - 1.8 8.3 57.5 0.9 9.3 18.0 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family ADIP PF11559.8 ORX51554.1 - 2.4 8.2 55.7 0.039 14.0 14.3 3.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding T3SSipB PF16535.5 ORX51554.1 - 2.5 8.5 41.0 1.9 8.9 9.9 3.3 1 1 2 3 3 3 0 Type III cell invasion protein SipB Occludin_ELL PF07303.13 ORX51554.1 - 2.8 8.7 37.8 0.7 10.7 6.7 4.2 1 1 3 4 4 4 0 Occludin homology domain TPR_MLP1_2 PF07926.12 ORX51554.1 - 3.2 7.8 59.7 1.7 8.7 27.4 3.4 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 ORX51554.1 - 3.2 7.8 44.1 1.9 8.5 6.0 3.8 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Imm3 PF14425.6 ORX51554.1 - 3.5 7.7 10.2 3.1 7.8 4.9 3.3 2 2 1 3 3 3 0 Immunity protein Imm3 DUF4763 PF15960.5 ORX51554.1 - 3.6 6.8 41.9 0.44 9.8 6.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) DUF3584 PF12128.8 ORX51554.1 - 3.7 5.0 56.2 2.4 5.6 35.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Tropomyosin PF00261.20 ORX51554.1 - 4.2 6.7 41.6 0.03 13.7 9.2 2.4 1 1 1 2 2 2 0 Tropomyosin DUF4407 PF14362.6 ORX51554.1 - 4.4 6.6 47.0 8.1 5.7 25.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Cep57_CLD_2 PF14197.6 ORX51554.1 - 6.5 6.9 42.4 0.19 11.8 2.7 5.0 3 2 2 5 5 5 0 Centrosome localisation domain of PPC89 Snapin_Pallidin PF14712.6 ORX51554.1 - 6.7 7.2 46.1 0.7 10.3 12.2 3.4 2 1 1 3 3 3 0 Snapin/Pallidin COG2 PF06148.11 ORX51554.1 - 7.8 6.6 28.9 7.4 6.7 5.7 4.0 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 ORX51554.1 - 8.9 6.4 33.5 3.4 7.7 8.2 3.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) RINGv PF12906.7 ORX51555.1 - 3.4e-05 23.9 16.1 5.8e-05 23.1 16.1 1.4 1 0 0 1 1 1 1 RING-variant domain FANCL_C PF11793.8 ORX51555.1 - 0.00028 21.0 9.8 0.00058 20.0 9.8 1.5 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 ORX51555.1 - 0.0071 16.7 12.8 0.013 15.8 12.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-Mss51 PF13824.6 ORX51555.1 - 0.35 11.0 5.1 0.13 12.4 2.1 1.8 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-RING_5 PF14634.6 ORX51555.1 - 8.7 6.4 10.3 18 5.4 10.3 1.6 1 0 0 1 1 1 0 zinc-RING finger domain NapE PF06796.11 ORX51557.1 - 0.52 9.9 0.1 0.52 9.9 0.1 2.0 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE Glucosamine_iso PF01182.20 ORX51558.1 - 7.4e-20 71.8 0.0 1.1e-19 71.2 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Fip1 PF05182.13 ORX51559.1 - 2.7e-24 84.4 1.7 6e-24 83.3 1.7 1.6 1 0 0 1 1 1 1 Fip1 motif Peptidase_S64 PF08192.11 ORX51559.1 - 0.12 10.8 2.0 0.18 10.3 2.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 Nop14 PF04147.12 ORX51559.1 - 5.2 5.1 21.4 7.8 4.6 21.4 1.2 1 0 0 1 1 1 0 Nop14-like family FRG PF08867.11 ORX51560.1 - 0.1 13.5 0.1 0.46 11.5 0.1 2.1 1 0 0 1 1 1 0 FRG domain Sugar_tr PF00083.24 ORX51561.1 - 3.5e-75 253.6 15.2 4.2e-75 253.3 15.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX51561.1 - 3.9e-23 81.9 26.5 5.8e-23 81.4 18.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX51561.1 - 0.00014 21.3 5.4 0.00014 21.3 5.4 2.0 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB UNC-93 PF05978.16 ORX51561.1 - 0.044 13.5 6.1 0.24 11.1 3.1 2.8 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 DUF3678 PF12435.8 ORX51563.1 - 0.25 10.7 1.3 0.63 9.5 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3678) PP2C PF00481.21 ORX51564.1 - 8.3e-07 28.9 0.0 9.6e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C GTP1_OBG PF01018.22 ORX51565.1 - 0.0022 17.6 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 GTP1/OBG WD40 PF00400.32 ORX51566.1 - 1.8e-15 57.0 5.7 0.00033 21.4 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat LisH_TPL PF17814.1 ORX51566.1 - 2e-10 40.1 0.9 5e-10 38.9 0.9 1.7 1 0 0 1 1 1 1 LisH-like dimerisation domain ANAPC4_WD40 PF12894.7 ORX51566.1 - 3e-09 37.1 0.6 0.073 13.4 0.0 3.8 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX51566.1 - 0.022 14.1 0.7 2.9 7.1 0.0 2.9 2 1 1 3 3 3 0 WD40-like domain PMSR PF01625.21 ORX51568.1 - 7e-60 201.6 4.5 8.2e-60 201.4 4.5 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF1882 PF08966.11 ORX51568.1 - 0.12 12.6 0.5 3.5 7.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) Glyoxalase PF00903.25 ORX51569.1 - 3e-08 33.9 0.0 6.9e-07 29.5 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ORX51569.1 - 0.012 15.5 0.2 0.13 12.2 0.2 2.2 1 1 0 1 1 1 0 Glyoxalase-like domain Mg_trans_NIPA PF05653.14 ORX51572.1 - 4.2e-99 331.4 18.7 4.9e-99 331.2 18.7 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX51572.1 - 5.2e-08 33.1 32.3 4.4e-05 23.7 4.1 4.3 3 1 1 4 4 4 3 EamA-like transporter family DUF418 PF04235.12 ORX51572.1 - 0.91 9.4 10.3 0.13 12.1 0.3 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF418) DUF3040 PF11239.8 ORX51572.1 - 8 6.8 12.5 5.7 7.3 0.1 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3040) Ras PF00071.22 ORX51573.1 - 2.1e-54 183.5 0.0 2.4e-54 183.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX51573.1 - 1.1e-22 80.5 0.0 1.6e-22 79.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX51573.1 - 4.4e-08 32.8 0.0 5.7e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family BOP1NT PF08145.12 ORX51575.1 - 0.031 14.2 0.4 0.043 13.7 0.4 1.2 1 0 0 1 1 1 0 BOP1NT (NUC169) domain PQ-loop PF04193.14 ORX51581.1 - 0.033 14.0 0.4 0.058 13.2 0.4 1.4 1 0 0 1 1 1 0 PQ loop repeat EamA PF00892.20 ORX51582.1 - 6.5e-11 42.6 41.2 2.2e-06 27.9 9.7 3.1 3 0 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX51582.1 - 0.0013 18.0 20.3 0.0023 17.2 20.3 1.4 1 0 0 1 1 1 1 Nucleotide-sugar transporter TPT PF03151.16 ORX51582.1 - 0.08 12.3 24.5 0.1 11.9 21.4 2.3 2 1 0 2 2 2 0 Triose-phosphate Transporter family PUNUT PF16913.5 ORX51582.1 - 0.13 11.4 34.4 0.2 10.9 29.2 2.7 2 1 0 2 2 2 0 Purine nucleobase transmembrane transport Glyco_hydro_18 PF00704.28 ORX51584.1 - 1.7e-70 238.2 2.5 1.9e-70 238.1 2.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Zn_clus PF00172.18 ORX51585.1 - 3.1e-09 36.8 13.8 4.5e-09 36.3 13.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TLD PF07534.16 ORX51586.1 - 5.8e-16 59.0 0.0 1.1e-15 58.1 0.0 1.5 1 0 0 1 1 1 1 TLD Pkinase PF00069.25 ORX51587.1 - 3.4e-66 223.3 0.0 4e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51587.1 - 2.5e-36 125.3 0.0 3.8e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX51587.1 - 2.5e-05 24.3 0.0 0.00054 20.0 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX51587.1 - 4.1e-05 22.7 0.4 6.9e-05 22.0 0.1 1.4 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ORX51587.1 - 0.005 16.2 0.1 0.008 15.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ORX51587.1 - 0.009 15.6 0.1 0.023 14.3 0.0 1.7 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 ORX51587.1 - 0.011 15.3 0.2 0.023 14.3 0.2 1.5 1 0 0 1 1 1 0 RIO1 family OSR1_C PF12202.8 ORX51588.1 - 0.049 13.9 0.1 0.15 12.3 0.1 1.8 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Med8 PF10232.9 ORX51589.1 - 0.0013 18.3 1.2 0.0031 17.1 1.2 1.6 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Pkinase PF00069.25 ORX51590.1 - 5.4e-61 206.3 0.0 7.4e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51590.1 - 4.1e-32 111.5 0.0 5.8e-32 111.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX51590.1 - 3.8e-05 23.1 0.0 0.00011 21.6 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ORX51590.1 - 6.3e-05 23.0 0.9 0.00029 20.8 0.8 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 ORX51590.1 - 8.9e-05 22.2 0.2 0.056 13.1 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ORX51590.1 - 0.0026 16.6 0.0 0.0039 16.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX51590.1 - 0.035 13.4 0.1 0.073 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ORX51590.1 - 0.085 11.9 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 O-FucT PF10250.9 ORX51591.1 - 2.8e-11 43.7 0.0 1.5e-06 28.2 0.0 3.5 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase CCDC53 PF10152.9 ORX51591.1 - 1.1 9.7 4.8 1.9 8.9 4.8 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TFIIA PF03153.13 ORX51591.1 - 2.1 8.3 8.1 3 7.7 8.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GTP_EFTU PF00009.27 ORX51592.1 - 2.1e-35 122.0 0.0 3.4e-35 121.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX51592.1 - 3.8e-18 65.8 0.1 1.6e-17 63.8 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D4 PF14578.6 ORX51592.1 - 6.3e-05 22.8 1.0 0.00028 20.7 1.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 ORX51592.1 - 0.0018 18.6 0.2 0.0038 17.6 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX51592.1 - 0.003 17.6 0.0 0.0058 16.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ORX51592.1 - 0.029 14.0 0.0 2.4 7.7 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain G_path_suppress PF15991.5 ORX51593.1 - 1.5 8.9 9.9 1.7 8.7 8.5 1.7 1 1 0 1 1 1 0 G-protein pathway suppressor HBS1_N PF08938.10 ORX51594.1 - 7.1e-15 55.1 1.4 9.9e-15 54.6 1.4 1.3 1 1 0 1 1 1 1 HBS1 N-terminus DUF4530 PF15039.6 ORX51596.1 - 0.34 11.0 0.1 0.34 11.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) TPR_2 PF07719.17 ORX51597.1 - 4.1e-11 42.1 13.3 0.00012 21.9 3.4 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX51597.1 - 1.3e-10 41.6 6.1 4.9e-05 23.8 2.6 4.2 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX51597.1 - 5.5e-10 39.2 7.2 0.00072 20.2 0.4 5.1 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX51597.1 - 2e-08 34.7 1.3 0.017 15.7 0.1 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX51597.1 - 6.7e-06 25.7 13.7 0.021 14.6 4.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX51597.1 - 0.00038 20.4 9.1 0.58 10.5 0.9 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX51597.1 - 0.00095 18.8 11.4 0.0014 18.3 0.0 4.5 4 1 1 5 5 5 1 TPR repeat TPR_9 PF13371.6 ORX51597.1 - 0.0024 18.0 1.0 0.0024 18.0 1.0 2.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51597.1 - 0.0038 17.5 7.9 0.56 10.5 3.6 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX51597.1 - 0.028 14.8 0.5 0.028 14.8 0.5 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Urocanase_N PF17391.2 ORX51597.1 - 0.058 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Urocanase N-terminal domain ANAPC3 PF12895.7 ORX51597.1 - 0.11 12.7 8.8 0.22 11.8 7.3 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ORX51597.1 - 0.88 9.7 5.3 0.48 10.5 0.3 3.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat AA_kinase PF00696.28 ORX51598.1 - 7.7e-37 127.2 0.0 9.7e-37 126.8 0.0 1.0 1 0 0 1 1 1 1 Amino acid kinase family Spo7_2_N PF15407.6 ORX51598.1 - 0.099 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein family 7 Acyltransferase PF01553.21 ORX51600.1 - 1.3e-33 115.5 0.0 1.8e-33 115.0 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase FGase PF05013.12 ORX51601.1 - 1.1e-10 42.1 0.0 5e-05 23.6 0.0 3.0 1 1 1 2 2 2 2 N-formylglutamate amidohydrolase Aldo_ket_red PF00248.21 ORX51603.1 - 6.7e-69 232.3 0.0 7.9e-69 232.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF5581 PF17744.1 ORX51603.1 - 0.2 11.0 0.2 12 5.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5581) Oxysterol_BP PF01237.18 ORX51604.1 - 7.4e-75 252.1 0.9 1.4e-72 244.6 0.9 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Ribosomal_S7 PF00177.21 ORX51605.1 - 1e-37 129.1 1.0 1.3e-37 128.7 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e His_Phos_2 PF00328.22 ORX51606.1 - 5.3e-83 279.5 0.0 7.5e-83 279.0 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 ORX51606.1 - 2.2e-34 117.4 0.0 6.3e-34 116.0 0.0 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 ORX51606.1 - 7.9e-06 25.6 0.0 1.5e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain PHD PF00628.29 ORX51607.1 - 1.8e-10 40.6 10.6 3.8e-10 39.5 8.3 2.4 2 0 0 2 2 2 1 PHD-finger SET PF00856.28 ORX51607.1 - 0.0018 18.7 0.0 0.0056 17.1 0.0 1.7 1 1 0 1 1 1 1 SET domain PHD_2 PF13831.6 ORX51607.1 - 0.0025 17.3 1.8 0.0056 16.2 1.8 1.6 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 ORX51607.1 - 0.064 12.9 2.3 0.67 9.5 1.0 2.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain zf-CW PF07496.15 ORX51607.1 - 0.19 11.8 3.2 0.5 10.4 3.2 1.8 1 0 0 1 1 1 0 CW-type Zinc Finger DSPc PF00782.20 ORX51608.1 - 3.9e-10 39.6 0.0 6.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 ORX51608.1 - 2.1e-05 24.2 0.2 4.7e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 ORX51608.1 - 0.001 18.7 0.0 0.0014 18.3 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX51608.1 - 0.0028 17.8 0.0 0.0051 16.9 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF442 PF04273.13 ORX51608.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Putative phosphatase (DUF442) F_actin_cap_B PF01115.17 ORX51609.1 - 1.2e-102 342.6 0.0 1.4e-102 342.4 0.0 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit F-actin_cap_A PF01267.17 ORX51609.1 - 1.6e-05 24.5 0.6 0.00044 19.8 0.2 2.7 1 1 1 2 2 2 2 F-actin capping protein alpha subunit Ribosomal_S21e PF01249.18 ORX51612.1 - 2.3e-39 133.3 0.0 2.6e-39 133.2 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Cullin PF00888.22 ORX51613.1 - 2.8e-55 188.1 11.0 3.6e-55 187.8 11.0 1.1 1 0 0 1 1 1 1 Cullin family Penicillinase_R PF03965.16 ORX51613.1 - 0.00076 19.8 0.1 0.0025 18.1 0.1 1.9 1 0 0 1 1 1 1 Penicillinase repressor Cullin_Nedd8 PF10557.9 ORX51613.1 - 0.0019 18.2 0.0 0.0066 16.5 0.0 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain GAF_2 PF13185.6 ORX51614.1 - 2.1e-10 41.0 0.0 2.7e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 ORX51614.1 - 1.7e-06 28.7 0.0 1.9e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ORX51614.1 - 0.001 19.4 0.0 0.0015 18.9 0.0 1.3 1 0 0 1 1 1 1 GAF domain Ank_4 PF13637.6 ORX51617.1 - 0.00021 21.8 0.1 0.0098 16.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX51617.1 - 0.00026 21.5 0.2 0.00057 20.4 0.2 1.8 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX51617.1 - 0.0073 16.6 0.1 0.019 15.3 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX51617.1 - 0.02 15.4 0.9 0.14 12.8 0.1 2.6 3 0 0 3 3 3 0 Ankyrin repeat Ank PF00023.30 ORX51617.1 - 0.13 12.8 0.5 0.74 10.4 0.2 2.3 2 0 0 2 2 2 0 Ankyrin repeat GIT_SHD PF08518.11 ORX51619.1 - 1e-25 89.0 6.5 6.7e-15 54.4 0.5 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 ORX51619.1 - 3.8e-05 23.8 5.5 0.006 16.7 0.1 3.0 2 1 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term Wtap PF17098.5 ORX51619.1 - 0.0074 16.2 9.4 0.0074 16.2 9.4 3.2 1 1 1 2 2 2 1 WTAP/Mum2p family CENP-F_leu_zip PF10473.9 ORX51619.1 - 0.0075 16.3 11.8 0.0075 16.3 11.8 3.0 3 0 0 3 3 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ORX51619.1 - 0.0083 16.7 14.9 0.0083 16.7 14.9 3.0 3 0 0 3 3 2 1 Apg6 coiled-coil region Focal_AT PF03623.13 ORX51619.1 - 0.0085 16.1 4.7 0.22 11.5 0.0 3.8 3 1 0 3 3 3 1 Focal adhesion targeting region DUF745 PF05335.13 ORX51619.1 - 0.01 15.6 6.4 0.031 14.0 6.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Spc7 PF08317.11 ORX51619.1 - 0.013 14.4 17.1 0.026 13.4 17.1 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein ApoLp-III PF07464.11 ORX51619.1 - 0.017 15.2 2.6 0.017 15.2 2.6 2.8 3 0 0 3 3 2 0 Apolipophorin-III precursor (apoLp-III) JIP_LZII PF16471.5 ORX51619.1 - 0.044 14.0 14.3 0.89 9.8 0.2 3.6 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF724 PF05266.14 ORX51619.1 - 0.048 13.5 19.0 0.14 11.9 17.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HAP1_N PF04849.13 ORX51619.1 - 0.056 12.6 20.6 0.1 11.8 20.6 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Shugoshin_N PF07558.11 ORX51619.1 - 0.085 12.7 3.3 3.6 7.5 0.7 3.0 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region MPS2 PF17060.5 ORX51619.1 - 0.14 11.4 19.2 0.42 9.8 14.5 2.3 1 1 1 2 2 2 0 Monopolar spindle protein 2 TSC22 PF01166.18 ORX51619.1 - 0.19 12.1 9.2 0.072 13.4 0.7 3.5 3 0 0 3 3 2 0 TSC-22/dip/bun family PSII_Pbs27 PF13326.6 ORX51619.1 - 0.29 11.5 5.7 0.061 13.6 1.0 2.3 3 0 0 3 3 1 0 Photosystem II Pbs27 TMF_TATA_bd PF12325.8 ORX51619.1 - 1.5 9.1 25.0 0.036 14.3 9.6 3.6 2 1 1 3 3 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 ORX51619.1 - 1.6 8.9 17.7 2.5 8.2 2.6 4.0 2 1 1 3 3 3 0 bZIP transcription factor V_ATPase_I PF01496.19 ORX51619.1 - 1.9 6.3 10.5 3 5.7 10.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ORX51619.1 - 1.9 7.7 15.4 7.2 5.9 15.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4239 PF14023.6 ORX51619.1 - 2 8.1 6.2 0.75 9.5 1.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) YabA PF06156.13 ORX51619.1 - 2.5 8.8 16.3 2.3 8.9 5.3 3.3 1 1 1 2 2 2 0 Initiation control protein YabA DUF2721 PF11026.8 ORX51619.1 - 2.5 8.0 7.0 6.2 6.7 1.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) Hemagglutinin PF00509.18 ORX51619.1 - 2.7 6.3 4.1 4.4 5.6 4.1 1.2 1 0 0 1 1 1 0 Haemagglutinin ATG16 PF08614.11 ORX51619.1 - 3 8.0 29.4 0.24 11.6 19.2 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 ORX51619.1 - 4.4 7.5 26.9 0.13 12.5 15.2 2.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Bap31_Bap29_C PF18035.1 ORX51619.1 - 5.3 7.1 16.9 0.57 10.2 7.1 2.9 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Nmad5 PF18757.1 ORX51619.1 - 6.1 7.0 10.6 5.5 7.1 8.4 2.0 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 Cep57_CLD_2 PF14197.6 ORX51619.1 - 6.2 7.0 21.4 4.6 7.4 10.7 3.6 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 DUF3450 PF11932.8 ORX51619.1 - 7.6 5.8 19.6 0.25 10.6 9.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) BLOC1_2 PF10046.9 ORX51619.1 - 8.2 6.8 15.7 3.5 8.0 2.4 3.5 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FUSC PF04632.12 ORX51619.1 - 8.3 4.8 12.2 0.61 8.6 6.2 2.1 2 1 0 2 2 2 0 Fusaric acid resistance protein family Tropomyosin_1 PF12718.7 ORX51619.1 - 8.9 6.5 27.5 1.3e+02 2.7 9.7 3.3 1 1 1 2 2 2 0 Tropomyosin like SHE3 PF17078.5 ORX51619.1 - 9 5.9 23.7 0.29 10.8 7.0 2.4 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Fungal_trans_2 PF11951.8 ORX51619.1 - 9.3 4.9 9.8 29 3.3 5.6 2.8 2 1 0 2 2 2 0 Fungal specific transcription factor domain HEAT_2 PF13646.6 ORX51620.1 - 1.1e-35 121.9 2.5 2.1e-14 53.7 0.1 4.1 2 2 2 4 4 4 4 HEAT repeats HEAT_PBS PF03130.16 ORX51620.1 - 1.9e-28 96.2 0.0 0.00042 20.7 0.0 6.6 6 0 0 6 6 6 6 PBS lyase HEAT-like repeat HEAT PF02985.22 ORX51620.1 - 1.1e-13 50.2 0.1 0.036 14.3 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 ORX51620.1 - 9.2e-07 29.3 1.0 0.022 15.3 0.0 5.1 5 2 1 6 6 6 1 HEAT-like repeat Cnd1 PF12717.7 ORX51620.1 - 0.0011 19.0 0.2 1.2 9.2 0.0 3.7 1 1 2 4 4 4 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 ORX51620.1 - 0.0091 16.0 0.0 1.5 9.0 0.0 2.9 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat DUF4122 PF13498.6 ORX51620.1 - 0.076 12.7 0.3 0.47 10.1 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4122) Cohesin_HEAT PF12765.7 ORX51620.1 - 0.11 12.9 0.1 0.6 10.5 0.0 2.2 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Ribosomal_L24e PF01246.20 ORX51622.1 - 2.2e-22 79.0 1.2 2.2e-22 79.0 1.2 2.2 2 2 1 3 3 3 1 Ribosomal protein L24e Glyco_transf_17 PF04724.13 ORX51623.1 - 0.076 12.0 0.1 1.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase family 17 Myb_DNA-binding PF00249.31 ORX51624.1 - 1.1e-10 41.6 0.1 2.8e-10 40.2 0.1 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ORX51624.1 - 1e-08 34.8 7.9 2.3e-08 33.7 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 ORX51624.1 - 1.1e-08 35.3 0.3 3.9e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-bind_6 PF13921.6 ORX51624.1 - 0.00037 20.7 0.1 0.00093 19.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Questin_oxidase PF14027.6 ORX51625.1 - 5.1e-32 111.7 0.2 7.3e-32 111.2 0.2 1.1 1 0 0 1 1 1 1 Questin oxidase-like TPR_7 PF13176.6 ORX51625.1 - 0.1 12.7 0.0 0.25 11.4 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat FRG1 PF06229.12 ORX51626.1 - 1.6e-30 106.3 0.1 1.9e-30 106.0 0.1 1.0 1 0 0 1 1 1 1 FRG1-like domain Tetraspanin PF00335.20 ORX51627.1 - 1.5e-07 31.3 10.8 2.9e-07 30.4 10.8 1.4 1 1 0 1 1 1 1 Tetraspanin family DUF2970 PF11174.8 ORX51627.1 - 4.5 7.2 9.7 0.17 11.8 1.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2970) Mpv17_PMP22 PF04117.12 ORX51628.1 - 4.7e-14 52.4 0.4 8.6e-14 51.5 0.1 1.6 2 0 0 2 2 2 1 Mpv17 / PMP22 family Kinesin PF00225.23 ORX51629.1 - 1.9e-95 319.6 0.0 2.8e-95 319.0 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX51629.1 - 3.5e-16 59.5 0.0 8.8e-16 58.2 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding SAM_1 PF00536.30 ORX51629.1 - 3.2e-07 30.7 0.3 6.9e-07 29.6 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ORX51629.1 - 2.9e-06 27.3 0.3 6.1e-06 26.2 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1780 PF08682.10 ORX51629.1 - 0.046 13.4 0.1 0.13 12.0 0.0 1.7 2 0 0 2 2 2 0 Putative endonuclease, protein of unknown function (DUF1780) CYSTM PF12734.7 ORX51631.1 - 0.003 17.8 8.4 0.036 14.4 8.4 2.2 1 1 0 1 1 1 1 Cysteine-rich TM module stress tolerance Exo_endo_phos PF03372.23 ORX51632.1 - 4.7e-17 62.3 0.1 8.1e-17 61.5 0.1 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 ORX51632.1 - 5.2e-09 36.0 2.0 1.2e-08 34.9 2.0 1.6 1 0 0 1 1 1 1 GRF zinc finger Pkinase PF00069.25 ORX51633.1 - 3.1e-56 190.6 1.4 1.7e-55 188.2 1.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51633.1 - 9e-39 133.3 0.9 1.6e-23 83.3 3.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX51633.1 - 1.5e-08 34.3 0.0 0.0012 18.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX51633.1 - 0.0007 19.2 3.6 0.0019 17.9 3.5 1.6 1 1 1 2 2 2 1 RIO1 family APH PF01636.23 ORX51633.1 - 0.037 14.0 0.9 0.071 13.0 0.7 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX51633.1 - 0.096 12.0 3.0 0.16 11.3 3.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ORX51633.1 - 0.098 11.7 0.4 0.16 11.0 0.4 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ORX51633.1 - 0.14 11.1 15.5 0.79 8.6 15.5 2.2 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX51633.1 - 0.33 9.7 4.5 0.54 9.0 4.5 1.6 1 1 0 1 1 1 0 Fungal protein kinase SR-25 PF10500.9 ORX51633.1 - 5.1 6.6 11.6 9 5.8 11.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein UPF0029 PF01205.19 ORX51634.1 - 5.8e-35 119.8 0.1 1e-34 119.0 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 ORX51634.1 - 8.8e-12 45.3 0.1 1.4e-11 44.7 0.1 1.3 1 0 0 1 1 1 1 RWD domain L31 PF09784.9 ORX51635.1 - 3.5e-38 130.1 0.2 3.9e-38 130.0 0.2 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Nop52 PF05997.12 ORX51636.1 - 2e-52 178.1 0.2 2.4e-52 177.9 0.2 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Pox_vIL-18BP PF05566.12 ORX51636.1 - 0.09 13.0 0.0 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 Orthopoxvirus interleukin 18 binding protein PGA2 PF07543.12 ORX51636.1 - 0.13 12.2 4.1 0.24 11.4 4.1 1.5 1 1 0 1 1 1 0 Protein trafficking PGA2 Erv26 PF04148.13 ORX51637.1 - 5e-61 206.1 17.6 2.3e-60 204.0 17.6 1.9 1 1 0 1 1 1 1 Transmembrane adaptor Erv26 DUF2909 PF11137.8 ORX51637.1 - 0.074 13.0 0.6 0.16 11.9 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2909) NST1 PF13945.6 ORX51639.1 - 3.7e-52 177.2 2.6 5e-52 176.8 2.6 1.1 1 0 0 1 1 1 1 Salt tolerance down-regulator FeoB_associated PF12669.7 ORX51639.1 - 0.31 11.5 2.7 0.72 10.3 2.7 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Bmp PF02608.14 ORX51643.1 - 0.036 13.0 0.2 0.044 12.8 0.2 1.1 1 0 0 1 1 1 0 ABC transporter substrate-binding protein PnrA-like GD_N PF16030.5 ORX51643.1 - 0.081 13.2 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Serine protease gd N-terminus HTH_23 PF13384.6 ORX51645.1 - 6.5e-06 25.8 0.0 1.1e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain Myb_DNA-bind_6 PF13921.6 ORX51645.1 - 0.0012 19.0 0.5 0.0039 17.4 0.5 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 ORX51645.1 - 0.024 14.9 0.1 0.078 13.3 0.1 1.8 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Rap1_C PF11626.8 ORX51645.1 - 0.047 13.8 0.1 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Agenet PF05641.12 ORX51645.1 - 0.071 13.6 0.2 0.14 12.7 0.2 1.5 1 0 0 1 1 1 0 Agenet domain HTH_29 PF13551.6 ORX51645.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix Mpv17_PMP22 PF04117.12 ORX51646.1 - 3.7e-09 36.7 0.6 7.4e-09 35.7 0.3 1.7 2 0 0 2 2 2 1 Mpv17 / PMP22 family DUF3023 PF11224.8 ORX51646.1 - 0.0044 16.9 0.0 0.0061 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3023) Methyltransf_34 PF11312.8 ORX51647.1 - 5.8e-21 75.0 0.2 1.3e-20 73.9 0.2 1.5 1 1 0 1 1 1 1 Putative SAM-dependent methyltransferase Pro_dh-DNA_bdg PF14850.6 ORX51647.1 - 0.057 14.0 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 DNA-binding domain of Proline dehydrogenase AMP-binding PF00501.28 ORX51649.1 - 3.9e-100 335.4 0.0 5e-100 335.1 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme RRM_1 PF00076.22 ORX51651.1 - 3.2e-10 39.7 0.1 6.9e-10 38.6 0.1 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX51651.1 - 8.4e-05 22.2 0.0 9.3e-05 22.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4828 PF16110.5 ORX51651.1 - 0.014 15.8 0.0 0.14 12.7 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4828) DUF4523 PF15023.6 ORX51651.1 - 0.09 12.6 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Abhydrolase_1 PF00561.20 ORX51652.1 - 3e-16 59.8 1.2 1.3e-15 57.8 1.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX51652.1 - 1.2e-10 41.1 0.0 1.8e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX51652.1 - 1.8e-10 41.8 0.1 2.5e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX51652.1 - 6.5e-08 32.3 1.0 0.0041 16.6 0.1 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family Esterase PF00756.20 ORX51652.1 - 0.0047 16.6 0.1 0.0089 15.7 0.1 1.6 1 1 0 1 1 1 1 Putative esterase Ndr PF03096.14 ORX51652.1 - 0.05 12.3 0.0 0.068 11.9 0.0 1.3 1 1 0 1 1 1 0 Ndr family GCOM2 PF15328.6 ORX51652.1 - 0.16 12.4 0.0 0.22 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 Transketolase_N PF00456.21 ORX51653.1 - 9.6e-156 517.9 0.0 1.3e-155 517.4 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 ORX51653.1 - 2.3e-43 147.9 0.0 2.2e-42 144.7 0.0 2.5 3 0 0 3 3 3 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX51653.1 - 5.1e-13 49.0 0.2 2e-12 47.1 0.2 1.9 1 1 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 ORX51653.1 - 7e-05 22.2 0.0 0.0038 16.5 0.0 2.1 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 ORX51653.1 - 0.00024 20.1 0.6 0.0006 18.8 0.0 1.9 3 0 0 3 3 3 1 Dehydrogenase E1 component Terpene_synth PF01397.21 ORX51653.1 - 0.25 11.0 0.0 0.44 10.2 0.0 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain GFO_IDH_MocA PF01408.22 ORX51654.1 - 3.8e-19 69.7 0.0 6.4e-19 69.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 ORX51654.1 - 0.00028 20.9 0.0 0.0008 19.4 0.0 1.8 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ORX51654.1 - 0.0006 20.3 0.0 0.0015 19.1 0.0 1.7 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ORX51654.1 - 0.026 14.6 0.0 0.045 13.8 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 ORX51654.1 - 0.077 12.9 0.0 0.18 11.7 0.0 1.6 2 0 0 2 2 2 0 Rossmann-like domain DCP1 PF06058.13 ORX51655.1 - 1.1e-28 99.5 0.6 1.7e-28 98.9 0.6 1.3 1 0 0 1 1 1 1 Dcp1-like decapping family mRNA_decap_C PF16741.5 ORX51655.1 - 0.0015 17.8 4.0 0.25 10.7 1.9 2.5 2 0 0 2 2 2 2 mRNA-decapping enzyme C-terminus RNA_pol_A_bac PF01000.26 ORX51656.1 - 6.2e-34 116.7 0.1 8.6e-34 116.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ORX51656.1 - 1.9e-08 33.6 0.0 2.1e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain 3Beta_HSD PF01073.19 ORX51657.1 - 2e-68 230.5 0.0 2.5e-68 230.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX51657.1 - 1.3e-32 113.2 0.0 1.8e-32 112.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX51657.1 - 1.5e-15 57.4 0.0 1.1e-14 54.6 0.0 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ORX51657.1 - 3.7e-14 52.5 0.0 4.9e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ORX51657.1 - 1.2e-13 51.4 0.0 1.7e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ORX51657.1 - 7.3e-11 41.7 0.0 1.3e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ORX51657.1 - 4.2e-09 36.0 0.1 4.9e-08 32.5 0.4 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 ORX51657.1 - 0.00092 19.2 0.3 0.13 12.1 0.3 2.5 1 1 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ORX51657.1 - 0.0015 18.8 0.2 0.35 11.1 0.0 2.5 2 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Fapy_DNA_glyco PF01149.24 ORX51658.1 - 4.3e-28 98.3 0.0 7.1e-28 97.6 0.0 1.4 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 ORX51658.1 - 6e-21 74.2 0.0 1e-20 73.5 0.0 1.3 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain V-ATPase_H_N PF03224.14 ORX51659.1 - 4.7e-85 285.6 4.5 4.7e-85 285.6 4.5 1.8 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 ORX51659.1 - 2.5e-45 153.3 4.1 9.1e-43 145.1 0.2 3.9 3 1 1 4 4 4 1 V-ATPase subunit H Arm PF00514.23 ORX51659.1 - 2.7e-06 27.2 0.8 0.062 13.4 0.0 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX51659.1 - 2.9e-05 24.4 2.3 0.029 14.7 0.0 3.3 3 0 0 3 3 3 2 HEAT repeats Terminase_2 PF03592.16 ORX51659.1 - 0.025 15.0 0.4 5.3 7.5 0.1 2.6 2 0 0 2 2 2 0 Terminase small subunit HEAT PF02985.22 ORX51659.1 - 0.29 11.5 3.3 1.8 9.0 0.0 3.7 4 0 0 4 4 4 0 HEAT repeat FKBP_C PF00254.28 ORX51660.1 - 7.8e-15 55.0 0.1 1.4e-14 54.2 0.1 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase ANAPC3 PF12895.7 ORX51660.1 - 2e-07 31.1 0.2 5.2e-07 29.8 0.2 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ORX51660.1 - 1.2e-06 28.9 1.3 0.00013 22.4 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX51660.1 - 1e-05 25.1 3.9 0.0028 17.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX51660.1 - 2.4e-05 24.0 0.6 0.23 11.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX51660.1 - 2.8e-05 23.9 4.9 0.049 13.8 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat FKBP_N_2 PF18023.1 ORX51660.1 - 9.1e-05 22.5 0.1 0.0022 18.0 0.0 2.4 2 0 0 2 2 2 1 BDBT FKBP like N-terminal TPR_6 PF13174.6 ORX51660.1 - 0.00062 20.2 1.0 0.19 12.5 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.14 ORX51660.1 - 0.0014 18.1 1.2 0.19 11.1 0.1 2.2 1 1 1 2 2 2 2 Coatomer epsilon subunit TPR_8 PF13181.6 ORX51660.1 - 0.003 17.6 0.5 0.016 15.4 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX51660.1 - 0.004 17.8 0.0 0.0076 16.9 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51660.1 - 0.006 16.8 1.0 0.038 14.3 1.0 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat DUF1039 PF06287.11 ORX51660.1 - 0.097 13.1 0.0 0.27 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1039) TPR_14 PF13428.6 ORX51660.1 - 0.11 13.4 0.2 1 10.4 0.1 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF1108 PF06531.11 ORX51660.1 - 0.12 12.7 0.3 0.37 11.1 0.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) RasGAP PF00616.19 ORX51661.1 - 2.5e-48 164.5 0.3 1e-47 162.5 0.3 2.1 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX51661.1 - 3.6e-36 124.3 2.9 2.3e-35 121.7 2.7 2.6 2 0 0 2 2 2 1 RasGAP C-terminus CH PF00307.31 ORX51661.1 - 1.2e-14 54.4 0.2 1.4e-13 51.0 0.1 2.8 2 0 0 2 2 2 1 Calponin homology (CH) domain IQ PF00612.27 ORX51661.1 - 7.7e-06 25.3 16.6 0.0029 17.3 0.1 4.5 4 0 0 4 4 4 3 IQ calmodulin-binding motif CLZ PF16526.5 ORX51661.1 - 0.016 15.6 1.9 0.016 15.6 1.9 3.7 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4844 PF16133.5 ORX51661.1 - 1.2 9.7 4.0 3.4 8.3 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4844) LSR PF05624.14 ORX51662.1 - 0.039 14.0 9.8 0.063 13.3 9.8 1.3 1 0 0 1 1 1 0 Lipolysis stimulated receptor (LSR) 7TM_GPCR_Str PF10326.9 ORX51662.1 - 0.054 12.8 0.0 0.063 12.6 0.0 1.0 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str Prominin PF05478.11 ORX51662.1 - 0.13 10.1 2.3 0.15 10.0 2.3 1.0 1 0 0 1 1 1 0 Prominin Herpes_pp38 PF04846.13 ORX51662.1 - 0.18 11.7 2.2 0.24 11.3 2.2 1.1 1 0 0 1 1 1 0 Herpesvirus pp38 phosphoprotein PPR_2 PF13041.6 ORX51663.1 - 8.5e-10 38.7 8.5 1.5e-05 25.1 0.0 6.7 9 1 2 11 11 11 2 PPR repeat family PPR_1 PF12854.7 ORX51663.1 - 1.7e-09 37.2 0.7 2.4e-07 30.3 0.0 3.5 5 0 0 5 5 5 1 PPR repeat PPR PF01535.20 ORX51663.1 - 2.5e-08 33.6 0.5 0.00073 19.6 0.0 5.5 6 0 0 6 6 6 1 PPR repeat PPR_3 PF13812.6 ORX51663.1 - 1e-07 31.9 1.6 0.00019 21.5 0.1 4.1 4 1 0 5 5 5 1 Pentatricopeptide repeat domain RhoGEF PF00621.20 ORX51664.1 - 7.8e-29 101.2 0.1 2.4e-28 99.6 0.1 1.9 1 0 0 1 1 1 1 RhoGEF domain PH_13 PF16652.5 ORX51664.1 - 0.00016 21.5 1.1 0.0004 20.2 0.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ORX51664.1 - 0.0017 18.3 0.1 0.0055 16.7 0.1 1.9 1 1 0 1 1 1 1 PH domain PH_10 PF15411.6 ORX51664.1 - 0.003 17.8 0.2 0.014 15.6 0.2 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX51664.1 - 0.017 15.6 3.6 0.025 15.1 1.0 2.5 2 1 0 2 2 2 0 PH domain PH_16 PF17838.1 ORX51664.1 - 0.023 14.5 0.2 2.5 7.9 0.1 3.2 3 0 0 3 3 3 0 PH domain SBP_bac_6 PF13343.6 ORX51664.1 - 0.077 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein MMS22L_C PF14911.6 ORX51664.1 - 0.12 11.4 1.7 8 5.4 0.1 2.5 3 0 0 3 3 3 0 S-phase genomic integrity recombination mediator, C-terminal MFS_1 PF07690.16 ORX51665.1 - 3.9e-32 111.6 22.9 4.5e-32 111.4 22.9 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ORX51665.1 - 0.82 7.9 13.4 0.053 11.8 1.1 2.8 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF3040 PF11239.8 ORX51665.1 - 2.8 8.3 5.8 16 5.8 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DEAD PF00270.29 ORX51666.1 - 1.9e-12 47.3 0.1 2.5e-12 46.9 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX51666.1 - 3.6e-05 24.0 0.1 7.4e-05 23.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX51666.1 - 0.00061 19.8 0.0 0.47 10.5 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ORX51666.1 - 0.0009 19.6 0.0 0.0014 19.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX51666.1 - 0.00094 19.7 0.1 0.002 18.6 0.1 1.3 1 1 0 1 1 1 1 ABC transporter ResIII PF04851.15 ORX51666.1 - 0.0017 18.4 0.0 0.0065 16.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 ORX51666.1 - 0.002 17.2 0.2 0.0061 15.7 0.0 1.8 1 1 1 2 2 2 1 Type II/IV secretion system protein ATPase PF06745.13 ORX51666.1 - 0.0025 17.2 0.2 0.0057 16.0 0.2 1.6 1 1 0 1 1 1 1 KaiC Rad17 PF03215.15 ORX51666.1 - 0.0095 15.9 0.3 0.046 13.6 0.0 1.9 2 0 0 2 2 2 1 Rad17 P-loop domain PhoH PF02562.16 ORX51666.1 - 0.011 15.2 0.1 0.03 13.8 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 ORX51666.1 - 0.015 15.7 0.1 0.026 14.9 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ORX51666.1 - 0.017 15.1 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase DAP3 PF10236.9 ORX51666.1 - 0.021 14.0 0.0 0.031 13.4 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NACHT PF05729.12 ORX51666.1 - 0.051 13.5 0.1 0.81 9.6 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 ORX51666.1 - 0.081 12.6 0.0 0.13 12.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ORX51666.1 - 0.091 12.9 0.0 0.67 10.1 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Helicase_RecD PF05127.14 ORX51666.1 - 0.1 12.5 0.0 0.16 11.8 0.0 1.4 1 1 0 1 1 1 0 Helicase RNA_helicase PF00910.22 ORX51666.1 - 0.11 12.9 0.0 0.33 11.4 0.0 1.8 2 0 0 2 2 2 0 RNA helicase AAA_11 PF13086.6 ORX51666.1 - 0.14 11.9 0.2 13 5.5 0.0 2.1 1 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX51666.1 - 0.15 11.3 0.0 0.61 9.3 0.0 1.9 1 1 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 ORX51666.1 - 0.15 11.6 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ORX51666.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX51666.1 - 0.17 12.4 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain TPR_11 PF13414.6 ORX51668.1 - 2.5e-08 33.5 1.2 0.0042 16.7 0.0 2.4 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 ORX51668.1 - 4.2e-08 32.7 7.0 0.0052 16.6 0.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat Lactamase_B PF00753.27 ORX51668.1 - 1e-07 32.2 4.9 2e-06 28.0 4.9 2.2 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily TPR_2 PF07719.17 ORX51668.1 - 6.8e-07 28.9 4.6 0.041 14.0 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51668.1 - 8.8e-06 25.9 5.0 0.047 14.0 2.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat Lactamase_B_2 PF12706.7 ORX51668.1 - 0.00069 19.2 0.5 0.0016 18.0 0.5 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TPR_7 PF13176.6 ORX51668.1 - 0.0022 17.9 2.4 0.033 14.2 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ORX51668.1 - 0.0026 17.2 0.3 1.5 8.4 0.0 2.4 2 0 0 2 2 2 2 SHNi-TPR TPR_8 PF13181.6 ORX51668.1 - 0.0055 16.8 5.6 0.2 12.0 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 ORX51668.1 - 0.027 14.5 0.2 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 ORX51668.1 - 0.033 14.3 2.7 4.6 7.4 0.1 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ORX51668.1 - 0.037 14.9 0.5 0.21 12.5 0.1 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat COR PF16095.5 ORX51668.1 - 0.088 12.6 0.0 0.46 10.3 0.0 1.9 1 1 1 2 2 2 0 C-terminal of Roc, COR, domain TPR_19 PF14559.6 ORX51668.1 - 0.16 12.5 1.8 1.5 9.4 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX51668.1 - 0.46 10.5 3.7 6.3 6.9 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Aa_trans PF01490.18 ORX51669.1 - 5e-61 206.6 24.2 5.9e-61 206.4 24.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Spore_permease PF03845.13 ORX51669.1 - 0.00064 18.6 12.4 0.00064 18.6 12.4 2.7 3 1 0 3 3 3 1 Spore germination protein DUF4605 PF15378.6 ORX51669.1 - 0.028 14.3 1.0 0.99 9.3 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4605) LMF1 PF06762.14 ORX51669.1 - 0.13 11.4 3.5 0.062 12.4 0.3 1.8 2 0 0 2 2 2 0 Lipase maturation factor Peptidase_S8 PF00082.22 ORX51670.1 - 8.2e-46 156.6 0.1 1.2e-45 156.1 0.1 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX51670.1 - 2.5e-08 33.8 0.1 7.4e-08 32.3 0.1 1.8 1 0 0 1 1 1 1 PA domain fn3_5 PF06280.12 ORX51670.1 - 3.6e-08 34.1 0.0 1.5e-07 32.1 0.0 2.0 2 0 0 2 2 2 1 Fn3-like domain PIG-Y PF15159.6 ORX51672.1 - 0.19 12.7 2.0 2.6 9.0 0.1 2.3 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y FAM72 PF14976.6 ORX51673.1 - 1.3e-38 132.4 0.3 2.2e-38 131.7 0.3 1.3 1 0 0 1 1 1 1 FAM72 protein Pkinase PF00069.25 ORX51674.1 - 1.3e-07 31.2 0.0 2e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SKG6 PF08693.10 ORX51674.1 - 0.017 14.5 1.4 0.034 13.6 1.4 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 ORX51674.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain F-box-like PF12937.7 ORX51675.1 - 1.4e-10 40.8 0.1 3.6e-10 39.6 0.1 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX51675.1 - 3.7e-08 33.0 0.1 1.6e-07 31.1 0.0 2.1 2 1 0 2 2 2 1 F-box domain DUF4120 PF13496.6 ORX51675.1 - 0.091 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4120) Ssl1 PF04056.14 ORX51676.1 - 3.3e-82 275.0 0.0 4.4e-82 274.6 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 ORX51676.1 - 2.5e-14 53.3 24.6 1.2e-13 51.1 13.2 2.7 2 0 0 2 2 2 2 TFIIH C1-like domain VWA_2 PF13519.6 ORX51676.1 - 4.2e-14 53.1 0.1 1.6e-13 51.2 0.0 2.0 3 0 0 3 3 3 1 von Willebrand factor type A domain Tfb4 PF03850.14 ORX51676.1 - 4.9e-06 26.2 0.1 7e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Transcription factor Tfb4 IBR PF01485.21 ORX51676.1 - 0.00032 20.9 9.0 0.00032 20.9 9.0 2.5 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain VWA PF00092.28 ORX51676.1 - 0.00035 20.9 0.0 0.00057 20.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-RING_4 PF14570.6 ORX51676.1 - 3.2 7.6 17.7 10 6.0 9.7 2.9 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF4428 PF14471.6 ORX51676.1 - 4.6 7.3 13.3 1.1 9.3 5.2 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) Ceramidase PF05875.12 ORX51678.1 - 1.2e-51 175.7 28.1 1.5e-51 175.4 28.1 1.0 1 0 0 1 1 1 1 Ceramidase NiFe_hyd_3_EhaA PF17367.2 ORX51678.1 - 0.031 14.4 0.1 0.073 13.2 0.1 1.6 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A Gti1_Pac2 PF09729.9 ORX51679.1 - 6e-44 150.3 3.4 2.2e-37 128.9 0.3 2.0 1 1 1 2 2 2 2 Gti1/Pac2 family WRC PF08879.10 ORX51679.1 - 0.12 12.1 0.6 0.12 12.1 0.6 1.9 2 0 0 2 2 2 0 WRC PBCV_basic_adap PF08789.10 ORX51682.1 - 0.01 15.9 0.6 0.13 12.4 0.1 2.2 2 0 0 2 2 2 0 PBCV-specific basic adaptor domain Tautomerase_2 PF14552.6 ORX51682.1 - 0.073 13.2 0.0 0.081 13.0 0.0 1.2 1 0 0 1 1 1 0 Tautomerase enzyme DUF1541 PF07563.11 ORX51682.1 - 0.21 11.5 0.4 0.35 10.8 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1541) HPP PF04982.13 ORX51684.1 - 7.7e-39 132.6 8.4 7.7e-39 132.6 8.4 1.6 2 0 0 2 2 2 1 HPP family DUF3792 PF12670.7 ORX51684.1 - 0.031 14.5 5.3 0.16 12.1 5.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3792) PIRT PF15099.6 ORX51684.1 - 0.073 12.7 0.4 1.6 8.3 0.4 2.4 1 1 0 1 1 1 0 Phosphoinositide-interacting protein family Neurochondrin PF05536.11 ORX51685.1 - 9.5e-51 172.9 4.7 1.7e-50 172.0 4.7 1.4 1 1 0 1 1 1 1 Neurochondrin MOR2-PAG1_C PF14225.6 ORX51685.1 - 0.0073 16.2 3.0 0.96 9.3 1.6 3.4 2 1 0 2 2 2 1 Cell morphogenesis C-terminal zf-rbx1 PF12678.7 ORX51686.1 - 3.7e-25 88.0 13.0 6e-25 87.3 13.0 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX51686.1 - 1.1e-16 60.6 10.8 1.6e-16 60.1 10.8 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 ORX51686.1 - 2.4e-06 27.8 14.5 8.8e-05 22.8 14.5 2.3 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX51686.1 - 4.8e-05 23.1 3.1 4.8e-05 23.1 3.1 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX51686.1 - 0.00098 18.9 11.7 0.017 14.9 11.7 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX51686.1 - 0.11 12.4 10.7 0.33 10.8 4.4 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX51686.1 - 0.32 10.8 15.8 26 4.6 15.8 2.4 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX51686.1 - 0.49 10.5 7.5 1.8 8.6 7.5 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 ORX51686.1 - 0.54 10.5 9.3 2.9 8.1 9.5 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 ORX51686.1 - 1.2 8.8 15.0 0.3 10.7 4.9 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ORX51686.1 - 7.1 6.7 12.3 61 3.7 12.3 2.5 1 1 0 1 1 1 0 zinc-RING finger domain zf-U1 PF06220.12 ORX51687.1 - 8.1e-08 31.9 6.0 1.4e-07 31.1 6.0 1.4 1 0 0 1 1 1 1 U1 zinc finger zf-CCCH PF00642.24 ORX51687.1 - 1.2e-05 25.0 0.7 1.2e-05 25.0 0.7 1.6 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ORX51687.1 - 0.0084 15.9 1.9 0.016 15.0 1.9 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Opi1 PF08618.10 ORX51688.1 - 5.3e-53 180.8 19.5 2.5e-43 148.9 6.7 3.7 2 1 2 4 4 4 3 Transcription factor Opi1 DUF3450 PF11932.8 ORX51688.1 - 0.0022 17.3 0.1 0.0038 16.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Ribosomal_L30_N PF08079.12 ORX51689.1 - 5.8e-26 90.5 14.8 1e-25 89.8 14.8 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 ORX51689.1 - 4.9e-18 64.7 1.2 9.5e-18 63.8 1.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Pkinase PF00069.25 ORX51691.1 - 2.6e-71 240.1 0.0 5.7e-71 239.0 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51691.1 - 2.9e-32 112.0 0.0 9.3e-32 110.3 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX51691.1 - 0.0001 21.7 1.5 0.26 10.6 0.1 3.1 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 ORX51691.1 - 0.00013 21.0 0.3 0.00021 20.4 0.3 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX51691.1 - 0.0027 16.5 0.2 0.0077 15.0 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ORX51691.1 - 0.0074 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2322 PF10084.9 ORX51691.1 - 0.13 12.4 1.7 45 4.2 0.2 3.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2322) RIO1 PF01163.22 ORX51691.1 - 0.15 11.7 3.4 0.68 9.5 3.4 2.0 1 1 0 1 1 1 0 RIO1 family DASH_Ask1 PF08655.10 ORX51692.1 - 4.4e-21 74.5 0.7 8e-21 73.7 0.7 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Prok-RING_1 PF14446.6 ORX51695.1 - 0.33 10.9 10.9 0.27 11.2 4.4 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-CCHC_6 PF15288.6 ORX51695.1 - 7.3 6.5 10.5 14 5.6 1.8 2.6 2 0 0 2 2 2 0 Zinc knuckle OrfB_Zn_ribbon PF07282.11 ORX51696.1 - 1.6e-05 24.8 4.1 1.6e-05 24.8 4.1 2.9 2 1 0 2 2 2 1 Putative transposase DNA-binding domain LEA_2 PF03168.13 ORX51697.1 - 0.0015 19.0 0.0 0.0021 18.6 0.0 1.2 1 0 0 1 1 1 1 Late embryogenesis abundant protein Meth_synt_2 PF01717.18 ORX51698.1 - 7.9e-158 524.9 0.0 1.9e-148 494.1 0.0 2.3 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 ORX51698.1 - 1.3e-115 386.3 0.0 2.9e-108 362.1 0.0 3.0 3 0 0 3 3 3 2 Cobalamin-independent synthase, N-terminal domain Acetyltransf_10 PF13673.7 ORX51699.1 - 4.5e-11 42.8 0.0 5.8e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX51699.1 - 5.4e-10 39.6 0.0 1.1e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX51699.1 - 5.4e-08 33.1 0.0 8.1e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family PanZ PF12568.8 ORX51699.1 - 0.016 14.9 0.1 0.017 14.8 0.1 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 ORX51699.1 - 0.018 15.1 0.0 0.023 14.8 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX51700.1 - 1.9e-10 40.8 0.1 2.3e-10 40.5 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX51700.1 - 2.7e-09 37.3 0.1 3.5e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX51700.1 - 3.6e-05 24.1 0.0 6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.7 ORX51700.1 - 0.0032 17.6 0.0 0.0044 17.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX51700.1 - 0.035 14.1 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Ribosomal_L38e PF01781.18 ORX51701.1 - 2.8e-32 110.6 3.8 3.4e-32 110.4 3.8 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family TFIID_NTD2 PF04494.15 ORX51701.1 - 0.03 14.6 0.2 0.035 14.4 0.2 1.1 1 0 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain RhoGAP PF00620.27 ORX51702.1 - 7.2e-09 35.6 0.0 1.9e-08 34.3 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 ORX51702.1 - 1.4e-08 34.9 3.4 7.7e-08 32.5 0.9 3.1 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.21 ORX51702.1 - 5.4e-08 32.8 0.0 2.5e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Collagen_mid PF15984.5 ORX51702.1 - 0.0012 18.6 1.4 0.0021 17.8 1.4 1.3 1 0 0 1 1 1 1 Bacterial collagen, middle region Sec16 PF12932.7 ORX51702.1 - 0.4 11.3 2.7 14 6.3 0.1 3.2 3 0 0 3 3 3 0 Vesicle coat trafficking protein Sec16 mid-region DUF2470 PF10615.9 ORX51703.1 - 1.4e-11 44.9 0.0 2.1e-11 44.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 ORX51703.1 - 2.3e-10 40.6 1.1 5e-10 39.6 1.0 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4499) YndJ PF14158.6 ORX51703.1 - 0.049 12.9 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 YndJ-like protein BPL_N PF09825.9 ORX51705.1 - 2.8e-105 352.5 0.0 3.5e-105 352.2 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 ORX51705.1 - 8.4e-23 80.7 0.0 1.5e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 ORX51705.1 - 1.9e-07 30.9 0.0 3.6e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain GATase_3 PF07685.14 ORX51705.1 - 0.039 13.5 0.0 0.07 12.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain ODC_AZ PF02100.17 ORX51706.1 - 1.6e-06 28.1 0.0 2e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Glucosamine_iso PF01182.20 ORX51707.1 - 1.5e-19 70.8 0.0 2.2e-19 70.2 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase zf-C3HC PF07967.13 ORX51708.1 - 2.3e-18 66.5 0.3 3.2e-12 46.6 0.1 2.4 2 0 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 ORX51708.1 - 1.4e-08 34.8 1.7 2.4e-08 34.0 0.2 2.2 2 0 0 2 2 2 1 Rsm1-like DFRP_C PF16543.5 ORX51708.1 - 0.0054 17.2 0.1 0.013 16.0 0.1 1.6 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 BIR PF00653.21 ORX51708.1 - 0.091 13.4 0.6 4.6 8.0 0.0 3.0 3 0 0 3 3 3 0 Inhibitor of Apoptosis domain VHP PF02209.19 ORX51708.1 - 0.17 12.0 0.8 0.37 10.9 0.8 1.5 1 0 0 1 1 1 0 Villin headpiece domain VCX_VCY PF15231.6 ORX51708.1 - 0.72 10.5 32.0 26 5.5 16.4 3.3 1 1 1 2 2 2 0 Variable charge X/Y family Tyr-DNA_phospho PF06087.12 ORX51710.1 - 4.2e-49 167.6 0.0 5.7e-49 167.2 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 ORX51710.1 - 0.04 13.8 0.0 0.49 10.3 0.0 2.1 2 0 0 2 2 2 0 PLD-like domain Fe_hyd_SSU PF02256.17 ORX51710.1 - 0.12 12.5 0.4 4.7 7.4 0.0 2.5 2 0 0 2 2 2 0 Iron hydrogenase small subunit Mur_ligase_M PF08245.12 ORX51711.1 - 3.6e-08 33.6 1.3 1.9e-05 24.8 1.3 3.4 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 ORX51711.1 - 0.0095 16.2 0.0 0.034 14.4 0.0 2.0 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain MIT PF04212.18 ORX51712.1 - 2.9e-12 46.5 1.5 5.5e-12 45.6 1.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DIL PF01843.19 ORX51712.1 - 0.99 9.7 5.0 4.2 7.7 0.3 2.9 2 1 1 3 3 3 0 DIL domain DUF4400 PF14348.6 ORX51712.1 - 1.9 7.9 6.1 0.2 11.2 0.3 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4400) Arrestin_C PF02752.22 ORX51714.1 - 1.1e-06 29.1 1.4 5.1e-06 27.0 0.7 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX51714.1 - 4.2e-05 23.6 0.9 0.0022 18.1 0.2 2.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain AMP-binding_C PF13193.6 ORX51715.1 - 4.9e-07 30.6 0.0 1e-06 29.6 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 ORX51715.1 - 0.0023 16.6 0.0 0.003 16.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme SulA PF03846.14 ORX51715.1 - 0.095 12.6 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Cell division inhibitor SulA CSN8_PSD8_EIF3K PF10075.9 ORX51716.1 - 4.5e-31 107.8 0.3 7.3e-31 107.1 0.3 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 ORX51716.1 - 2.4e-05 23.9 0.0 3.5e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 SAC3/GANP family DUF4675 PF15720.5 ORX51716.1 - 0.08 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4675) Glyco_hydro_14 PF01373.17 ORX51716.1 - 0.12 11.3 0.0 0.14 11.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 XhlA PF10779.9 ORX51717.1 - 0.039 14.1 0.6 5.5 7.3 0.3 2.7 2 0 0 2 2 2 0 Haemolysin XhlA TPR_MLP1_2 PF07926.12 ORX51717.1 - 0.066 13.3 19.1 0.33 11.0 9.2 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Nrap_D5 PF17406.2 ORX51717.1 - 0.067 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 FlaC_arch PF05377.11 ORX51717.1 - 0.068 13.6 0.8 2.1 8.8 0.1 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Sec34 PF04136.15 ORX51717.1 - 0.86 9.5 10.3 0.23 11.3 1.7 2.8 3 0 0 3 3 3 0 Sec34-like family SH3_9 PF14604.6 ORX51719.1 - 2.2e-11 43.4 0.0 3.1e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX51719.1 - 3.1e-08 33.1 0.0 4.8e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX51719.1 - 1.7e-07 30.8 0.0 2.2e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SNARE_assoc PF09335.11 ORX51720.1 - 2e-19 70.2 5.4 2e-19 70.2 5.4 2.2 3 1 0 3 3 3 1 SNARE associated Golgi protein Dna2 PF08696.11 ORX51721.1 - 7.5e-48 163.0 0.0 1.2e-47 162.4 0.0 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 AAA_11 PF13086.6 ORX51721.1 - 2.4e-16 60.3 0.6 3e-12 46.9 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_12 PF13087.6 ORX51721.1 - 8.3e-12 45.1 0.1 1.5e-11 44.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX51721.1 - 9e-12 45.1 0.3 1.7e-09 37.7 0.2 2.4 1 1 1 2 2 2 1 AAA domain Cas_Cas4 PF01930.17 ORX51721.1 - 2.2e-08 34.4 0.3 2e-06 28.0 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF83 AAA_19 PF13245.6 ORX51721.1 - 3.2e-08 34.0 1.0 1.1e-06 29.1 0.2 2.5 1 1 1 2 2 2 1 AAA domain SRP54 PF00448.22 ORX51721.1 - 0.00011 21.9 0.1 0.0003 20.5 0.0 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain PDDEXK_1 PF12705.7 ORX51721.1 - 0.00041 20.3 0.0 0.00092 19.2 0.0 1.7 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily PIF1 PF05970.14 ORX51721.1 - 0.00082 18.6 0.4 0.03 13.5 0.1 2.3 1 1 1 2 2 2 1 PIF1-like helicase Viral_helicase1 PF01443.18 ORX51721.1 - 0.00084 19.1 2.4 1 9.1 0.1 3.1 2 1 1 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 ORX51721.1 - 0.0044 16.9 0.0 0.0081 16.0 0.0 1.4 1 0 0 1 1 1 1 Helicase UvrD-helicase PF00580.21 ORX51721.1 - 0.0048 16.5 0.1 0.012 15.2 0.1 1.6 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain DUF87 PF01935.17 ORX51721.1 - 0.017 15.3 0.1 0.031 14.4 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain DUF3447 PF11929.8 ORX51721.1 - 0.019 14.9 0.7 0.13 12.2 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) AAA_16 PF13191.6 ORX51721.1 - 0.024 15.0 0.0 0.056 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain CbiA PF01656.23 ORX51721.1 - 0.034 14.2 0.4 0.08 13.0 0.4 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 ORX51721.1 - 0.041 13.8 0.1 0.086 12.7 0.1 1.5 1 0 0 1 1 1 0 NTPase MeaB PF03308.16 ORX51721.1 - 0.044 12.8 0.0 0.074 12.0 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATPase PF06745.13 ORX51721.1 - 0.051 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 KaiC ResIII PF04851.15 ORX51721.1 - 0.055 13.5 0.1 0.16 11.9 0.0 1.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit RuvB_N PF05496.12 ORX51721.1 - 0.061 13.1 0.0 0.19 11.5 0.0 1.8 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ORX51721.1 - 0.064 13.7 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX51721.1 - 0.077 13.0 0.2 0.19 11.7 0.2 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX51721.1 - 0.078 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ORX51721.1 - 0.13 12.0 0.2 2.1 8.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain Tudor_1_RapA PF18339.1 ORX51721.1 - 0.14 12.1 0.0 0.47 10.4 0.0 1.8 2 0 0 2 2 1 0 RapA N-terminal Tudor like domain 1 AAA_22 PF13401.6 ORX51721.1 - 0.16 12.2 0.0 0.43 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Det1 PF09737.9 ORX51722.1 - 8.1e-64 216.2 3.4 6e-40 137.6 0.0 2.1 2 0 0 2 2 2 2 De-etiolated protein 1 Det1 zf-MYND PF01753.18 ORX51723.1 - 3e-06 27.2 17.5 3e-06 27.2 17.5 2.4 2 0 0 2 2 2 1 MYND finger DUF3106 PF11304.8 ORX51723.1 - 0.063 13.8 7.2 0.15 12.6 7.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) SelP_N PF04592.14 ORX51723.1 - 3.8 6.8 13.0 9.5 5.5 13.0 1.7 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RSN1_7TM PF02714.15 ORX51724.1 - 7.6e-83 278.0 27.2 1.4e-82 277.1 27.2 1.4 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ORX51724.1 - 5.9e-37 127.6 0.9 4.5e-36 124.7 0.1 2.2 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ORX51724.1 - 7e-14 51.9 0.6 7e-14 51.9 0.6 2.7 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 ORX51724.1 - 1.4e-09 38.0 0.1 4.2e-09 36.5 0.1 1.8 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Anoctamin PF04547.12 ORX51724.1 - 0.016 14.0 5.8 0.021 13.7 4.3 1.8 1 1 1 2 2 2 0 Calcium-activated chloride channel RhoGEF PF00621.20 ORX51726.1 - 2.8e-29 102.7 3.0 2.8e-29 102.7 3.0 2.2 2 0 0 2 2 2 1 RhoGEF domain PH_10 PF15411.6 ORX51726.1 - 0.017 15.4 0.0 0.059 13.6 0.0 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain PDZ_5 PF17817.1 ORX51727.1 - 0.0068 16.7 0.6 0.041 14.2 0.1 2.1 2 0 0 2 2 2 1 PDZ domain MCM PF00493.23 ORX51728.1 - 5.6e-100 333.0 0.5 8.1e-100 332.5 0.5 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX51728.1 - 2.1e-37 127.8 0.3 3.9e-37 126.9 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX51728.1 - 3.8e-29 101.0 1.0 8.7e-29 99.8 1.0 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 ORX51728.1 - 2.2e-22 80.0 17.8 2.2e-22 80.0 17.8 3.8 5 0 0 5 5 4 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 ORX51728.1 - 3.6e-14 53.2 0.8 8.5e-14 52.0 0.1 2.0 2 0 0 2 2 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX51728.1 - 7.5e-09 35.3 0.1 7.6e-07 28.7 0.0 2.5 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX51728.1 - 2.2e-05 24.5 0.0 0.00016 21.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ORX51728.1 - 0.00014 21.7 0.0 0.0016 18.3 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX51728.1 - 0.02 14.6 0.1 0.17 11.6 0.1 2.2 1 1 0 1 1 1 0 Sigma-54 interaction domain C1_4 PF07975.12 ORX51728.1 - 0.066 13.5 0.5 0.16 12.2 0.5 1.6 1 0 0 1 1 1 0 TFIIH C1-like domain AAA_lid_2 PF17863.1 ORX51728.1 - 0.069 13.0 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 AAA lid domain UIM PF02809.20 ORX51728.1 - 0.071 13.1 0.2 0.28 11.2 0.2 2.1 1 0 0 1 1 1 0 Ubiquitin interaction motif Colicin-DNase PF12639.7 ORX51728.1 - 0.12 13.3 0.1 0.35 11.7 0.1 1.8 1 0 0 1 1 1 0 DNase/tRNase domain of colicin-like bacteriocin zf-TFIIB PF13453.6 ORX51728.1 - 0.99 8.8 2.5 1.3 8.4 1.4 1.8 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-C2H2 PF00096.26 ORX51729.1 - 6.7e-19 67.2 20.2 1.5e-07 31.5 2.4 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX51729.1 - 2.5e-17 62.4 20.6 3.6e-08 33.5 1.8 3.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX51729.1 - 1.1e-12 47.6 16.2 0.00075 20.1 0.6 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX51729.1 - 2.4e-10 40.2 8.7 0.00014 21.8 0.4 3.4 3 1 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX51729.1 - 3e-09 36.9 6.0 0.037 14.3 0.7 3.2 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX51729.1 - 1.1e-08 35.2 7.2 0.0052 17.1 0.7 3.3 3 0 0 3 3 3 3 Zinc-finger of C2H2 type C5HCH PF17982.1 ORX51729.1 - 0.0058 16.8 12.3 0.017 15.3 1.1 3.1 2 1 1 3 3 3 2 NSD Cys-His rich domain zf-C2HC_2 PF13913.6 ORX51729.1 - 0.022 14.7 0.5 0.022 14.7 0.5 2.9 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 ORX51729.1 - 0.025 14.3 8.0 0.21 11.4 0.1 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type PyrI_C PF02748.15 ORX51729.1 - 0.05 13.5 3.0 1.3 9.0 0.1 2.9 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Zn-ribbon_8 PF09723.10 ORX51729.1 - 0.15 12.2 7.7 5.5 7.2 0.2 2.6 2 1 1 3 3 3 0 Zinc ribbon domain Prok-RING_1 PF14446.6 ORX51729.1 - 0.16 11.9 3.3 11 6.1 0.1 2.7 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zinc-ribbons_6 PF07191.12 ORX51729.1 - 0.26 11.3 4.8 0.29 11.2 0.9 2.4 1 1 1 2 2 2 0 zinc-ribbons zf-C2H2_2 PF12756.7 ORX51729.1 - 0.29 11.5 5.5 4.8 7.6 0.6 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf_ZIC PF18366.1 ORX51729.1 - 0.43 10.7 4.2 10 6.3 0.1 3.1 2 1 1 3 3 3 0 Zic proteins zinc finger domain zf-AN1 PF01428.16 ORX51729.1 - 0.52 10.5 15.7 4.1 7.7 2.6 3.1 1 1 2 3 3 3 0 AN1-like Zinc finger C1_4 PF07975.12 ORX51729.1 - 0.85 9.9 10.6 0.35 11.1 0.4 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain UBZ_FAAP20 PF15750.5 ORX51729.1 - 3.1 7.8 9.9 1.7 8.7 0.6 2.7 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger UBN_AB PF14075.6 ORX51730.1 - 1e-05 25.4 0.8 1.2e-05 25.2 0.0 1.5 2 0 0 2 2 2 1 Ubinuclein conserved middle domain DUF148 PF02520.17 ORX51730.1 - 0.25 11.5 0.9 0.43 10.7 0.9 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF148 UBN_AB PF14075.6 ORX51731.1 - 3e-11 43.4 7.5 7.4e-07 29.1 0.0 2.7 3 0 0 3 3 3 2 Ubinuclein conserved middle domain HUN PF08729.10 ORX51731.1 - 1.2e-08 34.9 5.4 2.8e-08 33.6 5.4 1.6 1 0 0 1 1 1 1 HPC2 and ubinuclein domain Dicty_REP PF05086.12 ORX51731.1 - 0.047 11.7 0.6 0.06 11.3 0.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tmemb_cc2 PF10267.9 ORX51731.1 - 0.059 12.5 0.5 0.099 11.8 0.5 1.3 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Ndc1_Nup PF09531.10 ORX51731.1 - 0.19 10.4 1.9 0.24 10.1 1.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Apt1 PF10351.9 ORX51731.1 - 0.46 9.3 6.6 0.65 8.8 6.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ORX51731.1 - 1.1 7.8 9.2 1.5 7.3 9.2 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 ORX51731.1 - 1.6 7.8 12.4 2.4 7.3 12.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Dynamin_N PF00350.23 ORX51732.1 - 2e-17 63.8 0.3 8.1e-17 61.8 0.1 2.3 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 ORX51732.1 - 8.1e-12 45.2 0.1 2.2e-09 37.4 0.1 3.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX51732.1 - 3.9e-08 33.1 1.4 7.1e-07 29.0 1.2 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX51732.1 - 0.00025 21.0 3.2 0.46 10.4 0.1 3.9 3 1 0 3 3 3 2 RsgA GTPase cobW PF02492.19 ORX51732.1 - 0.0015 18.1 0.2 0.26 10.8 0.2 2.5 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ORX51732.1 - 0.01 15.6 0.0 0.023 14.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TsaE PF02367.17 ORX51732.1 - 0.011 15.8 0.0 0.098 12.7 0.0 2.4 1 1 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 ORX51732.1 - 0.02 15.1 0.0 1.2 9.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase HBB PF06777.11 ORX51732.1 - 0.029 14.1 0.0 0.11 12.1 0.0 2.0 1 0 0 1 1 1 0 Helical and beta-bridge domain Stk19 PF10494.9 ORX51732.1 - 0.045 13.4 0.3 0.045 13.4 0.3 2.5 3 0 0 3 3 3 0 Serine-threonine protein kinase 19 FeoB_N PF02421.18 ORX51732.1 - 0.077 12.5 0.9 13 5.3 0.0 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B Sigma54_activat PF00158.26 ORX51732.1 - 0.093 12.4 0.0 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF948 PF06103.11 ORX51732.1 - 0.13 12.5 1.0 10 6.5 0.1 3.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) AAA_16 PF13191.6 ORX51732.1 - 0.51 10.7 3.2 1.8 8.9 0.0 3.4 3 1 0 3 3 3 0 AAA ATPase domain DUF615 PF04751.14 ORX51732.1 - 0.52 10.3 8.7 0.031 14.3 1.5 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF615) Homeodomain PF00046.29 ORX51875.1 - 2.2e-19 69.1 0.7 2.3e-19 68.9 0.7 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX51875.1 - 0.0022 17.8 0.2 0.0033 17.3 0.2 1.2 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 ORX51875.1 - 0.0053 16.6 0.1 0.0072 16.2 0.1 1.3 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_23 PF13384.6 ORX51875.1 - 0.006 16.3 0.0 0.0091 15.8 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain MerR_1 PF13411.6 ORX51875.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 2 0 0 2 2 2 0 MerR HTH family regulatory protein TLD PF07534.16 ORX51876.1 - 1.2e-33 116.3 0.5 1.6e-33 115.9 0.5 1.2 1 0 0 1 1 1 1 TLD zf_CCCH_5 PF18384.1 ORX51876.1 - 0.059 13.5 0.1 5.9 7.1 0.0 2.7 2 0 0 2 2 2 0 Unkempt Zinc finger domain 1 (Znf1) Pkinase PF00069.25 ORX51877.1 - 9.4e-42 143.2 0.0 5.7e-41 140.6 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51877.1 - 1.4e-19 70.4 0.0 2e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ORX51877.1 - 0.046 13.3 0.2 0.29 10.7 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ORX51877.1 - 0.073 12.4 0.0 0.18 11.1 0.0 1.6 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 ORX51877.1 - 0.37 9.5 2.8 0.91 8.2 0.1 2.1 1 1 1 2 2 2 0 Fungal protein kinase Histone PF00125.24 ORX51878.1 - 8.6e-53 178.2 2.6 9.5e-53 178.0 2.6 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX51878.1 - 2.3e-05 24.7 0.0 3.5e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX51878.1 - 2.6e-05 24.3 0.5 4.8e-05 23.4 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ORX51878.1 - 5.5e-05 23.8 1.2 6.6e-05 23.5 1.2 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ORX51878.1 - 0.0058 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX51878.1 - 0.059 13.5 0.1 0.094 12.8 0.0 1.4 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX51878.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated PCI PF01399.27 ORX51879.1 - 1.4e-07 32.0 2.8 4.2e-07 30.4 0.1 2.9 2 2 0 2 2 2 1 PCI domain FAD_binding_1 PF00667.20 ORX51879.1 - 0.17 11.4 1.7 1.5 8.4 0.3 2.3 2 0 0 2 2 2 0 FAD binding domain RRM_1 PF00076.22 ORX51880.1 - 5.8e-14 51.7 0.0 9.5e-14 51.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PX PF00787.24 ORX51881.1 - 2e-19 69.6 0.0 4.9e-19 68.4 0.0 1.6 1 0 0 1 1 1 1 PX domain RrnaAD PF00398.20 ORX51882.1 - 7.6e-49 166.1 0.0 9.2e-49 165.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ORX51882.1 - 0.0089 16.7 0.0 0.021 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Amdase PF17645.1 ORX51882.1 - 0.032 13.9 0.0 0.051 13.2 0.0 1.3 1 0 0 1 1 1 0 Arylmalonate decarboxylase DUF4312 PF14189.6 ORX51882.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) 3-HAO PF06052.12 ORX51883.1 - 4e-60 201.8 0.1 4.5e-60 201.7 0.1 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ORX51883.1 - 1.2e-08 34.5 0.0 1.9e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ORX51883.1 - 7e-06 25.7 0.0 1e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 ORX51883.1 - 2.8e-05 24.0 0.0 4.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain ARD PF03079.14 ORX51883.1 - 0.0019 18.4 0.1 0.0039 17.4 0.1 1.4 1 1 0 1 1 1 1 ARD/ARD' family RecQ_Zn_bind PF16124.5 ORX51883.1 - 0.051 14.3 0.4 0.089 13.5 0.4 1.3 1 0 0 1 1 1 0 RecQ zinc-binding DZR PF12773.7 ORX51883.1 - 0.23 11.5 1.8 0.36 10.9 1.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon PI3_PI4_kinase PF00454.27 ORX51884.1 - 3.7e-54 184.2 0.0 8.7e-54 183.0 0.0 1.7 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase NUC194 PF08163.12 ORX51884.1 - 7.5e-32 110.7 0.3 3.9e-31 108.4 0.0 2.3 3 0 0 3 3 3 1 NUC194 domain FAT PF02259.23 ORX51884.1 - 1.7e-19 70.3 9.7 1.7e-19 70.3 9.7 1.9 2 0 0 2 2 2 1 FAT domain FATC PF02260.20 ORX51884.1 - 3.4e-11 42.8 0.5 1.3e-10 40.9 0.5 2.1 1 0 0 1 1 1 1 FATC domain RNase_P_Rpp14 PF01900.19 ORX51884.1 - 0.14 12.4 0.0 0.46 10.8 0.0 1.8 1 0 0 1 1 1 0 Rpp14/Pop5 family ParcG PF10274.9 ORX51885.1 - 0.01 15.9 0.1 0.11 12.6 0.0 2.6 3 0 0 3 3 3 0 Parkin co-regulated protein Sigma70_r1_1 PF03979.14 ORX51885.1 - 1.6 8.8 4.1 2.8 8.1 3.3 1.7 2 0 0 2 2 2 0 Sigma-70 factor, region 1.1 E1_DerP2_DerF2 PF02221.15 ORX51887.1 - 8e-24 84.6 0.4 9e-24 84.4 0.4 1.0 1 0 0 1 1 1 1 ML domain Y_Y_Y PF07495.13 ORX51887.1 - 0.011 15.7 0.0 0.034 14.1 0.0 1.7 1 1 0 2 2 2 0 Y_Y_Y domain DUF1091 PF06477.13 ORX51887.1 - 0.015 15.7 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) Wzt_C PF14524.6 ORX51887.1 - 0.022 14.8 0.0 2.9 7.9 0.0 2.5 1 1 2 3 3 3 0 Wzt C-terminal domain DUF4625 PF15418.6 ORX51887.1 - 0.16 12.2 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) CBS PF00571.28 ORX51888.1 - 0.012 16.0 0.3 0.018 15.5 0.3 1.4 1 1 0 1 1 1 0 CBS domain OrfB_Zn_ribbon PF07282.11 ORX51889.1 - 0.00025 20.9 0.1 0.00045 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Telomere_reg-2 PF10193.9 ORX51891.1 - 1.6e-23 83.2 1.9 6.1e-23 81.3 0.0 3.0 4 0 0 4 4 4 1 Telomere length regulation protein Imm52 PF15579.6 ORX51891.1 - 0.11 12.3 0.1 0.33 10.8 0.1 1.8 1 0 0 1 1 1 0 Immunity protein 52 DUF992 PF06186.11 ORX51894.1 - 0.025 14.4 0.1 0.044 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF992) Phage_T4_Ndd PF06591.11 ORX51894.1 - 0.097 12.5 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) ABC1 PF03109.16 ORX51895.1 - 1e-36 125.7 0.0 1.5e-36 125.1 0.0 1.3 1 0 0 1 1 1 1 ABC1 family DUF4283 PF14111.6 ORX51897.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) RRM_1 PF00076.22 ORX51898.1 - 5.9e-15 54.8 0.0 9.6e-15 54.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ORX51899.1 - 1.7e-18 66.2 0.0 2.4e-18 65.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ORX51899.1 - 0.094 12.7 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 RL domain RRM_occluded PF16842.5 ORX51899.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Ribonuc_L-PSP PF01042.21 ORX51900.1 - 1.9e-37 128.0 0.0 2.2e-37 127.8 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DUF4403 PF14356.6 ORX51900.1 - 0.019 13.6 0.0 0.023 13.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) Ala_racemase_N PF01168.20 ORX51901.1 - 8.6e-20 71.3 0.7 1.1e-19 71.0 0.7 1.1 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 ORX51901.1 - 2.6e-19 69.7 0.0 5e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Putative serine dehydratase domain Amidohydro_3 PF07969.11 ORX51902.1 - 4.4e-14 52.8 0.3 1.1e-06 28.4 0.1 3.0 2 1 0 3 3 3 2 Amidohydrolase family Amidohydro_1 PF01979.20 ORX51902.1 - 2e-09 37.2 1.3 9.7e-07 28.4 1.3 3.0 1 1 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ORX51902.1 - 0.03 14.6 0.2 0.068 13.5 0.2 1.6 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain Pantoate_transf PF02548.15 ORX51902.1 - 0.11 11.8 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase OrfB_Zn_ribbon PF07282.11 ORX51904.1 - 9.2e-10 38.3 0.2 3e-09 36.6 0.2 1.9 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX51904.1 - 0.0041 16.9 0.0 0.0066 16.2 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease EcoRII, N-terminal CN_hydrolase PF00795.22 ORX51906.1 - 5.4e-57 193.1 0.1 6.2e-57 192.9 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase HtrL_YibB PF09612.10 ORX51906.1 - 0.051 13.1 0.1 0.072 12.6 0.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (HtrL_YibB) Myb_DNA-binding PF00249.31 ORX51907.1 - 2.8e-17 62.6 0.2 9.2e-17 61.0 0.2 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX51907.1 - 8.8e-09 35.5 0.0 2.8e-08 33.9 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain Med9 PF07544.13 ORX51907.1 - 0.09 12.9 1.4 0.28 11.3 1.4 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 SLIDE PF09111.10 ORX51907.1 - 0.11 12.5 0.4 0.6 10.1 0.0 2.3 2 1 0 2 2 2 0 SLIDE ACOX PF01756.19 ORX51908.1 - 6.8e-33 113.7 0.2 2.8e-31 108.5 0.0 2.2 2 0 0 2 2 2 1 Acyl-CoA oxidase Acyl-CoA_ox_N PF14749.6 ORX51908.1 - 9.1e-18 65.0 0.1 2e-17 63.9 0.1 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_M PF02770.19 ORX51908.1 - 6.9e-15 55.0 0.3 1.3e-14 54.1 0.3 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX51908.1 - 0.12 13.0 0.0 0.43 11.2 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Gly_acyl_tr_C PF08444.10 ORX51909.1 - 0.015 15.5 0.6 0.041 14.1 0.0 2.0 3 0 0 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Z1 PF10593.9 ORX51909.1 - 0.079 12.4 1.4 0.093 12.2 0.7 1.5 1 1 0 1 1 1 0 Z1 domain Mg_trans_NIPA PF05653.14 ORX51910.1 - 7.2e-91 304.4 28.6 9.4e-91 304.0 28.6 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX51910.1 - 9.6e-07 29.0 7.0 9.6e-07 29.0 7.0 3.8 3 1 0 3 3 3 2 EamA-like transporter family FAM176 PF14851.6 ORX51910.1 - 0.2 11.3 0.0 0.48 10.1 0.0 1.6 1 0 0 1 1 1 0 FAM176 family Rod_C PF10493.9 ORX51911.1 - 0.21 9.9 0.0 0.24 9.8 0.0 1.0 1 0 0 1 1 1 0 Rough deal protein C-terminal region AWS PF17907.1 ORX51913.1 - 0.002 18.1 1.9 3.1 7.9 0.0 3.4 3 1 1 4 4 4 2 AWS domain ADAM_CR_2 PF17771.1 ORX51914.1 - 0.082 13.4 4.9 0.17 12.4 4.9 1.5 1 0 0 1 1 1 0 ADAM cysteine-rich domain Proteasome PF00227.26 ORX51916.1 - 2.4e-54 183.7 0.0 3.1e-54 183.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX51916.1 - 1.4e-12 47.1 0.0 3.2e-12 45.9 0.0 1.7 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature IGPD PF00475.18 ORX51916.1 - 0.095 13.0 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Imidazoleglycerol-phosphate dehydratase DnaJ PF00226.31 ORX51917.1 - 9.2e-07 28.9 0.0 1.4e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 ORX51917.1 - 0.0053 16.8 0.1 0.006 16.6 0.1 1.2 1 1 0 1 1 1 1 Pam16 zf-C2H2_2 PF12756.7 ORX51918.1 - 0.0011 19.3 1.0 0.0024 18.2 1.0 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Bot1p PF12298.8 ORX51918.1 - 0.073 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein DEAD PF00270.29 ORX51919.1 - 8e-47 159.3 0.1 1.1e-45 155.6 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX51919.1 - 2e-31 108.6 0.0 1.3e-30 106.0 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX51919.1 - 9.1e-06 25.8 0.0 2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ORX51919.1 - 0.018 14.7 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 ORX51919.1 - 0.042 14.1 0.2 0.16 12.2 0.2 2.0 1 1 0 1 1 1 0 AAA domain Peptidase_M24 PF00557.24 ORX51920.1 - 2.6e-22 79.5 0.1 3.5e-22 79.1 0.1 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 Fimbrial_CS1 PF04449.12 ORX51920.1 - 0.013 15.7 0.4 0.035 14.2 0.4 1.8 1 0 0 1 1 1 0 CS1 type fimbrial major subunit Atg29_N PF18388.1 ORX51921.1 - 9.5e-16 57.4 1.3 1.6e-15 56.6 1.3 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain MFS_1 PF07690.16 ORX51922.1 - 3.9e-36 124.7 22.6 4.9e-36 124.4 22.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 ORX51922.1 - 6.4e-06 25.7 8.9 6.4e-06 25.7 8.9 2.1 1 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Citrate_synt PF00285.21 ORX51923.1 - 2.9e-95 319.4 0.0 4.1e-95 318.9 0.0 1.2 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF3144 PF11342.8 ORX51923.1 - 0.081 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3144) Eclosion PF04736.12 ORX51923.1 - 0.14 11.8 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 Eclosion hormone SH3_1 PF00018.28 ORX51925.1 - 2.1e-11 43.2 0.5 5.5e-11 41.9 0.0 2.0 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ORX51925.1 - 3e-10 39.8 0.0 5.7e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX51925.1 - 6.3e-10 38.6 0.0 1.4e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Cyclin PF08613.11 ORX51926.1 - 2.7e-42 144.9 0.1 4.3e-42 144.2 0.1 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX51926.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Mitofilin PF09731.9 ORX51927.1 - 3e-76 257.6 28.9 1.8e-65 222.0 26.3 2.1 1 1 1 2 2 2 2 Mitochondrial inner membrane protein DUF5082 PF16888.5 ORX51927.1 - 0.02 15.1 5.0 1.1 9.6 1.6 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) Selenoprotein_S PF06936.11 ORX51927.1 - 0.93 9.3 7.3 2 8.2 6.8 1.8 1 1 0 1 1 1 0 Selenoprotein S (SelS) Apolipoprotein PF01442.18 ORX51927.1 - 5.1 6.9 35.2 47 3.8 30.2 3.3 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF924 PF06041.11 ORX51927.1 - 6.5 6.8 7.2 2.6 8.1 3.7 2.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF924) Phage_Mu_Gam PF07352.12 ORX51927.1 - 7 6.5 12.6 1.3 8.9 0.4 3.4 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein PIG-U PF06728.13 ORX51928.1 - 7.8e-109 364.2 34.6 1.1e-108 363.7 34.6 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U 8TM_micro PF17028.5 ORX51928.1 - 0.034 13.9 16.3 0.074 12.7 16.3 1.8 1 1 0 1 1 1 0 8TM Microsporidial transmembrane domain Dynamin_M PF01031.20 ORX51929.1 - 6.8e-100 333.9 1.4 1.5e-99 332.8 0.0 2.0 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ORX51929.1 - 2e-56 190.6 0.1 5.7e-56 189.2 0.0 1.9 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 ORX51929.1 - 5.1e-28 97.1 5.6 5.1e-28 97.1 5.6 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ORX51929.1 - 0.00032 20.8 1.2 0.00065 19.8 0.1 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ORX51929.1 - 0.11 12.9 0.0 0.37 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 ORX51929.1 - 0.13 11.9 4.4 3.6 7.2 0.1 3.1 3 0 0 3 3 3 0 AAA ATPase domain Acyltransferase PF01553.21 ORX51931.1 - 2.6e-15 56.2 0.0 5.2e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Ribosomal_S27e PF01667.17 ORX51932.1 - 8.9e-30 102.2 4.1 1.1e-29 101.9 4.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 ORX51932.1 - 0.00052 19.5 3.1 0.00079 18.9 3.1 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding IBR PF01485.21 ORX51932.1 - 0.017 15.4 0.6 0.024 14.8 0.6 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Prok-RING_1 PF14446.6 ORX51932.1 - 0.02 14.8 2.1 0.033 14.1 2.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C2HC5 PF06221.13 ORX51932.1 - 0.03 14.3 2.7 0.03 14.3 2.7 1.8 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zinc_ribbon_4 PF13717.6 ORX51932.1 - 0.057 13.3 1.9 1.9 8.5 1.9 2.3 1 1 0 1 1 1 0 zinc-ribbon domain TPR_1 PF00515.28 ORX51934.1 - 6.2e-31 104.9 6.7 6.9e-06 25.7 0.0 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ORX51934.1 - 1.6e-23 80.9 7.4 0.00031 20.6 0.0 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 ORX51934.1 - 1.2e-19 69.7 4.1 5.4e-07 29.2 0.0 4.1 4 1 1 5 5 4 3 TPR repeat TPR_12 PF13424.6 ORX51934.1 - 1.7e-17 63.4 4.6 4.3e-11 42.9 0.1 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX51934.1 - 5.6e-15 54.2 10.5 2e-05 24.4 0.1 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX51934.1 - 2.3e-11 42.9 2.6 0.00023 21.0 0.0 4.9 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX51934.1 - 9.1e-11 42.1 0.1 4.7e-05 23.8 0.1 3.4 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX51934.1 - 1.2e-09 38.7 0.4 0.026 15.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX51934.1 - 1.9e-09 37.5 0.3 0.96 10.4 0.0 5.1 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX51934.1 - 5.2e-08 32.5 2.5 0.077 12.9 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX51934.1 - 7.5e-08 32.5 5.1 0.00087 19.5 0.6 3.0 1 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ORX51934.1 - 9.6e-08 31.9 8.4 0.059 13.8 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX51934.1 - 6.1e-06 26.5 4.2 0.71 10.6 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_21 PF09976.9 ORX51934.1 - 0.00011 22.0 5.7 0.01 15.6 1.9 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 ORX51934.1 - 0.0034 17.5 0.2 0.23 11.6 0.0 2.8 1 1 2 3 3 3 1 Tetratricopeptide repeat PPR PF01535.20 ORX51934.1 - 0.0083 16.3 1.0 1.7 9.0 0.0 3.9 5 0 0 5 5 5 1 PPR repeat Clathrin_H_link PF13838.6 ORX51934.1 - 0.021 14.7 1.3 3 7.8 0.0 2.8 3 0 0 3 3 2 0 Clathrin-H-link MIT PF04212.18 ORX51934.1 - 0.067 13.3 7.3 11 6.2 0.0 4.6 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ORX51934.1 - 0.083 12.4 3.4 33 4.0 0.0 4.2 4 0 0 4 4 4 0 SHNi-TPR DUF2225 PF09986.9 ORX51934.1 - 0.11 12.2 8.0 0.49 10.1 1.2 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) RPN7 PF10602.9 ORX51934.1 - 0.14 11.9 3.5 0.5 10.1 0.0 2.9 1 1 2 3 3 3 0 26S proteasome subunit RPN7 SPO22 PF08631.10 ORX51934.1 - 0.57 9.6 5.0 6.8 6.1 0.0 3.4 2 2 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like FlaG PF03646.15 ORX51934.1 - 8 6.7 6.3 4 7.6 0.5 2.3 2 0 0 2 2 2 0 FlaG protein tRNA-synt_His PF13393.6 ORX51935.1 - 7.8e-39 133.8 0.1 9.3e-39 133.5 0.1 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ORX51935.1 - 9.9e-14 51.3 0.0 1.7e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 ORX51935.1 - 2.9e-05 23.7 0.0 4.6e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 ORX51935.1 - 0.0023 17.9 0.0 0.0054 16.7 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA-synt_2 PF00152.20 ORX51935.1 - 0.0065 15.6 0.4 0.12 11.4 0.3 2.7 2 1 0 2 2 2 1 tRNA synthetases class II (D, K and N) ABC_tran PF00005.27 ORX51936.1 - 8.9e-48 162.3 0.0 1.4e-23 83.9 0.0 3.8 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ORX51936.1 - 3.9e-15 56.5 0.4 1.4e-05 25.1 0.0 4.2 2 2 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX51936.1 - 1.6e-13 50.7 0.1 4.8e-05 22.9 0.0 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ORX51936.1 - 1.3e-07 31.7 1.0 0.0021 18.0 0.0 3.2 3 0 0 3 3 2 2 RsgA GTPase AAA_28 PF13521.6 ORX51936.1 - 2e-07 31.4 0.0 0.02 15.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX51936.1 - 3.2e-07 30.0 0.1 0.02 14.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX51936.1 - 1.2e-06 29.0 0.0 0.012 16.1 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain AAA PF00004.29 ORX51936.1 - 1.2e-06 29.0 0.0 0.046 14.1 0.0 4.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX51936.1 - 1.3e-06 28.5 0.0 0.015 15.4 0.0 3.2 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 ORX51936.1 - 1.5e-06 28.5 0.0 0.17 12.2 0.0 3.7 3 0 0 3 3 3 2 AAA domain AAA_15 PF13175.6 ORX51936.1 - 2.6e-06 27.4 2.5 0.015 15.0 0.0 2.7 3 0 0 3 3 2 2 AAA ATPase domain Chromo PF00385.24 ORX51936.1 - 6e-06 26.1 1.5 2.4e-05 24.1 0.3 2.5 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_18 PF13238.6 ORX51936.1 - 9.6e-06 26.2 0.0 0.2 12.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 ORX51936.1 - 1e-05 24.7 0.0 0.087 11.8 0.0 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 ORX51936.1 - 1.3e-05 25.5 0.0 0.33 11.4 0.0 2.8 2 0 0 2 2 2 2 RNA helicase AAA_23 PF13476.6 ORX51936.1 - 2.3e-05 25.0 7.9 0.026 15.0 0.0 3.5 3 1 0 3 3 3 2 AAA domain AAA_30 PF13604.6 ORX51936.1 - 6e-05 22.8 0.0 0.38 10.5 0.0 3.6 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ORX51936.1 - 0.00022 21.2 0.0 0.22 11.4 0.0 2.8 2 0 0 2 2 2 1 NACHT domain DUF87 PF01935.17 ORX51936.1 - 0.00031 20.9 0.2 0.41 10.7 0.0 3.5 3 0 0 3 3 3 1 Helicase HerA, central domain PduV-EutP PF10662.9 ORX51936.1 - 0.00031 20.5 0.0 0.44 10.3 0.0 3.2 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 ORX51936.1 - 0.00041 20.5 0.0 1.5 9.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain SbcCD_C PF13558.6 ORX51936.1 - 0.00041 20.5 0.4 0.54 10.5 0.0 3.9 3 2 0 3 3 3 1 Putative exonuclease SbcCD, C subunit DUF815 PF05673.13 ORX51936.1 - 0.00044 19.5 0.0 0.92 8.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) 4HB PF17947.1 ORX51936.1 - 0.00058 19.9 0.9 0.0025 17.8 0.0 2.6 3 0 0 3 3 1 1 Four helical bundle domain AAA_13 PF13166.6 ORX51936.1 - 0.0018 17.0 0.1 2.8 6.5 0.0 3.8 4 0 0 4 4 3 1 AAA domain CLP1_P PF16575.5 ORX51936.1 - 0.0019 18.0 0.0 0.18 11.6 0.0 2.8 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 ORX51936.1 - 0.0026 17.8 0.0 1.1 9.3 0.0 3.0 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 ORX51936.1 - 0.0033 17.4 0.0 2.3 8.1 0.0 2.4 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_27 PF13514.6 ORX51936.1 - 0.0063 16.1 0.0 3.2 7.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ORX51936.1 - 0.0077 15.5 0.0 1.1 8.4 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain AAA_24 PF13479.6 ORX51936.1 - 0.0087 15.8 0.3 0.82 9.4 0.0 3.0 3 0 0 3 3 3 1 AAA domain ATP-synt_ab PF00006.25 ORX51936.1 - 0.011 15.4 0.0 0.14 11.8 0.0 2.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Dynamin_N PF00350.23 ORX51936.1 - 0.013 15.6 0.0 1 9.4 0.0 2.8 2 0 0 2 2 2 0 Dynamin family IstB_IS21 PF01695.17 ORX51936.1 - 0.015 15.0 0.0 8 6.2 0.0 3.2 4 0 0 4 4 2 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 ORX51936.1 - 0.03 14.1 0.0 0.56 9.9 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase PRK PF00485.18 ORX51936.1 - 0.037 13.8 0.0 3.4 7.3 0.0 2.6 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 ORX51936.1 - 0.041 13.2 0.0 12 5.1 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 ORX51936.1 - 0.044 13.3 0.0 5.2 6.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region NTPase_1 PF03266.15 ORX51936.1 - 0.068 13.1 0.1 6.2 6.7 0.1 2.7 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 ORX51936.1 - 0.078 13.0 0.1 14 5.7 0.0 2.8 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ORX51936.1 - 0.11 12.5 0.0 23 5.0 0.0 3.0 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) FeoB_N PF02421.18 ORX51936.1 - 0.14 11.7 0.6 11 5.5 0.0 3.0 3 0 0 3 3 3 0 Ferrous iron transport protein B ATPase_2 PF01637.18 ORX51936.1 - 2.5 7.9 9.1 3.9 7.3 0.0 3.6 3 1 0 3 3 2 0 ATPase domain predominantly from Archaea HEAT PF02985.22 ORX51936.1 - 7.7 7.1 12.6 66 4.2 0.0 6.5 8 0 0 8 8 6 0 HEAT repeat BLOC1_2 PF10046.9 ORX51937.1 - 0.0016 18.7 3.6 0.0047 17.2 3.6 1.8 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 MAD PF05557.13 ORX51937.1 - 0.0029 16.1 2.8 0.0036 15.7 2.8 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein FapA PF03961.13 ORX51937.1 - 0.0034 16.1 0.1 0.004 15.8 0.1 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A PilJ PF13675.6 ORX51937.1 - 0.017 15.1 0.3 0.025 14.6 0.3 1.2 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Helo_like_N PF17111.5 ORX51937.1 - 0.02 14.2 0.3 0.024 14.0 0.3 1.2 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Cytochrom_B562 PF07361.11 ORX51937.1 - 0.02 15.5 2.2 0.027 15.1 2.2 1.2 1 0 0 1 1 1 0 Cytochrome b562 T2SSM PF04612.12 ORX51937.1 - 0.025 14.6 0.0 0.035 14.2 0.0 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M Phage_HK97_TLTM PF06120.11 ORX51937.1 - 0.03 13.5 0.2 0.038 13.2 0.2 1.1 1 0 0 1 1 1 0 Tail length tape measure protein UvrD_C PF13361.6 ORX51937.1 - 0.042 13.2 0.2 0.045 13.1 0.2 1.1 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain Phage_GP20 PF06810.11 ORX51937.1 - 0.044 13.6 4.4 0.07 12.9 4.4 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 Retrotrans_gag PF03732.17 ORX51937.1 - 0.061 13.6 1.1 0.16 12.3 0.9 1.8 2 1 0 2 2 2 0 Retrotransposon gag protein Jnk-SapK_ap_N PF09744.9 ORX51937.1 - 0.064 13.5 5.2 0.089 13.0 5.2 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0449 PF15136.6 ORX51937.1 - 4.4 7.8 7.0 23 5.5 7.0 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 DUF3808 PF10300.9 ORX51938.1 - 4.1e-67 227.0 0.9 7.5e-67 226.1 0.9 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX51938.1 - 0.0034 17.4 6.0 0.83 9.9 0.7 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX51938.1 - 0.0063 16.8 0.9 0.66 10.3 0.4 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 ORX51938.1 - 0.014 15.1 1.6 6.6 6.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 ORX51938.1 - 0.12 12.6 0.1 26 5.4 0.0 3.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_S8e PF01201.22 ORX51939.1 - 1e-43 148.8 0.1 1.4e-43 148.3 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Pup PF05639.11 ORX51939.1 - 0.075 13.9 1.7 0.14 13.1 1.7 1.4 1 0 0 1 1 1 0 Pup-like protein Chitin_synth_1 PF01644.17 ORX51940.1 - 2e-74 249.0 0.1 2.9e-74 248.5 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX51940.1 - 2.7e-29 100.9 0.1 6.6e-29 99.7 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX51940.1 - 6.5e-16 58.1 1.9 6.7e-15 54.7 0.0 2.5 3 0 0 3 3 3 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX51940.1 - 6.3e-07 29.5 0.4 6.3e-07 29.5 0.4 2.5 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Flp_N PF03930.14 ORX51941.1 - 0.28 11.2 1.3 0.92 9.5 0.4 2.1 1 1 1 2 2 2 0 Recombinase Flp protein N-terminus TP6A_N PF04406.14 ORX51942.1 - 4.4e-12 45.8 0.7 5.6e-12 45.5 0.7 1.2 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Aldo_ket_red PF00248.21 ORX51944.1 - 2.8e-73 246.7 0.0 3.2e-73 246.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MFS_1 PF07690.16 ORX51946.1 - 4.4e-16 58.7 71.4 9.4e-13 47.8 42.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily WD40 PF00400.32 ORX51948.1 - 3.1e-48 160.7 15.5 1e-06 29.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX51948.1 - 3e-12 46.7 2.4 0.0067 16.7 0.0 5.7 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX51948.1 - 0.0078 14.8 0.5 0.013 14.1 0.1 1.5 2 0 0 2 2 2 1 Cytochrome D1 heme domain Frtz PF11768.8 ORX51948.1 - 0.024 13.0 0.0 3.2 5.9 0.0 3.0 3 1 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Str_synth PF03088.16 ORX51948.1 - 0.049 13.8 0.0 7.5 6.8 0.0 2.7 1 1 1 2 2 2 0 Strictosidine synthase DUF4242 PF14026.6 ORX51948.1 - 0.099 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) WD40 PF00400.32 ORX51949.1 - 1.8e-39 133.0 37.1 4.2e-06 27.4 0.6 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ORX51949.1 - 6.7e-12 44.8 4.0 0.15 10.6 0.0 5.1 3 2 1 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ORX51949.1 - 1.2e-09 38.4 0.6 1.4 9.3 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX51949.1 - 9.4e-06 25.2 0.0 0.0034 16.8 0.0 2.7 1 1 1 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ORX51949.1 - 8.8e-05 22.5 0.1 16 5.6 0.0 4.8 3 2 2 5 5 5 2 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 ORX51949.1 - 0.00025 20.7 0.1 0.0045 16.6 0.1 2.3 1 1 0 1 1 1 1 PQQ-like domain PALB2_WD40 PF16756.5 ORX51949.1 - 0.001 18.1 2.9 5.4 5.8 0.1 4.4 2 1 3 5 5 5 2 Partner and localizer of BRCA2 WD40 domain DUF5046 PF16465.5 ORX51949.1 - 0.022 14.2 0.0 2 7.8 0.0 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF5046) Bromodomain PF00439.25 ORX51950.1 - 6.3e-46 154.4 1.5 1.4e-22 79.5 0.6 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 ORX51950.1 - 6.2e-22 77.5 0.1 1.6e-21 76.2 0.1 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation AHD PF17793.1 ORX51950.1 - 0.29 11.0 1.2 1.2 9.0 0.1 2.6 2 1 0 2 2 2 0 ANC1 homology domain (AHD) TMEM107 PF14995.6 ORX51951.1 - 0.013 15.9 0.1 0.016 15.6 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein MIS13 PF08202.11 ORX51952.1 - 0.00033 20.1 2.4 0.00039 19.8 2.4 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family AIP3 PF03915.13 ORX51952.1 - 0.00083 18.6 2.9 0.00097 18.3 2.9 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 DUF4665 PF15679.5 ORX51952.1 - 0.0078 16.8 2.9 0.0078 16.8 2.9 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4665) DUF4140 PF13600.6 ORX51952.1 - 0.014 15.8 4.5 2.2 8.7 0.1 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) zf-C4H2 PF10146.9 ORX51952.1 - 0.05 13.9 4.3 0.06 13.7 4.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein DUF4611 PF15387.6 ORX51952.1 - 0.053 13.7 0.3 0.088 13.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) G-gamma PF00631.22 ORX51952.1 - 0.074 13.1 0.1 0.074 13.1 0.1 1.8 2 0 0 2 2 2 0 GGL domain Seryl_tRNA_N PF02403.22 ORX51952.1 - 0.46 10.7 8.7 0.69 10.2 7.7 1.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spc24 PF08286.11 ORX51952.1 - 0.57 10.4 11.0 2.4 8.5 3.3 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlxA PF14282.6 ORX51952.1 - 1.7 8.6 12.1 1.7 8.7 6.4 2.2 1 1 1 2 2 2 0 FlxA-like protein SlyX PF04102.12 ORX51952.1 - 2.2 8.9 9.6 0.93 10.2 3.5 2.3 1 1 1 2 2 2 0 SlyX DUF4451 PF14616.6 ORX51953.1 - 6.1e-22 78.1 5.3 1.2e-21 77.2 5.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4451) Homeodomain PF00046.29 ORX51954.1 - 2.6e-15 56.0 4.2 4.1e-15 55.4 4.2 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX51954.1 - 0.0088 15.9 0.0 0.0088 15.9 0.0 2.1 2 1 0 2 2 2 1 Homeobox KN domain HTH_23 PF13384.6 ORX51954.1 - 0.023 14.5 0.0 0.075 12.8 0.0 1.8 1 1 1 2 2 2 0 Homeodomain-like domain PAC2 PF09754.9 ORX51955.1 - 6.6e-27 94.9 0.2 8.4e-27 94.6 0.2 1.1 1 0 0 1 1 1 1 PAC2 family IBV_3A PF03617.13 ORX51955.1 - 0.052 13.5 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 IBV 3A protein Zn_clus PF00172.18 ORX51958.1 - 0.00041 20.4 11.6 0.00086 19.4 11.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec7 PF01369.20 ORX51959.1 - 2.5e-71 239.2 1.0 1e-70 237.1 0.2 2.6 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 ORX51959.1 - 7.6e-44 149.4 2.1 7.6e-44 149.4 2.1 3.1 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 ORX51959.1 - 5.4e-35 119.1 13.2 1.1e-32 111.8 0.5 6.5 6 0 0 6 6 6 1 Domain of unknown function (DUF1981) DCB PF16213.5 ORX51959.1 - 5.4e-23 81.6 7.3 4.7e-22 78.5 5.7 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 EntA_Immun PF08951.10 ORX51959.1 - 0.086 13.2 1.8 0.68 10.3 1.8 2.7 1 0 0 1 1 1 0 Enterocin A Immunity PPR_2 PF13041.6 ORX51960.1 - 1.6e-05 25.0 0.1 0.28 11.4 0.0 5.5 4 1 1 5 5 5 2 PPR repeat family PPR_3 PF13812.6 ORX51960.1 - 0.0044 17.1 1.8 12 6.1 0.0 4.7 6 1 0 6 6 6 2 Pentatricopeptide repeat domain PPR PF01535.20 ORX51960.1 - 0.0095 16.1 0.1 72 4.0 0.0 5.4 5 1 1 6 6 6 0 PPR repeat PPR_long PF17177.4 ORX51960.1 - 0.013 14.8 0.1 3.6 6.9 0.0 2.6 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP TFR_dimer PF04253.15 ORX51960.1 - 0.077 13.1 0.0 0.3 11.2 0.0 2.0 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain RibD_C PF01872.17 ORX51961.1 - 3.8e-34 118.3 0.1 4.4e-34 118.1 0.1 1.0 1 0 0 1 1 1 1 RibD C-terminal domain SET PF00856.28 ORX51962.1 - 1.6e-10 41.6 0.0 3.4e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 SET domain Sugar_tr PF00083.24 ORX51963.1 - 4.9e-31 108.1 18.2 1.7e-22 80.0 1.2 2.2 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX51963.1 - 7.7e-09 34.9 15.3 7.7e-09 34.9 15.3 3.1 2 1 0 2 2 2 2 Major Facilitator Superfamily Isochorismatase PF00857.20 ORX51964.1 - 1.4e-19 70.9 0.1 4.5e-19 69.3 0.1 1.7 1 1 0 1 1 1 1 Isochorismatase family Pkinase PF00069.25 ORX51965.1 - 5.1e-59 199.8 0.0 5.8e-59 199.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51965.1 - 4.5e-29 101.5 0.0 5.4e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX51965.1 - 0.00036 20.5 0.0 0.0023 17.9 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX51965.1 - 0.0024 16.9 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX51965.1 - 0.0037 16.6 0.0 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX51965.1 - 0.019 14.4 0.4 0.1 11.9 0.1 2.3 2 1 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ORX51965.1 - 0.032 13.9 0.1 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 PurK_C PF17769.1 ORX51965.1 - 0.051 13.3 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylaminoimidazole carboxylase C-terminal domain RIO1 PF01163.22 ORX51965.1 - 0.053 13.1 0.0 0.1 12.2 0.0 1.4 1 1 0 1 1 1 0 RIO1 family Ribosomal_S5 PF00333.20 ORX51966.1 - 2.7e-29 100.9 0.3 7.9e-29 99.4 0.3 1.8 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ORX51966.1 - 1.1e-25 88.9 0.0 1.8e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 ORX51966.1 - 5.3 7.7 8.6 11 6.6 8.6 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 EF-hand_1 PF00036.32 ORX51967.1 - 1.9e-30 102.1 11.5 7.8e-08 31.3 1.5 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX51967.1 - 1.9e-26 92.3 12.5 1.9e-15 57.1 2.8 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ORX51967.1 - 5.5e-25 85.7 6.4 8.6e-09 34.5 0.0 4.2 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ORX51967.1 - 7.7e-24 81.5 8.1 7.1e-08 31.8 0.0 4.2 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ORX51967.1 - 4.1e-18 65.0 14.0 6.5e-11 41.9 0.7 4.1 2 2 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX51967.1 - 2.8e-08 34.0 4.8 7.8e-05 23.0 0.4 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ORX51967.1 - 8.3e-07 29.2 1.3 0.001 19.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX51967.1 - 9.2e-06 25.6 6.1 0.14 12.1 0.2 3.3 2 2 1 3 3 3 3 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ORX51967.1 - 0.00019 21.4 0.0 0.47 10.4 0.0 2.1 2 0 0 2 2 2 2 Tellurite resistance protein TerB Dockerin_1 PF00404.18 ORX51967.1 - 0.00031 20.9 5.5 0.32 11.2 0.4 3.8 3 1 1 4 4 4 3 Dockerin type I domain Caleosin PF05042.13 ORX51967.1 - 0.0082 16.1 0.2 5.2 7.0 0.1 2.6 2 1 0 2 2 2 2 Caleosin related protein EF-hand_11 PF08976.11 ORX51967.1 - 0.034 15.0 0.1 0.51 11.2 0.1 2.0 2 0 0 2 2 2 0 EF-hand domain EF-hand_10 PF14788.6 ORX51967.1 - 0.12 12.3 5.0 1.7 8.6 0.2 2.5 2 1 0 2 2 2 0 EF hand Claudin_2 PF13903.6 ORX51968.1 - 0.00011 22.1 7.5 0.00033 20.5 7.6 1.7 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Trp_oprn_chp PF09534.10 ORX51968.1 - 0.017 14.9 0.2 0.91 9.3 0.2 2.6 1 1 1 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF4131 PF13567.6 ORX51968.1 - 0.18 11.4 2.6 2.5 7.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) RNA_pol_L_2 PF13656.6 ORX51969.1 - 2.9e-30 103.9 0.0 3.5e-30 103.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ORX51969.1 - 2.8e-11 42.7 0.0 3.8e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain XPA_C PF05181.12 ORX51969.1 - 0.15 12.0 0.1 0.37 10.8 0.0 1.7 2 0 0 2 2 2 0 XPA protein C-terminus Glyco_transf_4 PF13439.6 ORX51970.1 - 0.0051 16.8 0.0 0.006 16.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_2 PF13477.6 ORX51970.1 - 0.03 14.3 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase 4-like Ole-e-6 PF09253.10 ORX51970.1 - 0.061 13.3 4.5 0.061 13.3 4.5 2.2 2 0 0 2 2 2 0 Pollen allergen ole e 6 RasGEF PF00617.19 ORX51971.1 - 3e-49 167.6 0.1 6.2e-49 166.6 0.1 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX51971.1 - 9.1e-17 61.2 1.0 2.6e-16 59.8 1.0 1.8 1 0 0 1 1 1 1 RasGEF N-terminal motif OST3_OST6 PF04756.13 ORX51972.1 - 2.2e-95 319.4 0.8 2.8e-95 319.1 0.8 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin PF00085.20 ORX51972.1 - 0.0011 18.9 0.0 0.0019 18.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin BofA PF07441.11 ORX51972.1 - 0.41 10.9 7.1 0.28 11.4 3.9 2.3 2 0 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA DUF2039 PF10217.9 ORX51973.1 - 1.7e-28 98.7 19.9 3.5e-28 97.8 19.9 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) zinc-ribbons_6 PF07191.12 ORX51973.1 - 2.2 8.3 14.6 5.3 7.1 14.6 1.6 1 1 0 1 1 1 0 zinc-ribbons Rsa3 PF14615.6 ORX51974.1 - 2.2e-16 59.1 0.1 3.6e-16 58.4 0.1 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 DUF2043 PF09740.9 ORX51975.1 - 2e-27 95.9 0.0 5.5e-27 94.5 0.0 1.8 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2043) Ribosomal_L10 PF00466.20 ORX51976.1 - 5e-12 45.8 0.0 8.3e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 Recep_L_domain PF01030.24 ORX51977.1 - 1.1e-11 44.8 0.5 0.0034 17.5 0.0 4.3 2 2 2 4 4 4 4 Receptor L domain LRR_4 PF12799.7 ORX51977.1 - 0.088 13.3 13.2 13 6.4 0.2 5.9 4 2 2 6 6 6 0 Leucine Rich repeats (2 copies) STAS_2 PF13466.6 ORX51977.1 - 0.1 13.0 0.2 0.63 10.4 0.0 2.5 2 1 0 2 2 2 0 STAS domain Utp11 PF03998.13 ORX51978.1 - 5.7e-77 259.0 26.1 6.5e-77 258.8 26.1 1.0 1 0 0 1 1 1 1 Utp11 protein WD40 PF00400.32 ORX51980.1 - 1.7e-08 35.0 18.9 0.00053 20.7 1.2 6.3 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX51980.1 - 4e-05 23.8 0.0 0.0015 18.8 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ORX51980.1 - 0.002 18.0 0.1 0.01 15.7 0.0 2.3 2 0 0 2 2 2 1 PQQ enzyme repeat BBS2_Mid PF14783.6 ORX51980.1 - 0.021 14.9 0.0 0.25 11.4 0.0 2.5 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 ORX51980.1 - 0.024 14.2 0.1 0.08 12.5 0.0 1.8 1 1 0 2 2 2 0 PQQ-like domain PQQ_3 PF13570.6 ORX51980.1 - 0.038 14.5 0.5 0.28 11.8 0.1 2.8 3 0 0 3 3 3 0 PQQ-like domain zf-RVT PF13966.6 ORX51981.1 - 0.00041 21.0 0.0 0.00072 20.2 0.0 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Cu-oxidase_3 PF07732.15 ORX51982.1 - 1.1e-31 109.3 1.6 1.1e-31 109.3 1.6 2.2 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase PF00394.22 ORX51982.1 - 9e-28 97.4 0.0 2.8e-27 95.8 0.0 1.8 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX51982.1 - 1.4e-20 73.4 11.3 2.9e-19 69.2 1.3 3.2 2 1 0 2 2 2 2 Multicopper oxidase GRP PF07172.11 ORX51982.1 - 0.77 10.5 22.3 2 9.1 22.3 1.6 1 0 0 1 1 1 0 Glycine rich protein family MFS_1 PF07690.16 ORX51983.1 - 1.6e-30 106.3 26.9 3.7e-29 101.8 26.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX51983.1 - 2.9e-06 26.8 20.0 1.9e-05 24.1 7.5 2.1 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB HigB-like_toxin PF05015.13 ORX51983.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB MFS_1 PF07690.16 ORX51984.1 - 5.7e-36 124.2 29.1 8.9e-36 123.5 29.1 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_4 PF06779.14 ORX51984.1 - 0.00026 20.4 6.9 0.00026 20.4 6.9 2.3 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Herpes_US9 PF06072.11 ORX51984.1 - 4.1 7.4 7.7 1.5 8.7 0.4 3.7 4 0 0 4 4 4 0 Alphaherpesvirus tegument protein US9 ubiquitin PF00240.23 ORX51985.1 - 5e-07 29.4 0.0 8.3e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD_2 PF13881.6 ORX51985.1 - 0.00029 20.9 0.0 0.00066 19.8 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX51985.1 - 0.00038 21.0 0.1 0.0012 19.3 0.0 1.8 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain TFIIA PF03153.13 ORX51985.1 - 0.36 10.8 10.7 0.71 9.8 10.7 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SNF2_N PF00176.23 ORX51986.1 - 8.1e-52 176.1 3.2 1.6e-51 175.1 3.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX51986.1 - 3.5e-21 75.6 0.1 1.7e-20 73.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX51986.1 - 9.9e-09 35.4 0.0 4.8e-08 33.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX51986.1 - 3.6e-08 32.9 0.1 1.1e-07 31.3 0.1 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SSURE PF11966.8 ORX51986.1 - 0.15 11.8 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 Fibronectin-binding repeat PB1 PF00564.24 ORX51987.1 - 2.3e-07 30.7 0.0 4.1e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 PB1 domain LSM PF01423.22 ORX51988.1 - 1.1e-18 66.7 0.2 1.6e-18 66.2 0.2 1.3 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX51988.1 - 0.029 14.0 0.1 0.063 12.9 0.1 1.6 1 0 0 1 1 1 0 Hfq protein Methyltransf_16 PF10294.9 ORX51989.1 - 6.5e-16 58.6 0.0 8.2e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ORX51989.1 - 6.1e-07 29.1 0.0 9.6e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX51989.1 - 1.9e-05 24.3 0.0 2.9e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX51989.1 - 5.1e-05 23.9 0.0 9.2e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX51989.1 - 0.00014 22.6 0.0 0.00023 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX51989.1 - 0.00068 19.5 0.0 0.00079 19.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX51989.1 - 0.0014 18.5 0.0 0.0031 17.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX51989.1 - 0.066 13.9 0.0 0.12 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX51989.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 HLH PF00010.26 ORX51990.1 - 4.1e-17 61.9 4.7 4.1e-17 61.9 4.7 2.0 2 1 1 3 3 3 1 Helix-loop-helix DNA-binding domain Macoilin PF09726.9 ORX51990.1 - 0.037 12.6 2.0 0.043 12.4 2.0 1.1 1 0 0 1 1 1 0 Macoilin family Fib_alpha PF08702.10 ORX51990.1 - 0.098 12.8 6.8 0.17 12.1 6.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MerR-DNA-bind PF09278.11 ORX51990.1 - 6.8 7.3 9.3 20 5.8 1.0 2.6 1 1 1 2 2 2 0 MerR, DNA binding Peptidase_M28 PF04389.17 ORX51991.1 - 3.5e-40 137.8 0.1 5.7e-40 137.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX51991.1 - 1e-07 31.9 0.1 1.8e-07 31.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 PA PF02225.22 ORX51991.1 - 1.9e-06 27.8 0.0 3.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M42 PF05343.14 ORX51991.1 - 4.6e-05 22.6 0.1 0.013 14.6 0.0 2.3 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase MOSC PF03473.17 ORX51992.1 - 7.7e-23 80.9 0.0 1.2e-22 80.3 0.0 1.3 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 ORX51992.1 - 5.6e-07 29.5 0.1 1.3e-06 28.3 0.1 1.6 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain Ubie_methyltran PF01209.18 ORX51993.1 - 2.8e-82 275.5 0.1 3.5e-82 275.2 0.1 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX51993.1 - 3.3e-17 62.9 0.0 7.5e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX51993.1 - 1.1e-16 61.4 0.0 2.4e-16 60.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX51993.1 - 1.1e-11 44.9 0.0 3.1e-11 43.4 0.0 1.6 1 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX51993.1 - 1.6e-11 44.3 0.0 3.5e-11 43.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX51993.1 - 5.6e-11 43.1 0.1 2e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_28 PF02636.17 ORX51993.1 - 0.00037 20.2 0.0 0.00059 19.6 0.0 1.2 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 ORX51993.1 - 0.0021 17.6 0.0 0.0058 16.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ORX51993.1 - 0.0031 17.4 0.0 0.0074 16.2 0.0 1.7 1 0 0 1 1 1 1 Hypothetical methyltransferase ADH_zinc_N PF00107.26 ORX51993.1 - 0.007 16.4 0.0 0.017 15.1 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Pkinase PF00069.25 ORX51995.1 - 2.4e-75 253.3 0.0 3.8e-75 252.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX51995.1 - 8e-40 136.7 0.0 1.2e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX51995.1 - 1.7e-05 24.9 0.1 0.00056 19.9 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX51995.1 - 0.01 15.1 0.0 0.084 12.2 0.0 2.0 2 0 0 2 2 2 0 Kinase-like Choline_kinase PF01633.20 ORX51995.1 - 0.019 14.5 0.1 0.037 13.6 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF1676 PF07898.13 ORX51995.1 - 0.092 12.8 0.3 0.19 11.8 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Haspin_kinase PF12330.8 ORX51995.1 - 0.11 11.4 0.1 0.11 11.4 0.1 2.0 2 0 0 2 2 2 0 Haspin like kinase domain LAG1-DNAbind PF09271.11 ORX51996.1 - 4.9e-37 127.9 0.0 1.4e-36 126.4 0.0 1.9 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ORX51996.1 - 1.5e-19 70.7 0.1 1.2e-11 45.1 0.0 3.3 2 1 0 2 2 2 2 Beta-trefoil DNA-binding domain Melibiase PF02065.18 ORX51998.1 - 1.7e-17 63.4 0.1 2.6e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_31 PF01055.26 ORX51998.1 - 1.2e-06 28.0 0.2 2.3e-06 27.1 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Raffinose_syn PF05691.12 ORX51998.1 - 0.0032 15.4 0.1 0.0043 14.9 0.1 1.1 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 Melibiase_2 PF16499.5 ORX51998.1 - 0.1 11.7 0.1 0.58 9.3 0.0 2.2 3 0 0 3 3 3 0 Alpha galactosidase A FYRN PF05964.14 ORX51999.1 - 5.1e-20 71.1 0.4 5.1e-20 71.1 0.4 1.8 2 0 0 2 2 2 1 F/Y-rich N-terminus FYRC PF05965.14 ORX51999.1 - 7.6e-13 48.4 0.0 1.9e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 F/Y rich C-terminus HSP70 PF00012.20 ORX52000.1 - 3e-261 867.9 8.4 3.4e-261 867.7 8.4 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX52000.1 - 2.6e-18 65.9 0.0 5.5e-16 58.3 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Gp-FAR-1 PF05823.12 ORX52000.1 - 0.0034 17.7 2.4 0.0034 17.7 2.4 2.2 2 0 0 2 2 2 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Hydantoinase_A PF01968.18 ORX52000.1 - 0.012 14.9 0.1 0.029 13.6 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase FtsA PF14450.6 ORX52000.1 - 0.021 15.2 2.9 8.5 6.9 0.2 3.5 3 2 0 3 3 3 0 Cell division protein FtsA FGGY_C PF02782.16 ORX52000.1 - 0.025 14.3 0.0 0.15 11.7 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain OmpH PF03938.14 ORX52000.1 - 0.1 12.9 9.4 4.7 7.6 9.0 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TetR_C_25 PF17933.1 ORX52000.1 - 0.13 12.6 1.0 0.54 10.6 0.1 2.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF4795 PF16043.5 ORX52000.1 - 0.14 11.7 6.5 0.58 9.7 4.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4795) MutS_III PF05192.18 ORX52000.1 - 0.63 10.2 6.6 1.3 9.2 1.3 2.6 2 1 0 2 2 2 0 MutS domain III MnmE_helical PF12631.7 ORX52000.1 - 1.2 9.2 5.6 1.8 8.7 0.0 2.5 1 1 0 2 2 2 0 MnmE helical domain Aminotran_1_2 PF00155.21 ORX52001.1 - 1.4e-38 133.0 0.0 2.3e-38 132.3 0.0 1.3 2 0 0 2 2 2 1 Aminotransferase class I and II Lzipper-MIP1 PF14389.6 ORX52002.1 - 0.01 16.1 2.2 0.032 14.5 2.2 1.8 1 0 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 Goodbye PF17109.5 ORX52002.1 - 0.53 10.7 1.7 0.94 9.9 0.1 2.0 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain DcpS_C PF11969.8 ORX52003.1 - 1.3e-29 102.9 0.5 1.3e-29 102.9 0.5 1.6 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 ORX52003.1 - 4.6e-21 75.6 0.1 9.7e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal FA_hydroxylase PF04116.13 ORX52004.1 - 2.9e-24 85.9 23.8 2.9e-24 85.9 23.8 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily MMS19_C PF12460.8 ORX52005.1 - 6e-69 233.2 23.8 1.4e-68 232.0 7.7 4.6 2 2 2 5 5 5 2 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 ORX52005.1 - 3.3e-65 220.3 0.2 3.3e-65 220.3 0.2 3.6 5 0 0 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 ORX52005.1 - 0.0028 18.1 5.3 0.084 13.4 0.3 5.6 6 1 1 7 7 7 1 HEAT-like repeat HEAT_2 PF13646.6 ORX52005.1 - 0.0095 16.3 1.1 0.21 12.0 0.3 3.6 3 0 0 3 3 3 1 HEAT repeats DUF3819 PF12842.7 ORX52005.1 - 0.033 14.1 0.1 0.17 11.8 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) HEAT PF02985.22 ORX52005.1 - 0.072 13.4 0.1 7.3 7.1 0.0 4.0 3 0 0 3 3 3 0 HEAT repeat RTP1_C1 PF10363.9 ORX52005.1 - 0.18 12.0 2.7 39 4.5 0.0 4.6 3 2 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Pox_E2-like PF04497.12 ORX52006.1 - 0.028 12.9 0.2 0.027 13.0 0.2 1.2 1 0 0 1 1 1 0 Poxviridae protein Velvet PF11754.8 ORX52007.1 - 1.6e-36 126.5 5.1 8.3e-23 81.6 0.5 3.4 2 2 1 3 3 3 2 Velvet factor UPF0047 PF01894.17 ORX52008.1 - 2.2e-33 114.8 0.0 2.6e-33 114.6 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 PDZ_5 PF17817.1 ORX52009.1 - 0.0052 17.0 0.7 0.02 15.2 0.1 2.1 2 1 0 2 2 2 1 PDZ domain CotH PF08757.11 ORX52010.1 - 1.4e-32 113.5 0.0 1.9e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 CotH kinase protein AGTRAP PF06396.11 ORX52011.1 - 3.8e-11 43.0 0.0 4.7e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Angiotensin II, type I receptor-associated protein (AGTRAP) LRR_6 PF13516.6 ORX52012.1 - 0.0051 16.8 24.9 0.12 12.5 0.3 8.4 8 1 0 8 8 8 3 Leucine Rich repeat PH PF00169.29 ORX52012.1 - 0.0073 16.8 0.0 0.023 15.2 0.0 1.9 1 1 0 1 1 1 1 PH domain LRR_4 PF12799.7 ORX52012.1 - 0.43 11.1 6.3 11 6.6 0.1 5.6 7 0 0 7 7 7 0 Leucine Rich repeats (2 copies) zf-AN1 PF01428.16 ORX52013.1 - 8.6e-21 73.8 27.8 1.2e-12 47.8 1.7 3.7 3 1 1 4 4 4 2 AN1-like Zinc finger zf-WRNIP1_ubi PF18279.1 ORX52013.1 - 0.68 10.7 8.7 20 6.1 0.4 4.4 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Ribosomal_L28 PF00830.19 ORX52014.1 - 4.1e-22 78.1 0.5 5.7e-22 77.7 0.5 1.2 1 0 0 1 1 1 1 Ribosomal L28 family F-box-like PF12937.7 ORX52015.1 - 0.00023 21.0 1.9 0.00023 21.0 1.9 3.3 4 0 0 4 4 4 1 F-box-like F-box PF00646.33 ORX52015.1 - 0.01 15.7 0.3 0.01 15.7 0.3 2.8 2 0 0 2 2 2 0 F-box domain Cyclin_N PF00134.23 ORX52016.1 - 1e-09 38.2 0.4 1.4e-09 37.7 0.4 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX52016.1 - 1.4e-07 32.1 0.3 2e-05 25.0 0.1 2.2 2 0 0 2 2 2 2 Cyclin TIG PF01833.24 ORX52017.1 - 1.8e-11 43.9 0.1 5.8e-11 42.3 0.1 1.9 1 0 0 1 1 1 1 IPT/TIG domain Cyclin PF08613.11 ORX52018.1 - 0.021 15.2 0.1 0.04 14.3 0.1 1.5 1 0 0 1 1 1 0 Cyclin SRP40_C PF05022.12 ORX52019.1 - 7.4e-30 103.6 2.9 3.3e-29 101.5 2.9 2.2 1 0 0 1 1 1 1 SRP40, C-terminal domain LisH PF08513.11 ORX52019.1 - 0.0026 17.6 0.0 0.0042 17.0 0.0 1.3 1 0 0 1 1 1 1 LisH zf-CCCH_4 PF18044.1 ORX52020.1 - 2.9e-15 55.7 9.6 1.8e-07 30.8 1.7 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 ORX52020.1 - 2.8e-12 46.2 7.5 4.2e-06 26.5 1.3 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX52020.1 - 2.5e-10 40.1 19.9 1.7e-06 27.9 4.4 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 ORX52020.1 - 5.8e-08 33.4 7.2 0.0024 18.6 0.9 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 ORX52020.1 - 7.5e-06 26.1 1.3 1.5e-05 25.2 1.3 1.4 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 ORX52020.1 - 0.014 15.9 3.4 0.014 15.9 3.4 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger SWI-SNF_Ssr4 PF08549.10 ORX52020.1 - 4.8 5.7 10.7 0.19 10.3 4.5 1.7 1 1 1 2 2 2 0 Fungal domain of unknown function (DUF1750) DUF5054 PF16477.5 ORX52021.1 - 0.083 12.7 0.0 0.086 12.6 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5054) FtsX_ECD PF18075.1 ORX52022.1 - 0.0043 17.7 0.8 0.21 12.2 0.2 2.7 2 1 0 2 2 2 1 FtsX extracellular domain DUF5612 PF18462.1 ORX52022.1 - 0.026 14.3 0.0 2.7 7.8 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5612) DUF3213 PF11491.8 ORX52022.1 - 0.066 13.4 0.1 14 6.0 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3213) Abhydrolase_1 PF00561.20 ORX52023.1 - 7.7e-46 156.8 0.1 2.1e-44 152.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 ORX52023.1 - 0.0011 18.7 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ORX52023.1 - 0.0039 16.5 0.1 0.15 11.3 0.1 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Swi5 PF07061.11 ORX52024.1 - 0.00015 21.8 2.0 0.00018 21.6 2.0 1.1 1 0 0 1 1 1 1 Swi5 GAS PF13851.6 ORX52024.1 - 0.0092 15.4 3.1 0.011 15.1 3.1 1.0 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding TraF PF13728.6 ORX52024.1 - 0.028 14.2 0.8 0.03 14.2 0.8 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein TMF_DNA_bd PF12329.8 ORX52024.1 - 0.06 13.4 3.3 0.068 13.2 3.3 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Nre_N PF04894.12 ORX52024.1 - 0.082 12.7 0.1 0.086 12.7 0.1 1.0 1 0 0 1 1 1 0 Archaeal Nre, N-terminal TSNAXIP1_N PF15739.5 ORX52024.1 - 0.085 13.2 3.6 0.1 13.0 3.6 1.1 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DUF4552 PF15089.6 ORX52025.1 - 0.017 14.2 1.7 0.021 13.9 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) GRDP-like PF07173.12 ORX52026.1 - 2.4e-14 54.2 3.1 2.4e-14 54.2 3.1 1.9 2 0 0 2 2 2 1 Glycine-rich domain-containing protein-like Ribosomal_L26 PF16906.5 ORX52027.1 - 1.9e-38 130.8 3.8 1.9e-38 130.8 3.8 1.4 2 0 0 2 2 2 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ORX52027.1 - 1.1e-09 37.9 4.6 2.3e-09 36.8 4.6 1.6 1 0 0 1 1 1 1 KOW motif DUF5301 PF17225.3 ORX52027.1 - 0.036 14.5 0.0 0.05 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) TFIIF_alpha PF05793.12 ORX52028.1 - 3e-23 82.2 43.9 3e-23 82.2 43.9 2.5 2 1 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AMP-binding PF00501.28 ORX52029.1 - 5.9e-88 295.3 0.0 9.3e-88 294.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX52029.1 - 6.8e-06 27.0 0.0 2.8e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Glyco_transf_88 PF16849.5 ORX52029.1 - 0.0091 15.0 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 88 DUF3572 PF12096.8 ORX52029.1 - 0.02 15.1 0.1 0.13 12.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3572) TFIID-18kDa PF02269.16 ORX52030.1 - 1.3e-22 79.7 0.2 2e-22 79.0 0.2 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Spt20 PF12090.8 ORX52030.1 - 0.0043 16.7 3.6 0.0045 16.6 3.6 1.2 1 0 0 1 1 1 1 Spt20 family AIM3 PF17096.5 ORX52030.1 - 0.027 15.4 3.4 0.029 15.3 3.4 1.2 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 DUF4127 PF13552.6 ORX52030.1 - 0.11 11.1 2.0 0.13 10.8 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) Aquarius_N PF16399.5 ORX52031.1 - 2.4e-289 961.9 7.7 3.1e-289 961.6 7.7 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 ORX52031.1 - 9.2e-29 101.0 2.3 1.5e-28 100.3 0.0 2.4 2 1 0 2 2 1 1 AAA domain AAA_12 PF13087.6 ORX52031.1 - 2.7e-28 99.0 0.0 5.1e-28 98.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX52031.1 - 3e-10 40.6 0.0 1.7e-09 38.2 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX52031.1 - 6.2e-08 32.6 0.0 0.0053 16.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 ORX52031.1 - 3.2e-05 24.0 0.0 9.5e-05 22.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX52031.1 - 0.00016 21.5 0.0 0.00044 20.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 ORX52031.1 - 0.00085 18.9 0.0 0.00085 18.9 0.0 3.2 4 1 0 4 4 4 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 ORX52031.1 - 0.0051 16.6 0.1 0.0098 15.7 0.1 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 ORX52031.1 - 0.0051 16.1 0.7 0.017 14.3 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 ORX52031.1 - 0.01 15.3 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_22 PF13401.6 ORX52031.1 - 0.014 15.6 0.0 0.1 12.9 0.0 2.5 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX52031.1 - 0.034 14.6 0.0 0.12 12.7 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ORX52031.1 - 0.05 13.3 0.1 6.8 6.4 0.0 3.2 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 ORX52031.1 - 0.054 13.1 0.0 0.19 11.3 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX52031.1 - 0.073 13.5 0.2 0.61 10.5 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain CRS1_YhbY PF01985.21 ORX52031.1 - 0.14 12.3 0.1 0.44 10.8 0.1 1.8 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain AAA_23 PF13476.6 ORX52031.1 - 4 7.9 5.5 48 4.4 0.0 3.3 3 0 0 3 3 3 0 AAA domain UvrD_C PF13361.6 ORX52031.1 - 9.2 5.5 7.6 1.1e+02 2.0 0.0 4.5 5 0 0 5 5 5 0 UvrD-like helicase C-terminal domain BTB_2 PF02214.22 ORX52032.1 - 0.0038 17.6 0.0 3 8.3 0.0 2.9 3 0 0 3 3 3 2 BTB/POZ domain TIP41 PF04176.13 ORX52033.1 - 1.7e-61 206.6 0.9 2.9e-61 205.9 0.9 1.3 1 0 0 1 1 1 1 TIP41-like family ATE_C PF04377.15 ORX52034.1 - 1.9e-50 171.0 5.3 3.9e-50 170.0 5.3 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 ORX52034.1 - 6.2e-28 97.0 2.0 1.5e-27 95.8 2.0 1.7 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus LIM PF00412.22 ORX52037.1 - 3.1e-52 174.6 37.0 1.6e-16 60.2 2.2 4.2 4 0 0 4 4 4 4 LIM domain VATC PF18716.1 ORX52037.1 - 0.0012 18.7 2.0 0.0012 18.7 2.0 5.7 6 1 0 6 6 6 1 Vms1-associating treble clef domain OrfB_Zn_ribbon PF07282.11 ORX52037.1 - 0.0076 16.1 0.9 0.0076 16.1 0.9 3.6 4 1 1 5 5 5 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX52037.1 - 0.07 13.2 38.3 1.1 9.3 8.9 6.2 2 2 1 3 3 3 0 Double zinc ribbon DUF3725 PF12523.8 ORX52037.1 - 1.1 9.6 9.3 2.4 8.5 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3725) Kinesin PF00225.23 ORX52039.1 - 5.6e-89 298.4 0.0 1.2e-88 297.2 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX52039.1 - 4.9e-14 52.5 0.0 1.6e-11 44.3 0.0 2.7 1 1 1 2 2 2 2 Microtubule binding Bestrophin PF01062.21 ORX52039.1 - 0.16 11.3 1.4 0.21 10.9 0.4 1.8 2 0 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel Pex2_Pex12 PF04757.14 ORX52040.1 - 1.5e-28 100.0 4.7 2e-28 99.5 4.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region Pyrophosphatase PF00719.19 ORX52041.1 - 1.1e-57 194.3 0.2 1.4e-57 193.9 0.2 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Elongin_A PF06881.11 ORX52041.1 - 0.068 13.7 0.8 0.18 12.3 0.3 1.8 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A SH3_9 PF14604.6 ORX52042.1 - 9.7e-10 38.2 0.1 2.1e-09 37.1 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ORX52042.1 - 2.8e-08 33.2 0.0 5.5e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX52042.1 - 3.4e-06 26.7 0.0 8.6e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain Homeodomain PF00046.29 ORX52043.1 - 4.3e-16 58.5 1.6 7e-16 57.8 1.6 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX52043.1 - 0.0034 17.2 0.5 0.0095 15.8 0.1 2.0 2 0 0 2 2 2 1 Homeobox KN domain Glyco_transf_22 PF03901.17 ORX52044.1 - 4.5e-41 141.5 22.8 5.4e-41 141.2 22.8 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family PMT_2 PF13231.6 ORX52044.1 - 0.0018 18.5 10.9 0.0018 18.5 10.9 2.6 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase RseC_MucC PF04246.12 ORX52044.1 - 0.31 11.0 2.8 0.6 10.1 0.1 2.5 2 1 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Arrestin_C PF02752.22 ORX52045.1 - 4.8e-06 27.0 2.1 0.00047 20.6 0.4 2.7 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX52045.1 - 7.5e-05 22.8 0.0 0.0011 19.0 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Pkinase PF00069.25 ORX52046.1 - 1.4e-70 237.7 0.0 2.1e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52046.1 - 4.4e-52 176.9 0.0 5.9e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX52046.1 - 0.0003 20.2 0.0 0.0096 15.3 0.0 2.3 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ORX52046.1 - 0.00051 19.7 0.1 0.001 18.7 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX52046.1 - 0.0034 16.2 0.0 0.0058 15.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX52046.1 - 0.021 14.4 0.1 0.021 14.4 0.1 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kdo PF06293.14 ORX52046.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PIP49_C PF12260.8 ORX52046.1 - 0.18 11.4 0.0 0.31 10.6 0.0 1.4 1 1 0 1 1 1 0 Protein-kinase domain of FAM69 Paf67 PF10255.9 ORX52047.1 - 8.3e-171 568.4 5.3 1e-170 568.2 5.3 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 ORX52047.1 - 9.4e-05 22.2 0.1 0.0078 16.3 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX52047.1 - 0.0011 18.6 0.0 0.017 14.9 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX52047.1 - 0.0031 17.8 0.1 0.98 9.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat Tudor_2 PF18104.1 ORX52047.1 - 5.4 6.8 7.1 8.1 6.2 0.0 2.8 3 0 0 3 3 3 0 Jumonji domain-containing protein 2A Tudor domain V-ATPase_C PF03223.15 ORX52048.1 - 3.9e-126 421.4 6.3 4.3e-126 421.3 6.3 1.0 1 0 0 1 1 1 1 V-ATPase subunit C HrpB2 PF09487.10 ORX52048.1 - 0.028 14.8 1.8 0.054 13.9 1.8 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB2) p450 PF00067.22 ORX52049.1 - 2.2e-56 191.5 0.0 3e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 VPS13 PF16908.5 ORX52050.1 - 1.3e-74 251.0 3.1 1.3e-70 237.9 0.1 4.1 4 1 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 ORX52050.1 - 3.7e-71 239.3 3.5 8.2e-71 238.2 1.0 2.9 2 0 0 2 2 2 1 Repeating coiled region of VPS13 VPS13_C PF16909.5 ORX52050.1 - 9.6e-67 224.2 8.8 2.1e-65 219.8 0.1 3.0 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ORX52050.1 - 1.9e-60 204.6 1.6 2.4e-59 201.0 0.1 2.5 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 Chorein_N PF12624.7 ORX52050.1 - 9.8e-39 132.1 2.1 3.3e-38 130.4 2.1 2.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 ORX52050.1 - 1.2e-07 32.0 0.0 3.7e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Hexokinase_2 PF03727.16 ORX52051.1 - 2.3e-68 230.2 0.0 2.9e-68 229.9 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX52051.1 - 5.7e-57 192.8 0.0 8.6e-57 192.3 0.0 1.3 1 0 0 1 1 1 1 Hexokinase RRM_1 PF00076.22 ORX52053.1 - 1.3e-24 85.8 0.0 2.5e-11 43.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PseudoU_synth_2 PF00849.22 ORX52054.1 - 1.9e-28 99.6 0.0 3.3e-28 98.8 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase VHS PF00790.19 ORX52055.1 - 2.4e-29 102.0 0.0 4.3e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 ORX52055.1 - 2.8e-16 58.8 0.1 5.5e-16 57.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX52055.1 - 1.8e-14 53.3 0.1 4e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX52055.1 - 3.7e-12 45.7 0.1 2e-11 43.4 0.2 2.0 2 0 0 2 2 2 1 Variant SH3 domain GAT PF03127.14 ORX52055.1 - 9.7e-12 45.0 1.9 2.9e-11 43.5 1.9 1.9 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 ORX52055.1 - 0.0086 15.9 2.5 0.0086 15.9 2.5 2.5 2 0 0 2 2 2 1 Ubiquitin interaction motif Pheromone PF08015.11 ORX52055.1 - 1.8 9.6 7.1 9.2 7.4 7.1 2.3 1 0 0 1 1 1 0 Fungal mating-type pheromone Trypsin PF00089.26 ORX52056.1 - 2.9e-20 73.1 0.0 4e-20 72.6 0.0 1.1 1 0 0 1 1 1 1 Trypsin Trypsin_2 PF13365.6 ORX52056.1 - 1.2e-05 26.3 0.0 1.7e-05 25.7 0.0 1.2 1 0 0 1 1 1 1 Trypsin-like peptidase domain Cullin PF00888.22 ORX52057.1 - 3.5e-139 465.3 4.6 4.2e-139 465.0 4.6 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX52057.1 - 3.9e-18 65.2 0.0 1.2e-17 63.7 0.0 1.9 1 0 0 1 1 1 1 Cullin protein neddylation domain DUF4441 PF14536.6 ORX52057.1 - 0.056 13.6 0.1 0.27 11.4 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4441) DUF4423 PF14394.6 ORX52057.1 - 0.058 13.1 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Cation_efflux PF01545.21 ORX52058.1 - 1.3e-12 47.9 7.0 1.9e-12 47.4 7.0 1.3 1 0 0 1 1 1 1 Cation efflux family SPX PF03105.19 ORX52058.1 - 0.011 15.7 1.5 0.014 15.3 1.5 1.3 1 0 0 1 1 1 0 SPX domain DUF5134 PF17197.4 ORX52058.1 - 0.055 13.4 0.1 0.055 13.4 0.1 4.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5134) Hydrolase_4 PF12146.8 ORX52059.1 - 1.9e-13 50.2 0.0 8.7e-08 31.7 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX52059.1 - 1.9e-08 34.3 0.0 5.3e-05 23.0 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold DLH PF01738.18 ORX52059.1 - 6.4e-07 29.1 0.0 2.4e-06 27.2 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ORX52059.1 - 1.7e-06 28.1 0.0 0.0014 18.6 0.0 2.2 1 1 0 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 ORX52059.1 - 0.00056 19.5 0.0 0.0047 16.4 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ORX52059.1 - 0.0013 18.6 0.0 0.056 13.2 0.0 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 ORX52059.1 - 0.0066 16.1 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 ORX52059.1 - 0.045 12.4 0.0 0.33 9.6 0.0 2.2 2 1 0 2 2 2 0 Acetyl xylan esterase (AXE1) Abhydrolase_6 PF12697.7 ORX52059.1 - 0.058 14.0 0.0 0.63 10.6 0.0 2.0 1 1 1 2 2 2 0 Alpha/beta hydrolase family DUF818 PF05677.12 ORX52059.1 - 0.059 12.3 0.0 0.088 11.7 0.0 1.2 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) Esterase PF00756.20 ORX52059.1 - 0.19 11.3 0.0 0.43 10.2 0.0 1.6 1 1 0 1 1 1 0 Putative esterase Vac7 PF12751.7 ORX52060.1 - 1.6e-17 64.0 13.2 1.9e-13 50.6 0.2 3.2 1 1 2 3 3 3 3 Vacuolar segregation subunit 7 adh_short PF00106.25 ORX52061.1 - 6.1e-09 35.6 0.1 1.3e-08 34.5 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX52061.1 - 4.8e-08 32.8 0.0 6.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ORX52061.1 - 5.9e-05 22.6 0.3 0.0013 18.3 0.3 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Band_7 PF01145.25 ORX52062.1 - 3.7e-23 82.4 4.3 5.9e-23 81.8 4.3 1.4 1 0 0 1 1 1 1 SPFH domain / Band 7 family Sel1 PF08238.12 ORX52063.1 - 1.6e-29 101.7 31.3 3.2e-05 24.5 0.1 11.3 11 0 0 11 11 11 7 Sel1 repeat TPR_7 PF13176.6 ORX52063.1 - 0.006 16.5 3.2 0.18 11.9 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat Transpeptidase PF00905.22 ORX52063.1 - 0.013 14.7 0.0 0.032 13.5 0.0 1.6 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain DUF4144 PF13642.6 ORX52063.1 - 0.096 13.3 0.0 0.44 11.1 0.0 2.1 2 0 0 2 2 2 0 protein structure with unknown function TPR_8 PF13181.6 ORX52063.1 - 0.14 12.4 4.9 0.52 10.7 0.6 4.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX52063.1 - 0.26 11.8 10.2 1.1 9.8 0.1 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX52063.1 - 0.33 11.3 7.4 0.73 10.2 0.1 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX52063.1 - 0.35 11.6 16.8 8.1 7.3 0.0 5.9 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX52063.1 - 0.63 10.7 9.7 0.46 11.2 0.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat SNAP PF14938.6 ORX52063.1 - 2.8 7.3 8.5 1.5 8.2 0.1 3.5 3 1 1 4 4 4 0 Soluble NSF attachment protein, SNAP Uds1 PF15456.6 ORX52064.1 - 1.8e-12 47.6 10.3 1.8e-12 47.6 10.3 8.1 5 3 2 7 7 7 2 Up-regulated During Septation DUF2935 PF11155.8 ORX52064.1 - 0.054 13.8 13.3 0.41 11.0 1.0 4.7 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Homeodomain PF00046.29 ORX52064.1 - 0.066 13.1 3.0 0.36 10.7 0.4 3.4 2 0 0 2 2 2 0 Homeodomain DUF3800 PF12686.7 ORX52064.1 - 2.6 8.7 7.4 1.5e+03 -0.2 7.4 4.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Cnd1 PF12717.7 ORX52277.1 - 2.2e-08 34.3 5.9 0.13 12.3 0.1 5.2 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX52277.1 - 2.2e-07 31.2 0.2 1.4e-05 25.4 0.0 3.9 3 2 1 4 4 4 1 HEAT repeats Adaptin_N PF01602.20 ORX52277.1 - 1.9e-05 23.5 2.2 2.9e-05 22.8 0.3 2.3 3 1 0 3 3 3 1 Adaptin N terminal region HEAT PF02985.22 ORX52277.1 - 4e-05 23.5 3.9 0.16 12.3 0.0 5.1 6 0 0 6 6 6 2 HEAT repeat Dor1 PF04124.12 ORX52277.1 - 0.0051 15.5 1.2 0.0051 15.5 1.2 2.0 2 0 0 2 2 2 1 Dor1-like family RTP1_C1 PF10363.9 ORX52277.1 - 0.012 15.8 1.3 0.83 9.9 0.1 3.5 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ORX52277.1 - 0.012 16.1 1.3 8.2 7.0 0.0 3.9 3 0 0 3 3 3 0 HEAT-like repeat CLASP_N PF12348.8 ORX52277.1 - 0.054 13.1 0.1 0.51 9.9 0.0 2.7 2 1 1 3 3 3 0 CLASP N terminal Cohesin_HEAT PF12765.7 ORX52277.1 - 0.09 13.1 1.1 0.39 11.0 0.2 2.6 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion Arm PF00514.23 ORX52277.1 - 3.3 7.9 6.9 4 7.6 0.0 4.1 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Forkhead PF00250.18 ORX52278.1 - 8e-33 112.6 0.0 1.3e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 Forkhead domain 2OG-FeII_Oxy_3 PF13640.6 ORX52279.1 - 5.1e-10 40.1 0.0 8.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ORX52279.1 - 3.5e-06 27.4 0.0 1.3e-05 25.6 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 ORX52279.1 - 0.027 13.6 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus C4/C10 protein FA_desaturase PF00487.24 ORX52283.1 - 2.3e-23 83.3 13.9 3.8e-23 82.6 13.9 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 ORX52283.1 - 1.9e-09 36.8 0.6 3.4e-09 36.0 0.6 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Adipogenin PF15202.6 ORX52283.1 - 0.015 15.3 1.6 0.66 10.0 0.3 3.3 3 0 0 3 3 3 0 Adipogenin ArgJ PF01960.18 ORX52284.1 - 3.7e-150 499.9 2.5 4.2e-150 499.7 2.5 1.0 1 0 0 1 1 1 1 ArgJ family Pox_A12 PF04651.13 ORX52284.1 - 0.36 10.9 3.1 0.19 11.8 0.9 1.6 2 0 0 2 2 2 0 Poxvirus A12 protein Ribosomal_S7 PF00177.21 ORX52285.1 - 1.2e-37 128.8 0.8 1.5e-37 128.5 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e AA_permease_2 PF13520.6 ORX52289.1 - 6.8e-45 153.7 13.5 8.5e-45 153.3 13.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX52289.1 - 6.7e-16 57.9 14.5 8.7e-16 57.6 14.5 1.1 1 0 0 1 1 1 1 Amino acid permease Methyltransf_32 PF13679.6 ORX52290.1 - 2e-22 79.9 0.4 3e-22 79.3 0.4 1.3 1 0 0 1 1 1 1 Methyltransferase domain TRM13 PF05206.14 ORX52290.1 - 0.006 16.1 0.0 9.2 5.7 0.3 3.0 3 0 0 3 3 3 2 Methyltransferase TRM13 MTS PF05175.14 ORX52290.1 - 0.095 12.2 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX52290.1 - 0.1 13.3 0.1 0.22 12.2 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 ORX52290.1 - 0.16 12.1 0.2 0.26 11.4 0.2 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 ORX52290.1 - 0.19 11.5 0.1 0.45 10.3 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain Spc7 PF08317.11 ORX52291.1 - 1.6e-36 125.8 17.2 2.1e-36 125.4 17.2 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein AAA_19 PF13245.6 ORX52291.1 - 0.87 9.9 4.1 0.72 10.2 2.4 1.9 2 1 0 2 2 2 0 AAA domain Ribosomal_L6 PF00347.23 ORX52292.1 - 2.7e-27 95.2 0.2 8.5e-13 48.8 0.1 2.4 2 0 0 2 2 2 2 Ribosomal protein L6 SRF-TF PF00319.18 ORX52293.1 - 1.2e-21 76.0 0.1 1.2e-21 76.0 0.1 1.8 2 0 0 2 2 2 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Cytochrom_B558a PF05038.13 ORX52293.1 - 0.084 12.4 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Velvet PF11754.8 ORX52294.1 - 2.3e-38 132.6 1.7 2.3e-18 67.1 0.1 2.2 1 1 1 2 2 2 2 Velvet factor Methyltransf_11 PF08241.12 ORX52295.1 - 5.3e-22 78.3 0.0 2.3e-21 76.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX52295.1 - 1e-19 71.0 0.0 2.9e-19 69.6 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX52295.1 - 1.8e-15 57.0 0.0 2.8e-15 56.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX52295.1 - 2.8e-13 49.7 0.0 3.8e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX52295.1 - 4.1e-11 43.5 0.0 7.1e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX52295.1 - 0.00015 21.7 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX52295.1 - 0.001 18.9 0.0 0.0025 17.7 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase PCMT PF01135.19 ORX52295.1 - 0.007 16.1 0.0 0.01 15.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ORX52295.1 - 0.0071 15.9 0.0 0.021 14.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX52295.1 - 0.057 12.9 0.0 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase tRNA_U5-meth_tr PF05958.11 ORX52295.1 - 0.061 12.3 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 ORX52295.1 - 0.089 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Septin PF00735.18 ORX52297.1 - 2.4e-111 371.6 2.4 3.4e-111 371.0 2.4 1.3 1 0 0 1 1 1 1 Septin GTP_EFTU PF00009.27 ORX52297.1 - 3.2e-07 30.1 4.7 1.5e-06 27.9 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX52297.1 - 7.1e-07 29.3 0.0 2e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX52297.1 - 6.5e-06 26.1 3.7 1.4e-05 25.0 0.1 2.8 3 0 0 3 3 3 1 RsgA GTPase Roc PF08477.13 ORX52297.1 - 0.00033 20.9 0.1 0.00089 19.5 0.1 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.12 ORX52297.1 - 0.0014 18.2 0.1 0.0034 16.9 0.1 1.6 1 0 0 1 1 1 1 Poxvirus A32 protein AAA_22 PF13401.6 ORX52297.1 - 0.0022 18.3 1.7 0.0042 17.4 0.1 2.2 2 1 0 2 2 2 1 AAA domain Gtr1_RagA PF04670.12 ORX52297.1 - 0.0033 16.8 0.0 0.0091 15.4 0.0 1.7 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region IIGP PF05049.13 ORX52297.1 - 0.0085 15.2 0.0 0.017 14.2 0.0 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) Ras PF00071.22 ORX52297.1 - 0.012 15.2 0.3 0.032 13.8 0.3 1.7 1 1 0 1 1 1 0 Ras family AIG1 PF04548.16 ORX52297.1 - 0.015 14.7 0.0 0.015 14.7 0.0 1.8 2 0 0 2 2 1 0 AIG1 family AAA_24 PF13479.6 ORX52297.1 - 0.017 14.8 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX52297.1 - 0.032 14.4 0.5 0.82 9.8 0.0 3.0 2 1 1 3 3 3 0 AAA domain ABC_tran PF00005.27 ORX52297.1 - 0.034 14.7 0.5 0.11 13.0 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_7 PF12775.7 ORX52297.1 - 0.037 13.5 0.1 0.08 12.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region KAP_NTPase PF07693.14 ORX52297.1 - 0.047 12.9 0.0 0.11 11.7 0.0 1.9 1 1 0 1 1 1 0 KAP family P-loop domain RNA_helicase PF00910.22 ORX52297.1 - 0.055 13.9 0.0 0.17 12.3 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 ORX52297.1 - 0.056 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ORX52297.1 - 0.06 13.7 0.6 0.27 11.6 0.0 2.2 2 1 0 2 2 2 0 AAA ATPase domain FOXP-CC PF16159.5 ORX52297.1 - 0.082 13.5 2.7 0.22 12.2 1.9 2.2 1 1 0 1 1 1 0 FOXP coiled-coil domain AAA_25 PF13481.6 ORX52297.1 - 0.11 12.1 0.1 0.36 10.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX52297.1 - 0.12 11.7 2.0 0.16 11.3 0.1 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family Exonuc_VII_L PF02601.15 ORX52297.1 - 0.18 11.4 3.2 0.28 10.7 3.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ORX52297.1 - 0.39 10.0 4.4 0.7 9.2 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Dynamin_N PF00350.23 ORX52297.1 - 0.51 10.4 6.1 4.1 7.4 0.0 3.3 2 1 1 3 3 3 0 Dynamin family APG6_N PF17675.1 ORX52297.1 - 4.5 7.8 17.8 0.5 10.9 12.0 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region MMR_HSR1 PF01926.23 ORX52298.1 - 1.1e-18 67.4 0.3 1.6e-13 50.8 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX52298.1 - 4.2e-09 36.1 0.3 8.7e-06 25.3 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ORX52298.1 - 3.6e-07 29.9 0.1 3.4e-05 23.5 0.0 3.0 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX52298.1 - 7.5e-07 29.2 1.9 0.002 18.1 0.1 2.5 1 1 1 2 2 2 2 RsgA GTPase AIG1 PF04548.16 ORX52298.1 - 0.0023 17.3 0.4 0.53 9.6 0.1 2.3 2 0 0 2 2 2 2 AIG1 family Dynamin_N PF00350.23 ORX52298.1 - 0.0028 17.7 2.7 0.073 13.1 0.4 2.9 2 1 1 3 3 3 1 Dynamin family cobW PF02492.19 ORX52298.1 - 0.14 11.7 2.3 0.2 11.3 0.0 2.4 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 ORX52298.1 - 0.14 12.4 0.7 15 5.8 0.1 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_18 PF13238.6 ORX52298.1 - 0.14 12.7 0.0 0.45 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Tetraspanin PF00335.20 ORX52300.1 - 8e-11 42.1 13.2 1.5e-10 41.2 13.2 1.5 1 1 0 1 1 1 1 Tetraspanin family CoA_binding_3 PF13727.6 ORX52300.1 - 0.028 14.4 3.3 0.15 12.1 3.3 1.9 2 0 0 2 2 2 0 CoA-binding domain Wzy_C PF04932.15 ORX52300.1 - 0.21 11.2 4.1 0.65 9.6 4.1 2.0 1 1 0 1 1 1 0 O-Antigen ligase Ninjurin PF04923.12 ORX52300.1 - 1 9.4 5.6 11 6.0 1.2 2.9 2 1 0 3 3 3 0 Ninjurin DUF4131 PF13567.6 ORX52300.1 - 2 8.1 5.7 0.33 10.6 0.7 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) DUF2981 PF11200.8 ORX52300.1 - 3.1 7.5 8.0 1.2 8.9 5.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) DUF4383 PF14325.6 ORX52300.1 - 3.2 8.1 12.3 0.33 11.2 7.7 1.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4383) Cellulase PF00150.18 ORX52304.1 - 2.5e-08 33.7 1.8 0.0011 18.4 0.3 2.9 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) DUF4038 PF13204.6 ORX52304.1 - 0.0049 16.5 0.1 0.14 11.7 0.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4038) AP_endonuc_2 PF01261.24 ORX52304.1 - 0.029 13.8 0.0 0.13 11.7 0.0 2.1 3 0 0 3 3 3 0 Xylose isomerase-like TIM barrel DUF3220 PF11516.8 ORX52304.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3120) PhoD PF09423.10 ORX52305.1 - 2.2e-05 23.7 0.1 0.0012 17.9 0.1 2.2 1 1 0 1 1 1 1 PhoD-like phosphatase PP-binding PF00550.25 ORX52306.1 - 2e-13 50.5 0.4 2.5e-13 50.2 0.4 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ORX52306.1 - 0.00037 20.7 1.7 0.00062 19.9 1.7 1.5 1 1 0 1 1 1 1 Acyl-carrier Arf PF00025.21 ORX52307.1 - 1.2e-46 158.4 0.3 1.4e-46 158.1 0.3 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ORX52307.1 - 2.3e-21 76.1 0.0 2.9e-21 75.8 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX52307.1 - 5.2e-18 65.4 0.0 8e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX52307.1 - 3.3e-11 43.0 0.0 4e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ORX52307.1 - 3.2e-10 39.7 0.4 2.8e-07 30.0 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX52307.1 - 1.1e-09 38.0 0.1 1.3e-09 37.8 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX52307.1 - 1.3e-08 34.9 0.0 2e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX52307.1 - 0.00044 19.9 0.1 0.012 15.1 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX52307.1 - 0.0019 18.5 0.1 0.059 13.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 ORX52307.1 - 0.013 15.6 0.1 0.55 10.3 0.3 2.2 1 1 1 2 2 2 0 Dynamin family AAA_7 PF12775.7 ORX52307.1 - 0.031 13.8 0.0 0.055 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 ORX52307.1 - 0.079 12.5 1.8 0.14 11.7 0.1 2.0 2 1 0 2 2 2 0 Ferrous iron transport protein B TniB PF05621.11 ORX52307.1 - 0.12 11.8 0.1 2.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein UBX PF00789.20 ORX52309.1 - 1.3e-16 60.5 0.0 2.7e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 UBX domain UBA PF00627.31 ORX52309.1 - 0.0033 17.3 0.0 0.0078 16.1 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain zf-C2H2_2 PF12756.7 ORX52309.1 - 0.083 13.2 0.3 0.18 12.2 0.3 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 ORX52309.1 - 0.2 12.2 0.1 0.4 11.2 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type CDC27 PF09507.10 ORX52309.1 - 8.3 5.7 24.2 11 5.3 24.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Cyanate_lyase PF02560.14 ORX52310.1 - 8.6e-36 121.6 0.0 1.2e-35 121.1 0.0 1.3 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_3 PF01381.22 ORX52310.1 - 1.3e-06 28.4 0.0 5.4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix HTH_26 PF13443.6 ORX52310.1 - 0.0012 19.2 0.0 0.002 18.6 0.0 1.3 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_19 PF12844.7 ORX52310.1 - 0.0013 18.7 0.0 0.0031 17.5 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_31 PF13560.6 ORX52310.1 - 0.0045 17.3 0.0 0.0063 16.8 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HP0268 PF18618.1 ORX52310.1 - 0.089 13.2 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 HP0268 FAA_hydrolase PF01557.18 ORX52311.1 - 4.3e-58 196.5 0.0 5e-58 196.3 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family HMG_box PF00505.19 ORX52313.1 - 2.2e-39 133.7 5.7 8.5e-20 70.9 0.3 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX52313.1 - 6.4e-28 97.2 1.5 1.2e-12 48.2 0.2 2.4 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.6 ORX52313.1 - 0.0002 21.2 0.7 0.0002 21.2 0.7 1.8 2 0 0 2 2 2 1 HMG (high mobility group) box 5 CHDNT PF08073.12 ORX52313.1 - 0.00022 21.1 0.0 0.075 13.0 0.0 2.5 2 0 0 2 2 2 2 CHDNT (NUC034) domain Protamine_like PF06382.11 ORX52313.1 - 0.14 12.4 2.5 0.3 11.3 0.1 2.3 2 0 0 2 2 2 0 Protamine and protamine like DUF2461 PF09365.10 ORX52314.1 - 2e-55 188.0 0.0 3.2e-55 187.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) PQQ_2 PF13360.6 ORX52315.1 - 7.4e-14 51.9 0.0 2.8e-06 27.1 0.0 2.6 1 1 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 ORX52315.1 - 2.3e-11 43.0 1.4 0.15 12.1 0.0 4.3 4 0 0 4 4 4 4 PQQ enzyme repeat PQQ_3 PF13570.6 ORX52315.1 - 1.5e-07 31.7 0.8 0.19 12.3 0.1 4.9 6 1 0 6 6 6 2 PQQ-like domain ERCC3_RAD25_C PF16203.5 ORX52316.1 - 8.6e-64 215.1 9.4 6.9e-39 133.5 0.1 3.4 2 1 1 3 3 3 2 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ORX52316.1 - 4e-19 69.2 0.0 1.3e-18 67.6 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX52316.1 - 7e-09 36.0 0.2 3.6e-08 33.7 0.2 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ORX52316.1 - 1.4e-06 27.3 0.2 3.7e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.29 ORX52316.1 - 0.00017 21.4 0.1 0.00067 19.5 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_34 PF13872.6 ORX52316.1 - 0.0003 19.8 0.0 0.00054 18.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 SWI2_SNF2 PF18766.1 ORX52316.1 - 0.0035 17.0 0.0 0.014 15.1 0.0 1.9 1 1 0 1 1 1 1 SWI2/SNF2 ATPase G_glu_transpept PF01019.21 ORX52317.1 - 3.2e-176 587.1 0.0 3.7e-176 586.9 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase HA2 PF04408.23 ORX52318.1 - 3.8e-14 52.9 0.0 1.2e-13 51.2 0.0 1.9 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ORX52318.1 - 1.4e-07 31.8 0.1 1.1e-06 28.9 0.0 2.3 2 1 1 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX52318.1 - 0.043 13.6 0.5 0.13 12.0 0.2 1.9 1 1 1 2 2 2 0 DEAD/DEAH box helicase Ribosomal_L11_N PF03946.14 ORX52319.1 - 2e-23 82.0 0.1 3.2e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ORX52319.1 - 1.9e-18 66.7 0.1 3.4e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain MATalpha_HMGbox PF04769.12 ORX52320.1 - 0.1 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box zf-C2H2_4 PF13894.6 ORX52322.1 - 0.0043 17.8 0.1 0.0071 17.1 0.1 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-RVT PF13966.6 ORX52323.1 - 3.8e-06 27.5 0.0 6.5e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-C2H2_4 PF13894.6 ORX52324.1 - 1e-06 29.1 2.7 0.036 14.9 0.1 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX52324.1 - 1.2e-06 28.7 7.1 0.00028 21.2 0.5 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX52324.1 - 1.1e-05 25.6 9.1 0.00014 22.1 0.1 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-TRAF PF02176.18 ORX52324.1 - 0.0068 17.1 6.0 0.011 16.4 1.9 2.1 1 1 1 2 2 2 1 TRAF-type zinc finger zf-H2C2_5 PF13909.6 ORX52324.1 - 0.034 13.9 0.3 0.034 13.9 0.3 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 ORX52324.1 - 0.078 13.3 6.9 3.2 8.1 0.6 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding HEAT_2 PF13646.6 ORX52325.1 - 2.8e-10 40.4 3.3 0.0029 17.9 0.1 6.0 4 1 1 5 5 5 3 HEAT repeats Adaptin_N PF01602.20 ORX52325.1 - 1e-05 24.4 0.7 0.037 12.6 0.0 3.6 3 0 0 3 3 3 2 Adaptin N terminal region Arm PF00514.23 ORX52325.1 - 9.1e-05 22.4 0.5 0.054 13.6 0.4 4.8 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ORX52325.1 - 0.0012 18.9 25.4 3.3 8.2 0.0 8.7 10 0 0 10 10 10 4 HEAT repeat HEAT_EZ PF13513.6 ORX52325.1 - 0.23 12.0 0.1 0.23 12.0 0.1 7.2 7 2 2 10 10 10 0 HEAT-like repeat Cytomega_UL20A PF05984.12 ORX52325.1 - 1.7 9.0 7.8 0.34 11.3 2.3 2.4 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein DUF2499 PF10693.9 ORX52326.1 - 0.038 14.2 0.0 0.067 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2499) Ribosomal_L11_N PF03946.14 ORX52327.1 - 2e-23 82.0 0.1 3.2e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 ORX52327.1 - 1.9e-18 66.7 0.1 3.4e-18 65.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain zf-C2H2 PF00096.26 ORX52328.1 - 4.1e-16 58.4 29.6 2.1e-06 27.9 1.7 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX52328.1 - 2.3e-11 43.5 27.7 0.0011 19.6 1.4 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX52328.1 - 2.2e-05 24.7 12.2 0.00011 22.5 5.2 5.0 4 2 1 5 5 5 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX52328.1 - 0.00025 21.2 10.1 0.95 9.8 0.4 3.8 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 ORX52328.1 - 0.0011 19.6 0.3 0.0011 19.6 0.3 3.3 2 1 1 3 3 3 1 TRAF-type zinc finger zf_ZIC PF18366.1 ORX52328.1 - 0.0072 16.4 13.3 0.018 15.2 0.3 4.2 3 1 1 4 4 4 1 Zic proteins zinc finger domain zf-C2H2_2 PF12756.7 ORX52328.1 - 0.021 15.1 15.7 0.17 12.2 10.5 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 ORX52328.1 - 0.034 13.9 2.3 0.034 13.9 2.3 4.3 5 0 0 5 5 5 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 ORX52328.1 - 0.049 13.7 0.2 0.049 13.7 0.2 4.5 4 1 0 4 4 4 0 C2H2-type zinc finger zf-met PF12874.7 ORX52328.1 - 0.11 13.0 10.7 11 6.6 0.3 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-FPG_IleRS PF06827.14 ORX52328.1 - 0.42 10.5 9.8 1.5 8.8 0.5 3.3 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS ADK_lid PF05191.14 ORX52328.1 - 0.56 10.2 11.7 5.4 7.1 5.9 3.2 2 1 0 2 2 2 0 Adenylate kinase, active site lid zinc_ribbon_15 PF17032.5 ORX52328.1 - 0.76 10.6 12.0 0.53 11.1 5.2 2.5 2 1 0 2 2 2 0 zinc-ribbon family zf-C2HC_2 PF13913.6 ORX52328.1 - 2.5 8.1 19.8 9.7 6.2 0.1 4.7 4 1 0 4 4 4 0 zinc-finger of a C2HC-type DUF629 PF04780.12 ORX52328.1 - 9.6 4.6 14.8 2.2 6.7 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF629) RRM_1 PF00076.22 ORX52329.1 - 1.6e-06 27.8 0.0 2.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1590 PF07629.11 ORX52329.1 - 0.053 13.3 0.8 0.053 13.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1590) Secretin_N_2 PF07655.13 ORX52329.1 - 0.61 10.7 10.6 0.13 12.8 6.9 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain Acetyltransf_3 PF13302.7 ORX52330.1 - 4.3e-25 89.0 0.1 1.2e-24 87.6 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX52330.1 - 3e-08 33.9 0.0 4.9e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ORX52330.1 - 7.4e-07 29.0 0.0 1.2e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ORX52330.1 - 6.6e-06 25.9 0.0 9.7e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX52330.1 - 0.00081 19.6 0.0 0.0018 18.4 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain PRANC PF09372.10 ORX52331.1 - 0.00062 20.1 0.2 0.0013 19.0 0.2 1.6 1 0 0 1 1 1 1 PRANC domain F-box-like PF12937.7 ORX52331.1 - 0.0077 16.1 0.1 0.018 14.9 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX52331.1 - 0.017 15.0 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 F-box domain FAR1 PF03101.15 ORX52333.1 - 0.00085 20.0 0.7 0.0022 18.6 0.7 1.8 1 0 0 1 1 1 1 FAR1 DNA-binding domain TFIIA PF03153.13 ORX52333.1 - 3.5 7.5 11.9 5.9 6.8 11.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Xpo1 PF08389.12 ORX52334.1 - 7.1e-35 120.3 0.1 3.1e-33 114.9 0.0 3.0 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 ORX52334.1 - 2.4e-08 33.8 0.1 1.4e-07 31.3 0.1 2.4 1 1 0 1 1 1 1 Importin-beta N-terminal domain GRIP PF01465.20 ORX52334.1 - 0.042 13.8 0.0 0.16 11.9 0.0 2.0 1 0 0 1 1 1 0 GRIP domain Sec1 PF00995.23 ORX52335.1 - 3.9e-103 346.6 0.0 4.5e-103 346.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Sybindin PF04099.12 ORX52335.1 - 0.075 13.0 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Sybindin-like family ComC PF03047.14 ORX52335.1 - 6.1 6.8 5.0 1.4 8.8 0.8 2.2 2 0 0 2 2 2 0 COMC family Sec1 PF00995.23 ORX52338.1 - 1.5e-15 57.5 0.0 1.7e-15 57.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Transket_pyr PF02779.24 ORX52341.1 - 2.4e-45 154.4 0.0 3.8e-45 153.7 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX52341.1 - 2.8e-41 140.3 0.1 5.8e-41 139.3 0.1 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 ORX52341.1 - 0.017 15.4 0.0 0.038 14.3 0.0 1.6 1 0 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II Pkinase PF00069.25 ORX52342.1 - 1.6e-71 240.7 0.0 3.4e-71 239.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52342.1 - 3.5e-29 101.9 0.0 2.8e-28 98.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ORX52342.1 - 9.1e-05 22.1 0.4 0.00013 21.6 0.4 1.3 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ORX52342.1 - 0.0012 18.2 0.3 0.54 9.5 0.0 2.6 2 1 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ORX52342.1 - 0.028 13.2 0.0 0.053 12.3 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ORX52342.1 - 0.056 12.8 0.2 0.15 11.4 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ORX52343.1 - 1.1e-69 234.7 0.0 1.3e-69 234.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52343.1 - 1.5e-36 126.1 0.0 1.8e-36 125.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX52343.1 - 1.4e-05 24.6 0.0 2.9e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ORX52343.1 - 0.0023 17.1 0.0 0.0037 16.4 0.0 1.3 1 0 0 1 1 1 1 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 ORX52343.1 - 0.043 13.3 0.0 0.083 12.4 0.0 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL APH PF01636.23 ORX52343.1 - 0.087 12.7 0.0 0.27 11.1 0.0 1.7 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX52343.1 - 0.15 11.0 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Ribosomal_L5_C PF00673.21 ORX52345.1 - 7.6e-22 77.3 0.0 1.1e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ORX52345.1 - 2.4e-18 66.2 0.1 8.2e-18 64.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 ORX52345.1 - 0.18 11.6 0.1 0.35 10.6 0.1 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Acyl-CoA_dh_1 PF00441.24 ORX52346.1 - 2.3e-48 164.2 1.6 4.6e-48 163.2 1.6 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX52346.1 - 1.1e-28 100.2 1.5 1.2e-28 100.0 0.2 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX52346.1 - 6.8e-22 78.2 0.3 1.5e-21 77.1 0.3 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX52346.1 - 1.4e-21 76.5 0.0 2.7e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain NIF3 PF01784.18 ORX52347.1 - 3.8e-67 226.5 0.0 4.6e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ECD PF18432.1 ORX52347.1 - 0.16 12.0 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Extracellular Cadherin domain CHD5 PF04420.14 ORX52348.1 - 5.7e-56 188.8 0.3 6.9e-56 188.5 0.3 1.1 1 0 0 1 1 1 1 CHD5-like protein T3SS_needle_E PF08988.10 ORX52348.1 - 0.048 13.8 0.1 0.078 13.1 0.1 1.3 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle PI_PP_C PF18365.1 ORX52349.1 - 0.022 14.7 0.2 0.035 14.1 0.2 1.3 1 0 0 1 1 1 0 Phosphoinositide phosphatase C-terminal domain Rz1 PF06085.11 ORX52349.1 - 0.099 12.4 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Lipoprotein Rz1 precursor OSR1_C PF12202.8 ORX52351.1 - 0.055 13.7 0.2 0.15 12.3 0.1 1.9 2 0 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain BID PF06393.11 ORX52353.1 - 0.078 12.5 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 BH3 interacting domain (BID) zf_C2H2_10 PF18414.1 ORX52354.1 - 0.0052 16.3 4.4 0.045 13.3 4.4 2.4 1 1 0 1 1 1 1 C2H2 type zinc-finger CRISPR_Cse1 PF09481.10 ORX52354.1 - 0.067 12.3 0.3 0.1 11.6 0.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein Cse1 (CRISPR_cse1) zf-C2H2_4 PF13894.6 ORX52354.1 - 0.082 13.8 0.1 0.46 11.5 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Abhydrolase_9 PF10081.9 ORX52354.1 - 0.088 11.9 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family EMC3_TMCO1 PF01956.16 ORX52355.1 - 7.5e-51 172.2 1.1 7.5e-51 172.2 1.1 1.6 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like SOBP PF15279.6 ORX52355.1 - 0.016 15.8 1.5 0.064 13.9 0.1 2.0 2 0 0 2 2 2 0 Sine oculis-binding protein DUF975 PF06161.11 ORX52355.1 - 0.14 12.0 1.1 0.76 9.5 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF975) Asp PF00026.23 ORX52356.1 - 9.1e-86 288.1 0.1 1e-85 287.9 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX52356.1 - 3.7e-12 46.9 1.3 8.8e-07 29.3 0.1 3.1 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 ORX52356.1 - 0.0014 19.2 0.0 2 9.0 0.0 2.6 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ORX52356.1 - 0.0016 19.0 0.0 3.7 8.3 0.0 3.0 2 1 0 2 2 2 2 Aspartyl protease TAXi_C PF14541.6 ORX52356.1 - 0.0095 15.7 0.0 0.41 10.4 0.0 2.3 1 1 1 2 2 2 1 Xylanase inhibitor C-terminal Ldh_1_N PF00056.23 ORX52357.1 - 3e-17 63.0 0.0 4.2e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ORX52357.1 - 0.003 18.1 0.0 0.0066 17.0 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent ApbA PF02558.16 ORX52357.1 - 0.0057 16.3 0.0 0.0095 15.6 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 ORX52357.1 - 0.069 13.4 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 ORX52357.1 - 0.075 12.6 0.9 0.76 9.3 0.9 2.1 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ORX52357.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.21 ORX52357.1 - 0.92 8.8 4.1 1.6 8.1 1.7 2.0 1 1 1 2 2 2 0 ThiF family ArfGap PF01412.18 ORX52358.1 - 1.6e-33 115.3 0.0 1.8e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-dskA_traR PF01258.17 ORX52358.1 - 0.079 12.9 0.7 11 6.1 0.1 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger UBA PF00627.31 ORX52359.1 - 0.048 13.6 0.5 4 7.4 0.1 2.7 2 0 0 2 2 2 0 UBA/TS-N domain HOIP-UBA PF16678.5 ORX52359.1 - 0.29 11.1 12.5 0.85 9.6 0.1 3.0 2 1 1 3 3 3 0 HOIP UBA domain pair FAM199X PF15814.5 ORX52359.1 - 1.2 8.1 3.4 1.9 7.5 3.4 1.2 1 0 0 1 1 1 0 Protein family FAM199X Muted PF14942.6 ORX52359.1 - 4.9 7.5 14.2 1.4 9.2 6.4 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein PLDc PF00614.22 ORX52360.1 - 1.3e-15 56.9 3.3 3.9e-07 30.0 0.4 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX52360.1 - 1.5e-11 44.3 0.8 2.8e-10 40.2 0.2 2.8 2 2 0 2 2 2 1 PLD-like domain PX PF00787.24 ORX52360.1 - 4.9e-08 32.9 0.0 1.1e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 PX domain PH PF00169.29 ORX52360.1 - 0.038 14.5 0.4 0.099 13.2 0.4 1.8 1 0 0 1 1 1 0 PH domain SieB PF14163.6 ORX52363.1 - 0.012 15.1 0.1 0.033 13.7 0.1 1.6 2 0 0 2 2 2 0 Super-infection exclusion protein B Shisa PF13908.6 ORX52363.1 - 0.024 14.9 0.1 0.039 14.2 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator COX6C PF02937.15 ORX52363.1 - 0.032 14.4 0.1 0.061 13.5 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc DUF3188 PF11384.8 ORX52363.1 - 0.047 13.4 0.3 0.079 12.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Orf78 PF06024.12 ORX52363.1 - 0.077 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) OPA3 PF07047.12 ORX52363.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) TP6A_N PF04406.14 ORX52364.1 - 2.2e-22 78.8 1.7 5e-22 77.7 1.7 1.6 1 0 0 1 1 1 1 Type IIB DNA topoisomerase Shisa PF13908.6 ORX52365.1 - 0.026 14.8 0.1 0.046 14.0 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator COX6C PF02937.15 ORX52365.1 - 0.059 13.5 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc F-box-like PF12937.7 ORX52367.1 - 1.4e-11 44.1 0.4 4.2e-11 42.6 0.4 1.9 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.28 ORX52367.1 - 5e-05 22.9 1.9 0.22 11.4 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat LRR_6 PF13516.6 ORX52367.1 - 7.9e-05 22.4 1.0 0.054 13.6 0.0 4.4 4 0 0 4 4 4 1 Leucine Rich repeat TPR_2 PF07719.17 ORX52367.1 - 0.00019 21.3 2.2 0.2 11.8 0.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat F-box PF00646.33 ORX52367.1 - 0.00025 20.8 0.0 0.0014 18.5 0.0 2.3 1 0 0 1 1 1 1 F-box domain TPR_16 PF13432.6 ORX52367.1 - 0.0013 19.3 0.3 0.54 10.9 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX52367.1 - 0.0021 18.2 1.8 0.0058 16.8 1.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ORX52367.1 - 0.0069 16.7 5.4 2.1 8.7 0.2 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX52367.1 - 0.055 14.0 0.5 0.37 11.3 0.2 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX52367.1 - 0.13 12.3 0.4 0.31 11.1 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2471 PF10616.9 ORX52368.1 - 0.073 13.6 3.0 0.63 10.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2471) SbcD_C PF12320.8 ORX52368.1 - 0.094 13.0 5.0 8.5 6.7 1.5 3.0 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Rotamase_3 PF13616.6 ORX52369.1 - 7.6e-18 65.1 0.4 3.4e-17 63.1 0.4 2.0 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 ORX52369.1 - 1.7e-15 57.8 0.0 2.8e-15 57.1 0.0 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ORX52369.1 - 0.15 12.9 0.0 0.23 12.3 0.0 1.4 1 1 0 1 1 1 0 PPIC-type PPIASE domain HSF_DNA-bind PF00447.17 ORX52370.1 - 7.9e-29 100.1 1.8 7.9e-29 100.1 1.8 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding DUF3456 PF11938.8 ORX52370.1 - 0.072 13.6 0.6 0.098 13.2 0.6 1.2 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP Ribo_biogen_C PF04034.13 ORX52372.1 - 2.4e-53 179.2 0.0 3.4e-53 178.7 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ORX52372.1 - 2.4e-09 36.8 2.5 4.3e-09 36.0 2.5 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI CDC45 PF02724.14 ORX52372.1 - 0.003 16.0 13.4 0.0039 15.5 13.4 1.2 1 0 0 1 1 1 1 CDC45-like protein Saw1 PF11561.8 ORX52372.1 - 0.18 11.3 1.3 0.28 10.7 1.3 1.3 1 0 0 1 1 1 0 Single strand annealing-weakened 1 SDA1 PF05285.12 ORX52372.1 - 0.3 10.5 25.0 0.4 10.1 25.0 1.1 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ORX52372.1 - 0.36 10.1 27.2 0.61 9.3 27.2 1.3 1 0 0 1 1 1 0 NOA36 protein Roughex PF06020.11 ORX52372.1 - 0.46 9.5 8.8 0.68 9.0 8.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein FAM60A PF15396.6 ORX52372.1 - 0.96 9.4 4.7 1.3 9.0 4.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SURF2 PF05477.11 ORX52372.1 - 1 9.0 14.6 1.4 8.5 14.6 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) BUD22 PF09073.10 ORX52372.1 - 1.3 8.2 26.9 1.8 7.8 26.9 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ORX52372.1 - 2.6 6.1 29.7 3.4 5.8 29.7 1.0 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 ORX52372.1 - 3.5 6.9 25.0 5.7 6.3 25.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pes-10 PF07149.11 ORX52372.1 - 4.3 6.3 18.4 5.3 6.0 18.4 1.1 1 0 0 1 1 1 0 Pes-10 DUF913 PF06025.12 ORX52372.1 - 5.7 5.8 7.8 7.8 5.4 7.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ORX52372.1 - 6 5.5 8.0 7.9 5.1 8.0 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 ORX52372.1 - 7.5 6.4 19.7 12 5.7 19.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spc7_N PF15402.6 ORX52372.1 - 9.2 4.4 17.5 12 4.0 17.5 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Ribosomal_L18 PF17135.4 ORX52373.1 - 9.4e-91 302.3 5.6 1e-90 302.1 5.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ORX52373.1 - 0.0015 19.2 0.3 0.0056 17.3 0.3 2.0 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A TUG-UBL1 PF11470.8 ORX52378.1 - 0.038 14.2 0.2 0.46 10.7 0.1 2.0 1 1 1 2 2 2 0 TUG ubiquitin-like domain SH3_1 PF00018.28 ORX52380.1 - 1.8e-29 101.0 0.0 4.8e-15 54.9 0.0 2.5 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ORX52380.1 - 4.4e-18 64.9 0.0 8.8e-10 38.3 0.0 2.8 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 ORX52380.1 - 6.6e-12 45.4 0.1 1.6e-11 44.1 0.1 1.6 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 ORX52380.1 - 1.9e-11 43.4 0.0 8.5e-08 31.8 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 ORX52380.1 - 3.5e-06 26.9 0.0 8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 PB1 domain CCDC53 PF10152.9 ORX52380.1 - 5.4 7.4 14.1 16 5.8 0.4 3.2 3 0 0 3 3 3 0 Subunit CCDC53 of WASH complex Vps51 PF08700.11 ORX52382.1 - 4.7e-23 81.1 2.0 4.7e-23 81.1 2.0 2.0 2 0 0 2 2 1 1 Vps51/Vps67 Sec5 PF15469.6 ORX52382.1 - 9.4e-22 77.7 2.2 2.5e-21 76.4 2.2 1.7 1 0 0 1 1 1 1 Exocyst complex component Sec5 Dor1 PF04124.12 ORX52382.1 - 2e-14 53.0 5.2 4.7e-14 51.8 5.2 1.5 1 0 0 1 1 1 1 Dor1-like family Vps54_N PF10475.9 ORX52382.1 - 1.9e-07 30.7 3.8 1.9e-07 30.7 3.8 2.0 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 ORX52382.1 - 5.8e-06 25.2 2.6 5.8e-06 25.2 2.6 1.8 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 COG2 PF06148.11 ORX52382.1 - 1.3e-05 25.3 1.5 4.4e-05 23.6 1.5 1.9 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 ORX52382.1 - 0.00053 20.2 0.7 0.00053 20.2 0.7 2.6 2 0 0 2 2 2 1 Golgi transport complex subunit 5 MitMem_reg PF13012.6 ORX52382.1 - 0.0012 19.2 3.7 0.01 16.2 0.4 3.5 3 0 0 3 3 3 1 Maintenance of mitochondrial structure and function Vps53_N PF04100.12 ORX52382.1 - 0.002 17.2 3.9 0.002 17.2 3.9 2.2 2 1 0 2 2 2 1 Vps53-like, N-terminal CENP-F_leu_zip PF10473.9 ORX52382.1 - 0.0033 17.5 2.9 0.0069 16.4 2.9 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dad4 PF08650.10 ORX52382.1 - 0.026 14.5 0.2 0.11 12.4 0.2 2.1 1 0 0 1 1 1 0 DASH complex subunit Dad4 PUB PF09409.10 ORX52382.1 - 0.053 13.5 0.1 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 PUB domain CK2S PF15011.6 ORX52382.1 - 0.24 11.3 4.7 2.5 8.0 0.3 3.0 2 1 0 2 2 2 0 Casein Kinase 2 substrate DUF16 PF01519.16 ORX52382.1 - 0.35 11.4 4.0 0.98 9.9 2.5 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 Occludin_ELL PF07303.13 ORX52382.1 - 0.41 11.4 3.5 10 6.9 1.2 3.0 1 1 1 2 2 2 0 Occludin homology domain YabA PF06156.13 ORX52382.1 - 0.42 11.3 4.0 1.1 10.0 2.5 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Laminin_II PF06009.12 ORX52382.1 - 0.46 10.5 3.1 1.5 8.8 3.1 1.9 1 0 0 1 1 1 0 Laminin Domain II ZapB PF06005.12 ORX52382.1 - 0.65 10.5 5.9 0.18 12.3 1.7 2.2 2 0 0 2 2 2 0 Cell division protein ZapB BLOC1_2 PF10046.9 ORX52382.1 - 0.65 10.3 5.0 1.6 9.1 1.6 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4795 PF16043.5 ORX52382.1 - 1 8.9 5.3 0.22 11.1 1.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Enkurin PF13864.6 ORX52382.1 - 1.2 9.6 3.7 2.6 8.5 0.3 3.1 3 0 0 3 3 2 0 Calmodulin-binding Jnk-SapK_ap_N PF09744.9 ORX52382.1 - 1.2 9.3 6.5 0.53 10.5 2.2 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 AI-2E_transport PF01594.16 ORX52382.1 - 2 7.5 5.7 0.37 9.9 0.2 2.4 3 0 0 3 3 3 0 AI-2E family transporter DUF1664 PF07889.12 ORX52382.1 - 2.3 8.3 5.5 2.3 8.3 1.9 2.9 4 0 0 4 4 3 0 Protein of unknown function (DUF1664) FlgN PF05130.12 ORX52382.1 - 4.3 7.8 6.8 2.5 8.6 3.0 2.3 2 0 0 2 2 2 0 FlgN protein Sec8_exocyst PF04048.14 ORX52382.1 - 6.9 6.6 9.1 1.9 8.4 3.3 2.4 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain NAD_binding_4 PF07993.12 ORX52383.1 - 2.3e-40 138.4 0.0 3.8e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Acyltransferase PF01553.21 ORX52383.1 - 3.9e-07 29.7 0.0 8e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Epimerase PF01370.21 ORX52383.1 - 6.1e-05 22.6 0.1 0.00037 20.0 0.1 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX52383.1 - 0.0054 16.2 0.2 1 8.7 0.0 2.3 1 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ORX52383.1 - 0.016 14.4 0.0 0.44 9.6 0.0 2.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ORX52383.1 - 0.075 12.0 0.3 4.1 6.3 0.3 2.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family SUIM_assoc PF16619.5 ORX52383.1 - 3.2 7.9 11.5 0.11 12.6 1.1 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 IATP PF04568.12 ORX52384.1 - 3.6e-08 33.7 3.7 3.9e-08 33.6 3.7 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP S4 PF01479.25 ORX52385.1 - 3.4e-13 49.1 0.0 1.7e-12 46.9 0.0 2.2 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 ORX52385.1 - 3.9e-12 46.9 1.4 6.5e-12 46.2 1.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain RRM_1 PF00076.22 ORX52386.1 - 2.9e-31 107.1 0.0 2.7e-16 59.1 0.1 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX52386.1 - 2.9e-06 27.3 0.4 0.096 12.8 0.0 2.2 2 0 0 2 2 2 2 Limkain b1 RRM_3 PF08777.11 ORX52386.1 - 2.2e-05 24.4 0.0 0.022 14.8 0.0 2.2 2 0 0 2 2 2 2 RNA binding motif RRM_5 PF13893.6 ORX52386.1 - 0.0007 19.2 0.0 0.36 10.4 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 ORX52386.1 - 0.022 14.4 0.0 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 ORX52386.1 - 0.13 12.4 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ORX52386.1 - 0.14 12.2 0.0 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ORX52386.1 - 0.15 12.0 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif RNA_bind PF08675.11 ORX52386.1 - 0.17 12.0 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain SWIM PF04434.17 ORX52387.1 - 2e-05 24.1 0.4 4.2e-05 23.1 0.4 1.6 1 0 0 1 1 1 1 SWIM zinc finger zf-RING_2 PF13639.6 ORX52387.1 - 4.6e-05 23.7 8.6 4.6e-05 23.7 8.6 2.1 2 0 0 2 2 2 1 Ring finger domain C1_1 PF00130.22 ORX52387.1 - 0.00069 19.4 2.1 0.00069 19.4 2.1 2.1 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 ORX52387.1 - 0.004 17.1 5.2 0.004 17.1 5.2 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 zf-ANAPC11 PF12861.7 ORX52387.1 - 0.0087 16.1 1.7 0.024 14.7 1.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 ORX52387.1 - 0.011 15.9 4.4 0.027 14.6 4.4 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_2 PF13831.6 ORX52387.1 - 0.016 14.7 2.6 0.038 13.5 2.6 1.7 1 0 0 1 1 1 0 PHD-finger PHD PF00628.29 ORX52387.1 - 0.032 14.1 7.1 0.089 12.7 7.3 1.7 1 1 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.6 ORX52387.1 - 0.051 13.6 0.8 0.051 13.6 0.8 2.1 2 1 0 2 2 2 0 RING-type zinc-finger FYVE PF01363.21 ORX52387.1 - 1.5 9.1 13.4 0.038 14.1 3.8 2.4 2 0 0 2 2 2 0 FYVE zinc finger Zn_ribbon_17 PF17120.5 ORX52387.1 - 2.3 7.9 13.1 0.063 12.9 5.7 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 ORX52387.1 - 5.6 7.2 12.7 0.41 10.8 7.6 1.8 2 0 0 2 2 2 0 RING-variant domain Rhomboid PF01694.22 ORX52388.1 - 4.5e-27 94.9 12.1 7.5e-27 94.2 12.1 1.3 1 0 0 1 1 1 1 Rhomboid family Trep_Strep PF09605.10 ORX52388.1 - 0.012 15.7 0.2 0.029 14.4 0.2 1.6 1 0 0 1 1 1 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF1751 PF08551.10 ORX52388.1 - 0.11 13.1 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) Ribonuc_red_lgC PF02867.15 ORX52389.1 - 4.7e-186 619.4 0.0 6e-186 619.0 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ORX52389.1 - 3.6e-25 87.8 0.0 9e-25 86.5 0.0 1.7 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ORX52389.1 - 2.1e-16 60.2 0.0 6.4e-16 58.7 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain Ly-6_related PF06579.12 ORX52389.1 - 0.041 14.1 0.4 0.15 12.4 0.3 2.0 2 0 0 2 2 2 0 Caenorhabditis elegans ly-6-related protein PTS_2-RNA PF01885.16 ORX52390.1 - 2.7e-66 223.0 0.1 3.2e-66 222.8 0.1 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Cyclin PF08613.11 ORX52391.1 - 5e-12 46.5 0.6 2.6e-11 44.1 0.0 2.1 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 ORX52391.1 - 0.0001 22.0 0.2 0.00025 20.8 0.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Spt20 PF12090.8 ORX52391.1 - 0.0053 16.4 14.4 0.0053 16.4 14.4 1.6 2 0 0 2 2 2 1 Spt20 family CCDC117 PF15810.5 ORX52391.1 - 0.15 12.4 5.5 0.46 10.8 5.5 1.8 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 Cnd2 PF05786.14 ORX52391.1 - 5.1 5.6 7.0 7.2 5.1 7.0 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 PIG-Y PF15159.6 ORX52392.1 - 8.5e-20 71.5 11.8 1.1e-19 71.1 11.8 1.2 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIG-P PF08510.12 ORX52392.1 - 8.4 6.3 10.7 11 5.9 10.7 1.2 1 0 0 1 1 1 0 PIG-P Mt_ATP-synt_B PF05405.14 ORX52393.1 - 1e-49 168.3 8.1 1.3e-49 167.9 8.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF5623 PF18536.1 ORX52393.1 - 0.12 12.6 1.2 0.31 11.3 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5623) Fib_alpha PF08702.10 ORX52393.1 - 8.6 6.5 10.8 39 4.4 10.2 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Pkinase PF00069.25 ORX52394.1 - 7e-28 97.7 0.3 1.3e-27 96.8 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52394.1 - 2.7e-14 53.1 0.5 4.3e-14 52.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX52394.1 - 5.2e-10 38.7 0.6 2.3e-09 36.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX52394.1 - 0.00036 20.5 3.1 0.0049 16.8 0.0 2.7 2 1 0 3 3 3 1 Phosphotransferase enzyme family Syntaxin PF00804.25 ORX52394.1 - 0.17 11.6 4.9 0.29 10.8 4.9 1.3 1 0 0 1 1 1 0 Syntaxin TFIIA PF03153.13 ORX52394.1 - 0.73 9.8 14.3 1 9.3 14.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RPM2 PF08579.11 ORX52395.1 - 0.1 13.0 0.1 0.18 12.2 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) CCDC24 PF15669.5 ORX52397.1 - 0.0038 17.1 2.5 0.005 16.7 2.5 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 24 family Prp19 PF08606.11 ORX52397.1 - 0.058 13.4 0.2 0.1 12.6 0.2 1.4 1 0 0 1 1 1 0 Prp19/Pso4-like ATF7IP_BD PF16788.5 ORX52397.1 - 0.066 13.3 3.2 0.079 13.1 3.2 1.1 1 0 0 1 1 1 0 ATF-interacting protein binding domain FAA_hydrolase_N PF09298.11 ORX52397.1 - 0.082 13.1 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal RNA_pol_Rpb2_6 PF00562.28 ORX52398.1 - 1.2e-127 426.2 0.0 1.7e-127 425.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ORX52398.1 - 1.2e-67 227.4 0.0 1.8e-67 226.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 ORX52398.1 - 2.8e-47 160.8 0.0 6.3e-47 159.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 ORX52398.1 - 3.8e-35 120.1 0.2 1.4e-34 118.3 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 ORX52398.1 - 4.5e-25 87.6 0.1 1e-24 86.5 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_4 PF04566.13 ORX52398.1 - 3.5e-24 84.9 0.3 8.3e-24 83.7 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 ORX52398.1 - 2.5e-23 82.4 0.1 8.6e-23 80.7 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 ORX52398.1 - 0.12 13.1 0.8 0.26 12.0 0.8 1.5 1 0 0 1 1 1 0 MRN-interacting protein DUF2318 PF10080.9 ORX52398.1 - 0.14 12.2 0.7 0.36 11.0 0.7 1.6 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Tti2 PF10521.9 ORX52399.1 - 2.4e-31 109.3 0.0 4.7e-31 108.4 0.0 1.4 1 0 0 1 1 1 1 Tti2 family RRM_4 PF10598.9 ORX52399.1 - 0.097 13.0 0.1 0.27 11.6 0.1 1.8 1 0 0 1 1 1 0 RNA recognition motif of the spliceosomal PrP8 WD40 PF00400.32 ORX52400.1 - 5e-55 182.2 23.1 1.2e-06 29.1 0.1 12.1 12 0 0 12 12 12 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX52400.1 - 1.8e-21 76.2 3.8 0.0074 16.6 0.0 8.1 4 2 3 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ORX52400.1 - 4.2e-18 65.6 0.4 8.6e-18 64.6 0.4 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 ORX52400.1 - 5.1e-06 26.0 0.0 3.2 7.0 0.0 4.6 4 1 0 4 4 4 2 WD40-like domain PALB2_WD40 PF16756.5 ORX52400.1 - 0.002 17.1 4.0 0.72 8.7 0.0 4.2 4 0 0 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ORX52400.1 - 0.0027 16.4 9.6 0.4 9.3 0.3 5.0 4 3 2 6 6 6 3 Nucleoporin Nup120/160 ELYS-bb PF16687.5 ORX52400.1 - 0.0069 15.0 0.0 0.02 13.5 0.0 1.7 2 0 0 2 2 2 1 beta-propeller of ELYS nucleoporin MFS_1 PF07690.16 ORX52401.1 - 2.5e-23 82.6 57.6 4.6e-13 48.8 26.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX52401.1 - 2e-08 33.2 31.8 3.2e-07 29.3 13.3 2.2 2 0 0 2 2 2 2 MFS/sugar transport protein Sugar_tr PF00083.24 ORX52401.1 - 0.00053 19.0 14.5 0.00053 19.0 14.5 2.9 1 1 0 2 2 2 1 Sugar (and other) transporter Mito_carr PF00153.27 ORX52402.1 - 3.7e-52 174.2 5.7 2.2e-18 66.0 0.0 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ORX52402.1 - 0.0011 18.1 0.1 0.12 11.6 0.1 2.3 2 1 0 2 2 2 2 Gammaproteobacterial serine protease SpoVAB PF13782.6 ORX52402.1 - 0.034 14.4 0.0 0.35 11.2 0.0 2.4 2 0 0 2 2 2 0 Stage V sporulation protein AB OrfB_Zn_ribbon PF07282.11 ORX52404.1 - 1.7e-07 31.1 0.1 2.4e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain SAPS PF04499.15 ORX52405.1 - 7.1e-123 411.0 3.5 1.8e-68 231.6 2.9 3.0 3 1 1 4 4 4 2 SIT4 phosphatase-associated protein Peptidase_M24 PF00557.24 ORX52406.1 - 1.3e-46 158.9 0.2 1.9e-46 158.4 0.2 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 ORX52406.1 - 0.02 14.6 0.0 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 Aminopeptidase P, N-terminal domain PLDc_2 PF13091.6 ORX52407.1 - 6.2e-25 87.6 0.8 1.2e-24 86.7 0.8 1.5 1 0 0 1 1 1 1 PLD-like domain FAM83 PF07894.12 ORX52407.1 - 0.00075 19.1 0.1 0.083 12.4 0.1 2.4 2 0 0 2 2 2 2 FAM83 A-H PLDc PF00614.22 ORX52407.1 - 0.0066 16.6 0.2 0.014 15.5 0.2 1.6 1 0 0 1 1 1 1 Phospholipase D Active site motif WD40 PF00400.32 ORX52409.1 - 0.0016 19.2 8.4 0.031 15.1 0.5 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Cnd2 PF05786.14 ORX52410.1 - 5.6e-154 514.7 21.5 7.8e-154 514.3 21.5 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 ORX52410.1 - 0.025 14.8 0.1 0.099 12.9 0.0 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal MotA_ExbB PF01618.16 ORX52411.1 - 4.5 7.0 4.9 15 5.3 0.2 2.9 2 1 1 3 3 3 0 MotA/TolQ/ExbB proton channel family 3HCDH_N PF02737.18 ORX52412.1 - 9.5e-62 208.1 1.1 1.5e-61 207.4 1.1 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ORX52412.1 - 9e-34 116.0 0.5 8.4e-33 112.9 0.1 2.5 3 0 0 3 3 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ORX52412.1 - 2.8e-05 24.3 3.3 0.00028 21.1 3.3 2.2 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 ORX52412.1 - 5.4e-05 22.6 2.5 0.0001 21.7 2.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 ORX52412.1 - 0.00013 21.3 0.2 0.00018 20.9 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_Gly3P_dh_N PF01210.23 ORX52412.1 - 0.00028 20.9 0.4 0.00049 20.1 0.4 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UDPG_MGDP_dh_N PF03721.14 ORX52412.1 - 0.00039 20.1 0.9 0.00081 19.0 0.9 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 ORX52412.1 - 0.00045 20.6 1.2 0.0008 19.8 1.2 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox PF00070.27 ORX52412.1 - 0.0006 20.3 0.2 0.0011 19.4 0.2 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase XdhC_C PF13478.6 ORX52412.1 - 0.0024 18.4 0.2 0.0038 17.7 0.2 1.4 1 0 0 1 1 1 1 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 ORX52412.1 - 0.0044 16.4 0.6 0.0091 15.4 0.1 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 ORX52412.1 - 0.0082 15.8 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Epimerase PF01370.21 ORX52412.1 - 0.01 15.3 0.2 0.014 14.9 0.2 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 ORX52412.1 - 0.063 13.3 1.1 0.16 12.0 1.1 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase TrkA_N PF02254.18 ORX52412.1 - 0.071 13.4 1.4 0.14 12.4 1.4 1.6 1 0 0 1 1 1 0 TrkA-N domain DAO PF01266.24 ORX52412.1 - 0.072 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 ORX52412.1 - 0.1 12.7 4.9 1.5 8.9 4.2 2.5 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_8 PF13450.6 ORX52412.1 - 0.11 12.7 0.7 0.25 11.6 0.7 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Methyltransf_12 PF08242.12 ORX52412.1 - 0.17 12.6 1.2 0.64 10.8 1.1 2.1 1 1 0 1 1 1 0 Methyltransferase domain GntR PF00392.21 ORX52412.1 - 0.2 11.3 0.3 1 9.0 0.0 2.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, gntR family Sacchrp_dh_NADP PF03435.18 ORX52412.1 - 0.27 11.5 3.9 0.86 9.9 3.9 1.9 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 ORX52412.1 - 0.38 10.3 4.9 0.6 9.6 4.9 1.3 1 0 0 1 1 1 0 NmrA-like family F420_oxidored PF03807.17 ORX52412.1 - 0.4 11.3 6.0 2.9 8.5 6.0 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent zf-primase PF09329.11 ORX52413.1 - 1.4e-07 31.2 0.9 2.6e-07 30.3 0.9 1.5 1 0 0 1 1 1 1 Primase zinc finger PEHE PF15275.6 ORX52413.1 - 0.076 13.6 0.3 0.15 12.7 0.3 1.4 1 0 0 1 1 1 0 PEHE domain FAM60A PF15396.6 ORX52413.1 - 0.78 9.7 7.0 0.26 11.2 2.6 2.0 2 1 0 2 2 2 0 Protein Family FAM60A Cyclin_N PF00134.23 ORX52414.1 - 1.5e-07 31.2 0.6 7e-07 29.0 0.2 2.3 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX52414.1 - 0.00013 22.4 0.0 0.00032 21.1 0.0 1.8 1 0 0 1 1 1 1 Cyclin RTTN_N PF14726.6 ORX52415.1 - 0.093 13.5 0.1 0.16 12.8 0.1 1.3 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning CNDH2_C PF16858.5 ORX52415.1 - 0.33 10.8 10.9 0.43 10.4 10.9 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Rhabdo_ncap PF00945.18 ORX52415.1 - 3.9 6.2 7.3 5.8 5.7 7.3 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF4460 PF14687.6 ORX52416.1 - 1.7e-08 34.5 0.2 4.5e-08 33.1 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4460) DnaJ PF00226.31 ORX52416.1 - 0.052 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 DnaJ domain SH3_1 PF00018.28 ORX52418.1 - 6.5e-38 128.1 8.1 6.9e-16 57.6 0.4 3.5 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 ORX52418.1 - 1.1e-32 111.6 11.0 1e-14 54.1 0.4 3.9 4 0 0 4 4 4 3 Variant SH3 domain SHD1 PF03983.12 ORX52418.1 - 4.6e-30 103.2 0.1 8.6e-30 102.4 0.1 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 ORX52418.1 - 5.9e-27 93.1 0.3 1.4e-11 43.9 0.1 3.4 3 0 0 3 3 3 3 Variant SH3 domain Caldesmon PF02029.15 ORX52418.1 - 0.00011 21.2 9.8 0.00011 21.2 9.8 2.8 2 1 0 2 2 2 1 Caldesmon PH_6 PF15406.6 ORX52418.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain DUF2973 PF11189.8 ORX52418.1 - 0.49 10.5 2.1 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) Ribosomal_L37 PF08561.10 ORX52419.1 - 1.4e-22 80.5 5.4 2.2e-20 73.4 0.7 2.0 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 AA_permease PF00324.21 ORX52420.1 - 5.4e-129 430.9 49.9 6.7e-129 430.6 49.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX52420.1 - 1.1e-44 153.0 51.2 1.4e-44 152.6 51.2 1.1 1 0 0 1 1 1 1 Amino acid permease Thiolase_N PF00108.23 ORX52421.1 - 2.3e-20 73.1 0.2 1.9e-18 66.7 0.1 2.7 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX52421.1 - 4.7e-11 42.4 0.0 1.6e-10 40.7 0.0 2.0 1 1 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 ORX52421.1 - 0.0003 20.6 0.4 0.12 12.2 0.3 2.6 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 ORX52421.1 - 0.00061 19.8 0.4 0.019 15.0 0.0 3.0 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain SpoVAD PF07451.11 ORX52421.1 - 0.0007 18.4 0.3 0.17 10.6 0.1 2.5 2 1 1 3 3 3 2 Stage V sporulation protein AD (SpoVAD) ketoacyl-synt PF00109.26 ORX52421.1 - 0.0012 18.5 4.5 0.067 12.8 1.4 2.9 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain HMG_CoA_synt_N PF01154.17 ORX52421.1 - 0.026 14.4 0.1 0.062 13.2 0.1 1.6 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal DUF3808 PF10300.9 ORX52422.1 - 3.9e-81 273.2 1.5 1.7e-57 195.2 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3808) TPR_8 PF13181.6 ORX52422.1 - 0.017 15.3 0.0 0.14 12.4 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX52422.1 - 0.024 14.9 0.2 0.024 14.9 0.2 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX52422.1 - 0.081 13.1 5.5 0.82 9.9 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX52422.1 - 0.082 12.8 0.1 0.082 12.8 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX52422.1 - 0.13 12.4 2.2 0.29 11.2 0.2 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX52422.1 - 0.27 12.2 3.8 2.9 8.9 0.2 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF755 PF05501.11 ORX52422.1 - 6.4 7.1 18.3 1.8 8.9 0.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF755) RhoGEF PF00621.20 ORX52423.1 - 7e-33 114.4 1.5 1.3e-32 113.5 0.4 1.9 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ORX52423.1 - 3.4e-06 27.5 0.1 1e-05 25.9 0.1 1.9 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ORX52423.1 - 0.013 15.3 0.1 0.56 10.0 0.1 2.5 1 1 0 1 1 1 0 Pleckstrin homology domain RRP7 PF12923.7 ORX52424.1 - 1.2e-31 109.4 17.3 1.7e-31 108.8 15.0 2.2 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 ORX52424.1 - 1.4e-13 51.0 0.1 3.4e-13 49.7 0.0 1.7 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRM_1 PF00076.22 ORX52424.1 - 0.023 14.5 0.0 0.097 12.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nnf1 PF03980.14 ORX52424.1 - 1.5 9.3 6.1 0.47 10.9 1.7 2.2 2 1 0 2 2 2 0 Nnf1 TruD PF01142.18 ORX52425.1 - 0.027 13.3 0.5 0.17 10.7 0.3 1.9 1 1 1 2 2 2 0 tRNA pseudouridine synthase D (TruD) TRAF_BIRC3_bd PF16673.5 ORX52425.1 - 0.042 13.6 3.2 0.13 12.1 0.4 2.8 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain RRM_1 PF00076.22 ORX52425.1 - 0.14 12.0 0.0 0.62 9.9 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDA1 PF05285.12 ORX52426.1 - 8.8e-83 278.6 40.2 8.8e-83 278.6 40.2 2.2 2 0 0 2 2 2 2 SDA1 NUC130_3NT PF08158.12 ORX52426.1 - 1e-24 86.6 1.0 2.9e-24 85.1 1.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain TGT PF01702.18 ORX52427.1 - 6.9e-149 495.7 0.0 8.1e-149 495.5 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase SinI PF08671.10 ORX52428.1 - 0.15 11.9 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Anti-repressor SinI Fcf1 PF04900.12 ORX52429.1 - 1.1e-39 134.8 1.4 1.4e-39 134.4 1.4 1.2 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 ORX52429.1 - 2.2e-11 44.1 0.0 3.2e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 PIN like domain DUF116 PF01976.17 ORX52429.1 - 0.017 14.6 0.7 0.023 14.2 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF116 DNA_ligase_OB_2 PF14743.6 ORX52430.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 DNA ligase OB-like domain Coq4 PF05019.13 ORX52431.1 - 2.8e-34 118.4 0.0 3.5e-34 118.1 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Crr6 PF08847.11 ORX52432.1 - 0.015 15.0 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 Chlororespiratory reduction 6 NAD_binding_10 PF13460.6 ORX52433.1 - 4.8e-10 39.6 0.0 7e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX52433.1 - 1.6e-05 24.5 0.0 2e-05 24.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ORX52433.1 - 0.00029 21.1 0.1 0.00044 20.5 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Semialdhyde_dh PF01118.24 ORX52433.1 - 0.0024 18.3 0.0 0.0044 17.5 0.0 1.8 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NmrA PF05368.13 ORX52433.1 - 0.012 15.1 0.2 0.018 14.6 0.2 1.4 1 1 0 1 1 1 0 NmrA-like family NAD_binding_4 PF07993.12 ORX52433.1 - 0.014 14.6 0.0 0.54 9.4 0.0 2.2 2 0 0 2 2 2 0 Male sterility protein KR PF08659.10 ORX52433.1 - 0.096 12.6 0.1 0.14 12.0 0.1 1.4 1 1 0 1 1 1 0 KR domain RhoGAP PF00620.27 ORX52434.1 - 1.4e-48 164.6 0.7 3.6e-48 163.2 0.0 2.1 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 ORX52434.1 - 1.7e-14 53.8 33.5 4.3e-08 33.3 7.7 3.6 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 ORX52434.1 - 4.2e-08 33.0 5.7 4.2e-08 33.0 5.7 4.4 3 1 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) TraG_N PF07916.11 ORX52434.1 - 0.21 10.4 8.2 30 3.3 8.2 2.4 1 1 0 1 1 1 0 TraG-like protein, N-terminal region Suppressor_APC PF11414.8 ORX52434.1 - 0.72 10.0 6.8 0.098 12.7 0.6 2.8 3 0 0 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Paired_CXXCH_1 PF09699.10 ORX52434.1 - 2.1 8.2 16.3 3.4 7.5 3.7 3.4 2 1 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF5434 PF17502.2 ORX52434.1 - 3.8 7.5 9.5 4.4 7.2 1.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5434) TMF_TATA_bd PF12325.8 ORX52434.1 - 4.6 7.5 30.2 0.028 14.6 2.8 4.5 3 1 2 5 5 5 0 TATA element modulatory factor 1 TATA binding SBDS PF01172.18 ORX52435.1 - 1.4e-16 60.4 0.0 1.6e-16 60.2 0.0 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SKA1 PF07160.12 ORX52436.1 - 0.0035 17.2 0.7 0.0035 17.2 0.7 2.4 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 1 KxDL PF10241.9 ORX52436.1 - 0.0071 16.6 2.7 0.0071 16.6 2.7 2.2 2 1 0 2 2 2 1 Uncharacterized conserved protein LMP PF04778.12 ORX52436.1 - 0.012 15.6 4.3 0.03 14.3 4.3 1.8 1 0 0 1 1 1 0 LMP repeated region DUF2019 PF09450.10 ORX52436.1 - 0.045 13.7 0.7 0.11 12.4 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF2019) HTH_Tnp_Mu_1 PF02316.16 ORX52436.1 - 0.099 12.8 0.2 0.27 11.4 0.2 1.7 1 0 0 1 1 1 0 Mu DNA-binding domain FapA PF03961.13 ORX52436.1 - 0.2 10.2 3.7 0.38 9.3 3.7 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A CdvA PF18822.1 ORX52436.1 - 0.46 10.3 15.1 17 5.2 13.5 3.1 2 1 0 2 2 2 0 CdvA-like coiled-coil domain zf-C4H2 PF10146.9 ORX52436.1 - 0.7 10.2 12.5 2.2 8.5 12.4 1.8 1 1 0 1 1 1 0 Zinc finger-containing protein DUF4407 PF14362.6 ORX52436.1 - 0.84 8.9 3.3 1.4 8.2 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LRRFIP PF09738.9 ORX52436.1 - 4.8 6.6 16.7 0.71 9.3 12.1 1.8 1 1 0 1 1 1 0 LRRFIP family CorA PF01544.18 ORX52436.1 - 5.7 6.2 10.9 1.3 8.3 6.6 1.8 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Importin_rep_4 PF18808.1 ORX52437.1 - 5.6e-32 109.9 11.3 6.7e-32 109.6 0.4 5.1 5 1 1 6 6 5 1 Importin repeat HEAT_EZ PF13513.6 ORX52437.1 - 1.1e-14 54.6 5.0 2.7e-06 27.7 0.0 8.4 7 1 1 8 8 8 2 HEAT-like repeat HEAT_2 PF13646.6 ORX52437.1 - 5.2e-14 52.4 2.6 0.00012 22.4 0.0 7.4 5 2 5 10 10 9 4 HEAT repeats Importin_rep_6 PF18829.1 ORX52437.1 - 3.1e-13 49.8 1.6 9.8e-13 48.2 0.0 2.7 3 0 0 3 3 3 1 Importin repeat 6 HEAT PF02985.22 ORX52437.1 - 4.9e-12 45.0 5.5 0.0041 17.2 0.0 9.1 11 0 0 11 11 10 2 HEAT repeat Vac14_Fab1_bd PF12755.7 ORX52437.1 - 2e-11 44.3 0.1 0.12 13.0 0.0 6.5 5 2 1 6 6 5 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 ORX52437.1 - 4.6e-10 39.6 4.6 0.017 15.1 0.9 6.8 4 2 1 5 5 5 2 Domain of unknown function (DUF3385) MMS19_C PF12460.8 ORX52437.1 - 5.4e-07 29.1 0.4 1.7 7.7 0.5 5.6 4 2 1 5 5 5 2 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 ORX52437.1 - 1.9e-05 24.4 2.4 0.29 10.7 0.2 5.5 6 1 1 7 7 7 1 CLASP N terminal RTP1_C1 PF10363.9 ORX52437.1 - 0.0081 16.3 2.0 0.15 12.2 0.2 3.9 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 ORX52437.1 - 0.0084 16.1 4.2 11 6.2 0.0 5.3 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 ORX52437.1 - 0.025 14.5 0.1 0.98 9.4 0.3 3.7 4 0 0 4 4 4 0 Importin-beta N-terminal domain V-ATPase_H_N PF03224.14 ORX52437.1 - 0.045 13.0 1.1 0.3 10.3 0.4 2.4 2 0 0 2 2 2 0 V-ATPase subunit H Sec7_N PF12783.7 ORX52437.1 - 0.058 13.3 0.0 11 5.8 0.0 3.3 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Glyco_transf_25 PF01755.17 ORX52437.1 - 0.071 13.0 0.2 0.14 12.0 0.2 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) RICTOR_V PF14668.6 ORX52437.1 - 0.14 12.4 0.0 1.8 8.9 0.0 3.0 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, domain 5 WD40 PF00400.32 ORX52438.1 - 6.6e-13 48.9 2.5 0.22 12.5 0.0 6.9 6 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX52438.1 - 4.8e-07 30.0 0.2 0.21 11.9 0.0 4.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX52438.1 - 0.00045 19.7 0.2 0.003 16.9 0.1 2.1 1 1 0 2 2 2 1 WD40-like domain YL1 PF05764.13 ORX52438.1 - 1 9.4 11.8 1.7 8.7 11.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ORX52438.1 - 1.1 7.5 12.4 1.9 6.7 12.4 1.3 1 0 0 1 1 1 0 CDC45-like protein SPOB_ab PF14682.6 ORX52439.1 - 0.088 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal Cu_amine_oxid PF01179.20 ORX52441.1 - 4.1e-14 52.3 0.3 4.8e-14 52.1 0.3 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxid PF01179.20 ORX52443.1 - 3.1e-128 428.2 0.1 3.8e-128 427.9 0.1 1.1 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 ORX52443.1 - 5.7e-15 55.5 0.0 1.3e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Cu_amine_oxidN2 PF02727.16 ORX52443.1 - 3.5e-09 36.8 0.2 9e-09 35.4 0.2 1.7 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain SGL PF08450.12 ORX52443.1 - 0.13 11.8 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Cu_amine_oxid PF01179.20 ORX52445.1 - 5.9e-06 25.5 0.1 7.9e-06 25.0 0.1 1.2 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain DOPA_dioxygen PF08883.11 ORX52446.1 - 1.3e-30 105.8 0.2 1.6e-30 105.4 0.2 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family FYRC PF05965.14 ORX52447.1 - 3.5e-20 72.0 0.0 6.9e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.14 ORX52447.1 - 7.7e-17 60.9 0.2 1.4e-16 60.1 0.2 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus GAS PF13851.6 ORX52447.1 - 0.04 13.3 1.9 0.064 12.6 1.9 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding NBP1 PF08537.10 ORX52447.1 - 0.057 12.8 2.6 0.12 11.8 2.6 1.5 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DUF4570 PF15134.6 ORX52447.1 - 0.078 13.0 0.8 0.16 12.0 0.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Fungal_TACC PF12709.7 ORX52447.1 - 0.11 12.9 1.4 0.2 12.2 1.4 1.3 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins Herpes_pp85 PF04637.12 ORX52447.1 - 0.15 10.5 0.1 0.31 9.4 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SR-25 PF10500.9 ORX52447.1 - 0.27 10.8 4.3 0.17 11.5 1.3 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ORX52449.1 - 6.1e-49 166.8 0.0 9e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52449.1 - 2e-28 99.4 0.0 2.9e-28 98.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX52449.1 - 0.0017 17.7 0.0 0.0094 15.3 0.0 2.2 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 ORX52449.1 - 0.062 13.2 0.2 0.62 9.9 0.0 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family HLH PF00010.26 ORX52450.1 - 1e-05 25.4 2.6 1.6e-05 24.7 1.3 2.0 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Ribosomal_L29 PF00831.23 ORX52450.1 - 0.42 10.6 6.0 0.16 12.0 1.1 2.6 2 0 0 2 2 2 0 Ribosomal L29 protein DUF848 PF05852.11 ORX52450.1 - 4.2 7.5 11.9 3 8.0 8.3 2.3 2 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) YjeF_N PF03853.15 ORX52451.1 - 1.6e-33 116.0 0.1 2.4e-33 115.4 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 ORX52451.1 - 1.9e-06 28.7 1.4 1.9e-06 28.7 1.4 2.4 1 1 1 2 2 2 1 FDF domain LSM14 PF12701.7 ORX52451.1 - 0.00036 20.6 0.0 0.00073 19.6 0.0 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain Ras PF00071.22 ORX52452.1 - 1.7e-55 187.1 0.1 2e-55 186.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX52452.1 - 7.1e-34 116.6 0.0 1.2e-33 115.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX52452.1 - 5.8e-18 65.0 0.0 7.8e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX52452.1 - 3.7e-07 29.7 0.0 4.7e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX52452.1 - 1.2e-06 28.2 0.1 2.8e-05 23.7 0.1 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX52452.1 - 1.9e-05 24.7 0.0 2.9e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX52452.1 - 0.00012 22.0 0.1 0.16 11.9 0.1 2.3 1 1 1 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX52452.1 - 0.00053 20.4 0.0 0.00078 19.9 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 ORX52452.1 - 0.0014 18.2 0.0 0.014 14.9 0.0 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_7 PF12775.7 ORX52452.1 - 0.0015 18.1 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region SRPRB PF09439.10 ORX52452.1 - 0.006 16.0 0.0 0.008 15.6 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ORX52452.1 - 0.007 16.2 0.1 0.034 13.9 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein ATPase PF06745.13 ORX52452.1 - 0.0098 15.3 0.1 0.037 13.4 0.0 1.8 1 1 0 2 2 2 1 KaiC AAA_22 PF13401.6 ORX52452.1 - 0.012 15.9 0.0 0.039 14.2 0.0 1.9 1 1 0 1 1 1 0 AAA domain Septin PF00735.18 ORX52452.1 - 0.013 14.8 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Septin TniB PF05621.11 ORX52452.1 - 0.016 14.6 0.0 0.041 13.3 0.0 1.8 1 1 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 ORX52452.1 - 0.022 14.5 0.0 0.11 12.2 0.0 1.8 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX52452.1 - 0.031 14.8 0.1 0.056 14.0 0.1 1.7 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 ORX52452.1 - 0.045 13.7 0.0 0.59 10.0 0.0 2.1 2 0 0 2 2 2 0 NACHT domain DAP3 PF10236.9 ORX52452.1 - 0.046 12.9 0.1 0.47 9.6 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 cobW PF02492.19 ORX52452.1 - 0.047 13.3 0.2 0.72 9.4 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 ORX52452.1 - 0.055 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ORX52452.1 - 0.093 12.7 0.1 0.21 11.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ORX52452.1 - 0.096 13.1 0.0 0.54 10.7 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Iso_dh PF00180.20 ORX52453.1 - 3e-78 263.4 0.0 3.7e-78 263.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase GTP_EFTU PF00009.27 ORX52454.1 - 3.5e-44 150.7 0.1 1.2e-43 148.9 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX52454.1 - 1.8e-33 115.2 0.1 7e-33 113.3 0.1 2.1 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX52454.1 - 6.4e-12 45.7 1.0 1.5e-11 44.5 1.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX52454.1 - 0.0026 17.8 0.1 0.021 14.9 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase Not3 PF04065.15 ORX52455.1 - 3.1e-92 308.2 31.8 4.9e-92 307.5 31.8 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 ORX52455.1 - 5.2e-47 159.2 10.5 2.5e-46 157.0 10.5 2.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family Yos9_DD PF17880.1 ORX52455.1 - 0.053 13.6 0.4 0.16 12.1 0.4 1.8 1 0 0 1 1 1 0 Yos9 dimerzation domain SesA PF17107.5 ORX52455.1 - 0.26 11.5 5.8 1.3 9.2 0.7 2.6 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF4407 PF14362.6 ORX52455.1 - 4.7 6.5 7.3 8.1 5.7 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Syntaxin_2 PF14523.6 ORX52455.1 - 5.1 7.5 15.1 0.75 10.2 4.6 2.9 3 0 0 3 3 3 0 Syntaxin-like protein Ribosomal_L12 PF00542.19 ORX52456.1 - 2.8e-21 75.6 10.0 2.8e-21 75.6 10.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 ORX52456.1 - 1.4e-16 59.9 1.6 1.4e-16 59.9 1.6 3.1 2 1 1 3 3 3 2 Ribosomal protein L7/L12 dimerisation domain DUF4479 PF14794.6 ORX52456.1 - 0.044 13.6 1.3 0.074 12.9 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4479) DUF2267 PF10025.9 ORX52456.1 - 0.058 13.7 0.2 0.17 12.1 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) Rho_GDI PF02115.17 ORX52457.1 - 3.5e-65 219.4 0.1 8.2e-65 218.2 0.1 1.5 1 1 0 1 1 1 1 RHO protein GDP dissociation inhibitor HA2 PF04408.23 ORX52458.1 - 4.2e-25 88.1 0.1 1.1e-24 86.7 0.1 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX52458.1 - 2.4e-20 72.7 0.0 7.5e-20 71.1 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX52458.1 - 1.3e-11 44.8 0.0 3.1e-11 43.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX52458.1 - 1.6e-08 34.5 0.0 3.9e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX52458.1 - 2.2e-06 28.0 0.1 8.1e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ORX52458.1 - 8.1e-05 23.0 0.0 0.00016 22.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX52458.1 - 0.0097 15.6 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ORX52458.1 - 0.01 15.5 0.1 0.024 14.2 0.1 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 ORX52458.1 - 0.017 15.6 0.0 0.04 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ORX52458.1 - 0.049 12.7 0.0 0.12 11.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 ORX52458.1 - 0.078 12.7 0.0 13 5.4 0.0 2.3 2 0 0 2 2 2 0 IstB-like ATP binding protein Dynamin_N PF00350.23 ORX52459.1 - 1.7e-43 148.6 0.0 1.7e-43 148.6 0.0 2.7 3 0 0 3 3 3 1 Dynamin family Dynamin_M PF01031.20 ORX52459.1 - 2.3e-19 69.7 1.0 2.5e-15 56.5 0.0 2.7 3 0 0 3 3 3 2 Dynamin central region MMR_HSR1 PF01926.23 ORX52459.1 - 1.4e-06 28.4 0.1 1.7e-05 24.9 0.0 2.8 2 2 0 2 2 2 1 50S ribosome-binding GTPase SMC_N PF02463.19 ORX52459.1 - 0.0017 17.8 0.5 1.6 8.1 0.0 2.7 3 0 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX52459.1 - 0.0018 18.1 0.0 0.02 14.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system NolV PF06635.12 ORX52459.1 - 0.0019 17.6 0.6 0.0058 16.0 0.0 2.0 2 0 0 2 2 2 1 Nodulation protein NolV Ribosomal_60s PF00428.19 ORX52459.1 - 0.054 14.1 5.0 0.14 12.7 5.0 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein RskA PF10099.9 ORX52459.1 - 0.071 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Roc PF08477.13 ORX52459.1 - 0.09 13.0 0.0 0.59 10.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 ORX52459.1 - 0.16 11.6 0.1 0.16 11.6 0.1 3.4 2 1 1 3 3 3 0 AAA ATPase domain IHABP4_N PF16174.5 ORX52459.1 - 0.26 11.9 6.6 0.33 11.6 3.4 2.3 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal PPR_2 PF13041.6 ORX52460.1 - 0.0025 17.9 0.4 0.0025 17.9 0.4 1.8 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ORX52460.1 - 0.0032 17.6 1.1 0.0092 16.2 1.1 1.8 1 0 0 1 1 1 1 PPR repeat BPL_N PF09825.9 ORX52462.1 - 4.6e-101 338.6 0.0 6.7e-101 338.1 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 ORX52462.1 - 3.4e-20 72.3 0.0 6e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family GATase_3 PF07685.14 ORX52462.1 - 0.0041 16.8 0.1 0.0083 15.7 0.1 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 ORX52462.1 - 0.015 15.1 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Glutamine amidotransferase class-I DJ-1_PfpI PF01965.24 ORX52462.1 - 0.11 12.3 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 DJ-1/PfpI family Heme_oxygenase PF01126.20 ORX52463.1 - 5.8e-56 189.5 0.2 7e-56 189.3 0.2 1.1 1 0 0 1 1 1 1 Heme oxygenase DPBB_1 PF03330.18 ORX52465.1 - 4.1e-06 27.0 0.1 8.2e-06 26.0 0.1 1.5 1 0 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX52465.1 - 0.046 13.6 0.2 0.069 13.0 0.2 1.2 1 0 0 1 1 1 0 Barwin family MRP-L20 PF12824.7 ORX52465.1 - 0.19 11.9 0.4 0.26 11.4 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 FAD_binding_4 PF01565.23 ORX52466.1 - 5.5e-15 55.3 0.4 1.4e-14 54.0 0.2 1.8 1 1 1 2 2 2 1 FAD binding domain BBE PF08031.12 ORX52466.1 - 3.7e-12 46.1 0.2 6.7e-12 45.3 0.2 1.4 1 0 0 1 1 1 1 Berberine and berberine like Herpes_heli_pri PF05774.11 ORX52466.1 - 0.066 13.4 0.3 23 5.2 0.0 3.0 2 1 1 3 3 3 0 Herpesvirus helicase-primase complex component PEX11 PF05648.14 ORX52467.1 - 1.6e-52 178.2 0.6 1.8e-52 178.0 0.6 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) COR PF16095.5 ORX52467.1 - 0.0025 17.6 0.1 0.0047 16.8 0.0 1.6 2 1 0 2 2 2 1 C-terminal of Roc, COR, domain ATP-synt_DE PF00401.20 ORX52467.1 - 0.47 10.7 2.7 3.1 8.1 3.0 2.0 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain Apolipoprotein PF01442.18 ORX52468.1 - 2.6e-05 24.2 13.6 0.048 13.5 1.3 3.1 2 1 0 2 2 2 2 Apolipoprotein A1/A4/E domain PCI PF01399.27 ORX52468.1 - 3.4e-05 24.3 3.2 0.00078 19.9 0.2 2.7 2 1 0 2 2 2 1 PCI domain DUF1280 PF06918.14 ORX52468.1 - 0.0016 18.0 2.9 0.82 9.2 0.4 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1280) PPDFL PF15060.6 ORX52468.1 - 0.0093 16.5 0.3 0.36 11.4 0.0 2.8 2 1 0 3 3 3 1 Differentiation and proliferation regulator CENP-H PF05837.12 ORX52468.1 - 0.017 15.5 10.6 0.45 11.0 0.4 2.8 3 0 0 3 3 3 0 Centromere protein H (CENP-H) cwf21 PF08312.12 ORX52468.1 - 0.024 14.8 1.1 5.2 7.3 0.2 3.3 3 0 0 3 3 3 0 cwf21 domain TetR_C_7 PF14246.6 ORX52468.1 - 0.043 13.8 0.9 0.62 10.1 0.1 2.6 2 0 0 2 2 2 0 AefR-like transcriptional repressor, C-terminal domain UPF0515 PF15135.6 ORX52468.1 - 0.36 10.2 3.8 0.26 10.6 2.1 1.6 1 1 1 2 2 2 0 Uncharacterised protein UPF0515 BAR_3 PF16746.5 ORX52468.1 - 0.4 10.4 7.1 4.7 6.8 0.1 2.5 2 0 0 2 2 2 0 BAR domain of APPL family YtxH PF12732.7 ORX52468.1 - 0.53 10.8 4.5 20 5.8 1.3 3.3 2 2 0 2 2 2 0 YtxH-like protein DUF883 PF05957.13 ORX52468.1 - 0.6 10.8 14.4 17 6.1 0.0 4.5 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF883) DUF5082 PF16888.5 ORX52468.1 - 0.63 10.3 8.0 0.92 9.8 2.8 2.9 3 1 0 3 3 2 0 Domain of unknown function (DUF5082) Laminin_II PF06009.12 ORX52468.1 - 1.5 8.8 9.1 2.4 8.2 1.5 2.4 2 0 0 2 2 2 0 Laminin Domain II FliG_N PF14842.6 ORX52468.1 - 1.9 9.0 5.1 6.7 7.3 0.5 3.7 2 2 2 4 4 4 0 FliG N-terminal domain DUF1451 PF07295.11 ORX52468.1 - 3.4 7.7 14.4 2.1 8.4 0.1 4.1 2 2 1 4 4 4 0 Zinc-ribbon containing domain Fib_alpha PF08702.10 ORX52468.1 - 5.3 7.2 11.8 7.6 6.7 1.8 3.0 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family ApoO PF09769.9 ORX52468.1 - 9.2 6.2 8.6 6.6 6.7 0.2 3.7 2 2 2 4 4 4 0 Apolipoprotein O FA_desaturase PF00487.24 ORX52469.1 - 3.4e-17 63.1 23.2 5.4e-17 62.5 23.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ORX52469.1 - 1.5e-14 53.9 0.0 4.7e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain UPRTase PF14681.6 ORX52470.1 - 0.068 12.6 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Homeobox_KN PF05920.11 ORX52471.1 - 6.8e-19 67.5 1.6 2.1e-18 66.0 1.6 1.9 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX52471.1 - 6.6e-06 25.9 0.5 2e-05 24.3 0.5 1.9 1 0 0 1 1 1 1 Homeodomain Wbp11 PF09429.10 ORX52472.1 - 3.4e-22 78.6 13.8 3.4e-22 78.6 13.8 2.8 3 0 0 3 3 3 1 WW domain binding protein 11 DUF4404 PF14357.6 ORX52472.1 - 0.013 16.1 3.6 0.013 16.1 3.6 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) Fib_alpha PF08702.10 ORX52472.1 - 0.013 15.7 0.5 0.037 14.2 0.5 1.7 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TRIQK PF15168.6 ORX52472.1 - 0.67 9.9 2.2 1.3 8.9 2.2 1.5 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family CorA PF01544.18 ORX52472.1 - 0.97 8.7 2.8 1.5 8.0 2.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Prefoldin_2 PF01920.20 ORX52472.1 - 1.5 8.9 11.0 0.36 10.8 7.7 1.7 2 0 0 2 2 2 0 Prefoldin subunit NTF2 PF02136.20 ORX52473.1 - 3.9e-25 88.7 0.1 4.4e-25 88.6 0.1 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 ORX52473.1 - 2.1e-05 24.5 0.0 2.5e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 Sugar_tr PF00083.24 ORX52474.1 - 1.5e-55 188.9 23.3 1.9e-55 188.6 23.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX52474.1 - 2.3e-24 86.0 24.0 2.8e-17 62.7 13.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily NT5C PF06941.12 ORX52475.1 - 3.4e-07 30.3 0.2 4.5e-06 26.7 0.2 2.5 2 1 0 2 2 2 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_2 PF13419.6 ORX52475.1 - 0.081 13.0 0.0 0.19 11.8 0.0 1.6 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase NIR_SIR PF01077.22 ORX52477.1 - 2.1e-51 173.6 0.0 4.5e-44 149.8 0.0 2.5 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain Flavodoxin_1 PF00258.25 ORX52477.1 - 3.4e-33 114.9 0.1 1e-32 113.3 0.0 2.0 2 0 0 2 2 2 1 Flavodoxin NIR_SIR_ferr PF03460.17 ORX52477.1 - 3.2e-25 87.8 0.0 6.2e-14 51.6 0.0 2.7 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain POR_N PF01855.19 ORX52477.1 - 5.1e-15 55.8 0.4 1e-14 54.8 0.4 1.4 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg PFOR_II PF17147.4 ORX52477.1 - 6.1e-09 36.1 0.1 3e-08 33.9 0.0 2.3 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II Flavodoxin_5 PF12724.7 ORX52477.1 - 0.069 13.4 0.0 0.17 12.1 0.0 1.7 1 0 0 1 1 1 0 Flavodoxin domain Sep15_SelM PF08806.11 ORX52477.1 - 0.07 13.3 0.0 0.45 10.7 0.0 2.4 2 0 0 2 2 2 0 Sep15/SelM redox domain PPDK_N PF01326.19 ORX52477.1 - 0.074 12.3 0.6 0.14 11.4 0.6 1.3 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain T3SS_needle_F PF09392.10 ORX52477.1 - 0.075 13.2 0.6 0.2 11.9 0.0 2.0 2 0 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF3203 PF11462.8 ORX52477.1 - 0.13 12.5 0.3 1.2 9.3 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3203) CedA PF10729.9 ORX52478.1 - 0.088 12.7 0.0 0.41 10.5 0.0 2.0 2 0 0 2 2 2 0 Cell division activator CedA Phage_HK97_TLTM PF06120.11 ORX52478.1 - 0.34 10.1 3.5 0.44 9.7 3.5 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Y_phosphatase3 PF13350.6 ORX52480.1 - 4.6e-30 105.3 0.0 5.5e-30 105.1 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ORX52480.1 - 1.3e-07 31.4 0.0 1.9e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX52480.1 - 8.3e-05 22.3 0.0 0.00011 21.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Myotub-related PF06602.14 ORX52480.1 - 0.048 12.6 0.0 0.066 12.1 0.0 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain DSPc PF00782.20 ORX52480.1 - 0.091 12.6 0.0 0.28 11.0 0.0 1.7 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Protoglobin PF11563.8 ORX52481.1 - 5.4e-43 146.6 0.0 6.3e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 Protoglobin PhoLip_ATPase_C PF16212.5 ORX52482.1 - 1.5e-83 280.4 25.2 1.5e-83 280.4 25.2 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX52482.1 - 3.5e-24 84.3 3.6 1.4e-23 82.3 3.6 2.2 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ORX52482.1 - 7.2e-13 49.3 0.6 2.1e-05 24.9 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX52482.1 - 2.4e-11 43.6 0.0 1.2e-10 41.3 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ORX52482.1 - 2.4e-09 37.0 0.0 2.4e-09 37.0 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX52482.1 - 0.0003 20.6 0.0 0.0038 17.0 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase adh_short_C2 PF13561.6 ORX52483.1 - 1.2e-55 188.7 1.6 1.3e-55 188.5 1.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX52483.1 - 1.8e-53 180.9 1.7 2.2e-53 180.6 1.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX52483.1 - 2.5e-17 63.4 5.2 5.4e-17 62.3 2.3 2.0 1 1 1 2 2 2 1 KR domain Epimerase PF01370.21 ORX52483.1 - 1.2e-08 34.8 1.2 2.1e-05 24.1 0.6 2.1 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ORX52483.1 - 2.9e-05 23.3 0.5 4.3e-05 22.8 0.5 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ORX52483.1 - 0.00067 19.2 0.7 0.013 14.9 0.7 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 ORX52483.1 - 0.0038 17.5 2.0 0.004 17.4 0.4 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain SRP54 PF00448.22 ORX52483.1 - 0.014 15.1 0.4 0.02 14.5 0.4 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain 3HCDH_N PF02737.18 ORX52483.1 - 0.044 13.7 0.3 0.076 12.9 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ORX52483.1 - 0.046 13.6 0.3 0.081 12.8 0.3 1.6 1 1 0 1 1 1 0 NAD(P)H-binding RsgA_GTPase PF03193.16 ORX52483.1 - 0.063 13.2 0.1 0.096 12.6 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase RmlD_sub_bind PF04321.17 ORX52483.1 - 0.068 12.3 0.2 0.11 11.5 0.2 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain GST_N_3 PF13417.6 ORX52484.1 - 1.2e-12 48.0 0.0 3.9e-12 46.4 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX52484.1 - 1.1e-10 41.6 0.9 3.6e-10 40.0 0.1 2.1 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX52484.1 - 9e-08 32.0 0.4 2.4e-07 30.7 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX52484.1 - 2.6e-06 27.7 0.0 5.7e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX52484.1 - 3.6e-06 27.1 0.0 7.5e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX52484.1 - 0.011 15.8 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ORX52484.1 - 0.018 14.9 0.1 0.04 13.7 0.1 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain SET PF00856.28 ORX52485.1 - 2.2e-08 34.7 0.1 6e-08 33.2 0.0 1.8 2 0 0 2 2 2 1 SET domain PBP1_TM PF14812.6 ORX52485.1 - 7.3 7.0 8.6 0.14 12.5 0.4 2.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glu_synthase PF01645.17 ORX52488.1 - 9.9e-156 518.5 0.3 6.4e-155 515.8 0.0 2.3 3 0 0 3 3 3 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 ORX52488.1 - 1.2e-103 346.4 0.0 8.5e-103 343.7 0.0 2.0 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 ORX52488.1 - 1.3e-85 285.8 1.9 2.3e-85 285.0 1.9 1.4 1 0 0 1 1 1 1 GXGXG motif GATase_2 PF00310.21 ORX52488.1 - 2.9e-72 243.7 0.0 4.1e-72 243.2 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Pyr_redox_2 PF07992.14 ORX52488.1 - 8.5e-26 90.8 0.0 3.1e-25 89.0 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 ORX52488.1 - 6.9e-23 80.6 0.0 1.5e-22 79.5 0.0 1.6 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_3 PF13738.6 ORX52488.1 - 8.6e-08 31.8 0.9 0.0032 16.8 0.0 3.7 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX52488.1 - 3e-07 30.6 0.0 1e-06 28.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ORX52488.1 - 3e-07 30.9 0.1 0.00012 22.5 0.0 3.0 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX52488.1 - 2.7e-06 27.2 0.2 0.0047 16.6 0.0 2.7 2 0 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX52488.1 - 0.00032 19.5 0.8 0.00084 18.1 0.1 2.0 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_7 PF13241.6 ORX52488.1 - 0.00088 19.7 0.0 0.92 10.0 0.0 2.8 2 0 0 2 2 2 1 Putative NAD(P)-binding Amino_oxidase PF01593.24 ORX52488.1 - 0.0021 17.5 0.0 0.004 16.5 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase 2-Hacid_dh_C PF02826.19 ORX52488.1 - 0.014 14.7 0.0 0.092 12.1 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ORX52488.1 - 0.018 15.2 0.1 0.062 13.5 0.1 2.0 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_binding_2 PF00890.24 ORX52488.1 - 0.019 14.1 0.0 0.019 14.1 0.0 3.0 4 0 0 4 4 3 0 FAD binding domain FAD_binding_3 PF01494.19 ORX52488.1 - 0.022 14.0 0.0 0.054 12.7 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 ORX52488.1 - 0.028 14.4 0.1 0.11 12.5 0.0 2.2 2 0 0 2 2 1 0 FAD-NAD(P)-binding NAD_Gly3P_dh_N PF01210.23 ORX52488.1 - 0.032 14.2 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Lycopene_cycl PF05834.12 ORX52488.1 - 0.064 12.3 0.0 0.15 11.1 0.0 1.6 1 0 0 1 1 1 0 Lycopene cyclase protein 3HCDH_N PF02737.18 ORX52488.1 - 0.082 12.8 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX52488.1 - 0.1 12.7 0.1 10 6.2 0.0 3.0 2 1 1 3 3 3 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 ORX52488.1 - 0.11 11.8 0.0 0.25 10.6 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase TrkA_N PF02254.18 ORX52488.1 - 0.13 12.6 0.2 0.7 10.2 0.0 2.3 2 0 0 2 2 2 0 TrkA-N domain GIDA PF01134.22 ORX52488.1 - 0.14 11.2 0.5 6.3 5.8 0.0 2.9 2 1 1 3 3 3 0 Glucose inhibited division protein A F420_oxidored PF03807.17 ORX52488.1 - 0.16 12.6 1.3 0.49 11.0 0.2 2.5 2 1 0 2 2 1 0 NADP oxidoreductase coenzyme F420-dependent Thi4 PF01946.17 ORX52488.1 - 0.23 10.7 2.9 0.74 9.0 0.0 3.0 4 0 0 4 4 4 0 Thi4 family FMN_dh PF01070.18 ORX52488.1 - 0.24 10.4 5.2 2.5 7.0 1.1 3.1 3 0 0 3 3 3 0 FMN-dependent dehydrogenase Response_reg PF00072.24 ORX52489.1 - 8.5e-22 77.4 0.1 1e-21 77.2 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain UFD1 PF03152.14 ORX52490.1 - 3.1e-40 137.5 0.0 6e-40 136.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 ORX52490.1 - 0.003 17.3 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 YcgL PF05166.13 ORX52491.1 - 0.14 12.5 0.2 3.5 8.1 0.1 2.4 2 0 0 2 2 2 0 YcgL domain Filament PF00038.21 ORX52659.1 - 0.0046 16.6 18.7 0.0046 16.6 18.7 2.4 2 0 0 2 2 2 1 Intermediate filament protein Tup_N PF08581.10 ORX52659.1 - 0.0099 16.2 9.1 0.0099 16.2 9.1 3.6 3 0 0 3 3 3 1 Tup N-terminal Kinesin PF00225.23 ORX52660.1 - 4.7e-104 347.9 0.4 1.9e-103 345.9 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX52660.1 - 1.3e-25 90.1 0.0 2.9e-25 88.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding GAS PF13851.6 ORX52660.1 - 0.037 13.4 5.4 0.064 12.6 5.4 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PRKG1_interact PF15898.5 ORX52660.1 - 0.04 14.8 5.8 0.88 10.5 1.6 2.5 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain SlyX PF04102.12 ORX52660.1 - 0.074 13.7 1.6 0.25 12.0 1.6 2.0 1 0 0 1 1 1 0 SlyX XPC-binding PF09280.11 ORX52660.1 - 0.096 12.4 1.1 0.34 10.7 1.1 1.9 1 0 0 1 1 1 0 XPC-binding domain KLRAQ PF10205.9 ORX52660.1 - 0.11 12.7 3.3 0.24 11.6 3.3 1.5 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein DUF3450 PF11932.8 ORX52660.1 - 0.17 11.2 9.3 0.12 11.6 6.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) AAA_24 PF13479.6 ORX52660.1 - 0.18 11.5 2.4 0.68 9.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain Nnf1 PF03980.14 ORX52660.1 - 0.19 12.2 4.4 0.36 11.2 4.4 1.5 1 0 0 1 1 1 0 Nnf1 ZapB PF06005.12 ORX52660.1 - 0.65 10.5 8.4 14 6.2 8.0 2.9 2 1 0 2 2 2 0 Cell division protein ZapB DUF87 PF01935.17 ORX52660.1 - 3.1 7.8 8.5 3.8 7.5 0.8 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain DUF1654 PF07867.11 ORX52662.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) PS_Dcarbxylase PF02666.15 ORX52663.1 - 0.17 11.4 0.0 0.39 10.2 0.0 1.7 1 1 1 2 2 2 0 Phosphatidylserine decarboxylase VPS53_C PF16854.5 ORX52664.1 - 0.025 14.5 0.5 0.043 13.7 0.5 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus Baseplate PF16774.5 ORX52664.1 - 0.073 13.0 0.5 0.25 11.3 0.6 1.8 2 0 0 2 2 2 0 Baseplate protein DUF3605 PF12239.8 ORX52665.1 - 5.2e-24 85.3 0.3 3.4e-22 79.4 0.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3605) S10_plectin PF03501.15 ORX52665.1 - 0.034 14.2 0.0 0.082 13.0 0.0 1.6 2 0 0 2 2 2 0 Plectin/S10 domain zf-C3HC4 PF00097.25 ORX52666.1 - 4.1e-09 36.2 10.7 8.2e-09 35.2 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX52666.1 - 6.6e-07 29.1 10.9 1.3e-06 28.1 10.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX52666.1 - 8.9e-07 29.1 11.9 8.9e-07 29.1 11.9 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX52666.1 - 1.5e-06 27.9 12.1 2.8e-06 27.0 12.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX52666.1 - 5.9e-06 26.2 9.5 5.9e-06 26.2 9.5 1.6 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX52666.1 - 1.2e-05 25.2 11.5 3.5e-05 23.7 11.5 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX52666.1 - 7.8e-05 22.9 10.2 0.00019 21.7 10.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ORX52666.1 - 0.00013 21.7 11.5 0.00024 20.9 11.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX52666.1 - 0.00014 21.9 6.8 0.00023 21.2 6.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ORX52666.1 - 0.00015 21.8 12.4 0.00032 20.8 12.4 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 ORX52666.1 - 0.00016 21.6 9.1 0.00031 20.7 9.1 1.4 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_4 PF14570.6 ORX52666.1 - 4.6 7.1 11.8 0.91 9.4 7.1 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Peptidase_U57 PF05582.12 ORX52667.1 - 0.062 12.6 0.0 1.2 8.4 0.0 2.1 1 1 0 2 2 2 0 YabG peptidase U57 WD40 PF00400.32 ORX52668.1 - 3.3e-38 129.0 13.6 3e-08 34.2 0.2 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat WD40_like PF17005.5 ORX52668.1 - 7.4e-11 41.9 0.3 3.2e-06 26.7 0.1 3.0 2 1 1 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 ORX52668.1 - 1.1e-10 41.6 0.8 0.43 10.9 0.0 5.8 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ORX52668.1 - 3.8e-06 26.7 0.0 4.9e-05 23.0 0.0 2.3 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 ORX52668.1 - 0.0026 16.5 3.0 13 4.2 0.1 4.3 2 1 2 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ORX52668.1 - 0.0033 16.4 0.1 5.1 5.9 0.0 3.6 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain BAT PF15915.5 ORX52668.1 - 0.0097 15.8 0.0 0.024 14.5 0.0 1.7 2 0 0 2 2 2 1 GAF and HTH_10 associated domain NUP214 PF16755.5 ORX52668.1 - 0.016 14.5 0.1 0.021 14.1 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 PQQ PF01011.21 ORX52668.1 - 0.038 13.9 0.0 1.9 8.6 0.0 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5046 PF16465.5 ORX52668.1 - 0.074 12.5 0.1 0.4 10.1 0.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5046) RINGv PF12906.7 ORX52669.1 - 2.6e-15 56.3 8.7 2.6e-15 56.3 8.7 2.1 2 0 0 2 2 2 1 RING-variant domain zf-RING_2 PF13639.6 ORX52669.1 - 0.054 13.8 10.2 0.12 12.7 10.2 1.7 1 0 0 1 1 1 0 Ring finger domain DUF4381 PF14316.6 ORX52669.1 - 0.33 11.2 3.5 2 8.7 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Glyco_hydro_9 PF00759.19 ORX52671.1 - 3.5e-111 372.6 15.1 4.2e-111 372.3 15.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 9 DUF2207 PF09972.9 ORX52671.1 - 0.04 12.7 0.0 0.056 12.2 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PSDC PF12588.8 ORX52671.1 - 0.062 13.3 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Phophatidylserine decarboxylase BCNT PF07572.12 ORX52672.1 - 3.5e-20 71.8 1.8 4e-20 71.7 1.8 1.1 1 0 0 1 1 1 1 Bucentaur or craniofacial development YL1 PF05764.13 ORX52673.1 - 0.047 13.8 14.5 0.054 13.6 14.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein DUF1018 PF06252.12 ORX52673.1 - 0.12 13.4 3.3 0.16 12.9 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) SPT6_acidic PF14632.6 ORX52673.1 - 0.8 10.3 15.7 2.9 8.5 15.7 1.9 1 1 0 1 1 1 0 Acidic N-terminal SPT6 CDC45 PF02724.14 ORX52673.1 - 1.9 6.7 12.3 2.2 6.5 12.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim17 PF02466.19 ORX52674.1 - 4.2e-37 126.9 7.3 4.9e-37 126.7 7.3 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Oxysterol_BP PF01237.18 ORX52675.1 - 5e-70 236.2 1.3 6.2e-68 229.3 1.3 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein SPT16 PF08644.11 ORX52677.1 - 3.4e-55 186.4 3.7 5.1e-55 185.8 0.0 3.0 3 0 0 3 3 3 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 ORX52677.1 - 2.2e-42 144.6 0.0 5.2e-42 143.4 0.0 1.7 1 0 0 1 1 1 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 ORX52677.1 - 2.5e-28 99.2 0.0 4.5e-28 98.4 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 ORX52677.1 - 1.5e-15 57.3 0.3 4.6e-15 55.8 0.0 2.0 2 0 0 2 2 2 1 Histone chaperone Rttp106-like DUF3956 PF13104.6 ORX52677.1 - 0.084 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3956) HLH PF00010.26 ORX52677.1 - 0.22 11.5 1.4 0.64 10.0 1.4 1.7 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain MFS_1 PF07690.16 ORX52678.1 - 7e-32 110.7 19.8 7e-32 110.7 19.8 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF4191 PF13829.6 ORX52678.1 - 3.6 6.9 6.2 6.7 6.0 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) Wzy_C PF04932.15 ORX52678.1 - 5.3 6.7 13.9 0.45 10.1 0.1 3.1 2 1 0 3 3 3 0 O-Antigen ligase DUF2070 PF09843.9 ORX52678.1 - 7.6 4.7 5.8 4.3 5.5 3.9 1.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) SH3_1 PF00018.28 ORX52679.1 - 1.7e-13 49.9 0.1 2.5e-13 49.4 0.1 1.2 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX52679.1 - 1.7e-12 46.8 0.0 2.3e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX52679.1 - 3.9e-10 39.4 0.0 5.4e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain RasGEF PF00617.19 ORX52680.1 - 2.9e-59 200.2 0.2 7.1e-59 199.0 0.2 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX52680.1 - 8.1e-28 96.7 0.2 4.2e-27 94.4 0.2 2.3 1 0 0 1 1 1 1 RasGEF N-terminal motif WW PF00397.26 ORX52680.1 - 1.7e-12 47.2 2.8 1.3e-07 31.6 0.8 2.7 2 0 0 2 2 2 2 WW domain AAA_16 PF13191.6 ORX52680.1 - 0.058 13.8 2.1 0.14 12.6 1.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain YchF-GTPase_C PF06071.13 ORX52681.1 - 1.5e-40 137.3 0.1 4.7e-40 135.7 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ORX52681.1 - 1.8e-23 82.8 0.0 4e-23 81.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX52681.1 - 6e-08 32.4 0.0 1.2e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B MeaB PF03308.16 ORX52681.1 - 0.015 14.3 0.0 0.032 13.2 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ORX52681.1 - 0.016 15.2 0.0 1.5 8.8 0.1 2.6 1 1 1 2 2 2 0 Dynamin family TGS PF02824.21 ORX52681.1 - 0.08 13.0 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 TGS domain PUF PF00806.19 ORX52682.1 - 2.4e-17 61.5 1.3 0.00063 19.3 0.1 6.9 7 0 0 7 7 7 4 Pumilio-family RNA binding repeat RRM_1 PF00076.22 ORX52682.1 - 1.4e-16 60.0 0.0 2.8e-12 46.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF515 PF04415.12 ORX52682.1 - 0.87 7.9 3.8 1.3 7.3 3.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Herpes_pp85 PF04637.12 ORX52682.1 - 4.9 5.5 5.5 9.3 4.5 5.5 1.4 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Beta-Casp PF10996.8 ORX52683.1 - 3.8e-24 85.1 0.0 1.6e-23 83.1 0.0 2.0 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ORX52683.1 - 1.2e-17 64.0 0.0 2.4e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 ORX52683.1 - 9.1e-16 57.6 0.0 1.9e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 ORX52683.1 - 4.8e-12 46.3 0.1 1.3e-11 44.9 0.1 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX52683.1 - 6e-11 42.2 0.1 7.6e-07 28.8 0.1 2.6 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX52683.1 - 0.00047 20.1 0.0 0.0026 17.7 0.0 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain WDCP PF15390.6 ORX52683.1 - 0.02 13.3 0.1 0.031 12.7 0.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family GDP_Man_Dehyd PF16363.5 ORX52684.1 - 1.7e-157 524.0 0.0 2e-157 523.8 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX52684.1 - 2.8e-72 243.1 0.0 3.5e-72 242.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 ORX52684.1 - 2.3e-06 26.9 0.0 3.1e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NmrA PF05368.13 ORX52684.1 - 0.00063 19.4 0.0 0.00097 18.8 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ORX52684.1 - 0.047 13.1 0.0 0.075 12.5 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ORX52684.1 - 0.048 12.8 0.0 0.074 12.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein YjeF_N PF03853.15 ORX52684.1 - 0.094 12.6 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus GAS2 PF02187.17 ORX52685.1 - 2.5e-13 49.9 0.0 1.2e-12 47.7 0.0 2.2 2 0 0 2 2 2 1 Growth-Arrest-Specific Protein 2 Domain CH PF00307.31 ORX52685.1 - 2.2e-05 24.6 0.6 0.00023 21.3 0.0 3.0 3 0 0 3 3 3 1 Calponin homology (CH) domain Ribosomal_S17_N PF16205.5 ORX52686.1 - 1.9e-28 98.6 1.4 3.9e-28 97.6 1.4 1.6 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ORX52686.1 - 3e-25 88.1 0.4 3e-25 88.1 0.4 1.9 2 0 0 2 2 2 1 Ribosomal protein S17 CAF1 PF04857.20 ORX52687.1 - 1.1e-76 258.1 0.1 1.1e-76 258.1 0.1 2.0 2 0 0 2 2 2 1 CAF1 family ribonuclease CENP-B_dimeris PF09026.10 ORX52687.1 - 0.032 14.6 4.4 0.071 13.5 4.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4637 PF15470.6 ORX52687.1 - 6.9 6.4 6.7 14 5.3 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HSCB_C PF07743.13 ORX52688.1 - 8.4e-19 67.9 3.9 9.4e-19 67.7 3.9 1.0 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain cwf21 PF08312.12 ORX52688.1 - 0.17 12.1 2.6 0.39 10.9 2.6 1.8 1 1 0 1 1 1 0 cwf21 domain Dynactin_p62 PF05502.13 ORX52689.1 - 5.5e-90 302.4 14.8 1.5e-47 162.5 12.4 2.2 1 1 1 2 2 2 2 Dynactin p62 family Glucosamine_iso PF01182.20 ORX52689.1 - 0.12 12.2 0.0 0.66 9.8 0.0 2.0 1 1 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase zf-WRNIP1_ubi PF18279.1 ORX52689.1 - 5.8 7.8 11.1 20 6.1 3.2 3.9 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Zn_clus PF00172.18 ORX52691.1 - 4.7e-05 23.4 11.2 8e-05 22.7 11.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_3 PF08447.12 ORX52691.1 - 0.0042 17.3 0.0 0.0074 16.6 0.0 1.3 1 0 0 1 1 1 1 PAS fold DUF4553 PF15090.6 ORX52691.1 - 0.021 13.9 0.2 0.035 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) PAS PF00989.25 ORX52691.1 - 0.086 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 PAS fold Alk_phosphatase PF00245.20 ORX52693.1 - 4.4e-83 279.5 2.7 5.9e-44 150.7 0.0 2.1 1 1 1 2 2 2 2 Alkaline phosphatase Metalloenzyme PF01676.18 ORX52693.1 - 0.00052 19.5 0.1 0.0011 18.4 0.0 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily DUF1390 PF07150.11 ORX52693.1 - 0.086 12.5 0.1 0.16 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1390) PH PF00169.29 ORX52694.1 - 5.6e-15 55.8 0.1 2.5e-14 53.7 0.1 1.9 1 1 1 2 2 2 1 PH domain PH_11 PF15413.6 ORX52694.1 - 0.00071 20.0 0.4 0.0019 18.6 0.2 1.7 1 1 1 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ORX52694.1 - 0.13 12.6 0.1 0.33 11.3 0.0 1.6 2 0 0 2 2 2 0 Pleckstrin homology domain Arrestin_N PF00339.29 ORX52695.1 - 2.6e-05 24.3 0.0 4.9e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Proteasome PF00227.26 ORX52696.1 - 8.4e-56 188.5 0.1 1.2e-55 188.0 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX52696.1 - 2.1e-15 56.1 0.1 3.7e-15 55.3 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Homeodomain PF00046.29 ORX52696.1 - 0.12 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Homeodomain zf-MIZ PF02891.20 ORX52697.1 - 9.4e-18 63.7 5.2 2.9e-17 62.1 5.2 1.9 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 ORX52697.1 - 2e-05 24.3 1.6 6.1e-05 22.8 1.6 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ORX52697.1 - 2.9 7.8 6.1 6.5 6.7 6.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) ApoO PF09769.9 ORX52697.1 - 8.8 6.3 7.8 24 4.9 7.8 1.6 1 0 0 1 1 1 0 Apolipoprotein O DUF202 PF02656.15 ORX52698.1 - 1.5e-14 54.2 0.4 2.1e-12 47.3 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SdpI PF13630.6 ORX52698.1 - 0.011 15.8 3.5 0.088 13.0 2.7 2.1 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF2976 PF11190.8 ORX52698.1 - 0.055 13.3 0.0 0.096 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) ATP-synt_8 PF00895.20 ORX52698.1 - 0.11 13.0 4.2 0.87 10.1 0.8 2.7 3 0 0 3 3 3 0 ATP synthase protein 8 Saf_2TM PF18303.1 ORX52698.1 - 0.16 11.6 1.7 0.59 9.7 1.4 1.8 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF4149 PF13664.6 ORX52698.1 - 0.16 12.3 2.8 0.34 11.2 2.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) EMP70 PF02990.16 ORX52698.1 - 0.23 10.1 5.0 0.27 9.9 5.0 1.1 1 0 0 1 1 1 0 Endomembrane protein 70 T2SSF PF00482.23 ORX52698.1 - 0.46 10.4 1.9 2.5 8.1 1.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F DUF373 PF04123.13 ORX52698.1 - 0.48 9.8 4.0 0.65 9.4 4.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Jagunal PF07086.12 ORX52698.1 - 0.58 10.2 5.2 0.44 10.6 3.1 1.7 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis DHHC PF01529.20 ORX52698.1 - 0.59 10.2 9.9 2 8.5 4.3 2.1 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF3611 PF12263.8 ORX52698.1 - 3.1 7.7 7.2 15 5.5 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3611) DUF2370 PF10176.9 ORX52698.1 - 7.7 6.1 5.9 22 4.6 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) Exonuc_VII_L PF02601.15 ORX52699.1 - 0.83 9.2 12.9 0.8 9.2 7.2 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit FtsL PF04999.13 ORX52699.1 - 1.4 9.0 10.3 3.6 7.7 10.3 1.6 1 0 0 1 1 1 0 Cell division protein FtsL AAA_23 PF13476.6 ORX52699.1 - 4.7 7.7 12.5 0.2 12.2 6.3 1.8 2 0 0 2 2 2 0 AAA domain PhoQ_Sensor PF08918.10 ORX52699.1 - 7.2 6.4 10.4 1.4 8.7 5.2 2.2 2 0 0 2 2 2 0 PhoQ Sensor Pkinase PF00069.25 ORX52700.1 - 8.3e-25 87.6 0.0 9.7e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX52700.1 - 2.5e-10 40.1 0.0 3.2e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX52700.1 - 5.6e-09 35.3 0.0 7.4e-09 34.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX52700.1 - 0.1 12.5 0.0 14 5.5 0.0 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family DAO PF01266.24 ORX52701.1 - 2.5e-46 158.9 0.2 2.9e-46 158.7 0.2 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX52701.1 - 1.6e-07 30.8 0.1 3.2e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 ORX52701.1 - 1e-05 25.7 0.2 2.5e-05 24.4 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX52701.1 - 0.00066 19.0 0.0 0.0016 17.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX52701.1 - 0.0015 17.7 0.6 0.0023 17.1 0.5 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ORX52701.1 - 0.003 16.8 0.3 0.85 8.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX52701.1 - 0.0046 16.1 0.1 0.0071 15.4 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox PF00070.27 ORX52701.1 - 0.0071 16.9 0.2 0.043 14.4 0.1 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 ORX52701.1 - 0.012 14.2 0.1 0.017 13.7 0.1 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) GMC_oxred_N PF00732.19 ORX52701.1 - 0.078 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 GMC oxidoreductase Trp_halogenase PF04820.14 ORX52701.1 - 0.18 10.6 0.7 0.27 10.0 0.7 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Podoplanin PF05808.11 ORX52702.1 - 0.0093 16.1 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 Podoplanin EVI2A PF05399.11 ORX52702.1 - 0.018 14.6 1.8 0.031 13.9 1.8 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Rick_17kDa_Anti PF05433.15 ORX52702.1 - 0.027 14.3 5.4 0.045 13.6 5.4 1.2 1 0 0 1 1 1 0 Glycine zipper 2TM domain Ndc1_Nup PF09531.10 ORX52702.1 - 0.61 8.7 7.7 0.81 8.3 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Kelch_5 PF13854.6 ORX52703.1 - 2.5e-14 52.9 8.2 2e-05 24.5 0.1 5.8 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 ORX52703.1 - 2e-12 46.9 3.8 0.0027 17.9 0.0 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ORX52703.1 - 1e-09 37.8 1.8 0.00014 21.4 0.1 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ORX52703.1 - 4.8e-08 32.7 0.5 0.43 10.7 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ORX52703.1 - 6e-08 32.6 9.9 0.0051 16.8 0.3 5.6 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX52703.1 - 0.0037 17.5 14.2 0.32 11.3 1.7 5.0 5 1 0 5 5 5 2 Galactose oxidase, central domain SKG6 PF08693.10 ORX52703.1 - 0.013 14.9 3.9 0.028 13.8 3.9 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain UQ_con PF00179.26 ORX52704.1 - 1.9e-15 56.7 0.0 2e-15 56.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX52704.1 - 0.025 14.8 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 RWD domain EF-hand_7 PF13499.6 ORX52705.1 - 1.1e-11 45.0 1.5 1.3e-11 44.7 1.5 1.1 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX52705.1 - 2.1e-10 39.7 1.0 2.1e-06 27.2 0.2 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ORX52705.1 - 6.4e-10 37.9 0.8 0.00023 20.5 0.1 2.8 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 ORX52705.1 - 4e-09 35.5 2.1 0.00023 20.5 0.1 2.6 2 1 1 3 3 3 2 EF hand EF-hand_8 PF13833.6 ORX52705.1 - 1.9e-06 27.6 2.7 0.00051 19.8 0.6 2.7 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX52705.1 - 0.048 14.0 0.1 1.6 9.1 0.1 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region La PF05383.17 ORX52706.1 - 2.7e-20 72.2 0.3 5.7e-20 71.1 0.3 1.6 1 0 0 1 1 1 1 La domain DUF1310 PF07006.11 ORX52706.1 - 0.092 12.7 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1310) Prenyltrans PF00432.21 ORX52707.1 - 6.3e-29 99.4 9.4 1.2e-09 37.8 0.0 5.9 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat Aldedh PF00171.22 ORX52708.1 - 2.3e-16 59.4 4.7 5e-12 45.1 2.1 2.4 2 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF1542 PF07564.11 ORX52708.1 - 0.14 12.3 3.0 0.52 10.4 3.0 2.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) HTH_57 PF18679.1 ORX52708.1 - 0.16 12.3 0.9 1.8 8.9 0.0 2.9 3 1 1 4 4 4 0 ThcOx helix turn helix domain Mito_carr PF00153.27 ORX52709.1 - 1.1e-67 224.0 4.6 6.3e-23 80.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 ORX52709.1 - 1.5e-19 70.2 5.3 6.9e-10 39.2 0.6 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX52709.1 - 1.7e-14 52.4 6.0 0.0055 16.5 0.2 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ORX52709.1 - 4.4e-10 38.4 12.9 0.0065 15.9 0.5 5.1 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 ORX52709.1 - 1.3e-08 34.5 9.3 0.0081 16.0 1.0 4.4 3 1 1 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX52709.1 - 6.8e-06 26.4 1.0 0.0011 19.3 0.1 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ORX52709.1 - 7e-06 25.3 12.0 0.22 11.1 0.4 5.0 5 0 0 5 5 5 2 EF hand EF-hand_4 PF12763.7 ORX52709.1 - 0.0033 17.3 1.7 1.3 9.0 0.2 2.8 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 ORX52709.1 - 0.0063 16.4 3.3 0.21 11.5 0.1 3.8 4 0 0 4 4 4 1 EF hand Vps4_C PF09336.10 ORX52709.1 - 0.19 11.8 0.0 0.74 9.9 0.0 2.0 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain F-box-like PF12937.7 ORX52710.1 - 2.4e-08 33.7 2.1 3.9e-08 33.1 0.5 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX52710.1 - 3.8e-06 26.6 0.1 3.8e-06 26.6 0.1 2.6 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ORX52711.1 - 0.0036 17.2 0.5 0.022 14.7 0.2 2.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX52711.1 - 0.02 14.8 0.1 0.13 12.2 0.0 2.5 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ORX52714.1 - 0.0024 17.7 0.5 0.0064 16.4 0.5 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX52714.1 - 0.025 14.5 0.0 0.1 12.5 0.0 2.1 1 0 0 1 1 1 0 F-box domain Amelotin PF15757.5 ORX52714.1 - 0.16 11.5 0.1 0.38 10.3 0.1 1.5 1 0 0 1 1 1 0 Amelotin LRR_4 PF12799.7 ORX52715.1 - 5.6e-05 23.4 6.3 17 6.0 0.5 6.8 6 1 0 6 6 6 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ORX52715.1 - 0.00014 21.7 2.7 0.011 15.6 0.1 3.6 2 1 1 3 3 3 1 F-box-like F-box PF00646.33 ORX52715.1 - 0.015 15.2 0.1 0.15 11.9 0.0 3.0 1 1 0 1 1 1 0 F-box domain F-box-like PF12937.7 ORX52716.1 - 5.9e-05 22.9 1.5 0.00014 21.6 1.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX52716.1 - 0.054 13.4 0.6 0.19 11.7 0.3 2.1 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ORX52717.1 - 0.017 15.0 0.1 0.044 13.7 0.1 1.8 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 ORX52717.1 - 0.34 10.8 0.1 0.34 10.8 0.1 2.8 3 0 0 3 3 3 0 F-box domain F-box-like PF12937.7 ORX52718.1 - 1e-12 47.7 2.4 3.6e-06 26.8 0.1 2.8 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 ORX52718.1 - 1.1e-11 44.3 4.2 9e-07 28.6 0.0 3.5 3 0 0 3 3 3 2 F-box domain LRR_2 PF07723.13 ORX52718.1 - 0.011 16.4 5.3 34 5.3 0.0 6.0 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 ORX52718.1 - 0.083 13.3 34.9 0.17 12.3 0.4 9.9 10 2 1 12 12 12 0 Leucine Rich repeats (2 copies) DUF5305 PF17231.2 ORX52719.1 - 0.066 12.6 0.3 0.11 11.9 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) F-box-like PF12937.7 ORX52720.1 - 0.00025 20.9 1.5 0.00078 19.3 1.5 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX52720.1 - 0.00086 19.1 1.8 0.0018 18.1 1.0 2.0 2 0 0 2 2 2 1 F-box domain PRIMA1 PF16101.5 ORX52720.1 - 0.15 12.1 0.7 0.34 10.9 0.7 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 2OG-FeII_Oxy_2 PF13532.6 ORX52721.1 - 1.1e-22 81.2 0.0 1.6e-22 80.7 0.0 1.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-met PF12874.7 ORX52722.1 - 5.8e-07 29.7 0.6 1e-06 28.9 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX52722.1 - 2.3e-05 24.5 0.5 4.8e-05 23.5 0.5 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ORX52722.1 - 0.009 16.3 0.2 0.02 15.2 0.2 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) YL1 PF05764.13 ORX52722.1 - 0.099 12.7 30.1 0.13 12.3 30.1 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF1168 PF06658.12 ORX52722.1 - 8.4 6.2 35.1 11 5.8 23.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1168) Cwf_Cwc_15 PF04889.12 ORX52725.1 - 0.44 10.3 11.2 0.47 10.1 11.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ORX52725.1 - 0.49 10.8 9.9 0.56 10.6 9.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CobT PF06213.12 ORX52725.1 - 0.96 8.8 9.0 1.2 8.5 9.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 ORX52725.1 - 1.5 8.5 6.6 1.7 8.3 6.6 1.1 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ORX52725.1 - 1.7 7.9 10.4 2.2 7.6 10.4 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ORX52725.1 - 2.5 6.1 10.4 2.4 6.2 10.4 1.0 1 0 0 1 1 1 0 DNA polymerase phi Aldose_epim PF01263.20 ORX52727.1 - 6.9e-85 285.0 0.6 7.8e-85 284.8 0.6 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase PAP2 PF01569.21 ORX52730.1 - 2e-30 105.3 3.1 2e-30 105.3 3.1 2.0 2 1 0 2 2 2 1 PAP2 superfamily DUF5367 PF17329.2 ORX52730.1 - 0.015 15.4 0.6 0.015 15.4 0.6 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5367) Virul_fac_BrkB PF03631.15 ORX52730.1 - 0.044 13.4 9.9 0.027 14.1 2.6 2.2 2 0 0 2 2 2 0 Virulence factor BrkB EcsB PF05975.12 ORX52730.1 - 0.052 12.4 4.2 0.023 13.5 2.1 1.4 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB DUF2207 PF09972.9 ORX52730.1 - 0.13 11.0 3.2 0.12 11.1 0.2 1.9 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3093 PF11292.8 ORX52730.1 - 0.2 11.9 0.1 0.2 11.9 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3093) PAP2_C PF14360.6 ORX52730.1 - 1.9 9.1 6.3 0.72 10.4 1.9 2.4 3 0 0 3 3 3 0 PAP2 superfamily C-terminal PAP2_3 PF14378.6 ORX52730.1 - 5.7 6.6 15.3 0.87 9.2 1.5 3.0 2 1 1 3 3 3 0 PAP2 superfamily ADK PF00406.22 ORX52731.1 - 6.8e-50 169.1 0.0 8.8e-50 168.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX52731.1 - 3.4e-24 85.8 0.0 6.3e-24 84.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ORX52731.1 - 2.9e-13 49.6 0.0 5.4e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ORX52731.1 - 3.8e-06 27.5 0.0 6.3e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX52731.1 - 0.0017 18.6 0.1 0.0064 16.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ORX52731.1 - 0.06 12.6 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Mg_chelatase PF01078.21 ORX52731.1 - 0.15 11.4 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ORX52731.1 - 0.17 12.2 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DnaJ PF00226.31 ORX52732.1 - 2e-27 95.1 1.2 5.7e-27 93.6 1.2 1.8 2 0 0 2 2 2 1 DnaJ domain Tmemb_185A PF10269.9 ORX52732.1 - 4.4e-12 46.2 38.2 9.7e-05 22.2 5.0 3.5 1 1 1 3 3 3 3 Transmembrane Fragile-X-F protein PBP1_TM PF14812.6 ORX52732.1 - 0.0024 18.2 0.3 0.012 16.0 0.3 2.2 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Shisa PF13908.6 ORX52732.1 - 0.16 12.2 1.7 20 5.4 1.8 2.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF1676 PF07898.13 ORX52732.1 - 0.43 10.6 1.2 1.6 8.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Orf78 PF06024.12 ORX52732.1 - 0.54 10.6 10.4 1.8 8.9 0.0 4.3 4 1 0 4 4 4 0 Orf78 (ac78) Peptidase_M18 PF02127.15 ORX52733.1 - 1.6e-167 557.7 0.0 1.8e-167 557.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ORX52733.1 - 6.5e-08 31.9 0.2 9.4e-07 28.1 0.2 2.0 1 1 1 2 2 2 2 M42 glutamyl aminopeptidase GTP_cyclohydroI PF01227.22 ORX52734.1 - 8.4e-77 256.6 0.4 8.4e-77 256.6 0.4 1.3 1 1 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ORX52734.1 - 0.0014 18.7 0.1 0.0033 17.6 0.0 1.6 2 0 0 2 2 2 1 QueF-like protein DUF3475 PF11961.8 ORX52735.1 - 1.6 8.8 3.1 1.4 9.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3475) Iso_dh PF00180.20 ORX52736.1 - 5.8e-80 269.1 0.1 7.4e-80 268.7 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DNAPolymera_Pol PF11590.8 ORX52736.1 - 0.03 14.2 0.2 0.074 13.0 0.2 1.7 1 0 0 1 1 1 0 DNA polymerase catalytic subunit Pol HAGH_C PF16123.5 ORX52737.1 - 9.8e-16 58.1 0.0 1.6e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B_2 PF12706.7 ORX52737.1 - 0.00074 19.1 0.4 0.0028 17.2 0.4 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX52737.1 - 0.00085 19.4 6.7 0.28 11.2 6.7 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Arginase PF00491.21 ORX52738.1 - 6.3e-72 242.4 0.0 7.4e-72 242.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family Aldedh PF00171.22 ORX52739.1 - 1.2e-83 281.2 0.0 2.9e-80 270.0 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family DUF3396 PF11876.8 ORX52740.1 - 0.05 13.1 0.1 0.097 12.1 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3396) FAM104 PF15434.6 ORX52740.1 - 0.051 14.1 0.4 8.8 6.9 0.0 2.1 1 1 1 2 2 2 0 Family 104 NAD_Gly3P_dh_N PF01210.23 ORX52741.1 - 4.9e-54 182.6 0.4 8.6e-54 181.8 0.4 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ORX52741.1 - 1.9e-49 167.6 0.1 3.9e-49 166.6 0.1 1.6 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 ORX52741.1 - 0.00022 21.7 0.8 0.0064 17.0 0.8 2.3 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Ank_2 PF12796.7 ORX52742.1 - 5.5e-95 312.1 40.6 3e-17 63.0 0.1 18.8 10 5 11 21 21 21 16 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX52742.1 - 1.8e-78 257.9 32.2 3.8e-10 40.1 0.6 21.6 20 3 2 22 22 22 13 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX52742.1 - 1.1e-54 181.8 43.2 5.9e-09 36.0 0.2 21.7 18 4 6 24 24 24 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX52742.1 - 8.2e-54 173.3 41.7 8e-05 22.8 0.0 24.4 29 0 0 29 29 29 12 Ankyrin repeat Ank PF00023.30 ORX52742.1 - 2.7e-48 160.4 51.4 8.8e-05 22.8 0.1 22.9 22 2 0 22 22 22 13 Ankyrin repeat PARP PF00644.20 ORX52742.1 - 1.7e-44 151.8 0.2 4.5e-44 150.4 0.0 1.9 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 ORX52742.1 - 3.5e-14 52.6 0.0 9.3e-14 51.3 0.0 1.8 1 0 0 1 1 1 1 WGR domain PARP_reg PF02877.14 ORX52742.1 - 8.2e-09 35.7 0.0 1.9e-08 34.5 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain zf-CRD PF17979.1 ORX52742.1 - 0.00031 20.9 0.2 0.00083 19.5 0.2 1.7 1 0 0 1 1 1 1 Cysteine rich domain with multizinc binding regions DUF3447 PF11929.8 ORX52742.1 - 0.059 13.3 0.1 11 6.1 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3447) Yos1 PF08571.10 ORX52743.1 - 3.6e-35 120.1 0.9 4e-35 119.9 0.9 1.0 1 0 0 1 1 1 1 Yos1-like GATA PF00320.27 ORX52744.1 - 1.1e-16 60.1 3.4 1.4e-16 59.7 3.4 1.2 1 0 0 1 1 1 1 GATA zinc finger zf-RRN7 PF11781.8 ORX52744.1 - 0.0018 17.9 2.7 0.08 12.6 0.0 2.2 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 TF_Zn_Ribbon PF08271.12 ORX52744.1 - 0.0038 16.7 0.6 0.0052 16.3 0.6 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding Apocytochr_F_N PF16639.5 ORX52744.1 - 0.016 15.5 0.7 0.1 12.8 0.0 1.9 1 1 1 2 2 2 0 Apocytochrome F, N-terminal Auto_anti-p27 PF06677.12 ORX52744.1 - 0.028 14.6 0.6 0.038 14.1 0.6 1.2 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Zn-ribbon_8 PF09723.10 ORX52744.1 - 0.042 14.0 0.1 0.053 13.6 0.1 1.3 1 0 0 1 1 1 0 Zinc ribbon domain zf-Sec23_Sec24 PF04810.15 ORX52744.1 - 0.051 13.6 1.6 0.066 13.3 1.6 1.2 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger OsmC PF02566.19 ORX52745.1 - 6.1 7.4 6.9 1.2 9.7 1.3 2.8 2 0 0 2 2 2 0 OsmC-like protein Lactamase_B_6 PF16661.5 ORX52746.1 - 5.5e-10 39.0 0.0 1.3e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ORX52746.1 - 0.0024 17.2 0.0 0.0048 16.1 0.0 1.5 1 0 0 1 1 1 1 Putative beta-lactamase-like family CN_hydrolase PF00795.22 ORX52747.1 - 5.5e-28 98.0 0.0 7e-28 97.7 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Peptidase_S10 PF00450.22 ORX52748.1 - 4.2e-111 372.3 5.6 5.2e-111 372.0 5.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Rep_fac-A_C PF08646.10 ORX52749.1 - 7.7e-09 35.4 1.8 1e-08 35.0 1.8 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain CDC24_OB3 PF17244.2 ORX52749.1 - 0.005 16.6 0.3 0.0063 16.3 0.3 1.2 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 Ribosomal_S19e PF01090.19 ORX52750.1 - 3.9e-60 201.5 0.2 4.4e-60 201.3 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Peptidase_S10 PF00450.22 ORX52752.1 - 2.2e-105 353.5 0.6 2.8e-105 353.2 0.6 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase RhoGEF PF00621.20 ORX52753.1 - 1.1e-30 107.3 0.1 1.1e-30 107.3 0.1 1.9 3 0 0 3 3 3 1 RhoGEF domain PH PF00169.29 ORX52753.1 - 0.00016 22.2 0.1 0.00041 20.8 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ORX52753.1 - 0.12 12.2 0.8 0.36 10.6 0.3 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain zf-CCCH_2 PF14608.6 ORX52754.1 - 1.4e-05 25.3 2.7 2.9e-05 24.4 2.7 1.5 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ORX52754.1 - 0.0031 17.3 1.5 0.0049 16.6 1.5 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX52754.1 - 0.016 15.2 0.8 0.016 15.2 0.8 1.7 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 ORX52754.1 - 0.026 14.4 2.8 0.062 13.2 2.8 1.6 1 1 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) PDCD7 PF16021.5 ORX52755.1 - 1.6e-06 27.5 4.8 1.6e-06 27.5 4.8 2.9 3 0 0 3 3 3 2 Programmed cell death protein 7 Peptidase_S49_N PF08496.10 ORX52755.1 - 0.25 11.4 5.6 0.36 10.9 2.4 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Snapin_Pallidin PF14712.6 ORX52755.1 - 0.55 10.7 8.8 0.21 12.0 6.0 1.7 2 0 0 2 2 2 0 Snapin/Pallidin MRP-S33 PF08293.11 ORX52756.1 - 1.5e-30 105.3 0.2 1.8e-30 105.0 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 ProRS-C_1 PF09180.11 ORX52757.1 - 4.4e-24 84.5 0.1 9.8e-24 83.4 0.1 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 ORX52757.1 - 8.1e-19 67.6 0.0 4e-18 65.4 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ORX52757.1 - 8.3e-19 68.2 0.0 2e-18 67.0 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 ORX52757.1 - 9.2e-15 54.8 0.2 2e-14 53.7 0.2 1.6 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Ribosomal_60s PF00428.19 ORX52757.1 - 0.0081 16.7 8.4 0.0081 16.7 8.4 2.4 3 0 0 3 3 3 1 60s Acidic ribosomal protein DUF3138 PF11336.8 ORX52757.1 - 3.9 6.0 5.5 6 5.4 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) GATA PF00320.27 ORX52758.1 - 2.2e-13 49.5 4.5 4.9e-13 48.4 4.5 1.6 1 0 0 1 1 1 1 GATA zinc finger zf-NADH-PPase PF09297.11 ORX52758.1 - 0.37 10.5 3.5 0.83 9.4 0.2 2.4 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain AAR2 PF05282.11 ORX52759.1 - 2.1e-91 307.0 2.2 2.6e-90 303.4 2.2 1.9 1 1 0 1 1 1 1 AAR2 protein DUF4604 PF15377.6 ORX52759.1 - 0.12 12.8 0.3 0.19 12.2 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) VHS PF00790.19 ORX52761.1 - 5.6e-37 126.7 4.2 5.8e-37 126.7 0.1 2.5 3 0 0 3 3 3 1 VHS domain FYVE PF01363.21 ORX52761.1 - 1.1e-16 60.6 9.9 2.3e-16 59.7 9.9 1.5 1 0 0 1 1 1 1 FYVE zinc finger GAT PF03127.14 ORX52761.1 - 1.6e-05 25.1 0.7 8.1e-05 22.9 0.1 2.5 3 0 0 3 3 3 1 GAT domain UIM PF02809.20 ORX52761.1 - 0.0021 17.8 5.2 0.28 11.2 0.6 3.1 2 0 0 2 2 2 2 Ubiquitin interaction motif Hrs_helical PF12210.8 ORX52761.1 - 0.035 14.6 0.3 0.079 13.5 0.3 1.6 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate FYVE_2 PF02318.16 ORX52761.1 - 0.1 12.8 6.3 0.23 11.7 6.3 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger OB_NTP_bind PF07717.16 ORX52763.1 - 1.5e-20 73.3 0.2 3.6e-20 72.1 0.2 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ORX52763.1 - 1.8e-20 73.2 0.6 3.9e-20 72.1 0.2 1.8 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ORX52763.1 - 1.4e-09 38.2 0.0 3e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain bZIP_2 PF07716.15 ORX52764.1 - 5.7e-06 26.3 7.3 5.7e-06 26.3 7.3 2.9 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX52764.1 - 0.0018 18.4 13.8 0.0046 17.0 2.8 3.0 2 1 1 3 3 3 3 bZIP transcription factor ATAD4 PF15321.6 ORX52764.1 - 0.0041 18.4 1.8 0.0041 18.4 1.8 1.7 2 0 0 2 2 2 1 ATPase family AAA domain containing 4 UreF PF01730.16 ORX52765.1 - 6.9e-24 84.9 0.2 1.1e-23 84.3 0.1 1.4 2 0 0 2 2 2 1 UreF Ytp1 PF10355.9 ORX52767.1 - 6.9e-50 169.8 22.2 8.1e-48 163.0 22.2 2.4 1 1 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 ORX52767.1 - 1.9e-25 88.7 6.1 1.9e-25 88.7 6.1 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 ORX52767.1 - 0.00068 19.8 13.8 0.00068 19.8 13.8 3.5 3 1 0 3 3 3 2 Eukaryotic cytochrome b561 Atypical_Card PF18461.1 ORX52768.1 - 0.015 15.5 0.2 0.13 12.5 0.0 2.4 3 0 0 3 3 3 0 Atypical caspase recruitment domain Chorein_N PF12624.7 ORX52770.1 - 4.1e-19 68.8 0.0 6.3e-18 65.0 0.0 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG2_CAD PF13329.6 ORX52770.1 - 1.3e-11 44.5 1.1 3.5e-11 43.0 1.1 1.7 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif VPS13_C PF16909.5 ORX52770.1 - 3.3e-06 27.0 0.1 7.5e-06 25.8 0.1 1.6 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal DUF3020 PF11223.8 ORX52771.1 - 2.1e-19 69.7 5.0 4.5e-19 68.7 5.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3020) zf-UBP PF02148.19 ORX52771.1 - 0.0011 19.2 8.1 0.0027 18.0 8.1 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein DUSP PF06337.12 ORX52771.1 - 0.014 16.0 0.0 0.039 14.6 0.0 1.8 1 0 0 1 1 1 0 DUSP domain F-box PF00646.33 ORX52771.1 - 0.018 14.9 2.3 0.026 14.4 0.6 2.2 2 0 0 2 2 2 0 F-box domain CEBP_ZZ PF16366.5 ORX52771.1 - 1.2 9.5 11.7 0.27 11.5 7.3 2.1 1 1 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain Sulfate_transp PF00916.20 ORX52772.1 - 8.6e-101 337.4 23.5 1.1e-100 337.1 23.5 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX52772.1 - 1.3e-05 24.8 0.0 2.5e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX52772.1 - 5.4e-05 23.6 5.6 5.4e-05 23.6 5.6 3.1 2 1 0 2 2 2 1 Molybdate transporter of MFS superfamily Proton_antipo_N PF00662.20 ORX52772.1 - 0.96 9.6 4.6 0.45 10.6 0.1 2.6 2 0 0 2 2 2 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 14-3-3 PF00244.20 ORX52773.1 - 4.7e-106 353.3 4.5 5.4e-106 353.1 4.5 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 ORX52773.1 - 0.053 13.5 0.2 0.12 12.4 0.2 1.6 1 0 0 1 1 1 0 Flagellar protein FlaF XhlA PF10779.9 ORX52773.1 - 0.29 11.3 1.4 0.37 11.0 0.2 1.8 2 0 0 2 2 2 0 Haemolysin XhlA Gti1_Pac2 PF09729.9 ORX52774.1 - 1.2e-57 194.9 1.3 8.8e-45 153.0 0.1 2.1 1 1 1 2 2 2 2 Gti1/Pac2 family Formyl_trans_N PF00551.19 ORX52775.1 - 3.1e-29 102.0 0.0 4.8e-29 101.4 0.0 1.3 1 0 0 1 1 1 1 Formyl transferase Formyl_trans_C PF02911.18 ORX52775.1 - 2e-09 37.6 0.0 3.9e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Formyl transferase, C-terminal domain PX PF00787.24 ORX52776.1 - 1.3e-08 34.8 0.4 1.3e-08 34.8 0.4 1.8 2 0 0 2 2 2 1 PX domain PB1 PF00564.24 ORX52776.1 - 0.00064 19.6 0.0 0.046 13.6 0.0 2.4 2 0 0 2 2 2 2 PB1 domain Acyl-CoA_dh_1 PF00441.24 ORX52777.1 - 0.11 12.6 0.2 0.3 11.3 0.0 1.7 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain Glyoxalase PF00903.25 ORX52778.1 - 1.3e-24 86.9 0.1 1.5e-24 86.7 0.1 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ORX52778.1 - 1e-08 35.4 0.0 2.9e-08 34.0 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ORX52778.1 - 6.8e-05 22.8 0.0 0.14 12.1 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_6 PF18029.1 ORX52778.1 - 0.00026 21.7 0.0 0.0005 20.8 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_3 PF13468.6 ORX52778.1 - 0.016 15.3 0.0 0.27 11.4 0.0 2.2 1 1 0 1 1 1 0 Glyoxalase-like domain CppA_N PF14506.6 ORX52778.1 - 0.041 13.9 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 CppA N-terminal Pyridoxal_deC PF00282.19 ORX52779.1 - 1.7e-76 257.4 0.0 2.2e-76 257.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 ORX52779.1 - 8.5e-06 25.0 0.0 3.6e-05 22.9 0.0 2.0 2 1 0 2 2 2 1 Aminotransferase class-V zf-C2H2 PF00096.26 ORX52780.1 - 0.0015 18.8 12.2 0.021 15.2 0.9 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 ORX52780.1 - 0.03 14.4 12.9 0.27 11.4 1.0 2.9 3 0 0 3 3 3 0 Aberrant zinc-finger zf_Hakai PF18408.1 ORX52780.1 - 0.098 12.4 7.3 1.4 8.7 1.4 2.6 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_4 PF13894.6 ORX52780.1 - 0.14 13.1 19.9 1 10.4 0.2 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger TB2_DP1_HVA22 PF03134.19 ORX52781.1 - 3.1e-25 87.9 3.7 3.1e-25 87.9 3.7 1.6 2 0 0 2 2 2 1 TB2/DP1, HVA22 family MINDY_DUB PF04424.13 ORX52782.1 - 2.1e-32 111.6 0.0 6.3e-32 110.0 0.0 1.8 1 1 0 1 1 1 1 MINDY deubiquitinase RabGAP-TBC PF00566.18 ORX52783.1 - 7.5e-33 114.0 0.1 1.7e-32 112.9 0.1 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LolB PF03550.14 ORX52783.1 - 0.0017 18.4 0.3 0.0057 16.7 0.0 2.0 2 1 0 2 2 2 1 Outer membrane lipoprotein LolB MAD PF05557.13 ORX52783.1 - 0.0024 16.3 8.2 0.0035 15.8 8.2 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein GAS PF13851.6 ORX52783.1 - 0.0061 15.9 14.5 0.21 10.9 6.5 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding KASH_CCD PF14662.6 ORX52783.1 - 0.0092 15.8 11.2 0.015 15.1 11.2 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Cnn_1N PF07989.11 ORX52783.1 - 0.015 15.4 6.4 0.033 14.4 1.4 3.0 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 YabA PF06156.13 ORX52783.1 - 0.017 15.7 7.4 0.66 10.7 1.6 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF4201 PF13870.6 ORX52783.1 - 0.032 14.0 13.6 0.43 10.3 4.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Lipoprotein_7 PF01540.16 ORX52783.1 - 0.036 13.4 2.6 0.053 12.8 2.6 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein BRE1 PF08647.11 ORX52783.1 - 0.096 12.8 14.0 0.25 11.5 7.0 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Ribosomal_S30AE PF02482.19 ORX52783.1 - 0.13 13.1 1.0 0.27 12.1 1.0 1.5 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein ZapB PF06005.12 ORX52783.1 - 0.13 12.7 11.9 2.8 8.4 1.3 2.4 1 1 1 2 2 2 0 Cell division protein ZapB Fib_alpha PF08702.10 ORX52783.1 - 0.18 12.0 7.7 0.37 11.0 7.0 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 ORX52783.1 - 0.4 11.0 11.3 0.23 11.8 2.7 2.7 2 0 0 2 2 2 0 Uncharacterized conserved protein MbeD_MobD PF04899.12 ORX52783.1 - 0.43 10.7 11.5 0.23 11.6 1.8 3.4 2 1 1 3 3 3 0 MbeD/MobD like CENP-F_leu_zip PF10473.9 ORX52783.1 - 0.48 10.4 10.4 1.1 9.2 10.4 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 ORX52783.1 - 0.51 11.3 11.1 0.18 12.7 6.0 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Tup_N PF08581.10 ORX52783.1 - 0.89 9.9 5.0 1.1 9.7 0.9 2.5 2 0 0 2 2 2 0 Tup N-terminal KIAA1430 PF13879.6 ORX52783.1 - 1 10.2 8.2 0.32 11.8 3.2 2.2 1 1 1 2 2 2 0 KIAA1430 homologue TPR_MLP1_2 PF07926.12 ORX52783.1 - 1.5 8.8 16.7 1.7 8.7 12.2 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GIT_CC PF16559.5 ORX52783.1 - 1.8 8.5 9.5 0.76 9.7 0.7 3.4 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF1664 PF07889.12 ORX52783.1 - 1.8 8.6 8.2 0.52 10.3 2.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ORX52783.1 - 3 8.0 18.9 12 6.0 16.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 ORX52783.1 - 3 8.0 11.7 3.6 7.7 2.1 2.3 1 1 1 2 2 2 0 Tropomyosin like TMF_DNA_bd PF12329.8 ORX52783.1 - 3.5 7.7 8.3 7.1 6.7 0.7 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Laminin_II PF06009.12 ORX52783.1 - 5 7.1 10.2 3.9 7.5 4.3 2.2 1 1 1 2 2 2 0 Laminin Domain II CdvA PF18822.1 ORX52783.1 - 5.1 6.9 7.2 8.5 6.2 1.7 2.7 1 1 2 3 3 3 0 CdvA-like coiled-coil domain ADIP PF11559.8 ORX52783.1 - 5.8 7.0 18.1 5.1 7.2 3.1 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 ORX52783.1 - 6.5 7.3 15.3 1.7e+02 2.7 15.4 2.5 1 1 0 1 1 1 0 Apg6 coiled-coil region FUSC PF04632.12 ORX52783.1 - 6.5 5.2 10.3 9.4 4.6 10.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family SlyX PF04102.12 ORX52783.1 - 6.6 7.4 10.6 27 5.5 0.9 3.0 2 0 0 2 2 2 0 SlyX CLZ PF16526.5 ORX52783.1 - 7 7.1 9.5 3.5 8.1 1.1 2.9 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CHDCT2 PF08074.11 ORX52783.1 - 7.1 6.8 10.2 14 5.8 3.7 2.7 2 1 0 2 2 2 0 CHDCT2 (NUC038) domain Jnk-SapK_ap_N PF09744.9 ORX52783.1 - 8.7 6.5 15.2 8.8 6.5 2.7 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 ORX52783.1 - 9.9 6.2 11.5 9.7 6.3 10.2 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Serpentine_r_xa PF03383.15 ORX52784.1 - 0.14 12.2 0.5 0.19 11.7 0.5 1.4 1 0 0 1 1 1 0 Caenorhabditis serpentine receptor-like protein, class xa zf-C2H2 PF00096.26 ORX52785.1 - 7.5e-08 32.4 23.8 0.00041 20.6 0.2 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX52785.1 - 1.3e-06 28.6 19.8 0.00034 20.9 0.9 4.7 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX52785.1 - 4.9e-05 23.8 19.8 0.052 14.4 0.1 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX52785.1 - 0.003 18.1 8.8 0.0033 18.0 0.7 3.4 2 2 2 4 4 4 1 FOXP coiled-coil domain Zap1_zf2 PF18217.1 ORX52785.1 - 0.039 14.0 2.4 0.074 13.1 0.1 2.4 2 0 0 2 2 2 0 Zap1 zinc finger 2 zf_ZIC PF18366.1 ORX52785.1 - 0.2 11.8 8.3 0.11 12.7 0.9 3.5 3 1 0 3 3 3 0 Zic proteins zinc finger domain zf-Di19 PF05605.12 ORX52785.1 - 0.27 11.5 5.3 4.2 7.7 1.2 2.9 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ORX52785.1 - 0.55 10.3 6.7 0.76 9.9 0.0 3.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX52785.1 - 7.6 7.0 8.2 3.2 8.2 0.0 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 ORX52785.1 - 9.6 7.0 8.1 18 6.1 1.2 2.9 2 1 1 3 3 3 0 TRAF-type zinc finger Aminotran_5 PF00266.19 ORX52786.1 - 1.5e-93 313.7 0.0 2.2e-93 313.2 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ORX52786.1 - 6.6e-06 25.6 0.1 9.8e-06 25.1 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ORX52786.1 - 0.0004 19.8 0.1 0.00075 18.9 0.1 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 ORX52786.1 - 0.047 12.4 0.0 0.074 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain DUF3217 PF11506.8 ORX52786.1 - 0.12 12.3 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) RhoGEF PF00621.20 ORX52787.1 - 5.6e-23 82.1 1.1 9.7e-23 81.3 1.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ORX52787.1 - 0.019 15.5 0.2 0.92 10.0 0.2 2.6 1 1 0 1 1 1 0 PH domain Adaptin_N PF01602.20 ORX52788.1 - 2.6e-32 112.1 2.9 1.3e-31 109.7 1.8 2.1 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 ORX52788.1 - 6.7e-05 23.0 0.1 0.00026 21.1 0.1 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 AP4E_app_platf PF14807.6 ORX52788.1 - 0.0018 18.6 0.0 0.0043 17.4 0.0 1.7 1 0 0 1 1 1 1 Adaptin AP4 complex epsilon appendage platform HEAT_2 PF13646.6 ORX52788.1 - 0.005 17.2 1.9 0.26 11.7 0.1 3.5 4 0 0 4 4 4 1 HEAT repeats DUF1160 PF06648.11 ORX52788.1 - 0.012 15.6 0.4 0.048 13.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1160) ATP-synt_F PF01990.17 ORX52788.1 - 0.057 13.8 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit SRF-TF PF00319.18 ORX52789.1 - 4.2e-22 77.4 0.1 5.8e-22 76.9 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) YhzD PF14120.6 ORX52789.1 - 0.0068 16.5 1.4 0.16 12.1 1.1 2.5 2 1 0 2 2 2 1 YhzD-like protein DUF3931 PF13082.6 ORX52789.1 - 0.11 12.6 0.2 0.38 11.0 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3931) adh_short PF00106.25 ORX52790.1 - 2.9e-14 53.0 0.9 3.1e-14 52.9 0.9 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX52790.1 - 1.3e-11 44.5 0.9 1.4e-11 44.4 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX52790.1 - 0.0081 16.1 0.1 0.009 15.9 0.1 1.0 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ORX52790.1 - 0.056 13.3 0.2 0.056 13.3 0.2 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PilS PF08805.11 ORX52790.1 - 0.083 12.7 0.1 0.089 12.6 0.1 1.0 1 0 0 1 1 1 0 PilS N terminal D123 PF07065.14 ORX52791.1 - 4e-103 344.8 1.6 5.4e-103 344.3 1.6 1.1 1 0 0 1 1 1 1 D123 adh_short_C2 PF13561.6 ORX52791.1 - 2.3e-43 148.4 0.0 3.7e-43 147.8 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX52791.1 - 1e-24 87.1 0.0 1.5e-24 86.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase SPC12 PF06645.13 ORX52792.1 - 5e-27 93.8 0.6 5.8e-27 93.6 0.6 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) ZYG-11_interact PF05884.12 ORX52792.1 - 0.029 13.8 0.1 0.032 13.7 0.1 1.0 1 0 0 1 1 1 0 Interactor of ZYG-11 LapA_dom PF06305.11 ORX52792.1 - 0.035 13.9 0.1 0.14 12.0 0.1 1.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain PfkB PF00294.24 ORX52793.1 - 1.5e-35 123.0 0.4 1.9e-35 122.6 0.4 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase FixH PF05751.11 ORX52793.1 - 0.008 16.2 0.0 0.31 11.0 0.0 2.2 1 1 1 2 2 2 1 FixH TMEM154 PF15102.6 ORX52794.1 - 0.01 15.7 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF2976 PF11190.8 ORX52794.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2976) Arabinose_trans PF04602.12 ORX52794.1 - 0.018 13.9 0.3 0.072 11.9 0.0 1.8 1 1 1 2 2 2 0 Mycobacterial cell wall arabinan synthesis protein TMEM51 PF15345.6 ORX52794.1 - 0.021 14.7 0.0 0.025 14.5 0.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 TMEM223 PF14640.6 ORX52794.1 - 0.022 14.9 0.0 0.024 14.8 0.0 1.2 1 1 0 1 1 1 0 Transmembrane protein 223 SARAF PF06682.12 ORX52794.1 - 0.023 14.4 0.1 0.026 14.2 0.1 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3169 PF11368.8 ORX52794.1 - 0.026 14.0 0.0 0.032 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) DUF4834 PF16118.5 ORX52794.1 - 0.061 14.3 1.8 0.098 13.6 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Peptidase_M56 PF05569.11 ORX52794.1 - 0.089 12.0 0.0 0.1 11.8 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 TIM21 PF08294.11 ORX52794.1 - 0.17 11.8 0.8 0.28 11.0 0.8 1.3 1 0 0 1 1 1 0 TIM21 Plasmodium_Vir PF05795.11 ORX52794.1 - 0.17 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4083 PF13314.6 ORX52794.1 - 0.21 11.6 2.2 0.39 10.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) FeoB_associated PF12669.7 ORX52794.1 - 0.53 10.7 2.7 0.86 10.0 2.7 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein LRR_6 PF13516.6 ORX52795.1 - 3.6e-17 60.9 26.4 0.01 15.8 0.0 10.8 11 0 0 11 11 11 7 Leucine Rich repeat LRR_4 PF12799.7 ORX52795.1 - 8.5e-17 61.0 8.5 0.0046 17.3 0.1 6.5 5 1 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX52795.1 - 8.1e-14 51.1 8.1 0.0002 21.1 0.0 5.5 4 1 1 5 5 5 4 Leucine rich repeat UBX PF00789.20 ORX52795.1 - 1.3e-10 41.3 0.0 3.2e-10 40.1 0.0 1.7 1 0 0 1 1 1 1 UBX domain FA_hydroxylase PF04116.13 ORX52796.1 - 4e-14 53.1 18.2 4e-14 53.1 18.2 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Cyt-b5 PF00173.28 ORX52796.1 - 4.9e-08 33.0 0.0 4.9e-08 33.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain SH3_9 PF14604.6 ORX52797.1 - 5e-05 23.1 0.0 0.0001 22.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX52797.1 - 9.1e-05 22.0 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX52797.1 - 0.00023 20.8 0.0 0.00045 19.9 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Insulin_TMD PF17870.1 ORX52797.1 - 0.074 13.1 0.2 0.15 12.2 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment PDZ_5 PF17817.1 ORX52799.1 - 0.00068 19.9 0.0 0.0021 18.3 0.0 1.8 1 0 0 1 1 1 1 PDZ domain Ank_2 PF12796.7 ORX52800.1 - 4.7e-10 39.9 1.8 0.00022 21.8 0.2 2.9 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX52800.1 - 2.1e-09 37.7 4.4 6.5e-06 26.6 0.3 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX52800.1 - 4.8e-09 35.7 6.9 0.21 12.2 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 ORX52800.1 - 4.9e-07 29.9 0.5 0.028 14.7 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX52800.1 - 2.2e-06 27.8 13.7 0.025 15.0 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat COX7a PF02238.15 ORX52801.1 - 0.13 12.7 5.1 0.81 10.1 1.2 3.5 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VII Glyco_transf_15 PF01793.16 ORX52802.1 - 9.1e-107 357.1 14.5 1.1e-106 356.8 14.5 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DALR_1 PF05746.15 ORX52803.1 - 3.1e-14 53.2 0.1 8.2e-13 48.6 0.0 2.4 2 0 0 2 2 2 1 DALR anticodon binding domain Effector_1 PF04518.12 ORX52803.1 - 0.33 10.0 0.6 5.5 6.0 0.0 2.2 2 0 0 2 2 2 0 Effector from type III secretion system Aa_trans PF01490.18 ORX52804.1 - 1.1e-46 159.5 28.9 1.2e-46 159.2 28.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2631 PF10939.8 ORX52804.1 - 0.26 11.2 4.9 7.1 6.6 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2631) PRELI PF04707.14 ORX52805.1 - 1e-40 139.1 0.0 1.3e-40 138.8 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family bZIP_1 PF00170.21 ORX52806.1 - 3.1e-08 33.6 18.4 3.9e-07 30.1 18.4 2.3 1 1 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 ORX52806.1 - 1.6e-05 24.9 9.3 1.6e-05 24.9 9.3 3.2 2 1 0 3 3 3 2 Transcription factor PAP1 bZIP_2 PF07716.15 ORX52806.1 - 0.00022 21.2 18.7 0.0063 16.6 6.5 2.6 2 0 0 2 2 2 2 Basic region leucine zipper HJURP_mid PF12346.8 ORX52806.1 - 0.0069 16.8 1.6 0.017 15.6 1.6 1.6 1 0 0 1 1 1 1 Holliday junction recognition protein-associated repeat ACCA PF03255.14 ORX52806.1 - 0.019 14.8 3.1 0.056 13.3 3.1 1.7 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Glutaredoxin2_C PF04399.13 ORX52806.1 - 0.12 12.2 1.4 0.28 11.0 1.4 1.6 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GIT_CC PF16559.5 ORX52806.1 - 0.17 11.8 4.7 0.64 9.9 4.2 2.3 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Atg14 PF10186.9 ORX52806.1 - 0.29 10.2 8.8 0.49 9.4 8.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fzo_mitofusin PF04799.13 ORX52806.1 - 0.89 9.1 3.1 1.9 8.0 3.1 1.5 1 0 0 1 1 1 0 fzo-like conserved region DUF2524 PF10732.9 ORX52806.1 - 1 9.7 12.0 0.15 12.4 7.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) FapA PF03961.13 ORX52806.1 - 2.7 6.5 8.3 4.6 5.7 8.1 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 ORX52806.1 - 8 6.3 13.8 3.5 7.5 4.4 2.7 1 1 1 2 2 2 0 Septum formation initiator DUF1688 PF07958.11 ORX52807.1 - 1.1e-94 317.6 0.0 1.4e-94 317.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) MMS19_N PF14500.6 ORX52808.1 - 3.9e-95 318.3 12.5 1.7e-93 313.0 0.1 5.0 4 2 1 6 6 6 2 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 ORX52808.1 - 2.7e-91 306.8 28.4 1.7e-89 300.9 16.2 4.1 3 2 2 5 5 5 2 RNAPII transcription regulator C-terminal HEAT_2 PF13646.6 ORX52808.1 - 3.5e-05 24.1 7.8 0.06 13.7 1.7 5.6 4 1 1 5 5 5 2 HEAT repeats HEAT PF02985.22 ORX52808.1 - 0.00017 21.6 6.4 0.019 15.2 0.2 5.9 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 ORX52808.1 - 0.00017 22.0 18.6 0.0062 17.0 0.8 7.1 5 1 3 8 8 8 3 HEAT-like repeat HEAT_PBS PF03130.16 ORX52808.1 - 0.011 16.4 0.4 53 4.9 0.0 4.8 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat IFRD PF05004.13 ORX52808.1 - 2.6 7.1 12.5 4.2 6.4 0.1 4.6 6 0 0 6 6 6 0 Interferon-related developmental regulator (IFRD) Cnd1 PF12717.7 ORX52808.1 - 7.2 6.6 17.9 9 6.3 0.9 5.5 5 1 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 DUF966 PF06136.13 ORX52809.1 - 1.6 8.3 9.5 2.7 7.6 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) C2 PF00168.30 ORX52810.1 - 4e-77 255.1 3.3 9.2e-19 67.6 0.0 6.3 6 0 0 6 6 6 5 C2 domain DUF4497 PF14924.6 ORX52810.1 - 0.0087 16.5 0.1 5.7 7.5 0.0 3.0 3 0 0 3 3 3 2 Protein of unknown function (DUF4497) Pectate_lyase_3 PF12708.7 ORX52811.1 - 2.6e-98 328.1 20.9 1.4e-82 276.7 4.2 3.8 4 1 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 ORX52811.1 - 1.5e-07 31.0 0.2 0.00039 20.1 0.0 2.5 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase Period_C PF12114.8 ORX52811.1 - 2 8.0 6.7 0.11 12.1 0.2 2.2 2 0 0 2 2 2 0 Period protein 2/3C-terminal region Ribosomal_L4 PF00573.22 ORX52812.1 - 1.5e-38 132.4 1.3 2.8e-38 131.6 1.3 1.4 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ORX52812.1 - 5.1e-31 106.5 3.5 8.1e-31 105.9 1.2 2.2 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain Ribosomal_S17e PF00833.18 ORX52813.1 - 1.1e-62 209.3 0.1 1.3e-62 209.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal S17 DPM3 PF08285.11 ORX52814.1 - 2.1e-33 114.3 0.1 2.3e-33 114.2 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Chlor_dismutase PF06778.12 ORX52814.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Chlorite dismutase DPM2 PF07297.12 ORX52815.1 - 1.2e-25 89.6 4.5 1.3e-25 89.5 4.5 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) PIG-P PF08510.12 ORX52815.1 - 0.0018 18.2 3.9 0.002 18.0 3.9 1.0 1 0 0 1 1 1 1 PIG-P MBOAT PF03062.19 ORX52816.1 - 1.6e-35 123.1 15.8 7.1e-35 121.0 15.6 2.0 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SCAMP PF04144.13 ORX52817.1 - 4.5e-49 167.1 19.8 5.5e-49 166.8 19.8 1.1 1 0 0 1 1 1 1 SCAMP family DUF3552 PF12072.8 ORX52817.1 - 0.024 14.1 5.9 0.024 14.1 5.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) CDC45 PF02724.14 ORX52817.1 - 0.05 11.9 0.0 0.068 11.5 0.0 1.2 1 0 0 1 1 1 0 CDC45-like protein NCE101 PF11654.8 ORX52817.1 - 0.11 12.3 0.1 0.26 11.0 0.1 1.6 1 0 0 1 1 1 0 Non-classical export protein 1 DUF3611 PF12263.8 ORX52817.1 - 0.24 11.3 5.1 5.7 6.8 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) DUF2070 PF09843.9 ORX52817.1 - 5.4 5.2 9.5 7.1 4.8 9.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ABC_membrane_2 PF06472.15 ORX52818.1 - 7.6e-98 327.2 5.9 1.1e-97 326.7 5.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX52818.1 - 1.1e-16 61.5 0.0 3.7e-16 59.9 0.0 1.9 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 ORX52818.1 - 0.0053 17.3 0.0 0.016 15.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain RuvB_N PF05496.12 ORX52818.1 - 0.01 15.6 0.0 0.034 13.9 0.0 1.9 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_21 PF13304.6 ORX52818.1 - 0.016 15.0 0.0 0.075 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX52818.1 - 0.019 15.5 1.3 0.51 10.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ORX52818.1 - 0.02 14.9 0.0 0.087 12.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ORX52818.1 - 0.028 14.9 0.0 0.061 13.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ORX52818.1 - 0.028 13.8 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ORX52818.1 - 0.045 14.1 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX52818.1 - 0.056 13.7 0.0 0.16 12.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ORX52818.1 - 0.076 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 ORX52818.1 - 0.1 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain SMC_N PF02463.19 ORX52818.1 - 0.19 11.1 0.0 2.6 7.4 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PHD PF00628.29 ORX52819.1 - 7.2e-09 35.4 12.7 1.3e-08 34.6 12.7 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX52819.1 - 0.00038 19.9 7.7 0.00064 19.2 7.7 1.4 1 0 0 1 1 1 1 PHD-finger zf-CW PF07496.15 ORX52819.1 - 0.0034 17.4 6.1 0.0078 16.2 6.1 1.6 1 0 0 1 1 1 1 CW-type Zinc Finger Polysacc_deac_1 PF01522.21 ORX52821.1 - 1.6e-23 82.9 0.0 3.7e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase DHDPS PF00701.22 ORX52821.1 - 0.0091 14.7 0.0 0.18 10.5 0.0 2.1 1 1 1 2 2 2 2 Dihydrodipicolinate synthetase family ELMO_CED12 PF04727.13 ORX52822.1 - 1.4e-42 145.8 0.9 2.1e-42 145.2 0.9 1.3 1 0 0 1 1 1 1 ELMO/CED-12 family Sulfotransfer_1 PF00685.27 ORX52822.1 - 0.082 12.4 1.0 4.8 6.6 0.1 2.7 2 1 1 3 3 3 0 Sulfotransferase domain DUF3827 PF12877.7 ORX52823.1 - 0.066 11.6 6.0 0.079 11.3 6.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Ndc1_Nup PF09531.10 ORX52823.1 - 0.77 8.4 3.7 0.81 8.3 3.7 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 ORX52823.1 - 3.9 5.7 5.2 4.5 5.5 5.2 1.0 1 0 0 1 1 1 0 Menin DUF3808 PF10300.9 ORX52824.1 - 2.7e-85 286.9 11.6 4.1e-44 151.1 0.4 2.9 3 0 0 3 3 3 2 Protein of unknown function (DUF3808) TPR_MalT PF17874.1 ORX52824.1 - 0.017 14.5 2.4 0.59 9.4 0.3 3.0 3 0 0 3 3 3 0 MalT-like TPR region TPR_2 PF07719.17 ORX52824.1 - 0.083 13.0 3.9 36 4.8 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Myticin-prepro PF10690.9 ORX52824.1 - 0.14 12.4 0.2 0.29 11.4 0.2 1.5 1 0 0 1 1 1 0 Myticin pre-proprotein from the mussel Coiled-coil_56 PF09813.9 ORX52824.1 - 0.16 12.1 1.3 0.58 10.2 0.3 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 MFS_1 PF07690.16 ORX52826.1 - 7.5e-36 123.8 14.3 7.5e-36 123.8 14.3 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily STE PF02200.16 ORX52827.1 - 0.041 14.3 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 STE like transcription factor PRIMA1 PF16101.5 ORX52827.1 - 8.6 6.4 10.5 9 6.4 0.3 2.5 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 KH_1 PF00013.29 ORX52828.1 - 2e-47 158.9 11.6 9.2e-19 67.1 0.3 3.7 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 ORX52828.1 - 2.9e-14 52.6 8.3 0.00032 20.5 0.2 3.5 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 ORX52828.1 - 2.6e-13 49.6 3.5 8.5e-06 25.6 0.1 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 ORX52828.1 - 4.6e-05 23.4 4.9 0.042 13.9 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 ORX52828.1 - 0.053 13.5 0.0 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 KH-like RNA-binding domain E1-E2_ATPase PF00122.20 ORX52830.1 - 1.3e-10 41.1 0.5 8.5e-10 38.4 0.5 2.2 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX52830.1 - 4e-06 27.3 0.7 0.0035 17.7 0.2 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX52830.1 - 0.0033 17.5 0.0 0.0085 16.2 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX52830.1 - 0.016 14.9 1.9 0.088 12.5 0.0 2.9 3 0 0 3 3 3 0 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX52830.1 - 0.15 11.8 0.1 0.35 10.6 0.1 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Tubulin_3 PF14881.6 ORX52832.1 - 1.5e-40 138.8 0.0 1.5e-39 135.6 0.0 2.1 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 ORX52832.1 - 8.1e-33 113.2 0.0 1.6e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 ORX52832.1 - 2.9e-11 44.0 0.0 1.2e-06 28.9 0.0 2.4 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Gcd10p PF04189.13 ORX52833.1 - 4.1e-77 259.3 2.3 5.7e-77 258.8 2.3 1.1 1 0 0 1 1 1 1 Gcd10p family AAA PF00004.29 ORX52834.1 - 1.2e-14 54.9 0.0 8.9e-14 52.0 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 ORX52834.1 - 7.6e-12 45.6 0.0 1.2e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA_11 PF13086.6 ORX52834.1 - 0.00035 20.5 0.0 0.00064 19.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ORX52834.1 - 0.0021 17.8 0.0 0.0054 16.5 0.0 1.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX52834.1 - 0.0021 18.4 0.0 0.0067 16.8 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX52834.1 - 0.0029 17.6 0.1 0.012 15.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX52834.1 - 0.024 14.9 0.0 0.058 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX52834.1 - 0.032 13.7 0.2 0.096 12.2 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 ORX52834.1 - 0.036 14.0 0.4 0.12 12.3 0.0 2.1 3 0 0 3 3 2 0 NACHT domain RNA_helicase PF00910.22 ORX52834.1 - 0.038 14.4 0.0 0.097 13.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase SRI PF08236.11 ORX52834.1 - 0.044 14.0 0.0 0.87 9.8 0.0 2.9 3 1 0 3 3 3 0 SRI (Set2 Rpb1 interacting) domain AAA_33 PF13671.6 ORX52834.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_6 PF12774.7 ORX52834.1 - 0.069 12.1 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region AAA_25 PF13481.6 ORX52834.1 - 0.077 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX52834.1 - 0.09 12.5 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX52834.1 - 0.094 12.3 0.0 0.21 11.1 0.0 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 ORX52834.1 - 0.12 12.4 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zn_clus PF00172.18 ORX52835.1 - 2e-08 34.2 7.3 4.5e-08 33.1 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX52835.1 - 8e-05 21.8 2.9 0.00014 21.0 2.9 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain HBM PF16591.5 ORX52836.1 - 0.0022 17.5 5.2 0.0022 17.5 5.2 2.3 1 1 1 2 2 2 2 Helical bimodular sensor domain IKKbetaNEMObind PF12179.8 ORX52836.1 - 0.07 13.2 4.0 0.14 12.2 1.2 2.7 2 0 0 2 2 2 0 I-kappa-kinase-beta NEMO binding domain PTPA PF03095.15 ORX52836.1 - 0.1 12.0 3.0 0.16 11.4 3.0 1.4 1 0 0 1 1 1 0 Phosphotyrosyl phosphate activator (PTPA) protein DUF4201 PF13870.6 ORX52836.1 - 0.11 12.2 25.1 0.26 11.0 24.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) FUSC PF04632.12 ORX52836.1 - 0.2 10.1 5.5 0.26 9.8 5.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family PIN_12 PF16289.5 ORX52836.1 - 0.33 11.4 6.3 0.65 10.5 6.3 1.6 1 0 0 1 1 1 0 PIN domain Flagellin_N PF00669.20 ORX52836.1 - 0.38 10.9 9.2 0.39 10.8 5.9 2.2 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region Lebercilin PF15619.6 ORX52836.1 - 0.42 10.3 33.0 0.014 15.0 26.1 2.1 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DcpS PF05652.12 ORX52836.1 - 0.51 11.2 3.6 0.59 11.0 1.9 2.1 1 1 1 2 2 2 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal DUF4407 PF14362.6 ORX52836.1 - 0.69 9.2 18.2 1.1 8.6 18.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HMMR_N PF15905.5 ORX52836.1 - 2 7.8 28.6 3.4 7.0 13.6 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal zf-C4H2 PF10146.9 ORX52836.1 - 3.7 7.8 23.0 1.6 9.0 20.0 1.8 1 1 2 3 3 3 0 Zinc finger-containing protein YnfE PF17452.2 ORX52836.1 - 4.3 7.7 7.9 16 5.9 0.9 2.6 2 0 0 2 2 2 0 Uncharacterized YnfE-like EPL1 PF10513.9 ORX52836.1 - 5.5 7.4 20.5 25 5.2 20.6 1.9 1 1 0 1 1 1 0 Enhancer of polycomb-like AFG1_ATPase PF03969.16 ORX52837.1 - 1.8e-105 352.8 2.7 1.9e-99 333.0 1.0 2.0 1 1 1 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 ORX52837.1 - 1.4e-05 25.5 0.9 0.037 14.4 0.0 2.9 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 ORX52837.1 - 0.00048 20.4 0.0 0.0016 18.8 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX52837.1 - 0.0036 17.3 0.0 0.012 15.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 ORX52837.1 - 0.0099 15.7 0.9 0.052 13.4 0.2 2.3 2 1 0 2 2 2 1 Bacterial dnaA protein AAA PF00004.29 ORX52837.1 - 0.011 16.1 0.2 0.11 13.0 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ORX52837.1 - 0.015 14.7 0.1 0.15 11.5 0.0 2.5 3 0 0 3 3 3 0 Bacterial TniB protein AAA_24 PF13479.6 ORX52837.1 - 0.032 13.9 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mrx7 PF10906.8 ORX52837.1 - 0.072 13.3 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 MIOREX complex component 7 NDT80_PhoG PF05224.12 ORX52838.1 - 1.7e-38 132.7 0.0 3.4e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Alg6_Alg8 PF03155.15 ORX52839.1 - 1.2e-159 532.4 34.8 1.4e-159 532.2 34.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Sugar_tr PF00083.24 ORX52840.1 - 3.9e-86 289.7 34.4 5.6e-45 154.0 12.2 2.0 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX52840.1 - 1.6e-26 93.1 38.1 8.5e-26 90.7 31.0 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Kinocilin PF15033.6 ORX52840.1 - 2.2 7.9 5.7 5.1 6.8 4.9 2.1 1 1 0 1 1 1 0 Kinocilin protein LIP PF03583.14 ORX52841.1 - 2e-78 263.6 0.0 2.6e-78 263.2 0.0 1.1 1 0 0 1 1 1 1 Secretory lipase Peptidase_S9 PF00326.21 ORX52841.1 - 0.0048 16.4 0.2 0.92 8.9 0.3 2.5 3 0 0 3 3 3 2 Prolyl oligopeptidase family CBM_21 PF03370.13 ORX52842.1 - 6.2e-27 94.0 0.0 8.4e-27 93.6 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ORX52842.1 - 3.6e-09 37.1 0.2 8.1e-09 35.9 0.2 1.5 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) Homeobox_KN PF05920.11 ORX52843.1 - 3.9e-19 68.3 0.4 7.8e-19 67.3 0.4 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX52843.1 - 5.1e-07 29.4 0.1 1.3e-06 28.1 0.1 1.8 1 0 0 1 1 1 1 Homeodomain RNase_PH PF01138.21 ORX52844.1 - 5.1e-38 130.6 0.0 6.9e-38 130.1 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX52844.1 - 9e-10 38.4 0.1 1.8e-09 37.5 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 FIST PF08495.10 ORX52845.1 - 6.9e-06 26.2 0.0 1.4e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 FIST N domain WD40 PF00400.32 ORX52846.1 - 1.9e-14 53.8 14.3 1.1e-06 29.2 0.2 6.8 6 0 0 6 6 6 3 WD domain, G-beta repeat WD40_like PF17005.5 ORX52846.1 - 0.0018 17.7 0.0 13 5.0 0.0 4.4 4 1 0 5 5 5 2 WD40-like domain CRT10 PF08728.10 ORX52847.1 - 8.5e-06 24.2 0.2 0.15 10.2 0.0 2.8 3 0 0 3 3 3 2 CRT10 WD40 PF00400.32 ORX52847.1 - 1.4e-05 25.8 1.6 9.1e-05 23.2 0.2 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX52847.1 - 0.002 18.4 0.0 0.46 10.8 0.0 3.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Zn_clus PF00172.18 ORX52848.1 - 1.4e-14 53.9 31.7 3.3e-10 39.9 11.1 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Cir_N PF10197.9 ORX52849.1 - 3.4e-05 23.9 4.4 3.4e-05 23.9 4.4 4.4 3 2 1 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR G-patch PF01585.23 ORX52850.1 - 9.1e-12 44.7 0.6 2.3e-11 43.4 0.6 1.7 1 0 0 1 1 1 1 G-patch domain FHA PF00498.26 ORX52850.1 - 1.1e-11 44.9 0.1 2.2e-11 43.9 0.1 1.5 1 0 0 1 1 1 1 FHA domain G-patch_2 PF12656.7 ORX52850.1 - 9.1e-06 25.7 0.8 2.8e-05 24.1 0.3 2.1 2 0 0 2 2 2 1 G-patch domain Yop-YscD_cpl PF16697.5 ORX52850.1 - 0.00023 21.4 0.0 0.00043 20.5 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Anti-TRAP PF15777.5 ORX52850.1 - 0.082 12.9 0.4 1.3 9.0 0.7 2.3 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein FAD_binding_7 PF03441.14 ORX52850.1 - 0.12 11.8 0.0 0.8 9.1 0.0 2.1 2 0 0 2 2 2 0 FAD binding domain of DNA photolyase HCNGP PF07818.13 ORX52851.1 - 8.4e-25 87.3 0.9 2.3e-24 85.9 0.2 2.0 2 0 0 2 2 2 1 HCNGP-like protein Chitin_synth_1 PF01644.17 ORX52852.1 - 4.2e-79 264.2 0.6 6.9e-79 263.5 0.6 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX52852.1 - 1.7e-23 82.4 0.0 3.8e-23 81.2 0.0 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX52852.1 - 1.6e-21 76.5 0.1 7.2e-15 54.6 0.0 3.1 2 1 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX52852.1 - 2.5e-08 34.1 12.5 1.3e-06 28.5 12.5 2.9 1 1 0 1 1 1 1 Glycosyl transferase family group 2 AAA_12 PF13087.6 ORX52853.1 - 1.1e-46 159.0 0.0 2.2e-46 158.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF2439 PF10382.9 ORX52853.1 - 4.7e-18 65.3 0.3 1.1e-17 64.1 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) AAA_11 PF13086.6 ORX52853.1 - 4.6e-13 49.6 0.1 9e-07 28.9 0.0 2.5 1 1 1 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ORX52853.1 - 0.0016 18.2 0.0 0.64 9.7 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Solute_trans_a PF03619.16 ORX52854.1 - 2.3e-38 132.3 8.7 2.7e-38 132.0 8.7 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF4199 PF13858.6 ORX52854.1 - 0.11 12.9 10.7 0.057 13.8 5.4 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF4199) Reeler PF02014.16 ORX52855.1 - 1.4e-05 25.9 0.0 2.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Reeler domain HisKA_7TM PF16927.5 ORX52855.1 - 0.075 13.1 0.5 0.1 12.6 0.0 1.4 2 0 0 2 2 2 0 N-terminal 7TM region of histidine kinase DUF3341 PF11821.8 ORX52855.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) Ldh_1_N PF00056.23 ORX52856.1 - 1.1e-37 129.2 2.8 1.6e-37 128.7 2.8 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 ORX52856.1 - 3.2e-23 82.5 0.2 1.3e-22 80.5 0.0 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain ApbA PF02558.16 ORX52856.1 - 0.00013 21.6 1.3 0.00062 19.4 1.3 2.1 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 ORX52856.1 - 0.0013 18.6 1.3 0.0022 17.9 1.3 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ORX52856.1 - 0.0036 17.9 2.8 0.016 15.8 1.7 2.5 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent Glyco_hydro_3_C PF01915.22 ORX52856.1 - 0.0058 16.6 0.6 0.0095 15.9 0.6 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain DAO PF01266.24 ORX52856.1 - 0.018 14.7 1.5 0.018 14.7 1.5 2.0 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX52856.1 - 0.021 14.1 0.3 0.037 13.2 0.2 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ORX52856.1 - 0.031 14.6 0.9 0.063 13.5 0.9 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 ORX52856.1 - 0.065 12.8 2.7 0.72 9.4 2.7 2.1 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SUIM_assoc PF16619.5 ORX52857.1 - 0.0011 19.0 0.0 0.013 15.5 0.0 3.0 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 EMG1 PF03587.14 ORX52858.1 - 3.3e-78 261.8 0.1 3.9e-78 261.6 0.1 1.1 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Ank_4 PF13637.6 ORX52859.1 - 6.3e-07 29.8 5.2 0.0019 18.7 0.2 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX52859.1 - 7.4e-07 29.7 0.4 1.3e-05 25.6 0.4 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ORX52859.1 - 0.00056 20.2 3.0 0.53 10.8 0.1 4.8 3 2 1 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ORX52859.1 - 0.001 19.3 0.4 0.057 13.7 0.1 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) F-box-like PF12937.7 ORX52859.1 - 0.011 15.6 1.7 0.031 14.1 1.7 1.8 1 1 0 1 1 1 0 F-box-like Ank_3 PF13606.6 ORX52859.1 - 0.24 12.1 0.9 99 4.0 0.0 4.4 4 1 1 5 5 5 0 Ankyrin repeat zf-CCHC_3 PF13917.6 ORX52860.1 - 7.5e-18 64.2 4.1 9.6e-18 63.9 4.1 1.2 1 0 0 1 1 1 1 Zinc knuckle CLIP1_ZNF PF16641.5 ORX52860.1 - 0.16 11.9 2.3 0.22 11.5 2.3 1.2 1 0 0 1 1 1 0 CLIP1 zinc knuckle Cofilin_ADF PF00241.20 ORX52861.1 - 3.3e-40 136.7 0.1 3.7e-40 136.5 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Sds3 PF08598.11 ORX52862.1 - 4.6e-08 33.3 10.2 4.6e-08 33.3 10.2 2.2 1 1 1 2 2 2 1 Sds3-like SPX PF03105.19 ORX52862.1 - 4.2 7.2 27.5 6 6.7 27.5 1.2 1 0 0 1 1 1 0 SPX domain FAM76 PF16046.5 ORX52862.1 - 4.9 6.4 15.3 6.4 6.0 15.3 1.4 1 0 0 1 1 1 0 FAM76 protein Creatinase_N_2 PF16189.5 ORX52863.1 - 2.1e-48 164.5 0.0 7.6e-48 162.6 0.0 1.9 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ORX52863.1 - 4.2e-43 147.5 0.0 5.8e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ORX52863.1 - 1.4e-24 85.9 0.0 6.8e-23 80.5 0.0 2.8 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ORX52863.1 - 3.7e-20 72.9 0.2 3e-17 63.5 0.0 2.5 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Ribosomal_L30_N PF08079.12 ORX52864.1 - 8.5e-27 93.2 14.1 1.6e-26 92.3 14.1 1.5 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 ORX52864.1 - 4.9e-18 64.7 1.2 9.4e-18 63.9 1.2 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e DUF2987 PF11205.8 ORX52867.1 - 0.06 13.3 0.1 0.084 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) Methyltransf_11 PF08241.12 ORX53044.1 - 7.5e-15 55.4 0.0 1.3e-14 54.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53044.1 - 1.3e-11 45.0 0.0 2.8e-11 44.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX53044.1 - 5.9e-06 26.2 0.0 8.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX53044.1 - 6e-06 26.1 0.0 9.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX53044.1 - 4e-05 23.1 0.0 0.00015 21.2 0.0 1.9 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX53044.1 - 5.2e-05 23.9 0.0 0.00021 22.0 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ORX53044.1 - 0.0049 16.5 0.0 0.0079 15.8 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 ORX53044.1 - 0.045 13.2 0.0 0.087 12.2 0.0 1.6 1 1 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_8 PF05148.15 ORX53044.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 1 0 1 1 1 0 Hypothetical methyltransferase DUF543 PF04418.12 ORX53045.1 - 0.045 13.8 0.6 0.053 13.5 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF543) MFS_1 PF07690.16 ORX53046.1 - 7.2e-28 97.5 42.0 3.1e-25 88.9 26.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ORX53046.1 - 0.00068 18.6 1.7 0.00068 18.6 1.7 2.9 2 1 0 3 3 3 2 MFS_1 like family Trehalase PF01204.18 ORX53048.1 - 7.3e-127 424.3 5.6 5.7e-126 421.3 5.6 1.9 1 1 0 1 1 1 1 Trehalase GDE_C PF06202.14 ORX53048.1 - 1.2e-05 24.5 1.4 3.3e-05 23.0 1.4 1.8 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Methyltransf_11 PF08241.12 ORX53049.1 - 4.9e-14 52.7 0.0 1.5e-13 51.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53049.1 - 2e-11 44.4 0.0 6.5e-11 42.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX53049.1 - 2.3e-10 40.6 0.0 3.4e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX53049.1 - 5.1e-07 29.6 0.1 1e-06 28.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX53049.1 - 7.4e-07 29.8 0.1 1.8e-06 28.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX53049.1 - 2.4e-06 27.1 0.1 3.9e-06 26.4 0.1 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 ORX53049.1 - 0.083 12.7 0.2 0.35 10.7 0.2 1.9 1 1 0 1 1 1 0 Hypothetical methyltransferase MTS PF05175.14 ORX53049.1 - 0.099 12.2 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Fibrillarin PF01269.17 ORX53050.1 - 1.1e-107 358.4 0.1 1.3e-107 358.1 0.1 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 ORX53050.1 - 8.5e-06 25.6 0.1 1.2e-05 25.1 0.1 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltr_RsmB-F PF01189.17 ORX53050.1 - 0.0043 16.7 0.0 0.012 15.3 0.0 1.7 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F PCMT PF01135.19 ORX53050.1 - 0.012 15.4 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ORX53050.1 - 0.044 13.6 0.0 0.083 12.7 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 ORX53050.1 - 0.067 13.3 0.1 0.095 12.8 0.1 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase DUF1977 PF09320.11 ORX53051.1 - 2.2e-28 98.6 0.4 4.3e-28 97.6 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 ORX53051.1 - 1.8e-23 82.4 0.5 3.4e-23 81.5 0.5 1.5 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 ORX53051.1 - 0.00068 19.6 0.0 0.0059 16.6 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53051.1 - 0.095 12.6 0.1 0.83 9.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DMAP_binding PF06464.11 ORX53052.1 - 1.7e-06 28.8 29.4 1e-05 26.3 22.5 3.6 2 1 0 2 2 2 1 DMAP1-binding Domain GvpG PF05120.12 ORX53052.1 - 0.00024 21.1 4.3 0.00024 21.1 4.3 1.6 2 0 0 2 2 2 1 Gas vesicle protein G SR-25 PF10500.9 ORX53052.1 - 0.011 15.4 2.5 0.011 15.4 2.5 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF5427 PF10310.9 ORX53052.1 - 2.4 7.0 15.6 0.067 12.2 9.4 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5427) MFS_1 PF07690.16 ORX53053.1 - 2.9e-23 82.4 53.2 4.9e-18 65.2 26.6 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily LapA_dom PF06305.11 ORX53053.1 - 2 8.3 12.6 0.15 11.9 1.0 3.4 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain SNF2_N PF00176.23 ORX53054.1 - 1.8e-65 221.0 1.0 6.9e-65 219.0 0.2 1.9 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX53054.1 - 6.6e-20 71.5 0.1 3.6e-19 69.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 ORX53054.1 - 5.1e-08 32.8 8.9 1.3e-07 31.6 8.9 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX53054.1 - 8.3e-08 32.0 8.8 1.6e-07 31.0 8.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX53054.1 - 3e-07 30.2 13.2 6.5e-07 29.1 13.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX53054.1 - 1.9e-06 28.1 11.4 5.8e-06 26.5 11.4 1.9 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 ORX53054.1 - 1.5e-05 25.0 0.0 4.7e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-RING_5 PF14634.6 ORX53054.1 - 2.2e-05 24.3 11.2 4.7e-05 23.3 11.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain DEAD PF00270.29 ORX53054.1 - 3.9e-05 23.5 0.0 0.00013 21.7 0.0 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 ORX53054.1 - 4.3e-05 23.3 13.5 0.00017 21.4 13.5 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX53054.1 - 0.00022 21.3 12.0 0.00044 20.3 12.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ORX53054.1 - 0.00074 19.3 10.8 0.0075 16.1 11.3 2.4 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ORX53054.1 - 0.08 12.7 10.4 0.2 11.5 10.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ORX53054.1 - 0.18 11.9 4.3 0.44 10.6 4.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Gin PF10764.9 ORX53054.1 - 0.4 10.7 4.4 1 9.4 4.4 1.7 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin zf-UDP PF14569.6 ORX53054.1 - 0.51 10.5 4.7 1.3 9.2 4.7 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-Nse PF11789.8 ORX53054.1 - 0.89 9.4 8.2 0.54 10.1 5.8 1.8 2 0 0 2 2 1 0 Zinc-finger of the MIZ type in Nse subunit Peptidase_S10 PF00450.22 ORX53055.1 - 3e-109 366.2 1.5 3.8e-109 365.9 1.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 ORX53055.1 - 0.036 13.3 0.0 5.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 SrfB PF07520.11 ORX53055.1 - 0.16 9.8 0.0 0.22 9.4 0.0 1.1 1 0 0 1 1 1 0 Virulence factor SrfB Aa_trans PF01490.18 ORX53056.1 - 1.6e-73 247.7 35.8 1.9e-73 247.5 35.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein OHCU_decarbox PF09349.10 ORX53057.1 - 3.4e-40 138.1 0.1 4e-40 137.8 0.1 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Septin PF00735.18 ORX53058.1 - 6.3e-58 196.3 0.2 6.9e-43 146.9 0.1 2.1 1 1 1 2 2 2 2 Septin MMR_HSR1 PF01926.23 ORX53058.1 - 3.2e-07 30.4 0.2 1.1e-06 28.6 0.2 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX53058.1 - 0.0007 19.2 0.0 0.014 15.0 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX53058.1 - 0.0012 19.2 0.0 0.008 16.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.17 ORX53058.1 - 0.0013 18.6 0.2 0.25 11.1 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 ORX53058.1 - 0.0018 17.8 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_33 PF13671.6 ORX53058.1 - 0.0098 16.1 1.1 0.034 14.3 0.5 2.4 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX53058.1 - 0.013 15.4 0.0 0.78 9.6 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 ORX53058.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 ORX53058.1 - 0.019 15.2 0.1 0.085 13.1 0.1 2.2 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX53058.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ORX53058.1 - 0.15 12.5 0.0 0.47 10.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase Roc PF08477.13 ORX53058.1 - 0.17 12.1 0.1 0.85 9.8 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 ORX53058.1 - 0.2 11.7 1.5 4.1 7.4 0.0 2.9 4 0 0 4 4 4 0 Dynamin family AAA_18 PF13238.6 ORX53058.1 - 0.81 10.2 2.7 1.3 9.6 0.0 2.6 3 1 1 4 4 3 0 AAA domain Peptidase_M17 PF00883.21 ORX53059.1 - 1.5e-118 395.6 0.0 2.3e-118 395.0 0.0 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 ORX53059.1 - 6.4e-14 51.9 0.6 1.2e-13 51.1 0.6 1.4 1 0 0 1 1 1 1 Cytosol aminopeptidase family, N-terminal domain Chitin_synth_2 PF03142.15 ORX53060.1 - 2.1e-240 798.8 1.5 3e-240 798.3 1.5 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX53060.1 - 2.8e-108 363.0 0.1 2e-98 330.4 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) DEK_C PF08766.11 ORX53060.1 - 1.8e-17 63.0 0.0 1.6e-16 60.0 0.0 2.4 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX53060.1 - 2.2e-11 44.1 0.0 4.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX53060.1 - 4.9e-11 42.9 2.5 4.9e-11 42.9 2.5 2.3 3 0 0 3 3 2 1 Glycosyl transferase family group 2 Cyt-b5 PF00173.28 ORX53060.1 - 1.9e-10 40.7 0.0 5.1e-05 23.3 0.0 2.8 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 ORX53060.1 - 0.00035 20.4 0.0 0.016 15.0 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 DUF87 PF01935.17 ORX53060.1 - 0.016 15.4 0.2 0.03 14.4 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain Glyco_transf_21 PF13506.6 ORX53060.1 - 0.017 14.6 0.1 0.052 13.0 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferase family 21 T2SSE PF00437.20 ORX53060.1 - 0.026 13.6 0.2 0.048 12.7 0.2 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ORX53060.1 - 0.032 14.5 0.1 0.096 13.0 0.1 1.8 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX53060.1 - 0.067 13.7 0.4 0.2 12.2 0.1 1.9 2 0 0 2 2 1 0 ABC transporter AAA_16 PF13191.6 ORX53060.1 - 0.083 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain SNF2_N PF00176.23 ORX53061.1 - 1.3e-55 188.6 1.0 2.7e-55 187.5 1.0 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX53061.1 - 2.2e-17 63.4 0.0 6.9e-17 61.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX53061.1 - 2.5e-09 37.4 0.0 6e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX53061.1 - 4.6e-05 22.7 5.7 0.00043 19.5 5.7 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DUF1087 PF06465.13 ORX53061.1 - 0.0001 22.2 0.2 0.00027 20.9 0.2 1.7 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1087) DEAD PF00270.29 ORX53061.1 - 0.00045 20.0 0.0 0.00093 19.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Chromo PF00385.24 ORX53061.1 - 0.00079 19.3 0.6 0.026 14.5 0.5 2.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain ERCC3_RAD25_C PF16203.5 ORX53061.1 - 0.002 17.4 0.0 0.004 16.4 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Velvet PF11754.8 ORX53062.1 - 4.8e-23 82.4 1.9 4.8e-23 82.4 1.9 1.8 1 1 1 2 2 2 1 Velvet factor Uso1_p115_head PF04869.14 ORX53063.1 - 2.3e-69 233.9 0.3 4.7e-69 232.9 0.3 1.6 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region Arm_vescicular PF18770.1 ORX53063.1 - 9.1e-06 25.5 0.5 2.5e-05 24.1 0.5 1.8 1 0 0 1 1 1 1 Armadillo tether-repeat of vescicular transport factor Atx10homo_assoc PF09759.9 ORX53063.1 - 0.003 17.6 0.5 10 6.2 0.0 4.3 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Lactamase_B_4 PF13691.6 ORX53063.1 - 0.18 11.5 0.0 0.5 10.1 0.0 1.7 1 0 0 1 1 1 0 tRNase Z endonuclease DnaJ PF00226.31 ORX53064.1 - 0.045 13.9 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 DnaJ domain M16C_assoc PF08367.11 ORX53065.1 - 4e-77 258.7 0.2 7.9e-77 257.8 0.2 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 ORX53065.1 - 5.9e-33 114.4 0.2 4.7e-26 91.9 0.1 3.3 3 0 0 3 3 3 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX53065.1 - 1.1e-07 32.0 0.1 5.4e-05 23.2 0.0 3.5 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) NETI PF14044.6 ORX53065.1 - 0.04 13.6 0.0 0.099 12.4 0.0 1.6 1 0 0 1 1 1 0 NETI protein DUF2312 PF10073.9 ORX53065.1 - 0.45 10.2 2.4 0.79 9.4 0.3 2.5 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) Inhibitor_I29 PF08246.12 ORX53067.1 - 0.086 13.3 0.0 0.24 11.9 0.0 1.7 1 0 0 1 1 1 0 Cathepsin propeptide inhibitor domain (I29) NUC130_3NT PF08158.12 ORX53067.1 - 0.09 13.1 1.2 0.34 11.2 0.0 2.5 3 0 0 3 3 3 0 NUC130/3NT domain ICL PF00463.21 ORX53068.1 - 2.2e-259 861.3 3.3 2.5e-259 861.1 3.3 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ORX53068.1 - 7.4e-10 38.7 0.7 1.4e-09 37.8 0.4 1.7 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase DUF1281_C PF18406.1 ORX53068.1 - 0.11 12.2 0.1 0.27 11.0 0.1 1.5 1 0 0 1 1 1 0 Ferredoxin-like domain in Api92-like protein Topoisom_bac PF01131.20 ORX53069.1 - 3.1e-103 346.0 0.0 3.7e-103 345.7 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 ORX53069.1 - 3.4e-17 62.5 0.0 5.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Toprim domain zf-GRF PF06839.12 ORX53069.1 - 3.1e-12 46.4 6.3 8.8e-12 44.9 6.3 1.9 1 0 0 1 1 1 1 GRF zinc finger FKBP_C PF00254.28 ORX53070.1 - 4.1e-21 75.1 0.0 8.3e-21 74.1 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 PF00515.28 ORX53070.1 - 1.2e-17 62.9 3.6 5.1e-05 22.9 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX53070.1 - 7e-11 41.4 1.1 0.0013 18.7 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX53070.1 - 4.4e-10 39.1 3.5 0.0008 19.1 0.2 3.6 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 ORX53070.1 - 5.3e-08 32.5 3.0 8.1e-05 22.5 0.2 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX53070.1 - 5.7e-08 32.9 2.1 4.8e-06 26.8 0.5 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX53070.1 - 2.6e-07 30.2 2.4 0.042 13.9 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX53070.1 - 7.6e-06 26.1 3.1 2.6e-05 24.4 3.3 1.8 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ORX53070.1 - 7.8e-06 26.2 2.6 0.11 13.1 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX53070.1 - 2.9e-05 24.5 0.0 0.16 12.9 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX53070.1 - 4.6e-05 23.8 1.9 0.0015 19.0 0.1 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53070.1 - 0.00013 22.5 0.0 0.035 14.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX53070.1 - 0.00039 20.6 1.9 0.011 16.1 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 ORX53070.1 - 0.0064 16.2 2.5 0.054 13.2 0.2 2.5 1 1 2 3 3 3 1 26S proteasome subunit RPN7 Paf67 PF10255.9 ORX53070.1 - 0.0099 14.9 0.1 0.039 12.9 0.1 1.8 1 1 0 1 1 1 1 RNA polymerase I-associated factor PAF67 FKBP_N_2 PF18023.1 ORX53070.1 - 0.01 15.9 0.1 0.074 13.1 0.0 2.3 2 1 0 2 2 2 0 BDBT FKBP like N-terminal TPR_9 PF13371.6 ORX53070.1 - 0.024 14.8 0.0 0.066 13.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF357 PF04010.13 ORX53070.1 - 0.034 14.2 2.3 3.9 7.6 0.1 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF357) TPR_10 PF13374.6 ORX53070.1 - 0.054 13.4 0.5 23 5.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SMG1 PF15785.5 ORX53070.1 - 0.057 11.8 0.1 0.068 11.5 0.1 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 MIT PF04212.18 ORX53070.1 - 0.69 10.0 4.4 4.3 7.5 0.9 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Sulfate_transp PF00916.20 ORX53071.1 - 5e-107 357.9 23.9 6.7e-107 357.5 23.9 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX53071.1 - 7.3e-08 32.1 0.0 1.3e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX53071.1 - 0.0041 17.5 3.4 0.0041 17.5 3.4 3.2 2 2 0 2 2 2 1 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 ORX53071.1 - 0.0057 17.0 0.3 0.01 16.1 0.3 1.4 1 0 0 1 1 1 1 STAS domain TMEM65 PF10507.9 ORX53071.1 - 0.029 14.3 0.3 4.3 7.3 0.1 2.8 2 0 0 2 2 2 0 Transmembrane protein 65 G-patch_2 PF12656.7 ORX53072.1 - 1.1e-19 70.3 0.3 2.9e-19 68.9 0.3 1.8 1 0 0 1 1 1 1 G-patch domain G-patch PF01585.23 ORX53072.1 - 0.0061 16.4 0.6 0.013 15.3 0.6 1.6 1 0 0 1 1 1 1 G-patch domain bZIP_1 PF00170.21 ORX53073.1 - 1.4e-10 41.1 12.1 2.7e-10 40.2 12.1 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX53073.1 - 1.7e-07 31.2 13.9 1.7e-07 31.2 13.9 2.2 2 1 1 3 3 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX53073.1 - 1.5e-06 28.6 9.5 1.5e-06 28.6 9.5 2.2 2 0 0 2 2 2 1 bZIP Maf transcription factor Rootletin PF15035.6 ORX53073.1 - 0.0016 18.5 6.2 0.0016 18.5 6.2 1.8 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion Lipoprotein_20 PF13942.6 ORX53073.1 - 0.01 15.8 7.1 0.02 14.9 7.1 1.4 1 0 0 1 1 1 0 YfhG lipoprotein FliD_N PF02465.18 ORX53073.1 - 0.023 15.4 1.0 0.74 10.5 0.1 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DivIVA PF05103.13 ORX53073.1 - 0.031 14.3 1.8 0.031 14.3 1.8 1.8 2 0 0 2 2 2 0 DivIVA protein INTS5_N PF14837.6 ORX53073.1 - 0.11 12.1 1.9 0.57 9.7 0.1 2.4 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus GCR1_C PF12550.8 ORX53073.1 - 0.21 11.9 2.3 0.41 11.0 2.3 1.4 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes DUF1664 PF07889.12 ORX53073.1 - 0.22 11.6 1.0 0.58 10.2 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Ribosomal_S20p PF01649.18 ORX53073.1 - 0.39 11.4 3.0 1 10.1 3.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S20 Mto2_bdg PF12808.7 ORX53073.1 - 0.93 9.8 11.1 0.65 10.3 7.3 2.7 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region UPF0242 PF06785.11 ORX53073.1 - 0.95 9.5 10.7 0.034 14.2 4.4 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus MRP-L28 PF09812.9 ORX53073.1 - 2 8.5 10.3 0.075 13.2 3.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 DUF1640 PF07798.11 ORX53073.1 - 2.7 8.0 10.5 0.12 12.5 3.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) ATG27 PF09451.10 ORX53074.1 - 1.3e-41 143.3 0.0 1.5e-41 143.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 ORX53074.1 - 0.0014 17.8 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor CIMR PF00878.18 ORX53074.1 - 0.015 15.4 0.0 1.9 8.6 0.1 2.2 2 0 0 2 2 2 0 Cation-independent mannose-6-phosphate receptor repeat CDC50 PF03381.15 ORX53075.1 - 3.5e-84 282.6 0.3 4.2e-84 282.4 0.3 1.0 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family MIOX PF05153.15 ORX53076.1 - 1.1e-105 352.7 9.2 1.3e-105 352.5 9.2 1.0 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 ORX53076.1 - 0.12 12.6 2.4 0.42 10.8 0.1 2.6 2 1 1 3 3 3 0 HD domain Ank_4 PF13637.6 ORX53077.1 - 6.9e-21 74.4 0.3 1.1e-10 41.8 0.0 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX53077.1 - 8.2e-17 59.6 0.0 2.4e-05 24.4 0.0 3.1 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ORX53077.1 - 3.3e-16 59.6 0.0 4.8e-16 59.1 0.0 1.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX53077.1 - 1.8e-14 53.4 0.5 2.2e-06 27.9 0.1 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX53077.1 - 2.9e-13 49.8 0.8 3.2e-10 40.1 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) NAD_binding_1 PF00175.21 ORX53078.1 - 9e-28 97.1 0.0 1.7e-27 96.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ORX53078.1 - 9.1e-26 90.1 0.0 1.9e-25 89.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ORX53078.1 - 2.9e-06 27.5 0.0 0.00011 22.4 0.0 2.9 3 0 0 3 3 3 1 Ferric reductase NAD binding domain zf-U1 PF06220.12 ORX53079.1 - 1.7e-07 30.9 2.7 3.1e-07 30.0 2.7 1.5 1 0 0 1 1 1 1 U1 zinc finger DUF4630 PF15443.6 ORX53079.1 - 0.16 12.2 4.7 0.24 11.6 4.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4630) NTP_transferase PF00483.23 ORX53080.1 - 2.4e-52 178.0 0.0 3.4e-52 177.5 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ORX53080.1 - 3.1e-13 48.9 10.2 1.1e-10 40.8 0.9 4.0 2 1 2 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX53080.1 - 5.3e-11 43.1 0.0 2e-10 41.3 0.0 1.8 2 0 0 2 2 2 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 ORX53080.1 - 2e-05 24.2 1.1 2e-05 24.2 1.1 3.0 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 ORX53080.1 - 0.054 11.6 0.1 0.075 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Sugar_tr PF00083.24 ORX53081.1 - 5.7e-110 368.3 22.4 6.7e-110 368.0 22.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX53081.1 - 2e-16 59.9 42.0 1e-12 47.7 16.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF697 PF05128.12 ORX53081.1 - 0.067 12.9 1.5 0.2 11.4 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Disaggr_repeat PF06848.11 ORX53082.1 - 0.015 15.0 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Disaggregatase related repeat DUF3472 PF11958.8 ORX53084.1 - 1e-27 97.7 2.3 1.7e-27 97.0 2.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3472) DUF5077 PF16871.5 ORX53084.1 - 9.3e-12 45.2 0.6 1.5e-11 44.5 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5077) TPR_2 PF07719.17 ORX53085.1 - 1.2e-29 100.0 29.6 1e-05 25.3 0.0 10.4 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53085.1 - 1.1e-27 94.7 34.7 2.3e-07 30.3 0.0 10.3 10 0 0 10 10 10 6 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX53085.1 - 3e-20 72.2 39.3 6.6e-20 71.1 4.0 6.1 3 1 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ORX53085.1 - 5.3e-19 66.8 25.7 1.7e-06 27.7 0.0 9.0 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 ORX53085.1 - 2e-15 56.8 29.2 8e-05 22.9 0.4 8.8 5 3 3 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53085.1 - 5.6e-14 52.5 3.4 0.00052 20.6 0.0 5.8 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX53085.1 - 1.2e-13 50.6 7.7 0.073 13.9 0.0 7.8 6 1 3 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX53085.1 - 1.3e-09 37.6 19.3 2.4e-05 23.9 0.0 7.2 5 2 2 7 7 7 3 TPR repeat TPR_19 PF14559.6 ORX53085.1 - 3.7e-09 37.0 18.7 0.26 11.8 1.3 7.0 6 2 2 8 8 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 ORX53085.1 - 1.9e-08 33.7 24.0 1.2e-05 24.9 0.0 8.1 8 1 1 9 9 9 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX53085.1 - 3.2e-06 27.4 15.2 1.6 9.5 0.0 8.1 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX53085.1 - 1.8e-05 24.8 21.2 1.7 9.2 0.1 8.0 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX53085.1 - 8.5e-05 22.6 7.2 0.13 12.5 0.0 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 ORX53085.1 - 0.00024 20.4 12.2 0.46 9.7 0.2 4.7 1 1 2 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX53085.1 - 0.0028 17.5 18.5 3.2 7.7 0.0 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat Coatomer_E PF04733.14 ORX53085.1 - 0.0084 15.6 2.4 1.3 8.4 0.1 4.0 4 0 0 4 4 4 1 Coatomer epsilon subunit MADF_DNA_bdg PF10545.9 ORX53085.1 - 0.11 12.8 1.1 1.8 8.9 0.1 2.6 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like NRBF2_MIT PF17169.4 ORX53085.1 - 1.4 9.2 4.5 4.9 7.5 0.1 3.6 3 1 1 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 Fis1_TPR_C PF14853.6 ORX53085.1 - 2.4 8.3 15.4 9.6 6.4 0.4 5.4 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 ORX53085.1 - 6 7.0 17.2 0.98 9.5 0.1 4.7 5 0 0 5 5 4 0 Tetratricopeptide repeat Acetyltransf_10 PF13673.7 ORX53086.1 - 2.4e-13 50.1 0.0 4e-13 49.4 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX53086.1 - 5.1e-11 42.8 0.0 6.9e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX53086.1 - 6.9e-09 36.0 0.0 1.1e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX53086.1 - 0.00011 22.0 0.1 0.00017 21.5 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ORX53086.1 - 0.06 13.4 0.1 0.33 11.0 0.1 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain MgtE PF01769.16 ORX53087.1 - 1.4e-43 148.2 27.0 5.5e-23 81.7 3.9 3.6 4 0 0 4 4 4 3 Divalent cation transporter Gelsolin PF00626.22 ORX53088.1 - 2.7e-39 132.9 0.1 1.3e-12 47.4 0.1 3.2 3 0 0 3 3 3 3 Gelsolin repeat sCache_like PF16736.5 ORX53088.1 - 0.14 12.3 0.0 0.54 10.4 0.0 1.9 2 0 0 2 2 2 0 Single Cache-like DUF1752 PF08550.10 ORX53089.1 - 4.8e-12 45.5 0.4 8.6e-12 44.7 0.4 1.4 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) DUF3295 PF11702.8 ORX53089.1 - 0.0037 16.7 0.1 0.0037 16.7 0.1 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF3295) PBP1_TM PF14812.6 ORX53089.1 - 0.023 15.1 2.3 0.04 14.3 2.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Porin_10 PF14121.6 ORX53089.1 - 0.1 11.2 0.1 0.15 10.7 0.1 1.1 1 0 0 1 1 1 0 Putative porin Cyclin PF08613.11 ORX53090.1 - 1.2e-10 41.9 1.4 1.9e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 ORX53090.1 - 1.1e-06 28.4 0.0 1.1e-06 28.4 0.0 2.4 3 0 0 3 3 3 1 Cyclin, N-terminal domain Nop16 PF09420.10 ORX53090.1 - 0.04 13.9 1.0 0.067 13.2 1.0 1.2 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 DUF2870 PF11069.8 ORX53090.1 - 0.67 10.4 3.6 14 6.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2870) TFIIA PF03153.13 ORX53090.1 - 9 6.2 20.2 0.061 13.3 7.7 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Prion_bPrPp PF11587.8 ORX53091.1 - 0.69 9.8 4.6 1.9 8.4 4.6 1.8 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal CDP-OH_P_transf PF01066.21 ORX53092.1 - 7e-15 55.5 0.1 7e-15 55.5 0.1 4.3 4 1 0 4 4 4 1 CDP-alcohol phosphatidyltransferase MENTAL PF10457.9 ORX53092.1 - 0.52 10.1 5.6 0.45 10.3 1.1 2.4 2 0 0 2 2 2 0 Cholesterol-capturing domain NAD_binding_10 PF13460.6 ORX53093.1 - 4.3e-16 59.3 0.0 5.6e-16 59.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX53093.1 - 1.7e-13 50.7 0.0 2.3e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ORX53093.1 - 5.6e-05 22.7 0.0 8.9e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 ORX53093.1 - 0.00066 19.2 0.0 0.0022 17.5 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ORX53093.1 - 0.03 13.6 0.1 0.27 10.5 0.0 2.3 1 1 1 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Semialdhyde_dh PF01118.24 ORX53093.1 - 0.032 14.7 0.2 0.082 13.4 0.2 1.8 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 ORX53093.1 - 0.036 13.1 0.0 0.052 12.5 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 ORX53093.1 - 0.059 13.6 0.0 0.095 13.0 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 ORX53093.1 - 0.069 13.6 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_4 PF07993.12 ORX53093.1 - 0.11 11.6 0.0 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 Male sterility protein Bact_lectin PF18483.1 ORX53095.1 - 2.9e-22 79.7 0.0 4.9e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial lectin Rad4 PF03835.15 ORX53095.1 - 8.3e-13 48.3 3.5 1.5e-12 47.4 3.5 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 ORX53095.1 - 2.8e-12 47.1 2.4 6.8e-12 45.8 0.2 2.5 2 0 0 2 2 2 1 Transglutaminase-like superfamily PAW PF04721.17 ORX53095.1 - 0.00065 19.5 0.3 0.0011 18.7 0.3 1.4 1 0 0 1 1 1 1 PNGase C-terminal domain, mannose-binding module PAW Lectin_leg-like PF03388.13 ORX53095.1 - 0.024 14.0 0.0 0.57 9.5 0.0 2.3 2 0 0 2 2 2 0 Legume-like lectin family Kinesin PF00225.23 ORX53097.1 - 1e-103 346.8 0.0 1e-103 346.8 0.0 2.4 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ORX53097.1 - 2.4e-22 79.5 0.9 1.2e-21 77.2 0.0 2.7 2 0 0 2 2 2 1 Microtubule binding Pox_A_type_inc PF04508.12 ORX53097.1 - 1.4 8.9 5.9 0.74 9.8 0.4 3.5 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat DUF1192 PF06698.11 ORX53097.1 - 1.5 8.9 21.9 0.098 12.7 0.4 6.2 7 0 0 7 7 7 0 Protein of unknown function (DUF1192) Putative_PNPOx PF01243.20 ORX53098.1 - 0.095 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Sin3a_C PF16879.5 ORX53099.1 - 1.9e-50 172.2 1.4 1.9e-50 172.2 1.4 3.1 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 ORX53099.1 - 2e-38 130.3 15.0 2.6e-16 59.5 0.0 4.7 4 0 0 4 4 4 4 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ORX53099.1 - 4.2e-37 126.2 1.3 1.2e-36 124.7 1.3 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor EBP50_C PF09007.11 ORX53099.1 - 1.3 10.0 9.8 0.2 12.7 4.0 2.7 2 0 0 2 2 2 0 EBP50, C-terminal AhpC-TSA PF00578.21 ORX53100.1 - 2.8e-31 108.0 0.0 3.7e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX53100.1 - 6.4e-13 48.7 0.0 8.1e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ORX53100.1 - 7.5e-10 38.5 0.0 1.5e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin PBP1_TM PF14812.6 ORX53101.1 - 4.5 7.7 8.5 5.9 7.3 8.5 1.4 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sugar_tr PF00083.24 ORX53102.1 - 4.7e-91 305.9 15.7 5e-51 174.0 9.9 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX53102.1 - 5.4e-25 88.1 43.5 1.7e-19 70.0 19.3 2.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Cyclin_N PF00134.23 ORX53102.1 - 0.00067 19.4 0.4 0.0042 16.8 0.0 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX53102.1 - 0.075 13.4 0.0 0.16 12.4 0.0 1.5 1 0 0 1 1 1 0 Cyclin TMEM174 PF15029.6 ORX53102.1 - 0.13 12.0 0.8 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein 174 Trp_oprn_chp PF09534.10 ORX53102.1 - 2.1 8.1 8.7 0.12 12.2 2.3 2.2 2 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) COPIIcoated_ERV PF07970.12 ORX53104.1 - 2.8e-36 125.4 0.1 4.1e-36 124.9 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ORX53104.1 - 1.2e-22 80.1 0.0 2.2e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Bac_export_2 PF01312.19 ORX53104.1 - 0.095 11.9 0.0 0.24 10.5 0.0 1.6 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family IncE PF17627.2 ORX53105.1 - 3.9 7.5 7.1 2.1 8.4 3.7 2.0 1 1 1 2 2 2 0 Inclusion membrane protein E Zip PF02535.22 ORX53106.1 - 4e-33 115.0 14.6 8.3e-33 114.0 14.6 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter DUF3021 PF11457.8 ORX53106.1 - 0.05 13.9 0.9 0.05 13.9 0.9 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3021) Protamine_P2 PF00841.19 ORX53106.1 - 1.6 9.3 7.5 1.4 9.4 5.6 1.8 1 1 1 2 2 2 0 Sperm histone P2 DUF3984 PF13136.6 ORX53106.1 - 2.7 7.3 13.7 3.9 6.8 13.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) Lip_prot_lig_C PF10437.9 ORX53107.1 - 9.5e-09 35.1 0.0 2.4e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus BPL_LplA_LipB PF03099.19 ORX53107.1 - 0.059 13.3 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 Biotin/lipoate A/B protein ligase family dCMP_cyt_deam_1 PF00383.23 ORX53108.1 - 1.8e-12 47.0 0.1 3.1e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX53108.1 - 5.4e-08 32.7 0.1 4.7e-07 29.6 0.1 2.1 1 1 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 ORX53108.1 - 5.4e-07 29.8 0.1 8.5e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Bd3614-like deaminase GEP5 PF17053.5 ORX53108.1 - 0.024 14.5 1.1 0.085 12.7 0.9 2.0 2 1 0 2 2 2 0 Genetic interactor of prohibitin 5 Lipase_3 PF01764.25 ORX53109.1 - 3.8e-12 46.3 0.0 8.2e-12 45.2 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) C2 PF00168.30 ORX53109.1 - 2.4e-05 24.5 0.0 4.8e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain XLF PF09302.11 ORX53111.1 - 0.065 13.4 0.2 0.087 13.0 0.2 1.2 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component NUP50 PF08911.11 ORX53113.1 - 0.0014 19.3 0.0 0.0033 18.0 0.0 1.6 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) Amidase PF01425.21 ORX53114.1 - 1.1e-118 397.1 0.0 1.3e-118 396.9 0.0 1.0 1 0 0 1 1 1 1 Amidase RhoGAP PF00620.27 ORX53115.1 - 7.9e-46 155.6 0.0 2.1e-45 154.2 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX53115.1 - 9.6e-15 54.6 25.8 1.4e-08 34.9 8.7 3.5 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 ORX53115.1 - 8.4e-06 25.6 12.8 8.4e-06 25.6 12.8 4.6 3 1 1 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) RE_R_Pab1 PF09522.10 ORX53115.1 - 0.049 13.7 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 R.Pab1 restriction endonuclease DUF2852 PF11014.8 ORX53115.1 - 8.8 6.5 11.8 0.93 9.7 0.9 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2852) Abhydrolase_3 PF07859.13 ORX53116.1 - 3.8e-34 118.4 0.0 6.3e-22 78.5 0.0 2.5 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX53116.1 - 0.012 14.5 0.0 0.021 13.7 0.0 1.3 1 0 0 1 1 1 0 Steryl acetyl hydrolase ORC4_C PF14629.6 ORX53117.1 - 3.8e-47 160.5 0.1 9.5e-47 159.2 0.0 1.6 2 0 0 2 2 2 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 ORX53117.1 - 2.2e-14 54.2 0.1 4.8e-14 53.1 0.1 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ORX53117.1 - 1.3e-07 32.1 0.0 3.2e-07 30.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX53117.1 - 2.7e-06 27.7 0.0 5.4e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ORX53117.1 - 0.00049 20.1 0.0 0.00096 19.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF815 PF05673.13 ORX53117.1 - 0.00095 18.4 0.0 0.0014 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ORX53117.1 - 0.013 15.1 0.0 0.027 14.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 ORX53117.1 - 0.021 14.7 0.0 0.036 14.0 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 ORX53117.1 - 0.047 13.7 0.0 0.23 11.5 0.0 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Bap31_Bap29_C PF18035.1 ORX53117.1 - 0.088 12.8 1.3 0.18 11.8 1.3 1.5 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain AAA_19 PF13245.6 ORX53117.1 - 0.11 12.8 0.1 0.15 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX53117.1 - 0.14 12.2 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ORX53117.1 - 0.15 12.5 0.0 0.52 10.7 0.0 2.0 1 1 0 1 1 1 0 RNA helicase Endonuclease_NS PF01223.23 ORX53119.1 - 5.8e-67 225.8 0.3 7e-67 225.6 0.3 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Retinal PF15449.6 ORX53119.1 - 0.22 9.3 1.6 0.28 8.9 1.6 1.1 1 0 0 1 1 1 0 Retinal protein KH_8 PF17903.1 ORX53120.1 - 4.3e-30 103.6 0.3 8.9e-30 102.6 0.0 1.7 2 0 0 2 2 2 1 Krr1 KH1 domain KH_1 PF00013.29 ORX53120.1 - 0.00021 21.0 0.0 0.00071 19.4 0.0 1.8 2 0 0 2 2 2 1 KH domain Pfg27 PF09216.10 ORX53120.1 - 0.026 14.4 0.1 0.053 13.4 0.1 1.5 1 0 0 1 1 1 0 Pfg27 GATA PF00320.27 ORX53121.1 - 0.024 14.2 2.7 0.053 13.1 2.7 1.6 1 0 0 1 1 1 0 GATA zinc finger WD40 PF00400.32 ORX53122.1 - 4.3e-44 147.6 19.1 6.7e-08 33.1 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX53122.1 - 3.2e-27 94.6 5.0 0.00094 19.4 0.0 6.1 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX53122.1 - 7.1e-09 35.1 8.3 0.043 12.8 0.8 5.8 1 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX53122.1 - 3.1e-08 33.7 4.0 0.00067 19.6 0.3 3.5 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ORX53122.1 - 6.8e-08 32.2 0.2 0.021 14.1 0.0 2.8 1 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ORX53122.1 - 3.4e-06 26.0 6.1 0.0089 14.7 0.2 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ORX53122.1 - 0.0002 20.4 6.3 0.059 12.3 0.1 4.1 1 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ORX53122.1 - 0.00037 19.1 0.8 0.16 10.5 0.0 2.8 1 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ORX53122.1 - 0.00038 20.3 0.3 17 5.5 0.1 4.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PHTB1_N PF14727.6 ORX53122.1 - 0.0038 16.6 0.6 4 6.7 0.0 3.0 1 1 1 2 2 2 2 PTHB1 N-terminus PQQ_3 PF13570.6 ORX53122.1 - 0.013 16.0 3.1 10 6.8 0.0 4.2 5 0 0 5 5 5 0 PQQ-like domain BAT PF15915.5 ORX53122.1 - 0.024 14.5 0.0 1.7 8.5 0.0 2.4 1 1 1 2 2 2 0 GAF and HTH_10 associated domain ArlS_N PF18719.1 ORX53122.1 - 0.062 13.5 0.2 5.4 7.2 0.0 3.0 2 1 0 3 3 3 0 ArlS sensor domain PQQ PF01011.21 ORX53122.1 - 0.083 12.9 3.9 7.8 6.6 0.0 4.2 4 0 0 4 4 4 0 PQQ enzyme repeat PH_9 PF15410.6 ORX53123.1 - 2.5e-10 40.8 0.0 7.2e-10 39.3 0.0 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX53123.1 - 8.8e-07 29.4 0.0 1.6e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 PH domain DUF1170 PF06663.13 ORX53123.1 - 0.047 13.4 0.1 0.077 12.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) MFS_1 PF07690.16 ORX53124.1 - 1.1e-21 77.2 32.6 1.1e-21 77.2 32.6 1.3 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4293 PF14126.6 ORX53124.1 - 0.53 10.5 4.3 0.53 10.5 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) PC_rep PF01851.22 ORX53124.1 - 4.3 8.0 5.4 11 6.7 0.0 2.8 2 0 0 2 2 2 0 Proteasome/cyclosome repeat Sec6 PF06046.13 ORX53125.1 - 1.9e-144 482.2 9.5 1.9e-144 482.2 9.5 1.7 2 0 0 2 2 2 1 Exocyst complex component Sec6 HsbA PF12296.8 ORX53125.1 - 0.12 12.8 1.4 1.8 9.0 0.7 2.5 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Peptidase_M24_C PF16188.5 ORX53125.1 - 0.12 12.4 0.4 1 9.5 0.1 2.6 3 0 0 3 3 3 0 C-terminal region of peptidase_M24 Syntaxin_2 PF14523.6 ORX53125.1 - 0.16 12.4 5.8 0.89 10.0 5.5 2.4 1 1 0 1 1 1 0 Syntaxin-like protein ELFV_dehydrog PF00208.21 ORX53127.1 - 4.2e-57 193.6 0.0 7.8e-57 192.8 0.0 1.5 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ORX53127.1 - 2.5e-24 85.0 0.0 2.8e-17 61.7 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 ORX53127.1 - 0.0089 15.9 0.0 0.11 12.4 0.0 2.3 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain FlbT PF07378.11 ORX53127.1 - 0.21 11.7 1.2 5.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Flagellar protein FlbT Longin PF13774.6 ORX53128.1 - 2.3e-28 98.1 0.0 3.5e-28 97.4 0.0 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ORX53128.1 - 1.6e-14 53.4 0.0 2.9e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 Synaptobrevin SLM4 PF16818.5 ORX53128.1 - 0.049 13.6 0.0 0.53 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein SLM4 Imm70 PF15601.6 ORX53128.1 - 0.085 12.4 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Immunity protein 70 Pkinase PF00069.25 ORX53129.1 - 8.9e-54 182.6 0.6 1.8e-53 181.6 0.6 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53129.1 - 1.2e-20 73.9 0.0 1.7e-20 73.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX53129.1 - 9.5e-05 22.4 0.0 0.00052 20.0 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX53129.1 - 0.0016 17.3 0.1 0.0016 17.3 0.1 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ORX53129.1 - 0.0039 16.6 1.0 0.012 15.0 0.1 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX53129.1 - 0.018 14.7 0.3 0.018 14.7 0.3 1.9 2 1 0 2 2 2 0 RIO1 family Choline_kinase PF01633.20 ORX53129.1 - 0.034 13.7 0.2 0.084 12.4 0.2 1.7 1 1 1 2 2 2 0 Choline/ethanolamine kinase YrbL-PhoP_reg PF10707.9 ORX53129.1 - 0.052 13.1 0.3 0.12 11.9 0.1 1.6 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL ABC1 PF03109.16 ORX53129.1 - 0.13 12.4 0.1 0.48 10.6 0.0 1.8 2 0 0 2 2 2 0 ABC1 family RSN1_7TM PF02714.15 ORX53130.1 - 9.2e-81 271.2 30.4 1.9e-80 270.1 30.4 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 ORX53130.1 - 1.2e-32 112.8 4.1 1.2e-32 112.8 4.1 2.6 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ORX53130.1 - 1.8e-31 109.7 0.0 5.2e-31 108.2 0.0 1.8 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter VanZ PF04892.12 ORX53132.1 - 1.6e-09 38.5 6.3 3e-09 37.6 6.3 1.4 1 1 0 1 1 1 1 VanZ like family TMCCDC2 PF15844.5 ORX53132.1 - 5.9 6.8 7.5 0.34 10.8 0.8 1.9 1 1 1 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 AIG1 PF04548.16 ORX53133.1 - 1.1e-06 28.1 0.1 1.4e-06 27.8 0.1 1.1 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ORX53133.1 - 0.16 12.1 0.0 0.28 11.3 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATG16 PF08614.11 ORX53134.1 - 0.0011 19.3 13.3 0.0011 19.3 13.3 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) IFT57 PF10498.9 ORX53134.1 - 0.0017 17.4 6.0 0.005 15.9 6.0 1.8 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 TACC_C PF05010.14 ORX53134.1 - 0.0018 18.1 9.2 0.076 12.8 0.1 2.6 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TFIIA PF03153.13 ORX53134.1 - 0.13 12.2 17.6 0.15 12.1 17.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1664 PF07889.12 ORX53134.1 - 0.24 11.4 5.7 0.49 10.4 4.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 ORX53134.1 - 0.51 8.9 3.2 0.92 8.0 3.2 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 ORX53134.1 - 1.5 8.1 9.8 0.99 8.7 6.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) AAA_23 PF13476.6 ORX53134.1 - 7.9 6.9 9.8 1.5 9.3 5.5 2.0 2 0 0 2 2 2 0 AAA domain PAP2 PF01569.21 ORX53135.1 - 7.7e-20 71.0 5.2 7.7e-20 71.0 5.2 2.0 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ORX53135.1 - 0.0052 16.5 9.2 0.021 14.5 9.2 2.2 1 1 0 1 1 1 1 PAP2 superfamily Fer4_5 PF12801.7 ORX53135.1 - 0.035 14.1 2.0 0.035 14.1 2.0 3.5 4 0 0 4 4 4 0 4Fe-4S binding domain Yuri_gagarin PF15934.5 ORX53136.1 - 0.013 15.4 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 Yuri gagarin PorP_SprF PF11751.8 ORX53137.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.6 1 1 0 1 1 1 0 Type IX secretion system membrane protein PorP/SprF UDPG_MGDP_dh_N PF03721.14 ORX53138.1 - 3.3e-63 212.6 0.4 6.5e-63 211.7 0.1 1.6 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ORX53138.1 - 8.6e-35 119.3 0.4 8.8e-34 116.1 0.3 2.5 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ORX53138.1 - 2.4e-29 101.4 0.0 4.7e-29 100.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 ORX53138.1 - 0.005 17.0 0.0 0.59 10.3 0.0 3.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase UvdE PF03851.14 ORX53138.1 - 0.18 11.0 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 UV-endonuclease UvdE MBF1 PF08523.10 ORX53140.1 - 1e-21 77.2 4.3 1e-21 77.2 4.3 1.8 2 1 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 ORX53140.1 - 1.1e-13 51.0 0.3 1.9e-13 50.3 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ORX53140.1 - 2.7e-05 24.4 0.0 6.3e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ORX53140.1 - 0.003 17.6 0.1 0.0057 16.6 0.1 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain RrnaAD PF00398.20 ORX53140.1 - 0.0079 15.3 0.0 0.01 14.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase VSG_B PF13206.6 ORX53140.1 - 0.046 13.0 1.3 0.053 12.8 1.3 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain zf-LITAF-like PF10601.9 ORX53141.1 - 0.005 17.1 0.0 0.009 16.3 0.0 1.4 1 0 0 1 1 1 1 LITAF-like zinc ribbon domain DUF908 PF06012.12 ORX53142.1 - 0.038 13.4 2.5 0.058 12.8 2.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) SMN PF06003.12 ORX53142.1 - 0.31 10.3 6.6 0.56 9.4 6.6 1.4 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) SR-25 PF10500.9 ORX53142.1 - 1.2 8.7 32.4 0.43 10.1 28.8 1.8 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein YqfQ PF14181.6 ORX53142.1 - 1.5 9.0 6.4 3 8.0 6.4 1.4 1 0 0 1 1 1 0 YqfQ-like protein Med19 PF10278.9 ORX53142.1 - 2.4 8.1 25.1 0.38 10.7 21.1 1.6 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Ferlin_C PF16165.5 ORX53142.1 - 2.5 8.0 8.2 0.71 9.8 4.6 1.8 2 0 0 2 2 2 0 Ferlin C-terminus Dsh_C PF12316.8 ORX53142.1 - 2.8 8.3 7.3 0.88 9.9 4.0 1.7 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Connexin PF00029.19 ORX53142.1 - 2.9 7.6 9.5 0.27 11.0 5.2 1.5 2 0 0 2 2 2 0 Connexin DUF4614 PF15391.6 ORX53142.1 - 3.1 7.8 12.5 0.44 10.5 8.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) BCS1_N PF08740.11 ORX53143.1 - 7.2e-18 65.2 0.0 1.4e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ORX53143.1 - 1.2e-11 45.1 0.0 4.7e-11 43.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX53143.1 - 3.6e-07 30.2 0.0 8.9e-07 29.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX53143.1 - 9.6e-06 25.4 0.1 3.9e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ORX53143.1 - 0.00029 21.0 0.0 0.00086 19.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_6 PF12774.7 ORX53143.1 - 0.00037 19.6 0.0 0.00065 18.8 0.0 1.3 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_16 PF13191.6 ORX53143.1 - 0.00065 20.1 0.1 0.002 18.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ORX53143.1 - 0.0017 18.2 0.6 0.0033 17.3 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 ORX53143.1 - 0.0025 18.4 0.1 0.012 16.1 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX53143.1 - 0.0025 17.3 0.0 0.0059 16.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 ORX53143.1 - 0.0049 17.2 0.0 0.022 15.2 0.0 2.1 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 ORX53143.1 - 0.0074 15.5 0.0 0.019 14.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ORX53143.1 - 0.0092 16.3 0.0 0.033 14.5 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ORX53143.1 - 0.031 14.1 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ORX53143.1 - 0.031 13.6 0.0 0.061 12.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PPV_E1_C PF00519.17 ORX53143.1 - 0.044 12.6 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase AAA_25 PF13481.6 ORX53143.1 - 0.063 12.9 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX53143.1 - 0.064 13.2 0.4 0.42 10.5 0.1 2.5 2 1 1 3 3 3 0 NACHT domain AAA_28 PF13521.6 ORX53143.1 - 0.093 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX53143.1 - 0.098 12.4 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX53143.1 - 0.099 13.0 0.0 0.31 11.4 0.0 1.9 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ORX53143.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE APG9 PF04109.16 ORX53145.1 - 6.9e-204 678.3 11.3 8e-204 678.1 11.3 1.0 1 0 0 1 1 1 1 Autophagy protein Apg9 Sel1 PF08238.12 ORX53146.1 - 1.3e-16 60.7 9.8 7.7e-07 29.6 1.5 3.8 4 0 0 4 4 4 3 Sel1 repeat TPR_11 PF13414.6 ORX53146.1 - 0.064 12.9 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 0 TPR repeat p450 PF00067.22 ORX53147.1 - 3.2e-33 115.2 1.6 2.4e-31 109.0 1.6 2.1 1 1 0 1 1 1 1 Cytochrome P450 DUF410 PF04190.13 ORX53147.1 - 0.026 14.3 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF410) CT_C_D PF02682.16 ORX53147.1 - 0.15 11.8 1.2 0.34 10.6 0.5 1.8 1 1 1 2 2 2 0 Carboxyltransferase domain, subdomain C and D Thymidylat_synt PF00303.19 ORX53148.1 - 1.6e-113 378.3 0.0 1.8e-113 378.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate synthase Csm1 PF12539.8 ORX53149.1 - 1.4e-08 35.3 0.0 2.6e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 Tropomyosin_1 PF12718.7 ORX53149.1 - 6.6e-06 26.3 18.5 0.002 18.3 7.9 2.3 1 1 1 2 2 2 2 Tropomyosin like DUF5094 PF17015.5 ORX53149.1 - 0.0013 18.9 2.5 0.0024 18.0 0.1 2.2 1 1 0 2 2 2 1 Domain of unknown function (DUF5094) Leu_zip PF15294.6 ORX53149.1 - 0.012 15.2 11.4 0.017 14.6 11.1 1.4 1 1 0 1 1 1 0 Leucine zipper DUF4559 PF15112.6 ORX53149.1 - 0.032 13.9 7.5 0.012 15.3 5.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4559) DUF2935 PF11155.8 ORX53149.1 - 0.036 14.4 1.3 0.074 13.4 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) DUF2746 PF10874.8 ORX53149.1 - 0.047 14.1 0.0 0.084 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) MscS_porin PF12795.7 ORX53149.1 - 0.087 12.4 15.5 0.014 14.9 9.7 2.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Spc7 PF08317.11 ORX53149.1 - 0.091 11.6 14.9 0.19 10.6 15.0 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein TMPIT PF07851.13 ORX53149.1 - 0.26 10.5 9.8 0.022 14.0 2.2 1.9 1 1 1 2 2 2 0 TMPIT-like protein HMMR_N PF15905.5 ORX53149.1 - 0.32 10.4 18.9 0.28 10.6 7.2 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Csm1_N PF18504.1 ORX53149.1 - 0.34 11.3 16.0 6.8 7.1 3.5 4.4 3 1 1 4 4 4 0 Csm1 N-terminal domain KxDL PF10241.9 ORX53149.1 - 0.4 11.0 12.1 4.3 7.7 0.1 3.7 2 1 2 4 4 4 0 Uncharacterized conserved protein LMBR1 PF04791.16 ORX53149.1 - 0.4 9.5 3.3 0.56 9.1 3.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 ORX53149.1 - 0.4 10.2 8.9 0.59 9.6 8.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 ORX53149.1 - 0.69 10.1 9.7 0.26 11.4 5.1 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 ORX53149.1 - 1.2 9.2 8.4 0.37 10.8 1.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 ORX53149.1 - 1.4 9.0 17.9 0.88 9.6 12.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Med9 PF07544.13 ORX53149.1 - 1.8 8.7 8.8 4.4 7.5 2.7 3.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4407 PF14362.6 ORX53149.1 - 2 7.7 11.8 6.2 6.1 11.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 ORX53149.1 - 2.3 8.6 15.9 0.24 11.7 3.9 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_1 PF00170.21 ORX53149.1 - 4.9 7.3 15.3 0.34 11.1 2.1 2.9 3 0 0 3 3 3 0 bZIP transcription factor DUF16 PF01519.16 ORX53149.1 - 5.6 7.5 10.2 10 6.6 0.4 2.7 1 1 2 3 3 3 0 Protein of unknown function DUF16 BLOC1_2 PF10046.9 ORX53149.1 - 6.1 7.2 10.1 1.7 9.0 1.7 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DHR10 PF18595.1 ORX53149.1 - 9.1 6.4 23.5 24 5.0 0.2 3.3 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain Cyclin_N PF00134.23 ORX53152.1 - 9.5e-11 41.5 0.2 1.1e-10 41.3 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX53152.1 - 2.2e-08 34.7 0.0 2.6e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Cyclin RII_binding_1 PF10522.9 ORX53152.1 - 0.034 14.3 0.1 0.07 13.4 0.1 1.5 1 0 0 1 1 1 0 RII binding domain Thioredoxin PF00085.20 ORX53154.1 - 5.9e-33 112.9 0.2 6.7e-33 112.8 0.2 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX53154.1 - 6.6e-08 33.0 0.2 5.7e-07 30.0 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ORX53154.1 - 2.7e-06 27.3 0.1 2.7e-06 27.3 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family OST3_OST6 PF04756.13 ORX53154.1 - 7.7e-06 25.5 0.1 8.2e-06 25.4 0.1 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ORX53154.1 - 1.5e-05 25.2 0.1 3.6e-05 24.0 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ORX53154.1 - 8.3e-05 22.7 0.1 0.00011 22.3 0.1 1.2 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 ORX53154.1 - 0.00094 18.9 0.1 0.0025 17.6 0.1 1.6 1 1 1 2 2 2 1 Redoxin Thioredoxin_9 PF14595.6 ORX53154.1 - 0.0017 18.1 0.0 0.0018 18.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 ORX53154.1 - 0.005 16.8 0.0 0.0071 16.3 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 ORX53154.1 - 0.013 15.7 0.0 0.022 15.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin TraF PF13728.6 ORX53154.1 - 0.033 14.0 0.0 0.04 13.7 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_5 PF13743.6 ORX53154.1 - 0.09 12.4 0.1 0.25 11.0 0.0 1.6 1 1 1 2 2 2 0 Thioredoxin DPPIV_N PF00930.21 ORX53155.1 - 7.8e-91 304.5 5.7 2e-90 303.1 2.4 2.7 3 0 0 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ORX53155.1 - 1.3e-51 175.1 2.2 2.4e-51 174.2 2.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ORX53155.1 - 0.00019 22.1 0.1 0.0024 18.5 0.0 2.5 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX53155.1 - 0.00061 19.1 0.5 0.074 12.3 0.0 2.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ORX53155.1 - 0.0014 18.3 0.6 0.05 13.2 0.2 2.6 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) PD40 PF07676.12 ORX53155.1 - 0.0014 18.5 0.3 0.79 9.7 0.0 3.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat BAAT_C PF08840.11 ORX53155.1 - 0.0065 16.4 0.0 0.065 13.1 0.0 2.2 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal JmjC PF02373.22 ORX53156.1 - 7e-16 58.7 0.0 1.5e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ORX53156.1 - 0.00092 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Cupin-like domain DUF3927 PF13064.6 ORX53157.1 - 0.58 10.2 0.0 0.58 10.2 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3927) Kei1 PF08552.11 ORX53157.1 - 6.7 6.5 12.4 1.4e+02 2.3 12.4 2.3 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 zf-Tim10_DDP PF02953.15 ORX53158.1 - 2.7e-15 55.8 0.5 3.6e-15 55.4 0.5 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Cyclin PF08613.11 ORX53159.1 - 2e-32 112.8 0.1 3.4e-32 112.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX53159.1 - 4.4e-06 26.5 0.5 7.1e-06 25.8 0.5 1.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain SAP30_Sin3_bdg PF13867.6 ORX53160.1 - 9.2e-17 61.1 0.3 1.1e-16 60.8 0.3 1.1 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 zf-RING_2 PF13639.6 ORX53161.1 - 1.3e-09 38.2 11.6 2.3e-09 37.4 11.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX53161.1 - 1.2e-08 34.6 11.1 2.1e-08 33.8 11.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX53161.1 - 3.3e-08 33.3 10.8 5.5e-08 32.5 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX53161.1 - 6.5e-07 29.1 6.9 9.8e-07 28.5 6.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX53161.1 - 1.1e-05 25.3 5.5 1.1e-05 25.3 5.5 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX53161.1 - 5.9e-05 23.3 10.9 0.00017 21.8 10.9 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX53161.1 - 0.00051 19.9 10.5 0.00081 19.3 10.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_10 PF16685.5 ORX53161.1 - 0.0012 18.9 4.0 0.0026 17.8 4.0 1.6 1 0 0 1 1 1 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 ORX53161.1 - 0.011 15.6 8.3 0.02 14.7 8.3 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Baculo_IE-1 PF05290.11 ORX53161.1 - 0.034 14.1 5.1 0.059 13.3 5.1 1.3 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) TetR_C_3 PF08362.11 ORX53161.1 - 0.1 12.5 0.1 18 5.3 0.0 2.3 2 0 0 2 2 2 0 YcdC-like protein, C-terminal region zf-P11 PF03854.14 ORX53161.1 - 0.18 11.5 5.8 0.3 10.8 5.8 1.3 1 0 0 1 1 1 0 P-11 zinc finger zf-RING_4 PF14570.6 ORX53161.1 - 0.73 9.7 8.1 1.4 8.8 8.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ORX53161.1 - 1 9.5 11.0 2.4 8.4 11.0 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ORX53161.1 - 2.1 8.1 9.1 4.3 7.2 9.1 1.5 1 0 0 1 1 1 0 RING-like zinc finger zf-ANAPC11 PF12861.7 ORX53161.1 - 2.7 8.1 7.2 10 6.3 7.2 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Arrestin_C PF02752.22 ORX53162.1 - 1.7e-14 54.4 0.0 1e-12 48.6 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain DUF1892 PF08987.10 ORX53162.1 - 0.055 13.7 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1892) Arrestin_N PF00339.29 ORX53162.1 - 0.068 13.2 0.0 15 5.7 0.0 2.3 1 1 1 2 2 2 0 Arrestin (or S-antigen), N-terminal domain UPF0014 PF03649.13 ORX53163.1 - 8.2e-59 198.9 19.8 1.1e-58 198.5 19.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) TFR_dimer PF04253.15 ORX53164.1 - 5.3e-29 100.8 0.2 9.7e-29 99.9 0.2 1.4 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX53164.1 - 3e-22 79.3 0.0 6.5e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX53164.1 - 2.7e-08 33.7 0.0 9.1e-08 32.0 0.0 1.9 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 ORX53164.1 - 0.0055 16.4 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Pkinase PF00069.25 ORX53165.1 - 3.5e-18 65.9 0.0 2.1e-17 63.4 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ORX53165.1 - 3.1e-07 29.5 1.4 6.4e-07 28.5 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Polysacc_deac_1 PF01522.21 ORX53166.1 - 2.5e-28 98.5 0.3 3.9e-28 97.8 0.3 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ORX53166.1 - 4.5e-09 36.0 0.1 7.7e-09 35.2 0.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 57 Pkinase PF00069.25 ORX53168.1 - 2.2e-50 171.5 0.0 3.5e-50 170.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53168.1 - 7e-19 68.1 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX53168.1 - 0.00031 20.7 0.6 0.0012 18.8 0.6 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX53168.1 - 0.00048 19.5 0.0 0.001 18.4 0.0 1.5 1 1 0 1 1 1 1 Kinase-like PAS_9 PF13426.7 ORX53168.1 - 0.00049 20.3 0.0 4.2 7.7 0.0 3.4 3 0 0 3 3 3 2 PAS domain Kdo PF06293.14 ORX53168.1 - 0.00061 19.2 0.5 0.0013 18.1 0.5 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX53168.1 - 0.00095 18.8 0.2 0.0018 17.9 0.2 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX53168.1 - 0.0038 16.1 0.0 0.0038 16.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX53168.1 - 0.0098 14.9 0.1 0.0098 14.9 0.1 1.6 2 0 0 2 2 1 1 Haspin like kinase domain PAS_8 PF13188.7 ORX53168.1 - 0.01 15.9 0.2 7.4 6.7 0.0 3.3 4 0 0 4 4 4 0 PAS domain PAS PF00989.25 ORX53168.1 - 0.035 14.1 0.0 1.1 9.2 0.0 2.6 2 0 0 2 2 2 0 PAS fold CaMBD PF02888.16 ORX53168.1 - 0.14 12.3 0.1 0.45 10.7 0.1 1.8 1 0 0 1 1 1 0 Calmodulin binding domain ING PF12998.7 ORX53172.1 - 0.18 12.4 1.0 0.41 11.3 0.0 2.0 3 0 0 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding QueF_N PF14819.6 ORX53174.1 - 0.033 14.5 0.1 0.057 13.7 0.1 1.3 1 0 0 1 1 1 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term SPC12 PF06645.13 ORX53174.1 - 9.8 6.3 8.3 0.31 11.1 0.3 2.5 3 0 0 3 3 3 0 Microsomal signal peptidase 12 kDa subunit (SPC12) IF-2B PF01008.17 ORX53175.1 - 0.0048 16.2 2.7 0.0061 15.8 2.7 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF2031 PF09592.10 ORX53175.1 - 0.2 11.2 11.0 0.28 10.7 10.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2031) TraI_2_C PF07515.11 ORX53175.1 - 0.27 11.2 7.5 5.8 6.9 0.2 2.8 2 1 1 3 3 3 0 Putative conjugal transfer nickase/helicase TraI C-term NBP1 PF08537.10 ORX53175.1 - 1.3 8.4 13.6 1.2 8.5 12.4 1.5 1 1 0 1 1 1 0 Fungal Nap binding protein NBP1 NicO PF03824.16 ORX53176.1 - 3.1e-67 226.9 13.9 3.9e-67 226.6 13.9 1.0 1 0 0 1 1 1 1 High-affinity nickel-transport protein MHYT PF03707.16 ORX53176.1 - 0.036 14.2 0.4 0.036 14.2 0.4 4.0 4 0 0 4 4 4 0 Bacterial signalling protein N terminal repeat Phage_Coat_B PF05356.11 ORX53176.1 - 5.5 7.0 9.0 1.4 8.9 1.9 2.6 3 0 0 3 3 3 0 Phage Coat protein B NicO PF03824.16 ORX53179.1 - 7.6e-79 265.0 16.3 8.8e-79 264.8 16.3 1.0 1 0 0 1 1 1 1 High-affinity nickel-transport protein MHYT PF03707.16 ORX53179.1 - 0.058 13.6 0.6 0.058 13.6 0.6 4.1 5 0 0 5 5 5 0 Bacterial signalling protein N terminal repeat UCR_UQCRX_QCR9 PF05365.12 ORX53179.1 - 3.8 7.5 8.2 0.37 10.8 0.8 2.8 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Phage_Coat_B PF05356.11 ORX53179.1 - 8.5 6.4 9.0 1.7 8.6 1.9 2.6 3 0 0 3 3 3 0 Phage Coat protein B HLH PF00010.26 ORX53180.1 - 7.2e-13 48.3 0.4 1.2e-12 47.6 0.4 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SLX9 PF15341.6 ORX53180.1 - 0.042 14.2 0.9 0.056 13.8 0.9 1.2 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 Ribosomal_L16 PF00252.18 ORX53181.1 - 9.5e-47 158.3 0.6 1.1e-46 158.1 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF1899 PF08953.11 ORX53182.1 - 4.4e-32 109.8 0.0 8.1e-32 108.9 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 ORX53182.1 - 6.2e-22 77.5 2.9 3.8e-05 24.4 0.1 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_4 PF16300.5 ORX53182.1 - 3e-21 75.0 1.0 6.9e-21 73.9 1.0 1.6 1 0 0 1 1 1 1 Type of WD40 repeat ANAPC4_WD40 PF12894.7 ORX53182.1 - 1.8e-09 37.8 0.0 0.00013 22.2 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX53182.1 - 0.0012 18.8 0.2 0.02 14.8 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX53182.1 - 0.0096 14.6 0.2 0.38 9.3 0.1 2.4 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX53182.1 - 0.066 11.9 0.1 0.11 11.2 0.1 1.3 1 0 0 1 1 1 0 Nup133 N terminal like Ge1_WD40 PF16529.5 ORX53182.1 - 0.096 11.6 0.0 9.7 5.0 0.0 2.6 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Fib_alpha PF08702.10 ORX53182.1 - 0.33 11.1 2.4 0.55 10.4 2.4 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 ORX53182.1 - 1.7 8.7 7.2 1.5 8.9 5.1 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus U-box PF04564.15 ORX53183.1 - 2e-23 82.3 0.1 3.7e-23 81.5 0.1 1.5 1 0 0 1 1 1 1 U-box domain TPR_11 PF13414.6 ORX53183.1 - 5.6e-10 38.8 2.3 0.00065 19.3 0.0 3.1 1 1 2 3 3 3 2 TPR repeat TPR_2 PF07719.17 ORX53183.1 - 1.4e-09 37.3 7.6 0.034 14.3 1.