# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- DNA_pol_phi PF04931.13 KOS16594.1 - 6.2e-194 646.3 62.5 5.3e-168 560.5 0.8 3.1 2 1 1 3 3 3 3 DNA polymerase phi Rhodanese PF00581.20 KOS16595.1 - 6e-13 49.3 0.0 1e-12 48.5 0.0 1.3 1 0 0 1 1 1 1 Rhodanese-like domain CwfJ_C_1 PF04677.15 KOS16596.1 - 5e-22 78.0 0.0 2.5e-21 75.8 0.0 2.0 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 KOS16596.1 - 1.6e-16 60.9 0.1 3.1e-16 60.1 0.1 1.4 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 Ribosomal_60s PF00428.19 KOS16596.1 - 4.4 8.0 6.9 0.52 10.9 0.6 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein SelK_SelG PF10961.8 KOS16596.1 - 7.5 7.2 9.5 46 4.7 6.5 2.6 2 0 0 2 2 2 0 Selenoprotein SelK_SelG DRIM PF07539.12 KOS16597.1 - 9.6e-192 638.6 0.3 9.6e-192 638.6 0.3 3.0 3 0 0 3 3 3 1 Down-regulated in metastasis DUF3384 PF11864.8 KOS16597.1 - 0.0011 17.9 0.9 0.053 12.4 0.0 3.7 4 1 0 4 4 4 1 Domain of unknown function (DUF3384) HEAT PF02985.22 KOS16597.1 - 0.0047 17.1 17.1 20 5.8 0.1 9.8 10 1 1 11 11 11 1 HEAT repeat Adeno_terminal PF02459.15 KOS16597.1 - 0.015 13.7 0.2 0.031 12.7 0.2 1.4 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DNA_pol_phi PF04931.13 KOS16597.1 - 0.055 11.6 12.7 0.23 9.5 6.2 3.2 3 0 0 3 3 3 0 DNA polymerase phi TRAP_alpha PF03896.16 KOS16597.1 - 0.18 11.0 3.3 1.6 7.8 2.4 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF2828 PF11443.8 KOS16597.1 - 1.3 7.1 5.4 1.2 7.2 3.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) zf-DNL PF05180.12 KOS16598.1 - 1.9e-27 95.0 0.4 2.6e-27 94.5 0.4 1.2 1 0 0 1 1 1 1 DNL zinc finger zf-CSL PF05207.13 KOS16598.1 - 0.094 12.5 0.2 0.17 11.6 0.2 1.4 1 0 0 1 1 1 0 CSL zinc finger zf-RING_2 PF13639.6 KOS16598.1 - 0.36 11.2 3.0 0.56 10.6 3.0 1.3 1 0 0 1 1 1 0 Ring finger domain CAP PF00188.26 KOS16599.1 - 4.9e-12 46.8 0.9 5.8e-12 46.5 0.9 1.1 1 0 0 1 1 1 1 Cysteine-rich secretory protein family SNF5 PF04855.12 KOS16600.1 - 2.9e-91 305.5 0.0 3.8e-91 305.1 0.0 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 TAFH PF07531.14 KOS16600.1 - 0.13 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 NHR1 homology to TAF CUE PF02845.16 KOS16601.1 - 5.1e-06 26.1 0.0 9.2e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain TPR_14 PF13428.6 KOS16602.1 - 0.15 12.9 5.3 0.85 10.6 0.5 3.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS16602.1 - 0.25 12.0 9.5 0.14 12.8 5.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Ofd1_CTDD PF10637.9 KOS16603.1 - 1.2e-90 303.3 0.0 9.5e-87 290.6 0.0 2.4 2 0 0 2 2 2 2 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 KOS16603.1 - 4.1e-24 85.1 0.0 1.9e-23 82.9 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 KOS16603.1 - 1.7e-12 48.0 0.0 4e-12 46.9 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily BUD22 PF09073.10 KOS16603.1 - 0.1 11.9 28.6 0.5 9.7 12.9 2.2 2 0 0 2 2 2 0 BUD22 DUF1963 PF09234.10 KOS16603.1 - 3.7 7.9 7.7 0.11 12.9 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1963) RhlB PF12300.8 KOS16604.1 - 0.04 14.1 1.1 0.071 13.2 1.1 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB FAD_binding_4 PF01565.23 KOS16605.1 - 4.6e-20 71.8 2.4 8.6e-20 70.9 2.4 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS16605.1 - 0.00073 19.6 0.1 0.0022 18.0 0.1 1.9 2 0 0 2 2 2 1 Berberine and berberine like PCI PF01399.27 KOS16606.1 - 3.8e-19 69.1 0.2 1.1e-18 67.6 0.0 1.9 2 0 0 2 2 2 1 PCI domain TPR_7 PF13176.6 KOS16606.1 - 0.039 14.0 0.2 0.88 9.8 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOS16606.1 - 0.081 12.8 1.2 1.1 9.2 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS16606.1 - 0.082 13.1 0.2 0.082 13.1 0.2 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat RPM2 PF08579.11 KOS16606.1 - 0.15 12.5 3.1 2.9 8.3 0.2 3.2 2 1 1 3 3 3 0 Mitochondrial ribonuclease P subunit (RPM2) Peptidase_C65 PF10275.9 KOS16607.1 - 2e-63 214.1 0.0 2.5e-63 213.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain MotB_plug PF13677.6 KOS16607.1 - 0.017 14.7 2.4 0.037 13.6 2.4 1.6 1 1 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Gln-synt_C PF00120.24 KOS16608.1 - 2.6e-85 286.4 0.0 3.2e-85 286.2 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Methyltransf_23 PF13489.6 KOS16609.1 - 1.7e-13 50.7 0.0 3e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS16609.1 - 1.5e-08 35.2 0.0 3.6e-08 34.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS16609.1 - 8.5e-08 32.9 0.0 2.7e-07 31.2 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS16609.1 - 2.6e-06 28.0 0.0 5.1e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOS16609.1 - 2.3e-05 23.9 0.0 3.9e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_31 PF13847.6 KOS16609.1 - 0.00015 21.5 0.0 0.00071 19.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOS16609.1 - 0.0047 16.5 0.0 0.01 15.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 KOS16609.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_32 PF13679.6 KOS16609.1 - 0.11 12.4 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF2235 PF09994.9 KOS16610.1 - 7e-87 291.4 0.1 1.3e-86 290.6 0.1 1.4 1 1 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SelP_N PF04592.14 KOS16610.1 - 3.7 6.9 7.1 6 6.2 7.1 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Response_reg PF00072.24 KOS16611.1 - 5.1e-25 87.8 0.1 1.7e-24 86.1 0.1 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HATPase_c PF02518.26 KOS16611.1 - 7.7e-24 84.4 0.0 1.9e-23 83.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 KOS16611.1 - 1.3e-14 53.9 0.1 3.7e-14 52.5 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 KOS16611.1 - 2.1e-11 44.0 0.0 1.4e-09 38.2 0.0 3.3 4 0 0 4 4 4 1 PAS domain PAS PF00989.25 KOS16611.1 - 5.7e-08 32.8 0.0 1.3e-07 31.6 0.0 1.7 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 KOS16611.1 - 7.6e-08 32.6 0.0 8.9e-07 29.1 0.0 2.4 2 0 0 2 2 2 1 PAS fold Cas_Cas4 PF01930.17 KOS16612.1 - 0.089 12.9 0.0 0.13 12.3 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function DUF83 Radical_SAM PF04055.21 KOS16613.1 - 3.2e-13 50.4 0.2 6.7e-13 49.4 0.2 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 KOS16613.1 - 2.8e-06 27.5 1.5 7.5e-06 26.1 0.4 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 KOS16613.1 - 3e-06 27.6 2.0 6.5e-06 26.5 0.4 2.0 2 0 0 2 2 2 1 4Fe-4S single cluster domain ShK PF01549.24 KOS16613.1 - 0.2 12.2 3.9 0.18 12.4 2.1 1.9 2 0 0 2 2 2 0 ShK domain-like Serglycin PF04360.12 KOS16614.1 - 0.046 13.7 0.7 0.12 12.3 0.7 1.7 1 0 0 1 1 1 0 Serglycin SDA1 PF05285.12 KOS16615.1 - 0.13 11.7 2.5 0.19 11.1 2.5 1.2 1 0 0 1 1 1 0 SDA1 WRNPLPNID PF15017.6 KOS16615.1 - 0.58 11.1 7.1 0.53 11.2 2.6 2.5 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DNA_pol_phi PF04931.13 KOS16615.1 - 2.7 6.0 8.2 3.8 5.5 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mito_carr PF00153.27 KOS16616.1 - 3.3e-64 212.9 0.7 1e-20 73.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOS16616.1 - 0.005 16.0 0.3 0.046 12.9 0.0 2.5 3 0 0 3 3 3 1 Gammaproteobacterial serine protease TspO_MBR PF03073.15 KOS16617.1 - 5.4e-45 152.8 9.0 6.4e-45 152.5 9.0 1.1 1 0 0 1 1 1 1 TspO/MBR family AAA_22 PF13401.6 KOS16618.1 - 1.4e-14 54.5 0.0 3.2e-14 53.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS16618.1 - 1.5e-14 54.8 0.0 6.3e-14 52.7 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KOS16618.1 - 7e-09 36.2 0.0 2.1e-08 34.6 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 KOS16618.1 - 1.6e-07 31.8 0.1 2.3e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Cdc6_C PF09079.11 KOS16618.1 - 1.7e-06 27.9 0.1 6.7e-06 26.0 0.0 2.1 2 1 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_lid_10 PF17872.1 KOS16618.1 - 1.8e-06 28.0 0.1 4.5e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_30 PF13604.6 KOS16618.1 - 1.4e-05 24.9 0.0 3.1e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS16618.1 - 0.00027 20.9 0.0 0.00058 19.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 KOS16618.1 - 0.00049 19.4 0.0 0.00073 18.9 0.0 1.5 1 1 0 1 1 1 1 KAP family P-loop domain AAA_7 PF12775.7 KOS16618.1 - 0.00063 19.3 0.0 0.0016 18.0 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region Rad17 PF03215.15 KOS16618.1 - 0.0023 17.9 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain DUF815 PF05673.13 KOS16618.1 - 0.0031 16.7 0.0 0.01 15.0 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) DUF5618 PF18498.1 KOS16618.1 - 0.0031 17.7 0.0 0.0064 16.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5618) TniB PF05621.11 KOS16618.1 - 0.0044 16.5 0.0 0.011 15.1 0.0 1.7 1 1 0 1 1 1 1 Bacterial TniB protein RNA_helicase PF00910.22 KOS16618.1 - 0.0084 16.5 0.0 0.023 15.1 0.0 1.8 2 0 0 2 2 1 1 RNA helicase ATPase_2 PF01637.18 KOS16618.1 - 0.0091 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea Sigma54_activat PF00158.26 KOS16618.1 - 0.014 15.2 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 KOS16618.1 - 0.016 15.7 0.0 0.088 13.3 0.0 2.2 2 0 0 2 2 2 0 ABC transporter AAA_14 PF13173.6 KOS16618.1 - 0.027 14.5 0.0 0.091 12.8 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_32 PF13654.6 KOS16618.1 - 0.043 12.6 0.0 0.08 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOS16618.1 - 0.07 12.9 0.1 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 KOS16618.1 - 0.13 12.0 0.0 2.4 7.8 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 KOS16618.1 - 0.14 11.4 0.0 0.22 10.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 KOS16618.1 - 0.14 12.7 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain SHR3_chaperone PF08229.11 KOS16619.1 - 2.7e-73 245.0 0.0 3e-73 244.8 0.0 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF2157 PF09925.9 KOS16619.1 - 0.016 15.0 0.3 4.5 7.1 0.0 2.7 2 1 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF5453 PF17534.2 KOS16619.1 - 0.94 9.4 7.3 0.41 10.6 2.3 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5453) Mito_carr PF00153.27 KOS16620.1 - 3e-63 209.8 0.0 5.6e-21 74.3 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein IMS PF00817.20 KOS16621.1 - 2.7e-38 131.3 0.0 5.5e-38 130.3 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family REV1_C PF16727.5 KOS16621.1 - 3.6e-25 88.2 1.3 7.2e-25 87.2 1.3 1.5 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain IMS_C PF11799.8 KOS16621.1 - 6.9e-12 46.1 0.0 2e-11 44.6 0.0 1.8 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain UBM PF14377.6 KOS16621.1 - 2.8e-09 36.1 1.0 1.8e-05 24.0 0.2 4.5 5 0 0 5 5 5 2 Ubiquitin binding region BRCT_2 PF16589.5 KOS16621.1 - 2.1e-08 34.4 0.0 4.3e-08 33.5 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain mCpol PF18182.1 KOS16621.1 - 0.003 17.9 0.0 0.0069 16.7 0.0 1.5 1 0 0 1 1 1 1 minimal CRISPR polymerase domain BRCT PF00533.26 KOS16621.1 - 0.0035 17.7 0.0 0.0077 16.6 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain MgtE_N PF03448.17 KOS16621.1 - 0.0046 17.5 0.8 1.4 9.6 0.1 3.4 3 0 0 3 3 3 1 MgtE intracellular N domain IMS_HHH PF11798.8 KOS16621.1 - 0.023 15.0 0.0 0.2 12.0 0.0 2.7 2 0 0 2 2 2 0 IMS family HHH motif WSC PF01822.19 KOS16622.1 - 7.6e-18 64.5 6.4 1.1e-17 63.9 6.4 1.3 1 0 0 1 1 1 1 WSC domain IU_nuc_hydro PF01156.19 KOS16623.1 - 3.1e-56 191.2 0.0 3.7e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PAH PF02671.21 KOS16623.1 - 0.055 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Paired amphipathic helix repeat RED_N PF07808.13 KOS16624.1 - 3.4e-07 30.1 3.3 3.4e-07 30.1 3.3 2.9 3 1 0 3 3 3 2 RED-like protein N-terminal region FA_hydroxylase PF04116.13 KOS16625.1 - 4.5e-24 85.3 12.1 4.5e-24 85.3 12.1 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Mg_trans_NIPA PF05653.14 KOS16626.1 - 9.3e-59 198.9 10.3 1.8e-56 191.5 7.5 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA EamA PF00892.20 KOS16626.1 - 0.0036 17.5 23.2 0.0083 16.3 0.7 3.3 3 1 0 3 3 3 2 EamA-like transporter family YfhO PF09586.10 KOS16626.1 - 0.011 14.1 2.3 0.015 13.5 2.3 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Phage_holin_2_3 PF16080.5 KOS16626.1 - 0.055 13.2 0.5 0.3 10.9 0.5 2.2 1 0 0 1 1 1 0 Bacteriophage holin family HP1 DUF4345 PF14248.6 KOS16626.1 - 0.3 11.0 10.6 13 5.7 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4345) DUF1461 PF07314.11 KOS16626.1 - 2.3 8.1 4.9 1.2 9.0 2.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) LysE PF01810.18 KOS16626.1 - 9.4 5.6 14.7 0.18 11.2 2.2 3.2 3 1 1 4 4 4 0 LysE type translocator ADH_zinc_N PF00107.26 KOS16627.1 - 5.3e-22 78.2 0.0 7.6e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 KOS16627.1 - 8.3e-17 61.0 0.0 1.8e-16 60.0 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N_2 PF13602.6 KOS16627.1 - 1.1e-08 36.2 0.0 3e-08 34.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PPR_2 PF13041.6 KOS16628.1 - 3.7e-16 59.0 0.0 1.9e-07 31.2 0.0 6.2 5 2 2 7 7 7 5 PPR repeat family PPR_3 PF13812.6 KOS16628.1 - 7.7e-14 51.5 0.0 2.1e-06 27.7 0.0 4.4 5 0 0 5 5 5 3 Pentatricopeptide repeat domain PPR_long PF17177.4 KOS16628.1 - 2.6e-08 33.5 0.0 0.00074 18.9 0.0 3.7 2 1 2 4 4 4 3 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOS16628.1 - 3.2e-06 26.7 0.0 0.023 14.4 0.0 4.5 5 0 0 5 5 5 2 PPR repeat PPR PF01535.20 KOS16628.1 - 1.1e-05 25.3 0.0 2.7 8.4 0.0 4.7 5 0 0 5 5 5 2 PPR repeat Arg_decarb_HB PF17810.1 KOS16628.1 - 0.069 13.4 0.8 9.8 6.5 0.0 4.1 5 1 1 6 6 6 0 Arginine decarboxylase helical bundle domain Mis12 PF05859.12 KOS16629.1 - 1.4e-43 148.1 0.0 2.5e-43 147.4 0.0 1.4 1 0 0 1 1 1 1 Mis12 protein EMP24_GP25L PF01105.24 KOS16630.1 - 1.4e-45 155.5 0.3 1.6e-45 155.3 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3405 PF11885.8 KOS16631.1 - 5.3e-226 751.2 0.1 6.2e-226 751.0 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) Corona_nucleoca PF00937.18 KOS16631.1 - 0.022 13.8 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein RRM_1 PF00076.22 KOS16633.1 - 2.3e-14 53.0 0.0 1.6e-06 27.8 0.0 3.2 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS16633.1 - 0.034 14.3 0.0 0.072 13.2 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Serglycin PF04360.12 KOS16633.1 - 0.13 12.2 1.2 0.28 11.1 1.2 1.5 1 0 0 1 1 1 0 Serglycin GTP-bdg_M PF16360.5 KOS16633.1 - 0.41 11.3 4.7 2.3 8.9 4.7 2.1 1 1 0 1 1 1 0 GTP-binding GTPase Middle Region Peptidase_M49 PF03571.15 KOS16634.1 - 3.6e-245 814.5 0.0 4.3e-245 814.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M49 2C_adapt PF08793.10 KOS16634.1 - 0.026 14.7 0.5 0.067 13.4 0.5 1.7 1 0 0 1 1 1 0 2-cysteine adaptor domain Ribosomal_L6e PF01159.19 KOS16635.1 - 1.4e-38 131.8 0.6 1.4e-38 131.8 0.6 1.4 2 0 0 2 2 2 1 Ribosomal protein L6e AAA_2 PF07724.14 KOS16636.1 - 7.6e-46 156.3 0.0 2e-44 151.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOS16636.1 - 1.3e-35 121.4 8.7 1.9e-35 120.9 2.4 2.6 2 0 0 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 KOS16636.1 - 3.1e-24 84.8 0.1 1.4e-23 82.8 0.1 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 KOS16636.1 - 8.2e-20 71.6 2.1 7.6e-11 42.6 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOS16636.1 - 1.4e-13 51.1 0.1 4.4e-09 36.5 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOS16636.1 - 4.3e-11 43.5 3.7 0.0001 22.7 0.1 4.1 2 2 2 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 KOS16636.1 - 3.9e-08 33.7 1.6 0.015 15.5 0.0 3.5 3 1 0 3 3 3 2 AAA domain Sigma54_activat PF00158.26 KOS16636.1 - 4.3e-08 33.1 0.2 0.00016 21.5 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain ATPase_2 PF01637.18 KOS16636.1 - 7.3e-07 29.3 2.5 0.32 10.9 0.1 4.1 3 2 2 5 5 4 2 ATPase domain predominantly from Archaea AAA_14 PF13173.6 KOS16636.1 - 3.4e-06 27.1 0.0 0.06 13.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain TniB PF05621.11 KOS16636.1 - 3.8e-06 26.4 0.0 0.0036 16.7 0.1 3.5 3 1 0 3 3 2 1 Bacterial TniB protein NACHT PF05729.12 KOS16636.1 - 1.8e-05 24.7 0.0 0.19 11.6 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_7 PF12775.7 KOS16636.1 - 2.3e-05 24.0 0.0 0.18 11.3 0.0 2.5 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_18 PF13238.6 KOS16636.1 - 4.8e-05 23.9 1.6 0.11 13.0 0.0 3.4 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 KOS16636.1 - 5.1e-05 23.1 0.1 0.15 11.8 0.0 2.7 2 1 0 2 2 2 2 IstB-like ATP binding protein AAA_24 PF13479.6 KOS16636.1 - 0.00026 20.8 0.0 0.29 10.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOS16636.1 - 0.00045 20.5 0.2 0.83 9.9 0.0 3.5 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 KOS16636.1 - 0.00068 20.0 0.0 0.34 11.3 0.0 2.9 2 1 0 2 2 2 1 RNA helicase TsaE PF02367.17 KOS16636.1 - 0.001 19.1 0.0 2.4 8.2 0.0 2.8 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 KOS16636.1 - 0.0012 19.4 4.9 1 9.9 2.2 3.3 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 KOS16636.1 - 0.0012 19.4 0.8 0.94 10.0 0.0 3.3 3 0 0 3 3 3 1 ABC transporter Roc PF08477.13 KOS16636.1 - 0.0014 18.9 0.0 1.2 9.4 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 KOS16636.1 - 0.0015 18.2 0.0 0.16 11.6 0.0 2.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 KOS16636.1 - 0.0017 18.1 0.1 0.14 11.8 0.2 3.0 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOS16636.1 - 0.005 16.8 1.0 2.1 8.2 0.0 2.9 3 0 0 3 3 2 1 RsgA GTPase OEP PF02321.18 KOS16636.1 - 0.0051 16.6 2.9 0.011 15.6 2.9 1.4 1 0 0 1 1 1 1 Outer membrane efflux protein ResIII PF04851.15 KOS16636.1 - 0.0055 16.7 0.1 3.2 7.7 0.0 3.2 2 1 0 3 3 3 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 KOS16636.1 - 0.0063 15.9 0.1 2.1 7.7 0.0 3.1 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 KOS16636.1 - 0.007 15.6 0.5 0.42 9.7 0.2 3.2 3 1 0 3 3 2 1 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 KOS16636.1 - 0.012 14.9 0.0 0.88 8.8 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 KOS16636.1 - 0.013 15.8 1.5 0.34 11.3 0.1 3.2 2 2 1 3 3 3 0 AAA domain NTPase_1 PF03266.15 KOS16636.1 - 0.019 14.9 0.0 0.43 10.5 0.0 2.6 2 0 0 2 2 2 0 NTPase PduV-EutP PF10662.9 KOS16636.1 - 0.027 14.2 0.0 0.85 9.4 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_33 PF13671.6 KOS16636.1 - 0.033 14.4 0.0 15 5.7 0.0 2.7 2 0 0 2 2 2 0 AAA domain CENP-F_leu_zip PF10473.9 KOS16636.1 - 0.038 14.0 11.5 0.15 12.1 11.5 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PIF1 PF05970.14 KOS16636.1 - 0.039 13.1 0.0 1.9 7.6 0.0 2.5 3 0 0 3 3 2 0 PIF1-like helicase AAA_25 PF13481.6 KOS16636.1 - 0.043 13.4 0.1 0.78 9.3 0.0 2.7 2 0 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 KOS16636.1 - 0.056 12.4 0.0 1.5 7.7 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain PhoH PF02562.16 KOS16636.1 - 0.071 12.6 0.0 2.2 7.7 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein ATP_bind_1 PF03029.17 KOS16636.1 - 0.083 12.7 0.0 0.81 9.4 0.0 2.4 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Zw10 PF06248.13 KOS16636.1 - 0.11 11.1 1.6 0.17 10.4 1.6 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 AAA_6 PF12774.7 KOS16636.1 - 0.11 11.5 0.0 2 7.3 0.0 2.2 2 0 0 2 2 2 0 Hydrolytic ATP binding site of dynein motor region AAA_29 PF13555.6 KOS16636.1 - 0.13 12.0 0.1 6.4 6.6 0.0 2.7 3 0 0 3 3 2 0 P-loop containing region of AAA domain DUF1640 PF07798.11 KOS16636.1 - 0.18 11.9 5.7 0.34 10.9 5.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Cob_adeno_trans PF01923.18 KOS16636.1 - 0.44 10.7 3.4 1.3 9.1 3.4 1.7 1 0 0 1 1 1 0 Cobalamin adenosyltransferase PKcGMP_CC PF16808.5 KOS16636.1 - 1.4 8.8 11.5 6.4 6.7 2.6 2.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF87 PF01935.17 KOS16636.1 - 2.2 8.3 5.9 16 5.5 0.0 3.2 3 0 0 3 3 3 0 Helicase HerA, central domain FAM76 PF16046.5 KOS16636.1 - 4 6.7 4.7 6.5 6.0 4.7 1.2 1 0 0 1 1 1 0 FAM76 protein GrpE PF01025.19 KOS16636.1 - 4.1 7.1 9.1 4.6 6.9 7.5 2.0 2 0 0 2 2 1 0 GrpE AAA_21 PF13304.6 KOS16636.1 - 5.1 6.8 5.7 3.1 7.5 0.0 3.2 3 2 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system DivIC PF04977.15 KOS16636.1 - 7.2 6.5 8.9 10 5.9 5.6 2.5 1 1 1 2 2 2 0 Septum formation initiator Arf PF00025.21 KOS16637.1 - 3e-79 264.5 0.2 3.6e-79 264.3 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 KOS16637.1 - 1.8e-14 53.6 0.0 2.3e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOS16637.1 - 2.7e-14 53.4 0.0 3.9e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 KOS16637.1 - 3e-13 49.7 1.3 2.4e-09 36.8 0.3 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KOS16637.1 - 3.1e-13 49.6 0.0 3.5e-13 49.5 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOS16637.1 - 2.1e-10 40.3 0.0 2.6e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS16637.1 - 5.4e-06 26.5 0.0 8.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KOS16637.1 - 0.0071 15.7 0.4 0.028 13.7 0.1 1.8 2 0 0 2 2 2 1 6-phosphofructo-2-kinase 2-oxoacid_dh PF00198.23 KOS16638.1 - 5.1e-74 248.6 0.0 6.6e-74 248.3 0.0 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOS16638.1 - 1e-16 60.5 0.1 2.2e-16 59.4 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOS16638.1 - 6.4e-13 48.8 0.2 6.4e-13 48.8 0.2 2.1 2 0 0 2 2 2 1 e3 binding domain SKI PF01202.22 KOS16639.1 - 1.4e-12 48.0 0.0 2.1e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 KOS16639.1 - 2e-11 44.3 0.1 8.7e-11 42.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS16639.1 - 1.3e-09 38.7 0.0 3.8e-09 37.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOS16639.1 - 1.7e-07 31.7 0.0 3.7e-07 30.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS16639.1 - 1.4e-06 28.8 0.0 2e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Cytidylate_kin PF02224.18 KOS16639.1 - 2e-06 27.7 0.3 4.7e-06 26.5 0.0 1.8 2 0 0 2 2 1 1 Cytidylate kinase AAA PF00004.29 KOS16639.1 - 7.1e-06 26.5 0.2 2e-05 25.1 0.0 2.0 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOS16639.1 - 7.3e-06 26.0 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 KOS16639.1 - 0.00014 22.1 0.0 0.00022 21.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 KOS16639.1 - 0.00037 20.4 0.0 0.00056 19.8 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase RuvB_N PF05496.12 KOS16639.1 - 0.00037 20.3 0.1 0.00087 19.1 0.1 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOS16639.1 - 0.00045 20.5 0.1 0.0007 19.9 0.1 1.5 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS16639.1 - 0.00056 19.9 0.0 0.0012 18.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) dNK PF01712.19 KOS16639.1 - 0.0006 19.7 0.0 0.2 11.5 0.0 2.3 2 0 0 2 2 2 1 Deoxynucleoside kinase Mg_chelatase PF01078.21 KOS16639.1 - 0.0016 17.9 2.5 0.0022 17.4 0.5 2.1 2 1 1 3 3 3 1 Magnesium chelatase, subunit ChlI Cytidylate_kin2 PF13189.6 KOS16639.1 - 0.0016 18.6 0.0 0.0098 16.0 0.0 2.3 1 1 0 1 1 1 1 Cytidylate kinase-like family PRK PF00485.18 KOS16639.1 - 0.002 17.9 0.4 0.0039 17.0 0.0 1.7 2 0 0 2 2 1 1 Phosphoribulokinase / Uridine kinase family NACHT PF05729.12 KOS16639.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 KOS16639.1 - 0.0031 17.3 1.0 0.0055 16.5 0.2 1.8 1 1 1 2 2 2 1 AAA domain T2SSE PF00437.20 KOS16639.1 - 0.0032 16.6 0.3 0.0052 15.9 0.3 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 KOS16639.1 - 0.0046 17.0 0.0 0.011 15.7 0.0 1.9 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOS16639.1 - 0.0055 17.1 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase Alg14 PF08660.11 KOS16639.1 - 0.0066 16.4 0.2 0.016 15.1 0.1 1.7 2 1 0 2 2 2 1 Oligosaccharide biosynthesis protein Alg14 like AAA_19 PF13245.6 KOS16639.1 - 0.007 16.7 0.3 0.007 16.7 0.3 2.2 2 1 1 3 3 3 1 AAA domain NTPase_1 PF03266.15 KOS16639.1 - 0.0078 16.1 0.0 0.022 14.7 0.0 1.7 1 1 1 2 2 2 1 NTPase TsaE PF02367.17 KOS16639.1 - 0.013 15.5 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 KOS16639.1 - 0.015 14.7 0.1 0.029 13.8 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 KOS16639.1 - 0.018 15.0 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 KOS16639.1 - 0.019 14.8 0.0 0.028 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 KOS16639.1 - 0.019 14.6 0.0 0.047 13.4 0.0 1.7 2 0 0 2 2 1 0 Dephospho-CoA kinase Thymidylate_kin PF02223.17 KOS16639.1 - 0.019 14.6 0.0 4.9 6.8 0.0 2.3 2 0 0 2 2 2 0 Thymidylate kinase IstB_IS21 PF01695.17 KOS16639.1 - 0.021 14.6 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 KOS16639.1 - 0.026 14.0 0.1 0.043 13.3 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region CobU PF02283.16 KOS16639.1 - 0.034 13.7 0.0 0.075 12.6 0.0 1.7 1 1 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase ABC_tran PF00005.27 KOS16639.1 - 0.034 14.7 0.0 0.048 14.2 0.0 1.4 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 KOS16639.1 - 0.037 13.9 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase DUF2075 PF09848.9 KOS16639.1 - 0.039 13.2 0.0 0.059 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Thermopsin PF05317.11 KOS16639.1 - 0.039 13.4 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Thermopsin AAA_25 PF13481.6 KOS16639.1 - 0.042 13.4 0.9 0.089 12.4 0.3 1.8 1 1 1 2 2 2 0 AAA domain Herpes_Helicase PF02689.14 KOS16639.1 - 0.048 11.6 0.1 0.061 11.2 0.1 1.1 1 0 0 1 1 1 0 Helicase ADK PF00406.22 KOS16639.1 - 0.058 13.5 0.1 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase Zeta_toxin PF06414.12 KOS16639.1 - 0.061 12.6 0.0 0.12 11.7 0.0 1.5 2 0 0 2 2 1 0 Zeta toxin Sigma54_activat PF00158.26 KOS16639.1 - 0.063 13.0 0.0 0.18 11.5 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain ATPase PF06745.13 KOS16639.1 - 0.076 12.3 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 KaiC NB-ARC PF00931.22 KOS16639.1 - 0.077 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_PrkA PF08298.11 KOS16639.1 - 0.12 11.3 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 PrkA AAA domain AAA_23 PF13476.6 KOS16639.1 - 0.18 12.3 0.0 0.3 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_pol_Rpc4 PF05132.14 KOS16640.1 - 0.013 15.9 1.6 0.022 15.2 1.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4719 PF15843.5 KOS16640.1 - 0.052 13.7 0.1 0.079 13.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) RRN3 PF05327.11 KOS16640.1 - 0.51 8.8 2.4 0.64 8.5 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 WD40 PF00400.32 KOS16641.1 - 1.3e-53 177.7 13.0 2.7e-08 34.3 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 KOS16641.1 - 3.1e-18 65.8 10.7 5.2e-18 65.1 10.7 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 KOS16641.1 - 6.3e-12 45.6 0.0 0.051 13.9 0.0 5.3 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 KOS16641.1 - 1.4e-06 27.9 0.0 0.44 9.8 0.0 4.6 4 1 1 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 KOS16641.1 - 0.00021 20.4 0.4 9 5.2 0.0 4.8 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SHE3 PF17078.5 KOS16641.1 - 0.015 15.0 1.7 0.023 14.4 1.7 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Filament PF00038.21 KOS16641.1 - 0.023 14.3 2.3 0.033 13.8 2.3 1.1 1 0 0 1 1 1 0 Intermediate filament protein PD40 PF07676.12 KOS16641.1 - 0.055 13.4 0.0 22 5.2 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 KOS16641.1 - 0.07 11.8 0.6 0.79 8.3 0.1 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Fib_alpha PF08702.10 KOS16641.1 - 0.087 13.0 0.3 0.14 12.3 0.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family zf-rbx1 PF12678.7 KOS16642.1 - 9.6e-25 86.6 12.6 1.3e-24 86.2 12.6 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOS16642.1 - 5.6e-17 61.6 9.8 7.2e-17 61.2 9.8 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 KOS16642.1 - 2.2e-06 27.9 13.8 8.5e-05 22.8 13.8 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOS16642.1 - 3.7e-05 23.5 2.7 3.7e-05 23.5 2.7 2.3 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS16642.1 - 0.0018 18.1 11.5 0.034 14.0 11.5 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS16642.1 - 0.25 11.1 15.8 24 4.8 15.8 2.5 1 1 0 1 1 1 0 RING-like zinc finger zf-RING_UBOX PF13445.6 KOS16642.1 - 0.32 11.1 7.1 1.2 9.2 7.1 2.0 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOS16642.1 - 0.36 10.7 11.0 1.2 9.0 4.8 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 KOS16642.1 - 0.86 9.8 9.2 5.1 7.4 9.4 2.0 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 KOS16642.1 - 1.5 8.5 14.9 2.4e+02 1.5 14.9 2.3 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type CorA PF01544.18 KOS16643.1 - 1.8e-37 129.2 0.0 2.9e-37 128.6 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ALS2CR11 PF15729.5 KOS16643.1 - 0.19 10.8 0.3 0.39 9.8 0.3 1.4 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 zf-Tim10_DDP PF02953.15 KOS16644.1 - 2e-21 75.4 3.1 2.8e-21 74.9 3.1 1.2 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Ribosomal_L23eN PF03939.13 KOS16645.1 - 1.6e-23 82.6 5.5 1.6e-23 82.6 5.5 2.7 2 1 1 3 3 3 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 KOS16645.1 - 4.5e-16 59.0 0.6 9.1e-16 58.0 0.6 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 Bmt2 PF11968.8 KOS16646.1 - 2.1e-82 276.2 0.0 2.8e-82 275.8 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 KOS16646.1 - 0.066 13.0 0.0 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain HAD_2 PF13419.6 KOS16647.1 - 0.06 13.4 0.0 0.073 13.2 0.0 1.1 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pkinase PF00069.25 KOS16648.1 - 3.7e-57 193.7 0.0 5e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS16648.1 - 1.1e-36 126.5 0.0 1.5e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS16648.1 - 5.3e-12 45.7 0.0 8.1e-10 38.5 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 KOS16648.1 - 0.0034 16.8 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Aa_trans PF01490.18 KOS16649.1 - 2.3e-52 178.1 19.7 3.2e-52 177.6 19.7 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 KOS16649.1 - 0.00012 21.3 8.1 0.00012 21.3 8.1 1.9 2 0 0 2 2 2 1 Tryptophan/tyrosine permease family LRR_6 PF13516.6 KOS16650.1 - 3.3e-10 39.2 4.2 0.0011 18.8 0.0 6.3 7 0 0 7 7 7 2 Leucine Rich repeat LRR_4 PF12799.7 KOS16650.1 - 2.2e-07 31.1 1.8 0.023 15.1 0.0 5.1 6 0 0 6 6 6 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS16650.1 - 3.4e-05 23.5 2.0 0.23 11.3 0.0 4.8 4 1 0 4 4 4 1 Leucine rich repeat LRR_1 PF00560.33 KOS16650.1 - 0.0078 16.6 0.4 14 6.7 0.0 4.8 5 0 0 5 5 5 1 Leucine Rich Repeat CobT PF06213.12 KOS16650.1 - 3 7.1 17.5 6 6.2 17.5 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Cytochrom_C1 PF02167.15 KOS16651.1 - 5.7e-91 304.1 0.0 7e-91 303.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 KOS16651.1 - 0.0066 16.7 0.0 0.014 15.7 0.0 1.7 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III PCI PF01399.27 KOS16653.1 - 2.3e-12 47.4 0.0 5.1e-12 46.2 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_12 PF13424.6 KOS16653.1 - 0.00015 22.0 2.6 0.12 12.7 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS16653.1 - 0.00049 20.1 0.2 0.4 11.0 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS16653.1 - 0.0014 18.6 0.3 1.6 9.0 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat RPN7 PF10602.9 KOS16653.1 - 0.027 14.2 0.2 0.027 14.2 0.2 1.9 2 1 1 3 3 3 0 26S proteasome subunit RPN7 TPR_1 PF00515.28 KOS16653.1 - 0.044 13.6 0.1 0.42 10.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS16653.1 - 2.9 8.6 7.3 21 5.9 0.1 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat Ras PF00071.22 KOS16654.1 - 1.6e-53 180.6 0.0 1.9e-53 180.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS16654.1 - 1.7e-21 76.7 0.0 2.6e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS16654.1 - 3.1e-08 33.3 0.0 6.9e-08 32.1 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOS16654.1 - 0.0025 17.2 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KOS16654.1 - 0.0057 15.9 0.0 0.014 14.6 0.0 1.4 1 1 0 1 1 1 1 G-protein alpha subunit SRPRB PF09439.10 KOS16654.1 - 0.0066 15.9 0.0 0.0086 15.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOS16654.1 - 0.029 14.4 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 KOS16654.1 - 0.12 12.9 0.0 0.32 11.5 0.0 1.4 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 KOS16654.1 - 0.13 12.0 0.0 3.2 7.5 0.0 2.6 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 KOS16654.1 - 0.19 12.1 0.7 0.43 10.9 0.7 1.9 1 1 0 1 1 1 0 AAA ATPase domain Ribosomal_L37 PF08561.10 KOS16656.1 - 3.2e-40 137.4 3.5 3.8e-40 137.1 3.5 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L37 FXR_C1 PF16096.5 KOS16656.1 - 0.033 14.4 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 PNKP-ligase_C PF16536.5 KOS16656.1 - 0.28 11.4 2.0 0.74 10.1 0.8 2.0 2 0 0 2 2 2 0 PNKP adenylyltransferase domain, C-terminal region NDUFB10 PF10249.9 KOS16657.1 - 0.043 14.3 0.0 0.057 13.9 0.0 1.3 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 RRM_1 PF00076.22 KOS16658.1 - 4.7e-40 135.3 0.1 8.5e-21 73.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS16658.1 - 0.00074 19.6 0.0 1.6 8.9 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif SET_assoc PF11767.8 KOS16658.1 - 0.075 12.7 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 Histone lysine methyltransferase SET associated TMF_DNA_bd PF12329.8 KOS16659.1 - 0.023 14.7 1.9 0.023 14.7 1.9 9.7 5 4 2 9 9 9 0 TATA element modulatory factor 1 DNA binding APS_kinase PF01583.20 KOS16659.1 - 0.29 11.0 2.9 7.5 6.4 0.1 2.5 2 0 0 2 2 2 0 Adenylylsulphate kinase SAM_KSR1 PF13543.6 KOS16659.1 - 3 8.0 14.0 4 7.6 0.3 4.2 4 0 0 4 4 4 0 SAM like domain present in kinase suppressor RAS 1 ATG16 PF08614.11 KOS16659.1 - 3.4 7.9 82.0 0.16 12.2 6.6 6.0 3 1 1 5 5 5 0 Autophagy protein 16 (ATG16) CRR7 PF12095.8 KOS16659.1 - 5.9 7.4 18.2 5.9 7.4 1.4 5.1 4 1 1 5 5 5 0 Protein CHLORORESPIRATORY REDUCTION 7 Noelin-1 PF12308.8 KOS16659.1 - 8.8 6.4 21.1 5.2 7.1 0.1 6.1 4 2 1 6 6 6 0 Neurogenesis glycoprotein Med16 PF11635.8 KOS16661.1 - 2.3e-70 237.5 0.0 3e-36 124.7 0.0 2.0 2 0 0 2 2 2 2 Mediator complex subunit 16 RsgA_GTPase PF03193.16 KOS16662.1 - 0.056 13.3 0.0 0.07 13.0 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase GTP_EFTU PF00009.27 KOS16663.1 - 2.9e-58 196.6 0.0 5.1e-58 195.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 KOS16663.1 - 7.2e-17 61.2 0.0 2.3e-16 59.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOS16663.1 - 3.6e-11 43.3 0.0 1e-10 41.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOS16663.1 - 4.4e-07 29.9 0.0 1.9e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 Elongation Factor G, domain II EFG_IV PF03764.18 KOS16663.1 - 0.00025 20.8 0.0 0.0035 17.1 0.0 2.6 2 1 1 3 3 3 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 KOS16663.1 - 0.07 13.2 0.0 0.2 11.7 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOS16663.1 - 0.15 12.3 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fungal_trans PF04082.18 KOS16664.1 - 4.1e-19 68.7 0.5 4.1e-19 68.7 0.5 1.9 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS16664.1 - 0.00053 20.1 5.8 0.0009 19.3 5.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PTPRCAP PF15713.5 KOS16664.1 - 0.0014 18.9 3.4 0.0025 18.1 3.4 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated TFIIA PF03153.13 KOS16664.1 - 0.0038 17.3 20.6 0.0066 16.5 20.6 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 KOS16664.1 - 0.019 15.2 1.3 0.038 14.2 1.3 1.5 1 0 0 1 1 1 0 DDHD domain DUF3619 PF12279.8 KOS16664.1 - 0.023 15.0 1.8 0.023 15.0 1.8 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF3619) EKR PF10371.9 KOS16664.1 - 0.042 13.6 0.0 0.24 11.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function Spt20 PF12090.8 KOS16664.1 - 0.07 12.7 27.6 0.11 12.1 27.6 1.2 1 0 0 1 1 1 0 Spt20 family DUF4770 PF15994.5 KOS16664.1 - 0.11 12.8 6.8 0.18 12.0 6.1 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4770) PAT1 PF09770.9 KOS16664.1 - 0.13 10.5 12.4 0.18 10.1 12.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EIF4E-T PF10477.9 KOS16664.1 - 0.14 11.0 11.4 0.2 10.4 11.4 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Suf PF05843.14 KOS16664.1 - 0.38 10.7 9.4 0.69 9.9 9.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 KOS16664.1 - 0.41 10.7 2.4 0.87 9.6 2.4 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tim54 PF11711.8 KOS16664.1 - 0.49 9.1 8.0 0.8 8.4 8.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 UPF0560 PF10577.9 KOS16664.1 - 0.5 8.8 12.0 0.82 8.1 12.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TERB2 PF15101.6 KOS16664.1 - 0.59 10.2 10.9 2.3 8.2 10.4 1.9 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Ndc1_Nup PF09531.10 KOS16664.1 - 0.72 8.5 6.9 1.2 7.7 6.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 KOS16664.1 - 0.99 10.0 18.4 0.74 10.5 15.4 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4175 PF13779.6 KOS16664.1 - 1.8 6.4 25.6 3 5.7 25.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TRM13 PF05206.14 KOS16664.1 - 2.8 7.4 7.4 4.8 6.6 7.4 1.3 1 0 0 1 1 1 0 Methyltransferase TRM13 DUF3464 PF11947.8 KOS16664.1 - 2.8 7.7 5.0 5 6.9 5.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TMEM51 PF15345.6 KOS16664.1 - 5.2 6.8 10.7 11 5.8 10.7 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF2722 PF10846.8 KOS16664.1 - 8.2 5.2 25.5 0.43 9.5 20.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) eIF-3_zeta PF05091.12 KOS16664.1 - 9.1 5.1 11.5 14 4.5 11.5 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Presenilin PF01080.17 KOS16664.1 - 9.6 4.9 10.3 15 4.2 10.3 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 KOS16664.1 - 9.7 7.2 12.1 22 6.1 12.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Fungal_trans PF04082.18 KOS16665.1 - 7.1e-13 48.2 0.0 1.2e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS16665.1 - 1.5e-06 28.2 10.6 2.8e-06 27.4 10.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIB PF00382.19 KOS16666.1 - 4.6e-34 116.3 0.8 2.5e-20 72.3 0.1 2.5 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 KOS16666.1 - 8.5e-11 41.2 3.2 1.5e-10 40.4 3.2 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 KOS16666.1 - 0.00012 22.1 0.1 0.13 12.3 0.0 2.9 2 1 1 3 3 3 2 Cyclin, C-terminal domain RB_B PF01857.20 KOS16666.1 - 0.00044 20.3 0.1 0.00077 19.5 0.1 1.5 1 0 0 1 1 1 1 Retinoblastoma-associated protein B domain Cyclin_N PF00134.23 KOS16666.1 - 0.0076 16.0 0.8 0.048 13.4 0.2 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Sigma70_r4_2 PF08281.12 KOS16666.1 - 0.041 13.6 0.0 0.14 11.8 0.0 1.9 2 0 0 2 2 2 0 Sigma-70, region 4 McrBC PF10117.9 KOS16666.1 - 0.072 12.2 0.8 1.3 8.1 0.2 2.1 1 1 1 2 2 2 0 McrBC 5-methylcytosine restriction system component HTH_Tnp_ISL3 PF13542.6 KOS16666.1 - 0.12 11.8 0.0 1.6 8.2 0.0 2.5 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 TFIIB_C_1 PF18542.1 KOS16666.1 - 0.13 12.3 0.5 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Transcription factor IIB C-terminal module 1 FA_hydroxylase PF04116.13 KOS16667.1 - 1.3e-23 83.8 14.4 1.3e-23 83.8 14.4 2.3 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Bac_export_2 PF01312.19 KOS16667.1 - 0.086 12.0 0.3 0.65 9.1 0.0 2.1 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family PhoLip_ATPase_C PF16212.5 KOS16668.1 - 1.6e-65 221.3 11.5 3.2e-65 220.4 11.5 1.5 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOS16668.1 - 7.6e-24 83.2 1.1 2.5e-22 78.3 0.0 2.9 3 0 0 3 3 3 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KOS16668.1 - 2.5e-12 47.6 0.1 7.7e-06 26.3 0.0 3.5 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS16668.1 - 8.5e-11 41.8 0.0 8.1e-10 38.7 0.0 2.2 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 KOS16668.1 - 1.3e-07 31.3 0.0 3.2e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOS16668.1 - 0.038 13.7 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SRP72 PF08492.12 KOS16668.1 - 3.3 8.2 16.7 0.14 12.6 5.0 2.7 2 0 0 2 2 2 0 SRP72 RNA-binding domain Neisseria_TspB PF05616.13 KOS16668.1 - 4.3 5.7 7.2 6.9 5.0 7.2 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF2015 PF09435.10 KOS16669.1 - 1.1e-43 147.7 0.0 1.2e-43 147.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) CoA_transf_3 PF02515.17 KOS16670.1 - 1.7e-127 425.6 0.0 1.9e-127 425.4 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III ExbD PF02472.16 KOS16670.1 - 0.025 14.7 0.1 0.041 14.0 0.1 1.3 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR Ribosomal_L28e PF01778.17 KOS16671.1 - 8.5e-35 120.0 0.2 1.2e-34 119.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal L28e protein family Peptidase_M76 PF09768.9 KOS16671.1 - 0.12 12.2 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Peptidase M76 family Glycos_transf_3 PF00591.21 KOS16672.1 - 1.7e-59 201.5 0.0 2.9e-59 200.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 KOS16672.1 - 7.3e-14 51.4 0.1 3.6e-13 49.1 0.1 2.0 2 0 0 2 2 2 1 Glycosyl transferase family, helical bundle domain Ldh_1_C PF02866.18 KOS16673.1 - 4.3e-48 163.4 0.0 6.5e-48 162.8 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOS16673.1 - 1e-43 148.8 0.1 1.4e-43 148.4 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KOS16673.1 - 0.0015 17.6 0.0 0.0021 17.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOS16673.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Semialdhyde_dh PF01118.24 KOS16673.1 - 0.095 13.1 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Asn_synthase PF00733.21 KOS16674.1 - 8.7e-17 61.8 1.1 4.1e-10 39.8 0.6 3.2 2 1 0 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 KOS16674.1 - 3.1e-08 33.6 0.0 1.8e-07 31.1 0.0 2.1 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOS16674.1 - 0.00018 21.7 0.0 0.00048 20.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain PCNP PF15473.6 KOS16675.1 - 0.24 12.1 8.2 0.39 11.5 0.5 2.4 2 0 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family DUF2423 PF10338.9 KOS16676.1 - 3.1e-19 68.9 5.8 3.1e-19 68.9 5.8 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) AICARFT_IMPCHas PF01808.18 KOS16677.1 - 1.8e-91 306.7 0.0 2.4e-91 306.3 0.0 1.1 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 KOS16677.1 - 4.8e-23 81.2 0.0 8.4e-23 80.4 0.0 1.4 1 0 0 1 1 1 1 MGS-like domain zf-C2H2 PF00096.26 KOS16678.1 - 0.012 16.0 2.6 0.012 16.0 2.6 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KOS16678.1 - 0.039 13.7 9.2 0.047 13.5 0.6 3.3 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 KOS16678.1 - 9.4 7.4 17.7 0.37 11.7 1.9 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger FMN_dh PF01070.18 KOS16679.1 - 6.5e-114 380.6 0.0 7.5e-114 380.4 0.0 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 KOS16679.1 - 2.1e-06 27.4 1.4 2.8e-06 27.0 0.7 1.5 2 0 0 2 2 2 1 Nitronate monooxygenase ThiG PF05690.14 KOS16679.1 - 0.00066 19.1 1.2 0.19 11.0 0.2 2.6 3 0 0 3 3 3 2 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 KOS16679.1 - 0.00076 18.6 3.4 0.087 11.8 0.9 3.1 2 1 1 3 3 3 2 IMP dehydrogenase / GMP reductase domain Glu_synthase PF01645.17 KOS16679.1 - 0.0015 17.7 0.3 0.0031 16.7 0.3 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase DUF599 PF04654.12 KOS16679.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Far-17a_AIG1 PF04750.14 KOS16680.1 - 2.2e-42 144.7 12.7 2.5e-42 144.5 12.7 1.0 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein DUF5053 PF16476.5 KOS16680.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5053) WD40 PF00400.32 KOS16681.1 - 7.9e-06 26.5 0.1 2.2 9.3 0.0 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS16681.1 - 0.00012 22.3 0.0 0.085 13.2 0.0 4.5 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain SLD5_C PF16922.5 KOS16682.1 - 4e-14 52.5 0.0 6.8e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 KOS16682.1 - 1.7e-08 34.9 0.2 4.1e-08 33.7 0.2 1.7 1 0 0 1 1 1 1 GINS complex protein FAD_binding_3 PF01494.19 KOS16683.1 - 1.2e-63 215.5 0.0 1.5e-63 215.2 0.0 1.1 1 0 0 1 1 1 1 FAD binding domain Phe_hydrox_dim PF07976.12 KOS16683.1 - 1e-27 97.2 0.0 1.8e-27 96.4 0.0 1.4 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain Pyr_redox_2 PF07992.14 KOS16683.1 - 2.3e-05 23.8 0.0 0.00047 19.5 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS16683.1 - 2.9e-05 24.5 0.0 0.0038 17.7 0.0 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOS16683.1 - 0.00011 21.0 0.0 0.00018 20.4 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 KOS16683.1 - 0.00023 20.3 0.3 0.00057 19.1 0.2 1.7 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KOS16683.1 - 0.0012 19.0 0.0 0.003 17.7 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS16683.1 - 0.0042 16.7 0.0 0.04 13.5 0.0 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 KOS16683.1 - 0.024 13.9 0.0 0.04 13.1 0.0 1.2 1 0 0 1 1 1 0 Thi4 family AlaDh_PNT_C PF01262.21 KOS16683.1 - 0.031 13.6 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 KOS16683.1 - 0.034 13.4 0.0 0.063 12.5 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS16683.1 - 0.053 12.4 0.0 0.11 11.3 0.0 1.5 1 1 0 1 1 1 0 Tryptophan halogenase GIDA PF01134.22 KOS16683.1 - 0.11 11.6 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 KOS16683.1 - 0.13 11.3 0.1 0.22 10.6 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 KOS16683.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 FAD-NAD(P)-binding 3HCDH_N PF02737.18 KOS16683.1 - 0.23 11.3 0.0 0.51 10.2 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Indigoidine_A PF04227.12 KOS16684.1 - 5.4e-109 364.0 0.6 7.8e-109 363.5 0.6 1.2 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 KOS16684.1 - 1.1e-19 70.8 0.4 1.3e-10 41.1 0.0 2.7 2 1 0 2 2 2 2 pfkB family carbohydrate kinase Calreticulin PF00262.18 KOS16685.1 - 5.1e-166 552.0 15.5 6.3e-166 551.7 15.5 1.1 1 0 0 1 1 1 1 Calreticulin family Aldedh PF00171.22 KOS16686.1 - 9.1e-132 439.8 0.1 1.1e-131 439.6 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 KOS16686.1 - 0.018 14.1 0.0 0.027 13.5 0.0 1.2 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) Aldolase_II PF00596.21 KOS16687.1 - 1.2e-42 146.0 0.0 1.4e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain GCSF PF16647.5 KOS16687.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Granulocyte colony-stimulating factor RAP1 PF07218.11 KOS16688.1 - 5.9 5.0 15.5 6.9 4.8 15.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CRT10 PF08728.10 KOS16689.1 - 1.5e-11 43.3 0.0 2e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 CRT10 CRT10 PF08728.10 KOS16690.1 - 0.033 12.4 0.0 0.12 10.5 0.0 1.8 2 0 0 2 2 2 0 CRT10 Ammonium_transp PF00909.21 KOS16691.1 - 1.4e-112 376.3 28.0 1.6e-112 376.1 28.0 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Glucan_synthase PF02364.15 KOS16691.1 - 2.1 6.4 3.0 3.5 5.7 3.0 1.4 1 1 0 1 1 1 0 1,3-beta-glucan synthase component His_Phos_2 PF00328.22 KOS16692.1 - 1.9e-44 152.6 0.0 2.3e-44 152.3 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Pkinase PF00069.25 KOS16694.1 - 0.0002 20.8 0.0 0.00031 20.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain RRM_1 PF00076.22 KOS16695.1 - 3e-19 68.6 0.3 5.1e-19 67.9 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS16695.1 - 1.4e-05 24.7 0.0 1.7e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS16695.1 - 0.018 14.9 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Pkinase PF00069.25 KOS16696.1 - 3.5e-42 144.6 0.0 1.3e-41 142.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS16696.1 - 3.2e-14 52.8 0.0 3.8e-13 49.3 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase CCSAP PF15748.5 KOS16696.1 - 2.7 8.1 8.3 4.3 7.4 7.4 1.7 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SR-25 PF10500.9 KOS16696.1 - 9.5 5.8 17.5 4.7 6.8 10.1 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein HhH-GPD PF00730.25 KOS16697.1 - 0.0023 18.4 0.0 0.0048 17.3 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein SURF4 PF02077.15 KOS16698.1 - 4.8e-98 328.0 6.3 5.5e-98 327.8 6.3 1.0 1 0 0 1 1 1 1 SURF4 family DUF4133 PF13571.6 KOS16698.1 - 9.2 6.7 9.7 7.5 7.0 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4133) AIM3 PF17096.5 KOS16699.1 - 0.012 16.6 13.2 0.012 16.5 0.0 3.6 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 TCTP PF00838.17 KOS16700.1 - 3.2e-68 229.3 1.7 3.6e-68 229.1 1.7 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein Nse4-Nse3_bdg PF15412.6 KOS16700.1 - 0.1 12.7 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 Binding domain of Nse4/EID3 to Nse3-MAGE Sel1 PF08238.12 KOS16702.1 - 4.6e-10 39.8 0.9 0.00069 20.2 0.1 3.1 3 0 0 3 3 3 2 Sel1 repeat TraC PF07820.12 KOS16702.1 - 0.054 13.8 0.8 0.72 10.2 0.0 2.8 2 0 0 2 2 2 0 TraC-like protein bZIP_1 PF00170.21 KOS16703.1 - 3.2e-10 40.0 17.8 8.9e-10 38.5 12.7 2.4 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 KOS16703.1 - 1.3e-05 25.7 12.2 1.5e-05 25.4 10.7 1.9 1 1 0 1 1 1 1 bZIP Maf transcription factor bZIP_2 PF07716.15 KOS16703.1 - 3.4e-05 23.8 9.1 3.4e-05 23.8 9.1 2.5 2 1 0 2 2 2 1 Basic region leucine zipper DUF737 PF05300.11 KOS16703.1 - 0.0075 16.6 3.7 0.014 15.8 3.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF737) UPF0242 PF06785.11 KOS16703.1 - 0.023 14.8 16.2 0.044 13.9 16.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 KOS16703.1 - 0.38 9.3 9.8 0.55 8.8 9.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A KASH_CCD PF14662.6 KOS16703.1 - 0.52 10.1 16.8 1 9.1 16.8 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PEP-utilisers_N PF05524.13 KOS16703.1 - 0.63 10.2 4.6 0.51 10.5 2.3 2.2 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal Ndc1_Nup PF09531.10 KOS16703.1 - 0.78 8.4 3.9 1.4 7.5 3.9 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3450 PF11932.8 KOS16703.1 - 2 7.7 11.1 4.5 6.5 11.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Prominin PF05478.11 KOS16703.1 - 2.3 6.1 9.2 3.7 5.4 9.2 1.2 1 0 0 1 1 1 0 Prominin V_ATPase_I PF01496.19 KOS16703.1 - 3.2 5.5 5.9 4.7 5.0 5.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Spc7 PF08317.11 KOS16703.1 - 4.2 6.2 16.6 6.8 5.5 16.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5320 PF17253.2 KOS16703.1 - 5.2 8.2 7.2 10 7.2 0.6 2.8 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Sua5_yciO_yrdC PF01300.18 KOS16704.1 - 8.6e-53 178.5 0.0 1.8e-52 177.5 0.0 1.5 1 1 0 1 1 1 1 Telomere recombination SUA5 PF03481.13 KOS16704.1 - 6.9e-28 97.9 0.0 1.1e-27 97.2 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding COG4 PF08318.12 KOS16705.1 - 3.5e-119 397.8 0.0 4.8e-119 397.4 0.0 1.2 1 0 0 1 1 1 1 COG4 transport protein E1-E2_ATPase PF00122.20 KOS16705.1 - 2.5e-45 154.2 0.1 7.2e-45 152.7 0.1 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOS16705.1 - 1.3e-44 152.1 0.2 2.3e-44 151.3 0.2 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOS16705.1 - 5.2e-21 75.9 1.8 6.8e-20 72.3 1.8 2.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOS16705.1 - 6.7e-20 70.5 0.0 1.7e-19 69.2 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Cation_ATPase PF13246.6 KOS16705.1 - 2.2e-12 46.9 0.0 5.1e-12 45.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOS16705.1 - 0.00019 21.3 1.6 0.0005 19.9 0.6 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Frankia_peptide PF14407.6 KOS16705.1 - 0.2 11.7 2.2 0.7 9.9 0.2 2.4 2 0 0 2 2 2 0 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. DUF3246 PF11596.8 KOS16705.1 - 0.31 10.5 3.4 0.64 9.4 3.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) MCM PF00493.23 KOS16706.1 - 2.4e-101 337.5 0.0 3.8e-101 336.9 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOS16706.1 - 3.5e-39 133.5 0.6 6.2e-39 132.7 0.6 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOS16706.1 - 3.4e-28 97.9 3.0 7.8e-28 96.7 3.0 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOS16706.1 - 2.7e-19 69.7 0.1 1e-18 67.8 0.1 1.9 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 KOS16706.1 - 1.1e-05 25.5 0.1 7.5e-05 22.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 KOS16706.1 - 1.1e-05 24.9 0.0 0.00046 19.6 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOS16706.1 - 0.0018 18.2 0.0 0.0092 15.8 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ArnB_C PF18677.1 KOS16706.1 - 9.9 6.4 11.3 6.9 6.9 0.3 3.2 2 1 2 4 4 4 0 Archaellum regulatory network B, C-terminal domain Clat_adaptor_s PF01217.20 KOS16707.1 - 2.3e-15 56.8 1.0 1.9e-14 53.8 1.0 1.9 1 1 0 1 1 1 1 Clathrin adaptor complex small chain THOC7 PF05615.13 KOS16708.1 - 3.6e-44 150.2 0.9 4.7e-43 146.6 0.0 2.1 1 1 1 2 2 2 1 Tho complex subunit 7 Sporozoite_P67 PF05642.11 KOS16708.1 - 0.00089 17.5 0.0 0.0035 15.5 0.0 1.8 1 1 1 2 2 2 1 Sporozoite P67 surface antigen zf-CCCH PF00642.24 KOS16709.1 - 7e-06 25.8 27.5 0.021 14.8 0.2 5.3 4 1 1 5 5 5 4 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOS16709.1 - 0.00068 19.6 37.7 0.0032 17.5 1.8 5.9 5 1 0 5 5 5 3 Zinc finger domain zf-CCCH_4 PF18044.1 KOS16709.1 - 0.0016 18.2 0.4 0.0016 18.2 0.4 4.5 5 0 0 5 5 5 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 KOS16709.1 - 0.078 13.2 0.6 0.078 13.2 0.6 3.5 2 2 1 3 3 3 0 Zinc-finger containing family Torus PF16131.5 KOS16709.1 - 0.097 13.4 0.6 0.097 13.4 0.6 5.2 2 1 4 6 6 6 0 Torus domain zf-C3H1 PF10650.9 KOS16709.1 - 9.3 6.1 9.4 33 4.3 0.0 4.1 4 0 0 4 4 4 0 Putative zinc-finger domain Rad21_Rec8_N PF04825.13 KOS16710.1 - 6.2e-38 129.4 0.0 1.2e-37 128.4 0.0 1.4 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KOS16710.1 - 1.5e-08 33.8 0.0 2.9e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein TBCA PF02970.16 KOS16711.1 - 1.1e-21 76.9 2.0 1.8e-21 76.3 0.9 1.7 1 1 1 2 2 2 1 Tubulin binding cofactor A OmpH PF03938.14 KOS16711.1 - 0.0026 18.1 6.3 0.0043 17.4 0.5 2.0 1 1 1 2 2 2 1 Outer membrane protein (OmpH-like) Rx_N PF18052.1 KOS16711.1 - 0.012 15.9 1.5 0.046 14.0 0.4 2.0 2 0 0 2 2 2 0 Rx N-terminal domain DUF2408 PF10303.9 KOS16711.1 - 0.046 14.3 0.3 0.066 13.8 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF4618 PF15397.6 KOS16711.1 - 0.065 12.6 0.5 0.096 12.1 0.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) APC_N_CC PF16689.5 KOS16711.1 - 0.075 13.1 0.4 0.16 12.1 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain APG6_N PF17675.1 KOS16711.1 - 0.31 11.6 7.5 2.3 8.8 0.2 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Seryl_tRNA_N PF02403.22 KOS16711.1 - 0.83 9.9 5.6 6.1 7.1 0.1 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FAD_binding_4 PF01565.23 KOS16713.1 - 1.8e-21 76.3 0.6 4.4e-21 75.1 0.6 1.7 1 0 0 1 1 1 1 FAD binding domain HET PF06985.11 KOS16714.1 - 3.3e-12 47.0 0.0 2.6e-08 34.3 0.0 2.3 2 0 0 2 2 2 2 Heterokaryon incompatibility protein (HET) DUF4556 PF15094.6 KOS16715.1 - 0.13 11.4 0.0 0.21 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4556) Glyco_hydro_3_C PF01915.22 KOS16716.1 - 5.1e-44 150.7 0.0 7.7e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS16716.1 - 1.9e-42 145.8 0.0 3.3e-42 145.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS16716.1 - 6.9e-26 90.2 0.1 1.3e-25 89.3 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_75 PF07335.11 KOS16717.1 - 4.8e-62 209.0 1.2 7.1e-62 208.5 1.2 1.3 1 0 0 1 1 1 1 Fungal chitosanase of glycosyl hydrolase group 75 LCM PF04072.14 KOS16719.1 - 5.3e-16 59.1 0.0 1.3e-15 57.8 0.0 1.6 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase adh_short_C2 PF13561.6 KOS16720.1 - 9.8e-57 192.2 0.0 1.3e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS16720.1 - 4.4e-46 156.8 0.1 5.6e-46 156.5 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS16720.1 - 5.5e-13 49.2 0.0 7.8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 KOS16720.1 - 3.1e-05 23.5 0.0 4.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 KOS16720.1 - 0.049 12.7 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Glyco_hydro_47 PF01532.20 KOS16721.1 - 9.7e-168 558.8 0.0 1.1e-167 558.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 AA_permease PF00324.21 KOS16722.1 - 2.2e-142 475.0 32.7 2.6e-142 474.8 32.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS16722.1 - 1.4e-36 126.3 35.1 1.7e-36 126.0 35.1 1.1 1 0 0 1 1 1 1 Amino acid permease T_cell_tran_alt PF15128.6 KOS16722.1 - 0.095 12.5 0.1 5.9 6.8 0.0 2.6 1 1 1 2 2 2 0 T-cell leukemia translocation-altered CAP59_mtransfer PF11735.8 KOS16723.1 - 1.6e-85 286.7 0.0 1.9e-85 286.4 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 PMT PF02366.18 KOS16724.1 - 3.1e-83 279.1 14.7 5.2e-83 278.4 14.7 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOS16724.1 - 6.3e-67 225.0 6.7 6.3e-67 225.0 6.7 2.8 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOS16724.1 - 1.2e-19 70.9 1.1 2.3e-19 70.0 1.1 1.4 1 0 0 1 1 1 1 MIR domain PMT_2 PF13231.6 KOS16724.1 - 0.00091 19.5 8.5 0.0029 17.9 7.8 2.3 1 1 1 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase RAMP4 PF06624.12 KOS16724.1 - 0.07 13.2 0.1 1.1 9.4 0.1 2.6 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF5320 PF17253.2 KOS16725.1 - 0.041 14.9 0.0 0.09 13.9 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Carb_kinase PF01256.17 KOS16726.1 - 2.9e-47 161.2 1.8 1.4e-45 155.6 1.8 2.8 1 1 0 1 1 1 1 Carbohydrate kinase Homeodomain PF00046.29 KOS16727.1 - 2.7e-06 27.1 0.2 3.6e-06 26.7 0.2 1.1 1 0 0 1 1 1 1 Homeodomain NAD_kinase PF01513.21 KOS16728.1 - 1.6e-78 263.9 0.0 2e-78 263.6 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase RNase_PH PF01138.21 KOS16729.1 - 1.7e-12 48.0 0.0 2.7e-12 47.3 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 PTPA PF03095.15 KOS16730.1 - 1.1e-107 360.0 0.0 1.3e-107 359.7 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein SPX PF03105.19 KOS16730.1 - 0.32 10.9 2.0 0.51 10.2 2.0 1.2 1 0 0 1 1 1 0 SPX domain NuA4 PF09340.10 KOS16731.1 - 1.7e-24 85.5 1.3 2.3e-24 85.0 0.1 1.7 2 0 0 2 2 2 1 Histone acetyltransferase subunit NuA4 DHR10 PF18595.1 KOS16731.1 - 0.045 13.8 0.4 0.073 13.1 0.4 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain PWI PF01480.17 KOS16732.1 - 1.6e-31 108.4 0.0 2.7e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 PWI domain Nas2_N PF18265.1 KOS16733.1 - 7.7e-30 102.6 0.0 1.1e-29 102.2 0.0 1.2 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 KOS16733.1 - 1.3e-06 28.1 0.0 2.4e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 KOS16733.1 - 3.3e-05 24.1 0.0 5.9e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 KOS16733.1 - 0.0013 19.1 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 PDZ domain RRM_1 PF00076.22 KOS16733.1 - 0.0038 17.0 0.0 0.013 15.3 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1048 PF06304.11 KOS16733.1 - 0.16 12.4 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1048) Ras PF00071.22 KOS16734.1 - 2e-49 167.3 0.1 2.4e-49 167.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS16734.1 - 1.3e-30 106.1 0.0 5.6e-30 104.0 0.0 1.8 1 1 1 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS16734.1 - 2.5e-11 43.3 0.0 3.5e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RNA_helicase PF00910.22 KOS16734.1 - 3.8e-05 24.0 0.1 0.0016 18.8 0.1 2.3 1 1 0 1 1 1 1 RNA helicase MMR_HSR1 PF01926.23 KOS16734.1 - 8.3e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS16734.1 - 0.00057 19.3 0.0 0.00072 19.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 KOS16734.1 - 0.003 16.8 2.1 2.5 7.2 0.1 3.0 2 1 0 3 3 3 1 G-protein alpha subunit AAA_7 PF12775.7 KOS16734.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 KOS16734.1 - 0.014 15.3 0.1 4.4 7.2 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase SRPRB PF09439.10 KOS16734.1 - 0.022 14.2 0.0 0.037 13.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 KOS16734.1 - 0.024 15.0 0.1 0.084 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain Pox_A32 PF04665.12 KOS16734.1 - 0.031 13.7 0.1 0.06 12.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein AAA_24 PF13479.6 KOS16734.1 - 0.036 13.8 0.1 0.062 13.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOS16734.1 - 0.051 13.6 0.1 0.11 12.5 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOS16734.1 - 0.078 13.1 1.0 0.11 12.6 0.2 1.7 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 KOS16734.1 - 0.14 11.4 0.2 0.3 10.3 0.0 1.6 2 0 0 2 2 2 0 Septin ATPase PF06745.13 KOS16734.1 - 0.15 11.3 0.1 0.23 10.8 0.1 1.2 1 0 0 1 1 1 0 KaiC GTP_EFTU PF00009.27 KOS16734.1 - 0.21 11.1 1.1 0.83 9.2 0.0 2.1 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain Lipase_3 PF01764.25 KOS16735.1 - 1.6e-06 28.0 0.0 3.2e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOS16735.1 - 0.0047 16.2 0.0 0.0076 15.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS16735.1 - 0.04 13.5 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 KOS16735.1 - 0.054 13.3 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family UPF0227 PF05728.12 KOS16735.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) YL1 PF05764.13 KOS16736.1 - 1e-70 238.7 27.8 1e-70 238.7 27.8 3.3 3 0 0 3 3 3 2 YL1 nuclear protein YL1_C PF08265.11 KOS16736.1 - 1.1e-15 57.0 0.3 1.8e-15 56.4 0.3 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain Vezatin PF12632.7 KOS16737.1 - 6.6e-68 229.1 0.0 1.2e-67 228.2 0.0 1.4 1 0 0 1 1 1 1 Mysoin-binding motif of peroxisomes PCNA_N PF00705.18 KOS16738.1 - 5.2e-54 181.3 3.1 1.1e-53 180.3 3.1 1.5 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 KOS16738.1 - 5.3e-50 168.9 0.1 1.9e-48 163.8 0.0 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad9 PF04139.13 KOS16738.1 - 7.2e-08 32.2 0.0 9.1e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 Rad9 Rad1 PF02144.16 KOS16738.1 - 3.7e-07 29.5 0.2 3.4e-05 23.1 0.2 2.0 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Hus1 PF04005.12 KOS16738.1 - 0.00017 20.9 0.2 0.0006 19.0 0.1 1.9 1 1 1 2 2 2 1 Hus1-like protein DNA_pol3_beta_3 PF02768.15 KOS16738.1 - 0.0014 18.4 0.1 0.088 12.6 0.0 2.7 2 1 1 3 3 3 1 DNA polymerase III beta subunit, C-terminal domain ZapB PF06005.12 KOS16739.1 - 0.00026 21.4 13.1 0.37 11.3 0.4 4.1 2 1 1 3 3 3 2 Cell division protein ZapB PKcGMP_CC PF16808.5 KOS16739.1 - 0.0043 16.9 2.2 0.0043 16.9 2.2 3.1 3 0 0 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Csm1_N PF18504.1 KOS16739.1 - 0.0049 17.2 7.7 6 7.3 0.7 3.9 2 1 0 2 2 2 2 Csm1 N-terminal domain GIT_CC PF16559.5 KOS16739.1 - 0.016 15.1 9.8 0.96 9.4 0.3 3.6 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fib_alpha PF08702.10 KOS16739.1 - 0.017 15.3 4.7 0.019 15.2 1.3 2.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Tropomyosin_1 PF12718.7 KOS16739.1 - 0.021 15.0 0.7 0.021 15.0 0.7 2.5 2 0 0 2 2 2 0 Tropomyosin like DUF5082 PF16888.5 KOS16739.1 - 0.026 14.8 8.3 0.42 10.9 0.9 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) EMP24_GP25L PF01105.24 KOS16739.1 - 0.031 14.2 1.2 0.13 12.2 0.2 2.3 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Shugoshin_N PF07558.11 KOS16739.1 - 0.038 13.9 0.8 0.038 13.9 0.8 3.3 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region DivIC PF04977.15 KOS16739.1 - 0.1 12.4 16.5 0.14 12.0 1.3 3.8 2 1 1 3 3 3 0 Septum formation initiator Lebercilin PF15619.6 KOS16739.1 - 0.22 11.1 13.0 0.75 9.4 13.0 1.9 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 KOS16739.1 - 0.3 11.6 2.7 48 4.5 2.7 3.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein TSC22 PF01166.18 KOS16739.1 - 0.35 11.2 5.9 2.1 8.7 0.1 3.4 3 0 0 3 3 3 0 TSC-22/dip/bun family Phage_GP20 PF06810.11 KOS16739.1 - 0.35 10.7 7.1 0.78 9.5 6.3 1.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF4407 PF14362.6 KOS16739.1 - 0.36 10.1 11.9 0.77 9.0 11.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GrpE PF01025.19 KOS16739.1 - 0.83 9.3 9.7 0.92 9.1 0.6 3.2 3 0 0 3 3 3 0 GrpE Seryl_tRNA_N PF02403.22 KOS16739.1 - 1.5 9.1 9.5 11 6.3 2.9 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Syntaxin-6_N PF09177.11 KOS16739.1 - 1.7 9.3 5.8 7.2 7.2 0.4 3.4 2 1 0 3 3 3 0 Syntaxin 6, N-terminal bZIP_1 PF00170.21 KOS16739.1 - 1.7 8.8 11.4 0.51 10.5 0.7 3.3 3 0 0 3 3 3 0 bZIP transcription factor TMF_DNA_bd PF12329.8 KOS16739.1 - 2.2 8.3 15.8 1.6 8.8 1.7 3.7 3 1 1 4 4 3 0 TATA element modulatory factor 1 DNA binding Phage_Mu_Gam PF07352.12 KOS16739.1 - 2.4 8.1 7.0 13 5.7 0.9 2.4 2 0 0 2 2 2 0 Bacteriophage Mu Gam like protein ADIP PF11559.8 KOS16739.1 - 3.1 7.9 18.4 3.7 7.6 2.6 2.7 2 1 1 3 3 2 0 Afadin- and alpha -actinin-Binding FAM76 PF16046.5 KOS16739.1 - 6 6.1 8.8 7.5 5.8 1.0 2.5 2 1 0 2 2 2 0 FAM76 protein Uds1 PF15456.6 KOS16739.1 - 7.6 6.7 12.9 1.6 8.9 6.3 2.7 1 1 1 2 2 2 0 Up-regulated During Septation SlyX PF04102.12 KOS16739.1 - 8.5 7.1 21.0 0.47 11.1 2.8 4.6 3 1 1 4 4 3 0 SlyX Stathmin PF00836.19 KOS16739.1 - 8.6 6.3 9.4 1.8 8.5 1.4 2.7 3 0 0 3 3 3 0 Stathmin family pPIWI_RE_Z PF18155.1 KOS16740.1 - 0.055 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 pPIWI RE three-gene island domain Z DUF1460 PF07313.12 KOS16740.1 - 0.2 11.0 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1460) Phos_pyr_kin PF08543.12 KOS16745.1 - 1.4e-09 37.7 0.0 2.4e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 KOS16745.1 - 9.5e-07 28.4 0.1 5.1e-06 26.0 0.0 2.0 2 0 0 2 2 2 1 pfkB family carbohydrate kinase CENP-K PF11802.8 KOS16746.1 - 3.2e-07 30.2 1.5 0.055 13.0 3.3 2.6 2 1 0 2 2 2 2 Centromere-associated protein K MIF4G_like_2 PF09090.11 KOS16746.1 - 1.1 8.6 15.4 0.99 8.8 1.8 2.8 2 1 0 2 2 2 0 MIF4G like ResIII PF04851.15 KOS16747.1 - 1.8e-22 80.1 1.9 3.9e-22 79.0 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOS16747.1 - 1.8e-21 76.5 0.3 9.4e-21 74.2 0.1 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS16747.1 - 3.4e-17 62.8 0.0 7e-17 61.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase SR-25 PF10500.9 KOS16747.1 - 0.00047 19.8 8.1 0.00047 19.8 8.1 3.4 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein AAA_22 PF13401.6 KOS16747.1 - 0.0019 18.5 0.0 0.0081 16.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain RAC_head PF16717.5 KOS16747.1 - 0.027 15.4 1.9 0.027 15.4 1.9 3.5 3 0 0 3 3 3 0 Ribosome-associated complex head domain SNF2_N PF00176.23 KOS16747.1 - 0.085 11.6 0.0 0.21 10.2 0.0 1.7 1 0 0 1 1 1 0 SNF2 family N-terminal domain BUD22 PF09073.10 KOS16747.1 - 0.48 9.7 29.1 0.017 14.5 20.9 2.1 2 0 0 2 2 2 0 BUD22 LSM PF01423.22 KOS16748.1 - 4.6e-14 51.9 0.3 5.4e-14 51.6 0.3 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOS16748.1 - 0.0043 16.7 0.1 0.0064 16.1 0.1 1.3 1 0 0 1 1 1 1 Hfq protein PhnA PF03831.14 KOS16748.1 - 0.068 13.1 0.1 0.94 9.4 0.0 2.2 2 0 0 2 2 2 0 PhnA domain Ribosomal_L30_N PF08079.12 KOS16751.1 - 3e-26 91.5 18.0 4.9e-26 90.8 18.0 1.3 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 KOS16751.1 - 1.6e-17 63.1 2.8 1.6e-17 63.1 2.8 2.1 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Tipalpha PF16753.5 KOS16751.1 - 0.1 12.4 0.0 0.1 12.4 0.0 2.3 1 1 1 2 2 2 0 TNF-alpha-Inducing protein of Helicobacter PEX11 PF05648.14 KOS16752.1 - 0.013 15.0 5.1 0.52 9.7 0.2 2.9 2 1 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) eIF-3c_N PF05470.12 KOS16753.1 - 2.7e-171 570.9 19.3 2.7e-171 570.9 19.3 2.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 KOS16753.1 - 1.6e-13 51.1 0.4 1.4e-12 48.1 0.0 2.6 2 0 0 2 2 2 1 PCI domain DUF2779 PF11074.8 KOS16753.1 - 0.049 14.1 0.3 0.5 10.9 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function(DUF2779) Nup54_57_C PF18570.1 KOS16753.1 - 0.079 12.6 5.8 0.2 11.2 5.8 1.7 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain CDC45 PF02724.14 KOS16753.1 - 1.3 7.2 13.8 2.1 6.6 13.8 1.2 1 0 0 1 1 1 0 CDC45-like protein ApbA_C PF08546.11 KOS16754.1 - 1.8e-25 89.6 0.0 3.3e-25 88.7 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 KOS16754.1 - 2.8e-21 75.7 0.0 5.3e-21 74.9 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA PROCN PF08083.11 KOS16755.1 - 3.4e-234 776.9 8.8 3.4e-234 776.9 8.8 1.9 2 0 0 2 2 2 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 KOS16755.1 - 1.9e-126 420.3 1.1 3.5e-126 419.4 1.1 1.4 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 KOS16755.1 - 1.1e-88 295.2 1.4 6.2e-88 292.8 1.6 2.3 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 KOS16755.1 - 3.4e-78 260.8 3.6 3.4e-78 260.8 3.6 1.9 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 KOS16755.1 - 8e-71 236.4 0.1 1.6e-70 235.4 0.1 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 KOS16755.1 - 2.4e-46 156.0 0.1 7.7e-46 154.4 0.1 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 KOS16755.1 - 9.3e-45 151.5 0.3 2.6e-44 150.1 0.0 2.0 2 0 0 2 2 2 1 PROCT (NUC072) domain Ribosomal_S11 PF00411.19 KOS16756.1 - 1.8e-46 157.1 1.6 2.3e-46 156.7 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Pilus_CpaD PF09476.10 KOS16756.1 - 0.046 13.4 0.1 0.057 13.1 0.1 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) CBM_25 PF03423.13 KOS16756.1 - 0.1 12.9 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) DUF2252 PF10009.9 KOS16756.1 - 0.1 11.6 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) SNF2_N PF00176.23 KOS16757.1 - 1.3e-67 228.0 0.0 2.4e-67 227.1 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS16757.1 - 2.1e-15 57.0 0.0 4.9e-15 55.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS16757.1 - 9e-07 29.0 0.0 2.1e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOS16757.1 - 0.0021 17.3 0.0 0.0053 16.0 0.0 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 PALP PF00291.25 KOS16758.1 - 4.8e-41 141.1 1.3 5.9e-41 140.8 1.3 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme MFS_1 PF07690.16 KOS16759.1 - 7.5e-29 100.7 13.2 1.2e-28 100.1 13.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS16759.1 - 1.7e-06 27.2 6.1 7.2e-06 25.1 6.1 1.8 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOS16759.1 - 0.0003 19.7 2.6 0.0058 15.5 4.6 2.0 2 0 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 KOS16759.1 - 0.0018 16.8 1.5 0.0028 16.1 1.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MHYT PF03707.16 KOS16759.1 - 0.92 9.7 9.4 1.7 8.9 0.1 3.4 3 1 1 4 4 4 0 Bacterial signalling protein N terminal repeat DUF2530 PF10745.9 KOS16759.1 - 1.7 9.0 5.6 1.6 9.0 1.0 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF2530) AA_permease PF00324.21 KOS16760.1 - 3.6e-124 415.0 30.5 4.1e-124 414.8 30.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS16760.1 - 1.5e-31 109.7 36.0 1.8e-31 109.5 36.0 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1860 PF08949.10 KOS16760.1 - 0.38 10.4 2.7 0.7 9.6 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1860) Peptidase_S8 PF00082.22 KOS16761.1 - 3.5e-21 75.7 8.4 8.1e-21 74.6 8.4 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOS16761.1 - 1.9e-10 41.2 0.2 1.5e-09 38.4 0.0 2.5 2 1 0 2 2 2 1 Peptidase inhibitor I9 Abhydrolase_3 PF07859.13 KOS16762.1 - 2.6e-30 105.9 0.0 3.6e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOS16762.1 - 0.0065 15.4 0.0 0.0081 15.1 0.0 1.1 1 0 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 KOS16762.1 - 0.049 12.5 0.0 0.063 12.1 0.0 1.1 1 0 0 1 1 1 0 Carboxylesterase family Pro-kuma_activ PF09286.11 KOS16763.1 - 9e-48 162.2 0.0 1.5e-47 161.5 0.0 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain PRIMA1 PF16101.5 KOS16765.1 - 0.28 11.2 3.1 0.49 10.4 3.1 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Paf67 PF10255.9 KOS16766.1 - 2.7e-155 517.3 0.4 3.2e-155 517.1 0.4 1.0 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 TPR_2 PF07719.17 KOS16766.1 - 0.046 13.8 0.0 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Usp PF00582.26 KOS16767.1 - 5.4e-16 59.4 1.1 7.1e-15 55.8 0.0 2.6 3 0 0 3 3 3 1 Universal stress protein family PGA2 PF07543.12 KOS16767.1 - 0.23 11.4 8.1 0.35 10.8 1.8 3.0 3 0 0 3 3 3 0 Protein trafficking PGA2 ABA_GPCR PF12430.8 KOS16768.1 - 1.4e-47 161.8 0.1 3.6e-47 160.4 0.0 1.8 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 KOS16768.1 - 5.8e-23 80.8 0.3 1.8e-22 79.2 0.0 2.0 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal NUDIX PF00293.28 KOS16769.1 - 3.1e-13 49.9 2.4 2.5e-11 43.7 0.4 2.4 1 1 0 2 2 2 2 NUDIX domain RRM_1 PF00076.22 KOS16770.1 - 2.2e-12 46.6 0.0 4.2e-12 45.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATG16 PF08614.11 KOS16771.1 - 6.7e-56 189.7 21.5 7.5e-56 189.5 21.5 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 KOS16771.1 - 0.00026 20.5 9.9 0.00029 20.4 9.9 1.2 1 0 0 1 1 1 1 Golgin subfamily A member 5 UPF0242 PF06785.11 KOS16771.1 - 0.0054 16.9 14.4 0.0072 16.5 3.5 2.5 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 KOS16771.1 - 0.017 15.6 20.8 0.031 14.8 15.6 2.7 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF3584 PF12128.8 KOS16771.1 - 0.03 11.9 12.7 0.041 11.4 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CCDC144C PF14915.6 KOS16771.1 - 0.052 12.7 15.8 0.14 11.2 12.8 2.1 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region SurA_N PF09312.11 KOS16771.1 - 0.053 13.6 4.1 0.056 13.5 2.8 1.7 2 0 0 2 2 2 0 SurA N-terminal domain MPS2 PF17060.5 KOS16771.1 - 0.13 11.5 7.6 0.15 11.3 7.6 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4201 PF13870.6 KOS16771.1 - 0.14 11.9 17.4 0.016 14.9 12.8 1.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 KOS16771.1 - 0.27 10.6 13.3 1.6 8.0 11.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 KOS16771.1 - 0.72 9.4 8.2 0.8 9.2 8.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SlyX PF04102.12 KOS16771.1 - 0.89 10.2 12.6 1.3 9.6 2.4 3.5 2 1 1 3 3 3 0 SlyX Atg14 PF10186.9 KOS16771.1 - 0.93 8.5 14.2 1.3 8.1 14.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 KOS16771.1 - 6.3 5.6 16.6 15 4.4 16.0 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein DOT1 PF08123.13 KOS16772.1 - 2.9e-74 249.0 0.4 7.4e-74 247.7 0.2 1.7 2 0 0 2 2 2 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 KOS16772.1 - 0.014 16.1 0.1 0.03 15.0 0.1 1.6 1 0 0 1 1 1 0 Methyltransferase domain Proteasome PF00227.26 KOS16773.1 - 1.9e-46 158.0 0.0 1.2e-31 109.7 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 KOS16773.1 - 6.6e-11 41.7 0.7 9.2e-11 41.2 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature PBP1_TM PF14812.6 KOS16773.1 - 1.2 9.5 6.8 2.3 8.7 6.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM131 PF15010.6 KOS16774.1 - 0.023 14.6 1.6 0.033 14.1 1.6 1.4 1 1 0 1 1 1 0 Putative cell signalling DUF202 PF02656.15 KOS16775.1 - 1.1e-05 25.8 3.9 1.1e-05 25.8 3.9 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF202) FtsX PF02687.21 KOS16775.1 - 0.026 15.0 1.9 0.034 14.6 1.9 1.2 1 0 0 1 1 1 0 FtsX-like permease family TctB PF07331.11 KOS16775.1 - 0.046 14.0 3.0 0.11 12.7 3.1 1.4 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF4282 PF14110.6 KOS16775.1 - 0.089 13.5 3.6 0.14 12.9 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) Abhydrolase_6 PF12697.7 KOS16776.1 - 2.4e-21 77.3 6.6 4.5e-21 76.5 6.6 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS16776.1 - 1.2e-09 38.2 0.0 7.5e-09 35.6 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS16776.1 - 2e-05 24.0 0.0 5.1e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 KOS16776.1 - 0.0086 16.2 0.4 0.061 13.5 0.1 2.2 2 0 0 2 2 2 1 TAP-like protein Abhydrolase_5 PF12695.7 KOS16776.1 - 0.18 11.6 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family CFEM PF05730.11 KOS16777.1 - 8.5e-14 51.4 12.1 1.5e-13 50.6 12.1 1.4 1 0 0 1 1 1 1 CFEM domain Ribul_P_3_epim PF00834.19 KOS16778.1 - 1.4e-57 194.3 0.0 1.6e-56 190.9 0.0 2.3 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family OMPdecase PF00215.24 KOS16778.1 - 0.012 15.2 0.1 0.033 13.8 0.1 1.7 2 0 0 2 2 2 0 Orotidine 5'-phosphate decarboxylase / HUMPS family ThiG PF05690.14 KOS16778.1 - 0.16 11.3 0.2 0.25 10.6 0.2 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG HET PF06985.11 KOS16779.1 - 1.4e-12 48.2 0.3 2.2e-12 47.6 0.3 1.3 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Tetraspanin PF00335.20 KOS16779.1 - 0.56 9.9 1.9 1 9.0 1.9 1.3 1 0 0 1 1 1 0 Tetraspanin family VPS9 PF02204.18 KOS16780.1 - 2.4e-20 72.7 0.0 4.4e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 KOS16780.1 - 1.9e-15 56.9 0.2 3.6e-15 56.0 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) CUE PF02845.16 KOS16780.1 - 6.2e-09 35.4 0.1 6.2e-08 32.2 0.0 2.2 2 0 0 2 2 2 1 CUE domain YuzL PF14115.6 KOS16780.1 - 0.31 11.5 4.7 2.7 8.5 0.7 2.7 2 0 0 2 2 2 0 YuzL-like protein TRP PF06011.12 KOS16781.1 - 2.5e-129 431.7 16.2 3.3e-129 431.4 16.2 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOS16781.1 - 1.5e-35 122.5 0.3 5.3e-35 120.8 0.9 1.6 2 0 0 2 2 2 1 ML-like domain Pox_A14 PF05767.12 KOS16781.1 - 1.6 8.9 12.6 0.24 11.6 0.3 3.9 4 0 0 4 4 4 0 Poxvirus virion envelope protein A14 zf-C2H2 PF00096.26 KOS16782.1 - 1.4e-06 28.4 20.7 0.00017 21.9 0.3 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS16782.1 - 0.0007 20.2 0.5 0.0007 20.2 0.5 4.6 4 0 0 4 4 4 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOS16782.1 - 0.0077 16.2 0.2 0.0077 16.2 0.2 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger His_Phos_2 PF00328.22 KOS16782.1 - 0.13 11.5 2.1 0.42 9.9 2.0 1.7 1 1 1 2 2 2 0 Histidine phosphatase superfamily (branch 2) FOXP-CC PF16159.5 KOS16782.1 - 0.21 12.2 9.5 0.26 12.0 0.6 3.1 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 KOS16782.1 - 0.43 10.9 7.9 0.076 13.4 1.5 2.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) YdjO PF14169.6 KOS16782.1 - 1.8 8.4 8.2 0.49 10.2 1.5 2.7 2 0 0 2 2 2 0 Cold-inducible protein YdjO TPR_9 PF13371.6 KOS16783.1 - 0.021 15.0 0.0 0.058 13.5 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Sod_Cu PF00080.20 KOS16784.1 - 6.2e-09 36.2 0.1 9.4e-09 35.6 0.1 1.2 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) SR-25 PF10500.9 KOS16784.1 - 3 7.4 14.1 3.9 7.0 14.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MFS_MOT1 PF16983.5 KOS16785.1 - 1.8 9.0 7.1 0.57 10.6 1.3 2.3 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily CAP_N PF01213.19 KOS16786.1 - 0.85 9.0 12.4 5.3 6.4 12.0 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KOS16786.1 - 1.8 8.6 7.7 0.13 12.4 1.8 2.0 2 0 0 2 2 2 0 Mitochondrial fission regulator Glyco_transf_90 PF05686.12 KOS16787.1 - 4.4e-06 25.9 0.6 0.0084 15.1 0.0 3.5 3 1 0 3 3 3 2 Glycosyl transferase family 90 CAP_N PF01213.19 KOS16787.1 - 0.9 9.0 3.9 0.57 9.6 1.6 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal RCDG1 PF15725.5 KOS16787.1 - 6.9 7.2 10.9 0.36 11.3 4.7 2.1 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein p450 PF00067.22 KOS16789.1 - 1.8e-75 254.5 0.0 2.4e-75 254.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Arm PF00514.23 KOS16789.1 - 0.048 13.7 0.0 0.1 12.7 0.0 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat MGC-24 PF05283.11 KOS16790.1 - 0.2 12.1 10.7 0.29 11.6 6.5 2.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Cullin PF00888.22 KOS16791.1 - 1.4e-18 66.9 0.0 2.3e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 Cullin family ANAPC2 PF08672.11 KOS16791.1 - 4.9e-18 65.4 0.0 1e-17 64.4 0.0 1.6 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 DUF3446 PF11928.8 KOS16791.1 - 0.028 14.7 0.1 0.028 14.7 0.1 4.9 4 1 1 5 5 5 0 Early growth response N-terminal domain Pex14_N PF04695.13 KOS16791.1 - 2.1 9.0 13.4 17 6.1 3.7 3.8 4 0 0 4 4 4 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkr1 PF08636.10 KOS16793.1 - 2.9e-29 101.0 7.2 4.1e-29 100.5 7.2 1.2 1 0 0 1 1 1 1 ER protein Pkr1 FSA_C PF10479.9 KOS16793.1 - 0.15 10.1 2.8 0.18 9.9 2.8 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MAJIN PF15077.6 KOS16793.1 - 0.23 11.2 0.1 0.3 10.9 0.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Dicty_REP PF05086.12 KOS16793.1 - 1.2 7.0 2.9 1.3 6.9 2.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-C2H2 PF00096.26 KOS16794.1 - 0.0011 19.3 4.2 0.18 12.3 0.6 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS16794.1 - 0.0059 17.4 2.0 4.2 8.5 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-ribbon_3 PF13248.6 KOS16794.1 - 0.046 13.2 0.1 0.093 12.2 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 KOS16794.1 - 0.06 13.5 0.2 0.13 12.4 0.2 1.6 1 0 0 1 1 1 0 Zinc ribbon domain zf-H2C2_2 PF13465.6 KOS16794.1 - 0.084 13.3 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger double domain Telomerase_RBD PF12009.8 KOS16795.1 - 3.3e-48 163.2 0.5 7e-48 162.1 0.5 1.6 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 KOS16795.1 - 4.1e-14 52.6 0.1 2.9e-12 46.6 0.1 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) NHL PF01436.21 KOS16795.1 - 0.075 13.1 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 NHL repeat RhoGEF PF00621.20 KOS16796.1 - 1e-32 113.9 0.2 1e-32 113.9 0.2 1.9 2 1 0 2 2 2 1 RhoGEF domain BAR PF03114.18 KOS16796.1 - 5.1e-07 29.6 0.9 2.1e-05 24.3 0.1 2.4 2 0 0 2 2 2 1 BAR domain LPD13 PF18825.1 KOS16796.1 - 0.01 15.6 0.4 0.028 14.2 0.1 1.9 2 0 0 2 2 2 1 Large polyvalent protein-associated domain 13 zf-HYPF PF07503.12 KOS16797.1 - 0.061 13.1 2.1 2.6 7.9 0.5 2.5 2 0 0 2 2 2 0 HypF finger Suf PF05843.14 KOS16797.1 - 0.63 10.0 3.7 1.1 9.2 3.7 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MBOAT_2 PF13813.6 KOS16798.1 - 1.4e-13 50.9 5.2 1.4e-13 50.9 5.2 2.1 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family Amino_oxidase PF01593.24 KOS16799.1 - 0.00043 19.7 0.1 0.056 12.7 0.0 2.6 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS16799.1 - 0.001 19.3 6.6 0.0075 16.5 3.1 3.5 3 1 0 3 3 3 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOS16799.1 - 0.0042 15.8 0.2 0.36 9.5 0.2 2.1 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 KOS16799.1 - 0.052 12.8 0.3 6.3 5.9 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS16799.1 - 0.64 9.5 7.1 2.3 7.7 0.5 3.1 2 1 0 2 2 2 0 FAD dependent oxidoreductase Tyr-DNA_phospho PF06087.12 KOS16800.1 - 1.2e-13 50.8 0.0 1.1e-07 31.1 0.0 2.0 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase MMM1 PF10296.9 KOS16801.1 - 7.2e-121 403.3 0.0 2.7e-119 398.1 0.0 2.0 1 1 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 MBOAT PF03062.19 KOS16802.1 - 0.00042 19.8 0.1 0.00042 19.8 0.1 1.5 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family DUF3961 PF13106.6 KOS16802.1 - 0.058 13.0 1.2 0.12 12.0 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) FTSW_RODA_SPOVE PF01098.19 KOS16802.1 - 0.069 12.1 0.3 0.091 11.7 0.3 1.1 1 0 0 1 1 1 0 Cell cycle protein Creatinase_N PF01321.18 KOS16803.1 - 7.9e-16 58.9 0.0 1e-15 58.6 0.0 1.1 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain Creatinase_N_2 PF16189.5 KOS16803.1 - 1.6e-06 28.3 0.1 2.6e-05 24.4 0.0 2.3 2 1 0 2 2 2 1 Creatinase/Prolidase N-terminal domain DUF4588 PF15251.6 KOS16804.1 - 0.032 14.0 0.4 0.037 13.8 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4588) Bac_small_YrzI PF09501.10 KOS16804.1 - 7.3 6.8 10.4 5.8 7.1 1.9 3.2 3 0 0 3 3 3 0 Probable sporulation protein (Bac_small_yrzI) CDP-OH_P_transf PF01066.21 KOS16805.1 - 3.8e-14 53.2 0.6 3.8e-14 53.2 0.6 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Activator_LAG-3 PF11498.8 KOS16805.1 - 0.078 11.9 6.9 0.096 11.6 6.9 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF3270 PF11674.8 KOS16805.1 - 0.089 13.0 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) GIDA_assoc PF13932.6 KOS16806.1 - 2.1e-67 227.4 0.0 3e-67 226.9 0.0 1.2 1 0 0 1 1 1 1 GidA associated domain GIDA PF01134.22 KOS16806.1 - 4.1e-65 220.4 0.0 5.3e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Sec1 PF00995.23 KOS16807.1 - 5.3e-108 362.7 2.0 6.4e-108 362.5 2.0 1.0 1 0 0 1 1 1 1 Sec1 family LegC3_N PF18654.1 KOS16807.1 - 0.0087 15.3 0.3 0.019 14.2 0.3 1.6 1 0 0 1 1 1 1 LegC3 N-terminal coiled-coil domain CdiI_2 PF18593.1 KOS16807.1 - 0.1 13.2 0.2 1.1 10.0 0.0 2.6 3 0 0 3 3 3 0 CdiI immunity protein Methyltransf_23 PF13489.6 KOS16808.1 - 4.2e-16 59.2 0.0 6.4e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS16808.1 - 7.3e-09 36.2 0.0 2.6e-08 34.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS16808.1 - 7.7e-08 33.0 0.0 7e-07 29.9 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KOS16808.1 - 1.6e-05 25.1 0.0 2.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 KOS16808.1 - 0.00053 19.8 0.0 0.0096 15.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS16808.1 - 0.0033 18.0 0.0 0.0068 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS16808.1 - 0.024 14.0 0.0 0.22 10.8 0.0 2.2 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 KOS16808.1 - 0.034 13.6 0.0 0.059 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase Apt1 PF10351.9 KOS16809.1 - 1.5e-193 644.0 0.9 1.5e-193 644.0 0.9 2.5 3 0 0 3 3 3 1 Golgi-body localisation protein domain Fmp27 PF10344.9 KOS16809.1 - 5e-190 633.7 0.0 8.2e-190 633.0 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 KOS16809.1 - 3.9e-180 599.8 0.3 3.9e-180 599.8 0.3 2.2 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 KOS16809.1 - 1.7e-54 184.0 0.2 3.8e-54 182.8 0.2 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_GFWDK PF10347.9 KOS16809.1 - 6.8e-54 182.2 0.0 1.3e-53 181.2 0.0 1.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Fmp27_SW PF10305.9 KOS16809.1 - 2.5e-32 111.6 0.0 1.4e-31 109.2 0.0 2.5 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Glyco_hydro_17 PF00332.18 KOS16810.1 - 1.9e-08 34.3 0.5 2.9e-08 33.7 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 ATP-synt_10 PF05176.14 KOS16811.1 - 1.1e-75 254.2 0.0 1.4e-75 253.8 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein V-SNARE_C PF12352.8 KOS16812.1 - 7e-13 48.7 0.1 7e-13 48.7 0.1 3.0 3 0 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus LXG PF04740.12 KOS16812.1 - 0.031 14.0 4.7 0.22 11.2 0.2 2.9 1 1 2 3 3 3 0 LXG domain of WXG superfamily Not3 PF04065.15 KOS16812.1 - 0.15 11.5 5.3 0.86 9.0 2.7 2.2 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Spc7 PF08317.11 KOS16812.1 - 0.15 10.9 8.9 0.05 12.5 6.2 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 KOS16812.1 - 0.33 11.0 2.2 20 5.2 0.0 2.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF4164 PF13747.6 KOS16812.1 - 0.37 11.1 11.0 0.51 10.7 9.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4164) MetOD2 PF18548.1 KOS16812.1 - 0.51 10.5 4.3 5.7 7.1 2.2 3.0 2 1 1 3 3 3 0 Metanogen output domain 2 Laminin_II PF06009.12 KOS16812.1 - 0.59 10.1 9.4 5.4 7.0 6.6 2.8 2 1 0 2 2 2 0 Laminin Domain II Atg14 PF10186.9 KOS16812.1 - 0.66 9.0 11.1 1.1 8.3 10.9 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Snapin_Pallidin PF14712.6 KOS16812.1 - 1.8 9.0 11.1 0.32 11.4 6.8 2.0 3 0 0 3 3 3 0 Snapin/Pallidin Csm1_N PF18504.1 KOS16812.1 - 2.5 8.5 9.5 3.6 8.0 1.8 3.2 2 1 1 3 3 3 0 Csm1 N-terminal domain Exonuc_VII_L PF02601.15 KOS16812.1 - 3.3 7.2 12.0 5.2 6.6 11.8 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Fez1 PF06818.15 KOS16812.1 - 5.3 7.4 9.6 11 6.4 9.7 1.6 1 1 0 1 1 1 0 Fez1 Ribosomal_L29 PF00831.23 KOS16813.1 - 1e-16 60.6 0.5 1e-16 60.6 0.5 2.2 1 1 1 2 2 2 1 Ribosomal L29 protein DEAD PF00270.29 KOS16815.1 - 8.3e-51 172.2 0.0 4e-49 166.7 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS16815.1 - 1.3e-27 96.3 0.0 4.5e-27 94.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS16815.1 - 0.0034 17.4 0.0 0.017 15.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Ribosomal_60s PF00428.19 KOS16815.1 - 0.0069 16.9 12.7 0.0069 16.9 12.7 6.7 6 1 1 7 7 7 1 60s Acidic ribosomal protein HCNGP PF07818.13 KOS16816.1 - 7.3e-25 87.4 0.0 9e-25 87.2 0.0 1.2 1 0 0 1 1 1 1 HCNGP-like protein DUF3712 PF12505.8 KOS16817.1 - 6.8e-27 94.2 0.8 6.8e-27 94.2 0.8 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF3712) WBP-1 PF11669.8 KOS16817.1 - 0.0035 18.0 0.1 0.0066 17.1 0.1 1.4 1 0 0 1 1 1 1 WW domain-binding protein 1 LEA_2 PF03168.13 KOS16817.1 - 0.038 14.5 2.5 1.5 9.4 0.3 3.2 2 2 1 3 3 3 0 Late embryogenesis abundant protein Baculo_F PF12259.8 KOS16817.1 - 0.1 11.1 0.2 0.13 10.7 0.2 1.1 1 0 0 1 1 1 0 Baculovirus F protein UPF0370 PF13980.6 KOS16817.1 - 0.11 12.5 1.7 0.23 11.5 1.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) Ferlin_C PF16165.5 KOS16817.1 - 0.14 12.1 0.4 0.23 11.4 0.4 1.3 1 0 0 1 1 1 0 Ferlin C-terminus DUF929 PF06053.11 KOS16817.1 - 0.19 11.0 2.3 0.31 10.3 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) DUF4307 PF14155.6 KOS16817.1 - 0.2 11.5 0.5 0.41 10.5 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) Baculo_11_kDa PF06143.11 KOS16817.1 - 0.29 10.7 3.5 0.61 9.7 3.5 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family FMN_dh PF01070.18 KOS16818.1 - 7.3e-111 370.6 0.8 8.6e-111 370.3 0.8 1.0 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 KOS16818.1 - 2.6e-21 75.6 0.0 5.1e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 KOS16818.1 - 3.8e-06 26.3 0.1 6.2e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 KOS16818.1 - 8.9e-05 21.6 0.2 0.00051 19.1 0.0 2.0 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain His_biosynth PF00977.21 KOS16818.1 - 0.081 12.4 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Histidine biosynthesis protein HSCB_C PF07743.13 KOS16819.1 - 4.1e-14 52.8 2.6 4.1e-14 52.8 2.6 1.5 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 KOS16819.1 - 0.0014 18.7 0.3 0.0029 17.7 0.3 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1542 PF07564.11 KOS16819.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1542) Arrestin_N PF00339.29 KOS16820.1 - 5.9e-17 62.1 0.0 1e-15 58.1 0.0 2.6 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 KOS16820.1 - 2e-05 25.1 0.0 0.00018 22.0 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Sugar_tr PF00083.24 KOS16821.1 - 1.1e-88 298.0 22.3 1.5e-88 297.7 22.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS16821.1 - 6e-22 78.0 34.6 6.5e-19 68.1 27.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS16821.1 - 9.3e-06 24.7 0.3 0.0012 17.7 1.5 2.7 2 1 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 KOS16821.1 - 0.00033 19.2 0.9 0.00033 19.2 0.9 2.0 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) DUF1772 PF08592.11 KOS16822.1 - 5.3e-07 30.0 3.8 1.2e-06 28.9 3.8 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF1772) Sld5 PF05916.11 KOS16823.1 - 4.1e-12 46.5 0.0 6.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Proteasom_Rpn13 PF04683.13 KOS16824.1 - 1.6e-23 83.0 0.0 3.5e-23 81.9 0.0 1.6 2 0 0 2 2 2 1 Proteasome complex subunit Rpn13 ubiquitin receptor RPN13_C PF16550.5 KOS16824.1 - 2.6e-10 40.4 3.7 1.7e-08 34.6 3.7 2.3 1 1 0 1 1 1 1 UCH-binding domain L27_2 PF09045.10 KOS16824.1 - 0.0012 18.8 0.1 0.0025 17.8 0.1 1.5 1 0 0 1 1 1 1 L27_2 Rootletin PF15035.6 KOS16825.1 - 0.016 15.3 3.1 0.016 15.3 3.1 1.8 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Secretin_N_2 PF07655.13 KOS16825.1 - 0.059 13.9 0.0 0.22 12.1 0.0 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain DUF2935 PF11155.8 KOS16825.1 - 0.18 12.1 0.2 0.43 10.9 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) TAFII55_N PF04658.13 KOS16826.1 - 3.8e-50 169.7 0.0 2.3e-49 167.2 0.0 2.1 2 0 0 2 2 2 1 TAFII55 protein conserved region Mucin PF01456.17 KOS16826.1 - 0.54 10.3 27.0 1.2 9.1 27.0 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein NOA36 PF06524.12 KOS16826.1 - 0.85 8.9 54.1 0.69 9.2 24.3 3.4 3 0 0 3 3 3 0 NOA36 protein PPP4R2 PF09184.11 KOS16826.1 - 0.95 9.0 35.3 0.79 9.3 1.2 3.3 3 0 0 3 3 3 0 PPP4R2 Mpp10 PF04006.12 KOS16826.1 - 1.5 7.2 38.9 0.33 9.3 33.9 2.0 2 0 0 2 2 2 0 Mpp10 protein p450 PF00067.22 KOS16827.1 - 8.9e-73 245.6 0.0 1e-72 245.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3074 PF11274.8 KOS16828.1 - 5.7e-42 143.8 0.8 7.4e-42 143.4 0.4 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) Stk19 PF10494.9 KOS16829.1 - 2.2e-46 158.5 0.0 2.8e-46 158.2 0.0 1.1 1 0 0 1 1 1 1 Serine-threonine protein kinase 19 Sulfate_transp PF00916.20 KOS16830.1 - 8.7e-48 163.0 12.3 8e-25 87.4 0.4 2.3 2 0 0 2 2 2 2 Sulfate permease family cNMP_binding PF00027.29 KOS16830.1 - 1.3e-15 57.2 0.0 2.6e-15 56.3 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain STAS PF01740.21 KOS16830.1 - 3.1e-11 43.0 0.0 5.4e-11 42.2 0.0 1.4 1 0 0 1 1 1 1 STAS domain GED PF02212.18 KOS16830.1 - 0.087 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Dynamin GTPase effector domain HCV_NS5a_C PF12941.7 KOS16831.1 - 0.076 12.8 0.5 0.14 12.0 0.5 1.3 1 0 0 1 1 1 0 HCV NS5a protein C-terminal region Kinesin PF00225.23 KOS16832.1 - 1.1e-79 267.8 0.5 1.4e-78 264.1 0.1 2.1 1 1 1 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOS16832.1 - 1.1e-13 51.3 0.0 5.6e-10 39.3 0.0 2.5 1 1 1 2 2 2 2 Microtubule binding PKcGMP_CC PF16808.5 KOS16832.1 - 0.028 14.3 0.3 0.028 14.3 0.3 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 KOS16832.1 - 0.45 9.8 11.9 0.4 10.0 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MAGI_u1 PF16663.5 KOS16832.1 - 1.6 8.8 5.7 0.33 11.1 1.0 2.3 2 0 0 2 2 2 0 Unstructured region on MAGI DUF724 PF05266.14 KOS16832.1 - 3.9 7.3 6.3 13 5.5 2.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF724) JAB PF01398.21 KOS16833.1 - 1e-31 109.4 0.0 1.4e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CSN5_C PF18323.1 KOS16833.1 - 9e-23 81.0 0.0 1.8e-22 80.1 0.0 1.5 1 0 0 1 1 1 1 Cop9 signalosome subunit 5 C-terminal domain Prok-JAB PF14464.6 KOS16833.1 - 6.6e-06 25.9 0.0 1.2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 KOS16833.1 - 0.067 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) FoP_duplication PF13865.6 KOS16833.1 - 0.18 12.4 3.2 0.42 11.2 3.2 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 ATP_sub_h PF10775.9 KOS16834.1 - 1.3e-23 82.7 0.2 2.2e-23 82.0 0.2 1.4 1 0 0 1 1 1 1 ATP synthase complex subunit h LTXXQ PF07813.12 KOS16836.1 - 0.067 13.9 4.8 0.32 11.7 0.0 2.5 2 0 0 2 2 2 0 LTXXQ motif family protein zf-C2H2_4 PF13894.6 KOS16836.1 - 4.8 8.3 10.6 3.1 8.9 2.8 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Cwf_Cwc_15 PF04889.12 KOS16838.1 - 0.0024 17.7 5.0 0.0046 16.7 5.0 1.4 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein KI67R PF08065.12 KOS16838.1 - 0.06 13.9 0.2 0.19 12.3 0.2 1.8 1 0 0 1 1 1 0 KI67R (NUC007) repeat PBP1_TM PF14812.6 KOS16838.1 - 3.6 8.0 8.3 8.6 6.8 8.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF726 PF05277.12 KOS16839.1 - 1.5 7.7 5.2 2.2 7.1 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Annexin PF00191.20 KOS16840.1 - 3.9e-65 215.8 1.1 1.5e-17 63.4 0.0 4.1 4 0 0 4 4 4 4 Annexin DUF3574 PF12098.8 KOS16840.1 - 0.056 13.2 0.2 9.9 6.0 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3574) Peptidase_C13 PF01650.18 KOS16840.1 - 0.075 12.5 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase C13 family Stealth_CR3 PF17102.5 KOS16840.1 - 0.41 10.6 2.0 12 5.9 0.3 2.7 3 0 0 3 3 3 0 Stealth protein CR3, conserved region 3 Abhydrolase_1 PF00561.20 KOS16844.1 - 7e-15 55.4 0.2 1.5e-14 54.3 0.0 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS16844.1 - 1.1e-06 29.4 0.0 2.1e-06 28.5 0.0 1.6 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS16844.1 - 2.3e-06 27.1 0.0 8.6e-06 25.2 0.0 1.8 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 KOS16844.1 - 0.0049 15.8 0.0 0.0077 15.2 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOS16844.1 - 0.019 14.0 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase PGAP1 PF07819.13 KOS16844.1 - 0.072 12.8 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein DUF1057 PF06342.12 KOS16844.1 - 0.19 10.7 0.0 0.33 10.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) Polysacc_synt_C PF14667.6 KOS16845.1 - 0.042 13.9 7.2 0.059 13.4 0.8 2.2 1 1 1 2 2 2 0 Polysaccharide biosynthesis C-terminal domain SUZ PF12752.7 KOS16847.1 - 0.00031 21.4 4.9 0.00031 21.4 4.9 5.0 3 1 0 3 3 3 2 SUZ domain RRM_1 PF00076.22 KOS16848.1 - 1.9e-08 34.0 0.0 5.4e-08 32.6 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS16848.1 - 1.1e-06 28.3 0.0 1.5e-06 27.8 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOS16848.1 - 0.0005 20.1 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 Limkain b1 RRM_occluded PF16842.5 KOS16848.1 - 0.14 12.0 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Occluded RNA-recognition motif Autophagy_act_C PF03987.15 KOS16849.1 - 4.9e-12 46.2 0.0 9.3e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Ribonuc_L-PSP PF01042.21 KOS16850.1 - 1.1e-36 125.5 0.0 1.3e-36 125.2 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP DAHP_synth_1 PF00793.20 KOS16851.1 - 5.9e-97 323.8 0.0 7.6e-97 323.5 0.0 1.1 1 0 0 1 1 1 1 DAHP synthetase I family Pro_isomerase PF00160.21 KOS16852.1 - 1.6e-51 174.7 0.6 2.9e-51 173.9 0.1 1.7 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD WD40 PF00400.32 KOS16852.1 - 8.8e-13 48.5 0.2 0.00025 21.8 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS16852.1 - 6.6e-06 26.3 0.0 0.0092 16.3 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS16852.1 - 0.0015 17.6 0.5 0.21 10.5 0.1 3.3 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Fe_hyd_lg_C PF02906.14 KOS16853.1 - 3.3e-46 157.9 0.0 7.8e-46 156.7 0.0 1.7 1 1 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Chorion_3 PF05387.11 KOS16853.1 - 0.14 11.8 2.6 0.3 10.7 2.6 1.5 1 0 0 1 1 1 0 Chorion family 3 Myc_N PF01056.18 KOS16853.1 - 0.21 11.5 1.2 0.4 10.5 1.2 1.4 1 0 0 1 1 1 0 Myc amino-terminal region zf-H2C2_2 PF13465.6 KOS16854.1 - 2.7e-06 27.5 11.0 5.4e-06 26.6 1.3 3.3 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2 PF00096.26 KOS16854.1 - 9.9e-06 25.7 0.5 9.9e-06 25.7 0.5 3.2 2 1 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KOS16854.1 - 5.9e-05 23.0 4.9 0.011 15.7 0.0 2.9 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 KOS16854.1 - 0.00014 22.5 4.9 0.25 12.0 0.0 2.8 2 1 1 3 3 3 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 KOS16854.1 - 0.00022 21.8 4.5 0.004 17.9 0.4 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KOS16854.1 - 0.1 12.4 1.1 0.58 10.0 0.1 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KOS16854.1 - 0.21 11.9 1.5 2.6 8.4 0.3 2.6 2 1 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 KOS16854.1 - 0.23 11.3 2.8 0.64 9.8 0.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Nop14 PF04147.12 KOS16855.1 - 0.35 9.0 23.2 0.45 8.7 23.2 1.1 1 0 0 1 1 1 0 Nop14-like family COPI_C PF06957.11 KOS16855.1 - 0.52 9.0 16.9 0.61 8.8 16.9 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus NOA36 PF06524.12 KOS16855.1 - 0.77 9.0 24.5 1.1 8.5 24.5 1.4 1 0 0 1 1 1 0 NOA36 protein CNDH2_C PF16858.5 KOS16855.1 - 1.1 9.1 10.6 1.2 8.9 10.6 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2457 PF10446.9 KOS16855.1 - 2 7.5 29.6 2.3 7.2 29.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 KOS16855.1 - 2 7.8 22.9 2.3 7.5 22.9 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 KOS16855.1 - 2.9 7.2 19.4 3.4 6.9 19.4 1.2 1 0 0 1 1 1 0 BUD22 SGT1 PF07093.11 KOS16855.1 - 4.1 5.7 12.2 4.4 5.6 12.2 1.1 1 0 0 1 1 1 0 SGT1 protein CobT PF06213.12 KOS16855.1 - 5.7 6.2 19.4 7.7 5.8 19.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 KOS16855.1 - 6.5 4.9 19.4 7.3 4.8 19.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SPX PF03105.19 KOS16856.1 - 8.7 6.1 9.2 12 5.7 9.2 1.2 1 0 0 1 1 1 0 SPX domain WD40 PF00400.32 KOS16857.1 - 6.3e-15 55.3 13.7 0.0029 18.4 0.1 6.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS16857.1 - 2.4e-06 27.7 0.0 0.32 11.3 0.0 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Gmad1 PF10647.9 KOS16857.1 - 0.057 13.2 2.5 0.25 11.0 0.1 2.8 2 2 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Isy1 PF06246.12 KOS16858.1 - 7.3e-88 294.4 0.0 8.9e-88 294.1 0.0 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DDOST_48kD PF03345.14 KOS16859.1 - 1.3e-156 521.7 0.0 1.5e-156 521.5 0.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta NADHdh_A3 PF14987.6 KOS16860.1 - 0.025 14.9 1.3 0.027 14.8 0.9 1.3 1 1 0 1 1 1 0 NADH dehydrogenase 1 alpha subcomplex subunit 3 Beach PF02138.18 KOS16861.1 - 8.8e-120 399.2 0.0 1.8e-119 398.2 0.0 1.6 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 KOS16861.1 - 1.8e-10 40.8 0.0 4.8e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 KOS16861.1 - 3e-10 40.5 0.1 8.1e-10 39.0 0.1 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 KOS16861.1 - 0.00093 20.0 5.1 0.93 10.5 0.0 4.9 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF4800 PF16057.5 KOS16861.1 - 0.026 13.8 0.5 0.1 11.9 0.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4800) DUF4704 PF15787.5 KOS16861.1 - 0.098 11.9 0.0 0.44 9.7 0.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4704) Peptidase_S8 PF00082.22 KOS16862.1 - 1.8e-32 112.8 10.1 2.9e-32 112.1 10.1 1.4 1 0 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOS16862.1 - 3.3e-21 75.7 0.3 7.6e-21 74.6 0.3 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 PAF-AH_p_II PF03403.13 KOS16863.1 - 6.2e-25 87.5 0.0 1.6e-23 82.9 0.0 2.8 1 1 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KOS16863.1 - 0.0092 14.9 0.0 0.23 10.3 0.0 2.1 2 0 0 2 2 2 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOS16863.1 - 0.1 11.6 0.0 0.22 10.5 0.0 1.5 2 0 0 2 2 2 0 Chlorophyllase CALM_bind PF16025.5 KOS16864.1 - 0.68 10.4 5.5 1.3 9.6 5.5 1.4 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding COX17 PF05051.13 KOS16865.1 - 9.8e-21 73.9 5.9 1.2e-20 73.6 5.9 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) SLC35F PF06027.12 KOS16866.1 - 6.3e-97 324.7 12.1 8.2e-97 324.3 12.1 1.1 1 0 0 1 1 1 1 Solute carrier family 35 CRT-like PF08627.10 KOS16866.1 - 2.9e-08 33.1 0.0 6.1e-08 32.0 0.0 1.6 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 KOS16866.1 - 7.8e-06 26.1 30.6 0.0068 16.6 10.0 2.2 2 0 0 2 2 2 2 EamA-like transporter family FUSC-like PF12805.7 KOS16866.1 - 0.64 9.1 3.8 2.1 7.3 0.2 2.6 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS CH PF00307.31 KOS16867.1 - 0.082 13.1 0.0 0.32 11.2 0.0 1.9 1 1 1 2 2 2 0 Calponin homology (CH) domain Cpn60_TCP1 PF00118.24 KOS16868.1 - 1.7e-148 495.3 14.0 2e-148 495.1 14.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mt_ATP-synt_B PF05405.14 KOS16869.1 - 0.029 14.0 5.3 0.054 13.1 5.3 1.5 1 1 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Ubiquitin_4 PF18036.1 KOS16869.1 - 0.093 12.8 1.1 0.16 12.0 0.9 1.4 1 1 0 1 1 1 0 Ubiquitin-like domain Noelin-1 PF12308.8 KOS16869.1 - 0.11 12.5 4.2 0.29 11.1 1.3 2.0 1 1 1 2 2 2 0 Neurogenesis glycoprotein FUSC PF04632.12 KOS16869.1 - 1 7.8 10.8 1.2 7.6 10.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF2203 PF09969.9 KOS16869.1 - 1.8 9.3 5.7 3.1 8.5 5.7 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) AAA PF00004.29 KOS16871.1 - 3.3e-40 137.6 0.0 5.5e-40 136.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS16871.1 - 7.3e-07 28.9 0.0 1.7e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KOS16871.1 - 9.3e-05 22.4 0.1 0.00049 20.1 0.0 2.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS16871.1 - 0.00014 22.1 0.0 0.0056 17.0 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 KOS16871.1 - 0.00066 20.1 0.1 0.013 15.9 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOS16871.1 - 0.00073 19.7 0.0 0.0018 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 KOS16871.1 - 0.0021 17.3 0.0 0.0036 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOS16871.1 - 0.0085 15.9 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 KOS16871.1 - 0.028 14.7 0.0 0.063 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOS16871.1 - 0.037 14.4 0.0 0.15 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA helicase AAA_3 PF07726.11 KOS16871.1 - 0.048 13.5 0.0 0.16 11.9 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOS16871.1 - 0.05 13.1 0.0 0.14 11.7 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KOS16871.1 - 0.051 13.7 0.0 0.094 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOS16871.1 - 0.084 12.9 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOS16871.1 - 0.085 12.6 0.1 0.6 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOS16871.1 - 0.09 12.5 0.1 0.25 11.1 0.1 1.9 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOS16871.1 - 0.14 12.7 0.0 0.47 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sortilin-Vps10 PF15902.5 KOS16873.1 - 6.3e-287 951.4 10.6 1.9e-146 488.4 4.1 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 KOS16873.1 - 1e-91 305.8 25.0 1.2e-46 159.2 9.3 2.6 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR_2 PF13088.6 KOS16873.1 - 7.2e-08 32.1 1.4 0.43 9.8 0.0 5.4 4 2 2 6 6 6 3 BNR repeat-like domain BNR PF02012.20 KOS16873.1 - 7e-07 28.3 47.2 1 9.6 0.3 12.0 12 0 0 12 12 12 4 BNR/Asp-box repeat PSII_BNR PF14870.6 KOS16873.1 - 0.005 16.1 2.3 1.7 7.8 0.0 4.1 4 1 1 5 5 5 1 Photosynthesis system II assembly factor YCF48 CHB_HEX_C PF03174.13 KOS16873.1 - 0.021 14.8 2.6 0.58 10.2 0.2 4.2 5 0 0 5 5 5 0 Chitobiase/beta-hexosaminidase C-terminal domain DUF2561 PF10812.8 KOS16873.1 - 0.049 13.7 0.0 0.089 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2561) CSS-motif PF12792.7 KOS16873.1 - 0.13 11.7 0.1 0.26 10.7 0.1 1.4 1 0 0 1 1 1 0 CSS motif domain associated with EAL Shal-type PF11601.8 KOS16873.1 - 0.19 11.3 2.8 0.43 10.1 2.8 1.5 1 0 0 1 1 1 0 Shal-type voltage-gated potassium channels, N-terminal SARAF PF06682.12 KOS16874.1 - 0.0038 16.9 0.7 1.4 8.5 0.9 2.3 2 0 0 2 2 2 2 SOCE-associated regulatory factor of calcium homoeostasis AJAP1_PANP_C PF15298.6 KOS16874.1 - 0.23 11.7 2.2 0.38 10.9 0.3 2.2 2 0 0 2 2 2 0 AJAP1/PANP C-terminus HLH PF00010.26 KOS16875.1 - 1e-09 38.2 0.0 2.2e-09 37.2 0.0 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain bZIP_1 PF00170.21 KOS16875.1 - 0.0054 16.8 1.0 0.013 15.5 1.0 1.6 1 0 0 1 1 1 1 bZIP transcription factor Herpes_UL74 PF07982.12 KOS16875.1 - 0.056 12.4 5.6 0.094 11.7 5.6 1.3 1 0 0 1 1 1 0 Herpes UL74 glycoproteins ZapB PF06005.12 KOS16875.1 - 0.18 12.3 4.8 0.37 11.3 1.4 2.3 2 0 0 2 2 2 0 Cell division protein ZapB APG6_N PF17675.1 KOS16875.1 - 1.9 9.0 8.4 0.066 13.7 1.3 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region Cnn_1N PF07989.11 KOS16875.1 - 3.1 8.0 6.1 0.26 11.5 0.7 1.9 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF3439 PF11921.8 KOS16875.1 - 6.6 6.7 14.3 2.7 8.0 8.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Pcc1 PF09341.10 KOS16876.1 - 1e-30 105.7 0.0 1.2e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Pcc1 DSPn PF14671.6 KOS16877.1 - 1.5e-40 138.9 0.0 1.8e-38 132.2 0.0 2.5 2 0 0 2 2 2 2 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 KOS16877.1 - 4.1e-17 62.2 0.0 9.7e-17 61.0 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOS16877.1 - 1.5e-05 24.7 0.0 2.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Pyrophosphatase PF00719.19 KOS16878.1 - 1.8e-58 196.9 0.1 2.7e-58 196.3 0.1 1.3 1 0 0 1 1 1 1 Inorganic pyrophosphatase TAP_C PF03943.13 KOS16879.1 - 3.1e-18 65.1 0.3 7.9e-18 63.8 0.1 1.8 2 0 0 2 2 2 1 TAP C-terminal domain NTF2 PF02136.20 KOS16879.1 - 2.7e-05 24.7 0.0 0.00029 21.4 0.0 2.3 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_9 PF18444.1 KOS16879.1 - 0.00045 20.0 0.0 0.0028 17.5 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif LRR_4 PF12799.7 KOS16879.1 - 0.00054 20.3 0.3 0.0025 18.2 0.2 2.2 1 1 0 1 1 1 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS16879.1 - 0.02 14.7 0.1 0.11 12.3 0.0 2.4 2 0 0 2 2 2 0 Leucine rich repeat Sec20 PF03908.13 KOS16880.1 - 8.2e-14 51.3 0.1 5.9e-13 48.6 0.1 2.1 2 0 0 2 2 2 1 Sec20 DUF5549 PF17703.1 KOS16880.1 - 0.028 14.1 1.0 0.065 12.9 1.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5549) MRP_L53 PF10780.9 KOS16881.1 - 7.1e-21 74.1 0.2 9.8e-21 73.7 0.2 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Ecotin PF03974.13 KOS16881.1 - 0.083 12.9 0.0 0.1 12.6 0.0 1.1 1 0 0 1 1 1 0 Ecotin DUF2442 PF10387.9 KOS16881.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) Ribosomal_L2_C PF03947.18 KOS16881.1 - 0.21 11.8 0.0 0.27 11.4 0.0 1.1 1 0 0 1 1 1 0 Ribosomal Proteins L2, C-terminal domain TRAPP PF04051.16 KOS16882.1 - 5.7e-45 152.6 0.0 1e-44 151.8 0.0 1.4 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component DUF3235 PF11574.8 KOS16882.1 - 0.15 12.9 4.0 9 7.2 4.0 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3235) PINIT PF14324.6 KOS16883.1 - 1.6e-35 122.6 0.0 3.5e-35 121.5 0.0 1.5 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 KOS16883.1 - 1.7e-21 75.7 6.6 3.6e-21 74.6 6.6 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KOS16883.1 - 5.5e-06 26.1 1.7 1.3e-05 24.9 1.7 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 KOS16883.1 - 0.12 12.6 6.3 0.25 11.6 6.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING PHD PF00628.29 KOS16883.1 - 0.45 10.4 3.2 1 9.3 3.2 1.6 1 0 0 1 1 1 0 PHD-finger Phosphodiest PF01663.22 KOS16884.1 - 8.1e-13 48.7 0.3 1.2e-12 48.1 0.3 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOS16884.1 - 4.1e-05 23.1 0.0 6.3e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 KOS16884.1 - 0.0074 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DUF373 PF04123.13 KOS16884.1 - 5.5 6.3 9.1 3.5 7.0 7.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF373) GPI-anchored PF10342.9 KOS16885.1 - 7.8e-09 36.2 0.1 7.8e-09 36.2 0.1 3.1 2 1 0 2 2 2 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family SOG2 PF10428.9 KOS16886.1 - 0.096 11.9 3.1 0.12 11.5 3.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3605 PF12239.8 KOS16887.1 - 2.3e-54 183.9 0.0 2.7e-54 183.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) UDPGP PF01704.18 KOS16888.1 - 7.3e-192 637.5 0.0 8.4e-192 637.3 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Leo1 PF04004.13 KOS16889.1 - 9.2e-36 123.2 0.0 1.9e-35 122.1 0.0 1.6 1 0 0 1 1 1 1 Leo1-like protein Mob1_phocein PF03637.17 KOS16890.1 - 7.8e-42 143.2 0.1 1.1e-41 142.7 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family CAP59_mtransfer PF11735.8 KOS16891.1 - 2.8e-69 233.5 0.0 3.7e-69 233.1 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 DUF3336 PF11815.8 KOS16892.1 - 1.5e-33 115.4 0.0 1.1e-32 112.6 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOS16892.1 - 1.1e-12 48.5 1.1 1.3e-11 45.1 0.2 2.3 2 0 0 2 2 2 1 Patatin-like phospholipase MEDS PF14417.6 KOS16892.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.5 1 0 0 1 1 1 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain 7tm_2 PF00002.24 KOS16893.1 - 1.5e-06 27.7 2.4 2.3e-06 27.1 2.4 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) FolB PF02152.18 KOS16894.1 - 9.3e-15 55.1 0.0 2.3e-09 37.8 0.0 3.9 2 2 0 2 2 2 2 Dihydroneopterin aldolase Questin_oxidase PF14027.6 KOS16895.1 - 1.5e-87 294.4 0.2 1.7e-87 294.1 0.2 1.0 1 0 0 1 1 1 1 Questin oxidase-like HECT_2 PF09814.9 KOS16896.1 - 5.1e-82 275.7 0.0 6e-82 275.5 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding Lipase_GDSL_2 PF13472.6 KOS16897.1 - 1.3e-18 68.1 0.0 1.7e-18 67.6 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 KOS16897.1 - 7.5e-06 26.1 0.0 2.3e-05 24.5 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase DUF5412 PF17428.2 KOS16897.1 - 0.21 11.4 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Rad17 PF03215.15 KOS16898.1 - 3.5e-25 89.0 0.0 8e-25 87.8 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 KOS16898.1 - 0.00034 21.0 0.1 0.00034 21.0 0.1 2.6 3 0 0 3 3 3 1 AAA ATPase domain TFIIA PF03153.13 KOS16898.1 - 0.0042 17.1 9.5 0.0042 17.1 9.5 3.2 3 0 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit AAA PF00004.29 KOS16898.1 - 0.011 16.2 0.0 0.04 14.4 0.0 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOS16898.1 - 0.013 15.6 2.1 0.019 15.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOS16898.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 KOS16898.1 - 0.016 15.5 0.0 0.05 13.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 KOS16898.1 - 0.021 13.9 0.0 0.043 12.9 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 KOS16898.1 - 0.028 14.4 0.0 0.072 13.0 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 KOS16898.1 - 0.08 13.5 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOS16898.1 - 0.083 13.1 0.0 0.083 13.1 0.0 2.2 2 0 0 2 2 1 0 AAA domain dNK PF01712.19 KOS16898.1 - 0.17 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase RR_TM4-6 PF06459.12 KOS16898.1 - 0.19 11.5 2.7 0.6 9.9 2.7 1.8 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4770 PF15994.5 KOS16898.1 - 0.3 11.3 3.0 0.74 10.0 3.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) ABC_tran PF00005.27 KOS16898.1 - 1.7 9.2 4.7 3.4 8.2 0.0 2.6 2 0 0 2 2 2 0 ABC transporter EPL1 PF10513.9 KOS16898.1 - 5.4 7.4 8.5 2.5 8.5 4.6 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Zip PF02535.22 KOS16898.1 - 6.4 5.9 7.8 2 7.6 3.0 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4817 PF16087.5 KOS16899.1 - 0.0011 18.7 0.0 0.0024 17.6 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain (DUF4817) Lact_bio_phlase PF09508.10 KOS16899.1 - 0.16 10.3 1.4 0.25 9.7 1.4 1.2 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain Ppx-GppA PF02541.16 KOS16900.1 - 9.8e-24 84.3 0.0 1.7e-22 80.2 0.0 2.0 1 1 0 1 1 1 1 Ppx/GppA phosphatase family LRR_4 PF12799.7 KOS16901.1 - 6e-09 36.1 7.8 0.0007 19.9 0.1 4.3 5 0 0 5 5 5 2 Leucine Rich repeats (2 copies) Med25_SD1 PF11235.8 KOS16901.1 - 0.00016 22.1 0.4 0.00038 20.8 0.4 1.6 1 0 0 1 1 1 1 Mediator complex subunit 25 synapsin 1 LRR_8 PF13855.6 KOS16901.1 - 0.071 12.9 14.2 0.77 9.6 7.7 3.1 2 1 0 2 2 2 0 Leucine rich repeat zf-RING_11 PF17123.5 KOS16903.1 - 1.7e-13 50.0 6.2 3.5e-13 49.0 6.2 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 KOS16903.1 - 2.7e-07 30.8 9.7 5.1e-07 29.9 9.7 1.5 1 0 0 1 1 1 1 Ring finger domain FHA PF00498.26 KOS16903.1 - 9e-05 22.8 0.0 0.00028 21.2 0.0 1.8 1 1 0 1 1 1 1 FHA domain zf-C3HC4 PF00097.25 KOS16903.1 - 0.0044 16.9 9.3 0.0088 15.9 9.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 KOS16903.1 - 0.0057 16.5 4.1 0.012 15.5 4.1 1.6 1 0 0 1 1 1 1 PHD-finger zf-RING_5 PF14634.6 KOS16903.1 - 0.019 14.9 6.7 0.035 14.1 6.7 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOS16903.1 - 0.022 14.6 9.0 0.048 13.5 9.0 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.6 KOS16903.1 - 0.074 13.3 0.6 0.15 12.4 0.6 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain zf-RING_UBOX PF13445.6 KOS16903.1 - 0.087 12.9 9.0 0.2 11.7 9.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-rbx1 PF12678.7 KOS16903.1 - 0.13 12.5 8.6 0.44 10.9 8.6 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOS16903.1 - 0.22 11.6 1.6 0.47 10.5 1.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 KOS16903.1 - 3.5 7.9 7.8 9.6 6.5 7.8 1.8 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 KOS16903.1 - 5.1 6.8 6.6 13 5.5 6.6 1.6 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Peptidase_M16_C PF05193.21 KOS16904.1 - 3.1e-50 170.7 0.0 5.4e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOS16904.1 - 9.3e-40 136.0 0.0 7.1e-39 133.2 0.0 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) SOG2 PF10428.9 KOS16904.1 - 3.6 6.7 15.3 6.1 5.9 15.3 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 KOS16904.1 - 9.3 4.7 6.0 13 4.2 6.0 1.1 1 0 0 1 1 1 0 Macoilin family S1 PF00575.23 KOS16906.1 - 8.1e-86 282.4 36.8 8.4e-17 61.3 1.1 13.0 13 0 0 13 13 13 9 S1 RNA binding domain TPR_14 PF13428.6 KOS16906.1 - 7.7e-06 26.3 5.0 0.04 14.7 0.0 5.6 3 1 3 6 6 6 1 Tetratricopeptide repeat RNase_II_C_S1 PF18614.1 KOS16906.1 - 1e-05 25.4 4.7 5.3 7.1 0.0 7.0 7 0 0 7 7 7 2 RNase II-type exonuclease C-terminal S1 domain SDA1 PF05285.12 KOS16906.1 - 5.2e-05 22.8 29.3 5.2e-05 22.8 29.3 3.2 3 1 0 3 3 3 1 SDA1 TPR_19 PF14559.6 KOS16906.1 - 0.00014 22.3 0.3 0.45 11.1 0.1 3.6 3 1 1 4 4 4 3 Tetratricopeptide repeat S1_2 PF13509.6 KOS16906.1 - 0.00042 20.3 0.1 30 4.8 0.0 5.6 5 0 0 5 5 5 0 S1 domain Suf PF05843.14 KOS16906.1 - 0.0032 17.5 0.3 0.0032 17.5 0.3 3.7 3 1 1 4 4 4 2 Suppressor of forked protein (Suf) TPR_2 PF07719.17 KOS16906.1 - 0.18 12.0 0.3 1.3 9.