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53183.1 - 4.1e-09 35.9 8.0 0.00018 21.2 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53183.1 - 1.9e-07 31.6 0.8 0.02 15.6 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 ORX53183.1 - 7.6e-07 29.8 8.6 7.6e-07 29.8 8.6 2.1 2 1 1 3 3 1 1 CHIP N-terminal tetratricopeptide repeat domain ANAPC3 PF12895.7 ORX53183.1 - 5.1e-06 26.6 3.9 7.4e-06 26.1 3.3 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ORX53183.1 - 4.1e-05 23.4 9.2 0.01 16.0 0.2 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat zf-NOSIP PF15906.5 ORX53183.1 - 0.00075 19.6 0.0 0.0029 17.7 0.0 2.0 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein TPR_17 PF13431.6 ORX53183.1 - 0.00087 19.5 0.2 0.088 13.2 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX53183.1 - 0.0012 19.1 5.6 0.39 11.0 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF4838 PF16126.5 ORX53183.1 - 0.0048 16.3 0.1 0.0082 15.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) PA28_beta PF02252.18 ORX53183.1 - 0.047 13.4 1.5 0.09 12.4 1.5 1.5 1 0 0 1 1 1 0 Proteasome activator pa28 beta subunit TPR_14 PF13428.6 ORX53183.1 - 0.09 13.6 3.0 1.1 10.3 0.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX53183.1 - 0.32 11.7 2.2 6.2 7.7 0.7 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat V-ATPase_G PF03179.15 ORX53183.1 - 1.7 9.2 8.4 0.33 11.5 3.5 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit ENTH PF01417.20 ORX53184.1 - 1.5e-47 160.7 0.1 2.5e-47 160.0 0.1 1.4 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ORX53184.1 - 1.7e-07 30.5 0.1 2.4e-07 30.1 0.1 1.3 1 0 0 1 1 1 1 ANTH domain TAF4 PF05236.14 ORX53184.1 - 0.019 14.8 5.7 0.037 13.8 5.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family FANCM-MHF_bd PF16783.5 ORX53184.1 - 0.14 12.3 0.9 11 6.1 0.0 2.4 2 0 0 2 2 2 0 FANCM to MHF binding domain UIM PF02809.20 ORX53184.1 - 8.2 6.6 9.5 9.5 6.4 0.4 3.1 3 0 0 3 3 3 0 Ubiquitin interaction motif CBM_21 PF03370.13 ORX53185.1 - 1.9e-21 76.3 0.0 4e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 ORX53185.1 - 4.7e-09 36.7 1.4 6.7e-07 29.8 1.4 2.6 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) V_ATPase_I PF01496.19 ORX53186.1 - 0 1050.9 0.0 0 1050.7 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Angiomotin_C PF12240.8 ORX53186.1 - 0.0075 15.8 1.1 0.0075 15.8 1.1 1.7 2 0 0 2 2 2 1 Angiomotin C terminal Ribosomal_L19e PF01280.20 ORX53189.1 - 8.6e-63 210.7 10.0 8.6e-63 210.7 10.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e Lant_dehydr_C PF14028.6 ORX53189.1 - 0.0013 18.3 0.2 0.0022 17.6 0.2 1.3 1 0 0 1 1 1 1 Lantibiotic biosynthesis dehydratase C-term PTPS PF01242.19 ORX53190.1 - 3.7e-33 114.1 0.4 4.2e-33 113.9 0.4 1.0 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase Hydrolase_4 PF12146.8 ORX53191.1 - 9.5e-10 38.1 0.1 1.9e-06 27.4 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX53191.1 - 3.5e-07 31.1 0.2 0.0005 20.7 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ORX53191.1 - 3e-06 27.0 2.2 0.00048 19.8 0.2 2.1 1 1 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ORX53191.1 - 3.5e-06 26.7 0.4 0.00018 21.1 0.0 2.2 1 1 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ORX53191.1 - 3.9e-06 26.7 1.1 0.00017 21.3 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold CBS PF00571.28 ORX53192.1 - 5.3e-18 65.2 3.5 8.6e-09 35.7 0.0 4.7 5 0 0 5 5 5 4 CBS domain DDE_3 PF13358.6 ORX53194.1 - 0.00099 18.9 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DDE_3 PF13358.6 ORX53195.1 - 0.0054 16.5 0.0 0.0068 16.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF3102 PF11300.8 ORX53195.1 - 0.019 15.2 0.0 0.022 15.0 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) ATP12 PF07542.11 ORX53196.1 - 9.2e-41 138.9 0.3 1.7e-40 138.0 0.3 1.5 1 0 0 1 1 1 1 ATP12 chaperone protein DUF438 PF04282.13 ORX53196.1 - 0.089 12.8 0.3 0.4 10.7 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF438) Sugar_tr PF00083.24 ORX53197.1 - 4.2e-110 368.7 25.7 9.5e-110 367.5 25.7 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX53197.1 - 1.6e-28 99.7 56.8 6.3e-25 87.8 26.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX53197.1 - 0.00027 19.4 14.1 0.0064 14.8 2.5 4.0 3 1 1 4 4 4 2 Organic Anion Transporter Polypeptide (OATP) family UPF0182 PF03699.13 ORX53197.1 - 0.15 10.2 4.1 0.24 9.5 4.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Sugar_tr PF00083.24 ORX53198.1 - 1.8e-77 261.1 36.0 1e-53 182.9 21.0 2.9 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX53198.1 - 1.6e-19 70.1 33.1 5.4e-10 38.7 5.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX53198.1 - 0.025 12.9 4.5 0.012 13.9 1.3 2.1 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Bromodomain PF00439.25 ORX53201.1 - 3.5e-22 78.3 0.2 6.4e-22 77.4 0.2 1.5 1 0 0 1 1 1 1 Bromodomain YL1 PF05764.13 ORX53201.1 - 0.17 12.0 19.9 0.025 14.7 13.9 2.1 2 0 0 2 2 2 0 YL1 nuclear protein Lin-8 PF03353.15 ORX53201.1 - 0.3 10.6 6.0 0.56 9.7 6.0 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 ORX53201.1 - 0.5 8.6 15.3 0.84 7.9 13.4 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF4614 PF15391.6 ORX53201.1 - 8.8 6.3 15.7 1.5 8.7 9.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Neur_chan_memb PF02932.16 ORX53201.1 - 9.9 6.1 10.3 1.7 8.6 5.9 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_S13_N PF08069.12 ORX53202.1 - 1.2e-31 108.5 0.7 2.1e-31 107.7 0.2 1.6 2 0 0 2 2 2 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 ORX53202.1 - 1.5e-13 50.7 0.4 2e-13 50.3 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein S15 DUF4423 PF14394.6 ORX53203.1 - 0.02 14.6 0.5 0.049 13.3 0.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) MAS20 PF02064.15 ORX53204.1 - 1.5e-43 148.0 0.4 1.5e-43 148.0 0.4 1.9 2 0 0 2 2 2 1 MAS20 protein import receptor zf-MYND PF01753.18 ORX53204.1 - 1e-06 28.7 13.6 1.7e-06 28.0 13.6 1.4 1 0 0 1 1 1 1 MYND finger SET PF00856.28 ORX53204.1 - 0.0001 22.7 0.1 0.0011 19.4 0.0 2.5 2 1 0 2 2 2 1 SET domain Rhodanese_C PF12368.8 ORX53204.1 - 0.045 14.1 7.4 0.1 13.0 7.4 1.5 1 0 0 1 1 1 0 Rhodanase C-terminal PcfJ PF14284.6 ORX53204.1 - 0.66 9.9 6.6 1.1 9.1 0.8 2.6 2 0 0 2 2 2 0 PcfJ-like protein Adaptin_N PF01602.20 ORX53206.1 - 9.7e-115 384.1 7.2 1.2e-114 383.7 7.2 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 ORX53206.1 - 2.4e-58 196.6 0.3 5.8e-58 195.3 0.3 1.7 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ORX53206.1 - 9.9e-32 109.5 0.0 3.1e-31 107.9 0.0 1.9 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 ORX53206.1 - 1.3e-20 73.5 2.3 8.5e-10 38.9 0.0 5.9 4 1 2 6 6 6 4 HEAT repeats Cnd1 PF12717.7 ORX53206.1 - 1.1e-12 48.3 8.4 0.00093 19.3 0.0 4.6 4 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 ORX53206.1 - 0.0059 17.2 2.5 6.1 7.8 0.0 4.8 5 0 0 5 5 5 1 PBS lyase HEAT-like repeat HEAT PF02985.22 ORX53206.1 - 0.061 13.6 13.8 17 6.0 0.2 7.3 8 1 1 9 9 9 0 HEAT repeat HEAT_EZ PF13513.6 ORX53206.1 - 0.17 12.4 2.7 2.4 8.7 0.3 3.6 3 0 0 3 3 3 0 HEAT-like repeat RTP1_C1 PF10363.9 ORX53206.1 - 1.6 9.0 4.3 10 6.3 0.0 3.7 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 SRA1 PF07304.11 ORX53207.1 - 2.2e-12 47.0 0.4 2.7e-12 46.7 0.4 1.2 1 1 0 1 1 1 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.15 ORX53207.1 - 1.6e-07 31.5 0.1 1.1e-05 25.5 0.1 2.1 1 1 1 2 2 2 2 Prp18 domain TRM PF02005.16 ORX53207.1 - 0.17 11.0 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Mito_carr PF00153.27 ORX53208.1 - 6.3e-68 224.8 2.5 3.8e-24 84.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX53208.1 - 4.4e-05 22.8 0.1 0.028 13.6 0.0 2.2 2 0 0 2 2 2 2 Gammaproteobacterial serine protease Pirin_C PF05726.13 ORX53209.1 - 5.6e-31 107.0 0.0 3.9e-30 104.3 0.0 2.2 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Pirin PF02678.16 ORX53209.1 - 7e-31 106.4 0.1 1.2e-30 105.6 0.1 1.4 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.11 ORX53209.1 - 0.071 12.8 1.6 0.12 12.1 0.6 1.9 2 0 0 2 2 2 0 Cupin domain Oxidored_FMN PF00724.20 ORX53210.1 - 1.5e-64 218.4 0.0 1.9e-64 218.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Efg1 PF10153.9 ORX53211.1 - 9.9e-21 74.2 1.7 9.9e-21 74.2 1.7 1.8 2 0 0 2 2 2 1 rRNA-processing protein Efg1 REC1 PF18501.1 ORX53211.1 - 0.0011 19.0 7.2 0.0044 17.0 2.1 2.0 2 0 0 2 2 2 2 Alpha helical recognition lobe domain Lipase_3 PF01764.25 ORX53212.1 - 3.7e-07 30.1 0.0 1.1e-06 28.5 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ORX53212.1 - 0.0033 18.1 0.4 0.012 16.2 0.0 1.9 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX53212.1 - 0.0084 15.4 0.0 0.012 14.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 UPF0227 PF05728.12 ORX53212.1 - 0.013 15.5 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF2974 PF11187.8 ORX53212.1 - 0.051 13.1 0.1 0.14 11.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 ORX53212.1 - 0.094 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein RabGAP-TBC PF00566.18 ORX53213.1 - 3.4e-54 183.8 0.1 3.4e-54 183.8 0.1 2.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain MAD PF05557.13 ORX53213.1 - 0.013 14.0 19.8 0.019 13.4 19.8 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein CdvA PF18822.1 ORX53213.1 - 0.02 14.7 1.2 0.02 14.7 1.2 3.9 2 1 2 4 4 4 0 CdvA-like coiled-coil domain HALZ PF02183.18 ORX53213.1 - 0.02 15.1 8.2 3 8.1 0.3 4.0 3 0 0 3 3 3 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 ORX53213.1 - 0.17 12.1 28.4 0.37 11.0 17.9 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3450 PF11932.8 ORX53213.1 - 0.45 9.8 30.2 0.25 10.6 15.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) KIP1 PF07765.12 ORX53213.1 - 0.48 10.6 7.5 0.27 11.4 4.2 2.3 2 0 0 2 2 2 0 KIP1-like protein BLOC1_2 PF10046.9 ORX53213.1 - 0.82 10.0 16.7 0.14 12.4 3.9 2.8 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 bZIP_1 PF00170.21 ORX53213.1 - 0.84 9.8 14.8 0.75 9.9 1.5 3.9 3 1 1 4 4 4 0 bZIP transcription factor bZIP_2 PF07716.15 ORX53213.1 - 1.2 9.3 13.6 3.8 7.6 1.6 3.7 2 1 1 3 3 3 0 Basic region leucine zipper FUSC PF04632.12 ORX53213.1 - 2.6 6.4 11.4 5.1 5.5 11.4 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1664 PF07889.12 ORX53213.1 - 4.6 7.3 11.9 0.46 10.5 3.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ORX53213.1 - 5.5 7.2 29.3 36 4.5 5.6 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DNA_primase_lrg PF04104.14 ORX53214.1 - 1.3e-83 280.5 0.2 3.4e-83 279.1 0.0 1.7 2 0 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit GATase_4 PF13230.6 ORX53215.1 - 2.3e-19 69.4 0.1 3.5e-18 65.5 0.1 2.0 1 1 0 1 1 1 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 ORX53215.1 - 1.1e-09 38.6 0.0 1.8e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Anp1 PF03452.14 ORX53216.1 - 1.4e-79 267.2 0.1 1.8e-79 266.9 0.1 1.1 1 0 0 1 1 1 1 Anp1 Glyco_tranf_2_4 PF13704.6 ORX53216.1 - 0.00086 19.8 0.4 0.002 18.6 0.4 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 SNAP PF14938.6 ORX53217.1 - 1e-27 97.3 10.1 1.4e-27 96.9 10.1 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DHR-2 PF06920.13 ORX53217.1 - 0.0072 15.0 0.3 0.031 12.9 0.4 1.8 1 1 0 1 1 1 1 Dock homology region 2 PRTase_2 PF15609.6 ORX53217.1 - 0.1 12.1 0.1 0.17 11.4 0.1 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase S4 PF01479.25 ORX53220.1 - 4.8e-16 58.2 0.1 1.1e-15 57.1 0.1 1.6 2 0 0 2 2 2 1 S4 domain S4_2 PF13275.6 ORX53220.1 - 0.00039 20.2 0.0 0.00067 19.4 0.0 1.3 1 0 0 1 1 1 1 S4 domain Ub-Mut7C PF14451.6 ORX53220.1 - 0.1 12.5 0.1 0.35 10.8 0.0 1.8 2 0 0 2 2 2 0 Mut7-C ubiquitin S1FA PF04689.13 ORX53220.1 - 0.22 11.7 1.4 4.3 7.6 0.3 2.4 2 0 0 2 2 2 0 DNA binding protein S1FA Abhydrolase_3 PF07859.13 ORX53221.1 - 4.5e-11 43.0 0.0 5.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold PQ-loop PF04193.14 ORX53222.1 - 3.2e-28 97.3 13.2 2.5e-14 52.8 0.3 2.8 3 0 0 3 3 3 2 PQ loop repeat 7TM_GPCR_Srh PF10318.9 ORX53222.1 - 0.011 14.8 2.0 0.021 13.8 0.7 2.1 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srh DUF389 PF04087.14 ORX53222.1 - 0.018 15.1 0.1 0.1 12.7 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF389) Pkinase PF00069.25 ORX53223.1 - 7.1e-51 173.1 0.8 1.3e-50 172.3 0.8 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53223.1 - 4e-24 85.3 0.4 6.5e-24 84.6 0.1 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX53223.1 - 0.0011 17.8 0.3 0.0015 17.3 0.3 1.3 1 0 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ORX53223.1 - 0.0024 17.5 0.6 0.31 10.6 0.6 2.3 1 1 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 ORX53223.1 - 0.0026 16.8 0.1 0.0041 16.1 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase CDC45 PF02724.14 ORX53224.1 - 3.6 5.8 16.5 5.4 5.2 16.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 ORX53224.1 - 4 6.1 10.0 2.3 6.9 8.5 1.3 1 1 0 1 1 1 0 Raftlin F-box-like PF12937.7 ORX53225.1 - 7.7e-07 28.9 0.4 1.9e-06 27.7 0.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX53225.1 - 6.2e-05 22.8 0.2 0.00013 21.8 0.2 1.5 1 0 0 1 1 1 1 F-box domain TPR_2 PF07719.17 ORX53225.1 - 0.026 14.6 0.0 0.046 13.9 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX53225.1 - 0.18 12.1 0.0 0.33 11.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ABC_membrane_2 PF06472.15 ORX53226.1 - 1.4e-97 326.4 3.8 1.9e-97 325.9 3.8 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX53226.1 - 1.1e-17 64.8 0.0 2.3e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX53226.1 - 3.5e-05 23.7 0.1 0.00026 20.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX53226.1 - 0.00028 21.5 0.1 0.0087 16.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ORX53226.1 - 0.0086 15.5 0.0 0.12 11.8 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain SbmA_BacA PF05992.12 ORX53226.1 - 0.011 15.2 0.9 0.018 14.5 0.9 1.3 1 0 0 1 1 1 0 SbmA/BacA-like family AAA_29 PF13555.6 ORX53226.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Rad17 PF03215.15 ORX53226.1 - 0.065 13.1 0.7 0.27 11.1 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain WD40 PF00400.32 ORX53227.1 - 1.3e-45 152.4 20.8 2.7e-06 28.0 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX53227.1 - 1e-16 61.0 6.9 0.017 15.4 0.0 7.5 2 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain CLTH PF10607.9 ORX53227.1 - 7.7e-05 22.6 0.9 0.00012 22.0 0.9 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain WD40_like PF17005.5 ORX53227.1 - 8e-05 22.1 1.2 0.48 9.7 0.0 3.7 4 1 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 ORX53227.1 - 0.00038 19.2 2.5 1.6 7.3 0.1 4.4 1 1 1 3 3 3 3 Nucleoporin Nup120/160 DUF2255 PF10012.9 ORX53227.1 - 0.01 16.0 0.0 0.041 14.0 0.0 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) LisH PF08513.11 ORX53227.1 - 0.024 14.6 0.4 0.2 11.7 0.2 2.4 2 0 0 2 2 2 0 LisH Med18 PF09637.10 ORX53228.1 - 0.2 11.4 0.0 0.2 11.4 0.0 1.0 1 0 0 1 1 1 0 Med18 protein Ribosomal_S13 PF00416.22 ORX53230.1 - 2.1e-54 183.3 2.7 2.4e-54 183.1 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX53230.1 - 0.0045 15.8 0.0 0.0045 15.8 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) p450 PF00067.22 ORX53232.1 - 2.6e-97 326.5 0.0 3.4e-97 326.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 ORX53232.1 - 4.2e-28 98.4 0.0 1.1e-27 97.0 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX53232.1 - 1.4e-22 80.4 0.3 2.7e-22 79.5 0.3 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX53232.1 - 9.6e-14 52.0 0.0 2e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain GATase_6 PF13522.6 ORX53233.1 - 2.5e-15 56.8 0.0 5.3e-15 55.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ORX53233.1 - 1.8e-13 50.5 0.0 3.3e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 ORX53233.1 - 1.1e-07 31.5 0.0 1.6e-06 27.8 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 ORX53233.1 - 1.5e-06 27.3 0.0 3.7e-06 26.0 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferases class-II HEPN_AbiU2 PF18734.1 ORX53233.1 - 0.064 12.8 0.5 0.8 9.2 0.3 2.1 2 0 0 2 2 2 0 AbiU2 PRTase_2 PF15609.6 ORX53233.1 - 0.15 11.5 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosyl transferase OPA3 PF07047.12 ORX53234.1 - 3.2e-48 162.6 0.1 3.2e-48 162.6 0.1 1.5 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) bZIP_2 PF07716.15 ORX53234.1 - 0.002 18.2 3.5 0.22 11.7 0.4 2.4 1 1 1 2 2 2 2 Basic region leucine zipper TolA_bind_tri PF16331.5 ORX53234.1 - 0.0029 17.6 3.7 0.0049 16.9 3.7 1.3 1 0 0 1 1 1 1 TolA binding protein trimerisation ABC_tran_CTD PF16326.5 ORX53234.1 - 0.057 13.7 2.3 0.12 12.6 1.5 1.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain bZIP_1 PF00170.21 ORX53234.1 - 0.075 13.1 2.4 1.9 8.7 0.2 2.5 1 1 1 2 2 2 0 bZIP transcription factor dCache_2 PF08269.11 ORX53234.1 - 0.096 11.8 0.4 0.15 11.2 0.4 1.3 1 0 0 1 1 1 0 Cache domain NYD-SP28_assoc PF14775.6 ORX53234.1 - 0.1 12.7 3.3 1.1 9.4 0.6 2.3 1 1 1 2 2 2 0 Sperm tail C-terminal domain UCR_UQCRX_QCR9 PF05365.12 ORX53234.1 - 0.11 12.5 0.2 0.19 11.7 0.2 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Prefoldin_2 PF01920.20 ORX53234.1 - 0.11 12.4 2.9 0.092 12.7 0.9 1.8 2 0 0 2 2 2 0 Prefoldin subunit Guanylate_cyc_2 PF09778.9 ORX53235.1 - 2.2e-53 180.8 0.5 2.4e-53 180.6 0.5 1.0 1 0 0 1 1 1 1 Guanylylate cyclase Peptidase_C39_2 PF13529.6 ORX53235.1 - 0.00046 20.8 0.0 0.00083 19.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase_C39 like family Peptidase_C70 PF12385.8 ORX53235.1 - 0.019 15.0 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Papain-like cysteine protease AvrRpt2 HMG_CoA_synt_C PF08540.10 ORX53236.1 - 1.8e-98 329.7 3.0 2.3e-98 329.2 3.0 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 ORX53236.1 - 3e-76 255.2 0.9 5.4e-76 254.3 0.7 1.6 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal ACP_syn_III_C PF08541.10 ORX53236.1 - 0.0018 18.4 0.1 0.86 9.8 0.1 2.7 2 0 0 2 2 2 2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal RhoGAP PF00620.27 ORX53237.1 - 3e-38 131.0 0.2 5.9e-38 130.1 0.2 1.5 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX53237.1 - 9.3e-25 86.6 48.6 1.2e-09 38.3 4.1 4.5 4 0 0 4 4 4 4 LIM domain Ank_4 PF13637.6 ORX53239.1 - 9.5e-17 61.1 1.9 2.6e-05 24.7 0.0 4.1 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX53239.1 - 1.1e-11 43.8 0.6 9.1e-06 25.7 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 ORX53239.1 - 5.1e-11 42.5 0.2 6.9e-07 29.4 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ORX53239.1 - 8.2e-11 42.4 0.0 9.7e-06 26.1 0.0 2.5 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX53239.1 - 9.6e-07 29.0 0.2 6.6e-05 23.1 0.0 3.3 2 2 1 3 3 3 1 Ankyrin repeats (many copies) RRM_1 PF00076.22 ORX53240.1 - 0.0032 17.3 0.4 0.0086 15.9 0.4 1.7 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Cyclin_N PF00134.23 ORX53241.1 - 0.0029 17.4 0.1 0.0045 16.7 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Phosphodiest PF01663.22 ORX53242.1 - 1.7e-63 215.4 4.6 2.1e-63 215.1 4.6 1.1 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX53242.1 - 0.00016 21.2 0.2 0.00043 19.8 0.0 1.8 2 0 0 2 2 2 1 Sulfatase Metalloenzyme PF01676.18 ORX53242.1 - 0.0004 19.8 0.3 0.00061 19.2 0.3 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily PglZ PF08665.12 ORX53242.1 - 0.0035 17.5 0.1 0.0056 16.8 0.1 1.4 1 0 0 1 1 1 1 PglZ domain DUF1501 PF07394.12 ORX53242.1 - 0.023 13.8 0.2 0.034 13.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) PC-Esterase PF13839.6 ORX53243.1 - 2.6e-11 43.8 0.0 3.9e-11 43.2 0.0 1.3 1 0 0 1 1 1 1 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p BTB PF00651.31 ORX53244.1 - 0.001 19.3 0.2 0.93 9.7 0.0 2.5 2 0 0 2 2 2 2 BTB/POZ domain UPF1_Zn_bind PF09416.10 ORX53246.1 - 4.9e-75 250.6 4.2 1.6e-74 249.0 3.6 2.0 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 ORX53246.1 - 5.3e-59 199.2 0.0 9e-59 198.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX53246.1 - 2e-50 172.0 2.2 1.9e-28 100.0 0.2 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 ORX53246.1 - 9e-33 112.4 0.0 1.8e-32 111.4 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 ORX53246.1 - 1.5e-14 54.2 0.1 7.5e-14 51.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX53246.1 - 1.6e-11 44.8 0.1 6e-11 42.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ORX53246.1 - 1.5e-06 28.1 0.1 0.05 13.3 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 ORX53246.1 - 3e-05 24.1 0.3 7e-05 22.9 0.0 1.8 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ORX53246.1 - 0.00013 21.3 0.5 0.0043 16.3 0.0 2.9 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 ORX53246.1 - 0.00024 21.0 0.2 0.0012 18.7 0.2 2.1 1 1 0 1 1 1 1 Helicase PIF1 PF05970.14 ORX53246.1 - 0.015 14.5 0.1 0.71 9.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase SRP54 PF00448.22 ORX53246.1 - 0.016 14.8 0.0 0.029 14.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_10 PF12846.7 ORX53246.1 - 0.017 14.1 0.0 0.03 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain DEAD PF00270.29 ORX53246.1 - 0.025 14.3 0.1 0.063 13.0 0.1 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX53246.1 - 0.027 14.7 0.0 0.094 13.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 ORX53246.1 - 0.062 12.7 0.0 0.21 11.0 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein Ribosomal_S13_N PF08069.12 ORX53246.1 - 0.086 12.9 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain ATPase PF06745.13 ORX53246.1 - 0.089 12.1 0.0 0.31 10.4 0.0 1.7 2 0 0 2 2 2 0 KaiC Prok-RING_2 PF14445.6 ORX53246.1 - 0.13 12.4 2.1 0.3 11.3 2.1 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 2 AAA PF00004.29 ORX53246.1 - 0.15 12.5 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX53246.1 - 0.19 11.7 0.0 0.51 10.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Nucleoporin_C PF03177.14 ORX53248.1 - 8.2e-13 48.0 2.0 1.7e-12 46.9 2.0 1.5 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal SGS PF05002.15 ORX53248.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.6 1 0 0 1 1 1 0 SGS domain AbiJ_NTD3 PF18860.1 ORX53248.1 - 1.8 8.1 4.0 40 3.7 1.2 2.9 2 1 0 2 2 2 0 AbiJ N-terminal domain 3 Stomoxyn PF11585.8 ORX53249.1 - 0.14 12.2 2.7 0.22 11.6 2.7 1.5 1 1 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn PelG PF16933.5 ORX53250.1 - 0.0083 15.0 0.1 0.011 14.7 0.1 1.1 1 0 0 1 1 1 1 Putative exopolysaccharide Exporter (EPS-E) DUF1754 PF08555.10 ORX53251.1 - 4e-08 33.9 21.6 0.00014 22.6 10.9 2.7 1 1 2 3 3 3 2 Eukaryotic family of unknown function (DUF1754) Myb_DNA-binding PF00249.31 ORX53253.1 - 0.00012 22.1 0.0 0.00022 21.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX53253.1 - 0.00062 20.0 0.4 0.0016 18.7 0.4 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain PIP5K PF01504.18 ORX53253.1 - 0.029 13.6 0.1 0.029 13.6 0.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Macoilin PF09726.9 ORX53253.1 - 0.56 8.7 4.9 0.65 8.5 4.9 1.2 1 0 0 1 1 1 0 Macoilin family GATase PF00117.28 ORX53254.1 - 1.4e-09 38.0 0.1 1.8e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX53254.1 - 0.011 15.5 0.9 0.21 11.3 0.9 2.3 1 1 0 1 1 1 0 Peptidase C26 HTS PF04204.16 ORX53254.1 - 0.12 11.3 0.0 9 5.1 0.0 2.0 2 0 0 2 2 2 0 Homoserine O-succinyltransferase GATase_5 PF13507.6 ORX53254.1 - 0.23 10.5 0.4 6 5.9 0.0 2.3 2 1 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain PPTA PF01239.22 ORX53255.1 - 3.8e-42 140.8 24.5 2.4e-08 33.4 2.5 6.2 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat TPR_17 PF13431.6 ORX53255.1 - 0.44 11.0 5.2 27 5.4 0.0 5.3 7 0 0 7 7 7 0 Tetratricopeptide repeat MFS_1 PF07690.16 ORX53257.1 - 5e-15 55.3 37.9 1.2e-08 34.3 19.7 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 ORX53258.1 - 3.4e-32 111.8 68.4 4.7e-25 88.3 40.5 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ORX53258.1 - 6.8e-06 25.2 1.7 6.8e-06 25.2 1.7 2.9 1 1 2 3 3 3 1 MFS_1 like family FPN1 PF06963.12 ORX53258.1 - 0.00067 18.3 13.0 0.14 10.7 0.5 3.1 2 1 1 3 3 3 3 Ferroportin1 (FPN1) Neurensin PF14927.6 ORX53258.1 - 1 9.1 3.8 10 5.9 0.0 3.4 2 2 1 3 3 3 0 Neurensin Pkinase PF00069.25 ORX53259.1 - 9.1e-73 244.9 0.0 1.4e-72 244.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53259.1 - 3.3e-39 134.7 0.0 5.7e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX53259.1 - 7.1e-06 25.2 0.4 1.4e-05 24.2 0.4 1.5 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX53259.1 - 1.6e-05 25.0 0.5 0.0042 17.0 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX53259.1 - 0.00013 21.4 0.0 0.00037 19.9 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ORX53259.1 - 0.002 17.5 1.7 0.0036 16.7 1.7 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX53259.1 - 0.0056 16.3 1.0 0.011 15.4 1.0 1.4 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 ORX53259.1 - 0.0088 15.6 1.7 0.083 12.5 0.7 2.3 1 1 1 2 2 2 1 Choline/ethanolamine kinase CoaE PF01121.20 ORX53259.1 - 0.15 11.7 0.2 0.3 10.7 0.2 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase adh_short PF00106.25 ORX53260.1 - 2.3e-45 154.4 0.1 3.8e-45 153.7 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX53260.1 - 6.7e-35 120.7 0.1 9.2e-35 120.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX53260.1 - 5.6e-11 42.7 0.1 7.9e-11 42.2 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX53260.1 - 2.9e-06 26.9 0.3 5.4e-06 26.1 0.3 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 ORX53260.1 - 0.019 14.9 0.2 0.089 12.8 0.1 1.9 2 0 0 2 2 2 0 Zinc-binding dehydrogenase GDP_Man_Dehyd PF16363.5 ORX53260.1 - 0.026 13.9 0.1 0.045 13.2 0.1 1.6 1 1 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ORX53260.1 - 0.11 11.6 0.0 0.22 10.6 0.0 1.6 1 1 0 1 1 1 0 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 ORX53260.1 - 0.11 12.7 0.1 1.6 9.0 0.0 2.5 2 1 1 3 3 3 0 Saccharopine dehydrogenase NADP binding domain UPF0061 PF02696.14 ORX53261.1 - 2.7e-128 428.7 0.0 3.6e-128 428.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Usp PF00582.26 ORX53263.1 - 5.9e-25 88.4 0.2 8e-25 88.0 0.2 1.2 1 0 0 1 1 1 1 Universal stress protein family YcgL PF05166.13 ORX53263.1 - 0.11 12.9 0.1 0.23 11.9 0.1 1.5 1 0 0 1 1 1 0 YcgL domain AA_permease_2 PF13520.6 ORX53264.1 - 1.7e-56 191.9 47.5 2.1e-56 191.6 47.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX53264.1 - 2.1e-27 95.9 40.7 2.8e-27 95.5 40.7 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1644 PF07800.12 ORX53265.1 - 0.014 15.4 2.1 0.017 15.2 2.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Cnl2_NKP2 PF09447.10 ORX53265.1 - 0.017 15.2 0.9 0.035 14.2 0.6 1.7 1 1 0 1 1 1 0 Cnl2/NKP2 family protein HiaBD2 PF15403.6 ORX53266.1 - 7.4 7.0 6.2 17 5.9 0.0 3.6 3 0 0 3 3 3 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) OrfB_Zn_ribbon PF07282.11 ORX53471.1 - 2.4e-09 37.0 1.1 6.8e-09 35.5 0.3 2.2 2 0 0 2 2 2 1 Putative transposase DNA-binding domain RNHCP PF12647.7 ORX53471.1 - 0.025 14.5 0.4 0.025 14.5 0.4 2.0 2 0 0 2 2 2 0 RNHCP domain DZR PF12773.7 ORX53471.1 - 0.047 13.7 1.0 0.12 12.4 1.0 1.6 1 0 0 1 1 1 0 Double zinc ribbon Zip PF02535.22 ORX53471.1 - 0.052 12.7 0.7 0.073 12.3 0.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Exonuc_VII_L PF02601.15 ORX53471.1 - 8.8 5.8 8.5 14 5.1 8.5 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Prok-RING_1 PF14446.6 ORX53472.1 - 1.1 9.2 7.1 1.7 8.6 1.6 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 ORX53472.1 - 2 8.6 4.2 11 6.3 0.3 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-CCHC_6 PF15288.6 ORX53472.1 - 2 8.3 8.9 8.1 6.4 1.0 2.6 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 ORX53472.1 - 6.6 6.9 8.1 67 3.6 8.1 2.3 1 1 0 1 1 1 0 Double zinc ribbon Forkhead PF00250.18 ORX53476.1 - 4.6e-38 129.3 0.2 1.1e-37 128.2 0.0 1.7 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 ORX53476.1 - 5e-11 42.8 0.0 1.1e-10 41.7 0.0 1.6 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 ORX53476.1 - 0.15 12.3 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 FHA domain Malic_M PF03949.15 ORX53477.1 - 1.6e-86 289.7 0.2 2.7e-86 289.0 0.2 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX53477.1 - 1.6e-56 191.0 0.0 2.6e-56 190.3 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain PDEase_I PF00233.19 ORX53478.1 - 5e-68 229.4 5.9 6.3e-37 127.6 7.2 2.4 2 1 1 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ORX53478.1 - 0.00028 21.1 0.0 0.00074 19.7 0.0 1.7 1 0 0 1 1 1 1 HD domain CAP_N PF01213.19 ORX53478.1 - 0.027 14.0 0.9 0.027 14.0 0.9 2.5 3 0 0 3 3 3 0 Adenylate cyclase associated (CAP) N terminal Sulfate_transp PF00916.20 ORX53479.1 - 7.5e-62 209.3 20.9 1.1e-61 208.7 20.9 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX53479.1 - 1.8e-13 50.2 0.0 7.1e-13 48.2 0.0 2.0 2 0 0 2 2 2 1 STAS domain cNMP_binding PF00027.29 ORX53479.1 - 1.3e-12 47.6 0.0 4.4e-12 45.9 0.0 1.9 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain FAD-oxidase_C PF02913.19 ORX53480.1 - 7.8e-50 169.8 0.0 9.7e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX53480.1 - 2.1e-37 128.0 0.3 1.3e-36 125.4 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain DDE_3 PF13358.6 ORX53481.1 - 0.0005 19.8 0.3 0.00079 19.2 0.1 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease ocr PF08684.10 ORX53481.1 - 0.0018 18.7 0.0 0.002 18.6 0.0 1.1 1 0 0 1 1 1 1 DNA mimic ocr HTH_Tnp_Tc3_2 PF01498.18 ORX53482.1 - 0.025 14.8 0.0 0.046 14.0 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_32 PF13565.6 ORX53482.1 - 0.031 14.9 0.0 0.046 14.4 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain SWIM PF04434.17 ORX53485.1 - 0.0011 18.6 0.0 0.0015 18.2 0.0 1.2 1 0 0 1 1 1 1 SWIM zinc finger DUF1612 PF07756.12 ORX53486.1 - 0.21 11.8 9.1 0.3 11.3 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF1612) DUF728 PF05304.12 ORX53486.1 - 0.83 9.5 3.4 1.1 9.1 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF728) DUF4200 PF13863.6 ORX53486.1 - 2.2 8.7 17.3 0.18 12.2 2.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) DUF2390 PF09523.10 ORX53486.1 - 9.6 6.6 16.0 5.2 7.4 5.7 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2390) DUF1644 PF07800.12 ORX53487.1 - 0.021 14.9 4.1 0.019 15.1 1.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) DUF4298 PF14131.6 ORX53487.1 - 0.22 11.5 0.5 0.62 10.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) CBM26 PF16738.5 ORX53488.1 - 2 8.8 6.0 36 4.7 0.1 3.0 2 1 1 3 3 3 0 Starch-binding module 26 zf-C2H2 PF00096.26 ORX53489.1 - 1.1e-06 28.7 8.6 0.008 16.6 0.8 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 ORX53489.1 - 2.3e-05 23.9 1.3 0.021 14.4 0.1 2.8 3 0 0 3 3 3 2 Zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ORX53489.1 - 5.2e-05 23.4 0.9 0.002 18.4 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX53489.1 - 7.3e-05 23.3 8.1 0.04 14.7 0.9 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX53489.1 - 0.00075 19.2 1.0 0.0018 18.0 1.0 1.6 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-met PF12874.7 ORX53489.1 - 0.0011 19.3 2.6 0.0013 19.0 0.3 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF629 PF04780.12 ORX53489.1 - 0.019 13.5 1.2 0.19 10.2 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_aberr PF17017.5 ORX53489.1 - 0.034 14.3 0.0 0.072 13.2 0.0 1.6 1 0 0 1 1 1 0 Aberrant zinc-finger zf_C2H2_ZHX PF18387.1 ORX53489.1 - 0.046 13.4 10.5 0.44 10.2 0.2 2.9 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-LYAR PF08790.11 ORX53489.1 - 0.084 12.8 2.4 3.4 7.7 0.1 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf_Hakai PF18408.1 ORX53489.1 - 0.11 12.2 0.9 4.9 6.9 0.1 2.4 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_2 PF12756.7 ORX53489.1 - 0.14 12.5 1.7 0.66 10.3 0.2 2.3 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 ORX53489.1 - 0.3 11.1 3.9 0.3 11.2 0.5 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 ORX53489.1 - 7.5 6.9 8.5 17 5.8 0.4 3.1 4 0 0 4 4 2 0 Drought induced 19 protein (Di19), zinc-binding RabGAP-TBC PF00566.18 ORX53490.1 - 1.5e-36 126.1 0.0 3e-36 125.1 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain FdhE PF04216.12 ORX53490.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Meleagrin PF08189.11 ORX53490.1 - 0.25 11.0 1.4 0.58 9.9 1.4 1.5 1 0 0 1 1 1 0 Meleagrin/Cygnin family Lon_C PF05362.13 ORX53491.1 - 1.8e-74 249.7 0.3 4.7e-74 248.4 0.2 1.7 2 0 0 2 2 2 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ORX53491.1 - 1.1e-26 94.0 0.2 4.3e-26 92.1 0.0 2.0 2 0 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ORX53491.1 - 1.8e-21 76.9 0.0 1e-20 74.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 ORX53491.1 - 1e-06 28.6 0.0 2.4e-06 27.4 0.0 1.7 1 1 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ORX53491.1 - 3.1e-06 27.3 0.0 1.6e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_PrkA PF08298.11 ORX53491.1 - 5.8e-06 25.5 0.0 1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_3 PF07726.11 ORX53491.1 - 0.0001 22.2 0.0 0.00025 20.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ORX53491.1 - 0.00043 20.0 0.0 0.0012 18.7 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX53491.1 - 0.00048 20.3 0.0 0.0013 18.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX53491.1 - 0.00079 19.8 0.1 0.0057 17.1 0.0 2.5 3 0 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX53491.1 - 0.0023 18.2 0.0 0.066 13.5 0.0 2.7 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ORX53491.1 - 0.0023 17.8 0.0 0.0088 16.0 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 ORX53491.1 - 0.015 15.7 0.0 0.085 13.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 ORX53491.1 - 0.035 13.8 0.0 0.12 12.1 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein NACHT PF05729.12 ORX53491.1 - 0.037 14.0 0.1 0.98 9.3 0.0 3.1 3 0 0 3 3 3 0 NACHT domain IL31 PF15209.6 ORX53491.1 - 0.045 13.5 0.0 0.2 11.4 0.0 2.1 1 0 0 1 1 1 0 Interleukin 31 AAA_23 PF13476.6 ORX53491.1 - 0.063 13.8 5.9 0.2 12.1 0.0 2.5 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ORX53491.1 - 0.091 11.9 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ORX53491.1 - 0.13 12.8 0.0 0.38 11.3 0.0 1.8 1 0 0 1 1 1 0 AAA domain MFAP1 PF06991.11 ORX53491.1 - 2.4 8.0 5.7 12 5.7 2.7 2.2 1 1 1 2 2 2 0 Microfibril-associated/Pre-mRNA processing Occludin_ELL PF07303.13 ORX53491.1 - 3.4 8.4 4.7 9.8 7.0 0.5 2.9 2 1 0 2 2 2 0 Occludin homology domain Na_H_Exchanger PF00999.21 ORX53493.1 - 2e-62 211.2 24.3 2.5e-62 210.9 24.3 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family CstA PF02554.14 ORX53493.1 - 0.0021 17.0 5.1 0.0021 17.0 5.1 2.3 2 0 0 2 2 2 2 Carbon starvation protein CstA OrfB_Zn_ribbon PF07282.11 ORX53494.1 - 7.3e-08 32.2 2.9 1.3e-07 31.4 2.9 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX53494.1 - 0.011 15.5 1.5 0.018 14.7 1.5 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal DUF4503 PF14951.6 ORX53494.1 - 0.046 12.2 1.4 0.066 11.7 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) GTP_EFTU PF00009.27 ORX53495.1 - 1.3e-55 188.0 0.0 2.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX53495.1 - 7.2e-42 142.2 0.0 1.5e-41 141.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX53495.1 - 1.7e-14 53.9 1.2 1.7e-14 53.9 1.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX53495.1 - 0.00066 19.8 0.1 0.014 15.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2011 PF09428.10 ORX53497.1 - 0.00025 21.2 0.1 0.0021 18.3 0.1 2.4 1 1 0 1 1 1 1 Fungal protein of unknown function (DUF2011) She2p PF11435.8 ORX53497.1 - 0.037 13.7 0.4 0.049 13.3 0.4 1.2 1 0 0 1 1 1 0 RNA binding protein She2p ADK PF00406.22 ORX53498.1 - 1.1e-09 38.6 0.6 1.7e-08 34.7 0.1 2.5 2 1 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 ORX53498.1 - 0.0013 19.2 0.0 0.0065 16.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX53498.1 - 0.11 13.0 1.6 0.69 10.4 0.6 2.5 2 1 0 2 2 2 0 ABC transporter MFS_1 PF07690.16 ORX53499.1 - 3.3e-31 108.5 12.6 3.3e-31 108.5 12.6 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX53499.1 - 1.9e-08 33.6 4.0 1.9e-08 33.6 4.0 2.4 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 ORX53499.1 - 0.0075 15.2 15.7 0.081 11.8 1.5 2.9 2 1 1 3 3 3 3 MFS_1 like family HU-CCDC81_bac_1 PF18174.1 ORX53499.1 - 0.064 13.2 0.1 0.17 11.8 0.1 1.6 1 0 0 1 1 1 0 CCDC81-like prokaryotic HU domain 1 Pex14_N PF04695.13 ORX53499.1 - 0.17 12.6 0.8 0.35 11.5 0.8 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Peptidase_C12 PF01088.21 ORX53500.1 - 1.1e-71 240.9 0.0 1.8e-71 240.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 ORX53500.1 - 1.4e-15 56.9 5.6 1.4e-15 56.9 5.6 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases DHHA2 PF02833.14 ORX53500.1 - 0.086 13.0 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 DHHA2 domain DUF3425 PF11905.8 ORX53501.1 - 4.3e-13 49.3 0.6 2.1e-12 47.1 0.6 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ORX53501.1 - 2.6e-06 27.4 7.6 2.6e-06 27.4 7.6 2.3 2 0 0 2 2 2 1 bZIP transcription factor eIF3_subunit PF08597.10 ORX53501.1 - 0.098 12.6 0.2 0.098 12.6 0.2 1.9 1 1 1 2 2 2 0 Translation initiation factor eIF3 subunit SHE3 PF17078.5 ORX53501.1 - 1.2 8.7 10.9 0.066 12.9 4.2 2.0 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 ORX53501.1 - 6.2 7.4 16.4 0.9 10.1 9.7 2.6 2 0 0 2 2 2 0 bZIP Maf transcription factor Cu-oxidase PF00394.22 ORX53502.1 - 4.1e-31 108.2 0.0 1.1e-30 106.8 0.0 1.8 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX53502.1 - 1.2e-26 93.0 4.0 2.1e-20 72.9 0.4 3.0 2 1 1 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX53502.1 - 6.5e-26 90.7 13.1 7e-25 87.4 2.6 3.9 3 2 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 ORX53503.1 - 8.5e-27 94.2 0.0 3.2e-26 92.4 0.0 2.0 3 0 0 3 3 3 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX53503.1 - 3.3e-26 91.6 7.8 9.4e-25 86.9 0.6 3.7 3 1 0 3 3 3 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 ORX53503.1 - 7.7e-23 80.7 16.5 1.3e-18 67.0 6.5 4.7 3 2 0 3 3 3 2 Multicopper oxidase RA PF00788.23 ORX53504.1 - 1.3e-10 41.8 0.0 1.1e-05 26.0 0.0 3.1 3 0 0 3 3 3 2 Ras association (RalGDS/AF-6) domain SH3_1 PF00018.28 ORX53504.1 - 2.2e-07 30.4 0.0 4.7e-07 29.3 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX53504.1 - 2.2e-05 24.2 0.0 3.8e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX53504.1 - 0.0021 18.3 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain Ring_hydroxyl_A PF00848.19 ORX53505.1 - 0.08 12.9 0.3 0.13 12.2 0.3 1.3 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) DUF5005 PF16396.5 ORX53505.1 - 0.2 10.3 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5005) PRP1_N PF06424.12 ORX53507.1 - 1.3e-48 165.2 5.2 3.4e-48 163.8 5.2 1.8 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 ORX53507.1 - 1e-37 125.6 21.7 0.00075 20.1 0.4 14.1 4 3 10 14 14 14 10 Tetratricopeptide repeat TPR_19 PF14559.6 ORX53507.1 - 1.2e-25 89.7 7.3 1.5e-06 28.6 0.1 9.4 6 3 1 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53507.1 - 2.5e-15 56.8 5.5 0.014 16.1 0.0 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX53507.1 - 1.4e-14 52.9 8.1 0.81 10.0 0.0 11.5 15 0 0 15 15 13 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX53507.1 - 2.5e-13 49.4 1.8 0.15 12.5 0.0 9.0 8 1 1 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX53507.1 - 1e-12 47.2 0.1 0.16 12.3 0.0 8.7 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX53507.1 - 9.1e-11 41.7 4.0 3.9 8.3 0.0 10.1 11 0 0 11 11 9 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53507.1 - 7.8e-08 31.8 0.1 1.6 8.7 0.0 6.5 9 0 0 9 9 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX53507.1 - 8.7e-08 31.7 0.1 0.39 10.4 0.0 6.2 7 0 0 7 7 7 1 TPR repeat TPR_21 PF09976.9 ORX53507.1 - 1.7e-06 27.9 5.7 0.02 14.6 0.7 5.0 3 1 1 4 4 4 2 Tetratricopeptide repeat-like domain NRDE-2 PF08424.10 ORX53507.1 - 3.8e-06 26.3 14.0 0.0067 15.6 0.4 5.3 2 2 4 6 6 6 3 NRDE-2, necessary for RNA interference TPR_12 PF13424.6 ORX53507.1 - 0.00037 20.7 3.4 29 5.1 0.1 6.3 4 2 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX53507.1 - 0.0014 18.8 1.7 1.6 9.0 0.1 4.6 4 1 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ORX53507.1 - 0.0033 17.2 1.7 8.5 6.4 0.1 4.8 4 0 0 4 4 3 0 Tetratricopeptide repeat FAT PF02259.23 ORX53507.1 - 0.0072 15.6 12.9 0.09 12.0 3.6 3.6 2 1 0 3 3 3 2 FAT domain TPR_9 PF13371.6 ORX53507.1 - 0.012 15.8 7.3 24 5.1 0.0 6.0 8 1 0 8 8 6 0 Tetratricopeptide repeat NARP1 PF12569.8 ORX53507.1 - 0.02 13.8 12.4 0.24 10.2 0.3 5.2 4 1 2 6 6 6 0 NMDA receptor-regulated protein 1 DUF3808 PF10300.9 ORX53507.1 - 0.036 12.8 0.2 0.68 8.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3808) Wzy_C_2 PF11846.8 ORX53507.1 - 0.038 13.9 2.5 1.9 8.4 0.0 3.9 3 1 1 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal DUF1955 PF09205.10 ORX53507.1 - 0.057 13.2 0.2 0.33 10.7 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1955) Spatacsin_C PF14649.6 ORX53507.1 - 0.12 11.4 0.3 0.22 10.6 0.3 1.4 1 0 0 1 1 1 0 Spatacsin C-terminus CP12 PF02672.15 ORX53507.1 - 0.67 10.7 4.5 0.99 10.2 0.5 3.3 2 0 0 2 2 2 0 CP12 domain Suf PF05843.14 ORX53507.1 - 1.4 8.8 6.5 24 4.8 0.0 4.8 4 1 2 6 6 5 0 Suppressor of forked protein (Suf) TPR_4 PF07721.14 ORX53507.1 - 1.7 9.5 9.3 35 5.4 0.1 4.9 4 0 0 4 4 3 0 Tetratricopeptide repeat EB PF01683.18 ORX53508.1 - 0.088 13.1 3.0 0.18 12.1 3.0 1.5 1 1 0 1 1 1 0 EB module Dickkopf_N PF04706.12 ORX53508.1 - 0.16 12.5 6.2 0.26 11.8 6.2 1.3 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region STE PF02200.16 ORX53509.1 - 0.00025 21.4 0.1 0.00045 20.6 0.1 1.4 1 1 0 1 1 1 1 STE like transcription factor Lipase_3 PF01764.25 ORX53510.1 - 8.6e-15 54.8 0.0 1.9e-14 53.7 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) Uso1_p115_C PF04871.13 ORX53511.1 - 2e-06 28.2 0.2 2.5e-06 27.9 0.2 1.0 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, C terminal region WD40 PF00400.32 ORX53512.1 - 5.4e-28 96.7 13.4 2.3e-07 31.4 0.0 8.0 8 0 0 8 8 8 5 WD domain, G-beta repeat Bromodomain PF00439.25 ORX53512.1 - 9.6e-13 48.0 0.1 2.2e-12 46.8 0.1 1.6 1 0 0 1 1 1 1 Bromodomain ANAPC4_WD40 PF12894.7 ORX53512.1 - 1.8e-06 28.1 0.0 0.86 9.9 0.0 4.9 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX53512.1 - 0.00079 18.5 0.0 2.1 7.2 0.0 3.7 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SecE PF00584.20 ORX53513.1 - 1.8e-13 50.2 0.0 2.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex DUF383 PF04063.14 ORX53514.1 - 2.7e-58 196.8 0.0 5.2e-58 195.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF383) Arm_2 PF04826.13 ORX53514.1 - 0.031 13.7 0.2 36 3.7 0.0 3.1 3 0 0 3 3 3 0 Armadillo-like PP-binding PF00550.25 ORX53515.1 - 2.5e-14 53.4 0.5 3.2e-14 53.0 0.5 1.1 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ORX53515.1 - 5.3e-05 23.4 0.4 6.3e-05 23.1 0.4 1.2 1 0 0 1 1 1 1 Acyl-carrier hnRNP_Q_AcD PF18360.1 ORX53515.1 - 0.016 15.1 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain PAC1 PF16094.5 ORX53517.1 - 5.4e-13 48.8 0.0 6.4e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 Pox_TAP PF03355.14 ORX53518.1 - 2.3 7.7 7.0 1.7 8.1 1.4 2.4 1 1 1 2 2 2 0 Viral Trans-Activator Protein DUF21 PF01595.20 ORX53519.1 - 1.2e-18 67.5 0.4 7.5e-08 32.3 0.9 2.4 3 0 0 3 3 3 2 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ORX53519.1 - 2.3e-06 28.0 0.4 0.006 17.0 0.0 2.7 3 0 0 3 3 3 2 CBS domain Glyco_trans_1_3 PF13528.6 ORX53520.1 - 1.3e-06 27.9 0.0 0.0002 20.7 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Cob_adeno_trans PF01923.18 ORX53520.1 - 0.033 14.3 0.0 0.065 13.4 0.0 1.4 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Glyco_tran_28_C PF04101.16 ORX53520.1 - 0.053 13.5 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Prp19 PF08606.11 ORX53521.1 - 7.2e-34 115.6 2.1 1.3e-33 114.8 2.1 1.4 1 0 0 1 1 1 1 Prp19/Pso4-like WD40 PF00400.32 ORX53521.1 - 1.2e-33 114.5 9.8 4.8e-05 24.0 0.0 7.3 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX53521.1 - 1.5e-21 76.5 0.0 2.1e-05 24.7 0.0 5.9 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX53521.1 - 8e-05 21.7 0.0 0.29 10.1 0.0 3.0 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX53521.1 - 0.00014 20.7 0.7 0.19 10.3 0.0 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF3450 PF11932.8 ORX53521.1 - 0.015 14.6 1.7 0.025 13.9 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) SGL PF08450.12 ORX53521.1 - 0.017 14.7 0.1 0.82 9.2 0.0 2.5 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Glyco_transf_15 PF01793.16 ORX53522.1 - 1.1e-119 399.5 7.9 1.4e-119 399.2 7.9 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DAPDH_C PF16654.5 ORX53522.1 - 0.038 13.8 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain Ints3 PF10189.9 ORX53524.1 - 1.2e-71 240.6 2.7 2.2e-71 239.7 2.7 1.4 1 0 0 1 1 1 1 Integrator complex subunit 3 Pkinase PF00069.25 ORX53525.1 - 4.6e-47 160.6 0.0 7.2e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53525.1 - 3.2e-21 75.8 0.0 1.1e-20 74.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX53525.1 - 1.6e-08 34.3 0.0 2.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX53525.1 - 4.4e-07 29.5 0.0 7.3e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX53525.1 - 1.8e-06 28.1 0.0 0.016 15.1 0.1 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 ORX53525.1 - 0.00017 21.3 0.0 0.00032 20.4 0.0 1.4 1 0 0 1 1 1 1 RIO1 family Pkinase_fungal PF17667.1 ORX53525.1 - 1.5 7.5 5.7 3.2 6.4 0.0 3.1 3 1 1 4 4 4 0 Fungal protein kinase Mito_carr PF00153.27 ORX53526.1 - 2.3e-57 190.9 6.0 9.8e-20 70.3 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Antimicrobial_6 PF08036.11 ORX53526.1 - 0.024 14.7 0.7 22 5.2 0.1 3.3 3 0 0 3 3 3 0 Diapausin family of antimicrobial peptide NDK PF00334.19 ORX53527.1 - 1.6e-49 167.4 0.0 1.9e-49 167.1 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Trm112p PF03966.16 ORX53528.1 - 2.8e-15 56.6 0.1 3.5e-15 56.3 0.1 1.1 1 0 0 1 1 1 1 Trm112p-like protein His_kinase PF06580.13 ORX53528.1 - 0.041 14.2 0.1 0.066 13.5 0.1 1.6 1 1 0 1 1 1 0 Histidine kinase DUF244 PF03112.14 ORX53529.1 - 0.022 14.6 1.4 0.022 14.6 1.4 1.7 2 0 0 2 2 2 0 Uncharacterized protein family (ORF7) DUF CCDC50_N PF15295.6 ORX53530.1 - 0.21 11.8 7.0 0.38 10.9 7.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus ATP-synt_ab PF00006.25 ORX53531.1 - 1e-71 241.0 0.0 1.5e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ORX53531.1 - 1.3e-46 158.0 0.0 2.3e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ORX53531.1 - 3.3e-20 72.4 1.1 8.5e-20 71.1 1.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 ORX53531.1 - 0.019 15.1 0.2 0.059 13.5 0.2 1.9 1 1 0 1 1 1 0 HAS barrel domain tRNA-synt_1b PF00579.25 ORX53532.1 - 1.7e-74 250.8 0.0 2.2e-74 250.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) S4 PF01479.25 ORX53532.1 - 5.7e-06 26.0 0.2 1.1e-05 25.1 0.2 1.5 1 0 0 1 1 1 1 S4 domain HTH_psq PF05225.16 ORX53533.1 - 0.17 11.7 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain V_ATPase_I PF01496.19 ORX53534.1 - 0.13 10.1 4.1 0.16 9.9 4.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MCD_N PF17408.2 ORX53534.1 - 0.27 11.4 4.9 0.61 10.2 4.9 1.7 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase N-terminal domain DUF501 PF04417.12 ORX53534.1 - 0.86 9.4 5.5 0.68 9.7 3.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF501) Phlebovirus_NSM PF07246.11 ORX53534.1 - 4 6.7 6.9 5.7 6.2 6.9 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Suppressor_APC PF11414.8 ORX53534.1 - 6 7.0 14.0 0.22 11.6 6.6 2.3 2 1 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein SRP-alpha_N PF04086.13 ORX53535.1 - 7.3e-51 173.8 12.4 1e-49 170.0 12.4 2.0 1 1 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 ORX53535.1 - 7.5e-49 166.0 0.3 1.5e-48 165.1 0.3 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 ORX53535.1 - 1.3e-08 35.0 1.2 4.2e-08 33.3 0.0 2.6 3 0 0 3 3 3 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 ORX53535.1 - 9.7e-08 31.3 2.8 6.8e-07 28.5 0.0 2.3 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 ORX53535.1 - 0.0089 15.8 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ORX53535.1 - 0.047 13.7 0.0 0.39 10.8 0.0 2.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ORX53535.1 - 0.06 13.3 0.1 0.57 10.1 0.0 2.3 1 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 ORX53535.1 - 0.07 13.2 0.5 0.75 9.9 0.5 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Fer4_NifH PF00142.18 ORX53535.1 - 0.072 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family zf-U1 PF06220.12 ORX53536.1 - 3.4e-22 77.9 4.2 5.3e-22 77.3 4.2 1.3 1 0 0 1 1 1 1 U1 zinc finger Peptidase_M35 PF02102.15 ORX53536.1 - 0.024 13.5 0.3 0.033 13.1 0.3 1.1 1 0 0 1 1 1 0 Deuterolysin metalloprotease (M35) family Mannosyl_trans2 PF04188.13 ORX53537.1 - 2.1e-69 234.9 35.6 3.3e-69 234.3 35.6 1.3 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) tRNA_edit PF04073.15 ORX53538.1 - 2.9e-05 24.1 0.0 3.8e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Pep3_Vps18 PF05131.14 ORX53539.1 - 1.1e-52 177.8 0.1 3e-52 176.4 0.1 1.8 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 ORX53539.1 - 1.3e-09 38.0 1.8 1.3e-09 38.0 1.8 3.8 3 2 2 5 5 5 2 Region in Clathrin and VPS zf-C3HC4_2 PF13923.6 ORX53539.1 - 1.7e-05 24.5 1.6 4.8e-05 23.1 1.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX53539.1 - 0.0004 20.7 1.0 0.0011 19.2 1.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX53539.1 - 0.00055 19.9 1.8 0.0014 18.6 1.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_11 PF17123.5 ORX53539.1 - 0.00056 19.6 3.0 0.00056 19.6 3.0 1.9 2 0 0 2 2 2 1 RING-like zinc finger Nup54_57_C PF18570.1 ORX53539.1 - 0.00071 19.1 0.4 0.0018 17.8 0.4 1.7 1 0 0 1 1 1 1 NUP57/Nup54 C-terminal domain zf-RING_5 PF14634.6 ORX53539.1 - 0.0022 17.9 0.6 0.0055 16.6 0.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ORX53539.1 - 0.0064 16.1 0.4 0.015 14.9 0.4 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 ORX53539.1 - 0.007 16.6 0.4 0.027 14.8 0.4 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX53539.1 - 0.022 14.6 1.2 0.053 13.4 1.2 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Syntaxin-6_N PF09177.11 ORX53539.1 - 0.042 14.4 0.1 0.13 12.9 0.1 1.8 1 0 0 1 1 1 0 Syntaxin 6, N-terminal zf-ANAPC11 PF12861.7 ORX53539.1 - 0.14 12.2 0.4 0.54 10.4 0.4 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3H2C3 PF17122.5 ORX53539.1 - 0.44 10.6 3.7 0.2 11.7 0.9 1.9 2 0 0 2 2 2 0 Zinc-finger RXT2_N PF08595.11 ORX53540.1 - 0.0032 17.5 1.3 0.0036 17.3 1.3 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 ORX53540.1 - 0.017 14.9 4.0 0.021 14.5 4.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BDHCT_assoc PF16204.5 ORX53540.1 - 0.027 14.2 1.9 0.033 13.9 1.9 1.1 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein NOA36 PF06524.12 ORX53540.1 - 0.037 13.4 6.7 0.047 13.0 6.7 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ORX53540.1 - 0.05 14.0 2.4 0.05 14.0 2.4 1.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ORX53540.1 - 0.18 11.5 1.7 0.27 10.9 1.7 1.3 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ORX53540.1 - 0.21 9.6 3.1 0.2 9.7 3.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ORX53540.1 - 0.58 10.6 10.6 0.89 10.0 10.6 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pkinase PF00069.25 ORX53542.1 - 2.6e-60 204.0 0.0 3.7e-60 203.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53542.1 - 1.7e-43 148.8 0.0 2.5e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX53542.1 - 4.2e-06 25.8 0.0 9.4e-06 24.6 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX53542.1 - 8.5e-06 25.3 0.0 1.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX53542.1 - 0.039 12.9 0.0 0.44 9.4 0.0 2.4 1 1 0 1 1 1 0 Haspin like kinase domain ATG16 PF08614.11 ORX53542.1 - 0.11 12.7 3.1 0.35 11.0 3.1 1.8 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Peptidase_C10 PF01640.17 ORX53542.1 - 0.18 12.1 0.0 1.3 9.3 0.0 2.0 2 0 0 2 2 2 0 Peptidase C10 family Ribosomal_S4e PF00900.20 ORX53543.1 - 3.4e-38 129.4 0.5 3.4e-38 129.4 0.5 2.4 3 0 0 3 3 3 1 Ribosomal family S4e 40S_S4_C PF16121.5 ORX53543.1 - 1.9e-26 91.4 0.1 3.5e-26 90.6 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 ORX53543.1 - 6.1e-19 67.8 6.2 1.3e-18 66.8 6.2 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 ORX53543.1 - 5.3e-06 26.0 0.0 1.3e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 S4 domain KOW PF00467.29 ORX53543.1 - 2.1e-05 24.3 6.2 5.9e-05 22.9 5.3 2.3 2 0 0 2 2 2 1 KOW motif Sipho_tail PF05709.11 ORX53543.1 - 0.081 12.3 0.2 0.14 11.5 0.2 1.4 1 1 0 1 1 1 0 Phage tail protein Oxidored_q6 PF01058.22 ORX53544.1 - 6.2e-23 81.1 0.1 1e-22 80.3 0.1 1.4 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit BP28CT PF08146.12 ORX53545.1 - 2.4e-36 125.0 1.2 2.4e-36 125.0 1.2 3.3 4 0 0 4 4 4 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 ORX53545.1 - 4.2e-18 65.8 4.1 4.2e-18 65.8 4.1 4.7 4 1 0 4 4 4 1 U3 small nucleolar RNA-associated protein 10 HEAT_EZ PF13513.6 ORX53545.1 - 1.1e-07 32.2 15.9 0.097 13.2 0.3 7.9 5 2 2 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.6 ORX53545.1 - 4.7e-07 30.1 6.5 0.016 15.6 0.1 6.3 7 0 0 7 7 7 2 HEAT repeats HEAT PF02985.22 ORX53545.1 - 4.1e-06 26.6 9.9 0.0034 17.5 0.1 6.0 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 ORX53545.1 - 7.3e-05 22.9 3.5 4.1 7.4 0.0 5.6 5 0 0 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ORX53545.1 - 0.00099 19.3 7.2 3.5 7.8 0.1 6.7 7 0 0 7 7 7 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 PF11865.8 ORX53545.1 - 0.019 14.9 8.2 0.023 14.6 0.0 4.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) Vac14_Fab1_bd PF12755.7 ORX53545.1 - 0.044 14.4 0.0 45 4.7 0.0 4.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region zf-C2H2 PF00096.26 ORX53546.1 - 6.1e-06 26.4 23.3 0.0023 18.3 7.1 3.7 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX53546.1 - 0.0022 18.3 6.5 0.0022 18.3 6.5 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX53546.1 - 0.0025 18.5 5.4 0.0025 18.5 5.4 3.9 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX53546.1 - 0.0035 17.6 3.1 0.0035 17.6 3.1 2.8 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX53546.1 - 0.0071 17.0 11.5 0.58 10.8 1.2 3.2 1 1 2 3 3 3 2 FOXP coiled-coil domain zf-Di19 PF05605.12 ORX53546.1 - 0.051 13.9 11.9 0.17 12.2 2.3 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ORX53546.1 - 0.12 12.4 8.9 0.094 12.7 5.3 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf_ZIC PF18366.1 ORX53546.1 - 0.13 12.4 0.1 0.13 12.4 0.1 3.4 3 2 0 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_2 PF12756.7 ORX53546.1 - 9.6 6.6 14.6 1.8e+02 2.5 12.9 2.8 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF4265 PF14085.6 ORX53547.1 - 0.14 12.1 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) MDM31_MDM32 PF08118.11 ORX53547.1 - 0.53 8.9 3.7 0.2 10.3 0.8 1.7 2 0 0 2 2 2 0 Yeast mitochondrial distribution and morphology (MDM) proteins WRNPLPNID PF15017.6 ORX53547.1 - 7.8 7.5 9.6 3.9 8.4 6.1 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box COX17 PF05051.13 ORX53548.1 - 1.1e-20 73.7 7.4 1.4e-20 73.4 7.4 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) HTH_5 PF01022.20 ORX53548.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Aminotran_1_2 PF00155.21 ORX53549.1 - 2.8e-26 92.5 0.0 3e-26 92.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ORX53549.1 - 3.2e-06 26.2 0.0 4.3e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Nucleoside_tran PF01733.18 ORX53550.1 - 2.5e-57 194.6 8.2 2.5e-57 194.6 8.2 1.8 2 0 0 2 2 2 1 Nucleoside transporter CD20 PF04103.15 ORX53550.1 - 0.012 15.7 3.9 0.012 15.7 3.9 2.3 2 1 0 2 2 2 0 CD20-like family ENOD93 PF03386.14 ORX53550.1 - 0.041 13.8 3.8 0.097 12.6 3.8 1.6 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein SLATT_3 PF18184.1 ORX53550.1 - 8.8 6.5 10.1 0.97 9.6 0.5 3.2 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 3 TnsD PF15978.5 ORX53551.1 - 0.11 11.4 0.2 0.15 11.0 0.2 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Drc1-Sld2 PF11719.8 ORX53552.1 - 5.2e-08 32.9 27.0 1.9e-07 31.0 12.4 2.7 1 1 1 2 2 2 2 DNA replication and checkpoint protein DivIC PF04977.15 ORX53553.1 - 0.00077 19.2 1.4 0.02 14.6 2.3 2.0 2 0 0 2 2 2 1 Septum formation initiator Hpt PF01627.23 ORX53553.1 - 0.0015 18.7 0.7 0.035 14.4 0.0 2.1 2 0 0 2 2 2 1 Hpt domain ALIX_LYPXL_bnd PF13949.6 ORX53553.1 - 0.0085 15.4 4.7 0.012 14.9 4.7 1.3 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF4404 PF14357.6 ORX53553.1 - 0.048 14.3 6.2 1.7 9.3 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) Rootletin PF15035.6 ORX53553.1 - 0.066 13.2 3.5 0.072 13.1 0.9 1.9 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF349 PF03993.12 ORX53553.1 - 0.13 12.5 3.7 0.84 10.0 1.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) K-box PF01486.17 ORX53553.1 - 0.78 9.9 9.0 5.4 7.3 5.0 2.2 1 1 1 2 2 2 0 K-box region APG6_N PF17675.1 ORX53553.1 - 0.81 10.2 7.5 1.3 9.6 7.5 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF5610 PF18433.1 ORX53555.1 - 0.079 13.5 0.1 0.17 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5610) NikR_C PF08753.11 ORX53555.1 - 0.11 12.6 0.0 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 NikR C terminal nickel binding domain Radical_SAM_C PF16199.5 ORX53558.1 - 1.1e-32 111.9 0.0 2.6e-32 110.7 0.0 1.7 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ORX53558.1 - 1.9e-18 67.4 0.1 8.1e-18 65.3 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ORX53558.1 - 7.6e-10 39.0 0.0 1.5e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX53558.1 - 2.3e-06 27.6 0.0 5.1e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX53558.1 - 0.011 16.1 0.0 0.024 15.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pkinase PF00069.25 ORX53559.1 - 2.2e-75 253.4 0.0 2.5e-75 253.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53559.1 - 1.3e-37 129.5 0.0 1.6e-37 129.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX53559.1 - 3.8e-05 23.1 0.0 6e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX53559.1 - 0.00023 20.3 0.0 0.003 16.6 0.0 2.1 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX53559.1 - 0.066 13.1 0.0 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX53559.1 - 0.11 11.8 0.8 0.25 10.7 0.8 1.6 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2322 PF10084.9 ORX53559.1 - 0.14 12.2 0.0 0.42 10.7 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2322) DUF4423 PF14394.6 ORX53560.1 - 0.00031 20.5 0.4 0.00085 19.1 0.2 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4423) BCAS2 PF05700.11 ORX53560.1 - 0.002 17.9 0.5 0.0023 17.7 0.5 1.0 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) TMF_DNA_bd PF12329.8 ORX53560.1 - 0.021 14.8 0.1 0.039 13.9 0.1 1.3 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Trans_reg_C PF00486.28 ORX53560.1 - 0.026 14.6 0.7 0.049 13.7 0.7 1.6 1 1 0 1 1 1 0 Transcriptional regulatory protein, C terminal TipAS PF07739.13 ORX53560.1 - 0.048 14.2 0.6 0.055 14.0 0.6 1.1 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain DUF2576 PF10845.8 ORX53560.1 - 0.054 13.1 0.5 0.12 12.0 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2576) AKNA PF12443.8 ORX53560.1 - 0.062 13.9 1.0 0.065 13.9 1.0 1.1 1 0 0 1 1 1 0 AT-hook-containing transcription factor YabA PF06156.13 ORX53560.1 - 0.1 13.2 0.3 0.12 13.0 0.3 1.1 1 0 0 1 1 1 0 Initiation control protein YabA Tho2 PF11262.8 ORX53560.1 - 0.11 11.6 0.8 0.11 11.6 0.8 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DivIC PF04977.15 ORX53560.1 - 0.21 11.4 2.7 0.51 10.1 2.7 1.6 1 1 0 1 1 1 0 Septum formation initiator MerR-DNA-bind PF09278.11 ORX53560.1 - 0.55 10.8 5.5 0.97 10.0 0.5 2.0 1 1 1 2 2 2 0 MerR, DNA binding Ribosomal_S3_C PF00189.20 ORX53561.1 - 6.9e-23 81.0 1.3 2e-22 79.5 0.8 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ORX53561.1 - 7.8e-12 44.9 0.1 1.3e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 ORX53561.1 - 0.097 13.2 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 vATP-synt_AC39 PF01992.16 ORX53562.1 - 1.5e-115 386.3 0.8 1.7e-115 386.1 0.8 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Sulfotransfer_4 PF17784.1 ORX53563.1 - 4.7e-53 180.2 0.0 2.2e-51 174.8 0.0 2.0 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ORX53563.1 - 0.00017 22.1 0.0 0.00036 21.0 0.0 1.8 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 ORX53563.1 - 0.023 14.2 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Sulfotransferase domain DnaJ_C PF01556.18 ORX53564.1 - 1e-41 142.5 0.4 1.3e-41 142.1 0.4 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX53564.1 - 1.9e-17 63.1 2.5 3.5e-17 62.3 2.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX53564.1 - 9.8e-13 48.3 19.9 1.7e-12 47.5 19.9 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ORX53564.1 - 0.018 15.0 15.1 0.037 14.0 2.9 2.7 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein OS-D PF03392.13 ORX53564.1 - 0.12 12.5 1.4 0.31 11.1 1.4 1.7 1 0 0 1 1 1 0 Insect pheromone-binding family, A10/OS-D HypA PF01155.19 ORX53564.1 - 0.23 11.5 11.8 0.34 11.0 3.6 2.3 1 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 ORX53564.1 - 1.4 9.3 6.0 1.1 9.6 3.5 2.1 2 0 0 2 2 2 0 Restriction alleviation protein Lar Membr_traf_MHD PF10540.9 ORX53565.1 - 2e-19 70.3 1.2 6.2e-10 39.4 0.9 2.8 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 ORX53565.1 - 7.6e-17 61.5 0.0 2.3e-16 60.0 0.0 1.8 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 ORX53565.1 - 9.8e-11 40.9 2.3 2.1e-09 36.5 0.7 2.4 2 0 0 2 2 2 2 Plant family of unknown function (DUF810) Sulfotransfer_4 PF17784.1 ORX53566.1 - 6.4e-60 202.6 0.0 7.4e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ORX53566.1 - 5.6e-05 23.6 0.2 0.0095 16.3 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_4 PF17784.1 ORX53567.1 - 4.2e-55 186.9 0.0 1.9e-54 184.8 0.0 1.8 1 1 0 1 1 1 1 Sulfotransferase domain GPAT_N PF14829.6 ORX53567.1 - 0.014 15.4 0.0 3.7 7.6 0.0 2.6 2 1 0 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal Sulfotransfer_3 PF13469.6 ORX53567.1 - 0.018 15.4 0.1 0.1 13.0 0.0 2.0 1 1 0 2 2 2 0 Sulfotransferase family MatE PF01554.18 ORX53569.1 - 5.5e-50 169.2 30.9 5.5e-27 94.4 10.5 2.6 3 0 0 3 3 3 2 MatE TPR_21 PF09976.9 ORX53571.1 - 0.12 12.1 0.1 0.22 11.2 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain SAM_decarbox PF01536.16 ORX53572.1 - 8.2e-120 400.0 0.0 1.4e-119 399.2 0.0 1.4 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase CRM1_C PF08767.11 ORX53573.1 - 1.1e-119 399.4 4.3 1.8e-119 398.7 0.2 2.8 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 ORX53573.1 - 2.1e-37 128.5 1.9 2.1e-37 128.5 1.9 3.4 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 ORX53573.1 - 2e-32 110.6 4.8 6.2e-32 109.0 4.8 1.9 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 ORX53573.1 - 2.2e-30 104.5 1.6 2.2e-30 104.5 1.6 2.4 2 0 0 2 2 2 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 ORX53573.1 - 1.3e-19 69.4 0.3 3.4e-19 68.1 0.3 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 ORX53573.1 - 1.1e-13 50.9 0.5 1.1e-13 50.9 0.5 2.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain HLH PF00010.26 ORX53574.1 - 3.8e-10 39.6 0.1 9.3e-10 38.3 0.1 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Snf7 PF03357.21 ORX53575.1 - 5.3e-21 75.0 11.4 7.9e-21 74.4 11.4 1.3 1 0 0 1 1 1 1 Snf7 Cwf_Cwc_15 PF04889.12 ORX53575.1 - 3 7.5 9.7 4.7 6.9 9.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Snapin_Pallidin PF14712.6 ORX53575.1 - 4.3 7.8 14.8 3.2 8.2 2.0 3.1 1 1 3 4 4 4 0 Snapin/Pallidin Fzo_mitofusin PF04799.13 ORX53575.1 - 8.6 5.9 8.1 6.3 6.3 0.4 2.7 1 1 2 3 3 3 0 fzo-like conserved region Pro_isomerase PF00160.21 ORX53576.1 - 2.9e-48 164.1 0.2 2.9e-48 164.1 0.2 1.6 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SLC12 PF03522.15 ORX53576.1 - 1.4 7.8 6.4 1.8 7.5 6.4 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PRP38_assoc PF12871.7 ORX53576.1 - 2.2 9.0 73.3 6.8 7.4 51.3 2.4 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Connexin PF00029.19 ORX53576.1 - 5.8 6.6 5.9 8.9 6.0 5.9 1.4 1 0 0 1 1 1 0 Connexin EMP24_GP25L PF01105.24 ORX53579.1 - 5.5e-40 137.2 0.0 6.5e-40 137.0 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD UPRTase PF14681.6 ORX53580.1 - 6.4e-64 215.2 0.0 1.3e-63 214.2 0.0 1.5 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase PRK PF00485.18 ORX53580.1 - 7.3e-61 205.4 0.1 9.9e-61 204.9 0.1 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 ORX53580.1 - 0.00011 22.1 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 ORX53580.1 - 0.00043 20.8 0.2 0.0011 19.6 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX53580.1 - 0.00083 19.8 0.0 0.77 10.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 ORX53580.1 - 0.0023 18.1 0.0 0.0045 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 ORX53580.1 - 0.0029 17.3 0.1 0.48 10.1 0.0 2.2 2 0 0 2 2 2 1 Dephospho-CoA kinase Cytidylate_kin PF02224.18 ORX53580.1 - 0.017 14.9 0.1 5 6.8 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase Tubulin PF00091.25 ORX53580.1 - 0.036 14.3 0.0 0.096 12.9 0.0 1.7 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain Zeta_toxin PF06414.12 ORX53580.1 - 0.041 13.2 0.0 0.083 12.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin RL10P_insert PF17777.1 ORX53580.1 - 0.044 13.8 0.0 0.17 11.9 0.0 2.1 1 0 0 1 1 1 0 Insertion domain in 60S ribosomal protein L10P IML1 PF12257.8 ORX53581.1 - 9.2e-117 389.2 0.0 9.8e-116 385.9 0.1 2.1 2 0 0 2 2 2 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 ORX53581.1 - 2.6e-20 72.3 0.1 7.1e-20 70.8 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PALP PF00291.25 ORX53582.1 - 2.5e-56 191.3 0.1 3.4e-56 190.8 0.1 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ORX53582.1 - 5.3e-14 52.4 0.1 4.8e-08 33.3 0.0 3.4 3 1 1 4 4 4 2 CBS domain TGT PF01702.18 ORX53583.1 - 5e-76 256.1 0.0 5.9e-76 255.9 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Polysacc_deac_1 PF01522.21 ORX53585.1 - 3.6e-28 98.0 0.1 6.3e-28 97.2 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_1 PF01522.21 ORX53586.1 - 8e-27 93.6 0.0 1.5e-26 92.7 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase WD40 PF00400.32 ORX53589.1 - 6.2e-05 23.7 8.7 7.7 7.6 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat DnaJ PF00226.31 ORX53590.1 - 1.2e-17 63.7 0.2 3e-17 62.5 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain EF1_GNE PF00736.19 ORX53591.1 - 2.1e-31 107.9 0.8 2.1e-31 107.9 0.8 2.0 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 ORX53591.1 - 2.2e-12 47.2 1.8 2.2e-12 47.2 1.8 2.5 3 0 0 3 3 3 1 Eukaryotic elongation factor 1 beta central acidic region Polyketide_cyc2 PF10604.9 ORX53591.1 - 0.017 15.4 0.0 0.026 14.8 0.0 1.2 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport DUF3330 PF11809.8 ORX53592.1 - 0.017 15.1 0.0 0.04 14.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) Piwi PF02171.17 ORX53593.1 - 1.4e-105 352.9 0.0 1.9e-105 352.4 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 ORX53593.1 - 1e-21 78.0 0.0 2.1e-21 77.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 ORX53593.1 - 2.1e-20 72.1 0.0 5.5e-20 70.8 0.0 1.8 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 ORX53593.1 - 2.5e-17 62.9 0.3 7e-17 61.5 0.3 1.8 1 0 0 1 1 1 1 Argonaute linker 2 domain PAZ PF02170.22 ORX53593.1 - 1.5e-16 60.5 0.0 2.7e-16 59.6 0.0 1.4 1 0 0 1 1 1 1 PAZ domain ArgoMid PF16487.5 ORX53593.1 - 1.5e-10 41.2 0.3 7.2e-10 39.0 0.0 2.4 3 0 0 3 3 3 1 Mid domain of argonaute E1-E2_ATPase PF00122.20 ORX53594.1 - 6.9e-32 110.4 0.4 6.9e-32 110.4 0.4 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX53594.1 - 5.4e-26 91.4 5.4 5.4e-26 91.4 5.4 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX53594.1 - 9.6e-17 60.9 0.0 1.8e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX53594.1 - 2.3e-14 54.2 2.2 2.2e-13 51.0 0.6 2.7 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX53594.1 - 2.9e-10 39.7 0.0 7.5e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX53594.1 - 0.00028 20.7 0.3 0.00081 19.2 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF4870 PF09685.10 ORX53594.1 - 7.6 6.7 8.9 0.98 9.6 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4870) PI31_Prot_N PF11566.8 ORX53596.1 - 3e-41 140.9 0.0 4e-41 140.5 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 ORX53596.1 - 8.6e-13 49.3 15.5 2.4e-12 47.8 14.7 2.3 1 1 0 1 1 1 1 PI31 proteasome regulator UPF0052 PF01933.18 ORX53597.1 - 3e-52 177.7 0.0 6.8e-52 176.5 0.0 1.5 2 0 0 2 2 2 1 Uncharacterised protein family UPF0052 COPIIcoated_ERV PF07970.12 ORX53598.1 - 1.7e-54 185.0 0.0 2.7e-54 184.3 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ORX53598.1 - 2.4e-29 101.5 0.0 3.8e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) COPIIcoated_ERV PF07970.12 ORX53599.1 - 7.4e-09 35.8 0.1 8.4e-09 35.6 0.1 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter LMWPc PF01451.21 ORX53600.1 - 1.5e-17 64.3 0.1 2.6e-17 63.5 0.1 1.4 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Guanylate_kin PF00625.21 ORX53600.1 - 0.045 13.4 0.0 0.076 12.7 0.0 1.3 1 1 0 1 1 1 0 Guanylate kinase FlpD PF02662.16 ORX53600.1 - 0.062 13.3 0.0 0.34 10.9 0.0 2.2 1 1 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit SBF PF01758.16 ORX53601.1 - 2.8e-52 177.3 14.6 7e-52 175.9 14.6 1.7 1 0 0 1 1 1 1 Sodium Bile acid symporter family Stevor PF17410.2 ORX53601.1 - 0.51 9.8 1.1 0.92 9.0 1.1 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF3464 PF11947.8 ORX53601.1 - 7.7 6.3 5.9 2 8.2 0.2 2.7 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 Pkinase PF00069.25 ORX53602.1 - 5e-56 190.0 0.0 9.5e-56 189.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53602.1 - 2e-44 151.8 0.0 1.3e-43 149.2 0.0 2.2 3 0 0 3 3 3 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX53602.1 - 5.2e-07 28.8 0.0 1.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX53602.1 - 0.0013 18.1 0.0 0.0075 15.6 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX53602.1 - 0.035 13.1 0.0 0.15 11.0 0.0 2.1 1 1 0 1 1 1 0 Haspin like kinase domain C2 PF00168.30 ORX53603.1 - 0.0027 18.0 0.0 3.2 8.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain G-gamma PF00631.22 ORX53604.1 - 2.7e-21 75.3 0.0 3.1e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 GGL domain Aconitase PF00330.20 ORX53605.1 - 4.4e-111 372.1 0.0 3.9e-110 369.0 0.0 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX53605.1 - 7.4e-21 74.8 0.0 1.4e-20 73.9 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 ORX53605.1 - 0.0077 15.0 0.0 0.012 14.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF521) Ins134_P3_kin PF05770.11 ORX53606.1 - 7.1e-30 104.0 0.0 1.4e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Ins134_P3_kin_N PF17927.1 ORX53606.1 - 1.6e-11 44.4 0.1 3.6e-11 43.3 0.1 1.6 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain ATP-grasp PF02222.22 ORX53606.1 - 8.3e-05 22.2 0.0 0.00015 21.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Methyltransf_16 PF10294.9 ORX53607.1 - 5.3e-16 58.8 0.0 6.9e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 ORX53607.1 - 3.9e-05 23.5 0.0 5.3e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53607.1 - 0.00033 21.3 0.0 0.0011 19.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX53607.1 - 0.0037 16.7 0.0 0.005 16.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ORX53607.1 - 0.0063 17.2 0.0 0.013 16.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ORX53607.1 - 0.01 15.0 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_11 PF08241.12 ORX53607.1 - 0.013 16.1 0.0 0.026 15.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 ORX53607.1 - 0.19 11.0 0.0 0.29 10.4 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Tropomyosin_1 PF12718.7 ORX53608.1 - 1.5e-27 96.5 32.6 1.5e-27 96.5 32.6 2.3 2 0 0 2 2 2 1 Tropomyosin like DnaJ-X PF14308.6 ORX53608.1 - 2.5e-26 92.4 0.1 2.5e-26 92.4 0.1 3.4 2 2 0 2 2 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 ORX53608.1 - 1.4e-11 44.4 0.1 5.9e-11 42.3 0.1 2.1 1 0 0 1 1 1 1 DnaJ domain Tropomyosin PF00261.20 ORX53608.1 - 0.003 17.0 14.9 0.003 17.0 14.9 3.1 2 1 1 3 3 3 2 Tropomyosin LANC_like PF05147.13 ORX53608.1 - 0.031 12.9 0.5 0.075 11.6 0.2 1.8 2 1 0 2 2 2 0 Lanthionine synthetase C-like protein DUF1664 PF07889.12 ORX53608.1 - 0.43 10.6 13.1 0.081 13.0 5.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ALMT PF11744.8 ORX53608.1 - 1.3 7.8 11.4 1.6 7.5 9.7 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter Mito_fiss_reg PF05308.11 ORX53608.1 - 3 7.8 9.7 0.64 10.1 5.0 2.0 1 1 1 2 2 2 0 Mitochondrial fission regulator Cep57_CLD PF14073.6 ORX53608.1 - 4.8 7.2 34.3 0.54 10.3 14.7 3.0 2 1 1 3 3 3 0 Centrosome localisation domain of Cep57 Nup88 PF10168.9 ORX53608.1 - 7.2 4.3 23.1 6.8 4.4 0.0 2.3 2 0 0 2 2 2 0 Nuclear pore component HOOK PF05622.12 ORX53608.1 - 9.5 4.2 32.5 0.2 9.8 25.8 1.4 2 0 0 2 2 2 0 HOOK protein VMA21 PF09446.10 ORX53610.1 - 6.6e-12 45.4 9.2 9.2e-12 44.9 9.2 1.2 1 0 0 1 1 1 1 VMA21-like domain DUF1129 PF06570.11 ORX53610.1 - 0.00095 18.7 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) HLH PF00010.26 ORX53611.1 - 6.8e-12 45.2 2.6 6.8e-12 45.2 2.6 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain HSP90 PF00183.18 ORX53611.1 - 0.0042 16.0 1.5 0.0046 15.9 1.5 1.0 1 0 0 1 1 1 1 Hsp90 protein PhoU_div PF01865.16 ORX53611.1 - 0.0077 15.6 0.2 0.0092 15.3 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF47 Takusan PF04822.13 ORX53611.1 - 0.0088 15.9 2.9 0.011 15.6 2.1 1.6 1 1 0 1 1 1 1 Takusan NRBF2 PF08961.10 ORX53611.1 - 0.026 14.2 1.5 0.029 14.0 1.5 1.2 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 ORX53611.1 - 0.026 15.2 3.5 0.026 15.2 3.5 2.0 1 1 1 2 2 2 0 Initiation control protein YabA PPR_3 PF13812.6 ORX53612.1 - 6.7e-49 163.8 4.5 1.3e-12 47.5 0.2 6.8 6 2 0 7 7 7 6 Pentatricopeptide repeat domain PPR_2 PF13041.6 ORX53612.1 - 2.9e-37 126.6 7.1 4.3e-10 39.6 0.0 8.4 6 4 4 10 10 10 7 PPR repeat family PPR_long PF17177.4 ORX53612.1 - 5.5e-28 97.8 8.0 2.1e-11 43.6 0.1 3.7 1 1 3 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ORX53612.1 - 4.9e-19 67.2 6.1 1.3e-05 25.1 0.0 9.9 12 0 0 12 12 11 3 PPR repeat PPR_1 PF12854.7 ORX53612.1 - 1.2e-11 44.1 5.4 0.00039 20.1 0.0 8.0 8 0 0 8 8 8 1 PPR repeat TPR_14 PF13428.6 ORX53612.1 - 0.00068 20.3 0.0 0.14 13.1 0.0 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat MRP-S27 PF10037.9 ORX53612.1 - 0.021 13.7 0.4 0.78 8.5 0.1 2.5 3 0 0 3 3 3 0 Mitochondrial 28S ribosomal protein S27 MNE1 PF13762.6 ORX53612.1 - 0.025 14.6 0.2 0.18 11.8 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial splicing apparatus component RPM2 PF08579.11 ORX53612.1 - 0.042 14.2 1.0 21 5.5 0.2 4.2 3 2 1 4 4 4 0 Mitochondrial ribonuclease P subunit (RPM2) RPN7 PF10602.9 ORX53612.1 - 0.12 12.0 3.6 0.56 9.9 0.5 3.4 3 2 1 4 4 4 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 ORX53612.1 - 0.33 11.5 1.5 2.3 8.8 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX53612.1 - 0.71 10.2 2.6 4.5 7.6 0.0 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat Endonuc_Holl PF10107.9 ORX53613.1 - 0.13 12.2 3.0 0.18 11.7 0.6 2.0 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase zf-C2H2 PF00096.26 ORX53614.1 - 6.3e-16 57.9 14.3 5.3e-07 29.7 0.1 3.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX53614.1 - 8.8e-12 44.8 14.2 0.00057 20.5 0.2 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX53614.1 - 3.7e-11 42.9 15.0 1.4e-05 25.3 0.2 3.6 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX53614.1 - 1.6e-06 27.9 5.7 0.11 12.5 0.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX53614.1 - 4.6e-05 23.6 1.2 1.3 9.4 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 ORX53614.1 - 0.0013 18.3 4.9 0.33 10.6 0.3 3.3 3 1 0 3 3 3 1 Ubiquitin-Binding Zinc Finger zf_ZIC PF18366.1 ORX53614.1 - 0.0027 17.8 3.7 1.3 9.2 0.0 3.1 2 1 1 3 3 3 1 Zic proteins zinc finger domain zf-C2H2_8 PF15909.5 ORX53614.1 - 0.0065 16.7 0.7 0.0065 16.7 0.7 1.9 1 1 0 1 1 1 1 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 ORX53614.1 - 0.0079 16.3 1.1 1.3 9.2 0.2 2.5 2 1 0 2 2 2 1 Zinc ribbon domain zf-met PF12874.7 ORX53614.1 - 0.012 16.0 4.8 1.4 9.4 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger of C2H2 type C1_4 PF07975.12 ORX53614.1 - 0.015 15.5 3.7 0.11 12.7 0.2 2.1 1 1 1 2 2 2 0 TFIIH C1-like domain ADK_lid PF05191.14 ORX53614.1 - 0.053 13.5 3.7 0.48 10.5 0.9 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF2256 PF10013.9 ORX53614.1 - 0.11 12.7 4.4 0.9 9.7 0.1 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_11 PF16622.5 ORX53614.1 - 0.23 11.3 9.9 7.6 6.4 0.1 3.2 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-CHY PF05495.12 ORX53614.1 - 0.24 11.9 4.9 0.65 10.5 3.2 2.1 1 1 0 1 1 1 0 CHY zinc finger zf-RRN7 PF11781.8 ORX53614.1 - 0.41 10.4 5.9 0.58 9.9 0.3 2.8 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-C2HC_2 PF13913.6 ORX53614.1 - 0.68 9.9 20.5 0.46 10.5 0.7 3.9 4 1 0 4 4 3 0 zinc-finger of a C2HC-type Zn_ribbon_recom PF13408.6 ORX53614.1 - 1.1 9.8 4.7 1.3 9.6 1.9 2.3 2 1 1 3 3 3 0 Recombinase zinc beta ribbon domain HNH PF01844.23 ORX53614.1 - 1.2 9.4 6.1 8.1 6.7 0.2 3.0 3 0 0 3 3 3 0 HNH endonuclease zf-AN1 PF01428.16 ORX53614.1 - 4 7.7 11.3 19 5.5 1.6 2.9 1 1 1 2 2 2 0 AN1-like Zinc finger FAT PF02259.23 ORX53615.1 - 3.1e-124 414.7 1.8 3.1e-124 414.7 1.8 1.9 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 ORX53615.1 - 5.9e-73 245.8 0.2 1.3e-72 244.7 0.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 ORX53615.1 - 1.4e-63 213.6 6.5 6.2e-59 198.5 0.1 5.5 5 1 1 6 6 4 1 Domain of unknown function (DUF3385) FRB_dom PF08771.11 ORX53615.1 - 2.6e-45 152.9 0.7 2.2e-44 149.9 0.7 2.8 1 0 0 1 1 1 1 FKBP12-rapamycin binding domain FATC PF02260.20 ORX53615.1 - 4.1e-17 61.7 1.0 1.2e-16 60.2 1.0 1.9 1 0 0 1 1 1 1 FATC domain HEAT PF02985.22 ORX53615.1 - 5.5e-15 54.2 16.7 0.04 14.2 0.0 10.7 10 0 0 10 10 9 4 HEAT repeat HEAT_2 PF13646.6 ORX53615.1 - 2.2e-13 50.4 16.5 0.24 11.8 0.0 10.3 8 2 4 12 12 12 4 HEAT repeats HEAT_EZ PF13513.6 ORX53615.1 - 3.4e-10 40.2 28.2 0.0008 19.9 0.2 11.7 12 3 3 15 15 12 3 HEAT-like repeat Cnd1 PF12717.7 ORX53615.1 - 1e-08 35.4 2.3 0.01 15.9 0.0 6.5 5 1 2 7 7 6 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ORX53615.1 - 1.3e-06 27.3 8.2 0.0011 17.6 0.5 4.9 4 1 0 4 4 4 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX53615.1 - 1.4e-06 28.8 0.9 18 6.0 0.0 7.3 7 1 1 8 8 7 0 Vacuolar 14 Fab1-binding region Sec7_N PF12783.7 ORX53615.1 - 2e-06 27.8 0.4 0.13 12.1 0.0 5.2 3 1 1 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_19 PF14559.6 ORX53615.1 - 4.1e-06 27.2 0.5 0.085 13.4 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53615.1 - 0.00012 22.6 2.2 0.55 10.9 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat CLASP_N PF12348.8 ORX53615.1 - 0.00017 21.3 0.6 0.59 9.6 0.0 5.2 5 1 0 5 5 5 1 CLASP N terminal Tti2 PF10521.9 ORX53615.1 - 0.00096 18.8 4.5 0.54 9.8 0.0 4.9 3 1 2 5 5 5 1 Tti2 family MMS19_C PF12460.8 ORX53615.1 - 0.0011 18.2 4.3 1.2 8.1 0.1 4.4 4 0 0 4 4 4 1 RNAPII transcription regulator C-terminal Arm PF00514.23 ORX53615.1 - 0.0019 18.2 0.3 55 4.0 0.0 5.9 6 0 0 6 6 4 0 Armadillo/beta-catenin-like repeat T_hemolysin PF12261.8 ORX53615.1 - 0.015 15.0 0.0 0.12 12.1 0.0 2.5 2 0 0 2 2 2 0 Thermostable hemolysin ANAPC3 PF12895.7 ORX53615.1 - 0.018 15.3 0.3 14 5.9 0.0 3.9 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 ParcG PF10274.9 ORX53615.1 - 0.32 11.1 2.3 13 5.9 0.1 3.9 3 1 1 4 4 4 0 Parkin co-regulated protein TPR_7 PF13176.6 ORX53615.1 - 0.78 9.9 4.6 69 3.8 0.3 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX53615.1 - 2.4 9.2 6.0 4.9 8.2 0.1 4.7 5 0 0 5 5 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX53615.1 - 2.9 8.2 6.0 51 4.3 0.8 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat KCH PF16944.5 ORX53616.1 - 2.4e-78 263.4 12.9 2.8e-78 263.2 12.9 1.1 1 0 0 1 1 1 1 Fungal potassium channel MMM1 PF10296.9 ORX53617.1 - 6.8e-12 45.1 1.4 1.6e-09 37.3 0.5 2.5 2 1 0 2 2 2 2 Maintenance of mitochondrial morphology protein 1 Flg_hook PF02120.16 ORX53618.1 - 0.043 13.7 3.0 0.066 13.1 0.1 2.8 3 1 0 3 3 3 0 Flagellar hook-length control protein FliK Takusan PF04822.13 ORX53618.1 - 0.74 9.7 10.6 2.3 8.2 0.3 4.2 4 0 0 4 4 4 0 Takusan DUF4164 PF13747.6 ORX53618.1 - 6.1 7.2 8.2 2.8 8.3 0.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Ribosomal_S4e PF00900.20 ORX53619.1 - 3.4e-38 129.4 0.5 3.4e-38 129.4 0.5 2.4 3 0 0 3 3 3 1 Ribosomal family S4e 40S_S4_C PF16121.5 ORX53619.1 - 1.9e-26 91.5 0.1 3.5e-26 90.6 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 ORX53619.1 - 6.2e-19 67.8 6.2 1.3e-18 66.8 6.2 1.6 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 ORX53619.1 - 3.6e-06 26.7 5.9 9.9e-06 25.3 4.9 2.3 2 0 0 2 2 2 1 KOW motif S4 PF01479.25 ORX53619.1 - 5.3e-06 26.1 0.0 1.3e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 S4 domain Sipho_tail PF05709.11 ORX53619.1 - 0.074 12.5 0.3 0.13 11.7 0.3 1.4 1 1 0 1 1 1 0 Phage tail protein Metallophos PF00149.28 ORX53621.1 - 7.8e-36 124.5 0.3 1.7e-35 123.4 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX53621.1 - 2.6e-16 59.8 0.1 4.8e-16 58.9 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain zf-C2H2 PF00096.26 ORX53622.1 - 9.9e-08 32.0 15.0 5.2e-05 23.5 5.1 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX53622.1 - 2.2e-07 31.0 18.2 1.1e-06 28.8 7.5 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX53622.1 - 0.00041 20.9 13.1 0.0072 17.1 3.6 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX53622.1 - 0.0088 16.3 1.3 0.0088 16.3 1.3 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX53622.1 - 0.17 11.7 9.9 0.46 10.3 2.1 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 ORX53622.1 - 1 9.5 9.6 2.1 8.6 8.3 2.0 1 1 1 2 2 2 0 Zinc ribbon domain RPN1_RPN2_N PF17781.1 ORX53624.1 - 8.5e-121 403.1 0.4 1.3e-120 402.5 0.4 1.3 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain PC_rep PF01851.22 ORX53624.1 - 2.9e-32 109.5 21.3 6.4e-08 32.7 0.2 8.4 9 0 0 9 9 9 7 Proteasome/cyclosome repeat RPN1_C PF18051.1 ORX53624.1 - 7.9e-32 109.1 0.1 1.4e-31 108.3 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal HEAT_2 PF13646.6 ORX53624.1 - 4.4e-08 33.4 3.4 0.034 14.5 0.1 4.4 4 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 ORX53624.1 - 0.022 15.0 0.0 11 6.6 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat DUF2776 PF10951.8 ORX53624.1 - 0.029 13.6 0.0 0.053 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2776) Smr PF01713.21 ORX53625.1 - 6e-10 39.3 0.0 2.4e-09 37.4 0.0 2.0 2 0 0 2 2 2 1 Smr domain DUF1771 PF08590.10 ORX53625.1 - 0.00023 21.5 0.7 0.00086 19.6 0.7 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) CUE PF02845.16 ORX53625.1 - 0.022 14.4 0.1 0.071 12.8 0.1 2.0 1 0 0 1 1 1 0 CUE domain Helicase_IV_N PF12462.8 ORX53625.1 - 0.079 12.9 0.6 0.19 11.7 0.1 1.9 2 0 0 2 2 2 0 DNA helicase IV / RNA helicase N terminal Zip PF02535.22 ORX53626.1 - 1.9e-37 129.3 3.0 2.3e-37 129.0 3.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter PGM_PMM_I PF02878.16 ORX53627.1 - 1.1e-19 70.5 0.0 1.7e-08 34.2 0.0 3.0 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 ORX53627.1 - 1.7e-11 44.1 0.6 5.2e-11 42.6 0.6 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 ORX53627.1 - 3.3e-05 24.4 0.1 0.00036 21.1 0.0 2.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ORX53627.1 - 0.081 13.1 0.3 0.23 11.7 0.3 1.9 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III DUF4132 PF13569.6 ORX53627.1 - 0.15 11.8 0.1 1.4 8.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4132) NCA2 PF08637.10 ORX53628.1 - 1.6e-63 214.6 1.6 7.7e-36 123.7 0.0 2.6 3 0 0 3 3 3 2 ATP synthase regulation protein NCA2 SOAR PF16533.5 ORX53628.1 - 0.27 11.2 2.0 0.48 10.4 0.3 2.2 2 1 1 3 3 3 0 STIM1 Orai1-activating region Elf1 PF05129.13 ORX53630.1 - 3.7e-23 81.4 8.0 2e-16 59.8 5.9 2.2 2 0 0 2 2 2 2 Transcription elongation factor Elf1 like mRNA_cap_enzyme PF01331.19 ORX53631.1 - 0.0019 18.1 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain Ribosomal_L13 PF00572.18 ORX53632.1 - 9e-10 38.9 0.0 8.2e-08 32.5 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein L13 DUF1629 PF07791.11 ORX53632.1 - 0.094 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1629) Enkurin PF13864.6 ORX53633.1 - 7.5e-05 23.1 0.2 7.5e-05 23.1 0.2 4.3 3 1 1 4 4 4 1 Calmodulin-binding PfUIS3 PF11567.8 ORX53633.1 - 0.03 14.7 0.4 0.03 14.7 0.4 2.2 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein CENP-F_leu_zip PF10473.9 ORX53633.1 - 0.036 14.1 33.9 0.54 10.3 7.3 3.7 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2125 PF09898.9 ORX53633.1 - 0.097 12.3 1.0 0.18 11.4 1.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2125) PKcGMP_CC PF16808.5 ORX53633.1 - 0.17 11.8 0.2 0.17 11.8 0.2 4.7 6 0 0 6 6 6 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 ORX53633.1 - 0.31 10.3 13.1 3 7.1 13.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3037 PF11236.8 ORX53633.1 - 0.53 10.7 3.3 4.1 7.8 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) UPF0242 PF06785.11 ORX53633.1 - 0.73 9.9 31.6 0.25 11.4 4.8 3.3 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 ORX53633.1 - 8.5 6.9 17.2 1.3 9.4 0.2 5.1 4 1 2 6 6 6 0 Flagella accessory protein C (FlaC) Atg14 PF10186.9 ORX53633.1 - 8.5 5.4 25.5 0.73 8.9 7.7 3.4 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Velvet PF11754.8 ORX53634.1 - 1.8e-61 208.3 3.9 7.4e-39 134.2 0.7 3.3 2 2 1 3 3 3 2 Velvet factor Phage_Coat_A PF05357.13 ORX53634.1 - 8.8 6.2 6.3 2.1 8.2 0.1 2.9 3 0 0 3 3 3 0 Phage Coat Protein A Ribosomal_L22 PF00237.19 ORX53636.1 - 1.9e-38 130.8 0.2 2.7e-38 130.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e CUTL PF16557.5 ORX53636.1 - 0.14 12.3 0.9 0.53 10.5 0.1 2.2 2 1 0 2 2 2 0 CUT1-like DNA-binding domain of SATB Rdx PF10262.9 ORX53637.1 - 1.3e-30 105.4 0.0 1.6e-30 105.1 0.0 1.1 1 0 0 1 1 1 1 Rdx family SIR2 PF02146.17 ORX53640.1 - 1.3e-37 129.5 0.0 2.5e-37 128.5 0.0 1.5 2 0 0 2 2 2 1 Sir2 family TPP_enzyme_M PF00205.22 ORX53640.1 - 0.0064 16.2 0.0 2 8.2 0.0 2.4 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain TPR_11 PF13414.6 ORX53641.1 - 9.7e-13 47.6 0.1 5.6e-06 25.9 0.1 3.4 3 0 0 3 3 3 2 TPR repeat TPR_2 PF07719.17 ORX53641.1 - 1.1e-11 43.9 1.4 0.13 12.4 0.1 5.0 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53641.1 - 4.4e-11 42.1 0.7 0.33 10.9 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX53641.1 - 1.3e-08 35.2 8.1 3.4e-05 24.3 0.7 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX53641.1 - 8.3e-07 29.0 0.4 0.00053 20.2 0.4 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX53641.1 - 1.2e-06 28.8 5.9 0.27 12.2 0.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX53641.1 - 5.1e-06 26.6 8.3 0.012 15.7 0.4 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX53641.1 - 1.5e-05 25.5 6.1 0.021 15.5 0.5 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX53641.1 - 2.9e-05 24.3 5.4 0.011 16.0 1.5 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX53641.1 - 5.4e-05 22.7 8.3 0.00088 18.7 0.5 2.9 2 1 1 3 3 3 2 MalT-like TPR region TPR_8 PF13181.6 ORX53641.1 - 0.00097 19.2 0.1 2.8 8.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX53641.1 - 0.027 14.5 0.5 24 5.2 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ORX53641.1 - 0.033 13.4 4.0 0.45 9.7 0.3 2.6 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ORX53641.1 - 0.04 14.2 3.8 0.064 13.6 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX53641.1 - 0.46 11.2 3.7 69 4.4 0.1 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat Sugar_tr PF00083.24 ORX53642.1 - 2.1e-46 158.8 28.9 7.1e-27 94.4 7.8 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX53642.1 - 1.5e-18 66.9 39.3 7.7e-10 38.2 19.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MOZ_SAS PF01853.18 ORX53643.1 - 4.7e-83 277.2 0.3 9.3e-83 276.3 0.3 1.5 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ORX53643.1 - 4e-21 74.4 3.3 4e-21 74.4 3.3 2.2 2 0 0 2 2 2 1 MYST family zinc finger domain PHD PF00628.29 ORX53643.1 - 1.1e-12 47.7 29.2 2.4e-07 30.5 9.7 3.3 2 1 1 3 3 3 2 PHD-finger Acetyltransf_7 PF13508.7 ORX53643.1 - 0.017 15.6 0.0 0.034 14.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain C1_1 PF00130.22 ORX53643.1 - 3.9 7.4 28.2 0.13 12.1 0.4 3.7 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) ArAE_2 PF10334.9 ORX53644.1 - 2.3e-17 63.6 0.1 4.6e-17 62.6 0.1 1.5 1 0 0 1 1 1 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 ORX53644.1 - 2.8e-14 53.3 16.7 2.8e-14 53.3 16.7 2.5 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2_N PF10337.9 ORX53644.1 - 4.7e-05 22.6 0.5 4.7e-05 22.6 0.5 3.1 2 1 1 3 3 3 2 Putative ER transporter, 6TM, N-terminal FUSC PF04632.12 ORX53644.1 - 0.00012 20.8 4.7 0.00012 20.8 4.7 2.3 2 0 0 2 2 2 1 Fusaric acid resistance protein family NYAP_C PF15452.6 ORX53644.1 - 0.19 11.6 5.0 1.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter ALMT PF11744.8 ORX53644.1 - 2.8 6.7 14.6 0.041 12.7 6.1 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter Kelch_1 PF01344.25 ORX53646.1 - 7.9e-14 51.0 5.6 0.00037 20.0 0.0 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ORX53646.1 - 1.2e-13 50.7 8.1 2.1e-05 24.4 0.2 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ORX53646.1 - 8.3e-13 48.1 11.6 0.0031 17.5 0.0 6.1 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX53646.1 - 1.4e-11 44.2 12.6 0.014 15.7 0.0 6.6 6 1 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ORX53646.1 - 1.2e-09 37.8 2.2 0.13 12.2 0.0 6.0 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ORX53646.1 - 4e-08 33.3 18.1 0.56 10.6 0.2 6.8 6 1 0 6 6 6 4 Galactose oxidase, central domain VSP PF03302.13 ORX53646.1 - 0.0087 15.0 3.3 0.021 13.7 3.3 1.6 1 0 0 1 1 1 1 Giardia variant-specific surface protein SKG6 PF08693.10 ORX53646.1 - 0.037 13.4 3.1 0.11 11.9 3.1 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain YqhR PF11085.8 ORX53646.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.6 3 0 0 3 3 3 0 Conserved membrane protein YqhR RrnaAD PF00398.20 ORX53647.1 - 1.2e-20 73.7 0.0 1.3e-20 73.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Ribosomal_S14 PF00253.21 ORX53649.1 - 1.7e-23 82.1 0.3 9.2e-23 79.8 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e HAT PF02184.16 ORX53650.1 - 6.5e-32 109.2 63.6 1.2e-16 60.3 0.7 14.2 16 1 0 16 16 16 7 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ORX53650.1 - 4.1e-23 80.1 7.6 0.00037 21.1 0.1 10.1 9 3 4 13 13 11 5 Tetratricopeptide repeat Suf PF05843.14 ORX53650.1 - 1.2e-20 74.7 24.4 3e-06 27.4 0.9 7.2 2 1 4 7 7 7 6 Suppressor of forked protein (Suf) TPR_19 PF14559.6 ORX53650.1 - 7.8e-15 55.1 0.0 0.0019 18.7 0.0 7.3 7 2 3 10 10 9 4 Tetratricopeptide repeat TPR_17 PF13431.6 ORX53650.1 - 6.4e-09 35.6 2.0 0.00012 22.2 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX53650.1 - 4.7e-07 30.0 8.2 4.5 8.1 0.0 9.5 12 0 0 12 12 12 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ORX53650.1 - 4e-06 26.8 22.7 0.0083 16.1 2.5 7.2 5 2 1 6 6 6 2 Mad3/BUB1 homology region 1 BSD PF03909.17 ORX53650.1 - 0.00031 20.7 1.0 0.031 14.3 0.0 3.4 3 0 0 3 3 3 1 BSD domain TPR_2 PF07719.17 ORX53650.1 - 0.0011 19.0 12.9 3.9 7.8 0.0 8.2 11 0 0 11 11 9 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 ORX53650.1 - 0.052 13.6 20.7 0.26 11.4 0.9 6.7 5 2 2 7 7 7 0 U3 small nucleolar RNA-associated protein 6 Fis1_TPR_C PF14853.6 ORX53650.1 - 0.27 11.3 5.0 33 4.6 0.0 5.1 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_12 PF13424.6 ORX53650.1 - 0.8 10.0 12.4 4.7 7.6 0.0 5.9 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX53650.1 - 9.1 6.3 7.4 16 5.5 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat PX PF00787.24 ORX53651.1 - 2.1e-20 72.8 0.4 9e-20 70.8 0.1 2.2 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 ORX53651.1 - 4.2e-15 56.0 7.8 3.1e-08 33.5 2.0 2.1 2 0 0 2 2 2 2 Vps5 C terminal like BAR_3 PF16746.5 ORX53651.1 - 0.012 15.3 7.6 0.032 13.9 0.2 2.4 2 1 0 2 2 2 0 BAR domain of APPL family Cytochrom_B562 PF07361.11 ORX53651.1 - 0.45 11.2 4.2 8.1 7.2 0.0 3.2 3 0 0 3 3 3 0 Cytochrome b562 ATG22 PF11700.8 ORX53652.1 - 3.1e-99 332.8 23.0 3.9e-99 332.5 23.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ORX53652.1 - 1.8e-09 37.0 45.3 6.3e-05 22.1 15.1 3.0 1 1 1 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX53652.1 - 9.6 4.3 17.6 1.3 7.2 10.4 2.7 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family ATG22 PF11700.8 ORX53653.1 - 1.2e-55 189.1 12.8 1.4e-55 188.9 12.8 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like Phage_glycop_gL PF11108.8 ORX53653.1 - 0.03 14.4 0.0 0.054 13.5 0.0 1.3 1 0 0 1 1 1 0 Viral glycoprotein L DUF2023 PF09633.10 ORX53653.1 - 0.036 14.2 0.1 0.066 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2023) YrhC PF14143.6 ORX53653.1 - 0.081 13.0 4.7 6 7.0 1.2 3.0 2 0 0 2 2 2 0 YrhC-like protein SUR7 PF06687.12 ORX53653.1 - 5.6 6.5 14.0 0.072 12.7 1.8 2.9 2 1 1 3 3 3 0 SUR7/PalI family PI-PLC-X PF00388.19 ORX53654.1 - 0.064 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain PAP_central PF04928.17 ORX53655.1 - 9.9e-113 375.2 0.0 1.3e-112 374.8 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ORX53655.1 - 1.5e-30 106.1 0.1 7.6e-30 103.8 0.1 2.1 1 1 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ORX53655.1 - 1.4e-10 41.3 0.0 4.1e-10 39.8 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ORX53655.1 - 0.024 14.4 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain WD40 PF00400.32 ORX53656.1 - 1.6e-20 73.0 15.2 0.00014 22.5 0.2 7.8 8 0 0 8 8 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX53656.1 - 2.2e-13 50.3 0.2 0.035 14.4 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 PF13923.6 ORX53656.1 - 2.6e-09 36.8 9.6 7.6e-09 35.3 9.6 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX53656.1 - 3.9e-08 33.0 5.3 3.9e-08 33.0 5.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX53656.1 - 6.1e-08 32.4 9.3 6.1e-08 32.4 9.3 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX53656.1 - 1.1e-07 31.7 5.3 1.4e-07 31.5 3.4 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ORX53656.1 - 1.2e-07 31.9 8.8 3.4e-07 30.5 8.8 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 ORX53656.1 - 1.3e-05 25.3 9.4 3.3e-05 23.9 9.4 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ORX53656.1 - 2.6e-05 24.1 8.4 2.6e-05 24.1 8.4 2.2 2 0 0 2 2 2 1 zinc-RING finger domain WD40_like PF17005.5 ORX53656.1 - 3.8e-05 23.2 0.0 0.0059 16.0 0.0 3.0 2 1 1 3 3 3 1 WD40-like domain U-box PF04564.15 ORX53656.1 - 0.00028 21.0 1.2 0.0023 18.1 0.0 2.9 3 0 0 3 3 3 1 U-box domain zf-rbx1 PF12678.7 ORX53656.1 - 0.00052 20.2 3.7 0.00052 20.2 3.7 2.2 2 0 0 2 2 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ORX53656.1 - 0.0014 18.4 7.0 0.037 13.9 7.8 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 Menin PF05053.13 ORX53656.1 - 0.02 13.3 0.1 0.029 12.7 0.1 1.1 1 0 0 1 1 1 0 Menin DUF4451 PF14616.6 ORX53656.1 - 0.065 13.4 0.6 42 4.4 0.0 3.6 3 1 0 4 4 4 0 Domain of unknown function (DUF4451) zf-RING_10 PF16685.5 ORX53656.1 - 0.11 12.7 2.7 0.67 10.1 2.9 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.11 ORX53656.1 - 3.2 7.7 5.9 1.2 9.1 1.9 2.2 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) TLD PF07534.16 ORX53657.1 - 1.8e-33 115.7 0.1 2.4e-33 115.3 0.1 1.2 1 0 0 1 1 1 1 TLD G6PD_C PF02781.16 ORX53661.1 - 6.8e-110 366.8 0.0 9.4e-110 366.4 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ORX53661.1 - 4.4e-53 180.5 0.0 3.1e-52 177.8 0.0 2.0 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain KNTase_C PF07827.11 ORX53661.1 - 0.17 11.7 0.0 25 4.7 0.0 2.3 2 0 0 2 2 2 0 KNTase C-terminal domain OPT PF03169.15 ORX53662.1 - 2.4e-157 525.3 50.5 2.7e-157 525.1 50.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Elongin_A PF06881.11 ORX53663.1 - 3.1e-23 82.3 1.5 6.1e-23 81.3 1.5 1.5 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A EBP50_C PF09007.11 ORX53663.1 - 6.1 7.9 9.5 0.64 11.0 4.0 2.0 1 1 1 2 2 2 0 EBP50, C-terminal Myosin_head PF00063.21 ORX53664.1 - 5.5e-243 808.1 1.1 6.9e-243 807.8 1.1 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ORX53664.1 - 1.5e-45 155.2 0.2 2.6e-45 154.4 0.2 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_9 PF14604.6 ORX53664.1 - 4.8e-15 55.1 0.1 1.1e-14 54.0 0.1 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX53664.1 - 4.9e-14 51.7 0.9 9.3e-14 50.8 0.9 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX53664.1 - 1.2e-10 40.9 0.0 3.1e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX53664.1 - 0.00028 21.1 0.3 0.00063 20.0 0.3 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain Hpr_kinase_C PF07475.12 ORX53664.1 - 0.01 15.4 0.5 3.7 7.0 0.1 2.4 2 0 0 2 2 2 2 HPr Serine kinase C-terminal domain IQ PF00612.27 ORX53664.1 - 0.02 14.7 4.6 1.2 9.1 0.3 2.9 1 1 1 2 2 2 0 IQ calmodulin-binding motif AAA_16 PF13191.6 ORX53664.1 - 0.023 15.1 0.0 0.074 13.4 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX53664.1 - 0.044 14.1 0.0 0.14 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX53664.1 - 0.19 11.7 0.1 0.4 10.6 0.1 1.5 1 0 0 1 1 1 0 NACHT domain Cpn60_TCP1 PF00118.24 ORX53666.1 - 7.6e-149 496.5 11.1 8.5e-149 496.3 11.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 ORX53666.1 - 0.0012 18.4 0.0 0.0025 17.4 0.0 1.4 1 0 0 1 1 1 1 EAL domain Nitro_FeMo-Co PF02579.17 ORX53666.1 - 0.052 13.9 0.5 0.74 10.2 0.0 3.0 4 0 0 4 4 4 0 Dinitrogenase iron-molybdenum cofactor PrpR_N PF06506.11 ORX53666.1 - 0.063 12.9 0.6 0.24 11.0 0.1 2.1 2 0 0 2 2 2 0 Propionate catabolism activator DrsE PF02635.15 ORX53666.1 - 0.1 13.0 0.3 0.44 10.9 0.0 2.2 3 0 0 3 3 3 0 DsrE/DsrF-like family BsuBI_PstI_RE PF06616.11 ORX53667.1 - 0.039 13.3 0.0 0.061 12.6 0.0 1.3 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain SRF-TF PF00319.18 ORX53668.1 - 1.4e-24 85.3 0.1 2.2e-24 84.6 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) SpoU_methylase PF00588.19 ORX53669.1 - 1.8e-09 37.9 0.0 7.6e-08 32.6 0.0 2.5 2 1 0 2 2 2 1 SpoU rRNA Methylase family GCD14 PF08704.10 ORX53670.1 - 1.1e-91 306.9 0.0 1.3e-91 306.7 0.0 1.1 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_31 PF13847.6 ORX53670.1 - 8.7e-07 28.9 0.0 1.5e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX53670.1 - 5.5e-06 26.3 0.0 8.5e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GCD14_N PF14801.6 ORX53670.1 - 4.9e-05 23.1 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_24 PF13578.6 ORX53670.1 - 0.00036 21.5 0.0 0.00096 20.1 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53670.1 - 0.0079 16.9 0.0 0.015 16.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 ORX53670.1 - 0.0087 15.7 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Ubie_methyltran PF01209.18 ORX53670.1 - 0.041 13.2 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_3 PF01596.17 ORX53670.1 - 0.049 12.8 0.0 0.086 12.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Fibrillarin PF01269.17 ORX53670.1 - 0.051 12.7 0.0 0.083 12.0 0.0 1.4 1 1 0 1 1 1 0 Fibrillarin Methyltransf_23 PF13489.6 ORX53670.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ORX53670.1 - 0.2 11.2 0.0 0.78 9.3 0.0 1.9 1 1 1 2 2 2 0 Methyltransferase small domain Kinase-PPPase PF03618.14 ORX53671.1 - 0.017 14.9 0.1 0.019 14.7 0.1 1.1 1 0 0 1 1 1 0 Kinase/pyrophosphorylase Mis14 PF08641.12 ORX53671.1 - 0.041 14.2 0.4 0.047 14.0 0.4 1.1 1 0 0 1 1 1 0 Kinetochore protein Mis14 like Alba PF01918.21 ORX53673.1 - 0.00038 20.2 0.0 0.00048 19.9 0.0 1.1 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 ORX53673.1 - 0.0091 16.0 0.1 0.14 12.1 0.0 1.9 1 1 1 2 2 2 1 Rpp20 subunit of nuclear RNase MRP and P DUF2152 PF10222.9 ORX53673.1 - 0.049 12.0 0.0 0.05 11.9 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) GCFC PF07842.12 ORX53674.1 - 7.7e-10 38.8 0.4 3.4e-08 33.4 0.4 3.3 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein DUF1664 PF07889.12 ORX53674.1 - 0.0093 16.0 3.2 0.03 14.4 0.7 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) DUF948 PF06103.11 ORX53674.1 - 0.011 15.9 1.0 2 8.7 0.3 3.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DASH_Dam1 PF08653.10 ORX53674.1 - 1.2 9.0 3.9 75 3.2 0.0 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 Tim44 PF04280.15 ORX53675.1 - 2.7e-25 89.2 0.0 4e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Tim44-like domain MBA1 PF07961.11 ORX53675.1 - 5.3e-08 32.2 0.0 6.8e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 MBA1-like protein UTP25 PF06862.12 ORX53676.1 - 1.8e-192 640.3 7.1 2.6e-192 639.8 7.1 1.2 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 SOR_SNZ PF01680.17 ORX53678.1 - 3.9e-113 376.3 10.7 4e-113 376.2 7.8 1.9 2 0 0 2 2 2 1 SOR/SNZ family ThiG PF05690.14 ORX53678.1 - 3.6e-10 39.6 9.3 7.2e-08 32.0 0.9 2.4 1 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ORX53678.1 - 1.8e-05 24.0 1.0 0.16 11.0 0.1 2.7 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) OMPdecase PF00215.24 ORX53678.1 - 0.00022 20.9 0.2 0.61 9.6 0.0 2.5 1 1 1 2 2 2 2 Orotidine 5'-phosphate decarboxylase / HUMPS family NanE PF04131.14 ORX53678.1 - 0.0037 16.5 0.6 0.12 11.5 0.0 2.7 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 ORX53678.1 - 0.008 15.7 0.4 0.18 11.2 0.0 2.6 2 1 0 2 2 2 1 Histidine biosynthesis protein IGPS PF00218.21 ORX53678.1 - 0.0082 15.3 0.2 0.22 10.7 0.0 2.5 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase TetR_C_27 PF17935.1 ORX53678.1 - 0.037 14.1 0.0 0.092 12.8 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain NMO PF03060.15 ORX53678.1 - 0.084 12.2 6.4 0.18 11.1 0.4 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase Peptidase_S66C PF17676.1 ORX53678.1 - 0.16 12.5 0.0 0.39 11.3 0.0 1.7 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain Peptidase_M16_M PF16187.5 ORX53679.1 - 1.2e-91 306.9 1.9 2.2e-91 306.0 1.9 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ORX53679.1 - 8.1e-38 129.7 0.0 8.1e-38 129.7 0.0 2.6 4 0 0 4 4 4 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX53679.1 - 8.6e-31 107.4 1.7 1.5e-20 74.0 0.0 4.3 4 0 0 4 4 4 3 Peptidase M16 inactive domain AAA PF00004.29 ORX53680.1 - 5.1e-44 149.9 0.0 1.7e-43 148.2 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX53680.1 - 6.3e-13 48.3 0.1 1.5e-12 47.1 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ORX53680.1 - 1.6e-08 34.4 1.4 3.9e-08 33.1 1.4 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 ORX53680.1 - 2.1e-07 31.2 0.0 4.6e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ORX53680.1 - 1.8e-06 28.0 0.0 1.1e-05 25.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX53680.1 - 2.2e-06 28.1 0.1 6.9e-05 23.3 0.1 2.8 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX53680.1 - 2.9e-05 24.3 0.6 0.005 17.1 0.1 2.7 2 1 0 2 2 1 1 AAA domain RuvB_N PF05496.12 ORX53680.1 - 8e-05 22.4 0.0 0.00017 21.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ORX53680.1 - 0.0011 18.2 0.0 0.0027 17.0 0.0 1.6 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_33 PF13671.6 ORX53680.1 - 0.0014 18.8 0.0 0.0033 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX53680.1 - 0.0024 17.6 0.0 0.0048 16.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 ORX53680.1 - 0.0048 17.4 0.1 0.022 15.3 0.0 2.1 3 0 0 3 3 1 1 AAA domain DUF2072 PF09845.9 ORX53680.1 - 0.0059 16.9 0.3 0.014 15.7 0.3 1.5 1 0 0 1 1 1 1 Zn-ribbon containing protein AAA_3 PF07726.11 ORX53680.1 - 0.0067 16.3 0.0 0.017 15.0 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ORX53680.1 - 0.0084 15.5 0.1 0.019 14.3 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ORX53680.1 - 0.011 16.0 0.0 0.02 15.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ORX53680.1 - 0.011 15.2 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 ORX53680.1 - 0.015 15.0 0.0 0.1 12.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ORX53680.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ORX53680.1 - 0.022 14.1 0.0 0.058 12.7 0.0 1.7 1 0 0 1 1 1 0 KaiC Sigma54_activat PF00158.26 ORX53680.1 - 0.024 14.3 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_14 PF13173.6 ORX53680.1 - 0.029 14.4 0.0 0.062 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX53680.1 - 0.03 14.7 0.2 0.65 10.3 0.0 2.8 3 0 0 3 3 3 0 AAA domain DUF815 PF05673.13 ORX53680.1 - 0.036 13.2 0.0 0.069 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_7 PF12775.7 ORX53680.1 - 0.036 13.6 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region RILP PF11461.8 ORX53680.1 - 0.037 14.2 1.2 0.092 13.0 1.2 1.6 1 0 0 1 1 1 0 Rab interacting lysosomal protein RNA_helicase PF00910.22 ORX53680.1 - 0.046 14.1 0.0 0.091 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Spc7 PF08317.11 ORX53680.1 - 0.052 12.4 0.2 0.15 10.9 0.2 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein AAA_25 PF13481.6 ORX53680.1 - 0.056 13.0 0.0 0.17 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ORX53680.1 - 0.057 12.5 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 ORX53680.1 - 0.082 12.2 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin V-SNARE PF05008.15 ORX53680.1 - 1 9.8 4.2 0.52 10.7 1.1 2.0 2 0 0 2 2 1 0 Vesicle transport v-SNARE protein N-terminus eIF3_N PF09440.10 ORX53681.1 - 6.9e-46 156.0 6.9 6.9e-46 156.0 6.9 2.7 2 1 1 3 3 3 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 ORX53681.1 - 1.3e-14 54.6 1.4 3.2e-14 53.3 0.4 2.2 2 0 0 2 2 2 1 PCI domain CSN8_PSD8_EIF3K PF10075.9 ORX53681.1 - 0.011 15.7 1.5 0.14 12.1 0.1 2.5 2 0 0 2 2 2 0 CSN8/PSMD8/EIF3K family RIH_assoc PF08454.11 ORX53681.1 - 0.034 14.0 0.7 1.2 9.0 1.7 2.5 1 1 1 2 2 2 0 RyR and IP3R Homology associated B3 PF02362.21 ORX53681.1 - 0.084 12.7 0.1 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 B3 DNA binding domain Nit_Regul_Hom PF10126.9 ORX53681.1 - 0.62 10.1 3.7 0.69 10.0 0.9 2.2 2 0 0 2 2 2 0 Uncharacterized protein, homolog of nitrogen regulatory protein PII Methyltransf_25 PF13649.6 ORX53683.1 - 1e-13 51.8 0.0 1.5e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX53683.1 - 4.4e-12 46.5 0.0 6.7e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX53683.1 - 2.9e-07 30.4 0.0 3.8e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX53683.1 - 4.7e-05 22.9 0.0 6.5e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 ORX53683.1 - 6.4e-05 22.3 0.0 6.9e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 ORX53683.1 - 0.00083 20.1 0.0 0.0022 18.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ORX53683.1 - 0.005 16.1 0.0 0.18 11.0 0.0 2.1 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.17 ORX53683.1 - 0.0055 16.2 0.0 0.041 13.3 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.6 ORX53683.1 - 0.008 16.0 0.0 0.034 13.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ORX53683.1 - 0.016 15.3 0.0 0.025 14.7 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase CheR PF01739.18 ORX53683.1 - 0.016 14.7 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MTS PF05175.14 ORX53683.1 - 0.033 13.8 0.0 0.05 13.2 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase small domain Methyltransf_29 PF03141.16 ORX53683.1 - 0.038 12.6 0.0 0.29 9.6 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MFS_2 PF13347.6 ORX53684.1 - 3e-06 26.1 16.5 3e-06 26.1 16.5 2.6 2 1 0 2 2 2 1 MFS/sugar transport protein DUF3611 PF12263.8 ORX53684.1 - 0.14 12.1 5.0 3.4 7.5 0.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3611) eIF-5a PF01287.20 ORX53685.1 - 4.8e-26 90.6 0.4 6.8e-26 90.2 0.4 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 ORX53685.1 - 0.0099 15.9 0.0 0.017 15.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain SRPRB PF09439.10 ORX53686.1 - 2.4e-33 115.1 0.0 2.8e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ORX53686.1 - 4.8e-13 48.9 0.0 6.4e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX53686.1 - 7.8e-06 25.6 0.1 1e-05 25.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX53686.1 - 5.9e-05 23.1 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ORX53686.1 - 7.3e-05 22.7 0.1 8.7e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein Roc PF08477.13 ORX53686.1 - 0.00018 21.7 0.0 0.00029 21.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX53686.1 - 0.00023 20.6 0.1 0.00026 20.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 ORX53686.1 - 0.0082 15.8 0.0 0.0095 15.5 0.0 1.2 1 0 0 1 1 1 1 Ras family NOG1 PF06858.14 ORX53686.1 - 0.063 13.1 1.0 0.95 9.3 1.0 2.5 1 1 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) FeoB_N PF02421.18 ORX53686.1 - 0.076 12.5 0.3 0.36 10.3 0.3 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B Aminotran_1_2 PF00155.21 ORX53687.1 - 1.3e-18 67.3 0.0 1.5e-18 67.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ORX53687.1 - 0.0042 15.9 0.0 0.0054 15.6 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase tRNA_synt_1c_R2 PF04557.15 ORX53688.1 - 0.14 13.1 0.2 0.3 12.0 0.2 1.6 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 SOG2 PF10428.9 ORX53688.1 - 2.7 7.1 17.4 3.9 6.6 11.3 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein CCDC53 PF10152.9 ORX53688.1 - 7.8 6.9 9.4 0.85 10.0 2.4 2.3 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex p450 PF00067.22 ORX53689.1 - 9.1e-85 285.1 0.0 1.6e-84 284.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Glyco_hydro_48 PF02011.15 ORX53689.1 - 0.15 10.6 0.1 0.55 8.7 0.0 1.7 1 1 1 2 2 2 0 Glycosyl hydrolase family 48 RhoGEF PF00621.20 ORX53691.1 - 4e-26 92.4 0.3 2.5e-25 89.8 0.0 2.3 3 0 0 3 3 3 1 RhoGEF domain BAR PF03114.18 ORX53691.1 - 3e-14 53.3 0.5 3e-14 53.3 0.5 2.1 2 1 0 2 2 2 1 BAR domain DUF1759 PF03564.15 ORX53691.1 - 0.0035 17.3 3.5 0.17 11.9 0.1 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF1759) DUF2408 PF10303.9 ORX53691.1 - 0.0058 17.2 0.3 0.015 15.9 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) Med9 PF07544.13 ORX53691.1 - 0.022 14.9 2.2 0.058 13.5 2.2 1.8 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF4473 PF14747.6 ORX53691.1 - 0.063 13.8 0.0 16 6.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) CHASE3 PF05227.13 ORX53691.1 - 0.15 12.0 5.8 8.9 6.2 0.0 3.1 2 1 1 3 3 3 0 CHASE3 domain Sec5 PF15469.6 ORX53691.1 - 0.64 9.8 4.2 35 4.1 0.0 3.8 1 1 3 4 4 4 0 Exocyst complex component Sec5 TBCC_N PF16752.5 ORX53691.1 - 0.81 10.2 3.3 0.71 10.3 0.1 2.4 3 0 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain MAD PF05557.13 ORX53692.1 - 0.073 11.4 0.1 0.084 11.2 0.1 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein YrzK PF17449.2 ORX53692.1 - 0.17 12.2 0.3 0.37 11.1 0.3 1.6 1 0 0 1 1 1 0 Uncharacterized YrzK-like OrsD PF12013.8 ORX53694.1 - 6.8e-10 39.4 2.1 1.9e-09 37.9 2.1 1.8 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D zf-C2H2_12 PF18658.1 ORX53694.1 - 0.0027 17.2 2.9 0.0078 15.8 2.9 1.7 1 0 0 1 1 1 1 Zinc-finger C2H2-type CK2S PF15011.6 ORX53917.1 - 0.035 14.0 3.9 3.8 7.4 0.0 2.8 3 0 0 3 3 3 0 Casein Kinase 2 substrate HTH_32 PF13565.6 ORX53918.1 - 5.3e-07 30.2 0.0 6.5e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX53918.1 - 3.4e-05 23.8 0.0 8.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 ORX53918.1 - 4.8e-05 23.4 0.1 7.7e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX53918.1 - 0.00091 18.9 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX53918.1 - 0.05 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Peptidase_M24 PF00557.24 ORX53919.1 - 8e-15 55.1 0.0 1.1e-14 54.7 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 HTH_9 PF08221.11 ORX53919.1 - 0.062 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Pro_CA PF00484.19 ORX53920.1 - 3.5e-48 163.8 1.4 5.5e-48 163.2 1.4 1.3 1 0 0 1 1 1 1 Carbonic anhydrase WD40 PF00400.32 ORX53920.1 - 3.3e-06 27.7 6.2 0.0019 19.0 0.1 4.0 5 0 0 5 5 5 2 WD domain, G-beta repeat zf-C2H2 PF00096.26 ORX53921.1 - 7e-22 76.6 24.3 9.9e-07 28.9 0.2 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX53921.1 - 1.7e-21 75.6 15.9 6.2e-07 29.6 0.1 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX53921.1 - 2.3e-12 46.6 23.8 0.0026 18.4 0.4 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX53921.1 - 0.0029 17.3 1.0 0.0029 17.3 1.0 4.0 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-TRAF PF02176.18 ORX53921.1 - 0.016 15.8 14.7 0.058 14.1 3.9 3.0 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_aberr PF17017.5 ORX53921.1 - 0.55 10.4 11.1 0.73 10.0 0.1 3.4 1 1 3 4 4 4 0 Aberrant zinc-finger E_raikovi_mat PF06360.11 ORX53921.1 - 1 9.9 11.6 3.7 8.0 0.4 3.3 3 0 0 3 3 3 0 Euplotes raikovi mating pheromone FOXP-CC PF16159.5 ORX53921.1 - 1.3 9.7 7.5 11 6.7 0.1 3.6 2 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX53921.1 - 1.7 9.1 10.2 3 8.2 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding ING PF12998.7 ORX53922.1 - 0.089 13.4 0.3 0.29 11.8 0.3 1.9 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Aha1_N PF09229.11 ORX53923.1 - 3.7e-36 124.3 0.3 4.3e-36 124.1 0.3 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal PC-Esterase PF13839.6 ORX53924.1 - 5.1e-05 23.2 0.1 0.0011 18.8 0.1 2.2 2 0 0 2 2 2 2 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p ELO PF01151.18 ORX53925.1 - 2.4e-55 187.8 30.6 2.7e-55 187.6 30.6 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family CCSMST1 PF15013.6 ORX53925.1 - 4.4 7.5 9.7 4.7 7.4 0.4 2.6 1 1 1 2 2 2 0 CCSMST1 family RhoGAP PF00620.27 ORX53926.1 - 2.7e-33 114.9 0.0 4.1e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain HMGL-like PF00682.19 ORX53927.1 - 9.7e-81 271.2 0.4 1.4e-80 270.7 0.4 1.2 1 0 0 1 1 1 1 HMGL-like Glyco_hydro_63 PF03200.16 ORX53928.1 - 3.4e-167 557.1 5.5 1.1e-165 552.2 5.5 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 ORX53928.1 - 3.3e-73 246.5 0.0 7.4e-73 245.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain MRP-L47 PF06984.13 ORX53929.1 - 8.4e-27 93.1 1.4 1.3e-26 92.5 1.4 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Ribosomal_L29 PF00831.23 ORX53929.1 - 1e-06 28.6 2.0 2.3e-06 27.4 2.0 1.6 1 1 0 1 1 1 1 Ribosomal L29 protein RNA_pol_Rbc25 PF08292.12 ORX53929.1 - 0.01 16.0 0.3 0.018 15.2 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 G-alpha PF00503.20 ORX53930.1 - 2.1e-117 392.2 5.9 2.4e-117 392.0 5.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX53930.1 - 3.7e-16 59.1 4.8 6.5e-12 45.3 0.7 2.9 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX53930.1 - 0.00019 20.9 5.2 0.0021 17.5 0.3 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX53930.1 - 0.0021 18.3 0.2 2.4 8.4 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ORX53930.1 - 0.013 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ORX53930.1 - 0.016 14.6 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_15 PF13175.6 ORX53930.1 - 0.018 14.8 2.1 0.036 13.8 0.0 2.0 1 1 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX53930.1 - 0.036 14.2 0.2 3.9 7.6 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase BRO1 PF03097.18 ORX53931.1 - 8.5e-127 423.2 1.4 1.2e-126 422.6 0.0 1.9 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ORX53931.1 - 8.4e-53 179.6 13.1 1.7e-52 178.6 13.1 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Lant_dehydr_C PF14028.6 ORX53931.1 - 0.34 10.4 5.3 0.26 10.8 0.9 2.4 2 0 0 2 2 2 0 Lantibiotic biosynthesis dehydratase C-term Syntaxin-6_N PF09177.11 ORX53931.1 - 0.38 11.3 5.1 0.6 10.7 2.7 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal EF-G-binding_N PF07299.11 ORX53931.1 - 0.7 10.4 5.1 1.1 9.8 2.9 2.5 1 1 1 2 2 2 0 Elongation factor G-binding protein, N-terminal Arm PF00514.23 ORX53932.1 - 6.7e-30 102.2 16.8 5.2e-06 26.3 0.1 9.2 10 0 0 10 10 9 7 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ORX53932.1 - 5.5e-14 51.1 13.3 5.3e-06 26.2 0.2 7.7 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ORX53932.1 - 1.1e-12 48.1 6.9 0.002 18.5 0.4 4.9 2 2 4 6 6 6 4 HEAT repeats Adaptin_N PF01602.20 ORX53932.1 - 1.8e-07 30.1 10.9 4e-05 22.4 2.1 2.8 2 2 0 2 2 2 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX53932.1 - 7.8e-07 29.6 1.5 4.7e-05 23.9 0.1 3.2 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ORX53932.1 - 1.5e-06 28.5 16.5 0.0027 18.2 0.8 5.9 4 3 2 6 6 6 2 HEAT-like repeat Cnd1 PF12717.7 ORX53932.1 - 2.8e-06 27.5 10.5 4.3e-05 23.6 2.9 3.1 2 2 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 ORX53932.1 - 0.00067 18.9 7.9 0.52 9.4 0.2 4.6 1 1 3 5 5 5 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 ORX53932.1 - 0.002 17.7 6.5 0.3 10.6 0.2 3.3 2 1 1 3 3 3 1 CLASP N terminal V-ATPase_H_C PF11698.8 ORX53932.1 - 0.0024 18.0 6.0 0.4 10.8 0.1 4.2 3 2 2 5 5 5 1 V-ATPase subunit H DUF3361 PF11841.8 ORX53932.1 - 0.029 14.3 0.2 0.029 14.3 0.2 4.3 2 2 3 5 5 5 0 Domain of unknown function (DUF3361) Radial_spoke_3 PF06098.11 ORX53932.1 - 0.18 11.0 1.7 0.31 10.3 0.1 2.1 3 0 0 3 3 3 0 Radial spoke protein 3 Uso1_p115_head PF04869.14 ORX53932.1 - 1.2 8.2 4.7 0.86 8.7 0.7 2.5 1 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, head region DCB PF16213.5 ORX53932.1 - 1.9 8.1 8.8 0.25 11.0 0.4 3.1 3 1 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 ATP-synt_C PF00137.21 ORX53933.1 - 1.5e-31 108.5 31.0 7.9e-19 67.8 12.7 2.3 2 0 0 2 2 2 2 ATP synthase subunit C MBOAT PF03062.19 ORX53934.1 - 2e-38 132.6 20.9 2e-38 132.6 20.9 2.5 2 1 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family Septin PF00735.18 ORX53935.1 - 3.6e-123 410.3 1.5 3.6e-123 410.3 1.5 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ORX53935.1 - 3.5e-09 36.7 0.9 7.1e-09 35.8 0.0 1.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX53935.1 - 1.4e-05 25.0 6.6 3.8e-05 23.7 0.1 2.9 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ORX53935.1 - 0.0001 21.9 4.3 0.0033 17.0 0.0 3.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX53935.1 - 0.00059 20.1 0.3 0.0054 17.0 0.1 2.7 1 1 0 2 2 2 1 AAA domain AIG1 PF04548.16 ORX53935.1 - 0.0014 18.0 0.0 0.0014 18.0 0.0 2.2 2 0 0 2 2 2 1 AIG1 family Roc PF08477.13 ORX53935.1 - 0.0019 18.4 0.3 0.0056 16.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX53935.1 - 0.0023 17.6 1.3 0.0052 16.4 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.6 ORX53935.1 - 0.003 18.0 0.0 0.0085 16.5 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 ORX53935.1 - 0.0043 16.8 0.3 0.018 14.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX53935.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 ORX53935.1 - 0.02 15.0 0.2 0.02 15.0 0.2 3.2 2 2 1 3 3 2 0 Dynamin family ABC_tran PF00005.27 ORX53935.1 - 0.05 14.1 9.6 4.6 7.8 9.6 2.8 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ORX53935.1 - 0.1 13.0 0.4 0.4 11.1 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Exonuc_VII_L PF02601.15 ORX53935.1 - 0.19 11.3 7.4 0.31 10.6 7.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.6 ORX53935.1 - 0.33 11.4 16.4 1e+02 3.3 16.4 2.2 1 1 0 1 1 1 0 AAA domain Atg14 PF10186.9 ORX53935.1 - 1.3 8.0 9.4 2.2 7.3 9.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Caskin-tail PF16632.5 ORX53935.1 - 1.6 9.2 0.0 1.6 9.2 0.0 2.9 2 2 0 2 2 2 0 C-terminal region of Caskin DUF1770 PF08589.10 ORX53935.1 - 2.1 9.3 5.1 0.74 10.8 0.8 2.4 3 0 0 3 3 2 0 Fungal protein of unknown function (DUF1770) ATP_bind_1 PF03029.17 ORX53935.1 - 2.3 8.0 8.0 13 5.5 0.2 3.7 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein UPF0242 PF06785.11 ORX53935.1 - 2.4 8.2 17.4 5.5 7.0 17.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Strep_SA_rep PF06696.11 ORX53935.1 - 2.5 8.2 8.8 0.5 10.4 1.1 2.7 1 1 1 2 2 2 0 Streptococcal surface antigen repeat DUF87 PF01935.17 ORX53935.1 - 3.4 7.7 0.0 3.4 7.7 0.0 2.7 2 1 0 2 2 2 0 Helicase HerA, central domain DUF1542 PF07564.11 ORX53935.1 - 9.3 6.4 8.7 0.41 10.8 0.5 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) OGG_N PF07934.12 ORX53936.1 - 1.1e-26 93.2 0.0 2e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 ORX53936.1 - 3e-16 59.8 0.0 4.6e-16 59.2 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ORX53936.1 - 0.00015 21.5 0.0 0.00037 20.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif Herpes_UL24 PF01646.16 ORX53936.1 - 0.039 13.9 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Herpes virus proteins UL24 and UL76 Chs7 PF12271.8 ORX53938.1 - 2.2e-113 378.4 21.6 2.5e-113 378.2 21.6 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone DSPc PF00782.20 ORX53939.1 - 6.1e-27 94.1 0.0 7.1e-27 93.8 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX53939.1 - 0.00027 20.6 0.0 0.0003 20.4 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase zf-CCHC PF00098.23 ORX53940.1 - 8.6e-07 28.8 2.5 1.4e-06 28.0 2.5 1.4 1 0 0 1 1 1 1 Zinc knuckle CTD_bind PF04818.13 ORX53940.1 - 1.8e-06 28.7 0.1 6.8e-06 26.8 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. DnaB_2 PF07261.11 ORX53940.1 - 0.0049 16.6 0.1 0.6 9.9 0.0 2.4 2 0 0 2 2 2 2 Replication initiation and membrane attachment Pkinase PF00069.25 ORX53941.1 - 4.5e-68 229.5 0.0 5.3e-68 229.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53941.1 - 5.5e-28 98.0 0.0 6.9e-28 97.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX53941.1 - 3e-06 26.8 0.1 0.00094 18.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX53941.1 - 0.00012 21.8 0.2 0.00019 21.1 0.2 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ORX53941.1 - 0.0086 15.5 0.3 0.014 14.8 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX53941.1 - 0.043 12.8 0.0 0.077 11.9 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX53941.1 - 0.13 12.2 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Nucleotid_trans PF03407.16 ORX53942.1 - 2.7e-18 66.7 0.2 4.2e-18 66.1 0.2 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase SH3_12 PF18129.1 ORX53943.1 - 1.3e-23 82.9 0.3 1.9e-23 82.3 0.3 1.3 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 ORX53943.1 - 0.019 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Exoribonuclease 1 Domain-3 Aldedh PF00171.22 ORX53944.1 - 2.1e-130 435.4 0.0 2.5e-130 435.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ORX53944.1 - 0.014 14.5 0.0 0.016 14.3 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) G-alpha PF00503.20 ORX53946.1 - 2e-79 267.3 2.3 2.3e-79 267.1 2.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX53946.1 - 4.4e-06 26.2 0.1 0.08 12.4 0.0 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX53946.1 - 0.0019 17.6 1.9 0.078 12.3 0.1 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX53946.1 - 0.0055 16.8 0.0 4.2 7.5 0.0 2.4 2 0 0 2 2 2 2 50S ribosome-binding GTPase RhoGAP PF00620.27 ORX53947.1 - 5.3e-37 127.0 0.0 1e-36 126.1 0.0 1.4 2 0 0 2 2 2 1 RhoGAP domain TatD_DNase PF01026.21 ORX53948.1 - 1e-50 172.5 0.2 1.2e-50 172.3 0.2 1.0 1 0 0 1 1 1 1 TatD related DNase BCL9 PF11502.8 ORX53948.1 - 0.011 15.6 1.0 0.52 10.2 0.1 2.4 2 0 0 2 2 2 0 B-cell lymphoma 9 protein EAP30 PF04157.16 ORX53948.1 - 0.051 12.9 0.0 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 EAP30/Vps36 family Nuc_deoxyrib_tr PF05014.15 ORX53948.1 - 0.065 13.3 0.0 1.3 9.0 0.0 2.2 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase Pkinase PF00069.25 ORX53949.1 - 1.3e-61 208.3 0.1 1.5e-61 208.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX53949.1 - 4.9e-40 137.5 0.1 6.5e-40 137.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX53949.1 - 1.9e-08 34.0 0.0 2.9e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX53949.1 - 3.1e-05 23.0 0.0 3.5e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX53949.1 - 0.0039 16.2 0.1 0.0082 15.1 0.1 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ORX53949.1 - 0.06 12.4 0.0 0.091 11.8 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 ORX53949.1 - 0.19 11.6 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3552 PF12072.8 ORX53950.1 - 0.0082 15.6 12.8 0.01 15.3 12.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) Spc7 PF08317.11 ORX53950.1 - 0.012 14.5 14.0 0.014 14.2 14.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 ORX53950.1 - 0.031 13.9 8.5 0.036 13.7 8.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2046 PF09755.9 ORX53950.1 - 0.031 13.5 12.0 0.037 13.3 12.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) MRP-S26 PF14943.6 ORX53950.1 - 0.035 14.0 12.1 0.059 13.3 12.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 Atg14 PF10186.9 ORX53950.1 - 0.059 12.5 15.0 0.072 12.2 15.0 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Allexi_40kDa PF05549.11 ORX53950.1 - 0.16 11.5 9.9 0.2 11.1 9.9 1.2 1 0 0 1 1 1 0 Allexivirus 40kDa protein FlaC_arch PF05377.11 ORX53950.1 - 0.19 12.1 9.3 1.2 9.6 9.3 2.3 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) HOOK PF05622.12 ORX53950.1 - 0.24 9.5 15.0 0.27 9.3 15.0 1.1 1 0 0 1 1 1 0 HOOK protein V_ATPase_I PF01496.19 ORX53950.1 - 0.38 8.6 9.2 0.39 8.6 9.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PNMA PF14893.6 ORX53950.1 - 0.44 9.9 7.6 0.52 9.7 7.6 1.1 1 0 0 1 1 1 0 PNMA TMPIT PF07851.13 ORX53950.1 - 0.51 9.5 11.4 0.62 9.3 11.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4407 PF14362.6 ORX53950.1 - 0.57 9.5 6.0 0.66 9.3 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3573 PF12097.8 ORX53950.1 - 0.83 8.4 4.4 0.89 8.3 4.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) FapA PF03961.13 ORX53950.1 - 0.95 8.0 7.5 1 7.9 7.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 ORX53950.1 - 1.1 7.1 7.0 1.2 7.0 7.0 1.1 1 0 0 1 1 1 0 Prominin IFT20 PF14931.6 ORX53950.1 - 1.7 8.8 15.8 2.5 8.3 14.7 1.8 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 Tweety PF04906.13 ORX53950.1 - 1.9 7.1 6.5 2.9 6.5 6.5 1.3 1 0 0 1 1 1 0 Tweety Med9 PF07544.13 ORX53950.1 - 2.2 8.4 20.1 0.54 10.4 5.1 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 GBP_C PF02841.14 ORX53950.1 - 2.2 7.6 16.6 2.8 7.3 16.6 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain FAM76 PF16046.5 ORX53950.1 - 2.2 7.5 15.7 2.2 7.6 14.9 1.3 1 1 0 1 1 1 0 FAM76 protein TAF4 PF05236.14 ORX53950.1 - 2.3 7.9 15.0 4.1 7.1 15.0 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Hid1 PF12722.7 ORX53950.1 - 3 5.9 10.3 3.4 5.7 10.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Spc110_C PF18520.1 ORX53950.1 - 4.6 6.9 5.9 0.78 9.4 1.1 2.1 3 0 0 3 3 3 0 Spindle pole body component 110 C-terminal domain Cdh1_DBD_1 PF18196.1 ORX53950.1 - 4.7 7.5 9.8 5.6 7.3 8.1 1.9 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Csm1_N PF18504.1 ORX53950.1 - 7.4 7.0 16.0 0.59 10.5 9.0 2.6 2 1 2 4 4 3 0 Csm1 N-terminal domain Metallophos PF00149.28 ORX53951.1 - 1.6e-34 120.2 0.1 2.2e-34 119.8 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX53951.1 - 0.038 14.4 0.2 0.08 13.4 0.2 1.5 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Glyco_hydro_65N PF03636.15 ORX53951.1 - 0.058 13.0 0.0 0.087 12.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Metallophos_2 PF12850.7 ORX53951.1 - 0.18 12.0 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain SurE PF01975.17 ORX53952.1 - 2.3e-44 151.5 0.0 2.7e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Survival protein SurE Ras PF00071.22 ORX53953.1 - 4.3e-60 202.0 0.7 5.7e-60 201.6 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX53953.1 - 7.1e-37 126.3 0.1 1.4e-36 125.3 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX53953.1 - 9.6e-16 57.7 0.4 1.2e-15 57.4 0.4 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX53953.1 - 2.3e-07 30.4 0.2 3.3e-07 29.9 0.2 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ORX53953.1 - 1.4e-05 25.0 0.1 0.011 15.6 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX53953.1 - 3e-05 24.0 0.1 5.3e-05 23.3 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX53953.1 - 4.2e-05 23.2 0.3 0.00028 20.5 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX53953.1 - 4.5e-05 22.9 0.4 5.7e-05 22.6 0.4 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ORX53953.1 - 0.0021 17.6 0.0 0.14 11.7 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ORX53953.1 - 0.0058 16.5 0.4 0.018 14.8 0.1 1.7 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TniB PF05621.11 ORX53953.1 - 0.01 15.3 0.1 0.67 9.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein TIR_2 PF13676.6 ORX53953.1 - 0.031 14.9 0.1 0.059 14.0 0.1 1.5 1 1 0 1 1 1 0 TIR domain FlgH PF02107.16 ORX53953.1 - 0.073 12.7 0.8 0.1 12.2 0.8 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein Ras PF00071.22 ORX53954.1 - 4.5e-59 198.7 0.1 6e-59 198.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX53954.1 - 3e-37 127.5 0.1 4.5e-37 126.9 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX53954.1 - 3.9e-15 55.7 0.1 5e-15 55.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX53954.1 - 4.5e-07 29.5 0.0 6.2e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX53954.1 - 8.2e-06 25.3 0.1 1.1e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX53954.1 - 1.8e-05 24.8 0.0 4e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX53954.1 - 0.00011 21.9 0.1 0.0008 19.0 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX53954.1 - 0.00015 21.7 0.2 0.26 11.2 0.0 2.4 3 0 0 3 3 3 2 RsgA GTPase FeoB_N PF02421.18 ORX53954.1 - 0.0067 16.0 0.1 2.8 7.5 0.0 2.3 2 0 0 2 2 2 2 Ferrous iron transport protein B AAA_24 PF13479.6 ORX53954.1 - 0.011 15.4 0.7 0.029 14.1 0.7 1.9 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ORX53954.1 - 0.052 13.6 0.1 3.4 7.7 0.0 2.8 3 1 0 3 3 3 0 Dynamin family AAA_7 PF12775.7 ORX53954.1 - 0.065 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 ORX53954.1 - 0.091 13.0 0.1 1.8 8.8 0.0 2.1 1 1 0 2 2 2 0 AAA domain CPT PF07931.12 ORX53954.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.4 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 ORX53954.1 - 0.2 11.4 1.5 0.21 11.3 0.4 2.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation FKBP_C PF00254.28 ORX53955.1 - 1.5e-22 79.7 0.0 3.4e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 ORX53955.1 - 3.9e-18 66.0 0.0 6.2e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Nucleoplasmin-like domain zf-C3HC4_3 PF13920.6 ORX53956.1 - 4.2e-07 29.7 8.1 7.4e-07 28.9 8.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX53956.1 - 7.8e-06 25.6 11.4 1.6e-05 24.7 11.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX53956.1 - 8.4e-06 25.6 12.1 1.8e-05 24.5 12.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX53956.1 - 1.5e-05 24.9 12.0 2.9e-05 23.9 12.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain BRE1 PF08647.11 ORX53956.1 - 2.9e-05 24.1 4.5 2.9e-05 24.1 4.5 7.9 3 3 3 7 7 5 1 BRE1 E3 ubiquitin ligase Prok-RING_4 PF14447.6 ORX53956.1 - 0.00038 20.3 6.8 0.00074 19.3 6.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ORX53956.1 - 0.00055 20.2 10.9 0.0011 19.2 10.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX53956.1 - 0.0011 19.0 8.2 0.0023 17.9 8.2 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX53956.1 - 0.0097 16.2 7.6 0.029 14.6 7.6 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain HrpB7 PF09486.10 ORX53956.1 - 0.021 15.2 9.0 0.021 15.2 9.0 5.5 4 2 1 5 5 4 0 Bacterial type III secretion protein (HrpB7) zf-RING_6 PF14835.6 ORX53956.1 - 0.031 14.1 4.7 0.068 13.0 4.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ORX53956.1 - 0.43 10.8 6.9 0.95 9.7 6.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ORX53956.1 - 0.48 10.3 8.3 1.4 8.7 8.3 1.9 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.11 ORX53956.1 - 0.67 10.1 6.7 1.6 8.8 6.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-C2H2_6 PF13912.6 ORX53956.1 - 0.85 9.7 4.3 15 5.8 0.0 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger DZR PF12773.7 ORX53956.1 - 3.3 7.8 9.2 9.6 6.3 9.2 1.8 1 0 0 1 1 1 0 Double zinc ribbon Spc7 PF08317.11 ORX53956.1 - 6.8 5.5 72.9 0.87 8.4 5.3 4.6 3 1 1 4 4 4 0 Spc7 kinetochore protein Draxin PF15550.6 ORX53957.1 - 0.0043 17.0 0.1 0.0055 16.6 0.1 1.1 1 0 0 1 1 1 1 Draxin MSL1_dimer PF16801.5 ORX53957.1 - 6 6.7 8.4 10 6.0 8.4 1.3 1 0 0 1 1 1 0 Dimerisation domain of Male-specific-Lethal 1 Ribosomal_S2 PF00318.20 ORX53958.1 - 4.7e-26 91.3 0.5 6.7e-13 48.4 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 ORX53958.1 - 1.4e-05 26.4 5.9 2.5e-05 25.6 5.9 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus MPC PF03650.13 ORX53960.1 - 1.7e-44 150.5 0.1 2e-44 150.2 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Tom6 PF17112.5 ORX53960.1 - 0.32 10.5 1.1 13 5.3 0.2 2.6 2 1 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal UQ_con PF00179.26 ORX53961.1 - 1.6e-37 128.2 0.0 2.8e-37 127.5 0.0 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Galactosyl_T PF01762.21 ORX53962.1 - 1.3e-26 93.6 0.0 1.8e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Galactosyltransferase EOS1 PF12326.8 ORX53962.1 - 1.3e-09 38.2 22.1 1.3e-08 35.0 14.3 2.3 1 1 1 2 2 2 2 N-glycosylation protein Glyco_transf_21 PF13506.6 ORX53962.1 - 0.11 12.0 0.1 0.2 11.1 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 DUF4173 PF13777.6 ORX53962.1 - 3.3 7.1 12.3 1.9 7.9 1.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4173) Methyltransf_11 PF08241.12 ORX53963.1 - 2.1e-22 79.5 0.0 3.8e-22 78.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53963.1 - 7.5e-21 74.6 0.1 1.1e-20 74.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX53963.1 - 3e-20 72.6 0.0 3.6e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX53963.1 - 7.6e-16 58.4 0.0 1e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX53963.1 - 1.1e-13 51.8 0.1 1.6e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ORX53963.1 - 5e-12 45.4 0.0 6.6e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 ORX53963.1 - 1.3e-11 44.3 0.0 1.8e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 ORX53963.1 - 1.5e-09 37.7 0.0 2.4e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX53963.1 - 4e-08 33.0 0.0 6.1e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 ORX53963.1 - 3.3e-07 29.9 0.1 5.1e-07 29.3 0.0 1.3 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 ORX53963.1 - 4.6e-06 26.2 0.0 6.7e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_16 PF10294.9 ORX53963.1 - 1.2e-05 25.1 0.0 1.7e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase FtsJ PF01728.19 ORX53963.1 - 4.2e-05 23.7 0.0 6.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 ORX53963.1 - 0.00014 21.7 0.0 0.00021 21.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ORX53963.1 - 0.00055 19.6 0.0 0.0008 19.1 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_29 PF03141.16 ORX53963.1 - 0.00063 18.4 0.0 0.00094 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pox_MCEL PF03291.16 ORX53963.1 - 0.0012 18.0 0.1 0.0024 17.0 0.1 1.4 1 1 0 1 1 1 1 mRNA capping enzyme UPF0020 PF01170.18 ORX53963.1 - 0.0019 17.9 0.0 0.003 17.3 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 ORX53963.1 - 0.0031 17.0 0.0 0.007 15.9 0.0 1.6 1 1 0 1 1 1 1 Putative methyltransferase NNMT_PNMT_TEMT PF01234.17 ORX53963.1 - 0.0046 16.2 0.0 0.03 13.5 0.0 1.9 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Methyltransf_32 PF13679.6 ORX53963.1 - 0.0069 16.4 0.0 0.0096 15.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 ORX53963.1 - 0.017 15.1 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_18 PF12847.7 ORX53963.1 - 0.023 14.6 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 ORX53963.1 - 0.024 14.2 0.0 0.039 13.5 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW NodS PF05401.11 ORX53963.1 - 0.13 11.9 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) PapG_C PF03628.13 ORX53963.1 - 0.16 11.8 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 PapG chaperone-binding domain Methyltransf_11 PF08241.12 ORX53964.1 - 2.5e-21 76.1 0.1 4.2e-21 75.4 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX53964.1 - 1.5e-20 73.5 0.0 1.9e-20 73.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX53964.1 - 1.5e-18 67.2 0.1 2.4e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX53964.1 - 6.1e-15 55.8 0.0 8.8e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX53964.1 - 5.1e-14 52.4 0.0 7e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ORX53964.1 - 1.1e-12 47.5 0.0 1.6e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 ORX53964.1 - 5e-10 39.1 0.0 5.8e-10 38.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 ORX53964.1 - 8.3e-09 35.1 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ORX53964.1 - 8.7e-08 31.9 0.0 1.3e-07 31.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ORX53964.1 - 2e-05 24.3 0.0 2.8e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PCMT PF01135.19 ORX53964.1 - 6.9e-05 22.7 0.0 0.00011 22.0 0.0 1.4 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ORX53964.1 - 0.00026 20.6 0.0 0.0004 20.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX53964.1 - 0.0029 17.1 0.0 0.024 14.1 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase TehB PF03848.14 ORX53964.1 - 0.0038 16.6 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.17 ORX53964.1 - 0.0062 15.8 0.0 0.14 11.3 0.0 2.1 2 0 0 2 2 2 1 NNMT/PNMT/TEMT family ADH_zinc_N_2 PF13602.6 ORX53964.1 - 0.05 14.7 0.0 0.079 14.0 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_16 PF10294.9 ORX53964.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 Lysine methyltransferase Methyltransf_18 PF12847.7 ORX53964.1 - 0.2 11.6 0.0 0.3 11.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Pox_MCEL PF03291.16 ORX53964.1 - 0.25 10.4 0.1 0.49 9.4 0.1 1.5 1 1 0 1 1 1 0 mRNA capping enzyme KELK PF15796.5 ORX53965.1 - 5.1 7.6 20.1 23 5.5 1.6 3.9 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase zf-C2H2_6 PF13912.6 ORX53966.1 - 2.7e-05 24.0 3.1 0.095 12.7 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX53966.1 - 0.0005 20.7 9.0 0.034 15.0 0.8 3.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX53966.1 - 0.026 15.0 9.2 0.84 10.2 2.4 3.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ORX53966.1 - 0.033 14.5 1.2 0.084 13.2 1.2 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_8 PF15909.5 ORX53966.1 - 1.8 8.9 5.7 58 4.1 3.5 3.4 2 1 0 2 2 2 0 C2H2-type zinc ribbon Methyltransf_9 PF08003.11 ORX53967.1 - 6.7e-10 38.4 0.0 8.2e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_25 PF13649.6 ORX53967.1 - 9.2e-09 35.9 0.0 1.2e-08 35.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX53967.1 - 3.6e-08 33.9 0.0 5.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX53967.1 - 7.1e-08 32.4 0.0 8.6e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX53967.1 - 2e-06 27.3 0.0 2.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ORX53967.1 - 4.8e-05 23.2 0.0 5.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX53967.1 - 7e-05 22.7 0.0 0.00014 21.7 0.0 1.5 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ORX53967.1 - 0.00011 21.9 0.0 0.00016 21.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 ORX53967.1 - 0.00051 19.5 0.0 0.00063 19.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 ORX53967.1 - 0.00089 18.6 0.0 0.00092 18.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX53967.1 - 0.0011 19.6 0.0 0.0016 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX53967.1 - 0.036 13.6 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_4 PF02390.17 ORX53967.1 - 0.04 13.4 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Peptidase_C33 PF05412.12 ORX53967.1 - 0.041 13.9 0.1 0.06 13.4 0.1 1.2 1 0 0 1 1 1 0 Equine arterivirus Nsp2-type cysteine proteinase Methyltransf_18 PF12847.7 ORX53967.1 - 0.054 13.4 0.0 0.069 13.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 ORX53967.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Gpi16 PF04113.14 ORX53967.1 - 0.12 10.8 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Gpi16 subunit, GPI transamidase component Kinesin PF00225.23 ORX53969.1 - 9.1e-113 376.6 0.0 1.9e-112 375.5 0.0 1.6 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ORX53969.1 - 4.5e-45 154.0 5.4 4.5e-45 154.0 5.4 3.1 2 1 0 2 2 2 1 Kinesin-associated DUF3694 PF12473.8 ORX53969.1 - 1.1e-39 136.6 0.5 3e-39 135.1 0.5 1.8 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 ORX53969.1 - 8e-28 97.3 0.0 2.6e-27 95.6 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 ORX53969.1 - 1.7e-13 51.0 0.3 5.3e-13 49.4 0.3 1.9 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ORX53969.1 - 0.0052 17.1 0.8 0.034 14.5 0.8 2.4 1 1 0 1 1 1 1 Pleckstrin homology domain KIF1B PF12423.8 ORX53969.1 - 0.012 16.0 0.1 0.043 14.3 0.1 2.0 1 0 0 1 1 1 0 Kinesin protein 1B PTSIIB_sorb PF03830.15 ORX53969.1 - 0.1 12.8 0.6 0.29 11.3 0.0 2.0 2 0 0 2 2 2 0 PTS system sorbose subfamily IIB component FAD_binding_2 PF00890.24 ORX53970.1 - 5.5e-85 286.0 0.8 7.1e-85 285.6 0.8 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 ORX53970.1 - 6.9e-23 80.6 0.1 1.5e-21 76.3 0.0 3.0 4 0 0 4 4 4 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 ORX53970.1 - 8.9e-14 51.8 0.1 1.8e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ORX53970.1 - 3.8e-08 33.1 0.1 6e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX53970.1 - 5.7e-08 32.9 0.4 1.9e-07 31.2 0.1 2.1 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX53970.1 - 6.9e-06 25.5 0.0 2.5e-05 23.7 0.0 1.9 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX53970.1 - 7.7e-06 24.9 2.7 0.00057 18.7 0.1 2.5 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 ORX53970.1 - 0.0013 18.0 0.4 0.026 13.8 0.1 2.4 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ORX53970.1 - 0.0051 16.1 0.1 0.0093 15.2 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ORX53970.1 - 0.0056 16.0 0.0 0.076 12.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Ribosomal_60s PF00428.19 ORX53970.1 - 0.0057 17.2 1.4 0.015 15.9 1.4 1.7 1 0 0 1 1 1 1 60s Acidic ribosomal protein GIDA PF01134.22 ORX53970.1 - 0.0067 15.6 2.5 0.0085 15.2 0.2 2.2 3 0 0 3 3 3 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 ORX53970.1 - 0.031 13.6 0.1 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ORX53970.1 - 0.081 13.5 0.2 1.7 9.2 0.0 2.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ORX53970.1 - 0.15 11.3 0.3 0.66 9.2 0.0 2.1 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 ORX53970.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Metallophos PF00149.28 ORX53971.1 - 1.9e-38 133.1 0.1 4.3e-38 131.9 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 ORX53971.1 - 0.066 12.5 0.0 0.098 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Acyltransferase PF01553.21 ORX53972.1 - 6e-08 32.4 0.0 2.2e-07 30.6 0.0 2.0 1 1 0 1 1 1 1 Acyltransferase F-box_4 PF15966.5 ORX53973.1 - 2.2e-05 24.3 0.8 2.2e-05 24.3 0.8 2.5 2 1 1 3 3 3 1 F-box F-box PF00646.33 ORX53973.1 - 0.00026 20.8 2.0 0.0025 17.7 0.1 3.0 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ORX53973.1 - 0.0012 18.7 2.1 0.0015 18.4 0.8 2.0 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ORX53973.1 - 0.014 15.8 10.9 0.64 10.5 0.1 4.6 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX53973.1 - 0.38 10.9 8.9 5 7.4 0.1 5.7 7 0 0 7 7 7 0 Leucine Rich repeat LRR_1 PF00560.33 ORX53973.1 - 1.1 10.0 15.4 95 4.2 0.0 6.5 6 0 0 6 6 6 0 Leucine Rich Repeat HMA PF00403.26 ORX53974.1 - 4.1e-53 177.7 5.6 1e-11 45.1 0.0 6.0 6 0 0 6 6 6 5 Heavy-metal-associated domain E1-E2_ATPase PF00122.20 ORX53974.1 - 1.8e-47 161.2 2.2 1.8e-47 161.2 2.2 2.0 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX53974.1 - 6e-33 114.9 0.3 2.4e-32 113.0 0.2 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX53974.1 - 3.4e-05 23.7 0.2 0.00015 21.6 0.3 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX53974.1 - 0.002 18.6 0.0 0.0047 17.4 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 ORX53975.1 - 2.3e-16 60.6 0.0 9.9e-16 58.5 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX53975.1 - 1.2e-12 48.2 1.1 9.2e-06 25.7 0.1 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_25 PF13481.6 ORX53975.1 - 0.004 16.7 0.2 0.011 15.3 0.0 1.7 1 1 1 2 2 2 1 AAA domain AAA_23 PF13476.6 ORX53975.1 - 0.012 16.1 0.2 0.059 13.9 0.1 1.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ORX53975.1 - 0.022 14.2 0.4 4.8 6.5 0.1 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 ORX53975.1 - 0.032 14.8 0.0 0.073 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ORX53975.1 - 0.033 11.7 0.2 0.048 11.2 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) AAA_28 PF13521.6 ORX53975.1 - 0.037 14.3 1.0 0.059 13.6 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ORX53975.1 - 0.04 13.7 0.0 0.078 12.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX53975.1 - 0.062 13.2 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Arf PF00025.21 ORX53975.1 - 0.076 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family PduV-EutP PF10662.9 ORX53975.1 - 0.077 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ORX53975.1 - 0.087 12.7 0.7 0.27 11.1 0.1 2.1 3 0 0 3 3 3 0 NACHT domain AAA_15 PF13175.6 ORX53975.1 - 0.099 12.3 0.1 0.21 11.3 0.1 1.5 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ORX53975.1 - 0.13 12.3 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ORX53975.1 - 0.17 11.6 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX53975.1 - 0.18 12.0 0.2 0.39 10.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ORX53975.1 - 0.19 11.3 0.0 0.44 10.1 0.2 1.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Promethin PF16015.5 ORX53976.1 - 0.019 14.9 1.2 0.058 13.3 0.2 2.4 2 1 0 2 2 2 0 Promethin TMEM135_C_rich PF15982.5 ORX53977.1 - 0.0021 18.7 0.1 0.0055 17.3 0.0 1.7 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 zf-C2H2 PF00096.26 ORX53978.1 - 0.00024 21.4 4.0 0.00035 20.9 1.4 2.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type TFIIA PF03153.13 ORX53978.1 - 0.0064 16.5 22.9 0.0097 15.9 22.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-C2H2_4 PF13894.6 ORX53978.1 - 0.01 16.6 2.0 0.039 14.8 1.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger Nop14 PF04147.12 ORX53978.1 - 0.12 10.6 14.3 0.19 9.9 14.3 1.3 1 0 0 1 1 1 0 Nop14-like family zf-C2H2_11 PF16622.5 ORX53978.1 - 0.18 11.6 1.7 0.32 10.8 0.4 2.1 2 0 0 2 2 2 0 zinc-finger C2H2-type CytochromB561_N PF09786.9 ORX53978.1 - 0.41 9.6 8.6 0.52 9.2 8.6 1.2 1 0 0 1 1 1 0 Cytochrome B561, N terminal SDA1 PF05285.12 ORX53978.1 - 8.1 5.8 14.4 12 5.2 14.4 1.3 1 0 0 1 1 1 0 SDA1 G3P_acyltransf PF02660.15 ORX53979.1 - 0.078 13.0 3.3 0.12 12.5 3.3 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase MgtE PF01769.16 ORX53979.1 - 0.42 11.0 4.2 0.65 10.4 4.2 1.2 1 0 0 1 1 1 0 Divalent cation transporter Phage_holin_3_6 PF07332.11 ORX53979.1 - 0.65 10.1 3.8 1.1 9.4 3.8 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4131 PF13567.6 ORX53979.1 - 2.1 8.0 9.4 2.7 7.6 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) SURF4 PF02077.15 ORX53980.1 - 3.7e-86 289.0 7.2 4e-86 288.9 7.2 1.0 1 0 0 1 1 1 1 SURF4 family Gram_pos_anchor PF00746.21 ORX53980.1 - 0.74 9.8 4.8 10 6.1 0.0 3.9 4 0 0 4 4 4 0 LPXTG cell wall anchor motif DoxX PF07681.12 ORX53980.1 - 0.79 10.4 12.8 0.65 10.6 0.3 3.0 2 2 1 3 3 3 0 DoxX Aldose_epim PF01263.20 ORX53981.1 - 3.2e-48 164.6 1.5 3.6e-48 164.4 1.5 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase DUF5462 PF17547.2 ORX53981.1 - 0.09 12.1 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5462) Spore-coat_CotZ PF10612.9 ORX53981.1 - 0.1 12.8 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Spore coat protein Z Ribosomal_S11 PF00411.19 ORX53982.1 - 1.6e-30 105.7 1.3 2.1e-30 105.3 1.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 eIF3g PF12353.8 ORX53983.1 - 6.2e-44 149.4 5.2 6.2e-44 149.4 5.2 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 ORX53983.1 - 1.6e-19 69.5 0.0 3.3e-19 68.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX53983.1 - 0.0046 16.8 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 Occluded RNA-recognition motif NSP11 PF06471.12 ORX53983.1 - 0.005 15.4 0.0 0.0061 15.1 0.0 1.1 1 0 0 1 1 1 1 NSP11 RRM_5 PF13893.6 ORX53983.1 - 0.084 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDV3 PF15359.6 ORX53983.1 - 0.095 13.2 2.8 0.22 12.0 2.9 1.7 1 1 0 1 1 1 0 Carnitine deficiency-associated protein 3 RRM_3 PF08777.11 ORX53983.1 - 0.15 12.1 2.0 1.6 8.9 0.0 2.7 3 0 0 3 3 3 0 RNA binding motif RRM_8 PF11835.8 ORX53983.1 - 0.18 12.0 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 RRM-like domain Tubulin PF00091.25 ORX53984.1 - 2.4e-67 227.0 0.0 3.4e-67 226.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX53984.1 - 1.8e-45 154.2 0.3 5.6e-45 152.6 0.1 1.9 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX53984.1 - 2.1e-05 24.8 0.0 6.1e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ORX53984.1 - 0.00061 19.5 0.0 0.0014 18.3 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain THF_DHG_CYH PF00763.23 ORX53985.1 - 1e-25 90.3 0.1 2.4e-25 89.0 0.0 1.7 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 ORX53985.1 - 4.6e-14 52.0 0.2 5.9e-12 45.2 0.2 2.7 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain UDPG_MGDP_dh_N PF03721.14 ORX53985.1 - 0.012 15.1 0.4 0.48 10.0 0.4 2.6 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 ORX53985.1 - 0.061 12.6 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 ORX53985.1 - 0.16 11.3 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 4HBT PF03061.22 ORX53986.1 - 3.7e-28 97.7 2.3 2.3e-13 50.3 0.0 2.6 3 0 0 3 3 3 2 Thioesterase superfamily Acetyltransf_1 PF00583.25 ORX53987.1 - 9e-14 51.7 0.1 1.2e-13 51.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX53987.1 - 1.5e-09 38.2 0.1 2.2e-09 37.6 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX53987.1 - 2.1e-08 34.1 0.3 2.8e-08 33.7 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain UPF0014 PF03649.13 ORX53988.1 - 7.3e-53 179.4 21.7 8.5e-53 179.2 21.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) PT-VENN PF04829.13 ORX53988.1 - 0.19 11.9 0.7 0.76 9.9 0.0 2.2 2 0 0 2 2 2 0 Pre-toxin domain with VENN motif RabGAP-TBC PF00566.18 ORX53989.1 - 1.1e-29 103.6 3.9 1e-25 90.7 0.3 2.7 2 1 0 2 2 2 2 Rab-GTPase-TBC domain MAT1-1-2 PF17043.5 ORX53989.1 - 0.079 12.8 0.0 0.24 11.3 0.0 1.8 1 0 0 1 1 1 0 Mating type protein 1-1-2 of unknown function PH PF00169.29 ORX53990.1 - 7e-05 23.3 0.6 0.00051 20.5 0.4 2.4 2 1 0 2 2 2 1 PH domain Myotub-related PF06602.14 ORX53990.1 - 0.094 11.6 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain Peptidase_S24 PF00717.23 ORX53991.1 - 5.9e-11 42.2 0.0 1.2e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Peptidase S24-like Robl_LC7 PF03259.17 ORX53992.1 - 7e-14 51.4 0.0 3.5e-13 49.1 0.0 1.8 1 1 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 ORX53992.1 - 0.00087 19.2 0.0 0.0011 18.9 0.0 1.1 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Glyco_H_20C_C PF18088.1 ORX53993.1 - 1.4e-50 171.9 0.1 2.6e-50 171.0 0.1 1.4 1 0 0 1 1 1 1 Glycoside Hydrolase 20C C-terminal domain Glyco_hydro_20 PF00728.22 ORX53993.1 - 5e-13 49.2 0.0 8.5e-12 45.1 0.0 2.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain zf-C2HC_2 PF13913.6 ORX53994.1 - 0.0029 17.4 1.4 0.0043 16.9 1.4 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type DUF1922 PF09082.10 ORX53994.1 - 0.11 12.8 0.3 0.17 12.2 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) TRAPPC9-Trs120 PF08626.11 ORX53995.1 - 0 1054.0 0.0 0 1053.9 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit TPR_12 PF13424.6 ORX53995.1 - 0.045 14.0 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat NTR PF01759.21 ORX53995.1 - 0.067 13.0 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 UNC-6/NTR/C345C module SOG2 PF10428.9 ORX53995.1 - 0.14 11.4 7.5 0.26 10.5 7.5 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Steroid_dh PF02544.16 ORX53996.1 - 5.7e-28 97.8 4.6 1.9e-26 92.9 0.3 2.2 1 1 1 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 ORX53996.1 - 0.00052 20.4 0.6 0.00052 20.4 0.6 2.6 2 2 1 3 3 3 1 Phospholipid methyltransferase ICMT PF04140.14 ORX53996.1 - 0.0023 18.3 0.2 0.0023 18.3 0.2 2.0 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Macro PF01661.21 ORX53997.1 - 2.6e-18 66.2 0.0 4e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Macro domain RhoGEF PF00621.20 ORX53998.1 - 3.9e-35 121.7 0.4 1e-34 120.3 0.4 1.8 1 0 0 1 1 1 1 RhoGEF domain PH_10 PF15411.6 ORX53998.1 - 9.6e-27 93.7 0.1 2.1e-26 92.6 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 ORX53998.1 - 8.1e-24 83.7 0.1 1.8e-23 82.6 0.1 1.6 1 0 0 1 1 1 1 CDC24 Calponin PB1 PF00564.24 ORX53998.1 - 9.4e-15 54.3 0.4 3e-14 52.7 0.4 1.9 1 0 0 1 1 1 1 PB1 domain PLDc_2 PF13091.6 ORX53999.1 - 2.1e-13 50.3 0.0 1.3e-07 31.5 0.0 2.6 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ORX53999.1 - 0.0037 17.4 1.6 2.5 8.4 0.2 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif COQ7 PF03232.13 ORX53999.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 EcsB PF05975.12 ORX54005.1 - 0.0027 16.6 3.0 0.0039 16.1 3.0 1.2 1 0 0 1 1 1 1 Bacterial ABC transporter protein EcsB DUF2207 PF09972.9 ORX54005.1 - 0.022 13.6 0.4 0.028 13.2 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Erf4 PF10256.9 ORX54005.1 - 0.051 13.7 0.2 0.23 11.5 0.2 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DUF4131 PF13567.6 ORX54005.1 - 2 8.0 6.5 1.3 8.7 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Acyl_transf_1 PF00698.21 ORX54006.1 - 1.9e-26 93.4 0.1 2.9e-26 92.7 0.1 1.2 1 0 0 1 1 1 1 Acyl transferase domain Aldedh PF00171.22 ORX54007.1 - 2e-164 547.5 0.4 2.3e-164 547.3 0.4 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aa_trans PF01490.18 ORX54011.1 - 2.7e-61 207.5 27.7 3.2e-61 207.2 27.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein bZIP_1 PF00170.21 ORX54012.1 - 5.2e-10 39.3 8.3 9.6e-10 38.4 8.3 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX54012.1 - 1.5e-06 28.1 8.7 3.2e-06 27.1 8.7 1.5 1 0 0 1 1 1 1 Basic region leucine zipper Aft1_OSA PF11785.8 ORX54012.1 - 5.3e-05 23.6 2.0 5.3e-05 23.6 2.0 3.4 2 0 0 2 2 2 1 Aft1 osmotic stress response (OSM) domain bZIP_Maf PF03131.17 ORX54012.1 - 0.012 16.1 7.7 0.012 16.1 7.7 1.7 1 1 0 1 1 1 0 bZIP Maf transcription factor HALZ PF02183.18 ORX54012.1 - 0.025 14.8 0.3 0.045 14.0 0.3 1.4 1 0 0 1 1 1 0 Homeobox associated leucine zipper Nnf1 PF03980.14 ORX54012.1 - 0.13 12.6 5.6 0.34 11.3 5.6 1.7 1 0 0 1 1 1 0 Nnf1 ASD2 PF08687.11 ORX54012.1 - 3.4 7.1 14.0 0.12 11.9 7.8 1.7 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 BCDHK_Adom3 PF10436.9 ORX54013.1 - 7.3e-11 42.2 1.3 1.3e-10 41.4 1.3 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Pkinase PF00069.25 ORX54014.1 - 1.1e-67 228.2 0.1 2.1e-67 227.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54014.1 - 3.1e-40 138.1 0.1 6.5e-40 137.0 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54014.1 - 1.5e-06 27.7 0.0 4.7e-06 26.1 0.0 1.8 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ORX54014.1 - 0.03 13.4 0.1 0.059 12.4 0.1 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 YrbL-PhoP_reg PF10707.9 ORX54014.1 - 0.067 12.7 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL CENP-B_dimeris PF09026.10 ORX54014.1 - 0.12 12.7 8.2 0.28 11.6 8.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 ORX54014.1 - 0.17 12.3 3.1 0.46 10.9 3.1 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIE-A_C PF11521.8 ORX54014.1 - 0.42 11.0 6.8 1.4 9.3 6.8 1.9 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Cwf_Cwc_15 PF04889.12 ORX54014.1 - 0.6 9.8 13.7 0.062 13.0 7.5 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF1691 PF07950.11 ORX54015.1 - 1.1e-05 26.1 1.3 0.0069 17.1 0.3 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) Sdh_cyt PF01127.22 ORX54015.1 - 0.12 12.4 6.8 0.099 12.7 4.9 1.8 1 1 1 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1691 PF07950.11 ORX54016.1 - 1.7e-06 28.7 3.1 5.5e-05 23.8 0.5 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1691) DUF1139 PF06599.11 ORX54016.1 - 0.03 13.7 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1139) Myc_target_1 PF15179.6 ORX54019.1 - 3 7.7 5.3 4.6 7.1 5.3 1.2 1 0 0 1 1 1 0 Myc target protein 1 PH PF00169.29 ORX54021.1 - 3.8e-22 78.8 2.1 8.3e-22 77.7 2.1 1.6 1 0 0 1 1 1 1 PH domain SAM_2 PF07647.17 ORX54021.1 - 7.7e-18 64.4 0.0 2.6e-17 62.7 0.0 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX54021.1 - 1.5e-13 50.9 0.0 5.5e-13 49.1 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 ORX54021.1 - 9.7e-13 47.8 0.0 2.4e-12 46.5 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX54021.1 - 6.4e-12 44.9 0.3 1.6e-11 43.7 0.2 1.8 2 0 0 2 2 2 1 SH3 domain PH_11 PF15413.6 ORX54021.1 - 3.2e-09 37.2 7.5 3e-07 30.8 7.5 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.17 ORX54021.1 - 3.7e-09 36.1 0.0 8.6e-09 35.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain CH PF00307.31 ORX54021.1 - 8.4e-07 29.1 0.0 2.5e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 Calponin homology (CH) domain SAM_Ste50p PF09235.10 ORX54021.1 - 0.0032 17.7 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 Ste50p, sterile alpha motif PH_3 PF14593.6 ORX54021.1 - 0.008 16.3 1.0 0.015 15.4 1.0 1.3 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ORX54021.1 - 0.03 14.6 1.3 0.069 13.4 1.3 1.7 1 1 0 1 1 1 0 Pleckstrin homology domain FYRC PF05965.14 ORX54022.1 - 1.1e-05 25.5 0.0 2.9e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 F/Y rich C-terminus Poxvirus_B22R PF04395.12 ORX54022.1 - 0.12 11.9 0.1 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 Poxvirus B22R protein Sld5 PF05916.11 ORX54024.1 - 2.1e-10 41.0 0.0 3.2e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Acetyltransf_1 PF00583.25 ORX54025.1 - 2.3e-09 37.5 0.0 6.8e-09 36.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX54025.1 - 6e-06 26.2 0.1 0.0017 18.3 0.1 2.2 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX54025.1 - 5e-05 23.7 0.0 0.0085 16.5 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX54025.1 - 0.015 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ORX54025.1 - 0.026 14.7 0.0 0.77 9.9 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Calpain_u2 PF16648.5 ORX54025.1 - 0.3 11.6 5.3 0.57 10.7 5.3 1.3 1 0 0 1 1 1 0 Unstructured region on Calpain-3 Alginate_lyase PF05426.12 ORX54026.1 - 5.5e-17 62.2 0.1 5.3e-13 49.1 0.1 2.5 2 0 0 2 2 2 2 Alginate lyase Aa_trans PF01490.18 ORX54027.1 - 1.1e-65 222.0 29.5 1.3e-65 221.8 29.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CcmD PF04995.14 ORX54027.1 - 0.16 12.1 1.3 30 4.8 0.0 3.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Ribonucleas_3_3 PF14622.6 ORX54028.1 - 3e-22 79.2 0.1 3.8e-22 78.8 0.1 1.1 1 0 0 1 1 1 1 Ribonuclease-III-like DUF4297 PF14130.6 ORX54028.1 - 0.0057 16.8 0.0 0.0074 16.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4297) Ribonuclease_3 PF00636.26 ORX54028.1 - 0.0088 16.7 0.0 0.019 15.6 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease III domain zf_CCCH_4 PF18345.1 ORX54029.1 - 7e-07 29.1 2.1 7e-07 29.1 2.1 3.2 3 0 0 3 3 3 1 Zinc finger domain CUE PF02845.16 ORX54029.1 - 9.1e-06 25.3 0.1 1.5e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 CUE domain zf-CCCH_4 PF18044.1 ORX54029.1 - 1.2e-05 25.0 11.3 2.7e-05 23.9 0.8 2.9 2 1 0 2 2 2 1 CCCH-type zinc finger zf-CCCH PF00642.24 ORX54029.1 - 7.7e-05 22.5 7.4 0.00024 20.9 0.2 2.4 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ORX54029.1 - 0.0038 17.9 4.1 0.016 15.9 0.2 2.4 1 1 1 2 2 2 1 Torus domain zf-CCCH_2 PF14608.6 ORX54029.1 - 0.02 15.3 10.8 0.45 11.1 1.0 2.3 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger HBS1_N PF08938.10 ORX54029.1 - 0.035 14.4 0.0 0.069 13.5 0.0 1.4 1 0 0 1 1 1 0 HBS1 N-terminus DUF1296 PF06972.11 ORX54029.1 - 0.072 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) DUF2448 PF10476.9 ORX54029.1 - 0.18 11.7 0.1 17 5.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) zf-CCCH_3 PF15663.5 ORX54029.1 - 0.22 11.8 6.8 0.72 10.1 0.3 2.5 1 1 1 2 2 2 0 Zinc-finger containing family DPBB_1 PF03330.18 ORX54030.1 - 7.7e-08 32.5 0.0 1.2e-07 31.9 0.0 1.4 1 1 0 1 1 1 1 Lytic transglycolase PAS PF00989.25 ORX54031.1 - 0.0016 18.4 0.0 0.0023 17.9 0.0 1.2 1 0 0 1 1 1 1 PAS fold RAP1 PF07218.11 ORX54031.1 - 0.17 10.1 0.0 0.23 9.7 0.0 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) KH_1 PF00013.29 ORX54032.1 - 3.3e-19 68.5 0.4 4.4e-15 55.3 0.4 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 ORX54032.1 - 0.0024 17.7 0.0 0.0061 16.4 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 ORX54032.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.6 1 0 0 1 1 1 0 KH domain WD40 PF00400.32 ORX54033.1 - 1.5e-51 171.2 22.6 1.4e-08 35.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX54033.1 - 2.5e-11 43.7 3.5 0.051 13.9 0.0 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX54033.1 - 8.2e-06 25.8 0.3 8.6e-05 22.5 0.1 2.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX54033.1 - 4.5e-05 22.1 0.1 0.44 9.0 0.1 2.8 2 1 0 2 2 2 2 Cytochrome D1 heme domain DUF1513 PF07433.11 ORX54033.1 - 0.00042 19.5 0.0 0.12 11.4 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 ORX54033.1 - 0.00051 19.1 0.2 0.2 10.6 0.0 3.8 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX54033.1 - 0.0026 16.5 12.9 0.02 13.5 0.2 5.5 4 2 3 7 7 7 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ORX54033.1 - 0.12 12.4 0.0 14 5.8 0.0 2.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region RPAP1_C PF08620.10 ORX54034.1 - 3e-24 84.9 0.2 9.2e-24 83.3 0.1 2.0 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 ORX54034.1 - 2.5e-12 46.4 0.1 4.8e-12 45.4 0.1 1.5 1 0 0 1 1 1 1 RPAP1-like, N-terminal HNH_3 PF13392.6 ORX54035.1 - 0.0016 18.1 0.3 0.012 15.4 0.0 2.2 2 0 0 2 2 2 1 HNH endonuclease CPSase_L_D2 PF02786.17 ORX54036.1 - 2.1e-108 360.7 0.0 1.4e-83 279.6 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 ORX54036.1 - 1.2e-35 122.5 0.1 2.9e-35 121.3 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 ORX54036.1 - 1.2e-16 60.8 0.0 2.8e-08 33.5 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ORX54036.1 - 3e-14 53.0 0.1 3.1e-06 26.9 0.1 2.4 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 ORX54036.1 - 2.6e-11 43.4 0.0 1.8e-05 24.5 0.0 2.8 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.11 ORX54036.1 - 2.4e-06 27.3 0.1 0.0044 16.6 0.0 2.4 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_5 PF13549.6 ORX54036.1 - 0.00017 21.1 0.0 0.0071 15.8 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain GARS_A PF01071.19 ORX54036.1 - 0.0034 17.2 0.0 0.45 10.3 0.0 2.8 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain MGS PF02142.22 ORX54036.1 - 0.043 14.0 0.0 0.32 11.2 0.0 2.4 2 0 0 2 2 2 0 MGS-like domain TrkA_N PF02254.18 ORX54036.1 - 0.087 13.1 0.0 4.5 7.6 0.0 3.0 3 0 0 3 3 3 0 TrkA-N domain Peptidase_M17_N PF02789.17 ORX54036.1 - 0.099 12.5 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain HAD_SAK_1 PF10307.9 ORX54037.1 - 1.8e-51 174.8 0.0 2.7e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins FH2 PF02181.23 ORX54038.1 - 2.8e-80 270.2 2.8 2.8e-80 270.2 2.8 1.7 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ORX54038.1 - 1.5e-30 106.3 0.0 1.5e-30 106.3 0.0 2.7 2 1 1 3 3 3 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ORX54038.1 - 2.2e-27 95.8 2.7 3.1e-27 95.3 0.0 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Hyaluronidase_1 PF07212.11 ORX54038.1 - 0.13 11.5 0.5 0.26 10.5 0.5 1.4 1 0 0 1 1 1 0 Hyaluronidase protein (HylP) NAD_binding_4 PF07993.12 ORX54039.1 - 5.9e-39 133.8 0.0 6e-38 130.5 0.0 2.2 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 ORX54039.1 - 5.6e-30 104.3 0.0 9e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 ORX54039.1 - 6.5e-07 29.6 0.0 1.4e-06 28.6 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ORX54039.1 - 0.0001 21.8 0.0 0.00038 20.0 0.0 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX54039.1 - 0.0051 16.3 0.0 0.017 14.5 0.0 1.8 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ORX54039.1 - 0.0083 16.1 0.0 0.099 12.5 0.0 2.3 2 0 0 2 2 2 1 KR domain AMP-binding_C PF13193.6 ORX54039.1 - 0.032 15.2 0.1 0.09 13.8 0.1 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain NAD_binding_4 PF07993.12 ORX54040.1 - 2.6e-38 131.7 0.0 4.6e-38 130.9 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 ORX54040.1 - 6.4e-34 117.3 0.0 1.2e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 ORX54040.1 - 1.1e-06 28.8 0.1 2.6e-06 27.7 0.1 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 ORX54040.1 - 0.00095 18.7 0.0 0.0039 16.7 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX54040.1 - 0.0039 16.6 0.0 0.009 15.4 0.0 1.6 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ORX54040.1 - 0.12 12.3 0.0 0.29 11.0 0.0 1.7 2 0 0 2 2 2 0 KR domain AMP-binding_C PF13193.6 ORX54040.1 - 0.17 12.9 0.2 0.47 11.5 0.2 1.8 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain OS-D PF03392.13 ORX54040.1 - 0.56 10.3 5.3 0.14 12.3 0.6 2.4 3 0 0 3 3 3 0 Insect pheromone-binding family, A10/OS-D LRR_8 PF13855.6 ORX54041.1 - 3.7e-15 55.4 10.2 7.8e-10 38.4 1.3 3.3 3 1 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 ORX54041.1 - 3.2e-10 40.1 4.5 0.00036 20.8 0.5 3.4 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX54041.1 - 0.016 15.7 5.7 5.6 7.9 0.0 4.6 5 0 0 5 5 5 0 Leucine Rich Repeat Ribosomal_L19e PF01280.20 ORX54042.1 - 6e-62 208.0 10.8 6e-62 208.0 10.8 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e Lant_dehydr_C PF14028.6 ORX54042.1 - 0.0053 16.4 0.2 0.0053 16.4 0.2 1.5 2 0 0 2 2 2 1 Lantibiotic biosynthesis dehydratase C-term Phage_rep_O PF04492.13 ORX54042.1 - 0.064 13.8 1.0 0.25 12.0 0.0 2.2 2 1 0 2 2 2 0 Bacteriophage replication protein O Alpha_TIF PF02232.15 ORX54042.1 - 1.5 7.8 6.0 2.2 7.3 5.7 1.5 1 1 0 1 1 1 0 Alpha trans-inducing protein (Alpha-TIF) SpoIIE PF07228.12 ORX54043.1 - 2.9e-11 43.7 0.0 6.5e-11 42.5 0.0 1.6 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 ORX54043.1 - 5.9e-11 42.5 0.0 3.1e-05 23.8 0.0 2.3 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ORX54043.1 - 3.2e-08 33.5 0.0 8.5e-08 32.1 0.0 1.6 2 0 0 2 2 2 1 Protein phosphatase 2C PWI PF01480.17 ORX54044.1 - 3.6e-12 46.4 0.5 3.6e-12 46.4 0.5 2.3 3 0 0 3 3 3 1 PWI domain Rhodanese PF00581.20 ORX54045.1 - 6.7e-11 42.7 0.0 7.6e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 ORX54046.1 - 1.8e-64 217.6 0.0 2.1e-64 217.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54046.1 - 9.5e-24 84.1 0.0 1.3e-23 83.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54046.1 - 5.3e-07 29.2 0.0 1.1e-05 24.9 0.0 2.4 1 1 1 3 3 3 1 Kinase-like APH PF01636.23 ORX54046.1 - 0.0048 16.8 0.2 0.028 14.3 0.0 2.1 2 1 0 3 3 3 1 Phosphotransferase enzyme family ABC1 PF03109.16 ORX54046.1 - 0.036 14.2 0.0 0.074 13.2 0.0 1.6 1 0 0 1 1 1 0 ABC1 family FTA2 PF13095.6 ORX54046.1 - 0.056 13.1 0.0 0.094 12.3 0.0 1.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 ORX54046.1 - 0.065 12.8 0.0 0.096 12.3 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX54046.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1679 PF07914.11 ORX54046.1 - 0.17 10.7 0.1 0.31 9.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) MCD PF05292.11 ORX54047.1 - 3.4e-70 236.6 0.2 1e-46 159.6 0.0 2.1 1 1 1 2 2 2 2 Malonyl-CoA decarboxylase C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX54048.1 - 8.5e-64 214.6 0.1 1.9e-63 213.4 0.1 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ORX54048.1 - 2.4e-37 127.6 1.2 2.6e-36 124.2 0.3 2.4 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ORX54048.1 - 5.4e-29 100.2 0.0 1.1e-28 99.2 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_binding_2 PF03446.15 ORX54048.1 - 0.0058 16.8 0.0 0.11 12.6 0.0 2.6 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 ORX54048.1 - 0.025 14.8 0.2 0.16 12.2 0.0 2.3 1 1 2 3 3 3 0 Saccharopine dehydrogenase NADP binding domain ParA PF10609.9 ORX54049.1 - 3.1e-72 243.0 0.0 3.5e-72 242.8 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase zf-C4_ClpX PF06689.13 ORX54049.1 - 0.055 13.4 1.0 0.1 12.5 1.0 1.4 1 0 0 1 1 1 0 ClpX C4-type zinc finger UPF0242 PF06785.11 ORX54050.1 - 0.0006 20.0 28.2 0.0013 18.8 28.2 1.6 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 ORX54050.1 - 1.3 8.5 29.0 1.8 8.1 29.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SMN PF06003.12 ORX54050.1 - 1.7 7.8 12.0 3.2 6.9 12.0 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) VIT1 PF01988.19 ORX54052.1 - 2.1e-73 246.7 0.1 2.4e-73 246.5 0.1 1.0 1 0 0 1 1 1 1 VIT family SLATT_fungal PF18142.1 ORX54052.1 - 0.014 15.3 0.1 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 7TMR-DISM_7TM PF07695.11 ORX54052.1 - 0.018 15.0 0.6 0.033 14.1 0.6 1.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling DUF2207 PF09972.9 ORX54052.1 - 0.16 10.7 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3792 PF12670.7 ORX54052.1 - 0.29 11.3 13.7 3.1 8.0 8.3 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3792) Metal_resist PF13801.6 ORX54053.1 - 0.01 16.0 0.6 0.025 14.8 0.6 1.6 1 0 0 1 1 1 0 Heavy-metal resistance CTK3 PF12243.8 ORX54054.1 - 6.9e-34 116.5 0.2 1e-33 116.0 0.2 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 ORX54054.1 - 4.5e-11 42.7 4.5 5.1e-11 42.6 2.9 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus CTD_bind PF04818.13 ORX54054.1 - 0.00025 21.8 0.0 0.00063 20.5 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Arrestin_C PF02752.22 ORX54055.1 - 2.2e-16 60.5 0.1 1.8e-13 51.1 0.0 2.1 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX54055.1 - 1.5e-15 57.5 0.0 2.6e-15 56.8 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX54055.1 - 0.00046 20.0 0.0 0.00067 19.4 0.0 1.2 1 0 0 1 1 1 1 Arrestin_N terminal like Exo_endo_phos PF03372.23 ORX54056.1 - 5.7e-06 26.0 0.0 1.6e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YhfZ_C PF14503.6 ORX54056.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 YhfZ C-terminal domain Sterol-sensing PF12349.8 ORX54057.1 - 9.6e-30 103.4 6.5 8.7e-29 100.3 4.6 2.3 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ORX54057.1 - 1.4e-14 53.2 1.1 2.1e-14 52.6 1.1 1.2 1 0 0 1 1 1 1 Patched family WD40 PF00400.32 ORX54057.1 - 0.011 16.5 12.3 1.1 10.2 0.6 5.4 4 1 0 4 4 4 0 WD domain, G-beta repeat GTP_EFTU PF00009.27 ORX54060.1 - 1.3e-55 188.0 0.0 2.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX54060.1 - 7.2e-42 142.2 0.0 1.5e-41 141.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX54060.1 - 1.7e-14 53.9 1.2 1.7e-14 53.9 1.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX54060.1 - 0.00066 19.8 0.1 0.014 15.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DSPc PF00782.20 ORX54061.1 - 9.1e-08 32.0 0.0 1.2e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX54061.1 - 1.2e-05 25.0 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ORX54061.1 - 0.00033 20.4 0.1 0.00044 20.0 0.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 ORX54061.1 - 0.1 12.7 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate CENP-F_leu_zip PF10473.9 ORX54062.1 - 0.0071 16.4 8.1 0.0071 16.4 8.1 3.6 3 1 0 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliD_N PF02465.18 ORX54062.1 - 0.0077 16.9 0.3 0.0077 16.9 0.3 4.7 3 1 1 4 4 4 1 Flagellar hook-associated protein 2 N-terminus RBD-FIP PF09457.10 ORX54062.1 - 0.0099 15.8 0.9 0.0099 15.8 0.9 2.6 2 0 0 2 2 2 1 FIP domain COMP PF11598.8 ORX54062.1 - 0.25 11.8 0.3 0.25 11.8 0.3 2.7 3 0 0 3 3 1 0 Cartilage oligomeric matrix protein APG6_N PF17675.1 ORX54062.1 - 0.31 11.6 39.3 0.056 14.0 4.7 3.4 3 0 0 3 3 3 0 Apg6 coiled-coil region Fez1 PF06818.15 ORX54062.1 - 0.31 11.4 32.7 0.38 11.2 13.6 2.4 2 0 0 2 2 2 0 Fez1 WD40_alt PF14077.6 ORX54062.1 - 1.1 9.2 4.2 28 4.7 0.1 3.3 3 0 0 3 3 3 0 Alternative WD40 repeat motif DUF3450 PF11932.8 ORX54062.1 - 3.2 7.0 39.2 0.28 10.5 5.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) LMBR1 PF04791.16 ORX54062.1 - 3.5 6.4 23.5 0.62 8.9 7.7 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF641 PF04859.12 ORX54062.1 - 4.8 7.5 29.7 0.91 9.9 2.4 4.1 3 1 1 4 4 4 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 ORX54062.1 - 9.2 6.3 46.7 0.8 9.8 15.3 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus QRPTase_C PF01729.19 ORX54063.1 - 9.8e-56 188.1 0.1 1.2e-55 187.9 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 ORX54063.1 - 2.4e-19 69.2 0.0 5e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain NAD_binding_10 PF13460.6 ORX54063.1 - 0.077 12.9 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 NAD(P)H-binding DUF3856 PF12968.7 ORX54063.1 - 0.085 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) XLF PF09302.11 ORX54064.1 - 2.8e-13 50.4 0.0 2.8e-13 50.4 0.0 2.0 2 1 0 2 2 2 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Usp PF00582.26 ORX54066.1 - 6.6e-17 62.3 0.1 9.8e-17 61.8 0.1 1.4 1 1 0 1 1 1 1 Universal stress protein family GrpE PF01025.19 ORX54066.1 - 0.022 14.5 0.1 0.028 14.1 0.1 1.2 1 0 0 1 1 1 0 GrpE DUF3848 PF12959.7 ORX54066.1 - 0.07 13.2 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) Phage_holin_6_1 PF09682.10 ORX54066.1 - 0.075 13.5 0.2 0.11 12.9 0.2 1.3 1 0 0 1 1 1 0 Bacteriophage holin of superfamily 6 (Holin_LLH) B12D PF06522.11 ORX54067.1 - 3.1e-19 68.5 0.1 3.8e-19 68.3 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit NPBW PF15180.6 ORX54067.1 - 0.06 13.2 0.0 0.068 13.0 0.0 1.2 1 0 0 1 1 1 0 Neuropeptides B and W DcuC PF03606.15 ORX54067.1 - 0.088 11.2 0.0 0.095 11.1 0.0 1.0 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier HLH PF00010.26 ORX54068.1 - 0.098 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Striatin PF08232.12 ORX54069.1 - 7.9e-45 153.2 7.0 7.9e-45 153.2 7.0 3.0 3 0 0 3 3 3 1 Striatin family WD40 PF00400.32 ORX54069.1 - 1.4e-36 123.8 9.0 1e-07 32.5 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX54069.1 - 1.4e-13 50.9 0.1 0.0016 18.7 0.1 4.2 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ORX54069.1 - 6.2e-05 22.7 0.2 0.00036 20.2 0.1 2.1 1 1 1 2 2 2 1 PQQ-like domain PQQ PF01011.21 ORX54069.1 - 0.035 14.1 0.2 7.4 6.7 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5046 PF16465.5 ORX54069.1 - 0.067 12.6 0.2 0.17 11.3 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5046) Ge1_WD40 PF16529.5 ORX54069.1 - 0.19 10.6 1.7 11 4.8 0.0 3.5 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4843 PF16132.5 ORX54070.1 - 1.7 8.2 4.2 4.1 6.9 4.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4843) LCAT PF02450.15 ORX54072.1 - 2.9e-82 276.9 0.0 7.8e-82 275.5 0.0 1.6 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF5106 PF17127.4 ORX54072.1 - 0.062 13.6 0.3 0.29 11.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) Hydrolase_4 PF12146.8 ORX54072.1 - 0.17 11.1 0.0 0.32 10.2 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ank_3 PF13606.6 ORX54073.1 - 1.3e-13 49.7 0.0 0.0029 18.0 0.0 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 ORX54073.1 - 3.7e-13 49.8 0.3 1e-11 45.3 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX54073.1 - 2.4e-11 43.6 0.5 1.4e-07 31.6 0.5 4.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX54073.1 - 1.1e-09 38.6 0.0 0.00031 21.2 0.0 3.1 1 1 3 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX54073.1 - 1.6e-09 37.8 0.0 0.015 15.7 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat 2-ph_phosp PF04029.14 ORX54073.1 - 0.024 13.8 0.2 0.042 13.0 0.2 1.3 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase SBDS PF01172.18 ORX54073.1 - 0.11 12.6 0.0 0.3 11.2 0.0 1.6 2 0 0 2 2 2 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein bZIP_1 PF00170.21 ORX54074.1 - 1.5e-06 28.1 10.4 7e-06 26.1 10.4 2.1 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX54074.1 - 0.0099 15.9 5.7 0.0099 15.9 5.7 2.7 3 0 0 3 3 3 1 Basic region leucine zipper SPX PF03105.19 ORX54074.1 - 6.9 6.5 34.1 3.5 7.5 13.5 2.1 1 1 1 2 2 2 0 SPX domain Pho88 PF10032.9 ORX54075.1 - 5.4e-53 179.0 0.2 5.9e-53 178.8 0.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) TM140 PF14985.6 ORX54075.1 - 0.062 12.8 0.2 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 TM140 protein family DUF3817 PF12823.7 ORX54075.1 - 0.54 11.1 3.4 20 6.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) TALPID3 PF15324.6 ORX54076.1 - 0.099 10.3 5.0 0.094 10.4 5.0 1.0 1 0 0 1 1 1 0 Hedgehog signalling target PLRV_ORF5 PF01690.17 ORX54076.1 - 4.3 5.9 8.9 5.2 5.7 8.9 1.2 1 0 0 1 1 1 0 Potato leaf roll virus readthrough protein FAM60A PF15396.6 ORX54077.1 - 0.13 12.2 6.4 0.17 11.9 6.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Kelch_4 PF13418.6 ORX54078.1 - 4.8e-11 42.5 10.7 1.3e-05 25.1 1.1 5.1 4 2 0 4 4 4 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX54078.1 - 1.2e-09 37.9 5.4 0.0014 18.5 0.1 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ORX54078.1 - 6.5e-08 32.7 15.9 2.5e-05 24.4 0.9 4.4 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX54078.1 - 2.2e-07 30.9 13.4 0.00037 20.7 0.7 5.1 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ORX54078.1 - 1e-05 25.0 9.1 7e-05 22.3 0.2 4.3 4 1 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ORX54078.1 - 0.00039 20.3 2.7 0.032 14.2 0.3 3.8 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ORX54079.1 - 0.21 11.6 7.5 5.6 7.1 0.1 3.6 4 0 0 4 4 4 0 Kelch motif LEA_2 PF03168.13 ORX54080.1 - 9.5e-05 22.9 0.2 0.00054 20.4 0.1 2.0 2 0 0 2 2 2 1 Late embryogenesis abundant protein Dymeclin PF09742.9 ORX54081.1 - 2.1e-104 350.2 24.7 2.6e-104 349.9 24.7 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Hid1 PF12722.7 ORX54081.1 - 3.1e-06 25.6 24.1 0.018 13.2 0.0 4.1 2 1 1 3 3 3 3 High-temperature-induced dauer-formation protein DUF5559 PF17714.1 ORX54082.1 - 0.42 10.5 5.6 0.34 10.8 1.4 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5559) Yippee-Mis18 PF03226.14 ORX54083.1 - 2.7e-14 53.2 1.0 3.6e-14 52.9 1.0 1.0 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Cytochrom_CIII PF02085.16 ORX54083.1 - 0.0022 18.3 2.1 0.0082 16.5 2.0 1.7 1 1 0 1 1 1 1 Class III cytochrome C family RIG-I_C-RD PF11648.8 ORX54083.1 - 0.0024 18.1 0.6 0.003 17.8 0.6 1.1 1 0 0 1 1 1 1 C-terminal domain of RIG-I Cytochrom_c3_2 PF14537.6 ORX54083.1 - 0.022 15.2 3.2 0.31 11.5 4.2 2.0 1 1 1 2 2 2 0 Cytochrome c3 Cytochrome_C7 PF14522.6 ORX54083.1 - 0.029 14.4 6.4 0.37 10.8 6.4 2.2 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c zf_UBZ PF18439.1 ORX54083.1 - 0.033 13.8 1.1 1 9.0 0.1 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger GFA PF04828.14 ORX54083.1 - 0.042 14.2 2.1 0.34 11.3 0.2 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Cytochrome_C554 PF13435.6 ORX54083.1 - 0.11 13.5 0.6 0.11 13.5 0.6 2.2 1 1 1 2 2 2 0 Cytochrome c554 and c-prime zf-HIT PF04438.16 ORX54083.1 - 0.18 11.7 2.5 2.5 8.1 0.5 2.3 2 0 0 2 2 2 0 HIT zinc finger DZR PF12773.7 ORX54083.1 - 0.37 10.8 3.1 5 7.2 3.2 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RRN7 PF11781.8 ORX54083.1 - 0.5 10.1 9.9 1.6 8.5 0.8 2.6 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Cytochrome_CBB3 PF13442.6 ORX54083.1 - 1.3 9.4 6.1 9.3 6.7 1.3 2.3 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III zf-CHY PF05495.12 ORX54083.1 - 1.4 9.5 6.4 14 6.3 6.5 2.1 1 1 1 2 2 2 0 CHY zinc finger Abhydrolase_3 PF07859.13 ORX54084.1 - 4.9e-27 95.2 0.0 7.4e-27 94.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX54084.1 - 8.2e-10 38.1 0.0 1.7e-08 33.8 0.0 2.2 1 1 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX54084.1 - 0.014 14.8 0.0 0.036 13.5 0.0 1.6 1 0 0 1 1 1 0 Prolyl oligopeptidase family STIMATE PF12400.8 ORX54085.1 - 1.1e-36 126.1 7.8 1.8e-36 125.4 7.8 1.3 1 0 0 1 1 1 1 STIMATE family DUF4271 PF14093.6 ORX54085.1 - 0.67 9.8 11.9 0.74 9.7 8.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) DEAD PF00270.29 ORX54086.1 - 1.8e-42 145.1 0.0 4.5e-42 143.8 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX54086.1 - 2e-21 76.4 0.0 4.6e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX54086.1 - 5.9e-11 42.7 0.0 1.2e-10 41.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 ORX54086.1 - 0.00013 20.8 0.0 0.00019 20.3 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_19 PF13245.6 ORX54086.1 - 0.0015 18.9 0.0 0.016 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX54086.1 - 0.0026 18.0 0.1 0.58 10.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 ORX54086.1 - 0.0032 17.2 0.0 0.0071 16.0 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Flavi_DEAD PF07652.14 ORX54086.1 - 0.032 14.2 0.2 0.11 12.4 0.1 1.9 2 0 0 2 2 2 0 Flavivirus DEAD domain Na_Ca_ex PF01699.24 ORX54087.1 - 6.4e-17 61.9 25.0 2.8e-12 46.8 2.7 3.6 4 1 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 ORX54087.1 - 2.9e-13 50.3 10.6 2.9e-13 50.3 10.6 4.1 3 0 0 3 3 3 1 Inner membrane component domain TRAM_LAG1_CLN8 PF03798.16 ORX54088.1 - 4.2e-38 131.1 33.9 4.8e-38 130.9 26.6 2.1 2 0 0 2 2 2 2 TLC domain TRAM1 PF08390.11 ORX54088.1 - 6.8e-19 67.3 0.2 6.8e-19 67.3 0.2 2.6 3 0 0 3 3 3 1 TRAM1-like protein TauD PF02668.16 ORX54089.1 - 1.3e-29 103.8 0.1 1.8e-29 103.4 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family CsiD PF08943.10 ORX54089.1 - 1.6e-05 24.2 0.1 2.6e-05 23.5 0.1 1.2 1 0 0 1 1 1 1 CsiD ArenaCapSnatch PF17296.2 ORX54089.1 - 0.12 11.7 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Arenavirus cap snatching domain F-box PF00646.33 ORX54090.1 - 0.0015 18.4 0.3 0.0047 16.8 0.3 1.9 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX54090.1 - 0.002 18.0 1.1 0.002 18.0 1.1 2.1 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ORX54090.1 - 4.3 7.9 12.4 5.7 7.5 0.6 5.2 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) IGR PF09597.10 ORX54093.1 - 0.042 14.0 0.5 10 6.3 0.0 3.4 1 1 2 3 3 3 0 IGR protein motif ANAPC4 PF12896.7 ORX54093.1 - 0.19 11.2 0.0 7.7 6.0 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 FSA_C PF10479.9 ORX54094.1 - 0.33 9.0 6.7 0.48 8.5 6.7 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Apolipoprotein PF01442.18 ORX54096.1 - 4.8e-08 33.1 51.5 6.3e-05 22.9 19.8 3.5 1 1 2 3 3 3 3 Apolipoprotein A1/A4/E domain YtxH PF12732.7 ORX54096.1 - 2.3e-07 31.2 55.8 0.043 14.4 4.0 9.1 2 1 4 6 6 6 4 YtxH-like protein DUF883 PF05957.13 ORX54096.1 - 0.00029 21.4 69.0 0.037 14.6 5.2 7.2 1 1 6 8 8 8 5 Bacterial protein of unknown function (DUF883) ApoLp-III PF07464.11 ORX54096.1 - 0.0072 16.4 39.2 0.048 13.8 10.4 5.2 3 1 2 5 5 5 3 Apolipophorin-III precursor (apoLp-III) V-SNARE PF05008.15 ORX54096.1 - 0.13 12.6 19.3 0.73 10.3 0.6 4.8 4 1 1 5 5 5 0 Vesicle transport v-SNARE protein N-terminus SHR3_chaperone PF08229.11 ORX54096.1 - 1.1 8.2 0.0 1.1 8.2 0.0 3.6 4 0 0 4 4 4 0 ER membrane protein SH3 GerPC PF10737.9 ORX54096.1 - 6.7 6.7 18.4 0.26 11.3 2.9 3.4 1 1 1 3 3 3 0 Spore germination protein GerPC Gln-synt_C PF00120.24 ORX54097.1 - 1.6e-20 73.4 0.0 4e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ORX54097.1 - 2.8e-12 46.2 0.0 5e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain PIG-P PF08510.12 ORX54099.1 - 8.1e-39 132.3 9.9 9.9e-39 132.0 9.9 1.1 1 0 0 1 1 1 1 PIG-P DUF5084 PF16894.5 ORX54099.1 - 0.037 14.5 4.2 0.055 13.9 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5084) DPM2 PF07297.12 ORX54099.1 - 0.53 10.6 13.1 0.99 9.8 13.1 1.4 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF485 PF04341.12 ORX54099.1 - 0.91 9.5 7.3 4.7 7.2 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF485 Rab5ip PF07019.12 ORX54099.1 - 3.5 8.3 10.9 5.4 7.7 10.9 1.2 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) WD40 PF00400.32 ORX54101.1 - 7.2e-06 26.6 10.5 0.038 14.9 0.2 5.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX54101.1 - 9.1e-05 22.7 3.6 0.064 13.6 0.1 4.2 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Prp18 PF02840.15 ORX54101.1 - 0.024 14.7 0.3 0.055 13.5 0.3 1.6 1 0 0 1 1 1 0 Prp18 domain TRIQK PF15168.6 ORX54102.1 - 0.11 12.4 0.4 0.19 11.6 0.4 1.4 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Pkinase PF00069.25 ORX54103.1 - 1.2e-12 47.8 0.3 1.4e-12 47.5 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 ORX54103.1 - 1.8e-12 47.3 0.2 5.6e-12 45.7 0.0 1.7 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 ORX54103.1 - 3.2e-12 46.2 0.0 5.3e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX54103.1 - 6.1e-09 36.2 0.0 6.7e-06 26.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ORX54103.1 - 9.9e-09 34.9 0.9 1.6e-08 34.2 0.2 1.6 1 1 0 2 2 2 1 Protein tyrosine kinase Choline_kinase PF01633.20 ORX54103.1 - 1.7e-05 24.5 0.0 2.9e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 Choline/ethanolamine kinase EcKinase PF02958.20 ORX54103.1 - 0.0012 18.2 0.1 0.0018 17.7 0.1 1.3 1 1 0 1 1 1 1 Ecdysteroid kinase Fructosamin_kin PF03881.14 ORX54103.1 - 0.0054 16.0 0.0 0.0062 15.8 0.0 1.3 1 0 0 1 1 1 1 Fructosamine kinase PI3_PI4_kinase PF00454.27 ORX54103.1 - 0.0095 15.8 0.2 0.05 13.4 0.1 2.0 1 1 1 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Kinase-like PF14531.6 ORX54103.1 - 0.0098 15.2 0.1 0.02 14.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like WaaY PF06176.11 ORX54103.1 - 0.028 14.0 0.1 0.033 13.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) Seadorna_VP7 PF07387.11 ORX54103.1 - 0.033 13.3 0.2 0.045 12.8 0.2 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 OTCace PF00185.24 ORX54105.1 - 2.7e-50 170.5 0.1 4.2e-50 169.9 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ORX54105.1 - 1.1e-46 158.5 0.1 1.8e-46 157.8 0.1 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Glyco_hydro_4 PF02056.16 ORX54105.1 - 0.0034 17.0 0.3 0.0061 16.1 0.3 1.3 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase OCD_Mu_crystall PF02423.15 ORX54105.1 - 0.069 12.1 0.3 0.12 11.3 0.3 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family 4HBT PF03061.22 ORX54106.1 - 0.00056 20.2 0.0 0.0074 16.6 0.0 2.3 2 0 0 2 2 2 1 Thioesterase superfamily BBS2_Mid PF14783.6 ORX54107.1 - 0.013 15.6 0.0 0.56 10.3 0.0 2.3 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Mito_fiss_Elm1 PF06258.11 ORX54107.1 - 0.18 10.9 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 Pkinase PF00069.25 ORX54109.1 - 6.3e-45 153.6 0.0 8.4e-45 153.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54109.1 - 8.9e-29 100.5 0.0 1.1e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX54109.1 - 0.0058 16.6 0.2 1.9 8.3 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX54109.1 - 0.0085 15.4 0.0 0.012 14.9 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX54109.1 - 0.016 14.2 0.0 0.059 12.3 0.1 1.8 2 0 0 2 2 2 0 Haspin like kinase domain Sec20 PF03908.13 ORX54109.1 - 0.048 13.6 0.0 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 Sec20 Kdo PF06293.14 ORX54109.1 - 0.071 12.5 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CBS PF00571.28 ORX54110.1 - 2.4e-18 66.3 0.4 0.00013 22.4 0.0 4.7 4 1 0 4 4 4 4 CBS domain HopJ PF08888.11 ORX54110.1 - 0.094 13.0 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 HopJ type III effector protein HAUS-augmin3 PF14932.6 ORX54110.1 - 0.16 11.5 0.1 0.26 10.9 0.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 AHL_synthase PF17327.2 ORX54110.1 - 0.18 10.8 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Acyl homoserine lactone synthase DEAD PF00270.29 ORX54111.1 - 1.1e-47 162.1 0.1 2.1e-47 161.2 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX54111.1 - 2.8e-24 85.6 0.0 3.6e-23 82.0 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX54111.1 - 4.1e-20 71.8 0.2 7.5e-20 70.9 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX54111.1 - 0.0001 22.3 0.3 0.00021 21.3 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ArgoL2 PF16488.5 ORX54111.1 - 0.13 12.6 0.3 23 5.4 0.1 3.5 3 0 0 3 3 3 0 Argonaute linker 2 domain Phos_pyr_kin PF08543.12 ORX54113.1 - 1.1e-88 296.8 3.6 1.6e-88 296.2 3.6 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 ORX54113.1 - 2.9e-47 161.2 0.1 8.7e-47 159.6 0.0 1.7 2 0 0 2 2 2 1 TENA/THI-4/PQQC family PfkB PF00294.24 ORX54113.1 - 1.7e-07 30.8 0.1 4.2e-07 29.6 0.1 1.6 1 1 0 1 1 1 1 pfkB family carbohydrate kinase HK PF02110.15 ORX54113.1 - 0.00013 21.5 0.4 0.45 9.9 0.1 2.4 2 0 0 2 2 2 2 Hydroxyethylthiazole kinase family Carb_kinase PF01256.17 ORX54113.1 - 0.00071 19.1 3.6 0.0035 16.8 3.6 2.1 1 1 0 1 1 1 1 Carbohydrate kinase Mus7 PF09462.10 ORX54114.1 - 0.00022 20.2 0.2 0.00022 20.2 0.2 1.9 1 1 1 2 2 2 1 Mus7/MMS22 family DUF4210 PF13915.6 ORX54115.1 - 9.6e-22 77.4 0.2 3e-21 75.8 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 ORX54115.1 - 1.5e-12 47.4 0.5 3e-12 46.5 0.5 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis E1-E2_ATPase PF00122.20 ORX54116.1 - 4.6e-52 176.2 3.1 8.5e-52 175.3 0.0 2.9 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX54116.1 - 1e-51 175.2 2.6 1e-51 175.2 2.6 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX54116.1 - 3.9e-21 76.3 0.1 1.6e-20 74.3 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX54116.1 - 5.8e-16 58.3 0.0 1.3e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX54116.1 - 9.5e-16 57.3 0.1 2e-15 56.2 0.1 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX54116.1 - 5.4e-05 23.0 3.4 0.0015 18.3 1.7 2.4 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2127 PF09900.9 ORX54116.1 - 0.01 16.1 1.0 0.044 14.0 1.0 2.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2127) MWFE PF15879.5 ORX54116.1 - 0.034 14.3 0.0 0.49 10.6 0.0 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DAGK_cat PF00781.24 ORX54116.1 - 0.091 12.4 0.0 0.26 10.9 0.0 1.8 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF3784 PF12650.7 ORX54116.1 - 0.16 12.2 0.1 0.16 12.2 0.1 3.9 5 0 0 5 5 5 0 Domain of unknown function (DUF3784) HK PF02110.15 ORX54117.1 - 8.6e-79 264.4 4.5 1.4e-78 263.7 4.5 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 ORX54117.1 - 6.4e-63 211.4 4.3 6.8e-63 211.3 0.2 2.5 3 0 0 3 3 3 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 ORX54117.1 - 0.00058 19.4 0.9 0.0012 18.4 0.9 1.4 1 0 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 ORX54117.1 - 0.004 16.6 0.2 0.0075 15.7 0.2 1.5 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Tetraspanin PF00335.20 ORX54117.1 - 0.082 12.6 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Tetraspanin family Fer2_3 PF13085.6 ORX54118.1 - 3.6e-33 113.8 0.0 5.8e-33 113.2 0.0 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 ORX54118.1 - 2e-09 37.9 7.4 2e-09 37.9 7.4 2.1 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 ORX54118.1 - 1.6e-07 31.7 11.6 2.7e-07 30.9 8.6 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 ORX54118.1 - 1.5e-06 28.2 3.4 1.5e-06 28.2 3.4 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 ORX54118.1 - 0.00078 20.0 5.0 0.00078 20.0 5.0 2.4 2 2 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 ORX54118.1 - 0.0085 16.0 0.3 0.0085 16.0 0.3 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain DNA_pol3_tau_4 PF12168.8 ORX54118.1 - 0.071 13.7 0.3 0.071 13.7 0.3 1.6 2 0 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Fer4_9 PF13187.6 ORX54118.1 - 0.19 11.9 13.0 0.037 14.2 7.2 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 ORX54118.1 - 0.41 10.8 5.0 0.6 10.3 0.1 2.5 3 0 0 3 3 3 0 4Fe-4S dicluster domain ECR1_N PF14382.6 ORX54119.1 - 4e-16 58.5 0.5 7.3e-16 57.7 0.5 1.5 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 ORX54119.1 - 1.7e-13 50.7 0.1 4.2e-13 49.4 0.1 1.8 1 0 0 1 1 1 1 KH domain S1 PF00575.23 ORX54119.1 - 0.012 16.0 0.0 0.86 10.0 0.0 2.7 2 0 0 2 2 2 0 S1 RNA binding domain EXOSC1 PF10447.9 ORX54119.1 - 0.015 15.9 0.2 0.39 11.4 0.1 2.4 1 1 1 2 2 2 0 Exosome component EXOSC1/CSL4 WH2 PF02205.20 ORX54121.1 - 3.2e-08 33.1 2.7 9.1e-08 31.7 1.1 2.3 2 0 0 2 2 2 1 WH2 motif UPF0121 PF03661.13 ORX54122.1 - 5.1e-33 114.5 16.8 5.8e-33 114.3 16.8 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) MOZ_SAS PF01853.18 ORX54122.1 - 0.052 13.2 0.4 0.052 13.2 0.4 1.8 2 0 0 2 2 2 0 MOZ/SAS family PIG-P PF08510.12 ORX54122.1 - 1 9.3 6.9 14 5.6 6.9 2.3 1 1 0 1 1 1 0 PIG-P cNMP_binding PF00027.29 ORX54123.1 - 3.5e-34 116.7 0.0 3e-19 68.9 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain LRR_6 PF13516.6 ORX54123.1 - 2e-13 49.2 14.2 0.21 11.8 0.4 9.5 10 0 0 10 10 10 5 Leucine Rich repeat LRR_4 PF12799.7 ORX54123.1 - 2.7e-08 34.0 7.8 0.16 12.4 0.1 5.8 5 1 0 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX54123.1 - 0.044 14.3 21.2 76 4.5 0.3 9.0 9 2 1 10 10 10 0 Leucine Rich Repeat F-box PF00646.33 ORX54123.1 - 0.063 13.2 2.2 0.088 12.7 0.4 2.4 2 0 0 2 2 2 0 F-box domain F-box_4 PF15966.5 ORX54123.1 - 0.11 12.4 0.7 0.46 10.4 0.1 2.4 3 0 0 3 3 3 0 F-box 6PF2K PF01591.18 ORX54124.1 - 2.9e-49 167.4 2.7 4.3e-31 108.0 3.9 2.1 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX54124.1 - 1e-28 100.4 0.0 3.5e-28 98.6 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ORX54124.1 - 0.019 15.1 0.0 0.062 13.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain GerPC PF10737.9 ORX54124.1 - 0.024 14.7 1.0 0.024 14.7 1.0 1.7 2 0 0 2 2 2 0 Spore germination protein GerPC Sad1_UNC PF07738.13 ORX54126.1 - 4.2e-26 91.5 0.0 1.5e-25 89.7 0.0 1.9 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal PITH PF06201.13 ORX54126.1 - 0.049 13.8 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 PITH domain SKA2 PF16740.5 ORX54126.1 - 0.11 12.3 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 PDZ_5 PF17817.1 ORX54127.1 - 0.012 15.9 0.6 0.037 14.3 0.1 1.9 2 0 0 2 2 2 0 PDZ domain Pkinase PF00069.25 ORX54128.1 - 1.3e-55 188.6 0.0 2.4e-38 132.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54128.1 - 9.5e-24 84.1 0.0 1.7e-23 83.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54128.1 - 2.2e-07 30.5 0.0 3.1e-05 23.5 0.0 2.4 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX54128.1 - 1.5e-05 25.1 0.2 2.1e-05 24.6 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX54128.1 - 0.00022 20.7 0.0 0.00039 19.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX54128.1 - 0.01 14.8 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 ORX54128.1 - 0.018 14.6 0.1 0.029 13.9 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase TM1506 PF08973.10 ORX54128.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) TTC5_OB PF16669.5 ORX54128.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain Pkinase_fungal PF17667.1 ORX54128.1 - 0.14 10.9 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Ribosomal_L5e PF17144.4 ORX54129.1 - 2e-85 284.8 0.1 3.4e-85 284.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 ORX54129.1 - 1.2e-30 106.2 4.4 1.2e-30 106.2 4.4 2.1 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Sorting_nexin PF03700.13 ORX54129.1 - 0.062 13.9 0.1 0.1 13.1 0.1 1.3 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain Nop53 PF07767.11 ORX54130.1 - 2.3 7.5 25.6 2.6 7.3 25.6 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Myb_DNA-binding PF00249.31 ORX54131.1 - 1.2e-42 143.9 9.6 1.6e-16 60.2 0.1 3.2 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX54131.1 - 3.6e-36 123.2 7.2 1.7e-15 57.0 0.0 3.3 1 1 2 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 ORX54131.1 - 6.5e-07 29.4 0.1 0.086 12.9 0.0 3.8 1 1 2 4 4 4 2 SLIDE Myb_DNA-bind_7 PF15963.5 ORX54131.1 - 8e-05 22.5 0.3 0.3 11.0 0.6 2.5 2 0 0 2 2 2 2 Myb DNA-binding like Myb_DNA-bind_4 PF13837.6 ORX54131.1 - 0.0036 17.7 12.4 1.9 8.9 3.6 4.1 2 2 1 3 3 3 2 Myb/SANT-like DNA-binding domain Rap1_C PF11626.8 ORX54131.1 - 0.0056 16.8 0.0 3.9 7.6 0.0 3.0 1 1 2 3 3 3 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain MADF_DNA_bdg PF10545.9 ORX54131.1 - 0.042 14.2 6.5 1.1 9.6 1.4 3.1 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Spore_III_AB PF09548.10 ORX54131.1 - 0.054 13.6 0.3 0.1 12.7 0.1 1.6 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Myb_DNA-bind_5 PF13873.6 ORX54131.1 - 1.7 8.7 7.7 37 4.5 0.0 4.4 5 1 0 5 5 5 0 Myb/SANT-like DNA-binding domain Tox-REase-7 PF15649.6 ORX54132.1 - 0.08 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 7 Pkinase PF00069.25 ORX54133.1 - 1.7e-66 224.3 0.0 2.3e-66 223.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54133.1 - 1.9e-34 119.1 0.0 2.7e-34 118.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54133.1 - 7.5e-08 32.0 0.0 1.1e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX54133.1 - 0.00014 20.8 0.9 0.00032 19.6 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ORX54133.1 - 0.0065 15.8 1.1 0.013 14.8 1.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX54133.1 - 0.0082 16.1 1.6 0.016 15.2 1.6 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ORX54133.1 - 0.1 12.1 0.0 0.1 12.1 0.0 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL VPS9 PF02204.18 ORX54134.1 - 1.3e-17 63.9 0.0 4.7e-17 62.1 0.0 2.0 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain Ank_2 PF12796.7 ORX54134.1 - 1e-11 45.3 0.4 1.7e-05 25.3 0.1 5.4 3 1 3 6 6 6 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX54134.1 - 3.1e-10 40.4 2.2 0.34 11.5 0.0 6.1 5 1 1 6 6 6 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX54134.1 - 1.9e-09 37.6 0.9 0.041 14.2 0.2 5.7 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX54134.1 - 1.6e-05 24.9 1.2 0.16 12.6 0.0 5.0 6 0 0 6 6 6 1 Ankyrin repeat Ank PF00023.30 ORX54134.1 - 0.0033 17.8 8.6 3.4 8.3 0.0 5.5 6 1 0 6 6 6 2 Ankyrin repeat PX PF00787.24 ORX54134.1 - 0.033 14.2 1.7 0.16 12.0 1.7 2.2 1 1 0 1 1 1 0 PX domain G-alpha PF00503.20 ORX54135.1 - 5e-114 381.2 6.0 6.2e-114 380.8 6.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX54135.1 - 5.1e-14 52.1 1.2 4.3e-09 36.1 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX54135.1 - 0.00029 20.3 4.6 0.0033 16.8 0.2 2.6 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region zf-CHC2 PF01807.20 ORX54135.1 - 0.0029 17.4 0.0 0.03 14.1 0.0 2.3 2 0 0 2 2 2 1 CHC2 zinc finger AAA_29 PF13555.6 ORX54135.1 - 0.025 14.3 0.0 0.057 13.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 ORX54135.1 - 0.04 14.1 0.2 1.6 9.0 0.1 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 ORX54135.1 - 0.045 12.8 0.0 0.094 11.8 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain AAA_15 PF13175.6 ORX54135.1 - 0.067 12.9 0.2 2.3 7.9 0.1 2.0 1 1 1 2 2 2 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ORX54135.1 - 0.1 12.0 0.0 0.25 10.7 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Rap_GAP PF02145.15 ORX54136.1 - 1.3e-52 178.1 0.0 1.7e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Rap/ran-GAP Ribonucleas_3_3 PF14622.6 ORX54137.1 - 1.5e-14 54.2 0.0 2.1e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ORX54137.1 - 2.3e-08 34.6 0.0 6.7e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 Ribonuclease III domain dsrm PF00035.26 ORX54137.1 - 2.8e-05 24.7 0.0 4.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF5464 PF17552.2 ORX54137.1 - 0.39 11.0 3.9 7.5 6.9 0.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5464) MIR PF02815.19 ORX54138.1 - 2.4e-13 50.4 0.2 1.7e-12 47.6 0.2 2.0 1 1 0 1 1 1 1 MIR domain JmjC PF02373.22 ORX54139.1 - 2.2e-45 153.7 2.5 3.5e-45 153.1 1.0 2.1 2 0 0 2 2 2 1 JmjC domain, hydroxylase zf-HC5HC2H PF13771.6 ORX54139.1 - 1.4e-19 70.2 5.5 3.6e-19 68.8 5.5 1.8 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX54139.1 - 9.1e-17 61.2 10.1 1.9e-16 60.2 10.1 1.6 1 0 0 1 1 1 1 PHD-zinc-finger like domain JmjN PF02375.17 ORX54139.1 - 1.9e-08 34.1 0.3 3.4e-08 33.3 0.3 1.4 1 0 0 1 1 1 1 jmjN domain DUF1325 PF07039.11 ORX54139.1 - 0.036 14.1 0.0 0.071 13.2 0.0 1.4 1 0 0 1 1 1 0 SGF29 tudor-like domain LBR_tudor PF09465.10 ORX54139.1 - 0.078 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Lamin-B receptor of TUDOR domain CDC50 PF03381.15 ORX54140.1 - 8e-69 232.2 0.1 9.7e-69 232.0 0.1 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DuoxA PF10204.9 ORX54140.1 - 0.11 11.4 0.1 0.21 10.6 0.1 1.3 1 0 0 1 1 1 0 Dual oxidase maturation factor bZIP_1 PF00170.21 ORX54141.1 - 3.7e-12 46.2 8.5 7e-12 45.3 8.3 1.5 1 1 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX54141.1 - 5.5e-07 29.6 8.7 5.5e-07 29.6 8.7 2.2 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX54141.1 - 0.0041 17.6 5.5 0.0097 16.4 5.5 1.6 1 0 0 1 1 1 1 bZIP Maf transcription factor HMMR_C PF15908.5 ORX54141.1 - 0.016 15.5 1.6 0.027 14.7 0.8 1.7 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal UPF0242 PF06785.11 ORX54141.1 - 0.028 14.5 1.9 0.051 13.7 1.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2353 PF09789.9 ORX54141.1 - 0.03 13.7 4.8 0.051 12.9 4.8 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) YabA PF06156.13 ORX54141.1 - 0.1 13.3 0.7 0.26 11.9 0.7 1.7 1 0 0 1 1 1 0 Initiation control protein YabA GIT_CC PF16559.5 ORX54141.1 - 0.11 12.4 0.2 0.26 11.2 0.2 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor KASH_CCD PF14662.6 ORX54141.1 - 0.16 11.7 3.4 0.27 11.0 3.4 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH TMF_TATA_bd PF12325.8 ORX54141.1 - 0.19 11.9 1.4 0.42 10.9 1.4 1.6 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding ATG27 PF09451.10 ORX54142.1 - 6.9e-42 144.1 0.0 8.1e-42 143.9 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 ORX54142.1 - 0.002 17.3 0.2 0.0034 16.5 0.0 1.4 2 0 0 2 2 2 1 Mannose-6-phosphate receptor MtrB_PioB PF11854.8 ORX54142.1 - 0.034 12.5 0.0 0.044 12.1 0.0 1.1 1 0 0 1 1 1 0 Putative outer membrane beta-barrel porin, MtrB/PioB Homeobox_KN PF05920.11 ORX54143.1 - 1.4e-18 66.5 0.5 3.2e-18 65.3 0.5 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX54143.1 - 8.7e-08 31.9 0.7 2.2e-07 30.6 0.7 1.7 1 0 0 1 1 1 1 Homeodomain Integrin_b_cyt PF08725.11 ORX54143.1 - 0.053 13.2 0.5 0.11 12.2 0.5 1.5 1 0 0 1 1 1 0 Integrin beta cytoplasmic domain RhoGAP PF00620.27 ORX54144.1 - 0.0023 17.8 0.3 0.026 14.4 0.1 2.5 2 1 1 3 3 3 2 RhoGAP domain ubiquitin PF00240.23 ORX54145.1 - 1.2e-101 332.5 14.4 2.1e-33 113.9 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ORX54145.1 - 3.1e-46 155.1 14.8 6.1e-15 54.8 0.8 3.0 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX54145.1 - 4.1e-17 62.4 6.5 0.00041 20.7 0.2 4.6 3 3 0 3 3 3 3 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ORX54145.1 - 2.4e-11 43.9 5.5 0.019 15.3 0.1 3.1 3 0 0 3 3 3 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX54145.1 - 3.4e-11 43.2 1.3 0.066 13.3 0.0 3.9 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ORX54145.1 - 7.9e-11 41.7 2.5 0.049 13.6 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ORX54145.1 - 9.2e-10 39.0 0.6 0.13 12.9 0.2 3.2 1 1 2 3 3 3 3 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 ORX54145.1 - 2e-07 31.0 0.2 0.69 9.7 0.0 3.1 1 1 2 3 3 3 3 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 ORX54145.1 - 9.2e-06 25.7 1.6 3.4 7.9 0.0 3.2 3 0 0 3 3 3 3 Domain of Unknown Function with PDB structure (DUF3861) Ubiquitin_4 PF18036.1 ORX54145.1 - 3.8e-05 23.7 16.6 17 5.6 0.0 6.0 6 0 0 6 6 6 0 Ubiquitin-like domain ACT_5 PF13710.6 ORX54145.1 - 0.00018 21.3 2.9 6.1 6.8 0.1 3.3 3 0 0 3 3 3 0 ACT domain DUF2870 PF11069.8 ORX54145.1 - 0.0003 21.1 0.0 20 5.6 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2870) Big_7 PF17957.1 ORX54145.1 - 0.00037 21.2 0.1 23 5.8 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig domain Methyltrans_RNA PF04452.14 ORX54145.1 - 0.001 18.5 0.1 1.5 8.1 0.0 2.4 2 0 0 2 2 2 2 RNA methyltransferase DUF493 PF04359.14 ORX54145.1 - 0.0013 19.3 0.0 32 5.2 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Raf1_HTH PF18579.1 ORX54145.1 - 0.0022 17.7 0.5 26 4.6 0.0 3.3 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain Big_3_3 PF13750.6 ORX54145.1 - 0.0024 17.6 0.0 22 4.7 0.0 3.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) DUF1940 PF09155.10 ORX54145.1 - 0.0034 17.5 2.2 20 5.3 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1940) DUF969 PF06149.12 ORX54145.1 - 0.008 15.6 0.0 15 5.0 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) ACT_4 PF13291.6 ORX54145.1 - 0.0093 16.5 0.5 59 4.3 0.0 3.3 3 0 0 3 3 3 0 ACT domain UDP-g_GGTase PF06427.11 ORX54145.1 - 0.011 15.9 3.9 4.1 7.6 0.1 3.2 4 0 0 4 4 3 0 UDP-glucose:Glycoprotein Glucosyltransferase ORF11CD3 PF10549.9 ORX54145.1 - 0.063 13.4 0.0 62 3.8 0.0 3.6 3 0 0 3 3 3 0 ORF11CD3 domain ProRS-C_2 PF09181.10 ORX54145.1 - 0.07 13.3 3.0 55 4.0 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal Baculo_p48 PF04878.13 ORX54145.1 - 0.088 11.7 0.1 13 4.6 0.0 2.4 3 0 0 3 3 3 0 Baculovirus P48 protein Tash_PEST PF07708.11 ORX54145.1 - 0.13 12.5 18.4 4.5 7.6 1.4 3.3 3 0 0 3 3 3 0 Tash protein PEST motif FidL_like PF15941.5 ORX54145.1 - 0.13 12.7 2.5 79 3.8 0.1 3.5 3 0 0 3 3 3 0 FidL-like putative membrane protein Myosin_N PF02736.19 ORX54145.1 - 0.22 11.4 2.6 76 3.3 0.0 4.0 3 0 0 3 3 3 0 Myosin N-terminal SH3-like domain DMA PF03474.14 ORX54145.1 - 0.44 10.2 1.7 1.1e+02 2.5 0.0 3.2 3 0 0 3 3 3 0 DMRTA motif PI3K_p85B PF02192.16 ORX54145.1 - 0.97 9.2 5.2 67 3.3 0.1 3.3 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain FlgD_ig PF13860.6 ORX54145.1 - 1 9.3 4.6 91 3.0 0.1 3.3 3 0 0 3 3 3 0 FlgD Ig-like domain DEAD PF00270.29 ORX54146.1 - 7.3e-33 113.8 0.0 1.5e-32 112.8 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX54146.1 - 3.3e-28 98.3 0.0 8.2e-28 97.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 ORX54146.1 - 0.082 12.6 0.0 0.25 11.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain HAD_2 PF13419.6 ORX54147.1 - 3.2e-13 50.2 0.0 4.3e-13 49.7 0.0 1.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX54147.1 - 1.1e-08 35.7 0.0 1.4e-08 35.3 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX54147.1 - 0.00018 21.5 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ORX54147.1 - 0.033 14.6 0.0 0.045 14.1 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase FSA_C PF10479.9 ORX54148.1 - 0.71 7.9 7.6 1 7.4 7.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Peptidase_S10 PF00450.22 ORX54150.1 - 1.4e-106 357.4 7.0 1.8e-106 357.1 7.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase HTH_28 PF13518.6 ORX54152.1 - 1.1e-06 28.6 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_32 PF13565.6 ORX54152.1 - 7.5e-06 26.5 0.0 1.3e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain HTH_23 PF13384.6 ORX54152.1 - 0.00056 19.6 0.1 0.0011 18.8 0.1 1.4 1 0 0 1 1 1 1 Homeodomain-like domain DUF1804 PF08822.11 ORX54152.1 - 0.002 18.1 0.2 0.0032 17.5 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1804) HTH_Tnp_4 PF13613.6 ORX54152.1 - 0.016 14.9 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix of DDE superfamily endonuclease BrkDBD PF09607.10 ORX54152.1 - 0.02 14.6 0.4 0.037 13.8 0.4 1.4 1 0 0 1 1 1 0 Brinker DNA-binding domain CENP-B_N PF04218.13 ORX54152.1 - 0.03 14.0 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_29 PF13551.6 ORX54152.1 - 0.071 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix RRM_9 PF18444.1 ORX54154.1 - 0.021 14.7 0.1 0.49 10.3 0.1 2.9 2 1 0 2 2 2 0 RNA recognition motif RA PF00788.23 ORX54156.1 - 2.3e-10 41.0 0.0 6.8e-07 29.8 0.0 3.2 2 1 1 3 3 3 2 Ras association (RalGDS/AF-6) domain CK2S PF15011.6 ORX54356.1 - 0.024 14.5 0.3 2 8.3 0.0 2.5 2 0 0 2 2 2 0 Casein Kinase 2 substrate PS_Dcarbxylase PF02666.15 ORX54358.1 - 1.1e-54 185.0 0.0 1.6e-54 184.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase BBS2_Mid PF14783.6 ORX54358.1 - 0.0076 16.3 0.0 0.019 15.0 0.0 1.6 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region Ofd1_CTDD PF10637.9 ORX54361.1 - 1.5e-76 257.2 0.0 3e-73 246.3 0.0 2.8 2 1 1 3 3 3 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 ORX54361.1 - 1.5e-32 112.1 0.0 2.9e-32 111.2 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ORX54361.1 - 1.9e-16 60.7 0.0 5.9e-16 59.1 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Arc_PepC PF06819.11 ORX54361.1 - 0.27 11.4 0.6 32 4.7 0.2 2.4 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminal Domain Gtr1_RagA PF04670.12 ORX54362.1 - 2.9e-69 232.9 0.3 4.2e-69 232.5 0.3 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ORX54362.1 - 2.6e-06 27.0 0.0 4.6e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX54362.1 - 3.4e-06 27.1 0.0 7.7e-06 26.0 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ORX54362.1 - 3e-05 23.9 2.8 0.00026 20.9 0.2 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Ras PF00071.22 ORX54362.1 - 0.00025 20.7 0.0 0.00041 20.0 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX54362.1 - 0.00036 20.7 0.0 0.00086 19.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ORX54362.1 - 0.00058 19.3 0.3 0.0014 18.1 0.0 1.8 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ORX54362.1 - 0.0051 16.4 0.0 0.0086 15.6 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX54362.1 - 0.16 12.3 0.0 1.4 9.3 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain RCC1 PF00415.18 ORX54363.1 - 2.5e-16 60.0 16.4 5.3e-05 23.8 0.1 7.0 7 2 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX54363.1 - 5.9e-12 45.1 21.9 0.0011 18.7 0.2 7.5 7 0 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat PLDc_2 PF13091.6 ORX54364.1 - 1.3e-27 96.3 1.1 4.5e-27 94.6 0.4 2.2 3 0 0 3 3 3 1 PLD-like domain FAM83 PF07894.12 ORX54364.1 - 1e-05 25.3 3.6 0.0011 18.6 3.7 2.4 1 1 0 1 1 1 1 FAM83 A-H PLDc PF00614.22 ORX54364.1 - 0.012 15.7 0.2 0.035 14.3 0.2 1.8 1 0 0 1 1 1 0 Phospholipase D Active site motif DUF2841 PF11001.8 ORX54364.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2841) Cnd1_N PF12922.7 ORX54364.1 - 0.082 12.8 0.1 0.082 12.8 0.1 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term OAD_gamma PF04277.13 ORX54364.1 - 1.5 9.4 10.4 2.8 8.6 0.0 3.3 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain RRM_1 PF00076.22 ORX54365.1 - 1.4e-11 44.0 0.0 2.2e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Romo1 PF10247.9 ORX54366.1 - 2.6e-26 91.8 15.5 3e-26 91.6 15.5 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 DUF3384 PF11864.8 ORX54367.1 - 2.8e-58 198.0 0.6 2.8e-58 198.0 0.6 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3384) Tuberin PF03542.16 ORX54367.1 - 1.3e-45 156.0 0.4 2.6e-41 141.9 0.0 3.7 3 1 0 3 3 3 2 Tuberin Rap_GAP PF02145.15 ORX54367.1 - 1.6e-45 155.0 0.0 2.7e-45 154.2 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Ferrochelatase PF00762.19 ORX54368.1 - 4.5e-112 374.2 0.0 5.2e-112 374.0 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase CbiX PF01903.17 ORX54368.1 - 0.0067 16.7 0.0 3.1 8.2 0.0 3.0 3 0 0 3 3 3 2 CbiX TraE PF05309.11 ORX54368.1 - 0.017 14.5 0.0 0.21 10.9 0.0 2.2 2 0 0 2 2 2 0 TraE protein IBN_N PF03810.19 ORX54369.1 - 2.3e-13 49.9 0.1 6.1e-12 45.3 0.0 3.1 2 0 0 2 2 2 1 Importin-beta N-terminal domain DRIM PF07539.12 ORX54369.1 - 5.6e-09 34.9 2.8 0.0081 14.5 0.1 4.1 4 1 1 5 5 5 3 Down-regulated in metastasis Cse1 PF08506.10 ORX54369.1 - 1.2e-05 24.4 5.1 0.00024 20.1 4.4 2.8 2 1 0 2 2 2 1 Cse1 Xpo1 PF08389.12 ORX54369.1 - 0.0056 16.8 7.8 0.45 10.6 0.0 5.6 7 0 0 7 7 7 1 Exportin 1-like protein HEAT PF02985.22 ORX54369.1 - 0.044 14.1 0.4 33 5.1 0.0 5.0 5 1 1 6 6 6 0 HEAT repeat CARD PF00619.21 ORX54369.1 - 0.13 12.3 0.1 2.1 8.4 0.0 2.9 3 0 0 3 3 3 0 Caspase recruitment domain Kinesin PF00225.23 ORX54370.1 - 2.4e-88 296.3 0.0 3.8e-88 295.6 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX54370.1 - 5.7e-15 55.6 0.0 1.7e-14 54.0 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DUF3071 PF11268.8 ORX54370.1 - 0.045 13.8 0.0 0.098 12.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) GTA_holin_3TM PF11351.8 ORX54370.1 - 0.13 12.8 0.0 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Com_YlbF PF06133.11 ORX54370.1 - 3.6 8.2 10.0 3.8 8.1 2.9 2.4 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA VRR_NUC PF08774.11 ORX54373.1 - 1.5e-24 86.1 0.0 4.5e-24 84.6 0.0 1.8 1 0 0 1 1 1 1 VRR-NUC domain DUF5102 PF17104.5 ORX54374.1 - 1.5e-30 107.2 13.3 1.5e-30 107.2 13.3 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF5102) Ras PF00071.22 ORX54375.1 - 1.7e-58 196.8 0.0 2e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX54375.1 - 2.8e-33 114.7 0.0 4.2e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX54375.1 - 2.7e-12 46.5 0.0 3e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX54375.1 - 2.9e-07 30.6 0.0 6e-07 29.6 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ORX54375.1 - 1.5e-05 24.4 0.0 1.9e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX54375.1 - 4.8e-05 23.0 0.0 0.0014 18.2 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX54375.1 - 0.00029 20.8 0.2 0.0026 17.7 0.2 2.2 1 1 2 3 3 3 1 RsgA GTPase PduV-EutP PF10662.9 ORX54375.1 - 0.0037 17.0 0.1 0.35 10.6 0.1 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ORX54375.1 - 0.0042 16.7 0.0 0.0094 15.6 0.0 1.5 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ATP_bind_1 PF03029.17 ORX54375.1 - 0.0063 16.3 0.3 0.14 11.9 0.0 2.0 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ORX54375.1 - 0.0078 16.5 0.0 0.017 15.4 0.0 1.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX54375.1 - 0.01 16.2 0.0 0.017 15.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ORX54375.1 - 0.012 15.4 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX54375.1 - 0.032 13.7 0.1 0.054 13.0 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase_2 PF01637.18 ORX54375.1 - 0.039 13.9 0.1 0.067 13.1 0.1 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_5 PF07728.14 ORX54375.1 - 0.043 13.8 0.0 0.092 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Septin PF00735.18 ORX54375.1 - 0.053 12.8 0.1 0.11 11.7 0.1 1.6 2 0 0 2 2 2 0 Septin NTPase_1 PF03266.15 ORX54375.1 - 0.059 13.3 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 ORX54375.1 - 0.062 12.5 0.1 0.095 11.9 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ORX54375.1 - 0.082 12.8 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 NACHT domain SRPRB PF09439.10 ORX54375.1 - 0.085 12.3 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 ORX54375.1 - 0.1 12.0 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ORX54375.1 - 0.13 12.7 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DAP3 PF10236.9 ORX54375.1 - 0.2 10.8 0.2 0.31 10.1 0.2 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 KH_1 PF00013.29 ORX54376.1 - 6.3e-29 99.6 0.4 3.5e-08 33.2 0.0 7.6 7 1 0 7 7 7 6 KH domain KH_2 PF07650.17 ORX54376.1 - 1.9 8.4 3.2 3.3 7.6 0.2 2.4 1 1 1 2 2 2 0 KH domain ArsA_ATPase PF02374.15 ORX54377.1 - 1.2e-106 356.3 0.2 2e-106 355.7 0.2 1.3 1 0 0 1 1 1 1 Anion-transporting ATPase DnaJ_C PF01556.18 ORX54377.1 - 3.4e-44 150.5 0.2 6.5e-44 149.6 0.2 1.5 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ORX54377.1 - 8.3e-17 61.3 17.6 8.3e-17 61.3 17.6 2.1 2 0 0 2 2 2 1 DnaJ central domain AAA_31 PF13614.6 ORX54377.1 - 8.4e-13 48.6 0.0 2.6e-12 47.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ORX54377.1 - 4.2e-11 43.0 0.0 1.2e-10 41.5 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DnaJ PF00226.31 ORX54377.1 - 4.6e-08 33.1 0.2 1.2e-07 31.8 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain CBP_BcsQ PF06564.12 ORX54377.1 - 1.1e-05 25.1 0.0 1.9e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ ParA PF10609.9 ORX54377.1 - 7.3e-05 22.3 0.1 0.00041 19.9 0.0 2.1 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 ORX54377.1 - 0.00012 21.6 0.0 0.00027 20.5 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 ORX54377.1 - 0.00037 20.2 0.1 0.0027 17.4 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 ORX54377.1 - 0.0071 15.9 0.0 0.029 14.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain Cytochrome_CBB3 PF13442.6 ORX54377.1 - 0.011 16.1 0.5 1.6 9.1 0.1 3.3 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III NB-ARC PF00931.22 ORX54377.1 - 0.062 12.5 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain PDZ_6 PF17820.1 ORX54377.1 - 0.18 11.7 0.1 0.43 10.5 0.1 1.6 1 0 0 1 1 1 0 PDZ domain Zeta_toxin PF06414.12 ORX54377.1 - 0.18 11.0 0.0 0.36 10.1 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Anti-TRAP PF15777.5 ORX54377.1 - 0.81 9.7 14.0 0.42 10.6 2.0 2.6 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Cytochrom_c3_2 PF14537.6 ORX54377.1 - 4 8.0 15.4 52 4.4 2.6 3.2 2 1 1 3 3 3 0 Cytochrome c3 FAD_binding_6 PF00970.24 ORX54381.1 - 1.1e-33 115.5 0.0 1.7e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ORX54381.1 - 2.9e-32 111.5 0.0 4.2e-32 111.0 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ORX54381.1 - 2.1e-08 34.5 0.0 6e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain Rhomboid PF01694.22 ORX54382.1 - 5.3e-19 68.7 1.0 8.1e-19 68.1 1.0 1.3 1 0 0 1 1 1 1 Rhomboid family DUF3292 PF11696.8 ORX54383.1 - 0.22 9.9 13.0 0.23 9.8 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3435 PF11917.8 ORX54383.1 - 1.3 7.9 11.2 1.3 7.9 11.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) p450 PF00067.22 ORX54383.1 - 2.2 6.9 8.4 2.2 6.9 8.4 1.0 1 0 0 1 1 1 0 Cytochrome P450 AA_permease PF00324.21 ORX54384.1 - 8.9e-133 443.4 34.2 1.1e-132 443.0 34.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX54384.1 - 3.2e-40 138.3 37.4 3.9e-40 138.0 37.4 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4173 PF13777.6 ORX54384.1 - 0.037 13.4 0.2 0.037 13.4 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4173) FtsX PF02687.21 ORX54384.1 - 0.062 13.8 0.4 0.062 13.8 0.4 4.7 3 1 2 5 5 5 0 FtsX-like permease family YEATS PF03366.16 ORX54385.1 - 7.9e-36 121.9 0.7 1.1e-35 121.4 0.7 1.2 1 0 0 1 1 1 1 YEATS family DASH_Dad1 PF08649.10 ORX54386.1 - 9.4e-17 61.0 0.2 1.3e-16 60.5 0.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 ORX54386.1 - 6.1e-05 22.9 0.1 7.7e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad4 Cnd1_N PF12922.7 ORX54386.1 - 0.067 13.0 0.0 0.074 12.9 0.0 1.0 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term NPV_P10 PF05531.12 ORX54386.1 - 0.088 13.3 0.2 0.11 12.9 0.2 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein AtuA PF07287.11 ORX54387.1 - 2.1e-109 365.5 0.0 2.5e-109 365.2 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA Na_sulph_symp PF00939.19 ORX54388.1 - 3.5e-27 95.6 41.8 9e-16 58.0 14.0 3.3 1 1 2 3 3 3 3 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX54388.1 - 2.9e-23 82.5 44.5 3.5e-14 52.7 25.1 2.4 1 1 1 2 2 2 2 Citrate transporter RicinB_lectin_2 PF14200.6 ORX54389.1 - 0.021 15.5 4.1 0.13 13.0 0.0 2.7 1 1 2 3 3 3 0 Ricin-type beta-trefoil lectin domain-like MAPKK1_Int PF08923.10 ORX54390.1 - 4e-26 91.2 0.0 4.9e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting PCI PF01399.27 ORX54391.1 - 5.8e-09 36.4 0.4 1.2e-08 35.4 0.1 1.7 2 0 0 2 2 2 1 PCI domain Methyltransf_23 PF13489.6 ORX54392.1 - 3.2e-16 59.6 0.1 5.9e-16 58.7 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX54392.1 - 3.8e-12 46.8 0.0 1.8e-11 44.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX54392.1 - 7.3e-12 45.8 0.0 1.6e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX54392.1 - 6.5e-10 39.0 0.0 4.5e-09 36.3 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX54392.1 - 6.8e-05 22.3 0.0 0.00034 20.0 0.0 2.0 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ORX54392.1 - 6.9e-05 22.4 0.0 0.0087 15.5 0.0 2.6 3 0 0 3 3 3 1 Putative methyltransferase Methyltransf_2 PF00891.18 ORX54392.1 - 0.00046 19.5 0.0 0.00099 18.5 0.0 1.6 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 ORX54392.1 - 0.00085 18.7 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ORX54392.1 - 0.0009 18.8 0.0 0.0067 16.0 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ORX54392.1 - 0.0014 18.5 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.12 ORX54392.1 - 0.0019 18.9 0.0 0.028 15.2 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain CheR PF01739.18 ORX54392.1 - 0.03 13.8 0.0 0.062 12.8 0.0 1.5 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain IMPDH PF00478.25 ORX54393.1 - 1.3e-130 435.4 5.3 1.6e-130 435.2 5.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ORX54393.1 - 5.6e-13 49.1 0.1 6.6e-06 26.5 0.0 2.5 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 ORX54393.1 - 8.9e-09 34.8 1.0 1.7e-08 33.9 1.0 1.4 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 ORX54393.1 - 2.7e-06 27.0 10.9 0.00028 20.4 1.0 3.3 2 1 1 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 ORX54393.1 - 0.00044 19.8 2.7 0.0041 16.6 0.3 2.4 1 1 1 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 ORX54393.1 - 0.00095 18.5 1.8 0.0018 17.6 0.3 2.1 1 1 1 2 2 2 1 Thiazole biosynthesis protein ThiG PK PF00224.21 ORX54393.1 - 0.027 13.4 0.1 0.26 10.2 0.0 2.5 3 1 0 3 3 3 0 Pyruvate kinase, barrel domain Aldolase PF01081.19 ORX54393.1 - 0.037 13.5 0.2 0.037 13.5 0.2 1.8 2 0 0 2 2 2 0 KDPG and KHG aldolase Dpy19 PF10034.9 ORX54393.1 - 0.22 9.6 0.0 0.32 9.1 0.0 1.1 1 0 0 1 1 1 0 Q-cell neuroblast polarisation MLTD_N PF06474.12 ORX54393.1 - 5.7 7.2 7.4 2.6 8.3 3.0 2.4 2 0 0 2 2 2 0 MltD lipid attachment motif PhoLip_ATPase_C PF16212.5 ORX54394.1 - 2.9e-74 250.0 29.3 2.9e-74 250.0 29.3 2.4 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX54394.1 - 1.5e-23 82.2 2.3 1.5e-23 82.2 2.3 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX54394.1 - 3.8e-14 52.6 0.0 2.7e-13 49.8 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX54394.1 - 2.5e-07 31.2 2.5 0.00022 21.6 0.5 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX54394.1 - 1e-05 25.1 0.0 1e-05 25.1 0.0 3.3 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX54394.1 - 0.0036 17.1 0.2 0.013 15.3 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ALIX_LYPXL_bnd PF13949.6 ORX54394.1 - 0.76 9.0 3.6 9.5 5.4 0.1 2.3 2 0 0 2 2 2 0 ALIX V-shaped domain binding to HIV DUF2207 PF09972.9 ORX54394.1 - 4.4 5.9 11.0 6.1 5.5 0.0 3.4 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF3128 PF11326.8 ORX54395.1 - 3.9e-24 84.8 5.6 4.9e-24 84.5 5.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) R2K_2 PF18299.1 ORX54395.1 - 0.057 13.3 0.3 0.062 13.2 0.3 1.2 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 Ndufs5 PF10200.9 ORX54395.1 - 0.058 13.7 1.3 0.091 13.0 1.3 1.4 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa DENN PF02141.21 ORX54396.1 - 1.2e-44 152.5 0.7 2.6e-44 151.4 0.7 1.6 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 ORX54396.1 - 9.6e-13 47.9 4.2 3.5e-12 46.1 4.2 2.1 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 ORX54396.1 - 1.9e-12 47.7 2.0 6.7e-12 46.0 1.4 2.4 2 0 0 2 2 2 1 uDENN domain GATase PF00117.28 ORX54397.1 - 3.7e-11 43.1 0.1 1.5e-06 28.2 0.0 2.1 1 1 1 2 2 2 2 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX54397.1 - 0.00037 20.3 1.1 0.12 12.2 0.1 2.7 2 1 1 3 3 3 2 Peptidase C26 HTS PF04204.16 ORX54397.1 - 0.0041 16.1 0.0 0.41 9.5 0.0 2.1 1 1 1 2 2 2 2 Homoserine O-succinyltransferase Pox_J1 PF03338.15 ORX54397.1 - 0.0042 16.9 0.1 0.17 11.7 0.0 2.2 2 0 0 2 2 2 1 Poxvirus J1 protein SNO PF01174.19 ORX54397.1 - 0.085 12.7 0.0 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 SNO glutamine amidotransferase family DUF5572 PF17733.1 ORX54398.1 - 3e-21 75.0 0.6 4.9e-21 74.3 0.6 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Myb_DNA-binding PF00249.31 ORX54399.1 - 0.00023 21.3 0.1 0.0012 19.0 0.0 2.1 1 1 1 2 2 2 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX54399.1 - 0.003 17.8 0.4 0.0059 16.8 0.4 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-RRN7 PF11781.8 ORX54400.1 - 0.00069 19.2 2.0 0.0014 18.3 2.0 1.5 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Tfb5 PF06331.12 ORX54401.1 - 1.7e-15 56.7 0.8 1.9e-15 56.6 0.8 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 GSHPx PF00255.19 ORX54402.1 - 1e-42 144.1 1.2 1.3e-42 143.8 1.2 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ORX54402.1 - 4.9e-09 36.2 0.2 2.6e-08 33.8 0.2 1.9 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX54402.1 - 6.7e-06 25.9 0.3 4e-05 23.4 0.3 2.0 1 1 0 1 1 1 1 Redoxin YtfJ_HI0045 PF09695.10 ORX54402.1 - 0.019 14.6 0.1 0.052 13.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (YtfJ_HI0045) RNB PF00773.19 ORX54403.1 - 9.7e-80 268.3 0.0 1.8e-79 267.4 0.0 1.5 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX54403.1 - 1.9e-20 72.7 0.0 4.3e-20 71.5 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ORX54403.1 - 1e-13 51.4 0.0 3.6e-13 49.7 0.0 2.0 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal MCM PF00493.23 ORX54404.1 - 6.9e-103 342.6 0.5 1.1e-102 341.9 0.5 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX54404.1 - 4.8e-39 133.1 0.3 1.4e-38 131.6 0.3 1.8 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 ORX54404.1 - 8.4e-27 93.5 9.7 8.4e-27 93.5 9.7 1.9 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 ORX54404.1 - 9.3e-25 86.9 1.5 2.2e-24 85.7 1.5 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX54404.1 - 9.7e-21 74.3 0.6 3.3e-20 72.6 0.6 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX54404.1 - 1.4e-07 31.1 0.0 5.5e-07 29.2 0.0 1.9 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX54404.1 - 0.0001 22.2 0.0 0.00033 20.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX54404.1 - 0.0018 18.3 0.0 0.004 17.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 ORX54404.1 - 0.0023 17.7 0.0 0.0052 16.5 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain EAR PF07897.11 ORX54405.1 - 2.1 8.0 4.3 19 5.0 0.2 2.5 2 0 0 2 2 2 0 Ethylene-responsive binding factor-associated repression OrfB_Zn_ribbon PF07282.11 ORX54406.1 - 0.00025 20.9 0.1 0.00043 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain MIF4G PF02854.19 ORX54407.1 - 1e-44 152.7 2.3 5.4e-44 150.4 0.0 2.4 3 0 0 3 3 3 1 MIF4G domain MA3 PF02847.17 ORX54407.1 - 1e-12 48.0 1.2 2.5e-12 46.8 1.2 1.7 1 0 0 1 1 1 1 MA3 domain DUF3385 PF11865.8 ORX54407.1 - 0.1 12.5 0.3 0.22 11.4 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) Acyltransferase PF01553.21 ORX54408.1 - 2.9e-22 78.7 0.0 4.7e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ORX54408.1 - 4.3e-16 58.8 0.2 7.6e-16 58.0 0.2 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus TP_methylase PF00590.20 ORX54409.1 - 3.9e-47 160.9 0.1 2.4e-46 158.4 0.0 2.2 3 0 0 3 3 3 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_C PF14823.6 ORX54409.1 - 1.8e-20 72.3 1.0 3.7e-20 71.3 1.0 1.5 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal NAD_binding_7 PF13241.6 ORX54409.1 - 5.8e-15 55.6 0.0 1.6e-14 54.2 0.0 1.8 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 ORX54409.1 - 4.6e-10 38.8 0.3 1.1e-09 37.5 0.3 1.7 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central UCH PF00443.29 ORX54410.1 - 1.8e-44 152.2 0.0 5.4e-44 150.6 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 ORX54410.1 - 5.1e-19 68.0 0.0 5.7e-10 39.0 0.0 3.0 2 0 0 2 2 2 2 A repeated domain in UCH-protein UCH_1 PF13423.6 ORX54410.1 - 0.0012 18.6 17.0 0.13 11.8 17.0 2.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PUB PF09409.10 ORX54410.1 - 0.051 13.5 0.0 0.13 12.2 0.0 1.7 1 0 0 1 1 1 0 PUB domain Fib_alpha PF08702.10 ORX54410.1 - 2.9 8.1 6.5 0.71 10.0 2.0 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family BAF250_C PF12031.8 ORX54411.1 - 9.1e-07 28.4 0.0 3e-06 26.7 0.0 1.9 2 0 0 2 2 2 1 SWI/SNF-like complex subunit BAF250/Osa Sec7 PF01369.20 ORX54416.1 - 4.5e-32 111.2 0.3 1.1e-31 109.9 0.1 1.9 2 1 0 2 2 2 1 Sec7 domain PH_9 PF15410.6 ORX54416.1 - 1.5e-31 109.3 0.1 3.9e-31 107.9 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX54416.1 - 0.00099 19.6 0.0 0.0034 17.9 0.0 1.9 1 0 0 1 1 1 1 PH domain NPL4 PF05021.15 ORX54417.1 - 1.9e-110 369.1 0.0 2.7e-110 368.5 0.0 1.2 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 ORX54417.1 - 1.7e-63 213.1 0.4 3.1e-63 212.2 0.4 1.5 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 ORX54417.1 - 9.3e-13 48.5 0.0 2.1e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 DUF3320 PF11784.8 ORX54417.1 - 0.033 14.2 0.0 0.09 12.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3320) USP7_ICP0_bdg PF12436.8 ORX54417.1 - 0.056 12.8 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 TMEM18 PF14770.6 ORX54417.1 - 0.21 11.6 0.0 0.35 10.9 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 18 LRR_6 PF13516.6 ORX54418.1 - 2.8e-07 30.0 8.2 0.017 15.2 0.0 4.4 4 0 0 4 4 4 3 Leucine Rich repeat F-box-like PF12937.7 ORX54418.1 - 0.00041 20.2 0.1 0.00097 19.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ORX54418.1 - 0.00084 19.7 2.7 0.0014 18.9 0.1 2.8 4 1 1 5 5 5 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX54418.1 - 0.015 15.8 1.7 46 5.1 0.1 4.1 3 0 0 3 3 3 0 Leucine Rich Repeat CBFD_NFYB_HMF PF00808.23 ORX54419.1 - 1.8e-20 73.0 0.6 3e-20 72.3 0.6 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX54419.1 - 1.9e-16 60.6 0.1 1.9e-16 60.6 0.1 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIIA PF03153.13 ORX54419.1 - 0.014 15.4 20.9 0.021 14.8 20.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-X PF09415.10 ORX54419.1 - 0.044 14.1 0.1 0.087 13.1 0.1 1.6 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF1161 PF06649.12 ORX54419.1 - 0.15 12.3 0.6 5.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1161) UBN_AB PF14075.6 ORX54419.1 - 0.5 10.1 6.2 0.89 9.2 6.2 1.4 1 0 0 1 1 1 0 Ubinuclein conserved middle domain Cpn60_TCP1 PF00118.24 ORX54420.1 - 1.3e-156 522.1 15.3 1.5e-156 521.9 15.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family BRCT PF00533.26 ORX54420.1 - 0.057 13.8 0.6 3.2 8.2 0.3 3.1 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Cpn60_TCP1 PF00118.24 ORX54421.1 - 1.7e-157 525.0 6.2 1.9e-157 524.8 6.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPT PF07931.12 ORX54421.1 - 0.031 14.1 0.1 0.21 11.4 0.2 2.2 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Synapsin_C PF02750.14 ORX54421.1 - 0.16 11.5 0.7 0.33 10.4 0.3 1.6 2 0 0 2 2 2 0 Synapsin, ATP binding domain Acetyltransf_10 PF13673.7 ORX54422.1 - 7.8e-08 32.3 0.1 1.2e-07 31.7 0.1 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX54422.1 - 3.3e-06 27.3 0.1 4.3e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX54422.1 - 0.00011 22.5 0.1 0.00018 21.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX54423.1 - 8.8e-12 45.1 0.1 1.1e-11 44.7 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX54423.1 - 3.1e-10 40.3 0.0 3.9e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX54423.1 - 4.3e-07 30.3 0.0 6.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX54423.1 - 0.00031 20.8 0.1 0.0014 18.7 0.1 1.9 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ORX54423.1 - 0.00066 19.4 0.1 0.00091 19.0 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_4 PF13420.7 ORX54423.1 - 0.0039 17.3 0.0 0.0044 17.2 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX54423.1 - 0.0074 16.4 0.1 0.013 15.6 0.1 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase DUF2156 PF09924.9 ORX54423.1 - 0.026 13.5 0.1 0.031 13.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) RNAse_A_bac PF18431.1 ORX54423.1 - 0.05 14.6 0.0 0.075 14.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial CdiA-CT RNAse A domain Acetyltransf_1 PF00583.25 ORX54424.1 - 8.4e-12 45.4 0.0 1.1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX54424.1 - 5.6e-08 32.8 0.0 7e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX54424.1 - 7.2e-08 32.8 0.0 1.2e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 ORX54424.1 - 0.0031 17.3 0.0 0.0041 16.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain, PanZ FR47 PF08445.10 ORX54424.1 - 0.0041 17.1 0.0 0.01 15.8 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX54424.1 - 0.028 15.1 0.0 0.034 14.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX54424.1 - 0.098 12.8 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 ORX54425.1 - 1.2e-10 41.7 0.0 1.5e-10 41.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX54425.1 - 4.8e-08 33.0 0.0 7.7e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX54425.1 - 1.9e-06 28.2 0.0 3.2e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX54425.1 - 0.00054 19.9 0.0 0.0011 18.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX54425.1 - 0.004 17.8 0.0 0.0055 17.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX54425.1 - 0.019 15.0 0.0 0.042 13.9 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Anp1 PF03452.14 ORX54426.1 - 4.2e-38 131.3 0.0 5.7e-38 130.8 0.0 1.2 1 0 0 1 1 1 1 Anp1 Cyclin_N PF00134.23 ORX54427.1 - 2.4e-09 37.0 0.1 8e-07 28.9 0.1 2.4 2 1 0 2 2 2 2 Cyclin, N-terminal domain Pmp3 PF01679.17 ORX54428.1 - 1.1e-20 73.5 9.4 1.3e-20 73.4 9.4 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RPE65 PF03055.15 ORX54429.1 - 7.8e-84 282.5 0.0 1e-83 282.1 0.0 1.1 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein DUF4187 PF13821.6 ORX54430.1 - 2.9e-22 78.2 1.4 2.9e-22 78.2 1.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) G-patch PF01585.23 ORX54430.1 - 5.3e-14 51.8 6.6 1e-13 50.9 6.6 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX54430.1 - 0.00016 21.6 2.2 0.00049 20.1 2.2 1.9 1 0 0 1 1 1 1 G-patch domain Securin PF04856.13 ORX54430.1 - 0.096 12.7 5.9 0.15 12.0 5.9 1.5 1 1 0 1 1 1 0 Securin sister-chromatid separation inhibitor Citrate_synt PF00285.21 ORX54430.1 - 0.22 10.5 1.4 0.37 9.8 1.4 1.3 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain Hist_deacetyl PF00850.19 ORX54431.1 - 5.1e-82 275.8 0.0 6.9e-82 275.3 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DSPc PF00782.20 ORX54432.1 - 9.2e-30 103.2 0.2 2.2e-29 101.9 0.1 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX54432.1 - 0.0014 18.2 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX54432.1 - 0.026 14.7 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 Inositol hexakisphosphate Yippee-Mis18 PF03226.14 ORX54432.1 - 0.039 14.2 2.0 0.4 10.9 1.5 2.5 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Init_tRNA_PT PF04179.12 ORX54432.1 - 0.07 13.4 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain zinc_ribbon_4 PF13717.6 ORX54432.1 - 0.24 11.3 1.8 14 5.7 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DSPc PF00782.20 ORX54433.1 - 2.4e-27 95.4 0.0 2.7e-27 95.2 0.0 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX54433.1 - 0.0016 18.0 0.0 0.0018 17.9 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ORX54433.1 - 0.038 14.1 0.0 0.045 13.9 0.0 1.1 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ORX54433.1 - 0.061 13.3 0.1 0.069 13.1 0.1 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family AA_permease PF00324.21 ORX54434.1 - 1.6e-123 412.8 42.1 1.9e-123 412.6 42.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX54434.1 - 6.6e-48 163.6 44.1 8.1e-48 163.3 44.1 1.1 1 0 0 1 1 1 1 Amino acid permease MFS_1 PF07690.16 ORX54435.1 - 2.1e-13 49.9 31.0 2.1e-13 49.9 31.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily DEAD PF00270.29 ORX54436.1 - 2.3e-49 167.5 0.0 4.8e-48 163.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX54436.1 - 5.5e-30 104.0 0.0 2.5e-29 101.9 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX54436.1 - 1.9e-05 24.7 0.0 3.9e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Keratin_2_head PF16208.5 ORX54436.1 - 0.013 15.6 12.0 0.013 15.6 12.0 3.5 2 1 1 3 3 3 0 Keratin type II head AAA_30 PF13604.6 ORX54436.1 - 0.014 15.1 0.0 0.34 10.6 0.0 2.9 3 1 0 3 3 3 0 AAA domain UTP25 PF06862.12 ORX54436.1 - 0.074 11.8 0.0 1.5 7.5 0.0 2.1 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Apt1 PF10351.9 ORX54436.1 - 0.31 9.8 8.6 0.45 9.3 8.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Aldo_ket_red PF00248.21 ORX54437.1 - 1.5e-69 234.4 0.0 1.9e-69 234.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family SET PF00856.28 ORX54438.1 - 0.00048 20.5 4.0 0.015 15.7 0.0 3.4 2 2 2 4 4 4 2 SET domain Na_Ca_ex_C PF16494.5 ORX54438.1 - 0.43 11.1 0.0 0.43 11.1 0.0 4.0 4 1 0 4 4 4 0 C-terminal extension of sodium/calcium exchanger domain Zip PF02535.22 ORX54438.1 - 0.63 9.2 28.1 0.012 14.8 20.4 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter BAR_3 PF16746.5 ORX54439.1 - 1.4e-20 74.0 12.1 3.3e-20 72.8 12.1 1.6 1 1 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 ORX54439.1 - 3.5e-13 50.0 0.1 1.1e-12 48.3 0.1 1.9 1 0 0 1 1 1 1 PH domain ArfGap PF01412.18 ORX54439.1 - 5.3e-09 36.2 1.8 4.1e-08 33.3 0.3 2.6 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Inhibitor_I34 PF10466.9 ORX54439.1 - 0.032 14.8 0.7 0.099 13.3 0.7 1.8 1 0 0 1 1 1 0 Saccharopepsin inhibitor I34 PH_11 PF15413.6 ORX54439.1 - 0.076 13.4 1.4 1.4 9.4 1.4 2.7 1 1 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 ORX54439.1 - 3 8.2 4.8 2.4 8.6 0.1 3.1 3 1 0 3 3 3 0 Pleckstrin homology domain Aconitase PF00330.20 ORX54440.1 - 1.4e-154 515.6 0.0 1.7e-154 515.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX54440.1 - 1.3e-40 138.8 0.0 2.3e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain Pkinase PF00069.25 ORX54441.1 - 7.7e-73 245.1 0.0 9.8e-73 244.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54441.1 - 1.1e-33 116.6 0.0 1.5e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54441.1 - 2.9e-08 33.4 0.0 4.8e-07 29.4 0.0 2.0 1 1 0 2 2 2 1 Kinase-like SOG2 PF10428.9 ORX54441.1 - 0.99 8.5 15.1 1.2 8.2 15.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein WW PF00397.26 ORX54442.1 - 3.2e-12 46.3 0.2 5.2e-12 45.6 0.2 1.4 1 0 0 1 1 1 1 WW domain Ssu72 PF04722.13 ORX54444.1 - 7.7e-85 283.3 0.1 8.6e-85 283.1 0.1 1.0 1 0 0 1 1 1 1 Ssu72-like protein PHD PF00628.29 ORX54445.1 - 6.4e-18 64.4 28.9 2.2e-10 40.2 10.7 2.4 2 0 0 2 2 2 2 PHD-finger zf-HC5HC2H PF13771.6 ORX54445.1 - 0.00025 21.2 15.7 0.034 14.4 6.0 2.3 2 0 0 2 2 2 2 PHD-like zinc-binding domain C1_1 PF00130.22 ORX54445.1 - 1.4 8.9 26.3 0.77 9.7 5.5 3.3 3 1 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-PHD-like PF15446.6 ORX54445.1 - 7.7 6.1 15.3 2.4 7.7 0.4 3.3 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain BRCT PF00533.26 ORX54446.1 - 1.6e-07 31.6 0.0 2.7e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX54446.1 - 0.00033 21.0 0.0 0.00058 20.2 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ORX54446.1 - 0.00082 19.3 0.1 0.0015 18.4 0.1 1.4 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 ORX54446.1 - 0.0056 16.9 0.0 0.011 16.0 0.0 1.4 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain bZIP_2 PF07716.15 ORX54447.1 - 3.8e-05 23.7 18.0 7e-05 22.8 12.7 2.4 1 1 1 2 2 2 2 Basic region leucine zipper bZIP_1 PF00170.21 ORX54447.1 - 5.4e-05 23.2 15.1 0.00022 21.3 15.1 1.8 1 1 0 1 1 1 1 bZIP transcription factor YabA PF06156.13 ORX54447.1 - 0.0026 18.4 5.2 0.0026 18.4 5.2 1.5 1 1 1 2 2 2 1 Initiation control protein YabA DUF3450 PF11932.8 ORX54447.1 - 0.15 11.4 6.8 0.16 11.2 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) FOXP-CC PF16159.5 ORX54447.1 - 0.18 12.4 6.2 0.059 14.0 3.4 1.7 2 1 0 2 2 2 0 FOXP coiled-coil domain NRBF2 PF08961.10 ORX54447.1 - 0.25 10.9 7.5 0.3 10.7 7.5 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator bZIP_Maf PF03131.17 ORX54447.1 - 0.3 11.6 12.2 0.51 10.9 12.2 1.3 1 0 0 1 1 1 0 bZIP Maf transcription factor TSC22 PF01166.18 ORX54447.1 - 1.8 9.0 7.6 0.27 11.6 1.4 2.1 1 1 1 2 2 2 0 TSC-22/dip/bun family Pox_G5 PF04599.12 ORX54447.1 - 9.6 5.1 7.6 11 4.9 7.6 1.0 1 0 0 1 1 1 0 Poxvirus G5 protein Mon2_C PF16206.5 ORX54448.1 - 1.6e-78 264.7 10.8 8e-60 202.9 1.5 4.3 3 1 0 3 3 3 3 C-terminal region of Mon2 protein DCB PF16213.5 ORX54448.1 - 6.1e-57 192.1 5.4 1.3e-56 191.0 2.2 3.1 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 ORX54448.1 - 1.6e-53 180.8 3.4 3.1e-52 176.7 2.0 3.5 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 ORX54448.1 - 3.1e-06 26.9 7.4 3.2e-05 23.7 0.0 5.0 5 1 0 5 5 5 1 Domain of unknown function (DUF1981) RWD PF05773.22 ORX54449.1 - 1.9e-23 82.9 2.1 3.6e-23 82.0 2.1 1.5 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 ORX54449.1 - 2.8e-07 30.9 11.3 1.1e-06 29.0 11.3 2.1 1 1 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 PK PF00224.21 ORX54450.1 - 5.1e-151 502.5 2.0 6.2e-151 502.2 2.0 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ORX54450.1 - 7.2e-39 132.7 0.0 2e-38 131.2 0.0 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ORX54450.1 - 0.00073 18.7 0.3 0.0014 17.8 0.1 1.6 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family UPF0128 PF03673.13 ORX54450.1 - 0.064 12.7 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0128) Aminotran_5 PF00266.19 ORX54451.1 - 1.5e-49 168.9 0.0 1.8e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pkinase PF00069.25 ORX54453.1 - 9.9e-59 198.8 0.1 1.7e-58 198.1 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54453.1 - 3.6e-23 82.2 0.0 5.2e-23 81.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54453.1 - 2.9e-06 26.8 0.0 4.3e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX54453.1 - 2e-05 24.1 0.3 3.5e-05 23.3 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PAS PF00989.25 ORX54453.1 - 0.00014 21.8 0.0 1.2 9.2 0.0 3.9 5 0 0 5 5 5 2 PAS fold Haspin_kinase PF12330.8 ORX54453.1 - 0.00047 19.2 0.0 0.0007 18.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX54453.1 - 0.0035 16.2 1.5 0.0054 15.5 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX54453.1 - 0.015 15.3 0.7 0.062 13.2 0.4 2.0 1 1 1 2 2 2 0 Phosphotransferase enzyme family MoCF_biosynth PF00994.24 ORX54454.1 - 1.2e-55 187.1 0.9 1.6e-29 102.4 0.0 2.8 3 0 0 3 3 3 2 Probable molybdopterin binding domain MoeA_N PF03453.17 ORX54454.1 - 1.2e-40 138.9 1.5 2.4e-40 137.8 1.5 1.6 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 ORX54454.1 - 7.6e-16 58.1 0.1 2.4e-15 56.4 0.0 1.9 2 0 0 2 2 2 1 MoeA C-terminal region (domain IV) Inhibitor_I9 PF05922.16 ORX54455.1 - 1.4e-08 35.3 0.2 2.7e-08 34.3 0.2 1.5 1 1 0 1 1 1 1 Peptidase inhibitor I9 Na_Ca_ex PF01699.24 ORX54456.1 - 7.7e-42 142.8 45.9 9e-21 74.4 22.3 2.3 2 0 0 2 2 2 2 Sodium/calcium exchanger protein ESSS PF10183.9 ORX54457.1 - 2.2e-10 40.6 0.0 2.8e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) KAR9 PF08580.10 ORX54459.1 - 1.4e-10 40.4 7.7 1.4e-10 40.4 7.7 3.9 2 2 2 4 4 4 2 Yeast cortical protein KAR9 GAS2 PF02187.17 ORX54459.1 - 7.5e-07 29.1 0.0 3.2e-06 27.1 0.0 2.1 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain BORCS6 PF10157.9 ORX54459.1 - 0.049 13.9 2.0 5.3 7.2 0.1 3.9 2 1 1 3 3 3 0 BLOC-1-related complex sub-unit 6 HMMR_N PF15905.5 ORX54459.1 - 0.89 9.0 5.2 3.4 7.1 5.2 2.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal OrfB_Zn_ribbon PF07282.11 ORX54460.1 - 0.027 14.4 0.4 0.081 12.9 0.4 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain HTH_32 PF13565.6 ORX54462.1 - 3e-06 27.8 0.0 4.4e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ORX54462.1 - 6.9e-05 22.9 0.0 0.0001 22.3 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 ORX54462.1 - 0.00022 21.2 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.6 ORX54462.1 - 0.00047 19.9 0.0 0.00071 19.3 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain Terminase_5 PF06056.12 ORX54462.1 - 0.041 13.8 0.0 0.067 13.1 0.0 1.3 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) CedA PF10729.9 ORX54462.1 - 0.082 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Cell division activator CedA Josephin PF02099.17 ORX54463.1 - 1.8e-45 155.0 0.1 4e-45 153.9 0.1 1.5 1 1 0 1 1 1 1 Josephin BMFP PF04380.13 ORX54465.1 - 0.11 12.9 4.6 1.6 9.2 1.0 2.6 2 1 0 2 2 2 0 Membrane fusogenic activity Laminin_II PF06009.12 ORX54465.1 - 0.84 9.6 5.0 1.3 9.1 1.8 2.3 2 0 0 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 ORX54465.1 - 2.3 8.3 4.4 1.3 9.1 2.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FAM76 PF16046.5 ORX54465.1 - 5.6 6.2 6.0 0.58 9.5 0.2 1.9 2 0 0 2 2 2 0 FAM76 protein TFIIF_beta PF02270.15 ORX54466.1 - 9.6e-26 89.7 0.0 1.5e-25 89.1 0.0 1.3 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain TFIIF_beta_N PF17683.1 ORX54466.1 - 6.8e-13 49.5 10.0 9e-13 49.1 1.8 3.5 2 1 0 3 3 3 1 TFIIF, beta subunit N-terminus DAD PF02109.16 ORX54467.1 - 2.9e-44 149.8 3.7 3.3e-44 149.7 3.7 1.0 1 0 0 1 1 1 1 DAD family HSF_DNA-bind PF00447.17 ORX54468.1 - 6.7e-30 103.6 4.3 3.4e-29 101.3 4.3 2.1 2 0 0 2 2 2 1 HSF-type DNA-binding Response_reg PF00072.24 ORX54468.1 - 3.3e-26 91.7 0.0 5.8e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 Response regulator receiver domain DUF4763 PF15960.5 ORX54468.1 - 0.015 14.6 1.9 0.015 14.6 1.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Viral_protease PF08715.10 ORX54468.1 - 0.038 13.3 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 Papain like viral protease FleQ PF06490.11 ORX54468.1 - 0.044 14.2 0.0 0.1 13.0 0.0 1.6 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ HMGL-like PF00682.19 ORX54470.1 - 1.1e-94 317.0 0.3 1.4e-94 316.6 0.3 1.1 1 0 0 1 1 1 1 HMGL-like Suv3_N PF18114.1 ORX54470.1 - 0.074 13.2 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Suv3 helical N-terminal domain MatE PF01554.18 ORX54471.1 - 6.3e-54 182.0 31.5 1.1e-28 99.9 13.6 2.9 4 0 0 4 4 4 2 MatE Polysacc_synt_C PF14667.6 ORX54471.1 - 0.00014 21.9 10.0 0.00014 21.9 10.0 3.8 2 1 2 4 4 4 2 Polysaccharide biosynthesis C-terminal domain cNMP_binding PF00027.29 ORX54472.1 - 1.9e-40 136.8 0.0 1.5e-21 76.2 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ORX54472.1 - 1.9e-10 40.2 1.7 3.9e-10 39.2 1.7 1.6 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Peptidase_M50 PF02163.22 ORX54473.1 - 1.3e-14 54.0 0.1 1.5e-09 37.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M50 ArsP_1 PF03773.13 ORX54473.1 - 0.042 13.0 4.0 0.8 8.8 0.2 2.3 2 0 0 2 2 2 0 Predicted permease AA_permease_2 PF13520.6 ORX54474.1 - 6.7e-43 147.1 46.6 9.4e-43 146.6 46.6 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX54474.1 - 9.3e-08 31.1 42.1 1.4e-07 30.5 42.1 1.1 1 0 0 1 1 1 1 Amino acid permease CoA_binding_3 PF13727.6 ORX54474.1 - 0.023 14.7 0.5 0.023 14.7 0.5 2.5 2 0 0 2 2 2 0 CoA-binding domain Anoctamin PF04547.12 ORX54474.1 - 4.5 6.0 15.0 1.7e+02 0.8 15.0 2.3 1 1 0 1 1 1 0 Calcium-activated chloride channel DSHCT PF08148.12 ORX54475.1 - 3.3e-52 176.4 0.0 9.1e-52 175.0 0.0 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 ORX54475.1 - 1.2e-32 112.5 0.0 3.3e-32 111.1 0.0 1.8 1 0 0 1 1 1 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 ORX54475.1 - 8.8e-30 104.5 2.1 1.4e-29 103.9 2.1 1.3 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 ORX54475.1 - 2.1e-18 66.7 0.0 4e-18 65.8 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX54475.1 - 1.5e-06 28.5 0.0 1.1e-05 25.7 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX54475.1 - 1.8e-05 24.8 0.0 7.1e-05 22.9 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX54475.1 - 0.068 13.4 0.0 0.25 11.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain Vps39_2 PF10367.9 ORX54476.1 - 3e-09 37.3 0.0 4.7e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Vps39_1 PF10366.9 ORX54477.1 - 2.9e-15 56.5 3.6 7.1e-15 55.2 2.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 CNH PF00780.22 ORX54477.1 - 4.5e-12 46.2 0.0 1.2e-11 44.8 0.0 1.6 2 0 0 2 2 2 1 CNH domain Clathrin PF00637.20 ORX54477.1 - 6.8e-08 32.5 1.4 0.018 14.9 0.0 3.5 3 0 0 3 3 3 3 Region in Clathrin and VPS CM_2 PF01817.21 ORX54478.1 - 0.22 11.9 2.9 3.3 8.1 0.2 2.7 2 1 0 2 2 2 0 Chorismate mutase type II DUF2462 PF09495.10 ORX54481.1 - 8.7e-20 71.2 17.4 8.7e-20 71.2 17.4 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2462) Ribosomal_L27 PF01016.19 ORX54481.1 - 0.014 15.4 1.3 0.016 15.2 1.3 1.1 1 0 0 1 1 1 0 Ribosomal L27 protein RBM39linker PF15519.6 ORX54481.1 - 2.2 9.5 5.7 2.3 9.3 0.1 2.2 1 1 1 2 2 2 0 linker between RRM2 and RRM3 domains in RBM39 protein 2-Hacid_dh_C PF02826.19 ORX54482.1 - 2.4e-54 183.4 0.0 3.7e-54 182.8 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX54482.1 - 1e-27 96.4 0.0 1.2e-27 96.2 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 ORX54482.1 - 0.0031 17.1 0.0 0.22 11.1 0.0 2.4 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AdoHcyase_NAD PF00670.21 ORX54482.1 - 0.006 16.7 0.3 0.11 12.6 0.3 2.4 1 1 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 ORX54482.1 - 0.15 12.5 0.0 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Putative NAD(P)-binding EMC3_TMCO1 PF01956.16 ORX54483.1 - 0.78 9.4 1.5 1 9.1 1.5 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like FancD2 PF14631.6 ORX54484.1 - 1.8e-89 300.7 9.4 7.4e-83 278.9 7.5 2.1 1 1 1 2 2 2 2 Fanconi anaemia protein FancD2 nuclease FANCI_S2 PF14676.6 ORX54484.1 - 0.018 15.4 2.1 0.049 13.9 0.1 2.4 2 0 0 2 2 2 0 FANCI solenoid 2 FancD2 PF14631.6 ORX54485.1 - 7.8e-38 129.7 9.3 5.5e-37 126.9 9.3 1.9 1 1 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease GAF_3 PF13492.6 ORX54485.1 - 0.028 14.8 0.0 4.4 7.7 0.0 2.6 2 0 0 2 2 2 0 GAF domain FancD2 PF14631.6 ORX54486.1 - 8.9e-34 116.2 0.1 1.1e-33 115.9 0.1 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease Scramblase PF03803.15 ORX54486.1 - 0.025 13.9 0.1 0.034 13.5 0.1 1.1 1 0 0 1 1 1 0 Scramblase INO80_Ies4 PF08193.11 ORX54486.1 - 0.95 9.4 11.8 1.1 9.3 4.0 2.2 2 0 0 2 2 2 0 INO80 complex subunit Ies4 HLH PF00010.26 ORX54487.1 - 5e-18 64.8 0.2 5e-18 64.8 0.2 2.7 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain GIT_CC PF16559.5 ORX54487.1 - 0.074 12.9 4.9 1.8 8.5 0.3 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Cyclin_N PF00134.23 ORX54488.1 - 1.2e-11 44.5 0.0 9.2e-09 35.1 0.0 2.3 2 1 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 ORX54488.1 - 0.015 15.7 0.0 0.035 14.5 0.0 1.7 1 0 0 1 1 1 0 Cyclin C-terminal domain Cyclin_C PF02984.19 ORX54488.1 - 0.11 12.5 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Cyclin, C-terminal domain DUF4381 PF14316.6 ORX54489.1 - 0.0012 19.1 0.0 0.0018 18.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Herpes_gE PF02480.16 ORX54489.1 - 0.0018 17.1 0.1 0.0027 16.5 0.1 1.2 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E WBP-1 PF11669.8 ORX54489.1 - 0.016 15.9 0.1 0.078 13.6 0.0 2.1 2 0 0 2 2 2 0 WW domain-binding protein 1 IgaA PF07095.11 ORX54489.1 - 0.018 13.0 0.0 0.026 12.5 0.0 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA O-FucT PF10250.9 ORX54490.1 - 1.4e-14 54.5 1.2 1.2e-11 44.9 1.2 3.0 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase DUF645 PF04875.12 ORX54490.1 - 0.047 13.7 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF645 SMC_ScpB PF04079.16 ORX54490.1 - 0.065 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB HLH PF00010.26 ORX54492.1 - 4.1e-11 42.7 0.6 4.1e-11 42.7 0.6 1.9 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain DivIVA PF05103.13 ORX54492.1 - 6.8 6.8 12.0 1.1 9.3 0.5 2.5 2 1 0 2 2 2 0 DivIVA protein FKBP_C PF00254.28 ORX54494.1 - 3.9e-33 113.7 0.0 4.4e-33 113.5 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FCH PF00611.23 ORX54495.1 - 0.0011 19.2 0.2 0.0011 19.2 0.2 2.9 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain Hexokinase_2 PF03727.16 ORX54496.1 - 4.2e-53 180.2 0.0 6.5e-53 179.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX54496.1 - 1e-49 169.2 0.0 1.5e-49 168.6 0.0 1.3 1 0 0 1 1 1 1 Hexokinase PDEase_I_N PF08499.12 ORX54497.1 - 0.028 14.3 0.1 0.067 13.0 0.1 1.6 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal MFS_1 PF07690.16 ORX54498.1 - 2.1e-42 145.3 49.2 2.5e-41 141.8 48.1 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX54498.1 - 3.7e-12 45.5 22.4 4.9e-12 45.1 22.4 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX54498.1 - 2.1e-07 30.2 15.3 2.1e-07 30.2 15.3 3.1 2 1 0 3 3 3 2 Sugar (and other) transporter End3 PF12761.7 ORX54499.1 - 1.2e-35 123.5 6.4 1.9e-35 122.8 6.4 1.3 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 ORX54499.1 - 1.3e-33 115.1 0.0 8.8e-28 96.3 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ORX54499.1 - 2.5e-08 32.9 1.3 3.9e-06 26.0 0.5 3.3 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 ORX54499.1 - 1.5e-07 31.8 2.6 0.00064 20.1 0.0 3.9 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX54499.1 - 1.5e-05 24.6 2.9 0.016 15.1 0.9 3.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 ORX54499.1 - 0.0084 15.9 0.3 0.034 14.0 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair DUF1720 PF08226.11 ORX54499.1 - 0.02 15.3 24.5 0.06 13.8 24.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1720) Laminin_II PF06009.12 ORX54499.1 - 0.034 14.1 0.8 0.034 14.1 0.8 2.2 2 0 0 2 2 2 0 Laminin Domain II EF-hand_5 PF13202.6 ORX54499.1 - 1.4 8.6 4.1 0.47 10.0 0.4 2.2 2 0 0 2 2 2 0 EF hand DUF2203 PF09969.9 ORX54499.1 - 4.8 7.9 7.3 3.1 8.5 0.7 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DOR PF14839.6 ORX54499.1 - 7 6.5 8.5 11 5.8 8.5 1.2 1 0 0 1 1 1 0 DOR family Fib_alpha PF08702.10 ORX54499.1 - 8.8 6.5 7.5 15 5.8 7.5 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-C2H2 PF00096.26 ORX54500.1 - 3.4e-05 24.1 13.8 0.0043 17.4 5.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX54500.1 - 0.00019 22.0 10.1 0.012 16.4 3.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger Endonuclease_7 PF02945.15 ORX54500.1 - 0.015 15.2 1.9 0.025 14.5 1.9 1.4 1 0 0 1 1 1 0 Recombination endonuclease VII RNA_POL_M_15KD PF02150.16 ORX54500.1 - 0.095 12.6 1.9 0.56 10.1 0.4 2.4 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit zf-C2H2_jaz PF12171.8 ORX54500.1 - 0.096 13.0 1.3 0.096 13.0 1.3 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 ORX54500.1 - 0.16 12.7 5.2 0.6 10.8 5.2 1.9 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats BolA PF01722.18 ORX54500.1 - 0.22 11.8 1.5 0.4 11.0 1.5 1.4 1 0 0 1 1 1 0 BolA-like protein zf-BED PF02892.15 ORX54500.1 - 0.27 11.3 6.1 1 9.5 0.9 2.4 1 1 1 2 2 2 0 BED zinc finger zf-AN1 PF01428.16 ORX54500.1 - 2.9 8.1 6.6 7.1 6.9 2.7 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger zf-H2C2_5 PF13909.6 ORX54500.1 - 8 6.3 12.0 0.15 11.9 1.4 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain PK PF00224.21 ORX54501.1 - 2.7e-164 546.1 3.9 3.3e-164 545.8 3.9 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 ORX54501.1 - 9e-37 125.9 0.0 2.1e-36 124.7 0.0 1.7 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ORX54501.1 - 0.00037 19.7 0.2 0.00091 18.4 0.1 1.7 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 ORX54501.1 - 0.037 13.0 0.2 0.25 10.3 0.0 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain Methyltransf_25 PF13649.6 ORX54502.1 - 1.6e-11 44.7 0.0 7.5e-10 39.4 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX54502.1 - 2e-10 41.2 0.0 9.4e-09 35.8 0.0 3.3 3 1 0 3 3 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX54502.1 - 1.1e-08 35.1 0.0 2.5e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX54502.1 - 6e-06 26.1 0.0 0.024 14.4 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ORX54502.1 - 8.2e-05 23.3 0.0 0.0007 20.3 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX54502.1 - 0.00027 20.3 0.0 0.0064 15.8 0.0 2.1 2 0 0 2 2 2 1 O-methyltransferase domain Ubie_methyltran PF01209.18 ORX54502.1 - 0.00035 20.0 0.0 0.0056 16.1 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ORX54502.1 - 0.0014 18.1 0.0 0.0027 17.2 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_29 PF03141.16 ORX54502.1 - 0.024 13.2 0.0 0.078 11.5 0.0 1.8 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 ORX54502.1 - 0.027 14.0 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 ORX54502.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Abhydrolase_1 PF00561.20 ORX54503.1 - 2e-32 112.9 0.1 3.1e-20 72.9 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX54503.1 - 6.8e-19 69.4 2.1 8.2e-19 69.1 2.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX54503.1 - 9.6e-10 38.1 0.0 3.2e-09 36.4 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 EHN PF06441.12 ORX54503.1 - 6.9e-05 23.2 0.0 0.00023 21.5 0.0 1.9 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_4 PF08386.10 ORX54503.1 - 0.00014 21.9 0.0 0.00028 21.0 0.0 1.4 1 0 0 1 1 1 1 TAP-like protein F-box-like PF12937.7 ORX54505.1 - 0.0007 19.4 4.0 0.046 13.6 0.5 2.8 2 0 0 2 2 2 2 F-box-like HEPN_SAV2148 PF18725.1 ORX54505.1 - 0.11 11.9 0.1 0.21 11.0 0.1 1.4 1 0 0 1 1 1 0 SAV2148-like HEPN Transp_inhibit PF18791.1 ORX54505.1 - 0.4 10.2 2.1 5.2 6.6 0.1 3.5 3 0 0 3 3 3 0 Transport inhibitor response 1 protein domain Amidohydro_1 PF01979.20 ORX54506.1 - 7.1e-64 216.3 0.0 8.6e-64 216.0 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX54506.1 - 8.7e-09 35.4 0.1 5.8e-06 26.0 0.0 2.2 1 1 1 2 2 2 2 Amidohydrolase family Aldo_ket_red PF00248.21 ORX54507.1 - 1.9e-49 168.5 0.0 1.2e-47 162.5 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Exo_endo_phos PF03372.23 ORX54508.1 - 8e-08 32.1 0.0 6e-07 29.2 0.0 2.5 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family BBS2_Mid PF14783.6 ORX54508.1 - 0.0017 18.4 0.0 0.0048 16.9 0.0 1.8 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region UBA_4 PF14555.6 ORX54508.1 - 0.0021 17.8 0.1 0.0046 16.7 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain ANAPC4_WD40 PF12894.7 ORX54508.1 - 0.016 15.5 0.1 1.6 9.0 0.0 3.4 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4729 PF15866.5 ORX54508.1 - 0.1 11.9 0.0 0.31 10.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4729) WD40 PF00400.32 ORX54508.1 - 0.21 12.5 0.1 0.21 12.5 0.1 4.1 4 1 0 4 4 4 0 WD domain, G-beta repeat Aldo_ket_red PF00248.21 ORX54509.1 - 3.5e-71 239.8 0.1 4.1e-71 239.6 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family NT5C PF06941.12 ORX54509.1 - 0.09 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) ENTH PF01417.20 ORX54510.1 - 3.9e-27 94.8 0.0 4.3e-27 94.6 0.0 1.0 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ORX54510.1 - 9.8e-05 21.5 0.0 0.0001 21.4 0.0 1.0 1 0 0 1 1 1 1 ANTH domain PX PF00787.24 ORX54511.1 - 5.4e-09 36.0 0.2 1.1e-08 35.0 0.2 1.6 1 0 0 1 1 1 1 PX domain Ribosomal_L37e PF01907.19 ORX54512.1 - 2.8e-27 94.6 12.0 4.6e-27 93.9 12.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 ORX54512.1 - 0.0075 16.3 1.6 0.011 15.7 1.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 ORX54512.1 - 0.028 14.4 0.9 0.038 14.0 0.9 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_5 PF14634.6 ORX54512.1 - 0.051 13.5 4.0 0.077 13.0 4.0 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX54512.1 - 0.4 10.6 5.0 0.63 9.9 5.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX54512.1 - 0.5 10.3 4.6 0.78 9.7 4.6 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Lipase_3 PF01764.25 ORX54513.1 - 6.1e-16 58.6 0.0 1e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 ORX54513.1 - 0.014 15.2 0.0 0.045 13.5 0.0 1.8 2 0 0 2 2 2 0 Alpha/beta hydrolase family Vta1_C PF18097.1 ORX54513.1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 Vta1 C-terminal domain DUF2974 PF11187.8 ORX54513.1 - 0.14 11.7 0.0 0.32 10.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) AA_permease_2 PF13520.6 ORX54515.1 - 2e-60 204.8 55.4 6.3e-60 203.2 52.3 2.0 1 1 1 2 2 2 2 Amino acid permease AA_permease PF00324.21 ORX54515.1 - 9.6e-28 97.0 44.9 1.3e-27 96.5 44.9 1.1 1 0 0 1 1 1 1 Amino acid permease DASH_Duo1 PF08651.10 ORX54516.1 - 0.11 12.2 0.2 0.18 11.6 0.2 1.2 1 0 0 1 1 1 0 DASH complex subunit Duo1 B12D PF06522.11 ORX54517.1 - 1e-12 47.6 0.2 1.2e-12 47.5 0.2 1.0 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit CLASP_N PF12348.8 ORX54518.1 - 3.3e-23 82.4 5.6 1e-05 25.3 0.0 6.2 6 1 0 6 6 6 4 CLASP N terminal HEAT PF02985.22 ORX54518.1 - 5.3e-12 44.9 13.7 2.3 8.7 0.0 11.4 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 ORX54518.1 - 3.3e-11 43.4 17.9 0.067 13.6 0.1 9.4 9 1 1 10 10 10 3 HEAT repeats HEAT_EZ PF13513.6 ORX54518.1 - 2.5e-07 31.0 16.3 0.0063 17.0 0.1 8.5 7 1 0 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 ORX54518.1 - 1.6e-05 25.0 1.7 1.6 8.8 0.0 6.4 6 3 0 6 6 6 1 non-SMC mitotic condensation complex subunit 1 Ipi1_N PF12333.8 ORX54518.1 - 0.056 14.0 0.0 4.4 7.9 0.0 4.1 4 1 1 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation HTH_3 PF01381.22 ORX54518.1 - 0.094 12.8 0.0 0.6 10.2 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix MMS19_N PF14500.6 ORX54518.1 - 0.23 11.0 4.3 7.6 6.0 0.0 5.0 6 0 0 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II VHS PF00790.19 ORX54518.1 - 0.53 10.1 2.6 9 6.1 0.0 4.1 5 0 0 5 5 5 0 VHS domain GATA PF00320.27 ORX54519.1 - 0.0012 18.5 21.4 0.0015 18.1 8.3 3.2 2 1 1 3 3 3 1 GATA zinc finger DZR PF12773.7 ORX54519.1 - 0.041 13.9 0.5 0.041 13.9 0.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon HypA PF01155.19 ORX54519.1 - 0.15 12.1 4.7 1.5 8.9 0.2 2.2 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ADK_lid PF05191.14 ORX54519.1 - 1.4 9.0 7.6 7.2 6.7 0.1 3.4 3 1 0 3 3 3 0 Adenylate kinase, active site lid SR-25 PF10500.9 ORX54519.1 - 6.1 6.4 6.6 8.3 5.9 6.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3425 PF11905.8 ORX54520.1 - 2.3e-07 30.8 0.2 1.1e-06 28.7 0.2 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) CCDC-167 PF15188.6 ORX54520.1 - 0.14 12.5 4.8 0.31 11.4 4.8 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 bZIP_1 PF00170.21 ORX54520.1 - 0.56 10.3 17.5 0.57 10.3 10.7 2.5 1 1 0 2 2 2 0 bZIP transcription factor DUF3425 PF11905.8 ORX54521.1 - 2.6e-14 53.2 1.2 1e-13 51.3 0.8 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ORX54521.1 - 2.2e-05 24.4 4.9 4.5e-05 23.5 4.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor PspA_IM30 PF04012.12 ORX54521.1 - 0.0081 15.8 1.0 0.015 14.9 1.0 1.3 1 0 0 1 1 1 1 PspA/IM30 family bZIP_Maf PF03131.17 ORX54521.1 - 0.06 13.9 5.7 0.13 12.8 5.7 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor Zwint PF15556.6 ORX54521.1 - 0.11 12.0 1.5 0.21 11.0 1.5 1.4 1 0 0 1 1 1 0 ZW10 interactor MIS13 PF08202.11 ORX54522.1 - 1.7e-11 44.0 0.2 2.8e-11 43.3 0.2 1.3 1 0 0 1 1 1 1 Mis12-Mtw1 protein family PTCB-BRCT PF12738.7 ORX54523.1 - 1.9e-21 75.8 0.1 9.8e-12 44.6 0.1 3.8 5 0 0 5 5 5 2 twin BRCT domain BRCT PF00533.26 ORX54523.1 - 2e-13 50.5 0.0 0.03 14.7 0.0 5.8 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX54523.1 - 6.7e-09 36.0 0.0 0.17 12.3 0.0 5.4 5 0 0 5 5 5 3 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ORX54523.1 - 8.9e-08 31.9 0.1 2.4e-06 27.4 0.0 3.3 5 0 0 5 5 5 1 Regulator of Ty1 transposition protein 107 BRCT domain LIG3_BRCT PF16759.5 ORX54523.1 - 0.0005 20.3 0.0 0.22 11.9 0.0 3.2 4 0 0 4 4 4 1 DNA ligase 3 BRCT domain PB1 PF00564.24 ORX54524.1 - 0.047 13.6 0.0 0.077 12.9 0.0 1.3 1 0 0 1 1 1 0 PB1 domain Amidohydro_1 PF01979.20 ORX54525.1 - 1.4e-16 60.7 0.0 7.5e-16 58.4 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX54525.1 - 2.5e-09 37.1 0.1 2.3e-07 30.7 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 ORX54528.1 - 1.4e-16 60.7 0.0 7.5e-16 58.4 0.0 2.1 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ORX54528.1 - 2.5e-09 37.1 0.1 2.3e-07 30.7 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family RhoGEF PF00621.20 ORX54529.1 - 3.7e-26 92.5 0.7 8e-26 91.4 0.2 1.8 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ORX54529.1 - 6.9e-06 26.5 0.0 1.2e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 PH domain IQ_SEC7_PH PF16453.5 ORX54529.1 - 0.00024 21.1 0.0 0.00049 20.1 0.0 1.5 1 0 0 1 1 1 1 PH domain Glyco_hydro_18 PF00704.28 ORX54530.1 - 4.5e-23 82.5 2.5 1.9e-22 80.4 2.4 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX54530.1 - 7.3e-13 48.3 13.6 7.3e-13 48.3 13.6 3.5 2 1 1 3 3 3 1 Carbohydrate binding domain (family 19) ARS2 PF04959.13 ORX54531.1 - 4.8e-20 72.8 0.1 4.8e-20 72.8 0.1 2.5 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF3546 PF12066.8 ORX54531.1 - 4.2e-19 68.8 2.2 4.2e-19 68.8 2.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3546) DUF4187 PF13821.6 ORX54531.1 - 1.3e-09 37.7 2.6 4e-09 36.1 2.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) RRM_1 PF00076.22 ORX54531.1 - 2.4e-06 27.3 0.0 5.8e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SUIM_assoc PF16619.5 ORX54531.1 - 0.019 15.0 1.0 0.068 13.2 1.0 2.0 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2729 PF10870.8 ORX54531.1 - 2.6 8.0 4.7 6.1 6.8 1.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2729) Gar1 PF04410.14 ORX54532.1 - 9.5e-39 132.6 0.0 1.2e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region AAA_2 PF07724.14 ORX54533.1 - 3.6e-43 147.6 0.0 5.8e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ORX54533.1 - 3.5e-16 59.8 0.0 7.3e-16 58.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ORX54533.1 - 1.3e-13 50.8 0.0 3.3e-13 49.5 0.0 1.7 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Mg_chelatase PF01078.21 ORX54533.1 - 1.7e-06 27.6 0.2 0.00053 19.4 0.0 2.9 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ORX54533.1 - 2.3e-05 24.7 0.3 0.00082 19.7 0.3 2.8 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ORX54533.1 - 4.6e-05 22.6 0.0 0.00014 21.1 0.0 1.8 2 0 0 2 2 2 1 Type II/IV secretion system protein Sigma54_activat PF00158.26 ORX54533.1 - 5.9e-05 22.8 0.2 0.021 14.6 0.0 3.0 3 1 0 3 3 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 ORX54533.1 - 0.00011 21.9 1.0 0.0022 17.7 0.2 2.8 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX54533.1 - 0.00016 21.7 0.3 0.0013 18.7 0.3 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ORX54533.1 - 0.0013 18.5 0.0 0.0023 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Sigma54_activ_2 PF14532.6 ORX54533.1 - 0.0013 18.8 0.0 0.0058 16.8 0.0 2.1 3 0 0 3 3 1 1 Sigma-54 interaction domain MCM PF00493.23 ORX54533.1 - 0.0026 16.9 0.3 0.0084 15.2 0.1 1.9 2 0 0 2 2 2 1 MCM P-loop domain AAA_14 PF13173.6 ORX54533.1 - 0.0027 17.7 0.0 0.0053 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX54533.1 - 0.0045 17.4 0.1 0.021 15.2 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ORX54533.1 - 0.0053 17.3 0.0 0.015 15.9 0.0 1.8 2 0 0 2 2 1 1 ABC transporter IstB_IS21 PF01695.17 ORX54533.1 - 0.0067 16.2 0.0 0.016 15.0 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 ORX54533.1 - 0.0071 15.9 0.0 0.017 14.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_3 PF07726.11 ORX54533.1 - 0.01 15.7 0.3 0.055 13.3 0.1 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ORX54533.1 - 0.016 15.0 0.2 0.12 12.2 0.0 2.4 1 1 0 2 2 2 0 DEAD/DEAH box helicase NACHT PF05729.12 ORX54533.1 - 0.024 14.5 0.1 0.094 12.6 0.1 2.1 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ORX54533.1 - 0.035 14.7 0.0 0.076 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ORX54533.1 - 0.038 13.4 0.0 0.073 12.5 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 ORX54533.1 - 0.048 13.0 0.1 0.84 8.9 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_10 PF12846.7 ORX54533.1 - 0.051 12.5 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain TsaE PF02367.17 ORX54533.1 - 0.066 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ORX54533.1 - 0.071 13.3 0.1 0.22 11.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX54533.1 - 0.073 13.5 0.0 0.26 11.7 0.0 2.0 2 0 0 2 2 1 0 RNA helicase ResIII PF04851.15 ORX54533.1 - 0.077 13.0 0.0 0.24 11.4 0.0 1.8 2 0 0 2 2 1 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 ORX54533.1 - 0.08 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ORX54533.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family CH PF00307.31 ORX54534.1 - 2e-47 159.9 0.4 6.5e-24 84.2 0.0 3.1 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 ORX54534.1 - 4.4e-17 61.9 0.2 4.8e-16 58.6 0.0 2.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 ORX54534.1 - 8.9e-14 51.1 0.1 5.2e-09 35.8 0.0 3.0 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 ORX54534.1 - 7.5e-07 28.6 0.2 8.9e-06 25.2 0.0 2.9 3 0 0 3 3 2 1 EF-hand domain EF-hand_1 PF00036.32 ORX54534.1 - 3.5e-06 26.2 0.2 1.9e-05 23.9 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_14 PF17959.1 ORX54534.1 - 0.00017 21.9 0.3 0.0065 16.8 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ORX54534.1 - 0.00079 19.2 0.1 0.069 13.0 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_7 PF13499.6 ORX54534.1 - 0.0014 19.0 1.2 0.0073 16.7 1.2 2.3 1 1 0 1 1 1 1 EF-hand domain pair CotJB PF12652.7 ORX54534.1 - 0.016 15.4 3.0 0.16 12.2 0.2 2.9 2 1 0 2 2 2 0 CotJB protein EF-hand_5 PF13202.6 ORX54534.1 - 0.02 14.3 0.0 0.085 12.4 0.0 2.2 1 0 0 1 1 1 0 EF hand Spectrin PF00435.21 ORX54534.1 - 0.022 15.2 13.5 0.033 14.7 4.3 3.5 1 1 1 3 3 3 0 Spectrin repeat ParD_antitoxin PF03693.14 ORX54534.1 - 0.1 13.0 0.0 0.51 10.8 0.0 2.2 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH EF-hand_11 PF08976.11 ORX54534.1 - 0.14 13.1 0.3 0.43 11.5 0.3 1.9 1 0 0 1 1 1 0 EF-hand domain Fib_alpha PF08702.10 ORX54534.1 - 0.15 12.3 9.7 4 7.6 0.5 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family JIP_LZII PF16471.5 ORX54534.1 - 0.64 10.2 3.3 0.5 10.6 1.0 2.1 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II SHE3 PF17078.5 ORX54534.1 - 0.7 9.6 16.9 2.2 8.0 7.9 2.9 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 ORX54534.1 - 1 8.1 14.0 0.8 8.5 8.8 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF745 PF05335.13 ORX54534.1 - 3.6 7.3 4.8 3.8 7.2 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) FliJ PF02050.16 ORX54534.1 - 5.5 7.2 17.7 1.8 8.8 5.0 3.1 3 0 0 3 3 3 0 Flagellar FliJ protein Homeodomain PF00046.29 ORX54536.1 - 4.3e-19 68.1 0.1 8.7e-19 67.1 0.1 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX54536.1 - 0.086 12.8 0.2 0.35 10.8 0.1 2.1 2 0 0 2 2 2 0 Homeobox KN domain MS_channel PF00924.18 ORX54537.1 - 8.3e-16 58.1 1.8 1.5e-15 57.3 1.8 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 ORX54537.1 - 0.00015 21.0 0.1 0.00042 19.7 0.1 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ORX54537.1 - 0.00043 20.0 0.1 0.0012 18.6 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ORX54537.1 - 0.0046 16.4 0.2 0.014 14.9 0.2 1.9 1 0 0 1 1 1 1 EF hand Claudin_2 PF13903.6 ORX54537.1 - 0.0077 16.0 0.1 0.0077 16.0 0.1 2.9 3 0 0 3 3 3 2 PMP-22/EMP/MP20/Claudin tight junction EF-hand_7 PF13499.6 ORX54537.1 - 0.062 13.8 0.1 0.18 12.3 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair DUF2207 PF09972.9 ORX54537.1 - 0.12 11.1 0.0 1.5 7.4 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Chitin_synth_2 PF03142.15 ORX54538.1 - 2.2e-239 795.5 0.4 2.9e-239 795.0 0.4 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX54538.1 - 4.4e-10 39.8 0.0 2.2e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX54538.1 - 2.2e-09 37.5 9.7 1.2e-08 35.1 9.7 2.2 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX54538.1 - 0.097 12.1 0.1 2.5 7.5 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 21 Sin_N PF04801.13 ORX54540.1 - 3.7e-51 174.7 3.6 4.8e-51 174.3 3.6 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region WASH-7_C PF14746.6 ORX54540.1 - 1.3 8.7 4.7 7.9 6.1 0.3 2.2 2 0 0 2 2 2 0 WASH complex subunit 7, C-terminal DUF5093 PF17011.5 ORX54540.1 - 9.8 6.5 7.6 2.6 8.3 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5093) Aph-1 PF06105.12 ORX54541.1 - 7.1e-39 133.6 15.6 1.8e-31 109.4 7.0 2.0 1 1 1 2 2 2 2 Aph-1 protein Fz PF01392.22 ORX54543.1 - 1e-06 29.3 2.2 1e-06 29.3 2.2 1.9 2 0 0 2 2 2 1 Fz domain 7tm_2 PF00002.24 ORX54543.1 - 9e-06 25.1 20.2 1.4e-05 24.6 20.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Orf78 PF06024.12 ORX54543.1 - 0.11 12.8 1.1 0.57 10.5 0.1 2.5 2 0 0 2 2 2 0 Orf78 (ac78) PMT_4TMC PF16192.5 ORX54544.1 - 8.5e-21 74.5 4.3 1.2e-20 74.0 4.3 1.2 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase PT PF04886.12 ORX54544.1 - 1.2 8.7 6.1 0.4 10.3 3.2 1.7 2 0 0 2 2 2 0 PT repeat PMT PF02366.18 ORX54545.1 - 3.8e-80 269.0 16.8 6.4e-80 268.3 16.8 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase MIR PF02815.19 ORX54545.1 - 4.4e-38 131.0 2.3 4.4e-38 131.0 2.3 1.5 2 0 0 2 2 2 1 MIR domain PMT_4TMC PF16192.5 ORX54545.1 - 1.6e-26 93.1 0.1 1.6e-26 93.1 0.1 2.2 3 0 0 3 3 3 1 C-terminal four TMM region of protein-O-mannosyltransferase PMT_2 PF13231.6 ORX54545.1 - 0.00074 19.8 16.8 0.097 12.9 10.3 3.8 3 1 0 3 3 3 2 Dolichyl-phosphate-mannose-protein mannosyltransferase COMPASS-Shg1 PF05205.12 ORX54546.1 - 2.3e-19 70.0 2.3 2.5e-19 69.9 2.3 1.0 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 CDPS PF16715.5 ORX54546.1 - 0.0087 15.7 0.0 0.0098 15.6 0.0 1.1 1 0 0 1 1 1 1 Cyclodipeptide synthase Hydrolase PF00702.26 ORX54547.1 - 2.7e-07 31.1 0.0 3.5e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX54547.1 - 6e-05 23.2 0.0 8.1e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX54547.1 - 0.015 15.3 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like RL PF17797.1 ORX54547.1 - 0.055 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 RL domain Cation_efflux PF01545.21 ORX54548.1 - 5.9e-52 176.3 14.7 1e-51 175.6 14.7 1.4 1 0 0 1 1 1 1 Cation efflux family Fungal_trans PF04082.18 ORX54549.1 - 1.8e-30 105.9 0.0 4.6e-30 104.6 0.0 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain YafO_toxin PF13957.6 ORX54549.1 - 0.015 15.3 0.0 0.042 13.9 0.0 1.7 2 0 0 2 2 2 0 Toxin YafO, type II toxin-antitoxin system Topoisom_I PF01028.20 ORX54550.1 - 1.2e-95 319.2 7.1 2.3e-95 318.2 7.1 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 ORX54550.1 - 1.9e-91 305.3 2.3 1.9e-91 305.3 2.3 3.0 3 0 0 3 3 3 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 ORX54550.1 - 4.4e-33 113.0 1.3 1.6e-32 111.2 1.3 2.1 1 0 0 1 1 1 1 C-terminal topoisomerase domain zf-H2C2_2 PF13465.6 ORX54551.1 - 3.8e-11 42.9 16.6 4.3e-05 23.7 0.3 4.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX54551.1 - 9.3e-11 41.6 24.2 3.8e-06 27.0 0.3 4.2 4 0 0 4 4 4 3 Zinc finger, C2H2 type FOXP-CC PF16159.5 ORX54551.1 - 7.2e-06 26.5 8.9 0.31 11.7 0.1 4.0 1 1 3 4 4 4 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX54551.1 - 9.6e-05 22.9 20.3 0.0027 18.4 0.2 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX54551.1 - 0.004 17.4 6.3 0.0058 16.9 6.3 1.4 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX54551.1 - 0.045 13.8 0.0 0.045 13.8 0.0 3.2 3 2 0 3 3 3 0 C2H2-type zinc finger zf_CopZ PF18423.1 ORX54551.1 - 0.059 13.3 0.5 5.2 7.1 0.0 2.4 2 0 0 2 2 2 0 Zinc binding domain zf-C2H2_jaz PF12171.8 ORX54551.1 - 0.11 12.9 0.1 0.11 12.9 0.1 3.5 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX54551.1 - 0.11 12.9 2.5 7.7 7.1 0.0 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_ZIC PF18366.1 ORX54551.1 - 1.7 8.8 10.2 27 4.9 0.0 4.1 3 1 0 4 4 4 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 ORX54551.1 - 3 7.9 7.8 17 5.5 0.8 2.8 1 1 1 3 3 3 0 Aberrant zinc-finger PQ-loop PF04193.14 ORX54552.1 - 3.4e-34 116.4 14.0 1.5e-17 63.1 1.6 2.5 2 0 0 2 2 2 2 PQ loop repeat YmcE_antitoxin PF15939.5 ORX54552.1 - 0.042 14.0 0.9 0.33 11.1 0.2 2.3 1 1 1 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system PQ-loop PF04193.14 ORX54554.1 - 2.4e-35 120.1 13.3 2.2e-17 62.6 1.0 2.5 2 0 0 2 2 2 2 PQ loop repeat DUF4448 PF14610.6 ORX54554.1 - 0.17 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) PQ-loop PF04193.14 ORX54556.1 - 2.2e-37 126.6 17.2 9.6e-20 70.1 5.7 2.6 2 0 0 2 2 2 2 PQ loop repeat SieB PF14163.6 ORX54556.1 - 0.71 9.4 3.4 0.26 10.8 0.1 1.9 2 0 0 2 2 2 0 Super-infection exclusion protein B Aminotran_4 PF01063.19 ORX54557.1 - 4.1e-24 85.7 0.0 5e-24 85.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Zn_clus PF00172.18 ORX54558.1 - 7.5e-12 45.2 8.4 8.9e-12 44.9 8.4 1.1 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX54559.1 - 4.6e-09 35.7 0.3 4.6e-09 35.7 0.3 2.0 3 0 0 3 3 3 1 Fungal specific transcription factor domain FAD-oxidase_C PF02913.19 ORX54561.1 - 1.2e-60 205.3 0.0 1.6e-60 204.8 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ORX54561.1 - 1.1e-36 125.6 0.3 1.8e-36 124.9 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Glyco_hydro_20 PF00728.22 ORX54561.1 - 0.069 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain Lipase_3 PF01764.25 ORX54562.1 - 4.4e-06 26.6 0.0 7.7e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ORX54562.1 - 0.061 13.9 1.0 0.098 13.2 0.1 1.7 2 0 0 2 2 2 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX54562.1 - 0.093 12.0 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 ORX54562.1 - 0.12 12.3 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) PGAP1 PF07819.13 ORX54562.1 - 0.18 11.5 0.0 0.38 10.4 0.0 1.6 2 0 0 2 2 2 0 PGAP1-like protein FAD_binding_6 PF00970.24 ORX54563.1 - 4.7e-28 97.4 0.0 7.2e-28 96.8 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ORX54563.1 - 4.9e-28 98.0 0.0 7.8e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ORX54563.1 - 3.8e-09 36.8 0.0 8e-07 29.3 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 ORX54563.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain Polysacc_deac_1 PF01522.21 ORX54564.1 - 2e-25 89.1 0.0 4.2e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ORX54564.1 - 0.00013 21.3 0.0 0.0003 20.1 0.0 1.5 1 1 1 2 2 2 1 Glycosyl hydrolase family 57 Sugar_tr PF00083.24 ORX54566.1 - 6e-106 355.0 29.9 5.5e-78 262.8 17.2 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX54566.1 - 4.5e-24 85.0 18.4 4.5e-24 85.0 18.4 2.3 2 0 0 2 2 2 1 Major Facilitator Superfamily PSI PF01437.25 ORX54566.1 - 0.00032 21.2 3.8 0.00053 20.5 3.8 1.3 1 0 0 1 1 1 1 Plexin repeat RRM_1 PF00076.22 ORX54567.1 - 6.7e-19 67.5 0.2 8.8e-19 67.1 0.2 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ORX54567.1 - 0.00018 21.5 0.1 0.00026 21.0 0.1 1.3 1 0 0 1 1 1 1 RNA binding motif Nup35_RRM_2 PF14605.6 ORX54567.1 - 0.0005 20.0 0.1 0.0009 19.2 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ORX54567.1 - 0.0064 16.6 0.1 0.019 15.1 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 ORX54567.1 - 0.022 14.3 0.0 0.027 14.1 0.0 1.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ORX54567.1 - 0.076 13.2 0.0 2.3 8.4 0.0 2.0 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RRM_9 PF18444.1 ORX54567.1 - 0.15 12.0 0.1 0.23 11.3 0.1 1.3 1 1 0 1 1 1 0 RNA recognition motif Zn_clus PF00172.18 ORX54568.1 - 1.7e-06 28.1 12.0 3.9e-06 26.9 12.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4113 PF13438.6 ORX54568.1 - 0.16 12.1 0.2 0.39 10.8 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4113) TFIIA PF03153.13 ORX54568.1 - 6.7 6.6 26.5 14 5.5 26.5 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RabGAP-TBC PF00566.18 ORX54569.1 - 5e-30 104.8 0.2 5e-30 104.8 0.2 2.6 3 0 0 3 3 3 1 Rab-GTPase-TBC domain CdvA PF18822.1 ORX54569.1 - 0.69 9.7 14.1 0.044 13.6 6.1 2.7 1 1 1 2 2 2 0 CdvA-like coiled-coil domain WIYLD PF10440.9 ORX54571.1 - 0.012 15.4 0.2 0.048 13.5 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain SWIM PF04434.17 ORX54575.1 - 0.07 12.8 0.4 0.14 11.8 0.4 1.5 1 0 0 1 1 1 0 SWIM zinc finger AAA PF00004.29 ORX54576.1 - 2.5e-17 63.5 0.0 5.6e-17 62.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX54576.1 - 3.4e-05 23.9 0.0 0.00019 21.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ORX54576.1 - 6.9e-05 23.2 0.0 0.00022 21.6 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 ORX54576.1 - 0.00063 20.2 0.8 0.0024 18.3 0.0 2.4 3 1 0 3 3 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX54576.1 - 0.002 18.4 0.1 0.78 10.0 0.0 2.9 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 ORX54576.1 - 0.003 16.8 0.0 0.006 15.8 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ORX54576.1 - 0.0052 16.5 0.0 0.02 14.6 0.0 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 ORX54576.1 - 0.0064 16.0 0.0 0.02 14.4 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_18 PF13238.6 ORX54576.1 - 0.0068 17.0 3.3 0.0077 16.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain NARP1 PF12569.8 ORX54576.1 - 0.0079 15.2 2.7 0.013 14.4 2.7 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 RNA_pol_3_Rpc31 PF11705.8 ORX54576.1 - 0.0086 16.3 6.1 0.0086 16.3 6.1 1.7 2 0 0 2 2 1 1 DNA-directed RNA polymerase III subunit Rpc31 RuvB_N PF05496.12 ORX54576.1 - 0.011 15.4 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain RsgA_GTPase PF03193.16 ORX54576.1 - 0.016 15.1 0.0 0.055 13.4 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 ORX54576.1 - 0.028 14.6 0.0 0.068 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX54576.1 - 0.033 14.4 0.0 0.033 14.4 0.0 2.3 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 ORX54576.1 - 0.041 13.8 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_tran PF00005.27 ORX54576.1 - 0.047 14.2 0.1 0.13 12.8 0.1 1.8 1 1 0 1 1 1 0 ABC transporter PPV_E1_C PF00519.17 ORX54576.1 - 0.048 12.5 0.0 0.089 11.6 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase IstB_IS21 PF01695.17 ORX54576.1 - 0.05 13.3 0.0 0.36 10.6 0.0 2.3 1 1 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ORX54576.1 - 0.089 12.2 0.0 0.22 10.9 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 ORX54576.1 - 0.11 11.6 0.0 0.24 10.4 0.0 1.5 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 MMR_HSR1 PF01926.23 ORX54576.1 - 0.12 12.4 0.0 0.41 10.7 0.0 1.9 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX54576.1 - 0.17 11.6 0.0 0.17 11.6 0.0 2.0 3 0 0 3 3 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3449 PF11931.8 ORX54576.1 - 0.24 11.2 7.6 8.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) DUF1682 PF07946.14 ORX54576.1 - 0.27 10.4 6.5 0.5 9.5 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) AAA_11 PF13086.6 ORX54576.1 - 0.33 10.7 10.9 2.9 7.6 10.9 2.2 1 1 0 1 1 1 0 AAA domain FYDLN_acid PF09538.10 ORX54576.1 - 0.58 10.9 13.0 0.31 11.7 6.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) AAA_23 PF13476.6 ORX54576.1 - 1.4 9.3 17.6 47 4.4 17.6 2.7 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ORX54577.1 - 2.5e-19 70.0 0.0 4.9e-19 69.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ORX54577.1 - 9.9e-06 24.9 0.0 1.6e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 ORX54577.1 - 0.00012 22.5 0.1 0.00085 19.7 0.1 2.5 2 1 0 2 2 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX54577.1 - 0.00031 21.0 0.4 0.39 11.0 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 ORX54577.1 - 0.00085 19.3 0.0 0.0029 17.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX54577.1 - 0.0012 18.6 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ORX54577.1 - 0.0022 17.7 0.2 0.011 15.5 0.2 1.9 1 1 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX54577.1 - 0.0055 17.1 0.0 0.017 15.5 0.0 1.9 1 0 0 1 1 1 1 RNA helicase AAA_19 PF13245.6 ORX54577.1 - 0.0063 16.9 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ORX54577.1 - 0.0069 16.2 0.0 0.014 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ORX54577.1 - 0.0072 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 ORX54577.1 - 0.0076 16.8 0.0 0.028 15.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ORX54577.1 - 0.0091 16.5 0.0 0.029 14.9 0.0 1.8 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ORX54577.1 - 0.0092 15.7 0.0 0.021 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 ORX54577.1 - 0.03 14.2 0.2 0.42 10.5 0.0 2.7 2 2 1 3 3 3 0 Rad17 P-loop domain RsgA_GTPase PF03193.16 ORX54577.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase MMR_HSR1 PF01926.23 ORX54577.1 - 0.059 13.5 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMC_N PF02463.19 ORX54577.1 - 0.081 12.3 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Glyco_hydro_49 PF03718.13 ORX54577.1 - 0.089 12.8 0.0 0.64 10.0 0.0 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 PPV_E1_C PF00519.17 ORX54577.1 - 0.11 11.3 0.3 0.46 9.3 0.0 2.0 3 0 0 3 3 3 0 Papillomavirus helicase Bac_DnaA PF00308.18 ORX54577.1 - 0.11 12.3 0.1 0.59 9.9 0.1 2.0 1 1 0 1 1 1 0 Bacterial dnaA protein AAA_28 PF13521.6 ORX54577.1 - 0.13 12.5 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Tom22 PF04281.13 ORX54577.1 - 0.15 11.9 0.5 0.4 10.5 0.5 1.8 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 AAA_30 PF13604.6 ORX54577.1 - 0.16 11.6 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX54578.1 - 1.7e-17 64.1 0.0 5.3e-17 62.5 0.0 1.9 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BCS1_N PF08740.11 ORX54578.1 - 5.3e-06 26.5 0.1 5.3e-06 26.5 0.1 1.8 2 0 0 2 2 2 1 BCS1 N terminal AAA_5 PF07728.14 ORX54578.1 - 3e-05 24.0 0.0 6.9e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ORX54578.1 - 6.5e-05 22.2 0.0 0.00015 21.0 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ORX54578.1 - 0.00014 21.6 0.2 0.00062 19.5 0.2 1.9 1 1 0 1 1 1 1 IstB-like ATP binding protein RuvB_N PF05496.12 ORX54578.1 - 0.0021 17.8 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ORX54578.1 - 0.0043 17.4 0.2 0.022 15.1 0.0 2.3 2 1 0 2 2 2 1 RNA helicase AAA_11 PF13086.6 ORX54578.1 - 0.0062 16.4 5.3 0.097 12.4 0.0 2.7 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 ORX54578.1 - 0.0076 16.8 0.1 0.028 15.0 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ORX54578.1 - 0.0092 16.4 0.3 0.22 11.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 ORX54578.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ORX54578.1 - 0.027 14.0 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PnpCD_PnpD_N PF18191.1 ORX54578.1 - 0.042 13.4 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 Hydroquinone 1,2-dioxygenase large subunit N-terminal AAA_18 PF13238.6 ORX54578.1 - 0.047 14.2 0.7 0.36 11.4 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 ORX54578.1 - 0.059 13.7 0.3 3.9 7.7 0.0 2.6 1 1 1 2 2 2 0 AAA domain FAM176 PF14851.6 ORX54578.1 - 8.4 6.0 10.2 21 4.8 10.2 1.6 1 0 0 1 1 1 0 FAM176 family B56 PF01603.20 ORX54579.1 - 4.1e-167 556.4 7.4 5.5e-167 555.9 7.4 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RPN13_C PF16550.5 ORX54579.1 - 0.028 14.6 1.1 1.5 9.0 0.0 2.8 2 0 0 2 2 2 0 UCH-binding domain Porin_3 PF01459.22 ORX54580.1 - 2.1e-67 227.4 7.6 2.4e-67 227.3 7.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin Caps_assemb_Wzi PF14052.6 ORX54580.1 - 0.017 14.2 0.1 0.031 13.3 0.1 1.3 1 0 0 1 1 1 0 Capsule assembly protein Wzi Tox-REase-2 PF15646.6 ORX54580.1 - 0.069 13.3 0.1 1.1 9.5 0.0 2.1 1 1 0 2 2 2 0 Restriction endonuclease fold toxin 2 DUF2013 PF09431.10 ORX54581.1 - 4.1e-44 150.1 8.0 4.1e-44 150.1 8.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) FA_hydroxylase PF04116.13 ORX54582.1 - 2.7e-22 79.5 12.3 2.7e-22 79.5 12.3 2.6 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Clat_adaptor_s PF01217.20 ORX54583.1 - 4.8e-30 104.4 0.0 5.3e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF1281 PF06924.11 ORX54583.1 - 0.0015 18.1 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1281) HOCHOB PF17943.1 ORX54583.1 - 0.049 14.4 0.1 0.087 13.5 0.1 1.4 1 0 0 1 1 1 0 Homeobox-cysteine loop-homeobox AP-5_subunit_s1 PF15001.6 ORX54583.1 - 0.12 12.4 0.0 0.63 10.0 0.0 1.9 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 AA_permease PF00324.21 ORX54584.1 - 2.1e-125 419.0 43.4 2.7e-125 418.7 43.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX54584.1 - 1.9e-51 175.3 48.1 2.3e-51 175.0 48.1 1.0 1 0 0 1 1 1 1 Amino acid permease RNA_pol_Rpb1_1 PF04997.12 ORX54585.1 - 2.5e-90 303.0 0.0 3.9e-90 302.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 ORX54585.1 - 2.4e-83 279.6 0.3 3.5e-83 279.1 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ORX54585.1 - 7.7e-75 250.7 0.0 1.3e-74 249.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ORX54585.1 - 2.1e-37 128.5 0.0 1.3e-36 126.0 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 ORX54585.1 - 8.7e-30 102.9 0.2 2.5e-29 101.4 0.2 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Rpr2 PF04032.16 ORX54585.1 - 0.25 11.7 3.8 0.72 10.2 0.9 2.5 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Lipase_GDSL_2 PF13472.6 ORX54586.1 - 0.0004 20.8 0.0 0.00057 20.3 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Aa_trans PF01490.18 ORX54587.1 - 1.3e-80 271.1 34.5 1.5e-80 270.9 34.5 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 ORX54587.1 - 1.6e-06 27.3 41.5 1.6e-05 24.0 41.5 2.0 1 1 0 1 1 1 1 Amino acid permease MutL_C PF08676.11 ORX54588.1 - 2.2e-12 46.9 0.5 6.7e-09 35.7 0.1 2.4 2 0 0 2 2 2 2 MutL C terminal dimerisation domain CBS PF00571.28 ORX54589.1 - 1.6e-32 111.8 8.4 3e-08 34.0 0.0 5.5 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 ORX54589.1 - 3.9e-07 29.9 2.0 1.1e-06 28.4 2.0 1.9 1 1 0 1 1 1 1 PB1 domain GAF PF01590.26 ORX54589.1 - 0.017 15.7 0.1 16 6.2 0.0 3.2 3 0 0 3 3 3 0 GAF domain Ribosomal_S11 PF00411.19 ORX54590.1 - 1.7e-24 86.4 0.1 2.6e-24 85.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Elong-fact-P_C PF09285.11 ORX54591.1 - 3.4e-13 49.1 0.1 1.1e-12 47.5 0.0 1.9 2 0 0 2 2 2 1 Elongation factor P, C-terminal EFP_N PF08207.12 ORX54591.1 - 8e-12 45.0 0.1 1.8e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain EFP PF01132.20 ORX54591.1 - 1.2e-07 31.7 0.1 2.3e-07 30.7 0.1 1.5 1 0 0 1 1 1 1 Elongation factor P (EF-P) OB domain PTR2 PF00854.21 ORX54592.1 - 1.8e-90 303.6 19.2 2.8e-90 303.0 19.2 1.3 1 0 0 1 1 1 1 POT family YpmT PF17431.2 ORX54592.1 - 3.5 7.7 5.8 2.1 8.5 1.8 2.7 2 0 0 2 2 2 0 Uncharacterized YmpT-like LysM PF01476.20 ORX54594.1 - 1.6e-07 31.3 0.0 5e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 LysM domain SpoIIP PF07454.11 ORX54594.1 - 0.038 13.5 0.0 0.052 13.0 0.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAD_binding_3 PF01494.19 ORX54595.1 - 1.3e-40 139.8 0.0 1.8e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX54595.1 - 4.5e-07 29.8 0.0 0.00043 20.0 0.0 2.3 1 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX54595.1 - 1.9e-05 23.6 0.1 0.00029 19.7 0.1 2.1 2 0 0 2 2 2 1 HI0933-like protein Phe_hydrox_dim PF07976.12 ORX54595.1 - 0.0003 20.8 0.0 0.014 15.4 0.0 2.7 2 0 0 2 2 2 1 Phenol hydroxylase, C-terminal dimerisation domain NAD_binding_8 PF13450.6 ORX54595.1 - 0.00031 20.9 0.0 0.00077 19.6 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX54595.1 - 0.00098 18.4 0.1 0.0015 17.8 0.1 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 ORX54595.1 - 0.0022 17.3 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ORX54595.1 - 0.0037 17.7 0.0 0.0075 16.7 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ORX54595.1 - 0.0081 15.3 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX54595.1 - 0.0082 15.4 0.1 0.032 13.4 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 ORX54595.1 - 0.009 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX54595.1 - 0.015 14.6 0.0 0.026 13.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.27 ORX54595.1 - 0.025 15.1 0.0 0.077 13.6 0.0 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase ThiF PF00899.21 ORX54595.1 - 0.026 13.9 0.0 0.057 12.8 0.0 1.5 1 0 0 1 1 1 0 ThiF family Lycopene_cycl PF05834.12 ORX54595.1 - 0.041 12.9 0.0 0.069 12.2 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein UDPG_MGDP_dh_N PF03721.14 ORX54595.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain XdhC_C PF13478.6 ORX54595.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain ApbA PF02558.16 ORX54595.1 - 0.12 12.1 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 ORX54595.1 - 0.22 10.8 0.1 0.42 9.9 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase ELO PF01151.18 ORX54596.1 - 3.4e-20 72.6 19.9 4.1e-20 72.4 19.9 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Ras PF00071.22 ORX54597.1 - 9.3e-66 220.4 0.6 1.1e-65 220.2 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX54597.1 - 9.9e-37 125.8 0.1 1.7e-36 125.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX54597.1 - 4.7e-18 65.3 0.3 5.5e-18 65.0 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX54597.1 - 4.8e-06 26.6 1.3 0.047 13.6 0.3 2.3 1 1 1 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX54597.1 - 7.6e-06 25.6 0.5 1.5e-05 24.6 0.3 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX54597.1 - 9.6e-06 25.1 0.1 1.4e-05 24.6 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX54597.1 - 9.8e-06 25.1 0.1 1.2e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX54597.1 - 1.6e-05 25.0 0.1 5.1e-05 23.3 0.0 1.8 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX54597.1 - 0.0022 17.5 0.2 0.013 15.0 0.2 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 ORX54597.1 - 0.0023 18.3 0.0 0.0033 17.8 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ORX54597.1 - 0.0025 18.2 0.1 0.49 10.8 0.0 2.2 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATP_bind_1 PF03029.17 ORX54597.1 - 0.0048 16.7 0.3 0.012 15.5 0.1 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Septin PF00735.18 ORX54597.1 - 0.0052 16.1 0.2 0.15 11.4 0.0 2.2 2 1 0 2 2 2 1 Septin AAA_5 PF07728.14 ORX54597.1 - 0.014 15.4 0.0 0.029 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ORX54597.1 - 0.042 14.4 0.1 0.11 13.0 0.1 1.9 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 ORX54597.1 - 0.045 13.5 0.0 1.2 8.9 0.0 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ORX54597.1 - 0.046 14.0 0.0 0.088 13.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ORX54597.1 - 0.058 13.2 0.1 0.16 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 ORX54597.1 - 0.058 12.8 0.0 0.26 10.6 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 ORX54597.1 - 0.06 12.9 0.2 1.1 8.8 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX54597.1 - 0.075 12.5 0.0 0.17 11.4 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Globin PF00042.22 ORX54598.1 - 0.00023 21.7 0.0 0.0016 19.0 0.0 2.0 2 0 0 2 2 2 1 Globin zf-C2H2_jaz PF12171.8 ORX54599.1 - 0.0015 18.8 1.4 1 9.7 0.0 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX54599.1 - 0.013 15.5 0.9 0.013 15.5 0.9 2.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX54599.1 - 0.16 12.5 11.3 2.6 8.7 1.1 3.0 2 0 0 2 2 2 0 Zinc finger, C2H2 type G-gamma PF00631.22 ORX54601.1 - 3.2e-18 65.5 0.3 3.8e-18 65.3 0.3 1.1 1 0 0 1 1 1 1 GGL domain HPS3_N PF14761.6 ORX54601.1 - 0.082 12.4 0.0 0.095 12.2 0.0 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 DUF4248 PF14053.6 ORX54601.1 - 0.1 12.6 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) YL1 PF05764.13 ORX54602.1 - 3.4e-35 122.3 28.7 4.1e-35 122.1 28.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein YL1_C PF08265.11 ORX54602.1 - 1.1e-11 44.3 0.3 1.7e-11 43.6 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain KCT2 PF17818.1 ORX54602.1 - 0.56 10.3 2.8 1.2 9.2 2.8 1.5 1 0 0 1 1 1 0 Keratinocyte-associated gene product Pox_Ag35 PF03286.14 ORX54603.1 - 0.031 14.1 0.4 0.052 13.3 0.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein OrfB_Zn_ribbon PF07282.11 ORX54604.1 - 1e-09 38.1 2.3 2.2e-09 37.1 2.3 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX54604.1 - 0.044 13.5 0.6 0.074 12.7 0.6 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal DUF4503 PF14951.6 ORX54604.1 - 0.14 10.6 2.1 0.21 10.0 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) His_biosynth PF00977.21 ORX54604.1 - 0.21 11.0 0.0 1.3 8.4 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein SPA PF08616.10 ORX54605.1 - 5.3e-37 126.3 0.0 1.1e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis Afi1 PF07792.12 ORX54605.1 - 7.7e-23 81.4 0.1 1e-19 71.3 0.1 2.4 1 1 1 2 2 2 2 Docking domain of Afi1 for Arf3 in vesicle trafficking Avl9 PF09794.9 ORX54605.1 - 4.5e-11 42.1 0.0 2.2e-05 23.4 0.0 3.3 2 1 1 3 3 3 2 Transport protein Avl9 DUF2347 PF09804.9 ORX54605.1 - 9.2e-07 28.7 0.0 0.0036 16.9 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2347) TPR_2 PF07719.17 ORX54606.1 - 1.9e-13 49.4 7.7 8.3e-06 25.5 0.3 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX54606.1 - 3.2e-13 48.9 9.4 2.2e-07 30.4 0.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX54606.1 - 8.3e-10 38.1 5.5 8e-05 22.6 0.3 3.8 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX54606.1 - 1.4e-07 31.7 2.2 0.016 15.8 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX54606.1 - 1.3e-05 25.4 6.6 0.005 17.1 2.0 3.9 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX54606.1 - 3.3e-05 23.5 3.2 0.00088 18.9 0.2 2.8 3 0 0 3 3 3 1 TPR repeat PB1 PF00564.24 ORX54606.1 - 4.2e-05 23.4 0.0 9.8e-05 22.2 0.0 1.6 1 0 0 1 1 1 1 PB1 domain TPR_7 PF13176.6 ORX54606.1 - 0.0013 18.6 7.0 0.032 14.3 0.2 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX54606.1 - 0.0029 18.2 5.4 0.022 15.4 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX54606.1 - 0.003 17.4 0.7 0.016 15.1 0.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX54606.1 - 0.024 15.4 2.9 0.3 12.0 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX54606.1 - 0.027 14.8 3.7 18 6.0 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX54606.1 - 0.044 14.3 4.0 0.046 14.2 0.3 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_4 PF07721.14 ORX54606.1 - 0.055 14.1 0.1 0.71 10.7 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ORX54606.1 - 0.41 10.8 1.8 15 5.9 1.1 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX54606.1 - 0.69 10.2 4.8 2.2 8.6 0.9 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Omega-toxin PF06357.11 ORX54607.1 - 0.098 12.5 0.8 0.14 11.9 0.8 1.2 1 0 0 1 1 1 0 Omega-atracotoxin DEK_C PF08766.11 ORX54608.1 - 1.8e-07 31.0 0.4 4.8e-07 29.6 0.4 1.7 1 0 0 1 1 1 1 DEK C terminal domain CHZ PF09649.10 ORX54608.1 - 0.00016 21.0 2.5 0.0004 19.8 2.5 1.6 1 0 0 1 1 1 1 Histone chaperone domain CHZ Roughex PF06020.11 ORX54608.1 - 1.3 8.1 23.0 0.15 11.1 13.5 2.2 2 0 0 2 2 2 0 Drosophila roughex protein Macoilin PF09726.9 ORX54608.1 - 2 6.9 18.6 2.4 6.6 18.6 1.2 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 ORX54608.1 - 9.4 4.3 37.0 0.22 9.7 23.4 2.1 2 0 0 2 2 2 0 Nop14-like family DUF4407 PF14362.6 ORX54608.1 - 10 5.4 13.3 0.33 10.3 2.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) CENP-O PF09496.10 ORX54609.1 - 1.4e-12 48.0 0.7 4.3e-12 46.5 0.7 1.7 1 1 0 1 1 1 1 Cenp-O kinetochore centromere component RNB PF00773.19 ORX54610.1 - 1.5e-101 340.0 0.3 2.6e-101 339.2 0.3 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX54610.1 - 7.6e-22 77.1 0.0 1.6e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ORX54610.1 - 4.6e-12 46.1 0.0 3.4e-11 43.3 0.0 2.5 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 ORX54610.1 - 2.9e-05 24.1 0.1 0.014 15.6 0.0 2.9 3 0 0 3 3 3 2 Cold shock domain Rrp44_CSD1 PF17216.3 ORX54610.1 - 0.001 18.8 0.0 0.0025 17.6 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Peptidase_C78 PF07910.13 ORX54611.1 - 7e-54 182.5 0.1 1.5e-53 181.5 0.1 1.5 2 0 0 2 2 2 1 Peptidase family C78 Peptidase_C54 PF03416.19 ORX54611.1 - 0.046 13.1 0.1 0.064 12.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase family C54 Trans_reg_C PF00486.28 ORX54611.1 - 0.073 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulatory protein, C terminal HSP70 PF00012.20 ORX54612.1 - 8.1e-271 899.5 9.1 9.4e-271 899.3 9.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX54612.1 - 8.3e-15 54.4 1.5 3.2e-12 45.9 0.4 2.5 2 1 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 ORX54612.1 - 0.0019 18.0 0.0 0.0049 16.6 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.11 ORX54612.1 - 0.0039 16.5 0.1 0.23 10.7 0.0 2.4 1 1 1 2 2 2 2 StbA protein FtsA PF14450.6 ORX54612.1 - 0.0066 16.8 5.2 0.52 10.8 0.0 3.6 3 2 0 3 3 3 2 Cell division protein FtsA Med9 PF07544.13 ORX54612.1 - 0.13 12.4 1.4 0.42 10.7 1.4 1.9 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Peroxin-22 PF12827.7 ORX54613.1 - 0.0051 16.7 0.4 0.011 15.6 0.4 1.4 1 1 0 1 1 1 1 Peroxisomal biogenesis protein family Asp PF00026.23 ORX54614.1 - 3.3e-77 260.0 11.4 4.2e-77 259.6 11.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX54614.1 - 4.4e-10 40.1 10.1 2e-07 31.4 0.1 4.5 2 2 2 4 4 4 3 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX54614.1 - 0.00018 21.3 1.2 0.0008 19.2 1.2 2.0 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal adh_short_C2 PF13561.6 ORX54616.1 - 4.9e-42 144.1 0.0 2e-40 138.8 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX54616.1 - 1.5e-41 142.0 0.0 2e-41 141.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX54616.1 - 1.4e-09 38.1 0.0 2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX54616.1 - 0.024 14.0 0.0 0.033 13.6 0.0 1.3 1 1 0 1 1 1 0 Fungal family of unknown function (DUF1776) Shikimate_DH PF01488.20 ORX54616.1 - 0.13 12.3 0.1 0.32 11.1 0.1 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase CHCH PF06747.13 ORX54617.1 - 0.00012 22.1 9.5 0.0002 21.4 9.5 1.4 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 ORX54617.1 - 0.00022 21.4 4.4 0.00032 20.8 4.4 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 ORX54617.1 - 0.036 14.4 6.1 0.05 13.9 6.1 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein PET191 NDK PF00334.19 ORX54618.1 - 2.1e-50 170.2 0.0 3.1e-50 169.7 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ras PF00071.22 ORX54619.1 - 5.6e-54 182.1 0.0 6.4e-54 181.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX54619.1 - 1.5e-22 80.0 0.0 2.3e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX54619.1 - 2.6e-08 33.5 0.0 3.5e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 ORX54619.1 - 0.11 12.2 0.0 4.5 7.0 0.0 2.9 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ING PF12998.7 ORX54620.1 - 1.2e-17 64.3 2.4 1.2e-17 64.3 2.4 1.5 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX54620.1 - 9.8e-06 25.4 8.6 2.2e-05 24.3 8.6 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX54620.1 - 0.00013 21.4 1.5 0.00029 20.3 1.5 1.6 1 0 0 1 1 1 1 PHD-finger Med30 PF11315.8 ORX54620.1 - 0.026 14.7 0.8 0.037 14.2 0.3 1.4 1 1 0 1 1 1 0 Mediator complex subunit 30 zf-4CXXC_R1 PF10497.9 ORX54620.1 - 0.037 14.2 1.9 1.9 8.8 1.8 2.9 3 0 0 3 3 3 0 Zinc-finger domain of monoamine-oxidase A repressor R1 MSA-2c PF12238.8 ORX54620.1 - 0.044 13.8 0.2 0.061 13.3 0.2 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c RAG2_PHD PF13341.6 ORX54620.1 - 0.062 13.4 0.6 0.14 12.2 0.6 1.6 1 0 0 1 1 1 0 RAG2 PHD domain Tma16 PF11176.8 ORX54620.1 - 0.072 13.0 0.6 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Cyclin_C_2 PF16899.5 ORX54621.1 - 6.5e-14 52.2 0.7 1.4e-11 44.7 0.0 2.9 2 1 1 3 3 3 1 Cyclin C-terminal domain Cyclin_N PF00134.23 ORX54621.1 - 2.9e-09 36.7 1.0 1.8e-08 34.2 0.4 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain IL28A PF15177.6 ORX54621.1 - 0.03 14.1 0.3 0.11 12.3 0.0 1.9 2 0 0 2 2 2 0 Interleukin-28A TFIIB PF00382.19 ORX54621.1 - 0.046 13.8 0.0 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Transcription factor TFIIB repeat FAR1 PF03101.15 ORX54622.1 - 2.7e-06 28.0 1.5 5.2e-06 27.1 1.5 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain DUF2205 PF10224.9 ORX54623.1 - 1.1e-08 34.9 0.0 1.3e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Short coiled-coil protein JIP_LZII PF16471.5 ORX54623.1 - 0.046 13.9 0.0 0.052 13.7 0.0 1.1 1 0 0 1 1 1 0 JNK-interacting protein leucine zipper II LRR_4 PF12799.7 ORX54624.1 - 0.00015 22.1 6.2 0.21 12.1 0.1 3.9 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX54624.1 - 0.00033 20.5 6.2 10 6.5 0.2 5.5 5 0 0 5 5 5 3 Leucine Rich repeat FCH PF00611.23 ORX54625.1 - 2.5e-12 46.9 2.0 1.2e-11 44.7 0.0 2.9 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain muHD PF10291.9 ORX54625.1 - 3.5e-10 39.8 0.0 7.2e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain NosD PF05048.13 ORX54626.1 - 0.0044 16.3 1.4 0.16 11.2 0.2 2.3 2 0 0 2 2 2 2 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 ORX54626.1 - 0.013 15.4 9.4 0.11 12.3 2.6 2.9 2 1 0 2 2 2 0 Right handed beta helix region Methyltransf_11 PF08241.12 ORX54627.1 - 1.4e-20 73.8 0.0 2.1e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX54627.1 - 1.1e-16 61.1 0.0 1.9e-16 60.3 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX54627.1 - 1.8e-15 57.4 0.0 3e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX54627.1 - 1.4e-12 48.2 0.0 2.4e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX54627.1 - 2.1e-11 43.8 0.0 4.4e-11 42.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX54627.1 - 1.1e-07 31.4 0.0 1.8e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ORX54627.1 - 1.2e-05 24.7 0.0 1.6e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.13 ORX54627.1 - 4e-05 23.1 0.0 5.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 ORX54627.1 - 8.5e-05 21.6 0.0 0.00014 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 ORX54627.1 - 0.0011 18.6 0.0 0.0021 17.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ORX54627.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 ORX54627.1 - 0.012 14.7 0.0 0.031 13.4 0.0 1.5 1 1 0 1 1 1 0 DREV methyltransferase TehB PF03848.14 ORX54627.1 - 0.032 13.7 0.0 0.054 12.9 0.0 1.3 1 1 0 1 1 1 0 Tellurite resistance protein TehB WD40 PF00400.32 ORX54628.1 - 4.4e-08 33.7 1.7 0.0057 17.5 0.1 3.2 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF2415 PF10313.9 ORX54628.1 - 9.7e-06 25.4 2.6 0.00012 21.9 0.2 2.9 3 0 0 3 3 3 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 ORX54628.1 - 0.00062 20.0 0.0 8.4 6.8 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX54628.1 - 0.005 15.4 0.2 0.008 14.8 0.2 1.2 1 0 0 1 1 1 1 Cytochrome D1 heme domain HEAT PF02985.22 ORX54629.1 - 1e-36 121.8 17.8 0.00092 19.3 0.0 13.0 13 1 0 13 13 13 7 HEAT repeat HEAT_2 PF13646.6 ORX54629.1 - 5.3e-34 116.5 1.0 1.1e-06 28.9 0.0 6.2 2 1 6 8 8 8 8 HEAT repeats HEAT_EZ PF13513.6 ORX54629.1 - 5e-13 49.2 9.9 5.4e-06 26.8 0.1 6.9 6 3 3 9 9 9 3 HEAT-like repeat Adaptin_N PF01602.20 ORX54629.1 - 2.1e-09 36.5 4.2 0.0098 14.5 0.0 3.5 1 1 1 3 3 3 3 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 ORX54629.1 - 2e-08 34.7 1.7 0.12 13.0 0.0 5.7 4 2 2 6 6 6 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX54629.1 - 2.8e-07 30.7 10.7 0.071 13.2 0.2 5.1 2 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ORX54629.1 - 2.1e-06 27.9 5.9 1.8 8.7 0.1 5.5 2 1 3 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 ORX54629.1 - 3.2e-05 23.8 1.6 4 7.6 0.0 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 ORX54629.1 - 7.4e-05 22.4 0.3 2.1 7.8 0.1 4.0 1 1 4 5 5 5 2 CLASP N terminal HEAT_PBS PF03130.16 ORX54629.1 - 0.14 12.9 0.2 12 6.9 0.0 3.9 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF2924 PF11149.8 ORX54631.1 - 0.033 14.6 0.1 0.041 14.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2924) ParB PF08775.10 ORX54631.1 - 0.064 13.7 1.5 0.079 13.4 1.5 1.2 1 0 0 1 1 1 0 ParB family FtsK_SpoIIIE_N PF12538.8 ORX54631.1 - 0.12 12.6 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 DNA transporter DUF4218 PF13960.6 ORX54633.1 - 5.4e-05 22.8 0.0 0.00012 21.6 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4218) WD40 PF00400.32 ORX54634.1 - 5.6e-16 58.6 9.4 4e-05 24.3 0.2 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat F-box-like PF12937.7 ORX54634.1 - 8.6e-10 38.4 3.1 2.6e-09 36.8 3.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX54634.1 - 1.2e-05 25.1 0.9 2.9e-05 23.8 0.9 1.7 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 ORX54634.1 - 0.024 14.9 0.1 3.1 8.1 0.1 2.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 ORX54634.1 - 0.081 12.8 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 F-box Glyco_hydro_47 PF01532.20 ORX54910.1 - 4e-147 490.8 0.1 4.6e-147 490.6 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 ORX54910.1 - 0.16 10.5 0.0 0.27 9.7 0.0 1.3 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 bZIP_2 PF07716.15 ORX54911.1 - 3.4e-08 33.4 13.7 4.4e-08 33.1 10.1 1.9 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX54911.1 - 2.6e-07 30.6 10.0 2.8e-07 30.5 10.0 1.0 1 0 0 1 1 1 1 bZIP transcription factor Cep57_CLD_2 PF14197.6 ORX54911.1 - 0.00022 21.2 5.9 0.00028 20.9 5.9 1.4 1 1 0 1 1 1 1 Centrosome localisation domain of PPC89 DUF5101 PF17031.5 ORX54911.1 - 0.0013 18.8 0.5 0.0014 18.6 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5101) bZIP_Maf PF03131.17 ORX54911.1 - 0.0034 17.8 10.6 0.0039 17.7 10.6 1.0 1 0 0 1 1 1 1 bZIP Maf transcription factor HALZ PF02183.18 ORX54911.1 - 0.0037 17.5 2.7 0.15 12.3 0.4 2.3 1 1 1 2 2 2 1 Homeobox associated leucine zipper IKKbetaNEMObind PF12179.8 ORX54911.1 - 0.0058 16.6 1.4 0.011 15.7 1.4 1.6 1 0 0 1 1 1 1 I-kappa-kinase-beta NEMO binding domain Csm1_N PF18504.1 ORX54911.1 - 0.013 15.8 3.9 0.013 15.8 3.9 1.8 1 1 1 2 2 2 0 Csm1 N-terminal domain KIAA1430 PF13879.6 ORX54911.1 - 0.024 15.4 7.1 0.03 15.1 7.1 1.2 1 0 0 1 1 1 0 KIAA1430 homologue UPF0242 PF06785.11 ORX54911.1 - 0.079 13.1 6.4 0.087 12.9 6.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Rootletin PF15035.6 ORX54911.1 - 0.086 12.9 10.4 0.2 11.7 10.4 1.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion NRBF2 PF08961.10 ORX54911.1 - 0.09 12.4 6.6 0.096 12.3 6.6 1.1 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Macoilin PF09726.9 ORX54911.1 - 0.18 10.4 9.9 0.18 10.3 9.9 1.0 1 0 0 1 1 1 0 Macoilin family FapA PF03961.13 ORX54911.1 - 0.24 10.0 4.9 0.25 9.9 4.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 ORX54911.1 - 4.8 7.0 8.7 9.7 6.1 5.5 2.4 1 1 1 2 2 2 0 Septum formation initiator Img2 PF05046.14 ORX54912.1 - 8.4e-26 90.1 0.0 1.3e-25 89.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) Polysacc_lyase PF14099.6 ORX54912.1 - 0.006 16.5 0.7 0.023 14.6 0.7 1.7 1 1 1 2 2 2 1 Polysaccharide lyase Adaptin_N PF01602.20 ORX54913.1 - 6.8e-149 496.8 10.0 8.1e-149 496.5 10.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ORX54913.1 - 3.4e-22 78.9 0.5 8.7e-22 77.5 0.5 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 ORX54913.1 - 1.9e-09 37.8 6.5 4.1e-09 36.7 0.9 3.2 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX54913.1 - 9.3e-05 22.7 1.2 0.71 10.3 0.1 3.9 3 1 1 4 4 4 2 HEAT repeats RIX1 PF08167.12 ORX54913.1 - 0.0031 17.3 0.1 0.034 13.9 0.1 2.7 1 1 0 1 1 1 1 rRNA processing/ribosome biogenesis Mu-like_Pro PF10123.9 ORX54913.1 - 0.12 11.9 0.3 3 7.3 0.1 2.6 2 0 0 2 2 2 0 Mu-like prophage I protein Calpain_inhib PF00748.19 ORX54913.1 - 2.8 8.4 10.6 4.1 7.9 4.6 2.6 1 1 1 2 2 2 0 Calpain inhibitor 4HBT PF03061.22 ORX54914.1 - 6.5e-14 52.1 0.1 8.2e-14 51.7 0.1 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Neisseria_PilC PF05567.11 ORX54914.1 - 0.043 12.8 0.0 0.048 12.6 0.0 1.0 1 0 0 1 1 1 0 Neisseria PilC beta-propeller domain AAA PF00004.29 ORX54915.1 - 2.6e-62 209.1 0.0 1.3e-43 148.5 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 ORX54915.1 - 2.4e-29 101.6 0.4 6.3e-29 100.2 0.4 1.8 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 ORX54915.1 - 7.8e-13 48.0 0.0 2.9e-07 30.2 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX54915.1 - 1.3e-08 35.5 10.0 0.016 15.6 0.0 5.4 3 2 3 6 6 5 2 AAA ATPase domain Viral_helicase1 PF01443.18 ORX54915.1 - 4e-06 26.7 0.0 0.032 14.0 0.0 2.7 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 ORX54915.1 - 1.2e-05 25.4 0.0 0.13 12.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 ORX54915.1 - 1.3e-05 25.4 0.0 0.061 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ORX54915.1 - 2.3e-05 25.0 0.0 0.14 12.7 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_22 PF13401.6 ORX54915.1 - 3.7e-05 24.0 0.7 0.88 9.8 0.1 3.9 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 ORX54915.1 - 4.7e-05 23.4 0.1 0.56 10.2 0.0 3.1 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) TsaE PF02367.17 ORX54915.1 - 5.6e-05 23.1 0.5 0.27 11.2 0.0 3.2 3 0 0 3 3 3 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 ORX54915.1 - 0.00035 20.4 0.2 0.1 12.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX54915.1 - 0.00037 20.7 1.5 0.038 14.2 0.0 3.4 3 1 0 3 3 3 1 AAA domain RuvB_N PF05496.12 ORX54915.1 - 0.00043 20.1 0.0 0.003 17.3 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ORX54915.1 - 0.0018 18.6 0.0 0.98 9.8 0.0 2.8 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 ORX54915.1 - 0.002 17.3 0.0 0.17 11.0 0.0 2.9 3 0 0 3 3 2 1 Protein of unknown function (DUF815) UFD1 PF03152.14 ORX54915.1 - 0.0034 16.9 0.0 0.18 11.3 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin fusion degradation protein UFD1 NACHT PF05729.12 ORX54915.1 - 0.0035 17.3 1.7 3.1 7.7 0.2 3.4 3 1 0 3 3 3 1 NACHT domain Mg_chelatase PF01078.21 ORX54915.1 - 0.0052 16.2 0.3 0.73 9.2 0.0 3.3 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ORX54915.1 - 0.0085 15.3 0.0 0.1 11.8 0.0 2.3 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_17 PF13207.6 ORX54915.1 - 0.012 16.0 0.1 0.34 11.3 0.0 2.9 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 ORX54915.1 - 0.013 15.4 0.1 0.56 10.1 0.0 2.6 2 0 0 2 2 2 0 NTPase AAA_3 PF07726.11 ORX54915.1 - 0.014 15.3 0.0 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX54915.1 - 0.018 14.8 0.3 4.5 7.0 0.0 3.1 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 ORX54915.1 - 0.03 14.6 0.0 8.2 6.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ORX54915.1 - 0.034 13.7 4.3 1.5 8.4 0.1 3.7 2 2 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 ORX54915.1 - 0.036 13.3 0.3 2.8 7.2 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin T2SSE PF00437.20 ORX54915.1 - 0.051 12.6 0.3 0.33 10.0 0.0 2.3 2 1 0 2 2 2 0 Type II/IV secretion system protein CDC48_2 PF02933.17 ORX54915.1 - 0.057 13.2 0.0 0.15 11.8 0.0 1.7 1 1 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 ATPase_2 PF01637.18 ORX54915.1 - 0.079 12.9 0.0 9.5 6.1 0.0 2.9 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 ORX54915.1 - 0.1 12.5 0.0 0.46 10.4 0.0 2.1 2 0 0 2 2 1 0 Rad17 P-loop domain Bac_DnaA PF00308.18 ORX54915.1 - 0.11 12.4 0.0 13 5.6 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein cobW PF02492.19 ORX54915.1 - 0.11 12.1 0.2 2.7 7.5 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain HLH PF00010.26 ORX54916.1 - 9.6e-14 51.1 1.6 9.6e-14 51.1 1.6 2.0 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain UPF0242 PF06785.11 ORX54916.1 - 0.62 10.1 14.6 4.1 7.5 14.6 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NRBF2 PF08961.10 ORX54916.1 - 0.78 9.3 9.7 1.1 8.9 9.1 1.6 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Strabismus PF06638.11 ORX54916.1 - 2.2 6.8 7.7 8 5.0 6.5 1.8 1 1 1 2 2 2 0 Strabismus protein Slu7 PF11708.8 ORX54917.1 - 1.3e-105 353.0 16.4 2.1e-105 352.3 16.4 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC_4 PF14392.6 ORX54917.1 - 0.024 14.4 0.4 0.045 13.5 0.4 1.4 1 0 0 1 1 1 0 Zinc knuckle TMEM154 PF15102.6 ORX54919.1 - 0.033 14.1 0.5 0.068 13.1 0.2 1.6 1 1 0 1 1 1 0 TMEM154 protein family Ribosomal_L22e PF01776.17 ORX54920.1 - 3.4e-48 162.5 1.9 4e-48 162.3 1.9 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Metallophos PF00149.28 ORX54921.1 - 7e-13 49.5 1.6 1.2e-12 48.7 1.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AP_endonuc_2 PF01261.24 ORX54921.1 - 0.042 13.3 0.0 0.12 11.8 0.0 1.6 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel MFS_1 PF07690.16 ORX54922.1 - 7.4e-20 71.2 24.5 9.3e-20 70.8 24.5 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ORX54922.1 - 0.17 10.1 5.7 0.3 9.3 5.7 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Holin_9 PF16936.5 ORX54922.1 - 0.84 9.8 5.6 4.9 7.4 1.9 2.8 2 1 0 2 2 2 0 Putative holin SdpI PF13630.6 ORX54922.1 - 1.9 8.7 11.9 1.6 8.9 3.2 2.9 2 0 0 2 2 2 0 SdpI/YhfL protein family BcrAD_BadFG PF01869.20 ORX54923.1 - 5.9e-15 55.5 1.3 9.8e-15 54.8 1.3 1.3 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family SIS PF01380.22 ORX54923.1 - 3.6e-06 26.8 0.0 2.4e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 SIS domain SIS_2 PF13580.6 ORX54923.1 - 0.00062 19.8 0.1 0.0061 16.6 0.0 2.5 3 0 0 3 3 3 1 SIS domain MFS_1 PF07690.16 ORX54924.1 - 3.5e-12 45.9 35.3 4.5e-09 35.7 20.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 ORX54924.1 - 8.6e-10 38.5 16.3 1.1e-09 38.2 9.8 2.5 2 0 0 2 2 2 2 Ion channel regulatory protein UNC-93 Steroid_dh PF02544.16 ORX54924.1 - 1.6e-05 24.9 2.9 6.1e-05 23.0 0.1 2.7 2 1 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase Adaptin_N PF01602.20 ORX54925.1 - 3.6e-118 395.4 4.5 4.7e-118 395.0 4.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ORX54925.1 - 1.4e-23 83.2 0.0 4.9e-23 81.5 0.0 1.9 2 0 0 2 2 2 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ORX54925.1 - 2.9e-17 63.0 0.1 6.5e-17 61.8 0.1 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain LRR_6 PF13516.6 ORX54926.1 - 1.9e-21 74.2 10.9 0.00015 21.5 0.0 8.1 8 0 0 8 8 8 5 Leucine Rich repeat LRR_4 PF12799.7 ORX54926.1 - 5.9e-12 45.6 16.6 0.02 15.3 0.0 6.4 5 2 2 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX54926.1 - 2e-07 30.6 6.7 14 6.7 0.0 7.6 7 1 0 7 7 7 2 Leucine Rich Repeat LRR_8 PF13855.6 ORX54926.1 - 2.5e-05 23.9 17.0 2.5 7.9 0.2 6.5 5 2 1 6 6 6 5 Leucine rich repeat Pil1 PF13805.6 ORX54927.1 - 4.5e-32 111.6 0.6 4.5e-32 111.6 0.6 1.7 2 0 0 2 2 2 1 Eisosome component PIL1 STAT_alpha PF01017.20 ORX54927.1 - 0.015 15.2 0.5 0.028 14.3 0.5 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain HAP1_N PF04849.13 ORX54927.1 - 0.033 13.4 1.2 0.053 12.7 1.2 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ATG16 PF08614.11 ORX54927.1 - 0.11 12.7 0.3 0.11 12.7 0.3 3.2 4 0 0 4 4 4 0 Autophagy protein 16 (ATG16) COX6C PF02937.15 ORX54927.1 - 0.19 11.9 0.1 0.36 11.0 0.1 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VIc Laminin_II PF06009.12 ORX54927.1 - 0.43 10.6 2.6 5.2 7.1 1.1 2.2 2 0 0 2 2 2 0 Laminin Domain II HORMA PF02301.18 ORX54928.1 - 2.8e-20 72.8 1.0 7.3e-20 71.5 1.0 1.6 1 1 0 1 1 1 1 HORMA domain bacHORMA_2 PF18173.1 ORX54928.1 - 0.0035 17.2 0.5 0.0064 16.4 0.1 1.6 2 0 0 2 2 2 1 Bacterial HORMA domain 2 zf-CCHC PF00098.23 ORX54929.1 - 1.4e-05 24.9 2.8 4e-05 23.5 2.8 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_3 PF13920.6 ORX54929.1 - 0.00016 21.5 11.5 0.00016 21.5 11.5 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.6 ORX54929.1 - 0.00016 21.6 0.4 0.00043 20.2 0.4 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_2 PF13696.6 ORX54929.1 - 0.00026 20.7 12.0 0.00073 19.3 12.0 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-RING_2 PF13639.6 ORX54929.1 - 0.0015 18.8 12.2 0.0032 17.7 12.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX54929.1 - 0.01 15.7 13.3 0.01 15.7 13.3 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) DUF5318 PF17249.2 ORX54929.1 - 0.043 13.6 1.2 0.44 10.3 0.0 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5318) zf-RING_5 PF14634.6 ORX54929.1 - 0.2 11.7 18.2 0.084 12.8 13.4 2.5 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX54929.1 - 0.36 10.9 10.3 0.9 9.6 10.3 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_4 PF14570.6 ORX54929.1 - 0.91 9.4 11.3 0.33 10.8 5.6 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-C3HC4 PF00097.25 ORX54929.1 - 1.4 8.9 20.8 0.048 13.5 14.8 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TFIIA PF03153.13 ORX54929.1 - 2.5 8.0 31.6 3.2 7.7 21.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Chitin_synth_2 PF03142.15 ORX54930.1 - 4.2e-242 804.4 0.1 5.8e-242 804.0 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX54930.1 - 2.4e-34 118.7 0.0 7.7e-34 116.9 0.0 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) Cyt-b5 PF00173.28 ORX54930.1 - 2.2e-15 56.6 2.1 2.8e-11 43.4 0.1 3.9 3 1 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain DEK_C PF08766.11 ORX54930.1 - 7.8e-15 54.5 1.0 8.7e-14 51.2 0.1 3.0 3 0 0 3 3 3 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 ORX54930.1 - 9.7e-13 48.5 0.0 3.3e-11 43.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX54930.1 - 1.5e-10 41.3 1.0 5.4e-10 39.5 1.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX54930.1 - 3.3e-06 27.0 0.0 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX54930.1 - 0.091 12.2 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 21 RhoGEF PF00621.20 ORX54931.1 - 8.2e-16 58.8 0.0 1.5e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ORX54931.1 - 0.027 15.0 0.2 0.14 12.7 0.2 2.2 1 1 0 1 1 1 0 PH domain PH_13 PF16652.5 ORX54931.1 - 0.46 10.3 3.3 1 9.1 1.4 2.6 3 1 0 3 3 3 0 Pleckstrin homology domain NRDE-2 PF08424.10 ORX54932.1 - 2.3e-87 293.1 3.7 2.3e-87 293.1 3.7 2.8 3 0 0 3 3 3 1 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 ORX54932.1 - 5e-07 30.0 0.4 1.5 9.8 0.0 6.4 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX54932.1 - 0.011 14.9 0.6 0.088 12.0 0.1 2.7 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX54932.1 - 0.039 14.5 0.2 30 5.2 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX54932.1 - 0.91 8.8 4.9 5.3 6.3 0.3 3.4 3 1 0 3 3 3 0 MalT-like TPR region CDC45 PF02724.14 ORX54933.1 - 1.4 7.1 9.3 1.6 7.0 9.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ORX54933.1 - 1.6 7.4 5.8 1.9 7.2 5.8 1.0 1 0 0 1 1 1 0 Presenilin Apt1 PF10351.9 ORX54933.1 - 1.9 7.2 9.6 2 7.2 9.6 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S28 PF05577.12 ORX54934.1 - 2.5e-69 234.1 0.0 3.2e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 ORX54934.1 - 4.6e-06 25.6 2.1 1.3e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 PS-10 peptidase S37 Abhydrolase_1 PF00561.20 ORX54934.1 - 0.00092 18.9 0.0 0.0018 18.0 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX54934.1 - 0.057 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family MNE1 PF13762.6 ORX54935.1 - 0.069 13.1 0.6 0.18 11.8 0.6 1.8 1 1 0 1 1 1 0 Mitochondrial splicing apparatus component GPI-anchored PF10342.9 ORX54936.1 - 3.9e-12 46.8 2.5 3.9e-12 46.8 2.5 2.1 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family He_PIG PF05345.12 ORX54936.1 - 0.0063 16.7 3.7 0.0063 16.7 3.7 2.7 3 0 0 3 3 3 1 Putative Ig domain DUF4448 PF14610.6 ORX54936.1 - 0.011 15.5 0.1 0.015 15.1 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) F-box-like PF12937.7 ORX54937.1 - 1.2e-09 37.8 1.2 5.6e-08 32.6 0.3 2.7 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 ORX54937.1 - 0.00063 19.5 0.1 0.00063 19.5 0.1 2.0 2 0 0 2 2 2 1 F-box domain Ribosomal_L6e PF01159.19 ORX54940.1 - 7.2e-35 119.9 2.1 7.2e-35 119.9 2.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L6e Ribosomal_L6e_N PF03868.15 ORX54940.1 - 2.3e-11 43.8 0.7 2.3e-11 43.8 0.7 3.0 3 1 0 3 3 3 1 Ribosomal protein L6, N-terminal domain KOW PF00467.29 ORX54940.1 - 0.043 13.8 1.8 0.046 13.7 0.1 2.0 2 0 0 2 2 2 0 KOW motif Asp PF00026.23 ORX54941.1 - 7.8e-114 380.3 0.0 9.2e-114 380.1 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX54941.1 - 8.3e-13 49.0 0.7 1.5e-10 41.6 0.7 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX54941.1 - 0.001 18.9 0.0 0.0024 17.7 0.0 1.7 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp PF00026.23 ORX54942.1 - 0.00015 21.3 0.0 0.011 15.2 0.0 2.0 2 0 0 2 2 2 2 Eukaryotic aspartyl protease Aminotran_1_2 PF00155.21 ORX54944.1 - 2.1e-78 264.0 0.0 2.7e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX54944.1 - 4.3e-05 22.2 0.0 7.2e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ORX54944.1 - 4.5e-05 22.6 0.1 0.00065 18.8 0.0 2.2 1 1 1 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 ORX54944.1 - 0.0023 17.3 0.1 0.0046 16.3 0.1 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Preseq_ALAS PF09029.10 ORX54944.1 - 0.005 17.3 0.4 0.01 16.3 0.4 1.4 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence DUF3405 PF11885.8 ORX54944.1 - 0.055 12.1 0.6 0.1 11.2 0.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3405) DegT_DnrJ_EryC1 PF01041.17 ORX54944.1 - 0.056 12.7 0.3 0.16 11.3 0.3 1.7 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Sec20 PF03908.13 ORX54945.1 - 2.4e-19 69.0 9.4 2.8e-19 68.8 0.5 2.5 2 0 0 2 2 2 1 Sec20 Ost4 PF10215.9 ORX54945.1 - 0.012 15.4 0.4 0.023 14.5 0.4 1.4 1 0 0 1 1 1 0 Oligosaccaryltransferase PhoU_div PF01865.16 ORX54945.1 - 0.08 12.3 3.1 0.11 11.8 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF47 mCpol PF18182.1 ORX54945.1 - 0.15 12.4 1.4 6.7 7.1 0.3 2.5 2 0 0 2 2 2 0 minimal CRISPR polymerase domain DUF4407 PF14362.6 ORX54945.1 - 0.72 9.2 8.1 1 8.7 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5344 PF17279.2 ORX54945.1 - 0.91 10.1 8.4 1.2 9.8 2.9 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Exonuc_VII_L PF02601.15 ORX54945.1 - 4.9 6.6 11.5 8 5.9 11.5 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 ORX54945.1 - 7.4 6.0 9.2 2 7.9 4.5 2.0 1 1 0 2 2 2 0 Allexivirus 40kDa protein Thaumatin PF00314.17 ORX54946.1 - 1.2e-43 149.3 14.5 8e-43 146.6 14.5 1.9 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 ORX54946.1 - 0.00027 20.4 1.2 0.44 9.8 0.0 2.3 2 0 0 2 2 2 2 Beta-1,3-glucanase efThoc1 PF11957.8 ORX54947.1 - 1.9e-86 290.7 1.4 2.9e-86 290.1 1.4 1.2 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor POT1PC PF16686.5 ORX54948.1 - 1.9e-08 34.3 0.4 4.2e-08 33.2 0.1 1.7 2 0 0 2 2 2 1 ssDNA-binding domain of telomere protection protein PH PF00169.29 ORX54949.1 - 1.8e-42 144.1 4.5 4.3e-21 75.4 0.1 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ORX54949.1 - 6.6e-14 52.2 14.4 3.2e-06 27.5 5.9 4.1 2 2 0 2 2 2 2 Pleckstrin homology domain PH_3 PF14593.6 ORX54949.1 - 1.7e-13 50.5 8.0 1.9e-08 34.3 2.5 2.2 2 0 0 2 2 2 2 PH domain PH_8 PF15409.6 ORX54949.1 - 4.7e-13 49.2 5.4 1e-05 25.7 2.7 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_9 PF15410.6 ORX54949.1 - 8.6e-09 35.8 6.8 9.2e-05 22.8 2.5 3.9 2 2 0 2 2 2 2 Pleckstrin homology domain Myosin_TH1 PF06017.13 ORX54949.1 - 0.00078 19.2 1.0 1.6 8.4 0.0 2.8 2 1 1 3 3 3 2 Unconventional myosin tail, actin- and lipid-binding Mcp5_PH PF12814.7 ORX54949.1 - 0.0011 19.1 2.7 0.22 11.6 0.5 2.6 2 0 0 2 2 2 2 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 ORX54949.1 - 0.025 14.4 2.5 3.4 7.5 0.9 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_12 PF16457.5 ORX54949.1 - 0.041 14.4 1.7 6.5 7.3 0.0 3.5 2 2 0 3 3 3 0 Pleckstrin homology domain BCL_N PF04714.13 ORX54949.1 - 0.15 12.1 4.0 0.83 9.8 1.1 2.4 2 0 0 2 2 2 0 BCL7, N-terminal conserver region Peptidase_S9 PF00326.21 ORX54950.1 - 1.2e-06 28.2 0.0 2.8e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ORX54950.1 - 0.0015 17.8 0.1 0.078 12.2 0.1 2.4 1 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX54950.1 - 0.016 14.9 0.6 0.59 9.7 0.1 2.9 2 1 1 3 3 3 0 alpha/beta hydrolase fold DUF1057 PF06342.12 ORX54950.1 - 0.04 13.0 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Glyco_hydro_38N PF01074.22 ORX54951.1 - 1.6e-59 201.6 1.3 6.3e-59 199.7 0.1 2.3 2 1 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ORX54951.1 - 2.1e-49 168.5 0.0 3.1e-49 167.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ORX54951.1 - 4e-22 78.2 0.0 1.6e-21 76.3 0.0 2.1 2 0 0 2 2 2 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ORX54951.1 - 7.5e-13 48.4 0.0 1.7e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF3603 PF12227.8 ORX54951.1 - 0.13 11.6 0.4 0.25 10.6 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3603) WLM PF08325.10 ORX54952.1 - 3.2e-42 144.8 0.1 5.5e-42 144.0 0.1 1.4 1 0 0 1 1 1 1 WLM domain ubiquitin PF00240.23 ORX54952.1 - 6.7e-11 41.8 0.0 1.2e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 ORX54952.1 - 0.096 13.1 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD PF11976.8 ORX54952.1 - 0.14 12.0 0.0 0.58 10.0 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF45 PF01863.17 ORX54952.1 - 0.35 10.9 3.8 0.34 10.9 0.7 2.3 2 1 1 3 3 3 0 Protein of unknown function DUF45 Ribosomal_L15e PF00827.17 ORX54953.1 - 4.7e-89 297.2 9.0 5.3e-89 297.0 9.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 Adap_comp_sub PF00928.21 ORX54954.1 - 1.5e-93 313.0 0.1 2e-93 312.6 0.1 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX54954.1 - 1.1e-08 35.1 0.4 2e-08 34.3 0.4 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RecU PF03838.14 ORX54954.1 - 0.1 12.6 0.4 13 5.7 0.0 3.3 3 1 0 3 3 3 0 Recombination protein U Metallophos PF00149.28 ORX54955.1 - 1.4e-12 48.6 0.5 2.1e-12 48.0 0.5 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX54955.1 - 2.2e-08 34.5 0.2 3.3e-08 33.9 0.2 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CotH PF08757.11 ORX54963.1 - 1.3e-22 80.8 0.2 2.2e-16 60.3 0.5 2.2 1 1 1 2 2 2 2 CotH kinase protein Peptidase_C54 PF03416.19 ORX54964.1 - 1.9e-45 155.4 0.0 2.4e-45 155.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C54 PF03416.19 ORX54965.1 - 0.0022 17.4 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 Med9 PF07544.13 ORX54966.1 - 6.5e-12 45.4 1.6 9.8e-12 44.8 1.6 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 CMD PF02627.20 ORX54967.1 - 0.0022 18.0 0.1 0.0067 16.5 0.0 1.8 2 0 0 2 2 2 1 Carboxymuconolactone decarboxylase family DNA_pol3_gamma3 PF12169.8 ORX54967.1 - 0.075 12.9 0.3 0.14 12.1 0.3 1.4 1 0 0 1 1 1 0 DNA polymerase III subunits gamma and tau domain III Adaptin_N PF01602.20 ORX54968.1 - 4.5e-136 454.5 16.4 4.6e-135 451.1 14.2 2.0 1 1 1 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 ORX54968.1 - 1.7e-60 203.8 10.0 3.2e-59 199.6 3.4 2.7 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX54968.1 - 1.2e-16 60.9 1.1 6.9e-06 26.4 0.0 6.3 3 2 4 7 7 7 3 HEAT repeats HEAT PF02985.22 ORX54968.1 - 1.6e-08 34.1 3.4 0.00072 19.6 0.0 6.5 7 0 0 7 7 7 1 HEAT repeat HEAT_EZ PF13513.6 ORX54968.1 - 0.00034 21.0 0.3 0.42 11.2 0.0 4.7 4 1 1 5 5 5 1 HEAT-like repeat CLASP_N PF12348.8 ORX54968.1 - 0.00063 19.4 0.3 0.058 12.9 0.0 3.2 2 2 1 3 3 3 1 CLASP N terminal RhoGEF PF00621.20 ORX54968.1 - 0.0083 16.4 0.5 0.043 14.1 0.2 2.3 2 0 0 2 2 2 1 RhoGEF domain Arm PF00514.23 ORX54968.1 - 0.016 15.2 0.9 30 4.8 0.0 4.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ORX54968.1 - 0.02 14.9 0.3 0.27 11.3 0.1 3.0 2 1 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain RRM_1 PF00076.22 ORX54969.1 - 1.9e-14 53.2 0.0 3e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COS PF18568.1 ORX54969.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 TRIM C-terminal subgroup One Signature domain FAP PF07174.11 ORX54969.1 - 0.27 10.6 10.6 0.42 10.0 10.6 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Homeodomain PF00046.29 ORX54970.1 - 5e-16 58.3 0.4 6.9e-16 57.8 0.4 1.2 1 0 0 1 1 1 1 Homeodomain Herpes_UL32 PF06070.11 ORX54970.1 - 0.0077 14.1 0.1 0.0099 13.7 0.1 1.1 1 0 0 1 1 1 1 Herpesvirus large structural phosphoprotein UL32 Homeobox_KN PF05920.11 ORX54970.1 - 0.13 12.1 0.5 0.26 11.2 0.5 1.6 1 1 0 1 1 1 0 Homeobox KN domain LIM PF00412.22 ORX54972.1 - 3.1e-13 49.7 14.3 3.2e-09 36.9 7.3 2.7 2 1 0 2 2 2 2 LIM domain HEAT PF02985.22 ORX54973.1 - 7.5 7.1 6.2 1e+02 3.6 0.0 4.9 5 0 0 5 5 5 0 HEAT repeat OrfB_Zn_ribbon PF07282.11 ORX54974.1 - 0.00018 21.4 0.1 0.00023 21.0 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain UPF0126 PF03458.13 ORX54975.1 - 0.019 14.8 1.6 0.22 11.4 0.3 2.4 2 0 0 2 2 2 0 UPF0126 domain RXT2_N PF08595.11 ORX54976.1 - 6.5e-15 55.5 9.8 4e-14 52.9 0.3 2.9 1 1 2 3 3 3 2 RXT2-like, N-terminal zf-RING_2 PF13639.6 ORX54977.1 - 1e-06 29.0 7.6 4.9e-06 26.8 7.6 2.0 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX54977.1 - 4.3e-06 26.9 5.6 7.2e-06 26.2 5.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX54977.1 - 3.8e-05 23.5 2.5 8.4e-05 22.4 2.5 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX54977.1 - 4.7e-05 23.1 3.5 4.7e-05 23.1 3.5 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX54977.1 - 0.0002 21.0 1.2 0.0002 21.0 1.2 2.2 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_5 PF14634.6 ORX54977.1 - 0.00071 19.5 7.0 0.0027 17.6 7.2 1.9 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX54977.1 - 0.0016 18.3 5.1 0.15 12.0 3.7 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX54977.1 - 0.0035 17.4 5.0 0.0071 16.4 5.1 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX54977.1 - 0.018 15.1 3.8 0.029 14.4 0.8 2.3 2 0 0 2 2 2 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ORX54977.1 - 0.029 14.0 4.2 0.029 14.0 4.2 1.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Pellino PF04710.14 ORX54977.1 - 0.037 12.7 1.1 0.049 12.3 1.1 1.1 1 0 0 1 1 1 0 Pellino zf-RING_9 PF13901.6 ORX54977.1 - 0.064 13.2 3.3 0.097 12.6 3.3 1.3 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon FANCL_C PF11793.8 ORX54977.1 - 0.084 13.1 6.8 3.4 7.9 6.8 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain zf-Di19 PF05605.12 ORX54977.1 - 0.085 13.2 2.3 1 9.7 0.1 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DZR PF12773.7 ORX54977.1 - 0.48 10.5 3.6 1.3 9.1 3.6 1.6 1 1 0 1 1 1 0 Double zinc ribbon zf-UDP PF14569.6 ORX54977.1 - 0.86 9.8 6.9 0.74 10.0 4.8 2.0 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-C3HC4_3 PF13920.6 ORX54977.1 - 0.99 9.3 8.1 7.9 6.4 8.2 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.6 ORX54977.1 - 3 7.8 8.4 2.1 8.3 2.7 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 Pkinase PF00069.25 ORX54978.1 - 7.8e-75 251.6 0.0 9.8e-75 251.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54978.1 - 2.8e-37 128.4 0.0 3.7e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX54978.1 - 0.00022 20.7 0.0 0.00041 19.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX54978.1 - 0.0032 17.4 0.1 0.0075 16.2 0.1 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family FTA2 PF13095.6 ORX54978.1 - 0.017 14.8 0.2 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SQS_PSY PF00494.19 ORX54979.1 - 3.2e-24 85.9 0.0 4e-24 85.5 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase HLH PF00010.26 ORX54980.1 - 1.8e-17 63.0 3.8 3.5e-17 62.1 3.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4363 PF14276.6 ORX54980.1 - 0.15 12.2 0.2 0.21 11.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Aa_trans PF01490.18 ORX54982.1 - 1.3e-58 198.6 26.8 1.5e-58 198.5 26.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Cytochrom_B_C PF00032.17 ORX54982.1 - 9.4 6.6 10.5 35 4.8 5.6 3.7 3 1 0 3 3 3 0 Cytochrome b(C-terminal)/b6/petD Phytochelatin PF05023.14 ORX54983.1 - 8.8e-70 234.2 0.0 3.6e-37 127.7 0.0 2.3 1 1 1 2 2 2 2 Phytochelatin synthase Peptidase_C39_2 PF13529.6 ORX54983.1 - 0.0089 16.6 0.1 0.22 12.1 0.0 2.4 1 1 0 2 2 2 1 Peptidase_C39 like family WD40 PF00400.32 ORX54984.1 - 2e-51 170.8 24.0 1.4e-08 35.2 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX54984.1 - 2.4e-11 43.8 3.0 0.082 13.2 0.0 5.1 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX54984.1 - 5.8e-06 26.3 0.1 4.3e-05 23.5 0.1 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX54984.1 - 0.00015 20.4 0.2 0.42 9.1 0.1 2.7 2 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ORX54984.1 - 0.00047 18.9 10.8 0.018 13.7 0.2 5.5 4 2 3 7 7 7 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX54984.1 - 0.0015 17.6 0.2 0.52 9.2 0.0 3.7 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1513 PF07433.11 ORX54984.1 - 0.0019 17.4 0.0 0.14 11.2 0.0 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF1513) HisG PF01634.18 ORX54985.1 - 2.3e-52 177.2 0.2 3.3e-52 176.7 0.2 1.3 1 0 0 1 1 1 1 ATP phosphoribosyltransferase Mito_carr PF00153.27 ORX54985.1 - 2.8e-50 168.2 0.7 3e-17 62.3 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein HisG_C PF08029.11 ORX54985.1 - 1.7e-24 85.7 0.0 3.9e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 ORX54985.1 - 4e-05 23.7 0.1 7.8e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 NMT1/THI5 like Pox_T4_C PF04490.12 ORX54985.1 - 0.18 12.0 0.1 0.31 11.2 0.1 1.3 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus GPI-anchored PF10342.9 ORX54986.1 - 7.9e-11 42.6 0.0 1.5e-10 41.7 0.0 1.5 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DPBB_1 PF03330.18 ORX54987.1 - 1.2e-07 31.9 0.1 1.5e-07 31.6 0.1 1.4 1 1 0 1 1 1 1 Lytic transglycolase PAS PF00989.25 ORX54988.1 - 0.001 19.0 0.0 0.0019 18.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 ORX54988.1 - 0.0074 16.4 7.2 0.0074 16.4 7.2 1.7 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Med13_C PF06333.12 ORX54988.1 - 2.6 7.2 16.2 4.1 6.6 16.2 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Pkinase PF00069.25 ORX54989.1 - 1.3e-53 182.0 0.1 2.1e-53 181.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX54989.1 - 3.7e-21 75.6 0.0 6.7e-21 74.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX54989.1 - 0.007 15.7 0.2 0.015 14.7 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Flavin_Reduct PF01613.18 ORX54989.1 - 0.019 15.0 0.0 0.035 14.1 0.0 1.4 1 0 0 1 1 1 0 Flavin reductase like domain RIO1 PF01163.22 ORX54989.1 - 0.033 13.8 0.2 0.14 11.7 0.1 2.0 2 0 0 2 2 2 0 RIO1 family FAA_hydrolase_N PF09298.11 ORX54989.1 - 0.12 12.5 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal PDDEXK_7 PF04411.12 ORX54989.1 - 0.13 12.3 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily ABC_tran PF00005.27 ORX54990.1 - 1.3e-25 90.5 0.0 2e-25 89.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX54990.1 - 2.6e-08 34.1 0.1 0.00015 21.7 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX54990.1 - 4.8e-05 22.9 0.0 0.00043 19.8 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX54990.1 - 0.0002 21.8 0.0 0.00053 20.4 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ORX54990.1 - 0.00079 19.1 0.0 0.0013 18.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_30 PF13604.6 ORX54990.1 - 0.0008 19.2 0.0 0.0033 17.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX54990.1 - 0.0011 19.2 0.0 0.002 18.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 ORX54990.1 - 0.0017 18.3 0.1 0.025 14.5 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_23 PF13476.6 ORX54990.1 - 0.0024 18.4 0.0 0.004 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX54990.1 - 0.003 17.0 0.0 0.071 12.5 0.0 2.2 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ORX54990.1 - 0.0031 17.1 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ORX54990.1 - 0.0063 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_33 PF13671.6 ORX54990.1 - 0.016 15.3 0.2 0.046 13.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX54990.1 - 0.017 15.7 0.0 0.027 15.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX54990.1 - 0.017 15.0 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 ORX54990.1 - 0.033 14.4 0.1 0.94 9.8 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit T2SSE PF00437.20 ORX54990.1 - 0.038 13.1 0.0 0.062 12.3 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 ORX54990.1 - 0.045 13.8 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_ATPase PF09818.9 ORX54990.1 - 0.05 12.4 0.0 5.1 5.8 0.0 2.1 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DEAD PF00270.29 ORX54990.1 - 0.077 12.8 0.0 0.13 12.0 0.0 1.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase cobW PF02492.19 ORX54990.1 - 0.091 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA PF00004.29 ORX54990.1 - 0.093 13.2 0.0 0.67 10.4 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX54990.1 - 0.11 12.5 0.0 0.26 11.3 0.0 1.6 2 0 0 2 2 1 0 AAA domain AAA_5 PF07728.14 ORX54990.1 - 0.12 12.4 0.1 0.71 9.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ORX54990.1 - 0.12 12.6 0.1 0.27 11.4 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_27 PF13514.6 ORX54990.1 - 0.13 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ORX54990.1 - 0.14 12.5 0.0 0.75 10.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ORX54990.1 - 0.16 11.6 0.0 1.6 8.4 0.0 1.9 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase zf-C2H2 PF00096.26 ORX54991.1 - 9.9e-10 38.3 13.6 6.7e-06 26.3 4.5 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX54991.1 - 1.9e-08 34.4 11.1 0.00035 21.2 3.0 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX54991.1 - 4.2e-08 33.3 2.0 4.2e-08 33.3 2.0 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_11 PF16622.5 ORX54991.1 - 3.6e-05 23.4 7.0 0.0073 16.0 0.3 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX54991.1 - 0.00021 21.2 6.4 0.11 12.5 0.6 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX54991.1 - 0.00025 21.3 6.2 0.0028 18.0 0.9 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX54991.1 - 0.00074 19.7 4.0 0.54 10.6 0.1 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX54991.1 - 0.0025 17.5 12.1 0.044 13.6 7.0 2.6 2 1 0 2 2 2 2 C2H2-type zinc-finger domain zf-C2HC_2 PF13913.6 ORX54991.1 - 0.0053 16.6 11.0 0.014 15.3 2.2 2.5 2 1 0 2 2 2 2 zinc-finger of a C2HC-type zf-met PF12874.7 ORX54991.1 - 0.022 15.1 5.6 0.44 11.0 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf_ZIC PF18366.1 ORX54991.1 - 0.047 13.8 1.4 1.4 9.1 0.2 2.1 1 1 1 2 2 2 0 Zic proteins zinc finger domain zf-C2HE PF16278.5 ORX54991.1 - 0.14 12.6 7.1 1.1 9.8 1.0 2.1 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-LYAR PF08790.11 ORX54991.1 - 0.2 11.6 3.8 4.8 7.2 0.1 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf_C2H2_ZHX PF18387.1 ORX54991.1 - 0.48 10.1 5.7 3.5 7.3 0.5 2.1 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Spt46 PF17734.1 ORX54991.1 - 1.4 8.7 6.3 2 8.2 0.4 2.2 1 1 1 2 2 2 0 Spermatogenesis-associated protein 46 DUF629 PF04780.12 ORX54991.1 - 1.5 7.3 6.5 0.55 8.7 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 ORX54993.1 - 0.0033 17.8 6.9 0.0052 17.2 1.2 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX54993.1 - 0.045 14.6 0.8 0.045 14.6 0.8 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX54993.1 - 0.41 10.7 0.2 0.41 10.7 0.2 2.2 3 0 0 3 3 3 0 C2H2-type zinc finger WD40 PF00400.32 ORX54995.1 - 4.1e-06 27.4 8.4 0.13 13.2 0.0 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat Zds_C PF08632.10 ORX54996.1 - 6.2e-13 48.3 0.3 6.2e-13 48.3 0.3 1.6 2 0 0 2 2 2 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term Metallophos PF00149.28 ORX54997.1 - 1.4e-35 123.7 0.2 2.2e-35 123.0 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX54997.1 - 4.6e-17 62.2 0.3 1.2e-16 60.9 0.3 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Spidroin_MaSp PF11260.8 ORX54997.1 - 0.01 16.1 1.4 0.026 14.8 1.4 1.6 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 DUF2664 PF10867.8 ORX54997.1 - 0.099 13.1 0.1 0.32 11.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2664) Molybdopterin PF00384.22 ORX54998.1 - 5.9e-73 246.3 0.0 3.2e-72 243.8 0.0 1.9 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 ORX54998.1 - 8.3e-19 67.4 0.3 3.1e-18 65.6 0.2 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 ORX54998.1 - 1.5e-15 56.4 0.1 1.5e-15 56.4 0.1 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region NADH_dhqG_C PF09326.11 ORX54998.1 - 1.5e-13 51.1 0.0 3.7e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal Fer2 PF00111.27 ORX54998.1 - 7.7e-08 32.2 0.4 7.7e-08 32.2 0.4 2.0 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 ORX54998.1 - 6.8e-05 22.6 0.1 0.038 13.7 0.0 2.5 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain NAPRTase PF04095.16 ORX54999.1 - 5.1e-67 226.0 0.2 7.7e-67 225.4 0.2 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ORX54999.1 - 4.8e-36 123.9 0.8 8.5e-36 123.1 0.8 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain RhoGAP PF00620.27 ORX55000.1 - 4.7e-45 153.1 0.0 1.3e-44 151.7 0.0 1.8 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 ORX55000.1 - 2.2e-15 56.6 38.0 8.5e-10 38.7 11.6 3.4 3 0 0 3 3 3 2 LIM domain C1_1 PF00130.22 ORX55000.1 - 3.7e-06 26.7 3.5 3.7e-06 26.7 3.5 4.2 3 1 1 4 4 4 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Spore_II_R PF09551.10 ORX55000.1 - 0.4 11.2 5.7 1.3 9.5 5.7 1.9 1 0 0 1 1 1 0 Stage II sporulation protein R (spore_II_R) FapA PF03961.13 ORX55000.1 - 7.4 5.1 9.7 14 4.2 9.7 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A RGS PF00615.19 ORX55001.1 - 6.8e-17 61.8 0.0 9.9e-17 61.3 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain UDG PF03167.19 ORX55002.1 - 3.3e-25 88.9 0.0 6e-25 88.0 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily zf-C5HC2 PF02928.16 ORX55003.1 - 0.00021 21.6 1.8 0.41 11.1 0.1 2.3 2 0 0 2 2 2 2 C5HC2 zinc finger AsnA PF03590.15 ORX55004.1 - 0.054 13.2 0.0 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 Aspartate-ammonia ligase BTG PF07742.12 ORX55005.1 - 1.2e-30 105.7 0.0 1.6e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 BTG family CorA PF01544.18 ORX55006.1 - 5.2e-46 157.3 8.0 5.9e-46 157.1 8.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Dynactin_p22 PF07426.11 ORX55006.1 - 0.033 14.1 1.1 0.089 12.6 0.8 2.0 2 1 0 2 2 2 0 Dynactin subunit p22 Bac_RepA_C PF18008.1 ORX55006.1 - 0.072 13.4 0.2 0.65 10.4 0.0 2.4 2 0 0 2 2 2 0 Replication initiator protein A C-terminal domain CREPT PF16566.5 ORX55006.1 - 0.096 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour T4SS_TraI PF16932.5 ORX55006.1 - 0.1 11.7 0.2 0.26 10.4 0.1 1.7 2 0 0 2 2 2 0 Type IV secretory system, conjugal DNA-protein transfer BBP1_N PF15271.6 ORX55006.1 - 0.19 12.5 0.0 0.52 11.1 0.0 1.7 1 1 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein Thioredoxin PF00085.20 ORX55007.1 - 3.1e-47 158.8 0.0 9.1e-26 89.8 0.0 2.9 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 ORX55007.1 - 1.3e-14 54.5 0.0 7.2e-12 45.6 0.0 3.3 3 1 1 4 4 4 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ORX55007.1 - 3.7e-09 36.6 0.3 0.00026 21.1 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 ORX55007.1 - 6.2e-07 29.9 0.2 0.0022 18.4 0.0 2.8 2 1 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 ORX55007.1 - 0.00016 21.6 0.2 0.59 10.1 0.1 2.5 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 ORX55007.1 - 0.00022 21.5 0.1 2.4 8.6 0.0 4.2 4 1 1 5 5 5 1 Thioredoxin-like Thioredoxin_3 PF13192.6 ORX55007.1 - 0.0092 16.0 0.1 2.5 8.2 0.0 2.4 2 0 0 2 2 2 1 Thioredoxin domain Thioredoxin_9 PF14595.6 ORX55007.1 - 0.022 14.5 0.0 0.41 10.4 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin OST3_OST6 PF04756.13 ORX55007.1 - 0.023 14.1 0.0 0.2 11.0 0.1 2.1 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family UBX PF00789.20 ORX55007.1 - 0.042 14.0 0.0 0.18 12.1 0.0 2.0 1 0 0 1 1 1 0 UBX domain Thioredox_DsbH PF03190.15 ORX55007.1 - 0.098 12.6 0.5 0.79 9.7 0.0 2.7 3 1 0 3 3 3 0 Protein of unknown function, DUF255 Glutaredoxin PF00462.24 ORX55007.1 - 0.13 12.5 0.3 15 5.9 0.0 3.1 3 0 0 3 3 3 0 Glutaredoxin TraF PF13728.6 ORX55007.1 - 0.14 11.9 0.0 4.4 7.0 0.0 2.5 2 0 0 2 2 2 0 F plasmid transfer operon protein SMC_N PF02463.19 ORX55008.1 - 8.8e-73 244.4 0.0 3.7e-40 137.7 0.0 3.1 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX55008.1 - 3.8e-18 65.9 0.6 3.4e-17 62.8 0.1 2.6 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ORX55008.1 - 1.8e-11 44.4 8.7 2.4e-05 24.3 0.2 4.1 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX55008.1 - 1.2e-08 35.7 35.1 1.2e-08 35.7 35.1 6.8 2 2 1 3 3 3 1 AAA domain AAA_29 PF13555.6 ORX55008.1 - 3.2e-05 23.6 0.0 9.6e-05 22.0 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain FliJ PF02050.16 ORX55008.1 - 0.00059 20.1 13.4 0.00059 20.1 13.4 8.5 4 4 5 9 9 9 2 Flagellar FliJ protein ABC_tran PF00005.27 ORX55008.1 - 0.46 11.0 0.0 0.46 11.0 0.0 6.2 3 2 0 3 3 3 0 ABC transporter Pkinase_Tyr PF07714.17 ORX55009.1 - 3.2e-09 36.5 0.0 0.00084 18.7 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ORX55009.1 - 3.7e-09 36.3 0.0 0.00018 20.9 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Herpes_UL6 PF01763.16 ORX55009.1 - 0.1 11.1 0.0 0.16 10.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Homeobox_KN PF05920.11 ORX55009.1 - 2.8 7.9 6.3 5.3 7.0 1.9 2.6 2 0 0 2 2 2 0 Homeobox KN domain TPR_19 PF14559.6 ORX55010.1 - 0.094 13.2 0.2 0.12 12.9 0.2 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat F-box-like PF12937.7 ORX55011.1 - 2.8e-05 23.9 0.6 2.8e-05 23.9 0.6 3.2 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 ORX55011.1 - 7.8e-05 23.0 12.3 5.2 7.6 0.0 6.9 5 1 4 9 9 9 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX55011.1 - 0.0034 17.3 18.6 0.47 10.6 0.0 8.5 11 0 0 11 11 11 2 Leucine Rich repeat TruB_N PF01509.18 ORX55012.1 - 5.3e-45 153.4 0.0 7.1e-45 153.0 0.0 1.1 1 0 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 ORX55012.1 - 8.7e-07 29.0 0.1 1.7e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain DUF4381 PF14316.6 ORX55013.1 - 0.0038 17.5 0.1 0.0071 16.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF1929 PF09118.11 ORX55013.1 - 0.026 14.8 0.1 0.07 13.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) Saf_2TM PF18303.1 ORX55013.1 - 0.19 11.3 0.0 0.35 10.5 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Adeno_E3_CR2 PF02439.15 ORX55013.1 - 0.22 11.3 0.2 0.22 11.3 0.2 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 EXS PF03124.14 ORX55014.1 - 1.6e-74 251.2 21.2 2.1e-74 250.8 21.2 1.0 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ORX55015.1 - 3.4e-30 106.3 3.8 3.9e-30 106.1 3.8 1.1 1 0 0 1 1 1 1 SPX domain Cyclin_N PF00134.23 ORX55016.1 - 5.1e-18 65.0 0.0 6.6e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX55016.1 - 4.7e-07 30.3 0.0 5.6e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Cyclin DUF4491 PF14898.6 ORX55016.1 - 0.11 12.9 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4491) RNA_pol PF00940.19 ORX55017.1 - 3.1e-184 612.6 0.0 9.2e-184 611.1 0.0 1.7 2 0 0 2 2 2 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 ORX55017.1 - 8.6e-100 334.4 0.1 1.8e-99 333.4 0.1 1.6 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal PPR_2 PF13041.6 ORX55017.1 - 3.4e-08 33.5 0.1 3.7e-06 27.0 0.0 2.6 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ORX55017.1 - 0.0073 16.5 0.2 53 4.4 0.0 4.1 4 0 0 4 4 4 0 PPR repeat L27_2 PF09045.10 ORX55017.1 - 0.045 13.7 0.1 1.7 8.7 0.0 2.5 2 0 0 2 2 2 0 L27_2 ApoLp-III PF07464.11 ORX55017.1 - 0.055 13.6 1.0 0.19 11.8 1.0 1.9 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) PPR_1 PF12854.7 ORX55017.1 - 0.11 12.3 1.7 2.5 7.9 0.0 3.0 3 0 0 3 3 3 0 PPR repeat MSA-2c PF12238.8 ORX55017.1 - 2.2 8.3 5.6 3 7.8 1.7 2.5 2 0 0 2 2 2 0 Merozoite surface antigen 2c TPR_12 PF13424.6 ORX55018.1 - 0.00013 22.2 0.8 0.053 13.8 0.1 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX55018.1 - 0.0035 17.3 1.3 0.11 12.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX55018.1 - 0.037 13.8 1.4 0.63 10.0 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX55018.1 - 0.14 12.5 1.3 1.4 9.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX55018.1 - 0.15 12.2 0.5 3.7 7.8 0.1 3.0 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX55018.1 - 0.23 11.5 4.0 0.3 11.1 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-C2H2 PF00096.26 ORX55019.1 - 7.6e-25 85.9 28.1 2.3e-06 27.7 1.9 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX55019.1 - 3.6e-23 80.9 32.0 3.7e-08 33.4 1.4 5.8 6 0 0 6 6 6 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX55019.1 - 4.2e-14 52.0 25.6 0.0011 19.6 1.4 4.4 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX55019.1 - 5.6e-06 26.6 5.6 0.03 14.5 0.1 3.1 2 1 1 3 3 3 2 Aberrant zinc-finger FOXP-CC PF16159.5 ORX55019.1 - 6.5e-06 26.7 6.5 0.13 12.9 0.1 3.7 2 2 2 4 4 4 2 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX55019.1 - 1.9e-05 24.8 10.5 0.19 12.0 0.1 4.2 4 0 0 4 4 4 3 Zinc-finger double-stranded RNA-binding DUF4729 PF15866.5 ORX55019.1 - 0.0006 19.2 4.2 0.0014 18.0 0.0 2.5 2 1 0 2 2 2 1 Domain of unknown function (DUF4729) zf-TRAF PF02176.18 ORX55019.1 - 0.00071 20.2 12.1 0.0046 17.6 1.7 3.2 1 1 3 4 4 4 2 TRAF-type zinc finger zf-H2C2_5 PF13909.6 ORX55019.1 - 0.0011 18.6 20.8 0.25 11.1 0.3 4.7 4 1 0 4 4 4 2 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.6 ORX55019.1 - 0.0025 17.8 21.0 0.039 14.0 0.6 4.7 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX55019.1 - 0.0031 17.8 8.7 0.27 11.5 2.8 3.0 1 1 2 3 3 3 2 C2H2-type zinc ribbon Ogr_Delta PF04606.12 ORX55019.1 - 0.036 14.0 8.1 1.8 8.6 0.1 3.3 2 1 1 3 3 3 0 Ogr/Delta-like zinc finger zf-met PF12874.7 ORX55019.1 - 0.05 14.0 10.0 6.8 7.2 0.0 4.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf_ZIC PF18366.1 ORX55019.1 - 0.61 10.2 0.1 0.61 10.2 0.1 3.4 4 0 0 4 4 4 0 Zic proteins zinc finger domain KH_1 PF00013.29 ORX55021.1 - 4.5e-13 48.8 0.0 1.1e-07 31.6 0.0 2.2 2 0 0 2 2 2 2 KH domain Semialdhyde_dhC PF02774.18 ORX55022.1 - 6.3e-37 127.4 0.0 8.4e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 ORX55022.1 - 1.1e-31 109.8 0.0 1.8e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 ORX55022.1 - 0.0056 17.4 0.1 0.025 15.3 0.0 2.2 3 0 0 3 3 3 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase Asp PF00026.23 ORX55023.1 - 3.1e-30 105.7 0.0 3.7e-30 105.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX55023.1 - 1.4e-18 67.8 0.0 2.1e-09 37.9 0.0 2.4 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX55023.1 - 0.00065 20.3 0.0 0.0015 19.1 0.0 1.6 1 1 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX55023.1 - 0.011 16.3 0.0 0.022 15.3 0.0 1.5 1 1 0 1 1 1 0 gag-polyprotein putative aspartyl protease ECH_1 PF00378.20 ORX55025.1 - 1e-51 175.7 0.0 1.3e-51 175.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX55025.1 - 9.3e-29 101.0 0.1 1.2e-28 100.7 0.1 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase DUF3005 PF11448.8 ORX55025.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3005) Tcp11 PF05794.13 ORX55026.1 - 4.1e-51 174.5 0.1 5e-51 174.2 0.1 1.1 1 0 0 1 1 1 1 T-complex protein 11 Ribosomal_L15e PF00827.17 ORX55027.1 - 1.3e-77 259.9 2.0 1.5e-77 259.7 2.0 1.0 1 0 0 1 1 1 1 Ribosomal L15 Tim17 PF02466.19 ORX55028.1 - 7.4e-06 26.3 2.4 0.00051 20.4 0.0 2.8 2 1 1 3 3 3 2 Tim17/Tim22/Tim23/Pmp24 family ABC_tran_CTD PF16326.5 ORX55028.1 - 0.062 13.6 1.5 0.11 12.8 1.5 1.3 1 0 0 1 1 1 0 ABC transporter C-terminal domain Halogen_Hydrol PF10112.9 ORX55028.1 - 0.16 12.0 0.3 0.46 10.5 0.1 1.7 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ABC-3 PF00950.17 ORX55028.1 - 0.87 9.0 4.2 0.58 9.6 0.1 2.2 2 1 1 3 3 3 0 ABC 3 transport family ThrE PF06738.12 ORX55030.1 - 9.6e-28 97.2 25.6 1.1e-25 90.4 10.1 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX55030.1 - 1.5e-05 25.1 6.8 1.5e-05 25.1 6.8 2.2 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Zn_clus PF00172.18 ORX55031.1 - 6.1e-09 35.9 12.7 1.5e-08 34.6 12.7 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Importin_rep_4 PF18808.1 ORX55031.1 - 1.1 9.5 0.0 1.1 9.5 0.0 2.8 3 0 0 3 3 3 0 Importin repeat WAPL PF07814.13 ORX55032.1 - 0.029 13.2 1.9 0.042 12.6 0.2 1.8 1 1 0 2 2 2 0 Wings apart-like protein regulation of heterochromatin AIG1 PF04548.16 ORX55033.1 - 2e-10 40.4 0.0 4.6e-10 39.2 0.0 1.6 1 1 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ORX55033.1 - 9.9e-07 29.0 0.2 6.8e-05 23.0 0.0 2.4 3 0 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ORX55033.1 - 1.9e-06 27.9 0.0 2.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 ORX55033.1 - 2.8e-06 26.8 0.0 4.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Septin RsgA_GTPase PF03193.16 ORX55033.1 - 0.00054 19.9 0.4 0.003 17.5 0.4 2.0 1 1 0 1 1 1 1 RsgA GTPase IIGP PF05049.13 ORX55033.1 - 0.021 13.9 0.0 0.031 13.3 0.0 1.4 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) ABC_tran PF00005.27 ORX55033.1 - 0.044 14.3 0.4 0.27 11.8 0.2 2.0 1 1 1 2 2 2 0 ABC transporter CRAL_TRIO PF00650.20 ORX55033.1 - 0.049 13.4 0.0 0.077 12.7 0.0 1.2 1 0 0 1 1 1 0 CRAL/TRIO domain Abhydrolase_6 PF12697.7 ORX55033.1 - 0.068 13.8 0.4 0.13 12.8 0.3 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase family Roc PF08477.13 ORX55033.1 - 0.17 12.1 0.0 0.35 11.1 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Pep3_Vps18 PF05131.14 ORX55035.1 - 3.2e-44 150.4 3.4 2.7e-42 144.1 0.2 3.0 2 0 0 2 2 2 2 Pep3/Vps18/deep orange family Clathrin PF00637.20 ORX55035.1 - 1.1e-21 77.2 19.1 7.6e-13 48.6 0.6 4.5 2 2 2 4 4 4 3 Region in Clathrin and VPS Plasmod_MYXSPDY PF07981.11 ORX55035.1 - 0.094 12.7 0.3 0.36 10.9 0.1 2.1 2 0 0 2 2 2 0 Plasmodium repeat_MYXSPDY TPR_1 PF00515.28 ORX55035.1 - 2.2 8.2 4.1 5.3 7.0 0.1 3.4 4 1 1 5 5 5 0 Tetratricopeptide repeat YjeF_N PF03853.15 ORX55036.1 - 3.6e-28 98.6 0.1 6e-28 97.9 0.1 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus DFP PF04127.15 ORX55036.1 - 0.029 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein RasGEF_N PF00618.20 ORX55037.1 - 0.019 15.2 0.4 0.036 14.3 0.0 1.7 2 0 0 2 2 2 0 RasGEF N-terminal motif MLD PF11647.8 ORX55037.1 - 0.072 13.4 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Membrane Localization Domain UPRTase PF14681.6 ORX55039.1 - 2.2e-76 255.9 0.0 2.4e-76 255.8 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ORX55039.1 - 0.008 15.7 0.0 0.01 15.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain AMP-binding PF00501.28 ORX55041.1 - 1.7e-72 244.3 0.2 2.2e-72 244.0 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX55041.1 - 2.5e-15 57.2 0.2 5.3e-15 56.1 0.2 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Cpn60_TCP1 PF00118.24 ORX55042.1 - 3.4e-168 560.3 4.2 3.8e-168 560.1 4.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ribosomal_S3_C PF00189.20 ORX55043.1 - 7.2e-23 80.9 1.3 2e-22 79.5 0.8 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ORX55043.1 - 8e-12 44.8 0.1 1.4e-11 44.1 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 ORX55043.1 - 0.099 13.1 0.0 0.18 12.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 RINGv PF12906.7 ORX55045.1 - 1e-11 44.7 4.5 2.2e-11 43.7 4.5 1.6 1 0 0 1 1 1 1 RING-variant domain Baculo_11_kDa PF06143.11 ORX55045.1 - 0.013 15.1 1.8 0.026 14.1 0.5 2.2 2 0 0 2 2 2 0 Baculovirus 11 kDa family Bromodomain PF00439.25 ORX55046.1 - 1.9e-36 124.0 3.0 5.7e-18 64.8 0.6 2.7 2 0 0 2 2 2 2 Bromodomain Ank_2 PF12796.7 ORX55046.1 - 1.5e-11 44.7 0.1 2.9e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX55046.1 - 1e-09 38.4 0.6 2.3e-05 24.6 0.4 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 ORX55046.1 - 2.9e-09 36.4 0.1 0.0012 19.1 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX55046.1 - 5.1e-09 36.2 1.7 4.6e-06 26.8 0.1 3.7 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX55046.1 - 3.4e-06 27.5 1.2 1.4e-05 25.5 0.1 2.6 3 0 0 3 3 3 1 Ankyrin repeats (many copies) AT_hook PF02178.19 ORX55046.1 - 0.05 13.5 2.0 0.24 11.4 2.0 2.3 1 0 0 1 1 1 0 AT hook motif EF-hand_1 PF00036.32 ORX55047.1 - 3e-05 23.3 0.1 0.00011 21.5 0.1 2.1 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ORX55047.1 - 7.7e-05 23.1 0.1 0.00084 19.7 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX55047.1 - 9.8e-05 22.0 0.2 0.00053 19.7 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain F-box-like PF12937.7 ORX55047.1 - 0.00018 21.3 0.2 0.0054 16.6 0.1 2.5 2 0 0 2 2 2 1 F-box-like EF-hand_5 PF13202.6 ORX55047.1 - 0.00082 18.8 0.4 0.0021 17.5 0.4 1.7 1 0 0 1 1 1 1 EF hand EF_assoc_1 PF08355.12 ORX55047.1 - 0.0046 16.5 0.0 0.0075 15.8 0.0 1.3 1 0 0 1 1 1 1 EF hand associated TPR_19 PF14559.6 ORX55047.1 - 0.009 16.5 0.4 0.21 12.1 0.0 2.7 3 1 0 3 3 2 1 Tetratricopeptide repeat PCRF PF03462.18 ORX55047.1 - 0.036 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 PCRF domain TPR_16 PF13432.6 ORX55047.1 - 0.045 14.4 0.0 0.14 12.9 0.0 1.8 2 0 0 2 2 1 0 Tetratricopeptide repeat FPRL1_inhibitor PF16104.5 ORX55047.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein ANAPC3 PF12895.7 ORX55047.1 - 0.071 13.3 0.2 0.57 10.4 0.2 2.3 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 F-box PF00646.33 ORX55047.1 - 0.093 12.6 0.5 0.39 10.6 0.3 2.0 2 0 0 2 2 2 0 F-box domain AAA_23 PF13476.6 ORX55048.1 - 2.5e-16 60.8 0.0 2.8e-16 60.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ORX55048.1 - 7.5e-15 55.0 0.0 9.2e-15 54.7 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ORX55048.1 - 6.6e-07 29.4 0.0 6.9e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ORX55048.1 - 5.5e-05 22.8 0.0 0.00011 21.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX55048.1 - 9e-05 22.4 0.1 0.00011 22.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 ORX55048.1 - 0.00033 21.2 0.4 0.00045 20.8 0.4 1.3 1 1 0 1 1 1 1 ABC transporter AAA_27 PF13514.6 ORX55048.1 - 0.0016 18.1 0.0 0.0033 17.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ORX55048.1 - 0.022 15.2 0.1 0.037 14.5 0.1 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ORX55048.1 - 0.04 14.1 0.0 0.059 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX55048.1 - 0.043 13.4 0.0 0.056 13.0 0.0 1.3 1 1 0 1 1 1 0 AAA domain AAA_13 PF13166.6 ORX55048.1 - 0.044 12.4 0.3 0.12 11.0 0.1 1.7 1 1 1 2 2 2 0 AAA domain Tox-MPTase4 PF15640.6 ORX55048.1 - 0.067 13.1 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 4 SMC_N PF02463.19 ORX55049.1 - 9.8e-07 28.4 1.2 9.8e-07 28.4 1.2 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain NYD-SP28 PF14772.6 ORX55049.1 - 0.01 15.8 8.3 0.01 15.8 8.3 3.7 4 0 0 4 4 4 0 Sperm tail VASP_tetra PF08776.11 ORX55049.1 - 0.048 13.2 1.1 0.38 10.4 0.2 2.7 2 0 0 2 2 2 0 VASP tetramerisation domain WXG100 PF06013.12 ORX55049.1 - 0.21 11.9 16.2 0.58 10.4 0.0 4.2 3 1 1 4 4 4 0 Proteins of 100 residues with WXG CENP-F_leu_zip PF10473.9 ORX55049.1 - 0.25 11.4 30.6 0.062 13.3 2.6 3.9 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DASH_Dam1 PF08653.10 ORX55049.1 - 0.48 10.3 1.5 6.9 6.6 0.5 3.1 2 0 0 2 2 2 0 DASH complex subunit Dam1 Fez1 PF06818.15 ORX55049.1 - 1.4 9.3 31.2 0.099 13.1 14.1 2.7 1 1 1 2 2 2 0 Fez1 Gp-FAR-1 PF05823.12 ORX55049.1 - 2.2 8.6 9.8 0.78 10.1 0.4 3.1 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Laminin_II PF06009.12 ORX55049.1 - 6.8 6.7 19.1 11 6.0 3.5 3.6 2 2 1 3 3 3 0 Laminin Domain II Seryl_tRNA_N PF02403.22 ORX55049.1 - 8.9 6.6 26.5 0.076 13.2 5.7 3.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Scaffolding_pro PF11418.8 ORX55049.1 - 9.1 6.9 10.3 14 6.3 1.4 3.1 2 2 0 2 2 2 0 Phi29 scaffolding protein ERM PF00769.19 ORX55049.1 - 9.1 6.0 36.0 36 4.1 12.5 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family TPR_1 PF00515.28 ORX55050.1 - 7.8e-06 25.5 6.9 9.6e-05 22.0 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55050.1 - 0.00049 20.3 13.5 0.00058 20.1 0.8 4.3 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX55050.1 - 0.00075 19.4 0.1 0.00075 19.4 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX55050.1 - 0.0024 17.5 0.3 0.009 15.7 0.0 2.1 2 0 0 2 2 2 1 TPR repeat TOM20_plant PF06552.12 ORX55050.1 - 0.031 14.0 2.4 1.6 8.5 0.1 3.3 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 TPR_8 PF13181.6 ORX55050.1 - 0.035 14.3 5.7 0.082 13.2 0.0 3.8 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX55050.1 - 0.11 13.1 6.4 10 6.9 0.3 4.5 3 2 0 3 3 3 0 Tetratricopeptide repeat Tweety PF04906.13 ORX55050.1 - 0.23 10.1 1.7 0.39 9.3 0.6 1.8 1 1 1 2 2 2 0 Tweety MIT PF04212.18 ORX55050.1 - 0.28 11.3 0.1 0.28 11.3 0.1 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ORX55050.1 - 0.57 10.7 12.7 0.58 10.7 0.0 4.7 4 3 1 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX55050.1 - 0.95 10.5 0.0 0.95 10.5 0.0 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat Prok-TraM PF09228.10 ORX55050.1 - 1.4 9.4 9.0 0.86 10.0 1.9 2.6 1 1 1 2 2 2 0 Prokaryotic Transcriptional repressor TraM Las1 PF04031.13 ORX55051.1 - 3.3e-45 153.9 0.1 6.3e-45 153.0 0.1 1.5 1 0 0 1 1 1 1 Las1-like Lactamase_B PF00753.27 ORX55052.1 - 5.4e-15 55.9 1.3 1e-14 55.1 1.3 1.4 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX55052.1 - 7.6e-05 22.3 0.1 0.00023 20.8 0.1 1.7 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Rax2 PF12768.7 ORX55053.1 - 0.00088 18.8 0.0 0.0024 17.3 0.0 1.8 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Syndecan PF01034.20 ORX55053.1 - 0.11 12.4 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain IBR PF01485.21 ORX55054.1 - 1e-21 76.9 49.9 2e-11 43.9 3.0 4.5 3 1 1 4 4 4 4 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ORX55054.1 - 0.00079 19.3 9.7 0.00079 19.3 9.7 4.3 3 1 1 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX55054.1 - 0.00082 19.7 12.8 0.00082 19.7 12.8 4.1 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX55054.1 - 0.0087 15.9 9.5 0.0087 15.9 9.5 5.4 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) PRP21_like_P PF12230.8 ORX55056.1 - 6.4e-49 166.8 10.2 1e-48 166.1 10.2 1.3 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 ORX55056.1 - 2.1e-32 110.9 5.2 2.2e-18 66.0 0.5 2.5 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 ORX55056.1 - 8.1e-05 22.1 0.3 0.00021 20.8 0.3 1.8 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger Adaptin_binding PF10199.9 ORX55056.1 - 0.031 14.9 8.1 0.052 14.2 5.3 2.6 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 PSCyt3 PF07627.11 ORX55056.1 - 1.3 9.3 3.7 2 8.7 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Peptidase_S8 PF00082.22 ORX55057.1 - 2.2e-45 155.2 1.5 3e-45 154.8 1.5 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX55057.1 - 2.2e-11 43.6 0.1 7e-11 42.0 0.0 1.9 2 0 0 2 2 2 1 PA domain fn3_5 PF06280.12 ORX55057.1 - 8.3e-11 42.6 0.0 2.3e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Fn3-like domain FixG_C PF11614.8 ORX55057.1 - 0.018 15.2 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Hexapep PF00132.24 ORX55058.1 - 8.2e-10 38.0 15.0 6.7e-07 28.8 4.0 4.3 2 2 0 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ORX55058.1 - 8.5e-05 22.2 11.2 0.0012 18.5 2.9 3.4 4 0 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 ORX55058.1 - 0.0002 20.5 0.2 0.00031 19.8 0.2 1.2 1 0 0 1 1 1 1 L-fucokinase EBP PF05241.12 ORX55059.1 - 6.6e-60 201.6 12.8 7.9e-60 201.3 12.8 1.0 1 0 0 1 1 1 1 Emopamil binding protein RSN1_7TM PF02714.15 ORX55060.1 - 6.7e-68 229.0 36.1 1.3e-67 228.0 36.1 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ORX55060.1 - 4.3e-40 137.8 0.0 6.7e-40 137.2 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ORX55060.1 - 1.3e-25 90.0 2.0 1.3e-25 90.0 2.0 4.4 5 0 0 5 5 5 1 Late exocytosis, associated with Golgi transport MFS_1 PF07690.16 ORX55061.1 - 2.6e-47 161.5 42.8 5.5e-47 160.4 42.8 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX55061.1 - 7.2e-15 54.8 12.9 7.2e-15 54.8 12.9 2.6 1 1 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX55062.1 - 3.3e-49 167.7 40.6 3.3e-49 167.7 40.6 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX55062.1 - 7.7e-17 61.3 14.9 7.7e-17 61.3 14.9 2.6 1 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 ORX55062.1 - 7.7e-12 44.4 14.0 7.7e-12 44.4 14.0 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Bacteriocin_IIc PF10439.9 ORX55062.1 - 9.1 6.5 11.1 17 5.6 6.8 3.0 2 0 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide DUF3716 PF12511.8 ORX55063.1 - 0.13 12.3 3.0 0.64 10.1 2.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3716) Pkinase PF00069.25 ORX55067.1 - 5.7e-50 170.1 0.0 7.1e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX55067.1 - 7.9e-29 100.7 0.0 9.4e-29 100.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 ORX55067.1 - 0.001 18.1 0.0 0.0019 17.3 0.0 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 ORX55067.1 - 0.0059 15.9 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX55067.1 - 0.013 15.4 0.0 0.056 13.4 0.0 1.8 1 1 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX55067.1 - 0.044 12.7 0.0 0.097 11.6 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 ORX55067.1 - 0.071 12.7 0.0 0.75 9.4 0.1 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Hist_deacetyl PF00850.19 ORX55068.1 - 1.3e-83 281.0 0.0 2e-83 280.4 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain zf-C2H2_4 PF13894.6 ORX55069.1 - 0.028 15.2 0.0 0.077 13.9 0.0 1.8 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX55069.1 - 0.061 13.8 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-RRPl_C4 PF17026.5 ORX55070.1 - 0.0077 16.3 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Putative ribonucleoprotein zinc-finger pf C4 type Rtf2 PF04641.12 ORX55070.1 - 0.02 14.3 7.1 0.025 13.9 7.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger MID_MedPIWI PF18296.1 ORX55070.1 - 0.037 13.8 0.2 0.037 13.8 0.2 1.8 1 1 1 2 2 2 0 MID domain of medPIWI Sec62 PF03839.16 ORX55070.1 - 0.29 10.6 5.5 0.34 10.4 5.5 1.3 1 1 0 1 1 1 0 Translocation protein Sec62 DUF3682 PF12446.8 ORX55070.1 - 2.9 8.4 10.8 1 9.8 6.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) zf-C2H2 PF00096.26 ORX55071.1 - 1.2e-08 34.9 12.8 1.9e-05 24.8 1.8 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX55071.1 - 2.7e-07 30.8 10.1 0.00011 22.7 1.6 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX55071.1 - 0.0001 22.8 8.4 0.0094 16.6 0.2 3.2 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX55071.1 - 0.00034 20.8 0.3 0.00034 20.8 0.3 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ORX55071.1 - 0.0014 18.9 2.2 0.0021 18.3 2.2 1.3 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 ORX55071.1 - 0.0017 18.7 13.8 0.0023 18.3 3.7 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX55071.1 - 0.01 15.8 0.4 0.01 15.8 0.4 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf_ZIC PF18366.1 ORX55071.1 - 0.21 11.7 2.5 4.7 7.4 0.0 3.3 3 0 0 3 3 3 0 Zic proteins zinc finger domain zf_C2H2_ZHX PF18387.1 ORX55071.1 - 2.1 8.1 7.7 2.2 8.0 0.1 3.2 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Adaptin_N PF01602.20 ORX55072.1 - 8.9e-146 486.5 5.5 1e-145 486.3 5.5 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX55072.1 - 1.5e-61 207.1 8.7 4.9e-61 205.5 0.9 3.3 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX55072.1 - 4.3e-19 68.7 0.1 3.4e-08 33.8 0.0 5.6 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.22 ORX55072.1 - 2.8e-11 42.7 7.2 0.00054 20.0 0.0 6.3 7 0 0 7 7 7 2 HEAT repeat Cnd3 PF12719.7 ORX55072.1 - 5e-05 22.6 1.8 0.0069 15.6 0.1 2.7 3 0 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain CLASP_N PF12348.8 ORX55072.1 - 0.00083 19.0 0.1 0.014 15.0 0.0 2.7 2 1 0 2 2 2 1 CLASP N terminal Arm PF00514.23 ORX55072.1 - 0.0015 18.5 0.4 1.2 9.3 0.0 4.3 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX55072.1 - 0.0035 17.8 0.1 0.61 10.7 0.0 4.3 4 1 1 5 5 4 1 HEAT-like repeat UNC45-central PF11701.8 ORX55072.1 - 0.0071 16.3 0.7 1.6 8.7 0.0 3.1 2 1 0 2 2 2 1 Myosin-binding striated muscle assembly central Atx10homo_assoc PF09759.9 ORX55072.1 - 0.0078 16.2 0.1 2 8.5 0.0 3.3 2 1 0 3 3 3 1 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 ORX55072.1 - 0.0079 16.4 2.4 3 8.1 0.0 4.4 2 2 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm_2 PF04826.13 ORX55072.1 - 0.03 13.8 1.2 0.28 10.6 0.2 2.6 2 0 0 2 2 2 0 Armadillo-like DUF5578 PF17741.1 ORX55072.1 - 0.45 9.9 3.4 12 5.2 0.0 3.6 3 2 0 3 3 3 0 Family of unknown function (DUF5578) Hexokinase_2 PF03727.16 ORX55073.1 - 4.1e-63 213.0 0.0 5.2e-63 212.7 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX55073.1 - 4.4e-49 167.1 0.0 6.4e-49 166.6 0.0 1.2 1 0 0 1 1 1 1 Hexokinase NTF2 PF02136.20 ORX55074.1 - 8.2e-31 107.1 0.1 1.8e-30 105.9 0.1 1.6 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 ORX55074.1 - 9.1e-10 38.2 0.6 2.3e-09 36.9 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ORX55074.1 - 0.0015 18.5 0.0 0.0015 18.5 0.0 2.3 2 0 0 2 2 1 1 RNA binding motif DUF4518 PF15008.6 ORX55074.1 - 0.02 14.1 8.9 0.32 10.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) Nup35_RRM_2 PF14605.6 ORX55074.1 - 0.027 14.5 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif IBP39 PF11422.8 ORX55074.1 - 0.031 14.0 1.7 0.063 13.0 1.7 1.4 1 0 0 1 1 1 0 Initiator binding protein 39 kDa DUF2367 PF10164.9 ORX55074.1 - 0.034 14.6 2.3 0.034 14.6 2.3 2.9 2 1 0 2 2 1 0 Uncharacterized conserved protein (DUF2367) RRM_occluded PF16842.5 ORX55074.1 - 0.044 13.6 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif UPF0560 PF10577.9 ORX55074.1 - 0.44 9.0 13.9 0.78 8.2 13.9 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 eIF3_subunit PF08597.10 ORX55074.1 - 2.8 7.8 22.7 0.13 12.1 10.8 2.4 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Pannexin_like PF12534.8 ORX55074.1 - 7.4 5.6 9.7 14 4.7 9.7 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ribosomal_L37ae PF01780.19 ORX55076.1 - 2.9e-26 91.4 4.8 3.1e-26 91.2 4.8 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family zf-RING_13 PF17977.1 ORX55076.1 - 0.00025 21.1 2.4 0.00028 20.9 2.4 1.1 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Zn_Tnp_IS1595 PF12760.7 ORX55076.1 - 0.0043 17.0 2.5 0.0075 16.2 2.5 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-FCS PF06467.14 ORX55076.1 - 0.017 15.1 2.2 0.28 11.1 0.3 2.1 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-BED PF02892.15 ORX55076.1 - 0.022 14.8 4.9 0.54 10.3 0.3 2.1 1 1 1 2 2 2 0 BED zinc finger DUF2175 PF09943.9 ORX55076.1 - 0.041 14.2 0.5 8.8 6.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) A2L_zn_ribbon PF08792.10 ORX55076.1 - 0.12 12.2 4.2 2.2 8.1 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF1451 PF07295.11 ORX55076.1 - 0.13 12.2 1.0 0.21 11.6 1.0 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-H2C2_2 PF13465.6 ORX55076.1 - 0.74 10.3 6.4 1.2 9.7 1.4 2.1 1 1 1 2 2 2 0 Zinc-finger double domain HalOD2 PF18547.1 ORX55076.1 - 0.95 9.4 6.2 0.5 10.3 1.1 2.2 1 1 1 2 2 2 0 Halobacterial output domain 2 Kelch_6 PF13964.6 ORX55077.1 - 1.2e-16 60.3 0.0 0.0003 21.0 0.0 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ORX55077.1 - 2.6e-15 56.2 2.6 9.2e-05 22.4 0.1 3.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX55077.1 - 2.5e-13 49.7 0.2 0.00021 21.2 0.0 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 ORX55077.1 - 1.5e-10 41.1 1.1 0.028 14.7 0.1 4.7 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX55077.1 - 8e-10 38.3 0.1 0.14 12.2 0.0 4.1 4 0 0 4 4 4 3 Kelch motif BTB PF00651.31 ORX55077.1 - 2.3e-08 34.2 0.0 4.9e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 BTB/POZ domain Kelch_1 PF01344.25 ORX55077.1 - 3.5e-06 26.5 0.0 0.004 16.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif BACK PF07707.15 ORX55077.1 - 0.0003 20.8 0.0 0.00098 19.2 0.0 1.9 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF2673 PF10880.8 ORX55077.1 - 0.51 10.5 7.0 1.9 8.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2673) Ribosomal_L29 PF00831.23 ORX55078.1 - 1e-18 67.0 3.7 1e-18 67.0 3.7 2.3 1 1 1 2 2 2 1 Ribosomal L29 protein DUF4208 PF13907.6 ORX55078.1 - 0.047 14.1 4.1 0.38 11.2 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) Vps54_N PF10475.9 ORX55078.1 - 0.3 10.3 4.6 0.36 10.1 4.6 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex Prefoldin PF02996.17 ORX55078.1 - 0.46 10.4 7.4 0.36 10.8 1.4 2.7 1 1 2 3 3 3 0 Prefoldin subunit HMG_box PF00505.19 ORX55079.1 - 1.8e-15 57.1 0.1 3.6e-15 56.1 0.1 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX55079.1 - 4.8e-05 23.9 0.2 0.00031 21.3 0.1 2.2 1 1 1 2 2 2 1 HMG-box domain HSP90 PF00183.18 ORX55080.1 - 1.6e-234 779.6 29.6 2e-234 779.3 29.6 1.0 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ORX55080.1 - 2e-14 54.0 0.7 3.8e-14 53.1 0.1 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX55080.1 - 3.8e-10 39.7 0.1 1.4e-09 37.9 0.1 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Glyco_hydro_18 PF00704.28 ORX55082.1 - 6.5e-87 292.2 0.6 7.5e-87 292.0 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 APG5 PF04106.12 ORX55083.1 - 2.2e-55 187.8 0.3 3.6e-55 187.0 0.3 1.4 1 1 0 1 1 1 1 Autophagy protein Apg5 PUF PF00806.19 ORX55084.1 - 1.1e-66 217.0 16.5 4.1e-08 32.5 0.1 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat TBPIP PF07106.13 ORX55084.1 - 2.9 7.9 5.9 12 6.0 0.0 4.1 6 0 0 6 6 6 0 TBPIP/Hop2 winged helix domain NDT80_PhoG PF05224.12 ORX55085.1 - 1.4e-39 136.3 0.0 3.7e-39 134.9 0.0 1.8 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family TRAUB PF08164.12 ORX55086.1 - 2.6e-30 104.8 0.4 2.6e-30 104.8 0.4 1.4 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal Phage_tail_S PF05069.13 ORX55086.1 - 0.088 12.7 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 Phage virion morphogenesis family AATF-Che1 PF13339.6 ORX55087.1 - 5.2e-33 114.7 1.3 5.2e-33 114.7 1.3 2.6 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor NTF2 PF02136.20 ORX55087.1 - 0.12 13.0 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain DUF473 PF04322.12 ORX55087.1 - 0.19 11.6 0.9 0.76 9.6 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF473) Prominin PF05478.11 ORX55087.1 - 5.1 4.9 6.4 7 4.5 6.4 1.2 1 0 0 1 1 1 0 Prominin 4HB_MCP_1 PF12729.7 ORX55087.1 - 9.6 5.7 9.7 1.3 8.6 4.1 2.1 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction NUDE_C PF04880.13 ORX55090.1 - 4.5 7.7 5.9 2.9 8.3 0.8 2.0 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region DDE_3 PF13358.6 ORX55091.1 - 0.0083 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 DDE superfamily endonuclease Stomoxyn PF11585.8 ORX55092.1 - 0.11 12.5 1.8 0.15 12.1 1.8 1.3 1 1 0 1 1 1 0 Insect antimicrobial peptide, stomoxyn Tmemb_14 PF03647.13 ORX55096.1 - 1.4e-24 86.6 10.7 1.6e-24 86.5 10.7 1.0 1 0 0 1 1 1 1 Transmembrane proteins 14C YvrJ PF12841.7 ORX55096.1 - 0.022 14.3 0.1 0.032 13.7 0.1 1.3 1 0 0 1 1 1 0 YvrJ protein family START PF01852.19 ORX55098.1 - 2.9e-11 43.2 0.0 5.2e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 START domain RabGAP-TBC PF00566.18 ORX55099.1 - 7.8e-20 71.4 0.6 7.8e-20 71.4 0.6 2.8 4 0 0 4 4 4 1 Rab-GTPase-TBC domain MbeD_MobD PF04899.12 ORX55099.1 - 1.2 9.3 14.1 0.81 9.9 2.1 3.2 2 0 0 2 2 2 0 MbeD/MobD like APG6_N PF17675.1 ORX55099.1 - 5 7.7 38.8 0.077 13.5 5.6 4.1 3 1 1 4 4 4 0 Apg6 coiled-coil region Velvet PF11754.8 ORX55100.1 - 1.6e-47 162.6 1.9 1.2e-31 110.6 0.3 2.1 1 1 1 2 2 2 2 Velvet factor Velvet PF11754.8 ORX55101.1 - 1.4e-74 251.2 2.0 2.2e-44 152.3 0.1 2.0 1 1 1 2 2 2 2 Velvet factor Fanconi_A PF03511.14 ORX55101.1 - 0.12 12.3 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein MRG PF05712.13 ORX55102.1 - 7.1e-47 159.3 2.7 1.1e-46 158.7 2.7 1.2 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 ORX55102.1 - 2.5e-12 46.5 0.5 5e-12 45.5 0.5 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Chromo PF00385.24 ORX55102.1 - 0.00087 19.1 1.3 0.0022 17.9 0.4 2.1 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain ArfGap PF01412.18 ORX55104.1 - 2e-23 82.7 0.0 2.6e-23 82.3 0.0 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf TF_Zn_Ribbon PF08271.12 ORX55104.1 - 0.072 12.6 0.4 0.14 11.7 0.4 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding Zn_Tnp_IS1595 PF12760.7 ORX55104.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain LIDHydrolase PF10230.9 ORX55105.1 - 5.3e-61 206.5 0.0 6.2e-61 206.3 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 ORX55105.1 - 1e-08 34.8 0.1 1.3e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX55105.1 - 3.7e-06 26.8 0.0 0.0011 18.6 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX55105.1 - 0.00011 22.9 0.6 0.00022 21.9 0.6 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 ORX55105.1 - 0.0003 21.0 0.0 0.00074 19.7 0.0 1.8 1 1 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 ORX55105.1 - 0.054 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein DUF900 PF05990.12 ORX55105.1 - 0.058 12.9 0.0 0.25 10.8 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) DUF3530 PF12048.8 ORX55105.1 - 0.073 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) DUF2920 PF11144.8 ORX55105.1 - 0.11 11.7 0.0 1.4 8.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2920) Abhydrolase_5 PF12695.7 ORX55105.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family VTC PF09359.10 ORX55106.1 - 1.8e-81 273.5 0.0 4.6e-81 272.2 0.0 1.7 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 ORX55106.1 - 2e-11 44.2 5.8 2e-11 44.2 5.8 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) SPX PF03105.19 ORX55106.1 - 0.015 15.2 26.9 0.11 12.3 2.8 4.0 2 1 2 4 4 4 0 SPX domain Proteasom_PSMB PF10508.9 ORX55107.1 - 2.6e-40 138.4 0.0 3.1e-40 138.1 0.0 1.0 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.20 ORX55107.1 - 0.0024 16.5 0.1 0.0094 14.6 0.1 2.3 1 1 0 1 1 1 1 Adaptin N terminal region RasGEF_N_2 PF14663.6 ORX55107.1 - 0.02 15.3 0.1 0.41 11.1 0.0 2.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT PF02985.22 ORX55107.1 - 0.027 14.7 0.2 37 4.9 0.0 4.7 4 0 0 4 4 4 0 HEAT repeat Peptidase_C1_2 PF03051.15 ORX55108.1 - 1.5e-144 482.0 1.0 1.7e-144 481.9 1.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 ORX55108.1 - 0.011 15.8 0.0 2 8.4 0.0 2.5 3 0 0 3 3 3 0 Papain family cysteine protease PCI PF01399.27 ORX55109.1 - 4.1e-15 56.2 0.2 1.4e-14 54.5 0.2 2.0 1 0 0 1 1 1 1 PCI domain RPN7 PF10602.9 ORX55109.1 - 0.00076 19.2 0.0 0.0015 18.2 0.0 1.4 1 0 0 1 1 1 1 26S proteasome subunit RPN7 CSN4_RPN5_eIF3a PF18420.1 ORX55109.1 - 0.0017 18.5 0.8 0.004 17.3 0.1 2.0 2 0 0 2 2 2 1 CSN4/RPN5/eIF3a helix turn helix domain Mitofilin PF09731.9 ORX55110.1 - 5.8e-74 250.1 34.4 9.5e-64 216.3 29.0 2.4 1 1 1 2 2 2 2 Mitochondrial inner membrane protein DUF1467 PF07330.12 ORX55110.1 - 0.0068 16.3 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1467) ASL_C PF08328.11 ORX55110.1 - 0.023 14.8 2.3 0.082 13.0 2.3 2.0 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal TBCC_N PF16752.5 ORX55110.1 - 0.05 14.1 0.0 0.05 14.1 0.0 3.8 3 1 0 3 3 3 0 Tubulin-specific chaperone C N-terminal domain NPV_P10 PF05531.12 ORX55110.1 - 0.28 11.7 3.2 14 6.2 0.0 3.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Oberon_cc PF16312.5 ORX55110.1 - 0.32 10.9 9.5 0.12 12.3 6.2 2.0 2 0 0 2 2 2 0 Coiled-coil region of Oberon Histidinol_dh PF00815.20 ORX55111.1 - 6.7e-165 549.0 1.1 6.7e-165 549.0 1.1 1.5 2 0 0 2 2 2 1 Histidinol dehydrogenase PRA-CH PF01502.18 ORX55111.1 - 5.3e-24 83.8 0.3 1.1e-23 82.8 0.3 1.6 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 ORX55111.1 - 7.8e-17 61.5 0.4 6.9e-16 58.5 0.1 2.4 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 ORX55111.1 - 0.068 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain Tmemb_170 PF10190.9 ORX55112.1 - 8.4e-10 39.0 10.6 1.1e-09 38.6 10.6 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 DUF2417 PF10329.9 ORX55113.1 - 0.014 14.8 8.1 0.023 14.1 8.1 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) Fungal_trans_2 PF11951.8 ORX55113.1 - 0.088 11.6 0.1 0.14 11.0 0.1 1.3 1 0 0 1 1 1 0 Fungal specific transcription factor domain INTS5_N PF14837.6 ORX55113.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.3 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus MFS_MOT1 PF16983.5 ORX55113.1 - 0.9 10.0 7.5 0.39 11.1 0.3 2.9 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily GUN4_N PF16416.5 ORX55114.1 - 0.061 13.3 0.6 0.1 12.6 0.6 1.4 1 0 0 1 1 1 0 ARM-like repeat domain, GUN4-N terminal EF-hand_7 PF13499.6 ORX55115.1 - 1.8e-06 28.3 0.0 2.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX55115.1 - 0.0021 17.9 0.1 0.036 14.0 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain EF_assoc_1 PF08355.12 ORX55115.1 - 0.0024 17.4 0.1 0.0039 16.7 0.1 1.3 1 0 0 1 1 1 1 EF hand associated EF-hand_1 PF00036.32 ORX55115.1 - 0.0078 15.7 0.0 0.02 14.4 0.0 1.7 1 0 0 1 1 1 1 EF hand Aminotran_1_2 PF00155.21 ORX55116.1 - 4.3e-63 213.7 0.0 5e-63 213.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX55116.1 - 0.00022 20.6 0.0 0.00033 20.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ORX55116.1 - 0.00032 20.1 0.0 0.0006 19.2 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ORX55116.1 - 0.00042 19.4 0.0 0.004 16.2 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ORX55116.1 - 0.00094 17.8 0.0 0.0019 16.8 0.0 1.4 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme MMS1_N PF10433.9 ORX55119.1 - 1.1e-153 512.5 0.0 1.8e-153 511.7 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX55119.1 - 7.7e-92 308.0 0.0 3.2e-91 306.0 0.0 1.9 2 0 0 2 2 2 1 CPSF A subunit region DIM PF08194.12 ORX55120.1 - 0.19 12.0 0.5 0.19 12.0 0.5 2.1 2 0 0 2 2 2 0 DIM protein Apt1 PF10351.9 ORX55120.1 - 6.3 5.5 7.4 7.4 5.3 7.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CwfJ_C_1 PF04677.15 ORX55121.1 - 2.2e-25 88.9 0.0 5.9e-25 87.5 0.0 1.7 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 zf-CCHC_2 PF13696.6 ORX55121.1 - 5.7e-22 77.2 14.6 1.6e-11 43.8 4.0 2.6 2 0 0 2 2 2 2 Zinc knuckle CwfJ_C_2 PF04676.14 ORX55121.1 - 1.6e-14 54.6 0.2 3.5e-14 53.5 0.2 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 zf-CCHC PF00098.23 ORX55121.1 - 6.3e-11 41.8 6.8 4.7e-05 23.3 0.7 2.8 2 0 0 2 2 2 2 Zinc knuckle DUF3829 PF12889.7 ORX55121.1 - 0.033 13.7 0.9 0.049 13.1 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DUF2152 PF10222.9 ORX55121.1 - 0.074 11.4 0.0 0.098 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2152) zf-CCHC_3 PF13917.6 ORX55121.1 - 0.14 12.1 1.6 9.4 6.3 0.1 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ORX55121.1 - 0.42 10.4 4.7 7.1 6.5 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-C2H2_10 PF16588.5 ORX55121.1 - 2.8 7.8 4.1 29 4.5 0.2 2.4 2 0 0 2 2 2 0 C2H2 zinc-finger Hydrolase_6 PF13344.6 ORX55122.1 - 5.7e-27 93.8 0.0 1.6e-26 92.3 0.0 1.8 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX55122.1 - 7.1e-15 54.8 0.0 1.6e-14 53.7 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX55122.1 - 6.6e-05 23.3 0.0 0.00035 20.9 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX55122.1 - 0.0025 17.9 0.0 0.11 12.5 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Atg14 PF10186.9 ORX55124.1 - 1e-33 116.8 23.6 9.2e-33 113.7 23.6 2.7 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Cluap1 PF10234.9 ORX55124.1 - 0.4 10.0 10.3 0.65 9.3 10.3 1.4 1 0 0 1 1 1 0 Clusterin-associated protein-1 HWE_HK PF07536.14 ORX55124.1 - 2.8 8.7 9.0 3.1 8.6 3.6 2.5 1 1 0 2 2 2 0 HWE histidine kinase VPS38 PF17649.1 ORX55124.1 - 7.3 5.4 11.1 0.31 9.9 4.5 1.9 2 1 0 2 2 2 0 Vacuolar protein sorting 38 Fungal_trans PF04082.18 ORX55125.1 - 2.5e-25 89.0 0.0 4.7e-25 88.1 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX55125.1 - 1.5e-09 37.8 15.2 3e-09 36.8 15.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RRM_2 PF04059.12 ORX55126.1 - 2.8e-47 158.8 0.0 3.4e-47 158.6 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif 2 RRM_1 PF00076.22 ORX55126.1 - 0.0046 16.7 0.0 0.0098 15.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ORX55126.1 - 0.055 13.7 0.0 0.1 12.8 0.0 1.5 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Smg4_UPF3 PF03467.15 ORX55126.1 - 0.059 13.4 0.0 0.066 13.2 0.0 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family BRAP2 PF07576.12 ORX55126.1 - 0.082 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 BRCA1-associated protein 2 Topo_C_assoc PF14370.6 ORX55126.1 - 0.12 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal topoisomerase domain DUF4763 PF15960.5 ORX55128.1 - 0.00031 20.1 7.4 0.00068 19.0 7.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) FapA PF03961.13 ORX55128.1 - 0.00052 18.7 2.0 0.00092 17.9 2.0 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A SHE3 PF17078.5 ORX55128.1 - 0.0023 17.7 10.1 0.0023 17.7 10.1 1.8 2 1 0 2 2 1 1 SWI5-dependent HO expression protein 3 GAS PF13851.6 ORX55128.1 - 0.0063 15.9 8.4 0.0063 15.9 8.4 2.1 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ORX55128.1 - 0.014 16.0 13.7 0.014 16.0 13.7 1.8 2 0 0 2 2 1 0 Apg6 coiled-coil region KxDL PF10241.9 ORX55128.1 - 0.016 15.5 16.8 0.037 14.3 11.7 3.6 3 1 0 3 3 2 0 Uncharacterized conserved protein PID_2 PF14719.6 ORX55128.1 - 0.02 14.7 0.1 0.02 14.7 0.1 1.8 2 0 0 2 2 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF812 PF05667.11 ORX55128.1 - 0.03 13.2 10.6 0.032 13.1 7.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) BRE1 PF08647.11 ORX55128.1 - 0.035 14.2 10.4 0.024 14.7 7.5 2.2 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase ZapB PF06005.12 ORX55128.1 - 0.038 14.4 16.0 1.1 9.7 7.7 3.3 4 0 0 4 4 3 0 Cell division protein ZapB BLOC1_2 PF10046.9 ORX55128.1 - 0.11 12.8 4.9 0.5 10.7 3.6 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 IFT57 PF10498.9 ORX55128.1 - 0.15 11.0 10.1 0.039 12.9 5.1 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Exonuc_VII_L PF02601.15 ORX55128.1 - 0.18 11.4 12.8 0.14 11.7 8.3 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit OmpH PF03938.14 ORX55128.1 - 0.18 12.1 15.0 0.038 14.3 9.8 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Spc7 PF08317.11 ORX55128.1 - 0.38 9.6 13.4 0.032 13.1 8.8 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 ORX55128.1 - 0.42 9.9 15.0 0.027 13.8 9.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF2203 PF09969.9 ORX55128.1 - 0.43 11.3 5.7 2.9 8.6 3.1 2.6 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Gam PF06064.11 ORX55128.1 - 0.45 10.8 6.1 1.3 9.3 2.6 2.6 2 0 0 2 2 2 0 Host-nuclease inhibitor protein Gam Augurin PF15187.6 ORX55128.1 - 0.52 10.5 8.7 1.9 8.7 1.8 3.1 3 1 1 4 4 3 0 Oesophageal cancer-related gene 4 TMPIT PF07851.13 ORX55128.1 - 0.55 9.4 5.0 1.3 8.2 5.0 1.6 1 0 0 1 1 1 0 TMPIT-like protein DUF1204 PF06721.11 ORX55128.1 - 0.77 9.2 5.0 0.29 10.5 2.5 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF1204) UPF0242 PF06785.11 ORX55128.1 - 0.85 9.7 13.6 0.21 11.7 9.3 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF2408 PF10303.9 ORX55128.1 - 2.2 8.8 10.0 2.4 8.7 8.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) CREPT PF16566.5 ORX55128.1 - 2.3 8.4 11.4 0.34 11.1 5.6 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 ORX55128.1 - 3.5 7.7 16.9 0.31 11.1 11.5 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 ORX55128.1 - 4 8.1 13.8 2.5 8.8 6.9 3.6 4 1 1 5 5 3 0 Initiation control protein YabA FUSC PF04632.12 ORX55128.1 - 4.5 5.7 12.1 0.57 8.7 7.8 1.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family Fib_alpha PF08702.10 ORX55128.1 - 5.3 7.2 10.7 11 6.2 7.9 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 ORX55128.1 - 6.1 7.0 16.3 0.39 10.9 10.0 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Hemerythrin PF01814.23 ORX55128.1 - 6.2 7.5 9.6 15 6.3 2.9 3.4 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain Calc_CGRP_IAPP PF00214.19 ORX55128.1 - 6.9 7.1 6.8 3.5 8.0 3.9 2.1 2 0 0 2 2 1 0 Calcitonin / CGRP / IAPP family Lectin_N PF03954.14 ORX55128.1 - 8.6 6.1 15.3 6.6 6.5 10.7 3.2 2 1 1 3 3 3 0 Hepatic lectin, N-terminal domain DUF4140 PF13600.6 ORX55128.1 - 9 6.8 11.1 1.3e+02 3.1 8.5 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 ORX55128.1 - 9.4 6.1 12.5 29 4.5 9.0 2.8 1 1 1 2 2 2 0 Septum formation initiator Enkurin PF13864.6 ORX55128.1 - 9.8 6.7 14.7 7.3 7.1 9.8 2.7 3 0 0 3 3 2 0 Calmodulin-binding Cnn_1N PF07989.11 ORX55128.1 - 9.9 6.4 14.3 0.73 10.0 8.2 2.3 3 0 0 3 3 1 0 Centrosomin N-terminal motif 1 DUF647 PF04884.14 ORX55129.1 - 5.8e-50 170.2 0.1 7.7e-50 169.8 0.1 1.1 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis eIF3_subunit PF08597.10 ORX55130.1 - 1.7e-59 201.7 37.1 1.9e-59 201.5 37.1 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit Prominin PF05478.11 ORX55130.1 - 0.1 10.5 0.2 0.17 9.8 0.2 1.3 1 0 0 1 1 1 0 Prominin BMP2K_C PF15282.6 ORX55130.1 - 0.23 11.3 7.3 0.52 10.1 7.3 1.5 1 1 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus Peptidase_M19 PF01244.21 ORX55131.1 - 4.4e-108 361.2 0.1 4.9e-108 361.1 0.1 1.0 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) DUF2828 PF11443.8 ORX55136.1 - 1.6e-175 584.9 0.3 1.9e-175 584.6 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DUF1959 PF09218.10 ORX55136.1 - 0.077 13.1 0.0 10 6.3 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1959) Integrin_alpha2 PF08441.12 ORX55136.1 - 0.098 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Integrin alpha DUF2828 PF11443.8 ORX55137.1 - 3e-178 593.9 0.6 3.7e-178 593.5 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) DUF2828 PF11443.8 ORX55138.1 - 1.6e-161 538.6 0.6 2.1e-161 538.2 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) RabGAP-TBC PF00566.18 ORX55139.1 - 6.5e-41 140.3 0.1 1.5e-40 139.1 0.1 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain WD40 PF00400.32 ORX55140.1 - 1.6e-35 120.5 12.1 3.2e-07 30.9 0.1 7.7 8 0 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.8 ORX55140.1 - 6e-17 61.5 5.1 0.0016 17.2 0.1 6.0 1 1 5 6 6 6 4 Nucleoporin Nup120/160 F-box-like PF12937.7 ORX55140.1 - 4.9e-14 51.9 0.4 1.3e-13 50.6 0.4 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ORX55140.1 - 1.6e-09 37.9 2.1 0.027 14.7 0.0 4.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ORX55140.1 - 8.4e-09 35.1 0.0 1.9e-08 33.9 0.0 1.6 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 ORX55140.1 - 3e-06 26.8 0.0 0.07 12.4 0.1 2.2 2 0 0 2 2 2 2 WD40-like domain F-box_4 PF15966.5 ORX55140.1 - 0.0063 16.4 1.1 0.041 13.8 0.0 2.7 3 0 0 3 3 3 1 F-box BBS1 PF14779.6 ORX55140.1 - 0.038 13.4 0.0 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 HARP PF07443.13 ORX55140.1 - 0.075 12.7 0.0 0.51 10.0 0.0 2.5 3 0 0 3 3 3 0 HepA-related protein (HARP) MIP PF00230.20 ORX55142.1 - 3.6e-44 151.2 11.1 5.6e-44 150.5 11.1 1.2 1 0 0 1 1 1 1 Major intrinsic protein G3P_acyltransf PF02660.15 ORX55142.1 - 0.015 15.4 9.4 0.048 13.7 9.3 1.9 1 1 0 1 1 1 0 Glycerol-3-phosphate acyltransferase APC_r PF05923.12 ORX55142.1 - 1.3 8.8 8.7 0.15 11.8 2.8 2.3 2 0 0 2 2 2 0 APC repeat bZIP_2 PF07716.15 ORX55143.1 - 4.7e-09 36.2 13.6 4.7e-09 36.2 13.6 1.9 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX55143.1 - 9.4e-09 35.2 10.0 1.9e-08 34.3 10.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX55143.1 - 0.007 16.9 9.4 0.013 16.0 9.4 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor DivIC PF04977.15 ORX55143.1 - 0.1 12.4 3.7 0.098 12.4 2.1 1.8 1 1 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 ORX55143.1 - 0.2 11.7 4.4 0.28 11.3 4.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TPR_MLP1_2 PF07926.12 ORX55143.1 - 0.53 10.3 10.7 0.15 12.1 7.8 1.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein KIAA1328 PF15369.6 ORX55143.1 - 3.1 7.5 13.4 0.16 11.8 0.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein KIAA1328 Sec1 PF00995.23 ORX55144.1 - 3.3e-131 439.3 6.0 3.8e-131 439.1 6.0 1.0 1 0 0 1 1 1 1 Sec1 family Qua1 PF16274.5 ORX55144.1 - 0.12 12.3 0.1 0.33 10.8 0.1 1.7 1 0 0 1 1 1 0 Qua1 domain MFS_1 PF07690.16 ORX55145.1 - 4e-46 157.6 54.9 2.4e-43 148.4 55.0 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX55145.1 - 2.3e-15 56.0 25.8 3.2e-15 55.6 25.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX55145.1 - 8.2e-14 51.3 6.9 8.2e-14 51.3 6.9 3.2 3 0 0 3 3 3 1 Sugar (and other) transporter MitMem_reg PF13012.6 ORX55146.1 - 1.2e-25 90.0 0.7 2e-25 89.4 0.7 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ORX55146.1 - 2e-13 50.4 0.0 3.6e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease AAA PF00004.29 ORX55150.1 - 3.2e-41 140.9 0.0 6.3e-41 139.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ORX55150.1 - 5.1e-19 68.0 0.0 1e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ORX55150.1 - 8.5e-10 38.3 0.2 2.1e-09 37.0 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX55150.1 - 6.9e-06 26.1 0.1 3.5e-05 23.8 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX55150.1 - 1.4e-05 25.5 0.2 0.0054 17.1 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ORX55150.1 - 0.00011 22.0 0.0 0.00024 20.9 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX55150.1 - 0.00018 21.7 0.0 0.00087 19.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX55150.1 - 0.0007 19.9 0.5 0.069 13.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain PhoH PF02562.16 ORX55150.1 - 0.0009 18.7 0.1 0.02 14.4 0.0 2.2 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 ORX55150.1 - 0.0014 17.9 0.0 0.0026 17.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 ORX55150.1 - 0.0021 17.5 0.1 0.0081 15.6 0.0 2.0 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ORX55150.1 - 0.0031 17.7 0.1 0.0096 16.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX55150.1 - 0.024 14.4 0.0 0.043 13.6 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 ORX55150.1 - 0.049 13.1 0.1 0.11 12.0 0.1 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ORX55150.1 - 0.057 13.1 0.3 0.21 11.3 0.1 2.2 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 ORX55150.1 - 0.069 12.5 0.0 0.16 11.3 0.0 1.6 1 0 0 1 1 1 0 KaiC RNA_helicase PF00910.22 ORX55150.1 - 0.07 13.5 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_14 PF13173.6 ORX55150.1 - 0.071 13.1 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ORX55150.1 - 0.076 13.6 0.0 0.29 11.7 0.0 2.1 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX55150.1 - 0.087 12.5 0.0 0.27 10.9 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain CoA_transf_3 PF02515.17 ORX55151.1 - 7.1e-108 361.0 0.0 8.4e-108 360.8 0.0 1.1 1 0 0 1 1 1 1 CoA-transferase family III WD40 PF00400.32 ORX55153.1 - 2.3e-44 148.5 12.7 3.9e-07 30.6 0.3 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55153.1 - 3.1e-15 56.3 0.0 0.0047 17.2 0.0 5.9 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 ORX55153.1 - 5.7e-12 45.0 4.8 5.7e-12 45.0 4.8 2.3 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like Nbas_N PF15492.6 ORX55153.1 - 5.9e-05 22.5 0.2 0.3 10.4 0.0 3.5 2 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Ge1_WD40 PF16529.5 ORX55153.1 - 0.0098 14.9 0.0 29 3.5 0.0 4.0 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX55153.1 - 0.14 10.8 0.1 2.3 6.7 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PMT PF02366.18 ORX55154.1 - 1.8e-79 266.8 20.4 2.7e-79 266.2 20.4 1.3 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX55154.1 - 1.6e-59 200.9 2.6 1.6e-59 200.9 2.6 3.5 4 0 0 4 4 4 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX55154.1 - 1.8e-12 47.5 0.2 4.3e-12 46.2 0.2 1.7 1 1 0 1 1 1 1 MIR domain GCV_H PF01597.19 ORX55155.1 - 1.1e-44 151.3 0.9 1.3e-44 151.0 0.9 1.0 1 0 0 1 1 1 1 Glycine cleavage H-protein RnfC_N PF13375.6 ORX55155.1 - 0.00018 21.4 0.6 0.00032 20.6 0.5 1.5 1 1 0 1 1 1 1 RnfC Barrel sandwich hybrid domain Biotin_lipoyl PF00364.22 ORX55155.1 - 0.00022 21.0 0.9 0.0013 18.5 1.0 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme Oxidored_FMN PF00724.20 ORX55156.1 - 1.3e-98 330.5 0.0 1.5e-98 330.3 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Tautomerase PF01361.21 ORX55156.1 - 0.055 13.4 0.0 0.2 11.6 0.0 1.9 1 0 0 1 1 1 0 Tautomerase enzyme Ribophorin_II PF05817.14 ORX55157.1 - 9.9e-26 90.5 1.0 1e-25 90.4 1.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II WD40 PF00400.32 ORX55158.1 - 2.7e-11 43.8 0.4 0.0017 19.1 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55158.1 - 7.9e-07 29.3 0.0 0.24 11.7 0.0 4.6 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX55158.1 - 0.0056 16.0 0.2 0.015 14.7 0.1 1.6 1 1 1 2 2 2 1 WD40-like domain UQ_con PF00179.26 ORX55159.1 - 1.4e-54 183.6 0.0 1.5e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX55159.1 - 0.0027 18.0 0.0 0.0034 17.6 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 ORX55159.1 - 0.0079 15.9 0.0 0.0099 15.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ORX55159.1 - 0.059 13.2 0.0 0.089 12.7 0.0 1.3 1 0 0 1 1 1 0 UEV domain NAD_binding_10 PF13460.6 ORX55160.1 - 1e-10 41.8 0.0 1.8e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX55160.1 - 2.8e-09 36.9 0.0 3.7e-09 36.5 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family ARID PF01388.21 ORX55160.1 - 0.093 13.4 0.0 0.17 12.6 0.0 1.5 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain SET PF00856.28 ORX55161.1 - 1.6e-14 54.6 0.0 5.6e-13 49.6 0.0 2.2 1 1 0 1 1 1 1 SET domain zf-FLZ PF04570.14 ORX55161.1 - 0.75 9.3 6.0 1.9 8.0 0.3 2.7 2 0 0 2 2 2 0 zinc-finger of the FCS-type, C2-C2 TENA_THI-4 PF03070.16 ORX55162.1 - 1.5e-11 44.5 1.1 0.00012 21.9 0.2 2.2 2 0 0 2 2 2 2 TENA/THI-4/PQQC family Methyltransf_25 PF13649.6 ORX55164.1 - 4.2e-06 27.4 0.0 1.1e-05 26.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX55164.1 - 1.4e-05 25.0 0.0 2.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX55164.1 - 4.5e-05 24.0 0.0 8.3e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX55164.1 - 0.00056 20.6 0.0 0.0017 19.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX55164.1 - 0.0055 16.6 0.0 0.01 15.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ORX55164.1 - 0.0098 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PPR_2 PF13041.6 ORX55165.1 - 1.5e-52 175.6 2.9 2.6e-13 50.0 0.0 9.3 5 3 5 10 10 10 8 PPR repeat family PPR PF01535.20 ORX55165.1 - 2.9e-40 133.7 0.0 0.00036 20.6 0.0 11.8 12 0 0 12 12 12 9 PPR repeat PPR_3 PF13812.6 ORX55165.1 - 1.6e-32 111.3 0.2 7e-07 29.2 0.0 6.4 5 1 2 7 7 7 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX55165.1 - 8.6e-30 102.1 2.8 0.00047 19.8 0.0 9.8 10 0 0 10 10 10 6 PPR repeat PPR_long PF17177.4 ORX55165.1 - 2.7e-22 79.2 0.2 1.8e-08 34.0 0.3 4.0 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP TPR_19 PF14559.6 ORX55165.1 - 4.3e-06 27.1 5.9 0.007 16.8 0.1 5.1 5 1 1 6 6 6 2 Tetratricopeptide repeat RPM2 PF08579.11 ORX55165.1 - 0.00021 21.7 1.6 1.2 9.5 0.4 4.7 3 2 2 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) MRP-S27 PF10037.9 ORX55165.1 - 0.0012 17.8 2.3 2.5 6.9 0.1 3.5 2 1 0 3 3 3 2 Mitochondrial 28S ribosomal protein S27 TPR_14 PF13428.6 ORX55165.1 - 0.014 16.1 9.0 3.3 8.8 0.2 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat F-box-like PF12937.7 ORX55165.1 - 0.029 14.3 0.0 0.072 13.0 0.0 1.7 1 0 0 1 1 1 0 F-box-like BTAD PF03704.17 ORX55165.1 - 1.4 9.3 8.4 0.13 12.7 1.0 2.8 2 1 1 3 3 3 0 Bacterial transcriptional activator domain FAR1 PF03101.15 ORX55166.1 - 3.7e-06 27.6 1.1 7.5e-06 26.6 1.1 1.5 1 0 0 1 1 1 1 FAR1 DNA-binding domain Nop25 PF09805.9 ORX55167.1 - 0.0015 19.0 12.1 0.0015 19.0 12.1 2.3 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) AP3D1 PF06375.11 ORX55167.1 - 3.7 7.8 25.6 1.8 8.8 11.9 2.4 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 WD40 PF00400.32 ORX55168.1 - 1.2e-47 158.9 36.5 5.9e-09 36.4 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55168.1 - 2e-15 56.8 17.0 0.0055 17.0 0.3 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX55168.1 - 0.0022 17.9 5.3 0.0046 16.9 0.6 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Hemolysin_N PF12563.8 ORX55168.1 - 0.021 14.5 0.0 7.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Hemolytic toxin N terminal IKI3 PF04762.12 ORX55168.1 - 0.055 11.5 5.5 0.059 11.4 3.7 1.9 1 1 1 2 2 2 0 IKI3 family BBS2_Mid PF14783.6 ORX55168.1 - 0.11 12.5 3.0 2.4 8.2 0.0 3.8 4 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Coatomer_WDAD PF04053.14 ORX55168.1 - 0.73 8.8 6.2 1.2 8.1 1.5 2.8 2 1 0 2 2 2 0 Coatomer WD associated region DUF2387 PF09526.10 ORX55168.1 - 2.7 8.2 5.3 23 5.2 0.1 3.5 4 0 0 4 4 4 0 Probable metal-binding protein (DUF2387) Hydantoinase_B PF02538.14 ORX55169.1 - 3e-221 735.3 0.1 4.1e-221 734.9 0.1 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 ORX55169.1 - 3e-99 332.0 0.0 1.6e-98 329.5 0.0 2.0 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 ORX55169.1 - 5.8e-57 192.3 0.0 8.6e-55 185.2 0.0 2.4 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Ribosomal_L22 PF00237.19 ORX55170.1 - 1.9e-38 130.8 0.2 2.7e-38 130.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e CUTL PF16557.5 ORX55170.1 - 0.14 12.3 0.9 0.53 10.5 0.1 2.2 2 1 0 2 2 2 0 CUT1-like DNA-binding domain of SATB DUF3020 PF11223.8 ORX55171.1 - 6.1e-20 71.5 11.6 6.1e-20 71.5 11.6 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3020) Noggin PF05806.12 ORX55171.1 - 0.11 12.4 5.1 0.19 11.6 5.1 1.4 1 0 0 1 1 1 0 Noggin LPP20 PF02169.16 ORX55171.1 - 7.8 6.9 7.9 1.5 9.2 2.2 2.3 2 0 0 2 2 2 0 LPP20 lipoprotein Cofilin_ADF PF00241.20 ORX55172.1 - 5.8e-19 68.1 0.0 6.6e-19 67.9 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Coprogen_oxidas PF01218.18 ORX55173.1 - 1.6e-138 460.4 0.1 1.8e-138 460.2 0.1 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase NUDIX PF00293.28 ORX55174.1 - 3.4e-16 59.5 0.1 4.2e-16 59.2 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain DUF2428 PF10350.9 ORX55175.1 - 1.3e-80 270.7 0.0 4.2e-80 268.9 0.0 2.0 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 ORX55175.1 - 0.00063 19.8 3.3 57 4.4 0.1 6.7 5 0 0 5 5 5 0 HEAT repeat CP_ATPgrasp_2 PF14403.6 ORX55175.1 - 0.05 12.5 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 Hairy_orange PF07527.13 ORX55175.1 - 0.12 12.6 0.0 6.2 7.1 0.0 2.8 2 0 0 2 2 2 0 Hairy Orange NUP50 PF08911.11 ORX55176.1 - 0.022 15.4 0.0 0.07 13.8 0.0 1.8 1 0 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) Ran_BP1 PF00638.18 ORX55178.1 - 1.3e-16 60.9 0.0 2.2e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain TP53IP5 PF15331.6 ORX55178.1 - 1.9 8.6 6.4 1.1 9.4 3.0 2.0 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 DUF5089 PF17002.5 ORX55178.1 - 4.2 7.2 6.2 0.44 10.4 1.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5089) Cpn60_TCP1 PF00118.24 ORX55179.1 - 3.3e-158 527.3 2.7 3.8e-158 527.2 2.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PNTB_4TM PF12769.7 ORX55179.1 - 0.15 12.5 0.0 2 8.9 0.0 2.4 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch IBN_N PF03810.19 ORX55180.1 - 2.6e-13 49.7 0.4 2.5e-12 46.5 0.0 2.9 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 ORX55180.1 - 0.0054 15.6 0.0 0.021 13.6 0.0 2.1 2 0 0 2 2 2 1 Cse1 RIX1 PF08167.12 ORX55180.1 - 0.031 14.0 0.1 5.3 6.7 0.0 3.1 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Xpo1 PF08389.12 ORX55180.1 - 0.14 12.2 0.1 0.14 12.2 0.1 4.0 4 0 0 4 4 4 0 Exportin 1-like protein CAF1A PF12253.8 ORX55180.1 - 0.49 10.6 7.6 1.2 9.4 7.6 1.6 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A Peptidase_C97 PF05903.14 ORX55181.1 - 2.8e-39 134.4 0.0 4.7e-39 133.6 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain PUL PF08324.11 ORX55181.1 - 2.6e-32 112.2 1.2 2.6e-32 112.2 1.2 1.9 2 0 0 2 2 2 1 PUL domain Thioredoxin PF00085.20 ORX55181.1 - 1e-11 44.7 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX55181.1 - 0.00011 22.5 0.2 0.00047 20.6 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.10 ORX55181.1 - 0.015 15.0 0.1 0.04 13.6 0.0 1.7 2 0 0 2 2 2 0 Redoxin OST3_OST6 PF04756.13 ORX55181.1 - 0.029 13.7 0.1 0.048 13.0 0.1 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family HyaE PF07449.11 ORX55181.1 - 0.075 13.0 0.0 0.21 11.6 0.0 1.7 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.21 ORX55181.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family HSP70 PF00012.20 ORX55182.1 - 1.2e-06 27.1 0.0 1e-05 24.0 0.0 2.0 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ORX55182.1 - 0.048 12.5 0.0 0.51 9.1 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein PilM_2 PF11104.8 ORX55182.1 - 0.16 10.9 0.0 0.31 10.0 0.0 1.3 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; FdsD PF11390.8 ORX55186.1 - 1.1 9.7 4.8 16 5.9 0.4 2.3 2 0 0 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD OSR1_C PF12202.8 ORX55188.1 - 0.012 15.9 0.2 0.04 14.1 0.1 2.0 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain Myosin_head PF00063.21 ORX55189.1 - 1.6e-243 809.9 1.5 2e-243 809.6 1.5 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 ORX55189.1 - 3.9e-49 166.9 0.0 6.3e-49 166.2 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 ORX55189.1 - 4.7e-14 51.7 0.7 1e-13 50.6 0.7 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX55189.1 - 4.5e-12 45.6 0.2 1.4e-11 44.1 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX55189.1 - 1e-08 34.7 0.0 3.2e-08 33.1 0.0 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX55189.1 - 0.0013 18.9 0.5 0.0032 17.7 0.5 1.6 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 ORX55189.1 - 0.015 15.1 0.3 0.032 14.0 0.3 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain AAA_22 PF13401.6 ORX55189.1 - 0.028 14.7 0.1 0.088 13.1 0.1 1.8 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX55189.1 - 0.042 14.2 0.0 0.99 9.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase Hpr_kinase_C PF07475.12 ORX55189.1 - 0.048 13.2 0.5 12 5.4 0.0 2.6 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 ORX55189.1 - 0.07 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ORX55189.1 - 0.1 12.5 0.1 0.43 10.5 0.1 2.1 2 0 0 2 2 2 0 NACHT domain Histone PF00125.24 ORX55190.1 - 1.2e-17 64.5 0.1 1.5e-17 64.1 0.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ORX55190.1 - 1.6e-11 43.7 0.1 2.7e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ORX55190.1 - 0.00014 22.1 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CAF1 PF04857.20 ORX55191.1 - 1.8e-69 234.3 0.7 2.5e-69 233.9 0.7 1.2 1 0 0 1 1 1 1 CAF1 family ribonuclease Peptidase_S15 PF02129.18 ORX55191.1 - 0.0025 17.5 0.1 0.0045 16.6 0.1 1.4 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Mg_trans_NIPA PF05653.14 ORX55192.1 - 4.3e-21 75.3 20.0 9.3e-11 41.4 1.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ORX55192.1 - 7.6e-05 22.9 4.6 7.6e-05 22.9 4.6 3.0 3 0 0 3 3 3 1 EamA-like transporter family TMEM52 PF14979.6 ORX55192.1 - 0.093 12.6 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Transmembrane 52 Ac76 PF05814.11 ORX55192.1 - 9 6.4 7.5 5.1 7.2 4.4 2.2 2 0 0 2 2 2 0 Orf76 (Ac76) GLTP PF08718.11 ORX55193.1 - 2.9e-48 163.9 0.1 3.5e-48 163.7 0.1 1.1 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF2838 PF10998.8 ORX55194.1 - 6.6e-42 142.2 4.9 6.6e-42 142.2 4.9 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) Apolipoprotein PF01442.18 ORX55194.1 - 0.0039 17.1 3.8 0.0059 16.5 3.8 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Remorin_C PF03763.13 ORX55194.1 - 0.13 12.1 4.1 0.26 11.2 4.1 1.4 1 0 0 1 1 1 0 Remorin, C-terminal region Muted PF14942.6 ORX55194.1 - 0.15 12.4 3.3 0.21 11.9 3.3 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DAGAT PF03982.13 ORX55195.1 - 4.8e-94 314.6 0.0 6.3e-94 314.2 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Put_Phosphatase PF06888.12 ORX55196.1 - 6.3e-53 179.6 0.2 7.2e-53 179.4 0.2 1.0 1 0 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 ORX55196.1 - 5.4e-07 30.2 0.0 3e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX55196.1 - 0.017 15.2 1.3 0.96 9.5 1.4 2.5 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX55196.1 - 0.042 14.1 0.0 9 6.5 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase CNP1 PF08750.11 ORX55196.1 - 0.056 13.4 1.6 0.087 12.8 1.6 1.3 1 0 0 1 1 1 0 CNP1-like family HhH-GPD PF00730.25 ORX55197.1 - 4.2e-16 59.3 0.0 9.7e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ORX55197.1 - 2.3e-06 27.2 0.0 4.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ORX55197.1 - 0.0022 18.3 5.7 0.0036 17.6 5.7 1.4 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III DDE_Tnp_1_6 PF13751.6 ORX55197.1 - 0.033 14.4 0.3 0.069 13.4 0.3 1.5 1 0 0 1 1 1 0 Transposase DDE domain DUF3431 PF11913.8 ORX55197.1 - 0.079 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3431) DUF536 PF04394.14 ORX55197.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF536 HSF_DNA-bind PF00447.17 ORX55201.1 - 7.9e-33 113.0 2.2 1.6e-32 112.0 2.2 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding RasGAP_C PF03836.15 ORX55201.1 - 0.037 14.2 1.9 0.059 13.5 1.9 1.3 1 0 0 1 1 1 0 RasGAP C-terminus Cdc6_C PF09079.11 ORX55201.1 - 0.064 13.2 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain SlyX PF04102.12 ORX55201.1 - 0.076 13.6 3.0 0.17 12.6 3.0 1.7 1 0 0 1 1 1 0 SlyX Drc1-Sld2 PF11719.8 ORX55201.1 - 0.11 12.1 3.4 0.19 11.2 3.4 1.4 1 1 0 1 1 1 0 DNA replication and checkpoint protein DUF745 PF05335.13 ORX55201.1 - 0.2 11.4 2.2 0.29 10.9 2.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) ThrE PF06738.12 ORX55202.1 - 1.1e-37 129.7 17.3 5.5e-27 94.7 3.2 3.4 3 1 0 3 3 3 3 Putative threonine/serine exporter ThrE_2 PF12821.7 ORX55202.1 - 7.3e-14 52.0 21.5 7.3e-09 35.9 3.9 2.1 2 0 0 2 2 2 2 Threonine/Serine exporter, ThrE Stn1 PF10451.9 ORX55203.1 - 3e-10 39.5 0.2 4.1e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 tRNA_anti-codon PF01336.25 ORX55203.1 - 3.1e-09 36.7 0.7 9.4e-09 35.2 0.5 1.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 ORX55203.1 - 0.00025 20.9 0.2 0.00066 19.5 0.2 1.7 1 0 0 1 1 1 1 RecQ-mediated genome instability protein 2 Ribosomal_L44 PF00935.19 ORX55204.1 - 3.8e-38 129.8 11.1 5.3e-38 129.3 11.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 DEAD PF00270.29 ORX55205.1 - 4.2e-49 166.7 0.2 5.4e-48 163.1 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX55205.1 - 3.4e-31 107.9 0.1 1.4e-30 105.9 0.1 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX55205.1 - 2e-08 34.4 1.5 2.2e-06 27.8 0.0 3.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Peptidase_M16_M PF16187.5 ORX55207.1 - 3.6e-98 328.3 3.2 7.4e-98 327.3 3.2 1.6 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 ORX55207.1 - 3.8e-41 140.5 0.8 3.7e-40 137.3 0.2 2.6 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX55207.1 - 5.6e-38 130.8 0.1 1.7e-23 83.6 0.0 2.9 3 0 0 3 3 3 2 Peptidase M16 inactive domain HEPN PF05168.14 ORX55207.1 - 0.022 14.9 0.1 0.065 13.4 0.1 1.9 1 0 0 1 1 1 0 HEPN domain 2OG-FeII_Oxy_2 PF13532.6 ORX55208.1 - 1.7e-15 57.7 0.1 2e-12 47.7 0.1 2.4 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily Yip1 PF04893.17 ORX55208.1 - 2.8e-10 40.2 0.6 4e-10 39.7 0.6 1.2 1 0 0 1 1 1 1 Yip1 domain RasGEF PF00617.19 ORX55209.1 - 6.8e-50 169.7 5.1 9.6e-50 169.2 3.9 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ORX55209.1 - 2.1e-12 47.2 0.4 6.5e-12 45.6 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif WH2 PF02205.20 ORX55209.1 - 0.035 14.0 0.1 1 9.3 0.2 2.6 2 0 0 2 2 2 0 WH2 motif Atypical_Card PF18461.1 ORX55210.1 - 0.013 15.7 0.2 0.014 15.6 0.2 1.0 1 0 0 1 1 1 0 Atypical caspase recruitment domain Glyoxalase PF00903.25 ORX55211.1 - 1.2e-22 80.5 0.7 4.8e-16 59.1 0.1 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ORX55211.1 - 5.5e-10 39.5 0.0 0.00029 21.1 0.0 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ORX55211.1 - 2.5e-06 27.7 0.6 0.0049 17.0 0.1 3.5 3 2 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 ORX55211.1 - 2.8e-05 24.3 0.1 8.3e-05 22.8 0.1 1.8 1 1 0 1 1 1 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DUF1206 PF06724.11 ORX55212.1 - 0.12 12.5 2.5 0.12 12.4 0.3 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1206) DJ-1_PfpI PF01965.24 ORX55213.1 - 7.5e-42 142.9 0.3 8.7e-42 142.7 0.3 1.0 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ORX55213.1 - 0.061 13.0 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like VWA PF00092.28 ORX55213.1 - 0.13 12.5 0.1 0.19 11.9 0.1 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF4590 PF15257.6 ORX55214.1 - 0.027 14.4 0.1 0.065 13.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4590) Ta0938 PF11494.8 ORX55214.1 - 0.097 13.0 0.1 0.19 12.0 0.1 1.4 1 0 0 1 1 1 0 Ta0938 HEAT_2 PF13646.6 ORX55218.1 - 1.7e-26 92.4 1.5 8.4e-08 32.5 0.0 8.5 7 2 2 9 9 9 4 HEAT repeats HEAT PF02985.22 ORX55218.1 - 5.3e-24 82.2 11.9 0.00029 20.8 0.2 11.3 12 0 0 12 12 11 4 HEAT repeat HEAT_EZ PF13513.6 ORX55218.1 - 2.8e-18 66.0 5.0 2.2e-07 31.2 0.2 8.5 7 1 2 9 9 8 4 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ORX55218.1 - 8.3e-16 58.4 0.3 0.00014 22.3 0.0 7.9 7 1 2 9 9 8 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX55218.1 - 5.1e-13 49.4 7.4 5.2e-07 29.9 0.0 5.2 5 2 1 6 6 6 3 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX55218.1 - 1.7e-09 37.6 0.0 0.0068 16.0 0.0 4.9 4 2 1 5 5 5 2 CLASP N terminal IBN_N PF03810.19 ORX55218.1 - 9.3e-09 35.1 0.1 9.3e-09 35.1 0.1 4.0 6 0 0 6 6 4 1 Importin-beta N-terminal domain MMS19_C PF12460.8 ORX55218.1 - 1.1e-08 34.6 0.8 9.8e-05 21.6 0.0 4.5 3 2 2 5 5 5 1 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 ORX55218.1 - 6.4e-08 32.7 10.6 0.04 13.8 0.0 7.2 6 2 0 6 6 6 2 Domain of unknown function (DUF3385) IFRD PF05004.13 ORX55218.1 - 1.7e-07 30.7 0.4 0.13 11.3 0.0 4.6 2 1 2 4 4 4 2 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 ORX55218.1 - 1.5e-06 28.4 0.6 0.27 11.4 0.0 5.4 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Tti2 PF10521.9 ORX55218.1 - 2.9e-06 27.1 0.7 0.2 11.2 0.0 4.9 5 0 0 5 5 5 2 Tti2 family RIX1 PF08167.12 ORX55218.1 - 3.7e-06 26.8 0.3 0.14 11.9 0.1 4.6 4 1 1 5 5 5 2 rRNA processing/ribosome biogenesis DRIM PF07539.12 ORX55218.1 - 1.5e-05 23.5 3.8 0.32 9.3 0.1 5.3 4 3 1 5 5 5 2 Down-regulated in metastasis Arm PF00514.23 ORX55218.1 - 5e-05 23.2 0.9 14 5.9 0.1 5.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 ORX55218.1 - 6.2e-05 21.8 13.3 0.00089 17.9 0.1 5.2 4 2 1 5 5 5 2 Adaptin N terminal region ParcG PF10274.9 ORX55218.1 - 0.00012 22.2 2.3 0.26 11.4 0.0 4.6 4 1 1 5 5 4 1 Parkin co-regulated protein UME PF08064.13 ORX55218.1 - 0.00083 19.2 2.8 2.8 7.9 0.1 5.6 4 1 1 5 5 5 1 UME (NUC010) domain DUF3730 PF12530.8 ORX55218.1 - 0.0012 18.5 1.6 0.05 13.2 0.1 3.9 3 1 1 4 4 4 1 Protein of unknown function (DUF3730) CTD_bind PF04818.13 ORX55218.1 - 0.0057 17.4 0.1 41 5.1 0.0 4.5 3 0 0 3 3 3 0 RNA polymerase II-binding domain. Ipi1_N PF12333.8 ORX55218.1 - 0.017 15.7 0.2 0.53 10.9 0.0 3.6 5 0 0 5 5 3 0 Rix1 complex component involved in 60S ribosome maturation DUF4042 PF13251.6 ORX55218.1 - 0.023 14.4 3.5 0.46 10.2 0.3 4.6 3 2 0 4 4 4 0 Domain of unknown function (DUF4042) SpoVAD PF07451.11 ORX55218.1 - 0.13 11.0 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) RICTOR_V PF14668.6 ORX55218.1 - 0.15 12.3 1.9 3.5 7.9 0.0 4.1 5 0 0 5 5 4 0 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 ORX55218.1 - 1.7 8.8 5.8 12 6.1 0.0 4.8 7 0 0 7 7 5 0 V-ATPase subunit H Ribosomal_S24e PF01282.19 ORX55220.1 - 8.2e-35 118.6 0.0 1.4e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e EzrA PF06160.12 ORX55530.1 - 0.00092 17.5 3.8 0.0014 16.9 3.8 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA KxDL PF10241.9 ORX55530.1 - 0.002 18.3 7.0 0.0045 17.2 7.0 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein Virulence_fact PF13769.6 ORX55530.1 - 0.062 13.5 1.1 0.17 12.1 1.1 1.7 1 0 0 1 1 1 0 Virulence factor DUF2353 PF09789.9 ORX55530.1 - 0.18 11.2 13.9 0.045 13.1 10.3 1.8 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Sigma70_ner PF04546.13 ORX55530.1 - 0.45 10.4 19.0 7 6.5 19.0 2.2 1 1 0 1 1 1 0 Sigma-70, non-essential region Adaptin_binding PF10199.9 ORX55530.1 - 0.51 11.0 19.9 12 6.6 19.9 2.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 FapA PF03961.13 ORX55530.1 - 0.51 8.9 4.6 0.78 8.3 4.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A SpoIIIAH PF12685.7 ORX55530.1 - 1.5 8.6 16.3 2.4 7.9 16.3 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein FAM76 PF16046.5 ORX55530.1 - 3.2 7.0 15.2 4.8 6.4 15.2 1.2 1 0 0 1 1 1 0 FAM76 protein Sporozoite_P67 PF05642.11 ORX55530.1 - 7.4 4.5 10.9 80 1.1 0.0 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DnaJ PF00226.31 ORX55531.1 - 1.7e-17 63.3 0.5 1.7e-17 63.3 0.5 1.9 2 0 0 2 2 2 1 DnaJ domain WD40 PF00400.32 ORX55532.1 - 4.5e-17 62.1 8.2 1.8e-05 25.4 0.0 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55532.1 - 8.6e-15 54.8 0.0 7.5e-05 23.0 0.0 5.3 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ORX55532.1 - 5.3e-06 26.2 0.0 7.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 PQQ-like domain DUF1513 PF07433.11 ORX55532.1 - 0.0098 15.0 0.0 4.9 6.2 0.0 2.8 2 1 0 2 2 2 2 Protein of unknown function (DUF1513) WD40_like PF17005.5 ORX55532.1 - 0.014 14.7 0.1 0.52 9.6 0.0 2.7 2 2 1 3 3 3 0 WD40-like domain NUP214 PF16755.5 ORX55532.1 - 0.02 14.1 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 PQQ PF01011.21 ORX55532.1 - 0.12 12.4 0.1 5 7.2 0.0 2.8 3 0 0 3 3 3 0 PQQ enzyme repeat RAB3GAP2_N PF14655.6 ORX55532.1 - 0.14 11.4 0.0 0.3 10.3 0.0 1.5 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Beach PF02138.18 ORX55533.1 - 2.7e-41 141.8 0.1 5e-41 140.9 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain Pkinase PF00069.25 ORX55533.1 - 1.4e-06 27.9 0.0 3.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX55533.1 - 0.033 13.5 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Kinase-like PF14531.6 ORX55533.1 - 0.045 13.1 0.0 0.091 12.1 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF1249 PF06853.12 ORX55533.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1249) AIRC PF00731.20 ORX55535.1 - 3.2e-62 208.5 2.0 7.5e-62 207.3 2.0 1.7 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 ORX55535.1 - 1.6e-61 206.8 0.0 2.7e-61 206.1 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 ORX55535.1 - 4.2e-20 71.2 0.0 1.1e-19 69.9 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain AlaDh_PNT_C PF01262.21 ORX55535.1 - 8.7e-05 21.9 0.6 0.00026 20.3 0.4 2.0 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Dala_Dala_lig_C PF07478.13 ORX55535.1 - 0.00044 19.9 0.0 0.002 17.7 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus 3HCDH_N PF02737.18 ORX55535.1 - 0.002 18.0 0.2 0.0047 16.8 0.2 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ORX55535.1 - 0.0031 16.9 0.1 0.0055 16.1 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CPSase_L_D2 PF02786.17 ORX55535.1 - 0.0035 16.9 0.0 0.006 16.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain NAD_binding_2 PF03446.15 ORX55535.1 - 0.056 13.6 0.5 0.23 11.6 0.1 2.4 2 1 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ORX55535.1 - 0.068 13.8 0.2 0.19 12.3 0.2 1.8 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent PrpR_N PF06506.11 ORX55535.1 - 0.069 12.7 0.5 1 8.9 0.0 2.7 2 1 1 3 3 3 0 Propionate catabolism activator CoA_binding_2 PF13380.6 ORX55535.1 - 0.082 13.4 1.2 99 3.5 0.0 4.1 3 1 0 4 4 4 0 CoA binding domain Radical_SAM PF04055.21 ORX55535.1 - 0.15 12.4 0.0 0.8 10.1 0.0 2.2 3 0 0 3 3 3 0 Radical SAM superfamily Melibiase_C PF17801.1 ORX55538.1 - 8.4e-15 54.6 0.0 1.5e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2 PF16499.5 ORX55538.1 - 1.4e-09 37.6 1.7 0.0013 18.0 0.5 3.1 2 1 1 3 3 3 2 Alpha galactosidase A Melibiase PF02065.18 ORX55538.1 - 0.057 12.4 0.0 0.097 11.6 0.0 1.4 1 1 0 1 1 1 0 Melibiase Melibiase_2_C PF17450.2 ORX55538.1 - 0.17 12.1 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain Syntaxin PF00804.25 ORX55541.1 - 4.8e-08 32.9 6.2 7.1e-08 32.4 6.2 1.2 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 ORX55541.1 - 9.7e-07 28.7 0.5 3.1e-06 27.1 0.5 1.9 1 0 0 1 1 1 1 SNARE domain FAM167 PF11652.8 ORX55541.1 - 0.23 12.0 3.0 1.1 9.8 0.1 2.8 3 0 0 3 3 3 0 FAM167 EF-G-binding_N PF07299.11 ORX55541.1 - 0.32 11.5 7.1 0.13 12.8 1.3 3.1 2 1 2 4 4 4 0 Elongation factor G-binding protein, N-terminal FlaC_arch PF05377.11 ORX55541.1 - 6.6 7.2 8.4 0.77 10.2 0.4 3.2 5 0 0 5 5 5 0 Flagella accessory protein C (FlaC) DUF16 PF01519.16 ORX55541.1 - 8 7.0 12.4 0.24 11.9 3.2 2.5 3 0 0 3 3 3 0 Protein of unknown function DUF16 Med25_VWA PF11265.8 ORX55542.1 - 4.8e-32 111.5 0.1 1.2e-31 110.2 0.1 1.7 1 0 0 1 1 1 1 Mediator complex subunit 25 von Willebrand factor type A VWA_2 PF13519.6 ORX55542.1 - 0.071 13.8 0.0 0.071 13.8 0.0 3.6 3 1 0 3 3 3 0 von Willebrand factor type A domain Pro_isomerase PF00160.21 ORX55543.1 - 5.9e-47 159.9 0.0 6.7e-47 159.7 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RhoGAP PF00620.27 ORX55544.1 - 2.2e-37 128.2 0.0 3.3e-37 127.7 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain RasGAP PF00616.19 ORX55545.1 - 1.4e-17 64.1 0.1 3.3e-10 40.0 0.0 2.5 1 1 1 2 2 2 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ORX55545.1 - 2.6e-12 47.1 0.3 7.5e-12 45.6 0.3 1.9 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain HEAT PF02985.22 ORX55545.1 - 3.8e-05 23.6 0.4 2.5 8.6 0.0 4.9 5 0 0 5 5 5 2 HEAT repeat CRAL_TRIO PF00650.20 ORX55545.1 - 0.0014 18.4 0.8 0.0032 17.2 0.1 2.0 2 0 0 2 2 2 1 CRAL/TRIO domain HEAT_2 PF13646.6 ORX55545.1 - 0.041 14.3 0.2 86 3.6 0.0 5.1 5 0 0 5 5 5 0 HEAT repeats Arm PF00514.23 ORX55545.1 - 0.084 12.9 1.9 0.2 11.8 0.2 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat OSR1_C PF12202.8 ORX55546.1 - 0.028 14.6 0.2 0.077 13.2 0.2 1.9 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Peptidase_S78 PF04586.17 ORX55546.1 - 0.043 14.0 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 Caudovirus prohead serine protease Opi1 PF08618.10 ORX55547.1 - 1.9e-50 172.4 17.6 8.6e-44 150.4 7.6 3.7 2 1 2 4 4 4 3 Transcription factor Opi1 Ipi1_N PF12333.8 ORX55547.1 - 0.042 14.4 1.2 0.49 11.0 0.4 2.7 2 1 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation Peptidase_C50 PF03568.17 ORX55548.1 - 9.3e-32 110.6 0.3 1.1e-31 110.4 0.3 1.1 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 ORX55548.1 - 1.8e-05 24.3 0.0 2.2e-05 24.0 0.0 1.0 1 0 0 1 1 1 1 CHAT domain Peptidase_C50 PF03568.17 ORX55549.1 - 6.9e-68 229.6 0.0 8.1e-68 229.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family C50 TPR_MalT PF17874.1 ORX55550.1 - 2.3e-05 23.9 0.2 2.5e-05 23.8 0.2 1.1 1 0 0 1 1 1 1 MalT-like TPR region TPR_12 PF13424.6 ORX55550.1 - 0.00016 21.9 0.2 0.00038 20.7 0.3 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX55550.1 - 0.00084 19.3 0.2 0.044 13.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX55550.1 - 0.0014 18.7 0.2 0.0054 16.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX55550.1 - 0.0033 17.9 0.2 0.0064 17.0 0.2 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX55550.1 - 0.0068 17.1 0.6 0.044 14.6 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX55550.1 - 0.021 14.5 0.0 0.094 12.4 0.0 2.0 2 0 0 2 2 2 0 TPR repeat TPR_4 PF07721.14 ORX55550.1 - 0.084 13.5 0.7 1.4 9.8 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX55550.1 - 0.12 13.0 0.1 0.46 11.2 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55551.1 - 0.01 16.1 0.1 0.026 14.8 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat YacG PF03884.14 ORX55552.1 - 0.023 14.4 0.2 0.33 10.7 0.1 2.6 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG HZS_alpha PF18582.1 ORX55552.1 - 0.11 13.0 0.1 19 5.8 0.0 2.9 2 1 0 3 3 3 0 Hydrazine synthase alpha subunit middle domain DUF2122 PF09895.9 ORX55553.1 - 0.16 12.3 0.1 0.25 11.7 0.1 1.3 1 0 0 1 1 1 0 RecB-family nuclease (DUF2122) MWFE PF15879.5 ORX55554.1 - 0.19 12.0 0.8 0.54 10.5 0.0 2.0 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit WD40 PF00400.32 ORX55556.1 - 2.7e-26 91.3 12.1 1.4e-05 25.7 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55556.1 - 7.4e-07 29.4 0.7 0.0058 16.9 0.1 3.8 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ORX55556.1 - 0.00064 20.1 0.1 7.1 7.3 0.0 4.4 4 0 0 4 4 4 1 PQQ-like domain Nup160 PF11715.8 ORX55556.1 - 0.0068 15.1 0.3 3.4 6.2 0.1 3.4 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Reg_prop PF07494.11 ORX55556.1 - 0.012 15.7 0.2 13 6.5 0.1 3.1 2 0 0 2 2 2 0 Two component regulator propeller TetM_leader PF08076.11 ORX55556.1 - 3.7 7.4 5.8 24 4.8 0.0 3.2 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide Rft-1 PF04506.13 ORX55558.1 - 0.1 11.3 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 Rft protein Tim17 PF02466.19 ORX55559.1 - 1.6e-09 38.1 2.5 2.9e-08 34.1 0.2 2.6 3 0 0 3 3 3 1 Tim17/Tim22/Tim23/Pmp24 family TMEM135_C_rich PF15982.5 ORX55559.1 - 1.2e-07 32.4 3.0 3.8e-07 30.8 1.0 2.2 2 0 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 EI24 PF07264.11 ORX55560.1 - 6.3e-09 36.3 16.7 3.1e-07 30.8 16.7 2.2 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Promethin PF16015.5 ORX55560.1 - 3.4 7.7 13.9 0.13 12.2 0.4 3.4 3 1 1 4 4 4 0 Promethin F-box PF00646.33 ORX55561.1 - 1.1e-05 25.2 0.1 2.1e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX55561.1 - 3.8e-05 23.5 0.7 3.8e-05 23.5 0.7 1.7 2 0 0 2 2 2 1 F-box-like Ribosomal_L35p PF01632.19 ORX55562.1 - 3.9e-16 59.3 1.5 4.6e-16 59.1 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 zf-C4H2 PF10146.9 ORX55563.1 - 2.3e-09 37.9 11.6 2.9e-09 37.6 11.6 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein TMEM215 PF15746.5 ORX55563.1 - 0.019 14.4 3.4 0.025 14.0 2.4 1.5 1 1 0 1 1 1 0 TMEM215 family UPF0270 PF06794.12 ORX55563.1 - 0.059 13.4 0.4 0.13 12.3 0.3 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0270) CTK3_C PF12350.8 ORX55563.1 - 0.1 12.8 2.1 0.44 10.7 0.6 2.4 2 0 0 2 2 2 0 CTD kinase subunit gamma CTK3 C-terminus Sec16 PF12932.7 ORX55563.1 - 7.4 7.2 6.9 0.95 10.1 1.5 2.1 2 1 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region PrgU PF09627.10 ORX55564.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 PrgU-like protein SR-25 PF10500.9 ORX55565.1 - 0.034 13.7 9.4 0.036 13.7 9.4 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3678 PF12435.8 ORX55565.1 - 7.7 6.0 15.8 0.14 11.5 5.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3678) Methyltransf_11 PF08241.12 ORX55566.1 - 2.2e-07 31.4 0.0 4.5e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX55566.1 - 1.4e-06 28.3 0.0 4.8e-06 26.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX55566.1 - 5.1e-05 23.9 0.0 0.00012 22.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX55566.1 - 0.00057 19.3 0.0 0.0013 18.1 0.0 1.6 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX55566.1 - 0.0051 16.6 0.0 0.0083 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX55566.1 - 0.028 15.2 0.0 0.1 13.3 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain SHQ1 PF04925.15 ORX55567.1 - 3.4e-70 235.2 4.8 5.2e-70 234.6 4.8 1.3 1 0 0 1 1 1 1 SHQ1 protein AAA_5 PF07728.14 ORX55569.1 - 5.9e-91 301.7 0.0 5e-36 123.7 0.0 3.9 4 0 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX55569.1 - 6.1e-09 36.5 3.1 0.071 13.5 0.1 5.5 3 2 0 5 5 5 2 AAA ATPase domain AAA_3 PF07726.11 ORX55569.1 - 1.8e-05 24.6 0.1 1.3 8.9 0.0 3.6 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) CbbQ_C PF08406.10 ORX55569.1 - 0.00011 22.4 0.0 0.22 11.8 0.1 2.8 2 0 0 2 2 2 2 CbbQ/NirQ/NorQ C-terminal MCM PF00493.23 ORX55569.1 - 0.0026 16.9 0.1 0.029 13.5 0.0 2.4 2 0 0 2 2 2 1 MCM P-loop domain Med29 PF11568.8 ORX55569.1 - 0.0036 17.5 0.3 0.012 15.8 0.3 1.8 1 0 0 1 1 1 1 Mediator complex subunit 29 AAA_22 PF13401.6 ORX55569.1 - 0.011 16.0 1.0 19 5.5 0.0 4.5 3 2 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 ORX55569.1 - 0.059 12.7 0.2 6.9 6.0 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Csm2_III-A PF03750.13 ORX55569.1 - 0.067 14.0 0.5 0.19 12.6 0.1 2.0 2 0 0 2 2 2 0 Csm2 Type III-A EPL1 PF10513.9 ORX55570.1 - 4.9e-21 75.8 0.3 1.3e-20 74.4 0.3 1.7 1 0 0 1 1 1 1 Enhancer of polycomb-like Peptidase_M1 PF01433.20 ORX55571.1 - 1.8e-84 282.7 1.9 2.7e-84 282.1 1.9 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ORX55571.1 - 4.1e-78 263.1 2.1 2.5e-76 257.2 1.5 2.3 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ORX55571.1 - 4.5e-53 180.2 0.7 7.2e-53 179.5 0.7 1.3 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain UPF0121 PF03661.13 ORX55572.1 - 1.2e-45 155.8 9.6 1.6e-45 155.4 9.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) zf-UBR PF02207.20 ORX55573.1 - 1.2e-19 70.2 9.9 1.2e-19 70.2 9.9 2.6 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 ORX55573.1 - 5.3e-07 29.3 0.1 1.4e-06 28.0 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS Ribonuclease_P PF00825.18 ORX55574.1 - 2.8e-06 27.4 0.7 2.9e-06 27.3 0.7 1.0 1 0 0 1 1 1 1 Ribonuclease P zf-C2H2 PF00096.26 ORX55575.1 - 0.0013 19.1 3.0 0.0013 19.1 3.0 1.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX55575.1 - 1.1 10.3 5.1 1 10.4 3.4 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger MFS_1 PF07690.16 ORX55576.1 - 2.4e-44 151.7 38.8 2.4e-44 151.7 38.8 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX55576.1 - 5.3e-18 65.1 7.1 5.3e-18 65.1 7.1 3.4 2 1 2 4 4 4 1 Sugar (and other) transporter TRI12 PF06609.13 ORX55576.1 - 2.6e-12 46.0 13.4 2.6e-12 46.0 13.4 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) GatB_N PF02934.15 ORX55577.1 - 1.5e-103 346.0 0.0 1.8e-103 345.7 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 ORX55577.1 - 3.8e-37 127.4 0.0 5.4e-37 126.9 0.0 1.2 1 0 0 1 1 1 1 GatB domain RasGAP PF00616.19 ORX55578.1 - 1.8e-12 47.4 0.0 1.8e-07 31.1 0.0 3.5 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ORX55578.1 - 3.5e-12 46.6 5.9 3.6e-12 46.6 2.1 2.8 3 0 0 3 3 3 1 Divergent CRAL/TRIO domain NuiA PF07924.11 ORX55578.1 - 0.0069 16.8 0.1 0.39 11.1 0.0 3.3 3 0 0 3 3 3 1 Nuclease A inhibitor-like protein CRAL_TRIO PF00650.20 ORX55578.1 - 0.013 15.3 1.0 0.056 13.2 1.0 2.1 1 0 0 1 1 1 0 CRAL/TRIO domain FlxA PF14282.6 ORX55580.1 - 7.7 6.6 8.2 22 5.1 0.0 2.8 3 0 0 3 3 3 0 FlxA-like protein Pro_isomerase PF00160.21 ORX55581.1 - 3.9e-49 166.9 0.5 4.9e-49 166.6 0.5 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GCP_N_terminal PF17681.1 ORX55582.1 - 4.2e-91 305.8 0.4 8.5e-91 304.8 0.4 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ORX55582.1 - 7.4e-80 268.7 1.7 7.4e-80 268.7 1.7 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal zf-C2H2 PF00096.26 ORX55583.1 - 1.5e-11 44.0 10.2 6.1e-06 26.4 1.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX55583.1 - 2.3e-07 30.9 3.6 2.3e-07 30.9 3.6 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX55583.1 - 1.5e-06 28.5 8.3 0.0041 17.8 1.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX55583.1 - 0.002 18.3 1.2 0.0027 17.9 1.2 1.2 1 0 0 1 1 1 1 Aberrant zinc-finger FOXP-CC PF16159.5 ORX55583.1 - 0.035 14.7 1.7 0.5 11.0 0.2 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain OrsD PF12013.8 ORX55583.1 - 0.038 14.4 1.8 3.6 8.1 0.1 2.3 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-H2C2_5 PF13909.6 ORX55583.1 - 0.11 12.3 10.1 0.99 9.2 1.0 3.2 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Maf1 PF09174.10 ORX55584.1 - 2.7e-33 115.6 6.5 1.2e-27 97.2 0.0 2.4 2 1 1 3 3 3 2 Maf1 regulator COBRA1 PF06209.13 ORX55586.1 - 2.8e-43 148.5 6.1 5e-43 147.6 6.0 1.4 1 1 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) VHS PF00790.19 ORX55587.1 - 6.7e-11 42.2 0.4 8.7e-11 41.8 0.4 1.2 1 0 0 1 1 1 1 VHS domain ENTH PF01417.20 ORX55587.1 - 0.022 14.8 1.1 0.051 13.6 0.9 1.8 1 1 0 1 1 1 0 ENTH domain Peptidase_M1 PF01433.20 ORX55588.1 - 2.6e-44 151.4 0.0 3.6e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ORX55588.1 - 5.2e-34 116.7 0.1 8.8e-34 116.0 0.1 1.4 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 ORX55588.1 - 3.4e-29 102.3 0.0 5.2e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Tmemb_18A PF09771.9 ORX55589.1 - 1.7 9.1 7.6 4.7 7.6 0.8 2.8 3 0 0 3 3 3 0 Transmembrane protein 188 TIMELESS PF04821.14 ORX55590.1 - 2e-55 188.0 2.2 1.4e-54 185.3 0.0 2.5 3 0 0 3 3 3 1 Timeless protein TIMELESS_C PF05029.13 ORX55590.1 - 2e-07 30.6 7.5 1.1e-06 28.1 2.8 2.3 2 0 0 2 2 2 2 Timeless protein C terminal region TPR_19 PF14559.6 ORX55591.1 - 1.2e-07 32.1 0.8 0.012 16.1 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX55591.1 - 8.4e-05 22.5 0.4 0.49 10.7 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55591.1 - 0.0001 22.5 0.9 0.01 16.1 0.2 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX55591.1 - 0.00019 20.9 3.4 0.00025 20.5 1.8 1.8 1 1 1 2 2 2 1 MalT-like TPR region ChAPs PF09295.10 ORX55591.1 - 0.0013 17.8 0.5 0.0015 17.6 0.5 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 ORX55591.1 - 0.0068 16.4 0.1 1.3 9.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Mad3_BUB1_I_2 PF17014.5 ORX55591.1 - 0.0076 16.4 0.5 0.25 11.5 0.1 2.3 1 1 1 2 2 2 1 Putative Mad3/BUB1 like region 1 protein ANAPC3 PF12895.7 ORX55591.1 - 0.0098 16.1 3.1 0.039 14.2 2.9 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ORX55591.1 - 0.014 16.1 0.3 2.9 9.0 0.0 3.2 1 1 3 4 4 4 0 Tetratricopeptide repeat DUF2989 PF11207.8 ORX55591.1 - 0.16 11.7 3.6 0.065 13.0 0.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2989) ANAPC5 PF12862.7 ORX55592.1 - 3.2e-24 84.8 1.5 1e-23 83.2 1.5 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 Cellulase PF00150.18 ORX55592.1 - 0.038 13.4 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) TRAP_alpha PF03896.16 ORX55596.1 - 3.4e-17 62.6 0.0 4.7e-17 62.1 0.0 1.3 1 1 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit FtsH_ext PF06480.15 ORX55596.1 - 0.041 14.2 0.3 4.8 7.6 0.1 2.6 3 0 0 3 3 3 0 FtsH Extracellular Pkinase PF00069.25 ORX55597.1 - 1.1e-54 185.5 0.0 1.4e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX55597.1 - 2e-33 115.8 0.0 2.4e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX55597.1 - 7e-05 22.9 0.0 0.0015 18.5 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX55597.1 - 0.00096 18.5 0.0 0.0018 17.7 0.0 1.4 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX55597.1 - 0.002 17.1 0.1 0.0026 16.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX55597.1 - 0.0031 16.9 0.1 0.0046 16.3 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TEP1_N PF05386.11 ORX55597.1 - 0.014 15.0 0.9 0.035 13.7 0.9 1.7 1 0 0 1 1 1 0 TEP1 N-terminal domain FTA2 PF13095.6 ORX55597.1 - 0.057 13.0 0.0 0.086 12.5 0.0 1.4 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Choline_kinase PF01633.20 ORX55597.1 - 0.089 12.4 0.1 0.14 11.7 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kre28 PF17097.5 ORX55597.1 - 0.2 10.6 0.0 0.28 10.1 0.0 1.1 1 0 0 1 1 1 0 Spindle pole body component MFS_1 PF07690.16 ORX55598.1 - 2.2e-43 148.5 42.3 2.2e-43 148.5 42.3 2.3 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX55598.1 - 2.8e-12 46.3 28.4 2.8e-11 43.0 6.8 2.8 2 1 1 3 3 3 2 Sugar (and other) transporter DUF1294 PF06961.13 ORX55598.1 - 0.13 12.5 0.6 1.7 8.9 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1294) DUF3784 PF12650.7 ORX55598.1 - 0.14 12.3 0.0 0.14 12.3 0.0 3.9 3 2 1 4 4 4 0 Domain of unknown function (DUF3784) HlyD_3 PF13437.6 ORX55598.1 - 0.18 12.5 0.1 0.36 11.6 0.1 1.4 1 0 0 1 1 1 0 HlyD family secretion protein Dexa_ind PF15198.6 ORX55598.1 - 1.4 9.1 4.9 1.1 9.4 0.2 2.9 3 1 0 3 3 3 0 Dexamethasone-induced Ebp2 PF05890.12 ORX55599.1 - 1.6e-18 67.2 6.1 3.2e-17 63.0 0.1 2.0 1 1 1 2 2 2 2 Eukaryotic rRNA processing protein EBP2 Mitoc_L55 PF09776.9 ORX55599.1 - 0.017 14.8 0.8 0.035 13.8 0.8 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 ANAPC5 PF12862.7 ORX55600.1 - 0.03 14.4 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 Ribosomal_60s PF00428.19 ORX55600.1 - 0.2 12.3 1.2 0.57 10.8 1.2 1.9 1 1 0 1 1 1 0 60s Acidic ribosomal protein tRNA_m1G_MT PF01746.21 ORX55601.1 - 8e-35 120.3 0.4 1.2e-34 119.7 0.4 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase MSA-2c PF12238.8 ORX55601.1 - 0.081 12.9 7.3 0.062 13.3 5.1 2.1 1 1 1 2 2 2 0 Merozoite surface antigen 2c TMEM51 PF15345.6 ORX55602.1 - 0.0014 18.5 0.1 0.0014 18.5 0.1 1.7 1 1 1 2 2 2 1 Transmembrane protein 51 RCR PF12273.8 ORX55602.1 - 0.0087 16.7 3.0 0.014 16.1 3.0 1.5 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red EphA2_TM PF14575.6 ORX55602.1 - 0.012 16.4 0.0 0.013 16.3 0.0 1.2 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain THEG4 PF15834.5 ORX55602.1 - 0.013 15.5 0.0 0.016 15.3 0.0 1.0 1 0 0 1 1 1 0 Testis highly expressed protein 4 WBP-1 PF11669.8 ORX55602.1 - 0.014 16.0 1.1 0.019 15.6 1.1 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 DUF2207 PF09972.9 ORX55602.1 - 0.079 11.7 0.0 0.093 11.5 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4381 PF14316.6 ORX55602.1 - 0.097 12.9 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) zf-H2C2_2 PF13465.6 ORX55603.1 - 5.7e-10 39.2 4.3 9.9e-06 25.8 0.0 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX55603.1 - 3.3e-06 27.3 1.4 6.7e-05 23.1 0.1 3.6 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX55603.1 - 1.8e-05 25.1 11.4 0.0045 17.7 0.1 3.6 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 ORX55603.1 - 0.00055 20.5 15.5 0.002 18.7 0.4 4.0 2 1 2 4 4 4 2 FOXP coiled-coil domain GIT_CC PF16559.5 ORX55603.1 - 0.022 14.6 0.2 0.043 13.7 0.2 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Zap1_zf2 PF18217.1 ORX55603.1 - 0.26 11.3 5.9 6.2 6.9 0.6 2.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 zf-C2H2_6 PF13912.6 ORX55603.1 - 2.1 8.4 6.1 1.2 9.2 0.1 3.2 3 1 0 3 3 3 0 C2H2-type zinc finger zf_ZIC PF18366.1 ORX55603.1 - 2.4 8.4 0.0 2.4 8.4 0.0 3.6 4 1 0 4 4 4 0 Zic proteins zinc finger domain NUC173 PF08161.12 ORX55604.1 - 6.4e-64 215.4 8.3 2.7e-61 206.8 0.1 4.8 5 0 0 5 5 5 3 NUC173 domain UME PF08064.13 ORX55604.1 - 0.61 10.0 3.9 49 3.9 0.2 4.5 4 0 0 4 4 4 0 UME (NUC010) domain Xpo1 PF08389.12 ORX55604.1 - 0.61 10.1 8.6 2.2 8.3 0.2 4.6 5 1 0 5 5 5 0 Exportin 1-like protein RIH_assoc PF08454.11 ORX55604.1 - 8.1 6.4 6.3 17 5.4 2.5 3.4 2 1 0 2 2 2 0 RyR and IP3R Homology associated Brix PF04427.18 ORX55607.1 - 1.8e-39 135.9 0.8 2.8e-39 135.2 0.8 1.3 1 0 0 1 1 1 1 Brix domain Usp PF00582.26 ORX55607.1 - 0.017 15.7 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Universal stress protein family Mus7 PF09462.10 ORX55611.1 - 0.11 11.3 0.6 0.15 10.9 0.6 1.1 1 0 0 1 1 1 0 Mus7/MMS22 family Crr6 PF08847.11 ORX55612.1 - 0.014 15.1 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Chlororespiratory reduction 6 OrfB_Zn_ribbon PF07282.11 ORX55613.1 - 1.7e-09 37.5 2.7 2.8e-09 36.8 2.7 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX55613.1 - 0.21 11.2 1.3 0.38 10.4 1.3 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal GLE1 PF07817.13 ORX55615.1 - 3.3e-50 170.6 0.1 3.3e-50 170.6 0.1 1.7 2 0 0 2 2 2 1 GLE1-like protein BNIP2 PF12496.8 ORX55615.1 - 2.3 8.6 7.6 5.4 7.5 6.7 2.0 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 PGP_phosphatase PF09419.10 ORX55616.1 - 4.3e-51 172.9 0.0 5.3e-51 172.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 ORX55616.1 - 9.3e-05 22.4 0.0 0.00017 21.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX55616.1 - 0.02 15.2 0.0 1.5 9.0 0.0 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase Caf4 PF11615.8 ORX55616.1 - 0.033 14.1 0.1 0.29 11.1 0.0 2.0 2 0 0 2 2 2 0 CCR4-associated factor 4 GDP_Man_Dehyd PF16363.5 ORX55617.1 - 5.2e-73 246.3 0.0 6e-73 246.1 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX55617.1 - 3.6e-57 193.6 0.1 4.3e-57 193.3 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX55617.1 - 1.6e-25 89.7 0.0 2.2e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ORX55617.1 - 2.4e-21 76.1 0.2 7.9e-20 71.1 0.2 2.4 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ORX55617.1 - 1.5e-20 73.5 0.0 2e-19 69.8 0.0 2.3 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX55617.1 - 1.3e-16 60.5 0.0 1.7e-16 60.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 ORX55617.1 - 6.3e-08 32.7 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX55617.1 - 0.0011 18.6 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ORX55617.1 - 0.0082 15.6 0.0 0.015 14.7 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase RibD_C PF01872.17 ORX55617.1 - 0.011 15.6 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 RibD C-terminal domain Arrestin_N PF00339.29 ORX55618.1 - 0.00038 20.5 0.1 0.0018 18.3 0.1 2.1 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Methyltransf_16 PF10294.9 ORX55620.1 - 2.5e-08 33.9 0.0 0.0013 18.5 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 ORX55620.1 - 1.4e-06 28.3 0.0 2.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX55620.1 - 0.0012 18.7 0.0 0.24 11.2 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ORX55620.1 - 0.013 16.2 0.0 1.4 9.6 0.0 3.0 3 0 0 3 3 3 0 Methyltransferase domain MTS PF05175.14 ORX55620.1 - 0.02 14.4 0.1 0.071 12.7 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase small domain TehB PF03848.14 ORX55620.1 - 0.049 13.0 0.1 0.27 10.6 0.0 2.2 3 0 0 3 3 3 0 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 ORX55620.1 - 0.12 13.1 0.3 2.9 8.7 0.0 2.9 2 2 1 3 3 3 0 Methyltransferase domain XPA_C PF05181.12 ORX55622.1 - 1.1e-23 82.9 0.9 2.1e-23 82.0 0.9 1.4 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 ORX55622.1 - 0.0021 18.0 2.0 0.0021 18.0 2.0 1.9 2 0 0 2 2 2 1 XPA protein N-terminal RNA_POL_M_15KD PF02150.16 ORX55622.1 - 1.6 8.7 4.7 8.9 6.3 0.1 3.5 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit DUF3027 PF11228.8 ORX55622.1 - 2.3 8.2 5.2 0.86 9.6 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3027) SET PF00856.28 ORX55622.1 - 8.3 6.8 8.7 16 5.9 1.5 2.2 1 1 1 2 2 2 0 SET domain GMP_synt_C PF00958.22 ORX55623.1 - 4e-42 142.2 0.1 7.5e-42 141.3 0.1 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 ORX55623.1 - 5.9e-39 133.8 0.0 1e-38 133.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX55623.1 - 9.7e-14 51.6 0.1 2e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 ORX55623.1 - 2.5e-07 30.1 0.1 2.9e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 NAD synthase tRNA_Me_trans PF03054.16 ORX55623.1 - 0.0022 16.8 0.1 0.0048 15.7 0.1 1.6 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 ORX55623.1 - 0.026 14.0 0.0 0.3 10.5 0.0 2.2 1 1 0 1 1 1 0 Queuosine biosynthesis protein QueC ThiI PF02568.14 ORX55623.1 - 0.046 13.3 0.1 0.094 12.3 0.1 1.5 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) HOASN PF14515.6 ORX55623.1 - 0.074 13.4 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Haem-oxygenase-associated N-terminal helices PAPS_reduct PF01507.19 ORX55623.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family FYDLN_acid PF09538.10 ORX55624.1 - 0.13 13.0 3.5 0.25 12.0 3.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Ank_2 PF12796.7 ORX55625.1 - 1.4e-10 41.6 0.1 5.8e-10 39.6 0.1 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX55625.1 - 5.4e-08 32.9 0.4 0.00021 21.5 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX55625.1 - 1.4e-07 31.2 0.2 0.002 18.4 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ORX55625.1 - 4.4e-07 30.3 0.9 3.7e-05 24.2 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX55625.1 - 4.6e-07 30.0 0.3 0.0028 18.0 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat zf-MYND PF01753.18 ORX55627.1 - 7.4e-05 22.8 9.6 7.4e-05 22.8 9.6 2.0 2 0 0 2 2 2 1 MYND finger TPR_2 PF07719.17 ORX55627.1 - 0.033 14.3 0.9 0.071 13.3 0.9 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-HIT PF04438.16 ORX55627.1 - 2.9 7.8 12.8 0.92 9.4 8.9 2.2 2 0 0 2 2 2 0 HIT zinc finger VATC PF18716.1 ORX55627.1 - 5.2 7.0 9.6 1.5 8.7 5.1 2.2 2 0 0 2 2 2 0 Vms1-associating treble clef domain Actin PF00022.19 ORX55628.1 - 4.2e-51 173.8 0.0 9.9e-49 166.0 0.0 2.1 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 ORX55628.1 - 3.2e-12 45.9 0.0 7.9e-08 31.5 0.0 2.3 2 1 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 ORX55628.1 - 0.00047 20.5 0.1 0.014 15.8 0.0 2.3 2 1 0 2 2 2 1 Cell division protein FtsA RhoGAP PF00620.27 ORX55629.1 - 1e-07 31.9 0.0 2.7e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 ORX55629.1 - 1.3e-06 28.1 0.0 2e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PRP38_assoc PF12871.7 ORX55630.1 - 0.037 14.6 38.8 0.052 14.2 38.8 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Trypan_PARP PF05887.11 ORX55630.1 - 0.042 13.8 7.3 0.05 13.6 7.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Herpes_env PF01673.18 ORX55630.1 - 0.3 9.9 1.5 0.31 9.9 1.5 1.0 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein Atrophin-1 PF03154.15 ORX55630.1 - 0.32 9.2 53.7 0.026 12.9 31.9 2.0 1 1 1 2 2 2 0 Atrophin-1 family DUF2058 PF09831.9 ORX55630.1 - 0.64 10.2 16.1 0.73 10.0 16.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) AAA_11 PF13086.6 ORX55630.1 - 0.73 9.6 7.4 0.75 9.5 7.4 1.0 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ORX55630.1 - 0.78 8.4 6.9 0.87 8.3 6.9 1.0 1 0 0 1 1 1 0 Presenilin Ycf1 PF05758.12 ORX55630.1 - 0.95 7.2 6.8 1.1 7.0 6.8 1.1 1 0 0 1 1 1 0 Ycf1 Connexin PF00029.19 ORX55630.1 - 1.1 9.0 8.3 1.1 9.0 8.3 1.1 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 ORX55630.1 - 1.8 9.0 5.5 2.2 8.8 5.5 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MDM10 PF12519.8 ORX55630.1 - 3.6 6.4 4.9 4.1 6.1 4.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2828 PF11443.8 ORX55630.1 - 6.3 4.8 12.3 7.1 4.6 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) V_ATPase_I PF01496.19 ORX55630.1 - 6.4 4.6 6.8 7.4 4.3 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ORX55630.1 - 7 5.3 12.2 8.2 5.1 12.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_L33 PF00471.20 ORX55631.1 - 1.6e-09 38.0 0.0 2.1e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L33 zf-C2H2 PF00096.26 ORX55632.1 - 1.6e-09 37.7 14.0 6.7e-05 23.1 0.7 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX55632.1 - 1.1e-07 32.0 10.2 0.00021 21.6 0.4 4.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX55632.1 - 0.00062 20.4 7.4 0.0069 17.1 1.0 3.8 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 ORX55632.1 - 0.0022 18.2 0.3 0.0058 16.9 0.3 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ORX55632.1 - 0.035 14.1 0.4 0.035 14.1 0.4 4.1 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX55632.1 - 0.039 14.3 1.9 0.28 11.5 0.1 2.8 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX55632.1 - 0.12 12.8 2.0 1.1 9.8 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 ORX55632.1 - 0.76 9.7 3.1 4.5 7.3 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 ORX55632.1 - 7 6.5 7.3 0.87 9.4 1.5 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF1681 PF07933.14 ORX55634.1 - 8.8e-59 197.5 0.0 1.1e-58 197.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) AMMECR1 PF01871.17 ORX55635.1 - 6.3e-47 159.3 0.0 7.3e-47 159.1 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 GDA1_CD39 PF01150.17 ORX55636.1 - 9.1e-99 331.0 0.0 1e-98 330.8 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Pkinase PF00069.25 ORX55637.1 - 2.7e-57 194.1 0.0 3.4e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX55637.1 - 8.1e-23 81.0 0.0 1.1e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX55637.1 - 0.0024 17.2 0.0 0.005 16.2 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX55637.1 - 0.0047 16.9 0.0 0.007 16.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX55637.1 - 0.0054 16.4 0.2 0.0079 15.8 0.2 1.2 1 0 0 1 1 1 1 Choline/ethanolamine kinase Kdo PF06293.14 ORX55637.1 - 0.035 13.5 0.0 0.055 12.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Glyco_hydro_88 PF07470.13 ORX55637.1 - 0.071 12.2 0.2 0.096 11.7 0.2 1.1 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 NIF PF03031.18 ORX55638.1 - 5.3e-24 84.8 0.0 6.1e-24 84.6 0.0 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Polysacc_lyase PF14099.6 ORX55639.1 - 0.00068 19.6 0.4 0.0013 18.6 0.2 1.5 1 1 0 1 1 1 1 Polysaccharide lyase GRIM-19 PF06212.12 ORX55640.1 - 3.3e-30 104.7 0.0 4.3e-30 104.4 0.0 1.0 1 0 0 1 1 1 1 GRIM-19 protein WD40 PF00400.32 ORX55641.1 - 8.7e-39 130.8 22.2 5.6e-07 30.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX55641.1 - 3.9e-15 55.9 0.0 0.038 14.3 0.0 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX55641.1 - 0.0019 18.1 0.0 0.91 9.4 0.0 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ORX55641.1 - 0.012 14.9 0.0 5.1 6.3 0.0 3.5 3 1 0 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 ORX55641.1 - 0.019 13.9 0.3 35 3.2 0.1 4.1 3 2 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1325 PF07039.11 ORX55642.1 - 1.1e-25 90.3 0.9 3.1e-23 82.3 0.9 2.3 1 1 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 ORX55642.1 - 7.4e-05 22.5 0.0 0.00022 21.0 0.0 1.8 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain LBR_tudor PF09465.10 ORX55642.1 - 0.032 14.0 0.0 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 Lamin-B receptor of TUDOR domain FXR_C3 PF16097.5 ORX55642.1 - 0.035 14.8 1.9 0.1 13.3 1.9 1.8 1 0 0 1 1 1 0 Fragile X-related 1 protein C-terminal region 3 CotH PF08757.11 ORX55643.1 - 6e-29 101.6 1.0 8.5e-29 101.1 1.0 1.1 1 0 0 1 1 1 1 CotH kinase protein PINIT PF14324.6 ORX55644.1 - 1e-29 103.7 1.0 1.9e-29 102.9 1.0 1.4 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 ORX55644.1 - 1.9e-21 75.5 2.9 4e-21 74.5 2.9 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 ORX55644.1 - 2.3e-08 33.7 1.9 2.3e-08 33.7 1.9 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit Exo_endo_phos_2 PF14529.6 ORX55644.1 - 0.036 13.9 1.3 0.11 12.4 0.2 2.3 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase WWE PF02825.20 ORX55645.1 - 2.2e-07 31.4 1.6 0.00025 21.6 0.1 2.5 1 1 1 2 2 2 2 WWE domain DDHD PF02862.17 ORX55646.1 - 4.7e-45 154.5 0.0 1.9e-44 152.5 0.0 1.9 2 0 0 2 2 2 1 DDHD domain Complex1_LYR_2 PF13233.6 ORX55647.1 - 6.8e-10 39.6 1.7 9.6e-10 39.1 1.7 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 ORX55647.1 - 1.3e-05 25.2 0.1 2.4e-05 24.3 0.1 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Myb_DNA-bind_5 PF13873.6 ORX55647.1 - 0.11 12.6 1.9 0.66 10.1 0.7 2.2 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain PSP1 PF04468.12 ORX55647.1 - 0.13 12.6 1.5 3.5 8.0 0.2 2.2 1 1 0 2 2 2 0 PSP1 C-terminal conserved region Ndc1_Nup PF09531.10 ORX55649.1 - 1.6e-43 149.4 9.0 2.2e-43 148.9 9.0 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Potass_KdpF PF09604.10 ORX55649.1 - 3.3 7.8 5.6 1.4 9.0 0.0 2.4 2 0 0 2 2 2 0 F subunit of K+-transporting ATPase (Potass_KdpF) Ribosomal_L35Ae PF01247.18 ORX55650.1 - 9.4e-43 144.3 0.9 1.1e-42 144.1 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 ORX55650.1 - 0.00058 20.0 0.0 0.095 12.9 0.0 2.1 2 0 0 2 2 2 2 RimM N-terminal domain NifU_N PF01592.16 ORX55651.1 - 7.3e-56 187.8 0.1 8.4e-56 187.6 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DDE_Tnp_IS1 PF03400.13 ORX55651.1 - 0.15 12.4 0.1 0.22 11.9 0.1 1.3 1 0 0 1 1 1 0 IS1 transposase CRT-like PF08627.10 ORX55652.1 - 2.9e-11 42.9 11.9 6.7e-11 41.7 2.2 2.2 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like Nuc_sug_transp PF04142.15 ORX55652.1 - 6.9e-06 25.5 0.2 1.4e-05 24.5 0.2 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ORX55652.1 - 0.0013 18.9 3.3 0.0013 18.9 3.3 2.8 2 1 0 2 2 2 1 EamA-like transporter family PUNUT PF16913.5 ORX55652.1 - 0.0095 15.2 8.0 0.016 14.4 7.8 1.8 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport TPT PF03151.16 ORX55652.1 - 0.052 12.9 7.2 0.11 11.8 7.2 1.6 1 1 0 1 1 1 0 Triose-phosphate Transporter family DUF4231 PF14015.6 ORX55652.1 - 6.4 7.3 7.2 4.5 7.8 0.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4231) COQ9 PF08511.11 ORX55654.1 - 2.1e-29 101.1 0.7 3.9e-29 100.3 0.3 1.7 2 0 0 2 2 2 1 COQ9 HTH_1 PF00126.27 ORX55654.1 - 0.05 13.6 0.1 13 5.8 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Ribosomal_L18 PF17135.4 ORX55655.1 - 1.3e-90 301.9 5.6 1.4e-90 301.7 5.6 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 ORX55655.1 - 0.0019 18.9 0.3 0.0069 17.1 0.3 2.0 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A AMP-binding PF00501.28 ORX55656.1 - 3.4e-53 180.8 0.0 4.9e-53 180.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX55656.1 - 1.7e-17 64.2 0.6 2.3e-07 31.7 0.1 2.6 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain Hexapep PF00132.24 ORX55656.1 - 3.7e-07 29.6 8.8 0.0035 17.0 0.0 5.8 4 1 2 6 6 6 2 Bacterial transferase hexapeptide (six repeats) PP-binding PF00550.25 ORX55656.1 - 0.00038 20.8 0.0 0.0011 19.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Hexapep_2 PF14602.6 ORX55656.1 - 0.0064 16.2 16.8 0.39 10.5 0.1 5.3 5 1 0 5 5 5 3 Hexapeptide repeat of succinyl-transferase Baculo_11_kDa PF06143.11 ORX55656.1 - 0.035 13.7 0.0 0.11 12.1 0.0 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family GH3 PF03321.13 ORX55656.1 - 0.036 12.9 0.0 0.076 11.9 0.0 1.4 1 0 0 1 1 1 0 GH3 auxin-responsive promoter TPR_1 PF00515.28 ORX55657.1 - 4.8e-41 137.0 16.5 0.00034 20.3 0.3 11.2 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 ORX55657.1 - 1.1e-37 125.1 8.6 0.00029 20.7 0.1 11.3 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_11 PF13414.6 ORX55657.1 - 1.4e-30 104.7 18.2 8.1e-07 28.6 0.0 9.2 6 2 4 10 10 10 6 TPR repeat TPR_8 PF13181.6 ORX55657.1 - 5.6e-25 85.4 19.3 0.00091 19.3 0.0 11.0 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_17 PF13431.6 ORX55657.1 - 1.8e-24 84.3 4.8 0.00096 19.4 0.1 8.7 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 ORX55657.1 - 1.3e-20 73.7 2.8 0.0027 18.3 0.0 6.6 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX55657.1 - 1.1e-19 70.7 8.0 0.00043 20.7 0.9 7.8 4 2 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX55657.1 - 2.4e-18 65.2 2.0 0.042 14.7 0.4 9.2 3 1 7 10 10 10 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55657.1 - 5.3e-15 55.5 13.1 0.00083 19.6 1.1 7.6 4 3 4 8 8 8 6 Tetratricopeptide repeat TPR_9 PF13371.6 ORX55657.1 - 1.9e-14 53.5 0.0 1.2e-05 25.4 0.0 5.6 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX55657.1 - 3.2e-07 30.5 18.7 0.035 14.8 0.0 8.8 11 0 0 11 11 9 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX55657.1 - 2.7e-06 27.5 5.6 4.3 7.6 0.0 5.8 2 2 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX55657.1 - 3.7e-06 26.6 11.4 0.022 14.8 0.2 7.9 10 0 0 10 10 8 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX55657.1 - 5.5e-06 25.6 1.0 0.003 16.5 0.0 5.1 2 2 4 6 6 5 4 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 ORX55657.1 - 7e-06 25.6 0.1 0.0087 15.5 0.2 3.1 2 1 0 3 3 3 2 MalT-like TPR region TPR_15 PF13429.6 ORX55657.1 - 2.1e-05 23.9 0.1 3 7.0 0.0 4.5 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX55657.1 - 0.00017 21.9 2.3 7.6 6.9 0.0 5.4 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX55657.1 - 0.0012 18.6 10.8 2.4 8.2 0.2 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat DUF4810 PF16068.5 ORX55657.1 - 0.0015 19.0 0.1 2 9.0 0.0 3.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4810) TPR_4 PF07721.14 ORX55657.1 - 0.002 18.5 0.3 0.48 11.2 0.1 3.7 2 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ORX55657.1 - 0.0064 16.5 17.1 1.7 8.7 0.1 7.7 7 1 0 7 7 7 1 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 ORX55657.1 - 0.016 15.3 2.1 37 4.4 0.1 4.6 5 1 0 5 5 5 0 Domain of Unknown Function (DUF3856) CDC37_M PF08565.11 ORX55657.1 - 0.03 14.2 0.1 21 5.0 0.0 3.3 3 0 0 3 3 3 0 Cdc37 Hsp90 binding domain TPR_3 PF07720.12 ORX55657.1 - 2.6 8.1 15.1 1.4 8.9 0.1 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ORX55657.1 - 5.6 6.6 7.9 26 4.5 0.0 4.2 5 0 0 5 5 5 0 Helix-turn-helix bacterial domain AAA_2 PF07724.14 ORX55658.1 - 1e-54 185.2 0.5 4.6e-50 170.1 0.0 3.1 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 ORX55658.1 - 2.8e-34 117.2 1.2 2.8e-34 117.2 1.2 3.5 2 1 1 3 3 3 1 AAA lid domain AAA PF00004.29 ORX55658.1 - 4.6e-28 98.3 0.4 1.3e-14 54.8 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 ORX55658.1 - 5.8e-25 87.2 0.0 3.2e-24 84.8 0.0 2.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein Clp_N PF02861.20 ORX55658.1 - 2.7e-21 75.4 0.1 4.4e-11 42.7 0.0 2.9 2 0 0 2 2 2 2 Clp amino terminal domain, pathogenicity island component AAA_5 PF07728.14 ORX55658.1 - 1.3e-19 70.6 1.1 1.8e-10 41.0 0.0 4.2 4 1 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ORX55658.1 - 5.9e-12 46.3 5.8 1.5e-07 32.0 0.0 4.7 4 2 0 5 5 3 2 AAA ATPase domain Sigma54_activat PF00158.26 ORX55658.1 - 2e-10 40.6 0.1 2.2e-06 27.5 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_22 PF13401.6 ORX55658.1 - 1.9e-09 37.9 3.8 0.0088 16.3 0.0 4.9 4 2 0 4 4 3 2 AAA domain TniB PF05621.11 ORX55658.1 - 1.7e-08 34.1 0.5 0.00012 21.5 0.0 4.1 3 1 0 3 3 3 1 Bacterial TniB protein AAA_7 PF12775.7 ORX55658.1 - 4.2e-08 32.9 0.0 0.00043 19.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region IstB_IS21 PF01695.17 ORX55658.1 - 1.5e-07 31.3 0.0 0.026 14.2 0.0 2.9 2 1 0 2 2 2 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 ORX55658.1 - 7.2e-07 28.8 0.1 0.029 13.7 0.1 3.7 3 1 0 3 3 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ORX55658.1 - 1.4e-06 28.3 0.0 0.02 14.9 0.0 3.3 2 0 0 2 2 2 2 AAA domain DUF815 PF05673.13 ORX55658.1 - 1.7e-05 24.1 1.2 0.089 11.9 0.4 3.4 2 2 0 2 2 2 2 Protein of unknown function (DUF815) Roc PF08477.13 ORX55658.1 - 3.2e-05 24.1 0.0 0.11 12.8 0.0 3.2 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ORX55658.1 - 0.00013 21.9 0.0 0.04 13.8 0.0 2.9 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 ORX55658.1 - 0.00017 21.9 0.0 1.1 9.7 0.0 2.9 3 0 0 3 3 2 2 RNA helicase BLOC1_2 PF10046.9 ORX55658.1 - 0.00018 21.7 2.2 0.00078 19.7 2.2 2.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Torsin PF06309.11 ORX55658.1 - 0.00028 21.0 0.0 0.00076 19.6 0.0 1.7 1 0 0 1 1 1 1 Torsin AAA_18 PF13238.6 ORX55658.1 - 0.00054 20.5 3.5 0.19 12.3 0.0 3.4 3 1 0 3 3 2 1 AAA domain ATPase_2 PF01637.18 ORX55658.1 - 0.00063 19.7 5.2 1.2 9.0 0.0 4.7 3 2 1 5 5 4 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 ORX55658.1 - 0.00069 19.9 0.1 5.9 7.1 0.0 3.8 3 0 0 3 3 3 0 AAA domain ResIII PF04851.15 ORX55658.1 - 0.00072 19.6 0.0 0.046 13.7 0.0 3.2 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit FTA4 PF13093.6 ORX55658.1 - 0.00089 19.2 4.3 0.0025 17.7 4.3 1.8 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 AAA_24 PF13479.6 ORX55658.1 - 0.001 18.8 0.0 0.61 9.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ORX55658.1 - 0.0013 18.5 3.0 2.7 7.7 0.4 3.8 3 1 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 ORX55658.1 - 0.0015 18.6 0.0 0.99 9.4 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ORX55658.1 - 0.002 18.6 0.7 0.57 10.7 0.0 3.5 4 0 0 4 4 3 1 ABC transporter AAA_30 PF13604.6 ORX55658.1 - 0.0035 17.1 0.0 1.5 8.5 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_3 PF07726.11 ORX55658.1 - 0.0089 15.9 0.0 3.2 7.6 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 ORX55658.1 - 0.0093 16.3 0.7 0.3 11.4 0.1 3.1 3 1 0 3 3 2 1 AAA domain PduV-EutP PF10662.9 ORX55658.1 - 0.01 15.6 0.0 0.84 9.4 0.0 3.1 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation DASH_Spc19 PF08287.11 ORX55658.1 - 0.013 15.3 10.9 0.036 13.9 10.9 1.7 1 0 0 1 1 1 0 Spc19 AAA_33 PF13671.6 ORX55658.1 - 0.014 15.6 0.0 6.9 6.8 0.0 3.1 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ORX55658.1 - 0.015 15.0 0.0 1.9 8.0 0.0 3.1 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain SKA2 PF16740.5 ORX55658.1 - 0.018 14.8 5.1 0.081 12.7 5.1 2.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 LOH1CR12 PF10158.9 ORX55658.1 - 0.02 14.9 0.3 0.078 13.0 0.4 2.0 2 0 0 2 2 1 0 Tumour suppressor protein Med30 PF11315.8 ORX55658.1 - 0.032 14.4 4.6 0.12 12.6 4.6 1.9 1 0 0 1 1 1 0 Mediator complex subunit 30 RsgA_GTPase PF03193.16 ORX55658.1 - 0.039 13.9 0.0 4.6 7.1 0.0 2.9 2 0 0 2 2 2 0 RsgA GTPase AAA_25 PF13481.6 ORX55658.1 - 0.042 13.4 1.5 5.3 6.6 0.0 3.7 3 1 0 3 3 3 0 AAA domain KELK PF15796.5 ORX55658.1 - 0.047 14.2 14.1 0.36 11.3 12.2 3.2 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase tRNA-synt_His PF13393.6 ORX55658.1 - 0.05 12.9 3.8 0.14 11.4 3.8 1.8 1 0 0 1 1 1 0 Histidyl-tRNA synthetase NTPase_1 PF03266.15 ORX55658.1 - 0.06 13.3 0.1 3 7.7 0.0 3.2 3 0 0 3 3 3 0 NTPase DUF5082 PF16888.5 ORX55658.1 - 0.11 12.8 7.2 8.2 6.7 0.1 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) APG6_N PF17675.1 ORX55658.1 - 0.15 12.6 14.3 0.54 10.8 14.3 1.9 1 0 0 1 1 1 0 Apg6 coiled-coil region DHR10 PF18595.1 ORX55658.1 - 0.16 12.0 15.8 0.071 13.2 12.4 2.2 2 0 0 2 2 1 0 Designed helical repeat protein 10 domain Prefoldin PF02996.17 ORX55658.1 - 0.3 11.0 5.8 2.2 8.2 2.3 3.2 2 0 0 2 2 2 0 Prefoldin subunit Spc7 PF08317.11 ORX55658.1 - 0.51 9.2 10.6 1.1 8.1 10.6 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Hemerythrin PF01814.23 ORX55658.1 - 0.52 10.9 3.5 34 5.1 0.2 3.6 3 0 0 3 3 3 0 Hemerythrin HHE cation binding domain AAA_23 PF13476.6 ORX55658.1 - 0.7 10.4 19.4 13 6.2 0.0 4.5 3 1 0 3 3 2 0 AAA domain DUF4795 PF16043.5 ORX55658.1 - 2.4 7.7 12.8 0.22 11.1 6.9 2.3 3 0 0 3 3 2 0 Domain of unknown function (DUF4795) DUF4407 PF14362.6 ORX55658.1 - 2.5 7.4 8.1 4.8 6.4 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 ORX55658.1 - 4.8 7.2 11.2 7.4 6.6 9.8 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ORX55658.1 - 5.5 4.8 9.4 0.5 8.2 4.5 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 ORX55658.1 - 7.1 6.5 8.0 33 4.3 8.0 2.2 1 1 0 1 1 1 0 Septum formation initiator Tup_N PF08581.10 ORX55658.1 - 7.6 6.9 11.5 1.2 9.5 4.9 3.1 3 1 1 4 4 2 0 Tup N-terminal SURF6 PF04935.12 ORX55659.1 - 0.0015 18.3 3.4 0.003 17.4 3.4 1.4 1 0 0 1 1 1 1 Surfeit locus protein 6 FAM220 PF15487.6 ORX55659.1 - 0.062 12.9 1.1 0.095 12.3 1.1 1.3 1 0 0 1 1 1 0 FAM220 family DUF3827 PF12877.7 ORX55659.1 - 0.16 10.3 6.9 0.23 9.8 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Presenilin PF01080.17 ORX55659.1 - 0.3 9.8 1.7 0.43 9.3 1.7 1.2 1 0 0 1 1 1 0 Presenilin FAM199X PF15814.5 ORX55659.1 - 0.37 9.8 4.0 0.76 8.8 4.0 1.4 1 0 0 1 1 1 0 Protein family FAM199X NPR3 PF03666.13 ORX55659.1 - 1.1 7.9 5.2 1.9 7.2 5.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2956 PF11169.8 ORX55659.1 - 2.4 8.4 8.0 0.081 13.1 0.8 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) CCDC53 PF10152.9 ORX55659.1 - 4.3 7.7 7.5 1.8 9.0 4.4 1.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex MAS20 PF02064.15 ORX55659.1 - 7.2 6.7 7.4 19 5.3 7.4 1.7 1 0 0 1 1 1 0 MAS20 protein import receptor FGGY_N PF00370.21 ORX55660.1 - 1.3e-75 254.1 0.0 1.9e-75 253.6 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FGGY_C PF02782.16 ORX55660.1 - 1.6e-61 207.5 0.3 1.6e-61 207.5 0.3 1.5 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Zn_clus PF00172.18 ORX55661.1 - 0.0019 18.3 13.9 0.0049 17.0 13.9 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DPBB_1 PF03330.18 ORX55662.1 - 1.7e-10 41.0 0.1 3.6e-10 40.0 0.1 1.6 1 1 0 1 1 1 1 Lytic transglycolase RINGv PF12906.7 ORX55663.1 - 3.2e-13 49.6 12.3 1.4e-12 47.5 12.3 2.2 1 0 0 1 1 1 1 RING-variant domain RhoGEF PF00621.20 ORX55664.1 - 2.2e-33 116.0 2.2 3.4e-33 115.4 2.2 1.3 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ORX55664.1 - 0.0025 18.3 0.0 0.0062 17.0 0.0 1.6 2 0 0 2 2 2 1 PH domain Peptidase_M50B PF13398.6 ORX55665.1 - 0.072 12.7 4.4 0.092 12.4 4.4 1.1 1 0 0 1 1 1 0 Peptidase M50B-like Abhydrolase_3 PF07859.13 ORX55667.1 - 7.7e-34 117.4 0.1 1e-33 117.0 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX55667.1 - 2.8e-22 79.1 0.0 3.4e-22 78.8 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX55667.1 - 0.00059 19.4 0.0 0.0067 15.9 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family DUF2974 PF11187.8 ORX55667.1 - 0.04 13.5 0.0 0.076 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) COesterase PF00135.28 ORX55667.1 - 0.051 12.4 0.1 3.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Peptidase_M16_C PF05193.21 ORX55668.1 - 1e-19 71.3 0.0 1.6e-15 57.6 0.0 2.7 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX55668.1 - 1.8e-09 37.7 3.2 8.4e-06 25.8 0.0 3.1 4 0 0 4 4 4 2 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 ORX55668.1 - 0.005 16.0 4.0 0.029 13.5 1.4 2.9 2 1 0 2 2 2 1 Peptidase M16C associated Tctex-1 PF03645.13 ORX55669.1 - 1.8e-28 98.8 1.5 2.1e-28 98.6 1.5 1.0 1 0 0 1 1 1 1 Tctex-1 family LPD29 PF18847.1 ORX55669.1 - 0.11 13.5 0.5 0.25 12.3 0.2 1.8 1 1 1 2 2 2 0 Large polyvalent protein associated domain 29 PQ-loop PF04193.14 ORX55670.1 - 5.6e-14 51.6 11.0 2.3e-09 36.9 0.1 2.8 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 ORX55670.1 - 0.016 16.0 5.3 0.085 13.7 4.2 2.4 1 1 1 2 2 2 0 ER lumen protein retaining receptor MtN3_slv PF03083.16 ORX55670.1 - 0.4 10.7 0.1 0.4 10.7 0.1 3.1 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange DUF3712 PF12505.8 ORX55671.1 - 2.9e-60 202.0 55.2 3e-20 72.7 1.4 7.8 7 0 0 7 7 7 4 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ORX55671.1 - 3.6e-06 27.4 17.9 0.49 11.0 0.2 7.3 8 1 0 8 8 8 3 Late embryogenesis abundant protein YceI PF04264.13 ORX55671.1 - 0.36 11.4 4.8 12 6.4 0.7 3.2 2 0 0 2 2 2 0 YceI-like domain Shisa PF13908.6 ORX55671.1 - 3.4 7.9 7.9 0.19 12.0 0.1 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator COX15-CtaA PF02628.15 ORX55672.1 - 2e-105 352.4 4.3 2.4e-105 352.2 4.3 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Myb_DNA-bind_7 PF15963.5 ORX55673.1 - 5.2e-25 87.2 1.4 5.2e-25 87.2 1.4 2.6 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 ORX55673.1 - 7.3e-06 26.1 0.0 1.5e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX55673.1 - 0.0005 20.3 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Diphthamide_syn PF01866.17 ORX55674.1 - 2.6e-117 391.6 0.0 3.3e-117 391.3 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein tRNA-synt_1b PF00579.25 ORX55675.1 - 6.1e-64 216.1 0.0 8e-64 215.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF92 PF01940.16 ORX55677.1 - 0.0047 16.4 0.1 0.0047 16.4 0.1 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 DIL PF01843.19 ORX55678.1 - 5.8e-19 68.3 1.3 5.8e-19 68.3 1.3 2.4 3 0 0 3 3 3 1 DIL domain Ank_2 PF12796.7 ORX55678.1 - 1.4e-07 31.9 0.1 4.4e-07 30.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX55678.1 - 0.00025 21.3 0.0 0.12 12.9 0.0 3.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ORX55678.1 - 0.0021 18.6 0.0 0.007 16.9 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX55678.1 - 0.0037 17.5 0.0 0.0092 16.3 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX55678.1 - 0.011 16.2 0.0 2.6 8.9 0.0 3.3 2 0 0 2 2 2 0 Ankyrin repeat HSF_DNA-bind PF00447.17 ORX55679.1 - 7.8e-17 61.7 0.1 1.3e-16 61.0 0.1 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding STE PF02200.16 ORX55680.1 - 0.028 14.8 0.7 0.087 13.3 0.7 1.7 1 1 0 1 1 1 0 STE like transcription factor Na_H_Exchanger PF00999.21 ORX55681.1 - 3e-70 236.9 36.6 3.6e-70 236.7 36.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Tim17 PF02466.19 ORX55681.1 - 0.049 14.0 4.1 0.54 10.6 0.0 3.5 4 0 0 4 4 4 0 Tim17/Tim22/Tim23/Pmp24 family PNISR PF15996.5 ORX55681.1 - 8.6 6.6 8.5 21 5.3 5.4 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Clathrin_lg_ch PF01086.17 ORX55682.1 - 8.1e-35 120.9 11.5 1.5e-34 120.0 11.5 1.4 1 1 0 1 1 1 1 Clathrin light chain DUF4659 PF15558.6 ORX55682.1 - 0.0038 16.1 7.2 0.005 15.8 7.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4659) RPN7 PF10602.9 ORX55682.1 - 0.0044 16.7 2.6 0.0061 16.3 2.6 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 DUF1778 PF08681.11 ORX55682.1 - 0.018 14.9 0.7 0.031 14.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1778) Mitofilin PF09731.9 ORX55682.1 - 0.021 13.7 7.2 0.024 13.5 7.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein MIP-T3_C PF17749.1 ORX55682.1 - 0.058 13.4 0.6 0.058 13.4 0.6 2.4 2 1 1 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region ARGLU PF15346.6 ORX55682.1 - 0.099 12.5 10.9 0.14 12.0 10.9 1.2 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 CdiI_2 PF18593.1 ORX55682.1 - 0.14 12.9 1.6 27 5.5 0.4 2.9 2 1 0 3 3 3 0 CdiI immunity protein CENP-K PF11802.8 ORX55682.1 - 0.2 11.2 7.3 0.29 10.6 7.3 1.1 1 0 0 1 1 1 0 Centromere-associated protein K DUF4200 PF13863.6 ORX55682.1 - 2.3 8.7 15.9 6.1 7.3 15.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) OmpH PF03938.14 ORX55682.1 - 2.5 8.4 14.1 4.2 7.7 14.1 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Endonuc_Holl PF10107.9 ORX55682.1 - 2.7 7.8 7.0 3.8 7.4 7.0 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase SET PF00856.28 ORX55683.1 - 0.017 15.5 0.0 0.038 14.4 0.0 1.7 1 1 0 1 1 1 0 SET domain PRP38 PF03371.15 ORX55684.1 - 4.8e-50 169.8 1.1 5.6e-50 169.6 1.1 1.0 1 0 0 1 1 1 1 PRP38 family FMN_red PF03358.15 ORX55685.1 - 2.3e-10 40.4 0.0 3.7e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX55685.1 - 0.0016 18.2 0.0 0.0021 17.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold FAD_binding_3 PF01494.19 ORX55687.1 - 9.9e-16 57.9 0.3 1.2e-09 37.9 0.1 2.7 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 ORX55687.1 - 0.0023 18.1 0.0 0.0068 16.6 0.0 2.0 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX55687.1 - 0.14 11.4 0.0 0.24 10.6 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX55687.1 - 0.19 10.4 0.0 0.29 9.8 0.0 1.3 1 0 0 1 1 1 0 HI0933-like protein CNH PF00780.22 ORX55689.1 - 8e-53 179.8 0.0 1.3e-52 179.1 0.0 1.2 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX55689.1 - 2e-38 132.4 2.7 2.2e-38 132.3 1.7 1.6 2 0 0 2 2 2 1 RhoGEF domain PH_5 PF15405.6 ORX55689.1 - 2.8e-18 66.3 0.0 6e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Prefoldin_2 PF01920.20 ORX55690.1 - 0.0024 17.8 6.8 0.0032 17.4 6.5 1.5 1 1 0 1 1 1 1 Prefoldin subunit DUF3106 PF11304.8 ORX55690.1 - 0.016 15.6 1.3 0.016 15.6 1.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3106) zf-C2H2_4 PF13894.6 ORX55691.1 - 5.3e-05 23.7 4.9 0.089 13.7 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX55691.1 - 0.0002 21.6 3.4 0.11 13.0 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 ORX55691.1 - 0.0017 18.6 3.1 0.08 13.2 0.1 2.1 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 ORX55691.1 - 0.0035 17.6 4.9 0.12 12.7 4.4 2.1 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 ORX55691.1 - 0.0085 15.8 0.3 0.019 14.7 0.3 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type ComK PF06338.11 ORX55691.1 - 0.013 15.2 0.3 0.02 14.5 0.3 1.2 1 0 0 1 1 1 0 ComK protein HNH PF01844.23 ORX55691.1 - 0.023 14.9 3.0 0.22 11.7 0.1 2.3 2 0 0 2 2 2 0 HNH endonuclease Sprouty PF05210.13 ORX55691.1 - 0.038 14.4 1.2 2 8.8 0.1 2.1 2 0 0 2 2 2 0 Sprouty protein (Spry) zf-C2H2_jaz PF12171.8 ORX55691.1 - 0.044 14.1 2.4 0.044 14.1 2.4 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Thioredoxin_3 PF13192.6 ORX55691.1 - 0.046 13.8 1.0 1.2 9.3 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin domain zf-C2H2_3rep PF18868.1 ORX55691.1 - 0.066 13.9 2.1 3.1 8.5 0.1 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 ORX55691.1 - 0.097 12.7 8.0 0.66 10.0 0.6 2.7 3 0 0 3 3 3 0 C2H2-type zinc finger DZR PF12773.7 ORX55691.1 - 0.13 12.3 2.3 2.4 8.3 3.0 2.0 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_9 PF16293.5 ORX55691.1 - 0.13 12.2 1.4 0.2 11.5 0.1 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) DUF629 PF04780.12 ORX55691.1 - 0.18 10.3 2.3 2.5 6.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF629) HNH_5 PF14279.6 ORX55691.1 - 1.4 8.8 5.3 1.6 8.6 0.3 2.3 2 0 0 2 2 2 0 HNH endonuclease SWIM PF04434.17 ORX55695.1 - 7e-05 22.4 0.4 0.00017 21.2 0.4 1.7 1 0 0 1 1 1 1 SWIM zinc finger TAF6_C PF07571.13 ORX55696.1 - 5.5e-32 110.0 0.0 1.3e-31 108.8 0.0 1.6 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 ORX55696.1 - 9.9e-27 92.9 0.7 2.2e-26 91.8 0.7 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 ORX55696.1 - 0.00032 20.8 0.1 0.001 19.2 0.1 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 ORX55696.1 - 0.0012 19.2 0.1 0.011 16.1 0.1 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 HEAT_EZ PF13513.6 ORX55696.1 - 0.0087 16.5 0.0 2.5 8.7 0.0 3.5 3 0 0 3 3 3 1 HEAT-like repeat MMS19_C PF12460.8 ORX55696.1 - 0.024 13.8 0.3 0.08 12.0 0.1 1.8 1 1 1 2 2 2 0 RNAPII transcription regulator C-terminal HEAT PF02985.22 ORX55696.1 - 0.067 13.5 0.2 2.7 8.5 0.0 3.3 3 1 0 3 3 3 0 HEAT repeat Mad3_BUB1_II PF08171.11 ORX55696.1 - 0.097 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 Bromo_TP PF07524.13 ORX55696.1 - 0.14 12.2 0.0 2.1 8.4 0.0 2.4 2 0 0 2 2 2 0 Bromodomain associated Cadherin_C_2 PF16492.5 ORX55697.1 - 0.048 14.4 0.6 0.19 12.5 0.6 2.2 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal LRRC37AB_C PF14914.6 ORX55697.1 - 0.069 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain QWRF PF04484.12 ORX55697.1 - 0.65 9.7 7.6 1 9.1 7.6 1.3 1 0 0 1 1 1 0 QWRF family SPX PF03105.19 ORX55697.1 - 0.91 9.4 6.1 0.68 9.8 4.8 1.3 1 1 0 1 1 1 0 SPX domain DUF4686 PF15742.5 ORX55698.1 - 0.067 12.3 0.9 0.072 12.2 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4686) DUF5385 PF17359.2 ORX55698.1 - 0.087 12.4 0.1 0.094 12.3 0.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5385) HOOK PF05622.12 ORX55699.1 - 2.2e-25 89.0 0.1 2.6e-25 88.7 0.1 1.0 1 0 0 1 1 1 1 HOOK protein DUF2742 PF10888.8 ORX55699.1 - 0.012 15.9 0.0 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2742) DUF3369 PF11849.8 ORX55699.1 - 0.1 12.8 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) HOOK PF05622.12 ORX55700.1 - 4.5e-26 91.2 51.0 4.5e-26 91.2 51.0 2.2 2 1 0 2 2 2 1 HOOK protein bZIP_1 PF00170.21 ORX55700.1 - 0.015 15.4 2.9 0.015 15.4 2.9 6.9 6 1 1 7 7 7 0 bZIP transcription factor Alg14 PF08660.11 ORX55700.1 - 2.2 8.2 4.0 0.93 9.4 0.1 2.3 3 0 0 3 3 3 0 Oligosaccharide biosynthesis protein Alg14 like Ribosomal_L39 PF00832.20 ORX55701.1 - 8.1e-20 70.2 11.7 9.2e-20 70.0 11.7 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein RhoGEF PF00621.20 ORX55702.1 - 1.1e-49 169.2 1.0 1.1e-49 169.2 1.0 3.1 3 2 0 3 3 3 1 RhoGEF domain SH3_9 PF14604.6 ORX55702.1 - 3.1e-20 71.8 4.8 9.6e-10 38.2 1.2 2.7 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX55702.1 - 2.5e-18 65.4 2.6 1.7e-08 33.9 0.7 2.7 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ORX55702.1 - 3.5e-12 45.8 0.0 2.4e-05 23.9 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PH_13 PF16652.5 ORX55702.1 - 2.2e-10 40.6 0.0 2.2e-10 40.6 0.0 3.4 2 1 1 3 3 3 1 Pleckstrin homology domain DUF3712 PF12505.8 ORX55704.1 - 1.5e-59 199.7 55.3 7e-21 74.8 2.1 7.1 7 0 0 7 7 7 5 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ORX55704.1 - 2.6e-09 37.5 17.9 0.26 11.8 0.1 9.0 9 1 1 10 10 10 3 Late embryogenesis abundant protein Caveolin PF01146.17 ORX55704.1 - 1 9.4 3.4 2.1 8.3 3.4 1.5 1 0 0 1 1 1 0 Caveolin Shisa PF13908.6 ORX55704.1 - 6.3 7.0 5.1 1.4 9.2 0.0 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Spermine_synth PF01564.17 ORX55706.1 - 4.6e-70 234.9 0.0 2.3e-69 232.6 0.0 1.9 2 0 0 2 2 2 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 ORX55706.1 - 6.9e-23 80.3 0.2 1.2e-22 79.5 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 ORX55706.1 - 0.0011 19.6 0.0 0.002 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_30 PF05430.11 ORX55706.1 - 0.032 14.1 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_12 PF08242.12 ORX55706.1 - 0.048 14.4 0.1 0.16 12.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain HATPase_c PF02518.26 ORX55707.1 - 2.7e-27 95.5 0.4 5.3e-27 94.6 0.4 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_3 PF08447.12 ORX55707.1 - 8.3e-24 83.7 0.6 2.1e-15 56.8 0.2 2.6 2 0 0 2 2 2 2 PAS fold PAS_4 PF08448.10 ORX55707.1 - 2.3e-20 72.9 0.1 6.6e-14 52.1 0.1 2.7 2 0 0 2 2 2 2 PAS fold Response_reg PF00072.24 ORX55707.1 - 1.1e-19 70.6 0.0 1.3e-18 67.2 0.0 2.5 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ORX55707.1 - 6.2e-18 64.6 0.1 1.4e-17 63.5 0.1 1.6 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 ORX55707.1 - 6.6e-14 52.0 0.0 2e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 PAS domain PAS PF00989.25 ORX55707.1 - 1.5e-12 47.5 0.0 8.3e-08 32.2 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS_8 PF13188.7 ORX55707.1 - 0.00039 20.4 0.0 0.31 11.1 0.0 2.8 2 0 0 2 2 2 2 PAS domain Ribonuclease_3 PF00636.26 ORX55708.1 - 3.7e-46 156.1 0.1 5e-23 81.7 0.0 3.0 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ORX55708.1 - 3e-26 92.1 0.0 1.5e-14 54.2 0.0 3.6 2 2 0 2 2 2 2 Ribonuclease-III-like Dicer_dimer PF03368.14 ORX55708.1 - 5.2e-21 74.6 0.0 3e-20 72.2 0.1 2.4 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 ORX55708.1 - 1.5e-17 63.9 0.1 5.6e-17 62.1 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX55708.1 - 1.5e-13 51.1 0.1 2.9e-13 50.2 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX55708.1 - 4.4e-12 46.1 0.0 9.2e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PAZ PF02170.22 ORX55708.1 - 6.5e-12 45.4 0.0 1.5e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 PAZ domain dsrm PF00035.26 ORX55708.1 - 6.1e-07 30.1 0.1 0.042 14.5 0.0 2.7 2 0 0 2 2 2 2 Double-stranded RNA binding motif SWI2_SNF2 PF18766.1 ORX55708.1 - 0.00015 21.5 0.2 0.00027 20.7 0.2 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 ORX55708.1 - 0.066 13.5 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain adh_short_C2 PF13561.6 ORX55709.1 - 1.8e-50 171.7 1.2 2.4e-50 171.3 1.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX55709.1 - 1.1e-41 142.4 1.0 1.4e-41 142.1 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX55709.1 - 7.2e-12 45.6 0.3 1e-11 45.1 0.3 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ORX55709.1 - 0.016 15.4 0.1 0.034 14.4 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain PCMT PF01135.19 ORX55709.1 - 0.023 14.4 0.2 0.033 13.9 0.2 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Polysacc_synt_2 PF02719.15 ORX55709.1 - 0.027 13.6 0.1 0.039 13.1 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ysc84 PF04366.12 ORX55709.1 - 0.027 14.2 0.4 0.072 12.8 0.1 1.8 2 0 0 2 2 2 0 Las17-binding protein actin regulator Metallophos_C PF14008.6 ORX55709.1 - 0.03 15.2 0.0 0.058 14.3 0.0 1.5 1 0 0 1 1 1 0 Iron/zinc purple acid phosphatase-like protein C F420_oxidored PF03807.17 ORX55709.1 - 0.077 13.6 0.2 0.16 12.5 0.2 1.5 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Velvet PF11754.8 ORX55710.1 - 5.2e-29 101.9 2.1 3.3e-22 79.7 0.0 2.1 1 1 1 2 2 2 2 Velvet factor Endonuclease_NS PF01223.23 ORX55711.1 - 2.7e-55 187.6 0.0 4.2e-55 187.0 0.0 1.3 2 0 0 2 2 2 1 DNA/RNA non-specific endonuclease p450 PF00067.22 ORX55712.1 - 2.8e-80 270.3 0.1 3.5e-80 270.0 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 PYRIN PF02758.16 ORX55712.1 - 0.18 12.0 0.3 0.35 11.0 0.3 1.4 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain p450 PF00067.22 ORX55713.1 - 5.3e-74 249.6 0.0 6.2e-74 249.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 M60-like_N PF17291.2 ORX55713.1 - 0.19 11.6 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of M60-like peptidases p450 PF00067.22 ORX55714.1 - 3.1e-79 266.9 0.0 4.2e-79 266.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX55715.1 - 1.1e-78 265.1 0.1 1.2e-78 264.9 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX55716.1 - 7.1e-86 288.8 0.1 8.4e-86 288.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX55717.1 - 2.7e-86 290.2 0.2 3.2e-86 289.9 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 MFS_1 PF07690.16 ORX55718.1 - 2.9e-16 59.4 20.0 2.9e-16 59.4 20.0 1.5 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 ORX55718.1 - 2.5e-07 29.6 10.5 2.5e-07 29.6 10.5 1.7 1 1 1 2 2 2 1 MFS/sugar transport protein OATP PF03137.20 ORX55718.1 - 3.4e-05 22.4 11.0 0.00061 18.2 10.6 2.3 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family PUCC PF03209.15 ORX55718.1 - 0.00067 18.8 4.4 0.00067 18.8 4.4 1.3 1 1 0 1 1 1 1 PUCC protein ELO PF01151.18 ORX55718.1 - 0.0097 15.5 4.8 0.016 14.8 4.8 1.4 1 1 0 1 1 1 1 GNS1/SUR4 family CSTF2_hinge PF14327.6 ORX55719.1 - 0.37 11.3 2.6 1.1 9.7 0.2 2.9 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 Ecl1 PF12855.7 ORX55720.1 - 0.00024 22.3 3.1 0.00032 21.9 3.1 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2256 PF10013.9 ORX55720.1 - 0.16 12.1 2.3 2.2 8.5 2.3 2.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-FLZ PF04570.14 ORX55720.1 - 2.5 7.6 5.3 30 4.2 5.3 2.1 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 Myb_DNA-binding PF00249.31 ORX55721.1 - 0.027 14.7 0.9 0.048 13.9 0.9 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain PALP PF00291.25 ORX55722.1 - 1e-44 153.1 0.0 1.5e-44 152.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ORX55722.1 - 3.5e-17 62.6 0.0 3.7e-08 33.7 0.0 3.0 2 0 0 2 2 2 2 CBS domain Perilipin PF03036.16 ORX55722.1 - 0.17 10.9 0.0 0.32 10.0 0.0 1.4 1 0 0 1 1 1 0 Perilipin family ANTH PF07651.16 ORX55723.1 - 1.1e-48 165.7 3.0 1.3e-48 165.4 3.0 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 ORX55723.1 - 0.0004 20.4 0.0 0.0013 18.8 0.0 1.9 2 0 0 2 2 2 1 ENTH domain THOC2_N PF16134.5 ORX55723.1 - 0.034 12.8 0.3 0.056 12.1 0.3 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Mucin PF01456.17 ORX55724.1 - 5.5e-05 23.2 2.0 8.1e-05 22.6 2.0 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein EVC2_like PF12297.8 ORX55724.1 - 0.26 9.9 0.4 0.36 9.5 0.4 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Prominin PF05478.11 ORX55724.1 - 0.48 8.3 8.3 0.61 8.0 8.3 1.1 1 0 0 1 1 1 0 Prominin HLH PF00010.26 ORX55725.1 - 5.8e-13 48.6 0.2 1.6e-12 47.2 0.2 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain His_Phos_2 PF00328.22 ORX55726.1 - 9.2e-23 81.2 0.0 1.3e-21 77.4 0.0 2.1 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) FHA PF00498.26 ORX55727.1 - 5.7e-08 33.0 0.1 1.7e-07 31.5 0.1 1.9 1 0 0 1 1 1 1 FHA domain Forkhead PF00250.18 ORX55727.1 - 1.5e-05 25.2 0.2 0.0001 22.4 0.0 2.1 1 1 1 2 2 2 1 Forkhead domain p450 PF00067.22 ORX55728.1 - 3.5e-83 279.9 0.1 4.3e-83 279.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX55729.1 - 5.6e-64 216.6 0.0 1.8e-31 109.4 0.0 3.0 2 1 1 3 3 3 3 Cytochrome P450 p450 PF00067.22 ORX55730.1 - 2e-80 270.8 0.0 2.7e-80 270.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF4299 PF14132.6 ORX55730.1 - 0.088 12.2 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4299) Lysyl_oxidase PF01186.17 ORX55730.1 - 0.13 11.9 0.0 0.19 11.4 0.0 1.2 1 0 0 1 1 1 0 Lysyl oxidase GMC_oxred_N PF00732.19 ORX55731.1 - 8e-50 169.9 0.2 1.4e-48 165.8 0.2 2.1 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ORX55731.1 - 3e-21 76.4 0.1 5.7e-21 75.6 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ORX55731.1 - 4.7e-09 35.8 1.8 1.2e-05 24.7 1.2 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ORX55731.1 - 1.3e-05 25.0 1.7 0.016 14.8 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX55731.1 - 0.00039 20.6 1.3 0.0011 19.2 1.3 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX55731.1 - 0.0014 18.0 0.1 0.0024 17.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX55731.1 - 0.0015 17.8 1.0 0.023 14.0 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX55731.1 - 0.0072 15.1 0.4 0.014 14.1 0.3 1.5 2 0 0 2 2 2 1 HI0933-like protein GDI PF00996.18 ORX55731.1 - 0.083 11.4 0.1 0.14 10.7 0.1 1.3 1 0 0 1 1 1 0 GDP dissociation inhibitor Pyr_redox_3 PF13738.6 ORX55731.1 - 0.089 12.0 0.2 0.45 9.7 0.5 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX55731.1 - 0.25 10.6 1.4 0.49 9.7 1.4 1.5 1 0 0 1 1 1 0 FAD dependent oxidoreductase Abhydrolase_6 PF12697.7 ORX55732.1 - 1.2e-05 26.0 0.1 1.9e-05 25.3 0.1 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family PGAP1 PF07819.13 ORX55732.1 - 2.1e-05 24.4 0.1 3.2e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 ORX55732.1 - 0.003 17.1 0.0 0.0052 16.3 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 ORX55732.1 - 0.0035 16.7 0.1 0.01 15.1 0.1 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 CD99L2 PF12301.8 ORX55732.1 - 0.011 16.0 0.0 0.02 15.2 0.0 1.3 1 0 0 1 1 1 0 CD99 antigen like protein 2 Abhydrolase_1 PF00561.20 ORX55732.1 - 0.072 12.7 0.1 0.16 11.6 0.1 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ORX55732.1 - 0.097 12.5 0.0 0.23 11.3 0.0 1.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase S-AdoMet_synt_C PF02773.16 ORX55733.1 - 2.7e-68 228.3 0.0 5.6e-68 227.2 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ORX55733.1 - 3e-47 159.8 0.0 5.6e-47 158.9 0.0 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ORX55733.1 - 1.4e-45 154.0 0.2 2.6e-45 153.1 0.2 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 ORX55733.1 - 0.057 12.2 0.4 0.14 11.0 0.2 1.6 1 1 1 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF2085 PF09858.9 ORX55734.1 - 5.6 7.5 12.5 0.49 10.9 0.6 3.2 2 2 1 3 3 3 0 Predicted membrane protein (DUF2085) LRR_4 PF12799.7 ORX55735.1 - 0.054 13.9 9.1 1.7 9.2 0.1 4.1 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX55735.1 - 0.89 10.3 6.1 20 6.2 0.2 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 ORX55735.1 - 5.7 6.8 7.0 1.5 8.6 0.4 3.1 3 2 0 3 3 3 0 Leucine rich repeat F-box-like PF12937.7 ORX55736.1 - 6e-08 32.4 0.5 6e-08 32.4 0.5 2.3 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ORX55736.1 - 4.6e-07 29.6 5.0 5.7e-07 29.3 0.5 3.0 4 0 0 4 4 4 1 F-box domain F-box_4 PF15966.5 ORX55736.1 - 0.033 14.1 1.1 0.083 12.8 0.1 2.1 2 0 0 2 2 2 0 F-box DUF1869 PF08956.10 ORX55736.1 - 0.092 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) CBS PF00571.28 ORX55737.1 - 2.1e-29 101.8 6.3 9.3e-07 29.2 0.0 6.2 5 1 0 5 5 5 4 CBS domain PB1 PF00564.24 ORX55737.1 - 1.4e-07 31.3 0.0 4e-07 29.9 0.0 1.8 1 0 0 1 1 1 1 PB1 domain HMG14_17 PF01101.18 ORX55737.1 - 0.25 12.3 2.1 0.65 11.0 2.1 1.7 1 0 0 1 1 1 0 HMG14 and HMG17 E2F_TDP PF02319.20 ORX55738.1 - 5.7e-14 51.9 0.7 5.7e-14 51.9 0.7 1.7 2 0 0 2 2 2 1 E2F/DP family winged-helix DNA-binding domain DP PF08781.10 ORX55738.1 - 7.4e-05 22.7 0.9 0.00011 22.1 0.9 1.3 1 0 0 1 1 1 1 Transcription factor DP RuvB_C PF05491.13 ORX55738.1 - 0.15 12.0 0.6 0.29 11.0 0.1 1.6 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain Vir_act_alpha_C PF10400.9 ORX55738.1 - 0.23 12.1 2.0 0.42 11.3 2.0 1.3 1 0 0 1 1 1 0 Virulence activator alpha C-term Fungal_trans PF04082.18 ORX55740.1 - 5.2e-19 68.3 1.9 1e-18 67.3 1.9 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX55740.1 - 4.4e-11 42.7 6.5 8.4e-11 41.8 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Lactamase_B_2 PF12706.7 ORX55741.1 - 2.5e-13 50.0 0.0 1.4e-05 24.7 0.0 3.1 2 1 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX55741.1 - 1.8e-07 31.4 0.0 4e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ORX55741.1 - 3e-05 23.6 0.0 5.5e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease PDEase_II PF02112.15 ORX55741.1 - 0.19 10.8 0.0 0.6 9.2 0.0 1.7 2 0 0 2 2 2 0 cAMP phosphodiesterases class-II Ag332 PF04671.12 ORX55741.1 - 0.46 10.5 2.0 0.9 9.5 2.0 1.4 1 0 0 1 1 1 0 Erythrocyte membrane-associated giant protein antigen 332 zf-C3HC4_4 PF15227.6 ORX55742.1 - 5.9e-09 35.9 7.2 8.5e-09 35.4 7.2 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ORX55742.1 - 3.5e-08 33.3 2.0 3.5e-08 33.3 2.0 1.5 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX55742.1 - 1.2e-06 28.3 7.5 1.7e-06 27.8 7.5 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX55742.1 - 1.3e-06 28.1 9.1 1.8e-06 27.7 9.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX55742.1 - 1.5e-06 28.4 9.2 2.1e-06 27.9 9.2 1.2 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX55742.1 - 2.7e-06 27.2 10.1 3.6e-06 26.7 10.1 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX55742.1 - 4.1e-06 26.7 8.8 9e-06 25.6 8.8 1.6 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX55742.1 - 8.9e-06 25.5 9.4 3.5e-05 23.6 9.4 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ORX55742.1 - 0.0012 18.6 3.6 0.0012 18.6 3.6 1.9 2 0 0 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ORX55742.1 - 0.012 15.8 4.6 0.016 15.4 4.6 1.2 1 0 0 1 1 1 0 zinc RING finger of MSL2 FoP_duplication PF13865.6 ORX55742.1 - 0.077 13.5 0.1 0.085 13.4 0.1 1.1 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 zf-rbx1 PF12678.7 ORX55742.1 - 0.14 12.4 9.8 0.48 10.8 9.8 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RRN7 PF11781.8 ORX55742.1 - 0.49 10.1 3.7 22 4.8 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 SPX PF03105.19 ORX55743.1 - 5.3e-33 115.5 3.4 6.8e-33 115.1 3.4 1.1 1 0 0 1 1 1 1 SPX domain CagE_TrbE_VirB PF03135.14 ORX55743.1 - 0.023 14.8 2.1 0.043 13.9 2.1 1.5 1 1 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system SMRP1 PF15181.6 ORX55743.1 - 0.054 13.1 0.0 0.074 12.6 0.0 1.1 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 Iron_traffic PF04362.14 ORX55743.1 - 0.12 12.1 1.2 0.26 11.0 1.2 1.5 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking MFS_1 PF07690.16 ORX55744.1 - 3.6e-42 144.6 48.0 3.6e-42 144.6 48.0 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX55744.1 - 2.8e-16 59.5 11.8 2.8e-16 59.5 11.8 2.8 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 ORX55744.1 - 1.4e-12 46.9 25.5 2e-12 46.3 25.5 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ORX55744.1 - 0.00053 18.5 5.5 0.00095 17.7 5.5 1.4 1 0 0 1 1 1 1 Transmembrane secretion effector DUF2530 PF10745.9 ORX55744.1 - 8.8 6.6 11.3 5 7.4 0.3 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2530) Thiolase_N PF00108.23 ORX55745.1 - 9.2e-92 307.1 0.2 1.3e-91 306.6 0.2 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX55745.1 - 1.1e-41 141.4 0.4 1.1e-41 141.4 0.4 2.3 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ORX55745.1 - 9.7e-05 22.1 2.1 0.00069 19.3 1.0 2.7 2 1 1 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain Ribophorin_I PF04597.14 ORX55746.1 - 7e-118 394.6 2.5 8.4e-118 394.3 2.5 1.0 1 0 0 1 1 1 1 Ribophorin I eIF2_C PF09173.11 ORX55747.1 - 3.3e-34 117.0 0.3 9.1e-34 115.6 0.3 1.8 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 ORX55747.1 - 9.7e-23 80.7 0.3 7.3e-22 77.9 0.3 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ORX55747.1 - 1.2e-08 35.2 1.8 4.5e-08 33.4 1.8 2.1 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 ORX55747.1 - 0.00043 20.2 0.2 0.0068 16.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ORX55747.1 - 0.0017 18.4 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX55747.1 - 0.055 13.5 0.0 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 Dynamin family MMR_HSR1_Xtn PF16897.5 ORX55747.1 - 0.065 13.3 0.1 0.17 11.9 0.1 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Trehalase PF01204.18 ORX55748.1 - 5.6e-179 596.2 1.6 6.8e-179 595.9 1.6 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 ORX55748.1 - 2.5e-09 36.7 0.3 4.5e-09 35.9 0.3 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Methyltransf_16 PF10294.9 ORX55749.1 - 2.9e-37 128.1 0.1 7e-36 123.6 0.1 2.1 1 1 0 1 1 1 1 Lysine methyltransferase GidB PF02527.15 ORX55749.1 - 0.0022 17.3 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G Methyltransf_23 PF13489.6 ORX55749.1 - 0.0031 17.4 0.0 0.0056 16.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX55749.1 - 0.017 14.7 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 ORX55749.1 - 0.033 13.6 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ORX55749.1 - 0.039 14.7 0.0 0.16 12.8 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain Succ_CoA_lig PF13607.6 ORX55749.1 - 0.071 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Succinyl-CoA ligase like flavodoxin domain MtrC PF04211.13 ORX55749.1 - 0.13 11.3 0.0 0.19 10.8 0.0 1.2 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit C TPR_14 PF13428.6 ORX55752.1 - 0.00022 21.8 0.3 0.07 14.0 0.1 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat AAA_lid_6 PF17866.1 ORX55752.1 - 0.0056 16.8 0.6 0.03 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA lid domain NRDE-2 PF08424.10 ORX55752.1 - 0.018 14.2 0.1 0.018 14.2 0.1 4.8 2 2 2 4 4 4 0 NRDE-2, necessary for RNA interference Lsm_interact PF05391.11 ORX55752.1 - 0.072 12.6 4.2 0.14 11.7 0.0 2.5 2 0 0 2 2 2 0 Lsm interaction motif U3_assoc_6 PF08640.11 ORX55752.1 - 0.23 11.6 10.1 0.24 11.5 0.9 3.5 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 DUF5320 PF17253.2 ORX55752.1 - 1.2 10.3 10.5 0.12 13.4 4.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF3108 PF11306.8 ORX55752.1 - 1.8 8.5 5.9 1.6 8.6 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3108) Spem1 PF15670.5 ORX55752.1 - 2.2 7.8 10.8 5.7 6.4 10.8 1.6 1 0 0 1 1 1 0 Spermatid maturation protein 1 AAA_11 PF13086.6 ORX55752.1 - 4.3 7.0 14.2 12 5.6 14.2 1.8 1 0 0 1 1 1 0 AAA domain WRKY PF03106.15 ORX55753.1 - 0.0037 17.5 2.8 0.0074 16.5 2.8 1.5 1 0 0 1 1 1 1 WRKY DNA -binding domain DUF4679 PF15728.5 ORX55754.1 - 0.21 10.6 5.6 0.22 10.5 5.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4679) DUF1748 PF08520.10 ORX55755.1 - 4.3e-25 87.4 0.1 4.8e-25 87.3 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) ABC1 PF03109.16 ORX55756.1 - 1.3e-33 115.6 0.0 2.4e-33 114.8 0.0 1.4 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ORX55756.1 - 0.0088 15.4 0.0 0.067 12.5 0.1 2.0 2 0 0 2 2 2 1 Protein kinase domain WaaY PF06176.11 ORX55756.1 - 0.13 11.9 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) RPAP3_C PF13877.6 ORX55757.1 - 7.5e-21 74.5 0.0 1.4e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 ORX55757.1 - 1.8e-10 40.2 0.2 0.00044 19.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX55757.1 - 9.8e-10 37.8 0.4 5e-05 23.1 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX55757.1 - 1.6e-07 30.9 0.2 0.011 15.9 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX55757.1 - 0.00017 21.6 0.1 0.00034 20.7 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55757.1 - 0.0036 17.5 0.6 0.0086 16.3 0.6 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX55757.1 - 0.011 15.8 0.1 0.19 11.8 0.1 2.2 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ORX55757.1 - 0.024 15.4 0.2 0.25 12.2 0.1 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX55757.1 - 0.024 15.3 0.1 0.079 13.6 0.1 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ORX55757.1 - 0.045 13.2 0.3 6.5 6.3 0.0 2.5 2 0 0 2 2 2 0 SHNi-TPR TPR_10 PF13374.6 ORX55757.1 - 0.18 11.8 0.3 27 4.8 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_hydro_18 PF00704.28 ORX55758.1 - 7.9e-65 219.6 1.0 9.2e-65 219.4 1.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 ORX55758.1 - 0.079 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 HMG_box PF00505.19 ORX55759.1 - 1.8e-40 137.2 0.4 4.6e-21 75.0 0.2 2.4 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX55759.1 - 1.5e-25 89.5 0.1 2.6e-11 43.9 0.1 2.6 2 0 0 2 2 2 2 HMG-box domain HMG_box_5 PF14887.6 ORX55759.1 - 0.0021 18.0 0.8 0.0048 16.8 0.8 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box 5 Protamine_like PF06382.11 ORX55759.1 - 0.074 13.2 0.1 0.21 11.8 0.1 1.8 1 0 0 1 1 1 0 Protamine and protamine like DUF3106 PF11304.8 ORX55759.1 - 0.85 10.1 8.5 9.8 6.7 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) BRO1 PF03097.18 ORX55760.1 - 3.7e-92 309.1 0.2 3.7e-92 309.1 0.2 2.1 2 1 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ORX55760.1 - 1.9e-64 217.8 3.8 3.2e-64 217.1 3.8 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Syntaxin_2 PF14523.6 ORX55760.1 - 0.036 14.4 0.8 0.18 12.2 0.8 2.3 1 0 0 1 1 1 0 Syntaxin-like protein JIP_LZII PF16471.5 ORX55760.1 - 0.71 10.1 6.1 27 5.0 0.0 3.7 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II Occludin_ELL PF07303.13 ORX55760.1 - 1.2 9.9 3.8 3.1 8.6 1.5 2.9 2 1 0 2 2 2 0 Occludin homology domain DEAD PF00270.29 ORX55761.1 - 1.9e-47 161.3 0.0 4.8e-47 160.0 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX55761.1 - 3.2e-31 107.9 0.0 6.2e-31 107.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX55761.1 - 0.00015 21.9 0.0 0.00025 21.1 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ORX55761.1 - 0.078 12.3 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Lipase_3 PF01764.25 ORX55762.1 - 0.0066 16.3 0.0 0.019 14.8 0.0 1.8 1 1 1 2 2 2 1 Lipase (class 3) Ribosomal_S21e PF01249.18 ORX55763.1 - 1.6e-16 60.2 0.1 1.9e-16 59.9 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S21e DUF3012 PF11216.8 ORX55764.1 - 0.087 12.9 0.7 4.4 7.4 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3012) Lipase_3 PF01764.25 ORX55765.1 - 1.8e-13 50.6 0.0 4.7e-12 46.0 0.0 2.6 1 1 0 1 1 1 1 Lipase (class 3) PPR_2 PF13041.6 ORX55766.1 - 5.7e-56 186.5 1.6 1.6e-08 34.6 0.0 17.6 14 4 7 21 21 20 12 PPR repeat family PPR PF01535.20 ORX55766.1 - 5.1e-36 120.4 13.4 0.0038 17.4 0.1 17.9 20 1 0 20 20 20 7 PPR repeat PPR_3 PF13812.6 ORX55766.1 - 4.5e-33 113.1 1.7 1.2e-09 38.1 0.0 11.5 9 4 5 14 14 14 6 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX55766.1 - 1.1e-29 103.4 7.9 1.9e-06 27.4 0.1 7.7 4 2 5 9 9 9 5 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX55766.1 - 5.1e-24 83.7 1.3 0.0018 18.0 0.0 12.9 13 0 0 13 13 13 4 PPR repeat TPR_14 PF13428.6 ORX55766.1 - 8e-05 23.2 17.6 3.6 8.7 0.0 10.2 11 0 0 11 11 10 1 Tetratricopeptide repeat RPN7 PF10602.9 ORX55766.1 - 0.022 14.5 2.9 10 5.8 0.0 4.9 3 1 3 6 6 6 0 26S proteasome subunit RPN7 RPM2 PF08579.11 ORX55766.1 - 0.032 14.7 1.3 15 6.0 0.0 4.6 5 0 0 5 5 5 0 Mitochondrial ribonuclease P subunit (RPM2) MNE1 PF13762.6 ORX55766.1 - 0.044 13.8 0.9 22 5.0 0.0 3.7 4 0 0 4 4 4 0 Mitochondrial splicing apparatus component DUF2877 PF11392.8 ORX55766.1 - 0.054 14.2 0.0 0.29 11.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) TPR_19 PF14559.6 ORX55766.1 - 0.3 11.6 22.1 5 7.7 0.8 6.8 6 1 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX55766.1 - 0.64 10.3 10.3 31 4.9 0.1 5.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX55766.1 - 0.75 10.5 12.7 8.9 7.1 0.1 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX55766.1 - 1.1 10.0 13.5 72 4.4 0.1 6.9 7 0 0 7 7 6 0 Tetratricopeptide repeat UMPH-1 PF05822.12 ORX55768.1 - 3.3e-34 118.5 0.0 3.8e-34 118.3 0.0 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) UMPH-1 PF05822.12 ORX55769.1 - 8.7e-37 127.0 0.3 9.5e-37 126.8 0.3 1.0 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) FMN_red PF03358.15 ORX55770.1 - 6.3e-07 29.3 0.0 6.4e-07 29.2 0.0 1.0 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX55770.1 - 0.00097 18.9 0.0 0.0011 18.7 0.0 1.0 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX55770.1 - 0.061 13.5 0.0 0.76 10.0 0.0 1.9 1 1 1 2 2 2 0 Flavodoxin Arrestin_C PF02752.22 ORX55772.1 - 1.3e-08 35.3 0.0 1.8e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain DnaJ PF00226.31 ORX55773.1 - 2.1e-27 95.0 3.6 4e-27 94.1 3.6 1.5 1 0 0 1 1 1 1 DnaJ domain CENP-I PF07778.11 ORX55774.1 - 8.4e-43 146.8 0.6 1.2e-42 146.4 0.6 1.2 1 0 0 1 1 1 1 Mis6 Vps5 PF09325.10 ORX55775.1 - 2.6e-68 230.1 14.8 3.6e-68 229.6 14.8 1.1 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ORX55775.1 - 3.2e-28 98.0 0.4 3.7e-25 88.1 0.0 2.3 2 0 0 2 2 2 2 PX domain BAR_3_WASP_bdg PF10456.9 ORX55775.1 - 0.0003 20.3 9.1 0.0092 15.5 9.1 2.1 1 1 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR PF03114.18 ORX55775.1 - 0.0012 18.6 15.8 0.0057 16.3 15.8 1.9 1 1 0 1 1 1 1 BAR domain DUF1002 PF06207.11 ORX55775.1 - 0.041 13.4 5.4 0.074 12.6 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) FdhE PF04216.12 ORX55775.1 - 0.051 13.4 5.3 0.091 12.6 5.3 1.3 1 0 0 1 1 1 0 Protein involved in formate dehydrogenase formation Peptidase_C11 PF03415.14 ORX55775.1 - 0.09 12.2 2.4 0.088 12.2 1.1 1.6 2 0 0 2 2 2 0 Clostripain family FAM92 PF06730.11 ORX55775.1 - 0.12 11.8 8.3 0.036 13.5 5.4 1.6 2 0 0 2 2 2 0 FAM92 protein BAR_3 PF16746.5 ORX55775.1 - 0.13 11.9 19.7 0.053 13.2 7.4 2.7 2 1 1 3 3 3 0 BAR domain of APPL family Noelin-1 PF12308.8 ORX55775.1 - 5.5 7.0 6.7 5.5 7.0 1.8 2.7 3 0 0 3 3 3 0 Neurogenesis glycoprotein FlaC_arch PF05377.11 ORX55775.1 - 8 6.9 10.8 14 6.2 0.2 4.5 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Tubulin PF00091.25 ORX55776.1 - 4.1e-70 236.0 0.0 7.3e-70 235.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX55776.1 - 1e-40 138.8 0.1 1.6e-40 138.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX55776.1 - 6.7e-06 26.4 0.0 1.4e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Hydrolase_4 PF12146.8 ORX55776.1 - 0.066 12.5 0.1 0.31 10.3 0.1 1.9 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Tubulin_2 PF13809.6 ORX55776.1 - 0.071 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Tubulin like DUF92 PF01940.16 ORX55777.1 - 0.003 17.0 0.1 0.0034 16.8 0.1 1.2 1 0 0 1 1 1 1 Integral membrane protein DUF92 GPS2_interact PF15784.5 ORX55779.1 - 0.034 14.6 0.5 0.15 12.5 0.1 2.0 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain BAR PF03114.18 ORX55779.1 - 0.038 13.6 0.2 0.051 13.2 0.2 1.1 1 0 0 1 1 1 0 BAR domain Med3 PF11593.8 ORX55779.1 - 0.074 12.2 6.0 0.081 12.1 6.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DivIC PF04977.15 ORX55779.1 - 0.078 12.8 0.2 0.1 12.4 0.2 1.1 1 0 0 1 1 1 0 Septum formation initiator Peptidase_S8 PF00082.22 ORX55779.1 - 0.1 11.8 0.6 0.11 11.7 0.6 1.1 1 0 0 1 1 1 0 Subtilase family HNOBA PF07701.14 ORX55779.1 - 0.31 10.4 1.2 0.42 10.0 1.2 1.1 1 0 0 1 1 1 0 Heme NO binding associated zf-Mss51 PF13824.6 ORX55780.1 - 0.051 13.7 0.3 3.2 7.9 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-CCHC_6 PF15288.6 ORX55780.1 - 0.42 10.5 7.8 3.1 7.7 0.5 2.6 2 0 0 2 2 2 0 Zinc knuckle Prok-RING_1 PF14446.6 ORX55780.1 - 0.81 9.7 7.0 1.4 8.9 1.5 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 ORX55780.1 - 1.2 9.3 3.9 9.2 6.5 0.3 2.5 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 ORX55780.1 - 5.1 7.2 8.0 51 4.0 8.0 2.2 1 1 0 1 1 1 0 Double zinc ribbon COesterase PF00135.28 ORX55782.1 - 6.4e-80 269.5 0.0 7.4e-80 269.2 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ORX55782.1 - 2.7e-16 60.1 1.9 3.2e-16 59.8 0.5 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX55782.1 - 3.5e-05 24.5 10.1 6e-05 23.8 10.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ORX55782.1 - 0.00015 21.3 0.1 0.00023 20.7 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ORX55782.1 - 0.00057 19.6 0.0 0.21 11.2 0.0 2.1 2 0 0 2 2 2 2 Putative esterase Chlorophyllase2 PF12740.7 ORX55782.1 - 0.0067 15.4 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 ORX55782.1 - 0.0078 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX55782.1 - 0.013 15.2 0.0 0.024 14.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX55782.1 - 0.048 12.5 0.1 0.44 9.3 0.1 2.0 1 1 0 1 1 1 0 Steryl acetyl hydrolase Peptidase_M16 PF00675.20 ORX55783.1 - 6.4e-51 172.3 2.0 1.6e-50 170.9 0.3 2.3 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 ORX55783.1 - 1e-35 123.4 0.0 7.8e-35 120.5 0.0 2.3 3 0 0 3 3 3 1 Peptidase M16 inactive domain Nucleo_P87 PF07267.11 ORX55783.1 - 0.011 14.6 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF438 PF04282.13 ORX55783.1 - 0.041 13.8 0.2 0.27 11.2 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF438) RNA_pol_Rbc25 PF08292.12 ORX55784.1 - 5.2e-38 130.2 0.0 7e-38 129.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 ORX55784.1 - 3.3e-19 69.0 0.2 5.9e-19 68.2 0.2 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ORX55784.1 - 0.032 14.6 0.0 0.079 13.3 0.0 1.8 1 1 0 1 1 1 0 S1 RNA binding domain DNA_ligase_A_M PF01068.21 ORX55784.1 - 0.21 11.2 0.0 1 9.0 0.0 1.9 2 0 0 2 2 2 0 ATP dependent DNA ligase domain Lactate_perm PF02652.14 ORX55785.1 - 1.5e-123 413.3 39.7 7.6e-73 246.0 21.9 2.0 2 0 0 2 2 2 2 L-lactate permease C2 PF00168.30 ORX55786.1 - 4.1e-92 303.3 3.9 2e-20 73.0 0.0 6.6 6 0 0 6 6 6 6 C2 domain SMP_LBD PF17047.5 ORX55786.1 - 0.047 13.2 0.0 0.16 11.4 0.0 1.9 1 1 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain DUF3455 PF11937.8 ORX55787.1 - 1.1e-08 35.6 0.0 1.2e-08 35.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) PPR_2 PF13041.6 ORX55788.1 - 1.1e-30 105.5 5.3 2e-08 34.3 0.0 8.6 8 1 1 9 9 9 4 PPR repeat family PPR_3 PF13812.6 ORX55788.1 - 3.5e-22 78.3 0.1 3.6e-06 26.9 0.0 5.5 5 1 0 5 5 5 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX55788.1 - 5.8e-17 61.1 3.2 2.6e-05 23.8 0.0 6.0 8 0 0 8 8 8 3 PPR repeat PPR PF01535.20 ORX55788.1 - 2e-16 59.0 11.6 2.4e-06 27.4 0.0 9.3 10 2 1 11 11 11 4 PPR repeat PPR_long PF17177.4 ORX55788.1 - 8e-13 48.2 0.5 0.019 14.4 0.0 5.2 4 1 1 5 5 5 3 Pentacotripeptide-repeat region of PRORP OrfB_Zn_ribbon PF07282.11 ORX55789.1 - 0.00024 21.0 0.1 0.00045 20.1 0.1 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain AMP-binding PF00501.28 ORX55790.1 - 8e-65 219.1 0.1 6.5e-33 114.0 0.0 3.0 2 1 0 2 2 2 2 AMP-binding enzyme MtrF PF09472.10 ORX55790.1 - 0.04 13.3 0.4 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) MFS_1 PF07690.16 ORX55792.1 - 3.6e-29 101.8 47.3 1.8e-18 66.6 23.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX55792.1 - 1.7e-08 33.4 15.1 1.7e-08 33.4 15.1 2.4 1 1 2 3 3 3 3 MFS/sugar transport protein Sugar_tr PF00083.24 ORX55792.1 - 0.00028 19.9 16.0 0.00028 19.9 16.0 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TMEM208_SND2 PF05620.11 ORX55792.1 - 0.43 10.4 4.9 1.6 8.5 0.4 2.7 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 LapA_dom PF06305.11 ORX55792.1 - 1 9.2 21.7 1.7 8.5 2.7 5.2 4 1 0 4 4 4 0 Lipopolysaccharide assembly protein A domain W2 PF02020.18 ORX55793.1 - 9.5e-20 70.5 1.3 2.3e-19 69.3 0.3 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon HRDC PF00570.23 ORX55793.1 - 0.00075 19.4 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Med22 PF06179.12 ORX55794.1 - 4.5e-23 81.4 3.6 5.5e-23 81.2 3.6 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Med11 PF10280.9 ORX55794.1 - 0.4 11.1 3.7 3.8 8.0 3.7 2.0 1 1 0 1 1 1 0 Mediator complex protein ABC_membrane PF00664.23 ORX55795.1 - 2e-44 152.3 2.0 2.5e-44 152.0 2.0 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX55795.1 - 1.3e-36 126.1 0.0 2.4e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX55795.1 - 6e-07 29.1 1.3 0.00018 21.0 0.0 2.4 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ORX55795.1 - 0.00012 22.4 0.4 0.0088 16.3 0.4 3.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX55795.1 - 0.00043 20.7 0.1 0.0016 18.9 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ORX55795.1 - 0.00048 20.6 0.4 0.02 15.3 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ORX55795.1 - 0.011 15.7 0.0 0.055 13.5 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_21 PF13304.6 ORX55795.1 - 0.02 14.7 0.0 2.7 7.7 0.0 2.3 1 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX55795.1 - 0.028 14.1 0.1 0.071 12.9 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ORX55795.1 - 0.03 14.3 0.0 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ORX55795.1 - 0.06 12.8 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Dala_Dala_lig_N PF01820.21 ORX55795.1 - 0.061 13.8 0.0 0.18 12.3 0.0 1.8 1 0 0 1 1 1 0 D-ala D-ala ligase N-terminus RsgA_GTPase PF03193.16 ORX55795.1 - 0.071 13.0 0.0 0.21 11.5 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase Rad17 PF03215.15 ORX55795.1 - 0.076 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain NB-ARC PF00931.22 ORX55795.1 - 0.083 12.1 0.0 0.19 10.9 0.0 1.5 2 0 0 2 2 2 0 NB-ARC domain AAA_30 PF13604.6 ORX55795.1 - 0.091 12.5 0.3 1.6 8.4 0.1 2.8 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ORX55795.1 - 0.098 12.9 0.6 1.3 9.4 0.6 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_18 PF13238.6 ORX55795.1 - 0.11 13.0 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX55795.1 - 0.14 11.7 0.0 0.49 10.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain DUF563 PF04577.14 ORX55796.1 - 1.4e-08 35.2 0.1 2.9e-08 34.1 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF563) F-box PF00646.33 ORX55797.1 - 2.1e-08 33.8 0.6 5.7e-08 32.4 0.3 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX55797.1 - 2e-05 24.4 3.3 5.3e-05 23.0 3.3 1.7 1 0 0 1 1 1 1 F-box-like PXA PF02194.15 ORX55797.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 PXA domain Dscam_C PF12355.8 ORX55799.1 - 0.73 10.8 4.2 0.66 11.0 0.3 2.1 1 1 1 2 2 2 0 Down syndrome cell adhesion molecule C terminal Rap_GAP PF02145.15 ORX55802.1 - 2.8e-42 144.4 0.0 6.6e-42 143.2 0.0 1.6 1 0 0 1 1 1 1 Rap/ran-GAP NAP PF00956.18 ORX55803.1 - 8.3e-89 297.3 9.3 8.3e-89 297.3 9.3 2.9 2 1 0 2 2 2 1 Nucleosome assembly protein (NAP) Nop14 PF04147.12 ORX55803.1 - 5.4 5.1 24.5 0.48 8.6 13.2 2.2 2 0 0 2 2 2 0 Nop14-like family VTC PF09359.10 ORX55805.1 - 5.6e-83 278.5 0.0 9.7e-83 277.7 0.0 1.4 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 ORX55805.1 - 5.8e-12 46.2 4.6 1.1e-06 28.9 0.2 3.3 1 1 2 3 3 3 3 SPX domain DUF202 PF02656.15 ORX55806.1 - 4.1e-14 52.8 3.1 4.1e-14 52.8 3.1 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF2628 PF10947.8 ORX55806.1 - 0.037 14.4 0.2 0.037 14.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2628) JAB PF01398.21 ORX55807.1 - 5.4e-33 113.5 0.3 1e-32 112.6 0.0 1.6 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ORX55807.1 - 5.3e-14 52.6 2.2 5.6e-14 52.5 1.0 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ORX55807.1 - 2e-06 27.6 0.0 3.3e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF5624 PF18538.1 ORX55807.1 - 0.014 15.5 0.1 0.024 14.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) YvfG PF09628.10 ORX55807.1 - 0.088 13.2 0.2 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 YvfG protein Inv-AAD PF18785.1 ORX55808.1 - 1.7e-28 99.0 0.3 2e-27 95.6 0.3 2.0 1 1 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 ORX55808.1 - 1.1e-20 73.3 1.0 1.4e-20 73.1 1.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX55808.1 - 1.8e-08 34.2 0.1 2.3e-08 33.9 0.1 1.1 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.11 ORX55808.1 - 7e-05 22.8 0.2 0.0003 20.7 0.2 1.9 1 1 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC3 PF18771.1 ORX55808.1 - 0.00099 19.2 0.0 0.0021 18.1 0.0 1.5 1 1 0 1 1 1 1 APOBEC3 SNAD4 PF18750.1 ORX55808.1 - 0.05 13.7 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 ORX55808.1 - 0.091 12.8 0.1 0.13 12.4 0.1 1.2 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 Sel1 PF08238.12 ORX55809.1 - 8.8e-21 73.9 3.3 4.9e-08 33.4 0.4 4.1 4 0 0 4 4 4 3 Sel1 repeat Atrophin-1 PF03154.15 ORX55809.1 - 0.012 14.0 6.8 0.014 13.7 6.8 1.0 1 0 0 1 1 1 0 Atrophin-1 family TPR_6 PF13174.6 ORX55809.1 - 0.11 13.2 0.1 17 6.3 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat MINDY_DUB PF04424.13 ORX55809.1 - 0.12 12.4 0.0 5.4 7.1 0.0 2.3 1 1 1 2 2 2 0 MINDY deubiquitinase TPR_11 PF13414.6 ORX55809.1 - 0.16 11.7 0.1 1.7 8.4 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 ORX55809.1 - 0.18 12.0 5.6 0.67 10.2 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX55809.1 - 0.39 10.6 8.3 0.93 9.4 0.0 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX55809.1 - 0.54 10.6 6.6 11 6.5 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.8 ORX55810.1 - 1e-36 126.7 0.9 1e-36 126.7 0.9 10.7 5 3 2 7 7 7 1 Spt20 family FCH PF00611.23 ORX55811.1 - 1.8e-06 28.1 6.9 1.4e-05 25.3 0.1 3.0 3 0 0 3 3 3 2 Fes/CIP4, and EFC/F-BAR homology domain SH3_1 PF00018.28 ORX55811.1 - 0.043 13.4 0.0 0.094 12.3 0.0 1.6 1 0 0 1 1 1 0 SH3 domain TMEM247 PF15444.6 ORX55811.1 - 0.11 12.5 4.6 0.25 11.4 4.6 1.5 1 0 0 1 1 1 0 Transmembrane protein 247 Draxin PF15550.6 ORX55811.1 - 0.2 11.5 11.3 0.41 10.5 11.3 1.5 1 0 0 1 1 1 0 Draxin AIP3 PF03915.13 ORX55812.1 - 3.6e-43 148.2 15.4 4.5e-43 147.9 15.4 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 DUF1664 PF07889.12 ORX55812.1 - 0.02 14.9 6.8 0.033 14.2 0.2 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Spore_III_AB PF09548.10 ORX55812.1 - 0.041 14.0 2.0 0.061 13.4 0.9 2.0 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Rx_N PF18052.1 ORX55812.1 - 0.27 11.5 0.0 0.27 11.5 0.0 4.4 3 2 1 4 4 4 0 Rx N-terminal domain PTS_IIA PF02255.16 ORX55812.1 - 0.55 10.3 6.0 0.083 13.0 1.0 2.2 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIA subunit FAA_hydro_N_2 PF18288.1 ORX55812.1 - 2.2 8.8 5.6 7.9 7.0 0.2 3.2 3 1 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 AIP3 PF03915.13 ORX55813.1 - 2.8e-06 26.7 1.0 8.7e-06 25.1 0.0 2.1 2 1 1 3 3 3 1 Actin interacting protein 3 Glyco_hydro_61 PF03443.14 ORX55814.1 - 0.019 14.9 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 61 Adenyl_transf PF04439.12 ORX55814.1 - 0.051 12.7 0.0 0.07 12.2 0.0 1.1 1 0 0 1 1 1 0 Streptomycin adenylyltransferase DUF5447 PF17525.2 ORX55815.1 - 0.11 13.0 1.1 0.31 11.5 1.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5447) FlxA PF14282.6 ORX55815.1 - 0.11 12.4 3.1 0.24 11.4 3.1 1.5 1 0 0 1 1 1 0 FlxA-like protein IFT57 PF10498.9 ORX55815.1 - 0.14 11.1 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Evr1_Alr PF04777.13 ORX55816.1 - 1.3e-29 102.6 3.8 1.3e-29 102.6 3.8 1.9 2 1 0 2 2 2 1 Erv1 / Alr family Got1 PF04178.12 ORX55817.1 - 9.9e-27 93.6 14.0 1.2e-26 93.3 14.0 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family 2-Hacid_dh_C PF02826.19 ORX55818.1 - 2.3e-57 193.2 0.0 3.1e-57 192.8 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX55818.1 - 2.5e-30 104.8 0.0 3e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ORX55818.1 - 5.8e-06 26.6 0.0 9.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 ORX55818.1 - 0.0055 16.3 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ORX55818.1 - 0.0057 17.2 0.0 0.011 16.4 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 ORX55818.1 - 0.0064 16.6 0.1 0.011 15.8 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.20 ORX55818.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 ORX55818.1 - 0.048 14.1 0.0 0.2 12.1 0.0 2.0 2 0 0 2 2 2 0 Putative NAD(P)-binding Utp14 PF04615.13 ORX55819.1 - 8.8e-204 679.3 74.1 8.8e-204 679.3 74.1 2.0 1 1 1 2 2 2 1 Utp14 protein Glyco_hydro_18 PF00704.28 ORX55820.1 - 1.7e-14 54.3 0.1 3.8e-14 53.1 0.1 1.6 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 GST_C_6 PF17171.4 ORX55820.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Zip PF02535.22 ORX55821.1 - 1.4e-28 100.1 2.7 4e-28 98.6 2.7 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter BPD_transp_2 PF02653.16 ORX55821.1 - 0.0084 15.3 2.4 0.0084 15.3 2.4 2.4 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component Pkinase PF00069.25 ORX55822.1 - 4.4e-72 242.6 0.0 7.7e-72 241.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX55822.1 - 6.5e-42 143.6 0.0 1.1e-41 142.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX55822.1 - 7.6e-07 29.3 0.0 0.0027 17.7 0.0 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX55822.1 - 4.7e-06 26.1 1.8 0.00018 20.9 0.2 2.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX55822.1 - 1.3e-05 24.6 0.0 2.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 ORX55822.1 - 0.00019 21.1 0.0 0.0005 19.7 0.0 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ORX55822.1 - 0.011 14.7 0.1 0.011 14.7 0.1 1.9 2 0 0 2 2 2 0 Haspin like kinase domain RIO1 PF01163.22 ORX55822.1 - 0.021 14.4 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 ORX55822.1 - 0.18 10.7 0.0 0.3 10.0 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Alginate_lyase PF05426.12 ORX55823.1 - 2e-10 40.7 0.0 2.5e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Alginate lyase TB2_DP1_HVA22 PF03134.19 ORX55825.1 - 1.1e-31 108.6 4.4 1.1e-31 108.6 4.4 1.7 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Erythrovirus_X PF06795.11 ORX55825.1 - 0.0058 16.9 0.2 0.013 15.8 0.2 1.6 1 0 0 1 1 1 1 Erythrovirus X protein Peptidase_M76 PF09768.9 ORX55826.1 - 1.4e-69 233.3 6.5 1.7e-69 233.0 6.5 1.1 1 0 0 1 1 1 1 Peptidase M76 family Peptidase_M90 PF06167.12 ORX55826.1 - 0.062 12.9 0.4 0.2 11.3 0.1 1.9 2 0 0 2 2 2 0 Glucose-regulated metallo-peptidase M90 Peptidase_M78 PF06114.13 ORX55826.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain DnaJ PF00226.31 ORX55827.1 - 8.3e-23 80.3 4.8 1e-22 80.0 4.8 1.1 1 0 0 1 1 1 1 DnaJ domain DUF1653 PF07866.11 ORX55827.1 - 0.045 14.1 2.0 0.061 13.6 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1653) zf-C2HC5 PF06221.13 ORX55828.1 - 2.9e-20 72.0 6.6 5e-20 71.2 6.6 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type PWI PF01480.17 ORX55828.1 - 0.0064 16.8 0.1 0.02 15.2 0.1 1.9 1 0 0 1 1 1 1 PWI domain Kelch_6 PF13964.6 ORX55829.1 - 2e-05 24.7 0.1 3.5e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 ORX55829.1 - 2.6e-05 24.1 0.3 4.2e-05 23.4 0.3 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 ORX55829.1 - 9.9e-05 21.8 0.1 0.00014 21.4 0.1 1.2 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ORX55829.1 - 0.0017 18.3 0.2 0.0034 17.3 0.2 1.5 1 1 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX55829.1 - 0.0022 18.2 0.1 0.0032 17.7 0.1 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX55829.1 - 0.036 14.1 0.3 0.075 13.0 0.3 1.7 1 1 0 1 1 1 0 Kelch motif BTB PF00651.31 ORX55830.1 - 1.4e-14 54.2 0.0 3.2e-14 53.1 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain Kelch_3 PF13415.6 ORX55830.1 - 0.018 15.4 3.6 0.47 10.8 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain SLAIN PF15301.6 ORX55830.1 - 0.16 11.2 15.7 0.25 10.5 15.7 1.2 1 0 0 1 1 1 0 SLAIN motif-containing family OrsD PF12013.8 ORX56145.1 - 0.019 15.4 0.1 0.055 13.9 0.1 1.8 1 0 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D MMR_HSR1 PF01926.23 ORX56147.1 - 6.2e-14 52.1 0.0 1.5e-12 47.6 0.0 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX56147.1 - 2.3e-05 24.4 0.1 0.00034 20.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 ORX56147.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX56147.1 - 0.0037 17.3 1.0 0.025 14.7 0.2 2.6 2 1 1 3 3 3 1 Dynamin family Roc PF08477.13 ORX56147.1 - 0.015 15.5 0.2 0.05 13.8 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 ORX56147.1 - 0.016 14.5 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Septin PF00735.18 ORX56147.1 - 0.051 12.9 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Septin PduV-EutP PF10662.9 ORX56147.1 - 0.14 11.9 0.0 0.69 9.7 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RAB3GAP2_N PF14655.6 ORX56148.1 - 4.9e-90 302.8 0.1 4e-54 184.5 0.3 2.1 1 1 1 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus AA_permease_2 PF13520.6 ORX56149.1 - 2e-65 221.3 49.7 2.4e-65 221.0 49.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX56149.1 - 5.1e-28 97.9 45.1 6.4e-28 97.6 45.1 1.0 1 0 0 1 1 1 1 Amino acid permease TPR_14 PF13428.6 ORX56150.1 - 5.4e-17 61.0 15.8 0.077 13.9 0.1 11.7 8 4 4 12 12 12 2 Tetratricopeptide repeat Suf PF05843.14 ORX56150.1 - 1.1e-12 48.5 8.9 0.012 15.7 0.0 6.2 2 2 2 5 5 5 3 Suppressor of forked protein (Suf) TPR_2 PF07719.17 ORX56150.1 - 5.7e-09 35.4 17.5 0.15 12.2 0.0 9.6 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX56150.1 - 1.6e-08 34.1 11.2 0.00076 19.5 0.0 7.9 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX56150.1 - 9.4e-07 28.3 7.3 0.45 9.7 0.4 5.1 4 1 0 5 5 5 3 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ORX56150.1 - 5.1e-06 26.5 13.7 0.91 9.5 0.1 6.9 7 1 0 7 7 7 3 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 ORX56150.1 - 1.2e-05 25.5 9.5 0.013 15.8 0.0 6.6 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX56150.1 - 1.6e-05 25.3 7.1 2.9 8.5 0.2 7.1 8 2 1 9 9 9 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX56150.1 - 6.2e-05 22.7 7.5 0.83 9.6 0.0 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX56150.1 - 0.00012 21.3 8.2 0.0057 15.8 0.2 6.1 2 2 3 6 6 6 1 NRDE-2, necessary for RNA interference TPR_1 PF00515.28 ORX56150.1 - 0.00015 21.5 10.5 0.9 9.5 0.1 6.7 8 0 0 8 8 6 2 Tetratricopeptide repeat Mad3_BUB1_I_2 PF17014.5 ORX56150.1 - 0.00026 21.1 0.0 0.66 10.1 0.0 2.8 2 0 0 2 2 2 2 Putative Mad3/BUB1 like region 1 protein TPR_17 PF13431.6 ORX56150.1 - 0.00028 21.1 10.8 3 8.4 0.1 7.7 9 1 0 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX56150.1 - 0.00075 20.0 8.1 19 6.2 0.1 7.1 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX56150.1 - 0.0079 16.2 11.0 10 6.4 0.0 7.1 8 1 0 8 8 7 0 Tetratricopeptide repeat RPN7 PF10602.9 ORX56150.1 - 0.01 15.5 0.2 3.9 7.1 0.1 3.7 3 1 0 3 3 3 0 26S proteasome subunit RPN7 MIT PF04212.18 ORX56150.1 - 0.012 15.7 1.0 0.6 10.2 0.0 4.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ORX56150.1 - 0.032 13.6 1.0 1.4 8.2 0.1 4.0 4 2 1 5 5 5 0 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ORX56150.1 - 0.036 14.7 8.4 16 6.2 0.5 5.5 5 1 0 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 ORX56150.1 - 0.2 12.0 3.7 42 4.7 0.0 5.2 6 0 0 6 6 4 0 PPR repeat TPR_4 PF07721.14 ORX56150.1 - 1.1 10.0 5.6 33 5.5 0.0 4.4 5 0 0 5 5 3 0 Tetratricopeptide repeat Heme_oxygenase PF01126.20 ORX56152.1 - 3.5e-53 180.5 0.3 4.6e-53 180.1 0.3 1.2 1 0 0 1 1 1 1 Heme oxygenase PPR_2 PF13041.6 ORX56153.1 - 6.7e-31 106.2 9.9 2.7e-08 33.9 0.0 8.5 7 4 0 7 7 7 4 PPR repeat family PPR_3 PF13812.6 ORX56153.1 - 9.3e-17 60.9 5.9 2e-06 27.8 0.0 5.0 4 1 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.20 ORX56153.1 - 1.8e-16 59.2 13.7 0.084 13.2 0.0 10.5 11 1 0 11 11 11 5 PPR repeat PPR_1 PF12854.7 ORX56153.1 - 3e-10 39.6 8.6 0.033 13.9 0.0 8.5 8 2 1 9 9 9 2 PPR repeat PPR_long PF17177.4 ORX56153.1 - 5.1e-08 32.5 0.1 9.3e-05 21.9 0.0 3.7 2 2 2 4 4 4 2 Pentacotripeptide-repeat region of PRORP Ssu72 PF04722.13 ORX56153.1 - 0.0021 17.6 0.2 0.0064 16.1 0.0 1.8 2 0 0 2 2 2 1 Ssu72-like protein TPR_19 PF14559.6 ORX56153.1 - 0.0035 17.8 4.9 0.011 16.2 0.1 3.5 6 0 0 6 6 6 1 Tetratricopeptide repeat ATP13 PF12921.7 ORX56153.1 - 0.034 14.0 0.1 23 4.9 0.0 3.9 4 0 0 4 4 4 0 Mitochondrial ATPase expression Acetyltransf_1 PF00583.25 ORX56154.1 - 2.1e-16 60.2 0.0 2.6e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX56154.1 - 4.4e-09 36.7 0.0 5.9e-09 36.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX56154.1 - 4.5e-07 29.9 0.0 7e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX56154.1 - 3.1e-05 23.8 0.0 6.1e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ORX56154.1 - 0.0015 19.2 0.0 0.002 18.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX56154.1 - 0.041 14.0 0.0 0.078 13.1 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_6 PF13480.7 ORX56154.1 - 0.16 12.1 0.1 2.1 8.5 0.0 2.1 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ORX56154.1 - 0.25 10.8 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 Putative acetyl-transferase Sacchrp_dh_C PF16653.5 ORX56155.1 - 3e-85 286.5 0.0 5.4e-85 285.7 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain AlaDh_PNT_N PF05222.15 ORX56155.1 - 1.5e-27 96.6 0.0 3.4e-27 95.4 0.0 1.7 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_NADP PF03435.18 ORX56155.1 - 1.1e-22 80.7 0.4 2.2e-22 79.7 0.4 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ORX56155.1 - 3.1e-06 27.3 0.1 6.5e-06 26.3 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 ORX56155.1 - 1.6e-05 24.3 0.0 0.0039 16.5 0.0 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_10 PF13460.6 ORX56155.1 - 0.00012 22.0 2.1 0.00035 20.5 1.2 2.3 2 1 0 2 2 2 1 NAD(P)H-binding NAD_binding_7 PF13241.6 ORX56155.1 - 0.0002 21.7 0.1 0.00041 20.7 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding DapB_N PF01113.20 ORX56155.1 - 0.002 18.2 0.7 0.004 17.3 0.7 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 ORX56155.1 - 0.039 14.4 0.1 0.095 13.1 0.1 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain WD40_4 PF16300.5 ORX56155.1 - 0.062 13.2 0.0 0.16 11.9 0.0 1.7 1 0 0 1 1 1 0 Type of WD40 repeat CMAS PF02353.20 ORX56155.1 - 0.083 12.2 0.0 1.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase Rax2 PF12768.7 ORX56156.1 - 9.4e-30 103.7 4.6 1.5e-28 99.7 0.5 3.5 2 1 2 4 4 4 1 Cortical protein marker for cell polarity SH3_1 PF00018.28 ORX56156.1 - 1.8e-10 40.3 1.2 4e-10 39.1 0.3 2.2 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ORX56156.1 - 4.3e-10 39.3 0.1 9.6e-10 38.2 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX56156.1 - 2.8e-08 33.3 0.0 5.4e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Kelch_6 PF13964.6 ORX56156.1 - 0.0028 17.9 6.2 2.1 8.8 0.1 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ORX56156.1 - 0.15 11.7 3.3 34 4.1 0.2 4.9 5 0 0 5 5 5 0 Kelch motif Spc7_C2 PF15577.6 ORX56156.1 - 0.17 12.0 0.1 1 9.5 0.0 2.3 2 0 0 2 2 2 0 Spc7_C2 DUF5122 PF17164.4 ORX56156.1 - 0.21 11.9 26.5 0.33 11.3 0.3 8.1 9 0 0 9 9 9 0 Domain of unknown function (DUF5122) beta-propeller DEAD_2 PF06733.15 ORX56159.1 - 3.5e-44 150.5 0.2 6.3e-44 149.7 0.2 1.4 1 0 0 1 1 1 1 DEAD_2 Helicase_C_2 PF13307.6 ORX56159.1 - 2.9e-24 86.2 0.0 7.3e-24 84.8 0.0 1.8 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 ORX56159.1 - 6.1e-08 32.8 0.1 0.00075 19.5 0.0 2.9 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX56159.1 - 6.6e-05 22.7 0.0 0.0036 17.1 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_11 PF13086.6 ORX56159.1 - 0.00024 21.0 0.1 0.79 9.4 0.0 3.4 3 1 0 4 4 4 1 AAA domain AAA_22 PF13401.6 ORX56159.1 - 0.0034 17.7 0.1 4.3 7.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain MutL_C PF08676.11 ORX56159.1 - 0.062 13.1 0.5 0.26 11.1 0.0 2.3 2 0 0 2 2 2 0 MutL C terminal dimerisation domain Phage_connect_1 PF05135.13 ORX56160.1 - 0.011 16.2 0.2 0.011 16.2 0.2 3.6 3 0 0 3 3 3 0 Phage gp6-like head-tail connector protein RNR_Alpha PF17975.1 ORX56160.1 - 4.6 7.8 7.0 6.6 7.3 0.5 3.7 3 0 0 3 3 3 0 Ribonucleotide reductase alpha domain DUF726 PF05277.12 ORX56161.1 - 4.9e-119 397.3 0.8 8.5e-119 396.5 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF726) GATA PF00320.27 ORX56162.1 - 1.9e-14 52.9 4.7 1.9e-14 52.9 4.7 2.0 2 0 0 2 2 2 1 GATA zinc finger zf-C3HC4_3 PF13920.6 ORX56162.1 - 0.73 9.7 3.7 0.23 11.3 0.3 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF448 PF04296.13 ORX56163.1 - 0.0025 17.6 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF448) Glyco_transf_22 PF03901.17 ORX56164.1 - 1.1e-75 255.5 26.2 4.8e-75 253.3 26.2 1.8 1 1 0 1 1 1 1 Alg9-like mannosyltransferase family 3HCDH_N PF02737.18 ORX56165.1 - 5.5e-59 199.1 5.7 7.4e-59 198.6 5.7 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ORX56165.1 - 7.1e-33 113.1 0.1 2.1e-32 111.6 0.0 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX56165.1 - 0.031 13.9 0.3 0.047 13.3 0.3 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 ORX56165.1 - 0.043 14.0 1.9 0.066 13.4 0.7 1.9 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Sacchrp_dh_NADP PF03435.18 ORX56165.1 - 0.045 14.0 1.1 0.088 13.1 1.1 1.5 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Pyr_redox_2 PF07992.14 ORX56165.1 - 0.048 12.9 0.2 0.069 12.4 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.22 ORX56166.1 - 3.7e-20 71.5 0.0 8.1e-09 35.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PUF PF00806.19 ORX56166.1 - 1.2e-19 68.8 0.1 6.3e-06 25.6 0.1 5.3 5 0 0 5 5 5 4 Pumilio-family RNA binding repeat Nab6_mRNP_bdg PF10567.9 ORX56166.1 - 5.4e-06 26.1 0.0 0.0038 16.8 0.0 2.4 2 0 0 2 2 2 2 RNA-recognition motif DUF4523 PF15023.6 ORX56166.1 - 8.1e-06 25.7 0.0 0.044 13.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF4523) RRM_occluded PF16842.5 ORX56166.1 - 7.2e-05 22.6 0.0 0.073 12.9 0.0 2.5 2 0 0 2 2 2 2 Occluded RNA-recognition motif MgtE_N PF03448.17 ORX56166.1 - 0.017 15.7 0.3 3.6 8.3 0.1 2.8 3 0 0 3 3 3 0 MgtE intracellular N domain Pinin_SDK_memA PF04696.13 ORX56167.1 - 7.1e-17 61.7 18.3 6.9e-12 45.6 8.9 3.0 2 1 1 3 3 3 2 pinin/SDK/memA/ protein conserved region zf-HC2 PF13490.6 ORX56167.1 - 0.21 11.9 0.6 0.41 10.9 0.6 1.5 1 0 0 1 1 1 0 Putative zinc-finger Ion_trans PF00520.31 ORX56168.1 - 2.4e-138 459.2 84.5 1.4e-41 142.3 11.6 4.3 4 0 0 4 4 4 4 Ion transport protein GPHH PF16905.5 ORX56168.1 - 0.00047 19.9 0.2 0.0016 18.1 0.0 2.1 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated BSMAP PF12280.8 ORX56168.1 - 0.031 14.5 0.2 0.22 11.7 0.0 2.5 3 0 0 3 3 3 0 Brain specific membrane anchored protein zf-rbx1 PF12678.7 ORX56169.1 - 7.2e-11 42.2 7.0 2.6e-10 40.4 7.0 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ORX56169.1 - 5.6e-08 33.0 3.4 5.6e-08 33.0 3.4 3.1 4 0 0 4 4 4 1 Ring finger domain zf-C3HC4 PF00097.25 ORX56169.1 - 2.7e-06 27.1 3.3 1.5e-05 24.8 3.3 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX56169.1 - 3e-06 27.1 7.5 2.5e-05 24.2 7.5 2.4 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX56169.1 - 5.7e-05 22.9 3.3 5.7e-05 22.9 3.3 2.7 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX56169.1 - 0.00067 19.2 0.9 0.00067 19.2 0.9 2.4 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 ORX56169.1 - 0.0057 16.4 4.3 0.0057 16.4 4.3 2.9 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 ORX56169.1 - 0.017 15.3 0.4 0.017 15.3 0.4 1.9 2 0 0 2 2 1 0 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 ORX56169.1 - 0.019 14.8 4.8 0.38 10.6 1.2 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX56169.1 - 0.022 14.8 8.4 0.079 13.0 5.9 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 ORX56169.1 - 0.064 13.4 2.1 0.2 11.9 2.1 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Prok-RING_4 PF14447.6 ORX56169.1 - 0.09 12.7 4.8 0.29 11.0 1.4 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ORX56169.1 - 0.4 10.7 10.7 0.23 11.5 6.1 2.7 2 1 1 3 3 3 0 zinc-RING finger domain Glyco_transf_41 PF13844.6 ORX56171.1 - 2.3e-114 382.5 0.5 8.4e-55 186.0 0.0 3.2 2 1 0 3 3 3 3 Glycosyl transferase family 41 TPR_1 PF00515.28 ORX56171.1 - 2.1e-21 74.8 3.4 2.1e-05 24.1 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX56171.1 - 1.2e-18 65.7 0.8 5e-07 29.4 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX56171.1 - 4.7e-18 63.8 1.0 0.0011 18.9 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX56171.1 - 4.9e-15 54.9 5.1 8.8e-05 22.1 0.0 6.5 3 2 3 6 6 6 3 TPR repeat TPR_17 PF13431.6 ORX56171.1 - 9.4e-15 53.9 3.5 0.0019 18.4 0.0 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_10 PF13374.6 ORX56171.1 - 1.4e-12 47.0 11.9 0.0017 18.2 0.0 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX56171.1 - 2.9e-12 46.7 1.5 0.014 15.7 0.1 5.8 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ORX56171.1 - 5e-10 39.9 0.1 0.0018 18.9 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX56171.1 - 9e-08 31.6 0.9 0.031 14.3 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX56171.1 - 1.1e-07 32.1 0.0 0.62 11.0 0.0 5.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX56171.1 - 5.5e-07 30.0 0.0 0.002 18.6 0.0 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX56171.1 - 0.0015 18.6 0.3 0.28 11.3 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat NARP1 PF12569.8 ORX56171.1 - 0.13 11.2 0.0 2.2 7.1 0.0 2.5 3 0 0 3 3 3 0 NMDA receptor-regulated protein 1 SRR1 PF07985.12 ORX56172.1 - 7.9e-17 61.0 0.0 1.7e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 SRR1 EMC1_C PF07774.13 ORX56173.1 - 5.6e-68 228.8 0.0 1.2e-67 227.7 0.0 1.6 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 ORX56173.1 - 1.8e-09 37.5 8.0 6.2e-07 29.2 2.6 3.9 3 0 0 3 3 3 3 PQQ-like domain Mannosidase_ig PF17786.1 ORX56173.1 - 0.15 12.7 3.3 1.3 9.7 0.1 3.5 4 0 0 4 4 4 0 Mannosidase Ig/CBM-like domain Peptidase_S10 PF00450.22 ORX56174.1 - 2e-72 244.9 1.1 2.2e-72 244.7 1.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase OrfB_Zn_ribbon PF07282.11 ORX56175.1 - 2e-10 40.4 4.4 4.4e-10 39.3 1.1 2.7 2 0 0 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX56175.1 - 1.2 9.3 8.0 1.4 9.0 4.4 2.3 2 0 0 2 2 2 0 Double zinc ribbon Methyltransf_10 PF05971.12 ORX56176.1 - 1.7e-67 227.9 0.0 2.1e-67 227.6 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 ORX56176.1 - 4.6e-07 29.6 0.0 7.5e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 ORX56176.1 - 0.022 14.5 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 PrmA PF06325.13 ORX56176.1 - 0.073 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) N6_Mtase PF02384.16 ORX56176.1 - 0.17 11.1 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase Med31 PF05669.12 ORX56177.1 - 1.3e-35 121.2 10.0 1.6e-35 121.0 10.0 1.1 1 0 0 1 1 1 1 SOH1 HAD_2 PF13419.6 ORX56177.1 - 0.05 13.7 0.0 0.057 13.5 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ins_allergen_rp PF06757.13 ORX56177.1 - 0.11 12.4 1.4 7.9 6.4 0.2 2.2 1 1 1 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification NmrA PF05368.13 ORX56178.1 - 2.4e-15 56.7 0.1 3e-15 56.4 0.1 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX56178.1 - 6.8e-12 45.7 0.0 1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 ORX56178.1 - 0.0016 18.3 0.0 0.012 15.5 0.0 2.1 2 0 0 2 2 2 1 KR domain Putative_PNPOx PF01243.20 ORX56178.1 - 0.057 13.6 0.1 0.3 11.3 0.0 2.1 2 1 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Polysacc_synt_2 PF02719.15 ORX56178.1 - 0.082 12.0 0.0 0.16 11.1 0.0 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein TPR_19 PF14559.6 ORX56179.1 - 6.6e-08 33.0 7.0 9.6e-05 22.8 2.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX56179.1 - 3.2e-05 23.7 4.7 1.5 9.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX56179.1 - 0.00024 21.7 4.8 13 6.9 0.0 4.9 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX56179.1 - 0.00041 20.1 2.4 1.4 8.9 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX56179.1 - 0.0012 18.9 1.1 7.1 6.9 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX56179.1 - 0.0015 18.8 3.1 0.04 14.2 0.4 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX56179.1 - 0.003 17.5 0.6 7.2 6.9 0.1 3.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX56179.1 - 0.003 18.2 3.1 0.024 15.3 0.1 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 ORX56179.1 - 0.0031 17.3 3.5 0.3 10.7 2.7 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain TPR_8 PF13181.6 ORX56179.1 - 0.0047 17.0 1.2 4.6 7.7 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX56179.1 - 0.0089 16.2 3.3 0.085 13.1 0.6 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ORX56179.1 - 0.022 15.4 4.3 0.54 11.0 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat RPN7 PF10602.9 ORX56179.1 - 0.03 14.1 0.2 0.099 12.3 0.1 2.0 2 1 0 2 2 2 0 26S proteasome subunit RPN7 HemY_N PF07219.13 ORX56179.1 - 0.19 12.0 3.7 0.33 11.2 0.4 2.4 1 1 1 2 2 2 0 HemY protein N-terminus Rit1_C PF17184.4 ORX56180.1 - 3.3e-95 318.6 0.1 5.6e-95 317.9 0.1 1.3 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ORX56180.1 - 3.8e-25 88.3 0.0 9.3e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 Rit1 DUSP-like domain Tubulin PF00091.25 ORX56181.1 - 3.9e-70 236.1 0.0 6.4e-70 235.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX56181.1 - 2.2e-40 137.7 0.0 3.4e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX56181.1 - 6e-06 26.6 0.7 9.7e-06 25.9 0.0 1.7 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ORX56181.1 - 0.029 13.6 0.0 0.065 12.4 0.0 1.5 1 0 0 1 1 1 0 Tubulin like RRM_1 PF00076.22 ORX56182.1 - 6.2e-35 118.9 0.1 4.1e-16 58.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX56182.1 - 2.2e-10 40.5 0.1 7.7e-05 22.7 0.0 2.7 2 2 0 2 2 2 2 RNA recognition motif Collagen PF01391.18 ORX56182.1 - 7e-05 22.5 9.2 0.00013 21.7 9.2 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) PHM7_cyt PF14703.6 ORX56182.1 - 0.0045 17.3 0.3 0.079 13.2 0.0 2.6 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 ORX56182.1 - 0.0099 15.9 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ORX56182.1 - 0.066 13.3 0.0 1.1 9.3 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif DUF488 PF04343.13 ORX56183.1 - 0.71 10.5 5.3 0.25 12.0 2.2 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF488 DUF1644 PF07800.12 ORX56184.1 - 0.0025 17.9 1.6 0.0025 17.9 1.6 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1644) DUF4298 PF14131.6 ORX56184.1 - 0.24 11.4 0.5 0.66 10.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) NifQ PF04891.12 ORX56184.1 - 2.5 8.4 8.5 2.4 8.5 1.8 2.5 2 0 0 2 2 2 0 NifQ DUF3512 PF12024.8 ORX56185.1 - 6e-07 29.2 0.4 1.5e-06 27.9 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3512) Dehydrin PF00257.19 ORX56186.1 - 0.052 14.1 1.0 0.09 13.3 0.3 1.6 1 1 0 1 1 1 0 Dehydrin AMP-binding PF00501.28 ORX56188.1 - 8.9e-87 291.4 0.0 1e-86 291.2 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX56188.1 - 4.4e-22 78.8 0.1 8.8e-22 77.9 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF2015 PF09435.10 ORX56189.1 - 3.7e-28 97.6 0.0 4.2e-28 97.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) Sas10_Utp3 PF04000.15 ORX56190.1 - 5.3e-13 49.4 0.1 7.8e-13 48.9 0.1 1.2 1 0 0 1 1 1 1 Sas10/Utp3/C1D family Molybdopterin_N PF18364.1 ORX56190.1 - 0.0094 15.9 0.3 0.023 14.7 0.1 1.8 2 0 0 2 2 2 1 Molybdopterin oxidoreductase N-terminal domain FUSC_2 PF13515.6 ORX56191.1 - 3.5e-14 53.0 16.8 3.5e-14 53.0 16.8 3.0 2 1 1 3 3 3 1 Fusaric acid resistance protein-like ALMT PF11744.8 ORX56191.1 - 1.7e-13 50.3 7.2 1.7e-13 50.3 7.2 3.1 3 0 0 3 3 3 2 Aluminium activated malate transporter ArAE_2 PF10334.9 ORX56191.1 - 1.4e-09 38.2 5.5 2.2e-09 37.5 1.7 2.6 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 FUSC PF04632.12 ORX56191.1 - 2.6e-05 23.0 13.1 2.6e-05 23.0 13.1 3.2 4 0 0 4 4 4 2 Fusaric acid resistance protein family PGA2 PF07543.12 ORX56191.1 - 2.2 8.3 10.2 0.054 13.5 3.3 1.8 2 0 0 2 2 2 0 Protein trafficking PGA2 Integrase_H2C2 PF17921.1 ORX56192.1 - 5.9e-09 35.9 1.0 1.8e-08 34.4 0.2 2.0 2 0 0 2 2 2 1 Integrase zinc binding domain zf-H2C2 PF09337.10 ORX56192.1 - 0.068 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 H2C2 zinc finger Rap_GAP PF02145.15 ORX56193.1 - 3.6e-48 163.6 0.0 6.7e-48 162.7 0.0 1.5 1 0 0 1 1 1 1 Rap/ran-GAP Pkinase PF00069.25 ORX56194.1 - 1.8e-67 227.5 0.0 2.5e-67 227.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56194.1 - 9.6e-40 136.5 0.0 1.5e-39 135.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 ORX56194.1 - 8.2e-20 70.9 0.3 3e-19 69.1 0.1 2.1 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ORX56194.1 - 0.0034 17.7 0.0 0.17 12.2 0.0 2.6 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 ORX56194.1 - 0.0041 16.0 0.0 0.0072 15.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX56194.1 - 0.0051 15.8 0.2 0.009 15.0 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain CENP-B_dimeris PF09026.10 ORX56194.1 - 0.067 13.6 0.2 0.17 12.3 0.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Kinase-like PF14531.6 ORX56194.1 - 0.08 12.2 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ORX56194.1 - 0.097 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family UPF0121 PF03661.13 ORX56195.1 - 1.4e-33 116.3 13.4 1.9e-33 115.9 13.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF1201 PF06716.11 ORX56196.1 - 8.5 6.5 8.8 0.47 10.5 2.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) ABC_tran PF00005.27 ORX56198.1 - 3e-17 63.4 0.1 2.8e-11 44.1 0.0 2.3 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ORX56198.1 - 6e-07 29.6 0.1 0.03 14.1 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX56198.1 - 9.2e-05 22.4 0.0 0.00016 21.6 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ORX56198.1 - 0.00024 20.6 0.0 0.43 10.0 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX56198.1 - 0.0011 19.0 0.0 0.0022 18.1 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX56198.1 - 0.0021 17.8 0.1 0.0038 16.9 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF87 PF01935.17 ORX56198.1 - 0.0073 16.4 0.7 0.012 15.7 0.7 1.3 1 0 0 1 1 1 1 Helicase HerA, central domain Zeta_toxin PF06414.12 ORX56198.1 - 0.035 13.4 0.1 0.055 12.7 0.1 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 ORX56198.1 - 0.054 14.0 0.0 0.088 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ORX56198.1 - 0.068 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Dynamin family DUF815 PF05673.13 ORX56198.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_16 PF13191.6 ORX56198.1 - 0.13 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX56198.1 - 0.15 12.3 0.1 0.7 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Cellulase PF00150.18 ORX56199.1 - 2.4e-21 76.4 2.0 5.7e-21 75.2 2.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 ORX56199.1 - 7.4e-18 64.9 0.1 1.4e-17 63.9 0.1 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Big_5 PF13205.6 ORX56199.1 - 0.1 13.3 2.1 0.36 11.5 2.1 2.0 1 0 0 1 1 1 0 Bacterial Ig-like domain GST_C PF00043.25 ORX56199.1 - 0.16 12.2 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GMC_oxred_N PF00732.19 ORX56201.1 - 5.9e-55 186.7 0.1 2.4e-54 184.8 0.3 1.8 2 0 0 2 2 2 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ORX56201.1 - 4.4e-23 82.4 0.2 1.1e-22 81.1 0.2 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ORX56201.1 - 3.6e-13 49.4 3.7 2.6e-07 30.1 1.7 2.6 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 ORX56201.1 - 1.2e-07 31.7 3.4 0.00069 19.3 0.0 3.1 3 0 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX56201.1 - 1.1e-05 25.5 1.2 2.8e-05 24.3 1.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ORX56201.1 - 2.9e-05 23.0 8.0 0.00087 18.1 1.2 3.2 3 0 0 3 3 3 2 HI0933-like protein Pyr_redox_2 PF07992.14 ORX56201.1 - 7e-05 22.2 0.3 0.004 16.4 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX56201.1 - 0.0024 17.2 0.2 0.0061 15.9 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 ORX56201.1 - 0.012 14.9 1.3 0.2 10.9 1.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 ORX56201.1 - 0.013 15.1 0.0 0.038 13.6 0.0 1.8 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA FAD_oxidored PF12831.7 ORX56201.1 - 0.018 14.4 4.9 0.027 13.8 4.0 1.8 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ORX56201.1 - 0.032 14.8 0.8 0.55 10.8 0.2 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX56201.1 - 0.043 12.9 0.3 0.092 11.8 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A M16C_assoc PF08367.11 ORX56201.1 - 0.08 12.1 1.3 0.18 10.9 0.6 1.8 2 0 0 2 2 2 0 Peptidase M16C associated GMC_oxred_N PF00732.19 ORX56202.1 - 2e-48 165.3 1.2 3.1e-48 164.7 1.2 1.3 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ORX56202.1 - 2.1e-29 102.9 0.9 3.8e-29 102.1 0.2 1.8 2 0 0 2 2 2 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ORX56202.1 - 6.5e-13 48.5 3.5 1.3e-06 27.8 1.7 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 ORX56202.1 - 2.3e-07 30.8 4.3 2.1e-06 27.6 4.3 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX56202.1 - 3.1e-07 29.9 0.2 3.7e-05 23.1 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX56202.1 - 5.5e-05 23.3 2.8 9.6e-05 22.5 1.0 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX56202.1 - 6e-05 22.4 2.5 0.2 10.9 1.4 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ORX56202.1 - 6.7e-05 21.8 3.4 0.00072 18.4 0.9 2.2 2 0 0 2 2 2 1 HI0933-like protein Lycopene_cycl PF05834.12 ORX56202.1 - 0.00055 19.1 0.6 0.0034 16.5 0.1 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_oxidored PF12831.7 ORX56202.1 - 0.0029 17.0 4.0 0.034 13.5 3.5 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase ApbA PF02558.16 ORX56202.1 - 0.0035 17.0 0.1 0.0072 16.0 0.1 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 ORX56202.1 - 0.013 14.7 1.8 0.12 11.5 0.3 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ORX56202.1 - 0.015 14.5 0.9 0.015 14.5 0.9 1.6 2 0 0 2 2 2 0 FAD binding domain Pyr_redox PF00070.27 ORX56202.1 - 0.024 15.2 0.3 0.065 13.8 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 ORX56202.1 - 0.1 11.1 0.0 0.2 10.1 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor TrkA_N PF02254.18 ORX56202.1 - 0.12 12.6 0.2 0.5 10.6 0.0 2.1 3 0 0 3 3 3 0 TrkA-N domain 2-oxoacid_dh PF00198.23 ORX56203.1 - 5.6e-82 274.7 0.2 7.9e-82 274.2 0.2 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX56203.1 - 1.5e-16 60.0 1.9 2.6e-16 59.2 1.9 1.4 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.19 ORX56203.1 - 0.00042 20.2 0.3 0.00083 19.2 0.3 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein HlyD_3 PF13437.6 ORX56203.1 - 0.039 14.7 0.5 8.9 7.1 0.0 2.5 1 1 1 2 2 2 0 HlyD family secretion protein CCDC53 PF10152.9 ORX56203.1 - 0.085 13.3 2.9 0.13 12.7 2.9 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex RnfC_N PF13375.6 ORX56203.1 - 0.22 11.5 2.6 0.3 11.1 0.2 2.2 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain HLH PF00010.26 ORX56204.1 - 1.1e-12 47.6 0.4 1.1e-12 47.6 0.4 2.7 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain Vasculin PF15337.6 ORX56204.1 - 0.036 14.9 0.3 0.036 14.9 0.3 2.7 4 0 0 4 4 4 0 Vascular protein family Vasculin-like 1 HpaB_N PF11794.8 ORX56204.1 - 0.12 12.0 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Enkurin PF13864.6 ORX56204.1 - 0.65 10.5 0.0 0.65 10.5 0.0 3.7 3 1 0 3 3 3 0 Calmodulin-binding FAM199X PF15814.5 ORX56204.1 - 0.86 8.6 7.7 1.5 7.8 7.5 1.6 1 1 0 1 1 1 0 Protein family FAM199X Forkhead PF00250.18 ORX56205.1 - 5.4e-05 23.4 0.2 9.4e-05 22.6 0.2 1.3 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 ORX56205.1 - 0.0036 17.6 1.1 0.0036 17.6 1.1 2.3 2 2 0 2 2 2 1 FHA domain Complex1_30kDa PF00329.19 ORX56206.1 - 1.9e-47 160.8 0.0 3.1e-47 160.2 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit DUF2089 PF09862.9 ORX56206.1 - 0.02 14.9 0.0 0.037 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) ANTH PF07651.16 ORX56207.1 - 6.4e-46 156.6 3.7 8.1e-46 156.2 3.7 1.1 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 ORX56207.1 - 3e-05 24.1 0.1 6.7e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 ENTH domain Vac_Fusion PF02346.16 ORX56207.1 - 0.14 11.8 0.5 3.4 7.4 0.1 2.6 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 CN_hydrolase PF00795.22 ORX56208.1 - 4.4e-64 216.3 0.0 5.1e-64 216.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF364 PF04016.12 ORX56208.1 - 0.044 13.4 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Putative heavy-metal chelation Kelch_4 PF13418.6 ORX56208.1 - 0.098 12.7 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF4148 PF13663.6 ORX56209.1 - 0.11 12.7 0.8 0.37 11.0 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4148) Fungal_trans PF04082.18 ORX56213.1 - 2.6e-19 69.3 2.9 8.4e-19 67.6 2.9 1.8 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX56213.1 - 4.1e-10 39.6 6.3 6.9e-10 38.9 6.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CASP_C PF08172.12 ORX56214.1 - 1e-57 195.4 2.2 1e-57 195.4 2.2 4.3 3 1 1 4 4 4 1 CASP C terminal Golgin_A5 PF09787.9 ORX56214.1 - 0.0016 18.0 3.8 0.0016 18.0 3.8 5.1 4 2 0 4 4 4 1 Golgin subfamily A member 5 CENP-H PF05837.12 ORX56214.1 - 0.071 13.5 0.1 0.071 13.5 0.1 6.2 5 1 1 6 6 6 0 Centromere protein H (CENP-H) DUF406 PF04175.12 ORX56214.1 - 0.26 11.8 0.0 0.26 11.8 0.0 4.2 3 2 1 4 4 4 0 Protein of unknown function (DUF406) DUF4706 PF15797.5 ORX56214.1 - 1 9.9 10.8 0.33 11.5 6.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4706) UpxZ PF06603.11 ORX56214.1 - 1.8 8.9 10.5 8.9 6.6 6.0 3.6 3 0 0 3 3 3 0 UpxZ family of transcription anti-terminator antagonists LURAP PF14854.6 ORX56214.1 - 6.8 6.7 12.1 0.19 11.7 0.2 3.5 4 0 0 4 4 4 0 Leucine rich adaptor protein Fungal_trans PF04082.18 ORX56215.1 - 1.3e-28 99.8 0.3 2.5e-28 98.9 0.3 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain CRR7 PF12095.8 ORX56215.1 - 0.095 13.2 0.1 0.37 11.3 0.1 2.0 1 0 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 FAM184 PF15665.5 ORX56216.1 - 0.00066 19.5 86.2 0.0028 17.5 34.5 12.0 1 1 8 10 10 10 4 Family with sequence similarity 184, A and B LigT_PEase PF02834.16 ORX56216.1 - 4.6 7.5 8.6 12 6.2 0.1 5.2 3 0 0 3 3 3 0 LigT like Phosphoesterase DAGK_cat PF00781.24 ORX56217.1 - 9.5e-24 83.4 0.1 2.1e-23 82.3 0.1 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain MFS_1 PF07690.16 ORX56219.1 - 3.8e-34 118.2 39.5 7.9e-34 117.1 39.5 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ORX56219.1 - 5.5e-14 51.5 26.5 8.6e-14 50.9 26.2 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 ORX56219.1 - 5.3e-12 45.3 12.1 5.3e-12 45.3 12.1 3.4 1 1 2 3 3 3 1 Sugar (and other) transporter DUF2070 PF09843.9 ORX56220.1 - 0.23 9.7 14.2 0.33 9.2 14.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4293 PF14126.6 ORX56220.1 - 1.8 8.8 7.2 0.39 11.0 3.2 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4293) Mob1_phocein PF03637.17 ORX56221.1 - 9e-64 214.5 3.0 1e-63 214.4 3.0 1.0 1 0 0 1 1 1 1 Mob1/phocein family Aa_trans PF01490.18 ORX56222.1 - 1.8e-11 43.4 33.6 1.8e-11 43.4 33.6 1.6 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ORX56222.1 - 0.00044 19.4 19.1 0.00044 19.4 19.1 1.9 1 1 0 1 1 1 1 Tryptophan/tyrosine permease family 6PF2K PF01591.18 ORX56223.1 - 3.6e-77 258.6 0.2 5e-77 258.2 0.2 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ORX56223.1 - 1.7e-35 122.5 0.0 2.8e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ORX56223.1 - 3.2e-05 24.1 0.1 7e-05 23.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain His_Phos_2 PF00328.22 ORX56223.1 - 0.057 12.8 0.1 0.18 11.1 0.0 1.7 1 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) CBS PF00571.28 ORX56224.1 - 5.1e-33 113.3 6.5 2.1e-08 34.5 0.0 5.3 5 0 0 5 5 5 4 CBS domain PB1 PF00564.24 ORX56224.1 - 4.6e-07 29.7 2.5 7e-06 25.9 2.5 2.5 1 1 0 1 1 1 1 PB1 domain Sedlin_N PF04628.13 ORX56225.1 - 2.8e-26 92.2 0.4 3.3e-26 92.0 0.4 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 ORX56225.1 - 0.023 14.6 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Sybindin-like family MPC PF03650.13 ORX56226.1 - 3.5e-35 120.5 0.1 4e-35 120.3 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers PEX11 PF05648.14 ORX56227.1 - 2.5e-55 187.4 0.2 2.8e-55 187.2 0.2 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Ras PF00071.22 ORX56228.1 - 2.7e-60 202.7 0.0 3.2e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX56228.1 - 2.4e-33 114.9 0.0 4.9e-33 113.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX56228.1 - 1.3e-12 47.6 0.0 1.6e-12 47.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX56228.1 - 0.00011 22.3 0.0 0.00023 21.2 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX56228.1 - 0.0043 16.6 0.2 0.056 13.0 0.2 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX56228.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX56228.1 - 0.039 13.9 0.1 0.59 10.0 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase DAP3 PF10236.9 ORX56228.1 - 0.053 12.7 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.6 ORX56228.1 - 0.11 12.2 0.1 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ORX56228.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain PI3_PI4_kinase PF00454.27 ORX56229.1 - 2.8e-49 168.2 0.0 8.6e-49 166.6 0.0 1.9 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SMG1 PF15785.5 ORX56229.1 - 5e-27 94.6 1.9 3.2e-26 91.9 0.0 3.1 2 1 0 2 2 2 1 Serine/threonine-protein kinase smg-1 FATC PF02260.20 ORX56229.1 - 5.1e-09 35.8 3.1 2.2e-07 30.6 0.2 3.7 3 0 0 3 3 3 1 FATC domain IL7 PF01415.16 ORX56229.1 - 0.028 14.5 3.2 0.51 10.4 0.7 2.9 2 0 0 2 2 2 0 Interleukin 7/9 family zf-RING_2 PF13639.6 ORX56230.1 - 0.047 14.0 14.3 0.081 13.3 14.3 1.4 1 0 0 1 1 1 0 Ring finger domain BLM10_N PF16547.5 ORX56232.1 - 0.029 14.6 0.0 0.057 13.7 0.0 1.5 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, N-terminal BLM10_mid PF16507.5 ORX56233.1 - 5.5e-163 543.4 0.0 9.8e-163 542.6 0.0 1.4 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 ORX56233.1 - 6.6e-34 115.7 0.0 7.6e-32 109.1 0.0 3.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) HEAT_2 PF13646.6 ORX56233.1 - 0.00022 21.6 0.1 0.0076 16.6 0.0 3.5 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 ORX56233.1 - 0.0021 18.1 2.2 29 5.3 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat Proteasome PF00227.26 ORX56234.1 - 4.4e-61 205.7 0.3 6.8e-61 205.1 0.3 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX56234.1 - 5.7e-13 48.3 0.1 1e-12 47.5 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature FtsZ_C PF12327.8 ORX56234.1 - 0.029 14.7 0.8 0.063 13.6 0.8 1.5 1 0 0 1 1 1 0 FtsZ family, C-terminal domain FoP_duplication PF13865.6 ORX56235.1 - 4.2e-14 52.8 2.4 4.2e-14 52.8 2.4 2.9 1 1 2 3 3 3 1 C-terminal duplication domain of Friend of PRMT1 HECT PF00632.25 ORX56236.1 - 1.8e-74 251.0 0.0 3.2e-74 250.2 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) AZUL PF16558.5 ORX56236.1 - 6.1e-11 42.4 3.3 1.7e-10 41.0 3.3 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A AAA_assoc PF14363.6 ORX56236.1 - 0.035 14.4 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 Domain associated at C-terminal with AAA ATP-synt_C PF00137.21 ORX56239.1 - 6e-27 93.8 29.8 6.5e-15 55.2 11.7 2.8 3 0 0 3 3 3 2 ATP synthase subunit C G0-G1_switch_2 PF15103.6 ORX56239.1 - 0.64 10.5 1.6 1.3 9.5 0.5 2.0 2 0 0 2 2 2 0 G0/G1 switch protein 2 Oxidored_q2 PF00420.24 ORX56239.1 - 0.78 9.4 9.8 0.037 13.7 1.3 2.8 3 1 1 4 4 4 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF2165 PF09933.9 ORX56239.1 - 1.1 9.2 8.8 1.4 8.9 1.3 2.7 1 1 2 3 3 3 0 Predicted small integral membrane protein (DUF2165) DUF745 PF05335.13 ORX56240.1 - 0.073 12.8 9.0 2.4 7.9 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) RepB PF07506.11 ORX56240.1 - 0.074 13.1 0.3 0.074 13.1 0.3 1.9 2 0 0 2 2 2 0 RepB plasmid partitioning protein NPV_P10 PF05531.12 ORX56240.1 - 3.5 8.2 7.4 4.4 7.8 5.1 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 ORX56240.1 - 9.3 6.4 8.3 8.9 6.5 0.5 3.2 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family MDD_C PF18376.1 ORX56241.1 - 1.4e-70 236.9 0.0 1.9e-70 236.4 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ORX56241.1 - 1e-08 35.3 1.5 2.5e-08 34.1 1.5 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain UreF PF01730.16 ORX56241.1 - 0.013 16.1 0.0 0.048 14.2 0.0 2.0 1 1 1 2 2 2 0 UreF Pex16 PF08610.10 ORX56242.1 - 1e-60 205.6 1.8 3e-60 204.1 1.8 1.6 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) tRNA-synt_1c PF00749.21 ORX56243.1 - 1.9e-104 349.0 0.0 2.3e-104 348.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain RabGAP-TBC PF00566.18 ORX56244.1 - 3.3e-29 102.1 3.1 3.3e-29 102.1 3.1 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Gpi16 PF04113.14 ORX56245.1 - 1.7e-173 578.1 0.1 3.2e-172 573.9 0.1 1.9 1 1 0 1 1 1 1 Gpi16 subunit, GPI transamidase component HSP70 PF00012.20 ORX56246.1 - 8.2e-08 30.9 0.0 3.4e-07 28.8 0.0 2.0 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX56246.1 - 0.12 11.2 0.0 0.28 9.9 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein DSPc PF00782.20 ORX56247.1 - 2.9e-35 121.0 0.2 2.2e-24 85.8 0.1 2.6 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX56247.1 - 0.0006 19.4 0.0 0.0017 18.0 0.0 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DUF1877 PF08974.10 ORX56247.1 - 0.042 14.0 0.0 3.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1877) Sep15_SelM PF08806.11 ORX56247.1 - 0.086 13.0 0.0 0.38 10.9 0.0 2.1 1 0 0 1 1 1 0 Sep15/SelM redox domain Succ_CoA_lig PF13607.6 ORX56247.1 - 0.12 12.2 0.0 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain UQ_con PF00179.26 ORX56248.1 - 8e-38 129.2 0.0 1.4e-37 128.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX56248.1 - 0.0043 16.8 0.0 0.011 15.5 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic E2 family B ALG3 PF05208.13 ORX56249.1 - 5.7e-138 460.2 24.1 7e-138 459.9 24.1 1.0 1 0 0 1 1 1 1 ALG3 protein Pcc1 PF09341.10 ORX56250.1 - 1.4e-23 82.8 0.5 1.6e-23 82.6 0.5 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 VQ PF05678.14 ORX56250.1 - 0.032 13.7 0.2 0.061 12.8 0.2 1.5 1 0 0 1 1 1 0 VQ motif UbiA PF01040.18 ORX56251.1 - 5.5e-56 189.7 15.9 6.6e-56 189.4 15.9 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family CI-B14_5a PF07347.12 ORX56252.1 - 0.00011 22.0 0.5 0.0002 21.2 0.4 1.6 1 1 0 1 1 1 1 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) Ras PF00071.22 ORX56254.1 - 9.6e-54 181.3 0.4 1.1e-53 181.1 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX56254.1 - 3.3e-20 72.5 0.1 5.2e-20 71.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX56254.1 - 4.2e-08 32.8 0.1 4.9e-08 32.6 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX56254.1 - 9.6e-06 25.3 0.8 2.1e-05 24.2 0.3 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX56254.1 - 0.00026 21.1 0.1 0.00037 20.5 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX56254.1 - 0.0026 17.7 2.0 1.2 9.0 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase G-alpha PF00503.20 ORX56254.1 - 0.0032 16.7 0.2 0.88 8.7 0.0 2.1 1 1 0 2 2 2 2 G-protein alpha subunit LRR_4 PF12799.7 ORX56255.1 - 0.00092 19.6 6.4 7.6 7.1 0.0 5.1 2 2 1 4 4 4 2 Leucine Rich repeats (2 copies) DUF1244 PF06844.11 ORX56255.1 - 0.092 12.9 0.0 0.77 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) LRR_6 PF13516.6 ORX56255.1 - 3.4 8.0 7.2 12 6.3 0.1 4.9 7 0 0 7 7 7 0 Leucine Rich repeat Pkinase PF00069.25 ORX56257.1 - 2.7e-54 184.3 0.6 4.1e-54 183.7 0.6 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56257.1 - 5.2e-22 78.4 0.1 1.8e-20 73.3 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX56257.1 - 0.00023 21.2 0.0 0.00046 20.2 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX56257.1 - 0.0071 15.7 0.0 0.052 12.8 0.0 2.1 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 ORX56257.1 - 0.013 15.1 0.0 0.032 13.8 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 ORX56257.1 - 0.029 13.7 0.1 0.051 12.9 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ORX56257.1 - 0.042 13.4 0.4 0.061 12.9 0.4 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Macscav_rec PF03523.13 ORX56257.1 - 0.13 12.1 0.8 0.26 11.2 0.8 1.5 1 0 0 1 1 1 0 Macrophage scavenger receptor CAP_N PF01213.19 ORX56259.1 - 0.014 14.9 0.0 0.016 14.7 0.0 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HrpB7 PF09486.10 ORX56259.1 - 0.12 12.8 0.4 0.16 12.4 0.4 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) RNase_PH PF01138.21 ORX56261.1 - 3.8e-19 69.5 0.0 5.5e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX56261.1 - 1.7e-10 40.7 0.0 3e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Campylo_MOMP PF05538.11 ORX56261.1 - 0.057 12.4 0.0 0.071 12.1 0.0 1.1 1 0 0 1 1 1 0 Campylobacter major outer membrane protein PGAP1 PF07819.13 ORX56263.1 - 1.4e-68 231.0 0.0 1.8e-68 230.7 0.0 1.1 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 ORX56263.1 - 5.5e-06 27.1 0.8 7.8e-06 26.6 0.8 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF676 PF05057.14 ORX56263.1 - 0.008 15.7 0.0 0.017 14.6 0.0 1.7 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Lipase_3 PF01764.25 ORX56263.1 - 0.02 14.8 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Palm_thioest PF02089.15 ORX56263.1 - 0.034 14.0 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF915 PF06028.11 ORX56263.1 - 0.077 12.3 0.0 1.1 8.6 0.0 2.3 2 1 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) Hydrolase_4 PF12146.8 ORX56263.1 - 0.11 11.8 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF92 PF01940.16 ORX56264.1 - 8.4 5.7 8.4 0.38 10.1 0.2 2.3 2 1 0 2 2 2 0 Integral membrane protein DUF92 Acyl-CoA_dh_1 PF00441.24 ORX56265.1 - 6.1e-31 107.7 0.9 1.1e-30 106.8 0.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 ORX56265.1 - 4.9e-19 68.2 0.0 1.1e-18 67.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 ORX56265.1 - 8.8e-17 61.1 0.1 1.5e-16 60.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX56265.1 - 3.6e-09 37.3 0.0 1e-08 35.8 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX56265.1 - 1.2e-05 25.6 0.0 2.7e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB PF03241.13 ORX56265.1 - 0.048 12.7 0.2 1.4 8.0 0.1 2.3 2 0 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase C terminal HpaB_N PF11794.8 ORX56265.1 - 0.13 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal QueF_N PF14819.6 ORX56265.1 - 0.14 12.5 0.0 0.34 11.3 0.0 1.6 1 0 0 1 1 1 0 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term Pkinase PF00069.25 ORX56266.1 - 1.5e-62 211.4 0.0 2e-62 210.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56266.1 - 8.6e-33 113.7 0.0 1.2e-32 113.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX56266.1 - 0.0015 17.9 0.1 0.0029 17.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX56266.1 - 0.04 13.8 0.2 0.5 10.2 0.3 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX56266.1 - 0.059 12.7 0.0 1.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 ORX56266.1 - 0.19 11.3 0.4 6.2 6.4 0.1 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RPA_C PF08784.11 ORX56267.1 - 9e-13 48.8 0.1 1.5e-12 48.1 0.1 1.4 1 0 0 1 1 1 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 ORX56267.1 - 1e-07 31.8 0.0 1.8e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RMI2 PF16100.5 ORX56267.1 - 0.038 13.8 0.0 0.068 13.0 0.0 1.5 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 DUF2987 PF11205.8 ORX56267.1 - 0.067 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2987) AMP-binding PF00501.28 ORX56268.1 - 1.2e-91 307.5 0.0 1.4e-91 307.3 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX56268.1 - 1e-23 84.1 0.1 3.6e-23 82.3 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RGS PF00615.19 ORX56269.1 - 9.7e-28 96.8 1.4 4e-27 94.8 0.2 2.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 ORX56269.1 - 7.8e-07 29.1 0.0 0.0062 16.6 0.0 3.2 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) IL11 PF07400.11 ORX56269.1 - 0.0072 16.0 0.9 0.028 14.1 0.2 2.2 2 0 0 2 2 2 1 Interleukin 11 RRM_Rrp7 PF17799.1 ORX56269.1 - 0.038 13.8 0.1 5 6.9 0.0 2.6 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Vma12 PF11712.8 ORX56270.1 - 0.081 13.0 0.4 0.13 12.4 0.4 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Acyl-CoA_dh_1 PF00441.24 ORX56271.1 - 4.8e-31 108.0 1.8 1.1e-30 106.9 1.8 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 ORX56271.1 - 1.1e-18 67.2 0.0 2.8e-18 65.8 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 ORX56271.1 - 5e-18 65.1 0.1 9.1e-18 64.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX56271.1 - 6.1e-09 36.5 0.0 1.6e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX56271.1 - 2.5e-06 27.8 0.2 5.8e-06 26.6 0.2 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Aminotran_1_2 PF00155.21 ORX56272.1 - 1.3e-63 215.4 0.0 1.5e-63 215.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ORX56272.1 - 0.00019 20.8 0.0 0.00027 20.3 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_3 PF00202.21 ORX56272.1 - 0.0007 18.4 0.0 0.00084 18.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Cys_Met_Meta_PP PF01053.20 ORX56272.1 - 0.0073 14.9 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX56272.1 - 0.027 13.8 0.0 0.045 13.1 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_C12 PF01088.21 ORX56273.1 - 1.2e-38 132.9 0.0 2.2e-38 132.1 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 FMN_dh PF01070.18 ORX56274.1 - 1.2e-120 402.8 0.5 1.5e-120 402.4 0.5 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ORX56274.1 - 5.1e-24 84.2 0.0 1.2e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ORX56274.1 - 1.5e-08 34.2 0.0 2.8e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ORX56274.1 - 0.00016 20.8 0.8 0.00027 20.0 0.2 1.6 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ORX56274.1 - 0.0041 16.6 0.1 0.0058 16.1 0.1 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase M20_dimer PF07687.14 ORX56274.1 - 0.045 13.7 0.0 0.13 12.2 0.0 1.8 1 0 0 1 1 1 0 Peptidase dimerisation domain His_biosynth PF00977.21 ORX56274.1 - 0.12 11.8 0.2 0.39 10.1 0.1 1.8 1 1 0 1 1 1 0 Histidine biosynthesis protein PHD PF00628.29 ORX56275.1 - 7e-07 29.0 4.3 1.4e-06 28.1 4.3 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ORX56275.1 - 0.12 12.7 2.4 0.23 11.7 2.4 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain LCD1 PF09798.9 ORX56275.1 - 4.3 5.7 7.0 6.9 5.1 7.0 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein zf-PHD-like PF15446.6 ORX56275.1 - 4.5 6.9 10.6 0.065 12.9 1.3 2.5 2 1 1 3 3 3 0 PHD/FYVE-zinc-finger like domain tRNA-synt_2 PF00152.20 ORX56276.1 - 6.8e-81 271.8 0.1 1e-80 271.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX56276.1 - 0.0014 18.5 0.1 0.0034 17.3 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain EVE PF01878.18 ORX56276.1 - 0.32 11.0 1.1 0.62 10.1 1.1 1.4 1 0 0 1 1 1 0 EVE domain RRM_1 PF00076.22 ORX56277.1 - 4.1e-21 74.6 0.0 5.8e-21 74.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX56277.1 - 8.4e-07 28.6 0.0 1.7e-06 27.6 0.0 1.5 1 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4525 PF15027.6 ORX56277.1 - 0.1 12.3 0.1 0.15 11.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) RRM_3 PF08777.11 ORX56277.1 - 0.15 12.1 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif LRR_8 PF13855.6 ORX56279.1 - 3.8e-18 65.0 28.7 6.9e-07 28.9 6.0 4.4 1 1 2 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ORX56279.1 - 1.4e-13 50.7 32.6 0.013 16.0 1.1 6.2 4 1 3 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX56279.1 - 3.2e-05 23.9 22.8 2.1 9.2 0.6 8.8 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_9 PF14580.6 ORX56279.1 - 0.051 13.1 4.2 3.1 7.3 0.2 2.9 1 1 2 3 3 3 0 Leucine-rich repeat GPI-anchored PF10342.9 ORX56280.1 - 3.3e-15 56.6 1.3 7.3e-15 55.5 1.3 1.6 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF5386 PF17360.2 ORX56282.1 - 0.063 13.2 0.1 0.073 13.0 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5386) OrfB_Zn_ribbon PF07282.11 ORX56283.1 - 3.2e-06 27.0 4.1 1.1e-05 25.2 4.1 1.9 1 1 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_Zn_ribbon PF07282.11 ORX56284.1 - 3.4e-06 26.9 4.3 1.2e-05 25.1 4.3 1.9 1 1 0 1 1 1 1 Putative transposase DNA-binding domain SNF2_N PF00176.23 ORX56285.1 - 8.4e-66 222.1 7.4 3.8e-65 219.9 0.1 3.1 3 1 0 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX56285.1 - 1.4e-23 83.3 0.4 1.4e-21 77.0 0.0 3.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX56285.1 - 4.3e-12 46.4 1.7 9.7e-12 45.2 0.0 2.5 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX56285.1 - 3.3e-07 30.2 0.0 1.1e-06 28.5 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Tht1 PF04163.12 ORX56287.1 - 3.5e-09 36.0 0.1 3.8e-09 35.9 0.1 1.0 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein RET_CLD4 PF17813.1 ORX56287.1 - 0.024 14.9 0.0 0.034 14.4 0.0 1.2 1 0 0 1 1 1 0 RET Cadherin like domain 4 Herpes_LMP2 PF07415.11 ORX56288.1 - 0.0061 15.4 2.2 0.0075 15.1 2.2 1.1 1 0 0 1 1 1 1 Gammaherpesvirus latent membrane protein (LMP2) protein AGTRAP PF06396.11 ORX56288.1 - 0.14 11.9 2.7 0.22 11.3 2.7 1.4 1 0 0 1 1 1 0 Angiotensin II, type I receptor-associated protein (AGTRAP) DUF1356 PF07092.12 ORX56289.1 - 0.018 14.3 0.1 0.028 13.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1356) PQ-loop PF04193.14 ORX56290.1 - 1.6e-25 88.7 13.0 2.6e-13 49.5 1.3 3.3 3 0 0 3 3 3 2 PQ loop repeat RIO1 PF01163.22 ORX56291.1 - 9.9e-49 165.5 0.1 1.9e-48 164.6 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 ORX56291.1 - 1.8e-34 117.8 0.1 4.2e-34 116.6 0.1 1.7 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 ORX56291.1 - 7.6e-11 42.4 0.4 0.00021 21.3 0.2 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX56291.1 - 3.5e-08 33.0 0.1 0.0026 17.1 0.0 2.5 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family RILP PF11461.8 ORX56291.1 - 0.097 12.9 1.8 0.35 11.1 1.8 1.9 1 0 0 1 1 1 0 Rab interacting lysosomal protein SNF2_N PF00176.23 ORX56292.1 - 1.9e-79 267.0 0.0 3.3e-79 266.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX56292.1 - 7.8e-14 52.0 0.0 1.7e-13 50.9 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HIRAN PF08797.11 ORX56292.1 - 2.9e-13 49.6 0.0 5.8e-13 48.6 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain zf-C3HC4_3 PF13920.6 ORX56292.1 - 4.7e-09 36.0 9.7 9.2e-09 35.0 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX56292.1 - 1.6e-07 31.2 8.7 3e-07 30.3 8.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ORX56292.1 - 2.2e-07 31.1 9.4 4.5e-07 30.1 9.4 1.6 1 0 0 1 1 1 1 Ring finger domain DEAD PF00270.29 ORX56292.1 - 2.7e-07 30.5 0.0 2e-06 27.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX56292.1 - 1e-06 28.8 0.0 2.6e-06 27.5 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 ORX56292.1 - 5.2e-06 26.2 9.8 1e-05 25.3 9.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX56292.1 - 1.5e-05 24.9 5.3 1.5e-05 24.9 5.3 2.5 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX56292.1 - 1.6e-05 24.7 10.6 3.4e-05 23.6 10.6 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 UBA_4 PF14555.6 ORX56292.1 - 0.00044 20.0 0.0 0.0013 18.5 0.0 1.8 2 0 0 2 2 1 1 UBA-like domain zf-C3HC4_2 PF13923.6 ORX56292.1 - 0.001 18.8 10.5 0.0024 17.7 10.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CUE PF02845.16 ORX56292.1 - 0.0057 16.3 0.0 0.017 14.8 0.0 1.8 1 0 0 1 1 1 1 CUE domain SWI2_SNF2 PF18766.1 ORX56292.1 - 0.024 14.3 1.7 0.097 12.3 0.0 2.6 2 1 0 2 2 2 0 SWI2/SNF2 ATPase DEAD_2 PF06733.15 ORX56292.1 - 0.096 12.3 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 DEAD_2 zf-C3HC4_4 PF15227.6 ORX56292.1 - 0.2 11.9 10.6 0.42 10.8 10.6 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ORX56292.1 - 0.22 11.4 5.7 0.73 9.8 5.7 1.9 1 1 1 2 2 2 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ORX56292.1 - 1.2 9.0 9.4 3 7.7 9.4 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RVT PF13966.6 ORX56293.1 - 8.3e-07 29.6 0.0 1e-06 29.4 0.0 1.2 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase AKAP7_NLS PF10469.9 ORX56294.1 - 6.4e-07 29.5 0.0 6.7e-06 26.1 0.0 1.9 1 1 1 2 2 2 1 AKAP7 2'5' RNA ligase-like domain SWIM PF04434.17 ORX56295.1 - 5.8e-05 22.7 0.4 0.00014 21.4 0.4 1.6 1 0 0 1 1 1 1 SWIM zinc finger KcnmB2_inactiv PF09303.10 ORX56296.1 - 0.52 10.1 2.6 0.42 10.5 0.3 1.9 2 0 0 2 2 2 0 KCNMB2, ball and chain domain DUF3450 PF11932.8 ORX56297.1 - 0.011 15.0 6.9 0.015 14.6 6.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ERM PF00769.19 ORX56297.1 - 0.017 15.0 7.7 0.022 14.6 7.7 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family XhlA PF10779.9 ORX56297.1 - 0.072 13.3 2.4 1.1 9.5 0.3 2.7 2 1 1 3 3 3 0 Haemolysin XhlA DUF4200 PF13863.6 ORX56297.1 - 0.089 13.2 3.8 0.14 12.6 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 ORX56297.1 - 0.1 11.5 3.2 0.14 11.1 3.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 ORX56297.1 - 0.28 11.4 2.9 0.51 10.6 2.8 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 ORX56297.1 - 0.36 11.3 2.2 0.48 10.9 1.1 1.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 OmpH PF03938.14 ORX56297.1 - 0.41 11.0 8.5 0.58 10.5 8.5 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) APG6_N PF17675.1 ORX56297.1 - 0.62 10.6 9.0 1.1 9.8 8.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Bac_surface_Ag PF01103.23 ORX56298.1 - 3.3e-47 161.5 0.8 4.3e-47 161.2 0.8 1.1 1 0 0 1 1 1 1 Surface antigen Ribosomal_L19 PF01245.20 ORX56298.1 - 0.032 14.2 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L19 Npa1 PF11707.8 ORX56299.1 - 1.4e-80 271.2 0.3 1.4e-80 271.2 0.3 2.6 3 0 0 3 3 3 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 ORX56299.1 - 6.3e-47 159.8 1.4 3.4e-46 157.4 0.4 2.9 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 SNF2_N PF00176.23 ORX56300.1 - 2.1e-56 191.2 0.0 3.2e-56 190.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 ORX56300.1 - 1.4e-20 74.2 2.6 1e-19 71.4 3.2 2.0 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 ORX56300.1 - 2.1e-17 63.5 0.0 5.8e-17 62.0 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ORX56300.1 - 3.2e-06 26.5 0.1 2.1e-05 23.9 0.0 2.2 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ORX56300.1 - 1.2e-05 25.3 0.0 3.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit gag_pre-integrs PF13976.6 ORX56300.1 - 0.064 13.1 1.5 0.18 11.7 1.5 1.8 1 0 0 1 1 1 0 GAG-pre-integrase domain HicB PF05534.12 ORX56301.1 - 0.094 12.6 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 HicB family NOA36 PF06524.12 ORX56301.1 - 0.18 11.1 4.3 0.28 10.5 4.3 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ORX56301.1 - 5.9 7.3 13.1 12 6.4 13.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TLP-20 PF06088.11 ORX56301.1 - 6.7 6.6 6.7 14 5.6 6.7 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF4611 PF15387.6 ORX56301.1 - 8.2 6.7 12.6 22 5.3 12.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF2796 PF10986.8 ORX56301.1 - 9 6.2 12.2 12 5.8 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) zf-C2H2 PF00096.26 ORX56302.1 - 3.4e-13 49.2 20.4 5.2e-08 32.9 0.9 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX56302.1 - 3e-12 46.4 20.1 1.4e-07 31.6 2.2 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX56302.1 - 4.8e-08 33.2 16.6 1.6e-05 25.3 0.6 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX56302.1 - 0.012 15.6 0.2 0.012 15.6 0.2 3.3 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX56302.1 - 0.013 15.8 4.2 0.019 15.3 4.2 1.3 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ORX56302.1 - 0.015 15.6 11.0 0.38 11.1 0.1 3.6 3 1 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-TRAF PF02176.18 ORX56302.1 - 0.018 15.7 5.9 0.024 15.3 3.7 1.9 1 1 1 2 2 2 0 TRAF-type zinc finger zf-C2H2_aberr PF17017.5 ORX56302.1 - 0.07 13.3 5.1 1.2 9.3 2.2 2.1 1 1 1 2 2 2 0 Aberrant zinc-finger zf_ZIC PF18366.1 ORX56302.1 - 0.68 10.1 0.0 0.68 10.1 0.0 2.7 2 1 1 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_11 PF16622.5 ORX56302.1 - 1.7 8.4 8.0 4.3 7.2 0.3 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-met PF12874.7 ORX56302.1 - 3.6 8.1 9.3 18 5.9 0.0 3.6 3 1 0 3 3 3 0 Zinc-finger of C2H2 type zf-RAG1 PF10426.9 ORX56302.1 - 5.8 7.2 9.0 19 5.5 0.0 3.0 3 1 0 3 3 3 0 Recombination-activating protein 1 zinc-finger domain WD40 PF00400.32 ORX56303.1 - 2.4e-27 94.6 8.9 2.8e-05 24.8 0.1 7.2 7 0 0 7 7 7 4 WD domain, G-beta repeat Sof1 PF04158.14 ORX56303.1 - 5.6e-25 87.4 16.6 9.8e-25 86.7 16.6 1.4 1 0 0 1 1 1 1 Sof1-like domain eIF2A PF08662.11 ORX56303.1 - 2e-07 31.1 1.3 0.00055 19.9 0.0 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ORX56303.1 - 6.8e-06 26.3 0.2 0.021 15.1 0.0 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ORX56303.1 - 0.0019 18.2 0.1 0.47 10.5 0.0 3.1 2 2 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ORX56303.1 - 0.039 13.3 0.3 1.6 7.9 0.0 3.0 3 1 0 3 3 3 0 WD40-like domain Ge1_WD40 PF16529.5 ORX56303.1 - 0.041 12.8 0.1 0.45 9.4 0.0 2.3 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PI3K_p85B PF02192.16 ORX56303.1 - 0.058 13.1 0.1 4.6 7.1 0.0 2.8 2 1 1 3 3 3 0 PI3-kinase family, p85-binding domain RRS1 PF04939.12 ORX56303.1 - 2.8 7.8 8.6 5.9 6.7 8.6 1.4 1 0 0 1 1 1 0 Ribosome biogenesis regulatory protein (RRS1) E1_dh PF00676.20 ORX56304.1 - 9.6e-120 399.1 0.0 1.1e-119 398.8 0.0 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ORX56304.1 - 0.001 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase PQ-loop PF04193.14 ORX56306.1 - 2.2e-35 120.2 14.2 1.3e-18 66.4 2.3 2.8 3 0 0 3 3 3 2 PQ loop repeat Beta_elim_lyase PF01212.21 ORX56307.1 - 1.3e-74 251.1 0.1 1.6e-74 250.9 0.1 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ORX56307.1 - 0.00078 18.8 0.3 0.0019 17.6 0.3 1.8 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ORX56307.1 - 0.013 14.7 0.0 0.034 13.3 0.0 1.6 1 1 0 1 1 1 0 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX56307.1 - 0.11 11.0 0.0 0.2 10.2 0.0 1.4 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme NDK PF00334.19 ORX56308.1 - 5.8e-31 107.3 0.0 7e-31 107.0 0.0 1.1 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glycogen_syn PF05693.13 ORX56312.1 - 0 1061.8 0.0 0 1061.5 0.0 1.1 1 0 0 1 1 1 1 Glycogen synthase Glyco_transf_4 PF13439.6 ORX56312.1 - 3.1e-05 24.0 0.1 6.3e-05 23.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ORX56312.1 - 3.2e-05 23.5 0.0 0.00025 20.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX56312.1 - 0.00067 20.1 0.0 0.026 14.9 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferases group 1 Pkinase PF00069.25 ORX56313.1 - 2.3e-57 194.4 0.0 4.5e-57 193.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56313.1 - 7.3e-28 97.6 0.0 1.1e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX56313.1 - 9.2e-05 23.1 1.1 0.00023 21.8 1.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ORX56313.1 - 0.0004 19.8 0.1 0.0014 18.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ORX56313.1 - 0.0039 16.9 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 MSP7_C PF12948.7 ORX56313.1 - 0.068 13.8 1.2 0.16 12.6 1.2 1.6 1 0 0 1 1 1 0 MSP7-like protein C-terminal domain PX PF00787.24 ORX56313.1 - 0.091 12.8 3.5 0.26 11.3 3.5 1.8 1 0 0 1 1 1 0 PX domain Peptidase_S8 PF00082.22 ORX56314.1 - 2.9e-42 145.0 10.2 4.3e-42 144.4 10.2 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ORX56314.1 - 5.7e-11 42.9 0.0 1.3e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 G10 PF01125.17 ORX56315.1 - 1.3e-70 235.8 1.8 1.5e-70 235.7 1.8 1.0 1 0 0 1 1 1 1 G10 protein Methyltransf_25 PF13649.6 ORX56316.1 - 1e-10 42.2 0.0 2.3e-10 41.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX56316.1 - 3.6e-09 37.2 0.0 9.9e-09 35.7 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX56316.1 - 2.1e-08 34.1 0.0 3.8e-08 33.3 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX56316.1 - 3.4e-06 26.5 0.0 4.5e-06 26.1 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 ORX56316.1 - 0.00035 21.2 0.0 0.00092 19.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX56316.1 - 0.0014 18.5 0.1 0.0037 17.1 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ORX56316.1 - 0.072 12.7 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) HSA PF07529.13 ORX56318.1 - 1.5e-16 60.4 0.3 1.5e-16 60.4 0.3 5.0 5 0 0 5 5 5 1 HSA Myb_DNA-bind_6 PF13921.6 ORX56318.1 - 3e-06 27.4 0.5 3e-06 27.4 0.5 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ORX56318.1 - 0.15 12.3 3.1 0.19 12.0 0.0 2.8 4 0 0 4 4 4 0 SANT/Myb-like domain of DAMP1 LtrA PF06772.11 ORX56319.1 - 1.1e-38 133.3 23.0 1.1e-38 133.3 23.0 1.9 1 1 1 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) Mak10 PF04112.13 ORX56320.1 - 1.8e-51 174.0 4.5 1.3e-50 171.2 0.2 2.6 3 0 0 3 3 3 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DUF3449 PF11931.8 ORX56321.1 - 5.9e-78 260.9 4.5 7.5e-78 260.5 2.4 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 ORX56321.1 - 1.2e-25 89.8 2.0 1.2e-25 89.8 2.0 2.5 3 0 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-met PF12874.7 ORX56321.1 - 4.9e-10 39.5 3.1 4.1e-07 30.2 1.2 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX56321.1 - 2.9e-09 37.0 5.4 4.1e-09 36.5 1.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding SF3a60_bindingd PF12108.8 ORX56321.1 - 0.0012 18.7 0.1 0.0033 17.3 0.1 1.8 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-C2H2_2 PF12756.7 ORX56321.1 - 0.017 15.5 8.0 0.028 14.8 1.0 3.2 3 1 0 3 3 3 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX56321.1 - 0.059 14.2 0.8 14 6.9 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger DUF2175 PF09943.9 ORX56321.1 - 1 9.7 6.9 14 6.1 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) Orthopox_F8 PF05886.11 ORX56322.1 - 0.24 11.6 0.7 4.4 7.5 0.1 2.4 2 0 0 2 2 2 0 Orthopoxvirus F8 protein PEX11 PF05648.14 ORX56323.1 - 5e-32 111.2 0.0 5.7e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) PHD PF00628.29 ORX56324.1 - 2.3e-08 33.8 8.2 4.7e-08 32.8 8.2 1.6 1 0 0 1 1 1 1 PHD-finger zf-RING_2 PF13639.6 ORX56324.1 - 0.64 10.4 9.5 2.9 8.3 9.5 2.2 1 0 0 1 1 1 0 Ring finger domain Lipase_GDSL PF00657.22 ORX56325.1 - 2.3e-09 37.5 0.0 7.3e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX56325.1 - 7.4e-06 26.5 0.1 0.00027 21.4 0.1 2.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Reticulon PF02453.17 ORX56326.1 - 6.7e-19 68.4 5.1 1.3e-18 67.4 4.2 1.8 2 0 0 2 2 2 1 Reticulon TFIIF_alpha PF05793.12 ORX56327.1 - 3.1e-06 26.1 60.3 4.8e-06 25.4 60.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LAP1C PF05609.12 ORX56327.1 - 0.0077 15.4 27.0 0.0089 15.2 27.0 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 ORX56327.1 - 0.039 12.3 41.0 0.055 11.8 41.0 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA_15 PF13175.6 ORX56327.1 - 0.078 12.7 17.4 0.086 12.5 17.4 1.1 1 0 0 1 1 1 0 AAA ATPase domain Macoilin PF09726.9 ORX56327.1 - 0.13 10.8 26.9 0.16 10.5 26.9 1.1 1 0 0 1 1 1 0 Macoilin family DUF2207 PF09972.9 ORX56327.1 - 1.5 7.5 6.0 2.1 7.0 6.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mito_carr PF00153.27 ORX56328.1 - 1.2e-53 179.0 3.5 7.4e-19 67.5 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX56328.1 - 0.0076 15.4 1.2 1.1 8.4 0.1 3.2 2 1 1 3 3 3 2 Gammaproteobacterial serine protease Bac_export_2 PF01312.19 ORX56328.1 - 0.0078 15.5 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 FlhB HrpN YscU SpaS Family NAD_kinase PF01513.21 ORX56329.1 - 3.3e-60 203.8 0.0 5e-60 203.2 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase DUF1645 PF07816.11 ORX56330.1 - 0.036 14.6 9.4 0.087 13.4 9.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1645) Glyco_hydro_31 PF01055.26 ORX56331.1 - 9e-51 173.4 0.5 3.3e-50 171.6 0.5 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ORX56331.1 - 1e-05 25.8 0.4 0.00033 20.9 0.2 3.4 3 1 0 3 3 3 1 Galactose mutarotase-like DASH_Dad4 PF08650.10 ORX56333.1 - 5.2e-18 64.8 0.7 3e-08 33.5 0.2 2.0 1 1 1 2 2 2 2 DASH complex subunit Dad4 DUF905 PF06006.12 ORX56333.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) ABC_membrane PF00664.23 ORX56336.1 - 9.3e-52 176.4 26.0 5.7e-28 98.3 14.9 2.5 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX56336.1 - 2.5e-50 170.6 0.0 2.1e-28 99.5 0.0 2.7 2 1 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX56336.1 - 7.4e-11 41.9 0.1 0.00039 19.9 0.1 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ORX56336.1 - 1e-06 29.1 1.1 0.14 12.4 0.0 3.6 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX56336.1 - 1.1e-06 27.9 0.0 0.013 14.5 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_29 PF13555.6 ORX56336.1 - 1.1e-06 28.2 0.1 0.078 12.7 0.0 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX56336.1 - 2e-06 28.4 0.7 0.0011 19.6 0.1 2.7 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.6 ORX56336.1 - 4.3e-05 23.5 0.0 0.91 9.3 0.0 3.3 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system FtsK_SpoIIIE PF01580.18 ORX56336.1 - 7.5e-05 22.2 0.0 0.073 12.4 0.0 2.6 2 0 0 2 2 2 2 FtsK/SpoIIIE family IstB_IS21 PF01695.17 ORX56336.1 - 9.4e-05 22.2 0.1 0.47 10.2 0.0 3.2 4 0 0 4 4 3 2 IstB-like ATP binding protein AAA_16 PF13191.6 ORX56336.1 - 0.00015 22.2 0.0 0.76 10.1 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 ORX56336.1 - 0.0002 21.0 0.4 0.14 11.7 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 ORX56336.1 - 0.0012 18.6 1.9 0.089 12.5 0.3 3.2 2 1 0 2 2 2 1 AAA domain AAA_15 PF13175.6 ORX56336.1 - 0.0015 18.3 0.0 0.64 9.7 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ORX56336.1 - 0.0016 18.4 0.0 0.25 11.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 ORX56336.1 - 0.0027 17.2 0.0 1.6 8.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region Dynamin_N PF00350.23 ORX56336.1 - 0.0029 17.7 0.1 0.41 10.7 0.0 2.6 2 0 0 2 2 2 1 Dynamin family AAA_33 PF13671.6 ORX56336.1 - 0.0029 17.8 1.7 1.4 9.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ORX56336.1 - 0.003 18.1 0.2 1.7 9.2 0.1 3.0 2 1 0 2 2 2 1 AAA domain DEAD PF00270.29 ORX56336.1 - 0.0039 17.0 0.1 5 6.9 0.0 2.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA PF00004.29 ORX56336.1 - 0.0068 16.8 0.3 1.8 9.0 0.0 3.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ORX56336.1 - 0.0084 15.5 0.0 4.1 6.7 0.0 2.4 2 0 0 2 2 2 1 KaiC RNA_helicase PF00910.22 ORX56336.1 - 0.016 15.6 0.4 13 6.2 0.0 3.3 3 0 0 3 3 3 0 RNA helicase DUF87 PF01935.17 ORX56336.1 - 0.026 14.6 1.0 0.32 11.1 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain ResIII PF04851.15 ORX56336.1 - 0.028 14.4 0.1 7 6.6 0.0 3.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit MMR_HSR1 PF01926.23 ORX56336.1 - 0.032 14.3 0.1 13 5.9 0.0 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ORX56336.1 - 0.044 13.5 0.2 22 4.7 0.1 3.1 2 1 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ORX56336.1 - 0.061 12.5 0.3 2.6 7.2 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Zeta_toxin PF06414.12 ORX56336.1 - 0.062 12.6 0.0 12 5.1 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin FKBP_N_2 PF18023.1 ORX56336.1 - 0.14 12.3 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 BDBT FKBP like N-terminal NACHT PF05729.12 ORX56336.1 - 0.17 11.8 0.5 24 4.8 0.1 2.6 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 ORX56336.1 - 0.22 10.7 1.4 2.1 7.5 0.1 2.8 2 1 0 2 2 2 0 NB-ARC domain DUF3917 PF13055.6 ORX56336.1 - 0.54 10.7 5.2 0.66 10.5 1.5 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF3917) cobW PF02492.19 ORX56336.1 - 0.61 9.6 1.8 1.1 8.8 0.2 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SAYSvFN PF10260.9 ORX56336.1 - 4.4 7.3 23.0 0.46 10.4 1.4 4.9 4 0 0 4 4 4 0 Uncharacterized conserved domain (SAYSvFN) DUF2009 PF09418.10 ORX56337.1 - 1.2e-209 697.1 0.0 1.4e-209 696.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) SPO22 PF08631.10 ORX56337.1 - 0.087 12.3 0.0 2.2 7.7 0.0 2.3 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DEAD PF00270.29 ORX56338.1 - 6.1e-51 172.7 0.0 1.3e-50 171.6 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX56338.1 - 1.5e-33 115.4 0.1 5.8e-29 100.7 0.1 3.3 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ORX56338.1 - 0.00015 21.1 0.0 0.00015 21.1 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 ORX56338.1 - 0.0076 15.6 10.2 0.16 11.3 0.0 2.5 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 ORX56338.1 - 0.12 12.7 0.4 1.8 8.9 0.0 2.6 2 1 0 2 2 2 0 AAA domain TAF4 PF05236.14 ORX56338.1 - 0.3 10.8 9.1 0.54 10.0 9.1 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Ferlin_C PF16165.5 ORX56338.1 - 1.6 8.7 5.1 1.7 8.6 3.0 2.1 2 0 0 2 2 2 0 Ferlin C-terminus RNA_polI_A34 PF08208.11 ORX56338.1 - 7.1 6.7 17.1 14 5.7 17.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Myb_DNA-binding PF00249.31 ORX56339.1 - 2.5e-05 24.4 0.0 6.6e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX56339.1 - 0.0078 16.4 1.0 0.035 14.3 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF382 PF04037.13 ORX56339.1 - 0.023 14.9 3.9 0.034 14.3 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF382) PsaD PF02531.16 ORX56339.1 - 0.11 12.0 0.2 0.17 11.4 0.2 1.3 1 0 0 1 1 1 0 PsaD FlgM PF04316.13 ORX56339.1 - 0.22 11.9 3.3 0.59 10.5 3.3 1.9 1 1 0 1 1 1 0 Anti-sigma-28 factor, FlgM Ras PF00071.22 ORX56340.1 - 5.7e-44 149.6 0.0 6.6e-44 149.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX56340.1 - 8.2e-20 71.2 0.0 1.2e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX56340.1 - 1.5e-06 27.8 0.0 1.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX56340.1 - 0.0013 18.1 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX56340.1 - 0.002 18.2 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX56340.1 - 0.0033 17.3 0.0 1.2 9.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX56340.1 - 0.0037 17.7 0.1 0.0056 17.1 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 ORX56340.1 - 0.011 15.3 0.1 0.15 11.6 0.0 2.3 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX56340.1 - 0.019 15.3 0.0 0.058 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ORX56340.1 - 0.036 13.2 0.2 0.34 10.1 0.1 2.0 1 1 1 2 2 2 0 NB-ARC domain NACHT PF05729.12 ORX56340.1 - 0.063 13.2 0.0 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 NACHT domain Septin PF00735.18 ORX56340.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Septin FAD_binding_7 PF03441.14 ORX56340.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain of DNA photolyase ATPase_2 PF01637.18 ORX56340.1 - 0.13 12.1 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea TniB PF05621.11 ORX56340.1 - 0.15 11.4 0.0 0.22 10.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Ufd2P_core PF10408.9 ORX56341.1 - 7.5e-184 612.8 8.0 7.5e-184 612.8 8.0 1.6 2 0 0 2 2 2 1 Ubiquitin elongating factor core U-box PF04564.15 ORX56341.1 - 3.2e-19 68.9 0.1 1.1e-18 67.2 0.1 2.0 1 0 0 1 1 1 1 U-box domain Fes1 PF08609.10 ORX56341.1 - 4.9 8.1 12.4 29 5.6 0.0 5.3 5 0 0 5 5 5 0 Nucleotide exchange factor Fes1 CoaE PF01121.20 ORX56342.1 - 3.6e-60 202.7 0.0 4.3e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ORX56342.1 - 1.3e-05 25.8 0.0 3.3e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX56342.1 - 0.013 15.7 0.0 0.036 14.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX56342.1 - 0.058 13.6 0.0 0.18 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ORX56342.1 - 0.19 11.0 0.7 0.24 10.7 0.0 1.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family DHFR_1 PF00186.19 ORX56343.1 - 1.6e-40 138.5 0.0 2.1e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 Dihydrofolate reductase Gp_dh_C PF02800.20 ORX56345.1 - 3.4e-70 234.7 0.0 7.7e-70 233.5 0.0 1.6 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ORX56345.1 - 4.9e-40 135.9 0.2 1.7e-39 134.2 0.1 2.0 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX56345.1 - 0.0053 16.9 0.0 0.025 14.7 0.0 2.1 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Flavoprotein PF02441.19 ORX56345.1 - 0.05 13.4 0.1 0.075 12.8 0.1 1.3 1 0 0 1 1 1 0 Flavoprotein NUDIX PF00293.28 ORX56347.1 - 1.2e-09 38.3 0.1 1.4e-09 38.1 0.1 1.0 1 0 0 1 1 1 1 NUDIX domain DUF4710 PF15828.5 ORX56347.1 - 1.1 9.4 4.6 1.9 8.7 4.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) EMG1 PF03587.14 ORX56348.1 - 9.5e-68 227.7 0.0 1.1e-67 227.4 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Fer2 PF00111.27 ORX56349.1 - 5.9e-11 42.2 4.1 8.2e-11 41.7 4.1 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Mitoc_L55 PF09776.9 ORX56349.1 - 0.13 12.0 0.0 0.32 10.8 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L55 SMK-1 PF04802.15 ORX56350.1 - 1.5e-51 175.0 5.3 1.5e-51 175.0 5.3 1.9 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 ORX56350.1 - 0.0019 18.1 0.1 0.0045 16.9 0.1 1.6 1 0 0 1 1 1 1 WH1 domain CPSF100_C PF13299.6 ORX56351.1 - 0.14 12.4 1.6 0.29 11.3 1.6 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Esterase PF00756.20 ORX56352.1 - 1.8e-55 188.3 0.1 2.1e-55 188.1 0.1 1.0 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ORX56352.1 - 1.2e-06 28.2 0.1 1.6e-06 27.8 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 ORX56352.1 - 2.3e-06 26.7 0.0 3.4e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 ORX56352.1 - 0.00012 21.4 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX56352.1 - 0.0033 18.1 0.0 0.0055 17.3 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 ORX56352.1 - 0.0073 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase PF07224.11 ORX56352.1 - 0.012 14.6 0.0 0.12 11.3 0.0 2.0 2 0 0 2 2 2 0 Chlorophyllase PGAP1 PF07819.13 ORX56352.1 - 0.012 15.3 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_2 PF02230.16 ORX56352.1 - 0.015 15.1 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase PAF-AH_p_II PF03403.13 ORX56352.1 - 0.042 12.4 0.0 0.064 11.8 0.0 1.2 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Esterase_phd PF10503.9 ORX56352.1 - 0.05 13.1 0.0 0.32 10.4 0.0 1.9 2 0 0 2 2 2 0 Esterase PHB depolymerase Abhydrolase_3 PF07859.13 ORX56352.1 - 0.064 13.1 0.0 0.094 12.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF676 PF05057.14 ORX56352.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) 4HBT PF03061.22 ORX56353.1 - 3.9e-09 36.7 0.0 6.5e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily DUF4442 PF14539.6 ORX56353.1 - 0.0011 19.1 0.0 0.0013 18.9 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) Auxin_BP PF02041.16 ORX56355.1 - 0.072 12.7 0.0 0.083 12.5 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein DUF3245 PF11595.8 ORX56356.1 - 3.5e-08 34.0 16.0 2.1e-07 31.5 15.3 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF3245) DUF2576 PF10845.8 ORX56357.1 - 0.12 11.9 0.0 0.23 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) EHN PF06441.12 ORX56358.1 - 2.5e-27 95.3 0.7 6.1e-27 94.1 0.7 1.7 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ORX56358.1 - 1.5e-15 57.6 0.1 2.8e-15 56.7 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX56358.1 - 6.9e-07 30.1 1.1 2.4e-06 28.3 1.1 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family Acyl-CoA_dh_1 PF00441.24 ORX56359.1 - 2e-48 164.4 5.9 3e-48 163.8 5.9 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX56359.1 - 6.7e-28 97.6 0.1 1.6e-27 96.4 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ORX56359.1 - 4.5e-27 94.1 0.2 1.4e-26 92.5 0.2 1.9 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX56359.1 - 7.4e-19 68.4 3.8 1.3e-18 67.6 3.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ORX56359.1 - 1.5e-05 24.8 0.6 4.3e-05 23.3 0.6 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Mor PF08765.11 ORX56359.1 - 0.13 12.3 0.1 0.36 10.8 0.1 1.7 1 0 0 1 1 1 0 Mor transcription activator family zf-C2H2_2 PF12756.7 ORX56364.1 - 0.0003 21.1 1.5 0.00084 19.6 1.5 1.7 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX56364.1 - 0.00063 20.4 9.2 0.19 12.6 0.7 2.6 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX56364.1 - 0.0083 15.9 2.8 0.0083 15.9 2.8 2.1 2 1 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2 PF00096.26 ORX56364.1 - 0.014 15.8 12.1 0.71 10.5 5.0 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_3rep PF18868.1 ORX56364.1 - 0.014 16.0 2.9 0.7 10.6 0.3 2.1 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats GAGA PF09237.11 ORX56364.1 - 0.076 12.8 1.3 0.32 10.8 0.5 2.3 2 0 0 2 2 2 0 GAGA factor zf-C2H2_6 PF13912.6 ORX56364.1 - 0.14 12.2 11.3 1.4 9.0 1.2 2.5 2 1 0 2 2 2 0 C2H2-type zinc finger FOXP-CC PF16159.5 ORX56364.1 - 0.17 12.5 2.4 5.1 7.8 0.2 2.2 2 0 0 2 2 2 0 FOXP coiled-coil domain zf_Hakai PF18408.1 ORX56364.1 - 0.68 9.7 4.4 1.1 9.1 2.6 2.0 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-Di19 PF05605.12 ORX56364.1 - 0.7 10.2 8.2 0.37 11.1 2.5 2.2 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.12 ORX56364.1 - 0.9 8.0 3.5 3.3 6.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF629) Acyl-CoA_dh_1 PF00441.24 ORX56365.1 - 5.4e-48 163.0 5.1 6.6e-48 162.7 5.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX56365.1 - 5.5e-19 68.8 4.0 8.1e-19 68.2 4.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Mor PF08765.11 ORX56365.1 - 0.011 15.8 0.2 0.079 13.0 0.1 2.2 2 0 0 2 2 2 0 Mor transcription activator family Tam41_Mmp37 PF09139.11 ORX56366.1 - 4e-124 414.3 0.1 5.9e-124 413.7 0.1 1.2 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial VIR_N PF15912.5 ORX56366.1 - 6.5e-05 22.7 0.7 9.9e-05 22.1 0.7 1.2 1 0 0 1 1 1 1 Virilizer, N-terminal CAP_N PF01213.19 ORX56366.1 - 0.19 11.2 2.9 0.37 10.2 2.9 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ribosomal_S14 PF00253.21 ORX56367.1 - 8.1e-17 60.7 2.0 9.3e-17 60.5 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DnaJ PF00226.31 ORX56368.1 - 2.5e-18 65.9 1.2 2.5e-18 65.9 1.2 1.5 2 0 0 2 2 2 1 DnaJ domain dCMP_cyt_deam_1 PF00383.23 ORX56369.1 - 2.8e-16 59.2 0.0 3.4e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 ORX56369.1 - 1.4e-09 38.3 0.0 2.3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 ORX56369.1 - 0.0086 15.7 0.2 0.2 11.2 0.0 2.0 1 1 1 2 2 2 1 A distinct subfamily of CDD/CDA-like deaminases ERCC3_RAD25_C PF16203.5 ORX56370.1 - 5.5e-125 415.5 0.6 1e-124 414.7 0.6 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 ORX56370.1 - 2.3e-37 128.0 0.0 6.8e-37 126.4 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX56370.1 - 2.1e-16 60.4 0.0 5.2e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX56370.1 - 4e-11 43.2 0.0 1.5e-10 41.4 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ORX56370.1 - 3.6e-09 35.8 0.0 5e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 ORX56370.1 - 0.00023 21.0 0.0 0.00051 19.9 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Ribosomal_S7e PF01251.18 ORX56371.1 - 7.4e-86 286.6 3.1 8.3e-86 286.5 3.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Complex1_49kDa PF00346.19 ORX56372.1 - 1.1e-119 398.5 0.0 1.7e-119 397.9 0.0 1.3 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 ORX56372.1 - 0.00077 18.5 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Nickel-dependent hydrogenase Cys_Met_Meta_PP PF01053.20 ORX56373.1 - 1.5e-131 438.5 0.2 1.7e-131 438.3 0.2 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX56373.1 - 1.4e-08 34.3 0.2 3.4e-08 33.0 0.2 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ORX56373.1 - 4e-08 32.6 0.5 9.8e-08 31.3 0.1 1.7 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 ORX56373.1 - 2.1e-06 27.3 0.2 3.7e-06 26.5 0.1 1.3 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 ORX56373.1 - 0.038 13.3 0.4 0.099 11.9 0.4 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase Rad10 PF03834.14 ORX56374.1 - 3.3e-44 149.5 0.1 5.3e-44 148.9 0.1 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_5 PF14520.6 ORX56374.1 - 0.011 16.3 0.0 0.019 15.6 0.0 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix domain Pkinase PF00069.25 ORX56375.1 - 1.8e-61 207.8 0.0 2.6e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56375.1 - 8.5e-32 110.4 0.0 1.2e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX56375.1 - 2.7e-09 36.8 0.0 4.2e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 ORX56375.1 - 5.1e-06 27.1 2.0 1.4e-05 25.7 0.8 2.5 2 1 0 2 2 2 1 Protein kinase C terminal domain PX PF00787.24 ORX56375.1 - 5e-05 23.2 0.1 0.00018 21.5 0.0 2.0 2 0 0 2 2 2 1 PX domain FTA2 PF13095.6 ORX56375.1 - 6.1e-05 22.7 0.0 0.35 10.4 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX56375.1 - 0.0018 17.3 0.4 0.0027 16.7 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX56375.1 - 0.062 12.7 0.2 0.11 11.8 0.2 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC_tran PF00005.27 ORX56376.1 - 0.0018 18.8 0.1 0.0031 18.0 0.1 1.4 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 ORX56376.1 - 0.0053 16.9 0.0 0.0083 16.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX56376.1 - 0.0097 16.3 0.0 0.016 15.6 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ORX56376.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ORX56376.1 - 0.011 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_25 PF13481.6 ORX56376.1 - 0.066 12.8 0.0 0.12 11.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX56376.1 - 0.08 12.8 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ORX56376.1 - 0.12 12.7 0.0 0.32 11.3 0.0 1.7 2 1 0 2 2 2 0 AAA domain ATPase PF06745.13 ORX56376.1 - 0.12 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 KaiC AAA_24 PF13479.6 ORX56376.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_S8 PF00082.22 ORX56377.1 - 2.4e-41 142.0 4.5 3.7e-41 141.3 4.5 1.2 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 ORX56377.1 - 1.2e-16 61.1 0.5 2.6e-16 60.0 0.5 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 SNAPc_SNAP43 PF09808.9 ORX56378.1 - 6.2e-25 88.3 8.5 8.7e-25 87.8 8.5 1.2 1 0 0 1 1 1 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 zf-C2H2_4 PF13894.6 ORX56379.1 - 0.0031 18.2 5.1 1.4 9.9 0.1 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX56379.1 - 0.028 14.9 1.7 1.1 9.8 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain CpXC PF14353.6 ORX56379.1 - 0.049 13.7 0.5 9 6.4 0.1 2.7 2 0 0 2 2 2 0 CpXC protein zf-C2H2 PF00096.26 ORX56379.1 - 0.09 13.3 9.3 0.59 10.7 0.2 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 ORX56379.1 - 0.21 11.9 0.2 0.21 11.9 0.2 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf_UBZ PF18439.1 ORX56379.1 - 0.78 9.4 7.1 0.56 9.8 0.1 2.8 2 1 0 2 2 2 0 Ubiquitin-Binding Zinc Finger HSP90 PF00183.18 ORX56380.1 - 7.4e-106 355.1 3.1 3.3e-102 343.0 0.7 2.1 1 1 1 2 2 2 2 Hsp90 protein HATPase_c_3 PF13589.6 ORX56380.1 - 1.3e-11 44.4 0.7 3.1e-11 43.2 0.1 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX56380.1 - 8.6e-08 32.7 0.1 2.2e-07 31.4 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF5491 PF17595.2 ORX56380.1 - 0.066 13.5 0.1 0.2 12.0 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5491) HATPase_c_2 PF13581.6 ORX56380.1 - 0.1 12.6 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Synaptobrevin PF00957.21 ORX56381.1 - 1e-25 89.3 0.6 1.1e-25 89.2 0.6 1.0 1 0 0 1 1 1 1 Synaptobrevin Fzo_mitofusin PF04799.13 ORX56381.1 - 0.063 12.8 0.1 0.075 12.6 0.1 1.1 1 0 0 1 1 1 0 fzo-like conserved region MCU PF04678.13 ORX56381.1 - 0.063 13.4 0.0 0.072 13.2 0.0 1.0 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3926 PF13080.6 ORX56381.1 - 0.25 11.3 1.7 0.26 11.2 0.0 1.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3926) CTD_bind PF04818.13 ORX56382.1 - 2.7e-08 34.5 0.0 1e-07 32.7 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 ORX56382.1 - 0.0024 18.3 1.3 0.008 16.6 0.0 2.4 2 1 1 3 3 3 1 Subunit of cleavage factor IA Pcf11 zf-C2H2_4 PF13894.6 ORX56382.1 - 0.038 14.8 0.9 20 6.3 0.1 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger CTK3 PF12243.8 ORX56382.1 - 0.17 11.9 0.2 0.3 11.1 0.2 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 MR_MLE_C PF13378.6 ORX56385.1 - 6.1e-57 192.7 0.0 1.1e-56 191.8 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ORX56385.1 - 1.2e-07 32.0 0.0 2.4e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain ComA PF02679.15 ORX56385.1 - 0.14 11.5 0.2 1.1 8.7 0.0 2.0 2 0 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) Exo_endo_phos PF03372.23 ORX56386.1 - 1.6e-05 24.6 0.1 2.7e-05 23.8 0.1 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Arrestin_C PF02752.22 ORX56387.1 - 6.7e-10 39.5 0.8 4.1e-09 37.0 0.8 2.0 1 1 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Spo0M PF07070.11 ORX56387.1 - 0.066 12.8 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 SpoOM protein RNF220 PF15926.5 ORX56388.1 - 6.2e-26 91.5 1.1 1.3e-25 90.5 1.1 1.6 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-C3HC4_2 PF13923.6 ORX56388.1 - 2.9e-11 43.0 11.1 2.9e-11 43.0 11.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX56388.1 - 6e-05 22.9 8.7 6e-05 22.9 8.7 2.2 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX56388.1 - 0.00032 20.5 13.2 0.00097 19.0 8.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX56388.1 - 0.00034 20.9 11.5 0.00034 20.9 11.5 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ORX56388.1 - 0.00049 19.9 10.6 0.00049 19.9 10.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX56388.1 - 0.0077 16.3 6.5 0.0078 16.2 2.5 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX56388.1 - 0.016 15.2 9.8 0.016 15.2 9.8 2.1 2 0 0 2 2 2 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX56388.1 - 0.02 14.7 7.8 0.02 14.7 7.8 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ORX56388.1 - 0.06 13.2 5.6 0.13 12.1 5.6 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit FYDLN_acid PF09538.10 ORX56388.1 - 0.33 11.7 10.5 4.4 8.0 4.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Endonuclease_7 PF02945.15 ORX56388.1 - 0.47 10.4 5.5 1.7 8.6 1.5 2.3 2 0 0 2 2 2 0 Recombination endonuclease VII TackOD1 PF18551.1 ORX56388.1 - 0.52 10.0 7.6 5.5 6.6 4.5 2.3 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 SUIM_assoc PF16619.5 ORX56388.1 - 0.68 10.0 2.7 0.5 10.5 0.5 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-RING_6 PF14835.6 ORX56388.1 - 1.8 8.5 6.6 0.24 11.3 2.1 1.8 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING-like PF08746.11 ORX56388.1 - 7.1 7.0 10.5 2.1 8.7 6.3 2.2 2 0 0 2 2 2 0 RING-like domain zf-C3HC4_4 PF15227.6 ORX56388.1 - 7.2 6.9 13.7 2.2 8.5 10.4 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Mg_trans_NIPA PF05653.14 ORX56390.1 - 4.8e-97 324.6 21.3 6.1e-97 324.3 21.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX56390.1 - 0.00021 21.5 7.1 0.00021 21.5 7.1 3.8 3 1 0 3 3 3 2 EamA-like transporter family DUF1751 PF08551.10 ORX56390.1 - 0.039 14.5 1.5 0.039 14.5 1.5 2.8 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) Tmemb_161AB PF10268.9 ORX56390.1 - 1 7.9 13.5 0.02 13.6 6.4 1.6 2 0 0 2 2 2 0 Predicted transmembrane protein 161AB Cofilin_ADF PF00241.20 ORX56391.1 - 7.7e-10 38.6 0.0 2.8e-09 36.8 0.0 2.0 2 0 0 2 2 2 1 Cofilin/tropomyosin-type actin-binding protein PH PF00169.29 ORX56391.1 - 0.03 14.8 0.0 0.064 13.8 0.0 1.6 1 0 0 1 1 1 0 PH domain FAD_binding_1 PF00667.20 ORX56392.1 - 1.2e-51 175.4 0.0 1.8e-51 174.9 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX56392.1 - 5.6e-31 107.7 0.4 1.1e-30 106.7 0.4 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX56392.1 - 5.8e-20 72.0 0.0 1.9e-19 70.3 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Sec61_beta PF03911.16 ORX56393.1 - 5.8e-18 64.7 0.8 6.3e-18 64.5 0.8 1.0 1 0 0 1 1 1 1 Sec61beta family Glycogen_syn PF05693.13 ORX56394.1 - 0 1085.3 0.0 0 1085.0 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 ORX56394.1 - 6.6e-07 29.0 0.0 0.0005 19.7 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 ORX56394.1 - 2.2e-06 27.6 0.1 6.1e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Starch synthase catalytic domain Glyco_trans_1_4 PF13692.6 ORX56394.1 - 2.5e-05 24.7 0.0 0.005 17.3 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX56394.1 - 0.00021 21.3 0.1 0.00045 20.2 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX56394.1 - 0.0014 19.1 0.0 0.0031 18.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Spore_YhcN_YlaJ PF09580.10 ORX56396.1 - 0.066 13.3 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) 2-Hacid_dh_C PF02826.19 ORX56397.1 - 2.3e-46 157.4 0.0 4.9e-46 156.3 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ORX56397.1 - 4.5e-36 123.5 0.0 6.5e-36 123.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ORX56397.1 - 7e-05 23.0 0.5 0.00024 21.3 0.2 2.0 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ACT PF01842.25 ORX56397.1 - 0.019 14.8 0.0 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 ACT domain Abhydrolase_1 PF00561.20 ORX56398.1 - 4.8e-51 173.9 0.0 9.2e-51 172.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX56398.1 - 0.0078 16.8 0.5 0.01 16.5 0.5 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family SCP2 PF02036.17 ORX56399.1 - 5.2e-24 84.7 2.8 6.3e-24 84.4 2.8 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ORX56399.1 - 0.0048 17.2 0.3 0.0071 16.6 0.3 1.3 1 1 0 1 1 1 1 Alkyl sulfatase C-terminal DUF3700 PF12481.8 ORX56399.1 - 0.067 12.6 0.0 0.085 12.3 0.0 1.1 1 0 0 1 1 1 0 Aluminium induced protein Toxin_20 PF08089.11 ORX56399.1 - 0.088 12.9 0.2 0.13 12.4 0.2 1.5 1 1 0 1 1 1 0 Huwentoxin-II family Nuc_sug_transp PF04142.15 ORX56400.1 - 4.7e-98 328.2 25.1 1.8e-62 211.3 8.6 2.0 2 0 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 ORX56400.1 - 9e-05 21.8 16.9 0.0011 18.2 16.9 2.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX56400.1 - 0.00028 21.1 8.0 0.00028 21.1 8.0 4.0 3 1 1 4 4 4 1 EamA-like transporter family Kelch_5 PF13854.6 ORX56401.1 - 4.6e-19 68.0 1.0 0.0023 17.9 0.1 5.7 5 0 0 5 5 5 4 Kelch motif Kelch_3 PF13415.6 ORX56401.1 - 2.4e-13 50.0 12.7 4.9e-05 23.5 0.0 6.4 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX56401.1 - 5.1e-13 48.8 11.7 0.055 13.8 0.0 6.7 6 0 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ORX56401.1 - 1.9e-07 31.0 17.6 0.0089 16.0 0.0 6.0 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX56401.1 - 5.8e-06 25.8 11.9 0.21 11.2 0.1 6.2 5 1 0 5 5 5 2 Kelch motif RAG2 PF03089.14 ORX56401.1 - 0.035 13.1 0.0 0.11 11.5 0.0 1.6 1 1 1 2 2 2 0 Recombination activating protein 2 Kelch_2 PF07646.15 ORX56401.1 - 0.087 12.8 7.7 7.4 6.7 0.0 5.5 7 1 0 7 7 7 0 Kelch motif FeoB_associated PF12669.7 ORX56401.1 - 0.21 12.0 0.2 0.45 11.0 0.2 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Peptidase_U4 PF03419.13 ORX56402.1 - 0.0026 17.1 0.0 0.0033 16.8 0.0 1.1 1 0 0 1 1 1 1 Sporulation factor SpoIIGA TraS PF10624.9 ORX56402.1 - 6 6.8 5.1 1.9 8.4 0.7 2.2 2 1 1 3 3 3 0 Plasmid conjugative transfer entry exclusion protein TraS Exo_endo_phos PF03372.23 ORX56403.1 - 2.5e-19 69.7 0.0 3.2e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX56403.1 - 0.00079 19.3 0.0 0.014 15.2 0.0 2.4 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Thiolase_N PF00108.23 ORX56404.1 - 1.4e-79 267.2 4.7 2.1e-77 260.0 4.2 2.0 2 0 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ORX56404.1 - 3.4e-45 152.7 0.1 8.1e-45 151.4 0.1 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain PspC PF04024.12 ORX56404.1 - 0.038 13.8 0.0 0.077 12.8 0.0 1.5 1 0 0 1 1 1 0 PspC domain ALAD PF00490.21 ORX56405.1 - 1.3e-119 399.1 0.0 1.5e-119 398.9 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Exo_endo_phos PF03372.23 ORX56406.1 - 1.1e-07 31.6 1.4 1.7e-07 31.0 1.4 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family XPC-binding PF09280.11 ORX56407.1 - 0.075 12.8 0.3 0.14 11.9 0.3 1.4 1 0 0 1 1 1 0 XPC-binding domain F-box-like PF12937.7 ORX56408.1 - 0.00024 20.9 0.9 0.00048 20.0 0.1 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX56408.1 - 0.0071 16.2 0.6 0.024 14.5 0.6 1.9 1 0 0 1 1 1 1 F-box domain PP2C PF00481.21 ORX56409.1 - 5.5e-53 180.2 0.1 1.7e-52 178.6 0.0 1.8 2 0 0 2 2 2 1 Protein phosphatase 2C LRR_8 PF13855.6 ORX56409.1 - 1.6e-42 143.0 60.5 4.8e-09 35.9 4.8 11.0 7 3 6 13 13 13 9 Leucine rich repeat LRR_4 PF12799.7 ORX56409.1 - 5.1e-37 125.3 62.7 0.00018 21.8 0.8 12.4 6 3 7 14 14 14 14 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 ORX56409.1 - 4.5e-31 107.9 0.0 1e-30 106.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RA PF00788.23 ORX56409.1 - 5.6e-06 26.9 0.0 1.7e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain LRR_9 PF14580.6 ORX56409.1 - 7.9e-06 25.5 21.9 0.0031 17.0 1.2 6.0 6 0 0 6 6 6 3 Leucine-rich repeat LRR_1 PF00560.33 ORX56409.1 - 0.0014 18.9 54.3 1.2 10.0 0.3 15.3 17 3 0 17 17 17 3 Leucine Rich Repeat LRR_5 PF13306.6 ORX56409.1 - 0.025 14.6 3.2 0.39 10.7 0.0 3.4 2 2 2 4 4 4 0 BspA type Leucine rich repeat region (6 copies) Pkinase PF00069.25 ORX56410.1 - 9.7e-57 192.3 0.0 2.2e-56 191.1 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56410.1 - 5.3e-44 150.4 0.0 8.6e-44 149.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX56410.1 - 2.4e-06 26.6 0.0 4.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX56410.1 - 6.6e-05 22.4 0.0 0.00031 20.2 0.0 2.0 2 0 0 2 2 2 1 Kinase-like FH2 PF02181.23 ORX56410.1 - 0.015 14.5 0.8 0.024 13.8 0.8 1.3 1 0 0 1 1 1 0 Formin Homology 2 Domain Cep57_CLD_2 PF14197.6 ORX56410.1 - 0.05 13.7 4.4 0.16 12.0 4.4 1.9 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 APH PF01636.23 ORX56410.1 - 0.17 11.8 1.0 0.48 10.3 0.1 2.2 2 1 0 3 3 3 0 Phosphotransferase enzyme family YabA PF06156.13 ORX56410.1 - 0.28 11.8 1.7 0.74 10.5 1.7 1.8 1 0 0 1 1 1 0 Initiation control protein YabA Shugoshin_N PF07558.11 ORX56410.1 - 0.3 11.0 4.1 0.91 9.4 1.3 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region APC_N_CC PF16689.5 ORX56410.1 - 0.56 10.3 5.1 8.9 6.5 1.7 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain DivIC PF04977.15 ORX56410.1 - 2.8 7.8 11.0 1.2 9.0 7.6 2.1 1 1 1 2 2 2 0 Septum formation initiator Ribosomal_L1 PF00687.21 ORX56413.1 - 4.3e-28 98.4 2.0 4.3e-28 98.4 2.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L1p/L10e family PALP PF00291.25 ORX56414.1 - 7.8e-71 238.9 0.7 9.1e-71 238.7 0.7 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3343 PF11823.8 ORX56414.1 - 0.039 13.4 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) CSN8_PSD8_EIF3K PF10075.9 ORX56415.1 - 8.5e-31 106.9 0.9 1.2e-30 106.4 0.9 1.3 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 ORX56415.1 - 0.08 12.3 0.4 0.14 11.6 0.4 1.3 1 0 0 1 1 1 0 SAC3/GANP family NAM PF02365.15 ORX56415.1 - 0.16 12.9 0.0 0.24 12.3 0.0 1.4 1 0 0 1 1 1 0 No apical meristem (NAM) protein Ctr PF04145.15 ORX56417.1 - 1.6e-33 116.5 4.9 2.3e-33 115.9 4.9 1.2 1 0 0 1 1 1 1 Ctr copper transporter family Neurensin PF14927.6 ORX56417.1 - 0.11 12.2 2.5 0.67 9.7 0.2 2.1 1 1 1 2 2 2 0 Neurensin DUF3099 PF11298.8 ORX56417.1 - 1.5 9.0 5.5 0.42 10.8 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) 2OG-FeII_Oxy PF03171.20 ORX56418.1 - 1.8e-19 70.1 0.0 4.7e-19 68.8 0.0 1.6 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily FHA PF00498.26 ORX56419.1 - 7.8e-15 55.0 0.1 1.9e-14 53.7 0.1 1.7 1 1 1 2 2 2 1 FHA domain zf-RING_11 PF17123.5 ORX56419.1 - 1.6e-11 43.7 9.2 3.2e-11 42.8 9.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX56419.1 - 3.4e-08 33.7 10.3 5.4e-08 33.0 10.3 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX56419.1 - 0.001 18.9 11.7 0.0017 18.2 11.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX56419.1 - 0.0029 17.6 8.9 0.0054 16.7 8.9 1.5 1 0 0 1 1 1 1 zinc-RING finger domain Yop-YscD_cpl PF16697.5 ORX56419.1 - 0.0053 17.1 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 ORX56419.1 - 0.0088 15.9 9.8 0.015 15.1 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX56419.1 - 0.0088 16.3 7.3 0.017 15.4 7.3 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain PHD PF00628.29 ORX56419.1 - 0.06 13.2 6.4 0.11 12.4 6.4 1.5 1 0 0 1 1 1 0 PHD-finger zf-ANAPC11 PF12861.7 ORX56419.1 - 0.086 12.9 3.3 0.14 12.2 3.3 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ORX56419.1 - 0.33 11.0 11.0 0.2 11.7 9.1 1.7 1 1 0 1 1 1 0 RING-type zinc-finger ANF_receptor PF01094.28 ORX56420.1 - 2.9e-29 102.3 0.0 1e-28 100.5 0.1 1.7 2 0 0 2 2 2 1 Receptor family ligand binding region 7tm_3 PF00003.22 ORX56420.1 - 9.8e-29 100.7 34.0 1.5e-28 100.1 34.0 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Peripla_BP_6 PF13458.6 ORX56420.1 - 2.8e-06 27.2 0.1 4.5e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Periplasmic binding protein PH_9 PF15410.6 ORX56420.1 - 0.0055 17.1 0.8 0.012 15.9 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain Cation_efflux PF01545.21 ORX56421.1 - 1.7e-50 171.6 6.3 2.5e-50 171.0 6.3 1.3 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ORX56421.1 - 1.5e-13 50.7 1.7 2.5e-13 49.9 1.7 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter MycE_N PF17843.1 ORX56421.1 - 0.094 13.2 0.0 0.26 11.8 0.0 1.8 1 1 0 1 1 1 0 MycE methyltransferase N-terminal DUF4473 PF14747.6 ORX56421.1 - 0.13 12.9 0.1 0.41 11.2 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) GDP_Man_Dehyd PF16363.5 ORX56422.1 - 4.1e-59 200.6 0.0 1.9e-58 198.4 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ORX56422.1 - 1.8e-47 161.8 0.0 2.5e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX56422.1 - 4.3e-11 42.4 0.0 9.5e-11 41.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ORX56422.1 - 8.8e-10 38.2 0.0 1.8e-05 24.1 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ORX56422.1 - 8.5e-09 35.0 0.1 3.2e-05 23.2 0.1 2.8 2 1 0 2 2 2 2 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX56422.1 - 1.6e-08 34.0 0.0 2.1e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 ORX56422.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase Ras PF00071.22 ORX56423.1 - 1.6e-67 226.1 0.1 2e-67 225.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX56423.1 - 6.4e-35 120.0 0.1 1.4e-34 118.9 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX56423.1 - 2.3e-15 56.5 0.0 3e-15 56.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX56423.1 - 2.2e-06 27.4 0.1 5.7e-06 26.0 0.1 1.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ORX56423.1 - 2.4e-05 23.8 0.0 3.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX56423.1 - 5.5e-05 22.6 0.1 6.5e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX56423.1 - 0.00025 21.0 0.2 0.28 11.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX56423.1 - 0.00025 21.1 0.1 0.00058 19.9 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX56423.1 - 0.0078 15.8 0.1 0.12 11.9 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_29 PF13555.6 ORX56423.1 - 0.047 13.5 0.1 0.13 12.0 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX56423.1 - 0.065 13.6 0.0 0.1 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX56423.1 - 0.11 12.9 0.0 5.3 7.5 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX56423.1 - 0.12 12.4 0.2 0.44 10.5 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Ceramidase_alk PF04734.13 ORX56424.1 - 2.4e-180 600.5 0.0 9.4e-162 539.2 0.0 2.0 2 0 0 2 2 2 2 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 ORX56424.1 - 6e-39 133.6 0.0 9.8e-39 132.9 0.0 1.4 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Glyco_transf_15 PF01793.16 ORX56425.1 - 6.9e-111 370.6 4.1 8.7e-111 370.3 4.1 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase zf-HYPF PF07503.12 ORX56425.1 - 0.04 13.7 1.5 0.13 12.0 1.5 1.9 1 0 0 1 1 1 0 HypF finger RhoGAP PF00620.27 ORX56426.1 - 4e-41 140.4 0.0 7e-41 139.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 ORX56426.1 - 2e-13 50.8 0.0 5.2e-13 49.4 0.0 1.7 1 0 0 1 1 1 1 PH domain PX PF00787.24 ORX56426.1 - 8.6e-08 32.2 0.0 3.7e-07 30.1 0.0 2.1 2 0 0 2 2 2 1 PX domain PH_11 PF15413.6 ORX56426.1 - 0.0063 16.9 1.9 0.015 15.7 0.1 2.6 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ORX56426.1 - 0.022 15.0 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain Cad PF03596.13 ORX56427.1 - 1.2e-18 67.7 2.5 1.2e-18 67.7 2.5 1.5 2 0 0 2 2 2 1 Cadmium resistance transporter Insulin_TMD PF17870.1 ORX56427.1 - 0.0056 16.7 3.5 0.13 12.4 0.1 2.8 2 0 0 2 2 2 1 Insulin receptor trans-membrane segment UPF0220 PF05255.11 ORX56427.1 - 0.044 13.3 0.4 0.081 12.5 0.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0220) DUF3671 PF12420.8 ORX56427.1 - 0.25 11.4 10.1 0.039 14.0 5.0 2.0 1 1 1 2 2 2 0 Protein of unknown function T4_Gp59_C PF08994.10 ORX56427.1 - 0.37 11.4 1.9 1.8 9.2 0.0 2.5 2 1 1 3 3 3 0 T4 gene Gp59 loader of gp41 DNA helicase C-term DUF3278 PF11683.8 ORX56427.1 - 0.97 9.5 5.5 4.9 7.2 5.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3278) DHHC PF01529.20 ORX56427.1 - 2.8 8.1 7.3 14 5.7 5.2 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase DPM3 PF08285.11 ORX56427.1 - 8.9 6.6 8.9 4.7 7.5 2.3 2.6 2 1 1 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) HTH_32 PF13565.6 ORX56428.1 - 7e-08 33.0 0.0 1.6e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 ORX56428.1 - 1.2e-05 25.3 0.0 4.2e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 ORX56428.1 - 0.00019 21.1 0.0 0.0004 20.1 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_29 PF13551.6 ORX56428.1 - 0.00022 21.2 0.0 0.00051 20.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix HTH_Tnp_1 PF01527.20 ORX56428.1 - 0.095 13.0 0.2 0.23 11.8 0.0 1.8 2 0 0 2 2 2 0 Transposase Terminase_5 PF06056.12 ORX56428.1 - 0.11 12.4 0.1 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) Glyco_transf_8 PF01501.20 ORX56432.1 - 3.5e-22 79.2 0.1 1.1e-19 71.0 0.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 ORX56432.1 - 0.0021 17.4 0.0 0.0024 17.3 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 ORX56432.1 - 0.048 13.6 0.0 0.072 13.1 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase PTH2 PF01981.16 ORX56433.1 - 5.3e-46 155.7 0.1 6.5e-46 155.4 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 CorA PF01544.18 ORX56434.1 - 9.8e-49 166.2 8.7 1.9e-29 102.9 2.0 2.3 1 1 1 2 2 2 2 CorA-like Mg2+ transporter protein DUF2383 PF09537.10 ORX56434.1 - 0.16 12.3 0.7 13 6.2 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF2383) GyrB_insert PF18053.1 ORX56434.1 - 0.76 9.6 4.7 0.44 10.4 1.2 2.3 3 0 0 3 3 3 0 DNA gyrase B subunit insert domain TMEM208_SND2 PF05620.11 ORX56435.1 - 8.3e-44 149.3 1.2 9.2e-44 149.2 1.2 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 CSTF2_hinge PF14327.6 ORX56436.1 - 7e-24 84.1 0.6 7e-24 84.1 0.6 2.1 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 ORX56436.1 - 1.2e-20 73.1 0.2 4.9e-20 71.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 ORX56436.1 - 4.4e-14 51.8 10.5 1.6e-13 50.0 10.5 2.1 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 ORX56436.1 - 0.0068 16.5 0.2 0.016 15.3 0.2 1.7 1 1 0 1 1 1 1 RNA recognition motif Arm PF00514.23 ORX56437.1 - 3.1e-08 33.4 13.4 0.0015 18.5 0.0 6.7 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX56437.1 - 0.0057 17.1 0.0 0.078 13.5 0.0 3.0 3 0 0 3 3 3 1 HEAT-like repeat SNF2_N PF00176.23 ORX56438.1 - 7e-67 225.6 0.0 1.4e-66 224.7 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX56438.1 - 2.5e-18 66.4 0.0 4.9e-18 65.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ORX56438.1 - 5e-06 25.9 0.0 2.6e-05 23.6 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 ORX56438.1 - 0.01 15.1 0.0 0.021 14.0 0.0 1.5 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 ORX56438.1 - 0.042 13.5 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 SWI2/SNF2 ATPase NDUFA12 PF05071.16 ORX56440.1 - 2.3e-09 38.0 8.6 6.9e-09 36.4 8.6 1.8 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TEX19 PF15553.6 ORX56440.1 - 0.015 15.2 1.9 0.023 14.7 1.9 1.2 1 0 0 1 1 1 0 Testis-expressed protein 19 SQHop_cyclase_N PF13249.6 ORX56442.1 - 9.5e-09 34.8 0.5 7e-08 31.9 0.2 2.0 1 1 1 2 2 2 1 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 ORX56442.1 - 0.06 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Prenyltransferase and squalene oxidase repeat PUF PF00806.19 ORX56445.1 - 1.7e-40 134.4 2.2 2.5e-05 23.7 0.0 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 ORX56445.1 - 0.00016 22.0 0.2 4.4 7.7 0.1 3.9 1 1 2 3 3 3 3 CPL (NUC119) domain ArAE_2_N PF10337.9 ORX56446.1 - 3.7e-27 95.5 12.2 5.9e-19 68.4 0.0 3.5 3 1 1 4 4 4 3 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 ORX56446.1 - 1.5e-16 60.6 17.6 1.5e-16 60.6 17.6 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like ArAE_2 PF10334.9 ORX56446.1 - 8.1e-13 48.7 0.5 2.4e-12 47.2 0.1 2.0 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ALMT PF11744.8 ORX56446.1 - 8.7e-12 44.6 9.7 5.2e-10 38.7 7.8 2.6 2 0 0 2 2 2 2 Aluminium activated malate transporter FUSC PF04632.12 ORX56446.1 - 1.7e-09 36.8 19.7 1.7e-09 36.8 19.7 3.8 2 1 2 4 4 4 2 Fusaric acid resistance protein family FUSC-like PF12805.7 ORX56446.1 - 0.00034 19.8 1.2 0.001 18.2 1.2 1.9 1 0 0 1 1 1 1 FUSC-like inner membrane protein yccS Vpu PF00558.19 ORX56446.1 - 0.18 11.6 1.6 8.8 6.2 0.6 2.7 2 0 0 2 2 2 0 Vpu protein ArAE_1 PF06081.11 ORX56446.1 - 0.63 10.2 21.0 0.012 15.8 8.0 3.3 3 0 0 3 3 3 0 Aromatic acid exporter family member 1 Nucleocap_ssRNA PF11128.8 ORX56447.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.0 1 0 0 1 1 1 0 Plant viral coat protein nucleocapsid SRP54 PF00448.22 ORX56448.1 - 1.6e-78 262.9 0.5 3.8e-78 261.6 0.5 1.7 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ORX56448.1 - 7.8e-34 116.3 2.2 7.8e-34 116.3 2.2 4.6 2 1 2 4 4 4 1 Signal peptide binding domain SRP54_N PF02881.19 ORX56448.1 - 6.7e-20 71.1 3.4 8e-20 70.8 1.6 2.1 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain cobW PF02492.19 ORX56448.1 - 3.5e-06 26.7 5.2 4.1e-06 26.5 0.3 3.2 3 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 ORX56448.1 - 3.2e-05 24.0 0.0 0.00033 20.7 0.0 2.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_33 PF13671.6 ORX56448.1 - 0.00012 22.3 0.1 0.00037 20.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX56448.1 - 0.00046 20.6 0.0 0.00095 19.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ORX56448.1 - 0.00094 19.0 0.9 0.0025 17.6 0.0 2.2 3 0 0 3 3 1 1 AAA domain Zeta_toxin PF06414.12 ORX56448.1 - 0.0015 17.9 0.0 0.003 16.8 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin SRPRB PF09439.10 ORX56448.1 - 0.0019 17.7 1.5 1 8.7 0.1 2.7 2 1 1 3 3 3 2 Signal recognition particle receptor beta subunit ResIII PF04851.15 ORX56448.1 - 0.0029 17.6 0.6 0.0083 16.1 0.6 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit CLP1_P PF16575.5 ORX56448.1 - 0.0037 17.1 0.1 1.3 8.8 0.0 2.4 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Thymidylate_kin PF02223.17 ORX56448.1 - 0.0078 15.9 0.1 0.075 12.7 0.1 2.5 3 0 0 3 3 3 1 Thymidylate kinase AAA_17 PF13207.6 ORX56448.1 - 0.01 16.2 0.2 0.01 16.2 0.2 2.8 3 1 0 3 3 2 0 AAA domain APS_kinase PF01583.20 ORX56448.1 - 0.012 15.5 0.1 0.033 14.1 0.1 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase Corazonin PF17308.2 ORX56448.1 - 0.015 15.6 0.3 8.1 6.8 0.0 2.8 3 0 0 3 3 2 0 Pro-corazonin 6PF2K PF01591.18 ORX56448.1 - 0.017 14.4 0.0 0.032 13.5 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 ORX56448.1 - 0.017 15.2 0.6 0.093 12.8 0.1 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase Paramyxo_P PF01806.17 ORX56448.1 - 0.021 14.3 0.1 8.7 5.7 0.2 2.5 1 1 1 2 2 2 0 Paramyxovirinae P phosphoprotein C-terminal region AAA_28 PF13521.6 ORX56448.1 - 0.038 14.2 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain VirE PF05272.11 ORX56448.1 - 0.041 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Virulence-associated protein E MobB PF03205.14 ORX56448.1 - 0.075 12.9 0.3 0.2 11.6 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.6 ORX56448.1 - 0.08 13.2 0.3 0.33 11.2 0.3 2.2 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ORX56448.1 - 0.081 12.7 2.9 0.11 12.2 0.1 2.7 4 0 0 4 4 3 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ORX56448.1 - 0.09 13.3 0.6 0.71 10.4 0.1 2.9 3 1 0 3 3 2 0 AAA domain AAA_19 PF13245.6 ORX56448.1 - 0.09 13.1 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Arf PF00025.21 ORX56448.1 - 0.092 12.2 0.0 0.3 10.5 0.0 1.8 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_31 PF13614.6 ORX56448.1 - 0.097 12.6 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain Ly49 PF08391.10 ORX56448.1 - 0.17 12.3 0.3 0.53 10.7 0.3 1.8 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region AAA PF00004.29 ORX56448.1 - 0.45 10.9 4.3 0.39 11.2 0.6 2.7 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) YlbD_coat PF14071.6 ORX56448.1 - 0.87 9.9 5.8 5.3 7.3 0.8 3.3 1 1 1 2 2 2 0 Putative coat protein ArsA_ATPase PF02374.15 ORX56448.1 - 4.4 6.4 7.9 6.4 5.9 0.1 3.2 2 2 1 3 3 3 0 Anion-transporting ATPase ADK PF00406.22 ORX56449.1 - 1.8e-61 206.7 0.0 2.8e-61 206.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX56449.1 - 2.5e-21 76.5 0.1 1e-20 74.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 ORX56449.1 - 7.8e-17 61.0 0.0 2.6e-16 59.3 0.0 1.9 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ORX56449.1 - 1.7e-05 25.4 0.0 5.6e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ORX56449.1 - 0.0002 21.5 0.0 0.0004 20.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain Aminotran_3 PF00202.21 ORX56449.1 - 0.026 13.2 0.0 0.046 12.4 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-III Cytidylate_kin PF02224.18 ORX56449.1 - 0.054 13.2 0.0 0.097 12.4 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase Tmemb_cc2 PF10267.9 ORX56449.1 - 0.19 10.8 0.7 3 6.9 0.0 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DEAD PF00270.29 ORX56450.1 - 3.5e-06 26.9 0.1 4.1e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ORX56450.1 - 0.025 14.6 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Exo_endo_phos PF03372.23 ORX56706.1 - 1.4e-06 28.0 0.0 2.2e-06 27.4 0.0 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX56706.1 - 2.3e-06 27.5 0.1 4.3e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF1414 PF07208.11 ORX56706.1 - 0.12 12.4 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1414) Exo_endo_phos PF03372.23 ORX56708.1 - 4.7e-10 39.4 0.0 1.6e-09 37.6 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX56708.1 - 3.4e-05 23.6 0.2 0.00018 21.3 0.2 2.1 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 ORX56710.1 - 1.2e-09 38.8 0.4 3.7e-09 37.2 0.4 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase FKBP_C PF00254.28 ORX56711.1 - 3.8e-22 78.4 0.0 4.3e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF2536 PF10750.9 ORX56711.1 - 0.12 12.3 0.0 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2536) zf-RVT PF13966.6 ORX56713.1 - 1e-08 35.7 0.1 2.1e-08 34.8 0.1 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase PaO PF08417.12 ORX56713.1 - 0.089 12.9 0.0 0.13 12.4 0.0 1.4 1 1 0 1 1 1 0 Pheophorbide a oxygenase Nucleoporin_N PF08801.11 ORX56714.1 - 2e-07 30.1 0.1 2.4e-07 29.9 0.1 1.1 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ORX56715.1 - 2.3e-08 33.2 3.4 3e-08 32.9 3.4 1.1 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal RRM_1 PF00076.22 ORX56716.1 - 2.7e-18 65.6 0.0 5.3e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX56716.1 - 0.003 17.2 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_8 PF11835.8 ORX56716.1 - 0.045 14.0 0.0 0.075 13.3 0.0 1.3 1 0 0 1 1 1 0 RRM-like domain HHV-1_VABD PF16852.5 ORX56716.1 - 0.065 13.2 1.0 0.1 12.6 0.1 1.8 2 0 0 2 2 2 0 Herpes viral adaptor-to-host cellular mRNA binding domain MMM1 PF10296.9 ORX56717.1 - 1.6e-07 30.7 0.0 2e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 CRAL_TRIO PF00650.20 ORX56718.1 - 3.8e-17 62.5 0.1 5.9e-17 61.8 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain Med19 PF10278.9 ORX56718.1 - 2.5 8.0 9.3 30 4.5 0.0 2.3 1 1 1 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Glyco_hydro_18 PF00704.28 ORX56719.1 - 2.1e-69 234.6 3.4 2.1e-69 234.6 3.4 1.4 2 0 0 2 2 2 1 Glycosyl hydrolases family 18 CBM_5_12 PF02839.14 ORX56719.1 - 0.016 15.7 4.3 0.016 15.7 4.3 3.9 4 0 0 4 4 4 0 Carbohydrate binding domain Mucin PF01456.17 ORX56719.1 - 0.22 11.5 29.1 0.61 10.1 29.1 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein CtnDOT_TraJ PF07863.11 ORX56719.1 - 7.9 7.2 7.4 31 5.3 7.2 2.2 1 1 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon E1-E2_ATPase PF00122.20 ORX56720.1 - 3.3e-43 147.3 5.0 3.3e-43 147.3 5.0 3.0 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 ORX56720.1 - 6.5e-19 69.1 0.2 1.5e-18 67.9 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX56720.1 - 1.3e-11 44.0 0.0 4.8e-11 42.2 0.0 2.0 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX56720.1 - 0.041 13.6 0.2 0.099 12.4 0.1 1.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase ABC_tran PF00005.27 ORX56721.1 - 9.8e-47 158.9 1.4 2.7e-22 79.8 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 ORX56721.1 - 3.2e-24 84.8 2.6 3.2e-24 84.8 2.6 2.4 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 ORX56721.1 - 1.9e-12 47.6 10.5 0.0033 17.3 0.3 5.1 3 2 1 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX56721.1 - 5.5e-12 45.6 0.9 0.0022 17.5 0.0 3.8 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX56721.1 - 3.8e-07 29.7 0.3 0.012 15.3 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_15 PF13175.6 ORX56721.1 - 4.2e-07 30.0 4.7 0.0051 16.6 0.0 4.1 3 1 1 4 4 4 2 AAA ATPase domain MMR_HSR1 PF01926.23 ORX56721.1 - 1.1e-06 28.8 0.0 0.052 13.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA PF00004.29 ORX56721.1 - 3.2e-06 27.6 0.2 0.051 14.0 0.0 4.0 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ORX56721.1 - 4.2e-06 27.1 0.3 0.045 14.0 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 ORX56721.1 - 7.9e-06 26.5 15.6 0.051 14.1 0.0 4.9 5 0 0 5 5 5 2 AAA domain RsgA_GTPase PF03193.16 ORX56721.1 - 8.3e-06 25.8 0.0 0.16 11.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 ORX56721.1 - 5.5e-05 23.4 5.6 0.32 11.2 0.1 4.8 2 2 1 3 3 3 2 AAA domain AAA_16 PF13191.6 ORX56721.1 - 7.9e-05 23.1 3.4 0.073 13.5 0.0 3.4 4 1 0 4 4 3 2 AAA ATPase domain AAA_14 PF13173.6 ORX56721.1 - 8e-05 22.7 0.0 0.39 10.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ORX56721.1 - 0.00012 22.6 1.8 1.2 9.7 0.0 3.9 5 0 0 5 5 3 2 AAA domain AAA_24 PF13479.6 ORX56721.1 - 0.0003 20.6 0.2 0.62 9.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_33 PF13671.6 ORX56721.1 - 0.00037 20.7 4.7 0.87 9.7 0.0 3.9 3 2 0 3 3 3 2 AAA domain NACHT PF05729.12 ORX56721.1 - 0.00049 20.1 1.0 0.24 11.3 0.0 2.8 3 0 0 3 3 2 1 NACHT domain AAA_30 PF13604.6 ORX56721.1 - 0.0011 18.7 0.1 0.31 10.8 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ORX56721.1 - 0.0025 17.4 0.1 0.83 9.2 0.0 2.8 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ORX56721.1 - 0.0034 16.6 0.0 0.9 8.7 0.0 3.0 3 0 0 3 3 3 1 NB-ARC domain AAA_27 PF13514.6 ORX56721.1 - 0.0034 17.0 1.7 0.68 9.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 ORX56721.1 - 0.004 17.5 0.0 4.1 7.9 0.0 2.6 2 0 0 2 2 2 1 RNA helicase Roc PF08477.13 ORX56721.1 - 0.014 15.6 0.0 7.4 6.8 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 ORX56721.1 - 0.018 14.7 1.8 2.8 7.5 0.1 3.1 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 ORX56721.1 - 0.02 14.8 0.0 12 5.8 0.0 3.0 3 0 0 3 3 3 0 NTPase IstB_IS21 PF01695.17 ORX56721.1 - 0.027 14.2 0.1 3.4 7.4 0.0 2.7 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 ORX56721.1 - 0.051 13.6 0.0 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 ORX56721.1 - 0.051 12.6 3.6 4.1 6.3 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP-synt_ab PF00006.25 ORX56721.1 - 0.058 13.0 0.0 0.4 10.3 0.0 2.2 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 ORX56721.1 - 0.07 12.6 0.1 4.2 6.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Dynamin_N PF00350.23 ORX56721.1 - 0.1 12.6 10.4 0.51 10.4 0.1 3.4 4 1 0 4 4 3 0 Dynamin family AAA_5 PF07728.14 ORX56721.1 - 0.11 12.5 1.5 11 6.0 0.1 3.4 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) Biotin_carb_N PF00289.22 ORX56721.1 - 0.15 12.7 0.4 1.3 9.6 0.0 2.4 2 0 0 2 2 2 0 Biotin carboxylase, N-terminal domain HNF-1B_C PF04812.13 ORX56721.1 - 0.16 11.7 0.2 0.25 11.1 0.2 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus SbcCD_C PF13558.6 ORX56721.1 - 0.21 11.9 1.8 1.4 9.2 0.2 3.0 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_17 PF13207.6 ORX56721.1 - 5.6 7.4 6.1 56 4.2 0.0 3.9 3 1 0 3 3 3 0 AAA domain OrfB_Zn_ribbon PF07282.11 ORX56722.1 - 0.019 14.9 0.1 0.063 13.2 0.1 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain RHD3 PF05879.12 ORX56723.1 - 1.1e-246 820.7 13.3 4.1e-213 709.7 9.9 2.0 1 1 1 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 ORX56723.1 - 5e-06 26.7 0.2 1.7e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 ORX56723.1 - 8.2e-06 25.9 1.2 1.9e-05 24.7 0.1 2.3 2 2 0 2 2 2 1 50S ribosome-binding GTPase GBP PF02263.19 ORX56723.1 - 1e-05 25.0 0.4 1e-05 25.0 0.4 2.2 2 1 1 3 3 3 1 Guanylate-binding protein, N-terminal domain AAA_28 PF13521.6 ORX56723.1 - 0.0031 17.8 0.0 0.0098 16.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain ELM2 PF01448.24 ORX56723.1 - 0.017 15.9 1.5 2.3 9.0 1.2 3.0 2 1 0 2 2 2 0 ELM2 domain Septin PF00735.18 ORX56723.1 - 0.038 13.3 0.7 0.14 11.4 0.1 2.2 2 0 0 2 2 2 0 Septin DUF1612 PF07756.12 ORX56723.1 - 0.039 14.2 0.2 0.11 12.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) FeoB_N PF02421.18 ORX56723.1 - 0.058 12.9 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX56723.1 - 0.18 11.7 3.3 0.61 10.0 0.2 2.8 3 0 0 3 3 3 0 RsgA GTPase DHHC PF01529.20 ORX56725.1 - 5.9e-35 120.3 13.2 5.9e-35 120.3 13.2 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_2 PF12796.7 ORX56725.1 - 2.9e-27 95.1 2.7 1.2e-12 48.2 0.2 3.5 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX56725.1 - 2.3e-23 79.7 3.0 0.00071 19.8 0.0 5.8 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 ORX56725.1 - 1.9e-22 79.3 6.2 2.4e-09 37.5 0.3 4.0 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX56725.1 - 2.3e-22 78.8 7.1 1.2e-09 38.2 0.0 4.9 2 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 ORX56725.1 - 1.1e-20 73.1 7.2 0.00031 21.1 0.1 5.7 5 0 0 5 5 5 5 Ankyrin repeat D123 PF07065.14 ORX56725.1 - 0.095 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 D123 ORC5_C PF14630.6 ORX56726.1 - 2.1e-66 224.4 0.1 2.6e-66 224.0 0.1 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 ORX56726.1 - 2.7e-11 44.2 0.0 1.4e-07 32.1 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain ATPase_2 PF01637.18 ORX56726.1 - 2.3e-05 24.4 0.0 4.5e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ORX56726.1 - 0.00029 21.1 0.0 0.00092 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ORX56726.1 - 0.044 13.0 0.0 0.064 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DNA_pol3_delta2 PF13177.6 ORX56726.1 - 0.092 12.5 0.0 0.28 10.9 0.0 1.7 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Metallophos PF00149.28 ORX56727.1 - 5.2e-39 134.9 0.4 7.5e-39 134.3 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX56727.1 - 0.0013 19.2 0.3 0.0026 18.2 0.3 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 ORX56727.1 - 0.034 14.3 0.0 0.052 13.7 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain TMEM117 PF15113.6 ORX56729.1 - 0.13 11.1 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 TMEM117 protein family Histone PF00125.24 ORX56730.1 - 0.00032 21.1 0.0 0.00037 20.9 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 HemX PF04375.14 ORX56730.1 - 0.079 12.2 0.0 0.084 12.1 0.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CHCH PF06747.13 ORX56731.1 - 1.1e-06 28.6 4.2 2.1e-06 27.7 4.2 1.5 1 0 0 1 1 1 1 CHCH domain CX9C PF16860.5 ORX56731.1 - 0.026 14.5 2.4 0.053 13.5 2.4 1.5 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RAB3GAP2_N PF14655.6 ORX56731.1 - 0.043 13.1 0.8 0.055 12.7 0.8 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus MTCP1 PF08991.10 ORX56731.1 - 0.061 13.6 4.8 0.099 12.9 4.8 1.4 1 0 0 1 1 1 0 Mature-T-Cell Proliferation I type DUF4179 PF13786.6 ORX56731.1 - 0.2 12.1 0.0 0.26 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) DUF2076 PF09849.9 ORX56731.1 - 0.81 9.7 32.8 7.6 6.5 32.0 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) adh_short PF00106.25 ORX56732.1 - 6.4e-19 68.2 0.1 3.6e-18 65.7 0.1 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX56732.1 - 6.2e-10 39.0 0.0 0.00025 20.7 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX56732.1 - 3.5e-06 27.1 0.0 7.4e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 ORX56732.1 - 0.0027 16.9 0.0 0.2 10.8 0.0 2.4 1 1 1 2 2 2 2 Male sterility protein DUF624 PF04854.14 ORX56732.1 - 0.0052 16.9 0.8 0.018 15.2 0.6 1.9 1 1 1 2 2 2 1 Protein of unknown function, DUF624 NAD_binding_10 PF13460.6 ORX56732.1 - 0.0056 16.6 0.0 0.032 14.1 0.0 2.1 1 1 0 1 1 1 1 NAD(P)H-binding zinc_ribbon_16 PF17034.5 ORX56733.1 - 1.5e-22 80.1 18.3 1.7e-22 80.0 15.3 2.5 2 1 1 3 3 3 1 Zinc-ribbon like family Nup84_Nup100 PF04121.13 ORX56733.1 - 0.00077 17.7 0.1 0.001 17.3 0.1 1.1 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Zn_ribbon_17 PF17120.5 ORX56733.1 - 0.012 15.2 10.2 0.012 15.2 10.2 2.7 3 0 0 3 3 3 0 Zinc-ribbon, C4HC2 type DUF5406 PF17400.2 ORX56733.1 - 0.1 13.0 0.2 0.28 11.6 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5406) MAPEG PF01124.18 ORX56734.1 - 0.026 14.4 9.3 0.044 13.7 9.3 1.5 1 1 0 1 1 1 0 MAPEG family Nop25 PF09805.9 ORX56735.1 - 1.5e-23 83.8 23.9 1.9e-23 83.4 23.9 1.1 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) GvpG PF05120.12 ORX56735.1 - 0.11 12.5 5.7 0.047 13.7 2.9 1.9 1 1 0 1 1 1 0 Gas vesicle protein G EMC3_TMCO1 PF01956.16 ORX56735.1 - 0.92 9.2 4.7 0.52 10.0 2.9 1.5 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Syja_N PF02383.18 ORX56736.1 - 2e-87 293.5 0.0 2.5e-87 293.2 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain NT5C PF06941.12 ORX56737.1 - 1.9e-12 47.4 0.3 9.9e-12 45.1 0.1 1.9 2 0 0 2 2 2 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_2 PF13419.6 ORX56737.1 - 2.8e-05 24.3 0.1 0.00011 22.3 0.1 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX56737.1 - 0.0013 19.1 0.1 0.0042 17.5 0.0 1.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX56737.1 - 0.051 13.9 0.1 0.41 10.9 0.0 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase NES_C_h PF18208.1 ORX56737.1 - 0.14 12.5 0.1 0.35 11.2 0.0 1.8 2 0 0 2 2 2 0 Nicking enzyme C-terminal middle helical domain Pkinase PF00069.25 ORX56738.1 - 1.1e-72 244.6 0.0 2e-72 243.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56738.1 - 1.3e-39 136.1 0.0 2.4e-39 135.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX56738.1 - 5.6e-10 39.0 0.3 2.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like KA1 PF02149.19 ORX56738.1 - 1.1e-09 37.9 0.1 1.9e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 ORX56738.1 - 0.073 12.0 0.4 0.19 10.6 0.4 1.7 1 0 0 1 1 1 0 Haspin like kinase domain NADH_dehy_S2_C PF06444.11 ORX56738.1 - 3.2 8.4 9.2 16 6.1 9.2 2.3 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus Y_phosphatase2 PF03162.13 ORX56739.1 - 7e-38 129.8 0.0 8.4e-38 129.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX56739.1 - 0.0063 16.5 0.0 0.0082 16.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX56739.1 - 0.037 13.6 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase PT-VENN PF04829.13 ORX56740.1 - 0.02 15.0 5.5 0.02 15.0 5.5 2.2 2 1 1 3 3 3 0 Pre-toxin domain with VENN motif Gly-zipper_YMGG PF13441.6 ORX56740.1 - 0.056 13.2 14.4 0.12 12.2 2.6 2.2 1 1 1 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 ORX56740.1 - 0.14 12.2 16.3 0.66 10.0 5.9 2.3 1 1 1 2 2 2 0 Glycine zipper Gly-zipper_OmpA PF13436.6 ORX56740.1 - 0.28 11.0 12.3 31 4.4 12.3 2.3 1 1 0 1 1 1 0 Glycine-zipper domain Rick_17kDa_Anti PF05433.15 ORX56740.1 - 0.29 11.0 16.9 1.7 8.6 12.9 2.3 2 0 0 2 2 2 0 Glycine zipper 2TM domain PsbT PF01405.17 ORX56741.1 - 0.12 12.2 0.8 0.28 11.0 0.8 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre T protein HAMP PF00672.25 ORX56743.1 - 0.013 15.9 0.1 4.3 7.8 0.0 2.2 1 1 1 2 2 2 0 HAMP domain DUF948 PF06103.11 ORX56743.1 - 0.14 12.4 0.0 0.21 11.9 0.0 1.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1746 PF08508.10 ORX56744.1 - 3.1e-15 56.5 14.7 8e-15 55.2 14.7 1.7 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) CH PF00307.31 ORX56745.1 - 2.4e-84 278.7 0.3 3.9e-22 78.5 0.0 4.3 4 0 0 4 4 4 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ORX56745.1 - 7.5e-13 48.1 0.1 0.0011 18.7 0.0 4.4 4 0 0 4 4 4 3 CAMSAP CH domain EF-hand_7 PF13499.6 ORX56745.1 - 1.3e-07 32.0 0.1 3.6e-07 30.5 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ORX56745.1 - 2.3e-06 26.8 0.7 0.00075 18.9 0.1 3.6 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ORX56745.1 - 5.2e-05 22.8 0.3 0.0004 20.1 0.1 2.6 2 1 1 3 3 3 1 EF-hand domain CH_2 PF06294.11 ORX56745.1 - 0.00067 19.7 0.3 1.1 9.4 0.0 3.7 5 1 0 5 5 5 2 CH-like domain in sperm protein RNB PF00773.19 ORX56745.1 - 0.0015 17.9 0.5 0.0028 17.0 0.2 1.5 2 0 0 2 2 2 1 RNB domain EF-hand_5 PF13202.6 ORX56745.1 - 0.0059 16.1 0.6 0.06 12.9 0.2 2.8 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ORX56745.1 - 0.046 13.6 0.4 1.5 8.7 0.2 2.7 1 1 1 2 2 2 0 EF-hand domain pair EF-hand_10 PF14788.6 ORX56745.1 - 0.1 12.5 0.2 0.53 10.2 0.1 2.3 2 0 0 2 2 2 0 EF hand HMG_box PF00505.19 ORX56749.1 - 1.6e-21 76.4 11.0 1e-10 41.9 1.9 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX56749.1 - 1.5e-16 60.7 9.0 3.1e-08 34.1 0.4 2.2 2 0 0 2 2 2 2 HMG-box domain DUF4303 PF14136.6 ORX56749.1 - 0.058 13.1 1.6 0.88 9.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) PKK PF12474.8 ORX56749.1 - 0.23 11.6 15.1 0.63 10.2 15.1 1.7 1 1 0 1 1 1 0 Polo kinase kinase DUF4790 PF16037.5 ORX56749.1 - 1.3 9.5 8.1 5.8 7.5 2.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4790) Syntaxin_2 PF14523.6 ORX56749.1 - 2.4 8.6 7.4 1.3 9.5 1.3 2.2 2 0 0 2 2 2 0 Syntaxin-like protein PGK PF00162.19 ORX56750.1 - 1e-150 501.9 0.3 1.1e-150 501.8 0.3 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase Copper-fist PF00649.18 ORX56751.1 - 1.7e-13 49.8 1.9 1.7e-13 49.8 1.9 2.6 2 1 0 2 2 2 1 Copper fist DNA binding domain adh_short PF00106.25 ORX56752.1 - 3.3e-42 144.2 0.5 3.9e-42 143.9 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX56752.1 - 5.7e-32 111.2 0.0 6.5e-32 111.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX56752.1 - 1e-13 51.6 0.1 1.3e-13 51.2 0.1 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX56752.1 - 1.9e-05 24.0 0.0 2.4e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_10 PF13460.6 ORX56752.1 - 0.003 17.5 0.3 0.0046 16.9 0.3 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Phage_sheath_1 PF04984.14 ORX56752.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Phage tail sheath protein subtilisin-like domain Mito_carr PF00153.27 ORX56753.1 - 3.6e-70 231.9 2.2 2.1e-22 78.8 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX56753.1 - 0.001 18.3 0.3 0.11 11.7 0.0 3.2 4 0 0 4 4 4 1 Gammaproteobacterial serine protease Pkinase PF00069.25 ORX56754.1 - 3.5e-64 216.7 0.0 1e-63 215.2 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56754.1 - 1.8e-34 119.2 0.0 3.1e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ORX56754.1 - 4.4e-20 71.3 24.0 2.9e-11 43.1 7.9 2.4 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 ORX56754.1 - 9.8e-16 57.6 12.7 6.5e-09 35.8 3.7 2.5 2 0 0 2 2 2 2 Hr1 repeat Pkinase_C PF00433.24 ORX56754.1 - 1.3e-10 41.8 0.2 1.3e-10 41.8 0.2 2.5 2 0 0 2 2 1 1 Protein kinase C terminal domain FTA2 PF13095.6 ORX56754.1 - 0.015 14.9 0.0 0.68 9.5 0.0 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX56754.1 - 0.027 13.4 0.0 0.046 12.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 ORX56754.1 - 0.089 12.1 0.0 0.19 11.0 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Uds1 PF15456.6 ORX56754.1 - 0.15 12.2 8.2 3.3 7.9 1.0 2.8 2 0 0 2 2 2 0 Up-regulated During Septation Golgin_A5 PF09787.9 ORX56754.1 - 0.22 10.9 6.0 3.6 7.0 0.9 2.3 2 0 0 2 2 2 0 Golgin subfamily A member 5 C1_2 PF03107.16 ORX56754.1 - 0.23 11.8 21.2 0.54 10.6 7.9 2.6 2 0 0 2 2 2 0 C1 domain TFIIIC_sub6 PF10419.9 ORX56755.1 - 2.1e-08 33.9 0.0 2.8e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain Vps4_C PF09336.10 ORX56755.1 - 0.022 14.7 0.1 0.1 12.6 0.0 1.9 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Cu_amine_oxidN3 PF02728.16 ORX56755.1 - 0.045 14.2 0.0 0.067 13.6 0.0 1.4 1 1 0 1 1 1 0 Copper amine oxidase, N3 domain G-alpha PF00503.20 ORX56756.1 - 6e-110 367.7 8.4 9.1e-110 367.1 8.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX56756.1 - 4.5e-14 52.3 1.8 1.8e-08 34.0 0.1 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ORX56756.1 - 0.0017 18.6 0.0 0.62 10.3 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX56756.1 - 0.0046 16.3 2.7 1.1 8.6 0.1 2.3 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region UBZ_FAAP20 PF15750.5 ORX56756.1 - 0.061 13.3 0.3 0.17 11.9 0.3 1.7 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger AAA_29 PF13555.6 ORX56756.1 - 0.077 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ORX56756.1 - 0.086 12.2 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family DAP3 PF10236.9 ORX56756.1 - 0.093 11.9 1.8 0.12 11.5 0.2 2.0 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 Zeta_toxin PF06414.12 ORX56756.1 - 0.15 11.3 0.0 0.35 10.1 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin Abhydrolase_3 PF07859.13 ORX56757.1 - 7.9e-30 104.3 0.0 1.4e-29 103.5 0.0 1.4 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX56757.1 - 6.3e-14 51.6 0.0 8.9e-14 51.1 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Peptidase_S9 PF00326.21 ORX56757.1 - 9.3e-05 22.0 0.0 0.00083 18.9 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family MukF_C PF17193.4 ORX56757.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.5 1 0 0 1 1 1 0 MukF C-terminal domain ParA PF10609.9 ORX56758.1 - 2.8e-98 328.3 0.5 3.2e-98 328.1 0.5 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ORX56758.1 - 4e-13 49.5 0.0 7.8e-13 48.6 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ORX56758.1 - 6.7e-10 39.2 1.7 1.4e-07 31.6 0.4 2.2 2 0 0 2 2 2 2 AAA domain Fer4_NifH PF00142.18 ORX56758.1 - 2.8e-08 33.5 0.4 6.8e-07 29.0 0.4 2.5 1 1 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 ORX56758.1 - 2.5e-06 27.0 0.3 3.6e-06 26.5 0.3 1.4 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 ORX56758.1 - 0.00029 20.1 0.8 0.0007 18.9 0.8 1.5 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_25 PF13481.6 ORX56758.1 - 0.0015 18.2 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain VirC1 PF07015.11 ORX56758.1 - 0.016 14.6 0.1 0.027 13.8 0.1 1.3 1 0 0 1 1 1 0 VirC1 protein SRP54 PF00448.22 ORX56758.1 - 0.06 13.0 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PhnA_Zn_Ribbon PF08274.12 ORX56758.1 - 0.069 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon CBP_BcsQ PF06564.12 ORX56758.1 - 0.09 12.2 0.2 1.3 8.4 0.0 2.1 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ Cyt-b5 PF00173.28 ORX56759.1 - 1.4e-19 70.0 0.1 1.4e-19 70.0 0.1 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Hid1 PF12722.7 ORX56760.1 - 4.7e-173 577.4 17.6 2e-168 562.1 10.0 2.1 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ORX56760.1 - 1.2e-95 321.3 7.2 1.4e-95 321.1 7.2 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Lipase_3 PF01764.25 ORX56761.1 - 2.6e-22 79.2 0.0 4.4e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_6 PF12697.7 ORX56761.1 - 0.0016 19.1 0.0 0.0031 18.2 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 ORX56761.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 Thioesterase domain Hydrolase_4 PF12146.8 ORX56761.1 - 0.019 14.2 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DUF2974 PF11187.8 ORX56761.1 - 0.22 11.1 0.0 0.63 9.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Beta_elim_lyase PF01212.21 ORX56762.1 - 9.6e-65 218.7 0.1 1.2e-64 218.5 0.1 1.0 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ORX56762.1 - 1.4e-07 31.0 0.0 2.1e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX56762.1 - 0.0003 19.5 0.1 0.00041 19.0 0.1 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX56762.1 - 0.00038 19.9 0.2 0.0013 18.2 0.2 1.9 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ORX56762.1 - 0.0033 16.4 0.0 0.0041 16.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V UQ_con PF00179.26 ORX56765.1 - 3.5e-45 153.1 0.0 3.9e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UFC1 PF08694.11 ORX56765.1 - 0.03 14.0 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 UEV PF05743.13 ORX56765.1 - 0.031 14.1 0.4 0.045 13.6 0.4 1.4 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 ORX56765.1 - 0.039 14.3 0.0 0.043 14.1 0.0 1.4 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 ORX56765.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 Prokaryotic E2 family B RRM_1 PF00076.22 ORX56766.1 - 7.8e-20 70.5 0.0 1e-19 70.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX56766.1 - 3.3e-05 23.5 0.0 3.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX56766.1 - 0.011 15.9 0.0 0.021 14.9 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif SH3_9 PF14604.6 ORX56767.1 - 8.1e-10 38.4 0.0 1.5e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX56767.1 - 1.3e-06 27.9 0.2 3.4e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ORX56767.1 - 0.0022 17.7 0.0 0.0041 16.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain Podoplanin PF05808.11 ORX56767.1 - 0.015 15.4 0.2 0.051 13.7 0.0 1.9 2 0 0 2 2 2 0 Podoplanin Romo1 PF10247.9 ORX56767.1 - 0.064 13.6 0.3 0.14 12.5 0.3 1.5 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 Adeno_E3_CR2 PF02439.15 ORX56767.1 - 0.15 11.8 3.6 0.31 10.8 3.6 1.5 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NOT2_3_5 PF04153.18 ORX56768.1 - 1.4e-27 96.4 0.6 1.9e-27 95.9 0.6 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family EF-hand_1 PF00036.32 ORX56769.1 - 2.1e-28 95.7 1.5 9.5e-08 31.1 0.0 4.9 5 1 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 ORX56769.1 - 4.3e-24 82.9 2.9 5.8e-06 25.6 0.0 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ORX56769.1 - 7.2e-24 81.6 2.3 6.1e-08 32.0 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ORX56769.1 - 1.1e-23 83.5 1.1 6.6e-09 36.1 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ORX56769.1 - 9e-17 60.7 8.6 1.6e-08 34.2 0.1 5.0 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_9 PF14658.6 ORX56769.1 - 0.00018 21.8 0.2 0.54 10.6 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain Caleosin PF05042.13 ORX56769.1 - 0.016 15.1 0.5 0.27 11.1 0.0 2.8 2 2 1 4 4 4 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 ORX56769.1 - 0.13 12.6 0.5 2.2 8.6 0.1 2.9 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Oxysterol_BP PF01237.18 ORX56770.1 - 3.4e-113 378.3 8.3 3.4e-113 378.3 8.3 2.3 3 1 0 3 3 3 1 Oxysterol-binding protein PH_8 PF15409.6 ORX56770.1 - 7.6e-21 74.2 1.5 1.3e-20 73.5 0.3 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ORX56770.1 - 8e-09 36.0 7.1 3.1e-08 34.1 0.2 3.1 3 0 0 3 3 3 1 PH domain GOLD_2 PF13897.6 ORX56770.1 - 0.0037 17.7 7.3 0.021 15.3 0.0 2.9 3 0 0 3 3 3 1 Golgi-dynamics membrane-trafficking PH_11 PF15413.6 ORX56770.1 - 0.065 13.7 0.4 0.065 13.7 0.4 4.5 4 1 1 5 5 5 0 Pleckstrin homology domain EMP24_GP25L PF01105.24 ORX56770.1 - 0.075 13.0 0.0 0.28 11.1 0.0 2.0 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD PH_13 PF16652.5 ORX56770.1 - 0.13 12.1 1.9 0.15 11.8 0.4 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain WD40 PF00400.32 ORX56771.1 - 3.3e-10 40.4 17.2 0.16 12.9 0.0 9.2 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX56771.1 - 2.2e-06 27.9 0.0 0.38 11.1 0.0 5.3 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Fes1 PF08609.10 ORX56772.1 - 2.4e-23 82.8 2.5 2.4e-23 82.8 2.5 2.5 2 1 0 2 2 2 1 Nucleotide exchange factor Fes1 HEAT PF02985.22 ORX56772.1 - 4.9e-07 29.5 0.1 0.091 13.1 0.0 4.5 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ORX56772.1 - 1.4e-06 28.6 0.3 0.046 14.1 0.0 3.5 2 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 ORX56772.1 - 0.00013 22.4 0.1 0.012 16.1 0.0 3.0 2 1 1 3 3 3 2 HEAT-like repeat Arm PF00514.23 ORX56772.1 - 0.00016 21.6 0.2 2 8.6 0.0 3.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 ORX56772.1 - 0.00026 20.7 1.4 0.00045 19.9 1.1 1.5 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II DUF3361 PF11841.8 ORX56772.1 - 0.00035 20.6 0.8 0.1 12.5 0.6 3.0 2 1 1 3 3 3 1 Domain of unknown function (DUF3361) Clathrin PF00637.20 ORX56772.1 - 0.015 15.2 0.1 0.68 9.8 0.0 2.7 2 1 1 3 3 3 0 Region in Clathrin and VPS RIX1 PF08167.12 ORX56772.1 - 0.041 13.6 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis RPT PF13446.6 ORX56772.1 - 0.21 11.5 1.8 1.3 9.0 0.1 2.8 3 0 0 3 3 3 0 A repeated domain in UCH-protein Telomere_reg-2 PF10193.9 ORX56772.1 - 0.3 11.5 2.0 14 6.2 0.2 3.1 2 1 1 3 3 3 0 Telomere length regulation protein DWNN PF08783.11 ORX56773.1 - 0.019 15.2 1.7 0.55 10.6 1.4 2.1 1 1 1 2 2 2 0 DWNN domain DUF1002 PF06207.11 ORX56773.1 - 0.031 13.8 0.3 0.034 13.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) FERM_f0 PF16511.5 ORX56773.1 - 0.04 14.2 0.2 0.08 13.3 0.2 1.5 1 1 0 1 1 1 0 N-terminal or F0 domain of Talin-head FERM DUF4809 PF16067.5 ORX56773.1 - 0.13 12.5 0.7 0.17 12.1 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4809) HHH_4 PF14490.6 ORX56773.1 - 0.13 12.2 0.0 2.8 8.0 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain CP2 PF04516.15 ORX56774.1 - 7.1e-44 149.8 0.4 8.9e-44 149.5 0.4 1.0 1 0 0 1 1 1 1 CP2 transcription factor Sec-ASP3 PF15432.6 ORX56774.1 - 0.048 13.8 0.0 0.087 13.0 0.0 1.4 1 0 0 1 1 1 0 Accessory Sec secretory system ASP3 MMR_HSR1 PF01926.23 ORX56775.1 - 4.6e-09 36.3 0.0 1.1e-08 35.1 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX56775.1 - 0.001 19.0 0.0 0.0038 17.1 0.0 1.9 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 ORX56775.1 - 0.0028 17.2 0.0 0.18 11.3 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ORX56775.1 - 0.06 12.8 0.1 0.13 11.7 0.0 1.5 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.18 ORX56775.1 - 0.11 12.1 0.2 8.2 5.9 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B FAD_binding_3 PF01494.19 ORX56776.1 - 2.3e-22 79.7 0.1 8.5e-22 77.9 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 ORX56776.1 - 2.6e-08 33.9 0.0 0.00035 20.3 0.0 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX56776.1 - 6.5e-08 32.2 0.0 0.0021 17.4 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX56776.1 - 4.7e-07 29.2 0.0 8.2e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 ORX56776.1 - 8.7e-06 25.8 1.1 0.094 12.7 0.0 3.4 3 0 0 3 3 3 2 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ORX56776.1 - 9.7e-05 22.5 0.0 0.00031 20.9 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 ORX56776.1 - 0.00021 20.3 0.0 0.42 9.4 0.0 2.2 2 0 0 2 2 2 2 Tryptophan halogenase Pyr_redox PF00070.27 ORX56776.1 - 0.00041 20.8 0.1 0.12 13.0 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ORX56776.1 - 0.0074 15.4 0.0 2 7.4 0.0 2.2 2 0 0 2 2 2 2 Squalene epoxidase Pyr_redox_3 PF13738.6 ORX56776.1 - 0.012 14.8 0.0 1.5 8.0 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX56776.1 - 0.027 13.7 0.1 0.16 11.2 0.0 2.0 2 0 0 2 2 2 0 Thi4 family Mqo PF06039.15 ORX56776.1 - 0.062 11.8 0.0 0.11 11.0 0.0 1.4 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) Gar1 PF04410.14 ORX56779.1 - 6.6e-42 142.9 1.0 9.3e-42 142.4 1.0 1.2 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region PBP1_TM PF14812.6 ORX56779.1 - 0.036 14.4 4.7 0.071 13.5 4.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1918 PF08940.11 ORX56779.1 - 0.1 12.2 0.1 0.25 11.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) DUF1690 PF07956.11 ORX56780.1 - 2.5e-28 99.2 8.4 3e-28 99.0 8.4 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) Rootletin PF15035.6 ORX56780.1 - 0.00041 20.4 7.3 0.00081 19.5 7.3 1.4 1 1 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Abi_2 PF07751.11 ORX56780.1 - 0.012 15.9 1.3 0.015 15.6 1.3 1.1 1 0 0 1 1 1 0 Abi-like protein PP2C_C PF07830.13 ORX56780.1 - 0.63 10.5 3.1 2.5 8.6 2.7 2.0 1 1 1 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Cation_ATPase_N PF00690.26 ORX56781.1 - 3.1e-13 49.2 0.0 5.3e-13 48.5 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus E1-E2_ATPase PF00122.20 ORX56781.1 - 8.1e-06 25.5 0.0 3.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Q_salvage PF10343.9 ORX56782.1 - 3.2e-118 394.4 0.0 3.8e-118 394.2 0.0 1.0 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family ORC3_N PF07034.11 ORX56783.1 - 6.2e-63 212.9 2.5 6.2e-63 212.9 2.5 2.5 2 2 0 2 2 2 1 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 ORX56783.1 - 1.1e-28 100.1 1.3 2.2e-13 50.5 0.1 2.9 1 1 1 2 2 2 2 Origin recognition complex winged helix C-terminal DUF2326 PF10088.9 ORX56783.1 - 0.0019 18.0 0.9 0.004 16.9 0.1 1.9 2 0 0 2 2 2 1 Uncharacterised protein conserved in bacteria (DUF2326) zf-MYND PF01753.18 ORX56784.1 - 1.8e-08 34.3 12.7 3.6e-08 33.4 12.7 1.5 1 0 0 1 1 1 1 MYND finger Sel1 PF08238.12 ORX56784.1 - 5.3e-08 33.3 9.2 0.025 15.3 0.5 6.8 8 0 0 8 8 8 3 Sel1 repeat IDEAL PF08858.10 ORX56784.1 - 0.021 14.6 0.6 12 5.8 0.0 2.7 2 0 0 2 2 2 0 IDEAL domain GATA PF00320.27 ORX56786.1 - 4.6e-16 58.1 6.3 8e-16 57.4 6.3 1.4 1 0 0 1 1 1 1 GATA zinc finger TDP43_N PF18694.1 ORX56786.1 - 0.0058 16.4 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 Transactive response DNA-binding protein N-terminal domain Haem_bd PF14376.6 ORX56786.1 - 0.036 14.0 0.1 0.08 12.9 0.1 1.5 1 0 0 1 1 1 0 Haem-binding domain Ribosomal_L32p PF01783.23 ORX56786.1 - 0.15 12.4 5.0 4.5 7.6 5.0 2.3 1 1 0 1 1 1 0 Ribosomal L32p protein family TF_Zn_Ribbon PF08271.12 ORX56786.1 - 0.19 11.3 2.3 1.6 8.3 0.3 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding AAA_lid_2 PF17863.1 ORX56787.1 - 2.7e-05 23.9 0.1 4.9e-05 23.1 0.1 1.4 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 ORX56787.1 - 0.0023 17.8 0.0 0.0053 16.6 0.0 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MBOAT PF03062.19 ORX56788.1 - 5.3e-36 124.7 4.7 8.9e-36 123.9 4.7 1.3 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family TMEM40 PF15817.5 ORX56788.1 - 0.2 11.4 1.4 14 5.5 0.2 2.7 2 0 0 2 2 2 0 Transmembrane protein 40 family RTC4 PF14474.6 ORX56788.1 - 0.22 11.7 0.1 0.55 10.4 0.0 1.6 2 0 0 2 2 2 0 RTC4-like domain E1-E2_ATPase PF00122.20 ORX56789.1 - 3e-41 140.9 1.8 9.9e-41 139.2 0.7 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX56789.1 - 3.5e-41 140.9 4.7 3.5e-41 140.9 4.7 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX56789.1 - 4.7e-24 85.8 0.1 3.1e-11 44.0 0.0 3.6 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX56789.1 - 5.7e-17 61.6 0.0 1.6e-16 60.2 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX56789.1 - 1.1e-14 53.8 0.0 2.4e-14 52.8 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX56789.1 - 8.8e-06 25.6 1.9 6.1e-05 22.9 0.3 2.8 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX56789.1 - 0.0052 17.2 0.0 1.5 9.2 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Acyl-CoA_dh_N PF02771.16 ORX56790.1 - 1.8e-18 67.3 0.0 2.5e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ORX56790.1 - 8.3e-16 58.0 0.0 1.5e-15 57.1 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain HpaB_N PF11794.8 ORX56790.1 - 0.0015 18.3 0.1 0.0021 17.8 0.1 1.1 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Epimerase PF01370.21 ORX56791.1 - 1.2e-17 64.2 0.9 4.3e-17 62.4 0.9 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX56791.1 - 1.2e-11 44.6 0.7 2.4e-11 43.6 0.7 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ORX56791.1 - 2e-08 33.6 2.2 1.4e-07 30.8 2.2 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ORX56791.1 - 2e-08 33.7 1.0 3.1e-07 29.8 1.0 2.0 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ORX56791.1 - 3.5e-06 26.8 1.5 0.0003 20.4 1.7 2.2 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 ORX56791.1 - 2e-05 24.6 0.9 4.6e-05 23.4 0.9 1.6 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX56791.1 - 2.6e-05 23.5 2.9 3.9e-05 22.9 2.9 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ORX56791.1 - 0.00026 20.5 4.3 0.00053 19.5 3.4 2.0 2 1 0 2 2 2 1 short chain dehydrogenase NAD_binding_10 PF13460.6 ORX56791.1 - 0.00034 20.5 0.7 0.00067 19.6 0.7 1.6 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 ORX56791.1 - 0.019 14.1 0.1 0.037 13.1 0.0 1.5 2 0 0 2 2 2 0 RmlD substrate binding domain adh_short_C2 PF13561.6 ORX56791.1 - 0.16 11.5 1.9 0.53 9.8 1.9 1.8 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase RRM_1 PF00076.22 ORX56792.1 - 2e-16 59.6 0.2 4.4e-16 58.5 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX56792.1 - 0.00028 20.8 0.1 0.00058 19.8 0.1 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 ORX56792.1 - 0.00099 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BRAP2 PF07576.12 ORX56792.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 BRCA1-associated protein 2 Acetyltransf_10 PF13673.7 ORX56793.1 - 1.2e-08 34.9 0.0 1.4e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX56793.1 - 2.8e-07 30.8 0.1 3.4e-07 30.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX56793.1 - 3.2e-06 27.5 0.1 3.9e-06 27.2 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX56793.1 - 0.00017 21.7 0.0 0.00024 21.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ORX56793.1 - 0.0021 18.0 0.0 0.0026 17.7 0.0 1.1 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ORX56793.1 - 0.0054 16.8 0.1 0.0066 16.5 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF4609 PF15382.6 ORX56793.1 - 0.048 13.6 0.0 0.077 12.9 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4609) Acetyltransf_15 PF17013.5 ORX56793.1 - 0.15 11.5 0.1 0.21 11.0 0.1 1.3 1 1 0 1 1 1 0 Putative acetyl-transferase M20_dimer PF07687.14 ORX56794.1 - 2.1e-11 43.7 0.0 6.7e-11 42.1 0.0 1.8 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX56794.1 - 3.2e-07 30.3 1.6 7.8e-07 29.0 1.6 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Hepsin-SRCR PF09272.10 ORX56794.1 - 0.081 13.4 0.1 0.52 10.9 0.0 2.1 2 0 0 2 2 2 0 Hepsin, SRCR domain PPR_2 PF13041.6 ORX56795.1 - 5.5e-09 36.1 0.0 0.81 9.9 0.0 6.4 7 0 0 7 7 7 3 PPR repeat family PPR PF01535.20 ORX56795.1 - 2.9e-07 30.3 0.0 0.079 13.2 0.0 7.1 8 0 0 8 8 8 1 PPR repeat PPR_3 PF13812.6 ORX56795.1 - 8e-07 29.0 0.7 0.00017 21.6 0.0 3.7 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX56795.1 - 0.0023 17.3 3.7 0.067 12.6 1.2 2.9 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX56795.1 - 0.0028 17.3 0.1 6.6 6.5 0.0 4.1 4 0 0 4 4 4 1 PPR repeat ECSIT PF06239.11 ORX56795.1 - 0.13 11.4 0.5 2.3 7.3 0.0 2.5 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_14 PF13428.6 ORX56795.1 - 0.19 12.7 7.2 34 5.6 0.3 5.7 5 1 1 6 6 6 0 Tetratricopeptide repeat Mito_carr PF00153.27 ORX56796.1 - 5.7e-57 189.6 5.2 2.1e-19 69.3 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ORX56796.1 - 2e-05 24.9 1.7 2e-05 24.9 1.7 2.4 2 1 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family NQR2_RnfD_RnfE PF03116.15 ORX56796.1 - 0.05 13.0 1.7 0.062 12.7 1.7 1.2 1 0 0 1 1 1 0 NQR2, RnfD, RnfE family DUF1751 PF08551.10 ORX56798.1 - 2.9e-26 91.9 4.4 2.9e-26 91.9 4.4 1.8 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 ORX56798.1 - 2.8e-07 30.7 13.9 5.6e-07 29.7 13.9 1.4 1 0 0 1 1 1 1 Rhomboid family Cyclin PF08613.11 ORX56799.1 - 3.5e-11 43.7 0.1 5.5e-11 43.1 0.1 1.3 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX56799.1 - 3.2e-07 30.1 0.2 1.5e-06 28.0 0.0 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain TPR_MLP1_2 PF07926.12 ORX56800.1 - 0.027 14.6 8.7 0.027 14.6 8.7 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ORX56800.1 - 0.088 12.9 21.3 0.92 9.6 9.5 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding HAP1_N PF04849.13 ORX56800.1 - 0.2 10.9 20.2 0.32 10.1 8.3 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region ZapB PF06005.12 ORX56800.1 - 0.61 10.6 25.5 0.11 12.9 3.2 3.4 2 1 1 3 3 3 0 Cell division protein ZapB DUF1818 PF08848.11 ORX56800.1 - 0.63 10.1 8.9 0.083 13.0 3.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF1818) FAM76 PF16046.5 ORX56800.1 - 2.9 7.2 15.4 0.54 9.6 4.5 2.2 2 0 0 2 2 2 0 FAM76 protein FapA PF03961.13 ORX56800.1 - 3 6.3 13.7 0.2 10.2 2.8 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A ERM PF00769.19 ORX56800.1 - 7.2 6.3 25.2 0.12 12.2 4.3 3.0 2 1 1 3 3 3 0 Ezrin/radixin/moesin family DUF3450 PF11932.8 ORX56800.1 - 8.1 5.7 18.5 2.2 7.5 2.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF641 PF04859.12 ORX56800.1 - 8.9 6.7 15.1 6.1 7.2 3.2 2.6 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) RhoGEF PF00621.20 ORX56801.1 - 2.2e-16 60.6 6.7 4.1e-16 59.7 6.7 1.5 1 0 0 1 1 1 1 RhoGEF domain CNH PF00780.22 ORX56801.1 - 2e-13 50.6 0.1 2e-13 50.6 0.1 1.7 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 ORX56801.1 - 3.3e-05 24.0 0.8 0.00062 19.9 0.5 3.1 3 1 0 3 3 3 1 Pleckstrin homology domain PH_13 PF16652.5 ORX56801.1 - 0.093 12.5 0.0 4.7 7.0 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_10 PF15411.6 ORX56801.1 - 0.15 12.3 0.0 3.1 8.1 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain DUF1749 PF08538.10 ORX56802.1 - 5.4e-46 157.0 0.1 6.1e-46 156.9 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 ORX56802.1 - 3.7e-07 31.0 0.0 4.4e-07 30.7 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX56802.1 - 1.1e-06 28.1 0.0 7e-06 25.5 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ORX56802.1 - 0.0004 19.9 0.0 0.018 14.5 0.0 2.5 1 1 1 2 2 2 1 Prolyl oligopeptidase family DUF900 PF05990.12 ORX56802.1 - 0.097 12.2 0.1 0.21 11.1 0.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) LysM PF01476.20 ORX56803.1 - 0.00014 21.8 0.0 0.00023 21.2 0.0 1.3 1 0 0 1 1 1 1 LysM domain Herpes_capsid PF06112.11 ORX56803.1 - 6.9 6.7 23.5 12 6.0 23.5 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CRM1_C PF08767.11 ORX56804.1 - 0.0012 18.1 2.9 0.013 14.7 0.7 3.0 3 0 0 3 3 3 2 CRM1 C terminal TPR_1 PF00515.28 ORX56805.1 - 5.8e-63 206.3 23.7 4.8e-07 29.3 0.0 11.1 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ORX56805.1 - 1.2e-56 184.3 20.0 8.6e-06 25.5 0.0 10.3 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 ORX56805.1 - 5.6e-38 126.0 19.5 9.8e-05 22.3 0.0 10.6 10 1 0 10 10 10 8 Tetratricopeptide repeat TPR_14 PF13428.6 ORX56805.1 - 2.8e-32 108.7 9.6 0.00026 21.5 0.1 9.1 4 3 6 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 ORX56805.1 - 3.8e-29 100.1 24.9 1.1e-05 25.0 0.1 9.4 4 2 5 9 9 9 6 TPR repeat TPR_7 PF13176.6 ORX56805.1 - 5.3e-28 95.0 11.3 0.0016 18.3 0.1 9.5 9 1 1 10 10 9 7 Tetratricopeptide repeat TPR_12 PF13424.6 ORX56805.1 - 7.1e-27 93.5 21.2 2.7e-06 27.5 4.1 8.1 3 3 4 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ORX56805.1 - 6.3e-26 90.8 5.5 2.9e-06 27.8 0.0 6.1 4 2 3 7 7 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 ORX56805.1 - 1.4e-25 87.7 14.1 0.0013 19.0 0.0 9.8 10 1 0 10 10 10 5 Tetratricopeptide repeat TPR_19 PF14559.6 ORX56805.1 - 5.2e-23 81.3 13.7 1.2e-05 25.7 0.6 7.3 3 2 4 8 8 8 7 Tetratricopeptide repeat TPR_6 PF13174.6 ORX56805.1 - 6.3e-22 76.7 13.9 0.0028 18.2 0.0 9.4 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_9 PF13371.6 ORX56805.1 - 2.5e-20 72.4 10.2 8.4e-05 22.6 0.0 7.0 2 2 6 8 8 8 7 Tetratricopeptide repeat TPR_15 PF13429.6 ORX56805.1 - 2.6e-12 46.6 8.5 0.12 11.6 0.6 5.9 1 1 2 5 5 5 5 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX56805.1 - 9.1e-10 38.4 2.7 0.055 12.8 0.1 4.6 2 2 3 5 5 5 4 MalT-like TPR region TPR_10 PF13374.6 ORX56805.1 - 4.1e-08 32.8 18.2 0.49 10.3 0.2 7.3 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_21 PF09976.9 ORX56805.1 - 4.2e-07 29.9 7.6 0.055 13.2 0.0 4.8 5 1 0 5 5 5 2 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 ORX56805.1 - 2.1e-05 24.6 19.2 0.89 9.8 3.8 5.2 3 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 Tcf25 PF04910.14 ORX56805.1 - 0.00014 21.0 0.5 0.027 13.5 0.1 3.3 4 0 0 4 4 4 1 Transcriptional repressor TCF25 MIT PF04212.18 ORX56805.1 - 0.00043 20.3 20.7 14 5.9 0.0 8.3 7 2 2 9 9 9 0 MIT (microtubule interacting and transport) domain RPN13_C PF16550.5 ORX56805.1 - 0.0006 20.0 0.0 0.01 16.0 0.0 2.7 2 1 0 2 2 2 1 UCH-binding domain BTAD PF03704.17 ORX56805.1 - 0.002 18.6 2.7 0.16 12.4 0.8 2.9 2 1 1 3 3 3 1 Bacterial transcriptional activator domain ChAPs PF09295.10 ORX56805.1 - 0.0026 16.8 0.8 1.2 8.1 0.1 2.8 2 1 2 4 4 4 1 ChAPs (Chs5p-Arf1p-binding proteins) ComR_TPR PF18710.1 ORX56805.1 - 0.0033 17.0 8.8 0.21 11.1 0.1 3.9 3 1 1 4 4 4 1 ComR tetratricopeptide DUF5492 PF17596.2 ORX56805.1 - 0.016 15.5 0.1 0.051 13.9 0.1 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5492) DUF2989 PF11207.8 ORX56805.1 - 0.04 13.7 6.5 1.4 8.7 0.1 4.3 1 1 5 6 6 6 0 Protein of unknown function (DUF2989) DUF1965 PF09248.10 ORX56805.1 - 0.35 10.7 6.9 24 4.8 0.0 5.1 4 3 2 6 6 6 0 Domain of unknown function (DUF1965) TPR_20 PF14561.6 ORX56805.1 - 2.4 8.5 6.1 6.9 7.1 0.0 4.0 5 2 1 6 6 5 0 Tetratricopeptide repeat APP_E2 PF12925.7 ORX56805.1 - 2.4 7.8 9.4 4.1 7.1 0.0 3.9 4 1 0 4 4 4 0 E2 domain of amyloid precursor protein SNAP PF14938.6 ORX56805.1 - 3.3 7.0 17.1 6.6 6.1 1.6 5.0 2 2 4 6 6 6 0 Soluble NSF attachment protein, SNAP Sec1 PF00995.23 ORX56806.1 - 5.2e-114 382.6 0.0 7e-114 382.1 0.0 1.1 1 0 0 1 1 1 1 Sec1 family DUF1115 PF06544.12 ORX56807.1 - 3.5e-11 43.4 0.0 5e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) BLUF PF04940.12 ORX56807.1 - 0.07 13.3 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Sensors of blue-light using FAD TPR_1 PF00515.28 ORX56808.1 - 5.1e-10 38.7 0.7 0.012 15.4 0.2 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX56808.1 - 7.7e-07 28.8 3.1 0.027 14.6 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 ORX56808.1 - 0.0033 17.3 0.0 0.02 14.8 0.0 2.4 2 0 0 2 2 2 1 UBA/TS-N domain TPR_12 PF13424.6 ORX56808.1 - 0.036 14.3 3.1 5.2 7.4 0.