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CusF_Ec PF11604.8 KOS16906.1 - 0.22 11.5 2.3 6.9 6.7 0.1 4.3 4 0 0 4 4 4 0 Copper binding periplasmic protein CusF Nop14 PF04147.12 KOS16906.1 - 2 6.5 51.7 0.044 12.0 36.9 2.5 2 0 0 2 2 2 0 Nop14-like family Fungal_trans PF04082.18 KOS16907.1 - 1.6e-09 37.2 0.0 2.2e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain RAP-1 PF03085.15 KOS16907.1 - 0.035 13.8 0.0 0.059 13.1 0.0 1.4 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MAP65_ASE1 PF03999.12 KOS16908.1 - 1.1e-75 255.6 14.7 1.4e-75 255.2 14.7 1.2 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) SKA2 PF16740.5 KOS16908.1 - 0.0033 17.2 0.3 0.44 10.4 0.1 3.5 3 0 0 3 3 3 1 Spindle and kinetochore-associated protein 2 Spectrin PF00435.21 KOS16908.1 - 0.52 10.8 13.0 0.24 11.9 2.6 4.2 5 1 0 5 5 5 0 Spectrin repeat Cep57_CLD_2 PF14197.6 KOS16908.1 - 6.6 6.9 17.7 0.88 9.7 0.5 5.6 4 2 1 5 5 5 0 Centrosome localisation domain of PPC89 EF-hand_4 PF12763.7 KOS16909.1 - 2.7e-05 24.0 0.0 4.1e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand PRIMA1 PF16101.5 KOS16909.1 - 0.036 14.1 3.7 0.074 13.1 3.7 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ketoacyl-synt PF00109.26 KOS16909.1 - 0.059 12.9 0.4 0.089 12.4 0.4 1.2 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain EF-hand_7 PF13499.6 KOS16909.1 - 0.23 12.0 0.0 0.38 11.2 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair DUF1180 PF06679.12 KOS16909.1 - 6.8 7.1 6.8 0.74 10.2 2.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) ATP-synt_ab PF00006.25 KOS16912.1 - 1.7e-72 243.6 0.0 2.4e-72 243.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 KOS16912.1 - 5.5e-48 162.5 0.3 1.2e-47 161.4 0.3 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 KOS16912.1 - 3.9e-15 56.1 2.8 9.2e-15 54.9 2.8 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Spt20 PF12090.8 KOS16912.1 - 4.4 6.8 9.7 7.3 6.1 9.7 1.3 1 0 0 1 1 1 0 Spt20 family Aminotran_5 PF00266.19 KOS16915.1 - 5.3e-33 114.5 0.0 1.3e-32 113.2 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V AAA_12 PF13087.6 KOS16916.1 - 3.7e-38 131.2 1.8 5.2e-38 130.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOS16916.1 - 5.9e-38 130.3 0.0 3e-13 50.4 0.0 4.3 4 0 0 4 4 4 3 ATPase family associated with various cellular activities (AAA) AAA_lid_6 PF17866.1 KOS16916.1 - 8.7e-14 51.5 13.7 1.3e-07 31.6 0.6 4.0 3 0 0 3 3 3 2 AAA lid domain AAA_30 PF13604.6 KOS16916.1 - 4e-13 49.5 0.5 0.058 13.1 0.0 4.9 4 1 0 4 4 4 4 AAA domain AAA_22 PF13401.6 KOS16916.1 - 2.4e-10 40.8 8.9 0.023 14.9 0.0 6.9 5 2 0 6 6 6 3 AAA domain Viral_helicase1 PF01443.18 KOS16916.1 - 1.1e-09 38.4 0.1 0.089 12.5 0.0 5.5 5 0 0 5 5 5 2 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 KOS16916.1 - 1.2e-08 35.5 0.7 2 8.8 0.0 5.0 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.14 KOS16916.1 - 2.2e-08 34.2 0.4 0.097 12.7 0.0 4.1 4 0 0 4 4 3 3 AAA domain (dynein-related subfamily) AAA_11 PF13086.6 KOS16916.1 - 3.5e-08 33.6 34.9 2e-07 31.1 0.1 6.6 6 1 0 6 6 5 2 AAA domain AAA_16 PF13191.6 KOS16916.1 - 2.3e-07 31.4 7.4 0.19 12.1 0.0 5.2 5 0 0 5 5 4 3 AAA ATPase domain AAA_33 PF13671.6 KOS16916.1 - 1.4e-06 28.6 0.6 0.45 10.7 0.0 4.0 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 KOS16916.1 - 1.9e-06 27.4 0.9 0.36 10.2 0.0 4.0 4 0 0 4 4 4 2 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KOS16916.1 - 1.4e-05 24.9 9.1 1.6 8.4 0.0 4.9 5 0 0 5 5 4 3 AAA domain RuvB_N PF05496.12 KOS16916.1 - 2.1e-05 24.4 0.1 2.7 7.7 0.0 3.7 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 KOS16916.1 - 0.0001 22.7 0.4 2.5 8.5 0.0 3.8 3 0 0 3 3 3 1 RNA helicase Torsin PF06309.11 KOS16916.1 - 0.00014 22.0 0.1 11 6.1 0.0 4.0 4 0 0 4 4 4 0 Torsin Sigma54_activat PF00158.26 KOS16916.1 - 0.001 18.8 0.4 13 5.4 0.0 4.3 5 0 0 5 5 5 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 KOS16916.1 - 0.0011 18.8 0.1 11 5.7 0.0 3.6 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_18 PF13238.6 KOS16916.1 - 0.0011 19.5 9.9 6.1 7.4 0.1 5.1 4 0 0 4 4 4 1 AAA domain AAA_7 PF12775.7 KOS16916.1 - 0.0012 18.4 0.3 5.2 6.5 0.0 3.4 3 0 0 3 3 3 1 P-loop containing dynein motor region Guanylate_cyc_2 PF09778.9 KOS16916.1 - 0.0055 16.1 0.0 0.92 8.8 0.0 2.9 3 0 0 3 3 3 1 Guanylylate cyclase NTPase_1 PF03266.15 KOS16916.1 - 0.037 13.9 1.0 55 3.6 0.1 3.9 3 0 0 3 3 3 0 NTPase AAA_29 PF13555.6 KOS16916.1 - 0.05 13.4 0.4 13 5.6 0.0 3.3 3 0 0 3 3 3 0 P-loop containing region of AAA domain ADK PF00406.22 KOS16916.1 - 0.088 12.9 4.3 86 3.2 0.0 5.2 5 0 0 5 5 5 0 Adenylate kinase UvrD_C_2 PF13538.6 KOS16916.1 - 0.15 11.9 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain SRP54 PF00448.22 KOS16916.1 - 0.25 10.9 1.6 8.3 6.0 0.0 3.4 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KOS16916.1 - 0.48 10.0 3.5 1e+02 2.4 0.1 4.9 6 0 0 6 6 5 0 AAA domain zf-NF-X1 PF01422.17 KOS16916.1 - 1.1 9.4 8.6 2.7 8.2 8.6 1.7 1 0 0 1 1 1 0 NF-X1 type zinc finger ABC_tran PF00005.27 KOS16916.1 - 1.3 9.6 9.4 47 4.5 0.1 4.7 4 0 0 4 4 4 0 ABC transporter Abhydrolase_1 PF00561.20 KOS16918.1 - 7.7e-48 163.4 0.0 1.2e-46 159.5 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 KOS16918.1 - 0.0059 16.3 0.1 0.0099 15.5 0.1 1.3 1 0 0 1 1 1 1 Putative esterase SR-25 PF10500.9 KOS16918.1 - 0.008 15.8 6.7 0.008 15.8 6.7 1.5 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF1275 PF06912.11 KOS16919.1 - 3.6e-43 147.7 13.6 4.2e-43 147.5 13.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) Phage_holin_3_6 PF07332.11 KOS16919.1 - 0.31 11.1 0.0 0.31 11.1 0.0 3.2 3 1 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1043 PF06295.12 KOS16921.1 - 0.37 10.8 2.3 1.1 9.3 2.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) ARGLU PF15346.6 KOS16921.1 - 1.2 9.0 8.5 2.1 8.2 8.5 1.3 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Peptidase_M6 PF05547.11 KOS16922.1 - 2.9e-08 32.5 0.1 0.00074 18.0 1.4 2.1 2 0 0 2 2 2 2 Immune inhibitor A peptidase M6 Ribophorin_I PF04597.14 KOS16923.1 - 8.3e-146 486.6 0.0 9.6e-146 486.4 0.0 1.0 1 0 0 1 1 1 1 Ribophorin I Pil1 PF13805.6 KOS16924.1 - 2.3e-106 355.1 2.0 3e-106 354.8 2.0 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 Ank_2 PF12796.7 KOS16925.1 - 0.00016 22.2 0.0 0.009 16.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Hexokinase_2 PF03727.16 KOS16926.1 - 8.4e-84 280.8 0.0 1.1e-83 280.4 0.0 1.1 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KOS16926.1 - 5.6e-71 238.6 0.0 1.6e-70 237.0 0.0 1.7 2 0 0 2 2 2 1 Hexokinase TPP_enzyme_N PF02776.18 KOS16926.1 - 0.14 11.8 0.0 0.35 10.5 0.0 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Vps16_N PF04841.13 KOS16927.1 - 2e-84 283.8 0.0 4.5e-84 282.6 0.0 1.6 2 0 0 2 2 2 1 Vps16, N-terminal region Vps16_C PF04840.12 KOS16927.1 - 2.8e-78 263.2 0.0 4.3e-78 262.6 0.0 1.2 1 0 0 1 1 1 1 Vps16, C-terminal region ANAPC4_WD40 PF12894.7 KOS16927.1 - 0.0043 17.3 0.0 0.11 12.8 0.0 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain VTC PF09359.10 KOS16928.1 - 4.4e-98 328.1 0.0 6.8e-98 327.4 0.0 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 KOS16928.1 - 1.2e-13 51.3 1.3 2.4e-13 50.3 1.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 KOS16928.1 - 1.2e-12 48.5 4.9 1.1e-05 25.5 0.0 4.1 3 1 1 4 4 4 2 SPX domain HTH_29 PF13551.6 KOS16928.1 - 0.0066 16.5 0.0 0.092 12.8 0.1 2.4 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.6 KOS16928.1 - 0.025 14.7 0.1 0.064 13.4 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.19 KOS16928.1 - 0.027 14.7 0.1 0.059 13.6 0.1 1.5 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain TrmB PF01978.19 KOS16928.1 - 0.038 13.9 0.1 0.12 12.2 0.1 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Exo_endo_phos PF03372.23 KOS16929.1 - 5.1e-17 62.2 0.8 8.1e-17 61.5 0.8 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family KH_1 PF00013.29 KOS16930.1 - 8.3e-43 144.1 6.6 6.3e-18 64.4 0.3 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOS16930.1 - 3.5e-13 49.2 3.1 0.0031 17.3 0.3 3.2 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOS16930.1 - 1.2e-06 28.3 1.7 0.27 11.1 0.0 3.3 3 0 0 3 3 3 2 KH domain MOEP19 PF16005.5 KOS16930.1 - 2e-05 24.5 0.0 0.0077 16.2 0.0 2.9 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 KOS16930.1 - 6.3e-05 23.0 7.9 0.3 11.2 0.2 3.4 3 0 0 3 3 3 3 NusA-like KH domain G-patch PF01585.23 KOS16931.1 - 3.8e-05 23.5 0.0 0.00011 22.0 0.0 1.9 1 0 0 1 1 1 1 G-patch domain TFIIF_alpha PF05793.12 KOS16931.1 - 0.88 8.1 80.5 1.4 7.4 80.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPL PF17800.1 KOS16932.1 - 1.5e-32 112.3 6.4 1.5e-32 112.3 6.4 3.5 2 2 0 2 2 2 1 Nucleoplasmin-like domain FKBP_C PF00254.28 KOS16932.1 - 1e-30 105.9 0.2 6.4e-30 103.3 0.0 2.4 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase DDHD PF02862.17 KOS16932.1 - 8.2 6.5 13.0 6.2 6.9 7.5 2.3 2 0 0 2 2 2 0 DDHD domain DUF1746 PF08508.10 KOS16933.1 - 1.9e-39 134.6 1.9 2.8e-39 134.0 1.9 1.3 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1746) REV PF00424.18 KOS16933.1 - 0.023 14.7 0.5 0.078 13.0 0.5 1.9 1 0 0 1 1 1 0 REV protein (anti-repression trans-activator protein) RTC PF01137.21 KOS16934.1 - 2.1e-29 102.3 0.2 2.8e-29 101.9 0.2 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 KOS16934.1 - 4.9e-28 97.7 0.1 8.6e-28 96.9 0.1 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PPR_2 PF13041.6 KOS16935.1 - 2.9e-07 30.6 0.2 0.00038 20.6 0.0 4.5 5 0 0 5 5 5 1 PPR repeat family TPR_6 PF13174.6 KOS16935.1 - 0.099 13.3 0.6 30 5.5 0.1 4.3 2 1 0 2 2 2 0 Tetratricopeptide repeat Peptidase_S9 PF00326.21 KOS16937.1 - 2e-58 197.4 0.1 3.4e-58 196.6 0.1 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family Esterase PF00756.20 KOS16937.1 - 0.0005 19.8 0.6 0.0011 18.7 0.6 1.5 1 0 0 1 1 1 1 Putative esterase PD40 PF07676.12 KOS16937.1 - 0.0018 18.2 0.0 0.0053 16.7 0.0 1.8 1 0 0 1 1 1 1 WD40-like Beta Propeller Repeat AXE1 PF05448.12 KOS16937.1 - 0.044 12.4 0.0 0.98 8.0 0.0 2.2 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Bromo_TP PF07524.13 KOS16938.1 - 8.2e-09 35.4 0.0 1.4e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated BSP_II PF05432.11 KOS16938.1 - 0.00017 21.4 18.1 0.0023 17.7 10.8 2.0 2 0 0 2 2 2 2 Bone sialoprotein II (BSP-II) TFIID-31kDa PF02291.15 KOS16938.1 - 0.0006 19.9 0.0 0.00093 19.3 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit DUF4820 PF16091.5 KOS16938.1 - 0.23 10.8 1.3 1.2 8.5 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DARPP-32 PF05395.12 KOS16938.1 - 0.48 10.6 9.3 0.072 13.3 2.5 2.1 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 Sigma70_ner PF04546.13 KOS16938.1 - 0.63 9.9 9.4 0.15 12.0 3.0 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region FYDLN_acid PF09538.10 KOS16938.1 - 0.85 10.3 11.8 0.82 10.4 5.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RXT2_N PF08595.11 KOS16938.1 - 1.6 8.7 9.3 1.2 9.1 3.5 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Myc_N PF01056.18 KOS16938.1 - 3.8 7.3 8.8 0.22 11.4 3.5 1.6 2 0 0 2 2 2 0 Myc amino-terminal region Pox_Ag35 PF03286.14 KOS16938.1 - 7.5 6.3 10.7 1.3 8.8 4.9 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Cnd3 PF12719.7 KOS16939.1 - 4.4e-90 301.8 2.5 4.9e-90 301.7 0.6 2.1 3 0 0 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 KOS16939.1 - 9.8e-09 35.5 8.9 1.5e-05 25.3 1.7 5.2 3 1 0 3 3 3 2 HEAT repeats HEAT PF02985.22 KOS16939.1 - 0.0009 19.3 10.9 0.31 11.4 0.0 6.6 7 0 0 7 7 7 1 HEAT repeat Cnd1 PF12717.7 KOS16939.1 - 0.0067 16.5 3.4 0.66 10.0 0.0 4.8 4 2 0 5 5 5 1 non-SMC mitotic condensation complex subunit 1 Snf7 PF03357.21 KOS16939.1 - 9.7 5.7 8.2 3.7 7.1 0.2 2.9 3 0 0 3 3 3 0 Snf7 RRM_1 PF00076.22 KOS16940.1 - 1e-56 188.6 0.1 1.5e-17 63.1 0.0 5.5 5 1 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_Rrp7 PF17799.1 KOS16940.1 - 0.00035 20.4 1.1 0.9 9.3 0.1 3.8 2 2 1 3 3 3 2 Rrp7 RRM-like N-terminal domain RRM_7 PF16367.5 KOS16940.1 - 0.0075 16.4 0.5 3.5 7.8 0.1 3.6 3 0 0 3 3 3 1 RNA recognition motif BUD22 PF09073.10 KOS16940.1 - 9.3 5.5 64.8 0.085 12.2 36.4 2.7 3 0 0 3 3 3 0 BUD22 Alg6_Alg8 PF03155.15 KOS16941.1 - 2.3e-173 577.6 24.2 2.7e-173 577.4 24.2 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Lectin_leg-like PF03388.13 KOS16942.1 - 6.7e-24 84.5 0.1 2.7e-23 82.5 0.0 1.9 2 0 0 2 2 2 1 Legume-like lectin family DUF5523 PF17661.1 KOS16942.1 - 0.00016 21.5 2.2 0.00021 21.0 2.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5523) TolA_bind_tri PF16331.5 KOS16942.1 - 0.0011 19.0 1.2 0.015 15.3 0.3 2.5 2 0 0 2 2 2 1 TolA binding protein trimerisation Macoilin PF09726.9 KOS16942.1 - 0.003 16.2 13.2 0.004 15.8 13.2 1.0 1 0 0 1 1 1 1 Macoilin family FliT PF05400.13 KOS16942.1 - 0.0091 16.8 0.3 0.021 15.6 0.3 1.5 1 0 0 1 1 1 1 Flagellar protein FliT Pox_Ag35 PF03286.14 KOS16942.1 - 0.011 15.5 3.2 0.016 15.0 3.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CPSF100_C PF13299.6 KOS16942.1 - 0.011 15.9 2.4 0.019 15.2 2.4 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FUSC PF04632.12 KOS16942.1 - 0.014 13.9 2.9 0.02 13.5 2.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF1192 PF06698.11 KOS16942.1 - 0.029 14.4 0.3 0.052 13.6 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) DUF4404 PF14357.6 KOS16942.1 - 0.035 14.7 0.9 0.11 13.2 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) ABC_tran_CTD PF16326.5 KOS16942.1 - 0.042 14.1 0.2 8.1 6.8 0.0 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain CLZ PF16526.5 KOS16942.1 - 0.12 12.7 1.2 0.24 11.8 0.7 1.8 1 1 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Trimer_CC PF08954.11 KOS16942.1 - 0.17 11.5 0.1 0.4 10.3 0.1 1.6 1 0 0 1 1 1 0 Trimerisation motif Secretin_N_2 PF07655.13 KOS16942.1 - 0.23 12.0 12.9 0.75 10.4 12.9 1.9 1 0 0 1 1 1 0 Secretin N-terminal domain GOLD_2 PF13897.6 KOS16942.1 - 0.36 11.3 1.6 0.69 10.4 1.6 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4407 PF14362.6 KOS16942.1 - 0.49 9.7 4.7 0.86 8.9 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Menin PF05053.13 KOS16942.1 - 2.7 6.3 13.0 3.7 5.8 13.0 1.1 1 0 0 1 1 1 0 Menin Apc15p PF05841.11 KOS16942.1 - 4.1 8.2 11.9 7.2 7.4 11.9 1.3 1 0 0 1 1 1 0 Apc15p protein FAM76 PF16046.5 KOS16942.1 - 6.6 6.0 11.1 10 5.3 11.1 1.2 1 0 0 1 1 1 0 FAM76 protein Presenilin PF01080.17 KOS16942.1 - 7.9 5.1 10.0 5.6 5.6 8.7 1.3 2 0 0 2 2 2 0 Presenilin POB3_N PF17292.2 KOS16943.1 - 1e-30 106.0 0.1 7.2e-29 100.1 0.1 2.6 2 0 0 2 2 2 1 POB3-like N-terminal PH domain SSrecog PF03531.14 KOS16943.1 - 2.1e-27 94.8 0.3 1.3e-26 92.3 0.0 2.5 2 0 0 2 2 2 1 Structure-specific recognition protein (SSRP1) Rtt106 PF08512.12 KOS16943.1 - 3.4e-22 78.7 0.0 1.3e-21 76.8 0.0 2.1 2 0 0 2 2 2 1 Histone chaperone Rttp106-like WAC_Acf1_DNA_bd PF10537.9 KOS16944.1 - 2.9e-37 127.2 0.0 2.9e-37 127.2 0.0 2.3 3 0 0 3 3 3 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 KOS16944.1 - 1.5e-17 63.8 0.1 1.5e-17 63.8 0.1 3.4 4 1 0 4 4 4 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 KOS16944.1 - 2.1e-15 56.8 1.2 3.6e-15 56.0 1.2 1.4 1 0 0 1 1 1 1 DDT domain WHIM1 PF15612.6 KOS16944.1 - 4.5e-09 35.6 0.0 1.3e-08 34.1 0.0 1.9 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF4852 PF16144.5 KOS16944.1 - 0.049 13.8 3.3 1.7 8.8 1.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4852) UPF0449 PF15136.6 KOS16944.1 - 5.8 7.4 13.1 0.29 11.6 5.6 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 RPN7 PF10602.9 KOS16945.1 - 5.5e-50 169.5 0.2 2e-49 167.7 0.3 1.9 3 0 0 3 3 3 1 26S proteasome subunit RPN7 PCI PF01399.27 KOS16945.1 - 2.8e-13 50.3 0.0 1.2e-12 48.3 0.0 2.1 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 KOS16945.1 - 0.0011 18.9 0.7 3 8.2 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS16945.1 - 0.13 12.1 0.7 4.7 7.2 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Prp18 PF02840.15 KOS16946.1 - 2.1e-52 177.0 0.0 2.1e-52 177.0 0.0 1.8 2 0 0 2 2 2 1 Prp18 domain PRP4 PF08799.11 KOS16946.1 - 2.9e-12 45.9 1.1 2.9e-12 45.9 1.1 3.2 3 1 0 3 3 3 1 pre-mRNA processing factor 4 (PRP4) like CDC27 PF09507.10 KOS16946.1 - 0.78 9.1 13.9 1.3 8.3 13.9 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 KOS16946.1 - 1.5 7.0 9.0 1.5 7.0 9.0 1.2 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M24 PF00557.24 KOS16947.1 - 3.1e-60 203.5 0.1 5.4e-60 202.7 0.1 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOS16947.1 - 1.7e-18 66.5 0.0 3.2e-18 65.6 0.0 1.4 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Fungal_trans PF04082.18 KOS16948.1 - 1.2e-22 80.2 0.3 1.2e-22 80.2 0.3 2.2 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS16948.1 - 7.4e-11 42.0 13.6 1.6e-10 40.9 13.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex2_Pex12 PF04757.14 KOS16948.1 - 0.013 15.1 0.1 0.013 15.1 0.1 2.2 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region Fer2 PF00111.27 KOS16948.1 - 0.11 12.4 1.6 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Gal4_dimer PF03902.13 KOS16948.1 - 0.18 12.0 0.2 0.6 10.3 0.2 1.9 1 0 0 1 1 1 0 Gal4-like dimerisation domain Menin PF05053.13 KOS16948.1 - 0.34 9.2 10.6 0.53 8.6 10.6 1.2 1 0 0 1 1 1 0 Menin SAP18 PF06487.12 KOS16949.1 - 2.5e-42 144.4 0.0 3.3e-42 144.0 0.0 1.1 1 0 0 1 1 1 1 Sin3 associated polypeptide p18 (SAP18) NDUF_B4 PF07225.12 KOS16950.1 - 0.0034 17.3 0.0 0.0036 17.2 0.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) Glyco_hydro_16 PF00722.21 KOS16951.1 - 3.1e-42 144.0 4.7 3.4e-42 143.9 3.7 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 PT PF04886.12 KOS16952.1 - 0.0001 21.7 1.6 0.00028 20.4 1.6 1.7 1 0 0 1 1 1 1 PT repeat NUDIX PF00293.28 KOS16953.1 - 5.7e-18 65.2 0.1 1.1e-17 64.2 0.0 1.4 2 0 0 2 2 2 1 NUDIX domain Ribosomal_S14 PF00253.21 KOS16954.1 - 6.4e-11 41.9 3.0 1.3e-10 40.8 2.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S14p/S29e Bot1p PF12298.8 KOS16954.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic mitochondrial regulator protein NUDIX PF00293.28 KOS16956.1 - 1e-07 32.0 3.1 2.3e-07 30.9 0.2 2.3 1 1 1 2 2 2 1 NUDIX domain Citrate_synt PF00285.21 KOS16957.1 - 1.2e-99 333.8 0.0 1.5e-99 333.5 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain PRR18 PF15671.5 KOS16958.1 - 0.048 13.5 0.7 0.087 12.7 0.7 1.3 1 0 0 1 1 1 0 Proline-rich protein family 18 adh_short_C2 PF13561.6 KOS16959.1 - 2.2e-59 200.9 0.2 2.5e-59 200.7 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS16959.1 - 2.8e-40 137.9 0.1 3.4e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS16959.1 - 2.7e-10 40.4 0.6 4e-10 39.9 0.6 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 KOS16959.1 - 1.4e-05 25.1 0.2 2.5e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Methyltransf_25 PF13649.6 KOS16959.1 - 0.0043 17.7 0.0 0.0091 16.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Polysacc_synt_2 PF02719.15 KOS16959.1 - 0.027 13.6 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 KOS16959.1 - 0.029 13.8 0.1 0.04 13.4 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family Methyltransf_12 PF08242.12 KOS16959.1 - 0.032 15.0 0.0 0.067 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain RecC_C PF17946.1 KOS16959.1 - 0.045 13.5 0.1 0.088 12.6 0.0 1.4 2 0 0 2 2 2 0 RecC C-terminal domain ChuX_HutX PF06228.13 KOS16959.1 - 0.09 12.5 0.1 3 7.6 0.0 2.4 1 1 1 2 2 2 0 Haem utilisation ChuX/HutX ICL PF00463.21 KOS16960.1 - 2.9e-198 659.6 0.1 3.4e-198 659.4 0.1 1.0 1 0 0 1 1 1 1 Isocitrate lyase family DUF3818 PF12825.7 KOS16961.1 - 1.4e-36 126.2 0.0 3.5e-22 78.9 0.0 2.9 1 1 1 2 2 2 2 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 KOS16961.1 - 2.7e-35 121.2 0.0 4.9e-35 120.4 0.0 1.4 1 0 0 1 1 1 1 PX-associated DUF4449 PF14613.6 KOS16962.1 - 1.5e-60 204.0 2.4 1.5e-60 204.0 2.4 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) Dna2 PF08696.11 KOS16962.1 - 3.1 7.6 5.6 0.76 9.5 1.2 2.0 2 0 0 2 2 2 0 DNA replication factor Dna2 MDM10 PF12519.8 KOS16963.1 - 9.2e-163 542.4 0.0 1e-162 542.2 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 KOS16963.1 - 0.01 15.4 0.9 0.44 10.0 0.1 3.0 4 0 0 4 4 4 0 Eukaryotic porin Plant_tran PF04827.14 KOS16963.1 - 0.14 11.7 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Plant transposon protein CPDase PF07823.11 KOS16963.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein Zip PF02535.22 KOS16964.1 - 3.3e-65 220.5 0.1 4.1e-65 220.2 0.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter BaxI_1 PF12811.7 KOS16964.1 - 2.5 7.6 9.9 1.8 8.1 1.1 2.6 3 0 0 3 3 3 0 Bax inhibitor 1 like SelK_SelG PF10961.8 KOS16964.1 - 9.7 6.9 10.8 35 5.1 0.0 2.5 1 1 1 2 2 2 0 Selenoprotein SelK_SelG Ribosomal_S19e PF01090.19 KOS16965.1 - 5.8e-59 197.7 0.1 6.6e-59 197.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e APOBEC3 PF18771.1 KOS16966.1 - 0.011 15.9 0.0 0.019 15.1 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 DEAD PF00270.29 KOS16967.1 - 6.5e-21 74.9 0.1 1.5e-20 73.7 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 KOS16967.1 - 9.7e-16 58.3 3.9 9.7e-16 58.3 3.9 1.9 2 0 0 2 2 2 1 RecQ zinc-binding Helicase_C PF00271.31 KOS16967.1 - 3.7e-15 56.2 0.0 2.8e-12 47.0 0.0 3.1 3 0 0 3 3 3 1 Helicase conserved C-terminal domain RQC PF09382.10 KOS16967.1 - 1.5e-14 53.8 0.4 4.1e-12 45.9 0.0 2.4 2 0 0 2 2 2 2 RQC domain ResIII PF04851.15 KOS16967.1 - 3e-08 33.9 0.0 5.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit BUD22 PF09073.10 KOS16967.1 - 0.0034 16.8 4.6 0.0034 16.8 4.6 1.8 2 0 0 2 2 2 1 BUD22 HRDC PF00570.23 KOS16967.1 - 0.0035 17.3 0.0 0.0075 16.2 0.0 1.6 1 0 0 1 1 1 1 HRDC domain Peripla_BP_4 PF13407.6 KOS16967.1 - 0.029 13.9 0.3 1.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Periplasmic binding protein domain SecA_DEAD PF07517.14 KOS16967.1 - 0.046 13.0 0.0 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 SecA DEAD-like domain HEM4 PF02602.15 KOS16967.1 - 0.067 12.5 0.5 0.82 9.0 0.2 2.3 2 0 0 2 2 2 0 Uroporphyrinogen-III synthase HemD KAR9 PF08580.10 KOS16968.1 - 1.4e-160 536.2 0.0 1.4e-160 536.2 0.0 4.3 3 2 1 4 4 4 1 Yeast cortical protein KAR9 Spectrin PF00435.21 KOS16968.1 - 0.17 12.4 3.9 68 4.0 0.0 4.0 3 2 0 3 3 3 0 Spectrin repeat Tim17 PF02466.19 KOS16969.1 - 1.4e-12 48.0 0.0 2.4e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family IF3_C PF00707.22 KOS16971.1 - 5.6e-05 23.0 0.0 8.4e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor IF-3, C-terminal domain mIF3 PF14877.6 KOS16971.1 - 0.0097 15.6 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial translation initiation factor AMP-binding PF00501.28 KOS16972.1 - 1e-48 166.0 0.0 1.7e-48 165.3 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS16972.1 - 5.6e-08 33.6 0.1 1.1e-07 32.7 0.1 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DEAD PF00270.29 KOS16973.1 - 2.5e-42 144.6 0.2 4.2e-42 143.9 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS16973.1 - 2.5e-33 114.8 0.0 9e-33 112.9 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 KOS16973.1 - 0.0003 20.6 0.1 0.00045 20.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 KOS16973.1 - 0.00042 20.4 0.0 0.00089 19.3 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 KOS16973.1 - 0.0014 19.0 0.2 0.01 16.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 KOS16973.1 - 0.048 13.1 0.0 0.099 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Flavi_DEAD PF07652.14 KOS16973.1 - 0.053 13.5 0.4 0.17 11.8 0.0 2.1 3 1 0 3 3 3 0 Flavivirus DEAD domain Helicase_RecD PF05127.14 KOS16973.1 - 0.08 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Helicase DUF5393 PF17371.2 KOS16973.1 - 0.1 10.7 0.1 0.16 10.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) AAA_22 PF13401.6 KOS16973.1 - 0.11 12.8 1.0 0.53 10.6 1.0 2.0 1 1 0 1 1 1 0 AAA domain Ribosomal_L34 PF00468.17 KOS16974.1 - 1.3e-10 41.1 11.5 1.3e-10 41.1 11.5 1.9 3 0 0 3 3 3 1 Ribosomal protein L34 LRR_6 PF13516.6 KOS16975.1 - 4.2e-06 26.4 0.0 0.0068 16.4 0.0 5.1 5 1 0 5 5 5 1 Leucine Rich repeat LEA_3 PF03242.13 KOS16975.1 - 0.35 11.6 3.9 0.79 10.5 3.9 1.6 1 0 0 1 1 1 0 Late embryogenesis abundant protein NinF PF05810.12 KOS16975.1 - 0.37 10.7 5.0 0.92 9.4 0.2 2.9 3 0 0 3 3 3 0 NinF protein Ribosomal_60s PF00428.19 KOS16975.1 - 2.1 9.0 7.5 11 6.7 7.5 2.1 1 1 0 1 1 1 0 60s Acidic ribosomal protein Lipase_3 PF01764.25 KOS16976.1 - 1.2e-31 109.5 0.0 1.6e-31 109.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Lipase3_N PF03893.16 KOS16976.1 - 0.0032 17.5 0.3 0.0073 16.3 0.3 1.5 1 0 0 1 1 1 1 Lipase 3 N-terminal region Abhydrolase_6 PF12697.7 KOS16976.1 - 0.0036 18.0 0.1 0.0053 17.4 0.1 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 KOS16976.1 - 0.05 13.7 0.1 0.086 12.9 0.1 1.3 1 0 0 1 1 1 0 Thioesterase domain dsrm PF00035.26 KOS16977.1 - 0.22 12.3 1.3 0.77 10.5 0.2 2.4 2 1 0 2 2 2 0 Double-stranded RNA binding motif DUF1682 PF07946.14 KOS16978.1 - 8.7e-106 353.8 0.0 1e-105 353.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF4407 PF14362.6 KOS16978.1 - 0.069 12.5 1.4 0.099 12.0 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SfLAP PF11139.8 KOS16979.1 - 0.058 12.8 0.1 0.058 12.8 0.1 1.6 2 0 0 2 2 2 0 Sap, sulfolipid-1-addressing protein DUF484 PF04340.12 KOS16979.1 - 0.079 12.6 0.1 0.12 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF484 Centro_C10orf90 PF17730.1 KOS16979.1 - 0.088 11.6 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Centrosomal C10orf90 SMC_N PF02463.19 KOS16980.1 - 4.8e-67 225.6 0.2 7.8e-67 224.9 0.2 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOS16980.1 - 1.4e-26 93.1 0.1 9.8e-26 90.4 0.0 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 KOS16980.1 - 5.2e-19 69.5 0.9 5.2e-19 69.5 0.9 7.0 2 2 4 6 6 3 1 AAA domain AAA_21 PF13304.6 KOS16980.1 - 1.1e-17 64.8 2.2 2.3e-08 34.2 0.0 3.6 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOS16980.1 - 1e-12 48.5 6.3 1e-12 48.5 6.3 3.5 2 1 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 KOS16980.1 - 0.00069 19.8 0.0 0.0027 17.9 0.0 2.1 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit MscS_porin PF12795.7 KOS16980.1 - 0.0031 17.1 16.2 0.0031 17.1 16.2 6.8 3 2 3 7 7 7 1 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 KOS16980.1 - 0.0038 16.9 0.0 0.0098 15.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.6 KOS16980.1 - 0.0054 16.1 6.3 0.0054 16.1 6.3 7.3 4 3 2 7 7 7 1 Growth-arrest specific micro-tubule binding KxDL PF10241.9 KOS16980.1 - 0.019 15.2 1.4 0.019 15.2 1.4 7.7 5 3 2 7 7 7 0 Uncharacterized conserved protein Laminin_II PF06009.12 KOS16980.1 - 0.024 14.6 0.7 0.024 14.6 0.7 7.0 4 2 2 7 7 7 0 Laminin Domain II DUF2326 PF10088.9 KOS16980.1 - 0.027 14.2 0.0 0.15 11.8 0.0 2.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) ABC_tran PF00005.27 KOS16980.1 - 0.35 11.4 0.0 0.35 11.4 0.0 6.2 3 2 0 3 3 1 0 ABC transporter DUF2935 PF11155.8 KOS16980.1 - 3.4 8.0 15.4 54 4.1 5.2 4.7 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Pinin_SDK_memA PF04696.13 KOS16981.1 - 2.8e-31 108.2 13.7 2.8e-31 108.2 13.7 1.9 1 1 1 2 2 2 1 pinin/SDK/memA/ protein conserved region RSB_motif PF16294.5 KOS16981.1 - 0.00015 21.9 5.5 0.00015 21.9 5.5 3.4 2 1 0 2 2 2 1 RNSP1-SAP18 binding (RSB) motif BRD4_CDT PF17105.5 KOS16981.1 - 0.028 14.0 1.9 0.028 14.0 1.9 3.6 3 1 1 4 4 4 0 C-terminal domain of bromodomain protein 4 PHF5 PF03660.14 KOS16982.1 - 7.3e-52 173.9 10.9 8.3e-52 173.8 10.9 1.0 1 0 0 1 1 1 1 PHF5-like protein PolC_DP2 PF03833.13 KOS16982.1 - 0.51 8.1 7.9 0.51 8.1 7.9 1.2 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 DZR PF12773.7 KOS16982.1 - 2.7 8.1 15.9 6.1 7.0 2.1 3.0 1 1 1 2 2 2 0 Double zinc ribbon GLEYA PF10528.9 KOS16983.1 - 5.4e-24 84.4 1.5 1e-23 83.6 1.5 1.5 1 0 0 1 1 1 1 GLEYA domain PA14 PF07691.12 KOS16983.1 - 3.2e-06 27.0 0.1 5.5e-06 26.3 0.1 1.4 1 0 0 1 1 1 1 PA14 domain Glycos_transf_1 PF00534.20 KOS16984.1 - 1.1e-20 73.9 0.0 2.2e-20 72.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOS16984.1 - 3.3e-13 50.2 0.0 5.6e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KOS16984.1 - 0.018 15.4 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 UvdE PF03851.14 KOS16985.1 - 3.9e-108 360.9 0.0 6.4e-108 360.2 0.0 1.3 1 0 0 1 1 1 1 UV-endonuclease UvdE DDHD PF02862.17 KOS16985.1 - 0.11 12.6 1.9 0.65 10.1 0.2 2.2 2 0 0 2 2 2 0 DDHD domain Presenilin PF01080.17 KOS16985.1 - 0.59 8.8 8.0 3.1 6.4 3.8 2.1 2 0 0 2 2 2 0 Presenilin FAM60A PF15396.6 KOS16985.1 - 2.2 8.2 8.3 1.1 9.2 2.6 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Fungal_trans PF04082.18 KOS16986.1 - 1.6e-09 37.2 0.0 2.9e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain TAF6_C PF07571.13 KOS16987.1 - 3e-27 94.8 0.1 6.8e-27 93.6 0.1 1.7 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 KOS16987.1 - 7.2e-21 74.1 0.2 1.2e-20 73.4 0.2 1.4 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) DDHD PF02862.17 KOS16987.1 - 0.013 15.7 0.1 0.018 15.2 0.1 1.3 1 0 0 1 1 1 0 DDHD domain Histone PF00125.24 KOS16987.1 - 0.013 15.9 0.1 0.013 15.9 0.1 2.3 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Spt20 PF12090.8 KOS16987.1 - 0.05 13.2 9.9 0.085 12.5 9.9 1.3 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 KOS16987.1 - 0.058 14.4 1.3 0.058 14.4 1.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TERB2 PF15101.6 KOS16987.1 - 0.094 12.8 2.1 0.17 11.9 2.1 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Lin-8 PF03353.15 KOS16987.1 - 0.098 12.2 3.8 0.18 11.3 3.8 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 KOS16987.1 - 0.11 11.2 0.2 0.13 11.0 0.2 1.2 1 0 0 1 1 1 0 Presenilin ADH_N PF08240.12 KOS16988.1 - 1e-25 89.7 5.0 1.7e-25 89.0 5.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS16988.1 - 1.2e-23 83.5 0.0 3.7e-23 81.9 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS16988.1 - 3.6e-09 37.8 0.0 6.5e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOS16988.1 - 0.00029 20.2 0.0 0.00052 19.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOS16988.1 - 0.0095 15.3 0.2 0.019 14.3 0.0 1.5 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Amino_oxidase PF01593.24 KOS16989.1 - 5.8e-11 42.3 0.1 2.7e-10 40.1 0.1 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS16989.1 - 3.3e-08 33.6 0.1 6.5e-08 32.7 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KOS16989.1 - 1.8e-07 30.9 0.1 3.4e-07 30.0 0.0 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS16989.1 - 7.5e-07 28.7 0.1 1.2e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS16989.1 - 8.8e-07 29.4 0.6 2e-06 28.2 0.2 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS16989.1 - 9.9e-06 24.9 0.0 1.4e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS16989.1 - 1.2e-05 25.1 0.4 3.2e-05 23.7 0.4 1.6 1 1 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS16989.1 - 5e-05 22.2 0.0 7.2e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 KOS16989.1 - 7.4e-05 22.1 0.0 0.00012 21.4 0.0 1.3 1 0 0 1 1 1 1 Thi4 family ApbA PF02558.16 KOS16989.1 - 0.0081 15.8 0.1 0.015 14.9 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 KOS16989.1 - 0.012 15.9 0.1 0.025 14.8 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Pyr_redox_3 PF13738.6 KOS16989.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOS16989.1 - 0.014 14.6 0.0 0.021 14.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain RskA PF10099.9 KOS16989.1 - 0.043 14.1 0.4 0.091 13.0 0.4 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Trp_halogenase PF04820.14 KOS16989.1 - 0.066 12.0 0.0 0.092 11.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase NAD_Gly3P_dh_N PF01210.23 KOS16989.1 - 0.079 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus YjeF_N PF03853.15 KOS16989.1 - 0.095 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 YjeF-related protein N-terminus Shikimate_DH PF01488.20 KOS16989.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sdh_cyt PF01127.22 KOS16990.1 - 1.2e-16 60.8 2.5 1.6e-16 60.4 2.5 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit SET PF00856.28 KOS16992.1 - 5.3e-19 69.2 0.0 1.3e-18 67.9 0.0 1.7 2 0 0 2 2 2 1 SET domain Rubis-subs-bind PF09273.11 KOS16992.1 - 1.5e-05 25.7 0.6 4.8e-05 24.0 0.6 2.0 1 1 0 1 1 1 1 Rubisco LSMT substrate-binding Opi1 PF08618.10 KOS16993.1 - 4.5e-40 138.2 10.0 2.4e-31 109.4 1.6 3.4 2 1 1 3 3 3 3 Transcription factor Opi1 Syntaxin-6_N PF09177.11 KOS16993.1 - 0.0029 18.1 0.4 0.57 10.8 0.1 2.3 2 0 0 2 2 2 2 Syntaxin 6, N-terminal Adap_comp_sub PF00928.21 KOS16994.1 - 1.5e-91 306.5 0.0 2.7e-91 305.6 0.0 1.4 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOS16994.1 - 4.4e-09 36.4 0.2 7.3e-09 35.7 0.2 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 KOS16994.1 - 0.084 12.3 0.0 0.29 10.5 0.0 1.8 2 0 0 2 2 2 0 Muniscin C-terminal mu homology domain TIP120 PF08623.10 KOS16995.1 - 6.8e-70 234.2 5.8 1.5e-67 226.6 0.1 4.7 3 1 2 5 5 4 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 KOS16995.1 - 3.6e-15 56.1 15.4 0.058 13.8 1.3 9.2 7 2 2 9 9 7 5 HEAT repeats HEAT PF02985.22 KOS16995.1 - 2e-13 49.3 22.5 0.19 12.1 0.1 11.2 12 0 0 12 12 11 5 HEAT repeat RTP1_C1 PF10363.9 KOS16995.1 - 2.9e-08 33.9 10.8 0.02 15.1 0.2 6.8 7 0 0 7 7 7 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 KOS16995.1 - 2.1e-07 31.1 11.6 0.006 16.6 0.3 5.2 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOS16995.1 - 7.8e-05 23.2 0.1 4.1 8.1 0.0 6.3 6 1 1 7 7 7 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 KOS16995.1 - 0.00019 20.1 10.8 0.093 11.3 0.1 6.6 6 2 0 7 7 7 1 Adaptin N terminal region DUF3361 PF11841.8 KOS16995.1 - 0.00083 19.3 1.2 25 4.8 0.1 4.8 4 1 1 5 5 5 0 Domain of unknown function (DUF3361) Cnd3 PF12719.7 KOS16995.1 - 0.0012 18.1 0.1 9 5.4 0.0 4.8 4 1 1 5 5 5 1 Nuclear condensing complex subunits, C-term domain U3snoRNP10 PF12397.8 KOS16995.1 - 0.0014 19.0 1.2 1.8 9.0 0.0 3.6 3 0 0 3 3 2 1 U3 small nucleolar RNA-associated protein 10 IFRD PF05004.13 KOS16995.1 - 0.0018 17.5 0.5 14 4.7 0.0 5.0 5 1 0 5 5 5 0 Interferon-related developmental regulator (IFRD) RasGEF_N_2 PF14663.6 KOS16995.1 - 0.033 14.6 0.1 1.4 9.4 0.1 3.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MMS19_C PF12460.8 KOS16995.1 - 0.066 12.3 14.5 0.46 9.5 0.8 5.2 6 0 0 6 6 6 0 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 KOS16995.1 - 0.073 13.6 28.5 4.3 7.9 0.0 10.8 13 0 0 13 13 10 0 HEAT-like repeat MMS19_N PF14500.6 KOS16995.1 - 0.082 12.5 6.2 1.1 8.8 0.4 4.5 5 1 1 6 6 6 0 Dos2-interacting transcription regulator of RNA-Pol-II VHS PF00790.19 KOS16995.1 - 0.13 12.1 0.0 4 7.3 0.0 2.9 2 0 0 2 2 2 0 VHS domain ParcG PF10274.9 KOS16995.1 - 6.9 6.7 8.1 86 3.2 0.0 4.8 6 0 0 6 6 6 0 Parkin co-regulated protein DNA_pol_phi PF04931.13 KOS16995.1 - 7.3 4.6 13.6 6.2 4.8 9.1 2.7 3 0 0 3 3 3 0 DNA polymerase phi RNA_pol_3_Rpc31 PF11705.8 KOS16995.1 - 9.2 6.4 11.9 15 5.7 11.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cpn60_TCP1 PF00118.24 KOS16996.1 - 3e-152 507.7 9.1 3.4e-152 507.5 9.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Hydrolase PF00702.26 KOS16996.1 - 0.089 13.1 5.4 0.029 14.7 1.4 2.4 2 2 0 2 2 2 0 haloacid dehalogenase-like hydrolase HMG_box PF00505.19 KOS16997.1 - 3e-05 24.4 1.2 9.4e-05 22.8 1.2 1.9 1 0 0 1 1 1 1 HMG (high mobility group) box Trypan_PARP PF05887.11 KOS16997.1 - 0.018 15.0 23.3 0.018 15.0 23.3 4.0 1 1 3 4 4 4 0 Procyclic acidic repetitive protein (PARP) BBP2_2 PF10082.9 KOS16997.1 - 0.17 10.7 5.3 0.35 9.7 5.2 1.5 1 1 0 1 1 1 0 Putative beta-barrel porin 2 Glyco_hydro_2 PF00703.21 KOS16997.1 - 0.78 10.4 10.2 0.44 11.2 1.2 2.7 1 1 1 2 2 2 0 Glycosyl hydrolases family 2 DUF155 PF02582.14 KOS16998.1 - 1.3e-52 178.4 0.3 1.9e-52 177.9 0.3 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 Ribosomal_L37ae PF01780.19 KOS16999.1 - 7.5e-39 131.7 10.7 8.4e-39 131.6 10.7 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 KOS16999.1 - 0.0057 16.6 3.7 0.0095 15.9 3.7 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 KOS16999.1 - 0.006 17.0 1.4 0.18 12.3 0.5 2.3 2 0 0 2 2 2 1 Zinc-finger double domain zf-RING_13 PF17977.1 KOS16999.1 - 0.0092 16.1 2.1 0.014 15.5 2.1 1.3 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain C1_2 PF03107.16 KOS16999.1 - 0.013 15.8 1.9 0.95 9.8 0.1 2.1 1 1 1 2 2 2 0 C1 domain DUF1451 PF07295.11 KOS16999.1 - 0.022 14.8 0.7 0.031 14.3 0.7 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain C1_1 PF00130.22 KOS16999.1 - 0.08 12.8 2.3 0.12 12.3 2.3 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Elf1 PF05129.13 KOS16999.1 - 0.11 12.6 3.3 0.16 12.0 3.3 1.4 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-BED PF02892.15 KOS16999.1 - 0.26 11.4 5.1 0.26 11.3 0.7 2.1 1 1 1 2 2 2 0 BED zinc finger Zn_ribbon_SprT PF17283.2 KOS16999.1 - 0.33 10.9 6.5 0.16 11.9 4.4 1.5 2 0 0 2 2 2 0 SprT-like zinc ribbon domain MRNIP PF15749.5 KOS16999.1 - 1.5 9.6 6.9 21 5.9 0.1 2.3 1 1 1 2 2 2 0 MRN-interacting protein FAD_binding_2 PF00890.24 KOS17000.1 - 1.6e-124 416.2 4.0 2e-124 415.9 4.0 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 KOS17000.1 - 1.7e-43 147.7 0.3 2.5e-43 147.1 0.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 KOS17000.1 - 1.9e-05 24.0 0.6 0.0024 17.1 0.2 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS17000.1 - 0.0001 21.6 0.2 0.1 11.9 0.1 2.3 2 0 0 2 2 2 2 Thi4 family GIDA PF01134.22 KOS17000.1 - 0.00015 21.0 1.0 0.046 12.8 1.9 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_3 PF01494.19 KOS17000.1 - 0.0012 18.2 0.1 0.0031 16.8 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS17000.1 - 0.16 11.5 1.7 0.32 10.5 1.7 1.6 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS17000.1 - 0.25 10.0 0.4 0.98 8.1 0.3 2.0 2 0 0 2 2 2 0 HI0933-like protein TPR_2 PF07719.17 KOS17001.1 - 0.024 14.7 0.9 0.2 11.9 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS17001.1 - 0.027 15.1 3.5 0.027 15.1 3.5 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOS17001.1 - 0.2 12.5 21.6 0.2 12.6 1.0 5.1 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOS17001.1 - 1.4 9.4 10.8 0.31 11.6 2.9 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat U3_snoRNA_assoc PF08297.11 KOS17002.1 - 1.1e-08 35.6 12.1 1.1e-08 35.6 12.1 3.1 2 1 1 3 3 3 1 U3 snoRNA associated CDC27 PF09507.10 KOS17002.1 - 0.15 11.4 26.2 0.19 11.1 26.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GREB1 PF15782.5 KOS17002.1 - 4.4 4.3 9.6 4.5 4.3 9.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VIR_N PF15912.5 KOS17002.1 - 6.1 6.4 8.3 8.3 5.9 8.3 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal PH_10 PF15411.6 KOS17003.1 - 4.9e-28 97.9 1.2 7.9e-28 97.2 1.2 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain VWA PF00092.28 KOS17003.1 - 4.5e-15 56.3 0.0 7.1e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 KOS17003.1 - 3.3e-10 40.1 0.0 8.2e-10 38.8 0.0 1.6 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOS17003.1 - 5.6e-08 33.4 0.1 1.9e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain PH PF00169.29 KOS17003.1 - 0.0077 16.7 0.1 0.016 15.7 0.1 1.5 1 0 0 1 1 1 1 PH domain DUF1147 PF06615.11 KOS17003.1 - 0.064 13.3 0.5 0.19 11.8 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1147) PHD PF00628.29 KOS17004.1 - 8.1e-08 32.0 3.6 1.5e-07 31.2 3.6 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOS17004.1 - 6.9e-05 22.3 2.7 0.00011 21.7 2.7 1.3 1 0 0 1 1 1 1 PHD-finger zf-PHD-like PF15446.6 KOS17004.1 - 0.071 12.7 0.4 0.17 11.5 0.2 1.7 1 1 0 1 1 1 0 PHD/FYVE-zinc-finger like domain FAM193_C PF15914.5 KOS17004.1 - 0.17 11.7 1.0 0.39 10.5 1.0 1.6 1 0 0 1 1 1 0 FAM193 family C-terminal MRP-L46 PF11788.8 KOS17005.1 - 6.4e-12 46.3 0.0 9.8e-12 45.7 0.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 NUDIX PF00293.28 KOS17005.1 - 0.0011 19.0 0.0 0.0027 17.8 0.0 1.7 1 1 0 1 1 1 1 NUDIX domain TAFII28 PF04719.14 KOS17006.1 - 8.3e-23 80.3 2.7 9.8e-19 67.3 0.0 2.6 2 0 0 2 2 2 2 hTAFII28-like protein conserved region Vfa1 PF08432.10 KOS17006.1 - 4.2 7.7 15.3 14 6.0 13.2 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.7 KOS17006.1 - 6.7 4.7 5.8 8.3 4.4 5.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 KOS17006.1 - 7.5 5.2 11.2 14 4.3 11.2 1.4 1 0 0 1 1 1 0 Presenilin DUF3381 PF11861.8 KOS17006.1 - 8 6.2 23.5 12 5.7 20.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Glyco_hydro_18 PF00704.28 KOS17008.1 - 1e-22 81.3 1.2 2.2e-22 80.2 1.2 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 KOS17008.1 - 8.1e-10 38.5 15.2 8.1e-10 38.5 15.2 2.6 3 0 0 3 3 3 1 Fungal cellulose binding domain Euplotes_phero PF05842.11 KOS17008.1 - 0.014 15.9 0.1 0.031 14.8 0.1 1.5 1 0 0 1 1 1 0 Euplotes octocarinatus mating pheromone protein DEC-1_N PF04625.13 KOS17008.1 - 2 7.4 3.5 3.6 6.5 3.5 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Pyr_redox_2 PF07992.14 KOS17009.1 - 7.8e-18 64.7 0.0 2.4e-13 50.0 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS17009.1 - 1.5e-06 27.6 0.1 1.3e-05 24.5 0.1 2.4 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_3 PF13738.6 KOS17009.1 - 1e-05 24.9 0.0 0.011 15.0 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS17009.1 - 1.5e-05 25.2 0.2 0.00023 21.3 0.2 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KOS17009.1 - 1.5e-05 24.3 0.1 0.0029 16.8 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 KOS17009.1 - 1.8e-05 24.8 0.5 0.014 15.4 0.0 2.3 2 0 0 2 2 2 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOS17009.1 - 2.1e-05 23.9 0.2 0.00032 20.0 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 KOS17009.1 - 5.9e-05 22.0 0.2 0.00016 20.5 0.1 1.8 3 0 0 3 3 3 1 HI0933-like protein Lycopene_cycl PF05834.12 KOS17009.1 - 0.00015 21.0 0.1 0.0022 17.1 0.1 2.0 2 0 0 2 2 2 1 Lycopene cyclase protein DAO PF01266.24 KOS17009.1 - 0.0003 20.5 1.8 0.0047 16.6 0.7 2.2 1 1 1 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KOS17009.1 - 0.005 16.2 0.6 0.0076 15.7 0.6 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOS17009.1 - 0.0052 16.1 0.1 0.0078 15.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KOS17009.1 - 0.017 14.4 0.2 0.031 13.5 0.2 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KOS17009.1 - 0.12 12.9 0.1 0.31 11.6 0.1 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS17009.1 - 0.19 10.6 0.0 0.31 9.9 0.0 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Glyco_hydro_127 PF07944.12 KOS17010.1 - 9.2e-21 73.9 0.0 3.3e-19 68.8 0.0 2.1 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Methyltransf_31 PF13847.6 KOS17011.1 - 3e-22 79.1 0.0 9.5e-22 77.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS17011.1 - 2.9e-17 63.2 0.0 1.4e-16 61.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17011.1 - 1.5e-13 51.2 0.0 6.1e-13 49.2 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17011.1 - 1.2e-12 48.4 0.0 2.7e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain EcKinase PF02958.20 KOS17011.1 - 4.8e-12 45.8 0.0 1.4e-11 44.3 0.0 1.7 1 1 0 1 1 1 1 Ecdysteroid kinase Methyltransf_23 PF13489.6 KOS17011.1 - 3.5e-11 43.2 0.0 9.1e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain APH PF01636.23 KOS17011.1 - 1.3e-09 38.4 1.4 1.3e-09 38.4 1.4 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Methyltransf_4 PF02390.17 KOS17011.1 - 2.3e-06 27.2 0.0 4.2e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.18 KOS17011.1 - 3.4e-06 26.6 0.0 6e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KOS17011.1 - 6.5e-06 25.8 0.0 1.6e-05 24.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 KOS17011.1 - 6.8e-06 25.5 0.1 1.5e-05 24.4 0.1 1.5 1 1 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 KOS17011.1 - 0.00078 19.2 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DUF938 PF06080.12 KOS17011.1 - 0.016 15.0 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_18 PF12847.7 KOS17011.1 - 0.034 14.1 0.0 0.068 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOS17011.1 - 0.037 14.0 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain CagA PF03507.13 KOS17011.1 - 0.046 13.7 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 CagA exotoxin CMAS PF02353.20 KOS17011.1 - 0.05 12.9 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Choline_kinase PF01633.20 KOS17011.1 - 0.074 12.6 0.0 0.19 11.3 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase GCD14 PF08704.10 KOS17011.1 - 0.075 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit AcylCoA_DH_N PF12418.8 KOS17011.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.6 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase N terminal Methyltransf_15 PF09445.10 KOS17011.1 - 0.21 11.1 0.0 0.36 10.4 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PSDC PF12588.8 KOS17012.1 - 2.2e-58 196.2 0.0 3.5e-58 195.6 0.0 1.3 1 0 0 1 1 1 1 Phophatidylserine decarboxylase PS_Dcarbxylase PF02666.15 KOS17012.1 - 1.7e-33 115.9 0.0 2.9e-33 115.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 KOS17012.1 - 0.0012 18.7 0.3 0.17 11.7 0.4 2.4 2 0 0 2 2 2 2 Biotin-lipoyl like Formyl_trans_N PF00551.19 KOS17013.1 - 1.7e-35 122.4 0.1 2.2e-35 122.0 0.1 1.2 1 0 0 1 1 1 1 Formyl transferase ACT PF01842.25 KOS17013.1 - 1.3e-08 34.5 1.7 2.2e-08 33.7 0.0 2.4 2 1 0 2 2 2 1 ACT domain ACT_6 PF13740.6 KOS17013.1 - 0.00078 19.4 0.0 0.004 17.1 0.0 2.2 2 1 1 3 3 3 1 ACT domain ZnuA PF01297.17 KOS17013.1 - 0.13 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Thymidylate_kin PF02223.17 KOS17014.1 - 1.6e-40 138.8 0.0 3e-40 137.9 0.0 1.4 2 0 0 2 2 2 1 Thymidylate kinase AAA_28 PF13521.6 KOS17014.1 - 0.0048 17.2 0.0 0.011 16.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain CPT PF07931.12 KOS17014.1 - 0.024 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein KTI12 PF08433.10 KOS17014.1 - 0.05 13.0 0.0 0.092 12.2 0.0 1.4 1 1 0 1 1 1 0 Chromatin associated protein KTI12 Glyco_hyd_65N_2 PF14498.6 KOS17015.1 - 2.4e-49 168.3 0.0 3.6e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Hemocyanin_N PF03722.14 KOS17015.1 - 0.72 10.4 2.6 85 3.7 0.3 3.3 3 0 0 3 3 3 0 Hemocyanin, all-alpha domain SRP54 PF00448.22 KOS17016.1 - 4.9e-77 258.0 1.9 6.8e-77 257.5 0.7 1.8 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 KOS17016.1 - 1.5e-30 105.7 4.9 1.5e-30 105.7 4.9 4.0 3 2 2 5 5 3 1 Signal peptide binding domain SRP54_N PF02881.19 KOS17016.1 - 2e-21 76.0 0.4 5.4e-21 74.6 0.4 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain cobW PF02492.19 KOS17016.1 - 1.5e-07 31.2 0.7 1.4e-06 28.0 0.7 2.4 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 KOS17016.1 - 4.5e-07 30.1 0.4 1.4e-06 28.5 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KOS17016.1 - 7.2e-05 23.2 1.7 0.00013 22.4 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOS17016.1 - 0.00028 21.3 0.1 0.00072 20.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 KOS17016.1 - 0.00031 19.8 3.4 0.00049 19.2 0.7 2.5 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 KOS17016.1 - 0.00033 20.0 0.0 0.00073 18.9 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin Thymidylate_kin PF02223.17 KOS17016.1 - 0.00096 18.9 0.3 0.011 15.5 0.0 2.4 2 0 0 2 2 2 1 Thymidylate kinase APS_kinase PF01583.20 KOS17016.1 - 0.0015 18.4 0.0 0.0031 17.4 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase CbiA PF01656.23 KOS17016.1 - 0.0019 18.2 0.0 0.0058 16.7 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 KOS17016.1 - 0.0025 17.5 1.0 0.0058 16.4 0.1 2.1 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 KOS17016.1 - 0.0026 17.8 0.1 0.068 13.2 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 KOS17016.1 - 0.0029 17.1 0.7 3 7.2 0.7 3.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit ResIII PF04851.15 KOS17016.1 - 0.0036 17.3 0.4 0.073 13.1 0.4 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit MobB PF03205.14 KOS17016.1 - 0.0049 16.8 0.1 0.027 14.4 0.0 2.2 3 0 0 3 3 3 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 KOS17016.1 - 0.0063 17.1 0.0 0.016 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS17016.1 - 0.0082 16.4 0.0 0.026 14.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOS17016.1 - 0.0087 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 KOS17016.1 - 0.011 15.6 0.4 0.052 13.3 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein NTPase_1 PF03266.15 KOS17016.1 - 0.013 15.5 1.0 0.73 9.7 0.1 2.4 1 1 1 2 2 2 0 NTPase Glyco_trans_4_4 PF13579.6 KOS17016.1 - 0.029 14.8 0.0 0.057 13.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain AAA_19 PF13245.6 KOS17016.1 - 0.034 14.5 1.1 0.073 13.4 1.1 1.8 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 KOS17016.1 - 0.039 13.2 0.0 0.064 12.5 0.0 1.4 1 0 0 1 1 1 0 6-phosphofructo-2-kinase Arf PF00025.21 KOS17016.1 - 0.097 12.1 0.1 0.33 10.4 0.0 1.9 2 0 0 2 2 1 0 ADP-ribosylation factor family AAA PF00004.29 KOS17016.1 - 0.11 12.9 0.7 0.47 10.9 0.2 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 KOS17016.1 - 0.13 12.2 0.1 1 9.2 0.0 2.2 1 1 1 2 2 2 0 AAA domain SKA2 PF16740.5 KOS17016.1 - 0.44 10.4 5.5 13 5.6 0.1 2.7 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 PLAC8 PF04749.17 KOS17017.1 - 5.4e-06 27.3 0.8 7.1e-06 27.0 0.8 1.2 1 0 0 1 1 1 1 PLAC8 family bZIP_1 PF00170.21 KOS17019.1 - 0.00056 19.9 0.9 0.24 11.5 0.0 3.6 1 1 2 3 3 3 1 bZIP transcription factor PspA_IM30 PF04012.12 KOS17019.1 - 0.00086 18.9 1.1 0.00086 18.9 1.1 3.3 1 1 1 3 3 3 1 PspA/IM30 family bZIP_2 PF07716.15 KOS17019.1 - 0.001 19.1 4.3 1 9.5 0.3 4.1 4 0 0 4 4 3 1 Basic region leucine zipper DUF1664 PF07889.12 KOS17019.1 - 0.0023 18.0 4.8 8.2 6.5 0.0 3.7 2 1 2 4 4 3 0 Protein of unknown function (DUF1664) CENP-F_leu_zip PF10473.9 KOS17019.1 - 0.0023 18.0 4.1 0.0023 18.0 4.1 2.7 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tektin PF03148.14 KOS17019.1 - 0.0024 16.7 7.9 0.015 14.0 0.0 2.6 2 1 1 3 3 3 2 Tektin family HOOK PF05622.12 KOS17019.1 - 0.0029 15.8 3.9 0.0044 15.3 3.9 1.2 1 0 0 1 1 1 1 HOOK protein Jnk-SapK_ap_N PF09744.9 KOS17019.1 - 0.0032 17.7 3.9 0.0032 17.7 3.9 2.9 2 1 1 3 3 3 1 JNK_SAPK-associated protein-1 KASH_CCD PF14662.6 KOS17019.1 - 0.0051 16.7 3.1 0.026 14.3 3.1 2.0 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH ATG16 PF08614.11 KOS17019.1 - 0.0094 16.2 10.9 0.036 14.3 10.9 2.0 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KOS17019.1 - 0.013 15.9 1.0 20 5.7 0.0 4.4 1 1 4 5 5 5 0 Flagella accessory protein C (FlaC) Yuri_gagarin PF15934.5 KOS17019.1 - 0.015 15.1 1.2 0.028 14.3 1.2 1.5 1 0 0 1 1 1 0 Yuri gagarin MCC-bdg_PDZ PF10506.9 KOS17019.1 - 0.016 15.2 0.7 2.8 8.0 0.0 3.3 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome HMMR_N PF15905.5 KOS17019.1 - 0.026 14.0 2.4 0.051 13.0 2.4 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Filament PF00038.21 KOS17019.1 - 0.027 14.1 6.6 0.66 9.5 2.8 2.5 1 1 2 3 3 3 0 Intermediate filament protein BLOC1_2 PF10046.9 KOS17019.1 - 0.035 14.4 2.5 0.68 10.3 0.2 3.4 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HAUS-augmin3 PF14932.6 KOS17019.1 - 0.043 13.4 4.5 0.52 9.8 0.1 2.2 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Atg14 PF10186.9 KOS17019.1 - 0.044 12.9 2.9 0.074 12.1 2.9 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ZapB PF06005.12 KOS17019.1 - 0.045 14.2 10.7 0.2 12.1 0.1 4.2 2 1 2 4 4 3 0 Cell division protein ZapB ADIP PF11559.8 KOS17019.1 - 0.046 13.8 3.8 0.054 13.6 0.4 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding GAS PF13851.6 KOS17019.1 - 0.052 12.9 1.6 0.14 11.5 1.6 1.8 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 KOS17019.1 - 0.059 12.8 7.9 0.03 13.8 4.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Mod_r PF07200.13 KOS17019.1 - 0.068 13.3 0.9 0.17 12.0 0.5 2.0 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Fib_alpha PF08702.10 KOS17019.1 - 0.072 13.3 1.4 12 6.1 0.0 3.3 3 1 1 4 4 3 0 Fibrinogen alpha/beta chain family Laminin_II PF06009.12 KOS17019.1 - 0.082 12.9 5.9 0.33 11.0 0.8 3.4 2 1 1 3 3 3 0 Laminin Domain II DUF4763 PF15960.5 KOS17019.1 - 0.083 12.2 4.9 0.35 10.1 3.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Macoilin PF09726.9 KOS17019.1 - 0.1 11.2 8.5 2 6.9 8.6 2.0 1 1 1 2 2 2 0 Macoilin family DUF3450 PF11932.8 KOS17019.1 - 0.24 10.7 8.3 0.49 9.7 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 KOS17019.1 - 0.27 10.6 11.7 0.25 10.6 3.8 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 KOS17019.1 - 0.35 11.1 5.1 1.9 8.7 0.3 2.8 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 KOS17019.1 - 0.43 11.0 7.4 1.6 9.2 6.3 2.3 1 1 0 1 1 1 0 Fez1 APG6_N PF17675.1 KOS17019.1 - 0.53 10.8 4.0 1.6 9.3 4.0 1.9 1 0 0 1 1 1 0 Apg6 coiled-coil region CENP-H PF05837.12 KOS17019.1 - 0.56 10.6 11.3 2.2 8.7 1.2 3.1 2 1 1 3 3 2 0 Centromere protein H (CENP-H) PhageMin_Tail PF10145.9 KOS17019.1 - 0.6 9.9 9.3 7.5 6.4 5.6 2.5 1 1 1 2 2 2 0 Phage-related minor tail protein Spc7 PF08317.11 KOS17019.1 - 0.65 8.8 5.2 1.2 7.9 3.3 1.7 1 1 0 1 1 1 0 Spc7 kinetochore protein Tropomyosin_1 PF12718.7 KOS17019.1 - 0.69 10.1 5.5 1.8 8.7 0.3 3.0 1 1 1 2 2 2 0 Tropomyosin like DUF948 PF06103.11 KOS17019.1 - 1 9.7 4.5 20 5.6 1.4 3.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CREPT PF16566.5 KOS17019.1 - 1.2 9.3 9.0 5.1 7.3 2.5 3.1 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour LPP PF04728.13 KOS17019.1 - 5.2 7.5 9.5 12 6.4 0.2 4.7 3 1 2 5 5 5 0 Lipoprotein leucine-zipper HIP1_clath_bdg PF16515.5 KOS17019.1 - 5.6 7.6 11.6 0.85 10.3 0.3 3.0 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TPR_MLP1_2 PF07926.12 KOS17019.1 - 6.2 6.9 11.5 0.62 10.1 3.0 3.4 3 1 1 4 4 3 0 TPR/MLP1/MLP2-like protein DUF1843 PF08898.10 KOS17019.1 - 7 7.2 10.4 15 6.1 0.3 4.5 5 0 0 5 5 3 0 Domain of unknown function (DUF1843) Seryl_tRNA_N PF02403.22 KOS17019.1 - 8.8 6.6 9.3 1.6 9.0 2.1 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Ribosomal_L1 PF00687.21 KOS17020.1 - 1.9e-25 89.8 0.1 2.4e-25 89.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family COG2 PF06148.11 KOS17021.1 - 4.8e-26 91.4 0.4 8e-26 90.7 0.4 1.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Vps51 PF08700.11 KOS17021.1 - 0.0011 19.0 0.4 0.0036 17.4 0.0 2.1 3 0 0 3 3 2 1 Vps51/Vps67 COG5 PF10392.9 KOS17021.1 - 0.0027 17.9 0.1 0.0051 17.0 0.1 1.5 1 0 0 1 1 1 1 Golgi transport complex subunit 5 Vps54_N PF10475.9 KOS17021.1 - 0.0057 16.0 0.0 0.068 12.4 0.0 2.0 1 1 1 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex Spc7 PF08317.11 KOS17021.1 - 0.022 13.6 1.7 0.033 13.1 1.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Dor1 PF04124.12 KOS17021.1 - 0.024 13.3 1.2 0.037 12.7 1.2 1.2 1 0 0 1 1 1 0 Dor1-like family NPV_P10 PF05531.12 KOS17021.1 - 0.052 14.0 0.6 0.28 11.7 0.1 2.5 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein TPR_MLP1_2 PF07926.12 KOS17021.1 - 0.11 12.6 2.4 2.6 8.1 0.9 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Zw10 PF06248.13 KOS17021.1 - 0.46 9.0 1.1 0.62 8.6 1.1 1.1 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 RRN3 PF05327.11 KOS17021.1 - 1.2 7.6 3.9 1.4 7.3 3.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 KOS17021.1 - 2.9 7.1 12.7 4.5 6.5 12.7 1.3 1 0 0 1 1 1 0 NOA36 protein DUF3295 PF11702.8 KOS17021.1 - 4.4 6.6 11.5 1.3 8.3 8.7 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) GCIP PF13324.6 KOS17021.1 - 6.5 6.3 6.4 11 5.5 6.4 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Hap4_Hap_bind PF10297.9 KOS17022.1 - 2.2e-09 37.1 6.9 1.2e-08 34.7 6.9 2.4 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 bZIP_1 PF00170.21 KOS17022.1 - 0.00021 21.3 11.3 0.00021 21.3 11.3 2.1 2 0 0 2 2 2 1 bZIP transcription factor CNTF PF01110.17 KOS17022.1 - 0.012 15.0 0.5 0.019 14.3 0.5 1.2 1 0 0 1 1 1 0 Ciliary neurotrophic factor dsrm PF00035.26 KOS17022.1 - 0.044 14.5 0.1 0.29 11.9 0.0 2.4 2 1 1 3 3 3 0 Double-stranded RNA binding motif S_4TM PF18159.1 KOS17022.1 - 2.6 7.2 4.5 5.7 6.2 4.6 1.4 2 0 0 2 2 2 0 SMODS-associating 4TM effector domain Fmp27_WPPW PF10359.9 KOS17022.1 - 3.3 6.5 10.3 4.7 5.9 10.3 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain F-box PF00646.33 KOS17024.1 - 5.3e-05 23.0 0.3 0.00014 21.6 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS17024.1 - 0.00056 19.8 0.5 0.0017 18.2 0.5 1.9 1 0 0 1 1 1 1 F-box-like FAD_binding_4 PF01565.23 KOS17027.1 - 5e-15 55.5 0.0 8.6e-15 54.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DEAD PF00270.29 KOS17028.1 - 1.6e-47 161.6 0.0 3.5e-47 160.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17028.1 - 4.1e-26 91.5 0.0 1.4e-24 86.6 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOS17028.1 - 6.7e-20 71.1 0.6 1.5e-19 69.9 0.6 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 KOS17028.1 - 4.5e-05 22.8 0.0 0.0001 21.6 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 KOS17028.1 - 5.3e-05 23.3 0.0 0.00015 21.8 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit KAP_NTPase PF07693.14 KOS17028.1 - 0.14 11.4 0.1 0.52 9.5 0.1 1.9 2 0 0 2 2 2 0 KAP family P-loop domain AAA_22 PF13401.6 KOS17028.1 - 0.3 11.4 1.1 0.73 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Pox_Ag35 PF03286.14 KOS17028.1 - 2.3 8.0 10.7 3.6 7.3 10.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Trypan_PARP PF05887.11 KOS17028.1 - 5.5 7.0 13.0 9.4 6.2 13.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Aa_trans PF01490.18 KOS17029.1 - 1.6e-51 175.3 39.7 1.8e-51 175.1 39.7 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein ATG27 PF09451.10 KOS17029.1 - 0.16 11.8 1.2 0.26 11.1 1.2 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 NOB1_Zn_bind PF08772.11 KOS17030.1 - 3.2e-32 110.5 4.1 5.5e-32 109.7 4.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like PIN_6 PF17146.4 KOS17030.1 - 7.8e-30 103.2 0.0 1.5e-29 102.3 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease HypA PF01155.19 KOS17030.1 - 0.014 15.4 0.0 0.41 10.7 0.6 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-NADH-PPase PF09297.11 KOS17030.1 - 0.014 15.0 0.5 0.014 15.0 0.5 1.8 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DUF2321 PF10083.9 KOS17030.1 - 0.1 12.2 0.6 0.21 11.2 0.6 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) PIN_5 PF08745.11 KOS17030.1 - 0.2 11.0 0.1 4.9 6.5 0.0 2.6 2 1 1 3 3 3 0 PINc domain ribonuclease Zn-ribbon_8 PF09723.10 KOS17030.1 - 2.2 8.5 5.2 0.91 9.7 2.4 1.9 2 0 0 2 2 2 0 Zinc ribbon domain WRNPLPNID PF15017.6 KOS17030.1 - 6 7.8 13.8 0.8 10.6 7.5 2.5 2 1 0 2 2 2 0 Putative WW-binding domain and destruction box tRNA-synt_1e PF01406.19 KOS17031.1 - 1.5e-115 385.7 0.0 2.1e-115 385.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 KOS17031.1 - 3.9e-05 22.6 0.2 0.23 10.2 0.0 2.5 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1f PF01921.18 KOS17031.1 - 0.035 13.0 0.1 4.1 6.2 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (K) tRNA-synt_1c PF00749.21 KOS17031.1 - 0.094 11.6 0.0 0.25 10.2 0.0 1.7 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF883 PF05957.13 KOS17031.1 - 0.57 10.8 6.4 11 6.8 0.0 3.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) GCD14 PF08704.10 KOS17032.1 - 1.2e-60 205.2 1.0 1.8e-57 194.8 0.0 3.4 2 1 0 2 2 2 1 tRNA methyltransferase complex GCD14 subunit MFS_1 PF07690.16 KOS17033.1 - 1.2e-31 109.9 30.6 1.2e-31 109.9 30.6 1.5 1 1 1 2 2 2 2 Major Facilitator Superfamily TMEM100 PF16311.5 KOS17033.1 - 0.27 10.8 0.0 0.27 10.8 0.0 2.7 3 0 0 3 3 3 0 Transmembrane protein 100 TFIIE-A_C PF11521.8 KOS17033.1 - 0.6 10.4 4.0 1.1 9.6 4.0 1.3 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha DUF3759 PF12585.8 KOS17034.1 - 1.2e-26 92.5 10.2 1.5e-26 92.2 10.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) Peptidase_C32 PF05411.12 KOS17034.1 - 0.0012 18.8 0.0 0.0015 18.4 0.0 1.2 1 0 0 1 1 1 1 Equine arteritis virus putative proteinase DUF1294 PF06961.13 KOS17034.1 - 0.045 14.0 1.0 4.9 7.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1294) eIF-3_zeta PF05091.12 KOS17035.1 - 0.22 10.5 1.1 0.37 9.7 1.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) MS_channel PF00924.18 KOS17036.1 - 3.5e-19 69.2 0.3 6.2e-19 68.4 0.3 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_1 PF00036.32 KOS17036.1 - 0.0006 19.2 0.5 0.0015 18.0 0.5 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOS17036.1 - 0.0065 15.9 0.1 0.019 14.4 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOS17036.1 - 0.0066 16.9 0.0 0.017 15.5 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair DUF1282 PF06930.12 KOS17036.1 - 0.0099 15.7 0.2 0.0099 15.7 0.2 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF1282) EF-hand_6 PF13405.6 KOS17036.1 - 0.011 15.6 0.1 0.036 14.0 0.1 1.9 1 0 0 1 1 1 0 EF-hand domain BRCT PF00533.26 KOS17037.1 - 5.9e-08 33.0 0.0 1.4e-07 31.8 0.0 1.6 1 1 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOS17037.1 - 4.9e-06 26.9 0.0 0.00077 19.8 0.0 2.5 2 1 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 KOS17037.1 - 6.5e-06 26.1 0.0 0.065 13.3 0.0 2.3 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 KOS17037.1 - 8.5e-05 22.4 0.0 0.00014 21.6 0.0 1.3 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain LSM PF01423.22 KOS17039.1 - 5.3e-08 32.4 0.1 8.5e-08 31.8 0.1 1.3 1 0 0 1 1 1 1 LSM domain Iron_permease PF04120.12 KOS17041.1 - 6.9e-43 145.5 4.8 1.9e-19 69.7 0.1 4.1 4 0 0 4 4 4 4 Low affinity iron permease DUF2839 PF10999.8 KOS17041.1 - 0.00087 19.6 0.6 0.00087 19.6 0.6 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2839) PBS_linker_poly PF00427.21 KOS17041.1 - 0.0019 18.3 0.2 0.0035 17.4 0.2 1.3 1 0 0 1 1 1 1 Phycobilisome Linker polypeptide CPP1-like PF11833.8 KOS17041.1 - 4.7 6.8 12.2 2.9 7.5 0.2 3.1 4 0 0 4 4 4 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Nop10p PF04135.12 KOS17042.1 - 5.7e-21 74.3 0.1 6.5e-21 74.1 0.1 1.0 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family SAM_decarbox PF01536.16 KOS17043.1 - 1.1e-52 179.2 0.0 1.4e-52 178.9 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase ParA PF10609.9 KOS17045.1 - 9.7e-78 261.0 0.0 1.2e-77 260.7 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KOS17045.1 - 0.0051 16.9 0.0 2.4 8.2 0.0 2.6 2 1 0 2 2 2 2 CobQ/CobB/MinD/ParA nucleotide binding domain Glyoxal_oxid_N PF07250.11 KOS17046.1 - 0.15 11.3 1.4 0.18 11.0 1.4 1.1 1 0 0 1 1 1 0 Glyoxal oxidase N-terminus NMO PF03060.15 KOS17048.1 - 5.1e-49 167.4 0.3 8.4e-49 166.7 0.3 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 KOS17048.1 - 3.3e-08 32.9 2.4 2e-07 30.3 2.4 2.0 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOS17048.1 - 0.0019 17.3 9.2 0.0029 16.7 9.2 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NTF2 PF02136.20 KOS17049.1 - 0.0071 16.9 1.1 0.08 13.5 1.1 2.1 1 1 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Mtr2 PF10429.9 KOS17049.1 - 0.086 12.8 0.0 0.27 11.2 0.0 1.8 1 1 0 1 1 1 0 Nuclear pore RNA shuttling protein Mtr2 TPR_14 PF13428.6 KOS17050.1 - 0.54 11.2 3.9 3.2 8.8 0.0 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat PPTA PF01239.22 KOS17051.1 - 2.9e-39 131.7 17.9 2.2e-08 33.5 0.2 6.0 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat DUF1148 PF06618.11 KOS17051.1 - 0.037 14.2 0.7 12 6.1 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1148) GHMP_kinases_N PF00288.26 KOS17052.1 - 4.3e-16 58.9 0.0 1.1e-15 57.6 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOS17052.1 - 2.5e-09 37.4 0.0 6.2e-09 36.1 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal Ribosomal_L38e PF01781.18 KOS17053.1 - 3.7e-34 116.6 3.5 4.1e-34 116.5 3.5 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family Pkinase PF00069.25 KOS17055.1 - 1.3e-43 149.3 0.0 1.6e-43 149.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17055.1 - 1.7e-12 47.2 0.0 2.9e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS17055.1 - 0.035 14.0 3.9 0.048 13.6 0.1 2.5 1 1 2 3 3 3 0 Phosphotransferase enzyme family Acetyltransf_3 PF13302.7 KOS17056.1 - 2.1e-21 77.0 0.0 2.8e-21 76.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 KOS17056.1 - 1.6e-05 24.6 1.4 0.12 12.1 0.1 3.0 3 0 0 3 3 3 2 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS17056.1 - 0.0047 16.9 0.2 2.2 8.3 0.0 2.4 2 0 0 2 2 2 2 FR47-like protein Acetyltransf_1 PF00583.25 KOS17056.1 - 0.022 15.0 0.1 0.14 12.4 0.1 2.1 2 1 0 2 2 2 0 Acetyltransferase (GNAT) family CnrY PF17524.2 KOS17056.1 - 0.095 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Anti-sigma factor CnrY tRNA-synt_1g PF09334.11 KOS17057.1 - 7.9e-94 314.6 2.5 5e-93 311.9 2.5 1.9 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KOS17057.1 - 1.5e-22 79.6 5.5 1.4e-10 40.1 0.1 3.1 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 KOS17057.1 - 1.3e-08 34.5 0.0 0.0032 16.9 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain PEPCK_N PF17297.2 KOS17057.1 - 0.035 13.7 0.1 0.098 12.3 0.0 1.8 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase N-terminal domain DALR_2 PF09190.11 KOS17057.1 - 0.045 14.2 0.4 0.17 12.4 0.2 2.2 2 0 0 2 2 2 0 DALR domain Porphobil_deam PF01379.20 KOS17059.1 - 1.1e-76 256.8 0.0 1.6e-76 256.4 0.0 1.2 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 KOS17059.1 - 8.7e-17 61.3 0.3 2e-16 60.1 0.3 1.6 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain VGLL4 PF15245.6 KOS17060.1 - 8.9 6.3 8.7 0.34 11.0 2.7 1.7 2 0 0 2 2 2 0 Transcription cofactor vestigial-like protein 4 Fungal_trans PF04082.18 KOS17061.1 - 2.4e-09 36.6 1.1 3.5e-09 36.1 1.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain AAA_lid_2 PF17863.1 KOS17061.1 - 0.024 14.5 0.2 0.084 12.7 0.0 2.0 2 0 0 2 2 2 0 AAA lid domain adh_short PF00106.25 KOS17062.1 - 1.6e-19 70.1 0.1 2.2e-19 69.7 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS17062.1 - 3.8e-11 43.0 0.1 4.6e-11 42.7 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 KOS17062.1 - 0.0035 16.8 0.1 0.054 12.9 0.0 2.3 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family p450 PF00067.22 KOS17063.1 - 3.5e-29 101.9 0.0 5.4e-29 101.3 0.0 1.3 1 1 0 1 1 1 1 Cytochrome P450 Glyco_hydro_3_C PF01915.22 KOS17064.1 - 4.2e-45 154.2 0.1 2e-44 152.0 0.0 2.2 2 1 0 2 2 2 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS17064.1 - 2e-41 142.4 0.0 3.1e-41 141.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS17064.1 - 4.6e-23 81.1 0.1 8.6e-23 80.2 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF11 PF01345.18 KOS17064.1 - 0.0054 17.0 3.8 0.026 14.8 3.8 2.1 1 1 0 1 1 1 1 Domain of unknown function DUF11 CARDB PF07705.11 KOS17064.1 - 0.014 15.7 0.0 0.034 14.4 0.0 1.6 1 0 0 1 1 1 0 CARDB CH PF00307.31 KOS17065.1 - 2.5e-15 56.6 0.0 5.2e-15 55.6 0.0 1.5 1 0 0 1 1 1 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 KOS17065.1 - 0.011 15.6 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 CAMSAP CH domain NDUFA12 PF05071.16 KOS17066.1 - 5.9e-10 39.8 1.0 1e-09 39.1 0.2 1.8 2 1 0 2 2 2 1 NADH ubiquinone oxidoreductase subunit NDUFA12 tRNA_int_endo PF01974.17 KOS17067.1 - 8.6e-18 64.2 0.0 1.9e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 KOS17067.1 - 4.9e-05 22.9 0.0 0.051 13.2 0.0 2.3 2 0 0 2 2 2 2 tRNA intron endonuclease, N-terminal domain zf-C2H2_jaz PF12171.8 KOS17068.1 - 1.4e-31 108.1 23.7 0.00043 20.5 0.2 10.6 11 0 0 11 11 11 7 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS17068.1 - 2.8e-31 107.0 36.5 0.00024 21.4 0.2 11.4 12 0 0 12 12 11 7 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KOS17068.1 - 2.4e-26 90.1 27.8 0.025 15.4 0.1 11.4 11 0 0 11 11 11 7 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS17068.1 - 9.6e-25 85.6 29.6 0.0045 17.4 0.1 11.2 11 0 0 11 11 11 8 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KOS17068.1 - 4e-12 45.8 36.3 0.086 12.9 0.2 9.6 8 1 1 9 9 9 5 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KOS17068.1 - 6.9e-12 44.9 27.1 0.18 11.6 0.0 9.4 10 0 0 10 10 10 5 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KOS17068.1 - 4.2e-11 43.1 42.3 0.2 12.0 2.3 9.0 3 1 6 9 9 9 6 C2H2 type zinc-finger (2 copies) DUF4187 PF13821.6 KOS17068.1 - 0.04 13.7 2.5 4.4 7.2 0.0 4.2 4 1 1 5 5 5 0 Domain of unknown function (DUF4187) DUF3246 PF11596.8 KOS17068.1 - 0.15 11.5 1.0 0.24 10.8 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Baculo_IE-1 PF05290.11 KOS17068.1 - 0.8 9.6 7.8 10 6.0 0.0 5.0 4 2 0 4 4 4 0 Baculovirus immediate-early protein (IE-0) Spt20 PF12090.8 KOS17068.1 - 1.9 8.0 29.5 4.3 6.9 29.5 1.6 1 0 0 1 1 1 0 Spt20 family zf_UBZ PF18439.1 KOS17068.1 - 2 8.1 18.0 2.7 7.7 0.2 6.2 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger eIF-3_zeta PF05091.12 KOS17068.1 - 2.1 7.2 15.5 2.8 6.8 15.5 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GREB1 PF15782.5 KOS17068.1 - 4.6 4.2 15.0 5.5 4.0 15.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Zn-C2H2_12 PF18112.1 KOS17068.1 - 7.2 7.2 10.7 21 5.7 0.0 5.1 5 0 0 5 5 5 0 Autophagy receptor zinc finger-C2H2 domain PLATZ PF04640.14 KOS17071.1 - 1.2 9.9 7.5 1.7 9.3 5.2 2.2 1 1 1 2 2 2 0 PLATZ transcription factor C1_2 PF03107.16 KOS17071.1 - 2.1 8.8 8.7 3.9 7.9 8.7 1.6 1 1 0 1 1 1 0 C1 domain PsaN PF05479.11 KOS17072.1 - 0.016 15.4 0.1 0.041 14.1 0.1 1.6 1 0 0 1 1 1 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) Glucosamine_iso PF01182.20 KOS17073.1 - 2.3e-69 233.7 0.0 2.7e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase SET PF00856.28 KOS17074.1 - 0.0014 19.0 0.0 0.0062 16.9 0.0 2.0 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 KOS17074.1 - 0.17 12.0 0.7 3.3 8.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-MYND PF01753.18 KOS17074.1 - 1.8 8.7 9.2 0.074 13.2 2.3 2.2 2 0 0 2 2 2 0 MYND finger ADH_N PF08240.12 KOS17075.1 - 9.6e-05 22.2 0.0 0.00026 20.8 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS17075.1 - 0.025 14.6 0.2 0.058 13.4 0.2 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF3759 PF12585.8 KOS17076.1 - 1.4e-36 124.4 3.9 1.8e-36 124.0 3.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3759) NCBP3 PF10309.9 KOS17076.1 - 0.065 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 NDK PF00334.19 KOS17077.1 - 3.9e-53 179.1 0.0 4.4e-53 178.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Glyco_hydro_31 PF01055.26 KOS17078.1 - 1.6e-143 479.1 2.3 2.6e-143 478.4 2.3 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOS17078.1 - 2.6e-24 85.3 0.5 8.8e-24 83.6 0.2 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 KOS17078.1 - 2.4e-06 27.7 0.5 8.3e-06 26.0 0.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) FLILHELTA PF10306.9 KOS17080.1 - 3.7e-32 110.6 0.1 6.2e-32 109.8 0.1 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA DUF1279 PF06916.13 KOS17080.1 - 0.00091 19.7 0.1 0.0014 19.2 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1279) PhoLip_ATPase_C PF16212.5 KOS17081.1 - 2.7e-81 273.0 18.5 2.7e-81 273.0 18.5 1.9 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOS17081.1 - 8.8e-28 95.8 5.2 2.2e-27 94.5 5.2 1.7 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KOS17081.1 - 1.2e-11 44.5 0.0 1.1e-10 41.4 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOS17081.1 - 2.3e-11 44.4 1.2 2.3e-05 24.8 0.1 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOS17081.1 - 3.7e-07 29.8 0.0 9.2e-07 28.6 0.0 1.7 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOS17081.1 - 0.0021 17.9 0.4 0.0072 16.1 0.4 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Mt_ATP-synt_B PF05405.14 KOS17081.1 - 0.012 15.2 0.1 0.026 14.1 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Glyco_hydro_18 PF00704.28 KOS17082.1 - 2.6e-14 53.7 0.0 3.7e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Abhydrolase_1 PF00561.20 KOS17083.1 - 3e-19 69.7 0.2 2.5e-16 60.1 0.2 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS17083.1 - 3.1e-15 57.4 16.5 5.8e-15 56.5 16.5 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS17083.1 - 2.2e-11 43.5 0.1 2.1e-09 37.0 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Chlorophyllase2 PF12740.7 KOS17083.1 - 0.0015 17.5 0.0 0.0022 16.9 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOS17083.1 - 0.056 12.4 0.0 0.093 11.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase DUF1688 PF07958.11 KOS17085.1 - 7e-183 608.1 0.0 7.9e-183 607.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) TOM13 PF08219.11 KOS17087.1 - 1.3e-36 124.4 0.0 1.7e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Outer membrane protein TOM13 60KD_IMP PF02096.20 KOS17088.1 - 3.2e-11 43.4 1.0 5.5e-11 42.6 1.0 1.4 1 0 0 1 1 1 1 60Kd inner membrane protein LXG PF04740.12 KOS17088.1 - 0.13 12.0 0.3 0.21 11.3 0.3 1.2 1 0 0 1 1 1 0 LXG domain of WXG superfamily Gtr1_RagA PF04670.12 KOS17089.1 - 1.8e-90 302.4 0.0 2.2e-90 302.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 KOS17089.1 - 6.1e-09 35.7 0.0 1.1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS17089.1 - 3.1e-08 33.8 0.0 5.6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS17089.1 - 5.5e-08 32.4 0.0 8.2e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS17089.1 - 5.3e-07 29.7 0.0 9.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KOS17089.1 - 0.0036 16.5 2.5 0.44 9.7 0.6 2.6 2 1 1 3 3 3 2 G-protein alpha subunit AAA_29 PF13555.6 KOS17089.1 - 0.0042 16.8 0.4 0.038 13.7 0.1 2.2 2 0 0 2 2 2 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KOS17089.1 - 0.0065 17.0 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter DUF815 PF05673.13 KOS17089.1 - 0.016 14.4 0.0 0.035 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 KOS17089.1 - 0.02 14.8 0.5 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 KOS17089.1 - 0.026 14.0 0.0 0.5 9.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region SRPRB PF09439.10 KOS17089.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit SEP PF08059.13 KOS17090.1 - 5.2e-25 87.8 0.0 1e-24 86.9 0.0 1.5 1 0 0 1 1 1 1 SEP domain UBA_4 PF14555.6 KOS17090.1 - 6.9e-11 41.8 0.9 1.1e-10 41.2 0.9 1.3 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 KOS17090.1 - 4.6e-09 36.3 0.0 7.6e-09 35.7 0.0 1.4 1 0 0 1 1 1 1 UBX domain TAP_C PF03943.13 KOS17090.1 - 1.2e-06 28.1 0.7 1.9e-06 27.4 0.7 1.3 1 0 0 1 1 1 1 TAP C-terminal domain BDHCT_assoc PF16204.5 KOS17090.1 - 0.047 13.4 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 BDHCT-box associated domain on Bloom syndrome protein DEC-1_N PF04625.13 KOS17090.1 - 0.44 9.5 3.9 0.79 8.7 3.9 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region TrkH PF02386.16 KOS17091.1 - 6.8e-71 239.2 0.2 2.8e-64 217.4 0.0 2.9 2 1 0 2 2 2 2 Cation transport protein Cu_amine_oxid PF01179.20 KOS17092.1 - 0.012 14.6 0.2 0.25 10.2 0.4 2.0 2 0 0 2 2 2 0 Copper amine oxidase, enzyme domain Joubert PF15392.6 KOS17092.1 - 0.02 14.7 8.1 0.023 14.4 8.1 1.1 1 0 0 1 1 1 0 Joubert syndrome-associated SPOB_a PF14689.6 KOS17092.1 - 0.052 13.3 5.8 1.6 8.5 0.4 2.3 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain TFIIA PF03153.13 KOS17092.1 - 0.061 13.3 15.5 0.062 13.3 15.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 KOS17092.1 - 0.35 9.6 6.0 0.37 9.5 6.0 1.0 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 KOS17092.1 - 0.45 9.5 6.3 0.5 9.4 6.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein GET2 PF08690.10 KOS17092.1 - 0.47 10.1 6.5 0.53 9.9 6.5 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Activator_LAG-3 PF11498.8 KOS17092.1 - 0.61 9.0 25.0 0.72 8.8 25.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Suf PF05843.14 KOS17092.1 - 0.74 9.7 6.9 0.76 9.7 6.9 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Band_3_cyto PF07565.13 KOS17092.1 - 0.84 9.4 4.2 0.95 9.2 4.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Spt20 PF12090.8 KOS17092.1 - 0.93 9.1 19.5 1.2 8.7 19.5 1.2 1 0 0 1 1 1 0 Spt20 family Neur_chan_memb PF02932.16 KOS17092.1 - 1.4 8.9 3.0 1.4 8.9 3.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 KOS17092.1 - 1.6 8.5 5.1 1.9 8.3 5.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 KOS17092.1 - 4.3 6.2 14.1 5.4 5.9 14.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) NPR3 PF03666.13 KOS17092.1 - 9.9 4.8 7.9 12 4.5 7.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_transf_21 PF13506.6 KOS17093.1 - 8e-14 51.5 0.1 3.3e-07 29.9 0.0 3.5 2 1 1 3 3 3 3 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 KOS17093.1 - 1.5e-07 31.5 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KOS17093.1 - 0.00036 20.4 0.0 0.0013 18.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 2 Sugar_tr PF00083.24 KOS17094.1 - 3e-31 108.8 29.2 4.2e-30 105.0 29.2 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17094.1 - 1.5e-29 103.0 38.0 6.6e-25 87.8 16.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1282 PF06930.12 KOS17094.1 - 2.1 8.1 9.9 0.26 11.0 5.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1282) AMPK1_CBM PF16561.5 KOS17095.1 - 0.0026 17.9 0.0 0.0032 17.6 0.0 1.1 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Zw10 PF06248.13 KOS17096.1 - 2.2e-12 46.4 0.8 5e-05 22.1 1.8 3.1 3 0 0 3 3 3 2 Centromere/kinetochore Zw10 Dsl1_C PF11989.8 KOS17096.1 - 0.013 15.2 0.0 0.052 13.3 0.0 2.1 2 0 0 2 2 2 0 Retrograde transport protein Dsl1 C terminal Exonuc_VII_S PF02609.16 KOS17096.1 - 0.066 13.3 0.1 0.86 9.7 0.0 2.9 2 0 0 2 2 2 0 Exonuclease VII small subunit SPESP1 PF15754.5 KOS17096.1 - 0.085 12.0 5.1 0.17 11.1 5.1 1.4 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 GBP_C PF02841.14 KOS17096.1 - 1.9 7.8 9.3 0.33 10.3 0.7 2.5 3 0 0 3 3 3 0 Guanylate-binding protein, C-terminal domain PI-PLC-X PF00388.19 KOS17097.1 - 1.5e-58 196.5 0.0 2.7e-58 195.7 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOS17097.1 - 5.7e-43 145.9 0.3 2.1e-42 144.1 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain PH_12 PF16457.5 KOS17097.1 - 0.00027 21.5 0.4 0.0013 19.2 0.4 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain EF-hand_like PF09279.11 KOS17097.1 - 0.0017 18.8 0.1 0.0068 16.9 0.0 2.0 2 0 0 2 2 2 1 Phosphoinositide-specific phospholipase C, efhand-like Peptidase_M48_N PF16491.5 KOS17098.1 - 2.6e-64 216.5 4.5 2.6e-64 216.5 4.5 1.8 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 KOS17098.1 - 8e-46 156.3 0.1 1.5e-45 155.4 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 KOS17098.1 - 2.3e-05 23.8 0.1 3.6e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 BlaR1 peptidase M56 DUF4538 PF15061.6 KOS17098.1 - 0.001 18.7 0.4 0.0026 17.4 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4538) Peptidase_M16_C PF05193.21 KOS17099.1 - 2.2e-17 63.6 0.0 6.8e-14 52.3 0.0 3.7 4 1 1 5 5 5 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOS17099.1 - 4.3e-08 33.3 0.1 2.9e-06 27.3 0.0 2.8 3 0 0 3 3 3 1 Insulinase (Peptidase family M16) M16C_assoc PF08367.11 KOS17099.1 - 9.3e-05 21.7 0.3 0.071 12.2 1.0 2.2 2 0 0 2 2 2 2 Peptidase M16C associated M16C_assoc PF08367.11 KOS17100.1 - 1.2e-83 280.1 0.0 2.4e-83 279.1 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 KOS17100.1 - 3.7e-29 102.0 0.0 2.7e-19 69.9 0.0 3.4 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 KOS17100.1 - 0.00071 19.6 0.1 0.028 14.4 0.1 3.0 2 1 0 2 2 2 1 Insulinase (Peptidase family M16) UvrA_inter PF17760.1 KOS17100.1 - 0.024 14.7 0.6 0.089 12.9 0.1 2.1 2 0 0 2 2 2 0 UvrA interaction domain Taxilin PF09728.9 KOS17101.1 - 5.6e-90 301.6 61.1 5.6e-90 301.6 61.1 1.9 2 0 0 2 2 2 1 Myosin-like coiled-coil protein DUF4810 PF16068.5 KOS17101.1 - 0.0089 16.5 0.2 0.0089 16.5 0.2 4.2 3 2 0 4 4 4 1 Domain of unknown function (DUF4810) MAD PF05557.13 KOS17101.1 - 0.5 8.7 59.0 1.1 7.5 21.4 2.2 1 1 1 2 2 2 0 Mitotic checkpoint protein SNF2_N PF00176.23 KOS17102.1 - 5.7e-37 127.2 0.1 1.9e-35 122.2 0.0 2.5 2 1 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS17102.1 - 7.5e-10 39.1 0.1 2.2e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 KOS17102.1 - 1.8e-06 27.7 11.3 1.8e-06 27.7 11.3 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS17102.1 - 0.00037 20.8 12.8 0.00037 20.8 12.8 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOS17102.1 - 0.0017 18.2 11.0 0.0017 18.2 11.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17102.1 - 0.003 17.3 11.0 0.003 17.3 11.0 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ERCC3_RAD25_C PF16203.5 KOS17102.1 - 0.042 13.0 0.1 0.072 12.3 0.1 1.4 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Zn_Tnp_IS91 PF14319.6 KOS17102.1 - 1.5 8.9 14.0 3.7 7.7 5.1 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-RING_10 PF16685.5 KOS17102.1 - 7.3 6.8 15.3 0.22 11.7 6.4 2.5 2 0 0 2 2 2 0 zinc RING finger of MSL2 Orn_Arg_deC_N PF02784.16 KOS17103.1 - 3.8e-82 275.4 0.0 5.8e-82 274.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 KOS17103.1 - 1.9e-17 63.3 0.0 2.6e-17 62.9 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain DHHC PF01529.20 KOS17104.1 - 1.3e-38 132.1 7.5 2.3e-38 131.4 7.5 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase zf-C2H2_4 PF13894.6 KOS17105.1 - 9.2e-08 32.3 8.8 3.7 8.7 0.0 5.5 5 0 0 5 5 5 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS17105.1 - 7.1e-05 23.0 7.6 3.8 8.2 0.3 5.2 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KOS17105.1 - 0.0059 16.6 5.9 0.16 12.0 0.3 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger FOXP-CC PF16159.5 KOS17105.1 - 0.013 16.1 1.0 1.2 9.8 0.1 3.2 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-Di19 PF05605.12 KOS17105.1 - 0.016 15.5 11.7 0.16 12.2 2.0 3.5 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 KOS17105.1 - 0.039 14.4 1.2 3.6 8.1 0.0 3.1 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger IBR PF01485.21 KOS17105.1 - 0.053 13.8 0.1 0.053 13.8 0.1 2.8 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain Zn-ribbon_8 PF09723.10 KOS17105.1 - 0.12 12.6 5.0 0.43 10.8 1.7 3.2 2 1 0 2 2 2 0 Zinc ribbon domain DZR PF12773.7 KOS17105.1 - 0.14 12.2 0.3 0.14 12.2 0.3 2.7 3 0 0 3 3 2 0 Double zinc ribbon zf-C2H2_2 PF12756.7 KOS17105.1 - 0.15 12.4 7.1 43 4.5 0.2 4.7 3 2 2 5 5 5 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 KOS17105.1 - 0.16 12.4 1.3 29 5.2 0.1 4.0 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-4CXXC_R1 PF10497.9 KOS17105.1 - 0.19 12.0 4.8 1.6 9.0 1.1 2.4 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-C2H2_9 PF16293.5 KOS17105.1 - 0.56 10.1 2.2 1.1e+02 2.7 0.0 3.8 4 1 0 4 4 4 0 C2H2 type zinc-finger (1 copy) HypA PF01155.19 KOS17105.1 - 0.58 10.2 3.1 0.86 9.7 0.3 2.5 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-H2C2_2 PF13465.6 KOS17105.1 - 4.4 7.9 11.2 1.1 9.8 0.8 4.0 4 0 0 4 4 4 0 Zinc-finger double domain Pkinase PF00069.25 KOS17106.1 - 8e-60 202.4 0.0 1.2e-59 201.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17106.1 - 9e-20 71.0 0.0 1.5e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17106.1 - 2.4e-06 27.1 0.0 4e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOS17106.1 - 0.00026 20.1 0.0 0.0004 19.5 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 KOS17106.1 - 0.013 15.1 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase_fungal PF17667.1 KOS17106.1 - 0.029 13.1 0.9 0.051 12.4 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KOS17106.1 - 0.036 14.0 0.1 0.078 12.9 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Codanin-1_C PF15296.6 KOS17106.1 - 0.35 11.0 1.2 0.64 10.1 0.0 2.0 2 0 0 2 2 2 0 Codanin-1 C-terminus zinc_ribbon_10 PF10058.9 KOS17106.1 - 0.46 10.3 1.5 17 5.3 0.1 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein CBS PF00571.28 KOS17108.1 - 1.2e-24 86.5 6.8 3.4e-10 40.2 0.4 4.3 4 0 0 4 4 4 4 CBS domain MARVEL PF01284.23 KOS17109.1 - 1.1e-06 28.8 11.3 1.6e-06 28.2 11.3 1.3 1 0 0 1 1 1 1 Membrane-associating domain Erf4 PF10256.9 KOS17109.1 - 0.074 13.2 0.3 0.13 12.3 0.3 1.6 1 0 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DUF3449 PF11931.8 KOS17111.1 - 1.8e-77 259.3 0.5 1.8e-77 259.3 0.5 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 KOS17111.1 - 5.4e-27 94.1 0.1 1.1e-26 93.1 0.1 1.5 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 SF3a60_bindingd PF12108.8 KOS17111.1 - 1.7e-10 40.6 0.3 3.2e-10 39.7 0.3 1.5 1 0 0 1 1 1 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 KOS17111.1 - 3.4e-08 33.6 2.8 7.6e-06 26.1 0.6 2.4 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOS17111.1 - 6.6e-07 29.5 0.8 6.6e-07 29.5 0.8 2.8 2 1 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KOS17111.1 - 0.0025 18.1 0.7 0.19 12.1 0.5 2.9 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) DUF4088 PF13317.6 KOS17111.1 - 0.031 13.9 0.8 0.07 12.7 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4088) PRP9_N PF16958.5 KOS17111.1 - 0.067 13.2 19.3 0.059 13.4 1.4 3.6 3 2 1 4 4 4 0 Pre-mRNA-splicing factor PRP9 N-terminus zf-C2H2_4 PF13894.6 KOS17111.1 - 0.077 13.9 1.1 12 7.1 0.1 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger IFT46_B_C PF12317.8 KOS17111.1 - 0.14 11.8 0.4 0.6 9.8 0.0 2.1 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal zf-U1 PF06220.12 KOS17111.1 - 0.17 11.7 0.7 0.43 10.4 0.7 1.7 1 0 0 1 1 1 0 U1 zinc finger zf-C2H2 PF00096.26 KOS17111.1 - 0.73 10.4 4.3 3.2 8.4 0.4 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type Ank_4 PF13637.6 KOS17112.1 - 1e-14 54.6 0.8 3.3e-07 30.7 0.1 2.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS17112.1 - 1.5e-14 53.8 0.5 6.2e-08 32.8 0.2 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS17112.1 - 9.4e-13 48.6 0.1 2.6e-05 24.7 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOS17112.1 - 3.3e-08 33.6 0.2 8.6e-05 22.8 0.3 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_3 PF13606.6 KOS17112.1 - 6.9e-08 32.2 0.0 0.0039 17.6 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat PARP_reg PF02877.14 KOS17113.1 - 7.3e-40 136.2 0.0 1.3e-39 135.4 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain PARP PF00644.20 KOS17113.1 - 3.7e-29 101.7 0.8 2.6e-22 79.4 0.0 2.9 2 1 1 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain WGR PF05406.15 KOS17113.1 - 2.6e-23 81.9 0.3 5e-23 81.0 0.3 1.5 1 0 0 1 1 1 1 WGR domain BRCT PF00533.26 KOS17113.1 - 2.4e-10 40.7 0.0 1.7e-09 37.9 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KOS17113.1 - 4.6e-08 32.9 0.1 1e-07 31.8 0.1 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 KOS17113.1 - 4.2e-06 27.1 0.0 1e-05 25.9 0.0 1.6 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KOS17113.1 - 0.026 14.8 0.1 0.068 13.5 0.1 1.7 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain Efg1 PF10153.9 KOS17114.1 - 2.5e-29 101.9 11.7 2.5e-29 101.9 11.7 2.8 2 1 0 2 2 2 1 rRNA-processing protein Efg1 Collagen PF01391.18 KOS17114.1 - 0.15 11.9 6.7 0.054 13.3 3.3 1.9 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) DUF4726 PF15855.5 KOS17115.1 - 0.0088 16.2 0.2 0.029 14.6 0.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4726) PPP4R2 PF09184.11 KOS17115.1 - 0.22 11.1 4.0 0.068 12.8 0.6 1.7 2 0 0 2 2 2 0 PPP4R2 DUF3246 PF11596.8 KOS17115.1 - 3.7 6.9 4.6 2.8 7.3 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) TauD PF02668.16 KOS17117.1 - 3.8e-30 105.6 0.0 5.7e-30 105.0 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 KOS17117.1 - 6.7e-05 23.5 0.0 0.00014 22.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF971) CsiD PF08943.10 KOS17117.1 - 0.098 11.8 0.0 0.15 11.2 0.0 1.2 1 0 0 1 1 1 0 CsiD SGS PF05002.15 KOS17118.1 - 4.9e-28 97.1 1.6 1.3e-27 95.7 1.6 1.7 1 0 0 1 1 1 1 SGS domain CS PF04969.16 KOS17118.1 - 9.2e-10 39.4 0.1 1.7e-09 38.6 0.1 1.4 1 0 0 1 1 1 1 CS domain TPR_16 PF13432.6 KOS17118.1 - 0.00075 20.1 13.4 0.0034 18.0 1.4 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS17118.1 - 0.0015 18.5 6.6 5.2 7.4 2.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOS17118.1 - 0.68 9.9 8.8 0.41 10.5 5.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PTS_2-RNA PF01885.16 KOS17119.1 - 2.8e-62 210.0 0.0 3.3e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family DSPc PF00782.20 KOS17120.1 - 5.9e-26 90.8 0.0 3.6e-24 85.1 0.0 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOS17120.1 - 0.0027 17.3 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KOS17120.1 - 0.15 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) T2SSB PF16537.5 KOS17120.1 - 0.17 11.5 0.0 0.33 10.6 0.0 1.4 1 0 0 1 1 1 0 Type II secretion system protein B Init_tRNA_PT PF04179.12 KOS17120.1 - 0.17 12.2 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 Rit1 DUSP-like domain UAA PF08449.11 KOS17121.1 - 1.4e-44 152.5 5.7 2e-44 152.0 5.7 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOS17121.1 - 5.8e-07 29.8 29.1 2.1e-05 24.7 10.2 3.5 3 1 0 3 3 3 3 EamA-like transporter family Nuc_sug_transp PF04142.15 KOS17121.1 - 3e-06 26.6 1.7 0.011 14.9 0.1 2.2 2 0 0 2 2 2 2 Nucleotide-sugar transporter CRT-like PF08627.10 KOS17121.1 - 0.00081 18.4 1.9 0.32 9.9 0.0 2.2 2 0 0 2 2 2 2 CRT-like, chloroquine-resistance transporter-like TPT PF03151.16 KOS17121.1 - 0.0061 16.0 5.5 0.24 10.7 0.4 2.3 2 0 0 2 2 2 2 Triose-phosphate Transporter family KH_1 PF00013.29 KOS17122.1 - 1.6e-40 136.8 11.0 5.1e-16 58.3 0.1 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOS17122.1 - 4.2e-09 36.1 10.9 0.013 15.3 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOS17122.1 - 9.7e-09 35.0 4.2 0.013 15.3 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KOS17122.1 - 9.1e-05 22.5 6.3 0.23 11.6 0.1 3.4 3 0 0 3 3 3 3 NusA-like KH domain MOEP19 PF16005.5 KOS17122.1 - 0.0083 16.1 0.1 6.6 6.8 0.0 2.7 3 0 0 3 3 3 2 KH-like RNA-binding domain Homeodomain PF00046.29 KOS17124.1 - 5.5e-20 71.0 4.1 1.3e-19 69.8 4.1 1.6 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOS17124.1 - 0.00087 19.1 0.5 0.0022 17.8 0.5 1.7 1 0 0 1 1 1 1 Homeobox KN domain MIP-T3_C PF17749.1 KOS17124.1 - 0.086 12.8 3.9 0.13 12.2 3.9 1.2 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Adaptin_binding PF10199.9 KOS17125.1 - 4.7e-11 43.3 4.2 1.1e-10 42.2 4.2 1.7 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Serglycin PF04360.12 KOS17126.1 - 0.044 13.7 0.2 0.08 12.9 0.2 1.4 1 0 0 1 1 1 0 Serglycin SQHop_cyclase_C PF13243.6 KOS17127.1 - 1.5e-49 168.9 0.4 3.6e-47 161.0 0.5 2.4 2 1 0 2 2 2 2 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 KOS17127.1 - 1.2e-42 146.0 3.6 3.7e-36 124.7 0.2 3.6 4 0 0 4 4 4 2 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 KOS17127.1 - 4e-30 103.3 8.8 1.9e-09 37.1 0.5 5.8 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 KOS17127.1 - 7.1e-05 22.0 0.5 0.065 12.2 0.3 3.6 3 1 1 4 4 4 2 A-macroglobulin TED domain Pec_lyase PF09492.10 KOS17127.1 - 0.00048 19.6 0.0 0.84 8.9 0.0 3.4 3 0 0 3 3 3 1 Pectic acid lyase Mago-bind PF09282.10 KOS17127.1 - 0.29 11.0 1.1 0.51 10.3 0.1 1.9 2 0 0 2 2 2 0 Mago binding ketoacyl-synt PF00109.26 KOS17128.1 - 7.2e-62 209.2 0.3 1.6e-61 208.1 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 KOS17128.1 - 2.1e-61 207.0 0.2 8.3e-61 205.0 0.1 2.0 2 0 0 2 2 2 1 KR domain Acyl_transf_1 PF00698.21 KOS17128.1 - 1.2e-52 179.4 0.0 2e-52 178.7 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 KOS17128.1 - 3.2e-41 141.5 0.0 1e-40 139.8 0.0 1.8 1 1 1 2 2 2 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 KOS17128.1 - 1.3e-31 109.1 0.3 3.7e-31 107.6 0.3 1.9 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain ADH_zinc_N_2 PF13602.6 KOS17128.1 - 2.7e-18 67.3 0.0 1.9e-17 64.5 0.0 2.3 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Methyltransf_12 PF08242.12 KOS17128.1 - 3.4e-18 66.2 0.0 1.1e-17 64.5 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 KOS17128.1 - 2.2e-17 63.2 0.0 4e-16 59.2 0.1 3.1 3 0 0 3 3 3 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 KOS17128.1 - 5.2e-17 62.3 0.0 1.5e-16 60.9 0.0 1.8 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_23 PF13489.6 KOS17128.1 - 1e-13 51.5 0.0 3.6e-13 49.7 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS17128.1 - 1.2e-11 45.1 0.1 9.8e-11 42.2 0.0 2.6 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 KOS17128.1 - 1.3e-11 44.4 0.5 9e-10 38.3 0.0 2.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS17128.1 - 7.8e-10 38.7 0.4 5.5e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Methyltransf_31 PF13847.6 KOS17128.1 - 6.9e-09 35.7 0.0 1.4e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17128.1 - 2.6e-08 34.4 0.0 1.2e-07 32.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain ADH_N PF08240.12 KOS17128.1 - 6e-07 29.3 0.0 1.6e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Ubie_methyltran PF01209.18 KOS17128.1 - 0.00036 20.0 0.0 0.00072 19.0 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family ACP_syn_III PF08545.10 KOS17128.1 - 0.012 15.4 0.2 0.039 13.8 0.2 1.9 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.23 KOS17128.1 - 0.019 14.3 0.1 0.049 13.0 0.1 1.6 1 0 0 1 1 1 0 Thiolase, N-terminal domain PCMT PF01135.19 KOS17128.1 - 0.034 13.9 0.1 0.084 12.6 0.0 1.6 2 0 0 2 2 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UQ_con PF00179.26 KOS17129.1 - 3.5e-50 169.3 0.0 3.9e-50 169.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TPR_2 PF07719.17 KOS17130.1 - 1.9e-07 30.7 0.0 0.19 11.9 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS17130.1 - 1.5e-06 28.4 0.8 4.8e-05 23.6 0.1 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOS17130.1 - 3.1e-05 23.6 0.0 0.66 9.9 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat UBA PF00627.31 KOS17130.1 - 0.00021 21.1 0.0 0.00063 19.6 0.0 1.9 1 0 0 1 1 1 1 UBA/TS-N domain TPR_4 PF07721.14 KOS17130.1 - 0.0012 19.2 0.2 2.9 8.8 0.0 3.8 2 0 0 2 2 2 2 Tetratricopeptide repeat DnaJ PF00226.31 KOS17130.1 - 0.017 15.3 0.0 0.044 13.9 0.0 1.7 1 0 0 1 1 1 0 DnaJ domain TPR_16 PF13432.6 KOS17130.1 - 2.8 8.7 10.4 0.15 12.8 0.5 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat Hid1 PF12722.7 KOS17131.1 - 6.9 4.7 6.4 8.1 4.4 6.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Voldacs PF03517.13 KOS17132.1 - 1.3e-13 51.3 0.7 1.3e-13 51.3 0.7 2.8 2 1 0 2 2 2 1 Regulator of volume decrease after cellular swelling zf-C3HC4 PF00097.25 KOS17133.1 - 0.46 10.4 18.3 0.2 11.6 7.6 3.3 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17133.1 - 0.57 10.1 20.9 1.1 9.1 9.3 3.7 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF305 PF03713.13 KOS17134.1 - 0.013 15.7 2.6 0.018 15.2 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF305) Dehydratase_hem PF13816.6 KOS17135.1 - 2.2e-102 342.6 0.1 2.5e-102 342.4 0.1 1.0 1 0 0 1 1 1 1 Haem-containing dehydratase DUF4188 PF13826.6 KOS17135.1 - 5.3e-05 23.6 0.8 0.025 14.9 0.3 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4188) PAF-AH_p_II PF03403.13 KOS17136.1 - 6.7e-41 140.1 0.0 7.2e-36 123.5 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KOS17136.1 - 0.0023 16.9 0.0 0.0065 15.4 0.0 1.7 1 1 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 KOS17136.1 - 0.021 14.1 0.0 0.73 9.0 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF346 PF03984.13 KOS17136.1 - 0.12 12.1 0.4 0.31 10.8 0.4 1.7 1 0 0 1 1 1 0 Repeat of unknown function (DUF346) Chlorophyllase PF07224.11 KOS17136.1 - 0.14 11.2 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Glyco_hydro_31 PF01055.26 KOS17137.1 - 1.1e-85 288.5 0.0 1.4e-85 288.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOS17137.1 - 1.2e-14 54.3 0.3 1.2e-13 51.1 0.0 2.7 2 1 1 3 3 3 1 Galactose mutarotase-like DUF5110 PF17137.4 KOS17137.1 - 0.00092 19.4 0.0 0.0024 18.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) MFS_1 PF07690.16 KOS17138.1 - 2.3e-32 112.3 31.4 2.3e-32 112.3 31.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Holin_9 PF16936.5 KOS17138.1 - 0.033 14.4 4.1 5.8 7.2 0.5 3.1 2 0 0 2 2 2 0 Putative holin Homeobox_KN PF05920.11 KOS17139.1 - 3.9e-17 61.8 0.2 9e-17 60.7 0.2 1.7 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KOS17139.1 - 7.4e-09 35.3 0.8 1.5e-08 34.4 0.8 1.5 1 0 0 1 1 1 1 Homeodomain zf-C2H2 PF00096.26 KOS17139.1 - 0.006 17.0 4.4 0.006 17.0 4.4 4.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type Homez PF11569.8 KOS17139.1 - 0.014 14.8 0.4 0.042 13.3 0.0 1.8 1 1 1 2 2 2 0 Homeodomain leucine-zipper encoding, Homez zf-C2H2_4 PF13894.6 KOS17139.1 - 0.026 15.3 4.2 0.026 15.3 4.2 4.6 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 KOS17139.1 - 0.055 13.8 7.5 2.6 8.4 2.2 2.8 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-FCS PF06467.14 KOS17139.1 - 0.13 12.2 0.2 0.13 12.2 0.2 2.6 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif BIR PF00653.21 KOS17139.1 - 1.7 9.4 8.9 5.2 7.8 1.8 3.9 3 1 0 3 3 3 0 Inhibitor of Apoptosis domain zf-Sec23_Sec24 PF04810.15 KOS17139.1 - 2.7 8.1 6.3 7.1 6.8 0.2 3.6 4 0 0 4 4 4 0 Sec23/Sec24 zinc finger PALP PF00291.25 KOS17140.1 - 1.6e-56 191.9 0.4 2.9e-56 191.1 0.4 1.4 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Peptidase_M20 PF01546.28 KOS17140.1 - 2e-31 109.3 0.6 3.9e-31 108.4 0.6 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOS17140.1 - 3.7e-16 59.0 0.1 9.3e-16 57.7 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KOS17140.1 - 9e-05 22.2 0.3 0.00018 21.2 0.3 1.5 1 0 0 1 1 1 1 Peptidase family M28 MFS_1 PF07690.16 KOS17141.1 - 1.8e-34 119.2 28.3 1.8e-34 119.2 28.3 1.4 1 1 1 2 2 2 2 Major Facilitator Superfamily MWFE PF15879.5 KOS17141.1 - 0.0077 16.4 0.1 0.043 14.0 0.1 2.3 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Ig_GlcNase PF18368.1 KOS17142.1 - 2.1e-32 111.4 0.7 7.8e-32 109.6 0.1 2.3 2 0 0 2 2 2 1 Exo-beta-D-glucosaminidase Ig-fold domain Glyco_hydro_2 PF00703.21 KOS17142.1 - 8.8e-14 52.1 0.0 2.2e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Mannosidase_ig PF17786.1 KOS17142.1 - 1.1e-06 29.2 0.0 3.4e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 Mannosidase Ig/CBM-like domain Ig_mannosidase PF17753.1 KOS17142.1 - 0.0027 17.4 0.1 0.0078 15.9 0.1 1.7 1 0 0 1 1 1 1 Ig-fold domain Chorion_2 PF03964.15 KOS17144.1 - 7.5 7.5 9.1 2.1 9.2 4.2 2.2 2 0 0 2 2 2 0 Chorion family 2 Glyco_hydro_12 PF01670.16 KOS17145.1 - 7.4e-22 78.4 0.4 1.4e-20 74.3 0.4 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 12 Glyco_tranf_2_3 PF13641.6 KOS17146.1 - 6.9e-20 71.9 0.0 1.1e-19 71.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 KOS17146.1 - 3.1e-18 66.4 0.2 3.1e-18 66.4 0.2 2.9 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 KOS17146.1 - 5.3e-16 58.9 0.0 8.7e-16 58.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Cellulose_synt PF03552.14 KOS17146.1 - 3.5e-14 52.3 4.1 2.1e-09 36.5 3.9 3.2 1 1 2 3 3 3 2 Cellulose synthase Glyco_transf_21 PF13506.6 KOS17146.1 - 9.1e-14 51.3 0.0 1.5e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Chitin_synth_2 PF03142.15 KOS17146.1 - 4.4e-05 22.3 0.1 0.0029 16.3 0.1 2.4 2 0 0 2 2 2 2 Chitin synthase MgtE PF01769.16 KOS17146.1 - 0.78 10.1 9.3 0.28 11.6 0.7 3.1 3 0 0 3 3 3 0 Divalent cation transporter ABC_tran PF00005.27 KOS17147.1 - 3.3e-51 173.4 0.0 2.5e-30 105.8 0.0 2.6 2 1 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOS17147.1 - 1.4e-48 165.9 27.9 5.5e-29 101.7 9.0 3.4 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 KOS17147.1 - 9.6e-09 35.0 2.9 0.001 18.6 0.0 4.2 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOS17147.1 - 1.9e-05 25.3 0.9 0.033 14.7 0.1 2.4 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOS17147.1 - 2.9e-05 24.5 0.1 0.025 15.0 0.1 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 KOS17147.1 - 0.0003 20.7 3.5 1.4 8.7 0.3 3.5 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOS17147.1 - 0.00082 19.1 0.6 0.95 9.3 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain T2SSE PF00437.20 KOS17147.1 - 0.00099 18.2 0.0 0.11 11.5 0.1 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein MMR_HSR1 PF01926.23 KOS17147.1 - 0.0012 19.0 0.5 0.073 13.2 0.1 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KOS17147.1 - 0.0021 17.4 0.2 1.7 7.9 0.1 2.5 2 0 0 2 2 2 2 Zeta toxin RsgA_GTPase PF03193.16 KOS17147.1 - 0.0024 17.8 0.1 0.9 9.4 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 KOS17147.1 - 0.0043 16.7 0.0 0.36 10.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS17147.1 - 0.02 15.2 0.6 20 5.5 0.1 3.3 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 KOS17147.1 - 0.046 14.1 0.4 37 4.7 0.1 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOS17147.1 - 0.071 12.8 1.7 17 5.1 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KOS17147.1 - 0.11 12.0 0.2 17 4.9 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 KOS17147.1 - 0.24 11.5 1.8 1 9.4 0.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_24 PF13479.6 KOS17147.1 - 0.82 9.4 3.5 4.2 7.1 0.0 3.1 4 0 0 4 4 4 0 AAA domain SecY PF00344.20 KOS17148.1 - 8.6e-72 242.0 9.3 1.1e-71 241.6 9.3 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 KOS17148.1 - 3.1e-17 62.1 0.2 1e-16 60.5 0.2 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p DUF3817 PF12823.7 KOS17148.1 - 0.096 13.5 0.8 6.6 7.6 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3817) IPPT PF01715.17 KOS17149.1 - 2.4e-58 197.6 0.0 3.4e-58 197.2 0.0 1.1 1 0 0 1 1 1 1 IPP transferase IPT PF01745.16 KOS17149.1 - 9.9e-06 25.1 0.0 4.1e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Isopentenyl transferase AAA_33 PF13671.6 KOS17149.1 - 0.00034 20.8 0.3 0.0034 17.5 0.3 2.4 1 1 0 1 1 1 1 AAA domain zf-C2H2_jaz PF12171.8 KOS17149.1 - 0.0058 16.9 0.1 0.0095 16.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding AAA_16 PF13191.6 KOS17149.1 - 0.02 15.3 3.6 0.087 13.2 3.1 2.6 1 1 0 1 1 1 0 AAA ATPase domain Hpr_kinase_C PF07475.12 KOS17149.1 - 0.04 13.4 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain AAA_28 PF13521.6 KOS17149.1 - 0.053 13.8 0.0 0.18 12.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 KOS17149.1 - 0.061 13.4 0.1 14 5.8 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase AAA_22 PF13401.6 KOS17149.1 - 0.084 13.2 0.0 0.98 9.7 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 KOS17149.1 - 0.093 13.3 0.2 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain zf-C2H2_2 PF12756.7 KOS17149.1 - 0.098 13.0 0.1 0.17 12.2 0.1 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) AAA_5 PF07728.14 KOS17149.1 - 0.12 12.3 0.0 0.3 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) zf-met PF12874.7 KOS17149.1 - 0.15 12.5 0.4 0.26 11.8 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KOS17149.1 - 0.19 12.7 0.3 0.37 11.8 0.3 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger Fungal_trans PF04082.18 KOS17150.1 - 3.4e-15 55.8 0.0 5.3e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS17150.1 - 1.3e-06 28.5 10.4 2.2e-06 27.7 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PspB PF06667.12 KOS17152.1 - 0.061 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Phage shock protein B ADH_N PF08240.12 KOS17153.1 - 5.5e-30 103.5 0.1 1.1e-29 102.5 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS17153.1 - 6.4e-13 48.8 0.0 1e-12 48.1 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS17153.1 - 0.00031 21.8 0.0 0.00084 20.4 0.0 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS17153.1 - 0.00089 18.8 0.3 0.0022 17.5 0.3 1.6 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_N_assoc PF13823.6 KOS17153.1 - 0.0017 18.2 0.0 0.0043 16.9 0.0 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated AlaDh_PNT_C PF01262.21 KOS17153.1 - 0.058 12.7 0.8 0.1 11.9 0.8 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain RhoGAP PF00620.27 KOS17154.1 - 4.3e-10 39.6 0.0 8.3e-10 38.7 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain XPC-binding PF09280.11 KOS17155.1 - 5.4e-25 86.9 12.4 9.3e-25 86.1 12.4 1.4 1 0 0 1 1 1 1 XPC-binding domain UBA PF00627.31 KOS17155.1 - 4.4e-23 80.8 8.7 6.9e-12 45.0 0.4 2.7 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 KOS17155.1 - 6.1e-19 67.5 0.2 1e-18 66.8 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOS17155.1 - 1.8e-06 27.6 0.3 3.2e-06 26.9 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Clathrin_H_link PF13838.6 KOS17155.1 - 0.024 14.6 0.4 0.11 12.5 0.4 2.2 1 0 0 1 1 1 0 Clathrin-H-link Rad60-SLD_2 PF13881.6 KOS17155.1 - 0.05 13.7 0.0 0.097 12.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like SOG2 PF10428.9 KOS17155.1 - 0.083 12.1 4.4 0.1 11.8 4.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein UBA_3 PF09288.10 KOS17155.1 - 0.1 12.4 0.0 7.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Ubiquitin_5 PF18037.1 KOS17155.1 - 0.16 12.4 0.0 0.28 11.6 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain TFIIA PF03153.13 KOS17155.1 - 3.6 7.5 11.0 5.9 6.8 11.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Myb_DNA-bind_7 PF15963.5 KOS17156.1 - 1.5e-22 79.3 0.3 1.5e-22 79.3 0.3 2.2 1 1 1 2 2 2 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 KOS17156.1 - 4.6e-06 26.7 0.0 8.3e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS17156.1 - 0.00095 19.4 0.1 0.0022 18.2 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF1996 PF09362.10 KOS17157.1 - 4.5e-61 206.8 0.6 6.2e-61 206.4 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) WSC PF01822.19 KOS17157.1 - 1.5e-19 69.9 5.0 1.5e-19 69.9 5.0 2.1 2 0 0 2 2 2 1 WSC domain Opiods_neuropep PF01160.18 KOS17157.1 - 0.27 11.4 1.8 1.4 9.1 0.5 2.5 2 0 0 2 2 2 0 Vertebrate endogenous opioids neuropeptide Methyltr_RsmB-F PF01189.17 KOS17158.1 - 1.1e-14 54.6 0.0 1.6e-09 37.7 0.0 2.5 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F NOA36 PF06524.12 KOS17158.1 - 0.12 11.7 14.9 0.18 11.1 14.9 1.2 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 KOS17158.1 - 0.14 11.6 7.8 0.27 10.6 7.8 1.5 1 0 0 1 1 1 0 SDA1 TFB6 PF17110.5 KOS17158.1 - 1.6 8.5 5.7 12 5.6 5.7 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF1645 PF07816.11 KOS17158.1 - 1.7 9.2 5.4 0.33 11.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) Sigma70_ner PF04546.13 KOS17158.1 - 5.1 6.9 12.4 11 5.8 12.4 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region MFS_1 PF07690.16 KOS17159.1 - 6.6e-38 130.5 52.2 9.1e-38 130.1 47.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS17159.1 - 7.7e-10 38.2 9.6 7.7e-10 38.2 9.6 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter BRE1 PF08647.11 KOS17161.1 - 5.6e-28 96.9 11.0 5.6e-28 96.9 11.0 7.0 3 2 3 6 6 5 2 BRE1 E3 ubiquitin ligase Prok-RING_4 PF14447.6 KOS17161.1 - 2e-08 33.9 6.8 3.4e-08 33.2 6.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOS17161.1 - 3.3e-08 33.3 7.9 5e-08 32.7 7.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS17161.1 - 6e-08 32.4 10.3 1.1e-07 31.6 10.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17161.1 - 6.6e-07 29.1 9.0 1.1e-06 28.3 9.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS17161.1 - 3.9e-06 26.7 9.8 6.5e-06 26.0 9.8 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOS17161.1 - 6.3e-06 26.1 5.7 1.2e-05 25.2 5.7 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOS17161.1 - 3.4e-05 24.1 8.3 5.6e-05 23.4 8.3 1.4 1 0 0 1 1 1 1 Ring finger domain FAM184 PF15665.5 KOS17161.1 - 0.00019 21.3 25.9 0.00019 21.3 25.9 5.0 3 2 2 5 5 3 1 Family with sequence similarity 184, A and B KASH_CCD PF14662.6 KOS17161.1 - 0.0014 18.5 13.9 0.0014 18.5 13.9 4.6 3 1 0 4 4 4 2 Coiled-coil region of CCDC155 or KASH JIP_LZII PF16471.5 KOS17161.1 - 0.0022 18.1 1.2 0.0022 18.1 1.2 7.6 6 1 1 7 7 6 2 JNK-interacting protein leucine zipper II DivIC PF04977.15 KOS17161.1 - 0.0026 17.5 0.5 0.0026 17.5 0.5 10.1 6 1 5 12 12 10 2 Septum formation initiator zf-C3HC4_4 PF15227.6 KOS17161.1 - 0.043 14.0 6.4 0.084 13.0 6.4 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING bZIP_1 PF00170.21 KOS17161.1 - 0.048 13.8 1.0 0.048 13.8 1.0 10.4 4 3 9 13 13 13 0 bZIP transcription factor zf-rbx1 PF12678.7 KOS17161.1 - 0.081 13.2 4.9 0.26 11.6 4.9 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 KOS17161.1 - 0.14 12.0 6.4 1.3 8.9 7.4 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 KOS17161.1 - 0.33 10.8 2.3 0.67 9.9 2.3 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FYVE PF01363.21 KOS17161.1 - 2.2 8.5 11.4 26 5.1 11.2 2.3 1 1 1 2 2 2 0 FYVE zinc finger VGPC1_C PF16799.5 KOS17161.1 - 4 7.5 9.6 3.7 7.6 0.8 3.6 3 0 0 3 3 3 0 C-terminal membrane-localisation domain of ion-channel, VCN1 EFG_II PF14492.6 KOS17161.1 - 4.1 7.6 5.7 1.4 9.1 0.1 3.1 3 0 0 3 3 3 0 Elongation Factor G, domain II TSC22 PF01166.18 KOS17161.1 - 4.6 7.6 25.8 2 8.8 0.7 7.1 6 1 1 7 7 7 0 TSC-22/dip/bun family CCDC92 PF14916.6 KOS17161.1 - 5.4 6.9 13.1 0.32 10.8 0.1 4.4 4 1 1 5 5 5 0 Coiled-coil domain of unknown function SARAF PF06682.12 KOS17162.1 - 2.8e-86 290.2 0.1 5.6e-86 289.2 0.1 1.4 1 1 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis PSI_integrin PF17205.3 KOS17163.1 - 0.15 11.8 1.8 0.22 11.3 0.3 2.0 2 0 0 2 2 2 0 Integrin plexin domain TMEM37 PF15108.6 KOS17164.1 - 0.016 15.1 1.1 0.02 14.8 1.1 1.1 1 0 0 1 1 1 0 Voltage-dependent calcium channel gamma-like subunit protein family SNF5 PF04855.12 KOS17165.1 - 4.8e-65 219.7 0.1 6.5e-64 216.0 0.1 2.2 1 1 0 1 1 1 1 SNF5 / SMARCB1 / INI1 Peptidase_M24 PF00557.24 KOS17166.1 - 2.7e-07 30.5 0.0 4.4e-07 29.8 0.0 1.4 1 1 0 1 1 1 1 Metallopeptidase family M24 SapB_1 PF05184.15 KOS17166.1 - 0.39 10.8 2.2 0.57 10.3 0.1 2.4 2 0 0 2 2 2 0 Saposin-like type B, region 1 PUF PF00806.19 KOS17167.1 - 1.7e-27 93.5 0.0 6.9e-05 22.3 0.0 5.8 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat RRM_1 PF00076.22 KOS17167.1 - 2.2e-13 49.8 0.0 4.2e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 KOS17168.1 - 2.2e-57 194.4 2.5 4e-56 190.3 2.5 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17168.1 - 3e-43 148.0 0.1 1.2e-42 146.1 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KOS17168.1 - 3.2e-24 85.0 0.4 1.2e-23 83.2 0.0 2.3 2 0 0 2 2 2 1 P21-Rho-binding domain PH_11 PF15413.6 KOS17168.1 - 2.1e-06 28.1 0.2 6.9e-06 26.4 0.2 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KOS17168.1 - 0.00076 20.0 0.0 0.0016 18.9 0.0 1.6 1 0 0 1 1 1 1 PH domain Pkinase_fungal PF17667.1 KOS17168.1 - 0.0011 17.9 0.6 0.003 16.4 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOS17168.1 - 0.0019 17.6 0.0 0.0032 16.8 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS17168.1 - 0.037 14.0 1.5 0.13 12.2 0.0 2.5 3 0 0 3 3 3 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS17168.1 - 0.14 11.0 1.0 0.27 10.1 0.0 1.7 2 0 0 2 2 2 0 Haspin like kinase domain U1snRNP70_N PF12220.8 KOS17168.1 - 4 8.1 11.2 0.088 13.5 0.8 2.9 2 1 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal BUD22 PF09073.10 KOS17169.1 - 0.0027 17.1 10.7 0.0027 17.1 10.7 4.0 2 1 0 2 2 2 1 BUD22 SDA1 PF05285.12 KOS17169.1 - 0.11 11.9 41.6 0.25 10.7 11.0 3.6 2 1 2 4 4 4 0 SDA1 PHD PF00628.29 KOS17170.1 - 1.1e-15 57.3 19.8 6.5e-09 35.5 10.3 2.4 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 KOS17170.1 - 0.025 14.2 8.3 0.55 9.8 2.8 2.3 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain C1_1 PF00130.22 KOS17170.1 - 0.044 13.7 16.7 0.097 12.6 1.6 2.7 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 KOS17170.1 - 0.089 13.1 0.6 0.089 13.1 0.6 2.8 3 0 0 3 3 3 0 C1 domain Zf_RING PF16744.5 KOS17170.1 - 1.3 9.2 12.9 1.4 9.1 0.7 2.5 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_2 PF13831.6 KOS17170.1 - 1.4 8.5 19.4 0.044 13.3 5.3 3.5 4 0 0 4 4 4 0 PHD-finger Prok-RING_1 PF14446.6 KOS17170.1 - 2.6 8.0 18.6 3.5 7.6 6.8 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Peptidase_M76 PF09768.9 KOS17171.1 - 3.7e-69 231.9 1.2 4.5e-69 231.6 1.2 1.1 1 0 0 1 1 1 1 Peptidase M76 family SprT-like PF10263.9 KOS17171.1 - 0.0065 16.3 1.6 0.011 15.6 0.7 1.8 1 1 0 2 2 2 1 SprT-like family Peptidase_M91 PF14891.6 KOS17171.1 - 0.052 13.9 0.1 0.074 13.4 0.1 1.2 1 0 0 1 1 1 0 Effector protein Pkinase PF00069.25 KOS17172.1 - 2.1e-70 237.1 0.0 2.6e-70 236.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17172.1 - 3.1e-43 147.9 0.0 4.1e-43 147.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17172.1 - 3.6e-06 26.5 0.0 6.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOS17172.1 - 0.0005 19.5 0.1 0.00076 18.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOS17172.1 - 0.031 13.9 0.0 0.053 13.1 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 KOS17172.1 - 0.033 13.2 0.1 0.047 12.6 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 KOS17172.1 - 0.096 12.6 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KOS17172.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 KOS17172.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.6 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 HGTP_anticodon PF03129.20 KOS17173.1 - 3.3e-22 78.5 1.0 1.3e-21 76.5 0.1 2.4 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOS17173.1 - 4e-08 33.4 0.0 7.9e-07 29.2 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) AA_kinase PF00696.28 KOS17174.1 - 6e-40 137.3 0.8 7.6e-40 137.0 0.8 1.1 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 KOS17174.1 - 1.6e-15 56.8 0.4 8.6e-15 54.5 0.0 2.2 2 0 0 2 2 2 1 PUA domain HEAT_2 PF13646.6 KOS17175.1 - 2.1e-05 24.9 0.1 0.1 13.0 0.0 4.3 3 1 1 4 4 4 3 HEAT repeats HEAT PF02985.22 KOS17175.1 - 0.00025 21.1 1.6 0.36 11.2 0.0 5.0 5 0 0 5 5 5 1 HEAT repeat HEAT_EZ PF13513.6 KOS17175.1 - 0.033 14.7 3.0 0.14 12.7 0.0 3.7 4 1 1 5 5 5 0 HEAT-like repeat Cnd1 PF12717.7 KOS17175.1 - 0.075 13.1 0.0 12 5.9 0.0 4.0 5 0 0 5 5 5 0 non-SMC mitotic condensation complex subunit 1 BUD22 PF09073.10 KOS17175.1 - 0.69 9.2 29.6 3.3 6.9 27.9 2.4 2 0 0 2 2 2 0 BUD22 CDC37_N PF03234.14 KOS17176.1 - 8.5e-47 159.3 3.3 3.7e-46 157.2 0.1 3.1 3 0 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 KOS17176.1 - 4.6e-37 126.5 0.6 1e-36 125.4 0.6 1.6 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 KOS17176.1 - 1.3e-32 111.9 3.2 1.3e-32 111.9 3.2 2.5 2 0 0 2 2 2 1 Cdc37 C terminal domain Striatin PF08232.12 KOS17176.1 - 0.11 13.1 0.2 0.11 13.1 0.2 2.9 2 1 1 3 3 3 0 Striatin family CCDC-167 PF15188.6 KOS17176.1 - 0.8 10.1 9.6 0.068 13.5 3.4 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 DUF3535 PF12054.8 KOS17177.1 - 2.8e-122 409.1 0.0 1e-121 407.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 KOS17177.1 - 6.5e-66 222.4 0.0 1.6e-65 221.1 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS17177.1 - 4.2e-20 72.1 0.0 2e-19 70.0 0.0 2.2 2 0 0 2 2 1 1 Helicase conserved C-terminal domain HEAT PF02985.22 KOS17177.1 - 1.4e-15 56.1 4.5 0.018 15.2 0.0 8.3 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 KOS17177.1 - 8.3e-08 32.5 0.7 0.0052 17.1 0.1 5.6 5 0 0 5 5 5 1 HEAT repeats Vac14_Fab1_bd PF12755.7 KOS17177.1 - 9.9e-06 26.1 0.1 0.49 11.0 0.0 4.1 3 1 0 4 4 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 KOS17177.1 - 0.0003 21.2 4.2 12 6.5 0.0 6.6 7 0 0 7 7 7 1 HEAT-like repeat CLASP_N PF12348.8 KOS17177.1 - 0.016 14.8 0.6 0.62 9.6 0.1 3.3 3 2 0 3 3 3 0 CLASP N terminal P63C PF10546.9 KOS17177.1 - 0.09 13.4 0.0 0.3 11.7 0.0 1.9 1 0 0 1 1 1 0 P63C domain UME PF08064.13 KOS17177.1 - 0.34 10.8 5.8 67 3.5 0.2 4.7 3 2 1 4 4 4 0 UME (NUC010) domain Ribosomal_60s PF00428.19 KOS17177.1 - 2.1 9.0 9.8 10 6.8 9.8 2.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein Fungal_trans PF04082.18 KOS17178.1 - 2e-05 23.8 0.0 4e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Peptidase_C58 PF03543.14 KOS17178.1 - 0.018 14.8 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen GCV_H PF01597.19 KOS17180.1 - 2.4e-35 121.1 0.1 2.9e-35 120.8 0.1 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein Ras PF00071.22 KOS17181.1 - 1.3e-31 109.4 0.2 1.6e-31 109.1 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS17181.1 - 6e-24 84.6 0.1 1.1e-23 83.7 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS17181.1 - 1.7e-06 27.6 0.1 2.3e-06 27.2 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOS17181.1 - 0.0004 19.8 0.2 0.00053 19.4 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DLIC PF05783.11 KOS17181.1 - 0.0039 16.1 0.1 0.37 9.6 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) PAPS_reduct PF01507.19 KOS17182.1 - 7.1e-29 101.1 0.0 1.8e-21 76.9 0.0 2.1 1 1 1 2 2 2 2 Phosphoadenosine phosphosulfate reductase family PLDc_2 PF13091.6 KOS17183.1 - 2.7e-16 59.7 0.0 1.4e-09 37.9 0.0 2.8 3 0 0 3 3 3 2 PLD-like domain PLDc PF00614.22 KOS17183.1 - 1.9e-08 34.1 0.7 0.00026 21.0 0.1 2.8 2 1 0 2 2 2 2 Phospholipase D Active site motif DUF3306 PF11748.8 KOS17183.1 - 0.033 15.1 0.8 0.085 13.7 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) SPAN PF02510.14 KOS17183.1 - 3.9 6.6 11.3 6.1 5.9 11.3 1.2 1 0 0 1 1 1 0 Surface presentation of antigens protein NDUFA12 PF05071.16 KOS17184.1 - 2.3e-27 95.7 0.4 2.9e-27 95.3 0.4 1.1 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 AidB_N PF18158.1 KOS17184.1 - 0.018 14.9 0.2 0.25 11.3 0.0 2.0 2 0 0 2 2 2 0 Adaptive response protein AidB N-terminal domain PNTB PF02233.16 KOS17185.1 - 5.5e-168 559.6 24.1 5.5e-168 559.6 24.1 2.2 2 0 0 2 2 2 1 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 KOS17185.1 - 4.7e-56 189.5 3.3 1e-55 188.3 0.7 2.8 2 1 1 3 3 3 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 KOS17185.1 - 2.3e-47 160.7 0.5 5.6e-47 159.5 0.1 1.9 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 KOS17185.1 - 4e-30 104.1 3.4 4e-30 104.1 3.4 5.8 5 1 1 6 6 5 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 KOS17185.1 - 0.0042 16.5 1.3 0.23 10.8 0.1 2.