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DnaJ PF00226.31 ORX56808.1 - 0.073 13.2 0.2 0.21 11.8 0.0 1.9 2 0 0 2 2 2 0 DnaJ domain TPR_9 PF13371.6 ORX56808.1 - 0.073 13.2 0.8 3.5 7.9 0.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat Phostensin PF13914.6 ORX56808.1 - 0.086 13.5 0.2 0.086 13.5 0.2 3.3 4 0 0 4 4 4 0 Phostensin PP1-binding and SH3-binding region TPR_3 PF07720.12 ORX56808.1 - 0.48 10.5 4.2 5.1 7.2 0.3 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX56808.1 - 0.83 9.4 6.1 1.5 8.5 0.1 2.9 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.6 ORX56808.1 - 0.92 10.5 7.5 9.6 7.3 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX56808.1 - 2.3 8.6 4.5 1.1e+02 3.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX56808.1 - 3 8.5 8.3 14 6.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S8e PF01201.22 ORX56809.1 - 1.4e-49 167.8 3.6 2.6e-49 166.9 3.6 1.4 1 0 0 1 1 1 1 Ribosomal protein S8e LodA_N PF17990.1 ORX56809.1 - 0.57 10.1 4.9 0.76 9.7 4.9 1.3 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal E1-E2_ATPase PF00122.20 ORX56810.1 - 8.3e-51 172.1 6.2 8.3e-51 172.1 6.2 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX56810.1 - 1.5e-39 135.6 5.4 1.5e-39 135.6 5.4 2.2 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX56810.1 - 6.7e-23 82.1 4.7 4.5e-18 66.3 0.4 3.5 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX56810.1 - 1e-17 64.0 0.0 2.1e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX56810.1 - 1.8e-11 43.5 0.0 4.5e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX56810.1 - 1.2e-05 25.2 1.6 0.0016 18.2 1.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX56810.1 - 0.0059 17.0 1.1 0.023 15.1 0.0 2.6 3 1 0 3 3 3 1 haloacid dehalogenase-like hydrolase Actin PF00022.19 ORX56811.1 - 4.2e-28 98.1 0.0 3.2e-18 65.5 0.1 2.8 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 ORX56811.1 - 4.4e-14 52.4 0.1 2.2e-13 50.2 0.0 2.0 2 1 0 2 2 2 1 Putative actin-like family MreB_Mbl PF06723.13 ORX56811.1 - 4.9e-06 25.6 0.0 0.0009 18.2 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 ORX56811.1 - 0.0035 17.7 0.0 0.024 15.0 0.0 2.1 2 0 0 2 2 2 1 Cell division protein FtsA zf-Tim10_DDP PF02953.15 ORX56812.1 - 7.7e-21 73.5 2.1 1e-20 73.1 2.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger SDH_sah PF01972.16 ORX56812.1 - 0.065 12.2 0.0 0.075 12.0 0.0 1.0 1 0 0 1 1 1 0 Serine dehydrogenase proteinase zf-C2HCIx2C PF10782.9 ORX56812.1 - 0.15 12.0 3.8 0.75 9.8 3.8 2.0 1 1 0 1 1 1 0 Zinc-finger Methyltransf_25 PF13649.6 ORX56814.1 - 5.2e-07 30.3 0.0 1.8e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX56814.1 - 5.9e-06 26.2 0.1 1.5e-05 24.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX56814.1 - 1.8e-05 25.3 0.0 4.1e-05 24.1 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX56814.1 - 5.5e-05 22.7 0.0 0.0001 21.9 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 ORX56814.1 - 0.026 14.3 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ORX56814.1 - 0.05 14.4 0.0 0.093 13.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain PITH PF06201.13 ORX56815.1 - 4.3e-44 150.4 0.0 5.2e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 PITH domain AAA_7 PF12775.7 ORX56815.1 - 0.097 12.2 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Rieske PF00355.26 ORX56816.1 - 7.7e-12 45.0 0.0 1.7e-11 43.9 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ORX56816.1 - 7.2e-10 39.2 1.9 7.2e-10 39.2 1.9 2.0 2 1 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region SUKH-4 PF14435.6 ORX56816.1 - 0.082 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein G-patch PF01585.23 ORX56818.1 - 1e-08 34.9 0.7 1.7e-08 34.2 0.7 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX56818.1 - 0.03 14.4 0.2 0.063 13.4 0.2 1.5 1 0 0 1 1 1 0 G-patch domain CLIP1_ZNF PF16641.5 ORX56818.1 - 0.18 11.7 1.4 0.36 10.8 1.4 1.5 1 0 0 1 1 1 0 CLIP1 zinc knuckle GATA PF00320.27 ORX56819.1 - 3.6e-16 58.5 3.2 8.8e-16 57.2 3.2 1.7 1 0 0 1 1 1 1 GATA zinc finger Rubredoxin_2 PF18073.1 ORX56819.1 - 0.13 12.0 0.7 6.1 6.7 0.1 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain NVEALA PF14055.6 ORX56820.1 - 0.23 11.5 1.7 1.7 8.7 0.4 2.5 2 0 0 2 2 2 0 NVEALA protein Arteri_Gl PF00951.18 ORX56820.1 - 0.98 9.2 13.9 2 8.2 3.0 2.7 2 1 0 2 2 2 0 Arterivirus GL envelope glycoprotein Sigma_reg_N PF13800.6 ORX56820.1 - 2.4 8.5 8.5 0.49 10.7 1.6 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF4203 PF13886.6 ORX56821.1 - 3.7e-24 85.5 23.4 4.2e-24 85.3 23.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF1294 PF06961.13 ORX56822.1 - 0.19 12.0 0.8 0.41 10.9 0.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1294) Acetyltransf_1 PF00583.25 ORX56823.1 - 9.6e-14 51.6 0.0 1.2e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX56823.1 - 1.6e-08 34.8 0.2 2.4e-08 34.3 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX56823.1 - 2.1e-07 30.9 0.2 2.7e-07 30.5 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX56823.1 - 0.073 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 FR47-like protein Pkinase PF00069.25 ORX56824.1 - 3.3e-69 233.2 0.0 4e-69 232.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56824.1 - 2.3e-36 125.4 0.0 3e-36 125.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX56824.1 - 4.9e-07 29.4 0.1 1.2e-05 24.8 0.0 2.2 1 1 1 2 2 2 1 Kinase-like Pkinase_C PF00433.24 ORX56824.1 - 7.5e-05 23.4 1.4 0.00019 22.1 1.4 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain FTA2 PF13095.6 ORX56824.1 - 0.00017 21.3 0.1 0.75 9.4 0.0 2.6 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX56824.1 - 0.026 14.5 0.1 0.11 12.4 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX56824.1 - 0.095 11.6 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF2098 PF09871.9 ORX56825.1 - 0.0012 19.2 0.6 0.0028 18.0 0.6 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2098) HABP4_PAI-RBP1 PF04774.15 ORX56825.1 - 0.0051 17.7 7.3 0.19 12.6 5.5 3.0 1 1 1 2 2 2 1 Hyaluronan / mRNA binding family DSPc PF00782.20 ORX56826.1 - 9.6e-28 96.6 0.1 5.4e-25 87.8 0.1 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 ORX56826.1 - 0.041 13.6 0.1 0.067 12.9 0.1 1.3 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 ORX56826.1 - 0.074 12.6 0.1 0.11 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Presenilin PF01080.17 ORX56827.1 - 0.091 11.5 2.8 0.1 11.3 2.8 1.2 1 0 0 1 1 1 0 Presenilin Zn_clus PF00172.18 ORX56828.1 - 3.9e-08 33.3 9.4 7.3e-08 32.4 9.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dickkopf_N PF04706.12 ORX56828.1 - 1.9 9.0 9.4 4.5 7.8 9.4 1.6 1 0 0 1 1 1 0 Dickkopf N-terminal cysteine-rich region Ank_2 PF12796.7 ORX56829.1 - 2.9e-20 72.6 0.7 6.1e-13 49.2 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX56829.1 - 2.8e-16 59.6 2.5 4.6e-06 27.1 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX56829.1 - 7.9e-16 56.6 3.8 0.00018 21.7 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ORX56829.1 - 4.3e-13 49.2 4.4 1.2e-07 31.9 0.1 3.8 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX56829.1 - 3.6e-11 43.0 5.8 0.042 14.3 0.0 6.4 6 0 0 6 6 6 3 Ankyrin repeat FUSC PF04632.12 ORX56829.1 - 5.6 5.4 8.2 1.1 7.7 4.3 1.7 2 0 0 2 2 2 0 Fusaric acid resistance protein family Pkinase PF00069.25 ORX56830.1 - 1.1e-53 182.3 0.0 1.6e-53 181.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56830.1 - 2.7e-32 112.1 0.0 4.2e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX56830.1 - 1.1e-05 24.9 0.0 2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX56830.1 - 0.00013 21.4 0.5 0.0003 20.2 0.1 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX56830.1 - 0.013 15.4 1.6 1.9 8.4 0.1 3.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family DUF3613 PF12266.8 ORX56830.1 - 2.9 7.7 8.1 0.16 11.8 1.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3613) DUF1691 PF07950.11 ORX56831.1 - 4.8e-09 36.9 3.3 4.4e-05 24.2 0.1 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF1691) AAA PF00004.29 ORX56832.1 - 6.2e-98 324.3 0.0 4.7e-48 163.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX56832.1 - 2e-28 97.9 8.4 8.7e-14 51.1 0.7 3.0 2 2 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 ORX56832.1 - 4.3e-19 68.5 0.7 1.4e-18 66.8 0.7 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 ORX56832.1 - 2.3e-14 53.4 0.1 8.6e-06 25.6 0.0 3.1 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX56832.1 - 2.1e-13 50.7 0.0 2.9e-07 30.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ORX56832.1 - 4.5e-12 46.3 0.0 7.4e-06 26.2 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ORX56832.1 - 7.6e-12 45.4 0.2 1.3e-05 25.2 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 ORX56832.1 - 2.7e-11 43.1 0.0 6.4e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 ORX56832.1 - 4.2e-11 43.5 0.0 0.00085 19.7 0.0 4.2 2 2 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ORX56832.1 - 2.3e-09 37.6 0.1 0.021 15.1 0.0 4.1 3 2 1 4 4 3 2 AAA domain TIP49 PF06068.13 ORX56832.1 - 3.7e-09 36.3 0.0 0.0022 17.3 0.0 2.8 2 0 0 2 2 2 2 TIP49 P-loop domain Mg_chelatase PF01078.21 ORX56832.1 - 5.3e-08 32.5 0.2 0.0044 16.4 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 ORX56832.1 - 2e-07 30.9 0.1 2.2e-05 24.3 0.0 2.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_18 PF13238.6 ORX56832.1 - 2.4e-07 31.4 0.0 0.011 16.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ORX56832.1 - 4.4e-07 29.8 0.0 0.017 14.8 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX56832.1 - 4.8e-07 30.1 0.0 0.018 15.4 0.0 2.7 2 0 0 2 2 2 2 RNA helicase Parvo_NS1 PF01057.17 ORX56832.1 - 1.6e-06 27.4 0.1 0.0056 15.8 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 ORX56832.1 - 1.7e-06 28.1 0.0 0.032 14.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain ATPase PF06745.13 ORX56832.1 - 1.9e-06 27.4 0.2 0.6 9.4 0.0 3.4 3 0 0 3 3 3 2 KaiC AAA_7 PF12775.7 ORX56832.1 - 2.6e-06 27.1 0.0 0.013 15.1 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region DUF815 PF05673.13 ORX56832.1 - 3.8e-06 26.3 0.0 0.0054 15.9 0.0 2.6 2 1 0 2 2 2 2 Protein of unknown function (DUF815) AAA_28 PF13521.6 ORX56832.1 - 4.8e-06 26.9 0.0 0.078 13.2 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_24 PF13479.6 ORX56832.1 - 6.1e-06 26.1 0.0 0.14 11.8 0.0 2.7 2 1 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 ORX56832.1 - 6.9e-06 26.1 0.0 0.045 13.6 0.0 2.7 2 0 0 2 2 2 2 Bacterial dnaA protein Sigma54_activat PF00158.26 ORX56832.1 - 9.6e-06 25.4 0.0 0.39 10.4 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 ORX56832.1 - 3.1e-05 23.6 4.2 0.57 9.7 0.1 4.1 3 2 0 4 4 4 1 AAA domain ABC_tran PF00005.27 ORX56832.1 - 4e-05 24.2 0.0 0.026 15.1 0.0 3.3 2 1 0 2 2 2 1 ABC transporter TsaE PF02367.17 ORX56832.1 - 8.3e-05 22.6 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 ORX56832.1 - 0.0001 22.2 0.0 0.63 9.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ORX56832.1 - 0.00015 22.2 0.0 1.1 9.7 0.0 3.2 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 ORX56832.1 - 0.00016 21.6 0.1 0.15 12.0 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_11 PF13086.6 ORX56832.1 - 0.00023 21.0 0.2 0.9 9.3 0.0 2.7 3 0 0 3 3 3 2 AAA domain ResIII PF04851.15 ORX56832.1 - 0.00025 21.1 0.0 0.15 12.1 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit PhoH PF02562.16 ORX56832.1 - 0.00029 20.3 0.3 0.76 9.2 0.0 2.5 2 0 0 2 2 2 2 PhoH-like protein ATPase_2 PF01637.18 ORX56832.1 - 0.00035 20.6 0.3 1.7 8.5 0.0 3.3 3 1 0 3 3 2 2 ATPase domain predominantly from Archaea DUF2075 PF09848.9 ORX56832.1 - 0.001 18.4 0.0 1.2 8.3 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 ORX56832.1 - 0.0012 18.6 0.4 0.99 9.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX56832.1 - 0.0021 17.3 0.0 1.3 8.3 0.0 2.6 2 0 0 2 2 2 1 Zeta toxin AAA_19 PF13245.6 ORX56832.1 - 0.0033 17.7 2.7 2.2 8.6 0.0 3.7 3 1 1 4 4 3 1 AAA domain NB-ARC PF00931.22 ORX56832.1 - 0.0037 16.5 0.0 0.53 9.4 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain Viral_helicase1 PF01443.18 ORX56832.1 - 0.0055 16.5 0.0 0.15 11.8 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Sigma54_activ_2 PF14532.6 ORX56832.1 - 0.015 15.4 0.0 10 6.3 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 ORX56832.1 - 0.017 15.1 0.4 2.5 8.0 0.0 3.4 3 0 0 3 3 3 0 NTPase Cytidylate_kin PF02224.18 ORX56832.1 - 0.023 14.4 0.0 4.6 6.9 0.0 2.8 2 0 0 2 2 2 0 Cytidylate kinase IPT PF01745.16 ORX56832.1 - 0.026 13.9 0.0 2.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase T2SSE PF00437.20 ORX56832.1 - 0.043 12.9 0.0 2 7.4 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AFG1_ATPase PF03969.16 ORX56832.1 - 0.064 12.1 0.0 7.8 5.3 0.0 2.3 2 0 0 2 2 2 0 AFG1-like ATPase Zot PF05707.12 ORX56832.1 - 0.08 12.6 0.0 3.3 7.3 0.0 2.9 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) SRPRB PF09439.10 ORX56832.1 - 0.088 12.2 0.1 13 5.1 0.0 3.3 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Hydin_ADK PF17213.3 ORX56832.1 - 0.11 12.8 2.0 42 4.3 0.0 3.8 4 0 0 4 4 4 0 Hydin Adenylate kinase-like domain AAA_6 PF12774.7 ORX56832.1 - 0.16 10.9 0.2 9.4 5.1 0.0 2.6 3 0 0 3 3 3 0 Hydrolytic ATP binding site of dynein motor region Leo1 PF04004.13 ORX56833.1 - 3.9e-45 153.7 1.4 3.9e-45 153.7 1.4 2.5 2 0 0 2 2 2 1 Leo1-like protein NOA36 PF06524.12 ORX56833.1 - 0.0011 18.4 13.1 0.0011 18.4 13.1 2.2 2 1 1 3 3 3 1 NOA36 protein BUD22 PF09073.10 ORX56833.1 - 0.9 8.8 37.5 0.25 10.6 21.8 2.2 2 0 0 2 2 2 0 BUD22 ANAPC8 PF04049.13 ORX56834.1 - 8.2e-32 110.2 0.8 8.2e-32 110.2 0.8 2.2 3 0 0 3 3 3 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 ORX56834.1 - 7.1e-18 63.6 19.5 0.00017 21.3 1.4 6.2 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX56834.1 - 1.3e-15 56.3 18.2 0.0037 17.3 0.0 7.6 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX56834.1 - 1.4e-13 50.3 8.6 4.5e-07 29.4 0.8 4.8 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.17 ORX56834.1 - 1.6e-12 46.5 34.5 0.0032 17.5 1.3 8.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX56834.1 - 3.5e-11 43.6 14.0 5e-07 30.3 0.1 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX56834.1 - 2.8e-09 36.7 12.4 0.36 11.3 0.4 6.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX56834.1 - 2.3e-08 33.5 9.4 0.079 13.0 0.1 5.9 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX56834.1 - 2.8e-08 33.9 18.8 1.6e-05 25.1 1.9 5.9 3 1 4 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX56834.1 - 4.1e-08 33.4 14.6 0.27 12.2 0.0 7.8 6 2 3 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX56834.1 - 0.00011 22.7 16.8 0.09 13.3 0.0 6.1 4 1 1 6 6 6 2 Tetratricopeptide repeat ChAPs PF09295.10 ORX56834.1 - 0.0098 14.9 0.9 0.27 10.2 0.0 3.3 1 1 3 4 4 4 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_10 PF13374.6 ORX56834.1 - 0.018 14.9 10.4 12 6.0 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX56834.1 - 0.026 14.8 27.3 0.37 11.0 0.4 5.6 4 1 3 7 7 7 0 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ORX56834.1 - 0.046 13.4 4.4 1.8 8.2 0.0 3.8 4 1 0 4 4 4 0 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ORX56834.1 - 0.067 12.5 3.5 0.051 12.9 0.7 2.1 3 0 0 3 3 3 0 MalT-like TPR region TPR_9 PF13371.6 ORX56834.1 - 0.94 9.7 7.3 0.95 9.7 0.3 3.6 2 1 2 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ORX56834.1 - 2.6 8.9 11.0 5.8 7.7 0.9 5.1 6 0 0 6 6 6 0 Sel1 repeat TPR_6 PF13174.6 ORX56834.1 - 2.9 8.7 20.0 43 5.1 0.0 6.6 8 0 0 8 8 5 0 Tetratricopeptide repeat GIT_SHD PF08518.11 ORX56835.1 - 4.4e-19 67.8 0.7 6.3e-10 38.5 0.0 2.6 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT Jnk-SapK_ap_N PF09744.9 ORX56835.1 - 0.0027 17.9 31.8 0.22 11.7 19.9 2.8 1 1 1 2 2 2 2 JNK_SAPK-associated protein-1 Ycf34 PF10718.9 ORX56835.1 - 0.0049 17.5 0.8 0.022 15.4 0.6 2.2 2 0 0 2 2 2 1 Hypothetical chloroplast protein Ycf34 Pox_A_type_inc PF04508.12 ORX56835.1 - 0.11 12.4 0.3 0.63 10.0 0.2 2.4 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat V_ATPase_I PF01496.19 ORX56835.1 - 0.15 9.9 13.7 0.26 9.2 13.7 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HU-CCDC81_bac_2 PF18175.1 ORX56835.1 - 2.5 8.1 7.6 14 5.6 0.9 2.7 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Herpes_DNAp_acc PF04929.12 ORX56836.1 - 0.38 9.7 2.2 0.47 9.4 2.2 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Yae1_N PF09811.9 ORX56836.1 - 2.3 8.0 25.1 1.8e+04 -4.8 25.1 2.5 1 1 0 1 1 1 0 Essential protein Yae1, N terminal SecY PF00344.20 ORX56837.1 - 8e-69 232.2 11.3 1.1e-68 231.8 11.3 1.2 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 ORX56837.1 - 9e-18 63.8 0.5 2.1e-17 62.6 0.5 1.7 1 0 0 1 1 1 1 Plug domain of Sec61p Cript PF10235.9 ORX56839.1 - 2.9e-27 95.1 8.6 2.9e-27 95.1 8.6 1.6 1 1 1 2 2 2 1 Microtubule-associated protein CRIPT DZR PF12773.7 ORX56839.1 - 0.011 15.7 11.9 0.049 13.7 7.3 2.5 2 1 0 2 2 2 0 Double zinc ribbon DUF2616 PF11077.8 ORX56839.1 - 0.021 14.5 4.9 0.025 14.3 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2616) Rhodanese_C PF12368.8 ORX56839.1 - 0.036 14.4 8.6 0.067 13.6 4.8 2.1 2 0 0 2 2 2 0 Rhodanase C-terminal DUF2039 PF10217.9 ORX56839.1 - 0.05 13.9 18.2 0.9 9.9 18.2 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) PG_binding_4 PF12229.8 ORX56839.1 - 0.13 12.5 0.4 0.19 12.0 0.4 1.1 1 0 0 1 1 1 0 Putative peptidoglycan binding domain Gin PF10764.9 ORX56839.1 - 0.19 11.7 8.3 0.23 11.4 0.1 3.3 2 1 0 2 2 2 0 Inhibitor of sigma-G Gin PLATZ PF04640.14 ORX56839.1 - 1.3 9.6 10.9 0.38 11.4 2.2 2.9 2 1 1 3 3 3 0 PLATZ transcription factor NinF PF05810.12 ORX56839.1 - 1.9 8.4 10.3 16 5.4 0.1 3.0 2 1 1 3 3 3 0 NinF protein PolC_DP2 PF03833.13 ORX56839.1 - 2 6.2 6.2 2.4 5.9 6.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zinc_ribbon_2 PF13240.6 ORX56839.1 - 3.5 7.5 14.2 2.4 8.0 3.6 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Pox_Ag35 PF03286.14 ORX56840.1 - 0.16 11.7 0.2 0.28 10.9 0.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Chs7 PF12271.8 ORX56842.1 - 1.3e-102 343.1 18.2 1.5e-102 342.8 18.2 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Usp PF00582.26 ORX56843.1 - 6.1e-28 98.1 0.0 1.8e-27 96.6 0.0 1.6 1 1 0 1 1 1 1 Universal stress protein family TMF_DNA_bd PF12329.8 ORX56844.1 - 1.1e-12 47.8 19.5 1.1e-12 47.7 9.9 2.7 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding Filament PF00038.21 ORX56844.1 - 0.013 15.1 16.8 0.027 14.1 16.8 1.5 1 0 0 1 1 1 0 Intermediate filament protein KELK PF15796.5 ORX56844.1 - 0.016 15.6 1.0 0.016 15.6 1.0 3.1 1 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase BST2 PF16716.5 ORX56844.1 - 0.024 15.2 10.5 0.024 15.2 10.5 3.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 BBP1_C PF15272.6 ORX56844.1 - 0.027 14.3 11.7 0.052 13.4 11.7 1.5 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal APG6_N PF17675.1 ORX56844.1 - 0.32 11.5 21.8 1.2 9.6 10.4 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region Cob_adeno_trans PF01923.18 ORX56844.1 - 0.47 10.6 5.7 1.5 8.9 3.8 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase CENP-F_leu_zip PF10473.9 ORX56844.1 - 0.57 10.2 18.3 0.15 12.1 11.6 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.15 ORX56844.1 - 1.5 9.0 14.7 23 5.1 14.7 2.4 1 1 0 1 1 1 0 RasGAP C-terminus DUF4472 PF14739.6 ORX56844.1 - 4 8.2 17.3 0.13 13.1 7.3 2.8 2 1 1 3 3 2 0 Domain of unknown function (DUF4472) DUF2203 PF09969.9 ORX56844.1 - 4.6 8.0 7.5 4.4 8.1 4.4 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Tho2 PF11262.8 ORX56844.1 - 7.3 5.7 11.4 0.51 9.5 5.2 1.8 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 FUSC PF04632.12 ORX56844.1 - 8.2 4.8 8.7 14 4.0 8.3 1.6 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF724 PF05266.14 ORX56844.1 - 9.8 6.0 13.5 59 3.4 13.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TMF_TATA_bd PF12325.8 ORX56845.1 - 1.4e-25 89.8 13.3 1.4e-25 89.8 13.3 2.4 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 ORX56845.1 - 0.0021 18.1 19.3 0.013 15.6 4.9 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) KCT2 PF17818.1 ORX56845.1 - 0.057 13.5 0.6 0.08 13.1 0.6 1.2 1 0 0 1 1 1 0 Keratinocyte-associated gene product Golgin_A5 PF09787.9 ORX56845.1 - 0.28 10.6 33.0 0.26 10.7 25.5 2.4 1 1 1 2 2 2 0 Golgin subfamily A member 5 NMD3 PF04981.13 ORX56845.1 - 0.33 10.4 5.4 0.51 9.8 5.4 1.3 1 0 0 1 1 1 0 NMD3 family FlaC_arch PF05377.11 ORX56845.1 - 0.56 10.6 13.8 12 6.4 2.7 4.6 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) Angiomotin_C PF12240.8 ORX56845.1 - 1.2 8.7 32.0 0.071 12.7 10.6 2.8 1 1 2 3 3 3 0 Angiomotin C terminal FUSC PF04632.12 ORX56845.1 - 1.4 7.4 16.4 1.5 7.2 15.9 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family Prominin PF05478.11 ORX56845.1 - 1.9 6.3 17.2 2.7 5.8 17.2 1.2 1 0 0 1 1 1 0 Prominin PMC2NT PF08066.12 ORX56845.1 - 2.2 9.0 11.5 0.92 10.2 5.4 2.8 1 1 1 2 2 2 0 PMC2NT (NUC016) domain Lipoprotein_6 PF01441.19 ORX56845.1 - 2.9 7.9 9.2 0.48 10.4 0.5 2.4 1 1 1 2 2 2 0 Lipoprotein DUF812 PF05667.11 ORX56845.1 - 3 6.6 27.3 9.3 5.0 27.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) CENP-H PF05837.12 ORX56845.1 - 3.2 8.2 28.0 0.84 10.1 8.3 2.6 2 1 0 2 2 2 0 Centromere protein H (CENP-H) CC2-LZ PF16516.5 ORX56845.1 - 3.5 8.0 29.4 3.6 8.0 2.7 3.0 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YtxH PF12732.7 ORX56845.1 - 3.7 8.2 11.3 4.9e+03 -1.9 11.3 3.4 1 1 0 1 1 1 0 YtxH-like protein DUF4407 PF14362.6 ORX56845.1 - 4.2 6.6 27.2 1.9 7.8 13.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4239 PF14023.6 ORX56845.1 - 4.2 7.0 9.6 0.82 9.4 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) DUF1284 PF06935.11 ORX56845.1 - 4.8 7.7 7.5 5.9 7.4 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1284) DUF3584 PF12128.8 ORX56845.1 - 5.1 4.5 33.5 6.5 4.1 33.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 ORX56845.1 - 6.2 7.2 14.9 11 6.3 1.5 3.3 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Rootletin PF15035.6 ORX56845.1 - 7.4 6.5 32.3 4.3 7.3 27.3 2.4 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Syntaxin-6_N PF09177.11 ORX56845.1 - 8 7.1 19.1 0.15 12.7 5.7 2.5 2 1 1 3 3 2 0 Syntaxin 6, N-terminal NAS PF03059.16 ORX56846.1 - 2.3e-53 181.3 0.8 1.9e-52 178.3 0.8 1.9 1 1 0 1 1 1 1 Nicotianamine synthase protein Methyltransf_31 PF13847.6 ORX56846.1 - 0.0022 17.8 0.0 0.05 13.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Pkinase PF00069.25 ORX56847.1 - 1.2e-63 214.9 0.0 1.6e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56847.1 - 4e-33 114.8 0.0 5.6e-33 114.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX56847.1 - 1.1e-06 28.2 0.0 2e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX56847.1 - 0.0013 18.2 0.2 0.0021 17.4 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX56847.1 - 0.0023 17.9 0.3 0.0039 17.2 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX56847.1 - 0.0044 15.8 0.0 0.0077 15.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX56847.1 - 0.071 12.0 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase PF00069.25 ORX56848.1 - 3.6e-67 226.5 0.0 4.4e-67 226.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56848.1 - 1.1e-30 106.8 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX56848.1 - 0.0011 18.0 0.1 0.002 17.2 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX56848.1 - 0.0014 18.0 1.0 0.0017 17.8 0.2 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX56848.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Kinase-like S_100 PF01023.19 ORX56848.1 - 0.078 12.7 0.7 0.21 11.3 0.7 1.8 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain Pkinase_fungal PF17667.1 ORX56848.1 - 0.092 11.5 0.1 0.17 10.7 0.0 1.3 1 1 0 1 1 1 0 Fungal protein kinase ATP-synt_10 PF05176.14 ORX56849.1 - 1.7e-53 181.5 0.2 2e-53 181.3 0.2 1.0 1 0 0 1 1 1 1 ATP10 protein RecG_N PF17190.4 ORX56849.1 - 0.083 13.6 3.4 6 7.7 0.0 3.1 2 1 1 3 3 3 0 RecG N-terminal helical domain SET PF00856.28 ORX56850.1 - 5.3e-17 62.7 0.3 4.4e-16 59.7 0.3 2.3 1 1 0 1 1 1 1 SET domain AWS PF17907.1 ORX56850.1 - 9.5e-17 60.7 11.2 9.5e-17 60.7 11.2 2.4 3 0 0 3 3 3 1 AWS domain GATA PF00320.27 ORX56850.1 - 2.4e-12 46.2 2.6 6.5e-12 44.8 2.6 1.8 1 0 0 1 1 1 1 GATA zinc finger RRM_1 PF00076.22 ORX56851.1 - 4.4e-13 48.8 0.0 5.7e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOG1_N PF17835.1 ORX56852.1 - 8.3e-56 188.4 2.3 8.3e-56 188.4 2.3 1.8 2 0 0 2 2 2 1 NOG1 N-terminal helical domain NOGCT PF08155.11 ORX56852.1 - 1.7e-29 101.5 0.8 4.7e-29 100.1 0.8 1.8 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 ORX56852.1 - 2.1e-28 97.9 0.2 2.1e-28 97.9 0.2 1.8 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 ORX56852.1 - 1.3e-18 67.2 0.0 3.9e-18 65.6 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX56852.1 - 5.5e-10 39.0 0.0 1.2e-09 37.9 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX56852.1 - 0.00034 20.6 0.2 0.36 10.7 0.0 3.1 2 1 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ORX56852.1 - 0.00063 19.8 1.7 0.67 10.0 0.0 3.5 2 1 0 3 3 3 2 Dynamin family AIG1 PF04548.16 ORX56852.1 - 0.0047 16.3 0.0 0.011 15.0 0.0 1.7 1 0 0 1 1 1 1 AIG1 family Roc PF08477.13 ORX56852.1 - 0.0074 16.5 0.0 0.088 13.0 0.0 2.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ORX56852.1 - 0.023 15.1 0.0 0.12 12.8 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain GTP_EFTU PF00009.27 ORX56852.1 - 0.046 13.2 0.2 2.3 7.7 0.1 3.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ORX56852.1 - 0.42 11.2 3.6 4.8 7.7 0.0 3.8 4 1 0 4 4 3 0 AAA domain G-alpha PF00503.20 ORX56852.1 - 1 8.4 7.9 0.23 10.6 0.1 3.2 3 1 0 4 4 4 0 G-protein alpha subunit Rad17 PF03215.15 ORX56853.1 - 1.9e-23 83.3 0.0 7.2e-22 78.2 0.0 2.1 1 1 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 ORX56853.1 - 2.8e-07 31.0 0.0 4.8e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX56853.1 - 0.0028 18.1 0.3 0.033 14.6 0.3 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 ORX56853.1 - 0.12 12.5 0.0 0.2 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain Ring_hydroxyl_A PF00848.19 ORX56854.1 - 0.074 13.0 0.7 2.2 8.2 0.2 2.1 2 0 0 2 2 2 0 Ring hydroxylating alpha subunit (catalytic domain) MFS_2 PF13347.6 ORX56855.1 - 3.2e-08 32.6 18.6 1.8e-07 30.1 18.6 2.0 1 1 0 1 1 1 1 MFS/sugar transport protein Chitin_synth_2 PF03142.15 ORX56856.1 - 7.7e-236 783.8 1.6 1.1e-235 783.2 1.6 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_tranf_2_3 PF13641.6 ORX56856.1 - 3.1e-12 46.9 0.0 7.7e-12 45.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX56856.1 - 9e-12 45.3 2.9 2.8e-11 43.7 2.9 1.9 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 ORX56856.1 - 0.00024 20.6 0.2 0.0051 16.3 0.1 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX56856.1 - 0.033 14.0 0.0 2 8.2 0.0 2.4 2 0 0 2 2 2 0 Glycosyl transferase family 2 CUE PF02845.16 ORX56857.1 - 3.3e-13 49.0 0.5 7.3e-13 47.9 0.0 1.9 2 0 0 2 2 2 1 CUE domain RNA_pol_Rpb2_6 PF00562.28 ORX56858.1 - 1.9e-112 376.2 0.0 5.3e-112 374.7 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ORX56858.1 - 2.2e-33 115.5 0.0 3.9e-33 114.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ORX56858.1 - 3.6e-28 97.5 0.0 9.8e-28 96.1 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_7 PF04560.20 ORX56858.1 - 3.5e-22 78.6 0.1 8e-22 77.4 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 ORX56858.1 - 2.7e-21 76.1 0.0 4.6e-21 75.3 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 ORX56858.1 - 1.8e-20 72.7 0.0 3.8e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain Meiotic_rec114 PF03525.14 ORX56858.1 - 0.037 13.0 0.1 1.6 7.7 0.1 2.3 2 0 0 2 2 2 0 Meiotic recombination protein rec114 FYVE PF01363.21 ORX56858.1 - 1.8 8.8 4.6 4.7 7.4 4.6 1.6 1 0 0 1 1 1 0 FYVE zinc finger Pkinase PF00069.25 ORX56859.1 - 5.2e-26 91.6 0.0 6.7e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX56859.1 - 1.2e-10 41.2 0.0 2.2e-10 40.2 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX56859.1 - 2.4e-08 33.2 0.0 3.4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX56859.1 - 0.00054 19.9 0.2 0.027 14.4 0.0 2.4 2 1 0 3 3 3 1 Phosphotransferase enzyme family DUF4214 PF13946.6 ORX56859.1 - 0.18 11.9 0.0 0.34 11.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4214) Glyco_transf_22 PF03901.17 ORX56860.1 - 1.1e-55 189.5 19.9 1.8e-55 188.9 19.9 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Kinesin PF00225.23 ORX56866.1 - 1.7e-20 73.2 0.0 1.6e-14 53.6 0.0 2.3 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ORX56866.1 - 0.00011 22.2 0.0 0.00024 21.1 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Peptidase_M20 PF01546.28 ORX56867.1 - 9.3e-31 107.1 0.0 1.2e-30 106.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ORX56867.1 - 1.6e-11 44.1 0.0 2.9e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain dUTPase PF00692.19 ORX56868.1 - 5e-47 158.8 0.0 5.7e-47 158.6 0.0 1.0 1 0 0 1 1 1 1 dUTPase TAFII28 PF04719.14 ORX56869.1 - 5.9e-34 116.0 0.2 6.5e-34 115.9 0.2 1.0 1 0 0 1 1 1 1 hTAFII28-like protein conserved region GvpK PF05121.12 ORX56869.1 - 0.097 12.7 1.5 1.1 9.4 0.1 2.1 1 1 1 2 2 2 0 Gas vesicle protein K Kei1 PF08552.11 ORX56870.1 - 0.07 13.0 0.3 0.07 13.0 0.3 2.7 2 1 1 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 Glyco_hydro_125 PF06824.11 ORX56871.1 - 7.2e-152 506.1 0.0 8.4e-152 505.9 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Gly_transf_sug PF04488.15 ORX56872.1 - 7.9e-12 45.7 0.1 2.5e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ORX56872.1 - 0.00014 21.3 0.0 0.00023 20.6 0.0 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein TcdA_TcdB PF12919.7 ORX56872.1 - 0.0026 17.1 0.1 0.0056 16.0 0.1 1.4 1 0 0 1 1 1 1 TcdA/TcdB catalytic glycosyltransferase domain Asp PF00026.23 ORX56873.1 - 5.8e-49 167.2 0.5 2.2e-23 83.2 0.0 2.1 2 0 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX56873.1 - 1.2e-08 35.4 0.7 7.7e-07 29.5 0.7 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Actin PF00022.19 ORX56874.1 - 2e-82 277.0 0.0 2.7e-81 273.3 0.0 2.1 1 1 0 1 1 1 1 Actin Ecl1 PF12855.7 ORX56876.1 - 0.0011 20.2 4.3 0.0019 19.4 4.3 1.3 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF1838 PF08894.11 ORX56877.1 - 1.9e-69 233.9 0.3 2.2e-69 233.7 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1838) Histone PF00125.24 ORX56878.1 - 5.2e-52 175.7 2.8 5.7e-52 175.5 2.8 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ORX56878.1 - 1.4e-05 25.4 0.0 2.1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ORX56878.1 - 7.4e-05 22.8 0.5 0.00013 22.0 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ORX56878.1 - 0.00014 22.5 1.7 0.00017 22.2 1.7 1.1 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 ORX56878.1 - 0.0015 18.8 0.1 0.0028 17.9 0.1 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX56878.1 - 0.017 15.2 0.2 0.027 14.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ORX56878.1 - 0.019 14.9 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated TB2_DP1_HVA22 PF03134.19 ORX56879.1 - 1.2e-21 76.4 8.7 1.2e-21 76.4 8.7 2.0 2 0 0 2 2 2 1 TB2/DP1, HVA22 family NRIP1_repr_1 PF15687.5 ORX56879.1 - 0.022 14.4 1.4 0.022 14.4 1.4 1.5 2 0 0 2 2 2 0 Nuclear receptor-interacting protein 1 repression 1 DNA_pol_delta_4 PF04081.13 ORX56880.1 - 3.1e-26 92.3 1.9 4.6e-26 91.7 1.9 1.3 1 0 0 1 1 1 1 DNA polymerase delta, subunit 4 ANAPC4 PF12896.7 ORX56881.1 - 7.6e-31 107.2 5.0 1.2e-30 106.6 4.5 1.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 ORX56881.1 - 8e-05 22.9 0.0 0.00027 21.2 0.0 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain RNase_P_Rpp14 PF01900.19 ORX56882.1 - 1.6e-21 76.5 0.0 3.6e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 Rpp14/Pop5 family GHMP_kinases_N PF00288.26 ORX56882.1 - 6.2e-10 39.2 0.0 1.4e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX56882.1 - 0.00034 20.9 0.0 0.00089 19.6 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal RCC1 PF00415.18 ORX56883.1 - 3.1e-47 159.0 23.0 1.2e-13 51.4 0.2 8.5 7 3 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX56883.1 - 4.8e-27 93.2 45.3 2e-10 40.2 1.4 8.5 7 2 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat Aldolase_II PF00596.21 ORX56883.1 - 0.022 14.7 0.0 0.045 13.7 0.0 1.6 1 0 0 1 1 1 0 Class II Aldolase and Adducin N-terminal domain NmrA PF05368.13 ORX56884.1 - 8.3e-46 156.4 0.0 1.1e-45 156.0 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX56884.1 - 2.2e-23 83.1 0.0 3.1e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX56884.1 - 1.2e-05 24.9 0.1 6.5e-05 22.5 0.1 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 ORX56884.1 - 2.7e-05 24.6 0.2 6.3e-05 23.5 0.2 1.6 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.19 ORX56884.1 - 0.013 14.5 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family FH2 PF02181.23 ORX56884.1 - 0.034 13.3 0.1 0.043 12.9 0.1 1.1 1 0 0 1 1 1 0 Formin Homology 2 Domain Phage_HK97_TLTM PF06120.11 ORX56884.1 - 0.073 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Tail length tape measure protein SR-25 PF10500.9 ORX56885.1 - 4.1e-06 26.6 5.9 6.8e-06 25.9 5.9 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein baeRF_family12 PF18856.1 ORX56885.1 - 0.0029 18.2 1.9 0.0075 16.9 1.9 1.7 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 12 DUF755 PF05501.11 ORX56885.1 - 0.012 15.8 12.6 0.012 15.8 12.6 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF755) YqzE PF14038.6 ORX56885.1 - 0.06 13.4 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 YqzE-like protein Tfb2 PF03849.14 ORX56886.1 - 4.6e-144 479.8 4.0 5.4e-144 479.5 4.0 1.0 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ORX56886.1 - 3e-20 72.4 0.1 7.3e-20 71.2 0.1 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 ORX56886.1 - 0.0032 17.6 0.0 0.0076 16.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Dus PF01207.17 ORX56887.1 - 6.4e-82 275.1 0.0 8e-82 274.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) SOR_SNZ PF01680.17 ORX56887.1 - 1.6e-05 24.8 0.4 3e-05 23.9 0.4 1.5 1 1 0 1 1 1 1 SOR/SNZ family DHO_dh PF01180.21 ORX56887.1 - 0.0025 17.1 0.0 0.0042 16.4 0.0 1.3 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ORX56887.1 - 0.0027 16.8 0.1 0.0043 16.1 0.1 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 ORX56887.1 - 0.0058 16.1 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ORX56887.1 - 0.014 14.9 0.1 0.047 13.2 0.1 1.6 1 1 0 1 1 1 0 Histidine biosynthesis protein PDCD7 PF16021.5 ORX56887.1 - 0.063 12.4 0.2 0.1 11.7 0.2 1.2 1 0 0 1 1 1 0 Programmed cell death protein 7 PdxJ PF03740.13 ORX56887.1 - 0.14 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ ThiG PF05690.14 ORX56887.1 - 0.14 11.4 0.1 0.29 10.4 0.1 1.5 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Beta-TrCP_D PF12125.8 ORX56889.1 - 0.86 9.6 2.9 1.2e+02 2.6 0.0 3.9 3 0 0 3 3 3 0 D domain of beta-TrCP ECF_trnsprt PF12822.7 ORX56891.1 - 0.014 15.6 0.5 0.021 15.0 0.5 1.2 1 0 0 1 1 1 0 ECF transporter, substrate-specific component COX15-CtaA PF02628.15 ORX56891.1 - 0.03 13.4 0.3 0.5 9.4 0.0 2.1 2 0 0 2 2 2 0 Cytochrome oxidase assembly protein WD40 PF00400.32 ORX56892.1 - 2.4e-68 224.3 26.4 1.6e-10 41.4 0.1 8.9 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX56892.1 - 5.7e-26 90.6 6.0 1.2e-05 25.5 0.1 6.4 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain NLE PF08154.12 ORX56892.1 - 5.4e-15 55.7 0.1 1.1e-14 54.6 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 ORX56892.1 - 2e-11 43.5 0.3 0.02 13.9 0.0 5.4 3 3 3 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ORX56892.1 - 1.7e-09 37.8 1.3 0.015 15.2 0.0 3.4 3 1 0 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ORX56892.1 - 1.6e-07 31.0 1.9 0.043 13.1 0.0 4.7 2 2 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ORX56892.1 - 2.3e-07 29.8 5.9 0.72 8.4 0.1 5.8 5 1 1 6 6 6 2 Nucleoporin Nup120/160 PD40 PF07676.12 ORX56892.1 - 0.00017 21.4 2.6 2.9 7.9 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ORX56892.1 - 0.0057 15.2 0.4 0.31 9.5 0.0 3.2 2 2 2 4 4 4 1 Cytochrome D1 heme domain Frtz PF11768.8 ORX56892.1 - 0.017 13.4 0.0 3.6 5.8 0.0 2.6 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 ORX56892.1 - 0.029 14.1 0.5 4 7.1 0.1 2.8 3 0 0 3 3 3 0 TUP1-like enhancer of split WD40_like PF17005.5 ORX56892.1 - 0.034 13.5 0.0 17 4.6 0.0 3.7 4 0 0 4 4 4 0 WD40-like domain Coatomer_WDAD PF04053.14 ORX56892.1 - 0.06 12.4 0.1 0.96 8.4 0.0 2.3 2 0 0 2 2 2 0 Coatomer WD associated region IKI3 PF04762.12 ORX56892.1 - 0.082 10.9 1.2 5.6 4.8 0.0 2.3 2 0 0 2 2 2 0 IKI3 family Nucleoporin_N PF08801.11 ORX56892.1 - 0.089 11.5 2.3 11 4.6 0.1 3.5 2 1 1 3 3 3 0 Nup133 N terminal like BAR PF03114.18 ORX56893.1 - 6.6e-40 137.3 5.6 8.7e-40 136.8 5.6 1.1 1 0 0 1 1 1 1 BAR domain Arfaptin PF06456.13 ORX56893.1 - 0.012 15.2 0.6 0.012 15.2 0.6 2.1 3 1 0 3 3 3 0 Arfaptin-like domain SHE3 PF17078.5 ORX56893.1 - 0.34 10.6 10.6 3.5 7.3 0.1 3.0 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 Occludin_ELL PF07303.13 ORX56893.1 - 1.9 9.2 12.3 1.5 9.6 3.7 3.3 2 1 1 3 3 3 0 Occludin homology domain MIT PF04212.18 ORX56894.1 - 1.7e-08 34.4 1.1 3.6e-08 33.4 1.1 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF4452 PF14618.6 ORX56895.1 - 0.00024 21.0 14.3 0.089 12.6 14.3 2.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4452) NTP_transferase PF00483.23 ORX56896.1 - 2.3e-13 50.3 0.0 5.1e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ORX56896.1 - 6.3e-08 33.1 0.0 8.4e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 ORX56896.1 - 1.8e-07 30.6 15.7 0.014 15.1 11.3 4.3 2 1 1 4 4 4 3 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 ORX56896.1 - 9.1e-05 20.8 3.4 0.00013 20.3 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 ORX56896.1 - 0.06 12.3 4.9 0.23 10.4 4.9 1.8 1 1 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 ORX56896.1 - 0.16 11.8 9.5 0.69 9.7 7.2 2.9 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase SMN PF06003.12 ORX56897.1 - 9.3e-07 28.4 0.1 1.5e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) TUDOR PF00567.24 ORX56897.1 - 4.9e-05 23.3 0.0 8.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Tudor domain DUF4537 PF15057.6 ORX56897.1 - 0.00021 21.3 0.0 0.00042 20.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) Tudor_2 PF18104.1 ORX56897.1 - 0.0012 18.5 0.1 0.0026 17.4 0.1 1.6 1 0 0 1 1 1 1 Jumonji domain-containing protein 2A Tudor domain DUF1325 PF07039.11 ORX56897.1 - 0.013 15.6 0.4 0.038 14.1 0.0 1.9 2 1 0 2 2 2 0 SGF29 tudor-like domain 53-BP1_Tudor PF09038.10 ORX56897.1 - 0.032 14.2 0.1 0.068 13.1 0.0 1.6 2 0 0 2 2 2 0 Tumour suppressor p53-binding protein-1 Tudor DUF150_C PF17384.2 ORX56897.1 - 0.29 11.3 3.5 0.38 10.9 0.0 2.3 2 1 1 3 3 3 0 RimP C-terminal SH3 domain Sds3 PF08598.11 ORX56898.1 - 2.1e-14 54.1 16.0 3.9e-14 53.2 16.0 1.4 1 1 0 1 1 1 1 Sds3-like zf-RING_2 PF13639.6 ORX56899.1 - 9.2e-13 48.3 5.2 9.2e-13 48.3 5.2 1.9 2 0 0 2 2 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX56899.1 - 4.9e-10 39.0 1.9 4.9e-10 39.0 1.9 2.7 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX56899.1 - 1.8e-09 37.3 0.7 1.8e-09 37.3 0.7 1.9 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX56899.1 - 3.9e-08 33.0 5.4 9e-08 31.8 5.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PA PF02225.22 ORX56899.1 - 6.9e-06 26.0 0.0 1.5e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 PA domain zf-rbx1 PF12678.7 ORX56899.1 - 8.8e-06 25.9 8.1 4.2e-05 23.8 8.1 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX56899.1 - 2.6e-05 24.1 2.9 2.6e-05 24.1 2.9 1.9 1 1 0 1 1 1 1 zinc-RING finger domain RicinB_lectin_2 PF14200.6 ORX56899.1 - 3.7e-05 24.4 6.2 0.0041 17.8 2.9 2.0 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like zf-RING_UBOX PF13445.6 ORX56899.1 - 8.2e-05 22.6 3.7 0.00012 22.0 0.3 2.4 1 1 1 2 2 2 1 RING-type zinc-finger Ricin_B_lectin PF00652.22 ORX56899.1 - 0.0033 17.7 0.9 0.013 15.8 0.6 2.0 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain zf-C3HC4_3 PF13920.6 ORX56899.1 - 0.0051 16.6 7.4 0.01 15.7 7.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX56899.1 - 0.013 15.6 6.0 0.036 14.1 6.0 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ORX56899.1 - 0.019 14.8 8.3 0.043 13.7 8.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ORX56899.1 - 0.1 12.4 4.6 0.21 11.4 4.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain PHD PF00628.29 ORX56899.1 - 0.49 10.3 8.7 0.14 12.1 5.0 2.1 2 1 0 2 2 1 0 PHD-finger RINGv PF12906.7 ORX56899.1 - 1.2 9.4 7.1 0.75 10.0 3.8 2.4 2 0 0 2 2 2 0 RING-variant domain Ribosomal_L33 PF00471.20 ORX56899.1 - 1.4 9.4 3.8 3.5 8.2 3.8 1.6 1 0 0 1 1 1 0 Ribosomal protein L33 Zn_ribbon_17 PF17120.5 ORX56899.1 - 6.2 6.5 11.7 0.94 9.2 6.1 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type MFS_1 PF07690.16 ORX56900.1 - 1.7e-38 132.4 32.7 1.7e-38 132.4 32.7 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX56900.1 - 2.5e-10 39.8 13.2 2.5e-10 39.8 13.2 2.3 1 1 1 2 2 2 1 Sugar (and other) transporter F-box PF00646.33 ORX56901.1 - 8.2e-10 38.3 0.3 1.8e-09 37.2 0.3 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX56901.1 - 4.4e-06 26.5 2.7 9.1e-06 25.5 2.7 1.5 1 0 0 1 1 1 1 F-box-like Furin-like_2 PF15913.5 ORX56901.1 - 0.14 12.3 0.6 0.31 11.2 0.1 1.7 2 0 0 2 2 2 0 Furin-like repeat, cysteine-rich UCH_1 PF13423.6 ORX56902.1 - 7.2e-05 22.5 0.1 0.00074 19.2 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3514 PF12027.8 ORX56902.1 - 0.18 11.5 0.1 0.29 10.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) zf-RING_2 PF13639.6 ORX56903.1 - 3.1e-13 49.8 7.9 5.8e-13 48.9 7.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ORX56903.1 - 1.3e-10 40.8 4.2 3.6e-10 39.4 4.2 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX56903.1 - 2.8e-08 33.5 8.1 5.5e-08 32.5 8.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX56903.1 - 4.4e-07 29.7 7.0 9.4e-07 28.6 7.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX56903.1 - 5.3e-07 29.8 6.0 1.5e-06 28.4 6.0 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX56903.1 - 0.00024 21.1 3.5 0.00024 21.1 3.5 2.0 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX56903.1 - 0.0011 18.8 8.6 0.0021 17.9 8.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX56903.1 - 0.0096 15.9 6.7 0.017 15.0 6.7 1.5 1 0 0 1 1 1 1 zinc-RING finger domain HYLS1_C PF15311.6 ORX56903.1 - 0.031 15.0 0.1 0.066 14.0 0.1 1.5 1 0 0 1 1 1 0 Hydrolethalus syndrome protein 1 C-terminus DUF4410 PF14366.6 ORX56903.1 - 0.15 12.0 0.1 0.27 11.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4410) Prok-RING_4 PF14447.6 ORX56903.1 - 0.15 11.9 11.3 0.33 10.8 11.3 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX56903.1 - 0.28 11.3 6.2 0.89 9.7 6.2 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ORX56903.1 - 2.7 8.2 7.9 5.9 7.1 7.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 ORX56903.1 - 5 6.8 9.4 10 5.8 9.4 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Acatn PF13000.7 ORX56904.1 - 2.7e-169 564.2 25.9 1.8e-87 294.2 13.6 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 Kinesin PF00225.23 ORX56905.1 - 1.7e-105 352.6 0.3 1.7e-105 352.6 0.3 2.0 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX56905.1 - 2.8e-55 186.4 0.0 8.8e-55 184.7 0.0 1.9 1 0 0 1 1 1 1 Microtubule binding Death PF00531.22 ORX56905.1 - 0.082 13.1 4.7 0.19 11.9 4.7 1.7 1 0 0 1 1 1 0 Death domain DUF3584 PF12128.8 ORX56905.1 - 0.19 9.2 23.3 0.24 8.9 23.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 ORX56905.1 - 0.45 10.8 15.7 0.53 10.6 1.0 3.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Atg14 PF10186.9 ORX56905.1 - 0.58 9.2 26.8 0.2 10.7 9.1 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 ORX56905.1 - 1.7 8.1 23.4 1.8 8.1 15.5 2.3 1 1 1 2 2 2 0 Intermediate filament protein Cortex-I_coil PF09304.10 ORX56905.1 - 1.7 8.9 18.0 20 5.4 11.5 3.3 1 1 1 2 2 2 0 Cortexillin I, coiled coil DUF812 PF05667.11 ORX56905.1 - 2.7 6.8 24.2 4.7 6.0 24.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HAUS-augmin3 PF14932.6 ORX56905.1 - 4.7 6.7 27.2 0.56 9.7 13.9 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF5595 PF18077.1 ORX56905.1 - 8.6 6.5 7.5 2.3 8.4 0.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) Auto_anti-p27 PF06677.12 ORX56906.1 - 6.8e-26 90.2 3.3 9.9e-14 51.2 0.2 2.4 2 0 0 2 2 2 2 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CxC6 PF18721.1 ORX56906.1 - 0.032 14.5 0.0 0.032 14.5 0.0 2.9 3 0 0 3 3 3 0 CxC6 like cysteine cluster associated with KDZ transposases DUF1612 PF07756.12 ORX56908.1 - 0.18 12.1 8.0 0.31 11.3 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1612) SWI-SNF_Ssr4 PF08549.10 ORX56908.1 - 0.18 10.4 9.4 0.37 9.4 9.4 1.4 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF728 PF05304.12 ORX56908.1 - 0.75 9.6 3.6 1.2 9.0 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF728) DUF2390 PF09523.10 ORX56908.1 - 7.2 7.0 15.4 5.5 7.4 5.8 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF2390) DUF2894 PF11445.8 ORX56908.1 - 7.5 7.0 13.5 2.4 8.6 0.4 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF2894) DUF1644 PF07800.12 ORX56909.1 - 0.00068 19.7 1.4 0.001 19.2 1.4 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1644) NifQ PF04891.12 ORX56909.1 - 3.1 8.1 9.5 1.6 9.0 1.8 2.3 2 0 0 2 2 2 0 NifQ Oxidored_FMN PF00724.20 ORX56910.1 - 2.9e-95 319.4 0.0 3.3e-95 319.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family CAF1 PF04857.20 ORX56912.1 - 0.12 11.6 0.1 0.14 11.3 0.1 1.0 1 0 0 1 1 1 0 CAF1 family ribonuclease zf-C2H2 PF00096.26 ORX56913.1 - 0.17 12.4 3.3 0.52 10.9 3.3 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Oxidored_FMN PF00724.20 ORX56914.1 - 6.9e-08 32.1 0.0 7.3e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family zf-C2H2_4 PF13894.6 ORX56915.1 - 3.3e-05 24.3 8.5 0.0069 17.1 1.0 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ORX56915.1 - 0.00073 20.2 3.0 0.14 12.8 0.3 2.4 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_2 PF12756.7 ORX56915.1 - 0.0018 18.6 4.0 0.11 12.8 5.0 2.2 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 ORX56915.1 - 0.0027 18.1 7.5 0.07 13.6 0.7 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-MYST PF17772.1 ORX56915.1 - 0.0091 15.6 0.6 0.062 12.9 0.0 2.3 2 0 0 2 2 2 1 MYST family zinc finger domain Actin_micro PF17003.5 ORX56915.1 - 0.011 15.0 0.4 0.17 11.0 0.4 2.2 1 1 0 1 1 1 0 Putative actin-like family FOXP-CC PF16159.5 ORX56915.1 - 0.02 15.5 0.7 4.8 7.9 0.0 2.6 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_9 PF16293.5 ORX56915.1 - 0.043 13.6 0.3 0.043 13.6 0.3 2.0 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) OTT_1508_deam PF14441.6 ORX56915.1 - 0.69 10.0 4.2 18 5.4 1.2 2.5 2 0 0 2 2 2 0 OTT_1508-like deaminase zf-C2H2_jaz PF12171.8 ORX56915.1 - 0.91 9.9 3.9 1.4 9.3 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 ORX56915.1 - 1 9.7 4.0 3 8.2 0.3 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF3658 PF12395.8 ORX56917.1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function FlxA PF14282.6 ORX56917.1 - 0.14 12.2 0.9 0.26 11.3 0.9 1.4 1 0 0 1 1 1 0 FlxA-like protein EMP70 PF02990.16 ORX56918.1 - 3.6e-206 685.9 3.8 5.2e-206 685.3 3.8 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 Cas9_PI2 PF18070.1 ORX56918.1 - 0.025 15.3 0.2 0.22 12.3 0.2 2.3 1 1 1 2 2 2 0 CRISPR-Cas9 PI domain TCTP PF00838.17 ORX56919.1 - 1.6e-73 246.5 0.9 1.8e-73 246.3 0.9 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein RcbX PF02341.15 ORX56919.1 - 0.028 14.7 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 RbcX protein Snf7 PF03357.21 ORX56920.1 - 1.8e-41 141.7 26.0 1.8e-41 141.7 26.0 1.6 2 0 0 2 2 2 1 Snf7 Uds1 PF15456.6 ORX56920.1 - 0.46 10.7 9.2 0.24 11.5 0.4 2.6 3 0 0 3 3 3 0 Up-regulated During Septation Resolvase PF00239.21 ORX56920.1 - 0.92 9.6 10.5 0.18 11.9 4.7 2.5 1 1 1 2 2 2 0 Resolvase, N terminal domain TPR_MLP1_2 PF07926.12 ORX56920.1 - 1.1 9.3 12.9 0.35 10.9 8.1 2.4 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein YlqD PF11068.8 ORX56920.1 - 1.3 9.4 19.4 2.4 8.5 7.9 2.2 1 1 1 2 2 2 0 YlqD protein Allexi_40kDa PF05549.11 ORX56920.1 - 9.7 5.6 7.9 16 4.9 2.1 2.3 1 1 1 2 2 2 0 Allexivirus 40kDa protein RNA_pol_Rpb8 PF03870.15 ORX56921.1 - 3e-52 176.5 0.1 3.4e-52 176.3 0.1 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 ORX56921.1 - 0.00071 19.6 0.6 0.75 9.9 0.1 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G Ribosomal_L1 PF00687.21 ORX56922.1 - 2.5e-28 99.2 0.2 3e-28 99.0 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family MFS_1 PF07690.16 ORX56923.1 - 2.1e-29 102.5 49.2 3.1e-18 65.8 17.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Chitin_synth_2 PF03142.15 ORX56923.1 - 0.72 8.4 2.6 1.1 7.9 2.6 1.2 1 0 0 1 1 1 0 Chitin synthase PRKCSH PF07915.13 ORX56924.1 - 1.9e-11 44.8 0.4 1.9e-11 44.8 0.4 2.4 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH_1 PF13015.6 ORX56924.1 - 0.029 14.1 0.1 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Glucosidase II beta subunit-like protein sCache_like PF16736.5 ORX56924.1 - 0.064 13.3 0.8 0.15 12.2 0.8 1.6 1 0 0 1 1 1 0 Single Cache-like Tma16 PF11176.8 ORX56924.1 - 0.067 13.1 3.5 0.058 13.3 1.0 2.1 3 0 0 3 3 3 0 Translation machinery-associated protein 16 GET2 PF08690.10 ORX56924.1 - 0.85 9.2 15.6 1.6 8.3 15.6 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 Hira PF07569.11 ORX56925.1 - 8.4e-58 195.7 0.1 1.8e-57 194.6 0.1 1.6 1 0 0 1 1 1 1 TUP1-like enhancer of split WD40 PF00400.32 ORX56925.1 - 2e-28 98.0 28.0 5.6e-07 30.2 1.6 7.7 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX56925.1 - 1.2e-15 57.6 2.0 0.00045 20.5 0.2 5.8 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 ORX56925.1 - 2.2e-06 27.4 4.4 7.8e-06 25.6 4.4 2.0 1 0 0 1 1 1 1 HIRA B motif PD40 PF07676.12 ORX56925.1 - 0.0006 19.7 0.0 4.7 7.3 0.0 4.0 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ORX56925.1 - 0.0041 16.1 0.1 15 4.4 0.0 3.9 3 1 0 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX56925.1 - 0.11 11.7 0.0 0.36 10.1 0.0 1.8 1 1 0 1 1 1 0 WD40-like domain LRR_8 PF13855.6 ORX56926.1 - 4.9e-20 71.1 50.1 2.8e-09 36.6 7.9 3.2 1 1 4 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ORX56926.1 - 2.3e-12 46.9 22.2 2.9e-05 24.3 5.9 4.1 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX56926.1 - 2.5e-05 24.2 15.5 1.4 9.8 0.3 6.7 6 1 0 6 6 6 2 Leucine Rich Repeat LRR_9 PF14580.6 ORX56926.1 - 3.2e-05 23.5 6.9 0.0048 16.4 4.5 2.2 1 1 1 2 2 2 2 Leucine-rich repeat LEDGF PF11467.8 ORX56926.1 - 0.14 11.8 0.2 14 5.3 0.1 2.4 2 0 0 2 2 2 0 Lens epithelium-derived growth factor (LEDGF) LRR_3 PF07725.12 ORX56926.1 - 5.2 7.1 7.5 3.1 7.8 1.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat CPP1-like PF11833.8 ORX56927.1 - 0.032 13.9 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Acyltransferase PF01553.21 ORX56928.1 - 5e-05 22.9 0.0 8.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase bZIP_1 PF00170.21 ORX56930.1 - 2.8e-07 30.5 13.5 3.3e-07 30.3 11.1 2.2 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 ORX56930.1 - 1.6e-06 28.1 7.7 1.6e-06 28.1 7.7 2.3 1 1 1 2 2 2 2 Basic region leucine zipper Shugoshin_N PF07558.11 ORX56930.1 - 0.0063 16.4 1.9 0.017 15.0 1.9 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region bZIP_Maf PF03131.17 ORX56930.1 - 0.049 14.2 7.1 0.1 13.2 7.1 1.5 1 0 0 1 1 1 0 bZIP Maf transcription factor TMCO5 PF14992.6 ORX56930.1 - 0.082 12.5 1.7 0.13 11.8 1.7 1.2 1 0 0 1 1 1 0 TMCO5 family ADIP PF11559.8 ORX56930.1 - 2.6 8.1 10.0 0.46 10.6 6.4 1.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Methyltransf_31 PF13847.6 ORX56931.1 - 1.4e-16 60.6 0.0 2.2e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX56931.1 - 4.2e-10 40.2 0.2 3.2e-09 37.3 0.1 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX56931.1 - 4.2e-08 33.7 0.1 1.3e-07 32.2 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX56931.1 - 6.3e-08 33.3 0.0 1.3e-07 32.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX56931.1 - 1.5e-07 31.2 0.2 2.2e-07 30.6 0.2 1.4 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX56931.1 - 3e-07 30.4 0.0 3.8e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ORX56931.1 - 0.00018 21.5 0.0 0.00023 21.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 ORX56931.1 - 0.00062 19.5 0.0 0.0067 16.1 0.0 2.1 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) MetW PF07021.12 ORX56931.1 - 0.0022 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DOT1 PF08123.13 ORX56931.1 - 0.0064 16.0 0.0 0.009 15.6 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_4 PF02390.17 ORX56931.1 - 0.0094 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase TehB PF03848.14 ORX56931.1 - 0.016 14.6 0.0 0.025 14.0 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Ubie_methyltran PF01209.18 ORX56931.1 - 0.03 13.7 0.0 0.044 13.1 0.0 1.4 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 ORX56931.1 - 0.079 12.2 0.0 0.23 10.7 0.0 1.7 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase AviRa PF11599.8 ORX56931.1 - 0.091 12.2 0.3 0.16 11.4 0.3 1.4 1 1 0 1 1 1 0 RRNA methyltransferase AviRa tRNA_U5-meth_tr PF05958.11 ORX56931.1 - 0.12 11.4 0.0 0.15 11.0 0.0 1.3 1 1 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase PrmA PF06325.13 ORX56931.1 - 0.15 11.4 0.1 0.27 10.6 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF5337 PF17272.2 ORX56933.1 - 0.016 15.0 0.2 0.016 15.0 0.2 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5337) TAF4 PF05236.14 ORX56934.1 - 1.3e-22 80.9 0.8 3.7e-20 72.8 0.0 2.7 2 1 1 3 3 3 2 Transcription initiation factor TFIID component TAF4 family SAGA-Tad1 PF12767.7 ORX56934.1 - 0.00065 19.5 0.6 0.00087 19.1 0.6 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit tRNA-synt_2b PF00587.25 ORX56935.1 - 6.6e-36 123.9 0.0 1.2e-35 123.1 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX56935.1 - 1.8e-25 89.2 8.4 1.8e-25 89.2 8.4 1.8 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 ORX56935.1 - 0.19 11.0 2.3 0.3 10.4 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GCR1_C PF12550.8 ORX56935.1 - 0.25 11.7 2.5 0.67 10.3 1.5 2.2 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes Spc24 PF08286.11 ORX56935.1 - 0.73 10.1 5.5 2.9 8.2 5.5 2.0 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DivIC PF04977.15 ORX56935.1 - 3.4 7.5 8.2 8.9 6.2 8.2 1.7 1 0 0 1 1 1 0 Septum formation initiator 60KD_IMP PF02096.20 ORX56936.1 - 4.4e-28 98.3 0.6 6.5e-28 97.7 0.6 1.3 1 0 0 1 1 1 1 60Kd inner membrane protein MFS_1 PF07690.16 ORX56937.1 - 2.7e-49 168.0 47.1 2.7e-49 168.0 47.1 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX56937.1 - 7.6e-13 48.1 15.7 7.6e-13 48.1 15.7 3.0 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 ORX56937.1 - 0.00037 19.5 5.9 0.00037 19.5 5.9 2.9 3 0 0 3 3 3 2 MFS_1 like family CECR6_TMEM121 PF14997.6 ORX56937.1 - 0.041 13.7 2.8 0.69 9.7 0.0 2.4 2 0 0 2 2 2 0 CECR6/TMEM121 family LRR19-TM PF15176.6 ORX56937.1 - 0.18 11.8 4.8 2.7 8.1 0.1 3.3 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Phage_holin_2_4 PF16082.5 ORX56937.1 - 6 6.7 5.9 9.2 6.1 0.4 2.8 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Aconitase PF00330.20 ORX56938.1 - 1.3e-160 535.4 0.0 1.6e-160 535.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX56938.1 - 2e-41 141.4 0.0 3.8e-41 140.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain BK_channel_a PF03493.18 ORX56940.1 - 7.9e-13 48.4 1.0 6.2e-12 45.6 0.0 2.5 2 1 1 3 3 3 1 Calcium-activated BK potassium channel alpha subunit Ion_trans_2 PF07885.16 ORX56940.1 - 1.9e-08 34.1 3.0 4.8e-08 32.9 3.0 1.7 1 0 0 1 1 1 1 Ion channel TrkA_N PF02254.18 ORX56940.1 - 0.0023 18.2 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 2 TrkA-N domain Mob_synth_C PF06463.13 ORX56942.1 - 7e-37 126.2 0.0 1e-36 125.7 0.0 1.3 1 0 0 1 1 1 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 ORX56942.1 - 4.8e-33 114.9 0.0 6.8e-33 114.4 0.0 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 ORX56942.1 - 4.2e-06 27.1 0.0 8.1e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 ORX56942.1 - 0.0038 17.4 0.0 0.011 15.9 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain ThiG PF05690.14 ORX56942.1 - 0.043 13.1 0.0 0.074 12.4 0.0 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG MoaC PF01967.21 ORX56943.1 - 5.5e-51 172.2 7.0 6.5e-51 172.0 7.0 1.1 1 0 0 1 1 1 1 MoaC family TGS PF02824.21 ORX56943.1 - 0.008 16.2 0.3 0.18 11.9 0.0 2.3 2 0 0 2 2 2 1 TGS domain Ribosomal_S25 PF03297.15 ORX56944.1 - 5.6e-39 132.4 5.1 6.1e-39 132.3 5.1 1.0 1 0 0 1 1 1 1 S25 ribosomal protein HTH_24 PF13412.6 ORX56944.1 - 0.0019 17.7 0.4 0.0028 17.2 0.4 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding BioT2 PF15368.6 ORX56944.1 - 0.0026 17.7 0.2 0.0026 17.7 0.2 1.2 1 0 0 1 1 1 1 Spermatogenesis family BioT2 AIPR PF10592.9 ORX56944.1 - 0.0039 16.9 0.6 0.0077 15.9 0.7 1.5 1 1 0 1 1 1 1 AIPR protein HpcH_HpaI PF03328.14 ORX56945.1 - 1.6e-40 138.6 1.3 2.1e-40 138.2 1.3 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 ORX56945.1 - 1.3e-13 50.8 0.2 1.2e-11 44.4 0.0 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold PK PF00224.21 ORX56945.1 - 0.0016 17.4 1.3 0.0028 16.6 0.5 1.7 2 0 0 2 2 2 1 Pyruvate kinase, barrel domain LEA_2 PF03168.13 ORX56946.1 - 0.04 14.4 0.0 0.064 13.8 0.0 1.3 1 0 0 1 1 1 0 Late embryogenesis abundant protein HIT PF01230.23 ORX56947.1 - 5.2e-20 72.0 0.3 6.8e-20 71.6 0.3 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX56947.1 - 5.7e-06 26.8 1.7 1.2e-05 25.8 1.7 1.5 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ORX56947.1 - 0.0084 16.0 3.2 0.029 14.2 3.2 1.9 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 Kelch_4 PF13418.6 ORX56948.1 - 6.3e-11 42.1 8.8 0.34 10.9 0.4 6.0 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX56948.1 - 1.6e-06 28.2 20.9 0.0075 16.5 0.6 5.8 6 0 0 6 6 6 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX56948.1 - 1.8e-05 24.6 19.5 0.0035 17.3 0.1 5.7 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ORX56948.1 - 2.5e-05 24.1 5.8 0.02 14.9 0.0 5.3 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 ORX56948.1 - 8.2e-05 22.8 14.4 0.0075 16.5 0.0 5.9 6 0 0 6 6 6 1 Kelch motif VSP PF03302.13 ORX56948.1 - 0.065 12.1 1.7 0.1 11.5 1.7 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein Kelch_1 PF01344.25 ORX56948.1 - 3.2 7.4 6.5 9.4 5.9 0.3 4.5 5 1 0 5 5 5 0 Kelch motif ELP6 PF09807.9 ORX56949.1 - 2e-44 151.9 0.0 2.5e-44 151.6 0.0 1.1 1 0 0 1 1 1 1 Elongation complex protein 6 Elong_Iki1 PF10483.9 ORX56949.1 - 0.00013 21.6 0.0 0.0002 20.9 0.0 1.3 1 1 0 1 1 1 1 Elongator subunit Iki1 ATPase PF06745.13 ORX56949.1 - 0.068 12.5 0.0 0.093 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC Peptidase_S41 PF03572.18 ORX56950.1 - 4.8e-06 26.2 0.0 1.3e-05 24.8 0.0 1.7 1 1 0 1 1 1 1 Peptidase family S41 Cu-oxidase_2 PF07731.14 ORX56951.1 - 5.9e-11 42.3 6.6 1.4e-09 37.8 4.5 2.9 2 1 0 2 2 2 1 Multicopper oxidase Cu-oxidase_3 PF07732.15 ORX56951.1 - 2.7e-07 30.6 2.6 4e-06 26.8 0.0 2.7 2 2 0 2 2 2 1 Multicopper oxidase Snf7 PF03357.21 ORX56952.1 - 1.9e-35 122.0 22.9 2.7e-35 121.5 22.9 1.2 1 0 0 1 1 1 1 Snf7 DUF424 PF04242.13 ORX56952.1 - 0.066 13.5 1.9 0.13 12.5 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF424) Arg_decarbox_C PF17944.1 ORX56952.1 - 0.13 12.9 0.5 0.13 12.9 0.5 2.3 2 0 0 2 2 2 0 Arginine decarboxylase C-terminal helical extension Forkhead PF00250.18 ORX56953.1 - 2e-32 111.3 0.1 2.2e-32 111.2 0.1 1.0 1 0 0 1 1 1 1 Forkhead domain DUF2992 PF11208.8 ORX56953.1 - 0.11 12.7 0.0 0.14 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) DUF807 PF05660.11 ORX56954.1 - 0.1 12.5 0.0 0.1 12.5 0.0 1.1 1 0 0 1 1 1 0 Coxiella burnetii protein of unknown function (DUF807) DUF1775 PF07987.11 ORX56958.1 - 8.4e-21 74.8 0.4 1.4e-20 74.1 0.4 1.4 1 0 0 1 1 1 1 Domain of unkown function (DUF1775) Biotin_lipoyl PF00364.22 ORX56959.1 - 8.4e-16 57.6 0.5 7.8e-15 54.5 0.2 2.3 2 0 0 2 2 2 1 Biotin-requiring enzyme E3_binding PF02817.17 ORX56959.1 - 2.2e-09 37.5 0.3 6.5e-09 36.0 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 ORX56959.1 - 1.2e-05 25.0 0.1 8.6e-05 22.3 0.0 2.5 2 0 0 2 2 2 1 Biotin-lipoyl like HlyD_3 PF13437.6 ORX56959.1 - 0.0054 17.4 0.3 0.026 15.2 0.0 2.2 2 0 0 2 2 2 1 HlyD family secretion protein Cyclin PF08613.11 ORX56960.1 - 7.5e-16 58.9 0.3 9.1e-16 58.6 0.3 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX56960.1 - 2e-08 34.0 0.3 2.3e-08 33.8 0.3 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain DUF2362 PF10154.9 ORX56961.1 - 1.4e-52 179.3 17.6 1.3e-22 80.4 0.0 4.1 2 1 1 4 4 4 3 Uncharacterized conserved protein (DUF2362) UBA PF00627.31 ORX56961.1 - 1.2e-06 28.3 0.0 3.6e-06 26.8 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain ubiquitin PF00240.23 ORX56962.1 - 2.6e-19 68.7 0.1 4.3e-19 68.0 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 ORX56962.1 - 1.6e-09 37.5 1.8 2.8e-09 36.7 0.8 2.1 2 0 0 2 2 2 1 UBA/TS-N domain Rad60-SLD PF11976.8 ORX56962.1 - 2.1e-09 37.0 0.2 5.3e-09 35.8 0.3 1.6 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ORX56962.1 - 0.0028 17.6 0.0 0.0063 16.4 0.0 1.5 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ORX56962.1 - 0.0034 17.9 0.2 0.0071 16.9 0.0 1.6 2 0 0 2 2 1 1 DUF2407 ubiquitin-like domain STI1 PF17830.1 ORX56962.1 - 0.0081 16.1 18.7 0.14 12.1 3.7 3.7 2 1 0 3 3 3 2 STI1 domain CUE PF02845.16 ORX56962.1 - 0.0087 15.7 0.0 0.022 14.5 0.0 1.7 1 0 0 1 1 1 1 CUE domain Rad60-SLD_2 PF13881.6 ORX56962.1 - 0.014 15.5 0.0 0.029 14.5 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like RPN13_C PF16550.5 ORX56962.1 - 0.033 14.4 5.8 0.036 14.2 2.2 2.4 2 0 0 2 2 2 0 UCH-binding domain GerD PF17898.1 ORX56962.1 - 0.072 13.0 6.9 0.049 13.6 2.5 2.6 2 1 1 3 3 3 0 Spore germination GerD central core domain Med31 PF05669.12 ORX56962.1 - 0.098 12.7 0.1 0.71 9.9 0.0 2.1 2 0 0 2 2 2 0 SOH1 Ubiquitin_4 PF18036.1 ORX56962.1 - 0.1 12.6 0.4 0.28 11.3 0.4 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ORX56962.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain HOIP-UBA PF16678.5 ORX56962.1 - 0.21 11.6 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 HOIP UBA domain pair L27_2 PF09045.10 ORX56962.1 - 0.23 11.4 1.2 0.74 9.8 0.2 2.3 2 0 0 2 2 2 0 L27_2 RNA_polI_A34 PF08208.11 ORX56963.1 - 3.9e-23 82.6 2.0 4.9e-23 82.3 2.0 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Palm_thioest PF02089.15 ORX56964.1 - 4.9e-07 29.8 0.1 1e-06 28.8 0.1 1.4 1 1 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 ORX56964.1 - 2.3e-06 27.2 0.0 4.9e-06 26.1 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) PGAP1 PF07819.13 ORX56964.1 - 4.6e-06 26.5 0.0 7.1e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_1 PF00561.20 ORX56964.1 - 2.7e-05 24.0 0.1 0.00056 19.6 0.1 2.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX56964.1 - 0.00075 20.2 0.1 0.0012 19.5 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.15 ORX56964.1 - 0.0041 16.3 0.0 0.0077 15.4 0.0 1.4 1 1 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 ORX56964.1 - 0.0044 16.6 0.0 0.0073 15.8 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF900 PF05990.12 ORX56964.1 - 0.078 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) DUF5600 PF18150.1 ORX56965.1 - 3.8e-37 127.1 1.9 7.7e-37 126.1 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ORX56965.1 - 3.3e-18 65.5 0.0 1.8e-17 63.2 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EHD_N PF16880.5 ORX56965.1 - 2.4e-14 52.9 0.0 4.5e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 ORX56965.1 - 7e-14 52.2 0.0 9.8e-13 48.5 0.0 2.2 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ORX56965.1 - 7.7e-08 32.4 0.0 2.2e-07 31.0 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX56965.1 - 2.3e-05 24.1 0.0 8.9e-05 22.1 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EF-hand_1 PF00036.32 ORX56965.1 - 0.00014 21.2 0.0 0.00075 18.9 0.0 2.4 3 0 0 3 3 2 1 EF hand Gtr1_RagA PF04670.12 ORX56965.1 - 0.0004 19.8 0.0 0.00063 19.2 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX56965.1 - 0.0005 20.3 0.0 0.6 10.3 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 ORX56965.1 - 0.015 14.9 0.0 1 8.8 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B SRPRB PF09439.10 ORX56965.1 - 0.016 14.6 0.1 0.7 9.3 0.0 2.8 3 1 1 4 4 4 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ORX56965.1 - 0.045 14.1 0.1 0.17 12.3 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain EF-hand_8 PF13833.6 ORX56965.1 - 0.049 13.5 0.0 16 5.4 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 ORX56965.1 - 0.062 13.8 0.3 0.6 10.6 0.0 2.2 1 1 1 2 2 2 0 EF-hand domain pair AIG1 PF04548.16 ORX56965.1 - 0.073 12.4 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 AIG1 family AAA_28 PF13521.6 ORX56965.1 - 0.075 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX56965.1 - 0.084 12.9 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ras PF00071.22 ORX56965.1 - 0.095 12.3 0.1 12 5.4 0.0 2.3 2 0 0 2 2 2 0 Ras family TIP49 PF06068.13 ORX56965.1 - 0.14 11.3 0.1 1.4 8.0 0.0 2.4 3 0 0 3 3 3 0 TIP49 P-loop domain PduV-EutP PF10662.9 ORX56965.1 - 0.16 11.7 0.1 5.7 6.7 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation TRAPP PF04051.16 ORX56966.1 - 8e-47 158.6 0.0 9.4e-47 158.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component HIG_1_N PF04588.13 ORX56967.1 - 2.4e-19 69.3 1.3 3.8e-19 68.6 1.3 1.3 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Arrestin_N PF00339.29 ORX56968.1 - 1.1e-09 38.5 0.0 1.8e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain ORC6 PF05460.13 ORX56968.1 - 0.092 12.0 3.1 3.5 6.8 3.1 2.1 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) KTI12 PF08433.10 ORX56969.1 - 4.1e-90 301.9 0.0 4.6e-90 301.8 0.0 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 ORX56969.1 - 1.1e-08 35.4 0.0 1.9e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX56969.1 - 0.00022 21.8 0.0 0.0005 20.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX56969.1 - 0.0053 17.2 0.0 0.009 16.4 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ORX56969.1 - 0.024 15.0 0.0 0.07 13.5 0.0 2.0 1 1 0 1 1 1 0 RNA helicase DUF2075 PF09848.9 ORX56969.1 - 0.042 13.1 0.2 0.11 11.8 0.1 1.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ORX56969.1 - 0.042 14.1 0.0 0.1 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DNA_pol_B PF00136.21 ORX56969.1 - 0.05 12.3 0.0 0.068 11.9 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase family B AAA_14 PF13173.6 ORX56969.1 - 0.053 13.6 0.0 0.086 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain HAGH_C PF16123.5 ORX56970.1 - 3.3e-22 78.8 0.0 4.9e-22 78.2 0.0 1.2 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 ORX56970.1 - 5.4e-10 39.6 4.3 7.7e-08 32.6 4.3 2.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX56970.1 - 0.00029 20.4 0.2 0.0034 16.9 0.2 2.2 1 1 0 1 1 1 1 Beta-lactamase superfamily domain BORCS8 PF10167.9 ORX56971.1 - 1.9e-09 37.4 0.2 2.3e-09 37.2 0.2 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 Laminin_II PF06009.12 ORX56971.1 - 0.0096 15.9 0.3 0.017 15.1 0.3 1.6 1 1 0 1 1 1 1 Laminin Domain II DDE_Tnp_Tn3 PF01526.17 ORX56971.1 - 0.019 13.8 0.2 0.023 13.5 0.2 1.1 1 0 0 1 1 1 0 Tn3 transposase DDE domain 4HBT_2 PF13279.6 ORX56972.1 - 1.2e-12 48.4 0.1 1.7e-12 47.9 0.1 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl-ACP_TE PF01643.17 ORX56972.1 - 0.0041 16.4 0.1 0.006 15.9 0.1 1.2 1 0 0 1 1 1 1 Acyl-ACP thioesterase ATP-synt_ab PF00006.25 ORX56973.1 - 1.4e-68 230.8 0.0 1.9e-68 230.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX56973.1 - 1.5e-11 44.6 0.3 3.1e-11 43.6 0.3 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF3533 PF12051.8 ORX56973.1 - 0.15 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) CBF PF03914.17 ORX56974.1 - 5e-32 111.3 2.1 5e-32 111.3 2.1 3.1 2 1 0 2 2 2 1 CBF/Mak21 family DCB PF16213.5 ORX56974.1 - 0.021 14.5 0.6 0.049 13.3 0.6 1.7 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 GvpL_GvpF PF06386.11 ORX56974.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PcfK PF14058.6 ORX56974.1 - 0.18 12.1 6.5 0.076 13.3 2.9 2.2 2 0 0 2 2 2 0 PcfK-like protein WD40 PF00400.32 ORX56976.1 - 3.8e-25 87.7 10.7 2.2e-06 28.3 0.1 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX56976.1 - 4.5e-09 36.5 0.4 0.98 9.8 0.0 5.6 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX56976.1 - 0.00062 18.8 0.5 0.28 10.1 0.2 3.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX56976.1 - 0.0023 17.3 0.1 0.3 10.4 0.0 2.9 3 0 0 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 ORX56976.1 - 0.02 13.6 0.1 0.42 9.3 0.0 2.7 2 1 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 ORX56976.1 - 0.027 13.1 1.8 3.3 6.2 0.2 3.1 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Nup192 PF11894.8 ORX56977.1 - 1e-112 377.7 6.4 2.6e-112 376.3 6.5 1.4 1 1 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 MMADHC PF10229.9 ORX56978.1 - 5.4e-21 75.6 0.0 6.8e-21 75.2 0.0 1.1 1 0 0 1 1 1 1 Methylmalonic aciduria and homocystinuria type D protein VASt PF16016.5 ORX56979.1 - 2e-39 135.4 0.6 2e-39 135.4 0.6 2.1 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 ORX56979.1 - 5.2e-25 87.5 0.5 1.3e-24 86.3 0.0 1.9 2 0 0 2 2 2 1 GRAM domain PH PF00169.29 ORX56980.1 - 1.4e-08 35.1 0.0 0.00043 20.8 0.0 2.8 3 0 0 3 3 3 2 PH domain zf-C2H2_4 PF13894.6 ORX56983.1 - 2.4e-08 34.1 4.1 0.001 19.7 0.4 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 ORX56983.1 - 1.2e-06 28.8 1.5 0.00082 19.8 0.1 2.5 2 0 0 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 ORX56983.1 - 2e-06 27.7 4.7 0.01 15.8 0.6 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX56983.1 - 6.9e-06 26.3 2.7 1.6e-05 25.2 2.7 1.6 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 ORX56983.1 - 3e-05 24.2 8.0 0.014 15.8 0.2 3.4 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-MYST PF17772.1 ORX56983.1 - 6.4e-05 22.5 3.3 0.021 14.4 0.4 2.5 2 1 0 2 2 2 2 MYST family zinc finger domain zf-C2H2_3rep PF18868.1 ORX56983.1 - 0.00025 21.7 4.2 0.075 13.7 1.2 2.2 2 0 0 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_9 PF16293.5 ORX56983.1 - 0.00076 19.3 0.4 0.052 13.4 0.1 2.4 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) Zn-C2H2_12 PF18112.1 ORX56983.1 - 0.0032 17.9 0.6 0.0032 17.9 0.6 2.3 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 ORX56983.1 - 0.0034 17.6 1.9 0.13 12.6 0.4 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding DUF629 PF04780.12 ORX56983.1 - 0.0035 15.9 2.6 0.16 10.5 0.5 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF629) FOXP-CC PF16159.5 ORX56983.1 - 0.012 16.2 2.9 0.13 12.9 0.4 2.5 2 1 0 2 2 2 0 FOXP coiled-coil domain DUF3510 PF12022.8 ORX56983.1 - 0.035 14.5 2.2 0.42 11.0 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3510) zf-C2H2_jaz PF12171.8 ORX56983.1 - 0.042 14.1 7.5 0.24 11.7 0.2 3.2 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding OrsD PF12013.8 ORX56983.1 - 0.17 12.3 6.0 1.5 9.3 1.1 2.2 1 1 1 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D zf-AD PF07776.15 ORX56983.1 - 0.58 10.4 4.3 0.93 9.8 0.2 2.5 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) zf-H2C2_2 PF13465.6 ORX56983.1 - 2 9.0 6.1 4.3 7.9 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double domain rve PF00665.26 ORX56984.1 - 0.00013 22.1 0.0 0.00031 20.9 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 ORX56984.1 - 0.0066 16.2 0.0 0.013 15.3 0.0 1.7 1 1 0 1 1 1 1 Integrase core domain PAS_10 PF13596.6 ORX56984.1 - 0.021 15.4 0.5 0.032 14.8 0.5 1.3 1 0 0 1 1 1 0 PAS domain Chromo PF00385.24 ORX56985.1 - 2.9e-12 46.3 1.7 3.8e-12 45.9 1.7 1.1 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 ORX56985.1 - 0.03 14.2 0.2 0.036 13.9 0.2 1.2 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Pallilysin PF18663.1 ORX56986.1 - 0.058 13.4 0.1 2.2 8.3 0.2 2.1 2 0 0 2 2 2 0 Pallilysin beta barrel domain Bestrophin PF01062.21 ORX56988.1 - 3.1e-41 141.7 0.4 1.8e-22 80.1 0.0 2.1 2 0 0 2 2 2 2 Bestrophin, RFP-TM, chloride channel DUF4239 PF14023.6 ORX56988.1 - 0.1 12.3 0.2 0.21 11.3 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) SH3_2 PF07653.17 ORX56989.1 - 6e-11 41.9 0.0 1.7e-10 40.4 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 ORX56989.1 - 2.4e-10 39.8 0.0 4.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX56989.1 - 2.2e-08 33.8 0.0 4.7e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX56989.1 - 0.021 15.1 0.0 0.041 14.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain GTP_EFTU PF00009.27 ORX56990.1 - 1.3e-55 188.0 0.0 2.5e-55 187.1 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX56990.1 - 7.2e-42 142.2 0.0 1.5e-41 141.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX56990.1 - 1.7e-14 53.9 1.2 1.7e-14 53.9 1.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX56990.1 - 0.00066 19.8 0.1 0.014 15.5 0.1 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF4203 PF13886.6 ORX56991.1 - 5.7e-18 65.3 26.8 9e-18 64.7 26.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF373 PF04123.13 ORX56991.1 - 0.97 8.8 5.4 0.1 12.0 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF373) PWWP PF00855.17 ORX56992.1 - 2.5e-15 56.6 0.1 1.1e-14 54.6 0.0 2.0 2 0 0 2 2 2 1 PWWP domain AMP-binding PF00501.28 ORX56993.1 - 4.3e-94 315.5 0.0 5.4e-94 315.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme DUF5305 PF17231.2 ORX56994.1 - 0.002 17.6 0.0 0.0036 16.7 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Rax2 PF12768.7 ORX56994.1 - 0.026 14.0 0.1 0.039 13.4 0.1 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity EphA2_TM PF14575.6 ORX56994.1 - 0.077 13.9 0.0 0.15 13.0 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SKG6 PF08693.10 ORX56994.1 - 0.15 11.5 2.3 0.33 10.4 2.3 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain DAP10 PF07213.11 ORX56994.1 - 0.33 10.9 8.8 0.16 11.9 0.7 2.6 1 1 1 2 2 2 0 DAP10 membrane protein DUF1771 PF08590.10 ORX56995.1 - 2.4e-17 63.0 13.5 2.4e-17 63.0 13.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) Smr PF01713.21 ORX56995.1 - 8e-12 45.4 0.0 8e-12 45.4 0.0 2.4 2 1 0 2 2 2 1 Smr domain DUF962 PF06127.11 ORX56996.1 - 5.8e-24 84.0 1.1 9.6e-24 83.3 1.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) DUF3712 PF12505.8 ORX56998.1 - 3.2e-30 105.0 0.0 2.9e-16 59.9 0.0 3.4 3 0 0 3 3 3 2 Protein of unknown function (DUF3712) Nup88 PF10168.9 ORX57000.1 - 1.2e-33 116.0 4.4 4.1e-22 77.8 1.1 2.1 2 0 0 2 2 2 2 Nuclear pore component Nup54 PF13874.6 ORX57000.1 - 0.00067 19.8 7.5 0.00067 19.8 7.5 1.9 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 DUF948 PF06103.11 ORX57000.1 - 1.2 9.5 5.5 0.48 10.7 2.2 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Allexi_40kDa PF05549.11 ORX57000.1 - 7.1 6.0 10.5 27 4.2 5.2 2.7 2 1 1 3 3 3 0 Allexivirus 40kDa protein ING PF12998.7 ORX57000.1 - 7.8 7.1 8.6 0.26 11.9 2.0 2.0 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Methyltr_RsmB-F PF01189.17 ORX57001.1 - 4.7e-29 101.5 0.1 1.7e-18 67.0 0.0 2.4 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_25 PF13649.6 ORX57001.1 - 4.2e-06 27.4 0.1 6.4e-05 23.6 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX57001.1 - 0.00011 22.0 0.0 0.001 18.9 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX57001.1 - 0.0025 18.4 0.1 0.025 15.2 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain PCMT PF01135.19 ORX57001.1 - 0.047 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ORX57001.1 - 0.062 13.4 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 ORX57001.1 - 0.11 12.4 0.1 0.51 10.3 0.1 1.9 2 0 0 2 2 2 0 Methyltransferase domain MMR_HSR1 PF01926.23 ORX57002.1 - 1.3e-15 57.4 1.0 2.1e-14 53.5 0.0 2.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX57002.1 - 2.3e-09 37.4 0.4 0.00066 19.6 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX57002.1 - 3.9e-06 26.5 0.1 3.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B AIG1 PF04548.16 ORX57002.1 - 0.00096 18.5 0.4 0.0036 16.7 0.1 2.0 1 1 1 2 2 2 1 AIG1 family Dynamin_N PF00350.23 ORX57002.1 - 0.00098 19.2 7.4 0.015 15.3 0.1 3.8 3 1 1 4 4 4 1 Dynamin family cobW PF02492.19 ORX57002.1 - 0.0096 15.5 0.1 0.21 11.2 0.0 2.8 2 1 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ORX57002.1 - 0.15 12.6 0.5 6 7.4 0.0 3.0 3 0 0 3 3 3 0 AAA domain CDC45 PF02724.14 ORX57002.1 - 0.35 9.1 10.9 0.56 8.4 10.9 1.2 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 ORX57002.1 - 0.57 8.9 8.4 0.87 8.3 8.4 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pes-10 PF07149.11 ORX57002.1 - 4.5 6.2 10.4 7.1 5.6 10.4 1.3 1 0 0 1 1 1 0 Pes-10 Lon_C PF05362.13 ORX57003.1 - 1.1e-70 237.3 0.0 2.4e-70 236.2 0.0 1.6 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 ORX57003.1 - 4.3e-32 111.7 0.0 1.2e-31 110.2 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 ORX57003.1 - 7.8e-23 81.3 0.0 2.1e-22 80.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX57003.1 - 1.8e-06 28.0 0.0 4.4e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 ORX57003.1 - 3.9e-06 26.7 0.0 8.4e-06 25.6 0.0 1.6 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 ORX57003.1 - 4e-06 27.1 0.0 9.7e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX57003.1 - 1.1e-05 25.3 0.0 9.6e-05 22.2 0.0 2.6 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_PrkA PF08298.11 ORX57003.1 - 1.5e-05 24.1 0.0 2.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 PrkA AAA domain AAA_22 PF13401.6 ORX57003.1 - 0.0002 21.6 0.4 0.0036 17.6 0.1 2.9 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 ORX57003.1 - 0.00055 20.4 0.1 0.0031 17.9 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ORX57003.1 - 0.00062 20.3 0.3 0.026 15.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain GRP PF07172.11 ORX57003.1 - 0.0023 18.6 3.3 0.0075 16.9 3.3 1.8 1 0 0 1 1 1 1 Glycine rich protein family AAA_14 PF13173.6 ORX57003.1 - 0.0072 16.4 0.0 0.02 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 ORX57003.1 - 0.0079 16.3 0.0 0.31 11.2 0.0 2.6 2 0 0 2 2 2 1 Shikimate kinase AAA_3 PF07726.11 ORX57003.1 - 0.019 14.8 0.0 0.088 12.7 0.0 2.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ORX57003.1 - 0.023 14.6 1.9 0.29 11.0 0.0 3.0 3 1 1 4 4 3 0 NTPase AAA_30 PF13604.6 ORX57003.1 - 0.024 14.4 0.0 0.082 12.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain DNTTIP1_dimer PF18192.1 ORX57003.1 - 0.04 14.3 3.3 3.5 8.1 0.2 3.2 2 2 0 2 2 2 0 DNTTIP1 dimerisation domain RNA_helicase PF00910.22 ORX57003.1 - 0.049 14.0 0.0 0.18 12.2 0.0 2.0 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 ORX57003.1 - 0.081 12.8 0.1 0.23 11.4 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase IstB_IS21 PF01695.17 ORX57003.1 - 0.13 12.0 0.0 0.27 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 ORX57003.1 - 0.15 11.7 0.5 2 8.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ORX57003.1 - 0.17 11.9 0.0 0.38 10.7 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Phage_connect_1 PF05135.13 ORX57003.1 - 1.8 9.1 4.2 3.7 8.1 0.0 3.4 4 0 0 4 4 4 0 Phage gp6-like head-tail connector protein AA_permease_2 PF13520.6 ORX57004.1 - 7.8e-59 199.6 55.6 9.3e-59 199.3 55.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX57004.1 - 2.9e-29 102.0 43.1 4.2e-29 101.5 43.1 1.1 1 0 0 1 1 1 1 Amino acid permease ATP13 PF12921.7 ORX57004.1 - 0.14 12.0 1.5 0.78 9.6 0.0 2.5 3 0 0 3 3 3 0 Mitochondrial ATPase expression Mito_carr PF00153.27 ORX57005.1 - 9.9e-53 176.1 2.8 4.2e-22 77.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein BAG PF02179.16 ORX57006.1 - 0.005 17.2 4.7 0.1 13.0 4.7 2.2 1 1 0 1 1 1 1 BAG domain Phage_pRha PF09669.10 ORX57006.1 - 0.02 15.4 1.5 2.1 9.0 0.5 2.3 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) PSP1 PF04468.12 ORX57007.1 - 7.4e-34 115.9 3.7 1.1e-33 115.3 3.7 1.3 1 0 0 1 1 1 1 PSP1 C-terminal conserved region WD40 PF00400.32 ORX57008.1 - 1.7e-13 50.8 18.8 0.00054 20.7 0.3 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57008.1 - 6.1e-09 36.1 0.1 8.4e-05 22.8 0.0 4.5 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Usp PF00582.26 ORX57009.1 - 1.1e-22 81.1 0.0 1.8e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family Oxidored_nitro PF00148.19 ORX57009.1 - 0.015 14.0 0.0 0.022 13.5 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase GDI PF00996.18 ORX57010.1 - 3.6e-218 724.4 0.0 4.3e-218 724.1 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor RE_Bsp6I PF09504.10 ORX57010.1 - 0.091 12.4 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Bsp6I restriction endonuclease Mod_r PF07200.13 ORX57011.1 - 5.5e-39 133.6 10.9 7.5e-39 133.2 10.9 1.2 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein UEV PF05743.13 ORX57011.1 - 0.011 15.6 0.2 0.027 14.3 0.2 1.7 1 0 0 1 1 1 0 UEV domain DUF489 PF04356.12 ORX57011.1 - 0.019 15.0 0.8 0.031 14.3 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF489) CENP-F_leu_zip PF10473.9 ORX57011.1 - 0.035 14.1 4.6 0.063 13.3 4.6 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FliD_C PF07195.12 ORX57011.1 - 0.044 13.2 2.5 0.082 12.3 2.5 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus SMODS PF18144.1 ORX57011.1 - 0.055 13.6 0.5 0.26 11.4 0.3 2.1 1 1 1 2 2 2 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain MRP-S26 PF14943.6 ORX57011.1 - 0.055 13.4 5.8 0.087 12.7 5.8 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 TMF_DNA_bd PF12329.8 ORX57011.1 - 0.11 12.5 6.2 0.18 11.8 5.4 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding CENP-H PF05837.12 ORX57011.1 - 0.9 10.0 6.7 0.47 10.9 4.6 1.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Bap31_Bap29_C PF18035.1 ORX57011.1 - 1.4 8.9 6.1 1.1 9.3 2.7 2.2 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain LRR_4 PF12799.7 ORX57012.1 - 0.00097 19.5 2.8 21 5.7 0.2 5.2 2 2 3 6 6 6 1 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX57012.1 - 0.12 12.4 0.4 61 4.0 0.0 4.0 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 ORX57012.1 - 0.24 12.1 4.1 39 5.3 0.2 4.4 3 1 0 3 3 3 0 Leucine Rich Repeat WD40 PF00400.32 ORX57013.1 - 3.8e-40 135.1 28.8 1e-08 35.7 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ORX57013.1 - 1.5e-10 40.3 6.9 0.055 12.1 0.0 5.2 4 1 1 5 5 5 5 Nucleoporin Nup120/160 F-box-like PF12937.7 ORX57013.1 - 2.8e-07 30.3 0.9 5e-07 29.5 0.9 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 ORX57013.1 - 3.2e-07 30.5 1.8 0.056 13.8 0.0 4.3 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 ORX57013.1 - 4.6e-06 26.4 0.1 9.7e-06 25.3 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ORX57013.1 - 0.00012 21.9 0.0 0.00041 20.2 0.0 1.8 1 0 0 1 1 1 1 F-box WD40_like PF17005.5 ORX57013.1 - 0.00034 20.1 0.0 1.5 8.1 0.1 3.1 2 1 1 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 ORX57013.1 - 0.0018 17.1 0.7 0.3 9.8 0.0 3.1 2 2 1 3 3 3 1 Nup133 N terminal like eIF2A PF08662.11 ORX57013.1 - 0.0031 17.4 0.0 1.2 9.0 0.0 2.7 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A CDH PF02611.15 ORX57013.1 - 0.062 12.9 0.1 4.2 6.9 0.0 2.9 3 0 0 3 3 3 0 CDP-diacylglycerol pyrophosphatase DUF5046 PF16465.5 ORX57013.1 - 0.4 10.1 1.9 0.59 9.5 0.1 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5046) Hira PF07569.11 ORX57013.1 - 3.9 7.1 5.5 6 6.5 0.0 3.7 4 1 0 4 4 4 0 TUP1-like enhancer of split Amidohydro_1 PF01979.20 ORX57015.1 - 8.9e-72 242.3 2.9 1.3e-71 241.7 2.9 1.2 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 ORX57015.1 - 1.4e-52 177.1 2.2 3.7e-52 175.7 2.2 1.8 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 ORX57015.1 - 5.3e-39 132.2 0.1 1.1e-38 131.2 0.1 1.5 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 ORX57015.1 - 6e-18 65.0 0.0 1.6e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 Urease, gamma subunit Amidohydro_3 PF07969.11 ORX57015.1 - 1.5e-08 34.6 0.1 1.1e-07 31.7 0.0 2.3 3 0 0 3 3 3 1 Amidohydrolase family DUF1869 PF08956.10 ORX57017.1 - 0.023 14.6 0.2 0.043 13.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) Utp8 PF10395.9 ORX57018.1 - 3.2e-08 32.6 4.0 2.2e-07 29.8 4.0 2.2 1 1 0 1 1 1 1 Utp8 family Utp12 PF04003.12 ORX57018.1 - 0.0021 18.3 0.3 0.0068 16.7 0.0 2.1 2 0 0 2 2 2 1 Dip2/Utp12 Family Fasciclin PF02469.22 ORX57019.1 - 2.9e-30 105.1 4.1 4.8e-14 52.7 2.6 3.2 2 1 0 2 2 2 2 Fasciclin domain Fasciclin PF02469.22 ORX57020.1 - 7.6e-22 77.9 0.1 1.5e-10 41.4 0.0 2.4 2 0 0 2 2 2 2 Fasciclin domain DUF4124 PF13511.6 ORX57020.1 - 0.1 12.9 0.1 0.28 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4124) ECH_1 PF00378.20 ORX57021.1 - 1.4e-82 276.8 0.7 1.7e-82 276.5 0.7 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX57021.1 - 1.7e-33 116.5 0.7 3.9e-32 112.1 0.5 2.0 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 ORX57021.1 - 0.00043 20.3 0.3 0.058 13.3 0.0 2.4 2 0 0 2 2 2 2 Peptidase family S49 MaoC_dehydratas PF01575.19 ORX57022.1 - 0.017 14.7 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 MaoC like domain XPG_N PF00752.17 ORX57023.1 - 1.3e-26 93.0 0.0 2.4e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ORX57023.1 - 3.5e-24 85.0 0.2 6.4e-24 84.1 0.2 1.5 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ORX57023.1 - 6.5e-06 25.8 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 ORX57023.1 - 0.053 14.1 0.0 0.19 12.4 0.0 1.9 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold HemY_N PF07219.13 ORX57023.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 HemY protein N-terminus Tim17 PF02466.19 ORX57024.1 - 1.5e-13 51.1 0.0 3.8e-13 49.8 0.0 1.6 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family MARVEL PF01284.23 ORX57025.1 - 6e-11 42.6 6.4 8.1e-11 42.1 6.4 1.1 1 0 0 1 1 1 1 Membrane-associating domain SUR7 PF06687.12 ORX57025.1 - 0.028 14.1 8.1 0.4 10.3 8.1 2.0 1 1 0 1 1 1 0 SUR7/PalI family LRR19-TM PF15176.6 ORX57025.1 - 0.056 13.4 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DUF3397 PF11877.8 ORX57025.1 - 0.77 10.0 5.9 4.9 7.4 2.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3397) Lung_7-TM_R PF06814.13 ORX57026.1 - 7e-40 137.1 18.0 9.2e-40 136.7 18.0 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ORX57026.1 - 0.003 17.0 12.7 0.0047 16.4 11.7 1.7 1 1 1 2 2 2 1 Rhodopsin-like GPCR transmembrane domain DUF1640 PF07798.11 ORX57028.1 - 1.3e-47 162.1 9.1 1.4e-47 162.0 9.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) RasGAP_C PF03836.15 ORX57028.1 - 0.0012 19.0 7.4 0.025 14.7 0.1 2.3 2 1 0 2 2 2 1 RasGAP C-terminus Tmemb_cc2 PF10267.9 ORX57028.1 - 0.0055 15.9 9.3 0.0068 15.6 9.3 1.1 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein Golgin_A5 PF09787.9 ORX57028.1 - 0.01 15.4 12.4 0.014 14.9 12.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Spc7 PF08317.11 ORX57028.1 - 0.016 14.1 9.5 0.021 13.7 9.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Fungal_TACC PF12709.7 ORX57028.1 - 0.024 15.1 7.3 0.34 11.4 1.7 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins FAP206 PF12018.8 ORX57028.1 - 0.044 13.3 4.8 0.042 13.4 1.4 2.0 2 0 0 2 2 2 0 Domain of unknown function XhlA PF10779.9 ORX57028.1 - 0.11 12.7 8.5 0.15 12.3 0.2 2.7 2 1 0 2 2 2 0 Haemolysin XhlA Mt_ATP-synt_D PF05873.12 ORX57028.1 - 0.12 12.2 5.3 7.2 6.4 0.1 2.3 2 1 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF5082 PF16888.5 ORX57028.1 - 0.14 12.4 14.9 0.61 10.4 14.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Remorin_C PF03763.13 ORX57028.1 - 0.15 11.9 7.5 0.18 11.7 6.5 1.6 1 1 0 1 1 1 0 Remorin, C-terminal region KASH_CCD PF14662.6 ORX57028.1 - 0.16 11.8 14.4 0.26 11.1 13.7 1.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 ORX57028.1 - 0.16 12.2 6.0 3.4 8.0 1.3 2.6 2 1 0 2 2 2 0 Homeobox associated leucine zipper FapA PF03961.13 ORX57028.1 - 0.19 10.3 10.8 0.071 11.7 7.1 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF1451 PF07295.11 ORX57028.1 - 0.33 11.0 6.0 1.1 9.3 2.7 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain FlaC_arch PF05377.11 ORX57028.1 - 0.68 10.4 9.2 0.65 10.4 1.7 3.1 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) Lectin_N PF03954.14 ORX57028.1 - 0.78 9.5 7.2 4.9 6.9 0.1 2.9 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Bcr-Abl_Oligo PF09036.10 ORX57028.1 - 1.2 9.2 3.7 1.6 8.8 0.8 2.3 2 1 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF4140 PF13600.6 ORX57028.1 - 1.2 9.6 12.6 7.3 7.1 4.8 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) MbeB_N PF04837.12 ORX57028.1 - 1.5 9.1 10.8 0.55 10.6 1.0 3.4 2 2 1 3 3 3 0 MbeB-like, N-term conserved region Nas2_N PF18265.1 ORX57028.1 - 1.5 8.8 11.4 3.4 7.7 0.8 3.9 2 2 1 3 3 3 0 Nas2 N_terminal domain SlyX PF04102.12 ORX57028.1 - 1.6 9.4 12.5 0.36 11.5 0.5 3.8 3 1 1 4 4 4 0 SlyX DivIC PF04977.15 ORX57028.1 - 1.6 8.5 15.5 0.43 10.4 3.4 3.1 1 1 2 3 3 3 0 Septum formation initiator YabA PF06156.13 ORX57028.1 - 2 9.1 10.8 4.1 8.1 5.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA FlxA PF14282.6 ORX57028.1 - 2 8.4 12.9 3.9 7.5 0.8 2.5 2 1 0 2 2 2 0 FlxA-like protein bZIP_1 PF00170.21 ORX57028.1 - 2.3 8.4 8.1 8.8 6.5 1.2 2.5 2 1 0 2 2 2 0 bZIP transcription factor Vps51 PF08700.11 ORX57028.1 - 3.3 7.9 11.7 4.5 7.4 1.4 3.3 2 1 1 3 3 3 0 Vps51/Vps67 Ax_dynein_light PF10211.9 ORX57028.1 - 4 7.4 14.7 20 5.1 5.0 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain Baculo_PEP_C PF04513.12 ORX57028.1 - 4.2 7.4 8.9 6.7 6.7 3.4 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus APG6_N PF17675.1 ORX57028.1 - 7.4 7.1 13.2 6.5e+02 0.8 13.6 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region TMPIT PF07851.13 ORX57028.1 - 8 5.6 11.3 2.2 7.4 4.1 2.0 1 1 1 2 2 2 0 TMPIT-like protein Fzo_mitofusin PF04799.13 ORX57028.1 - 8.8 5.9 11.8 9.4 5.8 0.7 2.8 1 1 1 2 2 2 0 fzo-like conserved region DUF3425 PF11905.8 ORX57029.1 - 1e-13 51.3 0.4 3.5e-13 49.6 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 ORX57029.1 - 5.5e-05 23.2 11.7 0.00011 22.3 11.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor SHE3 PF17078.5 ORX57029.1 - 0.064 13.0 3.0 0.12 12.1 3.0 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF5094 PF17015.5 ORX57029.1 - 0.14 12.2 2.6 0.25 11.5 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) DUF4140 PF13600.6 ORX57029.1 - 0.88 10.1 3.1 2 8.9 3.1 1.6 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) ABC_tran_Xtn PF12848.7 ORX57029.1 - 9.5 6.3 11.0 4.4 7.4 7.5 2.1 2 0 0 2 2 2 0 ABC transporter Chlam_OMP6 PF03504.13 ORX57030.1 - 0.0059 16.9 0.0 0.01 16.1 0.0 1.4 1 0 0 1 1 1 1 Chlamydia cysteine-rich outer membrane protein 6 DUF3425 PF11905.8 ORX57031.1 - 3.9e-08 33.3 0.5 3.1e-07 30.4 0.5 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3425) DUF5094 PF17015.5 ORX57031.1 - 0.063 13.4 1.7 0.11 12.6 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) bZIP_2 PF07716.15 ORX57031.1 - 0.083 13.0 20.7 0.4 10.8 1.0 2.4 1 1 1 2 2 2 0 Basic region leucine zipper DUF2576 PF10845.8 ORX57031.1 - 0.18 11.4 0.4 0.39 10.4 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2576) bZIP_1 PF00170.21 ORX57031.1 - 0.61 10.2 23.0 0.2 11.8 18.7 2.3 2 1 0 2 2 2 0 bZIP transcription factor Syntaxin-18_N PF10496.9 ORX57031.1 - 2.3 8.5 5.8 10 6.5 2.1 2.5 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Cep57_CLD_2 PF14197.6 ORX57031.1 - 2.4 8.3 8.1 0.53 10.4 4.7 1.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 CVNH PF08881.10 ORX57032.1 - 0.02 15.6 0.1 0.032 14.9 0.1 1.4 1 0 0 1 1 1 0 CVNH domain GATA PF00320.27 ORX57032.1 - 0.036 13.7 8.8 0.036 13.7 8.8 3.1 2 1 0 2 2 2 0 GATA zinc finger zf-ribbon_3 PF13248.6 ORX57032.1 - 3.8 7.1 9.7 19 4.8 0.2 2.7 2 0 0 2 2 2 0 zinc-ribbon domain SASA PF03629.18 ORX57034.1 - 3.4e-27 95.6 0.0 4.7e-27 95.1 0.0 1.2 1 0 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase G-alpha PF00503.20 ORX57035.1 - 1.6e-110 369.6 0.3 2.2e-110 369.2 0.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX57035.1 - 2.6e-13 49.8 0.7 1.7e-08 34.1 0.1 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX57035.1 - 0.001 18.4 4.5 0.034 13.5 0.2 3.0 2 2 0 2 2 2 2 Gtr1/RagA G protein conserved region FtsK_SpoIIIE PF01580.18 ORX57035.1 - 0.0094 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family Roc PF08477.13 ORX57035.1 - 0.024 14.9 0.1 1.6 8.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ORX57035.1 - 0.039 13.7 0.1 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sugar_tr PF00083.24 ORX57036.1 - 1.2e-119 400.2 30.8 1.3e-119 400.0 30.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX57036.1 - 3.7e-23 82.0 42.7 3.1e-20 72.4 33.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily TPR_19 PF14559.6 ORX57036.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat DDE_3 PF13358.6 ORX57037.1 - 8.8e-05 22.3 0.2 0.00012 21.9 0.2 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease GST_N_3 PF13417.6 ORX57038.1 - 1.2e-12 48.1 0.0 5e-12 46.1 0.0 2.0 3 0 0 3 3 3 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX57038.1 - 1.4e-08 34.9 0.0 3.1e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX57038.1 - 4.6e-05 23.7 0.0 8.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX57038.1 - 0.00043 20.4 0.0 0.001 19.2 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX57038.1 - 0.0055 16.7 0.1 0.011 15.8 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Glutaredoxin2_C PF04399.13 ORX57038.1 - 0.02 14.7 0.0 0.034 14.0 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain GST_C_3 PF14497.6 ORX57038.1 - 0.064 13.5 0.1 0.3 11.3 0.1 2.2 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Sugar_tr PF00083.24 ORX57040.1 - 2.2e-111 372.9 25.0 3e-111 372.5 25.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX57040.1 - 1.6e-24 86.5 33.9 1.5e-17 63.5 12.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily GST_N_3 PF13417.6 ORX57041.1 - 1.7e-12 47.6 0.0 3.6e-12 46.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX57041.1 - 1.4e-10 41.3 0.0 2.9e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX57041.1 - 0.028 14.7 0.0 0.056 13.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Glutaredoxin2_C PF04399.13 ORX57041.1 - 0.053 13.4 0.0 0.092 12.6 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain RhoGAP PF00620.27 ORX57042.1 - 3.5e-35 121.1 0.0 5e-35 120.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain BRO1 PF03097.18 ORX57043.1 - 6.2e-131 436.8 2.6 6.2e-131 436.8 2.6 2.1 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 ORX57043.1 - 2.1e-45 155.3 17.5 5e-45 154.0 17.5 1.7 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV NGF PF00243.18 ORX57043.1 - 0.081 13.2 0.1 0.26 11.5 0.1 1.9 1 0 0 1 1 1 0 Nerve growth factor family GldM_N PF12081.8 ORX57043.1 - 0.23 11.5 4.8 1 9.4 4.0 2.6 1 1 0 1 1 1 0 GldM N-terminal domain Caldesmon PF02029.15 ORX57043.1 - 2.1 7.0 12.0 3.8 6.1 12.0 1.4 1 0 0 1 1 1 0 Caldesmon G-alpha PF00503.20 ORX57044.1 - 3.3e-122 408.1 5.1 3.8e-122 407.9 5.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX57044.1 - 6.3e-16 58.3 4.2 6.9e-12 45.2 0.4 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX57044.1 - 5.2e-05 22.7 3.5 0.0027 17.1 0.1 2.6 2 1 1 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX57044.1 - 0.0041 17.3 0.2 1.9 8.7 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 ORX57044.1 - 0.019 14.7 0.1 0.019 14.7 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain zf-CHC2 PF01807.20 ORX57044.1 - 0.025 14.4 0.0 0.097 12.5 0.0 2.0 2 0 0 2 2 2 0 CHC2 zinc finger AAA_29 PF13555.6 ORX57044.1 - 0.034 13.9 0.1 0.072 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ORX57044.1 - 0.07 12.5 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMR_HSR1 PF01926.23 ORX57044.1 - 0.081 13.0 0.0 4.4 7.4 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase Chs7 PF12271.8 ORX57045.1 - 3.4e-115 384.3 19.7 4.2e-115 384.1 19.7 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone HycH PF07450.11 ORX57046.1 - 0.077 13.4 0.0 0.39 11.1 0.0 2.1 2 0 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH ArfGap PF01412.18 ORX57047.1 - 2.9e-29 101.5 0.1 6.5e-29 100.4 0.1 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DNA_Packaging PF11053.8 ORX57047.1 - 0.11 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Septin PF00735.18 ORX57049.1 - 2.1e-121 404.6 0.1 2.1e-121 404.6 0.1 1.5 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 ORX57049.1 - 3.9e-09 36.6 0.3 1.5e-08 34.7 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX57049.1 - 3.6e-06 27.0 6.6 2.9e-05 24.0 0.1 2.9 3 0 0 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ORX57049.1 - 0.00017 21.2 4.5 0.0049 16.4 0.0 3.2 2 2 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ORX57049.1 - 0.00027 21.5 3.1 0.0045 17.5 0.0 2.6 2 1 0 2 2 2 1 ABC transporter AIG1 PF04548.16 ORX57049.1 - 0.00084 18.7 0.0 0.00084 18.7 0.0 2.1 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 ORX57049.1 - 0.0016 18.0 0.5 0.0056 16.3 0.0 2.2 2 0 0 2 2 2 1 Ras family AAA_16 PF13191.6 ORX57049.1 - 0.0018 18.7 0.2 0.0061 16.9 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX57049.1 - 0.0025 18.1 0.9 0.0064 16.8 0.0 2.3 2 2 0 2 2 2 1 AAA domain Roc PF08477.13 ORX57049.1 - 0.005 17.0 0.0 0.013 15.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ORX57049.1 - 0.028 14.2 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ORX57049.1 - 0.052 13.3 0.1 0.14 11.8 0.0 1.9 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX57049.1 - 0.1 13.0 0.4 0.85 10.0 0.0 2.4 2 1 0 2 2 2 0 RNA helicase Dynamin_N PF00350.23 ORX57049.1 - 0.11 12.5 9.2 0.37 10.8 0.1 3.4 2 2 1 3 3 2 0 Dynamin family Exonuc_VII_L PF02601.15 ORX57049.1 - 0.19 11.2 7.8 0.32 10.5 7.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Caskin-tail PF16632.5 ORX57049.1 - 0.24 11.9 1.8 1.2 9.6 0.0 2.6 2 0 0 2 2 2 0 C-terminal region of Caskin DUF87 PF01935.17 ORX57049.1 - 0.25 11.4 2.6 3.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Helicase HerA, central domain Atg14 PF10186.9 ORX57049.1 - 0.51 9.4 10.3 0.82 8.7 10.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_23 PF13476.6 ORX57049.1 - 0.84 10.1 10.8 3.6 8.0 6.3 2.4 2 1 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 ORX57049.1 - 1.4 8.6 6.2 14 5.4 0.1 3.5 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein DUF4776 PF16003.5 ORX57049.1 - 1.8 7.4 11.2 2.4 7.1 11.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Strep_SA_rep PF06696.11 ORX57049.1 - 2 8.5 9.7 0.46 10.5 3.1 3.0 1 1 1 2 2 2 0 Streptococcal surface antigen repeat DUF3987 PF13148.6 ORX57049.1 - 6.6 5.6 11.3 11 4.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) TIM21 PF08294.11 ORX57050.1 - 7.7e-34 116.6 0.0 9.7e-34 116.3 0.0 1.1 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 ORX57050.1 - 2.1e-07 30.7 0.0 6.1e-07 29.2 0.0 1.8 1 1 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Rax2 PF12768.7 ORX57050.1 - 0.027 13.9 0.0 0.039 13.4 0.0 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity P16-Arc PF04699.14 ORX57051.1 - 3.8e-27 95.6 4.0 5.5e-22 78.9 0.5 2.0 1 1 1 2 2 2 2 ARP2/3 complex 16 kDa subunit (p16-Arc) Hexokinase_2 PF03727.16 ORX57052.1 - 2.6e-87 292.2 0.0 3.7e-87 291.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX57052.1 - 5.1e-74 248.5 0.0 7.2e-74 248.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Lin-8 PF03353.15 ORX57053.1 - 0.5 9.9 5.5 0.88 9.1 5.5 1.4 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist MEA1 PF06910.11 ORX57053.1 - 3.9 8.1 11.0 3.7 8.2 5.7 2.6 1 1 1 2 2 2 0 Male enhanced antigen 1 (MEA1) Ribosomal_S24e PF01282.19 ORX57054.1 - 8e-35 118.6 0.0 1.4e-34 117.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Pkinase PF00069.25 ORX57055.1 - 3e-63 213.7 0.0 5.2e-63 212.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX57055.1 - 1.8e-33 115.9 0.0 3.2e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ORX57055.1 - 2.7e-15 56.0 35.0 1.2e-07 31.4 13.7 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 ORX57055.1 - 2.7e-07 31.2 0.9 2.7e-07 31.2 0.9 2.8 2 0 0 2 2 2 1 Protein kinase C terminal domain HR1 PF02185.16 ORX57055.1 - 8.6e-05 22.6 12.2 0.0081 16.3 1.4 2.7 2 0 0 2 2 2 2 Hr1 repeat Kinase-like PF14531.6 ORX57055.1 - 0.0016 17.8 0.1 0.063 12.6 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX57055.1 - 0.016 14.0 0.0 0.038 12.8 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ORX57055.1 - 0.017 14.1 0.4 0.035 13.1 0.4 1.5 1 0 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 ORX57055.1 - 0.024 14.3 0.3 8.3 6.0 0.0 2.6 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 SlyX PF04102.12 ORX57055.1 - 0.15 12.7 1.0 0.49 11.1 0.6 2.1 1 1 0 1 1 1 0 SlyX Peptidase_M49 PF03571.15 ORX57056.1 - 2e-224 746.1 0.0 2.7e-224 745.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M49 SAP PF02037.27 ORX57057.1 - 8e-12 44.6 0.7 2.1e-11 43.3 0.7 1.8 2 0 0 2 2 2 1 SAP domain HicB_lk_antitox PF15919.5 ORX57057.1 - 0.0024 18.0 0.4 0.047 13.8 0.0 2.3 1 1 1 2 2 2 1 HicB_like antitoxin of bacterial toxin-antitoxin system Orthopox_F14 PF06076.12 ORX57057.1 - 0.025 14.9 0.3 0.04 14.2 0.3 1.3 1 0 0 1 1 1 0 Orthopoxvirus F14 protein EF-1_beta_acid PF10587.9 ORX57057.1 - 0.069 13.6 4.7 2.8 8.5 0.9 3.7 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Tho1_MOS11_C PF18592.1 ORX57057.1 - 6.5 6.7 18.6 0.52 10.1 2.5 3.5 3 2 1 4 4 4 0 Tho1/MOS11 C-terminal domain Nup192 PF11894.8 ORX57058.1 - 9.1e-207 689.4 0.3 6.5e-118 394.9 0.0 2.5 2 1 0 2 2 2 2 Nuclear pore complex scaffold, nucleoporins 186/192/205 HTH_32 PF13565.6 ORX57059.1 - 4e-05 24.1 0.0 6.1e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Homeodomain-like domain DUF3254 PF11630.8 ORX57059.1 - 0.11 12.6 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3254) HTH_28 PF13518.6 ORX57059.1 - 0.16 12.1 0.4 0.27 11.4 0.4 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 ORX57059.1 - 0.16 11.8 0.3 0.29 11.0 0.3 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Ribosomal_S6e PF01092.19 ORX57061.1 - 1.7e-61 205.7 1.2 3.9e-61 204.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e UPF0086 PF01868.16 ORX57062.1 - 3.2e-27 94.3 0.0 4.6e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function UPF0086 DUF2937 PF11157.8 ORX57062.1 - 0.024 14.4 0.0 0.037 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) DFRP_C PF16543.5 ORX57063.1 - 2.9e-27 95.0 3.6 2.9e-27 95.0 3.6 4.2 3 2 0 4 4 4 1 DRG Family Regulatory Proteins, Tma46 Torus PF16131.5 ORX57063.1 - 4.1e-05 24.2 21.1 0.44 11.3 15.3 4.4 3 1 0 3 3 3 2 Torus domain zf-CCCH PF00642.24 ORX57063.1 - 4.3e-05 23.3 0.7 4.3e-05 23.3 0.7 2.9 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX57063.1 - 0.00014 21.8 6.4 0.00014 21.8 6.4 3.2 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_4 PF18044.1 ORX57063.1 - 0.00021 21.0 11.0 0.0062 16.3 2.4 3.3 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX57063.1 - 0.13 12.8 13.5 0.07 13.6 5.4 2.8 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF3006 PF11213.8 ORX57063.1 - 2.4 8.4 13.9 0.23 11.7 0.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3006) Cellulase PF00150.18 ORX57064.1 - 9.9e-17 61.3 0.2 4.1e-13 49.4 0.0 2.5 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 ORX57064.1 - 1.1e-15 57.9 0.2 2.2e-15 56.9 0.2 1.6 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Glyco_hydro_35 PF01301.19 ORX57064.1 - 0.0013 18.5 0.0 0.0025 17.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 PCI PF01399.27 ORX57065.1 - 7.8e-10 39.2 0.7 5e-09 36.6 0.1 2.9 2 0 0 2 2 2 1 PCI domain DUF423 PF04241.15 ORX57066.1 - 3.6e-21 75.2 0.1 4.7e-21 74.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF423) Intg_mem_TP0381 PF09529.10 ORX57066.1 - 0.039 13.5 0.0 0.045 13.3 0.0 1.0 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) RF-1 PF00472.20 ORX57067.1 - 3.1e-17 62.6 0.2 3.5e-17 62.4 0.2 1.1 1 0 0 1 1 1 1 RF-1 domain RRM_1 PF00076.22 ORX57069.1 - 2.6e-85 280.2 5.1 2.2e-22 78.6 0.3 4.2 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX57069.1 - 1e-27 96.1 0.6 5.5e-27 93.7 0.4 2.3 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ORX57069.1 - 1.4e-14 53.8 0.1 0.018 14.6 0.1 4.2 1 1 3 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX57069.1 - 4e-07 30.1 0.2 0.25 11.5 0.0 4.8 4 1 0 4 4 4 2 RNA recognition motif Nup35_RRM_2 PF14605.6 ORX57069.1 - 2.5e-05 24.2 2.5 2.7 8.1 0.0 4.4 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 ORX57069.1 - 0.0013 18.4 2.6 3.7 7.3 0.2 3.5 3 0 0 3 3 3 2 Ribonuclease B OB domain RRM_3 PF08777.11 ORX57069.1 - 0.0034 17.4 5.8 6.2 6.9 0.2 4.0 4 0 0 4 4 4 2 RNA binding motif RRM_occluded PF16842.5 ORX57069.1 - 0.0059 16.4 0.0 0.76 9.7 0.0 2.7 3 0 0 3 3 3 1 Occluded RNA-recognition motif CbiG_mid PF11761.8 ORX57069.1 - 0.012 15.7 0.0 10 6.3 0.0 3.3 2 1 1 3 3 3 0 Cobalamin biosynthesis central region RE_Eco29kI PF09517.10 ORX57069.1 - 0.075 12.6 2.0 3.9 7.1 0.1 3.1 3 0 0 3 3 3 0 Eco29kI restriction endonuclease YflT PF11181.8 ORX57069.1 - 0.15 12.6 4.3 4.2 7.9 0.7 3.0 3 0 0 3 3 3 0 Heat induced stress protein YflT TauD PF02668.16 ORX57069.1 - 0.18 11.6 1.6 2.4 7.9 0.0 2.9 2 1 1 3 3 3 0 Taurine catabolism dioxygenase TauD, TfdA family Asp PF00026.23 ORX57070.1 - 2.2e-90 303.3 5.3 2.6e-90 303.0 5.3 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX57070.1 - 4.3e-15 56.4 5.1 1.3e-10 41.8 0.4 2.6 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX57070.1 - 0.00028 21.4 0.6 0.069 13.8 0.1 3.1 2 2 1 3 3 3 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX57070.1 - 0.00044 20.8 0.1 0.25 11.9 0.0 2.9 2 2 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 ORX57070.1 - 0.002 17.9 0.0 0.012 15.4 0.0 2.3 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal CG-1 PF03859.16 ORX57070.1 - 0.06 13.1 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 CG-1 domain DUF3145 PF11343.8 ORX57070.1 - 0.15 11.6 0.0 0.3 10.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) Rft-1 PF04506.13 ORX57072.1 - 1.3e-143 479.4 20.0 1.5e-143 479.2 20.0 1.0 1 0 0 1 1 1 1 Rft protein FH2 PF02181.23 ORX57073.1 - 5.1e-84 282.5 9.5 5.1e-84 282.5 9.5 2.3 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ORX57073.1 - 9.3e-49 165.5 0.0 2.4e-48 164.2 0.0 1.7 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX57073.1 - 3.8e-46 157.2 2.6 7.4e-45 153.0 0.4 2.8 2 0 0 2 2 2 1 Diaphanous FH3 Domain PTPS PF01242.19 ORX57073.1 - 0.13 12.2 0.6 2.7 8.0 0.2 2.8 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase DUF4250 PF14056.6 ORX57073.1 - 0.18 11.8 5.6 1.9 8.5 0.2 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4250) DNA_pack_N PF02500.15 ORX57073.1 - 0.18 11.6 1.5 0.61 9.9 0.5 2.2 1 1 0 2 2 2 0 Probable DNA packing protein, N-terminus DUF1664 PF07889.12 ORX57073.1 - 0.54 10.3 3.4 7 6.7 1.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) F-box-like PF12937.7 ORX57074.1 - 1.3e-06 28.1 0.5 1.3e-06 28.1 0.5 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX57074.1 - 0.00022 21.0 1.3 0.00046 20.0 0.0 2.2 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 ORX57075.1 - 8.3 7.0 8.3 37 4.9 0.1 4.3 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ORX57076.1 - 3.4e-08 33.2 1.3 1.3e-07 31.4 1.3 2.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX57076.1 - 0.00095 19.0 0.4 0.0029 17.4 0.4 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX57077.1 - 0.041 13.8 2.7 0.088 12.7 2.7 1.7 1 0 0 1 1 1 0 F-box-like PTN_MK_C PF01091.18 ORX57078.1 - 0.041 14.3 0.5 0.054 13.9 0.5 1.1 1 0 0 1 1 1 0 PTN/MK heparin-binding protein family, C-terminal domain zf-C2H2_4 PF13894.6 ORX57079.1 - 9e-05 23.0 10.6 0.056 14.3 0.5 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX57079.1 - 0.00019 21.7 3.3 0.00042 20.6 3.3 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ORX57079.1 - 0.0081 16.8 1.6 0.53 11.0 0.2 2.4 1 1 1 2 2 2 1 Zinc finger C2H2-type, 3 repeats Methyltransf_31 PF13847.6 ORX57079.1 - 0.024 14.5 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain zf-C2H2_6 PF13912.6 ORX57079.1 - 0.046 13.7 1.1 0.16 12.0 1.1 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 ORX57079.1 - 0.049 13.4 3.2 3.4 7.5 0.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Met_synt_B12 PF02965.17 ORX57359.1 - 0.27 10.7 0.0 0.38 10.2 0.0 1.1 1 0 0 1 1 1 0 Vitamin B12 dependent methionine synthase, activation domain DUF3846 PF12957.7 ORX57361.1 - 4.3e-11 43.0 0.1 1 9.7 0.0 6.1 3 1 3 6 6 6 4 Domain of unknown function (DUF3846) DsbG_N PF18257.1 ORX57361.1 - 0.00026 21.1 0.0 17 5.6 0.0 4.6 5 0 0 5 5 5 2 Disulfide isomerase DsbG N-terminal DUF3557 PF12078.8 ORX57361.1 - 0.2 11.6 0.0 2.8e+02 1.4 0.0 5.3 9 0 0 9 9 9 0 Domain of unknown function (DUF3557) Transferase PF02458.15 ORX57363.1 - 2.2e-54 184.8 0.0 2.9e-54 184.4 0.0 1.0 1 0 0 1 1 1 1 Transferase family Lipase_GDSL_2 PF13472.6 ORX57364.1 - 1.4e-26 94.0 0.0 2e-26 93.5 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX57364.1 - 2.6e-21 76.5 0.0 3.8e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase GAT PF03127.14 ORX57365.1 - 1.2e-05 25.5 1.3 3.1e-05 24.2 0.9 1.9 1 1 0 1 1 1 1 GAT domain VHS PF00790.19 ORX57365.1 - 0.0021 17.9 0.0 0.085 12.7 0.0 2.2 2 0 0 2 2 2 1 VHS domain DMT_YdcZ PF04657.13 ORX57366.1 - 4.9e-31 107.9 11.7 6.4e-31 107.5 11.7 1.1 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ Oxidored_q3 PF00499.20 ORX57366.1 - 0.027 14.2 5.7 0.054 13.2 5.6 1.7 1 1 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Peptidase_U4 PF03419.13 ORX57366.1 - 1.5 8.0 10.2 0.1 11.9 4.0 2.0 1 1 1 2 2 2 0 Sporulation factor SpoIIGA GATA PF00320.27 ORX57367.1 - 1.3e-16 59.9 4.4 2.7e-16 58.9 4.4 1.6 1 0 0 1 1 1 1 GATA zinc finger CAF20 PF17052.5 ORX57367.1 - 0.0028 17.8 2.0 0.03 14.5 1.5 2.0 1 1 1 2 2 2 2 Cap associated factor Rep_fac_C PF08542.11 ORX57368.1 - 1.3e-21 76.8 0.2 5.1e-21 74.9 0.1 2.1 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA PF00004.29 ORX57368.1 - 1.5e-16 61.0 0.0 2.6e-16 60.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ORX57368.1 - 1.2e-15 57.7 0.1 1e-10 41.7 0.1 2.3 1 1 1 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 ORX57368.1 - 1.2e-09 38.3 0.1 2.4e-06 27.6 0.0 2.3 1 1 0 2 2 2 2 Rad17 P-loop domain AAA_assoc_2 PF16193.5 ORX57368.1 - 4.1e-06 27.0 0.0 1e-05 25.8 0.0 1.7 1 0 0 1 1 1 1 AAA C-terminal domain RuvB_N PF05496.12 ORX57368.1 - 1e-05 25.3 0.0 2.1e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 ORX57368.1 - 1.4e-05 25.0 0.0 3.5e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX57368.1 - 2.8e-05 24.6 0.0 5.3e-05 23.7 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 ORX57368.1 - 3.2e-05 23.2 0.0 4.9e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ORX57368.1 - 6.6e-05 23.0 0.0 0.00013 22.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ORX57368.1 - 0.0001 22.2 0.0 0.00016 21.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 ORX57368.1 - 0.00013 21.5 0.1 0.11 12.0 0.0 2.4 1 1 1 2 2 2 2 Bacterial TniB protein ResIII PF04851.15 ORX57368.1 - 0.00061 19.8 0.1 0.2 11.7 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX57368.1 - 0.0024 18.1 1.1 0.73 10.1 0.1 3.0 2 1 1 3 3 3 1 AAA domain AAA_19 PF13245.6 ORX57368.1 - 0.0024 18.2 0.1 0.0091 16.3 0.1 1.9 1 1 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 ORX57368.1 - 0.0028 17.4 0.2 0.0051 16.6 0.2 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_7 PF12775.7 ORX57368.1 - 0.003 17.1 0.0 0.0064 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 ORX57368.1 - 0.004 16.9 0.0 0.011 15.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX57368.1 - 0.015 15.0 0.0 0.044 13.5 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 ORX57368.1 - 0.032 14.2 1.5 0.15 12.1 0.1 2.6 3 1 0 3 3 1 0 AAA domain (dynein-related subfamily) MCM PF00493.23 ORX57368.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Mg_chelatase PF01078.21 ORX57368.1 - 0.041 13.3 0.0 0.44 9.9 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DEAD PF00270.29 ORX57368.1 - 0.047 13.5 0.3 0.24 11.2 0.3 2.0 1 1 0 1 1 1 0 DEAD/DEAH box helicase PhoH PF02562.16 ORX57368.1 - 0.056 12.9 0.5 4.7 6.6 0.0 2.4 1 1 0 2 2 2 0 PhoH-like protein AAA_18 PF13238.6 ORX57368.1 - 0.061 13.9 0.1 0.15 12.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ORX57368.1 - 0.067 12.2 0.1 0.16 11.0 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein SNF2_N PF00176.23 ORX57368.1 - 0.071 11.8 0.2 0.16 10.7 0.0 1.6 2 0 0 2 2 2 0 SNF2 family N-terminal domain AAA_3 PF07726.11 ORX57368.1 - 0.075 12.9 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF4359 PF14271.6 ORX57368.1 - 0.079 13.7 1.3 0.17 12.6 0.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4359) Thioredoxin_6 PF13848.6 ORX57368.1 - 0.16 11.9 0.2 19 5.1 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain AAA_25 PF13481.6 ORX57368.1 - 0.31 10.6 0.8 5.6 6.5 0.1 2.7 2 1 1 3 3 3 0 AAA domain Tetraspanin PF00335.20 ORX57369.1 - 0.0033 17.2 2.7 0.0033 17.2 2.7 2.5 1 1 1 2 2 2 2 Tetraspanin family Atthog PF18800.1 ORX57371.1 - 0.049 13.5 0.1 0.093 12.6 0.1 1.4 1 0 0 1 1 1 0 Attenuator of Hedgehog OrfB_Zn_ribbon PF07282.11 ORX57371.1 - 0.1 12.6 3.5 0.13 12.2 0.3 2.4 2 0 0 2 2 2 0 Putative transposase DNA-binding domain TGF_beta_GS PF08515.12 ORX57375.1 - 0.78 9.3 3.6 1.1 8.8 1.2 2.1 2 0 0 2 2 2 0 Transforming growth factor beta type I GS-motif MatE PF01554.18 ORX57376.1 - 8e-47 158.9 19.4 8.7e-29 100.3 7.8 3.1 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 ORX57376.1 - 1.5e-06 28.4 1.4 1.5e-06 28.4 1.4 4.1 4 1 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain DUF3624 PF12292.8 ORX57376.1 - 0.11 12.9 6.4 1 9.8 0.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) MurJ PF03023.14 ORX57376.1 - 2.2 6.8 26.8 0.011 14.4 9.3 3.9 3 2 0 3 3 3 0 Lipid II flippase MurJ SNARE_assoc PF09335.11 ORX57377.1 - 1.4e-13 51.3 2.7 1.4e-13 51.3 2.7 2.7 2 1 1 3 3 3 1 SNARE associated Golgi protein DUF4381 PF14316.6 ORX57377.1 - 0.22 11.8 0.8 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) DUF4307 PF14155.6 ORX57377.1 - 0.25 11.2 1.2 9 6.2 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4307) NUDIX PF00293.28 ORX57379.1 - 6.1e-11 42.5 0.1 6.9e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain Cir_N PF10197.9 ORX57380.1 - 1.5e-13 50.7 12.0 1.5e-13 50.7 12.0 2.6 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 ORX57380.1 - 1.1e-10 42.3 0.5 1.1e-10 42.3 0.5 2.1 1 1 1 2 2 2 1 Pre-mRNA splicing factor DASH_Spc34 PF08657.10 ORX57380.1 - 0.047 13.5 5.0 0.067 13.0 5.0 1.2 1 0 0 1 1 1 0 DASH complex subunit Spc34 Mito_carr PF00153.27 ORX57381.1 - 4.1e-63 209.3 2.9 1.7e-21 76.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_60s PF00428.19 ORX57382.1 - 4e-26 91.4 11.3 4.6e-26 91.2 11.3 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 ORX57382.1 - 0.52 11.0 4.4 0.7 10.5 4.4 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Med26 PF08711.11 ORX57383.1 - 1.6e-13 50.4 1.3 2.4e-13 49.9 0.0 2.0 2 0 0 2 2 2 1 TFIIS helical bundle-like domain Catalase PF00199.19 ORX57384.1 - 1.6e-200 666.1 2.1 2.1e-200 665.7 2.1 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ORX57384.1 - 4.7e-23 81.2 0.1 1.1e-22 80.0 0.1 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive WD40 PF00400.32 ORX57385.1 - 7e-41 137.5 24.4 1.3e-06 29.0 0.3 7.9 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57385.1 - 1e-08 35.4 1.8 0.61 10.4 0.0 5.8 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ORX57385.1 - 2.5e-08 33.7 1.4 2.5e-08 33.7 1.4 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX57385.1 - 4.3e-08 32.8 0.6 9.1e-08 31.8 0.6 1.5 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ORX57385.1 - 6.5e-05 21.8 3.7 2 7.0 0.0 5.1 3 2 2 6 6 6 2 Nucleoporin Nup120/160 F-box_4 PF15966.5 ORX57385.1 - 0.00025 20.9 0.0 0.0006 19.7 0.0 1.6 1 0 0 1 1 1 1 F-box PQQ_2 PF13360.6 ORX57385.1 - 0.00078 19.1 0.5 0.004 16.8 0.2 2.0 2 0 0 2 2 2 1 PQQ-like domain WD40_like PF17005.5 ORX57385.1 - 0.0045 16.3 0.0 0.45 9.8 0.0 2.2 2 0 0 2 2 2 1 WD40-like domain PALB2_WD40 PF16756.5 ORX57385.1 - 0.017 14.1 1.4 9.5 5.0 0.0 4.0 3 2 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain STE PF02200.16 ORX57385.1 - 0.038 14.4 0.1 0.93 9.9 0.0 2.5 3 0 0 3 3 2 0 STE like transcription factor Nucleoporin_N PF08801.11 ORX57385.1 - 0.077 11.7 0.0 3 6.5 0.0 2.7 2 1 1 3 3 3 0 Nup133 N terminal like Vps5 PF09325.10 ORX57386.1 - 6.1e-07 29.2 4.2 9.8e-07 28.5 4.2 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 ORX57386.1 - 0.00045 20.2 1.2 0.0021 18.0 0.0 2.6 3 1 0 3 3 3 1 PX domain GST_N_4 PF17172.4 ORX57386.1 - 0.019 15.7 0.2 0.066 14.0 0.0 2.0 2 1 0 2 2 2 0 Glutathione S-transferase N-terminal domain Pkinase PF00069.25 ORX57387.1 - 4.8e-60 203.2 0.0 6e-60 202.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX57387.1 - 7e-37 127.1 0.0 8.2e-37 126.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX57387.1 - 0.00034 19.7 0.2 0.0011 18.0 0.2 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX57387.1 - 0.0014 18.0 0.0 0.0033 16.8 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX57387.1 - 0.01 15.8 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ORX57387.1 - 0.01 15.4 0.1 0.019 14.6 0.1 1.5 1 1 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 ORX57387.1 - 0.022 13.5 0.0 0.036 12.9 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase GRAM PF02893.20 ORX57388.1 - 5.6e-27 93.9 0.1 1.7e-26 92.3 0.0 1.8 2 0 0 2 2 2 1 GRAM domain Dicty_REP PF05086.12 ORX57388.1 - 0.11 10.5 1.5 0.14 10.2 1.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2052 PF09747.9 ORX57388.1 - 0.5 10.5 4.1 0.11 12.7 0.6 1.6 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Senescence_reg PF04520.13 ORX57388.1 - 0.98 10.2 7.0 2.5 8.9 7.0 1.6 1 0 0 1 1 1 0 Senescence regulator Red1 PF07964.11 ORX57388.1 - 3.2 5.9 8.7 0.3 9.3 3.7 1.7 2 0 0 2 2 2 0 Rec10 / Red1 UFD1 PF03152.14 ORX57389.1 - 2.2e-72 242.1 0.0 2.5e-72 241.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 SQS_PSY PF00494.19 ORX57389.1 - 0.0017 18.0 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase CDC48_N PF02359.18 ORX57389.1 - 0.019 15.1 0.0 1.5 9.0 0.0 2.8 1 1 1 2 2 2 0 Cell division protein 48 (CDC48), N-terminal domain Polysacc_deac_1 PF01522.21 ORX57390.1 - 4.1e-08 33.2 0.0 9.2e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Nuc_deoxyri_tr2 PF15891.5 ORX57390.1 - 0.16 12.3 0.0 12 6.3 0.0 2.3 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Abhydrolase_3 PF07859.13 ORX57391.1 - 2.9e-28 99.2 0.2 4.2e-28 98.7 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 ORX57391.1 - 3.3e-20 72.4 0.1 1.1e-19 70.8 0.1 1.6 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ORX57391.1 - 0.00017 21.1 0.3 0.0011 18.4 0.3 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ORX57391.1 - 0.0023 17.8 0.0 0.014 15.2 0.0 2.3 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 ORX57391.1 - 0.026 14.2 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ORX57391.1 - 0.029 14.0 0.0 0.059 13.0 0.0 1.5 1 1 1 2 2 2 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX57391.1 - 0.035 13.4 0.2 0.51 9.6 0.0 2.3 1 1 1 2 2 2 0 Serine aminopeptidase, S33 DAGAT PF03982.13 ORX57392.1 - 8.1e-94 313.9 0.0 1.1e-93 313.5 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Rer1 PF03248.13 ORX57392.1 - 0.00091 19.0 0.2 0.0017 18.1 0.2 1.4 1 0 0 1 1 1 1 Rer1 family Glyco_trans_2_3 PF13632.6 ORX57392.1 - 0.017 15.0 1.2 0.033 14.1 1.2 1.4 1 0 0 1 1 1 0 Glycosyl transferase family group 2 ABC2_membrane PF01061.24 ORX57394.1 - 7.1e-39 133.4 24.4 7.1e-39 133.4 24.4 2.3 3 0 0 3 3 3 1 ABC-2 type transporter ABC_tran PF00005.27 ORX57394.1 - 3.5e-29 102.1 0.0 5.8e-29 101.3 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX57394.1 - 4.7e-06 26.6 0.0 0.062 13.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX57394.1 - 0.0014 18.3 0.1 0.0041 16.8 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ORX57394.1 - 0.0028 17.1 0.0 0.0082 15.6 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX57394.1 - 0.0034 17.8 0.1 0.0092 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 ORX57394.1 - 0.0035 17.3 0.0 0.0065 16.4 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 ORX57394.1 - 0.0039 17.1 0.1 0.01 15.7 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ORX57394.1 - 0.0081 15.7 0.0 0.024 14.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX57394.1 - 0.019 15.2 0.0 0.052 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX57394.1 - 0.026 14.5 0.1 0.054 13.4 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ORX57394.1 - 0.027 15.0 0.0 0.055 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX57394.1 - 0.064 13.8 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ORX57394.1 - 0.089 12.4 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ORX57394.1 - 0.11 12.8 0.2 0.2 11.9 0.2 1.4 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX57394.1 - 0.16 12.4 0.1 0.91 10.0 0.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX57394.1 - 0.2 11.3 0.3 0.36 10.5 0.3 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX57394.1 - 0.23 11.1 0.1 0.61 9.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain Insulin_TMD PF17870.1 ORX57394.1 - 0.53 10.4 0.0 0.53 10.4 0.0 2.9 3 0 0 3 3 2 0 Insulin receptor trans-membrane segment ABC2_membrane_3 PF12698.7 ORX57394.1 - 0.58 9.2 32.6 0.21 10.6 29.4 1.8 1 1 1 2 2 2 0 ABC-2 family transporter protein CIAPIN1 PF05093.13 ORX57395.1 - 3.7e-21 75.5 17.2 2e-17 63.5 2.5 2.8 2 1 1 3 3 3 2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Pantoate_transf PF02548.15 ORX57396.1 - 1.9e-113 378.1 0.5 2.3e-113 377.9 0.5 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 ORX57396.1 - 0.00037 20.0 0.1 0.0011 18.5 0.1 1.8 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase IF3_C PF00707.22 ORX57397.1 - 2.3e-10 40.3 1.3 4.1e-10 39.5 1.3 1.4 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain IF3_N PF05198.16 ORX57397.1 - 1.2e-09 38.3 0.0 2.5e-09 37.3 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor IF-3, N-terminal domain mIF3 PF14877.6 ORX57397.1 - 0.00064 19.4 5.3 0.0014 18.4 5.3 1.5 1 0 0 1 1 1 1 Mitochondrial translation initiation factor DUF4342 PF14242.6 ORX57397.1 - 0.52 10.3 2.9 7.7 6.6 1.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4342) GREB1 PF15782.5 ORX57398.1 - 0.033 11.3 4.7 0.045 10.9 4.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ecl1 PF12855.7 ORX57399.1 - 5.5e-09 37.4 18.2 1.8e-08 35.7 18.2 1.6 1 1 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 ORX57399.1 - 0.0019 18.2 1.4 0.0047 17.0 1.4 1.6 1 0 0 1 1 1 1 MYND finger MSP1_C PF07462.11 ORX57399.1 - 0.51 9.0 0.6 0.57 8.8 0.6 1.0 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus CAF1C_H4-bd PF12265.8 ORX57400.1 - 5.4e-26 90.6 0.9 2.4e-25 88.6 0.5 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ORX57400.1 - 2.9e-25 88.0 10.9 0.00011 22.9 0.1 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57400.1 - 0.0043 17.3 1.4 1 9.7 0.1 3.7 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX57400.1 - 0.03 13.3 0.0 6.1 5.7 0.0 2.7 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ORX57400.1 - 0.14 11.5 0.0 0.29 10.4 0.0 1.5 1 0 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal Prenyltrans PF00432.21 ORX57401.1 - 8.9e-37 124.5 17.1 1.9e-08 33.9 0.1 5.7 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ORX57401.1 - 5.6e-05 22.4 0.0 1.3 8.0 0.0 3.7 2 1 1 4 4 4 3 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ORX57401.1 - 0.00048 19.3 0.3 0.4 9.7 0.1 3.2 1 1 1 3 3 3 2 Squalene-hopene cyclase N-terminal domain Rpr2 PF04032.16 ORX57403.1 - 1.1e-16 60.8 0.2 1.1e-16 60.8 0.2 2.0 3 0 0 3 3 3 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4674 PF15719.5 ORX57403.1 - 0.014 15.5 37.3 0.28 11.2 14.2 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4674) TFIIA PF03153.13 ORX57403.1 - 0.06 13.3 27.9 0.067 13.2 27.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SRP-alpha_N PF04086.13 ORX57403.1 - 1.1 9.1 22.3 1.6 8.6 22.3 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Ribosomal_L44 PF00935.19 ORX57403.1 - 3.2 8.3 12.8 0.53 10.8 1.1 3.8 2 1 2 4 4 4 0 Ribosomal protein L44 CDC27 PF09507.10 ORX57403.1 - 6.4 6.0 30.2 8.6 5.6 30.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Zn_clus PF00172.18 ORX57404.1 - 0.00039 20.5 17.1 0.00058 19.9 17.1 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FSH1 PF03959.13 ORX57405.1 - 7.3e-49 166.3 0.0 8.2e-49 166.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_1 PF00561.20 ORX57405.1 - 0.009 15.7 0.0 0.56 9.8 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF2235 PF09994.9 ORX57405.1 - 0.083 12.2 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Hydrolase_4 PF12146.8 ORX57405.1 - 0.18 11.1 0.0 0.65 9.2 0.0 2.0 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Nup35_RRM PF05172.13 ORX57406.1 - 4.4e-07 29.8 0.1 4.1e-06 26.7 0.1 2.1 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif DUF1866 PF08952.11 ORX57406.1 - 0.0026 17.6 0.0 0.0039 17.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1866) Nup35_RRM_2 PF14605.6 ORX57406.1 - 0.019 14.9 0.0 0.031 14.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Mito_carr PF00153.27 ORX57407.1 - 3.8e-38 129.3 2.4 4.4e-12 45.8 0.1 4.0 3 1 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 ORX57408.1 - 9.2e-20 70.6 23.9 8.3e-05 23.3 1.5 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat F-box-like PF12937.7 ORX57408.1 - 9.5e-08 31.8 0.5 2.2e-07 30.7 0.5 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ORX57408.1 - 2.8e-07 29.6 4.6 0.027 13.1 0.0 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX57408.1 - 2.7e-06 26.9 0.0 8.7e-06 25.3 0.0 1.7 1 1 1 2 2 2 1 WD40-like domain F-box PF00646.33 ORX57408.1 - 1.3e-05 25.0 0.4 1.3e-05 25.0 0.4 1.9 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 ORX57408.1 - 9.9e-05 22.6 0.2 0.26 11.6 0.0 4.0 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain F-box_4 PF15966.5 ORX57408.1 - 0.032 14.1 2.6 0.055 13.3 0.1 2.5 3 0 0 3 3 3 0 F-box Sipho_tail PF05709.11 ORX57408.1 - 0.1 12.0 0.0 0.21 11.0 0.0 1.4 1 1 0 1 1 1 0 Phage tail protein PAN_1 PF00024.26 ORX57408.1 - 0.18 11.8 0.7 0.38 10.8 0.7 1.5 1 0 0 1 1 1 0 PAN domain Nucleoporin_N PF08801.11 ORX57408.1 - 0.66 8.7 3.0 3.7 6.2 0.0 3.0 4 0 0 4 4 4 0 Nup133 N terminal like zf-C2H2 PF00096.26 ORX57409.1 - 1.4e-16 59.9 6.7 7.9e-08 32.4 0.7 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX57409.1 - 2.9e-10 40.1 6.1 0.00017 22.1 0.4 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX57409.1 - 1.8e-09 37.6 12.5 2.1e-08 34.2 2.1 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_aberr PF17017.5 ORX57409.1 - 3.2e-05 24.2 4.4 0.29 11.3 1.0 2.0 1 1 0 1 1 1 1 Aberrant zinc-finger zf-met PF12874.7 ORX57409.1 - 0.00066 20.0 3.1 0.39 11.2 0.3 2.5 3 0 0 3 3 2 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 ORX57409.1 - 0.0013 19.3 0.7 0.045 14.4 0.1 2.0 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-BED PF02892.15 ORX57409.1 - 0.0014 18.6 1.2 0.11 12.6 0.6 2.1 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_jaz PF12171.8 ORX57409.1 - 0.0016 18.7 8.7 0.071 13.4 0.2 2.7 3 1 0 3 3 2 2 Zinc-finger double-stranded RNA-binding zf-LYAR PF08790.11 ORX57409.1 - 0.0021 17.9 0.6 0.39 10.7 0.1 2.3 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger zf-H2C2_5 PF13909.6 ORX57409.1 - 0.022 14.5 11.9 0.34 10.7 0.2 2.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain IBR PF01485.21 ORX57409.1 - 0.035 14.3 1.4 0.23 11.7 0.2 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain CHORD PF04968.12 ORX57409.1 - 0.05 14.3 3.5 0.58 10.9 0.2 2.0 1 1 1 2 2 2 0 CHORD DUF4729 PF15866.5 ORX57409.1 - 0.056 12.7 1.8 1.4 8.2 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4729) Ogr_Delta PF04606.12 ORX57409.1 - 0.063 13.3 0.5 0.56 10.2 0.0 2.0 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-RAG1 PF10426.9 ORX57409.1 - 0.11 12.7 0.7 0.11 12.7 0.7 2.2 3 1 0 3 3 2 0 Recombination-activating protein 1 zinc-finger domain Transpos_assoc PF13963.6 ORX57409.1 - 0.15 12.4 2.7 0.16 12.3 0.9 1.8 1 1 1 2 2 2 0 Transposase-associated domain zf-C2H2_11 PF16622.5 ORX57409.1 - 0.55 10.0 5.1 4.9 7.0 1.0 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX57409.1 - 2.4 8.3 10.5 0.95 9.5 0.3 3.3 2 2 0 2 2 2 0 C2H2-type zinc finger DUF1007 PF06226.13 ORX57410.1 - 0.085 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) RIBIOP_C PF04950.12 ORX57411.1 - 6.7e-117 390.1 0.1 6.7e-117 390.1 0.1 1.8 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ORX57411.1 - 9.6e-23 80.1 0.0 2.8e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Borrelia_orfA PF02414.15 ORX57411.1 - 0.073 12.7 0.6 0.14 11.8 0.6 1.4 1 0 0 1 1 1 0 Borrelia ORF-A Myosin_N PF02736.19 ORX57411.1 - 0.28 11.0 0.8 0.81 9.6 0.1 2.0 2 0 0 2 2 2 0 Myosin N-terminal SH3-like domain WD40 PF00400.32 ORX57412.1 - 7.6e-23 80.4 1.4 3.9e-05 24.3 0.0 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57412.1 - 8.7e-10 38.8 0.0 0.057 13.7 0.0 4.3 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX57412.1 - 0.039 13.3 0.0 0.62 9.3 0.0 2.2 2 1 0 2 2 2 0 WD40-like domain DUF2415 PF10313.9 ORX57412.1 - 0.089 12.7 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) TRAPPC10 PF12584.8 ORX57413.1 - 3.2e-21 75.6 0.0 9.6e-21 74.1 0.0 1.8 2 0 0 2 2 2 1 Trafficking protein particle complex subunit 10, TRAPPC10 Gryzun-like PF12742.7 ORX57413.1 - 0.039 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Gryzun, putative Golgi trafficking Cullin PF00888.22 ORX57414.1 - 1.4e-169 565.7 9.8 1.7e-169 565.4 9.8 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX57414.1 - 1e-22 79.9 2.1 3.5e-22 78.2 1.1 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain TnsD PF15978.5 ORX57414.1 - 0.0057 15.7 0.3 0.012 14.6 0.3 1.5 1 0 0 1 1 1 1 Tn7-like transposition protein D GP40 PF11025.8 ORX57415.1 - 0.14 11.9 0.1 0.14 11.9 0.1 1.8 2 0 0 2 2 2 0 Glycoprotein GP40 of Cryptosporidium Lipase_GDSL_2 PF13472.6 ORX57416.1 - 1.3e-07 32.2 0.9 2e-07 31.6 0.9 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ORX57416.1 - 0.00065 19.7 0.1 0.001 19.1 0.1 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Spore_SspJ PF09575.10 ORX57416.1 - 0.13 12.6 0.4 0.26 11.7 0.4 1.4 1 0 0 1 1 1 0 Small spore protein J (Spore_SspJ) TLD PF07534.16 ORX57417.1 - 4.6e-24 85.2 0.0 8.6e-24 84.3 0.0 1.5 1 0 0 1 1 1 1 TLD DUF3819 PF12842.7 ORX57417.1 - 0.028 14.4 0.0 0.054 13.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) AraC_binding PF02311.19 ORX57417.1 - 0.087 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AraC-like ligand binding domain F-box-like PF12937.7 ORX57418.1 - 0.0094 15.8 3.3 0.13 12.2 1.0 2.9 2 0 0 2 2 2 2 F-box-like DPBB_1 PF03330.18 ORX57420.1 - 2.5e-05 24.5 0.1 4.2e-05 23.7 0.1 1.5 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX57420.1 - 9.4e-05 22.3 0.3 0.00012 21.9 0.3 1.4 1 1 0 1 1 1 1 Barwin family FOXP-CC PF16159.5 ORX57421.1 - 0.0012 19.4 0.7 0.0016 19.0 0.7 1.3 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-C2H2 PF00096.26 ORX57421.1 - 0.024 15.1 1.6 0.05 14.1 1.6 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF2110 PF09883.9 ORX57421.1 - 0.14 11.8 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2110) IBR PF01485.21 ORX57422.1 - 1.9e-11 44.0 15.7 4.8e-09 36.3 5.6 4.5 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 ORX57422.1 - 0.00014 22.1 8.9 0.00014 22.1 8.9 4.3 3 1 1 4 4 4 2 Ring finger domain Prok-RING_4 PF14447.6 ORX57422.1 - 0.0029 17.4 6.2 0.0029 17.4 6.2 4.7 3 2 0 4 4 4 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ORX57422.1 - 0.0043 16.9 5.6 0.0043 16.9 5.6 4.8 5 0 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX57422.1 - 0.011 15.6 8.2 0.011 15.6 8.2 4.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX57422.1 - 0.03 14.3 8.1 0.03 14.3 8.1 4.1 4 0 0 4 4 4 0 zinc-RING finger domain dCMP_cyt_deam_1 PF00383.23 ORX57422.1 - 0.28 11.1 3.1 17 5.3 0.2 3.0 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF1244 PF06844.11 ORX57422.1 - 0.33 11.2 2.4 21 5.4 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1244) Lzipper-MIP1 PF14389.6 ORX57424.1 - 0.00061 20.0 2.6 0.0025 18.1 2.6 2.1 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 Response_reg PF00072.24 ORX57425.1 - 2.6e-21 75.9 0.0 1.9e-14 53.8 0.1 2.5 2 0 0 2 2 2 2 Response regulator receiver domain SCO1-SenC PF02630.14 ORX57426.1 - 4.1e-44 149.7 0.0 6.6e-44 149.1 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 ORX57426.1 - 0.00019 21.7 0.0 0.00044 20.5 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 ORX57426.1 - 0.00039 20.3 0.0 0.00099 19.0 0.0 1.6 2 0 0 2 2 2 1 AhpC/TSA family zf-C2H2_jaz PF12171.8 ORX57428.1 - 4.2e-11 42.8 1.3 6.6e-11 42.2 1.3 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX57428.1 - 0.038 14.4 0.7 0.061 13.7 0.7 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ORX57428.1 - 0.096 13.0 1.2 0.11 12.8 1.2 1.3 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) SYF2 PF08231.12 ORX57428.1 - 0.22 11.9 6.0 0.4 11.1 6.0 1.4 1 1 0 1 1 1 0 SYF2 splicing factor DEAD PF00270.29 ORX57429.1 - 6.3e-36 123.8 0.0 1.1e-35 123.0 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX57429.1 - 5.4e-26 91.1 0.0 3.6e-24 85.2 0.0 2.9 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX57429.1 - 1e-08 35.4 0.0 1.6e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ORX57429.1 - 0.00094 19.5 0.0 0.0021 18.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ORX57429.1 - 0.0097 15.6 0.0 0.02 14.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ORX57429.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 Helicase Homeodomain PF00046.29 ORX57430.1 - 7.1e-19 67.4 4.7 8e-19 67.2 4.7 1.0 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX57430.1 - 0.024 14.5 0.2 0.024 14.5 0.2 1.6 2 0 0 2 2 2 0 Homeobox KN domain DUF1476 PF07345.11 ORX57430.1 - 0.048 14.0 0.3 0.055 13.8 0.3 1.1 1 0 0 1 1 1 0 ATPase inhibitor subunit zeta YdaS_antitoxin PF15943.5 ORX57430.1 - 0.048 13.5 0.1 0.06 13.2 0.1 1.1 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_28 PF13518.6 ORX57430.1 - 0.057 13.5 0.1 0.057 13.5 0.1 1.5 2 0 0 2 2 2 0 Helix-turn-helix domain CLASP_N PF12348.8 ORX57431.1 - 3.5e-27 95.5 3.9 4.3e-27 95.1 3.9 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 ORX57431.1 - 0.015 15.5 0.9 0.19 12.1 0.2 3.0 3 0 0 3 3 3 0 HEAT repeat IBN_N PF03810.19 ORX57431.1 - 0.051 13.5 0.8 0.22 11.5 0.1 2.4 3 0 0 3 3 3 0 Importin-beta N-terminal domain DUF1981 PF09324.10 ORX57431.1 - 0.096 12.5 1.1 0.45 10.4 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) SIKE PF05769.11 ORX57432.1 - 9.5e-07 28.9 6.5 1.5e-06 28.3 6.1 1.6 1 1 0 1 1 1 1 SIKE family HALZ PF02183.18 ORX57432.1 - 0.65 10.3 11.9 2.3 8.5 1.6 3.7 3 1 0 3 3 3 0 Homeobox associated leucine zipper GIT_CC PF16559.5 ORX57432.1 - 7.8 6.5 9.5 2.9 7.8 1.0 3.0 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4708 PF15813.5 ORX57433.1 - 0.049 12.8 0.0 0.079 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4708) Peptidase_S8 PF00082.22 ORX57434.1 - 6.1e-29 101.2 10.1 9.8e-29 100.5 9.9 1.4 1 1 0 1 1 1 1 Subtilase family Polysacc_deac_1 PF01522.21 ORX57435.1 - 1.8e-28 98.9 0.0 4.1e-28 97.8 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 ORX57435.1 - 5.6e-10 38.9 0.0 7.2e-10 38.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF2334 PF10096.9 ORX57435.1 - 0.0061 16.2 0.1 0.01 15.5 0.1 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) BEN PF10523.9 ORX57435.1 - 0.16 12.2 0.0 7.2 6.9 0.0 2.4 2 0 0 2 2 2 0 BEN domain AP_endonuc_2 PF01261.24 ORX57435.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.5 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel Hexokinase_2 PF03727.16 ORX57436.1 - 2.1e-60 204.1 0.1 3e-60 203.6 0.1 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX57436.1 - 9.7e-36 123.5 0.0 1.4e-35 123.0 0.0 1.2 1 0 0 1 1 1 1 Hexokinase F-box PF00646.33 ORX57436.1 - 0.023 14.6 0.4 11 6.0 0.0 2.9 3 0 0 3 3 3 0 F-box domain DRY_EERY PF09750.9 ORX57438.1 - 7.1e-28 97.6 0.1 1.9e-27 96.2 0.0 1.8 2 0 0 2 2 2 1 Alternative splicing regulator DUF3899 PF13038.6 ORX57438.1 - 0.3 11.6 1.2 1.7 9.2 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) Ribosomal_S8 PF00410.19 ORX57440.1 - 3.4e-22 78.8 0.0 4.5e-22 78.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 LAGLIDADG_WhiA PF14527.6 ORX57440.1 - 0.13 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain Pescadillo_N PF06732.11 ORX57441.1 - 8.5e-121 402.7 4.0 8.5e-121 402.7 4.0 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 ORX57441.1 - 1.9e-09 37.8 0.0 5.3e-09 36.4 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ORX57441.1 - 0.0069 16.7 0.0 0.064 13.6 0.0 2.5 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Kinesin PF00225.23 ORX57442.1 - 2.6e-78 263.3 2.4 1e-75 254.7 0.1 3.0 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX57442.1 - 4.5e-09 36.4 0.3 1.8e-07 31.2 0.0 2.9 2 1 0 2 2 2 1 Microtubule binding LPD37 PF18853.1 ORX57442.1 - 0.067 12.7 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Large polyvalent protein associated domain 37 DUF1664 PF07889.12 ORX57442.1 - 0.63 10.1 18.6 0.2 11.7 1.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ORX57442.1 - 1.5 9.0 31.3 5.1 7.3 18.6 3.2 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ORX57442.1 - 5.5 5.8 34.2 0.035 13.0 7.6 3.3 3 0 0 3 3 3 0 Spc7 kinetochore protein Ribosomal_L1 PF00687.21 ORX57443.1 - 6.9e-32 110.8 0.6 1.1e-31 110.2 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Ribosomal_L5_C PF00673.21 ORX57443.1 - 3.2e-26 91.3 0.0 6.4e-26 90.4 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ORX57443.1 - 2.7e-11 43.6 0.0 5.9e-11 42.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L5 Asn_synthase PF00733.21 ORX57444.1 - 4.5e-76 256.8 0.0 5.8e-76 256.5 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 ORX57444.1 - 5.8e-41 139.3 0.0 1.2e-40 138.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ORX57444.1 - 7e-35 120.1 0.0 2.2e-34 118.5 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase domain DUF1910 PF08928.10 ORX57444.1 - 0.049 13.6 0.0 0.88 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1910) NAD_synthase PF02540.17 ORX57444.1 - 0.076 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 NAD synthase DUF3700 PF12481.8 ORX57444.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Aluminium induced protein DHHC PF01529.20 ORX57445.1 - 1.5e-34 118.9 10.3 1.5e-34 118.9 10.3 2.5 3 0 0 3 3 3 1 DHHC palmitoyltransferase Reticulon PF02453.17 ORX57446.1 - 8.5e-28 97.3 2.6 1.1e-27 96.9 2.6 1.2 1 0 0 1 1 1 1 Reticulon Glyco_transf_15 PF01793.16 ORX57448.1 - 5.9e-67 226.2 8.8 6.7e-67 226.1 8.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CUE PF02845.16 ORX57449.1 - 2.9e-07 30.1 0.0 4.6e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 CUE domain Rhomboid PF01694.22 ORX57449.1 - 0.00017 21.6 7.4 0.00021 21.3 6.6 1.6 1 1 1 2 2 2 1 Rhomboid family UBA PF00627.31 ORX57449.1 - 0.14 12.1 0.1 0.34 10.9 0.1 1.7 1 1 0 1 1 1 0 UBA/TS-N domain Ribosomal_L7Ae PF01248.26 ORX57450.1 - 4.8e-26 90.3 0.0 5.9e-26 90.0 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ORX57450.1 - 0.00011 22.3 0.0 0.00011 22.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 ORX57450.1 - 0.00061 19.6 0.0 0.00085 19.2 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain DUF1921 PF09081.10 ORX57451.1 - 0.019 15.2 5.5 0.19 12.0 1.8 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1921) DUF4625 PF15418.6 ORX57451.1 - 0.064 13.5 0.0 0.087 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) ETC_C1_NDUFA5 PF04716.14 ORX57452.1 - 1.3e-27 95.4 0.3 2.2e-27 94.6 0.3 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region ParA PF10609.9 ORX57453.1 - 2.4e-98 328.5 0.0 2.9e-98 328.3 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ORX57453.1 - 9.8e-10 38.6 0.0 9.6e-09 35.4 0.0 2.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ORX57453.1 - 1.8e-07 31.2 0.1 9e-07 29.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 ORX57453.1 - 8.9e-06 25.1 0.0 4.7e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 ORX57453.1 - 0.00047 19.7 0.0 0.33 10.3 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family RsgA_GTPase PF03193.16 ORX57453.1 - 0.0025 17.7 0.0 0.005 16.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 ORX57453.1 - 0.0027 17.3 0.0 0.0037 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 ORX57453.1 - 0.011 15.0 0.0 0.03 13.6 0.0 1.7 1 1 0 1 1 1 0 ATPase MipZ AAA_26 PF13500.6 ORX57453.1 - 0.013 15.3 0.0 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 ORX57453.1 - 0.014 14.9 0.1 0.09 12.2 0.1 2.0 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ AAA_16 PF13191.6 ORX57453.1 - 0.038 14.4 0.0 0.072 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ORX57453.1 - 0.11 12.4 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 ORX57453.1 - 0.11 11.4 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB SMC_N PF02463.19 ORX57453.1 - 0.15 11.5 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain TsaE PF02367.17 ORX57453.1 - 0.2 11.7 0.0 0.34 10.9 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Anti-TRAP PF15777.5 ORX57453.1 - 0.2 11.6 0.0 0.2 11.6 0.0 1.8 2 0 0 2 2 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein SNARE PF05739.19 ORX57454.1 - 2.4e-06 27.4 0.5 2.4e-06 27.4 0.5 2.2 2 0 0 2 2 2 1 SNARE domain Use1 PF09753.9 ORX57454.1 - 0.0014 18.4 2.9 0.0025 17.6 2.9 1.5 1 1 0 1 1 1 1 Membrane fusion protein Use1 Transcrip_act PF04949.13 ORX57454.1 - 0.006 16.5 3.3 0.021 14.7 0.8 2.2 2 0 0 2 2 2 1 Transcriptional activator Cas9_a PF18470.1 ORX57454.1 - 0.0073 15.9 0.5 0.011 15.2 0.4 1.6 1 1 0 1 1 1 1 Cas9 alpha-helical lobe domain EzrA PF06160.12 ORX57454.1 - 0.0077 14.5 0.6 0.0077 14.5 0.6 1.7 2 0 0 2 2 2 1 Septation ring formation regulator, EzrA Tropomyosin_1 PF12718.7 ORX57454.1 - 1.2 9.3 12.5 2 8.5 1.6 2.4 2 0 0 2 2 2 0 Tropomyosin like WD40 PF00400.32 ORX57455.1 - 4.6e-10 39.9 4.5 0.0067 17.3 0.0 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57455.1 - 0.00012 22.4 0.0 3 8.2 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ORX57455.1 - 0.0098 13.9 0.0 0.6 8.0 0.0 2.1 2 0 0 2 2 2 2 IKI3 family PD40 PF07676.12 ORX57455.1 - 0.013 15.5 0.1 0.82 9.7 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ORX57455.1 - 0.03 14.2 0.0 0.14 12.0 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX57455.1 - 0.096 11.2 0.0 0.32 9.5 0.0 1.8 1 1 0 1 1 1 0 Cytochrome D1 heme domain Thioredoxin_4 PF13462.6 ORX57456.1 - 2.3e-12 47.4 0.0 3.3e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 ORX57456.1 - 0.069 12.9 0.9 0.21 11.3 0.2 2.1 2 1 1 3 3 3 0 DSBA-like thioredoxin domain Pro_isomerase PF00160.21 ORX57457.1 - 5.2e-49 166.5 0.1 7.8e-49 166.0 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 ORX57457.1 - 3.7e-08 32.9 11.3 0.024 14.5 2.6 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX57457.1 - 7.1e-08 32.0 8.8 0.0088 16.1 1.2 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX57457.1 - 1e-05 25.7 0.7 0.01 16.1 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX57457.1 - 0.00046 19.8 6.4 0.0049 16.5 0.9 3.0 2 1 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 ORX57457.1 - 0.0052 17.3 6.3 2.6 8.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX57457.1 - 0.013 15.7 6.7 2.7 8.4 0.1 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ORX57457.1 - 0.016 15.0 0.0 0.027 14.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) TPR_7 PF13176.6 ORX57457.1 - 0.26 11.4 3.3 1.6 8.9 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX57457.1 - 0.39 11.7 6.2 2.2 9.3 1.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX57457.1 - 3.6 8.3 6.4 5.7 7.7 2.4 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat GARS_A PF01071.19 ORX57459.1 - 3e-84 281.6 0.0 5.7e-84 280.7 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 ORX57459.1 - 4.4e-35 121.1 0.0 1.3e-34 119.6 0.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 ORX57459.1 - 2e-33 115.0 0.1 6.3e-33 113.4 0.1 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 ORX57459.1 - 1.7e-29 101.9 0.2 6.2e-29 100.1 0.2 2.0 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 ORX57459.1 - 5.6e-15 55.8 2.4 1.3e-14 54.6 0.7 2.5 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 ORX57459.1 - 8e-05 22.3 0.7 0.00016 21.3 0.1 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_3 PF02655.14 ORX57459.1 - 0.0012 18.9 0.0 0.0058 16.7 0.0 2.1 1 1 0 1 1 1 1 ATP-grasp domain Pox_MCEL PF03291.16 ORX57459.1 - 0.061 12.4 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 mRNA capping enzyme CPSase_L_D2 PF02786.17 ORX57459.1 - 0.075 12.5 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.6 ORX57459.1 - 0.11 11.7 0.0 0.58 9.3 0.0 1.9 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 ORX57459.1 - 0.16 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain NLPC_P60 PF00877.19 ORX57460.1 - 3.1e-18 65.7 1.0 5.6e-18 64.9 1.0 1.4 1 0 0 1 1 1 1 NlpC/P60 family Serglycin PF04360.12 ORX57460.1 - 0.015 15.3 10.8 0.022 14.7 9.9 1.7 2 0 0 2 2 2 0 Serglycin START PF01852.19 ORX57461.1 - 6.8e-13 48.5 0.4 1.8e-06 27.5 0.2 2.4 2 0 0 2 2 2 2 START domain SUIM_assoc PF16619.5 ORX57461.1 - 0.013 15.6 0.3 0.013 15.6 0.3 3.6 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 SET PF00856.28 ORX57462.1 - 7.3e-09 36.2 0.0 8.7e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 SET domain CK1gamma_C PF12605.8 ORX57462.1 - 0.054 14.7 0.0 0.084 14.1 0.0 1.3 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal adh_short PF00106.25 ORX57463.1 - 4.4e-47 160.1 2.1 6e-47 159.6 2.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX57463.1 - 8.1e-41 140.1 0.3 1.2e-40 139.6 0.3 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX57463.1 - 6.1e-09 36.0 1.6 1.9e-08 34.4 1.6 1.7 1 1 0 1 1 1 1 KR domain T4SS-DNA_transf PF02534.14 ORX57463.1 - 0.12 11.1 0.0 0.19 10.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer Epimerase PF01370.21 ORX57463.1 - 0.14 11.6 0.6 0.33 10.4 0.6 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family UCH PF00443.29 ORX57464.1 - 1.5e-43 149.2 0.0 1.8e-43 148.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ORX57464.1 - 2.3e-12 46.5 0.3 2.1e-11 43.4 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family UCH_1 PF13423.6 ORX57464.1 - 6.1e-12 45.8 0.5 2.9e-11 43.6 0.5 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Med9 PF07544.13 ORX57464.1 - 0.054 13.6 0.4 0.14 12.3 0.4 1.7 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TBK1_ULD PF18396.1 ORX57464.1 - 0.062 13.2 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain TPPII_N PF12583.8 ORX57464.1 - 0.12 12.9 0.4 0.25 11.9 0.4 1.5 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Peptidase_C98 PF15499.6 ORX57464.1 - 0.24 10.8 0.8 0.64 9.5 0.2 2.0 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase adh_short PF00106.25 ORX57465.1 - 5.1e-44 150.1 3.2 6.8e-44 149.7 3.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX57465.1 - 7.7e-36 123.8 1.8 9.5e-36 123.5 1.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX57465.1 - 3.1e-07 30.5 1.4 7.5e-07 29.2 1.4 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX57465.1 - 0.038 13.4 0.2 0.052 13.0 0.2 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family YjeF_N PF03853.15 ORX57465.1 - 0.084 12.8 0.3 0.15 11.9 0.3 1.4 1 0 0 1 1 1 0 YjeF-related protein N-terminus Ribosomal_L12 PF00542.19 ORX57465.1 - 0.14 12.5 0.7 0.41 11.0 0.7 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 C-terminal domain CLTH PF10607.9 ORX57466.1 - 2.9e-30 105.1 0.5 6.7e-30 103.9 0.0 1.8 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 ORX57466.1 - 8.8e-09 35.3 0.5 8.8e-09 35.3 0.5 2.3 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX57466.1 - 3e-06 27.1 1.0 8.1e-06 25.7 1.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ORX57466.1 - 7.9e-05 22.9 1.3 0.0002 21.6 1.3 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ORX57466.1 - 0.00035 20.4 1.2 0.00097 19.0 1.2 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Rtf2 PF04641.12 ORX57466.1 - 0.00062 19.2 0.1 0.00062 19.2 0.1 2.1 2 0 0 2 2 2 1 Rtf2 RING-finger zf-C3HC4_3 PF13920.6 ORX57466.1 - 0.0013 18.5 1.1 0.003 17.4 1.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX57466.1 - 0.0034 17.5 1.2 0.012 15.8 1.2 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING OmpH PF03938.14 ORX57466.1 - 0.0035 17.7 7.2 0.0035 17.7 7.2 2.0 2 0 0 2 2 2 1 Outer membrane protein (OmpH-like) zf-C3HC4 PF00097.25 ORX57466.1 - 0.0063 16.4 2.7 0.01 15.7 1.4 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Cortex-I_coil PF09304.10 ORX57466.1 - 0.057 13.6 1.1 0.13 12.5 1.1 1.6 1 0 0 1 1 1 0 Cortexillin I, coiled coil DUF2564 PF10819.8 ORX57466.1 - 0.073 13.5 4.2 0.77 10.2 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2564) zf-C3HC4_2 PF13923.6 ORX57466.1 - 0.11 12.4 4.1 0.52 10.2 4.1 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Fib_alpha PF08702.10 ORX57466.1 - 0.14 12.4 5.7 0.074 13.2 2.9 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Cep57_MT_bd PF06657.13 ORX57466.1 - 0.21 12.1 4.9 0.25 11.8 1.1 2.4 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF1664 PF07889.12 ORX57466.1 - 0.24 11.4 3.3 0.4 10.7 1.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 ORX57466.1 - 0.26 10.8 2.4 0.38 10.3 2.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med11 PF10280.9 ORX57466.1 - 0.3 11.5 3.3 0.63 10.5 3.3 1.5 1 0 0 1 1 1 0 Mediator complex protein DUF4795 PF16043.5 ORX57466.1 - 7.4 6.1 11.1 4.6 6.8 5.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Aminotran_1_2 PF00155.21 ORX57467.1 - 4e-43 148.0 0.0 4.8e-43 147.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ORX57467.1 - 0.013 14.0 0.0 0.019 13.5 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ORX57467.1 - 0.042 13.1 0.0 0.063 12.5 0.0 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX57467.1 - 0.052 12.5 0.0 0.075 12.0 0.0 1.1 1 0 0 1 1 1 0 Aminotransferase class-V Mcp5_PH PF12814.7 ORX57468.1 - 1.4e-24 86.5 0.8 3.6e-24 85.2 0.8 1.6 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Filament PF00038.21 ORX57468.1 - 0.062 12.9 33.7 0.03 13.9 23.1 2.6 2 0 0 2 2 2 0 Intermediate filament protein Prominin PF05478.11 ORX57468.1 - 9.9 4.0 10.6 25 2.6 10.6 1.6 1 0 0 1 1 1 0 Prominin bZIP_1 PF00170.21 ORX57469.1 - 7.4e-10 38.8 8.7 3.1e-09 36.8 8.4 1.9 1 1 1 2 2 2 1 bZIP transcription factor FlaC_arch PF05377.11 ORX57469.1 - 0.0044 17.4 0.5 0.0073 16.7 0.5 1.3 1 0 0 1 1 1 1 Flagella accessory protein C (FlaC) PHA_synth_III_E PF09712.10 ORX57469.1 - 0.0072 15.4 0.0 0.01 14.9 0.0 1.1 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) GIT_CC PF16559.5 ORX57469.1 - 0.026 14.4 0.5 0.098 12.5 0.5 1.9 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_2 PF07716.15 ORX57469.1 - 0.078 13.1 13.1 0.6 10.2 11.7 2.3 1 1 1 2 2 2 0 Basic region leucine zipper DUF3450 PF11932.8 ORX57469.1 - 0.085 12.1 5.2 0.13 11.6 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ORX57469.1 - 0.23 11.2 4.0 0.18 11.6 2.3 1.6 1 1 0 1 1 1 0 Septum formation initiator Phage_GP20 PF06810.11 ORX57469.1 - 0.39 10.5 5.8 0.22 11.3 3.4 1.7 2 0 0 2 2 2 0 Phage minor structural protein GP20 FliD_N PF02465.18 ORX57469.1 - 0.48 11.1 3.1 0.83 10.4 3.1 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus UPF0242 PF06785.11 ORX57469.1 - 0.53 10.4 8.6 1.5 8.9 1.4 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus LETM1 PF07766.13 ORX57469.1 - 0.57 9.5 5.8 2.2 7.5 2.2 2.1 2 0 0 2 2 2 0 LETM1-like protein ADIP PF11559.8 ORX57469.1 - 3.4 7.7 10.1 20 5.2 9.2 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 ORX57469.1 - 5.5 6.1 5.2 7 5.8 5.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein GalKase_gal_bdg PF10509.9 ORX57470.1 - 5e-21 74.0 0.0 8.7e-21 73.2 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ORX57470.1 - 1.4e-15 57.3 2.4 2.6e-15 56.4 2.4 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ORX57470.1 - 2.7e-12 46.9 0.0 7.4e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal Zds_C PF08632.10 ORX57470.1 - 0.048 13.4 0.1 0.11 12.3 0.1 1.6 1 0 0 1 1 1 0 Activator of mitotic machinery Cdc14 phosphatase activation C-term Stc1 PF12898.7 ORX57471.1 - 1.2e-18 67.4 14.0 2.2e-18 66.6 14.1 1.4 1 1 0 1 1 1 1 Stc1 domain TackOD1 PF18551.1 ORX57471.1 - 0.18 11.5 10.1 1.7 8.3 7.0 2.7 2 1 1 3 3 3 0 Thaumarchaeal output domain 1 Lar_restr_allev PF14354.6 ORX57471.1 - 1.6 9.2 9.7 13 6.2 9.7 2.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar LIM_bind PF01803.16 ORX57472.1 - 5.9e-36 124.2 0.0 5.9e-36 124.2 0.0 3.2 3 1 0 3 3 3 1 LIM-domain binding protein Pkinase PF00069.25 ORX57473.1 - 6.3e-75 251.9 0.0 7.2e-75 251.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX57473.1 - 7.6e-32 110.6 0.0 1e-31 110.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX57473.1 - 0.00087 18.7 0.2 0.013 14.8 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX57473.1 - 0.011 14.7 0.0 0.12 11.2 0.0 2.0 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX57473.1 - 0.014 15.3 0.3 0.032 14.2 0.2 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ORX57473.1 - 0.017 14.7 0.3 0.028 14.0 0.3 1.3 1 0 0 1 1 1 0 RIO1 family Peptidase_S8 PF00082.22 ORX57474.1 - 2.6e-28 99.2 0.2 3.5e-28 98.7 0.2 1.2 1 0 0 1 1 1 1 Subtilase family PA PF02225.22 ORX57474.1 - 2e-09 37.4 1.6 4.7e-09 36.1 0.2 2.1 2 0 0 2 2 2 1 PA domain fn3_5 PF06280.12 ORX57474.1 - 5.2e-05 23.9 0.0 0.067 13.9 0.0 2.4 2 0 0 2 2 2 2 Fn3-like domain NDUF_B12 PF08122.12 ORX57475.1 - 3.7e-25 87.7 1.0 4.7e-25 87.4 1.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family Acetyltransf_1 PF00583.25 ORX57476.1 - 4.2e-11 43.1 0.1 1.1e-10 41.7 0.1 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 ORX57476.1 - 0.0005 20.7 2.3 0.083 13.6 0.5 3.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX57476.1 - 0.0038 17.3 0.1 0.24 11.5 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX57476.1 - 0.0047 17.3 0.0 0.051 14.0 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX57476.1 - 0.01 15.8 0.0 0.11 12.4 0.0 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF2232 PF09991.9 ORX57476.1 - 0.034 13.3 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) SRP9-21 PF05486.12 ORX57476.1 - 0.042 14.2 0.1 2 8.9 0.1 2.2 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Phage_lysozyme PF00959.19 ORX57477.1 - 5e-20 72.0 0.0 7.5e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Phage lysozyme Serglycin PF04360.12 ORX57477.1 - 0.0083 16.1 6.5 0.014 15.4 6.5 1.3 1 0 0 1 1 1 1 Serglycin AF-4 PF05110.13 ORX57477.1 - 1.6 6.7 2.3 2.1 6.3 2.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein HAP1_N PF04849.13 ORX57478.1 - 8e-06 25.3 6.4 8e-06 25.3 6.4 2.6 2 1 1 3 3 3 1 HAP1 N-terminal conserved region Pox_A_type_inc PF04508.12 ORX57478.1 - 0.074 12.9 2.8 0.17 11.8 0.0 3.1 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat GCN5L1 PF06320.13 ORX57478.1 - 0.31 11.2 12.1 0.14 12.3 2.6 2.3 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) TerY_C PF15616.6 ORX57478.1 - 0.76 9.9 3.4 8.6 6.5 0.5 2.4 2 0 0 2 2 2 0 TerY-C metal binding domain Pyr_redox_2 PF07992.14 ORX57479.1 - 1e-45 156.3 0.0 1.6e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX57479.1 - 1.8e-18 66.9 0.0 1.5e-13 51.1 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_7 PF13499.6 ORX57479.1 - 1.5e-13 51.0 4.4 1.8e-10 41.1 1.5 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ORX57479.1 - 2.5e-12 45.7 1.3 6.4e-06 25.4 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 ORX57479.1 - 4.3e-12 44.7 4.2 1.7e-05 24.0 0.5 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ORX57479.1 - 5.8e-11 41.4 1.8 0.00034 20.3 0.2 2.7 2 0 0 2 2 2 2 EF-hand domain Pyr_redox_3 PF13738.6 ORX57479.1 - 0.00028 20.2 1.5 0.49 9.6 0.1 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase EF-hand_8 PF13833.6 ORX57479.1 - 0.0033 17.2 0.7 0.32 10.9 0.3 2.4 2 0 0 2 2 2 1 EF-hand domain pair NAD_binding_8 PF13450.6 ORX57479.1 - 0.0039 17.4 0.0 4.8 7.5 0.0 3.1 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain DUF445 PF04286.12 ORX57479.1 - 0.004 17.0 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF445) EF-hand_4 PF12763.7 ORX57479.1 - 0.027 14.4 2.8 1.1 9.2 0.2 3.2 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand K_oxygenase PF13434.6 ORX57479.1 - 0.036 13.2 0.0 3.6 6.6 0.0 2.4 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) SPARC_Ca_bdg PF10591.9 ORX57479.1 - 0.32 11.3 1.2 13 6.1 0.8 2.3 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DAO PF01266.24 ORX57479.1 - 0.33 10.5 1.9 3.9 7.0 0.0 2.9 1 1 1 2 2 2 0 FAD dependent oxidoreductase Ribosomal_L3 PF00297.22 ORX57480.1 - 1.8e-18 66.7 2.6 4.1e-15 55.6 0.3 3.0 1 1 2 3 3 3 2 Ribosomal protein L3 WD40 PF00400.32 ORX57481.1 - 1.3e-24 86.0 10.4 6.8e-06 26.7 0.1 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57481.1 - 2.1e-07 31.1 1.8 1.5 9.2 0.0 5.0 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX57481.1 - 1.9e-05 23.5 0.4 0.13 10.9 0.0 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX57481.1 - 0.0013 18.2 0.0 0.64 9.3 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 ORX57481.1 - 0.0025 16.6 0.7 0.64 8.7 0.0 3.1 1 1 1 3 3 3 1 Nup133 N terminal like BBS2_Mid PF14783.6 ORX57481.1 - 0.0047 17.0 0.0 0.059 13.4 0.0 2.5 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Coatomer_WDAD PF04053.14 ORX57481.1 - 0.01 14.9 0.0 0.014 14.5 0.0 1.1 1 0 0 1 1 1 0 Coatomer WD associated region eIF2A PF08662.11 ORX57481.1 - 0.012 15.5 0.1 0.097 12.5 0.1 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ORX57481.1 - 0.1 12.2 0.2 3.8 7.0 0.0 2.1 1 1 0 2 2 2 0 PQQ-like domain DUF4529 PF15032.6 ORX57481.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4529) EHD_N PF16880.5 ORX57481.1 - 0.14 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 N-terminal EH-domain containing protein Fungal_trans PF04082.18 ORX57482.1 - 1e-14 54.2 5.1 1.8e-14 53.4 5.1 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX57482.1 - 2.8e-11 43.3 13.6 4.6e-11 42.7 13.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PADR1 PF08063.12 ORX57482.1 - 5.3 6.9 7.7 8.8 6.2 7.7 1.3 1 0 0 1 1 1 0 PADR1 (NUC008) domain DUF1394 PF07159.12 ORX57483.1 - 9.5e-76 254.9 0.0 1.1e-75 254.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Ribonuc_2-5A PF06479.12 ORX57483.1 - 0.015 15.4 0.0 9 6.5 0.0 2.4 2 0 0 2 2 2 0 Ribonuclease 2-5A Aminotran_3 PF00202.21 ORX57484.1 - 3e-43 148.0 0.0 1.1e-23 83.6 0.0 3.3 2 2 0 2 2 2 2 Aminotransferase class-III AAA_26 PF13500.6 ORX57484.1 - 1.5e-21 77.1 0.0 2.5e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Peptidase_S8 PF00082.22 ORX57485.1 - 5.1e-46 157.3 0.0 1.1e-45 156.2 0.0 1.4 1 1 0 1 1 1 1 Subtilase family PA PF02225.22 ORX57485.1 - 7.3e-11 41.9 0.0 1.9e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 PA domain Methyltransf_16 PF10294.9 ORX57486.1 - 1.3e-25 90.1 0.4 4e-25 88.6 0.4 1.7 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ORX57486.1 - 0.031 13.8 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Lactamase_B_6 PF16661.5 ORX57486.1 - 0.044 13.2 0.0 0.08 12.4 0.0 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain DOCK_N PF16172.5 ORX57487.1 - 8.1e-89 298.2 0.7 9.8e-71 238.6 0.1 3.0 3 0 0 3 3 3 2 DOCK N-terminus DHR-2 PF06920.13 ORX57487.1 - 1.8e-77 261.2 0.3 2.2e-41 142.1 0.4 3.0 2 1 0 2 2 2 2 Dock homology region 2 DOCK-C2 PF14429.6 ORX57487.1 - 1.7e-32 112.9 0.0 3.7e-31 108.5 0.0 2.5 1 1 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins Imm43 PF15570.6 ORX57487.1 - 0.15 12.1 0.0 0.45 10.5 0.0 1.8 1 0 0 1 1 1 0 Immunity protein 43 DNA_PPF PF02916.15 ORX57490.1 - 0.019 15.3 0.5 0.051 14.0 0.5 1.7 1 0 0 1 1 1 0 DNA polymerase processivity factor zf_C2H2_ZHX PF18387.1 ORX57490.1 - 0.12 12.1 0.1 0.34 10.6 0.1 1.8 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2 PF00096.26 ORX57490.1 - 0.32 11.5 3.0 0.86 10.2 3.0 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type LIM PF00412.22 ORX57490.1 - 0.56 10.5 5.1 8.5 6.7 0.0 2.8 3 0 0 3 3 3 0 LIM domain Mu-conotoxin PF05374.12 ORX57491.1 - 0.054 13.5 1.0 0.13 12.3 1.0 1.6 1 0 0 1 1 1 0 Mu-Conotoxin Aldo_ket_red PF00248.21 ORX57492.1 - 1.6e-51 175.2 0.1 1e-49 169.4 0.1 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family NUDIX PF00293.28 ORX57493.1 - 1e-14 54.7 0.0 1.9e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 ORX57493.1 - 2.5e-14 53.7 0.2 7.1e-14 52.3 0.4 1.7 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain Ank_4 PF13637.6 ORX57493.1 - 1.5e-09 38.2 0.2 2.8e-08 34.1 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX57493.1 - 3e-09 37.3 0.0 1.6e-07 31.8 0.0 2.6 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX57493.1 - 4.2e-06 26.9 0.2 3.2e-05 24.1 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeats (many copies) zf-NADH-PPase PF09297.11 ORX57493.1 - 4.5e-05 23.0 0.5 0.0001 21.9 0.5 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Ank_3 PF13606.6 ORX57493.1 - 0.00011 22.3 0.0 0.00091 19.5 0.0 2.7 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.30 ORX57493.1 - 0.00027 21.2 0.0 0.0046 17.3 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat BssS PF13991.6 ORX57493.1 - 0.087 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 BssS protein family DUF1843 PF08898.10 ORX57493.1 - 0.098 13.2 0.1 1.4 9.5 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) DpnI PF06044.12 ORX57493.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Dam-replacing family DNA_pol_phi PF04931.13 ORX57494.1 - 2.9e-195 650.7 21.2 4.3e-195 650.1 21.2 1.3 1 0 0 1 1 1 1 DNA polymerase phi RsbRD_N PF14361.6 ORX57494.1 - 0.025 15.3 3.8 0.61 10.8 0.2 3.9 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain TetR_C_15 PF17918.1 ORX57494.1 - 0.39 11.5 1.9 3.9 8.3 0.1 3.6 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain SDA1 PF05285.12 ORX57494.1 - 6.7 6.0 12.8 11 5.3 12.8 1.3 1 0 0 1 1 1 0 SDA1 Nramp PF01566.18 ORX57495.1 - 1.4e-105 353.2 21.4 3.4e-57 194.1 4.9 2.6 2 1 0 2 2 2 2 Natural resistance-associated macrophage protein TTL PF03133.15 ORX57496.1 - 2.2e-25 89.4 0.0 8.2e-25 87.5 0.0 1.8 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family FAD-oxidase_C PF02913.19 ORX57496.1 - 0.082 12.5 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 FAD linked oxidases, C-terminal domain DUF1682 PF07946.14 ORX57496.1 - 0.11 11.7 5.9 0.19 10.9 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Aa_trans PF01490.18 ORX57497.1 - 4.8e-59 200.1 33.8 5.5e-59 199.9 33.8 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Smg4_UPF3 PF03467.15 ORX57498.1 - 1.2e-56 191.5 0.2 1.2e-56 191.5 0.2 2.4 3 0 0 3 3 3 1 Smg-4/UPF3 family Casc1 PF12366.8 ORX57498.1 - 4.7 6.7 8.2 3.2 7.2 0.5 2.4 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 DASH_Dam1 PF08653.10 ORX57499.1 - 1.1e-12 47.6 0.3 1.9e-12 46.8 0.3 1.4 1 0 0 1 1 1 1 DASH complex subunit Dam1 MBD PF01429.19 ORX57499.1 - 0.032 13.9 0.3 0.11 12.3 0.0 2.0 2 0 0 2 2 2 0 Methyl-CpG binding domain PH PF00169.29 ORX57501.1 - 0.0004 20.8 0.0 0.00079 19.9 0.0 1.4 1 0 0 1 1 1 1 PH domain DUF2756 PF10956.8 ORX57501.1 - 0.013 15.9 0.0 0.024 15.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) Toxin_7 PF05980.12 ORX57501.1 - 0.21 11.9 0.1 0.41 10.9 0.1 1.4 1 0 0 1 1 1 0 Toxin 7 Glyco_hydro_16 PF00722.21 ORX57502.1 - 2.6e-34 118.2 1.2 3.6e-34 117.8 1.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Laminin_G_3 PF13385.6 ORX57502.1 - 0.024 14.8 0.1 0.034 14.3 0.1 1.3 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily QCR10 PF09796.9 ORX57503.1 - 4.3e-19 68.3 0.1 4.7e-19 68.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) DUF2064 PF09837.9 ORX57503.1 - 0.17 11.7 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) Sybindin PF04099.12 ORX57504.1 - 6e-52 175.4 0.7 6.7e-52 175.2 0.7 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 ORX57504.1 - 6.3e-08 32.8 0.2 7.2e-08 32.6 0.2 1.3 1 1 0 1 1 1 1 Sedlin, N-terminal conserved region L51_S25_CI-B8 PF05047.16 ORX57505.1 - 3e-13 49.4 0.1 4.8e-13 48.8 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF1147 PF06615.11 ORX57505.1 - 0.066 13.3 0.1 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) DHFR_1 PF00186.19 ORX57505.1 - 0.14 11.8 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Dihydrofolate reductase RRM_1 PF00076.22 ORX57506.1 - 2.2e-81 267.7 0.4 9.6e-18 63.8 0.0 5.8 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 ORX57506.1 - 3.9e-06 26.8 3.0 0.27 11.0 0.0 5.2 4 1 0 5 5 5 2 Rrp7 RRM-like N-terminal domain Limkain-b1 PF11608.8 ORX57506.1 - 1.2e-05 25.2 0.0 8.2 6.6 0.0 5.3 5 1 0 5 5 5 2 Limkain b1 RRM_occluded PF16842.5 ORX57506.1 - 5.6e-05 22.9 0.0 1.6 8.7 0.0 4.0 4 0 0 4 4 4 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ORX57506.1 - 5.8e-05 22.7 0.1 2.4 7.7 0.2 4.6 4 1 1 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX57506.1 - 0.00015 21.8 0.0 1.1 9.5 0.0 4.9 5 0 0 5 5 5 1 RNA recognition motif RRM_2 PF04059.12 ORX57506.1 - 0.00035 20.7 0.0 0.38 11.0 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif 2 Nup35_RRM_2 PF14605.6 ORX57506.1 - 0.0017 18.3 0.0 2.8 8.0 0.0 4.5 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Metaviral_G PF09595.10 ORX57507.1 - 0.036 14.1 3.1 0.044 13.9 3.1 1.2 1 0 0 1 1 1 0 Metaviral_G glycoprotein FAP PF07174.11 ORX57507.1 - 0.2 11.1 10.3 0.23 10.9 10.3 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) MCU PF04678.13 ORX57508.1 - 0.057 13.5 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial calcium uniporter ATP-synt_D PF01813.17 ORX57508.1 - 0.13 12.0 2.3 0.21 11.4 2.3 1.2 1 0 0 1 1 1 0 ATP synthase subunit D CP2 PF04516.15 ORX57509.1 - 1.6e-40 138.8 3.1 1e-39 136.2 3.1 1.8 1 1 0 1 1 1 1 CP2 transcription factor Edc3_linker PF16598.5 ORX57510.1 - 0.11 13.2 2.1 0.11 13.1 2.1 1.2 1 0 0 1 1 1 0 Linker region of enhancer of mRNA-decapping protein 3 DUF2009 PF09418.10 ORX57511.1 - 8.2e-193 641.6 0.2 1.1e-192 641.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 ORX57511.1 - 4.9e-05 23.4 7.8 0.00012 22.2 7.8 1.6 1 0 0 1 1 1 1 B-box zinc finger IBR PF01485.21 ORX57511.1 - 0.024 14.9 5.0 0.057 13.6 5.0 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain CEBP_ZZ PF16366.5 ORX57511.1 - 0.029 14.6 6.0 0.079 13.2 6.0 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain NOB1_Zn_bind PF08772.11 ORX57511.1 - 0.14 12.3 2.8 0.46 10.7 2.8 1.8 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Ank_2 PF12796.7 ORX57512.1 - 6.5e-26 90.7 15.1 1.1e-12 48.4 0.5 4.2 2 1 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX57512.1 - 4.4e-22 77.8 12.3 1.5e-07 31.5 0.2 4.9 4 1 1 5 5 5 5 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX57512.1 - 1.2e-18 67.2 15.7 7.2e-06 26.4 1.4 5.9 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX57512.1 - 1e-12 47.0 17.3 2.7e-05 24.2 0.1 6.7 8 0 0 8 8 8 3 Ankyrin repeat Ank PF00023.30 ORX57512.1 - 3e-10 40.1 22.2 0.0014 19.0 0.0 6.6 8 0 0 8 8 8 3 Ankyrin repeat Abhydrolase_3 PF07859.13 ORX57513.1 - 2.4e-52 177.9 0.0 3.4e-52 177.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX57513.1 - 4.3e-15 55.5 0.0 9e-15 54.4 0.0 1.3 1 1 0 1 1 1 1 Steryl acetyl hydrolase Eno-Rase_NADH_b PF12242.8 ORX57513.1 - 0.018 14.8 0.0 0.057 13.2 0.0 1.8 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase COesterase PF00135.28 ORX57513.1 - 0.031 13.2 0.0 0.21 10.4 0.0 1.9 1 1 0 1 1 1 0 Carboxylesterase family Hydrolase_4 PF12146.8 ORX57513.1 - 0.063 12.5 0.1 0.28 10.4 0.1 2.0 1 1 0 1 1 1 0 Serine aminopeptidase, S33 AXE1 PF05448.12 ORX57513.1 - 0.11 11.1 0.0 0.2 10.3 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ORX57513.1 - 0.19 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family MgtE PF01769.16 ORX57514.1 - 1.7e-45 154.4 25.2 1e-23 84.0 2.6 3.3 4 0 0 4 4 4 2 Divalent cation transporter MWFE PF15879.5 ORX57514.1 - 0.14 12.4 0.3 3.9 7.7 0.0 2.8 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit DUF4181 PF13789.6 ORX57514.1 - 0.2 11.9 3.2 5.2 7.4 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) Phage_holin_3_3 PF16083.5 ORX57514.1 - 4.9 7.3 12.4 1.4 9.1 0.4 3.9 3 1 1 4 4 4 0 LydA holin phage, holin superfamily III p450 PF00067.22 ORX57515.1 - 5.1e-74 249.7 0.1 6.8e-74 249.3 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 ER PF01133.17 ORX57516.1 - 3.3e-29 100.8 1.2 3.6e-29 100.7 1.2 1.0 1 0 0 1 1 1 1 Enhancer of rudimentary WGR PF05406.15 ORX57516.1 - 0.024 14.7 0.0 7.2 6.8 0.0 2.2 2 0 0 2 2 2 0 WGR domain RRM_1 PF00076.22 ORX57517.1 - 3.6e-37 126.0 0.0 8.8e-20 70.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX57517.1 - 1.6e-09 37.8 3.0 6.6e-08 32.6 0.2 2.7 2 0 0 2 2 2 2 Poly-adenylate binding protein, unique domain TauD PF02668.16 ORX57519.1 - 7.4e-37 127.6 1.2 1e-36 127.2 1.2 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ORX57519.1 - 7.4e-12 45.8 0.6 1.3e-11 45.0 0.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 ORX57519.1 - 0.0016 17.6 0.0 1.8 7.6 0.0 2.6 3 0 0 3 3 3 2 CsiD Amidohydro_2 PF04909.14 ORX57520.1 - 3.6e-23 82.8 3.7 4.6e-23 82.4 3.7 1.1 1 0 0 1 1 1 1 Amidohydrolase Ala_racemase_N PF01168.20 ORX57520.1 - 0.02 14.6 0.7 1.1 8.9 0.1 2.3 1 1 1 2 2 2 0 Alanine racemase, N-terminal domain Polysacc_deac_1 PF01522.21 ORX57522.1 - 1.8e-11 44.0 0.0 3.4e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Big_5 PF13205.6 ORX57522.1 - 0.04 14.6 0.3 0.16 12.6 0.1 2.1 2 0 0 2 2 2 0 Bacterial Ig-like domain YtxC PF08812.11 ORX57522.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 YtxC-like family DUF2373 PF10180.9 ORX57523.1 - 6.5e-22 77.1 0.5 1e-21 76.5 0.5 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) LRR_6 PF13516.6 ORX57524.1 - 6.7e-07 28.9 3.5 0.014 15.4 0.1 4.2 4 0 0 4 4 4 2 Leucine Rich repeat LRR_4 PF12799.7 ORX57524.1 - 0.00044 20.6 0.2 1.3 9.6 0.0 4.8 5 1 2 7 7 7 3 Leucine Rich repeats (2 copies) Peptidase_C13 PF01650.18 ORX57525.1 - 2.4e-44 151.8 1.6 2.9e-44 151.5 1.6 1.0 1 0 0 1 1 1 1 Peptidase C13 family ArgoMid PF16487.5 ORX57525.1 - 0.0039 17.4 0.6 0.011 15.9 0.0 2.0 3 0 0 3 3 3 1 Mid domain of argonaute Xan_ur_permease PF00860.20 ORX57526.1 - 3.4e-77 259.8 43.6 4.1e-77 259.5 43.6 1.1 1 0 0 1 1 1 1 Permease family Atthog PF18800.1 ORX57526.1 - 3.8 7.4 13.1 2.4 8.0 4.7 2.6 2 0 0 2 2 2 0 Attenuator of Hedgehog Ricin_B_lectin PF00652.22 ORX57527.1 - 1.5e-41 141.6 1.5 6.1e-05 23.3 0.0 10.3 7 2 2 9 9 9 9 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 ORX57527.1 - 1.1e-24 87.0 40.0 2e-06 28.4 0.2 11.9 8 4 2 11 11 11 9 Ricin-type beta-trefoil lectin domain-like DUF2500 PF10694.9 ORX57527.1 - 0.00091 19.7 1.2 8.8 6.9 0.1 6.6 4 0 0 4 4 4 1 Protein of unknown function (DUF2500) DNA_ligase_C PF17879.1 ORX57527.1 - 0.08 13.0 0.6 32 4.6 0.0 3.4 4 0 0 4 4 4 0 DNA ligase C-terminal domain Tox-REase-5 PF15648.6 ORX57527.1 - 0.1 13.1 0.0 46 4.6 0.0 3.3 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 5 ABA_WDS PF02496.16 ORX57527.1 - 0.11 13.0 427.0 2.8 8.5 8.1 30.0 30 0 0 30 30 30 0 ABA/WDS induced protein TetR_C_12 PF16914.5 ORX57527.1 - 0.88 9.7 7.8 9.7 6.4 0.7 2.9 2 0 0 2 2 2 0 Bacterial transcriptional repressor C-terminal RNA_pol_3_Rpc31 PF11705.8 ORX57527.1 - 3.4 7.9 8.6 74 3.5 8.6 3.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 F-box-like PF12937.7 ORX57528.1 - 9.3e-11 41.5 0.1 2.7e-10 40.0 0.1 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX57528.1 - 1.8e-06 27.7 1.8 1.8e-06 27.7 0.1 2.1 2 0 0 2 2 2 1 F-box domain LRR_6 PF13516.6 ORX57528.1 - 6.3e-05 22.7 3.4 3.7 7.9 0.0 5.3 5 0 0 5 5 5 2 Leucine Rich repeat F-box_4 PF15966.5 ORX57528.1 - 0.023 14.6 0.0 0.055 13.4 0.0 1.6 1 0 0 1 1 1 0 F-box Mito_carr PF00153.27 ORX57529.1 - 6e-56 186.4 0.0 6.3e-19 67.7 0.0 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein zf-C3HC4_3 PF13920.6 ORX57530.1 - 1.3e-07 31.4 7.9 1.3e-07 31.4 7.9 4.4 5 0 0 5 5 5 2 Zinc finger, C3HC4 type (RING finger) ABC_tran PF00005.27 ORX57531.1 - 2e-40 138.5 0.0 9.1e-20 71.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ORX57531.1 - 4.2e-16 59.6 5.3 7.3e-05 22.7 0.0 4.4 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX57531.1 - 9.9e-08 32.4 1.4 0.0029 17.9 0.1 3.7 2 2 1 3 3 3 2 AAA domain SMC_N PF02463.19 ORX57531.1 - 1.1e-05 25.0 0.1 0.35 10.3 0.0 3.4 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ORX57531.1 - 1.4e-05 25.1 0.0 0.028 14.5 0.0 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX57531.1 - 1.5e-05 24.6 0.0 0.0095 15.7 0.0 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX57531.1 - 2.2e-05 25.0 1.9 0.021 15.3 0.0 3.2 4 0 0 4 4 3 1 AAA domain AAA PF00004.29 ORX57531.1 - 4e-05 24.0 0.1 2.8 8.4 0.0 3.9 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ORX57531.1 - 6.1e-05 22.5 0.0 0.22 10.9 0.0 3.2 3 0 0 3 3 3 1 Bacterial TniB protein RsgA_GTPase PF03193.16 ORX57531.1 - 6.7e-05 22.9 0.0 0.23 11.3 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase IstB_IS21 PF01695.17 ORX57531.1 - 7.5e-05 22.5 0.0 3.3 7.4 0.0 3.4 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_33 PF13671.6 ORX57531.1 - 0.00011 22.4 0.1 0.6 10.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ORX57531.1 - 0.00017 21.9 0.6 0.9 9.8 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_18 PF13238.6 ORX57531.1 - 0.00022 21.8 0.0 1.2 9.7 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 ORX57531.1 - 0.00042 20.1 0.0 0.47 10.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_13 PF13166.6 ORX57531.1 - 0.0014 17.4 4.5 0.44 9.1 0.0 3.5 4 0 0 4 4 4 1 AAA domain PduV-EutP PF10662.9 ORX57531.1 - 0.0016 18.2 0.0 0.41 10.4 0.0 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ORX57531.1 - 0.0016 17.9 0.0 0.28 10.6 0.0 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.6 ORX57531.1 - 0.0018 18.3 0.0 0.39 10.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 ORX57531.1 - 0.0019 18.2 0.1 5 7.0 0.0 3.3 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea cobW PF02492.19 ORX57531.1 - 0.0024 17.5 0.0 1.8 8.1 0.0 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 ORX57531.1 - 0.0027 17.7 0.0 0.65 10.0 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 ORX57531.1 - 0.0032 16.9 0.1 1.7 8.0 0.0 2.7 3 0 0 3 3 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ORX57531.1 - 0.0053 17.0 0.0 4.4 7.6 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 ORX57531.1 - 0.0078 16.4 0.0 5.8 7.2 0.0 3.0 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Dynamin_N PF00350.23 ORX57531.1 - 0.01 15.9 0.0 0.19 11.8 0.0 2.6 2 0 0 2 2 2 0 Dynamin family AAA_16 PF13191.6 ORX57531.1 - 0.01 16.2 0.5 2.9 8.2 0.1 3.0 3 1 0 3 3 2 0 AAA ATPase domain FeoB_N PF02421.18 ORX57531.1 - 0.013 15.0 0.0 3.8 7.0 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B dNK PF01712.19 ORX57531.1 - 0.014 15.2 0.0 0.87 9.4 0.0 2.3 2 0 0 2 2 2 0 Deoxynucleoside kinase GTP_EFTU PF00009.27 ORX57531.1 - 0.017 14.7 0.0 0.15 11.6 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_15 PF13175.6 ORX57531.1 - 0.019 14.7 0.8 3.4 7.3 0.0 3.2 4 0 0 4 4 4 0 AAA ATPase domain NACHT PF05729.12 ORX57531.1 - 0.022 14.7 0.1 1.1 9.1 0.0 3.0 3 0 0 3 3 3 0 NACHT domain Ploopntkinase1 PF18748.1 ORX57531.1 - 0.026 14.1 0.0 0.086 12.4 0.0 1.8 2 0 0 2 2 1 0 P-loop Nucleotide Kinase1 NB-ARC PF00931.22 ORX57531.1 - 0.033 13.4 0.2 11 5.1 0.7 3.3 2 2 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 ORX57531.1 - 0.036 14.5 0.0 15 6.0 0.0 2.7 2 0 0 2 2 2 0 RNA helicase ATP-synt_ab PF00006.25 ORX57531.1 - 0.039 13.6 0.0 5.5 6.6 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 ORX57531.1 - 0.039 13.5 0.0 7.4 6.0 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region T2SSE PF00437.20 ORX57531.1 - 0.042 12.9 0.0 6.8 5.7 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_27 PF13514.6 ORX57531.1 - 0.075 12.6 2.7 2.4 7.7 0.0 3.2 2 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ORX57531.1 - 0.095 12.3 0.1 8.3 5.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain Rad17 PF03215.15 ORX57531.1 - 0.1 12.5 0.0 8.2 6.3 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain MobB PF03205.14 ORX57531.1 - 0.1 12.5 0.0 12 5.8 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_PrkA PF08298.11 ORX57531.1 - 0.1 11.5 0.0 0.45 9.4 0.0 1.9 2 0 0 2 2 2 0 PrkA AAA domain RuvB_N PF05496.12 ORX57531.1 - 0.11 12.3 0.0 7.2 6.3 0.0 2.4 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain SRP54 PF00448.22 ORX57531.1 - 0.11 12.1 0.0 5.1 6.7 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_17 PF13207.6 ORX57531.1 - 0.29 11.6 1.0 27 5.2 0.0 3.6 4 0 0 4 4 3 0 AAA domain AAA_30 PF13604.6 ORX57531.1 - 0.31 10.8 1.8 8.2 6.1 0.0 3.2 3 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ORX57531.1 - 0.31 10.9 0.9 42 4.0 0.0 3.2 3 0 0 3 3 3 0 NTPase CLP1_P PF16575.5 ORX57531.1 - 1 9.1 3.5 8.5 6.1 0.0 3.4 4 1 1 5 5 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Asp PF00026.23 ORX57532.1 - 1.4e-90 303.9 6.4 1.7e-90 303.6 6.4 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX57532.1 - 1e-13 51.9 8.8 2.4e-09 37.7 0.6 3.2 2 2 1 3 3 3 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX57532.1 - 0.0058 16.4 0.1 0.045 13.5 0.0 2.4 2 1 0 2 2 2 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 ORX57532.1 - 0.0073 16.9 0.3 0.24 12.1 0.0 2.7 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX57532.1 - 0.09 13.3 0.5 2.9 8.5 0.2 3.1 2 2 0 2 2 2 0 gag-polyprotein putative aspartyl protease Lipase_GDSL PF00657.22 ORX57533.1 - 5.1e-15 56.0 0.0 6.6e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX57533.1 - 9.1e-11 42.5 0.4 3.1e-10 40.7 0.4 1.9 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family AraC_N PF06719.13 ORX57533.1 - 0.13 12.0 0.0 0.34 10.6 0.0 1.7 2 0 0 2 2 2 0 AraC-type transcriptional regulator N-terminus GTP_EFTU PF00009.27 ORX57534.1 - 6.1e-17 61.8 0.3 1e-16 61.1 0.3 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ATP_bind_1 PF03029.17 ORX57534.1 - 0.0007 19.5 0.5 0.16 11.7 0.1 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein ABC_tran PF00005.27 ORX57534.1 - 0.0012 19.4 0.1 0.0024 18.4 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ORX57534.1 - 0.0012 19.2 0.0 0.0026 18.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Rad51 PF08423.11 ORX57534.1 - 0.0014 17.9 0.0 0.0028 16.9 0.0 1.4 1 0 0 1 1 1 1 Rad51 SRP54 PF00448.22 ORX57534.1 - 0.002 17.8 0.5 0.019 14.6 0.3 2.4 2 1 0 2 2 1 1 SRP54-type protein, GTPase domain NACHT PF05729.12 ORX57534.1 - 0.0023 17.8 0.1 0.0059 16.5 0.0 1.7 2 0 0 2 2 1 1 NACHT domain RsgA_GTPase PF03193.16 ORX57534.1 - 0.0024 17.8 0.4 0.067 13.1 0.1 2.6 2 1 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ORX57534.1 - 0.0036 17.4 0.0 0.0082 16.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 ORX57534.1 - 0.0048 17.1 1.2 7.3 6.8 0.1 3.2 3 0 0 3 3 3 0 AAA domain DLIC PF05783.11 ORX57534.1 - 0.012 14.5 0.1 0.28 9.9 0.1 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) T2SSE PF00437.20 ORX57534.1 - 0.013 14.6 0.1 0.03 13.4 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ORX57534.1 - 0.014 15.7 0.1 0.052 13.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ORX57534.1 - 0.014 15.4 0.1 0.035 14.2 0.0 1.8 2 0 0 2 2 1 0 Dynamin family Roc PF08477.13 ORX57534.1 - 0.014 15.6 0.2 0.14 12.4 0.1 2.3 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ORX57534.1 - 0.027 14.2 0.0 0.054 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX57534.1 - 0.027 14.2 0.2 0.11 12.2 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ORX57534.1 - 0.039 13.7 0.4 0.09 12.5 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain IIGP PF05049.13 ORX57534.1 - 0.043 12.9 0.1 0.092 11.8 0.1 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) PduV-EutP PF10662.9 ORX57534.1 - 0.055 13.2 0.7 5 6.9 0.1 2.9 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Ras PF00071.22 ORX57534.1 - 0.055 13.1 0.2 1.3 8.6 0.1 2.4 2 1 0 2 2 2 0 Ras family AAA_28 PF13521.6 ORX57534.1 - 0.056 13.7 0.2 0.13 12.5 0.2 1.6 1 0 0 1 1 1 0 AAA domain AlbA_2 PF04326.14 ORX57534.1 - 0.067 13.5 0.0 0.17 12.2 0.0 1.7 1 0 0 1 1 1 0 Putative DNA-binding domain AAA_7 PF12775.7 ORX57534.1 - 0.085 12.4 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 ORX57534.1 - 0.087 12.2 0.2 0.17 11.2 0.0 1.5 2 0 0 2 2 2 0 KaiC DAP3 PF10236.9 ORX57534.1 - 0.09 11.9 0.1 0.16 11.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 ORX57534.1 - 0.091 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain MCM PF00493.23 ORX57534.1 - 0.1 11.7 0.1 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain RNA_helicase PF00910.22 ORX57534.1 - 0.1 13.0 0.0 0.51 10.8 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Rhomboid PF01694.22 ORX57535.1 - 1.1e-20 74.1 7.6 2.3e-20 73.1 7.6 1.5 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 ORX57535.1 - 0.0081 16.7 0.2 0.018 15.6 0.2 1.7 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) RRM_1 PF00076.22 ORX57536.1 - 0.055 13.3 0.0 0.62 9.9 0.0 2.5 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CLPTM1 PF05602.12 ORX57536.1 - 0.31 10.0 3.0 0.45 9.5 3.0 1.3 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) RRM_1 PF00076.22 ORX57537.1 - 0.12 12.2 0.0 0.32 10.8 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HA2 PF04408.23 ORX57538.1 - 2.6e-25 88.8 1.4 1.8e-24 86.1 0.0 2.9 3 0 0 3 3 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX57538.1 - 3.4e-16 59.4 0.0 8.8e-16 58.0 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX57538.1 - 1e-11 45.1 0.0 5.6e-10 39.5 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX57538.1 - 1.2e-08 34.9 0.1 2.7e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX57538.1 - 3.1e-07 30.8 0.2 1.2e-06 28.8 0.0 2.1 2 0 0 2 2 1 1 AAA domain ATPase PF06745.13 ORX57538.1 - 0.00073 19.0 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 KaiC ResIII PF04851.15 ORX57538.1 - 0.0035 17.4 0.5 0.21 11.6 0.0 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 ORX57538.1 - 0.0052 15.9 0.0 0.01 14.9 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF2075 PF09848.9 ORX57538.1 - 0.016 14.5 0.0 0.034 13.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 ORX57538.1 - 0.017 15.4 0.1 0.065 13.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ORX57538.1 - 0.023 14.4 0.0 0.047 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ORX57538.1 - 0.064 12.7 0.0 0.14 11.6 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein DUF3313 PF11769.8 ORX57538.1 - 0.093 12.5 0.2 0.44 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3313) FtsK_SpoIIIE PF01580.18 ORX57538.1 - 0.11 11.9 0.0 0.48 9.7 0.0 2.0 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_33 PF13671.6 ORX57538.1 - 0.11 12.6 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX57538.1 - 2.8 8.4 15.9 0.59 10.6 2.4 3.6 3 1 0 3 3 3 0 AAA domain OrfB_Zn_ribbon PF07282.11 ORX57539.1 - 0.0001 22.1 0.5 0.0001 22.1 0.5 2.4 2 1 0 2 2 2 1 Putative transposase DNA-binding domain REV PF00424.18 ORX57539.1 - 0.4 10.7 4.8 1.1 9.3 4.8 1.7 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) zf-CCHC_6 PF15288.6 ORX57539.1 - 0.43 10.5 4.5 0.27 11.1 0.4 2.7 3 0 0 3 3 3 0 Zinc knuckle Rrn6 PF10214.9 ORX57539.1 - 0.57 8.6 4.2 1 7.8 4.2 1.3 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor LtrA PF06772.11 ORX57540.1 - 7.4e-42 143.8 25.6 7.4e-42 143.8 25.6 2.4 2 1 1 3 3 3 1 Bacterial low temperature requirement A protein (LtrA) GATA PF00320.27 ORX57541.1 - 2.8e-14 52.4 4.6 6.5e-14 51.2 4.6 1.6 1 0 0 1 1 1 1 GATA zinc finger CNDH2_C PF16858.5 ORX57541.1 - 0.0031 17.4 10.9 0.0066 16.4 10.9 1.5 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Ribosomal_S5 PF00333.20 ORX57542.1 - 7.9e-29 99.4 0.3 7.9e-29 99.4 0.3 2.0 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ORX57542.1 - 1e-25 89.0 0.0 1.8e-25 88.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 ORX57542.1 - 5.8 7.5 11.0 13 6.4 11.0 1.5 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 DUF1688 PF07958.11 ORX57543.1 - 2.7e-155 517.2 0.0 3.1e-155 517.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Q_salvage PF10343.9 ORX57543.1 - 0.15 11.6 0.0 9.3 5.7 0.0 2.4 2 1 0 2 2 2 0 Potential Queuosine, Q, salvage protein family Mcl1_mid PF12341.8 ORX57544.1 - 1.6e-84 283.8 0.0 4.3e-82 275.8 0.0 2.2 2 0 0 2 2 2 2 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 ORX57544.1 - 2.2e-20 72.6 5.1 6.6e-06 26.8 0.1 8.0 8 0 0 8 8 8 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX57544.1 - 1.1e-16 60.9 1.4 9.5e-07 29.0 0.2 7.2 3 2 5 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX57544.1 - 0.0021 18.0 0.0 0.061 13.2 0.0 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ORX57544.1 - 0.0025 17.7 0.0 0.1 12.6 0.0 3.3 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat RAB3GAP2_N PF14655.6 ORX57544.1 - 0.0041 16.4 0.0 8.3 5.5 0.0 3.7 4 1 0 4 4 4 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Frtz PF11768.8 ORX57544.1 - 0.0047 15.3 0.2 0.35 9.1 0.0 3.1 2 2 2 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 ORX57544.1 - 0.13 11.6 0.4 0.66 9.3 0.0 2.2 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ORX57544.1 - 0.15 11.1 0.1 0.57 9.2 0.0 2.0 3 0 0 3 3 3 0 VID27 C-terminal WD40-like domain Ge1_WD40 PF16529.5 ORX57544.1 - 0.16 10.9 2.4 58 2.5 0.0 4.2 4 1 1 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CCDC14 PF15254.6 ORX57545.1 - 0.017 13.9 0.3 0.022 13.5 0.3 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 DUF2387 PF09526.10 ORX57545.1 - 0.058 13.5 2.3 0.12 12.5 2.3 1.6 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) Plasmodium_Vir PF05795.11 ORX57547.1 - 0.14 11.6 0.2 0.17 11.3 0.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SAICAR_synt PF01259.18 ORX57548.1 - 9e-102 340.0 0.0 1.1e-101 339.7 0.0 1.1 1 0 0 1 1 1 1 SAICAR synthetase zf-C2H2 PF00096.26 ORX57549.1 - 0.00017 21.9 9.7 0.037 14.5 1.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX57549.1 - 0.0007 20.2 8.7 0.17 12.8 1.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX57549.1 - 0.013 15.9 0.6 0.34 11.4 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Colicin_Pyocin PF01320.18 ORX57549.1 - 0.098 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 Colicin immunity protein / pyocin immunity protein zf-C2H2_6 PF13912.6 ORX57549.1 - 0.13 12.3 7.1 6.8 6.8 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX57549.1 - 0.21 11.9 3.4 8.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX57549.1 - 0.27 11.0 7.2 0.54 10.1 0.1 2.7 2 1 0 2 2 2 0 zinc-finger C2H2-type AA_permease PF00324.21 ORX57550.1 - 2.2e-132 442.1 44.2 2.7e-132 441.8 44.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX57550.1 - 4.9e-43 147.5 48.7 6e-43 147.3 48.7 1.1 1 0 0 1 1 1 1 Amino acid permease FAT PF02259.23 ORX57551.1 - 3.7e-72 243.4 9.4 1.1e-71 241.9 9.4 1.9 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ORX57551.1 - 3e-31 109.1 0.3 1.1e-30 107.2 0.2 2.1 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ORX57551.1 - 9.6e-08 31.7 0.7 3.7e-07 29.8 0.7 2.1 1 0 0 1 1 1 1 FATC domain DUF1160 PF06648.11 ORX57551.1 - 0.0078 16.2 0.5 0.037 14.0 0.5 2.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1160) GSDH PF07995.11 ORX57551.1 - 0.047 13.0 0.0 0.084 12.2 0.0 1.3 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase DUF3385 PF11865.8 ORX57551.1 - 0.11 12.4 3.7 5.3 6.9 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF3385) RasGEF_N_2 PF14663.6 ORX57551.1 - 0.14 12.6 2.6 1 9.8 0.1 3.8 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain SDH_alpha PF03313.15 ORX57553.1 - 2.1e-103 345.5 2.7 2.7e-103 345.2 2.7 1.1 1 0 0 1 1 1 1 Serine dehydratase alpha chain SDH_beta PF03315.15 ORX57553.1 - 1.8e-58 197.3 0.0 5.5e-58 195.7 0.0 1.9 1 0 0 1 1 1 1 Serine dehydratase beta chain UCH PF00443.29 ORX57554.1 - 1.2e-27 97.0 3.0 1.2e-27 97.0 3.0 1.7 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX57554.1 - 2.5e-10 40.5 3.0 2.5e-10 40.5 3.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Phage_1_1 PF08200.11 ORX57554.1 - 0.88 10.0 4.9 3.1 8.3 4.9 2.0 1 0 0 1 1 1 0 Bacteriophage 1.1 Protein RNA_pol_Rpb4 PF03874.16 ORX57555.1 - 3.3e-20 72.6 4.7 4.8e-20 72.1 4.7 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb4 LETM1 PF07766.13 ORX57555.1 - 0.0041 16.5 0.6 0.005 16.2 0.6 1.3 1 0 0 1 1 1 1 LETM1-like protein DUF935 PF06074.12 ORX57555.1 - 0.017 13.9 0.8 0.02 13.7 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) HMMR_C PF15908.5 ORX57555.1 - 0.035 14.4 0.7 0.62 10.3 0.7 2.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal BNIP3 PF06553.12 ORX57555.1 - 0.1 12.2 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 BNIP3 Glyco_hydro_47 PF01532.20 ORX57557.1 - 6.6e-113 378.0 0.0 5.2e-59 200.4 0.0 2.5 1 1 1 2 2 2 2 Glycosyl hydrolase family 47 Glyco_hydro_127 PF07944.12 ORX57557.1 - 0.044 12.3 0.0 3.6 6.0 0.0 2.2 2 0 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 BCDHK_Adom3 PF10436.9 ORX57558.1 - 3.7e-60 202.4 0.1 5.5e-60 201.9 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX57558.1 - 9.5e-11 42.2 0.0 1.5e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX57558.1 - 6.2e-05 22.9 0.0 0.0001 22.1 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PRANC PF09372.10 ORX57558.1 - 0.16 12.3 0.2 0.47 10.8 0.2 1.8 1 0 0 1 1 1 0 PRANC domain Methyltransf_25 PF13649.6 ORX57559.1 - 1.7e-15 57.4 0.0 6.4e-15 55.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX57559.1 - 5.9e-13 49.3 0.0 1.3e-12 48.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX57559.1 - 2.3e-11 43.7 0.0 8.4e-11 41.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX57559.1 - 2.5e-10 40.1 0.0 6e-10 38.8 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ORX57559.1 - 1.1e-09 38.3 0.0 1.6e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX57559.1 - 1.9e-07 31.7 0.0 3.9e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX57559.1 - 0.00056 19.4 0.0 0.0013 18.3 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_8 PF05148.15 ORX57559.1 - 0.0059 16.5 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase DUF938 PF06080.12 ORX57559.1 - 0.045 13.5 0.0 0.61 9.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF938) FtsJ PF01728.19 ORX57559.1 - 0.061 13.4 0.0 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_29 PF03141.16 ORX57559.1 - 0.11 11.1 0.0 0.32 9.5 0.0 1.6 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_2 PF00891.18 ORX57559.1 - 0.15 11.4 0.0 0.29 10.4 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase domain UQ_con PF00179.26 ORX57560.1 - 3.7e-22 78.5 0.1 4.5e-22 78.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX57560.1 - 0.07 12.8 0.0 0.086 12.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B HNH_3 PF13392.6 ORX57562.1 - 7.4e-22 76.8 0.9 9.4e-11 41.3 0.0 2.6 2 0 0 2 2 2 2 HNH endonuclease NUMOD4 PF07463.11 ORX57562.1 - 0.00051 20.2 0.0 0.00097 19.3 0.0 1.4 1 0 0 1 1 1 1 NUMOD4 motif DUF3558 PF12079.8 ORX57562.1 - 0.0051 16.8 0.1 0.0079 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3558) Aminotran_4 PF01063.19 ORX57563.1 - 5e-34 118.1 0.0 6.2e-34 117.8 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Rad52_Rad22 PF04098.15 ORX57564.1 - 2.8e-50 170.2 0.0 3.5e-50 169.9 0.0 1.0 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Arrestin_N PF00339.29 ORX57566.1 - 5.2e-06 26.6 0.0 1.4e-05 25.2 0.0 1.8 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX57566.1 - 6.1e-05 23.5 6.0 9.6e-05 22.8 1.3 3.1 2 2 1 3 3 3 1 Arrestin (or S-antigen), C-terminal domain LDB19 PF13002.7 ORX57566.1 - 0.0077 15.9 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 Arrestin_N terminal like TPR_9 PF13371.6 ORX57567.1 - 6.7e-21 74.2 6.9 6.5e-07 29.4 0.0 5.0 3 2 2 5 5 5 5 Tetratricopeptide repeat DnaJ PF00226.31 ORX57567.1 - 1.1e-20 73.5 3.0 1.1e-20 73.5 3.0 2.8 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 ORX57567.1 - 4.7e-19 67.3 10.8 3.6e-06 26.6 0.0 7.4 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX57567.1 - 4.6e-18 63.8 11.6 0.0054 16.7 0.0 8.1 7 2 1 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX57567.1 - 1.9e-16 60.4 12.8 3.8e-08 33.9 0.2 4.8 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX57567.1 - 3.7e-14 53.0 17.2 2.6e-06 27.8 0.3 5.8 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX57567.1 - 5.1e-13 48.1 5.8 0.00042 20.3 0.0 6.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX57567.1 - 1.7e-12 46.8 8.6 2.8e-05 24.2 0.1 5.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX57567.1 - 1.3e-11 44.0 15.3 8.5e-06 25.4 0.5 6.5 5 2 2 7 7 7 3 TPR repeat TPR_14 PF13428.6 ORX57567.1 - 5.1e-09 36.2 13.3 0.15 13.0 0.1 6.9 3 1 4 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX57567.1 - 1.6e-07 31.5 12.6 0.00059 20.3 0.1 5.9 4 1 1 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX57567.1 - 0.00013 22.1 13.3 0.035 14.3 1.2 5.0 3 3 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX57567.1 - 0.00093 19.1 6.6 2.4 8.4 0.1 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX57567.1 - 0.001 19.4 12.6 0.035 14.4 0.0 5.1 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX57567.1 - 0.0042 17.3 13.5 0.22 11.8 0.3 5.5 3 3 2 5 5 5 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ORX57567.1 - 0.012 15.3 0.1 1.3 8.7 0.2 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_4 PF07721.14 ORX57567.1 - 0.018 15.6 1.4 1.2 10.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX57567.1 - 0.16 12.1 7.0 3 8.0 0.0 5.2 5 2 1 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat Thioredoxin_8 PF13905.6 ORX57567.1 - 0.23 11.8 3.3 0.18 12.1 0.4 2.1 2 0 0 2 2 2 0 Thioredoxin-like TPR_21 PF09976.9 ORX57567.1 - 1.8 8.3 18.3 0.092 12.4 0.3 4.6 2 2 3 5 5 5 0 Tetratricopeptide repeat-like domain TMEM18 PF14770.6 ORX57568.1 - 1.2e-34 118.8 5.3 1.4e-34 118.6 5.3 1.0 1 0 0 1 1 1 1 Transmembrane protein 18 TMEM189_B_dmain PF10520.9 ORX57568.1 - 0.0088 16.2 0.3 0.012 15.7 0.3 1.2 1 0 0 1 1 1 1 B domain of TMEM189, localisation domain DUF979 PF06166.12 ORX57568.1 - 0.0093 15.2 0.1 0.015 14.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF979) FtsX PF02687.21 ORX57568.1 - 0.55 10.7 5.3 1.4 9.4 5.3 1.8 1 1 1 2 2 2 0 FtsX-like permease family DUF4131 PF13567.6 ORX57568.1 - 4.7 6.8 8.4 4.8 6.8 7.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) CAP PF00188.26 ORX57569.1 - 1.6e-20 74.2 7.8 1.6e-20 74.2 7.8 2.4 2 1 0 2 2 2 1 Cysteine-rich secretory protein family DUF2457 PF10446.9 ORX57569.1 - 0.0071 15.5 10.8 0.0088 15.2 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Metal_resist PF13801.6 ORX57569.1 - 0.035 14.3 4.7 0.39 10.9 0.3 2.2 1 1 1 2 2 2 0 Heavy-metal resistance EBP50_C PF09007.11 ORX57569.1 - 0.042 14.8 11.2 0.063 14.3 11.2 1.2 1 0 0 1 1 1 0 EBP50, C-terminal FAM76 PF16046.5 ORX57569.1 - 0.055 12.8 4.4 0.074 12.4 4.4 1.2 1 0 0 1 1 1 0 FAM76 protein Conotoxin PF02950.17 ORX57569.1 - 0.09 13.8 0.6 0.23 12.5 0.3 2.0 1 1 1 2 2 2 0 Conotoxin DUF4834 PF16118.5 ORX57569.1 - 0.1 13.5 0.0 0.22 12.5 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Ndc1_Nup PF09531.10 ORX57569.1 - 0.14 10.8 2.8 0.16 10.7 2.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.22 ORX57569.1 - 0.18 11.0 5.4 0.2 10.8 5.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ORX57569.1 - 0.19 11.7 2.4 0.26 11.3 2.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ctr PF04145.15 ORX57569.1 - 0.21 12.2 1.9 0.24 12.0 1.0 1.5 1 1 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 ORX57569.1 - 0.36 9.5 0.6 0.32 9.7 0.6 1.2 1 0 0 1 1 1 0 Presenilin ASD2 PF08687.11 ORX57569.1 - 0.65 9.5 2.9 0.85 9.1 2.9 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SelP_N PF04592.14 ORX57569.1 - 3.1 7.1 18.0 4.9 6.5 18.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region UPF0160 PF03690.13 ORX57570.1 - 1.4e-132 442.2 0.0 1.6e-132 442.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) SAP PF02037.27 ORX57571.1 - 1.3e-10 40.8 0.2 2.1e-10 40.1 0.2 1.3 1 0 0 1 1 1 1 SAP domain SRF-TF PF00319.18 ORX57573.1 - 5.7e-25 86.6 0.0 7.4e-25 86.2 0.0 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) FGGY_C PF02782.16 ORX57574.1 - 1.1e-65 221.1 0.4 1.6e-65 220.6 0.4 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ORX57574.1 - 1.2e-48 165.9 0.4 3.3e-48 164.4 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, N-terminal domain Peptidase_S10 PF00450.22 ORX57575.1 - 1.9e-109 366.9 4.5 2.3e-109 366.6 4.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase SQS_PSY PF00494.19 ORX57576.1 - 2.4e-38 132.2 0.0 2.8e-38 131.9 0.0 1.0 1 0 0 1 1 1 1 Squalene/phytoene synthase Zn_clus PF00172.18 ORX57577.1 - 5.5e-05 23.2 13.3 0.0001 22.3 13.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CNH PF00780.22 ORX57578.1 - 3.8e-47 161.2 0.0 5.9e-47 160.6 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX57578.1 - 8.4e-33 114.1 0.3 1.6e-32 113.2 0.3 1.5 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX57578.1 - 2.3e-29 102.2 0.0 5.2e-29 101.1 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ORX57578.1 - 9.9e-11 41.6 0.0 2e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Citrate_bind PF16114.5 ORX57579.1 - 5.1e-89 296.5 0.0 9.6e-89 295.6 0.0 1.5 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding Citrate_synt PF00285.21 ORX57579.1 - 1.4e-17 63.8 0.0 1.2e-15 57.4 0.0 2.9 2 1 1 3 3 3 1 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 ORX57579.1 - 5.8e-17 61.9 0.1 1.4e-16 60.7 0.1 1.7 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ORX57579.1 - 1.2e-11 45.1 0.0 2.7e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 ORX57579.1 - 1.2e-10 41.3 0.0 2.2e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 ORX57579.1 - 1.5e-06 28.0 0.0 7.2e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain zf-C2H2 PF00096.26 ORX57580.1 - 3.4e-11 42.9 18.2 2.2e-05 24.7 7.2 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX57580.1 - 1.3e-07 31.9 15.4 0.00023 21.7 2.3 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX57580.1 - 4.4e-06 26.9 15.5 5e-06 26.7 4.7 3.1 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX57580.1 - 0.0011 19.2 6.0 0.043 14.1 1.0 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX57580.1 - 0.0015 19.1 4.3 0.014 16.0 0.4 2.0 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX57580.1 - 0.0032 17.4 1.0 0.0032 17.4 1.0 3.0 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX57580.1 - 0.0052 16.9 2.8 1.4 9.0 0.2 2.0 2 0 0 2 2 2 2 Aberrant zinc-finger Ogr_Delta PF04606.12 ORX57580.1 - 0.0065 16.4 1.7 0.14 12.2 0.1 2.1 1 1 1 2 2 2 1 Ogr/Delta-like zinc finger zf-H2C2_5 PF13909.6 ORX57580.1 - 0.0083 15.9 10.9 0.33 10.8 0.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc-finger domain zf-met PF12874.7 ORX57580.1 - 0.046 14.1 10.5 0.81 10.2 1.9 2.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-LYAR PF08790.11 ORX57580.1 - 0.075 12.9 2.6 1.9 8.5 0.7 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.7 ORX57580.1 - 0.38 11.1 7.8 2.6 8.4 1.6 2.0 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) TRAF6_Z2 PF18048.1 ORX57580.1 - 1.9 8.7 9.7 0.23 11.6 1.4 2.8 2 1 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2 PF00096.26 ORX57581.1 - 6.8e-12 45.2 15.6 4.4e-06 26.9 4.0 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX57581.1 - 3.4e-08 33.5 1.9 3.4e-08 33.5 1.9 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX57581.1 - 1.1e-05 25.8 12.8 0.0027 18.4 3.3 2.5 3 0 0 3 3 3 2 C2H2-type zinc finger Ogr_Delta PF04606.12 ORX57581.1 - 0.0036 17.3 0.1 0.64 10.0 0.0 2.3 1 1 1 2 2 2 2 Ogr/Delta-like zinc finger FOXP-CC PF16159.5 ORX57581.1 - 0.012 16.3 4.9 0.56 10.9 0.8 2.1 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 ORX57581.1 - 0.12 12.5 2.3 0.24 11.5 2.3 1.4 1 1 0 1 1 1 0 Aberrant zinc-finger zf-LYAR PF08790.11 ORX57581.1 - 0.39 10.7 3.9 0.44 10.5 1.0 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger PTPLA PF04387.14 ORX57583.1 - 1.5e-11 44.3 1.7 1.5e-11 44.3 1.7 1.8 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Pkinase PF00069.25 ORX57584.1 - 0.00052 19.5 0.0 0.00079 18.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain GAT PF03127.14 ORX57584.1 - 0.093 13.1 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 GAT domain Pkinase PF00069.25 ORX57585.1 - 1.9e-32 112.7 0.0 2.5e-32 112.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX57585.1 - 4.6e-16 58.9 0.0 6.3e-16 58.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX57585.1 - 3.1e-05 23.4 0.0 4.8e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX57585.1 - 0.0035 16.7 0.0 0.0091 15.3 0.0 1.7 1 1 0 1 1 1 1 Kinase-like CN_hydrolase PF00795.22 ORX57586.1 - 6.6e-59 199.4 0.0 7.6e-59 199.2 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Ribosom_S12_S23 PF00164.25 ORX57588.1 - 5.4e-52 174.2 0.8 6.8e-52 173.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 VWA_2 PF13519.6 ORX57589.1 - 8.7e-27 93.9 1.0 5.6e-26 91.3 0.1 2.7 3 0 0 3 3 3 1 von Willebrand factor type A domain Ssl1 PF04056.14 ORX57589.1 - 2.5e-08 34.0 1.7 1.3e-07 31.6 0.1 2.3 2 1 0 2 2 2 1 Ssl1-like UIM PF02809.20 ORX57589.1 - 2.2e-05 24.0 13.5 0.00016 21.3 3.0 5.3 7 0 0 7 7 7 3 Ubiquitin interaction motif DUF4362 PF14275.6 ORX57589.1 - 0.018 15.3 0.4 0.058 13.7 0.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4362) YjeF_N PF03853.15 ORX57589.1 - 0.082 12.8 0.1 13 5.6 0.0 2.5 2 0 0 2 2 2 0 YjeF-related protein N-terminus AKAP7_RIRII_bdg PF10470.9 ORX57589.1 - 1.3 9.1 6.5 0.76 9.9 0.1 3.2 3 0 0 3 3 3 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein AA_permease PF00324.21 ORX57590.1 - 3.3e-122 408.5 42.4 4.1e-122 408.2 42.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX57590.1 - 1.1e-32 113.4 44.6 1.4e-32 113.1 44.6 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1290 PF06947.12 ORX57590.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1290) Methyltransf_25 PF13649.6 ORX57591.1 - 4.1e-16 59.5 0.0 3.2e-15 56.6 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX57591.1 - 1.4e-14 54.5 0.0 5.1e-14 52.7 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX57591.1 - 1.6e-14 54.1 0.0 3.4e-14 53.0 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX57591.1 - 2.2e-12 47.0 0.0 3.3e-11 43.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX57591.1 - 4.5e-09 36.9 0.0 2.5e-08 34.6 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX57591.1 - 2.4e-06 27.0 0.0 2.1e-05 24.0 0.0 2.4 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ORX57591.1 - 5.1e-06 26.7 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_4 PF02390.17 ORX57591.1 - 0.00012 21.6 0.0 0.00046 19.7 0.0 1.8 2 0 0 2 2 2 1 Putative methyltransferase CMAS PF02353.20 ORX57591.1 - 0.00021 20.7 0.0 0.0005 19.5 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 ORX57591.1 - 0.0017 17.9 0.0 0.0079 15.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ORX57591.1 - 0.002 18.0 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase MetW PF07021.12 ORX57591.1 - 0.021 14.4 0.0 0.059 13.0 0.0 1.6 1 1 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 ORX57591.1 - 0.038 13.3 0.0 0.06 12.6 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_29 PF03141.16 ORX57591.1 - 0.081 11.5 0.0 0.24 9.9 0.0 1.6 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PrmA PF06325.13 ORX57591.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) B12-binding PF02310.19 ORX57591.1 - 0.16 12.0 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 B12 binding domain PCMT PF01135.19 ORX57591.1 - 0.21 11.3 0.0 0.38 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) YgaB PF14182.6 ORX57592.1 - 1.2 9.6 4.7 2.1 8.8 4.7 1.2 1 0 0 1 1 1 0 YgaB-like protein ATP-synt_ab PF00006.25 ORX57593.1 - 1e-63 214.8 0.0 1.9e-63 214.0 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX57593.1 - 1.3e-23 83.3 2.3 3.6e-23 81.9 2.0 2.0 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain NACHT PF05729.12 ORX57593.1 - 0.0078 16.1 0.1 0.018 14.9 0.0 1.6 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ORX57593.1 - 0.011 15.0 1.0 0.014 14.5 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ORX57593.1 - 0.016 15.1 0.0 0.031 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ORX57593.1 - 0.02 15.3 0.1 0.072 13.5 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX57593.1 - 0.021 15.3 0.0 0.32 11.4 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ORX57593.1 - 0.026 14.4 0.0 0.068 13.1 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 ORX57593.1 - 0.033 13.5 0.1 0.063 12.6 0.1 1.5 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 ORX57593.1 - 0.049 13.5 0.7 0.34 10.8 0.7 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 ORX57593.1 - 0.07 13.5 0.7 0.28 11.5 0.2 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX57593.1 - 0.12 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ORX57593.1 - 0.2 11.1 0.0 0.5 9.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PPR_2 PF13041.6 ORX57594.1 - 3e-54 181.0 7.4 7.7e-12 45.2 0.0 7.8 4 1 4 8 8 8 7 PPR repeat family PPR_3 PF13812.6 ORX57594.1 - 2.4e-32 110.8 1.1 3.8e-11 42.9 0.0 5.6 4 1 1 5 5 5 5 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX57594.1 - 1.6e-31 107.7 0.1 1.9e-08 33.9 0.0 6.9 7 0 0 7 7 7 5 PPR repeat PPR PF01535.20 ORX57594.1 - 5.1e-31 104.7 4.7 1.1e-05 25.3 0.1 8.1 8 0 0 8 8 8 6 PPR repeat PPR_long PF17177.4 ORX57594.1 - 6.4e-18 64.9 1.0 6.1e-06 25.8 0.0 3.4 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 ORX57594.1 - 0.00036 20.9 0.6 12 6.3 0.0 5.2 3 2 3 6 6 6 1 Mitochondrial ribonuclease P subunit (RPM2) SNF PF00209.18 ORX57594.1 - 0.0076 15.0 0.1 0.011 14.5 0.1 1.1 1 0 0 1 1 1 1 Sodium:neurotransmitter symporter family TPR_14 PF13428.6 ORX57594.1 - 0.024 15.5 0.0 4.5 8.3 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat BKACE PF05853.12 ORX57594.1 - 0.076 12.3 2.3 14 4.9 0.1 3.2 2 1 1 3 3 3 0 beta-keto acid cleavage enzyme UCR_UQCRX_QCR9 PF05365.12 ORX57594.1 - 0.15 12.0 0.0 0.58 10.1 0.0 2.0 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like Exog_C PF18026.1 ORX57594.1 - 0.18 11.9 0.0 12 6.0 0.0 3.4 4 0 0 4 4 4 0 Endo/exonuclease (EXOG) C-terminal domain Inhibitor_I78 PF11720.8 ORX57595.1 - 4.1e-07 30.0 0.0 5e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 ORX57595.1 - 0.00039 21.0 0.2 0.0027 18.3 0.1 1.9 1 1 1 2 2 2 1 Potato inhibitor I family DUF1748 PF08520.10 ORX57596.1 - 3e-28 97.5 0.0 3.4e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) DUF1072 PF06380.11 ORX57596.1 - 0.093 12.6 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1072) ABC1 PF03109.16 ORX57597.1 - 5.1e-30 104.1 0.0 8.2e-30 103.4 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 ORX57597.1 - 0.0003 20.2 0.0 0.0045 16.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 ORX57597.1 - 0.00042 20.0 0.1 0.0025 17.5 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 ORX57597.1 - 0.024 14.5 3.5 0.14 12.0 0.1 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family MIF4G_like PF09088.11 ORX57597.1 - 0.053 13.3 1.4 0.094 12.5 1.4 1.3 1 0 0 1 1 1 0 MIF4G like Corona_5a PF06336.11 ORX57597.1 - 0.57 10.2 0.0 0.57 10.2 0.0 2.3 3 0 0 3 3 3 0 Coronavirus 5a protein RRP36 PF06102.12 ORX57598.1 - 4.1e-49 166.7 32.9 4.1e-49 166.7 32.9 2.1 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Chi-conotoxin PF16981.5 ORX57598.1 - 0.19 12.0 1.0 0.56 10.5 0.1 2.3 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily FOG_N PF15888.5 ORX57598.1 - 3 8.3 7.2 11 6.4 3.2 2.5 2 1 0 2 2 2 0 Folded gastrulation N-terminus Glyco_hydro_18 PF00704.28 ORX57599.1 - 8.3e-70 236.0 7.6 1e-69 235.6 7.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Fungal_trans PF04082.18 ORX57600.1 - 3.1e-13 49.4 0.0 1.4e-12 47.2 0.0 2.0 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX57600.1 - 3.1e-09 36.8 11.2 6.1e-09 35.9 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SAE2 PF08573.10 ORX57602.1 - 0.032 15.4 0.1 0.032 15.4 0.1 2.6 2 1 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus UPF0242 PF06785.11 ORX57602.1 - 0.33 11.0 5.4 1.1 9.4 5.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1947 PF09183.10 ORX57602.1 - 0.85 10.0 8.2 1.4 9.3 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) Trehalase PF01204.18 ORX57603.1 - 1.8e-170 568.2 0.2 2.9e-170 567.5 0.2 1.3 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 ORX57603.1 - 3.7e-13 48.9 1.3 7.5e-13 47.9 1.3 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain CRAL_TRIO PF00650.20 ORX57604.1 - 8.3e-39 132.9 0.4 1.2e-38 132.3 0.4 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX57604.1 - 9.3e-11 41.8 0.0 2.4e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX57604.1 - 1.4e-07 31.7 0.3 2.4e-07 31.0 0.3 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain ACC_central PF08326.12 ORX57605.1 - 8.5e-254 844.2 0.7 1.1e-253 843.8 0.7 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 ORX57605.1 - 4.5e-175 583.0 0.0 6e-175 582.6 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 ORX57605.1 - 7.3e-52 175.9 0.0 1.5e-51 174.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ORX57605.1 - 1.4e-29 102.8 0.1 3.6e-29 101.5 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX57605.1 - 4.1e-23 81.5 0.0 5.2e-21 74.8 0.0 3.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ORX57605.1 - 3.8e-15 55.5 0.0 9.5e-15 54.2 0.0 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 ORX57605.1 - 0.00026 21.1 0.0 0.00081 19.5 0.0 1.9 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ORX57605.1 - 0.01 15.4 0.0 0.027 14.0 0.0 1.7 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX57605.1 - 0.011 15.3 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain Gp-FAR-1 PF05823.12 ORX57605.1 - 0.017 15.5 0.7 0.081 13.3 0.0 2.4 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) ATPgrasp_Ter PF15632.6 ORX57605.1 - 0.055 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Biotin_lipoyl_2 PF13533.6 ORX57605.1 - 0.062 13.1 0.0 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 Biotin-lipoyl like DUF4974 PF16344.5 ORX57605.1 - 3 7.9 5.3 1.5 8.9 0.9 2.7 3 0 0 3 3 2 0 Domain of unknown function (DUF4974) zf-C2H2 PF00096.26 ORX57606.1 - 0.2 12.2 4.1 0.6 10.7 4.1 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type TFIIA PF03153.13 ORX57606.1 - 1.1 9.2 14.7 1.5 8.8 14.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf-C3HC4_3 PF13920.6 ORX57607.1 - 7.7e-09 35.3 4.9 1.4e-08 34.5 4.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 ORX57607.1 - 1.2e-07 31.4 1.4 2.5e-07 30.4 1.4 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_2 PF13923.6 ORX57607.1 - 6.1e-07 29.2 6.6 1.2e-06 28.3 6.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX57607.1 - 2.7e-06 27.3 7.2 6.5e-06 26.1 7.2 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX57607.1 - 5.4e-06 26.3 8.6 9.9e-06 25.4 8.6 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX57607.1 - 5.6e-06 26.1 8.9 1.1e-05 25.2 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 ORX57607.1 - 2e-05 24.5 2.6 4.1e-05 23.5 2.6 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-RING_2 PF13639.6 ORX57607.1 - 2.8e-05 24.4 6.7 5.2e-05 23.5 6.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 ORX57607.1 - 0.00027 21.0 7.2 0.00071 19.7 7.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 ORX57607.1 - 0.00051 20.1 2.2 0.00051 20.1 2.2 1.8 2 0 0 2 2 1 1 zinc RING finger of MSL2 zf-RanBP PF00641.18 ORX57607.1 - 0.0016 17.7 4.2 0.0016 17.7 4.2 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-CCCH_4 PF18044.1 ORX57607.1 - 0.0029 17.4 1.8 0.0029 17.4 1.8 1.7 2 0 0 2 2 1 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 ORX57607.1 - 0.007 16.2 6.2 0.013 15.3 6.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ORX57607.1 - 0.025 14.4 1.4 0.068 13.0 1.4 1.7 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 ORX57607.1 - 6.7 7.1 7.6 76 3.7 0.2 2.5 1 1 1 2 2 2 0 RING-H2 zinc finger domain GPR_Gpa2_C PF11970.8 ORX57608.1 - 0.012 15.7 1.0 0.059 13.4 1.0 2.2 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term cwf18 PF08315.12 ORX57609.1 - 4.9e-35 121.1 8.9 7.6e-35 120.5 8.9 1.3 1 0 0 1 1 1 1 cwf18 pre-mRNA splicing factor SIR4_SID PF16991.5 ORX57609.1 - 0.0023 18.0 0.3 0.0029 17.7 0.3 1.2 1 0 0 1 1 1 1 Sir4 SID domain Noelin-1 PF12308.8 ORX57609.1 - 0.036 14.1 1.1 0.064 13.2 1.1 1.4 1 0 0 1 1 1 0 Neurogenesis glycoprotein TAN PF11640.8 ORX57609.1 - 0.28 11.3 2.7 2.7 8.1 2.7 2.3 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair BBS1 PF14779.6 ORX57610.1 - 0.19 11.1 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 1 SNARE_assoc PF09335.11 ORX57611.1 - 2.1e-20 73.4 5.4 4.3e-20 72.4 5.4 1.6 1 0 0 1 1 1 1 SNARE associated Golgi protein DUF4717 PF15838.5 ORX57612.1 - 0.0083 16.1 0.8 0.074 13.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4717) SNARE_assoc PF09335.11 ORX57613.1 - 2.3e-17 63.6 6.6 2.3e-17 63.6 6.6 2.0 2 0 0 2 2 2 1 SNARE associated Golgi protein Thioredoxin PF00085.20 ORX57614.1 - 1e-08 35.1 0.1 6.4e-08 32.5 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin UPF0113_N PF17833.1 ORX57615.1 - 2.2e-31 108.3 0.0 3.5e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 ORX57615.1 - 9.7e-26 89.9 0.0 1.5e-25 89.2 0.0 1.3 1 0 0 1 1 1 1 UPF0113 PUA domain PUA PF01472.20 ORX57615.1 - 0.02 14.9 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 PUA domain NAC PF01849.18 ORX57618.1 - 5e-20 71.2 0.5 3.1e-19 68.7 0.1 2.1 2 0 0 2 2 2 1 NAC domain PGA2 PF07543.12 ORX57618.1 - 6.5 6.7 8.6 0.35 10.8 3.5 1.5 2 0 0 2 2 2 0 Protein trafficking PGA2 NAT PF04768.13 ORX57619.1 - 1.8e-43 148.2 0.1 3.7e-43 147.1 0.1 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Peptidase_S37 PF05576.11 ORX57619.1 - 0.077 11.7 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 Paired_CXXCH_1 PF09699.10 ORX57620.1 - 0.47 10.2 7.1 18 5.1 0.3 3.2 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) CxC1 PF18802.1 ORX57621.1 - 0.074 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 CxC1 like cysteine cluster associated with KDZ transposases FGGY_C PF02782.16 ORX57622.1 - 9.5e-26 90.7 0.0 2.9e-25 89.2 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ORX57622.1 - 3.4e-16 59.6 0.4 5e-14 52.5 0.4 2.6 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Ras PF00071.22 ORX57623.1 - 8.3e-55 184.8 0.0 1.2e-54 184.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX57623.1 - 3.3e-35 120.9 0.0 4.8e-35 120.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX57623.1 - 4.1e-17 62.2 0.1 5.9e-17 61.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX57623.1 - 4.3e-05 23.0 0.1 5.6e-05 22.6 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ORX57623.1 - 0.00012 21.6 0.0 0.00021 20.8 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ORX57623.1 - 0.0012 18.8 0.0 0.77 9.6 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 ORX57623.1 - 0.003 17.6 0.0 0.0044 17.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ORX57623.1 - 0.0083 15.7 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region FeoB_N PF02421.18 ORX57623.1 - 0.02 14.4 0.1 2.9 7.4 0.1 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 ORX57623.1 - 0.085 12.6 0.1 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain TetR_C_16 PF17920.1 ORX57623.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain FKBP_C PF00254.28 ORX57624.1 - 1.6e-32 111.7 0.0 6.8e-32 109.7 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 ORX57624.1 - 7.8e-17 61.8 0.0 7.8e-17 61.8 0.0 3.2 2 1 0 2 2 1 1 Nucleoplasmin-like domain Velvet PF11754.8 ORX57624.1 - 0.18 11.7 7.3 0.3 11.0 7.3 1.4 1 0 0 1 1 1 0 Velvet factor SLC12 PF03522.15 ORX57624.1 - 0.19 10.8 21.9 0.25 10.3 21.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 MMR1 PF08505.10 ORX57624.1 - 0.75 10.0 22.3 1.1 9.4 22.3 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein GREB1 PF15782.5 ORX57624.1 - 1.1 6.2 22.2 1.4 5.9 22.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 ORX57624.1 - 1.3 9.0 15.2 1.7 8.7 15.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 ORX57624.1 - 3.2 5.6 19.4 4.9 4.9 19.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Band_3_cyto PF07565.13 ORX57624.1 - 3.5 7.4 18.6 5.7 6.6 18.6 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SOBP PF15279.6 ORX57624.1 - 5.1 7.6 16.2 7.1 7.1 16.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein CCSAP PF15748.5 ORX57624.1 - 5.7 7.0 35.2 9.1 6.4 35.2 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CCDC71L PF15374.6 ORX57624.1 - 6.6 5.9 24.8 9.3 5.4 24.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L MAJIN PF15077.6 ORX57624.1 - 7.6 6.2 20.3 13 5.5 20.3 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein PMT PF02366.18 ORX57625.1 - 1.3e-89 300.0 17.1 1.3e-89 300.0 17.1 2.2 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 ORX57625.1 - 1.1e-63 214.5 13.8 1.1e-63 214.5 13.8 2.1 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 ORX57625.1 - 3.2e-31 108.6 1.5 5.9e-31 107.8 1.5 1.3 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 ORX57625.1 - 4.2e-06 27.1 9.7 4.2e-06 27.1 9.7 3.3 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Cation_efflux PF01545.21 ORX57626.1 - 5.6e-50 169.9 9.5 7e-50 169.5 9.5 1.1 1 0 0 1 1 1 1 Cation efflux family DUF4131 PF13567.6 ORX57626.1 - 3.8 7.1 4.9 9.5 5.8 0.0 3.3 4 1 0 4 4 4 0 Domain of unknown function (DUF4131) Abp2 PF09441.10 ORX57628.1 - 4.8e-21 75.6 0.0 1.1e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 ARS binding protein 2 FliD_C PF07195.12 ORX57628.1 - 0.065 12.6 0.6 0.14 11.6 0.6 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Cnn_1N PF07989.11 ORX57628.1 - 0.71 10.1 4.2 0.84 9.8 0.7 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Prefoldin_2 PF01920.20 ORX57628.1 - 0.86 9.6 4.9 0.83 9.6 1.5 2.4 2 0 0 2 2 2 0 Prefoldin subunit FlxA PF14282.6 ORX57628.1 - 3.6 7.6 7.8 0.27 11.2 1.0 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF2675 PF11247.8 ORX57630.1 - 0.074 13.2 0.1 0.19 11.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2675) OrfB_Zn_ribbon PF07282.11 ORX57632.1 - 3.1e-11 43.0 0.7 4.5e-11 42.5 0.7 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Phage_lysozyme PF00959.19 ORX57632.1 - 0.1 13.0 0.0 0.42 11.1 0.0 1.9 3 0 0 3 3 3 0 Phage lysozyme RNA_POL_M_15KD PF02150.16 ORX57632.1 - 0.56 10.1 2.7 4.4 7.3 2.7 2.1 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit AAA_11 PF13086.6 ORX57635.1 - 1.1e-69 235.2 1.9 2.2e-69 234.2 1.9 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ORX57635.1 - 2.2e-60 203.7 0.0 5.5e-60 202.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain SEN1_N PF12726.7 ORX57635.1 - 4.4e-28 98.0 19.6 1.5e-23 83.0 8.5 2.2 2 0 0 2 2 2 2 SEN1 N terminal AAA_30 PF13604.6 ORX57635.1 - 3.6e-11 43.1 0.1 1.7e-07 31.1 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_19 PF13245.6 ORX57635.1 - 8.3e-09 35.9 0.5 9e-08 32.6 0.5 2.4 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ORX57635.1 - 0.00012 21.7 5.1 0.00013 21.6 1.6 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 ORX57635.1 - 0.00014 21.7 0.2 0.26 11.0 0.0 3.3 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 ORX57635.1 - 0.00018 21.1 0.0 0.00049 19.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 ORX57635.1 - 0.0011 18.7 0.2 0.0036 17.1 0.2 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_RecD PF05127.14 ORX57635.1 - 0.0013 18.6 0.1 0.033 14.0 0.0 2.6 2 0 0 2 2 2 1 Helicase AAA_22 PF13401.6 ORX57635.1 - 0.0062 16.8 0.4 0.042 14.1 0.1 2.4 1 1 0 2 2 2 1 AAA domain ResIII PF04851.15 ORX57635.1 - 0.018 15.0 0.0 0.085 12.9 0.0 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA PF00004.29 ORX57635.1 - 0.044 14.2 0.3 1.5 9.2 0.1 3.3 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ORX57635.1 - 0.093 12.7 0.5 1.8 8.6 0.1 2.8 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 ORX57635.1 - 0.11 11.6 0.8 0.4 9.7 0.1 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF745 PF05335.13 ORX57635.1 - 1.2 8.8 3.8 3.6 7.3 3.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF745) TANGO2 PF05742.12 ORX57639.1 - 2.4e-40 139.2 0.1 4e-23 82.8 0.0 2.4 1 1 1 2 2 2 2 Transport and Golgi organisation 2 Mito_carr PF00153.27 ORX57640.1 - 1.5e-44 149.9 0.3 5.8e-23 80.6 0.1 2.9 2 1 0 2 2 2 2 Mitochondrial carrier protein MFS_1 PF07690.16 ORX57641.1 - 1.8e-53 181.8 47.2 2.6e-44 151.6 22.4 2.7 1 1 2 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX57641.1 - 3.3e-11 42.7 20.9 4.3e-11 42.3 5.4 3.3 1 1 2 3 3 3 2 Sugar (and other) transporter MFS_1_like PF12832.7 ORX57641.1 - 5.2e-08 32.1 16.9 0.0026 16.7 3.7 3.5 2 2 1 3 3 3 3 MFS_1 like family OATP PF03137.20 ORX57641.1 - 3.6e-06 25.5 2.1 0.073 11.3 0.6 3.4 2 1 1 3 3 3 3 Organic Anion Transporter Polypeptide (OATP) family MFS_2 PF13347.6 ORX57641.1 - 1.5e-05 23.8 21.9 0.00013 20.6 6.6 2.9 2 1 1 3 3 3 2 MFS/sugar transport protein MFS_4 PF06779.14 ORX57641.1 - 0.00026 20.4 16.6 0.0015 17.9 2.4 3.3 2 1 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB Ldr_toxin PF13940.6 ORX57641.1 - 3.5 7.8 7.4 21 5.3 0.1 4.3 4 1 1 5 5 5 0 Toxin Ldr, type I toxin-antitoxin system DWNN PF08783.11 ORX57642.1 - 1.2e-25 89.6 0.6 1.8e-25 89.0 0.0 1.6 2 0 0 2 2 1 1 DWNN domain zf-CCHC_2 PF13696.6 ORX57642.1 - 8.6e-09 35.1 6.7 8.6e-09 35.1 6.7 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC PF00098.23 ORX57642.1 - 4.3e-06 26.6 2.1 1.2e-05 25.2 2.1 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-C3HC4_2 PF13923.6 ORX57642.1 - 1.5e-05 24.7 10.6 1.5e-05 24.7 10.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC_3 PF13917.6 ORX57642.1 - 0.0033 17.3 0.2 0.0033 17.3 0.2 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4 PF00097.25 ORX57642.1 - 0.0053 16.6 12.4 0.0053 16.6 12.4 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX57642.1 - 0.016 15.5 11.4 0.016 15.5 11.4 1.8 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 ORX57642.1 - 0.071 13.1 7.0 0.17 11.9 7.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX57642.1 - 0.21 11.5 17.0 0.034 14.0 10.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ORX57642.1 - 0.81 9.6 5.8 2 8.4 5.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ORX57642.1 - 1 9.5 16.8 0.065 13.4 11.4 1.9 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ORX57642.1 - 1.2 9.1 19.8 0.066 13.2 12.5 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_4 PF14570.6 ORX57642.1 - 1.9 8.3 11.1 4.1 7.3 11.1 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf_UBZ PF18439.1 ORX57642.1 - 9.5 5.9 8.5 7.5 6.2 0.1 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TFCD_C PF12612.8 ORX57643.1 - 1.1e-43 149.3 0.1 8.7e-43 146.4 0.0 2.5 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 ORX57643.1 - 1.4e-06 28.6 1.6 0.25 11.8 0.0 5.5 6 0 0 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 ORX57643.1 - 1.3e-05 25.6 0.6 0.11 13.0 0.0 5.9 6 2 0 6 6 6 1 HEAT-like repeat HEAT PF02985.22 ORX57643.1 - 0.00059 19.9 14.0 0.0082 16.3 0.0 7.6 9 0 0 9 9 9 1 HEAT repeat Cnd1 PF12717.7 ORX57643.1 - 0.013 15.5 0.0 7.8 6.5 0.0 3.6 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 NUC173 PF08161.12 ORX57643.1 - 0.079 12.6 0.1 0.96 9.1 0.0 2.6 2 0 0 2 2 2 0 NUC173 domain RTP1_C1 PF10363.9 ORX57643.1 - 0.14 12.4 0.1 0.83 9.9 0.0 2.4 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 B56 PF01603.20 ORX57643.1 - 0.14 11.1 1.0 0.57 9.1 0.1 2.5 3 0 0 3 3 3 0 Protein phosphatase 2A regulatory B subunit (B56 family) DUF2431 PF10354.9 ORX57644.1 - 4e-51 173.6 0.0 5.9e-51 173.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) DUF1385 PF07136.11 ORX57644.1 - 0.041 13.2 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) PHD PF00628.29 ORX57645.1 - 1.2e-05 25.1 10.1 3.9e-05 23.5 10.1 2.0 1 0 0 1 1 1 1 PHD-finger GATA PF00320.27 ORX57645.1 - 0.0003 20.3 5.6 0.0003 20.3 5.6 1.8 2 0 0 2 2 2 1 GATA zinc finger zf-PHD-like PF15446.6 ORX57645.1 - 0.0027 17.3 3.9 0.0057 16.3 3.9 1.6 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain PHD_2 PF13831.6 ORX57645.1 - 0.0048 16.4 1.6 0.012 15.1 1.6 1.7 1 0 0 1 1 1 1 PHD-finger DUF5030 PF16433.5 ORX57645.1 - 0.16 11.3 0.0 0.24 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5030) Zf_RING PF16744.5 ORX57645.1 - 0.21 11.8 2.4 0.5 10.5 2.4 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-HC5HC2H PF13771.6 ORX57645.1 - 0.32 11.3 10.0 0.081 13.2 4.3 2.6 1 1 1 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.22 ORX57645.1 - 0.65 9.9 9.3 0.052 13.4 2.4 2.5 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) BUD22 PF09073.10 ORX57645.1 - 1.1 8.5 9.8 1.5 8.1 9.8 1.1 1 0 0 1 1 1 0 BUD22 Nic96 PF04097.14 ORX57646.1 - 5e-82 276.3 6.1 6.8e-82 275.9 6.1 1.1 1 0 0 1 1 1 1 Nup93/Nic96 LIAS_N PF16881.5 ORX57647.1 - 2e-22 79.7 0.1 3.8e-22 78.8 0.1 1.4 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ORX57647.1 - 1.2e-13 51.8 0.1 1.8e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily adh_short_C2 PF13561.6 ORX57648.1 - 3.7e-49 167.4 5.6 6.7e-47 160.0 5.6 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX57648.1 - 6.3e-46 156.3 3.8 7.4e-46 156.1 3.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX57648.1 - 5.2e-13 49.3 1.0 8.2e-13 48.7 1.0 1.2 1 0 0 1 1 1 1 KR domain AdoHcyase_NAD PF00670.21 ORX57648.1 - 7.5e-05 22.8 0.9 0.00014 21.9 0.9 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 ORX57648.1 - 0.069 13.0 0.3 0.12 12.2 0.3 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lactamase_B PF00753.27 ORX57649.1 - 4.1e-17 62.9 3.4 9e-17 61.7 3.4 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ORX57649.1 - 7.3e-09 35.4 0.6 8.8e-09 35.2 0.6 1.0 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX57649.1 - 0.0024 17.8 0.3 0.0052 16.7 0.3 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain ADK PF00406.22 ORX57650.1 - 2.1e-47 161.0 0.1 2.7e-47 160.6 0.1 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ORX57650.1 - 2.9e-36 124.9 0.2 4.3e-36 124.3 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ORX57650.1 - 9.3e-11 42.4 0.0 1.4e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ORX57650.1 - 1.2e-07 31.6 1.2 2.4e-05 24.1 1.2 2.2 1 1 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.6 ORX57650.1 - 1.4e-06 28.5 0.0 3.2e-06 27.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ORX57650.1 - 0.0005 19.4 0.0 0.00074 18.8 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_28 PF13521.6 ORX57650.1 - 0.019 15.2 0.0 0.035 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Ribosomal_60s PF00428.19 ORX57651.1 - 2.9e-20 72.6 0.3 3.5e-20 72.4 0.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 ORX57651.1 - 0.055 13.9 0.5 0.055 13.9 0.5 1.7 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) tRNA-synt_1c PF00749.21 ORX57652.1 - 4.9e-111 370.6 0.1 1.1e-110 369.4 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ORX57652.1 - 1.2e-36 126.2 0.5 2.5e-36 125.2 0.5 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 ORX57652.1 - 0.0048 16.3 2.5 0.0091 15.4 2.5 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain GST_C_3 PF14497.6 ORX57652.1 - 0.0099 16.1 0.1 0.036 14.3 0.1 2.0 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX57652.1 - 0.016 15.4 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.27 ORX57653.1 - 1.6e-42 145.2 2.6 1.5e-22 80.6 0.0 3.8 3 1 0 3 3 3 2 ABC transporter AAA_21 PF13304.6 ORX57653.1 - 2.3e-17 63.8 11.1 4.4e-06 26.7 2.0 4.4 2 2 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX57653.1 - 1e-13 51.2 2.7 0.0028 17.1 0.0 4.4 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 ORX57653.1 - 4.6e-08 32.7 0.0 0.0003 20.5 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 ORX57653.1 - 2.4e-07 31.5 12.3 0.0013 19.3 0.1 4.1 3 1 1 4 4 4 2 AAA domain RsgA_GTPase PF03193.16 ORX57653.1 - 3e-06 27.3 1.9 0.039 13.9 0.0 3.1 4 0 0 4 4 2 2 RsgA GTPase ABC_tran_Xtn PF12848.7 ORX57653.1 - 4.1e-06 26.7 9.2 1.1e-05 25.4 9.2 1.6 1 0 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 ORX57653.1 - 7e-06 26.4 0.0 0.019 15.4 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_16 PF13191.6 ORX57653.1 - 1.1e-05 25.9 0.0 0.012 16.0 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 ORX57653.1 - 6.5e-05 22.8 2.7 0.14 11.8 0.0 3.5 3 0 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 ORX57653.1 - 8.3e-05 22.9 5.6 0.16 12.3 0.2 3.8 4 1 0 4 4 3 2 AAA domain AAA PF00004.29 ORX57653.1 - 0.00019 21.9 0.1 1.2 9.6 0.1 3.7 3 1 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX57653.1 - 0.00021 21.1 0.1 1.6 8.4 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 ORX57653.1 - 0.00039 20.5 0.4 1.1 9.3 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_27 PF13514.6 ORX57653.1 - 0.00054 19.6 0.0 0.26 10.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX57653.1 - 0.00077 19.2 1.2 0.79 9.4 0.0 3.3 3 1 0 3 3 3 2 AAA domain AAA_5 PF07728.14 ORX57653.1 - 0.00081 19.4 1.3 0.95 9.5 0.0 4.0 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ORX57653.1 - 0.0013 19.2 3.7 1.3 9.5 0.0 3.7 3 1 0 3 3 2 2 AAA domain Cytidylate_kin PF02224.18 ORX57653.1 - 0.0037 17.0 0.3 1.2 8.8 0.0 3.2 3 0 0 3 3 3 1 Cytidylate kinase AAA_7 PF12775.7 ORX57653.1 - 0.0038 16.8 0.1 1.3 8.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_33 PF13671.6 ORX57653.1 - 0.004 17.3 0.0 3.2 7.9 0.0 3.0 2 0 0 2 2 2 1 AAA domain Thymidylate_kin PF02223.17 ORX57653.1 - 0.012 15.4 3.5 2.3 7.9 0.9 3.5 4 0 0 4 4 3 0 Thymidylate kinase RseA_N PF03872.13 ORX57653.1 - 0.016 15.7 0.3 0.067 13.7 0.3 2.1 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain Ploopntkinase3 PF18751.1 ORX57653.1 - 0.018 15.0 0.0 6.7 6.6 0.0 2.4 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 IstB_IS21 PF01695.17 ORX57653.1 - 0.022 14.5 0.2 5.7 6.6 0.0 3.3 3 0 0 3 3 3 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 ORX57653.1 - 0.025 14.7 0.0 4.8 7.3 0.0 3.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase MeaB PF03308.16 ORX57653.1 - 0.047 12.7 0.1 0.99 8.3 0.0 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Rad17 PF03215.15 ORX57653.1 - 0.055 13.4 0.6 4.9 7.0 0.0 2.6 2 0 0 2 2 2 0 Rad17 P-loop domain NACHT PF05729.12 ORX57653.1 - 0.058 13.3 0.1 3.6 7.5 0.0 2.5 2 0 0 2 2 2 0 NACHT domain Mg_chelatase PF01078.21 ORX57653.1 - 0.12 11.8 3.3 16 4.8 0.1 3.7 4 1 0 4 4 4 0 Magnesium chelatase, subunit ChlI Remorin_C PF03763.13 ORX57653.1 - 0.15 11.9 4.0 0.34 10.8 4.0 1.5 1 0 0 1 1 1 0 Remorin, C-terminal region AAA_28 PF13521.6 ORX57653.1 - 0.15 12.3 0.3 4.5 7.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 ORX57653.1 - 0.46 10.4 3.4 2.5 8.0 0.0 3.8 5 0 0 5 5 4 0 NTPase DUF87 PF01935.17 ORX57653.1 - 2.2 8.3 6.6 4.2 7.4 0.0 3.5 3 1 0 3 3 3 0 Helicase HerA, central domain SWIRM PF04433.17 ORX57655.1 - 3.1e-11 43.4 0.7 7.5e-11 42.2 0.1 1.9 2 1 1 3 3 3 1 SWIRM domain MCD_N PF17408.2 ORX57655.1 - 0.0082 16.2 0.2 0.02 15.0 0.2 1.6 1 0 0 1 1 1 1 Malonyl-CoA decarboxylase N-terminal domain HAD_SAK_2 PF18143.1 ORX57655.1 - 0.028 14.7 2.9 0.74 10.1 2.2 2.1 1 1 1 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins LSM PF01423.22 ORX57656.1 - 1e-13 50.8 0.7 1.1e-12 47.4 0.7 2.0 1 1 0 1 1 1 1 LSM domain DUF3491 PF11996.8 ORX57656.1 - 0.18 9.6 0.0 0.2 9.4 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3491) HTH_17 PF12728.7 ORX57657.1 - 0.01 16.0 0.1 0.71 10.1 0.0 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_28 PF13518.6 ORX57657.1 - 0.02 15.0 0.3 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_32 PF13565.6 ORX57657.1 - 0.032 14.9 0.0 0.072 13.7 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain MepB PF08877.10 ORX57657.1 - 0.069 12.8 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 MepB protein ribosomal_L24 PF17136.4 ORX57658.1 - 8.9e-12 45.2 0.1 1.8e-11 44.3 0.1 1.6 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ORX57658.1 - 8.5e-06 25.5 2.4 2.3e-05 24.2 2.4 1.8 1 0 0 1 1 1 1 KOW motif HGTP_anticodon PF03129.20 ORX57659.1 - 1.6e-20 73.1 0.0 3.4e-20 72.0 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ORX57659.1 - 0.00055 20.0 0.0 0.0014 18.7 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_60s PF00428.19 ORX57660.1 - 1.4e-22 80.1 10.0 1.6e-22 79.9 10.0 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein FeS_assembly_P PF01883.19 ORX57661.1 - 5e-14 52.2 0.0 1.4e-13 50.8 0.0 1.8 2 1 0 2 2 2 1 Iron-sulfur cluster assembly protein HIT PF01230.23 ORX57662.1 - 1.4e-22 80.3 0.0 1.9e-22 79.8 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ORX57662.1 - 1.7e-05 25.3 0.0 2.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF4931 PF16285.5 ORX57662.1 - 0.035 13.4 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4931) GalP_UDP_tr_C PF02744.17 ORX57662.1 - 0.046 13.4 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain MAGE PF01454.19 ORX57663.1 - 5.8e-46 156.9 0.1 6.6e-46 156.7 0.1 1.0 1 0 0 1 1 1 1 MAGE family DUF5321 PF17254.2 ORX57663.1 - 0.045 13.2 0.0 0.063 12.7 0.0 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5321) EF-hand_8 PF13833.6 ORX57663.1 - 0.083 12.8 0.2 0.16 11.9 0.2 1.4 1 0 0 1 1 1 0 EF-hand domain pair SUB1_ProdP9 PF18213.1 ORX57663.1 - 0.12 12.3 0.1 0.22 11.4 0.1 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 His_biosynth PF00977.21 ORX57664.1 - 1.5e-35 122.7 0.0 1.8e-35 122.5 0.0 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Ribul_P_3_epim PF00834.19 ORX57664.1 - 0.19 11.1 0.0 0.28 10.5 0.0 1.2 1 0 0 1 1 1 0 Ribulose-phosphate 3 epimerase family STE PF02200.16 ORX57665.1 - 5.1e-54 181.4 0.0 8e-54 180.7 0.0 1.3 1 0 0 1 1 1 1 STE like transcription factor Phosphoesterase PF04185.14 ORX57666.1 - 1.2e-22 80.6 9.4 6.5e-22 78.2 6.0 2.7 1 1 1 2 2 2 1 Phosphoesterase family zf-RVT PF13966.6 ORX57667.1 - 4.4e-12 46.5 1.4 5.8e-12 46.2 1.4 1.2 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase Ribosomal_60s PF00428.19 ORX57668.1 - 4e-26 91.4 11.3 4.6e-26 91.2 11.3 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 ORX57668.1 - 0.52 11.0 4.4 0.7 10.5 4.4 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) zf-RVT PF13966.6 ORX57669.1 - 2.9e-10 40.7 0.3 4.9e-10 40.0 0.3 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-RVT PF13966.6 ORX57670.1 - 7.4e-11 42.6 1.2 8.9e-11 42.4 1.2 1.0 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase His_Me_b4a2 PF18275.1 ORX57670.1 - 0.1 12.7 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain Ribosomal_L38e PF01781.18 ORX57673.1 - 2.3e-33 114.1 3.0 2.5e-33 114.0 3.0 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family DAO PF01266.24 ORX57958.1 - 2.3e-32 113.0 0.1 3.5e-32 112.4 0.1 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX57958.1 - 0.0043 17.5 0.0 0.008 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Pyr_redox_2 PF07992.14 ORX57958.1 - 0.013 14.8 0.0 0.021 14.1 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX57958.1 - 0.017 14.2 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 ORX57958.1 - 0.026 14.7 0.0 0.064 13.5 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX57958.1 - 0.075 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain ApbA PF02558.16 ORX57958.1 - 0.15 11.7 0.1 0.29 10.8 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA VIT1 PF01988.19 ORX57959.1 - 9.7e-72 241.3 0.0 1.2e-71 241.0 0.0 1.1 1 0 0 1 1 1 1 VIT family DUF2070 PF09843.9 ORX57959.1 - 0.24 9.6 2.4 0.35 9.1 2.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Phosphoesterase PF04185.14 ORX57960.1 - 1.6e-83 280.9 1.1 2.2e-83 280.4 1.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family SIC PF03482.13 ORX57960.1 - 0.13 12.5 0.8 0.38 11.0 0.8 1.7 1 0 0 1 1 1 0 sic protein repeat Rogdi_lz PF10259.9 ORX57962.1 - 2.7e-29 102.5 0.4 7.8e-29 100.9 0.4 1.6 1 1 0 1 1 1 1 Rogdi leucine zipper containing protein bZIP_1 PF00170.21 ORX57963.1 - 5.3e-11 42.4 11.7 1.1e-10 41.5 11.7 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX57963.1 - 1.8e-06 28.0 12.0 3e-06 27.2 12.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX57963.1 - 0.0034 17.9 8.7 0.0067 16.9 8.7 1.5 1 0 0 1 1 1 1 bZIP Maf transcription factor CCDC-167 PF15188.6 ORX57963.1 - 4.6 7.6 6.7 14 6.1 6.7 1.8 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF5082 PF16888.5 ORX57964.1 - 0.056 13.7 1.1 0.077 13.3 1.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF4678 PF15727.5 ORX57964.1 - 0.26 10.5 2.9 0.31 10.3 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) GATA PF00320.27 ORX57965.1 - 7e-28 95.9 23.5 7.3e-15 54.3 7.3 2.7 2 0 0 2 2 2 2 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX57965.1 - 0.00017 21.1 10.9 0.011 15.2 1.8 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding eIF-5_eIF-2B PF01873.17 ORX57965.1 - 0.00072 19.4 6.1 0.032 14.1 0.6 2.3 2 0 0 2 2 2 2 Domain found in IF2B/IF5 TDP43_N PF18694.1 ORX57965.1 - 0.0014 18.4 0.1 0.59 10.0 0.0 2.4 2 0 0 2 2 2 2 Transactive response DNA-binding protein N-terminal domain Zn-ribbon_8 PF09723.10 ORX57965.1 - 0.013 15.6 6.6 0.47 10.6 0.4 2.8 2 1 0 2 2 2 0 Zinc ribbon domain Auto_anti-p27 PF06677.12 ORX57965.1 - 0.057 13.6 12.2 0.13 12.4 0.8 2.8 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) JAB PF01398.21 ORX57967.1 - 3.3e-34 117.4 2.3 3.8e-34 117.2 0.8 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 ORX57967.1 - 1.1e-17 64.7 1.3 2.5e-17 63.6 1.3 1.6 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 ORX57967.1 - 0.0028 17.4 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 ORX57967.1 - 0.04 14.0 0.2 0.14 12.2 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0172) GBP_repeat PF02526.14 ORX57967.1 - 0.065 13.0 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Glycophorin-binding protein DPBB_1 PF03330.18 ORX57968.1 - 0.00042 20.6 0.0 0.0011 19.2 0.0 1.7 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 ORX57968.1 - 0.011 15.6 0.0 0.021 14.7 0.0 1.4 1 0 0 1 1 1 0 Barwin family Mito_carr PF00153.27 ORX57970.1 - 1.3e-47 159.7 6.1 3.1e-18 65.5 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Yae1_N PF09811.9 ORX57971.1 - 5.1e-08 32.5 3.2 7.5e-08 31.9 3.2 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal RNA_pol_Rpb1_5 PF04998.17 ORX57972.1 - 8.9e-94 313.8 0.0 2.1e-93 312.6 0.0 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ORX57972.1 - 4.5e-67 225.4 0.1 8.4e-67 224.5 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ORX57972.1 - 2.4e-35 121.8 0.0 1.1e-34 119.7 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 ORX57972.1 - 2.9e-31 109.0 0.0 2e-30 106.2 0.0 2.4 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 ORX57972.1 - 1e-23 83.3 0.1 3.3e-23 81.7 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DUF4368 PF14287.6 ORX57972.1 - 0.042 14.1 0.1 0.18 12.1 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4368) Fer4_17 PF13534.6 ORX57972.1 - 0.56 10.8 2.9 4 8.0 0.0 3.3 3 0 0 3 3 3 0 4Fe-4S dicluster domain DUF1844 PF08899.11 ORX57975.1 - 0.069 13.5 2.4 3.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) DUF1963 PF09234.10 ORX57976.1 - 0.042 14.3 0.0 0.046 14.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) DUF2573 PF10835.8 ORX57976.1 - 0.15 12.4 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) DIOX_N PF14226.6 ORX57979.1 - 4.3e-30 104.9 0.2 1.4e-29 103.2 0.0 1.9 2 0 0 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ORX57979.1 - 2.3e-19 69.7 0.0 4.2e-19 68.9 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Peptidase_C14 PF00656.22 ORX57979.1 - 0.028 14.4 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Caspase domain DNA_binding_1 PF01035.20 ORX57980.1 - 9.3e-19 67.3 0.0 1.1e-18 67.1 0.0 1.1 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain V-SNARE_C PF12352.8 ORX57981.1 - 4.5e-10 39.7 4.3 5.1e-10 39.5 0.6 2.5 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ORX57981.1 - 2.9e-05 23.9 1.1 5e-05 23.1 0.1 1.9 2 1 0 2 2 2 1 Sec20 BAR_2 PF10455.9 ORX57981.1 - 0.0055 15.9 0.7 0.006 15.8 0.7 1.3 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking DUF4698 PF15769.5 ORX57981.1 - 0.062 12.3 4.8 0.048 12.7 2.8 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4698) DUF4404 PF14357.6 ORX57981.1 - 0.082 13.6 2.9 2.5 8.8 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) ArdA PF07275.11 ORX57981.1 - 0.11 13.0 0.6 0.37 11.4 0.6 1.7 1 1 0 1 1 1 0 Antirestriction protein (ArdA) SlyX PF04102.12 ORX57981.1 - 0.31 11.7 4.9 2.3 8.9 0.2 2.7 3 0 0 3 3 3 0 SlyX TPR_MLP1_2 PF07926.12 ORX57981.1 - 0.73 9.9 12.1 6.3 6.9 0.2 2.5 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein OmpH PF03938.14 ORX57981.1 - 0.86 9.9 7.7 1.3 9.3 5.1 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Noelin-1 PF12308.8 ORX57981.1 - 2.3 8.2 5.9 18 5.4 0.8 2.6 3 0 0 3 3 3 0 Neurogenesis glycoprotein Ribosomal_L19e PF01280.20 ORX57983.1 - 9.6e-63 210.5 10.0 9.6e-63 210.5 10.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e Lant_dehydr_C PF14028.6 ORX57983.1 - 0.0013 18.3 0.2 0.0022 17.6 0.2 1.3 1 0 0 1 1 1 1 Lantibiotic biosynthesis dehydratase C-term RabGAP-TBC PF00566.18 ORX57984.1 - 6.8e-49 166.4 0.5 1.4e-48 165.4 0.5 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain GRAM PF02893.20 ORX57984.1 - 8.3e-06 25.7 0.0 1.8e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 GRAM domain Sigma70_ner PF04546.13 ORX57984.1 - 0.0076 16.2 1.0 0.0076 16.2 1.0 1.9 2 0 0 2 2 2 1 Sigma-70, non-essential region EF-hand_6 PF13405.6 ORX57984.1 - 0.028 14.3 0.3 0.028 14.3 0.3 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 ORX57984.1 - 0.03 13.9 0.2 0.12 12.0 0.2 2.2 1 0 0 1 1 1 0 EF hand CNH PF00780.22 ORX57985.1 - 9.8e-40 136.9 0.1 1.5e-39 136.3 0.1 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX57985.1 - 1.9e-34 119.5 0.2 4.4e-34 118.3 0.2 1.7 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX57985.1 - 1.1e-20 74.2 0.0 2.1e-20 73.2 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ORX57985.1 - 1.5e-10 41.0 0.0 4.2e-10 39.6 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 ORX57985.1 - 0.057 13.9 0.0 0.58 10.7 0.0 2.8 3 0 0 3 3 3 0 PH domain E1_DerP2_DerF2 PF02221.15 ORX57986.1 - 1.6e-13 51.3 0.0 1.8e-13 51.0 0.0 1.0 1 0 0 1 1 1 1 ML domain ALO PF04030.14 ORX57987.1 - 4.3e-77 259.4 0.5 7.4e-77 258.7 0.5 1.4 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ORX57987.1 - 1e-29 103.1 0.1 1.4e-29 102.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain DUF1844 PF08899.11 ORX57988.1 - 0.2 11.9 3.0 4.9 7.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1844) CAP59_mtransfer PF11735.8 ORX57989.1 - 1.1e-67 228.2 0.0 1.3e-67 228.0 0.0 1.0 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 CsbD PF05532.12 ORX57990.1 - 5.4e-09 35.8 9.4 7.4e-08 32.2 7.6 2.3 2 0 0 2 2 2 1 CsbD-like Apolipoprotein PF01442.18 ORX57990.1 - 0.0013 18.6 0.7 0.0015 18.4 0.7 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Phasin PF05597.11 ORX57990.1 - 0.0019 18.2 1.3 0.0039 17.2 0.8 1.7 1 1 0 1 1 1 1 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF842 PF05811.13 ORX57990.1 - 0.003 17.2 3.6 0.025 14.3 3.8 2.2 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF842) DUF883 PF05957.13 ORX57990.1 - 0.018 15.7 5.1 0.26 11.9 2.0 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) Rh5 PF18515.1 ORX57990.1 - 0.096 12.0 6.5 0.13 11.5 6.5 1.2 1 0 0 1 1 1 0 Rh5 coiled-coil domain Prominin PF05478.11 ORX57990.1 - 0.1 10.6 4.3 0.1 10.5 4.3 1.2 1 0 0 1 1 1 0 Prominin Chlorosome_CsmC PF11098.8 ORX57990.1 - 0.18 11.8 12.6 2.8 7.9 3.8 2.3 1 1 1 2 2 2 0 Chlorosome envelope protein C HisKA_3 PF07730.13 ORX57990.1 - 0.18 12.4 2.8 10 6.7 2.8 2.9 1 1 0 1 1 1 0 Histidine kinase ATP-synt_B PF00430.18 ORX57990.1 - 0.19 11.8 12.6 3.3 7.8 0.2 2.7 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) Mitofilin PF09731.9 ORX57990.1 - 0.35 9.7 8.9 0.36 9.6 8.9 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Tyrosinase PF00264.20 ORX57990.1 - 0.88 9.8 9.7 1.1 9.5 9.7 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase DUF166 PF02593.14 ORX57990.1 - 0.98 8.9 5.7 7.8 6.0 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF4175 PF13779.6 ORX57990.1 - 1.1 7.1 13.4 1.1 7.1 13.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF359 PF04019.12 ORX57990.1 - 1.1 8.9 6.7 0.67 9.6 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF359) HrpE PF06188.12 ORX57990.1 - 1.2 9.0 7.7 1 9.2 4.1 1.9 1 1 1 2 2 2 0 HrpE/YscL/FliH and V-type ATPase subunit E YtxH PF12732.7 ORX57990.1 - 2 9.0 7.0 37 5.0 3.0 2.8 1 1 1 2 2 2 0 YtxH-like protein DivIVA PF05103.13 ORX57990.1 - 2.1 8.5 16.4 2 8.5 3.3 2.8 1 1 1 2 2 2 0 DivIVA protein FliE PF02049.18 ORX57990.1 - 8.5 6.6 22.5 5.7 7.1 12.7 2.7 1 1 2 3 3 3 0 Flagellar hook-basal body complex protein FliE ATP11 PF06644.11 ORX57991.1 - 1.9e-68 231.2 6.4 2.3e-68 231.0 6.4 1.0 1 0 0 1 1 1 1 ATP11 protein DUF2252 PF10009.9 ORX57991.1 - 0.45 9.5 4.5 0.7 8.9 4.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) RRM_1 PF00076.22 ORX57993.1 - 2.7e-18 65.5 0.1 4.8e-18 64.7 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HAND PF09110.11 ORX57993.1 - 0.00066 20.4 0.8 0.00066 20.4 0.8 2.5 2 1 0 2 2 2 1 HAND RRM_7 PF16367.5 ORX57993.1 - 0.0059 16.7 0.1 0.023 14.8 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif DDE_Tnp_1_6 PF13751.6 ORX57993.1 - 0.017 15.4 2.7 0.017 15.4 2.7 2.2 2 1 1 3 3 3 0 Transposase DDE domain RRM_Rrp7 PF17799.1 ORX57993.1 - 0.018 14.9 1.1 0.062 13.1 0.1 2.3 1 1 2 3 3 3 0 Rrp7 RRM-like N-terminal domain GxGYxYP_C PF14323.6 ORX57993.1 - 0.13 12.1 0.8 0.2 11.5 0.8 1.3 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain PHM7_cyt PF14703.6 ORX57993.1 - 0.15 12.3 0.2 0.15 12.3 0.2 4.1 2 2 2 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter SURF1 PF02104.15 ORX57994.1 - 7.5e-47 159.8 0.2 9.8e-47 159.5 0.2 1.1 1 0 0 1 1 1 1 SURF1 family bZIP_2 PF07716.15 ORX57995.1 - 4.3e-12 45.9 5.0 8.9e-12 44.9 5.0 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX57995.1 - 0.00057 19.9 4.8 0.0015 18.6 4.3 1.8 2 0 0 2 2 2 1 bZIP transcription factor GAGE PF05831.11 ORX57995.1 - 0.027 15.0 0.6 0.027 15.0 0.6 1.6 2 0 0 2 2 2 0 GAGE protein WD40_alt PF14077.6 ORX57995.1 - 0.076 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif Suf PF05843.14 ORX57995.1 - 0.11 12.5 0.9 0.13 12.2 0.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCDC106 PF15794.5 ORX57995.1 - 0.44 10.2 9.4 0.38 10.4 0.3 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 peroxidase PF00141.23 ORX57996.1 - 1.1e-36 126.7 0.0 1.7e-36 126.1 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Syntaxin PF00804.25 ORX57997.1 - 8.7e-26 90.8 5.7 8.7e-26 90.8 5.7 1.4 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 ORX57997.1 - 4.5e-12 45.8 1.6 8.8e-12 44.8 1.6 1.5 1 0 0 1 1 1 1 SNARE domain LMBR1 PF04791.16 ORX57997.1 - 0.00053 19.0 1.3 0.00057 18.9 1.3 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein SKA1 PF07160.12 ORX57997.1 - 0.00085 19.2 2.5 0.0013 18.7 2.5 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 1 MCU PF04678.13 ORX57997.1 - 0.011 15.8 0.7 0.015 15.4 0.7 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF4094 PF13334.6 ORX57997.1 - 0.012 16.0 1.3 0.023 15.1 0.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) V-SNARE PF05008.15 ORX57997.1 - 0.021 15.2 2.2 0.021 15.2 2.2 2.0 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus PDCD7 PF16021.5 ORX57997.1 - 0.046 12.8 2.9 0.06 12.5 2.9 1.3 1 0 0 1 1 1 0 Programmed cell death protein 7 DUF2207 PF09972.9 ORX57997.1 - 0.049 12.4 0.2 0.071 11.9 0.2 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MCPsignal PF00015.21 ORX57997.1 - 0.072 12.9 4.9 0.07 12.9 4.0 1.5 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Pox_EPC_I2-L1 PF12575.8 ORX57997.1 - 0.27 11.5 2.3 0.53 10.6 0.8 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DUF2368 PF10166.9 ORX57997.1 - 0.31 10.6 3.5 0.16 11.6 0.9 1.8 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) Synaptobrevin PF00957.21 ORX57997.1 - 0.49 10.2 6.4 0.093 12.5 2.9 1.7 2 0 0 2 2 2 0 Synaptobrevin DUF16 PF01519.16 ORX57997.1 - 2.1 8.9 9.0 0.3 11.6 4.2 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 A_deaminase PF00962.22 ORX57998.1 - 3.2e-124 414.5 0.0 5e-124 413.9 0.0 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase PRIMA1 PF16101.5 ORX57998.1 - 1.4 9.0 3.1 2.7 8.1 3.1 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 GST_N_3 PF13417.6 ORX57999.1 - 2.5e-10 40.6 0.0 5.8e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX57999.1 - 1.4e-09 38.1 0.0 2.5e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX57999.1 - 1.5e-08 34.9 0.1 4.9e-08 33.2 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX57999.1 - 6.2e-06 26.3 0.0 1.2e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX57999.1 - 2.4e-05 24.5 0.1 5.7e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX57999.1 - 0.0025 17.8 0.0 0.005 16.8 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain F-box-like PF12937.7 ORX58003.1 - 0.00013 21.8 0.0 0.00072 19.4 0.0 2.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX58003.1 - 0.0011 18.8 0.2 0.0043 16.9 0.2 2.0 1 0 0 1 1 1 1 F-box domain Tweety PF04906.13 ORX58005.1 - 0.0056 15.4 0.3 0.0064 15.2 0.3 1.1 1 0 0 1 1 1 1 Tweety GMC_oxred_N PF00732.19 ORX58006.1 - 1e-26 94.0 1.0 4.7e-26 91.8 1.0 2.0 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 ORX58006.1 - 8.6e-22 78.2 0.0 2.1e-21 76.9 0.0 1.7 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ORX58006.1 - 5.9e-06 25.6 6.0 0.014 14.5 3.4 2.4 3 0 0 3 3 3 2 FAD binding domain DAO PF01266.24 ORX58006.1 - 0.00031 20.4 0.0 0.34 10.4 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX58006.1 - 0.016 14.4 1.5 0.24 10.6 1.4 2.1 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX58006.1 - 0.035 14.3 1.3 0.067 13.4 0.4 2.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ORX58006.1 - 0.15 10.7 3.8 4.2 6.0 0.4 2.7 3 0 0 3 3 3 0 HI0933-like protein Pyr_redox_3 PF13738.6 ORX58006.1 - 0.49 9.6 2.5 16 4.7 1.3 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase EF-hand_4 PF12763.7 ORX58007.1 - 1.8e-26 92.1 0.0 9.4e-15 54.5 0.0 2.7 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SH3_9 PF14604.6 ORX58007.1 - 2.4e-17 62.5 3.9 4.6e-09 36.0 0.2 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX58007.1 - 6.6e-17 60.9 2.3 1.5e-08 34.1 0.3 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ORX58007.1 - 3.1e-12 46.0 0.0 3.3e-06 26.7 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain WH2 PF02205.20 ORX58007.1 - 4.1e-09 36.0 0.6 1.1e-08 34.6 0.6 1.8 1 0 0 1 1 1 1 WH2 motif EF-hand_1 PF00036.32 ORX58007.1 - 0.0018 17.7 0.3 0.015 14.8 0.1 2.7 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 ORX58007.1 - 0.005 17.3 0.1 0.23 12.0 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain pair SH3_3 PF08239.11 ORX58007.1 - 0.006 16.8 3.2 0.0074 16.5 0.2 2.5 3 0 0 3 3 2 1 Bacterial SH3 domain SH3_10 PF17902.1 ORX58007.1 - 0.035 14.2 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 SH3 domain EF-hand_6 PF13405.6 ORX58007.1 - 0.1 12.6 2.2 0.25 11.4 0.1 2.9 4 0 0 4 4 3 0 EF-hand domain SH3_4 PF06347.13 ORX58007.1 - 0.16 11.9 0.1 0.41 10.5 0.1 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain JmjC PF02373.22 ORX58008.1 - 3.6e-41 140.2 0.4 7.7e-41 139.1 0.4 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase ARID PF01388.21 ORX58008.1 - 2.9e-19 69.5 0.1 5.4e-19 68.7 0.1 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain JmjN PF02375.17 ORX58008.1 - 3.1e-16 59.0 2.8 7.3e-16 57.8 2.8 1.7 1 0 0 1 1 1 1 jmjN domain zf-C5HC2 PF02928.16 ORX58008.1 - 1.4e-13 51.0 13.2 1.4e-13 51.0 13.2 2.7 2 0 0 2 2 2 1 C5HC2 zinc finger PHD PF00628.29 ORX58008.1 - 5.3e-12 45.5 7.9 5.3e-12 45.5 7.9 2.6 2 0 0 2 2 2 1 PHD-finger SIR2 PF02146.17 ORX58009.1 - 1.6e-45 155.2 0.0 2.1e-45 154.8 0.0 1.1 1 0 0 1 1 1 1 Sir2 family Catalase_C PF18011.1 ORX58009.1 - 0.012 15.2 0.0 0.78 9.4 0.0 2.3 2 0 0 2 2 2 0 C-terminal domain found in long catalases cpYpsA PF12694.7 ORX58009.1 - 0.015 15.1 0.0 6.8 6.5 0.0 2.3 2 0 0 2 2 2 0 Circularly permutated YpsA SLOG family DUF364 PF04016.12 ORX58009.1 - 0.038 13.6 0.0 0.38 10.3 0.0 2.2 2 0 0 2 2 2 0 Putative heavy-metal chelation TPP_enzyme_M PF00205.22 ORX58009.1 - 0.039 13.7 0.0 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain DUF2529 PF10740.9 ORX58009.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) PS_pyruv_trans PF04230.13 ORX58009.1 - 0.09 12.7 0.0 0.26 11.2 0.0 1.8 1 1 0 2 2 2 0 Polysaccharide pyruvyl transferase PSP1 PF04468.12 ORX58010.1 - 4.7e-32 110.1 2.3 8.1e-32 109.4 2.3 1.4 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Ctf8 PF09696.10 ORX58011.1 - 3.4e-11 43.6 0.1 9.6e-11 42.2 0.1 1.7 1 1 0 1 1 1 1 Ctf8 DUF1958 PF09211.10 ORX58011.1 - 0.017 15.5 0.1 0.028 14.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1958) HARE-HTH PF05066.13 ORX58013.1 - 0.00065 20.0 0.0 0.0015 18.9 0.0 1.5 1 0 0 1 1 1 1 HB1, ASXL, restriction endonuclease HTH domain KilA-N PF04383.13 ORX58013.1 - 0.11 12.3 0.0 32 4.4 0.0 3.7 4 1 0 4 4 4 0 KilA-N domain IF-2B PF01008.17 ORX58014.1 - 1.5e-68 231.1 1.0 2.7e-68 230.2 1.0 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family DNA_RNApol_7kD PF03604.13 ORX58015.1 - 3.9e-18 64.8 5.1 3.9e-18 64.8 5.1 1.4 2 0 0 2 2 1 1 DNA directed RNA polymerase, 7 kDa subunit Zn_ribbon_recom PF13408.6 ORX58015.1 - 0.0023 18.4 1.9 0.1 13.1 0.3 2.1 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain DZR PF12773.7 ORX58015.1 - 0.0038 17.2 0.5 0.0049 16.9 0.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon NinF PF05810.12 ORX58015.1 - 0.0046 16.8 0.1 0.0053 16.6 0.1 1.2 1 0 0 1 1 1 1 NinF protein HypA PF01155.19 ORX58015.1 - 0.0052 16.8 0.2 0.0056 16.7 0.2 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA MCM_OB PF17207.3 ORX58015.1 - 0.0074 16.1 0.5 0.0079 16.0 0.5 1.1 1 0 0 1 1 1 1 MCM OB domain zinc_ribbon_10 PF10058.9 ORX58015.1 - 0.0078 15.9 1.0 0.39 10.5 0.1 2.1 1 1 1 2 2 2 2 Predicted integral membrane zinc-ribbon metal-binding protein zinc-ribbon_6 PF10005.9 ORX58015.1 - 0.012 16.3 0.2 0.015 16.0 0.2 1.2 1 0 0 1 1 1 0 zinc-ribbon domain TFIIS_C PF01096.18 ORX58015.1 - 0.017 15.0 0.6 2.9 7.8 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) TF_Zn_Ribbon PF08271.12 ORX58015.1 - 0.019 14.5 1.1 0.031 13.8 1.1 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding DUF35_N PF12172.8 ORX58015.1 - 0.02 14.7 0.5 3.1 7.7 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-NADH-PPase PF09297.11 ORX58015.1 - 0.021 14.5 3.1 0.064 12.9 3.1 1.8 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain PhnA_Zn_Ribbon PF08274.12 ORX58015.1 - 0.033 14.2 1.4 0.11 12.5 1.6 1.7 1 1 1 2 2 2 0 PhnA Zinc-Ribbon OrfB_Zn_ribbon PF07282.11 ORX58015.1 - 0.035 14.0 0.9 0.044 13.7 0.9 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain A2L_zn_ribbon PF08792.10 ORX58015.1 - 0.04 13.6 1.4 1.4 8.7 0.2 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain Zn-ribbon_8 PF09723.10 ORX58015.1 - 0.058 13.5 4.0 0.31 11.2 3.8 2.1 1 1 1 2 2 2 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 ORX58015.1 - 0.062 13.0 4.2 3.2 7.5 0.2 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf_UBZ PF18439.1 ORX58015.1 - 0.067 12.8 2.4 4.1 7.1 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF951 PF06107.11 ORX58015.1 - 0.083 12.8 0.7 0.083 12.8 0.7 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF951) DUF1451 PF07295.11 ORX58015.1 - 0.097 12.7 0.5 0.12 12.4 0.5 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain zinc_ribbon_2 PF13240.6 ORX58015.1 - 0.11 12.2 2.9 1.3 8.8 3.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain zf-dskA_traR PF01258.17 ORX58015.1 - 0.11 12.4 4.1 0.76 9.8 0.3 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-trcl PF13451.6 ORX58015.1 - 0.12 12.3 4.6 3.9 7.5 0.5 2.2 1 1 1 2 2 2 0 Probable zinc-ribbon domain zinc_ribbon_13 PF09855.9 ORX58015.1 - 0.21 11.8 1.4 0.37 11.0 0.1 1.8 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zinc_ribbon_6 PF14599.6 ORX58015.1 - 0.22 11.6 3.1 3.8 7.6 0.2 2.2 1 1 1 2 2 2 0 Zinc-ribbon F-box-like PF12937.7 ORX58016.1 - 1e-06 28.5 1.4 2.1e-06 27.5 0.6 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX58016.1 - 3.4e-06 26.8 0.2 7.9e-06 25.6 0.2 1.6 1 0 0 1 1 1 1 F-box domain WD40 PF00400.32 ORX58016.1 - 0.0001 23.0 5.4 0.073 14.0 0.1 5.3 5 0 0 5 5 5 2 WD domain, G-beta repeat DUF262 PF03235.14 ORX58017.1 - 1.2e-08 35.5 0.0 2.5e-08 34.4 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function DUF262 VF530 PF09905.9 ORX58017.1 - 0.18 12.0 0.0 0.57 10.4 0.0 1.8 2 0 0 2 2 2 0 DNA-binding protein VF530 SET PF00856.28 ORX58018.1 - 2.2e-09 37.9 0.2 7.3e-09 36.2 0.2 1.9 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ORX58018.1 - 1.2e-06 28.4 7.2 1.2e-06 28.4 7.2 3.8 2 1 0 2 2 2 1 MYND finger zf-Mss51 PF13824.6 ORX58018.1 - 0.0019 18.3 4.2 0.0019 18.3 4.2 2.5 2 1 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 MMU163 PF17119.5 ORX58019.1 - 0.00074 18.8 0.0 0.00099 18.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial protein up-regulated during meiosis DUF2358 PF10184.9 ORX58019.1 - 0.09 13.1 0.0 0.84 9.9 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) FA_hydroxylase PF04116.13 ORX58020.1 - 1.8e-20 73.7 23.7 1.8e-20 73.7 23.7 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily MRP-S26 PF14943.6 ORX58021.1 - 0.0013 18.7 13.0 0.0039 17.1 13.0 1.7 1 1 0 1 1 1 1 Mitochondrial ribosome subunit S26 MADF_DNA_bdg PF10545.9 ORX58021.1 - 1.7 9.0 7.1 0.6 10.5 0.8 2.8 1 1 2 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Exonuc_VII_L PF02601.15 ORX58021.1 - 3.2 7.3 12.2 4 6.9 12.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HlyIII PF03006.20 ORX58022.1 - 4.8e-60 203.1 27.4 5.7e-60 202.8 27.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related Myco_arth_vir_N PF09610.10 ORX58022.1 - 0.15 12.1 0.1 0.15 12.1 0.1 2.4 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Homeobox_KN PF05920.11 ORX58023.1 - 4.2e-19 68.2 3.5 1.2e-18 66.7 3.5 1.8 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX58023.1 - 1e-07 31.7 1.2 2.5e-07 30.4 1.2 1.7 1 0 0 1 1 1 1 Homeodomain ABC2_membrane PF01061.24 ORX58024.1 - 1.5e-40 138.9 17.4 2.9e-40 137.9 17.4 1.5 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 ORX58024.1 - 1.3e-29 103.5 0.0 2.8e-29 102.4 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX58024.1 - 1.7e-07 31.4 0.0 0.0071 16.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX58024.1 - 9.4e-06 25.2 0.0 9.7e-05 21.9 0.0 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ORX58024.1 - 0.00013 21.9 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 ORX58024.1 - 0.00014 21.1 15.3 0.00014 21.1 15.3 2.0 2 1 1 3 3 3 1 ABC-2 family transporter protein AAA_29 PF13555.6 ORX58024.1 - 0.00061 19.5 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 ORX58024.1 - 0.0034 17.0 0.0 0.019 14.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX58024.1 - 0.0036 17.9 0.0 0.013 16.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain ABC2_membrane_2 PF12679.7 ORX58024.1 - 0.0079 15.5 9.2 0.017 14.4 9.2 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein AAA_22 PF13401.6 ORX58024.1 - 0.0085 16.4 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX58024.1 - 0.01 16.3 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 ORX58024.1 - 0.011 15.6 0.0 0.18 11.7 0.0 2.7 3 0 0 3 3 3 0 Rad17 P-loop domain AAA_33 PF13671.6 ORX58024.1 - 0.041 14.0 0.0 0.081 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX58024.1 - 0.05 14.1 0.0 0.09 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain RexB PF15968.5 ORX58024.1 - 0.062 13.8 5.0 1.2 9.6 0.1 2.9 2 1 1 3 3 3 0 Membrane-anchored ion channel, Abi component AAA_30 PF13604.6 ORX58024.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain NUDIX PF00293.28 ORX58025.1 - 1.9e-12 47.3 0.3 3e-12 46.7 0.3 1.3 1 0 0 1 1 1 1 NUDIX domain GlgX_C PF18390.1 ORX58025.1 - 0.038 13.8 0.0 0.094 12.5 0.0 1.7 1 0 0 1 1 1 0 Glycogen debranching enzyme C-terminal domain NTR PF01759.21 ORX58025.1 - 0.05 13.4 0.1 5.3 6.9 0.1 2.3 2 0 0 2 2 2 0 UNC-6/NTR/C345C module Mem_trans PF03547.18 ORX58026.1 - 2.1e-38 131.7 9.1 7.1e-38 130.0 9.1 1.8 1 1 0 1 1 1 1 Membrane transport protein EAP30 PF04157.16 ORX58027.1 - 7.5e-69 231.6 0.1 8.5e-69 231.4 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family Phage_Mu_Gam PF07352.12 ORX58027.1 - 0.06 13.2 0.3 0.06 13.2 0.3 1.8 3 0 0 3 3 3 0 Bacteriophage Mu Gam like protein DUF3850 PF12961.7 ORX58027.1 - 0.25 11.4 1.8 22 5.2 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3850) APG6 PF04111.12 ORX58028.1 - 3.1e-74 248.8 0.0 5.8e-74 247.9 0.0 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 ORX58028.1 - 1.3e-32 113.2 7.0 2.4e-32 112.3 7.0 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region BH3 PF15285.6 ORX58028.1 - 9.6e-06 25.2 0.2 2.5e-05 23.9 0.2 1.7 1 0 0 1 1 1 1 Beclin-1 BH3 domain, Bcl-2-interacting Seryl_tRNA_N PF02403.22 ORX58028.1 - 0.0075 16.5 2.0 0.016 15.4 2.0 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ADIP PF11559.8 ORX58028.1 - 0.023 14.8 6.2 0.061 13.4 6.2 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Lipoprotein_7 PF01540.16 ORX58028.1 - 0.037 13.3 0.1 0.057 12.7 0.1 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein Mononeg_mRNAcap PF14318.6 ORX58028.1 - 0.13 11.5 1.0 3.4 6.8 0.2 2.3 2 0 0 2 2 2 0 Mononegavirales mRNA-capping region V Rib_hydrolayse PF02267.17 ORX58028.1 - 0.34 10.3 3.6 1.7 8.0 0.6 2.2 2 0 0 2 2 2 0 ADP-ribosyl cyclase DUF3450 PF11932.8 ORX58028.1 - 7.2 5.8 14.2 21 4.3 14.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 ORX58028.1 - 8.2 6.5 12.3 1.8 8.7 8.7 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus NAD_Gly3P_dh_N PF01210.23 ORX58029.1 - 5.3e-50 169.5 0.0 6.5e-49 165.9 0.0 2.0 2 0 0 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ORX58029.1 - 1.7e-46 158.0 0.0 3.3e-46 157.1 0.0 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 ORX58029.1 - 0.0031 18.1 0.2 0.1 13.2 0.2 2.4 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Semialdhyde_dh PF01118.24 ORX58029.1 - 0.14 12.6 0.0 0.41 11.1 0.0 1.7 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Mito_carr PF00153.27 ORX58030.1 - 1.8e-48 162.4 5.5 1.3e-19 69.9 0.0 4.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Snf7 PF03357.21 ORX58031.1 - 1.6e-41 141.8 10.2 1.8e-41 141.6 10.2 1.0 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 ORX58031.1 - 0.00038 20.9 7.7 0.0058 17.1 2.3 2.5 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Prefoldin_2 PF01920.20 ORX58031.1 - 0.0013 18.7 11.9 0.029 14.3 0.0 3.3 2 1 0 2 2 2 1 Prefoldin subunit Wtap PF17098.5 ORX58031.1 - 0.0027 17.7 8.0 0.017 15.1 8.0 1.9 1 1 0 1 1 1 1 WTAP/Mum2p family Peptidase_M3_N PF08439.10 ORX58031.1 - 0.0067 16.7 0.2 0.018 15.3 0.0 1.8 2 0 0 2 2 2 1 Oligopeptidase F FlaC_arch PF05377.11 ORX58031.1 - 0.0072 16.7 4.6 0.68 10.4 0.0 3.2 2 1 1 3 3 3 1 Flagella accessory protein C (FlaC) Sec34 PF04136.15 ORX58031.1 - 0.087 12.7 4.9 0.064 13.1 2.0 1.9 2 0 0 2 2 2 0 Sec34-like family WDCP PF15390.6 ORX58031.1 - 0.14 10.5 1.7 0.14 10.5 1.7 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Uso1_p115_C PF04871.13 ORX58031.1 - 0.15 12.4 13.9 0.4 11.1 11.7 2.2 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Prefoldin PF02996.17 ORX58031.1 - 0.19 11.7 11.1 2.4 8.1 2.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit APG6_N PF17675.1 ORX58031.1 - 0.2 12.2 10.7 1.4 9.5 3.3 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region zf-C4H2 PF10146.9 ORX58031.1 - 0.26 11.6 6.8 0.34 11.2 5.8 1.6 1 1 0 1 1 1 0 Zinc finger-containing protein Mito_fiss_reg PF05308.11 ORX58031.1 - 0.31 11.1 6.5 0.94 9.5 2.9 2.0 1 1 1 2 2 2 0 Mitochondrial fission regulator DUF948 PF06103.11 ORX58031.1 - 0.68 10.2 6.0 2.2 8.6 3.9 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) XhlA PF10779.9 ORX58031.1 - 1 9.6 5.0 9.9 6.5 1.2 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Ribosomal_L27A PF00828.19 ORX58031.1 - 1.1 9.9 4.2 2.4 8.9 1.7 2.3 1 1 1 2 2 2 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DUF4140 PF13600.6 ORX58031.1 - 2.6 8.6 11.9 6.4 7.3 0.2 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3007 PF11460.8 ORX58031.1 - 6.5 7.1 5.9 2.1 8.7 1.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3007) Tho2 PF11262.8 ORX58031.1 - 7.3 5.7 7.8 42 3.2 7.8 1.9 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 CorA PF01544.18 ORX58031.1 - 8.3 5.6 9.3 15 4.8 8.7 1.8 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein STE PF02200.16 ORX58033.1 - 0.069 13.6 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 STE like transcription factor Ras PF00071.22 ORX58034.1 - 5.2e-49 166.0 0.2 5.9e-49 165.8 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX58034.1 - 1.2e-16 61.0 0.0 1.8e-16 60.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX58034.1 - 6.5e-10 38.7 0.0 7.1e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX58034.1 - 4.9e-08 33.1 0.3 5.5e-05 23.1 0.0 2.1 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX58034.1 - 7.3e-08 32.2 0.3 9.6e-07 28.5 0.3 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX58034.1 - 5.4e-07 29.3 0.1 2.1e-06 27.3 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B MMR_HSR1 PF01926.23 ORX58034.1 - 1.6e-05 25.0 0.0 2.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX58034.1 - 0.00043 19.8 0.1 0.00051 19.5 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 ORX58034.1 - 0.014 15.4 0.1 0.042 13.9 0.0 1.7 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain MeaB PF03308.16 ORX58034.1 - 0.015 14.3 0.0 0.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TniB PF05621.11 ORX58034.1 - 0.034 13.6 0.0 0.16 11.4 0.0 2.1 2 2 0 2 2 2 0 Bacterial TniB protein OrfB_Zn_ribbon PF07282.11 ORX58035.1 - 0.037 13.9 0.8 0.34 10.9 0.0 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain HSP70 PF00012.20 ORX58036.1 - 9.6e-08 30.7 0.0 1.3e-06 27.0 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ORX58036.1 - 0.075 11.8 0.0 0.7 8.6 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein CPSF73-100_C PF11718.8 ORX58037.1 - 1.7e-51 174.8 2.9 1.9e-51 174.7 1.8 1.6 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 ORX58037.1 - 4e-31 107.6 0.0 1.1e-30 106.2 0.0 1.7 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ORX58037.1 - 2.8e-22 79.1 1.1 1.9e-21 76.4 0.2 2.6 3 0 0 3 3 3 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX58037.1 - 8.8e-21 74.8 0.8 1.5e-20 74.0 0.8 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ORX58037.1 - 8e-17 60.9 0.1 1.7e-16 59.9 0.1 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ORX58037.1 - 4.8e-09 36.0 1.9 7.7e-09 35.4 0.3 2.1 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX58037.1 - 2.5e-07 30.7 1.9 8.3e-07 29.0 0.4 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 ORX58037.1 - 5.5e-05 22.5 0.1 0.00031 20.1 0.0 2.2 2 0 0 2 2 2 1 Putative beta-lactamase-like family TSNAXIP1_N PF15739.5 ORX58037.1 - 0.035 14.5 0.2 0.1 13.0 0.2 1.7 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus baeRF_family2 PF18844.1 ORX58037.1 - 0.058 13.4 0.3 2.4 8.2 0.0 2.7 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 2 DUF4083 PF13314.6 ORX58038.1 - 0.013 15.5 0.0 0.033 14.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Peptidase_M3 PF01432.20 ORX58039.1 - 1.3e-140 469.7 1.5 1.8e-140 469.2 1.5 1.2 1 0 0 1 1 1 1 Peptidase family M3 Chromo_shadow PF01393.19 ORX58040.1 - 0.029 14.5 0.0 0.048 13.8 0.0 1.4 1 0 0 1 1 1 0 Chromo shadow domain Nop53 PF07767.11 ORX58041.1 - 1.6e-83 281.4 29.5 1.6e-83 281.4 29.5 1.3 2 0 0 2 2 2 1 Nop53 (60S ribosomal biogenesis) Ribosomal_S25 PF03297.15 ORX58041.1 - 0.018 15.2 3.2 0.018 15.2 3.2 3.7 4 0 0 4 4 4 0 S25 ribosomal protein RecC_C PF17946.1 ORX58041.1 - 0.072 12.9 2.7 0.88 9.3 0.1 2.3 2 0 0 2 2 2 0 RecC C-terminal domain ENTH PF01417.20 ORX58042.1 - 9.1e-31 106.5 0.1 5.1e-23 81.5 0.0 2.4 1 1 1 2 2 2 2 ENTH domain UIM PF02809.20 ORX58042.1 - 9.9e-05 22.0 10.1 0.0041 16.9 3.7 2.6 2 0 0 2 2 2 2 Ubiquitin interaction motif ANTH PF07651.16 ORX58042.1 - 0.0051 15.8 0.2 0.008 15.2 0.2 1.4 1 1 0 1 1 1 1 ANTH domain Hexokinase_1 PF00349.21 ORX58042.1 - 0.14 12.1 3.0 0.1 12.5 0.6 1.9 2 0 0 2 2 2 0 Hexokinase RAP80_UIM PF18282.1 ORX58042.1 - 0.27 11.1 10.2 0.36 10.6 5.8 2.5 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif Kelch_1 PF01344.25 ORX58043.1 - 1.3e-44 149.6 3.0 1e-07 31.4 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ORX58043.1 - 1e-41 140.7 14.9 2.3e-08 33.9 0.1 6.2 4 2 2 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX58043.1 - 9.2e-39 131.0 12.1 2.1e-07 31.0 0.1 6.4 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX58043.1 - 1.4e-36 123.6 11.8 9.6e-07 28.9 0.1 6.3 2 2 4 6 6 6 6 Kelch motif Kelch_5 PF13854.6 ORX58043.1 - 2.2e-36 123.3 7.6 2e-06 27.6 0.1 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_2 PF07646.15 ORX58043.1 - 3.3e-28 96.6 3.5 1.3e-05 25.0 0.0 6.6 6 0 0 6 6 6 6 Kelch motif Iwr1 PF08574.10 ORX58044.1 - 6.7e-12 46.2 14.8 6.7e-12 46.2 14.8 2.8 3 0 0 3 3 3 1 Transcription factor Iwr1 Asp PF00026.23 ORX58047.1 - 2.4e-07 30.5 0.0 2.4e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease LSM PF01423.22 ORX58047.1 - 0.0056 16.3 0.0 0.0074 16.0 0.0 1.2 1 0 0 1 1 1 1 LSM domain DUF4690 PF15756.5 ORX58048.1 - 0.062 13.9 0.1 0.15 12.7 0.0 1.6 2 0 0 2 2 2 0 Small Novel Rich in Cartilage Mem_trans PF03547.18 ORX58048.1 - 0.13 10.6 2.4 0.38 9.1 2.2 1.9 1 1 1 2 2 2 0 Membrane transport protein PMP22_Claudin PF00822.20 ORX58048.1 - 0.21 11.5 9.3 0.32 10.9 9.3 1.5 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Amastin PF07344.11 ORX58048.1 - 0.4 10.5 16.3 1.2 9.0 15.7 1.9 1 1 1 2 2 2 0 Amastin surface glycoprotein RCR PF12273.8 ORX58048.1 - 0.52 11.0 2.5 2.3 8.9 1.0 2.4 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red FAM176 PF14851.6 ORX58048.1 - 2.2 7.9 3.3 4.1 7.1 0.1 2.1 2 0 0 2 2 2 0 FAM176 family DEAD PF00270.29 ORX58049.1 - 1.1e-48 165.4 0.0 1.7e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX58049.1 - 9e-30 103.3 0.0 3.7e-29 101.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX58049.1 - 4.4e-05 23.5 0.0 8.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4611 PF15387.6 ORX58049.1 - 0.049 13.9 3.2 0.092 13.0 3.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CwfJ_C_2 PF04676.14 ORX58050.1 - 7.1e-34 116.7 0.8 7.1e-34 116.7 0.8 2.7 4 0 0 4 4 4 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 ORX58050.1 - 8.6e-30 103.1 0.4 2.2e-29 101.8 0.4 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 zf-NOSIP PF15906.5 ORX58051.1 - 8.9e-14 51.4 0.5 1.7e-13 50.5 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_3 PF13920.6 ORX58051.1 - 4.7e-10 39.2 19.7 3.2e-07 30.1 9.7 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX58051.1 - 1.1e-07 32.1 19.9 1.2e-06 28.7 10.0 2.5 2 0 0 2 2 2 2 Ring finger domain Prok-RING_4 PF14447.6 ORX58051.1 - 1.1e-07 31.6 20.6 0.00024 20.9 10.8 3.3 2 1 1 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ORX58051.1 - 3.1e-07 30.2 20.5 7.3e-06 25.8 10.5 2.4 2 0 0 2 2 2 2 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX58051.1 - 4.6e-07 29.8 19.4 0.0013 18.7 10.6 2.4 2 0 0 2 2 2 2 RING-type zinc-finger Rtf2 PF04641.12 ORX58051.1 - 7.2e-06 25.6 8.3 7.2e-06 25.6 8.3 2.4 1 1 1 2 2 1 1 Rtf2 RING-finger zf-C3HC4 PF00097.25 ORX58051.1 - 0.00018 21.3 20.7 0.0046 16.8 10.1 2.5 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX58051.1 - 0.00075 19.3 20.9 0.014 15.3 10.4 2.6 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ORX58051.1 - 0.0026 17.9 19.6 0.32 11.2 1.9 3.1 2 1 1 3 3 3 2 zinc finger of C3HC4-type, RING zf-P11 PF03854.14 ORX58051.1 - 1.1 9.0 18.3 0.97 9.1 7.9 2.7 2 1 0 2 2 2 0 P-11 zinc finger zf-RanBP PF00641.18 ORX58051.1 - 5.4 6.4 7.9 12 5.3 0.5 3.5 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others FYVE PF01363.21 ORX58051.1 - 7 6.9 19.2 0.077 13.1 7.4 2.9 3 1 0 3 3 2 0 FYVE zinc finger Vps39_2 PF10367.9 ORX58051.1 - 7.3 7.1 16.9 2.3 8.7 3.7 3.3 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 2 HSF_DNA-bind PF00447.17 ORX58052.1 - 6.4e-28 97.2 2.5 6.4e-28 97.2 2.5 2.1 2 1 0 2 2 2 1 HSF-type DNA-binding DUF4763 PF15960.5 ORX58052.1 - 0.0012 18.3 2.7 0.0012 18.3 2.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4763) BAR_3 PF16746.5 ORX58052.1 - 0.0046 16.7 1.1 0.0046 16.7 1.1 1.6 2 0 0 2 2 2 1 BAR domain of APPL family APG6_N PF17675.1 ORX58052.1 - 0.018 15.6 1.0 0.037 14.6 1.0 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Snapin_Pallidin PF14712.6 ORX58052.1 - 0.038 14.4 1.4 0.038 14.4 1.4 2.1 3 0 0 3 3 2 0 Snapin/Pallidin Leu_zip PF15294.6 ORX58052.1 - 0.056 13.0 2.6 0.078 12.5 2.6 1.1 1 0 0 1 1 1 0 Leucine zipper Nsp1_C PF05064.13 ORX58052.1 - 0.074 12.9 2.0 0.16 11.7 2.0 1.5 1 0 0 1 1 1 0 Nsp1-like C-terminal region Adeno_E3 PF06040.11 ORX58052.1 - 0.089 13.0 0.8 0.29 11.3 0.6 1.9 1 1 0 1 1 1 0 Adenovirus E3 protein DUF1572 PF07609.11 ORX58052.1 - 0.12 12.1 2.3 2.5 7.9 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1572) DUF16 PF01519.16 ORX58052.1 - 0.14 12.6 6.9 0.17 12.4 3.8 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 Baculo_PEP_C PF04513.12 ORX58052.1 - 0.23 11.5 2.1 0.35 10.9 0.5 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RasGAP_C PF03836.15 ORX58052.1 - 0.27 11.4 5.2 0.58 10.3 5.2 1.5 1 0 0 1 1 1 0 RasGAP C-terminus CENP-F_leu_zip PF10473.9 ORX58052.1 - 0.42 10.6 4.3 0.27 11.2 2.1 1.8 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMPIT PF07851.13 ORX58052.1 - 0.53 9.5 7.1 0.75 9.0 7.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein Prefoldin PF02996.17 ORX58052.1 - 2.4 8.1 4.7 1.1 9.2 0.8 2.1 2 0 0 2 2 2 0 Prefoldin subunit TolA_bind_tri PF16331.5 ORX58052.1 - 6.2 7.0 7.3 0.85 9.7 1.1 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation PRKG1_interact PF15898.5 ORX58052.1 - 7.3 7.6 6.6 4.4 8.3 2.4 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4420 PF14390.6 ORX58053.1 - 0.076 12.2 0.7 0.13 11.5 0.1 1.5 1 1 1 2 2 2 0 Putative PD-(D/E)XK family member, (DUF4420) TruD PF01142.18 ORX58056.1 - 6.6e-68 229.4 0.0 8e-65 219.3 0.0 2.9 2 1 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) FmiP_Thoc5 PF09766.9 ORX58056.1 - 0.074 12.3 0.5 0.29 10.4 0.0 1.9 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 Uricase PF01014.18 ORX58057.1 - 3.2e-60 202.1 8.6 2.2e-30 105.6 0.1 3.3 2 2 0 2 2 2 2 Uricase FolB PF02152.18 ORX58057.1 - 0.0022 18.5 0.6 0.013 16.0 0.2 2.0 2 0 0 2 2 2 1 Dihydroneopterin aldolase Allantoicase PF03561.15 ORX58058.1 - 3.6e-81 270.2 0.0 2.7e-42 144.2 0.0 2.2 2 0 0 2 2 2 2 Allantoicase repeat Ureidogly_lyase PF04115.12 ORX58058.1 - 1.5e-50 171.5 0.1 2.4e-50 170.9 0.1 1.2 1 0 0 1 1 1 1 Ureidoglycolate lyase DUF4508 PF14969.6 ORX58059.1 - 0.013 15.8 0.2 0.017 15.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) SAM_1 PF00536.30 ORX58060.1 - 6.4e-07 29.7 0.1 7.4e-07 29.5 0.1 1.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ORX58060.1 - 1.4e-06 28.3 0.1 1.9e-06 27.9 0.1 1.3 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) IGR PF09597.10 ORX58060.1 - 0.0036 17.4 0.1 0.0042 17.2 0.1 1.1 1 0 0 1 1 1 1 IGR protein motif Ribosomal_L30 PF00327.20 ORX58060.1 - 0.024 14.5 0.0 0.042 13.7 0.0 1.5 2 0 0 2 2 2 0 Ribosomal protein L30p/L7e Ribosomal_L29e PF01779.17 ORX58061.1 - 4.3e-23 81.3 9.6 5.7e-23 80.9 9.6 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family RraA-like PF03737.15 ORX58063.1 - 5.1e-35 120.9 0.0 6.4e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA Med20 PF08612.11 ORX58064.1 - 2.4e-28 99.0 0.0 2.9e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex TPR_2 PF07719.17 ORX58068.1 - 4.9e-11 41.9 18.8 0.00034 20.5 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX58068.1 - 3.2e-10 40.4 9.6 0.0071 16.8 1.7 3.9 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX58068.1 - 8.7e-10 38.3 0.5 0.082 13.3 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ORX58068.1 - 1.3e-06 28.1 13.5 2.5e-06 27.1 12.5 1.8 1 1 1 2 2 2 2 MalT-like TPR region TPR_8 PF13181.6 ORX58068.1 - 1.9e-06 27.6 13.3 0.18 12.1 0.0 6.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX58068.1 - 3.5e-06 27.6 9.8 0.12 13.0 0.4 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX58068.1 - 4.9e-06 26.7 6.8 0.84 9.9 0.1 3.6 3 1 0 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ORX58068.1 - 7e-06 26.4 16.7 1.3 10.0 0.0 6.2 4 3 3 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX58068.1 - 0.00014 21.5 13.9 0.28 11.1 0.4 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX58068.1 - 0.0011 19.2 16.0 0.017 15.4 0.7 4.8 5 1 1 6 6 5 3 Tetratricopeptide repeat PknG_TPR PF16918.5 ORX58068.1 - 0.0014 17.4 0.3 0.0036 16.1 0.1 1.7 2 0 0 2 2 2 1 Protein kinase G tetratricopeptide repeat TPR_11 PF13414.6 ORX58068.1 - 0.0022 17.7 3.5 1.1 9.0 0.0 5.0 3 2 2 5 5 5 1 TPR repeat TPR_9 PF13371.6 ORX58068.1 - 0.0048 17.0 9.8 0.11 12.7 0.1 4.1 3 1 2 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 ORX58068.1 - 0.084 13.0 2.6 3.7 7.7 0.0 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 ORX58068.1 - 0.1 12.7 4.9 2.1 8.6 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_21 PF09976.9 ORX58068.1 - 2.7 7.7 9.2 3.3 7.4 3.1 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain Myb_DNA-binding PF00249.31 ORX58069.1 - 0.0059 16.8 0.0 0.0093 16.1 0.0 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX58069.1 - 0.021 15.1 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain MAPEG PF01124.18 ORX58070.1 - 8.8e-05 22.4 10.0 0.00011 22.1 10.0 1.1 1 0 0 1 1 1 1 MAPEG family EB1 PF03271.17 ORX58071.1 - 5e-17 61.9 1.3 9.3e-17 61.0 1.3 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 ORX58071.1 - 7e-08 32.6 0.2 1.4e-07 31.6 0.2 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 ORX58071.1 - 0.0043 17.1 0.1 0.0092 16.1 0.1 1.5 1 0 0 1 1 1 1 CH-like domain in sperm protein PAP2 PF01569.21 ORX58072.1 - 9e-15 54.6 14.3 5.1e-14 52.2 7.2 2.5 1 1 2 3 3 3 2 PAP2 superfamily DUF212 PF02681.14 ORX58072.1 - 0.034 14.3 1.7 0.26 11.4 0.2 2.2 1 1 1 2 2 2 0 Divergent PAP2 family TauE PF01925.19 ORX58072.1 - 0.035 13.7 7.0 0.14 11.7 2.9 2.1 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE PAXNEB PF05625.11 ORX58073.1 - 1.4e-94 317.3 0.0 1.7e-94 317.0 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein ATPase PF06745.13 ORX58073.1 - 0.00058 19.3 0.0 0.00084 18.8 0.0 1.2 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 ORX58073.1 - 0.073 12.3 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Rad51 Glyco_transf_34 PF05637.12 ORX58074.1 - 1.7e-21 77.1 0.1 5.5e-21 75.4 0.1 1.8 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 ORX58074.1 - 4.7e-10 39.4 0.0 2.6e-09 37.0 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function, DUF273 Nucleotid_trans PF03407.16 ORX58074.1 - 0.0055 16.7 0.1 0.0094 15.9 0.1 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Zip PF02535.22 ORX58074.1 - 0.17 11.1 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4719 PF15843.5 ORX58074.1 - 5.5 7.0 5.0 32 4.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4719) PTR2 PF00854.21 ORX58075.1 - 6.6e-87 291.9 9.2 1.4e-86 290.9 9.2 1.5 1 1 0 1 1 1 1 POT family FHA PF00498.26 ORX58076.1 - 6e-15 55.3 0.1 1.1e-14 54.5 0.1 1.5 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ORX58076.1 - 4.3e-13 48.8 5.7 8.4e-13 47.8 5.7 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX58076.1 - 3.2e-10 40.2 7.1 6.9e-10 39.1 7.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX58076.1 - 9.4e-05 22.2 7.8 0.00026 20.8 7.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX58076.1 - 0.00014 22.1 3.3 0.00014 22.1 3.3 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX58076.1 - 0.00022 21.0 6.2 0.00045 20.0 6.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX58076.1 - 0.00037 20.5 2.9 0.00072 19.6 2.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ORX58076.1 - 0.00051 20.0 6.3 0.0012 18.8 6.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX58076.1 - 0.00081 19.2 5.0 0.0018 18.1 5.0 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Yop-YscD_cpl PF16697.5 ORX58076.1 - 0.0032 17.8 0.0 0.013 15.8 0.0 1.8 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain PHD PF00628.29 ORX58076.1 - 0.0055 16.6 2.3 0.0095 15.8 2.3 1.4 1 0 0 1 1 1 1 PHD-finger zf-RING_UBOX PF13445.6 ORX58076.1 - 0.013 15.6 8.1 0.031 14.3 8.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ORX58076.1 - 0.24 11.0 4.9 0.16 11.6 2.6 1.9 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type RP-C_C PF11800.8 ORX58076.1 - 0.31 11.1 2.6 0.15 12.1 0.3 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region PRCC PF10253.9 ORX58077.1 - 1.4e-17 65.3 16.0 1.4e-17 65.3 16.0 2.2 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting DUF3085 PF11284.8 ORX58077.1 - 0.096 13.0 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3085) SMAP PF15477.6 ORX58077.1 - 0.95 10.5 4.3 0.34 11.9 0.6 2.3 2 0 0 2 2 2 0 Small acidic protein family TFIIE-A_C PF11521.8 ORX58077.1 - 1.7 9.0 15.2 1.4 9.3 0.4 3.6 3 1 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha FAM176 PF14851.6 ORX58077.1 - 3.4 7.3 6.3 2.8 7.6 1.3 2.6 2 0 0 2 2 2 0 FAM176 family EspB_PE PF18625.1 ORX58077.1 - 7 7.2 16.1 0.88 10.1 1.5 3.4 3 0 0 3 3 3 0 ESX-1 secreted protein B PE domain Ribosomal_S2 PF00318.20 ORX58078.1 - 6.1e-63 211.9 0.0 1.6e-35 122.3 0.0 2.1 2 0 0 2 2 2 2 Ribosomal protein S2 RNA_pol_N PF01194.17 ORX58079.1 - 2.8e-33 114.0 0.3 3.2e-33 113.8 0.3 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit HMGL-like PF00682.19 ORX58080.1 - 1.1e-58 198.8 0.0 1.4e-58 198.5 0.0 1.1 1 0 0 1 1 1 1 HMGL-like tRNA_int_endo PF01974.17 ORX58081.1 - 5.1e-21 74.5 0.1 1.1e-20 73.4 0.1 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 ORX58081.1 - 5.4e-05 22.8 0.0 0.0033 17.1 0.0 2.2 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain DSS1_SEM1 PF05160.13 ORX58082.1 - 8.5e-22 77.0 22.2 1e-21 76.7 22.2 1.1 1 0 0 1 1 1 1 DSS1/SEM1 family DUF2947 PF11163.8 ORX58082.1 - 0.036 13.9 5.8 0.041 13.7 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Cwf_Cwc_15 PF04889.12 ORX58082.1 - 0.53 10.0 9.8 0.58 9.8 9.8 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SNAP PF14938.6 ORX58083.1 - 2.6e-90 302.7 23.5 3e-90 302.5 23.5 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 ORX58083.1 - 1.3e-06 28.5 18.1 0.0017 18.6 8.4 3.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX58083.1 - 3.9e-05 24.0 17.7 3.1 8.6 0.4 6.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX58083.1 - 0.00021 21.2 22.8 1.2 9.5 0.0 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX58083.1 - 0.0027 17.6 11.3 2.5 8.3 0.0 5.4 3 2 1 4 4 4 2 Tetratricopeptide repeat Lyase_8_N PF08124.11 ORX58083.1 - 0.01 14.8 2.0 0.013 14.5 0.8 1.7 1 1 1 2 2 2 0 Polysaccharide lyase family 8, N terminal alpha-helical domain USP8_dimer PF08969.11 ORX58083.1 - 0.025 14.7 0.8 0.41 10.8 0.0 2.8 1 1 2 3 3 3 0 USP8 dimerisation domain NSF PF02071.20 ORX58083.1 - 0.053 14.2 22.2 0.37 11.7 0.3 6.7 6 1 2 8 8 7 0 Aromatic-di-Alanine (AdAR) repeat FATC PF02260.20 ORX58083.1 - 0.13 12.1 0.1 2.6 8.0 0.1 2.5 2 0 0 2 2 2 0 FATC domain PCRF PF03462.18 ORX58083.1 - 0.24 11.3 4.6 1.4 8.7 1.1 2.5 1 1 2 3 3 3 0 PCRF domain DUF410 PF04190.13 ORX58083.1 - 0.35 10.6 7.6 0.83 9.4 7.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF410) TPR_1 PF00515.28 ORX58083.1 - 2 8.4 18.1 13 5.8 0.1 5.8 5 2 1 6 6 6 0 Tetratricopeptide repeat FliS PF02561.14 ORX58083.1 - 2.5 8.4 6.8 4.4 7.6 0.5 3.2 1 1 2 3 3 3 0 Flagellar protein FliS Med9 PF07544.13 ORX58084.1 - 0.019 15.0 6.1 0.019 15.0 6.1 3.0 2 2 1 3 3 2 0 RNA polymerase II transcription mediator complex subunit 9 GldM_C PF12080.8 ORX58084.1 - 0.69 10.1 5.1 3.4 7.9 0.4 2.2 2 0 0 2 2 2 0 GldM C-terminal domain Alpha_Helical PF18489.1 ORX58084.1 - 1.1 9.4 9.5 0.14 12.3 3.3 2.1 2 0 0 2 2 2 0 Alpha helical domain MCU PF04678.13 ORX58084.1 - 1.7 8.7 18.6 0.55 10.3 6.2 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter zf-CCCH_6 PF18585.1 ORX58084.1 - 2.1 8.3 4.4 7 6.6 0.2 3.3 3 1 0 3 3 3 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 RACo_linker PF17650.1 ORX58084.1 - 3.9 7.4 7.1 1 9.3 0.3 3.1 2 2 0 3 3 3 0 RACo linker region Fez1 PF06818.15 ORX58084.1 - 5.2 7.5 32.6 0.24 11.8 25.3 2.0 1 1 1 2 2 2 0 Fez1 Barttin PF15462.6 ORX58084.1 - 6.8 6.4 10.6 0.32 10.8 3.3 2.0 1 1 1 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Hydrolase_6 PF13344.6 ORX58085.1 - 4.7e-28 97.3 0.0 8e-28 96.5 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX58085.1 - 2.4e-15 56.4 0.0 4.7e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD_2 PF13419.6 ORX58085.1 - 5e-05 23.5 0.0 0.0087 16.2 0.0 2.3 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX58085.1 - 5.4e-05 23.6 0.0 0.0005 20.4 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1358 PF07096.11 ORX58086.1 - 0.012 15.6 0.6 0.019 15.0 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1358) Sel1 PF08238.12 ORX58087.1 - 1.4e-40 136.8 22.1 7.2e-08 32.9 0.0 7.3 7 0 0 7 7 7 7 Sel1 repeat TPR_8 PF13181.6 ORX58087.1 - 0.42 10.9 2.6 94 3.6 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX58087.1 - 0.64 10.8 14.7 1.2 9.9 0.2 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat YL1 PF05764.13 ORX58088.1 - 0.12 12.5 12.6 0.14 12.2 12.6 1.2 1 0 0 1 1 1 0 YL1 nuclear protein RXT2_N PF08595.11 ORX58088.1 - 0.16 12.0 4.8 0.26 11.3 4.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal SDA1 PF05285.12 ORX58088.1 - 0.55 9.6 7.2 0.62 9.4 7.2 1.1 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 ORX58088.1 - 0.6 9.2 17.1 0.81 8.8 17.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ORX58088.1 - 1.2 7.2 13.7 1.7 6.7 13.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ORX58088.1 - 1.3 7.2 8.7 1.4 7.1 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ORX58088.1 - 1.3 7.1 9.9 1.5 6.9 9.9 1.1 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.8 ORX58088.1 - 4.8 6.2 15.7 6.9 5.7 15.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein WD40 PF00400.32 ORX58089.1 - 2e-47 158.2 19.2 1.8e-07 31.7 0.2 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58089.1 - 3.2e-27 94.6 2.7 6.9e-05 23.1 0.0 6.4 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX58089.1 - 2e-05 24.1 0.0 0.0054 16.1 0.0 3.7 2 1 0 3 3 3 1 WD40-like domain Nucleoporin_N PF08801.11 ORX58089.1 - 0.016 14.0 0.1 1.7 7.3 0.1 2.3 2 0 0 2 2 2 0 Nup133 N terminal like Nbas_N PF15492.6 ORX58089.1 - 0.034 13.5 0.0 2.3 7.5 0.0 2.9 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal RAB3GAP2_N PF14655.6 ORX58089.1 - 0.082 12.2 0.0 0.26 10.5 0.0 1.8 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Vps16_N PF04841.13 ORX58089.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.2 1 0 0 1 1 1 0 Vps16, N-terminal region LisH PF08513.11 ORX58090.1 - 1.3e-07 31.3 0.1 2.3e-07 30.5 0.1 1.5 1 0 0 1 1 1 1 LisH GrpE PF01025.19 ORX58091.1 - 3.3e-50 170.0 2.8 4.1e-50 169.7 2.8 1.1 1 0 0 1 1 1 1 GrpE NPH3 PF03000.14 ORX58091.1 - 0.058 13.0 0.4 0.082 12.5 0.4 1.3 1 0 0 1 1 1 0 NPH3 family Reprolysin_5 PF13688.6 ORX58092.1 - 2.6e-41 142.0 2.9 2.6e-41 142.0 2.9 2.3 3 1 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 ORX58092.1 - 2.1e-39 135.3 0.4 3.7e-39 134.5 0.4 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_2 PF13574.6 ORX58092.1 - 3.8e-39 134.6 0.4 1e-38 133.2 0.4 1.8 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 ORX58092.1 - 1.6e-15 57.7 27.7 1.6e-15 57.7 27.7 4.5 3 1 0 3 3 3 1 Disintegrin Reprolysin_3 PF13582.6 ORX58092.1 - 1.2e-14 54.9 0.5 3.3e-14 53.4 0.0 2.1 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Pep_M12B_propep PF01562.19 ORX58092.1 - 1.1e-05 25.6 0.0 2.8e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Reprolysin family propeptide Reprolysin PF01421.19 ORX58092.1 - 0.00019 21.4 3.1 0.001 19.0 3.1 2.3 1 1 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease ADAM_CR_2 PF17771.1 ORX58092.1 - 0.0024 18.4 13.2 0.0024 18.4 13.2 3.7 2 1 1 3 3 3 1 ADAM cysteine-rich domain Glycos_transf_1 PF00534.20 ORX58094.1 - 2.5e-29 102.0 0.0 3.7e-29 101.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX58094.1 - 1.3e-25 90.4 0.0 2.4e-25 89.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX58094.1 - 1.2e-18 67.7 1.2 2.8e-18 66.5 0.4 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX58094.1 - 4.1e-06 27.3 3.9 7.3e-06 26.5 0.2 2.2 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ORX58094.1 - 6.1e-05 23.3 0.1 0.00023 21.5 0.1 1.9 1 1 0 1 1 1 1 Glycosyl transferases group 1 NAGidase PF07555.13 ORX58094.1 - 0.086 12.2 0.1 0.17 11.2 0.1 1.5 2 0 0 2 2 2 0 beta-N-acetylglucosaminidase Pkinase PF00069.25 ORX58096.1 - 3e-66 223.5 0.0 3.6e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58096.1 - 3.9e-47 160.7 0.0 5e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX58096.1 - 9.5e-07 27.9 0.1 1.3e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX58096.1 - 1.1e-06 28.1 0.1 1.2e-05 24.8 0.0 2.2 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 ORX58096.1 - 0.00036 20.2 0.0 0.00072 19.2 0.0 1.4 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ORX58096.1 - 0.0023 16.9 1.0 0.0081 15.1 1.0 1.7 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX58096.1 - 0.009 16.0 0.0 0.046 13.6 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX58096.1 - 0.11 11.9 0.1 0.22 10.8 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PTPlike_phytase PF14566.6 ORX58097.1 - 3e-136 449.8 0.3 2.9e-48 163.9 0.0 3.6 3 0 0 3 3 3 3 Inositol hexakisphosphate DSPc PF00782.20 ORX58097.1 - 1.9e-07 31.0 0.0 0.23 11.3 0.0 4.3 4 0 0 4 4 4 3 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX58097.1 - 0.00046 19.8 0.0 5.2 6.6 0.0 3.5 3 0 0 3 3 3 2 Protein-tyrosine phosphatase Tropomyosin_1 PF12718.7 ORX58097.1 - 0.089 12.9 0.0 0.35 11.0 0.0 2.0 1 0 0 1 1 1 0 Tropomyosin like SDF PF00375.18 ORX58098.1 - 5.7e-82 275.8 28.0 6.8e-82 275.5 28.0 1.0 1 0 0 1 1 1 1 Sodium:dicarboxylate symporter family Diacid_rec PF05651.13 ORX58098.1 - 0.093 12.4 0.1 2 8.1 0.1 2.3 2 0 0 2 2 2 0 Putative sugar diacid recognition RhodobacterPufX PF11511.8 ORX58098.1 - 0.23 11.1 2.9 22 4.7 0.8 3.2 2 0 0 2 2 2 0 Intrinsic membrane protein PufX HMG_box PF00505.19 ORX58101.1 - 0.00011 22.5 0.3 0.00011 22.5 0.3 1.7 1 1 1 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX58101.1 - 0.0044 17.6 0.2 0.0044 17.6 0.2 1.7 1 1 1 2 2 2 1 HMG-box domain Ribosomal_L30 PF00327.20 ORX58102.1 - 2.9e-08 33.5 0.1 7.8e-08 32.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e GNAT_acetyltran PF12746.7 ORX58102.1 - 0.0005 19.7 0.4 0.00095 18.8 0.0 1.5 2 0 0 2 2 2 1 GNAT acetyltransferase JIP_LZII PF16471.5 ORX58102.1 - 0.0095 16.1 0.9 0.031 14.4 0.6 2.1 1 1 0 1 1 1 1 JNK-interacting protein leucine zipper II Gal-3-0_sulfotr PF06990.11 ORX58102.1 - 0.032 13.1 0.2 0.046 12.6 0.2 1.3 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase DUF2972 PF11186.8 ORX58102.1 - 0.097 12.6 2.0 0.65 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) Arf PF00025.21 ORX58103.1 - 3.6e-75 251.2 0.1 5.1e-73 244.2 0.1 2.0 1 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ORX58103.1 - 5.4e-14 52.4 0.1 1.2e-13 51.3 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ORX58103.1 - 4.5e-13 49.1 0.9 4.9e-09 35.8 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX58103.1 - 1.2e-12 47.7 0.0 1.6e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ORX58103.1 - 2.5e-12 46.7 0.0 3.1e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ORX58103.1 - 5.9e-11 42.2 0.0 7.3e-11 41.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX58103.1 - 1.4e-05 25.1 0.0 2.2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ORX58103.1 - 0.0095 15.3 0.2 0.019 14.3 0.1 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase cobW PF02492.19 ORX58103.1 - 0.19 11.3 0.2 1.2 8.7 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain TPR_1 PF00515.28 ORX58104.1 - 3.9e-16 58.1 11.0 0.00033 20.4 0.1 8.8 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX58104.1 - 1.4e-15 57.5 13.3 0.014 15.9 0.9 7.0 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ORX58104.1 - 1.4e-13 49.8 17.9 0.17 12.0 0.1 9.9 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_14 PF13428.6 ORX58104.1 - 1.2e-10 41.2 18.8 0.084 13.7 0.3 8.1 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX58104.1 - 5.2e-10 39.8 12.9 0.31 11.7 0.7 6.5 5 2 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX58104.1 - 5.9e-10 38.6 17.2 0.79 10.1 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX58104.1 - 1.2e-08 34.5 8.1 1.1 9.0 0.2 7.4 7 1 1 8 8 8 2 TPR repeat TPR_12 PF13424.6 ORX58104.1 - 4.3e-08 33.3 18.7 0.018 15.3 0.1 6.0 5 0 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX58104.1 - 1.7e-07 31.3 12.1 0.0021 18.2 1.3 5.7 6 0 0 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ORX58104.1 - 5.4e-06 26.1 12.1 0.93 9.7 0.3 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX58104.1 - 0.00016 21.8 4.1 40 4.9 0.0 6.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX58104.1 - 0.00025 20.8 11.0 0.033 14.1 0.4 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX58104.1 - 0.00039 20.5 6.2 5.2 7.3 0.1 5.7 5 2 1 6 6 6 1 Tetratricopeptide repeat DUF3856 PF12968.7 ORX58104.1 - 0.0015 18.6 0.1 0.0087 16.1 0.1 2.4 2 0 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_4 PF07721.14 ORX58104.1 - 0.0042 17.6 0.2 26 5.8 0.0 5.4 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 ORX58104.1 - 0.1 12.6 0.0 4.4 7.4 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ORX58104.1 - 4.3 7.7 10.5 14 6.1 0.2 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Ribosomal_S27 PF01599.19 ORX58105.1 - 7.9e-27 93.2 1.5 7.9e-27 93.2 1.5 2.0 3 0 0 3 3 3 1 Ribosomal protein S27a ubiquitin PF00240.23 ORX58105.1 - 2.5e-18 65.6 0.0 4.6e-18 64.7 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX58105.1 - 9.9e-08 31.7 0.0 1.7e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ORX58105.1 - 0.0039 17.2 0.0 2.6 8.2 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin-like domain Coilin_N PF15862.5 ORX58105.1 - 0.0093 15.8 0.0 0.013 15.3 0.0 1.1 1 0 0 1 1 1 1 Coilin N-terminus IBR PF01485.21 ORX58105.1 - 0.043 14.0 0.2 0.074 13.3 0.2 1.4 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Gpr1_Fun34_YaaH PF01184.19 ORX58106.1 - 1.1e-39 136.1 22.8 1.3e-39 135.9 22.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Gpr1_Fun34_YaaH PF01184.19 ORX58107.1 - 1.7e-19 70.2 19.8 2e-19 70.0 19.8 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family NIF PF03031.18 ORX58108.1 - 1.4e-12 47.7 0.0 2.3e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Nse4_C PF08743.10 ORX58109.1 - 2.5e-25 88.5 2.7 2.6e-25 88.5 0.0 2.4 3 0 0 3 3 3 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 ORX58109.1 - 4e-12 46.1 0.0 1e-11 44.7 0.0 1.7 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE DUF883 PF05957.13 ORX58109.1 - 0.17 12.5 0.7 0.4 11.3 0.7 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) CHIP_TPR_N PF18391.1 ORX58109.1 - 2.5 9.0 8.2 19 6.1 0.6 2.8 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain Enolase_C PF00113.22 ORX58110.1 - 2.8e-155 516.0 0.4 3.8e-155 515.5 0.4 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ORX58110.1 - 2e-57 193.0 0.2 3.3e-57 192.3 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ORX58110.1 - 0.00058 19.5 0.0 0.0013 18.4 0.0 1.5 1 1 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ORX58110.1 - 0.00065 18.9 0.4 0.0013 17.9 0.4 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus OrfB_Zn_ribbon PF07282.11 ORX58111.1 - 0.0004 20.2 0.1 0.00068 19.5 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Aldo_ket_red PF00248.21 ORX58112.1 - 6.8e-26 91.1 0.0 1.1e-24 87.1 0.0 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family KilA-N PF04383.13 ORX58113.1 - 0.00093 19.0 0.0 0.0026 17.6 0.0 1.7 1 1 0 1 1 1 1 KilA-N domain RNase_T PF00929.24 ORX58115.1 - 4e-15 56.8 0.0 1.3e-14 55.1 0.0 1.9 2 0 0 2 2 2 1 Exonuclease DNA_pol_A_exo1 PF01612.20 ORX58115.1 - 0.01 15.6 0.0 0.039 13.7 0.0 2.0 1 1 0 1 1 1 0 3'-5' exonuclease CAF1 PF04857.20 ORX58115.1 - 1.9 7.6 0.0 1.9 7.6 0.0 2.9 1 1 1 3 3 3 0 CAF1 family ribonuclease FR47 PF08445.10 ORX58116.1 - 5.6e-07 29.4 0.0 1e-06 28.6 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 ORX58116.1 - 1.8e-06 28.2 0.0 2.8e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 ORX58116.1 - 5.6e-06 27.1 0.1 1.5e-05 25.7 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX58116.1 - 6.9e-06 26.0 0.1 1.1e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX58116.1 - 2.5e-05 24.6 0.1 4.2e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ORX58116.1 - 0.0002 21.6 0.0 0.0003 21.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ORX58116.1 - 0.0018 18.0 0.0 0.023 14.4 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ORX58116.1 - 0.014 15.4 0.1 0.02 14.9 0.1 1.5 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX58116.1 - 0.017 15.2 0.1 0.029 14.5 0.1 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase CNH PF00780.22 ORX58117.1 - 3.5e-48 164.6 0.0 5.2e-48 164.0 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX58117.1 - 2.9e-37 128.7 0.9 5e-37 127.9 0.9 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX58117.1 - 2.2e-15 57.0 0.0 1.7e-13 50.9 0.0 2.7 1 1 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ORX58117.1 - 1.7e-11 44.0 0.0 3.3e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ApbA PF02558.16 ORX58118.1 - 8.4e-25 87.2 0.0 1.7e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX58118.1 - 1.1e-23 83.8 0.1 2e-23 83.0 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ORX58119.1 - 1.7e-30 105.6 0.0 2.4e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 ORX58119.1 - 2.5e-30 105.3 0.1 4.3e-30 104.5 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Ribosomal_S2 PF00318.20 ORX58120.1 - 6.8e-26 90.8 0.5 7.9e-13 48.1 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 ORX58120.1 - 0.009 17.4 21.8 0.013 16.8 5.1 2.3 1 1 1 2 2 2 1 40S ribosomal protein SA C-terminus Ribosomal_L27e PF01777.18 ORX58121.1 - 1.9e-37 127.5 7.3 1.9e-37 127.5 7.3 1.5 2 0 0 2 2 2 1 Ribosomal L27e protein family KOW PF00467.29 ORX58121.1 - 0.00068 19.5 4.0 0.0017 18.2 4.0 1.9 1 1 0 1 1 1 1 KOW motif GST_C_3 PF14497.6 ORX58122.1 - 6.4e-14 52.0 0.0 1.4e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX58122.1 - 0.0066 16.6 0.0 0.016 15.4 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX58122.1 - 0.013 15.8 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX58122.1 - 0.03 14.7 0.0 0.052 13.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX58122.1 - 0.066 13.2 0.0 0.19 11.8 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX58123.1 - 1.1e-10 41.6 0.0 2.1e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX58123.1 - 0.00064 19.9 0.0 0.0026 18.0 0.0 2.0 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX58123.1 - 0.0012 19.2 0.0 0.0024 18.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 ORX58123.1 - 0.0059 16.8 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin GST_N PF02798.20 ORX58123.1 - 0.0075 16.6 0.0 0.013 15.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 ORX58123.1 - 0.018 14.9 0.0 0.061 13.1 0.0 1.8 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX58123.1 - 0.025 14.9 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX58123.1 - 0.042 13.9 0.0 0.12 12.5 0.0 1.8 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX58124.1 - 4.4e-15 55.7 0.1 8.2e-15 54.8 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX58124.1 - 0.0056 16.9 0.1 0.018 15.3 0.0 1.9 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX58124.1 - 0.013 15.6 0.1 0.064 13.3 0.1 2.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Nif11 PF07862.11 ORX58124.1 - 0.041 14.2 0.1 0.098 13.0 0.1 1.7 1 0 0 1 1 1 0 Nif11 domain DUF3630 PF12305.8 ORX58124.1 - 0.042 13.9 0.2 0.066 13.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3630) LRR_4 PF12799.7 ORX58125.1 - 0.00028 21.2 4.2 1.4 9.5 0.0 4.7 3 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX58125.1 - 1.7 8.5 7.2 12 5.7 0.0 4.2 4 0 0 4 4 4 0 Leucine rich repeat GST_C_3 PF14497.6 ORX58126.1 - 5e-18 65.1 0.0 1.2e-17 64.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX58126.1 - 0.00033 20.8 0.0 0.00057 20.1 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX58126.1 - 0.036 14.1 0.0 0.11 12.5 0.0 1.9 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DUF1940 PF09155.10 ORX58126.1 - 0.052 13.7 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1940) DUF72 PF01904.18 ORX58126.1 - 0.12 12.4 0.1 0.48 10.5 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF72 MT-A70 PF05063.14 ORX58127.1 - 6.3e-38 130.4 0.0 1.1e-37 129.6 0.0 1.4 2 0 0 2 2 2 1 MT-A70 Cons_hypoth95 PF03602.15 ORX58127.1 - 0.047 13.3 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 UPF0020 PF01170.18 ORX58127.1 - 0.13 12.0 0.0 0.18 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Dynamin_M PF01031.20 ORX58130.1 - 4.2e-103 344.5 0.1 4.2e-103 344.5 0.1 1.7 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ORX58130.1 - 1.7e-54 184.4 0.0 3.4e-54 183.4 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ORX58130.1 - 7.3e-30 103.0 7.7 7.3e-30 103.0 7.7 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ORX58130.1 - 0.00058 19.9 0.6 0.0021 18.1 0.1 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase YajC PF02699.15 ORX58130.1 - 0.13 12.2 0.2 0.35 10.8 0.2 1.7 1 0 0 1 1 1 0 Preprotein translocase subunit W2 PF02020.18 ORX58130.1 - 0.21 11.7 2.6 1.1 9.4 2.6 2.2 1 1 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon AAA_15 PF13175.6 ORX58130.1 - 0.75 9.4 8.1 3.8 7.1 0.1 2.9 3 0 0 3 3 3 0 AAA ATPase domain Metal_resist PF13801.6 ORX58131.1 - 0.03 14.5 1.9 0.81 9.9 0.2 2.2 2 0 0 2 2 2 0 Heavy-metal resistance UCH PF00443.29 ORX58133.1 - 5.5e-56 189.9 1.3 8e-56 189.4 1.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX58133.1 - 8e-27 94.7 1.2 1.3e-26 94.0 1.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ORX58133.1 - 0.12 11.8 11.9 3.4 7.0 0.1 3.5 3 1 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Tnp_zf-ribbon_2 PF13842.6 ORX58133.1 - 0.75 10.7 7.5 19 6.2 1.6 3.3 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon SLC35F PF06027.12 ORX58134.1 - 6e-53 180.3 25.0 6.9e-53 180.1 25.0 1.0 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 ORX58134.1 - 3.7e-08 33.6 32.5 0.00014 22.1 15.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family CRT-like PF08627.10 ORX58134.1 - 2.4e-05 23.5 3.4 2.4e-05 23.5 3.4 1.6 1 1 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like She9_MDM33 PF05546.11 ORX58135.1 - 3.1e-66 223.0 11.9 4.6e-66 222.4 11.9 1.2 1 0 0 1 1 1 1 She9 / Mdm33 family OGFr_III PF04680.13 ORX58135.1 - 0.00044 20.7 2.4 0.00044 20.7 2.4 1.7 2 0 0 2 2 2 1 Opioid growth factor receptor repeat Tai4 PF16695.5 ORX58135.1 - 0.04 14.5 0.6 0.15 12.6 0.0 2.3 3 0 0 3 3 3 0 Type VI secretion system (T6SS), amidase immunity protein Baculo_gp64 PF03273.13 ORX58135.1 - 0.074 11.8 0.9 0.1 11.4 0.9 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family Ribosomal_S27e PF01667.17 ORX58136.1 - 9.4e-30 102.1 4.1 1.2e-29 101.8 4.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 ORX58136.1 - 0.00056 19.4 3.1 0.00083 18.8 3.1 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding IBR PF01485.21 ORX58136.1 - 0.019 15.1 0.7 0.029 14.6 0.7 1.3 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Prok-RING_1 PF14446.6 ORX58136.1 - 0.021 14.8 2.1 0.035 14.0 2.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C2HC5 PF06221.13 ORX58136.1 - 0.029 14.3 2.6 0.029 14.3 2.6 1.8 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type zinc_ribbon_4 PF13717.6 ORX58136.1 - 0.062 13.2 1.9 2 8.4 1.9 2.3 1 1 0 1 1 1 0 zinc-ribbon domain MFS_1 PF07690.16 ORX58137.1 - 2.2e-33 115.6 26.2 3.1e-33 115.2 26.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily OATP PF03137.20 ORX58137.1 - 1.4e-10 40.1 0.4 1.4e-10 40.1 0.4 1.5 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family GPHR_N PF12537.8 ORX58138.1 - 0.049 13.7 1.1 3.2 7.9 1.1 2.6 1 1 0 1 1 1 0 The Golgi pH Regulator (GPHR) Family N-terminal Ndc1_Nup PF09531.10 ORX58138.1 - 1.9 7.0 4.1 2.4 6.8 4.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SRP-alpha_N PF04086.13 ORX58138.1 - 2.2 8.2 7.8 3.2 7.6 7.8 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Spore_YhcN_YlaJ PF09580.10 ORX58138.1 - 3.8 7.6 9.4 0.61 10.2 2.9 2.2 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) SOG2 PF10428.9 ORX58138.1 - 9 5.4 12.2 12 4.9 12.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Syntaxin-6_N PF09177.11 ORX58139.1 - 0.2 12.2 1.8 0.25 11.9 0.5 1.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal vATP-synt_E PF01991.18 ORX58140.1 - 2e-58 197.1 9.8 2.3e-58 196.9 9.8 1.1 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit PMI_typeI PF01238.21 ORX58141.1 - 1e-128 429.7 0.0 1.3e-128 429.4 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I Imm53 PF15580.6 ORX58141.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 53 MFS_1 PF07690.16 ORX58142.1 - 6.3e-39 133.9 23.0 6.9e-39 133.8 23.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX58142.1 - 3e-15 56.1 6.5 4.5e-15 55.5 6.5 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_4 PF06779.14 ORX58142.1 - 0.00067 19.1 1.8 0.00067 19.1 1.8 1.6 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB TRI12 PF06609.13 ORX58142.1 - 0.00099 17.6 2.6 0.0013 17.2 2.6 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 ORX58142.1 - 0.0056 15.0 3.8 0.0082 14.5 3.2 1.6 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Transgly_assoc PF04226.13 ORX58142.1 - 0.025 14.8 5.9 0.025 14.8 5.9 2.6 2 0 0 2 2 2 0 Transglycosylase associated protein KCH PF16944.5 ORX58143.1 - 1.3e-69 234.8 13.0 1.5e-69 234.5 13.0 1.1 1 0 0 1 1 1 1 Fungal potassium channel UPF0242 PF06785.11 ORX58143.1 - 0.0095 16.1 0.0 0.014 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus zf-C2H2 PF00096.26 ORX58144.1 - 1.9e-17 62.6 17.3 4.9e-07 29.8 2.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX58144.1 - 1.9e-12 47.0 14.9 9.8e-06 25.8 0.2 4.5 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX58144.1 - 1.4e-11 44.2 12.8 9.4e-05 22.9 1.7 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX58144.1 - 1.6e-09 37.8 4.2 0.00054 20.2 0.2 3.5 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX58144.1 - 2.7e-08 33.6 7.0 0.016 15.2 0.1 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HE PF16278.5 ORX58144.1 - 7e-05 23.2 11.7 0.16 12.5 1.9 3.4 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 ORX58144.1 - 0.00028 21.2 7.1 0.14 12.6 0.2 3.7 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX58144.1 - 0.002 17.9 6.3 0.089 12.6 0.0 3.1 3 0 0 3 3 3 2 zinc-finger C2H2-type zf_ZIC PF18366.1 ORX58144.1 - 0.0081 16.2 1.0 13 6.0 0.0 3.5 2 1 1 3 3 3 0 Zic proteins zinc finger domain Zn-ribbon_8 PF09723.10 ORX58144.1 - 0.02 15.0 9.4 0.13 12.4 0.8 3.4 3 1 1 4 4 4 0 Zinc ribbon domain HypA PF01155.19 ORX58144.1 - 0.13 12.3 2.3 0.24 11.4 1.1 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-LYAR PF08790.11 ORX58144.1 - 0.19 11.6 2.4 12 5.9 0.0 3.5 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-BED PF02892.15 ORX58144.1 - 1.4 9.0 7.5 2.3 8.3 0.4 3.1 3 0 0 3 3 3 0 BED zinc finger zf-C2HC_2 PF13913.6 ORX58144.1 - 1.9 8.5 14.0 0.93 9.5 0.7 3.4 4 0 0 4 4 4 0 zinc-finger of a C2HC-type C1_4 PF07975.12 ORX58144.1 - 2.1 8.7 9.4 3.5 7.9 1.4 3.1 1 1 2 3 3 3 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 ORX58144.1 - 8.2 7.3 9.3 1.9 9.3 0.6 2.6 1 1 2 3 3 3 0 zinc-ribbon family Methyltransf_25 PF13649.6 ORX58145.1 - 8.5e-14 52.0 0.0 1.3e-11 45.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX58145.1 - 4.3e-13 49.7 0.0 8.4e-11 42.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX58145.1 - 1.2e-09 37.9 0.0 1.1e-07 31.4 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_31 PF13847.6 ORX58145.1 - 4.3e-07 29.8 0.0 7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX58145.1 - 9.4e-07 28.9 0.0 5.3e-06 26.5 0.0 2.0 1 1 0 2 2 2 1 Hypothetical methyltransferase MTS PF05175.14 ORX58145.1 - 0.00032 20.3 0.0 0.002 17.7 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 ORX58145.1 - 0.00056 20.6 0.0 0.0036 18.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX58145.1 - 0.00065 19.1 0.0 0.0014 18.0 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ORX58145.1 - 0.0028 17.5 0.0 0.0074 16.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX58145.1 - 0.0079 15.5 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain CMAS PF02353.20 ORX58145.1 - 0.014 14.7 0.0 0.022 14.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.12 ORX58145.1 - 0.11 12.0 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW eIF-1a PF01176.19 ORX58146.1 - 6.5e-23 80.3 0.1 1.2e-22 79.4 0.1 1.5 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 RRM_1 PF00076.22 ORX58147.1 - 7.4e-19 67.3 0.0 1.1e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Peptidase_M22 PF00814.25 ORX58148.1 - 1.3e-78 264.4 0.7 1.6e-78 264.2 0.7 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ORX58148.1 - 0.013 15.2 0.1 0.031 14.0 0.1 1.6 1 1 0 1 1 1 0 Carbamoyltransferase N-terminus Bystin PF05291.11 ORX58149.1 - 3.3e-136 453.3 0.1 3.3e-136 453.3 0.1 1.5 2 0 0 2 2 2 1 Bystin Pkinase PF00069.25 ORX58150.1 - 7.6e-52 176.3 0.0 1.5e-51 175.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58150.1 - 1.4e-39 135.9 0.0 2.3e-39 135.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 ORX58150.1 - 4.2e-05 23.7 0.2 9.5e-05 22.5 0.2 1.6 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Kinase-like PF14531.6 ORX58150.1 - 0.035 13.4 0.0 7.6 5.7 0.0 2.3 2 0 0 2 2 2 0 Kinase-like GH114_assoc PF14741.6 ORX58150.1 - 0.12 12.6 0.0 1.2 9.3 0.0 2.4 2 0 0 2 2 2 0 N-terminal glycosyl-hydrolase-114-associated domain ATF7IP_BD PF16788.5 ORX58150.1 - 0.23 11.5 1.6 0.45 10.6 1.6 1.4 1 0 0 1 1 1 0 ATF-interacting protein binding domain Aa_trans PF01490.18 ORX58151.1 - 2e-60 204.6 27.4 2e-60 204.6 27.4 1.5 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein CytB6-F_Fe-S PF08802.10 ORX58151.1 - 0.046 13.7 1.6 0.2 11.7 1.6 2.2 1 0 0 1 1 1 0 Cytochrome B6-F complex Fe-S subunit DUF2178 PF09946.9 ORX58151.1 - 0.09 13.0 0.1 0.09 13.0 0.1 3.4 2 1 2 4 4 4 0 Predicted membrane protein (DUF2178) MitMem_reg PF13012.6 ORX58152.1 - 4e-20 72.3 0.6 3.5e-19 69.3 0.1 2.1 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ORX58152.1 - 3.3e-15 56.1 0.0 6.3e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Disaggr_repeat PF06848.11 ORX58153.1 - 0.03 14.0 0.0 0.03 14.0 0.0 1.0 1 0 0 1 1 1 0 Disaggregatase related repeat HATPase_c PF02518.26 ORX58155.1 - 4.7e-30 104.4 0.1 9.4e-30 103.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX58155.1 - 7.2e-20 71.2 1.1 3.4e-19 69.1 0.0 2.8 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 ORX58155.1 - 7.3e-18 64.4 0.0 3.4e-17 62.2 0.0 2.3 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain AAA_16 PF13191.6 ORX58155.1 - 5.8e-17 62.6 0.0 3.7e-16 60.0 0.0 2.5 1 0 0 1 1 1 1 AAA ATPase domain Pkinase PF00069.25 ORX58155.1 - 4.1e-15 55.9 0.0 8.8e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58155.1 - 2e-08 33.8 0.0 4.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase GAF PF01590.26 ORX58155.1 - 5.6e-06 27.0 0.1 3.3e-05 24.5 0.0 2.5 2 0 0 2 2 2 1 GAF domain AAA_22 PF13401.6 ORX58155.1 - 0.0087 16.3 0.0 0.2 11.9 0.0 2.9 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX58155.1 - 0.013 15.4 0.7 1.1 9.1 0.0 3.5 3 0 0 3 3 3 0 NTPase RsgA_GTPase PF03193.16 ORX58155.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ORX58155.1 - 0.028 14.2 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX58155.1 - 0.029 14.3 4.0 0.06 13.3 0.5 3.2 3 1 0 3 3 3 0 NACHT domain AAA_29 PF13555.6 ORX58155.1 - 0.071 12.9 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Kinase-like PF14531.6 ORX58155.1 - 0.075 12.3 0.1 0.3 10.4 0.0 1.9 2 0 0 2 2 2 0 Kinase-like ABC_tran PF00005.27 ORX58155.1 - 0.081 13.4 0.0 0.35 11.4 0.0 2.0 2 0 0 2 2 2 0 ABC transporter NB-ARC PF00931.22 ORX58155.1 - 0.083 12.1 0.4 11 5.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain C2 PF00168.30 ORX58157.1 - 1.4e-10 41.4 0.0 1.7e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 C2 domain CCDC158 PF15921.5 ORX58157.1 - 0.096 10.5 0.0 0.11 10.3 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 Filament PF00038.21 ORX58158.1 - 0.0025 17.5 3.2 0.0038 16.9 3.2 1.2 1 0 0 1 1 1 1 Intermediate filament protein LOH1CR12 PF10158.9 ORX58158.1 - 0.0027 17.7 0.4 0.0058 16.7 0.4 1.5 1 0 0 1 1 1 1 Tumour suppressor protein Exonuc_VII_L PF02601.15 ORX58158.1 - 0.0089 15.6 4.2 0.015 14.9 4.2 1.3 1 0 0 1 1 1 1 Exonuclease VII, large subunit HemX PF04375.14 ORX58158.1 - 0.011 15.0 2.4 0.021 14.1 2.4 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DHR10 PF18595.1 ORX58158.1 - 0.016 15.3 5.7 0.031 14.3 5.7 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain YkyA PF10368.9 ORX58158.1 - 0.039 13.6 0.6 0.058 13.1 0.6 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein TACC_C PF05010.14 ORX58158.1 - 0.099 12.4 3.4 0.18 11.6 3.4 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2663 PF10864.8 ORX58158.1 - 0.12 12.8 0.8 0.36 11.3 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Fzo_mitofusin PF04799.13 ORX58158.1 - 0.21 11.1 3.1 0.48 10.0 3.1 1.6 1 0 0 1 1 1 0 fzo-like conserved region EzrA PF06160.12 ORX58158.1 - 0.21 9.7 2.7 0.29 9.3 2.7 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Occludin_ELL PF07303.13 ORX58158.1 - 0.25 12.1 2.6 0.64 10.8 2.6 1.7 1 0 0 1 1 1 0 Occludin homology domain Pkinase PF00069.25 ORX58159.1 - 3.1e-60 203.8 0.0 2.2e-39 135.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58159.1 - 3.6e-27 95.3 0.0 1.2e-21 77.2 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 ORX58159.1 - 4.2e-13 49.4 0.1 1e-12 48.2 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 ORX58159.1 - 0.0011 18.3 0.0 0.016 14.6 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ORX58159.1 - 0.0036 17.3 0.4 0.0096 15.9 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX58159.1 - 0.0054 15.7 0.0 0.014 14.4 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain F-box-like PF12937.7 ORX58160.1 - 5.8e-06 26.1 5.5 1e-05 25.3 3.6 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX58160.1 - 0.00069 19.4 4.5 0.00069 19.4 4.5 2.6 3 0 0 3 3 3 1 F-box domain Antimicrobial24 PF16049.5 ORX58160.1 - 0.18 11.8 0.1 0.35 10.9 0.1 1.3 1 0 0 1 1 1 0 Frog antimicrobial peptide LRR_4 PF12799.7 ORX58160.1 - 0.91 10.0 13.0 5.2 7.6 0.9 4.7 3 2 1 4 4 4 0 Leucine Rich repeats (2 copies) MBOAT PF03062.19 ORX58161.1 - 4.9e-37 128.1 22.3 1e-36 127.0 22.3 1.6 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family HA2 PF04408.23 ORX58161.1 - 1.8e-20 73.3 0.0 5.4e-20 71.7 0.0 1.9 1 1 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX58161.1 - 3.2e-09 37.0 0.0 1.6e-08 34.8 0.0 2.3 1 1 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX58161.1 - 4e-08 33.6 0.0 9.2e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ORX58161.1 - 0.0061 16.3 0.1 0.013 15.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Pkinase PF00069.25 ORX58162.1 - 1.9e-46 158.6 0.0 2.7e-46 158.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58162.1 - 3e-18 66.0 0.0 4.3e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX58162.1 - 0.0046 16.9 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX58162.1 - 0.067 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Arrestin_C PF02752.22 ORX58163.1 - 5e-10 39.9 0.4 5.8e-09 36.5 0.1 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX58163.1 - 2.5e-06 27.6 0.0 5.3e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX58163.1 - 0.0026 17.5 0.1 0.025 14.3 0.0 2.2 1 1 1 2 2 2 1 Arrestin_N terminal like FixH PF05751.11 ORX58163.1 - 0.025 14.6 0.2 0.041 13.9 0.2 1.3 1 0 0 1 1 1 0 FixH Pheromone PF08015.11 ORX58163.1 - 2.5 9.2 6.4 20 6.3 6.4 2.5 1 1 0 1 1 1 0 Fungal mating-type pheromone Motile_Sperm PF00635.26 ORX58164.1 - 3e-26 91.4 0.2 7.6e-26 90.1 0.2 1.7 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 ORX58164.1 - 0.0061 16.7 0.3 0.015 15.5 0.3 1.7 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PikAIV_N PF18605.1 ORX58164.1 - 0.054 13.1 0.4 0.054 13.1 0.4 4.2 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain FtsL PF04999.13 ORX58164.1 - 0.075 13.0 30.3 0.058 13.4 0.9 5.1 1 1 4 5 5 5 0 Cell division protein FtsL KASH_CCD PF14662.6 ORX58164.1 - 0.13 12.0 49.5 0.14 12.0 12.2 3.6 2 1 2 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF812 PF05667.11 ORX58164.1 - 1.5 7.6 34.1 3 6.6 33.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) ECH_1 PF00378.20 ORX58166.1 - 1.4e-38 132.6 0.0 1.8e-38 132.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX58166.1 - 4e-16 59.5 0.0 4.8e-16 59.2 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Cg6151-P PF10233.9 ORX58167.1 - 1.1e-27 96.5 11.4 1.3e-27 96.3 11.4 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P MNSV_P7B PF06692.11 ORX58167.1 - 0.049 13.6 0.4 0.13 12.3 0.1 1.9 2 1 0 2 2 2 0 Melon necrotic spot virus P7B protein DUF5489 PF17592.2 ORX58167.1 - 0.052 14.1 2.3 0.052 14.1 2.3 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5489) UbiA PF01040.18 ORX58167.1 - 1 8.6 13.5 1.7 7.8 13.5 1.3 1 1 0 1 1 1 0 UbiA prenyltransferase family TrbC PF04956.13 ORX58167.1 - 3.2 8.0 13.0 4 7.7 7.9 2.1 2 0 0 2 2 2 0 TrbC/VIRB2 family DUF4133 PF13571.6 ORX58167.1 - 3.6 8.0 8.2 0.95 9.8 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Phage_holin_3_6 PF07332.11 ORX58167.1 - 3.9 7.5 9.7 0.99 9.5 0.5 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Rxt3 PF08642.10 ORX58168.1 - 3.8e-23 82.6 3.5 5.1e-23 82.2 0.1 2.6 2 0 0 2 2 2 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 ORX58168.1 - 0.02 15.0 0.0 0.38 10.9 0.0 2.2 2 0 0 2 2 2 0 LCCL domain HNF-1_N PF04814.13 ORX58168.1 - 1.2 9.7 5.1 0.43 11.2 1.7 1.9 1 1 1 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Ribosomal_L28e PF01778.17 ORX58169.1 - 1.9e-39 135.0 0.6 1.9e-39 135.0 0.6 2.1 3 0 0 3 3 3 1 Ribosomal L28e protein family Mak16 PF04874.14 ORX58169.1 - 5.1e-28 97.6 21.0 5.1e-28 97.6 21.0 2.4 2 0 0 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 ORX58169.1 - 0.086 12.2 18.1 0.11 11.8 18.1 1.1 1 0 0 1 1 1 0 BUD22 PYC_OADA PF02436.18 ORX58169.1 - 0.28 10.9 3.2 0.52 10.0 3.1 1.5 1 1 0 1 1 1 0 Conserved carboxylase domain Trypan_glycop PF00913.19 ORX58169.1 - 1.3 8.2 5.4 0.9 8.7 3.8 1.5 1 1 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Nop53 PF07767.11 ORX58169.1 - 6.6 6.0 35.0 0.69 9.2 18.2 2.1 1 1 1 2 2 2 0 Nop53 (60S ribosomal biogenesis) Mito_carr PF00153.27 ORX58170.1 - 4.7e-47 157.8 2.0 7.1e-19 67.5 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein PFK PF00365.20 ORX58171.1 - 6.4e-194 642.6 4.7 2.2e-105 352.0 3.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase DAGK_cat PF00781.24 ORX58171.1 - 0.12 12.0 0.1 0.74 9.4 0.1 2.3 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Kelch_6 PF13964.6 ORX58172.1 - 1.2e-15 57.2 0.8 0.0014 18.9 0.0 5.1 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 ORX58172.1 - 4.7e-15 55.2 0.0 0.0034 17.3 0.1 3.8 3 1 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ORX58172.1 - 6.6e-15 54.8 0.3 0.002 18.1 0.0 4.7 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX58172.1 - 7.9e-12 45.2 7.4 1.8e-08 34.5 0.0 6.1 7 0 0 7 7 7 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX58172.1 - 8.3e-11 41.4 0.2 0.026 14.5 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ORX58172.1 - 3e-10 39.5 0.2 0.0039 16.7 0.0 3.8 4 0 0 4 4 4 2 Kelch motif BTB PF00651.31 ORX58172.1 - 1.3e-09 38.3 0.7 0.00011 22.4 0.6 2.5 2 0 0 2 2 2 2 BTB/POZ domain RAG2 PF03089.14 ORX58172.1 - 0.0058 15.7 0.0 0.029 13.4 0.0 1.9 1 1 1 2 2 2 1 Recombination activating protein 2 CCDC14 PF15254.6 ORX58173.1 - 0.047 12.3 0.2 0.057 12.1 0.2 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 VAR1 PF05316.12 ORX58174.1 - 4.4e-07 29.3 5.8 3.6e-05 23.0 0.7 3.3 2 2 1 3 3 3 2 Mitochondrial ribosomal protein (VAR1) Ribosomal_S3_C PF00189.20 ORX58174.1 - 6.9e-07 29.7 0.0 1.1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S3, C-terminal domain zf_CCCH_4 PF18345.1 ORX58175.1 - 8e-06 25.7 7.8 1.3e-05 25.0 7.8 1.4 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ORX58175.1 - 1.3e-05 25.9 0.5 2e-05 25.2 0.5 1.3 1 0 0 1 1 1 1 Torus domain zf-CCCH PF00642.24 ORX58175.1 - 1.6e-05 24.7 4.4 2.6e-05 24.0 4.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ORX58175.1 - 4.9e-05 23.0 3.7 7.5e-05 22.4 3.7 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX58175.1 - 0.00075 19.9 2.9 0.0017 18.8 2.9 1.6 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 ORX58175.1 - 0.074 13.3 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger containing family RNB PF00773.19 ORX58176.1 - 5.1e-80 269.3 0.1 8.2e-80 268.6 0.1 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX58176.1 - 9.9e-21 73.6 0.0 2.5e-20 72.3 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ORX58176.1 - 4.7e-14 52.5 0.2 1.6e-13 50.8 0.2 1.9 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal RNase_II_C_S1 PF18614.1 ORX58176.1 - 1.4 8.9 4.9 15 5.6 0.2 2.8 3 0 0 3 3 3 0 RNase II-type exonuclease C-terminal S1 domain NTP_transferase PF00483.23 ORX58177.1 - 2.8e-16 59.8 0.0 6.1e-16 58.7 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ORX58177.1 - 5.6e-08 33.3 0.0 7.7e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain EIIBC-GUT_N PF03612.14 ORX58177.1 - 0.079 12.7 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Pkinase PF00069.25 ORX58177.1 - 0.09 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain RhoGAP PF00620.27 ORX58178.1 - 1e-48 165.0 0.1 4.3e-47 159.8 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 ORX58178.1 - 1.1e-14 54.4 3.2 1.5e-14 54.0 0.4 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain AEP1 PF17049.5 ORX58178.1 - 0.025 13.7 0.1 0.05 12.7 0.1 1.4 1 0 0 1 1 1 0 ATPase expression protein 1 LRS4 PF10422.9 ORX58178.1 - 0.13 11.9 5.6 0.11 12.1 4.3 1.5 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 Ytp1 PF10355.9 ORX58178.1 - 0.15 11.3 0.4 0.25 10.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (Ytp1) Adhesin_P1_N PF18652.1 ORX58178.1 - 1.6 8.8 14.3 1.1 9.3 0.1 3.6 3 0 0 3 3 3 0 Adhesin P1 N-terminal domain 2-oxoacid_dh PF00198.23 ORX58179.1 - 3.3e-72 242.7 0.1 5.1e-72 242.1 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ORX58179.1 - 2.2e-17 62.6 0.0 4.5e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 ORX58179.1 - 1.6e-15 57.2 0.1 3.6e-15 56.0 0.1 1.7 1 0 0 1 1 1 1 e3 binding domain SF3b10 PF07189.11 ORX58180.1 - 9.3e-37 125.0 0.0 1.1e-36 124.7 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) HTH_19 PF12844.7 ORX58180.1 - 0.027 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain P22_AR_C PF10548.9 ORX58180.1 - 0.11 12.7 0.1 0.44 10.7 0.0 1.8 1 1 1 2 2 2 0 P22AR C-terminal domain OPT PF03169.15 ORX58182.1 - 1.5e-186 621.8 53.0 1.7e-186 621.6 53.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.16 ORX58183.1 - 1.1e-13 50.8 36.0 2e-13 50.0 36.0 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ORX58183.1 - 1.2e-10 41.3 4.7 1.2e-10 41.3 4.7 2.6 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF4149 PF13664.6 ORX58183.1 - 0.025 14.9 1.2 0.025 14.9 1.2 3.6 4 1 1 5 5 5 0 Domain of unknown function (DUF4149) UCR_UQCRX_QCR9 PF05365.12 ORX58183.1 - 0.23 11.4 0.1 0.23 11.4 0.1 3.0 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like RPE65 PF03055.15 ORX58184.1 - 7.4e-82 276.0 0.1 9.7e-82 275.6 0.1 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Rtt106 PF08512.12 ORX58185.1 - 4.7e-23 81.4 0.0 1.3e-22 80.0 0.0 1.8 2 0 0 2 2 2 1 Histone chaperone Rttp106-like PH_18 PF18469.1 ORX58185.1 - 0.0028 17.7 0.1 0.0071 16.3 0.1 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain SseB PF07179.12 ORX58185.1 - 0.056 13.7 0.1 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 SseB protein N-terminal domain Acyltransferase PF01553.21 ORX58186.1 - 1.6e-22 79.6 0.0 2.4e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 ORX58186.1 - 1.2e-15 57.3 0.2 2.6e-15 56.3 0.2 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus Tma16 PF11176.8 ORX58187.1 - 6.3e-37 126.7 4.7 7.9e-37 126.4 4.7 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 AAA PF00004.29 ORX58189.1 - 1.2e-41 142.3 0.0 2.9e-41 141.0 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX58189.1 - 1.1e-08 34.8 0.1 2.6e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX58189.1 - 1.9e-05 24.7 0.1 9.1e-05 22.5 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX58189.1 - 9.2e-05 22.7 0.0 0.0053 17.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX58189.1 - 0.0001 22.7 0.1 0.0019 18.6 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ORX58189.1 - 0.0002 21.6 0.0 0.00083 19.5 0.0 2.1 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ORX58189.1 - 0.00057 19.1 0.0 0.001 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 ORX58189.1 - 0.0024 17.6 0.0 0.0064 16.2 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ORX58189.1 - 0.011 15.3 0.0 0.025 14.1 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 ORX58189.1 - 0.014 15.6 0.0 0.026 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX58189.1 - 0.021 15.0 0.0 0.04 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ORX58189.1 - 0.028 14.3 0.9 5.5 6.8 0.0 2.9 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ORX58189.1 - 0.03 14.7 0.0 0.096 13.1 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_3 PF07726.11 ORX58189.1 - 0.034 14.0 0.0 0.069 13.0 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ORX58189.1 - 0.039 13.7 0.1 0.12 12.0 0.0 1.9 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.13 ORX58189.1 - 0.044 13.0 0.0 0.094 11.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_18 PF13238.6 ORX58189.1 - 0.056 14.0 0.0 0.14 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ORX58189.1 - 0.059 12.7 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 ORX58189.1 - 0.076 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Sigma54_activat PF00158.26 ORX58189.1 - 0.092 12.4 0.0 0.22 11.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 ORX58189.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ORX58189.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein DNA_pol_E_B PF04042.16 ORX58190.1 - 2.2e-45 154.6 0.0 3.5e-45 154.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 ORX58190.1 - 1.5e-39 135.0 0.0 3.3e-39 134.0 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain MMS1_N PF10433.9 ORX58192.1 - 4e-71 240.1 0.5 8.1e-71 239.1 0.5 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ORX58192.1 - 2e-56 191.7 1.5 4.4e-56 190.6 0.0 2.4 4 0 0 4 4 4 1 CPSF A subunit region DUF620 PF04788.12 ORX58192.1 - 0.15 11.5 0.0 0.3 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF620) Pyridox_oxase_2 PF12766.7 ORX58193.1 - 1.2e-14 54.7 0.0 2.3e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ORX58193.1 - 0.053 13.7 0.0 0.091 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase eIF-6 PF01912.18 ORX58194.1 - 7.1e-84 280.1 0.3 9.9e-84 279.6 0.3 1.2 1 0 0 1 1 1 1 eIF-6 family 4HBT PF03061.22 ORX58195.1 - 2.7e-07 30.8 0.0 1.5e-06 28.4 0.0 1.9 2 0 0 2 2 2 1 Thioesterase superfamily MHC_II_beta PF00969.19 ORX58195.1 - 0.0085 16.2 0.0 0.017 15.2 0.0 1.5 2 0 0 2 2 2 1 Class II histocompatibility antigen, beta domain 4HBT_3 PF13622.6 ORX58195.1 - 0.012 15.9 0.0 0.013 15.8 0.0 1.1 1 0 0 1 1 1 0 Thioesterase-like superfamily zf-Tim10_DDP PF02953.15 ORX58196.1 - 3.1e-25 87.6 1.5 3.6e-25 87.4 1.5 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger FBPase_2 PF06874.11 ORX58196.1 - 0.032 12.5 0.1 0.032 12.5 0.1 1.0 1 0 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Erf4 PF10256.9 ORX58196.1 - 0.042 14.0 0.1 0.09 12.9 0.1 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DNA_repr_REX1B PF14966.6 ORX58197.1 - 3.4e-24 85.3 8.8 4.4e-24 84.9 4.1 2.0 1 1 1 2 2 2 1 DNA repair REX1-B HSCB_C PF07743.13 ORX58197.1 - 0.7 10.4 13.5 2.7 8.5 3.5 3.0 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain CKS PF01111.19 ORX58198.1 - 3.4e-20 72.1 3.8 3.4e-20 72.1 3.8 2.0 3 0 0 3 3 3 1 Cyclin-dependent kinase regulatory subunit CDC14 PF08045.11 ORX58198.1 - 0.02 14.0 1.0 0.02 14.0 1.0 2.0 2 0 0 2 2 2 0 Cell division control protein 14, SIN component GTP_EFTU PF00009.27 ORX58199.1 - 9.2e-64 214.6 0.1 1.4e-63 214.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 ORX58199.1 - 9.8e-26 89.7 0.0 2e-25 88.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ORX58199.1 - 1.3e-17 63.6 0.0 3.3e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX58199.1 - 5.4e-08 33.1 0.2 3.7e-07 30.4 0.1 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ORX58199.1 - 4.1e-06 26.7 0.0 9.1e-06 25.5 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain EFG_IV PF03764.18 ORX58199.1 - 2.8e-05 23.9 0.2 0.0002 21.1 0.0 2.6 3 0 0 3 3 3 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 ORX58199.1 - 0.0035 17.4 0.0 0.01 15.9 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase UQ_con PF00179.26 ORX58200.1 - 5.9e-32 110.2 0.0 7e-32 110.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ORX58200.1 - 0.033 14.5 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain UFC1 PF08694.11 ORX58200.1 - 0.11 12.2 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Pterin_bind PF00809.22 ORX58203.1 - 8.4e-78 261.4 1.0 1.4e-77 260.7 0.3 1.8 2 0 0 2 2 2 1 Pterin binding enzyme FolB PF02152.18 ORX58203.1 - 6e-50 168.4 0.9 1.7e-23 83.3 0.0 2.7 2 0 0 2 2 2 2 Dihydroneopterin aldolase HPPK PF01288.20 ORX58203.1 - 1.5e-37 128.5 0.0 3.4e-37 127.4 0.0 1.6 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) AAA PF00004.29 ORX58204.1 - 1.2e-16 61.3 0.1 3.4e-16 59.9 0.0 1.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 ORX58204.1 - 7.5e-16 58.3 0.4 1.6e-15 57.2 0.4 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 ORX58204.1 - 1.8e-14 53.9 0.1 2.4e-12 46.9 0.1 2.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 ORX58204.1 - 1.3e-08 35.0 0.0 2.5e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_11 PF13086.6 ORX58204.1 - 6.8e-07 29.3 0.7 6.2e-06 26.2 0.0 2.4 2 1 0 3 3 2 1 AAA domain AAA_16 PF13191.6 ORX58204.1 - 3.6e-05 24.2 0.0 0.00061 20.2 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ORX58204.1 - 4.6e-05 23.7 0.1 0.0024 18.1 0.0 2.7 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ORX58204.1 - 5.6e-05 22.9 0.0 0.0002 21.2 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 ORX58204.1 - 0.00014 21.3 0.0 0.013 14.9 0.0 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 ORX58204.1 - 0.00014 21.9 0.0 0.0016 18.5 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_5 PF07728.14 ORX58204.1 - 0.00058 19.9 0.0 0.0017 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DNA_pol3_gamma3 PF12169.8 ORX58204.1 - 0.00066 19.6 0.2 0.0035 17.3 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III subunits gamma and tau domain III AAA_30 PF13604.6 ORX58204.1 - 0.00071 19.3 0.0 0.0018 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX58204.1 - 0.00084 19.4 0.0 0.0043 17.1 0.0 2.1 2 1 1 3 3 2 1 AAA domain AAA_assoc_2 PF16193.5 ORX58204.1 - 0.0012 19.1 0.0 0.0054 17.0 0.0 2.1 2 0 0 2 2 1 1 AAA C-terminal domain AAA_19 PF13245.6 ORX58204.1 - 0.0019 18.5 0.0 0.0055 17.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ORX58204.1 - 0.0027 17.5 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ORX58204.1 - 0.0072 15.5 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ORX58204.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 ORX58204.1 - 0.023 14.2 0.0 0.75 9.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 ORX58204.1 - 0.026 13.8 0.0 0.095 11.9 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.6 ORX58204.1 - 0.028 14.7 0.0 0.051 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ORX58204.1 - 0.054 13.4 0.0 0.13 12.1 0.0 1.6 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ORX58204.1 - 0.057 13.9 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ORX58204.1 - 0.062 13.2 0.0 0.3 10.9 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ORX58204.1 - 0.074 12.8 0.5 0.8 9.5 0.0 2.5 2 1 1 3 3 3 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 ORX58204.1 - 0.11 12.9 0.0 0.29 11.6 0.0 1.9 1 1 0 1 1 1 0 RNA helicase ANTH PF07651.16 ORX58205.1 - 4.2e-57 193.2 1.4 2.1e-55 187.7 0.0 4.5 4 1 1 5 5 5 2 ANTH domain I_LWEQ PF01608.17 ORX58205.1 - 1.1e-50 171.8 14.5 1.1e-50 171.8 14.5 6.3 4 2 1 6 6 6 1 I/LWEQ domain FUSC PF04632.12 ORX58205.1 - 8.8e-05 21.2 0.5 8.8e-05 21.2 0.5 3.8 2 2 2 4 4 4 1 Fusaric acid resistance protein family ENTH PF01417.20 ORX58205.1 - 0.0074 16.3 0.6 1.6 8.8 0.0 3.5 2 1 1 3 3 3 2 ENTH domain bZIP_1 PF00170.21 ORX58206.1 - 1.1e-06 28.6 9.6 2.5e-06 27.5 9.6 1.6 1 0 0 1 1 1 1 bZIP transcription factor PHTB1_C PF14728.6 ORX58206.1 - 0.012 14.7 2.5 0.022 13.8 2.5 1.3 1 0 0 1 1 1 0 PTHB1 C-terminus Glutaredoxin2_C PF04399.13 ORX58206.1 - 0.24 11.2 3.5 0.34 10.7 1.2 2.0 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain bZIP_2 PF07716.15 ORX58206.1 - 0.61 10.2 16.8 5.1 7.3 16.8 2.2 1 1 0 1 1 1 0 Basic region leucine zipper Arrestin_C PF02752.22 ORX58207.1 - 9.3e-20 71.4 0.0 1.1e-16 61.5 0.0 2.2 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX58207.1 - 7.1e-13 48.8 0.0 2e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX58207.1 - 4.2e-05 23.3 0.0 9e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Arrestin_N terminal like Rgp1 PF08737.10 ORX58207.1 - 0.011 15.0 0.0 0.094 11.9 0.0 2.0 1 1 0 2 2 2 0 Rgp1 AbiEi_3 PF11459.8 ORX58207.1 - 0.11 12.2 0.1 0.24 11.1 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Ank_4 PF13637.6 ORX58209.1 - 2.4e-13 50.3 0.8 4.6e-06 27.1 0.1 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX58209.1 - 1.1e-12 47.9 0.5 2.6e-08 33.9 0.1 2.6 2 2 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX58209.1 - 1.4e-12 48.0 0.1 2e-12 47.5 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX58209.1 - 1.4e-10 41.1 1.5 2.6e-05 24.4 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ORX58209.1 - 7.3e-10 38.2 0.4 0.00032 20.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat YL1_C PF08265.11 ORX58210.1 - 1.5e-17 63.1 0.4 2.3e-17 62.4 0.4 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain zf-HIT PF04438.16 ORX58210.1 - 0.042 13.7 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 HIT zinc finger AAA PF00004.29 ORX58211.1 - 7.1e-42 143.0 0.0 1.2e-41 142.2 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 ORX58211.1 - 2.3e-12 46.7 0.3 4.7e-12 45.7 0.3 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 ORX58211.1 - 9.6e-10 38.1 0.8 1.8e-09 37.2 0.8 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ORX58211.1 - 4.9e-06 26.8 0.0 1.1e-05 25.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ORX58211.1 - 2.2e-05 23.8 0.0 3.7e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ORX58211.1 - 4.5e-05 23.7 0.2 0.029 14.6 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX58211.1 - 0.00016 22.1 0.1 0.0049 17.3 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX58211.1 - 0.00017 21.6 0.2 0.0012 18.9 0.2 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_OB_N PF17758.1 ORX58211.1 - 0.00047 19.8 0.0 0.0014 18.2 0.0 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain RuvB_N PF05496.12 ORX58211.1 - 0.0006 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 ORX58211.1 - 0.0025 18.4 0.0 0.0061 17.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ORX58211.1 - 0.0049 16.2 0.3 0.24 10.7 0.1 2.8 2 1 1 3 3 3 1 KaiC AAA_3 PF07726.11 ORX58211.1 - 0.0065 16.3 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ORX58211.1 - 0.0069 16.6 0.0 0.016 15.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ORX58211.1 - 0.0077 16.3 0.0 0.021 14.8 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ORX58211.1 - 0.021 15.1 0.5 0.19 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX58211.1 - 0.032 14.0 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 ORX58211.1 - 0.048 12.9 0.0 0.081 12.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain DUF1128 PF06569.11 ORX58211.1 - 0.091 12.8 0.0 0.42 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1128) DUF2075 PF09848.9 ORX58211.1 - 0.1 11.8 0.0 0.15 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ORX58211.1 - 0.11 12.4 0.1 0.78 9.6 0.1 2.2 1 1 1 2 2 2 0 NACHT domain RNA_helicase PF00910.22 ORX58211.1 - 0.12 12.8 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 ORX58211.1 - 0.14 11.9 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 ORX58211.1 - 0.14 11.6 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ORX58211.1 - 0.14 11.3 0.0 0.61 9.2 0.0 2.0 2 0 0 2 2 2 0 NB-ARC domain AAA_25 PF13481.6 ORX58211.1 - 0.28 10.7 0.9 4.8 6.7 0.3 2.7 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX58211.1 - 1.4 8.6 4.2 0.33 10.6 0.3 2.0 2 1 0 2 2 1 0 AAA domain TatD_DNase PF01026.21 ORX58212.1 - 1e-48 166.0 0.0 1.2e-48 165.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase PPR_2 PF13041.6 ORX58213.1 - 6.3e-23 80.7 0.0 0.00013 22.1 0.0 6.9 5 3 2 7 7 7 6 PPR repeat family PPR_3 PF13812.6 ORX58213.1 - 1.4e-10 41.1 0.0 0.029 14.4 0.0 4.8 3 1 0 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX58213.1 - 3.6e-09 36.1 3.8 0.00056 19.6 0.3 5.6 6 0 0 6 6 6 2 PPR repeat PPR PF01535.20 ORX58213.1 - 1.1e-07 31.6 0.6 0.63 10.4 0.0 5.4 6 0 0 6 6 6 2 PPR repeat PPR_long PF17177.4 ORX58213.1 - 0.0033 16.8 2.5 0.094 12.1 0.0 3.6 2 1 3 5 5 5 1 Pentacotripeptide-repeat region of PRORP AAA_25 PF13481.6 ORX58214.1 - 1.5e-21 76.8 0.0 2.5e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain DnaB_C PF03796.15 ORX58214.1 - 4.5e-12 45.9 0.0 8.2e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ORX58214.1 - 4.7e-07 29.4 0.0 6.9e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_22 PF13401.6 ORX58214.1 - 8.6e-07 29.3 0.8 2.8e-06 27.6 0.2 2.1 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 ORX58214.1 - 1.9e-06 28.3 0.1 4.2e-06 27.3 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain ABC_tran PF00005.27 ORX58214.1 - 0.00065 20.2 0.0 0.0014 19.1 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ORX58214.1 - 0.00096 19.7 1.8 0.0015 19.0 0.1 2.1 2 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 ORX58214.1 - 0.0015 18.5 0.1 0.0031 17.5 0.1 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_28 PF13521.6 ORX58214.1 - 0.0018 18.6 0.0 0.0062 16.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ORX58214.1 - 0.0037 16.4 0.0 0.0061 15.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ResIII PF04851.15 ORX58214.1 - 0.0056 16.7 0.0 0.038 14.0 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit ATPase_2 PF01637.18 ORX58214.1 - 0.0065 16.4 0.0 0.015 15.2 0.0 1.5 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea PRK PF00485.18 ORX58214.1 - 0.0068 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family IstB_IS21 PF01695.17 ORX58214.1 - 0.01 15.6 0.0 0.025 14.3 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX58214.1 - 0.012 16.0 0.0 0.023 15.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 ORX58214.1 - 0.016 15.0 0.1 0.05 13.4 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arf PF00025.21 ORX58214.1 - 0.018 14.5 0.2 0.068 12.6 0.0 1.9 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_30 PF13604.6 ORX58214.1 - 0.02 14.6 0.0 0.047 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 ORX58214.1 - 0.021 14.7 0.0 0.037 13.9 0.0 1.5 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_14 PF13173.6 ORX58214.1 - 0.022 14.8 0.2 0.061 13.4 0.2 2.0 1 1 0 1 1 1 0 AAA domain SMC_N PF02463.19 ORX58214.1 - 0.031 13.7 0.1 0.9 8.9 0.0 2.3 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain DUF2075 PF09848.9 ORX58214.1 - 0.032 13.5 0.0 0.064 12.5 0.0 1.5 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ORX58214.1 - 0.034 14.1 0.2 0.12 12.3 0.1 2.0 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ORX58214.1 - 0.037 14.6 0.0 0.098 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX58214.1 - 0.051 13.5 0.0 0.16 11.8 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase PhoH PF02562.16 ORX58214.1 - 0.067 12.6 0.1 0.2 11.1 0.1 2.0 1 1 0 1 1 1 0 PhoH-like protein DUF3438 PF11920.8 ORX58214.1 - 0.07 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) DUF853 PF05872.12 ORX58214.1 - 0.072 11.7 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SRPRB PF09439.10 ORX58214.1 - 0.08 12.4 0.2 1.3 8.4 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ORX58214.1 - 0.093 12.2 0.3 0.27 10.7 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Glyco_hydro_97 PF10566.9 ORX58214.1 - 0.094 12.0 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase 97 AAA PF00004.29 ORX58214.1 - 0.098 13.1 0.3 0.22 11.9 0.1 1.9 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ORX58214.1 - 0.12 12.3 0.2 0.27 11.1 0.2 1.6 1 0 0 1 1 1 0 NTPase AAA_19 PF13245.6 ORX58214.1 - 0.31 11.4 1.3 0.38 11.1 0.1 1.8 2 1 0 2 2 2 0 AAA domain Med14 PF08638.11 ORX58215.1 - 2.5e-52 177.1 2.7 1.3e-40 138.9 0.5 2.5 1 1 1 2 2 2 2 Mediator complex subunit MED14 Tli4_C PF18426.1 ORX58215.1 - 0.04 14.2 0.1 6.2 7.1 0.0 2.7 3 0 0 3 3 3 0 Tle cognate immunity protein 4 C-terminal domain UAA PF08449.11 ORX58216.1 - 8.2e-89 297.8 14.3 1.5e-88 296.9 14.3 1.4 1 1 0 1 1 1 1 UAA transporter family CRT-like PF08627.10 ORX58216.1 - 8.6e-07 28.2 2.6 8.6e-07 28.2 2.6 2.0 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 ORX58216.1 - 2e-05 24.1 6.5 0.0062 15.9 0.4 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family 7TMR-DISM_7TM PF07695.11 ORX58216.1 - 0.00025 21.0 5.0 0.00025 21.0 5.0 2.3 2 2 0 2 2 2 1 7TM diverse intracellular signalling Pox_A14 PF05767.12 ORX58216.1 - 0.0036 17.4 0.1 0.013 15.7 0.1 1.9 1 0 0 1 1 1 1 Poxvirus virion envelope protein A14 EamA PF00892.20 ORX58216.1 - 0.55 10.4 22.6 0.77 9.9 6.9 3.7 2 2 1 3 3 3 0 EamA-like transporter family MSSP PF03940.13 ORX58218.1 - 4.6e-07 29.3 31.3 7.1e-05 22.3 7.9 3.5 1 1 1 2 2 2 2 Male specific sperm protein E1-E2_ATPase PF00122.20 ORX58219.1 - 1.5e-25 89.7 0.0 4.9e-25 88.1 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX58219.1 - 5.8e-09 36.6 0.2 0.055 13.7 0.0 3.7 4 0 0 4 4 4 3 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX58219.1 - 2.9e-05 23.7 0.1 8.7e-05 22.1 0.0 1.8 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Peptidase_M41 PF01434.18 ORX58220.1 - 8e-63 211.7 0.1 1.3e-62 211.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX58220.1 - 2.3e-43 147.8 0.0 1.7e-42 145.0 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX58220.1 - 5.5e-11 42.1 0.0 1.4e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 ORX58220.1 - 1.4e-05 24.9 0.0 0.00012 21.8 0.0 2.2 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX58220.1 - 1.8e-05 25.2 3.4 6.5e-05 23.4 0.4 3.1 2 1 0 2 2 1 1 AAA ATPase domain AAA_5 PF07728.14 ORX58220.1 - 6.7e-05 22.9 0.0 0.00028 20.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX58220.1 - 7.8e-05 23.0 0.5 0.023 15.0 0.0 3.6 3 1 0 4 4 3 1 AAA domain TIP49 PF06068.13 ORX58220.1 - 8.9e-05 21.9 0.0 0.00017 20.9 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 ORX58220.1 - 0.00074 19.1 0.5 0.11 12.1 0.1 2.8 2 1 0 3 3 3 1 AAA domain AAA_14 PF13173.6 ORX58220.1 - 0.0034 17.4 0.0 0.55 10.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ORX58220.1 - 0.0059 16.7 0.0 0.026 14.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ORX58220.1 - 0.011 16.3 0.0 0.053 14.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX58220.1 - 0.012 15.4 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ORX58220.1 - 0.016 14.6 0.2 0.032 13.6 0.2 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ORX58220.1 - 0.027 13.7 0.0 0.061 12.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 ORX58220.1 - 0.03 14.6 0.1 0.14 12.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX58220.1 - 0.031 14.4 0.0 0.082 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ORX58220.1 - 0.068 12.5 0.0 0.42 9.9 0.0 2.2 2 0 0 2 2 2 0 KaiC RNA_helicase PF00910.22 ORX58220.1 - 0.069 13.6 0.0 0.99 9.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 ORX58220.1 - 0.079 12.5 0.1 0.4 10.2 0.1 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ORX58220.1 - 0.12 12.1 0.0 0.34 10.6 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 ORX58220.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 ORX58220.1 - 0.33 11.4 1.4 0.68 10.4 0.0 2.2 3 0 0 3 3 2 0 AAA domain ABC_membrane PF00664.23 ORX58221.1 - 6.3e-38 131.0 7.9 8.9e-38 130.5 7.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX58221.1 - 1.2e-37 129.5 0.0 2.1e-37 128.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX58221.1 - 4.2e-06 26.4 0.1 0.00011 21.7 0.0 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX58221.1 - 4e-05 24.1 0.0 0.0001 22.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 ORX58221.1 - 0.0018 18.4 0.1 0.0048 17.1 0.0 1.8 2 0 0 2 2 1 1 AAA domain RsgA_GTPase PF03193.16 ORX58221.1 - 0.0019 18.1 0.0 0.0062 16.5 0.0 1.9 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ORX58221.1 - 0.0021 18.3 0.1 0.016 15.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ORX58221.1 - 0.0039 17.6 0.1 0.039 14.4 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX58221.1 - 0.012 15.7 0.0 0.031 14.4 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ORX58221.1 - 0.021 14.4 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ORX58221.1 - 0.036 13.8 0.1 0.089 12.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1358 PF07096.11 ORX58221.1 - 0.059 13.4 0.0 0.29 11.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1358) AAA_30 PF13604.6 ORX58221.1 - 0.082 12.6 0.0 0.38 10.4 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ORX58221.1 - 0.095 12.7 0.0 0.46 10.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ORX58221.1 - 0.11 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_15 PF13175.6 ORX58221.1 - 0.14 11.9 0.1 0.28 10.9 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain Corona_M PF01635.18 ORX58221.1 - 0.15 11.4 1.4 3.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Coronavirus M matrix/glycoprotein AAA_14 PF13173.6 ORX58221.1 - 0.15 12.1 0.0 0.89 9.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain MFS_1 PF07690.16 ORX58222.1 - 2.8e-23 82.4 40.6 2.2e-19 69.6 26.0 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 ORX58222.1 - 0.0015 16.9 2.4 0.0037 15.6 2.4 1.7 1 1 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Lactonase PF10282.9 ORX58224.1 - 1.5e-08 34.3 0.0 2.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller WD40 PF00400.32 ORX58224.1 - 6e-05 23.7 4.4 0.95 10.4 0.1 4.7 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58224.1 - 0.00016 21.9 0.0 0.9 9.9 0.0 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX58224.1 - 0.00056 18.5 0.0 0.00093 17.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain ACT_7 PF13840.6 ORX58225.1 - 9.1e-22 76.6 0.0 1.3e-21 76.2 0.0 1.2 1 0 0 1 1 1 1 ACT domain PhaG_MnhG_YufB PF03334.14 ORX58226.1 - 2.4 8.5 17.8 8.4 6.7 3.8 3.9 3 2 0 3 3 3 0 Na+/H+ antiporter subunit Kinesin PF00225.23 ORX58227.1 - 1.3e-94 316.9 0.2 1.9e-94 316.4 0.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX58227.1 - 1.9e-18 66.8 0.3 5.6e-18 65.3 0.0 1.9 2 0 0 2 2 2 1 Microtubule binding SAM_1 PF00536.30 ORX58227.1 - 1.7e-08 34.8 0.1 3.8e-08 33.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ORX58227.1 - 3e-07 30.5 0.2 6e-07 29.5 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4680 PF15730.5 ORX58227.1 - 2.3 8.6 5.1 0.34 11.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4680) DNA_primase_S PF01896.19 ORX58229.1 - 1.8e-57 194.3 0.3 2.6e-57 193.7 0.3 1.3 1 0 0 1 1 1 1 DNA primase small subunit Glyco_hydro_11 PF00457.17 ORX58229.1 - 0.12 12.0 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 11 YjcZ PF13990.6 ORX58231.1 - 0.014 14.7 0.1 0.016 14.6 0.1 1.1 1 0 0 1 1 1 0 YjcZ-like protein RWD PF05773.22 ORX58231.1 - 0.043 14.1 0.1 1.8 8.9 0.1 2.3 1 1 0 1 1 1 0 RWD domain Spot_14 PF07084.12 ORX58231.1 - 0.099 12.8 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 tRNA-synt_1d PF00750.19 ORX58232.1 - 4.5e-87 292.2 0.0 5.7e-87 291.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ORX58232.1 - 4.3e-25 88.2 0.0 9.6e-25 87.1 0.0 1.6 1 0 0 1 1 1 1 DALR anticodon binding domain Mur_ligase_M PF08245.12 ORX58233.1 - 1e-10 41.9 0.0 2.8e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Mur ligase middle domain SurA_N_2 PF13623.6 ORX58233.1 - 0.045 13.6 0.0 0.074 12.9 0.0 1.2 1 0 0 1 1 1 0 SurA N-terminal domain ATG16 PF08614.11 ORX58234.1 - 0.00016 22.0 0.9 0.00016 22.0 0.9 2.2 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ORX58234.1 - 0.033 14.6 1.5 0.033 14.6 1.5 2.1 2 0 0 2 2 2 0 Fez1 Mga PF05043.13 ORX58234.1 - 1.8 9.2 8.0 0.89 10.2 1.2 2.7 2 1 0 2 2 2 0 Mga helix-turn-helix domain Fmp27_WPPW PF10359.9 ORX58234.1 - 2.8 6.7 16.6 0.81 8.5 1.5 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain SpoIIE PF07228.12 ORX58235.1 - 2.2e-12 47.3 0.1 3.1e-12 46.8 0.1 1.2 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ORX58235.1 - 2.8e-09 36.9 0.5 1.3e-08 34.8 0.5 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 ORX58235.1 - 1.2e-08 35.0 0.1 0.0025 17.5 0.1 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C Yae1_N PF09811.9 ORX58236.1 - 1.7e-12 46.8 8.8 3e-12 46.0 8.8 1.4 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Pkinase PF00069.25 ORX58238.1 - 7.7e-50 169.7 0.0 1.1e-49 169.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58238.1 - 2.6e-34 118.7 0.0 3.3e-34 118.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX58238.1 - 0.00015 21.2 0.0 0.00027 20.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX58238.1 - 0.00018 20.4 0.0 0.0003 19.7 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ORX58238.1 - 0.096 12.3 0.0 6.5 6.3 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 zf-C2H2 PF00096.26 ORX58239.1 - 4.6e-08 33.1 9.9 0.0016 18.8 3.8 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX58239.1 - 1.6e-06 28.4 6.6 0.014 16.1 2.2 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX58239.1 - 0.015 15.1 6.8 0.073 12.8 2.2 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX58239.1 - 0.016 15.2 3.5 0.054 13.5 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf_ZIC PF18366.1 ORX58239.1 - 0.047 13.8 0.5 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-H2C2_2 PF13465.6 ORX58239.1 - 0.055 13.9 5.0 0.055 13.9 5.0 2.9 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2HE PF16278.5 ORX58239.1 - 0.15 12.5 1.5 0.4 11.2 1.5 1.7 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger CLP_protease PF00574.23 ORX58240.1 - 2.1e-82 275.4 0.0 2.5e-82 275.2 0.0 1.0 1 0 0 1 1 1 1 Clp protease SDH_sah PF01972.16 ORX58240.1 - 0.12 11.4 0.0 0.2 10.6 0.0 1.3 1 0 0 1 1 1 0 Serine dehydrogenase proteinase zf-Paramyx-P PF13008.7 ORX58241.1 - 0.28 10.7 3.6 13 5.3 1.6 2.3 2 0 0 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein E1-E2_ATPase PF00122.20 ORX58242.1 - 1.7e-20 73.3 0.0 3.5e-20 72.3 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ORX58242.1 - 7.4e-18 65.6 0.0 5e-11 43.3 0.1 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX58242.1 - 2.1e-05 24.5 0.0 4.8e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX58242.1 - 0.027 14.2 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SET PF00856.28 ORX58244.1 - 1e-05 26.0 0.0 0.00011 22.7 0.0 2.3 1 1 0 1 1 1 1 SET domain zf-MYND PF01753.18 ORX58244.1 - 0.00027 21.0 15.7 0.00027 21.0 15.7 2.0 2 0 0 2 2 2 1 MYND finger SAF PF08666.12 ORX58244.1 - 0.013 16.1 0.0 6.1 7.6 0.0 2.5 2 0 0 2 2 2 0 SAF domain DUF3857 PF12969.7 ORX58244.1 - 0.066 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3857) zf-C6H2 PF15801.5 ORX58244.1 - 1.8 8.9 12.6 4.4 7.7 12.6 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding DUF4448 PF14610.6 ORX58245.1 - 2.4e-09 37.2 1.0 5.2e-09 36.1 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Stevor PF17410.2 ORX58245.1 - 0.17 11.4 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Collectrin PF16959.5 ORX58246.1 - 0.11 12.2 0.0 3.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Renal amino acid transporter DUF2754 PF10953.8 ORX58246.1 - 9.8 6.5 10.5 0.26 11.6 2.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2754) bZIP_2 PF07716.15 ORX58247.1 - 6.9e-12 45.3 7.0 7.4e-12 45.2 2.6 2.2 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX58247.1 - 3e-08 33.6 8.5 4e-08 33.2 6.4 2.0 1 1 1 2 2 2 1 bZIP transcription factor ADIP PF11559.8 ORX58247.1 - 0.0051 16.9 3.1 0.0081 16.2 3.1 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF4472 PF14739.6 ORX58247.1 - 0.014 16.1 2.1 0.023 15.4 1.6 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4472) bZIP_Maf PF03131.17 ORX58247.1 - 0.029 14.9 4.0 0.031 14.8 1.3 2.0 1 1 1 2 2 2 0 bZIP Maf transcription factor HalX PF08663.10 ORX58247.1 - 0.052 13.9 3.3 0.12 12.7 3.3 1.6 1 0 0 1 1 1 0 HalX domain Spc7 PF08317.11 ORX58247.1 - 0.059 12.2 2.3 0.078 11.8 2.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein PKcGMP_CC PF16808.5 ORX58247.1 - 0.1 12.5 0.2 0.24 11.3 0.2 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran_CTD PF16326.5 ORX58247.1 - 0.25 11.6 5.0 4.5 7.6 1.1 2.5 1 1 1 2 2 2 0 ABC transporter C-terminal domain XhlA PF10779.9 ORX58247.1 - 0.26 11.5 0.6 0.46 10.7 0.6 1.4 1 0 0 1 1 1 0 Haemolysin XhlA AAA_13 PF13166.6 ORX58247.1 - 0.32 9.6 2.4 0.41 9.2 2.4 1.1 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 ORX58247.1 - 0.32 10.8 1.4 0.57 10.0 1.4 1.4 1 0 0 1 1 1 0 Septum formation initiator Nup54 PF13874.6 ORX58247.1 - 0.34 11.0 4.3 0.56 10.3 4.3 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Striatin PF08232.12 ORX58247.1 - 0.43 11.2 3.5 0.19 12.3 1.0 1.6 2 0 0 2 2 2 0 Striatin family DUF724 PF05266.14 ORX58247.1 - 0.52 10.1 3.9 0.79 9.5 3.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4140 PF13600.6 ORX58247.1 - 1 9.9 5.1 6.9 7.2 0.9 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 ORX58247.1 - 5.1 7.6 8.6 1.7 9.1 2.9 2.1 1 1 1 2 2 2 0 Cell division protein ZapB Methyltransf_25 PF13649.6 ORX58248.1 - 3.2e-14 53.4 0.0 7.9e-14 52.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX58248.1 - 4.8e-11 43.2 0.0 1.1e-10 42.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX58248.1 - 1.4e-10 41.2 0.0 2.5e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX58248.1 - 1.4e-08 34.7 0.0 1.5e-07 31.3 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX58248.1 - 5.7e-06 25.8 0.0 9.7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX58248.1 - 2e-05 25.2 0.0 5.9e-05 23.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX58248.1 - 0.0013 18.2 0.0 0.005 16.3 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase MTS PF05175.14 ORX58248.1 - 0.0014 18.2 0.0 0.0064 16.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ORX58248.1 - 0.0044 16.9 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 Hypothetical methyltransferase CheR PF01739.18 ORX58248.1 - 0.079 12.4 0.0 0.65 9.4 0.0 2.3 3 0 0 3 3 3 0 CheR methyltransferase, SAM binding domain Methyltransf_29 PF03141.16 ORX58248.1 - 0.13 10.8 1.0 0.51 8.8 0.0 2.2 3 0 0 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Abhydrolase_1 PF00561.20 ORX58249.1 - 4.2e-12 46.3 0.2 4e-08 33.2 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX58249.1 - 1.6e-09 37.4 0.1 8.8e-07 28.4 0.0 2.5 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX58249.1 - 3.6e-09 37.6 1.2 3.6e-09 37.6 1.2 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ORX58249.1 - 5.8e-06 26.1 0.0 0.016 14.8 0.0 2.3 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 ORX58249.1 - 1.1e-05 25.4 0.0 2.5e-05 24.3 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Thioesterase PF00975.20 ORX58249.1 - 9.7e-05 22.6 0.0 0.00015 21.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain Peptidase_S9 PF00326.21 ORX58249.1 - 0.0003 20.3 0.0 0.00053 19.5 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ORX58249.1 - 0.0014 18.2 0.0 0.82 9.2 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 ORX58249.1 - 0.014 15.3 0.0 3.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Chlorophyllase2 PF12740.7 ORX58249.1 - 0.039 12.9 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Lipase PF00151.19 ORX58249.1 - 0.044 13.1 0.0 0.061 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipase BAAT_C PF08840.11 ORX58249.1 - 0.047 13.6 0.0 0.38 10.7 0.0 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 ORX58249.1 - 0.18 11.7 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) HSP70 PF00012.20 ORX58250.1 - 6.8e-09 34.5 0.0 3.8e-07 28.7 0.0 2.3 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ORX58250.1 - 0.062 12.1 0.0 0.14 11.0 0.0 1.5 2 0 0 2 2 2 0 MreB/Mbl protein Cecropin PF00272.19 ORX58250.1 - 0.11 12.3 0.7 0.2 11.4 0.7 1.4 1 0 0 1 1 1 0 Cecropin family G-patch PF01585.23 ORX58251.1 - 3.2e-11 42.9 1.9 5.5e-11 42.2 1.9 1.4 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 ORX58251.1 - 0.0077 16.0 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chorion_S16 PF05836.12 ORX58251.1 - 0.069 13.4 0.2 0.14 12.4 0.2 1.4 1 0 0 1 1 1 0 Chorion protein S16 G-patch_2 PF12656.7 ORX58251.1 - 0.073 13.2 0.5 0.21 11.7 0.5 1.8 1 0 0 1 1 1 0 G-patch domain S4 PF01479.25 ORX58254.1 - 2.2e-12 46.5 1.4 2.2e-12 46.5 1.4 2.1 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 ORX58254.1 - 0.0001 23.1 0.1 0.00024 22.0 0.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 ORX58255.1 - 2e-45 152.8 4.4 2e-45 152.8 4.4 1.4 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 ORX58255.1 - 0.045 13.3 0.0 0.056 13.0 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 WD40 PF00400.32 ORX58256.1 - 4.4e-43 144.4 19.7 1.9e-07 31.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58256.1 - 2.5e-13 50.1 0.0 6e-05 23.3 0.1 4.9 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX58256.1 - 2.5e-05 23.8 0.0 0.7 9.2 0.0 3.8 2 1 1 4 4 4 2 WD40-like domain eIF2A PF08662.11 ORX58256.1 - 2.6e-05 24.2 0.0 0.012 15.5 0.0 2.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX58256.1 - 0.001 18.1 1.2 1.1 8.1 0.0 4.1 3 2 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ORX58256.1 - 0.011 14.3 0.0 0.63 8.5 0.0 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain TAF PF02969.17 ORX58256.1 - 0.041 14.0 0.7 0.097 12.9 0.7 1.6 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) VID27 PF08553.10 ORX58256.1 - 0.069 12.2 0.0 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Mgm101p PF06420.12 ORX58257.1 - 2.3e-88 294.1 0.0 2.9e-88 293.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Gal_mutarotas_2 PF13802.6 ORX58258.1 - 3.4e-15 56.1 0.1 8.7e-15 54.8 0.1 1.7 2 0 0 2 2 2 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 ORX58260.1 - 2.2e-09 37.0 0.1 2.3e-09 37.0 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 zf-DNL PF05180.12 ORX58261.1 - 3e-32 110.4 0.4 3.3e-32 110.2 0.4 1.0 1 0 0 1 1 1 1 DNL zinc finger TF_Zn_Ribbon PF08271.12 ORX58261.1 - 0.02 14.4 2.0 0.17 11.5 0.1 2.2 2 1 0 2 2 2 0 TFIIB zinc-binding UPF0167 PF03691.14 ORX58261.1 - 0.024 14.4 0.2 0.027 14.2 0.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) zinc_ribbon_4 PF13717.6 ORX58261.1 - 0.059 13.3 2.0 0.11 12.5 0.1 2.1 2 1 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.18 ORX58261.1 - 0.1 12.5 2.5 2 8.3 0.2 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) PADR1 PF08063.12 ORX58261.1 - 0.12 12.1 1.6 0.35 10.7 0.1 2.0 1 1 1 2 2 2 0 PADR1 (NUC008) domain Zn_Tnp_IS1595 PF12760.7 ORX58261.1 - 0.18 11.8 3.5 3.8 7.6 0.3 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 ORX58261.1 - 2.1 9.0 5.7 4.2 8.0 0.6 2.4 1 1 1 2 2 2 0 Zinc-finger double domain IFRD PF05004.13 ORX58262.1 - 4.9e-24 85.0 8.9 7e-24 84.5 8.6 1.4 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) SbcD_C PF12320.8 ORX58262.1 - 1.1 9.6 5.9 3.1 8.2 0.3 2.9 2 1 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain HLH PF00010.26 ORX58263.1 - 1.2e-17 63.6 0.9 2.6e-17 62.5 0.9 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain RCC1 PF00415.18 ORX58264.1 - 2.2e-54 181.9 5.1 3.4e-12 46.8 0.1 6.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX58264.1 - 4.3e-25 86.9 25.3 1.9e-06 27.5 0.8 7.5 7 1 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat PHD PF00628.29 ORX58264.1 - 7.7e-12 44.9 8.1 1.3e-11 44.2 8.1 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX58264.1 - 0.00017 21.1 1.9 0.00017 21.1 1.9 2.1 2 0 0 2 2 2 1 PHD-finger zf-RRN7 PF11781.8 ORX58264.1 - 0.044 13.5 1.0 0.15 11.7 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF4213 PF13938.6 ORX58264.1 - 0.073 13.3 0.5 2.7 8.3 0.0 3.2 4 0 0 4 4 4 0 Putative heavy-metal chelation C1_2 PF03107.16 ORX58264.1 - 0.17 12.3 2.7 0.18 12.2 0.6 2.2 2 0 0 2 2 2 0 C1 domain Rep_fac-A_C PF08646.10 ORX58264.1 - 1.7 8.4 7.4 10 5.9 0.2 2.3 1 1 1 2 2 2 0 Replication factor-A C terminal domain WD40 PF00400.32 ORX58265.1 - 1.3e-23 82.8 18.3 5.9e-07 30.1 0.4 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat DUF3337 PF11816.8 ORX58265.1 - 2.7e-18 66.4 0.0 5.1e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) ANAPC4_WD40 PF12894.7 ORX58265.1 - 1.1e-05 25.6 0.4 0.026 14.8 0.1 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX58265.1 - 4.4e-05 23.0 0.0 0.0056 16.0 0.0 2.5 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ORX58265.1 - 0.00097 18.2 0.2 0.013 14.5 0.0 2.1 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ORX58265.1 - 0.26 9.9 2.3 1.6 7.3 0.2 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF3337 PF11816.8 ORX58266.1 - 3.4e-11 43.3 0.0 3.8e-11 43.2 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3337) zf-C2H2_12 PF18658.1 ORX58266.1 - 0.011 15.3 0.0 0.011 15.3 0.0 1.1 1 0 0 1 1 1 0 Zinc-finger C2H2-type RhoGEF PF00621.20 ORX58267.1 - 6e-18 65.7 0.5 1.1e-17 64.9 0.5 1.5 1 0 0 1 1 1 1 RhoGEF domain PH PF00169.29 ORX58267.1 - 9.9e-05 22.8 0.0 0.00023 21.6 0.0 1.6 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ORX58267.1 - 0.00013 21.8 0.2 0.0012 18.7 0.0 2.5 2 2 0 2 2 2 1 Pleckstrin homology domain GPI-anchored PF10342.9 ORX58268.1 - 1.7e-07 31.9 1.4 8.5e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Miga PF10265.9 ORX58268.1 - 1 8.3 4.6 1.2 8.0 4.6 1.1 1 0 0 1 1 1 0 Mitoguardin Macoilin PF09726.9 ORX58268.1 - 9.1 4.7 7.1 12 4.3 7.1 1.1 1 0 0 1 1 1 0 Macoilin family TIP49 PF06068.13 ORX58271.1 - 6.7e-161 535.3 2.0 9.3e-161 534.9 2.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 ORX58271.1 - 4.6e-29 100.4 0.9 2.4e-28 98.1 1.2 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain RuvB_N PF05496.12 ORX58271.1 - 5.6e-08 32.7 2.1 0.0022 17.8 0.0 3.4 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ORX58271.1 - 5.8e-08 33.2 4.4 0.0003 21.2 0.1 3.6 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 ORX58271.1 - 2.4e-06 27.1 0.4 4.9e-06 26.1 0.4 1.4 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_5 PF07728.14 ORX58271.1 - 0.00074 19.5 0.4 1.2 9.1 0.1 3.0 2 1 1 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX58271.1 - 0.00087 19.6 0.3 0.073 13.3 0.0 2.7 1 1 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ORX58271.1 - 0.0011 18.4 0.9 0.1 12.0 0.4 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ORX58271.1 - 0.0017 18.8 0.1 0.0068 16.8 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 ORX58271.1 - 0.0089 15.7 0.7 6 6.6 0.0 3.4 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_19 PF13245.6 ORX58271.1 - 0.016 15.6 6.2 0.017 15.5 2.3 2.8 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ORX58271.1 - 0.036 13.6 1.4 0.054 13.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ORX58271.1 - 0.14 11.3 0.0 0.24 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 PWWP PF00855.17 ORX58273.1 - 1.9e-20 73.1 0.3 1.9e-20 73.1 0.3 2.2 2 1 0 2 2 2 1 PWWP domain Med26 PF08711.11 ORX58273.1 - 0.00013 21.9 0.0 0.00049 20.1 0.0 2.0 1 0 0 1 1 1 1 TFIIS helical bundle-like domain CDC45 PF02724.14 ORX58273.1 - 0.042 12.2 16.6 0.061 11.6 16.6 1.2 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ORX58273.1 - 0.32 9.0 7.7 0.4 8.7 7.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen YL1 PF05764.13 ORX58273.1 - 0.38 10.8 21.4 0.6 10.2 21.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein PQ-loop PF04193.14 ORX58275.1 - 2.1e-25 88.3 7.8 2.1e-12 46.6 0.8 3.0 3 1 0 3 3 3 2 PQ loop repeat ASFV_L11L PF05293.11 ORX58275.1 - 0.21 11.9 2.7 2.1 8.8 0.2 2.5 1 1 1 2 2 2 0 African swine fever virus (ASFV) L11L protein HA2 PF04408.23 ORX58277.1 - 2.7e-19 69.4 0.0 4.8e-19 68.6 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ORX58277.1 - 2.3e-17 63.1 0.0 6e-17 61.8 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ORX58277.1 - 3.5e-14 53.1 0.0 7.6e-14 52.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ribosomal_L14 PF00238.19 ORX58278.1 - 2e-36 124.7 0.1 2.4e-36 124.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DUF4164 PF13747.6 ORX58279.1 - 0.028 14.7 3.4 0.028 14.7 3.4 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF4164) Nbl1_Borealin_N PF10444.9 ORX58279.1 - 0.031 13.9 2.7 0.04 13.6 0.1 2.6 3 0 0 3 3 3 0 Nbl1 / Borealin N terminal OLF PF02191.16 ORX58279.1 - 0.037 13.5 0.5 0.11 12.0 0.0 1.9 2 1 1 3 3 3 0 Olfactomedin-like domain Glu-tRNAGln PF02686.15 ORX58279.1 - 0.038 14.3 1.1 0.12 12.7 1.1 1.9 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit Hemerythrin PF01814.23 ORX58279.1 - 0.083 13.5 2.7 0.21 12.2 1.1 2.4 1 1 1 2 2 2 0 Hemerythrin HHE cation binding domain AAA_13 PF13166.6 ORX58279.1 - 0.087 11.5 12.9 0.12 11.0 12.9 1.1 1 0 0 1 1 1 0 AAA domain ArAE_2_N PF10337.9 ORX58279.1 - 0.13 11.3 3.7 0.18 10.8 3.7 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Spc7 PF08317.11 ORX58279.1 - 0.48 9.3 19.5 1.9 7.3 18.7 2.0 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3153 PF11353.8 ORX58279.1 - 0.54 9.8 4.1 0.85 9.2 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3153) DUF4201 PF13870.6 ORX58279.1 - 0.58 9.9 17.5 1.2 8.9 17.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF4200 PF13863.6 ORX58279.1 - 0.6 10.5 25.6 0.083 13.3 7.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Spore_III_AB PF09548.10 ORX58279.1 - 0.73 9.9 9.3 1.4 9.0 9.3 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) ECH_2 PF16113.5 ORX58279.1 - 1.1 8.7 6.5 0.56 9.7 2.1 2.0 1 1 1 2 2 2 0 Enoyl-CoA hydratase/isomerase HrpB7 PF09486.10 ORX58279.1 - 1.1 9.6 10.8 0.17 12.3 3.3 2.7 2 1 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) NPV_P10 PF05531.12 ORX58279.1 - 1.3 9.5 8.4 9 6.8 0.8 3.7 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Rx_N PF18052.1 ORX58279.1 - 1.4 9.2 11.7 1.1 9.6 2.1 3.4 2 1 2 4 4 4 0 Rx N-terminal domain Laminin_II PF06009.12 ORX58279.1 - 1.6 8.8 9.1 4.7 7.2 3.6 2.6 1 1 1 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 ORX58279.1 - 4 6.9 13.6 8.9 5.8 13.7 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Cnn_1N PF07989.11 ORX58279.1 - 4.5 7.5 15.5 0.18 12.0 5.5 3.2 2 1 2 4 4 3 0 Centrosomin N-terminal motif 1 DUF5320 PF17253.2 ORX58279.1 - 4.7 8.3 6.1 16 6.6 0.0 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5320) APG6_N PF17675.1 ORX58279.1 - 5.8 7.5 22.6 2.9e+03 -1.3 20.6 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Baculo_PEP_C PF04513.12 ORX58279.1 - 9.9 6.2 10.0 8.4 6.4 2.2 3.1 3 1 1 4 4 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Ras PF00071.22 ORX58280.1 - 3e-61 205.8 0.2 3.5e-61 205.6 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX58280.1 - 3.7e-34 117.5 0.1 8.5e-34 116.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX58280.1 - 2.5e-13 49.9 0.0 2.8e-13 49.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX58280.1 - 1.1e-05 25.5 0.0 1.8e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX58280.1 - 0.00018 21.5 0.1 0.097 12.6 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX58280.1 - 0.00046 19.8 0.1 0.0023 17.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX58280.1 - 0.0063 15.9 0.0 0.0088 15.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ORX58280.1 - 0.0094 15.7 0.1 0.015 15.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain FeoB_N PF02421.18 ORX58280.1 - 0.019 14.5 0.0 0.34 10.4 0.0 2.0 2 0 0 2 2 2 0 Ferrous iron transport protein B DAP3 PF10236.9 ORX58280.1 - 0.04 13.1 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 ORX58280.1 - 0.069 13.4 0.1 0.24 11.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX58280.1 - 0.14 12.7 0.3 0.24 11.9 0.3 1.8 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ORX58280.1 - 0.14 11.9 0.0 0.34 10.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DEAD PF00270.29 ORX58281.1 - 4.5e-45 153.6 0.2 8.7e-45 152.6 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX58281.1 - 3.4e-33 114.3 0.1 1.6e-32 112.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX58281.1 - 0.00055 20.0 0.0 0.0011 19.0 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ORX58281.1 - 0.0022 17.7 0.0 0.0037 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX58281.1 - 0.0038 17.6 0.8 0.022 15.1 0.5 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX58281.1 - 0.0091 16.3 0.4 0.042 14.1 0.4 2.0 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ORX58281.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 Helicase NDUFA12 PF05071.16 ORX58282.1 - 2.2e-27 95.7 0.5 2.7e-27 95.5 0.5 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 TMEM237 PF15383.6 ORX58283.1 - 0.004 16.3 1.8 0.008 15.3 1.8 1.4 1 0 0 1 1 1 1 Transmembrane protein 237 DUF3481 PF11980.8 ORX58283.1 - 0.18 11.5 1.5 0.59 9.9 1.5 1.8 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Plus-3 PF03126.18 ORX58284.1 - 8.5e-30 103.5 0.9 3.3e-29 101.6 0.0 2.3 2 0 0 2 2 2 1 Plus-3 domain AtuA PF07287.11 ORX58285.1 - 5.4e-111 370.7 0.0 7.1e-111 370.3 0.0 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA DUF5051 PF16473.5 ORX58286.1 - 0.057 13.4 0.2 0.099 12.6 0.2 1.3 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Ribosomal_S16 PF00886.19 ORX58288.1 - 1e-27 96.0 0.2 1.3e-27 95.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S16 tRNA-synt_2b PF00587.25 ORX58289.1 - 2e-38 132.1 0.0 4.1e-38 131.1 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX58289.1 - 4.2e-13 49.2 0.0 1.3e-11 44.5 0.0 2.9 3 0 0 3 3 3 1 Anticodon binding domain PriA_CRR PF18319.1 ORX58289.1 - 1.2 9.2 15.1 0.057 13.4 1.1 3.5 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain Tom7 PF08038.12 ORX58290.1 - 6.7e-16 57.7 0.4 7.5e-16 57.5 0.4 1.0 1 0 0 1 1 1 1 TOM7 family PI3_PI4_kinase PF00454.27 ORX58291.1 - 5.5e-30 105.0 0.3 1.6e-27 96.9 0.1 3.1 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 ORX58291.1 - 1e-06 28.6 0.0 2.4e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 ORX58291.1 - 0.00032 20.2 0.1 0.00072 19.0 0.1 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ORX58291.1 - 0.051 12.9 0.0 0.097 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) AIP3 PF03915.13 ORX58292.1 - 1e-114 383.8 13.4 1.9e-114 382.9 13.4 1.4 1 0 0 1 1 1 1 Actin interacting protein 3 CAP_N PF01213.19 ORX58292.1 - 0.0029 17.2 21.7 0.017 14.6 1.4 4.2 3 0 0 3 3 3 2 Adenylate cyclase associated (CAP) N terminal FAM219A PF15260.6 ORX58292.1 - 0.059 13.7 6.2 12 6.3 1.2 3.7 3 0 0 3 3 3 0 Protein family FAM219A Lzipper-MIP1 PF14389.6 ORX58292.1 - 0.17 12.2 7.6 0.9 9.9 1.8 3.9 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 LURAP PF14854.6 ORX58292.1 - 0.6 10.1 8.0 0.25 11.3 2.2 2.7 2 0 0 2 2 2 0 Leucine rich adaptor protein DUF1539 PF07560.11 ORX58292.1 - 0.76 9.9 5.4 4 7.5 0.0 3.7 4 0 0 4 4 4 0 Domain of Unknown Function (DUF1539) DUF4600 PF15372.6 ORX58292.1 - 1.4 9.4 15.8 0.05 14.1 2.2 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4600) DUF1640 PF07798.11 ORX58292.1 - 2.6 8.1 12.7 0.13 12.3 5.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1640) LSM PF01423.22 ORX58293.1 - 3.2e-18 65.2 1.6 4.2e-18 64.8 1.6 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX58293.1 - 0.034 14.3 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 Ataxin 2 SM domain Gemin7 PF11095.8 ORX58293.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Gem-associated protein 7 (Gemin7) Ribosomal_L36e PF01158.18 ORX58294.1 - 0.00013 22.2 0.2 0.0002 21.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L36e Ribosomal_L36e PF01158.18 ORX58295.1 - 1.2e-30 105.6 3.5 1.4e-30 105.4 3.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e Vta1 PF04652.16 ORX58296.1 - 4.9e-48 162.8 0.1 8e-48 162.1 0.1 1.3 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 ORX58296.1 - 1.6e-14 53.3 0.8 1.6e-14 53.3 0.8 2.0 2 0 0 2 2 2 1 Vta1 C-terminal domain PCI PF01399.27 ORX58297.1 - 2.9e-23 82.4 2.4 1.5e-22 80.0 0.3 2.8 2 0 0 2 2 2 1 PCI domain GCP_N_terminal PF17681.1 ORX58297.1 - 0.00068 19.4 1.1 0.017 14.7 1.0 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal DUF1090 PF06476.12 ORX58297.1 - 0.093 12.8 2.7 3.3 7.9 1.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1090) DDRGK PF09756.9 ORX58297.1 - 7.1 6.2 13.1 0.85 9.2 0.4 2.9 3 0 0 3 3 3 0 DDRGK domain Raptor_N PF14538.6 ORX58298.1 - 3.3e-66 221.8 0.0 6.8e-66 220.7 0.0 1.6 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 ORX58298.1 - 3.5e-14 53.0 7.6 0.071 14.0 0.2 7.6 7 0 0 7 7 7 3 WD domain, G-beta repeat HEAT PF02985.22 ORX58298.1 - 9.9e-07 28.5 7.5 0.017 15.3 0.0 5.6 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 ORX58298.1 - 2.2e-05 24.7 0.4 0.0003 21.1 0.1 2.8 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 ORX58298.1 - 0.00011 22.3 0.0 0.0026 17.8 0.0 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 BBS2_Mid PF14783.6 ORX58298.1 - 0.0017 18.3 0.2 0.1 12.7 0.0 3.1 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ORX58298.1 - 0.0026 18.0 0.8 13 6.2 0.1 4.8 2 1 4 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain MFS_1_like PF12832.7 ORX58299.1 - 4.8e-11 42.2 1.9 5.4e-11 42.0 1.9 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ORX58299.1 - 3.6e-08 32.7 7.1 3.6e-08 32.7 7.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Nuc_H_symport PF03825.16 ORX58299.1 - 3.8e-08 32.7 3.5 4.1e-08 32.6 3.5 1.0 1 0 0 1 1 1 1 Nucleoside H+ symporter Nodulin-like PF06813.13 ORX58299.1 - 0.029 13.9 3.4 0.038 13.5 3.4 1.1 1 0 0 1 1 1 0 Nodulin-like zf-C2H2 PF00096.26 ORX58300.1 - 1.8e-09 37.5 13.1 5.5e-05 23.4 1.7 2.7 3 0 0 3 3 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX58300.1 - 1.8e-08 34.4 17.7 4.1e-05 23.8 0.8 3.6 4 0 0 4 4 3 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX58300.1 - 1e-06 28.6 2.6 0.00045 20.1 0.9 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX58300.1 - 1.8e-06 28.3 11.6 0.0013 19.4 1.2 2.7 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX58300.1 - 5.6e-05 23.3 0.3 0.00019 21.6 0.3 1.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX58300.1 - 0.00019 21.7 0.2 0.00056 20.2 0.2 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-DNA_Pol PF08996.10 ORX58300.1 - 0.0052 16.6 0.3 0.0062 16.3 0.3 1.2 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger Zn-ribbon_8 PF09723.10 ORX58300.1 - 0.018 15.2 2.1 0.38 10.9 2.8 2.2 1 1 1 2 2 2 0 Zinc ribbon domain Zn_ribbon_SprT PF17283.2 ORX58300.1 - 0.021 14.7 1.0 0.021 14.7 1.0 2.8 3 0 0 3 3 3 0 SprT-like zinc ribbon domain zf_UBZ PF18439.1 ORX58300.1 - 0.052 13.2 0.4 0.12 12.0 0.2 1.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 ORX58300.1 - 0.062 13.1 1.1 0.062 13.1 1.1 3.0 3 0 0 3 3 3 0 zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 ORX58300.1 - 0.16 11.9 3.9 0.35 10.9 3.9 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-Di19 PF05605.12 ORX58300.1 - 0.25 11.7 3.4 0.61 10.4 3.4 1.7 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 ORX58300.1 - 2.5 8.1 9.4 2.7 8.0 0.1 2.6 3 0 0 3 3 2 0 zinc-finger of a C2HC-type F-box-like PF12937.7 ORX58301.1 - 4.4e-06 26.5 0.7 9.4e-06 25.4 0.7 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX58301.1 - 0.00047 20.0 0.7 0.0013 18.6 0.7 1.7 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ORX58301.1 - 0.0063 16.4 0.7 0.024 14.5 0.1 2.0 1 1 1 2 2 2 1 F-box WD40 PF00400.32 ORX58302.1 - 4.1e-17 62.2 10.8 0.00036 21.3 0.2 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58302.1 - 5.5e-09 36.2 0.7 0.0018 18.5 0.5 4.2 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX58302.1 - 7.6e-07 28.2 0.6 9e-06 24.6 1.0 2.1 2 0 0 2 2 2 1 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX58302.1 - 0.0026 17.7 0.5 0.026 14.4 0.2 2.6 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A MFS_2 PF13347.6 ORX58303.1 - 2.8e-13 49.3 6.6 2.8e-13 49.3 6.6 3.4 3 1 0 3 3 3 1 MFS/sugar transport protein MFS_1_like PF12832.7 ORX58303.1 - 0.043 12.7 9.4 0.039 12.8 0.4 2.6 1 1 1 2 2 2 0 MFS_1 like family AKAP7_NLS PF10469.9 ORX58304.1 - 9.1e-07 29.0 0.0 1.1e-06 28.8 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Rrp15p PF07890.12 ORX58305.1 - 3e-36 124.7 5.0 3.7e-36 124.4 5.0 1.0 1 0 0 1 1 1 1 Rrp15p SPG4 PF17325.2 ORX58305.1 - 0.28 12.3 2.0 0.26 12.4 0.5 1.6 1 1 1 2 2 2 0 Stationary phase protein 4 SVIP PF15811.5 ORX58305.1 - 0.3 11.5 3.2 0.59 10.6 0.4 2.3 2 0 0 2 2 2 0 Small VCP/p97-interacting protein GAT PF03127.14 ORX58306.1 - 4.3e-09 36.5 0.5 1.9e-08 34.5 0.5 2.2 1 0 0 1 1 1 1 GAT domain LRR_6 PF13516.6 ORX58306.1 - 6.1e-07 29.0 27.2 0.28 11.4 0.2 9.3 10 0 0 10 10 10 3 Leucine Rich repeat Mn_catalase PF05067.12 ORX58306.1 - 0.15 11.1 0.6 0.46 9.4 0.0 1.9 2 0 0 2 2 2 0 Manganese containing catalase LRR_1 PF00560.33 ORX58306.1 - 0.15 12.7 24.2 18 6.4 0.0 9.2 11 0 0 11 11 11 0 Leucine Rich Repeat LRR_4 PF12799.7 ORX58306.1 - 0.2 12.2 32.0 1.2 9.6 1.0 7.2 3 2 6 9 9 9 0 Leucine Rich repeats (2 copies) Exo_endo_phos PF03372.23 ORX58307.1 - 1.8e-21 76.7 0.0 2.9e-21 76.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 ORX58307.1 - 7.1e-10 39.0 2.7 2.7e-05 24.4 0.1 2.6 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX58307.1 - 3.3e-09 36.4 3.6 2.3e-06 27.3 0.2 2.4 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 ORX58307.1 - 0.0028 18.0 0.7 12 6.9 0.0 4.5 4 0 0 4 4 4 1 Leucine Rich Repeat DFP PF04127.15 ORX58308.1 - 4.2e-20 72.4 0.0 4.9e-11 42.8 0.0 2.2 1 1 1 2 2 2 2 DNA / pantothenate metabolism flavoprotein Glyco_hydro_67C PF07477.12 ORX58308.1 - 0.074 12.6 0.4 0.83 9.1 0.0 2.3 3 0 0 3 3 3 0 Glycosyl hydrolase family 67 C-terminus SIS PF01380.22 ORX58309.1 - 7.9e-26 90.5 0.1 4.8e-25 87.9 0.0 2.2 2 1 1 3 3 3 1 SIS domain SIS_2 PF13580.6 ORX58309.1 - 6.5e-10 39.2 0.3 4.5e-05 23.5 0.2 2.5 1 1 1 2 2 2 2 SIS domain CBS PF00571.28 ORX58309.1 - 4e-08 33.6 0.1 7.2e-07 29.6 0.0 3.0 3 0 0 3 3 3 1 CBS domain DUF2529 PF10740.9 ORX58309.1 - 0.083 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2529) HlyIII PF03006.20 ORX58310.1 - 4.1e-53 180.4 16.4 5.1e-53 180.1 16.4 1.1 1 0 0 1 1 1 1 Haemolysin-III related FUSC PF04632.12 ORX58310.1 - 0.053 12.1 0.2 0.072 11.6 0.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DHC_N1 PF08385.12 ORX58310.1 - 0.18 10.4 3.9 0.27 9.8 3.9 1.1 1 0 0 1 1 1 0 Dynein heavy chain, N-terminal region 1 Pyridox_ox_2 PF12900.7 ORX58311.1 - 1.7e-35 122.0 0.1 2.4e-35 121.6 0.1 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ORX58311.1 - 0.0038 17.4 0.0 0.0064 16.7 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase NMD3 PF04981.13 ORX58312.1 - 1.1e-81 273.9 5.5 1.6e-81 273.4 5.5 1.2 1 0 0 1 1 1 1 NMD3 family HLH PF00010.26 ORX58313.1 - 1.9e-15 56.5 0.4 3.7e-15 55.6 0.4 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Med19 PF10278.9 ORX58313.1 - 0.04 13.8 0.3 0.063 13.2 0.3 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 PEHE PF15275.6 ORX58313.1 - 0.4 11.3 4.1 0.43 11.2 3.4 1.4 1 1 0 1 1 1 0 PEHE domain AKAP7_NLS PF10469.9 ORX58314.1 - 6.3e-39 134.0 0.0 8.3e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain KH_1 PF00013.29 ORX58314.1 - 3.7e-14 52.3 0.0 8.3e-14 51.2 0.0 1.6 1 0 0 1 1 1 1 KH domain SLS PF14611.6 ORX58314.1 - 8.9e-05 22.4 0.0 0.00014 21.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator KH_2 PF07650.17 ORX58314.1 - 0.022 14.6 0.1 0.052 13.4 0.1 1.6 1 0 0 1 1 1 0 KH domain DUF3029 PF11230.8 ORX58314.1 - 0.066 11.6 0.0 0.099 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3029) Peptidase_M24 PF00557.24 ORX58315.1 - 2.5e-56 190.7 0.1 3.1e-56 190.4 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 ORX58315.1 - 5.2e-21 74.7 8.8 1.4e-20 73.4 8.8 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ORX58315.1 - 6.4e-05 23.0 6.3 0.00014 21.8 6.3 1.6 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 ORX58315.1 - 0.015 15.1 6.3 0.035 14.0 6.3 1.7 1 0 0 1 1 1 0 HIT zinc finger Ion_trans PF00520.31 ORX58316.1 - 2.9e-102 341.1 93.7 4.1e-34 117.9 14.3 5.2 5 0 0 5 5 5 5 Ion transport protein GPHH PF16905.5 ORX58316.1 - 0.0017 18.1 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Renin_r PF07850.14 ORX58316.1 - 1.8 9.2 7.6 0.15 12.7 1.5 2.5 2 0 0 2 2 2 0 Renin receptor-like protein MA3 PF02847.17 ORX58318.1 - 2.4e-29 101.6 0.2 5.2e-29 100.5 0.2 1.6 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 ORX58318.1 - 3.3e-11 43.2 1.5 3.4e-11 43.2 0.1 1.8 2 0 0 2 2 2 1 MIF4G domain Vac14_Fab1_bd PF12755.7 ORX58318.1 - 0.064 13.9 0.2 1.5 9.5 0.0 2.6 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Thr_synth_N PF14821.6 ORX58318.1 - 0.11 12.7 0.0 0.83 9.9 0.0 2.2 2 0 0 2 2 2 0 Threonine synthase N terminus Spec3 PF15795.5 ORX58318.1 - 0.2 12.2 0.5 0.38 11.3 0.5 1.4 1 0 0 1 1 1 0 Ectodermal ciliogenesis protein Serglycin PF04360.12 ORX58318.1 - 1.7 8.6 15.9 1.9 8.4 9.1 2.4 2 0 0 2 2 2 0 Serglycin Herpes_pp85 PF04637.12 ORX58320.1 - 0.64 8.4 4.5 0.8 8.1 4.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) ArfGap PF01412.18 ORX58321.1 - 3e-42 143.4 1.3 3.6e-42 143.1 1.3 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Gal4_dimer PF03902.13 ORX58321.1 - 0.047 13.9 0.1 0.18 12.0 0.1 1.9 2 0 0 2 2 2 0 Gal4-like dimerisation domain zf-RRN7 PF11781.8 ORX58321.1 - 0.32 10.7 1.5 0.49 10.1 1.5 1.3 1 0 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DNA_pol_E_B PF04042.16 ORX58322.1 - 5.7e-53 179.4 0.0 8.2e-53 178.9 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 ORX58322.1 - 0.00074 19.6 0.4 0.0066 16.5 0.0 2.4 2 1 0 3 3 3 1 DNA polymerase delta subunit OB-fold domain BOF PF04076.13 ORX58322.1 - 0.097 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein DUF974 PF06159.13 ORX58323.1 - 3.5e-68 230.1 0.0 8.8e-68 228.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF974) Trs65 PF12735.7 ORX58323.1 - 1.3e-07 31.4 0.5 0.00099 18.6 0.1 2.8 2 1 0 3 3 3 2 TRAPP trafficking subunit Trs65 TRAPPC9-Trs120 PF08626.11 ORX58323.1 - 0.008 13.6 0.0 0.012 13.0 0.0 1.2 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Transglut_C PF00927.22 ORX58323.1 - 0.011 15.9 0.0 0.026 14.7 0.0 1.6 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain ACBP PF00887.19 ORX58324.1 - 0.0039 17.4 0.2 0.019 15.2 0.0 2.2 2 0 0 2 2 2 1 Acyl CoA binding protein AATF-Che1 PF13339.6 ORX58324.1 - 0.15 12.7 2.0 4.5 8.0 0.1 2.5 2 1 0 2 2 2 0 Apoptosis antagonizing transcription factor Utp21 PF04192.12 ORX58325.1 - 4.5e-65 219.4 3.9 6.9e-65 218.8 3.9 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 ORX58325.1 - 6e-27 93.4 12.9 4.3e-07 30.5 0.2 8.7 9 0 0 9 9 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58325.1 - 7.6e-24 83.8 1.4 0.00056 20.1 0.2 8.4 2 2 6 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX58325.1 - 1.8e-05 23.6 16.5 0.026 13.2 0.1 6.0 3 3 4 7 7 7 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX58325.1 - 5.1e-05 23.2 1.1 1.6 8.6 0.0 4.5 2 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ORX58325.1 - 9.2e-05 21.5 0.6 0.55 9.1 0.0 3.4 3 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ORX58325.1 - 0.0021 16.7 0.1 0.032 12.8 0.0 2.7 3 0 0 3 3 3 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ORX58325.1 - 0.0046 15.8 0.1 2.2 6.9 0.0 3.8 3 1 1 4 4 4 1 Nup133 N terminal like DBC1 PF14443.6 ORX58325.1 - 0.032 14.2 0.0 0.15 12.1 0.0 1.9 2 0 0 2 2 2 0 DBC1 PALB2_WD40 PF16756.5 ORX58325.1 - 0.082 11.8 0.6 0.58 9.0 0.0 2.6 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ORX58325.1 - 0.22 10.8 1.0 2.6 7.3 0.2 2.9 2 1 1 3 3 3 0 WD40-like domain Asp PF00026.23 ORX58327.1 - 1.3e-73 248.2 5.3 1.6e-73 247.9 5.3 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX58327.1 - 1.7e-15 57.7 2.9 1.1e-11 45.2 1.3 3.6 2 2 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX58327.1 - 0.0055 16.5 0.1 0.011 15.6 0.1 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ORX58327.1 - 0.0066 17.0 0.0 8.9 7.0 0.0 3.4 3 1 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ORX58327.1 - 0.022 15.4 0.3 13 6.5 0.0 3.4 2 1 0 2 2 2 0 Aspartyl protease Asp PF00026.23 ORX58328.1 - 1.8e-68 231.3 0.0 7.7e-68 229.2 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX58328.1 - 3.4e-13 50.2 0.6 7.3e-09 36.1 0.1 3.3 2 2 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX58328.1 - 0.022 15.4 0.6 2.9 8.6 0.0 3.0 2 1 0 2 2 2 0 Aspartyl protease Asp PF00026.23 ORX58329.1 - 3.3e-57 194.3 0.0 4.2e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX58329.1 - 7.9e-11 42.5 0.1 7.6e-09 36.0 0.1 2.6 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX58329.1 - 0.00022 21.0 0.0 0.0017 18.2 0.0 2.2 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 ORX58329.1 - 0.0012 19.5 0.3 0.073 13.7 0.0 3.0 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX58329.1 - 0.01 16.3 0.0 0.78 10.4 0.0 3.0 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease B-block_TFIIIC PF04182.12 ORX58331.1 - 5.1e-08 33.0 0.0 1.9e-05 24.7 0.0 3.4 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC MarR_2 PF12802.7 ORX58331.1 - 0.079 12.9 0.0 4.2 7.3 0.0 3.2 3 0 0 3 3 3 0 MarR family HTH_24 PF13412.6 ORX58331.1 - 0.083 12.5 0.0 2.3 7.8 0.0 2.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Peptidase_S8 PF00082.22 ORX58332.1 - 1.7e-40 139.2 0.1 7.3e-40 137.1 0.1 2.0 1 1 0 1 1 1 1 Subtilase family fn3_5 PF06280.12 ORX58332.1 - 6.2e-13 49.4 0.4 1.6e-12 48.1 0.4 1.8 1 0 0 1 1 1 1 Fn3-like domain PA PF02225.22 ORX58332.1 - 4.5e-07 29.8 0.6 1.2e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 PA domain Motile_Sperm PF00635.26 ORX58332.1 - 0.0026 17.6 1.1 0.23 11.3 0.3 2.5 2 0 0 2 2 2 2 MSP (Major sperm protein) domain Ifi-6-16 PF06140.13 ORX58332.1 - 0.043 13.7 0.1 0.043 13.7 0.1 3.4 4 0 0 4 4 4 0 Interferon-induced 6-16 family DNA_pol_viral_C PF00336.18 ORX58334.1 - 0.00069 19.1 0.0 0.00082 18.8 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase (viral) C-terminal domain Dam PF05869.11 ORX58334.1 - 0.0094 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 DNA N-6-adenine-methyltransferase (Dam) OrfB_Zn_ribbon PF07282.11 ORX58335.1 - 1e-10 41.4 3.1 3.8e-10 39.5 1.1 2.4 2 0 0 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX58335.1 - 0.6 10.2 4.4 1.2 9.2 4.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF2777 PF10949.8 ORX58337.1 - 0.009 15.7 0.1 29 4.2 0.2 4.5 2 1 2 6 6 6 1 Protein of unknown function (DUF2777) Mrx7 PF10906.8 ORX58337.1 - 0.28 11.5 36.7 2e+02 2.3 0.0 12.7 3 2 11 14 14 14 0 MIOREX complex component 7 PDH PF02153.17 ORX58338.1 - 9e-17 60.9 0.2 1.4e-16 60.3 0.2 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase F420_oxidored PF03807.17 ORX58338.1 - 3.9e-06 27.4 0.0 8.1e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ORX58338.1 - 0.0002 21.5 0.0 0.00037 20.7 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ORX58338.1 - 0.0004 20.1 0.0 0.0011 18.6 0.0 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 ORX58338.1 - 0.0057 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ORX58338.1 - 0.02 14.3 0.0 0.033 13.5 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ORX58338.1 - 0.022 14.6 0.1 0.087 12.7 0.1 2.0 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PglD_N PF17836.1 ORX58338.1 - 0.038 14.6 0.0 0.13 13.0 0.0 1.9 2 0 0 2 2 2 0 PglD N-terminal domain OrfB_Zn_ribbon PF07282.11 ORX58661.1 - 0.026 14.4 0.4 0.087 12.8 0.4 2.0 1 0 0 1 1 1 0 Putative transposase DNA-binding domain CK1gamma_C PF12605.8 ORX58661.1 - 1.6 9.9 5.5 0.94 10.7 1.1 2.6 2 0 0 2 2 2 0 Casein kinase 1 gamma C terminal MarR PF01047.22 ORX58663.1 - 3.7e-05 23.6 0.0 6.5e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 MarR family B-block_TFIIIC PF04182.12 ORX58663.1 - 6.4e-05 23.0 0.0 0.00011 22.3 0.0 1.4 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC Rrf2 PF02082.20 ORX58663.1 - 0.00024 21.4 0.1 0.00042 20.6 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator HTH_Crp_2 PF13545.6 ORX58663.1 - 0.00052 19.9 0.0 0.00086 19.2 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain MarR_2 PF12802.7 ORX58663.1 - 0.0024 17.7 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_micro PF17007.5 ORX58663.1 - 0.0057 15.5 0.0 0.0069 15.2 0.0 1.1 1 0 0 1 1 1 1 HTH-like Fe_dep_repress PF01325.19 ORX58663.1 - 0.0096 16.1 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain ABC_tran PF00005.27 ORX58664.1 - 1.2e-23 84.1 0.0 3.1e-23 82.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter ABC_ATPase PF09818.9 ORX58664.1 - 1.5e-05 24.1 0.0 6.7e-05 21.9 0.0 1.8 1 1 1 2 2 2 1 Predicted ATPase of the ABC class SMC_N PF02463.19 ORX58664.1 - 2.7e-05 23.7 1.7 0.00014 21.4 0.1 2.0 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_membrane PF00664.23 ORX58664.1 - 8.3e-05 22.4 0.5 0.00013 21.7 0.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA PF00004.29 ORX58664.1 - 0.0011 19.4 0.4 0.0044 17.4 0.4 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX58664.1 - 0.0023 18.2 0.1 0.0076 16.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain SbcCD_C PF13558.6 ORX58664.1 - 0.01 16.0 0.7 0.15 12.3 0.7 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit GMC_oxred_N PF00732.19 ORX58664.1 - 0.036 13.4 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 GMC oxidoreductase AAA_24 PF13479.6 ORX58664.1 - 0.037 13.8 0.0 0.071 12.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ORX58664.1 - 0.1 13.0 0.3 0.34 11.3 0.3 1.8 1 1 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 ORX58664.1 - 0.14 12.0 0.1 0.66 9.9 0.0 2.0 2 0 0 2 2 2 0 Rad17 P-loop domain SOG2 PF10428.9 ORX58666.1 - 1.7 7.7 15.4 2.2 7.4 15.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein VCBS PF13517.6 ORX58666.1 - 6 7.5 6.1 1.1e+02 3.6 0.1 3.7 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella ABC_tran PF00005.27 ORX58667.1 - 6.9e-21 75.2 0.0 1.3e-20 74.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX58667.1 - 2.4e-16 60.2 0.7 3.4e-16 59.7 0.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX58667.1 - 2e-06 27.4 0.1 0.0048 16.4 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX58667.1 - 2.3e-05 24.8 0.0 5.2e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ORX58667.1 - 0.00049 19.8 0.1 0.0011 18.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX58667.1 - 0.00088 19.6 0.3 0.0075 16.6 0.2 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX58667.1 - 0.0011 18.7 0.5 0.12 12.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ORX58667.1 - 0.0023 17.8 0.0 0.0046 16.8 0.0 1.5 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system ATP-synt_ab PF00006.25 ORX58667.1 - 0.0036 17.0 0.0 0.0052 16.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain RsgA_GTPase PF03193.16 ORX58667.1 - 0.016 15.1 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 ORX58667.1 - 0.018 14.6 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 ORX58667.1 - 0.04 13.9 0.1 0.21 11.6 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_15 PF13175.6 ORX58667.1 - 0.046 13.4 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ORX58667.1 - 0.048 13.2 0.1 0.12 12.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 ORX58667.1 - 0.061 13.8 0.0 4.7 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ORX58667.1 - 0.11 12.6 0.1 0.42 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX58667.1 - 0.13 11.5 0.3 0.59 9.4 0.1 2.0 2 0 0 2 2 2 0 Zeta toxin DUF87 PF01935.17 ORX58667.1 - 0.14 12.3 0.2 0.29 11.2 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_18 PF13238.6 ORX58667.1 - 0.16 12.5 0.1 0.44 11.1 0.1 1.8 1 1 0 1 1 1 0 AAA domain Glyco_hydro_31 PF01055.26 ORX58668.1 - 5.9e-141 470.6 6.6 7.6e-141 470.3 6.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX58668.1 - 1.3e-30 105.9 0.1 2.7e-30 104.9 0.1 1.5 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX58668.1 - 5.9e-08 32.9 4.8 1.3e-07 31.8 0.2 3.3 3 0 0 3 3 3 1 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 ORX58669.1 - 8.1e-141 470.2 2.4 1e-140 469.9 2.4 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 ORX58669.1 - 5.1e-31 107.3 0.5 1e-30 106.3 0.5 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 ORX58669.1 - 4.9e-09 36.4 1.9 2.8e-07 30.7 0.2 2.9 3 0 0 3 3 3 2 Galactose mutarotase-like Kinesin PF00225.23 ORX58670.1 - 5.9e-112 373.9 0.2 9.8e-112 373.2 0.2 1.4 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ORX58670.1 - 8.2e-42 143.4 0.0 2.5e-41 141.8 0.0 1.9 1 0 0 1 1 1 1 Kinesin-associated DUF3694 PF12473.8 ORX58670.1 - 3e-30 105.9 1.8 9.5e-30 104.3 1.8 2.0 1 0 0 1 1 1 1 Kinesin protein Microtub_bd PF16796.5 ORX58670.1 - 5.8e-27 94.5 0.0 1.4e-26 93.2 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding PH PF00169.29 ORX58670.1 - 1.7e-10 41.3 0.0 4.9e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 PH domain FHA PF00498.26 ORX58670.1 - 3.7e-05 24.0 0.1 0.00033 20.9 0.1 2.7 2 0 0 2 2 2 1 FHA domain KIF1B PF12423.8 ORX58670.1 - 0.00012 22.5 0.5 0.00012 22.5 0.5 3.1 3 0 0 3 3 3 1 Kinesin protein 1B Kinesin PF00225.23 ORX58671.1 - 1.4e-86 290.4 1.9 1.4e-86 290.4 1.9 2.9 2 2 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX58671.1 - 9.7e-13 48.3 0.5 2.4e-11 43.8 0.0 3.0 2 1 0 2 2 2 1 Microtubule binding Prominin PF05478.11 ORX58671.1 - 0.45 8.4 18.9 0.0084 14.1 9.0 2.1 1 1 1 2 2 2 0 Prominin DUF4239 PF14023.6 ORX58671.1 - 1.1 9.0 7.4 0.14 11.9 2.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) GATA PF00320.27 ORX58672.1 - 1.4e-28 98.2 13.5 1e-14 53.8 3.9 2.6 2 0 0 2 2 2 2 GATA zinc finger DUF1752 PF08550.10 ORX58672.1 - 3.9e-12 45.8 2.3 8.6e-12 44.7 1.5 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) TF_Zn_Ribbon PF08271.12 ORX58672.1 - 0.0012 18.3 3.7 0.14 11.7 0.3 2.4 2 0 0 2 2 2 2 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 ORX58672.1 - 0.0014 18.7 0.5 0.62 10.2 0.1 2.8 2 0 0 2 2 2 1 Zinc ribbon domain DZR PF12773.7 ORX58672.1 - 0.0017 18.4 1.2 0.0099 15.9 0.9 2.5 1 1 1 2 2 2 1 Double zinc ribbon HNH PF01844.23 ORX58672.1 - 0.23 11.7 1.6 0.7 10.1 0.3 2.5 2 0 0 2 2 2 0 HNH endonuclease OTT_1508_deam PF14441.6 ORX58672.1 - 0.33 11.0 1.7 25 5.0 0.1 2.9 2 0 0 2 2 2 0 OTT_1508-like deaminase FYVE PF01363.21 ORX58672.1 - 0.5 10.5 3.9 13 6.0 3.2 2.9 2 1 0 2 2 2 0 FYVE zinc finger Auto_anti-p27 PF06677.12 ORX58672.1 - 0.62 10.3 4.8 11 6.3 0.5 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zinc_ribbon_15 PF17032.5 ORX58672.1 - 0.84 10.4 4.6 6.2 7.6 3.2 2.9 1 1 2 3 3 3 0 zinc-ribbon family eIF-5_eIF-2B PF01873.17 ORX58672.1 - 1.2 9.0 4.5 10 6.0 0.4 2.8 2 0 0 2 2 2 0 Domain found in IF2B/IF5 HNH_5 PF14279.6 ORX58672.1 - 3.7 7.5 4.9 1.2 9.1 0.2 2.6 1 1 1 3 3 3 0 HNH endonuclease EMP70 PF02990.16 ORX58674.1 - 3.7e-136 454.8 10.4 4.4e-136 454.6 10.4 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 PEX11 PF05648.14 ORX58675.1 - 1.6e-14 53.9 0.6 2.3e-13 50.2 0.6 2.2 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) NUDIX PF00293.28 ORX58676.1 - 1.5e-09 38.0 0.0 2.2e-09 37.5 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF4999 PF16390.5 ORX58676.1 - 0.11 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function EF-hand_6 PF13405.6 ORX58677.1 - 2.1e-07 30.3 2.0 1.6e-05 24.5 0.2 2.7 1 1 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ORX58677.1 - 5.6e-07 29.9 1.6 9.3e-07 29.2 1.6 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ORX58677.1 - 0.00045 19.6 2.0 0.0022 17.4 0.1 2.7 3 0 0 3 3 3 1 EF hand EF_assoc_1 PF08355.12 ORX58677.1 - 0.0017 17.9 0.0 0.0023 17.5 0.0 1.2 1 0 0 1 1 1 1 EF hand associated EF-hand_5 PF13202.6 ORX58677.1 - 0.008 15.6 1.5 0.015 14.8 0.2 2.2 2 0 0 2 2 2 1 EF hand DUF3976 PF13121.6 ORX58677.1 - 0.082 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3976) HSM3_C PF18794.1 ORX58677.1 - 0.09 12.4 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 DNA mismatch repair protein HSM3, C terminal domain ThiF PF00899.21 ORX58678.1 - 9.3e-69 231.5 0.0 2.8e-68 229.9 0.0 1.6 1 1 1 2 2 2 1 ThiF family E2_bind PF08825.10 ORX58678.1 - 1.6e-30 105.1 0.6 2.4e-30 104.5 0.6 1.3 1 0 0 1 1 1 1 E2 binding domain Shikimate_DH PF01488.20 ORX58678.1 - 0.00024 21.2 0.0 0.00051 20.1 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase E1_UFD PF09358.10 ORX58678.1 - 0.11 13.2 0.1 0.31 11.8 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin fold domain zf-C3HC4_3 PF13920.6 ORX58678.1 - 0.13 12.2 0.5 13 5.8 0.1 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pyr_redox PF00070.27 ORX58678.1 - 0.13 12.8 0.0 0.26 11.9 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ORX58678.1 - 0.15 12.6 0.0 0.38 11.2 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Ecm33 PF12454.8 ORX58678.1 - 0.85 9.8 6.8 0.15 12.3 2.3 2.0 2 0 0 2 2 2 0 GPI-anchored cell wall organization protein Metallophos PF00149.28 ORX58679.1 - 9.1e-37 127.5 0.3 1.3e-36 127.1 0.3 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX58679.1 - 0.00015 22.2 0.0 0.00029 21.2 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain cwf21 PF08312.12 ORX58679.1 - 0.16 12.1 0.8 0.28 11.4 0.8 1.4 1 0 0 1 1 1 0 cwf21 domain SNF2_N PF00176.23 ORX58680.1 - 6e-72 242.3 1.1 6e-72 242.3 1.1 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 ORX58680.1 - 2.2e-20 72.5 0.6 6.7e-20 71.0 0.6 1.8 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 ORX58680.1 - 5.3e-20 71.8 0.1 7.7e-19 68.1 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 ORX58680.1 - 1.4e-16 60.6 12.0 1.4e-16 60.6 12.0 3.3 3 1 1 4 4 4 1 HSA SnAC PF14619.6 ORX58680.1 - 1.5e-14 54.3 1.2 1.5e-14 54.3 1.2 2.7 2 0 0 2 2 2 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 ORX58680.1 - 3.4e-08 33.7 0.0 3.4e-08 33.7 0.0 3.3 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit PRAI PF00697.22 ORX58680.1 - 0.17 11.6 2.5 0.43 10.3 2.5 1.6 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase PRT_C PF08372.10 ORX58681.1 - 3.8e-05 23.5 0.1 3.8e-05 23.5 0.1 1.8 2 0 0 2 2 2 1 Plant phosphoribosyltransferase C-terminal DUF3292 PF11696.8 ORX58681.1 - 0.0068 14.8 3.7 0.57 8.5 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3292) Adeno_Penton_B PF01686.17 ORX58683.1 - 0.17 10.4 0.0 0.24 9.9 0.0 1.1 1 0 0 1 1 1 0 Adenovirus penton base protein Ribosomal_S8e PF01201.22 ORX58684.1 - 5.5e-54 182.1 1.0 8.3e-54 181.5 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8e Pup PF05639.11 ORX58684.1 - 0.1 13.5 1.7 0.2 12.6 1.7 1.4 1 0 0 1 1 1 0 Pup-like protein Ribosomal_L5_C PF00673.21 ORX58685.1 - 7.6e-22 77.3 0.0 1.1e-21 76.7 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 ORX58685.1 - 2.4e-18 66.2 0.1 8.2e-18 64.5 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 ORX58685.1 - 0.18 11.6 0.1 0.35 10.6 0.1 1.4 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain DUF3180 PF11377.8 ORX58686.1 - 0.15 12.2 2.5 0.73 10.0 0.4 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3180) Wzy_C PF04932.15 ORX58686.1 - 3.5 7.2 13.0 0.52 9.9 0.5 2.7 2 1 0 2 2 2 0 O-Antigen ligase Pyr_redox_2 PF07992.14 ORX58687.1 - 1.7e-49 168.6 0.0 2e-49 168.4 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX58687.1 - 3.7e-10 40.2 0.0 1.3e-06 28.9 0.0 2.7 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX58687.1 - 0.0096 15.5 0.0 0.77 9.3 0.0 2.4 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX58687.1 - 0.066 13.7 0.1 0.4 11.2 0.0 2.2 2 1 0 2 2 2 0 Putative NAD(P)-binding FAD_syn PF06574.12 ORX58687.1 - 0.071 13.0 0.0 0.19 11.6 0.0 1.6 2 0 0 2 2 2 0 FAD synthetase Pyr_redox_3 PF13738.6 ORX58687.1 - 0.12 11.6 0.0 10 5.3 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase VTC PF09359.10 ORX58688.1 - 2e-100 335.7 0.2 2.8e-100 335.2 0.2 1.2 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 ORX58688.1 - 1.5e-16 61.3 11.1 2.2e-06 27.9 0.1 4.1 3 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 ORX58688.1 - 7.5e-15 55.1 0.8 7.5e-15 55.1 0.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) RED_N PF07808.13 ORX58689.1 - 4.2e-29 101.8 6.8 4.2e-29 101.8 6.8 3.6 3 1 0 3 3 3 1 RED-like protein N-terminal region RED_C PF07807.11 ORX58689.1 - 6.1e-20 71.8 6.6 6.1e-20 71.8 6.6 3.2 3 1 0 3 3 3 1 RED-like protein C-terminal region DUF3446 PF11928.8 ORX58689.1 - 0.15 12.4 3.5 0.33 11.3 3.5 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain Ndc1_Nup PF09531.10 ORX58689.1 - 0.21 10.2 4.9 0.056 12.1 0.3 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup AMP-binding PF00501.28 ORX58690.1 - 1.5e-96 323.6 0.0 1.9e-96 323.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX58690.1 - 1.2e-24 87.1 0.0 3.4e-24 85.6 0.0 1.9 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ORX58690.1 - 5.1e-18 64.7 0.2 5.1e-18 64.7 0.2 3.0 3 0 0 3 3 3 1 Acetyl-coenzyme A synthetase N-terminus YjcQ PF09639.10 ORX58691.1 - 0.022 14.9 0.1 0.051 13.8 0.1 1.7 1 0 0 1 1 1 0 YjcQ protein Nbl1_Borealin_N PF10444.9 ORX58691.1 - 0.26 10.9 6.2 2.2 8.0 0.7 3.0 3 0 0 3 3 3 0 Nbl1 / Borealin N terminal Spc7 PF08317.11 ORX58691.1 - 0.56 9.0 14.3 1.2 7.9 4.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein Uso1_p115_C PF04871.13 ORX58691.1 - 0.89 9.9 8.0 3.6 8.0 1.0 2.4 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4763 PF15960.5 ORX58691.1 - 0.91 8.8 16.4 2.5 7.3 11.7 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) zf-ZPR1 PF03367.13 ORX58691.1 - 1.2 9.0 3.7 0.89 9.4 0.3 1.9 2 0 0 2 2 2 0 ZPR1 zinc-finger domain SlyX PF04102.12 ORX58691.1 - 3 8.5 15.8 4.9 7.8 3.2 3.7 3 1 0 3 3 3 0 SlyX HOOK PF05622.12 ORX58692.1 - 2.9e-21 75.3 3.7 3.3e-21 75.1 3.7 1.0 1 0 0 1 1 1 1 HOOK protein RB_A PF01858.17 ORX58692.1 - 0.00062 19.7 0.3 0.0013 18.6 0.1 1.6 1 1 1 2 2 2 1 Retinoblastoma-associated protein A domain Phage_GPO PF05929.11 ORX58692.1 - 0.0095 15.6 2.5 0.012 15.2 2.5 1.1 1 0 0 1 1 1 1 Phage capsid scaffolding protein (GPO) serine peptidase MCM_N PF14551.6 ORX58692.1 - 0.11 13.1 1.0 0.42 11.2 0.1 2.2 2 0 0 2 2 2 0 MCM N-terminal domain Lipoprotein_6 PF01441.19 ORX58693.1 - 1.4 8.9 8.2 0.6 10.1 5.2 1.8 2 0 0 2 2 2 0 Lipoprotein Snapin_Pallidin PF14712.6 ORX58693.1 - 4.9 7.6 13.9 5.9 7.4 0.5 3.8 3 1 0 3 3 3 0 Snapin/Pallidin FAM76 PF16046.5 ORX58693.1 - 8.5 5.6 27.4 0.07 12.5 16.8 2.3 1 1 1 2 2 2 0 FAM76 protein Rieske PF00355.26 ORX58694.1 - 0.00018 21.3 0.1 0.0003 20.7 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Acetyltransf_10 PF13673.7 ORX58695.1 - 1.7e-06 28.0 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX58695.1 - 3.2e-05 24.1 0.0 4.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX58695.1 - 0.00075 19.9 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX58695.1 - 0.0021 18.0 0.1 0.005 16.8 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein NFACT-R_1 PF05670.13 ORX58696.1 - 3.8e-42 143.4 0.0 7.8e-42 142.4 0.0 1.5 1 0 0 1 1 1 1 NFACT protein RNA binding domain YscJ_FliF PF01514.17 ORX58696.1 - 0.049 13.3 0.1 0.27 10.9 0.0 2.0 2 1 0 2 2 2 0 Secretory protein of YscJ/FliF family Val_tRNA-synt_C PF10458.9 ORX58696.1 - 0.45 10.8 11.1 3.4 8.0 9.6 2.6 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm BING4CT PF08149.11 ORX58696.1 - 4.6 7.1 5.2 3.3 7.6 1.0 2.4 2 0 0 2 2 2 0 BING4CT (NUC141) domain tRNA-synt_2b PF00587.25 ORX58697.1 - 1.5e-43 148.8 0.0 5.1e-43 147.1 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ORX58697.1 - 1.9e-16 60.0 0.0 3.1e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_His PF13393.6 ORX58697.1 - 0.01 15.1 0.0 0.044 13.0 0.0 1.9 2 0 0 2 2 2 0 Histidyl-tRNA synthetase SARAF PF06682.12 ORX58700.1 - 0.41 10.2 5.9 0.049 13.3 2.0 1.4 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Med7 PF05983.11 ORX58700.1 - 2.9 7.9 15.8 5.1 7.1 15.8 1.3 1 1 0 1 1 1 0 MED7 protein Comm PF15957.5 ORX58700.1 - 3.8 7.9 5.8 0.71 10.2 1.1 2.0 2 1 0 2 2 2 0 Commissureless Mre11_DNA_bind PF04152.14 ORX58701.1 - 1.7e-45 155.3 0.3 3.9e-45 154.2 0.3 1.6 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ORX58701.1 - 3.4e-14 53.8 4.7 6.9e-14 52.8 4.7 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX58701.1 - 4.2e-05 23.8 0.0 0.00059 20.1 0.0 2.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SKN1 PF03935.15 ORX58703.1 - 0.049 12.0 0.0 0.056 11.8 0.0 1.1 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) Med17 PF10156.9 ORX58704.1 - 8.8e-78 262.1 0.5 1.4e-77 261.3 0.5 1.3 1 0 0 1 1 1 1 Subunit 17 of Mediator complex BAG PF02179.16 ORX58706.1 - 3.2e-13 49.9 0.3 4.7e-13 49.4 0.3 1.3 1 0 0 1 1 1 1 BAG domain NDC10_II PF16787.5 ORX58706.1 - 0.019 14.1 0.1 0.023 13.7 0.1 1.1 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 DASH_Ask1 PF08655.10 ORX58706.1 - 0.095 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 DASH complex subunit Ask1 Uteroglobin PF01099.17 ORX58706.1 - 0.13 12.6 0.3 0.22 11.9 0.3 1.3 1 0 0 1 1 1 0 Uteroglobin family IncD PF17628.2 ORX58706.1 - 0.17 11.7 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Inclusion membrane protein D Ribosomal_L22 PF00237.19 ORX58707.1 - 1.4e-22 79.9 0.4 2.1e-22 79.3 0.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF680 PF05079.12 ORX58707.1 - 0.085 13.6 0.2 0.61 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF680) E1-E2_ATPase PF00122.20 ORX58708.1 - 2.9e-53 180.1 3.8 1.9e-52 177.4 0.5 2.9 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX58708.1 - 4e-47 160.3 8.8 4e-47 160.3 8.8 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX58708.1 - 7.6e-22 78.6 5.3 1.4e-21 77.7 3.6 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX58708.1 - 7.8e-22 77.2 0.1 1.6e-21 76.2 0.1 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX58708.1 - 6.1e-16 57.9 2.0 7.7e-16 57.5 0.1 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX58708.1 - 3.7e-06 26.9 3.5 0.0002 21.2 1.8 2.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX58708.1 - 5.3e-06 27.0 0.0 1.5e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase VPS11_C PF12451.8 ORX58708.1 - 0.1 12.9 0.1 0.24 11.6 0.1 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal BCS1_N PF08740.11 ORX58709.1 - 2e-44 151.8 0.6 3.9e-44 150.9 0.6 1.5 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 ORX58709.1 - 1.2e-19 71.0 0.0 2.5e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ORX58709.1 - 0.0011 18.2 0.0 0.0035 16.5 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase PF06745.13 ORX58709.1 - 0.013 14.8 0.0 0.073 12.4 0.0 2.0 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 ORX58709.1 - 0.029 14.5 0.1 0.074 13.2 0.0 1.9 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ORX58709.1 - 0.072 13.1 0.0 0.17 11.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 ORX58709.1 - 0.1 12.4 0.2 0.19 11.5 0.2 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 ORX58709.1 - 0.11 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX58709.1 - 0.12 12.7 0.1 2 8.8 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 ORX58709.1 - 0.18 12.4 0.6 2.6 8.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain DeoC PF01791.9 ORX58710.1 - 1.2e-19 70.9 1.9 1.5e-19 70.5 1.9 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase Prenyltransf PF01255.19 ORX58710.1 - 0.023 14.2 0.0 0.033 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase DHO_dh PF01180.21 ORX58710.1 - 0.054 12.7 0.2 0.089 12.0 0.1 1.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase polyprenyl_synt PF00348.17 ORX58711.1 - 5.6e-66 222.2 0.0 6.7e-66 222.0 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase adh_short_C2 PF13561.6 ORX58712.1 - 1.2e-67 227.9 1.0 1.5e-67 227.6 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX58712.1 - 3.9e-54 183.1 2.9 5.3e-54 182.7 2.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX58712.1 - 1.1e-13 51.5 0.9 1.6e-13 51.0 0.9 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 ORX58712.1 - 9.2e-05 21.9 0.0 0.00014 21.3 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 ORX58712.1 - 0.00026 20.5 0.1 0.00044 19.8 0.1 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF2046 PF09755.9 ORX58713.1 - 1.4e-38 132.8 37.9 1.4e-30 106.6 23.8 3.1 1 1 2 3 3 3 3 Uncharacterized conserved protein H4 (DUF2046) MALT1_Ig PF18703.1 ORX58713.1 - 0.23 11.5 3.6 0.67 10.0 3.6 1.8 1 0 0 1 1 1 0 MALT1 Ig-like domain DUF3619 PF12279.8 ORX58713.1 - 1.1 9.6 5.7 0.69 10.3 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) DpnI_C PF17726.1 ORX58713.1 - 3.6 7.8 6.7 5.1 7.3 0.4 2.7 2 0 0 2 2 2 0 Dam-replacing HTH domain Peptidase_S8 PF00082.22 ORX58714.1 - 2.8e-75 253.3 0.1 4.9e-75 252.6 0.1 1.3 1 0 0 1 1 1 1 Subtilase family TPPII PF12580.8 ORX58714.1 - 2.5e-48 164.1 0.0 4.5e-48 163.3 0.0 1.4 1 0 0 1 1 1 1 Tripeptidyl peptidase II YppG PF14179.6 ORX58714.1 - 0.039 14.7 1.7 0.05 14.3 0.1 2.0 2 0 0 2 2 2 0 YppG-like protein Med30 PF11315.8 ORX58714.1 - 3.4 7.8 9.4 14 5.8 1.8 2.6 2 0 0 2 2 2 0 Mediator complex subunit 30 bZIP_1 PF00170.21 ORX58714.1 - 7.9 6.7 9.3 9.9 6.3 0.5 3.1 3 0 0 3 3 3 0 bZIP transcription factor HEAT PF02985.22 ORX58715.1 - 2.9e-12 45.7 3.0 0.0017 18.5 0.1 6.5 6 0 0 6 6 6 4 HEAT repeat Cnd1 PF12717.7 ORX58715.1 - 6e-08 32.9 0.5 0.0028 17.7 0.0 3.5 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX58715.1 - 0.00016 22.0 0.0 0.19 12.1 0.0 4.3 2 2 2 4 4 4 2 HEAT repeats Adaptin_N PF01602.20 ORX58715.1 - 0.00065 18.4 5.4 0.045 12.3 0.1 2.8 2 1 0 3 3 3 2 Adaptin N terminal region GTP_EFTU PF00009.27 ORX58716.1 - 3.9e-58 196.2 0.7 5.6e-58 195.7 0.7 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ORX58716.1 - 4.9e-32 110.5 1.0 7.5e-32 110.0 0.1 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ORX58716.1 - 4.6e-17 62.2 4.2 1.1e-16 61.0 4.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX58716.1 - 1.1e-05 25.4 0.1 2e-05 24.6 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ORX58716.1 - 0.0013 18.4 0.0 0.0013 18.4 0.0 1.7 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 ORX58716.1 - 0.0022 17.9 0.3 0.0077 16.1 0.1 1.9 1 1 1 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ORX58716.1 - 0.012 15.4 0.4 4.5 7.0 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation mit_SMPDase PF14724.6 ORX58717.1 - 0.001 17.2 0.3 0.36 8.7 0.4 3.2 3 0 0 3 3 3 3 Mitochondrial-associated sphingomyelin phosphodiesterase DUF908 PF06012.12 ORX58717.1 - 3.8 6.8 9.4 2.5 7.4 0.4 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Methyltransf_28 PF02636.17 ORX58718.1 - 1.4e-64 218.3 0.2 1.9e-41 142.5 0.0 2.1 1 1 1 2 2 2 2 Putative S-adenosyl-L-methionine-dependent methyltransferase UPF0270 PF06794.12 ORX58718.1 - 0.018 15.1 0.3 0.13 12.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0270) OPT PF03169.15 ORX58719.1 - 7.2e-151 503.9 49.8 8.2e-151 503.7 49.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Glyco_transf_15 PF01793.16 ORX58720.1 - 2.2e-114 382.1 8.8 2.7e-114 381.8 8.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase OPT PF03169.15 ORX58721.1 - 7.2e-147 490.7 51.4 8.1e-147 490.5 51.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein PAP_central PF04928.17 ORX58722.1 - 3e-107 357.2 0.0 4e-107 356.8 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ORX58722.1 - 3.9e-31 108.0 0.0 6.8e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ORX58722.1 - 2.5e-10 40.5 0.0 5.5e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ORX58722.1 - 0.0058 16.4 0.0 0.015 15.1 0.0 1.6 2 0 0 2 2 2 1 Nrap protein PAP/OAS-like domain Polbeta PF18765.1 ORX58722.1 - 0.084 13.0 0.0 0.36 10.9 0.0 2.0 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Sel1 PF08238.12 ORX58723.1 - 3.5e-21 75.2 19.3 4.5e-07 30.3 0.1 6.7 7 0 0 7 7 7 5 Sel1 repeat TPR_6 PF13174.6 ORX58723.1 - 8e-05 23.0 13.2 5.5 7.9 0.4 6.4 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX58723.1 - 0.026 14.7 7.2 3.1 8.2 0.0 5.3 5 2 1 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX58723.1 - 3 8.1 6.1 1.4 9.2 0.3 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 Methyltransf_33 PF10017.9 ORX58724.1 - 7.7e-91 304.5 0.1 1.1e-90 304.0 0.1 1.2 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 ORX58724.1 - 1.4e-26 93.7 6.2 8.2e-26 91.1 6.2 2.1 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 ORX58724.1 - 2.2e-08 34.7 1.2 5.4e-08 33.4 1.2 1.7 1 0 0 1 1 1 1 DinB superfamily GNAT_acetyltr_2 PF13718.6 ORX58725.1 - 1.4e-97 325.6 0.0 1.4e-97 325.6 0.0 2.5 3 0 0 3 3 3 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 ORX58725.1 - 1.7e-86 289.8 6.2 1.7e-86 289.8 6.2 2.0 2 0 0 2 2 2 1 Possible tRNA binding domain Helicase_RecD PF05127.14 ORX58725.1 - 1e-66 224.2 0.0 3.1e-66 222.6 0.0 1.9 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 ORX58725.1 - 1.2e-33 114.9 0.4 3.8e-33 113.3 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) Acetyltransf_7 PF13508.7 ORX58725.1 - 0.028 14.8 0.0 0.19 12.2 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain AAA_19 PF13245.6 ORX58725.1 - 0.041 14.2 0.0 0.4 11.0 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ORX58725.1 - 0.094 13.0 0.0 2 8.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain Acetyltransf_1 PF00583.25 ORX58725.1 - 0.17 12.2 0.0 0.46 10.7 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family IU_nuc_hydro PF01156.19 ORX58726.1 - 3.6e-66 223.8 0.1 4.6e-66 223.5 0.1 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PBP_sp32 PF07222.12 ORX58726.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Phosphodiest PF01663.22 ORX58727.1 - 4.2e-49 168.0 1.2 3.6e-34 118.9 0.1 2.0 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Aldo_ket_red PF00248.21 ORX58728.1 - 1.3e-57 195.3 0.0 1.5e-57 195.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family TPR_2 PF07719.17 ORX58729.1 - 1.4e-25 87.3 3.4 0.0056 16.7 0.0 12.4 13 0 0 13 13 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX58729.1 - 7.9e-24 82.5 11.2 0.00059 19.5 0.1 11.1 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX58729.1 - 9.3e-17 61.3 3.2 0.00016 22.1 0.0 7.5 6 2 3 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX58729.1 - 1.4e-15 56.1 6.8 0.93 9.9 0.1 11.0 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX58729.1 - 2.4e-12 47.0 11.6 0.9 9.9 0.0 9.8 8 3 2 10 10 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX58729.1 - 1.2e-11 43.7 2.1 1.6 8.9 0.0 8.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX58729.1 - 1.7e-10 41.3 0.0 0.21 12.3 0.0 6.4 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX58729.1 - 4e-09 36.2 0.3 0.043 14.2 0.0 7.3 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX58729.1 - 1.3e-08 35.0 3.4 22 6.2 0.0 9.9 9 3 4 13 13 10 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX58729.1 - 1.5e-08 34.7 5.3 0.26 12.0 0.0 9.4 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX58729.1 - 9.4e-08 31.6 7.1 0.21 11.3 0.0 6.0 6 1 1 7 7 7 3 TPR repeat TPR_9 PF13371.6 ORX58729.1 - 4.1e-06 26.8 0.0 0.051 13.7 0.0 5.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX58729.1 - 9.1e-05 22.2 6.8 0.57 10.1 0.0 6.2 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX58729.1 - 0.0002 21.6 2.2 0.12 12.7 1.2 4.4 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX58729.1 - 0.0006 20.0 3.3 0.5 10.6 0.0 5.1 6 1 1 7 7 6 1 Anaphase-promoting complex, cyclosome, subunit 3 Vps39_1 PF10366.9 ORX58729.1 - 0.0064 16.8 2.5 2.5 8.4 0.2 3.1 2 0 0 2 2 2 2 Vacuolar sorting protein 39 domain 1 DUF4919 PF16266.5 ORX58729.1 - 0.0079 16.2 0.4 1.3 8.9 0.1 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4919) TPR_5 PF12688.7 ORX58729.1 - 0.018 15.3 0.0 0.26 11.5 0.0 3.0 3 1 0 3 3 3 0 Tetratrico peptide repeat AhpC-TSA PF00578.21 ORX58730.1 - 1.8e-39 134.5 0.0 3.1e-39 133.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX58730.1 - 5.7e-14 52.1 0.0 8.1e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ORX58730.1 - 2.4e-12 46.5 0.0 4.7e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin UMP1 PF05348.11 ORX58731.1 - 7.5e-42 142.3 0.6 8.9e-42 142.1 0.6 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 CPSase_L_D2 PF02786.17 ORX58732.1 - 4.8e-65 219.0 0.0 9e-65 218.1 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ORX58732.1 - 2.4e-44 150.4 0.0 5.4e-44 149.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX58732.1 - 1.2e-36 125.1 0.0 2.6e-36 124.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ORX58732.1 - 2.5e-07 30.4 0.1 8.5e-07 28.7 0.0 2.0 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX58732.1 - 4.3e-07 29.7 0.0 8.6e-07 28.7 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX58732.1 - 3.1e-06 26.9 0.0 7.2e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 ORX58732.1 - 0.04 13.2 0.0 0.21 10.8 0.0 1.9 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp SGS PF05002.15 ORX58733.1 - 3.6e-34 116.7 1.5 9.1e-34 115.4 1.5 1.7 1 0 0 1 1 1 1 SGS domain CS PF04969.16 ORX58733.1 - 3.4e-15 56.8 0.1 5.8e-15 56.1 0.1 1.4 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 ORX58733.1 - 1e-12 47.1 7.0 0.00092 19.2 0.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX58733.1 - 8.1e-11 41.3 6.6 0.008 16.0 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX58733.1 - 2.8e-08 33.9 6.7 9.9e-07 29.0 1.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX58733.1 - 2.6e-06 27.8 3.9 0.00015 22.2 1.5 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX58733.1 - 3.2e-06 26.9 3.4 0.051 13.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX58733.1 - 5.4e-06 27.0 3.6 0.044 14.4 0.5 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX58733.1 - 0.00018 21.7 2.1 0.00081 19.6 1.9 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 ORX58733.1 - 0.0007 20.0 2.4 0.024 15.3 0.2 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX58733.1 - 0.0012 19.5 7.7 0.29 12.1 0.1 3.2 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ORX58733.1 - 0.0024 17.5 0.2 0.084 12.6 0.0 2.7 2 1 0 2 2 2 1 TPR repeat TPR_7 PF13176.6 ORX58733.1 - 0.0042 17.0 4.0 1.3 9.2 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX58733.1 - 0.0095 16.1 1.2 2.6 8.2 0.4 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ORX58733.1 - 0.023 14.6 4.7 12 6.0 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat WYL PF13280.6 ORX58733.1 - 0.05 13.6 0.0 0.092 12.8 0.0 1.4 1 0 0 1 1 1 0 WYL domain NuiA PF07924.11 ORX58733.1 - 0.057 13.8 0.1 0.17 12.2 0.1 1.8 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein HTH_47 PF16221.5 ORX58733.1 - 0.1 12.2 0.1 0.31 10.6 0.0 1.8 2 0 0 2 2 2 0 winged helix-turn-helix DUF2057 PF09829.9 ORX58733.1 - 0.43 10.7 8.5 0.11 12.7 0.4 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) TPR_6 PF13174.6 ORX58733.1 - 3.3 8.5 4.7 8.1 7.3 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Sbt_1 PF05982.12 ORX58734.1 - 0.17 11.1 0.0 0.19 10.9 0.0 1.2 1 0 0 1 1 1 0 Na+-dependent bicarbonate transporter superfamily F-box PF00646.33 ORX58735.1 - 0.00017 21.4 3.4 0.00024 20.9 1.7 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX58735.1 - 0.00086 19.2 2.5 0.00086 19.2 2.5 2.4 3 0 0 3 3 3 1 F-box-like TilS PF09179.11 ORX58736.1 - 0.2 12.2 2.4 0.31 11.6 0.9 2.1 1 1 1 2 2 2 0 TilS substrate binding domain F-box-like PF12937.7 ORX58738.1 - 0.00024 20.9 0.2 0.00048 19.9 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX58738.1 - 0.0038 17.1 0.5 0.021 14.7 0.0 2.5 3 0 0 3 3 3 1 F-box domain DDE_3 PF13358.6 ORX58739.1 - 0.00044 20.0 0.3 0.00068 19.4 0.1 1.4 2 0 0 2 2 2 1 DDE superfamily endonuclease ocr PF08684.10 ORX58739.1 - 0.0016 18.8 0.0 0.0017 18.7 0.0 1.1 1 0 0 1 1 1 1 DNA mimic ocr DDE_3 PF13358.6 ORX58740.1 - 0.00014 21.6 0.0 0.00027 20.7 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease LZ_Tnp_IS481 PF13011.6 ORX58740.1 - 0.0036 17.8 0.0 0.0074 16.8 0.0 1.5 1 0 0 1 1 1 1 leucine-zipper of insertion element IS481 HTH_23 PF13384.6 ORX58740.1 - 0.0042 16.8 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_Tnp_Tc3_2 PF01498.18 ORX58740.1 - 0.048 13.9 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Transposase HTH_Tnp_IS630 PF01710.16 ORX58740.1 - 0.049 13.7 0.1 0.13 12.3 0.1 1.8 1 1 0 1 1 1 0 Transposase HTH_32 PF13565.6 ORX58740.1 - 0.061 14.0 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Herpes_US12 PF05363.12 ORX58740.1 - 0.099 13.4 0.0 0.21 12.3 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus US12 family DUF746 PF05344.11 ORX58740.1 - 0.14 12.0 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF746) F-box-like PF12937.7 ORX58741.1 - 0.0018 18.1 0.9 0.0049 16.7 0.9 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX58741.1 - 0.011 15.6 0.4 0.036 13.9 0.4 2.0 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 ORX58742.1 - 6e-05 22.8 0.5 0.00042 20.2 0.1 2.5 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX58742.1 - 0.00066 19.5 1.0 0.0043 16.9 0.0 2.9 3 0 0 3 3 3 1 F-box domain MH2 PF03166.14 ORX58742.1 - 0.12 12.6 0.0 0.45 10.7 0.0 2.0 2 0 0 2 2 2 0 MH2 domain LRR_6 PF13516.6 ORX58743.1 - 0.93 9.7 5.6 1.2e+02 3.1 0.5 4.9 5 0 0 5 5 5 0 Leucine Rich repeat E1-E2_ATPase PF00122.20 ORX58744.1 - 4.5e-50 169.7 2.0 4.5e-50 169.7 2.0 2.9 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX58744.1 - 1.9e-45 154.8 7.0 1.9e-45 154.8 7.0 2.6 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX58744.1 - 4.6e-22 79.3 2.2 3.2e-18 66.8 0.6 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX58744.1 - 5.7e-21 74.0 1.1 1.2e-20 72.9 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX58744.1 - 3e-20 72.1 0.0 5.9e-20 71.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX58744.1 - 1.2e-08 35.0 2.0 3.6e-07 30.2 1.8 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX58744.1 - 8.9e-06 26.2 0.0 2.2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase LapA_dom PF06305.11 ORX58744.1 - 0.46 10.3 1.8 2.8 7.8 1.8 2.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain HEAT_EZ PF13513.6 ORX58745.1 - 2.3e-20 72.7 10.0 4.6e-08 33.4 0.0 8.6 10 1 1 11 11 10 4 HEAT-like repeat HEAT_2 PF13646.6 ORX58745.1 - 1.6e-13 50.8 0.0 0.001 19.4 0.0 6.0 5 1 0 6 6 6 3 HEAT repeats HEAT PF02985.22 ORX58745.1 - 4.5e-11 42.0 10.3 0.0015 18.6 0.0 10.0 11 0 0 11 11 10 1 HEAT repeat Cnd1 PF12717.7 ORX58745.1 - 6.2e-08 32.8 0.3 0.19 11.8 0.0 4.9 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 ORX58745.1 - 1.2e-06 28.3 0.0 2.8e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 ORX58745.1 - 7e-06 26.6 0.0 0.22 12.1 0.0 4.1 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region DUF3731 PF12531.8 ORX58745.1 - 0.0032 17.3 0.1 8.5 6.1 0.0 3.2 3 0 0 3 3 3 1 DNA-K related protein CLASP_N PF12348.8 ORX58745.1 - 0.0042 16.7 0.1 9.8 5.7 0.0 3.9 3 1 1 4 4 4 2 CLASP N terminal MMS19_C PF12460.8 ORX58745.1 - 0.005 16.0 1.6 2 7.4 0.1 3.5 3 0 0 3 3 3 1 RNAPII transcription regulator C-terminal ParcG PF10274.9 ORX58745.1 - 0.0083 16.3 0.1 1.5 8.9 0.0 3.7 4 0 0 4 4 4 1 Parkin co-regulated protein Arm PF00514.23 ORX58745.1 - 0.028 14.5 9.8 3.6 7.8 0.0 6.8 9 0 0 9 9 9 0 Armadillo/beta-catenin-like repeat Stealth_CR2 PF11380.8 ORX58745.1 - 0.034 14.3 0.3 0.11 12.7 0.0 2.0 2 0 0 2 2 2 0 Stealth protein CR2, conserved region 2 RasGEF_N_2 PF14663.6 ORX58745.1 - 0.04 14.3 1.2 3.1 8.2 0.0 3.8 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain muHD PF10291.9 ORX58746.1 - 5.4e-17 62.1 0.0 8.8e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain FCH PF00611.23 ORX58746.1 - 1.2e-10 41.5 0.3 1.2e-10 41.5 0.3 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain TAP42 PF04177.12 ORX58746.1 - 0.0016 17.6 0.4 0.0016 17.6 0.4 1.7 2 0 0 2 2 2 1 TAP42-like family DUF4355 PF14265.6 ORX58746.1 - 0.024 14.9 4.9 0.046 14.0 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Hrs_helical PF12210.8 ORX58746.1 - 0.042 14.4 1.0 0.042 14.4 1.0 2.2 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate OmpH PF03938.14 ORX58746.1 - 0.28 11.5 4.0 0.6 10.5 4.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Seryl_tRNA_N PF02403.22 ORX58746.1 - 0.46 10.7 3.6 1.3 9.3 3.6 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 ORX58746.1 - 5.5 7.0 6.0 3.8 7.6 0.3 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Anoctamin PF04547.12 ORX58748.1 - 4e-105 352.3 19.3 4.7e-105 352.0 19.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel F-box-like PF12937.7 ORX58749.1 - 1.3e-07 31.4 1.5 1.3e-07 31.4 1.5 2.1 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX58749.1 - 1e-06 28.4 2.1 1.5e-06 27.9 0.4 2.3 2 0 0 2 2 2 1 F-box domain Aldolase_II PF00596.21 ORX58750.1 - 1.3e-48 165.4 0.0 1.6e-48 165.2 0.0 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain Ada3 PF10198.9 ORX58751.1 - 9.7e-32 109.9 5.5 9.7e-32 109.9 5.5 1.9 2 0 0 2 2 2 1 Histone acetyltransferases subunit 3 Cgr1 PF03879.14 ORX58752.1 - 1.5e-24 86.5 36.4 1.8e-24 86.2 36.4 1.0 1 0 0 1 1 1 1 Cgr1 family PBP_sp32 PF07222.12 ORX58752.1 - 0.5 9.8 6.8 0.59 9.5 6.8 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4404 PF14357.6 ORX58752.1 - 0.79 10.4 7.5 1.5 9.5 7.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) AAA_11 PF13086.6 ORX58752.1 - 9.8 5.9 15.7 11 5.7 15.7 1.1 1 0 0 1 1 1 0 AAA domain HLH PF00010.26 ORX58753.1 - 4e-12 45.9 2.2 7.6e-12 45.0 2.2 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain YabA PF06156.13 ORX58753.1 - 0.015 15.9 2.5 0.015 15.9 2.5 1.9 1 1 1 2 2 2 0 Initiation control protein YabA HSP90 PF00183.18 ORX58753.1 - 0.018 14.0 0.9 0.022 13.7 0.9 1.1 1 0 0 1 1 1 0 Hsp90 protein Torus PF16131.5 ORX58754.1 - 3.9e-32 111.2 0.8 7.8e-32 110.2 0.8 1.5 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 ORX58754.1 - 1.5e-09 37.5 0.0 2.7e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 ORX58754.1 - 0.0052 16.8 0.5 0.0087 16.1 0.5 1.4 1 0 0 1 1 1 1 Zinc finger domain Nup35_RRM_2 PF14605.6 ORX58754.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_4 PF18044.1 ORX58754.1 - 0.29 11.0 1.4 0.5 10.2 1.4 1.3 1 0 0 1 1 1 0 CCCH-type zinc finger PPTA PF01239.22 ORX58757.1 - 9.1e-36 120.6 14.3 2.4e-09 36.6 0.1 5.5 6 0 0 6 6 6 4 Protein prenyltransferase alpha subunit repeat PSCyt2 PF07583.11 ORX58757.1 - 1.9 8.4 9.0 15 5.4 4.1 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1549) Thioredoxin_7 PF13899.6 ORX58758.1 - 6.5e-16 58.3 0.0 1.7e-15 56.9 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like UBA_4 PF14555.6 ORX58758.1 - 2.6e-12 46.3 0.1 2.6e-12 46.3 0.1 1.9 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.20 ORX58758.1 - 6.1e-11 42.4 0.6 1.9e-10 40.8 0.3 2.0 2 0 0 2 2 2 1 UBX domain UIM PF02809.20 ORX58758.1 - 0.052 13.5 0.3 0.052 13.5 0.3 2.5 2 0 0 2 2 2 0 Ubiquitin interaction motif Motile_Sperm PF00635.26 ORX58759.1 - 1.2e-25 89.4 0.2 2.3e-25 88.5 0.2 1.5 1 0 0 1 1 1 1 MSP (Major sperm protein) domain DUF4515 PF14988.6 ORX58759.1 - 0.0088 15.9 0.2 0.014 15.3 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4515) ASH PF15780.5 ORX58759.1 - 0.035 14.3 2.4 0.044 14.0 0.4 2.1 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin fn3_6 PF17766.1 ORX58759.1 - 0.056 13.6 0.7 3.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Fibronectin type-III domain DUF3385 PF11865.8 ORX58759.1 - 0.079 12.9 0.1 0.97 9.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) Lectin_N PF03954.14 ORX58759.1 - 0.085 12.6 0.6 0.17 11.6 0.6 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain HBM PF16591.5 ORX58759.1 - 0.46 9.9 2.8 0.2 11.1 0.3 1.6 2 0 0 2 2 2 0 Helical bimodular sensor domain tRNA_Me_trans PF03054.16 ORX58760.1 - 2.3e-116 388.5 0.0 2.6e-116 388.3 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 ORX58760.1 - 4e-05 23.3 0.0 0.00083 19.0 0.0 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) NAD_synthase PF02540.17 ORX58760.1 - 0.00029 20.0 0.0 0.0014 17.8 0.0 1.9 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 ORX58760.1 - 0.006 16.1 0.0 0.013 15.0 0.0 1.6 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 ORX58760.1 - 0.048 13.3 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase ATP_bind_3 PF01171.20 ORX58760.1 - 0.056 13.2 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 PP-loop family Pkinase PF00069.25 ORX58761.1 - 8.2e-50 169.6 0.0 1.2e-49 169.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58761.1 - 3.4e-21 75.7 0.0 4.8e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX58761.1 - 6.4e-06 26.3 0.1 1.5e-05 25.0 0.1 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX58761.1 - 0.00057 18.9 0.3 0.00057 18.9 0.3 1.7 2 1 0 2 2 2 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ORX58761.1 - 0.079 12.0 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Choline_kinase PF01633.20 ORX58761.1 - 0.16 11.6 0.2 0.28 10.7 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase SAP25 PF15476.6 ORX58761.1 - 4 7.0 10.7 0.32 10.6 5.7 1.8 2 0 0 2 2 2 0 Histone deacetylase complex subunit SAP25 RSN1_7TM PF02714.15 ORX58762.1 - 1.2e-59 201.9 26.7 2e-59 201.2 26.7 1.3 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ORX58762.1 - 6.4e-20 72.1 0.0 1.9e-19 70.5 0.0 1.8 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ORX58762.1 - 2.2e-06 27.5 2.1 2.2e-06 27.5 2.1 3.3 4 1 0 4 4 4 1 Late exocytosis, associated with Golgi transport HSP90 PF00183.18 ORX58764.1 - 2.1e-180 601.0 8.2 2.9e-180 600.6 8.2 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ORX58764.1 - 1.3e-11 45.0 0.1 3.2e-11 43.7 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX58764.1 - 1.5e-10 41.1 0.1 4.7e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FmdE PF02663.14 ORX58764.1 - 0.32 11.0 2.0 20 5.2 0.1 3.4 3 0 0 3 3 3 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon FeoB_Cyto PF17910.1 ORX58764.1 - 5.8 7.5 8.3 1.1 9.9 0.0 3.3 3 0 0 3 3 3 0 FeoB cytosolic helical domain MFS_1 PF07690.16 ORX58765.1 - 2.9e-36 125.1 69.2 5.1e-27 94.7 41.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX58765.1 - 3.5e-06 26.1 37.7 6.2e-05 22.0 36.6 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter DUF5527 PF17665.1 ORX58765.1 - 0.35 10.4 3.2 0.18 11.3 0.4 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5527) DUF3341 PF11821.8 ORX58765.1 - 3.5 7.2 9.5 18 4.9 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3341) DUF1959 PF09218.10 ORX58766.1 - 0.0093 16.1 0.0 0.033 14.3 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1959) Metallophos PF00149.28 ORX58767.1 - 6.6e-40 137.8 0.0 8.7e-40 137.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX58767.1 - 7.1e-24 84.0 3.5 9.7e-23 80.4 1.1 2.3 2 0 0 2 2 2 2 Serine-threonine protein phosphatase N-terminal domain F-box PF00646.33 ORX58768.1 - 0.00031 20.6 1.2 0.00031 20.6 1.2 2.4 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX58768.1 - 0.0019 18.0 1.0 0.0058 16.5 1.0 1.9 1 0 0 1 1 1 1 F-box-like Syja_N PF02383.18 ORX58769.1 - 1.2e-79 268.0 0.2 2.1e-79 267.2 0.2 1.4 1 0 0 1 1 1 1 SacI homology domain Syja_N PF02383.18 ORX58770.1 - 1.4e-81 274.4 0.0 2e-81 273.8 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain DUF1772 PF08592.11 ORX58770.1 - 0.12 12.7 0.7 0.23 11.8 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) CAP_N PF01213.19 ORX58770.1 - 0.26 10.7 0.5 0.56 9.6 0.5 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Phosphodiest PF01663.22 ORX58772.1 - 5.9e-84 282.7 1.3 6.8e-84 282.5 1.3 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX58772.1 - 7.3e-05 22.3 0.0 0.0046 16.4 0.0 2.2 2 0 0 2 2 2 2 Sulfatase LuxC PF05893.14 ORX58772.1 - 0.14 11.2 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) SLC3A2_N PF16028.5 ORX58773.1 - 0.019 14.5 0.7 11 5.6 0.0 2.5 2 0 0 2 2 2 0 Solute carrier family 3 member 2 N-terminus CCDC-167 PF15188.6 ORX58773.1 - 0.058 13.7 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 HEAT_EZ PF13513.6 ORX58774.1 - 4.3e-23 81.4 16.6 5e-09 36.5 0.0 8.6 9 1 0 9 9 9 3 HEAT-like repeat HEAT_2 PF13646.6 ORX58774.1 - 7.4e-18 64.7 0.6 0.0012 19.2 0.0 6.1 4 1 2 6 6 6 4 HEAT repeats HEAT PF02985.22 ORX58774.1 - 4.7e-17 60.6 14.1 0.61 10.5 0.0 10.5 11 0 0 11 11 10 5 HEAT repeat Arm PF00514.23 ORX58774.1 - 2.9e-10 39.8 11.6 0.1 12.7 0.1 7.5 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat IBN_N PF03810.19 ORX58774.1 - 2.4e-08 33.7 0.0 1.5e-07 31.2 0.0 2.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cnd1 PF12717.7 ORX58774.1 - 9.4e-08 32.3 0.0 0.075 13.1 0.0 4.2 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ORX58774.1 - 2.1e-05 24.2 0.0 9.4 5.7 0.0 4.7 4 1 1 5 5 5 2 CLASP N terminal Vac14_Fab1_bd PF12755.7 ORX58774.1 - 5.7e-05 23.6 0.0 0.2 12.3 0.0 4.9 3 1 1 5 5 5 1 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 ORX58774.1 - 0.013 15.0 0.2 6.5 6.2 0.0 2.7 2 0 0 2 2 2 0 Tti2 family Urb2 PF10441.9 ORX58774.1 - 0.029 14.3 0.1 23 4.8 0.0 3.6 2 1 0 3 3 3 0 Urb2/Npa2 family UME PF08064.13 ORX58774.1 - 0.057 13.3 0.1 0.72 9.8 0.0 2.9 3 0 0 3 3 3 0 UME (NUC010) domain MMS19_C PF12460.8 ORX58774.1 - 0.35 9.9 8.1 4.4 6.3 0.1 4.7 5 1 1 6 6 6 0 RNAPII transcription regulator C-terminal Na_Ca_ex PF01699.24 ORX58775.1 - 9.6e-35 119.8 44.0 9.3e-19 67.9 15.0 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein ATP-synt_8 PF00895.20 ORX58775.1 - 0.048 14.1 0.5 0.048 14.1 0.5 2.5 2 1 0 2 2 2 0 ATP synthase protein 8 DUF3098 PF11297.8 ORX58775.1 - 0.2 11.3 4.5 0.83 9.3 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3098) I-set PF07679.16 ORX58777.1 - 1.8e-05 24.7 0.0 1.9 8.6 0.0 5.3 6 0 0 6 6 6 2 Immunoglobulin I-set domain Ig_3 PF13927.6 ORX58777.1 - 0.0061 17.1 0.1 3.8 8.2 0.0 4.7 5 0 0 5 5 5 1 Immunoglobulin domain Ribosomal_L14e PF01929.17 ORX58778.1 - 2e-29 101.9 2.6 2.9e-29 101.3 2.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 ORX58778.1 - 0.0018 18.2 0.1 0.003 17.4 0.1 1.4 1 0 0 1 1 1 1 KOW motif Chitin_synth_1 PF01644.17 ORX58779.1 - 4e-77 257.8 0.0 5.9e-77 257.2 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX58779.1 - 8.3e-29 99.4 0.9 1.9e-28 98.2 0.3 1.9 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX58779.1 - 8.7e-19 67.5 1.0 2e-16 59.7 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX58779.1 - 3.5e-06 27.1 4.5 3.5e-06 27.1 4.5 3.0 2 1 1 3 3 3 1 Glycosyl transferase family group 2 CitMHS PF03600.16 ORX58779.1 - 0.017 14.4 0.7 0.025 13.8 0.7 1.3 1 0 0 1 1 1 0 Citrate transporter GYR PF02756.14 ORX58779.1 - 0.59 9.9 5.7 1.6 8.5 5.7 1.8 1 0 0 1 1 1 0 GYR motif Cullin_binding PF03556.15 ORX58780.1 - 5.3e-27 94.6 1.2 5.3e-27 94.6 1.2 2.0 1 1 1 2 2 2 1 Cullin binding Lactamase_B_4 PF13691.6 ORX58780.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 tRNase Z endonuclease Mito_carr PF00153.27 ORX58781.1 - 3.1e-62 206.5 3.4 2.5e-20 72.2 0.0 3.9 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX58781.1 - 0.026 13.7 0.0 0.082 12.0 0.0 1.7 2 0 0 2 2 2 0 Gammaproteobacterial serine protease Chromo PF00385.24 ORX58783.1 - 2.5e-06 27.3 0.2 4.6e-06 26.4 0.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 ORX58783.1 - 0.06 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Chromo shadow domain UQ_con PF00179.26 ORX58785.1 - 7.3e-48 161.8 0.0 8.2e-48 161.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX58785.1 - 8.8e-07 28.7 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ORX58785.1 - 0.011 16.0 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain DUF4245 PF14030.6 ORX58788.1 - 0.087 12.8 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) Complex1_51K PF01512.17 ORX58789.1 - 2.1e-49 167.3 0.0 3e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ORX58789.1 - 2e-31 107.9 0.0 4.1e-31 106.9 0.0 1.6 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ORX58789.1 - 6.2e-08 32.4 0.0 1.3e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 SLBB domain Ammonium_transp PF00909.21 ORX58790.1 - 3.6e-119 398.0 25.5 4.1e-119 397.8 25.5 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Phage_holin_3_1 PF05106.12 ORX58790.1 - 0.26 11.8 6.5 0.14 12.6 0.7 2.8 2 1 0 2 2 2 0 Phage holin family (Lysis protein S) Apt1 PF10351.9 ORX58791.1 - 4.2e-65 220.5 0.0 4.2e-65 220.5 0.0 3.4 3 1 0 3 3 3 1 Golgi-body localisation protein domain Fmp27_WPPW PF10359.9 ORX58791.1 - 3e-44 151.7 2.4 1.7e-37 129.4 2.0 2.5 2 0 0 2 2 2 2 RNA pol II promoter Fmp27 protein domain Fmp27_GFWDK PF10347.9 ORX58791.1 - 1.3e-26 93.6 0.0 3.6e-25 88.9 0.0 2.6 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain APG17 PF04108.12 ORX58791.1 - 0.011 14.9 2.6 0.021 14.0 2.6 1.4 1 0 0 1 1 1 0 Autophagy protein Apg17 Homeodomain PF00046.29 ORX58792.1 - 1.1e-19 70.0 1.0 2.2e-19 69.0 1.0 1.6 1 0 0 1 1 1 1 Homeodomain DEAD PF00270.29 ORX58793.1 - 6.6e-18 65.1 0.0 2.1e-17 63.5 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX58793.1 - 1.5e-12 47.8 0.0 7.1e-12 45.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ORX58793.1 - 7.4e-10 39.4 0.4 4.4e-09 36.9 0.2 2.4 2 0 0 2 2 2 1 RecQ zinc-binding ResIII PF04851.15 ORX58793.1 - 2.5e-05 24.4 0.0 0.00011 22.2 0.0 2.2 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF4407 PF14362.6 ORX58793.1 - 0.00085 18.8 1.1 0.0012 18.2 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Spc24 PF08286.11 ORX58793.1 - 0.0066 16.7 1.4 0.013 15.7 1.4 1.5 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 RQC PF09382.10 ORX58793.1 - 0.097 12.5 0.5 1.1 9.1 0.4 2.7 2 1 0 2 2 2 0 RQC domain TMF_TATA_bd PF12325.8 ORX58793.1 - 0.15 12.2 2.5 0.3 11.3 2.5 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Osmo_CC PF08946.10 ORX58793.1 - 0.34 11.2 4.2 0.28 11.5 2.0 2.0 2 0 0 2 2 2 0 Osmosensory transporter coiled coil YabA PF06156.13 ORX58793.1 - 0.42 11.3 2.5 1.3 9.7 2.5 1.9 1 0 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 ORX58793.1 - 0.44 10.9 5.2 1 9.8 5.2 1.7 1 0 0 1 1 1 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 ORX58793.1 - 0.86 9.9 6.7 2 8.7 6.7 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain GrpE PF01025.19 ORX58793.1 - 1.9 8.1 5.6 3.6 7.2 5.6 1.4 1 0 0 1 1 1 0 GrpE TolA_bind_tri PF16331.5 ORX58793.1 - 2 8.6 13.1 38 4.4 13.4 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation FlxA PF14282.6 ORX58793.1 - 3.7 7.6 17.4 8.8 6.4 17.4 1.6 1 0 0 1 1 1 0 FlxA-like protein DUF2802 PF10975.8 ORX58793.1 - 4.2 7.6 6.8 13 6.0 6.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2802) Leu_zip PF15294.6 ORX58794.1 - 0.013 15.0 27.1 0.02 14.4 8.1 2.1 1 1 1 2 2 2 0 Leucine zipper DegT_DnrJ_EryC1 PF01041.17 ORX58794.1 - 1.9 7.7 11.2 1.8 7.8 2.7 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Laminin_II PF06009.12 ORX58794.1 - 3 7.8 12.8 0.32 11.0 4.2 2.5 1 1 1 2 2 2 0 Laminin Domain II ALMT PF11744.8 ORX58794.1 - 9.1 5.0 14.3 13 4.5 14.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC24_OB2 PF17245.2 ORX58795.1 - 0.062 13.9 0.3 0.094 13.3 0.3 1.3 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 2 HEAT PF02985.22 ORX58796.1 - 0.019 15.2 0.3 21 5.7 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat Ribosomal_L34e PF01199.18 ORX58797.1 - 1.2e-43 147.3 6.6 1.6e-43 146.9 6.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L34e ADK_lid PF05191.14 ORX58797.1 - 0.034 14.1 0.5 0.094 12.7 0.5 1.8 1 0 0 1 1 1 0 Adenylate kinase, active site lid PDGF PF00341.17 ORX58797.1 - 0.056 13.7 1.3 1.1 9.6 0.1 2.1 1 1 1 2 2 2 0 PDGF/VEGF domain CRAL_TRIO PF00650.20 ORX58798.1 - 4.6e-35 120.7 0.1 5.9e-35 120.3 0.1 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ORX58798.1 - 0.029 14.5 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Pro_dh-DNA_bdg PF14850.6 ORX58798.1 - 0.079 13.5 0.0 0.32 11.5 0.0 2.0 1 1 1 2 2 2 0 DNA-binding domain of Proline dehydrogenase DED PF01335.21 ORX58798.1 - 0.081 13.2 0.1 0.18 12.1 0.1 1.5 1 0 0 1 1 1 0 Death effector domain STAG PF08514.11 ORX58799.1 - 0.087 12.7 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 STAG domain HNH_4 PF13395.6 ORX58799.1 - 0.14 12.1 0.1 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 HNH endonuclease DDOST_48kD PF03345.14 ORX58800.1 - 1.9e-121 405.8 0.1 2.3e-121 405.5 0.1 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta AstA PF04958.12 ORX58800.1 - 0.03 12.9 0.0 0.069 11.7 0.0 1.5 2 0 0 2 2 2 0 Arginine N-succinyltransferase beta subunit AA_permease PF00324.21 ORX58800.1 - 0.19 10.3 1.2 1.2 7.6 0.1 2.0 2 0 0 2 2 2 0 Amino acid permease MFS_1 PF07690.16 ORX58801.1 - 4.2e-08 32.5 26.9 6.6e-05 22.0 14.7 2.8 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF4396 PF14342.6 ORX58801.1 - 0.0012 19.2 4.8 0.0012 19.2 4.8 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4396) SpoIIIAC PF06686.11 ORX58801.1 - 0.27 11.4 4.4 0.41 10.9 0.3 2.6 2 0 0 2 2 2 0 Stage III sporulation protein AC/AD protein family Phosducin PF02114.16 ORX58802.1 - 1.4e-10 40.6 0.5 1.7e-10 40.3 0.5 1.0 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 ORX58802.1 - 6e-05 23.0 0.0 0.00011 22.1 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Peptidase_M48 PF01435.18 ORX58803.1 - 1.8e-18 67.0 0.1 2.7e-18 66.5 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M48 MRC1 PF09444.10 ORX58806.1 - 8.8e-26 91.2 8.3 8.8e-26 91.2 8.3 7.4 7 1 2 9 9 9 2 MRC1-like domain RRM_1 PF00076.22 ORX58807.1 - 3e-16 59.0 0.0 4.9e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) UPF0203 PF05254.12 ORX58808.1 - 5.3e-26 90.7 0.9 6.2e-26 90.4 0.9 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 ORX58808.1 - 0.013 15.7 0.7 0.021 15.0 0.7 1.4 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein COX17 PF05051.13 ORX58808.1 - 0.09 13.1 0.7 0.09 13.1 0.7 1.9 2 1 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF5339 PF17274.2 ORX58808.1 - 0.15 13.0 0.6 0.97 10.3 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5339) Cmc1 PF08583.10 ORX58808.1 - 0.2 11.7 2.7 6.1 6.9 0.1 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like VraX PF17412.2 ORX58808.1 - 0.27 10.9 1.0 14 5.5 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function zf-CCCH PF00642.24 ORX58809.1 - 0.00073 19.4 0.3 0.00073 19.4 0.3 4.7 5 0 0 5 5 5 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ORX58809.1 - 0.0073 16.5 8.4 0.15 12.3 1.3 2.4 1 1 1 2 2 2 2 Zinc-finger containing family zf-C3H1 PF10650.9 ORX58809.1 - 0.17 11.7 10.3 1.2 9.0 0.1 4.2 4 1 0 4 4 4 0 Putative zinc-finger domain zf_CCCH_4 PF18345.1 ORX58809.1 - 7.4 6.8 24.5 0.4 10.8 1.9 5.7 4 2 0 4 4 4 0 Zinc finger domain Antifungal_prot PF11402.8 ORX58809.1 - 9.5 6.5 11.0 36 4.7 0.0 3.8 1 1 3 4 4 4 0 Antifungal protein IF4E PF01652.18 ORX58811.1 - 5e-40 136.9 0.2 7.1e-40 136.4 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Oxysterol_BP PF01237.18 ORX58812.1 - 9.8e-86 287.9 0.2 1.9e-78 263.9 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein SCP2 PF02036.17 ORX58813.1 - 2e-07 31.4 0.0 2.9e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 SCP-2 sterol transfer family Mid1 PF12929.7 ORX58814.1 - 1.3e-72 245.3 15.8 4.6e-72 243.5 15.8 1.7 1 1 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 ORX58814.1 - 5.9e-06 26.9 6.0 0.00076 20.1 1.7 2.8 2 0 0 2 2 2 2 Fz domain Glycos_transf_3 PF00591.21 ORX58815.1 - 3.5e-88 295.5 0.9 4.2e-88 295.2 0.9 1.1 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 ORX58815.1 - 0.00012 21.8 0.1 0.00037 20.3 0.0 1.9 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain ACP_syn_III PF08545.10 ORX58815.1 - 0.21 11.5 1.7 13 5.7 0.0 3.2 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Peptidase_M41 PF01434.18 ORX58816.1 - 4.6e-68 228.8 0.0 8.8e-68 227.9 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX58816.1 - 4.3e-43 146.9 0.0 1e-42 145.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) COX5A PF02284.16 ORX58816.1 - 5.2e-36 122.8 0.3 1.5e-35 121.3 0.1 1.9 2 0 0 2 2 2 1 Cytochrome c oxidase subunit Va AAA_lid_3 PF17862.1 ORX58816.1 - 3.7e-14 52.2 1.3 6.1e-14 51.6 0.2 2.0 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 ORX58816.1 - 2.2e-09 37.6 0.0 6.5e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 FtsH Extracellular AAA_16 PF13191.6 ORX58816.1 - 0.0022 18.4 0.6 0.068 13.6 0.1 2.9 2 1 0 3 3 3 1 AAA ATPase domain TIP49 PF06068.13 ORX58816.1 - 0.0037 16.5 0.1 0.0069 15.6 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 ORX58816.1 - 0.0038 17.2 0.2 0.043 13.8 0.0 2.9 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 ORX58816.1 - 0.019 14.7 0.0 0.04 13.7 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX58816.1 - 0.03 14.6 0.0 0.85 9.9 0.1 2.6 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX58816.1 - 0.088 12.5 0.4 0.24 11.1 0.0 2.0 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_17 PF13207.6 ORX58816.1 - 0.097 13.1 0.4 0.29 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ORX58816.1 - 0.098 12.0 0.3 0.56 9.5 0.2 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_2 PF07724.14 ORX58816.1 - 0.13 12.4 0.0 0.63 10.1 0.0 2.2 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) NTP_transferase PF00483.23 ORX58818.1 - 5.6e-53 180.1 0.0 7.4e-53 179.7 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ORX58818.1 - 5.4e-14 51.3 3.8 3.7e-11 42.3 2.4 3.5 2 1 0 2 2 2 1 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX58818.1 - 2.6e-09 37.6 0.0 3.8e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 ORX58818.1 - 0.00064 19.4 2.3 0.00064 19.4 2.3 3.5 4 1 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 ORX58818.1 - 0.061 11.4 0.1 0.088 10.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) IspD PF01128.19 ORX58818.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Pkinase PF00069.25 ORX58819.1 - 3.4e-68 229.9 0.0 4.1e-68 229.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58819.1 - 8.7e-37 126.8 0.0 1.1e-36 126.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX58819.1 - 1.7e-09 37.4 0.0 9.4e-09 35.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 ORX58819.1 - 0.0022 17.1 0.0 0.0033 16.5 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 APH PF01636.23 ORX58819.1 - 0.0035 17.3 0.0 0.0059 16.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX58819.1 - 0.0039 16.6 0.0 0.0067 15.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX58819.1 - 0.025 13.5 0.1 0.054 12.4 0.1 1.5 1 1 0 1 1 1 0 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 ORX58819.1 - 0.043 13.3 0.0 0.07 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ORX58819.1 - 0.054 12.3 0.0 0.083 11.6 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SBBP PF06739.11 ORX58819.1 - 0.088 12.8 1.4 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Beta-propeller repeat FTA2 PF13095.6 ORX58819.1 - 0.1 12.2 0.1 1.3 8.6 0.0 2.2 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DX PF01666.17 ORX58820.1 - 0.016 15.6 0.2 0.025 15.0 0.2 1.4 1 0 0 1 1 1 0 DX module CIA30 PF08547.12 ORX58821.1 - 1e-45 155.7 0.0 1.2e-45 155.4 0.0 1.0 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) SGBP_B_XBD PF18329.1 ORX58821.1 - 0.013 15.4 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain TBCA PF02970.16 ORX58822.1 - 4.3e-26 91.1 6.4 5.3e-26 90.8 6.4 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A OmdA PF13376.6 ORX58822.1 - 0.00088 19.2 0.4 0.014 15.4 0.1 2.4 3 0 0 3 3 3 1 Bacteriocin-protection, YdeI or OmpD-Associated SbcD_C PF12320.8 ORX58822.1 - 0.011 16.0 1.1 0.011 16.0 1.1 1.8 1 1 1 2 2 2 0 Type 5 capsule protein repressor C-terminal domain DUF4698 PF15769.5 ORX58822.1 - 0.016 14.3 1.0 0.019 14.1 1.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) ASL_C PF08328.11 ORX58822.1 - 0.024 14.7 1.2 0.033 14.3 1.2 1.3 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminal Vpu PF00558.19 ORX58822.1 - 0.024 14.4 4.7 0.048 13.4 0.3 2.2 1 1 1 2 2 2 0 Vpu protein DUF5113 PF17140.4 ORX58822.1 - 0.028 14.2 0.2 0.034 14.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) DUF5343 PF17278.2 ORX58822.1 - 0.043 13.9 1.1 0.071 13.2 0.7 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5343) Ribonuc_red_lgC PF02867.15 ORX58822.1 - 0.057 12.0 1.3 0.068 11.7 1.3 1.0 1 0 0 1 1 1 0 Ribonucleotide reductase, barrel domain DUF16 PF01519.16 ORX58822.1 - 0.13 12.8 3.8 0.063 13.8 1.8 1.5 2 0 0 2 2 2 0 Protein of unknown function DUF16 Chitin_synth_2 PF03142.15 ORX58823.1 - 1.6e-239 796.0 1.3 2.3e-239 795.4 1.3 1.2 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 ORX58823.1 - 1.5e-115 387.0 0.0 5.6e-108 361.9 0.0 2.1 2 0 0 2 2 2 2 Myosin head (motor domain) DEK_C PF08766.11 ORX58823.1 - 5.2e-17 61.5 0.0 7.1e-16 57.9 0.0 2.7 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 ORX58823.1 - 4.4e-13 49.6 2.1 4.4e-13 49.6 2.1 2.1 2 0 0 2 2 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX58823.1 - 7.7e-13 48.9 0.0 3.3e-12 46.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 ORX58823.1 - 3.7e-11 43.0 0.4 1.5e-06 28.2 0.0 2.8 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 ORX58823.1 - 7e-05 22.7 0.0 0.0052 16.6 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX58823.1 - 0.0017 17.9 0.0 0.0071 15.8 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferase family 21 AAA_16 PF13191.6 ORX58823.1 - 0.035 14.5 0.1 0.085 13.2 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 ORX58823.1 - 0.04 13.0 0.0 0.075 12.1 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ORX58823.1 - 0.048 13.9 0.1 0.15 12.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain Nefa_Nip30_N PF10187.9 ORX58824.1 - 5e-18 65.4 14.3 5e-18 65.4 14.3 1.6 2 0 0 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 DUF572 PF04502.13 ORX58824.1 - 0.00025 20.8 16.8 0.00031 20.5 16.8 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) PWI PF01480.17 ORX58825.1 - 1.5e-06 28.4 0.5 3.4e-06 27.3 0.0 1.9 2 0 0 2 2 2 1 PWI domain Nup35_RRM_2 PF14605.6 ORX58825.1 - 1.4e-05 25.0 0.0 0.0044 17.0 0.0 2.5 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_1 PF00076.22 ORX58825.1 - 5.2e-05 23.0 3.5 0.00031 20.5 0.2 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 ORX58825.1 - 0.0013 18.6 3.4 0.0028 17.5 3.4 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX58825.1 - 0.0025 17.8 2.9 0.0053 16.8 2.9 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_2 PF14608.6 ORX58825.1 - 0.89 10.1 4.0 1.6 9.3 4.0 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger DUF4518 PF15008.6 ORX58825.1 - 1.5 7.9 6.7 3.9 6.6 6.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) CorA PF01544.18 ORX58825.1 - 5.8 6.1 5.3 11 5.3 5.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein XPC-binding PF09280.11 ORX58825.1 - 6.7 6.5 13.7 0.097 12.4 5.5 2.2 2 0 0 2 2 2 0 XPC-binding domain Sin3a_C PF16879.5 ORX58826.1 - 3.4e-66 223.9 5.3 3.4e-66 223.9 5.3 3.3 4 0 0 4 4 4 1 C-terminal domain of Sin3a protein PAH PF02671.21 ORX58826.1 - 2.8e-45 152.2 9.1 6.7e-18 64.6 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ORX58826.1 - 7.2e-38 128.6 0.3 1.9e-37 127.3 0.3 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor DUF1077 PF06417.12 ORX58827.1 - 2.1e-47 160.0 1.2 2.5e-47 159.7 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Sm_multidrug_ex PF06695.11 ORX58827.1 - 0.04 14.6 0.2 0.061 14.0 0.2 1.2 1 0 0 1 1 1 0 Putative small multi-drug export protein Sds3 PF08598.11 ORX58829.1 - 1.1e-17 64.7 16.7 1.7e-17 64.2 16.7 1.2 1 0 0 1 1 1 1 Sds3-like DUF1090 PF06476.12 ORX58829.1 - 0.029 14.5 3.3 0.06 13.5 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Stathmin PF00836.19 ORX58829.1 - 0.069 13.1 8.9 0.14 12.1 1.6 2.5 2 0 0 2 2 2 0 Stathmin family LRR_4 PF12799.7 ORX58830.1 - 6.7e-34 115.4 65.0 4.6e-09 36.4 2.0 7.1 2 1 7 10 10 10 9 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX58830.1 - 1.6e-24 85.5 66.1 1.8e-07 30.8 3.3 6.5 1 1 8 9 9 9 8 Leucine rich repeat LRR_9 PF14580.6 ORX58830.1 - 1.6e-17 63.6 20.5 1.1e-08 34.8 5.3 3.8 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 ORX58830.1 - 9.4e-06 25.5 24.3 6.1 7.8 0.2 8.9 8 1 0 8 8 8 2 Leucine Rich Repeat Pallilysin PF18663.1 ORX58830.1 - 0.00046 20.2 3.7 0.11 12.4 0.2 2.4 2 0 0 2 2 2 2 Pallilysin beta barrel domain LRR_6 PF13516.6 ORX58830.1 - 0.013 15.4 22.7 1.8 8.8 0.3 7.7 10 0 0 10 10 10 0 Leucine Rich repeat MLD PF11647.8 ORX58830.1 - 1.9 8.9 6.5 6.7 7.1 0.0 3.8 2 1 2 4 4 4 0 Membrane Localization Domain ubiquitin PF00240.23 ORX58832.1 - 1.2e-134 438.2 21.8 3.6e-33 113.1 0.8 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 ORX58832.1 - 9.4e-61 201.6 22.5 1e-14 54.1 0.8 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX58832.1 - 8.1e-22 77.5 11.4 0.00069 20.0 0.2 5.8 4 4 0 4 4 4 4 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX58832.1 - 1.4e-14 54.2 2.5 0.11 12.6 0.0 5.0 4 4 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ORX58832.1 - 2.3e-14 53.5 10.0 0.032 14.6 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain TBK1_ULD PF18396.1 ORX58832.1 - 3.3e-14 52.6 4.3 0.08 12.9 0.0 4.2 4 0 0 4 4 4 4 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ORX58832.1 - 7.3e-13 49.0 1.7 0.34 11.5 0.0 4.2 1 1 1 4 4 4 4 DUF2407 ubiquitin-like domain Sde2_N_Ubi PF13019.6 ORX58832.1 - 1.2e-09 38.2 0.5 1.2 9.0 0.0 4.1 1 1 3 4 4 4 4 Silencing defective 2 N-terminal ubiquitin domain DUF3861 PF12977.7 ORX58832.1 - 2.5e-07 30.8 3.6 5.4 7.3 0.0 4.2 4 0 0 4 4 4 4 Domain of Unknown Function with PDB structure (DUF3861) Methyltrans_RNA PF04452.14 ORX58832.1 - 7.3e-06 25.5 0.6 2.4 7.4 0.0 3.3 3 0 0 3 3 3 3 RNA methyltransferase DUF2870 PF11069.8 ORX58832.1 - 7.9e-06 26.2 0.0 30 5.1 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2870) Big_7 PF17957.1 ORX58832.1 - 8.8e-06 26.4 0.1 36 5.2 0.0 4.2 4 0 0 4 4 4 0 Bacterial Ig domain Ubiquitin_4 PF18036.1 ORX58832.1 - 1.5e-05 25.0 24.8 25 5.0 0.0 7.9 8 0 0 8 8 8 0 Ubiquitin-like domain ACT_5 PF13710.6 ORX58832.1 - 1.9e-05 24.4 6.0 9 6.2 0.1 4.3 4 0 0 4 4 4 0 ACT domain DUF493 PF04359.14 ORX58832.1 - 4.5e-05 24.0 0.1 48 4.6 0.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF493) Big_3_3 PF13750.6 ORX58832.1 - 0.00014 21.6 0.0 34 4.0 0.0 4.1 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Raf1_HTH PF18579.1 ORX58832.1 - 0.0002 21.0 1.4 37 4.1 0.0 4.2 4 0 0 4 4 4 0 Rubisco accumulation factor 1 helix turn helix domain UDP-g_GGTase PF06427.11 ORX58832.1 - 0.00032 20.8 5.8 6.5 6.9 0.1 4.0 4 0 0 4 4 4 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 ORX58832.1 - 0.00045 19.7 0.0 23 4.3 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF1940 PF09155.10 ORX58832.1 - 0.00094 19.3 5.1 31 4.7 0.1 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1940) ACT_4 PF13291.6 ORX58832.1 - 0.0014 19.2 1.8 88 3.8 0.0 4.3 4 0 0 4 4 4 0 ACT domain ORF11CD3 PF10549.9 ORX58832.1 - 0.0048 17.0 0.0 91 3.3 0.0 4.5 4 0 0 4 4 4 0 ORF11CD3 domain Baculo_p48 PF04878.13 ORX58832.1 - 0.005 15.8 0.1 21 3.9 0.0 3.3 4 0 0 4 4 4 0 Baculovirus P48 protein FidL_like PF15941.5 ORX58832.1 - 0.0086 16.5 1.8 1.3e+02 3.1 0.0 4.4 4 0 0 4 4 4 0 FidL-like putative membrane protein CorA PF01544.18 ORX58832.1 - 0.035 13.4 0.3 1.1e+02 2.0 0.0 3.8 4 0 0 4 4 4 0 CorA-like Mg2+ transporter protein ProRS-C_2 PF09181.10 ORX58832.1 - 0.054 13.6 6.3 80 3.5 0.1 4.1 4 0 0 4 4 4 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 ORX58832.1 - 0.13 12.4 27.2 6.2 7.1 1.4 4.3 4 0 0 4 4 4 0 Tash protein PEST motif Myosin_N PF02736.19 ORX58832.1 - 0.18 11.7 5.5 1.1e+02 2.8 0.0 5.0 4 0 0 4 4 4 0 Myosin N-terminal SH3-like domain PI3K_p85B PF02192.16 ORX58832.1 - 2.3 8.0 9.6 96 2.8 0.1 4.2 4 0 0 4 4 4 0 PI3-kinase family, p85-binding domain FlgD_ig PF13860.6 ORX58832.1 - 2.6 8.0 8.7 1.3e+02 2.5 0.1 4.2 4 0 0 4 4 4 0 FlgD Ig-like domain Suf PF05843.14 ORX58833.1 - 7.4e-75 252.7 0.3 1.5e-71 241.8 0.0 5.5 5 2 0 5 5 5 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ORX58833.1 - 8.4e-07 29.3 4.8 0.025 15.4 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX58833.1 - 0.0021 18.5 4.1 0.024 15.2 0.4 4.0 5 1 1 6 6 4 2 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX58833.1 - 0.003 16.7 19.1 0.21 10.7 1.7 6.4 5 1 1 6 6 6 1 NRDE-2, necessary for RNA interference TPR_6 PF13174.6 ORX58833.1 - 0.025 15.2 0.2 0.69 10.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat HAT PF02184.16 ORX58833.1 - 0.03 14.3 0.1 0.11 12.5 0.0 2.0 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat Apolipoprotein PF01442.18 ORX58833.1 - 0.11 12.4 9.9 0.23 11.3 9.9 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Gp58 PF07902.11 ORX58833.1 - 0.13 10.5 1.2 0.19 10.0 1.2 1.2 1 0 0 1 1 1 0 gp58-like protein SLATT_4 PF18186.1 ORX58833.1 - 0.17 11.5 2.2 0.17 11.5 0.5 1.9 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 Fungal_TACC PF12709.7 ORX58833.1 - 0.7 10.4 4.5 5 7.6 1.3 3.0 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins PhoU PF01895.19 ORX58833.1 - 2.8 8.4 6.0 15 6.1 3.7 2.8 1 1 1 2 2 2 0 PhoU domain Mad3_BUB1_I PF08311.12 ORX58833.1 - 3.8 7.5 11.7 3.2 7.7 3.0 3.8 3 1 1 4 4 4 0 Mad3/BUB1 homology region 1 TPR_17 PF13431.6 ORX58833.1 - 4 8.0 7.8 21 5.8 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RhoGAP PF00620.27 ORX58834.1 - 1.5e-07 31.3 0.1 6.8e-07 29.2 0.1 2.0 1 1 0 1 1 1 1 RhoGAP domain Bax1-I PF01027.20 ORX58835.1 - 3.2e-48 164.3 30.2 3.7e-48 164.1 30.2 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 PH PF00169.29 ORX58836.1 - 4e-21 75.5 0.3 8.5e-21 74.4 0.3 1.5 1 0 0 1 1 1 1 PH domain SH3_9 PF14604.6 ORX58836.1 - 2.8e-14 52.7 0.2 8.8e-14 51.1 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX58836.1 - 4.4e-11 42.2 1.7 5e-11 42.0 0.3 1.9 2 0 0 2 2 2 1 SH3 domain PH_11 PF15413.6 ORX58836.1 - 5.5e-09 36.4 4.3 1.9e-06 28.2 4.3 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain SH3_2 PF07653.17 ORX58836.1 - 5.9e-07 29.1 0.1 1.3e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_2 PF07647.17 ORX58836.1 - 7.6e-06 25.9 0.2 1.4e-05 25.1 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 ORX58836.1 - 0.0012 19.1 0.7 0.0041 17.4 0.7 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain SAM_1 PF00536.30 ORX58836.1 - 0.018 15.5 0.0 0.032 14.7 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PH_3 PF14593.6 ORX58836.1 - 0.034 14.3 0.2 0.11 12.6 0.1 1.8 2 0 0 2 2 2 0 PH domain Kelch_4 PF13418.6 ORX58837.1 - 2.9e-14 52.8 14.7 0.00014 21.8 0.1 6.4 6 0 0 6 6 6 4 Galactose oxidase, central domain Kelch_2 PF07646.15 ORX58837.1 - 5.6e-05 23.0 17.6 1.1 9.3 0.2 6.8 5 2 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ORX58837.1 - 6.1e-05 22.5 21.4 0.24 11.0 0.1 6.5 7 0 0 7 7 7 4 Kelch motif Kelch_6 PF13964.6 ORX58837.1 - 0.00031 20.9 18.3 6 7.3 0.0 6.5 4 2 2 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ORX58837.1 - 0.00074 19.7 27.7 0.22 11.9 2.1 7.0 6 2 1 7 7 7 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX58837.1 - 0.00088 19.2 29.3 0.12 12.4 0.1 6.6 6 1 0 6 6 6 2 Kelch motif SKG6 PF08693.10 ORX58837.1 - 0.013 14.9 4.6 0.028 13.8 4.6 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Gram_pos_anchor PF00746.21 ORX58837.1 - 0.02 14.8 0.3 0.05 13.6 0.3 1.8 1 0 0 1 1 1 0 LPXTG cell wall anchor motif TraT PF05818.12 ORX58837.1 - 0.32 10.6 2.6 0.56 9.9 2.6 1.3 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein VSP PF03302.13 ORX58837.1 - 6.2 5.6 8.6 6.6 5.5 7.4 1.6 2 0 0 2 2 2 0 Giardia variant-specific surface protein SPRY PF00622.28 ORX58838.1 - 1.9e-18 66.7 0.0 2.9e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 SPRY domain Ribosomal_L4 PF00573.22 ORX58839.1 - 9.3e-38 129.8 1.7 1.7e-37 128.9 1.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ORX58839.1 - 6.6e-31 106.2 1.9 6.6e-31 106.2 1.9 2.2 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain BChl_A PF02327.17 ORX58839.1 - 0.13 11.0 0.1 0.25 10.1 0.1 1.4 1 0 0 1 1 1 0 Bacteriochlorophyll A protein Kinesin PF00225.23 ORX58840.1 - 1.8e-105 352.5 0.2 1.8e-105 352.5 0.2 4.2 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ORX58840.1 - 5.9e-22 78.2 0.1 2e-16 60.3 0.1 3.6 2 0 0 2 2 2 2 Microtubule binding Ribosomal_L20 PF00453.18 ORX58840.1 - 0.56 10.3 6.3 6.6 6.9 0.1 4.7 3 0 0 3 3 3 0 Ribosomal protein L20 YebO PF13974.6 ORX58840.1 - 1 9.5 0.0 1 9.5 0.0 8.7 11 1 1 12 12 12 0 YebO-like protein IKKbetaNEMObind PF12179.8 ORX58840.1 - 8 6.6 11.4 5.8 7.1 1.4 4.8 2 1 1 3 3 3 0 I-kappa-kinase-beta NEMO binding domain Homeobox_KN PF05920.11 ORX58841.1 - 1.4e-19 69.7 0.4 3.3e-19 68.5 0.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ORX58841.1 - 3.5e-09 36.4 0.5 6.8e-09 35.4 0.5 1.5 1 0 0 1 1 1 1 Homeodomain Sec8_exocyst PF04048.14 ORX58842.1 - 5.3e-38 130.1 0.3 5.3e-38 130.1 0.3 2.8 4 0 0 4 4 4 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 ORX58842.1 - 7.2e-06 26.0 0.0 3.1e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Zw10 PF06248.13 ORX58842.1 - 8.6e-05 21.3 3.1 0.00031 19.4 2.3 2.0 2 0 0 2 2 2 1 Centromere/kinetochore Zw10 Hormone_1 PF00103.20 ORX58842.1 - 5 6.8 11.0 1.4 8.7 0.1 3.0 3 0 0 3 3 3 0 Somatotropin hormone family cNMP_binding PF00027.29 ORX58843.1 - 1.1e-35 121.5 0.0 6.1e-16 58.3 0.0 5.4 5 0 0 5 5 5 5 Cyclic nucleotide-binding domain Patatin PF01734.22 ORX58843.1 - 1.3e-20 74.4 2.4 5.3e-20 72.5 2.4 2.1 1 1 0 1 1 1 1 Patatin-like phospholipase E3_UFM1_ligase PF09743.9 ORX58844.1 - 6.4e-34 117.8 0.2 1.5e-32 113.4 0.0 2.1 2 0 0 2 2 2 2 E3 UFM1-protein ligase 1 SH3_1 PF00018.28 ORX58845.1 - 4e-12 45.6 0.7 7e-12 44.8 0.0 1.7 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ORX58845.1 - 3.7e-10 39.3 0.2 9.8e-10 38.0 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 ORX58845.1 - 1.8e-08 34.1 0.0 3.3e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ORX58845.1 - 0.016 15.5 0.1 0.033 14.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain DUF2244 PF10003.9 ORX58845.1 - 5.4 6.7 6.5 9.9 5.8 6.5 1.5 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) FA_desaturase PF00487.24 ORX58846.1 - 1e-37 130.4 20.2 1e-37 130.4 20.2 1.5 2 0 0 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 ORX58846.1 - 8.1e-17 61.1 0.1 2.3e-16 59.7 0.1 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2207 PF09972.9 ORX58846.1 - 3.9 6.1 5.6 9.3 4.9 5.6 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CLTH PF10607.9 ORX58847.1 - 3.8e-23 82.0 0.1 6.5e-23 81.3 0.1 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ORX58847.1 - 4.7e-05 23.2 0.0 0.0003 20.6 0.0 2.1 2 0 0 2 2 2 1 LisH TSA PF03249.13 ORX58847.1 - 0.12 11.1 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Type specific antigen Metallothio_2 PF01439.18 ORX58849.1 - 0.0034 18.2 5.3 0.0082 17.0 5.3 1.6 1 0 0 1 1 1 1 Metallothionein Copper-fist PF00649.18 ORX58850.1 - 8.3e-22 76.4 0.9 8.3e-22 76.4 0.9 2.2 2 1 0 2 2 2 1 Copper fist DNA binding domain DUF3716 PF12511.8 ORX58850.1 - 0.019 15.0 8.5 0.2 11.7 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Arg_repressor PF01316.21 ORX58850.1 - 0.095 12.5 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain SPX PF03105.19 ORX58851.1 - 4.4e-34 119.0 14.8 4.5e-14 53.2 4.1 3.1 1 1 1 3 3 3 3 SPX domain CitMHS PF03600.16 ORX58851.1 - 3.1e-29 102.1 34.2 1.1e-18 67.4 16.1 2.2 1 1 1 2 2 2 2 Citrate transporter Na_sulph_symp PF00939.19 ORX58851.1 - 1.1e-23 84.1 32.6 1.5e-23 83.6 32.6 1.2 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region Hemerythrin PF01814.23 ORX58851.1 - 0.05 14.2 0.2 3.7 8.2 0.0 2.4 2 0 0 2 2 2 0 Hemerythrin HHE cation binding domain Viral_protease PF08715.10 ORX58852.1 - 0.075 12.4 0.0 0.079 12.3 0.0 1.0 1 0 0 1 1 1 0 Papain like viral protease COPI_assoc PF08507.10 ORX58853.1 - 8.3e-27 93.8 18.2 1.1e-26 93.4 18.2 1.1 1 0 0 1 1 1 1 COPI associated protein BaxI_1 PF12811.7 ORX58853.1 - 0.18 11.3 13.2 0.27 10.7 12.8 1.4 1 1 0 1 1 1 0 Bax inhibitor 1 like DUF373 PF04123.13 ORX58853.1 - 2 7.8 9.4 2.4 7.5 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) SdpI PF13630.6 ORX58853.1 - 8.9 6.5 16.2 0.36 11.0 4.8 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family Pam17 PF08566.10 ORX58854.1 - 3.8e-56 189.5 0.0 4.7e-56 189.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 O-FucT PF10250.9 ORX58855.1 - 0.019 14.7 0.0 3.5 7.2 0.0 2.4 2 0 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase RabGAP-TBC PF00566.18 ORX58856.1 - 1.1e-55 188.7 0.5 1.1e-55 188.7 0.5 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain TMCO5 PF14992.6 ORX58856.1 - 0.0039 16.8 9.8 0.0067 16.0 9.8 1.2 1 0 0 1 1 1 1 TMCO5 family CENP-H PF05837.12 ORX58856.1 - 0.0071 16.8 13.2 0.016 15.6 7.2 2.3 2 0 0 2 2 2 1 Centromere protein H (CENP-H) YabA PF06156.13 ORX58856.1 - 0.018 15.7 14.3 0.06 14.0 2.0 2.8 1 1 1 2 2 2 0 Initiation control protein YabA Fez1 PF06818.15 ORX58856.1 - 0.12 12.8 7.0 0.22 11.9 7.0 1.3 1 0 0 1 1 1 0 Fez1 DUF2205 PF10224.9 ORX58856.1 - 0.17 11.9 4.0 1.6 8.8 0.1 2.6 2 0 0 2 2 2 0 Short coiled-coil protein Tropomyosin PF00261.20 ORX58856.1 - 0.17 11.2 5.6 0.46 9.8 0.4 2.1 2 0 0 2 2 2 0 Tropomyosin DUF2353 PF09789.9 ORX58856.1 - 0.38 10.1 11.1 0.067 12.5 3.3 2.1 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DivIC PF04977.15 ORX58856.1 - 0.43 10.4 19.9 0.042 13.6 1.0 3.3 3 0 0 3 3 3 0 Septum formation initiator Filament PF00038.21 ORX58856.1 - 0.47 10.0 13.4 2.3 7.7 0.4 2.1 2 0 0 2 2 2 0 Intermediate filament protein Mod_r PF07200.13 ORX58856.1 - 0.63 10.1 14.1 3 8.0 1.1 3.1 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Snapin_Pallidin PF14712.6 ORX58856.1 - 0.88 10.0 13.8 0.35 11.3 6.0 2.6 2 0 0 2 2 2 0 Snapin/Pallidin Tropomyosin_1 PF12718.7 ORX58856.1 - 0.88 9.7 9.9 6 7.0 3.4 2.3 2 0 0 2 2 2 0 Tropomyosin like KASH_CCD PF14662.6 ORX58856.1 - 1.1 9.0 19.8 5.8 6.7 19.9 2.0 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH ROS_MUCR PF05443.11 ORX58856.1 - 1.3 9.1 3.5 6.6 6.8 0.8 2.5 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein CENP-F_leu_zip PF10473.9 ORX58856.1 - 2 8.5 13.0 3.9 7.5 0.5 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_MT_bd PF06657.13 ORX58856.1 - 2.3 8.7 9.3 1.1 9.7 2.2 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Seryl_tRNA_N PF02403.22 ORX58856.1 - 3.1 8.1 9.7 4 7.7 0.7 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 ORX58856.1 - 3.3 7.9 20.3 0.69 10.1 11.1 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PspA_IM30 PF04012.12 ORX58856.1 - 3.3 7.2 11.8 1.5 8.3 2.2 2.2 2 0 0 2 2 2 0 PspA/IM30 family APG6_N PF17675.1 ORX58856.1 - 3.5 8.2 21.6 0.81 10.2 3.9 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 ORX58856.1 - 4.6 7.7 24.2 4.3 7.8 3.2 3.3 2 1 1 3 3 3 0 Cell division protein ZapB Spc24 PF08286.11 ORX58856.1 - 7.9 6.8 9.0 10 6.5 2.2 2.4 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 K-box PF01486.17 ORX58856.1 - 8.9 6.6 13.2 51 4.1 11.3 2.8 1 1 1 2 2 2 0 K-box region Histone PF00125.24 ORX58860.1 - 2.1e-06 28.1 0.2 1e-05 25.9 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 MRP-L20 PF12824.7 ORX58860.1 - 0.035 14.3 0.1 0.061 13.5 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 CENP-T_C PF15511.6 ORX58860.1 - 0.14 12.3 0.0 0.22 11.7 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ORX58860.1 - 0.15 12.3 0.0 0.31 11.4 0.0 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone 4HBT PF03061.22 ORX58861.1 - 4.5e-10 39.8 0.0 6.1e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ORX58861.1 - 4.3e-06 26.2 0.3 0.00072 18.9 0.7 2.0 1 1 0 2 2 2 2 Acyl-ACP thioesterase 4HBT_2 PF13279.6 ORX58861.1 - 0.00014 22.3 0.0 0.00021 21.8 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily Calreticulin PF00262.18 ORX58862.1 - 3.8e-81 272.8 17.7 8.6e-61 205.8 5.9 2.1 1 1 1 2 2 2 2 Calreticulin family DEAD PF00270.29 ORX58863.1 - 1.7e-50 171.2 0.0 6.6e-50 169.3 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX58863.1 - 3.9e-31 107.7 0.0 6.6e-30 103.7 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX58863.1 - 1.6e-06 28.2 0.0 3e-06 27.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX58863.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF3939 PF13075.6 ORX58863.1 - 0.055 13.5 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3939) IGPD PF00475.18 ORX58864.1 - 3e-61 206.0 0.5 3.8e-61 205.6 0.5 1.1 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase SET PF00856.28 ORX58865.1 - 5.3e-21 75.7 0.2 2.3e-20 73.7 0.2 2.0 1 1 0 1 1 1 1 SET domain Aldedh PF00171.22 ORX58866.1 - 1.7e-179 597.2 0.2 2e-179 597.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ORX58866.1 - 0.096 12.1 0.0 0.7 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) CybS PF05328.12 ORX58867.1 - 8.6e-37 125.8 0.0 1e-36 125.6 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit CTP_transf_like PF01467.26 ORX58868.1 - 3.6e-30 105.0 0.0 5.1e-30 104.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF3631 PF12307.8 ORX58868.1 - 0.031 14.5 0.0 2.6 8.2 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3631) RF-1 PF00472.20 ORX58870.1 - 1.2e-22 80.1 2.7 1.4e-22 79.8 2.7 1.1 1 0 0 1 1 1 1 RF-1 domain HAT_KAT11 PF08214.11 ORX58871.1 - 1.7e-40 139.4 0.0 2.6e-40 138.8 0.0 1.2 1 0 0 1 1 1 1 Histone acetylation protein Cu-oxidase_2 PF07731.14 ORX58872.1 - 0.014 15.2 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Multicopper oxidase Phage_Integr_2 PF13009.6 ORX58872.1 - 0.037 13.1 0.0 0.066 12.3 0.0 1.4 1 1 1 2 2 2 0 Putative phage integrase W2 PF02020.18 ORX58873.1 - 9.5e-15 54.5 2.3 1.4e-12 47.5 0.4 3.0 3 0 0 3 3 3 2 eIF4-gamma/eIF5/eIF2-epsilon DUF5082 PF16888.5 ORX58873.1 - 0.058 13.7 0.2 0.058 13.7 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Cnn_1N PF07989.11 ORX58873.1 - 0.15 12.2 1.8 0.33 11.2 1.8 1.6 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 DUF2992 PF11208.8 ORX58873.1 - 0.33 11.2 1.5 0.63 10.3 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) DivIC PF04977.15 ORX58873.1 - 3 7.7 4.5 2.1 8.2 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator ZapB PF06005.12 ORX58873.1 - 3 8.4 5.6 21 5.7 5.7 2.2 1 1 0 1 1 1 0 Cell division protein ZapB FAD_binding_3 PF01494.19 ORX58874.1 - 6.7e-18 65.0 1.1 2.7e-09 36.7 0.1 3.1 3 0 0 3 3 3 3 FAD binding domain NAD_binding_8 PF13450.6 ORX58874.1 - 3.4e-05 24.0 0.0 7.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ORX58874.1 - 0.00075 18.7 0.2 0.0027 16.8 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX58874.1 - 0.0077 15.5 0.1 0.089 12.0 0.0 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX58874.1 - 0.01 15.5 0.0 0.018 14.6 0.0 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ORX58874.1 - 0.015 15.8 0.0 0.11 13.0 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX58874.1 - 0.022 14.0 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX58874.1 - 0.025 13.6 0.0 0.39 9.7 0.0 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein HI0933_like PF03486.14 ORX58874.1 - 0.17 10.5 0.0 0.32 9.6 0.0 1.4 1 0 0 1 1 1 0 HI0933-like protein TrkA_N PF02254.18 ORX58874.1 - 0.18 12.1 0.2 28 5.0 0.0 3.0 3 0 0 3 3 3 0 TrkA-N domain Pyridoxal_deC PF00282.19 ORX58875.1 - 2.3e-78 263.5 0.0 2.8e-78 263.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 ORX58875.1 - 9.6e-08 31.6 0.0 1.6e-07 30.9 0.0 1.3 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ORX58875.1 - 0.00026 20.0 0.0 0.00072 18.6 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class-V RasGEF PF00617.19 ORX58876.1 - 1.9e-60 204.1 0.6 5.4e-60 202.6 0.6 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX58876.1 - 1.7e-25 89.3 1.8 5.5e-25 87.6 1.8 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 ORX58876.1 - 7.2e-16 57.5 0.0 2.2e-15 55.9 0.0 1.9 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX58876.1 - 2.5e-10 39.9 0.0 4.9e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX58876.1 - 4.7e-10 39.2 0.3 1.6e-09 37.5 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Met_synt_B12 PF02965.17 ORX58878.1 - 2.1e-122 407.8 0.0 3.7e-122 407.0 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain S-methyl_trans PF02574.16 ORX58878.1 - 1.3e-79 267.9 0.0 2.5e-79 266.9 0.0 1.5 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Pterin_bind PF00809.22 ORX58878.1 - 1.2e-53 182.3 0.1 3.6e-53 180.8 0.1 1.9 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 ORX58878.1 - 4e-24 84.8 0.2 2.1e-23 82.6 0.2 2.4 1 0 0 1 1 1 1 B12 binding domain B12-binding PF02310.19 ORX58878.1 - 1.1e-17 64.2 1.6 7.6e-17 61.5 0.4 2.8 2 1 1 3 3 3 1 B12 binding domain CdhD PF03599.16 ORX58878.1 - 0.011 14.5 0.3 0.056 12.1 0.0 2.3 3 0 0 3 3 3 0 CO dehydrogenase/acetyl-CoA synthase delta subunit Yippee-Mis18 PF03226.14 ORX58879.1 - 2.7e-14 53.2 1.0 3.1e-14 53.1 1.0 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly MRP_L53 PF10780.9 ORX58880.1 - 1.2e-11 44.6 0.1 1.7e-11 44.1 0.1 1.3 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 HSF_DNA-bind PF00447.17 ORX58881.1 - 1.8e-31 108.6 3.5 1.8e-31 108.6 3.5 2.0 2 1 0 2 2 2 1 HSF-type DNA-binding CNDH2_N PF06278.11 ORX58881.1 - 0.23 11.7 3.9 0.42 10.8 3.9 1.5 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal DUF948 PF06103.11 ORX58881.1 - 0.69 10.2 3.6 1.6 9.1 3.6 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HIP1_clath_bdg PF16515.5 ORX58881.1 - 1.4 9.5 11.5 1.5 9.4 10.5 1.5 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4200 PF13863.6 ORX58881.1 - 1.7 9.0 10.7 0.19 12.1 6.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) ADH_zinc_N PF00107.26 ORX58882.1 - 3.6e-34 117.5 0.1 5.4e-34 117.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX58882.1 - 4.1e-15 57.0 0.0 1.1e-14 55.6 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX58882.1 - 9.6e-09 35.1 0.0 2.5e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ORX58882.1 - 0.00032 20.6 0.1 0.00081 19.3 0.1 1.7 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase AlaDh_PNT_C PF01262.21 ORX58882.1 - 0.0046 16.3 0.6 0.0086 15.4 0.6 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 ORX58882.1 - 0.014 15.7 0.0 0.024 14.9 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain PALP PF00291.25 ORX58882.1 - 0.024 14.0 0.9 0.04 13.3 0.9 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Glyco_hydro_98M PF08306.11 ORX58882.1 - 0.17 11.2 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 Thioredoxin PF00085.20 ORX58883.1 - 3.8e-41 139.2 0.0 2.2e-20 72.6 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 ORX58883.1 - 4.6e-23 82.1 0.0 2.5e-18 66.6 0.0 3.1 2 1 1 3 3 3 2 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ORX58883.1 - 5.6e-08 33.2 0.0 0.0019 18.6 0.0 3.8 4 0 0 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 ORX58883.1 - 3.7e-05 23.2 0.3 0.55 9.5 0.0 3.0 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 ORX58883.1 - 5.4e-05 23.4 0.2 0.24 11.7 0.0 4.6 5 1 1 6 6 6 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ORX58883.1 - 0.0039 17.3 0.6 0.078 13.2 0.0 3.2 4 0 0 4 4 4 1 Thioredoxin-like Thioredoxin_4 PF13462.6 ORX58883.1 - 0.012 15.8 0.5 10 6.2 0.0 3.5 3 0 0 3 3 3 0 Thioredoxin Thioredoxin_3 PF13192.6 ORX58883.1 - 0.016 15.2 0.0 0.95 9.6 0.0 2.8 3 0 0 3 3 3 0 Thioredoxin domain TraF PF13728.6 ORX58883.1 - 1.4 8.7 4.9 1.7 8.4 0.0 2.9 3 0 0 3 3 3 0 F plasmid transfer operon protein Glyco_hydro_16 PF00722.21 ORX58884.1 - 7.3e-15 54.9 0.0 1.3e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 lci PF12197.8 ORX58884.1 - 0.0067 16.2 0.3 1.5 8.7 0.1 2.6 2 0 0 2 2 2 2 Bacillus cereus group antimicrobial protein Fmp27_WPPW PF10359.9 ORX58885.1 - 0.17 10.7 0.0 0.2 10.5 0.0 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain SlyX PF04102.12 ORX58887.1 - 0.2 12.3 1.8 0.39 11.4 1.0 1.9 1 1 1 2 2 2 0 SlyX DUF2254 PF10011.9 ORX58888.1 - 0.58 8.9 5.1 0.67 8.7 5.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) IMUP PF15761.5 ORX58888.1 - 1.6 9.4 5.7 17 6.1 0.3 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein GTP_EFTU PF00009.27 ORX58889.1 - 4.4e-51 173.2 0.0 6.6e-51 172.6 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 ORX58889.1 - 7.3e-38 129.9 11.4 1.3e-37 129.1 11.4 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 ORX58889.1 - 2.4e-23 82.2 0.0 7.1e-23 80.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ORX58889.1 - 4.4e-23 81.1 0.0 1e-22 79.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ORX58889.1 - 3.7e-10 40.0 0.1 9.4e-10 38.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ORX58889.1 - 6.9e-06 26.1 0.0 1.4e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ORX58889.1 - 0.00014 21.9 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX58889.1 - 0.023 14.8 0.0 0.4 10.7 0.0 2.4 1 1 0 2 2 2 0 Dynamin family Pkinase PF00069.25 ORX58890.1 - 1.9e-72 243.8 0.0 2.4e-72 243.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58890.1 - 2.2e-34 118.9 0.0 2.9e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX58890.1 - 7.9e-06 25.4 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX58890.1 - 0.17 11.2 0.0 0.33 10.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF155 PF02582.14 ORX58891.1 - 8.3e-55 185.6 0.5 1.2e-54 185.1 0.5 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 DUF1073 PF06381.11 ORX58891.1 - 0.2 10.4 2.6 0.42 9.3 2.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1073) MCD_N PF17408.2 ORX58892.1 - 0.15 12.2 4.0 0.41 10.8 4.0 1.8 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase N-terminal domain V_ATPase_I PF01496.19 ORX58892.1 - 0.15 9.9 3.0 0.18 9.7 3.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF501 PF04417.12 ORX58892.1 - 0.6 9.9 5.6 1.2 9.0 5.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF501) TetR_C_13 PF16925.5 ORX58892.1 - 0.63 10.0 3.1 1.1 9.2 3.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Atg14 PF10186.9 ORX58892.1 - 0.63 9.1 8.4 0.87 8.6 8.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cir_N PF10197.9 ORX58892.1 - 1.8 8.8 10.0 2.6 8.3 5.3 2.7 2 0 0 2 2 2 0 N-terminal domain of CBF1 interacting co-repressor CIR Hydrolase_3 PF08282.12 ORX58894.1 - 0.0029 17.4 0.0 0.0038 17.0 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SWIM PF04434.17 ORX58894.1 - 0.074 12.7 0.2 0.16 11.7 0.2 1.5 1 0 0 1 1 1 0 SWIM zinc finger DER1 PF04511.15 ORX58896.1 - 6.9e-42 143.6 5.7 8e-42 143.3 5.7 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 ORX58896.1 - 0.028 14.4 6.0 0.077 13.0 6.0 1.9 1 1 0 1 1 1 0 Rhomboid family Cytochrom_C1 PF02167.15 ORX58897.1 - 1.1e-96 322.7 0.0 1.3e-96 322.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ORX58897.1 - 0.00095 19.4 0.0 0.0022 18.3 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ORX58897.1 - 0.04 15.1 0.2 0.13 13.5 0.2 2.0 2 1 0 2 2 2 0 Cytochrome c NUDE_C PF04880.13 ORX58898.1 - 5.1e-17 62.9 7.4 5.1e-17 62.9 7.4 2.3 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region TPR_MLP1_2 PF07926.12 ORX58898.1 - 0.00019 21.5 33.6 0.0008 19.5 4.3 3.3 3 1 1 4 4 4 2 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 ORX58898.1 - 0.0016 16.1 26.4 0.0021 15.7 26.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Rab5-bind PF09311.11 ORX58898.1 - 0.012 15.0 3.4 0.012 15.0 3.4 2.6 2 1 1 3 3 3 0 Rabaptin-like protein PRKG1_interact PF15898.5 ORX58898.1 - 0.21 12.5 30.5 2.4 9.1 1.4 3.6 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain PSII_Pbs27 PF13326.6 ORX58898.1 - 1.6 9.1 6.1 0.26 11.6 1.2 2.1 2 1 0 2 2 2 0 Photosystem II Pbs27 CENP-Q PF13094.6 ORX58898.1 - 2 8.6 36.1 6.2 7.0 16.1 2.9 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Fib_alpha PF08702.10 ORX58898.1 - 2.1 8.5 21.8 0.35 11.0 11.2 2.9 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family Tweety PF04906.13 ORX58898.1 - 2.2 6.9 10.6 5.7 5.5 4.4 2.4 1 1 0 2 2 2 0 Tweety ISG65-75 PF11727.8 ORX58898.1 - 5.6 6.1 14.6 6 6.0 3.2 2.3 2 0 0 2 2 2 0 Invariant surface glycoprotein TMF_TATA_bd PF12325.8 ORX58898.1 - 7.8 6.8 39.1 1.6 9.0 0.2 4.2 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 ORX58898.1 - 8.9 5.6 35.3 12 5.1 7.1 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding zf-C4pol PF14260.6 ORX58898.1 - 9 6.8 5.9 8 7.0 0.2 3.3 3 1 0 3 3 3 0 C4-type zinc-finger of DNA polymerase delta Fe_hyd_lg_C PF02906.14 ORX58899.1 - 2.4e-76 256.6 0.0 2.2e-74 250.2 0.0 2.9 2 1 0 2 2 2 1 Iron only hydrogenase large subunit, C-terminal domain Fe_hyd_SSU PF02256.17 ORX58899.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Iron hydrogenase small subunit Iso_dh PF00180.20 ORX58901.1 - 1.2e-80 271.3 0.0 1.3e-80 271.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PX PF00787.24 ORX58902.1 - 1.7e-23 82.7 3.1 1.7e-23 82.7 3.1 2.6 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 ORX58902.1 - 3e-08 33.5 6.8 4.5e-06 26.4 2.6 2.2 2 0 0 2 2 2 2 Vps5 C terminal like CENP-Q PF13094.6 ORX58902.1 - 0.019 15.2 4.0 0.019 15.2 4.0 2.9 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4404 PF14357.6 ORX58902.1 - 0.019 15.6 2.2 0.019 15.6 2.2 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4404) Duffy_binding PF05424.11 ORX58902.1 - 0.066 13.2 0.8 0.12 12.4 0.8 1.5 1 0 0 1 1 1 0 Duffy binding domain FTA4 PF13093.6 ORX58902.1 - 0.76 9.6 6.4 35 4.2 6.4 2.5 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 GrpE PF01025.19 ORX58902.1 - 4.6 6.9 8.8 1.9 8.1 6.1 1.8 2 0 0 2 2 2 0 GrpE Med1 PF10744.9 ORX58903.1 - 2.8e-43 148.5 0.7 4.6e-43 147.8 0.7 1.3 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 EamA PF00892.20 ORX58904.1 - 4.8e-14 52.7 23.6 7.5e-09 35.9 9.3 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF1453 PF07301.11 ORX58904.1 - 0.038 14.0 1.2 0.038 14.0 1.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1453) Alginate_lyase PF05426.12 ORX58905.1 - 1.8e-37 129.4 0.0 2.4e-37 129.0 0.0 1.1 1 0 0 1 1 1 1 Alginate lyase Tubulin PF00091.25 ORX58906.1 - 3.6e-71 239.4 0.0 5.5e-71 238.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX58906.1 - 3e-41 140.5 0.0 4.8e-41 139.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ORX58906.1 - 1e-05 25.8 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ORX58906.1 - 0.035 13.8 0.0 0.067 12.9 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 ORX58906.1 - 0.039 13.2 0.0 0.072 12.3 0.0 1.4 1 0 0 1 1 1 0 Tubulin like O-FucT PF10250.9 ORX58907.1 - 1e-07 32.0 0.0 2.3e-07 30.8 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase XRCC4 PF06632.12 ORX58908.1 - 1.4e-10 40.5 5.2 3.6e-10 39.2 4.8 1.8 1 1 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 UPF0184 PF03670.13 ORX58908.1 - 0.0044 17.4 2.2 0.0044 17.4 2.2 1.6 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0184) PKcGMP_CC PF16808.5 ORX58908.1 - 0.038 13.8 0.3 0.067 13.0 0.3 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase IR1-M PF12185.8 ORX58908.1 - 0.11 12.4 0.1 0.31 11.0 0.1 1.8 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain Glutaredoxin2_C PF04399.13 ORX58908.1 - 0.6 10.0 3.3 3.3 7.6 0.1 2.5 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain HR1 PF02185.16 ORX58908.1 - 3.6 7.8 11.9 1.4 9.1 0.8 2.6 2 1 1 3 3 3 0 Hr1 repeat SHE3 PF17078.5 ORX58908.1 - 5.1 6.7 12.1 6.8 6.3 5.8 2.5 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 zf-H2C2_2 PF13465.6 ORX58910.1 - 2.9e-10 40.1 3.8 4e-08 33.3 0.2 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 ORX58910.1 - 3.8e-09 36.5 6.4 0.00054 20.3 2.7 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX58910.1 - 6.4e-07 29.7 6.9 0.0056 17.4 2.2 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX58910.1 - 1.9e-06 28.0 0.3 0.082 13.2 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX58910.1 - 8.6e-05 22.2 3.8 0.058 13.2 0.1 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 ORX58910.1 - 0.0011 19.3 2.1 0.053 13.9 0.1 2.3 2 1 1 3 3 2 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 ORX58910.1 - 0.0031 17.9 0.8 0.55 10.7 0.2 2.3 1 1 1 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-H2C2_5 PF13909.6 ORX58910.1 - 0.0072 16.1 3.0 0.33 10.7 0.5 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-LYAR PF08790.11 ORX58910.1 - 0.067 13.1 0.2 2.4 8.2 0.0 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-BED PF02892.15 ORX58910.1 - 0.14 12.2 0.8 3.3 7.8 0.2 2.3 1 1 1 2 2 2 0 BED zinc finger DUF629 PF04780.12 ORX58910.1 - 0.21 10.1 0.9 0.24 9.9 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF629) zf_C2H2_ZHX PF18387.1 ORX58910.1 - 0.28 10.9 4.6 1.7 8.3 0.2 2.2 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Rad21_Rec8_N PF04825.13 ORX58911.1 - 1.6e-05 25.0 0.1 3e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 ORX58911.1 - 0.003 16.8 0.0 0.0059 15.9 0.0 1.4 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein SDA1 PF05285.12 ORX58912.1 - 0.052 13.0 11.7 0.01 15.3 8.4 1.4 1 1 0 1 1 1 0 SDA1 YL1 PF05764.13 ORX58912.1 - 0.33 11.0 12.8 0.66 10.0 12.8 1.5 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 ORX58912.1 - 1.8 7.9 15.9 2.9 7.1 15.9 1.4 1 1 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 ORX58912.1 - 8.2 4.4 18.6 13 3.8 18.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi SPG48 PF14764.6 ORX58913.1 - 0.041 14.4 0.8 0.11 13.0 0.8 1.7 1 0 0 1 1 1 0 AP-5 complex subunit, vesicle trafficking Pkinase PF00069.25 ORX58914.1 - 3.4e-52 177.4 0.0 6.4e-52 176.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58914.1 - 4e-20 72.2 0.0 5.9e-20 71.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Fn3_assoc PF13287.6 ORX58914.1 - 0.09 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Fn3 associated Methyltransf_PK PF05891.12 ORX58916.1 - 1.8e-77 259.8 0.0 2.1e-77 259.6 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 ORX58916.1 - 2.2e-10 41.1 0.0 3.3e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX58916.1 - 6.5e-08 33.1 0.0 9.4e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX58916.1 - 3.8e-07 30.8 0.0 5.8e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX58916.1 - 4e-07 30.0 0.0 4.5e-06 26.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX58916.1 - 0.00026 20.4 0.0 0.00034 20.0 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain MTS PF05175.14 ORX58916.1 - 0.0019 17.8 0.0 0.0026 17.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Exo_endo_phos PF03372.23 ORX58917.1 - 4.9e-19 68.8 0.8 2.2e-17 63.3 0.7 2.4 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 ORX58917.1 - 1.6e-09 37.9 10.5 1.5e-05 25.2 0.4 2.8 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ORX58917.1 - 2.8e-08 33.4 6.0 5.2e-05 22.9 0.9 2.5 1 1 1 2 2 2 2 Leucine rich repeat LRR_1 PF00560.33 ORX58917.1 - 0.00022 21.4 6.1 1.7 9.5 0.3 4.8 4 0 0 4 4 4 2 Leucine Rich Repeat Mid2 PF04478.12 ORX58918.1 - 0.076 12.9 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor DUF1951 PF09188.10 ORX58918.1 - 0.14 12.2 0.0 0.26 11.2 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1951) MIF4G PF02854.19 ORX58919.1 - 1e-31 110.2 4.8 5.2e-31 107.9 1.3 2.3 2 0 0 2 2 2 2 MIF4G domain MA3 PF02847.17 ORX58919.1 - 1.1e-21 76.9 0.0 3.7e-21 75.2 0.0 2.0 1 0 0 1 1 1 1 MA3 domain Prp18 PF02840.15 ORX58919.1 - 0.1 12.6 0.2 0.1 12.6 0.2 3.1 4 0 0 4 4 4 0 Prp18 domain COX6B PF02297.17 ORX58920.1 - 7.6e-20 70.9 7.0 9.1e-20 70.7 7.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb APOBEC_C PF05240.14 ORX58920.1 - 0.0054 16.6 0.5 0.0068 16.3 0.5 1.2 1 0 0 1 1 1 1 APOBEC-like C-terminal domain E1-E2_ATPase PF00122.20 ORX58921.1 - 1.2e-40 138.9 2.8 1.2e-40 138.9 2.8 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX58921.1 - 9.5e-20 71.1 1.5 9.5e-20 71.1 1.5 2.8 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 ORX58921.1 - 4e-17 61.7 0.2 8.8e-16 57.4 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX58921.1 - 1.9e-16 59.9 0.0 4.7e-16 58.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX58921.1 - 1.4e-15 58.2 0.7 1.5e-13 51.5 0.7 3.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX58921.1 - 0.0018 18.1 1.8 0.005 16.6 0.6 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX58921.1 - 0.023 15.1 0.0 0.058 13.8 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase FtsX PF02687.21 ORX58921.1 - 1.4 9.5 5.9 2.2 8.8 1.6 3.0 2 0 0 2 2 2 0 FtsX-like permease family S_4TM PF18159.1 ORX58921.1 - 10 5.4 9.8 1.6 7.9 0.9 3.0 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain DUF4618 PF15397.6 ORX58922.1 - 0.012 15.0 4.5 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) PhoD PF09423.10 ORX58923.1 - 1.8e-06 27.3 0.1 0.0087 15.1 0.1 2.3 2 0 0 2 2 2 2 PhoD-like phosphatase Pkinase PF00069.25 ORX58924.1 - 2.3e-51 174.7 0.2 5.8e-39 134.0 0.1 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58924.1 - 2.7e-19 69.5 0.0 7.5e-19 68.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX58924.1 - 2.2e-05 23.9 0.0 5.2e-05 22.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX58924.1 - 4.6e-05 22.4 0.1 6e-05 22.0 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ORX58924.1 - 0.00015 21.2 1.5 0.00025 20.5 1.5 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX58924.1 - 0.0024 16.9 0.6 0.0034 16.4 0.6 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX58924.1 - 0.0034 17.3 0.1 0.0086 16.0 0.2 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Myb_DNA-binding PF00249.31 ORX58925.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Myb-like DNA-binding domain SLD3 PF08639.10 ORX58926.1 - 2.5e-06 26.6 16.2 0.00055 18.8 16.2 2.6 1 1 0 1 1 1 1 DNA replication regulator SLD3 DASH_Duo1 PF08651.10 ORX58926.1 - 0.1 12.4 1.0 2.5 7.9 0.2 3.3 4 0 0 4 4 4 0 DASH complex subunit Duo1 Peptidase_S46 PF10459.9 ORX58926.1 - 1.5 7.4 5.2 2.7 6.5 5.2 1.3 1 0 0 1 1 1 0 Peptidase S46 Spc7 PF08317.11 ORX58928.1 - 2e-07 30.2 15.5 2e-07 30.2 15.5 9.9 3 1 6 10 10 10 4 Spc7 kinetochore protein HrpB7 PF09486.10 ORX58928.1 - 0.0063 16.9 11.8 0.0063 16.9 11.8 10.4 3 1 7 11 11 11 1 Bacterial type III secretion protein (HrpB7) UPF0242 PF06785.11 ORX58928.1 - 0.008 16.3 6.3 0.008 16.3 6.3 10.2 3 2 7 10 10 10 4 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 ORX58928.1 - 0.01 16.0 5.0 0.01 16.0 5.0 11.3 1 1 8 12 12 12 0 Fibrinogen alpha/beta chain family CinA_KH PF18146.1 ORX58928.1 - 1.7 8.9 8.7 3.9 7.7 0.7 4.5 3 0 0 3 3 3 0 Damage-inducible protein CinA KH domain SHNi-TPR PF10516.9 ORX58928.1 - 3.7 7.1 7.4 0.14 11.6 0.6 2.3 2 0 0 2 2 2 0 SHNi-TPR E1-E2_ATPase PF00122.20 ORX58929.1 - 1.8e-42 144.9 9.3 2.5e-42 144.5 1.9 3.1 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX58929.1 - 4.5e-24 85.1 2.7 4.5e-24 85.1 2.7 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX58929.1 - 4.5e-19 68.3 0.0 9.5e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX58929.1 - 1.5e-15 56.6 0.1 2.2e-14 52.9 0.0 2.5 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 ORX58929.1 - 2.3e-15 57.5 0.3 1.5e-12 48.3 0.1 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX58929.1 - 0.0019 18.0 0.9 0.0058 16.4 0.5 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Borrelia_P13 PF05628.12 ORX58929.1 - 0.0068 16.4 1.5 0.033 14.2 0.0 2.5 2 1 0 2 2 2 1 Borrelia membrane protein P13 HAD PF12710.7 ORX58929.1 - 0.016 15.6 0.0 0.056 13.8 0.0 2.0 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF3671 PF12420.8 ORX58929.1 - 8 6.6 7.6 16 5.6 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function DUF202 PF02656.15 ORX58930.1 - 4.7e-24 84.6 0.7 4.7e-24 84.6 0.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF202) UAA PF08449.11 ORX58930.1 - 0.0013 18.1 0.2 0.0016 17.7 0.2 1.1 1 0 0 1 1 1 1 UAA transporter family YtpI PF14007.6 ORX58930.1 - 0.0038 17.3 4.8 0.005 16.9 3.2 1.9 1 1 1 2 2 2 1 YtpI-like protein COX2-transmemb PF09125.10 ORX58930.1 - 0.032 14.0 0.4 9.6 6.1 0.2 2.5 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane DUF1980 PF09323.10 ORX58930.1 - 0.13 12.1 1.1 0.14 12.0 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) CD20 PF04103.15 ORX58930.1 - 0.35 11.0 5.2 0.72 9.9 3.6 1.9 2 0 0 2 2 2 0 CD20-like family Syndecan PF01034.20 ORX58930.1 - 0.94 9.4 3.2 7.5 6.5 0.1 2.3 2 0 0 2 2 2 0 Syndecan domain SR-25 PF10500.9 ORX58931.1 - 4 7.0 6.6 25 4.4 3.1 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein LRR_8 PF13855.6 ORX58932.1 - 7.9e-32 108.8 73.2 8.2e-09 35.1 4.5 4.8 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ORX58932.1 - 4.8e-25 87.2 25.1 3.3e-06 27.3 1.1 4.8 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX58932.1 - 1.3e-08 34.2 26.9 1.1 10.1 0.2 9.2 7 1 1 8 8 8 4 Leucine Rich Repeat LRR_9 PF14580.6 ORX58932.1 - 1.7e-06 27.6 5.2 0.0025 17.3 0.1 2.3 2 0 0 2 2 2 2 Leucine-rich repeat LRR_6 PF13516.6 ORX58932.1 - 3.7e-05 23.4 33.4 6.3 7.1 0.7 8.5 9 0 0 9 9 9 6 Leucine Rich repeat Arrestin_C PF02752.22 ORX58933.1 - 1.7e-14 54.4 3.5 3.2e-09 37.3 0.0 3.0 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX58933.1 - 1.1e-08 35.3 0.0 1.2e-07 31.8 0.0 2.2 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Zn_clus PF00172.18 ORX58934.1 - 1.2e-06 28.5 6.8 2.6e-06 27.4 6.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF104 PF01954.16 ORX58934.1 - 0.25 11.8 1.5 0.32 11.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function DUF104 Dak1 PF02733.17 ORX58935.1 - 7.4e-105 350.3 0.3 1.3e-104 349.4 0.3 1.4 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 ORX58935.1 - 3.7e-38 131.2 4.0 7.4e-38 130.2 4.0 1.5 1 0 0 1 1 1 1 DAK2 domain HsbA PF12296.8 ORX58935.1 - 0.014 15.9 0.9 0.014 15.9 0.9 2.2 2 0 0 2 2 2 0 Hydrophobic surface binding protein A Med28 PF11594.8 ORX58935.1 - 0.094 12.8 0.1 0.27 11.3 0.0 1.7 2 0 0 2 2 2 0 Mediator complex subunit 28 Cyclin PF08613.11 ORX58936.1 - 1.4e-08 35.3 0.0 2e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX58936.1 - 0.0042 16.8 0.0 0.0062 16.3 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain TIG PF01833.24 ORX58937.1 - 1.3e-10 41.2 0.1 4e-10 39.6 0.1 1.9 1 0 0 1 1 1 1 IPT/TIG domain CRIM PF16978.5 ORX58937.1 - 0.15 12.2 0.1 26 4.9 0.0 2.4 2 0 0 2 2 2 0 SAPK-interacting protein 1 (Sin1), middle CRIM domain WD40 PF00400.32 ORX58938.1 - 1.2e-34 117.7 11.7 4.2e-07 30.6 0.8 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX58938.1 - 6.3e-09 36.0 3.9 0.038 14.3 0.3 4.6 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX58938.1 - 2.6e-06 26.4 8.4 0.021 13.5 1.2 4.5 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ORX58938.1 - 3.7e-06 25.9 0.5 0.02 13.7 0.1 3.3 1 1 1 2 2 2 2 Nup133 N terminal like Ge1_WD40 PF16529.5 ORX58938.1 - 6.5e-06 25.3 2.7 2.4 7.0 0.0 5.1 2 2 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Hira PF07569.11 ORX58938.1 - 0.00015 21.6 2.0 0.96 9.1 0.7 3.7 1 1 2 3 3 3 2 TUP1-like enhancer of split MMS1_N PF10433.9 ORX58938.1 - 0.0015 17.3 0.0 0.0093 14.6 0.0 2.0 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PALB2_WD40 PF16756.5 ORX58938.1 - 0.003 16.5 2.0 0.0039 16.2 0.0 2.2 3 0 0 3 3 3 1 Partner and localizer of BRCA2 WD40 domain VID27 PF08553.10 ORX58938.1 - 0.0033 16.5 0.0 0.0088 15.1 0.0 1.5 1 1 0 1 1 1 1 VID27 C-terminal WD40-like domain Frtz PF11768.8 ORX58938.1 - 0.028 12.8 0.0 0.12 10.6 0.0 1.9 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Ribosomal_L19 PF01245.20 ORX58939.1 - 3.9e-19 68.6 0.1 4.7e-19 68.4 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L19 Mu-like_Com PF10122.9 ORX58940.1 - 0.099 12.1 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 Mu-like prophage protein Com Glyco_hydro_18 PF00704.28 ORX58941.1 - 3.9e-18 66.2 0.6 4.7e-18 66.0 0.6 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GFA PF04828.14 ORX58942.1 - 8.6e-09 35.6 0.4 8.6e-09 35.6 0.4 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme PHD_Oberon PF07227.11 ORX58942.1 - 0.31 10.9 7.9 0.51 10.2 0.4 2.2 2 0 0 2 2 2 0 PHD - plant homeodomain finger protein PDZ_1 PF12812.7 ORX58943.1 - 5.8e-47 157.6 0.0 4.1e-32 110.0 0.0 2.9 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 ORX58943.1 - 5.5e-20 72.8 0.1 2.2e-16 61.1 0.0 2.6 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 ORX58943.1 - 2.5e-15 56.0 0.0 3.5e-06 26.8 0.0 3.9 4 0 0 4 4 4 3 PDZ domain PDZ_2 PF13180.6 ORX58943.1 - 7.7e-11 42.2 2.1 1.5e-05 25.2 0.0 4.0 4 0 0 4 4 4 2 PDZ domain PDZ PF00595.24 ORX58943.1 - 1.6e-07 31.6 0.0 6.8e-05 23.1 0.0 3.0 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 ORX58943.1 - 0.012 15.5 0.1 0.15 12.0 0.0 2.8 3 0 0 3 3 3 0 Tricorn protease PDZ domain DUF31 PF01732.16 ORX58943.1 - 0.065 12.8 0.2 0.098 12.2 0.2 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Peptidase_S46 PF10459.9 ORX58943.1 - 0.14 10.8 0.3 0.26 9.9 0.0 1.4 2 0 0 2 2 2 0 Peptidase S46 Hist_deacetyl PF00850.19 ORX58944.1 - 5.3e-77 259.3 0.1 6.4e-77 259.0 0.1 1.0 1 0 0 1 1 1 1 Histone deacetylase domain SAM_2 PF07647.17 ORX58946.1 - 8.5e-15 54.6 0.1 1.8e-14 53.5 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 ORX58946.1 - 1.8e-11 44.5 0.0 3.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 ORX58946.1 - 3.9e-09 36.8 0.2 9.9e-09 35.5 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RE_NgoPII PF09521.10 ORX58946.1 - 0.00072 18.8 0.2 0.0012 18.1 0.2 1.3 1 0 0 1 1 1 1 NgoPII restriction endonuclease SAM_4 PF18017.1 ORX58946.1 - 0.011 15.7 0.1 0.047 13.7 0.0 2.1 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Synaptonemal_3 PF15191.6 ORX58946.1 - 0.12 12.1 0.2 0.29 10.9 0.2 1.5 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 ABC_tran PF00005.27 ORX58947.1 - 3.8e-46 157.0 0.0 1e-22 81.1 0.0 4.2 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ORX58947.1 - 3.7e-15 56.5 1.5 2.5e-05 24.2 0.2 4.3 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX58947.1 - 1.7e-14 53.8 0.1 1.1e-05 25.0 0.0 4.5 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ORX58947.1 - 9.9e-08 32.1 0.2 0.0016 18.4 0.0 3.5 3 0 0 3 3 3 2 RsgA GTPase AAA_28 PF13521.6 ORX58947.1 - 1.2e-07 32.1 0.0 0.0056 16.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ORX58947.1 - 1.2e-07 32.0 0.4 0.075 13.3 0.0 4.2 4 0 0 4 4 3 2 AAA domain AAA_16 PF13191.6 ORX58947.1 - 1.9e-07 31.6 0.9 0.0086 16.5 0.0 3.5 3 0 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 ORX58947.1 - 4.8e-07 29.4 0.1 0.02 14.6 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX58947.1 - 8.7e-07 29.0 0.0 0.0078 16.3 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase Chromo PF00385.24 ORX58947.1 - 5.3e-06 26.2 0.4 1.9e-05 24.5 0.4 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA PF00004.29 ORX58947.1 - 7e-06 26.5 0.0 0.1 13.1 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ORX58947.1 - 7.7e-06 26.5 0.9 0.12 12.9 0.0 3.3 3 0 0 3 3 2 2 AAA domain MeaB PF03308.16 ORX58947.1 - 9.7e-06 24.8 0.1 0.071 12.1 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 ORX58947.1 - 1e-05 25.5 2.0 0.14 11.9 0.0 3.3 3 0 0 3 3 3 2 AAA ATPase domain AAA_30 PF13604.6 ORX58947.1 - 1e-05 25.3 0.8 0.38 10.4 0.0 3.9 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 ORX58947.1 - 1.8e-05 25.1 0.0 0.38 11.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 ORX58947.1 - 3.1e-05 24.0 0.0 0.042 13.8 0.0 2.9 3 0 0 3 3 2 1 NACHT domain AAA_33 PF13671.6 ORX58947.1 - 0.00011 22.4 0.1 1.1 9.5 0.0 3.2 2 1 1 3 3 3 2 AAA domain AAA_23 PF13476.6 ORX58947.1 - 0.00015 22.3 13.8 0.029 14.9 0.0 3.9 3 1 0 3 3 3 2 AAA domain DUF815 PF05673.13 ORX58947.1 - 0.00017 20.8 0.0 0.36 9.9 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ORX58947.1 - 0.00036 20.3 0.0 0.47 10.2 0.0 3.1 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 ORX58947.1 - 0.0007 19.6 0.0 0.55 10.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain ParcG PF10274.9 ORX58947.1 - 0.0013 18.9 0.8 0.17 12.0 0.1 2.8 2 1 1 3 3 2 1 Parkin co-regulated protein Rad17 PF03215.15 ORX58947.1 - 0.0023 17.9 0.1 1.8 8.4 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain Adaptin_N PF01602.20 ORX58947.1 - 0.0024 16.5 1.3 0.4 9.2 0.1 2.2 1 1 1 2 2 2 2 Adaptin N terminal region SbcCD_C PF13558.6 ORX58947.1 - 0.0028 17.8 0.0 0.37 11.1 0.0 3.2 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF87 PF01935.17 ORX58947.1 - 0.0039 17.3 2.8 0.28 11.2 0.1 2.9 3 0 0 3 3 2 1 Helicase HerA, central domain AAA_24 PF13479.6 ORX58947.1 - 0.0058 16.4 0.0 0.69 9.6 0.0 2.9 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ORX58947.1 - 0.011 15.0 0.2 0.84 8.8 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_27 PF13514.6 ORX58947.1 - 0.018 14.7 0.0 8.9 5.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 ORX58947.1 - 0.02 14.5 0.0 0.19 11.3 0.0 2.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_7 PF12775.7 ORX58947.1 - 0.021 14.3 0.0 3.9 6.9 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region CLP1_P PF16575.5 ORX58947.1 - 0.027 14.3 0.0 1.9 8.2 0.0 2.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Viral_helicase1 PF01443.18 ORX58947.1 - 0.029 14.1 0.0 0.94 9.2 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 ORX58947.1 - 0.033 14.2 0.1 12 5.9 0.0 3.5 4 0 0 4 4 2 0 AAA domain (dynein-related subfamily) HEAT PF02985.22 ORX58947.1 - 0.035 14.4 0.4 30 5.2 0.1 4.8 6 0 0 6 6 3 0 HEAT repeat FeoB_N PF02421.18 ORX58947.1 - 0.036 13.6 0.3 10 5.6 0.0 3.1 3 0 0 3 3 3 0 Ferrous iron transport protein B Dynamin_N PF00350.23 ORX58947.1 - 0.04 14.0 1.6 1.1 9.2 0.0 2.9 3 0 0 3 3 2 0 Dynamin family PRK PF00485.18 ORX58947.1 - 0.04 13.7 0.0 1.6 8.4 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family Rcd1 PF04078.13 ORX58947.1 - 0.043 13.1 0.6 0.2 11.0 0.1 2.0 1 1 1 2 2 2 0 Cell differentiation family, Rcd1-like Zeta_toxin PF06414.12 ORX58947.1 - 0.049 12.9 0.1 12 5.1 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin IstB_IS21 PF01695.17 ORX58947.1 - 0.071 12.8 0.0 25 4.5 0.0 3.1 4 0 0 4 4 2 0 IstB-like ATP binding protein NTPase_1 PF03266.15 ORX58947.1 - 0.084 12.8 0.2 9.3 6.1 0.1 2.8 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 ORX58947.1 - 0.086 12.9 0.1 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 ORX58947.1 - 0.095 11.3 4.9 4.1 5.9 0.1 3.4 4 0 0 4 4 3 0 AAA domain Roc PF08477.13 ORX58947.1 - 0.1 12.8 0.1 23 5.2 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 ORX58947.1 - 0.41 10.5 5.7 3.1 7.6 0.0 3.6 4 1 0 4 4 2 0 ATPase domain predominantly from Archaea PEMT PF04191.13 ORX58948.1 - 2.5e-33 114.6 2.4 2.5e-33 114.6 2.4 1.9 3 0 0 3 3 3 1 Phospholipid methyltransferase TAF8_C PF10406.9 ORX58949.1 - 3.4e-15 56.3 3.7 3.8e-15 56.2 1.1 2.4 2 0 0 2 2 2 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 ORX58949.1 - 5.7e-11 42.3 0.0 1.4e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain associated Bromo_TP_like PF17027.5 ORX58949.1 - 0.00023 21.3 0.1 0.00077 19.6 0.0 1.8 2 0 0 2 2 2 1 Histone-fold protein TFIID-31kDa PF02291.15 ORX58949.1 - 0.0088 16.1 0.1 0.02 15.0 0.1 1.6 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Halogen_Hydrol PF10112.9 ORX58949.1 - 0.061 13.3 0.2 0.061 13.3 0.2 1.6 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein EF-hand_4 PF12763.7 ORX58950.1 - 3.5e-27 94.4 0.0 1.5e-12 47.4 0.0 2.9 3 0 0 3 3 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 ORX58950.1 - 3.1e-06 27.5 0.0 2e-05 25.0 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain pair UBA PF00627.31 ORX58950.1 - 9.4e-06 25.4 0.2 2.5e-05 24.1 0.2 1.8 1 0 0 1 1 1 1 UBA/TS-N domain ERM PF00769.19 ORX58950.1 - 7.4e-05 22.7 5.9 7.4e-05 22.7 5.9 3.4 3 1 0 3 3 2 1 Ezrin/radixin/moesin family EF-hand_1 PF00036.32 ORX58950.1 - 0.00021 20.6 0.0 0.032 13.8 0.0 2.7 2 0 0 2 2 2 1 EF hand Spc29 PF17082.5 ORX58950.1 - 0.00021 21.2 1.2 0.00055 19.8 1.2 1.7 1 0 0 1 1 1 1 Spindle Pole Component 29 EF-hand_6 PF13405.6 ORX58950.1 - 0.00062 19.5 0.0 0.94 9.6 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain DUF724 PF05266.14 ORX58950.1 - 0.00067 19.5 10.1 0.0028 17.5 9.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF724) GAS PF13851.6 ORX58950.1 - 0.0041 16.5 18.9 0.01 15.2 18.9 1.6 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ORX58950.1 - 0.0053 16.8 14.5 0.011 15.8 14.5 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 ORX58950.1 - 0.0059 14.8 14.8 0.023 12.9 14.6 1.8 1 1 1 2 2 2 1 Septation ring formation regulator, EzrA SHE3 PF17078.5 ORX58950.1 - 0.0099 15.6 11.2 0.02 14.6 11.2 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 EF-hand_8 PF13833.6 ORX58950.1 - 0.14 12.0 0.0 0.47 10.3 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain pair Spc7 PF08317.11 ORX58950.1 - 0.22 10.4 14.8 0.42 9.4 14.8 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Lebercilin PF15619.6 ORX58950.1 - 0.57 9.8 23.0 1.1 8.9 23.0 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Mod_r PF07200.13 ORX58950.1 - 1.1 9.3 20.0 3.8 7.6 20.0 1.9 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein FapA PF03961.13 ORX58950.1 - 1.5 7.4 9.3 2.4 6.7 9.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PRKG1_interact PF15898.5 ORX58950.1 - 1.5 9.8 12.2 7.4 7.5 12.2 2.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain AAA_13 PF13166.6 ORX58950.1 - 2.2 6.8 11.6 4.7 5.7 11.6 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX58950.1 - 2.3 8.7 11.8 0.94 9.9 8.6 1.8 2 0 0 2 2 2 0 AAA domain FAM76 PF16046.5 ORX58950.1 - 3.1 7.1 17.2 0.4 10.0 11.2 2.3 2 0 0 2 2 2 0 FAM76 protein UPF0242 PF06785.11 ORX58950.1 - 4 7.5 16.6 9.9 6.2 16.6 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PI3K_P85_iSH2 PF16454.5 ORX58950.1 - 5.1 6.7 19.2 24 4.5 19.2 2.0 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain V_ATPase_I PF01496.19 ORX58950.1 - 5.6 4.7 10.4 12 3.7 10.4 1.5 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Laminin_II PF06009.12 ORX58950.1 - 6.5 6.8 14.3 5.1 7.1 10.3 2.4 1 1 1 2 2 2 0 Laminin Domain II FemAB PF02388.16 ORX58950.1 - 9.5 5.0 14.5 1.5 7.6 10.0 1.8 1 1 1 2 2 2 0 FemAB family DUF1242 PF06842.12 ORX58951.1 - 2e-16 59.5 2.7 4.4e-16 58.4 2.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1242) bZIP_1 PF00170.21 ORX58952.1 - 5.4e-09 36.0 14.6 1.8e-08 34.4 14.6 1.9 1 1 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 ORX58952.1 - 3.1e-05 23.9 0.1 3.1e-05 23.9 0.1 3.3 2 1 1 3 3 3 1 Transcription factor PAP1 bZIP_2 PF07716.15 ORX58952.1 - 0.0004 20.4 19.1 0.37 10.9 19.1 2.7 1 1 0 1 1 1 1 Basic region leucine zipper TSC22 PF01166.18 ORX58952.1 - 0.11 12.9 2.0 0.37 11.1 1.3 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family bZIP_Maf PF03131.17 ORX58952.1 - 3.5 8.2 14.3 5 7.7 13.5 1.8 1 1 0 1 1 1 0 bZIP Maf transcription factor Mito_carr PF00153.27 ORX58953.1 - 9.9e-74 243.4 0.9 8.6e-26 89.7 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 ORX58953.1 - 5.9e-16 56.8 5.2 3.9e-07 29.1 0.1 5.3 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 ORX58953.1 - 2.5e-15 56.6 6.3 7.2e-05 23.2 0.1 4.5 3 2 2 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 ORX58953.1 - 4e-15 54.4 5.2 1.4e-06 27.7 0.0 5.6 6 0 0 6 6 6 3 EF-hand domain EF-hand_8 PF13833.6 ORX58953.1 - 1.2e-10 41.0 1.2 0.037 13.9 0.0 4.5 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ORX58953.1 - 0.0017 17.8 1.2 0.0049 16.3 0.1 2.4 3 0 0 3 3 3 1 EF hand EF-hand_9 PF14658.6 ORX58953.1 - 0.0019 18.5 0.1 0.12 12.7 0.1 3.4 3 1 0 3 3 3 1 EF-hand domain Pkinase PF00069.25 ORX58954.1 - 7.2e-71 238.6 0.0 1e-70 238.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX58954.1 - 3.2e-33 115.1 0.0 6.5e-33 114.1 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX58954.1 - 8.7e-06 25.2 1.2 0.31 10.3 0.1 3.2 3 0 0 3 3 3 3 Kinase-like APH PF01636.23 ORX58954.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DcpS_C PF11969.8 ORX58955.1 - 4.8e-24 85.0 0.7 5.9e-24 84.7 0.7 1.0 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ORX58955.1 - 2.5e-13 50.6 3.2 4.5e-13 49.7 3.2 1.3 1 1 0 1 1 1 1 HIT domain CwfJ_C_1 PF04677.15 ORX58955.1 - 0.028 14.3 0.8 0.051 13.4 0.8 1.5 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 GalP_UDP_tr_C PF02744.17 ORX58955.1 - 0.068 12.9 0.0 0.083 12.6 0.0 1.1 1 0 0 1 1 1 0 Galactose-1-phosphate uridyl transferase, C-terminal domain 4F5 PF04419.14 ORX58957.1 - 4e-07 30.8 10.6 6.3e-07 30.2 10.6 1.3 1 0 0 1 1 1 1 4F5 protein family zf-met2 PF12907.7 ORX58957.1 - 0.00078 19.5 1.5 0.0024 18.0 1.5 1.8 1 1 0 1 1 1 1 Zinc-binding zf-Di19 PF05605.12 ORX58957.1 - 0.0013 19.0 0.2 0.002 18.4 0.2 1.3 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ORX58957.1 - 0.043 14.7 0.3 0.074 13.9 0.3 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger Sel_put PF04328.13 ORX58957.1 - 0.061 13.4 1.0 0.1 12.6 0.0 1.8 2 0 0 2 2 2 0 Selenoprotein, putative DUF1644 PF07800.12 ORX58957.1 - 0.14 12.3 1.6 0.24 11.4 1.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) zf-C2H2_6 PF13912.6 ORX58957.1 - 0.2 11.7 1.1 0.21 11.7 0.1 1.6 2 0 0 2 2 2 0 C2H2-type zinc finger Tim54 PF11711.8 ORX58958.1 - 4.3e-56 190.3 0.1 4.9e-56 190.1 0.1 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 PIN_12 PF16289.5 ORX58958.1 - 0.075 13.5 0.5 0.16 12.4 0.4 1.4 1 1 0 1 1 1 0 PIN domain ATP-synt_E PF05680.12 ORX58958.1 - 0.26 11.6 8.2 0.047 14.0 2.7 2.4 2 0 0 2 2 2 0 ATP synthase E chain OmpH PF03938.14 ORX58959.1 - 0.12 12.7 7.9 0.19 12.0 2.4 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) KfrA_N PF11740.8 ORX58959.1 - 0.81 10.4 9.0 3.4 8.4 0.1 3.3 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Sugarporin_N PF11471.8 ORX58959.1 - 2.1 8.4 5.3 6 6.9 5.3 1.8 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Mg_trans_NIPA PF05653.14 ORX58960.1 - 1.6e-23 83.3 15.3 1.8e-22 79.8 15.3 1.9 1 1 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ORX58960.1 - 0.00036 20.7 3.5 0.00036 20.7 3.5 3.3 3 1 1 4 4 4 1 EamA-like transporter family DUF4131 PF13567.6 ORX58960.1 - 0.65 9.6 9.5 0.76 9.4 2.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DUF373 PF04123.13 ORX58960.1 - 6.1 6.2 12.5 1.6e+02 1.5 13.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF373) CUE PF02845.16 ORX58961.1 - 1.3e-06 28.0 0.0 2.4e-06 27.2 0.0 1.5 1 0 0 1 1 1 1 CUE domain DnaJ PF00226.31 ORX58963.1 - 6.1e-14 51.9 0.8 9.9e-14 51.2 0.8 1.4 1 0 0 1 1 1 1 DnaJ domain GFA PF04828.14 ORX58965.1 - 5.7e-08 33.0 1.0 5.7e-08 33.0 1.0 1.6 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Lyase_1 PF00206.20 ORX58966.1 - 4.4e-119 397.5 0.0 5.5e-119 397.2 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ORX58966.1 - 3.6e-24 84.9 0.0 8.3e-24 83.8 0.0 1.7 1 0 0 1 1 1 1 Fumarase C C-terminus YIF1 PF03878.15 ORX58967.1 - 6.3e-86 287.8 3.5 7.1e-86 287.6 3.5 1.0 1 0 0 1 1 1 1 YIF1 GDI PF00996.18 ORX58968.1 - 9.2e-54 182.6 0.0 1.3e-39 136.0 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor SR-25 PF10500.9 ORX58969.1 - 0.13 11.9 11.5 0.19 11.3 11.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Jak1_Phl PF17887.1 ORX58969.1 - 0.13 12.2 1.5 0.23 11.4 1.5 1.3 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Ndc1_Nup PF09531.10 ORX58969.1 - 0.45 9.1 9.3 0.58 8.8 9.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4551 PF15087.6 ORX58969.1 - 8.1 5.1 8.3 12 4.6 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) FAD_binding_1 PF00667.20 ORX58970.1 - 2.3e-58 197.4 0.0 3.4e-58 196.8 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX58970.1 - 1.3e-35 122.7 0.3 2.7e-35 121.7 0.3 1.6 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX58970.1 - 1.3e-18 67.6 0.0 5.3e-18 65.7 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Glyco_tran_WecB PF03808.13 ORX58970.1 - 0.097 12.6 0.0 0.66 9.9 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase WecB/TagA/CpsF family Oxidored-like PF09791.9 ORX58971.1 - 1.8e-07 30.7 6.3 3.1e-07 29.9 6.3 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Synaptobrevin PF00957.21 ORX58972.1 - 3.4e-26 90.9 0.4 4.1e-26 90.6 0.4 1.0 1 0 0 1 1 1 1 Synaptobrevin Beach PF02138.18 ORX58974.1 - 4.8e-122 406.6 0.1 8.2e-122 405.9 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ORX58974.1 - 1e-09 38.4 0.0 4.2e-09 36.4 0.0 2.2 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH FYVE PF01363.21 ORX58974.1 - 1.1e-09 38.2 11.9 2.1e-09 37.4 11.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger WD40 PF00400.32 ORX58974.1 - 1.5e-09 38.3 9.3 5.7e-05 23.8 0.3 5.1 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF4704 PF15787.5 ORX58974.1 - 1.6e-07 30.9 3.7 1.6e-07 30.9 3.7 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4704) DHDPS PF00701.22 ORX58976.1 - 1.7e-49 168.1 0.0 2.1e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Type_III_YscG PF09477.10 ORX58976.1 - 0.076 13.1 0.0 0.18 11.9 0.0 1.6 1 0 0 1 1 1 0 Bacterial type II secretion system chaperone protein (type_III_yscG) WD40 PF00400.32 ORX58977.1 - 1.3e-13 51.2 12.8 4.1e-06 27.4 0.1 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 ORX58977.1 - 1.9e-10 40.9 0.0 1.9e-09 37.6 0.0 2.4 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 ORX58977.1 - 3.5e-06 27.2 2.6 0.011 16.0 0.5 3.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX58977.1 - 4.8e-05 23.3 0.2 0.0043 17.0 0.1 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A HEAT PF02985.22 ORX58978.1 - 2.4e-19 67.7 11.5 2.5e-05 24.1 0.0 10.4 12 0 0 12 12 12 3 HEAT repeat HEAT_EZ PF13513.6 ORX58978.1 - 1.6e-15 57.2 8.4 4.4e-09 36.7 0.0 8.3 8 1 1 9 9 9 2 HEAT-like repeat HEAT_2 PF13646.6 ORX58978.1 - 4.5e-10 39.8 7.7 0.00026 21.3 0.0 7.5 3 2 7 10 10 10 2 HEAT repeats IBN_N PF03810.19 ORX58978.1 - 1.2e-09 38.0 0.1 3.9e-09 36.3 0.1 2.0 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cnd1 PF12717.7 ORX58978.1 - 1e-06 28.9 3.9 6.5e-06 26.3 0.0 3.8 3 2 4 7 7 7 1 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 ORX58978.1 - 8.9e-06 25.6 0.9 3.3 7.4 0.0 4.6 3 1 1 4 4 4 1 rRNA processing/ribosome biogenesis Arm PF00514.23 ORX58978.1 - 0.00023 21.1 6.2 1.3 9.2 0.1 5.2 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat TIP120 PF08623.10 ORX58978.1 - 0.00045 20.0 1.8 0.87 9.3 0.0 3.9 2 1 1 3 3 3 2 TATA-binding protein interacting (TIP20) Tti2 PF10521.9 ORX58978.1 - 0.01 15.4 0.6 0.51 9.8 0.0 3.5 3 1 1 4 4 4 0 Tti2 family Sedlin_N PF04628.13 ORX58979.1 - 2.9e-46 156.8 1.8 3.2e-46 156.7 1.8 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 ORX58979.1 - 3.1e-08 33.7 0.8 4.6e-08 33.1 0.6 1.4 1 1 0 1 1 1 1 Sybindin-like family MFS_1 PF07690.16 ORX58980.1 - 1.2e-24 86.9 45.7 1.5e-13 50.5 19.9 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX58980.1 - 3.5e-05 22.9 13.2 3.5e-05 22.9 13.2 3.2 1 1 2 3 3 3 2 Sugar (and other) transporter Pex14_N PF04695.13 ORX58981.1 - 1.3e-23 84.3 23.5 2.5e-23 83.5 18.6 2.7 2 1 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TGBp3 PF02495.17 ORX58983.1 - 0.24 11.1 3.8 0.095 12.4 1.7 1.5 2 0 0 2 2 2 0 Triple gene block 3 Ribosomal_L3 PF00297.22 ORX58984.1 - 1.5e-159 530.9 9.5 1.7e-159 530.8 9.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 FadA PF09403.10 ORX58984.1 - 0.12 12.9 0.7 0.25 11.8 0.7 1.5 1 0 0 1 1 1 0 Adhesion protein FadA Tho1_MOS11_C PF18592.1 ORX58984.1 - 0.25 11.2 1.5 1.1 9.1 0.3 2.5 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain V-ATPase_G PF03179.15 ORX58985.1 - 7.2e-32 110.1 15.9 8.2e-32 109.9 15.9 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF2252 PF10009.9 ORX58985.1 - 0.0074 15.4 5.4 0.0081 15.3 5.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2252) Mst1_SARAH PF11629.8 ORX58985.1 - 0.013 15.5 0.8 0.062 13.4 0.0 2.2 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 ATP-synt_B PF00430.18 ORX58985.1 - 0.035 14.2 11.2 0.035 14.2 11.2 2.0 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) DUF899 PF05988.12 ORX58985.1 - 0.039 13.5 0.0 0.044 13.3 0.0 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) CemA PF03040.14 ORX58985.1 - 0.054 13.4 5.4 0.063 13.2 5.4 1.1 1 0 0 1 1 1 0 CemA family V-ATPase_G_2 PF16999.5 ORX58985.1 - 0.063 13.7 17.2 0.14 12.6 17.2 1.6 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit PIN_8 PF18476.1 ORX58985.1 - 0.085 12.7 7.7 0.094 12.6 7.7 1.1 1 0 0 1 1 1 0 PIN like domain TnpV PF14198.6 ORX58985.1 - 0.11 12.5 5.5 0.031 14.2 1.9 1.8 1 1 1 2 2 2 0 Transposon-encoded protein TnpV Muted PF14942.6 ORX58985.1 - 0.17 12.3 12.1 0.4 11.0 12.1 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF3500 PF12006.8 ORX58985.1 - 0.22 11.0 3.0 0.26 10.7 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) MPM1 PF17234.2 ORX58985.1 - 0.23 11.7 5.2 0.27 11.5 5.2 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 Lipoprotein_3 PF00938.17 ORX58985.1 - 0.25 11.6 3.9 0.54 10.5 0.5 2.2 1 1 1 2 2 2 0 Lipoprotein DUF883 PF05957.13 ORX58985.1 - 0.25 12.0 11.1 0.29 11.7 2.3 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) 5_nucleotid PF05761.14 ORX58985.1 - 0.26 10.2 6.6 0.3 10.0 6.6 1.0 1 0 0 1 1 1 0 5' nucleotidase family DUF1690 PF07956.11 ORX58985.1 - 0.58 10.6 11.5 0.73 10.3 11.5 1.1 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF3450 PF11932.8 ORX58985.1 - 0.66 9.2 12.7 1.2 8.4 12.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Prominin PF05478.11 ORX58985.1 - 0.86 7.5 5.6 0.91 7.4 5.6 1.0 1 0 0 1 1 1 0 Prominin ZYG-11_interact PF05884.12 ORX58985.1 - 0.87 8.9 3.5 1.1 8.6 3.5 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 ATP11 PF06644.11 ORX58985.1 - 1.2 8.9 9.4 1.4 8.6 9.4 1.1 1 0 0 1 1 1 0 ATP11 protein Seryl_tRNA_N PF02403.22 ORX58985.1 - 1.2 9.4 13.9 2 8.7 13.8 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PEP-utilisers_N PF05524.13 ORX58985.1 - 1.3 9.2 10.4 5.6 7.2 10.4 1.9 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF4407 PF14362.6 ORX58985.1 - 2.9 7.1 8.9 3.8 6.8 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ORX58985.1 - 3.4 6.8 5.3 4 6.6 5.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein R-HINP1I PF11463.8 ORX58986.1 - 0.11 11.9 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 R.HinP1I restriction endonuclease Med9 PF07544.13 ORX58986.1 - 0.12 12.5 3.5 0.25 11.4 2.2 2.1 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 HR1 PF02185.16 ORX58986.1 - 0.43 10.7 6.6 6.2 7.0 6.6 2.3 1 1 0 1 1 1 0 Hr1 repeat Enkurin PF13864.6 ORX58986.1 - 0.46 11.0 4.9 0.49 10.8 0.3 2.6 1 1 1 2 2 2 0 Calmodulin-binding SlyX PF04102.12 ORX58986.1 - 6.4 7.5 10.8 0.41 11.3 1.8 3.0 2 1 1 3 3 3 0 SlyX Zn_clus PF00172.18 ORX58987.1 - 9.7e-06 25.6 13.1 1.7e-05 24.8 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain E1_dh PF00676.20 ORX58988.1 - 2.4e-93 312.4 0.8 2.7e-93 312.2 0.8 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ORX58988.1 - 0.0006 19.1 0.1 0.0037 16.5 0.0 2.1 2 1 0 3 3 3 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ORX58988.1 - 0.003 17.4 1.5 0.0092 15.8 0.2 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Ndc80_HEC PF03801.13 ORX58988.1 - 0.027 14.1 0.4 0.044 13.4 0.4 1.4 1 0 0 1 1 1 0 HEC/Ndc80p family GPI-anchored PF10342.9 ORX58989.1 - 7.5e-14 52.3 3.1 7.5e-14 52.3 3.1 1.9 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF515 PF04415.12 ORX58989.1 - 0.01 14.3 6.9 0.014 13.8 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Sporozoite_P67 PF05642.11 ORX58989.1 - 1.4 7.0 9.5 1.5 6.8 9.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RAP1 PF07218.11 ORX58989.1 - 4.6 5.4 7.1 4.5 5.4 7.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CCDC24 PF15669.5 ORX58989.1 - 7.1 6.4 6.1 10 5.9 6.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family Glyco_transf_21 PF13506.6 ORX58991.1 - 2.6e-44 150.7 0.1 3.9e-44 150.2 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 ORX58991.1 - 1.2e-24 87.5 0.0 1.6e-24 87.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 ORX58991.1 - 1.2e-12 48.2 4.0 2e-12 47.5 4.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 ORX58991.1 - 4.3e-05 23.4 0.0 7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 GET2 PF08690.10 ORX58991.1 - 0.43 10.2 3.1 0.7 9.5 3.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 FHA_2 PF17913.1 ORX58992.1 - 0.0015 18.7 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 FHA domain FHA PF00498.26 ORX58992.1 - 0.0062 16.9 0.0 0.0098 16.2 0.0 1.3 1 0 0 1 1 1 1 FHA domain adh_short_C2 PF13561.6 ORX58993.1 - 2.1e-51 174.7 3.5 2.7e-51 174.4 3.5 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX58993.1 - 1.8e-42 145.0 1.6 2.5e-42 144.6 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX58993.1 - 4.9e-07 29.8 2.1 2.9e-06 27.3 2.1 1.9 1 1 0 1 1 1 1 KR domain Met_asp_mut_E PF06368.11 ORX58993.1 - 0.016 13.7 0.1 0.021 13.3 0.1 1.1 1 0 0 1 1 1 0 Methylaspartate mutase E chain (MutE) Sacchrp_dh_NADP PF03435.18 ORX58993.1 - 0.022 15.0 0.0 0.046 14.0 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ARD PF03079.14 ORX58994.1 - 1.5e-50 171.4 0.1 1.8e-50 171.2 0.1 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 ORX58994.1 - 6.3e-11 41.8 0.0 1.1e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ORX58994.1 - 3.2e-07 30.3 0.0 5.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ORX58994.1 - 0.00042 20.0 0.0 0.00063 19.4 0.0 1.2 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 ORX58994.1 - 0.04 13.6 0.0 0.065 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF861) Cupin_8 PF13621.6 ORX58994.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Cupin-like domain Vps35 PF03635.17 ORX58995.1 - 0 1011.3 1.2 0 1011.1 1.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 DUF2486 PF10667.9 ORX58995.1 - 1.1 9.4 14.2 2 8.6 14.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) Striatin PF08232.12 ORX58995.1 - 7.2 7.2 9.1 2.9 8.5 0.2 2.6 2 0 0 2 2 2 0 Striatin family SURF2 PF05477.11 ORX58995.1 - 9.3 5.9 7.5 17 5.0 7.5 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) LIM PF00412.22 ORX58996.1 - 2.6e-24 85.2 21.0 1.4e-12 47.6 4.0 2.3 2 0 0 2 2 2 2 LIM domain zf_UBZ PF18439.1 ORX58996.1 - 0.012 15.2 12.5 8 6.2 0.0 4.8 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger DUF4666 PF15697.5 ORX58996.1 - 0.24 12.1 4.3 0.46 11.2 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) zf-ACC PF17848.1 ORX58996.1 - 0.46 10.6 0.1 0.46 10.6 0.1 4.3 4 0 0 4 4 4 0 Acetyl-coA carboxylase zinc finger domain E6 PF00518.17 ORX58996.1 - 2.5 8.6 10.1 0.55 10.7 0.7 3.3 2 1 1 3 3 3 0 Early Protein (E6) PEHE PF15275.6 ORX58996.1 - 2.8 8.6 13.5 6.8 7.3 13.5 1.6 1 1 0 1 1 1 0 PEHE domain Zn-ribbon_8 PF09723.10 ORX58996.1 - 5.5 7.2 17.3 14 5.9 0.6 4.3 4 0 0 4 4 4 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 ORX58997.1 - 0.00075 19.7 3.2 0.0058 16.9 0.8 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ORX58997.1 - 0.0009 19.5 4.0 0.74 10.2 0.1 3.4 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ORX58997.1 - 0.0012 19.1 10.0 0.015 15.7 0.6 3.3 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ORX58997.1 - 0.005 17.2 1.2 0.005 17.2 1.2 4.1 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX58997.1 - 0.009 16.4 13.4 0.11 13.0 0.3 4.6 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX58997.1 - 0.015 16.1 1.3 0.015 16.1 1.3 4.8 5 0 0 5 5 5 0 C2H2-type zinc finger Activator_LAG-3 PF11498.8 ORX58997.1 - 0.018 14.1 7.3 0.028 13.4 7.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FOXP-CC PF16159.5 ORX58997.1 - 0.05 14.2 0.1 0.05 14.2 0.1 3.8 3 2 1 4 4 4 0 FOXP coiled-coil domain zf_ZIC PF18366.1 ORX58997.1 - 6.7 6.9 5.8 16 5.7 0.0 3.1 3 0 0 3 3 3 0 Zic proteins zinc finger domain zf-C2H2_3rep PF18868.1 ORX58997.1 - 7.4 7.3 7.7 8.2 7.1 0.1 3.1 3 1 1 4 4 4 0 Zinc finger C2H2-type, 3 repeats zf-HIT PF04438.16 ORX58998.1 - 3.7e-10 39.5 12.4 3.7e-10 39.5 12.4 1.9 2 0 0 2 2 2 1 HIT zinc finger zf-C2H2_11 PF16622.5 ORX58998.1 - 0.26 11.1 7.4 0.19 11.5 5.0 2.1 1 1 0 1 1 1 0 zinc-finger C2H2-type zf-MYND PF01753.18 ORX58998.1 - 1 9.5 13.4 2.3 8.4 13.4 1.6 1 0 0 1 1 1 0 MYND finger Helicase_C PF00271.31 ORX58999.1 - 5.7e-21 74.9 0.0 1.4e-20 73.6 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX58999.1 - 3.2e-18 66.3 0.0 6.7e-18 65.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX58999.1 - 6.2e-17 61.9 0.0 1.5e-16 60.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AMP-binding PF00501.28 ORX59000.1 - 6.6e-60 202.9 0.0 9e-51 172.8 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ORX59000.1 - 2.2e-15 57.3 0.0 4.1e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Cyclophil_like2 PF18050.1 ORX59000.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Cyclophilin-like family RPE65 PF03055.15 ORX59001.1 - 9.4e-82 275.6 0.7 1.2e-81 275.2 0.7 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein Ribosomal_S8 PF00410.19 ORX59002.1 - 1.4e-22 80.0 0.0 1.8e-22 79.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 LAGLIDADG_WhiA PF14527.6 ORX59002.1 - 0.14 12.2 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain TFIIIC_delta PF12657.7 ORX59003.1 - 3.9e-11 43.2 0.4 1.6e-10 41.2 0.4 2.1 1 1 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 ORX59003.1 - 1.3e-08 34.7 3.9 1.3e-08 34.7 3.9 1.8 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex Sec34 PF04136.15 ORX59004.1 - 5.6e-49 165.9 7.7 1.5e-48 164.4 3.9 2.6 1 1 1 2 2 2 1 Sec34-like family Sigma70_ner PF04546.13 ORX59004.1 - 0.069 13.0 0.0 0.2 11.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, non-essential region Occludin_ELL PF07303.13 ORX59004.1 - 0.39 11.5 4.0 5.7 7.7 0.1 3.2 2 1 1 3 3 3 0 Occludin homology domain Pil1 PF13805.6 ORX59006.1 - 4.6e-39 134.5 5.7 8e-39 133.7 5.7 1.4 1 0 0 1 1 1 1 Eisosome component PIL1 TMPIT PF07851.13 ORX59006.1 - 0.48 9.6 2.3 0.98 8.6 2.3 1.5 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 ORX59006.1 - 1.7 9.2 14.8 0.41 11.2 3.6 2.9 3 0 0 3 3 3 0 Apg6 coiled-coil region KELK PF15796.5 ORX59006.1 - 1.9 9.0 8.7 19 5.8 4.0 2.9 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MAT1 PF06391.13 ORX59006.1 - 6.1 6.6 19.6 0.034 14.0 8.7 2.8 3 1 0 3 3 3 0 CDK-activating kinase assembly factor MAT1 Methyltransf_25 PF13649.6 ORX59007.1 - 4.2e-12 46.6 0.0 9.2e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX59007.1 - 1e-10 42.1 0.0 2.1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX59007.1 - 1.6e-06 28.1 0.0 2.5e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX59007.1 - 3.6e-06 26.6 0.0 0.00015 21.2 0.0 2.6 2 1 1 3 3 3 1 Putative methyltransferase Methyltransf_31 PF13847.6 ORX59007.1 - 4.2e-05 23.4 0.0 0.00013 21.8 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 ORX59007.1 - 0.00011 22.1 0.0 0.00015 21.7 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_12 PF08242.12 ORX59007.1 - 0.00012 22.8 0.0 0.00021 22.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ORX59007.1 - 0.051 13.7 0.0 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 FtsJ-like methyltransferase p450 PF00067.22 ORX59008.1 - 2.5e-36 125.4 0.0 5.2e-36 124.4 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Prefoldin_2 PF01920.20 ORX59009.1 - 2.4e-21 75.7 6.8 3.2e-19 68.8 0.1 2.1 2 0 0 2 2 2 2 Prefoldin subunit ATPase PF06745.13 ORX59009.1 - 0.0039 16.6 0.0 0.0058 16.0 0.0 1.2 1 0 0 1 1 1 1 KaiC TPR_MLP1_2 PF07926.12 ORX59009.1 - 0.019 15.0 0.4 0.019 15.0 0.4 1.9 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DASH_Dad3 PF08656.10 ORX59009.1 - 0.023 14.7 0.9 0.048 13.7 0.1 1.8 2 0 0 2 2 2 0 DASH complex subunit Dad3 DUF5595 PF18077.1 ORX59009.1 - 0.052 13.6 2.9 2.6 8.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) DUF5460 PF17544.2 ORX59009.1 - 0.071 12.1 0.0 0.089 11.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5460) TMF_DNA_bd PF12329.8 ORX59009.1 - 0.092 12.8 1.1 0.092 12.8 1.1 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding OmpH PF03938.14 ORX59009.1 - 0.33 11.3 7.4 0.4 11.0 0.5 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tropomyosin_1 PF12718.7 ORX59009.1 - 0.53 10.4 6.0 0.26 11.4 1.1 2.1 2 0 0 2 2 2 0 Tropomyosin like DivIC PF04977.15 ORX59009.1 - 2.5 7.9 7.7 0.19 11.5 1.0 2.0 2 0 0 2 2 2 0 Septum formation initiator FAA_hydrolase PF01557.18 ORX59010.1 - 8.5e-59 198.9 0.0 1.1e-58 198.4 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ORX59010.1 - 2.1e-37 127.6 0.0 4e-37 126.7 0.0 1.5 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal MspA PF09203.11 ORX59010.1 - 0.11 12.3 0.0 6.2 6.6 0.0 2.4 2 1 0 2 2 2 0 MspA AAA_11 PF13086.6 ORX59011.1 - 5.4e-65 219.8 0.4 1.3e-64 218.6 0.4 1.7 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ORX59011.1 - 8e-55 185.6 0.0 1.4e-53 181.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX59011.1 - 6.2e-16 58.7 0.1 6.4e-15 55.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX59011.1 - 4.8e-11 43.2 0.0 1.7e-10 41.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ORX59011.1 - 2.8e-10 40.3 0.1 0.01 15.6 0.0 3.8 4 0 0 4 4 4 3 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ORX59011.1 - 3.5e-08 33.1 0.4 0.011 15.0 0.0 3.1 3 0 0 3 3 3 2 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 ORX59011.1 - 2.3e-07 31.0 0.0 6.1e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ORX59011.1 - 4.8e-06 26.9 0.6 0.00014 22.1 0.3 3.1 2 1 0 2 2 1 1 AAA domain PhoH PF02562.16 ORX59011.1 - 2e-05 24.2 0.1 0.00014 21.4 0.1 2.1 1 1 0 1 1 1 1 PhoH-like protein Helicase_RecD PF05127.14 ORX59011.1 - 2.1e-05 24.5 0.1 0.0015 18.5 0.1 2.4 1 1 0 1 1 1 1 Helicase PIF1 PF05970.14 ORX59011.1 - 0.00029 20.1 0.0 0.057 12.6 0.0 2.4 2 0 0 2 2 2 1 PIF1-like helicase DEAD PF00270.29 ORX59011.1 - 0.00042 20.1 0.2 0.012 15.4 0.2 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA PF00004.29 ORX59011.1 - 0.00063 20.2 0.6 0.0039 17.6 0.0 2.6 2 1 1 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX59011.1 - 0.00076 19.9 0.2 0.0034 17.8 0.0 2.2 1 1 0 2 2 1 1 AAA ATPase domain UvrD-helicase PF00580.21 ORX59011.1 - 0.00089 18.9 0.0 0.0067 16.0 0.0 1.8 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C_2 PF13538.6 ORX59011.1 - 0.004 16.9 0.5 0.029 14.2 0.0 2.5 3 0 0 3 3 2 1 UvrD-like helicase C-terminal domain T2SSE PF00437.20 ORX59011.1 - 0.0041 16.2 0.1 0.016 14.3 0.0 2.0 3 0 0 3 3 3 1 Type II/IV secretion system protein IstB_IS21 PF01695.17 ORX59011.1 - 0.0066 16.2 0.1 0.029 14.1 0.0 2.1 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_25 PF13481.6 ORX59011.1 - 0.0089 15.6 2.5 0.48 10.0 0.0 3.4 2 1 1 3 3 3 1 AAA domain SKI PF01202.22 ORX59011.1 - 0.012 15.7 0.2 0.076 13.1 0.0 2.3 2 0 0 2 2 2 0 Shikimate kinase AAA_5 PF07728.14 ORX59011.1 - 0.016 15.2 0.0 0.066 13.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ORX59011.1 - 0.024 14.4 0.1 0.18 11.5 0.0 2.5 2 1 0 2 2 2 0 AAA domain DnaB_C PF03796.15 ORX59011.1 - 0.035 13.4 0.0 0.082 12.2 0.0 1.5 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain Flavi_DEAD PF07652.14 ORX59011.1 - 0.037 14.0 0.1 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 Flavivirus DEAD domain NACHT PF05729.12 ORX59011.1 - 0.037 13.9 0.0 0.14 12.0 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Herpes_ori_bp PF02399.15 ORX59011.1 - 0.042 11.9 0.0 0.065 11.3 0.0 1.3 1 0 0 1 1 1 0 Origin of replication binding protein FtsK_SpoIIIE PF01580.18 ORX59011.1 - 0.06 12.7 0.3 0.95 8.8 0.3 2.3 1 1 0 1 1 1 0 FtsK/SpoIIIE family ATPase_2 PF01637.18 ORX59011.1 - 0.073 13.0 0.1 0.25 11.2 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ORX59011.1 - 0.078 13.1 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain UvrD_C PF13361.6 ORX59011.1 - 0.085 12.2 0.1 0.38 10.1 0.0 2.0 2 1 0 2 2 2 0 UvrD-like helicase C-terminal domain TK PF00265.18 ORX59011.1 - 0.11 12.4 0.2 6.3 6.6 0.0 2.5 1 1 1 2 2 2 0 Thymidine kinase ABC_tran PF00005.27 ORX59011.1 - 0.12 12.9 0.2 0.65 10.5 0.1 2.5 2 1 0 2 2 1 0 ABC transporter AAA_14 PF13173.6 ORX59011.1 - 0.15 12.1 0.0 0.97 9.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Trans_reg_C PF00486.28 ORX59011.1 - 0.22 11.6 2.5 2.4 8.3 0.7 3.0 2 1 1 3 3 3 0 Transcriptional regulatory protein, C terminal Polysacc_deac_1 PF01522.21 ORX59012.1 - 1.2e-08 34.9 0.1 3e-08 33.6 0.1 1.7 1 1 0 1 1 1 1 Polysaccharide deacetylase Nuc_deoxyri_tr2 PF15891.5 ORX59012.1 - 0.11 12.9 0.0 1.8 8.9 0.0 2.2 2 0 0 2 2 2 0 Nucleoside 2-deoxyribosyltransferase like Nup54 PF13874.6 ORX59013.1 - 1.4e-32 112.7 5.0 1.4e-32 112.7 5.0 1.7 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 ORX59013.1 - 0.0013 18.6 0.0 0.0046 16.8 0.0 1.9 1 0 0 1 1 1 1 Nup54 C-terminal interacting domain Nucleoporin_FG PF13634.6 ORX59013.1 - 0.0032 18.3 27.1 0.019 15.8 27.1 2.0 1 1 0 1 1 1 1 Nucleoporin FG repeat region Unstab_antitox PF09720.10 ORX59013.1 - 0.065 13.3 0.8 1.4 9.0 0.1 2.9 3 0 0 3 3 3 0 Putative addiction module component Cas_DxTHG PF09455.10 ORX59013.1 - 0.28 10.7 4.8 0.36 10.4 4.8 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family SAE2 PF08573.10 ORX59013.1 - 0.35 12.0 3.3 10 7.3 0.1 2.4 2 0 0 2 2 2 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DIL PF01843.19 ORX59013.1 - 3.8 7.8 6.7 0.8 10.0 1.2 2.3 2 1 0 2 2 2 0 DIL domain Rap_GAP PF02145.15 ORX59016.1 - 5.3e-51 172.8 0.0 7.1e-51 172.4 0.0 1.1 1 0 0 1 1 1 1 Rap/ran-GAP RNase_HII PF01351.18 ORX59017.1 - 2.2e-54 184.3 0.0 3e-54 183.9 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease HII DUF5321 PF17254.2 ORX59018.1 - 3.5e-07 29.8 0.0 5.4e-07 29.2 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5321) Sec7 PF01369.20 ORX59019.1 - 4.4e-66 222.1 2.2 7.7e-66 221.3 2.2 1.4 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ORX59019.1 - 3.3e-17 62.8 1.1 3.3e-17 62.8 1.1 2.8 3 1 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF4286 PF14114.6 ORX59020.1 - 0.11 13.0 0.7 0.27 11.7 0.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4286) DUF4150 PF13665.6 ORX59021.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4150) CBFD_NFYB_HMF PF00808.23 ORX59022.1 - 7.4e-12 45.4 0.0 1.2e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX59022.1 - 0.0057 17.0 0.0 0.0057 17.0 0.0 2.2 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CNDH2_C PF16858.5 ORX59022.1 - 0.011 15.6 6.8 0.012 15.5 6.8 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Cwf_Cwc_15 PF04889.12 ORX59022.1 - 0.013 15.3 11.5 0.014 15.1 11.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TAFII28 PF04719.14 ORX59022.1 - 0.016 15.3 0.2 0.025 14.7 0.2 1.3 1 1 0 1 1 1 0 hTAFII28-like protein conserved region DASH_Spc19 PF08287.11 ORX59022.1 - 0.037 13.9 7.9 0.05 13.5 7.9 1.1 1 0 0 1 1 1 0 Spc19 DUF4746 PF15928.5 ORX59022.1 - 0.083 12.3 5.2 0.1 12.0 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NPR3 PF03666.13 ORX59022.1 - 0.14 10.9 5.1 0.16 10.7 5.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 UPF0565 PF10561.9 ORX59022.1 - 0.15 11.3 1.3 0.18 11.0 1.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF2201_N PF13203.6 ORX59022.1 - 0.22 11.1 4.4 0.28 10.8 4.4 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF4770 PF15994.5 ORX59022.1 - 0.29 11.3 6.1 0.35 11.1 5.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4770) Vfa1 PF08432.10 ORX59022.1 - 0.38 11.0 11.6 0.5 10.7 11.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 ORX59022.1 - 0.48 9.4 5.0 0.6 9.0 5.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ORX59022.1 - 0.56 8.7 5.1 0.67 8.4 5.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 ORX59022.1 - 0.8 8.9 2.2 0.9 8.7 2.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 ORX59022.1 - 0.93 9.9 7.2 5 7.6 7.2 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 RP-C_C PF11800.8 ORX59022.1 - 0.93 9.6 7.3 1.2 9.1 7.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region TAF4 PF05236.14 ORX59022.1 - 1.2 8.8 14.4 2 8.1 14.3 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Presenilin PF01080.17 ORX59022.1 - 1.2 7.8 4.8 1.4 7.6 4.8 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 ORX59022.1 - 1.8 6.3 5.1 2 6.2 5.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TCTP PF00838.17 ORX59022.1 - 2.9 8.2 8.6 0.096 13.0 1.4 1.8 1 1 1 2 2 2 0 Translationally controlled tumour protein MFS_1_like PF12832.7 ORX59023.1 - 7.3e-63 212.7 18.5 8.7e-63 212.5 18.5 1.0 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ORX59023.1 - 1.1e-18 67.3 42.5 5.1e-11 42.1 22.2 3.1 1 1 2 3 3 3 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 ORX59023.1 - 1.5e-09 37.4 17.5 1.1e-08 34.5 5.5 2.3 2 1 0 2 2 2 2 Nucleoside H+ symporter LacY_symp PF01306.19 ORX59023.1 - 1.6e-08 33.8 5.8 1.6e-08 33.8 5.8 2.1 2 0 0 2 2 2 1 LacY proton/sugar symporter ANAPC3 PF12895.7 ORX59024.1 - 7.9e-16 58.1 19.0 1.2e-08 35.1 4.5 6.2 5 2 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ORX59024.1 - 1e-15 58.0 35.7 0.018 15.5 1.5 7.9 6 2 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ORX59024.1 - 7.6e-15 54.3 23.1 0.078 13.8 0.1 9.9 6 3 4 10 10 10 4 Tetratricopeptide repeat SRP72 PF08492.12 ORX59024.1 - 2.3e-14 53.5 8.2 2.3e-14 53.5 8.2 3.0 3 0 0 3 3 3 1 SRP72 RNA-binding domain SRP_TPR_like PF17004.5 ORX59024.1 - 2.4e-14 53.4 3.0 2.4e-14 53.4 3.0 2.9 3 0 0 3 3 2 1 Putative TPR-like repeat TPR_8 PF13181.6 ORX59024.1 - 1.8e-11 43.3 11.7 0.21 11.9 0.5 7.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ORX59024.1 - 2.3e-11 43.6 28.3 0.069 13.8 0.3 10.6 9 1 1 10 10 10 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX59024.1 - 3.2e-11 42.4 22.5 0.0036 17.3 0.5 7.9 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX59024.1 - 2.7e-09 37.2 24.4 0.0012 19.1 0.4 7.0 6 4 2 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX59024.1 - 4.7e-09 35.7 14.0 0.021 14.7 0.4 6.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX59024.1 - 8e-07 28.7 11.3 0.033 14.2 0.2 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX59024.1 - 6.7e-05 23.5 26.9 0.16 12.6 0.6 6.8 6 1 2 8 8 8 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX59024.1 - 0.00018 21.6 14.4 2.3 8.4 0.1 6.1 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX59024.1 - 0.00083 19.6 14.1 3.1 8.4 0.1 6.2 6 0 0 6 6 5 1 Tetratricopeptide repeat SNAP PF14938.6 ORX59024.1 - 0.005 16.3 0.2 0.005 16.3 0.2 3.8 3 1 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ORX59024.1 - 0.0054 16.7 20.0 0.48 10.5 1.5 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX59024.1 - 0.0092 15.6 19.3 0.13 12.0 1.1 5.6 6 0 0 6 6 6 2 TPR repeat BTAD PF03704.17 ORX59024.1 - 0.059 13.8 0.0 0.059 13.8 0.0 5.0 3 2 1 5 5 5 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 ORX59024.1 - 0.32 10.9 15.8 14 5.7 0.3 6.4 8 0 0 8 8 8 0 Tetratricopeptide repeat SgrR_N PF12793.7 ORX59024.1 - 1.1 9.5 4.1 2.7 8.2 0.0 3.6 4 0 0 4 4 4 0 Sugar transport-related sRNA regulator N-term Ribosomal_L22 PF00237.19 ORX59024.1 - 1.3 9.3 5.0 1.6 9.0 2.1 2.6 2 1 0 2 2 2 0 Ribosomal protein L22p/L17e TPR_4 PF07721.14 ORX59024.1 - 1.4 9.8 0.0 1.4 9.8 0.0 6.8 9 0 0 9 9 6 0 Tetratricopeptide repeat TPR_20 PF14561.6 ORX59024.1 - 5.7 7.4 24.2 1.6 9.1 0.0 6.4 6 1 1 7 7 7 0 Tetratricopeptide repeat Formyl_trans_N PF00551.19 ORX59025.1 - 1.4e-52 178.1 0.1 1.9e-52 177.6 0.1 1.0 1 0 0 1 1 1 1 Formyl transferase DUF2001 PF09393.10 ORX59025.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Phage tail tube protein SnoaL_2 PF12680.7 ORX59025.1 - 0.14 12.8 0.0 0.32 11.7 0.0 1.5 1 0 0 1 1 1 0 SnoaL-like domain Lipase_3 PF01764.25 ORX59026.1 - 2e-13 50.4 0.0 3.8e-13 49.5 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) F_bP_aldolase PF01116.20 ORX59027.1 - 1.1e-88 297.4 0.0 1.2e-88 297.2 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II S-methyl_trans PF02574.16 ORX59027.1 - 0.076 12.8 0.1 4.3 7.1 0.0 2.6 3 0 0 3 3 3 0 Homocysteine S-methyltransferase Lactate_perm PF02652.14 ORX59027.1 - 0.23 10.2 0.0 0.33 9.6 0.0 1.1 1 0 0 1 1 1 0 L-lactate permease IBN_N PF03810.19 ORX59028.1 - 8.9e-19 67.2 0.3 1e-17 63.8 0.1 2.7 2 0 0 2 2 2 1 Importin-beta N-terminal domain Cse1 PF08506.10 ORX59028.1 - 7e-10 38.3 0.1 2.5e-09 36.4 0.1 2.0 1 0 0 1 1 1 1 Cse1 Xpo1 PF08389.12 ORX59028.1 - 0.00061 19.9 2.7 0.007 16.4 0.0 4.1 5 1 0 5 5 5 1 Exportin 1-like protein CagY_I PF14585.6 ORX59029.1 - 0.36 11.0 0.0 0.36 11.0 0.0 2.6 3 0 0 3 3 3 0 CagY type 1 repeat B56 PF01603.20 ORX59030.1 - 9.6e-170 565.0 6.3 4.9e-169 562.7 6.3 1.8 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 ORX59030.1 - 0.12 12.2 3.0 0.93 9.4 0.7 2.5 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Med12 PF09497.10 ORX59031.1 - 1.2e-22 80.0 0.0 3.2e-22 78.6 0.0 1.8 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 ORX59031.1 - 4.2e-06 25.9 3.2 1.1e-05 24.5 1.2 2.5 2 1 0 2 2 2 1 Eukaryotic Mediator 12 subunit domain DUF496 PF04363.12 ORX59031.1 - 0.01 15.9 1.6 1.2 9.2 0.5 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF496) CDT1_C PF16679.5 ORX59031.1 - 0.8 10.2 4.9 1 9.9 2.2 2.7 3 0 0 3 3 3 0 DNA replication factor Cdt1 C-terminal domain Aldo_ket_red PF00248.21 ORX59032.1 - 1.4e-45 155.8 0.0 1.8e-45 155.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Nitro_FeMo-Co PF02579.17 ORX59032.1 - 0.0023 18.2 0.0 0.015 15.6 0.0 2.3 2 0 0 2 2 2 1 Dinitrogenase iron-molybdenum cofactor TPP_enzyme_N PF02776.18 ORX59033.1 - 3.6e-31 108.1 0.0 7.2e-31 107.1 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 ORX59033.1 - 6e-18 65.1 0.0 1.6e-17 63.7 0.0 1.7 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ORX59033.1 - 1.9e-17 63.3 0.0 4.6e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain LSM PF01423.22 ORX59037.1 - 4.2e-22 77.6 0.1 4.6e-22 77.5 0.1 1.0 1 0 0 1 1 1 1 LSM domain Frigida PF07899.11 ORX59037.1 - 0.11 11.8 0.0 0.12 11.6 0.0 1.0 1 0 0 1 1 1 0 Frigida-like protein CLPTM1 PF05602.12 ORX59038.1 - 5.5e-147 490.2 0.4 6.8e-147 489.9 0.4 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) 2TM PF13239.6 ORX59038.1 - 0.0025 18.1 3.1 0.013 15.8 3.1 2.2 1 0 0 1 1 1 1 2TM domain PQ-loop PF04193.14 ORX59038.1 - 0.021 14.6 0.1 0.062 13.1 0.1 1.8 1 0 0 1 1 1 0 PQ loop repeat Alpha_L_fucos PF01120.17 ORX59039.1 - 3.6e-82 276.6 2.5 5e-82 276.2 2.5 1.1 1 0 0 1 1 1 1 Alpha-L-fucosidase GHL6 PF14871.6 ORX59039.1 - 0.14 12.3 0.1 0.49 10.5 0.0 2.0 2 0 0 2 2 2 0 Hypothetical glycosyl hydrolase 6 SlyX PF04102.12 ORX59040.1 - 0.078 13.6 0.3 7.3 7.3 0.1 2.3 2 0 0 2 2 2 0 SlyX Pkinase PF00069.25 ORX59041.1 - 1.4e-65 221.3 0.0 1.7e-65 221.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59041.1 - 6.5e-33 114.1 0.0 8.7e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX59041.1 - 1.8e-05 24.2 0.0 4.1e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX59041.1 - 0.0011 18.0 0.0 0.0022 17.0 0.0 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX59041.1 - 0.0099 15.2 0.2 0.042 13.2 0.2 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX59041.1 - 0.04 12.7 0.0 0.074 11.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PBP1_TM PF14812.6 ORX59042.1 - 2 8.8 7.6 0.69 10.3 2.7 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AMP-binding PF00501.28 ORX59043.1 - 2.1e-88 296.8 0.2 2.5e-88 296.5 0.2 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX59043.1 - 0.037 15.0 0.1 0.095 13.7 0.1 1.7 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Pox_Ag35 PF03286.14 ORX59045.1 - 0.022 14.5 1.8 0.039 13.8 1.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 ORX59045.1 - 1 9.8 7.3 2.3 8.7 7.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2722 PF10846.8 ORX59045.1 - 1.9 7.4 7.4 0.043 12.8 0.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) NOA36 PF06524.12 ORX59045.1 - 4.1 6.6 7.1 5.7 6.2 7.1 1.2 1 0 0 1 1 1 0 NOA36 protein eIF_4EBP PF05456.11 ORX59372.1 - 1.1e-06 28.6 0.1 1.5e-06 28.1 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Zip PF02535.22 ORX59373.1 - 5.6e-51 173.7 20.4 1.1e-50 172.8 20.4 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter Pkinase PF00069.25 ORX59374.1 - 7.5e-28 97.6 0.0 9.6e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59374.1 - 5.9e-16 58.5 0.0 7.6e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX59374.1 - 1.1e-09 37.6 0.1 1.6e-09 37.1 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX59374.1 - 0.00033 20.6 0.0 0.018 14.9 0.0 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ORX59374.1 - 0.013 14.5 0.2 0.019 14.0 0.2 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 ORX59374.1 - 0.021 14.4 0.2 0.035 13.7 0.2 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Zn_clus PF00172.18 ORX59375.1 - 8.8e-10 38.5 9.4 8.8e-10 38.5 9.4 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TAL_FSA PF00923.19 ORX59376.1 - 4.3e-101 338.0 0.0 4.9e-101 337.9 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase 4HBT_3 PF13622.6 ORX59377.1 - 2.4e-61 208.1 0.2 2.9e-61 207.9 0.2 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 ORX59377.1 - 3.2e-35 120.9 0.0 1.5e-28 99.3 0.0 2.9 2 1 0 2 2 2 2 Acyl-CoA thioesterase Succ_CoA_lig PF13607.6 ORX59377.1 - 0.082 12.7 0.0 0.34 10.7 0.0 1.9 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain F-box PF00646.33 ORX59378.1 - 3.2e-08 33.2 0.5 7.4e-08 32.1 0.5 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX59378.1 - 1.4e-07 31.3 2.5 2.9e-07 30.3 2.5 1.5 1 0 0 1 1 1 1 F-box-like Histone PF00125.24 ORX59379.1 - 2.4e-07 31.1 0.0 2.8e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 HemX PF04375.14 ORX59379.1 - 0.014 14.7 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase AAA_lid_2 PF17863.1 ORX59379.1 - 0.041 13.7 0.0 0.068 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA lid domain CBFD_NFYB_HMF PF00808.23 ORX59379.1 - 0.047 14.0 0.0 0.092 13.0 0.0 1.7 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SUD-M PF11633.8 ORX59381.1 - 0.057 13.1 0.1 0.081 12.6 0.1 1.2 1 0 0 1 1 1 0 Single-stranded poly(A) binding domain SH3_9 PF14604.6 ORX59383.1 - 4.4e-39 132.1 7.6 3.3e-14 52.5 0.4 3.5 3 0 0 3 3 3 3 Variant SH3 domain SH3_1 PF00018.28 ORX59383.1 - 5.2e-39 131.6 5.2 1.1e-12 47.4 0.1 3.6 3 0 0 3 3 3 3 SH3 domain SHD1 PF03983.12 ORX59383.1 - 6.7e-32 109.1 0.0 1.3e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_2 PF07653.17 ORX59383.1 - 6.6e-23 80.2 0.0 1.3e-08 34.4 0.0 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_10 PF17902.1 ORX59383.1 - 3.2e-05 23.9 0.0 0.21 11.7 0.0 3.5 3 0 0 3 3 3 2 SH3 domain SH3_3 PF08239.11 ORX59383.1 - 0.022 15.0 0.9 1 9.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial SH3 domain PH_6 PF15406.6 ORX59383.1 - 0.21 11.9 0.0 0.21 11.9 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain SAM_4 PF18017.1 ORX59383.1 - 0.22 11.5 0.0 0.42 10.6 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF3419 PF11899.8 ORX59384.1 - 3.3e-147 490.7 0.7 4.5e-147 490.3 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) Methyltransf_25 PF13649.6 ORX59384.1 - 2.1e-08 34.7 0.0 1.2e-07 32.3 0.0 2.3 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX59384.1 - 9.7e-08 32.0 0.0 3e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX59384.1 - 1.1e-06 29.2 0.0 3.6e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX59384.1 - 2.7e-05 24.0 0.0 6.4e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX59384.1 - 3e-05 23.5 0.0 9e-05 21.9 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 ORX59384.1 - 7e-05 23.4 0.1 0.00046 20.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX59384.1 - 0.019 14.5 0.0 0.059 12.8 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase Homeodomain PF00046.29 ORX59385.1 - 2.3e-07 30.5 2.4 3.4e-07 30.0 2.4 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX59385.1 - 0.00019 21.3 0.5 0.00039 20.3 0.5 1.5 1 0 0 1 1 1 1 Homeobox KN domain Lipase_GDSL PF00657.22 ORX59386.1 - 1.8e-07 31.3 0.0 2.4e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 ORX59386.1 - 4.3e-06 27.2 0.0 6.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family TRAP_beta PF05753.14 ORX59386.1 - 0.018 14.5 0.1 0.032 13.6 0.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) MFS_1 PF07690.16 ORX59387.1 - 3.8e-35 121.5 35.0 7.9e-18 64.5 34.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX59387.1 - 0.12 11.2 23.7 0.036 12.9 6.1 3.3 2 1 1 3 3 3 0 Sugar (and other) transporter VHS PF00790.19 ORX59388.1 - 7.1e-33 113.4 0.0 3.6e-27 94.9 0.0 3.1 3 0 0 3 3 3 2 VHS domain Alpha_adaptinC2 PF02883.20 ORX59388.1 - 4.9e-20 71.9 0.4 1.3e-19 70.6 0.4 1.7 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 ORX59388.1 - 5.1e-17 61.9 3.8 5.3e-17 61.9 1.3 2.4 3 0 0 3 3 3 1 GAT domain GGA_N-GAT PF18308.1 ORX59388.1 - 8e-06 25.4 3.4 1.5e-05 24.5 0.0 2.7 2 1 0 2 2 2 1 GGA N-GAT domain DUF5321 PF17254.2 ORX59388.1 - 0.022 14.2 0.1 0.047 13.1 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5321) Takusan PF04822.13 ORX59388.1 - 0.052 13.4 0.4 0.16 11.8 0.3 1.9 1 1 0 1 1 1 0 Takusan ubiquitin PF00240.23 ORX59390.1 - 0.046 13.5 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family DUF2407_C PF13373.6 ORX59391.1 - 8.4e-28 97.3 11.4 1.1e-26 93.7 11.4 1.9 1 1 0 1 1 1 1 DUF2407 C-terminal domain EMC3_TMCO1 PF01956.16 ORX59391.1 - 0.0062 16.3 0.0 0.007 16.1 0.0 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like MtrB PF05440.12 ORX59391.1 - 0.11 13.0 0.6 14 6.1 0.0 2.2 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B Death PF00531.22 ORX59391.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 Death domain Ribosomal_S19 PF00203.21 ORX59392.1 - 7.3e-26 89.9 0.0 8.3e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Pro_isomerase PF00160.21 ORX59393.1 - 1e-48 165.6 0.1 1.1e-48 165.4 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ORX59394.1 - 4.7e-06 26.3 0.0 7.8e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 ORX59394.1 - 9.3e-05 23.2 0.0 0.00024 21.8 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 ORX59394.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Arrestin_C PF02752.22 ORX59395.1 - 0.038 14.4 0.1 0.2 12.1 0.1 2.1 2 1 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Aa_trans PF01490.18 ORX59396.1 - 2.8e-86 289.8 31.7 3.3e-86 289.6 31.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Methyltransf_5 PF01795.19 ORX59397.1 - 8.1e-80 268.6 0.0 1.4e-69 235.0 0.0 2.9 1 1 1 2 2 2 2 MraW methylase family FtsJ PF01728.19 ORX59397.1 - 0.0009 19.4 0.0 0.62 10.2 0.0 2.2 2 0 0 2 2 2 2 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 ORX59397.1 - 0.026 15.2 0.0 0.098 13.4 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain PSP1 PF04468.12 ORX59398.1 - 3.5e-33 113.7 1.8 4.4e-33 113.4 1.8 1.1 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Pkinase PF00069.25 ORX59400.1 - 8.9e-74 248.2 0.0 1.1e-73 247.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59400.1 - 2.5e-30 105.6 0.0 6.8e-22 78.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX59400.1 - 1.5e-08 34.3 0.3 0.015 14.7 0.0 3.2 2 1 1 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 ORX59400.1 - 0.00067 18.5 0.0 0.001 17.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX59400.1 - 0.013 15.5 0.0 1.2 9.0 0.1 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX59400.1 - 0.042 13.2 0.0 0.071 12.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX59400.1 - 0.17 10.8 0.3 0.51 9.2 0.0 1.8 3 0 0 3 3 3 0 Haspin like kinase domain ATP-synt_ab PF00006.25 ORX59401.1 - 1e-71 241.0 0.0 1.5e-71 240.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ORX59401.1 - 1.3e-46 158.0 0.0 2.3e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ORX59401.1 - 3.3e-20 72.4 1.1 8.5e-20 71.1 1.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 ORX59401.1 - 0.02 15.1 0.2 0.059 13.5 0.2 1.9 1 1 0 1 1 1 0 HAS barrel domain PX PF00787.24 ORX59402.1 - 2e-20 72.9 1.2 2e-20 72.9 1.2 2.6 3 0 0 3 3 3 1 PX domain DUF5572 PF17733.1 ORX59402.1 - 1.4 8.8 4.0 3.2 7.6 4.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5572) PCNA_N PF00705.18 ORX59403.1 - 2.3e-54 182.5 5.2 4.5e-54 181.5 2.5 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ORX59403.1 - 6.3e-48 162.2 0.0 1e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 ORX59403.1 - 4.5e-08 32.9 0.0 5.7e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 ORX59403.1 - 0.00034 19.8 0.1 0.0056 15.8 0.1 2.1 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 ORX59403.1 - 0.00047 19.4 0.0 0.012 14.7 0.0 2.1 2 0 0 2 2 2 1 Hus1-like protein Fcf1 PF04900.12 ORX59404.1 - 3.6e-26 91.5 0.3 6.3e-26 90.7 0.3 1.4 1 0 0 1 1 1 1 Fcf1 SWI2_SNF2 PF18766.1 ORX59404.1 - 0.024 14.3 0.5 0.07 12.8 0.4 1.8 1 1 1 2 2 2 0 SWI2/SNF2 ATPase Ribosomal_S9 PF00380.19 ORX59405.1 - 5.2e-46 156.1 0.2 8.4e-46 155.4 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Sel1 PF08238.12 ORX59406.1 - 9.7e-23 80.1 16.8 2.3e-07 31.2 2.0 6.9 7 0 0 7 7 7 4 Sel1 repeat MPP6 PF10175.9 ORX59406.1 - 0.072 13.6 1.3 0.23 12.0 1.3 1.8 1 0 0 1 1 1 0 M-phase phosphoprotein 6 DNA_pol_phi PF04931.13 ORX59406.1 - 0.52 8.4 6.6 0.87 7.6 6.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 ORX59406.1 - 0.58 9.4 5.8 1.1 8.5 5.8 1.4 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 ORX59406.1 - 0.68 9.6 3.3 2.4 7.8 3.3 1.9 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 ORX59406.1 - 0.84 9.6 5.6 0.3 11.1 2.0 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal NOA36 PF06524.12 ORX59406.1 - 3.6 6.8 9.8 7.8 5.7 9.8 1.5 1 0 0 1 1 1 0 NOA36 protein SURF6 PF04935.12 ORX59407.1 - 8.2e-33 113.9 49.6 8.2e-33 113.9 49.6 2.2 2 0 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 ORX59407.1 - 1.6e-17 63.9 0.8 1.6e-17 63.9 0.8 5.9 4 1 0 4 4 4 1 60S ribosome biogenesis protein Rrp14 DUF1168 PF06658.12 ORX59408.1 - 5e-38 130.0 11.9 5e-38 130.0 11.9 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1168) Peptidase_S49_N PF08496.10 ORX59408.1 - 4.8 7.2 14.9 0.88 9.6 11.0 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DIL PF01843.19 ORX59409.1 - 6.9e-27 93.8 5.1 6.9e-27 93.8 5.1 2.4 2 0 0 2 2 2 1 DIL domain Ank_2 PF12796.7 ORX59409.1 - 1.1e-14 54.7 0.0 3e-14 53.4 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX59409.1 - 1.3e-10 41.6 0.0 1.1e-05 25.8 0.0 2.8 1 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX59409.1 - 2.1e-10 40.5 0.1 0.00053 20.3 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX59409.1 - 5.7e-10 39.3 0.0 4.9e-06 26.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX59409.1 - 1.5e-05 25.0 0.0 0.24 12.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat FYVE PF01363.21 ORX59410.1 - 3.7e-19 68.6 7.7 7.1e-19 67.7 7.7 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ORX59410.1 - 0.066 13.4 10.1 0.035 14.3 7.8 1.8 2 1 0 2 2 2 0 FYVE-type zinc finger C1_1 PF00130.22 ORX59410.1 - 3.9 7.5 9.9 0.2 11.6 4.3 1.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2039 PF10217.9 ORX59410.1 - 9.6 6.6 10.7 15 6.0 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2039) TFIID_20kDa PF03847.13 ORX59411.1 - 8e-34 116.0 0.3 1.3e-33 115.3 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A Histone PF00125.24 ORX59411.1 - 1.7e-05 25.2 0.8 4.9e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX59411.1 - 5.3e-05 23.4 0.1 0.00012 22.2 0.1 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ORX59411.1 - 0.0028 17.7 0.1 0.011 15.8 0.0 2.1 2 0 0 2 2 2 1 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 ORX59411.1 - 0.0085 16.2 0.1 0.21 11.7 0.0 2.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CCDC-167 PF15188.6 ORX59411.1 - 0.23 11.8 2.8 0.56 10.6 2.8 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 ADH_N PF08240.12 ORX59413.1 - 2.9e-30 104.4 4.7 2.9e-30 104.4 4.7 2.0 3 0 0 3 3 3 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX59413.1 - 6.7e-18 64.9 0.5 1e-16 61.1 0.1 2.5 2 1 1 3 3 3 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ORX59413.1 - 2.1e-11 43.7 0.0 3.6e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ORX59413.1 - 1.2e-05 26.3 0.0 2.6e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase HI0933_like PF03486.14 ORX59413.1 - 0.00063 18.6 0.0 0.00089 18.1 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.6 ORX59413.1 - 0.0016 18.8 0.0 0.0036 17.7 0.0 1.6 1 1 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ORX59413.1 - 0.0017 17.7 0.1 0.0027 17.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ORX59413.1 - 0.0023 18.5 0.0 0.0055 17.2 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX59413.1 - 0.007 16.6 0.0 0.019 15.2 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 ORX59413.1 - 0.0091 15.9 0.0 0.019 14.9 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ORX59413.1 - 0.0098 15.2 0.3 0.0098 15.2 0.3 2.0 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_2 PF07992.14 ORX59413.1 - 0.0099 15.1 0.0 0.019 14.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_N PF03721.14 ORX59413.1 - 0.028 14.0 0.0 0.054 13.1 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 ORX59413.1 - 0.033 13.8 0.3 0.047 13.3 0.3 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase 2-Hacid_dh_C PF02826.19 ORX59413.1 - 0.12 11.8 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 ORX59413.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF485 PF04341.12 ORX59414.1 - 0.05 13.6 0.5 0.05 13.6 0.5 3.5 2 1 1 3 3 3 0 Protein of unknown function, DUF485 DUF4131 PF13567.6 ORX59414.1 - 1 9.0 4.6 3.6 7.2 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) UPF0220 PF05255.11 ORX59414.1 - 1.4 8.5 8.9 0.19 11.3 1.7 2.6 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0220) YtpI PF14007.6 ORX59414.1 - 6.8 6.9 10.6 0.068 13.3 1.1 2.5 3 0 0 3 3 3 0 YtpI-like protein LMWPc PF01451.21 ORX59415.1 - 1.1e-46 158.8 0.0 1.2e-46 158.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase MMR_HSR1_Xtn PF16897.5 ORX59416.1 - 2.6e-41 139.9 3.0 4.7e-41 139.1 3.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ORX59416.1 - 3.5e-22 78.2 0.1 5.9e-22 77.5 0.1 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ORX59416.1 - 2.3e-20 72.8 0.0 4.9e-20 71.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX59416.1 - 1.8e-10 40.6 0.0 2.9e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX59416.1 - 0.0024 17.8 0.7 0.02 14.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ORX59416.1 - 0.0061 16.6 1.8 0.3 11.1 0.0 2.5 2 1 0 3 3 3 1 Dynamin family Arf PF00025.21 ORX59416.1 - 0.0084 15.6 0.0 0.027 13.9 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX59416.1 - 0.017 14.5 0.0 0.035 13.5 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_28 PF13521.6 ORX59416.1 - 0.042 14.1 0.1 0.087 13.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ORX59416.1 - 0.048 13.9 0.6 0.69 10.2 0.0 2.5 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 ORX59416.1 - 0.048 12.6 0.0 0.093 11.7 0.0 1.6 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AIG1 PF04548.16 ORX59416.1 - 0.05 12.9 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 AIG1 family F-box-like PF12937.7 ORX59417.1 - 2e-10 40.4 3.8 4.4e-10 39.3 2.6 2.2 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ORX59417.1 - 1e-08 35.3 6.1 0.017 15.5 0.1 6.0 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX59417.1 - 7.8e-06 25.6 0.3 7.3e-05 22.5 0.5 2.6 2 0 0 2 2 2 1 F-box domain TPR_2 PF07719.17 ORX59417.1 - 1.7e-05 24.6 0.0 0.024 14.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX59417.1 - 0.0021 18.8 0.6 0.21 12.5 0.0 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX59417.1 - 0.015 15.5 1.3 0.047 13.8 0.4 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX59417.1 - 0.044 14.3 0.4 1.8 9.1 0.1 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX59417.1 - 0.1 13.3 1.4 2.6 8.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_8 PF13855.6 ORX59417.1 - 0.34 10.7 7.4 0.41 10.4 0.3 3.9 3 1 0 3 3 3 0 Leucine rich repeat LRR_6 PF13516.6 ORX59417.1 - 0.46 10.7 6.7 4.4 7.6 0.1 5.1 5 0 0 5 5 5 0 Leucine Rich repeat Glyco_hydro_15 PF00723.21 ORX59418.1 - 1.1e-73 248.6 0.3 1.2e-73 248.4 0.3 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Pkinase PF00069.25 ORX59419.1 - 2.2e-76 256.7 0.0 3.5e-76 256.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59419.1 - 9.1e-35 120.2 0.0 1.9e-34 119.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX59419.1 - 0.00013 20.9 2.3 0.0016 17.3 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX59419.1 - 0.00048 19.5 0.2 0.77 9.0 0.1 3.2 3 0 0 3 3 3 2 Kinase-like RIO1 PF01163.22 ORX59419.1 - 0.011 15.4 0.4 0.07 12.7 0.4 2.0 1 1 0 1 1 1 0 RIO1 family APH PF01636.23 ORX59419.1 - 0.021 14.8 0.0 0.17 11.8 0.0 2.2 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1168 PF06658.12 ORX59419.1 - 1.1 9.1 6.3 0.21 11.4 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Lectin_N PF03954.14 ORX59420.1 - 0.27 11.0 0.9 0.47 10.2 0.9 1.4 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Baculo_11_kDa PF06143.11 ORX59420.1 - 1.3 8.6 4.8 0.19 11.3 0.3 1.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family Rhodanese_C PF12368.8 ORX59422.1 - 7.7e-14 51.8 12.4 1.7e-13 50.7 12.4 1.6 1 0 0 1 1 1 1 Rhodanase C-terminal UPF0176_N PF17773.1 ORX59422.1 - 1.3e-11 44.6 0.0 5.1e-11 42.8 0.0 2.1 1 0 0 1 1 1 1 UPF0176 acylphosphatase like domain Rhodanese PF00581.20 ORX59422.1 - 1.3e-08 35.3 0.1 2.7e-08 34.3 0.1 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Ta0938 PF11494.8 ORX59422.1 - 1.4 9.2 5.2 2.9 8.2 5.2 1.5 1 0 0 1 1 1 0 Ta0938 PP2C PF00481.21 ORX59423.1 - 9.2e-81 271.3 0.0 1.1e-80 271.0 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ORX59423.1 - 0.00021 21.3 0.1 0.045 13.7 0.1 2.3 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Caleosin PF05042.13 ORX59424.1 - 1.8e-43 148.4 0.6 2.7e-43 147.9 0.6 1.2 1 0 0 1 1 1 1 Caleosin related protein Ras PF00071.22 ORX59425.1 - 3.3e-55 186.1 0.0 3.8e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX59425.1 - 6.3e-21 74.8 0.0 9.8e-21 74.2 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX59425.1 - 1.3e-07 31.3 0.0 2.1e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX59425.1 - 0.003 17.0 0.0 0.0049 16.3 0.0 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit DNA_methylase PF00145.17 ORX59426.1 - 3.1e-30 105.7 0.0 4.5e-29 101.9 0.0 2.5 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase zf-RING_2 PF13639.6 ORX59427.1 - 6e-12 45.7 10.4 1.1e-11 44.8 10.4 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX59427.1 - 1.5e-09 37.5 10.3 2.9e-09 36.6 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX59427.1 - 3.8e-09 36.3 10.2 7e-09 35.4 10.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX59427.1 - 2.1e-07 30.5 3.4 2.1e-07 30.5 3.4 1.9 2 0 0 2 2 1 1 RING-like zinc finger zf-RING_5 PF14634.6 ORX59427.1 - 2.8e-06 27.2 9.0 5.2e-06 26.3 9.0 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX59427.1 - 6.4e-06 25.9 12.2 1.1e-05 25.1 12.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX59427.1 - 8.9e-06 25.6 2.0 8.9e-06 25.6 2.0 2.5 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 ORX59427.1 - 0.00052 20.2 11.7 0.0028 17.9 11.7 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ORX59427.1 - 0.0012 18.7 11.4 0.0029 17.4 11.5 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 CopD PF05425.13 ORX59427.1 - 0.013 15.8 0.3 0.027 14.8 0.3 1.4 1 0 0 1 1 1 0 Copper resistance protein D Ni_hydr_CYTB PF01292.20 ORX59427.1 - 0.014 15.0 0.6 0.023 14.3 0.6 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 zf-C3HC4_4 PF15227.6 ORX59427.1 - 0.02 15.0 9.7 0.055 13.6 9.7 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ORX59427.1 - 0.067 13.0 10.1 0.12 12.2 10.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF2370 PF10176.9 ORX59427.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Leader_Trp PF08255.11 ORX59427.1 - 0.13 12.3 1.9 0.54 10.3 1.9 2.0 1 0 0 1 1 1 0 Trp-operon Leader Peptide zf-RING_6 PF14835.6 ORX59427.1 - 0.24 11.3 4.7 0.49 10.3 4.7 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 ORX59427.1 - 0.27 11.3 7.0 0.75 9.9 7.0 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger 7TM_GPCR_Srz PF10325.9 ORX59427.1 - 1.7 7.9 4.3 2.9 7.2 3.1 1.9 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srz Transport_MerF PF11431.8 ORX59427.1 - 3.2 7.7 6.7 0.53 10.2 2.7 1.8 2 0 0 2 2 2 0 Membrane transport protein MerF DUF1729 PF08354.10 ORX59428.1 - 1.7e-156 520.5 0.0 5.8e-156 518.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 ORX59428.1 - 5.2e-72 243.0 0.0 1.9e-71 241.2 0.0 1.9 2 0 0 2 2 2 1 Acyl transferase domain FAS_I_H PF18314.1 ORX59428.1 - 2.5e-69 233.0 0.0 4.9e-69 232.0 0.0 1.5 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 ORX59428.1 - 8.5e-68 227.8 2.6 1.1e-67 227.4 0.0 2.6 3 0 0 3 3 3 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_meander PF17951.1 ORX59428.1 - 2.2e-46 157.3 0.0 5.6e-46 156.0 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 ORX59428.1 - 2.1e-32 112.8 0.0 4.3e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 ORX59428.1 - 3.9e-31 107.2 0.2 1.3e-30 105.5 0.2 1.9 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 ORX59428.1 - 1.4e-26 93.0 0.6 3.2e-26 91.8 0.6 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta ketoacyl-synt PF00109.26 ORX59428.1 - 2e-22 80.0 2.8 1.9e-21 76.8 0.0 3.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain MaoC_dehydrat_N PF13452.6 ORX59428.1 - 2.1e-19 69.9 0.0 6e-19 68.5 0.0 1.8 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase ACPS PF01648.20 ORX59428.1 - 2e-15 56.9 0.0 5.1e-15 55.6 0.0 1.8 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 ORX59428.1 - 1.8e-09 37.6 2.1 2.3e-09 37.3 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 ORX59428.1 - 0.0045 16.9 0.0 0.014 15.3 0.0 1.8 1 0 0 1 1 1 1 KR domain Thiolase_N PF00108.23 ORX59428.1 - 0.0051 16.2 0.2 0.015 14.6 0.2 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain IF-2B PF01008.17 ORX59429.1 - 0.1 11.8 0.4 0.26 10.4 0.1 1.7 2 0 0 2 2 2 0 Initiation factor 2 subunit family WD40 PF00400.32 ORX59430.1 - 7.9e-36 121.5 24.4 1.7e-07 31.8 0.5 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ORX59430.1 - 1.1e-12 47.4 8.5 0.00057 18.7 0.7 5.1 2 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ORX59430.1 - 2.5e-06 27.7 0.3 0.11 12.8 0.0 5.0 3 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX59430.1 - 2.3e-05 23.9 0.0 0.046 13.1 0.0 3.2 3 1 0 3 3 3 2 WD40-like domain PALB2_WD40 PF16756.5 ORX59430.1 - 0.0063 15.5 1.7 5.1 5.9 0.1 3.7 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 ORX59430.1 - 0.11 11.4 1.2 9.2 5.1 0.2 3.4 2 2 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Spc24 PF08286.11 ORX59430.1 - 0.12 12.6 2.2 0.31 11.3 2.2 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 YabA PF06156.13 ORX59430.1 - 0.48 11.1 1.8 1.1 9.9 1.8 1.5 1 0 0 1 1 1 0 Initiation control protein YabA Septin PF00735.18 ORX59432.1 - 2.9e-114 381.1 0.3 3.7e-114 380.8 0.3 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX59432.1 - 1.8e-08 34.5 0.1 5e-08 33.0 0.1 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX59432.1 - 2.4e-08 34.0 0.1 2.1e-06 27.7 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX59432.1 - 5.4e-06 26.1 0.0 0.00094 18.8 0.0 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ORX59432.1 - 7.7e-06 26.4 0.4 0.00063 20.2 0.4 2.3 1 1 0 1 1 1 1 AAA ATPase domain AIG1 PF04548.16 ORX59432.1 - 4.5e-05 22.9 0.0 8.3e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ORX59432.1 - 0.00017 21.7 0.8 0.47 10.5 0.3 2.6 1 1 1 2 2 2 2 Dynamin family ABC_tran PF00005.27 ORX59432.1 - 0.0017 18.9 0.4 0.0029 18.1 0.4 1.6 1 1 0 1 1 1 1 ABC transporter FtsK_SpoIIIE PF01580.18 ORX59432.1 - 0.002 17.6 0.0 0.0036 16.7 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_22 PF13401.6 ORX59432.1 - 0.0032 17.7 0.1 0.01 16.1 0.1 1.9 1 1 1 2 2 2 1 AAA domain AAA_14 PF13173.6 ORX59432.1 - 0.0037 17.3 0.1 0.015 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX59432.1 - 0.0064 16.0 0.1 0.08 12.5 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region Gtr1_RagA PF04670.12 ORX59432.1 - 0.0083 15.5 0.1 0.3 10.4 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ORX59432.1 - 0.011 14.9 0.9 0.21 10.7 0.2 2.1 1 1 1 2 2 2 0 G-protein alpha subunit Ras PF00071.22 ORX59432.1 - 0.011 15.3 0.1 0.049 13.2 0.0 2.0 2 0 0 2 2 2 0 Ras family Roc PF08477.13 ORX59432.1 - 0.012 15.9 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ORX59432.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 ORX59432.1 - 0.026 13.7 0.1 0.056 12.6 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain IIGP PF05049.13 ORX59432.1 - 0.037 13.1 0.1 0.083 11.9 0.1 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_33 PF13671.6 ORX59432.1 - 0.042 14.0 0.5 0.18 12.0 0.5 2.3 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX59432.1 - 0.065 13.5 0.7 0.9 9.8 0.6 2.5 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 ORX59432.1 - 0.074 12.2 0.0 0.14 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 ORX59432.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ORX59432.1 - 0.12 12.0 0.0 0.37 10.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATP_bind_3 PF01171.20 ORX59432.1 - 0.21 11.3 1.6 2.1 8.1 0.9 2.5 2 1 0 2 2 2 0 PP-loop family RabGAP-TBC PF00566.18 ORX59433.1 - 9.7e-47 159.4 3.6 1.4e-46 158.8 3.6 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PTEN_C2 PF10409.9 ORX59434.1 - 5.9e-14 52.0 0.0 1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Y_phosphatase3 PF13350.6 ORX59434.1 - 3.5e-07 30.4 0.0 5e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX59434.1 - 8.9e-07 28.7 0.0 1.2e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ORX59434.1 - 0.00041 20.2 0.1 0.0015 18.3 0.0 1.7 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ORX59434.1 - 0.0032 17.6 0.0 0.0044 17.1 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate CDKN3 PF05706.12 ORX59434.1 - 0.0063 16.2 0.0 0.0089 15.7 0.0 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ORX59434.1 - 0.037 13.6 0.0 0.066 12.8 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family NmrA PF05368.13 ORX59435.1 - 4.1e-42 144.3 0.9 5.4e-42 143.9 0.9 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 ORX59435.1 - 4.3e-23 82.2 0.2 5.6e-23 81.8 0.2 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX59435.1 - 1.1e-05 25.0 0.1 9.9e-05 21.9 0.1 2.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ORX59435.1 - 0.019 14.0 0.5 0.039 13.0 0.5 1.4 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Mur_ligase PF01225.25 ORX59435.1 - 0.18 12.1 1.0 7.8 6.9 0.1 2.8 3 1 0 3 3 3 0 Mur ligase family, catalytic domain Pkr1 PF08636.10 ORX59436.1 - 1.3e-23 82.9 1.4 1.5e-23 82.7 1.4 1.0 1 0 0 1 1 1 1 ER protein Pkr1 zf-H2C2_2 PF13465.6 ORX59437.1 - 3.8e-15 55.5 20.2 9e-08 32.2 0.9 3.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 ORX59437.1 - 2.4e-11 43.4 25.1 7.5e-05 23.0 1.4 3.3 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX59437.1 - 6.8e-09 35.8 23.8 0.0047 17.7 1.5 3.1 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX59437.1 - 9.1e-06 25.8 4.8 0.016 15.5 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 ORX59437.1 - 3.4e-05 24.1 10.3 0.0024 18.1 3.9 2.0 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2HC_2 PF13913.6 ORX59437.1 - 0.0053 16.6 0.5 0.0053 16.6 0.5 2.9 3 1 0 3 3 3 1 zinc-finger of a C2HC-type zf-met PF12874.7 ORX59437.1 - 0.0063 16.9 12.5 0.22 12.0 0.3 3.9 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX59437.1 - 0.016 14.9 1.2 0.016 14.9 1.2 3.3 3 1 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ORX59437.1 - 0.46 10.5 13.6 0.5 10.4 0.8 3.0 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ORX59437.1 - 0.57 10.5 6.6 3.1 8.2 1.9 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DLIC PF05783.11 ORX59438.1 - 2.4e-68 231.1 15.1 1.3e-49 169.4 0.4 5.0 2 1 1 3 3 3 3 Dynein light intermediate chain (DLIC) AAA_29 PF13555.6 ORX59438.1 - 0.0031 17.2 0.2 0.0075 16.0 0.2 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX59438.1 - 0.035 14.5 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 ORX59438.1 - 0.066 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Roc PF08477.13 ORX59438.1 - 0.068 13.4 0.0 0.67 10.2 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ORX59438.1 - 0.073 13.6 0.0 0.15 12.5 0.0 1.5 1 0 0 1 1 1 0 ABC transporter G-alpha PF00503.20 ORX59438.1 - 0.093 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 G-protein alpha subunit MMR_HSR1 PF01926.23 ORX59438.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase LETM1 PF07766.13 ORX59440.1 - 1e-107 359.5 2.1 1e-107 359.5 2.1 2.9 2 1 1 3 3 3 1 LETM1-like protein SAP PF02037.27 ORX59440.1 - 0.0026 17.4 0.1 0.026 14.3 0.0 2.7 3 0 0 3 3 3 1 SAP domain Allexi_40kDa PF05549.11 ORX59440.1 - 1.4 8.3 15.0 0.02 14.4 5.3 2.4 1 1 0 2 2 2 0 Allexivirus 40kDa protein DnaJ_C PF01556.18 ORX59442.1 - 4.5e-37 127.4 0.0 5.9e-37 127.0 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX59442.1 - 3.4e-26 91.2 3.6 7.5e-26 90.0 3.6 1.6 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ORX59442.1 - 1.9e-09 37.7 17.1 4.2e-09 36.7 17.1 1.6 1 0 0 1 1 1 1 DnaJ central domain ING PF12998.7 ORX59443.1 - 2.9e-17 63.1 1.2 4.5e-17 62.5 1.2 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX59443.1 - 2.7e-06 27.1 9.0 5e-06 26.3 9.0 1.4 1 0 0 1 1 1 1 PHD-finger BRE1 PF08647.11 ORX59443.1 - 0.014 15.4 2.3 2.4 8.3 0.2 2.3 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase zf-HC5HC2H PF13771.6 ORX59443.1 - 0.027 14.7 2.8 0.055 13.7 2.8 1.5 1 0 0 1 1 1 0 PHD-like zinc-binding domain MFS_1 PF07690.16 ORX59444.1 - 8.8e-44 149.9 34.0 8.8e-44 149.9 34.0 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX59444.1 - 3e-10 39.6 9.4 3e-10 39.6 9.4 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_2 PF13347.6 ORX59444.1 - 2.6e-05 23.0 10.7 2.6e-05 23.0 10.7 3.1 2 1 1 3 3 3 2 MFS/sugar transport protein SieB PF14163.6 ORX59444.1 - 0.11 12.0 0.2 3.3 7.2 0.0 2.8 3 0 0 3 3 3 0 Super-infection exclusion protein B OATP PF03137.20 ORX59444.1 - 3.5 5.8 16.5 0.083 11.2 4.2 3.0 1 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family DUF2721 PF11026.8 ORX59444.1 - 7 6.6 10.7 10 6.0 0.0 4.2 3 1 2 5 5 5 0 Protein of unknown function (DUF2721) RGS PF00615.19 ORX59445.1 - 0.00013 22.3 0.0 0.00023 21.4 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain PDEase_I PF00233.19 ORX59446.1 - 1.3e-67 228.1 0.0 1.6e-67 227.7 0.0 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ORX59446.1 - 0.0019 18.4 0.1 0.0043 17.3 0.1 1.6 1 0 0 1 1 1 1 HD domain Arf PF00025.21 ORX59447.1 - 1.6e-63 213.3 0.0 1.8e-63 213.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX59447.1 - 9.5e-10 38.2 0.0 1.3e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ORX59447.1 - 6.9e-09 35.3 0.0 2.8e-05 23.4 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ORX59447.1 - 5e-07 30.0 0.0 1.3e-06 28.6 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX59447.1 - 2.6e-06 27.5 0.0 3.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ORX59447.1 - 1.2e-05 24.9 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ORX59447.1 - 6.9e-05 22.3 0.0 7.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ORX59447.1 - 0.048 13.4 0.0 0.12 12.2 0.0 1.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 ORX59447.1 - 0.052 13.1 0.0 2.1 7.9 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sod_Fe_C PF02777.18 ORX59448.1 - 1.3e-38 131.2 0.2 3.3e-38 130.0 0.2 1.7 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ORX59448.1 - 2e-33 114.7 3.8 2.6e-33 114.3 2.9 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain APS_kinase PF01583.20 ORX59449.1 - 2.1e-72 242.2 0.0 2.6e-72 241.9 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 ORX59449.1 - 5e-08 33.2 0.0 8.4e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 ORX59449.1 - 0.001 18.6 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 ORX59449.1 - 0.0016 19.0 0.0 0.0021 18.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ORX59449.1 - 0.0075 16.0 0.1 0.012 15.3 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX59449.1 - 0.047 14.1 0.1 0.055 13.8 0.1 1.3 1 1 0 1 1 1 0 AAA ATPase domain DUF463 PF04317.12 ORX59449.1 - 0.12 11.3 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 YcjX-like family, DUF463 ABC_tran PF00005.27 ORX59449.1 - 0.15 12.6 0.0 0.17 12.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter DOT1 PF08123.13 ORX59450.1 - 5.4e-72 241.6 0.2 7.7e-72 241.1 0.2 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 ORX59450.1 - 0.00015 22.4 0.1 0.00046 20.8 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX59450.1 - 0.00043 20.1 0.0 0.00092 19.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX59450.1 - 0.004 16.5 1.4 1 8.6 0.3 2.4 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 ORX59450.1 - 0.0068 17.0 0.1 0.035 14.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 ORX59450.1 - 0.046 13.5 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RGS PF00615.19 ORX59450.1 - 0.098 12.9 0.3 0.47 10.7 0.2 2.1 1 1 1 2 2 2 0 Regulator of G protein signaling domain Blo-t-5 PF11642.8 ORX59450.1 - 0.11 12.4 0.4 1.8 8.6 0.0 2.6 3 0 0 3 3 3 0 Mite allergen Blo t 5 Endonuclease_5 PF04493.14 ORX59451.1 - 1.7e-65 220.4 0.0 1.9e-65 220.2 0.0 1.0 1 0 0 1 1 1 1 Endonuclease V Glyco_tranf_2_3 PF13641.6 ORX59452.1 - 1.5e-16 61.0 0.3 8.7e-14 52.0 0.1 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 ORX59452.1 - 8.4e-07 28.0 5.4 8.4e-07 28.0 5.4 3.3 3 1 0 3 3 3 1 Chitin synthase Glyco_transf_21 PF13506.6 ORX59452.1 - 1.2e-06 28.2 0.1 3e-06 26.8 0.1 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 ORX59452.1 - 2.7e-05 24.1 0.0 0.01 15.6 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 ORX59452.1 - 0.00014 21.9 21.0 0.00014 21.9 21.0 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 CoA_binding PF02629.19 ORX59453.1 - 6.7e-31 106.8 1.0 6.7e-31 106.8 1.0 2.2 3 0 0 3 3 3 1 CoA binding domain Ligase_CoA PF00549.19 ORX59453.1 - 7.1e-25 87.6 0.4 1.4e-24 86.7 0.4 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 ORX59453.1 - 2.6e-07 30.5 0.0 4.5e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain Glyco_trans_1_4 PF13692.6 ORX59453.1 - 0.0006 20.2 0.2 0.25 11.8 0.1 2.2 2 0 0 2 2 2 2 Glycosyl transferases group 1 SelP_N PF04592.14 ORX59454.1 - 0.025 14.0 15.1 0.042 13.3 15.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Chorion_2 PF03964.15 ORX59454.1 - 4.7 8.1 9.1 13 6.7 9.1 1.8 1 1 0 1 1 1 0 Chorion family 2 NicO PF03824.16 ORX59454.1 - 9.5 5.5 6.8 16 4.7 6.8 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein Cupin_8 PF13621.6 ORX59455.1 - 8.5e-22 78.1 3.6 1.2e-21 77.5 3.6 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ORX59455.1 - 1.5e-16 60.8 0.9 4.5e-16 59.3 0.7 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase GPI PF06560.11 ORX59455.1 - 0.069 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Patched PF02460.18 ORX59455.1 - 0.88 7.6 2.8 0.32 9.0 0.1 1.5 2 0 0 2 2 2 0 Patched family OEP PF02321.18 ORX59456.1 - 0.021 14.6 4.3 0.021 14.6 4.3 1.6 2 0 0 2 2 2 0 Outer membrane efflux protein APG6_N PF17675.1 ORX59456.1 - 0.041 14.4 9.0 0.048 14.2 8.0 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Prominin PF05478.11 ORX59456.1 - 0.09 10.7 1.3 0.11 10.5 1.3 1.1 1 0 0 1 1 1 0 Prominin FUSC PF04632.12 ORX59456.1 - 0.45 9.0 8.8 0.73 8.3 8.7 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family DUF4407 PF14362.6 ORX59456.1 - 0.99 8.7 4.8 1.3 8.3 4.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med9 PF07544.13 ORX59456.1 - 1.7 8.8 6.8 8.4 6.6 1.4 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Retrotrans_gag PF03732.17 ORX59456.1 - 1.9 8.8 5.1 0.26 11.6 0.5 1.9 2 0 0 2 2 2 0 Retrotransposon gag protein OmpH PF03938.14 ORX59456.1 - 3.2 8.1 11.2 0.87 9.9 4.5 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) NIF PF03031.18 ORX59458.1 - 1.7e-47 161.1 0.6 2e-47 160.8 0.6 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Ubiq_cyt_C_chap PF03981.12 ORX59459.1 - 9.2e-33 113.3 0.1 1.3e-32 112.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone PSP1 PF04468.12 ORX59460.1 - 1.4e-33 115.0 4.3 3.7e-33 113.7 2.3 2.1 2 0 0 2 2 2 1 PSP1 C-terminal conserved region DnaG_DnaB_bind PF08278.11 ORX59460.1 - 0.034 14.7 0.1 0.056 14.0 0.1 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding GMP_PDE_delta PF05351.11 ORX59460.1 - 0.094 12.8 0.9 0.2 11.7 0.7 1.6 2 0 0 2 2 2 0 GMP-PDE, delta subunit Ribosomal_L3 PF00297.22 ORX59461.1 - 5.9e-183 607.9 9.3 6.7e-183 607.8 9.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Pkinase PF00069.25 ORX59462.1 - 2e-22 79.8 0.0 9e-22 77.7 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59462.1 - 1.1e-08 34.8 0.0 3.6e-08 33.0 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX59462.1 - 0.001 18.5 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PNP_phzG_C PF10590.9 ORX59462.1 - 0.074 13.1 0.1 0.23 11.6 0.1 1.9 1 0 0 1 1 1 0 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Kinase-like PF14531.6 ORX59462.1 - 0.11 11.8 0.1 4.5 6.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Myb_DNA-binding PF00249.31 ORX59463.1 - 1.1e-08 35.1 0.0 2.4e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ORX59463.1 - 2e-07 30.7 3.6 3.2e-07 30.1 3.6 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-bind_6 PF13921.6 ORX59463.1 - 0.00073 19.7 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain C1_2 PF03107.16 ORX59463.1 - 0.00098 19.4 3.3 0.0021 18.4 3.3 1.5 1 0 0 1 1 1 1 C1 domain Zn_ribbon_2 PF12674.7 ORX59463.1 - 0.0068 17.0 4.3 0.0068 17.0 4.3 2.5 3 0 0 3 3 3 1 Putative zinc ribbon domain DUF848 PF05852.11 ORX59463.1 - 0.063 13.4 0.5 11 6.1 1.0 2.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) zf-UBR PF02207.20 ORX59463.1 - 0.14 12.3 7.4 0.43 10.8 7.4 1.7 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) CTNNBL PF08216.11 ORX59463.1 - 0.54 10.5 3.3 1 9.5 1.1 2.3 1 1 1 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Adap_comp_sub PF00928.21 ORX59464.1 - 2.8e-66 223.6 0.0 3.5e-66 223.3 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX59464.1 - 4.2e-07 30.0 0.1 5.1e-06 26.5 0.1 2.1 2 0 0 2 2 2 1 Clathrin adaptor complex small chain Pkinase PF00069.25 ORX59465.1 - 1.3e-14 54.2 0.0 2.6e-14 53.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Mad3_BUB1_I PF08311.12 ORX59465.1 - 3.7e-10 39.8 0.1 9e-10 38.6 0.1 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Pkinase_Tyr PF07714.17 ORX59465.1 - 2.5e-05 23.7 0.0 3.9e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ORX59465.1 - 0.0004 20.1 0.2 0.0063 16.2 0.0 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX59465.1 - 0.46 10.4 4.8 0.45 10.4 0.4 2.6 2 1 1 3 3 3 0 Phosphotransferase enzyme family SH3_1 PF00018.28 ORX59466.1 - 1.1e-09 37.7 0.0 2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX59466.1 - 8.2e-08 32.0 0.0 1.6e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FCH PF00611.23 ORX59466.1 - 3.1e-07 30.6 2.5 3.8e-07 30.3 0.2 2.4 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 ORX59466.1 - 1.3e-06 28.0 0.0 2.4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 ORX59466.1 - 6.9e-05 22.7 9.2 0.00016 21.5 6.5 2.8 2 1 0 2 2 2 1 BAR domain of APPL family DUF5136 PF17199.4 ORX59468.1 - 0.97 9.2 13.2 1.9 8.3 0.9 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF5136) Edc3_linker PF16598.5 ORX59468.1 - 1 10.1 14.1 11 6.8 3.4 2.2 1 1 1 2 2 2 0 Linker region of enhancer of mRNA-decapping protein 3 LSM_int_assoc PF16605.5 ORX59468.1 - 1.1 9.5 7.9 9.4 6.4 0.2 3.3 1 1 1 2 2 2 0 LSM-interacting associated unstructured Suf PF05843.14 ORX59468.1 - 4.2 7.3 18.5 4.8 7.1 18.5 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3487 PF11990.8 ORX59470.1 - 0.1 12.5 0.3 0.14 12.0 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3487) Fer4_2 PF12797.7 ORX59476.1 - 0.077 13.1 0.5 0.17 12.1 0.5 1.5 1 0 0 1 1 1 0 4Fe-4S binding domain Thioredoxin PF00085.20 ORX59477.1 - 1.4e-16 60.4 0.0 1.7e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ORX59477.1 - 2.3e-06 27.2 0.0 3.5e-06 26.6 0.0 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ORX59477.1 - 0.0077 16.7 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ORX59477.1 - 0.17 11.8 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 ORX59477.1 - 0.22 11.9 0.0 0.44 10.9 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin-like GalP_UDP_transf PF01087.22 ORX59478.1 - 5.5e-71 238.8 0.4 9e-71 238.1 0.4 1.3 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 ORX59478.1 - 2.8e-60 202.9 0.1 7.2e-60 201.5 0.1 1.6 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4921 PF16268.5 ORX59478.1 - 3.1e-05 23.0 1.3 0.0024 16.8 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4921) DcpS_C PF11969.8 ORX59478.1 - 0.01 16.3 0.3 0.019 15.4 0.3 1.5 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ORX59478.1 - 0.11 13.3 3.4 0.91 10.3 3.1 2.5 2 1 0 2 2 2 0 HIT domain Fungal_trans PF04082.18 ORX59479.1 - 7.2e-23 81.0 0.0 1.4e-21 76.7 0.0 2.2 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX59479.1 - 4.8e-08 33.0 8.4 9e-08 32.1 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FAA_hydro_N_2 PF18288.1 ORX59479.1 - 0.058 13.8 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 zf-C3HC4_3 PF13920.6 ORX59481.1 - 2.1e-07 30.7 8.4 6e-07 29.2 8.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BRE1 PF08647.11 ORX59481.1 - 3.3e-07 30.3 8.5 3.3e-07 30.3 8.5 5.4 4 1 2 6 6 6 1 BRE1 E3 ubiquitin ligase Prok-RING_4 PF14447.6 ORX59481.1 - 6.9e-06 25.8 7.2 1.6e-05 24.7 7.2 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ORX59481.1 - 1.1e-05 25.2 10.4 3.1e-05 23.7 10.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX59481.1 - 1.9e-05 24.5 10.5 7e-05 22.7 10.5 2.0 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ORX59481.1 - 3.3e-05 23.7 10.4 8.5e-05 22.3 10.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX59481.1 - 0.00076 19.8 10.5 0.0023 18.2 10.5 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX59481.1 - 0.0057 16.7 8.2 0.018 15.0 8.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Fzo_mitofusin PF04799.13 ORX59481.1 - 0.0062 16.1 1.8 0.0062 16.1 1.8 4.7 3 2 3 6 6 6 1 fzo-like conserved region CENP-F_leu_zip PF10473.9 ORX59481.1 - 0.014 15.4 7.5 0.014 15.4 7.5 5.8 3 2 1 5 5 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-rbx1 PF12678.7 ORX59481.1 - 0.016 15.5 5.1 0.016 15.5 5.1 2.2 2 0 0 2 2 1 0 RING-H2 zinc finger domain DZR PF12773.7 ORX59481.1 - 0.035 14.1 6.2 0.16 12.0 6.2 2.1 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_4 PF14570.6 ORX59481.1 - 0.044 13.6 6.3 0.11 12.3 6.3 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1272 PF06906.11 ORX59481.1 - 0.072 13.2 4.7 0.21 11.7 4.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-RING_6 PF14835.6 ORX59481.1 - 0.18 11.7 3.8 0.47 10.4 3.8 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ORX59481.1 - 0.19 11.9 6.8 0.66 10.2 6.8 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING SOBP PF15279.6 ORX59481.1 - 1 9.9 4.0 1.6 9.3 2.4 2.0 1 1 1 2 2 2 0 Sine oculis-binding protein zf-C3H2C3 PF17122.5 ORX59481.1 - 1.2 9.2 6.1 2.5 8.2 6.1 1.6 1 0 0 1 1 1 0 Zinc-finger Filament PF00038.21 ORX59481.1 - 3.3 7.2 48.1 10 5.6 7.3 4.7 2 2 2 4 4 4 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 ORX59481.1 - 6.9 6.7 48.2 1.8 8.7 3.7 5.5 5 2 0 5 5 5 0 TPR/MLP1/MLP2-like protein zf-ribbon_3 PF13248.6 ORX59481.1 - 7.3 6.1 6.8 17 5.0 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain PPR_3 PF13812.6 ORX59482.1 - 5.3e-19 68.1 0.1 0.00083 19.4 0.0 5.7 4 1 0 5 5 5 4 Pentatricopeptide repeat domain PPR_2 PF13041.6 ORX59482.1 - 7.5e-19 67.7 0.1 7.4e-06 26.1 0.0 6.7 4 2 3 7 7 7 7 PPR repeat family PPR_long PF17177.4 ORX59482.1 - 6.2e-18 64.9 2.2 4.4e-10 39.3 0.4 4.0 2 2 2 4 4 4 4 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ORX59482.1 - 7.4e-16 57.2 0.0 0.0036 17.4 0.0 6.6 6 0 0 6 6 6 4 PPR repeat PPR_1 PF12854.7 ORX59482.1 - 1.3e-06 28.0 2.0 0.0038 16.9 0.0 4.0 4 0 0 4 4 4 2 PPR repeat TPR_14 PF13428.6 ORX59482.1 - 1 10.3 12.1 11 7.1 0.4 6.1 4 3 3 7 7 7 0 Tetratricopeptide repeat Ipi1_N PF12333.8 ORX59483.1 - 0.13 12.8 4.2 8.1 7.1 0.1 4.9 5 0 0 5 5 5 0 Rix1 complex component involved in 60S ribosome maturation DEAD PF00270.29 ORX59484.1 - 2.8e-11 43.5 0.2 5.2e-08 32.9 0.1 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX59484.1 - 1.3e-09 38.3 0.0 2.4e-09 37.5 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 ORX59484.1 - 0.0012 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ORX59484.1 - 0.0068 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ORX59484.1 - 0.082 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Motile_Sperm PF00635.26 ORX59486.1 - 0.0024 17.7 0.0 0.016 15.0 0.0 2.1 2 1 0 2 2 2 1 MSP (Major sperm protein) domain PMM PF03332.13 ORX59487.1 - 3.2e-108 360.6 0.5 3.7e-108 360.4 0.5 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 ORX59487.1 - 0.0038 17.0 0.0 0.034 13.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CUE PF02845.16 ORX59487.1 - 0.033 13.9 1.4 4.7 7.0 0.0 3.3 3 0 0 3 3 3 0 CUE domain Trehalose_PPase PF02358.16 ORX59487.1 - 0.16 11.1 0.0 0.25 10.4 0.0 1.3 1 0 0 1 1 1 0 Trehalose-phosphatase HAD PF12710.7 ORX59487.1 - 0.16 12.3 0.1 4 7.8 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase START PF01852.19 ORX59488.1 - 2.9e-22 79.1 0.8 1.4e-12 47.5 0.1 2.2 2 0 0 2 2 2 2 START domain Glyco_hydro_5_C PF18564.1 ORX59488.1 - 5.4e-05 23.7 0.7 0.00015 22.3 0.1 2.1 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Pkinase PF00069.25 ORX59489.1 - 2.6e-55 187.7 0.1 3.1e-54 184.1 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59489.1 - 4e-33 114.8 0.0 5.4e-33 114.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX59489.1 - 8.5e-06 25.9 0.3 0.016 15.2 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX59489.1 - 1.9e-05 24.1 0.1 3.7e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX59489.1 - 5.4e-05 22.7 0.0 8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX59489.1 - 0.00014 20.9 0.1 0.00014 20.9 0.1 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ORX59489.1 - 0.0028 16.5 0.0 0.005 15.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX59489.1 - 0.003 17.1 0.0 0.0049 16.4 0.0 1.3 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL RIO1 PF01163.22 ORX59489.1 - 0.0093 15.6 0.1 0.015 14.9 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 ORX59489.1 - 0.076 12.6 0.2 0.16 11.6 0.2 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase WaaY PF06176.11 ORX59489.1 - 0.097 12.3 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide core biosynthesis protein (WaaY) eIF2A PF08662.11 ORX59490.1 - 1.9e-82 275.9 3.5 6.8e-80 267.5 0.0 3.0 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ORX59490.1 - 0.0014 19.4 0.8 19 6.3 0.0 4.4 4 0 0 4 4 4 1 WD domain, G-beta repeat Cys_box PF17869.1 ORX59490.1 - 0.084 13.0 0.2 0.17 12.0 0.2 1.4 1 0 0 1 1 1 0 Anosmin cysteine rich domain Glyco_transf_15 PF01793.16 ORX59491.1 - 1.4e-115 386.0 4.3 2.1e-115 385.5 4.3 1.2 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase FixH PF05751.11 ORX59491.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 FixH Glyco_transf_15 PF01793.16 ORX59492.1 - 4.9e-54 183.8 9.0 5.7e-54 183.5 9.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase VID27 PF08553.10 ORX59493.1 - 1.1e-64 218.8 0.0 7.8e-64 216.0 0.0 2.0 1 1 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 ORX59493.1 - 3.7e-17 62.7 0.1 3.7e-17 62.7 0.1 3.8 4 1 0 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 ORX59493.1 - 3.3e-16 59.5 3.1 6e-16 58.7 1.1 2.4 2 1 0 2 2 2 1 VID27 PH-like domain Evr1_Alr PF04777.13 ORX59494.1 - 8.8e-28 96.7 0.0 1.1e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 Erv1 / Alr family Arrestin_C PF02752.22 ORX59495.1 - 4.5e-17 62.8 8.4 5.4e-11 43.1 0.6 2.6 3 0 0 3 3 3 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX59495.1 - 5.5e-17 62.2 0.5 5.7e-14 52.4 0.2 3.3 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Vps26 PF03643.15 ORX59495.1 - 3.9e-05 22.8 0.4 0.0012 17.9 0.1 2.4 2 1 0 2 2 2 1 Vacuolar protein sorting-associated protein 26 Spo0M PF07070.11 ORX59495.1 - 0.00024 20.7 0.4 0.0035 16.9 0.0 2.1 2 0 0 2 2 2 1 SpoOM protein BUD22 PF09073.10 ORX59495.1 - 1.9 7.7 5.6 2.8 7.2 0.1 2.1 2 0 0 2 2 2 0 BUD22 CHORD PF04968.12 ORX59496.1 - 1.8e-53 179.1 22.3 3.2e-27 95.0 6.4 2.6 3 0 0 3 3 3 2 CHORD CS PF04969.16 ORX59496.1 - 2.7e-16 60.3 1.0 4.5e-16 59.6 1.0 1.4 1 0 0 1 1 1 1 CS domain Rieske PF00355.26 ORX59496.1 - 0.0052 16.7 4.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 2 Rieske [2Fe-2S] domain BTK PF00779.19 ORX59496.1 - 0.11 12.4 10.4 0.75 9.7 1.1 3.4 3 0 0 3 3 3 0 BTK motif DDE_3 PF13358.6 ORX59497.1 - 7.3e-05 22.6 0.1 0.00011 22.0 0.1 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF5637 PF18687.1 ORX59499.1 - 0.055 13.4 3.2 35 4.5 0.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5637) LydB PF16084.5 ORX59499.1 - 0.062 13.1 0.0 67 3.3 0.0 3.2 3 0 0 3 3 3 0 LydA-holin antagonist FdsD PF11390.8 ORX59499.1 - 0.69 10.3 10.1 19 5.7 0.4 3.2 3 0 0 3 3 3 0 NADH-dependant formate dehydrogenase delta subunit FdsD EcKinase PF02958.20 ORX59500.1 - 0.2 10.9 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase MLVIN_C PF18697.1 ORX59502.1 - 0.0011 19.0 0.8 0.0024 17.9 0.1 1.9 1 1 1 2 2 2 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Rot1 PF10681.9 ORX59502.1 - 0.085 12.4 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal EcKinase PF02958.20 ORX59504.1 - 0.2 10.9 0.0 0.23 10.7 0.0 1.1 1 0 0 1 1 1 0 Ecdysteroid kinase Fer4_2 PF12797.7 ORX59506.1 - 0.087 13.0 0.8 0.17 12.0 0.8 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain Peptidase_M11 PF05548.11 ORX59506.1 - 0.1 11.8 0.1 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Gametolysin peptidase M11 Fer4_2 PF12797.7 ORX59507.1 - 0.087 13.0 0.8 0.17 12.0 0.8 1.4 1 0 0 1 1 1 0 4Fe-4S binding domain Peptidase_M11 PF05548.11 ORX59507.1 - 0.1 11.8 0.1 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Gametolysin peptidase M11 Hydrophobin_2 PF06766.11 ORX59508.1 - 0.26 11.2 3.1 0.33 10.9 2.6 1.5 1 1 0 1 1 1 0 Fungal hydrophobin DUF3464 PF11947.8 ORX59510.1 - 3.3 7.5 5.4 4 7.2 5.4 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Tup_N PF08581.10 ORX59511.1 - 0.28 11.5 3.8 0.35 11.2 1.0 2.3 1 1 1 2 2 2 0 Tup N-terminal Ribosomal_S13 PF00416.22 ORX59514.1 - 2.1e-54 183.3 2.7 2.4e-54 183.1 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 ORX59514.1 - 0.0045 15.8 0.0 0.0045 15.8 0.0 1.1 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Nucleoporin_N PF08801.11 ORX59515.1 - 2.6e-49 168.1 0.0 3.7e-49 167.7 0.0 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Vps16_N PF04841.13 ORX59516.1 - 9.6e-09 34.5 0.0 9.6e-09 34.5 0.0 1.0 1 0 0 1 1 1 1 Vps16, N-terminal region Vps16_C PF04840.12 ORX59517.1 - 7.5e-82 274.9 3.4 8.4e-81 271.5 1.7 2.1 1 1 1 2 2 2 2 Vps16, C-terminal region Vps16_N PF04841.13 ORX59517.1 - 4.2e-67 226.7 0.0 6.1e-67 226.2 0.0 1.3 1 0 0 1 1 1 1 Vps16, N-terminal region ANAPC4_WD40 PF12894.7 ORX59517.1 - 0.13 12.6 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FAM86 PF14904.6 ORX59518.1 - 0.078 13.1 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function Vezatin PF12632.7 ORX59519.1 - 5.4e-05 22.7 2.1 9e-05 22.0 2.1 1.4 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes DUF2968 PF11180.8 ORX59519.1 - 0.0052 16.4 0.7 0.01 15.5 0.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) Med9 PF07544.13 ORX59519.1 - 0.16 12.0 1.1 18 5.5 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 COPI_assoc PF08507.10 ORX59520.1 - 1.2e-13 51.2 9.2 1.8e-13 50.7 9.2 1.1 1 0 0 1 1 1 1 COPI associated protein 7TM_GPCR_Sri PF10327.9 ORX59520.1 - 0.015 14.5 3.6 0.02 14.1 3.6 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri zf-C2H2 PF00096.26 ORX59522.1 - 1.2e-18 66.5 35.0 4.7e-06 26.8 0.9 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX59522.1 - 2.4e-18 65.7 22.1 3.5e-06 27.2 1.3 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX59522.1 - 6.9e-09 35.8 31.8 0.0035 18.0 0.6 4.4 4 1 1 5 5 5 4 C2H2-type zinc finger zf-TRAF PF02176.18 ORX59522.1 - 0.0053 17.4 11.2 0.01 16.5 2.7 3.0 2 1 1 3 3 3 1 TRAF-type zinc finger zf-C2H2_8 PF15909.5 ORX59522.1 - 0.0095 16.2 12.3 2.4 8.5 12.1 2.3 1 1 0 1 1 1 1 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX59522.1 - 0.052 14.2 1.0 0.052 14.2 1.0 3.2 2 2 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX59522.1 - 0.09 12.8 0.4 0.09 12.8 0.4 4.6 5 1 0 5 5 5 0 C2H2-type zinc finger zf_UBZ PF18439.1 ORX59522.1 - 0.23 11.1 5.7 1.5 8.5 0.1 3.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-C2HC_2 PF13913.6 ORX59522.1 - 0.29 11.1 11.7 1.7 8.7 0.4 3.4 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-met PF12874.7 ORX59522.1 - 0.51 10.8 0.1 0.51 10.8 0.1 4.3 5 0 0 5 5 5 0 Zinc-finger of C2H2 type ADK_lid PF05191.14 ORX59522.1 - 0.56 10.2 7.0 1.4 9.0 1.9 3.1 2 2 0 2 2 2 0 Adenylate kinase, active site lid zf-C2H2_aberr PF17017.5 ORX59522.1 - 0.84 9.8 14.8 14 5.8 5.5 3.6 1 1 1 3 3 3 0 Aberrant zinc-finger zf-CCHC PF00098.23 ORX59523.1 - 0.0057 16.7 5.0 0.0098 15.9 5.0 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ORX59523.1 - 0.0079 16.1 0.2 0.0097 15.9 0.2 1.2 1 0 0 1 1 1 1 Zinc knuckle eIF3g PF12353.8 ORX59523.1 - 0.32 11.4 1.3 0.42 11.0 1.3 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G zf-CCHC_5 PF14787.6 ORX59523.1 - 0.38 10.5 4.3 2.2 8.1 4.3 2.1 1 1 0 1 1 1 0 GAG-polyprotein viral zinc-finger Ham1p_like PF01725.16 ORX59524.1 - 1.5e-57 194.6 0.0 1.6e-57 194.4 0.0 1.0 1 0 0 1 1 1 1 Ham1 family Kinetochor_Ybp2 PF08568.10 ORX59525.1 - 8.3e-18 64.2 0.5 1e-17 63.9 0.5 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin SopA PF13981.6 ORX59525.1 - 0.061 13.8 0.4 0.16 12.4 0.4 1.7 1 1 0 1 1 1 0 SopA-like central domain Zn_Tnp_IS1595 PF12760.7 ORX59527.1 - 0.0012 18.8 3.4 0.0015 18.5 0.9 2.1 2 0 0 2 2 2 1 Transposase zinc-ribbon domain zinc_ribbon_10 PF10058.9 ORX59527.1 - 0.013 15.3 1.8 0.039 13.7 0.5 2.3 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Zn-ribbon_8 PF09723.10 ORX59527.1 - 0.018 15.2 7.0 2.7 8.2 0.0 3.4 3 1 0 3 3 3 0 Zinc ribbon domain Cytochrome_C7 PF14522.6 ORX59527.1 - 0.04 13.9 2.5 0.058 13.4 1.0 1.9 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c PhnA_Zn_Ribbon PF08274.12 ORX59527.1 - 0.16 12.0 6.5 11 6.1 0.3 3.3 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DNA_RNApol_7kD PF03604.13 ORX59527.1 - 0.83 9.4 3.7 7.5 6.3 0.7 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 ORX59527.1 - 1.8 8.6 5.5 19 5.3 5.5 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rubredoxin_2 PF18073.1 ORX59527.1 - 2.7 7.8 0.0 2.7 7.8 0.0 3.0 3 0 0 3 3 3 0 Rubredoxin metal binding domain DZR PF12773.7 ORX59527.1 - 4.2 7.5 10.3 23 5.1 10.3 2.2 1 1 0 1 1 1 0 Double zinc ribbon Pkinase_Tyr PF07714.17 ORX59528.1 - 4.3e-47 160.6 0.0 4.9e-47 160.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ORX59528.1 - 1.1e-41 142.9 0.0 1.5e-41 142.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Haspin_kinase PF12330.8 ORX59528.1 - 0.02 13.9 0.0 0.03 13.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pyr_redox_2 PF07992.14 ORX59529.1 - 1.2e-31 110.0 0.0 1.5e-31 109.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX59529.1 - 9.4e-14 51.7 0.1 3.7e-09 37.0 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX59529.1 - 3.3e-10 39.7 0.0 2e-05 24.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX59529.1 - 1.2e-08 34.9 0.4 9e-05 22.2 0.4 2.5 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX59529.1 - 1.2e-06 28.9 0.0 0.0034 17.8 0.0 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding NAD_binding_8 PF13450.6 ORX59529.1 - 1.2e-06 28.6 0.3 0.0024 18.1 0.2 2.5 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ORX59529.1 - 1.6e-06 28.2 0.2 0.066 13.2 0.1 3.8 4 0 0 4 4 4 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 ORX59529.1 - 4.2e-06 26.1 0.2 0.00039 19.7 0.1 2.5 2 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 ORX59529.1 - 1e-05 24.6 0.6 0.0023 16.8 0.1 2.4 3 0 0 3 3 3 2 Tryptophan halogenase Lycopene_cycl PF05834.12 ORX59529.1 - 4.5e-05 22.7 0.1 0.07 12.2 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein TrkA_N PF02254.18 ORX59529.1 - 0.00012 22.4 1.1 0.45 10.8 0.2 3.1 3 0 0 3 3 3 2 TrkA-N domain HI0933_like PF03486.14 ORX59529.1 - 0.00019 20.3 0.4 0.17 10.6 0.1 2.3 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.17 ORX59529.1 - 0.00044 19.6 0.1 0.096 11.9 0.1 2.3 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 ORX59529.1 - 0.00058 19.1 0.1 1.5 7.8 0.2 3.1 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ORX59529.1 - 0.002 17.5 2.7 0.45 9.7 0.2 2.6 3 0 0 3 3 3 2 FAD binding domain DUF4147 PF13660.6 ORX59529.1 - 0.0031 17.1 0.0 1.2 8.7 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4147) Sacchrp_dh_NADP PF03435.18 ORX59529.1 - 0.0038 17.5 0.7 1.1 9.5 0.3 2.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain FAD_binding_2 PF00890.24 ORX59529.1 - 0.025 13.7 0.7 0.92 8.5 0.3 2.6 2 1 1 3 3 3 0 FAD binding domain FAD_oxidored PF12831.7 ORX59529.1 - 0.028 13.8 0.1 4.2 6.6 0.1 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase DUF1188 PF06690.11 ORX59529.1 - 0.2 11.2 0.0 8.1 5.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) UDPG_MGDP_dh_N PF03721.14 ORX59529.1 - 0.21 11.2 0.6 0.57 9.7 0.3 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Shikimate_DH PF01488.20 ORX59529.1 - 0.47 10.5 1.5 20 5.2 0.3 2.6 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase TPR_19 PF14559.6 ORX59531.1 - 0.047 14.2 0.1 0.11 13.0 0.1 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat RRM_1 PF00076.22 ORX59532.1 - 8.4e-18 64.0 0.0 9.1e-12 44.6 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX59532.1 - 0.067 13.3 0.0 1.5 9.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif PRK PF00485.18 ORX59533.1 - 1.9e-30 106.1 0.0 2.3e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ORX59533.1 - 9.6e-05 22.9 0.0 0.00022 21.7 0.0 1.5 2 0 0 2 2 2 1 AAA domain 4HBT_3 PF13622.6 ORX59534.1 - 2.7e-25 90.0 0.2 4.2e-25 89.5 0.1 1.3 2 0 0 2 2 2 1 Thioesterase-like superfamily zf-C2H2 PF00096.26 ORX59535.1 - 1.5e-05 25.2 26.2 8.2e-05 22.8 2.8 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ORX59535.1 - 0.0026 18.0 2.1 0.012 15.9 0.4 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 ORX59535.1 - 0.0034 17.7 4.3 0.0034 17.7 4.3 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX59535.1 - 0.0095 16.7 2.0 0.0095 16.7 2.0 4.0 4 0 0 4 4 4 1 C2H2-type zinc finger FOXP-CC PF16159.5 ORX59535.1 - 0.05 14.2 0.1 0.05 14.2 0.1 3.8 2 1 2 4 4 4 0 FOXP coiled-coil domain zf_ZIC PF18366.1 ORX59535.1 - 0.052 13.7 0.0 0.052 13.7 0.0 2.8 3 0 0 3 3 3 0 Zic proteins zinc finger domain zf-met PF12874.7 ORX59535.1 - 0.66 10.4 4.9 7.2 7.1 0.5 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 ORX59535.1 - 4.5 7.4 8.1 7.6 6.6 8.1 1.4 1 0 0 1 1 1 0 Aberrant zinc-finger Zap1_zf2 PF18217.1 ORX59535.1 - 4.8 7.3 8.4 3.6 7.7 0.4 2.5 2 0 0 2 2 2 0 Zap1 zinc finger 2 AMP-binding PF00501.28 ORX59536.1 - 3.5e-75 253.2 0.0 4.2e-75 252.9 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX59536.1 - 3.2e-08 34.4 0.0 6.5e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain LSM PF01423.22 ORX59537.1 - 1.1e-15 57.1 0.2 1.4e-15 56.7 0.2 1.2 1 0 0 1 1 1 1 LSM domain DUF5440 PF17509.2 ORX59537.1 - 0.05 13.2 0.0 0.1 12.2 0.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5440) Asparaginase_2 PF01112.18 ORX59538.1 - 7.9e-56 189.3 5.8 1.2e-55 188.7 5.8 1.2 1 1 0 1 1 1 1 Asparaginase Asp PF00026.23 ORX59539.1 - 1.5e-63 215.1 7.7 1.8e-63 214.8 7.7 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX59539.1 - 3.5e-13 50.2 1.5 1.4e-07 31.9 0.1 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX59539.1 - 0.0095 16.6 1.7 10 6.8 0.1 3.4 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX59539.1 - 0.061 13.9 0.9 21 5.8 0.1 3.2 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease IATP PF04568.12 ORX59539.1 - 1.9 8.9 3.9 5.3 7.5 3.9 1.7 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Asp PF00026.23 ORX59540.1 - 1.3e-64 218.6 2.8 1.6e-64 218.3 2.8 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX59540.1 - 4.8e-12 46.5 5.0 6.2e-08 33.1 0.2 3.7 3 1 1 4 4 4 3 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ORX59540.1 - 0.0037 17.1 0.0 0.011 15.6 0.0 1.8 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 ORX59540.1 - 0.0053 17.4 3.9 0.88 10.3 0.2 3.6 3 2 0 3 3 3 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX59540.1 - 0.0062 17.1 2.2 8.6 7.0 0.2 3.6 2 2 0 2 2 2 2 gag-polyprotein putative aspartyl protease ILVD_EDD PF00920.21 ORX59541.1 - 5.5e-215 714.9 0.1 6.4e-215 714.6 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family DHO_dh PF01180.21 ORX59542.1 - 7e-62 209.3 0.0 8.1e-62 209.1 0.0 1.0 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 ORX59542.1 - 0.12 11.4 0.1 0.18 10.8 0.1 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase zf-C2H2_2 PF12756.7 ORX59543.1 - 0.0035 17.6 1.1 0.02 15.2 1.1 2.3 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 ORX59543.1 - 0.0052 16.6 1.8 0.087 12.7 0.2 2.7 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) zf-Di19 PF05605.12 ORX59543.1 - 0.0089 16.3 8.7 0.16 12.3 0.3 3.1 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding Ima1_N PF09779.9 ORX59543.1 - 0.32 11.8 2.5 15 6.5 0.1 2.6 1 1 1 2 2 2 0 Ima1 N-terminal domain FOXP-CC PF16159.5 ORX59543.1 - 2.4 8.9 5.4 2.3 8.9 0.1 3.1 3 0 0 3 3 3 0 FOXP coiled-coil domain zf-C2H2 PF00096.26 ORX59543.1 - 2.7 8.6 5.7 21 5.8 2.5 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type PHD PF00628.29 ORX59545.1 - 1.1e-08 34.8 2.8 3.4e-08 33.2 2.8 1.9 1 0 0 1 1 1 1 PHD-finger zf-CpG_bind_C PF12269.8 ORX59545.1 - 0.00013 21.8 0.2 0.00013 21.8 0.2 2.7 1 1 2 3 3 3 1 CpG binding protein zinc finger C terminal domain PHD_2 PF13831.6 ORX59545.1 - 0.02 14.4 1.3 0.02 14.4 1.3 2.4 2 0 0 2 2 2 0 PHD-finger zf-RING_9 PF13901.6 ORX59545.1 - 1 9.3 9.7 0.42 10.6 0.8 2.8 2 1 0 2 2 2 0 Putative zinc-RING and/or ribbon Peptidase_S8 PF00082.22 ORX59546.1 - 1.8e-40 139.1 0.0 2.8e-40 138.4 0.0 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 ORX59546.1 - 1.1e-26 92.7 0.7 2.4e-26 91.6 0.7 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain DUF4746 PF15928.5 ORX59546.1 - 0.18 11.2 6.3 0.27 10.6 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TFIIF_alpha PF05793.12 ORX59546.1 - 2 6.9 7.6 2.9 6.4 7.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mito_fiss_Elm1 PF06258.11 ORX59547.1 - 1.2e-21 77.2 0.0 1.5e-21 76.9 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial fission ELM1 DRTGG PF07085.12 ORX59547.1 - 0.14 11.9 0.0 0.78 9.6 0.0 2.1 2 0 0 2 2 2 0 DRTGG domain Perilipin PF03036.16 ORX59548.1 - 7e-05 22.0 8.6 0.0025 16.9 0.1 2.8 1 1 1 2 2 2 2 Perilipin family TAFH PF07531.14 ORX59548.1 - 0.094 12.8 1.3 1.3 9.2 0.1 3.0 2 1 0 2 2 2 0 NHR1 homology to TAF CRR7 PF12095.8 ORX59548.1 - 0.13 12.7 1.0 0.55 10.7 0.7 2.2 1 1 0 1 1 1 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF5082 PF16888.5 ORX59548.1 - 0.38 11.0 4.0 0.24 11.7 1.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) ZapB PF06005.12 ORX59548.1 - 2.9 8.4 7.6 0.2 12.1 1.1 2.5 3 0 0 3 3 3 0 Cell division protein ZapB Apolipoprotein PF01442.18 ORX59548.1 - 4.5 7.1 9.2 1.3 8.9 2.3 3.0 1 1 2 3 3 3 0 Apolipoprotein A1/A4/E domain PRKCSH-like PF12999.7 ORX59549.1 - 5.8e-49 166.3 5.8 5.8e-49 166.3 5.8 1.8 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 ORX59549.1 - 1.8e-28 99.1 2.6 2.3e-28 98.8 0.1 2.2 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 ORX59549.1 - 0.00023 22.1 1.9 0.00043 21.2 0.3 2.4 2 1 0 2 2 2 1 Glucosidase II beta subunit-like protein Dynamitin PF04912.14 ORX59549.1 - 0.017 14.5 4.2 0.02 14.2 1.9 1.9 2 0 0 2 2 2 0 Dynamitin ALS2CR8 PF15299.6 ORX59549.1 - 0.026 14.4 0.2 0.035 14.0 0.2 1.3 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 DivIC PF04977.15 ORX59549.1 - 0.036 13.8 9.8 0.45 10.3 0.0 2.9 4 0 0 4 4 2 0 Septum formation initiator WXG100 PF06013.12 ORX59549.1 - 0.038 14.2 0.7 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Proteins of 100 residues with WXG CENP-F_leu_zip PF10473.9 ORX59549.1 - 0.052 13.6 6.3 0.18 11.9 2.7 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.17 ORX59549.1 - 0.099 12.6 0.9 15 5.5 0.1 2.5 2 0 0 2 2 2 0 Prefoldin subunit RasGAP PF00616.19 ORX59549.1 - 0.12 12.0 1.1 0.24 11.1 1.1 1.4 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase NPV_P10 PF05531.12 ORX59549.1 - 0.13 12.8 0.9 6.5 7.3 0.0 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 ORX59549.1 - 0.13 12.6 2.7 5.9 7.4 0.4 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HeLo PF14479.6 ORX59549.1 - 0.19 11.5 4.1 0.34 10.7 2.2 2.0 2 0 0 2 2 2 0 Prion-inhibition and propagation Atg14 PF10186.9 ORX59549.1 - 0.28 10.2 5.4 0.17 11.0 2.2 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GrpE PF01025.19 ORX59549.1 - 0.33 10.6 6.6 0.09 12.4 0.5 2.7 2 1 0 3 3 3 0 GrpE Bacillus_HBL PF05791.11 ORX59549.1 - 0.39 10.5 4.7 0.17 11.7 0.4 2.1 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DUF5320 PF17253.2 ORX59549.1 - 0.57 11.3 2.3 5.3 8.2 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) LPP PF04728.13 ORX59549.1 - 0.65 10.4 3.8 5.3 7.5 0.2 2.4 2 0 0 2 2 2 0 Lipoprotein leucine-zipper Muted PF14942.6 ORX59549.1 - 2.3 8.6 9.2 0.97 9.8 2.5 2.8 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein BLOC1_2 PF10046.9 ORX59549.1 - 3.2 8.1 5.2 8.4 6.8 0.8 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4407 PF14362.6 ORX59549.1 - 4.1 6.7 10.8 3.2 7.0 6.9 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Ldl_recept_a PF00057.18 ORX59549.1 - 7.6 6.8 16.2 1.3 9.3 3.8 2.9 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A Abhydrolase_1 PF00561.20 ORX59550.1 - 2.8e-18 66.5 0.3 1.5e-17 64.1 0.3 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 ORX59550.1 - 1.1e-17 63.3 0.0 2.1e-17 62.4 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 ORX59550.1 - 0.0023 17.2 0.0 0.21 10.8 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 KCH PF16944.5 ORX59551.1 - 4e-76 256.1 20.2 4.8e-76 255.9 20.2 1.1 1 0 0 1 1 1 1 Fungal potassium channel TFIIA PF03153.13 ORX59551.1 - 2.2 8.2 19.0 2.7 7.9 19.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FH2 PF02181.23 ORX59552.1 - 7.5e-71 239.2 12.1 8.6e-71 239.0 10.2 2.0 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ORX59552.1 - 2.9e-38 131.3 0.0 1.4e-37 129.1 0.0 2.2 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX59552.1 - 1.2e-27 96.8 0.5 5e-27 94.8 0.0 2.4 2 0 0 2 2 2 1 Diaphanous FH3 Domain RIBIOP_C PF04950.12 ORX59552.1 - 0.069 12.6 0.2 0.17 11.3 0.2 1.6 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Drf_FH1 PF06346.12 ORX59552.1 - 3.5 7.3 164.2 0.077 12.7 89.6 2.6 1 1 1 2 2 2 0 Formin Homology Region 1 CBFD_NFYB_HMF PF00808.23 ORX59553.1 - 9e-30 102.8 0.6 1.3e-29 102.2 0.6 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX59553.1 - 4.6e-06 27.0 0.4 7.7e-06 26.3 0.1 1.5 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ORX59553.1 - 0.00075 19.6 0.0 0.0011 19.0 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID-18kDa PF02269.16 ORX59553.1 - 0.0039 17.2 0.0 0.0064 16.5 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CENP-X PF09415.10 ORX59553.1 - 0.015 15.6 0.6 0.024 14.9 0.1 1.6 2 0 0 2 2 2 0 CENP-S associating Centromere protein X Bromo_TP PF07524.13 ORX59553.1 - 0.072 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated Pribosyltran PF00156.27 ORX59554.1 - 1.3e-12 47.5 0.1 3.7e-12 46.0 0.0 1.6 1 1 0 2 2 2 1 Phosphoribosyl transferase domain PA PF02225.22 ORX59554.1 - 0.018 15.1 0.6 0.028 14.4 0.6 1.3 1 0 0 1 1 1 0 PA domain PRTase_2 PF15609.6 ORX59554.1 - 0.22 11.0 0.9 0.39 10.2 0.5 1.6 1 1 1 2 2 2 0 Phosphoribosyl transferase Na_H_Exchanger PF00999.21 ORX59556.1 - 5.8e-40 137.3 37.1 8.6e-40 136.7 37.1 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Metallophos PF00149.28 ORX59557.1 - 3.6e-13 50.5 2.6 5.6e-13 49.9 2.6 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PRCC PF10253.9 ORX59558.1 - 0.011 16.5 6.1 0.011 16.5 6.1 2.6 2 1 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting Podoplanin PF05808.11 ORX59558.1 - 0.096 12.8 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Podoplanin DAP10 PF07213.11 ORX59558.1 - 0.12 12.3 0.7 0.23 11.4 0.7 1.4 1 0 0 1 1 1 0 DAP10 membrane protein EphA2_TM PF14575.6 ORX59558.1 - 0.22 12.4 4.9 1.2 10.0 4.9 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain zf-CCCH_4 PF18044.1 ORX59559.1 - 9.6e-09 34.8 4.3 1.8e-08 34.0 4.3 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX59559.1 - 1.3e-06 28.2 8.1 2.4e-06 27.4 8.1 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ORX59559.1 - 1.5e-05 24.8 3.3 2.4e-05 24.1 3.3 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) NupH_GANP PF16768.5 ORX59559.1 - 0.00016 21.5 94.5 0.0018 18.0 30.9 4.1 1 1 3 4 4 4 4 Nucleoporin homology of Germinal-centre associated nuclear protein Torus PF16131.5 ORX59559.1 - 0.03 15.0 0.9 0.066 13.9 0.9 1.5 1 0 0 1 1 1 0 Torus domain zf-CCCH_3 PF15663.5 ORX59559.1 - 0.04 14.1 0.1 0.083 13.1 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 ORX59559.1 - 0.097 13.2 1.8 0.16 12.5 1.8 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger CUE PF02845.16 ORX59560.1 - 4.2e-10 39.1 0.0 7.3e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 CUE domain Cue1_U7BR PF18499.1 ORX59560.1 - 0.0013 18.7 4.0 0.064 13.3 2.4 2.8 2 1 0 2 2 2 1 Ubc7p-binding region of Cue1 FNIP_N PF14636.6 ORX59560.1 - 0.071 14.1 3.1 0.09 13.8 3.1 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein N-terminus PP2C PF00481.21 ORX59561.1 - 1.5e-10 41.2 0.0 0.01 15.5 0.0 4.9 4 1 0 4 4 4 4 Protein phosphatase 2C DGF-1_C PF11040.8 ORX59561.1 - 0.31 11.1 2.6 1.4 8.9 2.6 2.2 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2834 PF11196.8 ORX59562.1 - 2.2e-09 37.5 26.4 1.9e-05 24.9 5.4 3.5 2 1 0 2 2 2 2 Protein of unknown function (DUF2834) Glycos_transf_2 PF00535.26 ORX59563.1 - 7e-35 120.3 0.0 8.4e-35 120.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ORX59563.1 - 4.1e-09 36.7 0.0 7.1e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ORX59563.1 - 1.1e-06 28.4 0.0 1.6e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ORX59563.1 - 0.012 15.0 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 ORX59563.1 - 0.14 12.7 0.0 0.28 11.7 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 Glyco_transf_7N PF13733.6 ORX59563.1 - 0.16 11.6 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 N-terminal region of glycosyl transferase group 7 Kelch_5 PF13854.6 ORX59564.1 - 1.3e-05 25.0 0.5 0.012 15.5 0.0 3.1 2 1 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ORX59564.1 - 0.00024 21.3 1.6 0.0011 19.3 0.3 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ORX59564.1 - 0.00046 20.1 3.1 0.93 9.6 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Rab3-GTPase_cat PF13890.6 ORX59565.1 - 3.7e-53 179.5 3.3 6.4e-53 178.7 3.3 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit UAA PF08449.11 ORX59566.1 - 2.8e-51 174.5 16.7 3.2e-51 174.3 16.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX59566.1 - 2.4e-10 40.7 18.3 4e-08 33.5 6.7 2.8 2 1 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX59566.1 - 0.011 14.9 0.6 0.011 14.9 0.6 2.3 2 1 0 2 2 2 0 Nucleotide-sugar transporter DUF1003 PF06210.11 ORX59566.1 - 0.071 13.2 0.5 0.26 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) DUF2600 PF10776.9 ORX59566.1 - 0.15 10.9 0.2 0.22 10.3 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2600) Snf7 PF03357.21 ORX59567.1 - 2.2e-11 43.6 9.8 3.3e-11 43.1 9.8 1.2 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 ORX59567.1 - 0.085 13.3 12.0 1.1 9.8 5.9 2.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein p450 PF00067.22 ORX59568.1 - 4.4e-87 292.8 0.0 6.2e-87 292.3 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 ORX59568.1 - 3.4e-25 88.9 0.0 5.6e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX59568.1 - 4.5e-19 69.1 1.3 9.8e-18 64.7 0.4 2.7 2 1 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 ORX59568.1 - 2.6e-11 44.1 0.0 5.5e-11 43.1 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain C2 PF00168.30 ORX59569.1 - 1.4e-18 67.0 0.0 5.2e-18 65.2 0.0 1.9 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 ORX59569.1 - 2.3e-18 66.8 4.5 3.9e-10 40.1 2.6 2.7 1 1 1 2 2 2 2 Munc13 (mammalian uncoordinated) homology domain DUF810 PF05664.11 ORX59569.1 - 2.2e-12 46.4 0.2 1.2e-08 34.0 0.2 2.3 2 0 0 2 2 2 2 Plant family of unknown function (DUF810) Clat_adaptor_s PF01217.20 ORX59570.1 - 1.7e-53 180.4 2.5 2e-53 180.2 2.5 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain SPO22 PF08631.10 ORX59570.1 - 0.1 12.0 0.1 0.21 11.1 0.1 1.4 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Septin PF00735.18 ORX59571.1 - 2.5e-53 181.2 0.8 4.3e-38 131.2 0.5 2.3 2 0 0 2 2 2 2 Septin AAA_16 PF13191.6 ORX59571.1 - 1.3e-05 25.6 0.1 3.8e-05 24.1 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 ORX59571.1 - 1.7e-05 24.9 0.0 3.3e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ORX59571.1 - 0.00038 19.7 0.2 0.00064 19.0 0.2 1.3 1 0 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 ORX59571.1 - 0.0016 18.4 1.8 0.24 11.3 0.2 2.7 2 1 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 ORX59571.1 - 0.0021 17.6 0.1 0.0045 16.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 ORX59571.1 - 0.006 16.0 0.1 0.03 13.7 0.0 1.9 2 0 0 2 2 2 1 FtsK/SpoIIIE family CLP1_P PF16575.5 ORX59571.1 - 0.0072 16.1 0.0 0.23 11.2 0.0 2.4 1 1 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop TniB PF05621.11 ORX59571.1 - 0.0091 15.4 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 Bacterial TniB protein AAA_5 PF07728.14 ORX59571.1 - 0.0091 16.0 0.0 0.028 14.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ORX59571.1 - 0.018 15.5 0.4 0.046 14.2 0.4 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ORX59571.1 - 0.018 14.8 0.1 0.048 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ORX59571.1 - 0.019 15.2 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX59571.1 - 0.02 14.6 0.1 0.046 13.4 0.0 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 ORX59571.1 - 0.021 15.0 0.1 0.061 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ORX59571.1 - 0.025 14.1 0.1 0.86 9.1 0.0 2.5 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_32 PF13654.6 ORX59571.1 - 0.026 13.3 0.7 1.6 7.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ORX59571.1 - 0.029 14.6 0.2 0.062 13.5 0.2 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ORX59571.1 - 0.03 14.6 0.6 0.14 12.4 0.6 2.2 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX59571.1 - 0.032 14.2 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ORX59571.1 - 0.048 14.0 0.1 0.092 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX59571.1 - 0.048 13.6 1.1 0.094 12.6 0.0 2.1 2 0 0 2 2 1 0 NACHT domain Dynamin_N PF00350.23 ORX59571.1 - 0.051 13.6 0.2 0.47 10.5 0.0 2.3 1 1 1 2 2 2 0 Dynamin family RNA_helicase PF00910.22 ORX59571.1 - 0.053 13.9 0.6 0.17 12.3 0.0 2.2 2 0 0 2 2 1 0 RNA helicase DUF815 PF05673.13 ORX59571.1 - 0.056 12.6 0.0 0.11 11.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 ORX59571.1 - 0.063 13.8 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 ORX59571.1 - 0.086 12.6 0.6 6.3 6.5 0.1 2.6 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein Ras PF00071.22 ORX59571.1 - 0.093 12.3 0.3 0.24 11.0 0.2 1.8 1 1 0 1 1 1 0 Ras family NTPase_1 PF03266.15 ORX59571.1 - 0.23 11.4 1.1 3.8 7.4 0.1 2.7 3 0 0 3 3 3 0 NTPase ATPase PF06745.13 ORX59571.1 - 0.92 8.8 3.2 0.66 9.3 0.9 2.1 2 1 0 2 2 2 0 KaiC RIX1 PF08167.12 ORX59572.1 - 3.1e-45 154.2 2.5 3.1e-45 154.2 2.5 2.3 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis Rotamase PF00639.21 ORX59572.1 - 0.51 11.3 2.0 0.61 11.1 0.1 2.1 2 0 0 2 2 2 0 PPIC-type PPIASE domain WRKY PF03106.15 ORX59573.1 - 2.5e-10 40.4 2.7 4.3e-10 39.7 2.7 1.3 1 0 0 1 1 1 1 WRKY DNA -binding domain NRIP1_repr_2 PF15688.5 ORX59573.1 - 0.0024 17.8 0.5 0.0044 17.0 0.5 1.4 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 2 Peptidase_S10 PF00450.22 ORX59574.1 - 6.8e-92 309.0 0.1 8.5e-92 308.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1664 PF07889.12 ORX59575.1 - 0.073 13.1 0.1 0.085 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Flagellar_rod PF05149.12 ORX59575.1 - 0.08 12.4 0.1 0.094 12.2 0.1 1.0 1 0 0 1 1 1 0 Paraflagellar rod protein GATA PF00320.27 ORX59576.1 - 5.5e-17 61.1 2.6 7.2e-17 60.7 2.6 1.2 1 0 0 1 1 1 1 GATA zinc finger TF_Zn_Ribbon PF08271.12 ORX59576.1 - 0.0039 16.7 0.4 0.0064 16.0 0.4 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Auto_anti-p27 PF06677.12 ORX59576.1 - 0.0039 17.3 0.5 0.0054 16.9 0.5 1.2 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 ORX59576.1 - 0.058 13.4 2.8 0.74 9.9 3.1 2.0 1 1 1 2 2 2 0 Double zinc ribbon TDP43_N PF18694.1 ORX59576.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 1 1 2 2 2 0 Transactive response DNA-binding protein N-terminal domain Pkinase PF00069.25 ORX59577.1 - 5.2e-45 153.9 0.0 1.3e-23 83.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59577.1 - 2.9e-22 79.2 0.0 4.8e-12 45.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ORX59577.1 - 0.00026 21.0 0.0 0.00055 19.9 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX59577.1 - 0.088 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase ABC2_membrane_3 PF12698.7 ORX59578.1 - 0.0021 17.2 0.1 0.0021 17.2 0.1 1.9 2 0 0 2 2 2 1 ABC-2 family transporter protein IspA PF04279.15 ORX59579.1 - 3.3 7.9 13.1 0.11 12.6 4.5 2.1 2 0 0 2 2 2 0 Intracellular septation protein A ASF1_hist_chap PF04729.13 ORX59580.1 - 1.5e-69 232.8 0.2 1.9e-69 232.5 0.2 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone Ribosomal_L26 PF16906.5 ORX59581.1 - 2.7e-38 130.3 4.4 3.7e-38 129.9 4.4 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ORX59581.1 - 4.7e-10 39.1 4.3 4.7e-10 39.1 4.3 1.9 2 0 0 2 2 2 1 KOW motif WD40 PF00400.32 ORX59582.1 - 5.9e-10 39.6 13.6 0.02 15.7 0.1 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Dynein_IC2 PF11540.8 ORX59582.1 - 0.0013 18.7 0.0 0.0013 18.7 0.0 2.6 3 0 0 3 3 3 1 Cytoplasmic dynein 1 intermediate chain 2 ANAPC4_WD40 PF12894.7 ORX59582.1 - 0.15 12.3 0.1 1.6 9.1 0.0 2.7 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4355 PF14265.6 ORX59582.1 - 1.4 9.1 17.3 2.9 8.2 8.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4355) Avl9 PF09794.9 ORX59583.1 - 2.5e-135 451.0 0.0 3.3e-135 450.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein Avl9 SPA PF08616.10 ORX59583.1 - 5.2e-12 45.7 0.0 4.3e-06 26.7 0.0 2.6 2 0 0 2 2 2 2 Stabilization of polarity axis DUF2347 PF09804.9 ORX59583.1 - 4e-09 36.5 1.6 0.0038 16.8 1.1 3.8 3 1 1 4 4 4 2 Uncharacterized conserved protein (DUF2347) DENN PF02141.21 ORX59583.1 - 0.00032 20.7 0.9 0.094 12.7 0.2 3.4 3 1 1 4 4 4 1 DENN (AEX-3) domain Afi1 PF07792.12 ORX59583.1 - 0.0091 16.5 0.1 0.018 15.6 0.1 1.4 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4504 PF14953.6 ORX59584.1 - 1.7e-09 37.5 0.5 5.3e-09 35.9 0.5 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4504) ThiF PF00899.21 ORX59587.1 - 1.2e-68 231.2 0.8 7.4e-68 228.5 0.0 2.0 2 0 0 2 2 2 1 ThiF family UBA_e1_thiolCys PF10585.9 ORX59587.1 - 3.9e-10 40.1 4.3 1.2e-06 28.6 0.0 3.0 4 0 0 4 4 4 2 Ubiquitin-activating enzyme active site UAE_UbL PF14732.6 ORX59587.1 - 4.2e-10 40.1 1.3 4.2e-10 40.1 1.3 2.3 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain NAD_binding_7 PF13241.6 ORX59587.1 - 8.3e-05 23.0 0.2 0.00031 21.1 0.1 2.0 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 ORX59587.1 - 0.00012 22.1 0.1 0.0004 20.4 0.1 1.9 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ORX59587.1 - 0.017 15.4 0.7 0.017 15.4 0.7 3.1 3 2 0 3 3 3 0 Saccharopine dehydrogenase NADP binding domain UDPG_MGDP_dh_N PF03721.14 ORX59587.1 - 0.018 14.6 1.0 0.23 11.0 0.1 2.7 3 0 0 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TrkA_N PF02254.18 ORX59587.1 - 0.083 13.2 0.4 0.35 11.1 0.1 2.3 3 0 0 3 3 3 0 TrkA-N domain AhpC-TSA PF00578.21 ORX59588.1 - 4.6e-21 75.0 0.0 6.1e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX59588.1 - 3e-07 30.2 0.0 4.2e-07 29.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin LAG1-DNAbind PF09271.11 ORX59589.1 - 3.2e-40 138.2 0.2 6.3e-40 137.3 0.2 1.5 1 0 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ORX59589.1 - 2.1e-21 76.8 0.0 3.2e-20 72.9 0.0 2.4 1 1 0 1 1 1 1 Beta-trefoil DNA-binding domain FAM176 PF14851.6 ORX59590.1 - 3.7 7.2 10.3 0.45 10.2 0.1 3.1 3 0 0 3 3 3 0 FAM176 family CoA_transf_3 PF02515.17 ORX59591.1 - 4.5e-38 131.3 2.9 3.8e-35 121.7 0.1 2.3 2 0 0 2 2 2 2 CoA-transferase family III F-box PF00646.33 ORX59592.1 - 1.7e-07 30.9 0.6 8.7e-07 28.7 0.0 2.5 2 1 0 2 2 2 1 F-box domain F-box-like PF12937.7 ORX59592.1 - 6e-07 29.3 0.6 6e-07 29.3 0.6 2.3 2 0 0 2 2 2 1 F-box-like Mak10 PF04112.13 ORX59592.1 - 0.041 13.4 1.0 0.056 13.0 0.1 1.6 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase RAI16-like PF10257.9 ORX59594.1 - 1.8e-51 175.2 0.0 4.3e-51 173.9 0.0 1.7 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Tir_receptor_C PF07489.11 ORX59594.1 - 0.089 12.8 3.1 0.19 11.7 3.1 1.5 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Exonuc_VII_L PF02601.15 ORX59595.1 - 0.15 11.6 3.0 0.22 11.1 3.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit G-alpha PF00503.20 ORX59596.1 - 2.5e-110 369.0 3.3 3e-110 368.7 3.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX59596.1 - 4.6e-14 52.2 0.6 1e-08 34.9 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ORX59596.1 - 5.7e-05 23.3 0.1 0.41 10.9 0.0 2.7 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX59596.1 - 0.00055 19.3 3.9 0.027 13.8 0.1 3.1 3 0 0 3 3 3 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ORX59596.1 - 0.0066 16.0 0.0 0.99 8.9 0.0 2.4 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain TniB PF05621.11 ORX59596.1 - 0.014 14.8 0.1 0.027 13.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ORX59596.1 - 0.045 13.8 0.0 3.5 7.8 0.0 3.2 2 1 1 3 3 3 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ORX59596.1 - 0.11 12.3 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TFIIB PF00382.19 ORX59597.1 - 0.00071 19.6 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ORX59597.1 - 0.092 12.3 0.9 0.18 11.4 0.9 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding DEAD PF00270.29 ORX59598.1 - 4.6e-47 160.0 0.0 8.2e-47 159.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX59598.1 - 2e-30 105.4 0.0 6.1e-30 103.8 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX59598.1 - 7.8e-06 26.0 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ORX59598.1 - 0.0048 15.7 0.0 0.016 14.0 0.0 1.7 2 0 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 PH PF00169.29 ORX59599.1 - 0.002 18.6 0.1 0.0053 17.2 0.1 1.7 1 0 0 1 1 1 1 PH domain Glyco_hydro_16 PF00722.21 ORX59600.1 - 2e-35 121.9 1.0 2.5e-35 121.6 1.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 HhH-GPD PF00730.25 ORX59601.1 - 2.9e-21 75.9 0.0 1.2e-20 73.9 0.0 2.1 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 ORX59601.1 - 5.5e-16 58.5 0.4 2.2e-15 56.6 0.1 2.2 1 1 1 2 2 2 1 NUDIX domain HHH PF00633.23 ORX59601.1 - 9.1e-06 25.3 0.0 1.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ORX59601.1 - 0.039 14.3 8.2 0.039 14.3 8.2 2.2 2 0 0 2 2 2 0 Iron-sulfur binding domain of endonuclease III Whib PF02467.16 ORX59601.1 - 0.48 11.1 3.5 0.78 10.4 1.2 2.6 2 1 1 3 3 3 0 Transcription factor WhiB zf-RING_6 PF14835.6 ORX59602.1 - 1.7e-10 40.6 2.6 3.5e-10 39.6 2.6 1.6 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 ORX59602.1 - 7.6e-10 38.5 6.2 7.6e-10 38.5 6.2 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX59602.1 - 1e-05 25.3 5.9 1e-05 25.3 5.9 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX59602.1 - 1.7e-05 25.0 6.6 1.7e-05 25.0 6.6 2.5 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX59602.1 - 3.2e-05 23.7 4.7 3.2e-05 23.7 4.7 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX59602.1 - 3.7e-05 23.6 7.6 3.7e-05 23.6 7.6 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-RanBP PF00641.18 ORX59602.1 - 6.4e-05 22.2 3.0 6.4e-05 22.2 3.0 2.2 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others BRCT PF00533.26 ORX59602.1 - 7.1e-05 23.1 0.1 0.00018 21.8 0.1 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain zf-RING_10 PF16685.5 ORX59602.1 - 0.00074 19.6 5.7 0.00074 19.6 5.7 2.2 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-rbx1 PF12678.7 ORX59602.1 - 0.0038 17.5 3.7 0.0038 17.5 3.7 2.3 3 0 0 3 3 3 1 RING-H2 zinc finger domain BRCT_2 PF16589.5 ORX59602.1 - 0.0049 17.2 0.1 0.012 16.0 0.1 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain zf-RING_UBOX PF13445.6 ORX59602.1 - 0.0069 16.4 5.3 0.0069 16.4 5.3 2.4 2 1 0 2 2 2 1 RING-type zinc-finger SWIRM-assoc_2 PF16496.5 ORX59602.1 - 0.1 11.5 0.0 0.22 10.3 0.0 1.5 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Prok-RING_4 PF14447.6 ORX59602.1 - 1.1 9.1 15.2 0.028 14.3 6.4 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 PHD_4 PF16866.5 ORX59602.1 - 5.9 7.1 10.0 1.2 9.3 0.2 3.2 3 0 0 3 3 3 0 PHD-finger PCMT PF01135.19 ORX59603.1 - 6.5e-77 258.0 0.0 7.7e-77 257.8 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ORX59603.1 - 8.5e-09 35.4 0.0 1.1e-08 35.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX59603.1 - 5e-07 30.3 0.0 9.4e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX59603.1 - 1.8e-05 24.7 0.0 2.5e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX59603.1 - 2.6e-05 24.8 0.0 4.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX59603.1 - 0.00018 20.9 0.0 0.00065 19.1 0.0 1.8 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 ORX59603.1 - 0.00091 19.2 0.0 0.0014 18.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX59603.1 - 0.0015 18.0 0.0 0.0029 17.1 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) GCD14 PF08704.10 ORX59603.1 - 0.0056 16.4 0.0 0.0081 15.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_12 PF08242.12 ORX59603.1 - 0.0056 17.4 0.0 0.0094 16.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX59603.1 - 0.0095 15.5 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 ORX59603.1 - 0.044 13.7 0.0 0.074 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 ORX59603.1 - 0.066 12.1 0.0 0.087 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) CMAS PF02353.20 ORX59603.1 - 0.073 12.3 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MetW PF07021.12 ORX59603.1 - 0.086 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW FtsJ PF01728.19 ORX59603.1 - 0.17 12.0 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase NAD_binding_10 PF13460.6 ORX59604.1 - 3.5e-19 69.4 0.0 4.6e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX59604.1 - 1.5e-15 57.4 0.0 1.8e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family TrkA_N PF02254.18 ORX59604.1 - 2.4e-05 24.6 0.0 4e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 ORX59604.1 - 0.003 17.7 0.0 0.0042 17.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 ORX59604.1 - 0.017 15.2 0.0 0.026 14.6 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ORX59604.1 - 0.094 13.3 0.0 0.31 11.6 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent p450 PF00067.22 ORX59605.1 - 2.8e-83 280.2 0.0 3.7e-83 279.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 ETF PF01012.21 ORX59606.1 - 4.5e-40 137.5 11.5 7.1e-40 136.8 11.5 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ORX59606.1 - 5.7e-36 122.4 0.8 5.7e-36 122.4 0.8 2.3 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Fungal_trans PF04082.18 ORX59608.1 - 9.7e-23 80.5 2.2 1.6e-22 79.8 2.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX59608.1 - 3.7e-07 30.2 14.5 7.2e-07 29.2 14.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain WRKY PF03106.15 ORX59609.1 - 6.8e-12 45.4 2.3 1.2e-11 44.7 2.3 1.3 1 0 0 1 1 1 1 WRKY DNA -binding domain FLYWCH PF04500.16 ORX59609.1 - 0.019 15.1 0.5 0.034 14.2 0.5 1.4 1 0 0 1 1 1 0 FLYWCH zinc finger domain Ribosomal_L13e PF01294.18 ORX59610.1 - 3.9e-46 157.2 0.6 6e-46 156.5 0.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e G_glu_transpept PF01019.21 ORX59611.1 - 9.8e-140 466.7 0.0 1.1e-139 466.5 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase NMT1_2 PF13379.6 ORX59611.1 - 0.0089 15.7 0.4 0.58 9.8 0.1 2.5 1 1 1 2 2 2 2 NMT1-like family BET PF17035.5 ORX59612.1 - 2.5e-06 27.6 0.2 2.5e-06 27.6 0.2 2.7 3 0 0 3 3 3 1 Bromodomain extra-terminal - transcription regulation RhoGAP PF00620.27 ORX59614.1 - 6.7e-39 133.1 0.6 6.7e-39 133.1 0.6 2.3 3 0 0 3 3 3 1 RhoGAP domain FCH PF00611.23 ORX59614.1 - 0.0016 18.7 0.4 0.017 15.4 0.0 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SUIM_assoc PF16619.5 ORX59614.1 - 0.013 15.6 6.2 0.013 15.6 6.2 4.2 2 1 1 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 PH PF00169.29 ORX59615.1 - 1.6e-16 60.7 0.1 2.8e-16 59.9 0.1 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ORX59615.1 - 7.1e-06 26.4 5.3 8.4e-05 23.0 0.3 3.1 2 1 1 3 3 3 1 Pleckstrin homology domain PH_9 PF15410.6 ORX59615.1 - 6.9e-05 23.2 0.1 0.0038 17.6 0.1 2.6 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ORX59615.1 - 7.8e-05 22.9 0.3 0.00026 21.2 0.3 1.9 1 1 0 1 1 1 1 Pleckstrin homology domain CtaG_Cox11 PF04442.14 ORX59616.1 - 3.3e-58 196.0 0.0 4.3e-58 195.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Methyltransf_25 PF13649.6 ORX59617.1 - 2.2e-06 28.3 0.0 3.9e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX59617.1 - 8.1e-05 23.2 0.0 0.00016 22.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX59617.1 - 0.0051 16.2 0.0 0.0078 15.6 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family LBR_tudor PF09465.10 ORX59618.1 - 0.1 12.4 0.1 0.8 9.6 0.0 2.4 2 1 1 3 3 3 0 Lamin-B receptor of TUDOR domain OrfB_Zn_ribbon PF07282.11 ORX59619.1 - 0.0012 18.8 3.1 0.0012 18.8 3.1 2.9 2 1 0 2 2 2 1 Putative transposase DNA-binding domain Kri1_C PF12936.7 ORX59620.1 - 2.7e-27 94.8 5.0 2.7e-27 94.8 5.0 4.7 5 0 0 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 ORX59620.1 - 4.2e-21 75.5 14.6 4.2e-21 75.5 14.6 6.1 5 2 1 6 6 6 1 KRI1-like family Fucose_iso_N2 PF07882.12 ORX59620.1 - 9.7 5.7 8.9 0.39 10.3 0.9 2.7 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain Med2 PF11214.8 ORX59621.1 - 0.00015 21.9 3.0 0.00015 21.9 3.0 2.0 2 1 1 3 3 3 1 Mediator complex subunit 2 Aminotran_1_2 PF00155.21 ORX59622.1 - 1.3e-33 116.7 0.0 1.7e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II FLILHELTA PF10306.9 ORX59623.1 - 5e-13 49.3 0.0 1.7e-12 47.5 0.0 1.8 2 0 0 2 2 2 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 ORX59623.1 - 0.00041 20.9 0.6 0.001 19.6 0.3 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1279) zf-C2H2 PF00096.26 ORX59624.1 - 2.2e-12 46.7 10.4 4.1e-06 26.9 3.7 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX59624.1 - 7.8e-11 41.9 16.6 4.7e-07 30.0 0.9 3.2 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX59624.1 - 1.7e-08 34.6 9.5 0.001 19.7 2.5 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ORX59624.1 - 0.00022 20.9 3.4 0.23 11.2 0.2 2.3 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-met PF12874.7 ORX59624.1 - 0.00055 20.2 1.3 0.00055 20.2 1.3 1.9 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 ORX59624.1 - 0.0017 18.6 2.5 0.02 15.2 0.2 2.0 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_aberr PF17017.5 ORX59624.1 - 0.011 15.9 0.2 0.015 15.5 0.1 1.3 1 1 0 1 1 1 0 Aberrant zinc-finger zf-C2H2_jaz PF12171.8 ORX59624.1 - 0.011 16.0 3.5 0.04 14.2 2.0 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX59624.1 - 0.035 14.1 2.2 0.035 14.1 2.2 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ORX59624.1 - 0.37 10.8 4.6 1.5 8.8 0.8 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Zds_C PF08632.10 ORX59626.1 - 2.8e-26 91.0 1.9 6e-26 90.0 1.9 1.5 1 0 0 1 1 1 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term CENP-B_dimeris PF09026.10 ORX59626.1 - 1 9.8 9.0 2 8.8 9.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 ORX59626.1 - 3.4 8.1 6.1 14 6.1 6.1 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal O-FucT PF10250.9 ORX59627.1 - 3.7e-12 46.6 0.0 4.2e-07 30.0 0.0 3.1 2 1 0 2 2 2 2 GDP-fucose protein O-fucosyltransferase Ferritin PF00210.24 ORX59628.1 - 8.4e-37 126.3 1.8 9.8e-37 126.0 1.8 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 ORX59628.1 - 3.5e-07 30.7 0.1 4.3e-07 30.4 0.1 1.2 1 0 0 1 1 1 1 Rubrerythrin APG17 PF04108.12 ORX59628.1 - 0.013 14.6 1.3 0.015 14.4 1.3 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Nitr_red_assoc PF09655.10 ORX59628.1 - 0.03 15.0 0.3 0.045 14.4 0.3 1.3 1 0 0 1 1 1 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) FCH PF00611.23 ORX59628.1 - 0.068 13.5 0.5 0.2 12.0 0.4 2.0 1 1 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain AAA PF00004.29 ORX59629.1 - 1.7e-89 297.1 0.0 1.7e-43 148.2 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX59629.1 - 7.8e-22 76.8 2.5 1.6e-11 43.8 0.4 2.5 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ORX59629.1 - 1e-14 54.6 0.0 1.8e-06 27.8 0.0 3.3 3 0 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX59629.1 - 4.3e-11 43.2 0.0 0.00054 20.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ORX59629.1 - 9.1e-11 42.4 0.4 0.0098 16.3 0.0 4.1 2 2 0 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 ORX59629.1 - 9.8e-10 38.6 0.1 0.0041 17.1 0.0 3.5 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ORX59629.1 - 2.3e-09 36.9 0.0 0.0034 16.6 0.0 3.1 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_22 PF13401.6 ORX59629.1 - 4.3e-09 36.7 0.4 0.01 16.1 0.0 4.1 2 2 2 4 4 4 2 AAA domain AAA_33 PF13671.6 ORX59629.1 - 1.5e-07 31.7 0.0 0.0025 18.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ORX59629.1 - 5.3e-06 26.3 0.0 0.066 12.9 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 ORX59629.1 - 1.1e-05 25.7 0.0 0.17 12.3 0.0 2.8 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 ORX59629.1 - 1.7e-05 24.3 0.6 0.093 12.1 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ORX59629.1 - 1.7e-05 24.9 0.0 0.064 13.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 ORX59629.1 - 2.2e-05 24.6 0.0 0.00011 22.3 0.0 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain Rad17 PF03215.15 ORX59629.1 - 6.7e-05 22.9 0.0 0.009 16.0 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_18 PF13238.6 ORX59629.1 - 0.00011 22.8 0.0 0.043 14.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ORX59629.1 - 0.00012 22.4 0.0 0.078 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ORX59629.1 - 0.00029 20.4 0.0 0.22 11.1 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region ATPase PF06745.13 ORX59629.1 - 0.00038 19.9 0.1 0.81 9.0 0.0 3.1 2 1 1 3 3 3 2 KaiC Sigma54_activ_2 PF14532.6 ORX59629.1 - 0.00055 20.1 0.0 0.93 9.6 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_25 PF13481.6 ORX59629.1 - 0.00095 18.8 2.1 4.8 6.7 0.0 3.9 3 1 0 4 4 4 1 AAA domain AAA_3 PF07726.11 ORX59629.1 - 0.0013 18.6 0.0 1.7 8.5 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ORX59629.1 - 0.0019 18.2 0.0 1.4 8.9 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ORX59629.1 - 0.002 17.9 0.0 0.72 9.5 0.0 3.4 3 1 0 3 3 2 1 Sigma-54 interaction domain Parvo_NS1 PF01057.17 ORX59629.1 - 0.0034 16.5 0.0 0.17 11.0 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_24 PF13479.6 ORX59629.1 - 0.0039 16.9 0.1 1.3 8.7 0.1 2.6 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 ORX59629.1 - 0.011 15.2 0.1 0.5 9.8 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Zeta_toxin PF06414.12 ORX59629.1 - 0.012 14.9 0.1 2.7 7.2 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin Vps4_C PF09336.10 ORX59629.1 - 0.014 15.3 0.0 5.4 7.1 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain DUF815 PF05673.13 ORX59629.1 - 0.016 14.4 0.0 0.7 9.0 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 ORX59629.1 - 0.044 14.3 0.0 5.1 7.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA_11 PF13086.6 ORX59629.1 - 0.052 13.3 0.0 3.4 7.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain IPT PF01745.16 ORX59629.1 - 0.11 11.9 0.7 3.1 7.1 0.0 2.6 3 0 0 3 3 3 0 Isopentenyl transferase NACHT PF05729.12 ORX59629.1 - 0.11 12.4 0.8 21 5.0 0.0 3.4 4 0 0 4 4 4 0 NACHT domain AAA_30 PF13604.6 ORX59629.1 - 0.16 11.7 0.1 2.4 7.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain XPG_I PF00867.18 ORX59630.1 - 1.2e-16 60.9 0.0 2.4e-16 59.8 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 ORX59630.1 - 7.8e-10 39.1 0.0 1.8e-09 38.0 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ORX59630.1 - 0.015 15.9 0.0 0.093 13.3 0.0 2.3 3 0 0 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold Spore_III_AB PF09548.10 ORX59630.1 - 0.033 14.3 0.7 0.055 13.6 0.7 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Baculo_PEP_C PF04513.12 ORX59630.1 - 0.37 10.8 2.8 1.7 8.7 2.3 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlgN PF05130.12 ORX59630.1 - 1.1 9.8 6.6 3.4 8.2 6.7 1.8 1 1 0 1 1 1 0 FlgN protein YlqD PF11068.8 ORX59630.1 - 4.3 7.7 6.9 15 5.9 1.9 2.4 1 1 1 2 2 2 0 YlqD protein Pkinase PF00069.25 ORX59631.1 - 1.9e-51 175.0 0.7 4.3e-51 173.8 0.7 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59631.1 - 3e-20 72.6 0.0 4.4e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX59631.1 - 0.0015 18.5 0.1 0.0042 17.0 0.1 1.7 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX59631.1 - 0.018 14.6 0.9 0.15 11.6 1.0 2.1 1 1 0 1 1 1 0 RIO1 family LPD24 PF18839.1 ORX59631.1 - 0.15 12.4 1.0 0.3 11.4 0.1 2.0 2 0 0 2 2 2 0 Large polyvalent protein associated domain 24 bZIP_2 PF07716.15 ORX59632.1 - 4.2e-12 45.9 9.6 6e-12 45.4 9.6 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX59632.1 - 0.0016 18.5 9.5 0.0034 17.4 9.5 1.6 1 0 0 1 1 1 1 bZIP transcription factor CREPT PF16566.5 ORX59632.1 - 0.027 14.6 0.8 0.045 13.9 0.8 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour LIM PF00412.22 ORX59633.1 - 8.5e-38 128.4 38.4 3.9e-13 49.4 6.6 3.2 3 0 0 3 3 3 3 LIM domain zf-dskA_traR PF01258.17 ORX59633.1 - 0.0071 16.3 0.3 0.0071 16.3 0.3 3.7 5 0 0 5 5 5 1 Prokaryotic dksA/traR C4-type zinc finger FUR PF01475.19 ORX59633.1 - 1.2 9.3 3.7 15 5.7 1.4 2.4 2 0 0 2 2 2 0 Ferric uptake regulator family CPBP PF02517.16 ORX59634.1 - 1.4e-19 70.2 9.9 1.4e-19 70.2 9.9 1.9 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Cyt-b5 PF00173.28 ORX59636.1 - 1.8e-23 82.5 0.0 2e-23 82.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Pmp3 PF01679.17 ORX59637.1 - 1.7e-23 82.6 7.8 1.9e-23 82.4 7.8 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator Aldolase_II PF00596.21 ORX59638.1 - 5.1e-47 160.2 0.0 6.8e-47 159.8 0.0 1.2 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain G-patch PF01585.23 ORX59638.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 G-patch domain Bromodomain PF00439.25 ORX59639.1 - 4e-43 145.4 2.6 9.9e-21 73.6 0.1 2.6 2 0 0 2 2 2 2 Bromodomain RTX PF02382.15 ORX59639.1 - 0.31 10.7 2.3 0.58 9.8 2.3 1.4 1 0 0 1 1 1 0 N-terminal domain in RTX protein Stk19 PF10494.9 ORX59640.1 - 3.1e-26 92.6 0.3 5.4e-26 91.8 0.3 1.3 1 1 0 1 1 1 1 Serine-threonine protein kinase 19 Arginase PF00491.21 ORX59641.1 - 7.3e-89 298.0 0.0 9.2e-89 297.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 ORX59641.1 - 0.0005 20.4 0.0 0.00075 19.8 0.0 1.3 1 0 0 1 1 1 1 UPF0489 domain Med27 PF11571.8 ORX59642.1 - 2.1e-18 66.4 1.7 2.4e-18 66.2 0.5 1.8 2 0 0 2 2 2 1 Mediator complex subunit 27 Snapin_Pallidin PF14712.6 ORX59642.1 - 0.011 16.2 0.1 0.025 15.0 0.1 1.7 1 0 0 1 1 1 0 Snapin/Pallidin UCR_hinge PF02320.16 ORX59643.1 - 5.6e-18 64.9 3.6 5.6e-18 64.9 3.6 1.8 1 1 2 3 3 3 1 Ubiquinol-cytochrome C reductase hinge protein zf-C2HE PF16278.5 ORX59643.1 - 0.042 14.3 3.8 0.11 12.9 3.8 1.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2052 PF09747.9 ORX59643.1 - 0.048 13.8 3.4 0.057 13.5 3.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) ROS_MUCR PF05443.11 ORX59643.1 - 0.049 13.7 0.1 0.068 13.2 0.1 1.2 1 0 0 1 1 1 0 ROS/MUCR transcriptional regulator protein FAM150 PF15129.6 ORX59643.1 - 0.16 12.1 1.5 10 6.3 1.4 2.4 1 1 0 1 1 1 0 FAM150 family Sporozoite_P67 PF05642.11 ORX59644.1 - 9.3 4.2 6.2 20 3.1 6.2 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Myb_DNA-binding PF00249.31 ORX59645.1 - 5.9e-13 48.8 0.0 1.9e-12 47.1 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain JAB PF01398.21 ORX59645.1 - 2.9e-12 46.6 0.1 8.4e-12 45.1 0.1 1.8 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ORX59645.1 - 2.6e-07 30.4 0.1 5.7e-07 29.3 0.1 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-bind_6 PF13921.6 ORX59645.1 - 0.0024 18.1 0.0 0.007 16.6 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain SR-25 PF10500.9 ORX59645.1 - 0.047 13.3 9.8 1.4 8.5 0.2 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GAGA_bind PF06217.12 ORX59645.1 - 2.6 8.2 10.1 1.8 8.7 1.3 2.5 2 0 0 2 2 2 0 GAGA binding protein-like family KxDL PF10241.9 ORX59646.1 - 0.002 18.3 2.8 0.0023 18.2 1.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein SlyX PF04102.12 ORX59646.1 - 0.015 15.9 6.8 2 9.1 1.8 3.4 3 0 0 3 3 3 0 SlyX eIF3_N PF09440.10 ORX59646.1 - 0.027 14.9 1.3 0.063 13.7 1.3 1.7 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain CHAD PF05235.14 ORX59646.1 - 0.058 13.4 2.8 0.094 12.7 2.8 1.3 1 0 0 1 1 1 0 CHAD domain UPF0449 PF15136.6 ORX59646.1 - 0.06 13.8 0.5 0.18 12.3 0.5 1.8 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 SCIMP PF15050.6 ORX59646.1 - 0.094 13.2 1.9 0.38 11.2 0.2 2.4 2 0 0 2 2 2 0 SCIMP protein MICSWaP PF17018.5 ORX59646.1 - 0.18 11.3 0.4 0.31 10.6 0.4 1.3 1 0 0 1 1 1 0 Spore wall protein THOC7 PF05615.13 ORX59646.1 - 0.28 11.5 7.0 0.92 9.8 7.0 1.9 1 1 0 1 1 1 0 Tho complex subunit 7 NPV_P10 PF05531.12 ORX59646.1 - 0.36 11.3 2.0 1.1 9.7 0.4 2.6 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ORX59646.1 - 0.39 10.8 6.8 0.06 13.4 1.3 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ORX59646.1 - 1.8 8.8 7.5 2.2 8.4 2.7 2.5 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 ORX59646.1 - 4.9 7.8 8.5 8.9 6.9 0.3 3.7 1 1 1 3 3 3 0 Syntaxin 6, N-terminal F-box-like PF12937.7 ORX59647.1 - 3.6e-10 39.6 1.6 1.5e-09 37.5 0.6 2.6 2 0 0 2 2 2 1 F-box-like LRR_4 PF12799.7 ORX59647.1 - 1e-05 25.7 1.5 0.088 13.3 0.8 4.2 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX59647.1 - 1.4e-05 24.8 1.0 1.4e-05 24.8 1.0 3.4 4 0 0 4 4 4 1 F-box domain LRR_6 PF13516.6 ORX59647.1 - 6.7e-05 22.6 6.2 0.057 13.5 0.2 4.2 5 0 0 5 5 5 2 Leucine Rich repeat LRR_1 PF00560.33 ORX59647.1 - 0.0083 16.5 4.0 2.5 9.0 0.3 4.7 4 0 0 4 4 4 1 Leucine Rich Repeat KxDL PF10241.9 ORX59648.1 - 1.4e-19 70.2 3.7 1.6e-19 70.0 3.7 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein Cupin_4 PF08007.12 ORX59648.1 - 0.0027 17.2 0.4 0.0029 17.1 0.4 1.1 1 0 0 1 1 1 1 Cupin superfamily protein AMH_N PF04709.12 ORX59648.1 - 0.038 12.9 0.0 0.041 12.8 0.0 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region Laminin_II PF06009.12 ORX59648.1 - 0.057 13.4 0.6 0.074 13.1 0.6 1.2 1 0 0 1 1 1 0 Laminin Domain II Cep57_CLD PF14073.6 ORX59648.1 - 0.063 13.3 2.3 0.073 13.1 2.3 1.1 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 DUF2756 PF10956.8 ORX59648.1 - 0.097 13.2 4.1 0.18 12.3 4.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2756) Not1 PF04054.15 ORX59649.1 - 3.2e-108 361.9 3.0 3.2e-108 361.9 3.0 1.7 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 ATP-synt_F PF01990.17 ORX59650.1 - 2.2e-32 111.2 0.2 2.6e-32 111.0 0.2 1.1 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DXP_synthase_N PF13292.6 ORX59650.1 - 0.0061 15.8 0.0 0.0063 15.8 0.0 1.2 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase Cactin_mid PF10312.9 ORX59652.1 - 5e-65 218.9 9.2 5e-65 218.9 9.2 2.4 3 0 0 3 3 3 1 Conserved mid region of cactin CactinC_cactus PF09732.9 ORX59652.1 - 6.4e-61 203.8 8.6 1.2e-60 202.9 8.6 1.5 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein SF3A2 PF16835.5 ORX59652.1 - 0.059 13.7 1.8 0.089 13.2 0.0 2.3 2 0 0 2 2 2 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) eIF-5a PF01287.20 ORX59652.1 - 0.086 12.9 1.2 8.8 6.5 0.0 2.5 2 0 0 2 2 2 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold AIM24 PF01987.17 ORX59653.1 - 7.6e-39 133.6 0.0 1e-38 133.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Cullin_binding PF03556.15 ORX59654.1 - 2.1e-30 105.6 1.0 3.5e-30 104.9 1.0 1.3 1 0 0 1 1 1 1 Cullin binding UBA_4 PF14555.6 ORX59654.1 - 3.6e-07 29.9 0.1 1.1e-06 28.4 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ORX59654.1 - 0.0014 18.3 0.2 0.0034 17.0 0.2 1.6 1 0 0 1 1 1 1 TAP C-terminal domain KIP1 PF07765.12 ORX59655.1 - 0.4 10.8 1.8 0.48 10.6 0.5 1.9 2 0 0 2 2 2 0 KIP1-like protein KIP1 PF07765.12 ORX59656.1 - 0.23 11.6 1.1 0.46 10.6 0.5 1.9 2 0 0 2 2 2 0 KIP1-like protein FAM24 PF15193.6 ORX59656.1 - 0.25 12.2 2.1 0.65 10.8 0.9 2.4 2 0 0 2 2 2 0 FAM24 family Bax1-I PF01027.20 ORX59657.1 - 2.2e-28 99.5 21.0 2.7e-28 99.2 21.0 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF2834 PF11196.8 ORX59657.1 - 0.94 9.9 9.4 8.2 6.9 1.9 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF2834) Phage_holin_5_1 PF06946.11 ORX59657.1 - 1.1 9.6 4.3 0.77 10.2 1.0 2.2 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 DUF1761 PF08570.10 ORX59657.1 - 4.1 7.7 15.9 0.2 11.9 1.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1761) PI3K_P85_iSH2 PF16454.5 ORX59658.1 - 0.29 10.7 15.7 0.69 9.5 15.7 1.6 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Jnk-SapK_ap_N PF09744.9 ORX59658.1 - 1.1 9.5 13.9 7.6 6.7 13.5 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 GBP_C PF02841.14 ORX59658.1 - 7.9 5.8 14.7 82 2.4 14.7 2.0 1 1 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Pkinase PF00069.25 ORX59659.1 - 5.6e-68 229.1 0.0 7e-68 228.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59659.1 - 2.4e-33 115.5 0.0 3.3e-33 115.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 ORX59659.1 - 0.00022 21.4 0.0 0.00046 20.3 0.0 1.5 1 0 0 1 1 1 1 ABC1 family Kdo PF06293.14 ORX59659.1 - 0.003 17.0 0.1 0.0057 16.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX59659.1 - 0.0089 16.0 0.1 0.027 14.4 0.1 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX59659.1 - 0.03 13.1 0.0 0.048 12.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 ORX59659.1 - 0.083 12.2 0.0 0.19 11.0 0.0 1.6 1 1 0 1 1 1 0 Kinase-like Ribosomal_L11 PF00298.19 ORX59660.1 - 5.2e-32 110.2 0.3 8.2e-32 109.5 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 ORX59660.1 - 5.1e-24 83.9 0.5 8.5e-24 83.2 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain EamA PF00892.20 ORX59661.1 - 1.4e-17 64.1 35.6 9e-09 35.6 16.5 3.1 3 0 0 3 3 3 3 EamA-like transporter family SLC35F PF06027.12 ORX59661.1 - 7.7e-09 35.5 9.9 1e-08 35.1 8.7 1.8 2 1 0 2 2 2 1 Solute carrier family 35 PUNUT PF16913.5 ORX59661.1 - 1.1e-05 24.9 3.0 0.00019 20.7 0.6 2.2 2 0 0 2 2 2 2 Purine nucleobase transmembrane transport UAA PF08449.11 ORX59661.1 - 0.00086 18.6 14.0 0.0013 18.0 11.2 2.3 2 1 0 2 2 2 1 UAA transporter family VHS PF00790.19 ORX59662.1 - 2.3e-42 144.2 0.7 2.5e-41 140.9 0.0 2.6 3 0 0 3 3 3 1 VHS domain Alpha_adaptinC2 PF02883.20 ORX59662.1 - 7.5e-21 74.5 0.3 1.8e-20 73.3 0.3 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 ORX59662.1 - 3.6e-19 68.8 3.7 3.6e-19 68.8 3.7 3.0 3 0 0 3 3 3 1 GAT domain GGA_N-GAT PF18308.1 ORX59662.1 - 9.7e-06 25.1 0.1 5.5e-05 22.7 0.0 2.3 2 0 0 2 2 2 1 GGA N-GAT domain DUF2407_C PF13373.6 ORX59663.1 - 3.9e-13 49.8 0.7 5.7e-13 49.2 0.7 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 ORX59663.1 - 5.5e-07 30.1 0.1 7.1e-06 26.5 0.0 2.1 1 1 1 2 2 2 1 DUF2407 ubiquitin-like domain ubiquitin PF00240.23 ORX59663.1 - 4.9e-06 26.2 0.0 2.1e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 ORX59663.1 - 0.00068 19.7 0.0 0.0011 19.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD PF11976.8 ORX59663.1 - 0.047 13.5 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like CPSase_L_D2 PF02786.17 ORX59664.1 - 5.3e-77 258.1 0.0 1.2e-76 257.0 0.0 1.5 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ORX59664.1 - 9.5e-43 145.2 0.0 3.5e-42 143.4 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX59664.1 - 5.6e-31 106.8 0.0 1.4e-30 105.6 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ORX59664.1 - 4.2e-18 65.0 0.6 7.9e-18 64.1 0.6 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX59664.1 - 2.2e-09 37.2 0.0 4.5e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus Biotin_lipoyl_2 PF13533.6 ORX59664.1 - 2.2e-09 37.0 0.9 0.0009 19.0 0.0 2.9 1 1 1 2 2 2 2 Biotin-lipoyl like PCC_BT PF18140.1 ORX59664.1 - 3.5e-09 37.1 0.0 9.1e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain ATP-grasp PF02222.22 ORX59664.1 - 1.2e-07 31.4 0.0 2.8e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 ORX59664.1 - 0.0018 17.6 0.2 0.2 10.8 0.0 2.3 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 ORX59664.1 - 0.026 15.2 0.1 2.6 8.8 0.0 2.6 2 0 0 2 2 2 0 HlyD family secretion protein ATP-grasp_3 PF02655.14 ORX59664.1 - 0.037 14.1 0.0 0.079 13.0 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_ST PF14397.6 ORX59664.1 - 0.055 12.7 0.0 0.46 9.7 0.0 2.0 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp MipZ PF09140.11 ORX59664.1 - 0.13 11.5 0.1 0.27 10.5 0.1 1.4 1 0 0 1 1 1 0 ATPase MipZ RnfC_N PF13375.6 ORX59664.1 - 0.26 11.3 1.1 1.4 8.9 0.4 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Myb_DNA-bind_6 PF13921.6 ORX59665.1 - 1.1e-10 41.6 3.0 5.2e-05 23.4 0.0 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX59665.1 - 3.3e-10 40.0 3.8 3.9e-05 23.8 1.4 2.1 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 ORX59665.1 - 0.0029 17.6 0.0 0.076 13.0 0.1 2.0 2 0 0 2 2 2 1 SLIDE Myb_DNA-bind_2 PF08914.11 ORX59665.1 - 0.051 13.8 0.5 10 6.4 0.4 2.5 2 1 0 2 2 2 0 Rap1 Myb domain Myb_DNA-bind_4 PF13837.6 ORX59665.1 - 0.069 13.5 4.9 0.18 12.2 1.5 2.4 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain fn2 PF00040.19 ORX59665.1 - 0.25 11.7 3.4 0.85 9.9 0.2 2.6 3 0 0 3 3 3 0 Fibronectin type II domain Ephrin_rec_like PF07699.13 ORX59666.1 - 8.4e-05 22.3 12.1 0.0018 18.0 11.0 2.7 1 1 1 2 2 2 2 Putative ephrin-receptor like Pkinase_Tyr PF07714.17 ORX59666.1 - 0.00024 20.5 0.1 0.0004 19.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase NCD3G PF07562.14 ORX59666.1 - 0.00099 19.0 1.0 0.00099 19.0 1.0 2.7 3 0 0 3 3 3 1 Nine Cysteines Domain of family 3 GPCR DUF4448 PF14610.6 ORX59666.1 - 0.026 14.3 0.1 0.11 12.2 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) Pkinase PF00069.25 ORX59666.1 - 0.039 13.3 0.1 0.065 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein kinase domain TNFR_c6 PF00020.18 ORX59666.1 - 0.12 12.8 10.4 0.41 11.1 1.4 3.4 1 1 2 3 3 3 0 TNFR/NGFR cysteine-rich region HATPase_c PF02518.26 ORX59667.1 - 2.6e-29 102.0 0.0 5e-29 101.1 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX59667.1 - 5.2e-24 84.6 0.5 1.3e-23 83.3 0.1 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 ORX59667.1 - 1.6e-18 66.5 0.7 5.8e-18 64.7 0.0 2.3 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain Arrestin_C PF02752.22 ORX59671.1 - 7.5e-10 39.4 0.0 1.7e-08 35.0 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ORX59671.1 - 1.4e-06 28.4 0.0 0.00048 20.2 0.1 3.2 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_N PF00339.29 ORX59672.1 - 9.4e-07 29.0 0.0 0.0034 17.5 0.0 2.5 2 1 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX59672.1 - 0.00014 22.3 0.0 0.074 13.5 0.0 2.4 2 1 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Rgp1 PF08737.10 ORX59672.1 - 0.02 14.1 0.0 0.033 13.4 0.0 1.2 1 0 0 1 1 1 0 Rgp1 Cwf_Cwc_15 PF04889.12 ORX59673.1 - 2.8e-77 259.8 24.9 3.1e-77 259.6 24.9 1.0 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ORX59673.1 - 0.49 8.6 21.0 0.55 8.5 21.0 1.2 1 0 0 1 1 1 0 CDC45-like protein GEMIN8 PF15348.6 ORX59673.1 - 0.58 10.4 15.3 0.69 10.2 15.3 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 PA26 PF04636.13 ORX59673.1 - 0.89 8.4 7.2 1 8.2 7.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Nop14 PF04147.12 ORX59673.1 - 1.1 7.4 26.1 1.3 7.2 26.1 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 ORX59673.1 - 4.2 6.0 11.7 5.1 5.8 11.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SURF2 PF05477.11 ORX59673.1 - 6.3 6.4 16.2 8.5 6.0 16.2 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Hid1 PF12722.7 ORX59673.1 - 9.3 4.2 11.7 12 3.9 11.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Histone PF00125.24 ORX59674.1 - 1e-05 25.9 1.3 2.7e-05 24.5 1.3 1.7 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ORX59674.1 - 0.021 15.1 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ATAD4 PF15321.6 ORX59674.1 - 0.9 10.9 3.2 0.82 11.1 1.5 1.9 2 1 0 2 2 2 0 ATPase family AAA domain containing 4 CBFD_NFYB_HMF PF00808.23 ORX59675.1 - 2.9e-07 30.7 0.1 3.7e-07 30.3 0.1 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 ORX59675.1 - 8e-07 29.5 0.0 1e-06 29.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 IRK PF01007.20 ORX59675.1 - 0.087 12.6 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain p450 PF00067.22 ORX59678.1 - 2.5e-57 194.7 0.0 3.3e-57 194.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 AD PF09793.9 ORX59679.1 - 2.9e-28 97.8 0.0 4.3e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Anticodon-binding domain LSM PF01423.22 ORX59679.1 - 0.011 15.5 0.0 0.017 14.8 0.0 1.4 1 0 0 1 1 1 0 LSM domain Gemin6 PF06372.12 ORX59679.1 - 0.014 14.9 0.1 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 Gemin6 protein Rit1_C PF17184.4 ORX59679.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Rit1 N-terminal domain SM-ATX PF14438.6 ORX59679.1 - 0.13 12.4 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 Ataxin 2 SM domain OrfB_Zn_ribbon PF07282.11 ORX59680.1 - 0.01 15.8 0.1 0.02 14.8 0.1 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain SOG2 PF10428.9 ORX59680.1 - 4.5 6.4 12.1 6.3 5.9 12.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PP2C PF00481.21 ORX59682.1 - 3.1e-35 122.0 0.0 1.1e-30 107.2 0.0 2.4 2 1 0 2 2 2 2 Protein phosphatase 2C Glyco_hydro81C PF17652.1 ORX59683.1 - 1.6e-104 349.9 0.2 2.3e-104 349.4 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 ORX59683.1 - 2.6e-51 174.7 1.3 3.6e-51 174.2 1.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain WD40 PF00400.32 ORX59688.1 - 4.2e-38 128.7 15.2 4.6e-07 30.4 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX59688.1 - 7e-16 58.3 0.1 0.00055 20.2 0.1 5.0 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX59688.1 - 0.00063 19.2 0.0 0.65 9.3 0.0 2.9 3 1 1 4 4 4 2 WD40-like domain eIF2A PF08662.11 ORX59688.1 - 0.0012 18.7 0.0 1.4 8.7 0.0 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ORX59688.1 - 0.012 14.2 0.1 0.028 13.0 0.1 1.5 2 0 0 2 2 2 0 Cytochrome D1 heme domain TCO89 PF10452.9 ORX59689.1 - 7.4e-08 31.8 0.1 1e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 TORC1 subunit TCO89 Cep57_CLD_2 PF14197.6 ORX59690.1 - 0.0095 16.0 0.3 0.017 15.2 0.3 1.4 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 ACBP PF00887.19 ORX59691.1 - 7.1e-17 61.4 0.0 9e-17 61.1 0.0 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein ARID PF01388.21 ORX59691.1 - 0.065 13.9 0.0 0.076 13.7 0.0 1.2 1 0 0 1 1 1 0 ARID/BRIGHT DNA binding domain ArfGap PF01412.18 ORX59692.1 - 2e-42 143.9 0.7 3.1e-42 143.4 0.7 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BCDHK_Adom3 PF10436.9 ORX59693.1 - 1.8e-43 148.2 0.0 2.9e-43 147.5 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX59693.1 - 9.4e-11 42.2 0.1 5.2e-10 39.8 0.1 2.1 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX59693.1 - 6.7e-06 26.0 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ORX59693.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Ccdc124 PF06244.12 ORX59694.1 - 1.4e-26 93.6 30.6 3.7e-25 89.0 30.6 2.2 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 ABC_membrane PF00664.23 ORX59695.1 - 5.1e-87 292.0 30.2 1.7e-45 155.8 7.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX59695.1 - 3.8e-51 173.2 0.6 6.4e-26 91.5 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ORX59695.1 - 3.9e-11 42.8 0.0 5.9e-05 22.6 0.0 3.5 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX59695.1 - 0.0001 22.2 0.5 1.2 8.8 0.0 3.9 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ORX59695.1 - 0.00034 21.1 0.4 1.6 9.1 0.1 2.8 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 ORX59695.1 - 0.00054 19.6 2.3 0.012 15.4 0.2 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 ORX59695.1 - 0.00065 19.9 5.3 0.22 11.6 1.2 2.6 2 0 0 2 2 2 2 Helicase HerA, central domain T2SSE PF00437.20 ORX59695.1 - 0.0032 16.6 0.3 2.3 7.2 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ORX59695.1 - 0.0039 17.1 0.4 0.04 13.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ORX59695.1 - 0.0068 16.5 3.4 0.085 12.9 0.8 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ORX59695.1 - 0.01 16.3 3.0 0.53 10.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain AAA_25 PF13481.6 ORX59695.1 - 0.018 14.6 0.2 0.51 9.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ORX59695.1 - 0.025 14.1 0.9 2.4 7.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_15 PF13175.6 ORX59695.1 - 0.03 14.0 0.4 0.45 10.2 0.3 2.3 2 0 0 2 2 2 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 ORX59695.1 - 0.03 13.2 0.3 0.86 8.5 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Dynamin_N PF00350.23 ORX59695.1 - 0.031 14.3 0.1 0.031 14.3 0.1 1.8 2 0 0 2 2 1 0 Dynamin family FtsK_SpoIIIE PF01580.18 ORX59695.1 - 0.038 13.4 1.1 2.3 7.5 0.1 2.4 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 ORX59695.1 - 0.04 14.2 7.5 1.9 8.8 0.5 3.3 3 1 0 3 3 2 0 AAA domain DEAD PF00270.29 ORX59695.1 - 0.076 12.8 3.1 4.7 6.9 2.4 3.1 2 1 0 2 2 2 0 DEAD/DEAH box helicase IstB_IS21 PF01695.17 ORX59695.1 - 0.08 12.7 0.6 15 5.2 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 ORX59695.1 - 0.19 11.4 7.4 4 7.1 0.1 3.9 4 1 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 ORX59695.1 - 0.88 9.3 2.8 5.8 6.6 0.5 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein IlvN PF07991.12 ORX59696.1 - 2.6e-45 154.0 0.0 4.2e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ORX59696.1 - 6.9e-43 146.4 0.0 1.3e-42 145.5 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 ORX59696.1 - 0.0058 16.8 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ORX59696.1 - 0.018 15.6 0.0 0.042 14.4 0.0 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 ORX59696.1 - 0.059 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain SHMT PF00464.19 ORX59697.1 - 5.8e-174 578.4 0.0 7e-174 578.1 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 ORX59697.1 - 2e-05 24.1 0.0 0.0001 21.7 0.0 2.0 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 ORX59697.1 - 0.0001 21.6 0.0 0.00025 20.4 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II DUF4142 PF13628.6 ORX59697.1 - 0.045 14.0 0.1 0.1 12.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) DegT_DnrJ_EryC1 PF01041.17 ORX59697.1 - 0.056 12.7 0.0 0.13 11.6 0.0 1.6 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Sulfate_transp PF00916.20 ORX59698.1 - 1.7e-90 303.5 17.7 2.4e-90 303.0 17.7 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX59698.1 - 1.2e-23 83.0 0.0 2e-23 82.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX59698.1 - 0.00031 21.1 14.5 0.00047 20.5 4.5 3.2 2 1 0 2 2 2 2 Molybdate transporter of MFS superfamily DUF1656 PF07869.12 ORX59698.1 - 0.053 13.5 0.4 0.053 13.5 0.4 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1656) WD40 PF00400.32 ORX59699.1 - 6.9e-34 115.3 29.7 3.4e-06 27.7 1.3 7.8 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX59699.1 - 2.7e-14 53.2 1.0 0.0092 16.3 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ORX59699.1 - 1.4e-10 40.9 3.6 3.1e-10 39.8 3.6 1.6 1 0 0 1 1 1 1 F-box-like Nup160 PF11715.8 ORX59699.1 - 6.7e-09 34.9 6.5 0.0011 17.8 0.2 4.4 2 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX59699.1 - 1.5e-07 31.1 0.1 0.18 11.1 0.1 3.4 2 1 0 3 3 3 3 WD40-like domain F-box PF00646.33 ORX59699.1 - 5.4e-05 23.0 4.5 0.00012 21.8 4.5 1.7 1 0 0 1 1 1 1 F-box domain DUF5046 PF16465.5 ORX59699.1 - 0.00098 18.7 0.4 2.9 7.3 0.0 3.3 2 1 2 4 4 4 2 Domain of unknown function (DUF5046) Hira PF07569.11 ORX59699.1 - 0.32 10.7 1.4 25 4.5 0.0 3.4 1 1 2 4 4 4 0 TUP1-like enhancer of split PQQ_3 PF13570.6 ORX59699.1 - 7 7.3 8.2 50 4.6 0.0 5.1 5 1 2 7 7 7 0 PQQ-like domain zf-C2H2 PF00096.26 ORX59700.1 - 1.6e-09 37.7 29.0 0.001 19.4 1.8 4.1 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX59700.1 - 1.4e-08 34.8 29.1 0.00031 21.0 5.3 4.7 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX59700.1 - 2.5e-06 27.8 24.4 0.023 15.5 0.5 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX59700.1 - 0.00023 21.4 7.5 0.0088 16.3 4.2 2.2 1 1 1 2 2 2 2 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX59700.1 - 0.0022 18.6 10.5 1.1 9.9 0.0 4.0 1 1 3 4 4 4 1 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX59700.1 - 0.0027 17.7 2.9 0.031 14.3 0.2 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger zf-TAZ PF02135.16 ORX59700.1 - 0.0038 17.7 7.0 0.095 13.2 1.0 2.6 1 1 1 2 2 2 2 TAZ zinc finger DUF448 PF04296.13 ORX59700.1 - 0.039 13.8 0.4 1.7 8.5 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF448) Toxin_8 PF07365.12 ORX59700.1 - 0.15 12.2 1.9 4.9 7.4 0.2 2.4 2 0 0 2 2 2 0 Alpha conotoxin precursor zf_ZIC PF18366.1 ORX59700.1 - 4 7.6 9.6 16 5.7 0.0 3.5 4 0 0 4 4 4 0 Zic proteins zinc finger domain zf-C2H2_aberr PF17017.5 ORX59700.1 - 5.8 7.0 8.0 4.1 7.5 2.0 2.5 1 1 1 3 3 3 0 Aberrant zinc-finger MAPEG PF01124.18 ORX59701.1 - 3.3e-27 95.0 0.0 3.7e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 MAPEG family DUF2859 PF11072.8 ORX59701.1 - 0.11 12.3 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2859) Phosphoesterase PF04185.14 ORX59702.1 - 1.8e-30 106.3 2.1 1.8e-30 106.3 2.1 2.1 2 1 0 2 2 2 1 Phosphoesterase family Glyco_transf_49 PF13896.6 ORX59703.1 - 3.2e-43 148.3 0.2 1e-33 117.1 0.1 2.4 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan IlvN PF07991.12 ORX59704.1 - 6.5e-45 152.7 0.0 1.1e-44 152.0 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 ORX59704.1 - 7.6e-43 146.2 0.0 1.4e-42 145.4 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 ORX59704.1 - 0.0037 17.5 0.0 0.0076 16.4 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ORX59704.1 - 0.011 16.3 0.0 0.025 15.1 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 ORX59704.1 - 0.07 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Ysc84 PF04366.12 ORX59705.1 - 8e-42 142.0 0.2 1.5e-41 141.1 0.2 1.5 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_9 PF14604.6 ORX59706.1 - 5.9e-11 42.1 0.0 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX59706.1 - 6.3e-11 41.7 0.1 1.1e-10 40.9 0.1 1.4 1 0 0 1 1 1 1 SH3 domain FCH PF00611.23 ORX59706.1 - 3.7e-09 36.7 2.0 3.8e-09 36.7 0.1 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 ORX59706.1 - 1.3e-06 27.9 0.0 2.4e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain BAR_3 PF16746.5 ORX59706.1 - 0.085 12.6 5.7 0.14 11.9 5.7 1.3 1 0 0 1 1 1 0 BAR domain of APPL family DUF1759 PF03564.15 ORX59706.1 - 0.26 11.2 3.2 1.6 8.7 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) RRM_1 PF00076.22 ORX59707.1 - 6.1e-14 51.6 0.0 6.5e-14 51.5 0.0 1.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX59707.1 - 0.0057 16.2 0.0 0.0069 16.0 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ORX59707.1 - 0.16 11.9 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 RL domain AAA_18 PF13238.6 ORX59708.1 - 4.1e-25 88.8 0.2 7.2e-25 88.0 0.0 1.4 2 0 0 2 2 1 1 AAA domain AAA_17 PF13207.6 ORX59708.1 - 5.4e-07 30.1 0.2 1.7e-06 28.5 0.1 1.9 1 1 1 2 2 2 1 AAA domain ADK PF00406.22 ORX59708.1 - 1.7e-06 28.2 0.1 0.00013 22.2 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase AAA_33 PF13671.6 ORX59708.1 - 5.2e-05 23.4 0.0 0.00015 21.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ORX59708.1 - 0.00015 22.2 1.4 0.0005 20.5 0.3 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ORX59708.1 - 0.00052 20.3 1.3 0.00082 19.6 1.3 1.7 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX59708.1 - 0.0036 17.6 0.3 0.0075 16.6 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX59708.1 - 0.0043 17.5 0.0 0.0095 16.3 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ORX59708.1 - 0.0047 16.3 0.2 0.011 15.1 0.0 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family KTI12 PF08433.10 ORX59708.1 - 0.0059 16.1 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_19 PF13245.6 ORX59708.1 - 0.0092 16.3 0.9 0.0092 16.3 0.9 1.8 2 1 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX59708.1 - 0.011 15.7 0.4 0.025 14.5 0.4 1.6 1 0 0 1 1 1 0 NTPase AAA_11 PF13086.6 ORX59708.1 - 0.014 15.1 0.1 0.81 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX59708.1 - 0.015 14.6 0.0 0.037 13.3 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin RuvB_N PF05496.12 ORX59708.1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain T2SSE PF00437.20 ORX59708.1 - 0.019 14.0 0.1 0.032 13.3 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein ATPase PF06745.13 ORX59708.1 - 0.032 13.6 0.3 0.074 12.4 0.0 1.7 2 0 0 2 2 2 0 KaiC TniB PF05621.11 ORX59708.1 - 0.032 13.6 0.0 0.062 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_5 PF07728.14 ORX59708.1 - 0.032 14.2 0.1 0.084 12.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ORX59708.1 - 0.033 13.9 2.0 0.16 11.7 0.5 2.4 2 2 0 2 2 2 0 AAA domain SKI PF01202.22 ORX59708.1 - 0.035 14.2 0.3 0.071 13.2 0.3 1.7 1 1 0 1 1 1 0 Shikimate kinase AAA_30 PF13604.6 ORX59708.1 - 0.05 13.3 0.0 0.089 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mur_ligase_M PF08245.12 ORX59708.1 - 0.099 12.6 2.3 0.12 12.4 2.3 1.5 1 1 0 1 1 1 0 Mur ligase middle domain Sulfotransfer_1 PF00685.27 ORX59708.1 - 0.1 12.1 2.5 1.5 8.2 2.5 2.0 1 1 0 1 1 1 0 Sulfotransferase domain RNA_helicase PF00910.22 ORX59708.1 - 0.12 12.8 0.3 0.31 11.4 0.0 1.9 2 1 1 3 3 3 0 RNA helicase Hydin_ADK PF17213.3 ORX59708.1 - 0.16 12.3 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain MFS_1 PF07690.16 ORX59709.1 - 3.1e-32 111.9 28.1 3.1e-32 111.9 28.1 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2909 PF11137.8 ORX59709.1 - 0.018 15.0 0.8 0.68 9.9 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2909) MNSV_P7B PF06692.11 ORX59709.1 - 0.053 13.5 0.1 3.9 7.6 0.1 2.9 2 0 0 2 2 2 0 Melon necrotic spot virus P7B protein Pkinase PF00069.25 ORX59710.1 - 2.7e-55 187.6 0.0 3.6e-55 187.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX59710.1 - 5.4e-31 107.8 0.0 7.1e-31 107.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX59710.1 - 5.5e-07 29.2 0.0 1.2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 ORX59710.1 - 2.4e-05 24.1 0.0 0.025 14.2 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ORX59710.1 - 0.016 14.6 0.0 0.034 13.5 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PPTA PF01239.22 ORX59711.1 - 6.1e-11 41.7 9.6 3.1e-07 29.9 1.7 3.7 3 0 0 3 3 3 3 Protein prenyltransferase alpha subunit repeat Slx4 PF09494.10 ORX59711.1 - 0.032 14.2 0.5 0.16 12.0 0.1 2.3 2 0 0 2 2 2 0 Slx4 endonuclease MFS_1 PF07690.16 ORX59712.1 - 1.9e-28 99.4 42.8 1.9e-28 99.4 42.8 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily SesA PF17107.5 ORX59714.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Ribosomal_L18A PF01775.17 ORX59715.1 - 2.7e-53 179.2 0.3 3.8e-53 178.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Lipoprotein_9 PF03180.14 ORX59715.1 - 0.13 11.3 0.0 0.2 10.7 0.0 1.2 1 0 0 1 1 1 0 NLPA lipoprotein AAA PF00004.29 ORX59716.1 - 7.7e-96 317.6 0.0 7e-49 165.