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 KOS17185.1 - 0.0053 16.0 0.8 0.037 13.3 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ADH_zinc_N PF00107.26 KOS17185.1 - 0.006 16.6 0.1 0.043 13.8 0.1 2.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_8 PF13450.6 KOS17185.1 - 0.011 15.9 0.3 0.18 12.0 0.3 3.0 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain TPP_enzyme_M PF00205.22 KOS17185.1 - 0.031 14.0 0.2 0.26 11.0 0.2 2.5 1 1 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain CP_ATPgrasp_1 PF04174.13 KOS17185.1 - 0.032 13.3 0.5 2.7 6.9 0.0 2.5 2 0 0 2 2 2 0 A circularly permuted ATPgrasp GIDA PF01134.22 KOS17185.1 - 0.061 12.4 0.8 0.12 11.4 0.8 1.5 1 0 0 1 1 1 0 Glucose inhibited division protein A CP_ATPgrasp_2 PF14403.6 KOS17185.1 - 0.25 10.2 1.6 5.2 5.9 0.0 2.9 3 0 0 3 3 3 0 Circularly permuted ATP-grasp type 2 Tau95 PF09734.9 KOS17186.1 - 3e-40 138.3 0.2 5e-40 137.5 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 KOS17186.1 - 3.5e-35 121.0 0.0 6.1e-35 120.2 0.0 1.4 1 0 0 1 1 1 1 Tau95 Triple barrel domain TFIIA PF03153.13 KOS17186.1 - 0.026 14.5 15.8 0.049 13.6 15.8 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_3_Rpc31 PF11705.8 KOS17186.1 - 0.067 13.4 19.6 0.19 11.9 19.6 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Cwf_Cwc_15 PF04889.12 KOS17186.1 - 0.24 11.1 14.0 0.5 10.1 14.0 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 KOS17186.1 - 8.8 4.4 18.4 12 3.9 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family B56 PF01603.20 KOS17187.1 - 2.1e-193 643.0 2.8 2.4e-193 642.8 2.8 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Sec7_N PF12783.7 KOS17187.1 - 6.3e-05 22.9 0.7 0.31 10.9 0.3 2.4 2 0 0 2 2 2 2 Guanine nucleotide exchange factor in Golgi transport N-terminal CTD_bind PF04818.13 KOS17188.1 - 5.8e-13 49.5 0.0 1.5e-12 48.1 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase II-binding domain. SRP-alpha_N PF04086.13 KOS17188.1 - 0.052 13.5 10.2 0.075 13.0 10.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4748 PF15932.5 KOS17189.1 - 1.2e-24 85.8 0.6 1.7e-24 85.3 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4748) ANAPC_CDC26 PF10471.9 KOS17189.1 - 0.047 14.5 4.0 0.091 13.6 4.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Exo_endo_phos PF03372.23 KOS17190.1 - 3.7e-10 39.7 0.0 1.1e-09 38.1 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 KOS17190.1 - 0.32 11.9 1.7 4.9 8.2 0.1 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat CRAL_TRIO PF00650.20 KOS17191.1 - 9.1e-39 132.7 0.1 9.1e-39 132.7 0.1 1.7 2 1 1 3 3 3 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOS17191.1 - 1.6e-12 47.4 0.1 1.6e-12 47.4 0.1 2.3 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain COMPASS-Shg1 PF05205.12 KOS17191.1 - 7.6 7.3 8.9 51 4.7 9.0 2.1 1 1 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component shg1 BCS1_N PF08740.11 KOS17192.1 - 2.2e-44 151.7 0.3 3.5e-44 151.0 0.3 1.3 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KOS17192.1 - 2.4e-17 63.6 0.0 3.7e-08 33.9 0.0 2.8 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOS17192.1 - 0.0084 15.9 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS17192.1 - 0.11 12.9 0.1 0.23 11.8 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 KOS17192.1 - 0.12 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOS17192.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 KaiC TRAPP PF04051.16 KOS17193.1 - 1.2e-43 148.4 0.0 1.4e-43 148.1 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Apc13p PF05839.11 KOS17194.1 - 8e-35 118.9 0.1 9.2e-35 118.7 0.1 1.0 1 0 0 1 1 1 1 Apc13p protein LRR_6 PF13516.6 KOS17195.1 - 7.5e-12 44.3 13.0 0.0043 17.0 0.0 7.8 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 KOS17195.1 - 4.3e-08 33.3 15.9 0.043 14.3 0.1 6.0 5 2 0 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOS17195.1 - 0.00049 20.3 22.8 2.5 9.0 0.1 7.7 8 1 0 8 8 8 4 Leucine Rich Repeat His_Phos_1 PF00300.22 KOS17196.1 - 4e-18 65.8 0.1 1.4e-09 38.0 0.0 2.2 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Tecti-min-caps PF09300.10 KOS17196.1 - 0.058 13.5 0.3 1.7 8.8 0.0 2.4 2 0 0 2 2 2 0 Tectiviridae, minor capsid zinc_ribbon_16 PF17034.5 KOS17197.1 - 1.8e-18 66.9 6.0 3.5e-18 66.0 6.0 1.5 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 KOS17197.1 - 7.6e-07 28.7 4.3 7.6e-07 28.7 4.3 2.1 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type DEAD PF00270.29 KOS17198.1 - 9.5e-30 103.7 0.0 1.6e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17198.1 - 4.2e-20 72.1 0.0 2.8e-19 69.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17198.1 - 0.00013 22.1 0.0 0.00041 20.4 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Iwr1 PF08574.10 KOS17199.1 - 2.1e-15 57.5 6.9 2.1e-15 57.5 6.9 2.9 2 1 0 2 2 2 1 Transcription factor Iwr1 hNIFK_binding PF12196.8 KOS17200.1 - 0.043 13.3 0.2 0.27 10.8 0.2 2.4 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK TIP41 PF04176.13 KOS17201.1 - 7.4e-64 214.4 1.4 1.3e-63 213.6 1.4 1.4 1 1 0 1 1 1 1 TIP41-like family BSP_II PF05432.11 KOS17201.1 - 0.0038 17.0 5.1 0.0058 16.4 5.1 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) FAM176 PF14851.6 KOS17201.1 - 0.026 14.2 2.2 0.048 13.3 2.2 1.4 1 0 0 1 1 1 0 FAM176 family Myc_N PF01056.18 KOS17201.1 - 0.036 14.0 0.9 0.046 13.6 0.9 1.2 1 0 0 1 1 1 0 Myc amino-terminal region NOA36 PF06524.12 KOS17201.1 - 2.6 7.3 5.3 3.6 6.8 5.3 1.1 1 0 0 1 1 1 0 NOA36 protein Trp_DMAT PF11991.8 KOS17202.1 - 0.059 12.8 1.1 0.087 12.2 0.5 1.6 2 0 0 2 2 2 0 Tryptophan dimethylallyltransferase VSG_B PF13206.6 KOS17202.1 - 0.085 12.1 1.3 0.14 11.4 1.3 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain Pex26 PF07163.12 KOS17202.1 - 0.097 12.0 9.8 0.54 9.5 9.8 2.0 1 1 0 1 1 1 0 Pex26 protein GAGA_bind PF06217.12 KOS17202.1 - 0.7 10.1 5.1 1 9.6 5.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family CDC45 PF02724.14 KOS17202.1 - 1.3 7.3 11.5 1.9 6.7 11.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Rrn6 PF10214.9 KOS17202.1 - 8.3 4.8 16.5 0.26 9.8 10.6 1.5 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Haspin_kinase PF12330.8 KOS17203.1 - 2.3e-30 105.8 0.0 3.4e-30 105.2 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Thiamine_BP PF01910.17 KOS17204.1 - 3.1e-31 107.1 0.1 3.5e-31 106.9 0.1 1.0 1 0 0 1 1 1 1 Thiamine-binding protein Arm PF00514.23 KOS17205.1 - 4.3e-75 245.7 34.6 1.5e-13 50.3 0.1 11.1 11 0 0 11 11 11 10 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOS17205.1 - 8.3e-20 70.9 10.8 0.00012 22.5 0.6 7.7 6 1 2 8 8 8 4 HEAT-like repeat HEAT_2 PF13646.6 KOS17205.1 - 8.4e-18 64.6 9.4 7e-05 23.1 0.1 6.6 4 3 3 8 8 7 5 HEAT repeats HEAT PF02985.22 KOS17205.1 - 7e-15 53.9 16.7 0.068 13.5 0.3 8.8 10 0 0 10 10 9 5 HEAT repeat Adaptin_N PF01602.20 KOS17205.1 - 4.2e-11 42.1 9.8 3.5e-07 29.2 0.5 2.6 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 KOS17205.1 - 1.3e-10 41.2 6.7 2.1e-07 30.7 2.3 2.6 1 1 1 2 2 2 2 Armadillo-like KAP PF05804.12 KOS17205.1 - 1.5e-09 36.7 0.2 3.2e-09 35.5 0.2 1.5 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_N PF03224.14 KOS17205.1 - 7e-09 35.4 1.9 4.7e-05 22.8 1.0 3.4 2 1 1 3 3 3 2 V-ATPase subunit H DUF3361 PF11841.8 KOS17205.1 - 5.7e-05 23.1 7.2 0.41 10.6 0.1 4.1 2 1 2 4 4 4 3 Domain of unknown function (DUF3361) V-ATPase_H_C PF11698.8 KOS17205.1 - 9.5e-05 22.5 0.9 22 5.2 0.1 4.8 2 1 5 7 7 7 0 V-ATPase subunit H DUF5578 PF17741.1 KOS17205.1 - 0.00027 20.4 5.9 1.4 8.2 0.3 4.7 1 1 3 5 5 5 2 Family of unknown function (DUF5578) Cnd1 PF12717.7 KOS17205.1 - 0.0013 18.8 2.8 0.034 14.2 0.4 5.0 2 1 4 7 7 7 2 non-SMC mitotic condensation complex subunit 1 UNC45-central PF11701.8 KOS17205.1 - 0.0089 16.0 1.6 1.8 8.5 0.1 3.5 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central HEAT_PBS PF03130.16 KOS17205.1 - 0.035 14.8 9.2 34 5.5 0.2 7.0 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 KOS17205.1 - 0.038 14.6 0.2 4.3 8.0 0.0 3.5 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region Atx10homo_assoc PF09759.9 KOS17205.1 - 0.21 11.6 6.9 4.2 7.5 0.1 4.3 3 2 1 4 4 4 0 Spinocerebellar ataxia type 10 protein domain Peptidase_S26 PF10502.9 KOS17206.1 - 5.3e-06 26.3 0.0 0.0016 18.3 0.0 2.7 2 1 0 2 2 2 2 Signal peptidase, peptidase S26 Peptidase_S24 PF00717.23 KOS17206.1 - 0.00028 20.8 0.0 0.00045 20.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase S24-like adh_short_C2 PF13561.6 KOS17207.1 - 1.8e-58 197.9 0.5 2.1e-58 197.7 0.5 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS17207.1 - 1.5e-43 148.6 0.6 1.8e-43 148.2 0.6 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS17207.1 - 2e-10 40.9 0.4 3.8e-10 40.0 0.4 1.4 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS17207.1 - 3.1e-05 23.6 0.0 4.6e-05 23.0 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 KOS17207.1 - 0.0022 17.4 0.0 0.0033 16.9 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 KOS17207.1 - 0.069 13.0 1.0 0.11 12.3 1.0 1.4 1 0 0 1 1 1 0 NAD(P)H-binding Transketolase_C PF02780.20 KOS17207.1 - 0.12 12.2 0.2 0.46 10.4 0.2 1.9 2 1 0 2 2 2 0 Transketolase, C-terminal domain Ribosomal_S11 PF00411.19 KOS17207.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.3 2 2 0 2 2 2 0 Ribosomal protein S11 LSM PF01423.22 KOS17208.1 - 1.7e-18 66.1 0.0 2.3e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain Ribosomal_L4 PF00573.22 KOS17209.1 - 3.5e-44 150.8 0.0 4.7e-44 150.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family PBP PF01161.20 KOS17210.1 - 5.1e-07 30.1 0.0 8.6e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Rep_fac-A_3 PF08661.11 KOS17211.1 - 4e-12 46.4 0.0 6.1e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Replication factor A protein 3 Tropomyosin_1 PF12718.7 KOS17212.1 - 0.011 15.9 0.7 0.021 15.0 0.7 1.4 1 0 0 1 1 1 0 Tropomyosin like ADIP PF11559.8 KOS17212.1 - 0.034 14.2 2.5 0.22 11.6 2.0 2.2 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding PKcGMP_CC PF16808.5 KOS17212.1 - 0.25 11.2 3.1 0.62 10.0 3.1 1.6 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase MAD PF05557.13 KOS17212.1 - 0.36 9.2 4.7 0.87 7.9 4.7 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein ATG16 PF08614.11 KOS17212.1 - 4.1 7.6 8.4 4.7 7.4 1.1 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CorA PF01544.18 KOS17213.1 - 7.6e-10 38.6 8.2 7.9e-10 38.5 4.0 2.2 1 1 1 2 2 2 1 CorA-like Mg2+ transporter protein ssDNA-exonuc_C PF10141.9 KOS17213.1 - 0.071 12.8 0.9 0.26 10.9 0.9 1.8 1 1 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain NBP1 PF08537.10 KOS17213.1 - 0.87 8.9 7.9 5.6 6.3 7.4 1.8 1 1 1 2 2 2 0 Fungal Nap binding protein NBP1 DUF676 PF05057.14 KOS17214.1 - 1.1e-05 25.1 0.0 2.1e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 KOS17214.1 - 0.091 12.5 0.0 0.18 11.5 0.0 1.5 1 1 0 1 1 1 0 PGAP1-like protein CDC45 PF02724.14 KOS17214.1 - 0.14 10.5 2.6 1.3 7.2 2.8 2.0 2 0 0 2 2 2 0 CDC45-like protein Ribonucleas_3_3 PF14622.6 KOS17215.1 - 8.9e-23 80.9 0.0 1.5e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 Ribonuclease-III-like Mucin PF01456.17 KOS17215.1 - 0.48 10.4 10.6 0.7 9.9 10.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein RseC_MucC PF04246.12 KOS17216.1 - 3.1 7.8 6.9 0.32 11.0 0.4 2.5 3 0 0 3 3 3 0 Positive regulator of sigma(E), RseC/MucC IPP-2 PF04979.14 KOS17218.1 - 2.1e-21 77.1 7.8 2.1e-21 77.1 7.8 2.2 2 1 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) Cupin_2 PF07883.11 KOS17219.1 - 0.045 13.5 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 Cupin domain MTH865 PF07747.11 KOS17219.1 - 0.058 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 MTH865-like family Cupin_3 PF05899.12 KOS17219.1 - 0.072 12.8 0.0 0.92 9.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) Ribosomal_L27 PF01016.19 KOS17220.1 - 3.7e-26 91.0 0.9 5.6e-26 90.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal L27 protein Cutinase PF01083.22 KOS17221.1 - 7.4e-47 159.6 3.5 9e-47 159.3 3.5 1.1 1 0 0 1 1 1 1 Cutinase PE-PPE PF08237.11 KOS17221.1 - 7e-05 22.5 0.1 0.00011 21.9 0.1 1.3 1 0 0 1 1 1 1 PE-PPE domain Thioesterase PF00975.20 KOS17221.1 - 0.0016 18.6 0.0 0.0027 17.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain VirJ PF06057.11 KOS17221.1 - 0.003 17.5 0.0 0.0043 17.0 0.0 1.2 1 0 0 1 1 1 1 Bacterial virulence protein (VirJ) Abhydrolase_2 PF02230.16 KOS17221.1 - 0.0077 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF2974 PF11187.8 KOS17221.1 - 0.05 13.2 0.1 0.076 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_1 PF00561.20 KOS17221.1 - 0.053 13.2 0.1 0.072 12.7 0.1 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS17221.1 - 0.45 11.1 3.5 0.57 10.7 2.1 1.8 1 1 1 2 2 2 0 Alpha/beta hydrolase family HAT_KAT11 PF08214.11 KOS17222.1 - 1.1e-83 281.5 0.0 1.8e-83 280.8 0.0 1.3 1 1 0 1 1 1 1 Histone acetylation protein PLU-1 PF08429.11 KOS17223.1 - 5e-46 157.4 11.2 1.8e-19 70.1 3.2 4.1 1 1 2 3 3 3 3 PLU-1-like protein JmjC PF02373.22 KOS17223.1 - 1.2e-43 148.2 0.3 2.7e-43 147.0 0.3 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-C5HC2 PF02928.16 KOS17223.1 - 8.8e-09 35.6 0.7 1.9e-08 34.6 0.7 1.6 1 0 0 1 1 1 1 C5HC2 zinc finger GIY-YIG PF01541.24 KOS17224.1 - 2e-11 44.0 0.0 3.5e-11 43.2 0.0 1.4 1 0 0 1 1 1 1 GIY-YIG catalytic domain Ribosomal_60s PF00428.19 KOS17224.1 - 0.0093 16.5 3.1 0.017 15.7 3.1 1.4 1 0 0 1 1 1 1 60s Acidic ribosomal protein bZIP_1 PF00170.21 KOS17225.1 - 0.043 13.9 4.2 0.071 13.2 4.2 1.5 1 0 0 1 1 1 0 bZIP transcription factor tRNA-synt_1c PF00749.21 KOS17226.1 - 2e-105 352.1 0.1 2.6e-105 351.8 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOS17226.1 - 4.6e-37 127.6 0.0 6.9e-37 127.0 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_1e PF01406.19 KOS17226.1 - 0.033 13.5 0.2 0.086 12.2 0.2 1.5 1 1 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain SurE PF01975.17 KOS17227.1 - 4.1e-27 95.2 0.0 5.8e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE PE_PPE_C PF12484.8 KOS17227.1 - 0.028 15.3 1.4 0.057 14.3 1.4 1.5 1 0 0 1 1 1 0 Polymorphic PE/PPE proteins C terminal Alb1 PF09135.11 KOS17228.1 - 7.7e-25 87.8 10.5 1e-24 87.4 10.5 1.2 1 0 0 1 1 1 1 Alb1 DUF4650 PF15509.6 KOS17228.1 - 0.023 14.0 0.2 0.027 13.8 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) RXT2_N PF08595.11 KOS17228.1 - 0.04 13.9 2.7 0.055 13.5 2.7 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 KOS17228.1 - 0.048 13.0 3.0 0.063 12.6 3.0 1.2 1 0 0 1 1 1 0 NOA36 protein DivIVA PF05103.13 KOS17228.1 - 0.064 13.3 0.5 0.098 12.7 0.5 1.3 1 0 0 1 1 1 0 DivIVA protein RNA_pol_3_Rpc31 PF11705.8 KOS17228.1 - 0.067 13.4 7.6 0.086 13.1 7.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CENP-B_dimeris PF09026.10 KOS17228.1 - 0.67 10.4 8.5 1.2 9.5 8.5 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 KOS17228.1 - 2.2 8.0 12.9 1.8 8.3 11.7 1.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein MPP6 PF10175.9 KOS17228.1 - 3.9 8.0 8.7 11 6.5 8.7 1.8 1 1 0 1 1 1 0 M-phase phosphoprotein 6 E1-E2_ATPase PF00122.20 KOS17229.1 - 5.3e-49 166.2 1.8 5.3e-49 166.2 1.8 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOS17229.1 - 1e-34 120.7 4.1 1.1e-29 104.2 1.1 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOS17229.1 - 1.2e-07 31.7 0.2 9.3e-06 25.6 0.1 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS17229.1 - 0.0078 16.6 2.0 0.017 15.5 0.2 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase FAD_binding_1 PF00667.20 KOS17230.1 - 1.6e-60 204.4 0.0 2.7e-60 203.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOS17230.1 - 2.4e-10 41.0 0.0 5.3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain PFOR_II PF17147.4 KOS17230.1 - 4.2e-06 27.0 0.1 9.4e-06 25.9 0.1 1.6 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II POR PF01558.18 KOS17230.1 - 0.00035 20.7 0.0 0.00083 19.5 0.0 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Transketolase_C PF02780.20 KOS17230.1 - 0.0008 19.3 0.1 0.0028 17.5 0.1 1.9 2 0 0 2 2 2 1 Transketolase, C-terminal domain zf-Nse PF11789.8 KOS17231.1 - 6.4e-23 80.3 0.7 1.1e-22 79.6 0.7 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 KOS17231.1 - 0.00097 18.8 0.5 0.0017 18.0 0.5 1.4 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.6 KOS17231.1 - 0.0066 16.5 0.6 0.013 15.6 0.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger DUF3245 PF11595.8 KOS17231.1 - 0.037 14.5 1.9 0.037 14.5 1.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3245) zf-C3HC4_2 PF13923.6 KOS17231.1 - 0.047 13.5 0.2 0.082 12.8 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS17231.1 - 0.12 12.7 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain Vir_act_alpha_C PF10400.9 KOS17231.1 - 0.14 12.8 4.0 5 7.9 0.1 3.3 3 0 0 3 3 3 0 Virulence activator alpha C-term RXT2_N PF08595.11 KOS17231.1 - 3.2 7.7 10.8 1.9 8.5 2.2 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal PAS_9 PF13426.7 KOS17232.1 - 3.4e-12 46.5 0.0 4.3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 PAS domain PAS_3 PF08447.12 KOS17232.1 - 0.0013 19.0 0.0 0.69 10.2 0.0 2.1 1 1 1 2 2 2 2 PAS fold PAS PF00989.25 KOS17232.1 - 0.0018 18.3 0.0 0.0032 17.5 0.0 1.6 1 1 0 1 1 1 1 PAS fold PAS_8 PF13188.7 KOS17232.1 - 0.017 15.2 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 PAS domain Pkinase PF00069.25 KOS17233.1 - 1.6e-70 237.5 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17233.1 - 5.6e-32 111.0 0.0 6.9e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS17233.1 - 0.00064 18.8 0.0 0.0079 15.2 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KOS17233.1 - 0.00095 18.6 0.0 0.002 17.5 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KOS17233.1 - 0.0041 17.1 0.0 0.0079 16.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KOS17233.1 - 0.005 15.9 0.0 0.0076 15.3 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Kdo PF06293.14 KOS17233.1 - 0.022 14.1 0.1 0.07 12.5 0.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DSBA PF01323.20 KOS17234.1 - 5e-15 55.8 0.0 1.7e-14 54.1 0.0 1.7 2 0 0 2 2 2 1 DSBA-like thioredoxin domain CENP-B_dimeris PF09026.10 KOS17234.1 - 0.00063 20.1 8.7 0.0012 19.2 8.7 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Ribosomal_60s PF00428.19 KOS17234.1 - 0.0081 16.7 1.8 0.015 15.9 1.8 1.5 1 0 0 1 1 1 1 60s Acidic ribosomal protein RNA_pol_3_Rpc31 PF11705.8 KOS17234.1 - 0.046 14.0 8.2 0.067 13.4 8.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 KOS17234.1 - 0.082 12.9 1.6 0.12 12.4 1.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal CobT PF06213.12 KOS17234.1 - 0.12 11.8 4.6 0.18 11.1 4.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 KOS17234.1 - 0.13 11.9 2.4 0.22 11.2 2.4 1.3 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 KOS17234.1 - 0.2 9.7 7.4 0.26 9.4 7.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi WRNPLPNID PF15017.6 KOS17234.1 - 2 9.4 9.9 4.4 8.3 9.9 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box DUF4637 PF15470.6 KOS17234.1 - 2.5 7.8 5.9 4.3 7.0 5.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pox_Ag35 PF03286.14 KOS17234.1 - 5.1 6.8 8.8 7.7 6.2 8.8 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 KOS17234.1 - 6.9 5.9 12.4 9.9 5.4 12.4 1.1 1 0 0 1 1 1 0 NOA36 protein Cyclin_N PF00134.23 KOS17235.1 - 1.1e-14 54.3 0.2 2.2e-14 53.3 0.0 1.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin PF08613.11 KOS17235.1 - 8.5e-07 29.5 0.1 2.6e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 Cyclin DHBP_synthase PF00926.19 KOS17236.1 - 1.7e-80 269.1 0.0 1.9e-80 268.9 0.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase DUF5539 PF17693.1 KOS17236.1 - 0.064 12.9 1.5 0.091 12.4 1.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5539) Methyltransf_23 PF13489.6 KOS17237.1 - 2.2e-19 69.9 0.0 3e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17237.1 - 1.2e-17 64.5 0.0 1.8e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17237.1 - 3.2e-17 63.0 0.0 5.2e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS17237.1 - 1.2e-14 54.4 0.0 1.7e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS17237.1 - 1.4e-14 54.5 0.0 2.8e-14 53.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOS17237.1 - 0.00015 21.3 0.0 0.00025 20.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_9 PF08003.11 KOS17237.1 - 0.003 16.5 0.0 0.0046 15.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Ubie_methyltran PF01209.18 KOS17237.1 - 0.0054 16.1 0.0 0.0073 15.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KOS17237.1 - 0.0076 15.6 0.0 0.011 15.1 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 KOS17237.1 - 0.015 14.8 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain NodS PF05401.11 KOS17237.1 - 0.027 14.1 0.0 0.038 13.6 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein S (NodS) DREV PF05219.12 KOS17237.1 - 0.25 10.4 0.0 0.33 10.0 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase UPF0029 PF01205.19 KOS17238.1 - 6.3e-24 84.3 0.0 1.4e-23 83.2 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 DUF5329 PF17263.2 KOS17238.1 - 0.074 13.2 0.3 0.15 12.2 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5329) Stm1_N PF09598.10 KOS17238.1 - 8.4 7.3 6.7 6.7 7.6 0.6 2.5 2 0 0 2 2 2 0 Stm1 MBOAT PF03062.19 KOS17239.1 - 6.2e-36 124.5 17.9 2.4e-34 119.2 11.6 2.5 2 1 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Popeye PF04831.13 KOS17239.1 - 4.5 7.4 8.1 2.9 8.1 3.0 2.5 2 0 0 2 2 2 0 Popeye protein conserved region NCBP3 PF10309.9 KOS17240.1 - 4.1e-21 74.6 0.1 8.1e-21 73.6 0.1 1.5 1 0 0 1 1 1 1 Nuclear cap-binding protein subunit 3 RNA_bind PF08675.11 KOS17240.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 RNA binding domain DNA_pol_B_thumb PF14791.6 KOS17241.1 - 4.5e-20 71.6 0.3 2.2e-19 69.4 0.1 2.2 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 KOS17241.1 - 3.3e-17 62.1 0.3 7.2e-17 61.0 0.3 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda DNA_pol_B_palm PF14792.6 KOS17241.1 - 6.6e-16 58.5 0.1 1.4e-15 57.5 0.1 1.6 1 1 0 1 1 1 1 DNA polymerase beta palm HHH_8 PF14716.6 KOS17241.1 - 1.1e-11 44.9 0.1 5.3e-11 42.7 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.6 KOS17241.1 - 0.0011 19.5 0.0 0.051 14.2 0.0 2.6 2 0 0 2 2 2 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 KOS17241.1 - 0.068 13.5 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Nucleotidyltransferase domain BRCT_2 PF16589.5 KOS17241.1 - 0.14 12.5 0.0 0.33 11.4 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain TFIIE_alpha PF02002.17 KOS17242.1 - 5e-09 36.0 0.1 1.3e-08 34.6 0.1 1.6 1 0 0 1 1 1 1 TFIIE alpha subunit Drc1-Sld2 PF11719.8 KOS17242.1 - 0.042 13.4 3.4 0.058 12.9 3.4 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein zf-Dof PF02701.15 KOS17242.1 - 0.15 12.3 0.3 0.46 10.7 0.3 1.8 1 1 0 1 1 1 0 Dof domain, zinc finger HEAT_EZ PF13513.6 KOS17243.1 - 7.8e-23 80.6 23.6 4.8e-15 55.7 0.1 10.9 11 2 3 14 14 13 4 HEAT-like repeat HEAT PF02985.22 KOS17243.1 - 2e-22 77.3 11.0 0.00023 21.1 0.0 9.6 9 0 0 9 9 9 4 HEAT repeat HEAT_2 PF13646.6 KOS17243.1 - 8.6e-15 54.9 2.4 0.004 17.5 0.0 6.6 7 1 1 8 8 8 3 HEAT repeats Cnd1 PF12717.7 KOS17243.1 - 1.5e-08 34.9 0.1 0.024 14.7 0.0 4.5 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 IBN_N PF03810.19 KOS17243.1 - 5.9e-08 32.5 0.9 6.7e-06 25.9 0.1 4.4 4 1 0 4 4 4 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 KOS17243.1 - 7.9e-08 32.8 0.0 0.029 15.0 0.0 5.1 4 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 KOS17243.1 - 4.5e-05 22.7 2.6 0.55 9.3 0.0 4.4 5 1 0 5 5 5 2 RNAPII transcription regulator C-terminal Arm PF00514.23 KOS17243.1 - 0.00097 19.1 3.1 0.34 11.0 0.0 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 KOS17243.1 - 0.0019 17.8 0.0 15 5.1 0.0 5.1 4 1 1 5 5 5 0 CLASP N terminal HEAT_PBS PF03130.16 KOS17243.1 - 0.067 13.9 2.5 1.3 9.9 0.0 4.3 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF3437 PF11919.8 KOS17243.1 - 0.072 13.0 0.0 2.4 8.1 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) RIX1 PF08167.12 KOS17243.1 - 0.12 12.1 0.0 13 5.4 0.0 3.2 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis NOA36 PF06524.12 KOS17243.1 - 6.3 6.0 16.7 12 5.1 16.7 1.4 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 KOS17243.1 - 7.1 7.1 18.4 2 8.8 13.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Fungal_trans_2 PF11951.8 KOS17244.1 - 3e-07 29.6 3.3 3.8e-07 29.3 2.4 1.4 1 1 0 1 1 1 1 Fungal specific transcription factor domain SNARE PF05739.19 KOS17245.1 - 2.9e-13 49.6 1.4 7.2e-13 48.3 1.4 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 KOS17245.1 - 0.00048 19.8 9.9 0.044 13.4 0.9 2.2 2 0 0 2 2 2 2 Syntaxin DASH_Dad4 PF08650.10 KOS17245.1 - 0.0086 16.0 2.9 0.16 12.0 0.1 2.4 2 0 0 2 2 2 1 DASH complex subunit Dad4 DNA_repr_REX1B PF14966.6 KOS17245.1 - 0.15 12.7 0.4 0.15 12.7 0.4 2.5 3 1 0 3 3 3 0 DNA repair REX1-B MCPsignal PF00015.21 KOS17245.1 - 0.2 11.4 9.7 0.3 10.9 0.8 2.2 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SlyX PF04102.12 KOS17245.1 - 2.8 8.6 10.7 4.3 8.0 0.2 3.5 2 1 1 3 3 3 0 SlyX EF-hand_1 PF00036.32 KOS17246.1 - 6.7e-40 131.7 12.1 7.8e-10 37.6 0.9 4.1 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOS17246.1 - 2.8e-35 120.6 5.1 3.9e-18 65.7 2.1 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOS17246.1 - 1.1e-32 111.6 11.0 9.4e-15 54.2 0.6 4.0 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_6 PF13405.6 KOS17246.1 - 6.5e-29 97.4 8.4 1.9e-09 36.7 0.2 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOS17246.1 - 4.4e-25 86.0 10.3 2.6e-06 26.7 0.3 4.3 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 KOS17246.1 - 2.7e-15 56.4 0.3 1.9e-08 34.5 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 KOS17246.1 - 9.5e-09 35.2 1.8 0.0012 18.8 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 KOS17246.1 - 3.1e-08 33.9 0.2 0.0033 17.7 0.2 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 KOS17246.1 - 1.9e-06 27.8 0.0 0.0051 16.8 0.0 3.0 2 1 1 3 3 3 2 Uncharacterised protein family (UPF0154) EFhand_Ca_insen PF08726.10 KOS17246.1 - 1.2e-05 25.3 1.5 4.5e-05 23.5 0.2 2.3 2 1 0 2 2 2 1 Ca2+ insensitive EF hand EF-hand_11 PF08976.11 KOS17246.1 - 0.00023 22.0 0.1 0.0067 17.3 0.1 2.1 1 1 1 2 2 2 1 EF-hand domain TerB PF05099.13 KOS17246.1 - 0.0004 20.4 0.2 0.26 11.2 0.1 2.3 1 1 1 2 2 2 2 Tellurite resistance protein TerB Caleosin PF05042.13 KOS17246.1 - 0.00079 19.4 1.3 0.67 9.9 0.0 3.5 1 1 3 4 4 4 1 Caleosin related protein DUF3349 PF11829.8 KOS17246.1 - 0.0021 18.8 0.3 3.5 8.5 0.0 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) RNA_pol_Rpb4 PF03874.16 KOS17246.1 - 0.004 17.5 0.8 2 8.8 0.1 2.7 2 1 1 3 3 3 1 RNA polymerase Rpb4 DUF5580 PF17743.1 KOS17246.1 - 0.0082 14.7 0.0 0.0084 14.7 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Dockerin_1 PF00404.18 KOS17246.1 - 0.0091 16.2 5.3 0.73 10.1 0.7 3.1 1 1 2 3 3 3 1 Dockerin type I domain SurA_N_2 PF13623.6 KOS17246.1 - 0.012 15.5 0.5 1.1 9.2 0.1 2.3 1 1 1 2 2 2 0 SurA N-terminal domain EF-hand_14 PF17959.1 KOS17246.1 - 0.018 15.4 0.3 5.7 7.3 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain MotA_activ PF09114.10 KOS17246.1 - 0.063 13.4 0.0 0.93 9.7 0.0 2.2 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Poly_export PF02563.16 KOS17246.1 - 0.064 13.5 0.0 0.6 10.4 0.0 2.5 2 1 0 2 2 2 0 Polysaccharide biosynthesis/export protein RloB PF13707.6 KOS17246.1 - 0.2 11.8 0.9 1 9.5 0.2 2.0 1 1 1 2 2 2 0 RloB-like protein DUF5427 PF10310.9 KOS17247.1 - 1.4 7.8 7.3 2.3 7.1 7.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Exo_endo_phos PF03372.23 KOS17248.1 - 4.1e-10 39.6 0.3 7.1e-10 38.8 0.3 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KOS17248.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase F-box PF00646.33 KOS17250.1 - 0.014 15.3 1.3 0.026 14.4 0.1 2.1 2 0 0 2 2 2 0 F-box domain DUF3455 PF11937.8 KOS17251.1 - 2.3e-40 138.6 0.1 2.8e-40 138.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) Reovirus_M2 PF05993.12 KOS17251.1 - 0.21 9.7 2.0 0.8 7.7 0.1 1.9 2 0 0 2 2 2 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) PE_PPE_C PF12484.8 KOS17251.1 - 8.6 7.4 10.9 12 6.9 2.3 2.6 2 1 1 3 3 3 0 Polymorphic PE/PPE proteins C terminal CASP_C PF08172.12 KOS17252.1 - 5.2e-93 311.0 0.0 5.2e-93 311.0 0.0 3.4 4 0 0 4 4 4 1 CASP C terminal Fib_alpha PF08702.10 KOS17252.1 - 0.015 15.5 8.5 0.015 15.5 8.5 5.1 5 1 0 5 5 5 0 Fibrinogen alpha/beta chain family DUF4164 PF13747.6 KOS17252.1 - 0.016 15.4 1.0 0.016 15.4 1.0 5.9 5 1 0 5 5 5 0 Domain of unknown function (DUF4164) HSR PF03172.13 KOS17252.1 - 0.085 13.0 1.1 0.29 11.3 0.0 2.3 2 0 0 2 2 2 0 HSR domain NAD_binding_1 PF00175.21 KOS17252.1 - 0.17 12.5 2.5 3.6 8.3 0.0 3.3 3 0 0 3 3 3 0 Oxidoreductase NAD-binding domain Rad9 PF04139.13 KOS17252.1 - 0.18 11.2 4.6 0.34 10.3 4.0 1.5 1 1 0 1 1 1 0 Rad9 TolA_bind_tri PF16331.5 KOS17252.1 - 1 9.5 38.0 3 8.0 4.1 6.3 6 0 0 6 6 6 0 TolA binding protein trimerisation APG6_N PF17675.1 KOS17252.1 - 1.7 9.2 70.1 1.1 9.8 0.4 5.9 2 1 3 5 5 5 0 Apg6 coiled-coil region Shugoshin_N PF07558.11 KOS17252.1 - 7.1 6.6 9.9 4.3 7.3 0.2 4.5 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region Jnk-SapK_ap_N PF09744.9 KOS17252.1 - 7.9 6.7 58.5 3.4 7.9 15.3 5.1 5 0 0 5 5 5 0 JNK_SAPK-associated protein-1 Myosin_tail_1 PF01576.19 KOS17252.1 - 8.4 4.0 60.4 0.18 9.6 3.7 3.3 3 1 0 3 3 3 0 Myosin tail Vps39_1 PF10366.9 KOS17254.1 - 0.00019 21.7 0.2 0.0081 16.4 0.0 2.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 KOS17254.1 - 0.0024 18.3 0.0 0.0067 16.9 0.0 1.7 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 KOS17254.1 - 0.0086 15.9 0.0 0.025 14.4 0.0 1.7 1 0 0 1 1 1 1 Region in Clathrin and VPS TPR_7 PF13176.6 KOS17254.1 - 0.17 12.0 0.5 2.7 8.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_16 PF10294.9 KOS17255.1 - 5.3e-05 23.0 0.0 0.012 15.3 0.0 2.2 2 0 0 2 2 2 2 Lysine methyltransferase zf-C2H2 PF00096.26 KOS17256.1 - 1.1e-05 25.6 16.7 0.64 10.6 0.4 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type FOXP-CC PF16159.5 KOS17256.1 - 0.0095 16.6 4.1 0.73 10.5 0.6 3.5 3 0 0 3 3 3 1 FOXP coiled-coil domain zf-C2H2_2 PF12756.7 KOS17256.1 - 0.035 14.4 0.1 0.035 14.4 0.1 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 KOS17256.1 - 0.035 14.5 0.8 3.2 8.3 0.0 2.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_4 PF13894.6 KOS17256.1 - 0.054 14.4 18.4 1.8 9.6 0.2 4.9 4 1 0 4 4 4 0 C2H2-type zinc finger Pox_G9-A16 PF03003.16 KOS17256.1 - 0.081 12.6 0.1 0.19 11.5 0.1 1.6 1 0 0 1 1 1 0 Pox virus entry-fusion-complex G9/A16 TOC159_MAD PF11886.8 KOS17256.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Translocase of chloroplast 159/132, membrane anchor domain zf-TAZ PF02135.16 KOS17256.1 - 0.3 11.6 6.1 0.26 11.8 1.9 2.3 2 0 0 2 2 2 0 TAZ zinc finger Fibrillarin PF01269.17 KOS17258.1 - 1.2e-99 332.0 0.0 1.5e-99 331.7 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 KOS17258.1 - 1.2e-05 25.2 0.0 1.9e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Ribosomal_L22 PF00237.19 KOS17259.1 - 4.4e-40 136.1 0.1 6e-40 135.6 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e LTD PF00932.19 KOS17259.1 - 0.13 12.7 0.0 0.14 12.5 0.0 1.4 1 1 0 1 1 1 0 Lamin Tail Domain Elf1 PF05129.13 KOS17260.1 - 2.2e-29 101.3 0.2 2.6e-29 101.1 0.2 1.1 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like PHD_4 PF16866.5 KOS17260.1 - 0.049 13.7 0.2 0.073 13.2 0.2 1.3 1 0 0 1 1 1 0 PHD-finger Cys_rich_CPXG PF14255.6 KOS17260.1 - 0.085 12.8 0.8 0.14 12.1 0.8 1.4 1 0 0 1 1 1 0 Cysteine-rich CPXCG PEMT PF04191.13 KOS17261.1 - 1.2e-28 99.6 0.7 1.9e-28 98.9 0.7 1.3 1 0 0 1 1 1 1 Phospholipid methyltransferase DNA_primase_lrg PF04104.14 KOS17262.1 - 3.7e-80 269.2 0.0 5e-80 268.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Pkinase PF00069.25 KOS17263.1 - 3.3e-44 151.2 0.0 6.7e-43 147.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17263.1 - 4.5e-28 98.2 0.0 6.5e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS17263.1 - 0.039 12.7 0.0 0.055 12.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 KOS17263.1 - 0.042 13.2 0.1 0.17 11.1 0.1 1.9 1 1 0 1 1 1 0 Kinase-like GCD14 PF08704.10 KOS17264.1 - 0.053 13.2 0.0 8.3 6.0 0.0 2.2 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Sugar_tr PF00083.24 KOS17267.1 - 1.9e-93 313.8 20.3 2.4e-93 313.5 20.3 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17267.1 - 8.5e-11 41.4 42.8 9e-08 31.4 16.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4293 PF14126.6 KOS17267.1 - 1.3 9.2 5.9 21 5.3 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) SpoIIP PF07454.11 KOS17268.1 - 0.012 15.1 12.8 0.012 15.1 12.8 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CobT PF06213.12 KOS17268.1 - 0.021 14.2 26.5 0.02 14.3 26.5 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 KOS17268.1 - 0.031 13.0 11.5 0.033 13.0 11.5 1.0 1 0 0 1 1 1 0 Presenilin FYDLN_acid PF09538.10 KOS17268.1 - 0.033 14.9 15.1 0.038 14.7 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 KOS17268.1 - 0.036 14.5 9.3 0.033 14.6 9.3 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 KOS17268.1 - 0.057 12.8 21.9 0.057 12.8 21.9 1.0 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 KOS17268.1 - 0.057 12.8 18.6 0.059 12.7 18.6 1.0 1 0 0 1 1 1 0 BUD22 Dynamin_N PF00350.23 KOS17268.1 - 0.067 13.3 4.8 0.084 12.9 4.8 1.1 1 0 0 1 1 1 0 Dynamin family Eapp_C PF10238.9 KOS17268.1 - 0.071 13.2 10.4 0.077 13.1 10.4 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DUF2722 PF10846.8 KOS17268.1 - 0.089 11.7 13.1 0.096 11.6 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2956 PF11169.8 KOS17268.1 - 0.11 12.7 9.8 0.14 12.4 9.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DDHD PF02862.17 KOS17268.1 - 0.13 12.4 7.0 0.13 12.4 7.0 1.1 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 KOS17268.1 - 0.23 9.7 19.3 0.21 9.8 19.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5523 PF17661.1 KOS17268.1 - 0.27 10.9 25.0 0.3 10.8 25.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF4628 PF15429.6 KOS17268.1 - 0.27 10.9 13.1 0.28 10.8 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) Plasmodium_Vir PF05795.11 KOS17268.1 - 0.32 10.4 9.1 0.31 10.4 9.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Zip PF02535.22 KOS17268.1 - 0.32 10.2 8.2 0.33 10.1 8.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 KOS17268.1 - 0.34 9.7 11.9 0.36 9.6 11.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CTU2 PF10288.9 KOS17268.1 - 0.43 10.8 9.1 0.55 10.5 9.1 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 PPL5 PF18168.1 KOS17268.1 - 0.65 9.2 11.1 0.76 9.0 11.1 1.0 1 0 0 1 1 1 0 Prim-pol family 5 DNA_pol_phi PF04931.13 KOS17268.1 - 0.7 7.9 27.2 0.72 7.9 27.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi Slu7 PF11708.8 KOS17268.1 - 0.72 9.6 18.0 0.83 9.4 18.0 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor DUF4175 PF13779.6 KOS17268.1 - 0.79 7.5 16.5 0.83 7.5 16.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PIP5K PF01504.18 KOS17268.1 - 0.96 8.6 8.7 1.1 8.5 8.7 1.0 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase RP-C_C PF11800.8 KOS17268.1 - 1.1 9.4 10.0 1.2 9.2 10.0 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region CCDC53 PF10152.9 KOS17268.1 - 1.1 9.6 13.1 1.3 9.4 13.1 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Connexin PF00029.19 KOS17268.1 - 1.1 8.9 14.1 1.3 8.7 14.1 1.0 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 KOS17268.1 - 1.3 8.5 10.2 1.5 8.3 10.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 EIIBC-GUT_N PF03612.14 KOS17268.1 - 1.4 8.7 11.2 1.8 8.3 11.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF5308 PF17233.2 KOS17268.1 - 1.6 8.9 7.7 1.8 8.8 7.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) FAM60A PF15396.6 KOS17268.1 - 1.8 8.5 8.1 2.1 8.3 8.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Membralin PF09746.9 KOS17268.1 - 1.9 7.5 4.6 1.9 7.4 4.6 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF4337 PF14235.6 KOS17268.1 - 1.9 8.6 11.1 2.1 8.4 11.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF4471 PF14740.6 KOS17268.1 - 1.9 7.6 10.9 2 7.5 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) CDC27 PF09507.10 KOS17268.1 - 2.2 7.5 19.2 2.4 7.4 19.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 OATP PF03137.20 KOS17268.1 - 2.3 6.4 6.6 2.4 6.3 6.6 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family BORG_CEP PF14957.6 KOS17268.1 - 2.5 9.3 8.4 2.8 9.1 8.4 1.1 1 0 0 1 1 1 0 Cdc42 effector MDM10 PF12519.8 KOS17268.1 - 2.5 6.8 9.1 2.8 6.7 9.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CLN3 PF02487.17 KOS17268.1 - 2.6 7.0 9.5 2.9 6.9 9.5 1.0 1 0 0 1 1 1 0 CLN3 protein DUF4407 PF14362.6 KOS17268.1 - 2.7 7.3 7.4 3 7.1 7.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kei1 PF08552.11 KOS17268.1 - 2.8 7.8 4.0 2.9 7.7 4.0 1.0 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 NARP1 PF12569.8 KOS17268.1 - 2.8 6.7 17.3 3 6.6 17.3 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SLC12 PF03522.15 KOS17268.1 - 2.8 6.8 10.6 3.2 6.7 10.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Spore_coat_CotO PF14153.6 KOS17268.1 - 3 7.8 25.3 3.5 7.5 25.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO ALMT PF11744.8 KOS17268.1 - 3 6.6 8.2 3.3 6.5 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM91_C PF14648.6 KOS17268.1 - 3.1 6.5 7.6 3.4 6.4 7.6 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Endostatin PF06482.11 KOS17268.1 - 3.4 7.1 8.2 3.7 6.9 8.2 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Pannexin_like PF12534.8 KOS17268.1 - 4.5 6.3 7.5 4.9 6.1 7.5 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 XRN_M PF17846.1 KOS17268.1 - 4.6 6.1 9.6 4.8 6.0 9.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Nop14 PF04147.12 KOS17268.1 - 4.7 5.3 27.7 5.4 5.1 27.7 1.0 1 0 0 1 1 1 0 Nop14-like family Neur_chan_memb PF02932.16 KOS17268.1 - 4.8 7.2 7.5 4.7 7.2 7.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ATP-synt_E PF05680.12 KOS17268.1 - 4.9 7.6 19.0 6.7 7.1 19.0 1.2 1 0 0 1 1 1 0 ATP synthase E chain Gti1_Pac2 PF09729.9 KOS17268.1 - 5 7.2 10.1 5.9 6.9 10.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Tim54 PF11711.8 KOS17268.1 - 6.1 5.5 22.1 6.7 5.4 22.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 KOS17268.1 - 6.3 6.5 24.6 7.3 6.3 24.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 KOS17268.1 - 6.4 5.7 33.4 7.1 5.5 33.4 1.0 1 0 0 1 1 1 0 Paf1 DUF2151 PF10221.9 KOS17268.1 - 6.5 5.2 12.7 7.3 5.0 12.7 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator XAP5 PF04921.14 KOS17268.1 - 6.8 6.4 16.2 7.8 6.2 16.2 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator FHIPEP PF00771.20 KOS17268.1 - 6.9 5.0 7.9 8.5 4.7 7.9 1.3 1 0 0 1 1 1 0 FHIPEP family COPI_C PF06957.11 KOS17268.1 - 7 5.3 17.0 7.3 5.2 17.0 1.0 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus CPSF100_C PF13299.6 KOS17268.1 - 7.2 6.8 17.0 8.8 6.5 17.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Mpp10 PF04006.12 KOS17268.1 - 7.7 4.8 30.1 8.7 4.7 30.1 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF4770 PF15994.5 KOS17268.1 - 7.9 6.7 11.1 10 6.3 11.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Peptidase_U57 PF05582.12 KOS17268.1 - 8 5.6 8.3 9.1 5.4 8.3 1.0 1 0 0 1 1 1 0 YabG peptidase U57 FancD2 PF14631.6 KOS17268.1 - 8.3 3.7 9.7 8.5 3.6 9.7 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF4045 PF13254.6 KOS17268.1 - 8.5 5.9 14.8 9.9 5.7 14.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Cellulose_synt PF03552.14 KOS17268.1 - 8.7 4.7 7.3 9.8 4.5 7.3 1.1 1 0 0 1 1 1 0 Cellulose synthase DDRGK PF09756.9 KOS17268.1 - 9.4 5.8 34.1 12 5.5 34.1 1.0 1 0 0 1 1 1 0 DDRGK domain Pox_Ag35 PF03286.14 KOS17268.1 - 9.5 6.0 22.2 12 5.6 22.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Coilin_N PF15862.5 KOS17268.1 - 9.6 6.0 20.2 12 5.7 20.2 1.1 1 0 0 1 1 1 0 Coilin N-terminus FA_desaturase PF00487.24 KOS17269.1 - 0.75 9.6 2.7 0.73 9.6 2.7 1.0 1 0 0 1 1 1 0 Fatty acid desaturase PAS PF00989.25 KOS17270.1 - 0.0035 17.3 0.0 0.0069 16.4 0.0 1.4 1 0 0 1 1 1 1 PAS fold MFS_1 PF07690.16 KOS17271.1 - 6.7e-35 120.6 42.1 6.7e-35 120.6 42.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS17271.1 - 5.9e-10 38.6 11.6 5.9e-10 38.6 11.6 2.1 2 1 0 2 2 2 1 Sugar (and other) transporter Peptidase_M35 PF02102.15 KOS17272.1 - 9.8e-58 195.7 10.5 4.5e-56 190.3 10.5 2.0 1 1 0 1 1 1 1 Deuterolysin metalloprotease (M35) family Aspzincin_M35 PF14521.6 KOS17272.1 - 8.9e-38 130.1 1.8 1.7e-37 129.2 1.8 1.5 1 0 0 1 1 1 1 Lysine-specific metallo-endopeptidase DUF3906 PF13046.6 KOS17272.1 - 0.069 13.2 0.2 0.13 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) LRR_8 PF13855.6 KOS17273.1 - 1.8e-31 107.7 38.8 3.6e-07 29.8 5.4 9.0 4 3 7 11 11 11 10 Leucine rich repeat LRR_4 PF12799.7 KOS17273.1 - 3e-29 100.6 34.0 8.5e-06 26.0 1.0 9.3 5 2 4 10 10 10 10 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 KOS17273.1 - 3.3e-10 39.2 32.0 0.22 11.7 0.7 12.7 14 0 0 14 14 14 4 Leucine Rich repeat LRR_9 PF14580.6 KOS17273.1 - 6.8e-08 32.2 18.9 0.007 15.9 0.3 5.4 3 2 3 6 6 6 5 Leucine-rich repeat LRR_1 PF00560.33 KOS17273.1 - 1.4e-05 24.9 28.3 51 5.0 0.2 11.4 11 3 1 12 12 12 0 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 KOS17273.1 - 0.058 13.4 0.1 0.67 10.0 0.0 2.8 3 1 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain KHA PF11834.8 KOS17273.1 - 0.13 12.4 0.0 0.73 10.0 0.0 2.2 2 0 0 2 2 2 0 KHA, dimerisation domain of potassium ion channel MRP-L27 PF09809.9 KOS17274.1 - 2.6e-17 62.7 0.3 3e-17 62.5 0.3 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 zf-RING_2 PF13639.6 KOS17275.1 - 2.2e-09 37.5 5.5 3.1e-09 37.0 5.5 1.2 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOS17275.1 - 1.3e-07 31.8 4.3 3.1e-07 30.6 4.3 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 KOS17275.1 - 3.5e-05 23.8 3.0 7.5e-05 22.7 3.0 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOS17275.1 - 0.0029 17.4 4.4 0.0054 16.6 4.4 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17275.1 - 0.0051 16.6 5.9 0.01 15.6 5.9 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS17275.1 - 0.019 14.7 1.8 0.019 14.7 1.8 2.2 2 0 0 2 2 2 0 RING-like zinc finger NMD3 PF04981.13 KOS17275.1 - 0.03 13.8 0.0 0.037 13.5 0.0 1.2 1 0 0 1 1 1 0 NMD3 family zf-C3HC4 PF00097.25 KOS17275.1 - 0.064 13.1 4.3 0.11 12.4 4.3 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 KOS17275.1 - 0.065 13.0 1.9 0.13 12.0 0.4 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Tmpp129 PF10272.9 KOS17275.1 - 0.21 10.8 0.3 0.33 10.2 0.3 1.2 1 0 0 1 1 1 0 Putative transmembrane protein precursor NAD_binding_10 PF13460.6 KOS17276.1 - 2.5e-11 43.8 2.5 3.6e-11 43.3 2.5 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOS17276.1 - 1.2e-09 38.0 0.1 2e-09 37.3 0.1 1.4 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KOS17276.1 - 5.1e-08 32.8 0.7 6.9e-08 32.3 0.7 1.1 1 0 0 1 1 1 1 NmrA-like family HIM1 PF08732.10 KOS17276.1 - 0.005 16.4 0.0 0.0071 15.9 0.0 1.2 1 0 0 1 1 1 1 HIM1 3Beta_HSD PF01073.19 KOS17276.1 - 0.011 14.8 0.0 0.027 13.5 0.0 1.7 1 1 1 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOS17276.1 - 0.059 12.5 0.0 0.58 9.3 0.0 2.2 2 1 1 3 3 3 0 Male sterility protein Flavokinase PF01687.17 KOS17277.1 - 5.6e-36 123.2 0.0 7e-36 122.9 0.0 1.0 1 0 0 1 1 1 1 Riboflavin kinase Spt20 PF12090.8 KOS17278.1 - 0.0046 16.6 22.0 0.011 15.3 22.0 1.6 1 0 0 1 1 1 1 Spt20 family Tim54 PF11711.8 KOS17278.1 - 5.4 5.7 17.5 15 4.2 17.5 1.7 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Spt20 PF12090.8 KOS17279.1 - 0.36 10.4 5.1 0.33 10.5 5.1 1.1 1 0 0 1 1 1 0 Spt20 family FBPase PF00316.20 KOS17280.1 - 9e-21 74.2 0.5 1.4e-12 47.5 0.1 2.2 2 0 0 2 2 2 2 Fructose-1-6-bisphosphatase, N-terminal domain Amidohydro_1 PF01979.20 KOS17281.1 - 3.5e-10 39.7 0.0 1.3e-09 37.9 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOS17281.1 - 9.8e-09 35.2 0.0 1.3e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family NDT80_PhoG PF05224.12 KOS17282.1 - 1.9e-35 122.8 0.0 3e-35 122.1 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family PT PF04886.12 KOS17282.1 - 0.016 14.8 5.2 0.042 13.4 5.2 1.7 1 0 0 1 1 1 0 PT repeat Glyco_hydro_3 PF00933.21 KOS17283.1 - 3.8e-66 223.6 0.0 5.1e-66 223.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Acetyltransf_1 PF00583.25 KOS17283.1 - 0.0046 17.2 0.0 0.034 14.4 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Fe_hyd_SSU PF02256.17 KOS17283.1 - 0.005 16.9 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 2 Iron hydrogenase small subunit Glyco_hydro_3_C PF01915.22 KOS17283.1 - 0.026 14.5 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 C-terminal domain CorA PF01544.18 KOS17284.1 - 3.4e-07 29.9 0.3 4.3e-07 29.5 0.3 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF2738 PF10927.8 KOS17284.1 - 0.11 11.6 0.1 0.15 11.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2738) V-SNARE_C PF12352.8 KOS17284.1 - 0.32 11.3 5.1 0.49 10.7 0.2 2.7 2 1 1 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus HET PF06985.11 KOS17285.1 - 6.4e-27 94.7 0.0 1.1e-26 93.9 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Formyl_trans_N PF00551.19 KOS17286.1 - 8e-31 107.2 0.0 9.6e-31 106.9 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase WGG PF10273.9 KOS17287.1 - 1.7e-35 121.5 1.1 2.1e-35 121.2 0.3 1.5 2 0 0 2 2 2 1 Pre-rRNA-processing protein TSR2 Spc42p PF11544.8 KOS17287.1 - 0.17 11.9 1.0 0.23 11.5 0.0 1.6 2 0 0 2 2 2 0 Spindle pole body component Spc42p RRP7 PF12923.7 KOS17287.1 - 0.23 11.6 0.0 0.23 11.6 0.0 2.6 3 1 1 4 4 4 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Abhydrolase_3 PF07859.13 KOS17288.1 - 6.9e-38 130.6 0.0 1.8e-29 103.1 0.1 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOS17288.1 - 9.1e-13 47.8 0.0 1.3e-11 44.0 0.0 2.2 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 KOS17288.1 - 0.0023 16.9 0.5 0.028 13.3 0.5 2.1 1 1 0 1 1 1 1 Carboxylesterase family PAP1 PF08601.10 KOS17289.1 - 6.8e-61 207.0 16.6 6.5e-51 174.2 0.6 2.0 1 1 1 2 2 2 2 Transcription factor PAP1 BSD PF03909.17 KOS17290.1 - 2.8e-17 62.5 1.6 6.6e-17 61.3 0.1 2.1 2 0 0 2 2 2 1 BSD domain Suf PF05843.14 KOS17290.1 - 0.0071 16.4 5.4 0.066 13.2 0.6 2.2 2 0 0 2 2 2 2 Suppressor of forked protein (Suf) Sigma70_r2 PF04542.14 KOS17290.1 - 0.086 12.6 0.2 0.19 11.6 0.2 1.5 1 0 0 1 1 1 0 Sigma-70 region 2 Tcf25 PF04910.14 KOS17290.1 - 0.095 11.8 0.0 4.1 6.4 0.1 2.1 2 0 0 2 2 2 0 Transcriptional repressor TCF25 EzrA PF06160.12 KOS17290.1 - 0.16 10.1 2.0 0.62 8.2 0.0 2.1 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 KOS17290.1 - 0.46 9.8 2.7 0.86 8.9 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPRTase PF14681.6 KOS17291.1 - 7.7e-76 254.1 0.0 9.3e-76 253.9 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KOS17291.1 - 0.00034 20.1 0.0 0.00043 19.8 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain WAPL PF07814.13 KOS17292.1 - 1.8e-32 112.6 1.4 2.3e-32 112.2 1.4 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin Glyco_hydro_114 PF03537.13 KOS17293.1 - 0.056 12.7 0.0 0.056 12.7 0.0 1.0 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 GTP_CH_N PF12471.8 KOS17294.1 - 1.1e-28 100.3 0.3 4e-18 65.9 0.0 2.2 1 1 1 2 2 2 2 GTP cyclohydrolase N terminal F-actin_cap_A PF01267.17 KOS17295.1 - 7.3e-70 235.4 0.0 3e-62 210.5 0.0 2.0 1 1 1 2 2 2 2 F-actin capping protein alpha subunit ACAS_N PF16177.5 KOS17295.1 - 0.0099 15.8 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Transket_pyr PF02779.24 KOS17296.1 - 1.7e-46 158.1 0.1 2.8e-46 157.4 0.1 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOS17296.1 - 4.9e-31 107.2 0.3 1e-30 106.1 0.1 1.6 2 0 0 2 2 2 1 Transketolase, C-terminal domain PFOR_II PF17147.4 KOS17296.1 - 0.00062 20.0 0.1 0.0044 17.3 0.1 2.3 2 0 0 2 2 2 1 Pyruvate:ferredoxin oxidoreductase core domain II TyeA PF09059.10 KOS17296.1 - 0.013 15.6 0.1 0.037 14.1 0.1 1.8 2 0 0 2 2 2 0 TyeA Ribosomal_L7Ae PF01248.26 KOS17298.1 - 9e-22 76.6 0.8 1.6e-21 75.9 0.8 1.4 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family CLPTM1 PF05602.12 KOS17298.1 - 0.045 12.8 0.2 0.056 12.4 0.2 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) ATP_bind_3 PF01171.20 KOS17299.1 - 1.3e-17 64.1 0.0 2e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 PP-loop family zn-ribbon_14 PF16503.5 KOS17299.1 - 8.7e-17 60.3 5.0 8.7e-17 60.3 5.0 3.9 5 0 0 5 5 5 1 Zinc-ribbon tRNA_Me_trans PF03054.16 KOS17299.1 - 0.019 13.8 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase RecR PF02132.15 KOS17299.1 - 0.14 11.7 0.3 0.14 11.7 0.3 3.4 4 0 0 4 4 4 0 RecR protein MWFE PF15879.5 KOS17300.1 - 4.2e-24 84.5 0.1 4.5e-24 84.4 0.1 1.0 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase MWFE subunit Ran-binding PF05508.11 KOS17301.1 - 7.9e-115 383.1 0.0 9.7e-115 382.8 0.0 1.1 1 0 0 1 1 1 1 RanGTP-binding protein GTP_EFTU PF00009.27 KOS17302.1 - 1.1e-42 145.8 0.0 1.7e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOS17302.1 - 3.7e-28 98.1 0.1 1.2e-27 96.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOS17302.1 - 1.8e-09 37.9 0.2 4.3e-09 36.6 0.2 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOS17302.1 - 0.0018 18.3 0.1 0.0086 16.2 0.1 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRP-alpha_N PF04086.13 KOS17302.1 - 5.9 6.7 8.2 12 5.7 8.2 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PEPCK_ATP PF01293.20 KOS17303.1 - 8.6e-192 637.9 0.0 1e-191 637.7 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 KOS17303.1 - 0.15 12.3 0.0 0.27 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain MFS_1 PF07690.16 KOS17304.1 - 5e-34 117.8 28.0 9.6e-34 116.8 27.6 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Wzz PF02706.15 KOS17304.1 - 0.046 14.0 0.3 0.046 14.0 0.3 2.3 3 0 0 3 3 3 0 Chain length determinant protein ESSS PF10183.9 KOS17304.1 - 0.12 12.6 0.1 0.47 10.7 0.1 2.1 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF1358 PF07096.11 KOS17304.1 - 0.28 11.2 1.7 13 5.8 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1358) SPRY PF00622.28 KOS17305.1 - 7.3e-19 68.1 0.0 7.3e-19 68.1 0.0 1.7 2 0 0 2 2 2 1 SPRY domain TFIIA PF03153.13 KOS17305.1 - 0.057 13.4 14.3 0.083 12.9 14.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KOS17305.1 - 2.7 7.5 14.2 4.9 6.7 14.2 1.4 1 0 0 1 1 1 0 Spt20 family Metallophos PF00149.28 KOS17308.1 - 3.1e-19 70.3 0.2 5.1e-19 69.6 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase SAP PF02037.27 KOS17309.1 - 1.9e-13 49.8 0.2 4e-13 48.8 0.2 1.6 1 0 0 1 1 1 1 SAP domain Tho1_MOS11_C PF18592.1 KOS17309.1 - 1.6e-05 24.6 1.1 1.6e-05 24.6 1.1 2.4 2 0 0 2 2 2 1 Tho1/MOS11 C-terminal domain HeH PF12949.7 KOS17309.1 - 0.14 11.8 0.3 0.37 10.5 0.3 1.7 1 1 0 1 1 1 0 HeH/LEM domain Ribosomal_S3Ae PF01015.18 KOS17310.1 - 8.4e-89 296.5 2.4 1e-88 296.2 2.4 1.1 1 0 0 1 1 1 1 Ribosomal S3Ae family SUI1 PF01253.22 KOS17310.1 - 0.018 15.6 0.1 0.064 13.8 0.0 1.9 2 0 0 2 2 2 0 Translation initiation factor SUI1 Erythro-docking PF09277.11 KOS17310.1 - 0.042 13.7 0.2 13 5.8 0.1 2.5 2 0 0 2 2 2 0 Erythronolide synthase, docking Ribosomal_L22 PF00237.19 KOS17310.1 - 0.077 13.2 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e NEMO PF11577.8 KOS17310.1 - 0.086 12.9 0.8 0.55 10.3 0.0 2.3 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO Sec23_BS PF08033.12 KOS17311.1 - 6.7e-30 103.7 0.1 1.2e-29 102.8 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_trunk PF04811.15 KOS17311.1 - 1.3e-26 93.7 0.0 1.9e-26 93.1 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOS17311.1 - 1.8e-25 88.7 0.1 4.4e-25 87.5 0.1 1.7 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Gelsolin PF00626.22 KOS17311.1 - 4.7e-07 29.6 0.0 9.5e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Ribosomal_L11_N PF03946.14 KOS17312.1 - 6.1e-24 83.6 0.2 1e-23 82.9 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 KOS17312.1 - 2.5e-16 59.9 0.4 4.9e-16 59.0 0.4 1.5 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Myb_DNA-binding PF00249.31 KOS17313.1 - 1.3e-15 57.3 12.6 4.3e-08 33.2 0.9 2.5 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS17313.1 - 1.4e-13 50.9 7.6 2.9e-09 37.0 0.8 2.4 2 1 1 3 3 3 2 Myb-like DNA-binding domain HTH_Tnp_1 PF01527.20 KOS17313.1 - 0.025 14.9 1.3 0.042 14.2 1.3 1.4 1 0 0 1 1 1 0 Transposase Arg_decarbox_C PF17944.1 KOS17313.1 - 0.027 15.0 0.2 0.3 11.7 0.0 2.6 3 0 0 3 3 3 0 Arginine decarboxylase C-terminal helical extension DUF1178 PF06676.11 KOS17313.1 - 0.11 12.9 0.1 0.11 12.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) Sec39 PF08314.11 KOS17314.1 - 1.8e-50 172.3 2.0 2.2e-50 171.9 2.0 1.1 1 0 0 1 1 1 1 Secretory pathway protein Sec39 TAF6_C PF07571.13 KOS17314.1 - 0.15 12.4 0.0 1.8 8.9 0.1 2.1 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain RRM_1 PF00076.22 KOS17315.1 - 9e-20 70.3 0.0 1.6e-19 69.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS17315.1 - 0.00016 21.3 0.0 0.00023 20.7 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Aldedh PF00171.22 KOS17316.1 - 1.8e-118 396.0 2.3 2.3e-118 395.7 2.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Como_SCP PF02248.16 KOS17316.1 - 0.16 11.5 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 Small coat protein AAA PF00004.29 KOS17318.1 - 1.6e-41 141.8 0.0 4.2e-41 140.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 KOS17318.1 - 5.7e-27 93.5 0.1 2.2e-26 91.6 0.2 2.0 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 KOS17318.1 - 1.8e-16 59.9 5.7 1.8e-16 59.9 5.7 2.0 2 0 0 2 2 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 KOS17318.1 - 1.7e-07 30.9 0.0 6.3e-07 29.1 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 KOS17318.1 - 4.5e-07 29.7 0.0 8.1e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 KOS17318.1 - 1.5e-05 24.4 0.0 3.5e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_16 PF13191.6 KOS17318.1 - 1.7e-05 25.3 0.1 0.0022 18.4 0.0 2.8 2 1 0 3 3 3 1 AAA ATPase domain IstB_IS21 PF01695.17 KOS17318.1 - 3.4e-05 23.7 0.0 8.4e-05 22.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein RNA_helicase PF00910.22 KOS17318.1 - 7e-05 23.2 0.0 0.011 16.1 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_14 PF13173.6 KOS17318.1 - 7.8e-05 22.7 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS17318.1 - 9.1e-05 22.8 0.2 0.019 15.2 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 KOS17318.1 - 0.0001 22.3 0.0 0.00059 19.8 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 KOS17318.1 - 0.00015 21.0 0.1 0.00099 18.3 0.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 KOS17318.1 - 0.0006 19.6 1.3 0.0067 16.2 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS17318.1 - 0.0011 19.6 0.0 0.0038 17.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain PrkA PF06798.12 KOS17318.1 - 0.0016 18.2 0.1 0.0069 16.0 0.1 1.9 2 0 0 2 2 2 1 PrkA serine protein kinase C-terminal domain AAA_33 PF13671.6 KOS17318.1 - 0.0034 17.5 0.0 0.0094 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 KOS17318.1 - 0.009 16.1 0.0 0.027 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 KOS17318.1 - 0.019 15.4 0.0 0.07 13.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOS17318.1 - 0.024 14.2 0.1 0.13 11.8 0.0 2.3 2 1 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 KOS17318.1 - 0.024 14.2 0.0 0.33 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOS17318.1 - 0.028 13.8 0.0 0.082 12.3 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_21 PF13304.6 KOS17318.1 - 0.028 14.2 0.2 3.2 7.5 0.0 2.3 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system TPR_12 PF13424.6 KOS17318.1 - 0.049 13.9 0.9 0.083 13.2 0.3 1.7 2 0 0 2 2 1 0 Tetratricopeptide repeat PhoH PF02562.16 KOS17318.1 - 0.052 13.0 0.5 0.15 11.5 0.1 1.9 2 0 0 2 2 2 0 PhoH-like protein Use1 PF09753.9 KOS17318.1 - 0.052 13.3 1.8 0.082 12.6 1.8 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 Parvo_NS1 PF01057.17 KOS17318.1 - 0.11 11.6 0.0 0.19 10.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 NACHT PF05729.12 KOS17318.1 - 0.12 12.2 0.0 0.72 9.7 0.0 2.0 1 1 1 2 2 2 0 NACHT domain Torsin PF06309.11 KOS17318.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Torsin Cytidylate_kin PF02224.18 KOS17318.1 - 0.14 11.9 0.3 0.61 9.8 0.1 2.2 2 0 0 2 2 2 0 Cytidylate kinase TCTP PF00838.17 KOS17318.1 - 0.25 11.7 1.8 0.5 10.7 1.8 1.4 1 0 0 1 1 1 0 Translationally controlled tumour protein RrnaAD PF00398.20 KOS17319.1 - 2.6e-08 33.3 0.0 4.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase HHV-1_VABD PF16852.5 KOS17319.1 - 0.017 15.1 1.9 0.035 14.1 0.1 2.4 2 0 0 2 2 2 0 Herpes viral adaptor-to-host cellular mRNA binding domain Med11 PF10280.9 KOS17320.1 - 1.9e-45 154.7 0.3 2.9e-45 154.1 0.3 1.3 1 0 0 1 1 1 1 Mediator complex protein WD40 PF00400.32 KOS17321.1 - 3.1e-39 132.3 17.7 3.4e-07 30.9 0.3 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 KOS17321.1 - 2.6e-38 131.2 0.2 3.9e-38 130.6 0.2 1.2 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 KOS17321.1 - 1.7e-12 47.4 0.3 0.22 11.8 0.1 5.4 2 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS17321.1 - 0.00015 21.7 0.0 0.019 14.8 0.0 3.1 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A LisH PF08513.11 KOS17321.1 - 0.00071 19.4 0.1 0.002 18.0 0.0 1.8 2 0 0 2 2 2 1 LisH Ge1_WD40 PF16529.5 KOS17321.1 - 0.016 14.2 1.0 4.5 6.1 0.0 3.8 3 1 1 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein XTBD PF11952.8 KOS17321.1 - 0.083 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 XRN-Two Binding Domain, XTBD Nup160 PF11715.8 KOS17321.1 - 0.15 10.7 0.7 17 3.9 0.0 3.0 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Ytp1 PF10355.9 KOS17323.1 - 5.5e-66 222.6 19.9 5.5e-66 222.6 19.9 2.1 2 1 0 2 2 2 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 KOS17323.1 - 1.7e-30 104.9 0.4 1.7e-30 104.9 0.4 2.8 4 0 0 4 4 4 1 Domain of unknown function (DUF2427) Cytochrom_B561 PF03188.16 KOS17323.1 - 2.5e-05 24.4 2.7 2.5e-05 24.4 2.7 3.4 4 1 0 4 4 4 1 Eukaryotic cytochrome b561 JAB PF01398.21 KOS17324.1 - 7.7e-13 48.5 0.0 1.4e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 KOS17324.1 - 1.1e-09 38.4 0.0 2.6e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 KOS17324.1 - 0.00011 22.0 0.0 0.00028 20.6 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain Prefoldin_2 PF01920.20 KOS17325.1 - 2.2e-14 53.3 8.4 2.4e-14 53.1 8.4 1.1 1 0 0 1 1 1 1 Prefoldin subunit Uso1_p115_C PF04871.13 KOS17325.1 - 0.017 15.5 7.5 0.025 15.0 7.5 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region betaPIX_CC PF16523.5 KOS17325.1 - 0.05 13.4 4.8 0.069 13.0 4.1 1.7 1 1 1 2 2 2 0 betaPIX coiled coil Peptidase_S49_N PF08496.10 KOS17325.1 - 0.054 13.6 2.4 0.058 13.5 2.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DivIC PF04977.15 KOS17325.1 - 0.066 13.0 10.9 0.29 10.9 10.9 1.9 1 1 0 1 1 1 0 Septum formation initiator COX16 PF14138.6 KOS17325.1 - 0.73 10.4 4.9 2.6 8.6 4.9 1.9 1 1 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 60KD_IMP PF02096.20 KOS17325.1 - 1.2 9.0 3.8 1.4 8.8 3.8 1.3 1 1 0 1 1 1 0 60Kd inner membrane protein Apolipoprotein PF01442.18 KOS17326.1 - 0.0013 18.6 0.1 0.003 17.5 0.1 1.6 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain PH PF00169.29 KOS17326.1 - 0.0021 18.6 0.0 0.0035 17.8 0.0 1.4 1 0 0 1 1 1 1 PH domain TssC PF17541.2 KOS17326.1 - 0.13 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB SRP_TPR_like PF17004.5 KOS17327.1 - 7.8e-21 74.3 0.6 9.8e-20 70.7 0.6 2.2 2 0 0 2 2 2 1 Putative TPR-like repeat SRP72 PF08492.12 KOS17327.1 - 1.9e-16 60.2 7.2 1.9e-16 60.2 7.2 2.5 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_19 PF14559.6 KOS17327.1 - 1.1e-05 25.8 25.6 0.05 14.1 0.3 6.4 3 3 4 7 7 7 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS17327.1 - 2.7e-05 24.3 4.8 0.016 15.4 1.5 4.2 3 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KOS17327.1 - 5.3e-05 23.0 18.3 1.4 9.2 0.1 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat PPR PF01535.20 KOS17327.1 - 0.062 13.6 0.4 15 6.1 0.0 3.7 4 0 0 4 4 4 0 PPR repeat TPR_14 PF13428.6 KOS17327.1 - 0.12 13.3 31.0 3 8.9 0.4 8.5 8 2 1 9 9 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOS17327.1 - 1.9 8.7 15.7 0.37 11.0 0.3 5.3 4 2 2 6 6 6 0 Tetratricopeptide repeat TPR_3 PF07720.12 KOS17327.1 - 7.7 6.6 6.6 17 5.5 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TSKS PF15358.6 KOS17328.1 - 0.067 11.6 0.3 0.086 11.2 0.3 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate Sec7 PF01369.20 KOS17329.1 - 5.5e-29 101.2 0.0 8.5e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 KOS17329.1 - 2.5e-05 24.7 0.0 7.1e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 KOS17329.1 - 5.3e-05 23.6 0.0 0.00011 22.6 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Adaptin_N PF01602.20 KOS17330.1 - 1.2e-143 479.5 0.6 1.4e-143 479.2 0.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 KOS17330.1 - 1.8e-20 73.3 0.1 5.2e-20 71.8 0.1 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Cnd1 PF12717.7 KOS17330.1 - 2.8e-09 37.2 5.4 5.3e-05 23.3 0.0 4.5 3 2 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS17330.1 - 5.7e-08 33.1 1.3 0.0096 16.3 0.0 4.2 4 1 0 4 4 4 2 HEAT repeats DUF3730 PF12530.8 KOS17330.1 - 1.3e-05 24.9 0.0 7.7e-05 22.4 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3730) HEAT PF02985.22 KOS17330.1 - 0.0075 16.4 3.3 6.5 7.3 0.1 4.5 4 0 0 4 4 4 1 HEAT repeat RIX1 PF08167.12 KOS17330.1 - 0.032 14.0 0.0 0.25 11.0 0.0 2.5 2 2 0 2 2 2 0 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 KOS17330.1 - 0.038 14.2 0.4 3.5 7.8 0.0 3.7 3 2 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 KOS17330.1 - 0.065 13.8 1.7 48 4.6 0.0 4.6 4 1 1 5 5 5 0 HEAT-like repeat RICTOR_M PF14666.6 KOS17330.1 - 0.096 12.5 0.8 0.32 10.8 0.0 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain Cohesin_HEAT PF12765.7 KOS17330.1 - 0.26 11.6 0.9 0.55 10.6 0.2 2.0 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion zf-rbx1 PF12678.7 KOS17331.1 - 1.9e-09 37.6 7.2 3.5e-09 36.8 7.2 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOS17331.1 - 2.2e-08 34.3 7.3 4.4e-08 33.3 7.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOS17331.1 - 6.4e-06 25.9 2.9 0.00023 21.0 0.7 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS17331.1 - 1.6e-05 24.9 3.1 3.2e-05 23.9 3.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS17331.1 - 4e-05 23.5 3.1 0.0001 22.2 3.2 1.7 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOS17331.1 - 9.4e-05 22.2 5.1 0.00021 21.1 5.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOS17331.1 - 0.00028 20.9 1.4 0.00061 19.8 1.4 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOS17331.1 - 0.00056 19.5 0.3 0.0014 18.3 0.3 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 KOS17331.1 - 0.001 18.9 1.9 0.001 18.9 1.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOS17331.1 - 0.004 17.0 5.6 0.024 14.5 5.7 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOS17331.1 - 0.12 12.6 1.0 0.27 11.4 1.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 KOS17331.1 - 0.19 11.5 2.1 0.26 11.1 0.4 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 KOS17331.1 - 0.79 9.5 2.5 4 7.3 2.5 2.2 1 1 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 KOS17331.1 - 2.5 8.3 4.3 9.2 6.5 4.3 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain Peptidase_M14 PF00246.24 KOS17332.1 - 4.9e-42 144.7 0.0 6.2e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase MAPEG PF01124.18 KOS17333.1 - 1.6e-22 79.8 3.4 1.8e-22 79.6 3.4 1.1 1 0 0 1 1 1 1 MAPEG family Clathrin_lg_ch PF01086.17 KOS17334.1 - 6.8e-74 248.8 5.7 7.6e-74 248.6 5.7 1.0 1 0 0 1 1 1 1 Clathrin light chain Methyltr_RsmF_N PF17125.5 KOS17334.1 - 0.14 12.6 0.2 14 6.3 0.0 2.4 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF Ku_C PF03730.14 KOS17334.1 - 1 10.1 6.0 3.1 8.6 6.1 1.8 1 1 0 1 1 1 0 Ku70/Ku80 C-terminal arm CTD_bind PF04818.13 KOS17335.1 - 3.5e-16 59.8 0.2 1e-15 58.3 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase II-binding domain. COX7a PF02238.15 KOS17336.1 - 3.7e-21 75.3 2.0 4.2e-21 75.1 2.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII Cation_efflux PF01545.21 KOS17337.1 - 2.7e-17 63.1 4.9 3.6e-17 62.8 4.9 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KOS17337.1 - 4.5e-10 39.5 0.2 4.5e-10 39.5 0.2 1.7 2 0 0 2 2 2 1 Dimerisation domain of Zinc Transporter Glyco_transf_8 PF01501.20 KOS17338.1 - 7.9e-22 78.0 1.2 2.2e-20 73.3 1.2 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 KOS17338.1 - 0.014 14.8 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative Vps5 PF09325.10 KOS17340.1 - 3e-87 292.1 3.5 3e-87 292.1 3.5 1.4 2 0 0 2 2 2 1 Vps5 C terminal like PX PF00787.24 KOS17340.1 - 1.5e-24 86.2 0.2 3.3e-24 85.1 0.0 1.7 2 0 0 2 2 2 1 PX domain BAR_3 PF16746.5 KOS17340.1 - 0.00035 20.4 7.0 0.058 13.1 2.0 2.6 1 1 1 2 2 2 2 BAR domain of APPL family BAR_2 PF10455.9 KOS17340.1 - 0.0025 17.0 1.4 0.0039 16.4 1.4 1.4 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR_3_WASP_bdg PF10456.9 KOS17340.1 - 0.0036 16.8 0.3 0.0066 15.9 0.3 1.5 1 0 0 1 1 1 1 WASP-binding domain of Sorting nexin protein BAR PF03114.18 KOS17340.1 - 0.027 14.1 8.2 0.023 14.3 6.6 1.6 2 0 0 2 2 2 0 BAR domain DUF713 PF05218.14 KOS17340.1 - 0.064 13.0 2.1 0.13 11.9 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) DUF3450 PF11932.8 KOS17340.1 - 0.14 11.5 4.1 0.3 10.3 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4805 PF16063.5 KOS17340.1 - 2.6 7.3 10.8 6.3 6.0 10.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) DnaJ PF00226.31 KOS17341.1 - 1.8e-19 69.6 4.5 2.1e-19 69.4 2.0 2.4 2 0 0 2 2 2 1 DnaJ domain AdoMetDC_leader PF08132.11 KOS17341.1 - 1.5 8.8 10.6 0.17 11.8 3.4 3.0 3 0 0 3 3 3 0 S-adenosyl-l-methionine decarboxylase leader peptide Metallophos PF00149.28 KOS17342.1 - 2.3e-10 41.3 2.5 1.1e-09 39.2 2.5 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOS17342.1 - 3.7e-06 27.2 0.8 0.0057 16.9 0.3 2.5 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain FAM176 PF14851.6 KOS17342.1 - 0.11 12.2 2.5 0.16 11.6 0.2 2.0 2 0 0 2 2 2 0 FAM176 family HSP90 PF00183.18 KOS17344.1 - 2.4e-220 732.9 32.6 3e-220 732.5 32.6 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 KOS17344.1 - 2e-15 57.3 0.1 3.8e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOS17344.1 - 3.8e-10 39.7 0.1 1.2e-09 38.1 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF1676 PF07898.13 KOS17344.1 - 0.17 11.9 3.1 0.23 11.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) LOH1CR12 PF10158.9 KOS17344.1 - 0.62 10.1 4.6 0.16 12.0 0.3 2.2 2 0 0 2 2 2 0 Tumour suppressor protein Vfa1 PF08432.10 KOS17344.1 - 3.7 7.9 20.0 2.8 8.3 11.6 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Flavin_Reduct PF01613.18 KOS17345.1 - 9e-31 107.0 0.0 1.2e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain DUF4554 PF15091.6 KOS17346.1 - 0.27 10.1 2.1 0.63 8.9 2.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) GST_N PF02798.20 KOS17347.1 - 1.1e-13 51.3 0.0 4.9e-09 36.4 0.0 2.6 3 0 0 3 3 3 2 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOS17347.1 - 1.2e-12 48.1 0.0 3.7e-11 43.3 0.0 2.4 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOS17347.1 - 1.5e-10 41.2 0.0 3.4e-10 40.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOS17347.1 - 2.5e-09 37.0 0.3 6.1e-09 35.8 0.1 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOS17347.1 - 3.1e-08 33.7 0.0 5.9e-08 32.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS17347.1 - 2.2e-07 31.0 0.1 1.2e-06 28.6 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain H2TH PF06831.14 KOS17348.1 - 4.5e-24 84.3 0.0 6.7e-24 83.7 0.0 1.2 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase H2TH domain Fapy_DNA_glyco PF01149.24 KOS17348.1 - 2.1e-10 41.2 0.1 4.5e-10 40.1 0.0 1.6 2 0 0 2 2 2 1 Formamidopyrimidine-DNA glycosylase N-terminal domain FbpA PF05833.11 KOS17348.1 - 0.042 12.6 0.0 0.049 12.4 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Acetyltransf_1 PF00583.25 KOS17349.1 - 5.3e-15 55.7 0.0 7.7e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS17349.1 - 5.9e-12 45.6 0.0 9e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS17349.1 - 1.5e-10 41.4 0.0 2.1e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS17349.1 - 5.5e-08 32.7 0.0 9.2e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 KOS17349.1 - 0.0019 18.3 0.0 0.0027 17.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOS17349.1 - 0.0024 18.0 0.1 0.0048 17.0 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 KOS17349.1 - 0.087 12.6 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ ATG16 PF08614.11 KOS17350.1 - 0.21 11.8 6.9 0.57 10.4 6.9 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2838 PF10998.8 KOS17351.1 - 2.5e-45 153.2 7.8 2.5e-45 153.2 7.8 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2838) Apolipoprotein PF01442.18 KOS17351.1 - 0.057 13.3 3.5 0.099 12.5 3.5 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DHR10 PF18595.1 KOS17351.1 - 0.2 11.7 3.8 0.43 10.6 3.8 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Atg14 PF10186.9 KOS17351.1 - 2.6 7.0 4.7 3.9 6.5 4.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Dicty_CAR PF05462.11 KOS17353.1 - 1e-10 41.3 5.7 1e-10 41.3 5.7 1.6 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 KOS17353.1 - 1.5e-10 40.8 1.0 1.5e-10 40.8 1.0 1.6 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 KOS17353.1 - 8.6e-09 35.1 1.8 1.2e-08 34.6 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 KOS17353.1 - 5.8e-06 26.2 6.8 5.8e-06 26.2 6.8 1.7 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 STE3 PF02076.15 KOS17353.1 - 0.0013 18.0 2.4 0.0013 18.0 2.4 3.0 2 1 1 3 3 3 1 Pheromone A receptor 7TM_GPCR_Srsx PF10320.9 KOS17353.1 - 0.0027 17.1 0.9 0.0047 16.4 0.9 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx Frizzled PF01534.17 KOS17353.1 - 0.0089 15.1 9.3 7.1 5.6 9.3 2.2 1 1 0 1 1 1 1 Frizzled/Smoothened family membrane region CitMHS PF03600.16 KOS17353.1 - 0.016 14.5 0.5 0.021 14.0 0.5 1.2 1 0 0 1 1 1 0 Citrate transporter DUF2721 PF11026.8 KOS17353.1 - 0.048 13.6 2.4 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) BatD PF13584.6 KOS17353.1 - 0.17 10.6 0.1 0.17 10.6 0.1 1.7 2 0 0 2 2 2 0 Oxygen tolerance GIT1_C PF12205.8 KOS17354.1 - 0.13 12.4 0.4 0.29 11.3 0.4 1.5 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term Jnk-SapK_ap_N PF09744.9 KOS17354.1 - 2.3 8.4 10.4 4.3 7.5 6.5 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 FAD_binding_1 PF00667.20 KOS17356.1 - 6.9e-46 156.6 0.0 9.7e-46 156.1 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOS17356.1 - 8.8e-11 42.4 0.1 6.2e-10 39.7 0.0 2.4 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain PS_Dcarbxylase PF02666.15 KOS17357.1 - 3.3e-76 255.3 0.0 5.4e-75 251.3 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl PF00364.22 KOS17357.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Biotin-requiring enzyme NADH_oxidored PF08040.11 KOS17357.1 - 0.076 12.7 0.2 0.6 9.8 0.0 2.5 3 0 0 3 3 3 0 MNLL subunit Peptidase_C12 PF01088.21 KOS17358.1 - 1.7e-63 214.2 0.0 2.1e-63 213.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 UCH_C PF18031.1 KOS17358.1 - 9.9e-10 38.2 0.1 2.4e-09 37.0 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolases Xan_ur_permease PF00860.20 KOS17359.1 - 1.6e-25 89.6 30.7 1.8e-14 53.3 8.4 2.2 2 0 0 2 2 2 2 Permease family MFS_MOT1 PF16983.5 KOS17359.1 - 0.0043 17.4 4.3 0.0043 17.4 4.3 3.0 2 0 0 2 2 2 1 Molybdate transporter of MFS superfamily N2227 PF07942.12 KOS17360.1 - 3.6e-87 292.0 0.0 2.1e-76 256.7 0.0 2.1 2 0 0 2 2 2 2 N2227-like protein Methyltransf_23 PF13489.6 KOS17360.1 - 0.035 13.9 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17360.1 - 0.061 14.0 0.1 0.17 12.5 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17360.1 - 0.12 13.1 0.0 0.63 10.8 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase domain PAC4 PF16093.5 KOS17361.1 - 3.5e-21 75.2 0.3 4.8e-21 74.7 0.3 1.2 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 POC3_POC4 PF10448.9 KOS17361.1 - 0.12 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 20S proteasome chaperone assembly proteins 3 and 4 ABC_membrane PF00664.23 KOS17363.1 - 5.7e-49 167.2 9.9 7.4e-49 166.8 9.9 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOS17363.1 - 7e-34 117.3 0.0 2e-33 115.8 0.0 1.8 1 0 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KOS17363.1 - 6.4e-05 23.2 0.0 0.00028 21.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 KOS17363.1 - 0.001 18.5 2.6 0.0092 15.4 0.1 2.2 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA PF00004.29 KOS17363.1 - 0.0016 18.9 0.0 0.017 15.5 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOS17363.1 - 0.0059 17.0 0.1 0.018 15.4 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 KOS17363.1 - 0.016 14.9 0.0 0.042 13.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 KOS17363.1 - 0.023 14.7 0.1 0.089 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SbcCD_C PF13558.6 KOS17363.1 - 0.04 14.2 1.5 0.72 10.1 1.5 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit IstB_IS21 PF01695.17 KOS17363.1 - 0.051 13.3 0.2 0.48 10.1 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 KOS17363.1 - 0.071 11.9 0.3 0.14 10.9 0.1 1.5 2 0 0 2 2 2 0 Predicted ATPase of the ABC class DEAD PF00270.29 KOS17363.1 - 0.13 12.0 0.1 0.85 9.4 0.1 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_18 PF13238.6 KOS17363.1 - 0.13 12.8 0.1 0.39 11.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 KOS17363.1 - 0.15 12.2 0.0 1.5 8.9 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain Hydrolase_4 PF12146.8 KOS17364.1 - 2.4e-49 167.7 0.0 3.1e-49 167.4 0.0 1.0 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS17364.1 - 4.1e-15 56.1 0.0 2.2e-13 50.4 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS17364.1 - 1.1e-14 55.6 1.6 1.4e-14 55.3 1.6 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 KOS17364.1 - 0.011 15.2 0.1 2.2 7.7 0.0 2.5 2 1 1 3 3 3 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 KOS17364.1 - 0.016 14.2 0.0 0.026 13.4 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 KOS17364.1 - 0.034 14.0 0.2 0.16 11.8 0.2 1.9 1 1 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 KOS17364.1 - 0.087 12.5 0.1 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 Putative esterase Atx10homo_assoc PF09759.9 KOS17365.1 - 4.2e-12 46.0 0.0 1.2e-11 44.5 0.0 1.8 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain CSN4_RPN5_eIF3a PF18420.1 KOS17365.1 - 0.13 12.4 0.0 0.49 10.6 0.0 1.9 1 0 0 1 1 1 0 CSN4/RPN5/eIF3a helix turn helix domain PNP_UDP_1 PF01048.20 KOS17366.1 - 1.5e-38 132.4 0.5 1.8e-38 132.1 0.5 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DUF2694 PF10904.8 KOS17366.1 - 0.041 14.0 0.0 0.086 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2694) AA_permease_2 PF13520.6 KOS17367.1 - 4.2e-78 263.1 21.7 5e-78 262.8 21.7 1.0 1 0 0 1 1 1 1 Amino acid permease Arrestin_C PF02752.22 KOS17370.1 - 6.5e-06 26.6 0.0 8.6e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Ras PF00071.22 KOS17371.1 - 2e-22 79.5 0.0 6.6e-15 55.1 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KOS17371.1 - 1.2e-13 51.4 0.0 8.8e-09 35.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 KOS17371.1 - 3.2e-08 33.7 0.0 0.00069 19.7 0.0 3.1 2 1 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOS17371.1 - 8.5e-08 32.4 0.0 0.0015 18.6 0.1 3.0 2 1 1 3 3 3 2 Dynamin family EF_assoc_2 PF08356.12 KOS17371.1 - 2.2e-05 24.4 0.0 4.5e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 EF hand associated AAA_22 PF13401.6 KOS17371.1 - 3.6e-05 24.0 0.0 0.0097 16.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOS17371.1 - 5.1e-05 22.9 0.0 0.0048 16.6 0.0 2.4 2 0 0 2 2 2 1 P-loop containing region of AAA domain EF-hand_7 PF13499.6 KOS17371.1 - 0.00011 22.5 0.1 0.00028 21.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair GTP_EFTU PF00009.27 KOS17371.1 - 0.00014 21.4 0.0 3.2 7.3 0.0 3.2 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS17371.1 - 0.00035 20.5 0.0 1.9 8.4 0.0 3.3 3 0 0 3 3 3 1 RsgA GTPase EF-hand_1 PF00036.32 KOS17371.1 - 0.00046 19.5 0.0 0.0014 18.0 0.0 1.8 1 0 0 1 1 1 1 EF hand AAA_28 PF13521.6 KOS17371.1 - 0.00051 20.3 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOS17371.1 - 0.00051 20.5 0.0 0.11 12.9 0.0 2.8 3 0 0 3 3 3 1 AAA ATPase domain EF-hand_6 PF13405.6 KOS17371.1 - 0.0053 16.6 0.1 0.013 15.3 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain ABC_tran PF00005.27 KOS17371.1 - 0.006 17.1 0.0 0.38 11.3 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_24 PF13479.6 KOS17371.1 - 0.0094 15.7 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain EF-hand_10 PF14788.6 KOS17371.1 - 0.039 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 EF hand Septin PF00735.18 KOS17371.1 - 0.05 12.9 0.0 0.56 9.4 0.0 2.1 2 0 0 2 2 2 0 Septin DUF815 PF05673.13 KOS17371.1 - 0.057 12.6 0.0 6.3 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 KOS17371.1 - 0.068 13.6 0.0 14 6.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 KOS17371.1 - 0.069 13.3 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 KOS17371.1 - 0.083 12.7 0.0 0.33 10.7 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Ploopntkinase3 PF18751.1 KOS17371.1 - 0.13 12.1 0.0 2.1 8.2 0.0 2.2 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 EF-hand_5 PF13202.6 KOS17371.1 - 0.17 11.5 0.0 0.48 10.0 0.0 1.8 1 0 0 1 1 1 0 EF hand AAA_15 PF13175.6 KOS17371.1 - 0.2 11.3 0.0 7.9 6.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 KOS17371.1 - 0.23 11.9 0.1 1.2 9.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Pox_MCEL PF03291.16 KOS17372.1 - 2.1e-67 227.6 0.0 2.7e-45 155.0 0.0 2.4 2 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 KOS17372.1 - 3.3e-09 37.3 0.0 0.00011 22.9 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17372.1 - 4.9e-09 36.8 0.0 0.007 17.1 0.0 2.8 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOS17372.1 - 8.5e-07 28.9 0.0 1.6e-06 28.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS17372.1 - 3.3e-06 27.0 0.0 0.00036 20.4 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17372.1 - 6.8e-06 26.6 0.0 0.091 13.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Raftlin PF15250.6 KOS17372.1 - 0.00047 19.0 3.5 0.0014 17.4 0.1 2.0 2 0 0 2 2 2 1 Raftlin NNMT_PNMT_TEMT PF01234.17 KOS17372.1 - 0.04 13.1 0.0 0.062 12.5 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_4 PF02390.17 KOS17372.1 - 0.1 12.1 0.0 0.26 10.7 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase RPN7 PF10602.9 KOS17373.1 - 1.3e-54 184.5 0.4 2.6e-54 183.5 0.4 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 KOS17373.1 - 9.1e-15 55.1 0.0 2.8e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 PCI domain ABC_tran_Xtn PF12848.7 KOS17373.1 - 4.2 7.5 7.1 13 5.9 0.0 3.4 3 0 0 3 3 3 0 ABC transporter Acetyltransf_1 PF00583.25 KOS17374.1 - 5.5e-07 29.8 0.7 2.9e-06 27.5 0.7 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOS17374.1 - 1.8e-05 25.0 0.6 0.00081 19.8 0.1 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOS17374.1 - 0.0035 18.0 0.2 0.021 15.5 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS17374.1 - 0.056 13.4 0.0 0.17 11.8 0.0 1.7 1 1 0 2 2 2 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS17374.1 - 0.074 13.0 0.1 0.24 11.4 0.0 1.8 2 0 0 2 2 2 0 FR47-like protein Bac_surface_Ag PF01103.23 KOS17376.1 - 3.6e-36 125.3 0.0 4.7e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Surface antigen ABC2_membrane PF01061.24 KOS17377.1 - 7.8e-95 316.2 49.4 8.7e-49 165.8 20.0 2.8 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOS17377.1 - 8.6e-34 117.0 0.0 8.4e-17 62.0 0.0 3.5 3 1 1 4 4 4 2 ABC transporter PDR_CDR PF06422.12 KOS17377.1 - 2.6e-31 107.3 6.9 6.1e-29 99.8 0.0 3.5 3 0 0 3 3 3 2 CDR ABC transporter ABC_trans_N PF14510.6 KOS17377.1 - 6.1e-17 62.0 0.0 2.1e-16 60.3 0.0 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 KOS17377.1 - 1.3e-06 28.9 0.4 0.0012 19.2 0.1 2.8 3 0 0 3 3 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOS17377.1 - 1.2e-05 25.3 0.1 0.0013 18.7 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_25 PF13481.6 KOS17377.1 - 5.8e-05 22.7 0.0 0.001 18.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS17377.1 - 0.00018 22.0 0.0 0.053 14.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOS17377.1 - 0.00019 21.1 0.4 0.029 14.1 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_33 PF13671.6 KOS17377.1 - 0.00023 21.3 0.0 0.23 11.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 KOS17377.1 - 0.0003 20.7 0.0 0.83 9.4 0.0 2.6 3 0 0 3 3 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOS17377.1 - 0.0014 18.9 0.1 0.3 11.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 KOS17377.1 - 0.0067 16.4 0.1 2.7 7.9 0.0 2.7 2 0 0 2 2 2 1 NACHT domain cobW PF02492.19 KOS17377.1 - 0.0088 15.6 0.4 0.16 11.6 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_17 PF13207.6 KOS17377.1 - 0.015 15.8 0.1 8.7 6.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOS17377.1 - 0.018 15.5 0.0 2.9 8.3 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PepSY_TM PF03929.16 KOS17377.1 - 0.023 14.4 0.2 1.3 8.6 0.0 2.9 2 1 0 2 2 2 0 PepSY-associated TM region AAA_30 PF13604.6 KOS17377.1 - 0.023 14.4 0.0 5.3 6.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 KOS17377.1 - 0.045 13.2 0.0 8.5 5.7 0.0 3.4 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOS17377.1 - 0.11 13.0 0.5 0.23 12.0 0.1 1.6 2 0 0 2 2 1 0 AAA domain PHO4 PF01384.20 KOS17377.1 - 0.19 10.7 7.9 0.23 10.5 2.5 2.2 2 0 0 2 2 2 0 Phosphate transporter family AAA_24 PF13479.6 KOS17377.1 - 0.21 11.3 0.6 13 5.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 KOS17377.1 - 1 8.4 45.3 0.092 11.8 13.6 3.4 2 1 2 4 4 4 0 ABC-2 family transporter protein UvrD-helicase PF00580.21 KOS17378.1 - 3.3e-64 217.4 0.2 4.2e-63 213.8 0.2 2.3 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 KOS17378.1 - 1.3e-62 212.2 0.0 1.4e-61 208.9 0.0 2.1 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 KOS17378.1 - 2.7e-31 108.9 1.6 3.2e-31 108.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 KOS17378.1 - 6.4e-15 54.7 0.1 2.2e-14 53.0 0.1 2.0 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 KOS17378.1 - 1.7e-08 34.4 6.8 5.7e-06 26.2 0.3 2.9 3 0 0 3 3 3 2 AAA domain Viral_helicase1 PF01443.18 KOS17378.1 - 0.00015 21.6 0.0 1.1 9.0 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_12 PF13087.6 KOS17378.1 - 0.0016 18.1 0.0 0.007 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOS17378.1 - 0.031 14.1 1.5 0.29 10.9 1.5 2.7 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOS17378.1 - 0.18 12.1 2.2 1.4 9.2 0.4 3.2 2 1 0 2 2 2 0 AAA domain CcmD PF04995.14 KOS17379.1 - 0.18 11.9 3.5 0.29 11.3 0.2 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) DUF2014 PF09427.10 KOS17380.1 - 2.5e-70 236.8 5.6 1e-68 231.6 5.4 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2014) Pectate_lyase_3 PF12708.7 KOS17381.1 - 2.9e-38 131.9 6.3 1.3e-26 93.8 1.8 2.5 2 0 0 2 2 2 2 Pectate lyase superfamily protein ESCRT-II PF05871.12 KOS17382.1 - 9.5e-51 171.7 0.0 1.2e-50 171.3 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit RTT107_BRCT_5 PF16770.5 KOS17383.1 - 3.7e-34 116.6 0.0 1.5e-32 111.5 0.0 3.2 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 KOS17383.1 - 2.6e-29 100.9 0.3 2.6e-20 72.1 0.1 4.6 4 0 0 4 4 4 3 twin BRCT domain BRCT PF00533.26 KOS17383.1 - 6.9e-26 90.4 0.0 1.2e-09 38.4 0.0 5.7 6 0 0 6 6 6 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOS17383.1 - 2.5e-18 66.3 0.0 1.1e-05 25.7 0.0 5.7 6 0 0 6 6 6 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KOS17383.1 - 1.1e-07 32.1 0.0 0.43 10.9 0.0 3.7 3 0 0 3 3 3 3 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 KOS17383.1 - 1.6e-06 28.1 0.0 0.0049 16.9 0.0 2.9 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain NOA36 PF06524.12 KOS17383.1 - 2 7.7 8.7 3.8 6.7 8.7 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 KOS17383.1 - 3.9 5.4 4.6 5.9 4.9 4.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 KOS17383.1 - 7.8 7.0 12.3 14 6.1 11.5 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Hexokinase_2 PF03727.16 KOS17384.1 - 9.4e-57 192.2 0.0 1.3e-56 191.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 KOS17384.1 - 8.9e-40 136.7 0.0 1.3e-39 136.2 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Glucosamine_iso PF01182.20 KOS17385.1 - 6.4e-21 75.3 0.0 1e-20 74.6 0.0 1.3 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Foie-gras_1 PF11817.8 KOS17386.1 - 5.2e-87 291.7 2.9 1.6e-80 270.4 3.9 2.2 2 0 0 2 2 2 2 Foie gras liver health family 1 Gryzun PF07919.12 KOS17387.1 - 3.6e-183 610.5 0.0 4.1e-183 610.4 0.0 1.0 1 0 0 1 1 1 1 Gryzun, putative trafficking through Golgi Gryzun-like PF12742.7 KOS17387.1 - 0.0018 18.2 0.0 0.0037 17.2 0.0 1.6 1 0 0 1 1 1 1 Gryzun, putative Golgi trafficking Pkinase PF00069.25 KOS17388.1 - 3.1e-55 187.4 0.0 4e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17388.1 - 5.1e-30 104.6 0.0 6.5e-30 104.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOS17388.1 - 0.0019 17.6 0.0 0.003 16.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS17388.1 - 0.0064 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOS17388.1 - 0.0067 15.2 0.0 0.011 14.5 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS17388.1 - 0.057 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family AAA PF00004.29 KOS17389.1 - 2.3e-17 63.7 0.0 3.8e-17 62.9 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TFA2_Winged_2 PF18121.1 KOS17390.1 - 3.4e-22 77.9 0.0 6.1e-22 77.1 0.0 1.5 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 KOS17390.1 - 1.2e-10 41.5 0.0 2.6e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 TFIIE beta subunit core domain Cyt-b5 PF00173.28 KOS17391.1 - 1.1e-22 80.0 0.2 1.8e-22 79.2 0.2 1.4 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain U62_UL91 PF17442.2 KOS17391.1 - 0.039 13.9 0.0 0.08 12.9 0.0 1.4 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins zf-H2C2_2 PF13465.6 KOS17392.1 - 8.9e-07 29.1 1.9 8.9e-07 29.1 1.9 4.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2 PF00096.26 KOS17392.1 - 6.7e-06 26.3 10.4 0.0001 22.6 4.4 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS17392.1 - 0.013 16.2 2.7 0.013 16.2 2.7 2.8 3 0 0 3 3 3 0 C2H2-type zinc finger Ntox47 PF15540.6 KOS17392.1 - 0.14 12.5 0.1 0.28 11.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial toxin 47 Nramp PF01566.18 KOS17393.1 - 2.2e-90 303.2 24.9 6.3e-90 301.7 23.4 2.3 2 1 0 2 2 2 1 Natural resistance-associated macrophage protein VHS PF00790.19 KOS17394.1 - 1.1e-19 70.7 0.0 1.9e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 VHS domain GAT PF03127.14 KOS17394.1 - 6.1e-08 32.9 0.3 1.4e-07 31.7 0.3 1.6 1 0 0 1 1 1 1 GAT domain RXT2_N PF08595.11 KOS17395.1 - 1.1e-46 158.7 0.0 1.1e-46 158.7 0.0 2.4 3 0 0 3 3 3 1 RXT2-like, N-terminal NUC153 PF08159.12 KOS17396.1 - 7.9e-12 44.8 1.3 1.4e-11 44.0 1.3 1.4 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 KOS17396.1 - 3.6e-07 30.8 0.2 0.053 14.4 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17396.1 - 0.0043 17.3 0.0 0.021 15.1 0.0 2.1 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Aminotran_1_2 PF00155.21 KOS17397.1 - 8.2e-39 133.8 0.0 1.1e-38 133.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Sugar_tr PF00083.24 KOS17398.1 - 9.4e-44 150.0 21.8 1.2e-43 149.6 21.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17398.1 - 6.3e-16 58.3 26.1 1e-15 57.5 25.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily NMO PF03060.15 KOS17399.1 - 1.6e-56 192.2 1.9 1.6e-55 188.8 1.9 1.9 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 KOS17399.1 - 1.9e-09 37.0 1.0 1.5e-06 27.5 1.0 2.3 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOS17399.1 - 0.0013 17.8 0.3 0.0022 17.1 0.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase F-box-like PF12937.7 KOS17400.1 - 0.0022 17.8 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like Med13_C PF06333.12 KOS17401.1 - 5.2e-43 147.6 2.1 5.8e-43 147.4 2.1 1.0 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain An_peroxidase PF03098.15 KOS17402.1 - 5.4e-41 140.8 0.1 6.9e-14 51.3 0.0 4.0 2 1 1 3 3 3 3 Animal haem peroxidase p450 PF00067.22 KOS17402.1 - 0.028 13.2 0.0 0.045 12.5 0.0 1.2 1 0 0 1 1 1 0 Cytochrome P450 E1-E2_ATPase PF00122.20 KOS17404.1 - 4.6e-36 124.0 0.9 4.6e-36 124.0 0.9 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOS17404.1 - 2.5e-33 115.3 7.6 2.5e-33 115.3 7.6 2.6 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOS17404.1 - 4.7e-26 92.4 0.7 3.5e-20 73.2 0.1 2.6 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS17404.1 - 1.6e-11 44.1 0.0 3.1e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOS17404.1 - 3.1e-09 36.4 0.0 1.5e-08 34.2 0.0 2.3 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS17404.1 - 3.7e-05 23.6 0.5 6.9e-05 22.7 0.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS17404.1 - 0.014 15.8 0.0 0.065 13.6 0.0 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DUF2157 PF09925.9 KOS17404.1 - 0.056 13.2 0.0 0.056 13.2 0.0 3.4 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) DUF2231 PF09990.9 KOS17404.1 - 1.7 9.1 6.5 0.61 10.5 2.1 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2231) DUF3262 PF11660.8 KOS17404.1 - 4.2 7.8 9.1 4.3 7.8 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) Acetyltransf_1 PF00583.25 KOS17405.1 - 3.5e-07 30.5 0.6 7.9e-07 29.3 0.1 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS17405.1 - 0.0011 18.9 0.2 0.0025 17.8 0.1 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS17405.1 - 0.0017 18.8 0.1 0.007 16.8 0.0 2.0 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain CBP PF12192.8 KOS17405.1 - 0.026 14.7 0.8 0.058 13.6 0.8 1.6 1 0 0 1 1 1 0 Fungal calcium binding protein Acetyltransf_3 PF13302.7 KOS17405.1 - 0.032 14.9 0.2 0.22 12.2 0.3 1.9 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain SET PF00856.28 KOS17406.1 - 0.0014 19.1 0.0 0.3 11.4 0.0 2.2 1 1 1 2 2 2 2 SET domain MOZ_SAS PF01853.18 KOS17407.1 - 2.1e-75 252.3 0.0 2.9e-75 251.9 0.0 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOS17407.1 - 1.2e-20 72.8 3.4 2.5e-20 71.8 3.4 1.6 1 0 0 1 1 1 1 MYST family zinc finger domain Collagen PF01391.18 KOS17407.1 - 2e-06 27.4 6.8 2e-06 27.4 6.8 2.3 2 0 0 2 2 2 1 Collagen triple helix repeat (20 copies) Acetyltransf_7 PF13508.7 KOS17407.1 - 0.073 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ATG13 PF10033.9 KOS17408.1 - 1.8e-65 221.0 0.1 8.2e-56 189.4 0.1 2.3 1 1 1 2 2 2 2 Autophagy-related protein 13 BTB PF00651.31 KOS17409.1 - 1e-07 32.1 0.0 2.5e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 BTB/POZ domain Mito_carr PF00153.27 KOS17410.1 - 4.8e-67 221.9 1.5 4e-25 87.5 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Pept_tRNA_hydro PF01195.19 KOS17410.1 - 0.034 14.1 0.0 0.81 9.6 0.0 2.1 1 1 0 2 2 2 0 Peptidyl-tRNA hydrolase Serine_protease PF18405.1 KOS17410.1 - 0.11 11.7 0.4 9 5.4 0.0 3.2 3 1 0 3 3 3 0 Gammaproteobacterial serine protease Tim17 PF02466.19 KOS17410.1 - 0.24 11.8 1.4 0.97 9.8 1.4 2.2 1 1 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family ENTH PF01417.20 KOS17412.1 - 1.3e-11 44.7 0.0 1.5e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 ENTH domain ENTH PF01417.20 KOS17413.1 - 3.2e-29 101.5 0.3 5.4e-29 100.8 0.3 1.4 1 0 0 1 1 1 1 ENTH domain UIM PF02809.20 KOS17413.1 - 0.00022 20.9 1.9 0.0078 16.1 0.2 3.1 2 0 0 2 2 2 1 Ubiquitin interaction motif DUF1720 PF08226.11 KOS17413.1 - 0.0029 18.0 28.9 0.0029 18.0 28.9 5.2 1 1 2 3 3 3 1 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 KOS17414.1 - 3.4e-18 65.8 2.9 3.8e-13 49.7 3.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 KOS17414.1 - 9.7e-14 49.8 7.4 2.6e-05 23.5 0.2 3.3 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOS17414.1 - 8.7e-13 47.9 10.2 4.3e-11 42.5 2.9 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOS17414.1 - 3e-12 45.4 4.1 0.0005 19.8 0.2 3.3 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 KOS17414.1 - 5.3e-08 32.0 2.8 0.00023 20.5 0.1 3.4 3 0 0 3 3 3 2 EF hand EF-hand_9 PF14658.6 KOS17414.1 - 6e-05 23.3 0.2 0.00075 19.8 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain UPF0492 PF15744.5 KOS17414.1 - 0.077 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 Nup96 PF12110.8 KOS17415.1 - 1.9e-91 306.3 0.3 2.7e-91 305.7 0.3 1.2 1 0 0 1 1 1 1 Nuclear protein 96 Nucleoporin2 PF04096.14 KOS17415.1 - 5.1e-52 175.9 0.0 8.1e-52 175.3 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nucleoporin_FG PF13634.6 KOS17415.1 - 3.5e-23 82.2 314.5 7.4e-10 39.5 40.0 10.0 4 3 6 10 10 10 7 Nucleoporin FG repeat region Thiolase_N PF00108.23 KOS17416.1 - 6.2e-65 219.1 1.0 8.7e-65 218.7 1.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS17416.1 - 3e-36 123.8 6.3 3.1e-36 123.7 3.3 2.2 2 0 0 2 2 2 1 Thiolase, C-terminal domain Not1 PF04054.15 KOS17417.1 - 1.7e-100 336.5 0.0 2.9e-100 335.7 0.0 1.3 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 KOS17417.1 - 5.6e-92 307.2 0.4 1e-91 306.3 0.4 1.4 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind PF16417.5 KOS17417.1 - 1.1e-43 148.6 0.0 1.6e-42 144.9 0.0 2.6 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT PF16418.5 KOS17417.1 - 1.8e-41 141.7 0.8 6.4e-41 139.9 0.1 2.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF3819 PF12842.7 KOS17417.1 - 4.9e-27 94.7 1.1 1e-26 93.6 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) Methyltransf_23 PF13489.6 KOS17418.1 - 2.2e-16 60.2 0.0 3.8e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS17418.1 - 1.9e-06 28.5 0.0 0.28 11.9 0.0 3.6 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOS17418.1 - 1.7e-05 25.4 0.1 0.0041 17.7 0.0 3.1 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17418.1 - 0.00014 22.6 0.0 0.086 13.6 0.0 2.8 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 KOS17418.1 - 0.0027 17.5 0.0 0.12 12.1 0.0 2.7 3 0 0 3 3 3 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS17418.1 - 0.17 11.2 0.0 2.4 7.4 0.0 2.1 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family Seipin PF06775.14 KOS17419.1 - 1.1e-56 192.0 0.6 1.5e-56 191.6 0.6 1.2 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Nop14 PF04147.12 KOS17419.1 - 5.2 5.1 14.0 6.8 4.8 14.0 1.1 1 0 0 1 1 1 0 Nop14-like family FCH PF00611.23 KOS17420.1 - 1.5e-16 60.4 0.7 3.8e-16 59.1 0.1 2.0 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DUF3570 PF12094.8 KOS17420.1 - 0.0075 15.1 0.1 0.012 14.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3570) DUF922 PF06037.11 KOS17420.1 - 0.016 15.0 5.1 0.018 14.9 0.7 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF922) DUF1759 PF03564.15 KOS17420.1 - 0.05 13.5 4.6 0.38 10.7 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1759) DUF4349 PF14257.6 KOS17420.1 - 0.45 9.9 5.4 3.1 7.2 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) DUF4407 PF14362.6 KOS17420.1 - 7.3 5.9 13.1 6.6 6.0 11.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) PADR1 PF08063.12 KOS17421.1 - 0.0068 16.2 1.2 0.0068 16.2 1.2 1.9 1 1 1 2 2 2 1 PADR1 (NUC008) domain TILa PF12714.7 KOS17421.1 - 0.41 10.6 7.2 3 7.9 3.8 2.2 1 1 1 2 2 2 0 TILa domain NTF2 PF02136.20 KOS17423.1 - 2.8e-09 37.6 0.0 3.6e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Hydrolase_like PF13242.6 KOS17424.1 - 0.00014 21.9 0.1 0.00027 20.9 0.1 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOS17424.1 - 0.017 15.4 0.0 0.21 11.9 0.0 2.2 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase VHS PF00790.19 KOS17425.1 - 2.3e-30 105.3 0.0 2.8e-15 56.4 0.0 2.6 2 0 0 2 2 2 2 VHS domain SH3_1 PF00018.28 KOS17425.1 - 1.8e-15 56.3 0.0 3.4e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS17425.1 - 3.7e-15 55.5 0.1 7.2e-15 54.6 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOS17425.1 - 9.3e-15 54.1 0.0 1.8e-14 53.1 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 KOS17425.1 - 1.7e-10 41.1 1.7 4e-10 39.9 1.7 1.7 1 0 0 1 1 1 1 GAT domain UIM PF02809.20 KOS17425.1 - 0.011 15.6 3.9 0.029 14.3 3.9 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif SNF2_N PF00176.23 KOS17426.1 - 2.3e-65 220.6 5.8 7.1e-63 212.4 5.8 3.1 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS17426.1 - 1.2e-17 64.3 0.2 1.3e-15 57.7 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17426.1 - 4.5e-05 23.5 0.0 0.00011 22.3 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOS17426.1 - 0.00018 21.3 0.0 0.00046 20.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase SMC_N PF02463.19 KOS17427.1 - 2.7e-60 203.5 0.0 9e-60 201.8 0.0 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOS17427.1 - 2.6e-25 89.0 0.0 1.2e-24 86.9 0.0 2.3 2 0 0 2 2 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOS17427.1 - 4.2e-13 49.8 0.6 3.2e-06 27.2 0.2 3.0 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOS17427.1 - 1.2e-07 31.4 0.0 2.7e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 KOS17427.1 - 8.2e-07 29.1 17.8 8.2e-07 29.1 17.8 4.5 2 2 1 3 3 1 1 AAA ATPase domain AAA_23 PF13476.6 KOS17427.1 - 2.3e-05 25.0 36.2 2.3e-05 25.0 36.2 6.5 3 2 2 5 5 2 1 AAA domain CALCOCO1 PF07888.11 KOS17427.1 - 0.0027 16.6 33.5 0.0027 16.6 33.5 5.1 3 2 2 5 5 3 2 Calcium binding and coiled-coil domain (CALCOCO1) like SbcCD_C PF13558.6 KOS17427.1 - 0.018 15.2 0.0 0.083 13.1 0.0 2.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF1664 PF07889.12 KOS17427.1 - 0.15 12.1 64.0 0.6 10.2 3.0 7.9 5 3 2 7 7 7 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 KOS17427.1 - 0.96 10.0 41.6 0.79 10.2 4.9 8.9 7 2 1 8 8 8 0 Nucleopolyhedrovirus P10 protein Filament PF00038.21 KOS17427.1 - 1.2 8.6 103.9 0.11 12.1 16.5 7.3 4 1 1 6 6 6 0 Intermediate filament protein FPP PF05911.11 KOS17427.1 - 2.6 6.1 91.7 0.56 8.3 8.1 4.1 3 1 1 4 4 4 0 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 KOS17427.1 - 7.5 5.3 116.5 0.036 13.0 13.1 7.4 3 2 5 8 8 8 0 Spc7 kinetochore protein V-SNARE_C PF12352.8 KOS17427.1 - 9.2 6.6 13.0 13 6.1 1.4 5.5 6 0 0 6 6 5 0 Snare region anchored in the vesicle membrane C-terminus Forkhead PF00250.18 KOS17428.1 - 1.1e-17 64.0 0.2 2.3e-17 63.0 0.2 1.5 1 0 0 1 1 1 1 Forkhead domain FAD_binding_7 PF03441.14 KOS17429.1 - 3.2e-81 271.7 0.1 6.2e-81 270.7 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOS17429.1 - 1.2e-38 132.6 0.0 1.9e-38 132.0 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase Cofilin_ADF PF00241.20 KOS17430.1 - 1.4e-17 63.6 0.0 1.7e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Nipped-B_C PF12830.7 KOS17431.1 - 3.8e-48 163.9 6.9 9.8e-48 162.6 0.1 3.4 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 KOS17431.1 - 2.3e-08 34.2 2.1 6.3e-08 32.8 1.0 2.5 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 KOS17431.1 - 4.5e-05 23.5 0.1 0.0041 17.2 0.0 2.8 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOS17431.1 - 0.00021 21.3 2.9 0.079 13.3 0.0 4.5 4 0 0 4 4 4 1 HEAT repeat Adaptin_N PF01602.20 KOS17431.1 - 0.0082 14.8 0.5 0.061 11.9 0.0 2.4 2 1 1 3 3 3 1 Adaptin N terminal region TFIIS_C PF01096.18 KOS17432.1 - 3.7e-13 49.1 1.1 3.7e-13 49.1 1.1 3.0 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOS17432.1 - 0.0012 18.7 2.3 0.0012 18.7 2.3 3.1 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit UCH_1 PF13423.6 KOS17432.1 - 0.0027 17.3 0.9 0.0031 17.2 0.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-RING_7 PF02591.15 KOS17432.1 - 0.0035 17.5 4.6 7.7 6.8 0.3 3.5 3 0 0 3 3 3 2 C4-type zinc ribbon domain Lar_restr_allev PF14354.6 KOS17432.1 - 0.029 14.7 9.1 0.1 13.0 0.2 3.1 2 1 0 2 2 2 0 Restriction alleviation protein Lar C1_1 PF00130.22 KOS17432.1 - 0.038 13.9 0.8 0.038 13.9 0.8 2.1 2 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.19 KOS17432.1 - 0.062 13.3 5.5 1.9 8.5 0.1 2.4 3 0 0 3 3 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TF_Zn_Ribbon PF08271.12 KOS17432.1 - 0.13 11.8 7.1 2.9 7.5 0.1 3.3 3 0 0 3 3 3 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 KOS17432.1 - 0.15 11.8 18.7 2.9 7.7 1.5 3.8 4 0 0 4 4 4 0 zinc-ribbon domain DUF3268 PF11672.8 KOS17432.1 - 0.27 11.5 0.1 0.27 11.5 0.1 2.1 2 1 0 2 2 2 0 zinc-finger-containing domain CpXC PF14353.6 KOS17432.1 - 0.32 11.1 6.4 0.37 10.8 0.2 2.5 1 1 1 2 2 2 0 CpXC protein XAF1_C PF18608.1 KOS17432.1 - 0.35 10.4 3.3 1.1 8.8 0.6 2.5 2 0 0 2 2 2 0 XIAP-associated factor 1 C-terminal domain NOB1_Zn_bind PF08772.11 KOS17432.1 - 0.43 10.8 7.1 1.8 8.8 0.3 3.1 2 1 0 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like zf-ISL3 PF14690.6 KOS17432.1 - 0.97 10.2 5.9 7 7.4 0.1 2.9 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DZR PF12773.7 KOS17432.1 - 1 9.4 11.8 4.9 7.3 8.4 2.6 1 1 0 1 1 1 0 Double zinc ribbon zf-IS66 PF13005.7 KOS17432.1 - 1.2 9.6 9.8 15 6.1 0.6 3.7 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 Ribosomal_S27e PF01667.17 KOS17432.1 - 2.2 8.1 8.7 12 5.7 0.4 2.9 2 2 0 2 2 2 0 Ribosomal protein S27 zf-ribbon_3 PF13248.6 KOS17432.1 - 2.5 7.7 9.8 1.9 8.0 0.3 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf_UBZ PF18439.1 KOS17432.1 - 3.6 7.3 6.5 12 5.5 0.0 3.1 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Zn_ribbon_recom PF13408.6 KOS17432.1 - 7.4 7.2 10.7 45 4.6 0.1 3.3 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain zf-LITAF-like PF10601.9 KOS17432.1 - 9.4 6.6 9.6 0.63 10.4 0.2 2.7 2 1 0 3 3 3 0 LITAF-like zinc ribbon domain Na_Ca_ex PF01699.24 KOS17433.1 - 6.1e-47 159.4 34.7 1.1e-24 87.1 14.1 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein DUF2631 PF10939.8 KOS17433.1 - 0.16 11.8 0.7 0.64 9.9 0.7 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2631) DUF2489 PF10675.9 KOS17433.1 - 0.72 9.8 4.6 4.2 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) Rox3 PF08633.10 KOS17433.1 - 3.9 7.7 6.6 0.52 10.6 0.9 2.0 2 0 0 2 2 2 0 Rox3 mediator complex subunit IML1 PF12257.8 KOS17434.1 - 2.1e-116 388.0 0.0 2.7e-116 387.7 0.0 1.1 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 FNIP_N PF14636.6 KOS17435.1 - 1.1e-36 127.1 0.0 1.1e-36 127.1 0.0 3.4 2 1 0 2 2 2 1 Folliculin-interacting protein N-terminus Abhydrolase_1 PF00561.20 KOS17436.1 - 6.8e-18 65.2 0.0 7.5e-14 52.0 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS17436.1 - 7.3e-13 49.6 1.1 9.8e-13 49.2 1.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS17436.1 - 9.5e-10 38.1 0.0 3.5e-09 36.3 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 BAAT_C PF08840.11 KOS17436.1 - 0.025 14.5 0.0 4.8 7.0 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 KOS17436.1 - 0.07 13.0 0.0 5.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase Ndr PF03096.14 KOS17436.1 - 0.13 10.9 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 Ndr family TerY_C PF15616.6 KOS17437.1 - 0.77 9.9 4.9 0.82 9.8 0.6 2.1 1 1 1 2 2 2 0 TerY-C metal binding domain pPIWI_RE_Z PF18155.1 KOS17438.1 - 0.034 14.0 1.5 0.12 12.3 0.0 2.5 3 0 0 3 3 3 0 pPIWI RE three-gene island domain Z Glyco_hydro_47 PF01532.20 KOS17439.1 - 2.7e-170 567.2 0.0 3.3e-170 566.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Fig1 PF12351.8 KOS17440.1 - 1.1e-57 195.0 4.3 1.1e-57 195.0 4.3 2.1 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 KOS17440.1 - 1.1e-07 31.7 9.0 1.8e-07 31.0 9.0 1.3 1 1 0 1 1 1 1 SUR7/PalI family DUF898 PF05987.13 KOS17440.1 - 0.01 14.9 11.4 0.03 13.4 11.5 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF898) DUF751 PF05421.11 KOS17440.1 - 0.17 12.6 0.1 0.17 12.6 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF751) FtsX PF02687.21 KOS17440.1 - 7 7.2 27.1 9.6 6.8 0.4 3.4 3 1 0 3 3 3 0 FtsX-like permease family Cupin_2 PF07883.11 KOS17441.1 - 2.1e-06 27.3 0.0 4e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Cupin domain RINT1_TIP1 PF04437.13 KOS17442.1 - 4.4e-167 557.0 0.0 6.2e-167 556.4 0.0 1.2 1 0 0 1 1 1 1 RINT-1 / TIP-1 family DUF4164 PF13747.6 KOS17442.1 - 0.12 12.7 10.4 6.5 7.1 5.0 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) CRISPR_Cse2 PF09485.10 KOS17442.1 - 3.8 8.0 10.2 0.64 10.5 4.7 2.7 3 1 0 3 3 3 0 CRISPR-associated protein Cse2 (CRISPR_cse2) Mito_carr PF00153.27 KOS17443.1 - 6.2e-55 183.1 3.5 1.2e-18 66.8 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein IMUP PF15761.5 KOS17443.1 - 3.2 8.5 5.7 1.4 9.6 3.3 1.6 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 KOS17443.1 - 3.6 7.1 6.2 5.5 6.5 6.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sec34 PF04136.15 KOS17444.1 - 3.3e-48 163.3 0.7 7.3e-48 162.2 0.7 1.6 1 0 0 1 1 1 1 Sec34-like family CDC37_M PF08565.11 KOS17444.1 - 0.0086 16.0 0.7 0.025 14.5 0.7 1.8 1 0 0 1 1 1 1 Cdc37 Hsp90 binding domain RseA_N PF03872.13 KOS17444.1 - 0.12 12.9 0.1 0.52 10.8 0.1 2.1 1 0 0 1 1 1 0 Anti sigma-E protein RseA, N-terminal domain RCC1 PF00415.18 KOS17445.1 - 2.7e-24 85.5 7.1 8.9e-06 26.2 0.1 7.3 6 1 1 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOS17445.1 - 3e-10 39.6 0.8 6.7e-08 32.1 0.0 6.8 8 1 0 8 8 8 3 Regulator of chromosome condensation (RCC1) repeat Y_phosphatase PF00102.27 KOS17446.1 - 2.5e-45 154.9 0.0 4.9e-45 153.9 0.0 1.4 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 KOS17446.1 - 6.5e-06 26.3 0.1 2.9e-05 24.2 0.0 2.2 3 0 0 3 3 3 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 KOS17446.1 - 0.0067 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KOS17446.1 - 0.034 14.0 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain HTH_38 PF13936.6 KOS17446.1 - 0.096 12.5 0.2 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain DeoC PF01791.9 KOS17447.1 - 0.00014 21.6 0.0 0.00018 21.2 0.0 1.1 1 0 0 1 1 1 1 DeoC/LacD family aldolase FMN_dh PF01070.18 KOS17447.1 - 0.015 14.4 0.2 0.015 14.4 0.2 1.6 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Glu_synthase PF01645.17 KOS17447.1 - 0.015 14.4 0.1 0.026 13.7 0.1 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase DHO_dh PF01180.21 KOS17447.1 - 0.11 11.6 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase AFG1_ATPase PF03969.16 KOS17448.1 - 3.1e-81 273.1 0.3 1e-76 258.2 0.0 2.1 2 0 0 2 2 2 2 AFG1-like ATPase POC1 PF10450.9 KOS17448.1 - 0.088 11.8 0.2 0.21 10.5 0.2 1.5 1 1 0 1 1 1 0 POC1 chaperone Amelotin PF15757.5 KOS17448.1 - 0.21 11.2 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Amelotin SH3_9 PF14604.6 KOS17449.1 - 3.2e-06 26.9 0.1 5.3e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 KOS17449.1 - 0.0052 16.4 0.0 0.0081 15.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOS17449.1 - 0.18 11.5 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 Variant SH3 domain Mito_carr PF00153.27 KOS17450.1 - 5.3e-56 186.6 3.0 3.3e-18 65.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Cation_efflux PF01545.21 KOS17451.1 - 1.6e-42 145.5 4.7 2e-42 145.2 4.7 1.1 1 0 0 1 1 1 1 Cation efflux family CDC45 PF02724.14 KOS17451.1 - 0.93 7.7 3.7 1.3 7.2 3.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Glyco_trans_1_4 PF13692.6 KOS17452.1 - 5.4e-07 30.1 0.0 1.5e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 KOS17452.1 - 4.7e-05 23.0 0.0 7.8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 KOS17452.1 - 0.0039 17.5 0.0 0.0086 16.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 DUF3142 PF11340.8 KOS17452.1 - 0.033 14.0 0.0 0.063 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3142) UQ_con PF00179.26 KOS17453.1 - 7.1e-36 122.9 0.0 8.5e-36 122.7 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOS17453.1 - 0.043 14.1 0.1 0.11 12.8 0.1 1.4 1 1 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 KOS17453.1 - 0.18 11.5 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B Herpes_pp85 PF04637.12 KOS17454.1 - 0.52 8.7 4.1 0.75 8.1 4.1 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SR-25 PF10500.9 KOS17454.1 - 2.4 7.7 8.6 4.1 7.0 8.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIIC_delta PF12657.7 KOS17455.1 - 7.7e-27 94.4 0.1 1.6e-26 93.4 0.1 1.5 1 0 0 1 1 1 1 Transcription factor IIIC subunit delta N-term zf-TFIIIC PF12660.7 KOS17455.1 - 1.1e-05 25.3 1.7 1.2e-05 25.2 0.2 1.8 2 0 0 2 2 2 1 Putative zinc-finger of transcription factor IIIC complex zf-NADH-PPase PF09297.11 KOS17455.1 - 6.6 6.5 9.0 9.8 5.9 0.5 3.6 3 0 0 3 3 3 0 NADH pyrophosphatase zinc ribbon domain Peptidase_C13 PF01650.18 KOS17456.1 - 3.1e-40 138.3 0.1 4.1e-40 137.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase C13 family His_Phos_1 PF00300.22 KOS17457.1 - 0.00099 18.8 0.0 0.28 10.9 0.1 3.2 2 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) CENP-B_dimeris PF09026.10 KOS17457.1 - 0.11 13.0 18.9 0.14 12.6 8.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 KOS17457.1 - 0.97 9.4 6.5 3.3 7.7 2.1 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal Ribosomal_60s PF00428.19 KOS17457.1 - 4.3 8.0 9.7 11 6.6 9.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein NOA36 PF06524.12 KOS17457.1 - 8 5.7 14.2 2.6 7.3 6.1 2.1 2 0 0 2 2 2 0 NOA36 protein Cnn_1N PF07989.11 KOS17458.1 - 1.7e-20 73.0 6.4 1.7e-20 73.0 6.4 11.9 6 3 7 13 13 13 3 Centrosomin N-terminal motif 1 Mto2_bdg PF12808.7 KOS17458.1 - 2e-09 37.6 11.3 2e-09 37.6 11.3 12.8 13 2 2 15 15 15 1 Micro-tubular organiser Mto1 C-term Mto2-binding region HIP1_clath_bdg PF16515.5 KOS17458.1 - 0.0056 17.3 10.5 0.0056 17.3 10.5 10.8 7 3 4 11 11 11 2 Clathrin-binding domain of Huntingtin-interacting protein 1 Imm7 PF15585.6 KOS17458.1 - 0.7 10.2 5.6 1 9.6 1.8 3.4 2 1 0 2 2 2 0 Immunity protein 7 PMSR PF01625.21 KOS17459.1 - 2.2e-59 200.0 0.1 2.6e-59 199.8 0.1 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase Pkinase PF00069.25 KOS17460.1 - 1.6e-70 237.5 0.0 2e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17460.1 - 5.3e-32 111.1 0.0 7.2e-32 110.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KOS17460.1 - 4.7e-10 40.0 3.1 1.3e-09 38.6 3.1 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOS17460.1 - 1.1e-05 24.6 0.0 1.6e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain C2 PF00168.30 KOS17460.1 - 0.00051 20.3 0.0 0.0019 18.5 0.0 2.0 1 1 0 1 1 1 1 C2 domain Kinase-like PF14531.6 KOS17460.1 - 0.024 14.0 0.0 0.055 12.8 0.0 1.6 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 KOS17460.1 - 0.19 11.3 0.1 1.8 8.1 0.0 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Glyco_hydro_76 PF03663.14 KOS17461.1 - 2.5e-25 89.8 0.6 7e-25 88.3 0.6 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 76 PALP PF00291.25 KOS17462.1 - 1.9e-74 250.8 0.1 2.5e-74 250.3 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 KOS17462.1 - 8.8e-36 121.6 0.0 7.5e-17 60.9 0.0 2.3 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase MMM1 PF10296.9 KOS17463.1 - 2.6e-07 30.0 0.0 5.9e-07 28.8 0.0 1.5 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 Spt5_N PF11942.8 KOS17463.1 - 3.6 8.6 23.7 4.7 8.3 3.3 3.3 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Aminotran_1_2 PF00155.21 KOS17464.1 - 3.6e-82 276.4 0.0 5e-82 276.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 KOS17464.1 - 7.3e-05 21.5 0.0 0.00012 20.7 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOS17464.1 - 0.0013 17.8 0.0 0.0021 17.1 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS17464.1 - 0.0024 17.3 0.9 0.004 16.5 0.2 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Preseq_ALAS PF09029.10 KOS17464.1 - 3.6 8.1 5.5 50 4.4 5.5 2.5 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence SNF2_N PF00176.23 KOS17465.1 - 1.4e-23 83.2 0.0 2.2e-23 82.6 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS17465.1 - 1.2e-22 80.4 0.1 3.5e-22 78.9 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KOS17465.1 - 0.0012 18.1 0.1 0.002 17.4 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 KOS17465.1 - 0.033 13.8 0.0 0.066 12.9 0.0 1.5 1 0 0 1 1 1 0 SWI2/SNF2 ATPase ResIII PF04851.15 KOS17465.1 - 0.045 13.7 0.1 0.62 10.0 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit MFS_1 PF07690.16 KOS17466.1 - 2.5e-30 105.6 28.0 2.5e-30 105.6 28.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KOS17466.1 - 0.00025 20.4 7.1 0.00025 20.4 7.1 2.2 2 0 0 2 2 2 2 Uncharacterised MFS-type transporter YbfB DUF2569 PF10754.9 KOS17466.1 - 0.015 15.7 4.2 0.03 14.8 3.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) Saf_2TM PF18303.1 KOS17466.1 - 0.077 12.6 2.5 0.12 12.0 0.4 2.2 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF2614 PF11023.8 KOS17466.1 - 1.2 9.3 5.4 0.79 9.8 1.5 2.5 2 0 0 2 2 2 0 Zinc-ribbon containing domain Nop PF01798.18 KOS17467.1 - 7.2e-75 251.4 0.4 7.2e-75 251.4 0.4 1.7 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KOS17467.1 - 5e-19 68.5 0.4 5e-19 68.5 0.4 2.4 2 0 0 2 2 2 1 NOP5NT (NUC127) domain CDC45 PF02724.14 KOS17467.1 - 1.4 7.1 17.7 1.9 6.7 17.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Roughex PF06020.11 KOS17467.1 - 1.6 7.8 10.6 2.9 6.9 10.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein RR_TM4-6 PF06459.12 KOS17467.1 - 7.1 6.4 16.0 12 5.6 16.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Cytomega_UL84 PF06284.11 KOS17467.1 - 8 4.8 9.8 15 3.9 9.8 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF913 PF06025.12 KOS17467.1 - 8.7 5.2 7.5 14 4.5 7.5 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 KOS17467.1 - 9 6.0 7.6 15 5.3 7.6 1.2 1 0 0 1 1 1 0 Connexin ELYS PF13934.6 KOS17469.1 - 3e-63 213.7 0.9 3.6e-63 213.5 0.9 1.0 1 0 0 1 1 1 1 Nuclear pore complex assembly TyrRSs_C PF16714.5 KOS17469.1 - 0.0057 16.5 0.0 0.0098 15.7 0.0 1.3 1 0 0 1 1 1 1 Tyrosyl-tRNA synthetase C-terminal domain EBP PF05241.12 KOS17470.1 - 1.7e-57 193.7 12.2 2e-57 193.5 12.2 1.0 1 0 0 1 1 1 1 Emopamil binding protein UNC-93 PF05978.16 KOS17471.1 - 9.3e-10 38.4 6.1 9.3e-10 38.4 6.1 2.3 2 1 0 2 2 2 1 Ion channel regulatory protein UNC-93 MFS_1 PF07690.16 KOS17471.1 - 3.2e-09 36.2 41.5 2.9e-08 33.0 42.6 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily MotA_ExbB PF01618.16 KOS17471.1 - 2.2 8.1 5.1 0.78 9.5 1.0 2.3 2 0 0 2 2 2 0 MotA/TolQ/ExbB proton channel family Hist_deacetyl PF00850.19 KOS17472.1 - 7.2e-83 278.6 0.0 7.2e-83 278.6 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylase domain MFS_1 PF07690.16 KOS17473.1 - 3.1e-30 105.3 26.1 9.8e-25 87.2 16.