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX59716.1 - 2.1e-24 85.1 2.1 8.2e-12 44.7 0.2 2.9 3 0 0 3 3 2 2 AAA+ lid domain RuvB_N PF05496.12 ORX59716.1 - 4.3e-16 59.1 0.0 9.7e-09 35.2 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ORX59716.1 - 8.7e-13 49.0 7.4 4.5e-05 23.9 0.1 5.4 3 2 1 4 4 4 2 AAA ATPase domain AAA_5 PF07728.14 ORX59716.1 - 1.2e-11 44.8 1.7 0.00029 20.9 0.0 5.2 5 2 0 5 5 4 2 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX59716.1 - 1.2e-10 41.8 0.0 0.00015 21.9 0.0 2.9 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX59716.1 - 2.3e-10 40.9 1.9 0.024 14.9 0.0 5.2 3 2 3 6 6 5 2 AAA domain AAA_33 PF13671.6 ORX59716.1 - 1.2e-09 38.5 0.0 0.0014 18.8 0.0 2.9 2 1 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ORX59716.1 - 7.9e-09 35.9 0.0 0.0084 16.5 0.0 3.0 2 1 0 2 2 2 2 RNA helicase TIP49 PF06068.13 ORX59716.1 - 9e-08 31.7 0.0 0.0049 16.1 0.0 2.8 3 1 0 3 3 3 2 TIP49 P-loop domain AAA_14 PF13173.6 ORX59716.1 - 2.4e-07 30.9 0.0 0.018 15.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 ORX59716.1 - 3.1e-07 30.3 0.3 0.028 14.1 0.0 3.2 3 1 0 3 3 3 2 IstB-like ATP binding protein Zeta_toxin PF06414.12 ORX59716.1 - 4.6e-07 29.3 0.1 0.05 12.9 0.0 3.0 3 0 0 3 3 3 2 Zeta toxin NACHT PF05729.12 ORX59716.1 - 1.2e-06 28.6 0.1 0.046 13.6 0.0 3.9 4 0 0 4 4 4 2 NACHT domain ABC_tran PF00005.27 ORX59716.1 - 3.5e-06 27.6 0.0 0.073 13.6 0.0 3.1 2 0 0 2 2 2 2 ABC transporter Mg_chelatase PF01078.21 ORX59716.1 - 4e-06 26.4 0.3 0.058 12.8 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ORX59716.1 - 7.2e-06 26.6 0.0 0.25 11.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 ORX59716.1 - 7.5e-06 26.0 0.0 0.12 12.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 ORX59716.1 - 8.4e-06 26.1 0.0 0.09 13.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ORX59716.1 - 9.9e-06 25.2 0.0 0.23 11.0 0.0 3.3 3 1 0 3 3 3 2 P-loop containing dynein motor region AAA_25 PF13481.6 ORX59716.1 - 1.1e-05 25.2 3.3 1.7 8.1 0.0 4.6 5 0 0 5 5 5 2 AAA domain Sigma54_activat PF00158.26 ORX59716.1 - 3.7e-05 23.5 0.0 0.21 11.3 0.0 3.7 4 0 0 4 4 4 1 Sigma-54 interaction domain DUF815 PF05673.13 ORX59716.1 - 4.3e-05 22.8 0.0 0.016 14.4 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_11 PF13086.6 ORX59716.1 - 5.9e-05 23.0 0.1 0.25 11.1 0.0 2.9 3 0 0 3 3 3 2 AAA domain ATPase PF06745.13 ORX59716.1 - 8.6e-05 22.0 0.1 0.92 8.8 0.0 3.4 3 0 0 3 3 3 1 KaiC Rad17 PF03215.15 ORX59716.1 - 0.00012 22.0 0.0 0.53 10.2 0.0 2.4 2 0 0 2 2 2 2 Rad17 P-loop domain AAA_3 PF07726.11 ORX59716.1 - 0.00021 21.2 0.0 0.63 9.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ORX59716.1 - 0.00024 20.9 0.0 0.8 9.4 0.0 2.9 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 ORX59716.1 - 0.00028 21.3 0.0 0.89 10.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain Vps4_C PF09336.10 ORX59716.1 - 0.00042 20.3 2.3 0.26 11.3 0.1 4.0 3 1 0 3 3 3 1 Vps4 C terminal oligomerisation domain NB-ARC PF00931.22 ORX59716.1 - 0.00053 19.3 0.0 0.78 8.9 0.0 2.7 2 0 0 2 2 2 2 NB-ARC domain Cytidylate_kin2 PF13189.6 ORX59716.1 - 0.00056 20.1 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family ATPase_2 PF01637.18 ORX59716.1 - 0.00061 19.8 0.1 2.4 8.0 0.0 3.6 3 2 1 4 4 3 1 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ORX59716.1 - 0.0018 18.1 0.0 0.38 10.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 ORX59716.1 - 0.002 17.3 0.1 1.4 7.9 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 ORX59716.1 - 0.0032 17.4 0.0 3.1 7.7 0.0 2.9 2 1 0 2 2 2 1 NTPase Sigma54_activ_2 PF14532.6 ORX59716.1 - 0.004 17.3 0.0 1.2 9.2 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 ORX59716.1 - 0.0047 17.3 0.8 1.3 9.4 0.1 3.0 2 1 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 ORX59716.1 - 0.0065 16.3 0.0 5 6.9 0.0 2.6 2 1 0 2 2 2 0 Bacterial dnaA protein PhoH PF02562.16 ORX59716.1 - 0.01 15.3 0.1 2.4 7.6 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AFG1_ATPase PF03969.16 ORX59716.1 - 0.013 14.4 0.0 2.7 6.8 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase SKI PF01202.22 ORX59716.1 - 0.014 15.5 0.0 4.8 7.3 0.0 2.8 2 0 0 2 2 2 0 Shikimate kinase CPT PF07931.12 ORX59716.1 - 0.017 14.9 0.0 0.72 9.7 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein ATP-synt_ab PF00006.25 ORX59716.1 - 0.022 14.4 0.0 5.6 6.5 0.0 2.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.9 ORX59716.1 - 0.029 14.1 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Cytidylate_kin PF02224.18 ORX59716.1 - 0.079 12.7 0.0 9.8 5.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase Sun2_CC2 PF18580.1 ORX59716.1 - 0.11 12.8 0.0 2.9 8.2 0.0 3.0 2 0 0 2 2 2 0 SUN2 coiled coil domain 2 Hydin_ADK PF17213.3 ORX59716.1 - 0.18 12.0 1.0 2.7 8.2 0.0 2.9 3 0 0 3 3 2 0 Hydin Adenylate kinase-like domain Rep_fac_C PF08542.11 ORX59717.1 - 1.2e-24 86.6 0.0 6.7e-24 84.1 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 ORX59717.1 - 3.1e-12 47.0 0.0 4.8e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 ORX59717.1 - 4.4e-12 46.1 0.0 1.2e-10 41.5 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 ORX59717.1 - 2.3e-06 28.1 0.0 0.0002 21.8 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ORX59717.1 - 5.6e-06 26.4 0.0 1.1e-05 25.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX59717.1 - 0.00015 22.0 0.2 0.32 11.3 0.0 2.7 1 1 1 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 ORX59717.1 - 0.00053 19.8 0.0 0.00087 19.1 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_assoc_2 PF16193.5 ORX59717.1 - 0.0013 19.1 0.0 0.012 15.9 0.0 2.4 2 0 0 2 2 2 1 AAA C-terminal domain RuvB_N PF05496.12 ORX59717.1 - 0.0017 18.1 0.0 0.0038 17.0 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 ORX59717.1 - 0.0051 16.6 0.0 0.008 16.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX59717.1 - 0.0052 16.2 0.0 0.07 12.5 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX59717.1 - 0.015 15.2 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 ORX59717.1 - 0.017 14.5 0.0 6.6 6.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial TniB protein Rad17 PF03215.15 ORX59717.1 - 0.021 14.8 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain MeaB PF03308.16 ORX59717.1 - 0.027 13.5 0.0 0.048 12.6 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_24 PF13479.6 ORX59717.1 - 0.03 14.0 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DNA_pol3_delta PF06144.13 ORX59717.1 - 0.037 13.8 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit DEAD PF00270.29 ORX59717.1 - 0.055 13.2 0.1 0.28 10.9 0.0 2.1 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_19 PF13245.6 ORX59717.1 - 0.068 13.5 0.1 0.24 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX59717.1 - 0.1 12.2 0.2 0.28 10.7 0.1 1.8 2 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ORX59717.1 - 0.12 12.3 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KTI12 PF08433.10 ORX59717.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NTPase_1 PF03266.15 ORX59717.1 - 0.15 12.0 0.0 0.83 9.5 0.0 2.0 2 0 0 2 2 2 0 NTPase DNA_ligase_A_M PF01068.21 ORX59718.1 - 7.2e-48 162.9 0.0 3.5e-47 160.7 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ORX59718.1 - 1.8e-33 116.3 0.0 3.2e-33 115.5 0.0 1.4 1 0 0 1 1 1 1 DNA ligase N terminus BRCT_2 PF16589.5 ORX59718.1 - 1.2e-19 70.5 0.0 2.7e-13 50.1 0.0 3.0 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 ORX59718.1 - 4.4e-12 46.5 0.1 1.6e-11 44.7 0.0 2.0 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 ORX59718.1 - 1.3e-11 45.1 0.0 3.2e-11 43.8 0.0 1.7 1 0 0 1 1 1 1 RNA ligase DNA_ligase_IV PF11411.8 ORX59718.1 - 6.1e-05 23.1 0.1 0.0002 21.4 0.1 1.9 1 0 0 1 1 1 1 DNA ligase IV mRNA_cap_enzyme PF01331.19 ORX59718.1 - 0.00083 19.2 0.1 0.012 15.5 0.0 2.5 1 1 0 1 1 1 1 mRNA capping enzyme, catalytic domain BRCT PF00533.26 ORX59718.1 - 0.00083 19.7 0.0 0.008 16.5 0.1 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Mitoc_mL59 PF18126.1 ORX59718.1 - 0.1 12.9 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ribosomal protein mL59 DUF1564 PF07600.11 ORX59718.1 - 0.18 11.5 2.5 0.4 10.3 2.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) YCII PF03795.14 ORX59720.1 - 1.3e-10 41.6 0.0 1.5e-10 41.4 0.0 1.0 1 0 0 1 1 1 1 YCII-related domain NMT1_2 PF13379.6 ORX59721.1 - 3.5e-07 30.2 0.0 7.5e-07 29.1 0.0 1.7 2 0 0 2 2 2 1 NMT1-like family NMT1 PF09084.11 ORX59721.1 - 1e-05 25.6 0.0 2e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 ORX59721.1 - 0.055 13.0 0.0 0.1 12.2 0.0 1.5 1 1 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Sulphotransf PF09037.10 ORX59721.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 Stf0 sulphotransferase YhhN PF07947.14 ORX59722.1 - 1.4e-32 112.8 10.9 1.7e-32 112.5 10.9 1.0 1 0 0 1 1 1 1 YhhN family Pertus-S4-tox PF09275.10 ORX59722.1 - 0.067 13.5 0.5 0.11 12.8 0.5 1.3 1 0 0 1 1 1 0 Pertussis toxin S4 subunit Polysacc_deac_1 PF01522.21 ORX59723.1 - 1.8e-10 40.8 0.0 2.7e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase CZB PF13682.6 ORX59724.1 - 0.02 15.3 0.3 0.037 14.5 0.0 1.5 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain NPV_P10 PF05531.12 ORX59724.1 - 0.031 14.7 0.2 0.055 13.9 0.1 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ORX59724.1 - 0.074 13.1 0.9 0.092 12.8 0.9 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) MFS_1 PF07690.16 ORX59725.1 - 2.4e-45 155.0 40.2 2.4e-45 155.0 40.2 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX59725.1 - 5e-08 32.2 14.7 5e-08 32.2 14.7 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter WI12 PF07107.11 ORX59725.1 - 0.16 12.1 0.2 0.34 11.0 0.2 1.4 1 0 0 1 1 1 0 Wound-induced protein WI12 TRM13 PF05206.14 ORX59726.1 - 9.7e-80 267.8 4.1 1.2e-79 267.5 4.1 1.1 1 0 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 ORX59726.1 - 1.2e-08 34.5 1.8 2.7e-08 33.4 1.8 1.6 1 0 0 1 1 1 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 ORX59726.1 - 4.3e-08 32.9 0.7 4.3e-08 32.9 0.7 2.1 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Ribosomal_S14 PF00253.21 ORX59727.1 - 1.6e-16 59.8 3.2 1.8e-16 59.6 3.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DAO PF01266.24 ORX59729.1 - 7.8e-12 45.4 0.1 2.8e-11 43.6 0.1 1.8 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX59729.1 - 0.067 13.4 0.2 0.21 11.8 0.2 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX59729.1 - 0.19 11.0 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aa_trans PF01490.18 ORX59730.1 - 1.1e-80 271.4 32.3 1.4e-80 271.1 32.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein YpmT PF17431.2 ORX59730.1 - 0.023 14.7 0.5 0.13 12.3 0.5 2.3 1 0 0 1 1 1 0 Uncharacterized YmpT-like RINGv PF12906.7 ORX59731.1 - 2.8e-14 52.9 13.8 2.8e-14 52.9 13.8 1.8 2 0 0 2 2 2 1 RING-variant domain zf-ANAPC11 PF12861.7 ORX59731.1 - 4.6 7.4 6.8 8.9 6.4 6.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PhoLip_ATPase_C PF16212.5 ORX59732.1 - 1e-69 235.1 35.9 1e-69 235.1 35.9 2.3 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX59732.1 - 6.2e-24 83.5 1.0 6.2e-24 83.5 1.0 2.5 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 ORX59732.1 - 4.7e-10 40.1 1.0 0.0014 19.0 0.1 3.4 3 1 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX59732.1 - 4.1e-09 36.4 0.0 1.8e-08 34.3 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ORX59732.1 - 2.2e-07 30.6 9.0 2.9e-07 30.2 0.0 3.7 4 1 0 4 4 4 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX59732.1 - 0.0016 18.3 0.1 0.005 16.6 0.2 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX59732.1 - 0.091 13.2 0.0 3 8.2 0.0 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Shisa PF13908.6 ORX59732.1 - 0.32 11.2 1.3 0.72 10.1 0.1 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF4404 PF14357.6 ORX59732.1 - 1.4 9.6 6.5 9.8 6.9 0.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF1770 PF08589.10 ORX59733.1 - 0.0037 18.2 0.1 0.0054 17.7 0.1 1.3 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) MTS PF05175.14 ORX59734.1 - 1.4e-08 34.5 0.0 2.2e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX59734.1 - 0.0012 19.5 0.0 0.0022 18.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX59734.1 - 0.0062 16.3 0.0 0.0088 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 ORX59734.1 - 0.011 15.4 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_12 PF08242.12 ORX59734.1 - 0.019 15.7 0.0 0.037 14.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 ORX59734.1 - 0.078 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF938 PF06080.12 ORX59734.1 - 0.1 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_11 PF08241.12 ORX59734.1 - 0.12 13.0 0.0 0.21 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_33 PF10017.9 ORX59734.1 - 0.13 11.3 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Methyltransf_24 PF13578.6 ORX59734.1 - 0.13 13.2 0.2 0.32 12.0 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain DAHP_synth_1 PF00793.20 ORX59735.1 - 1.2e-100 336.0 0.0 1.4e-100 335.8 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family RNA_pol_A_bac PF01000.26 ORX59736.1 - 8.1e-29 100.3 0.0 1.4e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 ORX59736.1 - 8.3e-22 76.4 0.0 1.3e-21 75.8 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain DPM2 PF07297.12 ORX59737.1 - 9.2e-20 70.7 2.4 9.2e-20 70.7 2.4 2.1 2 1 0 2 2 2 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4536 PF15055.6 ORX59737.1 - 0.18 12.1 0.1 0.18 12.1 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4536) DUF2937 PF11157.8 ORX59737.1 - 0.51 10.0 2.7 0.48 10.1 1.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2937) PIG-P PF08510.12 ORX59737.1 - 1.1 9.2 8.5 0.18 11.7 4.6 1.6 1 1 1 2 2 2 0 PIG-P Phage_holin_3_6 PF07332.11 ORX59737.1 - 2.5 8.2 7.7 30 4.7 7.7 2.0 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Ribosomal_S17e PF00833.18 ORX59738.1 - 9.4e-62 206.4 0.1 1.1e-61 206.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal S17 Hydrolase_3 PF08282.12 ORX59739.1 - 1.8e-55 188.5 0.0 2e-55 188.3 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ORX59739.1 - 2.7e-12 46.7 0.2 4.9e-06 26.3 0.1 2.9 2 1 1 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ORX59739.1 - 1.2e-07 32.2 0.3 0.026 14.8 0.0 3.3 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX59739.1 - 1.2e-06 29.0 0.3 0.32 11.4 0.0 3.3 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 ORX59739.1 - 0.00013 21.2 0.0 0.16 11.1 0.0 2.2 2 0 0 2 2 2 2 Trehalose-phosphatase HAD_2 PF13419.6 ORX59739.1 - 0.0072 16.4 0.0 0.32 11.0 0.0 2.7 2 1 1 3 3 3 1 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX59740.1 - 1.8e-54 185.1 0.0 2.1e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ORX59740.1 - 2.2e-13 50.3 0.4 2e-05 24.3 0.1 2.8 2 1 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase PF00702.26 ORX59740.1 - 7.2e-08 33.0 0.1 0.0036 17.6 0.0 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Trehalose_PPase PF02358.16 ORX59740.1 - 1.7e-05 24.1 0.0 0.066 12.3 0.0 2.2 2 0 0 2 2 2 2 Trehalose-phosphatase HAD_2 PF13419.6 ORX59740.1 - 0.00024 21.2 0.1 0.049 13.7 0.1 2.6 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ORX59740.1 - 0.001 19.5 0.6 0.81 10.1 0.0 3.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ORX59740.1 - 0.016 15.3 0.0 0.058 13.5 0.0 2.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase HTH_29 PF13551.6 ORX59740.1 - 0.062 13.3 0.1 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn helix Sigma70_r4 PF04545.16 ORX59740.1 - 0.068 12.7 0.1 0.26 10.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 hnRNP_Q_AcD PF18360.1 ORX59740.1 - 0.11 12.5 0.0 0.29 11.1 0.0 1.8 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain HTH_7 PF02796.15 ORX59740.1 - 0.11 12.5 0.1 0.27 11.3 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase C2 PF00168.30 ORX59741.1 - 2.3e-79 262.3 1.7 3.6e-19 69.0 0.1 5.5 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 ORX59741.1 - 1.3e-05 24.8 0.1 5.6e-05 22.7 0.1 2.1 2 1 0 2 2 2 1 Synaptotagmin-like mitochondrial-lipid-binding domain zf-RVT PF13966.6 ORX59743.1 - 5.3e-07 30.3 0.2 1e-06 29.4 0.2 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase zf-RING_4 PF14570.6 ORX59743.1 - 0.24 11.2 1.0 0.41 10.5 1.0 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF2408 PF10303.9 ORX59745.1 - 7.8e-42 143.0 0.4 9.2e-25 87.8 0.0 4.6 2 2 2 4 4 4 3 Protein of unknown function (DUF2408) ING PF12998.7 ORX59746.1 - 3.9e-13 49.8 2.8 3.9e-13 49.8 2.8 1.6 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 ORX59746.1 - 1e-05 25.3 7.1 1.9e-05 24.4 7.1 1.5 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ORX59746.1 - 0.0046 16.5 2.7 0.01 15.4 2.7 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ORX59746.1 - 0.0059 16.8 0.7 0.015 15.6 0.7 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain RRN3 PF05327.11 ORX59747.1 - 0.12 10.9 1.1 0.11 11.0 1.1 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ORX59747.1 - 0.26 9.5 5.3 0.3 9.2 5.3 1.1 1 0 0 1 1 1 0 Nop14-like family HEXIM PF15313.6 ORX59747.1 - 0.84 9.8 6.9 2.9 8.1 7.0 1.7 1 1 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein DNA_pol_phi PF04931.13 ORX59747.1 - 1.1 7.2 10.7 1.4 7.0 10.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 ORX59747.1 - 1.3 8.6 8.7 2.2 7.8 8.7 1.3 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 ORX59747.1 - 4.9 6.8 12.5 7 6.3 12.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 ORX59747.1 - 9.8 5.2 13.9 14 4.7 13.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DEAD PF00270.29 ORX59748.1 - 2.7e-10 40.3 0.0 7.7e-09 35.6 0.0 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX59748.1 - 1.5e-09 38.2 0.0 4.5e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Sec63 PF02889.16 ORX59748.1 - 3.9e-07 29.5 0.0 6e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Sec63 Brl domain ResIII PF04851.15 ORX59748.1 - 0.00014 21.9 0.0 0.00029 20.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Adeno_IVa2 PF02456.15 ORX59748.1 - 0.00076 18.4 0.0 0.0012 17.7 0.0 1.2 1 0 0 1 1 1 1 Adenovirus IVa2 protein AAA_30 PF13604.6 ORX59748.1 - 0.0012 18.6 0.0 0.0026 17.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ORX59748.1 - 0.0037 17.1 0.0 0.18 11.6 0.0 2.6 2 0 0 2 2 2 1 Helicase AAA_23 PF13476.6 ORX59748.1 - 0.043 14.3 0.1 0.087 13.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain DUF3937 PF13073.6 ORX59748.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3937) AAA_16 PF13191.6 ORX59748.1 - 0.17 12.3 0.0 0.43 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain HHH_5 PF14520.6 ORX59749.1 - 0.00017 22.1 0.0 0.00031 21.3 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix domain Cdd1 PF11731.8 ORX59749.1 - 0.002 18.3 0.0 0.004 17.3 0.0 1.4 1 0 0 1 1 1 1 Pathogenicity locus DNA_pol_lambd_f PF10391.9 ORX59749.1 - 0.0023 17.7 0.0 0.013 15.3 0.0 2.1 2 0 0 2 2 2 1 Fingers domain of DNA polymerase lambda HHH PF00633.23 ORX59749.1 - 0.02 14.7 0.0 0.049 13.5 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix motif TfoX_C PF04994.13 ORX59749.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 TfoX C-terminal domain WD40_4 PF16300.5 ORX59750.1 - 1.3e-28 98.6 0.1 1.3e-16 60.1 0.0 2.6 2 0 0 2 2 2 2 Type of WD40 repeat DUF1899 PF08953.11 ORX59750.1 - 8.6e-20 70.4 0.0 2.6e-10 40.0 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1899) WD40 PF00400.32 ORX59750.1 - 3.9e-10 40.2 24.6 0.0047 17.7 0.1 7.8 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX59750.1 - 3.5e-06 27.2 1.5 0.00022 21.5 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX59750.1 - 0.00011 21.3 0.1 0.12 11.3 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Chromo PF00385.24 ORX59751.1 - 4.9e-12 45.6 1.9 8.4e-12 44.8 1.9 1.4 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Chromo_shadow PF01393.19 ORX59751.1 - 1.2e-07 31.7 0.1 2.1e-05 24.5 0.0 2.4 2 0 0 2 2 2 2 Chromo shadow domain Acyltransferase PF01553.21 ORX59752.1 - 4.2e-14 52.3 0.0 6.7e-14 51.7 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase MMR_HSR1 PF01926.23 ORX59753.1 - 7e-21 74.4 0.1 1.2e-20 73.7 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX59753.1 - 1.2e-11 44.8 0.2 2.5e-05 24.3 0.1 2.2 1 1 1 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ORX59753.1 - 2.1e-11 43.6 0.0 3.1e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B cobW PF02492.19 ORX59753.1 - 9e-08 31.9 0.3 1e-05 25.2 0.0 2.4 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain GTP_EFTU PF00009.27 ORX59753.1 - 2.4e-07 30.5 0.0 4.8e-06 26.3 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX59753.1 - 4.1e-07 30.2 0.8 6.5e-05 23.1 0.2 2.3 1 1 1 2 2 2 1 Dynamin family KH_2 PF07650.17 ORX59753.1 - 3.3e-06 26.8 0.0 6.6e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 KH domain AIG1 PF04548.16 ORX59753.1 - 0.00043 19.7 0.0 0.00068 19.0 0.0 1.4 1 0 0 1 1 1 1 AIG1 family TniB PF05621.11 ORX59753.1 - 0.0056 16.1 0.0 0.023 14.1 0.0 2.0 1 1 0 1 1 1 1 Bacterial TniB protein PduV-EutP PF10662.9 ORX59753.1 - 0.012 15.4 0.0 0.16 11.7 0.0 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 ORX59753.1 - 0.023 14.1 0.2 0.12 11.8 0.2 2.0 1 1 0 1 1 1 0 ADP-ribosylation factor family MeaB PF03308.16 ORX59753.1 - 0.027 13.5 0.0 0.76 8.7 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ORX59753.1 - 0.027 15.0 0.0 0.056 14.0 0.0 1.6 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 ORX59753.1 - 0.048 13.4 0.1 0.6 9.9 0.1 2.2 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1_Xtn PF16897.5 ORX59753.1 - 0.049 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Roc PF08477.13 ORX59753.1 - 0.05 13.8 0.0 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 ORX59753.1 - 0.062 13.5 0.2 0.17 12.1 0.0 1.8 2 1 0 2 2 2 0 AAA domain SRPRB PF09439.10 ORX59753.1 - 0.069 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Guanylate_kin PF00625.21 ORX59753.1 - 0.07 12.8 0.1 0.64 9.7 0.0 2.3 2 0 0 2 2 2 0 Guanylate kinase GATA PF00320.27 ORX59754.1 - 1.4e-15 56.6 4.1 2.5e-15 55.8 4.1 1.4 1 0 0 1 1 1 1 GATA zinc finger SCA7 PF08313.12 ORX59755.1 - 1.6e-30 104.8 0.8 3.6e-30 103.6 0.8 1.5 1 0 0 1 1 1 1 SCA7, zinc-binding domain Sgf11 PF08209.11 ORX59755.1 - 0.0021 17.5 0.2 0.0037 16.8 0.2 1.4 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) Oxidored_molyb PF00174.19 ORX59756.1 - 6e-52 175.7 0.0 1.3e-51 174.7 0.0 1.5 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ORX59756.1 - 7.1e-31 107.1 0.9 1.2e-30 106.4 0.9 1.3 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain SWIM PF04434.17 ORX59757.1 - 0.69 9.6 10.4 2.6 7.8 10.4 1.9 1 1 0 1 1 1 0 SWIM zinc finger Kelch_4 PF13418.6 ORX59758.1 - 2e-37 126.9 9.0 2.2e-08 34.0 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX59758.1 - 6.5e-36 121.8 12.6 1.2e-06 28.3 0.0 6.2 6 0 0 6 6 6 6 Kelch motif Kelch_1 PF01344.25 ORX59758.1 - 2.3e-34 116.7 13.2 4.3e-06 26.2 0.2 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ORX59758.1 - 2.8e-34 116.8 22.3 5.1e-09 36.2 0.1 7.9 7 1 0 7 7 7 6 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX59758.1 - 1.4e-30 104.5 15.7 4.5e-08 33.1 0.0 6.6 3 2 3 6 6 6 5 Kelch motif Kelch_2 PF07646.15 ORX59758.1 - 6.8e-28 95.6 13.0 2.7e-05 23.9 0.0 6.5 6 1 0 6 6 6 6 Kelch motif PQQ_3 PF13570.6 ORX59758.1 - 0.097 13.2 11.8 14 6.3 0.1 5.2 5 0 0 5 5 5 0 PQQ-like domain SSB PF00436.25 ORX59759.1 - 3.5e-25 88.0 0.1 4.6e-25 87.7 0.1 1.2 1 0 0 1 1 1 1 Single-strand binding protein family tRNA_anti-codon PF01336.25 ORX59759.1 - 0.0028 17.6 0.0 0.0063 16.5 0.0 1.6 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain zf-C3H1 PF10650.9 ORX59760.1 - 5e-08 32.5 1.3 7.6e-08 31.9 1.3 1.3 1 0 0 1 1 1 1 Putative zinc-finger domain CaMBD PF02888.16 ORX59760.1 - 0.075 13.2 1.8 0.13 12.4 1.8 1.3 1 0 0 1 1 1 0 Calmodulin binding domain CDC45 PF02724.14 ORX59761.1 - 2e-198 660.7 15.6 2.6e-197 657.0 15.6 1.9 1 1 0 1 1 1 1 CDC45-like protein DUF1543 PF07566.12 ORX59761.1 - 0.026 14.2 0.4 0.09 12.5 0.1 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1543) DUF667 PF05018.13 ORX59762.1 - 1.3e-74 249.9 0.1 1.5e-74 249.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF667) DUF1539 PF07560.11 ORX59762.1 - 0.14 12.2 0.1 16 5.6 0.0 2.2 1 1 0 2 2 2 0 Domain of Unknown Function (DUF1539) COQ7 PF03232.13 ORX59763.1 - 3.4e-79 264.6 0.3 4e-79 264.4 0.3 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Ferritin_2 PF13668.6 ORX59763.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.4 1 1 0 1 1 1 1 Ferritin-like domain DUF2713 PF10897.8 ORX59763.1 - 0.027 14.1 0.1 1.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2713) Rubrerythrin PF02915.17 ORX59763.1 - 0.03 14.7 0.0 0.074 13.5 0.0 1.6 1 1 0 1 1 1 0 Rubrerythrin RIC3 PF15361.6 ORX59764.1 - 0.041 14.3 1.0 0.064 13.6 1.0 1.5 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF1241 PF06840.11 ORX59764.1 - 0.085 12.5 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1241) Nucleoporin_FG PF13634.6 ORX59764.1 - 0.11 13.3 1.0 1.2 10.1 0.1 2.1 2 0 0 2 2 2 0 Nucleoporin FG repeat region HLH PF00010.26 ORX59766.1 - 1.3e-14 53.9 1.7 2.7e-14 52.9 1.7 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Tail_P2_I PF09684.10 ORX59766.1 - 0.052 13.5 0.3 0.16 11.9 0.1 1.9 1 1 0 1 1 1 0 Phage tail protein (Tail_P2_I) YabA PF06156.13 ORX59766.1 - 2.4 8.8 8.5 0.9 10.2 3.2 2.4 1 1 2 3 3 3 0 Initiation control protein YabA NIF PF03031.18 ORX59768.1 - 2.5e-26 92.3 0.2 4.5e-26 91.5 0.2 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 ORX59768.1 - 8.3e-06 26.1 0.0 2.5e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ORX59768.1 - 0.0019 18.6 0.1 0.0045 17.4 0.1 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ORX59768.1 - 0.0094 16.2 0.4 0.023 15.0 0.4 1.6 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 ORX59768.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 twin BRCT domain tRNA_bind_2 PF13725.6 ORX59768.1 - 0.6 9.8 7.1 0.058 13.1 1.0 2.1 2 0 0 2 2 2 0 Possible tRNA binding domain OrfB_Zn_ribbon PF07282.11 ORX59770.1 - 0.00081 19.3 0.8 0.0017 18.3 0.8 1.5 1 1 0 1 1 1 1 Putative transposase DNA-binding domain UCH PF00443.29 ORX59773.1 - 5e-49 167.1 0.6 6.8e-49 166.7 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX59773.1 - 3.9e-22 79.2 0.7 2.2e-21 76.8 0.7 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX59773.1 - 1.1e-12 48.0 0.1 4.3e-12 46.2 0.0 2.1 2 1 0 2 2 2 1 MATH domain EF-hand_13 PF17958.1 ORX59774.1 - 2.1e-23 81.9 1.1 8.1e-23 80.0 0.0 2.4 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 ORX59774.1 - 4.2e-12 46.4 2.6 9.9e-12 45.1 0.7 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ORX59774.1 - 0.0015 18.3 2.6 0.016 15.1 0.0 3.6 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 ORX59774.1 - 0.0041 16.6 1.1 0.025 14.1 0.0 2.9 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.6 ORX59774.1 - 0.0086 15.5 0.0 0.022 14.2 0.0 1.7 1 0 0 1 1 1 1 EF hand SPARC_Ca_bdg PF10591.9 ORX59774.1 - 0.014 15.7 2.0 4.4 7.7 0.3 3.0 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Fungal_trans PF04082.18 ORX59775.1 - 1.3e-17 63.7 2.5 1.3e-17 63.7 2.5 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain CAS_C PF12026.8 ORX59775.1 - 4.2 7.4 5.7 1 9.4 0.3 2.2 2 0 0 2 2 2 0 Crk-Associated Substrate C-terminal domain zf-C2H2 PF00096.26 ORX59776.1 - 3.4e-08 33.5 8.5 1.3e-05 25.4 2.5 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 ORX59776.1 - 0.00036 21.1 1.1 0.43 11.3 0.2 2.2 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX59776.1 - 0.00074 20.1 7.2 0.045 14.6 1.7 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX59776.1 - 0.0043 17.4 2.4 0.0043 17.4 2.4 2.4 2 0 0 2 2 2 1 Zinc-finger double domain GST_N_3 PF13417.6 ORX59779.1 - 1.8e-17 63.5 0.0 3.8e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ORX59779.1 - 2e-14 53.7 0.0 4.6e-14 52.5 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ORX59779.1 - 5e-14 52.4 0.0 8.3e-14 51.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ORX59779.1 - 1.4e-07 31.6 0.0 2.7e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX59779.1 - 8.5e-06 25.7 0.0 1.8e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX59779.1 - 1.2e-05 25.4 0.0 2e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ORX59779.1 - 0.0016 18.7 0.0 0.0028 18.0 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 ORX59779.1 - 0.0093 16.7 0.0 0.02 15.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain Methyltransf_16 PF10294.9 ORX59780.1 - 1.9e-26 92.9 0.0 2.6e-26 92.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 ORX59780.1 - 0.00056 19.7 0.0 0.0014 18.5 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX59780.1 - 0.0016 18.0 0.0 0.0026 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX59780.1 - 0.0025 17.7 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX59780.1 - 0.078 13.7 0.0 0.17 12.6 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ORX59780.1 - 0.13 13.0 0.0 0.29 11.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Clathrin_lg_ch PF01086.17 ORX59781.1 - 5.7e-43 147.6 19.1 1e-42 146.8 19.1 1.4 1 1 0 1 1 1 1 Clathrin light chain Hamartin PF04388.12 ORX59781.1 - 0.013 14.2 4.2 0.016 13.9 4.2 1.0 1 0 0 1 1 1 0 Hamartin protein rve_3 PF13683.6 ORX59781.1 - 1.5 8.7 3.8 0.55 10.1 0.6 1.9 2 0 0 2 2 2 0 Integrase core domain DUF4337 PF14235.6 ORX59781.1 - 2.3 8.3 8.1 3.7 7.6 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF501 PF04417.12 ORX59781.1 - 2.3 8.0 4.9 0.64 9.8 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF501) DUF4407 PF14362.6 ORX59781.1 - 3.5 6.9 8.6 1.7 7.9 6.8 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Cadherin_pro PF08758.11 ORX59783.1 - 0.048 13.8 0.0 0.072 13.3 0.0 1.3 1 0 0 1 1 1 0 Cadherin prodomain like Baculo_E66 PF04850.12 ORX59784.1 - 0.079 11.7 0.0 0.086 11.6 0.0 1.0 1 0 0 1 1 1 0 Baculovirus E66 occlusion-derived virus envelope protein OrfB_Zn_ribbon PF07282.11 ORX59785.1 - 5.9e-06 26.1 1.6 1e-05 25.4 1.6 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OSR1_C PF12202.8 ORX59786.1 - 0.027 14.7 0.4 0.078 13.2 0.2 2.0 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain NuiA PF07924.11 ORX59787.1 - 3.1e-08 34.1 0.2 0.0031 17.9 0.0 2.1 1 1 1 2 2 2 2 Nuclease A inhibitor-like protein YABBY PF04690.13 ORX59788.1 - 3e-13 50.7 0.9 3.1e-13 50.6 0.9 1.0 1 0 0 1 1 1 1 YABBY protein Ccdc124 PF06244.12 ORX59788.1 - 5.6e-06 26.9 2.5 6.2e-06 26.8 2.5 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 HMG_box PF00505.19 ORX59788.1 - 6.2e-06 26.5 1.6 7.5e-06 26.3 1.6 1.1 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX59788.1 - 0.00015 22.3 1.5 0.00017 22.1 1.5 1.1 1 0 0 1 1 1 1 HMG-box domain PX PF00787.24 ORX59790.1 - 2.7e-27 95.0 0.1 3.3e-27 94.7 0.1 1.1 1 0 0 1 1 1 1 PX domain Aminotran_1_2 PF00155.21 ORX59791.1 - 1.2e-88 297.7 0.0 1.4e-88 297.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II TetR_C_35 PF18556.1 ORX59792.1 - 0.092 12.9 0.4 0.33 11.1 0.0 2.1 2 0 0 2 2 2 0 Bacterial Tetracyclin repressor, C-terminal domain Pex24p PF06398.11 ORX59793.1 - 4.6e-26 91.7 23.8 1.1e-24 87.1 23.8 2.1 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin C1_1 PF00130.22 ORX59793.1 - 6.8e-11 41.9 8.4 1.2e-10 41.0 8.4 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Reticulon PF02453.17 ORX59793.1 - 0.11 12.4 1.3 0.18 11.7 1.3 1.4 1 0 0 1 1 1 0 Reticulon PHD PF00628.29 ORX59793.1 - 0.13 12.2 7.6 0.31 11.0 7.6 1.7 1 0 0 1 1 1 0 PHD-finger Aa_trans PF01490.18 ORX59794.1 - 3.7e-39 134.6 18.0 4.3e-39 134.4 18.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein GATA PF00320.27 ORX59795.1 - 2.4e-18 65.4 1.0 4.6e-18 64.5 1.0 1.5 1 0 0 1 1 1 1 GATA zinc finger DUF1752 PF08550.10 ORX59795.1 - 6.9e-13 48.2 0.4 1.5e-12 47.1 0.4 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) TFIIS_M PF07500.14 ORX59796.1 - 1.3e-23 83.6 0.0 2.6e-23 82.6 0.0 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 ORX59796.1 - 7.6e-20 70.5 8.6 7.6e-20 70.5 8.6 1.7 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 ORX59796.1 - 7.9e-11 41.8 0.4 2.6e-10 40.2 0.4 1.9 2 0 0 2 2 2 1 TFIIS helical bundle-like domain LEDGF PF11467.8 ORX59796.1 - 0.011 15.4 0.3 0.023 14.3 0.3 1.7 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) PH PF00169.29 ORX59799.1 - 9.7e-06 26.0 0.1 1.7e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 PH domain RA PF00788.23 ORX59799.1 - 7.2e-05 23.3 0.1 0.0002 21.9 0.1 1.7 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain CBFB_NFYA PF02045.15 ORX59801.1 - 2e-29 102.0 6.1 3.3e-29 101.3 6.1 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B SKA1 PF07160.12 ORX59801.1 - 0.057 13.3 0.2 0.087 12.7 0.2 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Ribosomal_60s PF00428.19 ORX59801.1 - 7.3 7.3 8.0 2.9 8.5 4.1 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein LINES_N PF14694.6 ORX59802.1 - 2.8e-10 40.2 3.3 3.6e-10 39.9 2.2 1.6 1 1 0 1 1 1 1 Lines N-terminus LINES_C PF14695.6 ORX59802.1 - 0.049 13.1 0.0 0.16 11.4 0.0 1.9 1 0 0 1 1 1 0 Lines C-terminus Red1 PF07964.11 ORX59803.1 - 1.4 7.1 16.6 1.8 6.7 16.6 1.1 1 0 0 1 1 1 0 Rec10 / Red1 JTB PF05439.12 ORX59805.1 - 3.3e-10 40.0 7.3 5.7e-09 36.0 7.3 2.0 1 1 0 1 1 1 1 Jumping translocation breakpoint protein (JTB) Abhydrolase_1 PF00561.20 ORX59806.1 - 0.00021 21.0 1.2 0.0011 18.6 1.2 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX59806.1 - 0.00042 19.7 0.1 0.0019 17.5 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX59806.1 - 0.00069 20.3 0.1 0.001 19.7 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ndr PF03096.14 ORX59806.1 - 0.0033 16.2 0.0 0.0044 15.8 0.0 1.2 1 0 0 1 1 1 1 Ndr family Thioesterase PF00975.20 ORX59806.1 - 0.0034 17.5 0.1 0.0053 16.9 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ORX59806.1 - 0.013 15.3 0.1 0.022 14.6 0.1 1.5 1 1 0 1 1 1 0 Lipase (class 3) Abhydrolase_8 PF06259.12 ORX59806.1 - 0.043 13.4 0.1 0.07 12.8 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Acyl_transf_1 PF00698.21 ORX59806.1 - 0.063 12.8 0.1 0.093 12.2 0.1 1.2 1 0 0 1 1 1 0 Acyl transferase domain Ser_hydrolase PF06821.13 ORX59806.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Serine hydrolase DNA_ligase_A_M PF01068.21 ORX59807.1 - 6.1e-62 208.9 0.1 1.1e-61 208.0 0.1 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ORX59807.1 - 1.5e-37 129.5 1.0 8.9e-37 127.1 1.0 2.3 1 1 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ORX59807.1 - 5.4e-26 91.1 0.0 2.6e-25 88.9 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region HTH_40 PF14493.6 ORX59807.1 - 0.064 13.7 2.6 0.99 9.9 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain PP1_inhibitor PF05361.12 ORX59807.1 - 0.18 11.8 1.3 1.2 9.2 0.1 2.5 2 0 0 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor WD40 PF00400.32 ORX59808.1 - 3.7e-34 116.2 19.8 1.5e-05 25.6 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ATG16 PF08614.11 ORX59808.1 - 6.2e-34 118.0 31.4 6.2e-34 118.0 31.4 2.6 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) ANAPC4_WD40 PF12894.7 ORX59808.1 - 4e-10 39.9 0.1 0.49 10.7 0.0 5.8 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX59808.1 - 2.5e-05 23.4 0.5 0.7 8.8 0.0 4.3 2 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ORX59808.1 - 0.00067 19.1 0.0 0.23 10.8 0.1 2.7 2 0 0 2 2 2 2 WD40-like domain Rx_N PF18052.1 ORX59808.1 - 0.004 17.4 0.8 0.004 17.4 0.8 1.9 2 0 0 2 2 2 1 Rx N-terminal domain YabA PF06156.13 ORX59808.1 - 0.011 16.4 4.9 0.011 16.4 4.9 2.9 1 1 1 2 2 2 0 Initiation control protein YabA Nup160 PF11715.8 ORX59808.1 - 0.011 14.4 11.5 1.3 7.6 0.1 4.0 2 1 1 4 4 4 0 Nucleoporin Nup120/160 DNA_binding_1 PF01035.20 ORX59808.1 - 0.12 12.5 0.2 0.27 11.4 0.2 1.6 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, DNA binding domain PNK3P PF08645.11 ORX59808.1 - 1.7 8.3 9.2 45 3.7 9.2 2.3 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase FlaC_arch PF05377.11 ORX59808.1 - 3.5 8.1 4.8 2.8 8.4 0.5 2.8 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) ECH_1 PF00378.20 ORX59809.1 - 1.9e-59 201.0 0.0 2.2e-59 200.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX59809.1 - 9.6e-32 110.8 0.0 5.7e-28 98.4 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase FIVAR PF07554.13 ORX59809.1 - 0.002 18.8 0.1 2.1 9.1 0.0 2.6 2 0 0 2 2 2 2 FIVAR domain AA_permease PF00324.21 ORX59810.1 - 2.9e-129 431.8 48.8 3.5e-129 431.5 48.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX59810.1 - 1e-39 136.6 52.9 1.3e-39 136.3 52.9 1.1 1 0 0 1 1 1 1 Amino acid permease Chitin_synth_1 PF01644.17 ORX59812.1 - 1.5e-71 239.6 0.1 2.5e-71 238.9 0.1 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 ORX59812.1 - 1.1e-21 76.5 0.0 5.4e-21 74.3 0.0 2.2 2 0 0 2 2 2 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 ORX59812.1 - 1.2e-20 73.7 0.0 1.4e-15 57.0 0.0 2.5 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX59812.1 - 3.1e-06 27.3 7.0 2.4e-05 24.3 7.0 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX59812.1 - 0.0061 16.5 0.0 0.017 15.0 0.0 1.8 1 1 1 2 2 2 1 Glycosyltransferase like family 2 MHYT PF03707.16 ORX59813.1 - 4.7e-27 93.9 13.2 8.2e-11 41.9 0.6 4.6 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat DUF4407 PF14362.6 ORX59813.1 - 0.19 11.1 1.8 0.47 9.8 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Abhydrolase_9_N PF15420.6 ORX59813.1 - 1.1 9.2 6.6 0.38 10.7 2.5 2.2 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Peptidase_U4 PF03419.13 ORX59813.1 - 2.4 7.4 12.0 0.4 9.9 5.8 2.1 1 1 1 2 2 2 0 Sporulation factor SpoIIGA AMP-binding PF00501.28 ORX59814.1 - 2.5e-99 332.8 0.0 3.6e-99 332.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX59814.1 - 7.2e-06 26.9 0.3 2.5e-05 25.2 0.3 2.0 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain DAHP_synth_1 PF00793.20 ORX59815.1 - 1.1e-101 339.3 0.0 1.3e-101 339.1 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Sas10 PF09368.10 ORX59816.1 - 1.5e-27 95.8 7.3 1.5e-27 95.8 7.3 2.6 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 ORX59816.1 - 9.3e-10 39.0 0.3 9.3e-10 39.0 0.3 2.8 2 1 0 2 2 2 1 Sas10/Utp3/C1D family RelB_transactiv PF16181.5 ORX59816.1 - 0.2 11.9 0.4 0.42 10.8 0.4 1.5 1 0 0 1 1 1 0 RelB transactivation domain Bud13 PF09736.9 ORX59817.1 - 9.4e-48 162.3 8.7 9.4e-48 162.3 8.7 2.6 3 0 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Homeodomain PF00046.29 ORX59818.1 - 2e-16 59.6 0.6 3.4e-16 58.8 0.6 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX59818.1 - 0.0024 17.7 0.0 0.0057 16.5 0.0 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.6 ORX59818.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain Pyrophosphatase PF00719.19 ORX59819.1 - 1.1e-57 194.4 0.6 1.4e-57 194.0 0.6 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase PHP PF02811.19 ORX59820.1 - 5.5e-12 46.3 0.0 8.8e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 PHP domain BCDHK_Adom3 PF10436.9 ORX59821.1 - 2.1e-40 138.2 0.0 5e-40 137.0 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX59821.1 - 2.8e-07 31.0 0.0 2.9e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 ORX59821.1 - 0.023 14.6 0.0 0.053 13.5 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain Kelch_5 PF13854.6 ORX59822.1 - 8.6e-08 32.0 13.0 0.0075 16.2 0.1 4.9 5 0 0 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ORX59822.1 - 3.4e-07 30.2 15.2 0.0081 16.2 0.9 5.4 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX59822.1 - 2.4e-05 23.8 3.2 0.0011 18.5 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ORX59822.1 - 0.0023 18.1 10.0 1.8 9.0 0.0 4.8 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ORX59822.1 - 5.4 7.2 11.1 3.3 7.8 0.7 4.9 5 1 0 5 5 5 0 Kelch motif Questin_oxidase PF14027.6 ORX59824.1 - 4.6e-86 289.4 1.5 5.4e-86 289.2 1.5 1.0 1 0 0 1 1 1 1 Questin oxidase-like Glyco_hydro_15 PF00723.21 ORX59825.1 - 1.9e-49 168.7 2.8 2.5e-49 168.3 2.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Trefoil PF00088.18 ORX59825.1 - 2e-38 130.0 36.1 4.8e-14 52.0 7.6 3.5 3 0 0 3 3 3 3 Trefoil (P-type) domain Imm31 PF15591.6 ORX59825.1 - 0.081 12.8 0.2 9.2 6.2 0.1 2.6 2 0 0 2 2 2 0 Immunity protein 31 Kringle PF00051.18 ORX59825.1 - 1.1 9.7 20.8 2 8.8 0.4 4.6 5 0 0 5 5 5 0 Kringle domain MFS18 PF17352.2 ORX59826.1 - 0.0084 16.5 3.8 0.016 15.5 3.8 1.5 1 0 0 1 1 1 1 Male Flower Specific protein 18 AP3D1 PF06375.11 ORX59826.1 - 1.2 9.3 11.2 0.093 13.0 5.3 2.1 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 Peptidase_S64 PF08192.11 ORX59826.1 - 2.1 6.7 6.2 2.7 6.4 6.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 FAM76 PF16046.5 ORX59826.1 - 4.1 6.7 8.8 5.7 6.2 8.8 1.2 1 0 0 1 1 1 0 FAM76 protein Questin_oxidase PF14027.6 ORX59827.1 - 2.9e-07 30.3 0.0 3.3e-07 30.2 0.0 1.0 1 0 0 1 1 1 1 Questin oxidase-like DUF3507 PF12015.8 ORX59828.1 - 0.079 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Questin_oxidase PF14027.6 ORX59829.1 - 2.7e-74 250.7 0.9 3.2e-74 250.5 0.9 1.1 1 0 0 1 1 1 1 Questin oxidase-like zf-RING_2 PF13639.6 ORX59830.1 - 6.4e-08 32.8 4.0 1.8e-07 31.3 4.0 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX59830.1 - 3.3e-06 27.0 2.5 1.1e-05 25.4 2.5 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX59830.1 - 3.2e-05 23.7 2.0 8.9e-05 22.3 2.0 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX59830.1 - 3.2e-05 23.7 4.0 3.2e-05 23.7 4.0 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX59830.1 - 0.0001 22.2 3.7 0.00036 20.4 3.7 2.0 1 0 0 1 1 1 1 zinc-RING finger domain Rtf2 PF04641.12 ORX59830.1 - 0.00033 20.1 1.1 0.00055 19.4 1.1 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger zf-RING_11 PF17123.5 ORX59830.1 - 0.0007 19.3 1.0 0.0021 17.8 1.0 1.9 1 0 0 1 1 1 1 RING-like zinc finger Prok-RING_4 PF14447.6 ORX59830.1 - 0.00082 19.2 2.1 0.0018 18.1 2.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ORX59830.1 - 0.00083 19.4 0.9 0.0029 17.6 0.9 2.0 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 ORX59830.1 - 0.00085 19.6 2.4 0.0025 18.0 2.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ORX59830.1 - 0.0013 18.8 3.6 0.0018 18.4 1.6 2.3 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ORX59830.1 - 0.0017 18.1 0.8 0.0054 16.5 0.8 1.9 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_2 PF13923.6 ORX59830.1 - 0.0043 16.9 5.2 0.012 15.5 4.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-TFIIIC PF12660.7 ORX59830.1 - 0.0048 16.8 1.6 0.021 14.7 0.3 2.4 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex Baculo_IE-1 PF05290.11 ORX59830.1 - 0.0059 16.6 0.1 0.013 15.5 0.1 1.6 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-C2H2_4 PF13894.6 ORX59830.1 - 0.011 16.5 1.0 11 7.2 0.1 3.1 2 0 0 2 2 2 0 C2H2-type zinc finger STAT_alpha PF01017.20 ORX59830.1 - 0.082 12.8 4.8 0.062 13.2 2.9 1.6 2 0 0 2 2 2 0 STAT protein, all-alpha domain T3SSipB PF16535.5 ORX59830.1 - 0.091 13.2 4.1 0.17 12.3 4.1 1.4 1 0 0 1 1 1 0 Type III cell invasion protein SipB FYVE PF01363.21 ORX59830.1 - 0.41 10.8 4.0 2.8 8.1 4.0 2.2 1 1 0 1 1 1 0 FYVE zinc finger Sugar_tr PF00083.24 ORX59832.1 - 4.9e-92 309.1 22.9 6.1e-92 308.8 22.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX59832.1 - 1.5e-31 109.6 48.2 8.3e-30 103.9 18.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Tom22 PF04281.13 ORX59833.1 - 1.3e-35 122.1 3.2 1.9e-35 121.7 3.2 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Nse5 PF08691.10 ORX59833.1 - 0.011 14.4 0.1 0.014 14.1 0.1 1.1 1 0 0 1 1 1 0 DNA repair proteins Nse5 and Nse6 Radial_spoke PF04712.12 ORX59834.1 - 0.38 9.7 4.6 0.44 9.4 4.6 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Pep1_7 PF17232.2 ORX59834.1 - 0.66 10.5 7.4 1 9.9 7.4 1.3 1 0 0 1 1 1 0 Elicitor peptide 1-7 ODC_AZ PF02100.17 ORX59835.1 - 8.5e-11 41.8 0.0 9.8e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme ATP-synt_D PF01813.17 ORX59835.1 - 0.0095 15.8 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 1 ATP synthase subunit D Steroid_dh PF02544.16 ORX59836.1 - 3.7e-36 124.4 9.1 6e-36 123.7 9.1 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase YukD PF08817.10 ORX59836.1 - 2.8e-05 24.7 0.2 4.5e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD ubiquitin PF00240.23 ORX59836.1 - 0.00013 21.6 0.2 0.00029 20.5 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin family UAE_UbL PF14732.6 ORX59836.1 - 0.012 16.2 0.0 0.022 15.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Ubiquitin_2 PF14560.6 ORX59836.1 - 0.1 13.1 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD PF11976.8 ORX59836.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like HAMP PF00672.25 ORX60235.1 - 2e-118 386.7 48.0 3.9e-08 33.6 0.1 17.1 17 0 0 17 17 16 15 HAMP domain HATPase_c PF02518.26 ORX60235.1 - 1.3e-30 106.2 0.2 7.8e-30 103.7 0.2 2.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 ORX60235.1 - 7.4e-23 80.9 3.5 1.8e-22 79.6 0.3 3.7 3 0 0 3 3 3 1 Response regulator receiver domain HisKA PF00512.25 ORX60235.1 - 3e-17 62.4 3.9 1e-16 60.7 0.5 4.1 3 0 0 3 3 2 1 His Kinase A (phospho-acceptor) domain HTH_6 PF01418.17 ORX60235.1 - 5.9e-11 42.2 5.1 62 3.7 0.0 12.6 13 0 0 13 13 13 0 Helix-turn-helix domain, rpiR family HMG_box PF00505.19 ORX60235.1 - 1.3e-09 38.4 0.0 25 5.4 0.0 9.2 10 0 0 10 10 9 0 HMG (high mobility group) box Abhydrolase_8 PF06259.12 ORX60235.1 - 1.9e-07 30.9 81.1 0.49 10.0 0.5 13.4 11 2 1 13 13 13 8 Alpha/beta hydrolase Aldedh PF00171.22 ORX60235.1 - 3.3e-06 25.9 31.1 5.5 5.4 0.0 11.3 13 0 0 13 13 13 5 Aldehyde dehydrogenase family DUF4279 PF14106.6 ORX60235.1 - 0.00013 22.2 0.1 27 5.0 0.0 7.7 13 0 0 13 13 8 0 Domain of unknown function (DUF4279) WXG100 PF06013.12 ORX60235.1 - 0.00013 22.1 49.1 1.9 8.8 0.1 14.5 16 1 0 16 16 15 2 Proteins of 100 residues with WXG GIT_CC PF16559.5 ORX60235.1 - 0.00029 20.7 18.5 70 3.4 0.0 10.5 11 0 0 11 11 11 0 GIT coiled-coil Rho guanine nucleotide exchange factor SpoIIID PF12116.8 ORX60235.1 - 0.0007 19.6 20.9 73 3.6 0.0 11.8 13 0 0 13 13 13 0 Stage III sporulation protein D ApoLp-III PF07464.11 ORX60235.1 - 0.0015 18.7 80.1 0.059 13.5 1.2 14.8 5 3 11 17 17 17 4 Apolipophorin-III precursor (apoLp-III) VHS PF00790.19 ORX60235.1 - 0.0051 16.7 0.2 0.037 13.9 0.2 2.6 1 0 0 1 1 1 1 VHS domain Jnk-SapK_ap_N PF09744.9 ORX60235.1 - 0.011 16.0 0.9 0.047 13.9 0.2 2.6 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF1759 PF03564.15 ORX60235.1 - 0.041 13.8 12.6 81 3.1 0.0 9.8 13 0 0 13 13 12 0 Protein of unknown function (DUF1759) Glutenin_hmw PF03157.13 ORX60235.1 - 0.12 10.8 2.9 0.4 9.0 0.1 3.3 3 0 0 3 3 3 0 High molecular weight glutenin subunit Lar_restr_allev PF14354.6 ORX60235.1 - 0.14 12.6 1.1 0.32 11.4 1.1 1.5 1 0 0 1 1 1 0 Restriction alleviation protein Lar Focal_AT PF03623.13 ORX60235.1 - 0.42 10.6 43.9 12 5.9 0.1 12.3 2 2 10 13 13 13 0 Focal adhesion targeting region FlgN PF05130.12 ORX60235.1 - 1.2 9.7 6.7 7.2 7.1 1.4 5.2 6 0 0 6 6 5 0 FlgN protein Homeodomain PF00046.29 ORX60236.1 - 3.1e-18 65.4 3.9 5.1e-18 64.7 3.9 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX60236.1 - 0.028 14.3 0.7 0.058 13.3 0.3 1.7 2 0 0 2 2 2 0 Homeobox KN domain CBP4 PF07960.11 ORX60237.1 - 7.6e-13 48.4 0.0 8.5e-13 48.3 0.0 1.0 1 0 0 1 1 1 1 CBP4 OSTbeta PF15048.6 ORX60237.1 - 0.047 13.8 0.1 0.055 13.6 0.1 1.0 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein SCFA_trans PF02667.14 ORX60237.1 - 0.2 10.6 0.0 0.23 10.4 0.0 1.0 1 0 0 1 1 1 0 Short chain fatty acid transporter DUF1682 PF07946.14 ORX60238.1 - 3.4e-60 203.9 1.0 3.9e-60 203.8 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) Cytochrom_NNT PF03264.14 ORX60238.1 - 1.1 8.9 3.8 1.6 8.4 3.8 1.2 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region ATP-grasp_2 PF08442.10 ORX60239.1 - 1.4e-77 259.9 0.1 2.2e-77 259.2 0.1 1.3 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 ORX60239.1 - 4.2e-24 85.1 0.9 8.1e-24 84.2 0.9 1.5 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ORX60239.1 - 5.3e-09 35.8 0.1 9.4e-09 35.0 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 ORX60239.1 - 0.00082 19.2 0.9 0.031 14.0 0.0 2.8 3 0 0 3 3 3 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain His_Phos_1 PF00300.22 ORX60240.1 - 0.51 10.0 5.8 0.11 12.1 0.4 2.2 2 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) BUD22 PF09073.10 ORX60241.1 - 0.19 11.0 27.5 0.26 10.6 27.5 1.1 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 ORX60241.1 - 0.45 9.4 2.2 0.84 8.5 2.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Mpp10 PF04006.12 ORX60241.1 - 0.98 7.8 20.9 1.7 7.0 20.9 1.3 1 0 0 1 1 1 0 Mpp10 protein DUF3246 PF11596.8 ORX60241.1 - 4.2 6.7 12.0 5.3 6.4 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Nop14 PF04147.12 ORX60241.1 - 4.2 5.4 33.2 7 4.7 33.2 1.3 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 ORX60241.1 - 9.3 5.5 22.6 14 4.9 22.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ORX60242.1 - 0.0068 14.7 35.9 0.0095 14.2 35.9 1.2 1 0 0 1 1 1 1 Nop14-like family CDC27 PF09507.10 ORX60242.1 - 1 8.7 30.4 1.3 8.3 30.4 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 ADH_zinc_N PF00107.26 ORX60243.1 - 3.3e-25 88.5 0.3 5.9e-25 87.7 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX60243.1 - 3.8e-15 57.1 0.1 7.3e-15 56.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX60243.1 - 4.4e-09 36.2 0.0 3e-08 33.5 0.0 2.3 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ORX60243.1 - 0.024 14.5 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase TrkA_N PF02254.18 ORX60243.1 - 0.07 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Ribosomal_L11 PF00298.19 ORX60244.1 - 1.3e-18 67.2 0.1 2e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 ORX60244.1 - 5.7e-13 48.5 0.0 9.3e-13 47.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Nop PF01798.18 ORX60246.1 - 3.6e-89 298.2 0.0 6.1e-89 297.4 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 ORX60246.1 - 4.8e-22 78.1 0.9 4.8e-22 78.1 0.9 2.5 3 0 0 3 3 3 1 NOP5NT (NUC127) domain Med19 PF10278.9 ORX60246.1 - 0.013 15.5 16.1 0.023 14.7 16.1 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 ETRAMP PF09716.10 ORX60246.1 - 1.4 9.0 7.1 3.7 7.7 7.1 1.8 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Cytomega_UL84 PF06284.11 ORX60246.1 - 2.2 6.6 12.0 3.3 6.1 12.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RNA_polI_A34 PF08208.11 ORX60246.1 - 3.5 7.7 30.0 6.1 6.9 30.0 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 tRNA_lig_CPD PF08302.11 ORX60246.1 - 4.1 6.8 10.8 6.6 6.1 10.8 1.3 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain LsmAD PF06741.13 ORX60247.1 - 3.6e-26 91.5 0.1 3.6e-26 91.5 0.1 3.2 3 0 0 3 3 3 1 LsmAD domain SM-ATX PF14438.6 ORX60247.1 - 3.1e-18 65.7 0.0 5.9e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 ORX60247.1 - 0.05 13.3 0.1 0.094 12.4 0.1 1.4 1 0 0 1 1 1 0 LSM domain SNAD3 PF18749.1 ORX60247.1 - 0.056 12.6 0.1 0.09 11.9 0.1 1.2 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 3 PAM2 PF07145.15 ORX60247.1 - 3.1 7.7 8.7 4.5 7.2 0.8 2.8 2 0 0 2 2 2 0 Ataxin-2 C-terminal region DUF2340 PF10209.9 ORX60248.1 - 7.4e-51 171.6 1.4 8.6e-51 171.4 1.4 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) Blt1 PF12754.7 ORX60248.1 - 0.07 13.4 0.0 0.085 13.2 0.0 1.1 1 0 0 1 1 1 0 Blt1 N-terminal domain Mhr1 PF12829.7 ORX60249.1 - 1.9e-11 43.9 0.1 3.1e-11 43.2 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination Cmc1 PF08583.10 ORX60250.1 - 0.00015 21.8 4.2 0.00025 21.0 4.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like LigB PF02900.18 ORX60251.1 - 1.5e-37 129.2 0.1 1.8e-37 128.9 0.1 1.0 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Ribosomal_S9 PF00380.19 ORX60252.1 - 1.2e-30 106.5 0.2 1.3e-30 106.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DUF2102 PF09875.9 ORX60252.1 - 0.079 12.7 0.1 0.12 12.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2102) Ribosomal_L27A PF00828.19 ORX60253.1 - 2.1e-21 76.9 0.4 2.5e-21 76.7 0.2 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Zip PF02535.22 ORX60254.1 - 1.1 8.4 14.6 1.4 8.1 14.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter UDPGT PF00201.18 ORX60255.1 - 1.4e-24 86.8 2.3 6.3e-24 84.6 0.2 2.6 2 1 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 ORX60255.1 - 9.3e-05 22.5 0.0 0.00016 21.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 ORX60255.1 - 0.061 13.3 0.0 0.22 11.5 0.0 1.9 1 1 0 1 1 1 0 Glycosyltransferase Family 4 Putative_PNPOx PF01243.20 ORX60255.1 - 0.076 13.2 0.0 4.4 7.6 0.0 2.5 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase bZIP_2 PF07716.15 ORX60256.1 - 1.9e-13 50.3 8.3 2.7e-13 49.8 8.3 1.2 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX60256.1 - 0.00014 21.9 8.4 0.00024 21.1 8.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor XhlA PF10779.9 ORX60256.1 - 0.0099 16.1 1.3 0.015 15.5 1.3 1.2 1 0 0 1 1 1 1 Haemolysin XhlA Jnk-SapK_ap_N PF09744.9 ORX60256.1 - 0.13 12.4 4.6 0.18 12.0 4.6 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Bromodomain PF00439.25 ORX60257.1 - 5.7e-17 61.6 1.1 1.5e-16 60.2 1.1 1.8 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 ORX60257.1 - 1.2e-11 44.5 0.4 8.6e-11 41.7 0.1 2.5 3 0 0 3 3 3 1 Bromodomain associated Bromo_TP_like PF17027.5 ORX60257.1 - 0.056 13.6 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Histone-fold protein DUF3437 PF11919.8 ORX60257.1 - 0.089 12.7 1.1 1.1 9.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Nop PF01798.18 ORX60259.1 - 1e-70 237.8 0.0 1.6e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ORX60259.1 - 4.9e-39 134.0 1.9 4.9e-39 134.0 1.9 1.9 2 0 0 2 2 2 1 Prp31 C terminal domain Lipase PF00151.19 ORX60259.1 - 0.082 12.2 0.3 0.31 10.3 0.1 1.9 1 1 1 2 2 2 0 Lipase SpoIIIAH PF12685.7 ORX60259.1 - 2.1 8.1 7.8 3.9 7.3 7.8 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Sec7 PF01369.20 ORX60260.1 - 7.1e-44 149.7 0.0 6.2e-43 146.6 0.0 2.1 1 1 0 1 1 1 1 Sec7 domain PH PF00169.29 ORX60260.1 - 0.00053 20.5 0.0 0.38 11.3 0.0 2.7 2 0 0 2 2 2 2 PH domain PH_10 PF15411.6 ORX60260.1 - 0.011 16.0 0.0 0.033 14.5 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain PH_13 PF16652.5 ORX60260.1 - 0.062 13.1 0.1 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain IQ_SEC7_PH PF16453.5 ORX60260.1 - 0.091 12.7 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 PH domain Arm PF00514.23 ORX60261.1 - 3.6e-89 290.4 14.9 3.3e-13 49.2 0.1 8.5 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ORX60261.1 - 6.8e-26 90.3 0.3 3.6e-08 33.7 0.0 6.1 5 1 1 6 6 6 4 HEAT-like repeat Arm_3 PF16186.5 ORX60261.1 - 3.2e-21 74.6 0.8 4.4e-20 71.0 2.5 2.0 2 0 0 2 2 2 1 Atypical Arm repeat IBB PF01749.20 ORX60261.1 - 6e-20 71.5 7.4 1.7e-19 70.0 7.0 2.0 2 0 0 2 2 2 1 Importin beta binding domain HEAT_2 PF13646.6 ORX60261.1 - 1.8e-16 60.3 0.0 0.00015 22.0 0.0 5.5 1 1 5 6 6 6 5 HEAT repeats HEAT PF02985.22 ORX60261.1 - 2.8e-16 58.2 0.3 0.0044 17.2 0.0 6.9 7 0 0 7 7 6 2 HEAT repeat Arm_2 PF04826.13 ORX60261.1 - 4.5e-06 26.3 0.3 0.076 12.5 0.1 4.2 2 1 2 4 4 4 1 Armadillo-like RICTOR_V PF14668.6 ORX60261.1 - 0.0001 22.4 2.7 0.84 9.9 0.0 4.5 4 1 1 5 5 5 2 Rapamycin-insensitive companion of mTOR, domain 5 Atx10homo_assoc PF09759.9 ORX60261.1 - 0.0031 17.5 0.3 5.9 7.0 0.0 3.3 2 1 2 4 4 4 2 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 ORX60261.1 - 0.0083 16.2 0.2 2.2 8.4 0.0 4.0 3 2 3 6 6 6 1 V-ATPase subunit H CTNNBL PF08216.11 ORX60261.1 - 0.014 15.5 0.4 3.5 7.9 0.0 3.9 5 0 0 5 5 4 0 Catenin-beta-like, Arm-motif containing nuclear HEAT_PBS PF03130.16 ORX60261.1 - 0.08 13.7 0.0 6.4 7.8 0.0 3.3 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat ERCC4 PF02732.15 ORX60262.1 - 8.7e-24 84.5 0.2 2.6e-23 83.0 0.0 1.9 2 0 0 2 2 2 1 ERCC4 domain HetR_C PF18460.1 ORX60262.1 - 0.11 12.4 1.4 14 5.7 0.1 3.4 3 0 0 3 3 3 0 Heterocyst differentiation regulator C-terminal Hood domain G-gamma PF00631.22 ORX60263.1 - 1.7e-16 60.0 0.0 2e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 GGL domain Myb_CC_LHEQLE PF14379.6 ORX60263.1 - 0.045 13.5 1.4 0.063 13.0 1.4 1.3 1 0 0 1 1 1 0 MYB-CC type transfactor, LHEQLE motif HPS3_N PF14761.6 ORX60263.1 - 0.092 12.3 0.1 0.11 12.1 0.1 1.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 P3A PF08727.11 ORX60263.1 - 0.1 12.0 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Poliovirus 3A protein like EF-hand_6 PF13405.6 ORX60264.1 - 1.3e-24 84.0 6.4 1.4e-06 27.7 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_1 PF00036.32 ORX60264.1 - 4.1e-24 82.3 7.5 7.1e-06 25.2 0.0 6.0 5 2 1 6 6 6 4 EF hand EF-hand_7 PF13499.6 ORX60264.1 - 2.6e-23 82.3 1.2 7.5e-09 35.9 0.0 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ORX60264.1 - 8.9e-19 67.1 4.9 2.6e-10 40.0 0.0 4.6 3 2 2 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 ORX60264.1 - 1.2e-18 65.7 5.9 3.6e-05 23.1 0.0 4.7 5 0 0 5 5 5 4 EF hand EF-hand_9 PF14658.6 ORX60264.1 - 4.3e-05 23.8 0.1 0.48 10.8 0.0 3.2 3 1 0 3 3 3 2 EF-hand domain DUF5640 PF18692.1 ORX60264.1 - 0.0019 18.2 0.7 0.0066 16.4 0.2 2.1 1 1 1 2 2 2 1 Family of unknown function (DUF5640) Caleosin PF05042.13 ORX60264.1 - 0.018 15.0 2.7 0.068 13.1 0.5 2.5 1 1 1 3 3 3 0 Caleosin related protein EF-hand_4 PF12763.7 ORX60264.1 - 0.093 12.7 2.3 0.093 12.7 0.3 2.0 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand zf-C2H2_2 PF12756.7 ORX60265.1 - 0.00035 20.9 7.3 0.00049 20.4 5.0 2.3 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ORX60265.1 - 0.00069 20.3 1.3 0.3 11.8 0.1 2.5 1 1 1 2 2 2 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_4 PF13894.6 ORX60265.1 - 0.00071 20.2 10.8 0.068 14.0 0.2 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2HE PF16278.5 ORX60265.1 - 0.0022 18.4 4.1 0.019 15.4 0.4 2.8 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2 PF00096.26 ORX60265.1 - 0.0038 17.6 5.9 0.077 13.5 0.9 3.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF629 PF04780.12 ORX60265.1 - 0.024 13.2 1.2 0.084 11.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_6 PF13912.6 ORX60265.1 - 0.053 13.5 4.8 0.15 12.1 0.6 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX60265.1 - 0.27 11.5 0.4 0.27 11.5 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_9 PF16293.5 ORX60265.1 - 1 9.3 7.2 1.7 8.5 0.1 3.1 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF3958 PF13125.6 ORX60266.1 - 0.023 14.9 6.8 0.035 14.3 6.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3958) CENP-K PF11802.8 ORX60266.1 - 0.033 13.8 0.6 0.038 13.6 0.6 1.1 1 0 0 1 1 1 0 Centromere-associated protein K SUIM_assoc PF16619.5 ORX60266.1 - 9.4 6.4 9.1 3.5 7.8 4.8 2.6 1 1 1 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 OrfB_Zn_ribbon PF07282.11 ORX60267.1 - 4.7e-10 39.2 0.4 8.5e-10 38.4 0.4 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX60267.1 - 0.22 11.6 1.9 0.4 10.8 1.9 1.4 1 0 0 1 1 1 0 Double zinc ribbon Metallophos PF00149.28 ORX60268.1 - 4.8e-14 53.3 0.4 7.5e-14 52.7 0.4 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX60268.1 - 6.5e-06 26.4 0.0 1.4e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain FHA PF00498.26 ORX60269.1 - 3.2e-17 62.6 0.1 5.4e-17 61.9 0.1 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ORX60269.1 - 9.2e-11 41.3 6.6 9.2e-11 41.3 6.6 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX60269.1 - 4e-08 33.5 9.2 4e-08 33.5 9.2 1.7 2 0 0 2 2 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 ORX60269.1 - 0.00049 20.4 0.0 0.001 19.3 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4 PF00097.25 ORX60269.1 - 0.0012 18.6 8.9 0.0012 18.6 8.9 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX60269.1 - 0.0038 17.0 10.0 0.0038 17.0 10.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX60269.1 - 0.007 16.3 8.0 0.016 15.1 8.0 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ORX60269.1 - 0.015 15.6 5.7 0.015 15.6 5.7 2.0 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX60269.1 - 0.022 14.8 1.8 0.042 13.9 1.8 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Vps39_2 PF10367.9 ORX60269.1 - 0.064 13.7 0.4 0.15 12.5 0.4 1.6 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 Zn_ribbon_17 PF17120.5 ORX60269.1 - 0.11 12.1 5.8 0.2 11.3 5.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 ORX60269.1 - 0.17 11.8 4.3 0.31 11.0 4.3 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING_UBOX PF13445.6 ORX60269.1 - 0.35 10.9 13.2 0.18 11.9 10.8 1.9 2 0 0 2 2 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX60269.1 - 0.37 10.7 6.7 0.77 9.7 6.7 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Glycos_transf_1 PF00534.20 ORX60270.1 - 1.2e-18 67.2 0.0 2.6e-18 66.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX60270.1 - 7.7e-13 49.0 0.0 1.5e-12 48.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ORX60270.1 - 5.9e-05 23.4 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_25 PF13649.6 ORX60271.1 - 1.7e-09 38.3 0.0 4.1e-09 37.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX60271.1 - 1.5e-08 35.1 0.0 4.3e-08 33.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX60271.1 - 3.6e-08 33.4 0.0 5.2e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX60271.1 - 4.9e-06 26.4 0.0 0.013 15.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_4 PF02390.17 ORX60271.1 - 0.0056 16.2 0.0 0.33 10.4 0.0 2.4 2 1 0 2 2 2 1 Putative methyltransferase Methyltransf_12 PF08242.12 ORX60271.1 - 0.008 16.9 0.0 0.016 15.9 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_29 PF03141.16 ORX60271.1 - 0.026 13.1 0.0 0.037 12.6 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MetW PF07021.12 ORX60271.1 - 0.1 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_9 PF08003.11 ORX60271.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Aldedh PF00171.22 ORX60272.1 - 6.9e-97 324.8 0.0 8.6e-97 324.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family MDH PF02315.16 ORX60272.1 - 0.026 14.6 0.0 0.1 12.7 0.0 1.9 1 0 0 1 1 1 0 Methanol dehydrogenase beta subunit Myb_DNA-binding PF00249.31 ORX60273.1 - 1.5e-40 137.1 12.2 2.2e-13 50.1 0.5 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX60273.1 - 2.4e-33 114.1 8.2 2.2e-14 53.4 0.7 4.1 2 1 2 4 4 4 3 Myb-like DNA-binding domain zf-C2H2 PF00096.26 ORX60273.1 - 6.6e-05 23.1 15.8 0.11 13.0 1.7 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_aberr PF17017.5 ORX60273.1 - 8e-05 22.9 8.6 0.12 12.5 0.2 3.1 2 1 1 3 3 3 2 Aberrant zinc-finger FOXP-CC PF16159.5 ORX60273.1 - 0.00061 20.4 9.7 0.26 11.9 1.5 4.0 3 1 1 4 4 4 1 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 ORX60273.1 - 0.0014 19.3 19.3 0.52 11.3 2.1 4.5 5 0 0 5 5 3 3 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX60273.1 - 0.0044 17.3 4.9 0.33 11.3 0.1 3.1 3 0 0 3 3 3 2 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 ORX60273.1 - 0.015 15.7 4.7 0.015 15.7 4.7 3.3 3 0 0 3 3 3 0 Zinc-finger double domain SANT_DAMP1_like PF16282.5 ORX60273.1 - 0.022 15.0 1.4 5 7.4 0.4 2.7 2 1 1 3 3 3 0 SANT/Myb-like domain of DAMP1 Rap1_C PF11626.8 ORX60273.1 - 0.029 14.5 5.8 0.06 13.4 0.6 2.9 2 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-bind_7 PF15963.5 ORX60273.1 - 0.46 10.4 4.4 10 6.1 0.4 3.2 2 1 1 3 3 3 0 Myb DNA-binding like zf-C2H2_jaz PF12171.8 ORX60273.1 - 0.54 10.6 7.3 6.5 7.2 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C3HC4_3 PF13920.6 ORX60274.1 - 1.5e-09 37.5 11.5 4.3e-09 36.1 11.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) ERG4_ERG24 PF01222.17 ORX60274.1 - 0.12 11.1 0.0 0.19 10.4 0.0 1.1 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family Cript PF10235.9 ORX60274.1 - 1.2 9.8 9.8 3.4 8.3 9.4 2.0 1 1 0 1 1 1 0 Microtubule-associated protein CRIPT BRO1 PF03097.18 ORX60275.1 - 4.1e-20 71.9 0.0 4.5e-20 71.8 0.0 1.0 1 0 0 1 1 1 1 BRO1-like domain XTBD PF11952.8 ORX60275.1 - 0.051 13.3 0.0 0.074 12.8 0.0 1.2 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD ALIX_LYPXL_bnd PF13949.6 ORX60276.1 - 4.4e-65 219.9 10.5 7.4e-65 219.2 10.5 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV BRO1 PF03097.18 ORX60276.1 - 1.1e-64 218.7 0.2 1.1e-64 218.7 0.2 2.2 3 0 0 3 3 3 1 BRO1-like domain SepSecS PF05889.13 ORX60276.1 - 0.16 10.6 0.2 0.43 9.2 0.1 1.7 1 1 0 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Septin PF00735.18 ORX60277.1 - 1.1e-112 376.0 0.8 1.6e-112 375.4 0.8 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ORX60277.1 - 1.9e-08 34.4 0.0 4.1e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX60277.1 - 2e-08 34.4 0.6 4.4e-07 29.9 0.2 2.6 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ORX60277.1 - 2e-07 30.7 3.5 1.5e-05 24.6 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 ORX60277.1 - 2.5e-05 24.5 0.2 6.1e-05 23.2 0.2 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ORX60277.1 - 0.0013 19.0 0.0 0.0052 17.2 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 ORX60277.1 - 0.0028 18.1 0.5 0.013 15.8 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain Ras PF00071.22 ORX60277.1 - 0.003 17.2 0.1 0.0085 15.7 0.1 1.8 1 0 0 1 1 1 1 Ras family Sigma54_activat PF00158.26 ORX60277.1 - 0.0031 17.2 0.1 0.0063 16.2 0.1 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_22 PF13401.6 ORX60277.1 - 0.0035 17.6 1.5 0.0061 16.8 0.1 2.1 2 1 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ORX60277.1 - 0.0048 16.3 0.1 0.012 15.0 0.1 1.6 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_7 PF12775.7 ORX60277.1 - 0.0063 16.0 0.2 0.012 15.2 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AIG1 PF04548.16 ORX60277.1 - 0.0066 15.8 0.2 0.016 14.6 0.2 1.6 1 0 0 1 1 1 1 AIG1 family AAA_33 PF13671.6 ORX60277.1 - 0.0096 16.1 0.9 0.046 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain IIGP PF05049.13 ORX60277.1 - 0.012 14.7 0.9 0.052 12.6 0.2 2.0 1 1 1 2 2 2 0 Interferon-inducible GTPase (IIGP) ATP_bind_1 PF03029.17 ORX60277.1 - 0.018 14.8 1.5 1.3 8.7 0.1 3.4 3 1 1 4 4 4 0 Conserved hypothetical ATP binding protein Dynamin_N PF00350.23 ORX60277.1 - 0.027 14.5 7.8 0.79 9.8 0.1 3.3 2 1 1 3 3 3 0 Dynamin family Pox_A32 PF04665.12 ORX60277.1 - 0.031 13.7 0.3 0.077 12.4 0.0 1.7 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_25 PF13481.6 ORX60277.1 - 0.038 13.6 0.0 0.097 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX60277.1 - 0.043 13.6 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 ORX60277.1 - 0.054 14.0 1.8 0.071 13.6 0.0 2.0 2 1 0 2 2 2 0 ABC transporter NTPase_1 PF03266.15 ORX60277.1 - 0.061 13.2 1.0 0.56 10.1 0.3 2.4 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 ORX60277.1 - 0.061 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 ORX60277.1 - 0.075 13.5 0.0 0.075 13.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ORX60277.1 - 0.086 12.6 1.2 2.1 8.1 0.4 2.6 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 ORX60277.1 - 0.098 12.4 4.9 0.096 12.4 1.4 2.5 2 1 1 3 3 3 0 AAA domain Gtr1_RagA PF04670.12 ORX60277.1 - 0.21 10.9 1.4 0.29 10.5 0.0 2.0 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Mei5 PF10376.9 ORX60277.1 - 0.4 10.5 9.0 0.28 11.0 4.3 2.2 2 0 0 2 2 2 0 Double-strand recombination repair protein Glycos_transf_1 PF00534.20 ORX60278.1 - 2.4e-28 98.8 0.0 2.2e-17 63.1 0.0 2.5 1 1 1 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX60278.1 - 9.7e-15 55.0 0.1 1.5e-14 54.3 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 ORX60278.1 - 4.2e-12 46.6 0.0 1e-11 45.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 ORX60278.1 - 1.9e-06 28.4 0.0 3.6e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 ORX60278.1 - 0.001 19.1 3.1 1.5 8.8 0.1 3.1 1 1 1 2 2 2 2 ALG11 mannosyltransferase N-terminus LSM PF01423.22 ORX60279.1 - 7.5e-17 60.8 0.2 8.7e-17 60.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain TFIIE_alpha PF02002.17 ORX60280.1 - 7.7e-13 48.2 0.9 2.1e-12 46.8 0.2 2.1 2 0 0 2 2 2 1 TFIIE alpha subunit zf-SNAP50_C PF12251.8 ORX60280.1 - 0.011 15.4 1.0 0.022 14.4 1.0 1.4 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal zf-C2H2_6 PF13912.6 ORX60280.1 - 0.017 15.1 4.9 0.023 14.7 0.4 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger Phytoreo_S7 PF07236.11 ORX60280.1 - 0.022 13.1 0.0 0.033 12.6 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus S7 protein SVIP PF15811.5 ORX60280.1 - 0.035 14.5 2.5 0.16 12.5 0.5 2.7 2 0 0 2 2 2 0 Small VCP/p97-interacting protein IR1-M PF12185.8 ORX60280.1 - 0.059 13.3 0.0 0.059 13.3 0.0 2.5 3 0 0 3 3 1 0 Nup358/RanBP2 E3 ligase domain zf-CHY PF05495.12 ORX60280.1 - 0.061 13.8 1.1 0.12 12.9 1.1 1.5 1 0 0 1 1 1 0 CHY zinc finger zf_UBZ PF18439.1 ORX60280.1 - 0.089 12.4 1.6 7.6 6.2 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cdc6_C PF09079.11 ORX60280.1 - 0.091 12.7 0.1 0.26 11.3 0.1 1.7 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain ADK_lid PF05191.14 ORX60280.1 - 0.15 12.0 0.1 0.38 10.8 0.1 1.7 1 0 0 1 1 1 0 Adenylate kinase, active site lid B-block_TFIIIC PF04182.12 ORX60280.1 - 0.17 12.1 0.0 0.32 11.2 0.0 1.5 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Ribosomal_S26e PF01283.19 ORX60281.1 - 2.4e-53 179.1 9.6 2.8e-53 178.9 9.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e LRV PF01816.17 ORX60281.1 - 1.6 9.3 6.3 3.3 8.3 6.3 1.5 1 0 0 1 1 1 0 Leucine rich repeat variant Arv1 PF04161.13 ORX60282.1 - 8e-54 183.0 13.9 9.6e-54 182.7 13.9 1.1 1 0 0 1 1 1 1 Arv1-like family ICL PF00463.21 ORX60283.1 - 1.1e-252 839.2 2.8 1.3e-252 839.0 2.8 1.0 1 0 0 1 1 1 1 Isocitrate lyase family Arg_repressor_C PF02863.18 ORX60283.1 - 0.13 12.1 0.1 0.34 10.8 0.1 1.7 1 0 0 1 1 1 0 Arginine repressor, C-terminal domain Aldo_ket_red PF00248.21 ORX60284.1 - 1.2e-10 41.1 0.0 1.4e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family SNF2_N PF00176.23 ORX60285.1 - 2.2e-65 220.7 1.3 4.3e-65 219.7 1.3 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain DBINO PF13892.6 ORX60285.1 - 1.3e-47 161.5 19.7 1.3e-47 161.5 19.7 3.1 3 0 0 3 3 3 1 DNA-binding domain Helicase_C PF00271.31 ORX60285.1 - 8.2e-18 64.8 1.0 2.8e-17 63.1 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX60285.1 - 8.8e-06 25.8 0.0 3.7e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ORX60285.1 - 0.0032 16.7 0.0 0.0032 16.7 0.0 2.5 3 1 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 baeRF_family12 PF18856.1 ORX60285.1 - 0.14 12.8 0.2 0.14 12.8 0.2 4.0 4 0 0 4 4 4 0 Bacterial archaeo-eukaryotic release factor family 12 DUF1643 PF07799.12 ORX60285.1 - 1.1 9.5 4.6 4.5 7.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) SHS2_Rpb7-N PF03876.17 ORX60286.1 - 9.1e-17 61.2 0.0 1.8e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ORX60286.1 - 2.6e-10 40.5 0.0 5.6e-10 39.4 0.0 1.5 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 ORX60286.1 - 0.014 15.6 0.0 0.021 15.0 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 RINGv PF12906.7 ORX60287.1 - 2.5e-07 30.7 9.4 5e-07 29.7 9.4 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 ORX60287.1 - 0.0022 18.3 7.7 0.0044 17.3 7.7 1.5 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 ORX60287.1 - 0.011 15.9 5.3 0.023 14.9 5.3 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 ORX60287.1 - 0.03 14.1 5.6 0.055 13.3 5.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zinc_ribbon_5 PF13719.6 ORX60287.1 - 0.073 12.8 1.0 0.26 11.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.12 ORX60287.1 - 0.095 12.7 0.2 0.25 11.3 0.2 1.7 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Spc7_N PF15402.6 ORX60287.1 - 0.39 8.9 4.1 0.58 8.4 4.1 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 zf-C3HC4 PF00097.25 ORX60287.1 - 2.5 8.1 6.7 4.3 7.3 6.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 ORX60287.1 - 7.1 6.6 7.3 12 5.8 7.3 1.4 1 0 0 1 1 1 0 PHD-finger Clathrin PF00637.20 ORX60289.1 - 1e-18 67.6 16.4 1.4e-17 63.9 5.1 3.7 2 2 1 3 3 3 2 Region in Clathrin and VPS Vps8 PF12816.7 ORX60289.1 - 0.051 13.1 3.1 0.17 11.4 0.6 2.4 2 0 0 2 2 2 0 Golgi CORVET complex core vacuolar protein 8 DUF5049 PF16468.5 ORX60289.1 - 0.2 11.6 1.6 12 5.8 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5049) COX4 PF02936.14 ORX60290.1 - 1.7e-40 138.3 0.2 2e-40 138.0 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF1281 PF06924.11 ORX60290.1 - 0.11 12.0 0.5 0.41 10.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1281) Trp_oprn_chp PF09534.10 ORX60290.1 - 0.13 12.1 1.9 0.21 11.4 1.8 1.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) HMG_box_2 PF09011.10 ORX60290.1 - 0.69 10.5 5.2 8.1 7.1 0.6 2.9 2 1 1 3 3 3 0 HMG-box domain DUF1289 PF06945.13 ORX60290.1 - 4.6 7.1 5.0 12 5.7 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1289) UCH PF00443.29 ORX60291.1 - 3.4e-50 170.9 0.1 4.2e-50 170.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX60291.1 - 6.5e-13 49.0 0.0 1e-12 48.3 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UNC45-central PF11701.8 ORX60292.1 - 8.8e-26 90.7 3.9 2e-25 89.6 0.6 3.1 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central TPR_1 PF00515.28 ORX60292.1 - 5.4e-05 22.8 0.0 0.00018 21.2 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX60292.1 - 7.6e-05 22.5 0.0 0.00058 19.8 0.0 2.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX60292.1 - 0.00063 19.8 0.0 0.0028 17.7 0.0 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX60292.1 - 0.00076 20.1 4.3 0.0071 17.1 0.2 4.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Arm PF00514.23 ORX60292.1 - 0.00077 19.4 12.0 4.2 7.6 0.1 6.3 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat TPR_6 PF13174.6 ORX60292.1 - 0.0012 19.4 0.1 0.0012 19.4 0.1 3.4 3 0 0 3 3 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 ORX60292.1 - 0.0036 17.4 4.9 0.014 15.5 0.5 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX60292.1 - 0.0082 16.8 2.9 0.011 16.4 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat Arm_3 PF16186.5 ORX60292.1 - 0.035 13.6 0.1 10 5.8 0.0 2.5 2 0 0 2 2 2 0 Atypical Arm repeat TPR_12 PF13424.6 ORX60292.1 - 0.052 13.9 3.4 0.25 11.7 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat HEAT_2 PF13646.6 ORX60292.1 - 0.1 13.0 19.1 1.2 9.6 0.9 6.6 4 3 3 7 7 7 0 HEAT repeats Fis1_TPR_C PF14853.6 ORX60292.1 - 1.2 9.3 5.4 0.13 12.3 0.3 2.1 2 0 0 2 2 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ORX60292.1 - 4.2 7.4 7.1 10 6.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat CK2S PF15011.6 ORX60293.1 - 0.019 14.9 0.3 0.03 14.2 0.3 1.3 1 1 0 1 1 1 0 Casein Kinase 2 substrate TolA_bind_tri PF16331.5 ORX60293.1 - 0.51 10.4 6.3 0.17 12.0 0.6 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation G-alpha PF00503.20 ORX60294.1 - 4.4e-110 368.2 0.2 5.1e-110 368.0 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX60294.1 - 2.7e-15 56.3 0.6 3.7e-10 39.5 0.1 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX60294.1 - 0.00027 20.3 0.2 0.46 9.8 0.0 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX60294.1 - 0.0025 18.0 0.1 0.57 10.4 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX60294.1 - 0.028 14.5 0.0 5.5 7.1 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase SMP_C2CD2L PF18696.1 ORX60294.1 - 0.092 12.6 0.2 1 9.1 0.0 2.2 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain AAA_29 PF13555.6 ORX60294.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Pyrophosphatase PF00719.19 ORX60295.1 - 1.2e-58 197.4 0.7 1.6e-58 197.1 0.7 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Malate_synthase PF01274.22 ORX60296.1 - 1.2e-224 746.4 0.0 1.4e-224 746.2 0.0 1.0 1 0 0 1 1 1 1 Malate synthase Glyco_transf_49 PF13896.6 ORX60297.1 - 4.6e-60 203.7 2.5 1.6e-46 159.2 0.9 2.0 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_tranf_2_4 PF13704.6 ORX60297.1 - 0.072 13.6 0.6 0.072 13.6 0.6 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 2 ABC_membrane PF00664.23 ORX60298.1 - 1.3e-54 185.7 28.5 5.5e-35 121.3 10.5 3.5 4 1 0 4 4 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX60298.1 - 6.5e-53 178.9 0.0 4e-30 105.1 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX60298.1 - 8e-11 41.8 1.6 3.8e-05 23.2 0.2 4.2 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX60298.1 - 1.8e-07 31.9 0.5 0.0025 18.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain AAA_29 PF13555.6 ORX60298.1 - 4.2e-07 29.6 0.2 0.031 14.0 0.0 2.9 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 ORX60298.1 - 4.9e-07 29.1 0.2 0.0028 16.8 0.1 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_22 PF13401.6 ORX60298.1 - 3.4e-06 27.4 2.5 0.017 15.4 0.1 3.3 2 1 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ORX60298.1 - 4e-06 26.5 0.1 0.018 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 ORX60298.1 - 5.3e-05 23.4 0.3 0.16 12.0 0.0 2.5 2 0 0 2 2 2 2 Helicase HerA, central domain AAA_16 PF13191.6 ORX60298.1 - 5.9e-05 23.5 1.0 0.57 10.6 0.1 3.1 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX60298.1 - 7.6e-05 22.7 0.0 0.1 12.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase FtsK_SpoIIIE PF01580.18 ORX60298.1 - 0.00027 20.4 0.0 0.4 10.0 0.0 2.3 2 0 0 2 2 2 2 FtsK/SpoIIIE family AAA_30 PF13604.6 ORX60298.1 - 0.00085 19.1 0.9 0.5 10.1 0.1 3.7 4 0 0 4 4 4 1 AAA domain Pox_A32 PF04665.12 ORX60298.1 - 0.0011 18.5 0.4 0.45 9.9 0.0 2.5 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_33 PF13671.6 ORX60298.1 - 0.0012 19.0 0.0 0.069 13.3 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX60298.1 - 0.0014 19.2 0.6 2.6 8.6 0.5 2.8 2 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 ORX60298.1 - 0.0014 18.4 0.2 0.17 11.6 0.0 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 ORX60298.1 - 0.0015 18.6 0.1 0.64 10.1 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 ORX60298.1 - 0.0018 18.2 0.9 5 6.8 0.1 3.8 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 ORX60298.1 - 0.002 17.7 1.3 1.4 8.4 0.0 2.6 3 0 0 3 3 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 ORX60298.1 - 0.0027 17.5 0.2 1.1 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ORX60298.1 - 0.0034 16.7 0.0 2 7.6 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin ATP_bind_1 PF03029.17 ORX60298.1 - 0.005 16.6 1.5 1.9 8.2 0.1 2.6 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein DEAD PF00270.29 ORX60298.1 - 0.0051 16.6 0.3 1.7 8.4 0.0 3.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase IstB_IS21 PF01695.17 ORX60298.1 - 0.0057 16.4 0.2 6.7 6.4 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein cobW PF02492.19 ORX60298.1 - 0.0058 16.2 1.3 0.023 14.3 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Dynamin_N PF00350.23 ORX60298.1 - 0.013 15.5 0.1 0.94 9.5 0.0 3.0 2 0 0 2 2 2 0 Dynamin family NACHT PF05729.12 ORX60298.1 - 0.016 15.2 0.5 0.66 9.9 0.1 2.6 2 0 0 2 2 2 0 NACHT domain Roc PF08477.13 ORX60298.1 - 0.018 15.3 0.3 9.4 6.5 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NB-ARC PF00931.22 ORX60298.1 - 0.02 14.1 1.7 3.4 6.8 0.0 3.3 4 0 0 4 4 4 0 NB-ARC domain AAA PF00004.29 ORX60298.1 - 0.024 15.0 0.8 8.8 6.8 0.1 3.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ORX60298.1 - 0.026 14.8 0.5 0.61 10.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ORX60298.1 - 0.032 13.9 0.6 6.4 6.4 0.0 2.8 3 0 0 3 3 3 0 AAA ATPase domain ResIII PF04851.15 ORX60298.1 - 0.032 14.2 0.0 12 5.9 0.0 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit SbcCD_C PF13558.6 ORX60298.1 - 0.034 14.4 0.1 11 6.4 0.0 3.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 ORX60298.1 - 0.034 13.8 0.6 3.1 7.4 0.3 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 ORX60298.1 - 0.043 13.9 0.2 6.5 6.8 0.0 3.2 3 0 0 3 3 3 0 AAA domain CbiA PF01656.23 ORX60298.1 - 0.054 13.5 0.5 25 5.0 0.1 3.2 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain RNA_helicase PF00910.22 ORX60298.1 - 0.057 13.8 0.1 20 5.6 0.0 2.8 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 ORX60298.1 - 0.095 12.6 0.9 14 5.6 0.1 2.6 2 0 0 2 2 2 0 NTPase Septin PF00735.18 ORX60298.1 - 0.11 11.8 0.0 6.7 5.9 0.0 2.3 2 0 0 2 2 2 0 Septin ATPase PF06745.13 ORX60298.1 - 0.11 11.8 0.2 3.6 6.9 0.0 2.3 2 0 0 2 2 2 0 KaiC Kelch_5 PF13854.6 ORX60299.1 - 1.6e-12 47.1 4.1 1.9e-06 27.7 0.0 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ORX60299.1 - 3.5e-12 46.1 5.5 0.0016 18.6 0.1 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ORX60299.1 - 2.7e-11 43.3 6.7 2.1e-07 30.8 0.3 4.4 4 2 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX60299.1 - 4.8e-11 42.1 0.5 7.1e-07 28.7 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ORX60299.1 - 5.1e-09 35.7 0.1 0.0009 19.1 0.0 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ORX60299.1 - 1.6e-07 31.5 9.4 0.0012 19.1 0.1 4.7 5 0 0 5 5 5 2 Galactose oxidase, central domain WD40 PF00400.32 ORX60300.1 - 2.4e-08 34.5 4.4 0.15 13.0 0.2 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 ORX60300.1 - 1.5e-05 24.5 0.4 0.0006 19.2 0.0 2.4 1 1 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 ORX60300.1 - 0.0017 18.6 0.1 3.2 8.1 0.0 3.3 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ORX60300.1 - 0.012 14.4 0.0 0.39 9.4 0.0 2.2 1 1 1 2 2 2 0 Nup133 N terminal like PQQ_3 PF13570.6 ORX60300.1 - 0.075 13.5 0.0 4.7 7.8 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain Scs3p PF10261.9 ORX60301.1 - 3.5e-33 115.1 13.2 6.9e-24 84.7 0.6 2.0 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM PAP2 PF01569.21 ORX60301.1 - 0.076 12.8 5.8 0.094 12.5 5.8 1.1 1 0 0 1 1 1 0 PAP2 superfamily DUF1430 PF07242.11 ORX60301.1 - 2.1 8.6 5.4 16 5.8 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1430) PITH PF06201.13 ORX60302.1 - 1.9e-38 132.1 4.3 3.1e-38 131.4 4.3 1.3 1 0 0 1 1 1 1 PITH domain Thioredoxin PF00085.20 ORX60302.1 - 5.6e-30 103.4 0.3 1.6e-29 101.9 0.3 1.8 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX60302.1 - 1.8e-06 28.4 0.7 4.9e-06 27.0 0.2 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ORX60302.1 - 0.00022 21.5 0.0 0.00065 20.0 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 ORX60302.1 - 0.0013 18.2 0.2 0.0023 17.3 0.2 1.4 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_9 PF14595.6 ORX60302.1 - 0.0043 16.8 0.0 0.0076 16.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 ORX60302.1 - 0.017 14.8 0.1 0.038 13.7 0.1 1.6 1 0 0 1 1 1 0 Redoxin Phosducin PF02114.16 ORX60302.1 - 0.035 13.0 0.0 0.056 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosducin Thioredoxin_7 PF13899.6 ORX60302.1 - 0.041 14.1 0.4 0.13 12.5 0.1 2.0 2 0 0 2 2 2 0 Thioredoxin-like NAM-associated PF14303.6 ORX60303.1 - 0.37 11.5 2.8 0.43 11.3 2.8 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Pkinase PF00069.25 ORX60305.1 - 2.1e-52 178.1 0.0 3e-52 177.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60305.1 - 7.3e-36 123.8 0.0 1e-35 123.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX60305.1 - 1.4e-05 24.0 0.2 2.8e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX60305.1 - 0.036 13.4 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Kinase-like Cyt-b5 PF00173.28 ORX60306.1 - 1.7e-10 40.9 0.3 2.3e-10 40.4 0.3 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 ORX60307.1 - 1.4e-22 80.4 16.2 1.4e-22 80.4 16.2 2.6 2 1 1 3 3 3 2 Fatty acid hydroxylase superfamily TatC PF00902.18 ORX60307.1 - 1.2 8.9 7.7 10 5.9 7.7 2.2 1 1 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DUF1744 PF08490.12 ORX60308.1 - 1.5e-121 405.8 0.1 2.4e-121 405.1 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 ORX60308.1 - 9.1e-81 271.6 1.7 1.4e-80 270.9 1.7 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 ORX60308.1 - 1.9e-13 50.0 0.2 8.9e-12 44.5 0.1 3.0 2 1 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 ORX60308.1 - 6e-09 35.9 0.2 1.4e-08 34.6 0.2 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ORX60308.1 - 1.5e-05 25.0 0.4 5.9e-05 23.1 0.1 2.2 2 0 0 2 2 2 1 RNase_H superfamily GerPC PF10737.9 ORX60308.1 - 0.012 15.6 0.8 5.7 7.0 0.3 2.9 2 0 0 2 2 2 0 Spore germination protein GerPC DUF4379 PF14311.6 ORX60308.1 - 0.34 11.3 2.0 7.4 7.0 0.3 2.9 2 0 0 2 2 2 0 Probable Zinc-ribbon domain zf-C4 PF00105.18 ORX60308.1 - 0.78 10.2 2.4 3.5 8.2 2.4 2.2 1 0 0 1 1 1 0 Zinc finger, C4 type (two domains) zf-CHY PF05495.12 ORX60308.1 - 2.8 8.5 6.2 1.9 9.0 2.4 2.5 2 0 0 2 2 2 0 CHY zinc finger SIR2 PF02146.17 ORX60309.1 - 3.9e-56 189.8 0.0 4.9e-56 189.4 0.0 1.1 1 0 0 1 1 1 1 Sir2 family PP-binding_2 PF14573.6 ORX60309.1 - 0.041 14.1 0.0 0.072 13.3 0.0 1.3 1 0 0 1 1 1 0 Acyl-carrier Med16 PF11635.8 ORX60311.1 - 7.2e-19 67.2 1.6 2.3e-11 42.4 0.0 2.8 1 1 1 2 2 2 2 Mediator complex subunit 16 ANAPC4_WD40 PF12894.7 ORX60311.1 - 0.00015 22.0 0.0 0.023 15.0 0.1 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 ORX60312.1 - 1.2e-70 238.0 0.0 1.5e-70 237.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60312.1 - 4e-33 114.8 0.0 7.2e-33 114.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX60312.1 - 1.3e-06 28.0 0.0 0.0037 16.6 0.0 2.5 1 1 1 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX60312.1 - 0.00046 19.8 0.1 0.0011 18.6 0.1 1.6 1 1 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ORX60312.1 - 0.053 12.5 0.0 0.12 11.3 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 ORX60312.1 - 0.073 13.0 0.1 0.33 10.8 0.0 2.0 2 1 0 3 3 3 0 Phosphotransferase enzyme family zf-C2H2 PF00096.26 ORX60313.1 - 3.5e-08 33.4 6.0 0.00068 20.0 0.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX60313.1 - 1.3e-06 28.7 5.3 0.028 15.3 1.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger INO80_Ies4 PF08193.11 ORX60313.1 - 2e-05 24.7 3.0 2e-05 24.7 3.0 1.6 2 0 0 2 2 2 1 INO80 complex subunit Ies4 FOXP-CC PF16159.5 ORX60313.1 - 0.014 16.0 4.3 1.6 9.4 0.6 2.3 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_3rep PF18868.1 ORX60313.1 - 0.032 14.9 1.0 0.073 13.7 1.0 1.6 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 ORX60313.1 - 0.14 12.4 1.7 0.37 11.1 1.7 1.7 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ORX60313.1 - 0.54 10.6 10.5 3.4 8.1 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding MSA-2c PF12238.8 ORX60313.1 - 1.3 8.9 5.5 2.2 8.2 5.5 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c zf_C2H2_ZHX PF18387.1 ORX60313.1 - 1.6 8.4 6.8 0.35 10.5 2.6 1.9 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain Gti1_Pac2 PF09729.9 ORX60314.1 - 8.1e-53 179.2 10.3 2e-41 142.1 0.0 3.3 2 2 1 3 3 3 2 Gti1/Pac2 family UCH PF00443.29 ORX60315.1 - 3.8e-41 141.3 0.0 8.2e-41 140.2 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP_var PF17807.1 ORX60315.1 - 1.1e-24 86.0 10.5 2.7e-23 81.5 2.0 2.9 2 1 0 2 2 2 2 Variant UBP zinc finger UBA PF00627.31 ORX60315.1 - 5.9e-24 83.6 5.1 6.6e-12 45.1 0.6 2.4 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP PF02148.19 ORX60315.1 - 4.6e-22 78.1 18.3 6.4e-19 68.1 7.1 5.0 5 1 0 5 5 5 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ORX60315.1 - 8.1e-15 55.2 5.8 8.1e-15 55.2 5.8 3.1 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Ion_trans PF00520.31 ORX60316.1 - 7.9e-127 421.5 102.1 2.1e-38 131.9 13.4 4.1 4 0 0 4 4 4 4 Ion transport protein Mito_carr PF00153.27 ORX60317.1 - 6.4e-79 260.0 1.7 5.4e-28 96.8 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein SOG2 PF10428.9 ORX60318.1 - 2.6e-10 40.1 22.7 9.1e-10 38.3 15.9 3.3 1 1 1 3 3 3 2 RAM signalling pathway protein Peptidase_C12 PF01088.21 ORX60319.1 - 9.2e-45 153.0 0.3 1.1e-44 152.8 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Vezatin PF12632.7 ORX60319.1 - 0.052 12.9 0.2 0.083 12.3 0.2 1.2 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes OrfB_Zn_ribbon PF07282.11 ORX60320.1 - 5.4e-10 39.0 0.7 2.1e-09 37.2 0.7 1.9 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX60320.1 - 0.057 13.2 0.0 0.082 12.7 0.0 1.2 1 0 0 1 1 1 0 Restriction endonuclease EcoRII, N-terminal zinc_ribbon_11 PF11682.8 ORX60320.1 - 0.079 13.0 0.3 0.14 12.2 0.0 1.5 2 0 0 2 2 2 0 Probable zinc-ribbon Kelch_4 PF13418.6 ORX60322.1 - 0.0014 18.6 0.3 1 9.4 0.0 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX60322.1 - 0.0017 18.3 0.0 0.54 10.3 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ORX60322.1 - 0.0029 17.9 8.5 0.041 14.2 0.0 4.6 4 1 0 4 4 4 2 Galactose oxidase, central domain CYYR1 PF10873.8 ORX60322.1 - 0.034 14.6 0.0 0.13 12.7 0.0 2.0 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Podoplanin PF05808.11 ORX60322.1 - 0.12 12.4 0.2 0.28 11.3 0.2 1.5 1 0 0 1 1 1 0 Podoplanin Na_sulph_symp PF00939.19 ORX60323.1 - 6.3e-95 319.0 30.4 7.4e-95 318.7 30.4 1.0 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX60323.1 - 3.5e-20 72.4 28.4 1.1e-11 44.4 8.0 2.4 2 1 0 2 2 2 2 Citrate transporter Mannosyl_trans PF05007.13 ORX60324.1 - 4.5e-60 203.7 26.3 6.4e-45 154.0 14.4 2.8 2 1 1 3 3 3 2 Mannosyltransferase (PIG-M) PIG-U PF06728.13 ORX60324.1 - 1.4e-10 40.8 19.9 1.8e-10 40.5 19.9 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 ORX60324.1 - 0.003 17.3 9.0 0.003 17.3 9.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 87 DUF3347 PF11827.8 ORX60325.1 - 0.0031 17.7 0.5 0.0043 17.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3347) AnfO_nitrog PF09582.10 ORX60325.1 - 0.068 12.5 0.5 0.16 11.3 0.2 1.6 1 1 1 2 2 2 0 Iron only nitrogenase protein AnfO (AnfO_nitrog) Myotub-related PF06602.14 ORX60327.1 - 2.1e-150 500.5 0.8 2.5e-150 500.3 0.8 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ORX60327.1 - 0.00026 20.6 0.1 0.00068 19.3 0.1 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ORX60327.1 - 0.00027 20.7 0.3 0.00082 19.2 0.3 1.8 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ORX60327.1 - 0.15 12.0 0.0 0.35 10.8 0.0 1.6 1 0 0 1 1 1 0 Tyrosine phosphatase family Catalase PF00199.19 ORX60328.1 - 8.7e-199 660.4 0.7 1e-198 660.1 0.7 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 ORX60328.1 - 9e-24 83.5 0.1 2.3e-23 82.2 0.1 1.6 1 0 0 1 1 1 1 Catalase-related immune-responsive Pkinase PF00069.25 ORX60329.1 - 7.5e-61 205.8 0.0 9.8e-61 205.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60329.1 - 2.5e-36 125.3 0.0 3.6e-36 124.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX60329.1 - 5.9e-05 22.2 0.0 0.0003 19.8 0.0 1.9 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ORX60329.1 - 0.0012 18.4 0.0 0.003 17.2 0.0 1.6 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ORX60329.1 - 0.0013 18.1 0.0 0.012 15.0 0.0 2.2 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX60329.1 - 0.0097 15.9 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX60329.1 - 0.018 13.8 0.0 0.03 13.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase HHH_4 PF14490.6 ORX60329.1 - 0.018 15.0 0.0 2.4 8.2 0.0 2.6 3 0 0 3 3 3 0 Helix-hairpin-helix containing domain Choline_kinase PF01633.20 ORX60329.1 - 0.12 11.9 0.0 0.31 10.6 0.0 1.5 1 1 0 1 1 1 0 Choline/ethanolamine kinase PTR2 PF00854.21 ORX60330.1 - 3e-93 312.8 8.3 5e-93 312.1 8.3 1.3 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 ORX60330.1 - 1.3e-11 44.0 15.3 3.8e-10 39.2 16.7 2.4 2 1 0 2 2 2 1 Major Facilitator Superfamily DUF2070 PF09843.9 ORX60330.1 - 0.16 10.2 10.3 0.28 9.4 0.4 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) MFS_MOT1 PF16983.5 ORX60330.1 - 2.8 8.4 6.6 0.41 11.1 1.8 2.1 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily PIF1 PF05970.14 ORX60331.1 - 8.7e-12 44.9 0.2 2.7e-10 40.0 0.2 2.4 1 1 0 1 1 1 1 PIF1-like helicase SH3_13 PF18335.1 ORX60331.1 - 0.12 12.2 0.0 0.63 9.9 0.0 2.2 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain PIF1 PF05970.14 ORX60332.1 - 1.4e-22 80.4 0.2 1.9e-22 80.0 0.2 1.1 1 0 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 ORX60332.1 - 2.3e-15 56.8 0.1 3.1e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ORX60332.1 - 9.2e-07 29.3 0.0 1.4e-06 28.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX60332.1 - 1.3e-05 25.5 0.0 2.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ORX60332.1 - 2.5e-05 23.9 0.0 4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ORX60332.1 - 5.5e-05 23.6 0.1 9.8e-05 22.8 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ORX60332.1 - 0.0013 17.8 0.0 0.0021 17.2 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 ORX60332.1 - 0.003 18.0 0.0 0.0053 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 ORX60332.1 - 0.0034 16.7 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 ORX60332.1 - 0.005 17.2 0.1 0.013 15.9 0.0 1.8 2 0 0 2 2 1 1 RNA helicase Mg_chelatase PF01078.21 ORX60332.1 - 0.0052 16.2 0.0 0.0097 15.3 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PhoH PF02562.16 ORX60332.1 - 0.0058 16.1 0.0 0.0096 15.4 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein AAA_29 PF13555.6 ORX60332.1 - 0.02 14.6 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 ORX60332.1 - 0.03 14.3 0.0 0.066 13.2 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit ABC_tran PF00005.27 ORX60332.1 - 0.036 14.6 0.0 0.12 12.9 0.0 1.8 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 ORX60332.1 - 0.036 14.0 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase FtsK_SpoIIIE PF01580.18 ORX60332.1 - 0.038 13.3 0.0 0.061 12.7 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 ORX60332.1 - 0.04 12.8 0.0 0.075 11.9 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 ORX60332.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 ORX60332.1 - 0.077 12.7 0.0 1.7 8.3 0.0 2.2 1 1 0 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.18 ORX60332.1 - 0.1 12.5 0.0 0.27 11.1 0.0 1.6 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ORX60332.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 ORX60332.1 - 0.17 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_10 PF12846.7 ORX60332.1 - 0.18 10.7 0.0 0.28 10.1 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain Sigma54_activat PF00158.26 ORX60332.1 - 0.19 11.4 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Helicase_RecD PF05127.14 ORX60332.1 - 0.2 11.5 0.0 0.53 10.1 0.0 1.7 2 0 0 2 2 1 0 Helicase UvrD-helicase PF00580.21 ORX60332.1 - 0.2 11.1 0.1 0.29 10.6 0.1 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Adeno_IVa2 PF02456.15 ORX60332.1 - 0.2 10.4 0.0 0.3 9.8 0.0 1.1 1 0 0 1 1 1 0 Adenovirus IVa2 protein RdRP PF05183.12 ORX60333.1 - 4.6e-185 616.7 0.0 6.2e-185 616.2 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase SNF2_N PF00176.23 ORX60334.1 - 1e-26 93.5 4.6 1.5e-24 86.4 4.2 2.3 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX60334.1 - 3.1e-14 53.2 0.0 7.1e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ORX60334.1 - 9e-05 21.8 0.1 0.00015 21.1 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ORX60334.1 - 0.0003 20.9 0.0 0.0031 17.5 0.0 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit RTC PF01137.21 ORX60334.1 - 0.013 14.8 0.0 0.025 13.8 0.0 1.6 2 0 0 2 2 2 0 RNA 3'-terminal phosphate cyclase DUF2075 PF09848.9 ORX60334.1 - 0.087 12.0 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 ORX60334.1 - 0.1 12.4 0.0 0.94 9.2 0.0 2.2 1 1 0 1 1 1 0 DEAD/DEAH box helicase Pkinase PF00069.25 ORX60335.1 - 7.5e-65 218.9 0.0 9.2e-65 218.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60335.1 - 3.5e-35 121.6 0.0 5.5e-35 120.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX60335.1 - 6.9e-05 22.9 1.8 0.0023 17.9 0.3 2.6 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX60335.1 - 0.0003 20.2 0.0 0.003 16.9 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX60335.1 - 0.014 14.4 0.0 0.021 13.8 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ORX60335.1 - 0.063 12.6 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ORX60335.1 - 0.08 12.5 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase WD40 PF00400.32 ORX60336.1 - 8.7e-28 96.0 6.5 6.6e-08 33.1 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX60336.1 - 2.7e-16 59.6 0.0 1.5e-05 25.2 0.0 5.1 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX60336.1 - 1.8e-07 30.5 0.2 0.058 12.3 0.0 3.4 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH_TPL PF17814.1 ORX60336.1 - 5.1e-06 26.0 0.9 1.3e-05 24.8 0.9 1.7 1 0 0 1 1 1 1 LisH-like dimerisation domain LisH_2 PF16045.5 ORX60336.1 - 0.0019 17.2 0.0 0.0038 16.2 0.0 1.4 1 0 0 1 1 1 1 LisH PALB2_WD40 PF16756.5 ORX60336.1 - 0.011 14.6 0.1 1.3 7.8 0.0 3.1 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain ELYS-bb PF16687.5 ORX60336.1 - 0.013 14.2 0.1 2.8 6.5 0.0 3.2 3 1 1 4 4 4 0 beta-propeller of ELYS nucleoporin LisH PF08513.11 ORX60336.1 - 0.19 11.8 0.0 0.41 10.7 0.0 1.6 1 0 0 1 1 1 0 LisH MSSP PF03940.13 ORX60337.1 - 0.00015 21.3 22.3 0.00066 19.2 12.2 2.7 1 1 1 2 2 2 2 Male specific sperm protein DUF92 PF01940.16 ORX60341.1 - 0.067 12.6 0.1 0.067 12.6 0.1 1.1 1 0 0 1 1 1 0 Integral membrane protein DUF92 ORC2 PF04084.14 ORX60343.1 - 1.2e-109 366.2 0.1 1.7e-109 365.8 0.1 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 2 DUF4551 PF15087.6 ORX60343.1 - 0.3 9.9 12.0 0.42 9.4 12.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Pkinase PF00069.25 ORX60344.1 - 1.2e-70 237.9 0.0 1.8e-70 237.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60344.1 - 6.8e-49 166.5 0.0 1.4e-48 165.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 ORX60344.1 - 6e-26 90.7 0.0 1.3e-25 89.6 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 ORX60344.1 - 1.6e-13 50.6 0.0 3.3e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX60344.1 - 6.3e-12 45.8 0.0 1.6e-11 44.5 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 ORX60344.1 - 2.1e-10 41.1 0.0 4e-10 40.2 0.0 1.5 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain Kinase-like PF14531.6 ORX60344.1 - 4.1e-07 29.6 0.0 9.4e-06 25.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like SAM_3 PF18016.1 ORX60344.1 - 0.027 14.3 0.0 0.12 12.2 0.0 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ORX60344.1 - 0.033 14.2 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 ORX60344.1 - 0.06 12.1 0.0 0.12 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase CENP-W PF15510.6 ORX60345.1 - 1.6e-05 25.1 0.0 1.9e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 CENP-W protein FXR_C1 PF16096.5 ORX60346.1 - 0.12 12.6 8.7 0.16 12.2 0.6 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 cobW PF02492.19 ORX60347.1 - 1.6e-50 171.1 0.7 3.9e-50 169.9 0.7 1.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ORX60347.1 - 7.9e-10 38.5 0.0 1.7e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain MMR_HSR1 PF01926.23 ORX60347.1 - 0.00062 19.8 0.1 0.0014 18.7 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX60347.1 - 0.0016 18.3 0.3 0.92 9.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase ATPase_2 PF01637.18 ORX60347.1 - 0.0022 17.9 0.7 0.0072 16.3 0.0 1.9 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea T2SSE PF00437.20 ORX60347.1 - 0.0075 15.4 0.1 0.017 14.2 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_18 PF13238.6 ORX60347.1 - 0.01 16.4 0.6 0.042 14.4 0.1 2.1 1 1 1 2 2 2 1 AAA domain GTP_EFTU PF00009.27 ORX60347.1 - 0.011 15.3 1.0 0.72 9.4 0.1 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX60347.1 - 0.02 15.2 0.1 0.061 13.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ORX60347.1 - 0.024 14.7 0.5 0.063 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ORX60347.1 - 0.035 14.6 0.1 0.09 13.3 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ORX60347.1 - 0.04 13.7 0.6 0.16 11.7 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 ORX60347.1 - 0.045 13.5 0.0 0.11 12.2 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 ORX60347.1 - 0.13 12.7 0.0 0.25 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ORX60347.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TIP120 PF08623.10 ORX60348.1 - 2.3e-60 203.2 1.3 2.3e-60 203.2 1.3 4.7 5 1 1 6 6 5 1 TATA-binding protein interacting (TIP20) HEAT PF02985.22 ORX60348.1 - 2.2e-14 52.3 27.8 0.15 12.4 0.0 13.6 15 0 0 15 15 13 5 HEAT repeat HEAT_2 PF13646.6 ORX60348.1 - 3.2e-14 53.1 13.4 0.0065 16.8 0.0 8.9 6 3 2 8 8 8 3 HEAT repeats HEAT_EZ PF13513.6 ORX60348.1 - 4.8e-13 49.3 13.6 1.3 9.6 0.0 11.1 11 1 2 13 13 11 3 HEAT-like repeat Adaptin_N PF01602.20 ORX60348.1 - 1.3e-06 27.3 29.0 0.002 16.8 1.1 6.1 4 1 1 6 6 6 3 Adaptin N terminal region TAF6_C PF07571.13 ORX60348.1 - 1.5e-06 28.4 0.1 0.052 13.9 0.0 4.3 4 0 0 4 4 4 2 TAF6 C-terminal HEAT repeat domain Xpo1 PF08389.12 ORX60348.1 - 2e-06 28.0 5.6 3 7.9 0.0 6.6 7 0 0 7 7 7 1 Exportin 1-like protein MMS19_N PF14500.6 ORX60348.1 - 7.5e-05 22.4 11.1 2.3 7.8 0.5 6.9 4 2 1 7 7 7 2 Dos2-interacting transcription regulator of RNA-Pol-II DUF3361 PF11841.8 ORX60348.1 - 0.00031 20.7 8.9 13 5.7 0.2 6.4 3 2 2 7 7 7 0 Domain of unknown function (DUF3361) API5 PF05918.11 ORX60348.1 - 0.00032 19.7 13.5 0.016 14.1 0.1 4.3 4 1 1 5 5 5 2 Apoptosis inhibitory protein 5 (API5) Vac14_Fab1_bd PF12755.7 ORX60348.1 - 0.00038 21.0 8.3 1.1 9.9 0.1 7.1 7 1 1 8 8 6 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 ORX60348.1 - 0.0007 19.5 3.5 3 8.0 0.0 5.9 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 ORX60348.1 - 0.00086 19.4 13.3 0.0016 18.6 0.3 6.5 6 1 2 8 8 8 1 V-ATPase subunit H DUF3453 PF11935.8 ORX60348.1 - 0.0034 17.0 0.5 3 7.4 0.0 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF3453) Cnd3 PF12719.7 ORX60348.1 - 0.013 14.7 6.7 0.53 9.4 0.7 4.7 3 1 1 4 4 4 0 Nuclear condensing complex subunits, C-term domain Cnd1 PF12717.7 ORX60348.1 - 0.013 15.5 19.8 0.17 11.9 0.8 6.4 5 2 1 6 6 6 0 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.7 ORX60348.1 - 0.013 15.4 15.9 6.6 6.6 0.0 6.7 3 2 2 6 6 6 0 Guanine nucleotide exchange factor in Golgi transport N-terminal CAS_CSE1 PF03378.15 ORX60348.1 - 0.023 13.2 4.6 0.066 11.7 0.2 3.4 3 2 0 3 3 3 0 CAS/CSE protein, C-terminus HPTransfase PF10090.9 ORX60348.1 - 0.065 13.0 0.0 0.22 11.4 0.0 1.8 1 1 0 1 1 1 0 Histidine phosphotransferase C-terminal domain B56 PF01603.20 ORX60348.1 - 0.16 10.9 5.4 0.34 9.8 0.1 3.3 3 1 0 4 4 4 0 Protein phosphatase 2A regulatory B subunit (B56 family) Pox_VLTF3 PF04947.14 ORX60348.1 - 0.45 10.2 2.8 1.2 8.8 1.0 2.5 2 1 1 3 3 3 0 Poxvirus Late Transcription Factor VLTF3 like Proteasom_PSMB PF10508.9 ORX60348.1 - 1.2 7.5 11.2 0.045 12.3 2.2 2.9 3 0 0 3 3 3 0 Proteasome non-ATPase 26S subunit SAPS PF04499.15 ORX60348.1 - 4.4 6.0 8.2 17 4.0 0.0 3.2 2 1 1 3 3 3 0 SIT4 phosphatase-associated protein RGS PF00615.19 ORX60349.1 - 2.2e-14 53.8 2.2 2.2e-14 53.8 2.2 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain RGS-like PF09128.11 ORX60349.1 - 4.4e-06 26.5 0.7 6.8e-06 25.9 0.6 1.4 1 1 0 1 1 1 1 Regulator of G protein signalling-like domain CDP-OH_P_transf PF01066.21 ORX60352.1 - 2.5e-14 53.8 0.5 2.5e-14 53.8 0.5 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase HC2 PF07382.11 ORX60353.1 - 2e-07 31.3 41.6 1.4e-05 25.2 11.9 3.0 1 1 2 3 3 3 2 Histone H1-like nucleoprotein HC2 DUF3324 PF11797.8 ORX60354.1 - 0.021 14.8 0.1 0.029 14.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function C-terminal (DUF3324) GT87 PF09594.10 ORX60354.1 - 0.025 14.3 0.8 0.038 13.7 0.8 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 87 Y_Y_Y PF07495.13 ORX60354.1 - 0.048 13.6 0.0 0.087 12.8 0.0 1.5 1 0 0 1 1 1 0 Y_Y_Y domain Wzt_C PF14524.6 ORX60354.1 - 0.073 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Wzt C-terminal domain APG17 PF04108.12 ORX60355.1 - 0.00032 19.9 21.6 0.00042 19.6 1.7 2.7 2 1 0 2 2 2 2 Autophagy protein Apg17 ER PF01133.17 ORX60355.1 - 0.18 11.8 2.5 0.28 11.2 0.5 2.2 2 0 0 2 2 2 0 Enhancer of rudimentary Snapin_Pallidin PF14712.6 ORX60355.1 - 2 8.9 16.0 0.13 12.7 4.2 3.8 3 1 0 3 3 3 0 Snapin/Pallidin ATG11 PF10377.9 ORX60356.1 - 3.1e-37 127.5 0.1 3.1e-37 127.5 0.1 3.4 4 1 1 5 5 5 1 Autophagy-related protein 11 CENP-F_leu_zip PF10473.9 ORX60356.1 - 0.0059 16.6 18.0 0.0059 16.6 18.0 3.9 3 1 0 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Bromo_TP PF07524.13 ORX60356.1 - 0.041 13.9 0.2 6 7.0 0.0 2.7 2 0 0 2 2 2 0 Bromodomain associated GAS PF13851.6 ORX60356.1 - 0.11 11.9 50.8 0.48 9.7 17.8 3.9 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding FliJ PF02050.16 ORX60356.1 - 2 8.6 51.5 0.28 11.4 13.3 5.0 4 1 1 5 5 5 0 Flagellar FliJ protein Kin17_mid PF10357.9 ORX60358.1 - 1.5e-45 154.2 0.1 1.7e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein DUF2470 PF10615.9 ORX60358.1 - 0.01 16.4 0.0 0.038 14.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2470) Abhydrolase_3 PF07859.13 ORX60359.1 - 1e-23 84.3 0.0 3.3e-23 82.6 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ORX60359.1 - 1.3e-14 53.9 0.1 1.6e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase OTCace PF00185.24 ORX60360.1 - 2.7e-50 170.5 0.0 4.4e-50 169.8 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 ORX60360.1 - 5.9e-47 159.4 0.3 9.1e-47 158.8 0.3 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Glyco_hydro_4 PF02056.16 ORX60360.1 - 0.0047 16.5 0.1 0.0083 15.7 0.1 1.4 1 0 0 1 1 1 1 Family 4 glycosyl hydrolase ARTD15_N PF18084.1 ORX60360.1 - 0.053 13.8 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 ARTD15 N-terminal domain Clat_adaptor_s PF01217.20 ORX60361.1 - 4.2e-46 156.4 4.9 6.4e-46 155.8 4.9 1.3 1 1 0 1 1 1 1 Clathrin adaptor complex small chain MATalpha_HMGbox PF04769.12 ORX60361.1 - 0.034 13.4 0.0 0.057 12.7 0.0 1.5 1 0 0 1 1 1 0 Mating-type protein MAT alpha 1 HMG-box RPN7 PF10602.9 ORX60362.1 - 1.7e-41 141.9 3.8 2.2e-41 141.5 2.0 2.0 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 ORX60362.1 - 1.1e-17 64.5 3.3 1.4e-17 64.1 0.3 2.6 2 1 0 2 2 2 1 PCI domain MAS20 PF02064.15 ORX60362.1 - 0.024 14.7 2.8 0.67 10.1 0.3 2.6 2 0 0 2 2 2 0 MAS20 protein import receptor Not3 PF04065.15 ORX60362.1 - 0.077 12.4 3.7 0.11 11.9 0.4 2.2 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component HSCB_C PF07743.13 ORX60362.1 - 0.3 11.6 3.7 2.1 8.9 0.0 3.3 3 1 0 3 3 3 0 HSCB C-terminal oligomerisation domain YlqD PF11068.8 ORX60362.1 - 2.8 8.3 6.7 2.2 8.7 0.8 2.6 2 0 0 2 2 2 0 YlqD protein TolA_bind_tri PF16331.5 ORX60363.1 - 0.00072 19.6 9.7 0.0059 16.7 0.7 3.0 3 0 0 3 3 3 2 TolA binding protein trimerisation MIT PF04212.18 ORX60363.1 - 0.0021 18.1 4.2 0.0021 18.1 4.2 2.8 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain KASH_CCD PF14662.6 ORX60363.1 - 0.0028 17.5 1.4 0.0028 17.5 1.4 2.9 3 0 0 3 3 3 2 Coiled-coil region of CCDC155 or KASH NRBF2_MIT PF17169.4 ORX60363.1 - 0.012 15.8 5.3 0.012 15.8 5.3 2.9 3 0 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 TSC22 PF01166.18 ORX60363.1 - 0.019 15.3 6.7 0.07 13.4 0.5 3.1 2 2 0 2 2 2 0 TSC-22/dip/bun family Phage_GP20 PF06810.11 ORX60363.1 - 0.085 12.7 0.2 0.085 12.7 0.2 2.3 2 0 0 2 2 2 0 Phage minor structural protein GP20 pPIWI_RE_REase PF18154.1 ORX60363.1 - 0.19 11.7 0.0 0.19 11.7 0.0 2.7 3 1 1 4 4 4 0 REase associating with pPIWI_RE Ax_dynein_light PF10211.9 ORX60363.1 - 0.19 11.6 18.5 0.087 12.8 1.7 3.0 3 0 0 3 3 3 0 Axonemal dynein light chain SHE3 PF17078.5 ORX60363.1 - 0.27 10.9 17.8 0.063 13.0 2.0 3.0 3 0 0 3 3 3 0 SWI5-dependent HO expression protein 3 HALZ PF02183.18 ORX60363.1 - 0.38 11.0 6.1 2.5 8.4 0.5 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper RBD-FIP PF09457.10 ORX60363.1 - 0.68 9.9 6.1 0.089 12.7 0.9 2.3 3 0 0 3 3 3 0 FIP domain bZIP_1 PF00170.21 ORX60363.1 - 1.2 9.3 13.1 3.4 7.8 0.3 3.7 3 1 0 3 3 3 0 bZIP transcription factor DUF4140 PF13600.6 ORX60363.1 - 1.5 9.3 13.2 0.51 10.8 0.9 3.6 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) LIN37 PF15306.6 ORX60363.1 - 2.1 8.5 21.9 0.21 11.8 5.1 3.1 2 1 1 3 3 3 0 LIN37 SlyX PF04102.12 ORX60363.1 - 3.7 8.2 15.1 4.4 8.0 0.8 3.7 3 0 0 3 3 3 0 SlyX Cnn_1N PF07989.11 ORX60363.1 - 6.7 6.9 17.1 0.21 11.7 2.0 3.6 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 kleA_kleC PF17383.2 ORX60363.1 - 6.9 7.1 9.8 4.1 7.8 0.5 3.4 3 0 0 3 3 3 0 Uncharacterized KorC regulated protein A GrpE PF01025.19 ORX60363.1 - 7.4 6.2 18.1 0.079 12.6 1.5 3.0 3 0 0 3 3 3 0 GrpE Methyltransf_25 PF13649.6 ORX60364.1 - 3.3e-11 43.7 0.0 7.8e-11 42.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX60364.1 - 5.3e-10 39.8 0.0 1.2e-09 38.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX60364.1 - 5.5e-10 39.3 0.0 9.4e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX60364.1 - 5.2e-09 36.1 0.0 6.1e-08 32.6 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX60364.1 - 0.00017 22.2 0.0 0.001 19.7 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX60364.1 - 0.00019 20.9 0.0 0.0016 18.0 0.0 2.3 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 ORX60364.1 - 0.041 13.2 0.0 0.49 9.7 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_29 PF03141.16 ORX60364.1 - 0.13 10.8 0.0 0.2 10.2 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase SMC_N PF02463.19 ORX60365.1 - 1.3e-77 260.2 4.2 1.9e-77 259.6 4.2 1.4 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ORX60365.1 - 6e-24 84.6 1.0 1.9e-23 83.0 0.1 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 ORX60365.1 - 3.3e-10 40.8 9.1 3.3e-10 40.8 9.1 6.9 3 3 2 5 5 5 1 AAA domain AAA_21 PF13304.6 ORX60365.1 - 5.1e-10 39.6 14.0 2.6e-06 27.4 0.0 3.9 3 2 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ORX60365.1 - 9.7e-07 28.8 3.2 9.7e-07 28.8 3.2 4.8 3 2 1 4 4 4 1 AAA ATPase domain AAA_29 PF13555.6 ORX60365.1 - 0.00013 21.7 0.0 0.00026 20.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 ORX60365.1 - 0.058 12.0 93.8 0.023 13.3 22.9 5.3 3 1 1 4 4 4 0 AAA domain ABC_tran PF00005.27 ORX60365.1 - 0.37 11.3 0.0 0.37 11.3 0.0 6.0 3 2 0 3 3 3 0 ABC transporter NPV_P10 PF05531.12 ORX60365.1 - 7.8 7.0 35.4 1.3 9.6 2.4 7.3 4 2 1 6 6 6 0 Nucleopolyhedrovirus P10 protein NCBP3 PF10309.9 ORX60366.1 - 2.4e-16 59.3 0.0 3.9e-16 58.6 0.0 1.3 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 DUF3110 PF11360.8 ORX60366.1 - 0.079 13.2 0.1 0.62 10.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3110) Pkinase PF00069.25 ORX60367.1 - 4.3e-72 242.6 0.1 4.3e-72 242.6 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60367.1 - 2.2e-52 177.9 0.2 2.2e-52 177.9 0.2 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase PBD PF00786.28 ORX60367.1 - 9.8e-21 73.9 0.0 2.1e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 ORX60367.1 - 4.1e-10 40.1 0.3 9.8e-10 38.9 0.3 1.7 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ORX60367.1 - 2.2e-06 27.2 0.0 4.4e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX60367.1 - 0.00022 20.1 12.6 0.0012 17.7 12.6 1.9 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX60367.1 - 0.0015 17.6 2.9 0.0044 16.0 2.9 1.6 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX60367.1 - 0.058 13.3 4.8 0.1 12.5 0.4 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family PH_11 PF15413.6 ORX60367.1 - 0.095 13.1 2.8 3.4 8.1 0.1 3.1 2 1 0 2 2 2 0 Pleckstrin homology domain RSB_motif PF16294.5 ORX60367.1 - 0.82 10.0 15.8 1.8 8.9 15.8 1.5 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif CDC45 PF02724.14 ORX60367.1 - 0.97 7.6 8.4 1.4 7.1 8.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PcfK PF14058.6 ORX60367.1 - 2.1 8.6 8.0 15 5.8 0.0 2.5 2 0 0 2 2 2 0 PcfK-like protein Phage_Gp23 PF10669.9 ORX60367.1 - 8.5 6.7 13.4 20 5.6 13.4 1.6 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF2058 PF09831.9 ORX60367.1 - 9.2 6.4 13.5 22 5.1 13.5 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DUF3915 PF13054.6 ORX60367.1 - 9.9 6.2 21.8 3.8e+02 1.1 21.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) AAA PF00004.29 ORX60368.1 - 9.2e-46 155.5 0.0 1.5e-36 125.7 0.0 2.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX60368.1 - 2e-15 56.3 0.0 4.5e-11 42.4 0.0 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX60368.1 - 6.7e-14 52.6 4.7 0.00035 21.0 0.0 4.3 2 2 2 4 4 4 3 AAA ATPase domain AAA_22 PF13401.6 ORX60368.1 - 3.4e-09 37.1 3.9 0.00022 21.5 0.1 4.2 3 2 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 ORX60368.1 - 2.6e-08 33.8 0.0 0.0088 15.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein DUF815 PF05673.13 ORX60368.1 - 3.2e-07 29.8 0.0 0.00011 21.4 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 ORX60368.1 - 6.8e-07 29.4 0.8 0.028 14.4 0.4 3.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX60368.1 - 2.1e-06 28.0 0.1 0.004 17.3 0.0 2.8 2 1 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ORX60368.1 - 2.3e-06 27.9 0.0 8.1e-05 22.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX60368.1 - 5.3e-06 26.3 0.0 0.00039 20.2 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 ORX60368.1 - 1.1e-05 25.1 0.0 0.092 12.2 0.0 2.3 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 ORX60368.1 - 1.9e-05 24.7 0.0 0.011 15.8 0.0 2.3 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ORX60368.1 - 2.5e-05 24.0 0.0 0.17 11.6 0.0 3.4 2 1 1 3 3 3 2 Sigma-54 interaction domain AAA_25 PF13481.6 ORX60368.1 - 4.2e-05 23.2 1.0 2.1 7.9 0.2 3.4 2 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 ORX60368.1 - 6.5e-05 23.3 0.0 0.15 12.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_18 PF13238.6 ORX60368.1 - 7.7e-05 23.3 0.1 0.54 10.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX60368.1 - 7.7e-05 22.4 0.0 0.02 14.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ORX60368.1 - 0.00018 21.0 0.1 0.039 13.3 0.1 3.0 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ORX60368.1 - 0.00021 20.6 0.0 0.0018 17.6 0.0 2.0 2 0 0 2 2 2 1 TIP49 P-loop domain ATPase PF06745.13 ORX60368.1 - 0.00032 20.1 0.1 0.62 9.4 0.0 3.2 3 0 0 3 3 3 1 KaiC ABC_tran PF00005.27 ORX60368.1 - 0.00038 21.0 0.1 1.4 9.5 0.0 2.7 2 1 0 2 2 2 2 ABC transporter Rad17 PF03215.15 ORX60368.1 - 0.00066 19.7 0.6 0.99 9.3 0.0 3.4 2 2 1 3 3 3 1 Rad17 P-loop domain TniB PF05621.11 ORX60368.1 - 0.00091 18.7 0.0 1.3 8.4 0.0 3.3 2 1 1 3 3 3 1 Bacterial TniB protein TsaE PF02367.17 ORX60368.1 - 0.0016 18.5 0.0 0.38 10.8 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AFG1_ATPase PF03969.16 ORX60368.1 - 0.002 17.1 0.0 1 8.2 0.0 2.2 2 0 0 2 2 2 2 AFG1-like ATPase AAA_30 PF13604.6 ORX60368.1 - 0.002 17.9 0.0 0.68 9.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ORX60368.1 - 0.0023 17.9 0.5 0.23 11.3 0.0 3.0 2 1 1 3 3 3 1 NACHT domain AAA_3 PF07726.11 ORX60368.1 - 0.0054 16.6 0.0 0.054 13.4 0.0 2.5 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ORX60368.1 - 0.0095 15.8 0.0 0.29 11.0 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_24 PF13479.6 ORX60368.1 - 0.012 15.3 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX60368.1 - 0.014 15.7 0.5 4.2 7.7 0.1 2.9 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 ORX60368.1 - 0.015 14.5 0.0 0.77 8.9 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain AAA_23 PF13476.6 ORX60368.1 - 0.016 15.8 0.0 0.32 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 ORX60368.1 - 0.016 14.6 0.0 0.25 10.8 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein Roc PF08477.13 ORX60368.1 - 0.019 15.2 0.0 0.58 10.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Sigma54_activ_2 PF14532.6 ORX60368.1 - 0.04 14.0 0.0 0.43 10.7 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 ORX60368.1 - 0.053 13.3 0.0 0.3 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ORX60368.1 - 0.055 12.5 0.0 5.8 5.9 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_28 PF13521.6 ORX60368.1 - 0.059 13.6 0.0 0.65 10.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ORX60368.1 - 0.079 12.2 0.0 5 6.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Zot PF05707.12 ORX60368.1 - 0.13 11.9 0.1 4.8 6.8 0.0 2.7 2 1 0 3 3 3 0 Zonular occludens toxin (Zot) Viral_helicase1 PF01443.18 ORX60368.1 - 0.17 11.6 0.0 0.45 10.2 0.0 1.7 2 0 0 2 2 1 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 ORX60368.1 - 0.19 12.1 0.0 18 5.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ORX60368.1 - 0.25 10.4 0.0 0.61 9.1 0.0 1.6 2 0 0 2 2 1 0 Parvovirus non-structural protein NS1 zf-H2C2_2 PF13465.6 ORX60369.1 - 5.9e-14 51.8 14.7 3.3e-07 30.4 3.2 4.3 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2 PF00096.26 ORX60369.1 - 8.5e-11 41.7 28.6 5e-06 26.7 4.3 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ORX60369.1 - 7.9e-07 29.2 5.5 0.39 11.1 0.1 3.4 3 0 0 3 3 3 3 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX60369.1 - 7.8e-06 26.3 23.5 0.02 15.7 2.2 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 ORX60369.1 - 0.00018 21.8 8.3 0.24 11.8 0.1 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ORX60369.1 - 0.0012 18.8 9.8 0.09 12.8 0.3 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf-MYST PF17772.1 ORX60369.1 - 0.16 11.6 1.5 0.32 10.6 0.0 2.2 3 0 0 3 3 3 0 MYST family zinc finger domain zf-LYAR PF08790.11 ORX60369.1 - 3 7.8 7.6 4.6 7.2 0.1 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger VASt PF16016.5 ORX60370.1 - 5.7e-30 104.8 0.1 2.2e-29 102.8 0.1 2.0 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 ORX60370.1 - 1.3e-20 74.2 3.2 2.4e-20 73.3 3.2 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 ORX60370.1 - 1.9e-09 37.9 0.6 1e-08 35.6 0.6 2.3 2 0 0 2 2 2 1 PH domain BAR PF03114.18 ORX60370.1 - 0.00061 19.5 1.2 0.0013 18.4 1.2 1.5 1 0 0 1 1 1 1 BAR domain GRAM PF02893.20 ORX60370.1 - 0.00071 19.4 0.0 0.0023 17.8 0.0 1.8 1 0 0 1 1 1 1 GRAM domain PH_9 PF15410.6 ORX60370.1 - 0.0092 16.3 0.0 0.03 14.7 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Glutaredoxin PF00462.24 ORX60371.1 - 1.2e-17 63.8 0.0 2e-17 63.2 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin DUF836 PF05768.14 ORX60371.1 - 0.002 18.5 0.0 0.0028 18.0 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Thioredoxin_9 PF14595.6 ORX60371.1 - 0.0041 16.9 0.0 0.0049 16.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 ORX60371.1 - 0.0072 16.8 0.3 0.015 15.7 0.2 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_3 PF13192.6 ORX60371.1 - 0.022 14.8 0.0 0.044 13.8 0.0 1.5 1 1 0 1 1 1 0 Thioredoxin domain Thioredoxin PF00085.20 ORX60371.1 - 0.048 13.6 0.1 0.058 13.4 0.1 1.3 1 1 0 1 1 1 0 Thioredoxin DNA_pol3_delta PF06144.13 ORX60371.1 - 0.05 13.4 0.1 0.066 13.0 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase III, delta subunit TraF PF13728.6 ORX60371.1 - 0.13 12.1 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein DSBA PF01323.20 ORX60371.1 - 0.19 11.5 0.4 0.92 9.2 0.1 1.9 1 1 0 2 2 2 0 DSBA-like thioredoxin domain DUF3759 PF12585.8 ORX60372.1 - 2.7e-38 129.9 6.5 3.2e-38 129.6 6.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) DUF2939 PF11159.8 ORX60372.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2939) CCDC53 PF10152.9 ORX60373.1 - 0.067 13.6 0.2 0.079 13.4 0.2 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex PHTB1_C PF14728.6 ORX60374.1 - 0.1 11.7 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 PTHB1 C-terminus RCC1 PF00415.18 ORX60376.1 - 3.9e-23 81.8 2.7 1.7e-05 25.3 0.0 5.7 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 ORX60376.1 - 8.4e-16 58.2 0.2 3.3e-11 43.4 0.0 3.3 3 0 0 3 3 3 2 BTB/POZ domain Ank_2 PF12796.7 ORX60376.1 - 5.7e-13 49.3 0.1 5.6e-12 46.1 0.1 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX60376.1 - 4.4e-12 46.3 0.7 3.2e-10 40.3 0.2 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX60376.1 - 2.1e-09 36.8 1.2 0.0071 16.8 0.1 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ORX60376.1 - 4e-08 33.4 1.6 0.00083 19.7 0.1 3.8 3 0 0 3 3 3 2 Ankyrin repeat RCC1_2 PF13540.6 ORX60376.1 - 3e-07 30.1 0.2 3e-07 30.1 0.2 4.0 5 0 0 5 5 5 1 Regulator of chromosome condensation (RCC1) repeat Ank_5 PF13857.6 ORX60376.1 - 4.5e-07 30.0 0.3 4.4e-06 26.9 0.1 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Mito_carr PF00153.27 ORX60377.1 - 7.5e-28 96.3 2.3 1.2e-15 57.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein VTC PF09359.10 ORX60378.1 - 1.6e-81 273.8 0.0 2.6e-81 273.0 0.0 1.4 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 ORX60378.1 - 1.5e-12 47.8 1.8 3.3e-12 46.7 1.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 ORX60378.1 - 5.3e-05 23.3 28.1 0.018 15.0 1.4 3.4 2 1 1 3 3 3 2 SPX domain Yip1 PF04893.17 ORX60378.1 - 0.96 9.1 4.9 1.4 8.6 0.5 2.1 1 1 1 2 2 2 0 Yip1 domain SAP18 PF06487.12 ORX60379.1 - 5.4e-31 107.6 0.1 1.1e-30 106.7 0.1 1.4 1 1 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) Methyltransf_24 PF13578.6 ORX60379.1 - 0.066 14.2 0.1 2.1 9.4 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain NTP_transf_2 PF01909.23 ORX60380.1 - 1.3e-12 47.8 0.0 2.9e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 ORX60380.1 - 2.2e-06 27.8 1.6 4.9e-06 26.7 0.1 2.4 2 0 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 ORX60380.1 - 0.015 15.4 0.0 0.031 14.3 0.0 1.5 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Foie-gras_1 PF11817.8 ORX60381.1 - 2.9e-35 122.1 0.7 1.9e-17 63.8 2.3 2.3 1 1 1 2 2 2 2 Foie gras liver health family 1 Gryzun PF07919.12 ORX60381.1 - 1.2e-31 110.2 0.0 2e-30 106.1 0.0 2.0 1 1 0 1 1 1 1 Gryzun, putative trafficking through Golgi TPR_12 PF13424.6 ORX60381.1 - 0.0034 17.6 1.7 0.0054 17.0 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Gryzun-like PF12742.7 ORX60381.1 - 0.0052 16.8 0.1 0.012 15.6 0.1 1.6 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking BatD PF13584.6 ORX60381.1 - 0.075 11.8 0.0 0.16 10.7 0.0 1.5 1 0 0 1 1 1 0 Oxygen tolerance TPR_19 PF14559.6 ORX60381.1 - 0.095 13.2 0.0 0.26 11.8 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat dsDNA_bind PF01984.20 ORX60382.1 - 2.4e-29 101.8 7.3 3e-29 101.5 7.3 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain ANAPC4_WD40 PF12894.7 ORX60382.1 - 0.025 14.9 0.1 0.057 13.7 0.1 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain EF-1_beta_acid PF10587.9 ORX60382.1 - 0.04 14.4 0.6 0.04 14.4 0.6 2.6 3 0 0 3 3 3 0 Eukaryotic elongation factor 1 beta central acidic region Mso1_Sec1_bdg PF14475.6 ORX60383.1 - 2.2e-09 36.8 0.1 4.9e-09 35.6 0.1 1.6 1 0 0 1 1 1 1 Sec1-binding region of Mso1 DEAD PF00270.29 ORX60384.1 - 2.1e-43 148.1 1.4 2.1e-43 148.1 0.3 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX60384.1 - 7.9e-33 113.1 0.1 3.1e-31 108.0 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX60384.1 - 4.3e-06 26.8 0.0 7.2e-06 26.1 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ORX60384.1 - 0.00044 20.6 1.0 0.0043 17.4 0.4 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ORX60384.1 - 0.0067 16.2 0.1 0.013 15.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 ORX60384.1 - 0.025 14.5 0.1 0.086 12.8 0.1 1.9 1 1 0 1 1 1 0 Flavivirus DEAD domain UTP25 PF06862.12 ORX60384.1 - 0.026 13.3 0.1 2.7 6.7 0.0 2.2 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 ORX60384.1 - 0.035 13.4 0.0 0.074 12.4 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit TPT PF03151.16 ORX60386.1 - 1.2e-27 97.0 14.1 1.5e-27 96.7 14.1 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ORX60386.1 - 2.8e-13 50.2 27.1 9.6e-07 29.0 12.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX60386.1 - 0.00049 19.4 20.6 0.0071 15.6 20.7 2.0 1 1 0 1 1 1 1 Nucleotide-sugar transporter PUNUT PF16913.5 ORX60386.1 - 0.86 8.8 22.1 2.8 7.1 22.1 1.6 1 1 0 1 1 1 0 Purine nucleobase transmembrane transport CTP_synth_N PF06418.14 ORX60387.1 - 3.9e-125 416.5 0.0 5.5e-125 416.0 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 ORX60387.1 - 1.3e-59 201.2 0.0 2.1e-59 200.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX60387.1 - 1.4e-07 31.5 0.0 3.3e-07 30.3 0.0 1.6 1 1 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 ORX60387.1 - 0.028 14.5 0.0 0.037 14.1 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arrestin_C PF02752.22 ORX60388.1 - 3.8e-08 33.9 0.0 5.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain ERG4_ERG24 PF01222.17 ORX60389.1 - 2.2e-137 458.3 23.2 2.5e-137 458.2 23.2 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family R3H-assoc PF13902.6 ORX60390.1 - 9.1e-06 26.1 0.3 2e-05 25.0 0.1 1.7 2 0 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.22 ORX60390.1 - 0.002 18.1 0.0 0.0055 16.7 0.0 1.7 1 0 0 1 1 1 1 R3H domain SWIM PF04434.17 ORX60391.1 - 0.078 12.7 0.4 0.16 11.7 0.4 1.5 1 0 0 1 1 1 0 SWIM zinc finger G_glu_transpept PF01019.21 ORX60393.1 - 1.9e-169 564.7 0.0 2.3e-169 564.4 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Sel1 PF08238.12 ORX60395.1 - 8.1e-70 229.7 76.2 2.2e-06 28.1 0.1 26.3 27 1 1 28 28 27 16 Sel1 repeat TPR_1 PF00515.28 ORX60395.1 - 2e-09 36.9 19.3 0.32 10.9 0.0 12.9 14 0 0 14 14 14 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX60395.1 - 5.1e-07 29.3 37.6 0.19 11.9 0.0 14.2 17 0 0 17 17 17 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX60395.1 - 6.6e-07 29.6 39.4 0.018 15.8 0.2 14.8 10 4 5 15 15 15 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX60395.1 - 0.00015 22.2 53.1 0.032 14.8 0.1 10.1 11 1 1 12 12 11 4 Tetratricopeptide repeat TPR_6 PF13174.6 ORX60395.1 - 0.00034 21.1 31.2 0.21 12.3 0.0 12.5 14 0 0 14 14 12 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX60395.1 - 0.00062 19.8 9.3 15 6.1 0.2 10.1 12 0 0 12 12 10 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX60395.1 - 0.0023 17.6 18.2 3.2 7.5 0.0 10.2 11 0 0 11 11 10 1 TPR repeat TPR_7 PF13176.6 ORX60395.1 - 0.0047 16.9 18.5 14 6.0 0.0 9.8 11 0 0 11 11 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX60395.1 - 0.024 15.3 0.2 0.24 12.1 0.1 10.7 10 3 2 13 13 12 0 Tetratricopeptide repeat Fes1 PF08609.10 ORX60395.1 - 0.096 13.6 0.1 21 6.1 0.0 2.9 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 TPR_12 PF13424.6 ORX60395.1 - 0.74 10.1 0.0 0.74 10.1 0.0 14.2 14 2 1 15 15 15 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX60395.1 - 0.77 9.7 9.0 7 6.7 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_21 PF09976.9 ORX60395.1 - 4.7 6.9 21.5 0.97 9.1 5.6 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat-like domain Podoplanin PF05808.11 ORX60396.1 - 3e-06 27.4 0.1 5.2e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Podoplanin GRP PF07172.11 ORX60396.1 - 0.42 11.3 4.9 0.77 10.5 4.9 1.4 1 0 0 1 1 1 0 Glycine rich protein family Methyltr_RsmF_N PF17125.5 ORX60396.1 - 0.43 11.1 2.5 0.28 11.7 0.2 1.8 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF Beta-APP PF03494.13 ORX60396.1 - 0.54 10.1 8.2 0.36 10.7 3.9 2.3 2 0 0 2 2 2 0 Beta-amyloid peptide (beta-APP) Ndc1_Nup PF09531.10 ORX60396.1 - 2.5 6.7 6.6 2.9 6.5 6.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SPX PF03105.19 ORX60396.1 - 4.3 7.2 5.5 5.6 6.8 5.5 1.3 1 0 0 1 1 1 0 SPX domain DNA_pol_B PF00136.21 ORX60398.1 - 3.3e-103 345.9 0.0 6.7e-103 344.8 0.0 1.5 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ORX60398.1 - 3.9e-30 105.1 0.0 6.5e-30 104.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-DNA_Pol PF08996.10 ORX60398.1 - 6.7e-30 104.2 4.5 1.2e-29 103.3 4.5 1.4 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DUF1744 PF08490.12 ORX60398.1 - 0.00029 19.5 0.0 0.00054 18.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) WD40 PF00400.32 ORX60399.1 - 1e-42 143.3 18.9 1.9e-06 28.4 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX60399.1 - 4.6e-10 39.7 1.4 0.0087 16.3 0.0 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX60399.1 - 3.5e-08 32.5 3.7 0.022 13.4 0.1 4.4 2 2 1 4 4 4 2 Nucleoporin Nup120/160 F-box PF00646.33 ORX60399.1 - 4.2e-08 32.9 0.8 8.7e-08 31.9 0.8 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ORX60399.1 - 3.2e-07 30.1 0.3 6.4e-07 29.2 0.3 1.5 1 0 0 1 1 1 1 F-box-like WD40_like PF17005.5 ORX60399.1 - 2.3e-06 27.2 0.0 0.00052 19.4 0.0 2.2 2 1 0 2 2 2 1 WD40-like domain PQQ_2 PF13360.6 ORX60399.1 - 0.00038 20.1 0.2 0.048 13.2 0.1 2.4 1 1 1 2 2 2 2 PQQ-like domain Ge1_WD40 PF16529.5 ORX60399.1 - 0.00042 19.4 0.3 0.26 10.2 0.0 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein F-box_4 PF15966.5 ORX60399.1 - 0.0019 18.1 1.7 0.0049 16.7 1.4 1.9 1 1 0 1 1 1 1 F-box STE PF02200.16 ORX60399.1 - 0.029 14.8 0.3 0.25 11.8 0.1 2.6 2 1 1 3 3 3 0 STE like transcription factor PALB2_WD40 PF16756.5 ORX60399.1 - 0.033 13.1 0.7 15 4.4 0.0 3.5 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain GPI2 PF06432.11 ORX60400.1 - 3.7e-95 318.6 14.2 4.2e-95 318.4 14.2 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase FA_desaturase PF00487.24 ORX60400.1 - 0.76 9.6 10.2 0.11 12.3 2.2 2.5 1 1 1 2 2 2 0 Fatty acid desaturase PAM2 PF07145.15 ORX60401.1 - 0.00061 19.3 0.7 0.036 13.8 0.0 2.8 2 0 0 2 2 2 2 Ataxin-2 C-terminal region EXOSC1 PF10447.9 ORX60402.1 - 7.6e-15 55.5 2.6 1.7e-13 51.1 2.6 2.1 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 ORX60402.1 - 1.1e-13 50.8 1.0 2.1e-13 49.8 0.5 1.8 2 0 0 2 2 2 1 Exosome complex exonuclease RRP4 N-terminal region S1 PF00575.23 ORX60402.1 - 0.0045 17.3 0.6 0.045 14.1 0.6 2.2 1 1 0 1 1 1 1 S1 RNA binding domain CM_1 PF07736.11 ORX60402.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 Chorismate mutase type I Kinesin PF00225.23 ORX60403.1 - 3.1e-105 351.8 1.8 4.4e-105 351.3 1.8 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX60403.1 - 2.8e-26 92.2 1.3 4.5e-26 91.6 0.1 2.0 2 0 0 2 2 2 1 Microtubule binding Metalloenzyme PF01676.18 ORX60404.1 - 2.5e-77 259.6 0.1 2.9e-77 259.4 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily iPGM_N PF06415.13 ORX60404.1 - 1.1e-75 253.8 0.0 1.5e-75 253.3 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Phosphodiest PF01663.22 ORX60404.1 - 5.9e-06 26.1 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX60404.1 - 0.0013 18.2 0.0 0.0025 17.2 0.0 1.6 1 1 0 1 1 1 1 Sulfatase PglZ PF08665.12 ORX60404.1 - 0.024 14.7 0.0 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 PglZ domain AP_endonuc_2 PF01261.24 ORX60404.1 - 0.026 14.0 0.0 0.15 11.4 0.0 2.2 2 1 0 2 2 2 0 Xylose isomerase-like TIM barrel Alk_phosphatase PF00245.20 ORX60404.1 - 0.033 13.2 0.2 0.095 11.6 0.1 1.8 2 0 0 2 2 2 0 Alkaline phosphatase Glutaredoxin PF00462.24 ORX60407.1 - 2.4e-18 66.1 0.0 7.5e-18 64.5 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin DUF836 PF05768.14 ORX60407.1 - 0.00066 20.0 0.0 0.00092 19.6 0.0 1.4 1 1 0 1 1 1 1 Glutaredoxin-like domain (DUF836) zf_C2H2_ZHX PF18387.1 ORX60408.1 - 0.0016 18.1 6.6 0.43 10.2 0.2 2.7 2 0 0 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_12 PF18658.1 ORX60408.1 - 0.0019 17.7 2.3 0.14 11.7 0.4 2.7 1 1 1 2 2 2 1 Zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ORX60408.1 - 0.0033 17.7 0.1 0.0091 16.3 0.1 1.8 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX60408.1 - 0.0058 17.4 7.4 0.67 11.0 0.8 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ORX60408.1 - 0.0073 17.0 0.9 0.023 15.4 0.2 2.2 2 1 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 ORX60408.1 - 0.0083 15.9 0.9 0.018 14.8 0.9 1.5 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2 PF00096.26 ORX60408.1 - 0.041 14.3 6.6 1.3 9.6 0.3 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ORX60408.1 - 0.054 13.8 1.8 0.13 12.6 0.2 2.3 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ORX60408.1 - 0.069 13.6 1.3 0.11 12.9 0.3 2.0 2 0 0 2 2 2 0 Zinc-finger of C2H2 type DUF629 PF04780.12 ORX60408.1 - 0.084 11.4 1.0 0.15 10.6 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-LYAR PF08790.11 ORX60408.1 - 0.12 12.3 3.0 1.2 9.1 0.1 2.6 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_6 PF13912.6 ORX60408.1 - 0.36 10.9 2.8 0.78 9.8 0.3 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger His_Phos_1 PF00300.22 ORX60409.1 - 2.3e-11 43.8 0.1 1.1e-09 38.2 0.0 2.4 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 ORX60409.1 - 0.0069 15.8 0.3 0.014 14.8 0.0 1.6 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) Cellulase PF00150.18 ORX60410.1 - 9.3e-13 48.2 0.1 1.8e-12 47.3 0.1 1.5 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 ORX60411.1 - 3e-46 157.9 0.0 3.9e-46 157.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60411.1 - 3.6e-28 98.6 0.0 4.3e-28 98.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX60411.1 - 0.00021 20.7 0.0 0.00041 19.8 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX60411.1 - 0.00023 21.2 0.2 0.00062 19.8 0.2 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ORX60411.1 - 0.18 10.7 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase SPC25 PF06703.11 ORX60412.1 - 3.2e-35 121.3 2.6 4e-35 121.0 2.6 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) SPRY PF00622.28 ORX60413.1 - 2.9e-23 82.3 0.2 5.4e-23 81.4 0.2 1.5 1 0 0 1 1 1 1 SPRY domain Pkinase PF00069.25 ORX60415.1 - 2.6e-23 82.7 0.0 3.4e-23 82.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60415.1 - 2.1e-09 37.1 0.0 2.7e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX60415.1 - 7e-09 35.0 0.0 9.3e-09 34.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX60415.1 - 0.047 13.6 0.0 2.5 7.9 0.0 2.4 1 1 0 2 2 2 0 Phosphotransferase enzyme family Asp PF00026.23 ORX60416.1 - 1.1e-69 235.3 0.1 1.2e-69 235.1 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX60416.1 - 6.6e-16 59.0 3.1 2.4e-06 27.9 0.1 3.2 2 1 1 3 3 3 3 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX60416.1 - 2.4e-07 31.3 0.1 0.0042 17.7 0.0 2.8 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX60416.1 - 5.4e-06 26.9 0.0 0.066 13.8 0.0 2.6 2 1 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 ORX60416.1 - 3.6e-05 23.6 0.0 0.00066 19.5 0.0 2.2 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal PQQ_2 PF13360.6 ORX60416.1 - 0.053 13.1 0.0 0.3 10.6 0.0 1.9 2 0 0 2 2 2 0 PQQ-like domain HMG_box PF00505.19 ORX60417.1 - 3.3e-25 88.3 3.5 3.3e-25 88.3 3.5 1.4 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX60417.1 - 3.1e-18 66.1 4.1 4.7e-18 65.6 4.1 1.3 1 0 0 1 1 1 1 HMG-box domain CHDNT PF08073.12 ORX60417.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 CHDNT (NUC034) domain tRNA-synt_2b PF00587.25 ORX60418.1 - 9.5e-24 84.3 0.0 3.1e-23 82.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX60418.1 - 1.1e-10 41.7 5.1 1.6e-10 41.2 5.1 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF2203 PF09969.9 ORX60418.1 - 0.0019 18.9 6.2 0.79 10.4 0.1 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2203) CW_binding_1 PF01473.20 ORX60418.1 - 0.052 13.9 0.2 0.12 12.8 0.2 1.6 1 0 0 1 1 1 0 Putative cell wall binding repeat Pyr_redox_2 PF07992.14 ORX60419.1 - 1.7e-70 237.6 1.0 2.4e-70 237.1 1.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ORX60419.1 - 2.1e-29 102.0 0.4 5.2e-29 100.7 0.3 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ORX60419.1 - 4.4e-23 81.6 4.0 3.5e-20 72.3 0.4 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX60419.1 - 2.3e-14 53.4 0.2 8.9e-11 41.6 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX60419.1 - 9.2e-11 41.7 0.9 1e-09 38.3 0.1 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX60419.1 - 2e-10 39.9 7.2 0.00069 18.4 0.5 4.1 3 1 1 4 4 4 2 HI0933-like protein AlaDh_PNT_C PF01262.21 ORX60419.1 - 1.3e-06 27.8 3.4 0.0046 16.3 0.4 2.5 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ORX60419.1 - 1.3e-05 25.6 0.4 0.015 15.8 0.1 2.4 2 0 0 2 2 2 2 Putative NAD(P)-binding 3HCDH_N PF02737.18 ORX60419.1 - 1.8e-05 24.7 4.2 0.0002 21.3 0.5 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GIDA PF01134.22 ORX60419.1 - 3.7e-05 23.0 4.6 0.00018 20.8 2.0 2.5 2 1 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ORX60419.1 - 4.6e-05 23.6 1.2 4.6e-05 23.6 1.2 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 ORX60419.1 - 4.7e-05 22.8 0.6 0.006 16.0 0.0 2.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 ORX60419.1 - 6.1e-05 22.3 2.5 6.1e-05 22.3 2.5 3.4 3 1 1 4 4 4 1 FAD binding domain K_oxygenase PF13434.6 ORX60419.1 - 0.00095 18.4 0.3 0.038 13.1 0.0 2.7 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 ORX60419.1 - 0.002 17.4 0.2 0.002 17.4 0.2 2.2 2 1 1 3 3 3 1 Thi4 family DAO PF01266.24 ORX60419.1 - 0.0033 17.0 1.1 0.0033 17.0 1.1 3.3 4 0 0 4 4 4 1 FAD dependent oxidoreductase UDPG_MGDP_dh_N PF03721.14 ORX60419.1 - 0.0041 16.7 1.9 0.0099 15.5 1.9 1.8 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 ORX60419.1 - 0.0061 15.9 6.8 0.52 9.5 0.2 2.9 2 1 1 3 3 3 2 FAD binding domain XdhC_C PF13478.6 ORX60419.1 - 0.0097 16.4 0.6 0.39 11.2 0.2 2.3 2 0 0 2 2 2 1 XdhC Rossmann domain F420_oxidored PF03807.17 ORX60419.1 - 0.052 14.1 3.5 0.59 10.8 0.2 3.3 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Amino_oxidase PF01593.24 ORX60419.1 - 0.1 11.9 3.7 0.75 9.0 0.1 2.7 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase DFP PF04127.15 ORX60419.1 - 0.2 11.5 0.9 3.9 7.3 0.1 2.3 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein TrkA_N PF02254.18 ORX60419.1 - 0.39 11.0 1.7 3.1 8.1 0.3 2.7 2 1 0 2 2 2 0 TrkA-N domain adh_short PF00106.25 ORX60419.1 - 0.81 9.1 4.6 8.6 5.8 0.2 2.3 2 0 0 2 2 2 0 short chain dehydrogenase Lycopene_cycl PF05834.12 ORX60419.1 - 3.3 6.7 7.3 0.76 8.8 0.8 2.9 2 2 1 3 3 3 0 Lycopene cyclase protein RINGv PF12906.7 ORX60420.1 - 3.5e-11 43.1 5.0 1.6e-10 40.9 2.0 2.4 2 0 0 2 2 2 2 RING-variant domain Glyco_transf_20 PF00982.21 ORX60421.1 - 1.5e-153 511.9 0.0 2e-153 511.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX60421.1 - 5.8e-73 244.9 0.0 1.3e-72 243.7 0.0 1.6 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ORX60421.1 - 0.0009 19.0 0.0 0.47 10.1 0.0 3.0 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase Peptidase_M16_C PF05193.21 ORX60422.1 - 3.7e-18 66.2 0.0 5.8e-15 55.8 0.0 2.5 2 0 0 2 2 2 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX60422.1 - 1.3e-07 31.7 0.0 1.1e-05 25.5 0.0 2.5 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 ORX60422.1 - 0.5 9.5 4.5 0.66 9.0 1.2 2.3 2 0 0 2 2 2 0 Peptidase M16C associated Ricin_B_lectin PF00652.22 ORX60424.1 - 2.5e-06 27.8 0.0 6.2e-06 26.5 0.0 1.7 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DUF3759 PF12585.8 ORX60424.1 - 0.00013 21.9 0.0 0.00022 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) RicinB_lectin_2 PF14200.6 ORX60424.1 - 0.00014 22.5 0.0 0.0022 18.7 0.0 2.6 1 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain-like BSD PF03909.17 ORX60425.1 - 2.5e-11 43.4 0.6 5.6e-11 42.3 0.6 1.6 1 0 0 1 1 1 1 BSD domain ApoLp-III PF07464.11 ORX60425.1 - 0.05 13.7 0.1 0.084 13.0 0.1 1.3 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Sugar_tr PF00083.24 ORX60426.1 - 1.3e-116 390.2 23.8 1.6e-116 389.9 23.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX60426.1 - 2.3e-22 79.4 25.0 9.9e-22 77.3 17.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Chromo PF00385.24 ORX60428.1 - 8.4e-11 41.6 0.4 1.2e-10 41.1 0.4 1.3 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Tudor-knot PF11717.8 ORX60428.1 - 0.053 13.4 1.0 0.065 13.1 1.0 1.4 1 1 0 1 1 1 0 RNA binding activity-knot of a chromodomain DUF5345 PF17280.2 ORX60429.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Vps39_2 PF10367.9 ORX60430.1 - 1.5e-34 118.7 2.8 3e-34 117.8 0.4 2.6 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 ORX60430.1 - 1.1e-22 81.0 0.0 3.2e-22 79.4 0.0 1.8 1 1 0 1 1 1 1 CNH domain Vps39_1 PF10366.9 ORX60430.1 - 1.1e-17 64.2 8.6 2.2e-14 53.7 0.2 4.6 4 1 1 5 5 5 2 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 ORX60430.1 - 4.5e-09 36.3 9.4 2.3e-07 30.8 1.5 3.7 4 0 0 4 4 4 2 Region in Clathrin and VPS TPR_1 PF00515.28 ORX60430.1 - 0.022 14.6 4.2 1.8 8.6 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX60430.1 - 0.062 13.8 5.0 3.9 8.1 0.1 4.7 3 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX60430.1 - 0.3 11.4 1.0 1.7 9.1 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX60430.1 - 0.82 9.9 5.9 8.3 6.8 0.1 4.6 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF2514 PF10721.9 ORX60431.1 - 0.39 10.8 7.8 0.65 10.0 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) VIR_N PF15912.5 ORX60431.1 - 0.45 10.1 6.8 0.76 9.3 6.8 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal PTPRCAP PF15713.5 ORX60431.1 - 0.5 10.6 9.3 0.84 9.9 9.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2407_C PF13373.6 ORX60431.1 - 1.8 8.8 3.8 3.2 7.9 3.8 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain CDC45 PF02724.14 ORX60431.1 - 1.8 6.8 12.6 2.5 6.3 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PA26 PF04636.13 ORX60431.1 - 3 6.7 7.6 4.3 6.1 7.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Mem_trans PF03547.18 ORX60431.1 - 4.8 5.5 4.6 7.2 4.9 4.6 1.2 1 0 0 1 1 1 0 Membrane transport protein TFB6 PF17110.5 ORX60431.1 - 6.8 6.4 8.8 15 5.3 8.8 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Endonuc_Holl PF10107.9 ORX60431.1 - 7 6.5 11.1 12 5.8 11.1 1.2 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Peptidase_S49_N PF08496.10 ORX60431.1 - 8.3 6.5 13.2 16 5.5 13.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal F-box-like PF12937.7 ORX60432.1 - 0.00022 21.0 0.9 0.0012 18.7 0.9 2.4 1 0 0 1 1 1 1 F-box-like ICMT PF04140.14 ORX60433.1 - 1.3e-26 92.8 1.0 2.3e-26 92.0 1.0 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ORX60433.1 - 3.9e-10 40.1 0.9 1e-09 38.7 0.9 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 ORX60433.1 - 0.00024 20.7 1.2 0.0003 20.4 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 ORX60433.1 - 0.0029 17.1 1.4 0.0039 16.7 1.4 1.4 1 0 0 1 1 1 1 NnrU protein Ist1 PF03398.14 ORX60434.1 - 9.6e-65 217.5 0.8 1.2e-64 217.2 0.8 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway zf-RING_4 PF14570.6 ORX60435.1 - 2.3e-22 78.5 11.9 4.6e-22 77.5 11.9 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 ORX60435.1 - 3.7e-07 29.9 0.0 8.1e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 ORX60435.1 - 7.3e-07 29.0 8.5 1.6e-06 27.9 8.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX60435.1 - 0.0011 19.2 12.0 0.0037 17.6 12.0 2.0 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ORX60435.1 - 0.0012 18.6 12.4 0.0063 16.4 9.2 2.7 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 Nup35_RRM PF05172.13 ORX60435.1 - 0.012 15.6 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-UDP PF14569.6 ORX60435.1 - 0.057 13.5 2.8 0.13 12.4 2.8 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger Baculo_IE-1 PF05290.11 ORX60435.1 - 0.067 13.1 2.7 0.14 12.1 2.7 1.5 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) Nup35_RRM_2 PF14605.6 ORX60435.1 - 0.1 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-C3HC4 PF00097.25 ORX60435.1 - 0.14 12.1 10.9 0.29 11.0 10.9 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DNA_pol_phi PF04931.13 ORX60435.1 - 0.23 9.5 0.8 1.8 6.5 0.2 2.1 1 1 1 2 2 2 0 DNA polymerase phi DUF733 PF05306.11 ORX60435.1 - 1.6 9.1 5.5 11 6.4 2.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF733) SelP_N PF04592.14 ORX60435.1 - 4.8 6.5 13.9 0.17 11.3 7.4 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region UPF0220 PF05255.11 ORX60436.1 - 2.1e-41 141.2 0.4 2.4e-41 141.1 0.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) Acyl-CoA_dh_N PF02771.16 ORX60438.1 - 2.4e-29 102.2 0.3 7.2e-29 100.7 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 ORX60438.1 - 1.5e-28 99.9 1.4 3.1e-28 98.9 1.4 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX60438.1 - 1.8e-21 76.2 0.1 3.5e-21 75.2 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX60438.1 - 7.7e-08 32.7 0.3 1.4e-07 31.9 0.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HSP70 PF00012.20 ORX60439.1 - 5.8e-07 28.1 0.2 5.2e-06 24.9 0.0 1.9 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ORX60439.1 - 0.0023 16.8 0.0 0.064 12.1 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein HLH PF00010.26 ORX60440.1 - 1.5e-18 66.4 0.3 8.5e-18 64.1 0.3 2.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain DUF4611 PF15387.6 ORX60440.1 - 0.17 12.1 5.7 0.61 10.3 0.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) CPP1-like PF11833.8 ORX60440.1 - 3.2 7.4 4.6 2.1 8.0 1.8 2.1 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like NOC3p PF07540.11 ORX60441.1 - 7.9e-31 106.4 1.1 3.2e-30 104.4 1.1 2.2 1 0 0 1 1 1 1 Nucleolar complex-associated protein CBF PF03914.17 ORX60441.1 - 2e-24 86.5 0.7 2e-24 86.5 0.7 2.6 2 1 0 2 2 2 1 CBF/Mak21 family PIEZO PF15917.5 ORX60441.1 - 2.8 7.4 12.3 0.015 14.8 2.9 1.9 2 0 0 2 2 2 0 Piezo TPR_2 PF07719.17 ORX60443.1 - 8.6e-35 116.0 22.6 8.9e-07 28.6 0.6 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 ORX60443.1 - 9.1e-35 117.1 23.6 8.3e-10 38.1 0.5 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat DnaJ PF00226.31 ORX60443.1 - 7.2e-28 96.5 1.8 7.2e-28 96.5 1.8 3.4 5 0 0 5 5 4 1 DnaJ domain TPR_19 PF14559.6 ORX60443.1 - 5.1e-25 87.8 19.0 4e-09 36.9 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ORX60443.1 - 5.7e-18 65.3 12.5 6.6e-05 23.5 0.0 6.8 4 3 2 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ORX60443.1 - 1e-17 63.5 18.0 0.00079 19.1 2.6 8.9 6 1 2 8 8 8 5 TPR repeat TPR_14 PF13428.6 ORX60443.1 - 4.8e-17 61.2 17.6 0.061 14.2 0.2 8.8 4 3 4 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX60443.1 - 8.1e-17 61.3 19.2 0.00063 20.0 2.9 6.8 4 2 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX60443.1 - 5.8e-15 54.2 19.9 0.021 15.0 0.2 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 ORX60443.1 - 7e-14 51.1 15.9 0.049 14.0 0.0 7.9 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX60443.1 - 2.5e-09 37.2 8.5 0.00049 20.2 0.1 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX60443.1 - 7.7e-08 32.5 13.2 0.0058 16.8 0.0 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ORX60443.1 - 1.3e-07 31.4 8.3 0.018 14.4 0.1 4.4 1 1 1 4 4 4 2 MalT-like TPR region TPR_7 PF13176.6 ORX60443.1 - 1.3e-06 28.0 11.5 2.2 8.5 0.1 7.0 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX60443.1 - 2.1e-06 27.4 17.2 0.013 15.3 0.1 6.8 8 0 0 8 8 8 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX60443.1 - 3.4e-06 27.0 16.0 0.33 11.1 0.0 7.2 7 1 1 8 8 7 2 Fis1 C-terminal tetratricopeptide repeat TPR_4 PF07721.14 ORX60443.1 - 0.0015 19.0 1.0 16 6.4 0.0 4.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX60443.1 - 0.0034 17.9 21.2 2.5 8.9 0.0 7.2 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 ORX60443.1 - 0.0039 17.5 12.1 1.1 9.6 0.0 4.8 2 2 4 6 6 6 2 Tetratricopeptide repeat MIT PF04212.18 ORX60443.1 - 0.023 14.7 12.1 0.27 11.3 0.3 4.7 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Lambda_Kil PF06301.11 ORX60443.1 - 0.036 13.7 2.3 31 4.3 0.0 4.2 3 1 1 4 4 4 0 Bacteriophage lambda Kil protein SHNi-TPR PF10516.9 ORX60443.1 - 0.077 12.5 9.3 0.21 11.0 0.2 3.4 4 0 0 4 4 4 0 SHNi-TPR BTAD PF03704.17 ORX60443.1 - 0.13 12.6 10.3 0.98 9.8 0.1 4.1 3 2 0 3 3 3 0 Bacterial transcriptional activator domain Acyl-CoA_ox_N PF14749.6 ORX60443.1 - 2.6 8.6 8.5 1.4 9.5 1.1 2.8 3 0 0 3 3 2 0 Acyl-coenzyme A oxidase N-terminal DUF5113 PF17140.4 ORX60443.1 - 3.6 7.4 11.0 1.3 8.8 1.4 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5113) BTB_2 PF02214.22 ORX60444.1 - 4e-16 59.2 0.7 3.6e-10 40.1 0.1 2.6 2 1 0 2 2 2 2 BTB/POZ domain zf-C2HC_2 PF13913.6 ORX60445.1 - 0.0017 18.2 0.8 0.0027 17.6 0.8 1.3 1 0 0 1 1 1 1 zinc-finger of a C2HC-type DUF1922 PF09082.10 ORX60445.1 - 0.097 13.0 0.2 0.14 12.5 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) zf-C2H2 PF00096.26 ORX60446.1 - 1.5e-37 126.0 47.2 2.3e-05 24.6 0.4 9.2 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX60446.1 - 3.4e-26 89.6 45.3 0.00053 20.6 2.3 9.2 9 0 0 9 9 9 8 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX60446.1 - 2.3e-17 62.5 56.5 8.9e-07 29.1 2.4 9.1 9 0 0 9 9 9 6 Zinc-finger double domain zf-met PF12874.7 ORX60446.1 - 1.3e-14 54.0 18.8 0.0007 19.9 0.3 7.1 7 0 0 7 7 7 4 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX60446.1 - 2.5e-10 40.4 20.9 0.0018 18.5 0.7 6.1 6 0 0 6 6 6 4 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX60446.1 - 4e-07 29.9 34.1 0.0047 16.9 0.4 7.2 8 0 0 8 8 7 5 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX60446.1 - 4.8e-07 30.0 20.3 0.041 14.2 4.0 4.3 3 1 1 4 4 4 3 C2H2-type zinc ribbon FOXP-CC PF16159.5 ORX60446.1 - 9.1e-05 23.0 32.8 0.29 11.8 0.5 7.4 1 1 7 8 8 8 4 FOXP coiled-coil domain zf-LYAR PF08790.11 ORX60446.1 - 0.0015 18.4 16.9 0.53 10.2 1.0 5.8 5 0 0 5 5 5 2 LYAR-type C2HC zinc finger zf-C2H2_11 PF16622.5 ORX60446.1 - 0.0066 16.2 24.9 2.8 7.8 0.5 6.7 8 0 0 8 8 8 3 zinc-finger C2H2-type zf_UBZ PF18439.1 ORX60446.1 - 0.0079 15.8 13.2 0.64 9.7 0.4 6.0 6 0 0 6 6 6 1 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 ORX60446.1 - 0.016 15.2 28.0 0.018 15.0 1.1 6.4 4 3 3 7 7 7 0 BED zinc finger zf-C2HC_2 PF13913.6 ORX60446.1 - 0.023 14.6 14.9 0.24 11.3 0.4 5.7 7 0 0 7 7 6 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 ORX60446.1 - 0.034 13.9 25.2 4.7 7.1 0.0 7.3 8 0 0 8 8 8 0 C2H2-type zinc-finger domain zf-C2H2_3rep PF18868.1 ORX60446.1 - 0.09 13.4 22.6 0.25 12.0 3.6 5.3 1 1 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_aberr PF17017.5 ORX60446.1 - 0.13 12.4 20.4 2.3 8.3 1.6 6.0 2 2 4 6 6 6 0 Aberrant zinc-finger zf_Hakai PF18408.1 ORX60446.1 - 0.31 10.8 24.8 0.58 9.9 0.0 6.3 7 0 0 7 7 7 0 C2H2 Hakai zinc finger domain Pkinase PF00069.25 ORX60447.1 - 1.3e-70 237.8 0.0 1.9e-70 237.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60447.1 - 9.7e-37 126.6 0.0 1.5e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 ORX60447.1 - 1.8e-17 63.3 0.3 5.5e-08 32.9 0.0 2.9 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 ORX60447.1 - 1.7e-11 44.0 0.0 3.9e-08 33.0 0.0 2.7 3 1 0 3 3 3 2 Kinase-like Pkinase_fungal PF17667.1 ORX60447.1 - 0.02 13.7 0.0 0.038 12.8 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase RhoGAP PF00620.27 ORX60448.1 - 4e-35 120.9 0.0 7.1e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DUF5491 PF17595.2 ORX60448.1 - 0.089 13.1 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5491) zf-RING_2 PF13639.6 ORX60451.1 - 0.0022 18.3 10.0 0.004 17.4 10.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ORX60451.1 - 0.28 11.1 8.0 0.46 10.4 8.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SR-25 PF10500.9 ORX60451.1 - 9 5.8 6.2 14 5.2 6.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Mis12 PF05859.12 ORX60452.1 - 9.3e-20 71.1 5.5 9.3e-20 71.1 5.5 2.1 1 1 1 2 2 2 1 Mis12 protein DUF1664 PF07889.12 ORX60452.1 - 0.99 9.5 5.4 2.4 8.2 2.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) BTB PF00651.31 ORX60453.1 - 0.00082 19.6 0.0 0.0014 18.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain F-box PF00646.33 ORX60454.1 - 1.3e-07 31.3 0.6 3e-07 30.2 0.6 1.6 1 0 0 1 1 1 1 F-box domain DUSP PF06337.12 ORX60454.1 - 4.1e-07 30.5 0.1 3.6e-06 27.5 0.0 2.3 2 0 0 2 2 2 1 DUSP domain F-box-like PF12937.7 ORX60454.1 - 5.3e-07 29.4 0.2 1.6e-06 27.9 0.2 1.8 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ORX60454.1 - 0.00037 20.3 0.2 0.00037 20.3 0.2 1.9 2 0 0 2 2 2 1 F-box DUF4428 PF14471.6 ORX60454.1 - 0.016 15.1 2.0 0.034 14.1 2.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4428) DZR PF12773.7 ORX60454.1 - 0.48 10.5 8.8 1.4 9.0 4.6 2.4 1 1 2 3 3 3 0 Double zinc ribbon zf-C3HC4_3 PF13920.6 ORX60454.1 - 6.3 6.7 7.0 1.1e+02 2.8 7.0 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DYW_deaminase PF14432.6 ORX60455.1 - 0.044 13.7 0.4 0.088 12.7 0.4 1.5 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases Fis1_TPR_C PF14853.6 ORX60457.1 - 4e-22 78.0 2.9 6.4e-22 77.4 2.9 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 ORX60457.1 - 1.4e-13 50.2 0.1 2.2e-13 49.6 0.1 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 ORX60457.1 - 0.00048 20.0 3.7 0.00048 20.0 3.7 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX60457.1 - 0.004 17.3 1.0 0.0065 16.7 1.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ORX60457.1 - 0.0075 16.0 4.3 0.016 15.0 4.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF357 PF04010.13 ORX60457.1 - 0.012 15.7 0.0 0.03 14.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF357) TPR_16 PF13432.6 ORX60457.1 - 0.014 16.0 3.3 0.015 15.9 1.3 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX60457.1 - 0.024 14.9 1.2 0.041 14.2 0.4 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX60457.1 - 0.059 13.4 3.1 0.21 11.7 3.1 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX60457.1 - 0.073 13.7 2.4 0.1 13.3 0.9 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPPK_C PF12555.8 ORX60457.1 - 0.088 12.9 2.9 0.14 12.2 2.9 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal COPI_C PF06957.11 ORX60457.1 - 0.1 11.4 0.1 0.15 10.8 0.1 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus zf-RING_2 PF13639.6 ORX60458.1 - 4.6e-12 46.1 8.3 4.6e-12 46.1 8.3 2.5 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX60458.1 - 1.6e-08 34.2 8.2 1.6e-08 34.2 8.2 2.3 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX60458.1 - 3.2e-08 33.7 6.7 3.2e-08 33.7 6.7 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ORX60458.1 - 3.1e-07 30.0 2.9 3.1e-07 30.0 2.9 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 ORX60458.1 - 5.2e-07 29.4 9.6 5.2e-07 29.4 9.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX60458.1 - 7.1e-06 25.8 5.8 7.1e-06 25.8 5.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX60458.1 - 2.4e-05 24.3 5.4 2.4e-05 24.3 5.4 2.5 3 0 0 3 3 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX60458.1 - 0.00045 20.0 5.8 0.00045 20.0 5.8 1.9 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ORX60458.1 - 0.00052 19.9 7.3 0.00052 19.9 7.3 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ORX60458.1 - 0.0012 18.9 2.7 0.0028 17.7 2.7 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_9 PF14369.6 ORX60458.1 - 0.004 17.4 4.1 0.01 16.1 0.2 3.0 2 0 0 2 2 2 1 zinc-ribbon Prok-RING_1 PF14446.6 ORX60458.1 - 0.15 12.0 6.5 8.6 6.4 0.1 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 RINGv PF12906.7 ORX60458.1 - 0.33 11.1 8.8 1 9.6 8.8 1.9 1 0 0 1 1 1 0 RING-variant domain Zn-ribbon_8 PF09723.10 ORX60458.1 - 1.3 9.2 5.4 13 6.0 0.4 2.9 2 0 0 2 2 2 0 Zinc ribbon domain Zn_ribbon_17 PF17120.5 ORX60458.1 - 4.9 6.9 14.2 0.092 12.4 6.6 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Vps39_2 PF10367.9 ORX60458.1 - 9.3 6.7 6.9 5.2 7.6 0.6 2.8 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 Malic_M PF03949.15 ORX60459.1 - 4.7e-80 268.6 0.0 6.7e-80 268.1 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX60459.1 - 1.9e-55 187.5 0.0 3.1e-55 186.8 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Peptidase_M76 PF09768.9 ORX60460.1 - 7.8e-32 110.4 4.7 1.1e-31 110.0 4.7 1.2 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 ORX60460.1 - 0.0012 18.6 0.1 0.0031 17.4 0.1 1.7 1 1 0 1 1 1 1 SprT-like family WLM PF08325.10 ORX60460.1 - 0.043 13.9 0.0 0.061 13.4 0.0 1.3 1 0 0 1 1 1 0 WLM domain Tox-MPTase2 PF15638.6 ORX60460.1 - 0.16 11.7 0.0 0.27 11.0 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase toxin 2 TH1 PF04858.13 ORX60461.1 - 1.4e-83 281.5 0.1 1.8e-83 281.2 0.1 1.0 1 0 0 1 1 1 1 TH1 protein PDDEXK_6 PF04720.12 ORX60461.1 - 0.053 13.5 0.0 0.097 12.6 0.0 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function PX PF00787.24 ORX60462.1 - 3.3e-20 72.1 0.1 3.3e-20 72.1 0.1 2.3 2 0 0 2 2 2 1 PX domain FIVAR PF07554.13 ORX60462.1 - 0.069 13.9 1.3 0.17 12.7 1.3 1.6 1 0 0 1 1 1 0 FIVAR domain Sec2p PF06428.11 ORX60463.1 - 9.9e-11 41.5 4.9 1.5e-10 40.9 4.9 1.3 1 0 0 1 1 1 1 GDP/GTP exchange factor Sec2p Mg_chelatase_C PF13335.6 ORX60463.1 - 0.026 15.2 0.6 0.044 14.4 0.2 1.6 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal Not1 PF04054.15 ORX60466.1 - 5.3e-149 496.1 3.7 5.3e-149 496.1 3.7 1.9 2 0 0 2 2 2 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 ORX60466.1 - 4.8e-100 333.6 6.0 4.8e-100 333.6 6.0 2.0 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 ORX60466.1 - 3.2e-70 235.2 0.1 3.2e-70 235.2 0.1 3.2 3 1 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 ORX60466.1 - 1.1e-53 181.1 7.1 1.1e-53 181.1 7.1 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 ORX60466.1 - 5.9e-43 146.5 3.0 5.9e-43 146.5 3.0 3.5 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat Pex14_N PF04695.13 ORX60466.1 - 5.2 7.7 21.9 1.4 9.6 6.9 3.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IQCJ-SCHIP1 PF15157.6 ORX60467.1 - 8.5 6.2 9.2 0.6 9.9 2.6 2.1 2 0 0 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif PrmA PF06325.13 ORX60469.1 - 1.7e-12 47.3 0.1 2.5e-12 46.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 ORX60469.1 - 1.6e-11 44.1 0.0 2.2e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain UPF0020 PF01170.18 ORX60469.1 - 6.1e-08 32.6 0.0 4.7e-06 26.4 0.0 2.3 1 1 1 2 2 2 1 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.15 ORX60469.1 - 6.2e-07 29.2 0.0 8e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 ORX60469.1 - 2.5e-06 28.1 0.2 7.1e-06 26.6 0.1 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX60469.1 - 1.5e-05 24.9 0.2 3.1e-05 23.8 0.2 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ORX60469.1 - 0.014 14.9 0.0 0.023 14.3 0.0 1.4 1 1 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_11 PF08241.12 ORX60469.1 - 0.02 15.5 0.1 0.063 13.9 0.1 2.0 1 1 0 1 1 1 0 Methyltransferase domain N6-adenineMlase PF10237.9 ORX60469.1 - 0.031 14.1 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase AIRS_C PF02769.22 ORX60469.1 - 0.032 14.3 0.0 0.046 13.9 0.0 1.2 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain Methyltransf_16 PF10294.9 ORX60469.1 - 0.055 13.2 0.1 0.12 12.1 0.0 1.6 2 0 0 2 2 2 0 Lysine methyltransferase p450 PF00067.22 ORX60470.1 - 2.2e-42 145.4 0.0 2.7e-42 145.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX60471.1 - 1.8e-33 116.0 0.0 3.7e-33 115.0 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX60472.1 - 1e-37 130.0 0.0 1.5e-37 129.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ORX60473.1 - 2.1e-38 132.3 0.0 2.8e-38 131.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAA_hydrolase_N PF09298.11 ORX60473.1 - 0.17 12.1 0.0 0.51 10.5 0.0 1.7 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal p450 PF00067.22 ORX60474.1 - 3.9e-13 49.0 0.0 4.3e-13 48.8 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 PseudoU_synth_2 PF00849.22 ORX60475.1 - 1.2e-22 80.8 0.0 1.4e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 RNA pseudouridylate synthase Tad_C PF09977.9 ORX60475.1 - 0.026 15.8 0.2 1.5 10.1 0.1 2.1 1 1 1 2 2 2 0 Putative Tad-like Flp pilus-assembly LysM PF01476.20 ORX60476.1 - 0.0022 18.0 0.0 0.99 9.5 0.0 2.3 2 0 0 2 2 2 2 LysM domain Homeobox_KN PF05920.11 ORX60476.1 - 0.17 11.8 0.3 26 4.8 0.0 2.5 2 0 0 2 2 2 0 Homeobox KN domain Fungus-induced PF10917.8 ORX60476.1 - 0.28 11.5 0.3 0.28 11.5 0.3 2.6 2 1 1 3 3 3 0 Fungus-induced protein Helicase_C PF00271.31 ORX60477.1 - 6.3e-11 42.6 0.0 2.3e-10 40.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Suv3_C_1 PF18147.1 ORX60477.1 - 1.5e-10 40.8 0.0 2.6e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 SUV3_C PF12513.8 ORX60477.1 - 0.03 14.3 1.6 0.098 12.6 1.6 1.9 1 0 0 1 1 1 0 Mitochondrial degradasome RNA helicase subunit C terminal WD40 PF00400.32 ORX60478.1 - 2.7e-69 227.4 31.7 6.2e-07 30.0 0.2 12.2 12 0 0 12 12 12 11 WD domain, G-beta repeat Utp13 PF08625.11 ORX60478.1 - 9.7e-52 174.6 0.6 1.7e-51 173.9 0.6 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain ANAPC4_WD40 PF12894.7 ORX60478.1 - 1.1e-18 67.4 15.8 0.19 12.1 0.0 9.2 2 2 7 9 9 9 9 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX60478.1 - 3.5e-08 32.5 20.2 0.041 12.5 0.1 8.3 3 3 4 8 8 8 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX60478.1 - 9.1e-07 28.5 2.9 0.0043 16.4 0.1 5.3 2 2 4 6 6 6 1 WD40-like domain Hira PF07569.11 ORX60478.1 - 3.3e-05 23.7 1.4 0.86 9.3 0.0 5.0 3 1 1 4 4 4 1 TUP1-like enhancer of split Utp12 PF04003.12 ORX60478.1 - 0.0012 19.1 0.1 0.0042 17.4 0.0 1.9 2 0 0 2 2 2 1 Dip2/Utp12 Family Copper-fist PF00649.18 ORX60479.1 - 3.8e-18 64.7 2.9 3.8e-18 64.7 2.9 2.4 1 1 1 2 2 2 1 Copper fist DNA binding domain Phage_holin_3_6 PF07332.11 ORX60480.1 - 0.65 10.0 2.1 2 8.5 2.1 1.8 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Kei1 PF08552.11 ORX60480.1 - 9.4 6.1 8.9 2.6e+02 1.4 8.9 2.5 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Hydrolase_like PF13242.6 ORX60481.1 - 2.5e-10 40.2 0.0 5e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 ORX60481.1 - 1.6e-08 34.6 0.0 3.6e-08 33.4 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX60481.1 - 0.0027 18.0 0.0 0.95 9.7 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX60481.1 - 0.083 13.0 0.0 9.1 6.3 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase PfkB PF00294.24 ORX60482.1 - 4.7e-19 68.8 0.0 6.2e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NAD_binding_10 PF13460.6 ORX60483.1 - 1.4e-09 38.1 0.0 2.1e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX60483.1 - 0.037 13.6 0.0 0.073 12.6 0.0 1.5 2 0 0 2 2 2 0 NmrA-like family Arylesterase PF01731.20 ORX60484.1 - 5.1e-11 42.6 0.2 1.7e-10 41.0 0.1 1.9 2 0 0 2 2 2 1 Arylesterase Str_synth PF03088.16 ORX60484.1 - 0.00064 19.8 0.0 0.0042 17.2 0.0 2.3 3 0 0 3 3 3 1 Strictosidine synthase SGL PF08450.12 ORX60484.1 - 0.016 14.8 0.0 0.057 13.0 0.0 2.1 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Pantoate_ligase PF02569.15 ORX60485.1 - 8.7e-96 320.2 0.1 9.9e-96 320.0 0.1 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Hormone_3 PF00159.18 ORX60485.1 - 0.09 12.9 0.1 0.25 11.4 0.0 1.8 2 0 0 2 2 2 0 Pancreatic hormone peptide TMEM70 PF06979.12 ORX60486.1 - 1.4e-06 28.7 0.4 2e-06 28.2 0.4 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex DUF2973 PF11189.8 ORX60486.1 - 0.16 12.1 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2973) Nop14 PF04147.12 ORX60487.1 - 0.0052 15.1 17.5 0.0064 14.8 17.5 1.1 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 ORX60487.1 - 0.51 8.6 13.4 0.018 13.4 7.3 1.6 2 0 0 2 2 2 0 CDC45-like protein Nop53 PF07767.11 ORX60487.1 - 4.1 6.7 13.4 3.5 6.9 9.1 2.1 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) CDV3 PF15359.6 ORX60487.1 - 5.9 7.4 12.5 0.41 11.1 7.4 1.7 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Nas2_N PF18265.1 ORX60488.1 - 6e-27 93.4 0.3 8.8e-27 92.8 0.3 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain GRASP55_65 PF04495.14 ORX60488.1 - 9.7e-09 35.7 0.0 1.6e-08 34.9 0.0 1.3 1 1 0 1 1 1 1 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 ORX60488.1 - 2.4e-06 27.3 0.0 4.1e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ORX60488.1 - 0.00064 20.0 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain RhoGEF PF00621.20 ORX60489.1 - 6.2e-23 82.0 0.0 1.3e-22 80.9 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain CNH PF00780.22 ORX60489.1 - 3.4e-08 33.4 0.0 1.6e-06 27.9 0.0 2.3 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 ORX60489.1 - 0.01 15.9 0.0 1 9.4 0.0 3.2 3 0 0 3 3 3 0 Pleckstrin homology domain PH PF00169.29 ORX60489.1 - 0.021 15.3 1.1 0.094 13.2 0.1 2.6 3 0 0 3 3 3 0 PH domain PhyH PF05721.13 ORX60490.1 - 1.1e-21 78.0 0.1 2.4e-14 54.1 0.0 2.1 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Muted PF14942.6 ORX60491.1 - 0.011 16.0 7.0 0.016 15.5 7.0 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Blo-t-5 PF11642.8 ORX60491.1 - 0.019 14.9 2.2 0.086 12.8 0.5 2.0 1 1 1 2 2 2 0 Mite allergen Blo t 5 DUF3848 PF12959.7 ORX60491.1 - 0.074 13.1 2.6 0.11 12.6 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) Exonuc_VII_L PF02601.15 ORX60491.1 - 0.083 12.4 4.2 0.085 12.4 4.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TOPRIM_C PF16898.5 ORX60491.1 - 0.14 12.5 3.5 0.13 12.5 1.5 1.8 1 1 1 2 2 2 0 C-terminal associated domain of TOPRIM FapA PF03961.13 ORX60491.1 - 0.46 9.0 1.7 0.53 8.8 1.7 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cnd1 PF12717.7 ORX60492.1 - 3.4e-52 176.7 0.4 4.4e-49 166.6 0.2 3.1 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 ORX60492.1 - 8.2e-39 133.1 0.1 1.8e-38 132.0 0.1 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT_2 PF13646.6 ORX60492.1 - 4.6e-08 33.3 0.4 0.0021 18.4 0.0 4.1 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 ORX60492.1 - 7.8e-05 22.6 0.3 2.4 8.6 0.0 5.3 5 0 0 5 5 4 1 HEAT repeat Cnd3 PF12719.7 ORX60492.1 - 0.00034 19.9 6.5 0.00045 19.5 1.1 3.1 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain DUF4763 PF15960.5 ORX60492.1 - 0.0098 15.2 0.4 0.11 11.8 0.4 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4763) HEAT_EZ PF13513.6 ORX60492.1 - 0.015 15.8 0.2 33 5.1 0.0 4.3 4 0 0 4 4 4 0 HEAT-like repeat Adaptin_N PF01602.20 ORX60492.1 - 0.02 13.5 0.2 0.02 13.5 0.2 3.9 4 1 0 5 5 5 0 Adaptin N terminal region YtxC PF08812.11 ORX60492.1 - 0.035 13.7 0.2 0.11 12.1 0.2 1.8 1 0 0 1 1 1 0 YtxC-like family Chrome_Resist PF09828.9 ORX60492.1 - 0.064 13.7 0.6 0.28 11.6 0.2 2.4 2 0 0 2 2 2 0 Chromate resistance exported protein NAM-associated PF14303.6 ORX60492.1 - 0.24 12.1 0.0 0.24 12.1 0.0 3.6 3 1 0 3 3 2 0 No apical meristem-associated C-terminal domain Voldacs PF03517.13 ORX60492.1 - 1.6 8.8 7.3 0.88 9.7 3.0 2.5 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling PBP1_TM PF14812.6 ORX60492.1 - 2.2 8.7 5.2 9.3 6.7 2.8 3.2 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FR47 PF08445.10 ORX60493.1 - 9.1e-09 35.2 0.0 2.6e-08 33.7 0.0 1.7 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 ORX60493.1 - 4.6e-06 26.9 0.0 1e-05 25.8 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX60493.1 - 4.7e-05 23.7 0.0 0.00013 22.4 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ORX60493.1 - 0.00041 21.0 0.0 0.00084 20.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ORX60493.1 - 0.016 15.2 0.0 0.036 14.0 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ORX60493.1 - 0.048 13.2 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase RNase_PH PF01138.21 ORX60494.1 - 2.8e-24 86.1 0.0 7.5e-24 84.7 0.0 1.7 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ORX60494.1 - 4.3e-10 39.5 0.0 7.9e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 FA_FANCE PF11510.8 ORX60494.1 - 0.042 13.2 0.1 0.074 12.4 0.1 1.4 1 0 0 1 1 1 0 Fanconi Anaemia group E protein FANCE MFS_5 PF05631.14 ORX60495.1 - 6e-68 229.3 9.4 9.6e-68 228.7 9.4 1.2 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 ORX60495.1 - 1.9e-10 40.2 35.9 3.7e-10 39.3 35.9 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF3040 PF11239.8 ORX60495.1 - 0.54 10.6 5.6 2.4 8.5 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) DUF2976 PF11190.8 ORX60495.1 - 6.6 6.6 8.5 6.2 6.7 0.1 3.8 3 1 1 4 4 4 0 Protein of unknown function (DUF2976) Ribosomal_S19 PF00203.21 ORX60496.1 - 1.7e-34 117.6 0.3 2e-34 117.3 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 MMtag PF10159.9 ORX60497.1 - 2.4e-31 107.8 1.8 2.4e-31 107.8 1.8 2.3 2 0 0 2 2 2 1 Multiple myeloma tumor-associated DUF5316 PF17247.2 ORX60497.1 - 0.023 14.7 0.4 0.062 13.3 0.4 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5316) SOG2 PF10428.9 ORX60497.1 - 0.046 12.9 23.0 0.055 12.7 23.0 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein TMEM214 PF10151.9 ORX60497.1 - 9.5 4.5 7.6 14 3.9 7.6 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Ank_2 PF12796.7 ORX60500.1 - 2.3e-08 34.5 0.0 4e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX60500.1 - 1e-06 28.9 0.1 3.7e-06 27.1 0.0 2.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX60500.1 - 1.6e-06 28.5 0.0 3.6e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX60500.1 - 1.9e-05 24.7 0.1 0.00013 22.1 0.0 2.3 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ORX60500.1 - 0.0001 22.6 0.0 0.00021 21.6 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeat RrnaAD PF00398.20 ORX60500.1 - 0.055 12.5 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PTP_tm PF18861.1 ORX60501.1 - 0.00088 19.3 0.1 0.0015 18.6 0.1 1.4 1 0 0 1 1 1 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J EphA2_TM PF14575.6 ORX60501.1 - 0.0082 17.0 0.0 0.012 16.5 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain PAP2_3 PF14378.6 ORX60501.1 - 0.023 14.4 0.1 0.033 13.9 0.1 1.2 1 0 0 1 1 1 0 PAP2 superfamily ApoO PF09769.9 ORX60501.1 - 0.065 13.2 0.5 0.12 12.3 0.5 1.4 1 0 0 1 1 1 0 Apolipoprotein O EF1G PF00647.19 ORX60502.1 - 1.9e-47 159.7 0.3 3.7e-47 158.8 0.3 1.5 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 ORX60502.1 - 3.7e-12 46.3 0.0 1.2e-11 44.7 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ORX60502.1 - 6.5e-12 45.6 0.0 1.7e-11 44.3 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ORX60502.1 - 6.8e-07 29.6 0.0 1.7e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX60502.1 - 3.7e-05 23.7 0.0 9.7e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX60502.1 - 5.4e-05 23.3 0.0 0.00014 22.0 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 ORX60502.1 - 0.0049 17.1 0.0 0.019 15.3 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain DPPIV_N PF00930.21 ORX60503.1 - 2.2e-57 194.5 0.1 9.6e-57 192.3 0.0 1.9 2 0 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 ORX60503.1 - 4.7e-46 156.9 0.1 7.8e-46 156.2 0.1 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ORX60503.1 - 9.1e-09 35.3 0.0 5.9e-08 32.6 0.0 2.1 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Esterase PF00756.20 ORX60503.1 - 0.00011 21.9 0.0 0.00038 20.2 0.0 1.9 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 ORX60503.1 - 0.00037 21.2 0.4 0.00037 21.2 0.4 2.1 2 1 1 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX60503.1 - 0.0035 17.0 0.2 0.0088 15.7 0.2 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase_phd PF10503.9 ORX60503.1 - 0.077 12.5 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase AXE1 PF05448.12 ORX60503.1 - 0.09 11.4 0.1 0.31 9.7 0.1 1.8 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 ORX60503.1 - 0.16 11.5 0.1 0.83 9.2 0.1 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family CTXphi_pIII-N1 PF16710.5 ORX60503.1 - 0.18 11.9 1.0 25 5.0 0.0 3.0 2 1 1 3 3 3 0 N-terminal N1 domain of Vibrio phage CTXphi pIII zf-C2H2_2 PF12756.7 ORX60504.1 - 1.5e-35 121.5 10.3 1.8e-29 102.0 0.5 3.2 2 1 1 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX60504.1 - 4.3e-08 33.2 2.6 4.3e-08 33.2 2.6 3.8 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX60504.1 - 1.2e-06 28.7 2.8 1.2e-06 28.7 2.8 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 ORX60504.1 - 0.008 16.1 0.3 0.058 13.3 0.1 2.6 2 0 0 2 2 2 1 zinc-finger of a C2HC-type zf-C2H2_4 PF13894.6 ORX60504.1 - 0.017 16.0 0.3 0.017 16.0 0.3 5.1 5 0 0 5 5 5 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ORX60504.1 - 0.02 15.3 1.0 0.02 15.3 1.0 4.7 5 1 0 5 5 4 0 Zinc finger, C2H2 type GAPT PF11770.8 ORX60504.1 - 0.051 13.4 0.3 0.09 12.6 0.3 1.3 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) S4 PF01479.25 ORX60504.1 - 0.16 11.7 0.0 0.41 10.4 0.0 1.7 1 0 0 1 1 1 0 S4 domain zf-BED PF02892.15 ORX60504.1 - 0.31 11.1 9.2 3.8 7.6 0.9 3.6 3 0 0 3 3 3 0 BED zinc finger DUF2024 PF09630.10 ORX60504.1 - 0.42 10.5 0.1 0.42 10.5 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF2024) AKAP95 PF04988.12 ORX60504.1 - 0.46 10.7 8.2 0.98 9.6 3.9 2.5 2 1 0 2 2 2 0 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_6 PF13912.6 ORX60504.1 - 0.62 10.1 4.8 1.2 9.2 0.7 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger Transket_pyr PF02779.24 ORX60505.1 - 4.7e-47 160.0 0.2 8.1e-47 159.2 0.2 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 ORX60505.1 - 1.6e-34 118.5 0.1 4.5e-34 117.0 0.0 1.7 2 0 0 2 2 2 1 Transketolase, C-terminal domain Peptidase_C4 PF00863.19 ORX60505.1 - 0.015 14.7 0.0 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 Peptidase family C4 Alpha-amylase PF00128.24 ORX60506.1 - 1.9e-48 165.8 0.3 7.1e-48 163.9 0.3 1.9 1 1 0 1 1 1 1 Alpha amylase, catalytic domain DUF1966 PF09260.11 ORX60506.1 - 2.9e-06 27.4 0.1 6.4e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Cellulase-like PF12876.7 ORX60506.1 - 0.026 13.9 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 0 Sugar-binding cellulase-like hDGE_amylase PF14701.6 ORX60506.1 - 0.19 10.8 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Xpo1 PF08389.12 ORX60507.1 - 1e-23 84.1 4.9 2.9e-23 82.6 1.2 3.3 3 0 0 3 3 3 1 Exportin 1-like protein IBN_N PF03810.19 ORX60507.1 - 4.2e-06 26.6 2.5 4.2e-06 26.6 2.5 3.7 4 0 0 4 4 4 1 Importin-beta N-terminal domain Importin_rep PF18773.1 ORX60507.1 - 0.00034 20.3 0.1 0.00077 19.1 0.1 1.7 1 0 0 1 1 1 1 Importin 13 repeat HEAT PF02985.22 ORX60507.1 - 0.079 13.3 7.2 21 5.7 0.0 5.6 6 0 0 6 6 6 0 HEAT repeat Leg1 PF05612.12 ORX60507.1 - 0.088 11.9 0.2 1.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Leg1 PAPS_reduct PF01507.19 ORX60508.1 - 1.6e-29 103.1 0.0 6.9e-20 71.8 0.0 2.2 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family DUF1612 PF07756.12 ORX60510.1 - 0.00056 20.2 0.4 0.09 13.0 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1612) DUF728 PF05304.12 ORX60510.1 - 0.14 12.0 4.0 0.3 10.9 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF728) DUF1644 PF07800.12 ORX60511.1 - 0.0011 19.0 3.6 0.0012 18.9 1.1 2.0 2 1 0 2 2 2 1 Protein of unknown function (DUF1644) CwsA PF10814.8 ORX60511.1 - 0.19 11.9 8.7 0.93 9.7 1.6 2.3 2 0 0 2 2 2 0 Cell wall synthesis protein CwsA HD PF01966.22 ORX60512.1 - 5.4e-08 33.1 0.0 1e-07 32.2 0.0 1.5 1 0 0 1 1 1 1 HD domain HD_4 PF13328.6 ORX60512.1 - 0.00045 20.0 0.3 0.001 18.8 0.3 1.7 1 1 0 1 1 1 1 HD domain HDOD PF08668.12 ORX60512.1 - 0.0094 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 HDOD domain MIOX PF05153.15 ORX60512.1 - 0.055 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Myo-inositol oxygenase PhyH PF05721.13 ORX60513.1 - 6.6e-30 104.9 0.0 8.5e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_3 PF13640.6 ORX60513.1 - 0.00089 20.1 0.1 0.0074 17.1 0.0 2.1 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ORX60513.1 - 0.00099 19.5 0.0 0.0022 18.4 0.0 1.6 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Integrase_H2C2 PF17921.1 ORX60514.1 - 7.6e-08 32.4 0.7 7.6e-08 32.4 0.7 2.3 3 0 0 3 3 3 1 Integrase zinc binding domain zf-H2C2 PF09337.10 ORX60514.1 - 0.0073 16.5 0.5 0.024 14.9 0.1 2.1 2 0 0 2 2 2 1 H2C2 zinc finger CotH PF08757.11 ORX60515.1 - 1.4e-32 113.5 0.4 2.1e-32 112.9 0.4 1.1 1 0 0 1 1 1 1 CotH kinase protein CotH PF08757.11 ORX60516.1 - 1.7e-33 116.5 0.3 2.8e-33 115.8 0.3 1.2 1 0 0 1 1 1 1 CotH kinase protein MMR_HSR1 PF01926.23 ORX60517.1 - 4.1e-15 55.9 0.0 2.1e-14 53.6 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ORX60517.1 - 1.7e-06 28.0 0.0 2.8e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 ORX60517.1 - 3.7e-06 26.6 0.0 0.00012 21.6 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B IIGP PF05049.13 ORX60517.1 - 1.7e-05 24.1 0.0 2.7e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 ORX60517.1 - 0.0013 19.1 0.1 0.082 13.3 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain AIG1 PF04548.16 ORX60517.1 - 0.0013 18.1 0.1 0.0023 17.3 0.1 1.3 1 0 0 1 1 1 1 AIG1 family Dynamin_N PF00350.23 ORX60517.1 - 0.0049 16.9 0.4 0.63 10.1 0.1 2.5 1 1 1 2 2 2 1 Dynamin family PduV-EutP PF10662.9 ORX60517.1 - 0.027 14.2 0.0 3.6 7.3 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 ORX60517.1 - 0.034 13.7 0.1 5.7 6.4 0.0 3.0 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Roc PF08477.13 ORX60517.1 - 0.12 12.6 0.0 0.77 10.0 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RabGAP-TBC PF00566.18 ORX60518.1 - 3.1e-36 125.0 0.0 7.8e-36 123.8 0.0 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Elongin_A PF06881.11 ORX60518.1 - 0.028 14.9 0.4 0.052 14.1 0.4 1.4 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A OrfB_Zn_ribbon PF07282.11 ORX60520.1 - 0.01 15.8 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 ORX60520.1 - 0.074 12.6 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding CPSF_A PF03178.15 ORX60521.1 - 2.7e-20 73.0 0.0 1.1e-19 70.9 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region PQQ_2 PF13360.6 ORX60521.1 - 0.0019 17.9 0.0 0.0043 16.7 0.0 1.7 1 1 0 1 1 1 1 PQQ-like domain WD40_like PF17005.5 ORX60521.1 - 0.068 12.5 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 WD40-like domain MMS1_N PF10433.9 ORX60522.1 - 2.1e-15 56.4 0.1 2.5e-15 56.1 0.1 1.0 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term TFIIB PF00382.19 ORX60523.1 - 2.1e-31 107.7 0.4 2.4e-16 59.5 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 ORX60523.1 - 1.5e-23 83.1 4.4 2.1e-22 79.4 2.5 2.6 2 0 0 2 2 2 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 ORX60523.1 - 5.3e-10 38.7 0.8 1.4e-09 37.3 0.8 1.8 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 ORX60523.1 - 0.011 15.5 0.1 2.6 7.8 0.0 2.5 2 0 0 2 2 2 0 Cyclin, N-terminal domain GatB_Yqey PF02637.18 ORX60523.1 - 0.03 14.2 2.3 0.059 13.3 0.2 2.5 2 0 0 2 2 2 0 GatB domain OrfB_Zn_ribbon PF07282.11 ORX60523.1 - 0.28 11.1 0.8 0.67 9.9 0.8 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-RRN7 PF11781.8 ORX60523.1 - 4 7.2 7.9 0.11 12.2 1.4 1.9 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 BORCS6 PF10157.9 ORX60526.1 - 0.048 13.9 0.1 0.051 13.8 0.1 1.1 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 WD40 PF00400.32 ORX60527.1 - 7.9e-33 112.0 15.1 9.7e-06 26.2 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX60527.1 - 7.3e-05 23.0 0.6 0.6 10.4 0.0 3.3 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1921 PF09081.10 ORX60527.1 - 0.0011 19.2 0.0 4.3 7.6 0.0 3.7 3 0 0 3 3 3 2 Domain of unknown function (DUF1921) Nup160 PF11715.8 ORX60527.1 - 0.017 13.8 6.0 0.1 11.2 0.2 3.2 1 1 3 4 4 4 0 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ORX60527.1 - 0.039 14.0 0.3 21 5.2 0.0 3.4 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region VCBS PF13517.6 ORX60527.1 - 0.31 11.7 2.0 24 5.6 0.0 3.8 4 1 1 5 5 5 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella zf-RanBP PF00641.18 ORX60528.1 - 7.4e-23 79.5 27.0 8.3e-08 31.4 5.1 3.4 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others RNase_T PF00929.24 ORX60528.1 - 1.6e-07 32.0 0.1 2.8e-07 31.2 0.1 1.4 1 0 0 1 1 1 1 Exonuclease RRM_1 PF00076.22 ORX60528.1 - 2.7e-06 27.1 0.0 7.3e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_ligase_ZBD PF03119.16 ORX60528.1 - 0.08 13.0 2.6 5.8 7.0 0.3 2.8 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain DZR PF12773.7 ORX60528.1 - 1.1 9.4 17.5 1.2 9.3 1.7 3.5 3 0 0 3 3 3 0 Double zinc ribbon UIM PF02809.20 ORX60529.1 - 1.2 9.2 5.5 2.2 8.4 0.7 3.0 2 0 0 2 2 2 0 Ubiquitin interaction motif GATA PF00320.27 ORX60530.1 - 3.1e-31 106.7 13.4 1.8e-15 56.2 3.4 2.5 2 0 0 2 2 2 2 GATA zinc finger DUF1752 PF08550.10 ORX60530.1 - 8.5e-12 44.7 1.2 2e-11 43.5 1.2 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Zn-ribbon_8 PF09723.10 ORX60530.1 - 0.00021 21.3 1.9 0.46 10.7 0.1 2.4 2 0 0 2 2 2 2 Zinc ribbon domain DZR PF12773.7 ORX60530.1 - 0.0049 16.9 5.5 0.12 12.4 6.3 2.8 1 1 2 3 3 3 2 Double zinc ribbon Auto_anti-p27 PF06677.12 ORX60530.1 - 0.012 15.7 4.8 0.46 10.7 0.4 2.4 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) OrfB_Zn_ribbon PF07282.11 ORX60530.1 - 0.014 15.3 5.6 0.035 14.0 1.1 2.6 2 0 0 2 2 2 0 Putative transposase DNA-binding domain OTT_1508_deam PF14441.6 ORX60530.1 - 0.094 12.7 0.5 13 5.9 0.0 2.6 2 0 0 2 2 2 0 OTT_1508-like deaminase TF_Zn_Ribbon PF08271.12 ORX60530.1 - 0.16 11.5 9.3 1.8 8.1 0.6 3.1 2 1 1 3 3 3 0 TFIIB zinc-binding eIF-5_eIF-2B PF01873.17 ORX60530.1 - 0.76 9.7 4.7 8.6 6.3 0.4 2.5 2 0 0 2 2 2 0 Domain found in IF2B/IF5 ZF-HD_dimer PF04770.12 ORX60530.1 - 4.2 7.8 4.9 29 5.1 1.1 3.0 3 1 0 3 3 3 0 ZF-HD protein dimerisation region Nudix_N_2 PF14803.6 ORX60530.1 - 4.3 7.3 5.3 19 5.3 0.4 3.0 2 2 0 2 2 2 0 Nudix N-terminal TRAM_LAG1_CLN8 PF03798.16 ORX60531.1 - 7.4e-35 120.5 28.3 7.4e-35 120.5 28.3 2.0 2 0 0 2 2 2 1 TLC domain zf-C2H2 PF00096.26 ORX60532.1 - 4.9e-05 23.5 19.1 0.033 14.6 7.3 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 ORX60532.1 - 0.00037 20.2 2.0 0.00037 20.2 2.0 2.5 2 0 0 2 2 2 1 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 ORX60532.1 - 0.0028 18.4 16.7 0.024 15.5 4.7 2.7 3 0 0 3 3 2 2 C2H2-type zinc finger Zn_Tnp_IS1595 PF12760.7 ORX60532.1 - 0.01 15.8 3.7 0.015 15.2 3.7 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-SNAP50_C PF12251.8 ORX60532.1 - 0.011 15.4 3.3 0.017 14.8 3.3 1.2 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Zn-ribbon_8 PF09723.10 ORX60532.1 - 0.024 14.8 2.3 4.3 7.6 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 ORX60532.1 - 0.028 14.8 2.2 0.028 14.8 2.2 3.3 2 1 1 3 3 3 0 Zinc-finger double domain Mut7-C PF01927.16 ORX60532.1 - 0.038 14.1 0.3 0.053 13.6 0.3 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain zf-MYST PF17772.1 ORX60532.1 - 0.046 13.3 0.9 0.5 10.0 0.1 2.4 2 0 0 2 2 2 0 MYST family zinc finger domain zf-C2H2_jaz PF12171.8 ORX60532.1 - 0.15 12.4 11.4 0.5 10.7 3.5 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX60532.1 - 0.15 12.1 10.6 1.5 9.0 5.2 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-CHY PF05495.12 ORX60532.1 - 1.5 9.4 13.0 4.2 7.9 8.9 2.2 1 1 1 2 2 2 0 CHY zinc finger OrfB_Zn_ribbon PF07282.11 ORX60532.1 - 1.6 8.7 5.4 2.7 8.0 0.8 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-C2HE PF16278.5 ORX60532.1 - 7.4 7.1 13.3 14 6.3 3.8 2.5 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger G6PD_C PF02781.16 ORX60533.1 - 3.8e-110 367.7 0.0 5.1e-110 367.2 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ORX60533.1 - 1.1e-58 198.8 0.0 2e-58 197.9 0.0 1.4 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain SANT_DAMP1_like PF16282.5 ORX60535.1 - 1.3e-28 99.0 2.0 2.6e-28 98.0 2.0 1.6 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 ORX60535.1 - 8.6e-05 22.5 11.9 0.00018 21.4 11.9 1.6 1 1 0 1 1 1 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-bind_6 PF13921.6 ORX60535.1 - 0.00034 20.8 0.1 0.00092 19.4 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ORX60535.1 - 0.001 19.2 0.0 0.0028 17.8 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Draxin PF15550.6 ORX60535.1 - 1.6 8.6 10.6 2.2 8.1 10.6 1.3 1 0 0 1 1 1 0 Draxin DUF4407 PF14362.6 ORX60535.1 - 1.8 7.9 9.0 2.6 7.3 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec39 PF08314.11 ORX60536.1 - 4.6e-87 293.2 0.0 1e-86 292.1 0.0 1.5 1 1 0 1 1 1 1 Secretory pathway protein Sec39 PQQ_2 PF13360.6 ORX60536.1 - 0.011 15.3 0.1 0.021 14.4 0.1 1.3 1 0 0 1 1 1 0 PQQ-like domain Peptidase_C23 PF05379.11 ORX60536.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.6 1 0 0 1 1 1 0 Carlavirus endopeptidase tRNA-synt_1 PF00133.22 ORX60537.1 - 6.3e-217 721.6 0.0 7.3e-216 718.1 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX60537.1 - 5.6e-33 114.1 0.0 1.3e-32 112.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX60537.1 - 5.8e-14 51.6 0.0 1.6e-06 27.2 0.0 4.3 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ORX60537.1 - 2.3e-07 30.5 7.0 1.1e-06 28.3 0.1 2.9 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 ORX60537.1 - 0.11 11.8 2.6 0.29 10.4 0.0 2.7 4 0 0 4 4 4 0 tRNA synthetases class I (C) catalytic domain PepSY PF03413.19 ORX60537.1 - 0.64 10.6 0.0 0.64 10.6 0.0 2.6 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain tRNA-synt_1b PF00579.25 ORX60537.1 - 1.4 8.2 3.3 2.1 7.6 0.0 2.4 3 0 0 3 3 3 0 tRNA synthetases class I (W and Y) PIP5K PF01504.18 ORX60538.1 - 1.9e-98 329.1 0.9 3e-98 328.4 0.9 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PEMT PF04191.13 ORX60539.1 - 1.2e-56 189.6 10.6 3.7e-34 117.3 0.8 2.8 2 0 0 2 2 2 2 Phospholipid methyltransferase SKICH PF17751.1 ORX60539.1 - 0.0053 17.3 0.0 1.1 9.9 0.1 2.5 2 0 0 2 2 2 1 SKICH domain HECW_N PF16562.5 ORX60539.1 - 0.0055 16.5 1.4 0.013 15.3 0.4 2.0 2 0 0 2 2 2 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 Tetraspanin PF00335.20 ORX60539.1 - 0.061 13.0 0.5 3.9 7.1 0.0 2.6 2 0 0 2 2 2 0 Tetraspanin family Peptidase_M3 PF01432.20 ORX60539.1 - 0.079 12.2 1.7 0.13 11.5 1.7 1.2 1 0 0 1 1 1 0 Peptidase family M3 RIO1 PF01163.22 ORX60539.1 - 0.08 12.5 1.8 0.17 11.5 1.8 1.5 1 0 0 1 1 1 0 RIO1 family Methyltransf_25 PF13649.6 ORX60540.1 - 1.3e-06 29.0 0.0 2.7e-06 28.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX60540.1 - 9.4e-06 26.2 0.0 2.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX60540.1 - 0.003 17.4 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX60540.1 - 0.012 16.3 0.0 0.02 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ORX60540.1 - 0.041 13.2 0.0 0.06 12.7 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family AIG1 PF04548.16 ORX60542.1 - 1.9e-19 69.8 0.0 3.6e-19 68.9 0.0 1.4 1 1 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ORX60542.1 - 9.6e-10 38.5 0.0 1.5e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ORX60542.1 - 2.3e-07 31.0 0.7 0.00048 20.2 0.7 2.5 2 0 0 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 ORX60542.1 - 0.001 19.0 0.4 0.0032 17.4 0.2 1.9 2 1 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 ORX60542.1 - 0.0012 18.4 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GBP PF02263.19 ORX60542.1 - 0.0055 16.0 0.0 0.0094 15.2 0.0 1.4 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain ABC_tran PF00005.27 ORX60542.1 - 0.09 13.3 0.5 0.12 12.9 0.4 1.6 1 1 0 1 1 1 0 ABC transporter Roc PF08477.13 ORX60542.1 - 0.21 11.8 1.0 1 9.6 0.1 2.4 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SPX PF03105.19 ORX60543.1 - 1.5e-33 117.3 19.3 3.2e-17 63.6 15.4 3.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 ORX60543.1 - 7.7e-21 74.7 36.5 1.2e-20 74.1 36.5 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 ORX60543.1 - 9.2e-17 61.2 39.9 9.2e-17 61.2 39.9 1.8 1 1 0 1 1 1 1 Citrate transporter MFS_MOT1 PF16983.5 ORX60544.1 - 6.8e-57 190.7 36.3 7.2e-31 106.9 6.1 3.7 4 0 0 4 4 4 2 Molybdate transporter of MFS superfamily DUF5362 PF17319.2 ORX60544.1 - 0.81 9.6 5.6 0.62 9.9 1.2 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5362) DUF543 PF04418.12 ORX60544.1 - 1.2 9.2 3.3 8 6.5 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF543) LRR_4 PF12799.7 ORX60545.1 - 4.3e-08 33.3 22.0 0.028 14.8 0.3 7.5 6 3 3 9 9 9 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX60545.1 - 0.0011 18.9 24.0 1.5 9.0 0.2 8.4 10 0 0 10 10 10 3 Leucine Rich repeat LRR_1 PF00560.33 ORX60545.1 - 0.008 16.6 13.5 15 6.6 0.0 7.7 9 1 0 9 9 9 1 Leucine Rich Repeat LRR_8 PF13855.6 ORX60545.1 - 0.015 15.1 22.2 2.1 8.2 0.2 6.7 5 3 0 6 6 6 0 Leucine rich repeat LRR_9 PF14580.6 ORX60545.1 - 0.08 12.4 0.2 1 8.9 0.0 2.6 2 1 1 3 3 3 0 Leucine-rich repeat DUF3322 PF11795.8 ORX60545.1 - 0.14 12.1 3.6 0.37 10.8 0.3 2.7 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) Sec2p PF06428.11 ORX60546.1 - 1.1e-22 79.8 14.6 1.1e-22 79.8 14.6 2.5 2 0 0 2 2 2 2 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 ORX60546.1 - 0.0035 17.6 6.1 0.0035 17.6 6.1 2.8 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.19 ORX60546.1 - 0.36 8.7 15.9 0.042 11.8 11.4 1.6 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family CdvA PF18822.1 ORX60546.1 - 0.74 9.6 21.6 1.1 9.1 9.0 2.7 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Fib_alpha PF08702.10 ORX60546.1 - 6.6 6.9 17.2 0.9 9.7 6.5 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF1772 PF08592.11 ORX60547.1 - 1.6e-14 54.4 1.6 2.5e-14 53.7 1.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Nbl1_Borealin_N PF10444.9 ORX60547.1 - 0.00062 19.3 0.2 0.0011 18.5 0.2 1.4 1 0 0 1 1 1 1 Nbl1 / Borealin N terminal Sec2p PF06428.11 ORX60548.1 - 8.9e-12 44.8 4.7 8.9e-12 44.8 4.7 2.5 2 1 1 3 3 3 1 GDP/GTP exchange factor Sec2p Fungal_trans PF04082.18 ORX60549.1 - 4.7e-06 25.8 0.0 1.2e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain DUF5082 PF16888.5 ORX60549.1 - 0.016 15.5 0.3 7.2 6.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) CLZ PF16526.5 ORX60549.1 - 0.018 15.4 0.1 0.055 13.8 0.1 1.8 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Bcr-Abl_Oligo PF09036.10 ORX60549.1 - 0.16 12.0 0.0 0.9 9.6 0.0 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain HisKA_3 PF07730.13 ORX60549.1 - 0.17 12.5 7.2 0.22 12.1 0.3 2.5 2 0 0 2 2 2 0 Histidine kinase GATA PF00320.27 ORX60550.1 - 1.3e-17 63.1 2.6 1.7e-17 62.7 2.6 1.2 1 0 0 1 1 1 1 GATA zinc finger PDCD2_C PF04194.13 ORX60551.1 - 9.1e-37 126.8 1.8 7.4e-36 123.8 0.0 2.6 2 1 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain zf-MYND PF01753.18 ORX60551.1 - 1.2e-06 28.5 12.4 1.2e-06 28.5 12.4 3.1 3 0 0 3 3 3 1 MYND finger RRM_1 PF00076.22 ORX60552.1 - 1.6e-05 24.7 0.6 3.6e-05 23.5 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PVL_ORF50 PF07768.11 ORX60552.1 - 0.01 16.2 0.5 0.02 15.2 0.5 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family DAPG_hydrolase PF18089.1 ORX60552.1 - 0.014 14.9 0.6 0.037 13.6 0.6 1.6 1 1 0 1 1 1 0 DAPG hydrolase PhiG domain TQ PF18202.1 ORX60552.1 - 0.39 11.3 9.6 0.47 11.0 6.7 2.2 1 1 1 2 2 2 0 T-Q ester bond containing domain Sec23_trunk PF04811.15 ORX60553.1 - 3e-65 220.2 0.0 4.6e-65 219.6 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ORX60553.1 - 3.9e-25 87.7 0.0 7.9e-25 86.7 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 ORX60553.1 - 2.5e-18 66.6 0.0 6.8e-18 65.2 0.0 1.8 2 0 0 2 2 2 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ORX60553.1 - 1.8e-14 53.5 6.2 3.4e-14 52.6 6.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX60553.1 - 8.6e-09 35.2 0.0 2.3e-08 33.8 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Ribosomal_L27A PF00828.19 ORX60556.1 - 3.5e-21 76.2 0.3 4.4e-21 75.9 0.1 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A WD40 PF00400.32 ORX60557.1 - 1.4e-52 174.5 13.8 4.6e-10 39.9 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ORX60557.1 - 1.2e-39 135.5 5.4 2.2e-39 134.6 5.4 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ORX60557.1 - 2.9e-09 37.1 0.0 0.21 11.9 0.0 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX60557.1 - 9.9e-07 27.8 0.5 0.01 14.5 0.0 3.5 2 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX60557.1 - 0.00011 21.6 0.0 0.07 12.4 0.0 3.5 3 1 0 3 3 3 1 WD40-like domain VID27 PF08553.10 ORX60557.1 - 0.016 14.3 0.0 0.03 13.4 0.0 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain LisH PF08513.11 ORX60557.1 - 1.2 9.2 5.4 1.9 8.5 0.1 3.3 3 0 0 3 3 3 0 LisH P21-Arc PF04062.14 ORX60559.1 - 3.8e-78 261.5 0.0 4.2e-78 261.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit Hormone_3 PF00159.18 ORX60559.1 - 0.18 11.9 0.0 0.33 11.0 0.0 1.5 1 0 0 1 1 1 0 Pancreatic hormone peptide Opi1 PF08618.10 ORX60561.1 - 3.5e-46 158.3 5.8 1.3e-37 130.1 2.3 2.1 1 1 1 2 2 2 2 Transcription factor Opi1 Sgf11 PF08209.11 ORX60562.1 - 5.1e-13 48.3 0.3 5.1e-13 48.3 0.3 2.3 2 0 0 2 2 2 1 Sgf11 (transcriptional regulation protein) DSPc PF00782.20 ORX60563.1 - 1.4e-05 24.9 0.0 1.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX60563.1 - 0.0021 17.6 0.0 0.0033 17.0 0.0 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 ORX60563.1 - 0.012 15.2 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ORX60564.1 - 2.1e-54 183.5 0.0 2.3e-54 183.4 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX60564.1 - 0.00025 21.1 0.0 0.00084 19.4 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX60564.1 - 0.013 15.1 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase CPSF_A PF03178.15 ORX60565.1 - 5.9e-86 288.7 0.1 1.4e-85 287.5 0.1 1.6 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ORX60565.1 - 2.8e-36 125.2 0.3 8.7e-36 123.6 0.3 1.9 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Ribosomal_S28e PF01200.18 ORX60566.1 - 8e-34 115.4 0.9 9e-34 115.3 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Phostensin_N PF13916.6 ORX60566.1 - 0.057 13.8 0.0 0.061 13.7 0.0 1.1 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal IF-2B PF01008.17 ORX60567.1 - 8.5e-72 241.7 1.3 9.8e-72 241.5 1.3 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family TFIIS_M PF07500.14 ORX60568.1 - 4e-23 82.0 0.1 7.9e-23 81.1 0.1 1.5 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 ORX60568.1 - 4.3e-12 46.2 0.0 1.1e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 SPOC domain DUF5102 PF17104.5 ORX60568.1 - 2 8.4 10.8 0.019 15.0 2.6 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5102) PH_9 PF15410.6 ORX60569.1 - 1.8e-08 34.7 0.3 3e-08 34.0 0.3 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX60569.1 - 8.2e-08 32.7 0.3 1.2e-07 32.1 0.3 1.3 1 0 0 1 1 1 1 PH domain MIP PF00230.20 ORX60570.1 - 1.4e-33 116.5 15.7 2.6e-33 115.6 8.1 2.0 1 1 1 2 2 2 2 Major intrinsic protein DUF3169 PF11368.8 ORX60570.1 - 0.8 9.2 7.7 0.44 10.0 2.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) CBFD_NFYB_HMF PF00808.23 ORX60571.1 - 1.6e-18 66.7 0.4 2.3e-18 66.2 0.4 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-W PF15510.6 ORX60571.1 - 0.1 12.8 0.2 0.17 12.1 0.2 1.3 1 0 0 1 1 1 0 CENP-W protein Suc_Fer-like PF06999.12 ORX60572.1 - 3.2e-38 131.6 0.0 4.1e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like PigN PF04987.14 ORX60573.1 - 0.017 14.0 0.1 0.019 13.8 0.1 1.0 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) NicO PF03824.16 ORX60573.1 - 0.032 13.6 0.0 0.035 13.4 0.0 1.0 1 0 0 1 1 1 0 High-affinity nickel-transport protein ETRAMP PF09716.10 ORX60573.1 - 0.06 13.4 0.0 0.084 12.9 0.0 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) 7tm_1 PF00001.21 ORX60573.1 - 0.14 11.5 0.0 0.15 11.3 0.0 1.0 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Myb_DNA-bind_4 PF13837.6 ORX60574.1 - 0.0003 21.1 0.7 0.001 19.4 0.1 2.1 2 0 0 2 2 2 1 Myb/SANT-like DNA-binding domain Calici_MSP PF05752.11 ORX60574.1 - 0.43 10.4 3.0 0.68 9.7 0.1 2.3 2 0 0 2 2 2 0 Calicivirus minor structural protein SAGA-Tad1 PF12767.7 ORX60576.1 - 0.02 14.6 0.3 0.022 14.5 0.3 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Zn_ribbon_SprT PF17283.2 ORX60576.1 - 0.16 11.9 2.5 0.29 11.1 2.5 1.4 1 0 0 1 1 1 0 SprT-like zinc ribbon domain SAMP PF05924.11 ORX60576.1 - 0.21 10.9 1.2 0.41 10.0 1.2 1.5 1 0 0 1 1 1 0 SAMP Motif FxsA PF04186.13 ORX60577.1 - 0.0045 17.1 0.0 0.005 16.9 0.0 1.0 1 0 0 1 1 1 1 FxsA cytoplasmic membrane protein tRNA_anti-like PF12869.7 ORX60577.1 - 0.075 12.7 0.0 0.078 12.6 0.0 1.0 1 0 0 1 1 1 0 tRNA_anti-like Serinc PF03348.15 ORX60577.1 - 0.24 10.3 0.0 0.24 10.3 0.0 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Glyco_hydro_9 PF00759.19 ORX60578.1 - 1.1e-92 311.6 22.0 1.1e-92 311.6 22.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 9 zf-C3HC4_3 PF13920.6 ORX60579.1 - 3e-08 33.4 5.0 5.8e-08 32.5 5.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX60579.1 - 4.2e-08 32.9 8.0 8.4e-08 32.0 8.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX60579.1 - 1.2e-07 31.9 8.5 4.3e-07 30.2 8.6 1.9 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX60579.1 - 6.5e-07 29.1 6.8 8.7e-06 25.5 8.0 2.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX60579.1 - 1.2e-06 28.3 6.3 2.3e-06 27.5 6.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ORX60579.1 - 6.4e-06 26.1 5.8 6.4e-06 26.1 5.8 2.2 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ORX60579.1 - 0.00052 19.8 5.5 0.0014 18.5 5.4 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Spem1 PF15670.5 ORX60579.1 - 0.0018 17.9 2.3 0.0018 17.9 2.3 2.7 3 0 0 3 3 3 1 Spermatid maturation protein 1 DUF3752 PF12572.8 ORX60579.1 - 0.0021 18.6 3.7 0.0021 18.6 3.7 2.1 3 0 0 3 3 1 1 Protein of unknown function (DUF3752) zf-C3HC4_4 PF15227.6 ORX60579.1 - 0.0053 16.9 8.5 0.013 15.6 8.5 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-MIZ PF02891.20 ORX60579.1 - 0.0075 16.0 10.5 0.029 14.1 10.6 2.0 1 1 1 2 2 2 1 MIZ/SP-RING zinc finger FYVE PF01363.21 ORX60579.1 - 0.012 15.7 0.8 0.031 14.4 0.8 1.6 1 0 0 1 1 1 0 FYVE zinc finger zf-ANAPC11 PF12861.7 ORX60579.1 - 0.017 15.2 1.6 0.033 14.2 1.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-Nse PF11789.8 ORX60579.1 - 0.021 14.7 1.7 0.056 13.3 1.7 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 ORX60579.1 - 0.069 13.5 6.0 0.18 12.1 6.0 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain TerY_C PF15616.6 ORX60579.1 - 0.078 13.1 0.5 0.22 11.6 0.5 1.7 1 0 0 1 1 1 0 TerY-C metal binding domain zf-ACC PF17848.1 ORX60579.1 - 0.17 12.0 0.6 0.47 10.6 0.6 1.8 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain zf-RING_11 PF17123.5 ORX60579.1 - 4.1 7.3 9.8 1.5 8.6 4.4 2.8 3 0 0 3 3 3 0 RING-like zinc finger Ysc84 PF04366.12 ORX60580.1 - 1.4e-44 150.9 1.0 2.4e-44 150.2 0.6 1.6 2 0 0 2 2 2 1 Las17-binding protein actin regulator SH3_1 PF00018.28 ORX60580.1 - 7e-14 51.2 0.2 1.6e-13 50.0 0.1 1.7 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ORX60580.1 - 2.4e-12 46.5 0.0 4.3e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ORX60580.1 - 2.1e-09 36.9 0.0 4.4e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Acyl-CoA_dh_1 PF00441.24 ORX60581.1 - 5.7e-34 117.5 0.3 8.7e-34 116.9 0.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ORX60581.1 - 3.1e-22 78.6 0.0 7.2e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX60581.1 - 2.7e-15 56.8 1.1 4.7e-15 56.0 1.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX60581.1 - 3.5e-13 50.2 0.0 6.1e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain HpaB_N PF11794.8 ORX60581.1 - 0.0015 18.2 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Sec8_exocyst PF04048.14 ORX60581.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain Reticulon PF02453.17 ORX60583.1 - 2.5e-22 79.5 1.9 3.2e-22 79.2 1.9 1.1 1 0 0 1 1 1 1 Reticulon DUF639 PF04842.12 ORX60583.1 - 0.0035 16.8 0.4 0.0049 16.3 0.4 1.3 1 0 0 1 1 1 1 Plant protein of unknown function (DUF639) SQS_PSY PF00494.19 ORX60583.1 - 0.013 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Squalene/phytoene synthase DUF4491 PF14898.6 ORX60583.1 - 0.033 14.6 1.4 0.057 13.9 0.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4491) Lactamase_B_4 PF13691.6 ORX60584.1 - 1.5e-16 59.8 0.0 4.2e-16 58.4 0.0 1.8 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 ORX60584.1 - 2.5e-14 53.3 0.4 8.6e-14 51.5 0.4 2.0 2 0 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ORX60584.1 - 1.4e-05 25.2 0.1 3e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily PTPlike_phytase PF14566.6 ORX60585.1 - 5.4e-140 461.9 0.2 1.1e-46 158.8 0.1 3.9 4 0 0 4 4 4 3 Inositol hexakisphosphate DSPc PF00782.20 ORX60585.1 - 4.1e-06 26.6 0.0 0.0071 16.2 0.0 3.1 3 0 0 3 3 3 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX60585.1 - 0.00012 21.7 0.0 1.3 8.5 0.0 3.2 3 0 0 3 3 3 2 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ORX60585.1 - 0.041 13.9 0.0 15 5.5 0.0 3.4 3 0 0 3 3 3 0 Tyrosine phosphatase family Cob_adeno_trans PF01923.18 ORX60586.1 - 0.092 12.9 1.3 0.22 11.7 1.3 1.6 1 0 0 1 1 1 0 Cobalamin adenosyltransferase His_kinase PF06580.13 ORX60586.1 - 0.11 12.8 1.6 0.39 11.1 0.3 2.3 1 1 1 2 2 2 0 Histidine kinase Spc29 PF17082.5 ORX60586.1 - 0.17 11.7 7.9 0.047 13.5 3.8 2.0 1 1 0 2 2 2 0 Spindle Pole Component 29 DUF1664 PF07889.12 ORX60586.1 - 0.73 9.9 5.9 0.15 12.1 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HMMR_N PF15905.5 ORX60586.1 - 5 6.5 17.1 42 3.5 17.1 2.2 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Tropomyosin_1 PF12718.7 ORX60586.1 - 8 6.6 17.7 0.62 10.2 8.8 2.5 2 0 0 2 2 2 0 Tropomyosin like CS PF04969.16 ORX60587.1 - 0.0018 19.2 1.0 0.0088 17.0 0.7 2.1 3 0 0 3 3 3 1 CS domain DUF1192 PF06698.11 ORX60588.1 - 6.1 7.0 6.2 5.3 7.2 1.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) GREB1 PF15782.5 ORX60588.1 - 8.4 3.4 12.6 12 2.8 12.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ATP-synt_ab PF00006.25 ORX60589.1 - 4e-53 180.2 0.0 8.3e-53 179.2 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX60589.1 - 1.6e-23 83.0 2.4 3.8e-23 81.8 2.0 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain NACHT PF05729.12 ORX60589.1 - 0.0086 16.0 0.1 0.02 14.8 0.0 1.6 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ORX60589.1 - 0.011 14.9 1.0 0.015 14.5 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain ATPase_2 PF01637.18 ORX60589.1 - 0.012 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ORX60589.1 - 0.019 15.4 0.1 0.065 13.6 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX60589.1 - 0.024 15.1 0.0 0.35 11.3 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ORX60589.1 - 0.029 14.3 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 ORX60589.1 - 0.033 13.5 0.1 0.063 12.6 0.1 1.5 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 ORX60589.1 - 0.052 13.4 0.6 0.35 10.7 0.6 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain RNA_helicase PF00910.22 ORX60589.1 - 0.13 12.6 0.0 0.33 11.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 ORX60589.1 - 0.36 11.2 1.9 0.3 11.4 0.2 1.7 2 0 0 2 2 2 0 AAA domain Amidohydro_3 PF07969.11 ORX60590.1 - 6.7e-26 91.8 0.5 1.1e-09 38.3 0.0 3.8 3 0 0 3 3 3 3 Amidohydrolase family Amidohydro_1 PF01979.20 ORX60590.1 - 1.8e-21 76.8 0.1 4.1e-12 46.1 0.0 3.4 3 0 0 3 3 3 3 Amidohydrolase family CUE PF02845.16 ORX60591.1 - 1e-07 31.5 0.0 1.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain FUN14 PF04930.15 ORX60593.1 - 1.5e-23 83.0 3.4 1.9e-23 82.7 3.4 1.1 1 0 0 1 1 1 1 FUN14 family M20_dimer PF07687.14 ORX60595.1 - 9.8e-09 35.1 0.0 2.1e-08 34.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ORX60595.1 - 1.4e-07 31.4 0.4 3.4e-07 30.2 0.4 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Med18 PF09637.10 ORX60596.1 - 1.7e-07 31.4 0.0 7.7e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Med18 protein Tsi6 PF18660.1 ORX60597.1 - 0.27 11.3 0.0 0.36 10.9 0.0 1.2 1 0 0 1 1 1 0 Tsi6 COA2 PF17051.5 ORX60598.1 - 1.1e-06 28.6 0.6 1.6e-06 28.1 0.6 1.3 1 1 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 DUF2099 PF09872.9 ORX60598.1 - 0.091 11.9 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2099) PIEZO PF15917.5 ORX60599.1 - 1 8.8 5.1 2 7.9 5.1 1.4 1 0 0 1 1 1 0 Piezo NDK PF00334.19 ORX60600.1 - 2.1e-40 137.8 0.0 3.6e-40 137.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoside diphosphate kinase RhoGEF PF00621.20 ORX60601.1 - 5.1e-36 124.6 6.9 9.3e-36 123.8 6.9 1.5 1 0 0 1 1 1 1 RhoGEF domain CDC24 PF06395.11 ORX60601.1 - 4.4e-35 119.8 0.0 9.5e-35 118.7 0.0 1.6 1 0 0 1 1 1 1 CDC24 Calponin PH_10 PF15411.6 ORX60601.1 - 1e-23 83.9 1.0 2.2e-23 82.9 1.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 ORX60601.1 - 2.8e-16 59.2 0.2 9.7e-16 57.5 0.2 2.0 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 ORX60601.1 - 0.0082 16.6 0.3 0.024 15.1 0.3 1.8 1 0 0 1 1 1 1 PH domain Glyco_hydro_16 PF00722.21 ORX60603.1 - 1.2e-09 37.9 0.0 3.4e-09 36.4 0.0 1.7 1 1 1 2 2 2 1 Glycosyl hydrolases family 16 GPS PF01825.21 ORX60603.1 - 1.6 9.3 6.0 30 5.2 1.0 3.1 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif MFS_1 PF07690.16 ORX60604.1 - 3.3e-45 154.6 29.7 3.3e-45 154.6 29.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX60604.1 - 1e-10 41.1 7.8 1e-10 41.1 7.8 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_4 PF06779.14 ORX60604.1 - 4.9e-06 26.1 2.2 4.9e-06 26.1 2.2 2.2 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_3 PF05977.13 ORX60604.1 - 8.7e-05 21.1 0.7 0.00013 20.5 0.7 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector DUF2615 PF11027.8 ORX60604.1 - 0.14 12.3 1.5 2 8.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) Pox_A14 PF05767.12 ORX60604.1 - 5.1 7.3 8.6 0.27 11.4 1.8 2.5 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DHHC PF01529.20 ORX60605.1 - 1.5e-37 128.7 9.8 1.5e-37 128.7 9.8 2.3 2 1 0 2 2 2 1 DHHC palmitoyltransferase Spt4 PF06093.13 ORX60605.1 - 0.85 9.8 6.0 1.8 8.7 6.0 1.5 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger eIF-1a PF01176.19 ORX60607.1 - 4.3e-16 58.5 0.0 6e-16 58.0 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 TFIIS_M PF07500.14 ORX60608.1 - 2.7e-25 89.0 0.1 3.2e-25 88.8 0.1 1.1 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain LNS2 PF08235.13 ORX60609.1 - 9e-105 349.1 0.0 1.6e-104 348.3 0.0 1.4 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ORX60609.1 - 1e-40 137.8 0.1 1.7e-40 137.1 0.1 1.4 1 0 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 ORX60609.1 - 1.8e-16 60.1 0.0 4.9e-16 58.7 0.0 1.8 2 0 0 2 2 2 1 Lipin/Ned1/Smp2 multi-domain protein middle domain DUF2631 PF10939.8 ORX60609.1 - 0.14 12.0 0.3 0.3 10.9 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) adh_short PF00106.25 ORX60610.1 - 2.6e-15 56.4 0.0 9.9e-15 54.5 0.0 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX60610.1 - 1.9e-07 30.9 0.0 0.0013 18.3 0.0 2.2 1 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX60610.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 KR domain RRM_1 PF00076.22 ORX60611.1 - 3.8e-43 145.2 0.0 5.6e-17 61.3 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX60611.1 - 1.4e-05 25.0 0.0 0.00067 19.6 0.0 3.1 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ORX60611.1 - 0.00011 22.2 0.0 0.036 14.2 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif RRM_3 PF08777.11 ORX60611.1 - 0.0025 17.8 0.0 0.0068 16.4 0.0 1.6 2 0 0 2 2 2 1 RNA binding motif Herpes_ORF11 PF04797.13 ORX60611.1 - 0.0098 14.7 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 1 Herpesvirus dUTPase protein DUF3774 PF12609.8 ORX60612.1 - 0.056 14.5 5.1 0.069 14.2 5.1 1.2 1 0 0 1 1 1 0 Wound-induced protein Nic96 PF04097.14 ORX60613.1 - 1.7e-115 386.9 3.7 2.3e-115 386.4 3.7 1.2 1 0 0 1 1 1 1 Nup93/Nic96 PPP5 PF08321.12 ORX60613.1 - 0.13 12.6 0.6 1.4 9.3 0.0 3.0 2 1 0 2 2 2 0 PPP5 TPR repeat region UreD PF01774.17 ORX60614.1 - 6.3e-53 179.9 0.0 7.4e-53 179.6 0.0 1.0 1 0 0 1 1 1 1 UreD urease accessory protein SDA1 PF05285.12 ORX60615.1 - 0.022 14.2 31.6 0.029 13.8 31.6 1.1 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 ORX60615.1 - 1.2 7.9 16.6 1.6 7.5 16.6 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.11 ORX60615.1 - 7 5.0 14.9 9.3 4.6 14.9 1.3 1 0 0 1 1 1 0 Peptidase family S64 DHHC PF01529.20 ORX60616.1 - 1.6e-35 122.1 10.4 1.6e-35 122.1 10.4 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase CPSase_L_D2 PF02786.17 ORX60617.1 - 1.2e-113 377.8 0.2 1.9e-82 275.9 0.0 2.5 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain GATase PF00117.28 ORX60617.1 - 1.3e-47 162.0 0.0 1.2e-45 155.6 0.0 2.5 2 0 0 2 2 2 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 ORX60617.1 - 4.5e-47 159.1 0.0 1e-46 157.9 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain OTCace_N PF02729.21 ORX60617.1 - 5.9e-45 152.9 0.0 1.6e-44 151.5 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 ORX60617.1 - 9.4e-40 135.8 0.0 3.4e-39 134.0 0.0 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 ORX60617.1 - 4e-34 118.0 0.1 2.5e-33 115.4 0.0 2.4 3 0 0 3 3 3 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 ORX60617.1 - 2.6e-20 72.4 0.0 1.7e-19 69.8 0.0 2.5 2 0 0 2 2 2 1 MGS-like domain Dala_Dala_lig_C PF07478.13 ORX60617.1 - 1.8e-18 66.8 1.5 1e-10 41.5 0.1 3.3 3 0 0 3 3 3 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ORX60617.1 - 2.3e-14 53.3 0.1 1.1e-08 34.9 0.0 2.5 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 ORX60617.1 - 9.4e-10 38.3 0.0 0.00024 20.9 0.0 2.9 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 ORX60617.1 - 2.9e-05 24.2 0.4 0.13 12.3 0.0 2.9 3 0 0 3 3 3 2 ATP-grasp domain Peptidase_C26 PF07722.13 ORX60617.1 - 5.7e-05 23.0 0.3 0.023 14.4 0.1 2.7 1 1 1 2 2 2 2 Peptidase C26 GARS_A PF01071.19 ORX60617.1 - 0.021 14.6 0.2 0.15 11.8 0.0 2.5 3 0 0 3 3 3 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GSH-S_ATP PF02955.16 ORX60617.1 - 0.071 12.5 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Gemin7 PF11095.8 ORX60618.1 - 4.4e-19 68.1 0.0 5.5e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Gem-associated protein 7 (Gemin7) zf-C2H2_aberr PF17017.5 ORX60619.1 - 3.5e-06 27.3 5.0 0.018 15.2 0.8 2.5 1 1 1 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ORX60619.1 - 4.3e-06 26.9 11.5 0.0061 17.0 0.9 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX60619.1 - 0.0014 19.3 13.5 0.036 14.9 0.5 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX60619.1 - 0.24 11.9 13.4 0.25 11.9 0.2 3.4 3 1 0 3 3 3 0 Zinc-finger double domain zf_C2H2_ZHX PF18387.1 ORX60619.1 - 0.53 10.0 10.7 0.64 9.7 0.6 3.1 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain DUF2101 PF09874.9 ORX60620.1 - 0.012 15.3 0.1 0.013 15.2 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) MFS_1 PF07690.16 ORX60621.1 - 2.3e-08 33.4 32.8 7.7e-05 21.8 8.4 2.7 2 1 0 2 2 2 2 Major Facilitator Superfamily MEA1 PF06910.11 ORX60622.1 - 0.02 15.5 1.8 0.32 11.6 1.8 2.3 1 1 0 1 1 1 0 Male enhanced antigen 1 (MEA1) zf-C2H2 PF00096.26 ORX60623.1 - 2.4e-15 56.0 17.0 0.00022 21.5 0.1 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX60623.1 - 1.6e-10 40.9 16.2 0.01 16.6 4.1 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX60623.1 - 3.5e-08 33.5 16.6 2.3e-05 24.6 0.5 3.8 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX60623.1 - 4.8e-07 29.9 2.3 0.01 16.1 2.9 2.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX60623.1 - 0.00019 21.7 3.2 0.26 11.7 0.0 2.9 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 ORX60623.1 - 0.0016 18.4 8.4 0.061 13.4 4.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2HE PF16278.5 ORX60623.1 - 0.024 15.1 2.6 0.45 11.0 0.2 2.3 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 ORX60623.1 - 0.4 10.8 5.6 8.8 6.5 1.2 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2_2 PF12756.7 ORX60623.1 - 0.91 9.9 5.8 12 6.3 0.3 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) RRN3 PF05327.11 ORX60624.1 - 2.5e-130 435.7 1.4 2.5e-130 435.7 1.4 1.9 1 1 1 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 DUF1539 PF07560.11 ORX60624.1 - 0.02 15.0 0.0 0.089 12.9 0.0 2.1 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) CDC45 PF02724.14 ORX60624.1 - 0.51 8.6 9.1 0.64 8.2 1.5 2.1 2 0 0 2 2 2 0 CDC45-like protein GCIP PF13324.6 ORX60624.1 - 0.59 9.7 7.4 1.8 8.1 1.4 2.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Spt5_N PF11942.8 ORX60624.1 - 3.7 8.6 27.0 2.4 9.2 6.5 2.9 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal PEN-2 PF10251.9 ORX60625.1 - 0.089 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Presenilin enhancer-2 subunit of gamma secretase Lipase_3 PF01764.25 ORX60626.1 - 7.4e-34 116.7 0.1 1.1e-33 116.1 0.1 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX60626.1 - 0.00064 19.4 0.1 0.029 13.9 0.1 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF2974) Thioesterase PF00975.20 ORX60626.1 - 0.051 13.7 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Lipase_3 PF01764.25 ORX60627.1 - 9.6e-33 113.0 0.2 1.7e-32 112.2 0.2 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ORX60627.1 - 0.00054 19.6 0.1 0.0023 17.5 0.1 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Hydrolase_4 PF12146.8 ORX60627.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Lzipper-MIP1 PF14389.6 ORX60628.1 - 0.051 13.9 15.8 0.57 10.5 3.5 3.8 2 1 2 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 Dynein_C PF18199.1 ORX60628.1 - 0.085 12.1 6.4 0.18 11.0 6.4 1.5 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain bZIP_2 PF07716.15 ORX60629.1 - 3.1e-12 46.4 4.6 3.1e-12 46.4 4.6 1.8 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX60629.1 - 5e-08 32.9 9.3 7.8e-08 32.3 8.5 1.7 1 1 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX60629.1 - 0.0024 18.4 3.0 0.0039 17.7 3.0 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor SR-25 PF10500.9 ORX60629.1 - 0.18 11.4 12.7 0.31 10.6 12.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein OrfB_Zn_ribbon PF07282.11 ORX60630.1 - 8.6e-10 38.4 2.5 1.6e-09 37.5 2.5 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-SNAP50_C PF12251.8 ORX60630.1 - 0.078 12.6 0.8 0.14 11.8 0.8 1.3 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Ceramidase PF05875.12 ORX60632.1 - 2.9e-83 279.3 17.2 3.5e-83 279.0 17.2 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.11 ORX60632.1 - 0.046 13.7 0.9 0.15 12.1 0.9 1.8 1 0 0 1 1 1 0 Trp-operon Leader Peptide Sec23_trunk PF04811.15 ORX60633.1 - 4.5e-77 258.9 0.0 6.4e-77 258.4 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ORX60633.1 - 1.6e-30 105.7 0.3 3e-30 104.8 0.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ORX60633.1 - 3.2e-25 87.9 0.1 8.1e-25 86.6 0.1 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ORX60633.1 - 4.6e-16 58.6 7.0 8.8e-16 57.7 7.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX60633.1 - 6.3e-13 48.4 0.0 2.4e-12 46.6 0.0 2.0 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ORX60633.1 - 0.098 12.1 0.1 0.21 11.0 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain ECH_1 PF00378.20 ORX60634.1 - 1.2e-46 159.1 0.1 1.4e-46 158.8 0.1 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX60634.1 - 1.4e-29 103.6 0.1 2.1e-29 103.1 0.1 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SAM_2 PF07647.17 ORX60635.1 - 1.4e-06 28.3 0.0 3.1e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX60635.1 - 0.00054 20.3 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4508 PF14969.6 ORX60635.1 - 0.031 14.5 0.2 0.075 13.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) IGR PF09597.10 ORX60635.1 - 0.057 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 IGR protein motif SUIM_assoc PF16619.5 ORX60635.1 - 2.9 8.0 9.1 0.4 10.8 3.9 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L29e PF01779.17 ORX60636.1 - 4.1e-23 81.4 9.6 5.4e-23 81.0 9.6 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family Glyco_hydro_8 PF01270.17 ORX60637.1 - 9.6e-22 77.2 3.2 1.4e-21 76.7 3.2 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 8 EGF_CA PF07645.15 ORX60641.1 - 4.2e-20 71.7 16.4 0.38 11.0 0.1 9.7 10 0 0 10 10 10 9 Calcium-binding EGF domain Paxillin PF03535.13 ORX60641.1 - 2.7e-16 60.1 26.4 2.5 7.9 0.0 10.0 6 3 4 10 10 10 10 Paxillin family DUF1579 PF07617.11 ORX60641.1 - 1.1e-11 44.9 2.8 0.51 10.2 0.0 5.9 1 1 8 9 9 9 9 Protein of unknown function (DUF1579) EGF PF00008.27 ORX60641.1 - 0.013 15.8 21.2 1.8e+02 2.6 0.0 8.8 9 0 0 9 9 9 0 EGF-like domain COBRA PF04833.15 ORX60641.1 - 1.2 9.1 31.2 7.2 6.5 1.6 5.6 1 1 8 9 9 9 0 COBRA-like protein MTHFR PF02219.17 ORX60642.1 - 1.3e-116 389.0 0.0 1.7e-116 388.6 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase HMGL-like PF00682.19 ORX60643.1 - 6.2e-79 265.3 0.3 8.7e-79 264.8 0.3 1.2 1 0 0 1 1 1 1 HMGL-like Arrestin_C PF02752.22 ORX60644.1 - 0.00035 21.0 0.0 0.11 13.0 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain DHHC PF01529.20 ORX60645.1 - 0.00045 20.3 0.8 0.023 14.8 0.2 2.2 2 0 0 2 2 2 2 DHHC palmitoyltransferase OPT PF03169.15 ORX60646.1 - 4.4e-92 309.7 43.3 5e-92 309.5 43.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3093 PF11292.8 ORX60646.1 - 0.16 12.2 2.4 0.24 11.7 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) DUF4191 PF13829.6 ORX60646.1 - 3.4 7.0 5.5 1.1 8.6 1.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) RNA_pol_L_2 PF13656.6 ORX60647.1 - 7.9e-28 96.1 0.0 1.2e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ORX60647.1 - 1.2e-09 37.4 0.0 2.1e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Sacchrp_dh_NADP PF03435.18 ORX60648.1 - 8.1e-12 45.5 0.0 1.2e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Yip1 PF04893.17 ORX60648.1 - 0.096 12.4 2.4 0.19 11.4 2.4 1.4 1 0 0 1 1 1 0 Yip1 domain FAD_binding_3 PF01494.19 ORX60649.1 - 2.1e-22 79.9 0.0 7.5e-22 78.0 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ORX60649.1 - 3.1e-07 30.5 0.6 2.9e-06 27.4 0.5 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX60649.1 - 2.9e-06 26.7 0.5 0.00031 20.1 0.4 2.5 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX60649.1 - 5.4e-06 25.7 2.6 8.6e-06 25.1 2.6 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ORX60649.1 - 7.5e-05 21.6 1.2 0.00011 21.0 1.2 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 ORX60649.1 - 0.00044 19.7 3.2 0.0007 19.1 3.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ORX60649.1 - 0.00049 19.3 1.8 0.00087 18.5 1.8 1.4 1 0 0 1 1 1 1 Glucose inhibited division protein A Amino_oxidase PF01593.24 ORX60649.1 - 0.00077 18.9 3.4 0.037 13.3 0.3 2.8 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 ORX60649.1 - 0.00091 19.7 1.2 0.0032 18.0 0.4 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Rossmann-like PF10727.9 ORX60649.1 - 0.0019 18.1 0.1 0.0041 17.0 0.1 1.6 1 0 0 1 1 1 1 Rossmann-like domain Pyr_redox_3 PF13738.6 ORX60649.1 - 0.002 17.5 2.3 0.002 17.5 2.3 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX60649.1 - 0.0023 17.6 6.5 0.01 15.5 3.6 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ORX60649.1 - 0.0033 16.4 0.3 0.022 13.6 0.1 2.2 3 0 0 3 3 3 1 Tryptophan halogenase Lycopene_cycl PF05834.12 ORX60649.1 - 0.061 12.4 2.7 0.24 10.4 1.2 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ORX60649.1 - 0.15 11.4 1.9 0.26 10.6 1.9 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 ORX60649.1 - 0.19 10.9 1.3 0.41 9.8 1.3 1.5 1 0 0 1 1 1 0 Thi4 family UDPG_MGDP_dh_N PF03721.14 ORX60649.1 - 0.33 10.5 1.0 0.64 9.6 1.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 3HCDH_N PF02737.18 ORX60649.1 - 0.41 10.5 2.3 0.69 9.8 2.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amb_V_allergen PF03913.13 ORX60650.1 - 0.27 11.2 0.1 0.27 11.2 0.1 1.9 2 1 0 2 2 2 0 Amb V Allergen FAA_hydrolase PF01557.18 ORX60652.1 - 4e-59 199.9 0.0 5.5e-59 199.5 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Cpn60_TCP1 PF00118.24 ORX60653.1 - 7.7e-170 565.7 3.0 9.9e-170 565.4 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SAM_KSR1 PF13543.6 ORX60653.1 - 0.088 12.9 0.3 1.2 9.3 0.1 2.4 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 Pept_tRNA_hydro PF01195.19 ORX60654.1 - 4.3e-46 157.0 0.0 5.2e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase cobW PF02492.19 ORX60655.1 - 1.7e-51 174.3 0.4 2.2e-51 173.9 0.4 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ORX60655.1 - 2.3e-22 78.7 0.0 3.8e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain RsgA_GTPase PF03193.16 ORX60655.1 - 0.00017 21.5 0.4 0.62 10.0 0.1 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX60655.1 - 0.017 15.6 0.1 0.036 14.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 ORX60655.1 - 0.021 14.4 0.1 4.4 6.8 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF3479 PF11965.8 ORX60655.1 - 0.021 14.9 0.0 0.1 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3479) ATP_bind_1 PF03029.17 ORX60655.1 - 0.023 14.5 1.2 5.6 6.7 0.1 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ORX60655.1 - 0.036 14.6 1.6 0.63 10.6 1.6 2.4 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX60655.1 - 0.042 13.8 0.2 0.042 13.8 0.2 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MeaB PF03308.16 ORX60655.1 - 0.053 12.5 1.4 0.61 9.0 1.1 2.5 2 1 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_22 PF13401.6 ORX60655.1 - 0.066 13.5 0.5 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 ORX60655.1 - 0.12 11.9 1.9 0.77 9.3 0.2 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B SRPRB PF09439.10 ORX60655.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 ORX60655.1 - 0.15 11.9 0.3 0.53 10.1 0.3 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ORX60655.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ORX60655.1 - 0.16 11.0 0.5 0.29 10.1 0.2 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein FAD_binding_4 PF01565.23 ORX60656.1 - 4.1e-26 91.4 4.4 7e-26 90.6 4.4 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 ORX60656.1 - 0.0006 19.9 0.0 0.0014 18.7 0.0 1.6 1 0 0 1 1 1 1 Berberine and berberine like HSF_DNA-bind PF00447.17 ORX60657.1 - 1.2e-30 106.0 2.2 1.2e-30 106.0 2.2 1.7 2 0 0 2 2 2 1 HSF-type DNA-binding Pex24p PF06398.11 ORX60657.1 - 0.067 12.2 0.3 0.089 11.8 0.3 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Macoilin PF09726.9 ORX60657.1 - 0.13 10.8 2.8 0.18 10.3 2.8 1.1 1 0 0 1 1 1 0 Macoilin family RrnaAD PF00398.20 ORX60658.1 - 5.8e-63 212.4 0.1 7.7e-63 212.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ORX60658.1 - 3.3e-07 30.9 0.0 7.1e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX60658.1 - 2.4e-05 24.9 0.0 5.3e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX60658.1 - 8.6e-05 22.4 0.0 0.00014 21.7 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ORX60658.1 - 0.00034 20.2 0.0 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ORX60658.1 - 0.0012 18.7 0.0 0.0016 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX60658.1 - 0.0015 18.2 0.0 0.0029 17.3 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 CMAS PF02353.20 ORX60658.1 - 0.0018 17.7 0.0 0.0052 16.1 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ORX60658.1 - 0.0094 15.4 0.0 0.02 14.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ORX60658.1 - 0.01 16.6 0.0 0.02 15.6 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ORX60658.1 - 0.018 14.8 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 ORX60658.1 - 0.019 14.7 0.0 0.038 13.7 0.0 1.5 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_28 PF02636.17 ORX60658.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 ORX60658.1 - 0.03 14.2 0.1 0.084 12.7 0.0 1.7 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase NodS PF05401.11 ORX60658.1 - 0.097 12.3 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 ORX60658.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ACOX PF01756.19 ORX60659.1 - 1e-39 136.0 0.1 2.3e-39 134.8 0.1 1.6 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ORX60659.1 - 3.2e-11 43.3 0.0 6.8e-11 42.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ORX60659.1 - 2.4e-10 41.0 0.0 3.4e-08 34.1 0.0 2.8 2 1 1 3 3 3 2 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 ORX60659.1 - 0.00036 20.8 0.1 0.0016 18.6 0.1 2.3 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Rcd1 PF04078.13 ORX60660.1 - 6.3e-125 415.7 6.3 7.1e-125 415.5 6.3 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like MBOAT PF03062.19 ORX60661.1 - 2.9e-21 76.2 9.7 3.4e-21 76.0 9.7 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 ORX60661.1 - 0.026 14.8 1.8 0.026 14.8 1.8 2.0 2 0 0 2 2 2 0 Membrane bound O-acyl transferase family DUF1674 PF07896.12 ORX60662.1 - 8.3e-20 71.0 1.8 1e-19 70.7 1.8 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) Spo7 PF03907.13 ORX60663.1 - 1.1e-24 87.2 12.0 2e-23 83.1 3.3 2.1 1 1 1 2 2 2 2 Spo7-like protein Tmemb_18A PF09771.9 ORX60663.1 - 0.00037 20.9 0.2 0.00047 20.5 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 188 DUF485 PF04341.12 ORX60663.1 - 0.0094 15.9 1.6 0.015 15.2 1.6 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF485 DUF2721 PF11026.8 ORX60663.1 - 0.03 14.2 0.5 0.043 13.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) DUF2614 PF11023.8 ORX60663.1 - 0.055 13.6 0.2 0.077 13.1 0.2 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain PX PF00787.24 ORX60664.1 - 2.3e-20 72.6 0.3 9.2e-20 70.7 0.0 2.1 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 ORX60664.1 - 1.5e-16 60.7 15.7 7.1e-11 42.1 4.9 2.1 1 1 1 2 2 2 2 Vps5 C terminal like FlaC_arch PF05377.11 ORX60664.1 - 0.00083 19.7 1.2 0.0093 16.3 0.0 2.6 2 0 0 2 2 2 1 Flagella accessory protein C (FlaC) Sec34 PF04136.15 ORX60664.1 - 0.0054 16.6 1.0 0.0054 16.6 1.0 2.4 2 1 0 2 2 2 1 Sec34-like family Topoisom_I_N PF02919.15 ORX60664.1 - 0.097 12.2 0.5 0.23 11.0 0.5 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment LMBR1 PF04791.16 ORX60664.1 - 4.1 6.2 9.7 4.4 6.1 0.1 2.0 1 1 1 2 2 2 0 LMBR1-like membrane protein JAB PF01398.21 ORX60665.1 - 2.1e-15 56.7 0.0 4.2e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SWIRM PF04433.17 ORX60665.1 - 1e-10 41.8 0.0 2.4e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 SWIRM domain Prok-JAB PF14464.6 ORX60665.1 - 3.7e-08 33.2 0.2 4.7e-07 29.6 0.0 2.3 2 0 0 2 2 2 1 Prokaryotic homologs of the JAB domain TPT PF03151.16 ORX60666.1 - 9.6e-05 21.9 10.3 0.013 14.9 2.9 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 ORX60666.1 - 0.0008 19.6 14.4 0.0008 19.6 14.4 2.4 2 1 0 2 2 2 2 EamA-like transporter family DUF3759 PF12585.8 ORX60667.1 - 1.7e-36 124.1 8.6 2e-36 123.9 8.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) SRP40_C PF05022.12 ORX60667.1 - 0.085 13.7 1.4 0.21 12.5 0.4 1.9 1 1 1 2 2 2 0 SRP40, C-terminal domain CTP_transf_1 PF01148.20 ORX60668.1 - 5.9e-48 163.9 16.1 8.1e-48 163.5 16.1 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family tRNA-synt_1c PF00749.21 ORX60669.1 - 9.7e-113 376.2 0.1 1.3e-112 375.8 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 ORX60669.1 - 2.3e-51 174.0 0.1 4.2e-51 173.2 0.1 1.5 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 ORX60669.1 - 3.4e-33 115.0 0.1 1e-32 113.4 0.1 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 ORX60669.1 - 2.6e-12 47.5 2.0 6.8e-12 46.2 2.0 1.7 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 rpo30_N PF12410.8 ORX60669.1 - 0.072 13.0 0.1 0.43 10.5 0.0 2.2 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit zf-Mss51 PF13824.6 ORX60670.1 - 0.0081 16.2 1.0 0.017 15.2 1.0 1.5 1 1 1 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 TFIIS_C PF01096.18 ORX60670.1 - 0.12 12.3 1.2 9.3 6.2 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) PALP PF00291.25 ORX60672.1 - 5.4e-76 255.8 0.3 7.2e-76 255.4 0.3 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 ORX60672.1 - 2.5e-44 149.0 0.0 5.3e-24 83.8 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase Fungal_KA1 PF16797.5 ORX60672.1 - 0.16 11.7 0.0 0.38 10.5 0.0 1.6 1 0 0 1 1 1 0 Fungal kinase associated-1 domain DnaJ PF00226.31 ORX60673.1 - 4.3e-17 62.0 0.1 8.4e-17 61.1 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain Syntaxin PF00804.25 ORX60674.1 - 9.4e-20 71.1 20.3 1.9e-19 70.2 20.3 1.5 1 1 0 1 1 1 1 Syntaxin SNARE PF05739.19 ORX60674.1 - 1.7e-09 37.5 0.8 1.7e-09 37.5 0.8 3.5 3 0 0 3 3 3 1 SNARE domain ODV-E18 PF10717.9 ORX60674.1 - 0.0058 16.5 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 Occlusion-derived virus envelope protein ODV-E18 Syntaxin_2 PF14523.6 ORX60674.1 - 0.0064 16.8 17.3 0.19 12.1 2.4 3.4 2 2 1 3 3 3 2 Syntaxin-like protein DUF2839 PF10999.8 ORX60674.1 - 0.05 14.0 0.3 0.19 12.1 0.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) DUF3671 PF12420.8 ORX60674.1 - 0.059 13.4 0.6 0.13 12.3 0.1 1.8 2 0 0 2 2 1 0 Protein of unknown function Nas2_N PF18265.1 ORX60674.1 - 0.1 12.5 3.6 0.76 9.7 0.3 3.1 2 1 0 2 2 2 0 Nas2 N_terminal domain DUF2207 PF09972.9 ORX60674.1 - 0.13 11.0 0.4 4.2 6.0 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) FlaC_arch PF05377.11 ORX60674.1 - 0.14 12.5 5.7 4.8 7.6 0.1 4.0 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) 7tm_6 PF02949.20 ORX60674.1 - 0.26 10.3 2.4 7.3 5.6 2.6 2.4 2 1 0 2 2 2 0 7tm Odorant receptor 7tm_7 PF08395.12 ORX60674.1 - 0.37 10.0 2.5 4.3 6.4 0.3 2.3 2 0 0 2 2 2 0 7tm Chemosensory receptor TolA_bind_tri PF16331.5 ORX60674.1 - 0.5 10.5 20.5 0.26 11.4 5.7 3.6 3 2 0 3 3 2 0 TolA binding protein trimerisation DASH_Dam1 PF08653.10 ORX60674.1 - 2.6 7.9 6.6 9.5 6.1 0.4 2.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 DUF5344 PF17279.2 ORX60674.1 - 4.5 7.9 10.3 2.1 9.0 1.0 3.8 4 2 0 4 4 3 0 Family of unknown function (DUF5344) Colicin-DNase PF12639.7 ORX60674.1 - 7.3 7.5 7.0 7.2 7.5 0.4 2.9 1 1 1 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin DUF922 PF06037.11 ORX60674.1 - 7.6 6.3 12.1 0.24 11.2 4.4 2.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF922) DUF4094 PF13334.6 ORX60674.1 - 8.4 6.9 9.9 3.5 8.1 1.8 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4094) HLH PF00010.26 ORX60675.1 - 1e-12 47.8 2.5 2e-12 46.8 2.5 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain HSP90 PF00183.18 ORX60675.1 - 0.0089 15.0 0.7 0.013 14.4 0.7 1.2 1 0 0 1 1 1 1 Hsp90 protein NRBF2 PF08961.10 ORX60675.1 - 0.016 14.8 1.3 0.016 14.8 1.3 1.8 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator YabA PF06156.13 ORX60675.1 - 0.53 11.0 6.5 0.25 12.0 3.1 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Aa_trans PF01490.18 ORX60676.1 - 3.8e-55 187.3 24.2 5e-55 186.9 24.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein zf-RING_13 PF17977.1 ORX60676.1 - 0.025 14.7 1.8 0.062 13.4 1.8 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Sec23_trunk PF04811.15 ORX60677.1 - 1.8e-77 260.2 0.0 2.5e-77 259.7 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ORX60677.1 - 7.9e-31 106.7 1.2 1.5e-30 105.8 1.2 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 ORX60677.1 - 5.4e-24 84.0 0.1 1.1e-23 83.0 0.1 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ORX60677.1 - 3.2e-15 55.9 6.2 6.4e-15 54.9 6.2 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 ORX60677.1 - 3.3e-14 52.5 0.0 9e-14 51.1 0.0 1.8 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 ORX60677.1 - 0.074 12.5 0.1 0.17 11.3 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PseudoU_synth_1 PF01416.20 ORX60678.1 - 1.5e-28 99.4 0.0 6.2e-28 97.4 0.0 2.0 2 0 0 2 2 2 1 tRNA pseudouridine synthase SNF5 PF04855.12 ORX60681.1 - 2.4e-60 204.3 0.7 1.5e-33 116.6 0.0 2.4 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 OrfB_Zn_ribbon PF07282.11 ORX60682.1 - 2.6e-08 33.7 2.6 6e-08 32.5 2.6 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zinc_ribbon_15 PF17032.5 ORX60682.1 - 0.5 11.1 5.2 3.3 8.5 3.2 2.3 2 0 0 2 2 2 0 zinc-ribbon family zf-FPG_IleRS PF06827.14 ORX60682.1 - 1.6 8.6 5.7 0.29 11.0 1.0 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS EGL-1 PF11430.8 ORX60683.1 - 3.8 7.5 5.8 8.9 6.3 5.8 1.6 1 0 0 1 1 1 0 Programmed cell death activator EGL-1 HEAT_2 PF13646.6 ORX60685.1 - 2.1e-09 37.6 1.2 0.03 14.7 0.1 4.5 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ORX60685.1 - 4.5e-09 35.8 5.2 0.08 13.2 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.7 ORX60685.1 - 2.3e-05 24.5 9.6 0.0023 18.0 0.3 3.9 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ORX60685.1 - 0.0068 16.6 3.7 1 9.6 0.3 3.9 4 2 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 ORX60685.1 - 0.013 15.7 0.2 0.12 12.8 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion CLASP_N PF12348.8 ORX60685.1 - 0.022 14.3 1.7 0.13 11.8 0.1 2.9 3 0 0 3 3 3 0 CLASP N terminal DUF4042 PF13251.6 ORX60685.1 - 0.2 11.4 2.3 0.51 10.0 0.3 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4042) Pyr_redox_2 PF07992.14 ORX60686.1 - 1.4e-27 96.7 0.0 1.9e-27 96.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX60686.1 - 2.2e-11 44.1 0.1 7.3e-07 29.7 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX60686.1 - 1.4e-06 28.2 0.1 0.11 12.1 0.0 3.0 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX60686.1 - 0.00087 19.5 0.0 1.4 9.2 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain TrkA_N PF02254.18 ORX60686.1 - 0.0029 17.9 0.1 0.13 12.5 0.0 2.4 2 0 0 2 2 2 1 TrkA-N domain Lycopene_cycl PF05834.12 ORX60686.1 - 0.0049 16.0 0.0 0.86 8.6 0.0 2.3 2 0 0 2 2 2 2 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ORX60686.1 - 0.0051 16.1 0.0 0.014 14.7 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ORX60686.1 - 0.01 15.1 0.1 3.6 6.7 0.0 2.2 2 0 0 2 2 2 0 FAD binding domain NAD_binding_9 PF13454.6 ORX60686.1 - 0.013 15.4 0.1 14 5.7 0.0 3.6 2 1 1 3 3 3 0 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ORX60686.1 - 0.021 13.7 0.0 0.36 9.6 0.0 2.2 2 0 0 2 2 2 0 Tryptophan halogenase K_oxygenase PF13434.6 ORX60686.1 - 0.026 13.6 0.0 0.38 9.8 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 ORX60686.1 - 0.032 13.3 0.1 9.9 5.1 0.0 3.0 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_7 PF13241.6 ORX60686.1 - 0.038 14.4 0.0 11 6.6 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 ORX60686.1 - 0.052 13.1 0.3 0.17 11.4 0.1 1.9 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 ORX60686.1 - 0.099 11.9 0.1 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Tim44 PF04280.15 ORX60687.1 - 3.5e-37 127.8 0.1 3.5e-37 127.8 0.1 2.0 2 1 0 1 1 1 1 Tim44-like domain CENP-O PF09496.10 ORX60687.1 - 2.4 8.1 7.1 1.7 8.5 5.1 1.7 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component Arc_PepC PF06819.11 ORX60687.1 - 2.8 8.1 7.8 4.8 7.3 0.1 3.5 2 2 1 3 3 3 0 Archaeal Peptidase A24 C-terminal Domain NDT80_PhoG PF05224.12 ORX60688.1 - 3.6e-34 118.6 0.0 9.2e-34 117.3 0.0 1.7 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family RRM_1 PF00076.22 ORX60689.1 - 0.00021 21.0 0.0 0.00069 19.4 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PNP_UDP_1 PF01048.20 ORX60690.1 - 3e-38 131.4 0.0 3.5e-38 131.2 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily PUD1_2 PF18457.1 ORX60690.1 - 0.077 13.0 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Up-Regulated in long-lived daf-2 Pkinase PF00069.25 ORX60691.1 - 1.2e-69 234.6 0.0 2.9e-69 233.4 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60691.1 - 7.4e-44 150.0 0.0 2.8e-43 148.1 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX60691.1 - 5.8e-06 26.4 1.7 0.011 15.6 0.1 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 ORX60691.1 - 1.1e-05 25.0 0.2 2.6e-05 23.7 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX60691.1 - 0.00053 19.4 0.0 0.00084 18.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX60691.1 - 0.0013 17.7 0.1 0.003 16.6 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ORX60691.1 - 0.03 13.9 0.1 0.03 13.9 0.1 1.9 2 0 0 2 2 2 0 RIO1 family EcKinase PF02958.20 ORX60691.1 - 0.093 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 Ecdysteroid kinase YrbL-PhoP_reg PF10707.9 ORX60691.1 - 0.22 11.1 0.0 0.22 11.1 0.0 2.2 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ORX60691.1 - 0.33 9.7 0.0 0.33 9.7 0.0 2.3 3 0 0 3 3 3 0 Fungal protein kinase Abhydrolase_1 PF00561.20 ORX60692.1 - 3.2e-14 53.2 0.0 4e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX60692.1 - 2.7e-10 41.2 0.0 3.2e-10 41.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX60692.1 - 2.7e-09 36.6 0.0 4.2e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ORX60692.1 - 2.3e-06 27.9 0.0 3.2e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 ORX60692.1 - 0.00053 19.8 0.0 0.0044 16.8 0.0 2.3 2 1 1 3 3 3 1 PGAP1-like protein Esterase PF00756.20 ORX60692.1 - 0.001 18.8 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Lipase_3 PF01764.25 ORX60692.1 - 0.0084 16.0 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase2 PF12740.7 ORX60692.1 - 0.1 11.5 0.0 0.15 11.0 0.0 1.3 1 1 0 1 1 1 0 Chlorophyllase enzyme Chlorophyllase PF07224.11 ORX60692.1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase NinB PF05772.12 ORX60693.1 - 0.12 12.2 0.2 0.19 11.6 0.2 1.2 1 0 0 1 1 1 0 NinB protein RPEL PF02755.15 ORX60694.1 - 2.4e-19 68.3 6.4 1.1e-05 25.0 0.1 4.2 4 1 1 5 5 5 3 RPEL repeat DnaI_N PF07319.11 ORX60694.1 - 0.013 16.1 0.0 0.029 15.0 0.0 1.6 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus DUF5635 PF18685.1 ORX60694.1 - 0.021 14.7 0.0 0.96 9.4 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5635) zf-RING_2 PF13639.6 ORX60695.1 - 2.3e-10 40.6 11.1 3.9e-10 39.9 11.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX60695.1 - 2.3e-08 34.2 12.0 4.1e-08 33.4 12.0 1.5 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ORX60695.1 - 2.9e-06 27.0 9.3 5.7e-06 26.1 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX60695.1 - 9.4e-06 25.4 9.5 9.4e-06 25.4 9.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ORX60695.1 - 4e-05 23.6 6.7 6.4e-05 22.9 6.7 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ORX60695.1 - 9.6e-05 22.1 8.6 0.00022 20.9 8.6 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ORX60695.1 - 0.00036 20.5 6.9 0.00091 19.2 6.9 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ORX60695.1 - 0.0019 18.1 9.3 0.0022 17.9 8.4 1.6 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ORX60695.1 - 0.012 15.4 11.4 0.021 14.7 11.4 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ORX60695.1 - 0.81 9.4 15.7 0.7 9.6 13.7 1.8 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zinc_ribbon_16 PF17034.5 ORX60695.1 - 2.3 8.5 10.8 2.3 8.4 9.9 1.5 1 1 0 1 1 1 0 Zinc-ribbon like family zf-C3H2C3 PF17122.5 ORX60695.1 - 2.6 8.1 13.1 4.4 7.4 11.3 2.3 2 1 0 2 2 2 0 Zinc-finger FANCL_C PF11793.8 ORX60695.1 - 5.1 7.3 11.5 65 3.8 11.4 2.4 1 1 1 2 2 2 0 FANCL C-terminal domain NnrU PF07298.11 ORX60696.1 - 0.0042 16.6 1.5 0.19 11.2 0.0 2.0 1 1 1 2 2 2 2 NnrU protein RNB PF00773.19 ORX60697.1 - 2.2e-73 247.4 0.1 3.2e-73 246.9 0.1 1.2 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ORX60697.1 - 5.5e-21 74.4 0.0 1.1e-20 73.4 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 ORX60697.1 - 2.3e-15 56.7 0.0 5.6e-15 55.4 0.0 1.7 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_CSD1 PF17216.3 ORX60697.1 - 0.013 15.2 2.9 0.32 10.7 0.0 2.4 2 0 0 2 2 2 0 Rrp44-like cold shock domain UPF0180 PF03698.13 ORX60697.1 - 0.099 12.8 0.1 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) OB_RNB PF08206.11 ORX60697.1 - 0.11 12.1 0.1 0.52 10.0 0.0 2.2 2 0 0 2 2 2 0 Ribonuclease B OB domain A_deamin PF02137.18 ORX60698.1 - 3e-68 230.7 0.5 5.8e-68 229.8 0.5 1.4 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain SNAD4 PF18750.1 ORX60698.1 - 0.09 12.9 0.0 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 Cyclin PF08613.11 ORX60699.1 - 3.1e-13 50.4 0.1 4.1e-13 50.0 0.1 1.1 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX60699.1 - 4.9e-07 29.5 0.0 7.1e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Pmp3 PF01679.17 ORX60700.1 - 7.3e-22 77.3 6.1 8.2e-22 77.2 6.1 1.1 1 0 0 1 1 1 1 Proteolipid membrane potential modulator bZIP_1 PF00170.21 ORX60701.1 - 1e-09 38.3 10.0 2e-09 37.4 10.0 1.5 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ORX60701.1 - 6.5e-06 26.1 10.8 6.5e-06 26.1 10.8 1.7 2 0 0 2 2 2 1 Basic region leucine zipper bZIP_Maf PF03131.17 ORX60701.1 - 0.014 15.9 7.2 0.014 15.9 7.2 1.6 1 1 1 2 2 2 0 bZIP Maf transcription factor NRBF2 PF08961.10 ORX60701.1 - 3.1 7.4 11.4 69 3.0 11.4 2.2 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Abhydrolase_1 PF00561.20 ORX60702.1 - 5.5e-27 95.0 0.3 1.3e-25 90.5 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX60702.1 - 9.6e-23 81.9 0.0 1.2e-22 81.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX60702.1 - 2.5e-13 49.9 0.1 5.6e-12 45.4 0.1 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ORX60702.1 - 6.5e-07 29.7 0.1 1.1e-06 29.0 0.1 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 ORX60702.1 - 5.3e-06 26.3 0.0 0.051 13.3 0.0 2.2 1 1 1 2 2 2 2 PGAP1-like protein Esterase PF00756.20 ORX60702.1 - 4.6e-05 23.2 0.0 6e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 ORX60702.1 - 0.0002 20.1 0.0 0.0039 15.9 0.0 2.0 1 1 0 1 1 1 1 Ndr family PAF-AH_p_II PF03403.13 ORX60702.1 - 0.005 15.4 0.0 3 6.3 0.0 3.0 2 1 0 3 3 3 1 Platelet-activating factor acetylhydrolase, isoform II DUF676 PF05057.14 ORX60702.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ORX60702.1 - 0.073 12.9 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Palmitoyl protein thioesterase DUF2974 PF11187.8 ORX60702.1 - 0.076 12.6 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Acetyltransf_CG PF14542.6 ORX60705.1 - 3.3e-15 56.0 0.0 4.7e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Caleosin PF05042.13 ORX60706.1 - 0.055 13.4 0.1 0.34 10.8 0.1 2.0 1 1 0 1 1 1 0 Caleosin related protein DUF4112 PF13430.6 ORX60707.1 - 9.6e-33 112.6 0.9 1.3e-32 112.2 0.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Cas_Csm6 PF09659.10 ORX60707.1 - 0.035 12.9 0.0 0.05 12.4 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) TFIID_30kDa PF03540.13 ORX60708.1 - 4.6e-27 93.7 0.3 6.8e-27 93.2 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 ORX60708.1 - 3.5e-05 23.7 0.1 0.0013 18.7 0.0 2.4 2 1 0 2 2 2 1 Bromodomain associated FtsK_alpha PF17854.1 ORX60708.1 - 0.0075 16.4 0.0 0.55 10.4 0.0 2.1 2 0 0 2 2 2 1 FtsK alpha domain TAF4 PF05236.14 ORX60708.1 - 0.024 14.4 0.1 0.029 14.1 0.1 1.3 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CBFD_NFYB_HMF PF00808.23 ORX60708.1 - 0.062 13.6 0.2 1.9 8.8 0.2 2.3 1 1 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone E1-E2_ATPase PF00122.20 ORX60709.1 - 2.1e-51 174.0 0.1 4.6e-50 169.7 0.0 2.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX60709.1 - 1.9e-15 57.7 0.8 3.3e-14 53.7 0.8 2.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX60709.1 - 1.1e-11 44.2 0.0 2.5e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX60709.1 - 1.3e-05 25.1 0.2 3.4e-05 23.7 0.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX60709.1 - 0.015 15.4 0.0 0.03 14.4 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) SWIRM PF04433.17 ORX60710.1 - 9.5e-24 83.6 0.2 1e-22 80.3 0.1 2.4 2 0 0 2 2 2 1 SWIRM domain JAB PF01398.21 ORX60710.1 - 9.1e-10 38.5 0.0 2.4e-09 37.2 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ORX60710.1 - 2.9e-07 30.3 0.1 6.6e-07 29.1 0.1 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Myb_DNA-binding PF00249.31 ORX60710.1 - 2.7e-06 27.5 0.1 7e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX60710.1 - 0.013 15.7 1.8 0.02 15.2 0.0 2.2 3 0 0 3 3 3 0 Myb-like DNA-binding domain RPEL PF02755.15 ORX60711.1 - 8.3e-16 57.1 1.9 1.8e-08 33.8 0.7 2.5 2 0 0 2 2 2 2 RPEL repeat Epsilon_antitox PF08998.11 ORX60711.1 - 0.098 12.9 0.1 0.12 12.6 0.1 1.3 1 1 0 1 1 1 0 Bacterial epsilon antitoxin Aldedh PF00171.22 ORX60712.1 - 3.4e-131 438.0 0.1 4.4e-131 437.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Gin PF10764.9 ORX60713.1 - 0.11 12.4 0.2 0.16 12.0 0.2 1.2 1 0 0 1 1 1 0 Inhibitor of sigma-G Gin Amino_oxidase PF01593.24 ORX60714.1 - 5e-29 101.9 0.0 8.6e-29 101.1 0.0 1.4 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ORX60714.1 - 2.2e-14 53.4 0.1 5.3e-14 52.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX60714.1 - 7.9e-12 45.4 0.0 2.6e-11 43.7 0.0 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX60714.1 - 1.8e-10 40.5 0.0 3.4e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ORX60714.1 - 5.8e-08 32.2 2.2 6e-06 25.6 2.1 2.2 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ORX60714.1 - 7e-07 28.9 0.0 6.9e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX60714.1 - 4.3e-06 25.7 0.5 0.00018 20.4 0.9 2.1 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ORX60714.1 - 4.2e-05 22.8 2.7 0.0027 16.9 1.6 2.3 2 0 0 2 2 2 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ORX60714.1 - 8.2e-05 22.6 0.3 0.04 13.9 0.3 2.5 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 ORX60714.1 - 0.00018 22.0 3.7 0.044 14.3 1.6 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX60714.1 - 0.00045 19.5 0.2 0.00083 18.7 0.2 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_3 PF01494.19 ORX60714.1 - 0.00061 19.1 0.4 0.00091 18.6 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain Lycopene_cycl PF05834.12 ORX60714.1 - 0.0045 16.1 1.9 0.018 14.1 0.5 2.3 2 0 0 2 2 2 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 ORX60714.1 - 0.0048 16.2 2.5 0.0069 15.7 1.5 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ORX60714.1 - 0.015 15.7 0.0 0.028 14.9 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 ORX60714.1 - 0.025 14.1 0.3 0.052 13.1 0.3 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 ORX60714.1 - 0.028 14.0 0.1 0.098 12.3 0.2 1.9 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA MutS_I PF01624.20 ORX60714.1 - 0.029 14.6 0.1 0.14 12.4 0.1 2.0 2 0 0 2 2 2 0 MutS domain I Trp_halogenase PF04820.14 ORX60714.1 - 0.032 13.1 5.9 0.088 11.6 0.5 2.8 4 0 0 4 4 4 0 Tryptophan halogenase adh_short PF00106.25 ORX60714.1 - 0.043 13.3 1.1 0.069 12.6 1.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase DUF410 PF04190.13 ORX60714.1 - 0.066 13.0 0.2 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF410) 3HCDH_N PF02737.18 ORX60714.1 - 0.07 13.0 1.1 0.13 12.1 1.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IlvN PF07991.12 ORX60714.1 - 0.07 12.7 0.2 0.15 11.6 0.2 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ORX60714.1 - 0.16 12.2 0.2 0.4 10.9 0.2 1.7 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 ORX60714.1 - 0.21 10.9 0.7 1.6 8.1 0.4 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX60714.1 - 0.22 11.6 0.6 0.41 10.7 0.6 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase SQS_PSY PF00494.19 ORX60715.1 - 3.3e-53 180.9 0.1 4.7e-53 180.4 0.1 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Polysacc_deac_1 PF01522.21 ORX60717.1 - 5.7e-32 110.2 0.0 8.5e-32 109.7 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Vac_ImportDeg PF09783.9 ORX60718.1 - 1.5e-55 187.4 3.1 1.8e-55 187.1 3.1 1.1 1 0 0 1 1 1 1 Vacuolar import and degradation protein AA_permease PF00324.21 ORX60719.1 - 1.7e-27 96.2 10.7 1.9e-27 96.0 10.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX60719.1 - 8.4e-08 31.5 7.6 9.2e-08 31.3 7.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ORX60720.1 - 5.1e-81 272.7 22.4 6.3e-81 272.4 22.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX60720.1 - 1.3e-33 116.5 24.8 1.6e-33 116.2 24.8 1.1 1 0 0 1 1 1 1 Amino acid permease Peroxidase_2 PF01328.17 ORX60721.1 - 6e-37 128.0 0.0 8e-37 127.6 0.0 1.1 1 0 0 1 1 1 1 Peroxidase, family 2 Pkinase PF00069.25 ORX60722.1 - 1.5e-35 122.9 0.0 1.7e-35 122.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX60722.1 - 4.4e-30 104.8 0.0 5.4e-30 104.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX60722.1 - 0.0079 15.5 0.0 0.016 14.5 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX60722.1 - 0.098 12.0 0.2 0.13 11.6 0.2 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX60722.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Fungal_trans PF04082.18 ORX60723.1 - 3.6e-36 124.6 0.0 6.3e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX60723.1 - 4.5e-08 33.1 7.6 7.8e-08 32.3 7.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Atg14 PF10186.9 ORX60724.1 - 2.1e-11 43.5 12.1 1.3e-09 37.7 12.1 2.2 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 ORX60724.1 - 1.3e-07 30.8 2.2 2.4e-07 30.0 0.5 2.0 2 0 0 2 2 2 1 Vacuolar protein sorting 38 Filament PF00038.21 ORX60724.1 - 0.0054 16.3 8.5 0.0083 15.8 8.5 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF724 PF05266.14 ORX60724.1 - 0.019 14.8 7.6 0.03 14.1 7.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 ORX60724.1 - 0.045 12.6 8.7 0.067 12.1 8.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein OmpH PF03938.14 ORX60724.1 - 0.49 10.7 9.0 0.83 10.0 9.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 ORX60724.1 - 0.63 9.6 9.6 0.94 9.0 9.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ORX60724.1 - 1.8 7.8 4.7 2.5 7.4 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ORX60724.1 - 4.3 6.0 5.0 6.9 5.4 5.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Erythro_esteras PF05139.14 ORX60724.1 - 4.9 6.9 7.1 7.8 6.2 7.1 1.2 1 0 0 1 1 1 0 Erythromycin esterase Aldedh PF00171.22 ORX60725.1 - 2e-178 593.7 1.0 2.3e-178 593.5 1.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 ORX60725.1 - 0.074 12.5 0.2 2.1 7.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Peptidase_M1 PF01433.20 ORX60726.1 - 8.9e-81 270.6 3.8 1.4e-80 270.0 3.8 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ORX60726.1 - 1.5e-74 251.4 6.2 8.4e-74 248.9 3.6 2.2 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 ORX60726.1 - 4.4e-55 186.8 0.0 7.7e-55 186.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DUF2808 PF10989.8 ORX60726.1 - 0.09 12.8 0.0 0.63 10.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2808) zf-H2C2_2 PF13465.6 ORX60727.1 - 1.9e-25 88.1 20.6 1e-07 32.1 0.3 5.2 5 0 0 5 5 5 4 Zinc-finger double domain zf-C2H2 PF00096.26 ORX60727.1 - 7.4e-21 73.4 31.3 5.5e-06 26.5 2.0 4.3 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX60727.1 - 2.5e-11 43.4 28.5 0.0033 18.2 1.4 4.3 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX60727.1 - 2.4e-06 27.7 5.3 0.32 11.3 0.4 4.3 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX60727.1 - 3.4e-06 27.6 10.5 0.12 13.1 0.4 4.0 2 1 2 4 4 4 3 FOXP coiled-coil domain zf-met PF12874.7 ORX60727.1 - 0.003 17.9 7.8 5 7.7 0.1 4.4 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-TRAF PF02176.18 ORX60727.1 - 0.0051 17.5 1.5 0.0051 17.5 1.5 3.1 1 1 2 3 3 3 1 TRAF-type zinc finger Ogr_Delta PF04606.12 ORX60727.1 - 0.13 12.3 9.9 0.27 11.2 0.8 3.5 1 1 3 4 4 4 0 Ogr/Delta-like zinc finger zf-C2H2_11 PF16622.5 ORX60727.1 - 0.56 10.0 17.6 1.3 8.8 1.9 3.5 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-C2H2_aberr PF17017.5 ORX60727.1 - 1.3 9.1 8.2 26 4.9 0.1 3.7 1 1 3 4 4 4 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 ORX60727.1 - 3 8.0 16.9 3.9 7.6 0.8 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger tRNA-synt_1g PF09334.11 ORX60728.1 - 4.8e-154 512.8 0.4 6.5e-154 512.4 0.4 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ORX60728.1 - 1.6e-11 43.2 0.2 5.2e-07 28.3 0.1 3.2 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX60728.1 - 0.0021 18.0 0.2 0.0076 16.2 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ORX60728.1 - 0.0066 15.8 0.0 0.039 13.3 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain AIF_C PF14721.6 ORX60728.1 - 0.045 14.1 0.2 0.092 13.1 0.2 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term zf-C3HC4_3 PF13920.6 ORX60728.1 - 0.068 13.1 0.1 0.18 11.7 0.1 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Synaptonemal_3 PF15191.6 ORX60728.1 - 0.15 11.9 0.1 0.57 10.0 0.1 2.0 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 zinc-ribbons_6 PF07191.12 ORX60728.1 - 0.99 9.4 7.0 0.16 12.0 2.9 1.8 2 0 0 2 2 2 0 zinc-ribbons DZR PF12773.7 ORX60728.1 - 1.3 9.1 8.2 4.6 7.3 8.2 2.0 1 1 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 ORX60728.1 - 4.2 7.4 5.9 2 8.4 2.3 2.4 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA L51_S25_CI-B8 PF05047.16 ORX60729.1 - 4.6e-10 39.2 0.0 6.3e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Lipase_GDSL_3 PF14606.6 ORX60729.1 - 0.03 14.4 0.0 0.037 14.2 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family NUMOD4 PF07463.11 ORX60730.1 - 0.00058 20.0 0.2 0.022 15.0 0.0 3.0 3 0 0 3 3 3 1 NUMOD4 motif PQQ PF01011.21 ORX60730.1 - 0.17 11.9 0.9 11 6.2 0.2 3.2 2 1 0 2 2 2 0 PQQ enzyme repeat HNH_3 PF13392.6 ORX60731.1 - 0.011 15.5 0.1 0.027 14.2 0.1 1.7 1 0 0 1 1 1 0 HNH endonuclease HNH_3 PF13392.6 ORX60732.1 - 1.3e-24 85.7 3.7 3.4e-14 52.3 0.1 2.7 3 0 0 3 3 3 2 HNH endonuclease NUMOD4 PF07463.11 ORX60732.1 - 0.0042 17.3 0.0 0.027 14.7 0.0 2.2 2 0 0 2 2 2 1 NUMOD4 motif DUF4218 PF13960.6 ORX60735.1 - 2.5e-05 23.9 0.0 3.6e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4218) CAT PF00302.18 ORX61276.1 - 0.083 12.8 0.0 0.09 12.7 0.0 1.0 1 0 0 1 1 1 0 Chloramphenicol acetyltransferase Eclosion PF04736.12 ORX61276.1 - 0.13 12.0 2.6 6.4 6.6 0.0 2.2 2 0 0 2 2 2 0 Eclosion hormone Fe-S_biosyn PF01521.20 ORX61277.1 - 4e-21 75.3 0.0 5.5e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DRMBL PF07522.14 ORX61278.1 - 9e-32 109.5 0.0 2e-31 108.5 0.0 1.6 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 ORX61278.1 - 0.0049 16.4 0.1 0.01 15.4 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RNF220 PF15926.5 ORX61278.1 - 0.018 14.7 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Lactamase_B PF00753.27 ORX61278.1 - 0.063 13.3 3.2 0.13 12.2 3.2 1.4 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily RMMBL PF07521.12 ORX61278.1 - 0.1 12.6 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain PPR_2 PF13041.6 ORX61279.1 - 1.1e-36 124.8 0.0 6.4e-07 29.5 0.0 10.7 8 2 3 11 11 11 6 PPR repeat family PPR PF01535.20 ORX61279.1 - 4e-25 86.3 0.0 0.00013 22.0 0.0 9.1 9 0 0 9 9 9 5 PPR repeat PPR_3 PF13812.6 ORX61279.1 - 2.4e-24 85.2 0.0 0.0015 18.6 0.0 9.0 7 3 2 9 9 9 6 Pentatricopeptide repeat domain PPR_1 PF12854.7 ORX61279.1 - 1.8e-23 81.9 0.0 0.00021 20.9 0.0 8.2 9 0 0 9 9 9 5 PPR repeat PPR_long PF17177.4 ORX61279.1 - 2.1e-11 43.6 0.0 1.7e-07 30.8 0.0 4.9 4 2 2 6 6 6 1 Pentacotripeptide-repeat region of PRORP TPR_14 PF13428.6 ORX61279.1 - 0.00022 21.8 0.5 6.6 7.8 0.0 6.0 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX61279.1 - 0.0015 19.0 0.2 1.1 9.9 0.0 5.0 5 1 3 8 8 7 1 Tetratricopeptide repeat FERM_M PF00373.18 ORX61279.1 - 0.013 15.9 1.0 7.2 7.0 0.1 2.6 2 0 0 2 2 2 0 FERM central domain DUF1735 PF08522.10 ORX61279.1 - 0.031 14.9 0.0 0.059 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1735) ECSIT PF06239.11 ORX61279.1 - 0.1 11.7 2.8 20 4.2 0.0 4.0 4 1 1 5 5 5 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_2 PF07719.17 ORX61279.1 - 0.12 12.6 0.5 72 3.9 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Molybdopterin_N PF18364.1 ORX61280.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin oxidoreductase N-terminal domain Chitin_synth_2 PF03142.15 ORX61281.1 - 9.3e-245 813.2 1.8 1.3e-244 812.7 1.8 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX61281.1 - 1.1e-09 38.4 6.5 1.1e-09 38.4 6.5 2.3 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX61281.1 - 3e-09 37.1 0.0 6e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 ORX61281.1 - 0.0043 17.2 0.3 6.5 7.0 0.1 2.9 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain KxDL PF10241.9 ORX61282.1 - 2e-05 24.8 4.6 2e-05 24.8 4.6 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein DUF2408 PF10303.9 ORX61282.1 - 0.026 15.1 5.7 1.9 9.0 3.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) PAE PF03283.13 ORX61282.1 - 0.027 13.6 1.4 0.039 13.1 1.4 1.2 1 0 0 1 1 1 0 Pectinacetylesterase USP8_interact PF08941.10 ORX61282.1 - 0.071 12.9 0.9 0.16 11.7 0.9 1.5 1 0 0 1 1 1 0 USP8 interacting DUF745 PF05335.13 ORX61282.1 - 0.15 11.7 6.2 0.052 13.3 3.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Osmo_CC PF08946.10 ORX61282.1 - 0.29 11.4 3.8 0.87 9.9 3.8 1.8 1 0 0 1 1 1 0 Osmosensory transporter coiled coil DUF4375 PF14300.6 ORX61282.1 - 0.34 11.2 3.6 0.54 10.5 2.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) Phage_GPO PF05929.11 ORX61282.1 - 0.75 9.4 5.9 0.44 10.1 2.9 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase WASH-7_C PF14746.6 ORX61282.1 - 0.76 9.4 4.8 1.6 8.4 4.8 1.5 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Baculo_PEP_C PF04513.12 ORX61282.1 - 0.98 9.5 7.1 0.38 10.8 2.9 2.3 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 ORX61282.1 - 3.5 6.9 7.4 0.24 10.7 1.8 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ORX61282.1 - 4.4 7.5 12.0 1.1 9.4 8.1 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Mit_KHE1 PF10173.9 ORX61283.1 - 1.6e-38 132.7 4.1 2.4e-38 132.2 4.1 1.3 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related Mitochondr_Som1 PF11093.8 ORX61284.1 - 2.9e-11 43.2 1.3 3.3e-11 43.0 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial export protein Som1 Multi-haem_cyto PF13447.6 ORX61285.1 - 0.047 12.9 0.2 0.097 11.9 0.2 1.4 1 0 0 1 1 1 0 Seven times multi-haem cytochrome CxxCH PI-PLC-X PF00388.19 ORX61285.1 - 0.053 13.1 0.1 3.7 7.1 0.0 2.5 2 0 0 2 2 2 0 Phosphatidylinositol-specific phospholipase C, X domain E1-E2_ATPase PF00122.20 ORX61285.1 - 0.14 11.7 0.3 1.9 8.0 0.1 2.2 2 0 0 2 2 2 0 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX61286.1 - 1.2e-06 28.4 14.8 1.3e-06 28.2 14.8 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Comm PF15957.5 ORX61286.1 - 0.029 14.7 3.2 0.029 14.7 3.2 2.4 1 1 1 2 2 2 0 Commissureless GRDP-like PF07173.12 ORX61287.1 - 0.00097 19.8 0.2 0.00097 19.8 0.2 2.1 3 0 0 3 3 3 1 Glycine-rich domain-containing protein-like Glucan_synthase PF02364.15 ORX61288.1 - 0 1100.7 0.6 0 1100.7 0.6 1.9 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ORX61288.1 - 3.6e-27 95.2 1.1 3.5e-26 92.0 1.1 2.6 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SNN_linker PF09050.10 ORX61288.1 - 0.059 13.1 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Stannin unstructured linker Mab-21 PF03281.14 ORX61289.1 - 0.006 15.9 0.0 0.007 15.7 0.0 1.1 1 0 0 1 1 1 1 Mab-21 protein LRRFIP PF09738.9 ORX61289.1 - 0.041 13.4 1.6 0.053 13.0 1.6 1.0 1 0 0 1 1 1 0 LRRFIP family p450 PF00067.22 ORX61290.1 - 1e-94 317.9 0.0 1.4e-94 317.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 FAD_binding_1 PF00667.20 ORX61290.1 - 1.4e-30 106.5 0.0 2.5e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX61290.1 - 3.5e-24 85.6 0.9 9.6e-24 84.2 0.9 1.8 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX61290.1 - 1.2e-14 54.9 0.0 3.9e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain zf-C2H2_aberr PF17017.5 ORX61291.1 - 4.5e-06 26.9 5.4 0.052 13.7 0.1 3.1 2 1 1 3 3 3 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ORX61291.1 - 1.8e-05 24.9 11.8 0.16 12.5 1.5 4.1 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ORX61291.1 - 5.7e-05 23.4 0.5 0.051 13.9 0.1 3.0 1 1 1 2 2 2 2 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ORX61291.1 - 0.00037 21.1 9.1 3.8 8.6 0.1 4.1 3 0 0 3 3 3 3 C2H2-type zinc finger FOXP-CC PF16159.5 ORX61291.1 - 5.9 7.6 0.0 3.4 8.4 0.9 4.3 4 1 1 5 5 5 0 FOXP coiled-coil domain Ribosomal_L23 PF00276.20 ORX61292.1 - 3.4e-18 65.8 0.1 5.8e-18 65.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 DUF2678 PF10856.8 ORX61292.1 - 0.035 14.1 0.0 0.046 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2678) BRCA2 PF00634.18 ORX61293.1 - 1.3 8.7 8.9 1.3 8.8 0.4 2.7 2 1 0 2 2 2 0 BRCA2 repeat BRCA-2_OB1 PF09103.10 ORX61294.1 - 5.4e-30 103.9 0.1 1.2e-29 102.8 0.1 1.6 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 BRCA-2_helical PF09169.10 ORX61294.1 - 4.9e-13 49.2 0.2 1.2e-12 47.9 0.2 1.6 1 0 0 1 1 1 1 BRCA2, helical Rep-A_N PF04057.12 ORX61294.1 - 0.016 15.2 1.4 0.033 14.2 0.1 2.2 3 0 0 3 3 3 0 Replication factor-A protein 1, N-terminal domain DAGAT PF03982.13 ORX61295.1 - 6.8e-90 301.0 0.0 8.9e-90 300.6 0.0 1.1 1 0 0 1 1 1 1 Diacylglycerol acyltransferase bZIP_1 PF00170.21 ORX61296.1 - 3.7e-09 36.5 10.8 3.7e-09 36.5 10.8 2.1 1 1 1 2 2 2 2 bZIP transcription factor bZIP_2 PF07716.15 ORX61296.1 - 6.8e-05 22.9 19.6 0.00062 19.8 9.3 2.9 1 1 2 3 3 3 3 Basic region leucine zipper DUF812 PF05667.11 ORX61296.1 - 6.9e-05 21.9 9.4 7.8e-05 21.8 9.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF148 PF02520.17 ORX61296.1 - 0.011 15.8 0.9 0.011 15.8 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF148 YabA PF06156.13 ORX61296.1 - 0.018 15.6 4.6 0.018 15.6 4.6 1.9 2 0 0 2 2 2 0 Initiation control protein YabA Macoilin PF09726.9 ORX61296.1 - 0.029 13.0 12.3 0.034 12.7 12.3 1.0 1 0 0 1 1 1 0 Macoilin family BESS PF02944.20 ORX61296.1 - 0.085 12.7 0.3 0.2 11.5 0.3 1.7 1 0 0 1 1 1 0 BESS motif TolA_bind_tri PF16331.5 ORX61296.1 - 0.24 11.5 9.6 0.74 9.9 9.6 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation ZapB PF06005.12 ORX61296.1 - 0.38 11.2 9.9 1.8 9.1 5.1 2.8 1 1 1 2 2 2 0 Cell division protein ZapB bZIP_Maf PF03131.17 ORX61296.1 - 1.1 9.8 17.8 0.054 14.0 10.5 2.6 2 2 0 2 2 2 0 bZIP Maf transcription factor Cnn_1N PF07989.11 ORX61296.1 - 1.9 8.7 11.1 2.1 8.5 8.5 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Ribosomal_S6 PF01250.17 ORX61297.1 - 0.013 15.7 0.3 1.1 9.6 0.1 3.0 2 0 0 2 2 2 0 Ribosomal protein S6 Fib_alpha PF08702.10 ORX61297.1 - 0.035 14.3 6.4 0.036 14.2 0.2 2.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Muted PF14942.6 ORX61297.1 - 0.037 14.4 0.1 0.037 14.4 0.1 3.0 3 0 0 3 3 3 0 Organelle biogenesis, Muted-like protein Phage_Mu_Gam PF07352.12 ORX61297.1 - 0.068 13.1 5.1 0.2 11.6 0.7 2.9 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein Baculo_PEP_C PF04513.12 ORX61297.1 - 0.088 12.8 3.5 22 5.1 0.0 4.0 4 0 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 ORX61297.1 - 0.15 11.6 2.0 6.5 6.2 0.1 2.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ORX61297.1 - 0.27 11.3 5.0 3.6 7.6 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 ORX61297.1 - 0.95 9.7 11.8 0.23 11.7 1.2 3.8 4 0 0 4 4 4 0 JNK-interacting protein leucine zipper II DUF4795 PF16043.5 ORX61297.1 - 0.97 9.0 11.6 0.25 10.9 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Med9 PF07544.13 ORX61297.1 - 1.1 9.5 11.1 1.1 9.5 5.6 3.1 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 APG6_N PF17675.1 ORX61297.1 - 1.2 9.7 12.9 0.33 11.5 1.6 3.6 3 0 0 3 3 3 0 Apg6 coiled-coil region CENP-H PF05837.12 ORX61297.1 - 1.3 9.4 10.5 5.9 7.3 5.2 3.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) HEAT PF02985.22 ORX61298.1 - 1.9e-13 49.4 2.3 0.0034 17.5 0.1 5.2 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 ORX61298.1 - 7.1e-12 45.6 0.9 1.2e-05 25.5 0.1 4.0 3 1 0 3 3 3 3 HEAT repeats HEAT_EZ PF13513.6 ORX61298.1 - 2.9e-11 43.6 5.8 0.00017 22.0 0.9 5.8 4 2 1 5 5 5 3 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ORX61298.1 - 0.023 15.3 0.2 34 5.1 0.0 3.5 2 2 2 4 4 4 0 Vacuolar 14 Fab1-binding region Arm PF00514.23 ORX61298.1 - 0.36 10.9 3.0 25 5.1 0.1 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Cohesin_HEAT PF12765.7 ORX61298.1 - 0.36 11.2 3.5 8.6 6.8 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion DUF4042 PF13251.6 ORX61298.1 - 0.44 10.2 2.2 22 4.7 0.1 3.4 2 2 1 4 4 4 0 Domain of unknown function (DUF4042) DUF4442 PF14539.6 ORX61299.1 - 7e-20 71.5 0.0 8.9e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4442) MTA_R1 PF17226.2 ORX61299.1 - 0.099 12.8 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 MTA R1 domain NFRKB_winged PF14465.6 ORX61300.1 - 0.19 12.0 3.2 0.17 12.1 1.6 1.8 2 0 0 2 2 2 0 NFRKB Winged Helix-like Ammonium_transp PF00909.21 ORX61301.1 - 4.6e-111 371.3 26.5 5.6e-111 371.0 26.5 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family BatA PF07584.11 ORX61302.1 - 0.014 15.8 0.7 0.048 14.0 0.6 2.0 1 1 0 1 1 1 0 Aerotolerance regulator N-terminal Methyltransf_25 PF13649.6 ORX61303.1 - 6.8e-07 29.9 0.0 2.3e-06 28.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ORX61303.1 - 9.8e-06 25.2 0.0 1.7e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ORX61303.1 - 3.4e-05 24.4 0.0 0.00012 22.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX61303.1 - 0.0004 20.3 0.0 0.0014 18.5 0.0 1.8 1 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ORX61303.1 - 0.0012 18.4 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ORX61303.1 - 0.0089 15.8 0.0 0.015 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ORX61303.1 - 0.011 15.4 0.0 0.34 10.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein 95 DREV PF05219.12 ORX61303.1 - 0.038 13.1 0.0 0.064 12.3 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase Thg1 PF04446.12 ORX61304.1 - 1.4e-54 183.5 0.2 2.4e-54 182.7 0.2 1.4 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 ORX61304.1 - 2.6e-41 140.6 0.2 4.1e-41 140.0 0.2 1.3 1 0 0 1 1 1 1 Thg1 C terminal domain Nop10p PF04135.12 ORX61305.1 - 3.5e-24 84.6 1.4 4e-24 84.4 1.4 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family Acetyltransf_1 PF00583.25 ORX61306.1 - 2.5e-09 37.4 0.0 3.5e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ORX61306.1 - 0.00051 20.0 0.0 0.0022 17.9 0.0 1.9 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_7 PF13508.7 ORX61306.1 - 0.0026 18.2 0.0 0.0037 17.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Ank_2 PF12796.7 ORX61307.1 - 1.6e-19 70.3 0.6 5.1e-11 43.0 0.1 2.5 2 2 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX61307.1 - 2.4e-12 45.9 2.0 0.0001 22.4 0.1 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ORX61307.1 - 4.1e-06 27.0 0.3 0.00078 19.7 0.2 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX61307.1 - 6.8e-06 26.5 0.1 0.00016 22.1 0.0 3.0 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank PF00023.30 ORX61307.1 - 2.6e-05 24.4 4.3 0.0068 16.8 0.3 4.6 5 1 0 5 5 5 1 Ankyrin repeat MLVIN_C PF18697.1 ORX61310.1 - 1.5e-05 25.0 0.1 3.4e-05 23.9 0.0 1.6 1 1 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain gag-asp_proteas PF13975.6 ORX61311.1 - 2e-08 34.6 0.0 2.5e-08 34.4 0.0 1.0 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ORX61311.1 - 2e-06 28.3 0.0 2.7e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Aspartyl protease RVP_2 PF08284.11 ORX61311.1 - 0.0031 17.3 0.0 0.0041 16.9 0.0 1.1 1 0 0 1 1 1 1 Retroviral aspartyl protease Crr6 PF08847.11 ORX61312.1 - 0.014 15.1 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Chlororespiratory reduction 6 VMA21 PF09446.10 ORX61313.1 - 0.12 12.5 2.3 0.28 11.3 2.3 1.9 1 1 0 1 1 1 0 VMA21-like domain Cyt-b5 PF00173.28 ORX61314.1 - 5.7e-19 68.0 0.0 7.6e-19 67.6 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF4436 PF14494.6 ORX61315.1 - 1e-23 84.0 0.1 1.8e-23 83.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4436) F-box-like PF12937.7 ORX61315.1 - 9.2e-07 28.7 0.8 1.8e-06 27.7 0.8 1.5 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.28 ORX61315.1 - 0.0023 17.7 0.0 0.0048 16.7 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61315.1 - 0.0043 17.1 0.1 0.01 15.9 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 ORX61315.1 - 0.014 15.5 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ORX61315.1 - 0.015 15.0 0.0 0.049 13.3 0.0 1.9 1 1 1 2 2 2 0 TPR repeat Aida_N PF08910.10 ORX61315.1 - 0.15 12.4 0.1 0.36 11.2 0.1 1.6 1 0 0 1 1 1 0 Aida N-terminus TPR_MalT PF17874.1 ORX61315.1 - 0.21 10.9 0.0 0.35 10.2 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region F-box PF00646.33 ORX61315.1 - 0.23 11.4 2.0 0.28 11.1 0.4 2.0 2 0 0 2 2 2 0 F-box domain BCDHK_Adom3 PF10436.9 ORX61316.1 - 2.3e-66 222.6 0.1 3.9e-66 221.9 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ORX61316.1 - 2.4e-08 34.5 0.0 4.2e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ORX61316.1 - 9.9e-05 22.2 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DPBB_1 PF03330.18 ORX61317.1 - 3.1e-10 40.2 0.0 1.1e-09 38.5 0.0 2.0 1 1 0 1 1 1 1 Lytic transglycolase Dicty_REP PF05086.12 ORX61317.1 - 0.0084 14.1 6.7 0.011 13.8 6.7 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein zf-ribbon_3 PF13248.6 ORX61317.1 - 0.14 11.6 6.2 4.6 6.8 0.4 3.3 4 0 0 4 4 4 0 zinc-ribbon domain ETS_PEA3_N PF04621.13 ORX61317.1 - 0.21 11.4 1.3 0.29 11.0 1.3 1.2 1 0 0 1 1 1 0 PEA3 subfamily ETS-domain transcription factor N terminal domain Mucin PF01456.17 ORX61317.1 - 0.6 10.1 42.6 0.21 11.6 36.2 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2367 PF10164.9 ORX61317.1 - 3.4 8.2 5.7 23 5.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2367) Vac14_Fab1_bd PF12755.7 ORX61318.1 - 7.4e-05 23.3 1.7 0.0089 16.6 0.2 2.3 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region V-ATPase_H_C PF11698.8 ORX61318.1 - 9.5e-05 22.5 0.4 9.5e-05 22.5 0.4 1.6 2 0 0 2 2 2 1 V-ATPase subunit H Atx10homo_assoc PF09759.9 ORX61318.1 - 0.0021 18.1 0.9 0.0037 17.3 0.5 1.7 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Proteasom_PSMB PF10508.9 ORX61318.1 - 0.0082 14.7 0.8 0.0098 14.4 0.8 1.1 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit WAPL PF07814.13 ORX61318.1 - 0.039 12.8 0.1 0.067 12.0 0.1 1.3 1 0 0 1 1 1 0 Wings apart-like protein regulation of heterochromatin HEAT PF02985.22 ORX61318.1 - 0.069 13.4 0.1 0.53 10.7 0.1 2.5 2 0 0 2 2 2 0 HEAT repeat RsfS PF02410.15 ORX61320.1 - 2.8e-22 79.0 0.0 3.9e-22 78.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation DUF2750 PF11042.8 ORX61320.1 - 0.037 14.1 0.5 0.073 13.1 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2750) Flot PF15975.5 ORX61320.1 - 0.13 12.5 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Flotillin MAT1 PF06391.13 ORX61321.1 - 0.65 9.8 15.7 0.66 9.8 15.7 1.0 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 DUF3043 PF11241.8 ORX61321.1 - 7.8 6.5 9.1 7.9 6.5 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) AAA PF00004.29 ORX61322.1 - 1.6e-30 106.2 0.0 1.4e-28 99.9 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX61322.1 - 7.1e-07 28.9 0.4 1.9e-06 27.6 0.0 1.9 2 0 0 2 2 1 1 AAA+ lid domain AAA_33 PF13671.6 ORX61322.1 - 1.7e-05 25.0 0.0 3.2e-05 24.1 0.0 1.6 2 1 0 2 2 1 1 AAA domain AAA_16 PF13191.6 ORX61322.1 - 3.7e-05 24.2 0.2 0.0012 19.2 0.2 2.8 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 ORX61322.1 - 6.5e-05 22.7 0.0 0.00015 21.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ORX61322.1 - 9.7e-05 22.2 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 ORX61322.1 - 0.00024 20.4 0.1 0.00048 19.4 0.0 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 ORX61322.1 - 0.0004 20.7 0.1 0.0014 18.9 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX61322.1 - 0.00052 20.6 0.0 0.00083 19.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX61322.1 - 0.0026 17.3 0.1 0.0057 16.2 0.0 1.5 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 ORX61322.1 - 0.003 17.4 0.1 0.0036 17.1 0.1 1.4 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX61322.1 - 0.0098 16.3 0.0 0.025 15.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ORX61322.1 - 0.01 15.2 0.0 0.034 13.4 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin AAA_7 PF12775.7 ORX61322.1 - 0.012 15.1 0.0 0.035 13.6 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 ORX61322.1 - 0.015 14.7 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 ORX61322.1 - 0.018 15.6 0.1 0.11 12.9 0.1 2.0 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ORX61322.1 - 0.019 15.0 0.0 0.039 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ORX61322.1 - 0.019 15.0 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX61322.1 - 0.025 14.5 0.0 0.075 12.9 0.0 1.8 1 1 1 2 2 2 0 NACHT domain AAA_28 PF13521.6 ORX61322.1 - 0.029 14.6 0.3 0.07 13.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_2 PF07724.14 ORX61322.1 - 0.032 14.3 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) TsaE PF02367.17 ORX61322.1 - 0.034 14.1 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Hydin_ADK PF17213.3 ORX61322.1 - 0.038 14.3 0.0 0.08 13.2 0.0 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF815 PF05673.13 ORX61322.1 - 0.042 13.0 0.0 3.9 6.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ResIII PF04851.15 ORX61322.1 - 0.05 13.6 0.0 0.076 13.0 0.0 1.5 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ORX61322.1 - 0.053 13.2 0.2 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX61322.1 - 0.053 13.9 0.0 0.098 13.1 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 ORX61322.1 - 0.061 12.7 0.0 0.096 12.0 0.0 1.4 1 0 0 1 1 1 0 KaiC Rad17 PF03215.15 ORX61322.1 - 0.11 12.5 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain Cytidylate_kin PF02224.18 ORX61322.1 - 0.12 12.1 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NB-ARC PF00931.22 ORX61322.1 - 0.15 11.2 0.0 14 4.8 0.0 2.1 2 0 0 2 2 2 0 NB-ARC domain DUF2075 PF09848.9 ORX61322.1 - 0.16 11.2 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 ORX61323.1 - 1.2e-07 32.2 0.1 1.8e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 ORX61323.1 - 1.5e-06 27.7 0.0 1.7e-06 27.5 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 ORX61323.1 - 8.3e-05 22.4 0.0 8.8e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ORX61323.1 - 0.00024 21.3 0.0 0.00037 20.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ORX61323.1 - 0.00055 19.9 0.1 0.0011 18.9 0.0 1.5 2 0 0 2 2 2 1 NACHT domain CPT PF07931.12 ORX61323.1 - 0.00088 19.2 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 ORX61323.1 - 0.0011 19.3 0.0 0.0012 19.3 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 ORX61323.1 - 0.004 16.9 0.0 0.0044 16.8 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 ORX61323.1 - 0.0045 17.0 0.0 0.0065 16.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Hydin_ADK PF17213.3 ORX61323.1 - 0.0049 17.2 0.1 0.0068 16.7 0.1 1.2 1 0 0 1 1 1 1 Hydin Adenylate kinase-like domain Parvo_NS1 PF01057.17 ORX61323.1 - 0.0061 15.7 0.0 0.007 15.5 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 ORX61323.1 - 0.0099 15.2 0.0 0.011 15.0 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin AAA_18 PF13238.6 ORX61323.1 - 0.013 16.1 0.0 0.016 15.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ORX61323.1 - 0.015 15.3 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 ORX61323.1 - 0.024 14.3 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 ORX61323.1 - 0.045 12.9 0.1 0.068 12.3 0.1 1.3 1 1 0 1 1 1 0 NB-ARC domain AAA_17 PF13207.6 ORX61323.1 - 0.047 14.1 0.0 0.061 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ORX61323.1 - 0.054 12.9 0.1 0.074 12.4 0.1 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IPT PF01745.16 ORX61323.1 - 0.057 12.8 0.1 0.11 11.9 0.1 1.5 1 1 0 1 1 1 0 Isopentenyl transferase RNA_helicase PF00910.22 ORX61323.1 - 0.061 13.7 0.0 0.092 13.1 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ORX61323.1 - 0.062 13.0 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ORX61323.1 - 0.065 12.8 0.0 0.075 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ORX61323.1 - 0.077 12.2 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ORX61323.1 - 0.084 13.1 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX61323.1 - 0.1 12.3 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ORX61323.1 - 0.12 11.5 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DnaB_C PF03796.15 ORX61323.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Viral_helicase1 PF01443.18 ORX61323.1 - 0.16 11.7 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 ORX61323.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 ORX61323.1 - 0.17 11.2 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.16 ORX61323.1 - 0.18 11.2 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 PhoH-like protein Torsin PF06309.11 ORX61323.1 - 0.19 11.8 0.0 0.22 11.6 0.0 1.1 1 0 0 1 1 1 0 Torsin ABC_tran PF00005.27 ORX61323.1 - 0.26 11.8 0.4 0.41 11.1 0.4 1.3 1 0 0 1 1 1 0 ABC transporter MFS_1 PF07690.16 ORX61325.1 - 6.4e-05 22.0 26.4 6.4e-05 22.0 26.4 2.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Pro_dh PF01619.18 ORX61327.1 - 4.8e-73 246.3 0.0 1.8e-72 244.4 0.0 1.8 1 1 0 1 1 1 1 Proline dehydrogenase T5orf172 PF10544.9 ORX61328.1 - 8.4e-16 58.4 0.1 1.5e-15 57.6 0.1 1.4 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 ORX61328.1 - 4.8e-14 52.8 0.2 9.7e-14 51.8 0.2 1.5 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 Gpi1 PF05024.15 ORX61329.1 - 3.8e-69 232.5 12.2 9.4e-69 231.2 12.2 1.7 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) DUF2183 PF09949.9 ORX61330.1 - 8.6e-31 106.2 0.0 1e-29 102.8 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) DUF4200 PF13863.6 ORX61331.1 - 0.0036 17.7 17.2 0.0036 17.7 17.2 3.4 2 1 1 3 3 3 1 Domain of unknown function (DUF4200) GIT_CC PF16559.5 ORX61331.1 - 0.0075 16.1 0.7 0.0075 16.1 0.7 3.4 3 0 0 3 3 3 1 GIT coiled-coil Rho guanine nucleotide exchange factor Laminin_II PF06009.12 ORX61331.1 - 0.039 14.0 0.8 0.039 14.0 0.8 2.8 2 1 1 3 3 3 0 Laminin Domain II Mst1_SARAH PF11629.8 ORX61331.1 - 0.06 13.4 7.3 0.26 11.4 0.4 3.1 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 DUF812 PF05667.11 ORX61331.1 - 0.082 11.8 24.8 0.11 11.4 24.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HalX PF08663.10 ORX61331.1 - 0.7 10.3 9.6 1.3 9.4 0.7 2.8 2 0 0 2 2 2 0 HalX domain DUF4472 PF14739.6 ORX61331.1 - 0.98 10.2 28.0 0.081 13.7 9.2 3.5 3 1 1 4 4 3 0 Domain of unknown function (DUF4472) TPR_MLP1_2 PF07926.12 ORX61331.1 - 1.2 9.2 25.5 0.15 12.1 9.8 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ORX61331.1 - 5.3 5.8 28.1 0.044 12.7 7.9 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1492 PF07374.11 ORX61331.1 - 6.4 7.0 11.3 0.2 11.8 2.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1492) FAM184 PF15665.5 ORX61331.1 - 6.6 6.5 30.4 2.6 7.8 27.0 2.0 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B DUF5595 PF18077.1 ORX61331.1 - 8.4 6.6 16.1 2.2 8.4 3.8 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5595) GDA1_CD39 PF01150.17 ORX61332.1 - 4.8e-119 397.8 0.0 7.1e-119 397.2 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family DUF4381 PF14316.6 ORX61332.1 - 0.077 13.2 0.1 0.077 13.2 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Phage_holin_2_4 PF16082.5 ORX61332.1 - 0.28 10.9 0.9 1.6 8.5 0.2 2.3 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Zn_clus PF00172.18 ORX61333.1 - 4.4e-08 33.1 9.7 8.7e-08 32.2 9.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 ORX61333.1 - 1.1e-07 31.2 5.2 1.1e-07 31.2 5.2 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain SUIM_assoc PF16619.5 ORX61333.1 - 4.6 7.4 8.4 4.8 7.3 4.1 2.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 UIM PF02809.20 ORX61335.1 - 0.043 13.7 1.0 0.13 12.3 1.0 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif OB_Dis3 PF17849.1 ORX61338.1 - 5.3e-05 23.2 0.0 9.1e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 ORX61338.1 - 0.0016 18.2 2.5 0.0062 16.3 2.5 1.8 1 1 0 1 1 1 1 Rrp44-like cold shock domain Ferric_reduct PF01794.19 ORX61340.1 - 2e-08 34.4 13.2 2e-08 34.4 13.2 3.1 2 1 1 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ORX61340.1 - 7.7e-08 32.6 0.0 5e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ORX61340.1 - 0.00051 20.7 0.0 0.0011 19.6 0.0 1.6 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_8 PF08022.12 ORX61340.1 - 0.037 14.1 0.0 0.17 12.0 0.0 2.0 1 1 0 1 1 1 0 FAD-binding domain Sel1 PF08238.12 ORX61341.1 - 3.9e-40 135.4 15.7 1.7e-05 25.3 0.3 7.4 7 0 0 7 7 7 7 Sel1 repeat EamA PF00892.20 ORX61342.1 - 5.3e-09 36.4 27.5 6.3e-07 29.6 15.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family SLC35F PF06027.12 ORX61342.1 - 0.01 15.4 7.4 0.031 13.8 7.5 1.7 1 1 0 1 1 1 0 Solute carrier family 35 DUF3180 PF11377.8 ORX61342.1 - 0.011 15.9 4.9 0.012 15.7 0.0 2.7 2 1 2 4 4 4 0 Protein of unknown function (DUF3180) YtpI PF14007.6 ORX61342.1 - 0.033 14.3 1.7 0.033 14.3 1.7 2.4 2 1 1 3 3 3 0 YtpI-like protein DUF2371 PF10177.9 ORX61342.1 - 0.93 9.7 2.8 3.4 7.9 0.1 2.5 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) Nuc_sug_transp PF04142.15 ORX61342.1 - 1.2 8.3 8.8 8.5 5.4 8.8 1.9 1 1 0 1 1 1 0 Nucleotide-sugar transporter WD40 PF00400.32 ORX61343.1 - 7.8e-12 45.5 0.4 0.00029 21.6 0.0 4.8 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61343.1 - 0.0067 16.7 0.2 22 5.4 0.0 4.2 2 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SRP9-21 PF05486.12 ORX61343.1 - 0.017 15.5 2.0 0.041 14.3 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) Nucleoporin_N PF08801.11 ORX61343.1 - 0.02 13.7 0.3 0.37 9.5 0.0 2.6 2 1 0 2 2 2 0 Nup133 N terminal like adh_short PF00106.25 ORX61344.1 - 4.8e-36 124.1 0.1 6.1e-36 123.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX61344.1 - 1.5e-22 80.3 0.0 2.3e-22 79.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX61344.1 - 1.8e-09 37.8 0.1 2.6e-09 37.2 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX61344.1 - 5.2e-05 22.8 0.2 0.00021 20.9 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX61344.1 - 0.0035 16.8 0.1 0.0047 16.4 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Transferase PF02458.15 ORX61344.1 - 0.068 11.8 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Transferase family Motile_Sperm PF00635.26 ORX61345.1 - 4.4e-25 87.6 0.5 6.9e-25 87.0 0.5 1.3 1 0 0 1 1 1 1 MSP (Major sperm protein) domain ASH PF15780.5 ORX61345.1 - 0.0087 16.2 0.1 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin YebO PF13974.6 ORX61345.1 - 0.099 12.7 2.0 0.26 11.4 2.0 1.7 1 0 0 1 1 1 0 YebO-like protein HIP1_clath_bdg PF16515.5 ORX61345.1 - 0.11 13.2 0.4 0.18 12.4 0.4 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF953 PF06110.11 ORX61346.1 - 1.4e-22 79.5 0.0 1.6e-22 79.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) DIM1 PF02966.16 ORX61346.1 - 0.0031 17.3 0.0 0.0039 17.0 0.0 1.3 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_9 PF14595.6 ORX61346.1 - 0.027 14.2 0.3 0.04 13.7 0.3 1.4 1 1 0 1 1 1 0 Thioredoxin Cyto_heme_lyase PF01265.17 ORX61347.1 - 4.3e-73 246.5 15.7 2.3e-72 244.0 15.7 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase Forkhead PF00250.18 ORX61350.1 - 2e-30 104.8 1.2 2.2e-30 104.7 1.2 1.0 1 0 0 1 1 1 1 Forkhead domain IpaB_EvcA PF03278.13 ORX61350.1 - 0.053 13.2 0.0 0.06 13.1 0.0 1.1 1 0 0 1 1 1 0 IpaB/EvcA family OST-HTH PF12872.7 ORX61350.1 - 0.082 12.7 0.0 0.18 11.6 0.0 1.5 2 0 0 2 2 2 0 OST-HTH/LOTUS domain DUF3818 PF12825.7 ORX61351.1 - 2.7e-86 289.7 0.3 7.5e-86 288.2 0.3 1.8 1 1 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 ORX61351.1 - 5.7e-14 52.2 5.9 2.7e-12 46.8 3.5 2.9 2 1 0 2 2 2 1 PX-associated PX PF00787.24 ORX61351.1 - 2e-11 43.9 0.1 4.7e-11 42.7 0.1 1.7 1 0 0 1 1 1 1 PX domain Pkinase PF00069.25 ORX61352.1 - 4.4e-40 137.7 0.0 1.6e-19 70.3 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61352.1 - 2.7e-10 40.0 0.0 5.5e-05 22.6 0.0 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ORX61352.1 - 0.0013 18.7 0.3 0.03 14.2 0.1 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX61352.1 - 0.0019 17.0 0.0 0.0039 16.0 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase RIO1 PF01163.22 ORX61352.1 - 0.033 13.8 0.0 0.072 12.7 0.0 1.6 1 0 0 1 1 1 0 RIO1 family BEN PF10523.9 ORX61352.1 - 0.12 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 BEN domain Haspin_kinase PF12330.8 ORX61352.1 - 0.15 11.0 0.0 0.2 10.6 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Methyltransf_21 PF05050.12 ORX61353.1 - 2.9e-06 27.4 0.1 6.3e-06 26.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase FkbM domain VIR_N PF15912.5 ORX61353.1 - 7.8 6.0 9.0 14 5.2 9.0 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Mito_fiss_reg PF05308.11 ORX61353.1 - 8.5 6.4 7.4 13 5.7 7.4 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator Prok-RING_4 PF14447.6 ORX61354.1 - 0.028 14.3 11.1 0.19 11.6 6.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 WD40 PF00400.32 ORX61355.1 - 8.1e-15 55.0 4.2 0.00015 22.5 0.1 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61355.1 - 1.9e-08 34.5 0.0 0.0026 18.0 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ORX61355.1 - 0.0012 17.5 0.0 0.002 16.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain eIF2A PF08662.11 ORX61355.1 - 0.018 14.9 0.0 0.086 12.7 0.0 1.9 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ORX61355.1 - 0.024 14.6 1.0 0.96 9.5 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Y_phosphatase3 PF13350.6 ORX61357.1 - 9.8e-43 146.8 0.0 1.2e-42 146.5 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ORX61357.1 - 9.2e-05 22.1 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ORX61357.1 - 0.0026 17.4 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX61357.1 - 0.0056 16.5 0.1 0.0097 15.7 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain LRR_6 PF13516.6 ORX61358.1 - 4.6e-07 29.4 0.1 0.48 10.6 0.0 5.0 5 0 0 5 5 5 3 Leucine Rich repeat LRR_4 PF12799.7 ORX61358.1 - 0.00082 19.7 0.0 0.19 12.2 0.0 3.5 3 1 0 3 3 3 1 Leucine Rich repeats (2 copies) DUF1699 PF08004.11 ORX61358.1 - 0.027 14.1 0.7 1.4 8.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1699) AT_hook PF02178.19 ORX61359.1 - 0.00037 20.1 13.1 0.29 11.1 4.8 4.3 2 0 0 2 2 2 2 AT hook motif HC2 PF07382.11 ORX61359.1 - 0.063 13.4 47.9 0.09 12.8 47.9 1.3 1 0 0 1 1 1 0 Histone H1-like nucleoprotein HC2 zf-C2H2_6 PF13912.6 ORX61359.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Mitofilin PF09731.9 ORX61359.1 - 1.5 7.5 28.3 1.7 7.4 28.3 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein UCMA PF17085.5 ORX61359.1 - 6.7 6.7 8.3 1.3 9.1 3.7 2.1 1 1 2 3 3 3 0 Unique cartilage matrix associated protein Proteasome PF00227.26 ORX61360.1 - 1.7e-48 164.7 0.0 2e-48 164.4 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Glycos_transf_1 PF00534.20 ORX61361.1 - 1.3e-24 86.7 0.0 3.8e-23 81.9 0.0 2.7 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ORX61361.1 - 7.4e-21 75.0 0.0 3.8e-20 72.7 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ORX61361.1 - 3.5e-18 66.2 0.1 5.7e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ORX61361.1 - 2.5e-10 41.0 0.0 5.2e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 ORX61361.1 - 0.001 19.4 0.0 0.0031 17.9 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferases group 1 FYRN PF05964.14 ORX61362.1 - 1.5e-18 66.4 1.1 1.5e-18 66.4 1.1 2.0 2 0 0 2 2 2 1 F/Y-rich N-terminus FYRC PF05965.14 ORX61362.1 - 2.4e-14 53.3 0.0 4.6e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus Acetyltransf_1 PF00583.25 ORX61363.1 - 1.2e-06 28.7 0.0 1.9e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX61363.1 - 4.6e-06 26.6 0.0 8.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX61363.1 - 1.9e-05 25.0 0.0 4.7e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX61363.1 - 0.065 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 FR47-like protein tRNA-synt_2d PF01409.20 ORX61364.1 - 3.7e-48 164.2 1.1 7.6e-28 97.6 0.1 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ORX61364.1 - 3e-23 82.1 0.0 7.5e-23 80.8 0.0 1.7 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2 PF00152.20 ORX61364.1 - 0.024 13.7 0.1 3.9 6.5 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II (D, K and N) Cupin_8 PF13621.6 ORX61365.1 - 1.2e-77 261.1 0.1 1.4e-77 260.9 0.1 1.0 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ORX61365.1 - 0.0013 19.1 0.6 0.034 14.6 0.0 2.8 2 2 1 3 3 3 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 ORX61365.1 - 0.18 11.2 0.1 0.36 10.2 0.0 1.5 2 0 0 2 2 2 0 Cupin superfamily protein GDPD PF03009.17 ORX61366.1 - 9.8e-64 215.6 0.0 2e-63 214.5 0.0 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 ORX61366.1 - 3.9e-27 94.7 2.1 1e-14 54.9 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX61366.1 - 6.7e-21 74.4 0.5 1.2e-07 32.1 0.0 4.7 4 1 0 4 4 4 3 Ankyrin repeats (many copies) SPX PF03105.19 ORX61366.1 - 9.9e-19 68.5 13.2 2.4e-08 34.3 0.1 4.2 2 1 2 4 4 4 3 SPX domain Ank_5 PF13857.6 ORX61366.1 - 8.5e-18 64.2 2.1 2.3e-07 31.0 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX61366.1 - 8e-17 59.6 0.6 0.00033 20.9 0.0 6.8 7 0 0 7 7 7 3 Ankyrin repeat Ank PF00023.30 ORX61366.1 - 7.5e-14 51.5 5.6 1.4e-05 25.3 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat PI-PLC-X PF00388.19 ORX61366.1 - 0.14 11.8 0.0 0.36 10.4 0.0 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Sporozoite_P67 PF05642.11 ORX61366.1 - 3 5.8 6.2 0.87 7.6 0.4 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen SWIM PF04434.17 ORX61368.1 - 0.11 12.2 0.4 0.24 11.1 0.4 1.5 1 0 0 1 1 1 0 SWIM zinc finger PIF2 PF04631.12 ORX61369.1 - 0.088 11.6 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Per os infectivity factor 2 Pkinase PF00069.25 ORX61370.1 - 1.2e-65 221.5 0.0 1.7e-65 221.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61370.1 - 8.9e-48 162.8 0.0 1.5e-47 162.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61370.1 - 1.5e-05 24.4 0.0 0.001 18.5 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ORX61370.1 - 1.6e-05 23.9 0.0 2.6e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Ras_bdg_2 PF14847.6 ORX61370.1 - 2.4e-05 24.6 0.0 4.5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Ras-binding domain of Byr2 Kdo PF06293.14 ORX61370.1 - 0.025 13.9 0.0 0.11 11.8 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX61370.1 - 0.05 13.5 0.1 4.2 7.2 0.1 2.3 1 1 0 2 2 2 0 Phosphotransferase enzyme family RhoGAP PF00620.27 ORX61371.1 - 1.1e-39 135.7 0.0 1.1e-39 135.7 0.0 2.1 3 0 0 3 3 3 1 RhoGAP domain FCH PF00611.23 ORX61371.1 - 0.083 13.2 0.1 0.083 13.2 0.1 2.1 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Glyco_hydro_20 PF00728.22 ORX61372.1 - 3.9e-82 276.5 0.3 5.9e-80 269.3 0.3 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ORX61372.1 - 1.2e-18 68.1 0.1 2.1e-18 67.3 0.1 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ORX61372.1 - 0.0013 19.6 0.0 0.0026 18.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 DUF3218 PF11508.8 ORX61372.1 - 0.0015 18.1 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3218) COG2 PF06148.11 ORX61373.1 - 1.4e-30 106.1 3.0 1.4e-30 106.1 3.0 2.8 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3510 PF12022.8 ORX61373.1 - 1.5e-30 106.1 0.4 7.8e-30 103.9 0.0 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3510) Vps51 PF08700.11 ORX61373.1 - 0.00023 21.2 0.6 0.0013 18.7 0.0 2.7 2 0 0 2 2 2 1 Vps51/Vps67 FAM184 PF15665.5 ORX61373.1 - 0.07 12.9 6.0 0.08 12.7 2.9 2.4 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF1664 PF07889.12 ORX61373.1 - 0.099 12.7 5.1 0.082 13.0 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) NPA PF16469.5 ORX61373.1 - 0.12 12.9 0.6 3.6 8.2 0.1 3.0 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 DUF520 PF04461.13 ORX61373.1 - 0.19 11.9 4.1 0.11 12.7 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF520) NPV_P10 PF05531.12 ORX61373.1 - 2.4 8.7 6.9 5.9 7.4 1.3 3.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein MT-A70 PF05063.14 ORX61374.1 - 6.7e-12 45.7 0.1 1.2e-11 44.8 0.1 1.4 1 0 0 1 1 1 1 MT-A70 DUF3455 PF11937.8 ORX61375.1 - 9.2e-07 29.4 0.1 1.2e-06 29.0 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) URO-D PF01208.17 ORX61377.1 - 3.7e-128 427.5 0.0 4.2e-128 427.3 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Pkinase PF00069.25 ORX61378.1 - 2.6e-44 151.6 0.0 3.5e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61378.1 - 2.4e-25 89.3 0.0 2.9e-25 89.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61378.1 - 0.00026 20.4 0.0 0.00034 20.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.11 ORX61378.1 - 0.0093 15.0 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 ORX61378.1 - 0.028 14.3 0.1 0.05 13.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX61378.1 - 0.03 13.7 0.4 0.046 13.1 0.4 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Na_H_Exchanger PF00999.21 ORX61379.1 - 8e-55 186.2 43.5 1.1e-54 185.8 43.5 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family EF-hand_1 PF00036.32 ORX61380.1 - 2.1e-19 67.5 2.7 1.5e-05 24.2 0.0 3.6 3 0 0 3 3 3 3 EF hand EF-hand_5 PF13202.6 ORX61380.1 - 3.1e-17 61.2 1.3 0.00027 20.3 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ORX61380.1 - 1.6e-16 58.7 2.5 0.00029 20.5 0.1 3.9 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 ORX61380.1 - 8.7e-16 58.1 3.0 0.0002 21.7 0.1 3.7 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ORX61380.1 - 7.9e-13 48.0 2.2 0.001 18.9 0.1 3.5 2 1 1 3 3 3 3 EF-hand domain pair ZZ PF00569.17 ORX61380.1 - 1.9e-10 40.4 7.4 3.3e-10 39.6 7.4 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type Caleosin PF05042.13 ORX61380.1 - 0.0023 17.9 4.8 0.1 12.6 0.0 4.1 4 1 1 5 5 5 1 Caleosin related protein SPARC_Ca_bdg PF10591.9 ORX61380.1 - 0.0095 16.2 2.7 3.5 8.0 0.0 3.6 3 1 1 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region C1_2 PF03107.16 ORX61380.1 - 0.023 15.0 3.1 0.043 14.1 3.1 1.4 1 0 0 1 1 1 0 C1 domain DUF3752 PF12572.8 ORX61381.1 - 4.5e-27 95.4 15.6 4.5e-27 95.4 15.6 2.7 3 1 1 4 4 4 1 Protein of unknown function (DUF3752) IMUP PF15761.5 ORX61382.1 - 5.5 7.7 14.1 10 6.9 8.5 2.2 1 1 1 2 2 2 0 Immortalisation up-regulated protein Glyco_transf_49 PF13896.6 ORX61383.1 - 2.8e-63 214.3 1.9 7.5e-50 170.1 1.2 2.1 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_tranf_2_4 PF13704.6 ORX61383.1 - 0.087 13.3 0.3 0.25 11.9 0.3 1.8 1 0 0 1 1 1 0 Glycosyl transferase family 2 Ins134_P3_kin_N PF17927.1 ORX61383.1 - 0.088 13.2 0.0 9 6.8 0.0 2.6 2 0 0 2 2 2 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain SAM_decarbox PF01536.16 ORX61384.1 - 7.3e-124 413.4 0.0 1.3e-123 412.6 0.0 1.4 1 1 0 1 1 1 1 Adenosylmethionine decarboxylase zf-C2H2 PF00096.26 ORX61385.1 - 1.2e-15 56.9 7.9 1.8e-07 31.2 0.3 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX61385.1 - 1.3e-10 41.2 16.6 6.5e-08 32.7 0.8 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX61385.1 - 6.1e-10 39.1 7.4 1.8e-05 25.2 2.0 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX61385.1 - 4.5e-05 23.6 1.6 0.0046 17.2 0.4 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX61385.1 - 0.00056 19.6 14.4 0.021 14.5 0.5 3.0 3 1 0 3 3 3 2 C2H2-type zinc-finger domain zf-BED PF02892.15 ORX61385.1 - 0.0014 18.6 2.9 0.016 15.2 0.6 2.2 2 0 0 2 2 2 1 BED zinc finger zf-C2H2_6 PF13912.6 ORX61385.1 - 0.0015 18.5 6.0 0.076 13.0 1.0 2.3 2 1 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX61385.1 - 0.0022 18.4 2.0 0.017 15.5 0.4 2.3 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ORX61385.1 - 0.0063 16.3 5.1 0.12 12.2 0.2 2.2 2 0 0 2 2 2 2 zinc-finger C2H2-type Lung_7-TM_R PF06814.13 ORX61386.1 - 7.8e-69 232.1 18.1 9.9e-69 231.8 18.1 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor CoA_binding_3 PF13727.6 ORX61386.1 - 0.00096 19.2 0.1 0.0024 17.9 0.1 1.6 1 0 0 1 1 1 1 CoA-binding domain DUF3671 PF12420.8 ORX61386.1 - 0.25 11.4 1.2 0.75 9.9 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function Sorting_nexin PF03700.13 ORX61386.1 - 0.29 11.7 3.3 0.17 12.5 1.6 1.4 1 1 0 1 1 1 0 Sorting nexin, N-terminal domain DUF2140 PF09911.9 ORX61386.1 - 9.8 5.7 6.6 2.1 7.8 0.0 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) AAA_18 PF13238.6 ORX61387.1 - 1.3e-07 32.2 0.0 1.1e-06 29.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 ORX61387.1 - 0.00018 21.3 0.0 0.00054 19.7 0.0 1.8 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 ORX61387.1 - 0.0032 17.6 0.1 0.019 15.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX61387.1 - 0.0047 17.2 2.1 0.051 13.8 0.1 3.0 1 1 2 3 3 3 1 AAA domain AAA_16 PF13191.6 ORX61387.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Cytidylate_kin PF02224.18 ORX61387.1 - 0.016 15.0 0.1 0.1 12.3 0.1 2.2 1 1 0 1 1 1 0 Cytidylate kinase CoaE PF01121.20 ORX61387.1 - 0.076 12.7 0.4 0.18 11.5 0.1 1.7 2 0 0 2 2 2 0 Dephospho-CoA kinase ABC_tran PF00005.27 ORX61387.1 - 0.082 13.4 0.1 0.17 12.4 0.1 1.5 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 ORX61387.1 - 0.096 11.7 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TetR_C_28 PF17937.1 ORX61387.1 - 0.099 13.1 0.6 0.21 12.1 0.2 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain PPR_2 PF13041.6 ORX61388.1 - 4.3e-19 68.4 0.0 1.3e-10 41.3 0.1 4.5 5 0 0 5 5 5 2 PPR repeat family PPR_3 PF13812.6 ORX61388.1 - 1.2e-12 47.7 0.0 8.5e-08 32.2 0.0 4.8 5 1 1 6 6 6 3 Pentatricopeptide repeat domain PPR PF01535.20 ORX61388.1 - 1.6e-08 34.3 3.2 0.029 14.6 0.0 5.2 4 1 0 4 4 4 2 PPR repeat PPR_1 PF12854.7 ORX61388.1 - 3.3e-08 33.1 6.2 0.0069 16.1 0.1 4.6 4 1 0 4 4 4 3 PPR repeat PPR_long PF17177.4 ORX61388.1 - 2.3e-06 27.1 0.1 8.5e-06 25.3 0.0 1.9 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF1178 PF06676.11 ORX61390.1 - 0.0097 16.3 2.7 0.0097 16.3 2.7 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF1178) zf-met PF12874.7 ORX61390.1 - 0.01 16.2 0.9 0.014 15.8 0.1 1.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX61390.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ORX61390.1 - 0.12 12.7 1.0 0.33 11.3 1.0 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) FA_desaturase PF00487.24 ORX61391.1 - 2e-31 109.8 26.4 3.1e-31 109.2 26.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 ORX61391.1 - 1.4e-12 47.6 0.1 2.7e-12 46.6 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain LisH_TPL PF17814.1 ORX61391.1 - 0.18 11.5 0.0 0.48 10.1 0.0 1.7 1 0 0 1 1 1 0 LisH-like dimerisation domain SCP2 PF02036.17 ORX61392.1 - 0.05 14.1 0.0 0.062 13.8 0.0 1.1 1 0 0 1 1 1 0 SCP-2 sterol transfer family RRM_1 PF00076.22 ORX61394.1 - 1.4e-31 108.1 0.1 3.1e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX61394.1 - 7.4e-06 25.9 0.0 0.00012 22.0 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ORX61394.1 - 7.8e-05 22.7 0.0 0.045 13.9 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif RRM_Rrp7 PF17799.1 ORX61394.1 - 0.051 13.4 0.0 1.3 8.8 0.0 2.5 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain RR_TM4-6 PF06459.12 ORX61394.1 - 0.69 9.7 27.5 1.8 8.3 16.5 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF5427 PF10310.9 ORX61394.1 - 9.5 5.1 23.3 0.022 13.7 8.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Oxysterol_BP PF01237.18 ORX61395.1 - 2.9e-63 214.0 0.1 3.6e-61 207.0 0.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein GSIII_N PF12437.8 ORX61396.1 - 1.4e-66 223.1 0.1 2.4e-66 222.4 0.1 1.4 1 0 0 1 1 1 1 Glutamine synthetase type III N terminal Gln-synt_C-ter PF18318.1 ORX61396.1 - 2.4e-40 137.1 0.0 4.2e-40 136.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain Gln-synt_C PF00120.24 ORX61396.1 - 2.2e-19 69.7 0.0 4.3e-19 68.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain GAS2 PF02187.17 ORX61397.1 - 4.7e-12 45.8 0.0 1.4e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Got1 PF04178.12 ORX61398.1 - 2.9e-18 66.3 13.1 3.4e-18 66.1 13.1 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family PWI PF01480.17 ORX61399.1 - 8.4e-30 102.9 0.1 1.4e-29 102.2 0.1 1.3 1 0 0 1 1 1 1 PWI domain ABC_tran_Xtn PF12848.7 ORX61399.1 - 0.0018 18.3 4.0 0.0043 17.0 4.0 1.6 1 0 0 1 1 1 1 ABC transporter DUF2457 PF10446.9 ORX61399.1 - 0.066 12.3 32.2 0.12 11.5 32.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NDT80_PhoG PF05224.12 ORX61401.1 - 1.4e-36 126.4 0.0 7e-36 124.2 0.0 2.0 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family Mito_carr PF00153.27 ORX61402.1 - 2.5e-71 235.7 3.1 2.6e-23 81.7 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX61402.1 - 0.05 12.7 0.5 7.8 5.6 0.0 3.0 2 1 0 3 3 3 0 Gammaproteobacterial serine protease MtrD PF04207.12 ORX61402.1 - 0.21 11.3 3.8 0.29 10.8 0.1 2.9 3 1 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit D VTC PF09359.10 ORX61403.1 - 6.1e-69 232.5 1.1 9.8e-69 231.8 1.1 1.3 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 ORX61403.1 - 9.6e-17 62.0 15.7 1.6e-09 38.2 0.4 4.2 2 1 1 4 4 4 3 SPX domain DUF202 PF02656.15 ORX61403.1 - 8.8e-13 48.5 1.5 2e-12 47.4 1.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) ACOX PF01756.19 ORX61404.1 - 3e-51 173.5 0.0 5.3e-51 172.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ORX61404.1 - 5.1e-20 71.5 0.0 9.1e-20 70.7 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ORX61404.1 - 3.7e-15 56.6 0.2 8.6e-15 55.4 0.2 1.6 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 ORX61404.1 - 2e-07 31.4 0.8 8.7e-06 26.0 0.8 2.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PHA_gran_rgn PF09650.10 ORX61404.1 - 0.12 12.7 0.4 27 5.1 0.0 2.7 2 0 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) Vps8 PF12816.7 ORX61405.1 - 1.2e-66 224.0 0.0 1e-65 221.0 0.0 2.4 2 0 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 zf-RING_5 PF14634.6 ORX61405.1 - 0.0012 18.7 2.0 0.0038 17.1 2.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain WD40 PF00400.32 ORX61405.1 - 0.021 15.7 0.5 0.021 15.7 0.5 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat zf-RING_11 PF17123.5 ORX61405.1 - 0.025 14.3 0.2 0.16 11.7 0.2 2.5 1 0 0 1 1 1 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX61405.1 - 0.25 11.2 7.2 0.07 13.0 3.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 ORX61405.1 - 0.29 11.2 2.0 0.7 10.0 2.0 1.6 1 0 0 1 1 1 0 Zinc-finger zf-RING_UBOX PF13445.6 ORX61405.1 - 0.65 10.1 7.7 0.037 14.0 1.8 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX61405.1 - 5.1 7.0 5.7 20 5.1 2.7 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF382 PF04037.13 ORX61406.1 - 3e-58 195.5 2.2 3e-58 195.5 2.2 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF382) PSP PF04046.16 ORX61406.1 - 5.2e-19 67.9 6.1 1.1e-18 66.8 6.1 1.6 1 0 0 1 1 1 1 PSP Kinesin PF00225.23 ORX61407.1 - 2.2e-103 345.7 10.0 6e-60 202.9 0.0 4.2 4 1 0 5 5 5 2 Kinesin motor domain Microtub_bd PF16796.5 ORX61407.1 - 1.6e-24 86.5 0.1 2.4e-20 73.0 0.1 3.7 2 0 0 2 2 2 2 Microtubule binding TMF_DNA_bd PF12329.8 ORX61407.1 - 0.004 17.1 7.6 0.004 17.1 7.6 13.5 12 4 5 17 17 17 2 TATA element modulatory factor 1 DNA binding Tup_N PF08581.10 ORX61407.1 - 0.0083 16.4 2.7 0.0083 16.4 2.7 9.8 9 2 2 12 12 12 1 Tup N-terminal Pox_A_type_inc PF04508.12 ORX61407.1 - 0.12 12.3 9.0 0.44 10.5 0.0 5.6 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat RAMP4 PF06624.12 ORX61408.1 - 2.7 8.1 6.3 14 5.8 4.5 2.5 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 Tub PF01167.18 ORX61409.1 - 9.7e-77 258.0 0.0 1.2e-76 257.7 0.0 1.1 1 0 0 1 1 1 1 Tub family Wzt_C PF14524.6 ORX61410.1 - 8.2e-05 22.7 0.0 0.00017 21.6 0.0 1.5 2 0 0 2 2 2 1 Wzt C-terminal domain GPI-anchored PF10342.9 ORX61410.1 - 0.0026 18.5 0.3 0.0045 17.7 0.3 1.5 1 1 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Big_7 PF17957.1 ORX61410.1 - 0.028 15.2 4.7 0.28 12.0 4.7 2.3 1 1 0 1 1 1 0 Bacterial Ig domain BsuPI PF12690.7 ORX61410.1 - 0.097 12.7 0.0 5.8 7.0 0.0 2.1 1 1 1 2 2 2 0 Intracellular proteinase inhibitor ASH PF15780.5 ORX61410.1 - 0.17 12.1 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Glyco_hydro_17 PF00332.18 ORX61411.1 - 7.6e-08 32.3 1.0 7.6e-08 32.3 1.0 2.4 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 F-box-like PF12937.7 ORX61412.1 - 2.5e-05 24.1 0.4 2.5e-05 24.1 0.4 2.6 3 0 0 3 3 3 1 F-box-like RepA1_leader PF08048.12 ORX61412.1 - 0.00083 19.6 2.2 0.0018 18.5 0.3 2.7 2 0 0 2 2 2 1 Tap RepA1 leader peptide Octopine_DH PF02317.17 ORX61413.1 - 0.072 13.2 0.3 0.17 12.0 0.0 1.7 2 0 0 2 2 2 0 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain NST1 PF13945.6 ORX61415.1 - 3.4e-46 157.8 23.9 2.5e-45 155.0 22.0 2.3 1 1 1 2 2 2 2 Salt tolerance down-regulator TPT PF03151.16 ORX61416.1 - 5e-20 72.0 10.3 5.7e-20 71.8 10.3 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ORX61416.1 - 8.8e-12 45.4 20.4 2.2e-08 34.4 10.9 2.1 2 0 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 ORX61416.1 - 0.00043 19.6 12.4 0.00053 19.3 12.4 1.1 1 0 0 1 1 1 1 UAA transporter family DUF2070 PF09843.9 ORX61416.1 - 0.035 12.4 10.1 0.043 12.1 10.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SLATT_1 PF18181.1 ORX61416.1 - 0.083 12.8 2.1 0.18 11.7 0.1 2.2 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 DUF1129 PF06570.11 ORX61416.1 - 0.11 12.0 8.0 0.043 13.3 2.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) OST3_OST6 PF04756.13 ORX61416.1 - 2.6 7.3 7.4 1.4 8.2 5.3 1.7 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family TPT PF03151.16 ORX61417.1 - 0.0024 17.3 0.1 0.0031 16.9 0.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family LSM PF01423.22 ORX61418.1 - 3.2e-18 65.2 0.3 4.1e-18 64.8 0.3 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX61418.1 - 0.12 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Hfq protein WD40 PF00400.32 ORX61420.1 - 1.7e-22 79.2 7.6 1.4e-06 28.9 0.6 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61420.1 - 1.8e-07 31.3 0.0 1.1 9.6 0.0 5.4 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX61420.1 - 0.0013 17.5 1.4 0.18 10.4 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX61420.1 - 0.014 14.7 0.0 1.8 7.8 0.0 3.2 3 1 1 4 4 4 0 WD40-like domain tRNA-synt_2d PF01409.20 ORX61421.1 - 9.6e-90 300.3 0.1 1.2e-89 300.0 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 ORX61421.1 - 3.9e-21 75.1 1.7 6e-21 74.5 0.2 2.2 2 0 0 2 2 2 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 ORX61421.1 - 8.4e-08 31.9 0.0 9.7e-05 21.9 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ORX61421.1 - 0.00018 20.7 2.3 0.0014 17.8 0.1 2.9 2 2 1 4 4 4 1 tRNA synthetases class II (D, K and N) PheRS_DBD2 PF18554.1 ORX61421.1 - 0.00045 20.2 3.9 0.0006 19.8 2.5 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 2 S10_plectin PF03501.15 ORX61421.1 - 0.0035 17.4 0.0 0.0073 16.4 0.0 1.4 1 0 0 1 1 1 1 Plectin/S10 domain DUF505 PF04458.12 ORX61421.1 - 0.041 12.3 1.6 0.22 9.9 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF505) CK_II_beta PF01214.18 ORX61422.1 - 7.7e-82 273.5 0.0 9.4e-82 273.2 0.0 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit SYCP2_SLD PF18584.1 ORX61422.1 - 0.027 14.7 0.2 0.045 14.0 0.2 1.3 1 0 0 1 1 1 0 Synaptonemal complex 2 Spt16M-like domain CxC5 PF18718.1 ORX61422.1 - 0.039 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases AMPK1_CBM PF16561.5 ORX61424.1 - 4e-34 116.7 0.4 6.8e-34 116.0 0.4 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 ORX61424.1 - 1.1e-25 89.7 2.7 1.1e-25 89.7 2.7 2.5 2 1 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM_48 PF02922.18 ORX61424.1 - 0.0034 17.7 0.0 0.0077 16.6 0.0 1.5 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) CBM53 PF16760.5 ORX61424.1 - 0.0096 16.5 1.3 0.034 14.7 0.1 2.2 2 0 0 2 2 2 1 Starch/carbohydrate-binding module (family 53) O-FucT PF10250.9 ORX61425.1 - 1.1e-05 25.4 0.2 1.7e-05 24.7 0.2 1.3 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Ribul_P_3_epim PF00834.19 ORX61426.1 - 4.7e-74 248.1 0.3 5.6e-74 247.8 0.3 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 ORX61426.1 - 0.036 13.7 0.1 0.052 13.1 0.1 1.4 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family QRPTase_C PF01729.19 ORX61426.1 - 0.048 13.4 0.1 0.12 12.1 0.0 1.8 2 1 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain Brix PF04427.18 ORX61427.1 - 8.3e-39 133.7 0.1 1.2e-38 133.2 0.1 1.2 1 0 0 1 1 1 1 Brix domain OrfB_Zn_ribbon PF07282.11 ORX61430.1 - 1.8e-08 34.2 0.7 1.8e-08 34.2 0.7 2.4 2 0 0 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX61430.1 - 0.076 13.1 7.9 0.082 13.0 1.5 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF4407 PF14362.6 ORX61430.1 - 1.5 8.1 7.3 1.7 7.9 2.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) OmpH PF03938.14 ORX61430.1 - 7.2 7.0 6.9 2.5 8.4 2.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Sugar_tr PF00083.24 ORX61431.1 - 3.3e-99 332.8 19.2 5.8e-99 332.0 19.2 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ORX61431.1 - 4e-27 95.1 29.7 1.8e-23 83.1 20.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 ORX61431.1 - 0.00027 19.5 4.4 0.00045 18.8 4.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DegS PF05384.11 ORX61431.1 - 0.13 11.8 0.1 0.26 10.8 0.0 1.5 2 0 0 2 2 2 0 Sensor protein DegS RhoGAP PF00620.27 ORX61432.1 - 1.6e-38 131.9 0.0 2.4e-38 131.3 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DUF1708 PF08101.11 ORX61432.1 - 0.025 13.8 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Adeno_E3_15_3 PF03307.14 ORX61432.1 - 0.03 14.3 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region DHHC PF01529.20 ORX61435.1 - 7.3e-39 132.9 5.5 1.2e-38 132.2 5.5 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase Scramblase PF03803.15 ORX61437.1 - 3.4e-58 196.5 0.0 4.3e-58 196.2 0.0 1.1 1 0 0 1 1 1 1 Scramblase LOR PF04525.12 ORX61437.1 - 0.0023 17.6 0.1 0.016 14.9 0.1 2.2 2 1 1 3 3 3 1 LURP-one-related TruB_C PF09142.11 ORX61437.1 - 0.033 14.0 0.0 0.097 12.5 0.0 1.8 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal GARP PF16731.5 ORX61438.1 - 0.0001 22.1 11.8 0.0001 22.1 11.8 1.1 1 0 0 1 1 1 1 Glutamic acid/alanine-rich protein of Trypanosoma Alanine_zipper PF11839.8 ORX61438.1 - 0.034 14.5 20.4 0.049 14.0 20.2 1.4 1 1 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein Mago_nashi PF02792.14 ORX61439.1 - 9.2e-71 236.5 0.5 1e-70 236.4 0.5 1.0 1 0 0 1 1 1 1 Mago nashi protein Indigoidine_A PF04227.12 ORX61440.1 - 8.2e-131 435.7 3.4 9.4e-131 435.5 3.4 1.0 1 0 0 1 1 1 1 Indigoidine synthase A like protein TPP_enzyme_N PF02776.18 ORX61440.1 - 0.033 13.8 1.1 0.055 13.1 0.2 1.9 2 1 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Adeno_PIX PF03955.14 ORX61440.1 - 0.14 12.3 1.5 9.9 6.4 0.3 2.4 2 0 0 2 2 2 0 Adenovirus hexon-associated protein (IX) PX PF00787.24 ORX61441.1 - 6.7e-26 90.5 2.3 5.2e-25 87.6 0.2 2.4 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 ORX61441.1 - 9.3e-11 41.7 11.4 1.1e-07 31.6 3.0 2.1 1 1 0 2 2 2 2 Vps5 C terminal like SHE3 PF17078.5 ORX61441.1 - 0.0019 18.0 3.0 0.0019 18.0 3.0 2.3 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 DUF16 PF01519.16 ORX61441.1 - 0.0041 17.6 3.6 0.083 13.4 0.0 2.8 2 1 0 2 2 2 1 Protein of unknown function DUF16 Snapin_Pallidin PF14712.6 ORX61441.1 - 0.0057 17.0 5.3 0.15 12.5 0.1 2.8 3 0 0 3 3 2 1 Snapin/Pallidin BAR_3 PF16746.5 ORX61441.1 - 0.01 15.6 6.8 0.23 11.2 6.8 2.7 1 1 0 1 1 1 0 BAR domain of APPL family Prefoldin_3 PF13758.6 ORX61441.1 - 0.056 13.5 1.1 0.28 11.3 0.1 2.6 2 0 0 2 2 2 0 Prefoldin subunit Laminin_II PF06009.12 ORX61441.1 - 0.13 12.3 2.5 0.5 10.4 0.0 2.6 2 1 1 3 3 3 0 Laminin Domain II DUF1664 PF07889.12 ORX61441.1 - 0.14 12.2 3.2 11 6.1 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ORX61441.1 - 0.45 10.8 2.7 4.7 7.6 0.2 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) MCC-bdg_PDZ PF10506.9 ORX61441.1 - 0.57 10.2 3.7 21 5.2 0.4 2.8 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome SlyX PF04102.12 ORX61441.1 - 0.72 10.5 3.3 22 5.8 0.1 3.6 3 1 1 4 4 4 0 SlyX ING PF12998.7 ORX61441.1 - 1.1 9.9 6.9 1.2 9.8 0.2 2.8 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding BLOC1_2 PF10046.9 ORX61441.1 - 1.6 9.1 6.9 4.8 7.5 0.2 3.4 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Trimer_CC PF08954.11 ORX61441.1 - 2.1 8.0 6.3 0.42 10.2 0.1 2.9 3 0 0 3 3 3 0 Trimerisation motif Fib_alpha PF08702.10 ORX61441.1 - 5 7.3 8.6 13 5.9 0.1 3.1 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family ELFV_dehydrog_N PF02812.18 ORX61442.1 - 3.1e-58 195.3 0.0 5.7e-58 194.4 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ORX61442.1 - 6.3e-56 189.8 0.6 7.1e-53 179.8 0.0 2.2 1 1 1 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ORX61442.1 - 0.0024 15.5 0.1 0.008 13.7 0.0 1.8 2 1 0 2 2 2 1 Bacterial NAD-glutamate dehydrogenase DUF1611_N PF17396.2 ORX61442.1 - 0.066 13.5 0.0 0.84 9.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1611_N) Rossmann-like domain 2-Hacid_dh_C PF02826.19 ORX61442.1 - 0.075 12.4 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FdsD PF11390.8 ORX61442.1 - 0.093 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD NAD_binding_7 PF13241.6 ORX61442.1 - 0.14 12.6 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Mito_carr PF00153.27 ORX61443.1 - 1.4e-61 204.5 2.4 7.8e-20 70.6 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein zf-C2H2_2 PF12756.7 ORX61444.1 - 0.00091 19.5 0.6 0.0061 16.9 0.5 2.2 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 ORX61444.1 - 0.0055 17.4 1.3 9.2 7.4 0.0 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ORX61444.1 - 0.016 15.9 0.0 7.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2 PF00096.26 ORX61444.1 - 0.036 14.5 2.0 3.1 8.4 0.5 3.2 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 ORX61444.1 - 0.068 13.0 0.6 4 7.3 0.0 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) DUF4451 PF14616.6 ORX61444.1 - 0.069 13.4 0.5 0.13 12.4 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4451) DUF3925 PF13063.6 ORX61444.1 - 0.17 12.1 0.1 0.35 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3925) UPF0547 PF10571.9 ORX61444.1 - 2.1 8.5 4.1 7.5 6.7 0.1 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 ATP-synt_ab PF00006.25 ORX61445.1 - 1.2e-109 365.0 0.0 1.8e-109 364.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ORX61445.1 - 3.2e-42 143.2 0.0 5.6e-42 142.4 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ORX61445.1 - 2.1e-13 50.6 1.9 2.1e-13 50.6 1.9 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain SNF2_N PF00176.23 ORX61446.1 - 1e-59 202.1 0.0 1.8e-59 201.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX61446.1 - 3.7e-18 65.9 0.0 8.6e-18 64.7 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ORX61446.1 - 1.4e-13 50.5 0.3 4e-10 39.4 0.0 2.9 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ORX61446.1 - 5.9e-08 32.9 0.0 1.6e-07 31.5 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CHDCT2 PF08074.11 ORX61446.1 - 8.9e-06 26.0 1.8 0.057 13.6 0.3 3.6 3 0 0 3 3 3 2 CHDCT2 (NUC038) domain HDA2-3 PF11496.8 ORX61446.1 - 1.5e-05 24.3 0.0 5.6e-05 22.4 0.0 1.9 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 GSH-S_ATP PF02955.16 ORX61446.1 - 0.048 13.0 0.0 0.097 12.1 0.0 1.4 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain Myb_DNA-binding PF00249.31 ORX61446.1 - 0.059 13.6 0.2 0.67 10.2 0.0 2.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain ToxN_toxin PF13958.6 ORX61446.1 - 0.11 12.7 1.4 0.49 10.6 0.3 2.3 2 0 0 2 2 2 0 Toxin ToxN, type III toxin-antitoxin system GPI-anchored PF10342.9 ORX61447.1 - 0.0088 16.8 0.2 0.034 14.9 0.2 1.9 1 1 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family DUF4625 PF15418.6 ORX61447.1 - 0.079 13.2 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4625) p450 PF00067.22 ORX61448.1 - 1e-66 225.6 0.7 4.3e-66 223.5 0.7 1.7 1 1 0 1 1 1 1 Cytochrome P450 Peptidase_M20 PF01546.28 ORX61449.1 - 5.1e-29 101.5 0.0 7.5e-29 100.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 ORX61449.1 - 4e-25 87.6 22.4 5.7e-08 33.3 0.2 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat M20_dimer PF07687.14 ORX61449.1 - 2.8e-09 36.9 0.0 6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 ORX61449.1 - 5.6e-07 29.8 0.1 0.19 12.1 0.0 4.8 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX61449.1 - 5.1e-06 25.4 0.6 0.00072 18.3 0.1 2.5 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX61449.1 - 5.3e-05 22.7 0.8 1.2 8.4 0.1 3.7 3 1 0 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ORX61449.1 - 0.046 12.4 1.5 7.2 5.2 0.0 3.2 2 2 1 3 3 3 0 Nup133 N terminal like GTP1_OBG PF01018.22 ORX61450.1 - 1.9e-45 154.3 4.2 8.6e-30 103.4 3.1 2.2 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 ORX61450.1 - 1.5e-21 76.6 0.0 2.5e-21 75.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX61450.1 - 8.8e-07 28.6 0.0 5.7e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ORX61450.1 - 7.8e-05 22.2 0.0 0.00013 21.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX61450.1 - 0.00055 19.4 0.0 0.00089 18.7 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1_C PF08438.10 ORX61450.1 - 0.0034 18.0 0.1 0.0097 16.5 0.1 1.8 1 0 0 1 1 1 1 GTPase of unknown function C-terminal ABC_tran PF00005.27 ORX61450.1 - 0.052 14.0 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 ORX61450.1 - 0.15 12.0 0.3 7.7 6.4 0.0 2.6 3 0 0 3 3 3 0 RsgA GTPase Dynamin_N PF00350.23 ORX61450.1 - 0.17 11.9 0.1 7.8 6.5 0.0 2.3 1 1 1 2 2 2 0 Dynamin family DUF3989 PF13150.6 ORX61452.1 - 0.0062 16.2 0.2 0.0081 15.9 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3989) MIG-14_Wnt-bd PF06664.12 ORX61452.1 - 0.0068 15.7 0.1 0.0079 15.5 0.1 1.2 1 0 0 1 1 1 1 Wnt-binding factor required for Wnt secretion Herpes_glycop PF01528.16 ORX61452.1 - 0.0091 14.9 0.0 0.01 14.7 0.0 1.1 1 0 0 1 1 1 1 Herpesvirus glycoprotein M DUF4131 PF13567.6 ORX61452.1 - 0.011 15.4 0.1 0.014 15.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) PalH PF08733.10 ORX61452.1 - 0.033 13.2 0.1 0.033 13.2 0.1 1.1 1 0 0 1 1 1 0 PalH/RIM21 DUF4381 PF14316.6 ORX61452.1 - 0.04 14.1 0.0 0.04 14.1 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Sensor PF13796.6 ORX61452.1 - 0.042 13.9 0.1 0.051 13.6 0.1 1.1 1 0 0 1 1 1 0 Putative sensor ATG27 PF09451.10 ORX61452.1 - 0.063 13.1 0.2 0.099 12.5 0.1 1.4 1 1 0 1 1 1 0 Autophagy-related protein 27 TMEM223 PF14640.6 ORX61452.1 - 0.12 12.6 0.1 0.14 12.4 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 223 TMEM156 PF15106.6 ORX61452.1 - 0.16 11.4 0.5 0.21 11.0 0.5 1.1 1 0 0 1 1 1 0 TMEM156 protein family p450 PF00067.22 ORX61453.1 - 1.3e-77 261.6 0.0 1.5e-77 261.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Phage_integrase PF00589.22 ORX61453.1 - 0.14 11.9 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Phage integrase family p450 PF00067.22 ORX61455.1 - 2.8e-78 263.7 0.2 3.5e-78 263.4 0.2 1.0 1 0 0 1 1 1 1 Cytochrome P450 HLH PF00010.26 ORX61456.1 - 0.015 15.3 0.4 0.018 15.0 0.4 1.2 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Myb_DNA-binding PF00249.31 ORX61457.1 - 7.3e-16 58.1 1.2 8.2e-15 54.7 0.8 2.7 3 0 0 3 3 3 1 Myb-like DNA-binding domain zf-C2H2 PF00096.26 ORX61457.1 - 1.1e-15 57.1 16.9 2.8e-05 24.3 2.6 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX61457.1 - 1.7e-12 47.2 12.0 3.4e-07 30.4 1.4 3.7 3 0 0 3 3 3 2 Zinc-finger double domain Myb_DNA-bind_6 PF13921.6 ORX61457.1 - 1.5e-11 44.3 0.3 8.5e-11 41.9 0.2 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain zf-C2H2_4 PF13894.6 ORX61457.1 - 1.5e-10 40.9 12.7 0.00063 20.4 1.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX61457.1 - 3.7e-07 30.0 12.2 0.012 15.6 1.0 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2HE PF16278.5 ORX61457.1 - 4.6e-06 27.0 7.7 0.0013 19.1 1.2 3.2 1 1 2 3 3 3 2 C2HE / C2H2 / C2HC zinc-binding finger SLIDE PF09111.10 ORX61457.1 - 0.00014 21.9 0.5 0.00043 20.3 0.0 2.1 2 0 0 2 2 2 1 SLIDE CHDCT2 PF08074.11 ORX61457.1 - 0.0048 17.1 0.0 0.0048 17.1 0.0 3.1 3 0 0 3 3 3 1 CHDCT2 (NUC038) domain DZR PF12773.7 ORX61457.1 - 0.11 12.6 0.9 0.23 11.5 0.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ORX61457.1 - 0.14 12.3 2.5 3.8 7.7 0.1 2.8 2 1 1 3 3 3 0 Zinc ribbon domain zf-C2H2_jaz PF12171.8 ORX61457.1 - 0.17 12.2 7.2 1.4 9.3 0.2 3.0 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX61457.1 - 0.37 11.2 10.5 2.9 8.4 0.8 3.3 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-LYAR PF08790.11 ORX61457.1 - 0.4 10.6 4.8 8.9 6.3 0.2 3.3 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Rap1_C PF11626.8 ORX61457.1 - 0.43 10.7 1.8 0.76 9.9 0.3 2.2 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain zf-BED PF02892.15 ORX61457.1 - 0.69 10.0 6.3 1.5 9.0 1.2 2.9 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_8 PF15909.5 ORX61457.1 - 1.1 9.6 8.0 0.21 11.9 1.6 2.8 2 1 1 3 3 3 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ORX61457.1 - 3.4 7.5 6.1 3.1 7.6 0.1 2.7 3 0 0 3 3 2 0 zinc-finger C2H2-type Cullin PF00888.22 ORX61458.1 - 3e-204 680.2 15.1 3.8e-204 679.8 15.1 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ORX61458.1 - 7.9e-26 89.9 1.5 7.9e-26 89.9 1.5 2.1 2 0 0 2 2 2 1 Cullin protein neddylation domain HTH_IclR PF09339.10 ORX61458.1 - 0.017 14.9 0.2 0.045 13.6 0.2 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain MitMem_reg PF13012.6 ORX61458.1 - 0.16 12.4 2.6 12 6.4 0.5 3.7 3 0 0 3 3 3 0 Maintenance of mitochondrial structure and function UPF0203 PF05254.12 ORX61459.1 - 8.5e-06 25.9 3.4 1.6e-05 25.1 3.4 1.5 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0203) CX9C PF16860.5 ORX61459.1 - 3.1e-05 23.9 2.3 0.021 14.8 0.3 2.2 1 1 1 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 ORX61459.1 - 0.0024 18.0 2.5 0.015 15.4 1.3 2.0 2 0 0 2 2 2 1 CHCH domain UCR_hinge PF02320.16 ORX61459.1 - 0.0029 17.8 1.0 0.0031 17.7 1.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein Cmc1 PF08583.10 ORX61459.1 - 0.0034 17.4 3.4 0.15 12.1 1.6 1.8 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 ORX61459.1 - 0.021 15.2 1.9 0.028 14.8 1.9 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) DUF1104 PF06518.11 ORX61459.1 - 0.023 15.1 0.1 0.023 15.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) NDUF_B7 PF05676.13 ORX61459.1 - 0.043 13.5 1.7 0.76 9.5 0.3 1.9 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) RRM_1 PF00076.22 ORX61460.1 - 1.5e-36 124.0 3.9 1.9e-18 66.1 0.3 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4944 PF16302.5 ORX61460.1 - 6.5e-05 23.0 0.0 0.26 11.4 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4944) RRM_7 PF16367.5 ORX61460.1 - 0.00029 20.9 0.1 0.3 11.2 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif RRM_occluded PF16842.5 ORX61460.1 - 0.018 14.9 0.1 6.4 6.7 0.0 2.5 2 1 0 2 2 2 0 Occluded RNA-recognition motif RRM_Rrp7 PF17799.1 ORX61460.1 - 0.03 14.1 0.0 0.89 9.3 0.0 2.3 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain DbpA PF03880.15 ORX61460.1 - 0.03 14.3 0.1 14 5.7 0.0 2.9 3 0 0 3 3 3 0 DbpA RNA binding domain Haemagg_act PF05860.13 ORX61460.1 - 0.049 13.5 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 haemagglutination activity domain SecD-TM1 PF13721.6 ORX61460.1 - 0.093 13.2 0.2 0.57 10.7 0.0 2.2 2 0 0 2 2 2 0 SecD export protein N-terminal TM region DUF4953 PF16313.5 ORX61460.1 - 0.13 11.4 6.5 0.19 10.9 3.0 2.1 1 1 1 2 2 2 0 Met-zincin PHM7_cyt PF14703.6 ORX61460.1 - 0.14 12.4 9.1 0.3 11.3 0.0 2.8 1 1 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 ORX61460.1 - 0.17 11.5 1.6 2.5 7.8 0.1 3.1 3 0 0 3 3 3 0 Ribonuclease B OB domain DUF3343 PF11823.8 ORX61460.1 - 0.18 11.3 0.0 3.5 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) DUF1168 PF06658.12 ORX61460.1 - 0.98 9.2 22.0 0.99 9.2 20.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1168) IF4E PF01652.18 ORX61462.1 - 3.6e-25 88.6 0.0 5.7e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2024 PF09630.10 ORX61462.1 - 0.2 11.6 0.0 0.44 10.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) Transposase_31 PF04754.12 ORX61462.1 - 0.24 11.0 0.1 0.38 10.3 0.1 1.2 1 0 0 1 1 1 0 Putative transposase, YhgA-like Clathrin PF00637.20 ORX61465.1 - 4.8e-184 603.6 38.1 7.1e-32 110.3 3.3 8.1 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 ORX61465.1 - 3.6e-30 103.7 0.1 3.6e-30 103.7 0.1 2.9 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.20 ORX61465.1 - 1.9e-28 97.4 2.3 8.5e-09 35.3 0.1 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin-link PF09268.10 ORX61465.1 - 4.5e-09 35.5 0.2 1.5e-08 33.9 0.2 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 ORX61465.1 - 7.4e-07 28.6 5.7 0.00092 18.4 0.2 4.3 4 0 0 4 4 4 2 Coatomer WD associated region TPR_1 PF00515.28 ORX61465.1 - 0.00019 21.1 3.5 0.095 12.6 0.0 4.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX61465.1 - 0.0012 19.3 0.8 2.8 8.5 0.1 5.8 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX61465.1 - 0.0023 18.0 1.4 21 5.7 0.1 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61465.1 - 0.013 15.6 7.9 4.7 7.6 0.0 5.2 4 0 0 4 4 3 0 Tetratricopeptide repeat MHC2-interact PF09307.10 ORX61465.1 - 0.12 12.4 0.3 0.26 11.3 0.3 1.5 1 0 0 1 1 1 0 CLIP, MHC2 interacting TPR_17 PF13431.6 ORX61465.1 - 0.3 11.6 3.5 73 4.1 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX61465.1 - 0.96 9.7 4.0 25 5.2 0.1 4.1 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2423 PF10338.9 ORX61466.1 - 2.7e-14 53.1 5.0 2.7e-14 53.1 5.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) Sacchrp_dh_NADP PF03435.18 ORX61466.1 - 0.055 13.7 0.1 0.11 12.7 0.0 1.4 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain AP_endonuc_2_N PF07582.12 ORX61466.1 - 0.097 12.4 0.2 0.16 11.7 0.2 1.3 1 0 0 1 1 1 0 AP endonuclease family 2 C terminus Voldacs PF03517.13 ORX61467.1 - 1.1e-20 74.2 2.7 4.6e-20 72.2 2.7 1.8 1 1 0 1 1 1 1 Regulator of volume decrease after cellular swelling GRAM PF02893.20 ORX61467.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 GRAM domain RmlD_sub_bind PF04321.17 ORX61468.1 - 5.3e-57 193.1 0.0 6.4e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 ORX61468.1 - 3.7e-18 65.9 0.0 5e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX61468.1 - 8.5e-08 32.0 0.0 1.2e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ORX61468.1 - 3.3e-05 23.2 0.0 0.00011 21.5 0.0 1.8 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ORX61468.1 - 0.026 13.7 0.0 0.11 11.6 0.0 1.8 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein TPR_MLP1_2 PF07926.12 ORX61469.1 - 1.8e-08 34.5 16.3 1.8e-08 34.5 16.3 11.2 4 2 7 11 11 11 3 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ORX61469.1 - 0.0027 16.7 16.0 0.0027 16.7 16.0 8.9 2 2 4 8 8 8 5 Spc7 kinetochore protein ING PF12998.7 ORX61469.1 - 0.024 15.2 0.7 0.024 15.2 0.7 10.0 7 3 4 11 11 11 0 Inhibitor of growth proteins N-terminal histone-binding VGPC1_C PF16799.5 ORX61469.1 - 0.025 14.5 5.5 0.036 14.0 0.5 3.9 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 ABC_tran_CTD PF16326.5 ORX61469.1 - 0.029 14.6 0.4 0.029 14.6 0.4 14.8 11 4 2 14 14 14 0 ABC transporter C-terminal domain YojJ PF10372.9 ORX61469.1 - 3.5 7.8 20.4 0.71 10.0 1.6 6.2 6 0 0 6 6 6 0 Bacterial membrane-spanning protein N-terminus Atg14 PF10186.9 ORX61470.1 - 0.0049 16.0 22.0 0.0049 16.0 22.0 2.1 1 1 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-H PF05837.12 ORX61470.1 - 0.027 14.9 10.2 0.027 14.9 10.2 3.4 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 ORX61470.1 - 0.26 11.3 29.9 0.18 11.8 2.1 3.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 ORX61470.1 - 0.69 8.5 47.9 1.5 7.3 24.8 2.4 1 1 2 3 3 3 0 AAA domain Fez1 PF06818.15 ORX61470.1 - 0.7 10.3 48.7 0.049 14.1 14.8 2.5 1 1 1 2 2 2 0 Fez1 IFT57 PF10498.9 ORX61470.1 - 1.2 8.1 39.9 38 3.1 39.9 3.1 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 ERM PF00769.19 ORX61470.1 - 1.8 8.4 66.7 0.019 14.8 29.7 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Zn_Tnp_IS1595 PF12760.7 ORX61471.1 - 0.0019 18.1 3.8 0.0038 17.2 3.8 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain FdhE PF04216.12 ORX61471.1 - 0.23 11.3 1.2 2.6 7.9 0.2 2.2 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation TFIIS_C PF01096.18 ORX61471.1 - 0.94 9.4 5.1 8 6.4 5.1 2.1 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) DDHD PF02862.17 ORX61472.1 - 2.7e-25 89.8 4.5 1.2e-14 55.0 2.0 2.2 2 0 0 2 2 2 2 DDHD domain SelP_N PF04592.14 ORX61472.1 - 8.5 5.7 11.3 19 4.6 11.1 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Zn_clus PF00172.18 ORX61473.1 - 4e-09 36.5 10.0 6.6e-09 35.7 10.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PBP PF01161.20 ORX61474.1 - 3.3e-21 76.0 0.1 4e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein SUI1 PF01253.22 ORX61475.1 - 1e-24 86.8 0.4 1.3e-24 86.5 0.4 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 GPI-anchored PF10342.9 ORX61476.1 - 0.0013 19.4 0.1 0.002 18.8 0.1 1.3 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family CS PF04969.16 ORX61478.1 - 1.3e-19 71.0 0.9 2.5e-19 70.1 0.3 1.8 2 0 0 2 2 2 1 CS domain Pkinase PF00069.25 ORX61479.1 - 1.3e-34 119.8 0.0 3.4e-34 118.4 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Kelch_5 PF13854.6 ORX61479.1 - 1e-16 60.5 15.6 7.7e-07 29.0 0.2 5.5 5 0 0 5 5 5 4 Kelch motif Kelch_1 PF01344.25 ORX61479.1 - 2.4e-15 55.8 18.9 0.00041 19.9 0.5 5.6 5 0 0 5 5 5 5 Kelch motif Kelch_2 PF07646.15 ORX61479.1 - 2.8e-15 55.6 17.9 0.00025 20.9 0.7 6.4 6 0 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 ORX61479.1 - 1.1e-13 51.0 33.9 7.2e-06 26.2 0.1 6.9 7 0 0 7 7 7 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX61479.1 - 9.5e-12 44.8 21.4 0.00017 21.7 0.6 5.7 4 1 1 5 5 5 4 Kelch motif Kelch_4 PF13418.6 ORX61479.1 - 1.6e-08 34.5 19.2 0.00039 20.4 0.2 5.7 4 1 1 5 5 5 3 Galactose oxidase, central domain Kinase-like PF14531.6 ORX61479.1 - 1.2e-07 31.4 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like SKG6 PF08693.10 ORX61479.1 - 5.1e-06 25.8 1.8 1.3e-05 24.5 1.8 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Pkinase_Tyr PF07714.17 ORX61479.1 - 2.9e-05 23.5 0.0 8.5e-05 22.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase EphA2_TM PF14575.6 ORX61479.1 - 0.015 16.1 0.0 0.036 14.9 0.0 1.6 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Choline_kinase PF01633.20 ORX61479.1 - 0.07 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Adeno_E3_CR2 PF02439.15 ORX61479.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 NICE-1 PF15845.5 ORX61479.1 - 0.19 12.6 0.0 0.19 12.6 0.0 3.8 4 0 0 4 4 1 0 Cysteine-rich C-terminal 1 family DNA_pol3_tau_4 PF12168.8 ORX61479.1 - 0.59 10.7 3.7 30 5.2 1.2 3.2 2 1 0 2 2 2 0 DNA polymerase III subunits tau domain IV DnaB-binding Mitoc_mL59 PF18126.1 ORX61480.1 - 2e-10 41.0 8.4 1.2e-09 38.6 8.4 1.9 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 CR6_interact PF10147.9 ORX61480.1 - 0.0021 17.8 6.1 0.0034 17.1 6.1 1.3 1 0 0 1 1 1 1 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 AbiGi PF10899.8 ORX61480.1 - 0.0023 17.8 0.1 0.003 17.4 0.1 1.1 1 0 0 1 1 1 1 Putative abortive phage resistance protein AbiGi, antitoxin U1snRNP70_N PF12220.8 ORX61480.1 - 0.0097 16.5 1.9 0.013 16.2 1.3 1.5 1 1 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RNA_lig_T4_1 PF09511.10 ORX61482.1 - 5.3e-61 206.3 0.0 7.6e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 RNA ligase RNA_ligase PF09414.10 ORX61482.1 - 8.7e-06 26.1 0.0 1.4e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 RNA ligase Acyl_transf_2 PF02273.15 ORX61482.1 - 0.017 14.3 0.0 0.037 13.3 0.0 1.5 1 0 0 1 1 1 0 Acyl transferase Zn_clus PF00172.18 ORX61483.1 - 1.2e-15 57.3 24.8 6.6e-08 32.5 11.3 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1336 PF07059.12 ORX61483.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1336) Pkinase PF00069.25 ORX61485.1 - 1.3e-55 188.7 0.0 1.6e-55 188.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61485.1 - 4.6e-21 75.3 0.0 8.6e-21 74.4 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX61485.1 - 0.00023 21.2 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX61485.1 - 0.027 13.8 0.0 0.047 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX61485.1 - 0.032 13.8 0.0 0.067 12.8 0.0 1.5 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 ORX61485.1 - 0.038 13.6 0.1 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase Metallophos PF00149.28 ORX61487.1 - 1.1e-34 120.8 0.1 1.8e-34 120.1 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DUF5378 PF17349.2 ORX61487.1 - 0.084 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) Acyltransferase PF01553.21 ORX61488.1 - 2.7e-08 33.5 0.0 1.3e-07 31.3 0.0 1.9 1 1 0 1 1 1 1 Acyltransferase Mito_carr PF00153.27 ORX61490.1 - 1.8e-35 120.7 0.5 2.4e-20 72.3 0.0 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein Voltage_CLC PF00654.20 ORX61491.1 - 2.4e-87 293.5 28.8 2.4e-87 293.5 28.8 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 ORX61491.1 - 5e-12 46.1 0.4 4.5e-07 30.2 0.1 2.6 2 0 0 2 2 2 2 CBS domain GTP_EFTU_D4 PF14578.6 ORX61491.1 - 0.18 11.7 0.1 6.9 6.6 0.0 2.9 3 0 0 3 3 3 0 Elongation factor Tu domain 4 TMEM154 PF15102.6 ORX61492.1 - 0.00079 19.3 0.3 0.0054 16.6 0.0 1.9 1 1 1 2 2 2 1 TMEM154 protein family EphA2_TM PF14575.6 ORX61492.1 - 0.0017 19.2 0.0 0.003 18.4 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 ORX61492.1 - 0.01 15.7 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 Herpes_glycop PF01528.16 ORX61492.1 - 0.011 14.6 0.1 0.014 14.3 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus glycoprotein M Rax2 PF12768.7 ORX61492.1 - 0.013 14.9 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF5129 PF17173.4 ORX61492.1 - 0.016 14.3 0.2 0.021 14.0 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) Cytochrom_C_asm PF01578.20 ORX61492.1 - 0.031 14.1 0.0 0.043 13.6 0.0 1.5 1 1 0 1 1 1 0 Cytochrome C assembly protein LapA_dom PF06305.11 ORX61492.1 - 0.035 13.9 0.1 0.066 13.0 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain RD3 PF14473.6 ORX61492.1 - 0.044 13.6 0.3 0.064 13.1 0.3 1.2 1 0 0 1 1 1 0 RD3 protein CcmD PF04995.14 ORX61492.1 - 0.075 13.1 0.2 0.14 12.3 0.2 1.4 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) TauD PF02668.16 ORX61493.1 - 2.3e-47 162.0 3.0 3.1e-47 161.6 3.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ORX61493.1 - 3.3e-09 37.2 0.7 2.6e-08 34.4 0.1 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF971) CsiD PF08943.10 ORX61493.1 - 0.00039 19.6 0.0 0.00052 19.2 0.0 1.3 1 0 0 1 1 1 1 CsiD RicinB_lectin_2 PF14200.6 ORX61494.1 - 0.00013 22.6 0.7 0.0037 18.0 0.1 2.2 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like HMG_box_5 PF14887.6 ORX61494.1 - 0.17 11.9 1.6 0.16 11.9 0.5 1.6 2 0 0 2 2 2 0 HMG (high mobility group) box 5 Homeobox_KN PF05920.11 ORX61495.1 - 2.9e-19 68.7 0.9 2.9e-19 68.7 0.9 1.9 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 ORX61495.1 - 4.1e-08 33.0 0.2 7.3e-08 32.1 0.2 1.4 1 0 0 1 1 1 1 Homeodomain MFS_1 PF07690.16 ORX61497.1 - 4.8e-33 114.6 37.9 9e-32 110.4 39.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily OAD_gamma PF04277.13 ORX61497.1 - 0.094 13.3 0.1 0.37 11.4 0.1 2.0 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FA_hydroxylase PF04116.13 ORX61498.1 - 2.5e-25 89.4 21.6 2.5e-25 89.4 21.6 2.4 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily TcpE PF12648.7 ORX61498.1 - 2.6 8.6 7.5 0.38 11.3 0.3 2.8 3 0 0 3 3 3 0 TcpE family zf-C2H2_6 PF13912.6 ORX61499.1 - 0.0018 18.2 0.7 0.0037 17.2 0.7 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ORX61499.1 - 0.0022 18.7 1.9 0.0038 17.9 1.9 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 ORX61499.1 - 0.015 15.7 1.3 0.022 15.1 1.3 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 ORX61499.1 - 0.021 14.7 0.3 0.047 13.5 0.1 1.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf-C2H2_jaz PF12171.8 ORX61499.1 - 0.026 14.8 0.7 0.042 14.2 0.7 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ORX61499.1 - 0.053 13.3 0.9 0.095 12.5 0.9 1.3 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 ORX61499.1 - 0.054 14.0 4.3 0.093 13.2 4.3 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type PSCyt3 PF07627.11 ORX61499.1 - 0.092 13.0 0.0 0.1 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) DUF4396 PF14342.6 ORX61500.1 - 8.6e-42 142.8 6.0 1.2e-41 142.4 6.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) DUF4203 PF13886.6 ORX61501.1 - 3.4e-30 105.2 29.5 3.8e-30 105.1 29.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) YqhR PF11085.8 ORX61501.1 - 0.27 11.1 8.4 0.42 10.5 8.4 1.3 1 0 0 1 1 1 0 Conserved membrane protein YqhR DUF872 PF05915.12 ORX61501.1 - 1.5 9.0 4.8 0.78 9.9 2.2 1.9 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF373 PF04123.13 ORX61501.1 - 5.6 6.3 15.3 0.18 11.2 5.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF373) Got1 PF04178.12 ORX61502.1 - 2.4e-16 60.2 12.8 2.8e-16 59.9 12.8 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family Ras PF00071.22 ORX61503.1 - 1e-20 73.9 0.1 1.3e-20 73.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX61503.1 - 4.4e-10 39.8 0.1 1e-09 38.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PglZ PF08665.12 ORX61503.1 - 0.0072 16.4 0.1 0.0086 16.2 0.1 1.2 1 0 0 1 1 1 1 PglZ domain Arf PF00025.21 ORX61503.1 - 0.0073 15.8 0.1 0.009 15.5 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family LuxT_C PF18285.1 ORX61503.1 - 0.018 15.5 0.0 0.066 13.7 0.0 1.7 1 1 1 2 2 2 0 Tetracycline repressor LuxT C-terminal domain DUF2235 PF09994.9 ORX61504.1 - 2.6e-63 214.0 0.0 3.2e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) BUD22 PF09073.10 ORX61506.1 - 4.2e-24 85.7 56.5 3.3e-12 46.5 29.8 2.3 1 1 1 2 2 2 2 BUD22 AAA_26 PF13500.6 ORX61506.1 - 0.064 13.1 5.0 0.034 13.9 1.3 2.1 2 0 0 2 2 2 0 AAA domain fn3_2 PF16893.5 ORX61507.1 - 2.3e-33 114.2 0.2 4e-33 113.4 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 ORX61507.1 - 5.3e-28 96.7 0.1 8.3e-28 96.1 0.1 1.3 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 ORX61507.1 - 1.8e-12 47.4 0.0 4.1e-12 46.3 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ORX61507.1 - 2.1e-12 46.8 0.0 3.6e-12 46.1 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain fn3 PF00041.21 ORX61507.1 - 4.3e-06 27.0 0.7 2e-05 24.8 0.2 2.3 2 1 0 2 2 2 1 Fibronectin type III domain DUF3006 PF11213.8 ORX61507.1 - 0.00075 19.7 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 ORX61507.1 - 0.00096 19.5 0.0 0.0027 18.1 0.0 1.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 ORX61507.1 - 0.082 13.0 0.1 0.23 11.5 0.1 1.9 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain fn3_4 PF16794.5 ORX61507.1 - 0.11 12.4 0.1 0.26 11.2 0.0 1.7 1 1 0 1 1 1 0 Fibronectin-III type domain N_BRCA1_IG PF16158.5 ORX61507.1 - 0.12 13.1 0.0 0.3 11.8 0.0 1.7 1 0 0 1 1 1 0 Ig-like domain from next to BRCA1 gene dCMP_cyt_deam_1 PF00383.23 ORX61508.1 - 5.7e-19 67.9 0.2 8.9e-19 67.3 0.2 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ORX61508.1 - 5.4e-06 26.2 0.0 8.2e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 ORX61508.1 - 1.3e-05 25.8 0.0 3.3e-05 24.4 0.0 1.7 1 1 0 1 1 1 1 AAA domain DUF1534 PF07551.11 ORX61508.1 - 0.14 11.9 0.1 0.29 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1534) Pkinase PF00069.25 ORX61509.1 - 5.7e-67 225.9 0.0 8.3e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61509.1 - 1.5e-36 126.0 0.0 2.2e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61509.1 - 2.9e-10 39.9 0.0 4.6e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX61509.1 - 0.00011 21.6 0.2 0.00026 20.4 0.2 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX61509.1 - 0.0005 19.0 0.0 0.0005 19.0 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ORX61509.1 - 0.017 15.0 0.3 0.041 13.8 0.3 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX61509.1 - 0.022 13.7 0.1 0.033 13.1 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 ORX61509.1 - 0.047 12.7 0.1 0.073 12.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Sulfate_transp PF00916.20 ORX61510.1 - 3.7e-112 374.8 21.0 5e-112 374.4 21.0 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX61510.1 - 9.3e-10 38.2 0.0 1.6e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 STAS domain STAS_2 PF13466.6 ORX61510.1 - 0.004 17.5 0.0 0.0096 16.2 0.0 1.6 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX61510.1 - 0.0061 16.9 1.8 0.0061 16.9 1.8 3.7 3 1 0 3 3 3 1 Molybdate transporter of MFS superfamily Bys1 PF04681.12 ORX61510.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Blastomyces yeast-phase-specific protein WH1 PF00568.23 ORX61511.1 - 1.2e-23 83.1 0.4 1.8e-23 82.6 0.4 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 ORX61511.1 - 1.6e-06 27.7 1.4 3.6e-06 26.6 1.4 1.5 1 0 0 1 1 1 1 WH2 motif PBD PF00786.28 ORX61511.1 - 8e-06 26.1 0.1 1.6e-05 25.1 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain DCP1 PF06058.13 ORX61511.1 - 0.054 13.4 0.0 0.077 12.9 0.0 1.2 1 0 0 1 1 1 0 Dcp1-like decapping family AC_N PF16214.5 ORX61511.1 - 0.22 10.6 1.6 0.3 10.2 1.6 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region PFU PF09070.11 ORX61512.1 - 2.1e-36 124.6 0.5 3.7e-36 123.8 0.5 1.4 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 ORX61512.1 - 4.5e-27 95.0 1.8 6.4e-27 94.5 1.8 1.2 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 ORX61512.1 - 1e-22 80.0 8.1 2e-06 28.4 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat BBS2_Mid PF14783.6 ORX61512.1 - 0.0027 17.7 0.0 1.3 9.1 0.0 3.1 2 1 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region PUL PF08324.11 ORX61513.1 - 2.2e-11 43.6 0.2 2.4e-11 43.4 0.2 1.0 1 0 0 1 1 1 1 PUL domain G-alpha PF00503.20 ORX61514.1 - 4.4e-115 384.6 5.2 5.3e-115 384.4 5.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX61514.1 - 6.3e-17 61.6 0.6 4.4e-11 42.5 0.1 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ORX61514.1 - 0.00038 19.9 2.5 0.034 13.5 0.1 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ORX61514.1 - 0.0046 17.2 0.3 1.6 9.0 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ORX61514.1 - 0.013 15.2 0.0 0.035 13.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain zf-CHC2 PF01807.20 ORX61514.1 - 0.017 14.9 0.2 0.083 12.7 0.1 2.2 2 0 0 2 2 2 0 CHC2 zinc finger MMS19_C PF12460.8 ORX61514.1 - 0.028 13.5 0.1 0.072 12.2 0.1 1.6 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal MMR_HSR1 PF01926.23 ORX61514.1 - 0.031 14.3 0.0 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 ORX61514.1 - 0.035 13.5 0.1 0.083 12.2 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family DinB PF05163.12 ORX61515.1 - 0.0003 20.7 0.2 0.00036 20.5 0.2 1.1 1 0 0 1 1 1 1 DinB family DinB_2 PF12867.7 ORX61515.1 - 0.0031 18.0 0.8 0.0041 17.6 0.8 1.2 1 0 0 1 1 1 1 DinB superfamily HAD PF12710.7 ORX61516.1 - 7.1e-17 62.4 0.0 1.2e-16 61.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ORX61516.1 - 1.7e-13 51.4 0.7 2.9e-13 50.6 0.7 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX61516.1 - 1e-10 41.8 0.2 8.4e-10 38.8 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase SPX PF03105.19 ORX61516.1 - 1e-08 35.6 5.1 0.00038 20.5 0.0 3.5 3 1 1 4 4 4 2 SPX domain ACT_6 PF13740.6 ORX61516.1 - 4.4e-08 33.0 0.5 1.4e-07 31.4 0.0 2.1 2 0 0 2 2 2 1 ACT domain Put_Phosphatase PF06888.12 ORX61516.1 - 1.3e-05 24.8 0.0 0.0097 15.3 0.0 2.2 2 0 0 2 2 2 2 Putative Phosphatase HAD_2 PF13419.6 ORX61516.1 - 0.0031 17.6 0.3 1.3 9.1 0.1 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase DUF705 PF05152.12 ORX61516.1 - 0.051 13.0 0.1 0.12 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF705) DUF5456 PF17539.2 ORX61517.1 - 0.011 15.6 0.0 0.016 15.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5456) HTH_Tnp_ISL3 PF13542.6 ORX61517.1 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_23 PF13384.6 ORX61517.1 - 0.16 11.8 0.1 7.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Homeodomain-like domain Prok-RING_1 PF14446.6 ORX61518.1 - 0.17 11.9 1.2 0.3 11.0 1.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 OSR1_C PF12202.8 ORX61519.1 - 0.026 14.8 0.1 0.064 13.5 0.1 1.7 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain CorA PF01544.18 ORX61520.1 - 2.5e-07 30.3 1.5 4.3e-07 29.6 1.5 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Siah-Interact_N PF09032.11 ORX61520.1 - 0.011 16.1 0.7 0.027 14.8 0.7 1.7 1 0 0 1 1 1 0 Siah interacting protein, N terminal APH PF01636.23 ORX61520.1 - 0.04 13.8 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family UPF0449 PF15136.6 ORX61520.1 - 0.066 13.7 1.6 12 6.4 0.5 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Dynactin_p22 PF07426.11 ORX61520.1 - 0.089 12.6 2.5 0.12 12.2 0.3 2.1 2 0 0 2 2 2 0 Dynactin subunit p22 Ank_3 PF13606.6 ORX61521.1 - 2.3e-12 45.9 0.1 0.00052 20.2 0.0 5.6 5 0 0 5 5 4 2 Ankyrin repeat Ank_2 PF12796.7 ORX61521.1 - 6.9e-12 45.8 4.2 0.00019 22.0 0.2 3.9 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 ORX61521.1 - 2.4e-11 43.6 5.4 0.00014 22.1 0.1 4.3 4 0 0 4 4 3 2 Ankyrin repeat Ank_5 PF13857.6 ORX61521.1 - 1.8e-08 34.4 4.4 0.002 18.4 0.5 3.2 3 0 0 3 3 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX61521.1 - 3.8e-08 33.7 3.7 0.00011 22.7 0.1 4.2 3 2 2 5 5 4 3 Ankyrin repeats (many copies) Spc7 PF08317.11 ORX61521.1 - 0.014 14.3 11.5 0.033 13.1 8.6 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DHC PF09626.10 ORX61521.1 - 0.015 16.2 1.3 0.038 14.9 0.4 2.2 2 0 0 2 2 1 0 Dihaem cytochrome c COG2 PF06148.11 ORX61521.1 - 0.026 14.6 1.9 0.076 13.1 1.9 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 KilA-N PF04383.13 ORX61521.1 - 0.041 13.7 4.0 0.077 12.9 0.1 3.2 3 1 0 3 3 3 0 KilA-N domain Exonuc_VII_L PF02601.15 ORX61521.1 - 0.068 12.7 5.1 0.037 13.6 2.5 1.9 2 0 0 2 2 2 0 Exonuclease VII, large subunit Rx_N PF18052.1 ORX61521.1 - 0.071 13.4 3.7 0.19 12.0 3.7 1.7 1 0 0 1 1 1 0 Rx N-terminal domain DUF1993 PF09351.10 ORX61521.1 - 0.14 12.3 1.0 0.47 10.6 1.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) DUF1043 PF06295.12 ORX61521.1 - 0.3 11.1 4.8 0.93 9.5 4.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) OmpH PF03938.14 ORX61521.1 - 0.39 11.0 12.4 0.18 12.2 9.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SesA PF17107.5 ORX61521.1 - 0.48 10.6 7.5 0.15 12.3 1.7 2.8 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases GrpE PF01025.19 ORX61521.1 - 0.49 10.0 8.0 0.27 10.9 4.3 2.2 2 0 0 2 2 2 0 GrpE GAS PF13851.6 ORX61521.1 - 0.5 9.7 10.9 0.23 10.8 7.2 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 ORX61521.1 - 0.86 10.0 16.4 0.044 14.2 10.4 1.9 2 1 0 2 2 1 0 Fez1 YabA PF06156.13 ORX61521.1 - 0.86 10.3 4.6 6.1 7.5 3.5 2.5 2 0 0 2 2 2 0 Initiation control protein YabA FapA PF03961.13 ORX61521.1 - 0.95 8.0 6.0 0.35 9.4 2.3 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A APG6_N PF17675.1 ORX61521.1 - 1.1 9.8 11.2 2.7 8.5 6.6 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF1664 PF07889.12 ORX61521.1 - 1.5 8.9 4.5 3.7 7.6 3.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 ORX61521.1 - 1.9 6.3 3.8 2.9 5.7 3.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 ORX61521.1 - 2.6 8.1 13.2 1.5 8.9 10.9 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 ORX61521.1 - 2.7 7.1 3.8 5.2 6.2 3.8 1.4 1 0 0 1 1 1 0 TMPIT-like protein TBCA PF02970.16 ORX61521.1 - 5.7 7.3 9.9 4.1 7.8 5.8 2.8 2 0 0 2 2 2 0 Tubulin binding cofactor A bZIP_1 PF00170.21 ORX61521.1 - 7.2 6.8 12.3 12 6.1 4.6 2.7 2 0 0 2 2 2 0 bZIP transcription factor PTR2 PF00854.21 ORX61522.1 - 1.4e-90 304.0 8.9 2e-90 303.5 8.9 1.2 1 0 0 1 1 1 1 POT family CCSMST1 PF15013.6 ORX61522.1 - 0.1 12.8 0.0 0.35 11.1 0.0 1.9 1 0 0 1 1 1 0 CCSMST1 family COX6A PF02046.15 ORX61523.1 - 8.3e-26 90.7 3.9 9.8e-26 90.4 3.9 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa RNA_Me_trans PF04252.13 ORX61523.1 - 0.23 11.0 0.3 0.34 10.5 0.3 1.2 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase NDUF_B7 PF05676.13 ORX61524.1 - 4.1e-28 96.9 4.4 4.7e-28 96.7 4.4 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 ORX61524.1 - 0.0048 16.9 2.7 0.0059 16.6 2.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like AHL_synthase PF17327.2 ORX61524.1 - 0.079 12.0 0.1 0.082 11.9 0.1 1.0 1 0 0 1 1 1 0 Acyl homoserine lactone synthase DUF3684 PF12449.8 ORX61525.1 - 1.9e-290 966.4 0.2 4.2e-282 938.8 0.2 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 ORX61525.1 - 7.8e-05 22.5 0.0 0.00017 21.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CUE PF02845.16 ORX61525.1 - 0.14 11.9 0.0 0.36 10.6 0.0 1.8 1 0 0 1 1 1 0 CUE domain Glyco_hydro_18 PF00704.28 ORX61526.1 - 1.1e-23 84.4 0.7 1.1e-22 81.2 0.7 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DMRL_synthase PF00885.19 ORX61528.1 - 3.8e-49 166.1 0.1 4.7e-49 165.8 0.1 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase ATP-synt_ab PF00006.25 ORX61529.1 - 1.2e-63 214.7 0.0 2.1e-63 213.8 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ORX61529.1 - 1.6e-23 83.0 2.4 3.9e-23 81.7 2.0 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain NACHT PF05729.12 ORX61529.1 - 0.0085 16.0 0.1 0.02 14.8 0.0 1.6 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 ORX61529.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ORX61529.1 - 0.012 14.8 1.1 0.016 14.4 0.1 1.6 2 0 0 2 2 2 0 NB-ARC domain AAA_16 PF13191.6 ORX61529.1 - 0.019 15.3 0.1 0.067 13.6 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX61529.1 - 0.024 15.1 0.1 0.36 11.2 0.0 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ORX61529.1 - 0.029 14.3 0.0 0.074 13.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 ORX61529.1 - 0.034 13.5 0.1 0.065 12.6 0.1 1.5 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 ORX61529.1 - 0.053 13.4 0.6 0.36 10.7 0.6 2.2 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA_19 PF13245.6 ORX61529.1 - 0.076 13.3 0.7 0.3 11.4 0.2 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ORX61529.1 - 0.13 12.6 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP-synt_DE_N PF02823.16 ORX61530.1 - 7.8e-17 61.0 0.1 1.1e-16 60.5 0.1 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain PSP PF04046.16 ORX61531.1 - 1.4e-08 34.4 0.9 1.4e-08 34.4 0.9 1.9 2 0 0 2 2 2 1 PSP Mito_carr PF00153.27 ORX61532.1 - 1e-53 179.2 2.9 6.8e-18 64.4 0.1 3.5 3 1 0 3 3 3 3 Mitochondrial carrier protein WW PF00397.26 ORX61533.1 - 7.7e-08 32.3 1.8 7.7e-08 32.3 1.8 2.2 3 0 0 3 3 3 1 WW domain DUF2076 PF09849.9 ORX61533.1 - 0.011 15.8 13.7 0.011 15.8 13.7 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4748 PF15932.5 ORX61534.1 - 0.13 12.1 0.3 0.22 11.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Nucleopor_Nup85 PF07575.13 ORX61536.1 - 1.7e-17 63.3 2.7 2.1e-17 62.9 2.7 1.1 1 0 0 1 1 1 1 Nup85 Nucleoporin G-patch PF01585.23 ORX61537.1 - 4.9e-16 58.3 0.6 1.1e-15 57.2 0.6 1.7 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX61537.1 - 2e-07 31.0 1.6 2e-07 31.0 1.6 3.7 2 1 0 2 2 1 1 G-patch domain SDA1 PF05285.12 ORX61537.1 - 8.5e-05 22.1 25.5 0.00011 21.8 25.5 1.1 1 0 0 1 1 1 1 SDA1 SR-25 PF10500.9 ORX61537.1 - 0.00026 20.7 26.2 0.00037 20.2 26.2 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nop14 PF04147.12 ORX61537.1 - 0.0014 16.9 20.0 0.0015 16.9 20.0 1.0 1 0 0 1 1 1 1 Nop14-like family YL1 PF05764.13 ORX61537.1 - 0.0024 18.0 25.5 0.0029 17.8 25.5 1.1 1 0 0 1 1 1 1 YL1 nuclear protein RR_TM4-6 PF06459.12 ORX61537.1 - 0.0059 16.5 15.8 0.0072 16.2 15.8 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 GAGA_bind PF06217.12 ORX61537.1 - 0.011 16.0 12.0 0.012 16.0 12.0 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 ORX61537.1 - 0.013 13.9 23.0 0.015 13.6 23.0 1.1 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 ORX61537.1 - 0.016 13.6 14.9 0.02 13.4 14.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF2052 PF09747.9 ORX61537.1 - 0.017 15.3 14.3 0.022 14.9 14.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 ORX61537.1 - 0.054 12.3 11.8 0.061 12.1 11.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Senescence_reg PF04520.13 ORX61537.1 - 0.13 13.1 11.7 0.21 12.4 11.7 1.3 1 0 0 1 1 1 0 Senescence regulator DUF5308 PF17233.2 ORX61537.1 - 0.23 11.7 5.7 0.35 11.1 5.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) DUF913 PF06025.12 ORX61537.1 - 0.25 10.3 10.6 0.32 9.9 10.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RP-C_C PF11800.8 ORX61537.1 - 0.27 11.3 7.9 0.41 10.7 7.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region RNA_polI_A34 PF08208.11 ORX61537.1 - 0.28 11.3 40.2 0.42 10.7 40.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF2722 PF10846.8 ORX61537.1 - 0.55 9.1 18.6 0.7 8.8 18.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) YqfQ PF14181.6 ORX61537.1 - 0.97 9.6 20.2 1.6 8.9 20.2 1.3 1 0 0 1 1 1 0 YqfQ-like protein SLC12 PF03522.15 ORX61537.1 - 1.1 8.3 15.0 1.2 8.0 15.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 ORX61537.1 - 1.2 7.9 18.2 1.3 7.7 18.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ORX61537.1 - 1.5 7.1 11.9 1.7 6.9 11.9 1.1 1 0 0 1 1 1 0 Menin SpoIIP PF07454.11 ORX61537.1 - 1.8 7.9 16.0 2.6 7.4 16.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Zip PF02535.22 ORX61537.1 - 2.1 7.5 11.2 2.6 7.2 11.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4551 PF15087.6 ORX61537.1 - 2.6 6.8 9.1 3.2 6.5 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Connexin PF00029.19 ORX61537.1 - 2.9 7.6 11.9 4.5 7.0 11.9 1.4 1 0 0 1 1 1 0 Connexin CobT PF06213.12 ORX61537.1 - 2.9 7.2 22.1 4 6.8 22.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ORX61537.1 - 3 6.5 15.6 3.5 6.3 15.6 1.1 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.8 ORX61537.1 - 3.2 7.7 7.5 4.3 7.2 7.5 1.2 1 0 0 1 1 1 0 N-glycosylation protein FGF-BP1 PF06473.12 ORX61537.1 - 3.7 7.3 17.4 5.3 6.8 17.4 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Neur_chan_memb PF02932.16 ORX61537.1 - 3.8 7.5 9.4 4.2 7.3 9.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NARP1 PF12569.8 ORX61537.1 - 4.3 6.1 28.5 5.4 5.8 28.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PPL5 PF18168.1 ORX61537.1 - 5.5 6.2 17.6 8.2 5.6 17.6 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Hid1 PF12722.7 ORX61537.1 - 6 4.9 12.7 6.6 4.7 12.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TP53IP5 PF15331.6 ORX61537.1 - 6 7.0 15.9 8 6.5 15.9 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 ALMT PF11744.8 ORX61537.1 - 6.4 5.5 12.1 7.5 5.3 12.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AF-4 PF05110.13 ORX61537.1 - 8.5 4.3 25.8 10 4.0 25.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TRAP_alpha PF03896.16 ORX61537.1 - 9.3 5.4 10.8 13 4.9 10.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Spc7 PF08317.11 ORX61538.1 - 0.071 12.0 42.4 0.063 12.2 17.5 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein ApoO PF09769.9 ORX61538.1 - 3.7 7.5 14.9 1.6 8.7 0.4 4.0 1 1 1 3 3 3 0 Apolipoprotein O SOBP PF15279.6 ORX61538.1 - 3.8 8.0 11.9 5.2 7.6 11.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein 5_nucleotid PF05761.14 ORX61538.1 - 7.2 5.4 27.4 0.012 14.5 5.9 2.6 1 1 2 3 3 3 0 5' nucleotidase family DUF2935 PF11155.8 ORX61538.1 - 10 6.5 15.5 13 6.1 1.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) Pkinase PF00069.25 ORX61539.1 - 3.1e-19 69.4 0.0 4.1e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ORX61539.1 - 0.00028 19.8 0.0 0.0004 19.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX61539.1 - 0.0014 18.6 0.0 0.041 13.8 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Tachylectin PF14517.6 ORX61539.1 - 0.018 14.6 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Tachylectin Pkinase_Tyr PF07714.17 ORX61539.1 - 0.019 14.3 0.0 0.033 13.5 0.0 1.5 1 1 0 1 1 1 0 Protein tyrosine kinase MFS_1 PF07690.16 ORX61540.1 - 7.7e-41 140.2 35.5 7.7e-41 140.2 35.5 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily OrfB_Zn_ribbon PF07282.11 ORX61541.1 - 1.4e-09 37.7 0.7 2.7e-09 36.8 0.7 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX61541.1 - 0.0061 16.6 1.3 0.01 15.8 1.3 1.4 1 0 0 1 1 1 1 Double zinc ribbon RNHCP PF12647.7 ORX61541.1 - 0.025 14.5 0.8 0.038 14.0 0.8 1.3 1 0 0 1 1 1 0 RNHCP domain PAS_4 PF08448.10 ORX61541.1 - 0.064 13.5 2.1 1.6 9.0 0.3 2.4 1 1 2 3 3 3 0 PAS fold DUF5082 PF16888.5 ORX61541.1 - 0.1 12.9 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) AbiJ_NTD3 PF18860.1 ORX61541.1 - 0.11 12.1 0.0 0.28 10.7 0.0 1.6 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 NAD_binding_4 PF07993.12 ORX61544.1 - 4.3e-43 147.3 0.0 4.3e-43 147.3 0.0 2.0 2 0 0 2 2 2 1 Male sterility protein Epimerase PF01370.21 ORX61544.1 - 5e-05 22.9 0.0 0.00016 21.2 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sterile PF03015.19 ORX61544.1 - 6.7e-05 23.0 0.0 0.00021 21.4 0.0 1.8 1 0 0 1 1 1 1 Male sterility protein NuA4 PF09340.10 ORX61545.1 - 1e-21 76.6 0.4 1e-21 76.6 0.4 2.0 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 DUF4691 PF15762.5 ORX61545.1 - 0.87 9.7 6.9 0.18 11.9 3.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4691) Aminotran_1_2 PF00155.21 ORX61546.1 - 6.8e-26 91.3 0.0 7.9e-26 91.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ORX61546.1 - 1.5e-12 47.0 0.0 2.4e-12 46.3 0.0 1.2 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Ctr PF04145.15 ORX61547.1 - 1.8e-28 100.1 0.1 2.1e-28 99.8 0.1 1.0 1 0 0 1 1 1 1 Ctr copper transporter family TraL PF07178.11 ORX61547.1 - 0.069 13.6 2.7 0.76 10.3 0.4 2.2 2 0 0 2 2 2 0 TraL protein FAD_binding_8 PF08022.12 ORX61548.1 - 1.5e-17 63.6 0.0 2.7e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ORX61548.1 - 2.8e-14 53.3 9.3 5.8e-14 52.3 8.4 2.0 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 ORX61548.1 - 1.2e-07 32.0 0.0 1.1e-06 28.9 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ORX61548.1 - 0.035 14.8 0.1 1.4 9.6 0.0 2.8 3 0 0 3 3 3 0 Oxidoreductase NAD-binding domain ACP_syn_III_C PF08541.10 ORX61548.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal TMEM43 PF07787.12 ORX61548.1 - 0.31 10.4 2.5 6.8 6.0 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 43 DUF4405 PF14358.6 ORX61548.1 - 2.4 8.8 7.6 4.7 7.8 0.3 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4405) Grp7_allergen PF16984.5 ORX61549.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Group 7 allergen tRNA-synt_2 PF00152.20 ORX61550.1 - 7.1e-89 298.0 0.0 8.5e-89 297.7 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ORX61550.1 - 6.3e-09 35.7 0.0 1.1e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ORX61550.1 - 0.044 13.3 0.1 1.8 8.0 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) Porin_3 PF01459.22 ORX61551.1 - 5.1e-69 232.7 2.9 5.9e-69 232.5 2.9 1.0 1 0 0 1 1 1 1 Eukaryotic porin zf-CCCH PF00642.24 ORX61552.1 - 1.7e-12 46.9 13.8 2e-06 27.6 3.0 2.6 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 ORX61552.1 - 1.1e-05 25.2 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 ORX61552.1 - 0.039 14.0 2.6 0.039 14.0 2.6 2.7 2 0 0 2 2 2 0 Zinc finger domain Torus PF16131.5 ORX61552.1 - 0.041 14.6 2.6 0.21 12.3 0.2 2.7 2 0 0 2 2 2 0 Torus domain zf-CCCH_3 PF15663.5 ORX61552.1 - 0.2 11.9 5.0 1.6 9.0 0.2 2.9 3 0 0 3 3 3 0 Zinc-finger containing family DUF92 PF01940.16 ORX61553.1 - 1.2e-76 257.2 2.7 1.4e-76 257.0 2.7 1.0 1 0 0 1 1 1 1 Integral membrane protein DUF92 Methyltransf_18 PF12847.7 ORX61553.1 - 0.12 12.4 0.0 1.9 8.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain U3_assoc_6 PF08640.11 ORX61554.1 - 3.1e-27 94.4 6.9 3.1e-27 94.4 6.9 2.6 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 TPR_14 PF13428.6 ORX61554.1 - 6.2e-08 32.8 5.8 0.1 13.5 0.5 5.3 4 1 0 4 4 4 2 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX61554.1 - 1e-05 24.9 14.5 0.0011 18.2 0.7 4.3 3 1 1 4 4 4 2 NRDE-2, necessary for RNA interference TPR_17 PF13431.6 ORX61554.1 - 1.4e-05 25.1 0.4 1.6 9.3 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX61554.1 - 0.00036 21.0 6.1 0.4 11.2 0.2 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX61554.1 - 0.00077 19.1 0.0 0.28 10.9 0.1 2.8 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.6 ORX61554.1 - 0.025 15.2 0.9 8.7 7.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61554.1 - 0.26 11.5 4.2 5.1 7.5 0.3 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX61554.1 - 0.33 10.8 2.8 2 8.4 0.3 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat S1 PF00575.23 ORX61555.1 - 0.53 10.7 3.6 0.79 10.1 3.6 1.4 1 0 0 1 1 1 0 S1 RNA binding domain RR_TM4-6 PF06459.12 ORX61555.1 - 8 6.2 16.7 9.3 6.0 16.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pkinase PF00069.25 ORX61556.1 - 5e-59 199.8 0.0 6.8e-59 199.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61556.1 - 8.9e-36 123.5 0.0 1.4e-35 122.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX61556.1 - 0.087 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FYVE PF01363.21 ORX61557.1 - 1.7e-13 50.5 12.9 2.6e-13 49.9 12.9 1.3 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 ORX61557.1 - 0.02 15.0 14.2 0.02 15.0 14.2 1.9 2 0 0 2 2 2 0 AN1-like Zinc finger E1-E2_ATPase PF00122.20 ORX61559.1 - 5.9e-48 162.8 3.1 5.9e-48 162.8 3.1 3.4 5 0 0 5 5 5 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX61559.1 - 1.6e-34 119.2 3.1 1.6e-34 119.2 3.1 2.3 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX61559.1 - 7.5e-21 74.0 0.0 1.5e-20 73.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX61559.1 - 2e-18 67.4 0.0 1.4e-16 61.4 0.0 3.1 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX61559.1 - 3.4e-17 61.9 0.2 3.2e-16 58.7 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX61559.1 - 0.00079 19.2 1.1 0.002 17.9 0.6 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Mito_carr PF00153.27 ORX61560.1 - 2.4e-21 75.4 0.2 3.8e-07 29.9 0.0 5.1 4 1 0 4 4 4 4 Mitochondrial carrier protein TPMT PF05724.11 ORX61561.1 - 2.1e-25 89.6 0.0 2.7e-25 89.3 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_25 PF13649.6 ORX61561.1 - 5.3e-08 33.5 0.0 7.7e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX61561.1 - 3.2e-06 27.7 0.0 4.6e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX61561.1 - 3.7e-06 26.8 0.0 5.2e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX61561.1 - 0.00031 21.4 0.0 0.00043 21.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX61561.1 - 0.015 15.1 0.0 0.022 14.6 0.0 1.3 1 1 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 ORX61562.1 - 1.6e-69 233.7 0.0 2.1e-69 233.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.15 ORX61562.1 - 0.00038 20.2 0.0 0.00074 19.3 0.0 1.5 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase PrmA PF06325.13 ORX61562.1 - 0.012 15.0 0.0 0.29 10.5 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) TRM PF02005.16 ORX61562.1 - 0.025 13.8 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltransf_23 PF13489.6 ORX61562.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S17 PF00366.20 ORX61563.1 - 6.6e-28 96.6 1.0 7.6e-28 96.4 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 Complex1_LYR PF05347.15 ORX61564.1 - 6.4e-14 51.8 0.2 8.6e-14 51.3 0.2 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX61564.1 - 0.011 16.5 0.2 0.014 16.1 0.2 1.1 1 0 0 1 1 1 0 Complex1_LYR-like DUF1206 PF06724.11 ORX61565.1 - 2.7e-13 49.8 19.4 2.1e-09 37.3 2.1 4.0 2 1 2 4 4 4 2 Domain of Unknown Function (DUF1206) SMC_N PF02463.19 ORX61566.1 - 5.4e-27 94.7 0.0 1.1e-26 93.6 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX61566.1 - 5.5e-12 46.6 3.9 5.5e-12 46.6 3.9 5.6 3 2 2 5 5 2 1 AAA domain AAA_15 PF13175.6 ORX61566.1 - 6.4e-08 32.7 5.9 6.4e-08 32.7 5.9 3.9 2 2 0 2 2 1 1 AAA ATPase domain AAA_21 PF13304.6 ORX61566.1 - 1.2e-06 28.6 9.4 0.0049 16.7 0.0 4.0 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system BST2 PF16716.5 ORX61566.1 - 0.0004 20.9 2.0 0.0004 20.9 2.0 7.2 4 2 4 8 8 6 2 Bone marrow stromal antigen 2 AAA_29 PF13555.6 ORX61566.1 - 0.0044 16.7 0.0 0.0088 15.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Spc7 PF08317.11 ORX61566.1 - 0.0064 15.4 73.8 0.27 10.1 21.6 5.4 2 2 1 4 4 4 4 Spc7 kinetochore protein ATG16 PF08614.11 ORX61566.1 - 0.0073 16.5 6.5 0.0073 16.5 6.5 7.5 3 2 3 7 7 7 1 Autophagy protein 16 (ATG16) Takusan PF04822.13 ORX61566.1 - 0.017 15.0 1.0 0.017 15.0 1.0 5.0 6 0 0 6 6 5 0 Takusan SMC_hinge PF06470.13 ORX61566.1 - 0.019 15.3 0.0 0.07 13.4 0.0 2.1 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain AAA_13 PF13166.6 ORX61566.1 - 0.041 12.5 65.2 0.015 14.0 18.9 5.8 3 2 2 5 5 5 0 AAA domain DUF1664 PF07889.12 ORX61566.1 - 0.045 13.8 39.2 0.097 12.7 0.4 7.5 4 2 4 8 8 8 0 Protein of unknown function (DUF1664) DUF5499 PF17603.2 ORX61566.1 - 0.1 13.2 1.6 0.39 11.4 0.4 2.7 2 0 0 2 2 1 0 Family of unknown function (DUF5499) AAA_16 PF13191.6 ORX61566.1 - 0.72 10.2 0.0 0.72 10.2 0.0 4.0 3 2 0 3 3 2 0 AAA ATPase domain AAA_22 PF13401.6 ORX61566.1 - 1.4 9.2 4.8 3.9 7.7 0.0 3.8 4 0 0 4 4 4 0 AAA domain GPI-anchored PF10342.9 ORX61567.1 - 1.6e-13 51.2 0.0 2.2e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family C2 PF00168.30 ORX61568.1 - 7.2e-20 71.2 0.0 1.2e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain Abhydrolase_6 PF12697.7 ORX61569.1 - 7e-16 59.5 6.5 8.5e-16 59.2 6.5 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX61569.1 - 1.8e-14 53.6 0.0 2.3e-14 53.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ORX61569.1 - 7.9e-12 45.3 0.3 4.3e-11 42.9 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ORX61569.1 - 0.00082 19.2 0.2 0.41 10.4 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Thioesterase PF00975.20 ORX61569.1 - 0.0072 16.5 0.3 0.015 15.5 0.3 1.5 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 ORX61569.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX61569.1 - 0.018 14.5 0.0 1.5 8.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family PGAP1 PF07819.13 ORX61569.1 - 0.029 14.1 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_5 PF12695.7 ORX61569.1 - 0.033 13.9 0.0 1.7 8.4 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family EamA PF00892.20 ORX61570.1 - 3.9e-06 27.1 10.4 2.9e-05 24.2 10.4 1.9 1 1 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 ORX61570.1 - 2e-05 24.6 0.8 2.5e-05 24.3 0.8 1.2 1 0 0 1 1 1 1 Putative transmembrane family 234 Multi_Drug_Res PF00893.19 ORX61570.1 - 0.008 16.8 0.8 0.008 16.8 0.8 1.9 2 0 0 2 2 2 1 Small Multidrug Resistance protein UAA PF08449.11 ORX61570.1 - 0.015 14.5 2.7 0.018 14.2 2.7 1.1 1 0 0 1 1 1 0 UAA transporter family Glyco_hydro_31 PF01055.26 ORX61571.1 - 2.3e-147 491.8 9.7 2.3e-147 491.8 9.7 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ORX61571.1 - 1.7e-23 82.7 1.2 1.1e-22 80.1 0.2 2.5 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 ORX61571.1 - 1.5e-08 34.7 0.1 4.6e-08 33.2 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Kelch_6 PF13964.6 ORX61572.1 - 2.1e-26 91.3 10.4 1.4e-07 31.6 0.0 6.5 5 1 1 6 6 6 6 Kelch motif Kelch_4 PF13418.6 ORX61572.1 - 3e-26 91.1 3.0 3.3e-05 23.8 0.0 6.0 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX61572.1 - 6.6e-26 89.8 14.2 2.1e-06 27.5 0.0 6.6 6 0 0 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ORX61572.1 - 5.6e-25 87.1 6.6 0.00013 22.2 0.0 6.9 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX61572.1 - 2.7e-23 81.3 6.6 2.1e-11 43.2 0.1 5.8 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 ORX61572.1 - 1.6e-21 75.3 10.9 6.5e-07 29.1 0.1 6.4 6 0 0 6 6 6 5 Kelch motif TFIIS_C PF01096.18 ORX61573.1 - 9.1e-18 63.8 6.7 9.1e-18 63.8 6.7 2.9 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ORX61573.1 - 1.5e-08 34.3 0.9 1.5e-08 34.3 0.9 2.8 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 ORX61573.1 - 3.2e-05 23.8 6.8 0.0049 16.8 2.0 2.4 2 0 0 2 2 2 2 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 ORX61573.1 - 0.012 15.0 5.2 0.98 8.9 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Baculo_LEF5_C PF11792.8 ORX61573.1 - 0.016 14.9 1.7 0.036 13.7 1.7 1.7 1 0 0 1 1 1 0 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_4 PF13717.6 ORX61573.1 - 0.05 13.5 5.5 8.2 6.5 0.1 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Cys_rich_KTR PF14205.6 ORX61573.1 - 0.071 12.9 2.4 6.5 6.6 0.6 2.6 2 1 0 2 2 2 0 Cysteine-rich KTR Ribosomal_S27e PF01667.17 ORX61573.1 - 0.33 10.7 4.9 5.8 6.7 1.1 2.5 2 1 0 2 2 2 0 Ribosomal protein S27 Elf1 PF05129.13 ORX61573.1 - 0.53 10.4 7.5 0.59 10.2 0.8 2.4 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like PhnA_Zn_Ribbon PF08274.12 ORX61573.1 - 2.9 7.9 17.3 18 5.4 2.1 3.9 2 2 1 3 3 3 0 PhnA Zinc-Ribbon DUF3797 PF12677.7 ORX61573.1 - 3.3 7.7 10.4 3.1 7.8 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3797) CpXC PF14353.6 ORX61573.1 - 4.7 7.3 10.2 4.1 7.5 5.6 2.6 1 1 2 3 3 3 0 CpXC protein MSC PF09402.10 ORX61574.1 - 1.3e-25 90.6 0.1 1.9e-25 90.1 0.1 1.1 1 0 0 1 1 1 1 Man1-Src1p-C-terminal domain Mpp10 PF04006.12 ORX61574.1 - 0.2 10.1 0.2 0.4 9.1 0.0 1.5 2 0 0 2 2 2 0 Mpp10 protein THOC2_N PF16134.5 ORX61575.1 - 1.8e-105 354.0 0.0 1.8e-105 354.0 0.0 1.5 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 ORX61575.1 - 6e-74 249.0 2.5 1.1e-73 248.1 2.5 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 ORX61575.1 - 5.9e-23 80.7 0.0 1.5e-22 79.5 0.0 1.7 1 0 0 1 1 1 1 Transcription- and export-related complex subunit CDO_I PF05995.12 ORX61576.1 - 2.6e-45 153.8 0.0 1.7e-44 151.1 0.0 1.9 1 1 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 ORX61576.1 - 0.00074 19.0 0.2 0.0016 18.0 0.2 1.4 1 1 0 1 1 1 1 PCO_ADO Auxin_BP PF02041.16 ORX61576.1 - 0.036 13.7 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 Auxin binding protein SGS PF05002.15 ORX61577.1 - 0.057 13.5 0.0 0.27 11.4 0.0 2.2 1 0 0 1 1 1 0 SGS domain DUF1192 PF06698.11 ORX61577.1 - 0.74 9.9 7.2 1.1 9.4 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) Tweety PF04906.13 ORX61577.1 - 1.3 7.7 6.0 0.35 9.5 0.2 2.5 3 0 0 3 3 3 0 Tweety PhoU PF01895.19 ORX61577.1 - 2.2 8.8 13.2 1.1 9.8 0.5 4.0 5 0 0 5 5 5 0 PhoU domain TANGO2 PF05742.12 ORX61577.1 - 4.1 7.4 9.9 0.68 9.9 0.6 3.1 2 1 0 2 2 2 0 Transport and Golgi organisation 2 T3SchapCesA PF11439.8 ORX61577.1 - 5.9 7.1 7.0 1.4 9.1 0.6 3.0 3 0 0 3 3 3 0 Type III secretion system filament chaperone CesA DUF3446 PF11928.8 ORX61577.1 - 6.7 7.1 9.6 22 5.4 0.7 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain WD40 PF00400.32 ORX61578.1 - 2e-10 41.1 6.8 0.002 18.9 1.5 4.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61578.1 - 4.3e-09 36.6 0.2 0.065 13.5 0.1 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX61578.1 - 3.5e-07 29.9 0.1 0.0018 17.7 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain PQQ PF01011.21 ORX61578.1 - 0.0062 16.4 0.2 0.023 14.6 0.0 2.0 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.6 ORX61578.1 - 0.07 12.7 0.0 0.45 10.0 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain GFD1 PF17331.2 ORX61578.1 - 0.43 10.8 0.2 0.43 10.8 0.2 2.2 3 0 0 3 3 3 0 GFD1 mRNA transport factor Chitin_synth_2 PF03142.15 ORX61579.1 - 1.4e-89 301.1 2.3 1e-61 209.2 0.0 3.0 2 1 0 2 2 2 2 Chitin synthase DEK_C PF08766.11 ORX61579.1 - 0.00073 19.4 0.1 0.0013 18.6 0.1 1.4 1 0 0 1 1 1 1 DEK C terminal domain Glycos_transf_2 PF00535.26 ORX61579.1 - 0.0012 18.6 0.1 0.68 9.7 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ORX61579.1 - 0.0028 17.6 0.0 1.9 8.3 0.0 2.4 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Cyclin PF08613.11 ORX61580.1 - 1e-08 35.7 0.1 7.3e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Cyclin Cyclin_N PF00134.23 ORX61580.1 - 0.003 17.3 0.1 0.047 13.4 0.0 2.2 2 0 0 2 2 2 1 Cyclin, N-terminal domain MRP-L27 PF09809.9 ORX61584.1 - 4.2e-20 71.7 0.4 4.5e-20 71.6 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 zf-CCHC PF00098.23 ORX61585.1 - 9.4e-12 44.4 26.8 0.0014 18.6 0.8 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_4 PF14392.6 ORX61585.1 - 8.6e-05 22.2 20.5 0.11 12.3 0.8 4.2 4 0 0 4 4 4 4 Zinc knuckle zf-CCHC_2 PF13696.6 ORX61585.1 - 0.037 13.9 1.8 0.037 13.9 1.8 4.2 4 0 0 4 4 4 0 Zinc knuckle DUF916 PF06030.12 ORX61585.1 - 0.1 12.7 2.0 0.4 10.8 0.3 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) GCOM2 PF15328.6 ORX61586.1 - 2.9e-05 24.6 7.1 4.9e-05 23.8 7.1 1.5 1 1 0 1 1 1 1 Putative GRINL1B complex locus protein 2 SAC3_GANP PF03399.16 ORX61587.1 - 5.7e-101 337.8 0.1 7.4e-101 337.4 0.1 1.1 1 0 0 1 1 1 1 SAC3/GANP family zf-CHCC PF10276.9 ORX61588.1 - 2.2e-19 69.2 1.7 3.1e-19 68.7 1.7 1.2 1 0 0 1 1 1 1 Zinc-finger domain NAT PF04768.13 ORX61589.1 - 7.4e-38 129.9 0.1 2.1e-37 128.4 0.0 1.8 2 0 0 2 2 2 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 ORX61589.1 - 3.2e-30 105.5 0.0 5.6e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.24 ORX61589.1 - 4.1e-30 104.7 0.0 9.8e-30 103.5 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 ORX61589.1 - 2.8e-09 37.3 0.0 5.6e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain DapB_N PF01113.20 ORX61589.1 - 0.018 15.2 0.0 0.056 13.6 0.0 1.9 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.22 ORX61589.1 - 0.03 15.1 0.0 0.16 12.8 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Arginosuc_synth PF00764.19 ORX61590.1 - 3.6e-150 500.6 0.0 4.1e-150 500.4 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 ORX61590.1 - 0.0026 17.3 0.0 0.004 16.7 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ORX61590.1 - 0.051 12.4 0.0 0.076 11.8 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase RRM_1 PF00076.22 ORX61591.1 - 0.00011 22.0 0.0 0.00015 21.5 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX61591.1 - 0.1 12.2 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COX7C PF02935.16 ORX61594.1 - 6.1e-13 48.8 0.0 8e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Sacchrp_dh_C PF16653.5 ORX61595.1 - 2.5e-92 309.7 0.0 3.5e-92 309.3 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ORX61595.1 - 9.6e-26 90.6 1.5 1.1e-25 90.4 0.3 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ORX61595.1 - 9.3e-08 32.2 0.0 1.9e-07 31.2 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 ORX61595.1 - 0.00014 21.8 0.1 0.00014 21.8 0.1 1.6 2 0 0 2 2 2 1 NAD(P)H-binding adh_short_C2 PF13561.6 ORX61595.1 - 0.019 14.5 0.2 0.062 12.9 0.2 1.8 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase NmrA PF05368.13 ORX61595.1 - 0.026 14.1 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family AlaDh_PNT_C PF01262.21 ORX61595.1 - 0.071 12.4 0.1 0.12 11.7 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 ORX61595.1 - 0.091 13.2 0.1 0.21 12.0 0.1 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_3 PF03447.16 ORX61595.1 - 0.099 13.3 0.3 0.27 11.9 0.1 1.9 2 0 0 2 2 2 0 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ORX61595.1 - 0.1 13.0 0.8 0.17 12.3 0.0 1.8 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Iso_dh PF00180.20 ORX61596.1 - 1.2e-101 340.3 0.1 1.7e-101 339.9 0.1 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DnaJ PF00226.31 ORX61597.1 - 8.2e-09 35.5 0.2 8.2e-09 35.5 0.2 1.8 2 0 0 2 2 2 1 DnaJ domain Gamma_PGA_hydro PF05908.11 ORX61597.1 - 0.049 13.0 1.0 0.098 12.0 1.0 1.5 1 1 0 1 1 1 0 Poly-gamma-glutamate hydrolase LMBR1 PF04791.16 ORX61597.1 - 0.97 8.3 4.7 1.2 8.0 4.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Pro_isomerase PF00160.21 ORX61598.1 - 7.3e-42 143.3 0.0 1.2e-41 142.6 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ORX61598.1 - 1.7e-15 56.6 0.0 3e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L4 PF00573.22 ORX61599.1 - 9.8e-63 211.3 0.0 1.1e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family SHNi-TPR PF10516.9 ORX61600.1 - 0.0006 19.2 0.1 0.0012 18.3 0.1 1.4 1 0 0 1 1 1 1 SHNi-TPR TetR_C_13 PF16925.5 ORX61601.1 - 0.31 11.0 3.2 0.17 11.8 1.0 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Phlebovirus_NSM PF07246.11 ORX61601.1 - 0.54 9.6 2.4 0.78 9.1 2.4 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M F-box-like PF12937.7 ORX61602.1 - 3.8e-10 39.5 5.8 7.6e-05 22.5 0.4 2.4 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 ORX61602.1 - 1.2e-09 37.8 5.4 3.1e-05 23.7 0.5 2.3 2 0 0 2 2 2 2 F-box domain AF-4 PF05110.13 ORX61602.1 - 0.04 12.0 13.3 0.042 12.0 13.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FAM199X PF15814.5 ORX61602.1 - 0.043 12.9 7.7 0.053 12.6 7.7 1.1 1 0 0 1 1 1 0 Protein family FAM199X Period_C PF12114.8 ORX61602.1 - 1.4 8.4 11.1 2 8.0 11.1 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region PAP1 PF08601.10 ORX61602.1 - 7.7 6.1 13.6 9.1 5.9 13.6 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 SHNi-TPR PF10516.9 ORX61604.1 - 2.2e-11 43.0 0.3 5.5e-11 41.7 0.3 1.7 1 0 0 1 1 1 1 SHNi-TPR TPR_2 PF07719.17 ORX61604.1 - 5e-06 26.2 1.2 0.02 15.0 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX61604.1 - 5.4e-06 26.6 3.6 7.2e-05 23.0 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ORX61604.1 - 0.0012 18.6 0.9 0.0051 16.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX61604.1 - 0.0013 18.4 1.3 0.33 10.7 0.2 4.0 3 1 0 3 3 3 1 TPR repeat BLOC1_2 PF10046.9 ORX61604.1 - 0.0054 17.0 5.1 0.77 10.1 0.5 3.4 3 0 0 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 ORX61604.1 - 0.0081 16.2 3.9 0.12 12.4 2.8 2.5 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Syntaxin_2 PF14523.6 ORX61604.1 - 0.026 14.9 2.3 0.099 13.0 2.3 2.0 1 1 0 1 1 1 0 Syntaxin-like protein DUF615 PF04751.14 ORX61604.1 - 0.035 14.1 1.5 0.087 12.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF615) TPR_17 PF13431.6 ORX61604.1 - 0.049 14.0 0.2 1.9 9.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat SKA1 PF07160.12 ORX61604.1 - 0.066 13.0 10.2 1 9.2 0.0 2.7 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 1 V_ATPase_I PF01496.19 ORX61604.1 - 0.093 10.6 0.9 0.14 10.1 0.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family THOC7 PF05615.13 ORX61604.1 - 0.14 12.4 5.9 3 8.2 4.2 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 PspB PF06667.12 ORX61604.1 - 0.16 12.1 2.8 1.5 8.9 0.1 2.6 1 1 1 2 2 2 0 Phage shock protein B DUF724 PF05266.14 ORX61604.1 - 0.36 10.6 4.9 0.61 9.9 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TPR_8 PF13181.6 ORX61604.1 - 0.5 10.7 0.0 0.5 10.7 0.0 3.2 4 0 0 4 4 2 0 Tetratricopeptide repeat FAM76 PF16046.5 ORX61604.1 - 0.98 8.7 5.4 0.21 10.9 0.2 2.0 1 1 0 1 1 1 0 FAM76 protein DUF2408 PF10303.9 ORX61604.1 - 2.1 8.9 6.7 2 9.0 5.2 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) Laminin_II PF06009.12 ORX61604.1 - 2.4 8.2 11.4 2.4 8.2 0.4 2.7 2 1 1 3 3 3 0 Laminin Domain II Med9 PF07544.13 ORX61604.1 - 2.7 8.2 9.8 15 5.8 4.1 3.4 1 1 2 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Flavokinase PF01687.17 ORX61605.1 - 7.1e-38 129.3 0.0 8.3e-38 129.1 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase GntR PF00392.21 ORX61605.1 - 0.15 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family F-box-like PF12937.7 ORX61606.1 - 0.00032 20.5 0.1 0.00049 19.9 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX61606.1 - 0.0038 17.1 0.5 0.0074 16.2 0.5 1.5 1 0 0 1 1 1 1 F-box domain DUF1798 PF08807.10 ORX61606.1 - 0.13 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) SR-25 PF10500.9 ORX61606.1 - 0.39 10.3 8.2 0.52 9.9 8.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SSP160 PF06933.11 ORX61606.1 - 1.4 7.0 4.6 1.8 6.7 4.6 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 F-box PF00646.33 ORX61607.1 - 5.2e-08 32.6 0.3 1.6e-07 31.0 0.3 1.9 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ORX61607.1 - 4.3e-07 30.1 0.2 0.19 12.2 0.0 5.9 5 1 1 6 6 6 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ORX61607.1 - 1.5e-05 24.8 0.3 3.2e-05 23.7 0.3 1.6 1 0 0 1 1 1 1 F-box-like TPR_1 PF00515.28 ORX61607.1 - 0.026 14.3 0.3 0.19 11.6 0.0 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat LRR_1 PF00560.33 ORX61607.1 - 0.048 14.2 11.5 72 4.5 0.0 7.2 7 1 1 8 8 8 0 Leucine Rich Repeat TPR_9 PF13371.6 ORX61607.1 - 0.054 13.6 0.1 0.22 11.7 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat SEO_C PF14577.6 ORX61607.1 - 0.064 12.7 0.0 0.33 10.3 0.0 2.0 2 0 0 2 2 2 0 Sieve element occlusion C-terminus LRR_8 PF13855.6 ORX61607.1 - 0.11 12.2 0.2 2.7 7.8 0.0 3.4 4 0 0 4 4 4 0 Leucine rich repeat TPR_2 PF07719.17 ORX61607.1 - 0.25 11.5 2.3 0.67 10.2 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Arf PF00025.21 ORX61608.1 - 1.2e-77 259.3 0.1 1.4e-77 259.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX61608.1 - 6.9e-16 58.5 0.0 9.6e-16 58.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ORX61608.1 - 3.2e-14 52.8 0.1 3.7e-14 52.6 0.1 1.0 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ORX61608.1 - 1e-13 51.2 0.3 3.4e-09 36.3 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 ORX61608.1 - 8.2e-12 44.9 0.0 9.6e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX61608.1 - 1.4e-10 40.9 0.0 1.8e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX61608.1 - 2.1e-06 27.8 0.0 3.9e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX61608.1 - 7.3e-05 22.4 0.2 0.00063 19.3 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 ORX61608.1 - 0.003 16.6 0.5 0.2 10.6 0.2 2.8 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 ORX61608.1 - 0.0062 16.1 0.4 1.2 8.7 0.0 2.1 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ORX61608.1 - 0.011 16.3 0.0 0.017 15.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ORX61608.1 - 0.011 16.2 0.6 0.049 14.1 0.6 1.9 1 1 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 ORX61608.1 - 0.016 15.1 0.2 2.5 8.0 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Vps35 PF03635.17 ORX61609.1 - 7.4e-243 808.3 10.9 8.7e-243 808.1 10.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 EF-hand_1 PF00036.32 ORX61610.1 - 1.4e-40 133.8 14.1 1.5e-10 39.9 1.0 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX61610.1 - 7e-35 119.3 4.0 6.8e-19 68.1 0.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ORX61610.1 - 4.8e-31 106.4 13.4 4.7e-15 55.2 0.5 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ORX61610.1 - 9.1e-31 103.1 9.2 2.4e-09 36.4 0.0 4.5 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ORX61610.1 - 1.8e-25 87.3 11.6 1e-06 27.9 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ORX61610.1 - 1.4e-13 50.9 0.2 1.3e-06 28.7 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX61610.1 - 5.7e-10 39.1 1.4 0.00022 21.1 0.1 2.1 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX61610.1 - 1.1e-09 38.6 0.6 0.00022 21.5 0.1 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ORX61610.1 - 3.1e-06 27.3 3.0 0.028 14.6 0.1 3.1 1 1 2 3 3 3 2 Dockerin type I domain EFhand_Ca_insen PF08726.10 ORX61610.1 - 6.8e-05 22.9 2.3 0.00037 20.5 0.2 2.5 2 2 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 ORX61610.1 - 7.7e-05 23.5 0.1 0.00064 20.6 0.0 1.9 1 1 1 2 2 2 1 EF-hand domain Caleosin PF05042.13 ORX61610.1 - 0.00072 19.5 1.2 1.7 8.5 0.0 3.6 1 1 3 4 4 4 1 Caleosin related protein TerB PF05099.13 ORX61610.1 - 0.00087 19.3 0.8 0.4 10.6 0.0 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB DUF3349 PF11829.8 ORX61610.1 - 0.00098 19.9 0.5 3.3 8.5 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) DUF5580 PF17743.1 ORX61610.1 - 0.0028 16.3 0.0 0.0028 16.3 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) DUF2267 PF10025.9 ORX61610.1 - 0.004 17.4 0.0 0.02 15.2 0.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) UPF0154 PF03672.13 ORX61610.1 - 0.0044 17.0 0.5 0.34 11.0 0.0 3.1 3 1 0 3 3 3 1 Uncharacterised protein family (UPF0154) RNA_pol_Rpb4 PF03874.16 ORX61610.1 - 0.0048 17.2 1.4 0.66 10.3 0.1 2.9 2 1 1 3 3 3 1 RNA polymerase Rpb4 DUF4497 PF14924.6 ORX61610.1 - 0.015 15.7 0.1 0.25 11.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4497) SurA_N_2 PF13623.6 ORX61610.1 - 0.027 14.3 1.4 0.97 9.3 0.4 2.3 1 1 1 2 2 2 0 SurA N-terminal domain PY_rept_46 PF09689.10 ORX61610.1 - 0.034 14.7 1.5 3.7 8.2 0.0 2.9 2 1 0 2 2 2 0 Plasmodium yoelii repeat (PY_rept_46) DUF853 PF05872.12 ORX61610.1 - 0.046 12.3 0.1 0.17 10.4 0.0 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF853) DUF1811 PF08838.10 ORX61610.1 - 0.051 13.8 0.2 18 5.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1811) MotA_activ PF09114.10 ORX61610.1 - 0.055 13.6 0.0 0.26 11.5 0.0 2.0 2 0 0 2 2 2 0 Transcription factor MotA, activation domain dCache_2 PF08269.11 ORX61610.1 - 0.066 12.4 0.2 3.2 6.8 0.1 2.4 1 1 1 2 2 2 0 Cache domain Spore_III_AB PF09548.10 ORX61610.1 - 0.12 12.5 0.5 0.21 11.7 0.5 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) RloB PF13707.6 ORX61610.1 - 0.12 12.5 1.0 0.8 9.9 0.7 2.1 1 1 0 1 1 1 0 RloB-like protein GPHH PF16905.5 ORX61610.1 - 0.13 12.1 0.0 12 5.7 0.0 3.3 4 0 0 4 4 4 0 Voltage-dependent L-type calcium channel, IQ-associated CMD PF02627.20 ORX61610.1 - 0.18 11.9 0.2 2.2 8.4 0.0 2.5 3 0 0 3 3 3 0 Carboxymuconolactone decarboxylase family Methyltrn_RNA_3 PF02598.17 ORX61611.1 - 5.7e-76 255.7 0.0 7.2e-76 255.4 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase Mad3_BUB1_I PF08311.12 ORX61612.1 - 5.4e-42 142.7 0.6 8.6e-42 142.0 0.6 1.3 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 ORX61612.1 - 5.4e-06 26.5 0.0 8.4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein Presenilin PF01080.17 ORX61613.1 - 1.1 7.9 9.5 1.5 7.5 9.5 1.2 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 ORX61613.1 - 1.8 7.2 8.7 1.8 7.1 8.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CDC45 PF02724.14 ORX61613.1 - 1.9 6.7 9.6 2.3 6.4 9.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 ORX61613.1 - 3.4 7.6 5.7 4.1 7.4 5.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt5-NGN PF03439.13 ORX61614.1 - 8.4e-25 86.5 0.0 1.6e-24 85.6 0.0 1.5 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 ORX61614.1 - 6.1e-18 64.1 21.8 1.2e-05 25.1 0.0 6.4 6 0 0 6 6 6 3 KOW motif Spt5_N PF11942.8 ORX61614.1 - 7.6e-17 62.1 12.4 7.6e-17 62.1 12.4 2.7 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 ORX61614.1 - 5.5e-14 52.5 16.1 5.5e-14 52.5 16.1 4.2 1 1 2 3 3 3 2 Spt5 C-terminal nonapeptide repeat binding Spt4 DUF3912 PF13051.6 ORX61614.1 - 0.011 15.9 0.2 0.68 10.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) DUF2187 PF09953.9 ORX61614.1 - 0.022 14.8 3.8 0.034 14.1 0.6 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2187) PCB_OB PF17092.5 ORX61614.1 - 0.05 14.4 1.0 6.4 7.6 0.0 4.0 5 0 0 5 5 5 0 Penicillin-binding protein OB-like domain YCII PF03795.14 ORX61614.1 - 0.065 13.7 0.0 0.37 11.2 0.0 2.3 2 0 0 2 2 2 0 YCII-related domain RNA_pol_inhib PF16857.5 ORX61614.1 - 0.074 12.9 0.0 0.69 9.8 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase inhibitor Nop14 PF04147.12 ORX61614.1 - 6.1 4.9 13.5 7.5 4.6 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.32 ORX61616.1 - 9.4e-48 159.2 23.2 9.3e-09 35.8 0.0 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ORX61616.1 - 2.1e-28 99.1 2.1 2.1e-28 99.1 2.1 1.8 2 0 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ORX61616.1 - 1.9e-11 44.1 0.2 0.031 14.6 0.0 4.8 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX61616.1 - 0.00019 20.9 0.0 1.6 8.0 0.0 3.4 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ORX61616.1 - 0.0022 16.7 8.9 0.89 8.1 0.1 4.9 4 1 2 6 6 6 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX61616.1 - 0.0067 16.3 0.0 0.031 14.2 0.0 2.1 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A CITED PF04487.12 ORX61616.1 - 0.01 15.9 2.9 0.01 15.9 2.9 1.9 2 0 0 2 2 2 0 CITED SR-25 PF10500.9 ORX61616.1 - 0.036 13.7 6.1 0.086 12.4 6.1 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.12 ORX61616.1 - 2.4 6.6 9.1 4.6 5.7 9.1 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_M41 PF01434.18 ORX61617.1 - 6.3e-66 221.9 0.0 9.3e-66 221.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX61617.1 - 8.9e-44 149.1 0.0 1.7e-43 148.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX61617.1 - 6.7e-14 51.4 0.2 1.7e-13 50.1 0.2 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ORX61617.1 - 0.00064 20.2 0.3 0.018 15.4 0.1 2.9 1 1 1 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ORX61617.1 - 0.0015 18.5 0.0 0.0063 16.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) FtsH_ext PF06480.15 ORX61617.1 - 0.0021 18.4 0.0 0.013 15.9 0.0 2.3 2 0 0 2 2 2 1 FtsH Extracellular RuvB_N PF05496.12 ORX61617.1 - 0.0031 17.3 0.0 0.0069 16.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ORX61617.1 - 0.0049 17.1 0.1 0.75 10.1 0.1 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 ORX61617.1 - 0.0076 15.5 0.1 0.012 14.8 0.1 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 ORX61617.1 - 0.025 14.7 0.0 0.094 12.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 ORX61617.1 - 0.037 14.4 0.1 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ORX61617.1 - 0.075 12.8 0.1 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ORX61617.1 - 0.19 11.1 0.3 0.5 9.7 0.3 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PigN PF04987.14 ORX61618.1 - 1.1e-125 420.1 47.1 1.7e-125 419.5 47.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 ORX61618.1 - 2.3e-14 53.8 1.0 2.4e-13 50.4 1.0 2.0 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX61618.1 - 3e-07 30.2 0.2 2.1e-06 27.4 0.2 2.0 1 1 0 1 1 1 1 Sulfatase DUF5518 PF17647.1 ORX61618.1 - 0.0067 16.6 0.5 0.0067 16.6 0.5 4.3 5 1 0 6 6 6 1 Family of unknown function (DUF5518) PglZ PF08665.12 ORX61618.1 - 0.059 13.5 0.1 1.2 9.2 0.1 2.2 2 0 0 2 2 2 0 PglZ domain ATPase PF06745.13 ORX61619.1 - 0.0039 16.6 0.3 0.0043 16.4 0.3 1.1 1 0 0 1 1 1 1 KaiC FapA PF03961.13 ORX61619.1 - 0.063 11.9 2.4 0.071 11.7 2.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FAST_2 PF08368.12 ORX61619.1 - 0.069 13.9 1.2 0.13 13.1 0.4 1.7 1 1 1 2 2 2 0 FAST kinase-like protein, subdomain 2 ZapB PF06005.12 ORX61619.1 - 0.12 12.8 5.1 0.22 12.0 5.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB CLZ PF16526.5 ORX61619.1 - 0.93 9.9 6.3 1.7 9.1 2.1 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Methyltransf_3 PF01596.17 ORX61620.1 - 3.4e-42 144.0 0.0 4.3e-42 143.7 0.0 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ORX61620.1 - 9.8e-14 52.3 0.0 9.8e-13 49.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX61620.1 - 3.1e-08 33.6 0.0 4.4e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ORX61620.1 - 9.1e-08 32.1 0.0 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 ORX61620.1 - 7.6e-06 26.6 0.0 3.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_15 PF09445.10 ORX61620.1 - 0.00038 20.1 0.0 0.00059 19.4 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Cons_hypoth95 PF03602.15 ORX61620.1 - 0.00062 19.5 0.0 0.002 17.8 0.0 1.8 1 1 1 2 2 2 1 Conserved hypothetical protein 95 Methyltransf_11 PF08241.12 ORX61620.1 - 0.0052 17.4 0.0 0.022 15.4 0.0 2.0 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX61620.1 - 0.014 14.8 0.0 0.026 13.8 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_16 PF10294.9 ORX61620.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase FAD_binding_2 PF00890.24 ORX61621.1 - 5.9e-43 147.5 0.7 3.7e-42 144.9 0.7 1.9 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ORX61621.1 - 8.9e-09 35.0 0.1 6.9e-05 22.2 0.0 2.6 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX61621.1 - 7.5e-08 32.3 3.6 7.5e-08 32.3 3.6 2.4 3 1 0 3 3 3 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ORX61621.1 - 2.2e-07 30.6 1.0 6.5e-07 29.1 0.8 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX61621.1 - 6.3e-06 25.1 3.5 1.2e-05 24.2 0.6 2.4 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ORX61621.1 - 1.2e-05 24.6 0.9 2.3e-05 23.7 0.9 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ORX61621.1 - 8.1e-05 22.0 0.2 0.00012 21.4 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ORX61621.1 - 0.00047 20.3 0.5 0.00047 20.3 0.5 2.9 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX61621.1 - 0.0048 16.2 0.1 0.05 12.8 0.1 2.1 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 ORX61621.1 - 0.0057 15.9 0.0 0.0092 15.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ORX61621.1 - 0.0064 17.0 0.4 0.23 12.1 0.4 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ORX61621.1 - 0.065 12.1 0.2 0.097 11.5 0.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Lycopene_cycl PF05834.12 ORX61621.1 - 0.09 11.8 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 ORX61621.1 - 0.1 11.8 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MFS_1 PF07690.16 ORX61622.1 - 3.8e-20 72.1 22.4 3.9e-10 39.2 12.8 2.3 1 1 1 2 2 2 2 Major Facilitator Superfamily Med7 PF05983.11 ORX61623.1 - 5.7e-38 130.9 16.5 4.4e-28 98.7 3.3 2.0 1 1 1 2 2 2 2 MED7 protein DNA_pol_A_exo1 PF01612.20 ORX61624.1 - 1.9e-10 40.8 0.0 4.8e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 3'-5' exonuclease HMG_box_2 PF09011.10 ORX61624.1 - 0.011 16.3 1.3 2.3 8.8 0.7 3.8 4 0 0 4 4 4 0 HMG-box domain Methyltransf_25 PF13649.6 ORX61625.1 - 4.4e-14 53.0 0.0 1.1e-13 51.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX61625.1 - 4.9e-12 46.3 0.0 9.1e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX61625.1 - 9.5e-09 35.2 0.1 3.8e-08 33.3 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX61625.1 - 9.7e-08 32.0 0.0 1.5e-07 31.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX61625.1 - 7.1e-07 28.8 0.0 1.8e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ORX61625.1 - 4.4e-06 27.4 0.0 2.4e-05 25.0 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX61625.1 - 4.9e-05 22.9 0.0 0.00013 21.5 0.0 1.8 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 ORX61625.1 - 0.0037 16.6 0.0 0.0048 16.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_8 PF05148.15 ORX61625.1 - 0.0049 16.7 0.0 0.0061 16.4 0.0 1.2 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_29 PF03141.16 ORX61625.1 - 0.022 13.4 0.0 0.05 12.2 0.0 1.6 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Neprosin_AP PF14365.6 ORX61625.1 - 0.056 13.9 0.3 0.088 13.3 0.3 1.2 1 0 0 1 1 1 0 Neprosin activation peptide WD40 PF00400.32 ORX61626.1 - 1e-14 54.6 0.0 0.0086 16.9 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61626.1 - 8.7e-07 29.2 0.0 1.1 9.7 0.0 4.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX61626.1 - 9e-05 21.6 0.0 0.0028 16.7 0.0 2.3 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ORX61626.1 - 0.0026 17.1 0.0 0.0073 15.7 0.0 1.7 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ORX61626.1 - 0.021 14.1 0.3 0.078 12.3 0.1 2.0 2 1 1 3 3 3 0 WD40-like domain Dicty_CAD PF05720.12 ORX61626.1 - 0.084 12.9 0.0 14 5.7 0.0 2.7 2 0 0 2 2 2 0 Cell-cell adhesion domain DUF1563 PF07599.11 ORX61626.1 - 0.12 12.5 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) tRNA-synt_1_2 PF13603.6 ORX61627.1 - 6.5e-56 188.8 0.1 1e-55 188.1 0.1 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1 PF00133.22 ORX61627.1 - 2.2e-54 184.7 0.6 1.5e-16 59.8 0.0 6.0 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ORX61627.1 - 4.8e-20 71.7 2.4 6.7e-14 51.4 0.0 4.6 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ORX61627.1 - 3e-13 50.0 0.0 6.5e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Ribosomal_L44 PF00935.19 ORX61629.1 - 3.5e-38 129.9 11.1 5e-38 129.4 11.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 PET117 PF15786.5 ORX61630.1 - 3.6e-23 81.6 0.7 4.3e-23 81.4 0.7 1.1 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial DUF3915 PF13054.6 ORX61630.1 - 0.13 12.3 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Ribosomal_S27 PF01599.19 ORX61631.1 - 7.7e-27 93.2 1.5 7.7e-27 93.2 1.5 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a ubiquitin PF00240.23 ORX61631.1 - 3.2e-12 46.0 0.0 6.1e-12 45.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family IBR PF01485.21 ORX61631.1 - 0.038 14.2 0.2 0.073 13.3 0.2 1.5 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Rad60-SLD PF11976.8 ORX61631.1 - 0.086 12.7 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like CRC_subunit PF08624.10 ORX61632.1 - 2.9e-41 141.0 0.1 6e-41 140.0 0.1 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit UQ_con PF00179.26 ORX61633.1 - 4.1e-49 165.8 0.0 4.5e-49 165.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Peptidase_S9 PF00326.21 ORX61634.1 - 2.5e-48 164.3 0.0 4.1e-48 163.7 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S9_N PF02897.15 ORX61634.1 - 1.2e-46 159.4 0.5 1.5e-46 159.0 0.5 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S15 PF02129.18 ORX61634.1 - 4.1e-07 29.9 0.0 3.6e-05 23.5 0.0 2.3 1 1 1 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 ORX61634.1 - 0.0014 18.3 0.0 0.004 16.8 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX61634.1 - 0.0017 17.7 0.0 0.0028 16.9 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ORX61634.1 - 0.011 15.6 0.0 0.035 14.0 0.0 1.7 2 0 0 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.20 ORX61634.1 - 0.083 12.5 0.4 0.2 11.3 0.0 1.8 2 0 0 2 2 2 0 Putative esterase Peptidase_S9_N PF02897.15 ORX61635.1 - 6.3e-09 35.1 0.1 7.7e-09 34.8 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain tRNA-synt_1 PF00133.22 ORX61636.1 - 8e-225 747.7 0.0 1.3e-224 746.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ORX61636.1 - 4e-27 95.0 0.1 1.4e-26 93.3 0.0 1.9 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ORX61636.1 - 9.5e-14 50.9 1.4 1.7e-06 27.1 0.1 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ORX61636.1 - 0.00095 18.6 0.0 0.0023 17.4 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Mito_carr PF00153.27 ORX61637.1 - 1.9e-63 210.4 3.8 1.4e-21 76.2 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ORX61637.1 - 0.0038 17.6 2.6 0.88 10.0 0.1 2.6 2 0 0 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family Peptidase_C97 PF05903.14 ORX61638.1 - 3.1e-33 114.7 0.0 3.7e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 ORX61638.1 - 0.13 12.5 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Pkinase PF00069.25 ORX61640.1 - 1.2e-22 80.6 0.0 1.4e-22 80.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ORX61640.1 - 5.9e-10 38.5 0.0 7.8e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ORX61640.1 - 1.2e-08 34.6 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ORX61640.1 - 0.003 17.5 0.3 0.23 11.4 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family DASH_Spc19 PF08287.11 ORX61641.1 - 3.2e-11 43.4 17.6 3.2e-11 43.4 17.6 2.5 1 1 1 2 2 2 1 Spc19 Strep_SA_rep PF06696.11 ORX61641.1 - 0.0061 16.5 1.3 0.0061 16.5 1.3 2.3 2 0 0 2 2 2 1 Streptococcal surface antigen repeat FapA PF03961.13 ORX61641.1 - 0.066 11.8 8.2 0.11 11.1 8.2 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Myb_DNA-bind_4 PF13837.6 ORX61641.1 - 0.099 13.0 3.4 0.35 11.3 0.1 2.5 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain DUF4337 PF14235.6 ORX61641.1 - 3.3 7.8 14.7 14 5.8 14.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) TMPIT PF07851.13 ORX61641.1 - 9.9 5.3 8.7 22 4.2 8.7 1.6 1 0 0 1 1 1 0 TMPIT-like protein Suppressor_APC PF11414.8 ORX61642.1 - 0.11 12.6 0.1 0.26 11.4 0.1 1.6 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein CCDC-167 PF15188.6 ORX61642.1 - 0.16 12.3 0.7 0.4 11.1 0.7 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 WD40 PF00400.32 ORX61643.1 - 0.00024 21.8 0.3 0.0051 17.6 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61643.1 - 0.0012 19.1 0.1 2.8 8.3 0.0 3.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ORX61643.1 - 0.0073 15.9 0.0 0.014 15.0 0.0 1.4 2 0 0 2 2 2 1 PQQ-like domain KH_1 PF00013.29 ORX61644.1 - 8.8e-42 140.8 6.1 7.1e-16 57.8 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 ORX61644.1 - 2.2e-09 37.0 5.6 0.11 12.4 0.2 4.0 3 1 1 4 4 4 3 KH domain KH_4 PF13083.6 ORX61644.1 - 1.6e-08 34.3 0.3 0.067 13.1 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 ORX61644.1 - 9.6e-05 22.4 3.0 0.082 13.0 0.1 3.3 3 0 0 3 3 3 2 NusA-like KH domain Ank_2 PF12796.7 ORX61645.1 - 5.9e-16 58.8 0.5 3.5e-09 37.1 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX61645.1 - 1.1e-15 57.4 0.8 1.3e-07 31.8 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX61645.1 - 2.7e-15 56.5 0.1 1.1e-06 29.1 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX61645.1 - 6.2e-14 50.7 0.4 1.7e-06 27.9 0.0 3.2 2 1 1 3 3 3 2 Ankyrin repeat Ank PF00023.30 ORX61645.1 - 3.5e-12 46.2 0.5 3.3e-06 27.3 0.1 2.7 2 1 0 2 2 2 2 Ankyrin repeat Phage_TAC_1 PF06222.11 ORX61645.1 - 0.026 14.3 0.6 0.056 13.2 0.4 1.6 1 1 1 2 2 2 0 Phage tail assembly chaperone Anemone_cytotox PF06369.12 ORX61645.1 - 0.055 13.1 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Sea anemone cytotoxic protein SH3_1 PF00018.28 ORX61646.1 - 2.3e-18 65.5 0.1 4e-18 64.7 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX61646.1 - 2.4e-14 52.7 0.1 4.1e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX61646.1 - 2.5e-14 52.8 0.0 4.1e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain VTC PF09359.10 ORX61647.1 - 2.1e-16 60.2 0.0 3.6e-15 56.1 0.0 2.8 1 1 0 1 1 1 1 VTC domain ChaC PF04752.12 ORX61648.1 - 1.1e-67 227.5 0.0 1.3e-67 227.3 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 ORX61648.1 - 0.0021 18.7 1.3 0.0033 18.0 1.3 1.4 1 1 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF4038 PF13204.6 ORX61648.1 - 0.006 16.3 0.0 0.0086 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4038) Zip PF02535.22 ORX61649.1 - 9.5e-60 202.6 3.4 1.1e-59 202.4 3.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter YdjM PF04307.14 ORX61649.1 - 0.0048 16.2 1.4 0.0073 15.6 1.0 1.7 1 1 0 1 1 1 1 LexA-binding, inner membrane-associated putative hydrolase SWIRM-assoc_2 PF16496.5 ORX61650.1 - 4.8e-14 52.1 0.0 5.3e-14 51.9 0.0 1.0 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal SWIRM PF04433.17 ORX61651.1 - 1.9e-17 63.4 0.4 4.7e-17 62.1 0.4 1.7 1 0 0 1 1 1 1 SWIRM domain Myb_DNA-binding PF00249.31 ORX61651.1 - 5.5e-11 42.5 0.1 5.5e-11 42.5 0.1 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM-assoc_1 PF16495.5 ORX61651.1 - 9.1e-11 41.6 1.9 2.2e-10 40.4 1.9 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-bind_6 PF13921.6 ORX61651.1 - 2.2e-07 31.0 0.1 6.8e-07 29.4 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain SDA1 PF05285.12 ORX61651.1 - 0.00017 21.1 10.7 0.00017 21.1 10.7 2.6 3 0 0 3 3 3 2 SDA1 Trypan_PARP PF05887.11 ORX61651.1 - 0.014 15.4 0.8 0.014 15.4 0.8 2.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SANT_DAMP1_like PF16282.5 ORX61651.1 - 0.073 13.3 0.2 0.21 11.8 0.2 1.7 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 tRNA-synt_1 PF00133.22 ORX61652.1 - 1.2e-40 139.4 0.2 5.8e-29 100.8 0.1 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ORX61652.1 - 1.5e-17 63.5 0.0 1.1e-09 37.6 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 ORX61652.1 - 4.4e-08 33.2 0.1 9.4e-08 32.2 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 ORX61652.1 - 1.2e-07 31.4 0.0 2.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF2791 PF10923.8 ORX61652.1 - 0.023 13.5 0.0 0.039 12.8 0.0 1.3 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) L51_S25_CI-B8 PF05047.16 ORX61653.1 - 4e-09 36.2 0.1 6.1e-09 35.7 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Ribonuc_red_lgC PF02867.15 ORX61655.1 - 3.8e-20 71.9 0.0 4.3e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain GET2 PF08690.10 ORX61656.1 - 1.1e-11 45.0 1.0 1.6e-08 34.6 0.1 2.0 2 0 0 2 2 2 2 GET complex subunit GET2 PAS PF00989.25 ORX61657.1 - 0.0008 19.4 0.0 0.55 10.3 0.0 2.4 2 0 0 2 2 2 2 PAS fold PAS_3 PF08447.12 ORX61657.1 - 0.005 17.1 0.0 0.14 12.4 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 ORX61657.1 - 0.064 13.5 0.0 0.76 10.1 0.0 2.3 2 0 0 2 2 2 0 PAS fold PAS_9 PF13426.7 ORX61657.1 - 0.13 12.5 0.0 2.8 8.2 0.0 2.2 2 0 0 2 2 2 0 PAS domain tRNA_bind PF01588.20 ORX61658.1 - 5.1e-29 100.2 0.0 1e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain GST_C_3 PF14497.6 ORX61658.1 - 8.4e-06 25.9 0.1 8.4e-06 25.9 0.1 2.3 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX61658.1 - 0.0001 22.4 0.0 0.0001 22.4 0.0 2.9 2 1 0 2 2 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX61658.1 - 0.0022 18.0 0.0 0.0046 17.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain IHABP4_N PF16174.5 ORX61658.1 - 0.0026 18.4 11.3 0.0041 17.7 11.3 1.2 1 0 0 1 1 1 1 Intracellular hyaluronan-binding protein 4 N-terminal RNA_pol_Rpc4 PF05132.14 ORX61658.1 - 0.0056 17.1 5.8 0.0098 16.3 5.8 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 NARP1 PF12569.8 ORX61658.1 - 0.0066 15.4 10.2 0.01 14.8 10.2 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 Rtf2 PF04641.12 ORX61658.1 - 0.013 14.8 9.6 0.023 14.1 9.6 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger SpoIIIAH PF12685.7 ORX61658.1 - 0.014 15.3 5.0 0.021 14.6 5.0 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Glutaredoxin2_C PF04399.13 ORX61658.1 - 0.035 13.9 0.0 0.074 12.9 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain CPSF100_C PF13299.6 ORX61658.1 - 0.036 14.3 2.1 0.065 13.4 2.1 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4702 PF15774.5 ORX61658.1 - 0.073 12.0 2.6 0.11 11.5 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4702) DUF913 PF06025.12 ORX61658.1 - 0.13 11.2 1.4 0.18 10.8 1.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GST_C_6 PF17171.4 ORX61658.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain CENP-N PF05238.13 ORX61658.1 - 0.24 10.7 4.9 0.36 10.1 4.9 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like FancD2 PF14631.6 ORX61658.1 - 0.29 8.5 4.0 0.36 8.2 4.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Presenilin PF01080.17 ORX61658.1 - 0.74 8.5 3.3 1.1 8.0 3.3 1.1 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 ORX61658.1 - 1 9.1 9.0 2.1 8.1 9.0 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RR_TM4-6 PF06459.12 ORX61658.1 - 1.1 9.0 12.6 2.1 8.1 12.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ORX61658.1 - 2.4 6.3 9.0 3.4 5.8 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ORX61658.1 - 2.8 6.6 7.8 4.4 6.0 7.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TIMELESS_C PF05029.13 ORX61659.1 - 0.037 13.2 4.9 0.05 12.8 4.9 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region Ras PF00071.22 ORX61660.1 - 9.6e-61 204.1 0.2 1.1e-60 203.9 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX61660.1 - 7e-21 74.7 0.0 1.2e-20 74.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX61660.1 - 2.4e-08 33.6 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ORX61660.1 - 3.8e-05 23.3 0.0 5.2e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ORX61660.1 - 7e-05 22.8 0.0 0.14 12.0 0.0 2.3 2 1 0 2 2 2 2 RsgA GTPase MMR_HSR1_Xtn PF16897.5 ORX61660.1 - 0.002 18.1 0.0 0.0041 17.1 0.0 1.5 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 ORX61660.1 - 0.011 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 ORX61660.1 - 0.019 14.2 0.2 1.5 7.9 0.1 2.1 1 1 1 2 2 2 0 G-protein alpha subunit CTP_transf_3 PF02348.19 ORX61660.1 - 0.033 14.1 0.2 0.44 10.4 0.0 2.0 1 1 1 2 2 2 0 Cytidylyltransferase FeoB_N PF02421.18 ORX61660.1 - 0.041 13.4 0.1 0.098 12.2 0.1 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Pkinase PF00069.25 ORX61661.1 - 2e-60 204.4 0.0 2.3e-60 204.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61661.1 - 8.2e-41 140.0 0.0 1.1e-40 139.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61661.1 - 1.9e-05 24.1 0.0 2.6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX61661.1 - 0.0064 15.3 0.0 0.008 15.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ORX61661.1 - 0.054 12.4 0.1 0.084 11.8 0.1 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Ras PF00071.22 ORX61662.1 - 1.3e-57 194.0 0.2 1.6e-57 193.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX61662.1 - 2.9e-37 127.5 0.1 6.1e-37 126.5 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX61662.1 - 3.1e-17 62.6 0.0 4.1e-17 62.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX61662.1 - 4.4e-06 26.7 0.0 0.0066 16.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gtr1_RagA PF04670.12 ORX61662.1 - 8.6e-06 25.3 0.1 1.2e-05 24.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX61662.1 - 1.3e-05 25.2 0.0 3.1e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ORX61662.1 - 1.8e-05 24.3 0.0 4.2e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ORX61662.1 - 5.6e-05 22.8 0.0 0.00096 18.7 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ORX61662.1 - 0.031 13.8 0.0 3.2 7.2 0.0 2.3 2 0 0 2 2 2 0 Ferrous iron transport protein B TetR_C_16 PF17920.1 ORX61662.1 - 0.034 14.4 0.0 0.079 13.2 0.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain AAA_7 PF12775.7 ORX61662.1 - 0.068 12.7 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Tom5 PF10642.9 ORX61663.1 - 3.9e-16 58.8 1.7 4.3e-16 58.7 1.7 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase TPR_1 PF00515.28 ORX61664.1 - 3.5e-26 89.9 0.8 1.7e-08 33.9 0.1 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61664.1 - 1e-23 81.5 0.2 2.1e-06 27.4 0.2 5.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX61664.1 - 7.1e-22 76.8 1.4 6.7e-07 28.9 0.0 5.1 3 1 2 5 5 5 4 TPR repeat TPR_16 PF13432.6 ORX61664.1 - 2.1e-19 69.9 7.5 2.2e-07 31.4 0.1 5.1 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ORX61664.1 - 5.9e-17 60.4 0.1 0.00021 21.2 0.0 5.4 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX61664.1 - 2.3e-15 55.8 2.8 0.00027 21.1 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ORX61664.1 - 1.1e-12 47.6 15.2 6.3e-05 23.5 0.1 6.2 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX61664.1 - 7.4e-12 45.6 2.4 0.0068 16.9 0.0 4.6 2 2 1 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX61664.1 - 4.3e-10 39.7 4.2 0.0041 17.4 0.9 5.4 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ORX61664.1 - 3.2e-08 33.8 7.4 0.032 14.6 0.1 5.4 3 2 3 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ORX61664.1 - 1.1e-07 31.3 3.0 0.1 12.7 0.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX61664.1 - 2.1e-06 27.9 0.8 0.00043 20.5 0.1 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ORX61664.1 - 1.2e-05 25.4 3.8 0.066 13.4 0.0 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX61664.1 - 2e-05 24.9 0.5 18 6.3 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_15 PF13429.6 ORX61664.1 - 0.00035 19.9 0.5 0.19 10.9 0.4 2.5 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 ORX61664.1 - 0.012 15.6 0.0 5 7.2 0.0 3.1 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ORX61664.1 - 0.017 15.0 7.9 0.43 10.5 0.8 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 ORX61664.1 - 0.027 14.5 0.4 4.5 7.4 0.0 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF4248 PF14053.6 ORX61664.1 - 0.09 12.8 0.1 0.28 11.2 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4248) DUF1641 PF07849.11 ORX61664.1 - 0.096 12.6 0.2 0.22 11.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) 4HB_MCP_1 PF12729.7 ORX61664.1 - 2.7 7.5 4.2 8.4 5.9 0.2 3.2 3 1 0 3 3 3 0 Four helix bundle sensory module for signal transduction Aa_trans PF01490.18 ORX61665.1 - 1.4e-67 228.2 29.3 2.6e-56 191.1 19.9 2.0 1 1 1 2 2 2 2 Transmembrane amino acid transporter protein DUF202 PF02656.15 ORX61665.1 - 5.8 7.4 6.8 2.9 8.4 2.0 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF202) Polysacc_deac_1 PF01522.21 ORX61666.1 - 5.6e-30 103.8 0.0 9.3e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 ORX61666.1 - 0.002 17.8 0.3 0.0049 16.6 0.3 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 ORX61666.1 - 0.0066 15.7 0.0 0.0099 15.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 DUF4611 PF15387.6 ORX61666.1 - 0.049 13.8 3.8 1.2 9.4 3.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) GxGYxYP_C PF14323.6 ORX61666.1 - 0.075 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain Defensin_propep PF00879.18 ORX61666.1 - 1.6 9.1 6.3 0.17 12.2 1.5 1.8 2 0 0 2 2 2 0 Defensin propeptide TRAM_LAG1_CLN8 PF03798.16 ORX61667.1 - 1.3e-36 126.2 30.3 1.3e-36 126.2 30.3 1.9 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 ORX61667.1 - 2e-16 59.4 0.4 5.7e-16 57.9 0.4 1.8 1 0 0 1 1 1 1 TRAM1-like protein GCS PF03074.16 ORX61668.1 - 2.5e-179 596.3 0.1 3.2e-179 596.0 0.1 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase Nuc_sug_transp PF04142.15 ORX61669.1 - 6.1e-105 350.9 25.3 2.8e-67 227.1 5.6 2.0 2 0 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 ORX61669.1 - 0.00013 22.2 6.4 0.00013 22.2 6.4 3.2 3 1 0 3 3 3 1 EamA-like transporter family UAA PF08449.11 ORX61669.1 - 0.00016 21.0 18.8 0.00017 20.9 0.6 2.5 2 1 0 2 2 2 2 UAA transporter family Cyt_c_ox_IV PF12270.8 ORX61669.1 - 0.026 14.7 0.0 0.026 14.7 0.0 2.8 3 1 0 2 2 2 0 Cytochrome c oxidase subunit IV PUNUT PF16913.5 ORX61669.1 - 0.57 9.3 19.8 0.03 13.6 1.4 3.3 3 1 0 3 3 3 0 Purine nucleobase transmembrane transport TMEM234 PF10639.9 ORX61669.1 - 0.57 10.2 10.5 0.96 9.5 0.7 2.8 2 1 0 2 2 2 0 Putative transmembrane family 234 DUF4203 PF13886.6 ORX61670.1 - 4.9e-28 98.2 23.7 5.6e-28 98.0 23.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Trp_oprn_chp PF09534.10 ORX61670.1 - 0.039 13.8 0.2 0.039 13.8 0.2 2.1 1 1 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) TMEM132D_C PF15706.5 ORX61670.1 - 0.79 9.5 0.0 0.79 9.5 0.0 2.8 2 1 1 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Zn_clus PF00172.18 ORX61671.1 - 1.3e-05 25.2 10.3 1.3e-05 25.2 10.3 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ORX61671.1 - 4.1e-05 23.5 0.0 7.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 PAS fold ANAPC3 PF12895.7 ORX61672.1 - 4.1e-16 59.0 19.2 9.5e-14 51.4 1.0 4.7 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ORX61672.1 - 7.5e-13 47.5 21.9 0.003 17.5 0.3 8.8 9 2 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX61672.1 - 1e-11 44.1 11.6 0.001 18.8 0.3 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX61672.1 - 3.3e-11 43.3 16.3 0.00012 22.2 0.9 5.9 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ORX61672.1 - 7.2e-11 41.4 6.6 0.019 15.2 0.0 7.7 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX61672.1 - 6.2e-08 33.0 10.4 0.0082 16.6 0.2 6.2 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX61672.1 - 3.5e-06 27.4 13.8 0.042 14.7 0.3 6.5 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX61672.1 - 1.6e-05 24.6 4.7 0.12 12.3 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX61672.1 - 2.1e-05 25.0 9.1 0.0062 17.2 0.1 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX61672.1 - 9.1e-05 22.6 4.8 0.51 10.8 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ORX61672.1 - 0.00011 21.8 0.7 1.2 8.9 0.0 4.5 4 0 0 4 4 4 1 TPR repeat TPR_6 PF13174.6 ORX61672.1 - 0.017 15.7 4.6 6.8 7.6 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 ORX61672.1 - 0.086 12.9 0.0 0.24 11.5 0.0 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ORX61672.1 - 0.16 11.9 0.0 0.39 10.6 0.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TPR_7 PF13176.6 ORX61672.1 - 0.18 11.9 4.9 12 6.2 0.1 4.6 4 0 0 4 4 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX61672.1 - 0.32 11.1 8.6 3 8.0 0.0 4.4 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 ORX61672.1 - 1.6 8.8 9.0 2.3 8.3 0.1 4.0 5 0 0 5 5 5 0 Putative TPR-like repeat zf-like PF04071.12 ORX61673.1 - 0.083 12.8 0.4 0.11 12.4 0.4 1.3 1 0 0 1 1 1 0 Cysteine-rich small domain RNA_pol_Rpb2_2 PF04561.14 ORX61674.1 - 0.019 14.6 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 2 Frag1 PF10277.9 ORX61677.1 - 1.1e-40 139.5 8.6 1.3e-40 139.3 8.6 1.1 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Peptidase_U4 PF03419.13 ORX61677.1 - 0.046 13.0 0.1 0.046 13.0 0.1 1.8 2 1 0 2 2 2 0 Sporulation factor SpoIIGA DUF2568 PF10823.8 ORX61677.1 - 0.071 13.4 2.1 0.2 12.0 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2568) AAA PF00004.29 ORX61678.1 - 1.9e-37 128.7 0.0 2.9e-37 128.1 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX61678.1 - 1.5e-12 47.1 0.0 3.4e-12 45.9 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ORX61678.1 - 3.6e-06 27.5 0.1 0.00032 21.1 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ORX61678.1 - 4.6e-06 26.5 0.0 1.8e-05 24.6 0.0 1.9 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX61678.1 - 1.8e-05 24.7 0.1 0.00011 22.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ORX61678.1 - 4.4e-05 23.5 0.0 9.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ORX61678.1 - 4.8e-05 23.5 0.0 0.00012 22.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX61678.1 - 7.5e-05 23.0 0.2 0.015 15.6 0.0 3.0 1 1 2 3 3 3 1 AAA domain AAA_18 PF13238.6 ORX61678.1 - 0.00019 21.9 0.0 0.00035 21.1 0.0 1.6 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 ORX61678.1 - 0.0002 20.8 0.0 0.58 9.5 0.0 2.8 2 1 1 3 3 3 2 Bacterial TniB protein RNA_helicase PF00910.22 ORX61678.1 - 0.00067 20.0 0.0 0.0014 18.9 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 ORX61678.1 - 0.0009 18.7 0.3 0.0024 17.3 0.2 1.6 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 ORX61678.1 - 0.0011 18.9 0.1 0.0088 16.0 0.0 2.3 2 1 0 2 2 2 1 Rad17 P-loop domain AAA_33 PF13671.6 ORX61678.1 - 0.0014 18.8 0.0 0.0025 18.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ORX61678.1 - 0.0021 17.3 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ORX61678.1 - 0.0035 16.9 0.4 0.012 15.1 0.1 2.1 2 1 0 2 2 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ORX61678.1 - 0.0039 16.9 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ORX61678.1 - 0.0064 16.2 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Guanylate_kin PF00625.21 ORX61678.1 - 0.0066 16.2 0.0 0.064 12.9 0.0 2.5 2 1 0 3 3 3 1 Guanylate kinase TIP49 PF06068.13 ORX61678.1 - 0.0094 15.2 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_25 PF13481.6 ORX61678.1 - 0.01 15.4 0.2 0.087 12.4 0.1 2.1 1 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ORX61678.1 - 0.012 15.8 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase PF06745.13 ORX61678.1 - 0.014 14.8 0.0 0.074 12.4 0.0 1.9 1 1 1 2 2 2 0 KaiC AAA_28 PF13521.6 ORX61678.1 - 0.015 15.6 0.0 0.029 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX61678.1 - 0.021 14.7 0.0 0.054 13.4 0.0 1.7 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 ORX61678.1 - 0.024 14.4 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_17 PF13207.6 ORX61678.1 - 0.026 15.0 0.1 0.073 13.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 ORX61678.1 - 0.031 14.1 0.0 0.084 12.7 0.0 1.7 2 0 0 2 2 1 0 Chloramphenicol phosphotransferase-like protein Parvo_NS1 PF01057.17 ORX61678.1 - 0.036 13.2 0.0 0.056 12.5 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 KAP_NTPase PF07693.14 ORX61678.1 - 0.038 13.2 0.1 0.57 9.4 0.0 2.1 1 1 1 2 2 2 0 KAP family P-loop domain ABC_tran PF00005.27 ORX61678.1 - 0.043 14.3 0.0 0.11 13.0 0.0 1.7 1 1 0 1 1 1 0 ABC transporter ATPase_2 PF01637.18 ORX61678.1 - 0.061 13.2 0.0 0.37 10.7 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ORX61678.1 - 0.073 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 ORX61678.1 - 0.078 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ORX61678.1 - 0.083 12.2 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Glyco_hydro_38N PF01074.22 ORX61679.1 - 1.7e-85 286.9 0.1 3.6e-85 285.8 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 ORX61679.1 - 4.3e-57 193.6 0.0 6.9e-57 193.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ORX61679.1 - 5.1e-21 74.6 0.0 1.2e-20 73.5 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 ORX61679.1 - 4.6e-13 49.1 0.0 1.8e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_57 PF03065.15 ORX61679.1 - 0.002 17.4 0.0 0.0038 16.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Pribosyl_synth PF14572.6 ORX61680.1 - 8.8e-41 140.0 2.6 5.3e-34 117.9 0.9 2.3 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 ORX61680.1 - 2.6e-37 127.3 0.0 2.7e-35 120.8 0.0 2.6 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 ORX61680.1 - 8.5e-13 48.1 0.1 1.3e-12 47.5 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ORX61680.1 - 0.042 13.3 0.1 0.075 12.5 0.1 1.4 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Ala_racemase_C PF00842.21 ORX61680.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Alanine racemase, C-terminal domain SCP2 PF02036.17 ORX61681.1 - 4.4e-22 78.5 1.0 5.4e-22 78.2 1.0 1.1 1 0 0 1 1 1 1 SCP-2 sterol transfer family ArlS_N PF18719.1 ORX61681.1 - 0.039 14.2 0.4 0.061 13.5 0.4 1.4 1 0 0 1 1 1 0 ArlS sensor domain GATase_7 PF13537.6 ORX61681.1 - 0.067 13.1 0.0 0.15 12.0 0.0 1.5 1 1 1 2 2 2 0 Glutamine amidotransferase domain UFC1 PF08694.11 ORX61681.1 - 0.069 12.8 0.0 0.079 12.6 0.0 1.3 1 1 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 NAGLU_N PF12971.7 ORX61681.1 - 0.075 12.8 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain CAP_GLY PF01302.25 ORX61682.1 - 1.3e-22 79.5 0.5 2e-22 78.9 0.5 1.3 1 0 0 1 1 1 1 CAP-Gly domain HMA PF00403.26 ORX61684.1 - 1.4e-15 57.5 1.2 1.5e-15 57.4 1.2 1.0 1 0 0 1 1 1 1 Heavy-metal-associated domain Adaptin_binding PF10199.9 ORX61685.1 - 2e-08 34.8 3.6 5.4e-08 33.5 3.6 1.8 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Exo_endo_phos PF03372.23 ORX61686.1 - 1.5e-18 67.1 0.0 3.2e-18 66.1 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Histone PF00125.24 ORX61686.1 - 0.03 14.7 0.5 0.046 14.1 0.5 1.3 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 OSR1_C PF12202.8 ORX61687.1 - 0.031 14.5 0.5 0.072 13.3 0.1 1.8 2 1 0 2 2 2 0 Oxidative-stress-responsive kinase 1 C-terminal domain Hexokinase_2 PF03727.16 ORX61688.1 - 4.3e-68 229.3 0.0 5.6e-68 229.0 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 ORX61688.1 - 9.2e-61 205.2 0.1 1.4e-60 204.6 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Glucosamine_iso PF01182.20 ORX61689.1 - 5.5e-21 75.5 0.0 8.1e-21 74.9 0.0 1.2 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Pox_ser-thr_kin PF05445.11 ORX61689.1 - 0.11 11.4 0.2 0.31 10.0 0.1 1.7 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase PhoLip_ATPase_C PF16212.5 ORX61690.1 - 6e-59 199.8 28.0 1.6e-43 149.3 16.9 3.5 3 1 1 4 4 4 2 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ORX61690.1 - 5e-23 80.6 3.9 5e-23 80.6 3.9 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 ORX61690.1 - 1.1e-12 47.9 0.0 6.4e-12 45.4 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ORX61690.1 - 3.6e-11 43.8 1.7 5.5e-06 26.8 0.4 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ORX61690.1 - 3.2e-08 33.3 0.0 9.8e-08 31.7 0.0 1.9 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ORX61690.1 - 0.0012 18.7 0.0 0.013 15.3 0.0 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase NAPRTase PF04095.16 ORX61690.1 - 0.011 15.3 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) family HAD PF12710.7 ORX61690.1 - 0.14 12.5 0.0 2.6 8.4 0.1 2.4 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX61690.1 - 0.22 11.6 0.8 0.62 10.1 0.1 2.1 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Glyco_hydro_72 PF03198.14 ORX61692.1 - 5e-45 154.1 0.5 1.3e-44 152.7 0.6 1.6 1 1 1 2 2 2 2 Glucanosyltransferase DUF3091 PF11291.8 ORX61695.1 - 0.039 14.1 0.3 0.18 12.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) Ribonuc_red_lgC PF02867.15 ORX61696.1 - 7.5e-187 622.0 0.0 9e-187 621.8 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ORX61696.1 - 3.8e-23 81.3 0.0 1.5e-22 79.4 0.0 2.0 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain Ly-6_related PF06579.12 ORX61696.1 - 0.099 12.9 0.3 0.22 11.8 0.3 1.5 1 0 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein Sad1_UNC PF07738.13 ORX61698.1 - 1.3e-31 109.4 0.1 1.9e-31 108.8 0.1 1.3 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal DFRP_C PF16543.5 ORX61698.1 - 0.017 15.6 0.1 0.064 13.8 0.0 1.9 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Muskelin_N PF06588.11 ORX61698.1 - 0.059 13.3 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Muskelin N-terminus Apolipoprotein PF01442.18 ORX61698.1 - 0.22 11.4 6.7 0.59 10.0 6.7 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain THOC7 PF05615.13 ORX61698.1 - 8.1 6.7 9.8 7.7 6.8 0.1 2.5 2 0 0 2 2 2 0 Tho complex subunit 7 CDC45 PF02724.14 ORX61699.1 - 0.043 12.1 0.2 0.047 12.0 0.2 1.0 1 0 0 1 1 1 0 CDC45-like protein CK_II_beta PF01214.18 ORX61700.1 - 1.8e-70 236.5 0.2 2e-70 236.3 0.2 1.0 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Snapin_Pallidin PF14712.6 ORX61702.1 - 7.5e-05 23.1 4.2 7.5e-05 23.1 4.2 1.6 2 0 0 2 2 2 1 Snapin/Pallidin Syntaxin PF00804.25 ORX61703.1 - 2.3e-36 125.4 15.0 3.5e-36 124.8 15.0 1.3 1 0 0 1 1 1 1 Syntaxin SNARE PF05739.19 ORX61703.1 - 6.3e-12 45.3 0.2 1.5e-11 44.1 0.2 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 ORX61703.1 - 3.1e-09 37.1 2.1 3.1e-09 37.1 2.1 2.4 2 1 0 2 2 2 1 Syntaxin-like protein SKA1 PF07160.12 ORX61703.1 - 0.013 15.4 2.4 0.013 15.4 2.4 2.4 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Bap31_Bap29_C PF18035.1 ORX61703.1 - 0.018 15.0 0.3 3 7.9 0.1 2.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF386 PF04074.12 ORX61703.1 - 0.13 12.1 2.5 0.37 10.7 2.5 1.9 1 1 0 1 1 1 0 YhcH/YjgK/YiaL Neur_chan_memb PF02932.16 ORX61703.1 - 0.68 9.9 6.3 0.17 11.9 2.1 1.8 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF4790 PF16037.5 ORX61703.1 - 0.74 10.3 9.1 0.15 12.5 0.6 3.1 4 0 0 4 4 3 0 Domain of unknown function (DUF4790) Vac_Fusion PF02346.16 ORX61703.1 - 0.95 9.1 8.0 0.076 12.6 1.1 2.6 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 TACC_C PF05010.14 ORX61703.1 - 1.3 8.8 16.3 4 7.2 3.6 2.4 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4988 PF16378.5 ORX61703.1 - 1.6 8.3 5.1 3.7 7.2 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF2873 PF11395.8 ORX61703.1 - 3.2 7.7 6.2 6.7 6.7 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2873) DUF745 PF05335.13 ORX61703.1 - 5.1 6.8 13.8 0.32 10.7 6.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF745) MCU PF04678.13 ORX61703.1 - 5.7 7.0 12.2 86 3.2 12.1 2.4 1 1 0 1 1 1 0 Mitochondrial calcium uniporter SUI1 PF01253.22 ORX61704.1 - 2.2e-22 79.4 0.1 5.3e-22 78.1 0.1 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 BAR_2 PF10455.9 ORX61704.1 - 0.00061 19.0 2.6 0.00076 18.7 2.6 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking G-patch PF01585.23 ORX61705.1 - 1.7e-15 56.6 1.8 3e-15 55.8 1.8 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ORX61705.1 - 7.8e-06 25.9 0.5 7.8e-06 25.9 0.5 2.8 3 0 0 3 3 3 1 G-patch domain zf-met PF12874.7 ORX61705.1 - 4.8e-05 23.6 0.5 8.9e-05 22.8 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX61705.1 - 0.00012 22.2 3.9 0.00012 22.2 3.9 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-DBF PF07535.12 ORX61705.1 - 0.019 15.1 4.1 0.019 15.1 4.1 1.9 2 0 0 2 2 2 0 DBF zinc finger AAA_23 PF13476.6 ORX61705.1 - 0.22 12.0 12.8 0.031 14.8 1.7 2.2 2 0 0 2 2 2 0 AAA domain Presenilin PF01080.17 ORX61705.1 - 0.67 8.7 10.2 0.88 8.3 10.2 1.1 1 0 0 1 1 1 0 Presenilin UPF0172 PF03665.13 ORX61705.1 - 0.75 9.8 6.7 0.36 10.9 4.6 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0172) ALMT PF11744.8 ORX61705.1 - 1.4 7.7 9.6 1.8 7.3 9.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_11 PF13086.6 ORX61705.1 - 3.2 7.5 11.6 5.4 6.7 11.6 1.3 1 0 0 1 1 1 0 AAA domain WDCP PF15390.6 ORX61705.1 - 4.5 5.5 12.5 5.8 5.2 12.5 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family LIM PF00412.22 ORX61706.1 - 3.4e-37 126.5 39.8 9.5e-13 48.2 3.0 3.8 4 0 0 4 4 4 3 LIM domain zf-FCS PF06467.14 ORX61706.1 - 0.038 13.9 7.5 0.038 13.9 7.5 3.1 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif DUF4795 PF16043.5 ORX61706.1 - 0.85 9.2 2.0 18 4.8 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) DUF2256 PF10013.9 ORX61706.1 - 1.6 8.9 0.0 1.6 8.9 0.0 6.2 7 1 0 7 7 7 0 Uncharacterized protein conserved in bacteria (DUF2256) NTP_transferase PF00483.23 ORX61708.1 - 1.2e-30 106.9 0.0 1.6e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 ORX61708.1 - 1.8e-12 46.5 3.3 5.3e-06 25.9 0.1 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 ORX61708.1 - 2.3e-07 31.3 0.0 3.9e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain DUF4954 PF16314.5 ORX61708.1 - 0.00013 20.3 0.1 0.00041 18.6 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4954) Ntox30 PF15532.6 ORX61708.1 - 0.063 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 30 Fucokinase PF07959.12 ORX61708.1 - 0.073 12.0 0.1 0.72 8.7 0.0 2.1 2 0 0 2 2 2 0 L-fucokinase PDZ_5 PF17817.1 ORX61709.1 - 0.012 15.9 0.4 0.033 14.5 0.0 1.9 2 0 0 2 2 2 0 PDZ domain Tmemb_cc2 PF10267.9 ORX61709.1 - 1.5 7.8 5.4 3 6.9 5.4 1.4 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PBP PF01161.20 ORX61710.1 - 6.6e-17 62.1 0.8 1.3e-16 61.1 0.8 1.5 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Stap_Strp_toxin PF01123.20 ORX61710.1 - 0.0056 17.5 0.0 0.016 16.0 0.0 1.8 1 0 0 1 1 1 1 Staphylococcal/Streptococcal toxin, OB-fold domain Beta-lactamase PF00144.24 ORX61712.1 - 3e-41 141.7 3.3 4.3e-41 141.2 3.3 1.2 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ORX61712.1 - 0.0016 18.0 0.7 1.1 8.6 0.1 2.2 2 0 0 2 2 2 2 D-alanyl-D-alanine carboxypeptidase zf-XS PF03470.14 ORX61712.1 - 0.11 12.8 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 XS zinc finger domain Ribosomal_S6e PF01092.19 ORX61717.1 - 1.7e-61 205.7 1.2 3.9e-61 204.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e IF4E PF01652.18 ORX61718.1 - 2.1e-51 173.9 1.1 2.5e-51 173.6 1.1 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF3823_C PF18003.1 ORX61718.1 - 0.032 15.0 0.2 0.28 11.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3823_C) Ribosomal_S7e PF01251.18 ORX61719.1 - 1.3e-83 279.3 1.5 1.5e-83 279.1 1.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Fungal_trans PF04082.18 ORX61720.1 - 4.3e-13 48.9 4.4 1e-12 47.7 4.4 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX61720.1 - 0.0099 16.0 8.0 0.017 15.2 8.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MFS_1 PF07690.16 ORX61721.1 - 8.1e-25 87.5 30.7 8.1e-25 87.5 30.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX61721.1 - 4.6e-05 22.5 13.2 4.6e-05 22.5 13.2 2.9 1 1 0 2 2 2 1 Sugar (and other) transporter YrhK PF14145.6 ORX61721.1 - 0.066 13.1 6.0 0.23 11.3 0.9 3.4 2 0 0 2 2 2 0 YrhK-like protein RhoGAP PF00620.27 ORX61722.1 - 3.5e-29 101.6 0.2 1.4e-28 99.7 0.1 1.9 2 0 0 2 2 2 1 RhoGAP domain CRAL_TRIO_2 PF13716.6 ORX61722.1 - 1.1e-21 77.5 0.2 1.9e-21 76.6 0.2 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 ORX61722.1 - 0.00057 19.6 0.0 0.013 15.2 0.0 2.5 2 0 0 2 2 2 1 CRAL/TRIO domain C2 PF00168.30 ORX61723.1 - 3.5e-71 236.0 4.1 1.3e-15 57.5 0.0 5.8 6 0 0 6 6 6 5 C2 domain Arm-DNA-bind_5 PF17293.2 ORX61723.1 - 0.13 12.7 0.1 0.43 11.1 0.1 1.9 1 0 0 1 1 1 0 Arm DNA-binding domain TMEM154 PF15102.6 ORX61724.1 - 0.056 13.3 0.3 0.06 13.3 0.3 1.0 1 0 0 1 1 1 0 TMEM154 protein family DAHP_synth_1 PF00793.20 ORX61725.1 - 1.6e-101 338.8 0.0 1.9e-101 338.6 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family CMS1 PF14617.6 ORX61726.1 - 3e-38 131.6 0.1 3.8e-38 131.3 0.1 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 ORX61726.1 - 7.6e-07 29.1 0.0 9.1e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase GEN1_C PF18380.1 ORX61726.1 - 0.037 14.9 2.8 0.084 13.8 2.8 1.6 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain YL1 PF05764.13 ORX61726.1 - 0.062 13.4 4.0 0.079 13.1 4.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Guanylate_kin PF00625.21 ORX61727.1 - 7.4e-67 224.6 0.0 8.2e-67 224.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 ORX61727.1 - 2.3e-06 28.2 0.0 3.6e-06 27.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX61727.1 - 8.4e-06 26.0 0.0 0.00013 22.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX61727.1 - 0.0002 21.8 0.5 0.0011 19.4 0.5 2.0 1 1 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ORX61727.1 - 0.00023 21.7 0.1 0.00026 21.5 0.1 1.6 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ORX61727.1 - 0.00035 20.5 0.2 0.00076 19.4 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ORX61727.1 - 0.00054 20.2 0.0 0.0011 19.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ORX61727.1 - 0.00063 19.7 0.2 0.0024 17.8 0.2 1.8 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 ORX61727.1 - 0.00088 19.0 0.2 0.0018 17.9 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ORX61727.1 - 0.0037 17.3 0.1 0.0055 16.8 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF2075 PF09848.9 ORX61727.1 - 0.0061 15.9 0.1 1.3 8.2 0.0 2.1 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 ORX61727.1 - 0.0066 15.5 0.0 0.01 14.9 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein cobW PF02492.19 ORX61727.1 - 0.0074 15.9 0.7 0.055 13.1 0.1 2.3 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 ORX61727.1 - 0.012 15.9 0.1 0.033 14.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX61727.1 - 0.016 15.0 0.2 0.066 12.9 0.2 2.0 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 ORX61727.1 - 0.02 14.8 0.0 0.029 14.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_14 PF13173.6 ORX61727.1 - 0.02 14.9 0.0 0.042 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 ORX61727.1 - 0.023 14.6 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_23 PF13476.6 ORX61727.1 - 0.027 15.0 3.4 0.067 13.7 3.4 1.9 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX61727.1 - 0.029 14.8 0.0 0.059 13.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA PF00004.29 ORX61727.1 - 0.031 14.7 0.2 0.055 13.9 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ORX61727.1 - 0.035 14.0 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 ORX61727.1 - 0.035 14.0 0.0 0.064 13.2 0.0 1.5 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 ORX61727.1 - 0.058 13.1 0.2 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ORX61727.1 - 0.092 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NB-ARC PF00931.22 ORX61727.1 - 0.13 11.4 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.14 ORX61727.1 - 0.14 12.1 0.1 0.46 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Pox_A32 PF04665.12 ORX61727.1 - 0.36 10.3 1.4 0.76 9.2 0.2 1.8 2 0 0 2 2 2 0 Poxvirus A32 protein 7tm_3 PF00003.22 ORX61728.1 - 3.8e-37 128.3 21.2 6e-37 127.6 21.2 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR RELT PF12606.8 ORX61728.1 - 0.16 11.0 1.0 0.51 9.4 1.0 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 T2SSM PF04612.12 ORX61728.1 - 0.36 10.9 2.0 4.9 7.2 0.0 2.8 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein M DUF4293 PF14126.6 ORX61728.1 - 5.5 7.2 10.6 0.87 9.8 5.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) ANF_receptor PF01094.28 ORX61729.1 - 4.3e-30 105.0 0.3 5.6e-30 104.6 0.3 1.0 1 0 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 ORX61729.1 - 1.4e-11 44.6 0.2 1.9e-11 44.2 0.2 1.1 1 0 0 1 1 1 1 Periplasmic binding protein DUF4028 PF13220.6 ORX61729.1 - 0.093 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4028) Ecl1 PF12855.7 ORX61730.1 - 6.1e-07 30.8 11.5 7e-07 30.6 11.5 1.1 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-C6H2 PF15801.5 ORX61730.1 - 0.00095 19.4 0.5 0.00095 19.4 0.5 2.1 1 1 1 2 2 2 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ORX61730.1 - 0.0018 18.3 4.2 0.0018 18.3 4.2 2.1 1 1 1 2 2 2 1 MYND finger DUF2116 PF09889.9 ORX61730.1 - 0.0029 17.5 2.3 0.0029 17.5 2.3 2.1 1 1 1 2 2 2 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) DZR PF12773.7 ORX61730.1 - 0.79 9.8 8.0 2.9 8.0 8.0 2.1 1 1 0 1 1 1 0 Double zinc ribbon CAF1C_H4-bd PF12265.8 ORX61731.1 - 1.7e-26 92.3 0.6 7.4e-26 90.2 0.1 2.4 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ORX61731.1 - 8.4e-24 83.4 9.8 3.1e-06 27.8 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61731.1 - 9.1e-05 22.7 0.8 0.74 10.2 0.2 4.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-C2H2 PF00096.26 ORX61732.1 - 3.6e-16 58.6 8.4 1.6e-08 34.6 1.3 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX61732.1 - 5.7e-10 39.2 7.3 8.2e-05 23.1 0.6 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX61732.1 - 1.2e-09 38.2 14.3 6.7e-08 32.6 2.7 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX61732.1 - 7.8e-05 22.8 5.7 0.058 13.7 0.2 2.7 2 2 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_aberr PF17017.5 ORX61732.1 - 0.0001 22.5 2.5 0.17 12.0 0.1 2.0 1 1 1 2 2 2 2 Aberrant zinc-finger zf-met PF12874.7 ORX61732.1 - 0.00026 21.3 4.2 0.081 13.3 0.5 2.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 ORX61732.1 - 0.0014 19.3 0.6 0.028 15.1 0.1 1.9 1 1 1 2 2 2 1 FOXP coiled-coil domain zf-BED PF02892.15 ORX61732.1 - 0.0044 17.0 4.2 0.1 12.6 0.9 2.2 2 0 0 2 2 2 2 BED zinc finger CHORD PF04968.12 ORX61732.1 - 0.009 16.7 4.0 0.5 11.1 1.0 2.1 1 1 1 2 2 2 2 CHORD zf-C2H2_8 PF15909.5 ORX61732.1 - 0.014 15.6 0.5 0.026 14.8 0.4 1.4 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_6 PF13912.6 ORX61732.1 - 0.025 14.6 0.5 0.025 14.6 0.5 3.3 3 2 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 ORX61732.1 - 0.029 14.1 13.9 1.2 9.0 2.5 2.9 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-LYAR PF08790.11 ORX61732.1 - 0.047 13.6 1.6 5.7 6.9 0.1 2.4 2 1 0 2 2 2 0 LYAR-type C2HC zinc finger IPP-2 PF04979.14 ORX61734.1 - 8.2e-17 62.2 6.6 1e-16 61.9 6.6 1.0 1 0 0 1 1 1 1 Protein phosphatase inhibitor 2 (IPP-2) DNA_pol_phi PF04931.13 ORX61734.1 - 1.2 7.1 7.7 1.3 7.0 7.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi PRP8_domainIV PF12134.8 ORX61735.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 PRP8 domain IV core PDZ_1 PF12812.7 ORX61736.1 - 1.6e-30 104.9 0.0 2.2e-19 69.2 0.0 3.3 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 ORX61736.1 - 3e-21 76.9 0.1 4.9e-16 60.0 0.0 2.7 3 0 0 3 3 3 2 Trypsin-like peptidase domain PDZ_6 PF17820.1 ORX61736.1 - 2.2e-17 62.6 0.4 0.00018 21.3 0.1 4.6 4 0 0 4 4 4 4 PDZ domain PDZ_2 PF13180.6 ORX61736.1 - 8.2e-12 45.3 0.0 0.026 14.8 0.0 4.4 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 ORX61736.1 - 3.9e-08 33.5 0.0 0.0091 16.3 0.0 3.6 3 0 0 3 3 3 3 PDZ domain Tricorn_PDZ PF14685.6 ORX61736.1 - 0.15 12.1 0.1 18 5.4 0.0 3.6 5 0 0 5 5 5 0 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 ORX61736.1 - 0.2 10.3 0.0 0.34 9.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase S46 WD40 PF00400.32 ORX61739.1 - 1e-40 136.9 19.8 1.3e-07 32.2 0.5 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61739.1 - 5e-10 39.6 2.0 0.16 12.3 0.0 4.9 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX61739.1 - 5.8e-07 28.5 7.5 0.056 12.1 0.1 4.5 2 1 2 5 5 5 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ORX61739.1 - 4.4e-05 23.2 1.6 0.0083 15.7 0.3 2.7 1 1 0 2 2 2 2 PQQ-like domain WD40_like PF17005.5 ORX61739.1 - 0.00012 21.5 0.0 0.22 10.8 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain PALB2_WD40 PF16756.5 ORX61739.1 - 0.015 14.3 4.0 0.32 9.9 0.1 3.4 1 1 3 4 4 4 0 Partner and localizer of BRCA2 WD40 domain OrfB_Zn_ribbon PF07282.11 ORX61740.1 - 2.1e-06 27.5 0.5 2.1e-05 24.3 0.5 2.2 1 1 0 1 1 1 1 Putative transposase DNA-binding domain RPAP2_Rtr1 PF04181.13 ORX61741.1 - 0.53 10.6 5.1 15 5.9 5.1 2.6 1 1 0 1 1 1 0 Rtr1/RPAP2 family CxC6 PF18721.1 ORX61741.1 - 0.56 10.5 10.9 3 8.2 3.0 2.7 1 1 1 2 2 2 0 CxC6 like cysteine cluster associated with KDZ transposases Pox_Ag35 PF03286.14 ORX61742.1 - 0.065 13.0 0.5 0.11 12.3 0.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HSP70 PF00012.20 ORX61743.1 - 1.5e-165 551.9 3.1 2.1e-165 551.3 3.1 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX61743.1 - 3.3e-12 45.9 0.8 1.7e-11 43.6 0.0 2.3 3 0 0 3 3 3 1 MreB/Mbl protein DUF4788 PF16032.5 ORX61743.1 - 0.056 12.4 0.0 0.15 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4788) DUF3833 PF12915.7 ORX61743.1 - 0.064 12.8 0.2 0.17 11.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) tRNA-synt_1b PF00579.25 ORX61744.1 - 1.1e-75 254.7 0.0 1.4e-75 254.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Luciferase_N PF05295.11 ORX61744.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Luciferase/LBP N-terminal domain WD40 PF00400.32 ORX61745.1 - 3.1e-25 88.0 18.8 1.7e-06 28.6 0.4 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 ORX61745.1 - 1e-06 27.7 0.1 0.056 12.1 0.0 3.1 3 0 0 3 3 3 2 Nucleoporin Nup120/160 F-box_4 PF15966.5 ORX61745.1 - 0.0031 17.4 0.1 0.007 16.2 0.1 1.7 1 0 0 1 1 1 1 F-box F-box PF00646.33 ORX61745.1 - 0.022 14.6 0.6 0.052 13.5 0.6 1.6 1 0 0 1 1 1 0 F-box domain Nbas_N PF15492.6 ORX61745.1 - 0.042 13.2 0.1 0.59 9.4 0.0 2.3 2 0 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal F-box-like PF12937.7 ORX61746.1 - 0.001 18.9 0.6 0.0034 17.2 0.6 2.0 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ORX61746.1 - 0.002 18.5 6.6 0.028 14.8 2.2 3.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) F-box PF00646.33 ORX61746.1 - 0.11 12.5 0.6 0.43 10.5 0.1 2.3 2 0 0 2 2 2 0 F-box domain LRR_6 PF13516.6 ORX61746.1 - 6.6 7.1 8.6 24 5.3 0.1 4.5 4 0 0 4 4 4 0 Leucine Rich repeat F-box-like PF12937.7 ORX61747.1 - 1.6e-09 37.5 2.0 1.6e-09 37.5 2.0 2.3 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX61747.1 - 3.1e-06 26.9 2.0 8.9e-06 25.5 2.0 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ORX61747.1 - 5.8e-05 23.4 0.1 11 6.6 0.0 4.7 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) F-box_4 PF15966.5 ORX61747.1 - 0.1 12.5 0.4 0.94 9.4 0.1 2.5 2 0 0 2 2 2 0 F-box F-box-like PF12937.7 ORX61748.1 - 6.5e-07 29.1 3.0 5.5e-06 26.2 1.4 2.7 2 0 0 2 2 2 1 F-box-like DUF3760 PF12586.8 ORX61748.1 - 1.6e-06 28.1 0.6 5.3e-06 26.5 0.6 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3760) F-box PF00646.33 ORX61748.1 - 0.037 13.9 3.2 0.043 13.7 0.3 2.7 2 0 0 2 2 2 0 F-box domain BTB PF00651.31 ORX61751.1 - 1.3e-06 28.6 0.0 3e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Y2_Tnp PF04986.13 ORX61751.1 - 0.12 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative transposase Pro_isomerase PF00160.21 ORX61752.1 - 2.9e-42 144.6 0.0 5.8e-42 143.7 0.0 1.5 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD UEV PF05743.13 ORX61753.1 - 5.6e-34 116.6 0.3 6.7e-34 116.4 0.3 1.1 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 ORX61754.1 - 1.1e-26 92.6 0.3 2.3e-26 91.5 0.3 1.6 1 0 0 1 1 1 1 Vps23 core domain DASH_Dam1 PF08653.10 ORX61754.1 - 1.1 9.1 3.5 1.8 8.4 1.4 2.4 1 1 1 2 2 2 0 DASH complex subunit Dam1 Glyco_hydro_31 PF01055.26 ORX61755.1 - 2.3e-86 290.8 6.1 3.1e-86 290.3 6.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 ORX61755.1 - 5.7e-17 61.8 0.1 1.7e-16 60.3 0.1 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like DUF4968 PF16338.5 ORX61755.1 - 1.6e-08 34.7 0.0 3e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) DUF5110 PF17137.4 ORX61755.1 - 0.00028 21.1 0.1 0.00086 19.5 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) Peptidase_M3 PF01432.20 ORX61756.1 - 5.4e-126 421.5 0.0 7.4e-126 421.1 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Vif PF00559.17 ORX61756.1 - 0.043 13.5 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 Retroviral Vif (Viral infectivity) protein Lin-8 PF03353.15 ORX61757.1 - 0.039 13.5 2.4 0.058 13.0 2.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 ORX61757.1 - 0.54 8.5 6.7 0.67 8.2 6.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Med26_C PF15693.5 ORX61757.1 - 0.9 9.7 4.6 0.23 11.6 0.2 2.1 3 0 0 3 3 3 0 Mediator complex subunit 26 C-terminal SR-25 PF10500.9 ORX61757.1 - 1.7 8.2 6.6 3.1 7.4 6.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Vint PF14623.6 ORX61758.1 - 0.012 15.5 0.2 0.013 15.3 0.2 1.1 1 0 0 1 1 1 0 Hint-domain Vps53_N PF04100.12 ORX61759.1 - 1e-108 363.8 14.2 1e-108 363.8 14.2 2.2 3 0 0 3 3 3 1 Vps53-like, N-terminal Vps54_N PF10475.9 ORX61759.1 - 4.8e-07 29.4 11.0 1.2e-06 28.0 11.0 1.6 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex VPS53_C PF16854.5 ORX61759.1 - 1.7e-05 24.8 0.0 1.7e-05 24.8 0.0 2.9 3 0 0 3 3 3 1 Vacuolar protein sorting-associated protein 53 C-terminus Zw10 PF06248.13 ORX61759.1 - 0.014 14.0 15.3 0.16 10.5 12.3 3.0 3 0 0 3 3 3 0 Centromere/kinetochore Zw10 DUF489 PF04356.12 ORX61759.1 - 0.016 15.2 12.4 0.53 10.3 0.1 3.0 1 1 0 2 2 2 0 Protein of unknown function (DUF489) MHCassoc_trimer PF08831.10 ORX61759.1 - 0.062 13.3 0.3 8.4 6.5 0.1 2.9 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain FUSC PF04632.12 ORX61759.1 - 0.16 10.5 4.4 0.3 9.6 4.4 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sigma70_ner PF04546.13 ORX61759.1 - 0.39 10.6 11.6 2.4 8.0 2.7 2.5 1 1 1 2 2 2 0 Sigma-70, non-essential region F_actin_bind PF08919.10 ORX61759.1 - 0.55 10.4 6.0 0.41 10.8 0.8 3.2 2 0 0 2 2 2 0 F-actin binding Mei5_like PF17021.5 ORX61759.1 - 0.68 10.0 7.0 0.25 11.4 0.3 3.0 3 0 0 3 3 3 0 Putative double-strand recombination repair-like RSS_P20 PF11757.8 ORX61759.1 - 8.8 6.8 7.8 13 6.3 2.6 3.6 2 1 1 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain CAP_N PF01213.19 ORX61760.1 - 1.8e-112 375.9 0.9 1.8e-112 375.9 0.9 1.6 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 ORX61760.1 - 2.1e-62 209.4 4.2 2.9e-62 208.9 4.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ORX61760.1 - 0.00037 20.2 3.9 0.001 18.8 3.9 1.6 1 1 0 1 1 1 1 Tubulin binding cofactor C FERM_N PF09379.10 ORX61760.1 - 0.0041 17.0 0.1 0.013 15.5 0.1 1.8 1 1 0 1 1 1 1 FERM N-terminal domain PAR1 PF06521.11 ORX61760.1 - 0.047 13.3 0.3 0.047 13.3 0.3 1.8 2 0 0 2 2 2 0 PAR1 protein hnRNP_Q_AcD PF18360.1 ORX61760.1 - 0.13 12.2 0.0 0.91 9.5 0.0 2.2 2 0 0 2 2 2 0 Heterogeneous nuclear ribonucleoprotein Q acidic domain HSP70 PF00012.20 ORX61761.1 - 3.5e-89 299.6 9.0 3.5e-89 299.6 9.0 2.1 2 1 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ORX61761.1 - 1.3e-07 30.7 1.2 1.1e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 MreB/Mbl protein Tfb4 PF03850.14 ORX61762.1 - 7.5e-101 337.2 1.8 8.8e-101 337.0 1.8 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Keratin_B2_2 PF13885.6 ORX61763.1 - 1e-15 57.4 24.2 5.9e-05 22.9 4.4 4.4 1 1 3 4 4 4 4 Keratin, high sulfur B2 protein Pentapeptide_2 PF01469.18 ORX61763.1 - 0.0032 17.3 0.0 10 6.1 0.0 3.4 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Keratin_B2 PF01500.17 ORX61763.1 - 0.01 15.8 22.9 2.8 7.9 22.9 2.6 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein ASFV_J13L PF05568.11 ORX61763.1 - 0.38 10.5 23.7 1.8e+04 -5.3 23.7 3.2 1 1 0 1 1 1 0 African swine fever virus J13L protein DUF368 PF04018.13 ORX61764.1 - 0.0028 17.3 0.5 0.004 16.8 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF368) CDC37_C PF08564.10 ORX61764.1 - 0.1 12.7 0.7 0.21 11.7 0.4 1.7 1 1 0 1 1 1 0 Cdc37 C terminal domain DUF935 PF06074.12 ORX61764.1 - 0.11 11.2 1.6 0.19 10.4 0.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF935) BAF1_ABF1 PF04684.13 ORX61764.1 - 0.14 11.2 4.6 0.23 10.5 4.6 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Importin_rep_6 PF18829.1 ORX61764.1 - 2.1 8.5 9.1 1.9 8.7 7.0 2.0 1 1 0 1 1 1 0 Importin repeat 6 BIRC6 PF12356.8 ORX61764.1 - 3.2 7.1 4.7 0.49 9.8 0.4 1.7 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 Snf7 PF03357.21 ORX61764.1 - 3.8 7.1 9.4 5.3 6.6 8.6 1.7 1 1 0 1 1 1 0 Snf7 Sec62 PF03839.16 ORX61765.1 - 2.8e-51 174.1 0.1 3.7e-51 173.7 0.1 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 Fun_ATP-synt_8 PF05933.13 ORX61765.1 - 0.013 15.6 2.1 0.033 14.3 2.1 1.6 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) Kei1 PF08552.11 ORX61765.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DGCR6 PF07324.11 ORX61766.1 - 2.7e-06 27.1 10.0 1.1e-05 25.2 9.7 1.9 1 1 0 1 1 1 1 DiGeorge syndrome critical region 6 (DGCR6) protein Cas_Csm6 PF09659.10 ORX61766.1 - 0.002 17.0 2.9 0.0026 16.6 2.9 1.1 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csm6) Cas_GSU0053 PF09617.10 ORX61766.1 - 0.12 12.3 2.0 0.2 11.6 1.4 1.7 1 1 1 2 2 2 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) DUF1977 PF09320.11 ORX61766.1 - 0.65 10.3 8.1 0.14 12.4 4.2 2.0 2 2 0 2 2 2 0 Domain of unknown function (DUF1977) US22 PF02393.16 ORX61767.1 - 5.1 7.4 9.1 11 6.3 9.1 1.8 1 1 0 1 1 1 0 US22 like COOH-NH2_lig PF14395.6 ORX61769.1 - 0.031 13.5 0.4 0.039 13.2 0.4 1.1 1 0 0 1 1 1 0 Phage phiEco32-like COOH.NH2 ligase-type 2 OKR_DC_1_N PF03709.15 ORX61770.1 - 0.1 12.9 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Kelch_4 PF13418.6 ORX61771.1 - 4.4e-09 36.2 7.1 0.0075 16.2 3.4 4.4 3 1 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX61771.1 - 5.1e-09 35.6 0.6 4.6e-05 22.9 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ORX61771.1 - 5.1e-08 33.0 11.4 0.013 15.8 0.0 4.3 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX61771.1 - 5.5e-07 29.4 0.3 0.01 15.8 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ORX61771.1 - 1.8e-06 28.1 7.3 0.0082 16.4 0.9 4.1 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ORX61771.1 - 1.6e-05 24.7 0.2 0.005 16.8 0.1 3.2 3 0 0 3 3 3 1 Kelch motif VSP PF03302.13 ORX61771.1 - 0.04 12.8 0.3 0.061 12.2 0.3 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein SKG6 PF08693.10 ORX61771.1 - 0.17 11.3 3.6 0.34 10.3 3.6 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Adeno_E3_CR2 PF02439.15 ORX61771.1 - 0.18 11.6 0.3 0.45 10.3 0.3 1.6 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TrkH PF02386.16 ORX61773.1 - 2.2e-92 310.1 0.8 2.9e-92 309.7 0.8 1.1 1 0 0 1 1 1 1 Cation transport protein PPR_2 PF13041.6 ORX61774.1 - 6.6e-18 64.6 0.0 7.4e-05 22.9 0.0 8.6 7 2 2 9 9 9 4 PPR repeat family PPR PF01535.20 ORX61774.1 - 2.3e-11 43.1 0.0 5.9 7.4 0.0 9.8 11 0 0 11 11 10 1 PPR repeat TPR_16 PF13432.6 ORX61774.1 - 0.0005 20.7 8.2 0.77 10.5 0.5 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat PPR_3 PF13812.6 ORX61774.1 - 0.00058 19.9 0.1 3.9 7.6 0.0 5.1 6 0 0 6 6 6 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ORX61774.1 - 0.003 17.0 0.0 9.6 5.5 0.0 3.6 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX61774.1 - 0.067 12.9 0.4 1 9.1 0.1 3.3 4 0 0 4 4 4 0 PPR repeat TPR_19 PF14559.6 ORX61774.1 - 0.1 13.1 10.2 1.4 9.4 0.2 5.2 5 2 1 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX61774.1 - 0.14 12.4 9.2 0.6 10.4 0.4 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61774.1 - 0.16 12.2 4.2 22 5.5 0.1 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX61774.1 - 0.21 12.5 12.9 1.7 9.7 0.3 6.3 4 2 3 7 7 7 0 Tetratricopeptide repeat DUF2946 PF11162.8 ORX61774.1 - 9.1 7.0 7.4 0.73 10.5 0.7 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF2946) WD40 PF00400.32 ORX61775.1 - 9.9e-11 42.0 4.5 0.73 10.8 0.2 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61775.1 - 0.0028 17.9 0.5 16 5.8 0.0 4.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain NUP50 PF08911.11 ORX61776.1 - 0.025 15.3 0.0 0.074 13.7 0.0 1.8 1 0 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) CRAL_TRIO PF00650.20 ORX61780.1 - 7.4e-36 123.3 0.1 1.2e-35 122.5 0.1 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX61780.1 - 4.1e-10 39.7 0.1 1.2e-09 38.2 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX61780.1 - 4.8e-07 30.0 0.3 1.2e-06 28.7 0.1 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain CRAL_TRIO PF00650.20 ORX61781.1 - 3.7e-32 111.3 0.3 6.4e-32 110.5 0.3 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX61781.1 - 1.6e-11 44.2 4.5 1.8e-11 44.0 1.7 2.5 2 1 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX61781.1 - 1.3e-05 25.4 0.1 2.1e-05 24.7 0.1 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Urocanase_N PF17391.2 ORX61781.1 - 0.18 11.5 0.0 0.5 10.1 0.0 1.7 1 0 0 1 1 1 0 Urocanase N-terminal domain DUF5427 PF10310.9 ORX61782.1 - 6.7e-45 153.9 8.8 3.7e-40 138.3 2.7 3.2 2 1 0 2 2 2 2 Family of unknown function (DUF5427) DUF719 PF05334.13 ORX61782.1 - 0.0029 17.8 0.8 0.0078 16.4 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF719) Med4 PF10018.9 ORX61782.1 - 0.095 12.4 0.2 0.095 12.4 0.2 2.1 3 0 0 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 Prominin PF05478.11 ORX61782.1 - 0.21 9.5 0.7 0.32 8.9 0.7 1.2 1 0 0 1 1 1 0 Prominin FMN_red PF03358.15 ORX61783.1 - 1.7e-17 63.6 0.0 2.5e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX61783.1 - 8.2e-10 38.7 0.0 1.1e-09 38.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX61783.1 - 0.00043 20.5 0.1 0.25 11.5 0.0 2.5 1 1 1 2 2 2 2 Flavodoxin Flavodoxin_5 PF12724.7 ORX61783.1 - 0.012 15.8 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin domain NUDIX PF00293.28 ORX61784.1 - 1.6e-25 89.6 0.0 2.2e-25 89.2 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain ADIP PF11559.8 ORX61787.1 - 3.8e-18 66.0 17.6 3.8e-18 66.0 17.6 3.5 3 1 0 3 3 3 1 Afadin- and alpha -actinin-Binding UCH PF00443.29 ORX61787.1 - 0.0042 16.6 3.3 0.0042 16.6 3.3 2.2 1 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_C PF18031.1 ORX61787.1 - 0.59 10.1 0.1 0.59 10.1 0.1 4.0 5 0 0 5 5 5 0 Ubiquitin carboxyl-terminal hydrolases TMPIT PF07851.13 ORX61787.1 - 6.4 5.9 26.3 1.4 8.1 14.6 2.6 2 1 0 2 2 2 0 TMPIT-like protein HLH PF00010.26 ORX61789.1 - 6.5e-13 48.4 2.8 1.3e-12 47.5 2.8 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain SLX9 PF15341.6 ORX61789.1 - 0.042 14.2 1.2 0.57 10.6 1.9 2.0 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 CAP_GLY PF01302.25 ORX61790.1 - 3.6e-20 71.8 0.1 5e-20 71.3 0.1 1.2 1 0 0 1 1 1 1 CAP-Gly domain Syntaxin-18_N PF10496.9 ORX61791.1 - 5.5e-11 42.6 3.6 1.9e-10 40.8 0.0 3.3 3 1 0 3 3 3 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 ORX61791.1 - 1.2e-05 25.2 1.5 1.4e-05 25.0 0.1 1.8 2 0 0 2 2 2 1 SNARE domain DDE_Tnp_IS240 PF13610.6 ORX61791.1 - 0.0016 18.7 0.5 1 9.6 0.0 2.5 2 0 0 2 2 2 2 DDE domain Corazonin PF17308.2 ORX61791.1 - 2 8.8 7.2 0.84 10.0 0.2 3.0 3 1 0 3 3 3 0 Pro-corazonin DUF3391 PF11871.8 ORX61791.1 - 4.6 7.8 9.5 13 6.3 2.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) E1-E2_ATPase PF00122.20 ORX61792.1 - 8.7e-35 119.9 0.0 1.8e-34 118.8 0.0 1.5 1 0 0 1 1 1 1 E1-E2 ATPase P5-ATPase PF12409.8 ORX61792.1 - 4.9e-27 94.5 0.1 1.6e-26 92.9 0.1 1.9 1 0 0 1 1 1 1 P5-type ATPase cation transporter Hydrolase PF00702.26 ORX61792.1 - 2.5e-11 44.3 0.1 0.00071 19.9 0.0 3.3 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ORX61792.1 - 1.4e-06 28.3 0.0 2.8e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX61792.1 - 4.7e-06 26.2 0.1 1.5e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cwf_Cwc_15 PF04889.12 ORX61792.1 - 0.098 12.4 2.8 0.14 11.8 2.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HSF_DNA-bind PF00447.17 ORX61794.1 - 3.9e-21 75.5 0.4 1.1e-20 74.0 0.1 1.8 2 0 0 2 2 2 1 HSF-type DNA-binding SPX PF03105.19 ORX61794.1 - 0.0098 15.8 0.4 0.023 14.6 0.4 1.6 1 1 0 1 1 1 1 SPX domain CDP-OH_P_transf PF01066.21 ORX61795.1 - 5e-13 49.6 0.5 5e-13 49.6 0.5 2.5 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase LRR_8 PF13855.6 ORX61796.1 - 1.9e-20 72.3 35.2 6e-07 29.1 5.0 4.5 2 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ORX61796.1 - 3e-20 72.0 40.5 9e-09 35.5 2.1 6.4 2 2 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ORX61796.1 - 1.4e-15 57.3 14.8 1.2e-11 44.5 1.4 3.5 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 ORX61796.1 - 8.3e-05 22.3 30.1 3.8 7.8 0.1 8.8 9 0 0 9 9 9 3 Leucine Rich repeat LRR_5 PF13306.6 ORX61796.1 - 0.93 9.5 5.8 13 5.8 0.2 2.6 1 1 1 2 2 2 0 BspA type Leucine rich repeat region (6 copies) LRR_1 PF00560.33 ORX61796.1 - 3.6 8.5 24.5 56 4.9 0.1 7.8 8 2 0 8 8 8 0 Leucine Rich Repeat Pyr_redox_2 PF07992.14 ORX61797.1 - 3.9e-07 29.6 0.0 6.2e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX61797.1 - 0.0011 18.9 0.0 0.0033 17.4 0.0 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Asp_Glu_race PF01177.22 ORX61797.1 - 0.0024 17.7 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase NAD_binding_8 PF13450.6 ORX61797.1 - 0.0065 16.7 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain RMI1_N PF08585.12 ORX61801.1 - 2.9e-25 89.3 0.0 3.8e-24 85.7 0.0 2.1 1 1 0 1 1 1 1 RecQ mediated genome instability protein DUF1825 PF08855.10 ORX61801.1 - 0.047 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1825) WD40 PF00400.32 ORX61802.1 - 1.6e-34 117.3 21.0 1.4e-09 38.4 0.3 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61802.1 - 7.8e-15 54.9 2.1 0.093 13.0 0.0 4.6 2 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX61802.1 - 1.1e-07 31.9 0.0 0.33 10.8 0.0 3.6 2 1 2 4 4 4 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ORX61802.1 - 0.00081 18.8 0.0 0.037 13.3 0.0 2.7 1 1 1 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ORX61802.1 - 0.0037 16.9 0.0 0.0069 16.0 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4221) BBS2_Mid PF14783.6 ORX61802.1 - 0.011 15.8 0.0 0.42 10.7 0.1 2.9 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Coatomer_WDAD PF04053.14 ORX61802.1 - 0.013 14.6 0.4 0.41 9.6 0.0 2.6 2 1 1 3 3 3 0 Coatomer WD associated region Vps16_N PF04841.13 ORX61802.1 - 0.029 13.1 0.1 0.056 12.2 0.1 1.4 1 0 0 1 1 1 0 Vps16, N-terminal region HPS3_N PF14761.6 ORX61802.1 - 0.059 12.9 0.0 0.79 9.2 0.0 2.3 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Nucleoporin_N PF08801.11 ORX61802.1 - 0.15 10.8 1.6 0.82 8.3 0.1 2.6 2 1 1 3 3 3 0 Nup133 N terminal like Fungal_trans PF04082.18 ORX61803.1 - 0.0078 15.3 6.1 0.012 14.6 4.5 2.1 2 1 0 2 2 2 1 Fungal specific transcription factor domain Myb_DNA-binding PF00249.31 ORX61804.1 - 4.5e-06 26.8 0.0 7.8e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Peptidase_S9 PF00326.21 ORX61805.1 - 5e-45 153.6 0.0 7.4e-45 153.0 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ORX61805.1 - 5.9e-10 39.1 0.0 1.2e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ORX61805.1 - 2.4e-05 23.8 0.1 0.043 13.1 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ORX61805.1 - 3.2e-05 23.9 0.0 9e-05 22.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ORX61805.1 - 0.00013 21.7 0.2 0.0075 15.9 0.0 2.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold BAAT_C PF08840.11 ORX61805.1 - 0.00014 21.9 0.0 0.0015 18.5 0.0 2.3 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 ORX61805.1 - 0.041 13.5 0.0 0.27 10.8 0.0 2.0 1 1 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_4 PF08386.10 ORX61805.1 - 0.049 13.7 0.0 0.17 12.0 0.0 1.8 2 0 0 2 2 2 0 TAP-like protein FSH1 PF03959.13 ORX61805.1 - 0.063 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DUF3141 PF11339.8 ORX61805.1 - 0.1 11.0 0.0 0.17 10.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Peptidase_S9 PF00326.21 ORX61806.1 - 6.2e-48 163.1 0.0 1.1e-47 162.2 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ORX61806.1 - 1.8e-10 40.8 0.0 4.3e-10 39.5 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ORX61806.1 - 2.6e-06 27.5 0.0 0.00026 21.0 0.0 2.4 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.20 ORX61806.1 - 4.1e-05 23.4 0.1 0.037 13.6 0.0 2.4 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ORX61806.1 - 6.3e-05 22.9 0.0 0.00049 20.0 0.0 2.4 2 1 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX61806.1 - 8.3e-05 22.0 0.0 0.0099 15.2 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ORX61806.1 - 0.0012 18.9 0.0 0.0033 17.5 0.0 1.7 2 0 0 2 2 2 1 TAP-like protein FSH1 PF03959.13 ORX61806.1 - 0.0014 18.4 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) AXE1 PF05448.12 ORX61806.1 - 0.0063 15.2 0.3 0.038 12.7 0.0 2.1 2 1 0 2 2 2 1 Acetyl xylan esterase (AXE1) UPF0146 PF03686.13 ORX61806.1 - 0.073 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) PD40 PF07676.12 ORX61806.1 - 0.079 12.9 0.2 0.2 11.6 0.2 1.7 1 0 0 1 1 1 0 WD40-like Beta Propeller Repeat PAF-AH_p_II PF03403.13 ORX61806.1 - 0.1 11.1 0.0 2 6.8 0.0 2.1 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Peptidase_S15 PF02129.18 ORX61806.1 - 0.11 12.1 0.1 2.8 7.5 0.0 2.2 1 1 1 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF829 PF05705.14 ORX61806.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) FMN_dh PF01070.18 ORX61807.1 - 0.086 11.9 0.2 0.095 11.7 0.2 1.0 1 0 0 1 1 1 0 FMN-dependent dehydrogenase NUP50 PF08911.11 ORX61809.1 - 0.0083 16.8 0.0 0.031 15.0 0.0 2.0 1 0 0 1 1 1 1 NUP50 (Nucleoporin 50 kDa) DUF3712 PF12505.8 ORX61810.1 - 1.9e-62 209.1 52.3 1.6e-22 80.0 0.3 7.8 8 1 0 8 8 8 4 Protein of unknown function (DUF3712) LEA_2 PF03168.13 ORX61810.1 - 0.00024 21.6 16.6 0.27 11.8 0.1 7.8 8 0 0 8 8 8 2 Late embryogenesis abundant protein Myb_DNA-bind_7 PF15963.5 ORX61811.1 - 1.8e-17 63.0 0.3 4e-17 61.9 0.3 1.5 1 0 0 1 1 1 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 ORX61811.1 - 1.8e-07 31.2 0.0 3.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain PQ-loop PF04193.14 ORX61812.1 - 2.9e-17 62.2 10.0 7.1e-12 44.9 0.2 3.3 3 0 0 3 3 3 2 PQ loop repeat ER_lumen_recept PF00810.18 ORX61812.1 - 0.00017 22.4 7.3 0.0067 17.3 3.7 2.4 2 0 0 2 2 2 2 ER lumen protein retaining receptor DAD PF02109.16 ORX61812.1 - 0.12 12.7 2.9 8.8 6.7 0.1 2.6 2 0 0 2 2 2 0 DAD family Cyt_c_ox_IV PF12270.8 ORX61812.1 - 0.18 11.9 0.1 0.18 11.9 0.1 3.0 3 1 1 4 4 4 0 Cytochrome c oxidase subunit IV Metallophos PF00149.28 ORX61813.1 - 2.8e-11 44.3 1.4 2.8e-11 44.3 1.4 2.1 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Kelch_4 PF13418.6 ORX61814.1 - 1.3e-09 37.9 10.4 0.025 14.6 0.3 5.2 5 1 0 5 5 5 4 Galactose oxidase, central domain Kelch_1 PF01344.25 ORX61814.1 - 4.5e-07 29.3 2.5 0.0028 17.2 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ORX61814.1 - 9.8e-07 28.6 20.9 0.044 13.8 0.1 6.5 7 0 0 7 7 7 3 Kelch motif Kelch_3 PF13415.6 ORX61814.1 - 3.2e-06 27.3 6.3 7.7e-05 22.9 0.1 5.8 6 2 0 6 6 6 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ORX61814.1 - 1.2e-05 25.4 8.5 0.078 13.3 0.2 5.2 5 0 0 5 5 5 2 Kelch motif Rax2 PF12768.7 ORX61814.1 - 8e-05 22.2 5.6 0.0017 17.9 5.6 2.3 1 1 0 1 1 1 1 Cortical protein marker for cell polarity Kelch_2 PF07646.15 ORX61814.1 - 0.00036 20.4 5.6 0.041 13.9 0.5 4.7 5 1 0 5 5 5 1 Kelch motif TMEM154 PF15102.6 ORX61814.1 - 0.002 18.0 0.0 0.0056 16.6 0.0 1.7 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 ORX61814.1 - 0.0034 16.8 1.9 0.0099 15.3 1.9 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain VSP PF03302.13 ORX61814.1 - 0.028 13.3 1.0 0.05 12.5 1.0 1.3 1 0 0 1 1 1 0 Giardia variant-specific surface protein Amnionless PF14828.6 ORX61814.1 - 0.2 10.4 0.0 0.3 9.8 0.0 1.2 1 0 0 1 1 1 0 Amnionless Glyco_transf_24 PF18404.1 ORX61815.1 - 8.8e-152 504.0 2.2 1.6e-151 503.2 1.3 1.9 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 ORX61815.1 - 6.6e-55 186.8 0.6 1.6e-53 182.3 0.0 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 ORX61815.1 - 4.4e-36 123.3 0.0 1.4e-35 121.7 0.0 2.0 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_13 PF18401.1 ORX61815.1 - 7.2e-35 119.9 1.6 2.9e-34 117.9 0.4 2.5 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ORX61815.1 - 2e-33 115.9 0.7 3.6e-33 115.0 0.7 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ORX61815.1 - 8.9e-28 97.7 0.0 7.7e-27 94.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain Glyco_transf_8 PF01501.20 ORX61815.1 - 3.3e-05 23.6 0.0 6.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 8 DUF1682 PF07946.14 ORX61815.1 - 0.013 14.7 0.3 0.022 14.0 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TP6A_N PF04406.14 ORX61815.1 - 0.19 11.8 1.5 20 5.3 0.2 2.5 2 0 0 2 2 2 0 Type IIB DNA topoisomerase OrfB_Zn_ribbon PF07282.11 ORX61816.1 - 0.0028 17.5 3.7 0.0028 17.5 3.7 3.0 2 1 0 2 2 2 1 Putative transposase DNA-binding domain OrfB_Zn_ribbon PF07282.11 ORX61838.1 - 6.1e-08 32.5 0.7 6.1e-08 32.5 0.7 3.2 3 0 0 3 3 3 1 Putative transposase DNA-binding domain DZR PF12773.7 ORX61838.1 - 0.79 9.8 16.1 0.34 11.0 1.2 3.2 2 1 0 2 2 2 0 Double zinc ribbon zf-CCHC_6 PF15288.6 ORX61838.1 - 1.5 8.7 8.6 3.5 7.5 0.9 2.7 2 0 0 2 2 2 0 Zinc knuckle DUF4407 PF14362.6 ORX61838.1 - 1.6 8.0 7.5 2.2 7.6 2.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Acyltransf_C PF16076.5 ORX61840.1 - 1.7e-10 40.8 0.1 5e-10 39.3 0.1 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus Acyltransferase PF01553.21 ORX61840.1 - 2.6e-09 36.8 0.0 3.8e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 Acyltransferase Baculo_RING PF05883.11 ORX61840.1 - 0.14 12.2 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain ABC_export PF16962.5 ORX61840.1 - 0.31 9.4 0.3 0.38 9.1 0.3 1.1 1 0 0 1 1 1 0 Putative ABC exporter WD40 PF00400.32 ORX61842.1 - 5.6e-22 77.6 8.0 0.00031 21.5 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX61842.1 - 0.0002 21.6 1.3 0.18 12.1 0.1 4.2 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Tim17 PF02466.19 ORX61843.1 - 1.5e-08 35.0 0.8 0.00065 20.1 0.1 2.6 2 1 0 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family TMEM135_C_rich PF15982.5 ORX61843.1 - 3.8e-06 27.5 4.4 1.4e-05 25.7 0.3 3.0 3 0 0 3 3 3 1 N-terminal cysteine-rich region of Transmembrane protein 135 TPT PF03151.16 ORX61844.1 - 4.4e-42 144.4 22.2 5.1e-42 144.2 22.2 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ORX61844.1 - 5.4e-15 55.4 23.0 7.5e-15 54.9 23.0 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX61844.1 - 7.1e-11 42.4 35.8 1.2e-06 28.8 13.7 2.2 2 0 0 2 2 2 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ORX61844.1 - 0.0018 17.5 8.1 0.0029 16.8 0.3 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter ThiF PF00899.21 ORX61845.1 - 1.8e-25 89.7 0.0 2.7e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 ThiF family DAO PF01266.24 ORX61845.1 - 0.00079 19.1 0.2 0.0015 18.2 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ORX61845.1 - 0.004 16.5 0.1 0.0067 15.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Sacchrp_dh_NADP PF03435.18 ORX61845.1 - 0.027 14.7 0.0 0.52 10.6 0.0 2.3 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 ORX61845.1 - 0.039 14.4 0.0 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding ApbA PF02558.16 ORX61845.1 - 0.062 12.9 0.0 0.22 11.1 0.0 2.0 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Shikimate_DH PF01488.20 ORX61845.1 - 0.13 12.4 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AlaDh_PNT_C PF01262.21 ORX61845.1 - 0.14 11.5 0.1 0.24 10.7 0.1 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ORX61845.1 - 0.22 10.6 0.2 0.32 10.0 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 ORX61845.1 - 0.35 10.2 1.8 1.5 8.1 0.1 2.4 3 0 0 3 3 3 0 FAD dependent oxidoreductase HSP70 PF00012.20 ORX61846.1 - 3.5e-259 861.1 8.9 4e-259 860.9 8.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX61846.1 - 1.4e-16 60.3 0.0 1.7e-15 56.7 0.0 2.1 1 1 1 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ORX61846.1 - 0.0046 16.7 0.0 0.014 15.2 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 ORX61846.1 - 0.016 14.5 0.1 0.039 13.2 0.1 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 ORX61846.1 - 0.019 14.5 0.1 3.8 6.9 0.1 2.4 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family SAPIS-gp6 PF16722.5 ORX61846.1 - 0.044 14.2 1.1 0.13 12.7 1.1 1.8 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus DDR PF08841.10 ORX61846.1 - 0.051 12.6 0.2 1.2 8.0 0.1 2.3 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Prefoldin_2 PF01920.20 ORX61846.1 - 0.14 12.2 1.6 1.1 9.2 1.5 2.3 2 1 0 2 2 2 0 Prefoldin subunit NOP19 PF10863.8 ORX61846.1 - 0.36 10.6 3.0 2.2 8.1 0.1 2.7 3 0 0 3 3 3 0 Nucleolar protein 19 DUF1840 PF08895.11 ORX61846.1 - 2.7 8.4 4.6 3.1 8.2 0.6 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1840) GARP PF16731.5 ORX61846.1 - 4.6 6.9 8.3 17 5.1 5.3 2.3 2 0 0 2 2 2 0 Glutamic acid/alanine-rich protein of Trypanosoma Plasmod_MYXSPDY PF07981.11 ORX61847.1 - 0.27 11.2 1.1 0.69 10.0 1.1 1.7 1 0 0 1 1 1 0 Plasmodium repeat_MYXSPDY UBX PF00789.20 ORX61849.1 - 4.7e-07 29.9 0.0 1e-06 28.8 0.0 1.6 1 0 0 1 1 1 1 UBX domain TFR_dimer PF04253.15 ORX61850.1 - 1.3e-15 57.6 0.0 3e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 ORX61850.1 - 2.3e-10 40.5 0.0 6.2e-10 39.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M28 PA PF02225.22 ORX61850.1 - 5.5e-07 29.5 0.0 1.6e-06 28.1 0.0 1.7 2 0 0 2 2 2 1 PA domain GerA PF03323.13 ORX61850.1 - 0.17 10.3 0.7 0.26 9.7 0.7 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein DUF3759 PF12585.8 ORX61851.1 - 1.2e-35 121.4 8.1 1.4e-35 121.2 8.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Peptidase_M24 PF00557.24 ORX61852.1 - 1.8e-52 178.1 0.0 2.4e-52 177.7 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 ORX61852.1 - 9.4e-17 61.1 11.8 2.4e-16 59.7 11.8 1.8 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ORX61852.1 - 0.0037 17.3 8.0 0.0078 16.3 8.0 1.6 1 0 0 1 1 1 1 MYND finger DUF2116 PF09889.9 ORX61852.1 - 0.037 14.0 1.9 0.076 13.0 1.9 1.5 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DBR1 PF05011.13 ORX61853.1 - 3.9e-26 92.1 0.1 6.4e-26 91.4 0.1 1.3 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 ORX61853.1 - 1.4e-12 48.5 2.0 3.2e-12 47.4 2.0 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX61853.1 - 0.039 14.2 0.0 0.072 13.3 0.0 1.5 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain zf_UBZ PF18439.1 ORX61854.1 - 0.011 15.3 6.1 0.18 11.4 0.2 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger UVR PF02151.19 ORX61854.1 - 0.092 12.5 4.9 0.039 13.7 1.5 2.2 2 0 0 2 2 2 0 UvrB/uvrC motif VCH_CASS14 PF18315.1 ORX61854.1 - 0.16 12.0 0.1 0.47 10.5 0.1 1.8 1 0 0 1 1 1 0 Integron cassette protein VCH_CASS1 chain GAGA PF09237.11 ORX61854.1 - 1.2 8.9 4.3 2.1 8.2 0.4 2.7 2 0 0 2 2 2 0 GAGA factor OrsD PF12013.8 ORX61854.1 - 4.4 7.8 16.7 2 8.9 4.5 4.4 3 2 2 5 5 5 0 Orsellinic acid/F9775 biosynthesis cluster protein D RINGv PF12906.7 ORX61855.1 - 2.1e-11 43.8 13.1 4.4e-11 42.7 13.1 1.6 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 ORX61855.1 - 0.00017 21.8 12.5 0.00042 20.6 12.5 1.7 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX61855.1 - 7.3 7.0 12.7 36 4.7 12.4 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain MTS PF05175.14 ORX61856.1 - 7.6e-10 38.6 0.0 1.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX61856.1 - 2.8e-08 34.4 0.0 7.3e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX61856.1 - 6.3e-08 32.6 0.0 1.1e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ORX61856.1 - 4.7e-05 22.9 0.0 7.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 ORX61856.1 - 0.00017 22.3 0.1 0.00082 20.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.18 ORX61856.1 - 0.00021 21.0 0.0 0.00038 20.2 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PCMT PF01135.19 ORX61856.1 - 0.00042 20.1 0.0 0.00072 19.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ORX61856.1 - 0.00058 19.7 0.0 0.0017 18.3 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 ORX61856.1 - 0.0032 17.0 0.0 0.0053 16.3 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_11 PF08241.12 ORX61856.1 - 0.0037 17.9 0.0 0.0086 16.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_10 PF05971.12 ORX61856.1 - 0.029 13.7 0.0 0.043 13.1 0.0 1.2 1 0 0 1 1 1 0 RNA methyltransferase PBP1_TM PF14812.6 ORX61856.1 - 0.066 13.6 4.0 0.14 12.6 4.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MMgT PF10270.9 ORX61857.1 - 1.7e-14 54.0 0.7 2.6e-14 53.4 0.7 1.4 1 1 0 1 1 1 1 Membrane magnesium transporter DUF1743 PF08489.11 ORX61857.1 - 0.029 14.4 0.1 0.17 12.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1743) UPF0014 PF03649.13 ORX61858.1 - 1.9e-70 237.0 24.6 2.1e-70 236.8 24.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0014) PIG-F PF06699.11 ORX61858.1 - 0.037 14.2 0.5 0.037 14.2 0.5 2.3 2 1 0 2 2 2 0 GPI biosynthesis protein family Pig-F DUF5592 PF17332.2 ORX61858.1 - 0.062 13.9 7.0 0.15 12.6 7.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5592) SPC12 PF06645.13 ORX61858.1 - 0.072 13.2 0.6 0.072 13.2 0.6 3.6 4 1 2 6 6 6 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Deltameth_res PF16020.5 ORX61858.1 - 0.14 12.0 0.3 0.14 12.0 0.3 2.7 3 1 0 3 3 3 0 Deltamethrin resistance BPD_transp_1 PF00528.22 ORX61858.1 - 0.15 11.8 25.2 3.2 7.4 25.2 2.9 1 1 1 2 2 2 0 Binding-protein-dependent transport system inner membrane component Ac76 PF05814.11 ORX61858.1 - 0.25 11.4 5.3 0.72 9.9 5.3 1.9 1 0 0 1 1 1 0 Orf76 (Ac76) AC_N PF16214.5 ORX61858.1 - 0.35 9.9 2.0 0.46 9.6 2.0 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region GPHR_N PF12537.8 ORX61859.1 - 2e-13 50.2 0.1 4e-13 49.2 0.1 1.5 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal LMBR1 PF04791.16 ORX61859.1 - 3.6e-05 22.9 2.8 4.3e-05 22.6 2.8 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein ABA_GPCR PF12430.8 ORX61860.1 - 1.4e-28 99.8 6.4 1.7e-28 99.6 6.4 1.0 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor CcmH PF03918.14 ORX61860.1 - 0.003 16.9 0.1 0.0064 15.8 0.1 1.5 1 0 0 1 1 1 1 Cytochrome C biogenesis protein Phage_base_V PF04717.12 ORX61860.1 - 0.17 11.8 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Type VI secretion system, phage-baseplate injector DUF3311 PF11755.8 ORX61860.1 - 0.32 11.0 3.8 0.34 10.9 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3311) Nucleoporin_N PF08801.11 ORX61861.1 - 1.4e-52 178.9 0.8 2.1e-52 178.3 0.8 1.3 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 ORX61861.1 - 4.9e-17 61.9 1.2 7e-17 61.4 1.2 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal MOR2-PAG1_N PF14222.6 ORX61864.1 - 3.4e-88 297.0 1.8 4e-59 201.0 1.2 2.3 2 0 0 2 2 2 2 Cell morphogenesis N-terminal MOR2-PAG1_mid PF14228.6 ORX61864.1 - 4.7e-57 193.5 20.5 2e-26 92.0 0.8 5.4 5 1 1 6 6 6 4 Cell morphogenesis central region MOR2-PAG1_C PF14225.6 ORX61864.1 - 1.4e-39 136.5 0.6 1.4e-39 136.5 0.6 2.8 3 0 0 3 3 3 1 Cell morphogenesis C-terminal HD_3 PF13023.6 ORX61865.1 - 5.8e-46 156.4 1.7 7.1e-46 156.1 1.7 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 ORX61865.1 - 2.1e-12 47.2 0.8 2.9e-12 46.7 0.8 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 ORX61865.1 - 8.9e-07 29.2 0.6 1.6e-06 28.4 0.6 1.4 1 0 0 1 1 1 1 HD domain TRI5 PF06330.11 ORX61865.1 - 0.0079 15.1 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Trichodiene synthase (TRI5) ABC_tran PF00005.27 ORX61866.1 - 1.3e-15 58.1 0.1 9.7e-15 55.3 0.1 2.1 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ORX61866.1 - 7.7e-08 32.5 0.4 0.0008 19.3 0.1 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ORX61866.1 - 1.4e-06 27.9 0.2 0.001 18.6 0.0 2.2 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ORX61866.1 - 0.00069 19.4 0.1 0.0084 15.9 0.0 2.0 1 1 0 2 2 2 1 AAA ATPase domain AAA_30 PF13604.6 ORX61866.1 - 0.0019 18.0 0.0 0.003 17.3 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ORX61866.1 - 0.0033 17.8 0.4 0.017 15.5 0.1 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ORX61866.1 - 0.0039 17.6 0.0 0.0057 17.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ORX61866.1 - 0.0054 17.3 0.1 0.011 16.2 0.1 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ORX61866.1 - 0.007 16.3 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_13 PF13166.6 ORX61866.1 - 0.01 14.5 0.0 0.019 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ORX61866.1 - 0.012 15.6 0.0 0.048 13.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ORX61866.1 - 0.014 15.3 0.0 0.036 14.0 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase SRP54 PF00448.22 ORX61866.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TsaE PF02367.17 ORX61866.1 - 0.016 15.2 0.0 0.03 14.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 ORX61866.1 - 0.048 13.4 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ORX61866.1 - 0.066 12.7 0.3 0.13 11.7 0.1 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 ORX61866.1 - 0.069 13.4 0.0 0.13 12.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ORX61866.1 - 0.1 13.0 0.0 1.5 9.2 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 ORX61866.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ORX61866.1 - 0.15 11.8 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX61866.1 - 0.2 11.9 0.0 0.38 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2370 PF10176.9 ORX61868.1 - 9.5e-69 231.5 1.3 5.7e-58 196.2 0.1 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF2370) Y_phosphatase2 PF03162.13 ORX61869.1 - 1.6e-54 184.0 0.0 2.6e-54 183.2 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX61869.1 - 2.3e-08 34.3 0.0 2.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ORX61869.1 - 0.00037 20.3 0.0 0.00083 19.2 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX61869.1 - 0.0008 19.0 0.0 0.0011 18.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase ADH_N PF08240.12 ORX61870.1 - 8.4e-11 41.7 0.0 2.3e-10 40.3 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX61870.1 - 9.7e-09 35.3 0.0 1.7e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX61870.1 - 0.00094 20.2 0.0 0.0019 19.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX61870.1 - 0.021 14.1 1.0 0.031 13.6 1.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TadZ_N PF16968.5 ORX61870.1 - 0.059 13.1 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Pilus assembly protein TadZ N-terminal JHD PF17811.1 ORX61871.1 - 2.6e-10 40.7 0.1 5.1e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 Jumonji helical domain JmjC PF02373.22 ORX61871.1 - 9.5e-10 38.9 1.6 1.9e-08 34.7 0.2 2.8 2 1 0 2 2 2 1 JmjC domain, hydroxylase PHD PF00628.29 ORX61871.1 - 2.5e-08 33.7 8.1 4.7e-08 32.8 8.1 1.5 1 0 0 1 1 1 1 PHD-finger Cupin_8 PF13621.6 ORX61871.1 - 9.8e-08 32.0 0.3 3.1e-07 30.4 0.3 1.8 1 1 0 1 1 1 1 Cupin-like domain C1_1 PF00130.22 ORX61871.1 - 0.0058 16.5 3.7 0.0058 16.5 3.7 2.0 1 1 1 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ORX61871.1 - 0.11 12.8 5.7 2.3 8.6 2.5 2.4 2 0 0 2 2 2 0 C1 domain Ribosomal_60s PF00428.19 ORX61872.1 - 9.6e-27 93.4 7.4 1.1e-26 93.2 7.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 ORX61872.1 - 0.032 14.7 2.5 0.059 13.8 0.3 2.0 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) zf-C2H2_2 PF12756.7 ORX61873.1 - 3.1e-31 107.7 12.1 6.9e-23 80.9 4.5 3.3 3 0 0 3 3 3 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX61873.1 - 5.6e-05 23.3 1.4 5.6e-05 23.3 1.4 2.6 3 0 0 3 3 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ORX61873.1 - 0.00033 21.2 19.5 0.0038 17.9 0.5 5.2 5 0 0 5 5 4 2 C2H2-type zinc finger zf-met PF12874.7 ORX61873.1 - 0.00039 20.7 0.7 0.00039 20.7 0.7 2.9 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ORX61873.1 - 0.0006 20.1 1.4 0.0006 20.1 1.4 4.8 5 0 0 5 5 5 1 Zinc finger, C2H2 type zf-BED PF02892.15 ORX61873.1 - 0.00085 19.3 4.0 0.013 15.5 0.6 3.6 3 0 0 3 3 3 1 BED zinc finger zf-C2H2_11 PF16622.5 ORX61873.1 - 0.0027 17.4 0.3 0.0027 17.4 0.3 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type PyrI_C PF02748.15 ORX61873.1 - 0.011 15.7 0.0 0.038 13.9 0.0 2.0 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_6 PF13912.6 ORX61873.1 - 0.045 13.8 1.2 0.16 12.0 1.2 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger FOXP-CC PF16159.5 ORX61873.1 - 1.8 9.3 13.6 8.8 7.0 0.1 4.9 5 1 1 6 6 6 0 FOXP coiled-coil domain zf-C2HE PF16278.5 ORX61873.1 - 4.3 7.9 8.0 5.4 7.5 0.5 3.0 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Haem_degrading PF03928.14 ORX61874.1 - 1.2e-24 86.6 0.6 1.5e-24 86.4 0.6 1.1 1 0 0 1 1 1 1 Haem-degrading VP7 PF00434.18 ORX61874.1 - 0.058 12.5 0.2 0.077 12.1 0.2 1.1 1 0 0 1 1 1 0 Glycoprotein VP7 Syntaxin_2 PF14523.6 ORX61875.1 - 5e-28 97.4 0.7 5e-28 97.4 0.7 2.8 3 0 0 3 3 3 1 Syntaxin-like protein SNARE PF05739.19 ORX61875.1 - 1.1e-11 44.5 1.1 1.1e-11 44.5 1.1 2.5 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 ORX61875.1 - 1.7e-07 31.1 11.8 1.7e-07 31.1 11.8 2.0 2 1 0 2 2 2 1 Syntaxin DUF5383 PF17355.2 ORX61875.1 - 0.065 13.6 0.2 0.065 13.6 0.2 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5383) PCDO_beta_N PF12391.8 ORX61875.1 - 0.16 11.6 0.0 0.32 10.6 0.0 1.5 1 0 0 1 1 1 0 Protocatechuate 3,4-dioxygenase beta subunit N terminal DUF4988 PF16378.5 ORX61875.1 - 0.25 11.0 5.0 5.8 6.6 0.5 2.8 2 1 1 3 3 3 0 Domain of unknown function DUF1664 PF07889.12 ORX61875.1 - 1.5 8.8 10.5 2.7 8.1 1.3 3.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 ORX61875.1 - 2 9.1 0.0 2 9.1 0.0 3.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) CEP209_CC5 PF16574.5 ORX61875.1 - 3 8.0 10.7 0.6 10.3 5.6 2.5 2 1 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 DUF4407 PF14362.6 ORX61875.1 - 5.7 6.2 12.1 1.4 8.2 6.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GCR1_C PF12550.8 ORX61876.1 - 2.4e-19 69.4 0.0 2.8e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Brix PF04427.18 ORX61877.1 - 2.5e-27 96.3 0.2 4.4e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Brix domain TBPIP_N PF15517.6 ORX61877.1 - 0.027 14.5 0.0 0.077 13.0 0.0 1.8 1 0 0 1 1 1 0 TBP-interacting protein N-terminus PIN_8 PF18476.1 ORX61877.1 - 2.3 8.0 9.7 3.1 7.6 5.1 2.1 2 0 0 2 2 2 0 PIN like domain Prenyltrans PF00432.21 ORX61878.1 - 1.3e-65 216.7 5.1 5.6e-14 51.6 0.1 6.0 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 ORX61878.1 - 1.8e-08 33.9 0.0 1.2e-05 24.6 0.0 2.6 2 1 1 3 3 3 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 ORX61878.1 - 4.3e-07 29.3 0.0 0.002 17.3 0.0 3.7 1 1 3 4 4 4 3 Squalene-hopene cyclase N-terminal domain TED_complement PF07678.14 ORX61878.1 - 0.0043 16.1 0.1 5.4 5.9 0.0 3.4 2 1 2 4 4 4 2 A-macroglobulin TED domain RRM_1 PF00076.22 ORX61879.1 - 3.2e-07 30.0 0.1 5.1e-06 26.2 0.0 2.5 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ORX61879.1 - 0.00012 22.0 7.1 0.0002 21.3 0.5 3.5 3 1 0 3 3 3 1 RNA binding motif PHM7_cyt PF14703.6 ORX61879.1 - 0.0057 16.9 6.1 4.2 7.6 0.0 4.1 3 1 0 4 4 4 2 Cytosolic domain of 10TM putative phosphate transporter TPP_enzyme_N PF02776.18 ORX61880.1 - 6.3e-51 172.4 0.6 6.6e-50 169.1 0.2 2.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 ORX61880.1 - 6.6e-36 123.1 0.0 1.2e-35 122.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 ORX61880.1 - 4e-27 94.9 0.0 3.2e-26 92.0 0.0 2.3 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 ORX61880.1 - 0.0036 16.6 0.0 0.0067 15.7 0.0 1.4 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_M_2 PF16582.5 ORX61880.1 - 0.022 14.5 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Middle domain of thiamine pyrophosphate ZnuA PF01297.17 ORX61880.1 - 0.05 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Cyclin_N PF00134.23 ORX61881.1 - 2.6e-10 40.2 0.1 3.7e-10 39.6 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 ORX61881.1 - 0.00032 21.1 0.8 0.00061 20.2 0.0 1.7 2 0 0 2 2 2 1 Cyclin GATA PF00320.27 ORX61882.1 - 1.4e-15 56.6 8.4 2.4e-15 55.8 8.4 1.4 1 0 0 1 1 1 1 GATA zinc finger Zn-ribbon_8 PF09723.10 ORX61882.1 - 0.0053 16.9 0.1 0.012 15.7 0.1 1.6 1 0 0 1 1 1 1 Zinc ribbon domain PAS_9 PF13426.7 ORX61882.1 - 0.0074 16.5 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 PAS domain DZR PF12773.7 ORX61882.1 - 0.024 14.7 0.3 0.098 12.7 0.4 1.9 1 1 0 1 1 1 0 Double zinc ribbon PAS PF00989.25 ORX61882.1 - 0.063 13.3 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 PAS fold SNF2_N PF00176.23 ORX61883.1 - 1.8e-72 244.0 1.8 1.8e-72 244.0 1.8 2.4 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ORX61883.1 - 8.2e-19 68.0 0.5 1.1e-17 64.3 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 ORX61883.1 - 5.9e-16 58.6 9.1 5.9e-16 58.6 9.1 3.1 4 0 0 4 4 4 1 HSA ResIII PF04851.15 ORX61883.1 - 8.8e-11 42.1 0.1 4.2e-10 39.9 0.0 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit SnAC PF14619.6 ORX61883.1 - 0.00033 21.2 0.2 0.00033 21.2 0.2 3.8 2 1 1 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex HDA2-3 PF11496.8 ORX61883.1 - 0.00044 19.5 0.2 0.00044 19.5 0.2 2.5 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 AAA_14 PF13173.6 ORX61883.1 - 0.16 12.0 2.1 0.4 10.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain HycH PF07450.11 ORX61885.1 - 0.085 13.2 0.2 0.36 11.2 0.1 1.9 1 1 0 2 2 2 0 Formate hydrogenlyase maturation protein HycH Drf_GBD PF06371.13 ORX61887.1 - 3.5e-15 56.1 0.0 6.5e-15 55.2 0.0 1.4 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain YL1 PF05764.13 ORX61887.1 - 5.8 7.0 9.1 12 6.0 9.1 1.4 1 0 0 1 1 1 0 YL1 nuclear protein FHA PF00498.26 ORX61889.1 - 1.4e-15 57.3 0.0 3.2e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX61889.1 - 7.3e-06 26.2 0.0 3.1e-05 24.2 0.0 1.9 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain ADH_N PF08240.12 ORX61890.1 - 8.2e-32 109.3 1.9 2e-31 108.1 1.9 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX61890.1 - 9.5e-19 67.7 0.1 1.5e-18 67.0 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 ORX61890.1 - 5.3e-08 32.6 1.3 1.3e-06 28.1 1.3 2.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ORX61890.1 - 8.8e-08 33.3 0.0 1.6e-07 32.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX61890.1 - 0.0049 16.2 0.0 0.011 15.0 0.0 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 ORX61890.1 - 0.021 14.4 0.1 0.072 12.7 0.0 1.9 1 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltransf_25 PF13649.6 ORX61890.1 - 0.03 15.0 0.0 0.059 14.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Pyr_redox_2 PF07992.14 ORX61890.1 - 0.069 12.4 0.7 0.16 11.2 0.1 2.0 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX61890.1 - 0.08 12.2 0.0 0.21 10.8 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Hexapep PF00132.24 ORX61890.1 - 0.1 12.4 0.4 16 5.4 0.1 2.9 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) ELFV_dehydrog PF00208.21 ORX61890.1 - 0.16 11.7 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Acetyltransf_1 PF00583.25 ORX61892.1 - 7.3e-19 68.1 0.0 9.2e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX61892.1 - 2.9e-09 36.9 0.0 3.5e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX61892.1 - 1.9e-08 34.6 0.0 2.8e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ORX61892.1 - 7.5e-05 22.8 0.0 0.00013 22.1 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 ORX61892.1 - 0.002 18.8 0.0 0.0025 18.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX61892.1 - 0.034 14.1 0.0 0.059 13.3 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein CTC1 PF15489.6 ORX61894.1 - 9.9e-12 43.2 0.1 4.6e-06 24.5 0.0 3.1 3 0 0 3 3 3 2 CST, telomere maintenance, complex subunit CTC1 adh_short_C2 PF13561.6 ORX61895.1 - 8e-68 228.5 0.1 9.4e-68 228.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX61895.1 - 6.2e-54 182.4 0.9 7.4e-54 182.2 0.4 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ORX61895.1 - 2.9e-17 63.2 0.2 3.9e-17 62.7 0.2 1.1 1 0 0 1 1 1 1 KR domain Glyco_hydro_1 PF00232.18 ORX61895.1 - 0.011 14.2 0.0 0.016 13.7 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 3HCDH_N PF02737.18 ORX61895.1 - 0.016 15.1 0.2 0.13 12.2 0.2 2.1 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Oxidored_nitro PF00148.19 ORX61895.1 - 0.045 12.5 0.4 0.1 11.3 0.4 1.6 1 1 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase OmdA PF13376.6 ORX61895.1 - 0.14 12.2 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated YAcAr PF10686.9 ORX61895.1 - 0.17 11.8 1.3 1.8 8.5 0.6 2.7 2 1 1 3 3 3 0 YspA, cpYpsA-related SLOG family Ribosomal_L31e PF01198.19 ORX61896.1 - 3.4e-39 133.0 0.9 4.3e-39 132.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e TrbC_Ftype PF09673.10 ORX61896.1 - 0.022 14.8 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Med17 PF10156.9 ORX61896.1 - 0.089 11.5 0.1 0.26 10.0 0.0 1.6 1 1 1 2 2 2 0 Subunit 17 of Mediator complex W2 PF02020.18 ORX61897.1 - 2.9e-21 75.4 0.6 7.9e-21 74.0 0.6 1.8 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 ORX61897.1 - 2.9e-12 45.8 12.9 3.9e-05 23.2 2.2 3.5 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 ORX61897.1 - 2.1e-07 30.8 0.0 3.5e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep_2 PF14602.6 ORX61897.1 - 0.0079 15.9 9.4 0.019 14.7 1.7 3.2 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 ORX61897.1 - 0.056 13.8 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain Fucokinase PF07959.12 ORX61897.1 - 0.18 10.7 2.6 0.6 9.0 1.9 1.9 1 1 1 2 2 2 0 L-fucokinase DUF4954 PF16314.5 ORX61897.1 - 0.53 8.4 4.6 2.4 6.2 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) Sec2p PF06428.11 ORX61898.1 - 1.1e-09 38.1 11.6 1.1e-09 38.1 11.6 2.5 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p DUF3108 PF11306.8 ORX61898.1 - 0.0097 15.9 0.1 0.026 14.5 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3108) Fez1 PF06818.15 ORX61898.1 - 0.025 15.0 16.9 0.41 11.1 17.5 2.2 1 1 1 2 2 2 0 Fez1 Atg14 PF10186.9 ORX61898.1 - 0.035 13.2 10.1 0.057 12.5 10.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Arteri_nucleo PF01481.16 ORX61898.1 - 2.5 8.4 6.2 0.58 10.5 0.5 2.2 2 0 0 2 2 2 0 Arterivirus nucleocapsid protein Spc7 PF08317.11 ORX61898.1 - 4.1 6.2 21.1 9.6 5.0 21.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF572 PF04502.13 ORX61898.1 - 4.4 6.8 12.0 7.6 6.0 12.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) AAA_13 PF13166.6 ORX61898.1 - 8.5 4.9 18.8 16 4.0 18.8 1.4 1 1 0 1 1 1 0 AAA domain Dynamitin PF04912.14 ORX61899.1 - 1.1e-85 288.3 23.7 1.3e-85 288.1 23.7 1.0 1 0 0 1 1 1 1 Dynamitin DUF1319 PF07028.11 ORX61899.1 - 0.001 19.3 2.9 0.0014 18.8 0.6 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1319) Osmo_CC PF08946.10 ORX61899.1 - 0.31 11.3 3.5 34 4.8 0.0 3.8 4 0 0 4 4 4 0 Osmosensory transporter coiled coil TPR_MLP1_2 PF07926.12 ORX61899.1 - 0.55 10.3 17.7 0.38 10.8 1.6 3.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Bap31 PF05529.12 ORX61900.1 - 1.3e-27 96.3 12.2 2.6e-24 85.6 2.5 2.2 1 1 1 2 2 2 2 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 ORX61900.1 - 2.7e-11 43.3 6.4 2.7e-11 43.3 6.4 2.1 1 1 1 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain Phage_GP20 PF06810.11 ORX61900.1 - 0.03 14.1 7.0 0.049 13.4 7.0 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 UbiA PF01040.18 ORX61900.1 - 0.034 13.5 0.4 0.042 13.2 0.4 1.1 1 0 0 1 1 1 0 UbiA prenyltransferase family HALZ PF02183.18 ORX61900.1 - 0.048 13.9 4.0 0.049 13.9 1.3 2.3 1 1 1 2 2 2 0 Homeobox associated leucine zipper Conotoxin PF02950.17 ORX61900.1 - 0.47 11.5 1.2 4.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Conotoxin DivIC PF04977.15 ORX61900.1 - 1.9 8.3 14.7 16 5.3 6.7 3.7 2 1 1 3 3 3 0 Septum formation initiator ZapB PF06005.12 ORX61900.1 - 2.1 8.9 9.2 0.46 10.9 4.0 2.4 2 1 1 3 3 3 0 Cell division protein ZapB DUF4577 PF15145.6 ORX61900.1 - 3.9 7.5 10.7 5.2 7.1 5.9 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4577) Prefoldin PF02996.17 ORX61901.1 - 1.5e-27 95.8 2.3 2.1e-27 95.4 2.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin_3 PF13758.6 ORX61901.1 - 0.00017 21.6 0.3 0.00035 20.6 0.3 1.6 1 1 0 1 1 1 1 Prefoldin subunit MitMem_reg PF13012.6 ORX61901.1 - 0.0038 17.6 1.9 0.045 14.2 0.1 2.0 1 1 1 2 2 2 1 Maintenance of mitochondrial structure and function Prefoldin_2 PF01920.20 ORX61901.1 - 0.0061 16.5 6.8 0.23 11.5 2.7 2.3 2 0 0 2 2 2 2 Prefoldin subunit DUF883 PF05957.13 ORX61901.1 - 0.016 15.8 2.5 0.75 10.4 0.6 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) KapB PF08810.10 ORX61901.1 - 0.095 12.9 4.3 0.082 13.1 1.8 2.0 2 0 0 2 2 2 0 Kinase associated protein B Fib_alpha PF08702.10 ORX61901.1 - 0.14 12.3 4.9 0.31 11.2 1.5 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FadA PF09403.10 ORX61901.1 - 0.16 12.4 9.2 0.96 10.0 1.0 2.6 2 1 0 2 2 2 0 Adhesion protein FadA ApoO PF09769.9 ORX61901.1 - 0.17 11.8 0.8 6.4 6.7 0.3 2.6 2 1 1 3 3 3 0 Apolipoprotein O DUF5082 PF16888.5 ORX61901.1 - 0.19 12.0 6.7 5.7 7.2 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 ORX61901.1 - 0.22 11.7 6.9 0.8 9.9 0.4 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 ORX61901.1 - 0.24 11.4 4.9 2.8 8.0 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Latarcin PF10279.9 ORX61901.1 - 0.26 11.7 4.4 0.5 10.8 0.2 2.4 2 1 0 2 2 2 0 Latarcin precursor Spc7 PF08317.11 ORX61901.1 - 0.46 9.3 9.5 0.38 9.6 0.6 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein TRPM_tetra PF16519.5 ORX61901.1 - 0.5 10.5 3.6 1.4 9.1 0.1 2.9 3 1 0 3 3 3 0 Tetramerisation domain of TRPM CC2-LZ PF16516.5 ORX61901.1 - 0.87 10.0 8.9 1.8 8.9 3.3 2.3 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator GIT_CC PF16559.5 ORX61901.1 - 3.7 7.5 12.4 1.7 8.6 1.8 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FH2 PF02181.23 ORX61902.1 - 1.7e-77 261.1 11.0 1.7e-77 261.1 11.0 3.1 2 2 1 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 ORX61902.1 - 2.9e-45 154.2 1.4 2.9e-45 154.2 1.4 2.5 4 0 0 4 4 4 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ORX61902.1 - 1e-38 132.9 1.2 1e-38 132.9 1.2 3.7 2 2 1 3 3 3 1 Diaphanous FH3 Domain Drf_DAD PF06345.11 ORX61902.1 - 0.15 12.1 0.0 0.49 10.5 0.0 1.8 1 0 0 1 1 1 0 DRF Autoregulatory Domain Pro_Al_protease PF02983.14 ORX61902.1 - 1.2 9.2 7.8 19 5.4 0.1 4.5 4 0 0 4 4 4 0 Alpha-lytic protease prodomain ZapB PF06005.12 ORX61902.1 - 1.6 9.2 23.7 0.12 12.8 1.8 4.6 4 0 0 4 4 4 0 Cell division protein ZapB eIF3_p135 PF12807.7 ORX61902.1 - 4.9 7.1 6.6 0.37 10.8 0.1 2.5 3 0 0 3 3 3 0 Translation initiation factor eIF3 subunit 135 Sec16_C PF12931.7 ORX61903.1 - 5e-54 184.0 0.7 7.1e-54 183.5 0.7 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 DUF2373 PF10180.9 ORX61904.1 - 0.42 10.5 2.4 1.3 8.9 2.4 1.8 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) SWIRM PF04433.17 ORX61906.1 - 8.5e-29 99.7 0.0 2e-28 98.6 0.0 1.7 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 ORX61906.1 - 7.6e-24 83.5 7.1 1.6e-23 82.4 7.1 1.6 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 ORX61906.1 - 6.4e-11 42.3 0.0 1.5e-10 41.1 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX61906.1 - 8.1e-07 29.2 0.0 1.9e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ORX61906.1 - 0.001 18.8 5.6 0.0019 18.0 5.6 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type SANT_DAMP1_like PF16282.5 ORX61906.1 - 0.057 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-bind_7 PF15963.5 ORX61906.1 - 0.12 12.2 0.3 0.43 10.5 0.0 2.0 2 0 0 2 2 2 0 Myb DNA-binding like BIRC6 PF12356.8 ORX61907.1 - 0.34 10.3 2.6 0.57 9.6 2.6 1.4 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 zf-C2H2 PF00096.26 ORX61909.1 - 6.7e-11 42.0 14.1 7.3e-06 26.2 1.5 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX61909.1 - 1.8e-09 37.6 17.9 5.7e-08 32.8 2.5 3.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX61909.1 - 7.1e-08 32.7 12.7 0.00012 22.6 1.2 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX61909.1 - 3.9e-05 23.5 9.7 0.0024 17.8 2.0 2.3 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX61909.1 - 8.6e-05 22.7 3.1 0.032 14.5 0.2 2.2 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 ORX61909.1 - 0.0073 16.6 3.4 0.022 15.0 3.4 1.8 1 1 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 ORX61909.1 - 0.0097 16.2 4.0 0.89 9.9 0.2 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 ORX61909.1 - 0.014 15.4 5.5 2.5 8.2 3.6 2.3 1 1 1 2 2 2 0 BED zinc finger Zn-ribbon_8 PF09723.10 ORX61909.1 - 0.065 13.4 6.1 1.5 9.0 0.4 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Ogr_Delta PF04606.12 ORX61909.1 - 0.067 13.2 2.5 0.17 11.9 2.5 1.8 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.7 ORX61909.1 - 0.15 12.1 4.5 0.49 10.4 4.5 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-C2HC_2 PF13913.6 ORX61909.1 - 0.16 11.9 0.2 0.16 11.9 0.2 2.4 2 1 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2_11 PF16622.5 ORX61909.1 - 0.26 11.1 6.3 0.88 9.4 0.9 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type Adenylsucc_synt PF00709.21 ORX61910.1 - 1.5e-178 594.1 0.0 1.7e-178 593.9 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase RIBIOP_C PF04950.12 ORX61911.1 - 2e-92 309.8 0.0 2e-92 309.8 0.0 2.2 2 0 0 2 2 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ORX61911.1 - 8.8e-32 109.0 0.0 4.4e-31 106.8 0.0 2.3 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_22 PF13401.6 ORX61911.1 - 3.5e-06 27.3 0.0 1.6e-05 25.2 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ORX61911.1 - 3.2e-05 24.4 0.0 0.00013 22.4 0.0 2.0 1 0 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 ORX61911.1 - 5.7e-05 23.3 0.2 0.00035 20.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain GTP_EFTU PF00009.27 ORX61911.1 - 0.00013 21.6 0.0 0.043 13.3 0.0 2.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA PF00004.29 ORX61911.1 - 0.00044 20.7 0.0 0.002 18.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ORX61911.1 - 0.00054 20.0 0.4 0.0032 17.5 0.1 2.6 2 1 0 2 2 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ORX61911.1 - 0.0019 18.7 0.0 0.0019 18.7 0.0 3.1 4 0 0 4 4 3 1 ABC transporter AAA_30 PF13604.6 ORX61911.1 - 0.0048 16.6 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ORX61911.1 - 0.0094 15.6 0.0 0.024 14.2 0.0 1.7 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ORX61911.1 - 0.011 16.1 0.0 0.051 14.0 0.0 2.2 2 0 0 2 2 1 0 RNA helicase AAA_18 PF13238.6 ORX61911.1 - 0.011 16.2 0.0 0.011 16.2 0.0 3.5 4 1 0 4 4 3 0 AAA domain NACHT PF05729.12 ORX61911.1 - 0.014 15.3 0.0 0.032 14.2 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 ORX61911.1 - 0.02 15.1 0.5 0.13 12.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ORX61911.1 - 0.023 14.4 0.0 0.059 13.1 0.0 1.6 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Ploopntkinase3 PF18751.1 ORX61911.1 - 0.025 14.5 2.1 0.039 13.9 0.0 2.3 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 Zeta_toxin PF06414.12 ORX61911.1 - 0.03 13.6 0.0 0.03 13.6 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 ORX61911.1 - 0.035 14.4 0.4 0.099 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ORX61911.1 - 0.042 13.0 0.0 0.097 11.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain ATP_bind_1 PF03029.17 ORX61911.1 - 0.05 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 ORX61911.1 - 0.052 13.3 0.0 0.15 11.8 0.0 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NTPase_1 PF03266.15 ORX61911.1 - 0.06 13.3 0.1 0.15 11.9 0.1 1.7 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 ORX61911.1 - 0.075 13.0 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ORX61911.1 - 0.082 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.6 ORX61911.1 - 0.12 12.8 0.0 0.12 12.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain ATPase_2 PF01637.18 ORX61911.1 - 0.21 11.5 0.0 0.21 11.5 0.0 2.5 3 0 0 3 3 1 0 ATPase domain predominantly from Archaea MFS_1 PF07690.16 ORX61912.1 - 2.7e-27 95.6 69.2 2.3e-19 69.6 37.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TIL PF01826.17 ORX61914.1 - 6.4 7.1 26.0 9.8e+02 0.1 26.0 2.5 1 1 0 1 1 1 0 Trypsin Inhibitor like cysteine rich domain ArfGap PF01412.18 ORX61915.1 - 1.1e-35 122.2 0.0 2.7e-35 121.0 0.0 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf DLIC PF05783.11 ORX61915.1 - 7.1 5.3 9.0 2.3 6.9 1.4 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) Methyltransf_11 PF08241.12 ORX61916.1 - 5.2e-16 59.1 0.0 8.8e-16 58.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX61916.1 - 1e-12 48.6 0.0 2.9e-12 47.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX61916.1 - 9.4e-10 38.6 0.0 1.2e-09 38.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX61916.1 - 2.8e-07 31.2 0.0 5e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ORX61916.1 - 3.6e-06 26.6 0.1 9.3e-06 25.3 0.0 1.7 2 1 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ORX61916.1 - 3.2e-05 23.4 0.0 6.1e-05 22.5 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 ORX61916.1 - 9.4e-05 22.3 0.0 0.00017 21.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX61916.1 - 0.0027 17.0 0.5 0.0084 15.4 0.5 1.7 1 1 0 1 1 1 1 O-methyltransferase domain MetW PF07021.12 ORX61916.1 - 0.0083 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 ORX61916.1 - 0.04 13.8 0.0 0.093 12.6 0.0 1.7 1 1 0 1 1 1 0 Hypothetical methyltransferase DREV PF05219.12 ORX61916.1 - 0.067 12.3 0.0 0.087 11.9 0.0 1.1 1 0 0 1 1 1 0 DREV methyltransferase RrnaAD PF00398.20 ORX61916.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PCMT PF01135.19 ORX61916.1 - 0.19 11.5 0.2 0.63 9.7 0.2 1.9 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF3808 PF10300.9 ORX61918.1 - 4e-95 319.3 2.0 6.4e-95 318.6 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_14 PF13428.6 ORX61918.1 - 0.00028 21.4 2.2 5.5 8.1 0.1 4.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX61918.1 - 0.0013 18.7 4.8 0.35 11.1 0.1 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ORX61918.1 - 0.0036 17.9 0.2 0.38 11.5 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF4805 PF16063.5 ORX61918.1 - 0.0039 16.6 0.3 0.0069 15.7 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) TPR_19 PF14559.6 ORX61918.1 - 0.03 14.8 3.0 4.1 8.0 0.0 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat Peptidase_M16_C PF05193.21 ORX61918.1 - 0.085 12.9 0.3 11 6.0 0.0 3.6 3 1 0 3 3 3 0 Peptidase M16 inactive domain TPR_12 PF13424.6 ORX61918.1 - 1 9.7 8.6 3.6 8.0 0.9 4.2 4 1 1 5 5 5 0 Tetratricopeptide repeat RGS PF00615.19 ORX61919.1 - 7.4e-25 87.5 0.2 1.3e-24 86.7 0.2 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DEP PF00610.21 ORX61919.1 - 3.2e-14 52.7 0.6 1.5e-09 37.8 0.1 3.5 4 0 0 4 4 4 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PA PF02225.22 ORX61920.1 - 8.8e-07 28.9 0.0 1.4e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 PA domain Pkinase PF00069.25 ORX61921.1 - 8.7e-54 182.6 0.0 7.3e-53 179.6 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61921.1 - 7.6e-28 97.5 0.0 3.8e-25 88.6 0.0 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61921.1 - 2.8e-06 26.9 0.0 5.5e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX61921.1 - 0.013 14.3 0.0 0.028 13.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Suc_Fer-like PF06999.12 ORX61922.1 - 2.7e-62 210.1 0.0 3.2e-62 209.9 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like adh_short PF00106.25 ORX61923.1 - 7.1e-45 152.9 2.7 9.6e-45 152.4 2.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX61923.1 - 5.5e-32 111.2 1.3 7e-32 110.8 1.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX61923.1 - 1.4e-05 25.1 1.8 2.6e-05 24.2 1.0 1.9 2 1 0 2 2 2 1 KR domain Epimerase PF01370.21 ORX61923.1 - 0.00019 21.0 0.1 0.00032 20.2 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX61923.1 - 0.03 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Pertussis_S2S3 PF02918.15 ORX61923.1 - 0.084 12.8 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 Pertussis toxin, subunit 2 and 3, C-terminal domain adh_short PF00106.25 ORX61924.1 - 1.7e-48 164.7 0.1 2.3e-48 164.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX61924.1 - 3.9e-34 118.2 0.1 4.9e-34 117.9 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX61924.1 - 1.3e-06 28.4 0.0 2.6e-06 27.5 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ORX61924.1 - 4.4e-05 23.1 0.0 9.9e-05 21.9 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 ORX61924.1 - 0.00011 21.7 0.0 0.005 16.3 0.0 2.1 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 ORX61924.1 - 0.038 13.4 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ORX61924.1 - 0.085 11.9 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain zf-C2H2_4 PF13894.6 ORX61927.1 - 1.3e-05 25.6 8.7 0.021 15.6 0.4 2.6 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 ORX61927.1 - 0.00017 21.8 2.4 0.014 15.5 0.3 2.0 1 1 1 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ORX61927.1 - 0.00029 21.1 5.7 0.12 12.9 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type FOXP-CC PF16159.5 ORX61927.1 - 0.0055 17.3 1.4 0.75 10.5 0.1 2.2 2 0 0 2 2 2 2 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 ORX61927.1 - 0.019 15.3 6.0 1.1 9.6 6.2 2.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF4729 PF15866.5 ORX61927.1 - 0.033 13.5 1.4 0.033 13.5 1.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4729) DUF629 PF04780.12 ORX61927.1 - 0.14 10.7 1.5 1.2 7.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF629) Med6 PF04934.14 ORX61928.1 - 1.8e-37 128.1 0.4 2e-37 127.9 0.4 1.0 1 0 0 1 1 1 1 MED6 mediator sub complex component F-box PF00646.33 ORX61929.1 - 0.037 13.9 0.0 0.15 12.0 0.0 2.1 1 0 0 1 1 1 0 F-box domain F-box-like PF12937.7 ORX61930.1 - 0.00025 20.9 2.6 0.0013 18.6 0.0 3.0 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ORX61930.1 - 0.0037 17.1 0.0 0.02 14.8 0.0 2.4 1 0 0 1 1 1 1 F-box domain RhoGAP PF00620.27 ORX61931.1 - 4.2e-12 46.1 2.7 4.7e-12 46.0 0.5 2.3 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 ORX61931.1 - 7.2e-05 23.0 0.0 0.00025 21.3 0.0 2.1 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain SR-25 PF10500.9 ORX61931.1 - 9.4 5.8 15.4 6.9 6.2 3.6 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RCC1 PF00415.18 ORX61932.1 - 1.6e-20 73.4 0.5 1.2e-06 29.0 0.2 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX61932.1 - 1e-07 31.5 6.5 0.00073 19.3 0.7 4.8 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat sCache_3_2 PF17203.4 ORX61932.1 - 0.16 12.1 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Single cache domain 3 Mit_ribos_Mrp51 PF11709.8 ORX61933.1 - 5e-13 49.4 5.1 2.1e-09 37.4 0.8 3.5 3 1 0 3 3 3 2 Mitochondrial ribosomal protein subunit DEAD PF00270.29 ORX61934.1 - 7.8e-42 143.0 0.0 1.4e-41 142.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX61934.1 - 4.2e-24 85.0 0.0 9.5e-23 80.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ORX61934.1 - 1.1e-16 60.7 0.1 2.3e-16 59.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 ORX61934.1 - 2.8e-06 27.4 0.0 9.1e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ORX61934.1 - 0.028 13.6 0.0 0.14 11.3 0.0 2.0 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 ORX61934.1 - 0.076 13.3 1.3 0.34 11.2 0.4 2.5 2 1 0 2 2 2 0 AAA domain Ecl1 PF12855.7 ORX61935.1 - 2e-12 48.6 5.3 2.2e-12 48.5 5.3 1.0 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 ORX61935.1 - 0.035 14.2 6.7 0.52 10.5 6.7 2.1 1 1 0 1 1 1 0 MYND finger SMN PF06003.12 ORX61935.1 - 0.13 11.5 0.8 0.15 11.3 0.8 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) zf-C6H2 PF15801.5 ORX61935.1 - 0.26 11.6 4.2 0.39 11.0 4.2 1.2 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding zf-C2H2_jaz PF12171.8 ORX61935.1 - 1.7 9.0 6.5 4.4 7.7 3.8 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding NAC PF01849.18 ORX61936.1 - 6.5e-23 80.5 0.0 1.1e-22 79.7 0.0 1.4 1 0 0 1 1 1 1 NAC domain Melibiase PF02065.18 ORX61938.1 - 4.3e-15 55.5 0.2 7e-15 54.8 0.2 1.2 1 0 0 1 1 1 1 Melibiase Glyco_hydro_31 PF01055.26 ORX61938.1 - 4.1e-07 29.6 0.1 6.1e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Melibiase_2 PF16499.5 ORX61938.1 - 0.0011 18.2 0.1 1.2 8.3 0.0 2.3 2 0 0 2 2 2 2 Alpha galactosidase A Raffinose_syn PF05691.12 ORX61938.1 - 0.0053 14.6 0.1 0.0081 14.0 0.1 1.1 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 DNA_pol_B_palm PF14792.6 ORX61939.1 - 1.4e-23 83.3 0.0 2.5e-23 82.4 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 ORX61939.1 - 4.2e-17 61.7 0.1 1e-16 60.4 0.1 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_thumb PF14791.6 ORX61939.1 - 9.4e-17 61.0 0.1 1.9e-16 60.0 0.1 1.6 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 ORX61939.1 - 7e-10 39.1 0.0 3.2e-09 37.0 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 ORX61939.1 - 0.00094 19.4 0.0 0.0022 18.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain HHH_5 PF14520.6 ORX61939.1 - 0.01 16.4 0.0 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain MG3 PF17791.1 ORX61939.1 - 0.077 13.3 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 Macroglobulin domain MG3 DUF3701 PF12482.8 ORX61939.1 - 0.11 12.6 0.1 7.7 6.7 0.0 3.0 2 1 1 3 3 3 0 Phage integrase protein Alg6_Alg8 PF03155.15 ORX61940.1 - 1.4e-139 466.2 31.3 2e-139 465.7 31.3 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ku PF02735.16 ORX61941.1 - 1.4e-44 152.2 0.0 2.6e-44 151.4 0.0 1.4 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ORX61941.1 - 2.9e-39 135.1 0.1 4e-39 134.6 0.1 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ORX61941.1 - 6.3e-09 36.4 0.4 2e-08 34.8 0.1 2.0 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm Arrestin_N PF00339.29 ORX61942.1 - 8.3e-18 64.8 0.0 2.1e-17 63.6 0.0 1.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Rgp1 PF08737.10 ORX61942.1 - 0.022 14.0 0.9 0.032 13.4 0.1 1.6 2 0 0 2 2 2 0 Rgp1 Malic_M PF03949.15 ORX61943.1 - 5.5e-82 274.9 0.3 7.2e-82 274.5 0.3 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 ORX61943.1 - 5.9e-59 198.9 0.0 1.2e-58 198.0 0.0 1.5 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Borrelia_lipo_1 PF05714.11 ORX61943.1 - 0.057 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Borrelia burgdorferi virulent strain associated lipoprotein Thg1 PF04446.12 ORX61943.1 - 0.1 12.7 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 tRNAHis guanylyltransferase GEN1_C PF18380.1 ORX61944.1 - 8.7 7.3 6.8 1.3 10.0 0.1 2.5 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain LSM PF01423.22 ORX61945.1 - 1.5e-18 66.2 0.4 1.9e-18 65.9 0.4 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_S8 PF00410.19 ORX61946.1 - 6.5e-19 68.1 0.0 5.5e-18 65.1 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8 Y_phosphatase PF00102.27 ORX61948.1 - 6.9e-66 222.2 2.1 1.4e-65 221.2 2.1 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 ORX61948.1 - 3.8e-11 43.5 0.0 1e-10 42.1 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 ORX61948.1 - 0.0071 16.3 0.0 0.048 13.6 0.0 2.1 2 0 0 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 ORX61948.1 - 0.018 14.8 0.1 0.046 13.5 0.1 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain AbiEi_2 PF09952.9 ORX61948.1 - 0.047 13.9 0.0 0.088 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system DUF1682 PF07946.14 ORX61949.1 - 4.5 6.4 9.3 1.6 7.8 6.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Mannosyl_trans3 PF11051.8 ORX61950.1 - 2.3e-28 99.3 0.0 1.5e-19 70.5 0.0 2.1 2 0 0 2 2 2 2 Mannosyltransferase putative SAM_2 PF07647.17 ORX61951.1 - 1.5e-07 31.4 0.0 4e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ORX61951.1 - 0.001 19.5 0.1 0.0019 18.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DNA_ligase_A_N PF04675.14 ORX61951.1 - 0.068 13.5 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 DNA ligase N terminus Pkinase PF00069.25 ORX61952.1 - 1.1e-73 247.9 0.0 1.3e-73 247.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX61952.1 - 5.1e-37 127.6 0.0 6.5e-37 127.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX61952.1 - 5.7e-07 29.1 0.1 1.5e-06 27.7 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX61952.1 - 0.077 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX61952.1 - 0.1 12.5 0.0 0.21 11.5 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Amidase PF01425.21 ORX61954.1 - 1.9e-70 238.1 0.3 2.6e-70 237.6 0.3 1.2 1 0 0 1 1 1 1 Amidase PPR_2 PF13041.6 ORX61955.1 - 1.1e-42 144.0 10.1 1.9e-08 34.4 0.2 8.3 7 2 3 10 10 10 8 PPR repeat family PPR_3 PF13812.6 ORX61955.1 - 1.7e-30 104.9 4.1 9.7e-11 41.6 0.1 7.4 7 1 1 8 8 8 4 Pentatricopeptide repeat domain PPR PF01535.20 ORX61955.1 - 2.7e-18 64.8 7.2 0.00051 20.1 0.0 9.9 11 0 0 11 11 11 5 PPR repeat PPR_long PF17177.4 ORX61955.1 - 6.9e-15 55.0 5.3 3e-08 33.3 0.2 4.5 2 1 1 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ORX61955.1 - 1.5e-09 37.3 10.9 0.12 12.1 0.1 8.5 10 0 0 10 10 10 4 PPR repeat RPM2 PF08579.11 ORX61955.1 - 0.00042 20.7 8.6 0.93 9.9 0.1 5.8 5 1 2 7 7 7 2 Mitochondrial ribonuclease P subunit (RPM2) TPR_14 PF13428.6 ORX61955.1 - 0.0019 18.9 2.7 9.8 7.3 0.0 5.6 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF4003 PF13170.6 ORX61955.1 - 0.0022 17.4 1.3 0.14 11.5 0.1 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF4003) AEP1 PF17049.5 ORX61955.1 - 0.0069 15.5 0.1 0.019 14.1 0.1 1.9 1 0 0 1 1 1 1 ATPase expression protein 1 RCC1 PF00415.18 ORX61957.1 - 1.5e-22 80.0 7.5 2.2e-06 28.2 0.0 5.2 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX61957.1 - 8.7e-15 54.1 28.0 1.8e-05 24.4 1.3 6.9 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 ORX61957.1 - 1.2e-06 28.3 0.3 2.7e-06 27.2 0.3 1.7 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ORX61957.1 - 5.7e-05 23.0 0.1 0.00011 22.0 0.1 1.5 1 0 0 1 1 1 1 F-box F-box PF00646.33 ORX61957.1 - 0.00035 20.4 0.1 0.00074 19.3 0.1 1.6 1 0 0 1 1 1 1 F-box domain Kelch_2 PF07646.15 ORX61957.1 - 0.41 10.7 4.7 0.58 10.2 0.2 3.0 3 0 0 3 3 3 0 Kelch motif Amidase PF01425.21 ORX61958.1 - 2.9e-85 286.9 0.1 7.9e-85 285.5 0.1 1.6 1 1 0 1 1 1 1 Amidase Amidase PF01425.21 ORX61959.1 - 1.4e-85 288.0 0.1 3.9e-85 286.5 0.1 1.7 1 1 0 1 1 1 1 Amidase Abhydrolase_1 PF00561.20 ORX61960.1 - 3.2e-22 79.4 0.2 1.5e-21 77.2 0.2 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX61960.1 - 1.9e-17 63.3 0.1 4.8e-17 62.0 0.1 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX61960.1 - 5.4e-16 59.9 1.0 7.9e-16 59.3 0.4 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 ORX61960.1 - 0.00066 19.3 1.2 0.086 12.4 0.0 3.0 3 1 0 3 3 3 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 ORX61960.1 - 0.00086 19.1 0.1 0.28 11.0 0.0 3.0 3 0 0 3 3 3 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ORX61960.1 - 0.014 15.2 0.0 0.062 13.1 0.0 2.0 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 ORX61960.1 - 0.015 15.0 0.0 0.05 13.3 0.0 1.8 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_4 PF08386.10 ORX61960.1 - 0.046 13.8 0.0 0.075 13.2 0.0 1.3 1 0 0 1 1 1 0 TAP-like protein Esterase_phd PF10503.9 ORX61960.1 - 0.16 11.5 0.5 12 5.3 0.1 2.5 3 0 0 3 3 3 0 Esterase PHB depolymerase AAA_6 PF12774.7 ORX61965.1 - 5.7e-132 439.6 0.1 8.1e-130 432.6 0.0 3.5 2 1 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N1 PF08385.12 ORX61965.1 - 2.3e-122 409.5 10.9 2.3e-122 409.5 10.9 3.4 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 ORX61965.1 - 5.8e-121 404.3 6.6 5.8e-121 404.3 6.6 6.5 6 2 1 7 7 6 1 Dynein heavy chain, N-terminal region 2 AAA_9 PF12781.7 ORX61965.1 - 5.8e-76 254.5 0.1 5.8e-76 254.5 0.1 4.3 4 1 0 4 4 4 1 ATP-binding dynein motor region AAA_8 PF12780.7 ORX61965.1 - 6e-69 232.3 0.0 1.2e-67 227.9 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 Dynein_C PF18199.1 ORX61965.1 - 2.6e-46 158.3 0.5 7.8e-46 156.7 0.5 1.9 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain MT PF12777.7 ORX61965.1 - 6.1e-44 150.5 8.4 6.1e-44 150.5 8.4 1.7 2 0 0 2 2 1 1 Microtubule-binding stalk of dynein motor AAA_7 PF12775.7 ORX61965.1 - 1.2e-41 142.2 0.0 4.4e-35 120.8 0.0 5.1 6 0 0 6 6 5 2 P-loop containing dynein motor region AAA_lid_11 PF18198.1 ORX61965.1 - 1.5e-37 129.0 0.0 3.3e-37 127.8 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ORX61965.1 - 2.5e-31 108.2 0.0 2.3e-28 98.7 0.0 4.1 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_5 PF07728.14 ORX61965.1 - 8.1e-31 106.9 0.0 5e-13 49.2 0.0 6.0 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 ORX61965.1 - 7.8e-18 64.8 0.0 3.7e-17 62.6 0.0 2.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 ORX61965.1 - 3.1e-15 56.7 0.3 0.0037 17.5 0.0 6.1 5 0 0 5 5 5 3 AAA domain AAA PF00004.29 ORX61965.1 - 2.1e-12 47.6 0.0 0.014 15.9 0.0 5.1 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ORX61965.1 - 3.3e-11 43.5 0.4 0.06 13.5 0.0 5.9 6 0 0 6 6 5 3 AAA domain AAA_16 PF13191.6 ORX61965.1 - 8.5e-09 36.0 0.0 0.72 10.2 0.0 6.3 6 0 0 6 6 5 2 AAA ATPase domain AAA_18 PF13238.6 ORX61965.1 - 1.2e-08 35.6 0.0 0.16 12.5 0.0 5.5 4 0 0 4 4 4 2 AAA domain AAA_lid_1 PF17857.1 ORX61965.1 - 1.7e-06 28.2 1.8 5.5e-06 26.5 0.0 2.9 3 0 0 3 3 1 1 AAA+ lid domain FtsK_SpoIIIE PF01580.18 ORX61965.1 - 2.4e-06 27.1 0.0 0.68 9.2 0.0 4.7 5 0 0 5 5 5 2 FtsK/SpoIIIE family Mg_chelatase PF01078.21 ORX61965.1 - 5.2e-06 26.0 0.4 0.77 9.1 0.0 3.8 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 ORX61965.1 - 5.3e-06 25.7 0.0 0.029 13.4 0.0 3.9 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_29 PF13555.6 ORX61965.1 - 3.6e-05 23.4 0.1 0.7 9.7 0.0 3.6 3 0 0 3 3 3 2 P-loop containing region of AAA domain ABC_tran PF00005.27 ORX61965.1 - 0.00013 22.5 0.0 5.9 7.4 0.0 4.7 3 0 0 3 3 3 0 ABC transporter AAA_30 PF13604.6 ORX61965.1 - 0.00014 21.6 0.5 18 5.0 0.0 4.5 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 ORX61965.1 - 0.00059 20.2 2.2 0.31 11.4 0.0 4.7 5 0 0 5 5 4 1 AAA domain IstB_IS21 PF01695.17 ORX61965.1 - 0.00095 18.9 1.2 0.55 9.9 0.0 4.6 5 0 0 5 5 4 1 IstB-like ATP binding protein Rad17 PF03215.15 ORX61965.1 - 0.0031 17.5 0.0 34 4.3 0.0 4.1 4 0 0 4 4 4 0 Rad17 P-loop domain AAA_24 PF13479.6 ORX61965.1 - 0.0039 16.9 0.8 57 3.4 0.0 5.1 5 0 0 5 5 4 0 AAA domain RNA_helicase PF00910.22 ORX61965.1 - 0.005 17.2 0.0 6 7.3 0.0 4.5 4 0 0 4 4 4 0 RNA helicase AAA_25 PF13481.6 ORX61965.1 - 0.011 15.3 0.0 0.49 10.0 0.0 3.4 3 0 0 3 3 2 0 AAA domain DUF390 PF04094.14 ORX61965.1 - 0.035 12.4 5.0 0.056 11.7 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF390) NACHT PF05729.12 ORX61965.1 - 0.043 13.7 0.8 53 3.7 0.0 4.4 4 0 0 4 4 3 0 NACHT domain DUF3808 PF10300.9 ORX61966.1 - 6.5e-50 170.2 5.8 1e-49 169.6 5.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_2 PF07719.17 ORX61966.1 - 0.00095 19.1 0.8 13 6.2 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ERbeta_N PF12497.8 ORX61966.1 - 0.0028 17.4 0.2 0.013 15.2 0.2 2.2 2 0 0 2 2 2 1 Estrogen receptor beta TPR_16 PF13432.6 ORX61966.1 - 0.023 15.3 0.1 17 6.1 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX61966.1 - 0.1 12.5 0.1 54 3.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_4 PF07721.14 ORX61966.1 - 1.7 9.5 4.6 32 5.5 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Tubulin PF00091.25 ORX61967.1 - 5.5e-67 225.8 0.0 7.7e-67 225.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX61967.1 - 1.3e-49 167.6 0.0 2e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ORX61967.1 - 0.00082 19.1 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Prefoldin PF02996.17 ORX61968.1 - 7.8e-14 51.6 0.1 2e-13 50.3 0.1 1.7 1 0 0 1 1 1 1 Prefoldin subunit DUF3835 PF12927.7 ORX61968.1 - 6.2e-08 33.4 24.6 4.5e-07 30.6 8.5 5.6 4 2 1 5 5 5 2 Domain of unknown function (DUF3835) Prefoldin_3 PF13758.6 ORX61968.1 - 0.0016 18.5 0.0 0.0065 16.5 0.0 2.2 1 0 0 1 1 1 1 Prefoldin subunit FliD_N PF02465.18 ORX61968.1 - 0.35 11.6 2.5 0.6 10.8 0.1 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus SRF-TF PF00319.18 ORX61969.1 - 3.8e-22 77.5 0.1 5.8e-22 76.9 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Trp_syntA PF00290.20 ORX61971.1 - 2.5e-93 311.7 0.1 4.5e-93 310.8 0.1 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 ORX61971.1 - 1.2e-45 156.2 0.5 1.9e-45 155.5 0.5 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Pyr_redox_2 PF07992.14 ORX61974.1 - 1.9e-48 165.2 0.3 2.1e-48 165.0 0.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX61974.1 - 3.7e-19 69.1 0.3 2.3e-16 59.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX61974.1 - 1.2e-15 57.8 0.6 1.8e-13 50.8 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ORX61974.1 - 2.2e-07 30.3 0.7 0.0052 15.9 0.0 3.7 3 1 1 4 4 4 2 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ORX61974.1 - 3.9e-05 23.8 0.2 0.018 15.2 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 ORX61974.1 - 7.4e-05 22.3 0.1 0.017 14.5 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 ORX61974.1 - 0.00013 21.2 0.3 0.54 9.4 0.0 3.7 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_7 PF13241.6 ORX61974.1 - 0.00014 22.2 0.1 0.027 14.9 0.0 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding Thi4 PF01946.17 ORX61974.1 - 0.00016 21.0 0.2 0.0034 16.7 0.0 2.5 2 1 0 2 2 2 1 Thi4 family DAO PF01266.24 ORX61974.1 - 0.00018 21.2 0.7 0.94 9.0 0.0 3.2 3 1 0 3 3 3 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ORX61974.1 - 0.0016 17.8 0.6 0.092 12.0 0.0 2.8 2 1 1 3 3 3 1 FAD binding domain FAD_binding_2 PF00890.24 ORX61974.1 - 0.0041 16.3 4.6 0.11 11.6 0.3 3.4 2 1 0 3 3 3 1 FAD binding domain Shikimate_DH PF01488.20 ORX61974.1 - 0.023 14.8 0.1 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 ORX61974.1 - 0.026 13.3 1.3 0.24 10.0 0.1 2.8 4 0 0 4 4 4 0 HI0933-like protein ApbA PF02558.16 ORX61974.1 - 0.061 13.0 0.4 12 5.5 0.1 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA Trp_halogenase PF04820.14 ORX61974.1 - 0.063 12.1 0.3 0.56 9.0 0.1 2.0 2 0 0 2 2 2 0 Tryptophan halogenase IlvN PF07991.12 ORX61974.1 - 0.094 12.3 0.0 6.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_10 PF13460.6 ORX61975.1 - 1.3e-18 67.6 0.0 1.5e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 NAD(P)H-binding Sel1 PF08238.12 ORX61976.1 - 1.1e-40 137.1 24.3 2e-07 31.5 0.1 8.0 8 0 0 8 8 8 7 Sel1 repeat TPR_1 PF00515.28 ORX61976.1 - 1.3 9.0 8.9 21 5.1 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat START PF01852.19 ORX61980.1 - 4.2e-13 49.2 0.0 9.4e-13 48.0 0.0 1.6 1 1 0 1 1 1 1 START domain Glyco_hydro_5_C PF18564.1 ORX61980.1 - 0.0075 16.8 0.0 0.014 15.9 0.0 1.4 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain RabGAP-TBC PF00566.18 ORX61981.1 - 1.6e-53 181.6 0.0 4.3e-53 180.2 0.0 1.8 1 0 0 1 1 1 1 Rab-GTPase-TBC domain HALZ PF02183.18 ORX61981.1 - 0.43 10.8 0.0 0.43 10.8 0.0 5.4 6 0 0 6 6 6 0 Homeobox associated leucine zipper UPF0242 PF06785.11 ORX61981.1 - 1.1 9.3 0.0 1.1 9.3 0.0 4.9 4 1 0 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 ORX61981.1 - 1.7 9.2 37.5 0.069 13.7 10.1 4.7 5 0 0 5 5 5 0 Apg6 coiled-coil region Mt_ATP-synt_D PF05873.12 ORX61981.1 - 2.4 8.0 7.2 0.45 10.3 0.8 2.8 3 0 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) Atg14 PF10186.9 ORX61981.1 - 5.2 6.1 21.9 0.86 8.6 11.1 2.5 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 ORX61981.1 - 7.8 5.3 28.5 6.3 5.6 16.2 3.2 3 0 0 3 3 3 0 Spc7 kinetochore protein DDE_3 PF13358.6 ORX61983.1 - 0.00034 20.4 0.0 0.00038 20.2 0.0 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease Spt46 PF17734.1 ORX61985.1 - 0.0086 15.9 0.1 0.012 15.5 0.1 1.1 1 0 0 1 1 1 1 Spermatogenesis-associated protein 46 Aconitase PF00330.20 ORX61986.1 - 2.4e-154 514.7 0.0 3.3e-154 514.3 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ORX61986.1 - 1.8e-44 151.2 0.0 4.1e-44 150.1 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain Peptidase_C12 PF01088.21 ORX61987.1 - 6.1e-43 147.0 0.0 2.9e-42 144.8 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 ORX61987.1 - 1.4e-08 34.5 0.2 1.4e-08 34.5 0.2 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolases DOCK_N PF16172.5 ORX61987.1 - 0.28 10.0 3.5 0.47 9.3 3.5 1.3 1 0 0 1 1 1 0 DOCK N-terminus DUF872 PF05915.12 ORX61988.1 - 7.2e-17 61.6 0.4 8.6e-17 61.4 0.4 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF872) YrhK PF14145.6 ORX61988.1 - 0.027 14.3 3.8 0.66 9.9 3.2 2.1 1 1 2 3 3 3 0 YrhK-like protein DUF973 PF06157.11 ORX61988.1 - 0.047 12.7 2.2 0.056 12.5 2.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF973) SelR PF01641.18 ORX61989.1 - 1.9e-48 163.5 0.0 7.4e-48 161.6 0.0 2.1 1 0 0 1 1 1 1 SelR domain Glyco_hydro_16 PF00722.21 ORX61989.1 - 2.6e-09 36.8 0.0 6.5e-09 35.5 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 GFA PF04828.14 ORX61989.1 - 0.008 16.5 0.1 0.28 11.6 0.0 2.7 1 1 1 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme LAMTOR5 PF16672.5 ORX61990.1 - 2.7e-20 72.1 0.1 2.9e-20 72.0 0.1 1.0 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 Robl_LC7 PF03259.17 ORX61990.1 - 2e-06 27.5 0.0 2.3e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Roadblock/LC7 domain SRAP PF02586.14 ORX61991.1 - 3.6e-51 173.8 0.0 9.9e-42 142.9 0.0 2.0 1 1 1 2 2 2 2 SOS response associated peptidase (SRAP) GTP_EFTU PF00009.27 ORX61992.1 - 3.7e-58 196.3 0.1 6.7e-58 195.4 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 ORX61992.1 - 2.1e-15 56.5 0.0 5e-15 55.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ORX61992.1 - 4.6e-09 36.3 0.0 1.5e-08 34.6 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ORX61992.1 - 7.3e-07 29.5 0.0 1.8e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX61992.1 - 0.017 15.2 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Rota_NS53 PF00981.17 ORX61992.1 - 0.18 10.7 0.5 2.9 6.6 0.0 2.1 2 0 0 2 2 2 0 Rotavirus RNA-binding Protein 53 (NS53) Metallophos PF00149.28 ORX61993.1 - 2.2e-34 119.8 0.0 2.9e-34 119.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase HCV_NS5a PF01506.19 ORX61993.1 - 0.77 9.7 3.7 1.9 8.5 3.7 1.7 1 0 0 1 1 1 0 Hepatitis C virus non-structural 5a protein membrane anchor Ras PF00071.22 ORX61994.1 - 3.5e-43 147.0 0.0 3.9e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX61994.1 - 4e-11 43.2 0.0 7.3e-11 42.3 0.0 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PET117 PF15786.5 ORX61994.1 - 0.14 12.4 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial ACP_syn_III PF08545.10 ORX61994.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF202 PF02656.15 ORX61995.1 - 0.00023 21.5 0.4 0.00023 21.5 0.4 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF202) PHO4 PF01384.20 ORX61995.1 - 0.81 8.7 9.2 1.2 8.1 9.2 1.3 1 0 0 1 1 1 0 Phosphate transporter family DUF2070 PF09843.9 ORX61995.1 - 9.4 4.4 10.2 12 4.1 10.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Mito_carr PF00153.27 ORX61996.1 - 5.2e-61 202.6 2.1 3.8e-22 78.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX61996.1 - 0.41 9.8 5.9 1.5 7.9 0.2 3.0 2 2 1 3 3 3 0 Gammaproteobacterial serine protease CHZ PF09649.10 ORX61997.1 - 1e-14 53.7 0.8 1e-14 53.7 0.8 3.7 3 1 0 3 3 3 1 Histone chaperone domain CHZ IFT57 PF10498.9 ORX61997.1 - 4.5 6.1 15.1 5.5 5.9 15.1 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 HLH PF00010.26 ORX61998.1 - 3.6e-16 58.9 0.4 3.6e-16 58.9 0.4 1.9 2 1 1 3 3 3 1 Helix-loop-helix DNA-binding domain GCN5L1 PF06320.13 ORX61998.1 - 0.024 14.8 1.8 0.043 14.0 1.8 1.4 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) Fmp27_WPPW PF10359.9 ORX61998.1 - 0.024 13.5 1.5 0.033 13.0 1.5 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF1978 PF09321.10 ORX61998.1 - 0.034 13.4 4.3 0.05 12.9 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1978) Mis12 PF05859.12 ORX61998.1 - 0.13 12.3 1.4 0.93 9.5 1.4 2.1 1 1 0 1 1 1 0 Mis12 protein MerR-DNA-bind PF09278.11 ORX61998.1 - 1.1 9.8 6.2 3.2 8.3 1.1 2.5 2 0 0 2 2 2 0 MerR, DNA binding Cep57_MT_bd PF06657.13 ORX61998.1 - 1.5 9.3 6.7 2.2 8.8 0.9 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 ORX61998.1 - 1.5 8.1 4.7 2.2 7.5 4.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 ORX61998.1 - 5.8 7.4 9.9 0.98 9.9 3.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Fib_alpha PF08702.10 ORX61998.1 - 7.1 6.8 7.5 21 5.3 7.5 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Spectrin PF00435.21 ORX61998.1 - 8.7 6.9 9.4 4.7 7.8 1.4 2.6 3 0 0 3 3 3 0 Spectrin repeat OrfB_Zn_ribbon PF07282.11 ORX61999.1 - 1.3e-08 34.6 2.6 0.00027 20.8 0.2 2.8 2 1 0 2 2 2 2 Putative transposase DNA-binding domain CENP-B_dimeris PF09026.10 ORX61999.1 - 4.5 7.7 8.4 11 6.5 8.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FbpA PF05833.11 ORX62000.1 - 1.2e-42 146.2 4.1 1.2e-42 146.2 4.1 2.1 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 ORX62000.1 - 9.9e-32 109.8 0.0 2.9e-31 108.4 0.0 1.9 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-C PF11923.8 ORX62000.1 - 3.2e-30 104.2 0.2 3.2e-30 104.2 0.2 3.2 1 1 1 2 2 2 1 NFACT protein C-terminal domain DUF469 PF04320.14 ORX62000.1 - 0.062 14.2 1.0 0.27 12.1 0.2 2.5 3 0 0 3 3 3 0 Protein with unknown function (DUF469) Sec63 PF02889.16 ORX62001.1 - 2.2e-142 472.7 0.4 5.3e-82 274.8 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ORX62001.1 - 5.5e-53 179.3 0.3 1.1e-26 93.7 0.2 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 ORX62001.1 - 2e-25 89.8 0.3 1.1e-12 48.3 0.0 2.8 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ORX62001.1 - 2.6e-16 59.9 0.0 1.9e-06 28.1 0.0 3.9 4 1 0 4 4 4 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 ORX62001.1 - 3.7e-06 27.3 0.6 0.32 11.3 0.0 4.0 2 2 0 2 2 2 2 AAA domain Helicase_PWI PF18149.1 ORX62001.1 - 4.7e-06 26.7 0.2 1.7e-05 24.9 0.2 2.0 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_19 PF13245.6 ORX62001.1 - 1.1e-05 25.8 0.7 0.019 15.3 0.2 2.7 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 ORX62001.1 - 1.3e-05 25.6 3.1 0.044 14.2 0.0 3.5 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ORX62001.1 - 0.081 12.7 0.2 6.8 6.4 0.0 3.1 3 0 0 3 3 3 0 IstB-like ATP binding protein PhoH PF02562.16 ORX62001.1 - 0.1 12.0 0.0 3.6 7.0 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein Arf PF00025.21 ORX62002.1 - 3.8e-48 163.2 0.1 4.7e-48 162.9 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ORX62002.1 - 3.7e-14 52.6 0.0 5.2e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 ORX62002.1 - 6.9e-14 51.8 0.3 5.2e-09 35.7 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ORX62002.1 - 1.9e-12 47.4 0.0 3.1e-12 46.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ORX62002.1 - 2.3e-11 43.5 0.0 3e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ORX62002.1 - 6.6e-09 35.8 0.0 1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX62002.1 - 1.6e-08 34.4 0.2 4.6e-05 23.0 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX62002.1 - 1.9e-08 34.0 0.0 2.3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ORX62002.1 - 0.00043 19.8 0.1 0.0014 18.2 0.1 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B TniB PF05621.11 ORX62002.1 - 0.0021 17.5 0.0 0.0033 16.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA_18 PF13238.6 ORX62002.1 - 0.023 15.2 0.0 0.04 14.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ORX62002.1 - 0.06 13.1 0.1 1 9.1 0.0 2.3 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ORX62002.1 - 0.061 13.6 0.0 0.21 11.9 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX62002.1 - 0.12 12.9 0.0 0.15 12.6 0.0 1.3 1 1 0 1 1 1 0 AAA domain DUF2672 PF10878.8 ORX62002.1 - 0.45 10.5 2.5 19 5.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2672) NAD_binding_2 PF03446.15 ORX62003.1 - 1.4e-33 116.3 1.2 2e-33 115.8 1.2 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ORX62003.1 - 2.4e-28 98.8 0.1 4.8e-27 94.6 0.0 2.3 2 1 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase OrfB_Zn_ribbon PF07282.11 ORX62004.1 - 0.0057 16.5 0.8 0.0081 16.1 0.8 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf-C2H2_2 PF12756.7 ORX62006.1 - 0.029 14.7 4.8 0.045 14.1 4.8 1.3 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 ORX62006.1 - 0.064 13.7 15.0 0.081 13.4 0.7 2.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX62006.1 - 0.068 14.0 15.3 0.31 12.0 2.0 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger Rho_Binding PF08912.11 ORX62007.1 - 0.13 13.1 0.0 0.32 11.9 0.0 1.7 1 0 0 1 1 1 0 Rho Binding DUF4604 PF15377.6 ORX62008.1 - 8.1e-12 45.9 23.3 1.4e-11 45.1 23.3 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4604) IFT57 PF10498.9 ORX62008.1 - 6.7 5.6 10.8 9.5 5.1 10.8 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 CytadhesinP1 PF12378.8 ORX62008.1 - 8 6.7 6.3 0.49 10.6 0.5 2.0 2 0 0 2 2 2 0 Trypsin-sensitive surface-exposed protein Pkinase PF00069.25 ORX62009.1 - 6.6e-66 222.4 0.0 1e-65 221.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62009.1 - 5.5e-26 91.4 0.1 1.2e-18 67.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX62009.1 - 4e-08 32.9 1.3 0.0023 17.3 0.0 3.1 3 0 0 3 3 3 3 Kinase-like APH PF01636.23 ORX62009.1 - 0.00045 20.2 0.2 0.028 14.4 0.1 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX62009.1 - 0.00055 18.8 2.2 0.001 17.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ORX62009.1 - 0.077 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RAP1 PF07218.11 ORX62009.1 - 4.3 5.5 6.3 6 5.0 6.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CDP-OH_P_transf PF01066.21 ORX62010.1 - 6.8e-14 52.4 3.1 7.4e-14 52.3 0.7 2.1 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase PH PF00169.29 ORX62011.1 - 2.7e-07 31.0 0.0 5.9e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 PH domain adh_short_C2 PF13561.6 ORX62012.1 - 3.5e-51 174.0 0.0 4.2e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX62012.1 - 2.6e-43 147.8 0.1 3.2e-43 147.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ORX62012.1 - 2.2e-09 37.5 0.1 2.7e-09 37.2 0.1 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX62012.1 - 0.057 12.6 0.1 0.068 12.3 0.1 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF4508 PF14969.6 ORX62013.1 - 0.0005 20.3 0.1 0.00061 20.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) FlgD PF03963.14 ORX62013.1 - 0.012 15.9 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 Flagellar hook capping protein - N-terminal region DNA_alkylation PF08713.11 ORX62013.1 - 0.088 12.5 0.1 0.088 12.5 0.1 1.0 1 0 0 1 1 1 0 DNA alkylation repair enzyme Mito_carr PF00153.27 ORX62015.1 - 2.7e-53 177.9 7.5 8.9e-21 73.6 0.1 4.0 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 ORX62015.1 - 0.00058 19.1 3.8 0.43 9.7 0.2 3.0 2 1 0 3 3 3 3 Gammaproteobacterial serine protease DUF5518 PF17647.1 ORX62015.1 - 0.85 9.8 8.4 0.16 12.1 2.6 2.4 2 1 1 3 3 3 0 Family of unknown function (DUF5518) Sec3_C PF09763.9 ORX62016.1 - 7.2e-157 523.8 4.2 1.1e-156 523.1 4.2 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 ORX62016.1 - 1.8e-20 72.9 1.4 2e-20 72.7 0.2 1.8 2 0 0 2 2 2 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 ORX62016.1 - 4.6e-08 32.3 2.0 4.6e-08 32.3 2.0 2.9 3 0 0 3 3 3 1 Vps52 / Sac2 family Hemerythrin PF01814.23 ORX62016.1 - 0.0066 17.1 0.1 0.0066 17.1 0.1 3.8 3 0 0 3 3 3 1 Hemerythrin HHE cation binding domain U1snRNP70_N PF12220.8 ORX62016.1 - 0.11 13.2 2.7 0.18 12.4 0.4 2.6 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF3915 PF13054.6 ORX62016.1 - 3.7 7.6 8.7 2.3 8.2 6.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) RRM_1 PF00076.22 ORX62017.1 - 1e-30 105.4 0.0 6.4e-19 67.5 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ORX62017.1 - 2.1e-07 31.0 0.1 8.7e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 ORX62017.1 - 2.1e-05 24.1 0.0 0.25 10.9 0.1 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ORX62017.1 - 0.025 14.6 0.0 8.9 6.5 0.0 3.2 3 0 0 3 3 3 0 Limkain b1 OrfB_Zn_ribbon PF07282.11 ORX62018.1 - 5.3e-11 42.3 1.1 9e-11 41.5 1.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain TusA PF01206.17 ORX62018.1 - 0.1 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Sulfurtransferase TusA DZR PF12773.7 ORX62018.1 - 0.18 11.9 4.4 0.32 11.0 4.4 1.4 1 0 0 1 1 1 0 Double zinc ribbon XRCC4 PF06632.12 ORX62019.1 - 0.34 9.7 8.2 4.4 6.1 0.0 2.2 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 RRM_1 PF00076.22 ORX62021.1 - 2.2e-14 53.0 0.0 3.6e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ORX62021.1 - 7.3e-10 38.5 12.2 1.9e-05 24.5 2.5 2.5 2 0 0 2 2 2 2 Zinc knuckle RRM_occluded PF16842.5 ORX62021.1 - 0.0049 16.7 0.0 0.0074 16.1 0.0 1.2 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ORX62021.1 - 0.029 14.4 0.0 0.049 13.7 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif zf-CCHC_4 PF14392.6 ORX62021.1 - 0.035 13.8 4.7 0.73 9.6 0.4 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_2 PF13696.6 ORX62021.1 - 0.041 13.7 0.6 0.041 13.7 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-ribbon_3 PF13248.6 ORX62021.1 - 2.1 7.9 6.4 7.7 6.1 1.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF4551 PF15087.6 ORX62021.1 - 2.4 6.9 9.3 2.2 7.0 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) HscB_4_cys PF18256.1 ORX62021.1 - 4.3 7.2 6.5 11 5.9 0.4 2.5 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif Glucosamine_iso PF01182.20 ORX62022.1 - 1.8e-77 260.2 0.0 2e-77 260.1 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase zf-Mss51 PF13824.6 ORX62026.1 - 0.027 14.6 0.2 3.9 7.6 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Prok-RING_1 PF14446.6 ORX62026.1 - 0.32 11.0 6.1 0.68 9.9 1.0 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 ADK_lid PF05191.14 ORX62026.1 - 0.75 9.8 3.0 0.75 9.8 0.4 2.2 2 0 0 2 2 2 0 Adenylate kinase, active site lid Zn-ribbon_8 PF09723.10 ORX62026.1 - 1.1 9.5 3.7 11 6.3 0.3 2.6 2 0 0 2 2 2 0 Zinc ribbon domain zf-CCHC_6 PF15288.6 ORX62026.1 - 1.1 9.2 7.5 8.8 6.3 0.4 2.7 2 0 0 2 2 2 0 Zinc knuckle DZR PF12773.7 ORX62026.1 - 3.2 7.9 7.5 33 4.6 7.5 2.2 1 1 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 ORX62027.1 - 1.5e-06 28.0 5.4 7.3e-06 25.8 5.4 2.0 1 1 0 1 1 1 1 Putative transposase DNA-binding domain CPL PF08144.11 ORX62028.1 - 6.3e-42 143.3 8.7 1.1e-39 136.0 1.0 4.6 4 1 0 4 4 4 2 CPL (NUC119) domain PUF PF00806.19 ORX62028.1 - 4.2e-06 26.2 0.2 3.4 7.6 0.0 6.3 6 1 1 7 7 7 2 Pumilio-family RNA binding repeat GGA_N-GAT PF18308.1 ORX62028.1 - 0.054 13.1 0.1 0.2 11.3 0.1 1.9 1 0 0 1 1 1 0 GGA N-GAT domain COX6A PF02046.15 ORX62029.1 - 1.6e-25 89.7 2.3 1.8e-25 89.6 2.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Coprogen_oxidas PF01218.18 ORX62029.1 - 0.048 12.4 0.2 0.054 12.2 0.2 1.0 1 0 0 1 1 1 0 Coproporphyrinogen III oxidase EbsA PF17255.2 ORX62030.1 - 7.1 7.0 7.7 6.9 7.0 0.2 2.7 3 0 0 3 3 3 0 EbsA-like protein FANCF PF11107.8 ORX62031.1 - 0.00021 20.6 0.0 0.00029 20.2 0.0 1.2 1 0 0 1 1 1 1 Fanconi anemia group F protein (FANCF) DUF4373 PF14297.6 ORX62031.1 - 0.1 13.4 0.3 0.27 12.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4373) RNA_helicase PF00910.22 ORX62031.1 - 0.12 12.8 0.4 0.19 12.1 0.4 1.3 1 0 0 1 1 1 0 RNA helicase Glyco_transf_20 PF00982.21 ORX62032.1 - 7.4e-157 522.8 0.2 1.1e-156 522.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX62032.1 - 4e-73 245.4 0.0 4e-72 242.1 0.0 2.1 2 0 0 2 2 2 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ORX62032.1 - 0.0068 16.2 0.0 0.04 13.7 0.0 2.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Glycos_transf_1 PF00534.20 ORX62032.1 - 0.029 13.9 0.3 0.66 9.5 0.7 2.6 2 1 0 2 2 2 0 Glycosyl transferases group 1 WD40 PF00400.32 ORX62033.1 - 2.9e-63 208.3 21.3 1.2e-10 41.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62033.1 - 3.6e-24 84.9 3.6 0.0033 17.7 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ORX62033.1 - 1.5e-13 51.1 0.6 1.8e-08 34.5 0.1 3.9 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ORX62033.1 - 7.9e-11 41.3 7.0 0.0069 15.1 0.0 5.2 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ORX62033.1 - 1.5e-07 30.7 4.5 0.0029 16.6 0.2 4.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ORX62033.1 - 3.7e-06 26.1 3.3 0.085 11.8 0.0 4.1 1 1 4 5 5 5 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ORX62033.1 - 4e-06 26.4 0.1 0.0031 16.9 0.0 3.2 2 1 2 4 4 4 2 WD40-like domain Frtz PF11768.8 ORX62033.1 - 0.00022 19.7 0.1 0.0015 16.9 0.0 2.1 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ORX62033.1 - 0.0097 15.8 1.4 1.1 9.3 0.1 3.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ORX62033.1 - 0.016 14.3 0.0 0.076 12.1 0.0 2.0 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ORX62033.1 - 0.037 12.6 0.0 0.45 9.0 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain Utp8 PF10395.9 ORX62033.1 - 0.069 11.6 0.0 0.16 10.5 0.0 1.5 1 1 0 1 1 1 0 Utp8 family Ricin_B_lectin PF00652.22 ORX62033.1 - 0.19 12.0 1.7 0.38 11.0 0.1 2.3 2 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain Ank_2 PF12796.7 ORX62034.1 - 9.6e-19 67.8 0.2 7.6e-08 32.8 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX62034.1 - 1.1e-17 64.1 0.6 8.6e-07 29.4 0.1 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX62034.1 - 7.6e-16 58.0 1.7 1.2e-06 28.7 0.1 3.9 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX62034.1 - 2.7e-15 54.9 2.6 0.00027 21.1 0.1 4.0 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 ORX62034.1 - 2.3e-14 53.1 2.2 5.1e-05 23.5 0.3 4.2 4 0 0 4 4 4 3 Ankyrin repeat DUF3723 PF12520.8 ORX62034.1 - 0.1 11.3 0.0 0.2 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3723) SMP PF04927.12 ORX62035.1 - 0.33 11.5 0.0 0.33 11.5 0.0 2.0 2 0 0 2 2 2 0 Seed maturation protein RNase_T PF00929.24 ORX62036.1 - 6.9e-09 36.5 0.0 3e-08 34.4 0.0 2.0 1 1 0 1 1 1 1 Exonuclease L31 PF09784.9 ORX62036.1 - 0.37 11.3 2.1 6.1 7.3 0.0 2.9 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L31 CRISPR_Cse1 PF09481.10 ORX62037.1 - 0.0079 15.3 0.9 0.035 13.2 0.9 1.8 1 1 0 1 1 1 1 CRISPR-associated protein Cse1 (CRISPR_cse1) Pkinase PF00069.25 ORX62038.1 - 2.7e-77 259.7 0.0 3.9e-77 259.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62038.1 - 2.9e-42 144.7 0.0 4.2e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62038.1 - 1.3e-06 28.0 0.0 1.9e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX62038.1 - 2.7e-05 23.3 0.1 2.7e-05 23.3 0.1 1.7 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 ORX62038.1 - 0.00033 20.6 0.2 0.00059 19.8 0.2 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX62038.1 - 0.0031 16.9 0.1 0.0031 16.9 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family AAA PF00004.29 ORX62039.1 - 4.9e-42 143.5 0.0 2.9e-41 141.0 0.0 2.3 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX62039.1 - 5.5e-10 38.9 0.0 1.3e-09 37.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 ORX62039.1 - 7.6e-06 25.7 0.0 2.4e-05 24.1 0.0 1.9 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ORX62039.1 - 1.5e-05 24.8 0.1 0.0054 16.5 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.14 ORX62039.1 - 2.4e-05 24.3 0.6 0.00012 22.0 0.2 2.5 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ORX62039.1 - 3.9e-05 23.8 0.0 0.00041 20.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ORX62039.1 - 4.5e-05 23.8 4.8 0.0073 16.6 0.4 4.1 2 1 1 3 3 3 1 AAA domain TIP49 PF06068.13 ORX62039.1 - 8.7e-05 21.9 0.1 0.00021 20.6 0.1 1.5 1 1 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ORX62039.1 - 0.00029 20.3 0.0 0.00064 19.2 0.0 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ORX62039.1 - 0.0004 20.6 0.0 0.0036 17.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX62039.1 - 0.00066 20.2 0.0 0.0015 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 ORX62039.1 - 0.00069 19.1 0.6 0.66 9.4 0.0 3.0 2 1 1 3 3 3 2 Bacterial TniB protein AAA_14 PF13173.6 ORX62039.1 - 0.001 19.1 0.0 0.0026 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX62039.1 - 0.0012 18.4 2.3 0.28 10.8 0.0 3.8 4 0 0 4 4 3 1 AAA domain AAA_16 PF13191.6 ORX62039.1 - 0.0022 18.4 6.4 0.023 15.1 0.0 4.0 3 1 0 4 4 3 1 AAA ATPase domain RNA_helicase PF00910.22 ORX62039.1 - 0.0041 17.5 0.0 0.013 15.9 0.0 2.0 1 0 0 1 1 1 1 RNA helicase DUF815 PF05673.13 ORX62039.1 - 0.0094 15.1 0.0 0.018 14.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 ORX62039.1 - 0.019 14.7 0.0 0.035 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX62039.1 - 0.021 15.1 0.0 0.078 13.2 0.0 2.1 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 ORX62039.1 - 0.032 13.7 0.1 0.11 12.0 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 ORX62039.1 - 0.044 13.7 0.1 0.18 11.7 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Parvo_NS1 PF01057.17 ORX62039.1 - 0.045 12.8 0.0 0.084 11.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 cobW PF02492.19 ORX62039.1 - 0.079 12.5 0.0 0.24 11.0 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_3 PF07726.11 ORX62039.1 - 0.082 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PELOTA_1 PF15608.6 ORX62039.1 - 0.091 12.7 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 PELOTA RNA binding domain TrkA_N PF02254.18 ORX62039.1 - 0.11 12.8 0.1 0.31 11.3 0.1 1.8 1 0 0 1 1 1 0 TrkA-N domain TsaE PF02367.17 ORX62039.1 - 0.11 12.5 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ORX62039.1 - 0.14 12.7 0.1 0.52 10.8 0.1 2.1 1 1 0 1 1 1 0 ABC transporter ATPase PF06745.13 ORX62039.1 - 0.14 11.5 0.2 0.6 9.4 0.1 1.9 1 1 1 2 2 2 0 KaiC PhoH PF02562.16 ORX62039.1 - 0.14 11.6 0.0 0.31 10.5 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activat PF00158.26 ORX62039.1 - 0.17 11.6 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain Guanylate_kin PF00625.21 ORX62039.1 - 0.17 11.6 0.3 24 4.6 0.0 3.5 4 0 0 4 4 4 0 Guanylate kinase SLATT_1 PF18181.1 ORX62041.1 - 0.11 12.4 1.2 18 5.3 0.1 2.6 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 NAD_binding_10 PF13460.6 ORX62042.1 - 7.8e-19 68.3 0.0 9.9e-19 67.9 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ORX62042.1 - 4e-17 62.6 0.0 4.5e-16 59.1 0.0 2.0 1 1 0 1 1 1 1 NmrA-like family Epimerase PF01370.21 ORX62042.1 - 5.2e-05 22.8 0.3 0.00021 20.8 0.3 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 ORX62042.1 - 0.00017 21.8 0.0 0.00051 20.3 0.0 1.7 1 1 1 2 2 2 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 ORX62042.1 - 0.0003 19.9 0.0 0.00098 18.2 0.0 1.7 1 1 1 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 ORX62042.1 - 0.00077 19.0 0.1 0.0014 18.1 0.1 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Shikimate_DH PF01488.20 ORX62042.1 - 0.00085 19.4 0.0 0.0014 18.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.15 ORX62042.1 - 0.011 14.9 0.1 1.6 7.8 0.1 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ORX62042.1 - 0.021 14.3 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ORX62042.1 - 0.022 14.0 0.1 0.037 13.2 0.1 1.4 1 0 0 1 1 1 0 Male sterility protein RmlD_sub_bind PF04321.17 ORX62042.1 - 0.031 13.4 0.0 0.05 12.7 0.0 1.3 1 0 0 1 1 1 0 RmlD substrate binding domain DapB_N PF01113.20 ORX62042.1 - 0.038 14.1 0.0 0.08 13.1 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 ORX62042.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 ORX62042.1 - 0.18 11.9 0.1 1.1 9.4 0.1 2.2 1 1 1 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Gln-synt_C PF00120.24 ORX62043.1 - 6.2e-20 71.5 0.0 1.8e-18 66.7 0.0 2.0 1 1 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ORX62043.1 - 1.9e-13 49.9 0.0 3e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Prok-RING_1 PF14446.6 ORX62047.1 - 0.11 12.4 0.4 0.2 11.6 0.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 SRA1 PF07304.11 ORX62050.1 - 1.5e-12 47.5 0.0 1.5e-12 47.5 0.0 4.8 6 1 0 6 6 6 1 Steroid receptor RNA activator (SRA1) Prp18 PF02840.15 ORX62050.1 - 2.1e-06 27.9 0.1 4e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Prp18 domain WD40 PF00400.32 ORX62050.1 - 0.00025 21.7 14.4 3.8 8.6 0.1 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62050.1 - 0.00029 21.1 0.2 9.1 6.7 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Sec16_C PF12931.7 ORX62050.1 - 0.23 11.1 0.1 1.8 8.2 0.0 2.2 2 0 0 2 2 2 0 Sec23-binding domain of Sec16 bZIP_2 PF07716.15 ORX62052.1 - 2.6e-10 40.2 9.5 2.6e-10 40.2 9.5 1.8 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX62052.1 - 8.1e-08 32.3 7.2 8.1e-08 32.3 7.2 1.7 2 0 0 2 2 2 1 bZIP transcription factor TMPIT PF07851.13 ORX62052.1 - 0.015 14.6 1.0 0.019 14.2 1.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein bZIP_Maf PF03131.17 ORX62052.1 - 0.037 14.6 4.6 0.037 14.6 4.6 1.6 1 1 1 2 2 2 0 bZIP Maf transcription factor ABC_tran_CTD PF16326.5 ORX62052.1 - 0.071 13.4 7.1 0.25 11.6 4.4 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF1765 PF08578.10 ORX62053.1 - 6.3e-22 78.4 1.9 2.3e-21 76.5 1.9 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) RTC4 PF14474.6 ORX62054.1 - 1.2e-19 70.7 0.0 1.9e-19 70.0 0.0 1.3 1 0 0 1 1 1 1 RTC4-like domain F1F0-ATPsyn_F PF10791.9 ORX62055.1 - 4.9e-33 113.5 0.0 5.4e-33 113.3 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi WRW PF10206.9 ORX62055.1 - 2.2e-05 24.7 0.0 2.9e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial F1F0-ATP synthase, subunit f Coq4 PF05019.13 ORX62056.1 - 3.3e-94 314.3 0.0 4.4e-94 313.9 0.0 1.2 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 NmrA PF05368.13 ORX62057.1 - 4.4e-17 62.4 0.1 1.9e-10 40.7 0.1 2.1 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 ORX62057.1 - 8.8e-16 58.3 0.0 1.4e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ORX62057.1 - 1.6e-06 27.8 0.8 0.00011 21.7 0.1 2.7 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ORX62057.1 - 8.2e-05 22.2 0.1 0.00018 21.0 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase 3Beta_HSD PF01073.19 ORX62057.1 - 0.00015 20.9 0.0 0.00026 20.1 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Shikimate_DH PF01488.20 ORX62057.1 - 0.0004 20.5 0.0 0.00067 19.7 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.24 ORX62057.1 - 0.0026 18.2 0.0 0.0057 17.1 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain TrkA_N PF02254.18 ORX62057.1 - 0.0039 17.4 0.0 0.0061 16.8 0.0 1.3 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_2 PF03446.15 ORX62057.1 - 0.006 16.8 0.0 0.01 16.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase GDP_Man_Dehyd PF16363.5 ORX62057.1 - 0.0082 15.6 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ORX62057.1 - 0.018 14.2 0.0 0.065 12.4 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein KR PF08659.10 ORX62057.1 - 0.06 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 ORX62057.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 ORX62057.1 - 0.1 11.8 0.0 0.21 10.7 0.0 1.6 2 0 0 2 2 2 0 Male sterility protein FCH PF00611.23 ORX62058.1 - 1.3e-05 25.4 0.7 1.3e-05 25.4 0.7 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain KxDL PF10241.9 ORX62058.1 - 1.1 9.5 10.1 0.32 11.3 3.9 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein PMEI PF04043.15 ORX62058.1 - 9.4 6.6 10.6 1.8 8.9 4.0 2.7 1 1 1 2 2 2 0 Plant invertase/pectin methylesterase inhibitor Copper-fist PF00649.18 ORX62059.1 - 6.3e-20 70.4 2.8 6.3e-20 70.4 2.8 2.2 2 1 0 2 2 2 1 Copper fist DNA binding domain DUF3716 PF12511.8 ORX62059.1 - 4.8 7.3 13.7 0.62 10.2 1.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3716) ATP-synt_C PF00137.21 ORX62061.1 - 6.5e-35 119.3 32.9 9.1e-24 83.6 14.0 2.2 2 0 0 2 2 2 2 ATP synthase subunit C TCR_zetazeta PF11628.8 ORX62061.1 - 1 9.1 5.5 2.9 7.6 1.2 2.4 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain GerA PF03323.13 ORX62061.1 - 4.7 5.6 5.3 8.5 4.7 0.6 2.1 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein Erf4 PF10256.9 ORX62062.1 - 2.6e-32 111.3 0.1 3.6e-32 110.9 0.1 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family TAN PF11640.8 ORX62062.1 - 0.015 15.4 0.1 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair ubiquitin PF00240.23 ORX62063.1 - 7.4e-34 115.3 0.6 8.2e-34 115.2 0.6 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX62063.1 - 1.7e-14 53.4 0.4 1.9e-14 53.2 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX62063.1 - 1e-05 25.9 0.1 4.6e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ORX62063.1 - 0.0015 18.9 0.1 0.0017 18.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX62063.1 - 0.0032 17.6 0.0 0.0072 16.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ORX62063.1 - 0.0047 16.8 0.0 0.0054 16.6 0.0 1.2 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ORX62063.1 - 0.02 15.5 0.1 0.024 15.2 0.1 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX62063.1 - 0.041 13.9 0.2 2.5 8.2 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin-like domain Ras PF00071.22 ORX62064.1 - 7.8e-49 165.4 0.0 9.6e-49 165.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX62064.1 - 9.3e-30 103.3 0.1 2.4e-29 102.0 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX62064.1 - 1.1e-10 41.3 0.0 1.3e-10 41.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 ORX62064.1 - 0.00018 21.9 0.2 0.0011 19.3 0.2 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 ORX62064.1 - 0.0023 17.4 0.0 0.0029 17.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX62064.1 - 0.0034 17.4 0.0 0.0064 16.6 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ORX62064.1 - 0.007 15.9 0.0 0.011 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region G-alpha PF00503.20 ORX62064.1 - 0.0086 15.3 1.0 0.57 9.3 0.1 2.3 2 1 0 2 2 2 1 G-protein alpha subunit Pox_A32 PF04665.12 ORX62064.1 - 0.015 14.8 0.1 0.027 13.9 0.1 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein ArgoMid PF16487.5 ORX62064.1 - 0.022 15.0 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 Mid domain of argonaute AAA_24 PF13479.6 ORX62064.1 - 0.027 14.2 0.3 0.055 13.2 0.2 1.4 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX62064.1 - 0.042 13.8 0.1 7.8 6.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ORX62064.1 - 0.075 13.4 0.1 0.12 12.8 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain TsaE PF02367.17 ORX62064.1 - 0.089 12.8 0.1 0.2 11.6 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ORX62064.1 - 0.11 12.6 0.2 0.22 11.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain NUC153 PF08159.12 ORX62066.1 - 0.003 17.3 3.6 0.76 9.6 0.1 2.9 2 0 0 2 2 2 2 NUC153 domain ATG13 PF10033.9 ORX62067.1 - 1.1e-60 205.3 0.1 1.7e-60 204.7 0.1 1.3 1 0 0 1 1 1 1 Autophagy-related protein 13 NHR2 PF08788.11 ORX62067.1 - 0.47 10.3 1.9 3.4 7.5 0.0 2.8 2 1 1 3 3 3 0 NHR2 domain like SIS PF01380.22 ORX62069.1 - 6.4e-66 220.1 0.3 2.2e-34 118.1 0.1 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 ORX62069.1 - 5.1e-16 59.1 0.0 1.1e-15 57.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ORX62069.1 - 1.4e-11 44.4 0.0 3.2e-11 43.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ORX62069.1 - 0.00012 21.1 0.0 0.00018 20.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.6 ORX62069.1 - 0.054 13.5 0.0 0.15 12.1 0.0 1.8 2 0 0 2 2 2 0 SIS domain NPR2 PF06218.11 ORX62070.1 - 4.8e-118 394.7 5.4 5.9e-92 308.7 10.4 2.9 1 1 1 2 2 2 2 Nitrogen permease regulator 2 NPR3 PF03666.13 ORX62070.1 - 0.0026 16.6 0.2 3.4 6.4 0.0 2.8 2 1 1 3 3 3 2 Nitrogen Permease regulator of amino acid transport activity 3 HTH_26 PF13443.6 ORX62070.1 - 0.18 12.3 0.0 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain Ank_5 PF13857.6 ORX62071.1 - 5.8e-21 74.3 0.7 1.1e-12 47.9 0.4 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX62071.1 - 1.6e-19 70.0 0.3 3.7e-13 49.7 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX62071.1 - 7e-14 50.6 0.1 1.4e-07 31.3 0.0 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ORX62071.1 - 7.9e-14 51.4 1.0 3.9e-07 30.2 0.3 2.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ORX62071.1 - 6.4e-13 49.1 0.1 2.7e-12 47.1 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX62072.1 - 7.6e-14 51.9 0.0 4.5e-07 30.3 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX62072.1 - 3.5e-10 39.9 0.4 6e-09 36.0 0.4 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ORX62072.1 - 2.1e-09 37.8 0.0 3e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX62072.1 - 1.1e-08 35.1 0.1 0.0001 22.6 0.1 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ORX62072.1 - 3.9e-07 29.8 0.0 8.8e-05 22.6 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Vezatin PF12632.7 ORX62073.1 - 2.1e-48 165.1 7.2 2.1e-48 165.1 7.2 1.7 2 0 0 2 2 2 1 Mysoin-binding motif of peroxisomes OGG_N PF07934.12 ORX62073.1 - 0.028 14.5 0.3 0.082 13.0 0.0 1.9 2 1 0 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain SPA PF08616.10 ORX62074.1 - 5.6e-11 42.4 0.0 1.2e-10 41.3 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis DENN PF02141.21 ORX62074.1 - 0.011 15.7 0.1 0.12 12.3 0.0 2.4 2 1 0 2 2 2 0 DENN (AEX-3) domain YqhG PF11079.8 ORX62075.1 - 0.064 12.2 0.2 0.084 11.8 0.2 1.3 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function PRIMA1 PF16101.5 ORX62075.1 - 0.077 13.0 3.5 0.15 12.1 3.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Dscam_C PF12355.8 ORX62075.1 - 0.11 13.4 2.6 0.2 12.6 2.6 1.3 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal CAP_N PF01213.19 ORX62075.1 - 0.13 11.7 3.9 0.22 11.0 3.9 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 ORX62075.1 - 1 9.4 8.7 0.16 12.0 4.9 1.5 2 0 0 2 2 2 0 Mitochondrial fission regulator Pap_E4 PF02711.14 ORX62075.1 - 1.7 9.7 13.7 0.4 11.7 10.2 1.7 2 0 0 2 2 2 0 E4 protein DLH PF01738.18 ORX62077.1 - 7.1e-07 29.0 0.4 2e-06 27.5 0.0 1.9 2 1 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 ORX62077.1 - 0.001 19.0 0.0 0.003 17.5 0.0 1.9 1 0 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal MAM33 PF02330.16 ORX62078.1 - 1.3e-72 244.2 3.3 1.4e-72 244.0 3.3 1.0 1 0 0 1 1 1 1 Mitochondrial glycoprotein C2 PF00168.30 ORX62079.1 - 1.1e-25 89.9 0.1 1.3e-25 89.7 0.1 1.0 1 0 0 1 1 1 1 C2 domain CEP76-C2 PF15627.6 ORX62079.1 - 0.17 11.5 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 CEP76 C2 domain Got1 PF04178.12 ORX62080.1 - 1.7e-32 112.2 17.2 2.4e-32 111.7 17.2 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family DUF2207 PF09972.9 ORX62080.1 - 0.003 16.4 5.3 0.006 15.4 5.3 1.5 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Cyclin_N PF00134.23 ORX62081.1 - 4.7e-42 142.7 0.2 6e-39 132.7 0.0 2.6 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ORX62081.1 - 6.9e-26 90.7 1.7 3.9e-25 88.2 0.0 2.4 2 0 0 2 2 2 1 Cyclin, C-terminal domain Mucin15 PF15672.5 ORX62081.1 - 3.2 7.2 8.8 3.2 7.2 7.8 1.4 1 1 0 1 1 1 0 Cell-membrane associated Mucin15 SAM_Ste50p PF09235.10 ORX62082.1 - 0.0031 17.7 0.7 1.1 9.5 0.1 3.5 4 0 0 4 4 4 1 Ste50p, sterile alpha motif Zn-ribbon_8 PF09723.10 ORX62082.1 - 0.015 15.4 2.2 0.044 13.9 2.2 1.7 1 0 0 1 1 1 0 Zinc ribbon domain CENP-B_dimeris PF09026.10 ORX62082.1 - 0.026 14.9 3.9 0.048 14.0 1.0 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ORX62082.1 - 0.5 10.1 16.6 0.94 9.2 16.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein LRR_6 PF13516.6 ORX62082.1 - 2.7 8.3 20.5 3.4 8.0 0.4 7.6 9 0 0 9 9 9 0 Leucine Rich repeat Nucleo_P87 PF07267.11 ORX62082.1 - 3.1 6.5 8.1 6 5.6 8.1 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribosomal_60s PF00428.19 ORX62082.1 - 4.7 7.9 7.3 25 5.5 0.2 3.0 3 0 0 3 3 3 0 60s Acidic ribosomal protein DUF1246 PF06849.12 ORX62083.1 - 0.086 12.8 0.1 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1246) FMO-like PF00743.19 ORX62084.1 - 3.1e-26 91.9 2.2 2.3e-16 59.3 0.2 3.3 3 2 0 3 3 3 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 ORX62084.1 - 9.3e-24 84.2 0.6 8.6e-12 44.9 0.0 3.7 4 1 0 4 4 4 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ORX62084.1 - 3e-17 62.6 0.2 3.2e-09 36.9 0.0 3.4 3 0 0 3 3 3 2 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX62084.1 - 6.5e-14 51.9 0.0 4.6e-08 32.7 0.0 4.1 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX62084.1 - 1.9e-12 47.0 0.0 0.0011 18.2 0.0 4.3 4 0 0 4 4 4 3 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ORX62084.1 - 9.1e-06 25.7 1.2 0.19 11.7 0.0 4.9 6 0 0 6 6 6 1 FAD-NAD(P)-binding DAO PF01266.24 ORX62084.1 - 3.9e-05 23.4 0.2 0.0036 16.9 0.0 3.6 4 0 0 4 4 4 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ORX62084.1 - 0.00023 20.6 0.0 0.61 9.3 0.0 3.0 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Thi4 PF01946.17 ORX62084.1 - 0.0032 16.7 1.5 0.25 10.5 0.1 3.1 4 0 0 4 4 4 1 Thi4 family Pyr_redox PF00070.27 ORX62084.1 - 0.0034 17.9 0.0 8.3 7.0 0.1 3.7 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ORX62084.1 - 0.035 13.5 0.1 0.23 10.8 0.0 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_7 PF13241.6 ORX62084.1 - 0.051 14.0 0.0 26 5.3 0.0 3.1 3 0 0 3 3 2 0 Putative NAD(P)-binding FAD_binding_2 PF00890.24 ORX62084.1 - 0.083 11.9 0.3 0.26 10.3 0.2 1.8 2 0 0 2 2 2 0 FAD binding domain GIDA PF01134.22 ORX62084.1 - 0.22 10.6 0.5 8.6 5.3 0.1 2.5 3 0 0 3 3 3 0 Glucose inhibited division protein A CUE PF02845.16 ORX62085.1 - 2.2e-06 27.2 0.1 4.8e-06 26.1 0.1 1.6 1 0 0 1 1 1 1 CUE domain Rhomboid PF01694.22 ORX62085.1 - 0.00016 21.7 4.8 0.00031 20.8 4.8 1.6 1 1 0 1 1 1 1 Rhomboid family DER1 PF04511.15 ORX62085.1 - 0.0027 17.7 6.0 0.0042 17.1 6.0 1.3 1 0 0 1 1 1 1 Der1-like family UBA PF00627.31 ORX62085.1 - 0.0034 17.3 0.0 0.01 15.7 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain STT3 PF02516.14 ORX62087.1 - 2.1e-148 495.3 37.3 1.2e-142 476.3 34.9 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit WD40 PF00400.32 ORX62088.1 - 9.4e-13 48.4 4.6 1.1 10.2 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat BBS2_N PF14781.6 ORX62088.1 - 0.098 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal Methyltransf_11 PF08241.12 ORX62089.1 - 8.2e-06 26.4 0.0 2.7e-05 24.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX62089.1 - 1.9e-05 25.3 0.0 0.00022 21.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX62089.1 - 4.2e-05 24.2 0.0 7.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX62089.1 - 0.00021 21.1 0.0 0.00027 20.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX62089.1 - 0.0003 20.7 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ORX62089.1 - 0.00038 19.5 0.0 0.00048 19.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ribosomal_L38e PF01781.18 ORX62090.1 - 3.9e-33 113.4 3.0 4.6e-33 113.1 3.0 1.1 1 0 0 1 1 1 1 Ribosomal L38e protein family UPF0086 PF01868.16 ORX62090.1 - 0.046 13.7 0.1 0.06 13.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function UPF0086 Lyase_8 PF02278.18 ORX62091.1 - 2e-48 165.1 0.0 2e-47 161.8 0.0 2.1 2 0 0 2 2 2 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 ORX62091.1 - 2.6e-15 56.1 2.0 6.8e-15 54.8 1.3 1.9 2 0 0 2 2 2 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 ORX62091.1 - 0.00088 19.7 0.0 0.0021 18.5 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain LRR_8 PF13855.6 ORX62092.1 - 3.9e-15 55.3 16.4 6.2e-10 38.7 5.9 2.8 2 1 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ORX62092.1 - 5.7e-07 29.8 23.0 0.00041 20.7 1.9 4.7 2 1 5 7 7 7 6 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ORX62092.1 - 0.046 14.3 20.7 16 6.5 0.2 7.6 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_9 PF14580.6 ORX62092.1 - 0.16 11.5 8.0 0.096 12.2 3.5 2.2 1 1 1 2 2 2 0 Leucine-rich repeat LRR_6 PF13516.6 ORX62092.1 - 1.3 9.2 15.2 1.1 9.5 0.5 4.9 5 0 0 5 5 5 0 Leucine Rich repeat Ribosomal_L9_C PF03948.14 ORX62093.1 - 5.2e-13 49.3 3.0 8.8e-13 48.5 0.2 2.2 1 1 1 2 2 2 1 Ribosomal protein L9, C-terminal domain Ribosomal_L9_N PF01281.19 ORX62093.1 - 1.6e-11 43.6 0.1 2.8e-11 42.8 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain FAM35_C PF15793.5 ORX62093.1 - 0.022 14.2 0.1 0.04 13.3 0.1 1.5 1 1 0 1 1 1 0 Protein family FAM35, C-terminal Peptidase_C58 PF03543.14 ORX62093.1 - 0.037 13.7 0.7 0.047 13.4 0.7 1.1 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen Alba PF01918.21 ORX62094.1 - 1.6e-14 53.5 2.5 1.9e-14 53.2 2.5 1.1 1 0 0 1 1 1 1 Alba Rhomboid PF01694.22 ORX62095.1 - 7.9e-22 77.9 13.7 7.9e-22 77.9 13.7 2.2 2 1 1 3 3 3 1 Rhomboid family DUF3099 PF11298.8 ORX62095.1 - 0.38 10.9 2.9 0.51 10.5 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3099) Exo_endo_phos PF03372.23 ORX62096.1 - 3e-17 62.9 0.0 5.3e-17 62.1 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ORX62096.1 - 0.046 13.6 0.5 0.22 11.4 0.5 2.1 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase TylF PF05711.11 ORX62096.1 - 0.16 11.2 0.0 0.51 9.6 0.0 1.7 2 0 0 2 2 2 0 Macrocin-O-methyltransferase (TylF) SWI-SNF_Ssr4 PF08549.10 ORX62097.1 - 8.1e-13 47.9 8.6 8.1e-13 47.9 8.6 2.3 1 1 0 2 2 2 1 Fungal domain of unknown function (DUF1750) MIEAP PF16026.5 ORX62097.1 - 0.19 11.9 5.1 1.3 9.1 0.4 2.2 2 0 0 2 2 2 0 Mitochondria-eating protein COQ7 PF03232.13 ORX62097.1 - 0.58 9.9 4.0 2.1 8.1 4.0 1.9 1 1 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Proteasome PF00227.26 ORX62098.1 - 3e-43 147.5 0.0 4.6e-43 146.9 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ORX62098.1 - 1.3e-11 44.0 0.2 2.1e-11 43.3 0.2 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Nramp PF01566.18 ORX62099.1 - 6.6e-104 347.7 13.3 9.2e-104 347.2 13.3 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein Usp PF00582.26 ORX62100.1 - 1.8e-22 80.4 0.5 2.4e-22 80.0 0.5 1.1 1 0 0 1 1 1 1 Universal stress protein family CHCH PF06747.13 ORX62101.1 - 0.00011 22.2 5.1 0.00011 22.2 5.1 2.0 1 1 1 2 2 2 1 CHCH domain rpo132 PF12415.8 ORX62102.1 - 5.7 6.3 17.6 2.7e+02 1.0 0.0 8.2 9 1 1 10 10 10 0 Poxvirus DNA dependent RNA polymerase Mrx7 PF10906.8 ORX62104.1 - 1e-05 25.7 0.4 1.5e-05 25.2 0.4 1.3 1 0 0 1 1 1 1 MIOREX complex component 7 DUF2370 PF10176.9 ORX62105.1 - 2.2e-66 223.7 2.8 5.2e-56 189.8 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2370) Tetraspanin PF00335.20 ORX62105.1 - 0.19 11.4 0.5 1 9.0 0.0 2.0 2 0 0 2 2 2 0 Tetraspanin family TMEM252 PF15664.5 ORX62105.1 - 0.47 10.2 5.3 0.7 9.6 0.3 2.9 3 0 0 3 3 3 0 Transmembrane protein 252 family Pkinase PF00069.25 ORX62107.1 - 6.7e-65 219.1 0.0 7.9e-65 218.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62107.1 - 8.1e-23 81.0 0.0 1.2e-22 80.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62107.1 - 2e-06 27.4 0.0 4.3e-05 23.0 0.0 2.5 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX62107.1 - 0.014 15.3 0.0 0.07 13.0 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family DUF1679 PF07914.11 ORX62107.1 - 0.018 14.0 0.1 0.093 11.6 0.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1679) Kdo PF06293.14 ORX62107.1 - 0.019 14.3 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX62107.1 - 0.12 11.1 0.2 8.9 5.0 0.0 2.1 1 1 0 2 2 2 0 Fungal protein kinase FTA2 PF13095.6 ORX62107.1 - 0.14 11.8 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 AA_kinase PF00696.28 ORX62109.1 - 1.2e-37 129.8 0.8 1.9e-37 129.2 0.1 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 ORX62109.1 - 7.1e-13 48.2 5.8 4e-08 32.9 2.1 2.6 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 ORX62109.1 - 1.2e-12 47.3 1.2 3.8e-05 23.4 0.1 2.6 2 0 0 2 2 2 2 ACT domain FMN_red PF03358.15 ORX62109.1 - 0.078 12.7 0.8 0.82 9.4 0.1 2.6 3 0 0 3 3 3 0 NADPH-dependent FMN reductase PseudoU_synth_1 PF01416.20 ORX62110.1 - 7.1e-09 36.1 0.0 3.1e-08 34.0 0.0 2.1 2 0 0 2 2 2 1 tRNA pseudouridine synthase Asp PF00026.23 ORX62111.1 - 1e-77 261.7 0.0 1.2e-77 261.4 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX62111.1 - 2.2e-15 57.3 0.3 7.5e-08 32.8 0.0 3.2 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX62111.1 - 3e-05 24.6 0.1 0.43 11.3 0.0 2.9 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ORX62111.1 - 0.019 15.5 0.0 5.9 7.5 0.0 3.3 2 2 0 2 2 2 0 gag-polyprotein putative aspartyl protease zf-RNPHF PF08080.12 ORX62111.1 - 0.033 14.2 0.3 0.074 13.0 0.3 1.6 1 0 0 1 1 1 0 RNPHF zinc finger zf-C2H2_2 PF12756.7 ORX62112.1 - 1.9e-34 118.0 15.4 1.8e-30 105.2 1.1 3.9 3 1 1 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 ORX62112.1 - 4.3e-14 52.4 20.3 3.1e-10 40.0 5.8 4.2 3 1 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX62112.1 - 2.2e-08 34.2 2.4 2.2e-08 34.2 2.4 3.0 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ORX62112.1 - 0.0064 17.2 15.9 0.4 11.6 0.3 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-DBF PF07535.12 ORX62112.1 - 0.022 14.8 1.2 0.022 14.8 1.2 3.7 4 0 0 4 4 4 0 DBF zinc finger zf_C2H2_ZHX PF18387.1 ORX62112.1 - 0.067 12.8 3.8 14 5.4 0.1 3.3 3 0 0 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-LYAR PF08790.11 ORX62112.1 - 0.21 11.6 9.0 2.3 8.2 0.2 3.9 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger ProRS-C_1 PF09180.11 ORX62112.1 - 0.25 11.6 5.1 2.4 8.4 0.2 3.3 2 1 1 3 3 3 0 Prolyl-tRNA synthetase, C-terminal AKAP95 PF04988.12 ORX62112.1 - 6.5 7.0 10.6 6.6 6.9 0.4 3.2 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) zf-H2C2_2 PF13465.6 ORX62112.1 - 9.1 6.9 10.0 74 4.0 0.1 4.5 4 0 0 4 4 4 0 Zinc-finger double domain NCE101 PF11654.8 ORX62113.1 - 4e-11 42.4 0.0 6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Non-classical export protein 1 UDPGT PF00201.18 ORX62114.1 - 2.7e-17 62.7 0.5 2.3e-16 59.7 0.5 2.1 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 ORX62114.1 - 1.5e-07 31.6 0.0 5.1e-06 26.6 0.0 3.0 4 0 0 4 4 4 1 Glycosyltransferase family 28 C-terminal domain Glyco_transf_4 PF13439.6 ORX62114.1 - 0.00013 22.0 0.5 0.0019 18.2 0.1 2.7 2 1 0 2 2 2 1 Glycosyltransferase Family 4 LpxK PF02606.14 ORX62114.1 - 0.0032 16.6 0.0 0.005 16.0 0.0 1.3 1 0 0 1 1 1 1 Tetraacyldisaccharide-1-P 4'-kinase AAA_31 PF13614.6 ORX62114.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ACT_7 PF13840.6 ORX62114.1 - 0.15 11.9 0.0 0.28 11.0 0.0 1.4 1 0 0 1 1 1 0 ACT domain RICTOR_N PF14664.6 ORX62115.1 - 3.5e-100 335.6 5.5 5.4e-86 288.9 0.4 2.4 2 0 0 2 2 2 2 Rapamycin-insensitive companion of mTOR, N-term RasGEF_N_2 PF14663.6 ORX62115.1 - 7.3e-38 129.3 2.1 2e-35 121.4 0.2 3.6 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 ORX62115.1 - 9.9e-32 108.8 3.1 5.6e-29 100.0 0.1 5.5 5 1 2 7 7 7 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 ORX62115.1 - 4.4e-30 103.7 5.8 3.8e-29 100.7 0.1 4.7 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 ORX62115.1 - 1.4e-06 28.3 3.1 4.2e-06 26.8 3.1 1.8 1 0 0 1 1 1 1 Hr1 repeat Adaptin_N PF01602.20 ORX62115.1 - 0.0005 18.8 5.7 0.85 8.1 0.1 3.4 3 0 0 3 3 3 3 Adaptin N terminal region Arm PF00514.23 ORX62115.1 - 0.0047 16.9 13.9 3.2 7.9 0.1 6.8 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX62115.1 - 0.025 14.9 8.1 0.061 13.7 0.2 4.8 6 1 0 6 6 5 0 HEAT repeats UME PF08064.13 ORX62115.1 - 0.051 13.5 0.1 1.1 9.2 0.1 2.9 3 0 0 3 3 3 0 UME (NUC010) domain bcl-2I13 PF12201.8 ORX62115.1 - 0.068 13.1 0.2 0.15 11.9 0.2 1.5 1 0 0 1 1 1 0 Bcl2-interacting killer, BH3-domain containing DUF4300 PF14133.6 ORX62115.1 - 0.11 12.2 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4300) Corona_S2 PF01601.16 ORX62115.1 - 0.23 9.9 0.3 0.48 8.9 0.3 1.4 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein Cys_Met_Meta_PP PF01053.20 ORX62116.1 - 1.3e-127 425.6 0.0 1.4e-127 425.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX62116.1 - 0.0012 18.1 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II ThiF PF00899.21 ORX62117.1 - 1e-36 126.6 0.0 1.3e-36 126.2 0.0 1.0 1 0 0 1 1 1 1 ThiF family MFS_1 PF07690.16 ORX62118.1 - 9.6e-08 31.3 21.0 4.7e-07 29.1 10.1 2.9 1 1 1 2 2 2 2 Major Facilitator Superfamily RabGAP-TBC PF00566.18 ORX62120.1 - 1e-40 139.7 0.0 1.6e-40 139.0 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase PF00069.25 ORX62120.1 - 1.5e-29 103.2 0.0 2.3e-29 102.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62120.1 - 2.5e-16 59.8 0.0 1.7e-15 57.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Rhodanese PF00581.20 ORX62120.1 - 2.7e-07 31.1 0.0 5.9e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kinase-like PF14531.6 ORX62120.1 - 0.025 13.9 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ORX62120.1 - 0.094 12.1 0.1 0.24 10.7 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SYF2 PF08231.12 ORX62121.1 - 2.5e-46 158.0 19.2 2.5e-46 158.0 19.2 2.2 1 1 1 2 2 2 1 SYF2 splicing factor TRAP-delta PF05404.12 ORX62121.1 - 0.11 12.0 1.0 0.4 10.2 0.1 2.0 2 0 0 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) F-box-like PF12937.7 ORX62122.1 - 8.1e-05 22.4 0.9 8.1e-05 22.4 0.9 2.5 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 ORX62122.1 - 0.056 13.3 3.6 0.088 12.7 0.7 2.4 2 0 0 2 2 2 0 F-box domain UNC45-central PF11701.8 ORX62122.1 - 0.096 12.6 0.3 0.28 11.1 0.1 1.8 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central VPR PF00522.18 ORX62122.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 VPR/VPX protein DUF3425 PF11905.8 ORX62123.1 - 2.6e-10 40.3 0.1 6.5e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_2 PF07716.15 ORX62123.1 - 0.0017 18.4 10.9 0.0037 17.3 10.9 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX62123.1 - 0.0069 16.5 6.3 0.0069 16.5 6.3 1.6 2 0 0 2 2 2 1 bZIP transcription factor Radial_spoke_3 PF06098.11 ORX62123.1 - 0.0081 15.5 1.1 0.014 14.7 1.1 1.2 1 0 0 1 1 1 1 Radial spoke protein 3 VKG_Carbox PF05090.14 ORX62124.1 - 0.033 13.0 0.0 0.035 13.0 0.0 1.1 1 0 0 1 1 1 0 Vitamin K-dependent gamma-carboxylase ANAPC4_WD40 PF12894.7 ORX62125.1 - 2e-14 53.6 0.1 6.1e-05 23.2 0.0 4.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX62125.1 - 2.7e-11 43.8 2.6 4.6e-05 24.1 0.0 5.4 6 0 0 6 6 4 2 WD domain, G-beta repeat eIF2A PF08662.11 ORX62125.1 - 0.00018 21.4 1.0 0.45 10.4 0.1 3.5 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A ADIP PF11559.8 ORX62125.1 - 0.007 16.5 4.2 0.013 15.6 4.2 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding HAUS5 PF14817.6 ORX62125.1 - 0.0078 15.0 2.7 0.012 14.4 2.7 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 Spc7 PF08317.11 ORX62125.1 - 0.012 14.6 0.8 0.019 13.9 0.8 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein IFT57 PF10498.9 ORX62125.1 - 0.013 14.5 0.8 0.021 13.8 0.8 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF641 PF04859.12 ORX62125.1 - 0.016 15.6 0.6 0.041 14.2 0.3 1.9 2 0 0 2 2 1 0 Plant protein of unknown function (DUF641) RasGAP_C PF03836.15 ORX62125.1 - 0.017 15.3 0.6 0.043 14.0 0.6 1.7 1 0 0 1 1 1 0 RasGAP C-terminus DUF812 PF05667.11 ORX62125.1 - 0.018 13.9 0.5 0.032 13.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Ge1_WD40 PF16529.5 ORX62125.1 - 0.02 13.8 0.1 0.51 9.2 0.0 2.5 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TPR_MLP1_2 PF07926.12 ORX62125.1 - 0.037 14.1 3.7 0.066 13.3 3.7 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 ORX62125.1 - 0.041 14.4 0.1 0.079 13.5 0.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region PQQ_3 PF13570.6 ORX62125.1 - 0.048 14.2 0.0 19 5.9 0.0 3.1 2 0 0 2 2 2 0 PQQ-like domain CC2-LZ PF16516.5 ORX62125.1 - 0.079 13.3 2.1 0.16 12.4 2.1 1.4 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HIP1_clath_bdg PF16515.5 ORX62125.1 - 0.091 13.4 3.3 0.22 12.2 3.3 1.6 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Bacillus_HBL PF05791.11 ORX62125.1 - 0.091 12.6 0.2 0.2 11.5 0.2 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF1664 PF07889.12 ORX62125.1 - 0.17 11.9 0.3 0.31 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PI3K_P85_iSH2 PF16454.5 ORX62125.1 - 0.19 11.3 1.8 0.35 10.5 1.8 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CLZ PF16526.5 ORX62125.1 - 0.2 12.0 3.2 0.39 11.1 3.2 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4078 PF13300.6 ORX62125.1 - 0.21 11.9 1.5 0.44 10.9 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4078) Golgin_A5 PF09787.9 ORX62125.1 - 0.37 10.2 4.5 0.59 9.6 4.5 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 GrpE PF01025.19 ORX62125.1 - 0.46 10.1 4.2 0.22 11.2 1.8 1.7 2 0 0 2 2 1 0 GrpE IKI3 PF04762.12 ORX62126.1 - 7.6e-285 947.6 0.6 1e-284 947.1 0.6 1.2 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 ORX62126.1 - 4.6e-09 36.5 0.3 0.78 10.1 0.0 5.4 3 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain VPS9 PF02204.18 ORX62126.1 - 0.012 15.8 0.2 0.035 14.3 0.2 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 9 (VPS9) domain TFIIIC_delta PF12657.7 ORX62126.1 - 0.018 15.0 0.0 0.043 13.8 0.0 1.7 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term V_ATPase_I PF01496.19 ORX62126.1 - 0.055 11.4 5.1 0.33 8.8 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family NPV_P10 PF05531.12 ORX62126.1 - 0.075 13.5 1.2 3.1 8.3 0.1 3.6 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Clathrin PF00637.20 ORX62126.1 - 0.38 10.6 7.2 0.34 10.8 0.6 3.4 2 1 2 4 4 4 0 Region in Clathrin and VPS Xpo1 PF08389.12 ORX62126.1 - 0.8 9.8 3.2 3.8 7.5 1.6 2.7 2 1 1 3 3 3 0 Exportin 1-like protein RNA_pol_Rpb1_5 PF04998.17 ORX62127.1 - 4e-107 357.6 0.2 7.4e-107 356.7 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 ORX62127.1 - 2.9e-101 338.9 0.0 4.9e-101 338.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 ORX62127.1 - 6.7e-77 257.4 0.4 1.7e-76 256.1 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 ORX62127.1 - 2.5e-67 226.4 0.5 5.6e-67 225.3 0.0 1.9 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 ORX62127.1 - 4.5e-52 176.1 0.0 1e-51 175.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 ORX62127.1 - 6.7e-50 168.6 5.1 1.2e-49 167.7 5.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 ORX62127.1 - 2.4e-38 130.4 0.2 5.4e-38 129.2 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 ORX62127.1 - 0.56 10.7 304.6 0.32 11.5 8.8 14.3 3 1 15 21 21 21 0 RNA polymerase Rpb1 C-terminal repeat DUF3783 PF12646.7 ORX62128.1 - 0.02 14.8 0.1 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) Rad60-SLD PF11976.8 ORX62130.1 - 2.1e-20 72.3 2.2 7.7e-19 67.3 0.7 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ORX62130.1 - 0.00066 19.4 1.4 0.0013 18.4 0.4 2.0 2 0 0 2 2 2 1 Ubiquitin family bZIP_2 PF07716.15 ORX62131.1 - 4e-07 30.0 10.0 5.5e-07 29.6 6.9 2.2 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 ORX62131.1 - 3.1e-06 27.2 9.4 5.7e-06 26.3 9.4 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 ORX62131.1 - 0.0036 17.8 6.0 0.0067 16.9 6.0 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor Fer4_24 PF18109.1 ORX62131.1 - 1.8 8.9 5.3 5 7.5 0.9 2.5 2 0 0 2 2 2 0 Ferredoxin I 4Fe-4S cluster domain Nup54 PF13874.6 ORX62131.1 - 3 8.0 8.8 4.3 7.4 8.8 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 HSF_DNA-bind PF00447.17 ORX62133.1 - 2.3e-29 101.8 0.7 2.3e-29 101.8 0.7 1.9 2 0 0 2 2 2 1 HSF-type DNA-binding CENP-K PF11802.8 ORX62133.1 - 0.0037 16.9 1.6 0.0055 16.3 1.6 1.2 1 0 0 1 1 1 1 Centromere-associated protein K HIP1_clath_bdg PF16515.5 ORX62133.1 - 0.025 15.2 5.9 0.044 14.4 5.9 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nup54_C PF18437.1 ORX62133.1 - 0.15 12.0 2.7 0.51 10.3 2.7 1.9 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain EMC3_TMCO1 PF01956.16 ORX62133.1 - 2.4 7.8 5.5 4.1 7.1 5.5 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DMT_YdcZ PF04657.13 ORX62135.1 - 4e-31 108.1 10.3 4.8e-31 107.9 10.3 1.1 1 0 0 1 1 1 1 Putative inner membrane exporter, YdcZ TctB PF07331.11 ORX62135.1 - 0.077 13.3 12.1 0.11 12.8 12.1 1.2 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family Peptidase_M41 PF01434.18 ORX62136.1 - 3.2e-63 213.0 1.4 5.8e-63 212.2 1.4 1.4 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 ORX62136.1 - 2.9e-43 147.5 0.0 1.6e-42 145.1 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX62136.1 - 7.4e-13 48.1 0.0 1.7e-12 47.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ORX62136.1 - 1.4e-06 28.4 0.0 4.8e-06 26.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX62136.1 - 1.3e-05 25.5 0.6 0.012 15.8 0.0 3.8 4 0 0 4 4 4 1 AAA domain RuvB_N PF05496.12 ORX62136.1 - 1.7e-05 24.7 0.0 0.00028 20.7 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ORX62136.1 - 2e-05 24.0 0.0 5e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 ORX62136.1 - 7.1e-05 23.3 2.2 0.00033 21.1 0.1 3.0 2 2 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ORX62136.1 - 0.00025 21.2 0.0 0.0012 18.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ORX62136.1 - 0.0012 18.1 0.0 0.0031 16.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ORX62136.1 - 0.0049 16.6 0.0 0.016 14.9 0.0 1.9 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 ORX62136.1 - 0.0052 17.3 0.0 0.018 15.6 0.0 2.0 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ORX62136.1 - 0.0056 16.1 0.5 0.013 14.9 0.5 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ORX62136.1 - 0.015 14.8 1.8 0.37 10.3 0.3 3.0 1 1 1 3 3 3 0 AAA domain AAA_14 PF13173.6 ORX62136.1 - 0.02 15.0 0.0 0.094 12.7 0.0 2.2 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 ORX62136.1 - 0.023 14.9 0.0 0.065 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ORX62136.1 - 0.034 14.1 0.1 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain TsaE PF02367.17 ORX62136.1 - 0.037 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ORX62136.1 - 0.046 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ORX62136.1 - 0.063 13.0 0.0 0.29 10.8 0.0 2.1 3 0 0 3 3 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 ORX62136.1 - 0.065 12.7 0.1 0.29 10.6 0.1 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ORX62136.1 - 0.067 12.9 0.0 0.2 11.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ORX62136.1 - 0.085 12.2 2.4 0.82 9.0 0.3 3.1 3 1 0 3 3 3 0 KaiC AAA_30 PF13604.6 ORX62136.1 - 0.23 11.2 4.5 0.5 10.1 0.4 2.6 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ORX62136.1 - 0.34 11.2 3.5 1.7 9.0 0.3 2.8 2 1 0 2 2 2 0 AAA domain F-box-like PF12937.7 ORX62137.1 - 4.2e-08 32.9 2.2 5e-08 32.7 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ORX62137.1 - 0.022 14.6 0.1 0.12 12.3 0.1 2.3 1 0 0 1 1 1 0 F-box domain LRR_9 PF14580.6 ORX62137.1 - 0.045 13.3 0.0 1 8.8 0.0 2.9 3 0 0 3 3 3 0 Leucine-rich repeat FBA_2 PF07735.17 ORX62137.1 - 3.4 7.9 6.8 1.1 9.4 0.2 3.8 5 1 1 6 6 6 0 F-box associated RRM_1 PF00076.22 ORX62138.1 - 5.8e-56 186.2 0.1 5e-20 71.1 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ORX62138.1 - 5.9e-09 35.6 0.1 0.00017 21.2 0.0 2.8 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX62138.1 - 7.2e-07 29.2 0.5 0.12 12.5 0.0 3.8 3 2 1 4 4 4 3 RNA recognition motif RRM_occluded PF16842.5 ORX62138.1 - 1.4e-05 24.8 0.0 0.0065 16.3 0.0 3.3 3 1 0 3 3 3 1 Occluded RNA-recognition motif PHM7_cyt PF14703.6 ORX62138.1 - 0.00074 19.8 0.1 3.2 7.9 0.0 3.3 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter SET_assoc PF11767.8 ORX62138.1 - 0.0026 17.3 0.2 0.75 9.5 0.0 2.6 2 0 0 2 2 2 2 Histone lysine methyltransferase SET associated Cas_Cas2CT1978 PF09707.10 ORX62138.1 - 0.0041 17.1 0.7 0.58 10.3 0.1 2.9 3 0 0 3 3 3 1 CRISPR-associated protein (Cas_Cas2CT1978) Nup35_RRM_2 PF14605.6 ORX62138.1 - 0.0042 17.0 0.1 0.42 10.7 0.0 2.8 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RSD-2 PF07547.13 ORX62138.1 - 0.037 14.5 0.2 3.9 8.0 0.0 2.6 2 0 0 2 2 2 0 RSD-2 N-terminal domain Limkain-b1 PF11608.8 ORX62138.1 - 0.038 14.1 0.2 1.3 9.1 0.0 2.6 3 0 0 3 3 3 0 Limkain b1 DUF5130 PF17174.4 ORX62138.1 - 0.16 12.2 0.0 18 5.5 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5130) Ras PF00071.22 ORX62140.1 - 8.2e-53 178.3 0.0 9.6e-53 178.1 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX62140.1 - 9.5e-23 80.7 0.0 1.5e-22 80.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX62140.1 - 1.1e-08 34.7 0.0 1.5e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX62140.1 - 0.00019 21.5 0.0 0.00034 20.7 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX62140.1 - 0.00045 19.8 0.3 0.00081 19.0 0.0 1.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ORX62140.1 - 0.0008 18.8 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX62140.1 - 0.0016 18.4 0.1 0.82 9.5 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ORX62140.1 - 0.081 13.0 0.3 0.19 11.8 0.1 1.7 2 0 0 2 2 2 0 Dynamin family Homoserine_dh PF00742.19 ORX62141.1 - 3.1e-49 167.2 0.0 5.4e-49 166.4 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase BolA PF01722.18 ORX62141.1 - 4.2e-22 78.2 0.8 7.2e-22 77.4 0.8 1.3 1 0 0 1 1 1 1 BolA-like protein NAD_binding_3 PF03447.16 ORX62141.1 - 6.5e-15 55.8 0.0 1.3e-14 54.8 0.0 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 ORX62141.1 - 0.00067 20.1 0.0 0.002 18.6 0.0 1.8 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 ORX62141.1 - 0.0064 16.6 0.0 0.013 15.6 0.0 1.5 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 ORX62141.1 - 0.032 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ORX62141.1 - 0.054 13.6 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 ORX62141.1 - 0.069 13.7 0.1 0.26 11.9 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent ThiF PF00899.21 ORX62141.1 - 0.098 12.0 0.6 0.17 11.2 0.6 1.3 1 0 0 1 1 1 0 ThiF family E1_DerP2_DerF2 PF02221.15 ORX62142.1 - 2.1e-11 44.4 0.1 2.8e-11 44.0 0.1 1.1 1 0 0 1 1 1 1 ML domain PP2C PF00481.21 ORX62143.1 - 5.2e-23 82.0 0.0 1.3e-21 77.4 0.0 2.2 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ORX62143.1 - 0.0018 18.2 0.0 0.32 10.9 0.0 2.7 2 1 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) tRNA-synt_2c PF01411.19 ORX62144.1 - 2.1e-213 709.9 0.0 2.8e-213 709.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ORX62144.1 - 7.9e-17 61.1 0.4 2.3e-16 59.6 0.2 1.9 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 ORX62144.1 - 1.2e-13 51.6 5.8 1.2e-13 51.6 5.8 1.9 2 0 0 2 2 2 1 DHHA1 domain PilJ PF13675.6 ORX62144.1 - 0.18 11.8 1.7 0.44 10.6 1.7 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term CP12 PF02672.15 ORX62144.1 - 0.78 10.5 3.5 1.2 9.9 0.4 2.6 2 0 0 2 2 2 0 CP12 domain Kinesin PF00225.23 ORX62146.1 - 1.2e-114 382.7 0.3 1.2e-114 382.7 0.3 2.5 3 1 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ORX62146.1 - 2.6e-28 98.8 0.5 1.3e-27 96.6 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding CPSase_sm_chain PF00988.22 ORX62147.1 - 4.7e-49 165.5 0.0 7.2e-49 164.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 ORX62147.1 - 3.6e-44 150.8 0.0 4.9e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ORX62147.1 - 2.3e-05 24.2 0.3 0.38 10.5 0.1 2.8 2 1 1 3 3 3 2 Peptidase C26 DJ-1_PfpI PF01965.24 ORX62147.1 - 0.0027 17.5 0.0 0.0063 16.3 0.0 1.5 2 0 0 2 2 2 1 DJ-1/PfpI family Dynactin PF12455.8 ORX62149.1 - 5.5e-86 288.3 7.6 5.5e-86 288.3 7.6 3.5 4 1 1 5 5 5 1 Dynein associated protein CAP_GLY PF01302.25 ORX62149.1 - 3.3e-25 87.9 0.6 5.5e-25 87.2 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain MCD_N PF17408.2 ORX62149.1 - 0.63 10.2 4.5 7.1 6.8 4.5 2.9 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase N-terminal domain Hydrolase_6 PF13344.6 ORX62150.1 - 1.1e-18 67.2 0.0 3.2e-18 65.7 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX62150.1 - 1.9e-15 56.6 0.0 3.9e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX62150.1 - 1.8e-05 25.2 0.1 0.00018 21.9 0.1 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX62150.1 - 0.0018 18.4 0.0 0.23 11.5 0.0 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase FleQ PF06490.11 ORX62150.1 - 0.1 13.0 0.1 0.24 11.8 0.1 1.7 1 1 0 1 1 1 0 Flagellar regulatory protein FleQ NARP1 PF12569.8 ORX62151.1 - 9.8e-181 602.1 23.3 9.8e-181 602.1 23.3 1.9 2 0 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 ORX62151.1 - 7.9e-18 63.1 21.5 6.4e-05 22.8 0.4 8.6 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62151.1 - 1.1e-13 51.5 13.3 0.0068 16.9 0.1 7.9 7 1 1 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62151.1 - 3.5e-13 49.2 5.4 0.068 14.0 0.0 9.3 7 2 3 10 10 9 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX62151.1 - 1.7e-09 37.4 1.3 0.11 13.0 0.0 6.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ORX62151.1 - 3.2e-08 33.1 20.1 0.01 15.6 0.8 7.1 8 1 0 8 8 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62151.1 - 9.7e-08 31.7 15.5 0.023 14.9 0.4 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX62151.1 - 1.1e-07 31.9 4.8 0.11 12.6 0.0 5.7 6 2 2 8 8 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62151.1 - 1e-06 28.8 15.0 0.055 13.7 0.0 6.7 4 2 0 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ORX62151.1 - 1.1e-06 29.1 4.0 3 8.6 0.1 7.1 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62151.1 - 1.3e-06 28.6 16.9 0.49 10.7 0.1 7.4 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62151.1 - 2.6e-06 27.0 3.3 0.0057 16.3 0.2 4.9 4 1 1 5 5 5 1 TPR repeat HrpB1_HrpK PF09613.10 ORX62151.1 - 2.4e-05 24.0 4.2 0.19 11.3 0.1 4.1 3 1 1 4 4 4 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_15 PF13429.6 ORX62151.1 - 0.00017 20.9 7.2 0.0077 15.5 0.0 4.2 2 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62151.1 - 0.00029 20.6 0.8 1.3 9.3 0.0 4.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62151.1 - 0.0049 17.4 17.4 31 5.5 0.2 8.6 9 0 0 9 9 8 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ORX62151.1 - 0.012 15.6 12.6 2 8.5 0.7 4.9 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ORX62151.1 - 0.015 15.1 7.2 42 4.2 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ORX62151.1 - 0.02 14.9 7.5 0.18 11.8 1.2 4.3 3 2 0 3 3 3 0 Putative TPR-like repeat BTAD PF03704.17 ORX62151.1 - 0.1 13.0 7.8 2.1 8.8 0.0 4.1 5 0 0 5 5 5 0 Bacterial transcriptional activator domain Wzy_C_2 PF11846.8 ORX62151.1 - 0.13 12.2 2.7 1.1 9.2 0.1 3.2 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal TP_methylase PF00590.20 ORX62151.1 - 0.35 10.8 2.5 0.46 10.4 0.9 2.0 2 0 0 2 2 2 0 Tetrapyrrole (Corrin/Porphyrin) Methylases TPR_MalT PF17874.1 ORX62151.1 - 2.2 7.6 6.7 7.4 5.8 0.3 3.3 3 1 2 5 5 5 0 MalT-like TPR region DUF1279 PF06916.13 ORX62152.1 - 1.2e-16 61.1 0.0 1.9e-16 60.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Aminotran_5 PF00266.19 ORX62153.1 - 9.5e-27 93.9 0.0 1.2e-26 93.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ORX62153.1 - 3.2e-05 22.6 0.0 4.7e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ORX62153.1 - 0.0011 18.2 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Pkinase PF00069.25 ORX62154.1 - 2.3e-65 220.6 0.0 2.9e-65 220.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62154.1 - 1.7e-39 135.7 0.0 2.5e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX62154.1 - 4.4e-07 29.5 0.2 6.9e-07 28.8 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX62154.1 - 1.5e-06 28.3 1.6 0.00051 20.0 0.3 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX62154.1 - 0.00012 21.5 0.0 0.00043 19.7 0.0 1.8 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX62154.1 - 0.00015 20.8 0.0 0.00022 20.3 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ORX62154.1 - 0.00077 19.1 0.1 0.0012 18.5 0.1 1.3 1 0 0 1 1 1 1 RIO1 family Peptidase_S78 PF04586.17 ORX62154.1 - 0.01 16.0 0.1 0.14 12.3 0.0 2.3 2 0 0 2 2 2 0 Caudovirus prohead serine protease Pkinase_fungal PF17667.1 ORX62154.1 - 0.024 13.4 0.0 0.04 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Choline_kinase PF01633.20 ORX62154.1 - 0.025 14.2 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TPR_1 PF00515.28 ORX62155.1 - 8.7e-06 25.3 4.9 0.048 13.5 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62155.1 - 1.1e-05 25.1 10.0 0.0018 18.3 0.1 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62155.1 - 0.0014 18.8 5.4 0.01 16.1 0.5 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62155.1 - 0.0021 18.1 0.6 0.47 10.8 0.2 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat DnaJ PF00226.31 ORX62155.1 - 0.0037 17.4 0.2 0.011 15.9 0.0 1.9 2 0 0 2 2 2 1 DnaJ domain TPR_14 PF13428.6 ORX62155.1 - 0.026 15.3 7.0 0.06 14.2 1.5 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX62155.1 - 0.028 15.1 2.2 4.6 8.0 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62155.1 - 0.095 12.4 0.7 19 5.1 0.2 2.6 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 ORX62155.1 - 0.15 12.2 2.7 1.2 9.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 ORX62155.1 - 0.44 9.4 6.5 0.41 9.5 0.3 2.5 2 1 1 3 3 3 0 NMDA receptor-regulated protein 1 Phosphodiest PF01663.22 ORX62158.1 - 1.5e-78 264.9 0.8 3.4e-78 263.7 0.8 1.5 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ORX62158.1 - 0.00098 18.6 0.0 0.002 17.5 0.0 1.5 2 0 0 2 2 2 1 Metalloenzyme superfamily PglZ PF08665.12 ORX62158.1 - 0.0019 18.3 0.0 0.004 17.3 0.0 1.6 2 0 0 2 2 2 1 PglZ domain Sulfatase PF00884.23 ORX62158.1 - 0.007 15.8 0.5 0.14 11.5 0.5 2.8 1 1 0 1 1 1 1 Sulfatase Mito_carr PF00153.27 ORX62159.1 - 1e-57 192.0 3.1 3.4e-21 75.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein LapA_dom PF06305.11 ORX62159.1 - 0.012 15.4 0.0 16 5.4 0.0 3.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain HMD PF03201.16 ORX62159.1 - 0.024 14.8 0.1 15 5.9 0.0 3.1 3 1 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Sun2_CC2 PF18580.1 ORX62159.1 - 0.057 13.6 0.4 5.5 7.3 0.0 3.1 3 0 0 3 3 3 0 SUN2 coiled coil domain 2 RRM_1 PF00076.22 ORX62160.1 - 2.9e-44 148.7 0.1 1.1e-20 73.2 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 ORX62160.1 - 9.3e-18 65.1 0.8 3e-17 63.5 0.8 1.9 1 1 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_occluded PF16842.5 ORX62160.1 - 5.8e-08 32.5 0.0 0.02 14.7 0.0 3.1 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_3 PF08777.11 ORX62160.1 - 0.00025 21.0 0.0 0.046 13.8 0.0 3.2 3 1 0 3 3 3 1 RNA binding motif Nup35_RRM_2 PF14605.6 ORX62160.1 - 0.0059 16.6 0.1 4.3 7.4 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ORX62160.1 - 0.0099 16.0 0.1 0.13 12.4 0.0 2.4 2 1 0 2 2 2 1 RNA recognition motif RRM_8 PF11835.8 ORX62160.1 - 0.032 14.4 0.0 0.16 12.2 0.0 2.1 2 0 0 2 2 2 0 RRM-like domain Limkain-b1 PF11608.8 ORX62160.1 - 0.04 14.0 0.1 21 5.2 0.0 2.9 3 0 0 3 3 3 0 Limkain b1 Nup35_RRM PF05172.13 ORX62160.1 - 0.075 13.0 0.0 0.3 11.1 0.0 2.0 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 ORX62160.1 - 0.096 12.3 0.0 1.9 8.1 0.0 2.6 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spem1 PF15670.5 ORX62160.1 - 2.7 7.5 7.6 4.1 6.9 7.6 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 TMEM138 PF14935.6 ORX62161.1 - 0.0055 17.4 0.2 0.0065 17.1 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 138 SH3_1 PF00018.28 ORX62162.1 - 3.2e-38 129.1 7.1 1.1e-14 53.8 0.3 3.2 3 0 0 3 3 3 3 SH3 domain SH3_9 PF14604.6 ORX62162.1 - 7.5e-34 115.4 2.5 7.1e-12 45.0 0.0 3.2 3 0 0 3 3 3 3 Variant SH3 domain SH3_2 PF07653.17 ORX62162.1 - 4.1e-29 100.0 0.1 1.5e-09 37.4 0.1 3.3 3 0 0 3 3 3 3 Variant SH3 domain SH3_10 PF17902.1 ORX62162.1 - 0.00052 20.0 0.2 0.012 15.7 0.1 2.6 2 0 0 2 2 2 1 SH3 domain SH3_3 PF08239.11 ORX62162.1 - 3 8.2 7.1 1.7 9.0 0.1 3.1 3 0 0 3 3 3 0 Bacterial SH3 domain PHP PF02811.19 ORX62163.1 - 8.6e-06 26.2 0.0 1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 PHP domain FtsX PF02687.21 ORX62163.1 - 0.074 13.5 1.5 2.1 8.9 0.0 2.3 2 0 0 2 2 2 0 FtsX-like permease family Ribosomal_L7Ae PF01248.26 ORX62164.1 - 3.2e-23 81.3 1.7 6.4e-23 80.3 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATPase_2 PF01637.18 ORX62164.1 - 0.027 14.4 2.0 0.043 13.7 2.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea KAP_NTPase PF07693.14 ORX62164.1 - 0.07 12.4 0.5 0.44 9.7 0.1 1.9 2 0 0 2 2 2 0 KAP family P-loop domain UPF0220 PF05255.11 ORX62165.1 - 1.7e-49 167.6 1.9 1.9e-49 167.4 1.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF2976 PF11190.8 ORX62165.1 - 0.68 9.8 0.1 0.68 9.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) RasGAP PF00616.19 ORX62167.1 - 7.3e-60 202.2 0.1 1.9e-59 200.9 0.1 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX62167.1 - 3.8e-38 130.7 2.1 5.5e-38 130.2 0.7 2.1 2 0 0 2 2 2 1 RasGAP C-terminus CTK3 PF12243.8 ORX62167.1 - 0.018 15.1 0.2 0.38 10.8 0.0 3.0 2 1 0 2 2 2 0 CTD kinase subunit gamma CTK3 Methyltransf_32 PF13679.6 ORX62167.1 - 0.033 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain DUF3198 PF11433.8 ORX62167.1 - 0.071 13.0 0.0 1.3 9.0 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3198) DUF4047 PF13256.6 ORX62167.1 - 0.14 12.4 0.3 0.44 10.8 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) DUF1507 PF07408.11 ORX62167.1 - 6 6.8 6.1 2.6 8.0 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1507) Glyco_transf_20 PF00982.21 ORX62168.1 - 3.2e-198 659.2 0.0 4.2e-198 658.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX62168.1 - 4.9e-54 182.9 0.0 1.2e-53 181.6 0.0 1.7 1 1 0 1 1 1 1 Trehalose-phosphatase Hydrolase_3 PF08282.12 ORX62168.1 - 5.6e-07 29.6 0.0 7.6e-06 25.9 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Glyco_trans_1_4 PF13692.6 ORX62168.1 - 0.0018 18.7 0.0 0.0046 17.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Peptidase_C48 PF02902.19 ORX62170.1 - 2.9e-13 50.1 0.3 3.4e-13 50.0 0.3 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C48 PF02902.19 ORX62171.1 - 1.6e-10 41.2 0.1 1.8e-10 41.1 0.1 1.1 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain GFO_IDH_MocA PF01408.22 ORX62172.1 - 6.6e-23 81.8 0.0 1.2e-22 80.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold F420_oxidored PF03807.17 ORX62172.1 - 0.0004 20.9 0.0 0.00074 20.0 0.0 1.4 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_3 PF03447.16 ORX62172.1 - 0.0029 18.3 0.0 0.0043 17.7 0.0 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain IF-2B PF01008.17 ORX62173.1 - 4.1e-79 265.7 0.0 5.9e-79 265.2 0.0 1.2 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1308 PF07000.11 ORX62173.1 - 0.025 14.5 0.5 0.052 13.5 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) Med14 PF08638.11 ORX62173.1 - 0.092 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit MED14 Ribosomal_L32p PF01783.23 ORX62174.1 - 1.9e-16 60.1 9.6 2.5e-16 59.7 9.6 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family Zn-ribbon_8 PF09723.10 ORX62174.1 - 0.9 9.7 4.4 1.2 9.3 0.4 2.2 1 1 1 2 2 2 0 Zinc ribbon domain PAP_assoc PF03828.19 ORX62176.1 - 6.3e-06 26.3 0.0 2.9e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ORX62176.1 - 0.00013 22.2 0.0 0.0004 20.6 0.0 1.9 1 1 0 1 1 1 1 Nucleotidyltransferase domain Nrap_D2 PF17403.2 ORX62176.1 - 0.00055 19.7 0.0 0.00095 19.0 0.0 1.3 1 0 0 1 1 1 1 Nrap protein PAP/OAS-like domain tRNA_NucTransf2 PF09249.11 ORX62176.1 - 0.018 15.3 0.0 0.058 13.6 0.0 1.8 1 1 0 1 1 1 0 tRNA nucleotidyltransferase, second domain Polbeta PF18765.1 ORX62176.1 - 0.029 14.5 0.0 0.056 13.5 0.0 1.5 1 1 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Patched PF02460.18 ORX62177.1 - 1.4e-78 264.8 13.2 2.3e-77 260.8 13.2 2.0 1 1 0 1 1 1 1 Patched family NPC1_N PF16414.5 ORX62177.1 - 1.5e-73 247.4 5.5 2.1e-73 246.9 5.5 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 ORX62177.1 - 4.3e-50 169.5 7.7 4.3e-50 169.5 7.7 2.5 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 ORX62177.1 - 2.8e-08 33.1 1.3 2.8e-08 33.1 1.3 2.6 2 0 0 2 2 2 1 MMPL family ACR_tran PF00873.19 ORX62177.1 - 0.12 10.0 17.6 0.027 12.2 14.2 1.5 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family PHD PF00628.29 ORX62178.1 - 9.6e-07 28.6 3.9 9.6e-07 28.6 3.9 1.8 2 0 0 2 2 2 1 PHD-finger GATA PF00320.27 ORX62178.1 - 5.7e-05 22.6 5.3 5.7e-05 22.6 5.3 1.9 2 0 0 2 2 2 1 GATA zinc finger zf-PHD-like PF15446.6 ORX62178.1 - 0.0038 16.9 0.7 0.0079 15.8 0.7 1.5 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain zf-rbx1 PF12678.7 ORX62178.1 - 0.0059 16.9 0.6 0.013 15.7 0.6 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-HC5HC2H PF13771.6 ORX62178.1 - 0.013 15.7 0.1 0.013 15.7 0.1 2.0 2 1 0 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ORX62178.1 - 0.056 13.6 1.1 0.24 11.6 0.1 2.1 2 0 0 2 2 2 0 PHD-zinc-finger like domain C1_1 PF00130.22 ORX62178.1 - 0.06 13.2 5.1 0.073 13.0 0.3 2.8 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4629 PF15442.6 ORX62178.1 - 0.089 13.0 1.0 0.15 12.2 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) zf-MYND PF01753.18 ORX62178.1 - 0.41 10.8 4.5 0.53 10.4 0.2 2.9 2 1 0 2 2 2 0 MYND finger PRP38 PF03371.15 ORX62179.1 - 7.9e-59 198.4 0.1 9.1e-59 198.2 0.1 1.0 1 0 0 1 1 1 1 PRP38 family Phage_Coat_A PF05357.13 ORX62180.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Phage Coat Protein A DUF2607 PF10795.9 ORX62180.1 - 0.12 12.5 9.4 0.54 10.4 1.7 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2607) F-box-like PF12937.7 ORX62180.1 - 0.14 12.1 1.6 1.3 9.0 0.1 3.0 3 0 0 3 3 3 0 F-box-like Peptidase_C1_2 PF03051.15 ORX62181.1 - 5.7e-157 523.0 4.5 6.3e-157 522.8 4.5 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 ORX62181.1 - 3.6e-06 27.2 0.1 0.0021 18.2 0.1 2.3 2 0 0 2 2 2 2 Papain family cysteine protease FAD_binding_1 PF00667.20 ORX62182.1 - 2.3e-41 141.8 0.0 3.4e-41 141.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 ORX62182.1 - 4.1e-28 98.4 0.0 7.7e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 ORX62182.1 - 1.1e-13 51.7 0.0 4.6e-13 49.8 0.0 2.0 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_3 PF12641.7 ORX62182.1 - 0.03 14.0 0.0 0.051 13.3 0.0 1.4 1 0 0 1 1 1 0 Flavodoxin domain zf-C2H2_jaz PF12171.8 ORX62183.1 - 1e-07 32.0 2.4 1.7e-07 31.3 0.7 2.1 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX62183.1 - 1.5e-06 28.4 1.7 2.1e-06 27.9 0.6 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-DBF PF07535.12 ORX62183.1 - 0.00012 22.1 0.3 0.00024 21.2 0.3 1.4 1 0 0 1 1 1 1 DBF zinc finger SNRNP27 PF08648.12 ORX62183.1 - 0.00031 20.7 1.0 0.00031 20.7 1.0 2.3 2 0 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins zf_C2H2_ZHX PF18387.1 ORX62183.1 - 0.016 14.8 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_4 PF13894.6 ORX62183.1 - 0.019 15.8 0.9 0.034 15.0 0.2 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger UNC-79 PF14776.6 ORX62183.1 - 0.032 13.0 4.5 0.038 12.7 4.5 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Caldesmon PF02029.15 ORX62183.1 - 0.09 11.5 28.6 0.12 11.2 28.6 1.0 1 0 0 1 1 1 0 Caldesmon zf-U1 PF06220.12 ORX62183.1 - 0.16 11.8 0.3 0.34 10.7 0.3 1.5 1 0 0 1 1 1 0 U1 zinc finger DUF2871 PF11070.8 ORX62184.1 - 0.019 15.2 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) 7tm_6 PF02949.20 ORX62184.1 - 0.037 13.1 0.1 0.056 12.5 0.1 1.2 1 0 0 1 1 1 0 7tm Odorant receptor DUF4495 PF14906.6 ORX62185.1 - 0.023 13.8 0.0 0.026 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4495) STE PF02200.16 ORX62188.1 - 0.013 15.9 0.3 0.044 14.2 0.3 1.8 1 1 0 1 1 1 0 STE like transcription factor F-box-like PF12937.7 ORX62189.1 - 0.0003 20.6 0.5 0.0003 20.6 0.5 2.8 2 0 0 2 2 2 1 F-box-like Usp PF00582.26 ORX62190.1 - 5.3e-15 56.2 0.0 2.1e-14 54.2 0.0 2.0 2 1 0 2 2 2 1 Universal stress protein family DUF442 PF04273.13 ORX62190.1 - 0.022 14.8 0.9 0.051 13.7 0.1 1.9 2 0 0 2 2 2 0 Putative phosphatase (DUF442) zf-C3HC4 PF00097.25 ORX62191.1 - 1.2e-10 41.1 7.5 2e-10 40.4 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX62191.1 - 2e-09 37.6 8.9 3.1e-09 37.0 8.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ORX62191.1 - 2.1e-09 37.1 8.7 4.1e-09 36.1 8.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX62191.1 - 4.5e-09 36.2 6.4 1.3e-08 34.7 6.4 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ORX62191.1 - 1.1e-08 34.8 7.7 1.8e-08 34.1 7.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX62191.1 - 2.2e-08 33.9 6.7 3.5e-08 33.3 6.7 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ORX62191.1 - 4.1e-06 26.8 7.9 6.7e-06 26.2 7.9 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Baculo_IE-1 PF05290.11 ORX62191.1 - 1.1e-05 25.4 4.6 1.8e-05 24.7 4.6 1.2 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) Prok-RING_4 PF14447.6 ORX62191.1 - 1.4e-05 24.9 9.2 2.2e-05 24.2 9.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ORX62191.1 - 0.00011 22.4 7.6 0.00027 21.2 7.6 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ORX62191.1 - 0.0015 18.6 5.6 0.0026 17.8 5.6 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX62191.1 - 0.02 14.5 8.5 0.032 13.8 8.5 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Rtf2 PF04641.12 ORX62191.1 - 0.11 11.8 0.3 0.18 11.2 0.3 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1244 PF06844.11 ORX62191.1 - 0.16 12.1 0.5 0.29 11.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) RINGv PF12906.7 ORX62191.1 - 0.21 11.7 5.3 0.83 9.8 5.3 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_6 PF14835.6 ORX62191.1 - 0.32 10.9 4.7 0.63 10.0 4.7 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ORX62191.1 - 1.2 9.0 7.3 2.8 7.8 6.9 1.8 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Ras PF00071.22 ORX62192.1 - 2.3e-11 43.6 0.3 0.00019 21.1 0.0 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ORX62192.1 - 3.3e-07 30.6 0.9 3.3e-06 27.3 0.2 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX62192.1 - 0.0033 16.9 0.1 0.018 14.5 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 ORX62192.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Kinesin PF00225.23 ORX62193.1 - 4.5e-103 344.7 0.8 5.5e-103 344.4 0.8 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ORX62193.1 - 1e-22 80.7 0.1 1.7e-22 80.0 0.1 1.3 1 0 0 1 1 1 1 Microtubule binding Urease_beta PF00699.20 ORX62193.1 - 0.029 14.4 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 Urease beta subunit BicD PF09730.9 ORX62194.1 - 0.16 10.4 26.8 0.18 10.2 26.1 1.4 1 1 0 1 1 1 0 Microtubule-associated protein Bicaudal-D LMBR1 PF04791.16 ORX62194.1 - 0.3 9.9 15.3 0.39 9.6 15.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ORX62194.1 - 0.9 8.8 21.1 1.3 8.3 21.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TFIIA PF03153.13 ORX62194.1 - 3.9 7.4 21.8 4.6 7.1 21.8 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_POL_M_15KD PF02150.16 ORX62195.1 - 2e-13 49.9 6.9 6e-12 45.2 3.3 2.4 2 0 0 2 2 2 2 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 ORX62195.1 - 1.5e-11 44.0 1.7 1.5e-11 44.0 1.7 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) Anti-TRAP PF15777.5 ORX62195.1 - 0.029 14.3 0.2 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zf_C2H2_10 PF18414.1 ORX62195.1 - 0.44 10.1 4.4 0.57 9.8 0.7 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger Ogr_Delta PF04606.12 ORX62195.1 - 0.73 9.9 7.2 1.2 9.1 3.5 2.7 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger DUF3716 PF12511.8 ORX62195.1 - 0.74 9.9 9.2 0.16 12.0 1.9 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF3716) OrfB_Zn_ribbon PF07282.11 ORX62195.1 - 2.5 8.1 7.7 0.79 9.7 0.7 2.5 2 1 1 3 3 3 0 Putative transposase DNA-binding domain Methyltransf_23 PF13489.6 ORX62196.1 - 0.0001 22.2 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX62196.1 - 0.00013 22.5 0.0 0.00023 21.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX62196.1 - 0.00075 20.2 0.0 0.0014 19.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX62196.1 - 0.0032 18.2 0.0 0.0061 17.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX62196.1 - 0.0039 17.0 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain UQ_con PF00179.26 ORX62197.1 - 7.5e-48 161.7 0.0 8.4e-48 161.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX62197.1 - 0.0016 18.1 0.0 0.002 17.8 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ORX62197.1 - 0.027 14.3 0.0 0.052 13.4 0.0 1.5 1 1 0 1 1 1 0 UEV domain Whi5 PF08528.11 ORX62198.1 - 1.2e-08 34.4 1.3 1.9e-08 33.7 1.3 1.4 1 0 0 1 1 1 1 Whi5 like HLH PF00010.26 ORX62199.1 - 3.8e-10 39.6 0.0 2.7e-09 36.8 0.0 2.5 2 1 0 2 2 2 1 Helix-loop-helix DNA-binding domain DEAD PF00270.29 ORX62200.1 - 7.1e-46 156.2 0.0 1.6e-44 151.8 0.0 2.6 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX62200.1 - 4.4e-29 101.1 0.0 1.1e-27 96.6 0.0 3.0 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 ORX62200.1 - 1e-05 25.6 0.0 0.00013 22.1 0.0 2.5 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit zf-CCHC PF00098.23 ORX62200.1 - 0.0012 18.8 2.9 0.0022 18.0 2.9 1.4 1 0 0 1 1 1 1 Zinc knuckle CxC3 PF18804.1 ORX62200.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases zf-CCHC_4 PF14392.6 ORX62200.1 - 0.12 12.1 0.8 0.36 10.6 0.8 1.8 1 0 0 1 1 1 0 Zinc knuckle AAA_22 PF13401.6 ORX62200.1 - 0.13 12.5 0.0 9.6 6.5 0.0 3.1 2 1 0 2 2 2 0 AAA domain zf-CCHC_2 PF13696.6 ORX62200.1 - 0.17 11.7 2.3 0.44 10.4 2.3 1.7 1 0 0 1 1 1 0 Zinc knuckle ACOX PF01756.19 ORX62201.1 - 1.5e-48 164.7 0.0 2.8e-48 163.9 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 ORX62201.1 - 1.8e-20 73.0 0.0 3.4e-20 72.0 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 ORX62201.1 - 7.8e-15 55.5 0.1 3.6e-14 53.4 0.1 2.1 2 0 0 2 2 2 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 ORX62201.1 - 3.3e-07 30.6 0.2 2.8e-06 27.6 0.2 2.2 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain PAM2 PF07145.15 ORX62202.1 - 0.015 15.0 1.0 0.015 15.0 1.0 1.7 2 0 0 2 2 2 0 Ataxin-2 C-terminal region DUF3759 PF12585.8 ORX62203.1 - 3.5e-21 75.0 8.6 9.8e-21 73.6 8.6 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) RicinB_lectin_2 PF14200.6 ORX62203.1 - 2.5e-05 24.9 0.0 0.035 14.8 0.0 2.7 2 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ORX62203.1 - 9.6e-05 22.6 0.0 0.00065 20.0 0.0 2.1 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain RNA_pol_Rpc4 PF05132.14 ORX62204.1 - 9.6e-25 87.8 1.4 9.6e-25 87.8 1.4 2.9 3 1 0 3 3 3 1 RNA polymerase III RPC4 Pinin_SDK_N PF04697.13 ORX62204.1 - 0.39 11.3 4.5 3.3 8.4 0.6 2.7 2 0 0 2 2 2 0 pinin/SDK conserved region PIG-L PF02585.17 ORX62205.1 - 8.2e-26 91.2 0.0 1.1e-25 90.7 0.0 1.2 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase P3A PF08727.11 ORX62205.1 - 0.15 11.5 0.0 0.31 10.4 0.0 1.5 1 0 0 1 1 1 0 Poliovirus 3A protein like HMG_box PF00505.19 ORX62206.1 - 6.4e-15 55.3 0.2 1.2e-14 54.4 0.2 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX62206.1 - 7.8e-13 48.8 0.4 1.5e-12 47.9 0.4 1.5 1 0 0 1 1 1 1 HMG-box domain TFIIA PF03153.13 ORX62206.1 - 0.12 12.3 12.0 0.25 11.3 11.9 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit L31 PF09784.9 ORX62206.1 - 8.9 6.8 7.4 1.9 8.9 0.6 2.4 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 Abhydrolase_3 PF07859.13 ORX62207.1 - 2.2e-14 53.9 0.4 1e-13 51.7 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ORX62207.1 - 3.4e-10 39.7 0.0 5.4e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family COesterase PF00135.28 ORX62207.1 - 7.5e-09 35.0 0.0 1.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Carboxylesterase family Hydrolase_4 PF12146.8 ORX62207.1 - 4.6e-08 32.6 0.3 0.00018 20.9 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX62207.1 - 1.1e-07 32.7 1.9 1.7e-07 32.0 1.9 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ORX62207.1 - 2.9e-05 24.0 0.1 0.057 13.2 0.0 2.8 2 1 1 3 3 3 2 Phospholipase/Carboxylesterase Chlorophyllase PF07224.11 ORX62207.1 - 0.00047 19.3 0.0 0.00079 18.5 0.0 1.3 1 1 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.7 ORX62207.1 - 0.00068 18.6 0.0 0.001 18.0 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme BAAT_C PF08840.11 ORX62207.1 - 0.003 17.5 0.0 0.081 12.8 0.0 2.1 1 1 0 1 1 1 1 BAAT / Acyl-CoA thioester hydrolase C terminal LIDHydrolase PF10230.9 ORX62207.1 - 0.006 16.2 0.0 0.0093 15.5 0.0 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_1 PF00561.20 ORX62207.1 - 0.0061 16.2 0.3 0.067 12.8 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold DUF1749 PF08538.10 ORX62207.1 - 0.0088 15.2 0.0 0.024 13.8 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1749) DUF2974 PF11187.8 ORX62207.1 - 0.016 14.8 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) LIP PF03583.14 ORX62207.1 - 0.017 14.4 0.0 0.65 9.3 0.0 2.1 2 0 0 2 2 2 0 Secretory lipase PGAP1 PF07819.13 ORX62207.1 - 0.023 14.4 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein PAF-AH_p_II PF03403.13 ORX62207.1 - 0.068 11.7 0.0 1.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Platelet-activating factor acetylhydrolase, isoform II Lipase_3 PF01764.25 ORX62207.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) Ser_hydrolase PF06821.13 ORX62207.1 - 0.14 12.0 0.2 0.82 9.5 0.2 1.9 1 1 0 1 1 1 0 Serine hydrolase Kelch_5 PF13854.6 ORX62208.1 - 1.7e-17 62.9 0.3 0.0002 21.2 0.0 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ORX62208.1 - 1.6e-15 56.8 0.2 0.00091 19.4 0.0 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ORX62208.1 - 5.7e-13 48.2 0.2 0.0072 15.9 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ORX62208.1 - 1.2e-12 47.2 0.2 0.00013 21.8 0.0 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ORX62208.1 - 2.7e-10 40.1 2.7 0.027 14.5 0.0 4.5 4 1 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX62208.1 - 3.7e-10 39.8 7.3 7.1e-06 26.2 0.0 5.7 5 1 0 5 5 5 1 Galactose oxidase, central domain BTB PF00651.31 ORX62208.1 - 1.1e-09 38.4 0.3 2.1e-09 37.6 0.3 1.4 1 0 0 1 1 1 1 BTB/POZ domain DUF4770 PF15994.5 ORX62208.1 - 0.078 13.2 1.0 0.14 12.3 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF2973 PF11189.8 ORX62208.1 - 0.32 11.1 1.8 0.47 10.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) M_domain PF12938.7 ORX62208.1 - 1.1 9.0 14.3 0.98 9.2 12.3 1.9 2 0 0 2 2 2 0 M domain of GW182 Rhodanese PF00581.20 ORX62209.1 - 1.8e-27 95.9 0.0 1.5e-12 48.0 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain Reo_sigmaC PF04582.12 ORX62209.1 - 0.038 14.3 0.1 0.072 13.4 0.1 1.4 1 0 0 1 1 1 0 Reovirus sigma C capsid protein C-terminal domain DUF382 PF04037.13 ORX62211.1 - 7.3e-32 110.2 1.5 9.7e-32 109.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 ORX62211.1 - 2.8e-15 55.9 3.9 1.1e-14 54.0 4.4 1.8 2 0 0 2 2 2 1 PSP DUF382 PF04037.13 ORX62214.1 - 5.7e-40 136.4 0.4 5.7e-40 136.4 0.4 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF382) PSP PF04046.16 ORX62214.1 - 2.3e-15 56.1 4.4 4.9e-15 55.1 4.4 1.6 1 0 0 1 1 1 1 PSP PH_12 PF16457.5 ORX62215.1 - 7.3e-28 97.8 0.0 5.3e-27 95.0 0.0 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain ELMO_CED12 PF04727.13 ORX62215.1 - 5.7e-26 91.7 0.1 1.3e-25 90.5 0.1 1.7 1 0 0 1 1 1 1 ELMO/CED-12 family DUF3361 PF11841.8 ORX62215.1 - 6.1e-26 91.2 0.1 4.8e-16 59.1 0.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3361) PH_2 PF08458.10 ORX62215.1 - 0.014 15.7 0.0 0.036 14.4 0.0 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region V-ATPase_H_C PF11698.8 ORX62215.1 - 0.086 13.0 0.1 0.55 10.4 0.0 2.2 2 0 0 2 2 2 0 V-ATPase subunit H DUF913 PF06025.12 ORX62215.1 - 0.17 10.8 2.3 2 7.3 0.0 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF913) Pex24p PF06398.11 ORX62215.1 - 0.31 10.0 2.1 0.41 9.6 1.5 1.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Brr6_like_C_C PF10104.9 ORX62216.1 - 3.7e-28 97.9 5.3 4.4e-28 97.7 5.3 1.1 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain DHHC PF01529.20 ORX62216.1 - 4.1 7.5 8.5 10 6.2 8.5 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase Rotamase PF00639.21 ORX62217.1 - 2.6e-25 89.2 0.0 3.3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ORX62217.1 - 9.2e-20 71.3 0.0 1.1e-19 71.1 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 ORX62217.1 - 8.5e-07 29.0 3.6 8.5e-07 29.0 3.6 1.8 2 0 0 2 2 2 1 WW domain Rotamase_2 PF13145.6 ORX62217.1 - 0.0013 19.5 0.0 0.0017 19.2 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain MFS_1 PF07690.16 ORX62218.1 - 1.5e-46 158.9 26.9 1.5e-46 158.9 26.9 1.9 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX62218.1 - 2.9e-09 36.3 9.0 2.9e-09 36.3 9.0 2.9 3 0 0 3 3 3 2 Sugar (and other) transporter OATP PF03137.20 ORX62218.1 - 1.5 7.0 8.5 3.9 5.7 4.0 2.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family HLH PF00010.26 ORX62221.1 - 4.4e-14 52.2 0.9 6.3e-14 51.7 0.2 1.6 1 1 1 2 2 2 1 Helix-loop-helix DNA-binding domain DIX PF00778.17 ORX62221.1 - 0.017 14.9 0.0 0.02 14.7 0.0 1.1 1 0 0 1 1 1 0 DIX domain zf-C2H2 PF00096.26 ORX62223.1 - 3.2e-13 49.3 11.9 6.5e-07 29.5 4.0 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX62223.1 - 7.1e-08 32.6 10.5 0.0016 19.1 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX62223.1 - 1.1e-07 32.0 14.6 1.9e-06 28.0 2.6 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_aberr PF17017.5 ORX62223.1 - 0.0012 19.0 2.6 0.0023 18.1 2.6 1.4 1 0 0 1 1 1 1 Aberrant zinc-finger zf-met PF12874.7 ORX62223.1 - 0.011 16.1 3.7 1.6 9.2 1.7 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-BED PF02892.15 ORX62223.1 - 0.09 12.8 6.3 0.14 12.2 0.8 2.4 2 0 0 2 2 2 0 BED zinc finger FOXP-CC PF16159.5 ORX62223.1 - 0.13 12.9 4.0 0.68 10.6 0.3 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ORX62223.1 - 0.23 11.8 8.8 1.4 9.3 1.5 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ORX62223.1 - 3.5 7.5 14.0 11 5.9 2.5 3.0 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-LYAR PF08790.11 ORX62223.1 - 5.5 7.0 7.3 13 5.8 0.8 2.8 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger LMBR1 PF04791.16 ORX62224.1 - 7.7e-27 94.4 12.4 1.3e-21 77.1 0.4 2.2 1 1 1 2 2 2 2 LMBR1-like membrane protein Mit_ribos_Mrp51 PF11709.8 ORX62225.1 - 9.1e-14 51.8 12.6 7.5e-10 38.9 5.4 4.2 3 1 0 3 3 3 2 Mitochondrial ribosomal protein subunit DUF4817 PF16087.5 ORX62225.1 - 0.14 12.0 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) DUF410 PF04190.13 ORX62228.1 - 1.5e-78 264.1 1.7 1.7e-78 264.0 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF410) Arb1 PF09692.10 ORX62229.1 - 4.3e-51 174.4 0.0 8.5e-42 143.7 0.0 2.0 1 1 1 2 2 2 2 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Ank_4 PF13637.6 ORX62230.1 - 5.7e-21 74.6 2.1 1.6e-08 34.9 0.1 4.0 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX62230.1 - 1.2e-15 57.1 1.7 3.7e-08 33.5 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_2 PF12796.7 ORX62230.1 - 6.9e-14 52.2 0.3 2.6e-11 44.0 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX62230.1 - 8.8e-14 50.3 1.3 7.4e-07 29.0 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ORX62230.1 - 2.2e-10 40.6 0.1 1.3e-05 25.4 0.1 4.3 3 2 2 5 5 5 2 Ankyrin repeats (many copies) SGS PF05002.15 ORX62230.1 - 0.0046 17.0 0.0 0.0068 16.5 0.0 1.3 1 0 0 1 1 1 1 SGS domain DNA_mis_repair PF01119.19 ORX62231.1 - 1.4e-14 53.7 0.0 3.4e-14 52.5 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ORX62231.1 - 1.3e-08 34.8 0.7 2.4e-08 33.9 0.7 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX62231.1 - 5.6e-06 26.8 0.1 1.3e-05 25.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Miga PF10265.9 ORX62231.1 - 0.6 9.0 1.9 0.7 8.8 0.0 1.9 2 0 0 2 2 2 0 Mitoguardin Ribonuclease_T2 PF00445.18 ORX62232.1 - 5.9e-38 130.9 0.2 8.1e-38 130.5 0.2 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family DUF1263 PF06882.12 ORX62232.1 - 0.049 13.7 0.4 0.14 12.2 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1263) REV1_C PF16727.5 ORX62233.1 - 0.054 13.9 0.6 5.7 7.4 0.2 2.2 1 1 1 2 2 2 0 DNA repair protein REV1 C-terminal domain Pex24p PF06398.11 ORX62234.1 - 6.2e-33 114.3 11.8 7.6e-33 114.0 11.8 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin FAM176 PF14851.6 ORX62234.1 - 0.07 12.8 1.3 0.14 11.8 1.3 1.4 1 0 0 1 1 1 0 FAM176 family RNA_pol_I_A49 PF06870.12 ORX62235.1 - 1e-96 324.2 0.2 1.2e-96 324.0 0.2 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor DUF4051 PF13260.6 ORX62235.1 - 2.6 7.9 4.4 1.1e+02 2.6 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4051) Nuf2 PF03800.14 ORX62237.1 - 8.4e-28 97.2 0.9 8.4e-28 97.2 0.9 2.1 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 ORX62237.1 - 8.1e-06 25.9 10.9 8.1e-06 25.9 10.9 4.2 1 1 3 4 4 4 2 Designed helical repeat protein 10 domain MAD PF05557.13 ORX62237.1 - 8.1e-05 21.2 41.6 0.00012 20.7 41.6 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein DUF812 PF05667.11 ORX62237.1 - 0.0024 16.9 32.5 0.0032 16.4 32.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) FPP PF05911.11 ORX62237.1 - 0.0085 14.3 48.3 0.32 9.1 25.4 2.1 1 1 1 2 2 2 2 Filament-like plant protein, long coiled-coil Laminin_II PF06009.12 ORX62237.1 - 0.015 15.3 29.5 0.48 10.4 13.0 3.9 2 2 1 4 4 4 0 Laminin Domain II RWP-RK PF02042.15 ORX62237.1 - 0.54 10.3 2.9 17 5.5 0.1 2.9 2 0 0 2 2 2 0 RWP-RK domain AvrLm4-7 PF18661.1 ORX62237.1 - 0.83 10.7 4.9 0.47 11.5 0.5 2.8 1 1 0 2 2 2 0 Avirulence Effector AvrLm4-7 Tubulin PF00091.25 ORX62238.1 - 1.3e-67 227.8 0.0 1.8e-67 227.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ORX62238.1 - 6.8e-50 168.4 0.0 1.1e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ORX62238.1 - 0.00093 18.9 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Homeodomain PF00046.29 ORX62239.1 - 3e-21 75.0 2.2 5.3e-21 74.2 2.2 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX62239.1 - 0.0013 18.6 0.4 0.0033 17.3 0.1 1.9 2 0 0 2 2 2 1 Homeobox KN domain Arrestin_N PF00339.29 ORX62240.1 - 2.9e-10 40.4 0.0 5.1e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 ORX62240.1 - 0.0021 17.8 0.1 0.0049 16.6 0.0 1.6 2 0 0 2 2 2 1 Arrestin_N terminal like Dynactin_p22 PF07426.11 ORX62241.1 - 1.1e-32 113.1 5.1 1.7e-32 112.6 5.1 1.2 1 0 0 1 1 1 1 Dynactin subunit p22 DUF4162 PF13732.6 ORX62241.1 - 0.11 13.3 0.8 0.95 10.2 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4162) TPR_16 PF13432.6 ORX62242.1 - 3.9e-06 27.4 0.3 0.069 13.8 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62242.1 - 0.00023 21.4 13.9 0.069 13.5 0.3 4.8 4 1 1 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62242.1 - 0.0093 16.2 3.7 0.096 12.9 0.8 3.2 2 2 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ORX62242.1 - 0.013 15.3 10.1 2.1 8.3 0.1 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat RPN7 PF10602.9 ORX62242.1 - 0.095 12.4 2.2 0.19 11.4 0.3 2.3 2 0 0 2 2 2 0 26S proteasome subunit RPN7 TPR_2 PF07719.17 ORX62242.1 - 0.11 12.6 12.9 2.3 8.5 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62242.1 - 0.13 12.9 5.1 14 6.6 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62242.1 - 1 9.5 5.0 61 4.0 0.2 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62242.1 - 1.5 9.4 4.9 0.72 10.4 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat AhpC-TSA PF00578.21 ORX62243.1 - 5.9e-40 136.0 0.2 1.5e-39 134.7 0.0 1.6 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ORX62243.1 - 1.1e-14 54.4 0.0 1.5e-14 54.0 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ORX62243.1 - 5e-13 48.7 0.1 9.7e-13 47.7 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Prefoldin_2 PF01920.20 ORX62244.1 - 7.5e-22 77.3 14.5 7.5e-22 77.3 14.5 1.5 1 1 0 1 1 1 1 Prefoldin subunit DHR10 PF18595.1 ORX62244.1 - 0.0014 18.7 19.5 0.0099 15.9 6.0 2.3 2 1 0 2 2 2 2 Designed helical repeat protein 10 domain EzrA PF06160.12 ORX62244.1 - 0.0044 15.3 4.0 0.0044 15.3 4.0 2.0 1 1 0 2 2 2 1 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 ORX62244.1 - 0.012 16.0 11.7 1.2 9.6 0.9 3.4 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF3727 PF12527.8 ORX62244.1 - 0.03 14.6 1.3 0.077 13.2 0.7 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3727) Occludin_ELL PF07303.13 ORX62244.1 - 0.088 13.5 11.3 0.65 10.8 2.2 2.1 2 0 0 2 2 2 0 Occludin homology domain DUF4600 PF15372.6 ORX62244.1 - 0.1 13.0 15.0 0.26 11.7 3.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) DMPK_coil PF08826.10 ORX62244.1 - 0.12 12.5 19.7 0.059 13.5 7.4 2.2 2 0 0 2 2 2 0 DMPK coiled coil domain like Prefoldin PF02996.17 ORX62244.1 - 0.13 12.2 14.9 10 6.0 14.9 2.5 1 1 0 1 1 1 0 Prefoldin subunit YabA PF06156.13 ORX62244.1 - 0.14 12.8 13.2 0.29 11.8 1.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Cluap1 PF10234.9 ORX62244.1 - 0.16 11.3 14.0 0.038 13.4 4.6 2.0 2 0 0 2 2 2 0 Clusterin-associated protein-1 Spc42p PF11544.8 ORX62244.1 - 0.18 11.8 0.4 0.18 11.8 0.4 3.0 2 2 1 3 3 3 0 Spindle pole body component Spc42p COG5 PF10392.9 ORX62244.1 - 0.19 11.9 7.5 0.26 11.5 1.4 2.2 1 1 0 2 2 2 0 Golgi transport complex subunit 5 NPV_P10 PF05531.12 ORX62244.1 - 0.22 12.0 11.9 0.87 10.1 1.8 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tup_N PF08581.10 ORX62244.1 - 0.51 10.7 13.2 0.24 11.8 2.3 3.0 2 1 1 3 3 3 0 Tup N-terminal DUF1664 PF07889.12 ORX62244.1 - 0.61 10.1 13.4 1.2 9.2 2.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 ORX62244.1 - 0.67 10.0 8.1 0.88 9.6 1.4 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fez1 PF06818.15 ORX62244.1 - 0.69 10.3 16.5 0.25 11.8 3.4 2.1 1 1 1 2 2 2 0 Fez1 Sec34 PF04136.15 ORX62244.1 - 0.82 9.5 12.7 0.13 12.1 2.1 2.1 1 1 0 2 2 2 0 Sec34-like family YojJ PF10372.9 ORX62244.1 - 0.94 9.6 7.2 1.6 8.9 0.6 2.6 2 2 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Csm1_N PF18504.1 ORX62244.1 - 1.5 9.2 18.3 1.8 8.9 5.4 3.3 2 2 1 3 3 3 0 Csm1 N-terminal domain MCU PF04678.13 ORX62244.1 - 1.7 8.7 8.1 13 5.9 8.1 1.9 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Atg14 PF10186.9 ORX62244.1 - 1.9 7.5 16.2 3.4 6.7 16.2 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2203 PF09969.9 ORX62244.1 - 1.9 9.2 7.7 0.92 10.2 4.8 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF724 PF05266.14 ORX62244.1 - 2.2 8.1 15.7 0.54 10.1 5.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) SpecificRecomb PF10136.9 ORX62244.1 - 2.4 6.4 7.3 2.7 6.2 7.3 1.0 1 0 0 1 1 1 0 Site-specific recombinase Spc24 PF08286.11 ORX62244.1 - 2.6 8.3 15.4 1.2 9.4 2.8 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Exonuc_VII_L PF02601.15 ORX62244.1 - 3.2 7.2 11.2 4.4 6.8 11.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 ORX62244.1 - 5.3 6.5 7.0 9.3 5.7 6.5 1.6 1 1 0 1 1 1 0 Allexivirus 40kDa protein Spc7 PF08317.11 ORX62244.1 - 8.5 5.2 20.1 30 3.4 20.1 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Coilin_N PF15862.5 ORX62245.1 - 9.6e-05 22.2 4.7 0.00051 19.9 0.7 2.6 2 0 0 2 2 2 2 Coilin N-terminus DUF4551 PF15087.6 ORX62245.1 - 3.9 6.2 6.8 4.5 6.0 6.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) EMP24_GP25L PF01105.24 ORX62246.1 - 5e-23 82.0 0.1 6e-23 81.7 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Aminotran_5 PF00266.19 ORX62247.1 - 4.5e-29 101.5 0.0 5.7e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 ORX62247.1 - 6.2e-05 22.3 0.0 0.00016 21.0 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class I and II RMMBL PF07521.12 ORX62247.1 - 0.079 12.9 0.1 2 8.4 0.0 2.6 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain Pkinase PF00069.25 ORX62248.1 - 4e-66 223.1 0.1 4.4e-64 216.4 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62248.1 - 8.6e-38 130.1 0.0 4.5e-37 127.7 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX62248.1 - 3.5e-07 29.8 0.1 6.8e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ORX62248.1 - 3.4e-06 26.8 0.8 8.9e-06 25.4 0.2 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 ORX62248.1 - 5.9e-05 23.1 0.1 0.0019 18.2 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX62248.1 - 8.8e-05 22.0 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX62248.1 - 0.0013 17.8 0.0 0.0013 17.8 0.0 1.7 2 0 0 2 2 2 1 Haspin like kinase domain Choline_kinase PF01633.20 ORX62248.1 - 0.019 14.5 0.1 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase Ribosomal_L2_C PF03947.18 ORX62249.1 - 4.3e-46 156.2 4.3 6.6e-46 155.6 4.3 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ORX62249.1 - 3.1e-16 59.1 0.1 8e-16 57.8 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain Ribosomal_L32e PF01655.18 ORX62249.1 - 0.019 15.4 0.7 7.1 7.1 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L32 CK2S PF15011.6 ORX62250.1 - 5.8e-12 45.8 5.3 1e-11 45.0 5.3 1.4 1 0 0 1 1 1 1 Casein Kinase 2 substrate EcoEI_R_C PF08463.10 ORX62250.1 - 0.079 13.1 4.0 0.44 10.7 0.1 2.1 1 1 1 2 2 2 0 EcoEI R protein C-terminal EpuA PF11772.8 ORX62250.1 - 0.23 11.2 0.4 0.36 10.5 0.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta WD40 PF00400.32 ORX62251.1 - 2.8e-43 145.0 23.2 2.1e-05 25.2 0.5 13.5 13 0 0 13 13 13 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62251.1 - 7.3e-07 29.4 8.2 4.5 7.6 0.1 8.2 4 3 5 9 9 9 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX62251.1 - 0.035 13.1 0.8 6.1 5.7 0.0 3.6 2 2 2 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein W_rich_C PF07483.11 ORX62251.1 - 1.4 9.1 4.9 30 4.9 0.0 3.9 2 1 1 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain Asp PF00026.23 ORX62252.1 - 7.5e-56 189.8 1.0 8.9e-56 189.6 1.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ORX62252.1 - 3.3e-08 34.0 0.4 3.5e-07 30.6 0.4 2.2 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ORX62252.1 - 0.0049 17.5 0.2 0.45 11.2 0.0 2.8 2 1 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 ORX62252.1 - 0.043 14.4 0.0 0.62 10.7 0.0 2.6 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease zf_CopZ PF18423.1 ORX62253.1 - 0.034 14.1 0.0 0.036 14.0 0.0 1.1 1 0 0 1 1 1 0 Zinc binding domain HutP PF09021.11 ORX62253.1 - 0.12 12.6 0.0 0.13 12.6 0.0 1.1 1 0 0 1 1 1 0 HutP Alk_phosphatase PF00245.20 ORX62255.1 - 9.2e-66 222.5 0.2 3.4e-65 220.6 0.2 1.7 1 1 0 1 1 1 1 Alkaline phosphatase Sulfatase PF00884.23 ORX62255.1 - 3.2e-07 30.0 3.8 5.6e-06 26.0 3.7 2.3 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ORX62255.1 - 2.7e-06 27.2 0.5 5.4e-06 26.2 0.1 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ORX62255.1 - 0.0052 16.2 0.0 0.012 15.0 0.0 1.6 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF229 PF02995.17 ORX62255.1 - 0.13 10.9 0.4 0.2 10.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) DUF2070 PF09843.9 ORX62256.1 - 7.5 4.7 7.0 9.3 4.4 7.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SLX9 PF15341.6 ORX62257.1 - 5.5e-18 65.6 8.2 8e-18 65.1 8.2 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 Myosin-VI_CBD PF16521.5 ORX62257.1 - 0.061 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Myosin VI cargo binding domain DUF4485 PF14846.6 ORX62257.1 - 0.22 11.6 1.8 0.34 11.0 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) RhoGEF67_u1 PF16615.5 ORX62257.1 - 0.36 11.4 4.4 0.86 10.2 4.4 1.6 1 0 0 1 1 1 0 Unstructured region one on RhoGEF 6 and 7 MaoC_dehydratas PF01575.19 ORX62258.1 - 2.4e-24 85.3 0.0 4.4e-24 84.4 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 ORX62258.1 - 0.0085 16.2 0.0 0.12 12.5 0.0 2.3 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase UCH PF00443.29 ORX62259.1 - 2.3e-42 145.3 0.9 2.9e-42 145.0 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX62259.1 - 1.6e-12 47.7 6.4 4e-12 46.4 6.4 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 ORX62259.1 - 8e-06 25.5 3.6 0.0011 18.5 1.9 2.4 2 0 0 2 2 2 2 Ubiquitin-specific peptidase-like, SUMO isopeptidase Spb1_C PF07780.12 ORX62262.1 - 6.4e-81 271.0 21.8 6.4e-81 271.0 21.8 3.1 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 ORX62262.1 - 1.3e-55 188.3 0.0 2.4e-55 187.4 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 ORX62262.1 - 3e-47 160.5 15.8 3e-47 160.5 15.8 5.1 5 0 0 5 5 5 1 Domain of unknown function (DUF3381) DUF148 PF02520.17 ORX62262.1 - 0.0069 16.5 3.2 0.0069 16.5 3.2 2.4 2 0 0 2 2 2 1 Domain of unknown function DUF148 DUF1542 PF07564.11 ORX62262.1 - 0.013 15.6 4.9 0.013 15.6 4.9 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1542) Surp PF01805.20 ORX62265.1 - 2.7e-15 56.1 0.1 2.7e-15 56.1 0.1 1.7 2 0 0 2 2 2 1 Surp module RRM_1 PF00076.22 ORX62265.1 - 3.6e-13 49.1 0.0 1e-12 47.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 ORX62265.1 - 0.0056 17.5 0.0 0.016 16.0 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CTK3 PF12243.8 ORX62265.1 - 0.14 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 tRNA-synt_1d PF00750.19 ORX62266.1 - 1.3e-86 290.7 0.2 4.8e-85 285.6 0.2 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 ORX62266.1 - 2.8e-21 75.9 0.0 5.1e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 DALR anticodon binding domain Aa_trans PF01490.18 ORX62267.1 - 6.3e-47 160.2 25.8 7.4e-47 160.0 25.8 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein P53_TAD PF08563.11 ORX62267.1 - 0.19 11.2 0.8 0.48 10.0 0.1 2.0 2 0 0 2 2 2 0 P53 transactivation motif RRM_1 PF00076.22 ORX62268.1 - 0.016 15.0 0.9 0.039 13.8 0.6 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NAD_binding_5 PF07994.12 ORX62269.1 - 3.6e-146 486.6 0.0 4.2e-146 486.4 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ORX62269.1 - 1.1e-44 151.1 0.1 2.2e-44 150.2 0.1 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase START PF01852.19 ORX62270.1 - 2.3e-14 53.3 0.0 5.5e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 START domain Glyco_hydro_5_C PF18564.1 ORX62270.1 - 0.0046 17.5 0.1 0.015 15.8 0.1 1.8 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain ubiquitin PF00240.23 ORX62271.1 - 1.9e-20 72.4 1.3 3.5e-20 71.5 1.3 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX62271.1 - 1.2e-08 34.6 0.7 2.3e-08 33.8 0.7 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Blt1 PF12754.7 ORX62271.1 - 2e-06 28.2 3.0 2e-06 28.2 3.0 1.5 1 1 0 1 1 1 1 Blt1 N-terminal domain Rad60-SLD_2 PF13881.6 ORX62271.1 - 0.00042 20.4 0.1 0.0012 18.9 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ORX62271.1 - 0.00075 19.9 1.9 0.0018 18.7 1.3 1.9 2 1 0 2 2 2 1 Ubiquitin-like domain DUF2407 PF10302.9 ORX62271.1 - 0.0019 18.8 1.1 0.0031 18.0 0.5 1.7 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ORX62271.1 - 0.027 14.4 0.2 0.058 13.3 0.2 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Tugs PF17840.1 ORX62271.1 - 0.044 14.0 0.6 0.094 12.9 0.6 1.5 1 0 0 1 1 1 0 Tethering Ubl4a to BAGS domain Sec66 PF09802.9 ORX62272.1 - 2.4e-45 154.3 1.7 2.6e-45 154.2 1.7 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 GLTP PF08718.11 ORX62272.1 - 0.0049 17.2 0.5 0.0079 16.5 0.5 1.4 1 1 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF2877 PF11392.8 ORX62272.1 - 0.13 13.0 0.1 1.3 9.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) CcmF_C PF16327.5 ORX62273.1 - 0.0013 18.1 0.6 0.0013 18.1 0.6 1.9 2 1 0 2 2 2 1 Cytochrome c-type biogenesis protein CcmF C-terminal WD40 PF00400.32 ORX62274.1 - 7.4e-20 70.9 29.4 6.7e-07 29.9 0.3 10.4 11 1 0 11 11 11 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ORX62274.1 - 0.0035 16.4 1.6 2.9 6.8 0.5 3.7 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Imm26 PF15428.6 ORX62275.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 26 WD40 PF00400.32 ORX62275.1 - 0.15 13.0 0.4 2.2 9.3 0.0 2.7 2 1 0 2 2 2 0 WD domain, G-beta repeat Nup160 PF11715.8 ORX62275.1 - 0.17 10.5 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Aminotran_5 PF00266.19 ORX62276.1 - 1.8e-30 106.1 0.1 2.4e-30 105.7 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-V B12-binding PF02310.19 ORX62276.1 - 0.0011 19.0 0.1 0.0021 18.1 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain Aminotran_1_2 PF00155.21 ORX62276.1 - 0.0014 17.9 0.0 0.0064 15.7 0.0 1.8 2 0 0 2 2 2 1 Aminotransferase class I and II KR PF08659.10 ORX62276.1 - 0.086 12.8 0.1 0.15 11.9 0.1 1.4 1 0 0 1 1 1 0 KR domain DegT_DnrJ_EryC1 PF01041.17 ORX62276.1 - 0.13 11.5 1.7 0.22 10.8 1.7 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Asn_synthase PF00733.21 ORX62277.1 - 1.8e-74 251.6 0.0 2.2e-74 251.2 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 ORX62277.1 - 4.7e-40 136.3 0.0 8.5e-40 135.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ORX62277.1 - 2.1e-33 115.3 0.0 3.8e-33 114.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 ORX62277.1 - 0.049 12.8 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 NAD synthase DUF3700 PF12481.8 ORX62277.1 - 0.084 12.3 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 Aluminium induced protein Metallophos_2 PF12850.7 ORX62278.1 - 2e-20 73.6 0.0 2.4e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ORX62278.1 - 1.4e-05 25.7 2.0 0.054 14.0 0.1 2.3 1 1 1 2 2 2 2 Calcineurin-like phosphoesterase Phage_spike PF18715.1 ORX62278.1 - 0.027 14.5 0.1 2.5 8.2 0.0 3.0 2 1 1 3 3 3 0 Phage spike trimer EF-hand_6 PF13405.6 ORX62279.1 - 3.1e-09 36.0 2.1 0.0017 18.1 0.2 2.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ORX62279.1 - 2e-07 30.1 1.5 6.4e-05 22.2 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ORX62279.1 - 3.4e-07 30.6 0.4 1e-06 29.1 0.4 1.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ORX62279.1 - 1.8e-05 24.0 1.2 4.9e-05 22.6 0.1 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ORX62279.1 - 0.002 17.9 0.5 0.11 12.4 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX62279.1 - 0.11 12.9 0.7 0.47 10.8 0.0 2.2 1 1 2 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DMAP_binding PF06464.11 ORX62279.1 - 0.37 11.6 1.8 2.3 9.1 1.8 1.9 1 1 0 1 1 1 0 DMAP1-binding Domain Topoisom_bac PF01131.20 ORX62280.1 - 3.5e-109 365.5 0.0 4.6e-109 365.2 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 ORX62280.1 - 6.5e-15 55.2 0.0 1.1e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Myb_DNA-binding PF00249.31 ORX62281.1 - 1.1e-38 131.1 6.4 3.1e-14 52.9 0.9 3.4 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX62281.1 - 1.7e-32 111.4 0.9 1.5e-13 50.8 0.0 3.4 1 1 2 3 3 3 3 Myb-like DNA-binding domain MADF_DNA_bdg PF10545.9 ORX62281.1 - 0.00014 22.1 4.9 0.031 14.6 1.5 3.3 2 1 1 3 3 3 2 Alcohol dehydrogenase transcription factor Myb/SANT-like Myb_DNA-bind_4 PF13837.6 ORX62281.1 - 0.0023 18.3 7.3 3.5 8.1 3.1 3.5 2 1 1 3 3 3 2 Myb/SANT-like DNA-binding domain SET PF00856.28 ORX62282.1 - 1.7e-14 54.5 0.2 6e-14 52.8 0.1 1.9 2 0 0 2 2 2 1 SET domain HTH_21 PF13276.6 ORX62282.1 - 1.8e-05 24.8 0.0 4.2e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 HTH-like domain zf-MYND PF01753.18 ORX62282.1 - 0.0016 18.5 11.8 0.0016 18.5 11.8 2.4 2 0 0 2 2 2 1 MYND finger Velvet PF11754.8 ORX62284.1 - 3.8e-58 197.4 0.9 1.4e-39 136.5 0.2 2.0 1 1 1 2 2 2 2 Velvet factor TetR_C_4 PF08359.11 ORX62285.1 - 0.078 13.1 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 YsiA-like protein, C-terminal region WW PF00397.26 ORX62286.1 - 6.1e-15 55.0 2.7 1.6e-14 53.7 2.7 1.8 1 0 0 1 1 1 1 WW domain DUF4407 PF14362.6 ORX62286.1 - 0.014 14.8 5.3 0.024 14.0 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Myosin_head PF00063.21 ORX62287.1 - 4.2e-267 887.8 2.9 4.2e-267 887.8 2.9 1.5 2 0 0 2 2 2 1 Myosin head (motor domain) DIL PF01843.19 ORX62287.1 - 4.4e-25 88.0 1.1 4.4e-25 88.0 1.1 3.4 3 0 0 3 3 3 1 DIL domain IQ PF00612.27 ORX62287.1 - 9.8e-12 43.6 28.6 5.1e-05 22.7 1.6 6.5 5 1 0 6 6 6 4 IQ calmodulin-binding motif DUF4795 PF16043.5 ORX62287.1 - 8.3e-05 22.3 3.9 0.00027 20.6 3.9 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) GCN5L1 PF06320.13 ORX62287.1 - 0.0032 17.6 4.0 0.0032 17.6 4.0 2.5 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) AAA_22 PF13401.6 ORX62287.1 - 0.0067 16.7 1.6 0.066 13.5 0.0 3.3 2 1 1 3 3 3 1 AAA domain T2SSE PF00437.20 ORX62287.1 - 0.042 12.9 0.7 0.08 12.0 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 ORX62287.1 - 0.065 12.9 0.0 0.21 11.3 0.0 1.8 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ORX62287.1 - 0.075 13.4 3.5 0.083 13.3 0.0 2.9 3 1 0 3 3 3 0 AAA ATPase domain FlaC_arch PF05377.11 ORX62287.1 - 0.73 10.3 6.6 0.24 11.8 0.8 2.9 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 ORX62287.1 - 2.8 8.2 6.6 3 8.1 1.7 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ABC_tran PF00005.27 ORX62287.1 - 3.2 8.3 8.0 2.6 8.6 0.0 3.6 2 1 1 3 3 3 0 ABC transporter DUF1640 PF07798.11 ORX62288.1 - 1.1e-50 172.1 11.5 1.2e-50 171.9 11.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) HALZ PF02183.18 ORX62288.1 - 0.013 15.8 2.2 0.013 15.8 2.2 2.2 2 1 1 3 3 3 0 Homeobox associated leucine zipper Lectin_N PF03954.14 ORX62288.1 - 0.05 13.3 3.0 0.083 12.6 2.7 1.5 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF4854 PF16146.5 ORX62288.1 - 0.053 13.9 2.8 0.053 13.9 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4854) TLE_N PF03920.15 ORX62288.1 - 0.068 13.3 6.7 3.9 7.6 0.1 2.6 1 1 1 2 2 2 0 Groucho/TLE N-terminal Q-rich domain DUF4407 PF14362.6 ORX62288.1 - 0.077 12.3 5.1 0.088 12.1 5.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Uso1_p115_C PF04871.13 ORX62288.1 - 0.2 12.0 11.7 0.24 11.8 6.8 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Exonuc_VII_L PF02601.15 ORX62288.1 - 0.48 9.9 5.3 0.53 9.8 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 ORX62288.1 - 0.99 9.4 6.3 1.2 9.1 2.5 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlaC_arch PF05377.11 ORX62288.1 - 1.3 9.5 11.2 1.8 9.0 1.4 3.3 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF1616 PF07760.11 ORX62288.1 - 1.4 8.2 4.6 1.6 8.0 4.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) Remorin_C PF03763.13 ORX62288.1 - 1.5 8.8 9.0 2.5 8.0 8.7 1.6 1 1 0 1 1 1 0 Remorin, C-terminal region YlqD PF11068.8 ORX62288.1 - 1.5 9.2 12.9 38 4.7 12.9 2.1 1 1 0 1 1 1 0 YlqD protein YabA PF06156.13 ORX62288.1 - 2.3 8.9 11.2 2.6 8.7 7.4 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Occludin_ELL PF07303.13 ORX62288.1 - 2.7 8.7 8.0 1.8 9.3 3.4 2.1 1 1 1 2 2 2 0 Occludin homology domain Atg14 PF10186.9 ORX62288.1 - 3.5 6.6 10.4 4.7 6.2 10.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CCDC23 PF15674.5 ORX62288.1 - 4.1 7.5 7.1 0.79 9.8 1.9 2.4 2 1 0 3 3 3 0 Coiled-coil domain-containing protein 23 DUF4112 PF13430.6 ORX62289.1 - 3.5e-15 56.1 0.1 4.4e-15 55.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Fungal_trans PF04082.18 ORX62290.1 - 8.1e-34 116.9 0.4 1.8e-33 115.7 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain F-box-like PF12937.7 ORX62291.1 - 1.3e-11 44.2 0.6 5.1e-11 42.3 0.6 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62291.1 - 1.5e-07 31.1 0.2 4.4e-07 29.6 0.2 1.9 1 0 0 1 1 1 1 F-box domain Homeodomain PF00046.29 ORX62292.1 - 4.3e-19 68.1 4.5 7e-19 67.4 4.5 1.4 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX62292.1 - 0.0059 16.5 1.5 0.0086 16.0 0.2 2.0 2 0 0 2 2 2 1 Homeobox KN domain PI3_PI4_kinase PF00454.27 ORX62293.1 - 1.7e-31 109.9 0.1 2.6e-20 73.3 0.0 2.3 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ORX62293.1 - 3e-06 26.8 0.3 7.1e-06 25.5 0.3 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Spore_IV_A PF09547.10 ORX62293.1 - 0.14 11.1 0.0 0.22 10.4 0.0 1.2 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) RRM_1 PF00076.22 ORX62294.1 - 1.8e-16 59.7 0.0 2.2e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX62294.1 - 0.12 12.6 0.0 0.22 11.7 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif Helicase_C_2 PF13307.6 ORX62296.1 - 4.4e-57 193.0 0.0 1.3e-56 191.5 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 ORX62296.1 - 4.2e-51 173.1 1.7 1.1e-50 171.6 1.7 1.8 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 ORX62296.1 - 0.0005 20.1 1.4 0.43 10.6 0.0 3.1 2 1 0 2 2 2 2 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX62296.1 - 0.0026 17.6 0.1 0.46 10.2 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.6 ORX62296.1 - 0.0097 16.2 0.5 0.67 10.2 0.1 3.2 3 0 0 3 3 3 1 AAA domain zf-Mss51 PF13824.6 ORX62298.1 - 0.014 15.4 0.9 1.4 9.1 0.0 2.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Prok-RING_1 PF14446.6 ORX62298.1 - 0.24 11.4 6.3 0.89 9.5 1.1 2.5 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-CCHC_6 PF15288.6 ORX62298.1 - 1 9.3 8.9 5.1 7.0 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle Zn-ribbon_8 PF09723.10 ORX62298.1 - 5.8 7.1 6.0 15 5.8 0.8 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 ORX62298.1 - 7.2 6.7 8.4 1.7e+02 2.3 8.4 2.4 1 1 0 1 1 1 0 Double zinc ribbon F-box-like PF12937.7 ORX62300.1 - 0.0015 18.4 0.7 0.004 17.0 0.7 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62300.1 - 0.033 14.1 0.2 0.13 12.2 0.2 2.0 1 0 0 1 1 1 0 F-box domain CRCB PF02537.15 ORX62301.1 - 5.7e-32 109.9 22.6 1.6e-20 73.2 8.6 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) DUF3099 PF11298.8 ORX62301.1 - 0.22 11.7 1.6 0.69 10.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) DUF2418 PF10332.9 ORX62301.1 - 2.6 8.6 5.2 1.6 9.3 0.1 2.8 2 2 1 3 3 3 0 Protein of unknown function (DUF2418) Acetyltransf_4 PF13420.7 ORX62302.1 - 3.4e-21 76.0 0.0 3.9e-21 75.8 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ORX62302.1 - 5.1e-11 43.4 0.0 6.5e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ORX62302.1 - 6.5e-11 42.5 0.0 8.2e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ORX62302.1 - 1.8e-06 28.2 0.0 2.8e-06 27.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ORX62302.1 - 2.6e-06 27.3 0.0 7.3e-06 25.9 0.0 1.6 1 1 1 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.7 ORX62302.1 - 1.1e-05 25.4 0.0 1.5e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain APG6_N PF17675.1 ORX62303.1 - 0.0014 19.1 8.2 0.0025 18.3 8.2 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region Prefoldin_2 PF01920.20 ORX62303.1 - 0.018 15.0 1.5 0.018 15.0 1.5 2.0 1 1 1 2 2 2 0 Prefoldin subunit GAS PF13851.6 ORX62303.1 - 0.051 12.9 8.0 0.078 12.3 8.0 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Takusan PF04822.13 ORX62303.1 - 0.1 12.5 5.9 0.049 13.5 1.9 2.2 1 1 1 2 2 2 0 Takusan MCD_N PF17408.2 ORX62303.1 - 0.62 10.2 3.3 1.3 9.3 3.3 1.6 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase N-terminal domain V_ATPase_I PF01496.19 ORX62303.1 - 1.1 7.1 7.6 1.4 6.8 7.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 ORX62303.1 - 3.1 7.6 11.0 0.25 11.1 2.6 2.3 1 1 2 3 3 3 0 Septum formation initiator Hydrolase_3 PF08282.12 ORX62304.1 - 0.018 14.8 0.0 0.02 14.6 0.0 1.0 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NDC10_II PF16787.5 ORX62307.1 - 0.031 13.3 0.0 0.031 13.3 0.0 1.1 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit, domain 2 NADase_NGA PF07461.11 ORX62308.1 - 0.077 11.9 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Nicotine adenine dinucleotide glycohydrolase (NADase) ABC_membrane PF00664.23 ORX62311.1 - 2.1e-27 96.5 18.5 3.9e-14 53.0 3.2 2.7 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX62311.1 - 2.4e-14 54.0 0.0 1.1e-05 25.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_33 PF13671.6 ORX62311.1 - 0.0002 21.6 0.0 0.0008 19.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ORX62311.1 - 0.017 15.4 0.3 2.4 8.4 0.0 3.4 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 ORX62311.1 - 0.043 13.6 0.1 0.19 11.5 0.1 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX62311.1 - 0.047 14.1 0.1 0.34 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Lum_binding PF00677.17 ORX62311.1 - 0.2 11.7 0.0 4 7.5 0.0 2.7 1 1 1 2 2 2 0 Lumazine binding domain Ecl1 PF12855.7 ORX62312.1 - 9e-13 49.7 10.7 1.1e-12 49.4 10.7 1.2 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins zf-MYND PF01753.18 ORX62312.1 - 0.0045 17.0 1.4 0.0088 16.1 1.4 1.4 1 0 0 1 1 1 1 MYND finger VATC PF18716.1 ORX62312.1 - 0.53 10.2 2.7 1.1 9.1 2.7 1.5 1 1 0 1 1 1 0 Vms1-associating treble clef domain zf-FLZ PF04570.14 ORX62312.1 - 0.86 9.1 3.4 9.6 5.8 3.4 2.2 1 1 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 7tm_3 PF00003.22 ORX62313.1 - 8.2e-10 38.8 5.8 1.1e-09 38.4 5.8 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR ANF_receptor PF01094.28 ORX62314.1 - 1.5e-34 119.7 0.2 2.3e-34 119.1 0.2 1.3 1 1 0 1 1 1 1 Receptor family ligand binding region Peripla_BP_6 PF13458.6 ORX62314.1 - 1e-13 51.7 1.0 4e-13 49.8 1.6 1.6 2 0 0 2 2 2 1 Periplasmic binding protein Cse1 PF08506.10 ORX62315.1 - 3.9e-146 486.6 1.7 7.9e-146 485.6 1.7 1.5 1 0 0 1 1 1 1 Cse1 CAS_CSE1 PF03378.15 ORX62315.1 - 3.6e-119 398.1 2.5 6.4e-119 397.3 2.5 1.4 1 0 0 1 1 1 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 ORX62315.1 - 2.1e-15 56.4 0.2 2.5e-14 52.9 0.0 2.6 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 ORX62315.1 - 0.0078 16.3 0.4 0.11 12.5 0.0 3.2 2 0 0 2 2 2 1 Exportin 1-like protein Arm PF00514.23 ORX62315.1 - 0.034 14.2 0.1 49 4.2 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 ORX62315.1 - 0.042 13.8 0.3 0.31 10.9 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) WD40 PF00400.32 ORX62316.1 - 1.2e-26 92.4 17.9 1.5e-06 28.9 0.1 6.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62316.1 - 4.7e-13 49.2 0.0 0.0029 17.9 0.1 5.6 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ORX62316.1 - 9.3e-07 28.1 4.9 0.088 11.8 0.0 3.7 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein HIRA_B PF09453.10 ORX62316.1 - 2.4e-05 24.1 10.0 0.63 10.0 0.6 3.5 3 0 0 3 3 3 3 HIRA B motif eIF2A PF08662.11 ORX62316.1 - 0.0032 17.4 0.2 0.2 11.5 0.0 3.5 4 0 0 4 4 4 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ORX62316.1 - 0.0079 16.1 1.7 0.21 11.6 0.4 3.4 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ORX62316.1 - 0.29 10.4 0.0 18 4.5 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain CAP_GLY PF01302.25 ORX62317.1 - 4.9e-19 68.1 0.2 7.5e-19 67.5 0.2 1.3 1 0 0 1 1 1 1 CAP-Gly domain LSM PF01423.22 ORX62318.1 - 3e-17 62.1 0.3 3.8e-17 61.7 0.3 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 ORX62318.1 - 0.055 13.6 0.0 0.097 12.8 0.0 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Ribosomal_S28e PF01200.18 ORX62319.1 - 7.6e-34 115.5 0.9 8.5e-34 115.4 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Phostensin_N PF13916.6 ORX62319.1 - 0.057 13.8 0.0 0.06 13.7 0.0 1.1 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal Sds3 PF08598.11 ORX62320.1 - 1.3e-16 61.3 13.0 3.6e-16 59.8 13.0 1.8 1 1 0 1 1 1 1 Sds3-like GCP_C_terminal PF04130.13 ORX62322.1 - 1.1e-78 264.8 10.3 1.1e-78 264.8 10.3 2.2 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ORX62322.1 - 8e-76 255.6 1.4 2.9e-75 253.7 0.1 2.4 2 1 1 3 3 3 1 Gamma tubulin complex component N-terminal PAP1 PF08601.10 ORX62322.1 - 0.2 11.4 3.6 0.37 10.5 3.6 1.4 1 0 0 1 1 1 0 Transcription factor PAP1 SR-25 PF10500.9 ORX62322.1 - 1.2 8.7 6.6 2.3 7.8 6.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_18 PF00704.28 ORX62323.1 - 6.8e-23 81.9 0.0 1.3e-22 81.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_19 PF03427.13 ORX62323.1 - 0.00028 20.8 5.5 0.00028 20.8 5.5 2.3 2 0 0 2 2 2 1 Carbohydrate binding domain (family 19) D_CNTX PF17492.2 ORX62323.1 - 0.85 9.8 5.0 2.5 8.4 5.0 1.8 1 0 0 1 1 1 0 Delta Ctenitoxins SWIM PF04434.17 ORX62328.1 - 0.07 12.8 0.4 0.14 11.8 0.4 1.5 1 0 0 1 1 1 0 SWIM zinc finger adh_short PF00106.25 ORX62330.1 - 3.8e-59 199.4 0.1 4.8e-59 199.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX62330.1 - 3.7e-45 154.3 0.1 4.6e-45 154.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX62330.1 - 1.2e-14 54.6 0.2 1.6e-14 54.3 0.2 1.1 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ORX62330.1 - 0.0064 15.7 0.0 0.0083 15.3 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Eno-Rase_NADH_b PF12242.8 ORX62330.1 - 0.01 15.5 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Epimerase PF01370.21 ORX62330.1 - 0.022 14.2 0.3 0.045 13.2 0.3 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.20 ORX62330.1 - 0.063 13.3 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Anp1 PF03452.14 ORX62331.1 - 1.2e-91 306.8 0.0 1.5e-91 306.5 0.0 1.0 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 ORX62331.1 - 0.0022 17.8 0.1 0.059 13.2 0.1 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_4 PF13704.6 ORX62331.1 - 0.065 13.7 0.2 0.17 12.4 0.2 1.8 1 1 0 1 1 1 0 Glycosyl transferase family 2 WbqC PF08889.11 ORX62331.1 - 0.1 12.5 0.1 0.28 11.1 0.0 1.7 2 0 0 2 2 2 0 WbqC-like protein family RRM_1 PF00076.22 ORX62332.1 - 1.6e-15 56.6 0.0 2.5e-15 56.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) BORCS7 PF16088.5 ORX62333.1 - 8.8e-12 45.2 3.1 1.1e-11 44.9 3.1 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 7 PilA4 PF18682.1 ORX62333.1 - 0.022 15.1 0.5 0.036 14.4 0.5 1.3 1 0 0 1 1 1 0 Pilin A4 Mito_carr PF00153.27 ORX62334.1 - 5.4e-61 202.5 2.1 3.3e-21 75.0 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX62334.1 - 0.0014 17.9 1.1 0.53 9.4 0.0 3.2 2 1 2 4 4 4 2 Gammaproteobacterial serine protease Sec1 PF00995.23 ORX62335.1 - 4.5e-115 386.1 0.5 5.2e-115 385.9 0.5 1.0 1 0 0 1 1 1 1 Sec1 family 60KD_IMP PF02096.20 ORX62335.1 - 0.03 14.2 0.4 0.053 13.4 0.4 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein OTU PF02338.19 ORX62337.1 - 9.2e-05 22.9 0.0 0.00017 22.1 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease UBX PF00789.20 ORX62337.1 - 0.0047 17.1 0.0 0.0092 16.2 0.0 1.5 1 0 0 1 1 1 1 UBX domain Fungal_trans PF04082.18 ORX62338.1 - 5.2e-37 127.3 0.0 1.4e-36 125.9 0.0 1.8 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 ORX62338.1 - 2.7e-09 37.0 6.5 5e-09 36.1 6.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 ORX62338.1 - 0.001 19.1 1.1 0.054 13.6 0.5 3.2 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 EF_assoc_2 PF08356.12 ORX62339.1 - 1.9e-35 120.7 0.0 4.9e-35 119.4 0.0 1.8 2 0 0 2 2 1 1 EF hand associated EF_assoc_1 PF08355.12 ORX62339.1 - 1.3e-28 98.4 3.3 2.4e-28 97.5 3.3 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 ORX62339.1 - 1.4e-20 73.6 0.0 4.9e-10 39.2 0.0 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ORX62339.1 - 1.1e-10 41.7 0.0 2.1e-05 24.7 0.0 2.7 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase EF-hand_6 PF13405.6 ORX62339.1 - 5.3e-10 38.4 0.1 0.00041 20.1 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ORX62339.1 - 8e-10 37.6 0.7 8.4e-05 21.8 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ORX62339.1 - 6e-09 36.2 0.3 0.005 17.3 0.0 3.0 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ORX62339.1 - 3e-06 26.5 2.1 0.00029 20.2 0.1 2.5 2 0 0 2 2 2 1 EF hand MMR_HSR1 PF01926.23 ORX62339.1 - 6.4e-05 23.0 0.1 0.0004 20.4 0.0 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase EF-hand_10 PF14788.6 ORX62339.1 - 0.0011 18.8 3.8 0.072 13.0 0.1 3.2 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ORX62339.1 - 0.0018 18.1 0.3 2.7 7.9 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair AAA_22 PF13401.6 ORX62339.1 - 0.0033 17.7 0.0 0.02 15.1 0.0 2.3 3 1 0 3 3 2 1 AAA domain Ploopntkinase3 PF18751.1 ORX62339.1 - 0.0092 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 P-loop Nucleotide Kinase3 SPARC_Ca_bdg PF10591.9 ORX62339.1 - 0.024 15.0 0.1 0.72 10.2 0.1 2.5 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_28 PF13521.6 ORX62339.1 - 0.033 14.4 0.0 0.093 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ORX62339.1 - 0.035 14.5 0.0 0.17 12.3 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Fungal_lectin_2 PF18647.1 ORX62339.1 - 0.044 14.3 0.0 0.088 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha-galactosyl-binding fungal lectin ATP_bind_1 PF03029.17 ORX62339.1 - 0.058 13.2 0.5 1.5 8.6 0.0 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF2075 PF09848.9 ORX62339.1 - 0.075 12.3 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) cobW PF02492.19 ORX62339.1 - 0.092 12.3 0.0 0.33 10.5 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 ORX62339.1 - 0.14 12.1 0.0 0.35 10.8 0.0 1.8 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ORX62339.1 - 0.14 12.0 0.5 12 5.7 0.0 3.2 2 1 0 3 3 3 0 RsgA GTPase AAA_30 PF13604.6 ORX62339.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATG7_N PF16420.5 ORX62340.1 - 1.8e-79 267.5 0.0 2.3e-79 267.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ORX62340.1 - 4.4e-44 150.7 0.0 6.3e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ORX62340.1 - 0.017 15.2 0.0 0.32 11.0 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase zf-C2H2 PF00096.26 ORX62341.1 - 2e-12 46.9 13.8 2e-06 27.9 4.0 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX62341.1 - 1.1e-10 41.4 18.7 3.7e-07 30.3 3.6 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX62341.1 - 1.6e-07 31.5 11.4 0.002 18.8 1.6 2.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX62341.1 - 0.00068 19.9 1.3 0.093 13.0 0.3 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX62341.1 - 0.16 12.0 3.9 8.3 6.5 0.1 2.6 2 2 0 2 2 2 0 C2H2-type zinc finger DUF2225 PF09986.9 ORX62341.1 - 0.24 11.1 1.7 0.55 9.9 1.7 1.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_5 PF13909.6 ORX62341.1 - 0.29 10.9 17.6 0.48 10.2 0.2 3.8 4 0 0 4 4 4 0 C2H2-type zinc-finger domain Zn-C2H2_12 PF18112.1 ORX62341.1 - 0.74 10.3 11.2 7.5 7.1 0.1 2.9 2 1 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain Cut8 PF08559.10 ORX62342.1 - 2.1e-45 155.2 3.0 2.8e-45 154.8 3.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Pkinase PF00069.25 ORX62343.1 - 1.4e-59 201.6 0.1 9e-52 176.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62343.1 - 3.3e-33 115.1 0.0 2.1e-29 102.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ORX62343.1 - 4.2e-06 26.3 0.0 8e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX62343.1 - 0.00077 18.3 0.1 0.0019 17.1 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX62343.1 - 0.067 13.1 1.0 0.19 11.6 0.2 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX62343.1 - 0.095 12.0 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-N PF05238.13 ORX62344.1 - 1.7e-22 80.3 0.6 2.4e-22 79.8 0.6 1.2 1 0 0 1 1 1 1 Kinetochore protein CHL4 like Ribosomal_L30_N PF08079.12 ORX62344.1 - 0.027 14.7 0.3 0.044 14.0 0.3 1.3 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain IL1_propep PF02394.16 ORX62344.1 - 0.15 13.0 1.6 0.47 11.4 1.6 1.9 1 0 0 1 1 1 0 Interleukin-1 propeptide NDT80_PhoG PF05224.12 ORX62345.1 - 6.2e-38 130.9 0.0 2.1e-37 129.2 0.0 2.0 1 1 0 1 1 1 1 NDT80 / PhoG like DNA-binding family GAS2 PF02187.17 ORX62346.1 - 1.1e-13 51.0 0.2 4.3e-13 49.1 0.2 2.1 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain DUF2203 PF09969.9 ORX62346.1 - 1.1 10.0 10.2 0.52 11.0 1.0 4.5 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2203) DDHD PF02862.17 ORX62346.1 - 1.2 9.2 10.0 0.83 9.8 0.7 3.3 3 0 0 3 3 3 0 DDHD domain FAM104 PF15434.6 ORX62347.1 - 0.064 13.8 1.5 0.14 12.7 1.5 1.6 1 1 0 1 1 1 0 Family 104 Aldedh PF00171.22 ORX62348.1 - 1.9e-61 208.0 0.0 2.4e-60 204.3 0.0 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Arginase PF00491.21 ORX62349.1 - 2.5e-57 194.5 0.1 3.2e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 Arginase family DUF2117 PF09890.9 ORX62349.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2117) Ribosomal_L24e PF01246.20 ORX62350.1 - 7.1e-31 106.2 0.4 7.1e-31 106.2 0.4 1.8 2 1 1 3 3 3 1 Ribosomal protein L24e SH2_2 PF14633.6 ORX62353.1 - 4.2e-71 238.8 0.1 8.9e-71 237.7 0.1 1.6 1 0 0 1 1 1 1 SH2 domain YqgF PF14639.6 ORX62353.1 - 9.2e-35 119.6 0.0 2e-34 118.6 0.0 1.6 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 ORX62353.1 - 1e-26 93.3 0.0 2.8e-26 91.9 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix motif HTH_44 PF14641.6 ORX62353.1 - 7.8e-24 84.3 0.2 2.2e-23 82.9 0.2 1.7 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 ORX62353.1 - 2e-17 63.6 30.4 2e-17 63.6 30.4 4.8 4 1 0 4 4 4 1 Acidic N-terminal SPT6 SH2 PF00017.24 ORX62353.1 - 2.1e-07 31.0 0.0 2.6e-06 27.4 0.0 2.8 2 0 0 2 2 2 1 SH2 domain HHH_9 PF17674.1 ORX62353.1 - 1.4e-05 25.9 2.0 7.8e-05 23.5 0.1 3.4 3 0 0 3 3 3 1 HHH domain Tex_YqgF PF16921.5 ORX62353.1 - 0.00012 22.5 0.0 0.00031 21.2 0.0 1.7 1 0 0 1 1 1 1 Tex protein YqgF-like domain S1 PF00575.23 ORX62353.1 - 0.00018 21.8 0.0 0.00043 20.6 0.0 1.7 1 0 0 1 1 1 1 S1 RNA binding domain HHH_3 PF12836.7 ORX62353.1 - 0.013 15.7 0.0 0.04 14.2 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif Isochorismatase PF00857.20 ORX62353.1 - 0.06 13.5 0.1 1.2 9.2 0.0 2.8 3 0 0 3 3 3 0 Isochorismatase family TMEM61 PF15105.6 ORX62355.1 - 0.072 12.9 0.3 0.072 12.9 0.3 1.7 1 1 1 2 2 2 0 TMEM61 protein family Nodulin_late PF07127.11 ORX62355.1 - 0.11 12.9 4.4 0.14 12.5 4.4 1.2 1 0 0 1 1 1 0 Late nodulin protein Pex14_N PF04695.13 ORX62355.1 - 0.19 12.4 7.0 0.28 11.8 7.0 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SNARE PF05739.19 ORX62355.1 - 0.82 9.7 4.5 1.3 9.1 4.5 1.2 1 0 0 1 1 1 0 SNARE domain Peptidase_C48 PF02902.19 ORX62357.1 - 1.1e-12 48.3 0.0 2.6e-12 47.1 0.0 1.6 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_M48_N PF16491.5 ORX62358.1 - 7.6e-68 228.0 7.3 7.6e-68 228.0 7.3 2.4 2 1 1 3 3 3 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 ORX62358.1 - 2.9e-46 157.7 0.0 5.2e-46 156.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 ORX62358.1 - 0.0012 18.1 7.5 0.0016 17.7 3.4 2.7 2 1 1 3 3 3 2 BlaR1 peptidase M56 SprT-like PF10263.9 ORX62358.1 - 0.021 14.7 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 SprT-like family DUF2268 PF10026.9 ORX62358.1 - 0.089 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) ABC2_membrane PF01061.24 ORX62358.1 - 0.96 8.8 23.3 2.3 7.6 4.4 2.2 2 0 0 2 2 2 0 ABC-2 type transporter WD40 PF00400.32 ORX62359.1 - 3.1e-12 46.8 2.2 0.00084 20.1 0.0 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Ins_P5_2-kin PF06090.12 ORX62360.1 - 1.4e-69 235.0 0.0 1.6e-69 234.8 0.0 1.0 1 0 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Homeodomain PF00046.29 ORX62361.1 - 1.5e-19 69.6 2.7 2.9e-19 68.6 2.7 1.5 1 0 0 1 1 1 1 Homeodomain Red1 PF07964.11 ORX62361.1 - 0.41 8.8 3.1 0.57 8.4 3.1 1.1 1 0 0 1 1 1 0 Rec10 / Red1 CNH PF00780.22 ORX62362.1 - 2.5e-57 194.6 0.0 5.8e-57 193.4 0.0 1.6 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 ORX62362.1 - 2.2e-36 125.8 0.0 5.6e-36 124.5 0.0 1.7 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 ORX62362.1 - 3.2e-33 114.7 0.0 8.2e-33 113.4 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DEP PF00610.21 ORX62362.1 - 1.2e-11 44.5 0.1 2.5e-11 43.4 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH_13 PF16652.5 ORX62362.1 - 0.00036 20.4 0.0 0.23 11.3 0.1 3.0 2 1 0 2 2 2 2 Pleckstrin homology domain PH PF00169.29 ORX62362.1 - 0.13 12.8 0.0 5.7 7.5 0.0 3.2 2 1 0 2 2 2 0 PH domain Eco57I PF07669.11 ORX62363.1 - 0.00027 21.4 0.0 0.021 15.3 0.0 2.9 3 0 0 3 3 3 1 Eco57I restriction-modification methylase CTP_transf_1 PF01148.20 ORX62364.1 - 1.6e-70 237.9 21.8 2.1e-70 237.5 21.8 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Popeye PF04831.13 ORX62364.1 - 1.9 8.7 8.3 0.26 11.5 3.2 2.2 2 0 0 2 2 2 0 Popeye protein conserved region SPT2 PF08243.11 ORX62365.1 - 6.5e-19 68.5 22.9 6.5e-19 68.5 22.9 2.0 2 0 0 2 2 2 1 SPT2 chromatin protein Ndc1_Nup PF09531.10 ORX62365.1 - 3.5 6.2 7.7 3.6 6.1 7.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Ax_dynein_light PF10211.9 ORX62366.1 - 0.25 11.3 12.5 0.32 10.9 12.5 1.2 1 0 0 1 1 1 0 Axonemal dynein light chain DUF2514 PF10721.9 ORX62366.1 - 3.4 7.7 15.1 4.3 7.4 15.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Allexi_40kDa PF05549.11 ORX62366.1 - 4.4 6.7 7.9 6.2 6.3 7.9 1.3 1 1 0 1 1 1 0 Allexivirus 40kDa protein V_ATPase_I PF01496.19 ORX62366.1 - 8.2 4.2 6.8 8.6 4.1 6.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_Gp23 PF10669.9 ORX62366.1 - 9.5 6.6 11.7 14 6.0 11.6 1.4 1 1 0 1 1 1 0 Protein gp23 (Bacteriophage A118) MFS_1 PF07690.16 ORX62367.1 - 5.8e-32 111.0 27.1 5.8e-32 111.0 27.1 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 ORX62367.1 - 9.3e-05 21.9 5.1 9.3e-05 21.9 5.1 1.9 2 1 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Caveolin PF01146.17 ORX62367.1 - 0.34 10.9 5.2 0.28 11.1 0.6 2.4 2 0 0 2 2 2 0 Caveolin Fasciclin PF02469.22 ORX62368.1 - 8.6e-46 155.3 0.2 1.1e-18 67.7 0.0 3.2 3 0 0 3 3 3 3 Fasciclin domain DUF4381 PF14316.6 ORX62368.1 - 0.071 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) PLDc_N PF13396.6 ORX62368.1 - 0.075 13.0 0.9 0.12 12.3 0.9 1.3 1 0 0 1 1 1 0 Phospholipase_D-nuclease N-terminal RIFIN PF02009.16 ORX62369.1 - 0.97 9.3 2.1 1.9 8.3 2.1 1.4 1 0 0 1 1 1 0 Rifin DUF63 PF01889.17 ORX62369.1 - 1.4 9.1 11.9 1.3 9.1 0.1 2.1 2 0 0 2 2 2 0 Membrane protein of unknown function DUF63 NDUF_B8 PF05821.11 ORX62370.1 - 9e-11 41.9 0.1 1.3e-10 41.4 0.1 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Gln-synt_C PF00120.24 ORX62370.1 - 0.24 10.4 0.0 0.3 10.1 0.0 1.1 1 0 0 1 1 1 0 Glutamine synthetase, catalytic domain Gpr1_Fun34_YaaH PF01184.19 ORX62371.1 - 1.1e-69 234.2 21.5 1.2e-69 234.0 21.5 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family MAP17 PF15807.5 ORX62371.1 - 0.19 12.0 0.5 0.33 11.2 0.5 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TPR_11 PF13414.6 ORX62372.1 - 3.2e-12 45.9 1.9 0.013 15.2 0.0 5.2 5 0 0 5 5 5 3 TPR repeat TPR_17 PF13431.6 ORX62372.1 - 4.9e-05 23.4 0.1 0.088 13.2 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62372.1 - 0.00016 21.6 1.0 63 4.2 0.0 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX62372.1 - 0.0017 18.1 8.0 16 5.5 0.2 7.1 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62372.1 - 0.0035 17.4 13.2 19 5.7 0.2 8.0 9 1 0 9 9 9 0 Tetratricopeptide repeat ARA70 PF12489.8 ORX62372.1 - 0.0098 16.1 0.1 0.032 14.4 0.0 2.0 1 1 0 1 1 1 1 Nuclear coactivator TPR_12 PF13424.6 ORX62372.1 - 0.016 15.5 4.8 38 4.7 0.1 5.4 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62372.1 - 0.017 15.9 9.6 7.2 7.7 0.0 6.4 6 1 1 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62372.1 - 0.063 13.8 11.9 26 5.4 0.0 6.8 7 2 1 8 8 8 0 Tetratricopeptide repeat MIT PF04212.18 ORX62372.1 - 0.091 12.8 5.3 58 3.9 0.0 5.2 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain ATP-synt_DE PF00401.20 ORX62372.1 - 0.13 12.5 3.3 16 5.9 0.2 3.6 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain TPR_7 PF13176.6 ORX62372.1 - 0.14 12.3 7.4 2 8.6 0.1 5.7 7 0 0 7 7 7 0 Tetratricopeptide repeat Zip PF02535.22 ORX62373.1 - 3.5e-57 194.1 12.7 5.4e-57 193.5 12.7 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter ArsC PF03960.15 ORX62374.1 - 0.00012 22.1 0.0 0.00018 21.4 0.0 1.6 1 1 0 1 1 1 1 ArsC family DUF1687 PF07955.11 ORX62374.1 - 0.00028 21.3 0.1 0.0017 18.8 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1687) Pilin_PilA PF14245.6 ORX62374.1 - 0.18 11.8 0.0 0.25 11.3 0.0 1.2 1 0 0 1 1 1 0 Type IV pilin PilA Ribosomal_L36 PF00444.18 ORX62375.1 - 0.076 13.2 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L36 MRP-L20 PF12824.7 ORX62376.1 - 1.4e-22 80.6 2.6 1.7e-22 80.3 2.6 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 ORX62376.1 - 8e-06 26.0 0.0 1.3e-05 25.3 0.0 1.5 2 0 0 2 2 2 1 Neugrin HTH_32 PF13565.6 ORX62376.1 - 0.00081 20.0 0.2 0.0018 18.8 0.2 1.7 1 0 0 1 1 1 1 Homeodomain-like domain Xrn1_D3 PF18194.1 ORX62376.1 - 0.088 12.9 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Exoribonuclease 1 Domain-3 Ku PF02735.16 ORX62377.1 - 9.8e-28 97.3 0.0 2.2e-27 96.1 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ORX62377.1 - 1.6e-12 47.7 0.1 2.7e-12 46.9 0.1 1.4 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 ORX62377.1 - 2.1e-05 25.1 0.2 6.4e-05 23.6 0.2 1.9 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm HMG_box PF00505.19 ORX62378.1 - 2e-17 63.3 2.8 3.4e-17 62.6 2.8 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX62378.1 - 1.8e-07 31.7 1.3 3.2e-07 30.8 1.3 1.3 1 0 0 1 1 1 1 HMG-box domain COX4 PF02936.14 ORX62378.1 - 0.013 15.6 0.5 0.027 14.5 0.5 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV HEM4 PF02602.15 ORX62379.1 - 1e-39 136.3 0.0 1.2e-39 136.1 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD DUF1612 PF07756.12 ORX62379.1 - 0.016 15.4 0.7 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1612) Thaumatin PF00314.17 ORX62380.1 - 7.5e-49 166.3 18.4 1.7e-48 165.1 18.4 1.5 1 1 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 ORX62380.1 - 0.0039 16.5 2.8 0.25 10.6 0.0 2.6 1 1 1 2 2 2 2 Beta-1,3-glucanase Gpr1_Fun34_YaaH PF01184.19 ORX62381.1 - 7.6e-19 68.1 18.5 9e-19 67.9 18.5 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family PhyH PF05721.13 ORX62382.1 - 1.1e-51 176.1 0.0 1.3e-51 175.9 0.0 1.0 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 ORX62382.1 - 0.048 14.1 0.0 0.087 13.2 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase RhoGEF PF00621.20 ORX62383.1 - 5.3e-13 49.6 0.0 7.8e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain Mito_carr PF00153.27 ORX62384.1 - 3.8e-61 203.0 4.1 6.5e-21 74.1 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein WD40 PF00400.32 ORX62385.1 - 1.1e-13 51.4 17.5 1.1e-05 26.1 0.1 6.9 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62385.1 - 0.034 14.4 0.2 3.1 8.2 0.1 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain ComFB PF10719.9 ORX62385.1 - 0.28 11.3 0.6 0.92 9.6 0.1 2.2 2 0 0 2 2 2 0 Late competence development protein ComFB Keratin_2_head PF16208.5 ORX62386.1 - 0.13 12.4 4.0 0.16 12.1 4.0 1.1 1 0 0 1 1 1 0 Keratin type II head zinc_ribbon_10 PF10058.9 ORX62387.1 - 2.8e-18 65.4 0.3 4.5e-18 64.7 0.3 1.3 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF3810 PF12725.7 ORX62387.1 - 0.0035 16.7 0.2 0.0066 15.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3810) NMD3 PF04981.13 ORX62387.1 - 3.4 7.1 5.7 0.75 9.2 0.1 2.1 2 0 0 2 2 2 0 NMD3 family Thioredoxin_4 PF13462.6 ORX62387.1 - 7.7 6.6 6.8 5.4 7.1 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin FHA PF00498.26 ORX62388.1 - 6.9e-18 64.8 0.1 1.1e-17 64.1 0.1 1.4 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 ORX62388.1 - 1.5e-12 47.0 5.5 1.5e-12 47.0 5.5 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_2 PF13639.6 ORX62388.1 - 4.1e-09 36.6 7.6 4.1e-09 36.6 7.6 1.9 2 0 0 2 2 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 ORX62388.1 - 3.4e-06 27.3 0.0 5.6e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_3 PF13920.6 ORX62388.1 - 1.2e-05 25.1 4.8 2.6e-05 24.0 4.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ORX62388.1 - 9.8e-05 22.1 6.8 0.00019 21.2 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX62388.1 - 0.00015 21.5 8.7 0.00034 20.4 8.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ORX62388.1 - 0.00017 21.4 6.7 0.00017 21.4 6.7 1.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ORX62388.1 - 0.00024 20.9 5.4 0.00055 19.7 5.4 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 PHD PF00628.29 ORX62388.1 - 0.0027 17.5 4.1 0.0056 16.5 4.1 1.6 1 0 0 1 1 1 1 PHD-finger zf-rbx1 PF12678.7 ORX62388.1 - 0.011 16.0 7.0 0.038 14.3 7.0 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ORX62388.1 - 0.031 14.3 10.5 0.069 13.2 10.5 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 ORX62388.1 - 0.039 14.0 2.0 0.039 14.0 2.0 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ORX62388.1 - 2.2 8.0 8.9 0.51 10.0 4.6 2.2 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type Prok-RING_1 PF14446.6 ORX62388.1 - 3.9 7.5 6.8 14 5.7 0.7 3.4 4 0 0 4 4 4 0 Prokaryotic RING finger family 1 Ribosomal_L32e PF01655.18 ORX62389.1 - 2.4e-52 175.9 0.7 2.9e-52 175.6 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Spectrin_like PF18373.1 ORX62390.1 - 0.038 14.1 0.2 0.074 13.1 0.2 1.5 1 0 0 1 1 1 0 Spectrin like domain C2 PF00168.30 ORX62391.1 - 8e-08 32.5 0.0 1.5e-07 31.6 0.0 1.5 1 0 0 1 1 1 1 C2 domain C2-C2_1 PF11618.8 ORX62391.1 - 1.5e-06 28.3 0.0 2.7e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 First C2 domain of RPGR-interacting protein 1 UBA PF00627.31 ORX62391.1 - 2.6e-06 27.2 0.5 6.8e-06 25.9 0.5 1.8 1 0 0 1 1 1 1 UBA/TS-N domain MRPL52 PF18699.1 ORX62391.1 - 0.013 15.6 3.0 0.93 9.7 0.8 3.1 2 0 0 2 2 2 0 Mitoribosomal protein mL52 APG12 PF04110.13 ORX62392.1 - 5.9e-33 113.1 0.0 8.5e-33 112.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 ORX62392.1 - 0.014 15.6 0.0 0.016 15.4 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Atg8 ubiquitin like LSM PF01423.22 ORX62393.1 - 2.3e-20 72.0 0.2 2.9e-20 71.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain FoP_duplication PF13865.6 ORX62393.1 - 0.011 16.2 8.0 0.016 15.8 8.0 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 PhosphMutase PF10143.9 ORX62394.1 - 8.6e-50 168.9 0.0 1.4e-49 168.3 0.0 1.3 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 ORX62394.1 - 1.1e-28 100.3 0.0 1.4e-28 100.0 0.0 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.22 ORX62394.1 - 8.8e-08 32.1 0.0 4.3e-06 26.6 0.0 2.2 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ORX62394.1 - 0.013 15.0 0.0 0.038 13.4 0.0 1.7 2 0 0 2 2 2 0 Sulfatase Alk_phosphatase PF00245.20 ORX62394.1 - 0.056 12.4 0.0 0.081 11.9 0.0 1.2 1 0 0 1 1 1 0 Alkaline phosphatase HMG_box PF00505.19 ORX62395.1 - 5e-20 71.7 0.7 9.6e-20 70.8 0.7 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ORX62395.1 - 3.3e-07 30.8 0.1 6.4e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 HMG-box domain RRM_1 PF00076.22 ORX62396.1 - 4.6e-05 23.1 0.0 0.0001 22.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WW PF00397.26 ORX62397.1 - 0.00039 20.4 11.2 0.00039 20.4 11.2 2.3 2 0 0 2 2 2 1 WW domain Rootletin PF15035.6 ORX62398.1 - 0.15 12.0 0.2 0.15 12.0 0.2 2.1 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion SLAC1 PF03595.17 ORX62399.1 - 1.1e-68 231.9 47.5 4.6e-55 187.1 32.2 2.0 1 1 1 2 2 2 2 Voltage-dependent anion channel Ceramidase_alk PF04734.13 ORX62400.1 - 3.1e-190 633.1 0.9 3.7e-190 632.9 0.9 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 ORX62400.1 - 3e-43 147.6 0.1 4.9e-43 146.9 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Ctr PF04145.15 ORX62401.1 - 5.9e-09 36.7 10.5 1e-07 32.7 3.4 2.1 1 1 1 2 2 2 2 Ctr copper transporter family 7tm_1 PF00001.21 ORX62401.1 - 2 7.7 6.0 1.3 8.3 0.7 2.0 1 1 1 2 2 2 0 7 transmembrane receptor (rhodopsin family) GPI-anchored PF10342.9 ORX62402.1 - 3.4e-10 40.5 1.2 3.5e-10 40.5 0.2 1.5 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family GPI-anchored PF10342.9 ORX62403.1 - 3.4e-10 40.5 1.2 3.5e-10 40.5 0.2 1.5 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family GPI-anchored PF10342.9 ORX62404.1 - 3.4e-11 43.7 1.8 3.4e-11 43.7 1.8 1.6 1 1 1 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family ABC1 PF03109.16 ORX62405.1 - 1.5e-19 70.3 0.0 4.9e-11 42.8 0.0 2.6 2 0 0 2 2 2 2 ABC1 family RhoGAP PF00620.27 ORX62406.1 - 3.8e-41 140.4 0.0 7.3e-41 139.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain DUF3261 PF11659.8 ORX62407.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3261) Mito_carr PF00153.27 ORX62409.1 - 1.1e-19 70.1 0.2 3.4e-15 55.7 0.0 3.2 3 0 0 3 3 3 2 Mitochondrial carrier protein Bmt2 PF11968.8 ORX62410.1 - 4.2e-72 242.6 0.0 5.5e-72 242.2 0.0 1.1 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Epimerase PF01370.21 ORX62412.1 - 1.1e-53 182.2 0.0 2.8e-53 180.9 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ORX62412.1 - 5.9e-15 55.5 0.0 1.5e-14 54.2 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ORX62412.1 - 8.6e-06 25.1 0.1 0.00093 18.4 0.0 2.9 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ORX62412.1 - 0.006 15.7 0.0 0.017 14.3 0.0 1.6 2 0 0 2 2 2 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ORX62412.1 - 0.0094 15.0 0.1 0.022 13.8 0.1 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family zf-C2H2 PF00096.26 ORX62413.1 - 8.3e-09 35.4 9.4 5.5e-05 23.4 2.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX62413.1 - 1.1e-06 28.8 1.3 1.1e-06 28.8 1.3 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_8 PF15909.5 ORX62413.1 - 0.00027 21.2 0.7 0.00067 19.9 0.6 1.7 1 1 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ORX62413.1 - 0.01 16.6 11.8 0.11 13.4 1.4 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger FOXP-CC PF16159.5 ORX62413.1 - 0.019 15.6 0.8 0.8 10.4 0.1 2.4 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 ORX62413.1 - 0.16 12.1 1.2 0.57 10.3 0.8 1.8 1 1 1 2 2 2 0 Aberrant zinc-finger zf-C2H2_6 PF13912.6 ORX62413.1 - 0.34 11.0 0.1 0.34 11.0 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger PRIMA1 PF16101.5 ORX62413.1 - 2.8 8.0 5.9 6.1 6.9 4.9 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 E2F_TDP PF02319.20 ORX62414.1 - 2.7e-25 88.2 0.8 4.2e-25 87.6 0.8 1.3 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain TrmB PF01978.19 ORX62414.1 - 0.025 14.5 0.1 0.073 13.0 0.0 1.7 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 ORX62414.1 - 0.033 14.3 0.6 0.052 13.7 0.2 1.6 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC UPF0122 PF04297.14 ORX62414.1 - 0.034 14.4 0.2 0.034 14.4 0.2 1.7 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like REV1_C PF16727.5 ORX62414.1 - 0.037 14.4 0.0 0.084 13.3 0.0 1.5 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain DUF489 PF04356.12 ORX62414.1 - 0.04 13.9 0.4 0.11 12.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Sigma70_r4 PF04545.16 ORX62414.1 - 0.047 13.2 0.2 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_25 PF13413.6 ORX62414.1 - 0.13 12.1 0.3 0.24 11.3 0.3 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain COMMD1_N PF17221.3 ORX62414.1 - 0.14 12.4 1.6 0.8 10.0 0.1 2.3 2 1 0 2 2 2 0 COMMD1 N-terminal domain DUF4795 PF16043.5 ORX62414.1 - 0.17 11.4 2.8 1.2 8.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) DUF1003 PF06210.11 ORX62414.1 - 1.7 8.8 5.4 0.59 10.3 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) SNCAIP_SNCA_bd PF16700.5 ORX62414.1 - 9.8 6.0 7.4 1.9 8.3 0.1 3.0 2 1 1 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain SKA2 PF16740.5 ORX62415.1 - 0.00022 21.0 1.1 0.00038 20.2 1.1 1.4 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 Sec34 PF04136.15 ORX62415.1 - 0.016 15.1 0.4 0.032 14.1 0.4 1.4 1 0 0 1 1 1 0 Sec34-like family 2_5_RNA_ligase2 PF13563.6 ORX62415.1 - 0.044 13.7 0.6 0.25 11.2 0.1 2.1 2 0 0 2 2 2 0 2'-5' RNA ligase superfamily UPF0449 PF15136.6 ORX62415.1 - 4.6 7.8 7.1 20 5.7 5.2 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 ADH_zinc_N PF00107.26 ORX62416.1 - 1.8e-27 95.8 0.1 3.7e-27 94.9 0.1 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ORX62416.1 - 4.9e-15 56.8 0.0 1.1e-14 55.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX62416.1 - 1e-09 38.2 2.3 4.7e-09 36.1 0.0 2.8 2 1 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain TrkA_N PF02254.18 ORX62416.1 - 0.083 13.2 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain WD40 PF00400.32 ORX62417.1 - 1.9e-09 38.0 0.4 0.01 16.7 0.3 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62417.1 - 0.00051 20.3 0.1 1.1 9.6 0.0 3.8 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Flavi_propep PF01570.17 ORX62419.1 - 0.018 15.0 0.2 0.026 14.5 0.2 1.2 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide PsaM PF07465.13 ORX62419.1 - 0.24 11.1 1.9 0.44 10.3 1.9 1.4 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) DUF3648 PF12364.8 ORX62420.1 - 0.024 14.9 0.0 0.045 14.