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS17473.1 - 8.2e-09 34.8 5.2 8.2e-09 34.8 5.2 2.0 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KOS17473.1 - 0.011 14.2 0.3 0.017 13.6 0.3 1.2 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) MFS_1_like PF12832.7 KOS17473.1 - 0.32 9.8 14.3 0.015 14.2 4.1 3.0 3 1 0 3 3 3 0 MFS_1 like family zf-H2C2 PF09337.10 KOS17474.1 - 9.4e-15 54.5 3.4 2.4e-14 53.3 3.4 1.7 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 KOS17474.1 - 2.8e-11 43.3 0.3 1.2e-10 41.4 0.3 2.1 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 KOS17474.1 - 2.2e-05 24.7 0.0 4e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_4 PF13420.7 KOS17474.1 - 0.014 15.6 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS17474.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Ribosomal_S2 PF00318.20 KOS17475.1 - 4.1e-64 215.7 0.1 6.4e-63 211.9 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein S2 DUF2407_C PF13373.6 KOS17475.1 - 0.023 14.9 2.7 0.051 13.8 2.7 1.5 1 0 0 1 1 1 0 DUF2407 C-terminal domain AJAP1_PANP_C PF15298.6 KOS17475.1 - 0.13 12.5 12.4 0.25 11.5 12.4 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus LPP20 PF02169.16 KOS17475.1 - 1.1 9.7 6.1 2.2 8.7 5.1 2.0 2 0 0 2 2 2 0 LPP20 lipoprotein FSA_C PF10479.9 KOS17475.1 - 2.7 6.0 10.4 3.9 5.5 10.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 KOS17475.1 - 6.2 6.8 29.5 0.73 9.8 24.1 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein Dicty_REP PF05086.12 KOS17475.1 - 7.9 4.3 6.3 11 3.9 6.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein XFP_N PF09364.10 KOS17476.1 - 8.7e-170 564.4 0.0 1.2e-169 564.0 0.0 1.1 1 0 0 1 1 1 1 XFP N-terminal domain XFP PF03894.15 KOS17476.1 - 1.5e-83 278.8 0.0 2.5e-83 278.1 0.0 1.3 1 0 0 1 1 1 1 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase XFP_C PF09363.10 KOS17476.1 - 1.3e-76 256.5 0.0 2.2e-76 255.9 0.0 1.3 1 0 0 1 1 1 1 XFP C-terminal domain Tma16 PF11176.8 KOS17476.1 - 0.019 14.8 0.2 0.045 13.6 0.0 1.6 2 0 0 2 2 2 0 Translation machinery-associated protein 16 Cpn60_TCP1 PF00118.24 KOS17477.1 - 9.4e-156 519.3 5.6 1.1e-155 519.1 5.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PNTB_4TM PF12769.7 KOS17477.1 - 0.19 12.2 0.1 0.74 10.3 0.0 2.0 2 0 0 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-oxoacid_dh PF00198.23 KOS17478.1 - 5.9e-80 268.1 0.0 9.8e-80 267.3 0.0 1.4 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOS17478.1 - 1.2e-15 57.0 2.6 2.7e-15 56.0 2.6 1.6 1 0 0 1 1 1 1 Biotin-requiring enzyme DUF3614 PF12267.8 KOS17478.1 - 0.02 15.4 2.3 0.23 11.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3614) Biotin_lipoyl_2 PF13533.6 KOS17478.1 - 0.1 12.4 1.7 3.5 7.5 0.2 2.4 1 1 1 2 2 2 0 Biotin-lipoyl like Presenilin PF01080.17 KOS17478.1 - 1.4 7.6 4.7 1.9 7.2 4.7 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 KOS17478.1 - 1.9 7.1 5.3 2.5 6.7 5.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-MYND PF01753.18 KOS17479.1 - 6.8e-12 45.3 15.9 1.3e-11 44.4 15.9 1.5 1 0 0 1 1 1 1 MYND finger DUF4470 PF14737.6 KOS17479.1 - 5.7e-11 42.5 0.3 2.3e-06 27.7 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4470) zf-C6H2 PF15801.5 KOS17479.1 - 2.3 8.6 11.9 5.3 7.4 11.9 1.6 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding CBS PF00571.28 KOS17480.1 - 9e-33 112.5 13.7 1e-08 35.5 0.0 6.6 6 1 1 7 7 7 4 CBS domain PB1 PF00564.24 KOS17480.1 - 4.2e-08 33.0 0.0 9.3e-08 31.9 0.0 1.6 1 0 0 1 1 1 1 PB1 domain SLAIN PF15301.6 KOS17480.1 - 0.26 10.5 2.0 0.68 9.1 2.0 1.6 1 0 0 1 1 1 0 SLAIN motif-containing family FCP1_C PF09309.10 KOS17480.1 - 0.4 10.5 9.5 0.78 9.6 2.1 2.2 2 0 0 2 2 2 0 FCP1, C-terminal CENP-B_dimeris PF09026.10 KOS17480.1 - 0.43 11.0 8.7 11 6.5 4.1 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Myc_N PF01056.18 KOS17480.1 - 1.6 8.5 8.1 1.6 8.5 2.6 2.3 2 0 0 2 2 2 0 Myc amino-terminal region Prothymosin PF03247.14 KOS17480.1 - 3.2 8.3 19.5 5.7 7.4 6.3 2.4 2 0 0 2 2 2 0 Prothymosin/parathymosin family PBP1_TM PF14812.6 KOS17480.1 - 3.7 8.0 8.8 9.3 6.7 1.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2 PF00096.26 KOS17481.1 - 2e-09 37.4 10.1 2.9e-05 24.3 4.9 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS17481.1 - 2e-08 34.3 8.2 0.00096 19.5 1.4 2.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS17481.1 - 1.7e-05 25.2 9.5 0.01 16.6 4.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 KOS17481.1 - 0.035 13.9 1.5 0.063 13.0 1.5 1.5 1 0 0 1 1 1 0 zinc-finger C2H2-type C1_4 PF07975.12 KOS17481.1 - 0.039 14.2 4.1 0.082 13.2 4.1 1.5 1 0 0 1 1 1 0 TFIIH C1-like domain zf-BED PF02892.15 KOS17481.1 - 0.17 11.9 2.6 0.66 10.0 2.6 1.9 1 1 0 1 1 1 0 BED zinc finger zf-met PF12874.7 KOS17481.1 - 3.5 8.1 6.0 5.5 7.5 2.3 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOS17481.1 - 4 7.9 8.8 12 6.3 3.6 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Cpn60_TCP1 PF00118.24 KOS17482.1 - 2e-165 551.2 1.2 2.3e-165 551.0 1.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family PDCD2_C PF04194.13 KOS17483.1 - 1.4e-43 149.0 0.0 1.5e-42 145.6 0.0 2.4 3 0 0 3 3 3 1 Programmed cell death protein 2, C-terminal putative domain YqzE PF14038.6 KOS17483.1 - 0.2 11.7 0.6 0.36 10.9 0.6 1.4 1 0 0 1 1 1 0 YqzE-like protein GTP_EFTU PF00009.27 KOS17484.1 - 1.9e-67 226.6 0.5 2.9e-67 226.0 0.5 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOS17484.1 - 1.2e-32 112.3 0.0 3.1e-32 110.9 0.0 1.8 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 KOS17484.1 - 4.6e-21 74.7 0.0 1.3e-20 73.2 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOS17484.1 - 1.6e-13 50.8 0.0 4.6e-13 49.4 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOS17484.1 - 2.2e-12 46.9 0.0 6.1e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 KOS17484.1 - 0.00038 20.5 0.3 0.00093 19.3 0.3 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 KOS17484.1 - 0.13 12.0 0.2 0.46 10.2 0.1 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Solute_trans_a PF03619.16 KOS17487.1 - 9.7e-100 333.5 12.2 1.2e-99 333.2 12.2 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Glyco_hydro_92 PF07971.12 KOS17488.1 - 4.5e-121 405.0 0.0 5.7e-121 404.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOS17488.1 - 1.1e-33 117.2 2.6 2.3e-33 116.1 2.6 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain TRAF6_Z2 PF18048.1 KOS17489.1 - 0.07 13.2 0.6 0.19 11.9 0.6 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 PSD4 PF07631.11 KOS17489.1 - 0.1 13.1 0.6 0.38 11.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1592) Zn_clus PF00172.18 KOS17489.1 - 0.62 10.2 12.8 0.03 14.5 6.8 2.0 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-BED PF02892.15 KOS17489.1 - 8.2 6.5 8.6 0.16 12.0 0.9 2.2 3 0 0 3 3 3 0 BED zinc finger Sec5 PF15469.6 KOS17490.1 - 3.9e-37 127.9 0.1 2.9e-36 125.1 0.0 2.5 3 0 0 3 3 3 1 Exocyst complex component Sec5 Vps51 PF08700.11 KOS17490.1 - 8.9e-05 22.5 3.5 0.0017 18.4 0.2 3.5 3 0 0 3 3 3 1 Vps51/Vps67 CobT PF06213.12 KOS17490.1 - 2.3 7.6 7.1 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Ku_PK_bind PF08785.11 KOS17490.1 - 5.3 7.2 5.5 12 6.1 0.1 3.9 5 0 0 5 5 5 0 Ku C terminal domain like Iso_dh PF00180.20 KOS17491.1 - 4.5e-100 335.2 0.1 5.1e-100 335.0 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Phage_30_3 PF08010.11 KOS17491.1 - 0.055 13.3 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Bacteriophage protein GP30.3 HHH_2 PF12826.7 KOS17491.1 - 0.062 13.4 0.0 0.71 10.0 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif Transglut_core PF01841.19 KOS17493.1 - 6.2e-10 39.5 0.0 1.2e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Gln_amidase PF15644.6 KOS17493.1 - 0.01 16.8 0.0 0.023 15.7 0.0 1.7 1 1 0 1 1 1 0 Papain fold toxin 1, glutamine deamidase DUF553 PF04473.12 KOS17493.1 - 0.025 14.1 0.0 0.81 9.2 0.1 2.5 2 1 0 2 2 2 0 Transglutaminase-like domain Neuraminidase PF18413.1 KOS17494.1 - 0.0061 16.2 0.2 0.9 9.2 0.0 3.4 3 1 0 3 3 3 2 Neuraminidase-like domain MARVEL PF01284.23 KOS17495.1 - 0.00024 21.1 11.2 0.00083 19.4 10.3 1.9 1 1 1 2 2 2 1 Membrane-associating domain ABC2_membrane PF01061.24 KOS17495.1 - 0.18 11.2 6.7 0.12 11.8 4.6 1.6 2 0 0 2 2 2 0 ABC-2 type transporter TraL PF07178.11 KOS17495.1 - 0.22 12.0 0.1 0.22 12.0 0.1 2.4 2 1 1 3 3 3 0 TraL protein TPR_1 PF00515.28 KOS17497.1 - 1.9e-41 138.2 22.5 1.7e-07 30.7 0.2 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 KOS17497.1 - 6.9e-33 110.1 20.0 7.2e-05 22.6 0.1 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 KOS17497.1 - 1.5e-32 111.3 16.6 3.6e-16 58.8 3.3 2.7 2 0 0 2 2 2 2 STI1 domain TPR_11 PF13414.6 KOS17497.1 - 6.3e-18 64.2 15.1 0.0032 17.1 0.5 6.8 5 1 0 6 6 6 5 TPR repeat TPR_8 PF13181.6 KOS17497.1 - 5.9e-15 54.2 28.5 2.4e-06 27.3 0.6 8.4 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOS17497.1 - 1.4e-13 50.9 11.8 1.6e-09 37.9 0.2 5.7 5 3 1 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS17497.1 - 9.6e-10 38.9 4.9 0.027 15.1 0.0 5.8 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOS17497.1 - 1.2e-09 37.5 3.9 0.0024 17.8 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOS17497.1 - 3.2e-09 36.8 8.4 0.34 11.8 0.0 8.0 6 2 3 9 9 8 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOS17497.1 - 9e-09 35.7 7.0 0.031 14.8 0.0 6.5 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS17497.1 - 1.3e-08 34.6 1.6 0.92 10.0 0.1 6.9 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS17497.1 - 1.9e-08 34.3 0.0 0.063 13.4 0.0 4.4 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 KOS17497.1 - 3.9e-06 26.6 5.3 0.4 10.6 0.0 6.0 8 0 0 8 8 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOS17497.1 - 0.0024 17.3 0.3 2.4 7.7 0.1 3.4 3 0 0 3 3 3 1 SHNi-TPR DUF3856 PF12968.7 KOS17497.1 - 0.0065 16.5 5.4 2.2 8.4 0.3 4.8 3 3 1 4 4 4 1 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.6 KOS17497.1 - 0.02 15.0 0.4 5.2 7.2 0.0 4.2 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.4 KOS17497.1 - 0.064 13.1 6.7 2.9 7.7 0.2 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) TPR_6 PF13174.6 KOS17497.1 - 0.16 12.6 0.1 0.16 12.6 0.1 6.9 8 0 0 8 8 6 0 Tetratricopeptide repeat MIT PF04212.18 KOS17497.1 - 0.19 11.8 18.0 4.6 7.4 0.1 6.5 7 1 0 7 7 5 0 MIT (microtubule interacting and transport) domain DUF5486 PF17588.2 KOS17497.1 - 0.35 10.8 3.0 6.1 6.8 1.4 2.9 2 0 0 2 2 2 0 Family of unknown function (DUF5486) DUF3391 PF11871.8 KOS17497.1 - 2 9.0 12.7 0.079 13.5 0.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) RFX_DNA_binding PF02257.15 KOS17498.1 - 1.5e-27 96.0 0.0 3.3e-27 94.9 0.0 1.6 1 0 0 1 1 1 1 RFX DNA-binding domain Cdc6_C PF09079.11 KOS17498.1 - 0.15 12.1 0.0 0.42 10.6 0.0 1.8 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Sporozoite_P67 PF05642.11 KOS17498.1 - 0.28 9.2 3.6 0.47 8.5 3.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 KOS17498.1 - 3.7 6.8 9.0 0.19 11.0 3.7 1.5 2 0 0 2 2 2 0 NOA36 protein DNA_pol_phi PF04931.13 KOS17498.1 - 7.9 4.4 5.1 13 3.7 5.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi AA_kinase PF00696.28 KOS17499.1 - 4.2e-34 118.2 0.0 1.8e-33 116.1 0.0 2.1 2 1 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 KOS17499.1 - 3.4e-14 52.3 2.0 6.1e-08 32.3 0.1 2.8 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 KOS17499.1 - 8.6e-14 51.1 3.2 9.5e-09 34.9 0.1 2.5 2 0 0 2 2 2 2 ACT domain Adaptin_N PF01602.20 KOS17500.1 - 2.7e-81 273.7 0.0 4.9e-81 272.9 0.0 1.4 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 KOS17500.1 - 0.0082 16.6 3.2 4.3 7.9 0.0 4.7 5 0 0 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 KOS17500.1 - 0.014 15.5 0.3 0.19 11.8 0.0 2.7 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 ECH_1 PF00378.20 KOS17501.1 - 1.2e-72 244.2 0.0 1.4e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS17501.1 - 1.6e-34 119.9 0.1 4.2e-32 112.0 0.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase DapB_N PF01113.20 KOS17502.1 - 0.002 18.2 0.0 0.0022 18.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 KOS17502.1 - 0.017 14.6 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOS17502.1 - 0.08 12.8 0.0 0.09 12.7 0.0 1.1 1 0 0 1 1 1 0 NAD(P)H-binding Bax1-I PF01027.20 KOS17503.1 - 5.3e-33 114.6 8.5 9.3e-33 113.8 8.5 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 SNF2_N PF00176.23 KOS17504.1 - 2.3e-72 243.6 1.4 2.3e-72 243.6 1.4 2.3 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS17504.1 - 1.6e-21 76.7 0.4 9.8e-19 67.7 0.0 3.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Bromodomain PF00439.25 KOS17504.1 - 3.1e-20 72.0 0.1 9.1e-20 70.5 0.1 1.8 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 KOS17504.1 - 3.4e-17 62.5 12.2 3.4e-17 62.5 12.2 4.1 5 0 0 5 5 5 1 HSA SnAC PF14619.6 KOS17504.1 - 1.7e-15 57.4 0.5 1.7e-15 57.4 0.5 4.1 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex QLQ PF08880.11 KOS17504.1 - 6.2e-12 45.1 3.4 2.4e-11 43.2 3.4 2.1 1 0 0 1 1 1 1 QLQ ResIII PF04851.15 KOS17504.1 - 3.7e-09 36.8 0.1 3.7e-09 36.8 0.1 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit RBR PF17208.3 KOS17504.1 - 0.00065 20.4 5.6 0.00065 20.4 5.6 3.4 3 1 1 4 4 4 1 RNA binding Region DEDD_Tnp_IS110 PF01548.17 KOS17504.1 - 3.3 7.6 9.3 1.7 8.5 5.6 2.4 2 0 0 2 2 2 0 Transposase DUF167 PF02594.16 KOS17505.1 - 1.9e-22 79.2 0.1 2.4e-22 78.8 0.1 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 CP2 PF04516.15 KOS17506.1 - 4.4e-50 170.1 0.0 4.9e-40 137.2 0.0 2.9 2 1 1 3 3 3 2 CP2 transcription factor Tektin PF03148.14 KOS17506.1 - 0.043 12.6 0.2 0.08 11.7 0.2 1.4 1 0 0 1 1 1 0 Tektin family SMBP PF16785.5 KOS17506.1 - 0.053 13.7 0.3 0.11 12.8 0.3 1.4 1 0 0 1 1 1 0 Small metal-binding protein Cep57_MT_bd PF06657.13 KOS17506.1 - 1.2 9.6 5.4 4.5 7.8 0.2 3.4 4 0 0 4 4 4 0 Centrosome microtubule-binding domain of Cep57 RRN9 PF10680.9 KOS17507.1 - 3.1 8.1 4.6 32 4.9 4.3 2.4 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor eIF2A PF08662.11 KOS17508.1 - 4.4e-78 261.6 0.0 1.8e-77 259.6 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 KOS17508.1 - 0.0006 20.6 0.1 5.5 8.0 0.1 5.0 3 2 1 4 4 4 1 WD domain, G-beta repeat GPP34 PF05719.11 KOS17509.1 - 2.1e-67 227.1 0.1 2.6e-67 226.8 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) DUF1453 PF07301.11 KOS17510.1 - 0.036 14.1 1.4 5.5 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) W2 PF02020.18 KOS17511.1 - 4.4e-20 71.6 1.5 9e-20 70.6 1.5 1.6 1 0 0 1 1 1 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 KOS17511.1 - 1.1e-09 37.6 11.5 1.6e-06 27.6 3.8 3.9 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 KOS17511.1 - 0.00013 21.7 0.0 0.00022 20.9 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 KOS17511.1 - 0.00052 18.3 1.3 0.001 17.3 0.8 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 KOS17511.1 - 0.00074 19.2 11.4 0.0035 17.0 2.8 3.8 2 1 2 4 4 4 2 Hexapeptide repeat of succinyl-transferase NTP_transf_3 PF12804.7 KOS17511.1 - 0.014 15.7 0.0 0.034 14.5 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain Fucokinase PF07959.12 KOS17511.1 - 0.1 11.6 0.1 0.21 10.5 0.1 1.5 1 1 0 1 1 1 0 L-fucokinase HAD_SAK_1 PF10307.9 KOS17512.1 - 8.1e-77 257.6 0.0 1.2e-76 257.1 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins RPAP1_C PF08620.10 KOS17513.1 - 1.9e-27 95.2 0.1 3.5e-27 94.3 0.1 1.5 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 KOS17513.1 - 7.6e-18 64.0 6.1 1.2e-17 63.4 6.1 1.3 1 0 0 1 1 1 1 RPAP1-like, N-terminal VHS PF00790.19 KOS17514.1 - 3.6e-45 153.3 0.0 1.5e-44 151.3 0.0 2.0 2 0 0 2 2 2 1 VHS domain GAT PF03127.14 KOS17514.1 - 2e-19 69.6 1.6 3.1e-19 69.1 0.1 2.1 2 0 0 2 2 2 1 GAT domain Alpha_adaptinC2 PF02883.20 KOS17514.1 - 1.4e-17 64.0 0.0 1.4e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 Adaptin C-terminal domain GGA_N-GAT PF18308.1 KOS17514.1 - 2.2e-08 33.6 0.0 6.1e-08 32.2 0.0 1.7 1 0 0 1 1 1 1 GGA N-GAT domain Roughex PF06020.11 KOS17514.1 - 0.095 11.8 3.6 0.22 10.6 3.6 1.5 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 KOS17514.1 - 0.34 10.5 7.2 0.59 9.7 7.2 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KOS17514.1 - 2.5 8.0 13.4 0.59 10.1 8.2 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Sec10 PF07393.11 KOS17515.1 - 6.1e-157 524.1 0.0 1.3e-156 523.0 0.0 1.5 1 1 0 1 1 1 1 Exocyst complex component Sec10 F-box-like PF12937.7 KOS17515.1 - 1.5e-06 28.0 0.4 4.7e-06 26.4 0.0 2.0 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KOS17515.1 - 2.8e-05 23.8 0.0 5.2e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 F-box domain Pex14_N PF04695.13 KOS17515.1 - 0.33 11.6 11.5 0.027 15.1 4.2 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 KOS17515.1 - 4.5 7.2 18.3 0.2 11.6 12.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Pyr_redox_2 PF07992.14 KOS17516.1 - 5.4e-50 170.3 0.0 8.8e-43 146.6 0.0 2.1 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS17516.1 - 8.3e-14 51.9 0.0 4.2e-11 43.3 0.0 3.0 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS17516.1 - 2.3e-07 30.4 0.0 0.00061 19.1 0.0 2.8 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS17516.1 - 0.002 17.7 6.4 1.2 8.6 0.0 3.7 2 1 1 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS17516.1 - 0.039 14.2 0.1 17 5.7 0.0 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 KOS17516.1 - 0.13 12.3 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase OB_NTP_bind PF07717.16 KOS17516.1 - 0.15 12.5 0.0 0.37 11.2 0.0 1.7 1 0 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold Frag1 PF10277.9 KOS17517.1 - 3.2e-40 138.0 17.6 3.7e-40 137.8 17.6 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Tetraspanin PF00335.20 KOS17517.1 - 0.2 11.3 6.7 0.016 14.9 1.9 1.7 2 0 0 2 2 2 0 Tetraspanin family DUF3754 PF12576.8 KOS17517.1 - 0.42 10.5 2.2 1.5 8.8 2.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3754) TPR_19 PF14559.6 KOS17518.1 - 1e-10 42.0 5.5 6.3e-06 26.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOS17518.1 - 1.1e-08 34.6 0.2 6.3e-05 22.6 0.0 3.8 3 1 1 4 4 4 2 TPR repeat TPR_2 PF07719.17 KOS17518.1 - 4.4e-08 32.6 0.5 0.00066 19.6 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS17518.1 - 1.3e-07 31.1 0.6 0.002 17.9 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS17518.1 - 2.4e-05 24.2 2.4 0.22 11.8 0.3 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS17518.1 - 2.5e-05 24.7 0.6 0.0017 19.0 0.0 5.1 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS17518.1 - 4e-05 24.2 5.0 4.6e-05 24.0 0.0 3.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOS17518.1 - 0.0035 17.9 4.8 5.1 8.0 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS17518.1 - 0.0048 17.0 0.2 0.013 15.6 0.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS17518.1 - 0.006 16.9 0.1 0.061 13.7 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS17518.1 - 0.007 16.6 5.7 4.5 7.6 0.7 4.6 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS17518.1 - 0.024 14.7 0.2 34 4.8 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_S6 PF01250.17 KOS17518.1 - 0.037 14.3 0.0 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein S6 Proteasome PF00227.26 KOS17520.1 - 2e-54 184.0 0.2 3e-54 183.4 0.2 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOS17520.1 - 1.1e-11 44.2 0.4 3.6e-11 42.5 0.1 2.0 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature PALP PF00291.25 KOS17521.1 - 7.6e-67 225.8 0.1 9e-67 225.5 0.1 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CCDC53 PF10152.9 KOS17522.1 - 0.00064 20.2 1.1 0.0012 19.3 1.1 1.4 1 1 0 1 1 1 1 Subunit CCDC53 of WASH complex Band_3_cyto PF07565.13 KOS17522.1 - 0.00082 19.3 6.5 0.029 14.2 4.9 2.1 2 0 0 2 2 2 1 Band 3 cytoplasmic domain FAM176 PF14851.6 KOS17522.1 - 0.0018 17.9 4.0 0.0036 17.0 4.0 1.5 1 0 0 1 1 1 1 FAM176 family eIF-3_zeta PF05091.12 KOS17522.1 - 0.0023 17.0 1.8 0.0028 16.7 1.8 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TFIIA PF03153.13 KOS17522.1 - 0.0025 17.9 9.0 0.0035 17.4 9.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Myc_N PF01056.18 KOS17522.1 - 0.0042 17.0 1.1 0.006 16.5 1.1 1.3 1 0 0 1 1 1 1 Myc amino-terminal region MDM31_MDM32 PF08118.11 KOS17522.1 - 0.0049 15.6 1.1 0.0078 14.9 1.1 1.3 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF2052 PF09747.9 KOS17522.1 - 0.0062 16.7 7.9 0.011 15.9 7.9 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) IlvN PF07991.12 KOS17522.1 - 0.0075 15.9 0.5 4.3 6.9 0.1 2.5 2 1 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FHIPEP PF00771.20 KOS17522.1 - 0.0093 14.5 1.0 0.013 14.0 1.0 1.1 1 0 0 1 1 1 1 FHIPEP family Spt20 PF12090.8 KOS17522.1 - 0.011 15.3 17.5 0.018 14.7 17.5 1.2 1 0 0 1 1 1 0 Spt20 family DDHD PF02862.17 KOS17522.1 - 0.013 15.7 1.1 0.018 15.2 1.1 1.3 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.10 KOS17522.1 - 0.014 14.1 8.8 0.018 13.8 8.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF5523 PF17661.1 KOS17522.1 - 0.019 14.7 9.2 0.032 13.9 9.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Presenilin PF01080.17 KOS17522.1 - 0.025 13.3 2.7 0.032 13.0 2.7 1.1 1 0 0 1 1 1 0 Presenilin PIEZO PF15917.5 KOS17522.1 - 0.027 14.0 9.0 0.041 13.3 9.0 1.2 1 0 0 1 1 1 0 Piezo DUF4834 PF16118.5 KOS17522.1 - 0.035 15.1 9.6 0.073 14.0 9.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) HNOBA PF07701.14 KOS17522.1 - 0.041 13.3 4.4 0.064 12.7 4.4 1.3 1 0 0 1 1 1 0 Heme NO binding associated DUF1682 PF07946.14 KOS17522.1 - 0.058 12.6 10.2 0.091 12.0 10.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CLN3 PF02487.17 KOS17522.1 - 0.071 12.1 0.8 0.092 11.8 0.8 1.1 1 0 0 1 1 1 0 CLN3 protein SpoIIP PF07454.11 KOS17522.1 - 0.072 12.5 6.9 0.11 11.9 6.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) MscS_TM PF12794.7 KOS17522.1 - 0.073 11.9 7.2 0.11 11.3 7.2 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 RPN2_C PF18004.1 KOS17522.1 - 0.076 12.9 10.4 0.13 12.2 10.4 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain UPF0560 PF10577.9 KOS17522.1 - 0.09 11.3 7.2 0.12 10.8 7.2 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Usp PF00582.26 KOS17522.1 - 0.092 13.3 2.2 0.19 12.2 2.2 1.5 1 0 0 1 1 1 0 Universal stress protein family Eapp_C PF10238.9 KOS17522.1 - 0.098 12.7 5.3 0.17 12.0 5.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein RNase_H2_suC PF08615.11 KOS17522.1 - 0.099 12.8 1.4 0.18 12.0 1.4 1.4 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) FYDLN_acid PF09538.10 KOS17522.1 - 0.1 13.3 5.0 0.2 12.3 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) AIF_C PF14721.6 KOS17522.1 - 0.1 12.9 3.9 0.24 11.8 3.9 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CobT PF06213.12 KOS17522.1 - 0.11 11.8 11.3 0.2 11.0 11.3 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF913 PF06025.12 KOS17522.1 - 0.12 11.4 1.6 0.17 10.8 1.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FliP PF00813.20 KOS17522.1 - 0.12 12.3 0.3 0.2 11.5 0.3 1.3 1 0 0 1 1 1 0 FliP family DUF4820 PF16091.5 KOS17522.1 - 0.21 10.9 7.8 0.36 10.1 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) O-antigen_lig PF13425.6 KOS17522.1 - 0.22 10.3 0.7 0.28 9.9 0.7 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Med3 PF11593.8 KOS17522.1 - 0.27 10.4 10.0 0.4 9.8 10.0 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Neur_chan_memb PF02932.16 KOS17522.1 - 0.28 11.2 1.8 0.41 10.7 1.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region WRNPLPNID PF15017.6 KOS17522.1 - 0.34 11.8 9.3 0.69 10.8 9.3 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Pinin_SDK_memA PF04696.13 KOS17522.1 - 0.38 10.8 20.2 0.3 11.1 17.7 2.0 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region SID-1_RNA_chan PF13965.6 KOS17522.1 - 0.5 8.7 1.0 0.62 8.4 1.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TERB2 PF15101.6 KOS17522.1 - 0.54 10.3 8.9 0.81 9.7 8.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MMR1 PF08505.10 KOS17522.1 - 0.57 10.4 8.1 0.86 9.8 8.1 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF5568 PF17724.1 KOS17522.1 - 0.57 10.0 3.8 1 9.1 3.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5568) Connexin PF00029.19 KOS17522.1 - 0.59 9.8 5.6 0.9 9.2 5.6 1.2 1 0 0 1 1 1 0 Connexin Rsc14 PF08586.10 KOS17522.1 - 0.63 10.9 4.2 1.6 9.6 4.2 1.7 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Serinc PF03348.15 KOS17522.1 - 0.72 8.7 2.5 0.98 8.3 2.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MDM10 PF12519.8 KOS17522.1 - 0.82 8.5 3.5 1.2 8.0 3.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Folate_carrier PF01770.18 KOS17522.1 - 0.85 8.3 2.6 1.1 7.9 2.6 1.1 1 0 0 1 1 1 0 Reduced folate carrier BSP_II PF05432.11 KOS17522.1 - 0.86 9.2 10.5 1.3 8.7 10.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Sporozoite_P67 PF05642.11 KOS17522.1 - 0.88 7.6 4.1 1.3 7.0 4.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2722 PF10846.8 KOS17522.1 - 0.94 8.3 16.5 1.4 7.8 16.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TMEM51 PF15345.6 KOS17522.1 - 0.98 9.2 8.8 1.6 8.5 8.8 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Ureide_permease PF07168.11 KOS17522.1 - 1.1 8.0 2.3 1.5 7.5 2.3 1.2 1 0 0 1 1 1 0 Ureide permease ATP-synt_E PF05680.12 KOS17522.1 - 1.1 9.7 9.6 2.7 8.4 9.6 1.6 1 0 0 1 1 1 0 ATP synthase E chain OATP PF03137.20 KOS17522.1 - 1.1 7.4 2.4 1.6 6.9 2.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 KOS17522.1 - 1.3 6.8 7.7 1.9 6.3 7.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TFB6 PF17110.5 KOS17522.1 - 1.5 8.6 6.3 2.6 7.8 6.3 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Porph_ging PF09697.10 KOS17522.1 - 3 8.5 6.7 6.2 7.4 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) Sec62 PF03839.16 KOS17522.1 - 4.2 6.8 6.5 6.5 6.2 6.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Ribosomal_60s PF00428.19 KOS17522.1 - 4.4 8.0 9.0 24 5.6 7.5 2.7 3 0 0 3 3 2 0 60s Acidic ribosomal protein Conotoxin PF02950.17 KOS17522.1 - 4.5 8.4 4.8 10 7.2 4.8 1.5 1 0 0 1 1 1 0 Conotoxin Tim54 PF11711.8 KOS17522.1 - 4.8 5.8 11.7 7.5 5.2 11.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 EIIBC-GUT_N PF03612.14 KOS17522.1 - 5.3 6.7 8.5 11 5.7 8.5 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Bd3614-deam PF14439.6 KOS17524.1 - 0.063 13.4 4.7 0.093 12.8 4.7 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase CH PF00307.31 KOS17525.1 - 1.1e-46 157.5 0.2 6.2e-22 77.8 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain EFhand_Ca_insen PF08726.10 KOS17525.1 - 1.2e-26 92.5 1.2 3.6e-25 87.9 0.1 2.8 2 0 0 2 2 2 1 Ca2+ insensitive EF hand CAMSAP_CH PF11971.8 KOS17525.1 - 2.4e-13 49.7 0.2 1.1e-07 31.6 0.0 2.8 2 0 0 2 2 2 2 CAMSAP CH domain EF-hand_6 PF13405.6 KOS17525.1 - 6.5e-05 22.5 0.2 0.0019 18.0 0.0 3.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 KOS17525.1 - 0.00014 22.2 1.4 0.00014 22.2 1.4 2.7 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 KOS17525.1 - 0.00039 19.8 0.1 0.031 13.8 0.0 2.8 2 0 0 2 2 2 1 EF hand CH_2 PF06294.11 KOS17525.1 - 0.00067 19.7 0.0 0.056 13.6 0.0 3.2 3 0 0 3 3 3 1 CH-like domain in sperm protein EF-hand_8 PF13833.6 KOS17525.1 - 0.0015 18.3 0.5 0.038 13.9 0.0 3.0 1 1 2 3 3 3 1 EF-hand domain pair SHE3 PF17078.5 KOS17525.1 - 0.036 13.8 5.5 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 EMP24_GP25L PF01105.24 KOS17525.1 - 0.066 13.1 1.2 0.16 11.9 0.1 2.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD zf-RRPl_C4 PF17026.5 KOS17525.1 - 0.11 12.6 0.3 0.51 10.5 0.1 2.1 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type FliG_N PF14842.6 KOS17525.1 - 1.8 9.1 3.9 1.6 9.3 0.2 2.6 3 0 0 3 3 3 0 FliG N-terminal domain FAD-oxidase_C PF02913.19 KOS17526.1 - 1.8e-65 221.1 0.0 2.5e-65 220.6 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOS17526.1 - 7e-37 126.3 0.7 1.6e-36 125.1 0.7 1.6 1 0 0 1 1 1 1 FAD binding domain Ribosomal_L19 PF01245.20 KOS17527.1 - 1.4e-11 44.3 0.0 2.6e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L19 Ribosomal_S21e PF01249.18 KOS17529.1 - 2.3e-42 143.0 0.1 2.5e-42 142.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 KOS17529.1 - 0.035 14.0 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 Slx4 PF09494.10 KOS17530.1 - 8.9e-25 86.4 0.0 1.2e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Slx4 endonuclease DUF2521 PF10730.9 KOS17530.1 - 0.099 12.7 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) Ribosomal_L14 PF00238.19 KOS17531.1 - 8.3e-32 109.8 0.0 9.8e-32 109.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Cactin_mid PF10312.9 KOS17532.1 - 1.3e-59 201.2 7.6 1.9e-59 200.7 7.6 1.2 1 0 0 1 1 1 1 Conserved mid region of cactin CactinC_cactus PF09732.9 KOS17532.1 - 1.5e-55 186.5 4.0 1.5e-55 186.4 3.0 1.6 2 0 0 2 2 2 1 Cactus-binding C-terminus of cactin protein SF3A2 PF16835.5 KOS17532.1 - 0.016 15.5 0.0 0.042 14.2 0.0 1.7 1 0 0 1 1 1 0 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) DUF1087 PF06465.13 KOS17532.1 - 0.022 14.8 2.5 0.022 14.8 0.5 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) DUF5427 PF10310.9 KOS17533.1 - 3e-168 560.6 3.8 3.5e-168 560.3 3.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5427) DUF2722 PF10846.8 KOS17533.1 - 0.0011 18.0 15.4 0.002 17.2 15.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 KOS17533.1 - 0.0032 17.5 26.2 0.0052 16.8 26.2 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SARAF PF06682.12 KOS17533.1 - 0.0093 15.6 13.9 0.016 14.9 13.9 1.3 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 KOS17533.1 - 0.039 14.0 6.9 0.066 13.3 6.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GEN1_C PF18380.1 KOS17533.1 - 0.039 14.8 2.8 0.039 14.8 2.8 2.6 3 0 0 3 3 2 0 Holliday junction resolvase Gen1 C-terminal domain TERB2 PF15101.6 KOS17533.1 - 0.04 14.0 6.4 0.075 13.1 6.4 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 EPL1 PF10513.9 KOS17533.1 - 0.041 14.3 4.3 0.083 13.3 4.3 1.5 1 0 0 1 1 1 0 Enhancer of polycomb-like Ndc1_Nup PF09531.10 KOS17533.1 - 0.069 11.8 9.4 0.093 11.4 9.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DDHD PF02862.17 KOS17533.1 - 0.091 12.9 4.4 0.16 12.1 4.4 1.5 1 0 0 1 1 1 0 DDHD domain Virul_fac_BrkB PF03631.15 KOS17533.1 - 0.16 11.6 0.8 0.24 11.0 0.8 1.2 1 0 0 1 1 1 0 Virulence factor BrkB PIP5K PF01504.18 KOS17533.1 - 0.33 10.2 3.6 0.54 9.4 3.6 1.3 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF913 PF06025.12 KOS17533.1 - 0.59 9.1 3.9 0.95 8.4 3.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Spt20 PF12090.8 KOS17533.1 - 0.68 9.5 32.4 1.3 8.6 32.4 1.4 1 0 0 1 1 1 0 Spt20 family Connexin PF00029.19 KOS17533.1 - 0.77 9.5 3.1 1.1 8.9 3.1 1.2 1 0 0 1 1 1 0 Connexin Suf PF05843.14 KOS17533.1 - 0.82 9.6 13.1 1.3 9.0 13.1 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) PAT1 PF09770.9 KOS17533.1 - 1.1 7.4 16.0 1.5 7.0 16.0 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 KOS17533.1 - 1.2 8.9 9.8 2.1 8.1 9.8 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Roughex PF06020.11 KOS17533.1 - 1.7 7.7 10.3 2.9 6.9 10.3 1.4 1 0 0 1 1 1 0 Drosophila roughex protein eIF-3_zeta PF05091.12 KOS17533.1 - 2 7.3 13.2 2.7 6.9 13.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Band_3_cyto PF07565.13 KOS17533.1 - 2 8.2 6.7 3.1 7.5 6.7 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 KOS17533.1 - 2 7.3 6.9 2.8 6.9 6.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 KOS17533.1 - 2.2 7.0 11.8 3.1 6.5 11.8 1.3 1 0 0 1 1 1 0 Presenilin Paf1 PF03985.13 KOS17533.1 - 2.3 7.1 10.5 3.4 6.6 10.5 1.2 1 0 0 1 1 1 0 Paf1 SpoIIP PF07454.11 KOS17533.1 - 2.6 7.4 9.0 4.2 6.7 9.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) V_ATPase_I PF01496.19 KOS17533.1 - 3.2 5.5 6.5 4.5 5.1 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family VIR_N PF15912.5 KOS17533.1 - 3.5 7.2 7.6 5.8 6.4 7.6 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal EIIBC-GUT_N PF03612.14 KOS17533.1 - 4.5 7.0 7.5 8.9 6.0 7.5 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CW_binding_2 PF04122.12 KOS17534.1 - 0.25 12.0 3.8 0.71 10.6 3.8 1.7 1 0 0 1 1 1 0 Putative cell wall binding repeat 2 Clat_adaptor_s PF01217.20 KOS17535.1 - 1.1e-57 193.9 1.6 1.2e-57 193.8 1.6 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Ist1 PF03398.14 KOS17536.1 - 2e-58 196.9 0.2 2.4e-58 196.7 0.2 1.1 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway LCM PF04072.14 KOS17537.1 - 1.7e-18 67.3 0.0 6.8e-18 65.3 0.0 1.9 2 1 0 2 2 2 1 Leucine carboxyl methyltransferase TFIID-18kDa PF02269.16 KOS17538.1 - 7.3e-13 48.4 2.7 8.9e-12 44.9 0.3 2.9 3 0 0 3 3 3 1 Transcription initiation factor IID, 18kD subunit Myc_N PF01056.18 KOS17538.1 - 0.056 13.3 0.2 0.087 12.7 0.2 1.3 1 0 0 1 1 1 0 Myc amino-terminal region TAFII28 PF04719.14 KOS17538.1 - 0.11 12.6 0.1 0.31 11.2 0.1 1.8 1 1 0 1 1 1 0 hTAFII28-like protein conserved region Kinesin PF00225.23 KOS17539.1 - 8.3e-113 376.7 0.3 8.3e-113 376.7 0.3 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOS17539.1 - 9e-27 93.8 0.0 3.1e-26 92.1 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding RolB_RolC PF02027.17 KOS17539.1 - 0.56 9.9 4.4 0.64 9.7 0.2 2.5 2 0 0 2 2 2 0 RolB/RolC glucosidase family Thiolase_N PF00108.23 KOS17541.1 - 4.2e-82 275.4 1.6 7.8e-82 274.5 1.6 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS17541.1 - 8.1e-39 132.1 1.3 8.1e-39 132.1 1.3 2.0 2 0 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOS17541.1 - 4.1e-05 23.3 1.0 0.00011 21.9 0.4 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KOS17541.1 - 6.5 6.7 7.7 6 6.8 0.2 3.1 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III UQ_con PF00179.26 KOS17542.1 - 3.3e-52 175.9 0.1 3.7e-52 175.7 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS17542.1 - 0.0012 18.5 0.0 0.0014 18.3 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOS17542.1 - 0.011 16.1 0.0 0.014 15.6 0.0 1.4 1 1 0 1 1 1 0 RWD domain Pkinase PF00069.25 KOS17543.1 - 6.1e-22 78.2 0.0 8e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17543.1 - 5.5e-12 45.5 0.0 7.5e-12 45.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS17543.1 - 1.1e-07 31.0 0.0 1.6e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS17543.1 - 1.5e-05 25.1 0.2 4.9e-05 23.4 0.3 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 KOS17543.1 - 0.051 12.9 0.0 0.082 12.3 0.0 1.4 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family PDZ_1 PF12812.7 KOS17544.1 - 3.7e-53 177.5 0.1 1.1e-34 118.3 0.0 2.6 2 0 0 2 2 2 2 PDZ-like domain Trypsin_2 PF13365.6 KOS17544.1 - 2e-24 87.2 1.7 2.1e-20 74.1 0.3 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ_2 PF13180.6 KOS17544.1 - 7.2e-13 48.7 0.5 5.3e-05 23.5 0.0 4.4 4 0 0 4 4 4 3 PDZ domain PDZ_6 PF17820.1 KOS17544.1 - 1.2e-12 47.4 0.1 0.00077 19.3 0.0 3.9 4 0 0 4 4 4 3 PDZ domain PDZ PF00595.24 KOS17544.1 - 3.8e-09 36.8 0.0 3.6e-05 24.0 0.0 3.8 4 0 0 4 4 4 2 PDZ domain Trypsin PF00089.26 KOS17544.1 - 0.00019 21.3 0.0 0.0005 19.9 0.0 1.7 1 1 0 1 1 1 1 Trypsin Tricorn_PDZ PF14685.6 KOS17544.1 - 0.0077 16.2 0.1 1.4 9.0 0.0 3.3 3 0 0 3 3 3 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 KOS17544.1 - 0.074 11.7 0.3 0.22 10.1 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 4HPAD_g_N PF18671.1 KOS17544.1 - 0.085 12.6 0.0 0.24 11.1 0.0 1.8 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal Serine_rich PF08824.10 KOS17544.1 - 0.2 11.7 0.0 13 5.7 0.0 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain Myb_DNA-binding PF00249.31 KOS17545.1 - 0.084 13.1 0.2 0.26 11.5 0.1 1.9 2 0 0 2 2 2 0 Myb-like DNA-binding domain Peptidase_S49_N PF08496.10 KOS17545.1 - 0.099 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Nitroreductase PF00881.24 KOS17546.1 - 7.4e-19 68.4 0.0 9e-19 68.1 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family DnaJ_C PF01556.18 KOS17547.1 - 7.9e-38 129.9 0.0 1.1e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOS17547.1 - 3.7e-25 87.8 1.9 7.3e-25 86.9 1.9 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOS17547.1 - 1.2e-09 38.3 18.5 2.2e-09 37.5 18.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOS17547.1 - 0.00058 19.8 11.7 0.0055 16.6 1.4 2.7 2 0 0 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KOS17547.1 - 6.7 6.8 7.3 87 3.2 7.0 2.5 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SAP30_Sin3_bdg PF13867.6 KOS17548.1 - 3.1e-08 33.8 0.2 6.9e-08 32.7 0.0 1.6 2 0 0 2 2 2 1 Sin3 binding region of histone deacetylase complex subunit SAP30 DEAD PF00270.29 KOS17549.1 - 6.2e-47 159.6 0.0 1.8e-46 158.1 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17549.1 - 1.7e-24 86.3 0.0 2.1e-23 82.8 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 KOS17549.1 - 2.9e-22 78.7 1.3 9e-22 77.1 1.3 1.9 1 0 0 1 1 1 1 DBP10CT (NUC160) domain ResIII PF04851.15 KOS17549.1 - 3.8e-06 27.0 0.0 8.1e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DnaJ PF00226.31 KOS17550.1 - 1.8e-13 50.4 0.1 1.8e-13 50.4 0.1 2.7 3 1 0 3 3 3 1 DnaJ domain Herpes_env PF01673.18 KOS17550.1 - 0.48 9.3 2.8 0.57 9.0 2.8 1.1 1 0 0 1 1 1 0 Herpesvirus putative major envelope glycoprotein ALMT PF11744.8 KOS17550.1 - 3.6 6.3 5.2 4.8 5.9 5.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pex2_Pex12 PF04757.14 KOS17551.1 - 1.8e-50 171.7 4.0 2.6e-50 171.1 4.0 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 KOS17551.1 - 0.0022 18.1 2.5 0.004 17.3 2.5 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOS17551.1 - 0.0056 17.0 3.5 0.0098 16.2 3.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOS17551.1 - 0.012 15.4 1.9 0.02 14.8 1.9 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17551.1 - 0.036 13.9 2.7 0.062 13.2 2.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS17551.1 - 0.092 12.6 2.0 0.16 11.8 2.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS17551.1 - 0.11 12.6 1.6 0.21 11.6 1.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Pns11_12 PF17464.2 KOS17551.1 - 0.29 10.8 1.9 0.45 10.2 1.9 1.2 1 0 0 1 1 1 0 Non-structural protein 11 and 12 CobT PF06213.12 KOS17551.1 - 9.6 5.5 10.3 13 5.0 10.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT WSC PF01822.19 KOS17552.1 - 8.1e-11 42.0 7.4 8.1e-11 42.0 7.4 2.1 2 0 0 2 2 2 1 WSC domain Glyco_hydro_16 PF00722.21 KOS17552.1 - 4.2e-05 23.1 0.1 0.0001 21.9 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 cNMP_binding PF00027.29 KOS17553.1 - 3.4e-33 113.6 0.0 4e-19 68.5 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain cNMPbd_u2 PF16643.5 KOS17553.1 - 1.1e-20 74.6 13.0 6.8e-20 72.1 13.0 2.2 1 1 0 1 1 1 1 Unstructured region on cNMP-binding protein LRR_6 PF13516.6 KOS17553.1 - 3.5e-09 36.0 3.7 0.52 10.5 0.0 6.3 6 0 0 6 6 6 3 Leucine Rich repeat F-box PF00646.33 KOS17553.1 - 3.9e-08 33.0 0.6 3.9e-08 33.0 0.6 2.7 3 0 0 3 3 3 1 F-box domain LRR_4 PF12799.7 KOS17553.1 - 4.3e-07 30.1 0.1 0.051 14.0 0.0 4.2 3 0 0 3 3 3 2 Leucine Rich repeats (2 copies) F-box-like PF12937.7 KOS17553.1 - 3.8e-05 23.5 1.6 8e-05 22.5 0.2 2.3 2 0 0 2 2 2 1 F-box-like Cupin_3 PF05899.12 KOS17553.1 - 0.066 12.9 0.1 4.5 7.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF861) LRR_1 PF00560.33 KOS17553.1 - 0.13 12.9 9.2 12 6.9 0.0 6.4 7 0 0 7 7 7 0 Leucine Rich Repeat Noc2 PF03715.13 KOS17554.1 - 2.6e-124 414.3 0.0 4.1e-124 413.7 0.0 1.3 1 0 0 1 1 1 1 Noc2p family Nop14 PF04147.12 KOS17554.1 - 2.7e-06 26.0 0.1 2.7e-06 26.0 0.1 4.0 2 2 1 3 3 3 1 Nop14-like family Cep57_CLD_2 PF14197.6 KOS17555.1 - 2.9e-26 91.3 65.0 2.8e-13 49.7 4.9 6.2 4 1 3 7 7 6 4 Centrosome localisation domain of PPC89 Cep57_MT_bd PF06657.13 KOS17555.1 - 4e-26 91.3 0.5 4e-26 91.3 0.5 6.2 5 1 1 6 6 6 1 Centrosome microtubule-binding domain of Cep57 HALZ PF02183.18 KOS17555.1 - 2.3e-06 27.7 52.4 0.015 15.5 1.2 9.6 7 2 3 10 10 10 5 Homeobox associated leucine zipper KASH_CCD PF14662.6 KOS17555.1 - 9.8e-05 22.3 57.2 0.0046 16.8 18.3 4.4 2 1 2 4 4 4 2 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 KOS17555.1 - 0.00026 21.5 58.5 0.018 15.6 12.3 4.5 2 1 2 4 4 4 2 Apg6 coiled-coil region Spc7 PF08317.11 KOS17555.1 - 0.0013 17.7 19.4 0.0013 17.7 19.4 3.8 2 1 2 4 4 4 1 Spc7 kinetochore protein ZapB PF06005.12 KOS17555.1 - 0.0026 18.2 60.8 0.0065 16.9 7.0 7.6 3 2 3 7 7 7 3 Cell division protein ZapB CENP-F_leu_zip PF10473.9 KOS17555.1 - 0.007 16.4 55.2 0.13 12.3 16.2 4.1 2 1 2 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSC22 PF01166.18 KOS17555.1 - 0.015 15.6 31.5 0.15 12.4 0.3 6.7 4 2 3 7 7 6 0 TSC-22/dip/bun family YabA PF06156.13 KOS17555.1 - 0.016 15.8 44.0 0.35 11.5 3.7 7.2 2 2 4 6 6 6 0 Initiation control protein YabA Fungal_TACC PF12709.7 KOS17555.1 - 0.11 13.0 34.7 0.19 12.2 2.0 7.0 1 1 5 7 7 7 0 Fungal Transforming acidic coiled-coil (TACC) proteins DivIC PF04977.15 KOS17555.1 - 0.27 11.0 48.6 0.84 9.5 2.0 7.2 3 2 4 7 7 6 0 Septum formation initiator DUF730 PF05325.11 KOS17555.1 - 0.28 11.2 6.0 47 4.0 0.1 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF730) JIP_LZII PF16471.5 KOS17555.1 - 0.35 11.1 36.4 0.36 11.0 5.0 6.4 2 2 3 6 6 6 0 JNK-interacting protein leucine zipper II DUF1192 PF06698.11 KOS17555.1 - 0.51 10.4 13.1 3.2 7.9 0.1 5.9 6 0 0 6 6 6 0 Protein of unknown function (DUF1192) Lebercilin PF15619.6 KOS17555.1 - 1.1 8.9 58.6 0.64 9.7 20.2 5.7 2 1 2 5 5 5 0 Ciliary protein causing Leber congenital amaurosis disease Tup_N PF08581.10 KOS17555.1 - 1.1 9.6 32.2 0.064 13.6 1.0 6.0 3 1 2 5 5 5 0 Tup N-terminal Rootletin PF15035.6 KOS17555.1 - 1.6 8.7 55.6 0.88 9.6 0.1 5.3 2 1 2 5 5 4 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 KOS17555.1 - 1.9 8.7 41.8 0.065 13.3 0.9 7.6 3 2 8 11 11 10 0 bZIP transcription factor DUF2353 PF09789.9 KOS17555.1 - 2.3 7.5 57.7 0.58 9.5 21.8 3.7 2 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) Filament PF00038.21 KOS17555.1 - 4.2 6.9 49.5 0.3 10.6 14.3 3.7 2 1 1 4 4 4 0 Intermediate filament protein HAP1_N PF04849.13 KOS17555.1 - 4.6 6.3 55.2 0.72 9.0 31.2 4.6 2 1 2 4 4 4 0 HAP1 N-terminal conserved region TPR_MLP1_2 PF07926.12 KOS17555.1 - 5.4 7.1 50.8 5.2 7.1 16.3 5.4 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Csm1_N PF18504.1 KOS17555.1 - 5.7 7.4 55.0 0.37 11.2 0.3 7.5 4 1 3 8 8 7 0 Csm1 N-terminal domain DUF1664 PF07889.12 KOS17555.1 - 6 6.9 28.6 8.8 6.4 4.6 5.1 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) DUF4472 PF14739.6 KOS17555.1 - 6.3 7.6 44.2 0.15 12.8 6.8 6.2 2 1 3 6 6 6 0 Domain of unknown function (DUF4472) CALCOCO1 PF07888.11 KOS17555.1 - 6.6 5.5 58.8 0.3 9.9 43.4 3.5 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like RXT2_N PF08595.11 KOS17557.1 - 0.003 17.6 10.3 0.016 15.2 4.6 2.3 2 0 0 2 2 2 2 RXT2-like, N-terminal NOA36 PF06524.12 KOS17557.1 - 0.0037 16.6 11.6 0.0037 16.6 11.6 2.1 2 0 0 2 2 2 1 NOA36 protein FAM176 PF14851.6 KOS17557.1 - 2.6 7.7 14.1 3.7 7.2 0.8 2.3 2 0 0 2 2 2 0 FAM176 family PH PF00169.29 KOS17559.1 - 0.0001 22.7 0.1 0.00029 21.3 0.0 1.8 2 0 0 2 2 2 1 PH domain Prominin PF05478.11 KOS17559.1 - 0.053 11.5 0.2 0.071 11.1 0.2 1.1 1 0 0 1 1 1 0 Prominin WEMBL PF05701.11 KOS17559.1 - 0.06 12.0 3.3 0.11 11.2 3.3 1.4 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Gar1 PF04410.14 KOS17560.1 - 7e-37 126.6 0.1 8.5e-37 126.3 0.1 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region LCAT PF02450.15 KOS17561.1 - 1.2e-102 344.0 0.0 1.5e-102 343.7 0.0 1.1 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF2013 PF09431.10 KOS17562.1 - 1.5e-50 171.0 1.4 3.5e-50 169.8 1.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Ysc84 PF04366.12 KOS17563.1 - 2e-45 153.6 0.0 3.2e-45 153.0 0.0 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator VPS28 PF03997.12 KOS17564.1 - 5.8e-67 225.0 0.0 7e-67 224.8 0.0 1.1 1 0 0 1 1 1 1 VPS28 protein KH_8 PF17903.1 KOS17565.1 - 6.5e-31 106.3 0.0 1.5e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 Krr1 KH1 domain Acyltransf_C PF16076.5 KOS17565.1 - 0.05 13.7 0.2 0.52 10.5 0.2 2.4 2 0 0 2 2 2 0 Acyltransferase C-terminus KH_1 PF00013.29 KOS17565.1 - 0.056 13.3 0.0 0.17 11.7 0.0 1.9 2 0 0 2 2 2 0 KH domain ADH_zinc_N PF00107.26 KOS17566.1 - 2.4e-17 63.1 0.2 3.7e-17 62.5 0.2 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS17566.1 - 1.6e-08 35.7 0.0 4.9e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Glyco_hydro_61 PF03443.14 KOS17567.1 - 1.5e-42 145.8 0.0 2.6e-42 145.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 61 Cpn10 PF00166.21 KOS17568.1 - 4.8e-30 103.5 0.0 5.5e-30 103.3 0.0 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit Pkinase PF00069.25 KOS17569.1 - 5.6e-48 163.6 0.0 4.2e-47 160.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17569.1 - 3.1e-21 75.8 0.0 6.8e-21 74.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KOS17569.1 - 0.001 19.0 0.1 0.0075 16.2 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS17569.1 - 0.1 11.6 0.0 0.1 11.6 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain DUF2781 PF10914.8 KOS17569.1 - 0.11 12.9 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) Ribosomal_L11 PF00298.19 KOS17570.1 - 3.3e-26 91.6 0.5 5.1e-26 91.0 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain Ribosomal_L11_N PF03946.14 KOS17570.1 - 5.4e-26 90.2 0.2 8.7e-26 89.6 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain AAA PF00004.29 KOS17571.1 - 7.7e-51 172.0 0.0 4.5e-39 133.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS17571.1 - 2.4e-15 56.1 5.6 2.2e-12 46.6 1.8 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 KOS17571.1 - 5.4e-07 30.1 0.5 0.022 15.1 0.4 4.2 3 2 1 4 4 4 2 AAA ATPase domain RuvB_N PF05496.12 KOS17571.1 - 0.00025 20.8 0.0 0.0023 17.7 0.0 2.6 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOS17571.1 - 0.00025 21.0 0.1 0.23 11.5 0.0 3.6 2 2 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS17571.1 - 0.00035 20.9 0.0 0.55 10.5 0.0 3.3 2 1 1 3 3 3 1 AAA domain AAA_28 PF13521.6 KOS17571.1 - 0.0049 17.1 0.0 0.067 13.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOS17571.1 - 0.0076 16.3 0.0 4.1 7.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 KOS17571.1 - 0.0085 16.2 0.0 0.51 10.5 0.0 2.7 3 0 0 3 3 2 1 Sigma-54 interaction domain AAA_25 PF13481.6 KOS17571.1 - 0.027 14.0 2.3 13 5.3 0.1 3.7 2 2 2 4 4 4 0 AAA domain RNA_helicase PF00910.22 KOS17571.1 - 0.028 14.8 0.0 4.3 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Vps4_C PF09336.10 KOS17571.1 - 0.055 13.5 0.2 20 5.3 0.0 3.2 4 0 0 4 4 2 0 Vps4 C terminal oligomerisation domain IstB_IS21 PF01695.17 KOS17571.1 - 0.064 13.0 0.0 10 5.8 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 KOS17571.1 - 0.066 13.7 0.0 0.14 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 KOS17571.1 - 0.098 12.8 0.0 0.69 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 KOS17571.1 - 0.11 12.8 0.0 1.9 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 KOS17571.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 KOS17571.1 - 0.16 11.3 0.1 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KOS17571.1 - 0.23 11.4 3.0 8 6.4 0.2 3.1 2 1 1 3 3 3 0 NACHT domain Trypan_PARP PF05887.11 KOS17572.1 - 0.34 10.9 4.0 0.34 10.9 2.3 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ras PF00071.22 KOS17573.1 - 3.1e-64 215.5 0.0 3.8e-64 215.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS17573.1 - 4.3e-34 117.3 0.1 6.3e-34 116.8 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS17573.1 - 3.3e-13 49.5 0.0 3.9e-13 49.2 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS17573.1 - 8.3e-06 25.5 0.0 1.8e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOS17573.1 - 0.00022 20.6 0.0 0.00024 20.5 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS17573.1 - 0.0033 17.5 0.0 0.0071 16.4 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS17573.1 - 0.007 16.3 0.2 2.7 7.9 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 KOS17573.1 - 0.043 13.2 0.0 0.051 13.0 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 KOS17573.1 - 0.1 12.1 0.0 0.48 9.9 0.0 2.0 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA PF00004.29 KOS17573.1 - 0.13 12.7 0.0 7.5 7.0 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS17573.1 - 0.19 12.0 0.1 0.48 10.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain U-box PF04564.15 KOS17574.1 - 4.1e-06 26.9 0.0 7.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 U-box domain RPAP1_N PF08621.10 KOS17574.1 - 0.15 11.8 0.2 0.95 9.3 0.1 2.2 3 0 0 3 3 3 0 RPAP1-like, N-terminal zf-Nse PF11789.8 KOS17574.1 - 0.19 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Malic_M PF03949.15 KOS17575.1 - 5.3e-73 245.5 0.0 7.9e-73 244.9 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KOS17575.1 - 2.4e-57 193.7 0.0 3.5e-57 193.2 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain MA3 PF02847.17 KOS17576.1 - 3.4e-24 85.0 0.0 1e-23 83.4 0.0 1.9 2 0 0 2 2 2 1 MA3 domain MIF4G PF02854.19 KOS17576.1 - 1.9e-09 37.5 1.0 3e-09 36.8 0.1 1.8 2 0 0 2 2 2 1 MIF4G domain FAM176 PF14851.6 KOS17576.1 - 0.17 11.6 4.4 2.3 7.9 4.2 2.8 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.14 KOS17576.1 - 1.2 7.4 12.7 0.12 10.6 5.6 2.2 2 0 0 2 2 2 0 CDC45-like protein DNA_pol_phi PF04931.13 KOS17576.1 - 8.4 4.4 13.6 15 3.5 13.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi adh_short PF00106.25 KOS17577.1 - 3.6e-30 104.9 0.1 4.4e-30 104.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS17577.1 - 1.1e-25 90.5 0.1 1.3e-25 90.3 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS17577.1 - 9.6e-09 35.4 4.5 4.7e-08 33.1 4.0 2.2 1 1 0 1 1 1 1 KR domain PTB PF08416.13 KOS17577.1 - 0.11 12.7 0.1 2.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Phosphotyrosine-binding domain RcpC PF16976.5 KOS17578.1 - 0.3 11.1 1.7 6 7.0 0.8 2.8 2 0 0 2 2 2 0 Flp pilus assembly protein RcpC/CpaB ING PF12998.7 KOS17579.1 - 0.00025 21.6 3.4 0.00073 20.1 0.0 2.9 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KOS17579.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 2.6 2 0 0 2 2 2 1 PHD-finger Bactofilin PF04519.13 KOS17580.1 - 1.1e-07 32.1 0.4 0.0006 20.1 0.2 2.3 1 1 1 2 2 2 2 Polymer-forming cytoskeletal FapA PF03961.13 KOS17580.1 - 0.00015 20.6 1.0 0.00022 20.0 1.0 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A MinC_C PF03775.16 KOS17580.1 - 0.00057 19.8 1.4 0.2 11.7 0.1 2.8 1 1 2 3 3 3 3 Septum formation inhibitor MinC, C-terminal domain DUF748 PF05359.11 KOS17580.1 - 0.02 15.1 0.0 0.52 10.5 0.0 2.4 1 1 2 3 3 3 0 Domain of Unknown Function (DUF748) Sugar_tr PF00083.24 KOS17581.1 - 1.3e-76 258.3 18.7 1.5e-76 258.1 18.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17581.1 - 2.8e-29 102.1 29.6 4.4e-25 88.4 16.6 2.0 1 1 0 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOS17581.1 - 3.4e-06 25.8 1.2 3.4e-06 25.8 1.2 1.7 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Tetraspanin PF00335.20 KOS17581.1 - 0.039 13.6 5.4 0.049 13.3 0.0 2.6 2 0 0 2 2 2 0 Tetraspanin family MSP1b PF03429.13 KOS17581.1 - 0.11 10.6 0.1 0.16 10.0 0.1 1.1 1 0 0 1 1 1 0 Major surface protein 1B VASt PF16016.5 KOS17582.1 - 1.1e-35 123.3 0.0 2e-35 122.5 0.0 1.4 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 KOS17582.1 - 4e-23 81.5 0.0 6.5e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 GRAM domain SR-25 PF10500.9 KOS17583.1 - 0.0067 16.1 0.6 0.0083 15.8 0.6 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Nup_retrotrp_bd PF10599.9 KOS17583.1 - 0.022 15.4 8.5 0.036 14.7 8.5 1.3 1 0 0 1 1 1 0 Retro-transposon transporting motif REC114-like PF15165.6 KOS17584.1 - 0.69 9.6 0.0 0.69 9.6 0.0 5.3 2 1 2 4 4 4 0 Meiotic recombination protein REC114-like zinc_ribbon_9 PF14369.6 KOS17585.1 - 0.33 11.2 3.3 1.3 9.3 3.3 2.2 1 0 0 1 1 1 0 zinc-ribbon AAA_6 PF12774.7 KOS17586.1 - 3.7e-126 420.5 0.0 2.1e-125 418.0 0.0 2.5 3 0 0 3 3 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 KOS17586.1 - 5.3e-116 388.0 7.6 5.3e-116 388.0 7.6 5.2 4 2 0 4 4 3 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 KOS17586.1 - 9.2e-113 377.8 8.4 9.2e-113 377.8 8.4 4.4 5 1 0 5 5 5 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 KOS17586.1 - 2.4e-74 249.2 0.6 2.4e-74 249.2 0.6 2.9 2 0 0 2 2 2 1 ATP-binding dynein motor region AAA_8 PF12780.7 KOS17586.1 - 8.7e-66 221.9 0.0 3.5e-65 219.9 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 KOS17586.1 - 2.6e-42 144.4 0.0 4.4e-36 124.1 0.0 4.7 5 0 0 5 5 4 2 P-loop containing dynein motor region MT PF12777.7 KOS17586.1 - 1.1e-39 136.5 10.9 2.4e-39 135.3 10.9 1.6 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 KOS17586.1 - 5.2e-32 110.7 0.0 1.9e-12 47.4 0.0 6.4 5 1 0 5 5 4 4 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 KOS17586.1 - 7.9e-30 103.4 0.0 3.2e-27 95.0 0.0 3.5 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 KOS17586.1 - 3e-28 98.7 0.0 7.4e-28 97.4 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_22 PF13401.6 KOS17586.1 - 3.3e-14 53.3 1.1 0.01 16.1 0.0 6.2 5 1 1 6 6 5 3 AAA domain AAA PF00004.29 KOS17586.1 - 1.2e-13 51.6 0.0 0.004 17.6 0.0 5.2 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) Dynein_AAA_lid PF17852.1 KOS17586.1 - 1.4e-13 51.0 0.0 5.3e-13 49.2 0.0 2.1 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_18 PF13238.6 KOS17586.1 - 3.8e-10 40.4 0.8 0.07 13.7 0.0 5.9 5 0 0 5 5 4 2 AAA domain AAA_33 PF13671.6 KOS17586.1 - 3.6e-09 36.9 3.7 0.26 11.4 0.0 5.5 5 0 0 5 5 4 3 AAA domain AAA_16 PF13191.6 KOS17586.1 - 5.2e-09 36.7 8.3 0.45 10.9 0.0 7.9 9 0 0 9 9 5 2 AAA ATPase domain AAA_lid_1 PF17857.1 KOS17586.1 - 5.4e-06 26.6 0.4 8.9e-05 22.6 0.0 3.3 3 0 0 3 3 2 1 AAA+ lid domain T2SSE PF00437.20 KOS17586.1 - 2.3e-05 23.6 0.0 0.041 13.0 0.0 3.6 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_29 PF13555.6 KOS17586.1 - 9.9e-05 22.0 0.1 2.3 8.0 0.0 3.7 3 0 0 3 3 3 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KOS17586.1 - 0.00014 22.4 0.5 5.1 7.6 0.0 5.1 4 0 0 4 4 3 0 ABC transporter Mg_chelatase PF01078.21 KOS17586.1 - 0.00027 20.4 1.2 0.68 9.3 0.0 3.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Pil1 PF13805.6 KOS17586.1 - 0.0006 19.4 0.8 0.0006 19.4 0.8 2.9 2 0 0 2 2 1 1 Eisosome component PIL1 AAA_19 PF13245.6 KOS17586.1 - 0.00066 20.0 1.1 0.28 11.5 0.0 4.3 4 0 0 4 4 4 1 AAA domain IstB_IS21 PF01695.17 KOS17586.1 - 0.0025 17.6 0.9 0.72 9.6 0.0 4.3 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_24 PF13479.6 KOS17586.1 - 0.0026 17.5 0.5 10 5.8 0.0 4.3 4 0 0 4 4 4 0 AAA domain Taxilin PF09728.9 KOS17586.1 - 0.003 16.8 1.0 0.003 16.8 1.0 4.0 3 0 0 3 3 2 1 Myosin-like coiled-coil protein FtsK_SpoIIIE PF01580.18 KOS17586.1 - 0.0034 16.8 0.0 2.4 7.5 0.0 3.8 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_25 PF13481.6 KOS17586.1 - 0.0036 16.9 0.7 0.25 10.9 0.0 3.5 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 KOS17586.1 - 0.0043 17.4 0.1 17 5.9 0.0 4.8 4 0 0 4 4 4 0 RNA helicase DUF4482 PF14818.6 KOS17586.1 - 0.029 15.2 7.6 27 5.6 0.0 3.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) Rad17 PF03215.15 KOS17586.1 - 0.035 14.0 0.1 7 6.5 0.0 3.9 4 0 0 4 4 3 0 Rad17 P-loop domain Zeta_toxin PF06414.12 KOS17586.1 - 0.041 13.2 0.2 24 4.1 0.1 4.0 4 0 0 4 4 4 0 Zeta toxin NTPase_1 PF03266.15 KOS17586.1 - 0.13 12.2 0.0 44 3.9 0.0 3.9 3 0 0 3 3 3 0 NTPase Phage_GP20 PF06810.11 KOS17586.1 - 0.32 10.8 23.7 1.9 8.3 0.3 5.0 4 1 0 4 4 4 0 Phage minor structural protein GP20 PduV-EutP PF10662.9 KOS17586.1 - 1 9.1 3.0 11 5.7 0.1 3.9 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 KOS17586.1 - 2 8.3 5.6 32 4.4 0.0 4.3 4 0 0 4 4 3 0 NACHT domain ACPS PF01648.20 KOS17588.1 - 0.004 17.3 0.0 0.0047 17.1 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily DUF1774 PF08611.10 KOS17589.1 - 1.1e-35 121.8 1.1 1.1e-35 121.8 1.1 2.7 3 1 0 3 3 3 1 Fungal protein of unknown function (DUF1774) Smim3 PF17307.2 KOS17589.1 - 0.48 10.0 4.1 13 5.4 0.0 2.5 2 0 0 2 2 2 0 Small integral membrane protein 3 CENP-Q PF13094.6 KOS17590.1 - 1.6e-05 25.2 19.1 4.4e-05 23.7 6.1 3.5 3 1 0 3 3 3 2 CENP-Q, a CENPA-CAD centromere complex subunit GIT_CC PF16559.5 KOS17590.1 - 0.0023 17.8 2.4 0.12 12.3 0.3 2.5 2 0 0 2 2 2 1 GIT coiled-coil Rho guanine nucleotide exchange factor APG6_N PF17675.1 KOS17590.1 - 0.0028 18.2 2.9 0.0028 18.2 2.9 2.7 3 1 0 3 3 2 1 Apg6 coiled-coil region KASH_CCD PF14662.6 KOS17590.1 - 0.003 17.4 11.2 0.15 11.8 5.9 2.6 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH Sec34 PF04136.15 KOS17590.1 - 0.0039 17.1 3.5 0.74 9.7 0.1 2.5 2 0 0 2 2 2 2 Sec34-like family Cnn_1N PF07989.11 KOS17590.1 - 0.0046 17.1 8.0 0.022 14.9 0.6 2.8 3 0 0 3 3 2 1 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 KOS17590.1 - 0.0062 16.6 10.8 0.72 10.0 0.1 3.3 3 0 0 3 3 3 2 bZIP transcription factor betaPIX_CC PF16523.5 KOS17590.1 - 0.031 14.1 5.2 0.31 10.9 1.2 2.5 2 0 0 2 2 2 0 betaPIX coiled coil Ax_dynein_light PF10211.9 KOS17590.1 - 0.035 14.0 13.7 0.42 10.5 0.1 2.7 3 0 0 3 3 3 0 Axonemal dynein light chain Herpes_UL6 PF01763.16 KOS17590.1 - 0.037 12.5 3.7 0.03 12.9 1.1 1.9 1 1 1 2 2 2 0 Herpesvirus UL6 like SHE3 PF17078.5 KOS17590.1 - 0.16 11.6 9.0 1.6 8.4 2.4 2.5 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 JIP_LZII PF16471.5 KOS17590.1 - 0.23 11.7 10.1 3.3 7.9 0.4 2.5 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II SOGA PF11365.8 KOS17590.1 - 0.23 12.6 10.4 0.087 14.0 2.9 3.0 3 0 0 3 3 3 0 Protein SOGA MRPL52 PF18699.1 KOS17590.1 - 0.38 11.0 6.4 5.3 7.3 3.5 2.6 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Dor1 PF04124.12 KOS17590.1 - 0.38 9.4 9.0 0.21 10.3 1.3 3.0 3 0 0 3 3 3 0 Dor1-like family Jnk-SapK_ap_N PF09744.9 KOS17590.1 - 0.52 10.5 14.4 1.7 8.8 5.0 3.0 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 TolA_bind_tri PF16331.5 KOS17590.1 - 0.77 9.9 8.4 6.8 6.8 0.7 3.1 3 0 0 3 3 3 0 TolA binding protein trimerisation DUF4446 PF14584.6 KOS17590.1 - 0.81 9.7 5.4 1.7 8.6 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) GAS PF13851.6 KOS17590.1 - 1.3 8.3 15.1 0.47 9.8 6.5 2.6 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 KOS17590.1 - 1.6 8.7 18.3 2.1 8.4 6.5 3.1 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4795 PF16043.5 KOS17590.1 - 1.7 8.2 9.1 1 9.0 2.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) Lebercilin PF15619.6 KOS17590.1 - 3.5 7.2 16.2 0.23 11.1 0.2 2.7 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Fib_alpha PF08702.10 KOS17590.1 - 3.9 7.6 8.7 1.5 9.0 1.7 2.6 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family Prefoldin_2 PF01920.20 KOS17590.1 - 4.1 7.4 14.8 0.26 11.3 4.1 2.9 3 0 0 3 3 2 0 Prefoldin subunit Spc24 PF08286.11 KOS17590.1 - 4.8 7.5 12.6 7.1 6.9 4.0 2.9 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 STAT_alpha PF01017.20 KOS17590.1 - 5.4 6.9 9.0 0.64 9.9 1.5 2.5 3 0 0 3 3 3 0 STAT protein, all-alpha domain Prefoldin PF02996.17 KOS17590.1 - 7.1 6.6 10.1 19 5.2 0.2 3.2 3 0 0 3 3 3 0 Prefoldin subunit YabA PF06156.13 KOS17590.1 - 9.8 6.9 11.1 4.9 7.8 3.0 2.7 3 0 0 3 3 2 0 Initiation control protein YabA Cupin_8 PF13621.6 KOS17591.1 - 5.3e-29 101.7 0.0 7.9e-29 101.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOS17591.1 - 5.8e-05 22.7 0.0 0.0019 17.7 0.0 2.2 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 KOS17591.1 - 6.7e-05 23.3 0.0 0.00034 21.0 0.0 1.9 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 KOS17591.1 - 0.049 13.4 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 Cupin domain SF3b10 PF07189.11 KOS17592.1 - 5.9e-29 100.0 0.0 7.5e-29 99.7 0.0 1.1 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Rpn3_C PF08375.11 KOS17593.1 - 1e-26 93.1 2.2 3.3e-26 91.5 2.2 1.9 1 0 0 1 1 1 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 KOS17593.1 - 5.8e-21 75.0 0.4 3e-20 72.7 0.0 2.3 3 0 0 3 3 3 1 PCI domain TPR_2 PF07719.17 KOS17593.1 - 0.0071 16.4 0.1 0.024 14.7 0.1 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TFIID_20kDa PF03847.13 KOS17594.1 - 6.9e-17 61.7 0.0 1.1e-16 61.1 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DASH_Spc34 PF08657.10 KOS17595.1 - 6.4e-48 163.8 10.6 2.4e-23 83.3 0.0 2.1 1 1 1 2 2 2 2 DASH complex subunit Spc34 Ribosomal_60s PF00428.19 KOS17595.1 - 0.012 16.2 7.2 0.012 16.2 7.2 2.5 3 0 0 3 3 2 0 60s Acidic ribosomal protein Nop14 PF04147.12 KOS17595.1 - 0.61 8.2 13.3 0.85 7.8 13.3 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOS17595.1 - 0.91 8.8 9.0 1.4 8.1 9.0 1.3 1 0 0 1 1 1 0 NOA36 protein TMEM171 PF15471.6 KOS17595.1 - 0.96 8.4 2.0 1.2 8.0 1.1 1.6 2 0 0 2 2 2 0 Transmembrane protein family 171 CPSF100_C PF13299.6 KOS17595.1 - 1.1 9.4 5.3 1.3 9.2 2.7 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Vfa1 PF08432.10 KOS17595.1 - 2 8.7 6.3 0.45 10.8 2.7 1.7 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 KOS17595.1 - 3 6.7 4.7 0.98 8.3 1.6 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Astro_capsid_p PF12226.8 KOS17595.1 - 4.3 6.4 6.4 6.8 5.7 6.4 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DASH_Spc19 PF08287.11 KOS17595.1 - 4.4 7.2 11.1 0.89 9.4 6.7 1.9 2 0 0 2 2 2 0 Spc19 CDC45 PF02724.14 KOS17595.1 - 5.5 5.2 17.6 0.56 8.4 12.9 1.6 2 0 0 2 2 2 0 CDC45-like protein Pes-10 PF07149.11 KOS17595.1 - 8 5.4 15.5 12 4.9 15.5 1.2 1 0 0 1 1 1 0 Pes-10 zf-RING_2 PF13639.6 KOS17596.1 - 4.6e-09 36.5 11.5 9.6e-09 35.4 11.5 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOS17596.1 - 5.2e-07 29.4 8.7 8.8e-07 28.7 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS17596.1 - 4.5e-06 26.4 8.1 6.9e-06 25.8 8.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS17596.1 - 1.2e-05 25.1 11.3 2.3e-05 24.1 11.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS17596.1 - 0.00018 21.7 9.6 0.00059 20.1 9.6 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 KOS17596.1 - 0.17 11.7 3.7 0.4 10.5 3.7 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 KOS17596.1 - 1.2 9.1 10.2 2.1 8.4 10.2 1.4 1 0 0 1 1 1 0 zinc-RING finger domain DNA_pol_A_exo1 PF01612.20 KOS17597.1 - 1.9e-39 135.2 0.3 3e-39 134.6 0.3 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 KOS17597.1 - 2.2e-25 89.1 0.9 2.2e-25 89.1 0.9 2.5 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 KOS17597.1 - 3.6e-12 46.1 0.0 9.4e-12 44.8 0.0 1.8 1 0 0 1 1 1 1 HRDC domain Casc1 PF12366.8 KOS17597.1 - 0.026 14.0 0.0 0.026 14.0 0.0 2.0 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 YL1 PF05764.13 KOS17597.1 - 0.31 11.1 27.9 0.036 14.2 23.2 1.7 2 0 0 2 2 2 0 YL1 nuclear protein ATP-synt_C PF00137.21 KOS17598.1 - 6e-11 42.5 11.9 1.2e-10 41.5 11.9 1.6 1 0 0 1 1 1 1 ATP synthase subunit C Synthase_beta PF11421.8 KOS17598.1 - 3 8.6 7.2 6.9 7.5 7.2 1.6 1 0 0 1 1 1 0 ATP synthase F1 beta subunit MOZ_SAS PF01853.18 KOS17599.1 - 1.4e-53 181.2 0.0 3.7e-51 173.3 0.0 2.2 2 0 0 2 2 2 2 MOZ/SAS family zf-MYST PF17772.1 KOS17599.1 - 6e-09 35.4 0.4 0.003 17.1 0.0 2.4 2 0 0 2 2 2 2 MYST family zinc finger domain LRR_6 PF13516.6 KOS17600.1 - 1.2e-10 40.5 0.6 1.9 8.7 0.0 7.6 8 0 0 8 8 8 3 Leucine Rich repeat 5_nucleotid_C PF02872.18 KOS17601.1 - 1.6e-30 106.4 0.0 2.7e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 KOS17601.1 - 1.2e-12 48.8 1.0 2.2e-12 47.9 1.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase YmdB PF13277.6 KOS17601.1 - 0.016 14.5 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 YmdB-like protein Glyco_transf_20 PF00982.21 KOS17602.1 - 6.1e-197 655.0 0.0 6.9e-197 654.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_transf_5 PF08323.11 KOS17602.1 - 0.079 12.6 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 Starch synthase catalytic domain Mis14 PF08641.12 KOS17603.1 - 3.4e-12 46.8 0.0 2.1e-11 44.2 0.0 2.2 2 1 1 3 3 3 1 Kinetochore protein Mis14 like Aminotran_3 PF00202.21 KOS17604.1 - 1.3e-41 142.6 0.1 1.5e-41 142.4 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOS17604.1 - 0.06 12.6 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Beta-eliminating lyase AIRC PF00731.20 KOS17605.1 - 2.1e-61 205.8 0.7 5.1e-61 204.6 0.7 1.7 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 KOS17605.1 - 2.3e-48 164.0 0.1 4.9e-48 162.9 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain PurK_C PF17769.1 KOS17605.1 - 3.1e-13 49.2 0.0 6.9e-13 48.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 KOS17605.1 - 1.4e-05 24.8 0.0 2.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus AlaDh_PNT_C PF01262.21 KOS17605.1 - 0.031 13.6 0.3 0.39 10.0 0.1 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain PrpR_N PF06506.11 KOS17605.1 - 0.046 13.3 0.2 0.17 11.4 0.0 2.0 2 0 0 2 2 2 0 Propionate catabolism activator XdhC_C PF13478.6 KOS17605.1 - 0.051 14.1 0.3 1.4 9.4 0.1 2.8 3 0 0 3 3 3 0 XdhC Rossmann domain 2-Hacid_dh_C PF02826.19 KOS17605.1 - 0.074 12.4 0.0 0.17 11.3 0.0 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1297 PF06973.12 KOS17605.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1297) HI0933_like PF03486.14 KOS17605.1 - 0.14 10.8 0.1 0.26 9.9 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein ATP-grasp_4 PF13535.6 KOS17605.1 - 0.15 11.7 0.0 0.53 9.9 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain Yae1_N PF09811.9 KOS17606.1 - 3.6e-13 49.0 0.4 6.8e-13 48.1 0.4 1.5 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Romo1 PF10247.9 KOS17606.1 - 0.0016 18.8 0.0 0.0028 18.0 0.0 1.3 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 p450 PF00067.22 KOS17608.1 - 1.4e-46 159.3 0.0 5.3e-36 124.3 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 GTP_EFTU PF00009.27 KOS17610.1 - 2.5e-42 144.6 0.0 4e-42 144.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOS17610.1 - 5e-42 142.7 0.0 1e-41 141.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOS17610.1 - 2e-14 53.7 0.5 5.4e-14 52.3 0.5 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 KOS17610.1 - 0.036 14.0 0.4 0.098 12.6 0.4 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 KOS17610.1 - 0.039 14.0 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase MFS_1 PF07690.16 KOS17611.1 - 8.4e-44 149.9 22.8 1e-39 136.5 10.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS17611.1 - 2.6e-13 49.7 1.2 4.4e-13 48.9 1.2 1.3 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOS17611.1 - 2.9e-05 23.1 0.0 0.00014 20.8 0.0 2.2 2 1 0 2 2 2 1 MFS_1 like family MFS_5 PF05631.14 KOS17611.1 - 0.00011 21.3 0.1 0.00011 21.3 0.1 2.0 2 0 0 2 2 2 1 Sugar-tranasporters, 12 TM TRI12 PF06609.13 KOS17611.1 - 0.0099 14.3 1.8 0.017 13.6 1.8 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Connexin PF00029.19 KOS17611.1 - 0.013 15.3 0.3 0.022 14.5 0.3 1.3 1 0 0 1 1 1 0 Connexin FPN1 PF06963.12 KOS17611.1 - 0.16 10.5 5.3 1.5 7.3 0.1 3.0 1 1 2 3 3 3 0 Ferroportin1 (FPN1) OATP PF03137.20 KOS17611.1 - 1.1 7.4 4.5 19 3.4 4.4 2.2 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2722 PF10846.8 KOS17611.1 - 1.6 7.6 7.3 2.1 7.2 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) MAGE PF01454.19 KOS17612.1 - 1.2e-62 211.4 0.1 1.6e-62 211.0 0.1 1.2 1 0 0 1 1 1 1 MAGE family SLS PF14611.6 KOS17613.1 - 1.2e-33 116.9 0.1 1.6e-33 116.4 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Longin PF13774.6 KOS17614.1 - 2.2e-14 53.3 0.0 4.1e-14 52.4 0.0 1.5 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 KOS17614.1 - 3.4e-14 52.4 0.5 5.3e-14 51.8 0.5 1.2 1 0 0 1 1 1 1 Synaptobrevin Ras PF00071.22 KOS17616.1 - 1.2e-41 142.0 0.0 6.1e-41 139.7 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOS17616.1 - 5.7e-32 110.5 0.0 8e-32 110.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS17616.1 - 1.8e-10 40.6 0.0 2.9e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS17616.1 - 0.00023 21.2 0.0 0.00041 20.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 KOS17616.1 - 0.0021 18.5 0.0 0.0041 17.5 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 KOS17616.1 - 0.022 14.2 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DLIC PF05783.11 KOS17616.1 - 0.027 13.3 0.0 0.042 12.7 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_33 PF13671.6 KOS17616.1 - 0.029 14.5 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOS17616.1 - 0.047 13.7 0.0 0.086 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sec63 PF02889.16 KOS17617.1 - 1.1e-130 434.4 0.0 2.3e-80 269.4 0.7 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOS17617.1 - 1.2e-51 175.0 0.5 5.7e-26 91.3 0.3 3.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 KOS17617.1 - 1.7e-21 76.9 0.0 3e-10 40.4 0.0 2.6 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOS17617.1 - 7.5e-17 61.7 0.2 2.1e-06 28.1 0.0 4.7 3 2 0 3 3 3 2 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOS17617.1 - 1.6e-06 28.4 0.9 0.091 13.0 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_19 PF13245.6 KOS17617.1 - 1.3e-05 25.6 0.6 0.002 18.5 0.5 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOS17617.1 - 0.0021 18.5 0.2 1.2 9.5 0.0 3.6 2 2 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KOS17617.1 - 0.032 13.3 0.0 0.99 8.4 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Helicase_PWI PF18149.1 KOS17617.1 - 0.047 13.9 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 N-terminal helicase PWI domain IstB_IS21 PF01695.17 KOS17617.1 - 0.16 11.7 0.2 25 4.5 0.0 3.9 5 0 0 5 5 5 0 IstB-like ATP binding protein YL1_C PF08265.11 KOS17618.1 - 2.3e-14 52.8 0.1 3.8e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain DASH_Dad4 PF08650.10 KOS17619.1 - 1.8e-33 114.3 7.7 1.9e-33 114.2 7.7 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 GM_CSF PF01109.17 KOS17619.1 - 0.018 15.2 0.7 0.02 15.0 0.7 1.1 1 0 0 1 1 1 0 Granulocyte-macrophage colony-stimulating factor Profilin PF00235.19 KOS17620.1 - 1.3e-42 145.1 0.7 1.4e-42 144.9 0.7 1.0 1 0 0 1 1 1 1 Profilin Got1 PF04178.12 KOS17621.1 - 6.7e-14 52.3 12.3 8.6e-14 51.9 12.3 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family YrhK PF14145.6 KOS17621.1 - 0.028 14.3 12.5 0.06 13.2 5.1 2.8 2 1 1 3 3 3 0 YrhK-like protein DUF2206 PF09971.9 KOS17621.1 - 1.8 7.3 4.1 2.1 7.0 4.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) SdpI PF13630.6 KOS17621.1 - 8.6 6.6 10.1 7.4 6.8 2.2 2.3 2 0 0 2 2 2 0 SdpI/YhfL protein family Y_phosphatase PF00102.27 KOS17622.1 - 0.15 11.6 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF4620 PF15399.6 KOS17622.1 - 1.4 9.3 4.2 24 5.3 1.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4620) SUR7 PF06687.12 KOS17623.1 - 1.6e-17 63.9 0.9 2e-17 63.6 0.9 1.0 1 0 0 1 1 1 1 SUR7/PalI family Fig1 PF12351.8 KOS17623.1 - 0.066 13.1 8.3 0.11 12.4 5.9 2.1 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Biotin_lipoyl PF00364.22 KOS17624.1 - 9.6e-20 70.2 0.6 2.3e-19 69.0 0.6 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOS17624.1 - 6.2e-09 36.1 0.3 1.8e-08 34.6 0.3 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl_2 PF13533.6 KOS17624.1 - 0.00025 20.8 0.0 0.0044 16.8 0.0 2.8 3 0 0 3 3 3 1 Biotin-lipoyl like HlyD_3 PF13437.6 KOS17624.1 - 0.044 14.5 0.1 0.23 12.2 0.0 2.1 1 1 1 2 2 2 0 HlyD family secretion protein DUF2981 PF11200.8 KOS17624.1 - 0.14 11.9 0.2 0.22 11.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) RAP1 PF07218.11 KOS17624.1 - 2.5 6.3 4.6 3.3 5.9 4.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Evr1_Alr PF04777.13 KOS17625.1 - 2.7e-30 104.8 0.1 1.5e-29 102.4 0.0 1.9 2 0 0 2 2 2 1 Erv1 / Alr family TPP_enzyme_N PF02776.18 KOS17626.1 - 1.7e-28 99.4 0.0 3.2e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOS17626.1 - 4.8e-18 65.2 0.0 9.5e-18 64.3 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 KOS17626.1 - 5.2e-14 52.3 0.0 1.5e-13 50.8 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain SGT1 PF07093.11 KOS17627.1 - 3.2e-92 309.9 14.5 6.3e-83 279.2 0.0 2.0 1 1 1 2 2 2 2 SGT1 protein SMC_N PF02463.19 KOS17628.1 - 1.7e-19 70.1 10.6 2.9e-18 66.1 10.6 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KOS17628.1 - 2.9e-11 43.7 6.3 2.9e-11 43.7 6.3 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 KOS17628.1 - 1.2e-09 39.0 36.4 1.2e-09 39.0 36.4 6.1 3 2 0 3 3 3 1 AAA domain SMC_hinge PF06470.13 KOS17628.1 - 5.7e-05 23.4 0.1 0.0011 19.2 0.0 2.8 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOS17628.1 - 0.00081 19.3 10.0 0.0011 18.8 0.1 3.5 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOS17628.1 - 0.0019 17.9 0.0 0.0044 16.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 KOS17628.1 - 0.018 15.3 0.0 0.053 13.7 0.0 1.8 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit THUMP PF02926.17 KOS17630.1 - 4.9e-12 46.2 0.6 6.6e-11 42.5 0.6 2.0 1 1 0 1 1 1 1 THUMP domain SRP14 PF02290.15 KOS17631.1 - 6e-26 90.7 0.0 1.4e-25 89.5 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle 14kD protein MIF4G PF02854.19 KOS17632.1 - 2.3e-17 63.3 0.0 4.3e-17 62.5 0.0 1.5 1 0 0 1 1 1 1 MIF4G domain MA3 PF02847.17 KOS17632.1 - 1e-09 38.3 0.0 1.4e-08 34.7 0.0 2.8 2 2 0 2 2 2 1 MA3 domain Mpp10 PF04006.12 KOS17632.1 - 1.8 6.9 56.0 0.066 11.6 47.1 2.1 2 0 0 2 2 2 0 Mpp10 protein COQ9 PF08511.11 KOS17633.1 - 4.3e-28 96.9 0.0 7.7e-28 96.1 0.0 1.4 1 0 0 1 1 1 1 COQ9 RRM_1 PF00076.22 KOS17634.1 - 1.3e-35 121.0 0.0 7.7e-17 60.9 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ATP-grasp_2 PF08442.10 KOS17634.1 - 0.0013 18.3 0.0 0.02 14.5 0.0 2.3 2 0 0 2 2 2 1 ATP-grasp domain Limkain-b1 PF11608.8 KOS17634.1 - 0.0077 16.3 0.1 2.4 8.3 0.0 3.2 2 2 0 2 2 2 1 Limkain b1 RRM_occluded PF16842.5 KOS17634.1 - 0.016 15.1 0.0 6.8 6.6 0.0 2.3 2 0 0 2 2 2 0 Occluded RNA-recognition motif RRM_3 PF08777.11 KOS17634.1 - 0.061 13.4 0.0 2.8 8.0 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif RRM_Rrp7 PF17799.1 KOS17634.1 - 0.23 11.2 0.0 13 5.6 0.0 2.2 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain HSP70 PF00012.20 KOS17635.1 - 2e-74 250.9 2.7 2.6e-74 250.5 2.7 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS17635.1 - 1.6e-06 27.2 0.5 3.4e-06 26.1 0.5 1.6 1 1 0 1 1 1 1 MreB/Mbl protein Cwf_Cwc_15 PF04889.12 KOS17635.1 - 0.0061 16.3 4.6 0.013 15.2 4.6 1.6 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SPT2 PF08243.11 KOS17635.1 - 0.011 16.3 6.4 0.011 16.3 6.4 1.8 2 0 0 2 2 2 0 SPT2 chromatin protein CENP-B_dimeris PF09026.10 KOS17635.1 - 0.016 15.6 6.8 0.016 15.6 6.8 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 KOS17635.1 - 0.05 13.3 4.0 0.32 10.6 1.8 2.3 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 KOS17635.1 - 0.24 11.4 3.3 0.69 9.9 3.3 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 KOS17635.1 - 0.66 9.2 11.7 1.2 8.4 11.7 1.3 1 0 0 1 1 1 0 NOA36 protein GCIP PF13324.6 KOS17635.1 - 0.88 9.1 3.1 3.9 7.0 3.6 1.8 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 KOS17635.1 - 1 9.7 12.2 2.8 8.4 12.2 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 KOS17635.1 - 1.9 7.6 15.1 3.7 6.6 15.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4611 PF15387.6 KOS17635.1 - 5 7.4 10.7 0.56 10.5 4.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 KOS17635.1 - 5.7 4.9 12.1 9.6 4.2 12.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 KOS17635.1 - 5.7 5.3 6.0 20 3.6 5.2 1.9 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 KOS17635.1 - 6.4 6.3 9.1 0.47 10.0 3.9 1.7 2 0 0 2 2 2 0 PPP4R2 Rrp40_N PF18311.1 KOS17636.1 - 1.2e-16 60.3 0.7 6.3e-16 58.1 0.9 2.0 2 0 0 2 2 2 1 Exosome complex exonuclease Rrp40 N-terminal domain KH_6 PF15985.5 KOS17636.1 - 1.8e-13 50.6 0.1 4.6e-13 49.3 0.0 1.8 2 0 0 2 2 2 1 KH domain zf-C2H2 PF00096.26 KOS17637.1 - 6.1e-06 26.4 33.5 0.001 19.4 1.7 4.9 5 0 0 5 5 5 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS17637.1 - 0.022 15.6 1.0 0.022 15.6 1.0 4.8 5 1 0 5 5 5 0 C2H2-type zinc finger zf-Di19 PF05605.12 KOS17637.1 - 0.029 14.7 1.0 0.029 14.7 1.0 2.0 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Adeno_E3_CR2 PF02439.15 KOS17637.1 - 0.03 14.1 0.2 0.053 13.3 0.2 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Syndecan PF01034.20 KOS17637.1 - 0.12 12.3 0.1 0.31 11.0 0.0 1.7 2 0 0 2 2 2 0 Syndecan domain Sox17_18_mid PF12067.8 KOS17637.1 - 0.13 12.3 2.8 0.2 11.7 1.1 2.2 2 0 0 2 2 2 0 Sox 17/18 central domain DUF3487 PF11990.8 KOS17637.1 - 0.18 11.7 0.2 0.41 10.5 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Sina PF03145.16 KOS17637.1 - 0.5 10.3 13.3 1.6 8.7 9.8 2.3 1 1 1 2 2 2 0 Seven in absentia protein family FOXP-CC PF16159.5 KOS17637.1 - 0.99 10.1 11.4 0.96 10.1 0.7 2.7 2 1 1 3 3 3 0 FOXP coiled-coil domain zf-C2H2_aberr PF17017.5 KOS17637.1 - 1.3 9.2 4.4 0.33 11.1 0.4 1.8 2 0 0 2 2 2 0 Aberrant zinc-finger SAPS PF04499.15 KOS17638.1 - 0.072 11.9 2.0 0.081 11.7 2.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GAF PF01590.26 KOS17638.1 - 0.19 12.4 0.0 0.37 11.4 0.0 1.4 1 0 0 1 1 1 0 GAF domain SOG2 PF10428.9 KOS17638.1 - 0.22 10.7 10.2 0.25 10.5 10.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Dicty_REP PF05086.12 KOS17638.1 - 2.6 5.9 13.9 3.2 5.6 13.9 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Apt1 PF10351.9 KOS17638.1 - 4.4 6.0 14.2 5.8 5.7 14.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SpoIIIAH PF12685.7 KOS17638.1 - 8.7 6.1 15.2 18 5.1 15.2 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein EAF PF09816.9 KOS17639.1 - 3.1e-21 75.7 0.0 3.1e-21 75.7 0.0 2.7 3 0 0 3 3 3 1 RNA polymerase II transcription elongation factor Chorion_2 PF03964.15 KOS17639.1 - 0.0077 17.0 0.7 0.0077 17.0 0.7 3.0 2 1 0 2 2 2 1 Chorion family 2 FAM176 PF14851.6 KOS17639.1 - 0.0089 15.7 6.3 0.0089 15.7 6.3 3.3 2 1 2 4 4 4 1 FAM176 family CDC27 PF09507.10 KOS17639.1 - 1.5 8.1 39.3 0.38 10.1 36.5 1.4 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 LAT PF15234.6 KOS17639.1 - 1.5 8.5 21.5 0.098 12.4 11.9 2.4 2 0 0 2 2 2 0 Linker for activation of T-cells SSP160 PF06933.11 KOS17639.1 - 2.2 6.4 16.8 3.1 5.9 16.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 KOS17639.1 - 4.1 7.4 34.8 0.32 11.0 29.0 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein POP1 PF06978.11 KOS17640.1 - 1.2e-71 240.9 13.3 1.9e-71 240.3 13.3 1.3 1 0 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 KOS17640.1 - 6.6e-29 100.1 0.0 1.9e-28 98.6 0.0 1.8 1 0 0 1 1 1 1 POPLD (NUC188) domain NT-C2 PF10358.9 KOS17641.1 - 8.8e-25 87.1 0.0 1.9e-20 73.1 0.0 2.3 2 0 0 2 2 2 2 N-terminal C2 in EEIG1 and EHBP1 proteins TDA11 PF17084.5 KOS17641.1 - 1.3 7.9 12.0 3.1 6.7 11.8 1.6 1 1 0 1 1 1 0 Topoisomerase I damage affected protein 11 Ribosomal_S28e PF01200.18 KOS17642.1 - 3.5e-30 103.8 2.5 4e-30 103.6 2.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S28e IBR PF01485.21 KOS17643.1 - 6.1e-10 39.2 28.7 9.3e-06 25.8 6.3 3.7 3 0 0 3 3 3 3 IBR domain, a half RING-finger domain Pterin_4a PF01329.19 KOS17644.1 - 4.3e-24 84.5 0.2 8.7e-24 83.5 0.0 1.6 2 0 0 2 2 2 1 Pterin 4 alpha carbinolamine dehydratase HK PF02110.15 KOS17645.1 - 9.3e-75 251.2 2.8 9.3e-75 251.2 2.8 1.5 2 0 0 2 2 2 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 KOS17645.1 - 1.8e-57 193.6 0.8 3.7e-57 192.6 0.8 1.6 1 0 0 1 1 1 1 Thiamine monophosphate synthase Carb_kinase PF01256.17 KOS17645.1 - 8.7e-07 28.7 1.7 2.2e-06 27.3 0.2 2.1 1 1 0 2 2 2 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 KOS17645.1 - 2.3e-05 23.9 0.1 4.1e-05 23.1 0.1 1.3 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Peripla_BP_6 PF13458.6 KOS17645.1 - 0.017 14.8 0.9 0.3 10.7 0.1 2.6 2 1 1 3 3 3 0 Periplasmic binding protein Zn_clus PF00172.18 KOS17646.1 - 0.06 13.5 6.6 0.1 12.7 6.6 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain STE3 PF02076.15 KOS17647.1 - 2.6e-62 210.7 11.2 3.2e-62 210.4 11.2 1.1 1 0 0 1 1 1 1 Pheromone A receptor 7tm_1 PF00001.21 KOS17647.1 - 0.021 14.2 7.6 0.037 13.3 7.6 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4203 PF13886.6 KOS17648.1 - 4.7e-42 143.9 23.3 6e-42 143.6 23.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) DUF4570 PF15134.6 KOS17648.1 - 0.14 12.2 5.0 0.41 10.7 5.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) GSH_synth_ATP PF03917.17 KOS17649.1 - 2.3e-137 457.8 0.0 2.7e-137 457.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 KOS17649.1 - 1.6e-31 108.8 0.0 3.4e-31 107.7 0.0 1.6 1 0 0 1 1 1 1 Eukaryotic glutathione synthase SSB PF00436.25 KOS17650.1 - 9.2e-18 64.2 0.0 1.1e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family PilX PF13681.6 KOS17650.1 - 0.054 13.9 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 Type IV pilus assembly protein PilX C-term BP28CT PF08146.12 KOS17651.1 - 1e-38 132.6 0.0 7e-38 130.0 0.0 2.5 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 KOS17651.1 - 8.1e-26 90.6 0.4 8.1e-26 90.6 0.4 6.9 7 1 1 8 8 8 1 U3 small nucleolar RNA-associated protein 10 HEAT PF02985.22 KOS17651.1 - 2.8e-06 27.1 6.9 0.054 13.8 0.2 5.4 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 KOS17651.1 - 0.0038 17.6 20.1 0.39 11.1 0.4 6.6 6 0 0 6 6 6 2 HEAT repeats RTP1_C1 PF10363.9 KOS17651.1 - 0.041 14.1 3.2 2.9 8.1 0.0 4.6 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Ribosomal_S26e PF01283.19 KOS17652.1 - 5e-48 162.0 6.2 5e-48 162.0 6.2 1.6 2 0 0 2 2 2 1 Ribosomal protein S26e zf_CopZ PF18423.1 KOS17652.1 - 0.038 13.9 0.4 0.091 12.7 0.0 1.8 2 0 0 2 2 2 0 Zinc binding domain DUF4668 PF15701.5 KOS17652.1 - 0.25 11.1 5.6 1.6 8.6 5.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4668) SMC_N PF02463.19 KOS17653.1 - 9.5e-76 254.1 8.6 5.3e-38 130.7 1.5 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOS17653.1 - 1.3e-23 83.5 0.1 5.9e-23 81.4 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOS17653.1 - 3.1e-12 46.9 0.0 5.3e-05 23.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system IFT57 PF10498.9 KOS17653.1 - 0.00056 19.0 9.7 0.00056 19.0 9.7 5.7 3 2 2 5 5 5 2 Intra-flagellar transport protein 57 AAA_29 PF13555.6 KOS17653.1 - 0.00063 19.4 0.0 0.0013 18.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Tropomyosin_1 PF12718.7 KOS17653.1 - 0.0011 19.1 10.0 0.0011 19.1 10.0 7.7 3 2 4 8 8 8 2 Tropomyosin like ATG16 PF08614.11 KOS17653.1 - 0.0072 16.6 11.0 0.0072 16.6 11.0 9.2 4 2 3 8 8 8 2 Autophagy protein 16 (ATG16) SbcCD_C PF13558.6 KOS17653.1 - 0.067 13.4 0.0 0.72 10.1 0.0 2.5 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Spc7 PF08317.11 KOS17653.1 - 0.64 8.8 122.2 0.13 11.1 23.3 7.5 3 2 5 8 8 8 0 Spc7 kinetochore protein ABC_tran PF00005.27 KOS17653.1 - 1.7 9.1 0.0 1.7 9.1 0.0 5.8 4 2 0 4 4 4 0 ABC transporter IPK PF03770.16 KOS17655.1 - 1.8e-54 184.6 0.0 2.7e-54 184.0 0.0 1.3 1 0 0 1 1 1 1 Inositol polyphosphate kinase XPA_C PF05181.12 KOS17656.1 - 1.3e-25 89.1 2.2 2.5e-25 88.2 2.2 1.5 1 0 0 1 1 1 1 XPA protein C-terminus FRG1 PF06229.12 KOS17656.1 - 0.019 14.7 0.5 0.049 13.3 0.5 1.7 1 0 0 1 1 1 0 FRG1-like domain XPA_N PF01286.18 KOS17656.1 - 0.15 12.1 9.3 0.096 12.7 3.4 2.5 2 0 0 2 2 2 0 XPA protein N-terminal zf-C3HC4_3 PF13920.6 KOS17656.1 - 0.68 9.8 6.8 0.35 10.8 4.0 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PGBA_C PF15437.6 KOS17656.1 - 3 8.3 14.6 0.2 12.0 2.7 2.5 2 0 0 2 2 2 0 Plasminogen-binding protein pgbA C-terminal ArfGap PF01412.18 KOS17656.1 - 5.2 7.2 8.1 0.27 11.3 1.5 2.2 3 0 0 3 3 3 0 Putative GTPase activating protein for Arf Pkinase PF00069.25 KOS17657.1 - 1.7e-49 168.6 0.0 2.3e-33 115.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17657.1 - 8.7e-22 77.6 0.1 8.7e-20 71.1 0.1 3.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17657.1 - 0.00013 21.4 0.0 0.00032 20.1 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 KOS17657.1 - 0.0028 17.6 1.1 0.018 15.0 0.1 2.8 2 1 1 3 3 3 1 Phosphotransferase enzyme family Glycos_transf_1 PF00534.20 KOS17658.1 - 3.6e-28 98.2 0.0 4.5e-16 58.9 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOS17658.1 - 2e-16 60.4 0.6 2e-16 60.4 0.6 1.6 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 KOS17658.1 - 8.4e-14 52.1 0.0 4.7e-12 46.5 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOS17658.1 - 7.1e-10 39.5 5.7 7.1e-10 39.5 5.7 2.3 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain ALG11_N PF15924.5 KOS17658.1 - 0.02 14.9 0.1 8.7 6.3 0.0 2.7 1 1 1 2 2 2 0 ALG11 mannosyltransferase N-terminus Glyco_trans_1_2 PF13524.6 KOS17658.1 - 0.11 12.9 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 ECH_1 PF00378.20 KOS17659.1 - 2.9e-19 69.4 0.0 3.5e-19 69.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS17659.1 - 7.1e-08 32.3 0.0 1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 KOS17659.1 - 0.057 13.4 0.2 12 5.9 0.1 2.4 2 1 0 2 2 2 0 Peptidase family S49 RabGAP-TBC PF00566.18 KOS17660.1 - 4.5e-44 150.7 0.0 7.3e-44 150.0 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_4 PF12799.7 KOS17661.1 - 1.6e-32 110.9 27.5 5.8e-06 26.6 3.3 9.1 7 1 3 10 10 10 8 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS17661.1 - 1.4e-23 82.4 32.5 1.3e-06 28.1 1.6 8.1 8 1 0 8 8 8 4 Leucine rich repeat LRR_9 PF14580.6 KOS17661.1 - 2.9e-10 39.9 8.8 0.015 14.8 0.3 4.6 1 1 4 5 5 5 3 Leucine-rich repeat LRR_6 PF13516.6 KOS17661.1 - 1.5e-09 37.1 8.2 2.7 8.3 0.1 8.6 7 0 0 7 7 7 2 Leucine Rich repeat LRR_1 PF00560.33 KOS17661.1 - 0.00021 21.4 24.4 9.6 7.2 0.0 10.7 11 1 1 12 12 9 1 Leucine Rich Repeat Ntox33 PF15533.6 KOS17661.1 - 0.16 12.5 0.2 0.42 11.1 0.2 1.7 1 0 0 1 1 1 0 Bacterial toxin 33 DUF4611 PF15387.6 KOS17661.1 - 0.2 11.9 6.7 0.59 10.4 5.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Nop14 PF04147.12 KOS17661.1 - 0.42 8.8 7.6 0.59 8.3 7.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KOS17661.1 - 0.69 8.1 4.1 1.1 7.5 4.1 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 KOS17661.1 - 2.1 6.3 15.1 3.1 5.8 15.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi GCIP PF13324.6 KOS17661.1 - 2.9 7.4 4.3 6.2 6.3 4.3 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting SDA1 PF05285.12 KOS17661.1 - 4 6.8 8.8 6.9 6.0 8.8 1.3 1 0 0 1 1 1 0 SDA1 YL1 PF05764.13 KOS17661.1 - 4 7.5 10.8 7.8 6.5 10.8 1.4 1 0 0 1 1 1 0 YL1 nuclear protein CorA PF01544.18 KOS17665.1 - 3.1e-13 49.7 0.0 4.5e-13 49.2 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF5316 PF17247.2 KOS17667.1 - 0.043 13.8 2.1 0.043 13.8 2.1 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5316) Psm4 PF17063.5 KOS17667.1 - 0.68 10.6 4.1 0.66 10.7 2.4 1.8 2 0 0 2 2 2 0 Phenol-soluble modulin alpha 4 peptide Tagatose_6_P_K PF08013.11 KOS17669.1 - 0.26 9.9 0.0 0.32 9.6 0.0 1.0 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase Rpr2 PF04032.16 KOS17670.1 - 2.8e-25 88.4 0.3 4.1e-25 87.9 0.3 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-CGNR PF11706.8 KOS17670.1 - 0.026 14.4 1.9 0.071 13.0 1.9 1.8 1 0 0 1 1 1 0 CGNR zinc finger Cyclin PF08613.11 KOS17671.1 - 2.6e-08 34.4 0.1 6e-08 33.2 0.1 1.7 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOS17671.1 - 0.00083 19.1 0.0 0.0019 17.9 0.0 1.7 1 0 0 1 1 1 1 Cyclin, N-terminal domain DEAD PF00270.29 KOS17672.1 - 2.2e-35 122.0 0.0 4.1e-35 121.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17672.1 - 2e-25 89.3 0.1 8.9e-24 84.0 0.1 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17672.1 - 2e-08 34.5 0.0 4.6e-08 33.3 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF4844 PF16133.5 KOS17672.1 - 0.018 15.6 0.4 0.051 14.1 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4844) ERCC4 PF02732.15 KOS17674.1 - 8.1e-19 68.4 0.0 2.1e-18 67.0 0.0 1.7 2 0 0 2 2 2 1 ERCC4 domain ASF1_hist_chap PF04729.13 KOS17675.1 - 1.5e-71 239.3 0.0 2.1e-71 238.8 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone Nop14 PF04147.12 KOS17675.1 - 3.5 5.7 21.7 4.5 5.4 21.7 1.0 1 0 0 1 1 1 0 Nop14-like family RasGAP PF00616.19 KOS17676.1 - 9.7e-58 195.3 0.1 5.3e-57 192.9 0.0 2.1 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 KOS17676.1 - 1.5e-29 102.9 4.7 1.5e-29 102.9 4.7 2.4 2 0 0 2 2 2 1 RasGAP C-terminus FlxA PF14282.6 KOS17676.1 - 0.39 10.7 5.7 7.1 6.7 1.1 2.8 2 0 0 2 2 2 0 FlxA-like protein Suf PF05843.14 KOS17678.1 - 1.6e-80 271.3 0.9 1.3e-75 255.2 0.0 4.6 4 1 0 4 4 4 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 KOS17678.1 - 0.00024 21.7 0.1 0.038 14.8 0.1 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat Lgl_C PF08596.10 KOS17679.1 - 2.2e-114 382.2 0.0 3.5e-114 381.6 0.0 1.3 1 0 0 1 1 1 1 Lethal giant larvae(Lgl) like, C-terminal WD40 PF00400.32 KOS17679.1 - 9.2e-06 26.3 2.7 0.01 16.7 0.1 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17679.1 - 0.001 19.3 0.0 0.47 10.8 0.0 4.2 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain ArgoL1 PF08699.10 KOS17680.1 - 4.9e-15 54.9 0.2 1.7e-14 53.2 0.0 2.0 2 0 0 2 2 2 1 Argonaute linker 1 domain PAZ PF02170.22 KOS17680.1 - 1.9e-12 47.1 0.0 3.1e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 PAZ domain ArgoL2 PF16488.5 KOS17680.1 - 2.7e-12 46.8 0.0 5e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Argonaute linker 2 domain ArgoMid PF16487.5 KOS17680.1 - 0.00011 22.4 0.2 0.00026 21.2 0.2 1.6 1 0 0 1 1 1 1 Mid domain of argonaute CLP1_P PF16575.5 KOS17681.1 - 1.4e-29 103.3 0.0 2e-29 102.7 0.0 1.3 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_33 PF13671.6 KOS17681.1 - 0.056 13.6 0.0 0.27 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOS17681.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain Redoxin PF08534.10 KOS17683.1 - 1.8e-24 86.1 0.0 2.2e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOS17683.1 - 0.0091 15.9 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family DUF2938 PF11158.8 KOS17683.1 - 0.18 11.3 0.0 0.81 9.2 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2938) IBR PF01485.21 KOS17684.1 - 1.3e-21 76.5 46.6 1.8e-12 47.3 4.8 4.5 3 1 1 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 KOS17684.1 - 6.1e-05 22.8 5.0 6.1e-05 22.8 5.0 4.5 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS17684.1 - 0.00068 19.9 7.2 0.00068 19.9 7.2 4.3 2 1 1 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOS17684.1 - 0.0051 16.6 5.4 0.0051 16.6 5.4 5.0 3 1 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS17684.1 - 0.012 15.6 4.7 0.012 15.6 4.7 3.8 3 1 0 3 3 3 0 RING-type zinc-finger zf-RING_4 PF14570.6 KOS17684.1 - 0.05 13.4 36.5 0.44 10.4 9.9 4.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain CobA_CobO_BtuR PF02572.15 KOS17684.1 - 0.12 12.7 1.1 2.6 8.3 0.6 2.4 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP zf-RING_14 PF17978.1 KOS17684.1 - 9.7 6.7 12.1 0.17 12.4 2.4 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain ECM11 PF15463.6 KOS17685.1 - 1.5e-43 148.6 0.8 1.8e-43 148.3 0.8 1.1 1 0 0 1 1 1 1 Extracellular mutant protein 11 DnaG_DnaB_bind PF08278.11 KOS17685.1 - 0.013 16.1 0.1 0.018 15.7 0.1 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding ADH_zinc_N PF00107.26 KOS17686.1 - 6.9e-21 74.6 1.7 1.1e-15 57.8 0.0 2.3 2 0 0 2 2 2 2 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS17686.1 - 2.8e-13 51.1 0.0 6.8e-13 49.8 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOS17686.1 - 2.4e-05 24.2 0.0 0.00018 21.3 0.0 2.4 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain NOA36 PF06524.12 KOS17686.1 - 0.13 11.6 10.9 0.23 10.8 10.9 1.4 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 KOS17686.1 - 7.5 4.6 12.0 12 4.0 12.0 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KOS17686.1 - 9.7 5.5 11.8 14 5.0 11.8 1.1 1 0 0 1 1 1 0 SDA1 Methyltransf_25 PF13649.6 KOS17688.1 - 0.097 13.4 0.0 0.16 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain HLH PF00010.26 KOS17689.1 - 1.2e-06 28.4 0.7 2.3e-06 27.4 0.1 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain tRNA-synt_2b PF00587.25 KOS17690.1 - 3.2e-33 115.2 0.0 4.5e-29 101.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOS17690.1 - 5e-07 29.8 0.0 1.1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain Bromodomain PF00439.25 KOS17691.1 - 2.4e-28 98.0 0.3 7.1e-14 51.6 0.1 2.4 2 0 0 2 2 2 2 Bromodomain BSP_II PF05432.11 KOS17691.1 - 5.6e-05 23.0 31.5 0.00013 21.8 31.5 1.6 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DUF2201_N PF13203.6 KOS17691.1 - 0.0067 16.1 0.3 0.029 14.0 0.3 2.0 1 1 0 1 1 1 1 Putative metallopeptidase domain BUD22 PF09073.10 KOS17691.1 - 0.0072 15.7 23.0 0.013 14.8 23.0 1.4 1 0 0 1 1 1 1 BUD22 Mpp10 PF04006.12 KOS17691.1 - 0.47 8.8 30.5 0.17 10.3 19.3 2.1 1 1 1 2 2 2 0 Mpp10 protein FancD2 PF14631.6 KOS17691.1 - 3.3 5.0 5.4 4.9 4.4 5.4 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Maf PF02545.14 KOS17692.1 - 6.9e-49 165.9 0.0 8e-49 165.7 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein rRNA_proc-arch PF13234.6 KOS17693.1 - 2.4e-88 296.6 0.1 2.2e-87 293.4 0.0 2.3 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 KOS17693.1 - 1.3e-50 171.3 1.8 3.2e-50 170.0 1.8 1.7 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 KOS17693.1 - 2.9e-19 69.5 0.0 2e-18 66.8 0.0 2.3 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17693.1 - 1.6e-06 28.4 0.1 6.4e-06 26.5 0.1 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17693.1 - 1.3e-05 25.2 0.0 4.6e-05 23.5 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 KOS17693.1 - 0.0059 15.7 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 KOS17693.1 - 0.032 14.5 0.0 0.15 12.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Prp19 PF08606.11 KOS17693.1 - 0.42 10.6 1.9 5.8 7.0 0.2 2.5 2 0 0 2 2 2 0 Prp19/Pso4-like Herpes_LMP1 PF05297.11 KOS17693.1 - 4.4 6.4 6.7 8.6 5.4 6.7 1.4 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) CDC45 PF02724.14 KOS17693.1 - 4.8 5.4 10.9 5.6 5.1 9.2 1.8 2 0 0 2 2 2 0 CDC45-like protein DUF2407_C PF13373.6 KOS17694.1 - 4.2e-33 114.5 0.0 6e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 KOS17694.1 - 2.8e-26 92.1 0.0 4.1e-26 91.6 0.0 1.2 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Mito_fiss_reg PF05308.11 KOS17694.1 - 0.0095 16.0 0.5 0.0095 16.0 0.5 2.6 2 1 1 3 3 3 1 Mitochondrial fission regulator ubiquitin PF00240.23 KOS17694.1 - 0.025 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family DUF3446 PF11928.8 KOS17694.1 - 0.041 14.2 3.4 0.041 14.2 3.4 2.0 2 0 0 2 2 2 0 Early growth response N-terminal domain PPR_2 PF13041.6 KOS17695.1 - 1.7e-17 63.3 0.9 0.00015 21.9 0.0 5.5 4 1 1 5 5 5 4 PPR repeat family PPR PF01535.20 KOS17695.1 - 3.3e-12 45.8 4.0 0.00066 19.7 0.0 5.9 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.6 KOS17695.1 - 1.3e-08 34.8 0.0 0.0046 17.0 0.0 4.1 4 0 0 4 4 4 2 Pentatricopeptide repeat domain PPR_long PF17177.4 KOS17695.1 - 0.005 16.2 0.2 0.035 13.5 0.0 2.1 1 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOS17695.1 - 0.097 12.4 5.8 21 4.9 0.1 4.5 4 0 0 4 4 4 0 PPR repeat COX7C PF02935.16 KOS17696.1 - 2.1e-24 85.6 2.1 2.5e-24 85.3 2.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc Aim19 PF10315.9 KOS17697.1 - 1.4e-05 25.3 1.1 0.00017 21.9 0.2 2.1 1 1 1 2 2 2 2 Altered inheritance of mitochondria protein 19 Zn_clus PF00172.18 KOS17698.1 - 1e-06 28.7 9.1 1.5e-06 28.2 9.1 1.2 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Gly-zipper_YMGG PF13441.6 KOS17698.1 - 0.16 11.7 10.7 0.31 10.8 10.7 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 KOS17698.1 - 8.2 6.5 12.5 29 4.8 12.4 1.9 1 1 0 1 1 1 0 Glycine zipper Ima1_N PF09779.9 KOS17699.1 - 1.7e-36 126.1 2.3 3.1e-36 125.2 2.3 1.5 1 0 0 1 1 1 1 Ima1 N-terminal domain DZR PF12773.7 KOS17699.1 - 0.018 15.1 2.3 2.3 8.3 0.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.11 KOS17699.1 - 0.93 9.5 5.1 0.2 11.6 1.5 1.7 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Y_phosphatase2 PF03162.13 KOS17700.1 - 7.9e-44 149.1 0.0 1.2e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 KOS17700.1 - 1.6e-09 38.1 0.0 9.9e-09 35.5 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 KOS17700.1 - 0.0076 16.1 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOS17700.1 - 0.012 15.2 0.0 0.019 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Phage_base_V PF04717.12 KOS17700.1 - 0.038 13.9 0.0 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 Type VI secretion system, phage-baseplate injector Pho88 PF10032.9 KOS17701.1 - 7.9e-83 276.2 0.3 9e-83 276.0 0.3 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) MOEP19 PF16005.5 KOS17701.1 - 0.15 12.0 0.0 0.44 10.6 0.0 1.7 1 0 0 1 1 1 0 KH-like RNA-binding domain DAO PF01266.24 KOS17702.1 - 8e-11 42.1 0.3 3.5e-09 36.7 0.2 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 KOS17702.1 - 0.0091 15.3 0.0 0.025 13.8 0.0 1.6 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS17702.1 - 0.051 12.8 0.0 0.074 12.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase CP12 PF02672.15 KOS17703.1 - 0.015 16.1 1.1 0.034 14.9 1.1 1.6 1 0 0 1 1 1 0 CP12 domain TPR_1 PF00515.28 KOS17704.1 - 0.055 13.3 7.5 3 7.8 0.4 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS17704.1 - 0.11 12.6 8.4 0.69 10.2 0.7 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Presenilin PF01080.17 KOS17704.1 - 1.3 7.7 2.1 1.8 7.2 2.1 1.2 1 0 0 1 1 1 0 Presenilin HIT PF01230.23 KOS17705.1 - 2.2e-19 70.0 0.0 3.5e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KOS17705.1 - 7e-05 23.3 0.0 0.00011 22.7 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 KOS17705.1 - 0.29 11.0 0.8 2.6 7.9 0.2 2.5 2 1 0 2 2 2 0 Protein similar to CwfJ C-terminus 1 G-alpha PF00503.20 KOS17706.1 - 3.2e-98 329.2 3.4 1.2e-81 274.7 0.7 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 KOS17706.1 - 1.1e-11 44.5 0.3 3.9e-10 39.5 0.2 2.5 2 1 0 2 2 2 1 ADP-ribosylation factor family DUF1287 PF06940.11 KOS17706.1 - 0.074 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) IGR PF09597.10 KOS17707.1 - 1e-24 86.4 0.1 1.6e-24 85.7 0.1 1.3 1 0 0 1 1 1 1 IGR protein motif DUF1593 PF07632.11 KOS17707.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) Mid1 PF12929.7 KOS17708.1 - 9e-141 469.9 0.1 1.1e-140 469.7 0.1 1.0 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 KOS17708.1 - 0.00024 21.7 4.7 0.071 13.7 1.1 2.4 2 0 0 2 2 2 2 Fz domain MFS_1 PF07690.16 KOS17709.1 - 2.3e-23 82.7 33.5 6.5e-23 81.2 33.5 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily Tail_VII PF17091.5 KOS17709.1 - 0.36 10.7 3.1 1.2 9.0 3.1 1.9 1 0 0 1 1 1 0 Inovirus G7P protein Glyco_hydro_92 PF07971.12 KOS17711.1 - 1.8e-142 475.5 0.0 2.2e-142 475.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOS17711.1 - 1.3e-64 218.3 0.1 2.4e-64 217.5 0.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain SLT PF01464.20 KOS17712.1 - 0.014 15.1 1.6 0.06 13.0 1.6 2.0 1 1 0 1 1 1 0 Transglycosylase SLT domain Lysozyme_like PF13702.6 KOS17712.1 - 0.11 12.2 2.4 0.19 11.5 2.4 1.5 1 1 0 1 1 1 0 Lysozyme-like NAD_binding_4 PF07993.12 KOS17713.1 - 3.3e-29 101.9 0.0 1.1e-28 100.2 0.0 1.8 2 0 0 2 2 2 1 Male sterility protein AMP-binding PF00501.28 KOS17713.1 - 2.1e-27 95.8 0.0 1.1e-26 93.4 0.0 1.9 1 1 0 1 1 1 1 AMP-binding enzyme Epimerase PF01370.21 KOS17713.1 - 1.1e-08 34.9 0.0 2e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOS17713.1 - 3.3e-05 23.1 0.0 0.00058 19.0 0.0 2.2 2 0 0 2 2 2 1 RmlD substrate binding domain PP-binding PF00550.25 KOS17713.1 - 8.7e-05 22.8 0.0 0.00027 21.2 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 KOS17713.1 - 0.031 13.3 0.0 0.085 11.9 0.0 1.7 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 KOS17713.1 - 0.087 12.7 0.1 0.39 10.6 0.1 2.1 2 0 0 2 2 2 0 KR domain Sugar_tr PF00083.24 KOS17714.1 - 8.2e-123 410.6 15.9 1.4e-122 409.8 15.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17714.1 - 1.5e-25 89.9 27.5 2.6e-19 69.4 8.9 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2721 PF11026.8 KOS17714.1 - 0.62 10.0 5.5 13 5.7 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) HEAT_2 PF13646.6 KOS17715.1 - 1.4e-25 89.5 9.2 3e-13 50.0 0.3 3.6 2 2 1 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 KOS17715.1 - 3.1e-19 67.6 11.1 0.023 15.4 0.2 6.6 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 KOS17715.1 - 6.6e-05 22.8 10.0 0.16 12.3 0.0 6.1 6 0 0 6 6 6 1 HEAT repeat HEAT_EZ PF13513.6 KOS17715.1 - 0.087 13.4 15.9 0.91 10.1 0.1 5.0 4 1 1 5 5 5 0 HEAT-like repeat Arm PF00514.23 KOS17715.1 - 0.31 11.1 4.3 10 6.3 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat DEP PF00610.21 KOS17716.1 - 2.4e-25 88.4 0.1 5.2e-25 87.3 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Cation_efflux PF01545.21 KOS17717.1 - 1.9e-12 47.3 3.3 2.4e-12 47.0 3.3 1.1 1 0 0 1 1 1 1 Cation efflux family UDPGT PF00201.18 KOS17718.1 - 0.014 14.3 0.0 0.028 13.2 0.0 1.4 2 0 0 2 2 2 0 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_transf_28 PF03033.20 KOS17718.1 - 0.031 14.3 0.1 0.031 14.3 0.1 1.7 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain Fungal_trans_2 PF11951.8 KOS17721.1 - 2e-37 128.9 0.0 2.8e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain AT_hook PF02178.19 KOS17721.1 - 0.052 13.4 5.1 0.17 11.9 5.1 1.9 1 0 0 1 1 1 0 AT hook motif HTH_30 PF13556.6 KOS17721.1 - 0.059 13.2 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF3915 PF13054.6 KOS17722.1 - 0.66 10.0 8.0 2.6 8.0 5.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) CDC45 PF02724.14 KOS17722.1 - 3.7 5.7 7.9 4.1 5.6 7.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 KOS17722.1 - 9.2 6.6 14.8 14 6.0 14.8 1.3 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA_16 PF13191.6 KOS17724.1 - 1.8e-07 31.7 0.0 4.7e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 KOS17724.1 - 2e-07 31.2 0.0 3.1e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_29 PF13555.6 KOS17724.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF815 PF05673.13 KOS17724.1 - 0.047 12.8 0.0 0.092 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DAP3 PF10236.9 KOS17724.1 - 0.055 12.6 0.2 1.6 7.8 0.0 2.7 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 KOS17724.1 - 0.1 12.1 0.1 0.67 9.5 0.1 2.3 1 1 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 KOS17725.1 - 5.4e-15 55.3 3.2 1e-09 38.4 0.1 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS17725.1 - 6.4e-15 55.1 2.4 2.1e-11 43.9 0.1 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain p450 PF00067.22 KOS17726.1 - 2e-18 66.4 0.0 3.5e-17 62.3 0.0 2.0 1 1 0 1 1 1 1 Cytochrome P450 ABC_membrane PF00664.23 KOS17727.1 - 1.3e-41 143.1 12.4 1.6e-41 142.8 12.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOS17727.1 - 5.2e-34 117.7 0.0 2.7e-33 115.4 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 KOS17727.1 - 3.1e-05 24.4 0.0 6.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain SMC_N PF02463.19 KOS17727.1 - 5e-05 22.8 0.0 0.0051 16.3 0.0 2.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOS17727.1 - 0.00056 19.8 0.0 0.022 14.6 0.0 2.3 1 1 1 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 KOS17727.1 - 0.0016 18.7 0.0 0.0082 16.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOS17727.1 - 0.0017 18.3 0.0 0.01 15.8 0.0 2.0 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 KOS17727.1 - 0.0027 17.8 0.0 0.022 14.9 0.0 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_14 PF13173.6 KOS17727.1 - 0.0075 16.3 0.0 0.039 14.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOS17727.1 - 0.0081 16.6 0.0 0.06 13.8 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 KOS17727.1 - 0.013 15.2 0.0 0.032 14.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 KOS17727.1 - 0.015 15.6 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 KOS17727.1 - 0.021 14.5 0.0 0.043 13.5 0.0 1.5 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.6 KOS17727.1 - 0.028 14.7 0.4 0.72 10.1 0.4 2.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.6 KOS17727.1 - 0.033 13.8 0.0 0.097 12.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 KOS17727.1 - 0.034 13.9 0.0 0.077 12.7 0.0 1.7 2 0 0 2 2 1 0 AAA domain Rad17 PF03215.15 KOS17727.1 - 0.034 14.1 0.0 0.074 13.0 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 KOS17727.1 - 0.063 13.8 0.0 0.27 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 KOS17727.1 - 0.072 13.3 0.0 0.19 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KOS17727.1 - 0.077 13.5 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOS17727.1 - 0.13 11.5 0.0 0.32 10.3 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_10 PF12846.7 KOS17727.1 - 0.13 11.1 0.0 0.28 10.1 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain NACHT PF05729.12 KOS17727.1 - 0.16 11.8 0.0 0.51 10.2 0.0 1.8 2 0 0 2 2 1 0 NACHT domain Erf4 PF10256.9 KOS17728.1 - 1.3e-35 122.0 0.0 1.7e-35 121.6 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family TRAP_alpha PF03896.16 KOS17729.1 - 0.25 10.5 1.5 0.44 9.7 1.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit BolA PF01722.18 KOS17730.1 - 1.5e-29 102.1 0.6 1.9e-29 101.7 0.6 1.2 1 0 0 1 1 1 1 BolA-like protein Ribosomal_L26 PF16906.5 KOS17730.1 - 0.1 13.1 0.7 0.29 11.6 0.1 1.9 2 0 0 2 2 2 0 Ribosomal proteins L26 eukaryotic, L24P archaeal AMP-binding PF00501.28 KOS17731.1 - 4e-66 223.4 0.0 3.4e-35 121.5 0.0 2.0 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 KOS17731.1 - 5.3e-13 49.8 0.0 1.1e-12 48.7 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PIP5K PF01504.18 KOS17732.1 - 5.1e-33 114.5 0.2 2.2e-24 86.1 0.3 2.5 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 KOS17732.1 - 2.6e-28 98.9 0.0 4.1e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 KOS17732.1 - 8.7e-15 54.6 7.0 8.7e-15 54.6 7.0 1.9 2 0 0 2 2 2 1 FYVE zinc finger C1_2 PF03107.16 KOS17732.1 - 0.59 10.5 7.7 0.27 11.6 4.2 2.1 2 0 0 2 2 2 0 C1 domain C1_1 PF00130.22 KOS17732.1 - 6.1 6.8 8.0 1.2 9.1 3.9 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HMGL-like PF00682.19 KOS17734.1 - 1.4e-78 264.1 1.1 2.2e-78 263.5 1.1 1.3 1 0 0 1 1 1 1 HMGL-like Trp_syntA PF00290.20 KOS17734.1 - 0.049 12.5 0.0 5.3 5.8 0.0 2.4 2 0 0 2 2 2 0 Tryptophan synthase alpha chain IF4E PF01652.18 KOS17736.1 - 4.1e-54 182.7 0.0 5.3e-54 182.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E UMP1 PF05348.11 KOS17738.1 - 2.3e-41 140.7 0.0 1.6e-40 138.0 0.0 2.0 1 1 0 1 1 1 1 Proteasome maturation factor UMP1 ABC_tran PF00005.27 KOS17739.1 - 2.4e-21 76.7 0.0 2.3e-10 41.1 0.0 3.3 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOS17739.1 - 1.1e-10 41.8 0.3 0.00044 20.2 0.1 3.4 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOS17739.1 - 1.2e-07 32.4 0.0 0.0044 17.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KOS17739.1 - 1.2e-05 24.9 0.0 0.19 11.5 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain SbcCD_C PF13558.6 KOS17739.1 - 2.1e-05 24.6 0.1 0.071 13.4 0.1 2.4 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.6 KOS17739.1 - 0.00029 21.1 0.0 1.3 9.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KOS17739.1 - 0.00046 20.6 0.3 0.74 10.2 0.0 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 KOS17739.1 - 0.0027 17.9 0.0 1.4 9.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS17739.1 - 0.0031 18.0 0.0 5.2 7.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOS17739.1 - 0.0039 17.4 0.1 2.1 8.6 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 KOS17739.1 - 0.0097 15.6 0.0 3.7 7.2 0.0 2.3 2 0 0 2 2 2 2 AAA domain Ploopntkinase1 PF18748.1 KOS17739.1 - 0.019 14.5 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 SMC_N PF02463.19 KOS17739.1 - 0.025 14.0 0.0 3.9 6.8 0.2 2.4 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain ATP_bind_1 PF03029.17 KOS17739.1 - 0.089 12.6 0.1 4.3 7.0 0.0 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 KOS17739.1 - 0.093 12.8 0.0 6.5 6.8 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOS17739.1 - 0.1 12.3 0.0 14 5.2 0.2 2.1 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 KOS17739.1 - 0.1 13.0 0.0 16 5.9 0.0 2.4 2 0 0 2 2 2 0 RNA helicase PduV-EutP PF10662.9 KOS17739.1 - 0.13 12.1 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 KOS17739.1 - 0.14 12.6 0.1 5 7.6 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Lactonase PF10282.9 KOS17740.1 - 5.1e-82 275.9 0.0 7.3e-82 275.4 0.0 1.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller PEMT PF04191.13 KOS17741.1 - 2e-58 195.3 8.3 7.2e-37 126.0 0.8 2.6 2 0 0 2 2 2 2 Phospholipid methyltransferase SKICH PF17751.1 KOS17741.1 - 0.038 14.5 0.0 2.5 8.7 0.0 2.5 2 0 0 2 2 2 0 SKICH domain HECW_N PF16562.5 KOS17741.1 - 0.056 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 Mucin PF01456.17 KOS17741.1 - 6.1 6.8 19.0 13 5.8 19.0 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein eIF3g PF12353.8 KOS17742.1 - 2.4e-44 150.7 2.1 4.2e-44 150.0 2.1 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 KOS17742.1 - 6.3e-15 54.8 0.1 1.3e-14 53.7 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_7 PF18586.1 KOS17742.1 - 0.038 14.3 0.2 0.074 13.4 0.2 1.4 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Ribosomal_60s PF00428.19 KOS17742.1 - 1.9 9.1 9.8 0.33 11.6 5.7 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF202 PF02656.15 KOS17744.1 - 2.9e-17 62.9 1.4 8.3e-16 58.2 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF202) T4SS_CagC PF16943.5 KOS17744.1 - 0.41 10.8 3.9 3.1 8.0 1.7 2.4 1 1 1 2 2 2 0 Cag pathogenicity island, type IV secretory system DUF676 PF05057.14 KOS17746.1 - 3.2e-41 141.2 0.0 1.6e-26 93.2 0.0 3.2 3 0 0 3 3 3 3 Putative serine esterase (DUF676) PGAP1 PF07819.13 KOS17746.1 - 0.13 11.9 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 PGAP1-like protein LRS4 PF10422.9 KOS17746.1 - 1 8.9 9.4 0.074 12.6 0.6 2.7 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 Nop25 PF09805.9 KOS17746.1 - 5.1 7.6 8.7 0.8 10.2 3.7 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Cwf_Cwc_15 PF04889.12 KOS17746.1 - 8.2 6.1 13.3 0.033 13.9 3.9 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 KOS17746.1 - 8.5 6.2 19.1 0.014 15.4 4.7 2.5 2 1 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ctr PF04145.15 KOS17749.1 - 3.4e-40 138.1 0.1 4.6e-40 137.6 0.1 1.2 1 0 0 1 1 1 1 Ctr copper transporter family YfhO PF09586.10 KOS17749.1 - 0.18 10.0 3.3 0.25 9.5 3.3 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO 2OG-FeII_Oxy_2 PF13532.6 KOS17750.1 - 0.012 15.8 0.0 2.7 8.1 0.0 2.1 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Ank_4 PF13637.6 KOS17751.1 - 2.1e-17 63.3 1.2 2.3e-08 34.4 0.1 3.3 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS17751.1 - 6.4e-15 55.5 0.3 4.8e-14 52.7 0.1 2.2 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOS17751.1 - 2.9e-13 49.7 7.6 7.6e-06 26.1 0.2 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS17751.1 - 2.2e-11 42.9 0.3 0.00012 22.2 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 KOS17751.1 - 1.4e-10 41.1 2.3 3.8e-05 23.9 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat Zip PF02535.22 KOS17752.1 - 2.5e-55 188.0 2.1 3.1e-55 187.7 2.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter HXXEE PF13787.6 KOS17752.1 - 0.81 10.5 7.3 22 5.9 3.3 3.2 2 1 0 2 2 2 0 Protein of unknown function with HXXEE motif Steroid_dh PF02544.16 KOS17753.1 - 2.9e-15 56.5 2.6 5.8e-15 55.6 2.6 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase LSM PF01423.22 KOS17754.1 - 4.7e-21 74.2 0.5 5.3e-21 74.1 0.5 1.0 1 0 0 1 1 1 1 LSM domain Sec23_trunk PF04811.15 KOS17755.1 - 2.1e-50 171.6 0.0 5.9e-50 170.1 0.0 1.7 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOS17755.1 - 6.1e-23 80.6 0.0 1.2e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOS17755.1 - 4.8e-17 62.5 0.0 7.9e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KOS17755.1 - 2.3e-16 59.6 4.8 5e-16 58.5 4.8 1.6 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOS17755.1 - 2e-07 30.8 0.0 4.3e-07 29.7 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat PTA_PTB PF01515.19 KOS17755.1 - 0.12 11.7 0.0 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Phosphate acetyl/butaryl transferase Linker_histone PF00538.19 KOS17756.1 - 2e-26 92.1 0.1 5.2e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 linker histone H1 and H5 family Mitofilin PF09731.9 KOS17756.1 - 3.9 6.2 29.5 4.7 5.9 29.5 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Hid1 PF12722.7 KOS17756.1 - 6.3 4.8 8.8 8 4.5 8.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TolA_bind_tri PF16331.5 KOS17757.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 TolA binding protein trimerisation DEAD PF00270.29 KOS17758.1 - 3.3e-42 144.2 0.0 4.9e-42 143.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17758.1 - 3.7e-28 98.1 0.5 4.2e-27 94.7 0.4 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17758.1 - 0.0033 17.4 0.0 0.0067 16.5 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 KOS17758.1 - 0.045 13.1 0.0 0.098 12.0 0.0 1.5 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit GRP PF07172.11 KOS17758.1 - 1.6 9.5 12.7 2.9 8.6 12.8 1.4 1 0 0 1 1 1 0 Glycine rich protein family Gti1_Pac2 PF09729.9 KOS17759.1 - 5.2e-43 147.2 1.9 2.4e-36 125.5 0.2 2.4 1 1 1 2 2 2 2 Gti1/Pac2 family tRNA-synt_2 PF00152.20 KOS17760.1 - 1.7e-82 277.0 0.0 5.4e-82 275.4 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOS17760.1 - 0.00042 20.3 0.0 0.00073 19.5 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOS17760.1 - 0.16 11.5 0.0 2.4 7.6 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) DUF2263 PF10021.9 KOS17761.1 - 1.7e-06 28.5 0.0 2.5e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) NOA36 PF06524.12 KOS17762.1 - 0.094 12.0 4.9 0.098 12.0 4.9 1.0 1 0 0 1 1 1 0 NOA36 protein Pox_Ag35 PF03286.14 KOS17762.1 - 0.095 12.5 3.8 0.099 12.4 3.8 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 KOS17762.1 - 0.74 9.5 3.4 0.77 9.4 3.4 1.1 1 0 0 1 1 1 0 FAM176 family Cytomega_UL84 PF06284.11 KOS17762.1 - 4.3 5.7 5.9 4.7 5.5 5.9 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ank_2 PF12796.7 KOS17763.1 - 1.2e-18 67.4 1.3 1.9e-09 38.0 1.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS17763.1 - 6.3e-13 47.7 2.4 0.0033 17.8 0.1 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 KOS17763.1 - 2.8e-12 46.6 8.7 3.9e-05 23.8 0.3 3.9 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 KOS17763.1 - 2.1e-10 40.5 8.1 0.0043 17.5 0.3 4.2 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOS17763.1 - 5.3e-10 39.6 7.7 7.4e-05 23.2 0.3 4.0 2 1 3 5 5 5 4 Ankyrin repeats (many copies) DUF4191 PF13829.6 KOS17763.1 - 1.2 8.5 6.0 1.8 7.8 6.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Bcl-2_BAD PF10514.9 KOS17764.1 - 0.056 13.9 6.5 0.082 13.4 6.5 1.2 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD CDC45 PF02724.14 KOS17764.1 - 0.16 10.2 0.5 0.16 10.2 0.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Phi-29_GP16_7 PF06720.11 KOS17764.1 - 0.17 11.7 0.3 0.25 11.2 0.3 1.2 1 0 0 1 1 1 0 Bacteriophage phi-29 early protein GP16.7 Menin PF05053.13 KOS17764.1 - 0.4 9.0 4.9 0.51 8.6 4.9 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 KOS17764.1 - 7.7 5.2 5.0 9.1 4.9 5.0 1.1 1 0 0 1 1 1 0 Presenilin FAD_binding_3 PF01494.19 KOS17765.1 - 1.3e-11 44.4 2.4 3.9e-06 26.4 0.4 2.8 2 1 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOS17765.1 - 0.00011 22.3 0.1 0.00029 21.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS17765.1 - 0.00015 21.5 0.9 0.00058 19.5 0.9 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase DUF3446 PF11928.8 KOS17765.1 - 0.0002 21.6 5.1 0.00036 20.8 5.1 1.3 1 0 0 1 1 1 1 Early growth response N-terminal domain ApbA PF02558.16 KOS17765.1 - 0.00048 19.8 0.0 0.00081 19.1 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TrkA_N PF02254.18 KOS17765.1 - 0.0097 16.2 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox_3 PF13738.6 KOS17765.1 - 0.011 15.0 0.1 0.021 14.1 0.1 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS17765.1 - 0.02 14.0 0.0 0.036 13.2 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain SR-25 PF10500.9 KOS17765.1 - 0.036 13.7 12.5 0.067 12.8 12.