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3648) Mg_trans_NIPA PF05653.14 ORX62422.1 - 1.9e-55 188.1 16.9 1e-53 182.4 13.6 2.0 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 ORX62422.1 - 0.00012 22.3 2.1 0.00012 22.3 2.1 4.0 3 2 1 4 4 4 2 EamA-like transporter family TssN PF17555.2 ORX62422.1 - 4.8 6.5 9.0 10 5.4 9.0 1.6 1 1 0 1 1 1 0 Type VI secretion system, TssN LMBR1 PF04791.16 ORX62423.1 - 0.065 12.1 2.7 0.1 11.5 2.7 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein MRP-L46 PF11788.8 ORX62423.1 - 0.74 10.6 8.8 0.32 11.8 3.5 2.6 2 1 1 3 3 3 0 39S mitochondrial ribosomal protein L46 MPTase-PolyVal PF18818.1 ORX62424.1 - 1.1e-05 25.5 0.1 2.7e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Metallopeptidase superfamily domain Peptidase_M49 PF03571.15 ORX62424.1 - 0.00041 18.8 0.0 0.0035 15.8 0.0 2.3 3 0 0 3 3 3 1 Peptidase family M49 FKBP_C PF00254.28 ORX62425.1 - 1.1e-32 112.2 0.0 1.5e-32 111.8 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Fungus-induced PF10917.8 ORX62425.1 - 0.063 13.6 0.3 0.15 12.4 0.0 1.8 2 0 0 2 2 2 0 Fungus-induced protein AhpC-TSA PF00578.21 ORX62426.1 - 1.5e-30 105.6 0.0 2e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ORX62426.1 - 3.9e-12 46.1 0.0 5e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ORX62426.1 - 9.5e-10 38.2 0.0 1.6e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Methyltransf_25 PF13649.6 ORX62427.1 - 7.6e-06 26.5 0.0 2.4e-05 25.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX62427.1 - 0.00011 22.1 0.0 0.001 18.9 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX62427.1 - 0.00038 20.3 0.0 0.0013 18.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Rhodanese PF00581.20 ORX62427.1 - 0.00072 20.1 0.0 0.0012 19.4 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Methyltransf_12 PF08242.12 ORX62427.1 - 0.0011 19.6 0.0 0.0021 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 ORX62427.1 - 0.12 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Methyltransf_11 PF08241.12 ORX62427.1 - 0.14 12.8 0.1 0.33 11.6 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 ORX62427.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_4 PF02390.17 ORX62427.1 - 0.21 11.0 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase E1-E2_ATPase PF00122.20 ORX62428.1 - 3.3e-51 173.4 0.3 5.6e-50 169.4 0.1 2.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX62428.1 - 2.2e-15 57.5 0.0 5.2e-15 56.3 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX62428.1 - 9.4e-14 50.9 0.0 2.2e-13 49.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ORX62428.1 - 1.6e-05 24.8 0.3 3.2e-05 23.8 0.3 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SUIM_assoc PF16619.5 ORX62428.1 - 0.066 13.3 0.1 0.2 11.7 0.1 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Cation_ATPase PF13246.6 ORX62428.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 ORX62428.1 - 2.8 7.6 9.4 8.7 6.0 9.4 1.8 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus RasGEF_N PF00618.20 ORX62430.1 - 7.8e-08 32.5 0.1 1.4e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 RasGEF N-terminal motif GATA PF00320.27 ORX62431.1 - 2.8e-15 55.6 3.0 2.8e-15 55.6 3.0 2.7 2 1 0 2 2 2 1 GATA zinc finger ArfGap PF01412.18 ORX62431.1 - 0.0027 17.8 1.6 0.44 10.6 0.2 2.4 2 0 0 2 2 2 2 Putative GTPase activating protein for Arf zinc_ribbon_10 PF10058.9 ORX62431.1 - 0.086 12.6 0.3 0.086 12.6 0.3 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein TF_Zn_Ribbon PF08271.12 ORX62431.1 - 0.11 12.1 0.5 0.27 10.8 0.5 1.7 1 0 0 1 1 1 0 TFIIB zinc-binding eIF-5_eIF-2B PF01873.17 ORX62431.1 - 1.1 9.2 5.3 3.4 7.6 0.3 2.3 2 0 0 2 2 2 0 Domain found in IF2B/IF5 DZR PF12773.7 ORX62431.1 - 5.2 7.2 7.7 16 5.6 0.8 2.7 2 1 1 3 3 3 0 Double zinc ribbon AAA PF00004.29 ORX62432.1 - 2.2e-42 144.6 0.0 5.3e-42 143.4 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ORX62432.1 - 5.3e-29 100.0 0.2 2.6e-28 97.8 0.1 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ORX62432.1 - 5.6e-20 71.2 6.0 1.2e-19 70.1 6.0 1.6 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 ORX62432.1 - 4.6e-06 27.1 0.3 0.0001 22.7 0.1 2.7 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ORX62432.1 - 4.9e-05 23.1 0.0 9.7e-05 22.2 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ORX62432.1 - 6.3e-05 22.8 0.0 0.00012 21.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 ORX62432.1 - 0.0001 22.6 1.0 0.026 14.8 0.0 2.9 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 ORX62432.1 - 0.00013 21.9 0.0 0.00065 19.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 ORX62432.1 - 0.00015 21.5 0.0 0.0007 19.4 0.0 2.2 2 0 0 2 2 1 1 AAA+ lid domain TIP49 PF06068.13 ORX62432.1 - 0.00018 20.8 0.1 0.0006 19.1 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain DUF815 PF05673.13 ORX62432.1 - 0.0002 20.6 0.0 0.0041 16.3 0.0 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 ORX62432.1 - 0.00027 21.0 0.2 0.0017 18.4 0.0 2.3 3 0 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 ORX62432.1 - 0.00082 19.7 0.1 0.015 15.7 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 ORX62432.1 - 0.0015 18.7 0.0 0.0043 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ORX62432.1 - 0.0022 18.5 0.0 0.0059 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ORX62432.1 - 0.0023 18.1 0.1 0.0084 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ORX62432.1 - 0.0057 16.4 0.0 0.013 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ORX62432.1 - 0.0083 15.7 0.7 0.54 9.8 0.1 2.5 2 1 1 3 3 3 1 AAA domain Bac_DnaA PF00308.18 ORX62432.1 - 0.021 14.7 0.4 2.2 8.1 0.0 2.7 2 1 0 2 2 2 0 Bacterial dnaA protein AAA_17 PF13207.6 ORX62432.1 - 0.023 15.1 0.4 0.089 13.2 0.0 2.2 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ORX62432.1 - 0.034 13.5 0.0 0.093 12.1 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 ORX62432.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.5 1 0 0 1 1 1 0 Torsin Parvo_NS1 PF01057.17 ORX62432.1 - 0.055 12.5 0.3 0.13 11.4 0.0 1.7 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PhoH PF02562.16 ORX62432.1 - 0.074 12.5 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.12 ORX62432.1 - 0.086 12.8 0.0 0.8 9.6 0.0 2.2 1 1 1 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ORX62432.1 - 0.088 12.7 0.6 2.4 8.0 0.0 2.6 2 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 ORX62432.1 - 0.095 12.2 0.0 0.28 10.7 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ORX62432.1 - 0.14 11.8 0.0 0.39 10.4 0.0 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 ORX62432.1 - 0.14 11.8 2.8 0.35 10.6 0.1 2.2 2 0 0 2 2 2 0 Cytidylate kinase ATPase PF06745.13 ORX62432.1 - 0.26 10.6 0.6 12 5.2 0.0 2.7 2 1 1 3 3 3 0 KaiC Methyltransf_32 PF13679.6 ORX62432.1 - 0.29 11.1 0.7 20 5.2 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain AAA_11 PF13086.6 ORX62432.1 - 0.31 10.8 1.7 7.7 6.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain THOC2_N PF16134.5 ORX62432.1 - 3.8 6.0 6.7 5.4 5.5 6.7 1.2 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus EF-hand_1 PF00036.32 ORX62434.1 - 1.7e-29 99.1 6.4 7e-08 31.5 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX62434.1 - 1.3e-26 92.8 10.8 6.5e-15 55.3 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX62434.1 - 6.9e-23 78.6 6.1 1.2e-07 31.1 0.1 4.5 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ORX62434.1 - 5.6e-18 64.5 15.4 4.8e-08 32.7 0.6 4.2 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ORX62434.1 - 1.9e-15 55.5 10.4 3.5e-06 26.3 0.2 4.8 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 ORX62434.1 - 2.7e-11 43.6 1.3 1.7e-05 25.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX62434.1 - 2.8e-09 36.9 2.0 0.0009 19.2 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX62434.1 - 1e-05 25.8 4.5 0.003 17.9 0.2 2.3 1 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region OST-HTH PF12872.7 ORX62434.1 - 0.00093 19.0 0.0 1.9 8.4 0.0 3.8 2 1 2 4 4 4 1 OST-HTH/LOTUS domain EF-hand_14 PF17959.1 ORX62434.1 - 0.011 16.1 0.2 0.13 12.6 0.1 2.4 2 1 0 2 2 2 0 EF-hand domain TerB PF05099.13 ORX62434.1 - 0.016 15.2 0.2 0.12 12.4 0.0 2.1 2 1 1 3 3 3 0 Tellurite resistance protein TerB Caleosin PF05042.13 ORX62434.1 - 0.039 13.9 5.5 3.3 7.6 0.0 3.5 1 1 3 4 4 4 0 Caleosin related protein DUF2383 PF09537.10 ORX62434.1 - 0.16 12.3 0.7 4.4 7.7 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2383) Pkinase PF00069.25 ORX62436.1 - 4.1e-71 239.4 0.0 4.9e-71 239.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62436.1 - 8.8e-37 126.8 0.0 1.4e-36 126.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX62436.1 - 4.7e-08 32.4 0.1 1.2e-07 31.0 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX62436.1 - 0.0031 16.9 0.0 0.0054 16.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ORX62436.1 - 0.0064 16.4 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX62436.1 - 0.067 12.5 0.1 0.38 10.1 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CLPTM1 PF05602.12 ORX62437.1 - 4.8e-57 193.9 0.1 6.4e-55 186.9 0.1 2.1 1 1 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) RasGEF PF00617.19 ORX62439.1 - 1e-48 165.9 0.0 3.1e-48 164.3 0.0 1.9 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX62439.1 - 2e-16 60.1 2.5 6.6e-16 58.5 2.5 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif Ring_hydroxyl_B PF00866.18 ORX62439.1 - 0.016 15.3 0.3 0.04 14.0 0.3 1.6 1 0 0 1 1 1 0 Ring hydroxylating beta subunit UTP15_C PF09384.10 ORX62440.1 - 5.3e-46 156.0 1.0 9.2e-46 155.2 0.7 1.6 2 0 0 2 2 2 1 UTP15 C terminal WD40 PF00400.32 ORX62440.1 - 4.2e-26 90.7 5.0 1.7e-05 25.4 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62440.1 - 7.5e-12 45.4 0.4 0.007 16.6 0.0 5.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ORX62440.1 - 0.00016 21.6 0.1 0.12 12.4 0.0 3.4 2 1 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ORX62440.1 - 0.00021 20.1 1.7 0.33 9.5 0.0 3.2 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX62440.1 - 0.058 12.7 0.1 0.37 10.1 0.0 2.1 2 1 0 2 2 2 0 WD40-like domain Chorion_S16 PF05836.12 ORX62440.1 - 0.08 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Chorion protein S16 ubiquitin PF00240.23 ORX62442.1 - 1.7e-49 165.4 7.6 4.7e-33 112.8 0.7 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ORX62442.1 - 3.1e-23 81.4 7.5 3.1e-15 55.7 0.6 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like zf-AN1 PF01428.16 ORX62442.1 - 1.8e-10 40.8 10.0 3.3e-10 40.0 10.0 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Ubiquitin_2 PF14560.6 ORX62442.1 - 4.3e-08 33.5 2.3 0.00066 20.1 0.1 2.8 2 1 0 2 2 2 2 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ORX62442.1 - 0.00028 20.9 4.5 2.4 8.3 0.0 4.0 3 1 1 4 4 4 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX62442.1 - 0.0038 17.3 0.1 0.14 12.3 0.0 2.6 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Sde2_N_Ubi PF13019.6 ORX62442.1 - 0.0052 16.6 0.2 0.57 10.0 0.0 2.2 1 1 1 2 2 2 1 Silencing defective 2 N-terminal ubiquitin domain Ubiquitin_5 PF18037.1 ORX62442.1 - 0.011 16.1 0.1 0.026 14.9 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 ORX62442.1 - 0.034 14.7 0.2 0.13 12.8 0.2 2.0 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ORX62442.1 - 0.041 13.8 4.1 0.1 12.5 0.1 2.3 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain Coilin_N PF15862.5 ORX62442.1 - 0.066 13.0 0.2 0.33 10.8 0.1 2.0 2 0 0 2 2 2 0 Coilin N-terminus Ribosomal_L27A PF00828.19 ORX62443.1 - 3.8e-21 76.1 0.2 5.3e-21 75.6 0.1 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A EF1G PF00647.19 ORX62444.1 - 1e-46 157.4 0.6 1e-46 157.4 0.6 2.1 3 0 0 3 3 3 1 Elongation factor 1 gamma, conserved domain GST_N PF02798.20 ORX62444.1 - 1.1e-11 44.8 0.4 3.4e-11 43.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ORX62444.1 - 3.4e-11 43.2 0.1 3.4e-11 43.2 0.1 2.4 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ORX62444.1 - 8.4e-08 32.1 0.0 1.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX62444.1 - 2.2e-05 24.6 0.1 2.2e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX62444.1 - 8.8e-05 22.8 0.0 0.00024 21.5 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Ank_2 PF12796.7 ORX62445.1 - 6.8e-11 42.6 0.0 1.1e-10 42.0 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ORX62445.1 - 3.7e-09 36.6 0.1 3.9e-06 27.0 0.0 3.3 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 ORX62445.1 - 2.3e-08 34.4 0.1 0.00036 21.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ORX62445.1 - 4.9e-07 29.9 0.0 8.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ORX62445.1 - 0.00013 22.1 0.0 0.0014 19.0 0.0 2.6 3 0 0 3 3 3 1 Ankyrin repeat DUF4791 PF16039.5 ORX62445.1 - 0.19 11.2 0.0 0.27 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4791) Glyco_transf_20 PF00982.21 ORX62446.1 - 1.2e-148 495.8 0.0 1.5e-148 495.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX62446.1 - 9.4e-49 165.6 0.0 1.6e-48 164.9 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase CDP-OH_P_transf PF01066.21 ORX62447.1 - 6.5e-19 68.5 0.2 6.5e-19 68.5 0.2 3.8 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase zf-C2H2 PF00096.26 ORX62448.1 - 6e-13 48.5 12.4 3.4e-06 27.2 1.3 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX62448.1 - 2.7e-09 37.1 10.1 7.9e-05 23.2 0.9 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX62448.1 - 2.6e-07 30.8 13.7 4.3e-06 26.9 2.4 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ORX62448.1 - 1.8e-05 24.9 3.9 0.006 16.8 0.8 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX62448.1 - 1.9e-05 25.2 2.1 0.044 14.4 0.2 2.0 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 ORX62448.1 - 0.00038 20.4 10.5 0.00062 19.7 0.2 2.7 2 1 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 ORX62448.1 - 0.0009 19.6 7.2 0.12 12.8 1.6 2.3 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_aberr PF17017.5 ORX62448.1 - 0.00098 19.3 1.3 0.92 9.6 0.1 2.0 2 0 0 2 2 2 2 Aberrant zinc-finger zf-H2C2_5 PF13909.6 ORX62448.1 - 0.0012 18.6 9.7 0.084 12.7 0.3 2.5 2 0 0 2 2 2 2 C2H2-type zinc-finger domain TRAF6_Z2 PF18048.1 ORX62448.1 - 0.0016 18.5 0.5 0.0016 18.5 0.5 2.6 2 1 0 2 2 2 1 TNF receptor-associated factor 6 zinc finger 2 zf-C2H2_2 PF12756.7 ORX62448.1 - 0.0021 18.4 5.0 0.22 11.9 0.2 2.0 1 1 1 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 ORX62448.1 - 0.0055 16.5 1.1 1.7 8.5 0.1 2.0 2 0 0 2 2 2 2 C2H2 type zinc-finger (1 copy) zf-C2H2_8 PF15909.5 ORX62448.1 - 0.016 15.5 2.7 0.27 11.6 1.9 1.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-LYAR PF08790.11 ORX62448.1 - 0.02 14.8 1.7 0.8 9.7 0.2 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-BED PF02892.15 ORX62448.1 - 0.19 11.8 5.3 0.34 11.0 0.4 2.2 2 0 0 2 2 2 0 BED zinc finger zf_ZIC PF18366.1 ORX62448.1 - 0.28 11.3 3.2 6.3 7.0 0.1 2.2 2 0 0 2 2 2 0 Zic proteins zinc finger domain Ribosomal_L31e PF01198.19 ORX62450.1 - 3.9e-37 126.3 1.9 4.9e-37 126.0 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e NARG2_C PF10505.9 ORX62452.1 - 5.6e-12 45.6 0.0 7.1e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 NMDA receptor-regulated gene protein 2 C-terminus CPSase_L_D2 PF02786.17 ORX62453.1 - 5.1e-63 212.4 0.1 8.7e-63 211.6 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 ORX62453.1 - 1.3e-33 115.9 0.1 3.4e-33 114.5 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 ORX62453.1 - 1.4e-27 95.9 0.0 3.7e-27 94.6 0.0 1.8 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp PF02222.22 ORX62453.1 - 1.2e-11 44.5 0.0 2.6e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl PF00364.22 ORX62453.1 - 1.6e-11 43.8 0.5 1.4e-10 40.8 0.2 2.6 3 0 0 3 3 3 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 ORX62453.1 - 2.1e-10 40.5 0.0 3.8e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 ORX62453.1 - 1.1e-08 35.3 0.0 2e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain HlyD_3 PF13437.6 ORX62453.1 - 1.1e-06 29.3 1.0 0.014 16.1 0.1 4.3 4 0 0 4 4 4 2 HlyD family secretion protein HlyD_D23 PF16576.5 ORX62453.1 - 2.4e-05 23.7 0.0 0.00062 19.0 0.0 2.7 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion Biotin_lipoyl_2 PF13533.6 ORX62453.1 - 6.4e-05 22.7 0.3 0.00033 20.4 0.2 2.3 1 1 1 2 2 2 1 Biotin-lipoyl like ATPgrasp_Ter PF15632.6 ORX62453.1 - 0.0015 18.3 0.0 0.0037 17.0 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATPgrasp_ST PF14397.6 ORX62453.1 - 0.0022 17.3 0.1 0.0072 15.6 0.0 1.9 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp RimK PF08443.11 ORX62453.1 - 0.0044 16.6 0.5 0.015 14.9 0.0 2.1 2 1 0 2 2 2 1 RimK-like ATP-grasp domain ATPgrasp_YheCD PF14398.6 ORX62453.1 - 0.0049 16.2 0.0 0.047 12.9 0.0 2.2 2 0 0 2 2 2 1 YheC/D like ATP-grasp NQRA PF05896.11 ORX62453.1 - 0.0099 15.3 0.0 0.023 14.1 0.0 1.6 1 0 0 1 1 1 1 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) RnfC_N PF13375.6 ORX62453.1 - 0.031 14.2 6.4 0.057 13.4 0.1 3.3 4 0 0 4 4 4 0 RnfC Barrel sandwich hybrid domain GSH-S_ATP PF02955.16 ORX62453.1 - 0.039 13.3 0.0 0.097 12.1 0.0 1.6 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, ATP-grasp domain CoA_binding_2 PF13380.6 ORX62453.1 - 0.092 13.2 0.0 0.74 10.3 0.0 2.5 2 0 0 2 2 2 0 CoA binding domain LAL_C2 PF18603.1 ORX62453.1 - 0.12 12.5 0.0 0.75 10.0 0.0 2.3 2 0 0 2 2 2 0 L-amino acid ligase C-terminal domain 2 SecD_SecF PF02355.16 ORX62454.1 - 0.033 13.6 1.2 0.043 13.2 1.2 1.1 1 0 0 1 1 1 0 Protein export membrane protein Pkinase PF00069.25 ORX62455.1 - 2.3e-62 210.8 0.0 2.9e-62 210.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62455.1 - 1.3e-31 109.9 0.0 1.7e-31 109.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62455.1 - 2.3e-05 23.8 0.0 3.3e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ORX62455.1 - 8.1e-05 21.6 0.0 0.00052 18.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX62455.1 - 0.0056 16.2 0.1 0.019 14.5 0.0 1.8 1 1 1 2 2 2 1 PhoP regulatory network protein YrbL APH PF01636.23 ORX62455.1 - 0.032 14.2 0.0 0.27 11.1 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family EMP24_GP25L PF01105.24 ORX62456.1 - 5.2e-42 143.9 0.3 6.3e-42 143.6 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SIR2 PF02146.17 ORX62457.1 - 2.1e-63 213.4 0.0 2.9e-63 213.0 0.0 1.2 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 ORX62457.1 - 1.9e-06 27.8 5.0 4.5e-06 26.5 3.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 ORX62457.1 - 0.005 16.6 0.2 0.17 11.6 0.0 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain CutC PF03932.14 ORX62457.1 - 0.017 14.6 0.1 0.15 11.5 0.0 2.1 2 0 0 2 2 2 0 CutC family SDA1 PF05285.12 ORX62457.1 - 9.9 5.5 8.7 14 5.0 8.7 1.1 1 0 0 1 1 1 0 SDA1 Adap_comp_sub PF00928.21 ORX62458.1 - 1.9e-23 83.2 0.1 3.4e-23 82.4 0.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ORX62458.1 - 3.7e-08 33.4 0.4 6e-08 32.7 0.4 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4337 PF14235.6 ORX62458.1 - 0.026 14.6 1.9 0.045 13.9 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MBR1 PF17058.5 ORX62458.1 - 0.047 14.0 0.4 0.075 13.3 0.4 1.4 1 0 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 RE_HindIII PF09518.10 ORX62458.1 - 0.1 11.8 0.6 0.15 11.2 0.6 1.3 1 0 0 1 1 1 0 HindIII restriction endonuclease Chitin_synth_2 PF03142.15 ORX62459.1 - 3.7e-276 916.8 0.8 5.2e-276 916.3 0.8 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 ORX62459.1 - 1.1e-11 45.0 5.4 7e-11 42.4 5.4 2.4 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 ORX62459.1 - 1.5e-11 44.6 0.0 2.4e-10 40.7 0.0 2.6 3 1 0 3 3 3 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 ORX62459.1 - 4.6e-05 23.3 0.0 0.12 12.1 0.0 3.3 3 0 0 3 3 3 2 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 ORX62459.1 - 0.0015 18.0 0.1 0.17 11.3 0.0 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 21 Cyt-b5 PF00173.28 ORX62459.1 - 0.0036 17.4 0.0 2.6 8.3 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain ECH_1 PF00378.20 ORX62463.1 - 3.6e-46 157.5 0.7 3.8e-45 154.2 0.7 1.9 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ORX62463.1 - 4e-26 92.3 0.7 1.6e-23 83.7 0.4 2.5 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DUF1706 PF08020.11 ORX62463.1 - 0.021 14.7 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1706) zf-UBR PF02207.20 ORX62464.1 - 3e-19 68.9 11.4 3e-19 68.9 11.4 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 ORX62464.1 - 2.4e-11 43.3 0.1 7.5e-11 41.7 0.1 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_5 PF14634.6 ORX62464.1 - 0.0025 17.7 0.3 0.0025 17.7 0.3 3.8 4 0 0 4 4 4 1 zinc-RING finger domain DUF1682 PF07946.14 ORX62464.1 - 0.076 12.2 1.2 0.14 11.3 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DMRT-like PF15791.5 ORX62464.1 - 0.098 13.1 2.0 0.41 11.1 2.0 2.1 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 DUF1764 PF08576.10 ORX62465.1 - 2.8e-17 63.4 11.5 2.8e-17 63.4 11.5 2.5 1 1 1 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) Mif2_N PF15624.6 ORX62465.1 - 0.36 11.5 7.5 0.05 14.3 3.3 1.6 1 1 1 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal GTP_EFTU PF00009.27 ORX62468.1 - 3.9e-36 124.4 4.0 2.3e-34 118.7 4.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ORX62468.1 - 6.5e-30 103.4 2.6 1.7e-29 102.0 2.6 1.7 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 ORX62468.1 - 5e-10 39.5 0.1 1.5e-09 37.9 0.1 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ORX62468.1 - 4.1e-06 27.1 1.9 0.0031 17.9 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 FeoB_N PF02421.18 ORX62468.1 - 0.0024 17.4 0.2 0.01 15.4 0.2 2.0 1 1 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ORX62468.1 - 0.0031 17.4 1.8 0.48 10.3 0.0 2.8 1 1 1 2 2 2 2 RsgA GTPase SRPRB PF09439.10 ORX62468.1 - 0.018 14.5 0.1 0.018 14.5 0.1 2.2 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF966 PF06136.13 ORX62468.1 - 7.4 6.2 18.7 2.2 7.9 14.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF966) RNase_P_p30 PF01876.16 ORX62469.1 - 3.9e-42 144.1 0.1 5.4e-42 143.7 0.1 1.3 1 0 0 1 1 1 1 RNase P subunit p30 Tom37 PF10568.9 ORX62470.1 - 1.6e-19 70.4 0.0 2.7e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 ORX62470.1 - 6.7e-15 55.6 0.0 1.7e-14 54.4 0.0 1.6 2 0 0 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 ORX62470.1 - 0.0075 16.0 0.0 0.026 14.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain E2F_TDP PF02319.20 ORX62471.1 - 1.3e-23 82.8 0.0 2.4e-23 82.0 0.0 1.5 1 0 0 1 1 1 1 E2F/DP family winged-helix DNA-binding domain E2F_CC-MB PF16421.5 ORX62471.1 - 8.4e-05 22.9 0.4 0.00013 22.2 0.4 1.3 1 0 0 1 1 1 1 E2F transcription factor CC-MB domain Stathmin PF00836.19 ORX62471.1 - 0.0021 18.0 0.4 0.0031 17.5 0.4 1.3 1 0 0 1 1 1 1 Stathmin family FliD_N PF02465.18 ORX62471.1 - 0.0096 16.6 0.2 0.021 15.5 0.2 1.6 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus ZapB PF06005.12 ORX62471.1 - 0.014 15.8 2.1 0.028 14.9 2.1 1.4 1 0 0 1 1 1 0 Cell division protein ZapB DUF2802 PF10975.8 ORX62471.1 - 0.037 14.2 5.2 0.071 13.2 5.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) UPF0122 PF04297.14 ORX62471.1 - 0.075 13.3 1.0 0.22 11.8 0.0 1.9 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like MctB PF11382.8 ORX62471.1 - 1.3 8.6 3.5 2 8.1 3.5 1.2 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB APC_u15 PF16636.5 ORX62471.1 - 3.2 8.2 6.4 2.1 8.8 3.3 2.0 2 0 0 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 PAP_fibrillin PF04755.12 ORX62472.1 - 0.033 14.1 0.1 0.081 12.9 0.1 1.6 1 1 1 2 2 2 0 PAP_fibrillin Snapin_Pallidin PF14712.6 ORX62472.1 - 0.16 12.4 2.3 6.3 7.3 0.0 2.2 2 0 0 2 2 2 0 Snapin/Pallidin RCC1 PF00415.18 ORX62473.1 - 5e-39 132.7 13.3 3.3e-07 30.8 0.0 7.5 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ORX62473.1 - 7.5e-20 70.2 33.0 2.7e-07 30.2 0.0 7.3 9 0 0 9 9 9 5 Regulator of chromosome condensation (RCC1) repeat TMEM240 PF15207.6 ORX62473.1 - 0.038 13.7 0.1 0.062 13.0 0.1 1.2 1 0 0 1 1 1 0 TMEM240 family Pkinase PF00069.25 ORX62474.1 - 3.1e-68 230.0 0.0 3.5e-68 229.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62474.1 - 2.6e-35 122.0 0.0 3.1e-35 121.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62474.1 - 3.1e-09 36.6 0.0 4.1e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ORX62474.1 - 4.9e-06 26.3 0.0 6.9e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 ORX62474.1 - 0.00012 21.1 0.1 0.00015 20.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX62474.1 - 0.00019 20.8 0.0 0.00029 20.3 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX62474.1 - 0.00031 20.7 0.0 0.034 14.1 0.1 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ORX62474.1 - 0.0013 18.4 0.2 0.0021 17.7 0.2 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ORX62474.1 - 0.013 14.3 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ORX62474.1 - 0.018 14.6 0.1 0.026 14.1 0.1 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 ORX62474.1 - 0.04 13.5 0.1 0.058 13.0 0.1 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 FCSD-flav_bind PF09242.11 ORX62474.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Flavocytochrome c sulphide dehydrogenase, flavin-binding E1_dh PF00676.20 ORX62476.1 - 4e-87 291.9 1.3 4.6e-87 291.8 1.3 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component ComA PF02679.15 ORX62476.1 - 0.11 11.9 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 (2R)-phospho-3-sulfolactate synthase (ComA) MFS_1 PF07690.16 ORX62477.1 - 1.9e-35 122.5 45.8 1.8e-34 119.2 45.8 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX62477.1 - 9.4e-14 51.1 8.0 9.4e-14 51.1 8.0 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter GTP_EFTU PF00009.27 ORX62478.1 - 2.7e-66 222.8 0.1 3.8e-66 222.3 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX62478.1 - 7.8e-31 106.4 0.0 2.4e-30 104.8 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ORX62478.1 - 1.1e-21 76.6 0.0 2.7e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ORX62478.1 - 2.2e-12 46.9 0.0 5e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ORX62478.1 - 2.7e-12 46.9 0.1 7.9e-12 45.4 0.1 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX62478.1 - 0.00092 19.3 0.1 0.0022 18.0 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ORX62478.1 - 0.16 11.7 0.1 0.66 9.7 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SMN PF06003.12 ORX62526.1 - 7e-05 22.2 8.6 0.0089 15.3 2.5 2.0 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) EHN PF06441.12 ORX62526.1 - 0.043 14.2 0.4 0.075 13.4 0.0 1.5 2 0 0 2 2 2 0 Epoxide hydrolase N terminus DUF1201 PF06716.11 ORX62527.1 - 0.029 14.4 0.8 0.12 12.4 0.8 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) Arm PF00514.23 ORX62528.1 - 1.5e-76 250.3 27.3 3.3e-12 46.0 0.1 10.3 10 0 0 10 10 10 10 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ORX62528.1 - 3.7e-18 65.7 11.8 0.00011 22.5 0.1 6.3 2 1 3 6 6 6 5 HEAT repeats HEAT_EZ PF13513.6 ORX62528.1 - 1.7e-15 57.2 20.0 0.00019 21.9 0.2 7.8 7 1 1 8 8 7 4 HEAT-like repeat Adaptin_N PF01602.20 ORX62528.1 - 2.4e-15 56.1 14.5 3.1e-11 42.5 2.1 2.1 1 1 1 2 2 2 2 Adaptin N terminal region HEAT PF02985.22 ORX62528.1 - 2.1e-13 49.3 18.2 0.21 12.0 0.0 8.8 9 0 0 9 9 9 3 HEAT repeat KAP PF05804.12 ORX62528.1 - 1.8e-11 42.9 5.0 2.5e-11 42.5 5.0 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Arm_2 PF04826.13 ORX62528.1 - 1.3e-09 38.0 16.1 3.2e-07 30.1 4.4 3.3 1 1 2 3 3 3 2 Armadillo-like V-ATPase_H_N PF03224.14 ORX62528.1 - 3.5e-07 29.8 6.9 0.0019 17.6 2.5 2.9 1 1 1 2 2 2 2 V-ATPase subunit H DUF3361 PF11841.8 ORX62528.1 - 2.2e-06 27.7 9.6 0.082 12.8 0.1 3.5 2 1 1 3 3 3 3 Domain of unknown function (DUF3361) Cnd1 PF12717.7 ORX62528.1 - 2e-05 24.7 12.1 0.026 14.6 0.9 4.2 2 2 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 ORX62528.1 - 0.0002 21.3 8.8 0.36 10.8 0.1 3.9 1 1 2 4 4 4 2 Myosin-binding striated muscle assembly central V-ATPase_H_C PF11698.8 ORX62528.1 - 0.0003 20.9 9.0 0.97 9.6 0.3 4.8 1 1 5 6 6 6 3 V-ATPase subunit H Vac14_Fab1_bd PF12755.7 ORX62528.1 - 0.0011 19.5 1.3 4.2 8.0 0.2 4.2 2 1 2 4 4 4 1 Vacuolar 14 Fab1-binding region RTTN_N PF14726.6 ORX62528.1 - 0.0073 17.1 0.5 0.36 11.7 0.0 2.9 2 0 0 2 2 2 1 Rotatin, an armadillo repeat protein, centriole functioning RTP1_C1 PF10363.9 ORX62528.1 - 0.015 15.5 2.2 3.9 7.7 0.1 3.5 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ORX62528.1 - 0.024 15.3 9.9 41 5.3 0.0 6.8 7 1 0 7 7 6 0 PBS lyase HEAT-like repeat YqfD PF06898.11 ORX62528.1 - 0.12 11.2 0.0 0.25 10.1 0.0 1.5 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD Atx10homo_assoc PF09759.9 ORX62528.1 - 0.49 10.5 8.6 0.71 9.9 0.3 4.1 1 1 3 5 5 5 0 Spinocerebellar ataxia type 10 protein domain NopRA1 PF16201.5 ORX62528.1 - 1 8.9 7.3 3.3 7.2 0.3 3.9 4 0 0 4 4 4 0 Nucleolar pre-ribosomal-associated protein 1 PolyA_pol PF01743.20 ORX62529.1 - 1.4e-15 57.8 0.1 2.3e-15 57.2 0.1 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 ORX62529.1 - 9.8e-08 31.6 0.0 2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A VWA PF00092.28 ORX62530.1 - 2.4e-06 27.9 8.7 0.00011 22.5 1.2 3.9 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 ORX62530.1 - 0.01 16.4 0.2 0.01 16.4 0.2 3.9 4 0 0 4 4 4 0 von Willebrand factor type A domain AAA_5 PF07728.14 ORX62531.1 - 2e-130 429.5 0.3 3e-27 95.3 0.0 8.6 8 0 0 8 8 8 8 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ORX62531.1 - 7.4e-58 193.3 5.1 3.1e-21 75.5 0.1 6.3 6 0 0 6 6 5 3 Midasin AAA lid domain AAA_lid_5 PF17865.1 ORX62531.1 - 3.2e-36 123.6 0.6 1.5e-35 121.5 0.1 2.5 2 0 0 2 2 1 1 Midasin AAA lid domain AAA_3 PF07726.11 ORX62531.1 - 4.3e-31 107.5 0.0 1.5e-07 31.4 0.0 7.0 7 0 0 7 7 6 4 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ORX62531.1 - 2.4e-28 99.2 0.0 9e-05 22.9 0.0 6.8 6 0 0 6 6 6 4 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ORX62531.1 - 4e-27 94.9 6.6 1.4e-05 24.7 0.1 6.7 6 0 0 6 6 6 5 P-loop containing dynein motor region AAA_16 PF13191.6 ORX62531.1 - 1.1e-24 87.8 10.7 0.0002 21.8 0.3 8.4 6 2 0 6 6 6 5 AAA ATPase domain AAA_6 PF12774.7 ORX62531.1 - 1.3e-22 80.2 5.5 0.0043 16.1 0.3 7.9 7 1 0 7 7 7 5 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 ORX62531.1 - 1.7e-22 79.8 0.0 0.00076 19.6 0.0 8.0 8 0 0 8 8 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 ORX62531.1 - 2e-22 79.9 2.8 0.00018 21.8 0.0 7.9 8 0 0 8 8 6 3 AAA domain AAA_18 PF13238.6 ORX62531.1 - 2.9e-21 76.4 0.2 0.032 14.8 0.0 7.0 6 0 0 6 6 6 4 AAA domain Sigma54_activat PF00158.26 ORX62531.1 - 1.5e-20 73.5 0.1 0.0011 18.8 0.1 6.8 6 1 0 6 6 6 5 Sigma-54 interaction domain AAA_14 PF13173.6 ORX62531.1 - 5.1e-19 68.6 0.0 0.0017 18.4 0.0 7.3 7 0 0 7 7 7 3 AAA domain ABC_tran PF00005.27 ORX62531.1 - 1.3e-18 67.8 0.2 0.0034 17.9 0.0 6.9 6 0 0 6 6 6 3 ABC transporter TsaE PF02367.17 ORX62531.1 - 1.6e-16 60.5 4.9 0.055 13.5 0.0 6.4 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ORX62531.1 - 2.6e-16 59.9 0.3 0.0016 18.2 0.0 7.7 7 1 0 7 7 6 3 AAA domain AAA_33 PF13671.6 ORX62531.1 - 1.6e-14 54.3 0.6 1 9.5 0.0 7.2 6 1 0 6 6 6 3 AAA domain Zeta_toxin PF06414.12 ORX62531.1 - 3e-14 52.8 1.2 0.15 11.3 0.0 7.0 6 0 0 6 6 6 3 Zeta toxin Sigma54_activ_2 PF14532.6 ORX62531.1 - 9.8e-14 51.6 0.7 0.0005 20.2 0.0 6.1 7 0 0 7 7 5 2 Sigma-54 interaction domain RsgA_GTPase PF03193.16 ORX62531.1 - 1.4e-13 51.1 1.1 0.25 11.2 0.1 6.8 6 0 0 6 6 6 2 RsgA GTPase Rad17 PF03215.15 ORX62531.1 - 1.2e-12 48.1 0.1 0.11 12.4 0.0 5.2 5 0 0 5 5 5 3 Rad17 P-loop domain RNA_helicase PF00910.22 ORX62531.1 - 1.7e-12 47.7 0.9 0.092 13.1 0.0 6.4 6 0 0 6 6 6 2 RNA helicase AAA_28 PF13521.6 ORX62531.1 - 1.8e-12 47.8 2.5 1.6 9.0 0.0 6.8 6 0 0 6 6 6 2 AAA domain AAA_29 PF13555.6 ORX62531.1 - 8.9e-12 44.6 0.3 1.9 8.3 0.0 7.0 6 0 0 6 6 6 1 P-loop containing region of AAA domain RuvB_N PF05496.12 ORX62531.1 - 2.7e-11 43.4 0.5 2.5 7.8 0.0 7.6 8 0 0 8 8 7 0 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 ORX62531.1 - 7e-11 42.1 5.8 0.41 10.2 0.0 6.2 7 0 0 7 7 5 2 AAA domain AAA_2 PF07724.14 ORX62531.1 - 9.4e-11 42.1 0.4 1.5 8.9 0.0 6.5 6 0 0 6 6 6 1 AAA domain (Cdc48 subfamily) T2SSE PF00437.20 ORX62531.1 - 1.1e-10 41.0 1.4 0.62 9.1 0.0 6.3 6 0 0 6 6 6 2 Type II/IV secretion system protein DUF815 PF05673.13 ORX62531.1 - 1.3e-09 37.6 1.2 0.56 9.3 0.0 5.9 6 0 0 6 6 6 3 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ORX62531.1 - 7.2e-09 35.5 5.5 0.018 14.8 0.0 5.6 6 0 0 6 6 6 2 Ethanolamine utilisation - propanediol utilisation Mg_chelatase PF01078.21 ORX62531.1 - 1.1e-08 34.7 7.1 0.32 10.4 0.0 7.7 9 1 0 9 9 7 1 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ORX62531.1 - 1.9e-08 34.4 12.6 0.052 13.5 0.0 7.2 9 0 0 9 9 5 2 NACHT domain AAA_23 PF13476.6 ORX62531.1 - 3.6e-08 34.2 5.9 6.8 7.1 0.0 6.8 6 1 0 6 6 6 0 AAA domain AAA_19 PF13245.6 ORX62531.1 - 4e-08 33.7 5.5 0.034 14.5 0.1 6.0 6 0 0 6 6 5 1 AAA domain CPT PF07931.12 ORX62531.1 - 4.3e-08 33.2 3.6 0.29 10.9 0.0 7.8 8 1 0 8 8 7 1 Chloramphenicol phosphotransferase-like protein Roc PF08477.13 ORX62531.1 - 7.8e-08 32.6 2.3 5.3 7.3 0.0 6.5 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ORX62531.1 - 1.9e-07 31.2 0.1 14 5.8 0.0 6.8 7 0 0 7 7 7 0 50S ribosome-binding GTPase cobW PF02492.19 ORX62531.1 - 2.4e-07 30.5 1.1 5.7 6.5 0.1 6.3 6 0 0 6 6 6 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 ORX62531.1 - 5.9e-07 29.5 0.0 1.4 8.6 0.0 5.3 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 ORX62531.1 - 6e-07 29.4 0.4 7 6.3 0.0 5.7 6 1 0 6 6 5 0 AAA domain dNK PF01712.19 ORX62531.1 - 9.2e-07 28.9 5.6 3.5 7.4 0.0 6.9 7 0 0 7 7 6 0 Deoxynucleoside kinase IstB_IS21 PF01695.17 ORX62531.1 - 1.3e-06 28.3 0.2 0.6 9.8 0.0 5.9 6 0 0 6 6 6 1 IstB-like ATP binding protein SRP54 PF00448.22 ORX62531.1 - 1.6e-06 27.9 9.6 0.2 11.2 0.0 5.9 7 0 0 7 7 5 2 SRP54-type protein, GTPase domain DAP3 PF10236.9 ORX62531.1 - 2e-06 27.2 0.7 1.7 7.8 0.1 4.5 4 0 0 4 4 4 1 Mitochondrial ribosomal death-associated protein 3 TniB PF05621.11 ORX62531.1 - 2.8e-06 26.9 0.2 1.7 8.0 0.0 5.2 6 0 0 6 6 4 1 Bacterial TniB protein AAA_9 PF12781.7 ORX62531.1 - 7.2e-06 25.3 0.0 0.71 9.0 0.0 4.7 5 0 0 5 5 5 1 ATP-binding dynein motor region SRPRB PF09439.10 ORX62531.1 - 1.4e-05 24.6 1.0 9.9 5.6 0.0 5.5 6 0 0 6 6 5 0 Signal recognition particle receptor beta subunit ATPase_2 PF01637.18 ORX62531.1 - 1.4e-05 25.1 0.2 3.1 7.6 0.0 5.5 5 1 0 5 5 5 0 ATPase domain predominantly from Archaea G-alpha PF00503.20 ORX62531.1 - 2.1e-05 23.9 0.9 0.77 8.8 0.0 4.4 4 0 0 4 4 4 1 G-protein alpha subunit AAA_8 PF12780.7 ORX62531.1 - 2.3e-05 23.8 2.2 3.1 7.1 0.0 5.7 7 0 0 7 7 5 0 P-loop containing dynein motor region D4 ATP_bind_1 PF03029.17 ORX62531.1 - 6.4e-05 22.9 8.2 0.19 11.5 0.0 5.3 6 0 0 6 6 5 1 Conserved hypothetical ATP binding protein ATP-synt_ab PF00006.25 ORX62531.1 - 8e-05 22.4 0.0 1.8 8.2 0.0 3.8 5 0 0 5 5 3 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_15 PF13175.6 ORX62531.1 - 0.00082 19.2 0.0 3.6 7.2 0.0 3.7 3 1 0 3 3 3 0 AAA ATPase domain PRK PF00485.18 ORX62531.1 - 0.00093 19.0 0.2 9.6 5.9 0.0 4.2 4 0 0 4 4 3 0 Phosphoribulokinase / Uridine kinase family NTPase_1 PF03266.15 ORX62531.1 - 0.0012 18.8 8.5 3.4 7.6 0.1 5.3 7 0 0 7 7 4 0 NTPase Cytidylate_kin PF02224.18 ORX62531.1 - 0.0017 18.2 0.0 16 5.1 0.0 4.2 4 0 0 4 4 4 0 Cytidylate kinase ResIII PF04851.15 ORX62531.1 - 0.0018 18.3 4.2 1.8 8.5 0.0 4.5 5 0 0 5 5 5 1 Type III restriction enzyme, res subunit tRNA_lig_kinase PF08303.11 ORX62531.1 - 0.0019 18.3 0.1 1.9 8.6 0.0 2.8 2 0 0 2 2 2 1 tRNA ligase kinase domain ATPase PF06745.13 ORX62531.1 - 0.0021 17.5 0.2 11 5.3 0.0 4.5 5 0 0 5 5 4 0 KaiC KAP_NTPase PF07693.14 ORX62531.1 - 0.0025 17.1 0.0 5.5 6.1 0.0 4.4 4 0 0 4 4 4 0 KAP family P-loop domain DEAD PF00270.29 ORX62531.1 - 0.0046 16.7 1.6 16 5.2 0.0 4.7 6 0 0 6 6 4 0 DEAD/DEAH box helicase Thymidylate_kin PF02223.17 ORX62531.1 - 0.0047 16.6 2.1 5.1 6.7 0.1 4.5 4 0 0 4 4 3 0 Thymidylate kinase TIP49 PF06068.13 ORX62531.1 - 0.005 16.1 0.2 11 5.1 0.1 4.6 5 0 0 5 5 5 0 TIP49 P-loop domain NB-ARC PF00931.22 ORX62531.1 - 0.0054 15.9 0.2 3.6 6.7 0.0 3.9 3 0 0 3 3 3 0 NB-ARC domain SKI PF01202.22 ORX62531.1 - 0.01 16.0 0.6 11 6.1 0.0 4.3 4 0 0 4 4 3 0 Shikimate kinase Bac_DnaA PF00308.18 ORX62531.1 - 0.01 15.7 0.2 39 4.0 0.0 4.3 5 0 0 5 5 3 0 Bacterial dnaA protein AAA_17 PF13207.6 ORX62531.1 - 0.011 16.1 3.6 1.7 9.1 0.0 4.5 5 0 0 5 5 3 0 AAA domain FeoB_N PF02421.18 ORX62531.1 - 0.026 14.0 1.2 23 4.5 0.0 4.2 5 0 0 5 5 3 0 Ferrous iron transport protein B Septin PF00735.18 ORX62531.1 - 0.03 13.6 1.0 21 4.3 0.0 3.9 5 0 0 5 5 3 0 Septin MobB PF03205.14 ORX62531.1 - 0.039 13.8 4.7 7.8 6.4 0.0 5.1 6 0 0 6 6 5 0 Molybdopterin guanine dinucleotide synthesis protein B TrwB_AAD_bind PF10412.9 ORX62531.1 - 0.052 12.5 2.4 4.8 6.0 0.0 4.2 5 0 0 5 5 4 0 Type IV secretion-system coupling protein DNA-binding domain Ras PF00071.22 ORX62531.1 - 0.085 12.4 0.5 27 4.3 0.0 4.0 4 0 0 4 4 4 0 Ras family IPT PF01745.16 ORX62531.1 - 0.14 11.6 3.6 4.4 6.6 0.0 4.4 6 0 0 6 6 4 0 Isopentenyl transferase AAA_21 PF13304.6 ORX62531.1 - 0.14 11.9 0.0 12 5.6 0.0 3.8 5 0 0 5 5 4 0 AAA domain, putative AbiEii toxin, Type IV TA system Nucleoporin_FG2 PF15967.5 ORX62533.1 - 1.8 7.0 9.6 2.3 6.7 9.6 1.2 1 0 0 1 1 1 0 Nucleoporin FG repeated region Trs65 PF12735.7 ORX62534.1 - 1.9e-47 162.3 0.2 1.9e-47 162.3 0.2 1.9 2 1 1 3 3 3 1 TRAPP trafficking subunit Trs65 A2M PF00207.22 ORX62534.1 - 0.076 12.9 0.3 0.27 11.1 0.0 2.1 2 0 0 2 2 2 0 Alpha-2-macroglobulin family PilJ PF13675.6 ORX62534.1 - 0.21 11.7 0.8 3.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term CN_hydrolase PF00795.22 ORX62535.1 - 6.7e-42 143.6 0.0 3.6e-41 141.2 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase RecO_N_2 PF13114.6 ORX62535.1 - 0.084 12.6 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 RecO N terminal adh_short PF00106.25 ORX62536.1 - 2.3e-55 187.1 0.3 2.8e-55 186.8 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX62536.1 - 2.7e-41 141.6 0.3 3.3e-41 141.4 0.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX62536.1 - 9.1e-13 48.5 0.7 1.2e-12 48.1 0.7 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ORX62536.1 - 0.0014 18.6 0.9 0.0019 18.1 0.9 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ORX62536.1 - 0.0018 17.5 0.2 0.0027 16.9 0.2 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 ORX62536.1 - 0.033 13.7 0.4 0.11 12.0 0.4 1.9 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family PGI PF00342.19 ORX62537.1 - 1.1e-250 832.3 0.4 1.2e-250 832.1 0.4 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase PsbU PF06514.11 ORX62537.1 - 0.03 14.3 0.0 0.07 13.1 0.0 1.6 1 0 0 1 1 1 0 Photosystem II 12 kDa extrinsic protein (PsbU) CPSase_L_D3 PF02787.19 ORX62537.1 - 0.093 13.1 1.0 0.3 11.4 0.2 2.1 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain CDP-OH_P_transf PF01066.21 ORX62538.1 - 1.1e-17 64.5 0.1 1.1e-17 64.5 0.1 3.1 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase NAD_Gly3P_dh_C PF07479.14 ORX62539.1 - 1.5e-48 164.7 0.1 2.6e-48 163.9 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus NAD_Gly3P_dh_N PF01210.23 ORX62539.1 - 2.7e-47 160.7 0.0 4.3e-47 160.0 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.17 ORX62539.1 - 0.02 15.5 0.0 1.6 9.3 0.1 2.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 ORX62539.1 - 0.14 11.5 0.3 0.29 10.5 0.3 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain SH3_1 PF00018.28 ORX62541.1 - 7.6e-25 86.3 0.0 1.9e-11 43.4 0.0 2.4 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ORX62541.1 - 1.6e-19 69.5 0.0 2.1e-08 33.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ORX62541.1 - 1.3e-13 50.4 0.0 2.6e-07 30.2 0.0 2.6 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 ORX62541.1 - 6.6e-11 42.2 0.1 1.3e-10 41.2 0.1 1.4 1 0 0 1 1 1 1 PX domain PB1 PF00564.24 ORX62541.1 - 1.3e-05 25.0 0.0 2.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Clathrin PF00637.20 ORX62542.1 - 1.1e-25 90.2 1.8 4e-25 88.4 0.1 2.6 3 0 0 3 3 3 1 Region in Clathrin and VPS Vps39_2 PF10367.9 ORX62542.1 - 1.5e-06 28.6 0.0 4.3e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 WD40_like PF17005.5 ORX62542.1 - 8.1e-05 22.1 0.0 0.012 15.0 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain WD40 PF00400.32 ORX62542.1 - 0.0041 17.9 0.0 0.02 15.8 0.0 2.2 1 0 0 1 1 1 1 WD domain, G-beta repeat zf-RING_UBOX PF13445.6 ORX62542.1 - 0.011 15.8 1.4 0.14 12.2 0.1 2.5 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 ORX62542.1 - 0.034 14.5 7.2 0.3 11.5 7.2 2.3 1 1 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ORX62542.1 - 0.088 12.7 0.1 0.088 12.7 0.1 2.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 ANAPC4_WD40 PF12894.7 ORX62542.1 - 0.1 12.9 0.1 1.9 8.9 0.0 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Gly_acyl_tr_N PF06021.11 ORX62542.1 - 0.11 12.6 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 Aralkyl acyl-CoA:amino acid N-acyltransferase zf-RING_5 PF14634.6 ORX62542.1 - 0.11 12.4 4.8 2 8.4 5.0 2.3 1 1 1 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX62542.1 - 0.18 11.7 4.7 0.53 10.2 2.0 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX62542.1 - 0.43 10.4 8.2 0.19 11.5 5.2 2.1 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 ORX62542.1 - 0.45 10.4 7.1 0.34 10.8 3.2 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX62542.1 - 0.97 9.8 6.3 0.28 11.5 2.2 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain TPR_14 PF13428.6 ORX62542.1 - 3.6 8.7 4.5 32 5.7 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62542.1 - 7 7.0 7.4 15 6.0 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DAO PF01266.24 ORX62543.1 - 1.2e-40 140.3 0.0 1.4e-40 140.0 0.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ORX62543.1 - 5.2e-06 26.6 0.0 1.8e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ORX62543.1 - 0.001 18.4 0.0 0.99 8.6 0.0 3.0 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ORX62543.1 - 0.0059 15.9 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 ORX62543.1 - 0.006 15.7 0.1 0.093 11.8 0.0 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A DLH PF01738.18 ORX62544.1 - 7.6e-15 55.0 0.0 1.2e-14 54.4 0.0 1.3 1 1 0 1 1 1 1 Dienelactone hydrolase family CTU2 PF10288.9 ORX62545.1 - 2.5e-13 50.3 0.1 5.8e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 OrfB_Zn_ribbon PF07282.11 ORX62547.1 - 3.1e-09 36.6 0.2 8.9e-09 35.2 0.2 1.8 1 1 0 1 1 1 1 Putative transposase DNA-binding domain EcoRII-N PF09217.10 ORX62547.1 - 0.037 13.8 0.0 0.065 13.0 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease EcoRII, N-terminal HECT PF00632.25 ORX62548.1 - 2.3e-71 240.8 0.0 4.2e-71 239.9 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) RIX1 PF08167.12 ORX62548.1 - 1.8 8.2 5.8 0.47 10.2 0.2 3.0 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis adh_short_C2 PF13561.6 ORX62549.1 - 1e-54 185.6 0.1 1.2e-54 185.4 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ORX62549.1 - 5e-50 169.7 0.1 8.4e-50 169.0 0.2 1.3 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ORX62549.1 - 3.3e-11 43.4 0.8 4e-11 43.2 0.8 1.1 1 0 0 1 1 1 1 KR domain RmlD_sub_bind PF04321.17 ORX62549.1 - 0.0076 15.4 0.0 0.019 14.1 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Glyco_transf_5 PF08323.11 ORX62549.1 - 0.07 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Starch synthase catalytic domain HSP70 PF00012.20 ORX62550.1 - 1.9e-262 871.8 11.5 2.2e-262 871.6 11.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX62550.1 - 6.3e-14 51.5 5.1 2.5e-11 43.0 1.7 2.5 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 ORX62550.1 - 0.016 15.0 0.0 0.045 13.5 0.0 1.8 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 ORX62550.1 - 0.21 12.0 10.5 2.3 8.7 0.1 3.9 3 2 0 3 3 3 0 Cell division protein FtsA Ku_C PF03730.14 ORX62550.1 - 3.4 8.4 5.9 9.1 7.1 5.9 1.8 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm RAMP4 PF06624.12 ORX62551.1 - 1.5e-18 66.6 0.0 1.6e-18 66.5 0.0 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 ISK_Channel PF02060.15 ORX62551.1 - 0.12 12.1 0.0 0.12 12.0 0.0 1.0 1 0 0 1 1 1 0 Slow voltage-gated potassium channel Ras PF00071.22 ORX62552.1 - 1.6e-50 170.8 0.0 1.9e-50 170.6 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX62552.1 - 6.4e-20 71.6 0.0 9.8e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX62552.1 - 1.8e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX62552.1 - 0.012 15.5 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase Gtr1_RagA PF04670.12 ORX62552.1 - 0.022 14.1 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 ORX62552.1 - 0.11 12.2 0.0 4.8 6.9 0.0 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DAO PF01266.24 ORX62553.1 - 2.6e-54 185.2 0.0 3.6e-54 184.7 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX62553.1 - 3.1e-06 26.7 1.7 0.00078 18.8 0.2 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 ORX62553.1 - 1.2e-05 24.1 0.0 0.029 12.9 0.0 2.2 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Thi4 PF01946.17 ORX62553.1 - 3.8e-05 23.1 0.0 7.3e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 ORX62553.1 - 0.00017 21.8 0.2 0.00041 20.5 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ORX62553.1 - 0.0064 15.8 0.2 0.13 11.5 0.1 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_binding_2 PF00890.24 ORX62553.1 - 0.019 14.0 0.3 0.035 13.2 0.3 1.4 1 0 0 1 1 1 0 FAD binding domain Sacchrp_dh_NADP PF03435.18 ORX62553.1 - 0.035 14.4 0.8 0.23 11.7 0.2 2.5 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Lycopene_cycl PF05834.12 ORX62553.1 - 0.045 12.8 0.1 0.082 11.9 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 ORX62553.1 - 0.057 12.3 0.3 0.1 11.4 0.3 1.4 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_9 PF13454.6 ORX62553.1 - 0.088 12.8 0.2 0.19 11.7 0.2 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding HI0933_like PF03486.14 ORX62553.1 - 0.097 11.4 0.1 0.92 8.1 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein TrkA_N PF02254.18 ORX62553.1 - 0.13 12.5 0.1 0.32 11.3 0.1 1.6 1 0 0 1 1 1 0 TrkA-N domain Polysacc_synt_4 PF04669.13 ORX62554.1 - 9.5e-20 70.9 1.8 1.2e-10 41.2 0.3 2.0 1 1 1 2 2 2 2 Polysaccharide biosynthesis Glyco_transf_10 PF00852.19 ORX62555.1 - 9.6e-45 152.5 0.1 1.5e-44 151.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 ORX62555.1 - 5.3e-14 52.6 0.6 3.5e-13 50.0 0.2 2.3 2 0 0 2 2 2 1 Fucosyltransferase, N-terminal Pkinase PF00069.25 ORX62556.1 - 3.8e-72 242.8 0.0 5e-72 242.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62556.1 - 7.2e-34 117.2 0.0 1e-33 116.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ORX62556.1 - 2.2e-11 44.2 3.2 3.7e-11 43.5 2.0 2.1 2 0 0 2 2 2 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 ORX62556.1 - 3.1e-07 29.7 0.0 4.5e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C2 PF00168.30 ORX62556.1 - 0.0034 17.6 0.0 0.0066 16.7 0.0 1.5 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 ORX62556.1 - 0.043 13.1 0.0 0.21 10.8 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Imm7 PF15585.6 ORX62556.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 7 Cnn_1N PF07989.11 ORX62558.1 - 5.7e-07 29.6 9.4 2e-06 27.8 9.4 1.9 1 1 0 1 1 1 1 Centrosomin N-terminal motif 1 FAM110_C PF14160.6 ORX62558.1 - 0.0057 17.7 0.7 0.0057 17.7 0.7 3.1 2 2 0 2 2 2 1 Centrosome-associated C terminus DUF724 PF05266.14 ORX62558.1 - 0.032 14.0 1.0 0.054 13.3 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) JAKMIP_CC3 PF16034.5 ORX62558.1 - 0.038 14.0 5.1 0.068 13.1 5.0 1.6 1 1 0 1 1 1 0 JAKMIP CC3 domain Shugoshin_N PF07558.11 ORX62558.1 - 0.091 12.6 0.3 0.19 11.6 0.3 1.5 1 0 0 1 1 1 0 Shugoshin N-terminal coiled-coil region DUF4472 PF14739.6 ORX62558.1 - 1 10.1 6.4 0.57 10.9 4.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) bZIP_1 PF00170.21 ORX62558.1 - 4.4 7.5 6.9 0.33 11.1 0.4 2.2 2 1 0 2 2 2 0 bZIP transcription factor PDEase_I PF00233.19 ORX62559.1 - 5.7e-79 265.2 0.2 1.2e-78 264.2 0.0 1.6 2 0 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 ORX62559.1 - 4.9e-07 29.9 0.0 2.7e-06 27.5 0.0 2.1 1 1 0 1 1 1 1 Response regulator receiver domain CENP-F_N PF10481.9 ORX62559.1 - 0.0011 18.7 0.2 0.76 9.4 0.0 2.2 2 0 0 2 2 2 2 Cenp-F N-terminal domain LAG1-DNAbind PF09271.11 ORX62561.1 - 3.3e-41 141.4 0.0 1e-40 139.8 0.0 1.9 1 1 0 1 1 1 1 LAG1, DNA binding BTD PF09270.10 ORX62561.1 - 4.7e-23 82.1 0.1 6.4e-13 49.2 0.0 3.4 3 0 0 3 3 3 3 Beta-trefoil DNA-binding domain GCN5L1 PF06320.13 ORX62562.1 - 2.2e-37 127.7 4.8 2.5e-37 127.5 4.8 1.0 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) AAA-ATPase_like PF09820.9 ORX62562.1 - 0.059 12.8 0.5 0.065 12.6 0.5 1.1 1 0 0 1 1 1 0 Predicted AAA-ATPase LPP PF04728.13 ORX62562.1 - 0.12 12.7 2.5 3 8.3 0.0 2.6 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF4570 PF15134.6 ORX62562.1 - 0.36 10.9 4.3 2.5 8.1 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) BrkDBD PF09607.10 ORX62562.1 - 0.37 10.6 2.9 0.7 9.7 0.0 2.3 3 0 0 3 3 3 0 Brinker DNA-binding domain OrfB_Zn_ribbon PF07282.11 ORX62563.1 - 0.00025 20.9 0.1 0.00045 20.1 0.1 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Iron_permease PF04120.12 ORX62564.1 - 0.17 11.7 3.0 0.24 11.2 3.0 1.4 1 1 0 1 1 1 0 Low affinity iron permease Neur_chan_memb PF02932.16 ORX62564.1 - 7.9 6.5 10.5 8.9 6.3 10.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RasGEF PF00617.19 ORX62565.1 - 2.3e-15 57.3 0.1 3.9e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 RasGEF domain PAM2 PF07145.15 ORX62565.1 - 0.036 13.8 0.2 0.087 12.5 0.2 1.7 1 0 0 1 1 1 0 Ataxin-2 C-terminal region Ecm29 PF13001.7 ORX62567.1 - 3.2e-133 445.0 0.0 3.3e-132 441.7 0.0 2.6 3 1 1 4 4 4 1 Proteasome stabiliser HEAT PF02985.22 ORX62567.1 - 2e-12 46.2 11.2 0.0015 18.6 0.1 10.9 11 0 0 11 11 11 2 HEAT repeat HEAT_EZ PF13513.6 ORX62567.1 - 9.8e-11 41.9 6.1 0.2 12.2 0.0 9.5 9 1 1 10 10 10 2 HEAT-like repeat HEAT_2 PF13646.6 ORX62567.1 - 1.4e-07 31.8 2.9 2 8.9 0.0 8.0 8 0 0 8 8 8 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ORX62567.1 - 9.4e-07 29.4 2.1 0.9 10.2 0.0 7.2 7 1 1 8 8 8 2 Vacuolar 14 Fab1-binding region IFRD PF05004.13 ORX62567.1 - 0.0025 17.0 9.6 1.4 8.0 0.5 6.2 4 3 2 6 6 6 1 Interferon-related developmental regulator (IFRD) Arm PF00514.23 ORX62567.1 - 0.0036 17.3 0.1 0.065 13.3 0.0 3.1 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 ORX62567.1 - 0.03 13.9 1.6 6.3 6.3 0.1 4.4 4 1 0 4 4 4 0 CLASP N terminal DNA_alkylation PF08713.11 ORX62567.1 - 0.04 13.6 0.8 1.3 8.6 0.2 2.8 2 0 0 2 2 2 0 DNA alkylation repair enzyme MMS19_C PF12460.8 ORX62567.1 - 0.35 9.9 9.6 6 5.9 0.2 4.9 5 1 0 5 5 5 0 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 ORX62567.1 - 1.4 8.4 11.5 15 5.1 0.1 4.9 6 1 0 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II Urm1 PF09138.11 ORX62568.1 - 2.7e-37 127.0 0.3 3e-37 126.9 0.3 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 ORX62568.1 - 0.00033 21.2 0.0 0.00042 20.9 0.0 1.2 1 0 0 1 1 1 1 ThiS family PTS_IIA PF02255.16 ORX62568.1 - 0.029 14.4 0.0 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Per1 PF04080.13 ORX62568.1 - 0.11 12.2 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Per1-like family ABC_tran PF00005.27 ORX62569.1 - 2e-37 128.7 0.0 3.9e-37 127.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ORX62569.1 - 1.6e-35 123.1 16.6 1.6e-35 123.1 16.6 1.8 2 0 0 2 2 2 1 ABC transporter transmembrane region SMC_N PF02463.19 ORX62569.1 - 5.6e-09 35.8 0.6 1.9e-07 30.7 0.6 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain MTABC_N PF16185.5 ORX62569.1 - 1.3e-06 28.2 11.0 1.3e-06 28.2 11.0 2.1 2 1 0 2 2 2 1 Mitochondrial ABC-transporter N-terminal five TM region AAA_16 PF13191.6 ORX62569.1 - 3.2e-05 24.4 0.0 9.2e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 ORX62569.1 - 0.00052 20.4 0.0 0.012 16.0 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ORX62569.1 - 0.00074 19.8 0.1 0.023 15.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 ORX62569.1 - 0.00088 19.2 0.3 0.0036 17.2 0.1 1.9 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ORX62569.1 - 0.0011 18.9 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_5 PF07728.14 ORX62569.1 - 0.0012 18.8 0.1 0.069 13.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ORX62569.1 - 0.0019 17.9 0.2 0.0046 16.7 0.2 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ORX62569.1 - 0.0037 17.0 0.0 0.0058 16.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ORX62569.1 - 0.019 15.0 0.0 0.47 10.5 0.0 3.0 2 1 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ORX62569.1 - 0.026 14.6 0.1 0.09 12.9 0.1 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Zeta_toxin PF06414.12 ORX62569.1 - 0.028 13.7 0.2 0.078 12.2 0.0 1.8 2 0 0 2 2 1 0 Zeta toxin Guanylate_kin PF00625.21 ORX62569.1 - 0.039 13.6 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase G-alpha PF00503.20 ORX62569.1 - 0.041 13.0 0.0 0.083 12.0 0.0 1.5 1 0 0 1 1 1 0 G-protein alpha subunit AAA_25 PF13481.6 ORX62569.1 - 0.045 13.3 0.1 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ORX62569.1 - 0.045 13.5 0.0 0.091 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ORX62569.1 - 0.054 14.0 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ORX62569.1 - 0.065 12.9 0.0 0.18 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ORX62569.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ORX62569.1 - 0.13 12.8 0.0 0.29 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 ORX62569.1 - 0.15 12.3 0.2 4.4 7.6 0.2 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit APS_kinase PF01583.20 ORX62569.1 - 0.15 11.9 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF2852 PF11014.8 ORX62569.1 - 1.7 8.8 6.6 4 7.6 0.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) LapA_dom PF06305.11 ORX62569.1 - 9.5 6.1 12.0 0.25 11.2 0.5 3.6 4 1 0 4 4 3 0 Lipopolysaccharide assembly protein A domain Pkinase PF00069.25 ORX62571.1 - 3.9e-66 223.1 0.6 5.7e-66 222.6 0.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62571.1 - 3.9e-42 144.3 0.8 5.6e-42 143.8 0.8 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX62571.1 - 5.7e-07 29.1 1.8 1.1e-06 28.2 1.8 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ORX62571.1 - 3.8e-05 23.2 0.1 0.0032 16.8 0.0 2.4 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX62571.1 - 0.0014 18.6 2.4 0.16 11.9 0.0 2.9 2 1 1 3 3 3 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX62571.1 - 0.006 15.6 0.5 0.006 15.6 0.5 2.2 3 0 0 3 3 3 1 Haspin like kinase domain Ank_2 PF12796.7 ORX62572.1 - 1.3e-22 80.2 0.0 1.6e-13 51.0 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ORX62572.1 - 4e-18 63.6 0.3 0.00022 21.4 0.0 5.9 6 0 0 6 6 6 3 Ankyrin repeat Ank_4 PF13637.6 ORX62572.1 - 3e-17 62.7 0.9 1.2e-05 25.7 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX62572.1 - 1.4e-13 50.6 4.7 0.0047 17.3 0.0 6.6 8 0 0 8 8 8 4 Ankyrin repeat Ank_5 PF13857.6 ORX62572.1 - 8.3e-13 48.3 2.3 9.7e-06 25.8 0.0 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Synaptobrevin PF00957.21 ORX62572.1 - 0.02 14.6 1.3 0.039 13.7 1.3 1.4 1 0 0 1 1 1 0 Synaptobrevin DUF4449 PF14613.6 ORX62572.1 - 0.042 14.0 4.1 0.075 13.1 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4449) GrpE PF01025.19 ORX62572.1 - 1.1 8.9 5.2 1.7 8.3 4.4 1.7 2 0 0 2 2 2 0 GrpE DBINO PF13892.6 ORX62572.1 - 2.1 8.7 15.4 0.055 13.8 8.5 1.8 2 0 0 2 2 2 0 DNA-binding domain Zn_clus PF00172.18 ORX62573.1 - 1.2e-07 31.8 14.6 2.2e-07 30.9 14.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Asparaginase PF00710.20 ORX62575.1 - 1.8e-61 207.0 0.0 4e-61 205.9 0.0 1.6 1 1 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 ORX62575.1 - 3.8e-29 101.2 0.1 9.8e-29 99.9 0.1 1.8 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 ORX62575.1 - 1.6e-14 54.2 0.2 2.8e-10 40.6 0.2 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ORX62575.1 - 4e-14 52.5 0.1 3.6e-08 33.5 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ORX62575.1 - 1.9e-12 47.5 0.3 1.3e-05 25.6 0.0 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ORX62575.1 - 7.7e-08 32.4 2.1 6.4e-07 29.5 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 ORX62575.1 - 4.5e-07 29.7 0.9 0.034 14.7 0.0 5.0 5 0 0 5 5 5 1 Ankyrin repeat Pkinase PF00069.25 ORX62577.1 - 1.2e-64 218.2 0.1 1.4e-64 218.0 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62577.1 - 3.6e-17 62.5 0.0 9.6e-17 61.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX62577.1 - 4.9e-06 26.6 0.6 2.8e-05 24.1 0.2 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX62577.1 - 0.005 15.7 0.0 0.014 14.2 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ORX62577.1 - 0.03 13.9 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kdo PF06293.14 ORX62577.1 - 0.043 13.2 0.1 0.072 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LysM PF01476.20 ORX62579.1 - 1.2e-08 34.8 0.1 0.0022 18.0 0.0 2.6 3 0 0 3 3 3 2 LysM domain Interfer-bind PF09294.10 ORX62579.1 - 0.038 14.3 0.7 2.6 8.4 0.2 2.5 2 0 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III Lactamase_B_2 PF12706.7 ORX62580.1 - 1.1e-20 74.1 0.0 2.8e-20 72.7 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ORX62580.1 - 0.0012 18.8 0.0 0.002 18.0 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DEAD PF00270.29 ORX62581.1 - 2.3e-38 131.7 0.1 4.5e-38 130.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX62581.1 - 1.1e-17 64.4 0.0 6.7e-17 61.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-HIT PF04438.16 ORX62581.1 - 0.0032 17.3 1.6 0.0052 16.6 1.6 1.3 1 0 0 1 1 1 1 HIT zinc finger Cellulase PF00150.18 ORX62582.1 - 1.9e-10 40.6 0.3 7.7e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) RasGEF PF00617.19 ORX62583.1 - 1.5e-39 136.1 0.0 4.5e-39 134.5 0.0 1.9 1 0 0 1 1 1 1 RasGEF domain RabGAP-TBC PF00566.18 ORX62584.1 - 2e-33 115.9 0.4 3.5e-33 115.1 0.2 1.4 2 0 0 2 2 2 1 Rab-GTPase-TBC domain DUF1818 PF08848.11 ORX62586.1 - 0.0056 16.8 1.0 0.012 15.7 1.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1818) SKA1 PF07160.12 ORX62586.1 - 0.022 14.6 0.5 0.046 13.6 0.5 1.5 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Neur_chan_memb PF02932.16 ORX62586.1 - 0.023 14.7 0.5 0.031 14.3 0.5 1.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5320 PF17253.2 ORX62586.1 - 0.073 14.1 0.7 0.17 13.0 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5320) ZapB PF06005.12 ORX62586.1 - 0.48 10.9 7.0 3.1 8.3 2.2 2.7 3 0 0 3 3 3 0 Cell division protein ZapB FlxA PF14282.6 ORX62586.1 - 0.78 9.8 11.2 0.34 10.9 1.8 2.5 2 0 0 2 2 2 0 FlxA-like protein DUF2076 PF09849.9 ORX62586.1 - 8.6 6.3 10.9 9.7 6.1 2.6 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-C3HC4_2 PF13923.6 ORX62587.1 - 3.7e-09 36.3 13.6 3.7e-09 36.3 13.6 2.2 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ORX62587.1 - 2.3e-08 33.8 11.3 5.2e-08 32.6 11.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ORX62587.1 - 4.2e-07 30.2 14.5 6.9e-07 29.5 13.0 2.2 2 0 0 2 2 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ORX62587.1 - 9.4e-07 28.8 11.2 9.4e-07 28.8 11.2 2.0 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ORX62587.1 - 1.7e-06 27.8 15.2 1.9e-06 27.6 13.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) BRCT_2 PF16589.5 ORX62587.1 - 2.7e-06 27.7 0.0 0.082 13.3 0.0 2.5 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain zf-RING_5 PF14634.6 ORX62587.1 - 9.3e-06 25.5 13.5 4e-05 23.5 13.6 2.1 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ORX62587.1 - 3.1e-05 24.0 13.9 7.2e-05 22.9 13.9 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING BRCT PF00533.26 ORX62587.1 - 7.8e-05 23.0 0.1 0.047 14.1 0.1 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain zf-rbx1 PF12678.7 ORX62587.1 - 0.00012 22.3 8.1 0.00039 20.6 8.1 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ORX62587.1 - 0.00028 20.7 12.5 0.0068 16.3 13.2 2.6 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 U-box PF04564.15 ORX62587.1 - 0.0031 17.7 0.0 0.0086 16.2 0.0 1.7 1 0 0 1 1 1 1 U-box domain zf-ANAPC11 PF12861.7 ORX62587.1 - 0.013 15.6 5.9 0.029 14.4 5.9 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_10 PF16685.5 ORX62587.1 - 0.021 15.0 9.7 0.062 13.5 9.7 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 NETI PF14044.6 ORX62587.1 - 0.17 11.7 0.2 3.7 7.4 0.1 2.6 3 0 0 3 3 3 0 NETI protein zf-RING_4 PF14570.6 ORX62587.1 - 0.28 11.0 11.1 1.6 8.6 11.5 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ORX62587.1 - 2.1 8.3 6.3 5.1 7.0 6.3 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-P11 PF03854.14 ORX62587.1 - 2.1 8.0 8.9 12 5.6 8.6 2.3 1 1 1 2 2 2 0 P-11 zinc finger DUF4552 PF15089.6 ORX62588.1 - 0.072 12.1 0.0 0.092 11.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4552) F-box PF00646.33 ORX62589.1 - 0.013 15.4 0.1 0.058 13.3 0.0 2.2 2 0 0 2 2 2 0 F-box domain F-box-like PF12937.7 ORX62589.1 - 0.032 14.1 0.0 0.098 12.6 0.0 1.9 1 0 0 1 1 1 0 F-box-like DSPc PF00782.20 ORX62590.1 - 2.4e-24 85.7 0.0 3.7e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ORX62590.1 - 1.7e-08 35.0 0.0 7.5e-07 29.6 0.0 3.0 2 1 0 2 2 2 1 Rhodanese-like domain Y_phosphatase2 PF03162.13 ORX62590.1 - 7.1e-05 22.4 0.0 0.00013 21.6 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ORX62590.1 - 0.00063 19.8 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 ORX62590.1 - 0.0045 17.3 0.1 0.011 16.0 0.1 1.6 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ORX62590.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ATG16 PF08614.11 ORX62591.1 - 0.00074 19.8 2.1 0.00083 19.6 2.1 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF16 PF01519.16 ORX62591.1 - 0.079 13.5 2.3 0.11 13.0 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 Sulfatase_C PF14707.6 ORX62591.1 - 0.099 13.4 0.7 0.14 12.9 0.7 1.3 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DivIC PF04977.15 ORX62591.1 - 3.9 7.3 8.7 1.1 9.0 1.2 2.3 1 1 1 2 2 2 0 Septum formation initiator DnaJ-X PF14308.6 ORX62592.1 - 9.1e-58 195.2 0.3 9.1e-58 195.2 0.3 2.1 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 ORX62592.1 - 5.6e-27 93.7 1.6 5.6e-27 93.7 1.6 2.4 2 0 0 2 2 2 1 DnaJ domain zinc_ribbon_12 PF11331.8 ORX62592.1 - 0.046 13.5 0.2 0.089 12.6 0.2 1.5 1 0 0 1 1 1 0 Probable zinc-ribbon domain DUF4250 PF14056.6 ORX62592.1 - 0.078 12.9 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4250) PEX11 PF05648.14 ORX62592.1 - 0.33 10.4 1.4 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) zf-CCCH PF00642.24 ORX62593.1 - 1e-15 57.2 17.5 5.4e-09 35.8 2.8 3.1 3 0 0 3 3 3 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ORX62593.1 - 4.3e-12 45.7 15.9 1.1e-06 28.5 2.4 3.2 3 0 0 3 3 3 3 Zinc finger domain zf-CCCH_4 PF18044.1 ORX62593.1 - 1.8e-08 34.0 14.6 0.00014 21.6 1.5 3.2 3 0 0 3 3 3 3 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ORX62593.1 - 0.00034 21.0 9.6 0.13 12.8 1.4 3.4 3 1 0 3 3 3 2 RNA-binding, Nab2-type zinc finger PTPS PF01242.19 ORX62593.1 - 0.1 12.6 0.5 0.13 12.3 0.5 1.3 1 0 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase Torus PF16131.5 ORX62593.1 - 0.56 10.9 11.3 0.18 12.5 2.3 2.2 1 1 1 2 2 2 0 Torus domain Pyr_redox_2 PF07992.14 ORX62595.1 - 4.4e-27 95.1 0.0 3.2e-23 82.4 0.0 1.9 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ORX62595.1 - 5.5e-16 58.9 0.0 1.3e-09 38.5 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase RGS PF00615.19 ORX62595.1 - 9.7e-09 35.5 0.1 1.9e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain NAD_binding_8 PF13450.6 ORX62595.1 - 4.1e-07 30.1 0.0 0.031 14.5 0.0 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ORX62595.1 - 5e-07 29.6 0.1 0.024 14.2 0.0 2.7 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ORX62595.1 - 0.00018 20.9 0.0 0.0057 15.9 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX62595.1 - 0.00046 19.4 0.0 0.39 9.8 0.0 2.4 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Lycopene_cycl PF05834.12 ORX62595.1 - 0.00073 18.7 0.0 0.59 9.1 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein FAD_binding_3 PF01494.19 ORX62595.1 - 0.002 17.5 0.0 0.27 10.4 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 ORX62595.1 - 0.004 17.1 0.0 3.2 7.7 0.0 3.5 2 1 1 3 3 3 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 ORX62595.1 - 0.0045 15.9 0.0 0.068 12.0 0.0 2.1 2 0 0 2 2 2 1 Tryptophan halogenase NAD_binding_7 PF13241.6 ORX62595.1 - 0.01 16.3 0.7 4.9 7.6 0.0 3.1 2 2 0 3 3 3 0 Putative NAD(P)-binding DUF1188 PF06690.11 ORX62595.1 - 0.027 14.0 0.0 1 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1188) TrkA_N PF02254.18 ORX62595.1 - 0.028 14.7 0.1 9.3 6.5 0.0 2.6 2 0 0 2 2 2 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ORX62595.1 - 0.031 14.5 0.1 8.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 ORX62595.1 - 0.043 13.1 0.0 3.5 6.9 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain ThiF PF00899.21 ORX62595.1 - 0.058 12.7 0.0 1.6 8.0 0.0 2.3 2 0 0 2 2 2 0 ThiF family Thi4 PF01946.17 ORX62595.1 - 0.064 12.5 0.0 0.5 9.6 0.0 2.2 2 0 0 2 2 2 0 Thi4 family XdhC_C PF13478.6 ORX62595.1 - 0.17 12.4 0.0 0.45 11.0 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain RicinB_lectin_2 PF14200.6 ORX62598.1 - 3.3e-18 66.2 0.7 4.3e-09 37.0 0.1 2.4 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ORX62598.1 - 1.2e-12 48.2 0.1 1.4e-12 47.9 0.1 1.1 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain DNA_pol3_chi PF04364.13 ORX62598.1 - 0.079 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III chi subunit, HolC Gal_GalNac_35kD PF17337.2 ORX62598.1 - 0.081 13.0 0.0 1.8 8.6 0.0 2.1 2 1 0 2 2 2 0 Galactose-inhibitable lectin 35 kDa subunit AMIN PF11741.8 ORX62598.1 - 0.083 13.0 0.3 0.35 11.0 0.3 2.0 1 1 0 1 1 1 0 AMIN domain NIF PF03031.18 ORX62599.1 - 6.6e-44 149.4 0.0 1.1e-43 148.7 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Forkhead PF00250.18 ORX62600.1 - 6e-35 119.4 0.3 1.1e-34 118.5 0.3 1.4 1 0 0 1 1 1 1 Forkhead domain ChAPs PF09295.10 ORX62601.1 - 1.8e-154 514.5 0.2 7.5e-151 502.6 0.0 2.1 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_19 PF14559.6 ORX62601.1 - 2.6e-05 24.6 0.8 2.7 8.5 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62601.1 - 0.0011 19.0 3.9 2.9 8.3 0.1 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62601.1 - 0.03 14.4 7.4 0.8 10.0 0.4 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat Glyco_transf_28 PF03033.20 ORX62601.1 - 0.04 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain TPR_14 PF13428.6 ORX62601.1 - 0.071 14.0 3.9 1.2e+02 4.0 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX62601.1 - 0.072 13.8 2.8 1.1 10.0 1.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 ORX62602.1 - 2.7e-36 123.2 0.7 1.4e-20 72.9 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ORX62602.1 - 0.0028 17.9 0.0 0.22 11.7 0.0 2.7 2 2 1 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 ORX62602.1 - 0.0045 17.1 0.0 5 7.3 0.0 3.0 2 2 0 2 2 2 2 RNA recognition motif OB_RNB PF08206.11 ORX62602.1 - 0.0052 16.4 1.1 2.7 7.7 0.0 2.8 2 1 0 2 2 2 2 Ribonuclease B OB domain DbpA PF03880.15 ORX62602.1 - 0.016 15.1 0.2 3 7.9 0.0 2.4 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_Rrp7 PF17799.1 ORX62602.1 - 0.024 14.4 0.0 0.36 10.6 0.0 2.5 2 1 1 3 3 3 0 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 ORX62602.1 - 0.026 14.6 0.2 0.32 11.1 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif CAF20 PF17052.5 ORX62602.1 - 0.053 13.7 0.4 0.11 12.6 0.4 1.6 1 1 1 2 2 2 0 Cap associated factor TrbH PF07283.11 ORX62602.1 - 0.15 12.3 0.1 19 5.5 0.0 2.5 2 1 1 3 3 3 0 Conjugal transfer protein TrbH RGS PF00615.19 ORX62603.1 - 8e-10 39.0 2.1 6.7e-09 36.0 2.1 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain Herpes_US9 PF06072.11 ORX62603.1 - 0.52 10.2 1.6 1.9 8.4 0.2 2.3 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 Glucan_synthase PF02364.15 ORX62604.1 - 0 1289.1 0.0 0 1288.2 0.0 1.4 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ORX62604.1 - 1.1e-37 129.3 0.1 4.5e-37 127.3 0.0 2.2 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 SMC_Nse1 PF07574.13 ORX62606.1 - 0.048 13.6 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex DUF2315 PF10231.9 ORX62606.1 - 0.27 11.3 2.0 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 Apoptogenic protein 1 Na_Ca_ex PF01699.24 ORX62607.1 - 1.6e-37 128.8 44.0 9e-22 77.7 15.1 2.4 3 0 0 3 3 3 2 Sodium/calcium exchanger protein ATP-synt_8 PF00895.20 ORX62607.1 - 0.024 15.1 0.0 0.024 15.1 0.0 2.8 2 0 0 2 2 2 0 ATP synthase protein 8 NIF PF03031.18 ORX62608.1 - 1.5e-54 184.0 0.2 2.3e-54 183.4 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 ORX62608.1 - 0.035 14.5 0.2 0.27 11.6 0.0 2.1 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase CENP-F_N PF10481.9 ORX62608.1 - 0.17 11.5 0.5 0.24 11.0 0.5 1.1 1 0 0 1 1 1 0 Cenp-F N-terminal domain Arf PF00025.21 ORX62609.1 - 2.8e-65 219.0 0.3 3.5e-65 218.7 0.3 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ORX62609.1 - 3.2e-13 50.0 0.0 4.3e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ORX62609.1 - 5.7e-12 45.5 0.3 1.6e-05 24.3 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ORX62609.1 - 6.9e-09 35.5 0.0 8.1e-09 35.3 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ORX62609.1 - 7e-09 35.4 0.0 1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX62609.1 - 5e-07 29.3 0.0 6.3e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX62609.1 - 1e-06 28.8 0.0 2.1e-06 27.8 0.0 1.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 ORX62609.1 - 0.086 12.8 0.2 0.39 10.6 0.0 1.9 2 0 0 2 2 2 0 NACHT domain PduV-EutP PF10662.9 ORX62609.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DUF155 PF02582.14 ORX62610.1 - 3.2e-55 186.9 0.0 5.3e-55 186.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 zf-HIT PF04438.16 ORX62611.1 - 2.5e-10 40.0 11.4 3.7e-10 39.5 11.4 1.3 1 0 0 1 1 1 1 HIT zinc finger zf-B_box PF00643.24 ORX62611.1 - 0.48 10.6 7.6 0.72 10.1 7.6 1.3 1 0 0 1 1 1 0 B-box zinc finger zf-MYND PF01753.18 ORX62611.1 - 0.57 10.3 13.9 0.93 9.6 13.9 1.3 1 0 0 1 1 1 0 MYND finger C1_2 PF03107.16 ORX62611.1 - 0.64 10.4 8.7 1.1 9.6 8.0 1.8 2 0 0 2 2 2 0 C1 domain Rieske PF00355.26 ORX62612.1 - 1.1e-11 44.4 0.0 2.5e-11 43.3 0.0 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ORX62612.1 - 2e-10 41.0 0.9 2e-10 41.0 0.9 1.9 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region DUF4106 PF13388.6 ORX62612.1 - 0.043 13.1 0.2 0.057 12.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) SUKH-4 PF14435.6 ORX62612.1 - 0.07 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein Nucleo_P87 PF07267.11 ORX62613.1 - 7.7 5.2 6.4 11 4.7 6.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 zf-C2H2 PF00096.26 ORX62614.1 - 1.6e-10 40.8 9.2 7.9e-05 22.9 0.5 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX62614.1 - 2.3e-08 34.1 12.3 6.9e-06 26.3 0.8 4.0 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX62614.1 - 7.5e-06 26.4 8.5 0.025 15.4 0.6 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX62614.1 - 0.0026 18.0 2.3 0.035 14.4 0.9 2.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX62614.1 - 0.024 14.7 5.9 0.46 10.6 1.7 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-Di19 PF05605.12 ORX62614.1 - 0.034 14.4 0.7 0.073 13.4 0.7 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding PyrI_C PF02748.15 ORX62614.1 - 0.065 13.1 0.4 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_11 PF16622.5 ORX62614.1 - 0.31 10.8 4.0 2.6 7.9 0.4 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 ORX62614.1 - 0.69 10.0 3.8 8.2 6.5 0.1 2.7 2 0 0 2 2 2 0 BED zinc finger E1-E2_ATPase PF00122.20 ORX62615.1 - 4.9e-50 169.6 1.8 4.9e-50 169.6 1.8 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX62615.1 - 2.2e-37 128.5 13.4 4.1e-37 127.7 11.4 2.2 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ORX62615.1 - 6.1e-25 88.7 1.9 1.4e-21 77.7 0.2 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX62615.1 - 3.9e-13 48.9 0.0 1e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 ORX62615.1 - 5.1e-12 45.7 0.0 1.1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX62615.1 - 5.7e-08 32.8 3.8 4.1e-06 26.7 1.4 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DUF4743 PF15916.5 ORX62615.1 - 0.1 12.6 0.1 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4743) DUF2742 PF10888.8 ORX62615.1 - 0.12 12.6 0.1 30 5.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2742) PAS_3 PF08447.12 ORX62616.1 - 2.5e-11 43.7 0.0 7.4e-09 35.8 0.0 2.3 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 ORX62616.1 - 3e-08 33.6 0.0 1.1e-06 28.6 0.0 2.2 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 ORX62616.1 - 8.4e-08 32.3 0.0 1.7e-06 28.1 0.1 2.2 2 0 0 2 2 2 1 PAS domain PAS_9 PF13426.7 ORX62616.1 - 0.0001 22.5 0.0 0.00055 20.2 0.0 2.0 2 0 0 2 2 2 1 PAS domain PAS_4 PF08448.10 ORX62616.1 - 0.0063 16.7 0.0 0.32 11.2 0.0 2.4 2 0 0 2 2 2 1 PAS fold PAS_2 PF08446.11 ORX62616.1 - 0.054 14.2 0.0 0.53 11.0 0.0 2.1 2 0 0 2 2 2 0 PAS fold DUF2721 PF11026.8 ORX62617.1 - 9 6.2 7.2 24 4.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) RhoGEF PF00621.20 ORX62618.1 - 5.7e-25 88.6 2.3 5.7e-25 88.6 2.3 2.7 3 0 0 3 3 3 1 RhoGEF domain Nup96 PF12110.8 ORX62619.1 - 2e-15 56.7 3.6 5.9e-15 55.2 3.6 1.9 1 0 0 1 1 1 1 Nuclear protein 96 TPR_12 PF13424.6 ORX62619.1 - 2.1e-10 40.8 16.1 0.023 15.0 0.4 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX62619.1 - 3.2e-09 36.2 14.4 0.0058 16.4 2.7 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62619.1 - 5.6e-09 35.4 17.9 0.028 14.5 1.7 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62619.1 - 2.7e-08 33.3 12.0 0.067 13.2 0.0 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62619.1 - 1.2e-06 28.3 8.3 0.67 10.3 1.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ORX62619.1 - 1.5e-05 24.7 12.6 0.16 11.9 0.3 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX62619.1 - 0.023 15.0 5.7 43 4.8 0.0 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62619.1 - 0.37 11.7 18.7 1.1 10.3 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ORX62619.1 - 0.53 11.0 0.0 0.53 11.0 0.0 5.9 6 1 0 6 6 6 0 Tetratricopeptide repeat Nucleoporin2 PF04096.14 ORX62620.1 - 7.5e-45 152.7 0.0 1.1e-44 152.2 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 ORX62620.1 - 0.012 16.4 34.6 0.012 16.4 34.6 9.6 2 2 6 8 8 8 0 Nucleoporin FG repeat region mRNA_cap_enzyme PF01331.19 ORX62621.1 - 5.3e-52 176.5 0.1 7.2e-52 176.1 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ORX62621.1 - 6.3e-31 107.2 0.0 1.1e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ORX62621.1 - 2e-11 43.9 0.0 5.5e-07 29.4 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain Peptidase_M24 PF00557.24 ORX62622.1 - 4.7e-42 144.1 0.0 7.6e-42 143.4 0.0 1.3 1 1 0 1 1 1 1 Metallopeptidase family M24 DUF3391 PF11871.8 ORX62622.1 - 0.27 11.8 3.0 0.5 10.9 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Coilin_N PF15862.5 ORX62622.1 - 1.4 8.7 6.3 28 4.5 6.8 2.3 2 0 0 2 2 2 0 Coilin N-terminus SPT6_acidic PF14632.6 ORX62622.1 - 4.7 7.9 12.4 0.29 11.7 7.0 1.8 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Pkinase PF00069.25 ORX62623.1 - 7.5e-69 232.0 0.0 9.5e-69 231.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62623.1 - 1.2e-30 106.6 0.0 1.8e-30 106.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX62623.1 - 1.8e-05 23.9 0.0 2.4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX62623.1 - 3.2e-05 23.4 0.1 9.7e-05 21.8 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX62623.1 - 0.00063 19.7 0.0 0.0011 19.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ORX62623.1 - 0.012 14.9 0.0 0.25 10.6 0.0 2.1 1 1 1 2 2 2 0 Kinase-like FTA2 PF13095.6 ORX62623.1 - 0.018 14.6 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ORX62623.1 - 0.062 12.9 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 RIO1 family AA_permease PF00324.21 ORX62624.1 - 3.6e-06 25.9 18.9 4.8e-06 25.4 18.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ORX62624.1 - 3.2e-05 22.9 25.2 4e-05 22.6 25.2 1.1 1 0 0 1 1 1 1 Amino acid permease Abhydrolase_1 PF00561.20 ORX62625.1 - 5.5e-22 78.7 0.0 9.1e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ORX62625.1 - 1.9e-19 71.1 0.0 3.2e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DSPc PF00782.20 ORX62625.1 - 6e-13 48.8 0.0 1.2e-12 47.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Hydrolase_4 PF12146.8 ORX62625.1 - 1.3e-11 44.3 0.1 8.3e-11 41.6 0.0 2.3 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 ORX62625.1 - 0.00012 21.9 0.0 0.35 10.6 0.0 3.2 4 0 0 4 4 4 2 Alpha/beta hydrolase family Y_phosphatase PF00102.27 ORX62625.1 - 0.00091 18.9 0.0 0.002 17.7 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Abhydrolase_2 PF02230.16 ORX62625.1 - 0.0042 16.9 0.1 0.54 10.0 0.1 2.9 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Ser_hydrolase PF06821.13 ORX62625.1 - 0.0093 15.8 0.2 0.028 14.3 0.2 1.8 1 1 0 1 1 1 1 Serine hydrolase PTPlike_phytase PF14566.6 ORX62625.1 - 0.013 15.7 0.0 0.026 14.6 0.0 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF676 PF05057.14 ORX62625.1 - 0.017 14.6 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) DUF1057 PF06342.12 ORX62625.1 - 0.036 13.1 0.0 0.053 12.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) BAAT_C PF08840.11 ORX62625.1 - 0.24 11.3 0.7 1.3 8.9 0.0 2.5 3 1 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal DSPc PF00782.20 ORX62626.1 - 1.5e-08 34.6 0.0 2.3e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ORX62626.1 - 0.00013 22.1 0.1 0.00025 21.2 0.0 1.6 2 0 0 2 2 2 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ORX62626.1 - 0.00013 21.6 0.0 0.0002 21.0 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase UvrB PF12344.8 ORX62626.1 - 0.14 12.0 0.4 0.67 9.8 0.1 2.2 2 0 0 2 2 2 0 Ultra-violet resistance protein B Pkinase PF00069.25 ORX62627.1 - 1.8e-61 207.8 0.0 4e-61 206.7 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62627.1 - 3.2e-35 121.7 0.0 7.5e-35 120.5 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase WWE PF02825.20 ORX62628.1 - 0.0013 19.3 0.3 0.0015 19.1 0.3 1.2 1 0 0 1 1 1 1 WWE domain TBPIP PF07106.13 ORX62629.1 - 2.2e-12 46.7 0.2 2.2e-12 46.7 0.2 2.2 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain DUF4686 PF15742.5 ORX62629.1 - 0.0014 17.9 9.5 0.0016 17.6 9.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4686) Leu_zip PF15294.6 ORX62629.1 - 0.0049 16.4 1.3 0.0049 16.4 1.3 2.1 1 1 1 2 2 2 1 Leucine zipper HTH_20 PF12840.7 ORX62629.1 - 0.071 13.2 0.0 2.5 8.2 0.0 2.4 2 0 0 2 2 2 0 Helix-turn-helix domain DUF724 PF05266.14 ORX62629.1 - 0.11 12.3 4.1 0.15 11.9 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) SPT16 PF08644.11 ORX62629.1 - 0.5 10.5 5.0 0.33 11.1 1.6 1.9 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) FAM76 PF16046.5 ORX62629.1 - 0.62 9.4 4.7 0.74 9.1 4.7 1.2 1 0 0 1 1 1 0 FAM76 protein DivIC PF04977.15 ORX62629.1 - 1.1 9.1 13.0 0.085 12.6 4.3 2.5 1 1 1 2 2 2 0 Septum formation initiator APG6_N PF17675.1 ORX62629.1 - 1.1 9.8 12.2 2.7 8.5 12.2 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region ZapB PF06005.12 ORX62629.1 - 6 7.4 12.7 38 4.8 10.8 2.7 2 1 0 2 2 2 0 Cell division protein ZapB WWE PF02825.20 ORX62630.1 - 0.053 14.1 0.3 0.055 14.1 0.3 1.2 1 0 0 1 1 1 0 WWE domain DUF4722 PF15849.5 ORX62630.1 - 0.18 11.5 0.1 0.21 11.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) Profilin PF00235.19 ORX62631.1 - 2e-48 163.8 0.3 2.3e-48 163.7 0.3 1.0 1 0 0 1 1 1 1 Profilin Fer2_4 PF13510.6 ORX62631.1 - 0.042 13.9 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain SH3_1 PF00018.28 ORX62632.1 - 5e-10 38.8 0.0 8.3e-10 38.1 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ORX62632.1 - 2.9e-08 33.3 0.0 5.3e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ORX62632.1 - 1e-07 31.7 0.2 2.2e-07 30.6 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_10 PF17902.1 ORX62632.1 - 0.0015 18.6 0.0 0.0025 17.8 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 ORX62632.1 - 0.0059 16.9 0.0 0.0098 16.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_4 PF06347.13 ORX62632.1 - 0.006 16.4 0.1 0.017 14.9 0.0 1.8 2 0 0 2 2 2 1 Bacterial SH3 domain GP88 PF17338.2 ORX62632.1 - 0.023 14.2 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 Gene product 88 Peptidase_U4 PF03419.13 ORX62632.1 - 4.9 6.3 10.6 7 5.9 10.6 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA RELT PF12606.8 ORX62632.1 - 6.8 5.8 7.3 0.22 10.6 1.2 1.7 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 Peptidase_M28 PF04389.17 ORX62633.1 - 4.5e-41 140.7 0.0 9.8e-41 139.6 0.0 1.6 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M20 PF01546.28 ORX62633.1 - 7.1e-05 22.6 0.0 0.00023 20.9 0.0 1.9 2 1 0 2 2 2 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 ORX62633.1 - 9.8e-05 21.5 0.0 0.00017 20.7 0.0 1.3 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase AMP-binding PF00501.28 ORX62635.1 - 8.7e-92 307.9 0.0 1.2e-91 307.5 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ORX62635.1 - 2.7e-13 50.7 0.2 9.4e-13 49.0 0.2 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ABC_membrane PF00664.23 ORX62636.1 - 1.5e-46 159.3 11.4 1.9e-46 159.0 11.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ORX62636.1 - 2.6e-35 121.9 0.0 4.5e-35 121.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane_2 PF06472.15 ORX62636.1 - 0.00064 19.2 1.5 0.00095 18.7 1.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 AAA_25 PF13481.6 ORX62636.1 - 0.0025 17.4 0.0 0.03 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 ORX62636.1 - 0.0042 17.0 0.0 0.0091 15.9 0.0 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 ORX62636.1 - 0.0096 16.5 0.8 0.068 13.7 0.2 2.6 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX62636.1 - 0.0097 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX62636.1 - 0.013 15.8 0.0 0.041 14.3 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ORX62636.1 - 0.022 15.0 0.0 0.22 11.8 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ORX62636.1 - 0.031 14.0 0.0 0.043 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ORX62636.1 - 0.037 14.2 1.2 0.13 12.4 0.2 2.3 2 1 1 3 3 3 0 AAA domain G-alpha PF00503.20 ORX62636.1 - 0.044 12.9 0.0 0.14 11.3 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit SMC_N PF02463.19 ORX62636.1 - 0.051 13.0 0.0 0.37 10.2 0.0 2.4 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 ORX62636.1 - 0.071 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Zeta_toxin PF06414.12 ORX62636.1 - 0.073 12.3 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DEAD PF00270.29 ORX62636.1 - 0.12 12.1 0.0 0.49 10.2 0.0 1.9 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF87 PF01935.17 ORX62636.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain Anp1 PF03452.14 ORX62637.1 - 3.9e-80 269.1 0.1 4.5e-80 268.9 0.1 1.0 1 0 0 1 1 1 1 Anp1 SgrT PF15894.5 ORX62637.1 - 0.067 13.2 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT Aldedh PF00171.22 ORX62640.1 - 3.3e-63 213.8 0.0 3.8e-56 190.5 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Peptidase_M66 PF10462.9 ORX62640.1 - 0.048 12.6 0.0 0.075 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase M66 DUF5310 PF17237.2 ORX62641.1 - 1.4e-20 72.8 0.3 1.6e-20 72.6 0.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5310) DUF1708 PF08101.11 ORX62641.1 - 0.024 13.8 0.1 0.027 13.6 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) JTB PF05439.12 ORX62641.1 - 0.12 12.4 0.1 0.13 12.3 0.1 1.1 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Far-17a_AIG1 PF04750.14 ORX62642.1 - 6.8e-29 100.6 15.5 8.5e-29 100.3 15.5 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein 2Fe-2S_thioredx PF01257.19 ORX62643.1 - 1.7e-58 196.6 0.0 2.3e-58 196.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin RhoGAP PF00620.27 ORX62644.1 - 1e-46 158.5 0.1 4.5e-46 156.4 0.0 2.2 2 0 0 2 2 2 1 RhoGAP domain RasGEF_N PF00618.20 ORX62644.1 - 3.2e-21 75.5 3.6 3.1e-12 46.7 0.2 3.6 2 1 0 2 2 2 2 RasGEF N-terminal motif RasGEF PF00617.19 ORX62644.1 - 1.8e-10 41.3 1.4 7.2e-09 36.1 0.3 2.9 2 1 0 2 2 2 1 RasGEF domain PH_9 PF15410.6 ORX62644.1 - 2.2e-09 37.7 0.0 8.5e-09 35.8 0.0 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX62644.1 - 8.1e-08 32.7 0.0 3.3e-07 30.7 0.0 2.1 2 0 0 2 2 2 1 PH domain Stanniocalcin PF03298.13 ORX62645.1 - 1.5e-06 27.7 0.6 1.8e-06 27.4 0.6 1.1 1 0 0 1 1 1 1 Stanniocalcin family PH_TFIIH PF08567.11 ORX62646.1 - 8.5e-19 67.7 0.0 1.8e-18 66.6 0.0 1.6 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 ORX62646.1 - 2.4e-16 59.4 2.8 1.1e-10 41.4 0.2 2.6 2 0 0 2 2 2 2 BSD domain NatB_MDM20 PF09797.9 ORX62646.1 - 0.055 12.4 0.0 0.079 11.9 0.0 1.3 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit HSF_DNA-bind PF00447.17 ORX62647.1 - 5.5e-30 103.9 2.2 6.3e-30 103.6 2.2 1.0 1 0 0 1 1 1 1 HSF-type DNA-binding Cdc6_C PF09079.11 ORX62647.1 - 0.0071 16.3 0.0 0.0095 15.9 0.0 1.1 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain Ets PF00178.22 ORX62647.1 - 0.043 14.3 0.1 0.085 13.3 0.1 1.6 1 1 0 1 1 1 0 Ets-domain Pro_CA PF00484.19 ORX62648.1 - 3.5e-51 173.6 0.7 4.9e-51 173.1 0.7 1.2 1 0 0 1 1 1 1 Carbonic anhydrase SprT-like PF10263.9 ORX62649.1 - 1.4e-26 92.6 0.0 2.2e-26 92.0 0.0 1.3 1 0 0 1 1 1 1 SprT-like family Peptidase_M78 PF06114.13 ORX62649.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 IrrE N-terminal-like domain ADK_lid PF05191.14 ORX62649.1 - 0.089 12.8 0.1 0.089 12.8 0.1 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid WLM PF08325.10 ORX62649.1 - 0.46 10.5 1.5 0.48 10.5 0.3 1.7 2 0 0 2 2 2 0 WLM domain Rep_fac-A_C PF08646.10 ORX62650.1 - 4.7e-47 159.4 3.5 4.7e-47 159.4 3.5 2.7 3 0 0 3 3 3 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ORX62650.1 - 7.2e-32 109.2 1.3 9.1e-31 105.7 0.3 2.7 3 0 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.12 ORX62650.1 - 1.2e-23 83.0 0.2 3.2e-23 81.7 0.2 1.8 1 0 0 1 1 1 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 ORX62650.1 - 5.4e-13 48.7 0.1 2.1e-10 40.4 0.0 2.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 ORX62650.1 - 1e-05 25.4 0.1 0.0005 19.8 0.0 2.9 2 1 0 2 2 2 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 ORX62650.1 - 0.0012 19.1 1.9 0.019 15.2 0.1 3.2 3 0 0 3 3 3 1 Domain of unknown function DUF223 OrfB_Zn_ribbon PF07282.11 ORX62650.1 - 0.011 15.6 1.2 0.031 14.2 1.2 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain tRNA_anti_2 PF13742.6 ORX62650.1 - 0.051 13.8 0.1 2.7 8.2 0.1 3.2 2 1 1 3 3 3 0 OB-fold nucleic acid binding domain zinc-ribbons_6 PF07191.12 ORX62650.1 - 0.074 13.0 3.0 0.14 12.2 3.0 1.4 1 0 0 1 1 1 0 zinc-ribbons IMD PF08397.11 ORX62651.1 - 0.0012 18.3 7.1 0.0017 17.8 7.1 1.1 1 0 0 1 1 1 1 IRSp53/MIM homology domain Arfaptin PF06456.13 ORX62651.1 - 0.011 15.4 1.0 0.011 15.4 1.0 2.4 2 1 0 3 3 3 0 Arfaptin-like domain Filament PF00038.21 ORX62651.1 - 0.12 11.9 14.5 0.019 14.6 8.9 1.9 1 1 0 2 2 2 0 Intermediate filament protein Kinesin_assoc PF16183.5 ORX62651.1 - 0.12 12.5 0.2 0.4 10.8 0.3 1.9 2 0 0 2 2 2 0 Kinesin-associated Med20 PF08612.11 ORX62651.1 - 0.15 11.4 4.1 0.28 10.5 0.4 2.3 2 0 0 2 2 2 0 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Phage_tail_APC PF16778.5 ORX62651.1 - 0.6 10.0 2.8 1.2 9.1 0.5 2.4 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Diphthamide_syn PF01866.17 ORX62651.1 - 1.2 8.6 4.0 0.61 9.5 1.4 1.9 2 1 0 2 2 2 0 Putative diphthamide synthesis protein CENP-F_leu_zip PF10473.9 ORX62651.1 - 2.7 8.0 7.6 3.8 7.5 3.7 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Helo_like_N PF17111.5 ORX62651.1 - 2.8 7.3 8.4 1.8 7.9 1.8 2.7 2 1 1 3 3 3 0 Fungal N-terminal domain of STAND proteins TPR_MLP1_2 PF07926.12 ORX62651.1 - 5.9 7.0 17.3 8.9 6.4 7.7 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ATG22 PF11700.8 ORX62652.1 - 8.4e-98 328.1 18.1 9.8e-98 327.8 18.1 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 ORX62652.1 - 8.5e-12 44.7 32.8 8e-10 38.2 18.8 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily IPK PF03770.16 ORX62653.1 - 2.2e-44 151.7 0.1 7e-43 146.8 0.1 2.1 1 1 0 1 1 1 1 Inositol polyphosphate kinase PRTP PF01366.18 ORX62654.1 - 0.0059 14.7 0.0 0.0097 14.0 0.0 1.2 1 0 0 1 1 1 1 Herpesvirus processing and transport protein Exo84_C PF16528.5 ORX62655.1 - 1.5e-50 171.9 2.9 3.5e-50 170.7 2.9 1.7 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ORX62655.1 - 1.1e-14 54.2 0.1 5.7e-14 52.0 0.1 2.3 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ORX62655.1 - 0.00097 19.2 0.4 0.00097 19.2 0.4 2.6 3 0 0 3 3 3 1 COG (conserved oligomeric Golgi) complex component, COG2 SgrR_N PF12793.7 ORX62655.1 - 0.0044 17.2 0.2 0.018 15.2 0.0 2.2 2 0 0 2 2 2 1 Sugar transport-related sRNA regulator N-term Suv3_N PF18114.1 ORX62655.1 - 0.038 14.1 1.1 0.15 12.1 0.1 2.5 2 1 0 2 2 2 0 Suv3 helical N-terminal domain AAA_33 PF13671.6 ORX62655.1 - 0.19 11.9 1.3 0.49 10.6 0.4 2.2 2 0 0 2 2 2 0 AAA domain DNA_pol3_gamma3 PF12169.8 ORX62655.1 - 1.1 9.2 3.5 30 4.5 0.0 3.5 5 0 0 5 5 5 0 DNA polymerase III subunits gamma and tau domain III Abhydrolase_6 PF12697.7 ORX62656.1 - 1.2e-09 39.1 5.8 1.6e-09 38.7 5.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ORX62656.1 - 4.6e-06 26.5 1.1 1.1e-05 25.2 0.9 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX62656.1 - 0.00013 21.4 1.5 0.00046 19.5 1.5 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 ORX62656.1 - 0.00073 19.4 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase Thioesterase PF00975.20 ORX62656.1 - 0.003 17.7 0.2 0.0042 17.2 0.2 1.2 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ORX62656.1 - 0.015 15.1 0.0 0.052 13.4 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_5 PF12695.7 ORX62656.1 - 0.027 14.2 0.0 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase family LIDHydrolase PF10230.9 ORX62656.1 - 0.043 13.4 0.2 0.078 12.5 0.2 1.5 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase AAA PF00004.29 ORX62658.1 - 3e-85 283.3 0.0 3e-41 140.9 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX62658.1 - 4.1e-29 100.1 0.4 2.5e-16 59.2 0.1 2.4 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 ORX62658.1 - 5.5e-14 52.9 3.9 0.00032 21.1 0.0 4.1 3 2 1 4 4 3 3 AAA ATPase domain RuvB_N PF05496.12 ORX62658.1 - 7.9e-12 45.2 0.2 4.1e-05 23.4 0.1 3.9 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX62658.1 - 6e-11 42.5 0.4 3.4e-05 23.9 0.0 4.1 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX62658.1 - 4.3e-10 40.0 0.1 0.023 15.0 0.0 3.8 3 2 1 4 4 3 2 AAA domain AAA_2 PF07724.14 ORX62658.1 - 3.7e-09 36.9 0.0 0.0002 21.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) Rad17 PF03215.15 ORX62658.1 - 1.2e-07 31.8 0.0 7.5e-05 22.7 0.0 2.9 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_33 PF13671.6 ORX62658.1 - 6.2e-07 29.7 0.0 0.0033 17.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 ORX62658.1 - 1.9e-06 27.9 0.0 0.013 15.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ORX62658.1 - 2.9e-06 27.6 0.0 0.045 14.1 0.0 2.8 2 0 0 2 2 2 2 RNA helicase TIP49 PF06068.13 ORX62658.1 - 9.8e-06 25.0 0.0 0.034 13.4 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_25 PF13481.6 ORX62658.1 - 2.6e-05 23.9 0.8 0.097 12.2 0.0 3.7 3 1 0 4 4 3 1 AAA domain ATPase_2 PF01637.18 ORX62658.1 - 5.4e-05 23.2 0.1 1.2 9.0 0.0 3.2 2 1 0 3 3 3 2 ATPase domain predominantly from Archaea Vps4_C PF09336.10 ORX62658.1 - 7.6e-05 22.6 0.0 0.0085 16.1 0.0 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_7 PF12775.7 ORX62658.1 - 9.6e-05 22.0 0.1 0.14 11.7 0.0 2.8 3 0 0 3 3 3 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 ORX62658.1 - 0.00011 21.7 0.9 0.62 9.4 0.1 3.2 3 0 0 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ORX62658.1 - 0.00017 21.5 0.0 0.42 10.5 0.0 2.9 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ORX62658.1 - 0.00033 20.5 0.0 0.44 10.3 0.0 2.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 ORX62658.1 - 0.00043 20.3 0.0 0.19 11.7 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ORX62658.1 - 0.00058 19.8 0.7 1.2 9.0 0.0 3.3 3 0 0 3 3 3 1 NACHT domain AAA_24 PF13479.6 ORX62658.1 - 0.00077 19.2 0.0 0.051 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 ORX62658.1 - 0.00088 19.2 0.2 1.1 9.2 0.0 2.9 2 2 0 2 2 2 1 NTPase AAA_11 PF13086.6 ORX62658.1 - 0.001 18.9 0.0 0.81 9.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 ORX62658.1 - 0.0011 18.8 0.0 0.028 14.3 0.0 2.9 3 1 0 3 3 3 1 Bacterial dnaA protein IstB_IS21 PF01695.17 ORX62658.1 - 0.0012 18.6 0.1 0.067 12.9 0.0 3.1 3 0 0 3 3 3 1 IstB-like ATP binding protein ABC_tran PF00005.27 ORX62658.1 - 0.0019 18.7 0.0 0.94 10.0 0.0 2.8 2 1 0 2 2 2 1 ABC transporter AAA_17 PF13207.6 ORX62658.1 - 0.0019 18.6 0.9 0.21 12.0 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ORX62658.1 - 0.0026 18.0 0.0 0.52 10.5 0.0 2.8 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ORX62658.1 - 0.0063 15.7 0.0 1.8 7.7 0.0 2.7 3 1 0 3 3 3 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 ORX62658.1 - 0.011 15.4 0.2 2.2 7.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 ORX62658.1 - 0.013 16.1 0.0 0.93 10.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ORX62658.1 - 0.021 14.0 0.1 1.4 8.0 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain AAA_19 PF13245.6 ORX62658.1 - 0.045 14.1 0.1 7.3 6.9 0.0 2.9 2 1 1 3 3 2 0 AAA domain AFG1_ATPase PF03969.16 ORX62658.1 - 0.063 12.2 0.1 2.1 7.2 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase Zeta_toxin PF06414.12 ORX62658.1 - 0.083 12.2 0.1 3.8 6.7 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin SRP54 PF00448.22 ORX62658.1 - 0.092 12.4 0.1 12 5.4 0.0 3.3 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain EGF_3 PF12947.7 ORX62660.1 - 0.056 13.7 2.1 0.056 13.7 2.1 2.6 2 0 0 2 2 2 0 EGF domain Ribosomal_L2 PF00181.23 ORX62661.1 - 0.032 14.2 0.0 0.08 12.9 0.0 1.6 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain Metallophos PF00149.28 ORX62662.1 - 5.9e-16 59.6 5.3 1.7e-15 58.0 5.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ORX62662.1 - 3.9e-09 36.9 0.0 7.9e-09 35.9 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Arrestin_N PF00339.29 ORX62663.1 - 2.3e-08 34.2 0.0 1.5e-07 31.6 0.0 2.1 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 ORX62663.1 - 0.013 15.9 0.0 0.041 14.3 0.0 1.9 1 1 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain Thr_synth_N PF14821.6 ORX62664.1 - 9.6e-29 99.4 0.0 2.3e-28 98.2 0.0 1.7 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 ORX62664.1 - 5.2e-13 49.1 0.0 1.6e-12 47.5 0.0 1.6 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WYL_3 PF18488.1 ORX62664.1 - 0.074 13.4 0.2 19 5.7 0.1 2.4 2 0 0 2 2 2 0 WYL domain ANKH PF07260.11 ORX62664.1 - 0.11 11.7 0.0 0.18 11.0 0.0 1.2 1 0 0 1 1 1 0 Progressive ankylosis protein (ANKH) DUF2797 PF10977.8 ORX62664.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) OCRE PF17780.1 ORX62665.1 - 0.0017 18.3 2.6 0.0056 16.7 2.6 1.9 1 0 0 1 1 1 1 OCRE domain PH_9 PF15410.6 ORX62665.1 - 0.045 14.1 0.0 0.32 11.4 0.0 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain DRIM PF07539.12 ORX62666.1 - 1e-172 575.8 10.0 5.8e-172 573.2 0.3 4.4 4 0 0 4 4 4 2 Down-regulated in metastasis HEAT PF02985.22 ORX62666.1 - 0.00061 19.8 1.1 2 8.9 0.2 5.5 6 0 0 6 6 6 1 HEAT repeat Vac14_Fab1_bd PF12755.7 ORX62666.1 - 0.0044 17.6 4.9 4.6 7.9 0.1 5.9 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ORX62666.1 - 0.035 14.2 3.5 3.7 7.6 0.1 5.0 3 1 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 PTP_tm PF18861.1 ORX62668.1 - 2.2e-06 27.8 0.2 3.7e-05 23.8 0.1 2.1 2 0 0 2 2 2 1 Transmembrane domain of protein tyrosine phosphatase, receptor type J GPI-anchored PF10342.9 ORX62668.1 - 4.2e-05 24.2 0.5 0.00014 22.6 0.4 1.9 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Peptidase_M17 PF00883.21 ORX62669.1 - 8.4e-59 199.4 0.0 1.3e-58 198.7 0.0 1.3 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain GTP_EFTU PF00009.27 ORX62670.1 - 2.1e-20 73.1 0.0 3.7e-20 72.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ORX62670.1 - 1.3e-08 35.1 1.9 3e-08 33.9 1.2 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 ORX62670.1 - 8.6e-05 22.8 0.0 0.00024 21.4 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ORX62670.1 - 0.0018 18.4 0.1 0.0065 16.5 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ORX62670.1 - 0.016 15.0 0.1 2.5 7.9 0.0 3.1 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation CoA_binding_2 PF13380.6 ORX62671.1 - 5.8e-34 117.1 0.0 6.6e-34 116.9 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain Pro-kuma_activ PF09286.11 ORX62671.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.5 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain SpoU_sub_bind PF08032.12 ORX62671.1 - 0.12 12.6 0.0 0.45 10.8 0.0 1.8 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding DUF846 PF05832.12 ORX62672.1 - 4.1e-55 185.6 13.0 5e-55 185.4 13.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) SLC3A2_N PF16028.5 ORX62672.1 - 0.18 11.4 1.7 0.51 9.9 1.7 1.8 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus UPF0014 PF03649.13 ORX62672.1 - 3 7.1 8.3 0.81 9.0 1.6 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0014) RseC_MucC PF04246.12 ORX62672.1 - 3.4 7.6 6.8 13 5.8 1.5 2.2 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF5592 PF17332.2 ORX62672.1 - 9.8 6.8 8.9 3.6 8.2 0.7 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5592) USP7_ICP0_bdg PF12436.8 ORX62673.1 - 2.7e-60 203.7 0.0 1.4e-59 201.3 0.0 2.1 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 ORX62673.1 - 2.6e-55 187.3 3.6 1.8e-53 181.4 0.2 2.7 3 0 0 3 3 3 2 Ubiquitin-specific protease C-terminal UCH PF00443.29 ORX62673.1 - 1.2e-46 159.3 0.2 1.9e-46 158.6 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ORX62673.1 - 5.4e-21 75.5 0.0 1.2e-20 74.3 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 ORX62673.1 - 2.1e-06 27.9 0.0 5.8e-06 26.4 0.0 1.7 1 0 0 1 1 1 1 MATH domain Mcp5_PH PF12814.7 ORX62674.1 - 6.4e-25 87.6 1.1 1.7e-24 86.3 1.1 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Takusan PF04822.13 ORX62674.1 - 1.3 9.0 11.9 7.3 6.5 11.9 2.4 1 1 0 1 1 1 0 Takusan HSP70 PF00012.20 ORX62674.1 - 1.9 6.5 5.6 5 5.2 5.6 1.7 1 0 0 1 1 1 0 Hsp70 protein Ras PF00071.22 ORX62675.1 - 9.4e-63 210.6 0.6 1.2e-62 210.3 0.6 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX62675.1 - 4.2e-35 120.6 0.3 6.3e-35 120.0 0.3 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX62675.1 - 1.3e-14 54.1 0.1 1.7e-14 53.7 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ORX62675.1 - 4.6e-06 26.7 0.1 7.7e-06 26.0 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ORX62675.1 - 0.00016 21.3 0.8 0.0014 18.2 0.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ORX62675.1 - 0.00018 21.8 0.1 0.00088 19.6 0.1 2.0 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 ORX62675.1 - 0.0004 19.9 0.0 0.00062 19.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ORX62675.1 - 0.00066 19.1 0.1 0.00093 18.6 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ORX62675.1 - 0.0007 19.5 0.1 0.48 10.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase DLIC PF05783.11 ORX62675.1 - 0.001 18.0 0.0 0.018 13.9 0.1 2.0 1 1 1 2 2 2 1 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 ORX62675.1 - 0.0058 17.0 0.2 0.011 16.1 0.2 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ORX62675.1 - 0.0076 16.0 0.2 0.017 14.8 0.2 1.8 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ORX62675.1 - 0.011 16.0 0.4 0.085 13.1 0.3 2.3 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ORX62675.1 - 0.015 14.8 0.0 0.04 13.4 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 ORX62675.1 - 0.015 14.7 0.0 0.077 12.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 ORX62675.1 - 0.019 14.7 0.0 0.055 13.2 0.0 1.8 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ORX62675.1 - 0.021 15.3 0.2 0.037 14.6 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 ORX62675.1 - 0.025 14.6 0.1 0.068 13.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain SpoIIID PF12116.8 ORX62675.1 - 0.06 13.4 0.3 1.8 8.7 0.1 2.3 2 0 0 2 2 2 0 Stage III sporulation protein D FeoB_N PF02421.18 ORX62675.1 - 0.071 12.6 0.3 0.22 11.1 0.3 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B Pox_A32 PF04665.12 ORX62675.1 - 0.075 12.5 0.1 0.33 10.4 0.0 1.9 2 1 1 3 3 3 0 Poxvirus A32 protein AAA_5 PF07728.14 ORX62675.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 ORX62675.1 - 0.14 12.1 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_21 PF13304.6 ORX62675.1 - 0.14 11.9 0.6 0.16 11.8 0.6 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system zf-CCCH_2 PF14608.6 ORX62676.1 - 8.8e-07 29.2 15.3 0.00024 21.4 1.3 2.3 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ORX62676.1 - 0.41 10.5 5.5 14 5.6 5.5 2.4 1 1 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ORX62676.1 - 0.69 10.1 5.1 1.1 9.5 0.1 3.0 2 1 1 3 3 3 0 Zinc finger domain Seipin PF06775.14 ORX62677.1 - 3.1e-54 184.1 1.8 4e-54 183.7 1.8 1.1 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Sigma_reg_N PF13800.6 ORX62677.1 - 0.045 14.0 1.5 0.58 10.5 0.0 2.7 2 1 1 3 3 3 0 Sigma factor regulator N-terminal EFG_II PF14492.6 ORX62677.1 - 0.072 13.2 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Elongation Factor G, domain II GGACT PF06094.12 ORX62678.1 - 5.5e-19 68.9 0.1 7e-19 68.6 0.1 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like FUSC_2 PF13515.6 ORX62680.1 - 2.1e-20 73.2 8.7 2.1e-20 73.2 8.7 2.6 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 ORX62680.1 - 7.1e-18 64.5 4.4 1.6e-15 56.7 0.4 3.0 3 0 0 3 3 3 2 Fusaric acid resistance protein family ArAE_2 PF10334.9 ORX62680.1 - 5.6e-11 42.7 0.8 1.2e-10 41.6 0.1 1.9 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ALMT PF11744.8 ORX62680.1 - 2.5e-08 33.2 11.0 3.2e-06 26.3 7.5 2.8 2 1 0 2 2 2 2 Aluminium activated malate transporter ArAE_2_N PF10337.9 ORX62680.1 - 2.9e-06 26.6 0.2 2.9e-06 26.6 0.2 2.0 3 0 0 3 3 3 1 Putative ER transporter, 6TM, N-terminal ArAE_1 PF06081.11 ORX62680.1 - 0.12 12.6 3.1 0.31 11.2 2.5 2.0 1 1 0 1 1 1 0 Aromatic acid exporter family member 1 SHR3_chaperone PF08229.11 ORX62681.1 - 5.5e-41 139.6 0.8 6.3e-41 139.4 0.8 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF4383 PF14325.6 ORX62681.1 - 0.045 14.0 1.2 0.082 13.2 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4383) ATP-synt_D PF01813.17 ORX62682.1 - 0.031 14.1 0.3 0.044 13.6 0.3 1.2 1 0 0 1 1 1 0 ATP synthase subunit D HABP4_PAI-RBP1 PF04774.15 ORX62683.1 - 1e-05 26.3 0.7 1.2e-05 26.1 0.7 1.1 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family Aa_trans PF01490.18 ORX62684.1 - 3.5e-75 253.3 30.3 4e-75 253.0 30.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NDUF_B12 PF08122.12 ORX62684.1 - 0.0018 18.2 0.6 2.1 8.5 0.0 3.5 3 0 0 3 3 3 2 NADH-ubiquinone oxidoreductase B12 subunit family TIM21 PF08294.11 ORX62684.1 - 0.079 12.8 0.4 1.9 8.4 0.0 2.6 2 0 0 2 2 2 0 TIM21 DUF1724 PF08350.10 ORX62684.1 - 0.12 12.5 0.1 0.46 10.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1724) TMIE PF16038.5 ORX62684.1 - 6.4 6.7 5.4 0.6 10.0 0.1 2.0 2 0 0 2 2 2 0 TMIE protein UPF0020 PF01170.18 ORX62685.1 - 9.6e-24 84.2 0.0 9.2e-22 77.7 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 ORX62685.1 - 5.1e-08 33.5 0.0 2.7e-07 31.2 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX62685.1 - 3.3e-06 27.7 0.0 9.3e-06 26.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX62685.1 - 0.00014 21.4 0.0 0.0082 15.6 0.0 2.2 2 0 0 2 2 2 1 Putative methyltransferase Ubie_methyltran PF01209.18 ORX62685.1 - 0.00033 20.1 0.0 0.00098 18.5 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ORX62685.1 - 0.0004 20.0 0.0 0.0013 18.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ORX62685.1 - 0.01 15.6 0.0 0.027 14.3 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 ORX62685.1 - 0.017 14.5 0.0 0.74 9.1 0.0 2.8 2 1 0 2 2 2 0 Mycolic acid cyclopropane synthetase N6_Mtase PF02384.16 ORX62685.1 - 0.039 13.2 0.0 0.075 12.3 0.0 1.4 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_18 PF12847.7 ORX62685.1 - 0.056 13.4 0.0 0.093 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain NDK PF00334.19 ORX62685.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 Nucleoside diphosphate kinase HLH PF00010.26 ORX62686.1 - 7.8e-18 64.2 3.2 2.1e-17 62.8 3.2 1.8 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Peptidase_S64 PF08192.11 ORX62686.1 - 0.059 11.9 0.2 0.082 11.4 0.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4200 PF13863.6 ORX62686.1 - 0.16 12.4 2.5 0.28 11.6 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CH PF00307.31 ORX62687.1 - 2.2e-24 85.7 0.0 3.1e-24 85.3 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Calponin PF00402.18 ORX62687.1 - 1.6e-09 37.3 1.5 2.7e-09 36.5 1.5 1.4 1 0 0 1 1 1 1 Calponin family repeat CAMSAP_CH PF11971.8 ORX62687.1 - 0.0013 18.5 0.0 0.0025 17.6 0.0 1.6 1 1 0 1 1 1 1 CAMSAP CH domain ELFV_dehydrog PF00208.21 ORX62688.1 - 2.6e-57 194.3 0.0 4.8e-57 193.5 0.0 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 ORX62688.1 - 1.8e-26 92.1 0.0 2.2e-17 62.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 ORX62688.1 - 0.043 13.7 0.0 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain OSCP PF00213.18 ORX62690.1 - 1.7e-44 151.9 6.2 2.4e-44 151.5 6.2 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit DUF1539 PF07560.11 ORX62690.1 - 0.017 15.2 1.8 3.2 7.8 0.3 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) Spb1_C PF07780.12 ORX62690.1 - 0.019 14.6 1.6 0.51 9.9 0.2 2.2 2 0 0 2 2 2 0 Spb1 C-terminal domain SPOUT_MTase PF02590.17 ORX62690.1 - 0.029 14.3 0.5 0.043 13.8 0.5 1.2 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase polyprenyl_synt PF00348.17 ORX62691.1 - 2.1e-94 315.4 0.1 2.8e-94 315.0 0.1 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase IP_trans PF02121.18 ORX62693.1 - 4.3e-108 360.6 0.6 4.9e-108 360.4 0.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol transfer protein Glu-tRNAGln PF02686.15 ORX62694.1 - 3.9e-08 33.5 0.0 5.3e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit Tom37 PF10568.9 ORX62695.1 - 1.9e-23 83.1 0.1 3.4e-23 82.3 0.1 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_6 PF17171.4 ORX62695.1 - 2.4e-18 65.7 0.0 5.2e-18 64.6 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 ORX62695.1 - 3.9e-12 46.8 0.0 8.6e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 ORX62695.1 - 8.6e-08 32.1 0.1 7.5e-07 29.1 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX62695.1 - 0.00059 20.0 0.0 0.0015 18.7 0.0 1.6 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX62695.1 - 0.049 13.8 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UQ_con PF00179.26 ORX62696.1 - 1.9e-50 170.1 0.0 2.2e-50 170.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme GAT PF03127.14 ORX62696.1 - 0.16 12.3 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 GAT domain Sin3a_C PF16879.5 ORX62697.1 - 1.9e-52 178.8 3.2 1.9e-52 178.8 3.2 2.7 3 0 0 3 3 3 1 C-terminal domain of Sin3a protein PAH PF02671.21 ORX62697.1 - 3.7e-45 151.8 8.0 5.4e-18 64.9 0.0 4.2 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 ORX62697.1 - 1.5e-38 130.8 0.2 3.9e-38 129.5 0.1 1.8 2 0 0 2 2 1 1 Sin3 family co-repressor PGA2 PF07543.12 ORX62697.1 - 0.048 13.6 6.0 0.12 12.4 6.0 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 ORX62697.1 - 0.25 9.6 6.9 0.41 8.9 6.9 1.2 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ORX62697.1 - 0.43 10.6 5.7 0.44 10.6 2.8 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.6 ORX62697.1 - 2.3 7.9 6.6 6.7 6.4 6.6 1.7 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 ORX62697.1 - 2.4 7.5 12.8 0.32 10.4 6.5 2.2 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ORX62697.1 - 2.5 6.2 16.2 4.4 5.4 13.2 2.3 2 0 0 2 2 2 0 Nop14-like family DNA_pol_phi PF04931.13 ORX62697.1 - 5.7 4.9 13.7 9.7 4.2 13.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 ORX62697.1 - 7 6.7 16.0 0.29 11.2 9.3 2.0 2 0 0 2 2 2 0 YL1 nuclear protein DUF2052 PF09747.9 ORX62697.1 - 8.3 6.5 16.8 0.67 10.0 6.2 3.6 4 1 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) MFS_1 PF07690.16 ORX62698.1 - 1.6e-21 76.6 57.5 2.3e-12 46.5 15.0 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX62698.1 - 1.3e-05 24.0 14.9 1.3e-05 24.0 14.9 2.4 1 1 2 3 3 3 1 MFS/sugar transport protein Granulin PF00396.18 ORX62700.1 - 0.037 14.4 20.9 0.037 14.4 20.9 2.9 2 1 1 3 3 3 0 Granulin Granulin PF00396.18 ORX62701.1 - 6 7.3 24.1 0.34 11.3 3.8 2.5 1 1 1 2 2 2 0 Granulin GTP_EFTU PF00009.27 ORX62702.1 - 2.3e-35 121.9 0.0 1.7e-34 119.1 0.0 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ORX62702.1 - 9.4e-18 64.3 0.0 3.1e-17 62.6 0.0 1.9 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 ORX62702.1 - 7.7e-15 55.0 3.9 1.4e-09 38.2 0.0 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ORX62702.1 - 7.7e-12 45.0 0.9 2.1e-11 43.6 0.9 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 ORX62702.1 - 3.4e-06 27.1 0.1 2e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 ORX62702.1 - 0.0012 19.1 0.0 0.0028 17.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 ORX62702.1 - 0.012 15.4 0.0 0.033 13.9 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein PUA PF01472.20 ORX62702.1 - 0.019 14.9 0.0 3 7.9 0.1 2.8 2 0 0 2 2 2 0 PUA domain RsgA_GTPase PF03193.16 ORX62702.1 - 0.058 13.3 0.4 0.71 9.7 0.2 2.8 2 1 0 2 2 2 0 RsgA GTPase HLH PF00010.26 ORX62703.1 - 1e-12 47.8 1.5 1.9e-12 47.0 1.5 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain zf-C2H2 PF00096.26 ORX62704.1 - 2.4e-10 40.3 11.8 3e-06 27.4 1.9 3.0 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX62704.1 - 0.00017 22.1 18.1 0.0052 17.5 2.1 3.5 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX62704.1 - 0.0025 18.2 22.3 0.6 10.6 12.7 4.3 3 1 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 ORX62704.1 - 0.019 15.4 5.4 2.2 8.8 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type DUF629 PF04780.12 ORX62704.1 - 0.02 13.5 0.0 0.02 13.5 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF629) zf-C2H2_jaz PF12171.8 ORX62704.1 - 0.055 13.8 0.6 0.055 13.8 0.6 3.0 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 ORX62704.1 - 0.13 12.9 3.3 1.3 9.7 0.2 2.4 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 ORX62704.1 - 4.1 7.3 16.6 0.98 9.2 0.8 3.4 3 1 0 3 3 3 0 C2H2-type zinc-finger domain Dopey_N PF04118.14 ORX62705.1 - 1.1e-106 356.4 0.8 1e-105 353.3 0.0 2.7 2 0 0 2 2 2 1 Dopey, N-terminal DCB PF16213.5 ORX62705.1 - 0.013 15.1 0.1 0.037 13.7 0.1 1.7 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 PEN-2 PF10251.9 ORX62706.1 - 3.9e-29 100.9 2.8 4.4e-29 100.8 2.8 1.0 1 0 0 1 1 1 1 Presenilin enhancer-2 subunit of gamma secretase HisKA_7TM PF16927.5 ORX62706.1 - 0.0063 16.6 1.7 0.0072 16.4 1.7 1.1 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase DUF2530 PF10745.9 ORX62706.1 - 0.12 12.6 0.6 0.25 11.6 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2530) TauD PF02668.16 ORX62707.1 - 1.3e-43 149.7 1.5 2.8e-43 148.7 1.5 1.5 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Glyco_hydro_18 PF00704.28 ORX62708.1 - 6.5e-21 75.4 0.4 3e-20 73.2 0.4 1.8 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 MFS_1 PF07690.16 ORX62709.1 - 1.5e-37 129.4 30.1 3.7e-37 128.1 30.4 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily TMEM237 PF15383.6 ORX62709.1 - 0.039 13.1 0.0 0.73 8.9 0.0 2.3 2 0 0 2 2 2 0 Transmembrane protein 237 Phage_holin_5_1 PF06946.11 ORX62709.1 - 0.17 12.3 0.1 0.17 12.3 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage A118-like holin, Hol118 Pkinase PF00069.25 ORX62710.1 - 1.6e-74 250.6 0.0 2.3e-74 250.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62710.1 - 2.7e-36 125.2 0.0 3.8e-36 124.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62710.1 - 6.8e-05 22.3 0.0 0.00015 21.2 0.0 1.7 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ORX62710.1 - 0.096 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Zip PF02535.22 ORX62710.1 - 9.3 5.4 5.6 12 5.0 5.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Mito_carr PF00153.27 ORX62711.1 - 2.6e-67 222.8 2.8 2e-21 75.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX62711.1 - 0.0021 17.2 4.3 0.19 10.8 0.4 3.3 2 1 1 4 4 4 2 Gammaproteobacterial serine protease FAD_binding_3 PF01494.19 ORX62712.1 - 3.5e-26 92.3 0.0 5.8e-12 45.5 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 ORX62712.1 - 1.6e-05 24.2 0.0 0.0065 15.6 0.0 2.9 3 0 0 3 3 3 2 Lycopene cyclase protein DAO PF01266.24 ORX62712.1 - 8.3e-05 22.3 0.0 0.00036 20.2 0.1 1.9 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ORX62712.1 - 0.00054 19.3 0.0 0.00095 18.5 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 ORX62712.1 - 0.001 18.2 0.0 0.0016 17.5 0.0 1.3 1 0 0 1 1 1 1 Squalene epoxidase Trp_halogenase PF04820.14 ORX62712.1 - 0.01 14.7 0.1 0.095 11.5 0.1 2.4 3 0 0 3 3 3 0 Tryptophan halogenase NAD_binding_9 PF13454.6 ORX62712.1 - 0.023 14.7 0.0 0.054 13.5 0.0 1.7 1 0 0 1 1 1 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 ORX62712.1 - 0.028 14.6 0.1 0.085 13.1 0.1 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX62712.1 - 0.061 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Thi4 family FAD_binding_2 PF00890.24 ORX62712.1 - 0.065 12.3 0.3 0.18 10.8 0.1 1.8 2 0 0 2 2 2 0 FAD binding domain IMS PF00817.20 ORX62713.1 - 3.2e-47 160.3 0.0 2.3e-46 157.5 0.0 2.2 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 ORX62713.1 - 7.5e-11 42.8 0.2 4.4e-10 40.3 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ORX62713.1 - 0.0081 16.4 0.0 0.021 15.1 0.0 1.8 1 0 0 1 1 1 1 IMS family HHH motif Sgf11 PF08209.11 ORX62713.1 - 0.014 15.0 0.5 0.035 13.7 0.5 1.7 1 1 0 1 1 1 0 Sgf11 (transcriptional regulation protein) CelTOS PF18659.1 ORX62713.1 - 0.015 15.7 0.1 0.046 14.1 0.1 1.8 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites SKI PF01202.22 ORX62714.1 - 4.4e-10 39.9 0.0 1.3e-09 38.4 0.0 1.6 1 1 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 ORX62714.1 - 5.5e-07 29.9 0.0 2.7e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ORX62714.1 - 2.1e-05 25.1 0.0 4.3e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ORX62714.1 - 8.8e-05 23.0 0.0 0.00015 22.2 0.0 1.4 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 ORX62714.1 - 0.00019 21.4 0.0 0.15 11.9 0.0 2.1 1 1 1 2 2 2 2 Deoxynucleoside kinase Cytidylate_kin PF02224.18 ORX62714.1 - 0.00089 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase Zeta_toxin PF06414.12 ORX62714.1 - 0.0015 17.9 0.1 0.0022 17.3 0.1 1.4 1 1 0 1 1 1 1 Zeta toxin APS_kinase PF01583.20 ORX62714.1 - 0.0018 18.2 0.0 0.0023 17.8 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.6 ORX62714.1 - 0.0036 17.6 0.1 0.041 14.2 0.1 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX62714.1 - 0.019 15.4 0.0 0.031 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ORX62714.1 - 0.021 15.3 0.1 0.043 14.2 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ORX62714.1 - 0.059 13.3 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain PRK PF00485.18 ORX62714.1 - 0.097 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Herpes_Helicase PF02689.14 ORX62714.1 - 0.097 10.6 0.0 0.12 10.2 0.0 1.1 1 0 0 1 1 1 0 Helicase Thymidylate_kin PF02223.17 ORX62714.1 - 0.13 12.0 0.0 4.8 6.8 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase CoaE PF01121.20 ORX62714.1 - 0.14 11.9 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Dephospho-CoA kinase Viral_helicase1 PF01443.18 ORX62714.1 - 0.15 11.7 0.0 0.26 11.0 0.0 1.5 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF745 PF05335.13 ORX62715.1 - 0.018 14.8 4.4 0.018 14.8 4.4 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF745) Jnk-SapK_ap_N PF09744.9 ORX62715.1 - 0.085 13.1 19.1 0.98 9.6 5.1 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 LIM PF00412.22 ORX62715.1 - 0.1 12.9 0.6 0.1 12.9 0.6 1.9 2 0 0 2 2 1 0 LIM domain Carbam_trans_N PF02543.15 ORX62715.1 - 0.11 12.1 2.6 0.15 11.7 2.6 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus Spc7 PF08317.11 ORX62715.1 - 0.2 10.5 14.2 0.53 9.1 2.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 ORX62715.1 - 0.29 10.9 5.4 0.73 9.6 4.9 2.0 1 1 0 1 1 1 0 Phage minor structural protein GP20 DUF1664 PF07889.12 ORX62715.1 - 0.3 11.1 4.1 1.7 8.7 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 ORX62715.1 - 0.35 11.6 11.7 1.5 9.6 2.3 2.9 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4201 PF13870.6 ORX62715.1 - 0.35 10.6 17.4 0.078 12.7 12.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Fib_alpha PF08702.10 ORX62715.1 - 0.42 10.8 13.3 3.4 7.9 0.2 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Uso1_p115_C PF04871.13 ORX62715.1 - 0.8 10.1 13.3 0.5 10.7 9.7 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Snapin_Pallidin PF14712.6 ORX62715.1 - 1.2 9.6 17.2 1.2 9.7 2.1 3.6 2 1 1 3 3 3 0 Snapin/Pallidin APG6_N PF17675.1 ORX62715.1 - 1.2 9.7 20.7 0.28 11.7 5.3 3.2 2 1 0 2 2 2 0 Apg6 coiled-coil region Lebercilin PF15619.6 ORX62715.1 - 2.2 7.9 19.5 0.075 12.7 5.3 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CREPT PF16566.5 ORX62715.1 - 3.3 7.9 14.6 0.33 11.1 2.0 3.2 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Occludin_ELL PF07303.13 ORX62715.1 - 5.9 7.7 20.6 1.7 9.4 2.9 4.0 2 2 1 3 3 3 0 Occludin homology domain zf-CCCH_2 PF14608.6 ORX62716.1 - 8.5e-07 29.2 22.7 0.00043 20.6 5.8 2.3 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ORX62716.1 - 0.26 11.1 16.0 0.26 11.1 12.6 2.8 1 1 1 2 2 2 0 CCCH-type zinc finger Ribosom_S12_S23 PF00164.25 ORX62717.1 - 5.4e-52 174.2 0.8 6.8e-52 173.9 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DnaJ_C PF01556.18 ORX62718.1 - 4e-31 108.1 0.0 5.6e-31 107.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ORX62718.1 - 1.9e-13 50.3 0.1 3.6e-13 49.4 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain RasGEF PF00617.19 ORX62719.1 - 4.4e-52 176.8 0.1 1.3e-51 175.4 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ORX62719.1 - 4.3e-19 68.7 0.2 2.8e-18 66.1 0.1 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_2 PF07653.17 ORX62719.1 - 6.9e-08 32.1 0.0 1.4e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ORX62719.1 - 3.3e-07 29.8 0.0 6.3e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ORX62719.1 - 2.6e-06 27.2 0.2 5.1e-06 26.3 0.2 1.5 1 0 0 1 1 1 1 Variant SH3 domain MCM PF00493.23 ORX62720.1 - 2.6e-103 344.0 0.0 4.1e-103 343.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ORX62720.1 - 3.9e-32 110.8 0.5 8.2e-32 109.7 0.5 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ORX62720.1 - 1.4e-18 67.1 2.8 3.7e-18 65.7 2.8 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ORX62720.1 - 9.8e-13 48.6 0.5 2.4e-12 47.4 0.5 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 ORX62720.1 - 2.4e-07 30.3 0.0 7.1e-06 25.6 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ORX62720.1 - 4.2e-06 26.8 0.0 1.5e-05 25.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase_C PF13335.6 ORX62720.1 - 0.00068 20.2 1.4 0.0022 18.6 0.7 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI C-terminal AAA_lid_2 PF17863.1 ORX62720.1 - 0.0062 16.3 0.3 0.017 15.0 0.3 1.7 1 0 0 1 1 1 1 AAA lid domain AAA_3 PF07726.11 ORX62720.1 - 0.013 15.4 0.0 0.049 13.5 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ORX62720.1 - 0.029 14.1 0.0 0.4 10.4 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain Imm63 PF15599.6 ORX62720.1 - 0.14 12.5 0.0 0.58 10.6 0.0 2.0 1 0 0 1 1 1 0 Immunity protein 63 DUF2489 PF10675.9 ORX62720.1 - 0.44 10.5 4.3 0.081 12.8 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Zn-ribbon_8 PF09723.10 ORX62720.1 - 0.74 10.0 2.4 2 8.6 2.4 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Abhydrolase_1 PF00561.20 ORX62721.1 - 1.7e-16 60.6 0.3 6.4e-15 55.5 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ORX62721.1 - 2.6e-08 33.5 0.0 7.9e-08 31.9 0.0 1.7 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX62721.1 - 2e-05 25.3 0.0 3.4e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF3089 PF11288.8 ORX62721.1 - 0.00013 21.6 0.0 0.00035 20.2 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3089) Peptidase_S15 PF02129.18 ORX62721.1 - 0.00014 21.6 0.0 0.0002 21.0 0.0 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Palm_thioest PF02089.15 ORX62721.1 - 0.0022 17.9 0.0 0.0032 17.4 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF915 PF06028.11 ORX62721.1 - 0.18 11.1 0.0 0.43 9.9 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF915) OPT PF03169.15 ORX62722.1 - 1.1e-175 585.8 45.1 1.3e-175 585.6 45.1 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein LAG1-DNAbind PF09271.11 ORX62723.1 - 1.4e-24 87.4 1.8 1.3e-21 77.8 0.5 3.0 2 1 0 2 2 2 1 LAG1, DNA binding BTD PF09270.10 ORX62723.1 - 1.8e-19 70.5 0.0 1.5e-18 67.5 0.0 2.1 2 0 0 2 2 2 1 Beta-trefoil DNA-binding domain CAF1-p150_C2 PF15539.6 ORX62723.1 - 0.036 13.5 1.4 0.066 12.7 1.4 1.3 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term TMEM132D_N PF15705.5 ORX62723.1 - 0.076 12.9 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, N-term PH_9 PF15410.6 ORX62724.1 - 8.7e-08 32.5 0.1 4.7e-07 30.2 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain Sec7 PF01369.20 ORX62724.1 - 0.00019 21.2 0.0 0.0005 19.8 0.0 1.6 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 ORX62724.1 - 0.0018 18.7 0.0 0.0051 17.3 0.0 1.7 1 0 0 1 1 1 1 PH domain NRDD PF13597.6 ORX62724.1 - 0.078 11.7 0.4 0.29 9.8 0.0 1.8 2 0 0 2 2 2 0 Anaerobic ribonucleoside-triphosphate reductase NUC194 PF08163.12 ORX62724.1 - 0.33 9.9 2.7 0.25 10.3 0.2 1.8 2 0 0 2 2 2 0 NUC194 domain DUF2887 PF11103.8 ORX62725.1 - 0.065 13.2 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2887) Trypan_PARP PF05887.11 ORX62725.1 - 0.57 10.2 38.9 26 4.8 7.1 3.2 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) HTH_42 PF06224.12 ORX62726.1 - 0.031 13.8 0.1 0.051 13.1 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain ApoO PF09769.9 ORX62727.1 - 6.9e-29 100.4 0.2 3.4e-26 91.7 0.0 2.3 2 0 0 2 2 2 2 Apolipoprotein O Baculo_PEP_C PF04513.12 ORX62727.1 - 0.00068 19.7 0.0 0.93 9.5 0.0 2.2 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 ORX62727.1 - 0.012 15.2 0.6 0.047 13.3 0.3 1.9 1 1 1 2 2 2 0 PspA/IM30 family WXG100 PF06013.12 ORX62727.1 - 0.015 15.5 0.3 0.83 9.9 0.1 2.3 2 0 0 2 2 2 0 Proteins of 100 residues with WXG HisKA_3 PF07730.13 ORX62727.1 - 0.016 15.7 0.2 6.7 7.3 0.0 3.0 2 2 0 2 2 2 0 Histidine kinase LPP PF04728.13 ORX62727.1 - 0.016 15.6 0.8 5.2 7.5 0.1 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper ApoLp-III PF07464.11 ORX62727.1 - 0.019 15.1 2.4 1.4 9.0 0.8 2.9 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Apolipoprotein PF01442.18 ORX62727.1 - 0.02 14.7 0.8 2.1 8.2 0.2 2.3 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Prominin PF05478.11 ORX62727.1 - 0.051 11.5 0.8 0.2 9.6 0.2 1.8 1 1 1 2 2 2 0 Prominin Fib_alpha PF08702.10 ORX62727.1 - 0.08 13.1 0.9 2.2 8.5 0.3 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FUSC-like PF12805.7 ORX62727.1 - 0.094 11.8 0.1 0.13 11.3 0.1 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Halogen_Hydrol PF10112.9 ORX62727.1 - 0.094 12.7 0.1 1.3 9.0 0.2 2.2 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF2884 PF11101.8 ORX62727.1 - 0.14 11.6 2.7 0.18 11.3 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2884) DUF883 PF05957.13 ORX62727.1 - 0.17 12.5 5.4 2.8 8.6 0.3 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 ORX62727.1 - 0.19 12.3 1.9 2.6 8.6 0.8 3.0 2 1 0 2 2 2 0 YtxH-like protein DUF4448 PF14610.6 ORX62728.1 - 0.00073 19.4 0.1 0.0012 18.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Insulin_TMD PF17870.1 ORX62728.1 - 0.015 15.3 0.3 0.039 14.0 0.3 1.7 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Calcipressin PF04847.12 ORX62729.1 - 7.4e-26 91.0 0.6 1.8e-25 89.8 0.6 1.8 1 1 0 1 1 1 1 Calcipressin TPR_2 PF07719.17 ORX62730.1 - 1.1e-11 43.9 10.9 0.0057 16.7 0.1 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ORX62730.1 - 5.3e-10 38.7 10.1 0.072 12.9 0.1 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62730.1 - 6.8e-10 39.1 15.8 0.0022 18.2 5.0 5.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62730.1 - 7.7e-09 35.1 5.5 0.015 15.5 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62730.1 - 1.9e-06 27.5 9.1 0.066 13.3 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ORX62730.1 - 1.3e-05 24.9 12.4 0.00044 20.0 0.6 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62730.1 - 1.6e-05 25.3 8.8 0.03 14.8 2.0 4.1 3 3 0 3 3 3 2 Tetratricopeptide repeat TPR_4 PF07721.14 ORX62730.1 - 0.0053 17.3 0.2 1.6 9.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62730.1 - 0.0058 16.8 4.4 0.62 10.3 1.1 3.9 3 3 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ORX62730.1 - 0.024 15.3 10.1 0.71 10.6 0.2 4.6 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ORX62730.1 - 0.11 12.6 3.0 21 5.3 0.2 3.8 4 1 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ORX62730.1 - 0.12 13.0 0.6 96 4.0 0.3 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62730.1 - 0.24 11.1 3.9 6.1 6.6 0.1 3.5 3 0 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 ORX62730.1 - 0.26 11.7 1.7 23 5.6 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62730.1 - 0.75 10.8 13.9 28 5.9 0.0 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Sel1 PF08238.12 ORX62730.1 - 4 8.2 8.8 40 5.1 0.4 4.7 4 1 0 4 4 4 0 Sel1 repeat Homeodomain PF00046.29 ORX62731.1 - 6.8e-20 70.7 1.1 1.6e-19 69.5 1.1 1.7 1 0 0 1 1 1 1 Homeodomain CrtC PF07143.11 ORX62731.1 - 0.18 12.5 3.7 0.4 11.3 3.7 1.6 1 0 0 1 1 1 0 CrtC N-terminal lipocalin domain PH PF00169.29 ORX62732.1 - 1.1e-08 35.6 0.0 1.8e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 PH domain Clathrin PF00637.20 ORX62733.1 - 1.8e-187 614.7 45.6 1.8e-33 115.4 0.5 8.8 7 2 2 9 9 9 8 Region in Clathrin and VPS Clathrin_propel PF01394.20 ORX62733.1 - 3.6e-37 124.9 0.0 7.5e-07 29.2 0.0 6.6 6 0 0 6 6 6 6 Clathrin propeller repeat Clathrin_H_link PF13838.6 ORX62733.1 - 3.7e-34 116.4 0.7 3.2e-33 113.4 0.0 3.2 3 0 0 3 3 3 1 Clathrin-H-link Clathrin-link PF09268.10 ORX62733.1 - 8e-09 34.7 1.4 8e-09 34.7 1.4 2.0 2 0 0 2 2 2 1 Clathrin, heavy-chain linker Coatomer_WDAD PF04053.14 ORX62733.1 - 3.7e-07 29.6 7.2 0.0012 17.9 0.2 4.2 4 0 0 4 4 4 2 Coatomer WD associated region TPR_1 PF00515.28 ORX62733.1 - 0.00043 20.0 3.2 15 5.6 0.1 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62733.1 - 0.062 14.2 11.4 48 5.2 0.1 8.3 10 0 0 10 10 10 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62733.1 - 0.16 12.2 8.2 24 5.4 0.0 5.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62733.1 - 0.33 11.1 12.9 4.5 7.5 0.1 6.2 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62733.1 - 0.62 10.4 3.7 18 5.8 0.0 4.9 4 0 0 4 4 4 0 Tetratricopeptide repeat FHA PF00498.26 ORX62734.1 - 9.5e-10 38.7 0.1 1.6e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ORX62734.1 - 0.00062 20.0 0.0 0.0011 19.2 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 ORX62734.1 - 0.014 15.6 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 FHA domain Stork_head PF10264.9 ORX62734.1 - 0.15 12.2 0.4 0.31 11.2 0.4 1.4 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain DUF5538 PF17692.1 ORX62734.1 - 0.29 11.2 4.8 0.066 13.3 1.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5538) RT_RNaseH PF17917.1 ORX62735.1 - 4.6e-08 33.3 0.0 8e-08 32.5 0.0 1.3 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 ORX62735.1 - 1e-07 31.9 0.0 1.5e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Glyco_transf_20 PF00982.21 ORX62736.1 - 3.3e-159 530.6 0.1 4.7e-159 530.1 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ORX62736.1 - 2.7e-74 249.2 0.0 5.4e-74 248.2 0.0 1.4 1 0 0 1 1 1 1 Trehalose-phosphatase Ncstrn_small PF18266.1 ORX62736.1 - 8.1e-39 133.3 0.0 3.5e-38 131.3 0.1 2.1 2 0 0 2 2 2 1 Nicastrin small lobe Nicastrin PF05450.15 ORX62736.1 - 7.3e-30 104.2 0.1 3.3e-29 102.0 0.1 2.0 1 1 0 1 1 1 1 Nicastrin Hydrolase_3 PF08282.12 ORX62736.1 - 2e-05 24.5 0.0 0.0055 16.5 0.3 2.4 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase SWIM PF04434.17 ORX62737.1 - 0.15 11.7 0.4 0.25 11.0 0.4 1.3 1 0 0 1 1 1 0 SWIM zinc finger XG_FTase PF03254.13 ORX62738.1 - 0.12 11.0 0.2 0.12 10.9 0.2 1.0 1 0 0 1 1 1 0 Xyloglucan fucosyltransferase Acyl-CoA_dh_1 PF00441.24 ORX62739.1 - 4.7e-45 153.5 4.7 7.3e-45 152.8 4.7 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ORX62739.1 - 2.1e-25 89.6 0.1 7.9e-25 87.7 0.0 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ORX62739.1 - 1.6e-22 79.5 0.1 4.3e-22 78.1 0.0 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ORX62739.1 - 4.2e-21 75.6 0.6 4.2e-21 75.6 0.6 1.7 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, C-terminal domain SpoU_methylase PF00588.19 ORX62740.1 - 1.8e-25 89.7 0.0 5.7e-25 88.1 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family Phage_TAC_3 PF06896.11 ORX62740.1 - 1.1 9.9 4.1 5.5 7.6 0.4 3.5 3 1 1 4 4 4 0 Phage tail assembly chaperone proteins, TAC Kinesin PF00225.23 ORX62741.1 - 2e-90 303.1 0.0 5.8e-90 301.6 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ORX62741.1 - 4.2e-19 68.9 0.6 6.7e-17 61.8 0.0 2.9 3 0 0 3 3 3 1 Microtubule binding SLM4 PF16818.5 ORX62741.1 - 0.13 12.2 1.0 0.33 10.9 1.0 1.8 1 0 0 1 1 1 0 Protein SLM4 DUF4164 PF13747.6 ORX62741.1 - 0.17 12.1 2.7 1.2 9.4 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Streptin-Immun PF11083.8 ORX62741.1 - 0.18 12.2 4.0 5.8 7.4 0.1 3.5 3 1 0 4 4 4 0 Lantibiotic streptin immunity protein Fra10Ac1 PF09725.9 ORX62742.1 - 9.5e-51 171.1 1.2 2e-50 170.1 1.2 1.5 1 0 0 1 1 1 1 Folate-sensitive fragile site protein Fra10Ac1 FYDLN_acid PF09538.10 ORX62742.1 - 0.86 10.3 12.6 0.75 10.5 8.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 ORX62742.1 - 0.89 10.0 4.3 63 4.0 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF5571 PF17732.1 ORX62742.1 - 1.1 8.6 13.3 0.13 11.7 5.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5571) DTHCT PF08070.11 ORX62742.1 - 2 9.2 20.7 0.33 11.7 14.2 2.2 2 0 0 2 2 2 0 DTHCT (NUC029) region Med4 PF10018.9 ORX62743.1 - 3.8e-11 43.0 0.8 5.5e-11 42.5 0.8 1.1 1 0 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 GPI-anchored PF10342.9 ORX62744.1 - 3.6e-11 43.7 3.2 3.6e-11 43.7 3.2 1.7 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Glucan_synthase PF02364.15 ORX62745.1 - 0 1067.3 0.0 0 1067.3 0.0 1.8 2 0 0 2 2 2 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 ORX62745.1 - 3.8e-33 114.6 1.7 1.5e-31 109.4 1.7 2.7 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 RicinB_lectin_2 PF14200.6 ORX62746.1 - 7.8e-17 61.8 2.5 1.8e-07 31.8 0.1 2.6 1 1 2 3 3 3 3 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ORX62746.1 - 1.2e-14 54.7 0.0 5.1e-09 36.5 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain NCU-G1 PF15065.6 ORX62747.1 - 5.2e-08 32.3 2.7 8e-08 31.7 2.7 1.3 1 0 0 1 1 1 1 Lysosomal transcription factor, NCU-G1 RicinB_lectin_2 PF14200.6 ORX62748.1 - 6.9e-14 52.3 0.2 3.1e-08 34.2 0.0 2.4 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ORX62748.1 - 6.1e-13 49.1 0.9 5.1e-08 33.2 0.3 2.0 1 1 0 2 2 2 2 Ricin-type beta-trefoil lectin domain KilA-N PF04383.13 ORX62750.1 - 0.00042 20.1 0.0 0.0011 18.7 0.0 1.8 1 1 0 1 1 1 1 KilA-N domain DUF4881 PF16222.5 ORX62750.1 - 0.083 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4881) PEPCK_ATP PF01293.20 ORX62751.1 - 5.7e-219 727.5 0.0 6.7e-219 727.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 ORX62751.1 - 0.18 12.2 0.0 0.32 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain EF-hand_1 PF00036.32 ORX62752.1 - 3e-18 64.0 5.4 4.7e-07 28.9 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ORX62752.1 - 4.8e-18 65.4 2.2 2e-13 50.6 1.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX62752.1 - 3.9e-13 48.2 6.6 3.3e-05 23.5 0.4 3.9 2 2 3 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 ORX62752.1 - 1.2e-12 47.5 13.4 2e-08 34.0 1.7 2.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ORX62752.1 - 8.3e-11 40.9 11.6 3.2e-05 23.2 0.1 4.3 5 0 0 5 5 5 2 EF hand EF-hand_9 PF14658.6 ORX62752.1 - 1.5e-08 34.8 0.5 0.00042 20.6 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ORX62752.1 - 1.9e-07 31.0 1.2 0.014 15.3 1.0 2.8 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ORX62752.1 - 4.8e-06 26.7 0.8 0.0003 20.9 0.1 1.8 1 1 1 2 2 2 2 Dockerin type I domain SurA_N_3 PF13624.6 ORX62752.1 - 0.0065 16.3 0.3 0.082 12.7 0.1 2.1 1 1 1 2 2 2 1 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 ORX62752.1 - 0.019 15.2 0.3 0.039 14.3 0.3 1.6 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region SAPIS-gp6 PF16722.5 ORX62752.1 - 0.038 14.4 0.1 0.065 13.7 0.1 1.4 1 0 0 1 1 1 0 Pathogenicity island protein gp6 in Staphylococcus Cation_ATPase_N PF00690.26 ORX62752.1 - 0.052 13.2 0.1 0.38 10.5 0.0 2.2 2 0 0 2 2 2 0 Cation transporter/ATPase, N-terminus FlgD PF03963.14 ORX62752.1 - 0.054 13.8 0.9 0.16 12.3 0.2 2.1 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region Ku_PK_bind PF08785.11 ORX62752.1 - 0.061 13.5 0.1 0.099 12.8 0.1 1.4 1 0 0 1 1 1 0 Ku C terminal domain like EF-hand_11 PF08976.11 ORX62752.1 - 0.075 13.9 0.1 9.2 7.2 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Erg28 PF03694.13 ORX62753.1 - 7.4e-40 135.8 1.2 9.1e-40 135.5 1.2 1.1 1 0 0 1 1 1 1 Erg28 like protein Phyto_Pns9_10 PF05878.11 ORX62753.1 - 0.072 12.2 0.1 0.09 11.9 0.1 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns9/Pns10 UbiA PF01040.18 ORX62754.1 - 2.8e-54 184.1 13.4 3.5e-54 183.7 13.4 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family GCV_T PF01571.21 ORX62755.1 - 3.1e-08 33.3 0.0 5e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Ribosomal_L17 PF01196.19 ORX62756.1 - 1.2e-34 119.0 0.0 2.1e-34 118.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L17 Methyltransf_32 PF13679.6 ORX62757.1 - 0.0035 17.3 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf_CCCH_4 PF18345.1 ORX62757.1 - 0.021 14.9 1.1 0.044 13.9 1.1 1.6 1 0 0 1 1 1 0 Zinc finger domain Mito_carr PF00153.27 ORX62758.1 - 1.9e-44 149.5 8.1 2.3e-16 59.5 0.3 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF697 PF05128.12 ORX62758.1 - 0.11 12.2 0.9 1.3 8.8 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Ran_BP1 PF00638.18 ORX62759.1 - 3.8e-46 156.3 1.7 4.9e-46 156.0 1.7 1.1 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 ORX62759.1 - 0.00059 19.7 0.9 0.0031 17.4 0.9 1.9 1 1 0 1 1 1 1 WH1 domain DUF1681 PF07933.14 ORX62759.1 - 0.016 14.9 0.9 0.02 14.6 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1681) C2 PF00168.30 ORX62760.1 - 6.6e-07 29.6 0.0 8.5e-07 29.2 0.0 1.1 1 0 0 1 1 1 1 C2 domain Carn_acyltransf PF00755.20 ORX62761.1 - 1.6e-180 601.6 0.4 1.8e-180 601.4 0.4 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Transket_pyr PF02779.24 ORX62762.1 - 1.2e-62 210.8 0.0 2e-62 210.0 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ORX62762.1 - 1.4e-58 198.3 0.0 2e-58 197.7 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ORX62762.1 - 2.7e-53 179.8 0.0 4.6e-53 179.0 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ORX62762.1 - 2.3e-10 39.9 0.2 2.3e-10 39.9 0.2 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus MoCF_biosynth PF00994.24 ORX62764.1 - 2.7e-29 101.7 0.0 4e-29 101.1 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain IIGP PF05049.13 ORX62765.1 - 2.3e-30 105.9 0.6 7.3e-29 101.0 0.0 2.0 2 0 0 2 2 2 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 ORX62765.1 - 6.8e-09 35.8 0.0 1.3e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ORX62765.1 - 5.2e-07 29.9 0.0 1e-06 29.0 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ORX62765.1 - 5.4e-05 23.2 1.2 0.0038 17.2 0.1 2.3 1 1 1 2 2 2 1 RsgA GTPase Ras PF00071.22 ORX62765.1 - 0.00012 21.7 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 ORX62765.1 - 0.00013 21.5 0.0 0.00022 20.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 ORX62765.1 - 0.00097 19.7 0.8 0.0019 18.7 0.8 1.8 1 1 0 1 1 1 1 ABC transporter GTP_EFTU PF00009.27 ORX62765.1 - 0.001 18.6 1.4 0.1 12.2 1.4 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ORX62765.1 - 0.0039 17.3 1.4 0.013 15.6 1.4 2.2 1 1 0 1 1 1 1 Dynamin family DUF3641 PF12345.8 ORX62765.1 - 0.012 15.7 0.1 0.026 14.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) AIG1 PF04548.16 ORX62765.1 - 0.013 14.9 0.9 0.019 14.3 0.1 1.9 2 1 0 2 2 2 0 AIG1 family Septin PF00735.18 ORX62765.1 - 0.014 14.7 0.0 0.15 11.3 0.0 2.2 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 ORX62765.1 - 0.035 13.6 0.1 0.072 12.6 0.1 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ORX62765.1 - 0.11 12.2 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX62765.1 - 0.15 12.5 0.5 0.35 11.2 0.0 1.8 2 1 0 2 2 2 0 AAA ATPase domain DUF498 PF04430.14 ORX62766.1 - 1.8e-32 111.7 0.0 2.3e-32 111.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Stathmin PF00836.19 ORX62767.1 - 0.011 15.7 0.2 0.013 15.5 0.2 1.3 1 0 0 1 1 1 0 Stathmin family SVIP PF15811.5 ORX62767.1 - 1.8 9.1 11.1 8.7 6.9 11.1 2.1 1 1 0 1 1 1 0 Small VCP/p97-interacting protein ANAPC10 PF03256.16 ORX62768.1 - 4e-44 150.5 0.0 5.5e-44 150.0 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) DSPc PF00782.20 ORX62769.1 - 5.7e-07 29.4 0.0 7e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ORX62769.1 - 5.1e-06 26.2 0.0 5.3e-05 22.9 0.0 1.9 1 1 0 2 2 2 1 Protein-tyrosine phosphatase PQ-loop PF04193.14 ORX62770.1 - 1e-19 70.0 1.6 1e-19 70.0 1.6 2.4 2 0 0 2 2 2 1 PQ loop repeat zf-C2H2 PF00096.26 ORX62771.1 - 8.4e-13 48.0 6.4 1e-06 28.9 1.1 2.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX62771.1 - 1.3e-08 34.9 12.1 4e-06 27.0 0.1 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX62771.1 - 5.8e-08 32.9 5.7 0.00014 22.4 0.8 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 ORX62771.1 - 7.3e-06 26.2 0.6 0.0006 20.1 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ORX62771.1 - 2.7e-05 24.3 0.3 0.0008 19.6 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ORX62771.1 - 0.00053 19.9 0.3 0.00053 19.9 0.3 2.6 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ORX62771.1 - 0.046 13.6 4.9 2.1 8.3 0.9 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type FOXP-CC PF16159.5 ORX62771.1 - 0.088 13.4 1.0 0.21 12.3 0.3 1.8 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 ORX62771.1 - 0.11 12.8 1.5 0.29 11.5 0.2 1.9 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Zn_ribbon_SprT PF17283.2 ORX62771.1 - 2.7 8.0 7.5 2.9 7.9 1.8 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain ANAPC4_WD40 PF12894.7 ORX62772.1 - 1.1e-17 64.1 0.4 4.4e-05 23.7 0.0 5.3 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ORX62772.1 - 1.2e-17 64.0 6.5 0.00012 22.8 0.4 6.2 5 1 1 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 ORX62772.1 - 0.0003 20.7 0.1 0.0017 18.3 0.0 2.3 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ORX62772.1 - 0.0059 16.2 0.0 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 PQQ-like domain Coatomer_WDAD PF04053.14 ORX62772.1 - 0.013 14.6 0.2 0.059 12.4 0.2 2.1 1 1 0 1 1 1 0 Coatomer WD associated region MMS1_N PF10433.9 ORX62772.1 - 0.11 11.1 0.0 0.18 10.4 0.0 1.4 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40_like PF17005.5 ORX62772.1 - 0.12 11.7 0.0 52 3.0 0.0 3.1 2 1 2 4 4 4 0 WD40-like domain Cyclin PF08613.11 ORX62773.1 - 2.1e-08 34.7 0.0 2.7e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ORX62773.1 - 0.0091 15.7 1.6 0.022 14.5 1.6 1.6 1 1 0 1 1 1 1 Cyclin, N-terminal domain ORMDL PF04061.14 ORX62774.1 - 1.1e-55 187.2 7.2 1.2e-55 187.0 7.2 1.0 1 0 0 1 1 1 1 ORMDL family DAO PF01266.24 ORX62775.1 - 3e-58 198.1 0.1 3.4e-58 197.9 0.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ORX62775.1 - 0.00011 21.5 0.0 0.00037 19.8 0.0 1.8 2 0 0 2 2 2 1 Thi4 family NAD_binding_8 PF13450.6 ORX62775.1 - 0.00032 20.9 0.0 0.00095 19.3 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ORX62775.1 - 0.004 16.5 0.0 1.1 8.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ORX62775.1 - 0.012 14.6 0.0 0.024 13.7 0.0 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Mqo PF06039.15 ORX62775.1 - 0.044 12.3 0.0 0.06 11.9 0.0 1.1 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) NAD_Gly3P_dh_N PF01210.23 ORX62775.1 - 0.12 12.4 0.0 9.6 6.2 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Pkinase PF00069.25 ORX62776.1 - 7.5e-78 261.5 0.0 8.5e-78 261.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62776.1 - 4.9e-36 124.4 0.0 6e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ORX62776.1 - 8.2e-05 21.7 0.0 0.00037 19.6 0.0 1.8 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ORX62776.1 - 0.00012 21.5 0.1 0.006 15.9 0.0 2.2 1 1 0 2 2 2 1 Kinase-like APH PF01636.23 ORX62776.1 - 0.031 14.2 0.1 0.073 13.0 0.1 1.6 1 1 1 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 ORX62776.1 - 0.035 13.5 0.2 0.07 12.5 0.2 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ank_2 PF12796.7 ORX62777.1 - 1.6e-12 47.9 0.0 8.5e-12 45.5 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ORX62777.1 - 2.8e-12 46.9 0.0 1.9e-07 31.4 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ORX62777.1 - 4.2e-11 42.8 0.0 0.00012 22.4 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ORX62777.1 - 9.9e-11 40.9 0.0 0.00013 22.1 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ORX62777.1 - 2.5e-09 37.2 0.0 7.2e-08 32.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Tim44 PF04280.15 ORX62777.1 - 0.06 13.5 0.3 0.18 11.9 0.2 1.9 2 1 0 2 2 2 0 Tim44-like domain DUF2524 PF10732.9 ORX62777.1 - 0.19 12.0 1.7 0.54 10.6 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2524) Pkinase PF00069.25 ORX62778.1 - 1.3e-70 237.8 0.0 1.6e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62778.1 - 3.3e-37 128.2 0.0 2.4e-36 125.3 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX62778.1 - 4.5e-06 26.7 0.7 0.014 15.3 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ORX62778.1 - 2.5e-05 23.4 0.0 3.6e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ORX62778.1 - 0.0002 20.8 0.3 0.00034 20.0 0.3 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ORX62778.1 - 0.015 14.9 0.0 0.034 13.7 0.0 1.5 1 1 1 2 2 2 0 Choline/ethanolamine kinase TFIIF_beta PF02270.15 ORX62778.1 - 0.047 13.8 0.2 0.21 11.8 0.2 2.0 1 1 0 1 1 1 0 TFIIF, beta subunit HTH domain Kinase-like PF14531.6 ORX62778.1 - 0.17 11.2 0.1 0.47 9.7 0.0 1.7 2 1 0 2 2 2 0 Kinase-like mRNA_cap_enzyme PF01331.19 ORX62779.1 - 2.8e-33 115.4 0.0 4e-33 114.9 0.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ORX62779.1 - 0.00015 22.4 0.0 0.0018 18.9 0.0 2.4 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ORX62779.1 - 0.12 12.0 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain Myb_DNA-binding PF00249.31 ORX62780.1 - 9.3e-07 28.9 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ORX62780.1 - 0.0087 16.3 0.0 0.052 13.8 0.0 2.1 2 0 0 2 2 2 1 Myb-like DNA-binding domain Ribosomal_L10 PF00466.20 ORX62781.1 - 6.2e-23 80.8 0.0 9e-23 80.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 ORX62781.1 - 8.9e-23 80.1 0.0 1.6e-22 79.2 0.0 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P PBECR2 PF18810.1 ORX62781.1 - 0.15 12.3 0.0 0.39 11.0 0.0 1.6 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease2 GRIP PF01465.20 ORX62782.1 - 6.8e-11 41.9 1.8 3.4e-10 39.6 1.8 2.3 1 0 0 1 1 1 1 GRIP domain Rab_bind PF16704.5 ORX62782.1 - 0.011 15.8 0.7 0.011 15.8 0.7 3.4 5 1 0 6 6 6 0 Rab binding domain DUF4407 PF14362.6 ORX62782.1 - 0.014 14.8 43.1 0.09 12.1 1.2 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) GIT_CC PF16559.5 ORX62782.1 - 0.1 12.5 0.2 0.1 12.5 0.2 6.4 4 1 2 6 6 6 0 GIT coiled-coil Rho guanine nucleotide exchange factor VitD-bind_III PF09164.10 ORX62782.1 - 0.1 12.6 0.8 0.44 10.6 0.1 2.6 2 0 0 2 2 2 0 Vitamin D binding protein, domain III HAUS-augmin3 PF14932.6 ORX62782.1 - 0.1 12.1 0.2 0.1 12.1 0.2 5.0 3 1 3 6 6 5 0 HAUS augmin-like complex subunit 3 Spc7 PF08317.11 ORX62782.1 - 0.19 10.6 56.4 0.3 9.9 8.1 4.9 3 1 2 5 5 5 0 Spc7 kinetochore protein APG6_N PF17675.1 ORX62782.1 - 0.19 12.2 52.1 1.5 9.4 0.2 5.2 3 1 1 4 4 4 0 Apg6 coiled-coil region MCPVI PF02993.14 ORX62782.1 - 0.32 10.8 22.3 0.079 12.8 5.9 2.7 1 1 1 2 2 2 0 Minor capsid protein VI ATPase PF06745.13 ORX62782.1 - 0.76 9.1 13.9 1.2 8.4 3.6 3.3 2 1 1 3 3 3 0 KaiC CENP-F_leu_zip PF10473.9 ORX62782.1 - 1.6 8.8 51.3 6.8 6.7 1.4 4.9 3 1 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ADIP PF11559.8 ORX62782.1 - 1.7 8.7 63.4 1.4 9.0 1.6 5.2 3 1 2 5 5 5 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 ORX62782.1 - 3 8.1 57.4 0.34 11.1 4.6 5.5 3 1 2 5 5 5 0 JNK_SAPK-associated protein-1 Peptidase_M13 PF01431.21 ORX62782.1 - 5.5 6.5 10.1 0.46 10.1 4.0 2.1 1 1 1 2 2 2 0 Peptidase family M13 RicinB_lectin_2 PF14200.6 ORX62783.1 - 4e-15 56.3 0.0 6.5e-09 36.4 0.0 2.2 2 0 0 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ORX62783.1 - 2.6e-10 40.6 0.0 3.2e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Gal_GalNac_35kD PF17337.2 ORX62783.1 - 0.00032 20.8 0.1 0.41 10.6 0.1 2.3 1 1 1 2 2 2 2 Galactose-inhibitable lectin 35 kDa subunit HSP70 PF00012.20 ORX62784.1 - 2e-236 785.9 12.2 2.3e-236 785.7 12.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX62784.1 - 1.7e-18 66.5 2.1 2e-17 63.0 1.2 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ORX62784.1 - 0.0052 16.5 0.0 0.012 15.4 0.0 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Asp_decarbox PF02261.16 ORX62784.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Aspartate decarboxylase Raco_middle PF17651.1 ORX62784.1 - 0.14 11.9 0.5 3.9 7.1 0.0 3.2 2 1 1 3 3 3 0 RACo middle region eIF3_N PF09440.10 ORX62784.1 - 1.9 9.0 7.1 1.3 9.5 3.4 2.3 2 0 0 2 2 2 0 eIF3 subunit 6 N terminal domain LSM PF01423.22 ORX62785.1 - 2.5e-18 65.5 0.1 3.1e-18 65.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 ORX62785.1 - 0.0026 17.4 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 Hfq protein ABC_membrane_2 PF06472.15 ORX62786.1 - 3.8e-58 197.0 4.3 5.6e-58 196.5 4.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ORX62786.1 - 1.7e-20 73.9 0.0 3.2e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ORX62786.1 - 1.3e-06 28.0 0.0 0.02 14.3 0.1 2.3 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ORX62786.1 - 1.6e-05 24.9 0.0 2.6e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ORX62786.1 - 0.00014 22.4 0.2 0.00049 20.7 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ORX62786.1 - 0.00022 20.9 0.1 0.00047 19.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ORX62786.1 - 0.00059 20.3 0.5 0.0016 18.9 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 ORX62786.1 - 0.0012 18.5 0.1 0.0072 15.9 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ORX62786.1 - 0.0037 17.0 0.0 0.016 14.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ORX62786.1 - 0.0053 16.7 0.0 0.0098 15.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase NACHT PF05729.12 ORX62786.1 - 0.0097 15.8 0.0 0.023 14.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ORX62786.1 - 0.01 16.1 0.1 0.03 14.6 0.1 1.9 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ORX62786.1 - 0.041 13.6 0.2 0.17 11.6 0.0 2.1 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_28 PF13521.6 ORX62786.1 - 0.05 13.8 0.2 0.13 12.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Adeno_IVa2 PF02456.15 ORX62786.1 - 0.1 11.4 0.0 0.22 10.3 0.0 1.5 1 0 0 1 1 1 0 Adenovirus IVa2 protein MutS_V PF00488.21 ORX62786.1 - 0.1 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 MutS domain V T2SSE PF00437.20 ORX62786.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Cytidylate_kin PF02224.18 ORX62786.1 - 0.37 10.5 1.1 3 7.5 0.1 2.8 4 0 0 4 4 4 0 Cytidylate kinase PAP_central PF04928.17 ORX62787.1 - 1.3e-38 132.4 0.1 1.7e-22 79.6 0.0 2.2 2 0 0 2 2 2 2 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ORX62787.1 - 2.9e-10 40.0 0.1 6.2e-10 39.0 0.1 1.5 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 ORX62787.1 - 0.0007 19.8 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain GPI-anchored PF10342.9 ORX62788.1 - 4.3e-14 53.1 0.6 4.3e-14 53.1 0.6 2.0 2 0 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Melittin PF01372.17 ORX62788.1 - 0.13 12.3 0.1 0.4 10.7 0.1 1.8 1 0 0 1 1 1 0 Melittin FUSC_2 PF13515.6 ORX62789.1 - 2.5e-20 72.9 14.4 2.5e-20 72.9 14.4 2.7 2 0 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 ORX62789.1 - 1.7e-11 43.4 5.0 1.7e-11 43.4 5.0 2.8 2 1 0 3 3 3 2 Fusaric acid resistance protein family ArAE_2 PF10334.9 ORX62789.1 - 2.5e-08 34.0 1.8 2.8e-08 33.9 0.1 2.0 2 0 0 2 2 2 1 Aromatic acid exporter family member 2 ArAE_2_N PF10337.9 ORX62789.1 - 2.6e-06 26.8 0.8 2.6e-06 26.8 0.8 2.4 2 1 0 2 2 2 1 Putative ER transporter, 6TM, N-terminal ALMT PF11744.8 ORX62789.1 - 5.8e-06 25.4 14.8 0.00011 21.2 9.6 2.4 2 0 0 2 2 2 2 Aluminium activated malate transporter MARVEL PF01284.23 ORX62789.1 - 0.0014 18.7 14.1 0.0014 18.7 14.1 2.6 2 0 0 2 2 2 1 Membrane-associating domain ArAE_1 PF06081.11 ORX62789.1 - 0.65 10.1 13.2 0.013 15.6 5.3 2.4 2 0 0 2 2 2 0 Aromatic acid exporter family member 1 2OG-FeII_Oxy_2 PF13532.6 ORX62790.1 - 2.7e-13 50.6 0.0 5.8e-13 49.5 0.0 1.7 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily EF-1_beta_acid PF10587.9 ORX62790.1 - 8.1 7.0 7.1 19 5.8 7.1 1.6 1 0 0 1 1 1 0 Eukaryotic elongation factor 1 beta central acidic region Sacchrp_dh_NADP PF03435.18 ORX62791.1 - 1.5e-16 60.9 0.0 2.5e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 ORX62791.1 - 0.041 13.8 0.0 0.066 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Epimerase PF01370.21 ORX62791.1 - 0.14 11.6 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NIF PF03031.18 ORX62792.1 - 1.2e-54 184.3 0.6 1.4e-54 184.1 0.6 1.0 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase HAD PF12710.7 ORX62792.1 - 0.0015 19.0 0.1 0.014 15.8 0.0 2.1 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Replicase PF03090.17 ORX62792.1 - 0.033 14.0 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Replicase family RasGAP PF00616.19 ORX62794.1 - 1.4e-57 194.8 2.2 1.5e-57 194.6 0.0 2.2 3 0 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ORX62794.1 - 4.4e-34 117.6 0.0 4.4e-34 117.6 0.0 2.5 4 0 0 4 4 4 1 RasGAP C-terminus DUF3800 PF12686.7 ORX62794.1 - 0.066 13.9 0.8 0.49 11.0 0.8 2.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Herpes_UL14 PF03580.14 ORX62794.1 - 0.07 13.4 0.7 0.2 11.9 0.7 1.8 1 0 0 1 1 1 0 Herpesvirus UL14-like protein YabA PF06156.13 ORX62794.1 - 4.6 7.9 9.0 13 6.5 0.5 3.2 3 0 0 3 3 3 0 Initiation control protein YabA Cofilin_ADF PF00241.20 ORX62795.1 - 1.5e-20 73.2 0.0 1.8e-20 73.0 0.0 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein UCH PF00443.29 ORX62796.1 - 2.7e-37 128.7 0.1 3.6e-37 128.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 ORX62796.1 - 1.8e-12 47.4 0.6 3.4e-12 46.5 0.6 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 ORX62796.1 - 1.7e-10 41.0 0.0 4.1e-10 39.7 0.0 1.7 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Forkhead PF00250.18 ORX62797.1 - 4.1e-37 126.3 0.2 4.5e-37 126.2 0.2 1.0 1 0 0 1 1 1 1 Forkhead domain Linker_histone PF00538.19 ORX62797.1 - 0.052 13.9 0.1 0.083 13.3 0.1 1.4 1 1 0 1 1 1 0 linker histone H1 and H5 family Pkinase PF00069.25 ORX62798.1 - 1e-78 264.4 0.0 1.6e-78 263.7 0.0 1.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62798.1 - 4.5e-40 137.6 0.0 6.5e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62798.1 - 5.2e-06 26.0 0.0 8.8e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ORX62798.1 - 0.0013 18.7 0.0 0.0024 17.8 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX62798.1 - 0.0089 15.4 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PACT_coil_coil PF10495.9 ORX62798.1 - 0.019 15.6 0.3 0.053 14.1 0.3 1.7 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein FTA2 PF13095.6 ORX62798.1 - 0.089 12.4 0.6 2 8.0 0.0 2.7 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 RNA_pol_Rpb4 PF03874.16 ORX62799.1 - 3.6e-25 88.7 0.3 4.5e-25 88.4 0.3 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 DUF2757 PF10955.8 ORX62799.1 - 0.034 14.4 0.0 0.067 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) XPC-binding PF09280.11 ORX62799.1 - 0.082 12.7 0.7 0.51 10.1 0.1 2.6 2 1 1 3 3 3 0 XPC-binding domain Terminase_1 PF03354.15 ORX62799.1 - 0.2 10.2 0.0 0.23 10.0 0.0 1.1 1 0 0 1 1 1 0 Phage Terminase Baculo_PEP_C PF04513.12 ORX62800.1 - 8.7 6.4 8.4 4.7 7.3 1.4 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus EAF PF09816.9 ORX62801.1 - 5.7e-12 45.9 0.6 1.4e-11 44.6 0.6 1.7 1 0 0 1 1 1 1 RNA polymerase II transcription elongation factor BUD22 PF09073.10 ORX62801.1 - 1.5 8.1 20.3 0.59 9.4 6.2 2.2 2 0 0 2 2 2 0 BUD22 MAJIN PF15077.6 ORX62801.1 - 3.4 7.4 7.0 0.8 9.4 2.6 2.0 2 0 0 2 2 2 0 Membrane-anchored junction protein RPAP2_Rtr1 PF04181.13 ORX62806.1 - 9.8e-23 80.3 0.5 2.6e-22 78.9 0.5 1.8 1 0 0 1 1 1 1 Rtr1/RPAP2 family Ploopntkinase3 PF18751.1 ORX62806.1 - 0.098 12.6 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 DUF3275 PF11679.8 ORX62806.1 - 4.4 7.2 8.2 0.13 12.2 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3275) CK_II_beta PF01214.18 ORX62807.1 - 1.3e-66 223.9 0.0 2.1e-66 223.2 0.0 1.3 1 1 0 1 1 1 1 Casein kinase II regulatory subunit FYRC PF05965.14 ORX62808.1 - 3.3e-20 72.0 0.0 1.2e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 F/Y rich C-terminus FYRN PF05964.14 ORX62808.1 - 4.9e-17 61.5 0.0 7.9e-17 60.9 0.0 1.3 1 0 0 1 1 1 1 F/Y-rich N-terminus ERM PF00769.19 ORX62808.1 - 0.027 14.3 4.3 0.036 13.9 4.3 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF724 PF05266.14 ORX62808.1 - 0.16 11.8 2.5 0.25 11.1 2.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HSP70 PF00012.20 ORX62809.1 - 2.5e-259 861.5 5.5 2.9e-259 861.3 5.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX62809.1 - 3.1e-15 55.8 0.1 4.2e-14 52.1 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ORX62809.1 - 0.00042 20.1 0.0 0.0018 18.0 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 ORX62809.1 - 0.026 13.8 0.2 0.066 12.5 0.2 1.7 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase BcrAD_BadFG PF01869.20 ORX62809.1 - 0.041 13.4 0.0 7.2 6.0 0.0 2.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family StbA PF06406.11 ORX62809.1 - 0.18 11.0 1.9 0.75 9.0 0.0 2.2 2 0 0 2 2 2 0 StbA protein MutS_III PF05192.18 ORX62809.1 - 6.7 6.9 5.9 9.4 6.4 1.9 2.6 2 1 0 2 2 2 0 MutS domain III STE PF02200.16 ORX62810.1 - 7.9e-55 184.0 0.0 1.3e-54 183.3 0.0 1.3 1 0 0 1 1 1 1 STE like transcription factor zf-C2H2 PF00096.26 ORX62810.1 - 1.8e-09 37.5 13.0 2.9e-05 24.3 1.2 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ORX62810.1 - 7.1e-07 29.4 3.6 7.1e-07 29.4 3.6 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ORX62810.1 - 9.4e-07 29.2 10.4 0.0015 19.2 0.9 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ORX62810.1 - 3.2e-05 23.8 2.4 3.2e-05 23.8 2.4 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ORX62810.1 - 0.0029 17.8 4.2 0.16 12.3 0.2 2.5 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding p450 PF00067.22 ORX62812.1 - 5.5e-76 256.2 0.0 6.4e-76 256.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SWIB PF02201.18 ORX62813.1 - 3.5e-28 97.3 0.1 5.5e-28 96.7 0.1 1.3 1 0 0 1 1 1 1 SWIB/MDM2 domain U83 PF17465.2 ORX62815.1 - 0.0032 17.5 0.1 0.0048 17.0 0.1 1.2 1 0 0 1 1 1 1 Chemokine-like protein, HHV-6 U83 gene product NUDIX PF00293.28 ORX62816.1 - 9.2e-14 51.6 0.0 1.1e-13 51.3 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 ORX62816.1 - 0.00023 21.1 0.2 0.00074 19.5 0.2 1.7 1 1 0 1 1 1 1 NUDIX domain NMT_C PF02799.15 ORX62820.1 - 1.6e-80 269.5 0.0 2.3e-80 269.0 0.0 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 ORX62820.1 - 1.3e-73 246.1 0.1 7.4e-72 240.4 0.0 2.2 2 0 0 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain FMO-like PF00743.19 ORX62821.1 - 3.3e-42 144.6 0.0 2e-29 102.5 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ORX62821.1 - 3.7e-18 65.8 0.1 2.9e-12 46.5 0.0 2.9 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ORX62821.1 - 2.4e-15 56.5 0.0 6e-15 55.2 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ORX62821.1 - 1.2e-10 41.0 1.1 1.1e-07 31.3 0.0 3.0 2 1 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ORX62821.1 - 9.1e-09 35.5 10.7 9.4e-09 35.4 0.4 3.7 3 2 1 4 4 4 1 FAD-NAD(P)-binding DAO PF01266.24 ORX62821.1 - 3.4e-08 33.5 4.1 0.00095 18.8 0.1 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase HI0933_like PF03486.14 ORX62821.1 - 5.6e-08 31.9 0.0 0.00015 20.7 0.1 3.3 3 1 1 4 4 4 2 HI0933-like protein NAD_binding_8 PF13450.6 ORX62821.1 - 1.4e-07 31.6 0.0 1.7e-06 28.1 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ORX62821.1 - 1.1e-05 24.8 0.1 0.0011 18.3 0.1 2.3 2 0 0 2 2 2 1 Thi4 family Glu_dehyd_C PF16912.5 ORX62821.1 - 6.5e-05 22.5 0.0 0.15 11.5 0.0 2.9 2 1 1 3 3 3 2 Glucose dehydrogenase C-terminus Amino_oxidase PF01593.24 ORX62821.1 - 9.9e-05 21.8 0.2 0.018 14.3 0.0 3.2 4 1 0 4 4 4 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 ORX62821.1 - 0.00011 22.7 0.3 0.15 12.6 0.1 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Shikimate_DH PF01488.20 ORX62821.1 - 0.0013 18.8 0.0 0.11 12.6 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 ORX62821.1 - 0.018 14.1 2.7 0.019 14.1 0.1 2.0 2 0 0 2 2 2 0 FAD binding domain FAD_binding_3 PF01494.19 ORX62821.1 - 0.019 14.2 1.6 0.13 11.5 0.0 2.3 2 1 0 2 2 2 0 FAD binding domain FAD_oxidored PF12831.7 ORX62821.1 - 0.034 13.5 0.0 0.11 11.8 0.0 1.9 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ORX62821.1 - 0.071 12.2 0.1 0.18 10.8 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 ORX62821.1 - 0.095 13.2 0.1 22 5.6 0.1 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Peptidase_C42 PF05533.12 ORX62821.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Beet yellows virus-type papain-like endopeptidase C42 TrkA_N PF02254.18 ORX62821.1 - 0.14 12.5 0.6 0.76 10.1 0.0 2.4 3 0 0 3 3 2 0 TrkA-N domain AlaDh_PNT_C PF01262.21 ORX62821.1 - 0.16 11.3 1.0 1.7 7.9 0.1 2.1 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 ORX62821.1 - 0.65 9.0 2.1 1.3 8.1 0.3 2.2 2 1 1 3 3 3 0 Glucose inhibited division protein A Peptidase_S9 PF00326.21 ORX62822.1 - 2e-46 158.1 0.2 3.4e-46 157.4 0.2 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 ORX62822.1 - 0.00079 19.1 0.4 0.0016 18.2 0.4 1.4 1 0 0 1 1 1 1 Putative esterase AXE1 PF05448.12 ORX62822.1 - 0.024 13.3 0.0 0.18 10.5 0.0 2.3 2 1 0 2 2 2 0 Acetyl xylan esterase (AXE1) DLH PF01738.18 ORX62822.1 - 0.13 11.8 0.0 0.27 10.7 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family Copper-fist PF00649.18 ORX62824.1 - 3.1e-19 68.2 2.2 3.1e-19 68.2 2.2 1.6 2 0 0 2 2 2 1 Copper fist DNA binding domain Plasmod_Pvs28 PF06247.11 ORX62824.1 - 0.034 14.5 0.4 0.034 14.5 0.4 1.6 2 0 0 2 2 2 0 Pvs28 EGF domain DUF5008 PF16400.5 ORX62824.1 - 0.12 12.5 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5008) EIF_2_alpha PF07541.12 ORX62826.1 - 1.1e-36 125.4 0.5 1.9e-36 124.7 0.1 1.6 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ORX62826.1 - 1.5e-13 50.9 1.7 3.9e-13 49.5 1.7 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Adaptin_binding PF10199.9 ORX62826.1 - 0.14 12.8 1.0 0.27 11.9 1.0 1.4 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Adaptin_N PF01602.20 ORX62827.1 - 1.7e-142 475.6 9.0 1.9e-142 475.5 9.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ORX62827.1 - 1e-22 80.9 4.6 4.3e-18 65.9 0.0 4.2 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ORX62827.1 - 8.7e-08 32.5 1.9 0.034 14.5 0.0 4.5 3 2 3 6 6 6 3 HEAT repeats HEAT PF02985.22 ORX62827.1 - 0.00025 21.0 2.6 0.57 10.6 0.0 5.6 7 0 0 7 7 7 1 HEAT repeat CLASP_N PF12348.8 ORX62827.1 - 0.011 15.3 1.0 1.9 8.0 0.2 2.9 2 1 0 2 2 2 0 CLASP N terminal Cohesin_HEAT PF12765.7 ORX62827.1 - 0.011 16.0 0.0 0.041 14.2 0.0 2.0 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion DUF4186 PF13811.6 ORX62827.1 - 0.13 12.3 0.0 2.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) Peptidase_S8 PF00082.22 ORX62828.1 - 5.6e-32 111.2 7.9 5.6e-32 111.2 7.9 2.3 2 1 0 2 2 2 1 Subtilase family MID_MedPIWI PF18296.1 ORX62829.1 - 0.044 13.6 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 MID domain of medPIWI FAM104 PF15434.6 ORX62829.1 - 8.8 6.9 7.5 13 6.4 0.3 3.3 3 0 0 3 3 3 0 Family 104 RasGAP PF00616.19 ORX62830.1 - 2.6e-23 82.8 0.4 8.6e-15 55.0 0.0 3.3 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase CRAL_TRIO_2 PF13716.6 ORX62830.1 - 1.7e-19 70.3 0.2 8.2e-19 68.1 0.2 2.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Cnd1 PF12717.7 ORX62830.1 - 0.00023 21.3 0.8 0.0013 18.8 0.1 2.8 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MOR2-PAG1_C PF14225.6 ORX62830.1 - 0.00099 19.0 1.1 0.0091 15.9 0.2 3.1 2 0 0 2 2 2 1 Cell morphogenesis C-terminal Adaptin_N PF01602.20 ORX62830.1 - 0.0015 17.1 2.5 0.23 10.0 0.1 3.9 3 1 0 3 3 3 2 Adaptin N terminal region HEAT_2 PF13646.6 ORX62830.1 - 0.071 13.5 0.3 1.4 9.4 0.1 3.5 4 0 0 4 4 4 0 HEAT repeats HEAT PF02985.22 ORX62830.1 - 5.3 7.6 12.1 0.41 11.0 0.1 5.0 5 0 0 5 5 5 0 HEAT repeat Peptidase_M13 PF01431.21 ORX62831.1 - 7.2e-68 228.2 0.3 1.1e-67 227.7 0.3 1.3 1 0 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 ORX62831.1 - 1.6e-67 228.8 0.0 2.7e-67 228.1 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M13 ADH_N PF08240.12 ORX62832.1 - 4.7e-19 68.3 1.5 8e-19 67.5 1.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ORX62832.1 - 5.9e-19 68.3 0.0 1.1e-18 67.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 ORX62832.1 - 7.5e-07 28.7 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ORX62832.1 - 0.00054 21.0 0.0 0.001 20.1 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX62832.1 - 0.0018 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 ORX62832.1 - 0.0026 18.6 0.0 0.0042 17.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Glu_dehyd_C PF16912.5 ORX62832.1 - 0.011 15.2 0.0 0.018 14.6 0.0 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus ELFV_dehydrog PF00208.21 ORX62832.1 - 0.033 13.9 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 ORX62832.1 - 0.067 13.5 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain Oxysterol_BP PF01237.18 ORX62833.1 - 4.6e-110 368.0 3.6 4.6e-110 368.0 3.6 1.8 2 1 0 2 2 2 1 Oxysterol-binding protein PH_8 PF15409.6 ORX62833.1 - 2.6e-20 72.5 0.2 6.3e-20 71.3 0.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ORX62833.1 - 3.6e-08 33.8 0.5 3.9e-07 30.5 0.1 2.8 2 0 0 2 2 2 1 PH domain GOLD_2 PF13897.6 ORX62833.1 - 7.9e-07 29.6 0.0 7.9e-07 29.6 0.0 2.6 3 0 0 3 3 3 1 Golgi-dynamics membrane-trafficking PH_11 PF15413.6 ORX62833.1 - 0.00014 22.2 1.5 0.81 10.1 0.2 3.1 2 0 0 2 2 2 2 Pleckstrin homology domain EMP24_GP25L PF01105.24 ORX62833.1 - 0.33 10.9 4.2 3.1 7.7 0.3 2.8 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD COG7 PF10191.9 ORX62834.1 - 2.1e-15 56.1 12.3 1.9e-12 46.3 8.1 2.0 2 0 0 2 2 2 2 Golgi complex component 7 (COG7) Hemolysin_N PF12563.8 ORX62834.1 - 0.019 14.6 1.8 0.026 14.1 1.6 1.3 1 1 0 1 1 1 0 Hemolytic toxin N terminal AAA_23 PF13476.6 ORX62834.1 - 0.15 12.5 5.2 0.19 12.2 5.2 1.1 1 0 0 1 1 1 0 AAA domain COG2 PF06148.11 ORX62834.1 - 0.72 9.9 6.7 30 4.7 4.4 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 CENP-H PF05837.12 ORX62834.1 - 2.3 8.6 11.2 0.47 10.9 5.4 2.1 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF948 PF06103.11 ORX62834.1 - 3.2 8.1 6.1 2.9 8.2 3.4 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ADH_zinc_N PF00107.26 ORX62835.1 - 4.2e-20 72.0 0.0 7.7e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ORX62835.1 - 5.7e-20 71.2 1.7 9.1e-20 70.6 1.7 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 ORX62835.1 - 6.1e-06 25.7 0.0 1.4e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 ORX62835.1 - 0.00042 21.4 0.0 0.00074 20.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ORX62835.1 - 0.0026 17.2 0.0 0.0042 16.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 ORX62835.1 - 0.0032 17.0 0.0 0.0047 16.5 0.0 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus GFO_IDH_MocA PF01408.22 ORX62835.1 - 0.004 18.0 0.0 0.0066 17.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.18 ORX62835.1 - 0.1 12.8 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ORX62835.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Thyroglobulin_1 PF00086.18 ORX62836.1 - 0.1 12.3 0.5 0.5 10.1 0.0 2.1 2 1 0 2 2 2 0 Thyroglobulin type-1 repeat Phage_HK97_TLTM PF06120.11 ORX62838.1 - 0.21 10.7 3.1 0.3 10.2 3.1 1.1 1 0 0 1 1 1 0 Tail length tape measure protein CCDC-167 PF15188.6 ORX62838.1 - 0.26 11.6 11.7 0.52 10.7 11.7 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF3552 PF12072.8 ORX62838.1 - 0.29 10.5 10.9 0.53 9.7 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) V_ATPase_I PF01496.19 ORX62838.1 - 3.4 5.5 4.3 4.2 5.2 4.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HMG-CoA_red PF00368.18 ORX62839.1 - 4.3e-145 483.3 4.4 6e-145 482.9 4.4 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Sterol-sensing PF12349.8 ORX62839.1 - 4.3e-16 59.1 5.0 1.1e-15 57.8 5.0 1.7 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ORX62839.1 - 0.00024 19.4 11.7 0.00027 19.2 10.8 1.4 1 1 0 1 1 1 1 Patched family HPIH PF13323.6 ORX62839.1 - 0.00075 19.4 1.0 0.0023 17.8 0.1 2.1 2 0 0 2 2 2 1 N-terminal domain with HPIH motif PLDc PF00614.22 ORX62840.1 - 2.6e-18 65.4 2.1 1.9e-09 37.3 0.1 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX62840.1 - 2.7e-16 59.7 0.5 4.8e-07 29.7 0.0 3.4 3 0 0 3 3 3 3 PLD-like domain PX PF00787.24 ORX62840.1 - 3.3e-09 36.7 0.0 8.4e-09 35.4 0.0 1.7 1 0 0 1 1 1 1 PX domain PH PF00169.29 ORX62840.1 - 5.3e-05 23.7 2.2 0.00025 21.5 0.9 2.7 2 0 0 2 2 2 1 PH domain LtuB PF17455.2 ORX62840.1 - 0.1 13.2 0.0 8.3 7.1 0.0 2.7 2 0 0 2 2 2 0 Late transcription unit B Pkinase PF00069.25 ORX62841.1 - 2.4e-74 250.0 0.0 3e-74 249.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62841.1 - 2.3e-32 112.3 0.0 3e-32 111.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62841.1 - 2.1e-06 27.3 0.0 3.7e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ORX62841.1 - 0.00022 20.6 0.1 0.00035 20.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ORX62841.1 - 0.0012 17.7 0.0 0.0022 16.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ORX62841.1 - 0.012 15.5 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ORX62841.1 - 0.059 12.9 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL SEN1_N PF12726.7 ORX62841.1 - 0.061 11.5 0.0 0.086 11.0 0.0 1.2 1 0 0 1 1 1 0 SEN1 N terminal NtA PF03146.15 ORX62841.1 - 0.099 12.5 0.0 0.35 10.8 0.0 1.9 2 0 0 2 2 2 0 Agrin NtA domain PAP2 PF01569.21 ORX62842.1 - 0.00061 19.6 7.9 0.0038 17.0 0.3 3.5 2 1 1 3 3 3 2 PAP2 superfamily DUF212 PF02681.14 ORX62842.1 - 0.002 18.3 1.0 0.13 12.4 0.0 2.4 1 1 1 2 2 2 2 Divergent PAP2 family DUF3482 PF11981.8 ORX62842.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) AcetylCoA_hydro PF02550.15 ORX62843.1 - 1.7e-51 175.0 0.0 2.3e-51 174.6 0.0 1.2 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 ORX62843.1 - 3.8e-39 134.1 0.0 5.6e-39 133.5 0.0 1.3 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CoA_trans PF01144.23 ORX62843.1 - 0.14 11.5 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 Coenzyme A transferase CitF PF04223.12 ORX62843.1 - 0.16 10.8 0.0 0.26 10.1 0.0 1.2 1 0 0 1 1 1 0 Citrate lyase, alpha subunit (CitF) KTI12 PF08433.10 ORX62844.1 - 0.042 13.3 0.0 0.052 13.0 0.0 1.1 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Exo_endo_phos PF03372.23 ORX62845.1 - 0.0012 18.4 0.1 0.0015 18.1 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Lipase_3 PF01764.25 ORX62846.1 - 9.2e-27 93.6 0.0 1.3e-26 93.2 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.20 ORX62846.1 - 0.0011 18.7 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DUF2974 PF11187.8 ORX62846.1 - 0.041 13.4 0.1 0.081 12.5 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ORX62846.1 - 0.049 14.2 0.1 0.083 13.5 0.1 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ORX62846.1 - 0.065 12.5 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 F-box-like PF12937.7 ORX62847.1 - 3.6e-06 26.8 0.4 4.1e-06 26.6 0.4 1.1 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62847.1 - 6.7e-05 22.7 0.2 9.6e-05 22.2 0.2 1.1 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 ORX62847.1 - 0.028 14.7 0.1 0.035 14.4 0.1 1.1 1 0 0 1 1 1 0 PRANC domain Lipase_3 PF01764.25 ORX62848.1 - 3e-22 79.0 0.0 4.7e-22 78.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) PGAP1 PF07819.13 ORX62848.1 - 0.019 14.7 0.0 0.04 13.6 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein Hydrolase_4 PF12146.8 ORX62848.1 - 0.038 13.3 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ORX62848.1 - 0.1 13.2 0.0 0.15 12.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF2974 PF11187.8 ORX62848.1 - 0.12 11.9 0.0 0.18 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) DUF676 PF05057.14 ORX62848.1 - 0.22 11.0 0.0 0.33 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative serine esterase (DUF676) F-box-like PF12937.7 ORX62849.1 - 0.00021 21.1 0.1 0.001 18.9 0.1 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62849.1 - 0.00042 20.1 0.2 0.0025 17.6 0.1 2.4 2 0 0 2 2 2 1 F-box domain Zn_clus PF00172.18 ORX62851.1 - 1.3e-05 25.2 10.9 1.3e-05 25.2 10.9 1.6 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 ORX62851.1 - 0.026 14.5 0.0 0.049 13.6 0.0 1.4 1 0 0 1 1 1 0 PAS fold DUF2514 PF10721.9 ORX62852.1 - 0.044 13.8 0.8 0.078 13.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Frag1 PF10277.9 ORX62853.1 - 5.5e-38 130.7 9.6 5.5e-38 130.7 9.6 3.0 3 2 0 3 3 3 1 Frag1/DRAM/Sfk1 family SIP1 PF04938.12 ORX62854.1 - 1.6e-27 96.7 0.0 2e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) SRR1 PF07985.12 ORX62854.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 SRR1 TPR_1 PF00515.28 ORX62856.1 - 1e-21 75.8 0.0 0.00012 21.8 0.0 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62856.1 - 1.2e-17 62.5 0.0 0.002 18.1 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62856.1 - 2e-17 62.6 0.2 5.9e-06 25.9 0.0 4.0 2 1 2 4 4 4 3 TPR repeat TPR_16 PF13432.6 ORX62856.1 - 1.4e-15 57.6 0.1 3.9e-07 30.6 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62856.1 - 1.8e-12 47.4 3.3 0.028 14.7 0.3 4.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ORX62856.1 - 1.1e-10 41.1 1.4 0.062 13.7 0.1 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62856.1 - 2.8e-10 40.1 0.4 0.021 15.6 0.1 4.5 4 1 1 5 5 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62856.1 - 6.5e-09 35.3 0.0 0.63 10.4 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62856.1 - 2e-08 33.7 1.1 0.45 10.7 0.0 5.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_9 PF13371.6 ORX62856.1 - 3.2e-08 33.6 0.1 0.11 12.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62856.1 - 7.8e-08 32.7 0.0 0.53 10.8 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_20 PF14561.6 ORX62856.1 - 1.4e-07 31.8 0.0 0.42 11.0 0.1 3.7 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 ORX62856.1 - 4.2e-06 26.2 0.1 0.0044 16.3 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62856.1 - 4.1e-05 23.9 0.0 2.8 8.8 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62856.1 - 0.00028 21.0 0.8 0.02 15.1 0.2 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ORX62856.1 - 0.00035 20.6 0.3 1.6 8.9 0.1 3.7 3 1 1 4 4 4 1 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ORX62856.1 - 0.00073 19.3 0.0 0.087 12.5 0.1 3.0 1 1 2 3 3 3 1 26S proteasome subunit RPN7 TPR_10 PF13374.6 ORX62856.1 - 0.0039 17.0 6.7 0.46 10.4 1.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ORX62856.1 - 0.0076 16.2 0.0 8.6 6.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Stork_head PF10264.9 ORX62856.1 - 0.11 12.7 0.0 0.37 11.0 0.0 1.8 2 0 0 2 2 1 0 Winged helix Storkhead-box1 domain U1snRNP70_N PF12220.8 ORX62856.1 - 0.16 12.6 0.5 1.2 9.9 0.0 2.5 3 0 0 3 3 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF1641 PF07849.11 ORX62856.1 - 0.19 11.6 0.2 0.44 10.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) GLTT PF01744.20 ORX62857.1 - 9.2e-31 104.9 205.8 0.0027 17.4 0.8 23.9 2 2 21 27 27 27 27 GLTT repeat (6 copies) Lamprin PF06403.11 ORX62857.1 - 1.9 8.5 105.7 5.3 7.0 4.6 11.9 1 1 6 7 7 7 0 Lamprin Pentapeptide PF00805.22 ORX62858.1 - 9.8e-05 21.9 0.0 1.2 8.9 0.0 3.0 1 1 3 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ORX62858.1 - 0.0079 16.3 0.0 0.017 15.3 0.0 1.6 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) NRBF2 PF08961.10 ORX62858.1 - 0.18 11.4 16.9 5.5 6.6 2.3 3.7 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Pentapeptide PF00805.22 ORX62859.1 - 1e-05 25.1 0.0 5.5 6.7 0.0 4.1 2 1 1 4 4 4 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ORX62859.1 - 0.00019 21.5 0.0 0.17 12.0 0.0 2.9 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) NRBF2 PF08961.10 ORX62859.1 - 5.1 6.6 23.0 12 5.5 1.6 4.9 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator Pentapeptide PF00805.22 ORX62860.1 - 2.4e-05 23.9 0.0 7.1 6.4 0.0 4.2 2 1 1 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ORX62860.1 - 3.9e-05 23.7 0.0 0.037 14.2 0.0 2.5 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ORX62861.1 - 1.7e-11 44.1 0.0 0.02 15.1 0.0 4.4 2 1 3 5 5 5 5 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ORX62861.1 - 2.1e-11 43.2 0.0 0.13 11.9 0.0 6.4 3 1 3 8 8 8 6 Pentapeptide repeats (8 copies) GLTT PF01744.20 ORX62862.1 - 4.8e-09 35.7 61.6 0.032 14.0 0.7 6.5 3 1 2 6 6 6 6 GLTT repeat (6 copies) Lamprin PF06403.11 ORX62862.1 - 0.0038 17.2 25.7 11 5.9 7.0 4.7 1 1 1 2 2 2 1 Lamprin Pentapeptide PF00805.22 ORX62863.1 - 3.3e-06 26.6 0.0 3.3 7.5 0.0 3.9 2 1 0 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ORX62863.1 - 2.8e-05 24.2 0.0 0.12 12.5 0.0 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) NRBF2 PF08961.10 ORX62863.1 - 0.49 10.0 25.5 1.8e+04 -14.5 25.5 5.0 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Coleoptericin PF06286.11 ORX62863.1 - 0.83 9.8 5.6 5.2 7.2 0.6 2.9 1 1 2 3 3 3 0 Coleoptericin HGTP_anticodon PF03129.20 ORX62865.1 - 2.8e-24 85.1 0.3 2.4e-23 82.1 0.0 2.7 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ORX62865.1 - 3e-09 37.1 0.1 1.1e-08 35.2 0.1 2.0 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) InPase PF18823.1 ORX62865.1 - 0.0084 15.8 0.1 0.046 13.4 0.0 2.3 3 0 0 3 3 3 1 Inorganic Pyrophosphatase zf-RVT PF13966.6 ORX62866.1 - 2.2e-05 25.1 0.4 3.9e-05 24.3 0.4 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase E1-E2_ATPase PF00122.20 ORX62867.1 - 8.2e-40 136.2 1.2 1.6e-39 135.3 0.1 2.1 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ORX62867.1 - 5.8e-17 62.7 0.0 1.2e-16 61.7 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 ORX62867.1 - 1.4e-12 47.1 0.1 5.8e-12 45.1 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cation_ATPase_C PF00689.21 ORX62867.1 - 3.4e-10 39.9 8.4 4.9e-10 39.4 5.4 2.3 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX62867.1 - 5e-08 32.9 0.0 1.3e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ORX62867.1 - 0.013 15.3 0.7 0.041 13.6 0.0 2.2 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase RRM_1 PF00076.22 ORX62868.1 - 9.5e-37 124.7 0.0 8.8e-19 67.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1918 PF08940.11 ORX62868.1 - 0.16 11.6 1.2 7.4 6.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF1918) Chorismate_synt PF01264.21 ORX62869.1 - 4.7e-135 449.5 0.0 5.3e-135 449.3 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase FANCI_S4 PF14678.6 ORX62870.1 - 1.9e-51 174.6 3.5 1.9e-51 174.6 3.5 2.1 2 0 0 2 2 2 1 FANCI solenoid 4 FANCI_HD2 PF14680.6 ORX62870.1 - 1.4e-32 112.9 2.4 2.1e-32 112.3 0.9 2.1 2 0 0 2 2 2 1 FANCI helical domain 2 FANCI_S1 PF14675.6 ORX62870.1 - 2.7e-30 105.6 1.4 1.1e-29 103.7 0.3 2.5 2 1 0 2 2 2 1 FANCI solenoid 1 FANCI_S2 PF14676.6 ORX62870.1 - 6.9e-29 101.3 3.5 3.3e-28 99.0 0.1 3.1 3 0 0 3 3 3 1 FANCI solenoid 2 FANCI_HD1 PF14679.6 ORX62870.1 - 4.5e-19 68.2 2.6 8.9e-19 67.2 0.5 2.8 3 0 0 3 3 3 1 FANCI helical domain 1 FANCI_S3 PF14677.6 ORX62870.1 - 5.1e-10 39.4 0.0 5.1e-10 39.4 0.0 2.7 3 0 0 3 3 3 1 FANCI solenoid 3 MSSP PF03940.13 ORX62872.1 - 0.077 12.6 35.8 7.1e+02 -0.1 35.8 2.8 1 1 0 1 1 1 0 Male specific sperm protein Keratin_B2_2 PF13885.6 ORX62872.1 - 5.2 7.1 24.1 2.3e+03 -1.4 24.1 2.8 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein DUF4167 PF13763.6 ORX62873.1 - 0.028 14.6 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4167) Mon1 PF03164.14 ORX62874.1 - 7.4e-149 496.2 7.4 8.6e-149 496.0 7.4 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 Redoxin PF08534.10 ORX62874.1 - 0.051 13.3 0.0 5 6.8 0.0 2.5 2 0 0 2 2 2 0 Redoxin SBDS_C PF09377.10 ORX62875.1 - 2.6e-39 133.9 2.9 2.6e-39 133.9 2.9 1.8 2 1 0 2 2 2 1 SBDS protein C-terminal domain SBDS PF01172.18 ORX62875.1 - 1.6e-35 121.0 0.9 3.6e-35 119.9 0.9 1.6 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein HTH_22 PF13309.6 ORX62875.1 - 0.12 12.5 0.7 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 HTH domain Myb_DNA-bind_3 PF12776.7 ORX62875.1 - 0.12 13.4 1.1 0.48 11.5 0.2 2.3 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Peptidase_M28 PF04389.17 ORX62876.1 - 1.4e-36 126.0 0.0 3.4e-36 124.8 0.0 1.6 1 1 0 1 1 1 1 Peptidase family M28 Zn_ribbon_17 PF17120.5 ORX62877.1 - 1.2e-10 40.9 16.2 1.2e-10 40.9 16.2 2.4 1 1 1 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 ORX62877.1 - 2.6e-09 37.6 13.4 0.0033 18.2 0.6 6.2 5 0 0 5 5 5 2 WD domain, G-beta repeat zinc_ribbon_16 PF17034.5 ORX62877.1 - 1.8e-06 28.1 11.7 4.4e-06 26.9 11.7 1.6 1 0 0 1 1 1 1 Zinc-ribbon like family PHF5 PF03660.14 ORX62877.1 - 0.021 15.0 8.0 0.042 14.0 8.0 1.4 1 0 0 1 1 1 0 PHF5-like protein Rav1p_C PF12234.8 ORX62877.1 - 0.047 12.1 1.4 1.4 7.3 0.1 2.1 1 1 1 2 2 2 0 RAVE protein 1 C terminal ANAPC4_WD40 PF12894.7 ORX62877.1 - 0.19 12.0 3.4 0.95 9.8 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DZR PF12773.7 ORX62877.1 - 0.76 9.8 9.9 1.8 8.6 9.9 1.7 1 0 0 1 1 1 0 Double zinc ribbon 14-3-3 PF00244.20 ORX62878.1 - 4e-105 350.2 6.4 4.7e-105 350.0 6.4 1.0 1 0 0 1 1 1 1 14-3-3 protein YabA PF06156.13 ORX62878.1 - 0.46 11.1 2.2 0.69 10.6 0.2 2.0 2 0 0 2 2 2 0 Initiation control protein YabA XhlA PF10779.9 ORX62878.1 - 0.46 10.7 3.0 0.3 11.3 0.4 2.0 2 0 0 2 2 2 0 Haemolysin XhlA MFS_1_like PF12832.7 ORX62879.1 - 3e-24 85.6 5.3 3.8e-24 85.3 5.3 1.1 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ORX62879.1 - 7.2e-07 28.5 12.7 1.4e-05 24.2 12.8 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily Gti1_Pac2 PF09729.9 ORX62880.1 - 8.7e-56 188.9 0.4 6.9e-53 179.4 0.4 2.4 1 1 0 1 1 1 1 Gti1/Pac2 family Cpn60_TCP1 PF00118.24 ORX62881.1 - 3.8e-86 289.7 10.1 7.7e-86 288.7 10.1 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family YajC PF02699.15 ORX62881.1 - 0.51 10.3 2.3 0.67 9.9 0.5 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit zf-C2H2_aberr PF17017.5 ORX62882.1 - 1.1e-07 32.2 7.2 0.0013 19.0 1.0 2.2 1 1 1 2 2 2 2 Aberrant zinc-finger zf-C2H2 PF00096.26 ORX62882.1 - 0.00023 21.4 11.4 0.0089 16.4 0.6 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ORX62882.1 - 0.009 16.3 1.3 0.019 15.3 0.2 1.9 2 0 0 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ORX62882.1 - 0.01 16.6 14.9 0.29 12.1 1.4 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf_Hakai PF18408.1 ORX62882.1 - 0.27 11.0 0.3 0.27 11.0 0.3 2.6 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain FOXP-CC PF16159.5 ORX62882.1 - 1.3 9.7 11.0 8.4 7.1 0.3 3.4 2 1 1 3 3 3 0 FOXP coiled-coil domain E7 PF00527.18 ORX62882.1 - 3.1 8.1 9.5 0.87 9.8 5.6 2.0 2 0 0 2 2 2 0 E7 protein, Early protein RasGEF PF00617.19 ORX62883.1 - 3.9e-41 141.2 0.1 1e-40 139.8 0.0 1.7 2 0 0 2 2 2 1 RasGEF domain Peptidase_M16_C PF05193.21 ORX62884.1 - 3.9e-30 105.2 0.0 7.5e-30 104.3 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ORX62884.1 - 3.6e-14 53.0 0.9 3.6e-14 53.0 0.9 2.1 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M17_N PF02789.17 ORX62884.1 - 0.013 15.4 0.5 0.054 13.4 0.5 2.0 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain Mito_carr PF00153.27 ORX62885.1 - 5.7e-67 221.7 1.6 4.9e-23 80.9 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PH PF00169.29 ORX62886.1 - 0.0032 17.9 0.0 0.014 15.9 0.0 2.1 2 0 0 2 2 2 1 PH domain MBOAT_2 PF13813.6 ORX62887.1 - 2.8e-11 43.5 5.5 3.1e-11 43.4 3.6 2.2 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family DUF3392 PF11872.8 ORX62887.1 - 0.45 10.8 6.2 1.5 9.2 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3392) RNA12 PF10443.9 ORX62891.1 - 5.3e-106 355.0 0.1 5.2e-64 216.6 0.0 2.1 1 1 1 2 2 2 2 RNA12 protein ATPase_2 PF01637.18 ORX62891.1 - 7.1e-07 29.4 0.0 3.4e-05 23.9 0.0 2.6 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 ORX62891.1 - 1.2e-06 28.3 0.0 2.7e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_16 PF13191.6 ORX62891.1 - 3.9e-05 24.1 0.0 7.6e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ORX62891.1 - 0.0048 17.2 0.0 0.025 14.9 0.0 2.2 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 ORX62891.1 - 0.026 14.3 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase RRM_occluded PF16842.5 ORX62891.1 - 0.027 14.3 0.0 2.8 7.9 0.0 3.2 3 0 0 3 3 3 0 Occluded RNA-recognition motif AAA_24 PF13479.6 ORX62891.1 - 0.035 13.8 0.0 0.069 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ORX62891.1 - 0.047 12.9 0.0 0.1 11.8 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_33 PF13671.6 ORX62891.1 - 0.093 12.9 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX62891.1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TFIIA PF03153.13 ORX62892.1 - 4.3e-62 211.4 11.4 7.3e-39 134.9 9.7 2.8 1 1 1 2 2 2 2 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 ORX62892.1 - 1.3 8.7 5.2 2 8.1 5.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ArfGap PF01412.18 ORX62893.1 - 8.2e-21 74.3 0.1 1.2e-20 73.8 0.1 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Sulfotransfer_4 PF17784.1 ORX62894.1 - 2.4e-66 223.7 0.0 2.7e-66 223.5 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ORX62894.1 - 9.8e-06 26.1 0.7 0.0002 21.8 0.1 2.2 1 1 1 2 2 2 1 Sulfotransferase family Pkinase PF00069.25 ORX62895.1 - 4.9e-49 167.1 0.0 7.5e-49 166.5 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62895.1 - 3.3e-23 82.3 0.0 4.5e-23 81.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ORX62895.1 - 1.6e-09 37.5 0.7 0.00022 20.6 0.0 2.1 1 1 1 2 2 2 2 Kinase-like FTA2 PF13095.6 ORX62895.1 - 0.023 14.3 0.1 0.11 12.1 0.1 2.0 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ORX62895.1 - 0.06 13.3 0.2 5 7.0 0.0 2.8 2 1 1 3 3 3 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ORX62895.1 - 0.17 10.6 1.3 1.1 8.0 0.0 1.9 1 1 1 2 2 2 0 Fungal protein kinase HSP70 PF00012.20 ORX62896.1 - 9.6e-06 24.1 0.0 1.7e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX62896.1 - 0.06 12.2 0.0 0.17 10.6 0.0 1.6 2 0 0 2 2 2 0 MreB/Mbl protein DUF848 PF05852.11 ORX62897.1 - 0.012 15.8 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) Pkinase PF00069.25 ORX62898.1 - 8.4e-24 84.3 0.0 2.5e-23 82.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ORX62898.1 - 2.1e-12 47.3 2.8 1.1e-05 26.0 0.2 5.6 6 0 0 6 6 6 2 WD domain, G-beta repeat HEAT PF02985.22 ORX62898.1 - 2.6e-12 45.9 3.1 0.14 12.5 0.1 6.2 6 0 0 6 6 6 4 HEAT repeat Pkinase_Tyr PF07714.17 ORX62898.1 - 1.3e-08 34.5 0.0 4e-08 32.9 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase HEAT_2 PF13646.6 ORX62898.1 - 3.1e-08 33.9 0.3 0.052 13.9 0.1 4.8 3 2 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 ORX62898.1 - 1.1e-05 25.8 1.9 0.021 15.3 0.3 4.5 4 0 0 4 4 4 1 HEAT-like repeat Tti2 PF10521.9 ORX62898.1 - 0.0018 17.8 0.0 0.0048 16.5 0.0 1.6 1 0 0 1 1 1 1 Tti2 family Cnd1 PF12717.7 ORX62898.1 - 0.017 15.2 8.2 13 5.8 0.0 4.9 2 2 2 5 5 5 0 non-SMC mitotic condensation complex subunit 1 CPSF_A PF03178.15 ORX62898.1 - 0.1 11.9 0.1 0.18 11.0 0.1 1.3 1 0 0 1 1 1 0 CPSF A subunit region RTP1_C1 PF10363.9 ORX62898.1 - 0.22 11.7 0.7 3.3 7.9 0.0 2.9 3 0 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Carboxyl_trans PF01039.22 ORX62899.1 - 1.4e-147 492.3 0.0 1.8e-147 492.0 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ORX62899.1 - 0.084 12.3 0.0 8.5 5.8 0.0 2.2 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Pet191_N PF10203.9 ORX62900.1 - 4.1e-26 91.1 6.1 4.4e-26 91.0 6.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Cmc1 PF08583.10 ORX62900.1 - 0.29 11.2 7.0 4.4 7.4 0.5 2.6 1 1 2 3 3 3 0 Cytochrome c oxidase biogenesis protein Cmc1 like UQ_con PF00179.26 ORX62901.1 - 3.4e-51 172.6 0.0 3.8e-51 172.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ORX62901.1 - 0.0025 17.5 0.0 0.0031 17.2 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ORX62901.1 - 0.017 15.4 0.0 0.023 15.0 0.0 1.3 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 ORX62901.1 - 0.077 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 UEV domain Ribosomal_L7Ae PF01248.26 ORX62902.1 - 1.8e-26 91.7 0.0 2.2e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Ribosomal_S6e PF01092.19 ORX62905.1 - 1.7e-61 205.7 1.2 3.9e-61 204.6 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S6e TRAPP PF04051.16 ORX62906.1 - 5.3e-28 97.6 0.0 6e-28 97.4 0.0 1.0 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component TRAPP PF04051.16 ORX62907.1 - 0.00041 20.1 0.0 0.0023 17.6 0.1 2.2 2 1 0 2 2 2 1 Transport protein particle (TRAPP) component PMT_2 PF13231.6 ORX62907.1 - 0.016 15.4 2.9 0.016 15.4 2.9 2.5 2 1 0 2 2 2 0 Dolichyl-phosphate-mannose-protein mannosyltransferase GWT1 PF06423.12 ORX62907.1 - 0.02 15.0 0.3 0.036 14.2 0.3 1.6 1 0 0 1 1 1 0 GWT1 DUF202 PF02656.15 ORX62907.1 - 2.6 8.6 9.6 2.8 8.5 1.7 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF202) MTS PF05175.14 ORX62908.1 - 6.5e-10 38.8 0.0 9.8e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ORX62908.1 - 6.9e-10 39.5 0.0 1.1e-09 38.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX62908.1 - 1.2e-09 38.2 0.0 1.7e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 ORX62908.1 - 2e-08 33.9 0.0 2.5e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 ORX62908.1 - 3e-07 30.1 0.0 4.6e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ORX62908.1 - 6.2e-06 26.0 0.0 9.2e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_23 PF13489.6 ORX62908.1 - 1.7e-05 24.8 0.0 4.9e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX62908.1 - 4.1e-05 24.3 0.0 0.00011 22.9 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain PrmC_N PF17827.1 ORX62908.1 - 0.00011 22.6 0.3 0.00042 20.9 0.0 2.1 2 1 0 2 2 2 1 PrmC N-terminal domain Methyltransf_11 PF08241.12 ORX62908.1 - 0.00045 20.8 0.0 0.00076 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ORX62908.1 - 0.00068 19.4 0.0 0.0012 18.6 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_10 PF05971.12 ORX62908.1 - 0.0011 18.4 0.0 0.0018 17.7 0.0 1.3 1 0 0 1 1 1 1 RNA methyltransferase AviRa PF11599.8 ORX62908.1 - 0.0014 18.1 0.1 0.0052 16.3 0.0 1.9 2 0 0 2 2 2 1 RRNA methyltransferase AviRa Methyltransf_32 PF13679.6 ORX62908.1 - 0.0015 18.6 0.0 0.0019 18.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX62908.1 - 0.0065 15.8 0.0 0.0089 15.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltrans_SAM PF10672.9 ORX62908.1 - 0.0072 15.5 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 S-adenosylmethionine-dependent methyltransferase 3HCDH_N PF02737.18 ORX62908.1 - 0.0097 15.8 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ORX62908.1 - 0.011 15.4 0.0 0.017 14.7 0.0 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain PCMT PF01135.19 ORX62908.1 - 0.011 15.5 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_16 PF10294.9 ORX62908.1 - 0.014 15.1 0.0 0.064 13.0 0.0 2.0 2 0 0 2 2 2 0 Lysine methyltransferase GidB PF02527.15 ORX62908.1 - 0.12 11.7 0.0 0.38 10.1 0.0 1.8 2 1 0 2 2 2 0 rRNA small subunit methyltransferase G YdjO PF14169.6 ORX62910.1 - 0.13 12.0 1.9 0.31 10.8 1.9 1.6 1 0 0 1 1 1 0 Cold-inducible protein YdjO zf-C3HC4_4 PF15227.6 ORX62910.1 - 0.2 11.9 2.4 0.31 11.2 1.2 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Thioredox_DsbH PF03190.15 ORX62911.1 - 7.3e-76 253.7 0.0 1.4e-75 252.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Thioredoxin_7 PF13899.6 ORX62911.1 - 3.1e-10 40.1 0.0 7.9e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 Thioredoxin-like Glyco_hydro_127 PF07944.12 ORX62911.1 - 0.0012 17.5 0.0 0.12 10.8 0.0 2.2 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Thioredoxin_2 PF13098.6 ORX62911.1 - 0.0072 16.8 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain Soyouz_module PF14313.6 ORX62911.1 - 0.033 14.0 0.0 7.8 6.4 0.0 3.0 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) C5-epim_C PF06662.13 ORX62911.1 - 0.041 13.4 0.0 0.13 11.8 0.0 1.9 1 0 0 1 1 1 0 D-glucuronyl C5-epimerase C-terminus eIF3m_C_helix PF18005.1 ORX62912.1 - 8.8e-15 54.1 3.0 2e-14 53.0 1.7 2.3 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix PCI PF01399.27 ORX62912.1 - 1.2e-10 41.8 0.8 5.3e-10 39.7 0.0 2.5 3 0 0 3 3 3 1 PCI domain TPR_20 PF14561.6 ORX62912.1 - 0.022 15.1 1.4 1.4 9.3 0.8 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat FliD_N PF02465.18 ORX62912.1 - 0.28 11.9 4.0 3.5 8.4 0.2 3.3 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Transmemb_17 PF09799.9 ORX62913.1 - 0.017 15.7 10.5 0.017 15.7 10.5 3.6 4 1 0 4 4 4 0 Predicted membrane protein BTB_2 PF02214.22 ORX62915.1 - 2.6e-19 69.3 0.1 7.8e-19 67.8 0.0 1.8 2 0 0 2 2 2 1 BTB/POZ domain HIP1_clath_bdg PF16515.5 ORX62915.1 - 0.039 14.6 2.1 0.065 13.9 2.1 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RhoGAP PF00620.27 ORX62916.1 - 1.6e-29 102.7 0.0 6.1e-29 100.8 0.0 2.0 2 0 0 2 2 2 1 RhoGAP domain MyTH4 PF00784.17 ORX62916.1 - 2.9e-23 82.4 0.1 8.1e-23 81.0 0.0 1.8 2 0 0 2 2 2 1 MyTH4 domain WW PF00397.26 ORX62916.1 - 2.7e-09 37.0 3.8 0.0019 18.2 0.0 2.5 2 0 0 2 2 2 2 WW domain HSP70 PF00012.20 ORX62917.1 - 5.8e-06 24.8 0.0 9.6e-06 24.1 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ORX62917.1 - 0.069 11.9 0.0 0.31 9.8 0.0 1.8 2 0 0 2 2 2 0 MreB/Mbl protein cNMP_binding PF00027.29 ORX62918.1 - 1.6e-42 143.5 0.1 6e-21 74.3 0.0 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 ORX62918.1 - 3.9e-11 42.4 0.2 7.2e-11 41.6 0.2 1.4 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit Kelch_4 PF13418.6 ORX62920.1 - 1.5e-11 44.1 4.5 0.0067 16.4 0.0 5.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ORX62920.1 - 2e-09 37.5 13.4 0.00018 21.7 0.2 5.9 5 1 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX62920.1 - 1.6e-07 31.2 0.5 0.24 11.4 0.0 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ORX62920.1 - 2.5e-06 27.5 4.8 0.08 13.3 0.0 5.3 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ORX62920.1 - 2e-05 24.1 0.1 0.5 10.0 0.0 4.5 5 0 0 5 5 5 2 Kelch motif DUF4574 PF15141.6 ORX62920.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 BAR_2 PF10455.9 ORX62921.1 - 2.7e-57 194.1 1.5 3.8e-57 193.6 1.5 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 ORX62921.1 - 1.1e-23 84.1 6.8 6e-23 81.7 6.8 1.9 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 ORX62921.1 - 2.7e-07 30.6 4.3 1.6e-06 28.0 0.8 2.6 2 1 0 2 2 2 1 BAR domain of APPL family Vps5 PF09325.10 ORX62921.1 - 0.046 13.3 3.1 1.5 8.3 0.0 3.1 2 1 0 3 3 3 0 Vps5 C terminal like SBP_bac_3 PF00497.20 ORX62921.1 - 0.19 11.1 1.8 0.21 11.0 0.4 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 3 Ufd2P_core PF10408.9 ORX62921.1 - 0.27 9.8 4.4 0.063 11.9 0.7 1.7 2 0 0 2 2 2 0 Ubiquitin elongating factor core DUF2203 PF09969.9 ORX62921.1 - 2.6 8.8 9.5 60 4.4 0.6 3.9 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) zf-RING_2 PF13639.6 ORX62922.1 - 1e-08 35.3 6.8 3.2e-08 33.8 6.8 1.9 1 1 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ORX62922.1 - 2.6e-08 34.0 3.8 6e-08 32.9 3.8 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ORX62922.1 - 4.5e-07 29.7 2.3 1e-06 28.6 2.3 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ORX62922.1 - 2.2e-06 27.4 4.7 4.5e-06 26.4 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ORX62922.1 - 2.6e-06 27.2 4.0 2.6e-06 27.2 4.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX62922.1 - 0.00017 21.5 2.1 0.0002 21.3 0.7 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ORX62922.1 - 0.00019 21.4 3.4 0.00041 20.3 3.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2921 PF11145.8 ORX62922.1 - 0.00024 19.1 0.5 0.00051 18.0 0.3 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2921) Prok-RING_4 PF14447.6 ORX62922.1 - 0.00032 20.5 1.1 0.00032 20.5 1.1 1.6 2 0 0 2 2 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ORX62922.1 - 0.00038 20.2 4.0 0.00094 19.0 1.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ORX62922.1 - 0.0025 17.5 9.1 0.015 15.0 1.5 3.1 3 0 0 3 3 3 2 RING-like zinc finger Zn_ribbon_17 PF17120.5 ORX62922.1 - 0.007 16.0 5.7 0.079 12.6 5.7 2.2 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ORX62922.1 - 0.22 11.7 4.4 0.97 9.7 4.4 2.1 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ORX62922.1 - 1.1 9.4 5.7 2.7 8.2 5.7 1.7 1 1 0 1 1 1 0 RING-variant domain Metallophos PF00149.28 ORX62924.1 - 5.7e-37 128.2 0.4 7.9e-37 127.8 0.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX62924.1 - 0.00076 19.9 0.1 0.0014 19.0 0.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain SNF2_N PF00176.23 ORX62925.1 - 1e-72 244.8 0.1 1e-72 244.8 0.1 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Bromodomain PF00439.25 ORX62925.1 - 2.5e-22 78.7 0.6 9.8e-22 76.8 0.6 2.1 1 0 0 1 1 1 1 Bromodomain Helicase_C PF00271.31 ORX62925.1 - 4.8e-22 78.4 0.2 1e-20 74.1 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 ORX62925.1 - 2.2e-16 59.9 7.0 2.2e-16 59.9 7.0 3.3 3 0 0 3 3 3 1 HSA QLQ PF08880.11 ORX62925.1 - 2.6e-16 59.1 2.8 7.3e-16 57.6 2.8 1.9 1 0 0 1 1 1 1 QLQ SnAC PF14619.6 ORX62925.1 - 7.9e-14 52.0 3.5 7.9e-14 52.0 3.5 3.8 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex ResIII PF04851.15 ORX62925.1 - 6.4e-10 39.3 0.3 3.1e-09 37.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ORX62925.1 - 0.00039 20.2 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.6 ORX62925.1 - 0.14 12.2 0.4 1.6 8.8 0.0 2.9 3 0 0 3 3 3 0 AAA domain CorA PF01544.18 ORX62925.1 - 5 6.3 7.2 11 5.2 7.2 1.6 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein FF PF01846.19 ORX62927.1 - 5.2e-33 113.0 19.1 1.2e-12 47.8 0.4 3.3 3 0 0 3 3 3 3 FF domain WW PF00397.26 ORX62927.1 - 5.3e-13 48.8 14.2 6.8e-10 38.9 4.5 3.0 3 0 0 3 3 3 2 WW domain RhoGAP-FF1 PF16512.5 ORX62927.1 - 0.0074 16.9 7.0 0.12 13.1 0.4 3.2 2 1 1 3 3 3 2 p190-A and -B Rho GAPs FF domain DUF87 PF01935.17 ORX62927.1 - 1.2 9.1 2.9 2.1 8.4 2.9 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain Proteasome PF00227.26 ORX62928.1 - 1.7e-45 154.9 0.0 1.9e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Asp PF00026.23 ORX62928.1 - 0.15 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic aspartyl protease F-box-like PF12937.7 ORX62929.1 - 5.5e-05 23.0 1.4 0.00012 21.8 1.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62929.1 - 0.00054 19.8 0.2 0.0015 18.4 0.2 1.8 1 0 0 1 1 1 1 F-box domain LRR_4 PF12799.7 ORX62929.1 - 0.29 11.6 8.0 0.39 11.2 0.1 4.6 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) RALF PF05498.11 ORX62930.1 - 0.025 15.5 0.1 0.047 14.7 0.1 1.5 1 0 0 1 1 1 0 Rapid ALkalinization Factor (RALF) AKAP7_NLS PF10469.9 ORX62931.1 - 0.042 13.8 0.0 0.044 13.7 0.0 1.1 1 0 0 1 1 1 0 AKAP7 2'5' RNA ligase-like domain AKAP7_NLS PF10469.9 ORX62932.1 - 2.4e-08 34.1 0.0 2.6e-08 34.0 0.0 1.1 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ORX62932.1 - 0.01 15.7 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily Bac_rhamnosid PF05592.11 ORX62932.1 - 0.042 13.8 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase concanavalin-like domain F-box-like PF12937.7 ORX62934.1 - 0.00021 21.1 1.0 0.00075 19.4 1.0 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62934.1 - 0.0015 18.4 0.0 0.0048 16.7 0.0 1.9 1 0 0 1 1 1 1 F-box domain F-box PF00646.33 ORX62935.1 - 0.00019 21.2 2.7 0.00038 20.3 0.3 3.0 3 0 0 3 3 3 1 F-box domain F-box-like PF12937.7 ORX62935.1 - 0.0015 18.4 1.9 0.005 16.7 1.9 2.0 1 0 0 1 1 1 1 F-box-like Sigma70_r4_2 PF08281.12 ORX62935.1 - 0.0047 16.6 0.1 0.014 15.1 0.0 1.9 2 0 0 2 2 2 1 Sigma-70, region 4 LRR_4 PF12799.7 ORX62935.1 - 0.2 12.1 16.4 42 4.7 0.9 7.0 5 2 2 7 7 7 0 Leucine Rich repeats (2 copies) F-box-like PF12937.7 ORX62936.1 - 2e-05 24.4 0.7 7.9e-05 22.5 0.7 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62936.1 - 0.003 17.4 0.3 0.011 15.6 0.3 2.0 1 0 0 1 1 1 1 F-box domain Peroxidase_ext PF11895.8 ORX62936.1 - 0.037 13.9 0.0 0.11 12.4 0.0 1.8 1 0 0 1 1 1 0 Fungal peroxidase extension region UAA PF08449.11 ORX62937.1 - 1.4e-10 40.9 18.3 1.6e-10 40.7 18.3 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ORX62937.1 - 2e-06 28.0 23.7 2.7e-06 27.6 8.1 2.1 2 0 0 2 2 2 2 EamA-like transporter family HisKA_4TM PF16926.5 ORX62937.1 - 0.052 13.1 2.4 1.4 8.5 2.4 2.6 1 1 0 1 1 1 0 Archaeal 4TM region of histidine kinase Multi_Drug_Res PF00893.19 ORX62937.1 - 0.068 13.8 12.1 0.36 11.5 4.6 2.6 2 0 0 2 2 2 0 Small Multidrug Resistance protein Peptidase_C1_2 PF03051.15 ORX62937.1 - 0.081 11.7 0.5 0.68 8.6 0.0 2.0 2 0 0 2 2 2 0 Peptidase C1-like family SNO PF01174.19 ORX62938.1 - 2.6e-56 190.5 0.0 3e-56 190.3 0.0 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 ORX62938.1 - 7.1e-11 42.1 0.0 2.8e-10 40.1 0.0 1.7 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 ORX62938.1 - 0.00015 21.6 0.0 0.00028 20.7 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_S51 PF03575.17 ORX62938.1 - 0.00088 19.0 0.0 0.0014 18.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.24 ORX62938.1 - 0.0023 17.8 0.0 0.0041 16.9 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family DUF2219 PF09982.9 ORX62938.1 - 0.15 11.3 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2219) Ribosomal_L32e PF01655.18 ORX62939.1 - 2.4e-52 175.9 0.7 2.9e-52 175.6 0.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Sel1 PF08238.12 ORX62940.1 - 1.1e-102 334.1 116.1 1.7e-07 31.7 0.7 31.9 33 0 0 33 33 33 23 Sel1 repeat TPR_16 PF13432.6 ORX62940.1 - 0.013 16.2 2.2 0.013 16.2 2.2 13.2 12 1 1 13 13 13 0 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62940.1 - 0.028 14.7 0.5 0.028 14.7 0.5 12.6 12 3 1 13 13 13 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62940.1 - 0.033 14.2 25.0 1.1 9.5 0.3 9.5 11 0 0 11 11 11 0 Tetratricopeptide repeat WWE PF02825.20 ORX62941.1 - 0.00055 20.5 0.1 0.032 14.8 0.0 2.3 2 0 0 2 2 2 2 WWE domain MBOAT PF03062.19 ORX62945.1 - 2.5e-49 168.5 26.8 2.5e-49 168.5 26.8 1.7 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family WH1 PF00568.23 ORX62946.1 - 1.3e-23 83.0 0.0 2.9e-23 81.9 0.0 1.5 2 0 0 2 2 2 1 WH1 domain PBD PF00786.28 ORX62946.1 - 3.6e-08 33.6 0.5 1.3e-07 31.9 0.1 2.0 2 0 0 2 2 2 1 P21-Rho-binding domain DCP1 PF06058.13 ORX62946.1 - 0.14 12.0 0.1 0.28 11.1 0.0 1.4 2 0 0 2 2 2 0 Dcp1-like decapping family CAP_N PF01213.19 ORX62946.1 - 0.15 11.5 8.5 0.22 11.0 8.5 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 ORX62946.1 - 0.72 9.9 7.1 1.1 9.2 7.1 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Sel1 PF08238.12 ORX62947.1 - 3.9e-42 141.7 20.8 4.5e-07 30.3 0.1 7.2 7 0 0 7 7 7 7 Sel1 repeat TPR_1 PF00515.28 ORX62947.1 - 0.022 14.6 1.0 31 4.6 0.1 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62947.1 - 0.11 13.2 7.9 5.1 8.0 0.2 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62947.1 - 0.28 11.4 8.7 19 5.6 0.0 6.0 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62947.1 - 0.31 10.8 10.1 1.1 9.0 0.0 4.7 5 1 1 6 6 6 0 TPR repeat Hist_deacetyl PF00850.19 ORX62948.1 - 4.4e-84 282.6 0.0 5.7e-84 282.2 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Formin_GBD_N PF18382.1 ORX62948.1 - 0.14 12.6 0.6 3 8.4 0.0 2.4 2 0 0 2 2 2 0 Formin N-terminal GTPase-binding domain DNA_pol_A_exo1 PF01612.20 ORX62949.1 - 1.5e-16 60.6 0.6 2.8e-16 59.7 0.6 1.4 1 0 0 1 1 1 1 3'-5' exonuclease ABC2_membrane PF01061.24 ORX62950.1 - 4.5e-79 264.7 58.9 5.3e-43 146.9 21.2 3.1 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 ORX62950.1 - 1e-32 113.5 0.7 8.1e-18 65.3 0.0 3.3 4 0 0 4 4 3 2 ABC transporter PDR_CDR PF06422.12 ORX62950.1 - 1.6e-25 88.8 11.6 2e-20 72.4 0.0 3.3 3 0 0 3 3 2 2 CDR ABC transporter ABC_trans_N PF14510.6 ORX62950.1 - 8.6e-11 42.3 0.1 2.1e-10 41.1 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 ORX62950.1 - 2.3e-06 27.0 44.0 0.0012 18.0 22.7 2.8 2 1 0 2 2 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 ORX62950.1 - 4.8e-06 26.6 0.0 0.0029 17.5 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ORX62950.1 - 8e-06 26.3 0.0 0.0049 17.3 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain AAA_21 PF13304.6 ORX62950.1 - 0.00012 22.0 0.0 0.47 10.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ORX62950.1 - 0.0038 16.9 0.6 0.022 14.5 0.2 2.3 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 ORX62950.1 - 0.0054 16.3 0.0 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ORX62950.1 - 0.0069 16.7 0.0 1.2 9.4 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 ORX62950.1 - 0.014 15.1 0.0 1.1 9.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ORX62950.1 - 0.02 15.5 0.0 0.36 11.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 ORX62950.1 - 0.03 13.9 0.2 1.3 8.6 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC2_membrane_2 PF12679.7 ORX62950.1 - 0.044 13.1 12.3 0.63 9.3 1.1 2.8 2 0 0 2 2 2 0 ABC-2 family transporter protein Zeta_toxin PF06414.12 ORX62950.1 - 0.05 12.9 0.0 0.75 9.0 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin AAA PF00004.29 ORX62950.1 - 0.059 13.8 0.0 9.9 6.6 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ORX62950.1 - 0.14 12.6 0.0 0.49 10.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ORX62950.1 - 0.15 12.2 0.0 0.76 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF1440 PF07274.12 ORX62950.1 - 0.2 12.0 3.3 0.81 10.0 3.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1440) PDR_assoc PF08370.11 ORX62950.1 - 4.9 7.0 10.1 4.4 7.1 0.2 3.3 3 0 0 3 3 3 0 Plant PDR ABC transporter associated HAP1_N PF04849.13 ORX62951.1 - 0.00011 21.5 21.6 0.0012 18.1 11.5 3.4 1 1 2 3 3 3 2 HAP1 N-terminal conserved region Spc7 PF08317.11 ORX62951.1 - 0.00089 18.2 12.4 0.00089 18.2 12.4 2.4 1 1 1 2 2 2 2 Spc7 kinetochore protein ATG16 PF08614.11 ORX62951.1 - 0.00099 19.4 11.0 0.00099 19.4 11.0 3.0 2 1 1 3 3 3 1 Autophagy protein 16 (ATG16) Activator-TraM PF11657.8 ORX62951.1 - 0.011 15.6 2.6 0.028 14.3 2.6 1.7 1 0 0 1 1 1 0 Transcriptional activator TraM Synaptonemal_3 PF15191.6 ORX62951.1 - 0.011 15.5 1.8 0.017 14.8 0.4 2.1 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 MscS_porin PF12795.7 ORX62951.1 - 0.012 15.2 31.5 0.048 13.2 16.9 2.6 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain HK97-gp10_like PF04883.12 ORX62951.1 - 0.049 14.6 0.0 0.14 13.2 0.0 1.9 1 1 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component ADIP PF11559.8 ORX62951.1 - 0.05 13.7 25.9 0.027 14.5 7.3 3.6 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding AAA_13 PF13166.6 ORX62951.1 - 0.052 12.2 16.1 0.24 10.0 14.6 2.3 2 1 0 2 2 2 0 AAA domain DUF489 PF04356.12 ORX62951.1 - 0.12 12.4 6.9 0.071 13.1 3.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF489) DUF4201 PF13870.6 ORX62951.1 - 0.15 11.8 14.3 0.075 12.8 2.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF2935 PF11155.8 ORX62951.1 - 0.16 12.3 2.4 2.1 8.7 2.4 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) ERM PF00769.19 ORX62951.1 - 0.24 11.2 23.8 0.44 10.3 4.2 2.4 1 1 0 2 2 2 0 Ezrin/radixin/moesin family APG6_N PF17675.1 ORX62951.1 - 0.37 11.3 25.6 0.23 12.0 10.5 3.1 1 1 3 4 4 4 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ORX62951.1 - 0.52 10.3 29.3 2.1 8.4 6.7 3.7 1 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ORX62951.1 - 0.58 9.5 22.7 0.029 13.7 11.7 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 ORX62951.1 - 0.58 10.4 25.8 1.3 9.2 3.4 4.0 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding Nnf1 PF03980.14 ORX62951.1 - 1.1 9.7 15.2 4.6 7.7 3.5 3.9 2 1 1 3 3 3 0 Nnf1 FapA PF03961.13 ORX62951.1 - 1.5 7.4 13.2 2 6.9 0.4 2.5 1 1 1 3 3 3 0 Flagellar Assembly Protein A TACC_C PF05010.14 ORX62951.1 - 1.8 8.3 18.8 0.85 9.4 10.3 2.6 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ABC_tran_CTD PF16326.5 ORX62951.1 - 1.9 8.8 17.3 6.4 7.1 2.7 4.2 1 1 3 4 4 4 0 ABC transporter C-terminal domain TSC22 PF01166.18 ORX62951.1 - 2.6 8.4 9.4 9.1 6.7 0.2 3.8 3 0 0 3 3 3 0 TSC-22/dip/bun family PDR_CDR PF06422.12 ORX62953.1 - 0.21 11.5 1.2 0.46 10.4 0.2 2.0 2 0 0 2 2 2 0 CDR ABC transporter MutS_V PF00488.21 ORX62954.1 - 1.1e-81 273.3 0.1 1.8e-81 272.7 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX62954.1 - 5.2e-38 131.2 2.6 5.2e-38 131.2 2.6 2.0 2 0 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ORX62954.1 - 1.7e-17 64.0 0.2 6.9e-17 62.0 0.0 2.2 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ORX62954.1 - 4.4e-16 59.0 3.9 5.1e-16 58.8 0.5 2.5 2 0 0 2 2 2 1 MutS family domain IV MutS_I PF01624.20 ORX62954.1 - 4.8e-08 33.2 0.0 1e-07 32.2 0.0 1.6 1 0 0 1 1 1 1 MutS domain I Mating_N PF12731.7 ORX62954.1 - 0.23 11.6 1.2 4.5 7.4 0.1 3.1 3 0 0 3 3 3 0 Mating-type protein beta 1 Spectrin PF00435.21 ORX62954.1 - 0.57 10.7 8.8 19 5.8 0.0 3.8 3 0 0 3 3 3 0 Spectrin repeat ERG4_ERG24 PF01222.17 ORX62955.1 - 2.9e-156 520.6 11.7 3.3e-156 520.4 11.7 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ORX62955.1 - 7.6e-05 22.3 0.6 0.00025 20.6 0.6 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) DnaJ PF00226.31 ORX62956.1 - 1.5e-22 79.5 0.7 2.8e-22 78.6 0.7 1.5 1 0 0 1 1 1 1 DnaJ domain COX7a PF02238.15 ORX62957.1 - 1.4e-18 67.0 0.1 1.7e-18 66.8 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Crr6 PF08847.11 ORX62958.1 - 0.011 15.4 0.0 0.012 15.2 0.0 1.1 1 0 0 1 1 1 0 Chlororespiratory reduction 6 Acyl-CoA_dh_1 PF00441.24 ORX62960.1 - 6.5e-34 117.3 1.5 1e-33 116.6 1.5 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 ORX62960.1 - 1.4e-20 73.2 0.0 3.7e-20 71.8 0.0 1.8 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 ORX62960.1 - 6e-17 61.6 0.1 1.1e-16 60.8 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 ORX62960.1 - 3.2e-08 34.2 0.1 1.3e-07 32.3 0.0 2.2 2 1 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ORX62960.1 - 3.9e-07 30.4 0.0 8.3e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain WD40 PF00400.32 ORX62961.1 - 6.5e-06 26.8 2.0 0.52 11.3 0.0 4.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62961.1 - 0.029 14.7 0.1 1.9 8.8 0.0 3.4 3 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain G-alpha PF00503.20 ORX62962.1 - 3.2e-109 365.3 0.1 3.9e-109 365.1 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX62962.1 - 1.6e-14 53.7 0.4 5.7e-10 38.9 0.2 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ORX62962.1 - 0.0016 18.7 0.5 2.8 8.2 0.0 2.8 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX62962.1 - 0.005 16.2 0.1 0.34 10.2 0.1 2.3 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ORX62962.1 - 0.039 14.0 0.0 8.4 6.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase RNA_pol_Rpb2_6 PF00562.28 ORX62963.1 - 2.5e-124 415.3 0.4 4.3e-124 414.5 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 ORX62963.1 - 1.6e-59 200.9 0.6 2.4e-59 200.3 0.6 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 ORX62963.1 - 1.5e-34 118.2 0.6 4.5e-34 116.7 0.6 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 ORX62963.1 - 1e-32 113.3 3.5 1e-32 113.3 3.5 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 ORX62963.1 - 9.5e-23 80.3 3.7 2.3e-22 79.1 3.1 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 ORX62963.1 - 2.8e-21 75.5 0.1 9.6e-21 73.7 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 ORX62963.1 - 3.3e-10 40.4 0.4 1e-09 38.8 0.4 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DHHC PF01529.20 ORX62964.1 - 4.4e-36 124.0 6.8 6.6e-36 123.4 6.8 1.2 1 0 0 1 1 1 1 DHHC palmitoyltransferase Spt4 PF06093.13 ORX62964.1 - 4.1 7.6 8.4 4.9 7.3 6.6 1.9 2 0 0 2 2 2 0 Spt4/RpoE2 zinc finger Cys_Met_Meta_PP PF01053.20 ORX62965.1 - 1.4e-142 474.7 0.0 1.6e-142 474.5 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DegT_DnrJ_EryC1 PF01041.17 ORX62965.1 - 1.8e-12 47.3 0.1 7.3e-12 45.3 0.1 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 ORX62965.1 - 1.8e-10 40.5 0.0 3.5e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ORX62965.1 - 2.6e-07 30.0 0.1 3.8e-07 29.4 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Asparaginase_C PF17763.1 ORX62965.1 - 0.0018 18.5 0.0 0.045 14.0 0.0 2.8 3 0 0 3 3 3 1 Glutaminase/Asparaginase C-terminal domain GDC-P PF02347.16 ORX62965.1 - 0.0054 15.6 0.0 0.0082 15.0 0.0 1.2 1 0 0 1 1 1 1 Glycine cleavage system P-protein Met_gamma_lyase PF06838.11 ORX62965.1 - 0.011 14.3 0.0 0.013 14.0 0.0 1.2 1 0 0 1 1 1 0 Methionine gamma-lyase Beta_elim_lyase PF01212.21 ORX62965.1 - 0.044 13.0 0.0 0.12 11.7 0.0 1.6 1 1 0 1 1 1 0 Beta-eliminating lyase S1 PF00575.23 ORX62966.1 - 1.4e-52 175.9 14.3 1.9e-09 37.7 0.3 10.6 10 1 0 10 10 10 7 S1 RNA binding domain TPR_15 PF13429.6 ORX62966.1 - 3.8e-07 29.6 1.0 1.6e-05 24.3 0.2 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62966.1 - 5.8e-07 29.9 0.0 0.0013 19.1 0.0 3.6 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62966.1 - 8.2e-07 29.3 0.1 0.023 15.5 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat Suf PF05843.14 ORX62966.1 - 2.1e-06 28.0 0.3 2.1e-06 28.0 0.3 4.6 3 1 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_16 PF13432.6 ORX62966.1 - 1.4e-05 25.7 0.0 9.8e-05 22.9 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62966.1 - 0.00013 22.1 0.1 0.012 15.8 0.0 1.9 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ORX62966.1 - 0.00031 20.6 0.5 0.041 14.0 0.0 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62966.1 - 0.00033 20.9 0.3 0.0034 17.6 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ORX62966.1 - 0.0074 16.6 0.0 0.19 12.2 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62966.1 - 0.01 16.0 0.1 0.99 9.8 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ORX62966.1 - 0.017 14.9 0.0 0.87 9.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ORX62966.1 - 0.019 14.1 7.0 0.04 13.0 3.3 2.9 1 1 1 2 2 2 0 NRDE-2, necessary for RNA interference TPR_10 PF13374.6 ORX62966.1 - 0.042 13.7 0.6 0.58 10.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62966.1 - 0.086 13.5 0.7 19 6.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat OapA PF04225.12 ORX62966.1 - 0.13 12.4 0.1 0.77 9.9 0.0 2.4 2 0 0 2 2 1 0 Opacity-associated protein A LysM-like domain PTAC PF06130.12 ORX62966.1 - 1.3 9.2 3.4 9.9 6.4 0.1 3.3 3 0 0 3 3 2 0 Phosphate propanoyltransferase VPS28 PF03997.12 ORX62967.1 - 1.6e-53 181.2 0.0 2.7e-53 180.5 0.0 1.3 1 1 0 1 1 1 1 VPS28 protein tRNA-synt_2b PF00587.25 ORX62968.1 - 3e-23 82.7 0.0 5.2e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 ORX62968.1 - 1.6e-10 41.1 1.1 2.4e-10 40.6 1.1 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain DUF5320 PF17253.2 ORX62968.1 - 0.02 16.0 2.0 21 6.3 2.3 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5320) pP_pnuc_1 PF18165.1 ORX62968.1 - 0.075 12.9 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Predicted pPIWI-associating nuclease FapA PF03961.13 ORX62968.1 - 0.42 9.2 1.4 0.62 8.6 1.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PRKG1_interact PF15898.5 ORX62968.1 - 0.77 10.7 5.3 1.5 9.7 5.3 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Sel1 PF08238.12 ORX62969.1 - 2.6e-40 136.0 19.1 2.7e-08 34.2 0.0 7.3 7 0 0 7 7 7 6 Sel1 repeat WH1 PF00568.23 ORX62970.1 - 2.7e-27 94.9 0.3 4.2e-27 94.3 0.3 1.2 1 0 0 1 1 1 1 WH1 domain PBD PF00786.28 ORX62970.1 - 3.6e-06 27.2 0.1 7.4e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 P21-Rho-binding domain WH2 PF02205.20 ORX62970.1 - 0.012 15.5 0.4 0.025 14.4 0.4 1.6 1 0 0 1 1 1 0 WH2 motif DUF2052 PF09747.9 ORX62971.1 - 2.9e-22 79.8 20.1 4e-20 72.8 20.1 2.1 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) MFS_1 PF07690.16 ORX62972.1 - 1.6e-13 50.3 34.9 1.6e-13 50.3 34.9 1.7 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.16 ORX62972.1 - 5.1e-13 49.0 5.7 5.1e-13 49.0 5.7 2.6 3 0 0 3 3 3 1 Ion channel regulatory protein UNC-93 TraD_N PF12615.8 ORX62972.1 - 1.9 9.3 8.7 1.4 9.7 0.7 3.3 2 0 0 2 2 2 0 F sex factor protein N terminal BRAP2 PF07576.12 ORX62973.1 - 1.2e-23 83.1 0.0 2.2e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ORX62973.1 - 1.2e-18 67.2 5.9 4.3e-18 65.4 5.9 1.9 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein SPX PF03105.19 ORX62973.1 - 1.8e-05 24.8 2.4 2.4e-05 24.5 2.4 1.1 1 0 0 1 1 1 1 SPX domain zf-RING_2 PF13639.6 ORX62973.1 - 0.00033 20.9 8.7 0.00033 20.9 8.7 2.7 2 0 0 2 2 2 1 Ring finger domain Filament PF00038.21 ORX62973.1 - 0.0066 16.1 7.0 0.27 10.8 0.9 2.1 2 0 0 2 2 2 2 Intermediate filament protein zf-RING_UBOX PF13445.6 ORX62973.1 - 0.012 15.6 6.7 0.012 15.6 6.7 2.7 2 0 0 2 2 1 0 RING-type zinc-finger UPF0242 PF06785.11 ORX62973.1 - 0.023 14.8 10.3 0.038 14.1 10.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ORX62973.1 - 0.025 13.5 6.5 0.041 12.8 6.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SOGA PF11365.8 ORX62973.1 - 0.039 15.1 5.1 2 9.6 2.8 2.4 1 1 1 2 2 2 0 Protein SOGA LPP PF04728.13 ORX62973.1 - 0.048 14.1 6.6 3.5 8.1 0.1 3.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper zf-C3HC4_3 PF13920.6 ORX62973.1 - 0.075 12.9 17.0 0.21 11.5 4.3 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ORX62973.1 - 0.12 12.7 5.2 0.49 10.7 5.2 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain DUF1631 PF07793.11 ORX62973.1 - 0.15 10.4 13.5 0.2 10.0 13.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Exonuc_VII_L PF02601.15 ORX62973.1 - 0.16 11.5 6.0 0.23 11.0 6.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ADIP PF11559.8 ORX62973.1 - 0.2 11.7 11.0 0.41 10.7 3.4 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 ORX62973.1 - 0.28 11.8 13.1 10 6.8 0.1 3.0 2 1 0 2 2 2 0 SlyX H-kinase_dim PF02895.14 ORX62973.1 - 0.28 11.6 1.8 2.5 8.6 1.7 2.3 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain HalX PF08663.10 ORX62973.1 - 0.39 11.1 4.0 3.8 7.9 0.5 2.7 2 0 0 2 2 2 0 HalX domain CENP-K PF11802.8 ORX62973.1 - 0.46 10.0 9.0 0.68 9.5 9.0 1.1 1 0 0 1 1 1 0 Centromere-associated protein K Suppressor_APC PF11414.8 ORX62973.1 - 0.58 10.3 4.4 9.5 6.4 0.3 2.4 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein DUF4407 PF14362.6 ORX62973.1 - 0.62 9.4 7.6 1.1 8.6 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TTKRSYEDQ PF10212.9 ORX62973.1 - 1.1 8.2 10.8 0.11 11.4 4.4 1.9 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein SHE3 PF17078.5 ORX62973.1 - 1.3 8.7 11.8 1.8 8.2 2.1 2.2 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Syntaxin-6_N PF09177.11 ORX62973.1 - 1.5 9.5 10.1 0.64 10.6 5.7 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal BLOC1_2 PF10046.9 ORX62973.1 - 1.6 9.1 6.7 3 8.2 0.3 2.6 3 0 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 ORX62973.1 - 1.9 8.3 8.6 0.96 9.3 1.0 2.9 2 1 1 3 3 3 0 Septum formation initiator FUSC PF04632.12 ORX62973.1 - 2 6.8 6.5 3 6.3 6.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Spc24 PF08286.11 ORX62973.1 - 2.1 8.7 11.0 4.7 7.5 2.4 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 CENP-F_leu_zip PF10473.9 ORX62973.1 - 2.1 8.4 11.1 3.4 7.7 5.8 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Phage_GP20 PF06810.11 ORX62973.1 - 4.7 7.0 9.7 16 5.3 0.2 2.8 1 1 1 3 3 3 0 Phage minor structural protein GP20 FapA PF03961.13 ORX62973.1 - 4.9 5.7 5.6 13 4.2 2.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A Snapin_Pallidin PF14712.6 ORX62973.1 - 7.1 7.1 14.0 9 6.8 6.8 2.6 2 1 0 2 2 2 0 Snapin/Pallidin zf-RING_11 PF17123.5 ORX62973.1 - 7.8 6.4 9.1 0.74 9.6 3.5 2.4 2 0 0 2 2 2 0 RING-like zinc finger Yippee-Mis18 PF03226.14 ORX62974.1 - 2.9e-14 53.1 1.5 3.4e-14 52.9 1.5 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF678 PF05077.12 ORX62974.1 - 0.0057 16.8 0.3 0.068 13.3 0.1 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF678) F-box-like PF12937.7 ORX62975.1 - 1.1e-06 28.5 0.7 3.9e-06 26.7 0.7 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX62975.1 - 0.013 15.3 0.1 0.032 14.1 0.1 1.6 1 0 0 1 1 1 0 F-box domain DUF1644 PF07800.12 ORX62976.1 - 0.0019 18.3 3.3 0.0035 17.4 3.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1644) NifQ PF04891.12 ORX62976.1 - 0.9 9.9 6.3 1.7 8.9 1.8 2.2 2 0 0 2 2 2 0 NifQ DUF1612 PF07756.12 ORX62977.1 - 0.00055 20.2 0.4 0.09 13.0 0.2 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1612) DUF728 PF05304.12 ORX62977.1 - 0.11 12.3 4.0 0.3 10.9 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF728) AAA PF00004.29 ORX62979.1 - 1.5e-55 187.2 0.1 6.8e-39 133.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ORX62979.1 - 1.8e-10 40.5 0.3 4.8e-10 39.1 0.3 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ORX62979.1 - 1.2e-09 38.6 0.3 0.0025 18.1 0.2 4.0 2 2 0 3 3 3 3 AAA domain AAA_16 PF13191.6 ORX62979.1 - 1.5e-08 35.2 0.0 0.0069 16.8 0.0 3.7 2 1 1 3 3 3 2 AAA ATPase domain AAA_24 PF13479.6 ORX62979.1 - 2.7e-07 30.5 0.0 0.032 14.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 ORX62979.1 - 3.4e-07 30.5 0.2 5.1e-05 23.4 0.1 3.3 2 1 1 3 3 3 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ORX62979.1 - 9.7e-07 28.7 0.2 0.0059 16.4 0.1 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ORX62979.1 - 1.7e-06 28.1 0.0 0.00066 19.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ORX62979.1 - 2.7e-06 26.9 0.1 0.0051 16.2 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ORX62979.1 - 4.2e-06 26.2 0.1 0.074 12.2 0.0 2.5 2 1 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 ORX62979.1 - 1.4e-05 25.3 0.0 0.25 11.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 ORX62979.1 - 6.8e-05 23.2 0.0 0.082 13.3 0.0 3.1 3 0 0 3 3 2 1 RNA helicase AAA_25 PF13481.6 ORX62979.1 - 7.9e-05 22.3 0.4 2.5 7.6 0.0 4.2 3 1 0 4 4 4 1 AAA domain AAA_18 PF13238.6 ORX62979.1 - 0.00012 22.6 0.0 0.01 16.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ORX62979.1 - 0.00018 21.5 0.9 17 5.3 0.0 4.2 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ORX62979.1 - 0.00036 20.6 0.0 1.2 9.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain ATPase PF06745.13 ORX62979.1 - 0.00048 19.5 0.1 0.044 13.1 0.0 3.3 2 1 1 3 3 3 1 KaiC IstB_IS21 PF01695.17 ORX62979.1 - 0.0011 18.8 0.0 0.098 12.4 0.0 3.0 2 1 1 3 3 3 1 IstB-like ATP binding protein TniB PF05621.11 ORX62979.1 - 0.0012 18.3 0.1 0.9 8.9 0.1 3.2 2 1 0 2 2 2 1 Bacterial TniB protein AAA_7 PF12775.7 ORX62979.1 - 0.0048 16.4 0.0 0.032 13.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region CDC48_2 PF02933.17 ORX62979.1 - 0.009 15.8 0.2 0.042 13.6 0.0 2.1 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_11 PF13086.6 ORX62979.1 - 0.011 15.6 0.0 0.34 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ORX62979.1 - 0.013 15.4 0.1 6.3 6.7 0.1 3.3 3 1 0 3 3 3 0 NACHT domain PPV_E1_C PF00519.17 ORX62979.1 - 0.028 13.2 0.1 1.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Papillomavirus helicase Parvo_NS1 PF01057.17 ORX62979.1 - 0.037 13.1 0.0 1.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 ORX62979.1 - 0.037 14.0 0.0 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ORX62979.1 - 0.041 14.4 0.2 1 9.9 0.1 3.0 2 1 0 2 2 2 0 ABC transporter KTI12 PF08433.10 ORX62979.1 - 0.058 12.8 0.0 3.8 6.9 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Sigma54_activat PF00158.26 ORX62979.1 - 0.059 13.1 0.0 2.2 7.9 0.1 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 ORX62979.1 - 0.13 12.1 0.0 0.39 10.6 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ORX62979.1 - 0.13 11.4 0.1 5.5 6.1 0.1 2.5 2 0 0 2 2 2 0 NB-ARC domain AAA_28 PF13521.6 ORX62979.1 - 0.19 12.0 0.0 2.8 8.1 0.0 2.5 3 0 0 3 3 2 0 AAA domain MutS_V PF00488.21 ORX62980.1 - 2.7e-40 138.4 0.1 4.8e-40 137.6 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ORX62980.1 - 7.9e-23 81.7 0.0 1.3e-22 81.0 0.0 1.3 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 ORX62980.1 - 0.0032 17.8 0.0 0.007 16.7 0.0 1.6 1 0 0 1 1 1 1 MutS family domain IV AAA_16 PF13191.6 ORX62980.1 - 0.15 12.4 0.0 0.42 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ORX62980.1 - 0.2 11.3 0.1 0.34 10.6 0.1 1.3 1 0 0 1 1 1 0 AAA domain Hep_core_N PF08290.11 ORX62980.1 - 2.9 8.0 6.8 33 4.6 0.9 3.4 3 0 0 3 3 3 0 Hepatitis core protein, putative zinc finger Pkinase PF00069.25 ORX62981.1 - 3.3e-25 88.9 0.0 5.2e-25 88.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX62981.1 - 9.1e-12 44.8 0.0 1.7e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX62981.1 - 1.1e-07 31.1 2.3 4.8e-07 28.9 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Pex14_N PF04695.13 ORX62981.1 - 0.026 15.2 3.6 0.049 14.3 3.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region OTU PF02338.19 ORX62983.1 - 1e-11 45.4 0.0 1.9e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ORX62983.1 - 0.00042 19.9 0.1 0.39 10.1 0.0 2.5 2 0 0 2 2 2 2 Peptidase C65 Otubain CUE PF02845.16 ORX62983.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 CUE domain OrfB_IS605 PF01385.19 ORX62983.1 - 9.4 6.5 9.8 0.8 9.9 1.7 2.8 3 0 0 3 3 3 0 Probable transposase ELL PF10390.9 ORX62984.1 - 0.16 11.5 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase II elongation factor ELL RELT PF12606.8 ORX62986.1 - 0.019 14.0 0.7 0.027 13.4 0.7 1.3 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 NUP50 PF08911.11 ORX62987.1 - 0.00016 22.2 0.0 0.00016 22.2 0.0 3.8 3 0 0 3 3 3 1 NUP50 (Nucleoporin 50 kDa) DUF743 PF05332.11 ORX62987.1 - 0.21 11.6 0.1 0.35 10.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF743) FlgD_ig PF13860.6 ORX62988.1 - 0.00045 20.0 5.5 6.2 6.8 0.2 5.7 1 1 1 3 3 3 2 FlgD Ig-like domain SKG6 PF08693.10 ORX62988.1 - 0.0018 17.7 1.9 0.0064 15.9 1.9 2.1 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TcfC PF16967.5 ORX62988.1 - 0.0045 16.5 3.6 59 3.3 0.0 5.4 2 1 4 6 6 6 2 E-set like domain WD40 PF00400.32 ORX62989.1 - 1.2e-38 130.3 15.0 3.1e-06 27.8 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX62989.1 - 6.5e-12 45.6 0.0 0.012 15.9 0.1 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX62989.1 - 0.0015 17.9 0.0 0.053 12.8 0.0 2.3 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ORX62989.1 - 0.006 15.3 0.3 0.6 8.7 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ORX62989.1 - 0.033 14.0 0.0 2.2 8.1 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A MFS_1 PF07690.16 ORX62990.1 - 2.3e-40 138.6 32.5 9.7e-40 136.6 27.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ORX62990.1 - 4.5e-10 39.0 19.7 2.1e-09 36.8 19.7 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter adh_short PF00106.25 ORX62991.1 - 1.3e-33 116.1 0.1 1.6e-33 115.8 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX62991.1 - 6.7e-24 84.7 0.0 1e-23 84.2 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX62991.1 - 0.0014 18.6 0.5 0.0055 16.6 0.5 2.2 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ORX62991.1 - 0.0017 17.4 0.1 0.017 14.1 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX62991.1 - 0.17 11.3 0.1 2.4 7.6 0.1 2.2 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family Sugar_tr PF00083.24 ORX62992.1 - 3.9e-44 151.2 25.5 3.7e-26 92.0 6.6 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX62992.1 - 8.8e-20 70.9 35.3 7.4e-10 38.3 16.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX62992.1 - 0.0017 17.0 24.8 0.0076 14.9 7.3 3.2 2 1 1 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 ORX62993.1 - 1.2e-46 159.6 24.7 1.9e-26 92.9 5.0 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ORX62993.1 - 1.3e-22 80.2 34.8 1.9e-12 46.8 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ORX62993.1 - 2.5e-07 29.6 14.7 1.3e-05 24.0 2.1 3.2 3 0 0 3 3 3 2 MFS/sugar transport protein TPR_1 PF00515.28 ORX62994.1 - 2.1e-18 65.3 11.6 0.00052 19.7 0.5 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ORX62994.1 - 1.9e-13 49.4 12.8 0.00093 19.1 0.6 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ORX62994.1 - 2.8e-12 46.1 16.4 0.0016 18.1 1.3 5.2 2 2 3 5 5 5 4 TPR repeat TPR_16 PF13432.6 ORX62994.1 - 1.1e-09 38.7 4.1 7.2e-05 23.4 0.0 4.1 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ORX62994.1 - 3.2e-09 36.3 6.2 0.92 9.9 0.0 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 ORX62994.1 - 4.1e-09 36.8 20.5 6.7e-08 32.9 2.6 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX62994.1 - 2.4e-08 34.1 12.6 0.046 14.5 0.1 6.0 2 2 3 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 ORX62994.1 - 8.6e-08 32.4 7.7 0.055 13.8 0.0 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ORX62994.1 - 6.1e-07 29.4 14.8 0.016 15.5 1.4 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ORX62994.1 - 5.1e-06 26.1 4.4 0.67 10.1 0.0 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ORX62994.1 - 0.00088 19.4 13.0 0.02 15.0 0.5 4.3 3 2 2 5 5 5 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ORX62994.1 - 0.001 19.2 2.1 0.001 19.2 2.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ORX62994.1 - 0.0014 18.9 0.7 0.0014 18.9 0.7 4.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ORX62994.1 - 0.01 16.5 4.6 6 7.7 0.5 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ORX62994.1 - 0.012 15.6 1.1 27 4.9 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4248 PF14053.6 ORX62994.1 - 0.037 14.0 0.3 0.14 12.2 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) DSPc PF00782.20 ORX62995.1 - 2.5e-23 82.3 0.0 5e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ORX62995.1 - 3.8e-05 24.2 0.1 0.017 15.6 0.0 3.1 2 1 0 2 2 2 1 Rhodanese-like domain Y_phosphatase2 PF03162.13 ORX62995.1 - 0.0041 16.7 0.1 0.0079 15.8 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Init_tRNA_PT PF04179.12 ORX62995.1 - 0.0061 16.8 0.0 0.017 15.4 0.0 1.7 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ORX62995.1 - 0.055 13.0 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase EI24 PF07264.11 ORX62996.1 - 3.9e-19 69.6 26.6 5e-19 69.2 26.6 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) Tetraspanin PF00335.20 ORX62997.1 - 9.6e-15 54.9 16.1 1.3e-14 54.4 16.1 1.2 1 0 0 1 1 1 1 Tetraspanin family Gln-synt_C PF00120.24 ORX62998.1 - 1.4e-19 70.3 0.0 3.8e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ORX62998.1 - 8.7e-09 35.0 0.0 1.5e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain TssR PF17643.1 ORX63000.1 - 0.17 9.8 0.0 0.19 9.6 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR Transket_pyr PF02779.24 ORX63001.1 - 2.7e-63 212.9 0.0 4.3e-63 212.2 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ORX63001.1 - 3.4e-61 206.8 0.0 4.6e-61 206.4 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ORX63001.1 - 9e-57 191.0 0.1 1.6e-56 190.3 0.1 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 ORX63001.1 - 8.3e-19 66.9 1.4 9.9e-19 66.7 0.1 1.8 2 0 0 2 2 2 1 2-oxoglutarate dehydrogenase N-terminus R2K_2 PF18299.1 ORX63001.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 ATG101 PF07855.12 ORX63002.1 - 2.6e-21 76.2 0.3 3.6e-21 75.8 0.3 1.2 1 0 0 1 1 1 1 Autophagy-related protein 101 MoCF_biosynth PF00994.24 ORX63003.1 - 1.9e-19 69.7 0.0 2.9e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain Methyltransf_16 PF10294.9 ORX63004.1 - 1e-35 123.1 0.0 1.3e-35 122.6 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_25 PF13649.6 ORX63004.1 - 2.7e-05 24.8 0.0 4.8e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX63004.1 - 6e-05 22.9 0.0 8.2e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX63004.1 - 0.00088 19.1 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX63004.1 - 0.0023 18.6 0.0 0.004 17.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX63004.1 - 0.008 16.9 0.0 0.015 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 ORX63004.1 - 0.0097 16.9 0.0 0.017 16.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain SH3_9 PF14604.6 ORX63006.1 - 8.3e-28 96.0 2.5 4.6e-14 52.0 0.2 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 ORX63006.1 - 1.9e-25 88.2 2.1 2.3e-12 46.3 0.2 2.5 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 ORX63006.1 - 1.2e-23 83.2 0.0 2.7e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 ORX63006.1 - 9.8e-17 60.4 0.1 4.2e-07 29.5 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain TFIIA PF03153.13 ORX63006.1 - 0.0015 18.6 43.8 0.002 18.2 43.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit LAP1C PF05609.12 ORX63006.1 - 0.41 9.7 33.3 0.65 9.0 33.3 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF936 PF06075.12 ORX63006.1 - 3.5 6.4 33.9 4.4 6.1 33.9 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) CRT10 PF08728.10 ORX63006.1 - 8.2 4.5 18.5 12 4.0 18.5 1.2 1 0 0 1 1 1 0 CRT10 Ribosomal_S26e PF01283.19 ORX63007.1 - 1.5e-53 179.8 9.9 1.8e-53 179.6 9.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e LRV PF01816.17 ORX63007.1 - 1.6 9.3 6.3 3.3 8.3 6.3 1.5 1 0 0 1 1 1 0 Leucine rich repeat variant SAC3_GANP PF03399.16 ORX63008.1 - 2.4e-23 83.0 2.1 1.3e-21 77.3 2.1 2.0 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ORX63008.1 - 0.00017 21.6 0.0 0.00029 20.9 0.0 1.4 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family PSS PF03034.15 ORX63009.1 - 2.5e-105 352.2 11.3 2.5e-105 352.2 11.3 2.8 3 0 0 3 3 2 1 Phosphatidyl serine synthase ABC_membrane PF00664.23 ORX63009.1 - 2.8e-53 181.3 41.3 5.9e-33 114.7 16.2 3.1 3 0 0 3 3 3 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX63009.1 - 8e-53 178.6 0.1 1.8e-27 96.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 ORX63009.1 - 1.7e-09 37.5 1.6 0.00062 19.3 0.0 4.1 2 2 1 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ORX63009.1 - 2.5e-07 31.4 1.4 0.00077 20.0 0.1 2.3 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 ORX63009.1 - 3e-06 26.9 0.4 0.072 12.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 ORX63009.1 - 0.00013 22.3 1.9 0.33 11.2 0.1 3.0 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 ORX63009.1 - 0.00019 20.6 1.1 0.13 11.3 0.2 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_25 PF13481.6 ORX63009.1 - 0.0002 21.0 0.4 0.044 13.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ORX63009.1 - 0.00023 21.2 0.3 0.73 9.9 0.1 3.3 3 0 0 3 3 3 1 50S ribosome-binding GTPase DUF87 PF01935.17 ORX63009.1 - 0.00039 20.6 0.7 0.12 12.4 0.1 2.4 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_16 PF13191.6 ORX63009.1 - 0.00094 19.6 0.1 2.6 8.4 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 ORX63009.1 - 0.0014 18.8 0.7 0.082 13.1 0.1 2.8 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ORX63009.1 - 0.0015 18.5 0.2 0.07 13.0 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 ORX63009.1 - 0.0021 17.4 0.1 0.96 8.7 0.0 2.3 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_15 PF13175.6 ORX63009.1 - 0.0024 17.7 0.3 1.9 8.1 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 ORX63009.1 - 0.0027 17.6 0.6 2.6 7.8 0.2 3.0 2 1 1 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_18 PF13238.6 ORX63009.1 - 0.0055 17.3 0.2 7.1 7.2 0.0 3.0 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 ORX63009.1 - 0.0064 16.2 6.3 2.9 7.6 0.0 4.4 5 0 0 5 5 4 1 IstB-like ATP binding protein CbiA PF01656.23 ORX63009.1 - 0.018 15.1 0.1 0.73 9.9 0.0 2.8 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA PF00004.29 ORX63009.1 - 0.03 14.8 0.0 8.6 6.8 0.1 2.9 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX63009.1 - 0.046 13.4 0.7 6.8 6.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ORX63009.1 - 0.049 13.1 0.2 5.3 6.5 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX63009.1 - 0.066 12.5 0.0 10 5.3 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin cobW PF02492.19 ORX63009.1 - 0.096 12.3 2.9 0.14 11.7 0.2 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 ORX63009.1 - 0.11 12.8 0.3 28 5.0 0.1 2.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 ORX63009.1 - 0.11 12.5 0.4 17 5.3 0.1 2.6 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_24 PF13479.6 ORX63009.1 - 0.13 11.9 1.2 13 5.4 0.2 2.5 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 ORX63009.1 - 0.15 10.9 1.0 6.9 5.5 0.1 2.2 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Pox_A32 PF04665.12 ORX63009.1 - 0.22 10.9 0.8 8.8 5.7 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_5 PF07728.14 ORX63009.1 - 0.28 11.2 1.0 20 5.2 0.1 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) MobB PF03205.14 ORX63009.1 - 0.35 10.8 1.0 7 6.6 0.0 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B NB-ARC PF00931.22 ORX63009.1 - 0.39 9.9 2.2 6.2 5.9 0.1 3.0 3 0 0 3 3 3 0 NB-ARC domain ATP_bind_1 PF03029.17 ORX63009.1 - 0.48 10.2 1.8 33 4.1 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 ORX63009.1 - 2 8.3 3.5 45 3.9 0.1 3.1 4 0 0 4 4 3 0 NTPase Complex1_LYR PF05347.15 ORX63010.1 - 2.2e-18 66.0 1.2 3.1e-18 65.5 1.2 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ORX63010.1 - 3.6e-06 27.6 0.9 4e-06 27.5 0.9 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 ORX63010.1 - 0.00036 21.1 0.6 0.00044 20.8 0.6 1.2 1 1 0 1 1 1 1 Complex1_LYR-like PAP1 PF08601.10 ORX63011.1 - 9.5 5.8 17.5 11 5.6 17.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Methyltransf_25 PF13649.6 ORX63012.1 - 9.5e-12 45.5 0.0 3.5e-11 43.7 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ORX63012.1 - 1.7e-11 44.6 0.0 4.8e-11 43.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ORX63012.1 - 9.1e-08 32.1 0.0 1.3e-07 31.6 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX63012.1 - 1.2e-06 28.4 0.0 6.1e-06 26.1 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_2 PF00891.18 ORX63012.1 - 0.00019 20.8 0.0 0.00031 20.1 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 ORX63012.1 - 0.00029 21.5 0.0 0.0012 19.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ORX63012.1 - 0.00061 19.3 0.0 0.0026 17.2 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_8 PF05148.15 ORX63012.1 - 0.0095 15.8 0.0 0.017 15.0 0.0 1.4 1 1 0 1 1 1 1 Hypothetical methyltransferase Ubie_methyltran PF01209.18 ORX63012.1 - 0.011 15.1 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family CheR PF01739.18 ORX63012.1 - 0.018 14.5 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain ArfGap PF01412.18 ORX63013.1 - 1.9e-34 118.2 0.5 5.9e-34 116.6 0.5 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 ORX63013.1 - 2.6e-14 53.5 1.6 2.6e-14 53.5 1.6 2.5 2 1 0 2 2 2 1 BAR domain of APPL family PH PF00169.29 ORX63013.1 - 2.9e-14 53.4 0.2 6.5e-14 52.3 0.2 1.6 1 0 0 1 1 1 1 PH domain Sterile PF03015.19 ORX63013.1 - 0.28 11.4 1.0 0.91 9.8 0.1 2.3 2 0 0 2 2 2 0 Male sterility protein BAR PF03114.18 ORX63013.1 - 0.45 10.1 5.8 0.33 10.6 1.9 2.6 2 1 0 2 2 2 0 BAR domain Cellulase PF00150.18 ORX63014.1 - 1.9e-10 40.7 0.0 4.5e-10 39.4 0.0 1.6 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) OrfB_Zn_ribbon PF07282.11 ORX63019.1 - 0.028 14.3 0.4 0.084 12.8 0.4 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain E1-E2_ATPase PF00122.20 ORX63022.1 - 6.4e-46 156.2 4.7 6.4e-46 156.2 4.7 3.6 4 0 0 4 4 4 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ORX63022.1 - 5.7e-34 117.4 1.4 5.7e-34 117.4 1.4 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ORX63022.1 - 1.1e-19 70.3 0.0 2.2e-19 69.3 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 ORX63022.1 - 5.6e-18 64.4 0.8 1.3e-17 63.2 0.0 2.0 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase PF00702.26 ORX63022.1 - 1.5e-15 58.1 1.1 8.6e-14 52.3 0.3 3.6 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ORX63022.1 - 0.0012 18.6 1.6 0.0027 17.5 0.5 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase TMEM52 PF14979.6 ORX63022.1 - 0.13 12.1 0.2 0.31 10.9 0.2 1.6 1 0 0 1 1 1 0 Transmembrane 52 SOR_SNZ PF01680.17 ORX63023.1 - 2.4e-113 377.0 4.8 2.4e-113 377.0 4.8 1.9 2 0 0 2 2 2 1 SOR/SNZ family ThiG PF05690.14 ORX63023.1 - 1.8e-10 40.5 6.8 6.2e-08 32.2 0.3 2.5 2 1 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 ORX63023.1 - 6.5e-05 22.2 0.6 0.16 11.1 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.14 ORX63023.1 - 0.012 14.8 0.2 0.3 10.3 0.0 2.5 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase OMPdecase PF00215.24 ORX63023.1 - 0.013 15.1 0.0 0.57 9.7 0.0 2.3 1 1 1 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family His_biosynth PF00977.21 ORX63023.1 - 0.015 14.7 0.7 0.69 9.3 0.0 2.8 2 1 1 3 3 3 0 Histidine biosynthesis protein IGPS PF00218.21 ORX63023.1 - 0.027 13.6 0.0 0.86 8.7 0.0 2.5 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase TetR_C_27 PF17935.1 ORX63023.1 - 0.031 14.3 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain NMO PF03060.15 ORX63023.1 - 0.077 12.4 4.3 0.71 9.2 0.1 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase zf-C3HC4_4 PF15227.6 ORX63024.1 - 6.3e-06 26.2 6.5 4.4e-05 23.5 6.7 2.4 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ORX63024.1 - 5.7e-05 22.9 2.3 0.00012 21.9 2.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 ORX63024.1 - 7.4e-05 22.5 10.2 0.00022 21.0 10.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ORX63024.1 - 0.0005 20.0 6.9 0.0028 17.6 6.9 2.4 1 1 0 1 1 1 1 RING-type zinc-finger Sina PF03145.16 ORX63024.1 - 0.0011 19.0 5.2 0.0011 19.0 5.2 3.2 1 1 3 4 4 4 2 Seven in absentia protein family zf-C3HC4 PF00097.25 ORX63024.1 - 0.0031 17.4 10.5 0.012 15.5 10.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 ORX63024.1 - 0.0062 17.2 24.6 0.041 14.6 4.1 3.5 1 1 2 3 3 3 2 TRAF-type zinc finger Prok-RING_4 PF14447.6 ORX63024.1 - 0.071 13.0 6.6 0.21 11.4 6.6 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_14 PF17978.1 ORX63024.1 - 0.12 12.8 4.3 0.31 11.5 4.3 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-TRAF_2 PF15965.5 ORX63024.1 - 5.8 7.5 20.5 0.053 14.0 10.4 2.6 1 1 2 3 3 3 0 TRAF-like zinc-finger Sulfate_transp PF00916.20 ORX63025.1 - 1.1e-97 327.3 22.4 1.3e-97 326.9 22.4 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ORX63025.1 - 9.7e-09 34.9 0.0 2e-08 33.9 0.0 1.5 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 ORX63025.1 - 5.1e-05 23.6 3.9 5.1e-05 23.6 3.9 2.8 2 0 0 2 2 2 1 Molybdate transporter of MFS superfamily CENP-B_dimeris PF09026.10 ORX63025.1 - 0.42 11.0 5.2 1.1 9.7 5.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ORX63025.1 - 0.83 9.3 3.6 1.2 8.8 3.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pkinase PF00069.25 ORX63026.1 - 1.4e-71 241.0 0.0 2.1e-71 240.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63026.1 - 2.6e-53 180.9 0.0 4.5e-53 180.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 ORX63026.1 - 1.4e-20 73.4 0.1 6.5e-20 71.2 0.0 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain Pkinase_fungal PF17667.1 ORX63026.1 - 2.7e-08 33.0 0.4 6.1e-08 31.8 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ORX63026.1 - 5.3e-06 25.9 0.0 8.9e-06 25.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ORX63026.1 - 0.005 15.8 0.1 0.021 13.8 0.1 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ORX63026.1 - 0.013 14.8 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ORX63026.1 - 0.05 13.5 0.6 1 9.2 0.2 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family FTA2 PF13095.6 ORX63026.1 - 0.098 12.3 0.1 0.17 11.5 0.1 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 PepSY_TM PF03929.16 ORX63026.1 - 0.15 11.7 0.0 0.15 11.7 0.0 2.0 2 1 0 2 2 2 0 PepSY-associated TM region DUF3340 PF11818.8 ORX63028.1 - 0.058 13.6 4.4 0.076 13.2 4.4 1.1 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) ATP-synt_DE PF00401.20 ORX63028.1 - 0.14 12.4 0.6 0.14 12.4 0.6 1.8 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain DUF4407 PF14362.6 ORX63028.1 - 0.46 9.8 4.5 0.51 9.6 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CAP_GLY PF01302.25 ORX63029.1 - 2.3e-20 72.3 0.0 3.8e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain OmpH PF03938.14 ORX63029.1 - 0.018 15.4 5.5 0.018 15.4 5.5 6.2 3 2 3 6 6 6 0 Outer membrane protein (OmpH-like) CLIP1_ZNF PF16641.5 ORX63029.1 - 0.45 10.4 9.6 3.5 7.6 2.2 2.5 2 0 0 2 2 2 0 CLIP1 zinc knuckle DUF4407 PF14362.6 ORX63029.1 - 5.9 6.1 61.9 7.4 5.8 23.9 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) WD40 PF00400.32 ORX63030.1 - 4.6e-08 33.6 0.6 0.055 14.4 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63030.1 - 0.00042 20.6 0.0 0.46 10.8 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 ORX63030.1 - 0.024 14.4 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 TUP1-like enhancer of split 5_nucleotid PF05761.14 ORX63032.1 - 1e-108 364.2 0.0 1.2e-108 363.9 0.0 1.1 1 0 0 1 1 1 1 5' nucleotidase family ubiquitin PF00240.23 ORX63033.1 - 4.2e-17 61.6 0.4 7.5e-17 60.9 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ORX63033.1 - 0.00041 20.1 0.3 0.00069 19.4 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ORX63033.1 - 0.00056 20.4 1.2 0.0015 19.1 0.0 2.3 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ORX63033.1 - 0.11 12.5 0.0 0.38 10.9 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ORX63033.1 - 0.22 11.6 0.4 3.2 7.9 0.4 2.3 1 1 0 1 1 1 0 Ubiquitin-like domain ubiquitin PF00240.23 ORX63034.1 - 0.00056 19.6 0.1 0.0011 18.6 0.1 1.5 1 1 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ORX63034.1 - 0.036 14.5 0.1 0.2 12.2 0.1 2.0 1 1 0 1 1 1 0 Ubiquitin-like domain Presenilin PF01080.17 ORX63034.1 - 2.8 6.6 5.5 3 6.5 5.5 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ORX63034.1 - 4.3 6.0 9.2 4.8 5.9 9.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AC_N PF16214.5 ORX63034.1 - 6.8 5.7 12.6 8 5.5 12.6 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region ORC6 PF05460.13 ORX63034.1 - 8.9 5.5 13.8 10 5.3 13.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) NBP1 PF08537.10 ORX63035.1 - 0.017 14.6 0.1 0.02 14.3 0.1 1.1 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 DAHP_synth_2 PF01474.16 ORX63036.1 - 2.7e-188 625.9 0.0 1.1e-186 620.7 0.0 2.0 1 1 0 1 1 1 1 Class-II DAHP synthetase family NUDIX PF00293.28 ORX63037.1 - 3.2e-11 43.4 0.1 4.2e-11 43.0 0.1 1.2 1 0 0 1 1 1 1 NUDIX domain RXLR PF16810.5 ORX63038.1 - 0.057 13.9 0.8 10 6.6 0.4 3.0 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Response_reg PF00072.24 ORX63039.1 - 1.2e-22 80.2 0.5 8e-21 74.3 0.5 2.5 1 1 0 1 1 1 1 Response regulator receiver domain Metallophos PF00149.28 ORX63040.1 - 3.6e-36 125.6 0.3 5.4e-36 125.0 0.3 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ORX63040.1 - 4.4e-14 52.7 0.3 9e-14 51.6 0.3 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Pkinase PF00069.25 ORX63041.1 - 2e-55 188.0 0.0 2.5e-55 187.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63041.1 - 9.7e-41 139.8 0.0 1.4e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ORX63041.1 - 1.7e-07 30.4 0.0 2.5e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ORX63041.1 - 2e-06 27.3 0.0 2.4e-05 23.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ORX63041.1 - 0.041 13.8 0.0 0.089 12.7 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family PP2C PF00481.21 ORX63042.1 - 3.4e-42 144.9 0.0 5.6e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 ORX63042.1 - 3.5e-35 119.6 68.9 9e-07 28.6 3.3 10.5 8 1 6 14 14 14 12 Leucine rich repeat LRR_4 PF12799.7 ORX63042.1 - 7.6e-28 96.1 80.2 0.00093 19.5 0.3 12.9 10 2 2 12 12 12 10 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 ORX63042.1 - 4.1e-27 95.0 0.0 9.4e-27 93.8 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RA PF00788.23 ORX63042.1 - 3.5e-06 27.5 0.1 1.2e-05 25.9 0.0 1.9 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain LRR_9 PF14580.6 ORX63042.1 - 0.04 13.4 20.8 0.42 10.1 0.6 5.0 3 2 1 5 5 5 0 Leucine-rich repeat LRR_1 PF00560.33 ORX63042.1 - 0.091 13.4 51.6 13 6.8 0.0 13.6 13 0 0 13 13 13 0 Leucine Rich Repeat PP2C_2 PF13672.6 ORX63042.1 - 0.15 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Protein phosphatase 2C OrfB_Zn_ribbon PF07282.11 ORX63043.1 - 8.2e-10 38.5 1.3 8.2e-10 38.5 1.3 2.6 2 0 0 2 2 2 1 Putative transposase DNA-binding domain XRCC4 PF06632.12 ORX63043.1 - 0.46 9.3 8.6 5.9 5.6 0.0 2.3 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DZR PF12773.7 ORX63043.1 - 1.1 9.4 7.9 1.4 9.0 4.4 2.3 2 0 0 2 2 2 0 Double zinc ribbon Pga1 PF10333.9 ORX63044.1 - 0.043 13.7 0.0 0.05 13.5 0.0 1.1 1 0 0 1 1 1 0 GPI-Mannosyltransferase II co-activator Usp PF00582.26 ORX63047.1 - 9.1e-22 78.1 1.6 5.1e-21 75.7 1.6 1.8 1 1 0 1 1 1 1 Universal stress protein family NUDIX PF00293.28 ORX63048.1 - 1.3e-10 41.5 0.0 3e-10 40.3 0.0 1.6 2 0 0 2 2 2 1 NUDIX domain DUF1126 PF06565.12 ORX63049.1 - 0.084 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 DUF1126 PH-like domain CAP_GLY PF01302.25 ORX63050.1 - 5.5e-13 48.7 0.0 8.5e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 ORX63050.1 - 2.6e-08 33.5 13.6 3.4e-06 26.8 1.7 2.3 2 0 0 2 2 2 2 CLIP1 zinc knuckle Filament PF00038.21 ORX63050.1 - 0.0002 21.1 58.9 0.00024 20.8 33.9 2.2 2 0 0 2 2 2 2 Intermediate filament protein UPF0242 PF06785.11 ORX63050.1 - 0.25 11.4 61.6 0.033 14.3 15.1 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 ORX63050.1 - 0.84 9.0 63.2 0.084 12.3 17.7 3.4 3 0 0 3 3 3 0 Golgin subfamily A member 5 LRR_8 PF13855.6 ORX63051.1 - 3.2e-14 52.4 18.9 2.6e-07 30.3 0.2 4.6 2 2 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ORX63051.1 - 4.3e-08 33.3 17.7 0.0036 17.7 0.1 5.1 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ORX63051.1 - 0.0013 18.6 0.5 5.7 7.3 0.0 4.2 3 0 0 3 3 3 2 Leucine Rich repeat LRR_1 PF00560.33 ORX63051.1 - 0.076 13.6 21.5 0.81 10.5 0.0 7.4 8 0 0 8 8 8 0 Leucine Rich Repeat Glyco_transf_15 PF01793.16 ORX63052.1 - 5.4e-87 292.1 11.0 6.2e-87 291.9 11.0 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase WD40 PF00400.32 ORX63054.1 - 8.4e-40 134.0 23.9 5.2e-07 30.3 0.5 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63054.1 - 6.2e-16 58.5 1.7 0.029 14.7 0.0 7.0 3 2 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain F-box-like PF12937.7 ORX63054.1 - 1.5e-10 40.8 0.3 3e-10 39.8 0.3 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ORX63054.1 - 5.5e-06 26.1 0.4 1.5e-05 24.7 0.4 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 ORX63054.1 - 2.8e-05 23.0 10.0 0.12 11.0 0.0 5.8 3 2 4 7 7 7 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ORX63054.1 - 0.00067 19.1 0.0 0.11 11.8 0.0 2.9 3 0 0 3 3 3 1 WD40-like domain Elongin_A PF06881.11 ORX63054.1 - 0.0026 18.2 0.9 0.0067 16.9 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A PQQ_2 PF13360.6 ORX63054.1 - 0.0081 15.8 1.9 0.12 11.9 1.6 2.7 1 1 1 2 2 2 1 PQQ-like domain MgtE_N PF03448.17 ORX63054.1 - 0.03 14.9 0.0 0.056 14.0 0.0 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain Ge1_WD40 PF16529.5 ORX63054.1 - 0.093 11.7 2.2 0.33 9.9 1.2 2.5 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ORX63054.1 - 0.11 13.0 0.3 22 5.7 0.0 4.0 3 1 0 3 3 3 0 PQQ-like domain PALB2_WD40 PF16756.5 ORX63054.1 - 0.12 11.3 3.4 3.7 6.4 0.0 3.9 2 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain COX7a PF02238.15 ORX63055.1 - 1.7e-16 60.4 0.1 1.9e-16 60.2 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII DEAD PF00270.29 ORX63056.1 - 9.6e-47 159.0 0.0 3e-46 157.4 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ORX63056.1 - 1.3e-30 106.0 2.6 3.2e-29 101.5 0.1 3.1 3 1 0 3 3 3 1 Helicase conserved C-terminal domain SIT PF15330.6 ORX63063.1 - 0.051 14.0 0.3 0.13 12.7 0.0 1.8 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT Complex1_LYR PF05347.15 ORX63064.1 - 0.0003 20.8 0.1 0.00056 19.9 0.1 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) ING PF12998.7 ORX63064.1 - 0.014 15.9 0.5 0.014 15.9 0.5 1.6 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Mg_chelatase_C PF13335.6 ORX63064.1 - 0.14 12.8 1.6 0.24 12.1 1.6 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI C-terminal PLDc PF00614.22 ORX63065.1 - 5.4e-16 58.0 2.2 1.4e-08 34.6 0.4 2.7 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ORX63065.1 - 1.5e-15 57.2 0.7 3e-07 30.4 0.5 3.2 2 1 0 2 2 2 2 PLD-like domain Hydrolase_6 PF13344.6 ORX63066.1 - 1.4e-24 86.1 0.0 3.4e-24 84.9 0.0 1.7 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ORX63066.1 - 5.9e-21 74.3 0.0 9.5e-20 70.4 0.0 2.3 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 ORX63066.1 - 0.0047 17.2 0.0 0.75 10.0 0.0 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ORX63066.1 - 0.19 11.8 0.0 3 7.9 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase WD40 PF00400.32 ORX63067.1 - 1.4e-28 98.5 18.2 2e-07 31.5 0.0 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63067.1 - 5.5e-07 29.8 0.3 0.084 13.2 0.0 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX63067.1 - 0.0048 16.3 0.0 0.1 11.9 0.0 2.5 2 1 1 3 3 3 1 WD40-like domain DUF627 PF04781.12 ORX63067.1 - 0.013 15.5 0.0 0.064 13.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF627) WD40 PF00400.32 ORX63068.1 - 5.7e-14 52.3 15.9 0.00079 20.2 0.3 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63068.1 - 3.4e-07 30.5 0.2 0.17 12.2 0.0 3.9 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ORX63068.1 - 5.1e-07 29.3 0.0 0.00047 19.6 0.0 2.5 2 1 1 3 3 3 2 WD40-like domain Kelch_6 PF13964.6 ORX63068.1 - 8e-06 26.0 0.2 2.7 8.4 0.0 4.2 4 0 0 4 4 4 2 Kelch motif PQQ_3 PF13570.6 ORX63068.1 - 0.0031 18.0 0.1 7.7 7.1 0.0 3.8 3 0 0 3 3 3 1 PQQ-like domain BBS2_Mid PF14783.6 ORX63068.1 - 0.0059 16.6 0.1 3.1 7.9 0.0 4.1 2 1 4 6 6 6 2 Ciliary BBSome complex subunit 2, middle region Kelch_1 PF01344.25 ORX63068.1 - 0.018 14.6 0.1 6 6.5 0.0 2.7 3 0 0 3 3 3 0 Kelch motif HipA_C PF07804.12 ORX63068.1 - 0.04 13.6 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 HipA-like C-terminal domain PALB2_WD40 PF16756.5 ORX63068.1 - 0.045 12.7 1.1 0.44 9.4 0.1 2.7 2 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ORX63068.1 - 0.15 11.7 0.0 0.33 10.5 0.0 1.7 2 0 0 2 2 2 0 PQQ-like domain WRKY PF03106.15 ORX63069.1 - 9.8e-11 41.7 2.2 2.3e-10 40.5 2.2 1.7 1 0 0 1 1 1 1 WRKY DNA -binding domain FLYWCH PF04500.16 ORX63069.1 - 0.027 14.6 0.2 0.053 13.6 0.2 1.4 1 0 0 1 1 1 0 FLYWCH zinc finger domain DUF4523 PF15023.6 ORX63069.1 - 0.035 13.9 0.4 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4523) DUF4770 PF15994.5 ORX63069.1 - 0.14 12.4 3.3 2 8.6 0.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) WD40 PF00400.32 ORX63070.1 - 8.8e-05 23.2 1.6 1 10.4 0.0 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Utp12 PF04003.12 ORX63070.1 - 0.015 15.6 0.2 0.027 14.8 0.2 1.5 1 0 0 1 1 1 0 Dip2/Utp12 Family PIN_4 PF13638.6 ORX63071.1 - 1.6e-20 73.7 0.0 5.6e-20 72.0 0.0 2.0 1 0 0 1 1 1 1 PIN domain EST1_DNA_bind PF10373.9 ORX63071.1 - 7e-09 35.6 0.0 1.7e-08 34.3 0.0 1.7 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain SDH_C PF18317.1 ORX63071.1 - 0.37 10.6 2.8 0.25 11.2 0.2 2.1 2 0 0 2 2 2 0 Shikimate 5'-dehydrogenase C-terminal domain Cyclin PF08613.11 ORX63072.1 - 3e-38 131.7 0.1 6e-38 130.8 0.1 1.4 1 1 1 2 2 2 1 Cyclin Cyclin_N PF00134.23 ORX63072.1 - 0.014 15.2 0.1 0.023 14.4 0.1 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Mito_carr PF00153.27 ORX63073.1 - 1e-27 95.9 5.6 8.1e-11 41.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 ORX63073.1 - 0.0088 15.2 0.6 0.065 12.4 0.1 2.4 2 1 0 2 2 2 1 Gammaproteobacterial serine protease YqhG PF11079.8 ORX63073.1 - 0.21 10.5 0.0 0.33 9.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function G6PD_N PF00479.22 ORX63074.1 - 0.015 16.0 0.1 0.095 13.3 0.0 2.2 2 1 1 3 3 3 0 Glucose-6-phosphate dehydrogenase, NAD binding domain SPOB_ab PF14682.6 ORX63074.1 - 0.13 12.4 0.3 0.48 10.5 0.0 2.2 2 1 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal FlgN PF05130.12 ORX63074.1 - 0.15 12.5 1.1 0.22 12.0 0.1 1.7 2 0 0 2 2 2 0 FlgN protein Thioredoxin_8 PF13905.6 ORX63074.1 - 0.17 12.2 2.2 21 5.5 0.0 3.1 2 2 1 3 3 3 0 Thioredoxin-like F-box-like_2 PF13013.6 ORX63075.1 - 0.001 19.0 0.0 0.0012 18.8 0.0 1.1 1 0 0 1 1 1 1 F-box-like domain DUF3090 PF11290.8 ORX63075.1 - 0.12 12.2 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) ABC_tran_CTD PF16326.5 ORX63076.1 - 0.18 12.1 0.7 0.29 11.4 0.7 1.2 1 0 0 1 1 1 0 ABC transporter C-terminal domain 5_nucleotid_C PF02872.18 ORX63077.1 - 3.3e-35 121.6 0.0 6.2e-35 120.8 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 ORX63077.1 - 1.8e-09 38.4 1.8 1.8e-09 38.4 1.8 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase TLD PF07534.16 ORX63078.1 - 2e-37 128.5 0.1 2.3e-37 128.3 0.1 1.0 1 0 0 1 1 1 1 TLD G6PD_C PF02781.16 ORX63079.1 - 5e-114 380.4 0.0 7e-114 379.9 0.0 1.1 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ORX63079.1 - 3.4e-57 193.9 0.1 1.5e-56 191.8 0.1 2.0 2 0 0 2 2 2 1 Glucose-6-phosphate dehydrogenase, NAD binding domain SANT_DAMP1_like PF16282.5 ORX63080.1 - 7.1e-31 106.2 8.4 1.3e-30 105.4 8.4 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 ORX63080.1 - 0.00014 21.8 0.1 0.00014 21.8 0.1 1.9 2 0 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) DMAP1_like PF17024.5 ORX63080.1 - 0.017 15.2 0.0 0.052 13.7 0.0 1.8 1 0 0 1 1 1 0 Putative DMAP1-like Myb_DNA-binding PF00249.31 ORX63080.1 - 0.19 12.0 1.2 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 Myb-like DNA-binding domain OSR1_C PF12202.8 ORX63081.1 - 0.098 12.9 0.1 0.23 11.7 0.1 1.7 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain eIF3g PF12353.8 ORX63083.1 - 0.35 11.3 2.0 0.47 10.9 1.9 1.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G AMPK1_CBM PF16561.5 ORX63085.1 - 1.6e-19 69.9 0.0 2.4e-19 69.3 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase CBM53 PF16760.5 ORX63085.1 - 0.00019 21.9 0.1 0.00027 21.4 0.1 1.2 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) CBM_48 PF02922.18 ORX63085.1 - 0.00037 20.8 0.0 0.00064 20.0 0.0 1.3 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Speriolin_N PF15058.6 ORX63085.1 - 0.016 15.3 0.3 0.02 15.0 0.3 1.2 1 0 0 1 1 1 0 Speriolin N terminus Anp1 PF03452.14 ORX63086.1 - 1.2e-84 283.9 0.3 1.4e-84 283.6 0.3 1.1 1 0 0 1 1 1 1 Anp1 SWIRM PF04433.17 ORX63087.1 - 2.7e-08 34.0 0.0 4.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Pribosyl_synth PF14572.6 ORX63088.1 - 1.1e-41 142.9 1.3 5e-41 140.7 1.3 1.9 1 1 0 1 1 1 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 ORX63088.1 - 1.9e-41 140.6 0.8 5.1e-41 139.3 0.2 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 ORX63088.1 - 2.6e-09 36.8 0.8 2.2e-07 30.5 0.4 2.9 2 1 0 2 2 2 1 Phosphoribosyl transferase domain DUF4992 PF16383.5 ORX63088.1 - 0.0036 16.9 0.1 0.01 15.4 0.1 1.8 1 0 0 1 1 1 1 Domain of unknown function Kinesin PF00225.23 ORX63090.1 - 1e-110 369.8 0.0 1.7e-110 369.1 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Kinesin_assoc PF16183.5 ORX63090.1 - 5.9e-43 147.1 0.7 5.9e-43 147.1 0.7 4.2 5 1 0 5 5 5 1 Kinesin-associated Microtub_bd PF16796.5 ORX63090.1 - 4.5e-23 81.8 0.0 1.2e-22 80.5 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding DUF3694 PF12473.8 ORX63090.1 - 1.1e-17 65.2 0.2 3.5e-17 63.5 0.2 1.9 1 0 0 1 1 1 1 Kinesin protein PH PF00169.29 ORX63090.1 - 2.7e-06 27.9 0.0 9e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 PH domain FHA PF00498.26 ORX63090.1 - 0.0012 19.2 0.1 0.0089 16.4 0.0 2.5 2 0 0 2 2 2 1 FHA domain DUF89 PF01937.19 ORX63091.1 - 3e-111 371.8 1.2 3.4e-111 371.6 1.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF1843 PF08898.10 ORX63091.1 - 0.072 13.6 0.1 0.17 12.4 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) ATP-synt_G PF04718.15 ORX63092.1 - 8.4e-19 68.3 1.2 1.1e-18 67.9 1.2 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Lon_C PF05362.13 ORX63093.1 - 1.1e-66 224.3 0.0 1.9e-66 223.5 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 ORX63093.1 - 2.6e-25 89.4 0.0 8.5e-25 87.7 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 ORX63093.1 - 7.1e-11 42.4 0.0 1.8e-10 41.0 0.0 1.7 2 0 0 2 2 1 1 ATP-dependent protease La (LON) substrate-binding domain ChlI PF13541.6 ORX63093.1 - 1.8e-10 40.7 0.0 3.5e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 ORX63093.1 - 6.2e-07 29.5 0.0 1.7e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ORX63093.1 - 2.9e-06 27.6 0.5 0.00037 20.8 0.0 3.3 2 2 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ORX63093.1 - 3.3e-06 27.6 0.1 1.4e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ORX63093.1 - 5.9e-05 22.9 0.0 0.00023 21.0 0.0 1.9 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ORX63093.1 - 0.00016 21.8 0.0 0.00048 20.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 ORX63093.1 - 0.00019 21.4 0.0 0.00063 19.8 0.0 2.0 2 0 0 2 2 1 1 AAA domain NB-ARC PF00931.22 ORX63093.1 - 0.00032 19.9 0.0 0.00063 19.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 ORX63093.1 - 0.00052 20.2 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ORX63093.1 - 0.00059 19.7 0.0 0.0024 17.7 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ORX63093.1 - 0.00094 19.1 0.0 0.014 15.4 0.0 2.5 2 0 0 2 2 2 1 NACHT domain RNA_helicase PF00910.22 ORX63093.1 - 0.00094 19.5 0.0 0.0036 17.7 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_PrkA PF08298.11 ORX63093.1 - 0.0016 17.4 0.0 0.0025 16.8 0.0 1.2 1 0 0 1 1 1 1 PrkA AAA domain AAA_18 PF13238.6 ORX63093.1 - 0.0019 18.8 0.0 0.0049 17.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ORX63093.1 - 0.0022 17.8 0.1 0.013 15.2 0.0 2.0 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase IstB_IS21 PF01695.17 ORX63093.1 - 0.0031 17.3 0.0 0.0057 16.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein NTPase_1 PF03266.15 ORX63093.1 - 0.0086 16.0 0.0 0.026 14.4 0.0 1.7 1 1 1 2 2 2 1 NTPase AAA_7 PF12775.7 ORX63093.1 - 0.014 15.0 0.2 0.68 9.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region TniB PF05621.11 ORX63093.1 - 0.016 14.6 0.0 2.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_17 PF13207.6 ORX63093.1 - 0.017 15.5 0.0 0.039 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ORX63093.1 - 0.019 14.9 0.0 0.047 13.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ORX63093.1 - 0.021 15.3 0.1 0.17 12.4 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Rad17 PF03215.15 ORX63093.1 - 0.024 14.5 0.0 0.05 13.5 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 ORX63093.1 - 0.024 15.1 0.2 0.15 12.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ORX63093.1 - 0.033 14.2 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 ORX63093.1 - 0.051 13.3 0.0 0.23 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain CbiA PF01656.23 ORX63093.1 - 0.051 13.6 0.1 0.18 11.9 0.0 1.9 2 0 0 2 2 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Mg_chelatase PF01078.21 ORX63093.1 - 0.083 12.3 0.0 0.22 10.9 0.0 1.7 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 ORX63093.1 - 0.098 12.4 0.0 0.23 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ORX63093.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ORX63093.1 - 0.1 11.8 0.0 0.21 10.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 ORX63093.1 - 0.11 12.4 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 ORX63093.1 - 0.13 12.3 0.0 0.34 11.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase MutS_V PF00488.21 ORX63094.1 - 4.3e-62 209.5 1.4 1.8e-61 207.4 0.6 2.1 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ORX63094.1 - 8.7e-35 120.7 0.0 1.5e-34 119.9 0.0 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ORX63094.1 - 9e-35 119.3 0.1 1.7e-34 118.4 0.1 1.5 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ORX63094.1 - 7e-12 45.8 0.0 1.9e-11 44.4 0.0 1.8 1 0 0 1 1 1 1 MutS domain II MutS_IV PF05190.18 ORX63094.1 - 9.4e-11 41.9 0.0 2.5e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 ORX63094.1 - 0.013 15.5 0.0 0.2 11.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain LEDGF PF11467.8 ORX63094.1 - 0.079 12.6 0.1 0.19 11.3 0.1 1.6 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) CDC27 PF09507.10 ORX63095.1 - 0.002 17.6 4.8 0.0025 17.3 4.8 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 NOA36 PF06524.12 ORX63095.1 - 0.95 8.7 4.2 1.2 8.4 4.2 1.1 1 0 0 1 1 1 0 NOA36 protein DTHCT PF08070.11 ORX63095.1 - 3.4 8.5 10.5 0.37 11.6 6.1 1.7 2 0 0 2 2 2 0 DTHCT (NUC029) region DUF4407 PF14362.6 ORX63096.1 - 1.3e-05 24.8 98.4 0.14 11.5 14.1 5.4 1 1 4 5 5 5 4 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 ORX63096.1 - 0.0011 19.2 2.2 0.0011 19.2 2.2 9.6 2 1 7 10 10 10 5 TATA element modulatory factor 1 TATA binding BRE1 PF08647.11 ORX63096.1 - 0.0033 17.5 11.2 0.0033 17.5 11.2 9.8 1 1 9 10 10 10 3 BRE1 E3 ubiquitin ligase DUF4164 PF13747.6 ORX63096.1 - 0.037 14.3 123.1 0.22 11.8 9.7 10.6 1 1 9 11 11 11 0 Domain of unknown function (DUF4164) ABC_tran_CTD PF16326.5 ORX63096.1 - 0.042 14.1 110.8 0.18 12.1 5.4 11.8 3 2 7 12 12 12 0 ABC transporter C-terminal domain APG6_N PF17675.1 ORX63096.1 - 0.17 12.4 132.4 0.71 10.4 29.4 8.4 1 1 5 8 8 8 0 Apg6 coiled-coil region POTRA_3 PF17287.2 ORX63096.1 - 0.17 11.4 6.2 7.1 6.2 0.2 4.7 4 0 0 4 4 4 0 POTRA domain PKcGMP_CC PF16808.5 ORX63096.1 - 0.24 11.3 82.2 0.062 13.2 1.3 16.2 12 6 6 19 19 19 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GAS PF13851.6 ORX63096.1 - 0.84 9.0 111.4 0.036 13.4 15.8 7.7 1 1 4 6 6 6 0 Growth-arrest specific micro-tubule binding Peptidase_S10 PF00450.22 ORX63097.1 - 1.2e-110 370.9 0.5 1.3e-110 370.7 0.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase FlgM PF04316.13 ORX63098.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma-28 factor, FlgM Questin_oxidase PF14027.6 ORX63099.1 - 1.3e-66 225.5 1.3 1.5e-66 225.3 1.3 1.1 1 0 0 1 1 1 1 Questin oxidase-like DUF1910 PF08928.10 ORX63099.1 - 0.091 12.8 0.0 0.4 10.7 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1910) Noc2 PF03715.13 ORX63101.1 - 6.4e-86 288.3 1.1 6.4e-86 288.3 1.1 1.6 2 0 0 2 2 2 1 Noc2p family FRQ PF09421.10 ORX63101.1 - 0.24 9.4 4.5 0.31 9.0 4.5 1.1 1 0 0 1 1 1 0 Frequency clock protein bZIP_1 PF00170.21 ORX63101.1 - 1 9.5 8.7 0.21 11.7 3.6 2.4 2 0 0 2 2 2 0 bZIP transcription factor Kelch_4 PF13418.6 ORX63102.1 - 3.2e-07 30.3 3.5 0.0036 17.3 0.0 4.3 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ORX63102.1 - 4.2e-07 29.8 3.5 0.25 11.4 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ORX63102.1 - 4.2e-06 26.5 16.0 0.0014 18.5 0.3 5.9 6 2 0 6 6 6 3 Kelch motif Kelch_6 PF13964.6 ORX63102.1 - 4.7e-05 23.5 15.4 0.074 13.4 0.3 6.9 7 1 0 7 7 7 3 Kelch motif Kelch_1 PF01344.25 ORX63102.1 - 0.0003 20.3 9.1 0.0021 17.6 0.2 4.9 4 1 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ORX63102.1 - 0.34 11.2 12.5 0.99 9.8 0.2 4.2 5 1 0 5 5 5 0 Galactose oxidase, central domain Peptidase_S10 PF00450.22 ORX63103.1 - 8.4e-114 381.2 10.1 1.1e-113 380.9 10.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF702 PF05142.12 ORX63104.1 - 0.2 12.1 0.9 0.39 11.2 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF702) PH PF00169.29 ORX63108.1 - 1.9e-06 28.3 0.2 4.5e-06 27.1 0.2 1.7 1 0 0 1 1 1 1 PH domain WD40 PF00400.32 ORX63109.1 - 1.2e-39 133.6 13.8 1.1e-08 35.5 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63109.1 - 4.3e-05 23.7 0.9 1.5 9.2 0.2 4.4 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX63109.1 - 0.0066 15.1 0.6 1.4 7.5 0.3 3.2 1 1 2 3 3 3 1 Nucleoporin Nup120/160 AviRa PF11599.8 ORX63109.1 - 0.14 11.6 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Ras PF00071.22 ORX63110.1 - 1.2e-53 181.1 0.0 1.4e-53 180.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ORX63110.1 - 5.7e-20 71.7 0.0 9.3e-20 71.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ORX63110.1 - 9.6e-10 38.2 0.0 1.1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ORX63110.1 - 2e-06 27.8 0.0 0.011 15.7 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ORX63110.1 - 1.5e-05 24.6 0.0 3.9e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ORX63110.1 - 0.0058 16.7 0.0 0.013 15.6 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ORX63110.1 - 0.008 15.7 0.0 0.03 13.9 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B pPIWI_RE_Y PF18156.1 ORX63110.1 - 0.032 14.7 0.1 0.12 12.8 0.0 1.9 2 0 0 2 2 2 0 pPIWI_RE three-gene island domain Y ATP_bind_1 PF03029.17 ORX63110.1 - 0.13 12.1 0.8 0.18 11.6 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein CedA PF10729.9 ORX63110.1 - 0.13 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 Cell division activator CedA AAA_25 PF13481.6 ORX63110.1 - 0.2 11.2 0.1 0.67 9.5 0.1 1.7 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 ORX63111.1 - 6.7e-73 245.3 0.0 9.8e-73 244.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63111.1 - 8.6e-55 185.8 0.0 1.3e-54 185.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ORX63111.1 - 2.8e-05 23.9 11.3 2.8e-05 23.9 11.3 1.7 2 0 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Kinase-like PF14531.6 ORX63111.1 - 9e-05 21.9 0.0 0.032 13.6 0.0 2.4 1 1 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ORX63111.1 - 0.0027 17.4 0.1 0.0049 16.5 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Zn_ribbon_17 PF17120.5 ORX63111.1 - 0.28 10.8 9.5 0.56 9.9 9.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 ORX63111.1 - 0.43 10.5 9.4 1.5 8.8 9.4 2.0 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 ORX63111.1 - 0.69 10.1 6.3 2.4 8.3 6.3 1.9 1 0 0 1 1 1 0 KIAA1045 RING finger PHD_4 PF16866.5 ORX63111.1 - 1.1 9.4 9.3 4.9 7.3 0.2 2.6 1 1 1 2 2 2 0 PHD-finger Brix PF04427.18 ORX63112.1 - 5.2e-35 121.3 0.2 6.9e-35 120.9 0.2 1.2 1 0 0 1 1 1 1 Brix domain DUF4219 PF13961.6 ORX63113.1 - 0.092 12.4 0.0 0.23 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4219) Transket_pyr PF02779.24 ORX63115.1 - 4.3e-51 173.1 0.0 6.9e-51 172.4 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ORX63115.1 - 2.6e-50 171.1 0.0 5.3e-50 170.1 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component DnaJ PF00226.31 ORX63116.1 - 1.4e-24 86.0 0.3 3.8e-24 84.6 0.3 1.8 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 ORX63116.1 - 1.2e-09 38.1 1.4 2.6e-09 37.1 1.4 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ORX63116.1 - 2.5e-06 27.7 1.3 4.6e-06 26.8 1.3 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ORX63116.1 - 0.0072 16.6 1.0 0.015 15.6 1.0 1.6 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) CENP-B_dimeris PF09026.10 ORX63116.1 - 0.012 15.9 0.8 0.012 15.9 0.8 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf_C2H2_ZHX PF18387.1 ORX63116.1 - 0.016 14.9 1.1 0.04 13.5 0.2 2.0 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-CpG_bind_C PF12269.8 ORX63116.1 - 0.042 13.6 7.9 0.072 12.9 7.9 1.4 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain zf-C2H2 PF00096.26 ORX63116.1 - 0.042 14.3 0.8 0.11 13.0 0.8 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-U1 PF06220.12 ORX63116.1 - 0.11 12.3 0.1 0.11 12.3 0.1 1.8 2 0 0 2 2 2 0 U1 zinc finger NDUF_B4 PF07225.12 ORX63117.1 - 0.001 19.0 0.1 0.0011 18.8 0.1 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) FMN_red PF03358.15 ORX63118.1 - 7.1e-17 61.6 0.0 1e-16 61.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX63118.1 - 8.4e-09 35.4 0.0 1.1e-08 35.1 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_1 PF00258.25 ORX63118.1 - 0.007 16.6 0.0 0.44 10.8 0.0 2.7 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ORX63118.1 - 0.16 12.2 0.0 0.33 11.2 0.0 1.6 1 1 1 2 2 2 0 Flavodoxin domain FMN_red PF03358.15 ORX63119.1 - 3e-14 53.0 0.0 5.9e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX63119.1 - 1.4e-07 31.4 0.0 2.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 ORX63119.1 - 0.011 16.0 0.0 0.17 12.1 0.0 2.4 2 1 1 3 3 3 0 Flavodoxin domain ABC_membrane PF00664.23 ORX63120.1 - 2e-117 391.7 24.5 3.2e-66 223.8 13.2 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX63120.1 - 3.5e-67 225.1 0.1 1.7e-32 112.8 0.0 2.9 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 ORX63120.1 - 5.5e-17 62.0 2.2 7.7e-07 28.8 0.1 4.3 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ORX63120.1 - 9.1e-10 39.2 2.4 0.0011 19.4 0.0 3.9 3 2 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 ORX63120.1 - 2.6e-09 37.3 0.2 0.0021 17.9 0.0 4.1 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX63120.1 - 1.9e-08 34.6 2.3 0.045 14.0 0.0 4.7 4 1 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 ORX63120.1 - 5.5e-08 33.2 0.1 0.35 11.3 0.0 4.2 4 0 0 4 4 3 3 RNA helicase AAA_29 PF13555.6 ORX63120.1 - 9e-08 31.7 1.2 0.0057 16.4 0.2 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ORX63120.1 - 7.3e-07 29.2 0.3 0.08 12.8 0.0 3.4 3 0 0 3 3 3 2 RsgA GTPase AAA PF00004.29 ORX63120.1 - 7.6e-07 29.6 1.4 1.7 9.1 0.1 4.7 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ORX63120.1 - 1.1e-06 28.7 0.0 0.012 15.4 0.0 2.5 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.9 ORX63120.1 - 3.6e-06 26.1 0.5 0.02 13.7 0.0 3.0 3 1 0 3 3 3 2 Predicted ATPase of the ABC class AAA_30 PF13604.6 ORX63120.1 - 7.5e-06 25.8 0.8 0.62 9.7 0.1 4.2 4 0 0 4 4 4 2 AAA domain AAA_7 PF12775.7 ORX63120.1 - 7.9e-06 25.5 0.3 0.31 10.5 0.0 3.3 3 0 0 3 3 3 2 P-loop containing dynein motor region Zeta_toxin PF06414.12 ORX63120.1 - 1.1e-05 24.8 6.3 0.018 14.3 0.0 3.8 4 0 0 4 4 3 2 Zeta toxin G-alpha PF00503.20 ORX63120.1 - 3.3e-05 23.2 0.1 0.027 13.6 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit AAA_24 PF13479.6 ORX63120.1 - 3.8e-05 23.5 0.1 0.0094 15.7 0.0 3.0 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ORX63120.1 - 3.8e-05 23.0 0.0 0.046 12.9 0.0 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 ORX63120.1 - 4.4e-05 23.5 1.6 1 9.4 0.0 4.3 5 0 0 5 5 5 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ORX63120.1 - 6e-05 23.2 0.0 1.2 9.3 0.0 3.7 4 0 0 4 4 3 2 AAA domain AAA_18 PF13238.6 ORX63120.1 - 0.00035 21.1 0.0 1.6 9.3 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 ORX63120.1 - 0.00049 20.4 0.1 0.62 10.3 0.0 3.3 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 ORX63120.1 - 0.00066 19.7 0.1 0.093 12.6 0.0 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_14 PF13173.6 ORX63120.1 - 0.00068 19.7 0.6 2.4 8.2 0.0 4.5 5 1 0 5 5 4 1 AAA domain SbcCD_C PF13558.6 ORX63120.1 - 0.00076 19.7 4.9 0.69 10.2 0.3 4.5 3 2 0 3 3 2 1 Putative exonuclease SbcCD, C subunit NB-ARC PF00931.22 ORX63120.1 - 0.00096 18.4 1.2 5.4 6.1 0.0 3.4 3 0 0 3 3 3 0 NB-ARC domain AAA_23 PF13476.6 ORX63120.1 - 0.0013 19.3 9.1 1.2 9.7 0.0 3.4 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 ORX63120.1 - 0.0026 17.8 0.0 3.4 7.8 0.0 3.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_25 PF13481.6 ORX63120.1 - 0.0033 17.0 2.1 0.74 9.3 0.0 3.6 5 0 0 5 5 3 1 AAA domain Ploopntkinase3 PF18751.1 ORX63120.1 - 0.0035 17.3 0.1 3.7 7.4 0.0 2.5 2 0 0 2 2 2 1 P-loop Nucleotide Kinase3 PRK PF00485.18 ORX63120.1 - 0.0048 16.7 0.1 2.1 8.0 0.0 2.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family ATP-synt_ab PF00006.25 ORX63120.1 - 0.0064 16.2 0.4 0.32 10.6 0.0 2.8 3 0 0 3 3 2 1 ATP synthase alpha/beta family, nucleotide-binding domain DUF2207 PF09972.9 ORX63120.1 - 0.011 14.6 0.0 0.011 14.6 0.0 4.0 2 2 2 4 4 4 0 Predicted membrane protein (DUF2207) SRP54 PF00448.22 ORX63120.1 - 0.017 14.7 2.4 2.3 7.8 0.0 3.1 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 ORX63120.1 - 0.019 14.8 0.5 8.7 6.2 0.0 3.3 3 1 1 4 4 3 0 Adenylylsulphate kinase GMC_oxred_N PF00732.19 ORX63120.1 - 0.049 13.0 0.1 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 GMC oxidoreductase Mg_chelatase PF01078.21 ORX63120.1 - 0.085 12.2 0.7 14 5.0 0.0 3.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ORX63120.1 - 0.11 12.4 1.4 10 6.0 0.0 3.1 4 0 0 4 4 2 0 NACHT domain AAA_17 PF13207.6 ORX63120.1 - 0.16 12.4 4.3 11 6.4 0.1 3.7 4 0 0 4 4 2 0 AAA domain Roc PF08477.13 ORX63120.1 - 0.16 12.1 1.6 6.7 7.0 0.0 3.2 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase Guanylate_kin PF00625.21 ORX63120.1 - 0.22 11.2 2.6 19 4.9 0.0 3.6 4 0 0 4 4 3 0 Guanylate kinase NTPase_1 PF03266.15 ORX63120.1 - 1.5 8.7 3.7 44 3.9 0.0 4.1 5 0 0 5 5 4 0 NTPase DUF87 PF01935.17 ORX63120.1 - 2.8 8.0 8.3 1.3 9.1 0.2 3.5 4 1 0 4 4 3 0 Helicase HerA, central domain ABC_membrane PF00664.23 ORX63121.1 - 2.4e-118 394.8 38.0 6.4e-65 219.5 16.5 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ORX63121.1 - 9e-69 230.3 1.9 3.6e-35 121.5 0.0 3.0 3 0 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ORX63121.1 - 5.4e-17 62.0 0.0 3.6e-07 29.9 1.0 3.8 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ORX63121.1 - 1.8e-07 30.4 1.0 0.0015 17.4 0.1 3.2 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 ORX63121.1 - 6.8e-07 28.9 1.0 0.002 17.8 0.1 2.8 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 ORX63121.1 - 1e-06 28.8 0.1 0.039 13.8 0.0 4.0 3 1 1 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ORX63121.1 - 1.4e-06 28.7 4.3 0.18 12.1 0.2 4.7 4 1 0 4 4 4 2 AAA domain AAA_15 PF13175.6 ORX63121.1 - 1.4e-06 28.3 0.9 0.0032 17.2 0.0 2.6 3 0 0 3 3 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 ORX63121.1 - 9.2e-06 25.7 0.1 0.03 14.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA PF00004.29 ORX63121.1 - 9.7e-06 26.0 5.3 0.28 11.6 0.2 4.3 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ORX63121.1 - 1.8e-05 24.5 0.1 0.11 12.1 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ORX63121.1 - 8.8e-05 22.9 5.7 0.13 12.7 0.8 3.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_7 PF12775.7 ORX63121.1 - 0.0001 21.9 0.1 0.08 12.5 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_33 PF13671.6 ORX63121.1 - 0.00014 22.0 0.0 0.55 10.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain RNA_helicase PF00910.22 ORX63121.1 - 0.00021 21.6 0.0 4 7.9 0.0 3.6 3 0 0 3 3 3 1 RNA helicase AAA_23 PF13476.6 ORX63121.1 - 0.00024 21.7 4.1 0.027 15.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain Zeta_toxin PF06414.12 ORX63121.1 - 0.00028 20.2 0.5 0.21 10.8 0.0 3.0 3 0 0 3 3 3 1 Zeta toxin Rad17 PF03215.15 ORX63121.1 - 0.00036 20.5 0.2 0.095 12.6 0.1 2.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_5 PF07728.14 ORX63121.1 - 0.0004 20.4 0.2 3.2 7.7 0.0 3.8 4 0 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ORX63121.1 - 0.00045 20.0 0.2 0.069 12.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 ORX63121.1 - 0.00073 19.7 2.3 1.1 9.6 0.4 3.7 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit G-alpha PF00503.20 ORX63121.1 - 0.00085 18.6 0.2 0.13 11.4 0.0 2.3 2 0 0 2 2 2 1 G-protein alpha subunit AAA_18 PF13238.6 ORX63121.1 - 0.0011 19.5 0.2 2.9 8.4 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 ORX63121.1 - 0.0024 17.5 0.1 0.52 9.9 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_28 PF13521.6 ORX63121.1 - 0.022 15.0 2.8 1.1 9.5 0.0 3.3 4 0 0 4 4 2 0 AAA domain SRP54 PF00448.22 ORX63121.1 - 0.023 14.3 0.1 2.2 7.9 0.0 2.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 ORX63121.1 - 0.079 13.0 3.9 5.3 7.2 0.0 3.7 4 1 0 4 4 3 0 50S ribosome-binding GTPase GMC_oxred_N PF00732.19 ORX63121.1 - 0.094 12.1 0.1 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 GMC oxidoreductase ATP_bind_1 PF03029.17 ORX63121.1 - 0.098 12.4 1.6 2.4 7.9 0.0 2.7 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_17 PF13207.6 ORX63121.1 - 0.18 12.3 6.5 25 5.3 0.0 5.0 5 0 0 5 5 5 0 AAA domain DUF3987 PF13148.6 ORX63121.1 - 0.63 9.0 0.0 0.63 9.0 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3987) DUF87 PF01935.17 ORX63121.1 - 0.83 9.7 5.2 9.4 6.2 0.0 3.5 4 0 0 4 4 3 0 Helicase HerA, central domain ABC_tran PF00005.27 ORX63122.1 - 1.3e-13 51.6 0.1 3.3e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ORX63122.1 - 0.0011 18.5 0.1 0.0014 18.1 0.1 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ORX63122.1 - 0.0015 18.7 0.9 0.058 13.6 0.9 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit GMC_oxred_N PF00732.19 ORX63122.1 - 0.0016 17.9 0.0 0.002 17.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase ABC_ATPase PF09818.9 ORX63122.1 - 0.0051 15.7 0.1 0.0052 15.6 0.1 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class Chitin_synth_1 PF01644.17 ORX63122.1 - 0.11 12.4 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Chitin synthase APOBEC_N PF08210.11 ORX63123.1 - 0.021 14.7 0.1 0.032 14.1 0.1 1.3 1 0 0 1 1 1 0 APOBEC-like N-terminal domain APOBEC2 PF18772.1 ORX63123.1 - 0.032 14.3 0.1 0.044 13.8 0.1 1.2 1 0 0 1 1 1 0 APOBEC2 SF1-HH PF16275.5 ORX63124.1 - 4.2e-39 133.4 3.8 1.3e-38 131.8 3.8 1.9 1 0 0 1 1 1 1 Splicing factor 1 helix-hairpin domain zf-CCHC PF00098.23 ORX63124.1 - 2.1e-09 37.0 13.3 0.00012 21.9 6.1 2.4 2 0 0 2 2 2 2 Zinc knuckle KH_1 PF00013.29 ORX63124.1 - 2.8e-08 33.5 0.3 5.7e-08 32.5 0.3 1.5 1 0 0 1 1 1 1 KH domain zf-CCHC_6 PF15288.6 ORX63124.1 - 6.9e-05 22.6 5.1 0.059 13.2 0.3 2.7 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC_3 PF13917.6 ORX63124.1 - 0.0009 19.2 4.9 0.24 11.4 0.1 2.5 1 1 1 2 2 2 2 Zinc knuckle DnaJ_CXXCXGXG PF00684.19 ORX63124.1 - 0.048 14.0 2.7 0.12 12.8 2.7 1.6 1 0 0 1 1 1 0 DnaJ central domain Prim_Zn_Ribbon PF08273.12 ORX63124.1 - 0.19 12.1 2.5 0.52 10.6 2.5 1.7 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase ADK_lid PF05191.14 ORX63124.1 - 0.19 11.7 2.3 0.4 10.7 2.3 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid zf-CCHC_4 PF14392.6 ORX63124.1 - 0.41 10.4 10.4 0.79 9.5 0.6 2.4 2 0 0 2 2 2 0 Zinc knuckle CCDC-167 PF15188.6 ORX63124.1 - 0.81 10.1 4.4 1.2 9.5 0.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 zf-CCHC_2 PF13696.6 ORX63124.1 - 1.8 8.5 12.0 11 6.0 0.4 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CHY PF05495.12 ORX63125.1 - 6.8e-11 42.5 11.0 6.8e-11 42.5 11.0 3.7 2 1 1 3 3 3 1 CHY zinc finger RWD PF05773.22 ORX63125.1 - 0.00033 20.9 0.0 0.2 11.9 0.0 2.4 2 0 0 2 2 2 2 RWD domain Yippee-Mis18 PF03226.14 ORX63125.1 - 0.027 14.7 4.0 0.045 14.0 0.0 2.7 2 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly CLTH PF10607.9 ORX63126.1 - 5.9e-35 120.3 0.7 1.2e-34 119.4 0.7 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 ORX63126.1 - 0.00019 21.3 0.0 0.00043 20.1 0.0 1.6 1 0 0 1 1 1 1 LisH ACCA PF03255.14 ORX63126.1 - 0.0096 15.8 6.4 0.32 10.9 2.0 2.3 2 0 0 2 2 2 2 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Fzo_mitofusin PF04799.13 ORX63126.1 - 0.039 13.5 1.5 0.091 12.3 1.5 1.6 1 0 0 1 1 1 0 fzo-like conserved region Lipoprotein_7 PF01540.16 ORX63126.1 - 0.047 13.0 0.2 0.1 11.9 0.2 1.5 1 0 0 1 1 1 0 Adhesin lipoprotein CSN5_C PF18323.1 ORX63126.1 - 0.05 14.5 0.9 0.22 12.5 0.8 2.1 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain Pox_H7 PF04787.12 ORX63126.1 - 0.062 13.8 0.5 0.13 12.8 0.5 1.5 1 0 0 1 1 1 0 Late protein H7 DIRP PF06584.13 ORX63126.1 - 0.23 11.7 3.7 0.37 11.0 1.1 2.5 2 1 0 2 2 2 0 DIRP FlxA PF14282.6 ORX63126.1 - 0.23 11.5 2.1 0.5 10.4 2.1 1.5 1 0 0 1 1 1 0 FlxA-like protein FapA PF03961.13 ORX63126.1 - 0.56 8.8 2.0 0.88 8.1 2.0 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A CLZ PF16526.5 ORX63126.1 - 0.71 10.3 6.3 2.1 8.8 4.5 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OmpH PF03938.14 ORX63126.1 - 2.7 8.3 7.6 6.3 7.1 7.6 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Med9 PF07544.13 ORX63126.1 - 3.1 7.9 6.4 1.7 8.8 3.7 2.0 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Dcc1 PF09724.9 ORX63128.1 - 2e-71 241.0 0.0 3e-71 240.4 0.0 1.2 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 RRM_1 PF00076.22 ORX63129.1 - 9.2e-16 57.4 0.1 7.8e-12 44.9 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ORX63129.1 - 0.05 13.7 0.0 6.3 7.0 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif DUF4822 PF16103.5 ORX63129.1 - 0.092 13.0 0.2 0.2 11.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4822) Pkinase PF00069.25 ORX63131.1 - 2.7e-54 184.3 0.0 3.6e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63131.1 - 5.8e-51 173.3 0.0 7.5e-51 172.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SAP PF02037.27 ORX63131.1 - 4.7e-07 29.4 0.0 9.6e-07 28.4 0.0 1.5 1 0 0 1 1 1 1 SAP domain Haspin_kinase PF12330.8 ORX63131.1 - 0.00099 18.1 0.1 0.0014 17.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ORX63131.1 - 0.0074 16.2 0.0 0.033 14.1 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ORX63131.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LETM1 PF07766.13 ORX63131.1 - 0.086 12.2 0.6 0.15 11.4 0.1 1.6 2 0 0 2 2 2 0 LETM1-like protein DHBP_synthase PF00926.19 ORX63132.1 - 2.4e-84 281.7 0.0 2.7e-84 281.5 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase MTP18 PF10558.9 ORX63133.1 - 6.8e-63 211.7 8.1 3.4e-61 206.2 8.1 2.1 1 1 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) DUF5353 PF17304.2 ORX63133.1 - 0.05 13.4 0.6 0.094 12.5 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5353) DUF4616 PF15394.6 ORX63133.1 - 0.12 11.4 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4616) Pkinase PF00069.25 ORX63134.1 - 3.3e-69 233.2 0.0 4.3e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63134.1 - 9.2e-34 116.9 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ORX63134.1 - 0.00058 19.3 0.1 0.0012 18.3 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ORX63134.1 - 0.00078 18.5 0.1 0.0015 17.6 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain DUF2075 PF09848.9 ORX63134.1 - 0.033 13.4 0.0 0.056 12.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) APH PF01636.23 ORX63134.1 - 0.061 13.2 2.3 0.14 12.0 0.1 2.4 2 2 1 3 3 3 0 Phosphotransferase enzyme family Glyco_transf_49 PF13896.6 ORX63135.1 - 1.5e-61 208.6 1.0 1.5e-49 169.1 0.8 2.0 1 1 1 2 2 2 2 Glycosyl-transferase for dystroglycan Glyco_tranf_2_4 PF13704.6 ORX63135.1 - 0.016 15.7 1.8 0.016 15.7 0.6 1.7 2 0 0 2 2 2 0 Glycosyl transferase family 2 HLH PF00010.26 ORX63136.1 - 2.7e-13 49.7 1.6 2.8e-13 49.6 0.2 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain SOBP PF15279.6 ORX63136.1 - 0.41 11.2 27.3 0.58 10.7 27.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein zf-CHY PF05495.12 ORX63137.1 - 5.2e-14 52.5 12.6 1e-13 51.5 12.6 1.5 1 1 0 1 1 1 1 CHY zinc finger zinc_ribbon_9 PF14369.6 ORX63137.1 - 0.006 16.8 4.9 0.25 11.6 0.1 2.5 2 0 0 2 2 2 2 zinc-ribbon Zn-ribbon_8 PF09723.10 ORX63137.1 - 0.0088 16.1 4.0 0.0088 16.1 4.0 2.6 2 1 1 3 3 3 1 Zinc ribbon domain zf-UDP PF14569.6 ORX63137.1 - 0.01 15.9 3.0 0.01 15.9 3.0 1.7 1 1 1 2 2 2 0 Zinc-binding RING-finger zinc_ribbon_4 PF13717.6 ORX63137.1 - 0.063 13.2 8.3 2.2 8.3 0.6 3.3 2 1 1 3 3 2 0 zinc-ribbon domain DUF4379 PF14311.6 ORX63137.1 - 0.072 13.5 1.2 0.072 13.5 1.2 2.3 1 1 0 2 2 2 0 Probable Zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 ORX63137.1 - 0.55 10.2 12.0 12 5.9 0.1 2.9 2 1 0 2 2 2 0 Transposase zinc-ribbon domain HypA PF01155.19 ORX63137.1 - 0.83 9.7 9.0 3.3 7.8 8.9 2.0 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA LIM PF00412.22 ORX63137.1 - 1.1 9.6 11.5 10 6.5 9.7 2.4 1 1 1 2 2 2 0 LIM domain C1_4 PF07975.12 ORX63137.1 - 1.8 8.9 14.6 3.2 8.1 5.1 2.9 1 1 2 3 3 3 0 TFIIH C1-like domain Bac_surface_Ag PF01103.23 ORX63138.1 - 7.6e-46 157.1 0.5 9e-46 156.8 0.5 1.1 1 0 0 1 1 1 1 Surface antigen ShlB PF03865.13 ORX63138.1 - 0.0002 20.9 0.1 0.00032 20.3 0.1 1.4 1 0 0 1 1 1 1 Haemolysin secretion/activation protein ShlB/FhaC/HecB Hus1 PF04005.12 ORX63139.1 - 4.9e-48 163.7 0.9 5.9e-48 163.5 0.9 1.1 1 0 0 1 1 1 1 Hus1-like protein WD40 PF00400.32 ORX63140.1 - 1.8e-17 63.4 8.8 0.0013 19.5 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ORX63140.1 - 7e-06 26.3 0.1 0.02 15.2 0.0 4.4 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ORX63140.1 - 0.0011 17.7 0.1 0.65 8.6 0.0 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 MRJP PF03022.16 ORX63140.1 - 0.048 13.0 0.0 0.14 11.5 0.0 1.7 1 1 1 2 2 2 0 Major royal jelly protein Lactonase PF10282.9 ORX63140.1 - 0.074 12.3 0.1 0.9 8.7 0.1 2.0 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller DUF3246 PF11596.8 ORX63140.1 - 0.2 11.1 3.7 0.3 10.5 3.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) NOA36 PF06524.12 ORX63140.1 - 4.4 6.5 10.0 10 5.3 10.0 1.5 1 0 0 1 1 1 0 NOA36 protein CorA PF01544.18 ORX63141.1 - 2.9e-46 158.1 0.1 3.9e-46 157.7 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Baculo_PEP_C PF04513.12 ORX63141.1 - 0.057 13.5 0.5 0.12 12.4 0.5 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Allantoicase PF03561.15 ORX63142.1 - 6.3e-82 272.7 0.0 4.4e-43 146.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat LRR_RI_capping PF18779.1 ORX63142.1 - 0.0058 16.3 0.2 5.2 6.8 0.0 2.8 2 0 0 2 2 2 2 Capping Ribonuclease inhibitor Leucine Rich Repeat PDEase_I PF00233.19 ORX63143.1 - 1.2e-69 234.6 0.0 1.3e-60 205.0 0.0 2.7 3 0 0 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase Response_reg PF00072.24 ORX63143.1 - 0.0017 18.5 0.0 0.0063 16.7 0.0 2.0 1 1 0 1 1 1 1 Response regulator receiver domain Pyr_redox_2 PF07992.14 ORX63144.1 - 3.2e-41 141.5 0.1 4.1e-41 141.1 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase AIF_C PF14721.6 ORX63144.1 - 1.4e-38 132.2 0.0 3.6e-38 130.9 0.0 1.7 1 1 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term Pyr_redox PF00070.27 ORX63144.1 - 1.6e-11 44.6 0.0 2.2e-09 37.7 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ORX63144.1 - 2.7e-09 36.7 0.5 5.9e-05 22.5 0.0 2.9 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ORX63144.1 - 2.3e-07 30.7 3.6 0.0021 17.7 0.1 3.9 2 2 2 4 4 4 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ORX63144.1 - 3.1e-05 23.5 0.3 0.037 13.3 0.1 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.6 ORX63144.1 - 3.2e-05 24.0 3.7 0.53 10.3 0.3 3.7 2 2 2 4 4 4 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 ORX63144.1 - 3.8e-05 23.0 0.1 0.00058 19.1 0.0 2.2 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 ORX63144.1 - 0.0001 21.1 0.1 0.14 10.8 0.0 3.0 3 0 0 3 3 3 2 HI0933-like protein FeS_assembly_P PF01883.19 ORX63144.1 - 0.024 14.8 0.3 0.097 12.9 0.3 2.0 1 0 0 1 1 1 0 Iron-sulfur cluster assembly protein Lycopene_cycl PF05834.12 ORX63144.1 - 0.059 12.4 0.0 1.1 8.2 0.0 2.4 2 1 0 2 2 2 0 Lycopene cyclase protein DUF1357 PF07094.11 ORX63144.1 - 0.13 12.3 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1357) GIDA PF01134.22 ORX63144.1 - 1.4 7.9 3.4 20 4.1 0.3 3.1 3 0 0 3 3 3 0 Glucose inhibited division protein A Bromodomain PF00439.25 ORX63145.1 - 9.5e-24 83.3 0.0 2.2e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 ORX63145.1 - 4.3e-08 33.4 0.0 9.8e-08 32.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ORX63145.1 - 1.1e-05 25.4 0.0 2.1e-05 24.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ORX63145.1 - 0.00031 21.1 0.1 0.00063 20.1 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain malic PF00390.19 ORX63145.1 - 0.11 12.3 0.2 0.2 11.4 0.2 1.4 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain GNAT_acetyltr_2 PF13718.6 ORX63145.1 - 0.3 10.5 1.8 0.96 8.8 0.0 2.2 2 0 0 2 2 2 0 GNAT acetyltransferase 2 EB1 PF03271.17 ORX63146.1 - 1.3e-09 38.1 0.3 3.1e-09 36.9 0.3 1.6 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 ORX63146.1 - 1.6e-05 25.1 0.1 3.5e-05 23.9 0.1 1.6 2 0 0 2 2 2 1 Calponin homology (CH) domain Suppressor_APC PF11414.8 ORX63146.1 - 0.0028 17.7 0.0 0.0059 16.6 0.0 1.5 1 0 0 1 1 1 1 Adenomatous polyposis coli tumour suppressor protein OAS1_C PF10421.9 ORX63146.1 - 0.013 15.0 0.2 0.024 14.1 0.2 1.4 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Bromodomain PF00439.25 ORX63147.1 - 2.9e-47 158.6 2.3 8.6e-23 80.2 0.2 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 ORX63147.1 - 4.1e-22 78.1 0.2 1e-21 76.9 0.2 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation FlxA PF14282.6 ORX63147.1 - 0.0014 18.6 6.9 0.0014 18.6 6.9 3.4 5 0 0 5 5 5 2 FlxA-like protein EFhand_Ca_insen PF08726.10 ORX63147.1 - 0.45 10.6 1.9 6.4 6.9 0.0 3.2 3 0 0 3 3 3 0 Ca2+ insensitive EF hand DUF2802 PF10975.8 ORX63147.1 - 1.4 9.1 6.5 8.7 6.5 0.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) MerR-DNA-bind PF09278.11 ORX63147.1 - 2 9.0 4.6 8 7.1 0.7 3.0 3 0 0 3 3 3 0 MerR, DNA binding E2F_CC-MB PF16421.5 ORX63147.1 - 2.9 8.3 6.3 8.2 6.9 0.0 3.4 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain DUF4451 PF14616.6 ORX63148.1 - 1.8e-22 79.8 3.4 1.8e-22 79.8 3.4 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4451) Homeodomain PF00046.29 ORX63149.1 - 6.3e-15 54.8 7.3 1.2e-14 53.9 7.3 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ORX63149.1 - 0.0063 16.4 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Homeobox KN domain HTH_23 PF13384.6 ORX63149.1 - 0.016 15.0 0.1 0.033 14.0 0.1 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Ubiquitin_2 PF14560.6 ORX63151.1 - 1.1e-25 89.9 0.0 3.2e-25 88.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-like domain CAP_GLY PF01302.25 ORX63151.1 - 1.1e-25 89.4 1.0 1.6e-25 88.9 0.4 1.5 2 0 0 2 2 2 1 CAP-Gly domain ubiquitin PF00240.23 ORX63151.1 - 0.00044 19.9 1.1 0.002 17.9 0.0 2.4 3 0 0 3 3 3 1 Ubiquitin family Caps_synth_GfcC PF06251.11 ORX63151.1 - 0.048 13.3 0.3 0.07 12.7 0.3 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC QueH PF02677.14 ORX63151.1 - 0.14 12.2 0.6 0.22 11.6 0.6 1.2 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH B-block_TFIIIC PF04182.12 ORX63152.1 - 9.4e-10 38.5 0.2 1.1e-08 35.1 0.0 2.5 2 0 0 2 2 2 1 B-block binding subunit of TFIIIC HTH_20 PF12840.7 ORX63152.1 - 0.00011 22.2 0.1 0.012 15.6 0.1 3.2 2 0 0 2 2 2 1 Helix-turn-helix domain Myb_DNA-binding PF00249.31 ORX63152.1 - 0.00036 20.7 0.0 0.001 19.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain MarR_2 PF12802.7 ORX63152.1 - 0.00061 19.6 0.0 0.0051 16.7 0.0 2.7 1 0 0 1 1 1 1 MarR family MarR PF01047.22 ORX63152.1 - 0.00091 19.1 0.0 0.051 13.5 0.0 3.3 3 0 0 3 3 3 1 MarR family RNA_pol_Rpc34 PF05158.12 ORX63152.1 - 0.0098 15.3 0.0 0.025 13.9 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit ADP_PFK_GK PF04587.15 ORX63152.1 - 0.023 13.3 0.0 0.04 12.5 0.0 1.3 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Myb_DNA-bind_6 PF13921.6 ORX63152.1 - 0.052 13.8 0.2 0.26 11.6 0.2 2.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain HTH_IclR PF09339.10 ORX63152.1 - 0.29 11.0 1.2 2.3 8.1 0.1 3.2 2 1 0 2 2 2 0 IclR helix-turn-helix domain Orn_Arg_deC_N PF02784.16 ORX63153.1 - 3.8e-80 268.8 0.0 4.9e-80 268.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ORX63153.1 - 2.6e-18 66.0 0.0 3.2e-18 65.8 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 ORX63153.1 - 0.0082 15.6 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel polyprenyl_synt PF00348.17 ORX63154.1 - 4.8e-35 120.9 1.3 1.3e-34 119.5 0.3 1.9 2 0 0 2 2 2 1 Polyprenyl synthetase CTP_transf_like PF01467.26 ORX63155.1 - 2.7e-06 27.6 0.0 3.9e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like Diphthami_syn_2 PF01902.17 ORX63156.1 - 2.2e-44 151.6 0.4 6.1e-44 150.1 0.4 1.6 1 1 0 1 1 1 1 Diphthamide synthase Na_Ca_ex_C PF16494.5 ORX63156.1 - 0.017 15.5 0.0 0.029 14.8 0.0 1.4 1 0 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain tRNA_Me_trans PF03054.16 ORX63156.1 - 0.06 12.1 0.0 0.1 11.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase AICARFT_IMPCHas PF01808.18 ORX63157.1 - 1e-94 317.4 1.0 1.7e-94 316.6 1.0 1.4 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 ORX63157.1 - 3.2e-25 88.1 0.0 9.1e-25 86.7 0.0 1.8 1 0 0 1 1 1 1 MGS-like domain MIG-14_Wnt-bd PF06664.12 ORX63158.1 - 0.079 12.2 0.8 0.09 12.0 0.8 1.0 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion EF-hand_1 PF00036.32 ORX63159.1 - 3.8e-23 79.3 18.6 3.6e-06 26.1 1.7 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX63159.1 - 8.7e-20 71.0 9.1 1.8e-11 44.3 2.6 2.3 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ORX63159.1 - 2.8e-18 64.2 11.5 4.1e-05 23.2 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ORX63159.1 - 4.8e-15 54.3 20.4 4e-05 22.9 0.7 5.0 4 1 1 5 5 5 3 EF hand EF-hand_8 PF13833.6 ORX63159.1 - 2.4e-09 36.9 15.0 0.005 16.7 1.3 4.2 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ORX63159.1 - 5.2e-06 26.8 0.2 0.017 15.4 0.2 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ORX63159.1 - 0.0013 18.7 9.6 0.044 13.7 1.6 3.4 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ORX63159.1 - 0.029 14.7 0.4 1.4 9.3 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain Colicin_im PF03857.13 ORX63161.1 - 0.24 11.4 2.8 6.2 6.8 1.5 2.1 2 0 0 2 2 2 0 Colicin immunity protein OrfB_Zn_ribbon PF07282.11 ORX63162.1 - 7.3e-08 32.2 0.1 1e-07 31.8 0.1 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DUF4200 PF13863.6 ORX63163.1 - 0.0015 19.0 3.5 0.002 18.5 3.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Exonuc_VII_L PF02601.15 ORX63163.1 - 0.011 15.3 0.4 0.012 15.2 0.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BCAS2 PF05700.11 ORX63163.1 - 0.026 14.2 3.5 0.14 11.9 3.0 2.0 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Ntox28 PF15605.6 ORX63163.1 - 0.061 13.6 0.5 0.12 12.6 0.5 1.5 1 0 0 1 1 1 0 Bacterial toxin 28 FadA PF09403.10 ORX63163.1 - 0.085 13.3 5.5 0.2 12.1 5.5 1.7 1 1 0 1 1 1 0 Adhesion protein FadA CdvA PF18822.1 ORX63163.1 - 0.15 11.9 3.1 0.37 10.6 0.2 2.4 2 1 1 3 3 3 0 CdvA-like coiled-coil domain Phage_Gp23 PF10669.9 ORX63163.1 - 0.32 11.3 2.6 0.47 10.8 2.6 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) OmpH PF03938.14 ORX63163.1 - 0.42 11.0 7.8 0.68 10.3 7.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Tmemb_cc2 PF10267.9 ORX63163.1 - 7.6 5.6 10.2 1.8 7.6 5.9 1.7 1 1 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein Pkinase PF00069.25 ORX63164.1 - 9.8e-51 172.6 0.3 1.7e-50 171.9 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63164.1 - 1.7e-38 132.4 0.3 2.8e-38 131.7 0.3 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 ORX63164.1 - 0.00012 22.2 0.1 0.00028 21.1 0.1 1.6 1 0 0 1 1 1 1 Oxidative-stress-responsive kinase 1 C-terminal domain Pkinase_fungal PF17667.1 ORX63164.1 - 0.059 12.1 0.0 0.15 10.8 0.0 1.6 1 0 0 1 1 1 0 Fungal protein kinase GH114_assoc PF14741.6 ORX63164.1 - 0.12 12.6 0.1 1.6 8.9 0.1 2.6 2 0 0 2 2 2 0 N-terminal glycosyl-hydrolase-114-associated domain CRAL_TRIO PF00650.20 ORX63165.1 - 2.8e-40 137.6 0.1 5.9e-40 136.6 0.0 1.5 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 ORX63165.1 - 8.5e-09 35.5 2.1 2e-08 34.3 2.1 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 ORX63165.1 - 2e-07 31.3 0.0 3e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain ATP-synt_ab PF00006.25 ORX63166.1 - 1e-71 241.0 0.0 1.5e-71 240.5 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 ORX63166.1 - 1.3e-46 158.0 0.0 2.3e-46 157.2 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 ORX63166.1 - 3.3e-20 72.4 1.1 8.5e-20 71.1 1.1 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 ORX63166.1 - 0.02 15.1 0.2 0.059 13.5 0.2 1.9 1 1 0 1 1 1 0 HAS barrel domain VirC2 PF07181.11 ORX63166.1 - 0.069 12.6 0.2 0.24 10.9 0.1 1.8 2 0 0 2 2 2 0 VirC2 protein Nop16 PF09420.10 ORX63167.1 - 2.9e-55 187.6 6.8 3.3e-55 187.4 6.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 DUF4142 PF13628.6 ORX63167.1 - 0.083 13.1 0.2 0.083 13.1 0.2 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4142) OMPdecase PF00215.24 ORX63168.1 - 5.7e-75 251.8 0.1 6.6e-75 251.6 0.1 1.0 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-C2H2 PF00096.26 ORX63169.1 - 8.1e-12 44.9 24.0 7.7e-07 29.2 0.8 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ORX63169.1 - 2.3e-07 31.1 22.2 0.0011 19.6 0.2 4.4 5 0 0 5 5 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ORX63169.1 - 0.0002 21.6 21.0 0.06 13.8 0.4 4.5 3 1 1 4 4 4 3 Zinc-finger double domain zf-C2H2_6 PF13912.6 ORX63169.1 - 0.00093 19.1 6.2 0.82 9.7 0.0 3.3 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_8 PF15909.5 ORX63169.1 - 0.0025 18.1 4.4 0.0086 16.4 4.4 2.0 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-met PF12874.7 ORX63169.1 - 0.012 16.0 5.5 0.11 12.9 0.3 3.4 4 0 0 4 4 3 0 Zinc-finger of C2H2 type zf-Di19 PF05605.12 ORX63169.1 - 0.076 13.3 12.7 0.95 9.8 8.9 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 ORX63169.1 - 0.41 11.0 3.6 19 5.7 0.1 2.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ORX63169.1 - 0.85 10.0 8.0 25 5.3 6.8 2.7 1 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 ORX63169.1 - 1.3 8.9 8.4 1.5 8.7 0.5 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain C5HCH PF17982.1 ORX63169.1 - 3.3 7.9 7.6 9.5 6.5 0.4 3.3 3 0 0 3 3 3 0 NSD Cys-His rich domain zf-CHY PF05495.12 ORX63169.1 - 6 7.4 10.1 5.5 7.5 6.8 2.4 1 1 1 2 2 2 0 CHY zinc finger FYVE PF01363.21 ORX63169.1 - 9.8 6.4 10.2 2.8 8.2 5.6 2.3 1 1 1 2 2 2 0 FYVE zinc finger Pkinase PF00069.25 ORX63170.1 - 3.1e-62 210.3 0.0 5.8e-62 209.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63170.1 - 6.9e-34 117.3 0.0 1.3e-33 116.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C1_1 PF00130.22 ORX63170.1 - 9.5e-20 70.2 26.5 3e-11 43.0 9.9 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) HR1 PF02185.16 ORX63170.1 - 1.3e-10 41.2 9.2 1e-05 25.5 2.5 2.5 2 0 0 2 2 2 2 Hr1 repeat Pkinase_C PF00433.24 ORX63170.1 - 1.8e-09 38.1 0.1 7e-09 36.2 0.1 2.1 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 ORX63170.1 - 9.4e-07 29.1 0.0 1.7e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain Kinase-like PF14531.6 ORX63170.1 - 0.0055 16.1 0.0 0.019 14.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ORX63170.1 - 0.0068 15.4 0.0 0.012 14.6 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ORX63170.1 - 0.027 14.1 0.0 3.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ORX63170.1 - 0.08 11.7 0.0 0.16 10.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase PI3_PI4_kinase PF00454.27 ORX63170.1 - 0.19 11.5 0.6 3.1 7.5 0.0 2.5 3 0 0 3 3 3 0 Phosphatidylinositol 3- and 4-kinase C1_2 PF03107.16 ORX63170.1 - 0.38 11.1 22.7 0.67 10.3 8.6 2.6 2 0 0 2 2 2 0 C1 domain Spc7 PF08317.11 ORX63171.1 - 0.0054 15.7 7.6 0.0061 15.5 6.4 1.5 1 1 1 2 2 2 1 Spc7 kinetochore protein zf-C4H2 PF10146.9 ORX63171.1 - 0.01 16.2 3.7 0.01 16.2 3.7 1.9 1 1 1 2 2 2 0 Zinc finger-containing protein bZIP_C PF12498.8 ORX63171.1 - 0.02 15.9 0.8 0.048 14.7 0.8 1.7 1 0 0 1 1 1 0 Basic leucine-zipper C terminal HAP1_N PF04849.13 ORX63171.1 - 0.044 13.0 14.0 0.11 11.6 5.1 2.1 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF724 PF05266.14 ORX63171.1 - 0.21 11.4 5.8 0.52 10.1 2.0 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF724) SKA1 PF07160.12 ORX63171.1 - 0.29 11.0 9.0 0.96 9.3 2.6 2.1 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Macoilin PF09726.9 ORX63171.1 - 0.29 9.6 12.1 0.54 8.7 11.8 1.5 1 1 0 1 1 1 0 Macoilin family BRE1 PF08647.11 ORX63171.1 - 0.88 9.7 8.0 2 8.6 6.9 2.1 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1664 PF07889.12 ORX63171.1 - 1 9.4 7.8 3.6 7.6 0.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.13 ORX63171.1 - 2.6 8.8 6.5 2.4 8.9 3.3 2.2 1 1 1 2 2 2 0 Occludin homology domain Fib_alpha PF08702.10 ORX63171.1 - 2.6 8.2 9.7 0.76 10.0 2.1 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4763 PF15960.5 ORX63171.1 - 5.6 6.2 14.4 15 4.8 9.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) YabA PF06156.13 ORX63171.1 - 6.1 7.5 9.4 9.8 6.9 3.8 2.7 1 1 1 2 2 2 0 Initiation control protein YabA S36_mt PF10937.8 ORX63172.1 - 1.9e-11 45.6 1.3 4.2e-06 28.3 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S36, mitochondrial Ribonuc_L-PSP PF01042.21 ORX63173.1 - 4.4e-45 152.6 0.7 5.1e-45 152.4 0.7 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP Phi29_Phage_SSB PF17427.2 ORX63173.1 - 0.069 13.3 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein Methyltransf_11 PF08241.12 ORX63174.1 - 7.7e-21 74.6 0.0 1.5e-20 73.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Sterol_MT_C PF08498.10 ORX63174.1 - 3.6e-19 68.8 0.0 8.1e-19 67.7 0.0 1.6 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_25 PF13649.6 ORX63174.1 - 3.7e-19 69.2 0.0 8.3e-19 68.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ORX63174.1 - 8e-18 64.7 0.0 1.2e-17 64.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ORX63174.1 - 4.3e-12 45.9 0.0 6e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 ORX63174.1 - 5.3e-11 42.6 0.0 8.6e-11 41.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ORX63174.1 - 2.5e-09 37.8 0.0 7.2e-09 36.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ORX63174.1 - 4.6e-09 36.0 0.0 7.1e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 ORX63174.1 - 6.5e-05 22.5 0.0 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ORX63174.1 - 0.00033 20.3 0.1 0.00051 19.7 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_32 PF13679.6 ORX63174.1 - 0.0041 17.1 0.0 0.0055 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ORX63174.1 - 0.0083 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_2 PF00891.18 ORX63174.1 - 0.024 13.9 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_8 PF05148.15 ORX63174.1 - 0.051 13.4 0.1 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 Hypothetical methyltransferase Methyltransf_9 PF08003.11 ORX63174.1 - 0.066 12.1 0.0 0.099 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) FtsJ PF01728.19 ORX63174.1 - 0.075 13.1 0.0 0.13 12.4 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase PCMT PF01135.19 ORX63174.1 - 0.18 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) RRM_1 PF00076.22 ORX63175.1 - 5.1e-35 119.1 0.4 2.4e-21 75.3 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ORX63175.1 - 6.3e-05 22.8 0.0 0.1 12.5 0.0 2.6 2 1 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 ORX63175.1 - 0.0047 17.0 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif DbpA PF03880.15 ORX63175.1 - 0.013 15.5 0.0 7.6 6.6 0.0 2.8 2 0 0 2 2 2 0 DbpA RNA binding domain RRM_5 PF13893.6 ORX63175.1 - 0.12 12.0 0.0 1.1 8.9 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ORX63175.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif APP_amyloid PF10515.9 ORX63175.1 - 0.23 12.0 0.7 0.78 10.3 0.2 2.2 2 0 0 2 2 2 0 Beta-amyloid precursor protein C-terminus Mpp10 PF04006.12 ORX63175.1 - 0.35 9.3 43.8 0.5 8.8 43.8 1.1 1 0 0 1 1 1 0 Mpp10 protein PHO4 PF01384.20 ORX63176.1 - 0.0018 17.4 2.3 0.002 17.2 2.3 1.2 1 0 0 1 1 1 1 Phosphate transporter family EXS PF03124.14 ORX63177.1 - 2.4e-93 313.1 26.6 2.7e-93 312.9 26.6 1.0 1 0 0 1 1 1 1 EXS family UCR_UQCRX_QCR9 PF05365.12 ORX63178.1 - 3.4e-30 103.8 3.7 3.8e-30 103.6 3.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like G-alpha PF00503.20 ORX63179.1 - 1.3e-111 373.2 3.3 1.5e-111 373.0 3.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ORX63179.1 - 1.9e-16 60.0 0.5 1.2e-09 37.8 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ORX63179.1 - 0.00066 19.9 0.2 0.054 13.7 0.1 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ORX63179.1 - 0.0025 17.2 2.8 0.65 9.3 0.1 2.4 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_24 PF13479.6 ORX63179.1 - 0.046 13.5 0.0 0.085 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain UNC-50 PF05216.13 ORX63180.1 - 1.4e-90 302.7 20.5 1.6e-90 302.5 20.5 1.0 1 0 0 1 1 1 1 UNC-50 family Hid1 PF12722.7 ORX63181.1 - 5.9e-224 745.8 0.1 2.3e-192 641.3 0.0 2.1 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 ORX63181.1 - 1.8e-123 413.2 0.0 2.3e-123 412.8 0.0 1.0 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein Cnd3 PF12719.7 ORX63182.1 - 4.2e-74 249.4 4.2 1.6e-72 244.2 2.2 2.7 2 0 0 2 2 2 2 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 ORX63182.1 - 3.6e-12 46.5 1.5 5.6e-06 26.7 0.2 4.7 3 2 3 6 6 6 3 HEAT repeats HEAT PF02985.22 ORX63182.1 - 1.8e-09 37.0 1.1 0.61 10.5 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat Cnd1 PF12717.7 ORX63182.1 - 3.3e-06 27.2 1.9 0.0033 17.5 0.2 3.9 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ORX63182.1 - 0.00041 19.0 0.2 0.29 9.6 0.0 3.3 3 0 0 3 3 3 2 Adaptin N terminal region HEAT_EZ PF13513.6 ORX63182.1 - 0.0062 17.0 0.6 3.1 8.4 0.1 3.8 4 0 0 4 4 4 1 HEAT-like repeat DUF2052 PF09747.9 ORX63182.1 - 0.0077 16.4 0.4 0.0077 16.4 0.4 1.7 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) Cohesin_HEAT PF12765.7 ORX63182.1 - 0.035 14.4 1.5 4.9 7.5 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion Pil1 PF13805.6 ORX63183.1 - 7.3e-32 110.9 0.1 1.2e-31 110.2 0.1 1.3 1 0 0 1 1 1 1 Eisosome component PIL1 CCDC-167 PF15188.6 ORX63183.1 - 0.027 14.8 3.5 0.05 13.9 3.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF3584 PF12128.8 ORX63183.1 - 0.029 11.9 1.2 0.037 11.5 1.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FTA4 PF13093.6 ORX63183.1 - 0.033 14.1 2.5 0.053 13.4 2.5 1.3 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 HHH_8 PF14716.6 ORX63183.1 - 0.039 14.3 0.9 0.13 12.7 1.0 1.8 2 0 0 2 2 2 0 Helix-hairpin-helix domain Exonuc_VII_L PF02601.15 ORX63183.1 - 0.18 11.3 0.6 0.25 10.9 0.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4672 PF15716.5 ORX63183.1 - 0.2 11.3 2.4 0.37 10.4 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) RHH_7 PF16777.5 ORX63184.1 - 0.035 14.5 0.0 0.041 14.3 0.0 1.1 1 0 0 1 1 1 0 Transcriptional regulator, RHH-like, CopG SplA PF11132.8 ORX63186.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator protein (SplA) DUF3349 PF11829.8 ORX63186.1 - 0.11 13.3 0.0 0.25 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) Bin3 PF06859.12 ORX63187.1 - 2e-38 131.4 0.0 3e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 Bicoid-interacting protein 3 (Bin3) Methyltransf_31 PF13847.6 ORX63187.1 - 3.2e-13 49.8 0.0 1.1e-08 35.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ORX63187.1 - 1.8e-12 47.4 0.0 2.5e-12 46.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ORX63187.1 - 2.7e-10 40.8 0.0 5.1e-06 27.1 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_12 PF08242.12 ORX63187.1 - 1.1e-08 35.7 0.0 0.0014 19.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ORX63187.1 - 4e-06 27.4 0.0 0.025 15.2 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain MTS PF05175.14 ORX63187.1 - 4.5e-06 26.3 0.0 7.3e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.20 ORX63187.1 - 2.9e-05 23.5 0.0 0.0082 15.5 0.0 2.1 2 0 0 2 2 2 2 Mycolic acid cyclopropane synthetase PrmA PF06325.13 ORX63187.1 - 5.4e-05 22.7 0.0 0.00013 21.4 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 ORX63187.1 - 0.00013 21.9 0.0 0.00024 21.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ORX63187.1 - 0.00074 18.5 0.0 0.75 8.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1698) Spermine_synth PF01564.17 ORX63187.1 - 0.003 17.0 0.0 0.62 9.4 0.0 2.1 2 0 0 2 2 2 2 Spermine/spermidine synthase domain Methyltransf_32 PF13679.6 ORX63187.1 - 0.013 15.4 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.17 ORX63187.1 - 0.017 14.6 0.0 0.072 12.6 0.0 1.9 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_PK PF05891.12 ORX63187.1 - 0.026 14.1 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 AdoMet dependent proline di-methyltransferase PCMT PF01135.19 ORX63187.1 - 0.03 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 ORX63187.1 - 0.17 11.1 0.0 0.51 9.6 0.0 1.6 2 0 0 2 2 2 0 O-methyltransferase domain Cid2 PF09774.9 ORX63188.1 - 6.8e-19 68.8 6.2 2.1e-17 64.0 6.2 2.3 1 1 0 1 1 1 1 Caffeine-induced death protein 2 Aa_trans PF01490.18 ORX63189.1 - 7.3e-62 209.4 23.8 1.2e-61 208.7 23.8 1.3 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Phosphorylase PF00343.20 ORX63190.1 - 0 1031.4 0.0 0 1031.1 0.0 1.1 1 0 0 1 1 1 1 Carbohydrate phosphorylase Spo7 PF03907.13 ORX63190.1 - 0.043 13.3 0.0 0.077 12.5 0.0 1.4 1 0 0 1 1 1 0 Spo7-like protein LepB_N PF18640.1 ORX63190.1 - 0.061 12.9 0.1 0.17 11.5 0.1 1.7 1 0 0 1 1 1 0 LepB N-terminal domain SKICH PF17751.1 ORX63190.1 - 0.1 13.2 0.1 0.38 11.3 0.1 1.9 1 1 0 1 1 1 0 SKICH domain DUF3417 PF11897.8 ORX63190.1 - 1.1 9.7 3.9 2.5 8.6 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3417) Pex24p PF06398.11 ORX63191.1 - 4.3e-35 121.4 0.1 6.6e-35 120.8 0.1 1.3 1 1 0 1 1 1 1 Integral peroxisomal membrane peroxin C1_1 PF00130.22 ORX63191.1 - 1.1e-10 41.3 4.9 2.2e-10 40.2 4.9 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING_9 PF13901.6 ORX63191.1 - 0.036 14.0 2.0 0.086 12.8 2.0 1.5 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon C1_2 PF03107.16 ORX63191.1 - 0.078 13.3 1.0 0.17 12.2 1.0 1.6 1 0 0 1 1 1 0 C1 domain PHD PF00628.29 ORX63191.1 - 0.93 9.4 5.1 1.9 8.4 5.1 1.5 1 0 0 1 1 1 0 PHD-finger adh_short PF00106.25 ORX63192.1 - 1.1e-43 148.9 6.8 1.4e-43 148.6 6.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ORX63192.1 - 6.5e-43 147.0 5.8 7.7e-43 146.7 5.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ORX63192.1 - 3.8e-08 33.4 4.4 2e-07 31.1 4.4 2.2 1 1 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ORX63192.1 - 0.00088 18.4 0.6 0.0019 17.3 0.6 1.8 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ORX63192.1 - 0.023 14.2 1.1 0.11 12.0 1.0 2.1 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_2 PF03446.15 ORX63192.1 - 0.065 13.4 2.8 3.8 7.7 0.3 3.1 2 2 1 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase EF-hand_1 PF00036.32 ORX63193.1 - 9.5e-38 125.0 14.2 7.7e-10 37.6 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ORX63193.1 - 1e-32 112.4 7.8 1.2e-17 64.2 3.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ORX63193.1 - 2.2e-29 101.1 13.9 1.3e-15 57.0 1.2 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 ORX63193.1 - 2.6e-28 95.5 13.6 4e-09 35.7 0.1 4.9 3 1 2 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ORX63193.1 - 8.9e-26 88.2 12.5 6.1e-07 28.7 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ORX63193.1 - 8.6e-14 51.6 0.2 7.6e-08 32.6 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ORX63193.1 - 4.8e-10 39.3 3.3 0.00025 21.0 0.1 2.5 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ORX63193.1 - 2.2e-08 34.4 2.1 0.00047 20.5 0.8 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1296 PF06972.11 ORX63193.1 - 0.0031 17.6 0.2 1.8 8.7 0.1 2.9 3 1 1 4 4 3 1 Protein of unknown function (DUF1296) Dockerin_1 PF00404.18 ORX63193.1 - 0.0098 16.1 9.6 0.15 12.3 0.8 2.9 1 1 3 4 4 4 2 Dockerin type I domain Fe_hyd_lg_C PF02906.14 ORX63193.1 - 0.012 15.4 0.5 0.41 10.3 0.0 2.0 1 1 1 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain EF-hand_11 PF08976.11 ORX63193.1 - 0.013 16.4 0.2 0.042 14.7 0.1 1.7 1 1 1 2 2 2 0 EF-hand domain LXG PF04740.12 ORX63193.1 - 0.022 14.5 0.4 0.065 12.9 0.1 1.8 1 1 1 2 2 2 0 LXG domain of WXG superfamily EF-hand_14 PF17959.1 ORX63193.1 - 0.026 14.9 0.3 0.17 12.2 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain Caleosin PF05042.13 ORX63193.1 - 0.033 14.1 0.8 4.1 7.3 0.0 3.1 1 1 2 3 3 3 0 Caleosin related protein UPF0253 PF06786.12 ORX63193.1 - 0.045 14.0 0.0 0.086 13.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0253) DUF5580 PF17743.1 ORX63193.1 - 0.05 12.2 0.0 0.051 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) DUF3349 PF11829.8 ORX63193.1 - 0.055 14.2 0.2 15 6.4 0.0 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) UPF0154 PF03672.13 ORX63193.1 - 0.07 13.2 0.0 3 8.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) Adenine_glyco PF03352.13 ORX63193.1 - 0.082 12.7 0.0 4.5 7.0 0.0 2.0 1 1 1 2 2 2 0 Methyladenine glycosylase RNA_pol_Rpb4 PF03874.16 ORX63193.1 - 0.095 13.0 0.8 0.22 11.9 0.8 1.6 1 1 0 1 1 1 0 RNA polymerase Rpb4 RPN13_C PF16550.5 ORX63193.1 - 0.1 12.8 0.0 12 6.1 0.0 2.3 2 0 0 2 2 2 0 UCH-binding domain DUF533 PF04391.12 ORX63193.1 - 0.22 11.1 0.9 5.1 6.6 0.2 2.6 2 2 1 3 3 3 0 Protein of unknown function (DUF533) Aminotran_3 PF00202.21 ORX63194.1 - 4.2e-119 397.8 0.0 4.8e-119 397.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III FAD_oxidored PF12831.7 ORX63194.1 - 0.079 12.3 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase CN_hydrolase PF00795.22 ORX63195.1 - 2.9e-22 79.3 0.0 5.4e-22 78.4 0.0 1.5 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase RNA_pol_Rpc34 PF05158.12 ORX63196.1 - 2.2e-88 296.8 0.0 2.8e-88 296.6 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.12 ORX63196.1 - 0.059 13.5 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC Cg6151-P PF10233.9 ORX63197.1 - 5.7e-29 100.7 14.3 6.8e-29 100.5 14.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P Fe-S_biosyn PF01521.20 ORX63198.1 - 2e-09 37.6 0.1 2.3e-09 37.4 0.1 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis Flg_bbr_C PF06429.13 ORX63198.1 - 0.046 13.9 0.0 0.063 13.4 0.0 1.3 1 0 0 1 1 1 0 Flagellar basal body rod FlgEFG protein C-terminal Mito_carr PF00153.27 ORX63199.1 - 2.1e-69 229.5 1.7 3.9e-24 84.4 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 ORX63199.1 - 0.02 14.1 0.0 0.036 13.3 0.0 1.3 1 0 0 1 1 1 0 Fuseless ACAS_N PF16177.5 ORX63199.1 - 0.027 14.4 1.6 0.05 13.5 1.6 1.4 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus GTP_EFTU PF00009.27 ORX63200.1 - 6.6e-66 221.6 0.1 9.4e-66 221.1 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ORX63200.1 - 3.9e-31 107.3 0.0 1.5e-30 105.5 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 ORX63200.1 - 8e-23 80.3 0.0 1.9e-22 79.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ORX63200.1 - 3.7e-13 49.4 0.0 8.5e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ORX63200.1 - 8.5e-12 45.3 0.7 2.1e-11 44.0 0.1 2.0 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ORX63200.1 - 7.9e-05 22.7 0.1 0.00018 21.6 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ORX63200.1 - 0.042 13.6 0.0 0.14 11.8 0.0 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Nuc_sug_transp PF04142.15 ORX63201.1 - 2.7e-68 230.5 5.5 3.3e-68 230.2 5.5 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ORX63201.1 - 4.5e-07 30.1 17.3 5.1e-06 26.7 3.3 2.2 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ORX63201.1 - 3.7e-06 26.4 3.9 5e-06 26.0 3.9 1.2 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport EmrE PF13536.6 ORX63201.1 - 0.00061 19.5 3.2 0.00079 19.1 3.2 1.3 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter UAA PF08449.11 ORX63201.1 - 0.0033 16.7 1.8 0.0033 16.7 1.8 2.0 1 1 1 2 2 2 2 UAA transporter family CRT-like PF08627.10 ORX63201.1 - 0.0047 15.9 1.8 0.007 15.4 1.8 1.2 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like Tropomyosin_1 PF12718.7 ORX63203.1 - 8.3e-19 68.2 23.2 7.9e-13 48.8 7.9 2.1 1 1 1 2 2 2 2 Tropomyosin like Tropomyosin PF00261.20 ORX63203.1 - 3.3e-07 29.9 19.9 8e-07 28.7 19.9 1.6 1 1 0 1 1 1 1 Tropomyosin XhlA PF10779.9 ORX63203.1 - 2.3e-05 24.5 15.8 0.011 15.9 0.5 3.1 2 1 1 3 3 3 3 Haemolysin XhlA AAA_13 PF13166.6 ORX63203.1 - 0.00022 20.0 11.2 0.00024 19.9 11.2 1.0 1 0 0 1 1 1 1 AAA domain TPR_MLP1_2 PF07926.12 ORX63203.1 - 0.0005 20.1 18.2 0.0016 18.5 13.5 2.0 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Prefoldin_2 PF01920.20 ORX63203.1 - 0.00061 19.7 19.3 0.032 14.2 1.7 3.1 1 1 2 3 3 3 2 Prefoldin subunit EzrA PF06160.12 ORX63203.1 - 0.0012 17.2 15.2 0.002 16.4 15.2 1.4 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 ORX63203.1 - 0.0016 18.9 6.5 0.13 12.8 0.1 2.5 1 1 1 2 2 2 1 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ORX63203.1 - 0.0018 18.3 7.8 0.03 14.3 2.8 2.1 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) MscS_porin PF12795.7 ORX63203.1 - 0.0026 17.3 16.7 0.016 14.7 16.7 1.8 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain IFT57 PF10498.9 ORX63203.1 - 0.0028 16.7 10.4 0.0036 16.3 10.4 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 TMF_DNA_bd PF12329.8 ORX63203.1 - 0.0036 17.3 19.6 0.094 12.7 8.1 2.9 1 1 0 2 2 2 2 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 ORX63203.1 - 0.0053 15.7 18.8 0.012 14.5 18.8 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein ERM PF00769.19 ORX63203.1 - 0.0056 16.5 19.5 0.021 14.6 15.3 2.1 1 1 1 2 2 2 1 Ezrin/radixin/moesin family FlaC_arch PF05377.11 ORX63203.1 - 0.0056 17.1 10.9 0.42 11.1 0.6 3.2 1 1 1 3 3 3 2 Flagella accessory protein C (FlaC) ATG16 PF08614.11 ORX63203.1 - 0.0056 16.9 20.0 0.077 13.2 20.1 1.9 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) ADIP PF11559.8 ORX63203.1 - 0.0067 16.5 16.1 0.58 10.2 3.9 2.4 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding DUF5082 PF16888.5 ORX63203.1 - 0.0077 16.5 9.4 0.017 15.4 9.4 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF5082) DUF4763 PF15960.5 ORX63203.1 - 0.0078 15.5 7.4 0.0093 15.3 6.4 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4763) Laminin_II PF06009.12 ORX63203.1 - 0.0083 16.1 10.2 0.16 12.0 1.3 2.5 1 1 0 2 2 2 1 Laminin Domain II CENP-F_leu_zip PF10473.9 ORX63203.1 - 0.0086 16.1 20.5 0.044 13.8 3.7 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 ORX63203.1 - 0.009 15.6 13.9 0.014 15.0 8.0 2.0 1 1 1 2 2 2 1 Intermediate filament protein FliD_C PF07195.12 ORX63203.1 - 0.0099 15.3 7.2 0.23 10.9 0.5 2.1 1 1 1 2 2 2 1 Flagellar hook-associated protein 2 C-terminus DUF4407 PF14362.6 ORX63203.1 - 0.01 15.2 10.3 0.013 14.9 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med9 PF07544.13 ORX63203.1 - 0.01 15.9 8.4 0.14 12.3 0.1 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 GrpE PF01025.19 ORX63203.1 - 0.012 15.2 17.5 0.17 11.5 2.5 2.3 1 1 0 2 2 2 0 GrpE KELK PF15796.5 ORX63203.1 - 0.013 15.9 19.9 0.17 12.4 2.5 2.7 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF3287 PF11690.8 ORX63203.1 - 0.014 15.2 1.9 0.58 9.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) Vps5 PF09325.10 ORX63203.1 - 0.017 14.7 12.9 0.032 13.8 4.9 2.1 1 1 1 2 2 2 0 Vps5 C terminal like GAS PF13851.6 ORX63203.1 - 0.025 13.9 16.9 0.069 12.5 16.9 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DLP_helical PF18709.1 ORX63203.1 - 0.037 13.2 11.3 0.22 10.7 4.4 2.1 1 1 1 2 2 2 0 Dynamin-like helical domain DUF812 PF05667.11 ORX63203.1 - 0.039 12.9 15.4 0.21 10.5 8.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) BLOC1_2 PF10046.9 ORX63203.1 - 0.048 14.0 11.1 4.3 7.7 3.9 2.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Uso1_p115_C PF04871.13 ORX63203.1 - 0.05 14.0 19.3 11 6.4 19.3 2.1 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF724 PF05266.14 ORX63203.1 - 0.051 13.4 13.9 0.53 10.1 13.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DHR10 PF18595.1 ORX63203.1 - 0.053 13.6 20.6 0.79 9.8 11.7 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain HMMR_N PF15905.5 ORX63203.1 - 0.055 12.9 17.0 0.067 12.7 17.0 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal YkyA PF10368.9 ORX63203.1 - 0.056 13.1 18.6 0.37 10.4 18.6 2.5 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein Sec34 PF04136.15 ORX63203.1 - 0.062 13.2 9.1 2.5 8.0 5.4 2.1 1 1 1 2 2 2 0 Sec34-like family DUF4200 PF13863.6 ORX63203.1 - 0.068 13.6 19.7 0.1 13.0 17.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) DUF16 PF01519.16 ORX63203.1 - 0.079 13.5 11.9 0.88 10.1 3.9 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF3584 PF12128.8 ORX63203.1 - 0.084 10.4 14.6 0.11 10.0 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TMCO5 PF14992.6 ORX63203.1 - 0.085 12.4 14.3 0.096 12.2 14.3 1.1 1 0 0 1 1 1 0 TMCO5 family ZapB PF06005.12 ORX63203.1 - 0.086 13.3 16.7 0.58 10.6 8.0 2.5 1 1 0 2 2 2 0 Cell division protein ZapB KASH_CCD PF14662.6 ORX63203.1 - 0.099 12.5 17.1 0.14 12.0 17.1 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Tektin PF03148.14 ORX63203.1 - 0.1 11.4 13.1 0.14 10.9 13.1 1.2 1 0 0 1 1 1 0 Tektin family Snapin_Pallidin PF14712.6 ORX63203.1 - 0.12 12.8 8.1 2.1 8.8 3.4 2.4 1 1 1 2 2 2 0 Snapin/Pallidin Lebercilin PF15619.6 ORX63203.1 - 0.12 12.0 18.4 0.41 10.3 18.4 1.7 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.15 ORX63203.1 - 0.12 12.8 14.4 0.26 11.7 12.7 1.8 1 1 0 1 1 1 0 Fez1 bZIP_1 PF00170.21 ORX63203.1 - 0.13 12.4 15.3 0.93 9.6 0.9 3.2 1 1 2 3 3 3 0 bZIP transcription factor HrpB7 PF09486.10 ORX63203.1 - 0.13 12.6 13.2 0.22 11.9 13.2 1.4 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) T3SSipB PF16535.5 ORX63203.1 - 0.14 12.6 10.9 4.3 7.8 10.9 2.0 1 1 0 1 1 1 0 Type III cell invasion protein SipB FPP PF05911.11 ORX63203.1 - 0.15 10.2 16.6 0.29 9.3 16.6 1.5 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil Seryl_tRNA_N PF02403.22 ORX63203.1 - 0.16 12.2 17.1 1.3 9.3 1.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Pox_A11 PF05061.13 ORX63203.1 - 0.19 11.0 3.5 0.22 10.8 3.5 1.1 1 0 0 1 1 1 0 Poxvirus A11 Protein DUF948 PF06103.11 ORX63203.1 - 0.19 12.0 5.3 2.8 8.2 0.2 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 ORX63203.1 - 0.2 11.9 20.5 1.9 8.8 11.2 2.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain BRE1 PF08647.11 ORX63203.1 - 0.21 11.7 16.8 0.73 10.0 7.2 2.5 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase HOOK PF05622.12 ORX63203.1 - 0.23 9.6 16.6 0.24 9.5 16.6 1.0 1 0 0 1 1 1 0 HOOK protein Laminin_I PF06008.14 ORX63203.1 - 0.24 11.1 15.1 0.43 10.2 15.1 1.5 1 1 0 1 1 1 0 Laminin Domain I DUF4201 PF13870.6 ORX63203.1 - 0.27 11.0 15.5 3.5 7.3 7.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) WXG100 PF06013.12 ORX63203.1 - 0.27 11.5 6.9 26 5.1 3.9 3.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG IZUMO PF15005.6 ORX63203.1 - 0.28 11.7 6.8 0.36 11.3 6.8 1.3 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Baculo_PEP_C PF04513.12 ORX63203.1 - 0.28 11.2 4.9 1 9.4 4.2 1.9 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fmp27_WPPW PF10359.9 ORX63203.1 - 0.3 9.9 12.0 0.17 10.7 4.3 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain PspA_IM30 PF04012.12 ORX63203.1 - 0.3 10.6 15.7 0.48 10.0 15.6 1.4 1 1 0 1 1 1 0 PspA/IM30 family APG6_N PF17675.1 ORX63203.1 - 0.31 11.6 23.7 2 9.0 13.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Borrelia_P83 PF05262.11 ORX63203.1 - 0.31 9.5 15.7 0.36 9.3 15.7 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Exonuc_VII_L PF02601.15 ORX63203.1 - 0.33 10.5 7.9 0.37 10.3 7.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit LPP PF04728.13 ORX63203.1 - 0.35 11.3 7.2 7 7.1 0.1 3.2 1 1 2 3 3 3 0 Lipoprotein leucine-zipper DUF4472 PF14739.6 ORX63203.1 - 0.39 11.5 13.9 5.2 7.8 3.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) KLRAQ PF10205.9 ORX63203.1 - 0.4 11.0 11.7 0.22 11.7 9.3 1.7 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Mod_r PF07200.13 ORX63203.1 - 0.44 10.7 14.3 8.2 6.5 14.1 2.2 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Csm1_N PF18504.1 ORX63203.1 - 0.46 10.9 18.0 4.5 7.7 1.0 3.1 1 1 2 3 3 3 0 Csm1 N-terminal domain TMPIT PF07851.13 ORX63203.1 - 0.47 9.7 10.2 0.5 9.6 4.2 1.9 1 1 1 2 2 2 0 TMPIT-like protein Tup_N PF08581.10 ORX63203.1 - 0.5 10.7 11.6 0.44 10.9 5.3 2.2 1 1 1 2 2 2 0 Tup N-terminal DUF2203 PF09969.9 ORX63203.1 - 0.5 11.1 10.6 2.4 8.9 3.9 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF3450 PF11932.8 ORX63203.1 - 0.5 9.6 13.7 4.4 6.5 7.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF745 PF05335.13 ORX63203.1 - 0.52 10.0 11.0 1.1 9.0 4.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) COG2 PF06148.11 ORX63203.1 - 0.55 10.3 8.4 16 5.6 4.6 2.6 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Fib_alpha PF08702.10 ORX63203.1 - 0.56 10.4 8.3 2.2 8.5 3.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF2968 PF11180.8 ORX63203.1 - 0.57 9.8 10.9 3.6 7.2 4.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) SHE3 PF17078.5 ORX63203.1 - 0.65 9.7 13.0 3 7.5 0.8 2.0 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 CENP-Q PF13094.6 ORX63203.1 - 0.68 10.1 21.4 3.4 7.8 2.6 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit SlyX PF04102.12 ORX63203.1 - 0.86 10.3 10.6 3.5 8.3 5.2 2.9 1 1 2 3 3 3 0 SlyX Nsp1_C PF05064.13 ORX63203.1 - 0.89 9.4 12.1 3 7.7 5.3 2.1 1 1 1 2 2 2 0 Nsp1-like C-terminal region HAUS-augmin3 PF14932.6 ORX63203.1 - 0.94 9.0 14.8 0.58 9.7 10.1 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Lectin_N PF03954.14 ORX63203.1 - 0.95 9.2 8.0 2.2 8.1 4.0 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Prefoldin PF02996.17 ORX63203.1 - 0.95 9.4 15.9 9.2 6.2 2.1 3.3 1 1 1 3 3 3 0 Prefoldin subunit CRR7 PF12095.8 ORX63203.1 - 1.1 9.7 6.4 0.74 10.3 2.4 2.2 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Spc24 PF08286.11 ORX63203.1 - 1.1 9.5 15.3 2.8 8.2 0.6 2.7 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Fzo_mitofusin PF04799.13 ORX63203.1 - 1.2 8.7 9.6 4.6 6.8 4.0 2.5 1 1 2 3 3 3 0 fzo-like conserved region DUF641 PF04859.12 ORX63203.1 - 1.3 9.4 12.7 1.9 8.9 7.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CLZ PF16526.5 ORX63203.1 - 1.4 9.3 15.3 2.3 8.6 0.9 2.9 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BST2 PF16716.5 ORX63203.1 - 1.5 9.5 14.8 1.8 9.2 6.8 2.2 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF4988 PF16378.5 ORX63203.1 - 1.6 8.4 5.6 40 3.8 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function Nup54 PF13874.6 ORX63203.1 - 1.6 8.8 10.0 1.7 8.7 6.2 2.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF2461 PF09365.10 ORX63203.1 - 1.7 8.5 7.1 2.4 8.1 7.0 1.4 1 1 0 1 1 1 0 Conserved hypothetical protein (DUF2461) Vac_Fusion PF02346.16 ORX63203.1 - 1.8 8.3 6.7 9.4 5.9 0.6 2.8 1 1 3 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 MutS_IV PF05190.18 ORX63203.1 - 1.8 8.9 10.8 5.5 7.4 0.5 3.2 1 1 1 3 3 3 0 MutS family domain IV DUF334 PF03904.13 ORX63203.1 - 1.9 8.0 9.8 3.3 7.2 8.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF334) V_ATPase_I PF01496.19 ORX63203.1 - 1.9 6.3 9.2 2.3 6.0 9.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 ORX63203.1 - 2 8.3 18.7 0.57 10.0 4.7 3.1 1 1 3 4 4 4 0 Septum formation initiator Jnk-SapK_ap_N PF09744.9 ORX63203.1 - 2 8.6 18.5 7.3 6.8 7.6 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF5320 PF17253.2 ORX63203.1 - 2.2 9.4 13.4 2.2 9.4 4.4 3.2 2 2 1 3 3 3 0 Family of unknown function (DUF5320) Bacillus_HBL PF05791.11 ORX63203.1 - 2.3 8.0 9.8 1.6 8.5 3.8 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Syntaxin-6_N PF09177.11 ORX63203.1 - 2.4 8.7 10.7 11 6.7 4.6 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TMF_TATA_bd PF12325.8 ORX63203.1 - 2.5 8.4 16.6 3.6e+02 1.4 16.6 2.4 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Prominin PF05478.11 ORX63203.1 - 2.5 5.9 7.0 3.7 5.4 6.6 1.4 1 1 0 1 1 1 0 Prominin UPF0242 PF06785.11 ORX63203.1 - 2.6 8.1 17.8 13 5.8 17.8 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus NBP1 PF08537.10 ORX63203.1 - 2.8 7.3 14.5 1.8 7.9 7.7 2.0 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 FAM76 PF16046.5 ORX63203.1 - 3 7.1 11.0 0.8 9.0 6.8 1.7 1 1 1 2 2 2 0 FAM76 protein FapA PF03961.13 ORX63203.1 - 3 6.3 11.5 4.3 5.8 10.8 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF4795 PF16043.5 ORX63203.1 - 3.2 7.3 15.3 7.9 6.0 15.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Med4 PF10018.9 ORX63203.1 - 3.8 7.2 12.1 4.1 7.0 6.4 2.5 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4140 PF13600.6 ORX63203.1 - 4 7.9 17.7 2.7 8.5 1.6 3.1 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) CorA PF01544.18 ORX63203.1 - 4.3 6.6 8.0 5.4 6.2 8.0 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cluap1 PF10234.9 ORX63203.1 - 4.4 6.6 15.0 2.7 7.3 5.7 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 MtrG PF04210.13 ORX63203.1 - 4.7 7.1 6.0 2 8.3 0.5 2.7 1 1 2 3 3 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G PRKG1_interact PF15898.5 ORX63203.1 - 5 8.1 14.4 21 6.1 9.6 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain PspB PF06667.12 ORX63203.1 - 5.5 7.1 8.4 3.4 7.8 2.1 2.8 2 1 1 3 3 3 0 Phage shock protein B OEP PF02321.18 ORX63203.1 - 5.7 6.7 13.1 26 4.6 0.2 2.1 1 1 1 2 2 2 0 Outer membrane efflux protein Atg14 PF10186.9 ORX63203.1 - 6.1 5.8 12.8 16 4.4 12.8 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Rho_Binding PF08912.11 ORX63203.1 - 8.9 7.2 19.4 2.9 8.8 6.4 3.0 1 1 2 3 3 3 0 Rho Binding DUF4446 PF14584.6 ORX63203.1 - 8.9 6.3 9.9 6.7 6.7 0.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) JIP_LZII PF16471.5 ORX63203.1 - 9.6 6.5 15.1 4.5 7.5 0.4 2.9 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II GST_N_2 PF13409.6 ORX63204.1 - 1.2e-25 89.5 0.2 2.6e-23 82.1 0.0 2.3 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ORX63204.1 - 9.8e-13 47.9 0.0 2.3e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ORX63204.1 - 3.5e-08 33.5 0.0 1e-07 32.0 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ORX63204.1 - 4.5e-07 30.0 0.0 9.7e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ORX63204.1 - 0.0035 17.7 0.0 0.12 12.8 0.0 2.5 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain DUF3498 PF12004.8 ORX63205.1 - 0.3 10.2 2.4 0.45 9.7 2.3 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3498) La PF05383.17 ORX63206.1 - 3.4e-19 68.7 0.7 5.8e-19 67.9 0.7 1.4 1 0 0 1 1 1 1 La domain PPP5 PF08321.12 ORX63207.1 - 4e-32 110.4 4.0 2.9e-31 107.6 1.3 2.4 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 ORX63207.1 - 3e-30 106.2 0.2 4.5e-30 105.7 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_2 PF07719.17 ORX63207.1 - 3.4e-13 48.6 5.8 0.00043 20.2 0.3 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ORX63207.1 - 8.7e-12 44.3 11.3 0.00027 20.6 0.4 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ORX63207.1 - 1e-06 28.3 3.1 0.0023 17.6 0.0 3.8 3 1 1 4 4 4 2 TPR repeat TPR_9 PF13371.6 ORX63207.1 - 1.4e-05 25.2 0.0 0.00016 21.7 0.0 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ORX63207.1 - 2.5e-05 24.1 5.0 1.8 9.0 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ORX63207.1 - 6e-05 23.6 0.2 0.02 15.5 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ORX63207.1 - 0.00035 21.1 1.4 0.53 11.3 0.0 3.2 4 0 0 4 4 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ORX63207.1 - 0.00075 20.0 0.9 0.052 14.1 0.6 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ORX63207.1 - 0.0018 18.3 1.5 0.19 11.8 0.1 2.8 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ORX63207.1 - 0.0087 15.5 0.3 9.9 5.7 0.0 3.3 3 0 0 3 3 3 0 SHNi-TPR ANAPC3 PF12895.7 ORX63207.1 - 0.017 15.3 3.0 0.17 12.1 0.9 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ORX63207.1 - 0.04 14.2 2.9 2.9 8.3 0.8 3.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ORX63207.1 - 0.05 14.3 0.4 20 6.1 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_18 PF13512.6 ORX63207.1 - 0.053 13.6 2.5 1.5 8.9 0.4 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_20 PF14561.6 ORX63207.1 - 0.061 13.7 2.2 0.16 12.3 0.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ORX63207.1 - 0.17 12.3 1.7 4.6 7.8 0.2 3.6 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ORX63207.1 - 0.23 11.5 0.7 2.2 8.5 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat STIMATE PF12400.8 ORX63209.1 - 4.8e-37 127.3 6.8 6.9e-37 126.8 6.8 1.2 1 0 0 1 1 1 1 STIMATE family Ribosomal_S18 PF01084.20 ORX63210.1 - 1e-22 80.1 0.1 2.4e-22 78.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein S18 BDHCT_assoc PF16204.5 ORX63210.1 - 0.018 14.7 0.3 0.059 13.1 0.1 1.7 2 0 0 2 2 2 0 BDHCT-box associated domain on Bloom syndrome protein MTHFR PF02219.17 ORX63211.1 - 3.5e-115 384.3 0.0 5.6e-115 383.6 0.0 1.3 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase PIN_4 PF13638.6 ORX63211.1 - 0.049 13.9 0.0 0.088 13.1 0.0 1.3 1 0 0 1 1 1 0 PIN domain PIN_9 PF18477.1 ORX63211.1 - 0.061 13.6 0.1 0.29 11.5 0.0 2.0 1 1 1 2 2 2 0 PIN like domain Propeptide_C1 PF08127.13 ORX63211.1 - 0.063 13.2 0.3 14 5.6 0.1 3.1 3 0 0 3 3 3 0 Peptidase family C1 propeptide MCM_bind PF09739.9 ORX63213.1 - 5e-89 299.3 7.3 6.5e-81 272.5 3.9 2.0 1 1 1 2 2 2 2 Mini-chromosome maintenance replisome factor Complex1_LYR PF05347.15 ORX63213.1 - 0.16 12.0 0.1 0.3 11.2 0.1 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) Thioredoxin_9 PF14595.6 ORX63214.1 - 0.042 13.6 0.0 0.17 11.7 0.0 1.7 1 1 1 2 2 2 0 Thioredoxin Ipi1_N PF12333.8 ORX63215.1 - 1.4e-19 70.6 0.6 3.1e-18 66.2 0.2 3.2 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation TFIIF_alpha PF05793.12 ORX63215.1 - 0.14 10.7 2.7 0.21 10.1 2.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NTP_transf_2 PF01909.23 ORX63216.1 - 1.5e-07 31.6 0.0 4.1e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Fibrinogen_BP PF08017.11 ORX63216.1 - 0.041 12.3 4.4 0.061 11.7 4.4 1.1 1 0 0 1 1 1 0 Fibrinogen binding protein Polbeta PF18765.1 ORX63216.1 - 0.053 13.6 0.3 0.19 11.8 0.0 2.1 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase Borrelia_P83 PF05262.11 ORX63216.1 - 0.21 10.0 13.4 0.34 9.3 13.4 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein BAF1_ABF1 PF04684.13 ORX63216.1 - 0.54 9.2 12.8 0.83 8.6 12.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF3333 PF11812.8 ORX63216.1 - 2.2 8.5 7.5 4.3 7.5 7.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) PAT1 PF09770.9 ORX63216.1 - 6 5.0 20.0 11 4.1 20.0 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GREB1 PF15782.5 ORX63216.1 - 8.9 3.3 13.7 13 2.7 13.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Mlh1_C PF16413.5 ORX63217.1 - 2e-79 266.8 0.0 3e-79 266.2 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 ORX63217.1 - 1.2e-31 108.8 0.2 2.9e-31 107.6 0.2 1.7 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 ORX63217.1 - 2.3e-13 50.2 0.0 5.2e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ORX63217.1 - 1e-06 29.2 0.0 2.8e-06 27.8 0.0 1.8 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HV_small_capsid PF17086.5 ORX63217.1 - 0.14 12.5 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 Small capsid protein of Herpesviridae Pkinase PF00069.25 ORX63218.1 - 2.1e-53 181.4 0.0 2.6e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ORX63218.1 - 1.6e-21 76.8 0.1 5.1e-21 75.1 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ORX63218.1 - 0.00079 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ORX63218.1 - 0.0052 16.4 0.4 0.011 15.4 0.1 1.7 2 1 0 2 2 2 1 RIO1 family Choline_kinase PF01633.20 ORX63218.1 - 0.02 14.5 0.0 0.033 13.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase FMN_red PF03358.15 ORX63219.1 - 3.1e-13 49.7 0.0 4.9e-13 49.1 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ORX63219.1 - 3e-05 23.8 0.0 3.8e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold PIP5K PF01504.18 ORX63220.1 - 2.3e-38 132.0 1.3 2.8e-29 102.2 0.1 2.9 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase TMEM52 PF14979.6 ORX63222.1 - 1.6 8.6 4.9 1.7 8.6 4.9 1.2 1 0 0 1 1 1 0 Transmembrane 52 # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Hesseltinella_vesiculosa_NRRL3301-Hesve2/GCA_002104935.1_Hesve2_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Hesseltinella_vesiculosa_NRRL3301-Hesve2/GCA_002104935.1_Hesve2_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Hesseltinella_vesiculosa_NRRL3301-Hesve2/GCA_002104935.1_Hesve2_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Hesseltinella_vesiculosa_NRRL3301-Hesve2/GCA_002104935.1_Hesve2_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 21:44:30 2019 # [ok]