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pyr_redox PF00070.27 KOS17765.1 - 0.044 14.4 0.1 0.094 13.3 0.1 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS17765.1 - 0.21 10.8 0.0 0.28 10.4 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS17765.1 - 0.21 10.9 0.2 0.44 9.8 0.1 1.5 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF508 PF04370.12 KOS17765.1 - 3.1 7.5 6.7 5.5 6.7 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF508) DUF3140 PF11338.8 KOS17766.1 - 3.5e-32 110.7 0.6 3.5e-32 110.7 0.6 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF3140) Hva1_TUDOR PF11160.8 KOS17766.1 - 1.9e-15 56.8 7.5 1.4e-14 54.0 0.6 3.1 2 0 0 2 2 2 2 Hypervirulence associated proteins TUDOR domain Drc1-Sld2 PF11719.8 KOS17766.1 - 0.051 13.1 24.2 0.076 12.6 24.2 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein Nop14 PF04147.12 KOS17766.1 - 0.079 11.2 32.9 0.094 10.9 32.9 1.2 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 KOS17766.1 - 5.9 5.6 15.3 7.6 5.2 15.3 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sugar_tr PF00083.24 KOS17767.1 - 1.4e-67 228.6 10.8 1.5e-67 228.4 10.8 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS17767.1 - 4.4e-08 32.5 27.6 1.4e-05 24.2 21.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily ABC_tran PF00005.27 KOS17768.1 - 8.4e-51 172.1 0.0 1.7e-24 86.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane PF01061.24 KOS17768.1 - 8.3e-50 169.1 30.8 3.9e-28 98.3 5.0 3.0 3 0 0 3 3 3 2 ABC-2 type transporter AAA_21 PF13304.6 KOS17768.1 - 1.7e-15 57.6 2.0 0.0097 15.7 0.0 4.3 4 0 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOS17768.1 - 4e-09 37.1 6.4 0.00022 21.7 0.6 3.3 3 0 0 3 3 3 2 AAA ATPase domain SMC_N PF02463.19 KOS17768.1 - 4.3e-09 36.1 0.6 0.0017 17.9 0.1 4.0 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS17768.1 - 3.6e-08 33.0 0.8 0.0058 16.4 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOS17768.1 - 5.4e-08 32.9 0.1 0.0099 15.8 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KOS17768.1 - 7.4e-08 32.8 0.0 0.016 15.5 0.0 3.0 3 0 0 3 3 3 2 AAA domain AAA_23 PF13476.6 KOS17768.1 - 2.5e-07 31.4 5.2 0.0013 19.3 0.0 2.8 3 0 0 3 3 3 2 AAA domain AAA_25 PF13481.6 KOS17768.1 - 4.7e-07 29.6 2.6 0.0016 18.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.12 KOS17768.1 - 5.3e-07 29.7 0.0 0.011 15.6 0.0 2.5 2 0 0 2 2 2 2 NACHT domain AAA_30 PF13604.6 KOS17768.1 - 9e-07 28.8 0.4 0.006 16.3 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOS17768.1 - 1.8e-06 28.3 1.5 0.0062 16.8 0.1 3.1 3 0 0 3 3 2 2 AAA domain AAA_19 PF13245.6 KOS17768.1 - 7.8e-05 23.0 0.1 0.06 13.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 KOS17768.1 - 8.9e-05 22.1 1.2 0.25 10.9 0.1 2.3 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain T2SSE PF00437.20 KOS17768.1 - 9.3e-05 21.6 0.0 0.26 10.3 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein AAA_18 PF13238.6 KOS17768.1 - 0.00048 20.7 0.1 2.2 8.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 KOS17768.1 - 0.00054 19.9 0.0 0.35 10.7 0.0 2.4 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 KOS17768.1 - 0.00099 19.5 0.0 1.6 9.2 0.0 2.5 2 0 0 2 2 2 1 RNA helicase AAA_24 PF13479.6 KOS17768.1 - 0.0016 18.2 0.2 1 9.0 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOS17768.1 - 0.0017 18.5 0.2 0.75 10.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 KOS17768.1 - 0.002 18.1 0.9 0.4 10.6 0.1 3.1 4 0 0 4 4 3 1 NTPase MMR_HSR1 PF01926.23 KOS17768.1 - 0.0024 17.9 2.4 0.37 10.9 0.1 2.5 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF2075 PF09848.9 KOS17768.1 - 0.0026 17.1 0.1 0.17 11.1 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 KOS17768.1 - 0.0038 17.6 0.1 2.1 8.8 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MobB PF03205.14 KOS17768.1 - 0.0049 16.8 0.3 0.8 9.6 0.0 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B FtsK_SpoIIIE PF01580.18 KOS17768.1 - 0.005 16.2 1.3 0.26 10.6 0.1 2.9 3 0 0 3 3 3 1 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 KOS17768.1 - 0.0094 15.8 0.3 1.7 8.4 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Pox_A32 PF04665.12 KOS17768.1 - 0.01 15.3 0.6 0.46 9.9 0.1 2.2 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_5 PF07728.14 KOS17768.1 - 0.011 15.8 0.7 11 6.0 0.0 3.5 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) Roc PF08477.13 KOS17768.1 - 0.019 15.2 0.6 5.6 7.2 0.1 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 KOS17768.1 - 0.021 14.6 0.5 4.6 6.9 0.1 2.6 3 0 0 3 3 3 0 AAA ATPase domain IstB_IS21 PF01695.17 KOS17768.1 - 0.036 13.8 0.2 9.5 5.9 0.0 3.5 4 0 0 4 4 4 0 IstB-like ATP binding protein SbcCD_C PF13558.6 KOS17768.1 - 0.037 14.3 0.3 6.9 7.0 0.0 3.4 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ABC_ATPase PF09818.9 KOS17768.1 - 0.047 12.5 0.6 0.76 8.5 0.2 2.4 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_17 PF13207.6 KOS17768.1 - 0.072 13.5 0.1 2.3 8.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 KOS17768.1 - 0.094 12.0 0.1 1.8 7.8 0.0 2.1 2 0 0 2 2 2 0 Septin SRP54 PF00448.22 KOS17768.1 - 0.1 12.2 0.4 5 6.7 0.1 2.2 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PhoH PF02562.16 KOS17768.1 - 0.12 11.9 0.1 4.7 6.6 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein PDR_CDR PF06422.12 KOS17768.1 - 0.12 12.3 0.1 0.3 11.0 0.1 1.6 1 0 0 1 1 1 0 CDR ABC transporter Viral_helicase1 PF01443.18 KOS17768.1 - 0.13 12.0 0.1 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 KOS17768.1 - 0.13 11.5 0.3 9.6 5.4 0.1 2.3 2 0 0 2 2 2 0 Zeta toxin PduV-EutP PF10662.9 KOS17768.1 - 0.13 12.0 0.3 17 5.2 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 KOS17768.1 - 0.15 11.5 0.1 16 4.9 0.0 2.3 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DnaB_C PF03796.15 KOS17768.1 - 0.23 10.8 3.3 4.5 6.5 0.0 3.0 3 0 0 3 3 3 0 DnaB-like helicase C terminal domain Cytidylate_kin PF02224.18 KOS17768.1 - 0.23 11.2 0.5 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase Dynamin_N PF00350.23 KOS17768.1 - 0.4 10.7 0.9 22 5.1 0.1 2.5 2 0 0 2 2 2 0 Dynamin family PRK PF00485.18 KOS17768.1 - 0.65 9.7 3.7 2.4 7.9 0.0 2.5 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family Sortase PF04203.13 KOS17770.1 - 0.11 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Sortase domain Amidohydro_1 PF01979.20 KOS17771.1 - 2.4e-26 92.9 0.0 1.1e-14 54.5 0.0 2.6 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 KOS17771.1 - 7.3e-14 52.1 0.1 1.8e-07 31.0 0.0 2.5 3 0 0 3 3 3 2 Amidohydrolase family polyprenyl_synt PF00348.17 KOS17772.1 - 8e-76 254.5 0.0 1.1e-75 254.1 0.0 1.2 1 0 0 1 1 1 1 Polyprenyl synthetase HEPPP_synt_1 PF07307.11 KOS17772.1 - 0.015 14.9 0.0 0.024 14.3 0.0 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Cys_Met_Meta_PP PF01053.20 KOS17773.1 - 2.9e-35 121.5 0.0 3.7e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOS17773.1 - 0.0085 15.3 0.0 0.013 14.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Pterin_bind PF00809.22 KOS17774.1 - 5.5e-80 268.6 0.0 6.9e-80 268.2 0.0 1.1 1 0 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 KOS17774.1 - 5.8e-28 97.6 0.0 1.3e-27 96.5 0.0 1.6 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) NMO PF03060.15 KOS17775.1 - 2.4e-54 184.9 0.3 3.7e-54 184.3 0.3 1.3 1 0 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 KOS17775.1 - 3.4e-11 42.8 0.2 1.2e-10 40.9 0.2 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOS17775.1 - 3.5e-06 26.3 3.5 5.4e-06 25.7 3.5 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 KOS17775.1 - 0.025 13.7 2.2 0.043 12.9 2.2 1.3 1 0 0 1 1 1 0 Conserved region in glutamate synthase NanE PF04131.14 KOS17775.1 - 0.041 13.1 0.1 0.12 11.6 0.1 1.7 1 1 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase DHO_dh PF01180.21 KOS17775.1 - 0.048 12.9 0.1 0.077 12.2 0.1 1.3 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase TIM21 PF08294.11 KOS17776.1 - 1e-43 148.7 0.0 1.4e-43 148.3 0.0 1.2 1 0 0 1 1 1 1 TIM21 Coa1 PF08695.10 KOS17776.1 - 0.0042 16.8 0.0 0.0067 16.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 MFS_1 PF07690.16 KOS17777.1 - 1.5e-37 129.3 50.3 3.6e-37 128.1 47.8 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS17777.1 - 2.8e-13 49.2 19.4 4.4e-13 48.5 19.4 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 KOS17777.1 - 0.3 9.3 9.8 1.4 7.1 0.8 2.9 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family ArfGap PF01412.18 KOS17778.1 - 0.00026 21.0 0.5 0.00074 19.6 0.5 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf ArfGap PF01412.18 KOS17779.1 - 6.3e-25 87.5 0.2 7.1e-25 87.4 0.2 1.0 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 KOS17779.1 - 0.1 12.8 1.8 5.3 7.3 0.2 2.1 2 0 0 2 2 2 0 B-box zinc finger Tachystatin_B PF11478.8 KOS17780.1 - 0.65 10.0 4.2 1.6 8.7 4.2 1.6 1 0 0 1 1 1 0 Antimicrobial chitin binding protein tachystatin B Plasmodium_Vir PF05795.11 KOS17780.1 - 0.66 9.3 10.7 0.89 8.9 10.7 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein SOG2 PF10428.9 KOS17780.1 - 1.7 7.7 28.0 2.3 7.3 28.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein ACBP PF00887.19 KOS17781.1 - 7.8e-21 74.1 1.3 9e-21 73.9 1.3 1.1 1 0 0 1 1 1 1 Acyl CoA binding protein DUF5048 PF16467.5 KOS17781.1 - 0.1 12.9 0.1 0.14 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5048) hSac2 PF12456.8 KOS17781.1 - 0.12 12.1 0.1 1.9 8.2 0.1 2.0 1 1 0 1 1 1 0 Inositol phosphatase zf-H2C2_2 PF13465.6 KOS17782.1 - 1.2e-06 28.7 11.0 2.1e-05 24.7 3.5 4.7 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 KOS17782.1 - 1.5e-05 25.1 14.0 0.00047 20.4 4.5 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS17782.1 - 0.054 14.4 3.1 0.054 14.4 3.1 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOS17782.1 - 0.056 13.7 0.4 0.056 13.7 0.4 3.4 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF2225 PF09986.9 KOS17782.1 - 0.47 10.1 0.9 1 9.0 0.9 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) PAT1 PF09770.9 KOS17782.1 - 1.8 6.7 8.0 2.5 6.2 8.0 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Bromodomain PF00439.25 KOS17783.1 - 9.2e-16 57.7 0.0 1.7e-15 56.9 0.0 1.4 1 0 0 1 1 1 1 Bromodomain DEAD PF00270.29 KOS17784.1 - 7.1e-43 146.4 0.5 1e-42 145.9 0.5 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS17784.1 - 3.1e-20 72.6 0.0 9.1e-20 71.1 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17784.1 - 0.0022 18.0 0.0 0.0034 17.4 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOS17784.1 - 0.039 14.2 0.2 0.11 12.7 0.2 1.7 1 1 0 1 1 1 0 AAA domain ERCC3_RAD25_C PF16203.5 KOS17784.1 - 0.14 11.4 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase WD40 PF00400.32 KOS17785.1 - 9.7e-18 64.2 10.9 0.00069 20.4 0.0 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17785.1 - 0.00079 19.7 0.0 0.12 12.6 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DAZAP2 PF11029.8 KOS17785.1 - 0.042 14.8 0.2 0.042 14.8 0.2 2.0 1 1 1 2 2 2 0 DAZ associated protein 2 (DAZAP2) Rav1p_C PF12234.8 KOS17785.1 - 0.25 9.7 0.0 0.4 9.0 0.0 1.2 1 0 0 1 1 1 0 RAVE protein 1 C terminal 2OG-FeII_Oxy_2 PF13532.6 KOS17786.1 - 2.4e-37 129.0 0.0 3.1e-37 128.7 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-GRF PF06839.12 KOS17786.1 - 1.2e-08 34.9 6.2 2.9e-08 33.7 6.2 1.7 1 0 0 1 1 1 1 GRF zinc finger RibD_C PF01872.17 KOS17787.1 - 6e-35 120.9 0.0 7e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain PfkB PF00294.24 KOS17788.1 - 6.6e-57 193.1 0.1 7.8e-57 192.9 0.1 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CHAT PF12770.7 KOS17788.1 - 0.0042 16.5 0.1 0.011 15.1 0.2 1.7 1 1 0 1 1 1 1 CHAT domain UQ_con PF00179.26 KOS17789.1 - 1.8e-08 34.2 0.8 3.7e-08 33.1 0.8 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TFIIA PF03153.13 KOS17789.1 - 0.033 14.2 12.4 0.047 13.7 12.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 KOS17789.1 - 0.12 11.1 1.2 0.15 10.8 1.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4805 PF16063.5 KOS17789.1 - 1.8 7.9 7.1 17 4.6 5.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) DUF4512 PF14975.6 KOS17789.1 - 6.3 7.6 10.8 6.9 7.5 1.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Pex14_N PF04695.13 KOS17789.1 - 7.5 7.2 15.9 1.7 9.3 7.3 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ccdc124 PF06244.12 KOS17790.1 - 5.5e-30 104.6 20.3 1.5e-28 100.0 20.3 2.2 1 1 0 1 1 1 1 Coiled-coil domain-containing protein 124 /Oxs1 DUF3235 PF11574.8 KOS17790.1 - 1.3 9.9 0.0 1.3 9.9 0.0 3.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3235) DNApol_Exo PF18136.1 KOS17790.1 - 2.7 7.1 8.8 4.6 6.3 8.8 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Zip PF02535.22 KOS17790.1 - 3.2 6.9 3.8 3.1 6.9 3.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MFS_1 PF07690.16 KOS17791.1 - 4.9e-38 131.0 10.4 4.9e-38 131.0 10.4 2.0 1 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS17791.1 - 2.7e-11 43.0 1.4 2.7e-11 43.0 1.4 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOS17791.1 - 0.0007 18.6 16.5 0.0017 17.3 4.0 2.9 1 1 1 2 2 2 2 MFS_1 like family Nuc_H_symport PF03825.16 KOS17791.1 - 0.0033 16.5 1.1 0.0033 16.5 1.1 1.9 2 0 0 2 2 2 1 Nucleoside H+ symporter SpoIIIAH PF12685.7 KOS17792.1 - 3e-06 27.2 11.7 3.7e-06 26.9 11.7 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein V_ATPase_I PF01496.19 KOS17792.1 - 1.5e-05 23.2 23.7 1.8e-05 22.9 23.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CLN3 PF02487.17 KOS17792.1 - 2.5e-05 23.5 13.9 3e-05 23.3 13.9 1.0 1 0 0 1 1 1 1 CLN3 protein SID-1_RNA_chan PF13965.6 KOS17792.1 - 4.8e-05 22.0 6.9 5.6e-05 21.8 6.9 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Zip PF02535.22 KOS17792.1 - 8.2e-05 22.0 6.1 9.5e-05 21.8 6.1 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter TRAP_alpha PF03896.16 KOS17792.1 - 0.00027 20.2 8.9 0.00033 20.0 8.9 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit RNA_pol_Rpc4 PF05132.14 KOS17792.1 - 0.00034 21.1 17.9 0.00044 20.7 17.9 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 Connexin PF00029.19 KOS17792.1 - 0.00094 19.0 24.7 0.0016 18.3 24.7 1.4 1 1 0 1 1 1 1 Connexin DUF4746 PF15928.5 KOS17792.1 - 0.0015 18.0 15.9 0.0017 17.9 15.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) MAP17 PF15807.5 KOS17792.1 - 0.0027 17.9 15.1 0.0038 17.5 15.1 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SARAF PF06682.12 KOS17792.1 - 0.0038 16.9 12.2 0.0048 16.6 12.2 1.0 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SpoIIP PF07454.11 KOS17792.1 - 0.006 16.1 21.8 0.0079 15.7 21.8 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Tmp39 PF10271.9 KOS17792.1 - 0.023 13.7 5.6 0.027 13.5 5.6 1.0 1 0 0 1 1 1 0 Putative transmembrane protein Spore_coat_CotO PF14153.6 KOS17792.1 - 0.026 14.5 27.0 0.027 14.4 27.0 1.0 1 0 0 1 1 1 0 Spore coat protein CotO CSG2 PF16965.5 KOS17792.1 - 0.029 13.3 11.3 0.035 13.1 11.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 KOS17792.1 - 0.031 13.2 10.7 0.036 13.0 10.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) YABBY PF04690.13 KOS17792.1 - 0.032 14.8 18.1 0.036 14.6 18.1 1.1 1 0 0 1 1 1 0 YABBY protein DUF1180 PF06679.12 KOS17792.1 - 0.032 14.6 3.4 0.045 14.2 3.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Neur_chan_memb PF02932.16 KOS17792.1 - 0.033 14.3 16.8 0.04 14.0 16.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 KOS17792.1 - 0.034 14.3 13.4 0.042 13.9 13.4 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region SLC12 PF03522.15 KOS17792.1 - 0.034 13.2 21.5 0.038 13.0 21.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF4228 PF14009.6 KOS17792.1 - 0.043 14.2 13.2 0.048 14.0 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Scs3p PF10261.9 KOS17792.1 - 0.047 13.2 9.2 0.064 12.8 9.2 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Mem_trans PF03547.18 KOS17792.1 - 0.054 11.9 5.9 0.063 11.7 5.9 1.1 1 0 0 1 1 1 0 Membrane transport protein FAM76 PF16046.5 KOS17792.1 - 0.062 12.6 26.9 0.075 12.4 26.9 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4692 PF15763.5 KOS17792.1 - 0.069 13.6 5.4 0.083 13.4 5.4 1.0 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) CBP_BcsG PF11658.8 KOS17792.1 - 0.088 11.2 15.5 0.1 11.0 15.5 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG G6B PF15096.6 KOS17792.1 - 0.1 12.3 4.3 0.15 11.8 4.3 1.3 1 0 0 1 1 1 0 G6B family BORG_CEP PF14957.6 KOS17792.1 - 0.11 13.6 16.1 0.13 13.4 16.1 1.1 1 0 0 1 1 1 0 Cdc42 effector CobT PF06213.12 KOS17792.1 - 0.12 11.7 30.0 0.16 11.4 30.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tmemb_9 PF05434.11 KOS17792.1 - 0.13 12.1 20.2 0.18 11.7 20.2 1.2 1 0 0 1 1 1 0 TMEM9 HemX PF04375.14 KOS17792.1 - 0.14 11.4 29.1 0.17 11.2 29.1 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase IgaA PF07095.11 KOS17792.1 - 0.14 10.1 8.9 0.17 9.9 8.9 1.0 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA SAPS PF04499.15 KOS17792.1 - 0.15 10.8 15.7 0.17 10.7 15.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein O-antigen_lig PF13425.6 KOS17792.1 - 0.17 10.7 15.0 0.21 10.3 15.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein 7tm_7 PF08395.12 KOS17792.1 - 0.17 11.1 1.3 0.19 10.9 1.3 1.2 1 0 0 1 1 1 0 7tm Chemosensory receptor NEMP PF10225.9 KOS17792.1 - 0.19 11.3 10.2 0.26 10.9 10.2 1.2 1 0 0 1 1 1 0 NEMP family Acatn PF13000.7 KOS17792.1 - 0.2 10.1 4.6 0.22 10.0 4.6 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Velvet PF11754.8 KOS17792.1 - 0.2 11.5 14.7 0.23 11.4 14.7 1.0 1 0 0 1 1 1 0 Velvet factor NicO PF03824.16 KOS17792.1 - 0.21 10.9 0.5 0.25 10.6 0.5 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein MMM1 PF10296.9 KOS17792.1 - 0.22 10.6 12.6 0.27 10.2 12.6 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 MMU163 PF17119.5 KOS17792.1 - 0.22 10.6 8.9 0.32 10.1 8.9 1.3 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF2448 PF10476.9 KOS17792.1 - 0.23 11.3 3.0 0.34 10.7 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Ly49 PF08391.10 KOS17792.1 - 0.25 11.7 15.1 0.39 11.1 15.1 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF2052 PF09747.9 KOS17792.1 - 0.28 11.3 25.4 0.34 11.0 25.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4834 PF16118.5 KOS17792.1 - 0.32 12.0 28.7 3.5 8.6 28.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Nucleoside_tran PF01733.18 KOS17792.1 - 0.32 10.3 8.0 0.39 10.1 8.0 1.2 1 0 0 1 1 1 0 Nucleoside transporter Ni_hydr_CYTB PF01292.20 KOS17792.1 - 0.32 10.6 1.6 0.48 10.0 1.6 1.4 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 DUF2828 PF11443.8 KOS17792.1 - 0.32 9.0 26.8 0.39 8.7 26.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Paf1 PF03985.13 KOS17792.1 - 0.34 9.9 27.7 0.4 9.6 27.7 1.1 1 0 0 1 1 1 0 Paf1 Otopetrin PF03189.13 KOS17792.1 - 0.34 9.7 11.5 0.43 9.3 11.5 1.1 1 0 0 1 1 1 0 Otopetrin DUF913 PF06025.12 KOS17792.1 - 0.36 9.7 14.7 0.41 9.6 14.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4446 PF14584.6 KOS17792.1 - 0.41 10.6 14.8 0.51 10.3 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Hid1 PF12722.7 KOS17792.1 - 0.44 8.6 18.7 0.49 8.5 18.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PIG-P PF08510.12 KOS17792.1 - 0.47 10.4 1.7 0.92 9.4 1.7 1.6 1 1 0 1 1 1 0 PIG-P Sre PF03125.18 KOS17792.1 - 0.55 9.3 4.9 0.66 9.1 4.9 1.2 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor CCDC53 PF10152.9 KOS17792.1 - 0.65 10.4 20.7 1.1 9.7 20.7 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Protocadherin PF08374.11 KOS17792.1 - 0.66 9.9 15.7 0.91 9.5 15.7 1.2 1 0 0 1 1 1 0 Protocadherin Miga PF10265.9 KOS17792.1 - 0.68 8.8 13.3 0.79 8.6 13.3 1.0 1 0 0 1 1 1 0 Mitoguardin DUF2151 PF10221.9 KOS17792.1 - 0.7 8.4 19.5 0.81 8.2 19.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator ALMT PF11744.8 KOS17792.1 - 0.83 8.4 19.7 0.96 8.2 19.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Vfa1 PF08432.10 KOS17792.1 - 0.88 9.9 36.8 1.1 9.5 36.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 API5 PF05918.11 KOS17792.1 - 1 8.1 24.3 1.2 7.8 24.3 1.0 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) DUF3807 PF12720.7 KOS17792.1 - 1.1 9.5 37.5 1.3 9.2 37.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4638 PF15472.6 KOS17792.1 - 1.1 8.9 27.8 1.2 8.8 27.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) Gti1_Pac2 PF09729.9 KOS17792.1 - 1.1 9.3 24.4 1.4 9.0 24.4 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family HSNSD PF12062.8 KOS17792.1 - 1.1 7.8 12.0 1.3 7.6 12.0 1.2 1 0 0 1 1 1 0 heparan sulfate-N-deacetylase DUF4569 PF15133.6 KOS17792.1 - 1.2 8.8 23.1 1.4 8.6 23.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Endostatin PF06482.11 KOS17792.1 - 1.6 8.1 19.0 1.9 7.9 19.0 1.0 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Sugar_tr PF00083.24 KOS17792.1 - 1.7 7.4 8.3 2 7.2 8.3 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter PIP5K PF01504.18 KOS17792.1 - 2 7.6 19.7 2.4 7.3 19.7 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase PA26 PF04636.13 KOS17792.1 - 2 7.3 15.9 2.3 7.0 15.9 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DAG_kinase_N PF14513.6 KOS17792.1 - 2 8.6 23.5 2.5 8.3 23.5 1.0 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus XRN_M PF17846.1 KOS17792.1 - 2.1 7.2 19.0 2.5 7.0 19.0 1.0 1 0 0 1 1 1 0 Xrn1 helical domain RPN2_C PF18004.1 KOS17792.1 - 2.2 8.2 35.5 3.7 7.4 35.5 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PSK PF06404.12 KOS17792.1 - 2.2 9.4 18.2 3.5 8.7 18.2 1.4 1 0 0 1 1 1 0 Phytosulfokine precursor protein (PSK) FAM176 PF14851.6 KOS17792.1 - 2.3 7.9 24.8 0.14 11.8 8.2 2.0 1 1 1 2 2 2 0 FAM176 family m04gp34like PF12216.8 KOS17792.1 - 2.4 7.7 6.4 3.2 7.2 6.4 1.2 1 0 0 1 1 1 0 Immune evasion protein NPR3 PF03666.13 KOS17792.1 - 2.4 6.9 31.3 2.9 6.6 31.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 KOS17792.1 - 2.7 6.2 28.3 3.2 5.9 28.3 1.0 1 0 0 1 1 1 0 CDC45-like protein UPF0565 PF10561.9 KOS17792.1 - 3.1 6.9 14.6 3.6 6.7 14.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 DUF2615 PF11027.8 KOS17792.1 - 3.8 7.7 22.8 8.3e+03 -3.0 22.8 2.5 1 1 0 1 1 0 0 Protein of unknown function (DUF2615) Ndc1_Nup PF09531.10 KOS17792.1 - 4 6.0 17.4 4.7 5.8 17.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PAT1 PF09770.9 KOS17792.1 - 4 5.6 31.8 4.5 5.4 31.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Tim54 PF11711.8 KOS17792.1 - 4.2 6.1 26.7 6.1 5.5 26.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF1168 PF06658.12 KOS17792.1 - 5.3 6.9 43.2 9 6.1 43.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Peroxin-3 PF04882.12 KOS17792.1 - 5.3 5.9 22.7 5.9 5.8 22.7 1.0 1 0 0 1 1 1 0 Peroxin-3 DUF5378 PF17349.2 KOS17792.1 - 5.8 6.1 5.8 7.6 5.8 5.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5378) LicD PF04991.13 KOS17792.1 - 6.3 6.9 18.9 7.2 6.7 18.9 1.0 1 0 0 1 1 1 0 LicD family NARP1 PF12569.8 KOS17792.1 - 6.8 5.5 36.9 8.3 5.2 36.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SRP-alpha_N PF04086.13 KOS17792.1 - 7 6.5 31.9 8.9 6.1 31.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal GAGA_bind PF06217.12 KOS17792.1 - 7.1 6.8 26.5 9.9 6.4 26.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family PepSY_TM_like_2 PF16357.5 KOS17792.1 - 7.6 6.5 9.9 8.9 6.2 9.9 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like FAM60A PF15396.6 KOS17792.1 - 7.7 6.5 27.4 9.2 6.2 27.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Rtf2 PF04641.12 KOS17792.1 - 7.8 5.8 37.0 9.7 5.5 37.0 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Fungal_trans PF04082.18 KOS17793.1 - 1.7e-28 99.4 0.0 3.3e-28 98.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain DnaJ PF00226.31 KOS17794.1 - 7.8e-25 86.8 0.6 2.4e-24 85.2 0.6 1.9 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_jaz PF12171.8 KOS17794.1 - 2.3e-10 40.5 1.6 4.8e-10 39.5 1.6 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS17794.1 - 1.4e-08 34.9 2.4 3.5e-08 33.6 2.4 1.8 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KOS17794.1 - 8.1e-05 22.9 1.1 0.00018 21.8 1.1 1.5 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KOS17794.1 - 0.00041 20.6 0.5 0.0011 19.3 0.5 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 KOS17794.1 - 0.002 18.1 1.2 0.0044 17.0 1.2 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 KOS17794.1 - 0.0039 17.9 0.3 0.011 16.5 0.3 1.9 1 0 0 1 1 1 1 C2H2-type zinc finger Myc_N PF01056.18 KOS17794.1 - 0.035 14.0 2.4 0.048 13.6 2.4 1.2 1 0 0 1 1 1 0 Myc amino-terminal region G-patch PF01585.23 KOS17795.1 - 1.2e-10 41.0 1.5 1.8e-10 40.6 1.5 1.3 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOS17795.1 - 0.0014 18.6 1.4 0.0019 18.2 1.4 1.2 1 0 0 1 1 1 1 G-patch domain Histone_H2A_C PF16211.5 KOS17796.1 - 2.3e-20 72.0 2.4 4.8e-20 71.0 2.4 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 KOS17796.1 - 5.2e-17 62.4 0.0 6.8e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOS17796.1 - 0.00014 22.1 0.0 0.00018 21.7 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Vmethyltransf PF01660.17 KOS17798.1 - 0.18 10.7 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Viral methyltransferase WD40 PF00400.32 KOS17800.1 - 7.4e-07 29.8 13.4 0.0086 16.9 0.7 5.8 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17800.1 - 0.0068 16.7 0.0 2 8.8 0.1 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain NOA36 PF06524.12 KOS17800.1 - 0.083 12.2 12.9 0.15 11.3 12.9 1.3 1 0 0 1 1 1 0 NOA36 protein Osteopontin PF00865.18 KOS17800.1 - 0.13 11.8 18.1 0.21 11.0 18.1 1.2 1 0 0 1 1 1 0 Osteopontin VID27_N PF17748.1 KOS17800.1 - 0.2 11.5 3.8 0.48 10.3 3.8 1.6 1 0 0 1 1 1 0 VID27 N-terminal region Nop14 PF04147.12 KOS17800.1 - 0.65 8.1 9.4 1 7.5 9.4 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 KOS17800.1 - 1.2 7.6 5.6 1.7 7.1 5.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 KOS17800.1 - 1.5 6.8 14.7 2.2 6.2 14.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Spt20 PF12090.8 KOS17801.1 - 2.9 7.4 10.2 4.1 7.0 10.2 1.1 1 0 0 1 1 1 0 Spt20 family HhH-GPD PF00730.25 KOS17802.1 - 0.00071 20.0 0.0 0.0013 19.2 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein p450 PF00067.22 KOS17803.1 - 2.5e-21 76.0 0.0 3.7e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 SUIM_assoc PF16619.5 KOS17804.1 - 0.036 14.1 0.0 0.036 14.1 0.0 5.8 5 1 1 6 6 6 0 Unstructured region C-term to UIM in Ataxin3 DUF202 PF02656.15 KOS17804.1 - 0.38 11.2 3.2 1.9 9.0 0.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF1700 PF08006.11 KOS17804.1 - 0.4 10.2 1.1 0.65 9.5 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) JIP_LZII PF16471.5 KOS17804.1 - 9.9 6.4 11.0 3.8 7.8 2.3 2.9 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Glyco_hydro_72 PF03198.14 KOS17805.1 - 4.2e-125 417.2 5.0 5.3e-125 416.9 5.0 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 KOS17805.1 - 2.1e-19 70.0 3.3 4.7e-19 68.8 3.3 1.7 1 0 0 1 1 1 1 X8 domain Glyco_hydro_2_C PF02836.17 KOS17805.1 - 0.0004 19.6 0.8 0.0018 17.5 0.8 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Frag1 PF10277.9 KOS17806.1 - 1.9e-38 132.2 8.6 1.9e-38 132.2 8.6 3.0 3 0 0 3 3 3 1 Frag1/DRAM/Sfk1 family DUF4536 PF15055.6 KOS17806.1 - 0.019 15.2 0.7 0.13 12.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) Exo_endo_phos PF03372.23 KOS17806.1 - 0.069 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF3918 PF13056.6 KOS17806.1 - 7.3 6.3 7.2 24 4.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3918) U3_assoc_6 PF08640.11 KOS17807.1 - 3.6e-27 94.2 0.1 3e-25 88.1 0.2 3.3 4 0 0 4 4 4 1 U3 small nucleolar RNA-associated protein 6 Img2 PF05046.14 KOS17809.1 - 4.3e-20 71.8 0.1 5.5e-20 71.5 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DUF1744 PF08490.12 KOS17810.1 - 2.1e-151 504.0 0.0 3.2e-151 503.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 KOS17810.1 - 4.2e-76 256.3 0.1 7.4e-76 255.5 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 KOS17810.1 - 1.2e-15 57.1 0.1 6.9e-13 48.1 0.1 3.4 3 1 0 3 3 3 2 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 KOS17810.1 - 3.3e-09 36.7 0.1 9.1e-09 35.3 0.1 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 KOS17810.1 - 3.3e-06 27.2 0.0 1.1e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 RNase_H superfamily CUE PF02845.16 KOS17811.1 - 6.6e-05 22.5 0.0 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 CUE domain zf-CCCH_4 PF18044.1 KOS17812.1 - 2e-08 33.9 3.4 3.8e-08 33.0 3.4 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf-CCCH PF00642.24 KOS17812.1 - 1.5e-06 27.9 2.7 2.9e-06 27.0 2.7 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOS17812.1 - 1.6e-06 27.9 7.3 3.2e-06 27.0 7.3 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 KOS17812.1 - 0.022 15.4 0.4 0.079 13.7 0.4 2.0 1 0 0 1 1 1 0 Torus domain zf-CCCH_3 PF15663.5 KOS17812.1 - 0.054 13.7 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOS17812.1 - 0.067 13.7 4.3 0.15 12.6 4.3 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger p450 PF00067.22 KOS17813.1 - 4e-65 220.4 0.0 5.2e-65 220.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 eIF3_N PF09440.10 KOS17814.1 - 8.7e-43 146.0 1.0 1.8e-42 144.9 1.0 1.6 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain PCI PF01399.27 KOS17814.1 - 1.6e-12 47.8 0.0 3.6e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 PCI domain TPR_14 PF13428.6 KOS17814.1 - 0.023 15.5 0.8 4.6 8.3 0.2 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Ead_Ea22 PF13935.6 KOS17814.1 - 0.13 12.9 0.4 8.7 7.0 0.0 2.4 2 0 0 2 2 2 0 Ead/Ea22-like protein His_Phos_2 PF00328.22 KOS17815.1 - 1e-110 370.7 0.2 1.7e-110 370.0 0.2 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 KOS17815.1 - 1.1e-35 121.7 0.0 2.2e-35 120.7 0.0 1.5 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 KOS17815.1 - 2.1e-05 24.2 0.0 4.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 RimK-like ATP-grasp domain Utp21 PF04192.12 KOS17816.1 - 6e-82 274.6 0.0 8.7e-82 274.1 0.0 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 KOS17816.1 - 3.3e-17 62.5 16.3 1.6e-06 28.7 0.3 8.3 8 1 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17816.1 - 1.3e-12 47.8 0.0 0.17 12.2 0.0 6.1 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS17816.1 - 1.2e-06 27.5 0.0 0.67 8.5 0.0 3.2 3 0 0 3 3 3 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 KOS17816.1 - 1.3e-06 27.7 0.0 0.0014 17.6 0.0 3.0 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 KOS17816.1 - 9.8e-06 24.3 0.0 1.9e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 KOS17816.1 - 0.0013 17.5 0.0 0.81 8.4 0.0 2.7 1 1 2 3 3 3 2 Nup133 N terminal like Ge1_WD40 PF16529.5 KOS17816.1 - 0.25 10.2 0.0 2.8 6.8 0.0 2.5 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltr_RsmB-F PF01189.17 KOS17817.1 - 2.6e-31 108.9 0.0 5e-24 85.1 0.0 3.2 3 0 0 3 3 3 2 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 KOS17817.1 - 0.13 12.3 0.0 0.28 11.3 0.0 1.6 1 1 0 1 1 1 0 FtsJ-like methyltransferase GTP1_OBG PF01018.22 KOS17818.1 - 1.5e-41 141.6 0.0 6.4e-31 107.0 0.7 2.3 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 KOS17818.1 - 1.2e-22 80.1 0.0 2.2e-22 79.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS17818.1 - 2.6e-06 27.1 0.0 5.6e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B ABC_tran PF00005.27 KOS17818.1 - 0.037 14.5 0.0 0.037 14.5 0.0 2.1 2 0 0 2 2 2 0 ABC transporter MeaB PF03308.16 KOS17818.1 - 0.13 11.2 4.7 0.38 9.7 0.0 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Arf PF00025.21 KOS17818.1 - 0.14 11.6 0.0 0.38 10.2 0.0 1.7 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_18 PF13238.6 KOS17818.1 - 0.19 12.2 2.1 0.47 11.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOS17818.1 - 0.2 12.2 8.6 3.1 8.2 6.9 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KOS17818.1 - 0.85 9.7 3.2 4.7 7.2 0.0 2.6 3 0 0 3 3 3 0 Dynamin family RNA_pol_Rpb5_C PF01191.19 KOS17820.1 - 3.3e-34 116.6 0.1 2.6e-33 113.7 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 KOS17820.1 - 6.3e-26 90.8 0.0 9.8e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Mrr_cat PF04471.12 KOS17820.1 - 0.082 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease Imm58 PF15581.6 KOS17821.1 - 0.25 11.5 1.0 1 9.5 0.2 2.3 2 0 0 2 2 2 0 Immunity protein 58 COX2_TM PF02790.15 KOS17821.1 - 1.1 9.5 6.2 0.15 12.2 0.5 2.4 2 1 1 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain CBFD_NFYB_HMF PF00808.23 KOS17822.1 - 0.0034 17.6 0.0 0.0055 17.0 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOS17822.1 - 0.037 14.1 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Replic_Relax PF13814.6 KOS17822.1 - 0.067 13.2 0.1 0.081 13.0 0.1 1.2 1 0 0 1 1 1 0 Replication-relaxation Sld7_C PF18596.1 KOS17822.1 - 0.099 12.8 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Sld7 C-terminal domain CENP-T_C PF15511.6 KOS17822.1 - 0.14 12.3 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Acetyltransf_1 PF00583.25 KOS17823.1 - 0.002 18.4 0.0 0.0038 17.5 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SPX PF03105.19 KOS17823.1 - 0.039 13.9 1.5 0.056 13.4 1.5 1.2 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 KOS17823.1 - 0.16 10.8 4.3 1.7 7.4 0.5 2.1 2 0 0 2 2 2 0 Golgi-body localisation protein domain MASE5 PF17178.4 KOS17823.1 - 0.24 11.2 1.5 0.38 10.6 1.5 1.2 1 0 0 1 1 1 0 Membrane-associated sensor EBP50_C PF09007.11 KOS17823.1 - 2.3 9.2 8.6 7 7.7 0.8 2.2 2 0 0 2 2 2 0 EBP50, C-terminal Ysc84 PF04366.12 KOS17825.1 - 3.5e-22 78.5 0.0 6.2e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Las17-binding protein actin regulator Acetyltransf_1 PF00583.25 KOS17826.1 - 0.00026 21.2 0.0 0.00041 20.6 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOS17826.1 - 0.012 16.0 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Pribosyltran PF00156.27 KOS17827.1 - 4.1e-17 62.2 0.9 5.8e-17 61.6 0.9 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOS17827.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Methyltransf_8 PF05148.15 KOS17828.1 - 6.3e-62 209.3 0.2 8.6e-58 195.8 0.0 3.6 2 2 1 3 3 3 3 Hypothetical methyltransferase Methyltransf_11 PF08241.12 KOS17828.1 - 1.8e-05 25.3 0.0 7.1e-05 23.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS17828.1 - 0.0013 19.4 0.0 0.049 14.3 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS17828.1 - 0.015 15.3 1.4 0.81 9.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Asp_protease PF09668.10 KOS17829.1 - 2.6e-57 192.0 0.1 3.7e-57 191.5 0.1 1.2 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 KOS17829.1 - 3.4e-24 85.2 0.2 8.9e-24 83.9 0.1 1.8 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KOS17829.1 - 8.2e-12 45.6 0.3 3.1e-11 43.8 0.1 2.0 2 0 0 2 2 2 1 Aspartyl protease ubiquitin PF00240.23 KOS17829.1 - 9.6e-07 28.5 0.2 3e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family RVP_2 PF08284.11 KOS17829.1 - 0.0001 22.1 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 KOS17829.1 - 0.00022 21.5 0.0 0.00061 20.1 0.0 1.7 1 1 0 1 1 1 1 Retroviral aspartyl protease UN_NPL4 PF11543.8 KOS17829.1 - 0.025 15.1 0.0 0.058 13.9 0.0 1.6 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Ubiquitin_2 PF14560.6 KOS17829.1 - 0.16 12.5 0.1 0.41 11.1 0.1 1.7 1 1 0 1 1 1 0 Ubiquitin-like domain MRP-L47 PF06984.13 KOS17830.1 - 1.3e-21 76.5 0.2 2e-21 75.9 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) zf-H2C2_2 PF13465.6 KOS17831.1 - 8.3e-06 26.0 1.7 8.3e-06 26.0 1.7 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS17831.1 - 0.0058 17.4 15.7 0.41 11.6 1.8 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOS17831.1 - 0.4 11.0 5.4 9.7 6.6 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KOS17831.1 - 1.8 9.2 15.2 5.3 7.7 7.8 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type NOG1_N PF17835.1 KOS17832.1 - 3.3e-49 166.9 0.1 3.3e-49 166.9 0.1 2.3 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 KOS17832.1 - 8e-27 93.0 0.5 1.7e-26 91.9 0.5 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 KOS17832.1 - 4.8e-26 90.3 0.3 1.1e-25 89.2 0.3 1.6 1 0 0 1 1 1 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 KOS17832.1 - 5.4e-16 58.7 0.0 1.2e-15 57.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS17832.1 - 1.2e-07 31.3 0.0 2.2e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS17832.1 - 0.0034 17.5 0.6 2 8.5 0.0 2.9 2 1 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 KOS17832.1 - 0.0072 16.2 0.1 3.6 7.5 0.0 3.3 3 1 0 3 3 3 1 RsgA GTPase AAA_16 PF13191.6 KOS17832.1 - 0.054 13.9 5.3 0.26 11.7 0.0 3.8 3 1 1 4 4 4 0 AAA ATPase domain AAA_18 PF13238.6 KOS17832.1 - 0.13 12.9 0.3 3.4 8.2 0.0 3.0 3 0 0 3 3 3 0 AAA domain Roc PF08477.13 KOS17832.1 - 0.15 12.3 0.0 0.98 9.7 0.0 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase GDI PF00996.18 KOS17833.1 - 4.1e-185 615.4 0.0 4.7e-185 615.2 0.0 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor MoCF_biosynth PF00994.24 KOS17834.1 - 5e-24 84.6 0.0 8.5e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Probable molybdopterin binding domain 5_nucleotid_C PF02872.18 KOS17835.1 - 2.7e-35 121.9 0.0 4.4e-35 121.2 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 KOS17835.1 - 0.00045 20.8 0.2 0.0014 19.2 0.2 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Xpo1 PF08389.12 KOS17837.1 - 3.6e-27 95.3 3.3 1.3e-26 93.5 0.1 3.5 5 0 0 5 5 5 1 Exportin 1-like protein IBN_N PF03810.19 KOS17837.1 - 4.7e-07 29.6 0.1 3.8e-06 26.7 0.0 2.5 2 0 0 2 2 2 1 Importin-beta N-terminal domain Importin_rep_3 PF18806.1 KOS17837.1 - 0.00057 19.9 0.1 0.15 12.1 0.0 3.2 3 0 0 3 3 3 1 Importin 13 repeat UME PF08064.13 KOS17837.1 - 0.0057 16.5 6.8 5.3 7.0 0.0 5.2 4 1 1 5 5 5 1 UME (NUC010) domain FAM178 PF14816.6 KOS17837.1 - 0.031 13.2 0.0 0.11 11.4 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function, FAM178 Adaptin_N PF01602.20 KOS17837.1 - 0.074 11.6 1.1 4.1 5.8 0.0 3.0 2 1 1 3 3 3 0 Adaptin N terminal region Ras PF00071.22 KOS17838.1 - 8.1e-44 149.1 0.3 1e-43 148.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS17838.1 - 7.6e-11 42.3 0.0 1.3e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 KOS17838.1 - 3.9e-05 23.3 0.0 5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KOS17838.1 - 0.00036 20.0 0.1 0.00044 19.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 KOS17838.1 - 0.0032 17.4 0.0 0.0054 16.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain GATA PF00320.27 KOS17839.1 - 2.9 7.6 9.3 11 5.7 0.2 3.4 3 0 0 3 3 3 0 GATA zinc finger RIO1 PF01163.22 KOS17840.1 - 7.7e-41 139.8 0.1 4.6e-40 137.2 0.1 2.0 1 1 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 KOS17840.1 - 1.4e-22 79.7 0.0 2.9e-22 78.7 0.0 1.5 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 KOS17840.1 - 1.4e-08 35.0 0.3 6.5e-05 23.0 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOS17840.1 - 3.1e-07 29.9 0.1 1.2e-05 24.8 0.0 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CobT PF06213.12 KOS17840.1 - 0.067 12.6 11.8 0.097 12.0 11.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CENP-B_dimeris PF09026.10 KOS17840.1 - 0.081 13.3 15.4 0.15 12.4 15.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 KOS17840.1 - 0.14 12.2 8.7 0.27 11.2 8.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 KOS17840.1 - 0.2 9.7 17.5 0.27 9.3 17.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 KOS17840.1 - 0.23 10.8 15.0 0.32 10.3 15.0 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 KOS17840.1 - 0.25 10.4 16.9 0.34 10.0 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3245 PF11595.8 KOS17840.1 - 0.31 11.5 9.1 0.6 10.6 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) SGT1 PF07093.11 KOS17840.1 - 0.42 9.0 4.6 1.2 7.5 3.6 1.9 2 0 0 2 2 2 0 SGT1 protein FAM176 PF14851.6 KOS17840.1 - 0.68 9.6 5.6 1.2 8.8 5.6 1.4 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 KOS17840.1 - 0.76 9.5 14.6 1.2 8.8 14.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 KOS17840.1 - 0.92 9.3 7.4 1.8 8.3 7.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.10 KOS17840.1 - 2.8 8.2 6.7 4.5 7.6 6.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.12 KOS17840.1 - 3.3 5.8 17.0 4.4 5.4 17.0 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KOS17840.1 - 5.6 5.1 12.7 7.5 4.7 12.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 KOS17840.1 - 5.7 6.3 15.8 7.6 5.9 15.8 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 KOS17840.1 - 6.1 6.1 18.0 33 3.6 18.5 1.8 2 0 0 2 2 2 0 BUD22 PPP4R2 PF09184.11 KOS17840.1 - 6.1 6.3 11.2 9.4 5.7 11.2 1.2 1 0 0 1 1 1 0 PPP4R2 RRM_1 PF00076.22 KOS17841.1 - 1.2e-23 82.7 0.0 6e-12 45.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 5-FTHF_cyc-lig PF01812.20 KOS17842.1 - 6.1e-34 117.5 0.0 7.4e-34 117.2 0.0 1.1 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family RPN1_RPN2_N PF17781.1 KOS17843.1 - 9.7e-113 376.6 3.9 2.4e-112 375.3 4.1 1.5 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 KOS17843.1 - 4.1e-29 100.4 0.0 7.3e-29 99.6 0.0 1.4 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 KOS17843.1 - 1.9e-18 65.8 19.7 3.8e-07 30.2 0.3 8.1 8 1 0 8 8 8 4 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KOS17843.1 - 2.9e-07 30.8 0.3 0.068 13.6 0.0 4.2 5 1 1 6 6 6 2 HEAT repeats HEAT PF02985.22 KOS17843.1 - 0.0069 16.6 0.0 14 6.3 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat DUF812 PF05667.11 KOS17843.1 - 0.33 9.8 5.4 0.59 9.0 5.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) AAA_30 PF13604.6 KOS17844.1 - 0.009 15.7 0.0 0.018 14.8 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOS17844.1 - 0.01 15.6 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOS17845.1 - 1.4e-128 423.6 0.0 8.7e-22 77.6 0.0 9.5 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 KOS17845.1 - 3.1e-58 194.5 1.4 4.8e-22 78.2 0.0 5.4 5 0 0 5 5 5 3 Midasin AAA lid domain AAA_3 PF07726.11 KOS17845.1 - 1.9e-32 111.8 0.0 3.4e-09 36.6 0.0 7.6 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA_lid_5 PF17865.1 KOS17845.1 - 2.2e-32 111.3 0.1 5.2e-31 106.9 0.1 3.3 4 0 0 4 4 2 1 Midasin AAA lid domain AAA_16 PF13191.6 KOS17845.1 - 6.6e-30 104.7 10.8 3.5e-07 30.8 1.0 7.9 6 1 0 6 6 6 5 AAA ATPase domain AAA PF00004.29 KOS17845.1 - 1.7e-29 102.9 0.0 0.00047 20.6 0.0 7.1 6 0 0 6 6 6 5 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOS17845.1 - 2.2e-28 99.0 2.6 4.1e-06 26.4 0.0 7.1 7 0 0 7 7 7 5 P-loop containing dynein motor region Dynein_heavy PF03028.15 KOS17845.1 - 6.2e-28 97.3 0.0 0.00046 20.3 0.0 8.4 9 0 0 9 9 7 4 Dynein heavy chain region D6 P-loop domain AAA_22 PF13401.6 KOS17845.1 - 1.7e-21 77.0 0.1 0.0035 17.6 0.0 7.5 6 0 0 6 6 6 4 AAA domain Sigma54_activat PF00158.26 KOS17845.1 - 9.3e-20 71.0 0.0 0.0047 16.6 0.1 6.2 6 0 0 6 6 6 4 Sigma-54 interaction domain AAA_6 PF12774.7 KOS17845.1 - 6.1e-19 68.2 0.1 0.0028 16.7 0.0 8.2 7 1 0 7 7 7 3 Hydrolytic ATP binding site of dynein motor region AAA_18 PF13238.6 KOS17845.1 - 7.5e-18 65.3 0.2 0.052 14.1 0.0 6.8 7 0 0 7 7 5 3 AAA domain TsaE PF02367.17 KOS17845.1 - 1.1e-17 64.1 2.8 0.0014 18.7 0.1 5.5 5 0 0 5 5 5 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOS17845.1 - 1.6e-16 60.7 0.0 0.0025 18.0 0.0 6.6 7 0 0 7 7 5 2 AAA domain AAA_14 PF13173.6 KOS17845.1 - 5.7e-16 58.8 0.0 0.0096 16.0 0.0 6.8 6 1 0 6 6 6 2 AAA domain AAA_30 PF13604.6 KOS17845.1 - 6.5e-16 58.6 0.0 0.0005 19.8 0.0 7.0 8 0 0 8 8 6 2 AAA domain RsgA_GTPase PF03193.16 KOS17845.1 - 5.2e-15 55.8 1.1 0.057 13.3 0.0 6.0 6 0 0 6 6 6 3 RsgA GTPase RuvB_N PF05496.12 KOS17845.1 - 3.9e-14 52.7 2.7 0.039 13.7 0.0 6.5 6 0 0 6 6 6 3 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 KOS17845.1 - 7.9e-14 51.9 0.7 0.11 13.0 0.0 6.4 6 0 0 6 6 6 3 RNA helicase Sigma54_activ_2 PF14532.6 KOS17845.1 - 1.1e-13 51.4 0.6 0.0016 18.6 0.0 5.5 6 0 0 6 6 4 2 Sigma-54 interaction domain ABC_tran PF00005.27 KOS17845.1 - 1.5e-13 51.5 2.4 0.0015 19.1 0.0 7.0 6 1 0 6 6 6 2 ABC transporter NACHT PF05729.12 KOS17845.1 - 2.4e-13 50.4 1.1 0.06 13.3 0.1 5.8 6 0 0 6 6 5 3 NACHT domain T2SSE PF00437.20 KOS17845.1 - 3e-12 46.2 1.0 0.0052 15.9 0.0 5.2 6 0 0 6 6 5 3 Type II/IV secretion system protein IstB_IS21 PF01695.17 KOS17845.1 - 6.5e-12 45.5 0.1 0.062 13.0 0.0 5.9 6 0 0 6 6 6 2 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOS17845.1 - 6.1e-11 42.1 1.5 3.6 6.9 0.0 8.1 8 0 0 8 8 7 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 KOS17845.1 - 2.2e-10 40.1 4.6 0.15 11.3 0.0 6.1 6 0 0 6 6 5 2 Zeta toxin Rad17 PF03215.15 KOS17845.1 - 5.3e-10 39.5 0.9 0.14 12.1 0.0 5.8 6 0 0 6 6 5 2 Rad17 P-loop domain AAA_28 PF13521.6 KOS17845.1 - 5.9e-10 39.6 1.2 3.3 7.9 0.0 6.0 5 0 0 5 5 5 0 AAA domain AAA_25 PF13481.6 KOS17845.1 - 6.5e-10 38.9 0.5 0.15 11.6 0.0 5.7 5 0 0 5 5 5 1 AAA domain DUF815 PF05673.13 KOS17845.1 - 5.7e-09 35.5 1.0 0.27 10.4 0.0 5.1 5 0 0 5 5 5 2 Protein of unknown function (DUF815) AAA_19 PF13245.6 KOS17845.1 - 2.6e-08 34.3 6.0 0.69 10.2 0.1 5.9 6 1 0 6 6 4 1 AAA domain NTPase_1 PF03266.15 KOS17845.1 - 2.7e-08 33.9 3.6 0.53 10.2 0.1 5.2 6 0 0 6 6 4 2 NTPase ATPase_2 PF01637.18 KOS17845.1 - 2.8e-08 34.0 0.0 2.3 8.1 0.0 5.6 5 0 0 5 5 5 0 ATPase domain predominantly from Archaea TniB PF05621.11 KOS17845.1 - 9.7e-08 31.6 1.4 2.2 7.7 0.0 6.3 8 0 0 8 8 5 0 Bacterial TniB protein dNK PF01712.19 KOS17845.1 - 2.1e-07 31.0 2.2 13 5.6 0.0 5.4 5 0 0 5 5 5 0 Deoxynucleoside kinase AAA_29 PF13555.6 KOS17845.1 - 2.2e-07 30.5 0.0 6.6 6.6 0.0 6.1 6 0 0 6 6 5 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 KOS17845.1 - 2.4e-07 30.8 0.7 17 5.5 0.0 5.5 5 0 0 5 5 5 0 50S ribosome-binding GTPase TIP49 PF06068.13 KOS17845.1 - 2.9e-07 30.0 0.3 0.21 10.8 0.0 4.8 5 0 0 5 5 5 1 TIP49 P-loop domain AAA_2 PF07724.14 KOS17845.1 - 3e-07 30.7 0.0 3.1 7.9 0.0 5.9 5 0 0 5 5 5 0 AAA domain (Cdc48 subfamily) SRP54 PF00448.22 KOS17845.1 - 5e-07 29.5 4.5 0.36 10.4 0.1 5.0 6 0 0 6 6 5 2 SRP54-type protein, GTPase domain Roc PF08477.13 KOS17845.1 - 6.9e-07 29.5 1.9 3.3 7.9 0.0 5.4 5 0 0 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 KOS17845.1 - 8e-07 28.9 2.0 0.23 11.2 0.0 4.8 5 0 0 5 5 5 2 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 KOS17845.1 - 8e-07 29.8 0.0 1.7 9.1 0.0 4.9 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 KOS17845.1 - 1.1e-06 28.6 1.2 2 8.1 0.2 6.1 6 1 0 6 6 5 1 AAA domain ResIII PF04851.15 KOS17845.1 - 1.6e-06 28.3 0.3 0.93 9.5 0.0 4.9 5 0 0 5 5 5 2 Type III restriction enzyme, res subunit AAA_11 PF13086.6 KOS17845.1 - 5.4e-06 26.4 2.6 1.4 8.7 0.1 5.3 5 0 0 5 5 5 1 AAA domain Bac_DnaA PF00308.18 KOS17845.1 - 1.2e-05 25.3 1.3 13 5.5 0.0 5.1 6 0 0 6 6 4 0 Bacterial dnaA protein Viral_helicase1 PF01443.18 KOS17845.1 - 2.9e-05 23.9 0.1 8.6 6.0 0.0 5.2 5 0 0 5 5 5 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 KOS17845.1 - 3.5e-05 23.1 1.3 1.9 7.6 0.0 4.6 4 0 0 4 4 4 1 NB-ARC domain AAA_9 PF12781.7 KOS17845.1 - 0.00014 21.1 0.0 0.79 8.8 0.0 5.2 6 0 0 6 6 5 1 ATP-binding dynein motor region SRPRB PF09439.10 KOS17845.1 - 0.00026 20.5 0.9 6.4 6.2 0.0 5.0 5 0 0 5 5 5 0 Signal recognition particle receptor beta subunit KAP_NTPase PF07693.14 KOS17845.1 - 0.00032 20.0 0.0 2.8 7.1 0.0 4.8 5 0 0 5 5 5 0 KAP family P-loop domain ATP_bind_1 PF03029.17 KOS17845.1 - 0.00033 20.5 3.3 12 5.5 0.0 4.8 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein CbiA PF01656.23 KOS17845.1 - 0.00073 19.6 0.1 57 3.8 0.0 5.2 5 0 0 5 5 5 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_17 PF13207.6 KOS17845.1 - 0.0009 19.7 2.1 18 5.7 0.1 4.6 4 0 0 4 4 4 0 AAA domain DnaB_C PF03796.15 KOS17845.1 - 0.0012 18.2 0.2 0.85 8.9 0.0 4.0 5 0 0 5 5 4 1 DnaB-like helicase C terminal domain cobW PF02492.19 KOS17845.1 - 0.0012 18.5 5.9 16 5.0 0.1 5.5 6 0 0 6 6 5 0 CobW/HypB/UreG, nucleotide-binding domain CPT PF07931.12 KOS17845.1 - 0.0017 18.3 1.8 17 5.2 0.0 5.7 7 1 0 7 7 4 0 Chloramphenicol phosphotransferase-like protein DUF853 PF05872.12 KOS17845.1 - 0.002 16.8 0.4 0.53 8.8 0.1 2.4 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF853) DEAD PF00270.29 KOS17845.1 - 0.002 17.9 0.1 3.6 7.3 0.0 3.8 4 0 0 4 4 3 0 DEAD/DEAH box helicase Thymidylate_kin PF02223.17 KOS17845.1 - 0.0023 17.7 7.0 3.1 7.4 0.0 5.7 7 1 1 8 8 5 0 Thymidylate kinase PhoH PF02562.16 KOS17845.1 - 0.0024 17.4 0.4 5.7 6.3 0.0 4.3 4 0 0 4 4 4 0 PhoH-like protein MeaB PF03308.16 KOS17845.1 - 0.0041 16.1 3.1 1.3 8.0 0.1 3.9 4 0 0 4 4 4 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SKI PF01202.22 KOS17845.1 - 0.0048 17.0 0.5 17 5.5 0.0 4.3 4 0 0 4 4 4 0 Shikimate kinase Septin PF00735.18 KOS17845.1 - 0.0066 15.8 1.8 5.7 6.1 0.0 3.8 5 0 0 5 5 4 0 Septin ATPase PF06745.13 KOS17845.1 - 0.012 15.0 0.1 9.3 5.5 0.0 3.8 4 0 0 4 4 4 0 KaiC DAP3 PF10236.9 KOS17845.1 - 0.014 14.6 7.0 3.1 6.9 0.0 4.5 5 0 0 5 5 4 0 Mitochondrial ribosomal death-associated protein 3 GAF_2 PF13185.6 KOS17845.1 - 0.017 15.4 0.0 2.8 8.2 0.0 3.9 3 0 0 3 3 2 0 GAF domain KTI12 PF08433.10 KOS17845.1 - 0.018 14.5 0.0 11 5.3 0.0 4.1 4 0 0 4 4 4 0 Chromatin associated protein KTI12 IPT PF01745.16 KOS17845.1 - 0.02 14.3 0.2 8 5.8 0.0 3.7 4 0 0 4 4 4 0 Isopentenyl transferase TrwB_AAD_bind PF10412.9 KOS17845.1 - 0.03 13.2 1.1 19 4.0 0.0 4.0 4 0 0 4 4 4 0 Type IV secretion-system coupling protein DNA-binding domain ATP-synt_ab PF00006.25 KOS17845.1 - 0.034 13.8 0.0 13 5.4 0.0 3.4 4 1 0 4 4 3 0 ATP synthase alpha/beta family, nucleotide-binding domain PRK PF00485.18 KOS17845.1 - 0.061 13.1 0.1 14 5.3 0.0 3.4 3 0 0 3 3 3 0 Phosphoribulokinase / Uridine kinase family Y_phosphatase PF00102.27 KOS17845.1 - 0.063 12.8 0.0 8 5.9 0.0 3.5 4 0 0 4 4 3 0 Protein-tyrosine phosphatase AAA_8 PF12780.7 KOS17845.1 - 0.064 12.6 0.5 2.9 7.1 0.0 3.6 5 0 0 5 5 2 0 P-loop containing dynein motor region D4 Ras PF00071.22 KOS17845.1 - 0.066 12.8 1.7 51 3.4 0.1 4.2 5 0 0 5 5 4 0 Ras family FtsK_SpoIIIE PF01580.18 KOS17845.1 - 0.075 12.4 0.6 17 4.7 0.0 3.3 4 0 0 4 4 2 0 FtsK/SpoIIIE family APS_kinase PF01583.20 KOS17845.1 - 0.1 12.5 0.2 1.1e+02 2.6 0.0 4.4 5 0 0 5 5 4 0 Adenylylsulphate kinase G-alpha PF00503.20 KOS17845.1 - 0.11 11.7 0.1 5.9 5.9 0.0 2.7 3 0 0 3 3 2 0 G-protein alpha subunit AAA_15 PF13175.6 KOS17845.1 - 0.12 12.1 0.1 13 5.3 0.0 3.0 3 0 0 3 3 3 0 AAA ATPase domain MobB PF03205.14 KOS17845.1 - 0.13 12.2 4.5 29 4.6 0.1 4.4 5 0 0 5 5 4 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 KOS17845.1 - 0.15 11.6 1.6 79 2.7 0.0 4.2 5 0 0 5 5 4 0 Ferrous iron transport protein B DUF87 PF01935.17 KOS17845.1 - 0.18 11.9 7.0 11 6.1 0.0 4.0 3 1 0 3 3 2 0 Helicase HerA, central domain Hpr_kinase_C PF07475.12 KOS17845.1 - 0.26 10.8 4.1 1.3 8.5 0.2 3.5 4 0 0 4 4 4 0 HPr Serine kinase C-terminal domain Ribosomal_L12 PF00542.19 KOS17846.1 - 4e-20 71.9 7.2 3e-19 69.1 4.8 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 KOS17846.1 - 1.2e-08 34.6 17.1 1.2e-08 34.6 17.1 4.0 3 1 0 3 3 3 1 Ribosomal protein L7/L12 dimerisation domain SpoVIF PF14069.6 KOS17846.1 - 0.06 13.1 0.9 0.13 12.1 0.2 1.9 2 1 0 2 2 2 0 Stage VI sporulation protein F CTK3 PF12243.8 KOS17847.1 - 3e-48 162.9 0.1 4.4e-48 162.4 0.1 1.2 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 CTK3_C PF12350.8 KOS17847.1 - 7e-19 67.8 9.9 7e-19 67.8 9.9 1.9 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 C-terminus Lipase_GDSL PF00657.22 KOS17848.1 - 2.8e-10 40.5 0.0 3.5e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Lipase_GDSL_2 PF13472.6 KOS17848.1 - 4.2e-09 37.1 0.0 6.5e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Isochorismatase PF00857.20 KOS17850.1 - 6.2e-19 68.8 0.0 1.9e-18 67.2 0.0 1.7 1 1 0 1 1 1 1 Isochorismatase family VWA PF00092.28 KOS17851.1 - 0.0004 20.7 0.1 0.002 18.4 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOS17851.1 - 0.013 16.1 0.0 0.05 14.3 0.0 2.1 1 0 0 1 1 1 0 von Willebrand factor type A domain Hat1_N PF10394.9 KOS17852.1 - 6.9e-36 123.9 0.0 1.1e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus LMBR1 PF04791.16 KOS17853.1 - 2.1e-102 343.7 1.2 2.4e-102 343.5 1.2 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Caskin-Pro-rich PF16907.5 KOS17853.1 - 0.0054 17.2 1.0 0.0054 17.2 1.0 2.3 2 1 1 3 3 3 1 Proline rich region of Caskin proteins Mpv17_PMP22 PF04117.12 KOS17854.1 - 2.2e-16 59.8 0.2 2.2e-16 59.8 0.2 2.1 2 0 0 2 2 2 1 Mpv17 / PMP22 family ENOD93 PF03386.14 KOS17854.1 - 0.27 11.2 1.3 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 Early nodulin 93 ENOD93 protein p450 PF00067.22 KOS17855.1 - 2.3e-46 158.5 0.0 1.2e-27 96.8 0.0 2.1 2 0 0 2 2 2 2 Cytochrome P450 DUF802 PF05650.11 KOS17855.1 - 0.23 11.9 1.4 0.45 11.0 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF802) Ank_4 PF13637.6 KOS17856.1 - 1.2e-08 35.3 0.5 4.7e-05 23.9 0.0 4.3 2 2 3 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 KOS17856.1 - 3.2e-08 33.6 1.7 0.42 11.1 0.1 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 KOS17856.1 - 6.2e-08 32.3 0.5 0.33 11.7 0.0 5.1 5 1 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.7 KOS17856.1 - 1.7e-07 31.7 0.0 0.0071 16.9 0.0 3.1 2 2 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOS17856.1 - 1.5e-06 28.3 1.5 0.063 13.6 0.1 3.8 3 1 0 3 3 3 2 Ankyrin repeats (many copies) F-box PF00646.33 KOS17856.1 - 0.0021 17.9 0.1 0.0038 17.1 0.1 1.4 1 0 0 1 1 1 1 F-box domain DUF1376 PF07120.11 KOS17856.1 - 0.0036 17.6 0.0 0.0075 16.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1376) F-box-like PF12937.7 KOS17856.1 - 0.027 14.4 0.2 0.054 13.4 0.2 1.5 1 0 0 1 1 1 0 F-box-like PRANC PF09372.10 KOS17856.1 - 0.17 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 PRANC domain JAB PF01398.21 KOS17857.1 - 3.5e-32 110.9 0.0 6.2e-32 110.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KOS17857.1 - 1.5e-11 44.7 0.5 3.2e-11 43.6 0.5 1.6 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 KOS17857.1 - 4.8e-07 29.6 0.0 9.8e-07 28.6 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain RNA_pol_Rpc34 PF05158.12 KOS17858.1 - 3.8e-101 338.8 0.0 6.1e-101 338.2 0.0 1.3 1 1 0 1 1 1 1 RNA polymerase Rpc34 subunit RPA_C PF08784.11 KOS17858.1 - 0.0001 22.9 1.2 0.0039 17.8 0.0 3.2 3 1 1 4 4 4 1 Replication protein A C terminal B-block_TFIIIC PF04182.12 KOS17858.1 - 0.018 15.2 0.1 0.046 13.9 0.0 1.7 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC Ribosomal_S25 PF03297.15 KOS17858.1 - 0.02 15.1 0.1 0.02 15.1 0.1 2.0 2 0 0 2 2 2 0 S25 ribosomal protein HTH_36 PF13730.6 KOS17858.1 - 0.035 14.1 0.2 0.78 9.7 0.1 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain MAGE_N PF12440.8 KOS17858.1 - 0.036 14.7 2.9 0.085 13.5 2.9 1.6 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal MarR PF01047.22 KOS17858.1 - 0.054 13.4 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 MarR family RTBV_P12 PF06361.11 KOS17858.1 - 0.078 13.4 0.1 0.37 11.2 0.1 2.0 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Mnd1 PF03962.15 KOS17858.1 - 0.14 12.5 0.2 17 5.8 0.0 2.8 2 0 0 2 2 2 0 Mnd1 HTH domain Pro_isomerase PF00160.21 KOS17859.1 - 2e-45 154.9 0.2 2.3e-45 154.7 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ENTH PF01417.20 KOS17860.1 - 2.4e-46 156.9 0.2 3.5e-46 156.3 0.2 1.3 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 KOS17860.1 - 0.0011 18.1 0.0 0.0016 17.5 0.0 1.2 1 0 0 1 1 1 1 ANTH domain DSS1_SEM1 PF05160.13 KOS17860.1 - 0.051 13.7 1.8 1.6 8.8 0.1 2.4 2 0 0 2 2 2 0 DSS1/SEM1 family DUF5102 PF17104.5 KOS17860.1 - 2.1 8.3 12.5 2.6 8.0 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5102) AAA PF00004.29 KOS17861.1 - 1.7e-50 170.9 0.0 4.2e-42 143.7 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS17861.1 - 1.6e-09 37.4 0.2 7e-09 35.3 0.0 2.2 2 0 0 2 2 1 1 AAA+ lid domain IstB_IS21 PF01695.17 KOS17861.1 - 3.3e-07 30.2 0.0 9.6e-06 25.4 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 KOS17861.1 - 4e-07 30.6 0.2 0.00029 21.3 0.2 3.4 2 2 0 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 KOS17861.1 - 1.3e-05 25.4 0.0 3.5e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOS17861.1 - 0.00067 19.7 0.0 0.0027 17.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOS17861.1 - 0.0015 18.7 0.1 0.031 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOS17861.1 - 0.0029 18.0 0.0 0.0094 16.3 0.0 1.9 1 0 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 KOS17861.1 - 0.0034 17.9 0.0 0.2 12.2 0.0 3.1 2 1 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 KOS17861.1 - 0.0034 17.9 0.2 0.034 14.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS17861.1 - 0.0034 17.7 1.0 0.058 13.7 0.2 2.8 2 1 0 2 2 1 1 AAA domain TIP49 PF06068.13 KOS17861.1 - 0.0099 15.1 0.0 0.019 14.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 KOS17861.1 - 0.012 15.4 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Sigma54_activ_2 PF14532.6 KOS17861.1 - 0.022 14.9 0.0 1.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_14 PF13173.6 KOS17861.1 - 0.031 14.3 0.0 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOS17861.1 - 0.051 12.9 0.1 0.12 11.7 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOS17861.1 - 0.07 13.4 0.0 0.28 11.4 0.0 2.1 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 KOS17861.1 - 0.073 12.8 0.0 2.2 8.0 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Bromodomain PF00439.25 KOS17861.1 - 0.084 13.0 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 Bromodomain Parvo_NS1 PF01057.17 KOS17861.1 - 0.085 11.9 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 KOS17861.1 - 0.093 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOS17861.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 KOS17861.1 - 0.11 12.4 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 1 0 NACHT domain AAA_11 PF13086.6 KOS17861.1 - 0.62 9.8 0.0 0.62 9.8 0.0 4.4 5 1 0 5 5 4 0 AAA domain RIBIOP_C PF04950.12 KOS17863.1 - 4.5e-93 311.9 3.5 2.9e-92 309.2 0.0 2.5 2 0 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KOS17863.1 - 1.5e-27 95.5 0.0 5.2e-27 93.8 0.0 2.1 1 0 0 1 1 1 1 AARP2CN (NUC121) domain AAA_16 PF13191.6 KOS17863.1 - 5.1e-05 23.7 0.2 0.00027 21.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 KOS17863.1 - 0.0002 21.9 0.1 0.0016 19.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 KOS17863.1 - 0.00021 21.5 0.1 0.00072 19.8 0.0 1.9 2 0 0 2 2 1 1 AAA domain GTP_EFTU PF00009.27 KOS17863.1 - 0.00082 19.0 0.0 0.15 11.6 0.0 2.5 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS17863.1 - 0.00089 19.3 0.0 0.003 17.6 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 KOS17863.1 - 0.0011 19.1 0.0 0.0044 17.2 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 KOS17863.1 - 0.0014 19.1 0.0 0.0032 17.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOS17863.1 - 0.0016 18.4 0.0 0.0033 17.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOS17863.1 - 0.003 17.9 0.0 0.0078 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 KOS17863.1 - 0.0049 16.1 0.0 0.0098 15.1 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_30 PF13604.6 KOS17863.1 - 0.011 15.5 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KOS17863.1 - 0.016 15.0 0.0 0.056 13.2 0.0 1.8 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 KOS17863.1 - 0.026 14.9 0.0 0.06 13.7 0.0 1.6 1 0 0 1 1 1 0 RNA helicase cobW PF02492.19 KOS17863.1 - 0.027 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 KOS17863.1 - 0.034 14.2 0.0 0.11 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOS17863.1 - 0.044 13.7 0.0 0.15 11.9 0.0 1.9 1 1 1 2 2 1 0 RsgA GTPase AAA_25 PF13481.6 KOS17863.1 - 0.048 13.2 0.0 0.13 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 KOS17863.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 NTPase_1 PF03266.15 KOS17863.1 - 0.05 13.5 0.1 0.099 12.5 0.1 1.5 1 0 0 1 1 1 0 NTPase Rad17 PF03215.15 KOS17863.1 - 0.057 13.3 0.2 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_7 PF12775.7 KOS17863.1 - 0.085 12.4 0.0 0.23 11.0 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 KOS17863.1 - 0.1 12.9 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_5 PF07728.14 KOS17863.1 - 0.11 12.5 0.1 0.33 11.0 0.0 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) MobB PF03205.14 KOS17863.1 - 0.13 12.2 0.2 1.2 9.0 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ATPase_2 PF01637.18 KOS17863.1 - 0.15 11.9 0.0 0.15 11.9 0.0 2.1 3 0 0 3 3 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KOS17863.1 - 0.23 12.0 0.0 0.23 12.0 0.0 4.7 6 0 0 6 6 4 0 AAA domain AAA_11 PF13086.6 KOS17863.1 - 0.3 10.8 0.0 0.3 10.8 0.0 4.1 3 1 0 3 3 2 0 AAA domain DUF4692 PF15763.5 KOS17864.1 - 0.22 12.0 4.1 1.2 9.6 1.9 2.3 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Eaf7 PF07904.13 KOS17865.1 - 1.3e-25 89.8 0.1 1.3e-25 89.8 0.1 2.0 2 0 0 2 2 2 1 Chromatin modification-related protein EAF7 PPP4R2 PF09184.11 KOS17865.1 - 0.51 9.9 10.7 0.62 9.6 10.7 1.2 1 0 0 1 1 1 0 PPP4R2 CDC27 PF09507.10 KOS17865.1 - 0.91 8.8 9.9 1.2 8.4 9.9 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 KOS17865.1 - 1 7.5 9.8 1.4 7.1 9.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOS17865.1 - 5.8 6.1 11.5 10 5.3 11.5 1.3 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 KOS17865.1 - 6.1 5.0 6.4 8 4.6 6.4 1.2 1 0 0 1 1 1 0 CDC45-like protein GCP_C_terminal PF04130.13 KOS17866.1 - 3.4e-78 263.2 0.2 9.3e-78 261.8 0.0 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KOS17866.1 - 2.6e-24 86.4 0.0 4.3e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal DASH_Ask1 PF08655.10 KOS17867.1 - 2.3e-30 104.3 0.2 3.4e-30 103.7 0.2 1.3 1 0 0 1 1 1 1 DASH complex subunit Ask1 Cbl_N2 PF02761.14 KOS17867.1 - 0.067 13.9 0.9 0.12 13.1 0.2 1.7 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Cwf_Cwc_15 PF04889.12 KOS17867.1 - 0.54 10.0 13.6 1.1 9.0 13.6 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Defensin_propep PF00879.18 KOS17867.1 - 1.2 9.4 9.8 2.5 8.4 0.5 3.2 2 1 0 2 2 2 0 Defensin propeptide SUIM_assoc PF16619.5 KOS17869.1 - 0.0059 16.7 1.3 0.0059 16.7 1.3 1.6 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Retinal PF15449.6 KOS17869.1 - 0.063 11.1 2.0 0.082 10.7 2.0 1.1 1 0 0 1 1 1 0 Retinal protein KH_1 PF00013.29 KOS17870.1 - 4e-31 106.6 0.7 2.6e-07 30.3 0.0 6.9 7 0 0 7 7 7 6 KH domain ResIII PF04851.15 KOS17871.1 - 1.5e-23 83.7 0.0 2.8e-23 82.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOS17871.1 - 1.1e-15 57.9 0.1 4.3e-14 52.8 0.0 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS17871.1 - 9.8e-12 45.0 0.0 2e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 KOS17871.1 - 0.00037 20.2 0.0 0.00074 19.2 0.0 1.4 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 KOS17871.1 - 0.0059 15.9 0.0 0.0099 15.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) ERCC3_RAD25_C PF16203.5 KOS17871.1 - 0.0077 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 KOS17871.1 - 0.031 14.0 0.0 0.13 11.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain DUF3072 PF11272.8 KOS17871.1 - 0.12 12.3 0.0 0.37 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3072) Septin PF00735.18 KOS17873.1 - 1.1e-28 100.4 0.1 1.1e-08 34.7 0.0 3.1 3 0 0 3 3 3 3 Septin G-alpha PF00503.20 KOS17873.1 - 0.0061 15.8 0.1 0.014 14.5 0.0 1.6 2 0 0 2 2 2 1 G-protein alpha subunit AAA_23 PF13476.6 KOS17873.1 - 0.013 16.0 0.1 0.044 14.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 KOS17873.1 - 0.17 11.2 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family COA2 PF17051.5 KOS17874.1 - 1.8e-05 24.7 1.0 3.3e-05 23.8 1.0 1.5 1 1 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 DUF4240 PF14024.6 KOS17874.1 - 0.016 15.4 0.6 0.022 14.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4240) Spt20 PF12090.8 KOS17874.1 - 0.23 11.1 5.8 0.25 11.0 5.8 1.1 1 0 0 1 1 1 0 Spt20 family DUF1980 PF09323.10 KOS17874.1 - 0.23 11.3 0.0 0.29 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Metallophos PF00149.28 KOS17875.1 - 3.8e-31 109.2 0.0 5.5e-22 79.3 0.0 2.1 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOS17875.1 - 0.13 12.7 0.1 0.38 11.2 0.1 1.8 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Methyltransf_25 PF13649.6 KOS17876.1 - 1.5e-07 32.0 0.0 4.1e-07 30.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS17876.1 - 1.1e-06 28.5 0.0 0.00031 20.6 0.0 2.4 1 1 1 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 KOS17876.1 - 3.9e-06 26.7 0.0 7.1e-05 22.6 0.0 2.2 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOS17876.1 - 0.00011 21.9 0.0 0.00029 20.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase small domain FtsJ PF01728.19 KOS17876.1 - 0.0002 21.6 0.0 0.00051 20.2 0.0 1.7 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_11 PF08241.12 KOS17876.1 - 0.00023 21.8 0.0 0.0015 19.1 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS17876.1 - 0.00053 20.7 0.0 0.0064 17.2 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOS17876.1 - 0.0032 17.0 0.0 0.0055 16.2 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 KOS17876.1 - 0.027 13.8 0.0 0.053 12.8 0.0 1.5 1 0 0 1 1 1 0 O-methyltransferase domain Ubie_methyltran PF01209.18 KOS17876.1 - 0.045 13.1 0.0 0.18 11.1 0.0 1.9 3 0 0 3 3 3 0 ubiE/COQ5 methyltransferase family UPF0146 PF03686.13 KOS17876.1 - 0.047 13.6 0.0 0.075 12.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) Methyltransf_16 PF10294.9 KOS17876.1 - 0.15 11.8 0.0 0.21 11.3 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase CDC45 PF02724.14 KOS17877.1 - 1.4e-251 836.3 0.0 1.5e-250 833.0 0.0 2.8 1 1 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 KOS17877.1 - 0.26 11.0 28.9 0.021 14.6 11.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 KOS17877.1 - 0.28 10.5 28.0 0.94 8.7 16.1 2.1 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 KOS17877.1 - 0.34 10.3 19.8 0.8 9.1 10.0 2.2 2 0 0 2 2 2 0 SDA1 FAM60A PF15396.6 KOS17877.1 - 0.45 10.5 6.0 0.076 13.0 1.4 1.9 2 0 0 2 2 2 0 Protein Family FAM60A SMN PF06003.12 KOS17877.1 - 1.2 8.3 9.7 0.038 13.2 1.1 2.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) TFIIF_alpha PF05793.12 KOS17877.1 - 5.3 5.5 26.8 4.7 5.7 4.6 2.1 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDP-OH_P_transf PF01066.21 KOS17878.1 - 9.8e-15 55.1 0.1 9.8e-15 55.1 0.1 3.8 3 1 0 3 3 3 1 CDP-alcohol phosphatidyltransferase JAB PF01398.21 KOS17879.1 - 5e-10 39.4 0.0 8.7e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 KOS17879.1 - 2.4e-07 31.1 0.0 5.4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function ABC1 PF03109.16 KOS17880.1 - 4.7e-21 75.2 0.0 8.5e-21 74.3 0.0 1.4 1 0 0 1 1 1 1 ABC1 family APH PF01636.23 KOS17880.1 - 1.6e-05 24.9 0.0 3.9e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Orbi_VP2 PF00898.17 KOS17880.1 - 0.11 10.2 0.0 0.16 9.7 0.0 1.1 1 0 0 1 1 1 0 Orbivirus outer capsid protein VP2 DcpS_C PF11969.8 KOS17882.1 - 3.8e-31 107.9 0.0 5.7e-31 107.3 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 KOS17882.1 - 2e-27 96.0 0.0 3.3e-27 95.4 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DUF2016 PF09436.10 KOS17882.1 - 0.074 12.9 0.1 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2016) Abhydrolase_1 PF00561.20 KOS17883.1 - 2.6e-19 69.9 0.1 8.4e-17 61.7 0.1 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 KOS17883.1 - 2.5e-14 53.2 0.0 7.4e-14 51.7 0.0 1.8 2 0 0 2 2 2 1 TAP-like protein Ribophorin_II PF05817.14 KOS17884.1 - 0.16 10.5 0.0 0.29 9.6 0.0 1.3 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II SGL PF08450.12 KOS17885.1 - 0.013 15.1 0.0 0.015 14.9 0.0 1.4 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region DUF1275 PF06912.11 KOS17886.1 - 1.8e-45 155.2 17.8 2.2e-45 155.0 17.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1275) FAM199X PF15814.5 KOS17887.1 - 2.3 7.2 13.8 3.4 6.6 13.8 1.2 1 0 0 1 1 1 0 Protein family FAM199X Sporozoite_P67 PF05642.11 KOS17887.1 - 9.9 4.1 11.8 12 3.8 11.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 KOS17888.1 - 3.5e-72 243.0 0.0 5.7e-72 242.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17888.1 - 7.8e-36 123.7 0.0 2.2e-35 122.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17888.1 - 0.00095 18.6 0.1 0.66 9.2 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 KOS17888.1 - 0.0076 15.1 0.2 0.0076 15.1 0.2 1.9 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 KOS17888.1 - 0.14 12.1 8.0 0.11 12.4 0.9 3.3 2 1 0 2 2 2 0 Phosphotransferase enzyme family Orthopox_F8 PF05886.11 KOS17888.1 - 0.18 12.0 2.1 0.69 10.1 2.1 2.0 1 0 0 1 1 1 0 Orthopoxvirus F8 protein Pkinase PF00069.25 KOS17889.1 - 1.2e-34 119.9 0.0 2e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17889.1 - 1.9e-18 66.7 0.0 9.9e-18 64.3 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17889.1 - 3.2e-05 23.4 0.0 5.5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS17889.1 - 0.02 14.8 0.0 0.058 13.3 0.0 1.7 1 1 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOS17889.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 KOS17889.1 - 0.2 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 ABC1 family Nop25 PF09805.9 KOS17890.1 - 6.2e-43 146.5 17.9 6.2e-43 146.5 17.9 1.8 2 0 0 2 2 2 1 Nucleolar protein 12 (25kDa) DUF3292 PF11696.8 KOS17890.1 - 0.12 10.7 3.9 0.22 9.9 3.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) UCMA PF17085.5 KOS17890.1 - 0.5 10.4 10.0 0.95 9.5 10.0 1.6 1 0 0 1 1 1 0 Unique cartilage matrix associated protein Ribosomal_L37 PF08561.10 KOS17890.1 - 5.2 7.6 9.0 3.2 8.3 6.9 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L37 RhlB PF12300.8 KOS17891.1 - 0.19 11.9 6.8 0.27 11.3 6.8 1.2 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB ATP-synt_S1 PF05827.12 KOS17892.1 - 0.00049 19.9 0.0 0.00091 19.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar ATP synthase subunit S1 (ATP6S1) GPHR_N PF12537.8 KOS17892.1 - 0.32 11.1 0.2 0.32 11.1 0.2 1.9 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal bZIP_1 PF00170.21 KOS17893.1 - 2.5e-08 33.9 8.9 4.6e-08 33.0 8.9 1.4 1 0 0 1 1 1 1 bZIP transcription factor dsrm PF00035.26 KOS17893.1 - 0.098 13.4 0.4 0.23 12.2 0.4 1.6 1 0 0 1 1 1 0 Double-stranded RNA binding motif Ribosomal_L30_N PF08079.12 KOS17893.1 - 0.11 12.7 10.1 0.24 11.7 10.1 1.5 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Uds1 PF15456.6 KOS17893.1 - 7.4 6.8 9.7 0.73 10.0 5.1 1.5 2 0 0 2 2 2 0 Up-regulated During Septation Atrophin-1 PF03154.15 KOS17896.1 - 0.0014 17.0 15.4 0.0014 17.0 15.4 2.1 1 1 1 2 2 2 1 Atrophin-1 family DUF3915 PF13054.6 KOS17896.1 - 0.015 15.3 8.1 0.027 14.4 8.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) RSB_motif PF16294.5 KOS17896.1 - 3.2 8.1 13.9 0.49 10.7 7.5 2.6 3 0 0 3 3 3 0 RNSP1-SAP18 binding (RSB) motif ABC_tran PF00005.27 KOS17897.1 - 4.6e-46 156.7 0.0 2e-21 76.9 0.0 3.3 2 1 1 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 KOS17897.1 - 3.2e-20 72.0 2.7 3.2e-20 72.0 2.7 2.6 4 0 0 4 4 1 1 ABC transporter AAA_21 PF13304.6 KOS17897.1 - 4.5e-20 72.7 0.1 3e-05 24.0 0.0 4.2 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOS17897.1 - 7.9e-11 41.8 0.1 0.0047 16.4 0.1 4.3 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS17897.1 - 1e-08 34.8 0.0 0.0029 17.3 0.1 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS17897.1 - 1.9e-08 35.1 1.3 0.019 15.5 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KOS17897.1 - 5.1e-07 30.2 0.1 0.0031 17.9 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain AAA_15 PF13175.6 KOS17897.1 - 1.9e-06 27.8 0.1 0.047 13.4 0.0 2.7 3 0 0 3 3 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 KOS17897.1 - 4.5e-06 26.7 0.0 0.014 15.4 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOS17897.1 - 6.7e-06 26.2 0.0 0.029 14.5 0.0 3.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_22 PF13401.6 KOS17897.1 - 7.1e-06 26.3 0.0 0.15 12.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOS17897.1 - 1.1e-05 26.0 0.0 0.17 12.4 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOS17897.1 - 4.7e-05 23.8 0.0 0.36 11.3 0.0 3.2 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOS17897.1 - 4.9e-05 23.3 0.3 0.19 11.6 0.0 3.0 3 0 0 3 3 3 2 NACHT domain AAA_28 PF13521.6 KOS17897.1 - 6.9e-05 23.1 0.1 0.03 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOS17897.1 - 9.1e-05 22.5 0.2 0.39 10.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOS17897.1 - 0.00033 20.8 0.3 0.22 11.6 0.1 3.1 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 KOS17897.1 - 0.0007 20.0 0.7 1.7 9.1 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_27 PF13514.6 KOS17897.1 - 0.00082 19.0 0.0 0.18 11.4 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 KOS17897.1 - 0.00082 19.4 0.0 2.2 8.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 KOS17897.1 - 0.0009 19.0 0.5 2 8.1 0.0 3.7 4 0 0 4 4 4 1 AAA domain DUF2813 PF11398.8 KOS17897.1 - 0.0029 16.9 0.4 2 7.6 0.0 3.0 3 0 0 3 3 3 1 Protein of unknown function (DUF2813) NB-ARC PF00931.22 KOS17897.1 - 0.0048 16.1 0.7 6.6 5.8 0.0 3.3 3 1 0 3 3 3 0 NB-ARC domain AAA_17 PF13207.6 KOS17897.1 - 0.0049 17.3 0.4 1.3 9.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_25 PF13481.6 KOS17897.1 - 0.0066 16.0 0.1 0.73 9.4 0.0 3.2 4 1 0 4 4 2 1 AAA domain Roc PF08477.13 KOS17897.1 - 0.0073 16.5 0.0 4.2 7.6 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 KOS17897.1 - 0.0079 16.3 0.6 6 6.9 0.0 3.7 4 1 1 5 5 4 0 Dynamin family MCM PF00493.23 KOS17897.1 - 0.013 14.6 0.0 1.8 7.6 0.0 2.3 2 0 0 2 2 2 0 MCM P-loop domain NTPase_1 PF03266.15 KOS17897.1 - 0.017 15.1 0.3 1.2 9.0 0.2 2.5 2 0 0 2 2 2 0 NTPase FeoB_N PF02421.18 KOS17897.1 - 0.027 14.0 0.1 8.4 5.9 0.0 2.8 3 0 0 3 3 3 0 Ferrous iron transport protein B DUF815 PF05673.13 KOS17897.1 - 0.031 13.4 0.1 1.7 7.8 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 KOS17897.1 - 0.034 14.1 0.0 3.8 7.4 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_7 PF12775.7 KOS17897.1 - 0.046 13.2 0.0 2.3 7.7 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DAP3 PF10236.9 KOS17897.1 - 0.047 12.9 0.1 3.8 6.6 0.0 2.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 ABC_ATPase PF09818.9 KOS17897.1 - 0.074 11.8 1.3 19 3.9 0.0 3.6 4 0 0 4 4 4 0 Predicted ATPase of the ABC class MeaB PF03308.16 KOS17897.1 - 0.086 11.8 0.1 5.9 5.8 0.0 2.5 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KOS17897.1 - 0.1 12.3 2.1 4.1 7.1 0.1 3.1 3 1 0 3 3 2 0 AAA domain TsaE PF02367.17 KOS17897.1 - 0.15 12.1 0.4 30 4.6 0.0 3.1 2 1 1 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF87 PF01935.17 KOS17897.1 - 0.71 9.9 3.8 22 5.1 0.0 3.0 4 0 0 4 4 2 0 Helicase HerA, central domain IBR PF01485.21 KOS17898.1 - 1e-05 25.6 4.7 1e-05 25.6 4.7 4.4 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain RNA_polI_A34 PF08208.11 KOS17899.1 - 1.2e-44 152.9 4.6 1.2e-44 152.9 4.6 5.8 3 2 1 4 4 4 1 DNA-directed RNA polymerase I subunit RPA34.5 PAP2_3 PF14378.6 KOS17900.1 - 1.8e-21 76.7 16.6 1.8e-21 76.7 16.6 2.1 1 1 1 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 KOS17900.1 - 9.8e-11 41.6 5.8 9.8e-11 41.6 5.8 2.7 2 1 2 4 4 4 1 PAP2 superfamily SHMT PF00464.19 KOS17901.1 - 3.2e-207 687.9 0.0 3.8e-207 687.6 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Aminotran_5 PF00266.19 KOS17901.1 - 0.00029 19.9 0.0 0.00045 19.3 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOS17901.1 - 0.12 11.6 0.0 0.29 10.4 0.0 1.7 1 1 0 1 1 1 0 Beta-eliminating lyase Bromodomain PF00439.25 KOS17902.1 - 2.9e-19 68.9 0.5 7.2e-19 67.6 0.5 1.7 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 KOS17902.1 - 7e-10 38.8 0.0 1.4e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 Bromodomain associated PBP1_TM PF14812.6 KOS17902.1 - 4.6 7.7 19.3 0.84 10.0 6.9 3.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal VanZ PF04892.12 KOS17903.1 - 1.8e-07 31.8 1.6 2.5e-07 31.4 1.6 1.2 1 0 0 1 1 1 1 VanZ like family TetR_C_23 PF17931.1 KOS17903.1 - 0.048 13.8 0.0 0.079 13.1 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RseC_MucC PF04246.12 KOS17903.1 - 0.38 10.7 1.1 23 4.9 0.7 2.1 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF4131 PF13567.6 KOS17903.1 - 2.4 7.8 6.1 24 4.5 4.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) Prefoldin PF02996.17 KOS17904.1 - 6.6e-33 113.2 0.1 1.2e-32 112.3 0.1 1.4 1 0 0 1 1 1 1 Prefoldin subunit APG17 PF04108.12 KOS17904.1 - 0.013 14.7 1.5 0.018 14.2 0.0 1.7 2 0 0 2 2 2 0 Autophagy protein Apg17 FlaC_arch PF05377.11 KOS17904.1 - 0.034 14.6 0.3 3.2 8.2 0.1 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Filament PF00038.21 KOS17904.1 - 0.036 13.6 5.5 2 7.9 0.1 2.0 2 0 0 2 2 2 0 Intermediate filament protein Prefoldin_2 PF01920.20 KOS17904.1 - 0.054 13.4 6.6 0.22 11.5 0.1 3.2 3 1 0 3 3 3 0 Prefoldin subunit HSBP1 PF06825.12 KOS17904.1 - 0.097 12.5 0.6 0.19 11.6 0.6 1.4 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Pkinase PF00069.25 KOS17905.1 - 8.1e-72 241.7 0.0 1e-71 241.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17905.1 - 3.2e-29 102.0 0.0 4.3e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17905.1 - 5.3e-07 29.2 0.0 8.3e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOS17905.1 - 5.1e-05 22.2 0.0 0.00011 21.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOS17905.1 - 0.00014 21.2 0.0 0.00024 20.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS17905.1 - 0.00035 20.6 0.0 0.00055 19.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RF-1 PF00472.20 KOS17906.1 - 1.4e-14 54.0 4.7 2.2e-14 53.4 4.7 1.2 1 0 0 1 1 1 1 RF-1 domain RRM_1 PF00076.22 KOS17907.1 - 3.4e-09 36.4 0.0 6.4e-09 35.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS17907.1 - 0.00029 20.4 0.0 0.0007 19.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS17907.1 - 0.068 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif DBINO PF13892.6 KOS17907.1 - 0.27 11.6 4.1 0.48 10.8 4.1 1.3 1 0 0 1 1 1 0 DNA-binding domain Ferric_reduct PF01794.19 KOS17908.1 - 6.4e-20 71.5 13.6 1.6e-19 70.2 13.6 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOS17908.1 - 4.8e-11 43.0 0.0 3e-06 27.4 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS17908.1 - 0.00027 21.0 0.0 0.0096 16.0 0.0 2.9 2 1 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 KOS17908.1 - 0.015 15.9 0.0 4.7 7.9 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Ras PF00071.22 KOS17909.1 - 1.1e-41 142.1 0.0 4.8e-41 140.1 0.0 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOS17909.1 - 2.3e-30 105.3 0.0 3.6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS17909.1 - 5.5e-11 42.2 0.0 5e-10 39.1 0.0 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS17909.1 - 3.6e-05 23.8 0.0 6.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS17909.1 - 0.00013 21.4 0.0 0.00019 20.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOS17909.1 - 0.00074 19.1 0.0 0.0043 16.6 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain CENP-B_dimeris PF09026.10 KOS17909.1 - 0.0062 16.9 6.0 0.012 16.0 6.0 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain PduV-EutP PF10662.9 KOS17909.1 - 0.0069 16.1 0.0 0.48 10.2 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 KOS17909.1 - 0.0073 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 KOS17909.1 - 0.016 15.1 0.0 0.19 11.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 KOS17909.1 - 0.018 15.2 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOS17909.1 - 0.018 15.5 0.2 0.098 13.2 0.0 2.0 2 0 0 2 2 2 0 ABC transporter NACHT PF05729.12 KOS17909.1 - 0.065 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 KOS17909.1 - 0.069 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOS17909.1 - 0.11 12.8 0.0 0.18 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOS17909.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS17909.1 - 0.14 12.5 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NOA36 PF06524.12 KOS17909.1 - 0.46 9.8 7.2 0.62 9.3 7.2 1.1 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 KOS17909.1 - 1.6 8.4 7.7 2.3 7.9 7.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF229 PF02995.17 KOS17910.1 - 0.11 11.0 0.0 0.15 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) BCNT PF07572.12 KOS17911.1 - 6.5e-24 83.8 1.6 1.3e-23 82.8 1.6 1.5 1 0 0 1 1 1 1 Bucentaur or craniofacial development CDC45 PF02724.14 KOS17911.1 - 1.3 7.2 11.6 2.3 6.4 11.6 1.4 1 0 0 1 1 1 0 CDC45-like protein His_biosynth PF00977.21 KOS17912.1 - 9.8e-35 120.1 0.0 1.3e-34 119.6 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein Anillin PF08174.11 KOS17913.1 - 7.6e-11 42.6 0.0 2.6e-10 40.9 0.0 1.9 1 0 0 1 1 1 1 Cell division protein anillin PH PF00169.29 KOS17913.1 - 5.2e-09 36.6 0.0 1.7e-08 34.9 0.0 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KOS17913.1 - 0.007 16.8 0.0 0.018 15.5 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain DUF1899 PF08953.11 KOS17914.1 - 9.1e-36 121.6 0.1 1.9e-35 120.6 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 KOS17914.1 - 1.6e-20 72.7 0.6 2.9e-20 71.9 0.6 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 KOS17914.1 - 3.1e-16 59.5 2.3 2.6e-05 24.9 0.3 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS17914.1 - 1.3e-07 31.9 0.0 0.0006 20.1 0.1 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SlyX PF04102.12 KOS17914.1 - 0.013 16.1 1.4 0.013 16.1 1.4 2.4 2 0 0 2 2 2 0 SlyX AlphaC_C PF17480.2 KOS17914.1 - 0.017 15.1 0.8 0.055 13.5 0.6 1.9 2 0 0 2 2 2 0 AlphaC C-terminal DUF16 PF01519.16 KOS17914.1 - 0.028 14.9 0.8 0.06 13.8 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 Nup160 PF11715.8 KOS17914.1 - 0.033 12.8 0.1 0.57 8.8 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 STE PF02200.16 KOS17915.1 - 1e-56 190.0 0.1 1.9e-56 189.2 0.1 1.4 1 0 0 1 1 1 1 STE like transcription factor Vma12 PF11712.8 KOS17916.1 - 1.8e-25 89.6 0.1 2.4e-25 89.2 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1772 PF08592.11 KOS17916.1 - 0.0032 17.8 0.5 0.0039 17.5 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) DUF4212 PF13937.6 KOS17916.1 - 0.034 14.5 0.7 0.053 13.9 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) DUF4602 PF15375.6 KOS17917.1 - 4.4e-09 36.8 6.8 5.9e-08 33.1 6.8 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) NOA36 PF06524.12 KOS17918.1 - 0.0093 15.3 17.1 0.011 15.1 17.1 1.0 1 0 0 1 1 1 1 NOA36 protein PBP1_TM PF14812.6 KOS17918.1 - 0.034 14.5 15.7 0.044 14.1 15.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TLP-20 PF06088.11 KOS17918.1 - 0.19 11.6 7.5 0.2 11.5 7.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) FAM176 PF14851.6 KOS17918.1 - 0.23 11.1 9.4 0.26 11.0 9.4 1.2 1 0 0 1 1 1 0 FAM176 family WRNPLPNID PF15017.6 KOS17918.1 - 0.23 12.3 12.1 0.63 11.0 12.1 1.7 1 1 0 1 1 1 0 Putative WW-binding domain and destruction box DUF2457 PF10446.9 KOS17918.1 - 0.53 9.4 18.4 0.58 9.2 18.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PGA2 PF07543.12 KOS17918.1 - 0.56 10.2 7.9 0.62 10.0 7.9 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 DNA_pol_phi PF04931.13 KOS17918.1 - 0.63 8.1 16.3 0.66 8.0 16.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 KOS17918.1 - 0.65 10.0 10.5 0.76 9.8 10.5 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 KOS17918.1 - 1 7.3 9.9 1 7.3 9.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 KOS17918.1 - 2.6 6.2 15.4 2.7 6.2 15.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 KOS17918.1 - 3.7 5.7 14.1 3.5 5.7 14.1 1.0 1 0 0 1 1 1 0 Nop14-like family GCIP PF13324.6 KOS17918.1 - 5.5 6.5 9.5 5.4 6.6 9.5 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PPP4R2 PF09184.11 KOS17918.1 - 7.6 6.0 14.9 8.2 5.9 14.9 1.1 1 0 0 1 1 1 0 PPP4R2 CLP_protease PF00574.23 KOS17919.1 - 4e-66 222.4 0.2 5.3e-66 222.0 0.2 1.1 1 0 0 1 1 1 1 Clp protease ketoacyl-synt PF00109.26 KOS17920.1 - 1.8e-56 191.6 5.4 1.8e-56 191.6 5.4 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOS17920.1 - 1.7e-34 118.3 0.4 3.1e-34 117.5 0.4 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 KOS17920.1 - 0.00011 21.6 0.8 0.00043 19.7 0.5 2.0 3 0 0 3 3 3 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS17920.1 - 0.027 14.1 2.7 0.059 13.0 0.0 2.8 3 2 1 4 4 4 0 Thiolase, C-terminal domain KAsynt_C_assoc PF16197.5 KOS17920.1 - 0.17 12.3 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 Ketoacyl-synthetase C-terminal extension ANAPC1 PF12859.7 KOS17921.1 - 3.9e-37 127.7 3.4 4.8e-37 127.4 0.2 2.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 KOS17921.1 - 0.054 14.0 1.5 21 5.8 0.0 4.3 4 0 0 4 4 4 0 Proteasome/cyclosome repeat Ubiq_cyt_C_chap PF03981.12 KOS17922.1 - 6.2e-35 120.3 0.6 1.5e-34 119.1 0.0 1.9 3 0 0 3 3 3 1 Ubiquinol-cytochrome C chaperone DUF4040 PF13244.6 KOS17922.1 - 0.024 14.8 0.5 0.057 13.6 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4040) DHFR_1 PF00186.19 KOS17923.1 - 3.2e-30 105.0 0.0 4.7e-30 104.4 0.0 1.3 1 0 0 1 1 1 1 Dihydrofolate reductase zf-HC5HC2H_2 PF13832.6 KOS17924.1 - 1.3e-33 115.4 6.9 1.3e-33 115.4 6.9 2.4 2 0 0 2 2 2 1 PHD-zinc-finger like domain EPL1 PF10513.9 KOS17924.1 - 3.6e-30 105.4 1.9 1.8e-29 103.1 0.5 2.7 2 1 0 2 2 2 1 Enhancer of polycomb-like zf-HC5HC2H PF13771.6 KOS17924.1 - 3e-26 91.5 5.8 3e-26 91.5 5.8 3.2 3 0 0 3 3 3 1 PHD-like zinc-binding domain PHD_2 PF13831.6 KOS17924.1 - 1.2e-14 53.5 2.2 1.2e-14 53.5 2.2 2.1 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 KOS17924.1 - 2.4e-08 33.7 26.8 8.3e-08 32.0 12.8 2.7 2 0 0 2 2 2 2 PHD-finger zf-PHD-like PF15446.6 KOS17924.1 - 0.0088 15.7 2.0 0.0088 15.7 2.0 2.3 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain COesterase PF00135.28 KOS17925.1 - 5.2e-82 276.4 0.0 7.4e-82 275.9 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOS17925.1 - 8.7e-07 29.0 0.1 2.7e-05 24.1 0.1 2.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOS17925.1 - 0.031 13.8 0.0 0.051 13.0 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DUF441 PF04284.13 KOS17926.1 - 0.097 12.7 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF441) Histone PF00125.24 KOS17927.1 - 5.3e-22 78.6 1.6 6.9e-22 78.2 1.6 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOS17927.1 - 4.9e-05 23.5 0.0 0.00011 22.4 0.0 1.6 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 KOS17927.1 - 0.00026 21.4 0.0 0.00046 20.6 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A DUF1018 PF06252.12 KOS17927.1 - 0.043 14.8 0.4 0.076 14.0 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1018) RP-C PF03428.13 KOS17927.1 - 0.05 13.2 0.1 0.12 12.0 0.1 1.5 1 1 0 1 1 1 0 Replication protein C N-terminal domain Myosin_head PF00063.21 KOS17928.1 - 6.6e-216 718.6 3.7 8e-216 718.4 3.7 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) AAA_22 PF13401.6 KOS17928.1 - 5e-05 23.6 0.1 0.00024 21.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS17928.1 - 0.0022 18.4 0.0 0.0051 17.2 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 KOS17928.1 - 0.052 13.3 0.0 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.20 KOS17928.1 - 0.052 12.6 0.0 0.084 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 KOS17928.1 - 0.052 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 KOS17928.1 - 0.053 13.0 0.5 4.8 6.6 0.0 3.1 4 0 0 4 4 4 0 PhoH-like protein NACHT PF05729.12 KOS17928.1 - 0.066 13.1 0.0 0.35 10.8 0.0 2.1 2 0 0 2 2 2 0 NACHT domain HSF_DNA-bind PF00447.17 KOS17928.1 - 0.12 13.1 0.2 0.12 13.1 0.2 2.0 2 0 0 2 2 2 0 HSF-type DNA-binding NAP PF00956.18 KOS17929.1 - 3.6e-97 324.8 1.0 3.6e-97 324.8 1.0 1.5 2 0 0 2 2 2 1 Nucleosome assembly protein (NAP) Glyco_hydro_5_C PF18564.1 KOS17930.1 - 6.8e-18 65.0 0.1 1.8e-17 63.6 0.0 1.8 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 KOS17930.1 - 1.5e-10 41.0 1.3 1.6e-07 31.0 0.5 2.6 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Pkinase PF00069.25 KOS17931.1 - 1.2e-61 208.4 0.0 1.7e-61 207.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17931.1 - 2.4e-47 161.4 0.0 3.7e-47 160.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17931.1 - 9e-08 31.8 0.0 4.7e-06 26.1 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOS17931.1 - 0.0033 16.8 0.0 0.0058 16.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOS17931.1 - 0.0073 15.1 0.0 0.016 14.0 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS17931.1 - 0.065 13.1 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family SAM_3 PF18016.1 KOS17931.1 - 0.074 12.9 0.3 0.17 11.7 0.3 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Vps51 PF08700.11 KOS17932.1 - 1.9e-27 95.2 0.1 3.3e-27 94.4 0.1 1.4 1 0 0 1 1 1 1 Vps51/Vps67 Dor1 PF04124.12 KOS17932.1 - 0.00019 20.3 0.1 0.00024 19.9 0.1 1.1 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 KOS17932.1 - 0.09 13.0 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 NIF3 PF01784.18 KOS17933.1 - 1.9e-57 194.7 0.0 2.3e-57 194.5 0.0 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ThuA PF06283.11 KOS17933.1 - 0.043 14.0 0.0 0.059 13.6 0.0 1.3 1 1 0 1 1 1 0 Trehalose utilisation TPR_16 PF13432.6 KOS17934.1 - 2e-22 79.6 81.4 3.1e-06 27.7 1.6 14.5 12 3 3 15 15 15 7 Tetratricopeptide repeat TPR_2 PF07719.17 KOS17934.1 - 8e-22 75.6 63.3 0.026 14.6 0.0 17.3 17 0 0 17 17 17 9 Tetratricopeptide repeat TPR_14 PF13428.6 KOS17934.1 - 3.1e-21 74.3 69.0 0.0011 19.6 0.1 17.0 13 4 5 18 18 16 9 Tetratricopeptide repeat TPR_19 PF14559.6 KOS17934.1 - 4.8e-19 68.6 50.0 0.0039 17.7 0.4 12.5 12 1 1 13 13 12 6 Tetratricopeptide repeat TPR_17 PF13431.6 KOS17934.1 - 1.1e-15 56.7 16.4 0.095 13.1 0.0 13.0 15 0 0 15 15 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOS17934.1 - 5.1e-15 54.6 50.2 0.01 15.6 0.0 14.4 17 0 0 17 17 16 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOS17934.1 - 8.4e-15 53.7 34.6 0.038 14.2 0.0 13.5 15 0 0 15 15 14 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOS17934.1 - 4.6e-13 49.3 54.2 0.0039 17.4 1.0 13.4 12 2 1 13 13 12 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOS17934.1 - 3.1e-12 45.6 33.4 0.014 15.4 0.0 13.1 13 1 1 14 14 13 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS17934.1 - 5.4e-11 42.0 30.7 0.037 13.7 0.4 11.0 12 1 0 12 12 12 4 TPR repeat TPR_6 PF13174.6 KOS17934.1 - 6.5e-08 32.7 37.9 2.9 8.7 0.1 14.3 15 0 0 15 15 13 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS17934.1 - 1.3e-05 25.2 27.1 0.0049 17.0 0.2 7.9 8 1 0 8 8 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS17934.1 - 2.1e-05 24.6 14.7 0.78 10.0 0.1 7.2 4 2 4 9 9 9 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_22 PF18833.1 KOS17934.1 - 0.00026 21.0 0.0 0.00069 19.7 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat Ribosomal_60s PF00428.19 KOS17934.1 - 0.035 14.7 2.1 0.24 12.0 0.5 3.1 2 0 0 2 2 2 0 60s Acidic ribosomal protein DUF4919 PF16266.5 KOS17934.1 - 0.05 13.6 0.0 0.2 11.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4919) ChAPs PF09295.10 KOS17934.1 - 0.11 11.4 0.2 25 3.7 0.1 3.4 4 0 0 4 4 4 0 ChAPs (Chs5p-Arf1p-binding proteins) Gcn1_N PF12074.8 KOS17934.1 - 0.15 11.4 0.1 0.32 10.2 0.1 1.5 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Coatomer_WDAD PF04053.14 KOS17934.1 - 0.2 10.7 0.0 0.73 8.8 0.0 1.8 1 1 0 1 1 1 0 Coatomer WD associated region Sel1 PF08238.12 KOS17934.1 - 0.47 11.2 5.4 1 10.2 0.1 4.4 5 0 0 5 5 4 0 Sel1 repeat HemY_N PF07219.13 KOS17934.1 - 1.5 9.0 20.2 9.1 6.5 0.1 6.6 6 1 1 7 7 7 0 HemY protein N-terminus Fis1_TPR_C PF14853.6 KOS17934.1 - 1.9 8.6 8.7 9.5 6.4 0.1 6.1 7 1 1 8 8 6 0 Fis1 C-terminal tetratricopeptide repeat RMI1_N PF08585.12 KOS17935.1 - 1.4e-52 178.6 0.0 1.7e-52 178.4 0.0 1.0 1 0 0 1 1 1 1 RecQ mediated genome instability protein DNA_ligase_A_M PF01068.21 KOS17936.1 - 1.5e-49 168.4 0.1 6.7e-47 159.8 0.0 2.2 2 0 0 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOS17936.1 - 2.6e-25 89.7 0.0 5e-25 88.8 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KOS17936.1 - 7.3e-19 68.2 0.0 3.1e-18 66.2 0.0 2.1 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 KOS17936.1 - 0.00017 21.9 0.0 0.00031 21.1 0.0 1.4 1 0 0 1 1 1 1 RNA ligase mRNA_cap_enzyme PF01331.19 KOS17936.1 - 0.018 14.9 0.1 1.1 9.1 0.0 2.4 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain KNOX1 PF03790.13 KOS17936.1 - 0.12 12.1 0.1 0.75 9.6 0.0 2.2 2 0 0 2 2 2 0 KNOX1 domain DUF5572 PF17733.1 KOS17936.1 - 1.5 8.7 4.6 1.6 8.7 0.3 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5572) CSN8_PSD8_EIF3K PF10075.9 KOS17937.1 - 1.3e-34 119.3 0.0 1.7e-34 118.9 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family BolA PF01722.18 KOS17938.1 - 1.3e-20 73.4 0.0 3.4e-20 72.1 0.0 1.6 1 1 0 1 1 1 1 BolA-like protein Adaptin_N PF01602.20 KOS17939.1 - 9.7e-136 453.4 6.3 1.3e-135 452.9 6.3 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOS17939.1 - 1.8e-63 213.4 3.3 1.5e-60 203.9 0.4 2.7 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS17939.1 - 1e-17 64.3 0.2 3.2e-08 33.8 0.0 5.2 2 2 5 7 7 7 4 HEAT repeats HEAT PF02985.22 KOS17939.1 - 6.4e-11 41.5 5.5 0.013 15.6 0.0 6.4 8 0 0 8 8 5 2 HEAT repeat HEAT_EZ PF13513.6 KOS17939.1 - 0.00022 21.6 0.4 0.63 10.6 0.0 4.9 4 1 1 5 5 5 1 HEAT-like repeat CLASP_N PF12348.8 KOS17939.1 - 0.016 14.8 0.3 1.6 8.2 0.0 3.1 2 1 1 3 3 3 0 CLASP N terminal DUF3818 PF12825.7 KOS17939.1 - 0.019 14.0 0.4 0.11 11.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function in PX-proteins (DUF3818) RTP1_C1 PF10363.9 KOS17939.1 - 0.043 14.0 0.7 2.2 8.5 0.0 3.8 2 2 2 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 UNC45-central PF11701.8 KOS17939.1 - 0.11 12.5 3.6 1.3 9.0 0.1 3.1 4 0 0 4 4 4 0 Myosin-binding striated muscle assembly central Atx10homo_assoc PF09759.9 KOS17939.1 - 0.11 12.5 0.0 8.7 6.4 0.0 3.1 3 0 0 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 KOS17939.1 - 0.12 12.4 1.1 8.3 6.6 0.0 4.3 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat CAAP1 PF15335.6 KOS17939.1 - 0.16 12.5 0.4 0.86 10.2 0.1 2.5 2 0 0 2 2 1 0 Caspase activity and apoptosis inhibitor 1 DUF445 PF04286.12 KOS17939.1 - 0.23 11.2 4.5 2.3 7.9 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF445) SNF2_N PF00176.23 KOS17940.1 - 1.7e-65 221.1 0.7 6e-65 219.2 0.8 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 KOS17940.1 - 5.3e-48 162.8 15.7 5.3e-48 162.8 15.7 5.7 4 2 2 6 6 6 1 DNA-binding domain Helicase_C PF00271.31 KOS17940.1 - 1.8e-20 73.3 0.0 5e-20 71.9 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17940.1 - 1.7e-06 28.2 0.0 1.7e-06 28.2 0.0 3.8 3 2 1 4 4 4 1 Type III restriction enzyme, res subunit ASFV_J13L PF05568.11 KOS17940.1 - 0.023 14.5 0.1 0.061 13.1 0.1 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein Kinesin PF00225.23 KOS17941.1 - 1.9e-107 359.0 3.3 4.6e-107 357.8 3.3 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOS17941.1 - 4.4e-56 189.0 0.1 1.2e-55 187.6 0.1 1.8 1 0 0 1 1 1 1 Microtubule binding WEMBL PF05701.11 KOS17941.1 - 8.6e-05 21.4 42.3 0.00016 20.6 20.4 3.2 2 1 1 3 3 3 2 Weak chloroplast movement under blue light TMF_DNA_bd PF12329.8 KOS17941.1 - 0.0013 18.7 1.8 0.0013 18.7 1.8 4.6 3 2 0 3 3 3 2 TATA element modulatory factor 1 DNA binding AAA_16 PF13191.6 KOS17941.1 - 0.03 14.7 0.0 0.03 14.7 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain HALZ PF02183.18 KOS17941.1 - 0.24 11.7 0.1 0.24 11.7 0.1 3.3 3 0 0 3 3 3 0 Homeobox associated leucine zipper Bacillus_HBL PF05791.11 KOS17941.1 - 0.32 10.8 6.8 0.069 13.0 0.5 2.6 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DivIC PF04977.15 KOS17941.1 - 0.39 10.5 0.1 0.39 10.5 0.1 4.4 2 1 1 4 4 4 0 Septum formation initiator bZIP_1 PF00170.21 KOS17941.1 - 3.7 7.7 18.4 0.46 10.6 1.8 4.7 3 1 1 4 4 4 0 bZIP transcription factor XhlA PF10779.9 KOS17941.1 - 8.3 6.7 9.3 13 6.1 2.1 4.1 3 0 0 3 3 3 0 Haemolysin XhlA TP_methylase PF00590.20 KOS17942.1 - 1.7e-23 83.7 0.0 2.7e-23 83.0 0.0 1.3 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases SpoVAD PF07451.11 KOS17942.1 - 0.18 10.4 0.0 0.29 9.8 0.0 1.3 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) zf-C2H2_jaz PF12171.8 KOS17943.1 - 1.1e-08 35.1 0.1 2e-08 34.3 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS17943.1 - 0.00017 21.9 0.5 0.0003 21.1 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type SNRNP27 PF08648.12 KOS17943.1 - 0.0026 17.8 0.3 0.0089 16.1 0.3 2.0 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins zf-DBF PF07535.12 KOS17943.1 - 0.0082 16.2 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 DBF zinc finger zf-C2H2 PF00096.26 KOS17943.1 - 0.23 12.0 0.2 0.4 11.2 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type FemAB PF02388.16 KOS17943.1 - 7.3 5.3 11.4 1 8.2 5.8 1.9 2 0 0 2 2 2 0 FemAB family Cullin PF00888.22 KOS17945.1 - 1.1e-193 645.3 13.7 1.5e-193 644.9 13.7 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOS17945.1 - 1.2e-25 89.3 4.1 1.2e-25 89.3 4.1 3.5 4 0 0 4 4 4 1 Cullin protein neddylation domain WAC_Acf1_DNA_bd PF10537.9 KOS17945.1 - 0.004 17.6 2.3 0.022 15.3 0.2 3.4 4 0 0 4 4 4 1 ATP-utilising chromatin assembly and remodelling N-terminal TrmE_N PF10396.9 KOS17945.1 - 0.095 13.0 0.1 0.95 9.8 0.0 2.7 3 0 0 3 3 3 0 GTP-binding protein TrmE N-terminus PRD PF00874.20 KOS17945.1 - 9.5 6.6 10.2 12 6.3 0.5 3.7 3 0 0 3 3 3 0 PRD domain Avl9 PF09794.9 KOS17946.1 - 1.2e-141 471.8 0.0 1.9e-141 471.2 0.0 1.3 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 KOS17946.1 - 4.8e-05 23.1 6.7 0.0022 17.6 0.2 3.8 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2347) ANAPC_CDC26 PF10471.9 KOS17946.1 - 0.0036 18.1 12.7 0.0036 18.1 12.7 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex APC subunit CDC26 SUIM_assoc PF16619.5 KOS17946.1 - 0.13 12.4 10.5 0.43 10.7 10.5 1.9 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 GREB1 PF15782.5 KOS17946.1 - 0.32 8.1 2.2 0.42 7.7 2.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Spt20 PF12090.8 KOS17946.1 - 0.45 10.1 13.5 0.8 9.3 13.5 1.3 1 0 0 1 1 1 0 Spt20 family Ndc1_Nup PF09531.10 KOS17946.1 - 0.7 8.5 5.4 1.1 7.9 5.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 KOS17946.1 - 2.6 6.7 3.8 3.7 6.2 3.8 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 KOS17946.1 - 3.8 8.5 6.6 9.4 7.3 6.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Acyltransferase PF01553.21 KOS17947.1 - 0.0049 16.5 0.0 0.0083 15.8 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Phosphorylase PF00343.20 KOS17948.1 - 0 1053.1 0.0 0 1052.9 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Coatomer_b_Cpla PF14806.6 KOS17948.1 - 0.14 12.2 0.0 0.54 10.2 0.0 2.0 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform Pkinase PF00069.25 KOS17949.1 - 4.3e-61 206.6 0.0 3.7e-60 203.5 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17949.1 - 4.9e-27 94.8 0.0 3.2e-25 88.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS17949.1 - 9.2e-05 21.5 0.0 0.00017 20.7 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS17949.1 - 0.00017 21.0 0.1 0.011 15.1 0.0 2.1 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS17949.1 - 0.00073 19.5 0.0 0.0023 17.9 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOS17949.1 - 0.0018 17.6 0.0 0.18 11.1 0.0 2.3 1 1 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KOS17949.1 - 0.024 14.3 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 KOS17949.1 - 0.064 12.9 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 RIO1 family CorA PF01544.18 KOS17950.1 - 0.009 15.4 6.8 0.018 14.3 6.8 1.5 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Pyrid_ox_like PF16242.5 KOS17951.1 - 2.6e-24 85.5 0.0 3.6e-24 85.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Putative_PNPOx PF01243.20 KOS17951.1 - 3e-10 40.1 0.0 5.4e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 KOS17951.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative FMN-binding domain SIL1 PF16782.5 KOS17951.1 - 0.14 11.4 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 ATP-synt_F PF01990.17 KOS17952.1 - 1.1e-33 115.4 0.1 1.3e-33 115.2 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit E1_DerP2_DerF2 PF02221.15 KOS17953.1 - 1.1e-28 100.4 0.3 1.3e-28 100.1 0.3 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 KOS17953.1 - 0.00092 19.6 0.0 0.0015 18.9 0.0 1.4 1 1 0 1 1 1 1 ML-like domain Pertus-S4-tox PF09275.10 KOS17953.1 - 0.098 13.0 0.7 1.2 9.4 0.2 2.1 2 0 0 2 2 2 0 Pertussis toxin S4 subunit PHD PF00628.29 KOS17954.1 - 8.3e-07 28.8 8.9 8.3e-07 28.8 8.9 1.7 2 0 0 2 2 2 1 PHD-finger SET PF00856.28 KOS17954.1 - 1e-05 26.0 0.0 2.7e-05 24.6 0.0 1.8 1 1 0 1 1 1 1 SET domain Glycos_transf_4 PF00953.21 KOS17955.1 - 1.4e-29 103.2 9.4 1.4e-29 103.2 9.4 1.9 3 0 0 3 3 3 1 Glycosyl transferase family 4 Methyltransf_16 PF10294.9 KOS17956.1 - 3e-10 40.1 0.0 0.00045 20.0 0.0 2.1 2 0 0 2 2 2 2 Lysine methyltransferase DUF3446 PF11928.8 KOS17956.1 - 0.027 14.8 9.1 0.027 14.8 9.1 1.7 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF515 PF04415.12 KOS17956.1 - 1.2 7.5 3.1 1.6 7.1 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Aconitase PF00330.20 KOS17957.1 - 4.9e-161 536.8 0.0 6.9e-161 536.3 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOS17957.1 - 6.3e-41 139.8 0.0 1.1e-40 139.0 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain TPR_10 PF13374.6 KOS17958.1 - 0.00021 21.1 0.6 0.068 13.1 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF2418 PF10332.9 KOS17959.1 - 2.4e-35 120.9 0.2 6.8e-35 119.5 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2418) DUF2737 PF10930.8 KOS17959.1 - 0.068 12.7 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2737) ILVD_EDD PF00920.21 KOS17960.1 - 4.4e-212 705.3 0.1 5e-212 705.1 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family ABC_tran PF00005.27 KOS17961.1 - 8.1e-53 178.6 0.1 4.3e-30 105.0 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOS17961.1 - 4.4e-38 131.5 25.6 1.1e-19 71.2 12.5 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 KOS17961.1 - 1.7e-10 40.7 2.0 0.012 15.1 0.0 4.3 3 1 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS17961.1 - 1e-08 34.8 1.5 0.00056 19.6 0.2 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS17961.1 - 7.6e-08 33.1 0.7 3e-05 24.6 0.1 2.4 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 KOS17961.1 - 2.7e-07 30.7 0.1 0.0069 16.2 0.0 4.1 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOS17961.1 - 1.1e-06 28.7 0.0 0.0019 18.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 KOS17961.1 - 1.1e-06 28.4 0.0 0.041 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOS17961.1 - 8.2e-06 26.1 0.1 0.17 12.1 0.0 2.9 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 KOS17961.1 - 3.4e-05 23.9 0.1 0.065 13.3 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 KOS17961.1 - 3.4e-05 24.3 0.1 0.39 11.1 0.0 2.9 2 0 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 KOS17961.1 - 0.0003 20.9 2.3 0.0056 16.8 0.1 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain NB-ARC PF00931.22 KOS17961.1 - 0.00031 20.0 0.8 1.9 7.6 0.0 3.8 3 1 0 3 3 3 2 NB-ARC domain T2SSE PF00437.20 KOS17961.1 - 0.00063 18.9 0.0 0.27 10.2 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein NACHT PF05729.12 KOS17961.1 - 0.0013 18.7 0.0 1.4 8.8 0.0 2.6 2 0 0 2 2 2 2 NACHT domain Dynamin_N PF00350.23 KOS17961.1 - 0.0013 18.8 1.4 1.3 9.0 0.1 2.5 2 0 0 2 2 2 2 Dynamin family cobW PF02492.19 KOS17961.1 - 0.0014 18.3 0.1 0.7 9.5 0.0 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain FtsK_SpoIIIE PF01580.18 KOS17961.1 - 0.004 16.5 0.4 0.46 9.8 0.0 2.5 2 0 0 2 2 2 1 FtsK/SpoIIIE family SbcCD_C PF13558.6 KOS17961.1 - 0.0096 16.1 0.0 4.5 7.6 0.0 2.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Viral_helicase1 PF01443.18 KOS17961.1 - 0.0099 15.6 0.0 5.8 6.6 0.0 2.6 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 KOS17961.1 - 0.012 15.6 0.4 3.7 7.4 0.1 2.4 2 0 0 2 2 2 0 NTPase AAA_30 PF13604.6 KOS17961.1 - 0.013 15.3 0.5 1.3 8.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain Pox_A32 PF04665.12 KOS17961.1 - 0.029 13.8 2.0 0.7 9.3 0.1 2.3 2 0 0 2 2 2 0 Poxvirus A32 protein AAA_33 PF13671.6 KOS17961.1 - 0.037 14.2 0.0 8.2 6.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.7 KOS17961.1 - 0.039 12.9 0.1 0.12 11.2 0.0 1.7 2 0 0 2 2 2 0 AAA-like domain AAA_7 PF12775.7 KOS17961.1 - 0.044 13.3 0.0 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region Septin PF00735.18 KOS17961.1 - 0.047 13.0 0.1 6.5 5.9 0.0 2.4 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 KOS17961.1 - 0.068 12.9 0.1 15 5.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOS17961.1 - 0.071 12.4 0.1 1.6 7.9 0.1 2.2 2 0 0 2 2 2 0 Zeta toxin DUF2075 PF09848.9 KOS17961.1 - 0.081 12.1 0.1 1 8.5 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) DAP3 PF10236.9 KOS17961.1 - 0.092 11.9 1.6 4.2 6.4 0.2 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Roc PF08477.13 KOS17961.1 - 0.11 12.8 0.1 26 5.1 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 KOS17961.1 - 0.14 11.8 0.1 2.9 7.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 KOS17961.1 - 0.17 11.6 0.5 5 6.8 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein ABC_ATPase PF09818.9 KOS17961.1 - 0.46 9.2 1.5 3.7 6.2 0.2 2.8 4 0 0 4 4 4 0 Predicted ATPase of the ABC class EF-hand_7 PF13499.6 KOS17962.1 - 7.9e-25 87.1 9.6 4e-16 59.2 1.5 3.0 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 KOS17962.1 - 2.9e-24 82.7 14.6 2.2e-08 33.1 0.2 4.8 5 0 0 5 5 5 3 EF hand EF-hand_6 PF13405.6 KOS17962.1 - 3.2e-24 82.7 5.6 3.8e-06 26.4 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 KOS17962.1 - 4.9e-17 60.6 15.5 3.5e-05 23.1 0.1 4.6 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 KOS17962.1 - 1.9e-13 50.0 13.6 8.1e-05 22.4 1.2 3.9 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 KOS17962.1 - 9.5e-09 35.1 9.3 0.004 17.1 0.2 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 KOS17962.1 - 2.1e-05 24.7 0.9 0.0085 16.4 0.1 3.0 2 1 1 3 3 3 2 EF-hand domain SPARC_Ca_bdg PF10591.9 KOS17962.1 - 0.00064 20.0 3.8 0.94 9.8 0.5 3.1 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1679 PF07914.11 KOS17962.1 - 0.017 14.0 0.5 2.9 6.6 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1679) EF-hand_14 PF17959.1 KOS17962.1 - 0.16 12.3 3.2 6.7 7.1 0.0 3.6 3 1 0 3 3 3 0 EF-hand domain EF-hand_10 PF14788.6 KOS17962.1 - 0.31 10.9 5.2 1.2 9.0 0.1 3.6 5 0 0 5 5 5 0 EF hand Caleosin PF05042.13 KOS17962.1 - 0.34 10.8 3.0 31 4.4 0.0 3.5 2 1 2 4 4 4 0 Caleosin related protein Acyl-CoA_dh_1 PF00441.24 KOS17963.1 - 2.8e-42 144.5 0.3 3.8e-42 144.0 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOS17963.1 - 1.1e-21 77.5 0.0 2.3e-21 76.6 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOS17963.1 - 4.4e-21 74.9 0.1 8.4e-21 74.0 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Cyt-b5 PF00173.28 KOS17963.1 - 1.4e-19 70.0 0.2 2.6e-19 69.1 0.2 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_2 PF08028.11 KOS17963.1 - 8.8e-10 39.0 0.0 1.4e-09 38.3 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain XPG_I PF00867.18 KOS17964.1 - 5.5e-31 106.8 1.3 8.1e-31 106.2 0.0 1.9 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 KOS17964.1 - 7.6e-19 68.1 0.0 7.6e-19 68.1 0.0 1.9 2 0 0 2 2 2 1 XPG N-terminal domain 5_3_exonuc PF01367.20 KOS17964.1 - 1.2e-05 25.8 0.2 4.6e-05 23.9 0.0 2.1 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 KOS17964.1 - 0.023 15.3 0.0 0.048 14.3 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain DSBA PF01323.20 KOS17965.1 - 2.4e-16 60.1 0.0 8.5e-16 58.3 0.0 1.7 1 1 0 1 1 1 1 DSBA-like thioredoxin domain adh_short PF00106.25 KOS17966.1 - 5.2e-29 101.1 0.0 1.8e-20 73.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS17966.1 - 3.1e-23 82.5 0.3 2e-18 66.8 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS17966.1 - 0.0032 17.4 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS17966.1 - 0.096 12.1 0.0 0.19 11.1 0.0 1.5 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 KOS17966.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.4 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Pkinase PF00069.25 KOS17967.1 - 1.5e-62 211.3 0.0 1.9e-62 211.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS17967.1 - 4.1e-35 121.3 0.0 5.3e-35 120.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS17967.1 - 0.0013 18.1 0.0 0.0032 16.9 0.0 1.7 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 KOS17967.1 - 0.085 12.8 0.9 0.3 11.0 0.8 2.0 1 1 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOS17967.1 - 0.15 10.8 0.0 0.23 10.2 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOS17967.1 - 0.17 11.2 0.1 0.31 10.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3138 PF11336.8 KOS17967.1 - 0.92 8.0 4.4 1.3 7.5 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) ABC_tran_CTD PF16326.5 KOS17968.1 - 0.00024 21.3 8.2 0.00024 21.3 8.2 5.5 2 1 3 7 7 7 1 ABC transporter C-terminal domain Occludin_ELL PF07303.13 KOS17968.1 - 0.044 14.5 2.7 0.044 14.5 2.7 4.7 3 1 2 5 5 5 0 Occludin homology domain DUF4239 PF14023.6 KOS17968.1 - 0.29 10.8 8.5 0.19 11.5 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4239) HiaBD2 PF15403.6 KOS17968.1 - 0.44 11.0 3.0 3.5 8.1 0.4 3.6 4 0 0 4 4 4 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) APG6_N PF17675.1 KOS17968.1 - 3.7 8.1 56.1 0.85 10.2 21.0 4.7 2 1 3 5 5 5 0 Apg6 coiled-coil region 4HBT PF03061.22 KOS17969.1 - 2.7e-10 40.5 0.0 4.1e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily 4HBT_3 PF13622.6 KOS17969.1 - 0.032 14.5 0.1 0.052 13.8 0.1 1.4 1 1 0 1 1 1 0 Thioesterase-like superfamily DUF4442 PF14539.6 KOS17969.1 - 0.098 12.8 0.0 0.21 11.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) NAD_binding_4 PF07993.12 KOS17970.1 - 2e-23 82.9 0.0 2.9e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Male sterility protein FAD_binding_7 PF03441.14 KOS17971.1 - 1.4e-70 236.9 0.1 1.9e-70 236.5 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase DNA_photolyase PF00875.18 KOS17971.1 - 6.3e-38 130.4 0.2 2.3e-37 128.5 0.2 1.8 2 0 0 2 2 2 1 DNA photolyase p12I PF12233.8 KOS17971.1 - 0.098 13.2 0.0 18 5.9 0.0 2.4 2 0 0 2 2 2 0 Human adult T cell leukemia/lymphoma virus protein MutS_V PF00488.21 KOS17972.1 - 6.6e-83 277.4 0.1 1e-82 276.8 0.1 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOS17972.1 - 1.6e-36 126.3 0.1 1.1e-35 123.6 0.0 2.4 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 KOS17972.1 - 4.1e-24 85.4 1.0 7.8e-23 81.3 0.0 3.1 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 KOS17972.1 - 2.2e-13 50.3 3.6 3.3e-13 49.8 0.9 2.8 3 0 0 3 3 3 1 MutS family domain IV Com_YlbF PF06133.11 KOS17972.1 - 0.042 14.4 0.4 0.56 10.8 0.1 3.1 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA AAA_27 PF13514.6 KOS17972.1 - 0.071 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Tim17 PF02466.19 KOS17973.1 - 0.00044 20.6 8.2 0.0094 16.3 7.4 2.5 1 1 1 2 2 2 2 Tim17/Tim22/Tim23/Pmp24 family tRNA_m1G_MT PF01746.21 KOS17974.1 - 1.3e-26 93.5 0.0 1.8e-18 67.0 0.0 2.2 2 0 0 2 2 2 2 tRNA (Guanine-1)-methyltransferase ORC_WH_C PF18137.1 KOS17974.1 - 8.7 6.4 8.3 0.49 10.5 1.1 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DNA_primase_S PF01896.19 KOS17975.1 - 4.4e-63 212.5 0.3 6.1e-63 212.0 0.3 1.2 1 0 0 1 1 1 1 DNA primase small subunit Response_reg PF00072.24 KOS17976.1 - 7e-24 84.2 0.0 2.2e-23 82.6 0.0 1.9 2 0 0 2 2 2 1 Response regulator receiver domain HSF_DNA-bind PF00447.17 KOS17976.1 - 4.5e-11 43.2 0.2 1e-10 42.1 0.2 1.6 1 0 0 1 1 1 1 HSF-type DNA-binding YabA PF06156.13 KOS17976.1 - 3.2 8.4 9.0 0.095 13.3 2.3 1.8 2 0 0 2 2 2 0 Initiation control protein YabA CENP-H PF05837.12 KOS17976.1 - 4 7.9 9.4 0.089 13.2 2.2 1.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) GTP_EFTU PF00009.27 KOS17977.1 - 4.1e-33 114.6 5.7 1.8e-31 109.2 5.7 2.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOS17977.1 - 8.7e-28 96.5 0.2 3.2e-27 94.7 0.2 2.0 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 KOS17977.1 - 1.9e-10 40.8 0.8 5.7e-10 39.3 0.2 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS17977.1 - 9.5e-07 28.9 2.0 3.2e-05 23.9 0.2 2.6 1 1 1 2 2 2 1 RsgA GTPase Arf PF00025.21 KOS17977.1 - 1.2e-05 24.9 0.0 2.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU_D2 PF03144.25 KOS17977.1 - 2.6e-05 24.5 2.4 0.11 12.8 0.3 3.2 3 0 0 3 3 3 2 Elongation factor Tu domain 2 FeoB_N PF02421.18 KOS17977.1 - 8.8e-05 22.1 0.5 0.00024 20.7 0.5 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 KOS17977.1 - 0.00031 20.2 0.3 0.00092 18.7 0.3 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 KOS17977.1 - 0.00087 19.5 0.1 0.0022 18.2 0.1 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 KOS17977.1 - 0.0012 18.6 0.2 0.0039 17.0 0.2 1.9 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation IF2_N PF04760.15 KOS17977.1 - 0.0016 18.2 0.0 0.0034 17.2 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor IF-2, N-terminal region DUF5567 PF17722.1 KOS17977.1 - 0.0029 17.5 0.2 0.0074 16.2 0.2 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5567) GTP_EFTU_D4 PF14578.6 KOS17977.1 - 0.014 15.3 2.2 0.066 13.1 0.3 2.7 3 0 0 3 3 2 0 Elongation factor Tu domain 4 ATP_bind_1 PF03029.17 KOS17977.1 - 0.039 13.7 0.0 0.16 11.7 0.0 2.2 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein DBINO PF13892.6 KOS17977.1 - 0.35 11.2 5.9 0.93 9.8 5.9 1.7 1 0 0 1 1 1 0 DNA-binding domain Ribo_biogen_C PF04034.13 KOS17978.1 - 4.6e-50 168.6 0.0 6.5e-50 168.1 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 KOS17978.1 - 2.2e-12 46.5 1.0 5.1e-12 45.4 1.0 1.6 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Nop53 PF07767.11 KOS17978.1 - 0.13 11.6 15.2 0.008 15.6 9.7 1.6 1 1 1 2 2 2 0 Nop53 (60S ribosomal biogenesis) AIM24 PF01987.17 KOS17979.1 - 9.2e-47 159.4 0.0 1.2e-46 159.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 DUF915 PF06028.11 KOS17979.1 - 0.036 13.4 0.1 0.049 13.0 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Kinesin PF00225.23 KOS17980.1 - 9.2e-82 274.6 0.0 9.2e-82 274.6 0.0 1.6 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOS17980.1 - 2.6e-22 79.4 0.0 6.8e-22 78.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding HHH_3 PF12836.7 KOS17980.1 - 0.0083 16.4 0.0 0.033 14.4 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 KOS17980.1 - 0.0084 16.7 0.1 0.16 12.6 0.0 2.5 2 0 0 2 2 2 1 Helix-hairpin-helix domain TPR_15 PF13429.6 KOS17980.1 - 0.027 13.7 0.3 0.2 10.9 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat RAP1 PF07218.11 KOS17980.1 - 1 7.6 10.6 1.7 6.8 10.6 1.3 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) eIF-3c_N PF05470.12 KOS17982.1 - 0.035 12.4 6.1 5.8 5.1 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SAPS PF04499.15 KOS17982.1 - 0.1 11.4 1.5 0.2 10.4 1.5 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SDA1 PF05285.12 KOS17982.1 - 0.69 9.3 20.9 1 8.7 20.9 1.2 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 KOS17982.1 - 4.1 7.3 5.1 8.2 6.3 5.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain BUD22 PF09073.10 KOS17982.1 - 5.3 6.3 21.2 8.2 5.6 21.2 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 KOS17982.1 - 7.4 4.6 25.4 11 4.0 25.4 1.1 1 0 0 1 1 1 0 Nop14-like family GFA PF04828.14 KOS17983.1 - 0.026 14.9 0.4 0.046 14.1 0.0 1.6 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme AMP-binding PF00501.28 KOS17984.1 - 1.5e-72 244.5 0.0 1.8e-72 244.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS17984.1 - 2.2e-19 70.2 0.1 5.5e-19 68.9 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain OKR_DC_1_N PF03709.15 KOS17984.1 - 0.058 13.7 0.0 0.33 11.2 0.0 2.2 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Ifi-6-16 PF06140.13 KOS17984.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Interferon-induced 6-16 family Glyco_hydro_1 PF00232.18 KOS17986.1 - 2.4e-139 464.6 0.0 2.9e-139 464.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 ERCC3_RAD25_C PF16203.5 KOS17987.1 - 2.5e-121 403.5 0.2 5e-121 402.6 0.2 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 KOS17987.1 - 2.6e-34 118.1 0.0 3e-33 114.7 0.0 2.7 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS17987.1 - 6.6e-16 58.8 0.0 1.3e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOS17987.1 - 7.7e-12 45.5 0.1 2.6e-11 43.9 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 KOS17987.1 - 1.1e-07 31.0 0.0 1.3e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-CHY PF05495.12 KOS17988.1 - 2.6e-12 47.1 22.2 4.9e-12 46.2 22.2 1.4 1 0 0 1 1 1 1 CHY zinc finger zf-RRPl_C4 PF17026.5 KOS17988.1 - 0.012 15.7 2.5 0.012 15.7 2.5 2.1 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zinc_ribbon_9 PF14369.6 KOS17988.1 - 0.63 10.4 10.3 0.24 11.7 4.5 2.6 1 1 1 2 2 2 0 zinc-ribbon C1_4 PF07975.12 KOS17988.1 - 1.4 9.3 16.3 3.1 8.1 0.4 2.8 1 1 2 3 3 3 0 TFIIH C1-like domain zinc_ribbon_4 PF13717.6 KOS17988.1 - 6.8 6.7 14.1 1.6 8.7 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain VPS9 PF02204.18 KOS17989.1 - 1.1e-23 83.4 0.0 2.3e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF5601 PF18151.1 KOS17989.1 - 0.051 13.9 0.0 0.15 12.4 0.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5601) Integrase_Zn PF02022.19 KOS17989.1 - 0.052 13.5 0.2 0.11 12.4 0.2 1.6 1 0 0 1 1 1 0 Integrase Zinc binding domain K_oxygenase PF13434.6 KOS17989.1 - 0.19 10.9 2.0 0.74 8.9 2.0 1.8 1 1 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) TrkH PF02386.16 KOS17990.1 - 1.5e-136 455.8 3.0 1.5e-136 455.8 3.0 1.5 2 0 0 2 2 2 1 Cation transport protein PWI PF01480.17 KOS17991.1 - 8.2e-08 32.5 0.0 1.5e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 PWI domain RRM_1 PF00076.22 KOS17991.1 - 9.8e-08 31.7 0.1 0.00093 19.0 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH PF00642.24 KOS17991.1 - 3e-05 23.8 5.0 5.5e-05 23.0 5.0 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Nup35_RRM_2 PF14605.6 KOS17991.1 - 3.6e-05 23.7 0.0 0.0027 17.7 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KOS17991.1 - 0.019 14.8 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 Occluded RNA-recognition motif zf_CCCH_4 PF18345.1 KOS17991.1 - 0.024 14.7 3.9 0.046 13.8 3.9 1.5 1 0 0 1 1 1 0 Zinc finger domain PHM7_cyt PF14703.6 KOS17991.1 - 0.064 13.5 1.5 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter MTHFR PF02219.17 KOS17992.1 - 1.2e-114 382.4 0.0 1.7e-114 382.0 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase LRR_4 PF12799.7 KOS17993.1 - 1.7e-14 53.7 2.5 0.00058 20.2 0.1 4.1 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS17993.1 - 1.3e-11 44.0 8.5 1e-05 25.2 3.6 3.7 3 1 1 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 KOS17993.1 - 0.003 17.9 9.3 6.1 7.8 0.1 5.8 5 1 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 KOS17993.1 - 0.0031 17.0 0.3 0.077 12.5 0.1 2.4 2 1 1 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 KOS17993.1 - 0.089 12.9 11.1 1.3 9.3 0.0 5.2 4 1 1 5 5 5 0 Leucine Rich repeat Herpes_LMP1 PF05297.11 KOS17993.1 - 0.28 10.3 3.0 0.42 9.8 3.0 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Glyco_transf_90 PF05686.12 KOS17994.1 - 1.4e-11 43.9 0.5 0.0015 17.5 0.0 4.1 4 0 0 4 4 4 3 Glycosyl transferase family 90 Atg29_N PF18388.1 KOS17994.1 - 0.0018 18.0 0.0 0.0055 16.5 0.0 1.9 1 0 0 1 1 1 1 Atg29 N-terminal domain Hydrophobin PF01185.18 KOS17995.1 - 3.1e-12 47.0 7.4 3.9e-12 46.6 7.4 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Arginase PF00491.21 KOS17996.1 - 1.6e-74 251.0 0.4 1.8e-74 250.7 0.4 1.0 1 0 0 1 1 1 1 Arginase family Ribosomal_S13 PF00416.22 KOS17997.1 - 9.4e-17 61.6 1.6 1.2e-14 54.7 1.6 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 MARVEL PF01284.23 KOS17998.1 - 0.024 14.7 19.2 0.11 12.6 19.0 2.1 1 1 0 1 1 1 0 Membrane-associating domain RhoGAP PF00620.27 KOS17999.1 - 1.6e-14 54.0 0.0 3.2e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 KOS17999.1 - 1.2e-12 47.9 0.1 7.2e-11 42.2 0.0 2.6 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain DEP PF00610.21 KOS17999.1 - 2.5e-11 43.5 0.0 4.8e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) KIP1 PF07765.12 KOS17999.1 - 0.057 13.5 0.0 0.57 10.3 0.0 2.5 2 0 0 2 2 2 0 KIP1-like protein DUF1993 PF09351.10 KOS18000.1 - 4.5e-38 130.9 0.0 5.1e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Pox_T4_C PF04490.12 KOS18000.1 - 0.05 13.8 0.0 0.072 13.2 0.0 1.2 1 0 0 1 1 1 0 Poxvirus T4 protein, C terminus DUF501 PF04417.12 KOS18000.1 - 0.075 12.8 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF501) Trm112p PF03966.16 KOS18001.1 - 2.3e-16 60.1 0.2 3e-16 59.8 0.2 1.2 1 0 0 1 1 1 1 Trm112p-like protein DUF1479 PF07350.12 KOS18002.1 - 3.7e-154 513.5 0.0 4.3e-154 513.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1479) Pro_isomerase PF00160.21 KOS18003.1 - 7.7e-49 166.0 0.6 1e-48 165.6 0.6 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD N-SET PF11764.8 KOS18004.1 - 2.7e-55 187.1 0.1 2.7e-55 187.1 0.1 2.2 2 1 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 KOS18004.1 - 1.3e-18 67.9 0.1 1.3e-18 67.9 0.1 3.4 2 2 0 2 2 2 1 SET domain Tropomyosin_1 PF12718.7 KOS18005.1 - 4.6e-48 163.0 34.3 6e-48 162.6 34.3 1.2 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 KOS18005.1 - 3.4e-08 33.2 31.6 8.1e-06 25.4 15.7 2.1 1 1 1 2 2 2 2 Tropomyosin CENP-F_leu_zip PF10473.9 KOS18005.1 - 0.0016 18.4 8.2 0.0016 18.4 8.2 3.0 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.9 KOS18005.1 - 0.0019 18.4 25.2 0.33 11.2 7.3 3.2 1 1 2 3 3 3 3 Predicted coiled-coil domain-containing protein BRE1 PF08647.11 KOS18005.1 - 0.0089 16.1 27.8 0.17 12.0 11.5 2.6 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase Spc29 PF17082.5 KOS18005.1 - 0.011 15.6 15.8 0.035 14.0 6.6 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 TANGO2 PF05742.12 KOS18005.1 - 0.017 15.2 7.1 0.022 14.8 6.7 1.5 1 1 0 1 1 1 0 Transport and Golgi organisation 2 CEP209_CC5 PF16574.5 KOS18005.1 - 0.022 14.9 29.2 0.24 11.6 12.6 2.9 1 1 2 3 3 3 0 Coiled-coil region of centrosome protein CE290 DUF4200 PF13863.6 KOS18005.1 - 0.023 15.1 36.6 0.16 12.4 17.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Cep57_MT_bd PF06657.13 KOS18005.1 - 0.032 14.7 1.7 0.032 14.7 1.7 3.3 2 2 1 3 3 2 0 Centrosome microtubule-binding domain of Cep57 HMMR_N PF15905.5 KOS18005.1 - 0.034 13.6 30.9 0.039 13.4 30.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Cep57_CLD_2 PF14197.6 KOS18005.1 - 0.036 14.1 1.9 0.036 14.1 1.9 4.3 2 2 2 4 4 4 0 Centrosome localisation domain of PPC89 DUF3450 PF11932.8 KOS18005.1 - 0.064 12.6 27.5 0.25 10.6 13.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 KOS18005.1 - 0.075 12.8 28.5 0.072 12.9 10.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ADIP PF11559.8 KOS18005.1 - 0.11 12.6 31.9 1.3 9.1 10.1 2.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 KOS18005.1 - 0.13 12.7 38.9 0.16 12.5 24.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 KOS18005.1 - 0.15 10.9 33.4 0.26 10.2 16.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein GAS PF13851.6 KOS18005.1 - 0.19 11.0 34.2 0.45 9.8 20.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4686 PF15742.5 KOS18005.1 - 0.23 10.5 36.1 1.3 8.1 36.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) Lebercilin PF15619.6 KOS18005.1 - 0.35 10.5 35.0 2 8.0 20.5 2.4 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 KOS18005.1 - 0.49 10.6 32.7 1.6 8.9 15.7 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) EzrA PF06160.12 KOS18005.1 - 0.55 8.3 26.6 0.017 13.3 8.6 2.1 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA Jnk-SapK_ap_N PF09744.9 KOS18005.1 - 1 9.6 33.2 0.56 10.4 15.5 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 HOOK PF05622.12 KOS18005.1 - 1 7.4 30.2 1.5 6.9 30.2 1.1 1 0 0 1 1 1 0 HOOK protein DUF812 PF05667.11 KOS18005.1 - 1.5 7.6 30.9 2.7 6.8 17.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) HemX PF04375.14 KOS18005.1 - 1.5 8.0 23.6 1.1 8.4 7.4 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase HTH_Tnp_1 PF01527.20 KOS18005.1 - 1.8 8.9 10.7 22 5.5 5.3 3.2 2 2 0 2 2 2 0 Transposase SHE3 PF17078.5 KOS18005.1 - 2.5 7.7 27.5 0.86 9.3 7.2 2.2 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Fez1 PF06818.15 KOS18005.1 - 3.4 8.1 28.3 7.1 7.0 12.7 2.0 1 1 1 2 2 2 0 Fez1 bZIP_1 PF00170.21 KOS18005.1 - 4.1 7.6 25.9 1.3 9.2 1.6 4.4 3 1 0 3 3 3 0 bZIP transcription factor Fib_alpha PF08702.10 KOS18005.1 - 4.4 7.5 20.2 0.83 9.8 5.7 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 KOS18005.1 - 4.5 7.4 36.2 0.41 10.7 11.0 3.1 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain Prefoldin_2 PF01920.20 KOS18005.1 - 4.8 7.2 34.6 0.53 10.3 6.2 3.8 2 1 1 3 3 3 0 Prefoldin subunit AAA_13 PF13166.6 KOS18005.1 - 4.8 5.7 25.9 13 4.3 25.9 1.6 1 1 0 1 1 1 0 AAA domain DUF1664 PF07889.12 KOS18005.1 - 5.6 7.0 16.8 3.1 7.9 5.0 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4201 PF13870.6 KOS18005.1 - 5.6 6.7 31.8 1.8 8.3 24.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) ERM PF00769.19 KOS18005.1 - 6.4 6.5 36.9 10 5.9 16.4 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family HAUS-augmin3 PF14932.6 KOS18005.1 - 6.5 6.2 30.0 0.17 11.4 12.1 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 E2F_CC-MB PF16421.5 KOS18005.1 - 6.7 7.2 22.7 0.45 10.9 2.9 3.2 1 1 2 3 3 3 0 E2F transcription factor CC-MB domain DUF3584 PF12128.8 KOS18005.1 - 7 4.0 28.5 8.9 3.7 28.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF16 PF01519.16 KOS18005.1 - 8 7.0 23.2 8.3 7.0 9.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 FUSC PF04632.12 KOS18005.1 - 9.1 4.7 7.6 10 4.5 7.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4202 PF13875.6 KOS18006.1 - 5.4e-31 107.9 0.1 6.1e-31 107.8 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4202) PPR_2 PF13041.6 KOS18008.1 - 1e-42 144.1 6.0 1.6e-08 34.6 0.0 13.7 11 4 4 15 15 15 7 PPR repeat family PPR_3 PF13812.6 KOS18008.1 - 1.1e-24 86.3 0.0 0.0055 16.8 0.0 9.2 8 2 2 10 10 10 9 Pentatricopeptide repeat domain PPR PF01535.20 KOS18008.1 - 2.5e-23 80.7 19.3 0.0026 17.9 0.0 13.3 16 0 0 16 16 16 5 PPR repeat PPR_1 PF12854.7 KOS18008.1 - 1.3e-22 79.1 1.3 2.1e-07 30.5 0.0 10.7 11 0 0 11 11 11 3 PPR repeat PPR_long PF17177.4 KOS18008.1 - 1.1e-15 57.6 10.3 0.00034 20.0 0.0 7.1 3 2 3 7 7 7 5 Pentacotripeptide-repeat region of PRORP RPM2 PF08579.11 KOS18008.1 - 6.2e-07 29.8 0.0 0.00017 22.0 0.0 4.1 5 0 0 5 5 5 1 Mitochondrial ribonuclease P subunit (RPM2) GPP34 PF05719.11 KOS18008.1 - 0.0016 18.5 0.1 0.0063 16.6 0.0 2.1 2 0 0 2 2 2 1 Golgi phosphoprotein 3 (GPP34) ECSIT PF06239.11 KOS18008.1 - 0.084 12.0 0.1 8.4 5.4 0.0 3.2 3 0 0 3 3 3 0 Evolutionarily conserved signalling intermediate in Toll pathway GHMP_kinases_N PF00288.26 KOS18009.1 - 2.2e-16 59.8 2.2 2.2e-16 59.8 2.2 2.8 1 1 1 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOS18009.1 - 7.7e-09 35.8 0.6 2.1e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal DEAD PF00270.29 KOS18010.1 - 3.4e-43 147.4 0.0 5.5e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS18010.1 - 2.2e-19 69.8 0.0 7e-19 68.2 0.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOS18010.1 - 2.1e-16 59.9 0.0 4e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOS18010.1 - 0.00085 19.4 0.0 0.0017 18.4 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Alkyl_sulf_dimr PF14863.6 KOS18011.1 - 3.2e-54 183.2 0.0 6.9e-54 182.1 0.0 1.6 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 KOS18011.1 - 5.7e-31 107.4 0.0 9.9e-31 106.6 0.0 1.4 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal Lactamase_B PF00753.27 KOS18011.1 - 6.6e-26 91.5 0.0 1.5e-25 90.4 0.0 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOS18011.1 - 9.9e-06 25.2 0.0 3.3e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Beta-lactamase superfamily domain TPR_16 PF13432.6 KOS18011.1 - 0.059 14.0 0.1 0.14 12.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Senescence PF06911.12 KOS18012.1 - 0.00087 19.6 4.7 0.0013 19.0 4.7 1.3 1 0 0 1 1 1 1 Senescence-associated protein Spt20 PF12090.8 KOS18012.1 - 1.4 8.5 9.7 1.6 8.3 9.7 1.1 1 0 0 1 1 1 0 Spt20 family tRNA-synt_2 PF00152.20 KOS18013.1 - 1.8e-88 296.7 0.1 2.4e-88 296.2 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOS18013.1 - 3.5e-09 36.5 0.1 6.1e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain HIN PF02760.15 KOS18013.1 - 0.03 14.0 0.0 0.05 13.3 0.0 1.3 1 0 0 1 1 1 0 HIN-200/IF120x domain Ten1_2 PF15490.6 KOS18013.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Telomere-capping, CST complex subunit GTP_EFTU PF00009.27 KOS18014.1 - 5.6e-52 176.1 0.0 8.6e-52 175.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 KOS18014.1 - 7.8e-20 70.8 0.0 1.6e-19 69.7 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOS18014.1 - 1.2e-12 47.7 0.0 1.4e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOS18014.1 - 2.4e-06 27.8 0.0 7.4e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 HBB PF06777.11 KOS18014.1 - 0.1 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Helical and beta-bridge domain COPI_assoc PF08507.10 KOS18015.1 - 3.2e-33 114.6 8.6 3.6e-33 114.4 8.6 1.0 1 0 0 1 1 1 1 COPI associated protein Cytochrom_B558a PF05038.13 KOS18015.1 - 0.098 12.2 0.6 0.17 11.5 0.6 1.4 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit Cg6151-P PF10233.9 KOS18015.1 - 1.5 9.2 9.5 3.7 7.9 9.5 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DUF2583 PF10762.9 KOS18015.1 - 2.7 8.4 5.6 7.8 7.0 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2583) PGPGW PF09656.10 KOS18015.1 - 5.4 6.6 15.0 8.2 6.0 0.0 3.7 4 0 0 4 4 4 0 Putative transmembrane protein (PGPGW) SUN PF03856.13 KOS18017.1 - 1.6e-75 253.7 8.8 2.6e-75 253.0 8.8 1.3 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Utp14 PF04615.13 KOS18017.1 - 1.9 7.0 15.2 2.4 6.6 15.2 1.0 1 0 0 1 1 1 0 Utp14 protein SOG2 PF10428.9 KOS18017.1 - 2.1 7.5 31.8 3 6.9 31.8 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein LAP1C PF05609.12 KOS18017.1 - 6.4 5.8 18.1 8.6 5.3 18.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Fungal_trans PF04082.18 KOS18018.1 - 1.3e-05 24.4 0.0 2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Mannosidase_ig PF17786.1 KOS18019.1 - 1.2e-16 61.1 0.1 4.8e-14 52.7 0.0 2.6 2 0 0 2 2 2 2 Mannosidase Ig/CBM-like domain Glyco_hydro_2 PF00703.21 KOS18019.1 - 5.5e-12 46.3 0.0 1.4e-11 45.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Ig_mannosidase PF17753.1 KOS18019.1 - 2.5e-05 24.0 0.0 6.2e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Ig-fold domain Glyco_hydro_2_N PF02837.18 KOS18019.1 - 0.00055 19.9 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_C PF02836.17 KOS18019.1 - 0.024 13.7 0.1 0.057 12.5 0.1 1.6 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain SMN PF06003.12 KOS18020.1 - 0.21 10.8 5.7 0.25 10.6 5.7 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) 2-Hacid_dh_C PF02826.19 KOS18021.1 - 1.4e-47 161.3 0.0 7.7e-47 158.9 0.0 2.0 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOS18021.1 - 1.4e-07 31.3 0.0 1.4e-07 31.3 0.0 1.2 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOS18021.1 - 0.016 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Gp_dh_N PF00044.24 KOS18021.1 - 0.13 12.7 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain NPP1 PF05630.11 KOS18022.1 - 1.4e-05 25.4 3.8 0.00036 20.7 3.8 2.2 1 1 0 1 1 1 1 Necrosis inducing protein (NPP1) Sugar_tr PF00083.24 KOS18023.1 - 6.9e-70 236.1 20.7 9.2e-70 235.7 20.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS18023.1 - 7.9e-17 61.2 35.7 1.6e-16 60.2 35.7 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily PP28 PF10252.9 KOS18024.1 - 6.2e-26 90.7 14.3 6.2e-26 90.7 14.3 3.2 2 1 1 3 3 3 2 Casein kinase substrate phosphoprotein PP28 CoA_trans PF01144.23 KOS18025.1 - 2.5e-99 331.1 0.8 1.9e-59 200.7 0.1 2.0 2 0 0 2 2 2 2 Coenzyme A transferase Sugar_tr PF00083.24 KOS18026.1 - 3.2e-47 161.4 18.5 4.5e-43 147.8 3.9 2.5 1 1 2 3 3 3 2 Sugar (and other) transporter MFS_1 PF07690.16 KOS18026.1 - 0.52 9.2 40.7 0.031 13.2 14.0 3.2 1 1 3 4 4 4 0 Major Facilitator Superfamily SMAP PF15477.6 KOS18029.1 - 8.2e-12 45.9 2.4 8.2e-12 45.9 2.4 5.0 2 1 0 2 2 2 1 Small acidic protein family AF-4 PF05110.13 KOS18029.1 - 0.57 8.2 55.9 0.9 7.5 55.9 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Collagen PF01391.18 KOS18031.1 - 0.0016 18.2 6.4 0.0042 16.8 6.4 1.6 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) CLASP_N PF12348.8 KOS18032.1 - 3.2e-121 403.0 0.0 2.2e-87 292.4 0.0 2.5 2 0 0 2 2 2 2 CLASP N terminal RhoGAP PF00620.27 KOS18033.1 - 8.1e-46 155.6 2.7 1.1e-45 155.1 0.0 2.4 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 KOS18033.1 - 7.7e-14 51.7 16.5 2.7e-09 37.1 1.6 2.4 2 0 0 2 2 2 2 LIM domain Desulfoferrod_N PF06397.12 KOS18033.1 - 0.079 12.6 6.5 5.6 6.7 0.6 3.5 2 1 1 3 3 3 0 Desulfoferrodoxin, N-terminal domain Cytochrom_CIII PF02085.16 KOS18033.1 - 8.8 6.7 8.3 28 5.1 8.3 1.8 1 0 0 1 1 1 0 Class III cytochrome C family Zn-ribbon_8 PF09723.10 KOS18033.1 - 9 6.5 19.2 1.5 9.0 1.1 4.2 3 1 2 5 5 5 0 Zinc ribbon domain rRNA_processing PF08524.11 KOS18034.1 - 6.2e-07 29.6 20.6 7.6e-07 29.3 20.6 1.1 1 0 0 1 1 1 1 rRNA processing DUF3043 PF11241.8 KOS18034.1 - 1.4 8.9 17.4 2.8 7.9 17.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Presenilin PF01080.17 KOS18034.1 - 5.5 5.6 10.4 6.9 5.3 10.4 1.0 1 0 0 1 1 1 0 Presenilin DUF4210 PF13915.6 KOS18035.1 - 1.1e-32 112.4 0.0 3e-32 111.0 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4210) Chromosome_seg PF13889.6 KOS18035.1 - 2.5e-24 85.2 0.2 4.7e-24 84.3 0.2 1.5 1 0 0 1 1 1 1 Chromosome segregation during meiosis PPR_2 PF13041.6 KOS18036.1 - 1.5e-13 50.7 7.8 0.0004 20.5 0.0 7.1 5 2 3 8 8 8 5 PPR repeat family PPR PF01535.20 KOS18036.1 - 1.6e-12 46.7 17.6 0.0033 17.6 0.1 8.4 10 0 0 10 10 10 4 PPR repeat PPR_long PF17177.4 KOS18036.1 - 1.3e-07 31.2 0.8 0.1 12.0 0.2 3.6 2 1 1 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 KOS18036.1 - 5e-07 29.7 0.1 0.025 14.6 0.0 4.3 4 1 2 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 KOS18036.1 - 0.00043 19.9 0.0 55 3.6 0.0 5.0 5 0 0 5 5 5 0 PPR repeat DUF1981 PF09324.10 KOS18036.1 - 0.099 12.5 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) PI3_PI4_kinase PF00454.27 KOS18037.1 - 4.1e-38 131.6 0.0 4.2e-37 128.3 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase NOA36 PF06524.12 KOS18037.1 - 0.012 14.9 1.7 0.11 11.8 0.0 2.1 2 0 0 2 2 2 0 NOA36 protein YqeY PF09424.10 KOS18038.1 - 3e-23 82.5 6.5 3.8e-23 82.1 6.5 1.0 1 0 0 1 1 1 1 Yqey-like protein Ribonuc_L-PSP PF01042.21 KOS18039.1 - 2.6e-28 98.4 0.0 2.9e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP TB2_DP1_HVA22 PF03134.19 KOS18040.1 - 3.8e-28 97.2 6.4 5.6e-28 96.7 6.4 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Cupin_1 PF00190.22 KOS18041.1 - 2.2e-43 147.5 0.0 4.8e-21 74.9 0.0 2.1 2 0 0 2 2 2 2 Cupin Cupin_2 PF07883.11 KOS18041.1 - 3.7e-28 97.1 1.0 5.9e-13 48.3 0.2 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 KOS18041.1 - 1.1e-09 37.8 0.2 0.0002 21.0 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF861) AraC_binding PF02311.19 KOS18041.1 - 3.7e-07 30.1 0.1 0.0002 21.3 0.0 2.5 2 0 0 2 2 2 2 AraC-like ligand binding domain 3-HAO PF06052.12 KOS18041.1 - 0.00093 18.9 0.0 0.09 12.4 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase ARD PF03079.14 KOS18041.1 - 0.0053 17.0 0.6 1.6 8.9 0.0 2.3 2 0 0 2 2 2 2 ARD/ARD' family MannoseP_isomer PF01050.18 KOS18041.1 - 0.0079 16.1 0.0 0.15 12.0 0.0 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase Cupin_7 PF12973.7 KOS18041.1 - 0.022 14.7 0.6 0.13 12.2 0.1 2.5 3 1 0 3 3 3 0 ChrR Cupin-like domain SLATT_fungal PF18142.1 KOS18042.1 - 0.83 9.7 4.0 1.5 8.9 4.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain Clathrin PF00637.20 KOS18043.1 - 1.2e-20 73.8 3.2 2.7e-20 72.7 1.4 2.6 3 1 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 KOS18043.1 - 0.0087 16.3 0.3 0.063 13.6 0.2 2.4 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 NBP1 PF08537.10 KOS18043.1 - 0.041 13.3 0.1 0.073 12.5 0.1 1.3 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 zf-RING_11 PF17123.5 KOS18043.1 - 0.064 13.0 2.5 0.14 11.9 2.5 1.6 1 0 0 1 1 1 0 RING-like zinc finger Vps39_2 PF10367.9 KOS18043.1 - 0.18 12.3 0.0 0.57 10.6 0.0 1.8 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 zf-RING_UBOX PF13445.6 KOS18043.1 - 5.3 7.1 7.1 0.18 11.9 0.2 2.0 2 0 0 2 2 2 0 RING-type zinc-finger GatB_N PF02934.15 KOS18044.1 - 8.1e-97 323.9 0.0 1e-96 323.5 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 KOS18044.1 - 4.7e-09 36.3 0.0 9.8e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 GatB domain YtxH PF12732.7 KOS18045.1 - 0.0025 18.3 23.6 0.042 14.4 14.4 3.2 1 1 1 2 2 2 2 YtxH-like protein Apolipoprotein PF01442.18 KOS18045.1 - 0.012 15.5 6.6 0.024 14.5 6.6 1.5 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Fzo_mitofusin PF04799.13 KOS18045.1 - 0.022 14.3 3.6 0.029 13.9 2.8 1.6 1 1 1 2 2 2 0 fzo-like conserved region DUF883 PF05957.13 KOS18045.1 - 0.04 14.5 14.2 1 10.0 1.4 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) ATG_C PF09333.11 KOS18045.1 - 0.044 14.1 2.1 4 7.8 0.1 2.1 2 0 0 2 2 2 0 Autophagy-related protein C terminal domain ISG65-75 PF11727.8 KOS18045.1 - 0.07 12.3 15.1 0.091 12.0 15.1 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein ApoLp-III PF07464.11 KOS18045.1 - 0.28 11.3 11.4 2.1 8.4 3.7 2.2 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TMPIT PF07851.13 KOS18045.1 - 0.56 9.4 6.1 0.63 9.2 6.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein Grg1 PF11034.8 KOS18045.1 - 0.64 10.3 26.6 0.65 10.3 7.0 3.0 2 1 0 2 2 2 0 Glucose-repressible protein Grg1 Prominin PF05478.11 KOS18045.1 - 0.93 7.4 3.0 0.96 7.3 3.0 1.1 1 0 0 1 1 1 0 Prominin Synaptobrevin PF00957.21 KOS18045.1 - 2.8 7.8 8.5 1.3 8.8 4.5 2.1 1 1 1 2 2 2 0 Synaptobrevin DUF2514 PF10721.9 KOS18045.1 - 6.4 6.8 15.9 3.5 7.6 11.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2514) Glyco_hydro_16 PF00722.21 KOS18046.1 - 3.5e-31 108.0 0.4 6.6e-31 107.1 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 Sec7 PF01369.20 KOS18047.1 - 4.7e-30 104.6 0.0 8.2e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Sec7 domain PH_9 PF15410.6 KOS18047.1 - 6.5e-19 68.5 0.0 1.6e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Nop14 PF04147.12 KOS18047.1 - 0.4 8.8 18.8 0.61 8.2 18.8 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 KOS18047.1 - 3 7.2 19.7 6 6.2 19.7 1.4 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 KOS18047.1 - 6.7 5.9 20.1 20 4.4 20.1 1.7 1 0 0 1 1 1 0 BUD22 Fungal_trans PF04082.18 KOS18048.1 - 2.9e-20 72.4 0.0 6.1e-20 71.4 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS18048.1 - 0.00024 21.2 3.6 0.00055 20.0 3.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_tr PF00083.24 KOS18049.1 - 3e-79 267.0 16.9 3.5e-79 266.8 16.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS18049.1 - 6.7e-32 110.8 49.9 8.2e-30 103.9 27.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily zf-C3HC4 PF00097.25 KOS18050.1 - 7.2e-09 35.4 1.7 2.5e-08 33.7 1.9 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS18050.1 - 2.2e-07 30.8 1.3 2.2e-07 30.8 1.3 1.7 2 0 0 2 2 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOS18050.1 - 1.9e-06 27.6 3.1 1.9e-06 27.6 3.1 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS18050.1 - 5.7e-06 26.6 5.0 1.5e-05 25.2 5.0 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KOS18050.1 - 2.5e-05 24.3 4.1 0.0001 22.4 4.1 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KOS18050.1 - 5.9e-05 22.9 1.8 8.3e-05 22.4 1.0 1.7 1 1 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 KOS18050.1 - 7.2e-05 22.7 3.8 0.00019 21.3 3.8 1.8 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOS18050.1 - 0.00041 20.1 4.5 0.0019 18.1 0.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 KOS18050.1 - 0.0043 17.1 2.0 0.025 14.7 1.2 2.1 2 0 0 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 KOS18050.1 - 0.15 11.9 4.4 1.7 8.6 4.4 2.2 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Macoilin PF09726.9 KOS18050.1 - 0.68 8.4 6.6 0.88 8.0 6.6 1.1 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 KOS18050.1 - 8.9 6.3 7.0 0.79 9.7 2.6 1.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Metallopep PF12044.8 KOS18051.1 - 6.9e-164 545.5 0.0 8.4e-164 545.2 0.0 1.0 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 KOS18051.1 - 4.1e-05 23.5 0.0 7.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Jacalin-like lectin domain Reprolysin_5 PF13688.6 KOS18051.1 - 0.064 13.4 0.4 0.12 12.6 0.4 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12 Reprolysin_3 PF13582.6 KOS18051.1 - 0.14 12.7 0.3 0.31 11.6 0.3 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like WD40 PF00400.32 KOS18053.1 - 1.8e-30 104.5 7.5 2.3e-07 31.4 0.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 KOS18053.1 - 2.1e-09 36.6 4.1 0.21 10.2 0.1 5.0 3 2 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOS18053.1 - 2.2e-09 37.5 0.0 0.093 13.0 0.0 4.7 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain HEPN_SAV2148 PF18725.1 KOS18053.1 - 0.018 14.4 0.1 0.034 13.6 0.1 1.4 1 0 0 1 1 1 0 SAV2148-like HEPN BBS2_Mid PF14783.6 KOS18053.1 - 0.039 14.0 0.0 0.8 9.8 0.0 3.1 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Seryl_tRNA_N PF02403.22 KOS18053.1 - 1.7 8.9 5.1 3.1 8.1 0.3 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Vps5 PF09325.10 KOS18054.1 - 1.1e-10 41.5 0.8 1.7e-10 40.9 0.8 1.2 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 KOS18054.1 - 1.7e-06 28.0 0.0 3.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 PX domain TPR_12 PF13424.6 KOS18054.1 - 0.0014 18.9 0.8 0.043 14.1 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat NST1 PF13945.6 KOS18054.1 - 0.024 14.7 1.8 0.038 14.1 1.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator TPR_1 PF00515.28 KOS18054.1 - 0.18 11.7 1.5 1 9.3 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18054.1 - 0.45 10.8 2.1 8.2 6.8 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BCIP PF13862.6 KOS18055.1 - 2.2e-65 220.3 0.0 2.7e-65 220.0 0.0 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein NB-ARC PF00931.22 KOS18055.1 - 0.12 11.5 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Glyco_hydro_2_N PF02837.18 KOS18056.1 - 2.8e-13 50.1 0.0 7.1e-13 48.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 KOS18056.1 - 6.2e-10 39.7 0.0 1.7e-09 38.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 KOS18056.1 - 8.6e-08 31.6 0.0 2.7e-07 30.0 0.0 1.7 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain BetaGal_dom4_5 PF13364.6 KOS18056.1 - 0.0025 18.4 0.5 0.0078 16.8 0.2 1.9 2 0 0 2 2 2 1 Beta-galactosidase jelly roll domain Cadherin-like PF12733.7 KOS18056.1 - 0.24 11.9 1.4 13 6.4 0.0 2.8 3 0 0 3 3 3 0 Cadherin-like beta sandwich domain bZIP_1 PF00170.21 KOS18057.1 - 2.9e-08 33.7 13.5 4.6e-08 33.0 13.5 1.3 1 0 0 1 1 1 1 bZIP transcription factor PAP1 PF08601.10 KOS18057.1 - 7.9e-07 29.1 9.7 2.4e-05 24.3 0.0 2.1 1 1 1 2 2 2 2 Transcription factor PAP1 bZIP_Maf PF03131.17 KOS18057.1 - 1.2e-05 25.7 6.0 1.8e-05 25.2 6.0 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor ERM PF00769.19 KOS18057.1 - 0.0006 19.7 3.7 0.00075 19.4 3.7 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Rootletin PF15035.6 KOS18057.1 - 0.0068 16.5 4.3 0.0094 16.0 4.3 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion SHE3 PF17078.5 KOS18057.1 - 0.0069 16.1 4.7 0.01 15.6 4.7 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 V_ATPase_I PF01496.19 KOS18057.1 - 0.023 12.7 2.7 0.029 12.3 2.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 KOS18057.1 - 0.05 13.7 15.9 0.083 13.0 15.3 1.6 1 1 0 1 1 1 0 Basic region leucine zipper PRKCSH-like PF12999.7 KOS18057.1 - 0.14 12.0 0.9 0.22 11.3 0.9 1.3 1 0 0 1 1 1 0 Glucosidase II beta subunit-like APG6_N PF17675.1 KOS18057.1 - 0.29 11.7 9.2 0.47 11.0 9.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region UPF0242 PF06785.11 KOS18057.1 - 0.41 10.7 5.9 0.64 10.1 5.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Glutaredoxin2_C PF04399.13 KOS18057.1 - 0.41 10.5 2.1 0.9 9.4 2.1 1.5 1 0 0 1 1 1 0 Glutaredoxin 2, C terminal domain Glycos_transf_2 PF00535.26 KOS18058.1 - 3.7e-22 78.9 0.0 2e-21 76.5 0.0 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOS18058.1 - 5.8e-10 39.5 0.2 2e-07 31.2 0.1 2.3 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 KOS18058.1 - 0.056 12.9 0.0 0.085 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KOS18058.1 - 0.067 13.7 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 SE PF08491.10 KOS18059.1 - 8.3e-84 280.9 0.0 1.1e-83 280.4 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 KOS18059.1 - 8.5e-10 38.4 1.4 3.9e-08 32.9 1.4 2.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS18059.1 - 5.6e-09 36.0 0.4 1.9e-07 31.0 0.2 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 KOS18059.1 - 7.2e-06 25.3 1.6 3.2e-05 23.2 1.6 1.8 1 1 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOS18059.1 - 9.4e-06 25.2 0.5 1.4e-05 24.7 0.1 1.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS18059.1 - 1.7e-05 24.1 0.2 2.6e-05 23.5 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOS18059.1 - 1.7e-05 24.9 0.2 3.4e-05 24.0 0.2 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOS18059.1 - 0.00014 21.2 0.0 0.00031 20.1 0.0 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 KOS18059.1 - 0.0004 19.7 0.1 0.002 17.4 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS18059.1 - 0.0016 18.9 1.8 0.016 15.8 0.1 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.16 KOS18059.1 - 0.004 16.8 0.1 0.0069 16.0 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 KOS18059.1 - 0.016 13.9 0.0 0.024 13.3 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 KOS18059.1 - 0.037 13.1 0.1 0.44 9.5 0.0 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein 3HCDH_N PF02737.18 KOS18059.1 - 0.084 12.7 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 KOS18059.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus AlaDh_PNT_C PF01262.21 KOS18059.1 - 0.13 11.5 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 KOS18059.1 - 0.17 11.9 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ThiF PF00899.21 KOS18059.1 - 0.22 10.9 0.0 1.6 8.1 0.0 2.0 2 0 0 2 2 2 0 ThiF family SMK-1 PF04802.15 KOS18060.1 - 6.5e-81 270.7 0.4 6.5e-81 270.7 0.4 1.9 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 CCSAP PF15748.5 KOS18060.1 - 0.32 11.1 10.0 0.53 10.4 10.0 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SDA1 PF05285.12 KOS18060.1 - 6 6.2 17.8 9.5 5.5 17.8 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS18060.1 - 6.4 4.9 8.7 10 4.3 8.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Rdx PF10262.9 KOS18062.1 - 4e-34 116.6 0.0 5.3e-34 116.2 0.0 1.2 1 0 0 1 1 1 1 Rdx family Metallophos PF00149.28 KOS18063.1 - 3.9e-40 138.5 0.1 5.2e-40 138.1 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOS18063.1 - 1e-22 80.3 2.4 1.4e-22 79.9 1.5 1.7 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Fungal_trans PF04082.18 KOS18064.1 - 5.6e-15 55.1 0.2 1.6e-14 53.6 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS18064.1 - 9.9e-05 22.4 8.8 0.0002 21.4 8.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dus PF01207.17 KOS18065.1 - 1e-56 192.3 0.0 2.9e-55 187.6 0.0 2.1 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) WSC PF01822.19 KOS18068.1 - 2e-39 133.7 27.8 9e-20 70.7 9.5 2.5 2 0 0 2 2 2 2 WSC domain PTN_MK_N PF05196.13 KOS18068.1 - 0.9 9.8 9.4 6.7 7.0 2.0 2.7 2 0 0 2 2 2 0 PTN/MK heparin-binding protein family, N-terminal domain zf-primase PF09329.11 KOS18068.1 - 2.5 8.0 7.4 7.1 6.5 0.9 2.5 2 0 0 2 2 2 0 Primase zinc finger PCI PF01399.27 KOS18069.1 - 8.5e-07 29.4 0.0 8.5e-07 29.4 0.0 2.6 3 0 0 3 3 3 1 PCI domain ubiquitin PF00240.23 KOS18070.1 - 1.1e-05 25.1 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family YukD PF08817.10 KOS18070.1 - 0.00041 21.0 0.0 0.00069 20.3 0.0 1.4 1 1 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD G-gamma PF00631.22 KOS18071.1 - 6.8e-24 83.7 0.0 8.7e-24 83.3 0.0 1.1 1 0 0 1 1 1 1 GGL domain PAS_4 PF08448.10 KOS18073.1 - 0.04 14.2 0.0 0.073 13.3 0.0 1.4 1 0 0 1 1 1 0 PAS fold End3 PF12761.7 KOS18074.1 - 1.4e-76 257.2 3.8 1.9e-76 256.7 3.8 1.2 1 0 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_4 PF12763.7 KOS18074.1 - 1.9e-47 159.5 0.0 5.9e-47 157.9 0.0 1.9 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 KOS18074.1 - 7.1e-07 28.3 0.3 1.6e-06 27.3 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 KOS18074.1 - 9.8e-06 25.9 0.1 5e-05 23.7 0.1 2.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 KOS18074.1 - 0.0024 17.7 0.1 0.0044 16.8 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 KOS18074.1 - 0.0039 17.0 0.3 0.018 14.9 0.3 2.1 2 0 0 2 2 2 1 EF-hand domain Drf_FH3 PF06367.16 KOS18074.1 - 0.13 11.8 4.9 2.2 7.8 0.3 2.5 2 0 0 2 2 2 0 Diaphanous FH3 Domain CSN5_C PF18323.1 KOS18074.1 - 1.5 9.8 4.2 1.1 10.2 1.0 2.4 3 0 0 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain UPF0242 PF06785.11 KOS18074.1 - 4.3 7.4 8.1 8.4 6.4 8.1 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ribonuclease_T2 PF00445.18 KOS18075.1 - 7.4e-36 124.1 0.0 1.1e-35 123.6 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Actin PF00022.19 KOS18076.1 - 2.9e-15 55.8 0.0 1.1e-12 47.3 0.0 2.6 3 0 0 3 3 3 2 Actin SURF6 PF04935.12 KOS18077.1 - 3.1e-49 167.5 35.7 3.1e-49 167.5 35.7 5.4 3 2 1 4 4 4 1 Surfeit locus protein 6 RRP14 PF15459.6 KOS18077.1 - 1.3e-15 57.8 0.7 1.3e-15 57.8 0.7 8.8 6 2 2 8 8 8 1 60S ribosome biogenesis protein Rrp14 Peptidase_C14 PF00656.22 KOS18078.1 - 1.7e-64 218.1 0.0 2.2e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 KOS18078.1 - 0.089 12.7 0.4 0.44 10.5 0.0 2.3 3 0 0 3 3 3 0 Raptor N-terminal CASPase like domain Acetyltransf_1 PF00583.25 KOS18079.1 - 8.6e-08 32.4 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOS18079.1 - 1.1e-06 29.0 0.0 1.7e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS18079.1 - 1.3e-06 28.4 0.0 3.4e-06 27.0 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS18079.1 - 0.092 12.7 0.1 0.35 10.8 0.1 1.9 1 1 0 1 1 1 0 FR47-like protein YccV-like PF08755.11 KOS18080.1 - 4.2e-05 24.0 0.2 6.7e-05 23.3 0.2 1.4 1 0 0 1 1 1 1 Hemimethylated DNA-binding protein YccV like Cnn_1N PF07989.11 KOS18081.1 - 7.8e-27 93.2 4.7 7.8e-27 93.2 4.7 16.5 7 3 6 14 14 14 1 Centrosomin N-terminal motif 1 PACT_coil_coil PF10495.9 KOS18081.1 - 1.5e-24 86.4 1.8 1.5e-24 86.4 1.8 6.4 6 1 0 6 6 6 1 Pericentrin-AKAP-450 domain of centrosomal targeting protein MAD PF05557.13 KOS18081.1 - 2.2e-06 26.3 108.2 4.2e-06 25.4 56.0 5.4 1 1 4 5 5 5 3 Mitotic checkpoint protein ATG16 PF08614.11 KOS18081.1 - 4.8e-06 26.9 16.9 4.8e-06 26.9 16.9 11.9 2 1 8 10 10 10 1 Autophagy protein 16 (ATG16) MscS_porin PF12795.7 KOS18081.1 - 0.00046 19.8 34.3 0.00046 19.8 34.3 10.0 2 1 7 9 9 9 2 Mechanosensitive ion channel porin domain Spc7 PF08317.11 KOS18081.1 - 0.00052 19.0 193.4 0.022 13.6 20.0 10.0 1 1 11 12 12 12 7 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 KOS18081.1 - 0.0013 18.8 10.9 0.0013 18.8 10.9 11.8 1 1 11 12 12 12 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 KOS18081.1 - 0.0019 18.1 32.1 0.0019 18.1 32.1 8.6 1 1 5 7 7 7 2 Ezrin/radixin/moesin family Fez1 PF06818.15 KOS18081.1 - 0.049 14.1 187.1 0.46 10.9 20.0 8.9 1 1 4 7 7 7 0 Fez1 Big_4 PF07532.11 KOS18082.1 - 0.011 15.5 0.9 1.3 8.8 0.0 3.6 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 4) I-set PF07679.16 KOS18082.1 - 0.012 15.7 0.3 7.4 6.7 0.1 4.5 5 0 0 5 5 5 0 Immunoglobulin I-set domain DUF1918 PF08940.11 KOS18082.1 - 0.1 12.2 2.8 25 4.6 0.1 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1918) ComFB PF10719.9 KOS18082.1 - 0.17 12.0 0.0 0.5 10.5 0.0 1.8 1 0 0 1 1 1 0 Late competence development protein ComFB Peptidase_C12 PF01088.21 KOS18083.1 - 1.2e-58 198.3 0.0 1.9e-58 197.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Asp PF00026.23 KOS18085.1 - 1.2e-109 366.5 0.0 1.5e-109 366.3 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS18085.1 - 3.6e-15 56.7 5.0 9.6e-14 52.0 2.5 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOS18085.1 - 2.7e-05 24.7 0.1 0.13 12.9 0.0 2.8 2 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 KOS18085.1 - 0.001 19.6 0.0 1.2 9.7 0.0 2.9 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease TAXi_C PF14541.6 KOS18085.1 - 0.014 15.2 0.0 0.13 12.0 0.0 2.4 2 1 0 2 2 2 0 Xylanase inhibitor C-terminal DUF155 PF02582.14 KOS18087.1 - 4.6e-44 150.6 0.0 6.1e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 CRAL_TRIO PF00650.20 KOS18088.1 - 2.7e-35 121.5 0.0 4e-35 120.9 0.0 1.3 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOS18088.1 - 1.1e-08 35.1 0.1 3.3e-08 33.6 0.1 1.8 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOS18088.1 - 0.00092 19.4 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Apt1 PF10351.9 KOS18089.1 - 0.15 10.9 2.0 0.15 10.9 2.0 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Chorion_2 PF03964.15 KOS18089.1 - 0.2 12.5 9.4 0.28 12.0 9.4 1.2 1 0 0 1 1 1 0 Chorion family 2 FAM104 PF15434.6 KOS18089.1 - 1.3 9.6 11.9 2.1 8.9 11.9 1.4 1 0 0 1 1 1 0 Family 104 SR-25 PF10500.9 KOS18089.1 - 2.4 7.7 22.1 3.2 7.3 22.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA PF00004.29 KOS18090.1 - 2.2e-45 154.3 0.7 1.4e-44 151.7 0.0 2.5 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOS18090.1 - 1.1e-10 41.2 0.1 7.6e-10 38.6 0.0 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 KOS18090.1 - 8.4e-09 35.5 0.4 2.7e-08 33.9 0.1 2.1 2 2 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOS18090.1 - 6.1e-08 33.0 0.0 1.3e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOS18090.1 - 1.7e-07 31.8 0.5 3.7e-05 24.2 0.0 2.9 2 2 1 3 3 3 1 AAA ATPase domain DUF815 PF05673.13 KOS18090.1 - 3.7e-06 26.3 0.0 8e-06 25.2 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 KOS18090.1 - 6.9e-05 23.1 2.7 0.0081 16.4 0.1 2.9 2 1 0 3 3 3 1 AAA domain RuvB_N PF05496.12 KOS18090.1 - 0.00038 20.2 0.0 0.0011 18.7 0.0 1.8 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_lid_3 PF17862.1 KOS18090.1 - 0.00038 20.2 0.0 0.00086 19.1 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_18 PF13238.6 KOS18090.1 - 0.00087 19.8 0.0 0.0027 18.3 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.6 KOS18090.1 - 0.00094 19.5 0.0 0.002 18.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KOS18090.1 - 0.0012 18.1 0.0 0.0024 17.1 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 KOS18090.1 - 0.0013 18.3 0.1 0.0078 15.7 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region RNA_helicase PF00910.22 KOS18090.1 - 0.0014 19.0 0.0 0.0031 17.9 0.0 1.6 1 0 0 1 1 1 1 RNA helicase TsaE PF02367.17 KOS18090.1 - 0.0016 18.4 0.0 0.024 14.7 0.0 2.2 1 1 1 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 KOS18090.1 - 0.002 18.2 0.1 0.0087 16.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 KOS18090.1 - 0.0026 17.7 0.0 0.012 15.5 0.0 2.0 2 0 0 2 2 2 1 NTPase NACHT PF05729.12 KOS18090.1 - 0.0027 17.7 0.5 0.11 12.4 0.0 3.3 4 0 0 4 4 4 1 NACHT domain AAA_30 PF13604.6 KOS18090.1 - 0.0053 16.5 0.9 0.014 15.2 0.1 2.1 2 1 0 2 2 2 1 AAA domain Viral_Hsp90 PF03225.14 KOS18090.1 - 0.0061 15.1 0.0 0.0098 14.4 0.0 1.2 1 0 0 1 1 1 1 Viral heat shock protein Hsp90 homologue AAA_3 PF07726.11 KOS18090.1 - 0.0065 16.3 0.0 0.02 14.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 KOS18090.1 - 0.0083 15.5 0.0 0.019 14.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOS18090.1 - 0.0088 16.2 0.0 0.02 15.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 KOS18090.1 - 0.011 15.2 0.0 0.54 9.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein IstB_IS21 PF01695.17 KOS18090.1 - 0.017 14.9 0.1 0.043 13.5 0.0 1.8 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 KOS18090.1 - 0.019 14.7 0.2 0.051 13.3 0.2 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 KOS18090.1 - 0.03 13.7 0.9 0.56 9.5 0.0 2.6 3 0 0 3 3 3 0 KaiC ATPase_2 PF01637.18 KOS18090.1 - 0.034 14.1 1.1 0.23 11.4 0.1 2.6 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 KOS18090.1 - 0.036 13.9 0.1 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOS18090.1 - 0.051 14.1 1.3 5.3 7.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 KOS18090.1 - 0.054 12.4 0.1 0.14 11.0 0.0 1.7 2 0 0 2 2 2 0 AFG1-like ATPase AAA_25 PF13481.6 KOS18090.1 - 0.063 12.8 1.1 0.26 10.9 0.1 2.3 2 1 1 3 3 3 0 AAA domain Bac_DnaA PF00308.18 KOS18090.1 - 0.068 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Bacterial dnaA protein Sigma54_activat PF00158.26 KOS18090.1 - 0.085 12.6 0.2 1.4 8.6 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 KOS18090.1 - 0.14 12.5 0.1 0.41 11.0 0.1 1.7 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOS18090.1 - 0.18 11.6 0.0 0.35 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Parvo_NS1 PF01057.17 KOS18090.1 - 0.2 10.7 0.0 0.39 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Folliculin PF11704.8 KOS18091.1 - 2.3e-57 193.8 0.0 2.3e-57 193.8 0.0 2.6 3 0 0 3 3 3 1 Vesicle coat protein involved in Golgi to plasma membrane transport Drc1-Sld2 PF11719.8 KOS18092.1 - 1.4e-88 298.4 11.5 1.4e-88 298.4 11.5 1.9 1 1 1 2 2 2 1 DNA replication and checkpoint protein DUF569 PF04601.13 KOS18092.1 - 0.13 11.9 0.2 0.29 10.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF569) BSP_II PF05432.11 KOS18092.1 - 0.69 9.6 29.6 0.18 11.5 16.8 2.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Nrap_D5 PF17406.2 KOS18093.1 - 4.9e-59 198.7 0.2 4.2e-58 195.7 0.2 2.3 2 0 0 2 2 2 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 KOS18093.1 - 4.5e-55 186.3 0.0 8e-55 185.5 0.0 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap_D2 PF17403.2 KOS18093.1 - 1.8e-51 173.9 0.5 5.8e-49 165.8 0.0 2.7 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap PF03813.14 KOS18093.1 - 3e-48 163.7 0.0 5.7e-48 162.8 0.0 1.5 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 KOS18093.1 - 6.2e-46 156.4 0.1 1.4e-45 155.2 0.1 1.6 1 0 0 1 1 1 1 Nrap protein domain 3 Nrap_D6 PF17407.2 KOS18093.1 - 4.4e-32 111.1 0.0 1.5e-31 109.4 0.0 2.0 2 0 0 2 2 2 1 Nrap protein domain 6 OAS1_C PF10421.9 KOS18093.1 - 0.027 14.0 0.1 0.14 11.6 0.1 2.0 2 0 0 2 2 2 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus DNA_methylase PF00145.17 KOS18095.1 - 3.9e-38 131.7 0.0 1.3e-26 93.8 0.0 2.1 1 1 1 2 2 2 2 C-5 cytosine-specific DNA methylase TFIIA PF03153.13 KOS18096.1 - 5e-06 26.8 17.8 8.4e-06 26.0 17.8 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 KOS18096.1 - 0.034 13.5 13.4 0.058 12.7 13.4 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 KOS18096.1 - 1.5 9.1 12.2 7.8 6.8 12.2 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF1168 PF06658.12 KOS18096.1 - 8.6 6.2 25.8 0.47 10.3 6.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) SEN1_N PF12726.7 KOS18097.1 - 1.7e-207 691.2 0.0 1.7e-207 691.2 0.0 1.5 2 0 0 2 2 2 1 SEN1 N terminal AAA_11 PF13086.6 KOS18097.1 - 1.5e-73 247.8 1.0 1.5e-73 247.8 1.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 KOS18097.1 - 6.2e-62 208.8 0.0 1.2e-61 207.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS18097.1 - 3.6e-08 33.8 0.2 2.3e-07 31.3 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS18097.1 - 5.3e-08 32.8 4.7 0.00012 21.9 0.3 3.7 3 0 0 3 3 3 2 AAA domain UvrD-helicase PF00580.21 KOS18097.1 - 2.1e-06 27.5 4.1 0.00011 21.9 0.1 3.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 KOS18097.1 - 7.7e-05 22.5 0.1 0.19 11.4 0.0 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOS18097.1 - 0.018 15.3 0.3 0.069 13.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain Glyco_hydro_61 PF03443.14 KOS18099.1 - 0.046 13.6 0.2 0.26 11.2 0.0 2.1 1 1 1 2 2 2 0 Glycosyl hydrolase family 61 Serglycin PF04360.12 KOS18099.1 - 0.47 10.4 1.9 1 9.3 1.9 1.5 1 0 0 1 1 1 0 Serglycin CPSase_L_D2 PF02786.17 KOS18100.1 - 3.9e-112 372.9 0.2 9.4e-84 280.1 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 KOS18100.1 - 5.3e-47 158.8 0.0 1.4e-46 157.4 0.0 1.8 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 KOS18100.1 - 1.1e-46 159.1 0.0 2.6e-46 157.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 KOS18100.1 - 4.2e-45 153.4 0.0 9.5e-45 152.2 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 KOS18100.1 - 5.2e-39 133.4 0.2 1.9e-38 131.5 0.0 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 KOS18100.1 - 1.8e-27 96.4 0.0 4.7e-27 95.0 0.0 1.8 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 KOS18100.1 - 5.3e-22 77.8 0.0 4.7e-21 74.8 0.0 2.7 3 0 0 3 3 3 1 MGS-like domain Dala_Dala_lig_C PF07478.13 KOS18100.1 - 4.7e-17 62.2 0.7 7e-08 32.3 0.1 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOS18100.1 - 1.1e-16 60.9 0.1 6.9e-09 35.5 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 KOS18100.1 - 6e-10 39.0 0.0 7.4e-05 22.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 KOS18100.1 - 1e-05 25.6 0.4 0.044 13.8 0.1 2.6 2 0 0 2 2 2 2 ATP-grasp domain Peptidase_C26 PF07722.13 KOS18100.1 - 1.2e-05 25.1 1.7 0.00076 19.3 0.2 3.0 2 1 0 2 2 2 1 Peptidase C26 RimK PF08443.11 KOS18100.1 - 0.00026 20.6 0.0 0.32 10.6 0.0 2.6 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.19 KOS18100.1 - 0.0005 19.9 0.5 1.2 8.9 0.1 3.1 3 0 0 3 3 3 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain DJ-1_PfpI PF01965.24 KOS18100.1 - 0.00059 19.7 1.2 0.18 11.6 0.0 4.0 4 0 0 4 4 3 1 DJ-1/PfpI family Cyclin_N PF00134.23 KOS18102.1 - 5.4e-05 22.9 0.0 0.0016 18.2 0.0 2.1 2 0 0 2 2 2 2 Cyclin, N-terminal domain Putative_PNPOx PF01243.20 KOS18103.1 - 4.9e-19 68.3 0.0 7.9e-19 67.6 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 KOS18103.1 - 1.3e-18 66.8 2.5 3.3e-18 65.5 1.9 2.0 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 KOS18103.1 - 0.005 17.4 0.0 0.037 14.6 0.0 2.1 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase adh_short PF00106.25 KOS18104.1 - 2.8e-86 288.0 8.8 9.3e-46 155.7 1.2 2.6 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS18104.1 - 2.1e-69 233.6 6.2 6.1e-37 127.4 0.9 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase MaoC_dehydratas PF01575.19 KOS18104.1 - 1.9e-31 108.2 0.0 4.5e-31 107.0 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain KR PF08659.10 KOS18104.1 - 9.5e-26 90.8 3.4 5.6e-12 45.9 0.4 2.5 2 0 0 2 2 2 2 KR domain MaoC_dehydrat_N PF13452.6 KOS18104.1 - 9.9e-07 29.0 0.0 0.025 14.7 0.0 3.2 3 0 0 3 3 3 2 N-terminal half of MaoC dehydratase THF_DHG_CYH_C PF02882.19 KOS18104.1 - 4e-05 23.0 0.7 0.2 11.0 0.2 2.5 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 3HCDH_N PF02737.18 KOS18104.1 - 0.25 11.2 6.4 5.2 6.9 0.6 2.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF543 PF04418.12 KOS18104.1 - 9 6.4 7.6 1.8 8.6 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF543) AAA_16 PF13191.6 KOS18105.1 - 2.5e-06 28.0 0.0 4.4e-06 27.2 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 KOS18105.1 - 7.2e-06 25.2 0.0 1.2e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 KOS18105.1 - 6.7e-05 22.6 0.0 9.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain HD_assoc PF13286.6 KOS18105.1 - 0.0041 17.6 0.0 0.021 15.4 0.0 2.0 2 0 0 2 2 2 1 Phosphohydrolase-associated domain KAP_NTPase PF07693.14 KOS18105.1 - 0.0059 15.9 0.0 0.0088 15.3 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain CbiA PF01656.23 KOS18105.1 - 0.012 15.7 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_18 PF13238.6 KOS18105.1 - 0.044 14.3 0.0 0.099 13.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS18105.1 - 0.047 13.6 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 KOS18105.1 - 0.048 13.6 0.0 0.071 13.0 0.0 1.2 1 0 0 1 1 1 0 NTPase MobB PF03205.14 KOS18105.1 - 0.06 13.2 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_31 PF13614.6 KOS18105.1 - 0.063 13.2 0.1 0.096 12.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 KOS18105.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase AAA_30 PF13604.6 KOS18105.1 - 0.12 12.1 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Torsin PF06309.11 KOS18105.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Torsin Zeta_toxin PF06414.12 KOS18105.1 - 0.22 10.8 0.0 0.34 10.2 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin Cation_efflux PF01545.21 KOS18106.1 - 4.3e-13 49.5 14.6 5.7e-13 49.0 14.6 1.1 1 0 0 1 1 1 1 Cation efflux family PIG-Y PF15159.6 KOS18107.1 - 1.6e-22 80.2 9.1 2.4e-22 79.6 9.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y UPF0688 PF15772.5 KOS18107.1 - 0.055 13.7 1.1 0.077 13.2 1.1 1.2 1 0 0 1 1 1 0 UPF0688 family DUF1218 PF06749.12 KOS18107.1 - 0.28 11.7 4.4 4.5 7.9 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1218) Enamelin PF15362.6 KOS18107.1 - 0.67 8.2 4.9 0.82 7.9 4.9 1.1 1 0 0 1 1 1 0 Enamelin Spb1_C PF07780.12 KOS18108.1 - 5.3e-84 281.1 15.9 5.3e-84 281.1 15.9 4.0 3 1 1 4 4 4 1 Spb1 C-terminal domain DUF3381 PF11861.8 KOS18108.1 - 4.2e-52 176.3 5.7 4.2e-52 176.3 5.7 4.7 4 1 1 5 5 5 1 Domain of unknown function (DUF3381) FtsJ PF01728.19 KOS18108.1 - 6.1e-49 166.5 0.0 1.1e-48 165.7 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase BT1 PF03092.16 KOS18108.1 - 1.6 6.9 3.2 3.3 5.8 3.2 1.5 1 0 0 1 1 1 0 BT1 family Dynamin_N PF00350.23 KOS18109.1 - 4.6e-44 150.4 0.0 8.7e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 KOS18109.1 - 4.3e-12 45.8 0.0 1.3e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 KOS18109.1 - 2.4e-06 27.6 0.1 8.9e-05 22.6 0.0 3.0 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_21 PF13304.6 KOS18109.1 - 0.059 13.2 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOS18109.1 - 0.065 13.6 0.5 0.27 11.6 0.1 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_15 PF13175.6 KOS18109.1 - 0.12 12.0 1.0 0.22 11.2 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain Sterol-sensing PF12349.8 KOS18110.1 - 3.3e-26 91.9 10.0 6e-26 91.1 10.0 1.4 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 KOS18110.1 - 6.2e-05 21.3 11.7 8.8e-05 20.8 11.7 1.1 1 0 0 1 1 1 1 Patched family Cupin_8 PF13621.6 KOS18111.1 - 3.8e-54 184.1 0.0 4.3e-54 183.9 0.0 1.0 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOS18111.1 - 0.0047 16.4 0.1 0.065 12.7 0.1 2.2 2 0 0 2 2 2 1 Cupin superfamily protein DHH PF01368.20 KOS18112.1 - 0.061 13.6 0.4 0.08 13.2 0.4 1.4 1 1 0 1 1 1 0 DHH family GFO_IDH_MocA PF01408.22 KOS18113.1 - 3.6e-17 63.3 0.0 6.6e-17 62.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 KOS18113.1 - 0.0026 18.2 0.0 0.0049 17.3 0.0 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 KOS18113.1 - 0.065 13.2 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase family, C-terminal alpha/beta domain AMP-binding PF00501.28 KOS18114.1 - 3.9e-75 253.1 0.0 8.4e-75 251.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme ketoacyl-synt PF00109.26 KOS18114.1 - 2.5e-74 250.1 0.2 4.4e-74 249.2 0.2 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Condensation PF00668.20 KOS18114.1 - 8.5e-54 182.9 0.0 9.4e-37 126.7 0.0 2.2 1 1 1 2 2 2 2 Condensation domain KR PF08659.10 KOS18114.1 - 1.8e-52 177.9 0.0 1.6e-51 174.8 0.1 2.5 2 0 0 2 2 2 1 KR domain PS-DH PF14765.6 KOS18114.1 - 1.5e-44 152.5 0.1 1.8e-43 148.9 0.0 2.5 2 0 0 2 2 2 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 KOS18114.1 - 4.9e-38 131.4 0.1 9.4e-38 130.5 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 KOS18114.1 - 1.6e-27 95.9 0.3 6.9e-27 93.8 0.0 2.3 3 0 0 3 3 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 KOS18114.1 - 1.7e-25 89.7 0.0 3.7e-24 85.3 0.0 2.4 1 1 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 KOS18114.1 - 2.2e-19 69.5 0.1 3.4e-09 36.9 0.0 2.9 2 0 0 2 2 2 2 Phosphopantetheine attachment site Methyltransf_12 PF08242.12 KOS18114.1 - 9.2e-14 52.0 0.0 3.3e-13 50.2 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain KAsynt_C_assoc PF16197.5 KOS18114.1 - 1.9e-13 50.9 0.0 7e-13 49.0 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_31 PF13847.6 KOS18114.1 - 2.1e-12 47.1 0.0 7.6e-12 45.3 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS18114.1 - 3.2e-12 47.0 0.0 1.1e-10 42.1 0.0 3.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS18114.1 - 4e-12 46.6 0.0 4.7e-11 43.2 0.0 3.0 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 KOS18114.1 - 5.7e-12 45.5 0.0 6.6e-11 42.0 0.0 2.5 2 0 0 2 2 2 1 short chain dehydrogenase Epimerase PF01370.21 KOS18114.1 - 1.8e-10 40.7 0.0 2.1e-07 30.6 0.0 2.8 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family Methyltransf_23 PF13489.6 KOS18114.1 - 7.2e-09 35.7 0.0 1.8e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short_C2 PF13561.6 KOS18114.1 - 1.1e-06 28.3 0.0 3.3e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Thiolase_N PF00108.23 KOS18114.1 - 6.3e-05 22.5 0.0 0.00014 21.3 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ubie_methyltran PF01209.18 KOS18114.1 - 0.00022 20.6 0.0 0.00058 19.3 0.0 1.6 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family 3Beta_HSD PF01073.19 KOS18114.1 - 0.012 14.6 0.0 0.96 8.4 0.0 2.3 2 0 0 2 2 2 0 3-beta hydroxysteroid dehydrogenase/isomerase family NodS PF05401.11 KOS18114.1 - 0.017 14.7 0.0 0.036 13.7 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) GDP_Man_Dehyd PF16363.5 KOS18114.1 - 0.059 12.8 0.0 0.18 11.2 0.0 1.8 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Methyltransf_16 PF10294.9 KOS18114.1 - 0.095 12.4 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Lysine methyltransferase DREV PF05219.12 KOS18114.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase ACP_syn_III PF08545.10 KOS18114.1 - 0.14 12.0 2.4 0.15 11.9 0.2 2.3 2 0 0 2 2 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III NNMT_PNMT_TEMT PF01234.17 KOS18114.1 - 0.17 11.0 0.0 0.36 10.0 0.0 1.4 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family GMC_oxred_N PF00732.19 KOS18115.1 - 6.5e-54 183.3 0.0 9.4e-54 182.8 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS18115.1 - 2.9e-24 86.2 0.1 5.1e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 KOS18115.1 - 3.3e-05 23.1 0.1 6.5e-05 22.1 0.1 1.5 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KOS18115.1 - 0.001 19.3 7.0 0.0023 18.1 0.1 3.7 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOS18115.1 - 0.067 13.2 0.1 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOS18115.1 - 0.078 12.2 0.1 0.32 10.2 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS18115.1 - 0.13 11.5 0.1 0.25 10.6 0.1 1.4 1 0 0 1 1 1 0 Thi4 family MFS_1 PF07690.16 KOS18116.1 - 1.1e-38 133.1 41.6 1.1e-38 133.1 41.6 2.1 2 0 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS18116.1 - 5.2e-08 31.8 11.4 8.4e-08 31.1 11.4 1.5 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Pox_A14 PF05767.12 KOS18116.1 - 0.0082 16.3 0.3 1.1 9.4 0.2 2.7 2 0 0 2 2 2 2 Poxvirus virion envelope protein A14 DIM PF08194.12 KOS18117.1 - 0.6 10.4 0.1 0.6 10.4 0.1 2.2 3 1 0 3 3 3 0 DIM protein RRM_1 PF00076.22 KOS18118.1 - 4e-20 71.4 0.0 2.1e-14 53.1 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SpoIIP PF07454.11 KOS18118.1 - 5.5 6.4 14.4 1.6 8.2 9.4 2.0 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TCP PF03634.13 KOS18118.1 - 6.8 7.2 16.4 17 5.9 10.8 2.4 2 0 0 2 2 2 0 TCP family transcription factor CTU2 PF10288.9 KOS18118.1 - 9.9 6.4 11.9 1.5 9.1 5.2 2.3 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 LicD PF04991.13 KOS18119.1 - 4.1e-17 63.1 3.5 1.4e-10 41.7 2.2 2.9 1 1 1 2 2 2 2 LicD family SLATT_fungal PF18142.1 KOS18120.1 - 5.8e-33 113.4 0.6 7.7e-33 113.0 0.6 1.1 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain zf-C6H2 PF15801.5 KOS18121.1 - 0.024 14.9 15.4 0.082 13.2 1.4 3.0 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding CDC45 PF02724.14 KOS18121.1 - 0.39 9.0 1.2 0.51 8.6 1.2 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-MYND PF01753.18 KOS18121.1 - 2.1 8.5 22.6 0.54 10.4 4.4 3.4 3 0 0 3 3 3 0 MYND finger Striatin PF08232.12 KOS18122.1 - 1.9e-40 139.0 1.1 1.9e-40 139.0 1.1 2.4 2 0 0 2 2 2 1 Striatin family WD40 PF00400.32 KOS18122.1 - 5.6e-22 77.6 18.3 0.0002 22.1 0.3 7.5 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18122.1 - 2e-05 24.8 0.0 1.5 9.2 0.0 4.9 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Presenilin PF01080.17 KOS18122.1 - 1.2 7.8 6.1 1.9 7.1 6.1 1.3 1 0 0 1 1 1 0 Presenilin P5CR_dimer PF14748.6 KOS18123.1 - 3.5e-32 110.7 2.1 6.7e-32 109.8 2.1 1.5 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 KOS18123.1 - 4.1e-11 43.3 0.5 2.5e-09 37.6 0.0 2.6 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent zf-C2H2_jaz PF12171.8 KOS18124.1 - 2.8e-05 24.3 0.9 0.0067 16.7 0.0 3.6 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS18124.1 - 0.0034 17.7 0.9 0.46 11.0 0.3 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 KOS18124.1 - 0.015 15.7 0.7 0.015 15.7 0.7 5.0 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 KOS18124.1 - 0.043 13.6 0.6 0.13 12.1 0.6 1.7 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2_2 PF12756.7 KOS18124.1 - 5.2 7.5 11.0 2.2 8.7 0.8 3.4 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Actin PF00022.19 KOS18125.1 - 2.6e-41 141.6 0.0 6.9e-22 77.6 0.0 3.0 2 1 0 2 2 2 2 Actin Peptidase_M28 PF04389.17 KOS18126.1 - 9.6e-38 129.9 0.0 2.1e-37 128.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 KOS18126.1 - 0.00076 19.2 0.0 0.0014 18.3 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 KOS18126.1 - 0.11 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase LIDHydrolase PF10230.9 KOS18127.1 - 9.7e-53 179.4 0.0 1.1e-52 179.2 0.0 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Abhydrolase_6 PF12697.7 KOS18127.1 - 1.6e-05 25.6 0.3 2.2e-05 25.2 0.3 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS18127.1 - 0.0043 16.4 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KOS18127.1 - 0.031 14.1 0.0 0.051 13.4 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Acyltransferase PF01553.21 KOS18128.1 - 9.3e-27 93.3 0.0 1.4e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 KOS18128.1 - 1.4e-12 47.5 0.3 2.5e-12 46.7 0.3 1.4 1 0 0 1 1 1 1 Acyltransferase C-terminus NAD_kinase PF01513.21 KOS18129.1 - 4.5e-43 147.5 0.0 1.5e-42 145.8 0.0 1.6 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 KOS18129.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Gas_vesicle_C PF01304.17 KOS18129.1 - 0.97 9.5 3.1 1.3 9.1 0.6 2.0 2 0 0 2 2 2 0 Gas vesicles protein GVPc repeated domain GFO_IDH_MocA PF01408.22 KOS18130.1 - 1.4e-21 77.5 0.0 2.2e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 KOS18130.1 - 3.2e-09 36.8 0.0 6e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain NAD_binding_3 PF03447.16 KOS18130.1 - 0.095 13.4 0.0 0.2 12.3 0.0 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain PLA2_B PF01735.18 KOS18131.1 - 2.3e-174 580.4 0.3 2.7e-174 580.2 0.3 1.0 1 0 0 1 1 1 1 Lysophospholipase catalytic domain Amidase PF01425.21 KOS18132.1 - 7.5e-67 226.2 0.0 1.1e-66 225.6 0.0 1.2 1 0 0 1 1 1 1 Amidase CFEM PF05730.11 KOS18133.1 - 5.1e-11 42.5 11.2 8.2e-11 41.9 11.2 1.3 1 0 0 1 1 1 1 CFEM domain VID27 PF08553.10 KOS18135.1 - 8.4e-191 633.6 0.0 1.2e-190 633.1 0.0 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 KOS18135.1 - 4.4e-74 248.0 0.0 4.4e-74 248.0 0.0 4.0 4 0 0 4 4 4 1 VID27 N-terminal region VID27_PH PF17747.1 KOS18135.1 - 6.8e-36 122.9 0.0 1.3e-35 122.0 0.0 1.5 1 0 0 1 1 1 1 VID27 PH-like domain DUF2052 PF09747.9 KOS18135.1 - 0.84 9.7 25.5 0.46 10.6 4.9 2.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) CNDH2_C PF16858.5 KOS18135.1 - 1.7 8.4 11.9 2.7 7.8 3.2 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term BSP_II PF05432.11 KOS18135.1 - 3.1 7.4 26.8 0.48 10.1 5.8 2.7 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 KOS18135.1 - 3.9 6.8 24.5 4.3 6.7 9.9 2.4 2 0 0 2 2 2 0 SDA1 Tub_N PF16322.5 KOS18135.1 - 8.6 6.7 20.2 1 9.8 7.1 2.3 2 0 0 2 2 2 0 Tubby N-terminal ECH_1 PF00378.20 KOS18136.1 - 2.6e-37 128.5 0.2 1.4e-33 116.3 0.1 3.0 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS18136.1 - 2.3e-23 83.2 0.2 7.8e-20 71.6 0.1 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase DnaJ PF00226.31 KOS18137.1 - 1.4e-10 41.2 2.0 6.4e-10 39.0 2.0 2.0 1 1 0 1 1 1 1 DnaJ domain RPT PF13446.6 KOS18138.1 - 3.5e-13 49.2 0.0 6.8e-06 25.9 0.0 2.9 3 0 0 3 3 3 2 A repeated domain in UCH-protein VPS11_C PF12451.8 KOS18138.1 - 0.092 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal UCH PF00443.29 KOS18139.1 - 2.5e-26 92.7 0.0 3.3e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS18139.1 - 0.0033 17.1 0.0 0.005 16.5 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase T_hemolysin PF12261.8 KOS18139.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Thermostable hemolysin PLA1 PF02253.15 KOS18140.1 - 0.11 12.1 0.0 0.13 11.8 0.0 1.1 1 0 0 1 1 1 0 Phospholipase A1 Pkinase PF00069.25 KOS18141.1 - 2.5e-68 230.3 0.0 3.3e-68 229.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18141.1 - 5.6e-32 111.0 0.0 7.5e-32 110.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOS18141.1 - 0.00042 19.7 0.3 0.00071 19.0 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOS18141.1 - 0.0016 17.5 0.4 0.0031 16.5 0.4 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOS18141.1 - 0.0089 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS18141.1 - 0.027 14.4 0.2 0.066 13.1 0.2 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KOS18141.1 - 0.073 12.1 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Gag_p6 PF08705.11 KOS18141.1 - 0.096 12.9 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 Gag protein p6 Sec23_trunk PF04811.15 KOS18142.1 - 8.1e-71 238.4 0.0 1.3e-70 237.8 0.0 1.3 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 KOS18142.1 - 6.2e-24 83.8 0.0 2.8e-23 81.7 0.0 2.2 2 0 0 2 2 2 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 KOS18142.1 - 8.5e-18 64.9 0.0 1.8e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 KOS18142.1 - 1.9e-16 59.8 3.8 3.3e-16 59.0 3.8 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 KOS18142.1 - 4.2e-09 36.2 0.8 1.1e-08 34.8 0.0 2.3 2 0 0 2 2 2 1 Gelsolin repeat Vps36-NZF-N PF16988.5 KOS18142.1 - 0.014 14.7 0.1 0.033 13.6 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain HEM4 PF02602.15 KOS18143.1 - 2.6e-36 125.1 0.0 3.2e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD TLD PF07534.16 KOS18144.1 - 3.4e-25 88.9 0.0 4.5e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 TLD IBN_N PF03810.19 KOS18145.1 - 2.1e-07 30.8 2.4 2.1e-05 24.4 0.0 4.0 4 0 0 4 4 4 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KOS18145.1 - 6.5e-06 26.3 1.6 0.00036 20.6 0.1 3.2 3 0 0 3 3 3 1 Exportin 1-like protein IPPT PF01715.17 KOS18145.1 - 0.083 12.7 0.0 0.21 11.4 0.0 1.7 1 0 0 1 1 1 0 IPP transferase Fungal_trans_2 PF11951.8 KOS18148.1 - 1.4e-08 34.0 0.7 4.3e-08 32.4 0.0 1.9 2 1 0 2 2 2 1 Fungal specific transcription factor domain SHOCT PF09851.9 KOS18148.1 - 0.019 14.7 0.2 0.045 13.5 0.2 1.7 1 0 0 1 1 1 0 Short C-terminal domain PHC2_SAM_assoc PF16616.5 KOS18148.1 - 0.054 14.3 5.5 0.1 13.4 5.5 1.5 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 DUF773 PF05600.12 KOS18148.1 - 0.15 10.8 0.0 0.25 10.0 0.0 1.2 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 DUF1917 PF08939.10 KOS18149.1 - 2.7e-76 256.9 0.0 3.2e-76 256.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1917) Acetyltransf_1 PF00583.25 KOS18150.1 - 4.2e-17 62.4 0.0 5.4e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS18150.1 - 3.7e-10 39.8 0.0 5.1e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS18150.1 - 2.7e-09 36.9 0.0 4.2e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOS18150.1 - 3.1e-09 37.1 0.0 4.3e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOS18150.1 - 3.3e-07 31.1 0.0 3.8e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS18150.1 - 0.00031 20.8 0.0 0.00051 20.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 KOS18150.1 - 0.00058 19.6 0.0 0.00067 19.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOS18150.1 - 0.069 13.3 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase MRP-S25 PF13741.6 KOS18152.1 - 3.4e-65 219.8 5.0 1.3e-59 201.5 0.8 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 KOS18152.1 - 0.063 13.5 1.6 0.078 13.2 0.3 1.8 2 1 0 2 2 2 0 Mitochondrial ribosomal protein S23 FAD_binding_4 PF01565.23 KOS18153.1 - 2e-21 76.2 4.5 7e-21 74.4 4.9 1.8 2 0 0 2 2 2 1 FAD binding domain BBE PF08031.12 KOS18153.1 - 4e-11 42.8 0.4 8e-11 41.9 0.4 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 KOS18153.1 - 0.07 12.5 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding FAD_binding_4 PF01565.23 KOS18154.1 - 4.6e-21 75.0 1.1 1.1e-20 73.8 1.1 1.7 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS18154.1 - 3.1e-07 30.4 0.1 5.8e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Berberine and berberine like Abhydrolase_6 PF12697.7 KOS18156.1 - 7.5e-12 46.3 16.4 3.8e-10 40.7 16.4 2.2 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS18156.1 - 9.6e-07 28.7 0.0 2e-06 27.6 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS18156.1 - 0.00056 19.3 0.0 0.015 14.6 0.0 2.8 3 0 0 3 3 3 1 Serine aminopeptidase, S33 IRS PF02174.17 KOS18156.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 PTB domain (IRS-1 type) DUF3089 PF11288.8 KOS18156.1 - 0.053 13.1 0.1 0.11 12.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3089) Alg14 PF08660.11 KOS18157.1 - 1e-38 133.0 0.0 4.5e-27 95.1 0.0 2.1 1 1 1 2 2 2 2 Oligosaccharide biosynthesis protein Alg14 like Aldo_ket_red PF00248.21 KOS18158.1 - 1e-46 159.5 0.0 1.2e-46 159.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FAD_binding_3 PF01494.19 KOS18159.1 - 9.1e-20 71.2 1.0 5.1e-12 45.7 0.2 2.8 1 1 1 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOS18159.1 - 1.6e-06 28.3 0.2 4.6e-06 26.8 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS18159.1 - 3.8e-06 26.3 0.3 7.2e-06 25.4 0.3 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS18159.1 - 0.00023 21.7 0.2 0.0007 20.1 0.2 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS18159.1 - 0.0016 17.8 0.2 0.14 11.4 0.0 2.2 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS18159.1 - 0.0022 17.1 0.3 0.01 14.9 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.12 KOS18159.1 - 0.016 14.3 2.0 0.025 13.6 0.4 2.1 2 1 1 3 3 3 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 KOS18159.1 - 0.017 15.2 1.1 1.7 8.6 0.1 2.4 1 1 1 2 2 2 0 FAD-NAD(P)-binding Amino_oxidase PF01593.24 KOS18159.1 - 0.032 13.5 0.4 0.39 10.0 0.1 2.3 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Trp_halogenase PF04820.14 KOS18159.1 - 0.054 12.3 0.2 1.8 7.3 0.0 2.6 3 0 0 3 3 3 0 Tryptophan halogenase DAO PF01266.24 KOS18159.1 - 0.058 13.0 1.7 0.2 11.2 0.2 2.1 1 1 0 2 2 2 0 FAD dependent oxidoreductase Thi4 PF01946.17 KOS18159.1 - 0.095 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Thi4 family DIOX_N PF14226.6 KOS18160.1 - 2e-24 86.6 0.0 3.1e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOS18160.1 - 4.1e-17 62.5 0.0 7.3e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RhoGAP PF00620.27 KOS18161.1 - 1.2e-47 161.6 0.1 3.3e-47 160.1 0.0 1.8 2 0 0 2 2 2 1 RhoGAP domain FCH PF00611.23 KOS18161.1 - 7.9e-12 45.3 0.1 2.2e-11 43.9 0.1 1.8 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain DUF848 PF05852.11 KOS18161.1 - 0.23 11.6 4.6 0.059 13.5 1.1 1.8 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) FlgN PF05130.12 KOS18161.1 - 1.1 9.8 8.1 0.34 11.4 1.6 2.7 2 0 0 2 2 2 0 FlgN protein Med12 PF09497.10 KOS18162.1 - 1e-27 96.2 1.6 1.9e-27 95.3 0.3 2.3 2 0 0 2 2 2 1 Transcription mediator complex subunit Med12 Med12-LCEWAV PF12145.8 KOS18162.1 - 0.028 13.3 0.1 0.52 9.1 0.0 2.1 1 1 1 2 2 2 0 Eukaryotic Mediator 12 subunit domain Pyrid_oxidase_2 PF13883.6 KOS18163.1 - 7.4e-39 133.4 0.0 4.2e-38 131.0 0.0 2.0 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pkinase PF00069.25 KOS18164.1 - 6.8e-60 202.7 0.0 4.5e-59 200.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18164.1 - 1.4e-28 99.9 0.3 4.9e-20 71.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 KOS18164.1 - 0.00086 20.0 1.1 0.00086 20.0 1.1 2.4 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 KOS18164.1 - 0.0048 16.2 0.5 0.018 14.4 0.0 2.1 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 KOS18164.1 - 0.012 15.5 1.3 0.13 12.2 0.7 2.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS18164.1 - 0.015 14.3 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KOS18164.1 - 0.029 13.7 0.0 0.057 12.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF1752 PF08550.10 KOS18165.1 - 2e-10 40.3 0.2 4e-10 39.4 0.2 1.5 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) GCIP PF13324.6 KOS18165.1 - 0.36 10.4 2.9 0.6 9.7 2.9 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 KOS18165.1 - 0.85 8.9 15.5 1.4 8.1 15.5 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 KOS18165.1 - 6.8 6.3 19.8 4.7 6.9 12.1 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 KOS18165.1 - 9.1 6.7 12.1 33 5.0 12.1 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Wbp11 PF09429.10 KOS18166.1 - 1.8e-22 79.5 13.5 1.8e-22 79.5 13.5 2.4 2 0 0 2 2 2 1 WW domain binding protein 11 Serglycin PF04360.12 KOS18166.1 - 0.07 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Serglycin MFS_1 PF07690.16 KOS18167.1 - 1.9e-36 125.7 72.3 1.7e-34 119.3 46.1 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS18167.1 - 6.7e-06 25.2 36.9 0.00022 20.2 14.7 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter DUF5090 PF17009.5 KOS18167.1 - 3.3 7.6 9.1 0.15 12.0 1.7 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5090) DFP PF04127.15 KOS18168.1 - 4.5e-11 42.9 0.0 6.6e-06 26.1 0.0 3.1 3 0 0 3 3 3 3 DNA / pantothenate metabolism flavoprotein Acatn PF13000.7 KOS18169.1 - 2.4e-156 521.5 11.6 2.5e-81 273.9 7.4 3.2 1 1 2 3 3 3 3 Acetyl-coenzyme A transporter 1 Serglycin PF04360.12 KOS18169.1 - 0.5 10.3 17.8 38 4.2 17.8 2.3 1 1 0 1 1 1 0 Serglycin CENP-O PF09496.10 KOS18170.1 - 7.3e-56 189.5 0.0 1.5e-55 188.5 0.0 1.5 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component Macoilin PF09726.9 KOS18170.1 - 0.00019 20.2 2.6 0.00019 20.1 2.6 1.2 1 0 0 1 1 1 1 Macoilin family Apt1 PF10351.9 KOS18170.1 - 0.072 11.9 12.5 0.11 11.4 12.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Striatin PF08232.12 KOS18170.1 - 0.25 11.9 2.8 0.42 11.2 2.8 1.3 1 0 0 1 1 1 0 Striatin family RP-C_C PF11800.8 KOS18170.1 - 0.26 11.4 4.6 0.49 10.5 4.6 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region ATF7IP_BD PF16788.5 KOS18170.1 - 2.8 8.0 11.5 4.1 7.4 11.5 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain Mito_fiss_reg PF05308.11 KOS18170.1 - 8.6 6.4 15.1 1.1 9.3 10.6 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator Tma16 PF11176.8 KOS18171.1 - 8.8e-48 161.9 0.0 1.1e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 FliD_C PF07195.12 KOS18171.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus CHASE7 PF17151.4 KOS18171.1 - 0.13 11.9 0.3 0.17 11.4 0.3 1.2 1 0 0 1 1 1 0 Periplasmic sensor domain HTH_32 PF13565.6 KOS18171.1 - 0.14 12.8 0.8 0.58 10.8 0.0 2.1 2 1 0 2 2 2 0 Homeodomain-like domain RHH_1 PF01402.21 KOS18171.1 - 0.24 11.4 1.9 1.8 8.7 0.1 2.6 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family XPG_N PF00752.17 KOS18172.1 - 8.3e-25 87.2 0.0 1.5e-24 86.4 0.0 1.4 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOS18172.1 - 1.6e-22 79.7 0.0 3.3e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 KOS18172.1 - 0.0015 18.1 0.0 0.0023 17.4 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 KOS18172.1 - 0.0044 17.0 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat 5_3_exonuc PF01367.20 KOS18172.1 - 0.014 16.0 0.0 0.043 14.4 0.0 1.8 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold TPR_14 PF13428.6 KOS18172.1 - 0.022 15.5 0.0 0.092 13.6 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOS18172.1 - 0.073 12.9 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat HHH_5 PF14520.6 KOS18172.1 - 0.1 13.2 0.0 1 10.0 0.0 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix domain Oxysterol_BP PF01237.18 KOS18173.1 - 4.7e-51 173.8 0.0 3.5e-49 167.6 0.0 2.2 1 1 0 1 1 1 1 Oxysterol-binding protein MAM33 PF02330.16 KOS18174.1 - 3.2e-75 252.7 1.9 4e-75 252.4 1.9 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein KCT2 PF17818.1 KOS18174.1 - 3.9 7.5 8.1 0.61 10.2 0.7 2.2 1 1 1 2 2 2 0 Keratinocyte-associated gene product PUF PF00806.19 KOS18175.1 - 3.1e-08 32.9 0.0 0.47 10.3 0.0 5.5 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat GCIP PF13324.6 KOS18175.1 - 0.061 12.9 0.1 0.061 12.9 0.1 2.1 2 1 0 2 2 2 0 Grap2 and cyclin-D-interacting Mito_fiss_reg PF05308.11 KOS18176.1 - 9 6.3 20.6 0.08 13.0 4.1 3.0 2 1 0 2 2 2 0 Mitochondrial fission regulator AMMECR1 PF01871.17 KOS18177.1 - 3.1e-43 147.3 0.0 3.8e-43 147.0 0.0 1.2 1 0 0 1 1 1 1 AMMECR1 Senescence_reg PF04520.13 KOS18177.1 - 0.047 14.5 1.0 0.064 14.1 1.0 1.2 1 0 0 1 1 1 0 Senescence regulator ORC6 PF05460.13 KOS18177.1 - 0.2 10.9 5.2 0.24 10.6 5.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Cwf_Cwc_15 PF04889.12 KOS18177.1 - 0.25 11.1 1.8 0.34 10.6 1.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ras PF00071.22 KOS18178.1 - 9.2e-39 132.6 0.0 1.2e-24 86.7 0.0 2.0 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KOS18178.1 - 4.3e-11 43.1 0.0 7.6e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS18178.1 - 0.0013 18.2 0.0 0.014 14.9 0.0 2.0 1 1 1 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS18178.1 - 0.0016 18.5 0.0 0.0023 18.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase T_hemolysin PF12261.8 KOS18178.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Thermostable hemolysin PRK PF00485.18 KOS18178.1 - 0.12 12.0 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family FHA PF00498.26 KOS18179.1 - 4.7e-15 55.7 0.0 8.2e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOS18179.1 - 0.0027 18.0 0.0 0.084 13.2 0.0 2.2 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain TEX13 PF15186.6 KOS18180.1 - 0.23 11.1 0.1 0.23 11.1 0.1 2.1 2 0 0 2 2 2 0 Testis-expressed sequence 13 protein family DUF2070 PF09843.9 KOS18180.1 - 0.31 9.3 4.6 0.42 8.8 4.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) COX6C PF02937.15 KOS18180.1 - 4.8 7.4 6.0 5 7.3 0.3 3.1 3 1 0 3 3 3 0 Cytochrome c oxidase subunit VIc Thioesterase PF00975.20 KOS18181.1 - 5.1e-07 30.1 0.1 4.5e-06 26.9 0.1 2.1 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_6 PF12697.7 KOS18181.1 - 0.23 12.0 14.2 1.2 9.7 14.2 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Couple_hipA PF13657.6 KOS18183.1 - 0.036 14.7 0.1 1.4 9.6 0.1 2.5 1 1 1 2 2 2 0 HipA N-terminal domain adh_short_C2 PF13561.6 KOS18184.1 - 1.2e-63 214.9 1.0 1.3e-63 214.7 1.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS18184.1 - 1.9e-40 138.4 0.6 2.4e-40 138.1 0.6 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS18184.1 - 3.9e-15 56.2 0.7 5.5e-15 55.7 0.7 1.2 1 0 0 1 1 1 1 KR domain OPT PF03169.15 KOS18185.1 - 9.3e-83 278.9 42.5 1.1e-82 278.7 42.5 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF3093 PF11292.8 KOS18185.1 - 0.38 11.0 6.6 0.47 10.7 0.6 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) Kinesin PF00225.23 KOS18186.1 - 5.6e-117 390.4 0.7 7.8e-117 389.9 0.7 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOS18186.1 - 1.9e-28 99.3 0.0 4.7e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding AAA_33 PF13671.6 KOS18186.1 - 0.0004 20.6 1.4 0.011 16.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain ArgoL2 PF16488.5 KOS18186.1 - 0.19 12.1 0.3 0.45 10.9 0.3 1.7 1 0 0 1 1 1 0 Argonaute linker 2 domain Herpes_UL14 PF03580.14 KOS18186.1 - 0.38 11.0 7.2 0.069 13.4 1.2 2.4 2 1 1 3 3 3 0 Herpesvirus UL14-like protein AAA_16 PF13191.6 KOS18186.1 - 1.7 9.0 4.1 4.2 7.7 0.0 2.9 2 1 1 3 3 3 0 AAA ATPase domain zf-C2H2_4 PF13894.6 KOS18187.1 - 2.1e-07 31.2 2.0 0.012 16.4 0.1 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS18187.1 - 5.8e-06 26.5 2.8 0.032 14.7 0.1 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type K_channel_TID PF07941.11 KOS18187.1 - 0.054 13.9 9.2 0.21 12.1 0.6 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain LicD PF04991.13 KOS18187.1 - 0.12 12.5 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 LicD family zf-Di19 PF05605.12 KOS18187.1 - 0.27 11.6 1.2 5.4 7.4 0.8 2.2 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Glyco_hydro_79C PF16862.5 KOS18188.1 - 1.2e-16 61.5 2.5 1.8e-16 60.9 1.4 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 79 C-terminal beta domain Fungal_trans PF04082.18 KOS18189.1 - 6.9e-10 38.4 0.0 1.3e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Tim17 PF02466.19 KOS18190.1 - 0.00024 21.5 3.9 0.00027 21.3 2.6 1.6 1 1 1 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family CGI-121 PF08617.10 KOS18192.1 - 3.6e-48 163.7 0.1 4.1e-48 163.6 0.1 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 CAMP_factor PF07373.11 KOS18192.1 - 0.082 12.5 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 CAMP factor (Cfa) Pro_dh PF01619.18 KOS18193.1 - 2.8e-71 240.5 0.0 3.2e-71 240.3 0.0 1.0 1 0 0 1 1 1 1 Proline dehydrogenase WH1 PF00568.23 KOS18196.1 - 2.1e-28 98.5 0.9 3.2e-28 97.9 0.9 1.3 1 0 0 1 1 1 1 WH1 domain DCP1 PF06058.13 KOS18196.1 - 0.22 11.5 0.4 0.36 10.8 0.4 1.3 1 0 0 1 1 1 0 Dcp1-like decapping family eIF-1a PF01176.19 KOS18197.1 - 3.3e-20 71.6 0.0 4.6e-20 71.2 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 fn3_2 PF16893.5 KOS18198.1 - 3e-36 123.5 0.0 5.2e-36 122.7 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 KOS18198.1 - 5.9e-23 80.6 0.7 1.1e-22 79.7 0.7 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus PTCB-BRCT PF12738.7 KOS18198.1 - 1.8e-11 43.8 0.0 3.2e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 twin BRCT domain BRCT PF00533.26 KOS18198.1 - 4.9e-10 39.6 0.0 8.3e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain DUF3006 PF11213.8 KOS18198.1 - 0.00019 21.6 0.0 0.00019 21.6 0.0 3.2 4 0 0 4 4 4 1 Protein of unknown function (DUF3006) BRCT_2 PF16589.5 KOS18198.1 - 0.00054 20.3 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain fn3 PF00041.21 KOS18198.1 - 0.018 15.3 0.0 0.076 13.4 0.0 2.0 1 1 0 1 1 1 0 Fibronectin type III domain PPP4R2 PF09184.11 KOS18198.1 - 0.13 11.8 16.8 0.18 11.3 16.8 1.3 1 0 0 1 1 1 0 PPP4R2 TFIIA PF03153.13 KOS18198.1 - 0.2 11.6 23.8 0.27 11.2 23.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit adh_short PF00106.25 KOS18199.1 - 1.4e-10 40.9 0.0 0.00023 20.7 0.0 2.4 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS18199.1 - 3.5e-09 36.6 0.0 1.7e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS18199.1 - 0.00021 21.3 0.0 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 KR domain CDP-OH_P_transf PF01066.21 KOS18201.1 - 1.3e-14 54.7 0.5 2.6e-14 53.7 0.5 1.6 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase DUF2062 PF09835.9 KOS18201.1 - 1 9.2 6.8 0.93 9.3 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2062) F-box-like PF12937.7 KOS18203.1 - 2.2e-09 37.1 0.2 4.4e-07 29.7 0.0 3.0 2 1 1 3 3 3 2 F-box-like F-box PF00646.33 KOS18203.1 - 6.2e-06 26.0 0.5 3.5e-05 23.6 0.0 2.3 2 0 0 2 2 2 1 F-box domain F-box_4 PF15966.5 KOS18203.1 - 0.19 11.6 0.5 0.56 10.1 0.0 2.1 2 1 0 2 2 2 0 F-box Ribosomal_L24e PF01246.20 KOS18204.1 - 2.9e-29 101.1 0.1 2.9e-29 101.1 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L24e Redoxin PF08534.10 KOS18205.1 - 1.2e-35 122.3 0.2 1.4e-35 122.2 0.2 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOS18205.1 - 1.4e-09 38.0 0.1 1.8e-09 37.6 0.1 1.1 1 0 0 1 1 1 1 AhpC/TSA family LpxI_N PF17930.1 KOS18205.1 - 0.098 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 LpxI N-terminal domain FAD-oxidase_C PF02913.19 KOS18206.1 - 1.9e-57 194.8 0.1 3.3e-57 194.0 0.1 1.4 1 1 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOS18206.1 - 1.2e-35 122.3 0.1 2.5e-35 121.2 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain SepSecS PF05889.13 KOS18206.1 - 0.022 13.4 0.1 0.047 12.4 0.0 1.5 2 0 0 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS RdRP PF05183.12 KOS18207.1 - 3.2e-27 95.4 0.0 4e-27 95.1 0.0 1.1 1 0 0 1 1 1 1 RNA dependent RNA polymerase Pex14_N PF04695.13 KOS18208.1 - 0.037 14.7 1.0 0.037 14.7 1.0 1.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Fumble PF03630.14 KOS18209.1 - 2.7e-144 480.4 0.0 3.5e-144 480.0 0.0 1.1 1 0 0 1 1 1 1 Fumble SPX PF03105.19 KOS18209.1 - 0.031 14.2 3.5 0.043 13.7 3.5 1.2 1 0 0 1 1 1 0 SPX domain DUF3669 PF12417.8 KOS18210.1 - 1.7e-08 34.5 0.0 3.7e-08 33.5 0.0 1.5 1 0 0 1 1 1 1 Zinc finger protein RGS PF00615.19 KOS18211.1 - 2.4e-07 31.1 0.0 0.0012 19.1 0.0 2.2 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF4335 PF14233.6 KOS18211.1 - 0.12 12.3 0.2 0.21 11.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4335) Anoctamin PF04547.12 KOS18212.1 - 1.4e-106 357.1 4.6 1.7e-106 356.8 4.6 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Metallophos PF00149.28 KOS18213.1 - 7.9e-13 49.4 2.6 1.7e-12 48.3 2.6 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOS18213.1 - 0.0045 17.2 3.5 0.019 15.2 3.5 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Aminotran_1_2 PF00155.21 KOS18214.1 - 5.2e-58 197.0 0.0 6e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Glyco_hydro_76 PF03663.14 KOS18217.1 - 8.9e-136 453.2 6.9 1e-135 453.0 6.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOS18217.1 - 0.0013 17.8 9.9 0.013 14.6 0.7 3.2 3 1 1 4 4 4 2 Glycosyl Hydrolase Family 88 Glyco_hydro_127 PF07944.12 KOS18217.1 - 0.14 10.6 1.0 9.9 4.5 0.1 2.8 2 1 0 2 2 2 0 Beta-L-arabinofuranosidase, GH127 FA_hydroxylase PF04116.13 KOS18218.1 - 1.3e-25 90.3 16.1 1.3e-25 90.3 16.1 2.0 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily NCA2 PF08637.10 KOS18219.1 - 3.1e-108 361.3 0.1 5.7e-108 360.5 0.0 1.5 2 0 0 2 2 2 1 ATP synthase regulation protein NCA2 TMEM171 PF15471.6 KOS18219.1 - 0.13 11.2 0.1 0.21 10.5 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 APH PF01636.23 KOS18220.1 - 0.02 14.8 0.9 0.11 12.4 0.9 1.9 1 1 0 1 1 1 0 Phosphotransferase enzyme family MFS_1 PF07690.16 KOS18221.1 - 5.2e-35 121.0 34.9 5.2e-35 121.0 34.9 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily SKG6 PF08693.10 KOS18222.1 - 0.024 14.0 0.1 0.024 14.0 0.1 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain PIP5K PF01504.18 KOS18223.1 - 2.8e-103 344.9 0.4 5e-103 344.1 0.4 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase COX6B PF02297.17 KOS18224.1 - 2e-20 72.8 1.6 3e-20 72.2 1.6 1.2 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb SYS1 PF09801.9 KOS18225.1 - 4.2e-48 163.2 3.7 4.9e-48 162.9 3.7 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network Lactamase_B_6 PF16661.5 KOS18226.1 - 1.9e-65 219.9 0.0 2.9e-65 219.3 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 KOS18226.1 - 5.5e-56 189.4 1.2 5.5e-56 189.4 1.2 2.4 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal Beta-Casp PF10996.8 KOS18226.1 - 1.3e-17 64.1 0.0 6e-17 61.9 0.0 2.2 1 0 0 1 1 1 1 Beta-Casp domain RMMBL PF07521.12 KOS18226.1 - 5.6e-15 55.0 0.0 1.5e-14 53.7 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 KOS18226.1 - 0.035 13.6 0.0 0.11 12.0 0.0 2.0 1 1 0 1 1 1 0 Beta-lactamase superfamily domain Roughex PF06020.11 KOS18226.1 - 0.11 11.6 4.9 0.23 10.5 4.9 1.4 1 0 0 1 1 1 0 Drosophila roughex protein NAD_binding_6 PF08030.12 KOS18227.1 - 4.4e-32 111.4 0.0 9.3e-32 110.3 0.0 1.6 2 0 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS18227.1 - 6.2e-19 68.1 0.0 2.1e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 FAD-binding domain Ferric_reduct PF01794.19 KOS18227.1 - 3.5e-17 62.7 11.2 3.5e-17 62.7 11.2 2.3 1 1 1 2 2 2 1 Ferric reductase like transmembrane component UQ_con PF00179.26 KOS18228.1 - 1e-43 148.3 0.0 1.2e-43 148.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS18228.1 - 0.0021 17.8 0.0 0.0024 17.6 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOS18228.1 - 0.0042 17.4 0.0 0.0058 16.9 0.0 1.2 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOS18228.1 - 0.012 15.5 0.0 0.019 14.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain AlaDh_PNT_N PF05222.15 KOS18229.1 - 1.3e-19 70.8 0.0 2e-19 70.3 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 KOS18229.1 - 0.00025 20.4 0.0 0.00056 19.3 0.0 1.5 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOS18230.1 - 2.8e-24 85.9 0.1 5.7e-24 85.0 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 KOS18230.1 - 5.7e-24 85.0 0.8 8.4e-24 84.5 0.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KOS18230.1 - 1.7e-15 57.0 0.0 2.9e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOS18230.1 - 3.2e-06 27.5 0.5 5.6e-06 26.7 0.5 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Methyltransf_25 PF13649.6 KOS18231.1 - 3.3e-15 56.6 0.0 6.3e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS18231.1 - 5.7e-14 52.7 0.0 1.8e-13 51.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS18231.1 - 1.4e-11 44.9 0.0 2.8e-11 43.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS18231.1 - 7.3e-11 42.2 0.0 1.2e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS18231.1 - 1.4e-06 28.1 0.0 2.4e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS18231.1 - 2.4e-06 27.1 0.0 3.4e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_8 PF05148.15 KOS18231.1 - 0.0004 20.3 0.0 0.0067 16.3 0.0 2.3 1 1 0 1 1 1 1 Hypothetical methyltransferase NNMT_PNMT_TEMT PF01234.17 KOS18231.1 - 0.00072 18.8 0.0 0.41 9.8 0.0 2.2 1 1 1 2 2 2 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 KOS18231.1 - 0.0025 18.8 0.0 0.0066 17.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOS18231.1 - 0.012 15.2 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_32 PF13679.6 KOS18231.1 - 0.21 11.5 0.0 0.47 10.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Polyketide_cyc PF03364.20 KOS18232.1 - 7.2e-23 81.2 0.0 1.1e-22 80.7 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DPM2 PF07297.12 KOS18233.1 - 5.4e-34 116.3 1.7 6.2e-34 116.1 1.7 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF4229 PF14012.6 KOS18233.1 - 0.0014 18.7 0.9 0.0014 18.7 0.9 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4229) PIG-P PF08510.12 KOS18233.1 - 0.0014 18.6 0.7 0.0016 18.4 0.7 1.1 1 0 0 1 1 1 1 PIG-P MlaE PF02405.16 KOS18233.1 - 0.0015 18.3 0.1 0.0015 18.3 0.1 1.5 2 0 0 2 2 2 1 Permease MlaE LapA_dom PF06305.11 KOS18233.1 - 0.0052 16.6 0.8 0.0052 16.6 0.8 1.9 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain Phage_holin_3_6 PF07332.11 KOS18233.1 - 0.0096 15.9 3.2 0.011 15.7 3.2 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF5470 PF17564.2 KOS18234.1 - 0.12 12.6 3.0 0.16 12.2 3.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5470) SR-25 PF10500.9 KOS18234.1 - 0.38 10.3 9.1 0.43 10.2 9.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 KOS18234.1 - 6.7 7.0 14.6 9 6.6 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Abhydrolase_3 PF07859.13 KOS18235.1 - 2.4e-45 155.0 0.4 1.1e-30 107.1 0.4 2.2 1 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS18235.1 - 9.5e-05 23.1 10.9 9.5e-05 23.1 10.9 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family COesterase PF00135.28 KOS18235.1 - 0.0052 15.7 0.0 0.012 14.5 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Ribosomal_60s PF00428.19 KOS18235.1 - 0.47 11.1 6.9 0.74 10.4 1.0 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein DNA_pol3_theta PF06440.11 KOS18238.1 - 0.076 12.7 0.0 0.1 12.2 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase III, theta subunit Epimerase PF01370.21 KOS18239.1 - 5.2e-15 55.6 0.0 1.4e-14 54.2 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS18239.1 - 1.1e-10 41.4 0.0 1.6e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KOS18239.1 - 2.7e-09 37.2 0.0 1e-08 35.3 0.0 1.8 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KOS18239.1 - 8.3e-08 31.7 0.0 0.0018 17.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein 3Beta_HSD PF01073.19 KOS18239.1 - 1.3e-07 31.0 0.0 1.9e-07 30.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 KOS18239.1 - 0.00041 20.0 0.0 0.0018 17.9 0.0 1.9 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 KOS18239.1 - 0.00043 19.8 0.1 0.00066 19.2 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 KOS18239.1 - 0.0053 15.9 0.1 0.0074 15.5 0.1 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOS18239.1 - 0.03 13.4 0.1 0.053 12.6 0.1 1.4 1 0 0 1 1 1 0 RmlD substrate binding domain DUF2742 PF10888.8 KOS18239.1 - 0.11 12.7 0.2 12 6.3 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2742) ADH_N_2 PF16884.5 KOS18240.1 - 1.2e-29 102.3 0.0 2.5e-29 101.3 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 KOS18240.1 - 8.4e-21 74.3 0.1 1.6e-20 73.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS18240.1 - 9.3e-08 33.2 0.0 1.6e-07 32.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Fringe PF02434.16 KOS18241.1 - 1e-07 31.7 0.0 1.5e-07 31.1 0.0 1.2 1 0 0 1 1 1 1 Fringe-like PAN_4 PF14295.6 KOS18241.1 - 0.016 15.1 0.6 0.044 13.7 0.6 1.7 1 0 0 1 1 1 0 PAN domain PAN_1 PF00024.26 KOS18241.1 - 0.034 14.1 0.2 0.069 13.1 0.2 1.4 1 0 0 1 1 1 0 PAN domain RTA1 PF04479.13 KOS18243.1 - 2.8e-59 200.2 10.0 4.3e-59 199.6 10.0 1.3 1 0 0 1 1 1 1 RTA1 like protein HKR_ArcB_TM PF18415.1 KOS18243.1 - 0.0096 16.7 0.4 0.0096 16.7 0.4 2.2 3 0 0 3 3 3 1 Histidine kinase receptor ArcB trans-membrane domain Aldedh PF00171.22 KOS18244.1 - 6.2e-123 410.7 0.2 1.8e-122 409.2 0.2 1.6 1 1 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 KOS18244.1 - 0.0026 16.9 0.0 0.0044 16.1 0.0 1.4 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Rad60-SLD_2 PF13881.6 KOS18246.1 - 3e-12 46.6 0.0 3.8e-12 46.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOS18246.1 - 1.3e-05 24.8 0.0 2.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 KOS18246.1 - 0.00022 21.7 0.0 0.00029 21.4 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Binary_toxB PF03495.14 KOS18246.1 - 0.047 13.9 0.1 0.073 13.3 0.1 1.4 1 1 0 1 1 1 0 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain Adaptin_N PF01602.20 KOS18247.1 - 2.4e-122 409.2 6.9 2.4e-122 409.2 6.9 1.3 2 0 0 2 2 2 1 Adaptin N terminal region Cnd1 PF12717.7 KOS18247.1 - 5.9e-53 179.2 8.2 3.5e-52 176.7 0.2 3.6 3 1 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS18247.1 - 3e-15 56.4 3.2 1.8e-07 31.4 0.1 4.7 4 1 0 4 4 4 3 HEAT repeats HEAT PF02985.22 KOS18247.1 - 1.8e-08 33.9 4.5 0.37 11.2 0.0 5.7 6 0 0 6 6 6 3 HEAT repeat HEAT_EZ PF13513.6 KOS18247.1 - 0.0017 18.8 3.4 6.3 7.4 0.1 5.7 6 1 1 7 7 7 1 HEAT-like repeat CLASP_N PF12348.8 KOS18247.1 - 0.011 15.3 1.1 2 7.9 0.0 3.1 2 1 0 3 3 3 0 CLASP N terminal RTP1_C1 PF10363.9 KOS18247.1 - 0.018 15.2 1.9 0.81 9.9 0.1 3.4 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 KOS18247.1 - 0.019 15.0 1.8 1.5 9.0 0.0 4.3 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 KOS18247.1 - 0.02 14.9 0.2 9.6 6.3 0.0 4.1 4 1 1 5 5 5 0 Spinocerebellar ataxia type 10 protein domain Med15 PF09606.10 KOS18247.1 - 2 7.0 7.5 2.8 6.5 7.5 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1077 PF06417.12 KOS18248.1 - 2e-49 166.5 4.0 2.4e-49 166.3 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) Syntaxin-18_N PF10496.9 KOS18249.1 - 8.7e-09 35.5 0.3 9.2e-07 29.0 0.0 2.9 2 1 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 KOS18249.1 - 0.011 15.7 0.0 0.049 13.6 0.0 2.1 2 0 0 2 2 2 0 SNARE domain CENP-H PF05837.12 KOS18249.1 - 0.13 12.7 10.3 0.13 12.6 0.8 2.8 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Aminotran_1_2 PF00155.21 KOS18250.1 - 1.3e-83 281.1 0.0 1.5e-83 281.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RHH_1 PF01402.21 KOS18251.1 - 0.013 15.5 0.2 0.022 14.7 0.2 1.4 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family NMD3 PF04981.13 KOS18252.1 - 7.3e-79 264.7 1.9 1.1e-78 264.0 1.9 1.3 1 0 0 1 1 1 1 NMD3 family CvfB_WH PF17783.1 KOS18252.1 - 0.18 11.7 0.5 0.38 10.6 0.5 1.6 1 0 0 1 1 1 0 CvfB-like winged helix domain DZR PF12773.7 KOS18252.1 - 0.37 10.9 9.8 2.8 8.1 0.1 2.9 2 1 0 2 2 2 0 Double zinc ribbon DUF35_N PF12172.8 KOS18252.1 - 0.38 10.7 0.1 0.38 10.7 0.1 2.9 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.19 KOS18252.1 - 2.6 8.1 7.7 11 6.1 2.4 2.7 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RRM_1 PF00076.22 KOS18253.1 - 0.00017 21.3 0.0 0.018 14.8 0.0 2.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cobW PF02492.19 KOS18254.1 - 1.7e-47 161.3 0.1 2.2e-47 160.9 0.1 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 KOS18254.1 - 2.4e-05 24.3 0.0 0.24 11.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOS18254.1 - 0.0048 16.5 0.0 2.1 7.9 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS18254.1 - 0.0069 16.5 0.0 0.015 15.4 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase CobW_C PF07683.14 KOS18254.1 - 0.0077 16.1 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain AAA_23 PF13476.6 KOS18254.1 - 0.0093 16.5 0.1 0.021 15.3 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOS18254.1 - 0.011 16.1 0.0 0.042 14.2 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 KOS18254.1 - 0.021 13.8 1.0 2.7 6.9 0.1 2.7 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 KOS18254.1 - 0.037 13.8 0.4 0.27 11.0 0.4 2.0 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 KOS18254.1 - 0.038 13.7 0.5 0.43 10.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOS18254.1 - 0.059 13.1 0.2 0.19 11.5 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain T2SSE PF00437.20 KOS18254.1 - 0.068 12.2 0.4 0.22 10.6 0.1 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein TsaE PF02367.17 KOS18254.1 - 0.08 12.9 0.1 0.23 11.5 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 KOS18254.1 - 0.098 12.9 0.3 0.4 11.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 KOS18254.1 - 0.11 11.7 0.1 9.8 5.4 0.0 2.3 2 0 0 2 2 2 0 Septin ABC_tran PF00005.27 KOS18254.1 - 0.17 12.4 0.1 0.76 10.3 0.0 2.0 2 0 0 2 2 2 0 ABC transporter NOT2_3_5 PF04153.18 KOS18255.1 - 2.3e-30 105.4 0.8 3.5e-30 104.8 0.8 1.3 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family CUE PF02845.16 KOS18256.1 - 1.3e-09 37.6 0.0 1.9e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 CUE domain Cue1_U7BR PF18499.1 KOS18256.1 - 0.11 12.6 1.2 0.21 11.6 1.2 1.5 1 0 0 1 1 1 0 Ubc7p-binding region of Cue1 G2BR PF18442.1 KOS18256.1 - 0.35 10.6 5.7 0.87 9.3 5.7 1.6 1 0 0 1 1 1 0 E3 gp78 Ube2g2-binding region (G2BR) DnaJ PF00226.31 KOS18257.1 - 2.3e-21 75.7 1.9 6.1e-21 74.3 1.9 1.8 1 0 0 1 1 1 1 DnaJ domain SMC_N PF02463.19 KOS18258.1 - 3.7e-71 239.1 0.0 5.7e-70 235.2 0.0 2.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 KOS18258.1 - 5.8e-21 75.0 1.8 1.4e-20 73.7 0.5 2.5 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 KOS18258.1 - 1.7e-07 31.4 8.7 0.0016 18.3 0.0 3.3 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system MscS_porin PF12795.7 KOS18258.1 - 0.00085 18.9 19.0 0.00085 18.9 19.0 6.9 4 2 2 6 6 6 3 Mechanosensitive ion channel porin domain AAA_29 PF13555.6 KOS18258.1 - 0.0011 18.7 0.1 0.0025 17.5 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Lebercilin PF15619.6 KOS18258.1 - 0.0016 18.1 5.7 0.0016 18.1 5.7 7.1 3 2 3 7 7 7 2 Ciliary protein causing Leber congenital amaurosis disease DUF4846 PF16138.5 KOS18258.1 - 0.024 14.2 1.1 0.44 10.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (4846) HSBP1 PF06825.12 KOS18258.1 - 0.027 14.3 11.4 0.25 11.2 0.4 3.8 3 0 0 3 3 3 0 Heat shock factor binding protein 1 ABC_tran PF00005.27 KOS18258.1 - 0.056 14.0 0.0 0.056 14.0 0.0 5.5 3 2 0 4 4 4 0 ABC transporter MOSC PF03473.17 KOS18259.1 - 1e-22 80.5 0.0 1.5e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 MOSC domain MOSC_N PF03476.16 KOS18259.1 - 2.7e-06 27.2 0.0 5.3e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 MOSC N-terminal beta barrel domain DUF3990 PF13151.6 KOS18260.1 - 0.066 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3990) Herpes_UL42 PF02282.16 KOS18260.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase processivity factor (UL42) Mob1_phocein PF03637.17 KOS18261.1 - 3.3e-22 79.3 0.2 5.4e-22 78.6 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family CxC6 PF18721.1 KOS18261.1 - 0.11 12.8 4.2 0.27 11.5 4.2 1.6 1 0 0 1 1 1 0 CxC6 like cysteine cluster associated with KDZ transposases INCENP_ARK-bind PF03941.15 KOS18262.1 - 1.1e-22 79.7 2.9 2.5e-22 78.6 2.9 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region NT5C PF06941.12 KOS18263.1 - 0.055 13.3 0.0 0.055 13.3 0.0 1.0 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) IBN_N PF03810.19 KOS18264.1 - 2.2e-09 37.1 0.0 9.6e-08 31.8 0.0 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 KOS18264.1 - 0.0021 18.1 0.0 0.015 15.3 0.0 2.5 2 0 0 2 2 2 1 Exportin 1-like protein Cse1 PF08506.10 KOS18264.1 - 0.038 12.8 0.1 0.1 11.4 0.0 1.7 2 0 0 2 2 2 0 Cse1 DUF3844 PF12955.7 KOS18265.1 - 2.3e-32 111.3 3.2 2.3e-32 111.3 3.2 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3844) EGF_2 PF07974.13 KOS18265.1 - 9.4 6.7 9.9 97 3.5 9.9 2.6 1 1 0 1 1 1 0 EGF-like domain adh_short_C2 PF13561.6 KOS18266.1 - 1.1e-44 152.7 0.4 1.4e-44 152.4 0.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS18266.1 - 7.7e-40 136.4 0.0 1e-39 136.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS18266.1 - 3.9e-07 30.2 0.1 5.1e-07 29.8 0.1 1.1 1 0 0 1 1 1 1 KR domain PapA_C PF16911.5 KOS18266.1 - 0.043 13.9 0.0 0.078 13.1 0.0 1.5 1 0 0 1 1 1 0 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus RabGAP-TBC PF00566.18 KOS18267.1 - 9.4e-46 156.2 0.0 2e-45 155.1 0.0 1.6 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Spc7 PF08317.11 KOS18267.1 - 0.0021 17.0 4.7 0.0021 17.0 4.7 2.6 3 0 0 3 3 3 1 Spc7 kinetochore protein BicD PF09730.9 KOS18267.1 - 0.0022 16.5 12.2 0.0039 15.7 12.2 1.3 1 0 0 1 1 1 1 Microtubule-associated protein Bicaudal-D SYCE1 PF15233.6 KOS18267.1 - 0.029 14.4 10.5 1.5 8.9 5.6 2.7 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 Sec6 PF06046.13 KOS18267.1 - 0.035 12.5 0.0 0.058 11.8 0.0 1.2 1 0 0 1 1 1 0 Exocyst complex component Sec6 V_ATPase_I PF01496.19 KOS18267.1 - 0.07 11.0 4.2 0.057 11.4 1.2 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 KOS18267.1 - 0.12 12.4 9.0 0.024 14.7 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 KOS18267.1 - 0.32 9.6 3.8 1.8 7.1 1.9 2.2 2 0 0 2 2 2 0 Flagellar Assembly Protein A Laminin_II PF06009.12 KOS18267.1 - 1 9.4 10.4 1.2 9.2 0.5 2.9 2 1 1 3 3 3 0 Laminin Domain II DUF812 PF05667.11 KOS18267.1 - 1.9 7.3 15.3 5.1 5.8 15.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF3450 PF11932.8 KOS18267.1 - 2.6 7.3 11.9 0.074 12.3 4.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4618 PF15397.6 KOS18267.1 - 2.6 7.4 11.0 3.9 6.8 4.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Sigma70_ner PF04546.13 KOS18267.1 - 4.1 7.2 20.6 0.03 14.2 5.0 3.3 3 0 0 3 3 3 0 Sigma-70, non-essential region Mod_r PF07200.13 KOS18267.1 - 6.4 6.9 21.7 0.031 14.4 5.0 3.1 3 0 0 3 3 2 0 Modifier of rudimentary (Mod(r)) protein FlxA PF14282.6 KOS18267.1 - 6.8 6.7 12.4 0.11 12.5 1.6 3.4 2 1 0 2 2 2 0 FlxA-like protein Atg14 PF10186.9 KOS18267.1 - 8.2 5.4 11.3 3.8 6.5 4.0 2.8 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA_13 PF13166.6 KOS18267.1 - 8.4 4.9 10.5 0.31 9.6 3.0 1.7 1 1 0 1 1 1 0 AAA domain Reticulon PF02453.17 KOS18268.1 - 3.4e-27 95.3 5.0 1.4e-25 90.1 3.6 2.1 2 0 0 2 2 2 2 Reticulon CBP PF12192.8 KOS18268.1 - 0.032 14.4 0.2 0.088 13.0 0.2 1.7 1 0 0 1 1 1 0 Fungal calcium binding protein Ion_trans PF00520.31 KOS18269.1 - 2e-06 27.3 29.5 6.2e-06 25.6 29.5 1.8 1 1 0 1 1 1 1 Ion transport protein DNA_topoisoIV PF00521.20 KOS18270.1 - 2.8e-120 402.1 0.0 7.2e-120 400.7 0.0 1.7 1 0 0 1 1 1 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 KOS18270.1 - 1.9e-47 160.7 4.6 6.9e-47 158.9 4.6 2.1 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 KOS18270.1 - 5.8e-24 84.5 0.4 1.2e-23 83.5 0.4 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 KOS18270.1 - 3.6e-11 43.5 0.0 9.5e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 KOS18270.1 - 1.2e-06 28.7 0.0 5.2e-06 26.6 0.0 2.2 1 0 0 1 1 1 1 Toprim domain RelB_N PF18506.1 KOS18270.1 - 0.043 13.6 2.7 0.12 12.2 2.7 1.7 1 0 0 1 1 1 0 RelB Antitoxin alpha helical domain PulG PF11773.8 KOS18270.1 - 0.22 11.4 0.1 0.79 9.6 0.1 2.0 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin TAP42 PF04177.12 KOS18271.1 - 7.2e-96 321.1 0.0 8.1e-96 320.9 0.0 1.0 1 0 0 1 1 1 1 TAP42-like family KBP_C PF12309.8 KOS18271.1 - 0.018 14.6 0.0 0.028 14.0 0.0 1.2 1 0 0 1 1 1 0 KIF-1 binding protein C terminal DEK_C PF08766.11 KOS18273.1 - 0.0025 17.7 0.5 0.038 13.9 0.5 2.6 1 1 0 1 1 1 1 DEK C terminal domain PKcGMP_CC PF16808.5 KOS18273.1 - 1.5 8.7 5.0 3.7 7.5 0.0 3.6 4 0 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Gpi1 PF05024.15 KOS18274.1 - 2.1e-76 256.2 6.5 4.4e-76 255.1 6.5 1.6 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) 7tm_1 PF00001.21 KOS18274.1 - 0.00026 20.4 0.7 0.00072 19.0 0.7 1.7 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Sof1 PF04158.14 KOS18274.1 - 0.15 12.3 0.1 0.26 11.6 0.1 1.3 1 0 0 1 1 1 0 Sof1-like domain Trypan_PARP PF05887.11 KOS18275.1 - 0.0013 18.8 0.8 0.0013 18.8 0.8 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) TBCC PF07986.12 KOS18276.1 - 2.3e-29 101.6 0.0 4.1e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 KOS18276.1 - 3.5e-09 37.1 0.2 7.5e-09 36.1 0.2 1.4 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain F_actin_bind PF08919.10 KOS18276.1 - 0.047 13.8 0.3 0.41 10.8 0.0 2.1 1 1 1 2 2 2 0 F-actin binding Med9 PF07544.13 KOS18277.1 - 2.1e-18 66.2 0.3 3.9e-18 65.3 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 Spc29 PF17082.5 KOS18277.1 - 0.002 18.0 0.1 0.0027 17.6 0.1 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 PEP-utilisers_N PF05524.13 KOS18277.1 - 0.022 14.9 0.1 0.031 14.4 0.1 1.4 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal Phage_GP20 PF06810.11 KOS18277.1 - 0.032 14.0 0.0 0.042 13.6 0.0 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 Med21 PF11221.8 KOS18277.1 - 0.058 13.7 0.2 0.085 13.1 0.2 1.2 1 0 0 1 1 1 0 Subunit 21 of Mediator complex UPF0242 PF06785.11 KOS18277.1 - 0.22 11.6 0.4 0.29 11.2 0.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 KOS18277.1 - 0.88 10.2 4.1 4.5 8.0 4.2 2.1 1 1 0 1 1 1 0 SlyX iPGM_N PF06415.13 KOS18278.1 - 6e-77 257.9 0.0 8e-77 257.5 0.0 1.2 1 0 0 1 1 1 1 BPG-independent PGAM N-terminus (iPGM_N) Metalloenzyme PF01676.18 KOS18278.1 - 9.4e-63 211.9 0.0 1.2e-62 211.5 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 KOS18278.1 - 1.3e-05 24.8 0.0 0.00026 20.5 0.0 2.2 1 1 0 1 1 1 1 Sulfatase AP_endonuc_2 PF01261.24 KOS18278.1 - 0.022 14.2 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Prenylcys_lyase PF07156.14 KOS18279.1 - 8.7e-87 291.6 0.0 1.2e-86 291.1 0.0 1.0 1 0 0 1 1 1 1 Prenylcysteine lyase NAD_binding_8 PF13450.6 KOS18279.1 - 6.9e-10 39.0 0.5 1.7e-09 37.7 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOS18279.1 - 1.6e-09 37.6 0.0 2.3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 KOS18279.1 - 0.047 13.3 0.6 0.13 11.8 0.2 1.8 2 1 0 2 2 2 0 FAD dependent oxidoreductase DUF3767 PF12597.8 KOS18281.1 - 6e-38 128.7 0.1 6e-38 128.7 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3767) CCB1 PF12046.8 KOS18281.1 - 0.0043 16.4 0.0 0.0057 16.0 0.0 1.2 1 0 0 1 1 1 1 Cofactor assembly of complex C subunit B Aldose_epim PF01263.20 KOS18282.1 - 7.9e-62 209.3 0.0 9.3e-62 209.0 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase ABC_tran PF00005.27 KOS18283.1 - 1.2e-31 110.1 1.7 1.3e-19 71.1 0.0 2.7 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOS18283.1 - 2.3e-07 30.9 4.1 0.24 11.2 0.1 3.4 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran_Xtn PF12848.7 KOS18283.1 - 1.9e-06 27.8 3.2 1.9e-06 27.8 3.2 2.5 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 KOS18283.1 - 1.7e-05 24.4 5.7 0.023 14.1 0.0 4.0 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain MeaB PF03308.16 KOS18283.1 - 0.0087 15.1 0.2 0.018 14.0 0.2 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MMR_HSR1 PF01926.23 KOS18283.1 - 0.022 14.8 0.1 0.097 12.8 0.1 2.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 KOS18283.1 - 0.024 14.7 0.1 0.024 14.7 0.1 2.2 3 0 0 3 3 3 0 Dynamin family AAA_33 PF13671.6 KOS18283.1 - 0.048 13.8 0.3 0.23 11.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOS18283.1 - 0.06 13.1 0.3 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Vfa1 PF08432.10 KOS18283.1 - 0.12 12.7 0.2 0.12 12.7 0.2 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 AAA_22 PF13401.6 KOS18283.1 - 0.24 11.7 1.3 1.1 9.6 0.3 2.7 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOS18283.1 - 1.1 9.8 4.4 0.46 11.0 0.2 2.7 4 0 0 4 4 3 0 AAA domain AAA_23 PF13476.6 KOS18283.1 - 1.5 9.3 14.1 0.3 11.6 0.3 3.1 3 0 0 3 3 3 0 AAA domain NDT80_PhoG PF05224.12 KOS18285.1 - 3.7e-42 144.6 0.0 5e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family LRR_4 PF12799.7 KOS18286.1 - 0.35 11.4 1.5 17 6.0 0.0 3.6 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) Abhydrolase_1 PF00561.20 KOS18287.1 - 2e-20 73.5 0.0 4.4e-20 72.4 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS18287.1 - 1.9e-15 56.8 0.0 8.1e-15 54.7 0.0 2.0 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOS18287.1 - 1.5e-13 51.9 0.2 8.7e-13 49.4 0.0 2.2 2 1 0 2 2 2 1 Alpha/beta hydrolase family DUF915 PF06028.11 KOS18287.1 - 3.4e-05 23.3 0.0 6.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF915) Esterase PF00756.20 KOS18287.1 - 0.00018 21.2 0.1 0.0004 20.1 0.1 1.6 1 1 0 1 1 1 1 Putative esterase Abhydrolase_2 PF02230.16 KOS18287.1 - 0.0015 18.4 0.0 0.025 14.4 0.0 2.4 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase BAAT_C PF08840.11 KOS18287.1 - 0.02 14.8 0.0 0.88 9.4 0.0 2.2 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Lipase_3 PF01764.25 KOS18287.1 - 0.033 14.1 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) LIDHydrolase PF10230.9 KOS18287.1 - 0.076 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Abhydrolase_3 PF07859.13 KOS18287.1 - 0.081 12.8 0.0 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 KOS18287.1 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family Thioesterase PF00975.20 KOS18287.1 - 0.13 12.4 0.0 0.4 10.8 0.0 1.8 2 0 0 2 2 2 0 Thioesterase domain Chlorophyllase2 PF12740.7 KOS18287.1 - 0.16 10.8 0.0 0.27 10.1 0.0 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme PEP_mutase PF13714.6 KOS18288.1 - 6.2e-35 120.8 1.2 7e-35 120.6 1.2 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 KOS18288.1 - 4.5e-17 61.7 0.2 5.3e-17 61.5 0.2 1.2 1 0 0 1 1 1 1 Isocitrate lyase family TRM PF02005.16 KOS18289.1 - 6e-103 344.9 0.0 2e-91 307.0 0.0 2.0 2 0 0 2 2 2 2 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 KOS18289.1 - 0.034 13.9 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein Spo7 PF03907.13 KOS18290.1 - 4.5e-95 317.3 0.1 5.9e-95 316.9 0.1 1.1 1 0 0 1 1 1 1 Spo7-like protein DUF485 PF04341.12 KOS18290.1 - 0.75 9.8 2.9 0.89 9.6 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF485 HET PF06985.11 KOS18291.1 - 6.8e-24 84.9 0.0 4.7e-23 82.1 0.0 2.3 2 1 0 2 2 2 1 Heterokaryon incompatibility protein (HET) RSN1_7TM PF02714.15 KOS18292.1 - 5.8e-74 248.8 26.1 5.8e-74 248.8 26.1 1.8 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOS18292.1 - 4.9e-43 146.6 2.4 4.9e-43 146.6 2.4 4.0 3 1 1 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOS18292.1 - 6.7e-28 98.1 4.2 5.5e-17 62.6 0.2 2.3 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 KOS18292.1 - 8.3e-17 61.1 0.0 2e-16 59.9 0.0 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter DUF4638 PF15472.6 KOS18292.1 - 3 7.5 10.0 0.043 13.6 2.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4638) SRP68 PF16969.5 KOS18293.1 - 3.8e-193 643.5 6.5 4.3e-193 643.3 6.5 1.0 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 Mis14 PF08641.12 KOS18293.1 - 0.011 16.0 0.1 0.03 14.7 0.1 1.6 1 0 0 1 1 1 0 Kinetochore protein Mis14 like HSP70 PF00012.20 KOS18294.1 - 6.9e-266 883.2 13.3 7.9e-266 883.0 13.3 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS18294.1 - 2.1e-14 53.1 4.1 2e-12 46.6 1.1 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 KOS18294.1 - 0.00087 19.1 0.0 0.0029 17.4 0.0 1.9 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain SMBP PF16785.5 KOS18294.1 - 0.13 12.5 4.0 0.11 12.7 1.8 2.2 2 0 0 2 2 2 0 Small metal-binding protein Herpes_UL14 PF03580.14 KOS18294.1 - 0.3 11.3 5.1 0.73 10.1 5.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL14-like protein Tom22 PF04281.13 KOS18294.1 - 0.34 10.7 3.9 0.86 9.4 3.9 1.7 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 FtsA PF14450.6 KOS18294.1 - 7.6 7.0 13.3 4.7 7.7 0.6 4.3 3 3 0 3 3 3 0 Cell division protein FtsA GCP_N_terminal PF17681.1 KOS18295.1 - 1.3e-62 212.2 0.0 2.3e-62 211.4 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOS18295.1 - 9.7e-62 209.2 0.7 1.3e-61 208.8 0.1 1.5 2 0 0 2 2 2 1 Gamma tubulin complex component C-terminal MLIP PF15274.6 KOS18295.1 - 0.022 14.7 0.2 0.067 13.1 0.0 1.8 2 0 0 2 2 2 0 Muscular LMNA-interacting protein SNF2_N PF00176.23 KOS18296.1 - 3.4e-71 239.8 0.0 5.5e-71 239.1 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS18296.1 - 2.6e-12 47.1 0.0 8e-12 45.5 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS18296.1 - 9.1e-06 25.5 0.0 1.8e-05 24.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-RING_5 PF14634.6 KOS18296.1 - 1.3e-05 25.1 1.9 2.9e-05 23.9 1.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KOS18296.1 - 0.00099 19.4 0.5 0.0032 17.8 0.5 1.9 1 0 0 1 1 1 1 Ring finger domain ResIII PF04851.15 KOS18296.1 - 0.0027 17.7 0.0 0.0099 15.9 0.0 1.9 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit zf-C3HC4 PF00097.25 KOS18296.1 - 0.0043 16.9 1.4 0.012 15.4 1.4 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS18296.1 - 0.023 14.7 2.0 0.12 12.4 2.2 2.1 1 1 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 KOS18296.1 - 0.043 13.7 4.6 0.14 12.0 4.6 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOS18296.1 - 0.89 9.5 5.3 5.1 7.0 5.4 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) PH PF00169.29 KOS18297.1 - 0.048 14.2 0.0 0.19 12.3 0.0 2.0 2 1 0 2 2 2 0 PH domain DUF4690 PF15756.5 KOS18298.1 - 0.025 15.2 2.4 0.048 14.3 1.8 1.7 2 0 0 2 2 2 0 Small Novel Rich in Cartilage CD34_antigen PF06365.12 KOS18298.1 - 0.052 13.1 0.0 0.079 12.5 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family TMEM100 PF16311.5 KOS18298.1 - 0.075 12.6 1.0 0.14 11.7 1.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 100 Rax2 PF12768.7 KOS18298.1 - 0.13 11.7 0.1 0.19 11.2 0.1 1.2 1 0 0 1 1 1 0 Cortical protein marker for cell polarity DUF2415 PF10313.9 KOS18299.1 - 6.3e-13 48.4 0.2 6.4e-12 45.2 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) ANAPC4_WD40 PF12894.7 KOS18299.1 - 0.048 14.0 0.0 32 4.9 0.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DAO PF01266.24 KOS18300.1 - 2.9e-60 204.7 6.3 3.6e-60 204.4 6.3 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS18300.1 - 2.2e-06 27.8 0.1 6.5e-06 26.3 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOS18300.1 - 0.0004 19.7 0.8 0.0012 18.2 0.2 1.9 2 0 0 2 2 2 1 Thi4 family Lycopene_cycl PF05834.12 KOS18300.1 - 0.033 13.2 0.2 0.056 12.5 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 KOS18300.1 - 0.061 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOS18300.1 - 0.12 11.6 0.1 0.22 10.7 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS18300.1 - 0.14 11.3 0.1 0.23 10.7 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 KOS18300.1 - 0.17 11.2 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 GMC oxidoreductase Fungal_trans_2 PF11951.8 KOS18301.1 - 0.15 10.9 0.4 0.2 10.4 0.4 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Proteasome PF00227.26 KOS18302.1 - 4e-56 189.5 0.1 5.2e-56 189.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOS18302.1 - 3.2e-10 39.5 0.0 6.9e-10 38.4 0.0 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ribosomal_L37e PF01907.19 KOS18303.1 - 5.4e-12 45.7 2.9 1.2e-11 44.6 2.9 1.6 1 0 0 1 1 1 1 Ribosomal protein L37e ApbA PF02558.16 KOS18304.1 - 3.8e-26 91.6 0.0 5.7e-26 91.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 KOS18304.1 - 2e-17 63.5 0.0 3e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal Sel1 PF08238.12 KOS18306.1 - 8.5e-46 153.4 23.4 2.2e-08 34.5 0.0 7.7 8 0 0 8 8 8 7 Sel1 repeat MFS_1 PF07690.16 KOS18307.1 - 1e-37 129.9 33.2 3.6e-26 91.9 13.2 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS18307.1 - 9.6e-13 47.8 2.1 9.6e-13 47.8 2.1 2.9 2 1 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 KOS18307.1 - 0.00013 20.5 4.7 0.00013 20.5 4.7 1.5 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) ELP6 PF09807.9 KOS18308.1 - 2.7e-05 23.7 0.2 6.9e-05 22.4 0.2 1.7 1 1 0 1 1 1 1 Elongation complex protein 6 A_deamin PF02137.18 KOS18309.1 - 8.1e-25 88.0 0.0 6.8e-24 84.9 0.0 2.0 1 1 0 1 1 1 1 Adenosine-deaminase (editase) domain NAC PF01849.18 KOS18310.1 - 4.2e-23 81.1 0.8 6.7e-23 80.4 0.2 1.6 2 0 0 2 2 2 1 NAC domain T3SSipB PF16535.5 KOS18310.1 - 0.033 14.7 0.4 1.8 9.0 0.0 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB Sigma70_r3 PF04539.16 KOS18310.1 - 0.074 13.1 1.2 0.12 12.5 0.3 1.8 2 0 0 2 2 2 0 Sigma-70 region 3 OPT PF03169.15 KOS18311.1 - 3.6e-169 564.3 56.9 4.1e-169 564.1 56.9 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4191 PF13829.6 KOS18311.1 - 0.023 14.0 0.7 0.093 12.1 0.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) CBP4 PF07960.11 KOS18312.1 - 3.5e-27 94.8 2.2 4.1e-27 94.6 2.2 1.0 1 0 0 1 1 1 1 CBP4 DUF1266 PF06889.11 KOS18312.1 - 0.12 12.4 2.6 0.15 12.1 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1266) PKK PF12474.8 KOS18312.1 - 0.21 11.7 9.4 0.26 11.4 9.4 1.1 1 0 0 1 1 1 0 Polo kinase kinase DUF2852 PF11014.8 KOS18312.1 - 0.8 9.9 5.8 0.34 11.1 2.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) FA_desaturase PF00487.24 KOS18313.1 - 1e-29 104.2 24.2 1.5e-29 103.6 24.2 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOS18313.1 - 1.2e-10 41.4 0.0 2.2e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Xpo1 PF08389.12 KOS18313.1 - 0.12 12.4 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Exportin 1-like protein Pyr_redox_2 PF07992.14 KOS18314.1 - 2.9e-65 220.4 6.3 4e-65 219.9 6.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOS18314.1 - 1.8e-40 137.6 2.0 5.1e-40 136.2 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOS18314.1 - 1.3e-21 76.9 9.3 1.4e-20 73.7 1.7 2.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS18314.1 - 3.3e-10 40.1 2.8 1.4e-05 25.3 0.5 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 KOS18314.1 - 9e-09 35.2 9.8 2.1e-08 34.0 0.5 2.5 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 KOS18314.1 - 1e-08 34.7 9.6 3.7e-06 26.3 4.9 2.8 2 1 0 2 2 2 2 Glucose inhibited division protein A FAD_binding_2 PF00890.24 KOS18314.1 - 9.8e-08 31.5 10.9 2e-06 27.2 3.0 3.3 3 0 0 3 3 3 2 FAD binding domain Pyr_redox_3 PF13738.6 KOS18314.1 - 1.7e-07 30.8 6.2 1.3e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS18314.1 - 1.7e-06 27.5 4.7 0.0067 15.7 0.5 2.7 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 KOS18314.1 - 1.4e-05 24.0 14.4 0.00045 19.0 2.5 4.0 4 0 0 4 4 4 2 HI0933-like protein Thi4 PF01946.17 KOS18314.1 - 4.8e-05 22.7 3.3 0.0016 17.7 0.1 2.4 2 0 0 2 2 2 1 Thi4 family K_oxygenase PF13434.6 KOS18314.1 - 0.00025 20.3 2.1 0.16 11.1 0.0 2.5 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 KOS18314.1 - 0.0004 20.1 15.5 0.013 15.2 0.5 4.0 4 0 0 4 4 4 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 KOS18314.1 - 0.00061 19.1 7.9 0.052 12.8 0.7 2.5 2 1 0 2 2 2 2 FAD binding domain Lycopene_cycl PF05834.12 KOS18314.1 - 0.0019 17.3 4.0 0.096 11.7 0.3 2.8 2 1 0 2 2 2 2 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 KOS18314.1 - 0.032 13.6 1.1 1.5 8.2 0.3 2.4 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 KOS18314.1 - 0.04 14.4 3.3 0.57 10.7 1.0 2.9 2 1 0 2 2 2 0 Putative NAD(P)-binding RuBisCO_large PF00016.20 KOS18314.1 - 0.36 10.0 4.4 3 6.9 0.1 3.1 3 0 0 3 3 3 0 Ribulose bisphosphate carboxylase large chain, catalytic domain Trp_halogenase PF04820.14 KOS18314.1 - 1.1 8.0 6.3 0.78 8.5 1.0 2.1 2 0 0 2 2 2 0 Tryptophan halogenase 3HCDH_N PF02737.18 KOS18314.1 - 6.5 6.6 8.8 0.21 11.4 0.6 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DnaJ PF00226.31 KOS18316.1 - 3.5e-21 75.1 3.2 1.2e-20 73.3 3.2 2.0 1 0 0 1 1 1 1 DnaJ domain TPR_1 PF00515.28 KOS18316.1 - 1.5e-16 59.4 0.6 0.0043 16.8 0.0 6.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18316.1 - 1.5e-16 59.0 2.5 0.082 13.1 0.0 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOS18316.1 - 5e-14 52.2 0.8 0.0011 19.1 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOS18316.1 - 4.7e-13 48.5 0.2 0.0001 22.5 0.1 4.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOS18316.1 - 7.8e-13 48.7 0.3 0.00028 21.3 0.2 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS18316.1 - 9e-13 47.4 0.2 0.013 15.7 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18316.1 - 2e-10 41.2 0.7 0.13 13.0 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOS18316.1 - 4e-10 39.7 6.6 0.29 12.0 0.0 6.9 4 3 4 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS18316.1 - 4.7e-08 32.6 2.5 0.032 13.9 0.0 5.3 2 2 3 5 5 5 3 TPR repeat TPR_7 PF13176.6 KOS18316.1 - 2.9e-06 26.9 3.9 0.52 10.5 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS18316.1 - 4.6e-06 26.8 7.8 2.4 8.5 0.2 5.2 5 1 0 5 5 4 2 Tetratricopeptide repeat PknG_TPR PF16918.5 KOS18316.1 - 4.1e-05 22.5 0.4 0.0033 16.2 0.1 2.9 3 0 0 3 3 3 1 Protein kinase G tetratricopeptide repeat TPR_6 PF13174.6 KOS18316.1 - 0.00012 22.5 6.5 13 6.7 0.0 6.1 7 0 0 7 7 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS18316.1 - 0.00052 20.2 6.6 0.79 10.0 0.0 4.4 5 1 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 KOS18316.1 - 0.0082 16.5 0.5 6.2 7.2 0.0 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2379 PF09543.10 KOS18316.1 - 0.025 14.8 0.6 32 4.7 0.1 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2379) PPTA PF01239.22 KOS18316.1 - 0.25 11.1 0.4 1.8 8.4 0.0 2.6 3 0 0 3 3 3 0 Protein prenyltransferase alpha subunit repeat Alkyl_sulf_dimr PF14863.6 KOS18316.1 - 0.44 11.0 3.7 22 5.5 0.0 3.4 3 1 1 4 4 4 0 Alkyl sulfatase dimerisation ORF6C PF10552.9 KOS18316.1 - 1.1 9.3 5.8 21 5.2 1.8 2.7 1 1 1 2 2 2 0 ORF6C domain Ribosomal_S20p PF01649.18 KOS18316.1 - 1.5 9.5 8.2 13 6.5 5.4 2.7 1 1 1 2 2 2 0 Ribosomal protein S20 SHOCT PF09851.9 KOS18316.1 - 2.2 8.1 4.0 6.4 6.6 0.7 2.9 2 0 0 2 2 2 0 Short C-terminal domain HemY_N PF07219.13 KOS18316.1 - 2.7 8.2 6.5 1.2 9.4 0.9 3.1 2 1 2 4 4 4 0 HemY protein N-terminus Laminin_II PF06009.12 KOS18317.1 - 0.043 13.8 0.2 0.081 12.9 0.2 1.4 1 0 0 1 1 1 0 Laminin Domain II CRISPR_Cas2 PF09827.9 KOS18317.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 CRISPR associated protein Cas2 SlyX PF04102.12 KOS18317.1 - 1.1 9.9 7.0 16 6.2 0.0 3.3 3 1 1 4 4 4 0 SlyX PspB PF06667.12 KOS18317.1 - 2.5 8.2 9.1 0.95 9.6 0.2 3.1 4 0 0 4 4 4 0 Phage shock protein B Vac14_Fig4_bd PF11916.8 KOS18318.1 - 6.1e-80 267.1 4.8 6.1e-80 267.1 4.8 2.0 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 KOS18318.1 - 5.5e-43 145.5 0.1 1.2e-39 134.8 0.0 3.5 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 KOS18318.1 - 2.3e-07 30.5 0.4 0.011 15.9 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 KOS18318.1 - 3.2e-06 27.3 0.2 0.038 14.0 0.2 3.7 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 KOS18318.1 - 5.6e-06 26.7 4.3 0.0043 17.5 0.0 4.9 4 0 0 4 4 4 1 HEAT-like repeat Arm PF00514.23 KOS18318.1 - 0.0019 18.2 0.0 1.4 9.0 0.0 4.5 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOS18318.1 - 0.015 15.7 3.2 11 6.5 0.0 5.0 6 1 0 6 6 6 0 HEAT repeats DUF4954 PF16314.5 KOS18319.1 - 0.079 11.1 2.0 0.11 10.6 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Glyoxalase PF00903.25 KOS18319.1 - 0.15 12.2 0.0 2.7 8.2 0.0 2.2 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EMG1 PF03587.14 KOS18320.1 - 8.5e-79 263.7 0.2 9.9e-79 263.5 0.2 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Ribosomal_S17 PF00366.20 KOS18321.1 - 1.2e-21 76.6 2.4 2.3e-21 75.7 2.4 1.5 1 0 0 1 1 1 1 Ribosomal protein S17 RR_TM4-6 PF06459.12 KOS18321.1 - 0.008 16.0 2.1 0.0097 15.8 2.1 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Borrelia_P83 PF05262.11 KOS18321.1 - 0.014 13.9 1.0 0.015 13.8 1.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein NARP1 PF12569.8 KOS18321.1 - 0.059 12.3 5.1 0.068 12.1 5.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Rtf2 PF04641.12 KOS18321.1 - 0.13 11.6 4.0 0.17 11.2 4.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PXA PF02194.15 KOS18322.1 - 5.1e-42 143.9 0.4 6.3e-42 143.6 0.4 1.1 1 0 0 1 1 1 1 PXA domain zf-Mss51 PF13824.6 KOS18323.1 - 2.8e-27 94.6 4.9 4.9e-27 93.8 4.9 1.4 1 0 0 1 1 1 1 Zinc-finger of mitochondrial splicing suppressor 51 zf-MYND PF01753.18 KOS18323.1 - 0.0014 18.6 0.9 0.0023 18.0 0.9 1.3 1 0 0 1 1 1 1 MYND finger MMS1_N PF10433.9 KOS18324.1 - 3.6e-159 530.5 0.0 5.4e-159 529.9 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KOS18324.1 - 2.7e-103 345.7 0.0 8e-103 344.1 0.0 1.9 1 0 0 1 1 1 1 CPSF A subunit region UBA_4 PF14555.6 KOS18325.1 - 8.8e-05 22.2 0.0 0.00017 21.3 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain LysM PF01476.20 KOS18325.1 - 0.0051 16.8 0.0 0.0083 16.2 0.0 1.4 1 0 0 1 1 1 1 LysM domain FAP PF07174.11 KOS18325.1 - 0.62 9.5 8.7 0.84 9.0 8.7 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF2040 PF09745.9 KOS18326.1 - 4.8e-39 133.1 21.5 4.8e-39 133.1 21.5 3.4 4 0 0 4 4 4 1 Coiled-coil domain-containing protein 55 (DUF2040) zf-Tim10_DDP PF02953.15 KOS18327.1 - 3.1e-22 78.0 1.0 3.9e-22 77.7 1.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF2116 PF09889.9 KOS18327.1 - 0.11 12.5 2.5 0.44 10.6 0.4 2.2 1 1 1 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Lectin_leg-like PF03388.13 KOS18328.1 - 8.2e-65 218.4 0.0 1e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 Legume-like lectin family Lectin_legB PF00139.19 KOS18328.1 - 1.4e-05 24.8 0.0 0.15 11.6 0.0 2.1 2 0 0 2 2 2 2 Legume lectin domain MFS_Mycoplasma PF07672.13 KOS18329.1 - 0.071 12.4 0.2 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 Mycoplasma MFS transporter MMR_HSR1_Xtn PF16897.5 KOS18331.1 - 1.7e-41 140.5 1.4 2.7e-40 136.7 0.4 2.3 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KOS18331.1 - 2e-22 79.0 0.1 3.9e-22 78.1 0.1 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KOS18331.1 - 7.3e-21 74.4 0.0 2.5e-20 72.7 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS18331.1 - 2.4e-09 36.9 0.0 1.3e-08 34.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS18331.1 - 0.00019 21.6 0.1 0.051 13.6 0.0 2.5 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 KOS18331.1 - 0.00032 20.3 0.1 5.1 6.6 0.0 3.9 2 2 1 3 3 3 2 Elongation factor Tu GTP binding domain MeaB PF03308.16 KOS18331.1 - 0.01 14.9 0.1 0.026 13.5 0.1 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 KOS18331.1 - 0.04 13.8 0.8 6 6.7 0.0 3.1 3 1 1 4 4 4 0 RsgA GTPase AIG1 PF04548.16 KOS18331.1 - 0.075 12.4 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 AIG1 family AAA_22 PF13401.6 KOS18331.1 - 0.11 12.8 0.0 1.1 9.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain DUF1524 PF07510.11 KOS18332.1 - 4.8e-07 29.7 0.0 6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1524) Cellulase PF00150.18 KOS18333.1 - 6.7e-21 74.9 3.1 9.2e-21 74.5 3.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_42 PF02449.15 KOS18333.1 - 0.0027 17.1 0.3 0.033 13.5 0.1 2.0 2 0 0 2 2 2 1 Beta-galactosidase Glyco_hydro_2_C PF02836.17 KOS18333.1 - 0.062 12.4 0.0 0.11 11.6 0.0 1.4 1 1 0 1 1 1 0 Glycosyl hydrolases family 2, TIM barrel domain Mlh1_C PF16413.5 KOS18334.1 - 3.3e-98 328.3 0.0 5.1e-98 327.7 0.0 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 KOS18334.1 - 9e-33 112.5 0.0 1.7e-32 111.6 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 KOS18334.1 - 2.3e-12 46.9 0.1 4.9e-12 45.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 KOS18334.1 - 3.7e-07 30.6 0.0 1e-06 29.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HoxA13_N PF12284.8 KOS18334.1 - 0.018 15.7 0.3 0.045 14.4 0.3 1.6 1 0 0 1 1 1 0 Hox protein A13 N terminal Lon_C PF05362.13 KOS18335.1 - 1.7e-67 226.9 0.1 3.4e-67 225.9 0.1 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 KOS18335.1 - 8.4e-23 81.3 0.0 1.5e-22 80.5 0.0 1.5 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 KOS18335.1 - 5e-22 78.7 0.0 1.2e-21 77.5 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 KOS18335.1 - 2.7e-08 33.9 0.0 7.3e-08 32.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 KOS18335.1 - 4.7e-08 32.9 0.1 5.8e-07 29.4 0.0 2.5 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_16 PF13191.6 KOS18335.1 - 1.1e-05 25.9 0.9 6.4e-05 23.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_3 PF07726.11 KOS18335.1 - 5.1e-05 23.2 0.0 0.00013 21.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOS18335.1 - 0.0002 21.1 0.1 0.00091 19.0 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOS18335.1 - 0.00033 20.8 0.0 0.00094 19.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOS18335.1 - 0.00036 20.8 0.0 0.017 15.4 0.0 2.7 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOS18335.1 - 0.0025 17.6 0.0 0.0075 16.0 0.0 1.8 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOS18335.1 - 0.0051 16.2 0.3 0.11 11.9 0.2 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOS18335.1 - 0.0076 16.4 0.0 0.02 15.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOS18335.1 - 0.008 16.1 0.0 0.028 14.3 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_23 PF13476.6 KOS18335.1 - 0.0085 16.6 0.4 0.034 14.6 0.0 2.1 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 KOS18335.1 - 0.013 15.9 0.0 0.036 14.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 KOS18335.1 - 0.029 14.9 0.0 0.076 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOS18335.1 - 0.031 14.3 0.0 0.058 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOS18335.1 - 0.033 13.8 0.1 0.18 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KOS18335.1 - 0.055 12.6 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain TIP49 PF06068.13 KOS18335.1 - 0.069 12.3 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_24 PF13479.6 KOS18335.1 - 0.083 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOS18335.1 - 0.1 12.1 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 KOS18335.1 - 0.11 13.0 0.0 0.36 11.3 0.0 1.8 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 KOS18335.1 - 0.12 12.3 0.1 0.31 11.0 0.1 1.7 1 1 0 1 1 1 0 NTPase AAA_17 PF13207.6 KOS18335.1 - 0.14 12.6 0.1 0.49 10.8 0.1 2.0 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOS18335.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 KOS18335.1 - 0.16 12.0 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RPA_C PF08784.11 KOS18336.1 - 1.2e-13 51.7 0.3 2.5e-13 50.6 0.0 1.7 2 0 0 2 2 2 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 KOS18336.1 - 6.6e-09 35.6 0.0 1.5e-08 34.4 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain AP3D1 PF06375.11 KOS18336.1 - 0.018 15.3 10.0 0.026 14.7 10.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TraV PF09676.10 KOS18336.1 - 0.022 15.8 3.4 5.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) DFRP_C PF16543.5 KOS18336.1 - 0.023 15.2 6.0 0.21 12.1 6.3 2.1 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Tubulin_3 PF14881.6 KOS18336.1 - 0.047 13.4 0.6 0.12 12.1 0.6 1.6 1 0 0 1 1 1 0 Tubulin domain DUF1892 PF08987.10 KOS18336.1 - 0.051 13.8 0.3 0.081 13.1 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1892) SART-1 PF03343.13 KOS18336.1 - 0.051 12.1 7.1 0.065 11.8 7.1 1.1 1 0 0 1 1 1 0 SART-1 family NPR3 PF03666.13 KOS18336.1 - 0.083 11.7 3.6 0.13 11.0 3.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SR-25 PF10500.9 KOS18336.1 - 0.1 12.2 13.1 0.15 11.6 13.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Protocadherin PF08374.11 KOS18336.1 - 0.14 12.1 2.3 0.2 11.6 2.3 1.2 1 0 0 1 1 1 0 Protocadherin Peptidase_S49_N PF08496.10 KOS18336.1 - 1.3 9.0 10.3 2.3 8.3 10.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal GATA PF00320.27 KOS18337.1 - 2.3e-15 55.9 2.7 4.1e-15 55.1 2.7 1.4 1 0 0 1 1 1 1 GATA zinc finger Macoilin PF09726.9 KOS18337.1 - 1.8e-06 26.8 26.1 2.4e-06 26.5 26.1 1.1 1 0 0 1 1 1 1 Macoilin family NARP1 PF12569.8 KOS18337.1 - 0.0013 17.7 6.2 0.0013 17.7 6.2 2.2 2 0 0 2 2 1 1 NMDA receptor-regulated protein 1 Spt20 PF12090.8 KOS18337.1 - 0.011 15.4 30.2 0.027 14.1 30.2 1.8 1 0 0 1 1 1 0 Spt20 family TF_Zn_Ribbon PF08271.12 KOS18337.1 - 0.045 13.3 0.8 0.1 12.1 0.8 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding SelP_N PF04592.14 KOS18337.1 - 0.12 11.8 20.0 0.013 14.9 15.3 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Atg14 PF10186.9 KOS18337.1 - 0.19 10.8 29.3 0.056 12.5 10.3 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fmp27_WPPW PF10359.9 KOS18337.1 - 1.4 7.7 23.8 0.11 11.3 4.8 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Plasmodium_Vir PF05795.11 KOS18337.1 - 2.7 7.3 11.5 0.028 13.9 2.8 1.8 2 0 0 2 2 2 0 Plasmodium vivax Vir protein DUF4647 PF15504.6 KOS18337.1 - 3.4 6.7 21.8 0.072 12.2 12.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) Exonuc_VII_L PF02601.15 KOS18337.1 - 4.1 6.9 23.5 3.9 6.9 3.3 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Membralin PF09746.9 KOS18337.1 - 4.7 6.1 11.7 0.48 9.4 6.5 1.7 2 0 0 2 2 2 0 Tumour-associated protein Endostatin PF06482.11 KOS18337.1 - 5.3 6.4 19.8 0.15 11.5 12.2 1.9 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin Otopetrin PF03189.13 KOS18337.1 - 6.3 5.5 7.9 11 4.7 7.9 1.4 1 0 0 1 1 1 0 Otopetrin VIT1 PF01988.19 KOS18337.1 - 6.4 6.6 17.0 0.56 10.0 4.2 2.3 2 0 0 2 2 2 0 VIT family FAM76 PF16046.5 KOS18337.1 - 7.9 5.7 30.2 0.032 13.6 15.4 3.0 3 1 0 3 3 3 0 FAM76 protein Zip PF02535.22 KOS18337.1 - 8.3 5.5 14.9 0.19 10.9 7.8 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter SAPS PF04499.15 KOS18337.1 - 9.2 4.9 20.0 0.44 9.3 5.3 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Svf1_C PF17187.4 KOS18338.1 - 2.5e-61 206.3 0.0 4.8e-61 205.4 0.0 1.5 2 0 0 2 2 2 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 KOS18338.1 - 4.1e-52 176.5 0.0 5.6e-52 176.1 0.0 1.2 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Mit_KHE1 PF10173.9 KOS18339.1 - 5.9e-57 192.8 0.0 1.3e-56 191.8 0.0 1.5 2 0 0 2 2 2 1 Mitochondrial K+-H+ exchange-related ABC2_membrane_4 PF12730.7 KOS18339.1 - 0.22 11.5 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein NUDIX PF00293.28 KOS18340.1 - 3.6e-25 88.5 0.0 4.9e-25 88.1 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain HAD_2 PF13419.6 KOS18341.1 - 1e-08 35.5 0.0 1.5e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS18341.1 - 1.3e-08 35.4 0.0 1.2e-07 32.2 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS18341.1 - 0.06 13.8 0.0 0.079 13.3 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Med21 PF11221.8 KOS18342.1 - 5.4e-47 159.7 7.4 6e-47 159.5 7.4 1.0 1 0 0 1 1 1 1 Subunit 21 of Mediator complex BST2 PF16716.5 KOS18342.1 - 0.0082 16.7 1.4 2.3 8.8 0.4 2.3 2 0 0 2 2 2 2 Bone marrow stromal antigen 2 GAS PF13851.6 KOS18342.1 - 0.022 14.1 6.2 0.17 11.2 0.4 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med9 PF07544.13 KOS18342.1 - 0.025 14.7 0.4 0.025 14.7 0.4 2.7 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF4455 PF14643.6 KOS18342.1 - 0.13 10.9 6.6 0.032 12.9 2.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4455) TMF_DNA_bd PF12329.8 KOS18342.1 - 6.7 6.8 12.0 31 4.6 1.4 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Sec62 PF03839.16 KOS18343.1 - 1.1e-70 237.6 2.8 1.1e-70 237.6 2.8 2.0 2 0 0 2 2 2 1 Translocation protein Sec62 Acetyltransf_1 PF00583.25 KOS18344.1 - 9.2e-09 35.6 0.0 1.1e-08 35.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS18344.1 - 4.1e-07 30.0 0.0 6.2e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS18344.1 - 6.4e-07 29.3 0.1 1.1e-06 28.5 0.1 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOS18344.1 - 2.1e-06 28.0 0.0 2.9e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS18344.1 - 0.14 12.3 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PLDc_2 PF13091.6 KOS18345.1 - 2.6e-14 53.3 0.0 4.3e-05 23.4 0.0 3.7 3 1 0 3 3 3 3 PLD-like domain PLDc PF00614.22 KOS18345.1 - 2.8e-10 39.9 0.3 0.00047 20.2 0.2 2.9 2 0 0 2 2 2 2 Phospholipase D Active site motif Thioredoxin PF00085.20 KOS18346.1 - 1.2e-42 144.0 0.0 3e-23 81.8 0.0 3.6 3 1 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 KOS18346.1 - 1.8e-08 34.5 0.0 0.0022 18.0 0.0 4.1 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOS18346.1 - 1.1e-06 28.8 1.3 0.25 11.7 0.0 5.1 4 1 1 5 5 5 2 Thioredoxin-like Thioredoxin_2 PF13098.6 KOS18346.1 - 2.3e-05 24.8 0.6 0.019 15.4 0.0 3.2 2 1 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 KOS18346.1 - 7.1e-05 22.9 0.1 0.038 14.2 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 KOS18346.1 - 0.0012 18.3 0.1 0.44 9.9 0.0 2.5 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Presenilin PF01080.17 KOS18346.1 - 0.035 12.9 1.1 0.054 12.2 1.1 1.2 1 0 0 1 1 1 0 Presenilin AhpC-TSA PF00578.21 KOS18346.1 - 0.058 13.3 1.3 1.2 9.1 0.1 2.7 3 0 0 3 3 3 0 AhpC/TSA family Thioredoxin_3 PF13192.6 KOS18346.1 - 0.076 13.1 0.0 0.82 9.8 0.0 2.6 3 0 0 3 3 3 0 Thioredoxin domain TraF PF13728.6 KOS18346.1 - 0.32 10.8 0.0 0.32 10.8 0.0 3.6 3 1 1 4 4 3 0 F plasmid transfer operon protein CDC45 PF02724.14 KOS18346.1 - 3.9 5.7 13.7 6.5 4.9 13.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Tyr-DNA_phospho PF06087.12 KOS18347.1 - 1.3e-44 152.8 0.0 1.4e-44 152.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase MatE PF01554.18 KOS18348.1 - 1.7e-51 174.1 31.5 4.1e-31 107.8 12.2 2.4 2 0 0 2 2 2 2 MatE 14-3-3 PF00244.20 KOS18349.1 - 1e-05 25.2 0.0 1.4e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 14-3-3 protein WD40 PF00400.32 KOS18350.1 - 1.1e-09 38.8 2.8 0.001 19.8 0.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18350.1 - 0.026 14.8 0.0 17 5.8 0.0 3.5 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS18350.1 - 0.028 13.4 0.0 4 6.3 0.1 2.4 3 0 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Prenyltrans PF00432.21 KOS18350.1 - 0.5 10.1 4.4 3.7 7.4 0.1 3.7 4 0 0 4 4 4 0 Prenyltransferase and squalene oxidase repeat Ribosomal_60s PF00428.19 KOS18350.1 - 5.7 7.6 12.2 10 6.8 12.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein FA_desaturase PF00487.24 KOS18351.1 - 3.6e-19 69.6 9.3 3.6e-19 69.6 9.3 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 KOS18351.1 - 1.5e-17 63.5 0.1 5.5e-17 61.7 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Oleosin PF01277.17 KOS18351.1 - 0.24 11.2 2.3 0.45 10.3 0.8 2.2 2 0 0 2 2 2 0 Oleosin TFIIB PF00382.19 KOS18352.1 - 2.4e-05 24.3 0.0 0.24 11.5 0.0 2.7 2 1 0 2 2 2 2 Transcription factor TFIIB repeat Cyclin_N PF00134.23 KOS18352.1 - 0.078 12.7 0.0 0.3 10.8 0.0 2.0 2 1 0 2 2 2 0 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOS18352.1 - 0.15 12.1 3.2 4 7.6 0.2 2.6 2 1 1 3 3 3 0 Cyclin, C-terminal domain Zn_clus PF00172.18 KOS18353.1 - 0.00024 21.1 7.0 0.0041 17.2 5.2 2.4 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Sec62 PF03839.16 KOS18354.1 - 4.1 6.8 6.0 5.6 6.4 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF2034 PF10356.9 KOS18355.1 - 5.5e-30 104.2 0.0 3.7e-15 55.8 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 KOS18355.1 - 2.6e-08 33.9 0.0 4.2e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Restriction endonuclease Pkinase PF00069.25 KOS18356.1 - 7.7e-12 45.1 0.0 7.7e-11 41.9 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18356.1 - 1.6e-08 34.2 0.0 2e-07 30.5 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase SSP160 PF06933.11 KOS18356.1 - 7.1 4.7 7.4 11 4.1 7.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Lon_C PF05362.13 KOS18357.1 - 4.9e-65 218.9 0.0 8.7e-65 218.1 0.0 1.4 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 KOS18357.1 - 5.1e-33 114.7 0.1 1.3e-32 113.4 0.1 1.7 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 KOS18357.1 - 5.2e-21 75.4 0.0 1.4e-20 74.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ChlI PF13541.6 KOS18357.1 - 2e-08 34.1 0.0 5.1e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase AAA_5 PF07728.14 KOS18357.1 - 9.6e-07 28.9 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOS18357.1 - 4.6e-06 26.9 1.5 1.1e-05 25.7 0.0 2.4 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOS18357.1 - 4.9e-05 23.6 0.0 0.00049 20.4 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 KOS18357.1 - 7.6e-05 21.8 0.0 0.00016 20.8 0.0 1.4 1 0 0 1 1 1 1 PrkA AAA domain RuvB_N PF05496.12 KOS18357.1 - 7.9e-05 22.5 0.1 0.00085 19.1 0.0 2.6 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS18357.1 - 0.00086 19.7 2.2 0.0032 17.9 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 KOS18357.1 - 0.036 14.1 0.0 0.099 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain DNTTIP1_dimer PF18192.1 KOS18357.1 - 0.038 14.3 0.4 5.3 7.5 0.0 3.4 2 2 1 3 3 3 0 DNTTIP1 dimerisation domain RsgA_GTPase PF03193.16 KOS18357.1 - 0.051 13.5 0.1 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase IstB_IS21 PF01695.17 KOS18357.1 - 0.054 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 KOS18357.1 - 0.086 13.4 0.0 0.086 13.4 0.0 2.7 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 KOS18357.1 - 0.087 13.2 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 KOS18357.1 - 0.098 12.2 0.4 0.2 11.1 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 KOS18357.1 - 3.9 8.0 5.8 1.1 9.8 0.1 2.8 3 0 0 3 3 3 0 ABC transporter MOR2-PAG1_N PF14222.6 KOS18358.1 - 3.9e-216 719.3 0.0 1e-215 717.9 0.0 1.7 2 0 0 2 2 2 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 KOS18358.1 - 1.4e-86 290.5 0.1 1.1e-85 287.5 0.0 2.6 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 KOS18358.1 - 2.7e-36 124.7 7.2 2.6e-14 51.9 0.2 3.8 2 1 1 3 3 3 3 Cell morphogenesis central region HEAT_2 PF13646.6 KOS18358.1 - 0.003 17.9 0.6 3.5 8.1 0.0 5.0 6 0 0 6 6 6 1 HEAT repeats HEAT_EZ PF13513.6 KOS18358.1 - 0.014 15.9 0.3 0.53 10.9 0.0 3.5 2 0 0 2 2 2 0 HEAT-like repeat HEAT PF02985.22 KOS18358.1 - 0.031 14.5 0.1 0.86 10.0 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat FAD_binding_1 PF00667.20 KOS18359.1 - 3e-59 200.3 0.0 4.5e-59 199.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 KOS18359.1 - 7.6e-33 113.7 1.3 2e-32 112.3 1.3 1.8 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KOS18359.1 - 6.8e-20 71.7 0.0 3.9e-19 69.3 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Flavodoxin_5 PF12724.7 KOS18359.1 - 0.14 12.4 0.0 0.47 10.7 0.0 1.9 2 0 0 2 2 2 0 Flavodoxin domain Med5 PF08689.10 KOS18361.1 - 4.2e-53 180.5 0.0 4.5e-33 114.2 0.0 3.5 1 1 1 2 2 2 2 Mediator complex subunit Med5 adh_short PF00106.25 KOS18362.1 - 1.4e-21 76.8 0.0 5.8e-19 68.3 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS18362.1 - 1.1e-11 44.8 0.0 1.7e-09 37.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS18362.1 - 2.8e-07 30.6 0.1 4.8e-07 29.9 0.1 1.3 1 0 0 1 1 1 1 KR domain BetR PF08667.10 KOS18362.1 - 0.035 14.1 0.0 0.065 13.3 0.0 1.3 1 0 0 1 1 1 0 BetR domain ubiquitin PF00240.23 KOS18363.1 - 6.2e-18 64.3 0.1 9e-18 63.8 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family UBA PF00627.31 KOS18363.1 - 1.2e-06 28.3 0.1 1.2e-06 28.3 0.1 2.5 3 0 0 3 3 3 1 UBA/TS-N domain Rad60-SLD PF11976.8 KOS18363.1 - 1.9e-05 24.4 0.1 3.3e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 KOS18363.1 - 0.00044 20.8 0.1 0.00091 19.8 0.1 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 KOS18363.1 - 0.00067 19.7 0.1 0.0012 18.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like STI1 PF17830.1 KOS18363.1 - 0.0062 16.4 14.9 0.099 12.6 1.3 3.0 3 0 0 3 3 3 2 STI1 domain HOIP-UBA PF16678.5 KOS18363.1 - 0.025 14.6 0.0 0.05 13.6 0.0 1.5 1 0 0 1 1 1 0 HOIP UBA domain pair Ubiquitin_4 PF18036.1 KOS18363.1 - 0.17 11.9 0.5 13 5.9 0.1 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain GerD PF17898.1 KOS18363.1 - 0.34 10.9 3.4 0.74 9.8 3.4 1.5 1 1 0 1 1 1 0 Spore germination GerD central core domain Helicase_C PF00271.31 KOS18364.1 - 0.0025 18.1 0.0 0.0043 17.4 0.0 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Myb_DNA-binding PF00249.31 KOS18365.1 - 0.00056 20.1 0.9 0.0018 18.4 0.9 1.8 1 1 0 1 1 1 1 Myb-like DNA-binding domain Sigma70_r4_2 PF08281.12 KOS18365.1 - 0.01 15.5 0.1 0.1 12.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Sigma70_r4 PF04545.16 KOS18365.1 - 0.064 12.8 0.0 0.22 11.1 0.0 1.9 1 0 0 1 1 1 0 Sigma-70, region 4 Sigma70_ECF PF07638.11 KOS18365.1 - 0.1 12.4 1.5 0.19 11.6 0.1 2.1 3 0 0 3 3 3 0 ECF sigma factor HTH_23 PF13384.6 KOS18365.1 - 0.13 12.1 0.7 0.54 10.1 0.7 2.1 1 1 0 1 1 1 0 Homeodomain-like domain Glyco_hydro_76 PF03663.14 KOS18366.1 - 4.2e-38 131.8 4.0 4.2e-38 131.8 4.0 2.0 2 0 0 2 2 2 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOS18366.1 - 5.1e-08 32.4 0.8 0.0097 15.0 0.0 3.6 2 1 2 4 4 4 3 Glycosyl Hydrolase Family 88 TFCD_C PF12612.8 KOS18367.1 - 2.3e-20 73.3 0.0 1.3e-19 70.8 0.0 2.5 2 0 0 2 2 2 1 Tubulin folding cofactor D C terminal HEAT_2 PF13646.6 KOS18367.1 - 0.006 16.9 8.5 0.17 12.3 0.1 5.3 4 1 0 4 4 4 1 HEAT repeats HEAT PF02985.22 KOS18367.1 - 0.13 12.6 12.6 1.2 9.6 0.0 6.3 7 0 0 7 7 7 0 HEAT repeat Iso_dh PF00180.20 KOS18368.1 - 7.9e-97 324.5 0.0 3.6e-96 322.3 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase E3_UFM1_ligase PF09743.9 KOS18368.1 - 0.19 11.3 0.0 0.33 10.5 0.0 1.3 1 0 0 1 1 1 0 E3 UFM1-protein ligase 1 SH3_9 PF14604.6 KOS18369.1 - 4.1e-11 42.6 0.8 7.9e-08 32.0 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain DUF3741 PF12552.8 KOS18369.1 - 0.11 12.5 0.7 0.24 11.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3741) GATase PF00117.28 KOS18371.1 - 2.8e-14 53.4 0.0 3.8e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 KOS18371.1 - 0.0023 17.6 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 KOS18371.1 - 0.0036 17.1 0.1 0.01 15.6 0.1 1.9 1 1 0 1 1 1 1 Peptidase C26 Ribosomal_S4e PF00900.20 KOS18372.1 - 6.7e-37 125.2 0.1 1.9e-36 123.8 0.1 1.8 1 0 0 1 1 1 1 Ribosomal family S4e 40S_S4_C PF16121.5 KOS18372.1 - 2.6e-24 84.6 0.1 4.5e-24 83.8 0.1 1.4 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 KOS18372.1 - 6e-18 64.7 4.4 1.1e-17 63.8 4.4 1.5 1 0 0 1 1 1 1 RS4NT (NUC023) domain KOW PF00467.29 KOS18372.1 - 1.7e-05 24.6 2.6 1.7e-05 24.6 2.6 3.1 4 0 0 4 4 4 1 KOW motif S4 PF01479.25 KOS18372.1 - 8.5e-05 22.2 0.0 0.00016 21.3 0.0 1.5 1 0 0 1 1 1 1 S4 domain SH3_18 PF18354.1 KOS18372.1 - 0.13 12.3 0.1 3 8.0 0.0 2.5 2 1 0 2 2 2 0 CarS bacterial SH3 domain Sipho_tail PF05709.11 KOS18372.1 - 0.13 11.6 0.1 0.22 10.9 0.1 1.3 1 0 0 1 1 1 0 Phage tail protein Cu-oxidase PF00394.22 KOS18373.1 - 2.6e-24 86.2 0.0 4.3e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 KOS18373.1 - 2e-19 69.7 0.4 1.1e-16 60.8 0.0 3.1 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOS18373.1 - 1.1e-16 60.9 2.2 9.1e-15 54.7 0.4 3.3 3 1 0 3 3 3 1 Multicopper oxidase Myb_DNA-binding PF00249.31 KOS18375.1 - 5.5e-15 55.3 0.3 1.7e-08 34.5 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS18375.1 - 2.5e-09 37.2 0.1 0.00054 20.2 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 KOS18375.1 - 2.8e-07 30.6 1.4 0.031 14.3 0.0 2.9 3 1 0 3 3 3 2 SLIDE SUIM_assoc PF16619.5 KOS18375.1 - 0.056 13.5 3.3 0.22 11.6 3.3 2.2 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SANT_DAMP1_like PF16282.5 KOS18375.1 - 0.063 13.5 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 DUF4824 PF16106.5 KOS18375.1 - 0.07 12.4 0.6 0.11 11.7 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4824) Ebp2 PF05890.12 KOS18376.1 - 6.8e-98 327.5 10.4 6.8e-98 327.5 10.4 2.2 2 0 0 2 2 2 1 Eukaryotic rRNA processing protein EBP2 SLAC1 PF03595.17 KOS18377.1 - 2.7e-81 273.4 52.1 3.1e-81 273.1 52.1 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel CDO_I PF05995.12 KOS18378.1 - 2.2e-30 105.2 0.0 3.4e-30 104.6 0.0 1.2 1 0 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 KOS18378.1 - 0.017 14.5 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 PCO_ADO DinB PF05163.12 KOS18378.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 DinB family Metallophos PF00149.28 KOS18379.1 - 2.2e-38 132.8 0.5 3.9e-38 132.0 0.5 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase RXT2_N PF08595.11 KOS18379.1 - 0.023 14.8 1.0 0.036 14.1 1.0 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal WRNPLPNID PF15017.6 KOS18379.1 - 0.69 10.8 2.6 1.4 9.9 2.6 1.4 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Eapp_C PF10238.9 KOS18379.1 - 1.7 8.7 5.2 3.8 7.6 2.6 2.0 2 0 0 2 2 2 0 E2F-associated phosphoprotein Exo84_C PF16528.5 KOS18380.1 - 3.7e-77 258.8 0.2 3.7e-77 258.8 0.2 2.3 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 KOS18380.1 - 3e-13 49.7 2.3 3e-13 49.7 2.3 2.3 2 0 0 2 2 2 1 Vps51/Vps67 TSC22 PF01166.18 KOS18380.1 - 0.017 15.4 1.2 3 8.2 0.1 3.2 2 0 0 2 2 2 0 TSC-22/dip/bun family GldM_N PF12081.8 KOS18380.1 - 0.21 11.7 3.8 0.13 12.3 1.3 1.9 2 0 0 2 2 2 0 GldM N-terminal domain DUF2205 PF10224.9 KOS18380.1 - 0.24 11.4 2.7 1 9.4 2.7 2.1 1 0 0 1 1 1 0 Short coiled-coil protein DUF4618 PF15397.6 KOS18380.1 - 0.46 9.9 7.9 0.04 13.3 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) APG6_N PF17675.1 KOS18380.1 - 1.1 9.8 20.0 0.22 12.0 6.1 3.0 3 0 0 3 3 3 0 Apg6 coiled-coil region SH3_9 PF14604.6 KOS18381.1 - 6.9e-05 22.6 0.2 0.00013 21.7 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain Syndecan PF01034.20 KOS18381.1 - 0.0008 19.3 0.5 0.0014 18.5 0.5 1.3 1 0 0 1 1 1 1 Syndecan domain SH3_1 PF00018.28 KOS18381.1 - 0.00092 18.8 0.5 0.0091 15.6 0.2 2.3 2 0 0 2 2 2 1 SH3 domain CYYR1 PF10873.8 KOS18381.1 - 0.0037 17.7 0.9 0.0037 17.7 0.9 2.1 2 1 0 2 2 2 1 Cysteine and tyrosine-rich protein 1 Glycophorin_A PF01102.18 KOS18381.1 - 0.0048 17.1 0.0 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 Glycophorin A CbiM PF01891.16 KOS18381.1 - 0.01 15.7 0.5 0.015 15.1 0.5 1.1 1 0 0 1 1 1 0 Cobalt uptake substrate-specific transmembrane region TraL PF07178.11 KOS18381.1 - 0.042 14.3 0.5 0.075 13.5 0.5 1.3 1 0 0 1 1 1 0 TraL protein Orf78 PF06024.12 KOS18381.1 - 0.088 13.1 0.0 0.15 12.3 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) EphA2_TM PF14575.6 KOS18381.1 - 0.1 13.5 0.0 0.26 12.2 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mid2 PF04478.12 KOS18381.1 - 0.17 11.7 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF3112 PF11309.8 KOS18382.1 - 1.1e-07 31.5 6.9 2.1e-07 30.7 0.0 2.5 2 1 1 3 3 3 2 Protein of unknown function (DUF3112) GILT PF03227.16 KOS18383.1 - 3.4e-18 65.8 0.0 5.3e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) MFS_1 PF07690.16 KOS18384.1 - 2.2e-22 79.5 29.9 4e-16 58.9 15.4 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS18384.1 - 0.0039 16.1 4.8 0.0039 16.1 4.8 2.9 3 0 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 KOS18384.1 - 0.092 11.0 0.7 0.32 9.2 0.4 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Myb_Cef PF11831.8 KOS18385.1 - 4.8e-50 170.4 5.4 4.8e-50 170.4 5.4 2.9 3 0 0 3 3 3 1 pre-mRNA splicing factor component Myb_DNA-binding PF00249.31 KOS18385.1 - 1.3e-22 79.7 4.8 8.6e-11 41.9 0.9 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS18385.1 - 8.1e-21 74.0 7.7 8.4e-15 54.8 2.9 2.7 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 KOS18385.1 - 0.11 12.6 0.0 0.11 12.6 0.0 3.3 3 0 0 3 3 3 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MAS20 PF02064.15 KOS18386.1 - 1.2e-40 138.5 0.3 1.4e-40 138.3 0.3 1.0 1 0 0 1 1 1 1 MAS20 protein import receptor DUF2681 PF10883.8 KOS18386.1 - 0.006 17.0 0.3 0.0082 16.5 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2681) DUF5034 PF16437.5 KOS18386.1 - 0.17 11.8 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5034) SNF2_N PF00176.23 KOS18387.1 - 1.6e-48 165.2 0.3 3.6e-24 85.1 0.0 2.2 1 1 1 2 2 2 2 SNF2 family N-terminal domain Radical_SAM PF04055.21 KOS18387.1 - 7.2e-26 91.5 0.0 4.1e-24 85.8 0.0 2.9 2 1 0 2 2 2 1 Radical SAM superfamily Wyosine_form PF08608.12 KOS18387.1 - 1.3e-24 86.3 0.0 2.7e-24 85.3 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Helicase_C PF00271.31 KOS18387.1 - 3.5e-10 40.2 0.0 1.5e-09 38.2 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Flavodoxin_1 PF00258.25 KOS18387.1 - 3.9e-09 36.8 0.5 2.9e-07 30.8 0.5 2.9 1 1 0 1 1 1 1 Flavodoxin RPAP3_C PF13877.6 KOS18387.1 - 0.1 13.1 0.2 0.25 11.9 0.2 1.6 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 NUDIX PF00293.28 KOS18388.1 - 1.3e-08 34.9 0.1 5.5e-08 32.9 0.1 2.1 1 1 0 1 1 1 1 NUDIX domain Anillin PF08174.11 KOS18388.1 - 0.17 12.3 0.0 0.29 11.6 0.0 1.4 1 0 0 1 1 1 0 Cell division protein anillin Pheromone PF08015.11 KOS18388.1 - 6.2 7.9 13.7 0.31 12.1 5.3 2.8 2 0 0 2 2 2 0 Fungal mating-type pheromone Pkinase PF00069.25 KOS18389.1 - 8.4e-47 159.7 0.0 1.2e-46 159.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18389.1 - 1.4e-23 83.6 0.0 2.1e-23 82.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS18389.1 - 0.0001 22.3 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOS18389.1 - 0.0013 18.3 0.3 0.0041 16.7 0.3 1.7 1 1 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 KOS18389.1 - 0.31 10.6 1.8 0.23 11.0 0.2 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase Na_Ca_ex PF01699.24 KOS18390.1 - 4.5e-40 137.1 39.7 1.6e-20 73.6 12.5 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein CD225 PF04505.12 KOS18390.1 - 0.081 13.1 1.2 3.4 7.9 0.1 3.4 2 0 0 2 2 2 0 Interferon-induced transmembrane protein SWIRM-assoc_3 PF16498.5 KOS18390.1 - 0.1 12.9 3.2 0.32 11.3 3.2 1.8 1 0 0 1 1 1 0 SWIRM-associated domain at the C-terminal Pkinase PF00069.25 KOS18391.1 - 3.3e-63 213.5 0.0 6.1e-63 212.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18391.1 - 3.6e-36 124.8 0.0 1.2e-30 106.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOS18391.1 - 7.8e-07 28.7 0.0 0.0014 18.0 0.0 2.2 1 1 1 2 2 2 2 Kinase-like APH PF01636.23 KOS18391.1 - 0.0046 16.9 0.7 0.0069 16.3 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS18391.1 - 0.02 13.9 0.1 0.033 13.1 0.1 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 KOS18391.1 - 0.053 12.9 0.0 0.098 12.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOS18391.1 - 0.23 11.0 0.0 0.46 10.0 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pescadillo_N PF06732.11 KOS18392.1 - 1.8e-121 404.9 0.0 1.8e-121 404.9 0.0 1.5 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT PF00533.26 KOS18392.1 - 0.00012 22.4 0.0 0.00057 20.2 0.0 2.2 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Astro_capsid_p PF12226.8 KOS18392.1 - 0.0045 16.2 16.9 0.0045 16.2 16.9 1.7 2 0 0 2 2 2 1 Turkey astrovirus capsid protein CDC45 PF02724.14 KOS18392.1 - 5.4 5.2 29.1 9.9 4.3 29.1 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 KOS18392.1 - 7.4 5.8 36.7 0.039 13.3 27.4 1.8 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) RRN9 PF10680.9 KOS18393.1 - 2.7e-16 59.6 0.3 1.1e-15 57.7 0.3 2.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor zf-C2H2 PF00096.26 KOS18393.1 - 0.022 15.2 1.8 0.06 13.8 1.8 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 KOS18393.1 - 0.075 12.8 0.7 0.19 11.5 0.7 1.7 1 0 0 1 1 1 0 C2H2-type zinc-finger domain PPP4R2 PF09184.11 KOS18394.1 - 4.8e-08 32.9 7.5 5.4e-07 29.5 0.0 2.4 3 0 0 3 3 3 1 PPP4R2 SUIM_assoc PF16619.5 KOS18394.1 - 5.4 7.2 12.5 0.15 12.1 4.5 2.5 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 SPRY PF00622.28 KOS18395.1 - 9e-06 25.8 0.0 1.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 SPRY domain COesterase PF00135.28 KOS18396.1 - 3.7e-47 161.4 0.0 4.2e-47 161.2 0.0 1.0 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOS18396.1 - 0.0012 18.8 0.2 0.015 15.2 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold FAD_binding_3 PF01494.19 KOS18397.1 - 9.9e-30 103.9 0.2 1.4e-14 54.2 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 KOS18397.1 - 0.00038 19.8 0.1 0.029 13.6 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS18397.1 - 0.0079 16.4 0.0 0.025 14.8 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOS18397.1 - 0.0089 15.4 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 KOS18397.1 - 0.021 14.0 0.3 1.8 7.7 0.1 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOS18397.1 - 0.025 13.7 2.0 1.8 7.5 0.1 2.9 3 0 0 3 3 3 0 Lycopene cyclase protein Pyr_redox PF00070.27 KOS18397.1 - 0.049 14.2 1.0 1.7 9.3 0.3 2.5 2 1 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 KOS18397.1 - 0.061 13.8 0.2 0.19 12.2 0.1 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Thi4 PF01946.17 KOS18397.1 - 0.1 11.8 0.2 0.1 11.8 0.2 1.6 2 0 0 2 2 2 0 Thi4 family Trp_halogenase PF04820.14 KOS18397.1 - 0.44 9.4 3.5 9.1 5.0 0.7 2.8 3 0 0 3 3 3 0 Tryptophan halogenase Tom37 PF10568.9 KOS18398.1 - 1.3e-32 112.7 0.3 2.3e-32 111.9 0.3 1.4 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_N_4 PF17172.4 KOS18398.1 - 1e-08 35.8 0.0 5.4e-08 33.5 0.0 2.2 3 0 0 3 3 3 1 Glutathione S-transferase N-terminal domain GST_C_6 PF17171.4 KOS18398.1 - 4.3e-06 26.4 0.2 2e-05 24.3 0.0 2.2 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain PIG-U PF06728.13 KOS18399.1 - 1.3e-118 396.4 20.1 1.4e-118 396.3 20.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Mannosyl_trans PF05007.13 KOS18399.1 - 0.00039 20.4 2.6 0.00047 20.1 0.0 2.0 1 1 1 2 2 2 1 Mannosyltransferase (PIG-M) RRM_1 PF00076.22 KOS18400.1 - 2e-59 197.3 0.0 1.6e-21 75.9 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS18400.1 - 1.5e-10 40.7 0.0 7.7e-06 25.5 0.0 3.2 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS18400.1 - 2.5e-09 36.9 0.0 0.0091 15.8 0.0 3.3 3 0 0 3 3 3 2 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KOS18400.1 - 1.1e-06 28.6 0.0 0.2 11.7 0.0 3.4 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KOS18400.1 - 0.0013 18.8 0.1 1 9.5 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif RRM_8 PF11835.8 KOS18400.1 - 0.0014 18.7 0.0 0.28 11.4 0.0 2.5 2 0 0 2 2 2 1 RRM-like domain Cas_Cas2CT1978 PF09707.10 KOS18400.1 - 0.0032 17.5 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 2 CRISPR-associated protein (Cas_Cas2CT1978) BRAP2 PF07576.12 KOS18400.1 - 0.18 12.0 0.1 0.84 9.9 0.0 2.0 2 0 0 2 2 2 0 BRCA1-associated protein 2 SPX PF03105.19 KOS18401.1 - 0.013 15.5 6.8 0.013 15.4 6.8 1.1 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 KOS18401.1 - 0.025 13.5 6.6 0.026 13.4 6.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 KOS18401.1 - 0.04 12.5 6.7 0.046 12.3 6.7 1.1 1 0 0 1 1 1 0 Macoilin family SR-25 PF10500.9 KOS18401.1 - 0.11 12.1 15.4 0.21 11.2 15.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2062 PF09835.9 KOS18401.1 - 0.11 12.3 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2062) Presenilin PF01080.17 KOS18401.1 - 0.24 10.1 2.1 0.34 9.6 2.1 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KOS18401.1 - 0.79 7.9 3.8 1 7.6 3.8 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 KOS18401.1 - 8.6 5.0 10.2 3.4 6.3 8.0 1.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Pkinase PF00069.25 KOS18402.1 - 2.9e-62 210.4 0.0 4.9e-62 209.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18402.1 - 4.3e-28 98.3 0.0 7.6e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOS18402.1 - 5e-05 22.8 0.0 8.7e-05 22.0 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS18402.1 - 0.0035 16.7 0.0 0.0058 16.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOS18402.1 - 0.0079 15.2 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOS18402.1 - 0.039 13.9 0.2 0.039 13.9 0.2 2.6 2 1 0 2 2 2 0 Phosphotransferase enzyme family rRNA_processing PF08524.11 KOS18402.1 - 0.34 10.9 12.4 0.6 10.1 12.4 1.3 1 0 0 1 1 1 0 rRNA processing Cwf_Cwc_15 PF04889.12 KOS18402.1 - 0.48 10.1 16.7 1.1 9.0 16.7 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4662 PF15578.6 KOS18402.1 - 2 8.1 5.6 3 7.6 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) PPR_2 PF13041.6 KOS18403.1 - 9.1e-21 73.8 0.0 9.8e-16 57.7 0.0 3.1 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 KOS18403.1 - 1.2e-07 31.7 0.0 0.00041 20.4 0.0 2.7 2 0 0 2 2 2 2 Pentatricopeptide repeat domain PPR PF01535.20 KOS18403.1 - 2.8e-05 24.1 2.2 0.011 16.0 0.0 4.6 5 0 0 5 5 5 1 PPR repeat PPR_long PF17177.4 KOS18403.1 - 0.00012 21.5 0.1 0.00025 20.5 0.1 1.5 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP Chromate_transp PF02417.15 KOS18403.1 - 0.047 13.8 1.3 0.11 12.7 1.3 1.5 1 1 0 1 1 1 0 Chromate transporter betaPIX_CC PF16523.5 KOS18403.1 - 0.061 13.2 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 betaPIX coiled coil PPR_1 PF12854.7 KOS18403.1 - 0.07 12.8 4.7 19 5.0 0.0 4.4 4 0 0 4 4 4 0 PPR repeat TPR_1 PF00515.28 KOS18405.1 - 1.5e-31 106.9 21.3 1.6e-05 24.5 0.3 11.6 12 0 0 12 12 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18405.1 - 8e-30 100.5 26.7 0.00054 19.9 0.2 12.4 12 0 0 12 12 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 KOS18405.1 - 3e-22 76.9 12.5 0.0011 19.0 0.3 10.9 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOS18405.1 - 4.3e-18 65.4 17.3 3.7e-05 23.9 0.4 9.9 9 1 2 12 12 10 6 Tetratricopeptide repeat TPR_14 PF13428.6 KOS18405.1 - 1.9e-15 56.2 27.0 0.01 16.6 0.2 13.1 12 3 3 15 15 14 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOS18405.1 - 2.2e-14 52.3 12.2 0.0055 16.6 0.0 10.0 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_19 PF14559.6 KOS18405.1 - 7e-13 48.9 23.5 0.00067 20.1 0.1 10.2 8 3 4 12 12 12 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOS18405.1 - 3.9e-11 42.4 19.1 0.3 10.8 0.0 8.9 10 0 0 10 10 9 4 TPR repeat TPR_10 PF13374.6 KOS18405.1 - 5.5e-10 38.8 9.4 0.21 11.5 0.0 9.3 10 0 0 10 10 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOS18405.1 - 1.3e-09 38.1 13.7 0.18 12.5 0.0 9.9 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS18405.1 - 2.8e-09 36.7 11.0 1.5 9.3 0.0 10.5 12 0 0 12 12 11 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18405.1 - 2e-06 28.4 37.9 0.013 16.2 0.4 9.5 11 1 1 12 12 10 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS18405.1 - 0.00036 20.7 14.7 0.13 12.5 0.9 6.8 8 0 0 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 KOS18405.1 - 2.3 8.3 11.6 26 4.9 0.1 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat FAD_binding_6 PF00970.24 KOS18406.1 - 3.5e-30 104.3 0.0 6.3e-30 103.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 KOS18406.1 - 8.3e-28 97.2 0.0 1.2e-27 96.7 0.0 1.2 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 KOS18406.1 - 3.9e-05 23.8 0.0 0.004 17.3 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain FAD_binding_9 PF08021.11 KOS18406.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain GATase_4 PF13230.6 KOS18407.1 - 6.5e-14 51.5 0.0 1.6e-13 50.2 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II GATase_6 PF13522.6 KOS18407.1 - 9.1e-09 35.6 0.0 1.9e-08 34.6 0.0 1.5 2 0 0 2 2 2 1 Glutamine amidotransferase domain zf-NOSIP PF15906.5 KOS18408.1 - 5.6e-05 23.2 0.0 0.00012 22.1 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-RING_UBOX PF13445.6 KOS18408.1 - 5.7e-05 23.1 11.5 0.00016 21.7 2.1 2.8 2 1 0 2 2 2 2 RING-type zinc-finger zf-RING_5 PF14634.6 KOS18408.1 - 7e-05 22.7 3.1 7e-05 22.7 3.1 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOS18408.1 - 0.0007 19.7 13.2 0.004 17.3 2.9 2.8 2 1 0 2 2 2 2 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 KOS18408.1 - 0.0026 17.6 4.1 0.0026 17.6 4.1 2.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS18408.1 - 0.0027 18.0 16.4 0.11 12.9 6.1 3.0 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 KOS18408.1 - 0.0057 16.5 1.6 0.0057 16.5 1.6 3.0 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_5 PF17121.5 KOS18408.1 - 0.063 13.2 1.8 0.16 11.9 1.8 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 KOS18408.1 - 0.17 12.1 11.6 0.49 10.6 3.2 3.2 2 1 1 3 3 3 0 FYVE zinc finger zf-RING_10 PF16685.5 KOS18408.1 - 1.5 9.0 10.5 0.21 11.8 2.7 2.7 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-RING_6 PF14835.6 KOS18408.1 - 7.7 6.5 13.4 6.9 6.6 3.1 2.9 3 0 0 3 3 3 0 zf-RING of BARD1-type protein mRNA_cap_enzyme PF01331.19 KOS18409.1 - 5e-55 186.4 0.1 6.7e-55 185.9 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 KOS18409.1 - 1.4e-30 106.1 0.0 2.5e-30 105.3 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 KOS18409.1 - 5.7e-09 35.9 0.0 1.8e-05 24.5 0.0 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain RNA_ligase PF09414.10 KOS18409.1 - 0.00015 22.1 0.0 0.00023 21.5 0.0 1.3 1 0 0 1 1 1 1 RNA ligase PX PF00787.24 KOS18410.1 - 5.9e-19 68.1 0.0 2.2e-18 66.3 0.0 1.9 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 KOS18410.1 - 7.2e-12 45.4 7.8 1.1e-06 28.4 0.1 2.1 2 0 0 2 2 2 2 Vps5 C terminal like NMT1 PF09084.11 KOS18411.1 - 5.1e-05 23.3 0.0 0.054 13.4 0.0 2.3 2 1 0 2 2 2 2 NMT1/THI5 like Phosphonate-bd PF12974.7 KOS18411.1 - 0.0005 19.7 0.0 0.0012 18.5 0.0 1.4 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 KOS18411.1 - 0.017 14.6 0.0 0.11 11.9 0.0 2.0 1 1 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 SBP_bac_11 PF13531.6 KOS18411.1 - 0.057 13.2 0.0 0.72 9.6 0.0 2.2 2 1 1 3 3 3 0 Bacterial extracellular solute-binding protein NMT1_3 PF16868.5 KOS18411.1 - 0.065 12.6 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family NAPRTase_N PF17767.1 KOS18411.1 - 0.13 12.7 0.0 0.19 12.1 0.0 1.2 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain EamA PF00892.20 KOS18412.1 - 4.3e-09 36.7 26.7 4.7e-05 23.6 0.3 3.0 3 0 0 3 3 3 2 EamA-like transporter family DUF3955 PF13127.6 KOS18412.1 - 0.00027 20.7 0.7 0.00027 20.7 0.7 3.1 4 0 0 4 4 4 1 Protein of unknown function (DUF3955) UAA PF08449.11 KOS18412.1 - 0.00067 18.9 7.3 0.0012 18.1 7.3 1.4 1 0 0 1 1 1 1 UAA transporter family EmrE PF13536.6 KOS18412.1 - 0.0027 17.4 7.5 0.0045 16.6 7.5 1.4 1 0 0 1 1 1 1 Putative multidrug resistance efflux transporter Heme_oxygenase PF01126.20 KOS18413.1 - 5.1e-10 39.5 0.0 8e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Heme oxygenase WD40 PF00400.32 KOS18414.1 - 1.8e-10 41.2 8.8 0.00035 21.3 0.1 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18414.1 - 3.1e-06 27.4 0.1 0.69 10.2 0.0 4.6 3 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 KOS18415.1 - 1.9e-77 260.2 0.0 2.2e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18415.1 - 6.4e-38 130.5 0.0 8.3e-38 130.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS18415.1 - 0.0029 16.6 0.0 0.033 13.1 0.0 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 KOS18415.1 - 0.05 13.5 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 KOS18415.1 - 0.094 12.1 0.0 0.16 11.3 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Methyltransf_28 PF02636.17 KOS18416.1 - 3.3e-79 266.2 0.0 3.9e-79 266.0 0.0 1.0 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Acyltransferase PF01553.21 KOS18417.1 - 2.9e-14 52.8 0.0 4.3e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Atrophin-1 PF03154.15 KOS18418.1 - 0.073 11.4 6.7 0.085 11.1 6.7 1.0 1 0 0 1 1 1 0 Atrophin-1 family SAP25 PF15476.6 KOS18418.1 - 0.18 11.5 9.8 0.17 11.5 9.3 1.3 1 1 0 1 1 1 0 Histone deacetylase complex subunit SAP25 Macoilin PF09726.9 KOS18418.1 - 0.59 8.6 3.3 0.64 8.5 3.3 1.0 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 KOS18418.1 - 3.7 5.5 11.1 3.8 5.5 11.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RAP1 PF07218.11 KOS18418.1 - 4.6 5.4 10.7 4.8 5.3 10.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Herpes_capsid PF06112.11 KOS18418.1 - 6.6 6.8 17.5 8.1 6.5 17.5 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein FAM199X PF15814.5 KOS18418.1 - 8.6 5.3 14.6 10 5.0 14.6 1.1 1 0 0 1 1 1 0 Protein family FAM199X AAA PF00004.29 KOS18419.1 - 2e-98 325.9 0.0 9.8e-48 161.9 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS18419.1 - 1.3e-23 82.5 6.7 4.5e-12 45.6 0.9 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 KOS18419.1 - 3e-18 65.8 0.3 1.2e-17 63.9 0.3 2.1 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 KOS18419.1 - 1.4e-14 54.1 0.0 3.2e-06 27.0 0.0 3.4 4 1 0 4 4 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOS18419.1 - 7.3e-14 52.2 0.0 2.1e-07 31.2 0.0 2.8 2 1 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 KOS18419.1 - 2.2e-13 50.9 0.0 0.00017 22.0 0.0 4.5 3 2 1 4 4 3 2 AAA ATPase domain AAA_5 PF07728.14 KOS18419.1 - 3.4e-12 46.5 0.4 3.4e-06 27.1 0.1 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOS18419.1 - 5e-12 46.2 0.0 4.1e-05 23.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOS18419.1 - 2e-09 37.9 0.3 0.028 14.7 0.0 4.0 2 2 2 4 4 3 2 AAA domain TIP49 PF06068.13 KOS18419.1 - 3.2e-09 36.5 0.1 0.0011 18.2 0.0 2.7 2 1 0 2 2 2 2 TIP49 P-loop domain CDC48_2 PF02933.17 KOS18419.1 - 2.7e-08 33.5 0.3 4.1e-07 29.7 0.0 2.5 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_25 PF13481.6 KOS18419.1 - 1.9e-07 30.9 2.0 0.11 12.0 0.0 4.0 2 2 1 4 4 4 3 AAA domain Mg_chelatase PF01078.21 KOS18419.1 - 2.1e-07 30.6 0.2 0.0069 15.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 KOS18419.1 - 2.2e-07 31.5 0.0 0.027 15.0 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 KOS18419.1 - 2.8e-07 30.4 0.1 0.019 14.7 0.0 2.9 3 0 0 3 3 2 2 IstB-like ATP binding protein Vps4_C PF09336.10 KOS18419.1 - 4.8e-07 29.7 0.1 7.5e-06 25.9 0.0 2.5 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain ATPase PF06745.13 KOS18419.1 - 5.1e-07 29.3 0.2 0.25 10.7 0.0 3.5 3 0 0 3 3 3 2 KaiC AAA_14 PF13173.6 KOS18419.1 - 5.5e-07 29.7 0.0 0.008 16.2 0.0 2.8 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 KOS18419.1 - 6.5e-07 29.7 0.0 0.036 14.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase AAA_7 PF12775.7 KOS18419.1 - 3e-06 26.9 0.1 0.045 13.3 0.0 2.9 2 2 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 KOS18419.1 - 5.7e-06 26.2 0.0 0.083 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_28 PF13521.6 KOS18419.1 - 8.5e-06 26.1 0.1 0.15 12.3 0.0 3.0 3 0 0 3 3 3 2 AAA domain Parvo_NS1 PF01057.17 KOS18419.1 - 9.2e-06 24.9 0.0 0.053 12.6 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 DUF815 PF05673.13 KOS18419.1 - 9.8e-06 24.9 0.0 0.019 14.1 0.0 2.6 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ABC_tran PF00005.27 KOS18419.1 - 1.2e-05 25.8 0.0 0.22 12.0 0.0 3.7 2 1 0 2 2 2 2 ABC transporter Bac_DnaA PF00308.18 KOS18419.1 - 1.7e-05 24.8 0.0 0.072 12.9 0.0 2.9 3 0 0 3 3 3 2 Bacterial dnaA protein Sigma54_activat PF00158.26 KOS18419.1 - 1.9e-05 24.4 0.1 0.23 11.1 0.0 3.3 2 2 0 2 2 2 2 Sigma-54 interaction domain TsaE PF02367.17 KOS18419.1 - 7.4e-05 22.7 0.0 0.46 10.5 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 KOS18419.1 - 0.00013 21.9 0.1 0.18 11.7 0.0 2.9 3 0 0 3 3 3 1 NACHT domain PhoH PF02562.16 KOS18419.1 - 0.00018 21.0 0.2 0.6 9.5 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ResIII PF04851.15 KOS18419.1 - 0.00019 21.5 0.0 0.047 13.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 KOS18419.1 - 0.00021 21.2 0.0 0.68 9.8 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 KOS18419.1 - 0.00021 21.7 0.0 0.59 10.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOS18419.1 - 0.00035 20.4 0.0 0.97 9.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOS18419.1 - 0.00038 20.2 0.4 1.2 8.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 KOS18419.1 - 0.0006 19.8 0.0 1.9 8.4 0.0 3.4 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KOS18419.1 - 0.001 19.4 0.5 5.4 7.3 0.0 3.7 3 1 1 4 4 3 0 AAA domain DUF2075 PF09848.9 KOS18419.1 - 0.0018 17.6 0.0 1.6 7.9 0.0 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 KOS18419.1 - 0.0034 17.5 0.0 0.51 10.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain NTPase_1 PF03266.15 KOS18419.1 - 0.0042 17.0 0.5 2.5 8.0 0.0 4.0 4 0 0 4 4 3 1 NTPase NB-ARC PF00931.22 KOS18419.1 - 0.0047 16.2 0.0 1.6 7.9 0.0 2.5 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 KOS18419.1 - 0.0061 15.9 0.3 7.7 5.7 0.0 3.3 3 0 0 3 3 3 0 Zeta toxin Viral_helicase1 PF01443.18 KOS18419.1 - 0.0077 16.0 0.0 0.33 10.7 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase IPT PF01745.16 KOS18419.1 - 0.013 14.9 0.0 1.8 7.9 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase KAP_NTPase PF07693.14 KOS18419.1 - 0.021 14.1 0.4 0.86 8.8 0.0 3.1 2 2 1 4 4 4 0 KAP family P-loop domain Zot PF05707.12 KOS18419.1 - 0.037 13.7 0.0 2.3 7.8 0.0 3.2 3 1 0 3 3 3 0 Zonular occludens toxin (Zot) AAA_6 PF12774.7 KOS18419.1 - 0.052 12.5 0.3 7.6 5.4 0.0 2.5 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region Cytidylate_kin PF02224.18 KOS18419.1 - 0.057 13.2 0.0 10 5.8 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase AFG1_ATPase PF03969.16 KOS18419.1 - 0.062 12.2 0.0 8.5 5.1 0.0 2.4 2 0 0 2 2 2 0 AFG1-like ATPase TFIIS_M PF07500.14 KOS18420.1 - 3.4e-26 91.9 1.5 3.4e-26 91.9 1.5 1.8 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 KOS18420.1 - 1.8e-18 66.1 7.1 2.7e-18 65.5 7.1 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 KOS18420.1 - 1.7e-10 40.7 0.4 1.7e-10 40.7 0.4 2.5 3 0 0 3 3 3 1 TFIIS helical bundle-like domain XPG_N PF00752.17 KOS18421.1 - 3.2e-33 114.2 0.0 8.1e-33 112.9 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 KOS18421.1 - 1.7e-25 89.2 0.0 5.7e-25 87.5 0.0 2.0 1 0 0 1 1 1 1 XPG I-region UIM PF02809.20 KOS18421.1 - 0.0033 17.3 1.3 0.0033 17.3 1.3 3.7 2 0 0 2 2 2 1 Ubiquitin interaction motif 5_3_exonuc PF01367.20 KOS18421.1 - 0.022 15.3 0.1 0.072 13.7 0.0 1.9 2 0 0 2 2 2 0 5'-3' exonuclease, C-terminal SAM fold zf-met2 PF12907.7 KOS18422.1 - 4.5e-15 55.5 4.8 7.4e-15 54.8 4.8 1.4 1 0 0 1 1 1 1 Zinc-binding 4F5 PF04419.14 KOS18422.1 - 2.2e-08 34.8 11.0 3.5e-08 34.2 11.0 1.3 1 0 0 1 1 1 1 4F5 protein family DUF3496 PF12001.8 KOS18422.1 - 0.013 15.8 0.4 0.016 15.6 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) HypA PF01155.19 KOS18422.1 - 0.037 14.0 0.5 0.04 13.9 0.5 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF382 PF04037.13 KOS18422.1 - 0.079 13.1 0.3 0.096 12.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF382) zinc_ribbon_5 PF13719.6 KOS18422.1 - 0.24 11.2 2.5 3.7 7.4 0.6 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DIOX_N PF14226.6 KOS18423.1 - 4.1e-31 108.2 0.0 6.1e-31 107.6 0.0 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOS18423.1 - 7.5e-12 45.6 0.0 1.5e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pro_isomerase PF00160.21 KOS18424.1 - 8.9e-50 169.0 0.2 1e-49 168.9 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Ribosomal_S24e PF01282.19 KOS18424.1 - 0.096 12.7 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein S24e Pectate_lyase_3 PF12708.7 KOS18425.1 - 3.1e-40 138.3 7.7 9.2e-35 120.4 3.3 2.5 2 1 0 2 2 2 2 Pectate lyase superfamily protein NosD PF05048.13 KOS18425.1 - 0.0037 16.6 0.8 0.0037 16.6 0.8 2.5 2 1 0 2 2 2 1 Periplasmic copper-binding protein (NosD) Bap31 PF05529.12 KOS18426.1 - 1.1e-47 161.3 9.5 1.7e-47 160.6 9.5 1.4 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region EZH2_N PF18601.1 KOS18426.1 - 9.9e-39 131.6 1.9 2.4e-38 130.3 1.4 2.0 2 0 0 2 2 2 1 EZH2 N-terminal domain Ezh2_MCSS PF18600.1 KOS18426.1 - 1.8e-24 85.1 0.7 3.9e-24 84.0 0.7 1.6 1 0 0 1 1 1 1 MCSS domain SET PF00856.28 KOS18426.1 - 3.6e-16 60.0 0.1 3.6e-16 60.0 0.1 3.3 4 1 0 4 4 4 1 SET domain Bap31_Bap29_C PF18035.1 KOS18426.1 - 1.2e-11 44.4 10.5 8.4e-11 41.7 11.7 1.8 2 0 0 2 2 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain preSET_CXC PF18264.1 KOS18426.1 - 5.6e-06 26.7 14.1 5.6e-06 26.7 14.1 3.7 2 1 2 4 4 4 1 CXC domain RibD_C PF01872.17 KOS18427.1 - 0.023 14.5 0.0 0.04 13.7 0.0 1.3 1 0 0 1 1 1 0 RibD C-terminal domain HHH PF00633.23 KOS18427.1 - 0.1 12.5 0.4 0.26 11.2 0.4 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif LSM PF01423.22 KOS18428.1 - 5.5e-10 38.8 0.0 7.3e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS18428.1 - 0.013 15.6 0.0 0.019 15.1 0.0 1.4 1 1 0 1 1 1 0 Ataxin 2 SM domain Pil1 PF13805.6 KOS18429.1 - 8.7e-126 418.8 0.2 1.5e-125 418.1 0.1 1.4 1 1 0 1 1 1 1 Eisosome component PIL1 Gtr1_RagA PF04670.12 KOS18429.1 - 0.095 12.0 0.1 0.17 11.2 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Atg14 PF10186.9 KOS18429.1 - 0.57 9.2 4.8 4.4 6.3 0.2 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 KOS18429.1 - 9 6.8 9.9 19 5.8 2.9 2.9 1 1 2 3 3 3 0 Apg6 coiled-coil region zf-Tim10_DDP PF02953.15 KOS18431.1 - 5.3e-20 70.8 2.2 6.3e-20 70.6 2.2 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger bZIP_1 PF00170.21 KOS18431.1 - 0.078 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 bZIP transcription factor Pribosyltran PF00156.27 KOS18432.1 - 1.5e-15 57.0 0.0 2.5e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOS18432.1 - 0.0047 16.4 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CLTH PF10607.9 KOS18433.1 - 1.2e-29 103.1 0.0 2.1e-29 102.3 0.0 1.4 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 KOS18433.1 - 3.1e-08 33.5 5.7 6.6e-08 32.5 5.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS18433.1 - 4.3e-06 26.6 2.4 8.4e-06 25.6 2.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KOS18433.1 - 1.7e-05 25.0 3.1 3.5e-05 24.0 3.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOS18433.1 - 2.8e-05 23.9 4.9 6.8e-05 22.6 4.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS18433.1 - 6.5e-05 22.7 2.0 0.00013 21.8 2.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOS18433.1 - 7.7e-05 22.5 1.7 0.00015 21.6 1.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Rtf2 PF04641.12 KOS18433.1 - 8.3e-05 22.1 0.4 8.3e-05 22.1 0.4 1.8 2 0 0 2 2 2 1 Rtf2 RING-finger zf-C3HC4_2 PF13923.6 KOS18433.1 - 0.00053 19.8 3.8 0.0012 18.6 3.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BUD22 PF09073.10 KOS18433.1 - 0.003 17.0 13.0 0.0043 16.5 13.0 1.1 1 0 0 1 1 1 1 BUD22 zf-C3HC4_4 PF15227.6 KOS18433.1 - 0.0046 17.1 4.0 0.0098 16.0 4.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Mpp10 PF04006.12 KOS18433.1 - 0.056 11.9 11.9 0.071 11.6 11.9 1.1 1 0 0 1 1 1 0 Mpp10 protein VWA_2 PF13519.6 KOS18433.1 - 0.097 13.3 0.2 0.26 12.0 0.2 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain zf-RING_4 PF14570.6 KOS18433.1 - 0.1 12.4 2.5 0.22 11.3 2.5 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Matrilin_ccoil PF10393.9 KOS18433.1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.6 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin SDA1 PF05285.12 KOS18433.1 - 0.21 11.0 18.3 0.3 10.5 18.3 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS18433.1 - 2.1 6.5 13.0 3.9 5.6 13.0 1.4 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 KOS18433.1 - 2.9 6.6 7.3 3.7 6.2 7.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIA PF03153.13 KOS18433.1 - 9.5 6.1 19.0 13 5.6 19.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IFT57 PF10498.9 KOS18433.1 - 9.7 5.0 9.2 4.7 6.1 6.8 1.6 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 PG_binding_1 PF01471.18 KOS18434.1 - 0.0054 16.9 0.0 6.1 7.1 0.0 3.2 3 0 0 3 3 3 2 Putative peptidoglycan binding domain Menin PF05053.13 KOS18434.1 - 1.1 7.5 3.5 5.5 5.2 1.6 2.2 2 0 0 2 2 2 0 Menin MscS_TM PF12794.7 KOS18436.1 - 0.064 12.1 11.8 0.096 11.5 2.5 2.2 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 GATA PF00320.27 KOS18437.1 - 4.3e-16 58.2 5.4 9.2e-16 57.2 5.4 1.6 1 0 0 1 1 1 1 GATA zinc finger PAS_3 PF08447.12 KOS18437.1 - 5.8e-14 52.1 0.0 1.1e-13 51.2 0.0 1.4 1 0 0 1 1 1 1 PAS fold PAS PF00989.25 KOS18437.1 - 7.4e-07 29.2 0.0 2.2e-06 27.7 0.0 1.7 2 0 0 2 2 2 1 PAS fold PAS_4 PF08448.10 KOS18437.1 - 8.6e-06 26.0 0.0 2.9e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 KOS18437.1 - 0.00023 21.2 0.0 0.00045 20.3 0.0 1.4 1 0 0 1 1 1 1 PAS domain Zn-ribbon_8 PF09723.10 KOS18437.1 - 0.0095 16.0 0.2 0.019 15.1 0.2 1.4 1 0 0 1 1 1 1 Zinc ribbon domain PAS_9 PF13426.7 KOS18437.1 - 0.033 14.5 0.0 0.15 12.4 0.0 1.9 2 0 0 2 2 2 0 PAS domain TF_Zn_Ribbon PF08271.12 KOS18437.1 - 0.11 12.0 0.6 0.76 9.4 0.1 2.3 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4428 PF14471.6 KOS18437.1 - 3.4 7.7 5.2 1 9.3 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4428) Amidase PF01425.21 KOS18438.1 - 2.5e-53 181.7 0.0 4.6e-53 180.8 0.0 1.3 1 1 0 1 1 1 1 Amidase Glyco_hydro_47 PF01532.20 KOS18439.1 - 5.1e-111 371.8 0.0 1.4e-110 370.4 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 DUF2722 PF10846.8 KOS18439.1 - 0.00038 19.5 12.9 0.00061 18.9 12.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 KOS18439.1 - 0.023 14.7 14.7 0.037 14.0 14.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3464 PF11947.8 KOS18439.1 - 0.035 13.9 0.5 0.074 12.8 0.5 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 dsDNA_bind PF01984.20 KOS18439.1 - 0.11 12.8 14.1 0.21 11.9 14.1 1.3 1 0 0 1 1 1 0 Double-stranded DNA-binding domain RR_TM4-6 PF06459.12 KOS18439.1 - 0.16 11.8 5.3 9.7 5.9 4.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Spt20 PF12090.8 KOS18439.1 - 0.28 10.7 25.6 0.46 10.1 25.6 1.2 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 KOS18439.1 - 0.36 10.8 8.3 0.61 10.0 8.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF775 PF05603.12 KOS18439.1 - 0.54 9.8 4.6 0.89 9.1 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF775) SpoIIP PF07454.11 KOS18439.1 - 1.3 8.5 5.3 2 7.8 5.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 KOS18439.1 - 1.6 7.5 4.2 2.3 6.9 4.2 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 KOS18439.1 - 3.4 8.7 8.8 6.4 7.8 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pex14_N PF04695.13 KOS18439.1 - 5.1 7.7 15.0 0.059 14.0 4.8 2.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EIIBC-GUT_N PF03612.14 KOS18439.1 - 9.2 6.0 7.2 16 5.2 7.2 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Myb_DNA-bind_3 PF12776.7 KOS18440.1 - 0.097 13.7 1.5 0.14 13.1 0.6 1.7 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain AIP3 PF03915.13 KOS18441.1 - 1.4e-150 502.0 12.7 1.4e-150 502.0 12.7 1.9 2 0 0 2 2 2 1 Actin interacting protein 3 NPV_P10 PF05531.12 KOS18441.1 - 0.014 15.8 5.5 0.21 12.0 0.1 3.8 2 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 KOS18441.1 - 0.022 14.5 0.2 0.022 14.5 0.2 3.4 4 1 0 4 4 4 0 Hepatic lectin, N-terminal domain FliL PF03748.14 KOS18441.1 - 0.11 13.1 0.7 1.5 9.5 0.1 3.0 2 0 0 2 2 2 0 Flagellar basal body-associated protein FliL DUF1664 PF07889.12 KOS18441.1 - 0.15 12.1 0.1 0.15 12.1 0.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) Wtap PF17098.5 KOS18441.1 - 0.37 10.7 6.4 0.14 12.1 0.7 3.0 3 0 0 3 3 3 0 WTAP/Mum2p family SKA1 PF07160.12 KOS18441.1 - 5.8 6.7 18.8 0.77 9.6 0.7 4.0 4 2 1 5 5 5 0 Spindle and kinetochore-associated protein 1 PAPA-1 PF04795.12 KOS18442.1 - 4.2e-31 107.6 3.3 4.2e-31 107.6 3.3 5.3 3 2 0 3 3 3 1 PAPA-1-like conserved region MFS_1 PF07690.16 KOS18443.1 - 5.6e-20 71.6 43.4 5.6e-20 71.6 43.4 2.6 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS18443.1 - 4.3e-10 38.6 24.7 6.5e-10 38.1 24.7 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) LisH_2 PF16045.5 KOS18443.1 - 0.19 10.8 0.8 0.5 9.5 0.1 2.1 2 0 0 2 2 2 0 LisH TraQ PF09679.10 KOS18443.1 - 5 7.1 7.5 4.9 7.1 0.5 3.0 2 1 1 3 3 3 0 Type-F conjugative transfer system pilin chaperone (TraQ) Ras PF00071.22 KOS18444.1 - 2e-63 212.8 0.2 2.3e-63 212.6 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS18444.1 - 2.7e-35 121.2 0.2 3.9e-35 120.7 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS18444.1 - 3.2e-13 49.5 0.1 4.3e-13 49.1 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS18444.1 - 7.6e-08 32.4 0.1 1.2e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS18444.1 - 0.0002 20.9 0.1 0.00083 19.0 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS18444.1 - 0.00022 21.2 0.1 0.016 15.2 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 KOS18444.1 - 0.00033 20.1 0.1 0.0005 19.5 0.1 1.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KOS18444.1 - 0.0029 17.9 0.0 0.019 15.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain SRPRB PF09439.10 KOS18444.1 - 0.012 15.1 0.0 0.018 14.5 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_14 PF13173.6 KOS18444.1 - 0.014 15.4 0.1 0.042 13.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS18444.1 - 0.015 15.7 0.2 0.026 14.9 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 KOS18444.1 - 0.021 15.3 0.1 0.029 14.9 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOS18444.1 - 0.029 14.1 0.1 0.064 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 KOS18444.1 - 0.03 13.7 0.0 0.17 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein SpoIIID PF12116.8 KOS18444.1 - 0.088 12.9 0.1 1.7 8.8 0.0 2.2 2 0 0 2 2 2 0 Stage III sporulation protein D AAA_21 PF13304.6 KOS18444.1 - 0.093 12.5 0.6 0.15 11.8 0.5 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system FeoB_N PF02421.18 KOS18444.1 - 0.093 12.3 0.1 0.24 10.9 0.0 1.6 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_7 PF12775.7 KOS18444.1 - 0.12 11.9 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Pex14_N PF04695.13 KOS18445.1 - 3.8e-34 118.6 0.0 3.8e-34 118.6 0.0 2.9 2 1 1 3 3 3 1 Peroxisomal membrane anchor protein (Pex14p) conserved region ATG16 PF08614.11 KOS18445.1 - 0.0076 16.5 0.3 0.0076 16.5 0.3 2.7 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) Brix PF04427.18 KOS18447.1 - 4.2e-38 131.4 0.0 5.2e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 Brix domain Arb2 PF09757.9 KOS18449.1 - 2.9e-102 341.2 0.4 3.8e-102 340.8 0.4 1.1 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 KOS18449.1 - 2.2e-80 270.4 0.0 3.3e-80 269.8 0.0 1.3 1 0 0 1 1 1 1 Histone deacetylase domain Fungal_trans PF04082.18 KOS18451.1 - 2.6e-23 82.4 0.0 5e-23 81.5 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain efThoc1 PF11957.8 KOS18451.1 - 0.024 13.3 0.1 0.035 12.8 0.1 1.1 1 0 0 1 1 1 0 THO complex subunit 1 transcription elongation factor Menin PF05053.13 KOS18452.1 - 0.065 11.6 6.8 0.076 11.4 6.8 1.1 1 0 0 1 1 1 0 Menin NST1 PF13945.6 KOS18452.1 - 6.1 6.9 12.3 7.9 6.5 12.3 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Peptidase_C48 PF02902.19 KOS18453.1 - 6.1e-24 85.1 0.0 8.9e-24 84.5 0.0 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain GTP_EFTU PF00009.27 KOS18454.1 - 1.4e-57 194.4 0.2 1.9e-57 193.9 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 KOS18454.1 - 4.9e-27 94.4 0.0 1e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 KOS18454.1 - 5.1e-17 62.0 2.5 1.8e-16 60.3 2.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOS18454.1 - 1.4e-05 25.1 0.1 2.8e-05 24.2 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS18454.1 - 0.0011 18.9 0.0 0.003 17.5 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase cobW PF02492.19 KOS18454.1 - 0.023 14.3 0.2 0.14 11.7 0.0 2.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PduV-EutP PF10662.9 KOS18454.1 - 0.08 12.7 0.2 14 5.4 0.0 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Gtr1_RagA PF04670.12 KOS18454.1 - 0.19 11.0 0.1 0.69 9.2 0.1 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Proteasome PF00227.26 KOS18455.1 - 3e-38 131.2 0.0 3.7e-38 130.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 KOS18456.1 - 3.7e-22 78.2 4.3 1.4e-05 25.7 0.0 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18456.1 - 0.012 15.8 0.0 0.54 10.6 0.0 3.3 3 1 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain CNDH2_C PF16858.5 KOS18456.1 - 0.032 14.1 0.9 0.061 13.2 0.9 1.4 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nup160 PF11715.8 KOS18456.1 - 0.039 12.6 0.0 0.62 8.6 0.1 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PQQ_3 PF13570.6 KOS18456.1 - 0.047 14.2 0.4 1.3 9.6 0.1 3.3 3 0 0 3 3 3 0 PQQ-like domain WD40_like PF17005.5 KOS18456.1 - 0.089 12.1 0.0 0.49 9.7 0.0 2.1 2 1 0 3 3 3 0 WD40-like domain AMP-binding PF00501.28 KOS18457.1 - 4.6e-08 32.1 0.2 5.3e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 AMP-binding enzyme DUF4856 PF16148.5 KOS18457.1 - 0.19 10.7 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4856) DEAD PF00270.29 KOS18458.1 - 1.4e-47 161.7 0.0 5.6e-47 159.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS18458.1 - 7.3e-33 113.2 0.0 1.7e-32 112.1 0.0 1.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS18458.1 - 0.039 13.9 0.0 0.075 13.0 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 KOS18458.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 KOS18458.1 - 0.12 11.8 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF676 PF05057.14 KOS18459.1 - 4.2e-05 23.2 0.0 7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 KOS18459.1 - 0.0001 22.1 0.1 0.00025 20.8 0.0 1.6 1 1 0 1 1 1 1 PGAP1-like protein Hydrolase_4 PF12146.8 KOS18459.1 - 0.00047 19.5 0.0 0.00088 18.6 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOS18459.1 - 0.00047 20.8 8.3 0.00047 20.8 8.3 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family CENP-Q PF13094.6 KOS18459.1 - 0.0053 17.0 12.7 0.013 15.7 12.7 1.6 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Abhydrolase_1 PF00561.20 KOS18459.1 - 0.018 14.7 3.7 0.032 13.9 0.1 2.3 2 0 0 2 2 2 0 alpha/beta hydrolase fold Tho2 PF11262.8 KOS18459.1 - 0.13 11.4 2.5 0.19 10.9 2.5 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Exonuc_VII_L PF02601.15 KOS18459.1 - 0.28 10.7 4.9 0.41 10.2 4.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 KOS18459.1 - 0.33 10.3 9.0 0.53 9.6 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 KOS18459.1 - 0.44 8.4 0.7 0.57 8.0 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 KOS18459.1 - 2.8 7.6 7.4 4.2 7.1 7.4 1.2 1 0 0 1 1 1 0 AAA domain DUF3292 PF11696.8 KOS18459.1 - 6.5 5.0 8.2 11 4.2 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) YlqD PF11068.8 KOS18459.1 - 9.7 6.6 11.8 17 5.8 11.8 1.4 1 0 0 1 1 1 0 YlqD protein HET PF06985.11 KOS18460.1 - 3.5e-16 59.9 0.0 6e-16 59.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) NOA36 PF06524.12 KOS18460.1 - 1.9 7.7 12.5 4.5 6.5 12.5 1.6 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 KOS18460.1 - 2 8.5 3.3 3.9 7.5 3.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 KOS18460.1 - 4.6 7.1 6.8 7.8 6.3 6.8 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Mito_carr PF00153.27 KOS18461.1 - 1.1e-45 153.4 3.3 2.5e-17 62.6 0.0 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 KOS18461.1 - 0.00079 18.7 0.3 0.017 14.3 0.0 2.2 2 0 0 2 2 2 2 Gammaproteobacterial serine protease DUF3337 PF11816.8 KOS18462.1 - 2.2e-53 180.6 0.0 1.3e-52 178.2 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 KOS18462.1 - 2.4e-16 59.8 15.0 0.0016 19.2 0.4 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 KOS18462.1 - 0.15 10.7 0.6 0.34 9.5 0.0 1.8 2 1 0 3 3 3 0 Nucleoporin Nup120/160 KH_1 PF00013.29 KOS18463.1 - 2.7e-47 158.5 13.7 8.4e-17 60.8 0.7 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 KOS18463.1 - 2.3e-12 46.6 1.1 0.015 15.1 0.0 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 KOS18463.1 - 4.8e-09 36.0 5.4 0.1 12.5 0.2 3.4 3 0 0 3 3 3 3 KH domain KH_5 PF13184.6 KOS18463.1 - 0.00019 21.5 2.6 0.89 9.7 0.1 3.4 3 0 0 3 3 3 2 NusA-like KH domain MOEP19 PF16005.5 KOS18463.1 - 0.0023 17.9 0.0 1.7 8.7 0.0 3.1 3 0 0 3 3 3 1 KH-like RNA-binding domain 6PF2K PF01591.18 KOS18464.1 - 2.5e-78 262.4 0.0 3.3e-78 262.0 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOS18464.1 - 5.4e-34 117.6 0.0 9.9e-34 116.7 0.0 1.5 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 KOS18464.1 - 1.1e-06 28.9 0.0 2.1e-06 28.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 KOS18464.1 - 0.0008 18.9 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Flavin_Reduct PF01613.18 KOS18465.1 - 1e-19 71.1 0.1 1.6e-19 70.5 0.1 1.2 1 0 0 1 1 1 1 Flavin reductase like domain PDEase_II PF02112.15 KOS18466.1 - 1.3e-53 182.3 0.1 5.5e-21 75.0 0.0 3.2 3 0 0 3 3 3 3 cAMP phosphodiesterases class-II DEAD PF00270.29 KOS18467.1 - 2.5e-45 154.4 1.4 2.7e-45 154.3 0.2 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS18467.1 - 1.9e-28 99.0 0.6 7.2e-28 97.2 0.1 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain UTP25 PF06862.12 KOS18467.1 - 0.0022 16.8 1.1 0.041 12.6 0.0 2.8 1 1 2 3 3 3 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 EB1 PF03271.17 KOS18468.1 - 2.9e-16 59.4 1.5 5.9e-16 58.4 1.5 1.5 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 KOS18468.1 - 1.1e-06 28.8 0.3 1.7e-06 28.2 0.3 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain CH_2 PF06294.11 KOS18468.1 - 0.046 13.8 0.1 0.07 13.2 0.1 1.4 1 0 0 1 1 1 0 CH-like domain in sperm protein PX PF00787.24 KOS18469.1 - 5.3e-16 58.6 0.0 9e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 PX domain YqfQ PF14181.6 KOS18469.1 - 3.2 7.9 12.5 0.7 10.1 8.0 2.1 2 0 0 2 2 2 0 YqfQ-like protein DUF1664 PF07889.12 KOS18469.1 - 5.8 7.0 6.6 21 5.2 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 KOS18469.1 - 7.9 7.0 8.5 8.7 6.9 7.2 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 Spectrin PF00435.21 KOS18469.1 - 9.9 6.7 10.2 2.2 8.8 0.1 2.8 3 1 0 3 3 3 0 Spectrin repeat WD40 PF00400.32 KOS18471.1 - 4.9e-33 112.6 13.7 1.8e-06 28.5 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat F-box PF00646.33 KOS18471.1 - 3.2e-08 33.3 0.0 6.9e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS18471.1 - 7.2e-08 32.2 0.1 1.5e-07 31.2 0.1 1.6 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 KOS18471.1 - 1.2e-06 28.7 0.1 0.017 15.4 0.0 4.5 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS18471.1 - 7.7e-06 24.8 0.7 0.48 9.0 0.0 3.9 2 1 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 KOS18471.1 - 0.011 14.3 0.1 0.031 12.8 0.0 1.8 2 0 0 2 2 2 0 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 KOS18471.1 - 0.079 11.9 0.1 0.98 8.3 0.0 2.4 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Pectate_lyase_3 PF12708.7 KOS18472.1 - 4.6e-93 311.0 11.6 3.6e-83 278.6 7.0 3.6 4 1 0 4 4 4 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 KOS18472.1 - 1.3e-06 28.0 1.2 0.0065 16.1 0.3 2.6 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase ANATO PF01821.18 KOS18472.1 - 0.16 12.9 0.0 0.41 11.6 0.0 1.7 1 0 0 1 1 1 0 Anaphylotoxin-like domain Lactamase_B_4 PF13691.6 KOS18474.1 - 3.1e-20 71.6 0.0 7.7e-19 67.1 0.0 2.8 3 0 0 3 3 3 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 KOS18474.1 - 1.3e-17 64.0 0.3 2.5e-17 63.1 0.3 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOS18474.1 - 0.0054 16.7 0.6 0.013 15.5 0.1 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily LIM_bind PF01803.16 KOS18475.1 - 5.8e-75 251.9 0.0 5.8e-75 251.9 0.0 4.4 2 1 2 4 4 4 1 LIM-domain binding protein DUF4457 PF14652.6 KOS18475.1 - 2.7 7.2 4.3 43 3.2 4.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4457) HbrB PF08539.11 KOS18476.1 - 1.5e-51 174.8 0.0 3.1e-51 173.7 0.0 1.6 1 0 0 1 1 1 1 HbrB-like Bacillus_PapR PF05968.11 KOS18477.1 - 0.00017 21.4 0.8 2.2 8.2 0.0 3.8 3 0 0 3 3 3 2 Bacillus PapR protein Gon7 PF08738.10 KOS18478.1 - 8.2e-09 35.5 0.0 1.3e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Gon7 family PALP PF00291.25 KOS18480.1 - 8.1e-66 222.4 0.1 9.3e-66 222.2 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme WSC PF01822.19 KOS18481.1 - 2.3e-46 155.9 39.3 1.3e-15 57.3 8.7 3.7 3 0 0 3 3 3 3 WSC domain CENP-S PF15630.6 KOS18481.1 - 2.7e-34 117.4 0.0 4.5e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein peroxidase PF00141.23 KOS18481.1 - 5.4e-20 72.1 0.0 1.3e-19 70.8 0.0 1.6 1 0 0 1 1 1 1 Peroxidase CENP-T_C PF15511.6 KOS18481.1 - 5.9e-06 26.4 0.0 1.1e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 KOS18481.1 - 0.0018 18.2 0.0 0.0059 16.6 0.0 1.9 1 0 0 1 1 1 1 Bromodomain associated PALP PF00291.25 KOS18482.1 - 5.6e-53 180.3 0.9 9.2e-53 179.5 0.9 1.3 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3384 PF11864.8 KOS18483.1 - 2.1e-135 452.3 0.2 3.8e-135 451.5 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Rap_GAP PF02145.15 KOS18483.1 - 8.9e-55 185.1 0.0 1.5e-54 184.4 0.0 1.4 1 0 0 1 1 1 1 Rap/ran-GAP Tuberin PF03542.16 KOS18483.1 - 2.9e-39 135.2 0.1 5e-34 118.0 0.0 3.6 4 0 0 4 4 4 2 Tuberin UL2 PF08196.11 KOS18483.1 - 0.018 15.0 0.0 0.052 13.5 0.0 1.8 1 0 0 1 1 1 0 UL2 protein CENP-I PF07778.11 KOS18484.1 - 2.3e-27 95.9 0.0 9.7e-25 87.3 0.0 2.1 1 1 1 2 2 2 2 Mis6 ABC_tran PF00005.27 KOS18485.1 - 3.6e-13 50.2 0.1 8.2e-12 45.8 0.1 2.2 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOS18485.1 - 9.7e-10 38.7 1.5 0.00023 21.1 0.3 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF3584 PF12128.8 KOS18485.1 - 0.00039 18.1 0.4 0.00052 17.7 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) AAA_29 PF13555.6 KOS18485.1 - 0.00097 18.8 0.1 0.0022 17.7 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SRP54 PF00448.22 KOS18485.1 - 0.0031 17.2 0.1 0.0066 16.1 0.0 1.5 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_23 PF13476.6 KOS18485.1 - 0.0048 17.4 0.1 0.0073 16.8 0.1 1.2 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 KOS18485.1 - 0.0062 16.0 0.0 3.1 7.2 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 KOS18485.1 - 0.0092 15.7 0.0 0.012 15.3 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 KOS18485.1 - 0.017 15.4 0.8 0.039 14.2 0.2 1.8 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOS18485.1 - 0.018 15.4 0.0 0.16 12.4 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOS18485.1 - 0.023 14.3 0.1 0.055 13.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 KOS18485.1 - 0.048 13.4 0.0 0.076 12.8 0.0 1.3 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 KOS18485.1 - 0.05 13.9 0.1 0.16 12.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain AAA_13 PF13166.6 KOS18485.1 - 0.053 12.2 0.0 0.071 11.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOS18485.1 - 0.063 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 KOS18485.1 - 0.064 13.6 0.9 0.23 11.8 0.1 2.0 2 0 0 2 2 2 0 AAA ATPase domain Arf PF00025.21 KOS18485.1 - 0.09 12.2 0.3 0.21 11.0 0.3 1.6 1 1 0 1 1 1 0 ADP-ribosylation factor family Roc PF08477.13 KOS18485.1 - 0.15 12.3 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 KOS18485.1 - 0.16 12.1 0.1 0.32 11.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOS18485.1 - 0.16 12.0 0.1 1.1 9.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KOS18485.1 - 0.2 11.6 0.2 0.34 10.8 0.2 1.3 1 0 0 1 1 1 0 NACHT domain DNA_pol_E_B PF04042.16 KOS18486.1 - 6.4e-47 159.6 0.0 8.5e-47 159.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DNA_pol_D_N PF18018.1 KOS18486.1 - 9.9e-40 135.7 0.0 1.6e-39 135.0 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Shadoo PF14999.6 KOS18486.1 - 8.9 6.4 7.2 29 4.8 0.3 3.1 2 1 1 3 3 3 0 Shadow of prion protein, neuroprotective SDA1 PF05285.12 KOS18487.1 - 0.26 10.7 1.5 0.41 10.0 1.5 1.3 1 0 0 1 1 1 0 SDA1 CAS_CSE1 PF03378.15 KOS18488.1 - 1.9e-168 560.5 0.0 5.5e-168 559.1 0.0 1.8 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 KOS18488.1 - 2.2e-148 494.0 2.8 3.3e-148 493.5 2.8 1.2 1 0 0 1 1 1 1 Cse1 IBN_N PF03810.19 KOS18488.1 - 5.6e-15 55.0 0.1 3e-14 52.7 0.0 2.4 2 0 0 2 2 2 1 Importin-beta N-terminal domain V-ATPase_H_N PF03224.14 KOS18488.1 - 0.013 14.9 0.7 0.14 11.4 0.0 2.9 2 1 1 4 4 4 0 V-ATPase subunit H DUF1529 PF07485.11 KOS18488.1 - 0.094 12.6 0.0 0.8 9.6 0.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1259) UCH PF00443.29 KOS18489.1 - 6e-36 124.2 0.0 7.5e-31 107.5 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS18489.1 - 1.7e-07 31.1 0.0 0.16 11.6 0.0 3.3 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase Corona_nucleoca PF00937.18 KOS18489.1 - 7.8 5.4 11.1 13 4.7 11.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein FSA_C PF10479.9 KOS18489.1 - 8.8 4.3 6.5 13 3.7 6.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus F-box-like PF12937.7 KOS18490.1 - 0.035 14.0 0.2 0.079 12.9 0.2 1.6 1 0 0 1 1 1 0 F-box-like CysA_C_terminal PF17850.1 KOS18490.1 - 0.058 14.0 2.1 2.4 8.8 0.2 3.3 2 0 0 2 2 2 0 CysA C-terminal regulatory domain CENP-B_dimeris PF09026.10 KOS18490.1 - 7.2 7.1 6.6 14 6.2 0.1 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ATG11 PF10377.9 KOS18491.1 - 7.3e-44 148.9 0.3 7.3e-44 148.9 0.3 4.1 3 1 1 4 4 4 1 Autophagy-related protein 11 Taxilin PF09728.9 KOS18491.1 - 7e-06 25.4 13.6 7e-06 25.4 13.6 5.3 4 1 1 5 5 5 1 Myosin-like coiled-coil protein ATG16 PF08614.11 KOS18491.1 - 5.3e-05 23.5 26.9 5.3e-05 23.5 26.9 7.5 5 1 2 7 7 7 2 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 KOS18491.1 - 0.001 18.5 8.0 0.001 18.5 8.0 5.7 3 1 2 5 5 4 2 Domain of unknown function (DUF4407) MscS_porin PF12795.7 KOS18491.1 - 0.0011 18.6 29.9 0.0011 18.6 29.9 6.0 4 1 2 6 6 5 1 Mechanosensitive ion channel porin domain APG17 PF04108.12 KOS18491.1 - 0.0019 17.4 11.8 0.0019 17.4 11.8 6.0 2 2 2 5 5 5 1 Autophagy protein Apg17 zf-C4H2 PF10146.9 KOS18491.1 - 0.0028 18.0 5.6 0.0028 18.0 5.6 5.8 4 2 2 6 6 6 1 Zinc finger-containing protein Bacillus_HBL PF05791.11 KOS18491.1 - 0.019 14.8 30.0 1.4 8.7 0.5 6.1 4 1 1 5 5 5 0 Bacillus haemolytic enterotoxin (HBL) HATPase_c_4 PF13749.6 KOS18491.1 - 0.089 12.9 0.1 0.46 10.7 0.0 2.2 2 0 0 2 2 2 0 Putative ATP-dependent DNA helicase recG C-terminal NuA4 PF09340.10 KOS18491.1 - 0.13 12.2 0.1 0.13 12.2 0.1 4.2 4 0 0 4 4 3 0 Histone acetyltransferase subunit NuA4 DUF812 PF05667.11 KOS18491.1 - 1.3 7.9 66.1 0.064 12.1 17.0 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF812) HOOK PF05622.12 KOS18491.1 - 7.6 4.5 74.4 1.1 7.3 62.1 3.2 3 0 0 3 3 3 0 HOOK protein CENP-H PF05837.12 KOS18492.1 - 2.4e-36 124.5 1.5 9.2e-34 116.2 0.4 2.1 2 0 0 2 2 2 2 Centromere protein H (CENP-H) VIT1 PF01988.19 KOS18494.1 - 3.1e-59 200.5 0.0 1.3e-58 198.4 0.0 1.8 1 1 0 1 1 1 1 VIT family DNA_pol_phi PF04931.13 KOS18494.1 - 0.09 10.9 4.1 0.11 10.5 4.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 KOS18494.1 - 1.9 8.2 5.7 2.7 7.7 5.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Phosphoesterase PF04185.14 KOS18495.1 - 1.1e-27 97.2 2.0 4.9e-26 91.8 2.0 2.1 1 1 0 1 1 1 1 Phosphoesterase family DUF3802 PF12290.8 KOS18496.1 - 0.034 14.6 0.0 0.063 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3802) CW_binding_1 PF01473.20 KOS18496.1 - 0.057 13.8 1.0 0.11 12.8 1.0 1.5 1 0 0 1 1 1 0 Putative cell wall binding repeat FAD_binding_3 PF01494.19 KOS18497.1 - 2.1e-19 70.0 0.1 9e-18 64.6 0.1 2.2 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS18497.1 - 4.1e-05 23.3 1.1 0.0091 15.6 1.1 2.2 1 1 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOS18497.1 - 0.00041 19.5 1.9 0.003 16.6 0.3 2.4 3 0 0 3 3 3 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 KOS18497.1 - 0.00053 19.3 0.0 0.0013 18.0 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS18497.1 - 0.008 16.2 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 KOS18497.1 - 0.011 15.0 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.6 KOS18497.1 - 0.017 15.4 0.0 0.21 11.8 0.1 2.7 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain SE PF08491.10 KOS18497.1 - 0.036 13.1 0.0 0.059 12.4 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase K_oxygenase PF13434.6 KOS18497.1 - 0.064 12.4 0.0 0.095 11.8 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Trp_halogenase PF04820.14 KOS18497.1 - 0.076 11.8 0.0 1.1 8.0 0.0 2.3 2 1 0 2 2 2 0 Tryptophan halogenase Complex1_49kDa PF00346.19 KOS18498.1 - 3.8e-123 409.9 0.0 5.2e-123 409.4 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit NiFeSe_Hases PF00374.19 KOS18498.1 - 0.0025 16.8 0.0 0.0044 16.0 0.0 1.4 1 1 0 1 1 1 1 Nickel-dependent hydrogenase Pyr_redox_2 PF07992.14 KOS18499.1 - 2.4e-48 164.9 0.8 2.8e-48 164.6 0.8 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS18499.1 - 3.3e-17 62.7 0.0 1.5e-15 57.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS18499.1 - 3.8e-17 62.6 1.1 3.2e-14 53.2 0.1 3.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 KOS18499.1 - 9.1e-05 22.8 0.0 0.052 14.0 0.0 2.5 2 1 0 2 2 2 2 Putative NAD(P)-binding DAO PF01266.24 KOS18499.1 - 0.00022 20.9 1.4 0.3 10.6 0.0 3.3 3 1 1 4 4 4 2 FAD dependent oxidoreductase Thi4 PF01946.17 KOS18499.1 - 0.0004 19.7 0.3 0.0011 18.3 0.0 1.8 2 0 0 2 2 2 1 Thi4 family GIDA PF01134.22 KOS18499.1 - 0.00059 19.0 4.7 0.034 13.2 0.3 3.6 3 1 1 4 4 4 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOS18499.1 - 0.00074 19.0 0.1 0.0044 16.4 0.0 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS18499.1 - 0.0017 18.6 0.2 0.056 13.7 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOS18499.1 - 0.0025 16.9 5.7 0.044 12.9 0.3 3.0 3 1 0 3 3 3 2 FAD binding domain HI0933_like PF03486.14 KOS18499.1 - 0.011 14.5 0.1 0.97 8.1 0.1 2.7 2 1 1 3 3 3 0 HI0933-like protein Shikimate_DH PF01488.20 KOS18499.1 - 0.018 15.1 0.2 18 5.4 0.0 3.3 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 KOS18499.1 - 0.074 13.0 0.0 1.8 8.5 0.0 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOS18499.1 - 0.11 11.6 0.1 2.1 7.4 0.0 2.7 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Vps53_N PF04100.12 KOS18500.1 - 3.9e-102 342.0 0.0 5.7e-102 341.5 0.0 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.13 KOS18500.1 - 8.8e-05 21.1 0.0 0.01 14.3 0.0 2.2 2 0 0 2 2 2 2 Exocyst complex component Sec6 DUF2451 PF10474.9 KOS18500.1 - 0.00021 21.2 0.0 0.00043 20.1 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) RINT1_TIP1 PF04437.13 KOS18500.1 - 0.00071 18.6 0.2 0.014 14.3 0.0 2.7 3 0 0 3 3 3 1 RINT-1 / TIP-1 family Vps54_N PF10475.9 KOS18500.1 - 0.0012 18.2 3.1 0.002 17.5 3.1 1.2 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex UPF0175 PF03683.13 KOS18500.1 - 0.02 14.6 0.0 1.6 8.5 0.0 3.5 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0175) Zw10 PF06248.13 KOS18500.1 - 0.027 13.1 3.2 0.044 12.3 3.2 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 FliG_N PF14842.6 KOS18500.1 - 0.082 13.5 0.1 1 10.0 0.0 2.6 2 0 0 2 2 2 0 FliG N-terminal domain DUF5082 PF16888.5 KOS18500.1 - 0.12 12.7 5.1 0.071 13.4 0.8 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) Spc7 PF08317.11 KOS18500.1 - 0.15 10.9 3.0 0.27 10.1 3.0 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Peptidase_M16 PF00675.20 KOS18501.1 - 1.9e-55 186.9 0.3 5e-55 185.6 0.3 1.7 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOS18501.1 - 3.6e-39 134.7 0.1 8.2e-39 133.5 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain TFIID-31kDa PF02291.15 KOS18502.1 - 1.4e-41 141.4 0.0 1.8e-41 141.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit CCDC53 PF10152.9 KOS18502.1 - 7.1 7.0 6.5 10 6.5 6.5 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Histidinol_dh PF00815.20 KOS18503.1 - 1.9e-159 531.0 4.3 2.8e-159 530.5 4.3 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 KOS18503.1 - 3.2e-23 81.4 0.0 5.7e-23 80.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 KOS18503.1 - 4.9e-13 49.3 1.6 6.2e-13 49.0 0.2 2.0 2 0 0 2 2 2 1 Phosphoribosyl-ATP pyrophosphohydrolase Phasin_2 PF09361.10 KOS18503.1 - 0.017 15.4 0.1 3.5 7.9 0.1 3.0 2 0 0 2 2 2 0 Phasin protein LNS2 PF08235.13 KOS18504.1 - 1e-93 313.0 0.0 1.5e-93 312.5 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 KOS18504.1 - 1.9e-43 146.5 0.0 3.8e-43 145.6 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 KOS18504.1 - 0.0032 17.1 0.0 0.17 11.5 0.0 2.6 2 0 0 2 2 2 1 HAD superfamily, subfamily IIIB (Acid phosphatase) zf-RING_2 PF13639.6 KOS18505.1 - 1.1e-11 44.9 6.7 1.6e-11 44.4 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOS18505.1 - 2.9e-08 33.3 0.9 4.8e-08 32.6 0.9 1.4 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOS18505.1 - 9.8e-08 31.7 6.4 1.5e-07 31.2 6.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS18505.1 - 1.7e-07 31.0 4.0 2.6e-07 30.4 4.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS18505.1 - 3.1e-06 27.4 9.3 1.7e-05 25.0 9.3 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 KOS18505.1 - 8.6e-06 25.6 3.9 1.2e-05 25.1 3.9 1.2 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOS18505.1 - 0.00084 19.3 1.9 0.0016 18.5 1.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOS18505.1 - 0.0009 19.1 2.9 0.0013 18.5 2.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS18505.1 - 0.002 18.1 1.0 0.002 18.1 1.0 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 KOS18505.1 - 0.014 15.2 7.0 0.022 14.6 7.0 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-UDP PF14569.6 KOS18505.1 - 0.017 15.3 1.3 0.046 13.8 1.3 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger Prok-RING_1 PF14446.6 KOS18505.1 - 0.049 13.6 1.8 0.049 13.6 1.8 2.3 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Prok-RING_4 PF14447.6 KOS18505.1 - 0.15 12.0 4.6 0.35 10.8 4.7 1.5 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 PHD PF00628.29 KOS18505.1 - 0.2 11.6 5.9 0.37 10.7 5.9 1.5 1 0 0 1 1 1 0 PHD-finger Zn_ribbon_17 PF17120.5 KOS18505.1 - 0.24 11.1 4.8 0.4 10.3 4.8 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Baculo_IE-1 PF05290.11 KOS18505.1 - 0.25 11.3 1.3 0.37 10.7 1.3 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) FANCL_C PF11793.8 KOS18505.1 - 1.2 9.4 4.8 3.8 7.7 4.8 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3H2C3 PF17122.5 KOS18505.1 - 2.7 8.1 7.2 6.8 6.8 7.2 1.8 1 1 0 1 1 1 0 Zinc-finger DUF3752 PF12572.8 KOS18506.1 - 2.1e-45 155.0 3.0 3.8e-45 154.1 3.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3752) UDG PF03167.19 KOS18507.1 - 8.9e-21 74.5 0.0 1.1e-20 74.2 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily UDPGP PF01704.18 KOS18508.1 - 7.6e-53 179.6 0.0 9.7e-53 179.3 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase YhcG_C PF06250.11 KOS18508.1 - 0.057 13.2 0.0 0.094 12.5 0.0 1.3 1 0 0 1 1 1 0 YhcG PDDEXK nuclease domain Zip PF02535.22 KOS18510.1 - 2.2e-32 112.6 0.4 6.1e-21 75.0 0.1 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter DctQ PF04290.12 KOS18510.1 - 0.048 13.6 0.4 0.048 13.6 0.4 2.2 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DnaJ PF00226.31 KOS18511.1 - 3.3e-16 59.2 0.6 9.2e-16 57.7 0.6 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 KOS18511.1 - 1.7e-10 40.5 0.0 4.6e-09 35.8 0.0 2.4 1 1 0 1 1 1 1 Sec63 Brl domain DUF3336 PF11815.8 KOS18512.1 - 1.1e-47 161.2 2.5 1.8e-47 160.5 2.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOS18512.1 - 4.5e-18 66.2 0.5 1.3e-17 64.7 0.0 2.1 2 0 0 2 2 2 1 Patatin-like phospholipase Esterase PF00756.20 KOS18514.1 - 1.3e-49 169.1 0.0 1.5e-49 168.9 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Esterase_phd PF10503.9 KOS18514.1 - 1.4e-05 24.7 0.1 4.5e-05 23.1 0.1 1.7 1 1 0 1 1 1 1 Esterase PHB depolymerase Hydrolase_4 PF12146.8 KOS18514.1 - 0.011 15.0 0.1 0.042 13.1 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOS18514.1 - 0.019 14.5 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family Chlorophyllase2 PF12740.7 KOS18514.1 - 0.023 13.6 0.0 0.11 11.4 0.0 1.9 2 0 0 2 2 2 0 Chlorophyllase enzyme AXE1 PF05448.12 KOS18514.1 - 0.045 12.4 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) zf-C2H2 PF00096.26 KOS18515.1 - 3e-30 103.0 45.8 0.00036 20.8 1.4 10.5 10 0 0 10 10 10 7 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS18515.1 - 3.6e-25 86.5 47.1 0.0046 17.7 1.3 10.7 10 0 0 10 10 10 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOS18515.1 - 1.1e-16 60.4 53.8 0.00082 19.7 1.6 11.3 12 0 0 12 12 12 5 Zinc-finger double domain FOXP-CC PF16159.5 KOS18515.1 - 4e-07 30.6 35.4 0.0094 16.6 0.2 7.8 4 2 5 9 9 8 2 FOXP coiled-coil domain zf-Di19 PF05605.12 KOS18515.1 - 0.00016 21.9 35.9 0.78 10.1 0.8 7.7 5 3 3 8 8 8 4 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_8 PF15909.5 KOS18515.1 - 0.00026 21.2 14.6 0.0053 17.0 3.8 4.7 3 1 1 4 4 4 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 KOS18515.1 - 0.013 15.7 24.9 1.7 9.0 1.8 7.6 7 1 0 7 7 7 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS18515.1 - 0.019 15.4 13.9 2.4 8.7 0.1 6.1 6 0 0 6 6 5 0 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 KOS18515.1 - 0.022 15.4 20.9 4.3 8.0 5.1 5.5 3 2 1 5 5 5 0 Zinc finger C2H2-type, 3 repeats IBR PF01485.21 KOS18515.1 - 0.025 14.8 0.4 0.025 14.8 0.4 5.8 1 1 3 5 5 5 0 IBR domain, a half RING-finger domain zf-C2H2_aberr PF17017.5 KOS18515.1 - 0.071 13.2 14.6 21 5.2 0.9 4.8 3 2 0 3 3 3 0 Aberrant zinc-finger zf-C2H2_9 PF16293.5 KOS18515.1 - 0.078 12.8 6.2 2.9 7.8 0.1 4.4 4 0 0 4 4 4 0 C2H2 type zinc-finger (1 copy) zinc_ribbon_4 PF13717.6 KOS18515.1 - 0.097 12.6 5.2 5.9 6.9 0.0 3.5 3 0 0 3 3 3 0 zinc-ribbon domain zf_C2H2_ZHX PF18387.1 KOS18515.1 - 0.22 11.2 0.1 0.22 11.2 0.1 4.6 4 0 0 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 KOS18515.1 - 1.1 9.6 24.2 0.26 11.6 0.2 5.6 5 2 2 7 7 6 0 C2H2 type zinc-finger (2 copies) Elf1 PF05129.13 KOS18515.1 - 3.5 7.8 8.2 12 6.1 3.4 3.7 3 1 0 3 3 3 0 Transcription elongation factor Elf1 like Zn-ribbon_8 PF09723.10 KOS18515.1 - 3.6 7.8 14.4 6.9 6.9 2.4 4.3 3 1 2 5 5 5 0 Zinc ribbon domain CHORD PF04968.12 KOS18515.1 - 7.3 7.4 20.7 14 6.5 0.3 6.1 4 1 3 7 7 7 0 CHORD zf-C2H2_6 PF13912.6 KOS18515.1 - 9.6 6.3 28.7 1.4 9.0 1.6 6.2 7 0 0 7 7 7 0 C2H2-type zinc finger RNA_pol_Rpb6 PF01192.22 KOS18516.1 - 1.4e-17 63.3 0.6 3.4e-17 62.1 0.1 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb6 Pox_RNA_Pol_19 PF05320.12 KOS18516.1 - 2.4 8.1 4.7 9.3 6.2 4.7 1.7 1 1 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Afi1 PF07792.12 KOS18517.1 - 9.5e-45 152.3 0.6 1.7e-44 151.5 0.6 1.5 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SPA PF08616.10 KOS18517.1 - 1.3e-36 125.0 0.0 2.3e-36 124.2 0.0 1.4 1 0 0 1 1 1 1 Stabilization of polarity axis Avl9 PF09794.9 KOS18517.1 - 1.8e-08 33.5 0.1 0.025 13.3 0.0 4.0 3 1 1 4 4 4 3 Transport protein Avl9 Cwf_Cwc_15 PF04889.12 KOS18517.1 - 0.074 12.8 7.6 0.13 11.9 7.6 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 KOS18517.1 - 0.099 11.8 3.5 0.15 11.1 3.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2347 PF09804.9 KOS18517.1 - 0.18 11.4 0.0 0.63 9.6 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) EF-hand_6 PF13405.6 KOS18518.1 - 3.7e-12 45.1 0.0 6.3e-05 22.6 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 KOS18518.1 - 6.1e-10 37.9 0.9 0.00046 19.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 KOS18518.1 - 1e-08 35.5 0.3 1.1e-06 28.9 0.0 1.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 KOS18518.1 - 4.5e-07 29.6 0.0 0.026 14.4 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOS18518.1 - 4e-05 22.9 2.4 0.038 13.5 0.2 2.3 2 0 0 2 2 2 2 EF hand DUF5427 PF10310.9 KOS18518.1 - 0.011 14.7 1.4 0.013 14.5 1.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) EF-hand_9 PF14658.6 KOS18518.1 - 0.025 14.9 0.0 1.3 9.4 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain ANKH PF07260.11 KOS18518.1 - 0.63 9.2 1.1 2.3 7.3 1.6 1.6 2 0 0 2 2 2 0 Progressive ankylosis protein (ANKH) SOG2 PF10428.9 KOS18518.1 - 2.1 7.4 14.4 3.2 6.9 14.4 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Methyltransf_31 PF13847.6 KOS18519.1 - 3.8e-16 59.3 0.0 7.7e-11 42.0 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KOS18519.1 - 5.2e-08 33.6 0.0 1.5e-07 32.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS18519.1 - 1.4e-07 32.1 0.0 9.3e-07 29.5 0.0 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS18519.1 - 4e-07 30.0 0.0 1.8e-06 27.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS18519.1 - 2.7e-06 27.9 0.0 2.4e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS18519.1 - 0.00058 19.9 0.0 0.00085 19.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 KOS18519.1 - 0.00058 20.2 0.0 0.0011 19.3 0.0 1.4 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase MTS PF05175.14 KOS18519.1 - 0.003 17.1 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain MetW PF07021.12 KOS18519.1 - 0.016 14.8 0.0 0.026 14.1 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF4611 PF15387.6 KOS18519.1 - 0.019 15.2 2.3 0.038 14.2 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Ubie_methyltran PF01209.18 KOS18519.1 - 0.02 14.2 0.0 0.034 13.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family SDA1 PF05285.12 KOS18519.1 - 0.057 12.8 2.1 0.065 12.6 2.1 1.1 1 0 0 1 1 1 0 SDA1 Methyltransf_4 PF02390.17 KOS18519.1 - 0.076 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase PrmA PF06325.13 KOS18519.1 - 0.086 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CDC45 PF02724.14 KOS18519.1 - 0.32 9.2 4.6 0.44 8.8 4.6 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOS18519.1 - 0.4 10.0 8.5 0.62 9.3 8.5 1.3 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 KOS18519.1 - 0.42 10.7 4.9 0.6 10.2 4.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein PBP1_TM PF14812.6 KOS18519.1 - 0.51 10.7 6.3 1.1 9.7 6.3 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 KOS18519.1 - 1 7.4 5.0 1.4 7.0 5.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 KOS18519.1 - 3.6 6.1 8.1 5.6 5.4 8.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cwf_Cwc_15 PF04889.12 KOS18519.1 - 4 7.1 8.5 6.5 6.4 8.5 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 KOS18519.1 - 5.5 7.4 12.4 14 6.2 12.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 KOS18519.1 - 6 6.5 5.1 1.2 8.7 1.7 1.5 2 0 0 2 2 2 0 FAM176 family DUF2457 PF10446.9 KOS18519.1 - 7.6 5.6 11.5 11 5.0 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ADH_zinc_N PF00107.26 KOS18520.1 - 4.3e-24 85.0 0.3 5.3e-24 84.7 0.3 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS18520.1 - 4.8e-16 60.0 0.0 6.9e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOS18520.1 - 0.028 13.7 0.0 0.13 11.5 0.0 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DAGK_cat PF00781.24 KOS18520.1 - 0.052 13.2 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain DUF2464 PF10240.9 KOS18521.1 - 0.17 11.4 0.3 0.25 10.9 0.3 1.3 1 0 0 1 1 1 0 Multivesicular body subunit 12 efThoc1 PF11957.8 KOS18522.1 - 4.9e-134 447.7 0.0 9e-134 446.8 0.0 1.3 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Guanylate_kin PF00625.21 KOS18522.1 - 5.6e-20 71.8 0.0 3.3e-19 69.3 0.0 2.0 1 1 1 2 2 2 1 Guanylate kinase Fer2_3 PF13085.6 KOS18523.1 - 3.2e-33 114.0 0.0 5.6e-33 113.2 0.0 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 KOS18523.1 - 1.6e-08 35.0 5.9 1.6e-08 35.0 5.9 2.3 3 0 0 3 3 3 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KOS18523.1 - 3.2e-08 33.9 11.1 9.6e-07 29.2 10.0 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOS18523.1 - 4e-08 33.3 2.6 4e-08 33.3 2.6 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 KOS18523.1 - 0.002 18.1 3.5 0.0025 17.8 0.3 2.3 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 KOS18523.1 - 0.0038 17.8 5.1 0.0038 17.8 5.1 2.5 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_18 PF13746.6 KOS18523.1 - 0.0087 16.2 0.5 0.3 11.3 0.1 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOS18523.1 - 0.4 10.9 13.0 1.6 9.0 10.0 2.9 2 1 2 4 4 4 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOS18523.1 - 0.62 11.0 10.4 1.5 9.8 1.6 3.0 3 0 0 3 3 3 0 4Fe-4S double cluster binding domain Aquarius_N PF16399.5 KOS18524.1 - 0 1067.3 0.0 0 1067.0 0.0 1.1 1 0 0 1 1 1 1 Intron-binding protein aquarius N-terminus AAA_12 PF13087.6 KOS18524.1 - 2.1e-28 99.3 0.0 3.6e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOS18524.1 - 1.4e-20 74.2 0.0 2e-09 37.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 KOS18524.1 - 1.4e-07 31.4 0.4 0.00079 19.2 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.6 KOS18524.1 - 1.2e-06 28.9 0.4 5.9e-05 23.4 0.0 2.7 3 0 0 3 3 3 1 AAA domain ResIII PF04851.15 KOS18524.1 - 7.7e-06 26.0 0.0 1.7e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA PF00004.29 KOS18524.1 - 0.0013 19.1 0.0 0.0059 17.0 0.0 2.2 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOS18524.1 - 0.0013 19.1 0.5 0.0099 16.3 0.0 2.7 3 0 0 3 3 3 1 AAA ATPase domain DnaB_C PF03796.15 KOS18524.1 - 0.0086 15.4 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Viral_helicase1 PF01443.18 KOS18524.1 - 0.015 15.0 0.1 4.6 6.9 0.0 3.5 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 KOS18524.1 - 0.018 15.3 0.8 0.2 11.9 0.1 2.8 2 1 1 3 3 3 0 AAA domain FANCI_S1-cap PF14674.6 KOS18524.1 - 0.04 14.0 0.4 0.11 12.6 0.4 1.7 1 0 0 1 1 1 0 FANCI solenoid 1 cap DUF2075 PF09848.9 KOS18524.1 - 0.063 12.5 0.6 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 KOS18524.1 - 0.14 11.3 0.0 0.23 10.5 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 RNA_helicase PF00910.22 KOS18524.1 - 0.15 12.4 0.0 0.47 10.9 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 KOS18524.1 - 0.19 11.0 0.3 0.52 9.6 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin ATPase_2 PF01637.18 KOS18524.1 - 0.19 11.6 0.0 0.39 10.6 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea DEAD PF00270.29 KOS18524.1 - 0.22 11.3 0.0 0.22 11.3 0.0 1.8 2 0 0 2 2 1 0 DEAD/DEAH box helicase NB-ARC PF00931.22 KOS18524.1 - 0.23 10.6 0.0 0.39 9.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain UvrD-helicase PF00580.21 KOS18524.1 - 1.2 8.5 3.6 1.8 8.0 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain MBOAT PF03062.19 KOS18525.1 - 2e-20 73.5 16.3 2e-20 73.5 16.3 1.8 2 0 0 2 2 2 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 KOS18525.1 - 0.0016 18.6 2.7 0.0054 17.0 2.7 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family OSTbeta PF15048.6 KOS18525.1 - 0.056 13.6 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein LTV PF04180.14 KOS18526.1 - 2.7e-128 429.0 9.1 3.1e-128 428.8 9.1 1.0 1 0 0 1 1 1 1 Low temperature viability protein SBDS_C PF09377.10 KOS18527.1 - 1.1e-42 144.7 0.0 1.9e-42 143.9 0.0 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 KOS18527.1 - 2.9e-35 120.2 0.1 4.7e-35 119.5 0.1 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein DUF3439 PF11921.8 KOS18527.1 - 0.0053 16.7 15.0 0.011 15.7 15.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) FSA_C PF10479.9 KOS18527.1 - 2.5 6.2 7.3 3.2 5.8 7.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ribosomal_S13 PF00416.22 KOS18528.1 - 1.7e-56 190.1 2.8 1.9e-56 189.9 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 KOS18528.1 - 0.017 13.9 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) PP28 PF10252.9 KOS18528.1 - 0.14 12.6 0.3 0.34 11.4 0.3 1.6 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 RRM_1 PF00076.22 KOS18529.1 - 0.00012 21.8 0.1 0.00019 21.2 0.1 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Neur_chan_memb PF02932.16 KOS18529.1 - 0.12 12.4 0.8 0.16 12.0 0.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TRAP_alpha PF03896.16 KOS18530.1 - 0.78 8.9 8.7 1 8.5 8.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 KOS18530.1 - 1.3 7.1 11.4 1.7 6.8 11.4 1.0 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 KOS18530.1 - 3.4 5.6 15.1 4.2 5.4 15.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 KOS18530.1 - 7.3 6.6 10.2 12 5.9 10.2 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 KOS18530.1 - 8.2 6.9 15.9 15 6.0 15.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Mob_synth_C PF06463.13 KOS18531.1 - 5.4e-36 123.4 0.0 2.9e-35 121.0 0.0 2.0 2 0 0 2 2 2 1 Molybdenum Cofactor Synthesis C Radical_SAM PF04055.21 KOS18531.1 - 5.8e-25 88.6 0.0 9.4e-25 87.9 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 KOS18531.1 - 8.5e-05 22.8 0.0 0.0003 21.1 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain MoaC PF01967.21 KOS18532.1 - 7.4e-54 181.5 6.1 9e-54 181.3 6.1 1.1 1 0 0 1 1 1 1 MoaC family FYVE PF01363.21 KOS18533.1 - 2e-15 56.7 6.7 3.8e-15 55.8 6.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger zf-AN1 PF01428.16 KOS18533.1 - 0.71 10.1 12.7 0.44 10.8 8.3 2.2 2 0 0 2 2 2 0 AN1-like Zinc finger ELO PF01151.18 KOS18534.1 - 2e-79 266.7 8.1 2.6e-79 266.3 8.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family DUF2976 PF11190.8 KOS18534.1 - 0.042 13.7 1.0 0.11 12.3 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Peptidase_S10 PF00450.22 KOS18535.1 - 1.5e-128 429.8 0.4 1.8e-128 429.5 0.4 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 KOS18535.1 - 2.1e-16 60.6 0.6 9e-16 58.6 0.6 2.0 1 1 0 1 1 1 1 Carboxypeptidase Y pro-peptide zf-TRAF_2 PF15965.5 KOS18535.1 - 0.15 12.5 0.5 0.29 11.6 0.5 1.4 1 0 0 1 1 1 0 TRAF-like zinc-finger tRNA-synt_1b PF00579.25 KOS18536.1 - 9.7e-18 64.5 0.2 3.9e-17 62.5 0.0 2.0 2 1 0 2 2 2 1 tRNA synthetases class I (W and Y) DUF1713 PF08213.11 KOS18536.1 - 0.37 10.8 2.7 0.89 9.5 2.7 1.7 1 0 0 1 1 1 0 Mitochondrial domain of unknown function (DUF1713) IF4E PF01652.18 KOS18537.1 - 3.8e-34 117.8 0.0 4.8e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Kinesin PF00225.23 KOS18538.1 - 1.7e-110 369.1 0.1 5.9e-110 367.3 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 KOS18538.1 - 8.2e-27 94.0 0.4 2.6e-25 89.1 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding RNA_pol_3_Rpc31 PF11705.8 KOS18538.1 - 0.089 13.0 11.0 0.25 11.6 11.0 1.8 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 GCIP PF13324.6 KOS18538.1 - 0.21 11.2 7.2 0.38 10.3 7.2 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF87 PF01935.17 KOS18538.1 - 0.78 9.8 0.0 0.78 9.8 0.0 2.9 3 1 0 3 3 3 0 Helicase HerA, central domain Nop25 PF09805.9 KOS18538.1 - 0.91 10.0 14.3 2.5 8.6 14.3 1.7 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Cwf_Cwc_15 PF04889.12 KOS18538.1 - 5 6.8 18.8 12 5.5 18.8 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein YabA PF06156.13 KOS18538.1 - 6.7 7.4 12.0 32 5.2 0.1 3.8 2 1 2 4 4 4 0 Initiation control protein YabA CpXC PF14353.6 KOS18538.1 - 8.7 6.4 6.6 39 4.3 6.5 2.2 1 1 0 1 1 1 0 CpXC protein HAGH_C PF16123.5 KOS18539.1 - 1.7e-21 76.5 0.7 2.6e-21 75.9 0.7 1.3 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 KOS18539.1 - 2e-18 67.1 2.4 3.9e-12 46.6 0.1 2.1 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOS18539.1 - 0.00012 21.7 1.4 0.0015 18.1 1.4 2.3 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF1236 PF06823.12 KOS18539.1 - 0.0046 16.8 0.1 0.061 13.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1236) EF-hand_9 PF14658.6 KOS18540.1 - 0.00053 20.3 0.0 0.011 16.0 0.0 2.5 2 1 0 2 2 2 1 EF-hand domain EF-hand_6 PF13405.6 KOS18540.1 - 0.005 16.7 0.0 12 6.1 0.0 4.1 4 1 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 KOS18540.1 - 0.069 13.6 0.0 9.7 6.7 0.0 2.3 2 0 0 2 2 2 0 EF-hand domain pair HA2 PF04408.23 KOS18541.1 - 1.4e-16 60.7 5.1 1.9e-16 60.3 0.0 2.9 3 0 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOS18541.1 - 2.6e-15 56.7 0.0 5.5e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOS18541.1 - 2.9e-15 56.4 0.0 6e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOS18541.1 - 1.2e-10 41.4 0.1 5e-10 39.4 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase RWD PF05773.22 KOS18541.1 - 9.3e-06 25.9 0.3 2.1e-05 24.8 0.3 1.6 1 0 0 1 1 1 1 RWD domain AAA_22 PF13401.6 KOS18541.1 - 0.0013 19.0 0.7 0.0062 16.8 0.7 2.0 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KOS18541.1 - 0.0033 17.0 0.1 0.0097 15.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOS18541.1 - 0.0066 15.8 0.1 0.02 14.2 0.0 1.7 2 0 0 2 2 2 1 KaiC AAA_29 PF13555.6 KOS18541.1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain dsRBD2 PF17842.1 KOS18541.1 - 0.016 15.4 0.6 0.083 13.1 0.0 2.3 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 DND1_DSRM PF14709.7 KOS18541.1 - 0.025 14.8 0.0 0.07 13.4 0.0 1.8 1 0 0 1 1 1 0 double strand RNA binding domain from DEAD END PROTEIN 1 T2SSE PF00437.20 KOS18541.1 - 0.025 13.7 0.0 0.052 12.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_23 PF13476.6 KOS18541.1 - 0.055 14.0 0.7 0.29 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 KOS18541.1 - 0.11 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein IstB_IS21 PF01695.17 KOS18541.1 - 0.14 11.8 0.3 1.5 8.6 0.2 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein IHABP4_N PF16174.5 KOS18541.1 - 0.56 10.8 10.2 0.14 12.7 0.4 2.5 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Arm PF00514.23 KOS18542.1 - 3.7e-95 309.4 16.3 2.7e-13 49.4 0.2 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 KOS18542.1 - 3e-27 94.9 2.7 4.4e-27 94.3 1.0 2.1 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 KOS18542.1 - 1.6e-24 85.2 4.0 3.5e-24 84.1 3.5 1.9 2 0 0 2 2 2 1 Atypical Arm repeat HEAT_EZ PF13513.6 KOS18542.1 - 2.2e-20 72.7 12.0 7.4e-09 35.9 0.1 6.7 5 1 2 7 7 7 4 HEAT-like repeat HEAT_2 PF13646.6 KOS18542.1 - 7.8e-19 67.9 1.6 1.5e-08 34.9 0.1 5.5 3 2 1 5 5 5 3 HEAT repeats HEAT PF02985.22 KOS18542.1 - 1e-16 59.6 2.6 1.7e-05 24.7 0.0 7.0 8 0 0 8 8 8 3 HEAT repeat Arm_2 PF04826.13 KOS18542.1 - 9.8e-08 31.8 0.0 0.12 11.9 0.0 4.1 2 1 2 4 4 4 3 Armadillo-like Adaptin_N PF01602.20 KOS18542.1 - 6.8e-05 21.6 0.0 0.0016 17.1 0.0 2.5 1 1 1 2 2 2 1 Adaptin N terminal region V-ATPase_H_C PF11698.8 KOS18542.1 - 0.00024 21.2 0.0 4.9 7.3 0.0 4.3 3 2 2 5 5 5 1 V-ATPase subunit H HEAT_PBS PF03130.16 KOS18542.1 - 0.0016 18.9 0.2 1.7 9.6 0.0 4.3 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Cnd1 PF12717.7 KOS18542.1 - 0.0048 17.0 0.0 4.6 7.3 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Glycos_trans_3N PF02885.17 KOS18542.1 - 0.057 13.3 0.0 7.2 6.5 0.0 3.3 3 0 0 3 3 3 0 Glycosyl transferase family, helical bundle domain RICTOR_V PF14668.6 KOS18542.1 - 0.071 13.4 5.8 3.4 8.0 0.1 4.9 4 2 2 6 6 6 0 Rapamycin-insensitive companion of mTOR, domain 5 AT_hook PF02178.19 KOS18543.1 - 0.31 11.1 40.0 1 9.5 5.5 4.9 4 0 0 4 4 4 0 AT hook motif zf-C2HE PF16278.5 KOS18544.1 - 1.6e-18 66.9 0.1 3.1e-18 66.0 0.1 1.5 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DcpS_C PF11969.8 KOS18544.1 - 6.7e-15 55.6 0.1 5e-07 30.2 0.3 2.2 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 KOS18544.1 - 3.3e-14 53.4 0.0 2.3e-13 50.7 0.0 2.0 1 1 0 1 1 1 1 HIT domain Las1 PF04031.13 KOS18545.1 - 1.2e-49 168.3 2.4 1.9e-49 167.7 2.4 1.3 1 0 0 1 1 1 1 Las1-like GEN1_C PF18380.1 KOS18545.1 - 0.067 14.1 4.4 0.2 12.5 4.4 1.8 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain DUF4746 PF15928.5 KOS18545.1 - 0.21 10.9 7.4 0.36 10.2 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_3_Rpc31 PF11705.8 KOS18545.1 - 1.1 9.5 12.7 1.6 8.9 12.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 KOS18545.1 - 1.1 7.4 9.3 1.7 6.8 9.3 1.2 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 KOS18545.1 - 2 7.5 4.3 3.1 6.9 4.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.9 KOS18545.1 - 3.5 6.7 11.2 5.5 6.0 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Memo PF01875.17 KOS18546.1 - 4.1e-61 206.5 0.0 5e-61 206.2 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein Polyketide_cyc2 PF10604.9 KOS18546.1 - 0.18 12.1 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport KTI12 PF08433.10 KOS18547.1 - 2.4e-66 224.0 0.0 3.5e-66 223.4 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 KOS18547.1 - 0.00032 20.9 0.2 0.00059 20.0 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOS18547.1 - 0.0038 17.8 0.0 0.0074 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain 6PF2K PF01591.18 KOS18547.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_22 PF13401.6 KOS18547.1 - 0.059 13.6 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS18547.1 - 0.067 13.6 0.4 0.12 12.7 0.4 1.6 1 1 0 1 1 1 0 AAA ATPase domain GT-D PF08759.11 KOS18547.1 - 0.087 12.5 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase GT-D fold DRMBL PF07522.14 KOS18548.1 - 1.4e-34 118.6 0.0 2.6e-34 117.7 0.0 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 KOS18548.1 - 1.7e-05 24.5 0.0 3.2e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain LSM PF01423.22 KOS18551.1 - 1.1e-17 63.5 0.4 1.3e-17 63.2 0.4 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS18551.1 - 0.0015 18.7 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain Hfq PF17209.3 KOS18551.1 - 0.0039 16.8 0.0 0.0057 16.3 0.0 1.3 1 0 0 1 1 1 1 Hfq protein AEP1 PF17049.5 KOS18551.1 - 0.011 14.9 0.1 0.011 14.9 0.1 1.1 1 0 0 1 1 1 0 ATPase expression protein 1 ThiF PF00899.21 KOS18552.1 - 1.9e-35 122.4 0.1 2.7e-35 121.9 0.1 1.1 1 0 0 1 1 1 1 ThiF family E2_bind PF08825.10 KOS18552.1 - 8.1e-31 106.0 0.2 1.3e-30 105.4 0.2 1.3 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 KOS18552.1 - 0.013 16.1 0.0 0.043 14.4 0.0 1.9 2 0 0 2 2 2 0 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain E1_UFD PF09358.10 KOS18552.1 - 0.036 14.7 0.0 0.13 13.0 0.0 1.9 1 0 0 1 1 1 0 Ubiquitin fold domain Rad50_zn_hook PF04423.14 KOS18552.1 - 0.24 11.3 1.0 0.58 10.0 1.0 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif RNA_pol_A_bac PF01000.26 KOS18553.1 - 1.1e-24 87.0 0.0 2.6e-24 85.8 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOS18553.1 - 1.5e-21 75.5 0.0 2e-21 75.2 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Pkinase PF00069.25 KOS18554.1 - 2.8e-54 184.3 0.0 3.7e-54 183.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18554.1 - 5.4e-41 140.6 0.0 8e-41 140.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS18554.1 - 0.00025 21.0 3.4 0.027 14.4 0.3 3.4 2 2 1 3 3 3 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS18554.1 - 0.001 18.1 0.0 0.027 13.4 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 KOS18554.1 - 0.0031 16.9 0.0 0.0094 15.3 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOS18554.1 - 0.0042 16.5 0.0 0.0092 15.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOS18554.1 - 0.014 14.2 0.0 0.12 11.1 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase ABC1 PF03109.16 KOS18554.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 ABC1 family RIO1 PF01163.22 KOS18554.1 - 0.14 11.7 0.1 0.45 10.1 0.0 1.8 2 1 0 2 2 2 0 RIO1 family Telomere_reg-2 PF10193.9 KOS18555.1 - 8.1e-10 39.1 0.0 1.9e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Telomere length regulation protein WD40 PF00400.32 KOS18556.1 - 2e-51 170.8 27.4 1e-05 26.2 0.2 12.6 12 1 0 12 12 12 10 WD domain, G-beta repeat Utp12 PF04003.12 KOS18556.1 - 1.5e-18 67.1 0.0 2.8e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KOS18556.1 - 5.1e-18 65.2 4.5 0.016 15.5 0.0 8.9 7 3 3 10 10 10 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS18556.1 - 6.1e-07 28.5 1.2 0.64 8.6 0.0 5.5 5 1 0 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 KOS18556.1 - 2.6e-05 23.7 0.0 1 8.6 0.0 3.5 3 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 KOS18556.1 - 0.00015 20.8 0.1 3.3 6.6 0.0 5.0 4 2 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 KOS18556.1 - 0.00047 19.0 0.3 1.4 7.5 0.0 4.4 3 1 1 4 4 4 1 Nup133 N terminal like Frtz PF11768.8 KOS18556.1 - 0.024 13.0 0.0 0.61 8.3 0.0 2.2 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz eIF2A PF08662.11 KOS18556.1 - 0.082 12.8 0.0 2.1 8.2 0.0 3.2 4 1 1 5 5 5 0 Eukaryotic translation initiation factor eIF2A Ala_racemase_C PF00842.21 KOS18556.1 - 0.11 12.3 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 Alanine racemase, C-terminal domain Lipoxygenase PF00305.19 KOS18557.1 - 1e-17 63.8 0.0 1.5e-17 63.3 0.0 1.1 1 0 0 1 1 1 1 Lipoxygenase SPX PF03105.19 KOS18558.1 - 0.01 15.8 7.6 0.017 15.0 7.6 1.4 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 KOS18558.1 - 2.3 7.0 5.3 3.2 6.5 5.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pyridoxal_deC PF00282.19 KOS18559.1 - 4.9e-16 58.4 0.0 7.2e-16 57.9 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_5 PF00266.19 KOS18559.1 - 4.6e-05 22.5 0.0 8.7e-05 21.6 0.0 1.4 1 1 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS18559.1 - 0.00021 20.7 0.0 0.00031 20.2 0.0 1.1 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_hydro_26 PF02156.15 KOS18559.1 - 0.19 11.1 0.4 0.32 10.4 0.4 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 26 BCDHK_Adom3 PF10436.9 KOS18560.1 - 6.8e-76 253.6 0.0 1.7e-75 252.3 0.0 1.6 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOS18560.1 - 6.1e-10 39.6 0.0 1.3e-09 38.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOS18560.1 - 0.048 13.5 0.0 0.085 12.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NBP1 PF08537.10 KOS18561.1 - 0.029 13.8 8.4 0.019 14.4 2.9 2.2 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 DUF3223 PF11523.8 KOS18561.1 - 0.034 15.0 0.1 0.092 13.6 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3223) HMMR_N PF15905.5 KOS18561.1 - 0.14 11.6 6.4 0.3 10.5 6.4 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF2203 PF09969.9 KOS18561.1 - 0.67 10.7 7.1 0.27 12.0 3.8 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Cnn_1N PF07989.11 KOS18561.1 - 1.4 9.1 8.2 4.8 7.4 1.8 2.8 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Seryl_tRNA_N PF02403.22 KOS18561.1 - 2.1 8.6 7.1 1.4 9.2 4.0 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 KOS18561.1 - 2.5 8.3 11.4 0.41 10.8 7.3 1.8 2 0 0 2 2 2 0 Tropomyosin like LRS4 PF10422.9 KOS18561.1 - 6.2 6.3 10.5 0.12 11.9 3.0 1.9 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 DUF4094 PF13334.6 KOS18561.1 - 7.8 7.0 6.4 2.4 8.6 1.6 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) DUF5320 PF17253.2 KOS18561.1 - 8.7 7.5 6.8 35 5.6 0.6 3.3 3 1 0 4 4 4 0 Family of unknown function (DUF5320) DUF1771 PF08590.10 KOS18562.1 - 1.3e-22 80.0 12.4 2.1e-22 79.3 12.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 KOS18562.1 - 5.7e-10 39.4 0.5 1.2e-09 38.4 0.5 1.6 1 0 0 1 1 1 1 Smr domain RHD_DNA_bind PF00554.22 KOS18562.1 - 0.0096 15.9 0.5 0.016 15.1 0.5 1.3 1 0 0 1 1 1 1 Rel homology DNA-binding domain Phage_Mu_F PF04233.14 KOS18562.1 - 0.11 13.2 2.0 0.3 11.8 2.0 2.0 1 1 0 1 1 1 0 Phage Mu protein F like protein DUF4407 PF14362.6 KOS18562.1 - 0.12 11.7 3.6 0.15 11.4 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OmpH PF03938.14 KOS18562.1 - 0.34 11.2 2.0 0.35 11.2 1.2 1.5 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Stc1 PF12898.7 KOS18563.1 - 2.6e-20 72.7 2.0 6.9e-20 71.4 2.0 1.7 1 0 0 1 1 1 1 Stc1 domain PCSK9_C1 PF18459.1 KOS18563.1 - 0.01 16.0 1.6 0.17 12.0 0.0 3.0 2 1 0 3 3 3 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain Oxidored_q2 PF00420.24 KOS18564.1 - 4.6 6.9 10.2 0.099 12.3 2.8 2.1 2 0 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Fungal_trans_2 PF11951.8 KOS18565.1 - 1.5e-08 33.9 0.2 1.6e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Glyco_hydro_16 PF00722.21 KOS18566.1 - 1.2e-12 47.7 0.1 1.9e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TraG-D_C PF12696.7 KOS18566.1 - 0.15 12.0 0.0 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG Lung_7-TM_R PF06814.13 KOS18567.1 - 4.3e-40 137.8 16.1 1.1e-39 136.5 12.4 2.0 1 1 1 2 2 2 2 Lung seven transmembrane receptor AgrB PF04647.15 KOS18567.1 - 1.7 7.9 8.2 0.22 10.8 3.5 1.8 2 0 0 2 2 2 0 Accessory gene regulator B DUF4131 PF13567.6 KOS18567.1 - 2.1 8.0 8.5 1.2 8.8 2.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4131) Pro_isomerase PF00160.21 KOS18568.1 - 6.5e-50 169.5 0.1 1.1e-49 168.8 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.15 KOS18568.1 - 0.00045 20.3 0.1 0.0042 17.2 0.0 2.6 2 0 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 KOS18568.1 - 0.0034 17.5 0.0 0.0081 16.3 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein RasGEF PF00617.19 KOS18569.1 - 1.2e-58 198.2 0.5 2.3e-58 197.3 0.5 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 KOS18569.1 - 1.5e-28 99.1 1.0 2.9e-28 98.2 1.0 1.5 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_1 PF00018.28 KOS18569.1 - 1.4e-15 56.6 0.1 3.5e-15 55.3 0.1 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS18569.1 - 2.7e-14 52.8 0.2 8e-14 51.2 0.2 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOS18569.1 - 2e-13 49.8 0.1 5.2e-13 48.5 0.1 1.8 1 0 0 1 1 1 1 Variant SH3 domain WW PF00397.26 KOS18569.1 - 0.082 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 WW domain Atrophin-1 PF03154.15 KOS18572.1 - 0.0025 16.2 13.9 0.0026 16.2 13.9 1.1 1 0 0 1 1 1 1 Atrophin-1 family Trypan_PARP PF05887.11 KOS18572.1 - 0.019 15.0 6.9 0.02 14.9 6.9 1.0 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SR-25 PF10500.9 KOS18572.1 - 0.057 13.0 11.2 0.059 13.0 11.2 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RRN9 PF10680.9 KOS18572.1 - 0.065 13.5 4.0 0.09 13.1 4.0 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor DUF2956 PF11169.8 KOS18572.1 - 0.17 12.1 9.0 0.18 12.0 9.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) AP-5_subunit_s1 PF15001.6 KOS18572.1 - 0.19 11.7 4.8 0.19 11.7 4.8 1.0 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 Vfa1 PF08432.10 KOS18572.1 - 0.23 11.8 13.5 0.23 11.8 13.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 KOS18572.1 - 0.29 10.9 7.2 0.28 10.9 7.2 1.0 1 0 0 1 1 1 0 Connexin RPN2_C PF18004.1 KOS18572.1 - 0.44 10.5 14.6 0.48 10.3 14.6 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNApol_Exo PF18136.1 KOS18572.1 - 0.74 8.9 8.3 0.78 8.8 8.3 1.0 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Sec62 PF03839.16 KOS18572.1 - 0.79 9.2 8.3 0.83 9.1 8.3 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RNA_pol_Rpc4 PF05132.14 KOS18572.1 - 0.88 10.0 7.6 0.91 9.9 7.6 1.0 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 KOS18572.1 - 0.89 8.7 6.5 0.85 8.8 6.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Ycf1 PF05758.12 KOS18572.1 - 0.99 7.2 8.0 0.9 7.3 8.0 1.0 1 0 0 1 1 1 0 Ycf1 ORC_WH_C PF18137.1 KOS18572.1 - 1.2 9.2 11.1 1.4 9.0 11.1 1.0 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Presenilin PF01080.17 KOS18572.1 - 1.2 7.8 5.6 1.1 7.9 5.6 1.0 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 KOS18572.1 - 1.3 9.1 8.5 1.3 9.1 8.5 1.0 1 0 0 1 1 1 0 E2F-associated phosphoprotein FAM176 PF14851.6 KOS18572.1 - 1.3 8.7 9.3 1.3 8.7 9.3 1.1 1 0 0 1 1 1 0 FAM176 family DUF853 PF05872.12 KOS18572.1 - 1.3 7.5 3.3 1.3 7.5 3.3 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) GNAT_acetyltr_2 PF13718.6 KOS18572.1 - 1.4 8.2 4.7 1.5 8.2 4.7 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 DUF4637 PF15470.6 KOS18572.1 - 1.8 8.3 11.5 1.9 8.2 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 KOS18572.1 - 1.9 6.7 10.4 1.8 6.8 10.4 1.0 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 KOS18572.1 - 1.9 8.7 8.5 1.9 8.6 8.5 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FPN1 PF06963.12 KOS18572.1 - 2 6.9 4.7 1.9 6.9 4.7 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) RR_TM4-6 PF06459.12 KOS18572.1 - 2.1 8.1 12.3 2 8.2 12.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RPA43_OB PF17875.1 KOS18572.1 - 2.4 8.8 8.0 2.4 8.8 8.0 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Folate_carrier PF01770.18 KOS18572.1 - 3.2 6.4 5.6 3 6.5 5.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier DUF3915 PF13054.6 KOS18572.1 - 3.2 7.7 15.9 6.9 6.7 15.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) NARP1 PF12569.8 KOS18572.1 - 3.4 6.4 12.5 3.2 6.6 12.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 AIF_C PF14721.6 KOS18572.1 - 3.6 7.9 7.0 4.1 7.8 7.0 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term EOS1 PF12326.8 KOS18572.1 - 3.7 7.5 5.1 3.8 7.4 5.1 1.0 1 0 0 1 1 1 0 N-glycosylation protein OATP PF03137.20 KOS18572.1 - 3.9 5.7 4.8 4 5.6 4.8 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 KOS18572.1 - 4 7.2 10.3 4.3 7.1 10.3 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Phage_Gp23 PF10669.9 KOS18572.1 - 4.2 7.7 16.0 5.8 7.3 16.0 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Paf1 PF03985.13 KOS18572.1 - 4.3 6.2 16.5 4.4 6.2 16.5 1.0 1 0 0 1 1 1 0 Paf1 MscS_TM PF12794.7 KOS18572.1 - 4.3 6.1 6.1 4.6 6.0 6.1 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 HA2 PF04408.23 KOS18572.1 - 4.6 7.6 7.3 4.8 7.5 7.3 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Auts2 PF15336.6 KOS18572.1 - 4.8 7.2 11.6 5 7.2 11.6 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein EIIBC-GUT_N PF03612.14 KOS18572.1 - 4.9 6.8 9.5 5.2 6.8 9.5 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2235 PF09994.9 KOS18572.1 - 5.4 6.3 8.8 5.8 6.2 8.8 1.0 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) FHIPEP PF00771.20 KOS18572.1 - 5.8 5.2 4.7 5.8 5.2 4.7 1.0 1 0 0 1 1 1 0 FHIPEP family Pox_P35 PF03213.14 KOS18572.1 - 7 5.8 5.7 7.2 5.7 5.7 1.0 1 0 0 1 1 1 0 Poxvirus P35 protein CLN3 PF02487.17 KOS18572.1 - 8.3 5.3 4.7 7.6 5.5 4.7 1.0 1 0 0 1 1 1 0 CLN3 protein zf-C2HC_2 PF13913.6 KOS18573.1 - 0.01 15.7 0.6 0.016 15.1 0.6 1.3 1 0 0 1 1 1 0 zinc-finger of a C2HC-type LsmAD PF06741.13 KOS18573.1 - 0.26 11.9 12.4 0.75 10.4 12.4 1.8 1 0 0 1 1 1 0 LsmAD domain DUF2828 PF11443.8 KOS18573.1 - 0.88 7.6 7.1 1.2 7.1 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Mito_carr PF00153.27 KOS18574.1 - 1.5e-42 143.4 1.5 1.8e-13 50.2 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein zf-C2H2_assoc PF16606.5 KOS18574.1 - 0.37 11.0 8.2 8 6.8 5.6 2.5 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers WW PF00397.26 KOS18575.1 - 9.2e-10 38.4 4.2 2.1e-09 37.3 4.2 1.6 1 0 0 1 1 1 1 WW domain WRW PF10206.9 KOS18575.1 - 0.015 15.7 0.5 0.028 14.8 0.5 1.4 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f RIX1 PF08167.12 KOS18576.1 - 8e-60 201.8 1.3 1.7e-59 200.8 1.3 1.6 1 0 0 1 1 1 1 rRNA processing/ribosome biogenesis MLTR_LBD PF17765.1 KOS18576.1 - 0.032 14.3 0.9 0.14 12.3 0.1 2.4 2 0 0 2 2 2 0 MmyB-like transcription regulator ligand binding domain DUF3446 PF11928.8 KOS18576.1 - 9.5 6.6 10.3 4.5 7.6 4.6 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain TPR_19 PF14559.6 KOS18577.1 - 8.9e-05 22.9 4.0 0.14 12.7 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS18577.1 - 0.0001 22.2 4.1 0.17 12.2 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS18577.1 - 0.00047 20.4 2.7 0.25 11.8 0.1 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS18577.1 - 0.0036 18.0 32.2 0.13 13.2 0.3 8.8 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18577.1 - 0.011 15.8 21.4 0.12 12.5 0.1 7.1 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18577.1 - 0.014 16.0 18.5 13 6.5 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOS18577.1 - 0.14 12.0 12.2 6.6 6.7 0.0 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOS18577.1 - 0.84 9.8 10.0 14 6.0 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOS18577.1 - 5.8 7.9 13.3 20 6.2 0.1 5.1 4 0 0 4 4 4 0 Tetratricopeptide repeat RTA1 PF04479.13 KOS18578.1 - 4.2e-58 196.4 7.8 1.5e-57 194.6 7.8 1.8 1 1 0 1 1 1 1 RTA1 like protein DUF3488 PF11992.8 KOS18578.1 - 2.9 6.8 7.8 0.34 9.8 1.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) PPP4R2 PF09184.11 KOS18579.1 - 0.02 14.5 5.6 0.027 14.1 5.6 1.2 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 KOS18579.1 - 0.16 11.6 14.7 0.3 10.8 14.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 KOS18579.1 - 0.65 9.3 13.0 0.93 8.8 13.0 1.2 1 0 0 1 1 1 0 NOA36 protein bZIP_1 PF00170.21 KOS18581.1 - 1.7e-06 28.1 8.4 2.4e-06 27.5 8.4 1.3 1 0 0 1 1 1 1 bZIP transcription factor GvpL_GvpF PF06386.11 KOS18581.1 - 0.016 15.1 2.8 0.018 15.0 2.8 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF5595 PF18077.1 KOS18581.1 - 0.048 13.7 0.2 0.075 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Histone_HNS PF00816.21 KOS18581.1 - 0.051 14.4 3.4 0.092 13.6 3.4 1.4 1 0 0 1 1 1 0 H-NS histone family ComFB PF10719.9 KOS18581.1 - 0.061 13.4 1.6 0.11 12.6 1.6 1.4 1 0 0 1 1 1 0 Late competence development protein ComFB HSCB_C PF07743.13 KOS18581.1 - 0.22 12.1 3.9 0.36 11.4 3.9 1.3 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain DUF2852 PF11014.8 KOS18581.1 - 0.38 10.9 4.5 1.2 9.3 4.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) bZIP_2 PF07716.15 KOS18581.1 - 0.64 10.1 11.7 0.43 10.7 9.3 1.9 1 1 1 2 2 2 0 Basic region leucine zipper Glyco_hydro_16 PF00722.21 KOS18582.1 - 1.2e-07 31.4 0.1 1.8e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 LPAM_1 PF08139.12 KOS18582.1 - 0.85 10.2 2.7 1.8 9.2 2.7 1.5 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site Xpo1 PF08389.12 KOS18584.1 - 7.1e-35 120.3 0.1 1.9e-33 115.6 0.0 3.3 3 0 0 3 3 3 1 Exportin 1-like protein HEAT PF02985.22 KOS18584.1 - 0.0068 16.6 0.0 6.1 7.4 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat Mce4_CUP1 PF11887.8 KOS18584.1 - 0.014 14.9 0.4 0.025 14.0 0.4 1.3 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative CPL PF08144.11 KOS18584.1 - 0.033 14.6 0.0 7 7.0 0.0 2.9 2 1 0 2 2 2 0 CPL (NUC119) domain DUF4844 PF16133.5 KOS18584.1 - 0.043 14.4 0.9 2.3 8.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4844) CNOT11 PF10155.9 KOS18584.1 - 0.047 13.8 3.8 3.8 7.7 0.6 3.8 3 0 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 LEA_6 PF10714.9 KOS18584.1 - 0.2 11.7 0.1 0.39 10.8 0.1 1.4 1 0 0 1 1 1 0 Late embryogenesis abundant protein 18 Prefoldin_2 PF01920.20 KOS18584.1 - 0.75 9.8 6.6 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 Prefoldin subunit Gtr1_RagA PF04670.12 KOS18585.1 - 2.4e-51 174.3 0.3 3e-51 174.0 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region OGG_N PF07934.12 KOS18585.1 - 0.079 13.1 0.0 0.13 12.3 0.0 1.6 1 1 0 1 1 1 0 8-oxoguanine DNA glycosylase, N-terminal domain VHS PF00790.19 KOS18586.1 - 3.1e-05 23.9 0.0 0.00056 19.8 0.0 2.4 2 0 0 2 2 2 1 VHS domain CTD_bind PF04818.13 KOS18586.1 - 5.4e-05 23.9 0.0 0.00015 22.6 0.0 1.8 1 0 0 1 1 1 1 RNA polymerase II-binding domain. CFIA_Pcf11 PF11526.8 KOS18586.1 - 0.00016 22.1 0.1 0.00016 22.1 0.1 2.8 3 0 0 3 3 3 1 Subunit of cleavage factor IA Pcf11 Spt20 PF12090.8 KOS18586.1 - 1.9 8.1 15.4 4.2 6.9 15.4 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KOS18586.1 - 5.4 6.9 32.2 4.8 7.1 23.3 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit Aconitase PF00330.20 KOS18587.1 - 1.4e-111 373.8 0.1 1.2e-110 370.7 0.1 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOS18587.1 - 2.9e-22 79.4 0.0 5.3e-22 78.6 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain MCM PF00493.23 KOS18587.1 - 0.21 10.6 1.1 0.38 9.8 0.2 1.8 2 0 0 2 2 2 0 MCM P-loop domain ANAPC4 PF12896.7 KOS18588.1 - 2.3e-64 216.7 0.0 3.2e-64 216.2 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4_WD40 PF12894.7 KOS18588.1 - 5.2e-12 45.9 0.0 5.3e-11 42.7 0.0 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4140 PF13600.6 KOS18588.1 - 0.044 14.2 0.0 0.14 12.6 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) CPSF_A PF03178.15 KOS18588.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 CPSF A subunit region Ge1_WD40 PF16529.5 KOS18588.1 - 0.15 11.0 0.0 3.3 6.6 0.0 2.1 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 KOS18588.1 - 1.7 9.7 4.6 1.8 9.6 0.0 3.4 5 0 0 5 5 5 0 WD domain, G-beta repeat DUF2264 PF10022.9 KOS18589.1 - 3.2e-117 391.6 0.4 3.9e-117 391.3 0.4 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) Glyco_hydro_88 PF07470.13 KOS18590.1 - 5.2e-11 42.2 0.3 7.8e-11 41.6 0.3 1.3 1 0 0 1 1 1 1 Glycosyl Hydrolase Family 88 Fungal_trans PF04082.18 KOS18591.1 - 3.4e-09 36.1 0.1 7.2e-09 35.1 0.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS18591.1 - 8.5e-09 35.4 11.5 1.6e-08 34.5 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CENP-B_dimeris PF09026.10 KOS18591.1 - 0.031 14.7 1.1 0.064 13.7 1.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 KOS18591.1 - 0.32 10.7 3.0 0.53 10.0 3.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sugar_tr PF00083.24 KOS18592.1 - 1e-73 248.8 20.2 1.3e-73 248.5 20.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS18592.1 - 2.3e-31 109.0 44.6 2.7e-26 92.4 26.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF4118 PF13493.6 KOS18592.1 - 1.7 8.5 12.3 0.41 10.4 0.5 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4118) Transp_cyt_pur PF02133.15 KOS18593.1 - 3.1e-21 75.7 34.6 9.3e-21 74.1 34.6 1.7 1 1 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin UPF0139 PF03669.13 KOS18593.1 - 0.16 11.8 0.2 0.52 10.2 0.2 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0139) Alginate_lyase PF05426.12 KOS18594.1 - 1.1e-77 261.3 0.0 1.6e-77 260.8 0.0 1.2 1 0 0 1 1 1 1 Alginate lyase Alpha-amylase_C PF02806.18 KOS18595.1 - 1.4e-27 96.0 0.0 2.4e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain AAA_2 PF07724.14 KOS18596.1 - 4.7e-33 114.7 0.0 9e-33 113.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 KOS18596.1 - 1.7e-12 47.9 0.0 2.8e-12 47.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KOS18596.1 - 3.8e-09 36.5 0.0 8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein MCM PF00493.23 KOS18596.1 - 8.4e-06 25.0 0.0 1.3e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain AAA_22 PF13401.6 KOS18596.1 - 1.2e-05 25.6 0.2 9e-05 22.8 0.2 2.3 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS18596.1 - 1.4e-05 25.1 0.0 2.9e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOS18596.1 - 0.0003 21.2 0.3 0.0016 18.9 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 KOS18596.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 KOS18596.1 - 0.0053 16.8 0.0 0.0096 16.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOS18596.1 - 0.012 14.9 0.0 0.38 10.1 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 KOS18596.1 - 0.027 14.2 0.0 0.19 11.5 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 KOS18596.1 - 0.032 14.7 0.0 0.053 14.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 KOS18596.1 - 0.037 13.7 0.0 0.069 12.9 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 KOS18596.1 - 0.038 13.7 0.0 0.056 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 KOS18596.1 - 0.062 13.1 0.1 5 6.9 0.0 2.8 3 0 0 3 3 3 0 DEAD/DEAH box helicase T2SSE PF00437.20 KOS18596.1 - 0.069 12.2 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TniB PF05621.11 KOS18596.1 - 0.078 12.4 0.0 0.4 10.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 KOS18596.1 - 0.081 12.3 0.0 0.18 11.1 0.0 1.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family STN PF07660.14 KOS18596.1 - 0.11 12.4 0.1 7.4 6.5 0.1 2.5 2 0 0 2 2 2 0 Secretin and TonB N terminus short domain NACHT PF05729.12 KOS18596.1 - 0.12 12.3 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 KOS18596.1 - 0.16 12.5 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_21 PF13304.6 KOS18596.1 - 0.21 11.4 0.0 0.75 9.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system CBM_48 PF02922.18 KOS18597.1 - 5.6e-17 61.9 0.0 1.4e-16 60.6 0.0 1.7 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 KOS18597.1 - 8.1e-16 58.5 0.4 1.9e-11 44.1 0.2 2.3 1 1 1 2 2 2 2 Alpha amylase, catalytic domain Fungal_trans PF04082.18 KOS18598.1 - 6.7e-11 41.7 0.8 1.1e-10 41.0 0.8 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain MOFRL PF05161.13 KOS18598.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 MOFRL family COX4 PF02936.14 KOS18599.1 - 6.7e-46 155.7 0.1 7.8e-46 155.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV DUF2407_C PF13373.6 KOS18599.1 - 0.052 13.7 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 DUF2407 C-terminal domain DUF1104 PF06518.11 KOS18599.1 - 0.15 12.5 0.1 0.54 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) TPT PF03151.16 KOS18600.1 - 1.8e-59 201.5 8.1 2.2e-59 201.2 8.1 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOS18600.1 - 8e-11 42.3 26.6 2e-06 28.0 9.0 3.0 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOS18600.1 - 8.5e-07 28.5 11.5 3.6e-06 26.4 11.5 1.8 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 KOS18600.1 - 0.0032 16.7 7.9 0.0038 16.5 6.6 1.8 1 1 0 1 1 1 1 Purine nucleobase transmembrane transport ORC5_C PF14630.6 KOS18601.1 - 1.4e-73 247.9 0.0 2.2e-73 247.2 0.0 1.3 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus Mus7 PF09462.10 KOS18601.1 - 1.7e-06 27.2 0.1 2.2e-06 26.9 0.1 1.1 1 0 0 1 1 1 1 Mus7/MMS22 family AAA_16 PF13191.6 KOS18601.1 - 0.00056 20.3 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain Ald_deCOase PF11266.8 KOS18601.1 - 0.0027 17.5 0.0 0.15 11.8 0.0 2.2 2 0 0 2 2 2 1 Long-chain fatty aldehyde decarbonylase AAA_22 PF13401.6 KOS18601.1 - 0.0041 17.4 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 KOS18602.1 - 2.4e-38 131.5 0.0 4.6e-38 130.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS18602.1 - 6.9e-09 35.4 0.3 2.1e-08 33.8 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 KOS18602.1 - 6.6e-06 26.0 0.0 1.9e-05 24.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOS18602.1 - 2.8e-05 24.4 1.2 0.039 14.2 0.1 3.3 2 1 1 3 3 3 1 AAA domain AAA_16 PF13191.6 KOS18602.1 - 6.9e-05 23.3 0.1 0.0034 17.8 0.0 2.8 1 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 KOS18602.1 - 0.00026 21.0 0.0 0.00056 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 KOS18602.1 - 0.00085 19.3 0.5 1 9.2 0.1 3.0 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_5 PF07728.14 KOS18602.1 - 0.003 17.5 0.1 0.0096 15.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOS18602.1 - 0.0072 16.5 0.0 0.02 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOS18602.1 - 0.0095 15.3 0.1 0.02 14.2 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 KOS18602.1 - 0.011 15.4 0.0 0.025 14.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KOS18602.1 - 0.015 14.7 0.0 0.52 9.7 0.0 2.3 1 1 1 2 2 2 0 Bacterial TniB protein TIP49 PF06068.13 KOS18602.1 - 0.015 14.5 0.1 0.037 13.2 0.1 1.6 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 KOS18602.1 - 0.016 15.7 0.0 0.044 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 KOS18602.1 - 0.018 14.7 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 KOS18602.1 - 0.028 14.0 0.3 0.65 9.5 0.1 2.4 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOS18602.1 - 0.04 14.3 0.2 0.14 12.5 0.0 2.0 2 0 0 2 2 2 0 RNA helicase Imm70 PF15601.6 KOS18602.1 - 0.1 12.1 0.0 2.1 7.9 0.0 2.5 2 0 0 2 2 2 0 Immunity protein 70 DASH_Dad2 PF08654.10 KOS18602.1 - 0.13 12.7 0.2 8.2 6.9 0.0 2.6 2 0 0 2 2 2 0 DASH complex subunit Dad2 NACHT PF05729.12 KOS18602.1 - 0.18 11.7 0.5 0.49 10.3 0.1 2.0 2 0 0 2 2 2 0 NACHT domain Hydin_ADK PF17213.3 KOS18602.1 - 0.53 10.5 2.5 5.5 7.2 0.1 2.7 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain PH_TFIIH PF08567.11 KOS18603.1 - 3.6e-27 94.5 0.0 1.3e-26 92.7 0.0 2.0 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain BSD PF03909.17 KOS18603.1 - 1.2e-25 89.2 2.7 1.4e-12 47.4 0.0 2.9 3 0 0 3 3 3 2 BSD domain DHC_N1 PF08385.12 KOS18603.1 - 0.005 15.5 0.5 0.37 9.4 0.2 2.2 2 0 0 2 2 2 2 Dynein heavy chain, N-terminal region 1 AD PF09793.9 KOS18603.1 - 0.19 11.9 1.0 0.89 9.7 0.9 2.1 2 0 0 2 2 2 0 Anticodon-binding domain DUF2428 PF10350.9 KOS18604.1 - 9.4e-63 212.0 0.1 1.5e-62 211.4 0.1 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 KOS18604.1 - 0.082 13.2 15.1 0.36 11.2 0.1 6.7 8 0 0 8 8 8 0 HEAT repeat Ribosomal_L1 PF00687.21 KOS18605.1 - 5.5e-46 156.9 0.1 6.6e-46 156.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family EST1_DNA_bind PF10373.9 KOS18606.1 - 3.1e-46 158.1 0.2 5.6e-46 157.3 0.2 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 KOS18606.1 - 2.6e-20 73.4 0.2 9.1e-20 71.7 0.2 1.9 1 0 0 1 1 1 1 Telomerase activating protein Est1 DUF3074 PF11274.8 KOS18607.1 - 1.2e-56 191.6 0.9 3.1e-55 187.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3074) Caldesmon PF02029.15 KOS18607.1 - 0.0031 16.3 24.1 0.0052 15.6 24.1 1.3 1 0 0 1 1 1 1 Caldesmon DUF4407 PF14362.6 KOS18607.1 - 7 5.9 19.4 11 5.2 19.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arf PF00025.21 KOS18608.1 - 5.6e-74 247.4 0.1 6.7e-74 247.1 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOS18608.1 - 9.2e-15 54.9 0.0 1.2e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOS18608.1 - 5e-13 48.9 0.0 5.9e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 KOS18608.1 - 6.6e-12 45.3 0.4 9.6e-08 31.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KOS18608.1 - 8.8e-12 44.9 0.0 1e-11 44.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 KOS18608.1 - 1.8e-08 34.0 0.0 2.3e-08 33.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS18608.1 - 7.4e-07 29.2 0.0 1.2e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS18608.1 - 0.00012 21.7 0.0 0.0098 15.4 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 KOS18608.1 - 0.02 14.4 0.8 0.058 12.9 0.8 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B AAA_18 PF13238.6 KOS18608.1 - 0.12 12.9 0.1 0.21 12.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain NERD PF08378.11 KOS18609.1 - 0.005 17.3 0.6 0.14 12.7 0.1 2.1 2 0 0 2 2 2 2 Nuclease-related domain Skp1 PF01466.19 KOS18611.1 - 2.5e-28 98.0 0.5 4.7e-28 97.1 0.5 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 KOS18611.1 - 5.8e-20 71.2 0.1 1.5e-19 69.9 0.1 1.8 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain Trnau1ap PF17654.1 KOS18611.1 - 0.14 13.0 1.3 0.41 11.5 1.3 1.8 1 1 0 1 1 1 0 Selenocysteine tRNA 1 associated proteins GMC_oxred_N PF00732.19 KOS18612.1 - 5.9e-41 140.8 0.1 8.3e-41 140.3 0.1 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS18612.1 - 4e-25 89.0 0.0 9.1e-25 87.9 0.0 1.6 1 0 0 1 1 1 1 GMC oxidoreductase Pyr_redox_2 PF07992.14 KOS18612.1 - 1.5e-09 37.6 0.1 1.4e-08 34.4 0.0 2.3 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS18612.1 - 4.2e-09 36.0 0.6 8e-09 35.1 0.6 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOS18612.1 - 8.8e-06 25.9 0.2 4.2e-05 23.7 0.1 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOS18612.1 - 1.4e-05 24.6 0.1 2.1e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 KOS18612.1 - 4.5e-05 23.0 0.1 0.00013 21.5 0.1 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS18612.1 - 7.1e-05 21.7 0.1 0.00014 20.7 0.1 1.4 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 KOS18612.1 - 0.0004 20.1 2.8 0.0053 16.4 0.4 3.1 3 1 1 4 4 4 1 FAD dependent oxidoreductase Thi4 PF01946.17 KOS18612.1 - 0.00076 18.8 0.1 0.0015 17.8 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 KOS18612.1 - 0.0032 16.8 0.1 0.028 13.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOS18612.1 - 0.005 16.0 0.4 0.051 12.6 0.1 2.0 2 0 0 2 2 2 1 Glucose inhibited division protein A Pyr_redox PF00070.27 KOS18612.1 - 0.016 15.8 0.0 0.051 14.1 0.0 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOS18612.1 - 0.061 12.4 0.1 0.12 11.4 0.1 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein PDEase_I PF00233.19 KOS18613.1 - 4.8e-20 72.3 2.1 1.3e-14 54.5 0.0 2.2 1 1 1 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GMC_oxred_N PF00732.19 KOS18614.1 - 2.8e-55 187.8 0.0 3.7e-55 187.4 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS18614.1 - 5.9e-31 107.9 0.3 1.1e-30 107.1 0.3 1.5 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 KOS18614.1 - 0.013 14.6 0.1 0.025 13.7 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_binding_2 PF00890.24 KOS18614.1 - 0.014 14.5 0.6 1.9 7.5 0.0 2.3 2 0 0 2 2 2 0 FAD binding domain Thi4 PF01946.17 KOS18614.1 - 0.13 11.5 0.1 0.25 10.5 0.1 1.4 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 KOS18614.1 - 0.2 10.5 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase NAD_binding_8 PF13450.6 KOS18614.1 - 0.43 10.9 3.3 0.91 9.8 0.4 2.9 3 1 1 4 4 4 0 NAD(P)-binding Rossmann-like domain MFS_1 PF07690.16 KOS18615.1 - 1e-23 83.9 53.6 1.3e-21 76.9 42.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 KOS18615.1 - 0.11 11.7 34.2 0.15 11.3 34.2 1.1 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB Coiled PF05710.12 KOS18616.1 - 5.7 7.8 9.4 1.5 9.7 3.2 2.8 3 0 0 3 3 3 0 Coiled coil MFS_1 PF07690.16 KOS18617.1 - 4.5e-30 104.8 33.8 4.5e-30 104.8 33.8 1.6 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS18617.1 - 0.011 14.6 5.0 0.047 12.5 3.1 2.5 3 0 0 3 3 3 0 MFS_1 like family Ribosomal_L4 PF00573.22 KOS18618.1 - 1.6e-36 125.8 0.2 2.3e-36 125.3 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 KOS18618.1 - 2.8e-26 91.4 1.8 2.8e-26 91.4 1.8 1.7 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain PGA2 PF07543.12 KOS18619.1 - 6.9e-38 129.7 2.2 8.4e-38 129.5 2.2 1.1 1 0 0 1 1 1 1 Protein trafficking PGA2 LdpA_C PF12617.8 KOS18619.1 - 0.032 13.8 0.1 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Iron-Sulfur binding protein C terminal GvpK PF05121.12 KOS18619.1 - 0.067 13.2 3.1 0.067 13.2 3.1 2.2 2 1 0 2 2 2 0 Gas vesicle protein K DUF4428 PF14471.6 KOS18620.1 - 0.0087 16.0 0.2 1.4 8.9 0.0 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4428) zinc_ribbon_9 PF14369.6 KOS18620.1 - 0.079 13.2 0.5 20 5.5 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon zf-RING_4 PF14570.6 KOS18620.1 - 0.15 11.9 1.3 22 5.0 0.0 3.5 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-HYPF PF07503.12 KOS18620.1 - 1.9 8.4 5.2 2.6 7.9 0.1 3.1 3 0 0 3 3 3 0 HypF finger Malic_M PF03949.15 KOS18621.1 - 1e-89 300.2 0.0 3.9e-89 298.3 0.0 1.8 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 KOS18621.1 - 3.7e-70 235.4 0.0 5.3e-70 234.9 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain Fungal_trans PF04082.18 KOS18622.1 - 6e-30 104.2 0.1 1.8e-29 102.6 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain GAS2 PF02187.17 KOS18623.1 - 7.5e-07 29.2 0.1 1.7e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain Pox_Ag35 PF03286.14 KOS18623.1 - 0.0028 17.5 1.0 0.0028 17.5 1.0 2.5 1 1 0 2 2 2 1 Pox virus Ag35 surface protein Aa_trans PF01490.18 KOS18624.1 - 2.9e-67 227.1 20.0 3.8e-67 226.8 20.0 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PsaM PF07465.13 KOS18624.1 - 0.2 11.4 2.7 0.6 9.9 2.7 1.9 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) F-box PF00646.33 KOS18625.1 - 0.00086 19.1 0.1 0.0017 18.2 0.1 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS18625.1 - 0.0051 16.7 0.2 0.019 14.9 0.2 2.0 1 0 0 1 1 1 1 F-box-like DUF1690 PF07956.11 KOS18626.1 - 0.93 9.9 4.9 1.1 9.7 1.0 2.4 2 1 1 3 3 3 0 Protein of Unknown function (DUF1690) Ras PF00071.22 KOS18627.1 - 1e-54 184.5 0.0 1.2e-54 184.3 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS18627.1 - 4.7e-22 78.4 0.0 6.6e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS18627.1 - 2.1e-07 30.6 0.0 3.8e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS18627.1 - 0.0016 18.0 0.1 0.0043 16.6 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 KOS18627.1 - 0.0043 16.5 0.0 0.0056 16.1 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOS18627.1 - 0.011 15.0 0.0 0.014 14.7 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region NB-ARC PF00931.22 KOS18627.1 - 0.014 14.5 0.0 0.18 10.9 0.0 2.0 1 1 1 2 2 2 0 NB-ARC domain RRM_1 PF00076.22 KOS18628.1 - 2.7e-13 49.5 0.0 6.4e-13 48.3 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS18628.1 - 0.079 12.6 0.0 0.079 12.6 0.0 1.6 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) cobW PF02492.19 KOS18629.1 - 2.3e-33 115.2 0.0 3.4e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 KOS18629.1 - 9e-06 24.9 0.9 0.00014 20.9 0.9 2.0 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_23 PF13476.6 KOS18629.1 - 0.0038 17.8 0.0 0.0058 17.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 KOS18629.1 - 0.013 15.6 0.0 0.057 13.5 0.0 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_16 PF13191.6 KOS18629.1 - 0.047 14.1 0.0 0.06 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 KOS18629.1 - 0.18 11.6 0.0 0.39 10.4 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ResIII PF04851.15 KOS18629.1 - 0.19 11.7 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit GspL_C PF12693.7 KOS18630.1 - 0.87 9.4 4.1 1.9 8.3 0.3 2.4 2 1 0 2 2 2 0 GspL periplasmic domain GRAB PF10375.9 KOS18631.1 - 3e-09 36.4 0.1 5.7e-09 35.5 0.1 1.5 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Atg14 PF10186.9 KOS18631.1 - 0.00057 19.1 14.8 0.00057 19.1 14.8 3.2 1 1 2 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 T3SSipB PF16535.5 KOS18631.1 - 0.0009 19.7 6.5 0.0009 19.7 6.5 3.7 3 1 0 3 3 1 1 Type III cell invasion protein SipB Spc7 PF08317.11 KOS18631.1 - 0.0027 16.6 23.9 0.0027 16.6 23.9 2.9 1 1 1 2 2 2 1 Spc7 kinetochore protein DUF641 PF04859.12 KOS18631.1 - 0.007 16.7 31.5 0.061 13.7 2.4 3.7 3 1 0 3 3 3 2 Plant protein of unknown function (DUF641) ADIP PF11559.8 KOS18631.1 - 0.017 15.2 8.8 0.017 15.2 8.8 3.7 1 1 2 3 3 2 0 Afadin- and alpha -actinin-Binding NPV_P10 PF05531.12 KOS18631.1 - 0.018 15.5 14.2 0.14 12.6 1.1 4.2 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 KOS18631.1 - 0.024 14.7 3.8 0.024 14.7 3.8 4.8 6 1 0 6 6 4 0 bZIP transcription factor GAS PF13851.6 KOS18631.1 - 0.18 11.2 50.0 0.13 11.6 4.6 4.2 1 1 2 4 4 4 0 Growth-arrest specific micro-tubule binding Prominin PF05478.11 KOS18631.1 - 0.48 8.3 21.1 0.12 10.4 4.3 2.6 1 1 1 2 2 2 0 Prominin Golgin_A5 PF09787.9 KOS18631.1 - 0.5 9.8 52.1 0.015 14.8 16.8 3.9 1 1 3 4 4 4 0 Golgin subfamily A member 5 DUF1664 PF07889.12 KOS18631.1 - 0.54 10.3 25.9 0.066 13.3 3.4 4.2 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) OmpH PF03938.14 KOS18631.1 - 0.69 10.2 44.6 0.9 9.9 15.6 3.5 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Filament PF00038.21 KOS18631.1 - 0.71 9.4 49.2 0.028 14.0 16.1 3.1 1 1 0 2 2 2 0 Intermediate filament protein Baculo_PEP_C PF04513.12 KOS18631.1 - 0.76 9.8 13.5 2.7 8.1 1.7 3.4 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_MLP1_2 PF07926.12 KOS18631.1 - 0.94 9.5 64.8 0.064 13.3 11.2 5.4 3 2 2 5 5 4 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.6 KOS18631.1 - 1.2 9.1 53.5 0.042 13.9 22.8 3.7 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion HicB_lk_antitox PF15919.5 KOS18631.1 - 2.1 8.5 6.2 2.9 8.0 1.0 2.6 2 0 0 2 2 2 0 HicB_like antitoxin of bacterial toxin-antitoxin system FPP PF05911.11 KOS18631.1 - 2.8 6.0 47.1 0.021 13.0 22.7 2.2 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Spectrin PF00435.21 KOS18631.1 - 3.2 8.3 40.5 2.9 8.4 9.9 4.7 2 1 2 5 5 5 0 Spectrin repeat Fib_alpha PF08702.10 KOS18631.1 - 5.4 7.2 28.0 15 5.7 9.4 3.6 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family 4F5 PF04419.14 KOS18633.1 - 9.4e-05 23.2 25.9 0.0094 16.8 25.9 2.4 1 1 0 1 1 1 1 4F5 protein family DUF1778 PF08681.11 KOS18633.1 - 0.0015 18.4 2.6 0.0018 18.2 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1778) DUF4407 PF14362.6 KOS18633.1 - 2.8 7.2 7.2 3 7.1 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ELO PF01151.18 KOS18634.1 - 4.7e-62 209.7 20.8 5.6e-62 209.5 20.8 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family F-box-like PF12937.7 KOS18635.1 - 2.2e-06 27.4 0.1 4.6e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS18635.1 - 0.015 15.1 0.3 0.84 9.6 0.3 2.6 2 0 0 2 2 2 0 F-box domain SPT_ssu-like PF11779.8 KOS18636.1 - 1.9e-20 72.2 2.3 2.6e-20 71.8 2.3 1.2 1 0 0 1 1 1 1 Small subunit of serine palmitoyltransferase-like DUF2254 PF10011.9 KOS18636.1 - 0.04 12.8 0.1 0.047 12.5 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) RF-1 PF00472.20 KOS18637.1 - 6.5e-24 84.1 3.6 1.1e-23 83.3 3.6 1.4 1 0 0 1 1 1 1 RF-1 domain C_Hendra PF16821.5 KOS18637.1 - 0.87 9.4 4.0 0.28 11.0 0.2 1.8 1 1 1 2 2 2 0 C protein from hendra and measles viruses Urm1 PF09138.11 KOS18638.1 - 1.6e-26 92.5 0.0 1.8e-26 92.3 0.0 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 KOS18638.1 - 0.0014 19.3 0.0 0.0016 19.1 0.0 1.1 1 0 0 1 1 1 1 ThiS family WD40 PF00400.32 KOS18639.1 - 2.3e-30 104.2 24.5 0.0002 22.1 0.1 11.1 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18639.1 - 7.4e-08 32.6 0.2 1.8 8.9 0.0 6.1 5 3 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4596 PF15363.6 KOS18639.1 - 0.035 14.3 0.2 0.12 12.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4596) PD40 PF07676.12 KOS18639.1 - 0.15 12.0 0.6 26 4.9 0.1 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Mito_carr PF00153.27 KOS18640.1 - 3.8e-55 183.8 2.1 3.5e-18 65.3 0.0 3.1 2 1 1 3 3 3 3 Mitochondrial carrier protein Mito_fiss_reg PF05308.11 KOS18640.1 - 0.055 13.5 1.4 0.084 12.9 1.4 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator NeA_P2 PF12312.8 KOS18640.1 - 0.1 12.0 0.8 0.17 11.3 0.8 1.3 1 0 0 1 1 1 0 Nepovirus subgroup A polyprotein PRIMA1 PF16101.5 KOS18640.1 - 2.7 8.0 8.1 6.5 6.8 8.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 KOS18640.1 - 4.5 6.7 7.4 7 6.0 7.4 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal zf-C2H2 PF00096.26 KOS18641.1 - 1.4e-18 66.2 18.9 1.2e-05 25.5 0.7 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS18641.1 - 2.8e-14 52.8 18.0 2.4e-07 30.9 0.3 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS18641.1 - 3.1e-10 40.0 16.5 0.038 14.8 0.4 5.0 4 0 0 4 4 4 4 C2H2-type zinc finger zf-met PF12874.7 KOS18641.1 - 0.0011 19.2 9.4 0.55 10.7 0.2 5.0 4 0 0 4 4 4 2 Zinc-finger of C2H2 type Cdh1_DBD_1 PF18196.1 KOS18641.1 - 0.16 12.3 0.0 0.41 11.0 0.0 1.7 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 zf-C2H2_aberr PF17017.5 KOS18641.1 - 0.16 12.1 3.8 0.26 11.4 0.1 2.7 1 1 0 3 3 3 0 Aberrant zinc-finger CAML PF14963.6 KOS18641.1 - 0.27 11.3 1.7 3.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Calcium signal-modulating cyclophilin ligand zf-LYAR PF08790.11 KOS18641.1 - 0.58 10.1 5.5 4.7 7.2 0.4 3.9 4 0 0 4 4 4 0 LYAR-type C2HC zinc finger Cohesin_load PF10345.9 KOS18642.1 - 1e-119 400.7 3.9 1.4e-119 400.2 3.9 1.1 1 0 0 1 1 1 1 Cohesin loading factor TPR_19 PF14559.6 KOS18642.1 - 0.25 11.9 4.5 0.41 11.2 0.6 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18642.1 - 0.3 11.3 0.1 0.3 11.3 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOS18643.1 - 2.2e-32 110.7 0.0 8.4e-16 57.6 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS18643.1 - 0.01 15.5 0.0 0.1 12.2 0.0 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS18643.1 - 0.026 14.7 0.0 0.077 13.1 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif OB_RNB PF08206.11 KOS18643.1 - 0.15 11.8 0.8 11 5.7 0.1 2.5 2 0 0 2 2 2 0 Ribonuclease B OB domain adh_short_C2 PF13561.6 KOS18644.1 - 3e-25 89.1 0.1 3.6e-25 88.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS18644.1 - 8.4e-11 41.7 0.1 1.1e-10 41.4 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Flu_PB1 PF00602.17 KOS18644.1 - 0.27 9.3 0.0 0.3 9.2 0.0 1.0 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB1 His_Phos_2 PF00328.22 KOS18645.1 - 0.26 10.6 0.7 14 4.9 0.1 2.7 2 1 1 3 3 3 0 Histidine phosphatase superfamily (branch 2) 3-HAO PF06052.12 KOS18646.1 - 6.6e-59 197.9 0.0 1.3e-57 193.7 0.0 2.0 1 1 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 KOS18646.1 - 4.8e-08 32.6 0.0 7.1e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 KOS18646.1 - 4.2e-05 23.5 0.0 7.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 KOS18646.1 - 0.00052 19.6 0.0 0.00082 19.0 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.14 KOS18646.1 - 0.085 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_4 PF08007.12 KOS18646.1 - 0.16 11.4 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein Cupin_3 PF05899.12 KOS18646.1 - 0.17 11.6 0.1 0.42 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF861) FAA_hydrolase PF01557.18 KOS18647.1 - 7.7e-52 176.1 0.0 9e-52 175.9 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Cullin PF00888.22 KOS18648.1 - 8.7e-192 639.0 0.0 1.1e-191 638.7 0.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOS18648.1 - 1.7e-24 85.7 0.1 4e-24 84.4 0.1 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain NTase_sub_bind PF08780.11 KOS18648.1 - 0.092 12.7 0.2 1.4 8.9 0.1 2.9 2 0 0 2 2 2 0 Nucleotidyltransferase substrate binding protein like LSM PF01423.22 KOS18649.1 - 3.2e-18 65.2 0.0 4.1e-18 64.8 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS18649.1 - 0.00048 20.2 0.0 0.00066 19.8 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF5549 PF17703.1 KOS18649.1 - 0.054 13.1 0.6 0.067 12.8 0.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5549) MTS PF05175.14 KOS18650.1 - 0.0054 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain MinE PF03776.14 KOS18652.1 - 0.083 12.9 0.1 0.18 11.8 0.1 1.5 1 0 0 1 1 1 0 Septum formation topological specificity factor MinE PKD_channel PF08016.12 KOS18652.1 - 0.1 11.2 6.8 1.8 7.2 0.4 2.3 2 0 0 2 2 2 0 Polycystin cation channel APH PF01636.23 KOS18653.1 - 1.3e-44 153.0 1.6 2e-44 152.3 1.6 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KOS18653.1 - 0.00034 20.0 0.0 0.00082 18.8 0.0 1.5 2 0 0 2 2 2 1 Ecdysteroid kinase Choline_kinase PF01633.20 KOS18653.1 - 0.0012 18.5 0.0 0.0019 17.8 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Fructosamin_kin PF03881.14 KOS18653.1 - 0.0051 16.1 0.0 0.062 12.5 0.0 2.1 1 1 0 1 1 1 1 Fructosamine kinase Kdo PF06293.14 KOS18653.1 - 0.013 14.9 0.0 0.055 12.8 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOS18653.1 - 0.19 11.3 0.0 4.8 6.7 0.0 2.2 2 0 0 2 2 2 0 RIO1 family ELMO_CED12 PF04727.13 KOS18654.1 - 7.7e-50 169.4 0.0 5.7e-49 166.6 0.0 2.0 2 0 0 2 2 2 1 ELMO/CED-12 family PH_12 PF16457.5 KOS18654.1 - 2e-32 112.6 0.1 2.5e-31 109.0 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain DUF3361 PF11841.8 KOS18654.1 - 5e-13 49.3 0.0 9.9e-13 48.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3361) RPN1_RPN2_N PF17781.1 KOS18654.1 - 0.14 11.6 0.0 0.24 10.8 0.0 1.4 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain Cyclin_N PF00134.23 KOS18655.1 - 2.6e-43 146.8 0.2 1e-42 144.9 0.1 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOS18655.1 - 1.3e-35 122.0 0.1 4.3e-35 120.4 0.1 2.0 1 0 0 1 1 1 1 Cyclin, C-terminal domain TFIIA PF03153.13 KOS18655.1 - 2.6e-06 27.7 33.0 3.8e-06 27.2 33.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.10 KOS18655.1 - 2.6 8.5 16.5 5.8 7.4 16.5 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 KOS18655.1 - 5 6.4 15.5 8.6 5.6 15.5 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 KOS18655.1 - 9 4.3 11.5 13 3.7 11.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi IF-2B PF01008.17 KOS18657.1 - 4.4e-43 147.5 0.1 1.2e-42 146.0 0.1 1.7 1 1 0 1 1 1 1 Initiation factor 2 subunit family TAF4 PF05236.14 KOS18657.1 - 0.69 9.6 12.3 1.1 8.9 12.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Anp1 PF03452.14 KOS18658.1 - 1.8e-109 365.2 0.0 2.2e-109 364.9 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 KOS18658.1 - 0.00068 19.5 0.0 0.00099 18.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 FoP_duplication PF13865.6 KOS18659.1 - 3.4e-06 27.5 12.2 3.4e-06 27.5 12.2 2.0 1 1 1 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 KOS18659.1 - 5.1e-05 23.0 0.0 0.00011 21.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ICMT PF04140.14 KOS18660.1 - 2.2e-25 88.9 0.2 4.9e-25 87.8 0.2 1.5 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 KOS18660.1 - 3.3e-10 40.3 0.9 3.3e-10 40.3 0.9 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase DUF1295 PF06966.12 KOS18660.1 - 0.034 13.6 0.1 0.068 12.7 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) Tmemb_170 PF10190.9 KOS18661.1 - 3e-23 82.2 16.9 3.4e-23 82.0 16.9 1.0 1 0 0 1 1 1 1 Putative transmembrane protein 170 DAG1 PF05454.11 KOS18661.1 - 0.34 10.3 1.2 0.44 9.9 0.2 1.6 1 1 1 2 2 2 0 Dystroglycan (Dystrophin-associated glycoprotein 1) MSP1a PF11670.8 KOS18661.1 - 0.72 9.1 3.7 0.38 10.0 1.1 1.6 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) Endonuclease_NS PF01223.23 KOS18662.1 - 9.3e-64 215.3 0.0 1.1e-63 215.1 0.0 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease ORC6 PF05460.13 KOS18662.1 - 2 7.6 6.0 3 7.0 6.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) WD40 PF00400.32 KOS18663.1 - 5.3e-31 106.2 25.2 1.2e-05 26.0 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18663.1 - 1.3e-14 54.2 0.1 0.091 13.1 0.1 6.0 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS18663.1 - 0.0043 17.0 0.0 0.45 10.4 0.0 2.4 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 KOS18663.1 - 0.026 13.3 0.1 0.07 11.9 0.1 1.7 2 0 0 2 2 2 0 Nup133 N terminal like Ge1_WD40 PF16529.5 KOS18663.1 - 0.11 11.5 0.2 6.7 5.6 0.1 3.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 KOS18663.1 - 0.23 9.8 0.0 0.34 9.1 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1283 PF06932.11 KOS18663.1 - 6.4 7.1 6.2 96 3.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1283) Arf PF00025.21 KOS18664.1 - 4.2e-66 221.7 0.0 4.7e-66 221.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOS18664.1 - 7.5e-10 38.5 0.1 2.5e-06 26.9 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 KOS18664.1 - 1.2e-07 31.4 0.0 1.6e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS18664.1 - 1.5e-07 31.6 0.0 5.1e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOS18664.1 - 3.5e-07 29.8 0.0 4.6e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOS18664.1 - 3.5e-07 30.3 0.0 4.7e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS18664.1 - 8.4e-06 25.3 0.0 9.9e-06 25.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOS18664.1 - 0.008 15.7 0.1 0.33 10.5 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain CENP-M PF11111.8 KOS18664.1 - 0.064 12.4 0.0 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 Centromere protein M (CENP-M) Pkinase PF00069.25 KOS18665.1 - 1e-51 175.8 0.0 1.3e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18665.1 - 4.5e-37 127.7 0.0 6.2e-37 127.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS18665.1 - 0.00038 19.5 0.0 0.24 10.3 0.0 2.1 2 0 0 2 2 2 2 Haspin like kinase domain Pkinase_fungal PF17667.1 KOS18665.1 - 0.0007 18.5 0.0 0.0013 17.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS18665.1 - 0.0056 16.0 0.0 0.015 14.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOS18665.1 - 0.04 13.8 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family ABC1 PF03109.16 KOS18665.1 - 0.052 13.7 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC1 family DUF2457 PF10446.9 KOS18666.1 - 7.2e-158 526.6 31.4 7.2e-158 526.6 31.4 2.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2457) TFIIA PF03153.13 KOS18666.1 - 2.2e-05 24.7 13.5 5.1e-05 23.5 13.5 1.6 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Alb1 PF09135.11 KOS18666.1 - 0.52 11.2 4.6 0.29 12.0 0.7 2.6 2 0 0 2 2 2 0 Alb1 BUD22 PF09073.10 KOS18666.1 - 1.3 8.2 30.7 0.077 12.3 23.6 2.2 2 0 0 2 2 2 0 BUD22 ATP-synt_DE_N PF02823.16 KOS18668.1 - 9.1e-18 63.9 0.0 1.7e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain YdaT_toxin PF06254.11 KOS18670.1 - 0.043 14.4 0.9 0.088 13.4 0.9 1.6 1 0 0 1 1 1 0 Putative bacterial toxin ydaT DUF948 PF06103.11 KOS18670.1 - 0.99 9.7 4.4 3.6 7.9 1.2 2.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) MFS_1 PF07690.16 KOS18671.1 - 1.1e-28 100.2 29.6 1.1e-28 100.2 29.6 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sds3 PF08598.11 KOS18673.1 - 4.4e-14 53.0 0.3 4.4e-14 53.0 0.3 2.0 2 0 0 2 2 2 1 Sds3-like RRM_1 PF00076.22 KOS18674.1 - 1.6e-09 37.4 2.1 2.7e-08 33.5 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PBP1_TM PF14812.6 KOS18674.1 - 0.0027 18.0 16.5 0.0027 18.0 16.5 5.1 4 1 1 5 5 5 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Flot PF15975.5 KOS18674.1 - 0.051 13.8 0.1 0.051 13.8 0.1 2.8 3 0 0 3 3 3 0 Flotillin DUF3453 PF11935.8 KOS18675.1 - 1.1e-64 218.2 0.2 3.6e-64 216.5 0.0 1.9 3 0 0 3 3 3 1 Domain of unknown function (DUF3453) PDCD7 PF16021.5 KOS18675.1 - 0.066 12.3 1.5 0.081 12.0 0.6 1.5 2 0 0 2 2 2 0 Programmed cell death protein 7 Coiled-coil_56 PF09813.9 KOS18676.1 - 9e-06 25.7 0.0 9.2e-06 25.6 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 56 Tubulin PF00091.25 KOS18677.1 - 1.8e-63 214.3 0.0 2.5e-63 213.9 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOS18677.1 - 1.9e-42 144.4 0.0 3.5e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KOS18677.1 - 0.0037 17.0 0.0 0.007 16.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain DUF2723 PF11028.8 KOS18678.1 - 0.0026 17.7 0.0 0.0038 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) Gram_pos_anchor PF00746.21 KOS18678.1 - 0.14 12.1 1.1 0.27 11.2 1.1 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF5305 PF17231.2 KOS18678.1 - 0.16 11.4 0.0 0.37 10.2 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5305) MerR-DNA-bind PF09278.11 KOS18678.1 - 1.2 9.7 6.1 0.16 12.5 1.2 2.0 3 0 0 3 3 3 0 MerR, DNA binding CcmD PF04995.14 KOS18678.1 - 5.1 7.3 5.7 3.9 7.6 0.3 2.5 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) PRA1 PF03208.19 KOS18679.1 - 7.7e-33 113.1 1.1 9.5e-33 112.8 1.1 1.0 1 0 0 1 1 1 1 PRA1 family protein SPC25 PF06703.11 KOS18679.1 - 0.03 14.1 0.1 0.043 13.6 0.1 1.3 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) E1-E2_ATPase PF00122.20 KOS18679.1 - 0.15 11.6 2.2 0.57 9.7 2.2 1.8 1 1 0 1 1 1 0 E1-E2 ATPase DUF2207 PF09972.9 KOS18679.1 - 1.5 7.5 2.8 1.9 7.2 2.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PEARLI-4 PF05278.12 KOS18680.1 - 0.0034 17.0 4.3 0.0058 16.3 4.3 1.4 1 0 0 1 1 1 1 Arabidopsis phospholipase-like protein (PEARLI 4) PV-1 PF06637.11 KOS18680.1 - 0.0053 15.6 3.0 0.0072 15.2 3.0 1.1 1 0 0 1 1 1 1 PV-1 protein (PLVAP) eIF3_subunit PF08597.10 KOS18680.1 - 0.42 10.5 19.4 0.69 9.8 19.4 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DNA_pol_phi PF04931.13 KOS18680.1 - 0.54 8.3 15.4 0.74 7.8 15.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi UQ_con PF00179.26 KOS18681.1 - 2.5e-32 111.4 0.0 2.9e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_E PF14462.6 KOS18681.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family E Dus PF01207.17 KOS18682.1 - 1.3e-43 149.3 0.1 4.4e-43 147.5 0.1 1.8 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 KOS18682.1 - 0.011 15.1 0.1 0.025 13.9 0.1 1.6 1 0 0 1 1 1 0 Thiamine monophosphate synthase PucR PF07905.11 KOS18682.1 - 0.25 11.6 0.6 0.94 9.8 0.1 2.3 2 1 1 3 3 3 0 Purine catabolism regulatory protein-like family Oxysterol_BP PF01237.18 KOS18684.1 - 7.7e-90 301.4 0.1 1.9e-87 293.5 0.1 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein zf-CCCH PF00642.24 KOS18685.1 - 1.2e-08 34.6 18.6 5.3e-07 29.4 2.6 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 KOS18685.1 - 0.0041 16.9 0.0 0.0064 16.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 KOS18685.1 - 0.011 16.4 3.5 0.4 11.4 0.2 2.4 2 0 0 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 KOS18685.1 - 0.012 15.6 2.9 0.012 15.6 2.9 3.3 3 0 0 3 3 3 0 Zinc finger domain zf-CCCH_3 PF15663.5 KOS18685.1 - 0.2 11.9 3.7 0.37 11.0 0.1 2.4 2 1 0 2 2 2 0 Zinc-finger containing family DUF410 PF04190.13 KOS18686.1 - 1e-92 310.6 0.0 1.2e-92 310.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) DUF1059 PF06348.11 KOS18687.1 - 0.06 13.6 1.9 0.11 12.8 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1059) NPCC PF08058.11 KOS18689.1 - 4.3e-26 91.5 0.0 7.5e-26 90.7 0.0 1.4 1 0 0 1 1 1 1 Nuclear pore complex component NmrA PF05368.13 KOS18690.1 - 9.3e-82 274.1 0.0 1.2e-81 273.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOS18690.1 - 1.9e-10 40.9 0.1 1.2e-09 38.3 0.1 2.0 1 1 0 1 1 1 1 NAD(P)H-binding ERG2_Sigma1R PF04622.12 KOS18691.1 - 9.5e-97 322.4 0.0 1.1e-96 322.1 0.0 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein UCR_6-4kD PF08997.10 KOS18691.1 - 0.1 12.6 0.1 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase complex, 6.4kD protein Fcf1 PF04900.12 KOS18692.1 - 4.9e-34 116.7 0.1 7.7e-34 116.1 0.1 1.3 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 KOS18692.1 - 1.7e-11 44.4 0.3 3.2e-11 43.5 0.0 1.6 2 0 0 2 2 2 1 PIN like domain Fungal_trans PF04082.18 KOS18693.1 - 3.8e-12 45.8 0.4 5.2e-12 45.4 0.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS18693.1 - 2.1e-06 27.7 10.6 3.8e-06 26.9 10.6 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Rep_fac_C PF08542.11 KOS18695.1 - 1.3e-24 86.4 0.0 5.4e-24 84.4 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KOS18695.1 - 6.9e-12 45.4 0.0 1.2e-08 34.9 0.0 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA PF00004.29 KOS18695.1 - 2.2e-11 44.3 0.0 4.3e-11 43.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KOS18695.1 - 6.5e-07 29.4 0.0 1.3e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS18695.1 - 2.5e-06 28.0 0.0 0.00013 22.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KOS18695.1 - 3.1e-05 23.8 0.0 7.1e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOS18695.1 - 9.8e-05 22.6 0.1 0.16 12.3 0.0 2.6 1 1 1 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 KOS18695.1 - 0.00014 21.7 0.0 0.00022 21.0 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 KOS18695.1 - 0.00017 21.5 0.0 0.00037 20.4 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta PF06144.13 KOS18695.1 - 0.0021 17.9 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOS18695.1 - 0.0031 17.4 0.0 0.0061 16.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain Mg_chelatase PF01078.21 KOS18695.1 - 0.0034 16.8 0.0 0.029 13.8 0.0 2.1 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MeaB PF03308.16 KOS18695.1 - 0.0051 15.8 0.0 0.0094 15.0 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_assoc_2 PF16193.5 KOS18695.1 - 0.0072 16.6 0.0 0.021 15.1 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 KOS18695.1 - 0.0099 15.7 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain DNA_pol3_gamma3 PF12169.8 KOS18695.1 - 0.018 14.9 0.4 0.9 9.4 0.0 2.9 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III NTPase_1 PF03266.15 KOS18695.1 - 0.021 14.8 0.1 0.066 13.1 0.1 1.9 1 1 1 2 2 2 0 NTPase TniB PF05621.11 KOS18695.1 - 0.022 14.2 0.0 2.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 KOS18695.1 - 0.025 14.9 0.1 0.069 13.5 0.1 1.8 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 KOS18695.1 - 0.027 14.2 0.1 1.1 9.0 0.0 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase KTI12 PF08433.10 KOS18695.1 - 0.027 13.9 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_24 PF13479.6 KOS18695.1 - 0.029 14.1 0.0 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KOS18695.1 - 0.11 12.5 0.1 0.5 10.4 0.0 2.1 3 1 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KOS18695.1 - 0.11 12.2 0.0 0.39 10.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOS18695.1 - 0.13 11.8 0.1 0.55 9.8 0.1 2.0 1 1 1 2 2 2 0 AAA domain IKI3 PF04762.12 KOS18696.1 - 4.6e-257 855.6 0.0 5.7e-216 719.6 0.0 2.0 1 1 1 2 2 2 2 IKI3 family ANAPC4_WD40 PF12894.7 KOS18696.1 - 2.3e-05 24.6 0.5 5.6 7.3 0.0 4.7 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Inj_translocase PF16928.5 KOS18696.1 - 0.045 13.2 0.4 0.11 12.0 0.4 1.5 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome S-AdoMet_synt_C PF02773.16 KOS18697.1 - 5.6e-65 217.5 0.5 9.5e-65 216.8 0.0 1.6 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 KOS18697.1 - 4.6e-44 149.5 0.0 8.2e-44 148.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 KOS18697.1 - 3.3e-43 146.4 0.4 9.3e-43 145.0 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 KOS18697.1 - 0.14 11.0 0.3 0.72 8.6 0.1 2.0 1 1 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) ATP_bind_1 PF03029.17 KOS18698.1 - 5.3e-73 245.8 0.0 7e-73 245.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 KOS18698.1 - 0.00085 19.2 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_14 PF13173.6 KOS18698.1 - 0.0012 18.9 0.0 0.0031 17.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KOS18698.1 - 0.007 16.1 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOS18698.1 - 0.0076 16.2 0.1 0.41 10.5 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 KOS18698.1 - 0.011 16.2 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 KOS18698.1 - 0.012 16.2 0.0 0.036 14.6 0.0 1.9 1 1 0 1 1 1 0 AAA domain CbiA PF01656.23 KOS18698.1 - 0.013 15.5 0.0 0.021 14.9 0.0 1.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 KOS18698.1 - 0.023 15.0 0.0 0.047 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOS18698.1 - 0.025 14.3 0.0 0.051 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 KOS18698.1 - 0.035 13.6 0.0 6.5 6.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 KOS18698.1 - 0.043 14.0 0.0 0.067 13.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOS18698.1 - 0.046 14.2 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 KOS18698.1 - 0.053 13.9 0.6 0.85 10.0 0.0 2.6 1 1 2 3 3 3 0 AAA ATPase domain AAA_10 PF12846.7 KOS18698.1 - 0.098 11.6 0.0 0.25 10.2 0.0 1.6 2 0 0 2 2 2 0 AAA-like domain Cytidylate_kin PF02224.18 KOS18698.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase MMR_HSR1 PF01926.23 KOS18698.1 - 0.15 12.2 0.0 0.51 10.4 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase SRP54 PF00448.22 KOS18698.1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_7 PF12775.7 KOS18698.1 - 0.2 11.2 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PI-PLC-X PF00388.19 KOS18699.1 - 7.6e-05 22.3 0.0 0.00011 21.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain MaoC_dehydratas PF01575.19 KOS18701.1 - 2.1e-20 72.6 0.0 3.3e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 KOS18701.1 - 1.2e-05 25.5 0.0 0.00013 22.1 0.0 2.2 2 1 0 2 2 2 1 N-terminal half of MaoC dehydratase ERp29_N PF07912.13 KOS18701.1 - 0.057 13.6 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 ERp29, N-terminal domain DUF1349 PF07081.11 KOS18703.1 - 1.3e-27 96.7 0.0 2.8e-25 89.1 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF1349) Pcc1 PF09341.10 KOS18703.1 - 0.083 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 Transcription factor Pcc1 DUF3328 PF11807.8 KOS18703.1 - 0.14 11.9 0.1 0.22 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) CAP_GLY PF01302.25 KOS18704.1 - 9.6e-19 67.2 0.1 2.1e-18 66.1 0.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain LRR_4 PF12799.7 KOS18704.1 - 4.4e-13 49.2 3.2 0.17 12.3 1.4 5.4 6 0 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS18704.1 - 1.8e-11 43.6 0.6 0.0047 16.7 0.4 4.7 5 0 0 5 5 5 3 Leucine rich repeat LRR_9 PF14580.6 KOS18704.1 - 6.3e-05 22.6 2.1 0.39 10.2 0.0 3.7 3 1 2 5 5 5 2 Leucine-rich repeat LRR_6 PF13516.6 KOS18704.1 - 0.00033 20.5 6.6 14 6.1 0.3 6.0 6 0 0 6 6 6 2 Leucine Rich repeat ATP-synt_E PF05680.12 KOS18705.1 - 8.1e-21 74.2 0.9 1e-20 73.9 0.9 1.0 1 0 0 1 1 1 1 ATP synthase E chain ABC_trans_N PF14510.6 KOS18705.1 - 0.024 15.3 0.4 0.03 15.0 0.4 1.2 1 0 0 1 1 1 0 ABC-transporter N-terminal WD40 PF00400.32 KOS18706.1 - 1.1e-09 38.7 4.5 0.53 11.2 0.5 6.3 6 1 0 6 6 6 3 WD domain, G-beta repeat TIM PF00121.18 KOS18708.1 - 2.6e-87 292.2 0.1 2.9e-87 292.1 0.1 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase Toprim PF01751.22 KOS18708.1 - 0.058 13.6 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Toprim domain Lsr2 PF11774.8 KOS18708.1 - 0.07 13.3 0.2 0.13 12.4 0.2 1.5 1 0 0 1 1 1 0 Lsr2 CutC PF03932.14 KOS18708.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 CutC family L51_S25_CI-B8 PF05047.16 KOS18709.1 - 1.3e-15 57.1 0.0 2.2e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain GHL10 PF02638.15 KOS18709.1 - 0.059 12.4 0.0 0.061 12.4 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase-like 10 U1snRNP70_N PF12220.8 KOS18710.1 - 9.8e-25 87.0 4.3 9.8e-25 87.0 4.3 1.6 2 0 0 2 2 2 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 KOS18710.1 - 1.1e-10 41.2 0.1 6.2e-10 38.8 0.1 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS18710.1 - 0.00029 20.9 0.0 0.00051 20.1 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif Ribosomal_L10 PF00466.20 KOS18711.1 - 8.4e-21 74.0 0.0 1.2e-20 73.5 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 KOS18711.1 - 2.6e-19 69.0 0.0 4.6e-19 68.2 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P NTF2 PF02136.20 KOS18712.1 - 1.1e-23 84.1 0.3 1.8e-23 83.4 0.3 1.3 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 KOS18712.1 - 3.3e-05 23.6 0.0 5.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dzip-like_N PF13815.6 KOS18712.1 - 0.089 12.8 2.6 0.17 11.9 2.6 1.5 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal PH_9 PF15410.6 KOS18713.1 - 1.4e-08 35.1 0.0 2.1e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain Nnf1 PF03980.14 KOS18714.1 - 1.6e-26 92.9 0.8 1.6e-26 92.9 0.8 4.1 4 1 0 4 4 2 1 Nnf1 SR-25 PF10500.9 KOS18714.1 - 0.0046 16.6 14.2 0.0083 15.8 14.2 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein EPL1 PF10513.9 KOS18714.1 - 0.005 17.2 3.9 0.0078 16.6 3.9 1.4 1 0 0 1 1 1 1 Enhancer of polycomb-like Eapp_C PF10238.9 KOS18714.1 - 0.02 15.0 5.1 0.028 14.5 5.1 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein Rrn6 PF10214.9 KOS18714.1 - 0.065 11.7 15.6 0.087 11.3 15.6 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor CDC45 PF02724.14 KOS18714.1 - 0.094 11.0 8.7 0.13 10.5 8.7 1.2 1 0 0 1 1 1 0 CDC45-like protein ASC PF00858.24 KOS18714.1 - 0.14 11.0 0.1 0.14 11.1 0.1 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Presenilin PF01080.17 KOS18714.1 - 0.15 10.8 8.2 0.18 10.6 8.2 1.1 1 0 0 1 1 1 0 Presenilin NST1 PF13945.6 KOS18714.1 - 0.29 11.2 16.6 0.45 10.6 16.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator SpoIIP PF07454.11 KOS18714.1 - 0.35 10.3 6.6 0.45 9.9 6.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 KOS18714.1 - 0.46 10.5 10.0 0.79 9.7 10.0 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FmiP_Thoc5 PF09766.9 KOS18714.1 - 0.61 9.3 18.2 0.3 10.3 15.1 1.8 2 0 0 2 2 2 0 Fms-interacting protein/Thoc5 Coilin_N PF15862.5 KOS18714.1 - 0.7 9.7 16.6 1.2 8.9 16.6 1.3 1 0 0 1 1 1 0 Coilin N-terminus Pex14_N PF04695.13 KOS18714.1 - 0.76 10.4 16.9 0.16 12.6 13.1 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BRF1 PF07741.13 KOS18714.1 - 0.78 10.1 11.9 1.7 9.1 11.9 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain MDM10 PF12519.8 KOS18714.1 - 1 8.2 5.2 1.3 7.8 5.2 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2828 PF11443.8 KOS18714.1 - 1 7.4 9.3 1.3 7.0 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Dicty_REP PF05086.12 KOS18714.1 - 1.1 7.1 3.1 1.2 7.0 3.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein eIF3_subunit PF08597.10 KOS18714.1 - 1.2 9.0 14.9 2.3 8.1 14.9 1.4 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF4770 PF15994.5 KOS18714.1 - 1.4 9.2 12.1 2.3 8.4 12.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) NARP1 PF12569.8 KOS18714.1 - 1.4 7.8 15.9 1.5 7.6 12.5 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 YL1 PF05764.13 KOS18714.1 - 1.8 8.6 23.0 2.4 8.2 23.0 1.4 1 1 0 1 1 1 0 YL1 nuclear protein DUF1764 PF08576.10 KOS18714.1 - 1.9 9.4 11.9 4.3 8.3 11.9 1.6 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3391 PF11871.8 KOS18714.1 - 2.2 8.8 18.6 1.9 9.0 11.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) MAP65_ASE1 PF03999.12 KOS18714.1 - 2.3 6.8 16.7 13 4.4 16.8 1.7 1 1 1 2 2 2 0 Microtubule associated protein (MAP65/ASE1 family) ALMT PF11744.8 KOS18714.1 - 2.5 6.8 7.2 4.2 6.1 4.9 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter YqfQ PF14181.6 KOS18714.1 - 2.9 8.1 11.5 4.9 7.3 11.5 1.3 1 0 0 1 1 1 0 YqfQ-like protein DUF3381 PF11861.8 KOS18714.1 - 3.1 7.6 18.7 7.7 6.3 18.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Connexin PF00029.19 KOS18714.1 - 3.1 7.5 8.9 4.5 7.0 8.9 1.2 1 0 0 1 1 1 0 Connexin Baculo_PP31 PF05311.11 KOS18714.1 - 3.7 7.0 15.3 5.8 6.3 15.3 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) TMEM214 PF10151.9 KOS18714.1 - 4.3 5.7 9.7 6.6 5.1 9.7 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator RR_TM4-6 PF06459.12 KOS18714.1 - 5 6.9 13.1 7.9 6.2 13.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Herpes_DNAp_acc PF04929.12 KOS18714.1 - 5.7 5.8 10.1 8.8 5.2 10.1 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CPSF100_C PF13299.6 KOS18714.1 - 5.9 7.0 11.8 2.1 8.5 8.9 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DDRGK PF09756.9 KOS18714.1 - 8 6.0 19.2 15 5.1 19.2 1.4 1 0 0 1 1 1 0 DDRGK domain DUF1640 PF07798.11 KOS18715.1 - 6.9e-46 156.5 6.0 6.9e-46 156.5 6.0 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1640) Mucin PF01456.17 KOS18715.1 - 0.0086 16.1 16.4 0.017 15.1 16.4 1.5 1 0 0 1 1 1 1 Mucin-like glycoprotein Connexin PF00029.19 KOS18715.1 - 0.26 11.0 0.0 0.26 11.0 0.0 3.0 4 0 0 4 4 4 0 Connexin FSA_C PF10479.9 KOS18715.1 - 0.48 8.5 7.2 0.66 8.0 7.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 KOS18715.1 - 0.88 7.7 17.7 1.6 6.8 17.7 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1664 PF07889.12 KOS18715.1 - 6.8 6.8 8.8 0.51 10.4 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) PUF PF00806.19 KOS18716.1 - 4.1e-62 202.5 6.7 1.6e-08 33.8 0.1 8.2 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 KOS18716.1 - 0.00017 21.9 5.7 5 7.5 0.0 4.1 1 1 2 4 4 4 2 CPL (NUC119) domain LOB PF03195.14 KOS18716.1 - 0.0045 17.5 2.1 0.45 11.1 0.1 3.0 1 1 1 3 3 3 1 Lateral organ boundaries (LOB) domain sCache_2 PF17200.4 KOS18716.1 - 0.0087 15.9 1.3 8.2 6.3 0.0 3.8 3 1 1 4 4 4 1 Single Cache domain 2 MgtE_N PF03448.17 KOS18716.1 - 0.041 14.5 1.4 13 6.5 0.0 3.3 4 0 0 4 4 4 0 MgtE intracellular N domain DUF234 PF03008.14 KOS18716.1 - 0.14 12.6 3.3 0.82 10.2 0.2 2.8 3 0 0 3 3 3 0 Archaea bacterial proteins of unknown function Mg_trans_NIPA PF05653.14 KOS18717.1 - 3.4e-101 338.2 13.4 4e-101 338.0 13.4 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOS18717.1 - 6.2e-05 23.2 6.0 6.2e-05 23.2 6.0 3.6 3 1 0 3 3 3 2 EamA-like transporter family Ribosomal_S3_C PF00189.20 KOS18718.1 - 7.4e-25 87.3 0.2 4.1e-24 84.9 0.2 2.1 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 KOS18718.1 - 6.3e-12 45.2 0.1 1.1e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 KH domain UN_NPL4 PF11543.8 KOS18718.1 - 0.099 13.1 0.0 0.2 12.2 0.0 1.5 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Coilin_N PF15862.5 KOS18718.1 - 0.17 11.7 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Coilin N-terminus Abhydrolase_2 PF02230.16 KOS18719.1 - 1.3e-45 155.8 0.0 7.3e-32 110.9 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase FSH1 PF03959.13 KOS18719.1 - 1.5e-05 24.7 0.0 4e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 KOS18719.1 - 4.9e-05 22.7 0.9 3.3 6.9 0.0 3.2 2 1 1 3 3 3 3 Serine aminopeptidase, S33 DLH PF01738.18 KOS18719.1 - 0.023 14.2 0.0 0.046 13.3 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 KOS18719.1 - 0.059 13.0 0.2 0.71 9.5 0.2 2.3 1 1 1 2 2 2 0 alpha/beta hydrolase fold Esterase PF00756.20 KOS18719.1 - 0.076 12.7 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 Putative esterase Abhydrolase_3 PF07859.13 KOS18719.1 - 0.14 12.0 0.0 2.9 7.7 0.0 2.4 2 1 1 3 3 3 0 alpha/beta hydrolase fold Adap_comp_sub PF00928.21 KOS18720.1 - 6.7e-16 58.5 0.0 1.1e-15 57.7 0.0 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOS18720.1 - 1.4e-07 31.6 0.3 2.6e-07 30.7 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain muHD PF10291.9 KOS18720.1 - 0.00015 21.3 0.0 0.00059 19.4 0.0 1.8 1 1 0 1 1 1 1 Muniscin C-terminal mu homology domain RPM2 PF08579.11 KOS18720.1 - 0.0022 18.4 0.7 0.0042 17.5 0.3 1.7 2 0 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) DUF3432 PF11914.8 KOS18722.1 - 3.8 7.8 29.5 26 5.1 1.9 5.1 1 1 2 3 3 3 0 Domain of unknown function (DUF3432) Myotub-related PF06602.14 KOS18723.1 - 5e-138 459.8 0.1 6.8e-138 459.4 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 KOS18723.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family tRNA_synthFbeta PF17759.1 KOS18724.1 - 9.6e-45 152.6 0.0 1.4e-44 152.1 0.0 1.3 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain PhetRS_B1 PF18262.1 KOS18724.1 - 2.1e-31 107.9 0.2 7.1e-31 106.3 0.1 1.9 2 0 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B3_4 PF03483.17 KOS18724.1 - 1.8e-23 83.1 0.0 3.1e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 B3/4 domain B5 PF03484.15 KOS18724.1 - 1.8e-15 57.0 0.0 3.5e-13 49.6 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetase B5 domain UQ_con PF00179.26 KOS18725.1 - 3.7e-25 88.2 0.0 4.5e-25 87.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS18725.1 - 6.1e-07 29.2 0.0 7.5e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOS18725.1 - 0.00016 21.5 0.0 0.00022 21.1 0.0 1.2 1 0 0 1 1 1 1 UEV domain RWD PF05773.22 KOS18725.1 - 0.012 15.9 0.0 0.016 15.5 0.0 1.3 1 0 0 1 1 1 0 RWD domain Sec1 PF00995.23 KOS18726.1 - 1.8e-119 400.6 0.0 2.1e-119 400.4 0.0 1.0 1 0 0 1 1 1 1 Sec1 family DGCR6 PF07324.11 KOS18726.1 - 0.021 14.4 0.7 0.11 12.1 0.2 2.4 2 1 1 3 3 3 0 DiGeorge syndrome critical region 6 (DGCR6) protein DUF2383 PF09537.10 KOS18726.1 - 0.1 12.9 0.3 20 5.6 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2383) PGAP1 PF07819.13 KOS18727.1 - 3.6e-05 23.6 0.0 9.8e-05 22.2 0.0 1.7 1 1 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 KOS18727.1 - 0.00032 20.3 0.0 0.00051 19.6 0.0 1.4 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 KOS18727.1 - 0.0044 17.6 0.2 0.0059 17.2 0.2 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family IL32 PF15225.6 KOS18729.1 - 0.013 15.8 0.0 0.048 14.0 0.0 1.9 1 0 0 1 1 1 0 Interleukin 32 Pkinase PF00069.25 KOS18730.1 - 1.6e-69 234.2 0.0 2.1e-69 233.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18730.1 - 7.5e-35 120.5 0.0 1e-34 120.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS18730.1 - 2.5e-06 27.0 0.0 5.5e-06 25.9 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOS18730.1 - 0.00014 20.7 0.0 0.00029 19.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 KOS18730.1 - 0.0023 17.5 0.3 0.01 15.3 0.1 2.2 3 0 0 3 3 3 1 PhoP regulatory network protein YrbL Kdo PF06293.14 KOS18730.1 - 0.0038 16.6 0.1 0.0071 15.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TetR_C_27 PF17935.1 KOS18730.1 - 0.073 13.1 0.0 0.59 10.2 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Hydrolase_4 PF12146.8 KOS18731.1 - 1.4e-11 44.1 1.3 2.3e-11 43.5 0.0 1.9 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOS18731.1 - 1.4e-10 42.2 6.2 2.6e-10 41.3 6.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS18731.1 - 3.5e-08 33.4 0.6 7.6e-08 32.3 0.3 1.6 2 0 0 2 2 2 1 alpha/beta hydrolase fold UPF0227 PF05728.12 KOS18731.1 - 0.0026 17.8 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0227) Esterase PF00756.20 KOS18731.1 - 0.0028 17.3 0.5 0.0045 16.7 0.5 1.2 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 KOS18731.1 - 0.021 14.9 0.8 3.7 7.6 0.2 2.4 2 0 0 2 2 2 0 Thioesterase domain Lipase_3 PF01764.25 KOS18731.1 - 0.058 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Lipase (class 3) Ndr PF03096.14 KOS18731.1 - 0.28 9.9 0.1 0.52 9.0 0.1 1.5 1 1 0 1 1 1 0 Ndr family tRNA-synt_His PF13393.6 KOS18732.1 - 6.4e-38 130.8 0.0 1.7e-31 109.6 0.0 2.1 2 0 0 2 2 2 2 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 KOS18732.1 - 6.8e-13 48.6 0.0 1.3e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain HGTP_anticodon2 PF12745.7 KOS18732.1 - 3.9e-05 23.3 0.0 6.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs tRNA-synt_2b PF00587.25 KOS18732.1 - 0.00011 22.2 0.0 0.00029 20.8 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Ribosomal_60s PF00428.19 KOS18732.1 - 0.012 16.1 2.5 0.042 14.4 2.5 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein tRNA-synt_2 PF00152.20 KOS18732.1 - 0.015 14.4 0.0 0.089 11.9 0.0 1.9 1 1 0 2 2 2 0 tRNA synthetases class II (D, K and N) C2 PF00168.30 KOS18733.1 - 7e-83 273.6 0.1 6.4e-22 77.8 0.0 5.4 5 0 0 5 5 5 5 C2 domain SMP_LBD PF17047.5 KOS18733.1 - 0.0018 17.7 0.0 0.0076 15.7 0.0 1.9 1 1 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain MLVIN_C PF18697.1 KOS18733.1 - 0.059 13.5 0.4 3.4 7.8 0.0 3.3 3 0 0 3 3 3 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain zf-RING_2 PF13639.6 KOS18734.1 - 1.5e-06 28.4 11.4 2.9e-06 27.5 3.1 2.6 2 1 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 KOS18734.1 - 8.8e-05 22.2 4.3 8.8e-05 22.2 4.3 2.6 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KOS18734.1 - 0.00096 19.1 2.5 0.00096 19.1 2.5 2.6 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOS18734.1 - 0.0054 16.5 9.6 0.012 15.4 2.3 2.6 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 KOS18734.1 - 0.017 15.4 1.5 0.017 15.4 1.5 2.1 2 0 0 2 2 2 0 RING-like domain zf-C3HC4 PF00097.25 KOS18734.1 - 0.018 14.9 2.1 0.018 14.9 2.1 2.5 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C2H2_6 PF13912.6 KOS18734.1 - 0.041 13.9 0.8 8.2 6.6 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger FANCL_C PF11793.8 KOS18734.1 - 0.048 13.8 5.2 0.52 10.5 3.5 2.5 2 1 0 2 2 2 0 FANCL C-terminal domain zf-rbx1 PF12678.7 KOS18734.1 - 0.33 11.3 9.8 1.2 9.5 5.2 2.9 2 1 0 2 2 2 0 RING-H2 zinc finger domain WD40 PF00400.32 KOS18735.1 - 4.4e-10 40.0 0.1 2.8 9.0 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat RXT2_N PF08595.11 KOS18735.1 - 1.1 9.3 8.2 6.4 6.8 0.4 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF3439 PF11921.8 KOS18735.1 - 2.2 8.3 11.6 4.7 7.2 11.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAM176 PF14851.6 KOS18735.1 - 7.7 6.2 13.2 11 5.6 2.9 2.4 2 0 0 2 2 2 0 FAM176 family INSIG PF07281.12 KOS18736.1 - 2.2e-58 197.4 2.4 2.7e-58 197.1 2.4 1.1 1 0 0 1 1 1 1 Insulin-induced protein (INSIG) TM140 PF14985.6 KOS18736.1 - 0.038 13.5 0.2 0.07 12.7 0.2 1.3 1 0 0 1 1 1 0 TM140 protein family DUF4131 PF13567.6 KOS18736.1 - 0.66 9.6 5.5 0.33 10.6 0.4 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Evr1_Alr PF04777.13 KOS18738.1 - 5.1e-28 97.5 0.0 7.3e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Erv1 / Alr family Proteasome PF00227.26 KOS18739.1 - 2.7e-46 157.5 0.2 3.1e-46 157.3 0.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Cyclin PF08613.11 KOS18740.1 - 5e-43 147.2 0.3 2e-25 90.1 0.1 2.1 2 0 0 2 2 2 2 Cyclin Serglycin PF04360.12 KOS18740.1 - 0.00053 20.0 0.6 0.12 12.3 0.2 2.3 2 0 0 2 2 2 2 Serglycin DUF1640 PF07798.11 KOS18742.1 - 7e-58 195.5 9.8 8.4e-58 195.3 9.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) GNAT_acetyltr_2 PF13718.6 KOS18742.1 - 0.022 14.2 1.3 0.061 12.7 0.1 1.9 1 1 1 2 2 2 0 GNAT acetyltransferase 2 cwf21 PF08312.12 KOS18742.1 - 0.076 13.2 5.4 0.26 11.5 2.4 2.5 2 1 0 2 2 2 0 cwf21 domain Lzipper-MIP1 PF14389.6 KOS18742.1 - 0.2 11.9 4.3 10 6.5 0.1 2.6 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Metal_resist PF13801.6 KOS18742.1 - 0.79 9.9 9.2 0.065 13.4 3.3 2.3 2 1 1 3 3 3 0 Heavy-metal resistance DUF1690 PF07956.11 KOS18742.1 - 9.7 6.6 14.7 7.5 7.0 7.6 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) TPR_2 PF07719.17 KOS18743.1 - 2.8e-14 52.0 21.7 0.046 13.8 0.4 9.9 10 1 0 10 10 10 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS18743.1 - 1.3e-12 46.9 0.1 0.0099 16.0 0.1 7.1 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS18743.1 - 1.6e-11 44.5 16.0 0.00047 20.6 2.0 7.0 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS18743.1 - 5.6e-11 41.9 0.1 0.18 11.5 0.0 5.9 4 1 2 6 6 6 3 TPR repeat TPR_1 PF00515.28 KOS18743.1 - 7.5e-09 35.0 11.0 0.092 12.6 0.1 7.3 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18743.1 - 9.6e-08 32.6 54.8 6.6e-07 29.9 6.1 8.5 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOS18743.1 - 1.2e-07 31.9 52.2 0.006 17.3 0.3 10.6 4 2 8 12 12 11 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS18743.1 - 5.6e-07 29.7 4.0 0.00055 20.1 0.1 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 KOS18743.1 - 7.4e-07 28.7 7.1 2.2e-05 23.8 4.5 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS18743.1 - 1.4e-06 27.9 6.4 0.3 11.2 0.1 5.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOS18743.1 - 0.00011 22.3 0.1 13 6.4 0.0 5.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOS18743.1 - 0.0038 17.5 24.2 0.0038 17.5 0.8 7.2 5 2 2 7 7 7 1 Tetratricopeptide repeat DUF3856 PF12968.7 KOS18743.1 - 0.076 13.1 1.7 0.59 10.2 0.4 2.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.6 KOS18743.1 - 0.1 13.2 17.1 1 10.1 0.2 6.0 7 0 0 7 7 6 0 Tetratricopeptide repeat CbtA PF09490.10 KOS18744.1 - 0.11 12.3 0.0 0.24 11.1 0.0 1.5 2 0 0 2 2 2 0 Probable cobalt transporter subunit (CbtA) Globin PF00042.22 KOS18745.1 - 3.3e-08 34.0 0.0 5.2e-08 33.4 0.0 1.3 1 0 0 1 1 1 1 Globin NAD_binding_1 PF00175.21 KOS18745.1 - 1.6e-06 28.7 0.0 4.3e-06 27.3 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOS18745.1 - 0.00043 20.6 0.0 0.16 12.3 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOS18745.1 - 0.013 15.6 0.0 0.081 13.1 0.0 2.1 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Mito_fiss_Elm1 PF06258.11 KOS18745.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial fission ELM1 HET PF06985.11 KOS18747.1 - 5.2e-12 46.3 8.5 2.4e-10 40.9 1.4 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) AA_permease PF00324.21 KOS18749.1 - 2.3e-128 428.8 44.1 2.7e-128 428.6 44.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS18749.1 - 9.5e-36 123.5 47.1 1.1e-35 123.3 47.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3671 PF12420.8 KOS18749.1 - 0.16 12.1 2.5 0.34 11.0 0.1 2.8 2 1 0 2 2 2 0 Protein of unknown function ADH_N PF08240.12 KOS18750.1 - 7.1e-15 54.8 0.1 1.3e-14 54.0 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS18750.1 - 8.1e-10 38.8 0.2 8.1e-10 38.8 0.2 2.6 2 1 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOS18750.1 - 7.7e-05 22.1 0.5 0.00012 21.5 0.5 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOS18750.1 - 0.0025 17.1 1.0 0.0034 16.7 1.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ADH_zinc_N_2 PF13602.6 KOS18750.1 - 0.0096 17.0 0.0 0.02 15.9 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 3HCDH_N PF02737.18 KOS18750.1 - 0.13 12.1 0.7 0.19 11.6 0.7 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 KOS18750.1 - 2 7.7 4.6 3.3 7.0 4.6 1.2 1 0 0 1 1 1 0 ThiF family Glyco_hydro_49N PF17433.2 KOS18751.1 - 5.2e-48 163.2 2.2 1e-47 162.2 2.2 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 49 N-terminal Ig-like domain Glyco_hydro_49 PF03718.13 KOS18751.1 - 1e-23 83.6 1.1 1.7e-23 82.8 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 49 IPU_b_solenoid PF18783.1 KOS18751.1 - 5.4e-19 67.9 1.1 5.4e-19 67.9 1.1 3.6 3 0 0 3 3 3 1 Isopullulanase beta-solenoid repeat B_solenoid_dext PF18841.1 KOS18751.1 - 6.7e-15 55.1 0.2 2.3e-14 53.4 0.2 2.0 1 0 0 1 1 1 1 Beta solenoid repeat from Dextranase Metallophos PF00149.28 KOS18754.1 - 2.1e-15 57.8 0.0 3.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 KOS18754.1 - 3e-11 44.0 0.2 9.9e-11 42.4 0.2 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 KOS18754.1 - 3.3e-09 37.2 0.0 8.6e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain EBV-NA3 PF05009.12 KOS18754.1 - 0.17 11.4 0.0 0.29 10.6 0.0 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) GGACT PF06094.12 KOS18755.1 - 1.3e-16 61.3 0.1 1.6e-16 61.0 0.1 1.1 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like Sec8_exocyst PF04048.14 KOS18756.1 - 8.2e-47 158.7 2.2 8.9e-47 158.6 0.5 2.0 2 0 0 2 2 2 1 Sec8 exocyst complex component specific domain Vps54_N PF10475.9 KOS18756.1 - 1.8e-10 40.6 1.9 3.5e-10 39.7 1.9 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Zw10 PF06248.13 KOS18756.1 - 9e-05 21.2 4.9 0.00039 19.1 4.7 2.0 1 1 1 2 2 2 1 Centromere/kinetochore Zw10 IZUMO PF15005.6 KOS18756.1 - 0.12 12.9 0.7 0.36 11.3 0.2 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Sec5 PF15469.6 KOS18756.1 - 0.24 11.2 1.4 0.49 10.2 1.4 1.5 1 0 0 1 1 1 0 Exocyst complex component Sec5 Hid1 PF12722.7 KOS18757.1 - 8.6e-262 870.9 0.0 3e-218 726.9 0.0 2.0 1 1 1 2 2 2 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 KOS18757.1 - 9.3e-85 285.3 0.0 1.2e-84 285.0 0.0 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF3246 PF11596.8 KOS18757.1 - 0.083 12.3 6.0 0.19 11.1 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) DNA_pol_phi PF04931.13 KOS18757.1 - 0.54 8.3 3.8 0.87 7.6 3.8 1.3 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 KOS18757.1 - 2 8.1 8.3 3.1 7.4 8.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 KOS18757.1 - 8.1 5.7 8.6 12 5.0 8.6 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 KOS18757.1 - 9.3 4.4 6.0 14 3.8 6.0 1.2 1 0 0 1 1 1 0 CDC45-like protein RCC1_2 PF13540.6 KOS18758.1 - 4.6e-14 51.8 8.9 3.1e-08 33.2 1.1 3.9 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 KOS18758.1 - 6.4e-13 49.1 8.5 3.7e-05 24.3 1.6 5.1 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat CPT PF07931.12 KOS18759.1 - 0.00041 20.2 0.0 0.00062 19.6 0.0 1.3 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 KOS18759.1 - 0.00058 20.4 0.0 0.0041 17.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 KOS18759.1 - 0.0038 17.5 0.0 0.0091 16.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 KOS18759.1 - 0.015 15.0 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 KOS18759.1 - 0.018 15.5 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOS18759.1 - 0.018 15.3 0.0 0.033 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 KOS18759.1 - 0.065 13.0 0.1 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 Cytidylate kinase TMEM154 PF15102.6 KOS18761.1 - 0.015 15.2 0.1 0.027 14.4 0.1 1.4 1 0 0 1 1 1 0 TMEM154 protein family SIT PF15330.6 KOS18761.1 - 0.14 12.6 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT SLC3A2_N PF16028.5 KOS18761.1 - 0.19 11.3 0.2 0.32 10.6 0.2 1.3 1 0 0 1 1 1 0 Solute carrier family 3 member 2 N-terminus Protocadherin PF08374.11 KOS18761.1 - 0.37 10.8 2.6 0.24 11.4 0.7 1.6 1 1 1 2 2 2 0 Protocadherin Zn_clus PF00172.18 KOS18762.1 - 2.5e-13 49.9 29.6 1.9e-07 31.1 12.6 2.6 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOS18762.1 - 2.5e-10 39.8 0.1 4e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF1451 PF07295.11 KOS18762.1 - 0.68 10.0 4.5 1.5 8.9 3.8 1.9 2 0 0 2 2 2 0 Zinc-ribbon containing domain zf-C2H2 PF00096.26 KOS18764.1 - 6.4e-07 29.5 18.9 9e-06 25.9 3.0 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS18764.1 - 1.7e-05 25.1 5.6 3.1e-05 24.2 2.6 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS18764.1 - 4.5e-05 23.9 1.8 4.5e-05 23.9 1.8 3.5 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOS18764.1 - 0.00015 21.7 1.3 0.00034 20.5 1.3 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOS18764.1 - 0.00036 20.8 0.5 0.00036 20.8 0.5 2.6 3 0 0 3 3 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_8 PF15909.5 KOS18764.1 - 0.0022 18.2 3.0 0.0045 17.2 3.0 1.5 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-met PF12874.7 KOS18764.1 - 0.0026 18.1 1.0 0.032 14.6 0.5 2.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type FOXP-CC PF16159.5 KOS18764.1 - 0.26 11.9 7.0 0.9 10.2 0.4 2.9 1 1 2 3 3 3 0 FOXP coiled-coil domain Yuri_gagarin PF15934.5 KOS18764.1 - 0.32 10.8 0.7 2.4 7.9 0.1 2.0 2 0 0 2 2 2 0 Yuri gagarin Zap1_zf2 PF18217.1 KOS18764.1 - 0.96 9.5 4.3 9.1 6.4 0.8 2.8 2 0 0 2 2 2 0 Zap1 zinc finger 2 zf-C2H2_aberr PF17017.5 KOS18764.1 - 1.1 9.4 3.3 2.6 8.2 3.3 1.6 1 1 0 1 1 1 0 Aberrant zinc-finger zf-C2H2_2 PF12756.7 KOS18764.1 - 2.6 8.4 5.0 7.9 6.9 3.8 2.4 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Stb3 PF10330.9 KOS18765.1 - 5.3e-37 125.7 0.0 9e-37 125.0 0.0 1.3 1 0 0 1 1 1 1 Putative Sin3 binding protein SF1-HH PF16275.5 KOS18765.1 - 0.049 14.0 0.0 0.09 13.1 0.0 1.3 1 0 0 1 1 1 0 Splicing factor 1 helix-hairpin domain Topoisom_bac PF01131.20 KOS18766.1 - 1e-103 347.5 0.0 1e-98 331.1 0.0 2.1 2 0 0 2 2 2 2 DNA topoisomerase Toprim PF01751.22 KOS18766.1 - 1.6e-17 63.6 0.0 3.5e-17 62.5 0.0 1.6 1 0 0 1 1 1 1 Toprim domain DUF1295 PF06966.12 KOS18767.1 - 1.4e-39 136.0 6.7 1.7e-39 135.7 6.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOS18767.1 - 0.24 11.9 2.2 0.43 11.0 0.1 2.4 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Hydrolase_6 PF13344.6 KOS18768.1 - 4.3e-16 58.9 0.0 7.4e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS18768.1 - 3e-13 49.6 0.1 6.2e-13 48.6 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOS18768.1 - 4.8e-06 27.0 0.0 0.00032 21.0 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOS18768.1 - 0.082 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase TPR_1 PF00515.28 KOS18770.1 - 2.4e-38 128.4 22.2 1.5e-07 30.9 0.3 10.3 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18770.1 - 7.2e-37 122.5 28.5 2.3e-06 27.2 0.2 11.3 12 0 0 12 12 12 7 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS18770.1 - 3.7e-29 100.8 16.9 2.1e-20 72.7 0.0 5.8 5 1 0 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 KOS18770.1 - 5.4e-26 88.6 14.8 0.029 14.6 0.0 11.4 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_19 PF14559.6 KOS18770.1 - 9.2e-26 90.2 20.2 3.4e-05 24.3 3.7 7.1 6 2 1 7 7 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOS18770.1 - 8e-25 85.4 26.9 0.0029 18.3 0.5 10.7 5 2 6 11 11 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18770.1 - 1.7e-21 76.6 32.2 2.9e-09 37.4 1.3 7.9 7 1 0 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 KOS18770.1 - 5.1e-20 71.6 27.4 0.00044 20.5 0.5 8.6 6 3 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 KOS18770.1 - 3.3e-18 64.3 14.1 0.002 18.0 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 KOS18770.1 - 2.4e-17 62.3 23.9 9.7e-07 28.4 1.5 8.7 7 2 3 10 10 10 4 TPR repeat TPR_17 PF13431.6 KOS18770.1 - 3.6e-17 61.4 15.2 0.034 14.5 0.2 10.1 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.6 KOS18770.1 - 4.4e-11 42.7 26.6 0.021 15.5 0.0 11.2 12 0 0 12 12 11 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS18770.1 - 1e-07 32.0 14.7 0.0092 16.1 0.1 5.7 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOS18770.1 - 4.8e-07 29.3 16.5 0.021 14.1 3.8 4.9 3 2 0 4 4 4 3 Tetratricopeptide repeat YfiO PF13525.6 KOS18770.1 - 0.00022 21.0 2.9 0.048 13.4 0.1 3.3 3 0 0 3 3 3 1 Outer membrane lipoprotein TPR_4 PF07721.14 KOS18770.1 - 0.00029 21.2 15.5 0.17 12.6 0.2 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 KOS18770.1 - 0.0048 17.2 8.8 0.034 14.5 1.5 4.2 4 1 0 4 4 3 1 Tetratricopeptide repeat TOM20_plant PF06552.12 KOS18770.1 - 0.032 14.0 0.9 21 4.8 0.0 3.8 2 1 1 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 DUF2225 PF09986.9 KOS18770.1 - 0.11 12.2 1.5 5.1 6.8 0.2 3.1 2 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Fis1_TPR_C PF14853.6 KOS18770.1 - 0.27 11.3 7.1 11 6.2 0.0 4.7 5 1 1 6 6 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 KOS18770.1 - 0.8 9.7 19.8 3.1 7.8 0.5 6.9 6 2 2 8 8 8 0 Tetratricopeptide repeat CENP-T_C PF15511.6 KOS18771.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 KOS18771.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 KOS18771.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 KOS18771.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 KOS18771.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 KOS18771.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOS18771.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KOS18771.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 KOS18771.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region RRM_1 PF00076.22 KOS18772.1 - 1.4e-12 47.2 0.0 3.8e-12 45.8 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup88 PF10168.9 KOS18773.1 - 1.6e-08 32.8 0.3 0.00039 18.4 0.0 2.7 2 1 0 2 2 2 2 Nuclear pore component APG17 PF04108.12 KOS18773.1 - 0.064 12.4 0.4 0.12 11.4 0.4 1.3 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF1116 PF06545.11 KOS18773.1 - 0.19 11.2 0.9 0.34 10.3 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1116) Gp-FAR-1 PF05823.12 KOS18773.1 - 0.19 12.1 0.1 0.51 10.7 0.1 1.7 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Nup54 PF13874.6 KOS18773.1 - 0.26 11.4 9.4 1.5 8.9 9.2 2.3 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Cep57_CLD PF14073.6 KOS18773.1 - 2.4 8.1 8.1 0.27 11.2 1.5 2.2 1 1 0 2 2 2 0 Centrosome localisation domain of Cep57 Sedlin_N PF04628.13 KOS18774.1 - 6.1e-43 146.1 0.0 6.9e-43 145.9 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 KOS18774.1 - 0.00017 21.5 0.0 0.0047 16.9 0.0 2.1 2 0 0 2 2 2 1 Sybindin-like family DUF5481 PF17578.2 KOS18774.1 - 0.13 12.7 0.0 0.2 12.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5481) L31 PF09784.9 KOS18775.1 - 1.7e-45 153.6 0.8 1.9e-45 153.4 0.8 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L31 Histone_HNS PF00816.21 KOS18775.1 - 0.066 14.0 0.9 0.08 13.8 0.9 1.1 1 0 0 1 1 1 0 H-NS histone family PrpF PF04303.13 KOS18776.1 - 6.8e-76 255.6 0.0 7.7e-76 255.5 0.0 1.0 1 0 0 1 1 1 1 PrpF protein AdoHcyase PF05221.17 KOS18777.1 - 1.6e-127 424.8 0.0 1.5e-73 247.6 0.3 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 KOS18777.1 - 6.5e-83 276.6 2.4 1.1e-82 275.9 2.4 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOS18777.1 - 4.3e-06 26.2 0.1 8.4e-06 25.3 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 KOS18777.1 - 0.035 13.7 0.7 0.068 12.7 0.7 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain ELFV_dehydrog PF00208.21 KOS18777.1 - 0.047 13.4 0.1 0.088 12.5 0.1 1.6 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 KOS18777.1 - 0.066 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain EBP PF05241.12 KOS18778.1 - 5.5e-38 130.2 7.0 6.1e-38 130.1 7.0 1.0 1 0 0 1 1 1 1 Emopamil binding protein Lipase_GDSL_3 PF14606.6 KOS18779.1 - 0.23 11.6 0.0 0.53 10.4 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Fungal_trans PF04082.18 KOS18780.1 - 1.7e-08 33.8 0.1 2e-08 33.6 0.1 1.3 1 1 0 1 1 1 1 Fungal specific transcription factor domain Pex16 PF08610.10 KOS18781.1 - 4.7e-136 453.2 0.2 5.6e-136 453.0 0.2 1.1 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) SRR1 PF07985.12 KOS18782.1 - 5.7e-14 51.9 0.0 1.1e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 SRR1 Glyco_hydro_17 PF00332.18 KOS18783.1 - 4.6e-10 39.6 2.4 5.4e-08 32.8 0.8 2.3 1 1 1 2 2 2 2 Glycosyl hydrolases family 17 RAMP4 PF06624.12 KOS18783.1 - 0.093 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 zf-C2H2_4 PF13894.6 KOS18784.1 - 0.015 16.1 21.8 0.019 15.7 1.6 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS18784.1 - 0.036 14.5 1.1 0.036 14.5 1.1 3.6 2 1 1 3 3 3 0 Zinc finger, C2H2 type DUF1223 PF06764.11 KOS18784.1 - 0.18 11.8 0.7 0.28 11.2 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1223) ZZ PF00569.17 KOS18784.1 - 0.28 11.0 8.7 0.16 11.8 4.0 2.4 2 0 0 2 2 2 0 Zinc finger, ZZ type A2L_zn_ribbon PF08792.10 KOS18784.1 - 1 9.1 6.9 4.4 7.2 0.1 2.8 2 1 0 2 2 2 0 A2L zinc ribbon domain WD40 PF00400.32 KOS18785.1 - 1.3e-12 47.9 2.1 0.85 10.6 0.0 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18785.1 - 0.038 14.3 0.0 27 5.2 0.0 3.6 2 2 2 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Fungal_trans PF04082.18 KOS18786.1 - 3.3e-07 29.6 0.2 7.8e-07 28.4 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain SLATT_fungal PF18142.1 KOS18787.1 - 2.1e-24 85.8 1.1 3.2e-24 85.2 1.1 1.3 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain DUF4231 PF14015.6 KOS18787.1 - 0.078 13.5 0.1 0.13 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Glyco_hydro_28 PF00295.17 KOS18788.1 - 6.5e-34 117.4 2.4 9.6e-34 116.9 2.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 KOS18788.1 - 0.017 15.0 7.2 0.063 13.1 5.7 2.1 1 1 1 2 2 2 0 Right handed beta helix region p450 PF00067.22 KOS18789.1 - 8.3e-57 192.9 0.0 1e-56 192.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 SKIP_SNW PF02731.15 KOS18790.1 - 9.4e-69 230.2 6.7 9.4e-69 230.2 6.7 2.8 3 0 0 3 3 3 1 SKIP/SNW domain PI3K_1B_p101 PF10486.9 KOS18790.1 - 0.046 11.5 12.1 0.061 11.1 12.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit HUN PF08729.10 KOS18790.1 - 0.13 12.3 1.2 0.37 10.8 1.2 1.8 1 0 0 1 1 1 0 HPC2 and ubinuclein domain COMPASS-Shg1 PF05205.12 KOS18791.1 - 1.5e-24 86.6 0.0 1.5e-24 86.6 0.0 2.6 3 0 0 3 3 3 1 COMPASS (Complex proteins associated with Set1p) component shg1 Med6 PF04934.14 KOS18792.1 - 4.1e-38 130.2 0.0 5.7e-38 129.7 0.0 1.2 1 0 0 1 1 1 1 MED6 mediator sub complex component ORC6 PF05460.13 KOS18792.1 - 2.8 7.1 6.7 3.8 6.7 6.7 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) HA2 PF04408.23 KOS18793.1 - 1.1e-22 80.3 0.0 1.1e-22 80.3 0.0 3.1 3 1 0 3 3 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOS18793.1 - 2e-11 44.2 0.0 6.8e-11 42.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOS18793.1 - 1.9e-09 37.7 0.0 4.9e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOS18793.1 - 8.5e-08 32.2 0.1 2.3e-07 30.8 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOS18793.1 - 0.00019 21.7 0.0 0.00061 20.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS18793.1 - 0.00055 20.3 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS18793.1 - 0.0019 17.9 1.7 0.0033 17.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 KOS18793.1 - 0.0068 15.5 0.0 0.015 14.3 0.0 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein PhoH PF02562.16 KOS18793.1 - 0.013 15.0 0.0 0.028 13.9 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 KOS18793.1 - 0.041 13.2 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF2075 PF09848.9 KOS18793.1 - 0.068 12.4 0.9 0.12 11.5 0.0 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_23 PF13476.6 KOS18793.1 - 0.07 13.6 0.0 0.07 13.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 KOS18793.1 - 0.11 11.8 0.2 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family PhoD PF09423.10 KOS18794.1 - 3e-41 141.6 0.0 4.4e-41 141.0 0.0 1.2 1 0 0 1 1 1 1 PhoD-like phosphatase Rrp15p PF07890.12 KOS18795.1 - 1.8e-38 131.9 7.0 1.8e-38 131.9 7.0 3.3 2 1 0 2 2 2 1 Rrp15p Cnd2 PF05786.14 KOS18795.1 - 0.0033 16.2 11.6 0.0033 16.2 11.6 2.1 1 1 1 2 2 2 1 Condensin complex subunit 2 Fer2 PF00111.27 KOS18796.1 - 2.3e-13 49.9 0.7 2.7e-13 49.7 0.7 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain AKAP7_NLS PF10469.9 KOS18797.1 - 4.3e-28 98.6 0.0 7.5e-28 97.8 0.0 1.4 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain Lebercilin PF15619.6 KOS18798.1 - 0.072 12.7 13.9 0.033 13.9 3.2 2.8 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Golgin_A5 PF09787.9 KOS18798.1 - 0.072 12.5 8.9 0.012 15.1 4.6 1.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 SUIM_assoc PF16619.5 KOS18798.1 - 0.092 12.8 3.0 0.1 12.7 1.0 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 V_ATPase_I PF01496.19 KOS18798.1 - 0.16 9.8 3.7 0.12 10.2 0.4 1.9 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Csm1_N PF18504.1 KOS18798.1 - 0.29 11.5 0.1 0.29 11.5 0.1 3.2 3 1 1 4 4 4 0 Csm1 N-terminal domain BORG_CEP PF14957.6 KOS18798.1 - 0.32 12.1 1.7 0.69 11.1 0.0 2.2 2 1 0 2 2 2 0 Cdc42 effector DUF2196 PF09962.9 KOS18800.1 - 4e-23 81.1 0.5 5.8e-23 80.6 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2196) Sugar_tr PF00083.24 KOS18801.1 - 8.9e-100 334.7 17.0 1e-99 334.5 17.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS18801.1 - 1.2e-16 60.6 38.3 1.2e-16 60.6 38.3 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 KOS18802.1 - 7.3e-54 182.9 0.0 9.6e-54 182.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18802.1 - 2.4e-25 89.3 0.0 3.5e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS18802.1 - 1.8e-06 27.5 0.0 2.5e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS18802.1 - 0.0076 16.2 2.6 0.54 10.1 0.0 3.2 4 0 0 4 4 4 1 Phosphotransferase enzyme family Kdo PF06293.14 KOS18802.1 - 0.043 13.2 0.0 0.072 12.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-ANAPC11 PF12861.7 KOS18803.1 - 2.1e-31 107.8 3.1 2.3e-31 107.7 3.1 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 KOS18803.1 - 1.3e-12 47.8 4.4 1.9e-12 47.2 4.4 1.2 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-HIT PF04438.16 KOS18803.1 - 0.058 13.3 0.9 0.058 13.3 0.9 1.5 2 0 0 2 2 2 0 HIT zinc finger zf-RING_2 PF13639.6 KOS18803.1 - 1.8 9.0 9.9 53 4.3 9.9 2.5 1 1 0 1 1 1 0 Ring finger domain Ribosomal_L31e PF01198.19 KOS18804.1 - 2.1e-39 133.6 2.1 2.9e-39 133.1 2.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e UQ_con PF00179.26 KOS18805.1 - 4.2e-42 143.1 0.0 3.5e-39 133.7 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS18805.1 - 0.00013 21.7 0.0 0.00024 20.8 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOS18805.1 - 0.0018 18.5 0.0 0.0022 18.2 0.0 1.3 1 0 0 1 1 1 1 RWD domain UEV PF05743.13 KOS18805.1 - 0.0075 16.1 0.0 0.013 15.4 0.0 1.4 1 1 0 1 1 1 1 UEV domain Rhodanese PF00581.20 KOS18806.1 - 8.4e-18 64.9 0.0 1.7e-09 38.2 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain HAD_2 PF13419.6 KOS18806.1 - 0.03 14.4 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Ribosomal_S5 PF00333.20 KOS18807.1 - 2.1e-27 94.9 1.0 5.1e-27 93.7 1.0 1.7 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 KOS18807.1 - 8.2e-23 79.6 0.0 1.3e-22 79.0 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain FoP_duplication PF13865.6 KOS18807.1 - 3.4 8.3 18.3 8.7 7.0 18.3 1.6 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 RXT2_N PF08595.11 KOS18808.1 - 0.098 12.7 2.6 0.1 12.6 2.6 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 KOS18808.1 - 0.13 11.6 6.3 0.13 11.6 6.3 1.0 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 KOS18808.1 - 0.21 11.2 2.6 0.24 11.1 2.6 1.1 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 KOS18808.1 - 0.31 9.1 3.5 0.29 9.2 3.5 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 KOS18808.1 - 8.7 6.8 14.6 11 6.4 14.6 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain HAMP PF00672.25 KOS18809.1 - 2.2e-40 136.8 18.1 2.4e-08 34.2 0.0 8.2 7 1 0 7 7 7 5 HAMP domain HATPase_c PF02518.26 KOS18809.1 - 1.2e-29 103.0 0.0 5.3e-29 101.0 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS18809.1 - 1.2e-27 96.2 0.5 1.3e-25 89.7 0.3 3.1 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 KOS18809.1 - 3e-17 62.4 4.8 8.9e-17 60.9 0.5 4.0 3 1 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Syntaxin_2 PF14523.6 KOS18809.1 - 1.4e-07 31.8 11.4 6 7.3 0.0 7.7 2 2 2 6 6 6 2 Syntaxin-like protein DUF4279 PF14106.6 KOS18809.1 - 0.00078 19.6 0.0 34 4.7 0.0 5.2 6 0 0 6 6 5 0 Domain of unknown function (DUF4279) DUF3829 PF12889.7 KOS18809.1 - 0.0045 16.5 10.5 0.89 9.0 0.1 4.8 4 2 1 5 5 5 2 Protein of unknown function (DUF3829) Fib_alpha PF08702.10 KOS18809.1 - 0.0069 16.6 33.2 0.61 10.3 0.2 7.0 7 0 0 7 7 7 2 Fibrinogen alpha/beta chain family DUF4795 PF16043.5 KOS18809.1 - 0.011 15.3 27.3 1.5 8.4 0.3 6.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4795) DUF883 PF05957.13 KOS18809.1 - 0.012 16.2 11.5 2.4 8.8 0.2 6.0 3 2 2 6 6 6 0 Bacterial protein of unknown function (DUF883) DUF948 PF06103.11 KOS18809.1 - 0.014 15.6 49.1 2.1 8.7 2.6 10.8 4 2 3 7 7 7 0 Bacterial protein of unknown function (DUF948) IL32 PF15225.6 KOS18809.1 - 0.12 12.8 0.0 13 6.2 0.0 4.0 5 0 0 5 5 4 0 Interleukin 32 PMC2NT PF08066.12 KOS18809.1 - 0.18 12.5 11.4 2 9.2 1.9 6.0 5 1 0 5 5 5 0 PMC2NT (NUC016) domain GhoS PF11080.8 KOS18809.1 - 0.29 11.1 7.6 0.6 10.1 0.1 4.0 4 0 0 4 4 4 0 Endoribonuclease GhoS GLE1 PF07817.13 KOS18809.1 - 0.4 9.8 7.8 14 4.7 0.1 4.4 3 1 2 5 5 5 0 GLE1-like protein BORCS6 PF10157.9 KOS18809.1 - 2 8.6 14.4 6.8 6.9 0.1 5.9 3 3 2 5 5 5 0 BLOC-1-related complex sub-unit 6 UBD PF16455.5 KOS18809.1 - 2.5 8.4 4.8 8.2 6.7 0.1 3.1 3 0 0 3 3 2 0 Ubiquitin-binding domain GatB_Yqey PF02637.18 KOS18809.1 - 3.4 7.5 8.9 0.31 10.9 0.1 3.7 5 0 0 5 5 4 0 GatB domain FAM184 PF15665.5 KOS18809.1 - 3.9 7.2 17.6 2.3 7.9 0.9 4.2 4 1 0 4 4 4 0 Family with sequence similarity 184, A and B KxDL PF10241.9 KOS18810.1 - 0.081 13.2 0.1 0.1 12.9 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein Cnd2 PF05786.14 KOS18812.1 - 0 1037.4 9.8 0 1037.2 9.8 1.0 1 0 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 KOS18812.1 - 0.033 14.4 1.4 0.32 11.2 0.0 2.6 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Na_Ca_ex PF01699.24 KOS18813.1 - 7.7e-49 165.5 37.0 4.5e-27 94.9 17.7 3.2 4 0 0 4 4 4 2 Sodium/calcium exchanger protein Herpes_gE PF02480.16 KOS18813.1 - 0.0031 16.3 0.3 0.78 8.4 0.0 2.2 2 0 0 2 2 2 2 Alphaherpesvirus glycoprotein E MARVEL PF01284.23 KOS18813.1 - 0.0038 17.3 1.1 0.0038 17.3 1.1 4.4 4 1 1 5 5 5 2 Membrane-associating domain DUF1590 PF07629.11 KOS18813.1 - 0.31 10.9 1.8 0.69 9.8 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1590) PMM PF03332.13 KOS18814.1 - 4e-103 343.9 0.0 5e-103 343.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 KOS18814.1 - 0.012 15.3 0.0 0.24 11.1 0.0 2.0 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS18814.1 - 0.034 14.5 0.0 8.6 6.7 0.0 2.7 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase WW PF00397.26 KOS18815.1 - 1.2e-11 44.5 0.1 4e-11 42.8 0.1 2.0 1 0 0 1 1 1 1 WW domain PhoD PF09423.10 KOS18815.1 - 8.1e-05 21.8 1.7 0.0041 16.2 0.4 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase MutS_V PF00488.21 KOS18816.1 - 7.8e-74 247.8 0.1 1.6e-73 246.8 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOS18816.1 - 1.9e-35 122.8 0.8 4.1e-35 121.7 0.8 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOS18816.1 - 4.6e-29 100.9 0.0 1e-28 99.8 0.0 1.6 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 KOS18816.1 - 2.3e-09 37.7 0.0 9.6e-09 35.6 0.0 2.1 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 KOS18816.1 - 0.00048 20.4 0.0 0.0014 19.0 0.0 1.7 1 0 0 1 1 1 1 MutS family domain IV DUF4911 PF16256.5 KOS18816.1 - 0.0028 17.6 0.0 0.006 16.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4911) PRTP PF01366.18 KOS18816.1 - 0.045 11.8 0.0 0.069 11.2 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus processing and transport protein AAA_27 PF13514.6 KOS18816.1 - 0.12 12.0 0.0 0.3 10.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 KOS18816.1 - 0.15 11.8 0.0 0.37 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Herpes_LMP1 PF05297.11 KOS18816.1 - 4.1 6.5 5.5 7.2 5.7 5.5 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sigma70_ner PF04546.13 KOS18816.1 - 8.9 6.1 7.6 6.4 6.6 2.7 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region Prenyltrans PF00432.21 KOS18817.1 - 4e-58 192.8 17.6 1.3e-11 44.0 0.0 6.1 6 0 0 6 6 6 6 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KOS18817.1 - 5e-05 22.5 0.0 0.11 11.6 0.0 3.5 2 1 2 4 4 4 3 Squalene-hopene cyclase N-terminal domain SQHop_cyclase_C PF13243.6 KOS18817.1 - 0.00092 18.4 0.2 0.058 12.5 0.0 2.8 1 1 2 3 3 3 1 Squalene-hopene cyclase C-terminal domain BAH PF01426.18 KOS18818.1 - 1e-17 64.1 0.0 2.7e-17 62.8 0.0 1.7 1 0 0 1 1 1 1 BAH domain zf-HC5HC2H_2 PF13832.6 KOS18818.1 - 5.8e-07 29.7 0.7 4.5e-06 26.8 0.0 2.6 3 0 0 3 3 3 1 PHD-zinc-finger like domain Myb_DNA-binding PF00249.31 KOS18818.1 - 0.023 14.9 0.0 0.093 12.9 0.0 2.1 2 0 0 2 2 2 0 Myb-like DNA-binding domain Pkinase PF00069.25 KOS18819.1 - 1e-33 116.9 0.0 4.4e-18 65.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18819.1 - 3.9e-13 49.3 0.0 9.2e-11 41.5 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KOS18819.1 - 0.0024 17.8 0.1 0.0058 16.6 0.0 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 KOS18819.1 - 0.0069 15.7 0.0 3 7.1 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Cupin_8 PF13621.6 KOS18820.1 - 2.2e-19 70.2 0.0 1.9e-17 63.9 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOS18820.1 - 8.4e-11 42.3 0.0 3.7e-10 40.2 0.0 2.1 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 KOS18820.1 - 5.4e-09 35.8 0.1 5.4e-09 35.8 0.1 2.2 3 0 0 3 3 3 1 F-box-like F-box PF00646.33 KOS18820.1 - 1.5e-07 31.1 0.0 4.2e-07 29.7 0.0 1.8 1 0 0 1 1 1 1 F-box domain Elongin_A PF06881.11 KOS18820.1 - 0.0068 16.9 0.0 0.012 16.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A Cupin_4 PF08007.12 KOS18820.1 - 0.12 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin superfamily protein TT_ORF2 PF02957.15 KOS18820.1 - 0.45 11.4 1.5 0.85 10.5 1.5 1.4 1 0 0 1 1 1 0 TT viral ORF2 DUF1771 PF08590.10 KOS18821.1 - 1.8e-15 57.1 11.8 1.5e-14 54.1 10.9 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1771) zf_CCCH_4 PF18345.1 KOS18821.1 - 2.4e-07 30.6 8.0 4.3e-06 26.6 0.6 2.9 2 1 0 2 2 2 2 Zinc finger domain Smr PF01713.21 KOS18821.1 - 1.5e-06 28.5 0.0 3.4e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Smr domain zf-CCCH PF00642.24 KOS18821.1 - 1e-05 25.3 4.4 0.0062 16.4 0.7 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 KOS18821.1 - 0.0013 19.1 6.0 0.53 10.8 0.2 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 KOS18821.1 - 0.0014 18.4 0.4 0.0014 18.4 0.4 3.0 2 1 0 2 2 2 1 CCCH-type zinc finger HBS1_N PF08938.10 KOS18821.1 - 0.017 15.4 0.0 0.044 14.1 0.0 1.6 1 0 0 1 1 1 0 HBS1 N-terminus Torus PF16131.5 KOS18821.1 - 0.17 12.6 3.1 0.67 10.7 3.1 1.8 1 1 0 1 1 1 0 Torus domain zf-CCCH_3 PF15663.5 KOS18821.1 - 1.6 9.0 4.2 17 5.7 0.3 2.3 1 1 1 2 2 2 0 Zinc-finger containing family MARVEL PF01284.23 KOS18822.1 - 0.016 15.2 14.4 0.029 14.4 13.6 1.7 1 1 1 2 2 2 0 Membrane-associating domain DUF4064 PF13273.6 KOS18822.1 - 1.4 9.2 7.9 5.8e+02 0.8 8.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) DEAD PF00270.29 KOS18823.1 - 6.7e-45 153.0 1.2 1.1e-44 152.3 1.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS18823.1 - 4.6e-32 110.7 0.2 8.8e-31 106.5 0.0 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS18823.1 - 1.1e-05 25.5 0.0 1.9e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 KOS18823.1 - 0.00046 20.0 0.1 0.00088 19.0 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS18823.1 - 0.00055 20.3 1.2 0.0031 17.9 0.4 2.2 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS18823.1 - 0.011 16.0 0.5 0.047 14.0 0.5 2.1 1 1 0 1 1 1 0 AAA domain IL17R_D_N PF16742.5 KOS18823.1 - 0.03 14.4 0.0 0.08 13.0 0.0 1.7 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D Flavi_DEAD PF07652.14 KOS18823.1 - 0.055 13.5 0.0 0.25 11.3 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain UvrD-helicase PF00580.21 KOS18823.1 - 0.078 12.5 0.3 0.23 10.9 0.3 1.4 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 KOS18823.1 - 0.091 12.6 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Helicase fragilysinNterm PF16376.5 KOS18823.1 - 0.11 12.3 0.0 0.32 10.7 0.0 1.8 1 0 0 1 1 1 0 N-terminal domain of fragilysin Abhydrolase_1 PF00561.20 KOS18824.1 - 1.9e-12 47.4 0.1 5.9e-12 45.8 0.1 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS18824.1 - 5e-08 32.5 0.1 1.1e-07 31.4 0.1 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S28 PF05577.12 KOS18824.1 - 0.12 11.2 0.0 0.38 9.5 0.0 1.7 1 1 0 1 1 1 0 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 KOS18824.1 - 0.2 11.1 0.0 0.38 10.2 0.0 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family DEAD PF00270.29 KOS18825.1 - 8.9e-10 38.6 1.0 3.6e-06 26.9 0.1 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase HHH_5 PF14520.6 KOS18825.1 - 0.00068 20.2 0.0 0.0022 18.6 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain Spo0A_C PF08769.11 KOS18825.1 - 0.087 12.9 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Sporulation initiation factor Spo0A C terminal SNARE_assoc PF09335.11 KOS18826.1 - 1.2e-14 54.8 4.2 1.2e-14 54.8 4.2 2.6 3 0 0 3 3 3 1 SNARE associated Golgi protein ATG16 PF08614.11 KOS18827.1 - 2.5 8.3 5.0 0.52 10.5 0.5 2.0 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Neurochondrin PF05536.11 KOS18828.1 - 3.6e-83 280.0 0.1 5.9e-83 279.2 0.1 1.3 1 1 0 1 1 1 1 Neurochondrin RIX1 PF08167.12 KOS18828.1 - 1e-05 25.4 1.8 0.00015 21.6 0.5 2.9 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis SUIM_assoc PF16619.5 KOS18828.1 - 0.0027 17.7 0.7 0.0099 15.9 0.8 1.9 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF241 PF03087.14 KOS18829.1 - 0.09 12.6 0.0 0.09 12.6 0.0 2.4 3 0 0 3 3 3 0 Arabidopsis protein of unknown function Ras PF00071.22 KOS18830.1 - 1.9e-34 118.6 0.0 2.5e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS18830.1 - 1.3e-09 38.3 0.0 1.9e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RRM_1 PF00076.22 KOS18831.1 - 8.8e-40 134.4 0.1 1.4e-12 47.2 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS18831.1 - 2.6e-16 59.2 0.0 0.0079 16.0 0.0 4.3 4 0 0 4 4 4 4 Occluded RNA-recognition motif RRM PF10378.9 KOS18831.1 - 1.4e-08 34.3 3.6 1.4e-08 34.3 3.6 3.0 3 0 0 3 3 3 1 Putative RRM domain RRM_7 PF16367.5 KOS18831.1 - 1.4e-05 25.1 0.0 0.099 12.8 0.0 3.9 3 0 0 3 3 3 1 RNA recognition motif DUF4523 PF15023.6 KOS18831.1 - 2.5e-05 24.2 0.0 0.14 12.0 0.0 3.2 3 0 0 3 3 3 2 Protein of unknown function (DUF4523) RRM_Rrp7 PF17799.1 KOS18831.1 - 0.0061 16.4 0.1 0.83 9.4 0.0 3.9 3 1 1 4 4 4 1 Rrp7 RRM-like N-terminal domain Nup35_RRM_2 PF14605.6 KOS18831.1 - 0.0064 16.5 0.0 2.2 8.3 0.0 3.3 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOS18831.1 - 0.0069 16.4 0.1 0.26 11.3 0.1 2.9 3 0 0 3 3 3 1 RNA binding motif CHASE8 PF17152.4 KOS18831.1 - 0.08 13.2 0.9 37 4.6 0.8 3.2 3 0 0 3 3 3 0 Periplasmic sensor domain RNA_bind PF08675.11 KOS18831.1 - 0.11 12.6 0.5 0.57 10.2 0.0 2.5 3 0 0 3 3 3 0 RNA binding domain His_Phos_2 PF00328.22 KOS18832.1 - 3.3e-13 49.7 0.0 9e-11 41.7 0.0 2.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 2) Abhydrolase_6 PF12697.7 KOS18834.1 - 0.00036 21.2 1.1 0.00036 21.2 1.1 1.8 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF676 PF05057.14 KOS18834.1 - 0.016 14.7 0.0 0.037 13.5 0.0 1.5 2 0 0 2 2 2 0 Putative serine esterase (DUF676) LCAT PF02450.15 KOS18834.1 - 0.061 12.5 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase Hydrolase_4 PF12146.8 KOS18834.1 - 0.08 12.2 0.1 0.24 10.6 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DNA_ligase_A_M PF01068.21 KOS18836.1 - 8.1e-62 208.5 0.3 8.6e-49 166.0 0.1 2.3 1 1 1 2 2 2 2 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOS18836.1 - 9.3e-40 136.8 0.8 1.9e-39 135.7 0.0 2.0 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 KOS18836.1 - 3.1e-29 101.5 0.6 9.7e-29 99.9 0.0 2.3 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 KOS18836.1 - 7.1e-05 23.2 0.1 0.00011 22.5 0.1 1.3 1 0 0 1 1 1 1 RNA ligase Presenilin PF01080.17 KOS18836.1 - 0.071 11.9 5.0 0.12 11.1 5.0 1.4 1 0 0 1 1 1 0 Presenilin Dicty_REP PF05086.12 KOS18836.1 - 0.23 9.4 11.6 0.32 8.9 11.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 KOS18836.1 - 0.42 10.6 6.8 1.3 9.0 6.8 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein PGA_cap PF09587.10 KOS18836.1 - 2.8 7.3 5.0 5.5 6.4 5.0 1.5 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap SAPS PF04499.15 KOS18836.1 - 6.7 5.4 7.5 10 4.8 7.5 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Voltage_CLC PF00654.20 KOS18837.1 - 3.5e-88 296.2 25.4 5.7e-88 295.5 25.4 1.3 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 KOS18837.1 - 0.022 15.2 0.0 0.65 10.5 0.0 2.5 2 0 0 2 2 2 0 CBS domain DUF2052 PF09747.9 KOS18838.1 - 3.7e-25 89.2 11.3 4.7e-23 82.4 11.3 2.0 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Piwi PF02171.17 KOS18839.1 - 3e-65 220.4 0.0 4.4e-65 219.9 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 KOS18839.1 - 1.6e-15 58.0 0.1 3.1e-15 57.0 0.1 1.5 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL1 PF08699.10 KOS18839.1 - 1.8e-13 50.0 0.2 3.8e-13 48.9 0.2 1.6 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoL2 PF16488.5 KOS18839.1 - 2.1e-08 34.3 0.0 7.9e-08 32.5 0.0 2.1 2 0 0 2 2 2 1 Argonaute linker 2 domain PAZ PF02170.22 KOS18839.1 - 6.6e-08 32.4 0.0 2.8e-07 30.4 0.0 2.0 2 0 0 2 2 2 1 PAZ domain GFO_IDH_MocA PF01408.22 KOS18840.1 - 2.7e-18 66.9 0.1 5.9e-18 65.8 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Semialdhyde_dh PF01118.24 KOS18840.1 - 0.092 13.2 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Fungal_trans PF04082.18 KOS18841.1 - 1.9e-18 66.5 0.1 2.9e-18 65.9 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Gal4_dimer PF03902.13 KOS18841.1 - 0.028 14.6 0.3 0.063 13.4 0.3 1.5 1 0 0 1 1 1 0 Gal4-like dimerisation domain zf-C4pol PF14260.6 KOS18841.1 - 0.037 14.5 0.9 1.1 9.7 0.1 2.4 2 0 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta Sugar_tr PF00083.24 KOS18842.1 - 4e-86 289.7 16.6 4.6e-86 289.5 16.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS18842.1 - 7.3e-31 107.4 29.6 9.3e-29 100.4 19.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOS18842.1 - 0.0021 16.6 3.1 0.0021 16.6 3.1 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) adh_short_C2 PF13561.6 KOS18843.1 - 1e-56 192.1 0.1 1.6e-56 191.5 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS18843.1 - 8.3e-41 139.6 0.0 1.2e-40 139.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS18843.1 - 1.9e-12 47.5 0.2 3e-12 46.8 0.2 1.3 1 0 0 1 1 1 1 KR domain Mg_chelatase PF01078.21 KOS18843.1 - 0.0016 17.9 0.0 0.003 17.0 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI PRK PF00485.18 KOS18843.1 - 0.0021 17.9 0.0 0.21 11.3 0.0 2.4 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA PF00004.29 KOS18843.1 - 0.0028 18.1 0.0 0.005 17.3 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sacchrp_dh_NADP PF03435.18 KOS18843.1 - 0.0035 17.6 0.1 0.0065 16.7 0.1 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AAA_18 PF13238.6 KOS18843.1 - 0.0061 17.1 0.3 0.066 13.8 0.0 2.5 3 0 0 3 3 2 1 AAA domain Epimerase PF01370.21 KOS18843.1 - 0.0062 16.0 0.1 0.0094 15.4 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NTPase_1 PF03266.15 KOS18843.1 - 0.0064 16.4 0.1 0.037 13.9 0.0 2.1 2 0 0 2 2 2 1 NTPase AAA_33 PF13671.6 KOS18843.1 - 0.0078 16.4 0.2 0.068 13.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS18843.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS18843.1 - 0.016 15.6 0.0 0.032 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 KOS18843.1 - 0.016 14.4 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Zeta_toxin PF06414.12 KOS18843.1 - 0.03 13.6 0.1 0.096 12.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_25 PF13481.6 KOS18843.1 - 0.041 13.5 0.0 0.12 11.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS18843.1 - 0.053 13.4 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 KOS18843.1 - 0.055 13.8 0.0 0.19 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain 2-Hacid_dh_C PF02826.19 KOS18843.1 - 0.072 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AAA_5 PF07728.14 KOS18843.1 - 0.074 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_17 PF13207.6 KOS18843.1 - 0.089 13.2 0.2 0.81 10.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 KOS18843.1 - 0.096 13.2 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 ABC transporter GDP_Man_Dehyd PF16363.5 KOS18843.1 - 0.17 11.3 0.0 0.29 10.5 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase RuvB_N PF05496.12 KOS18843.1 - 0.18 11.6 0.0 0.47 10.2 0.0 1.6 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 KOS18843.1 - 0.19 11.7 0.0 0.31 11.0 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_11 PF13086.6 KOS18843.1 - 0.22 11.3 0.0 0.38 10.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain ADH_N PF08240.12 KOS18844.1 - 4.5e-32 110.2 0.8 4.5e-32 110.2 0.8 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS18844.1 - 9.5e-20 70.9 3.2 9.5e-20 70.9 3.2 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS18844.1 - 7.4e-07 30.3 0.1 4e-06 27.9 0.1 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS18844.1 - 8.1e-07 28.7 0.5 0.0047 16.4 0.0 2.4 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus Methyltransf_25 PF13649.6 KOS18844.1 - 0.0017 19.0 0.4 0.0035 18.0 0.4 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOS18844.1 - 0.012 14.9 0.0 0.018 14.3 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Hexapep PF00132.24 KOS18844.1 - 0.079 12.7 0.9 0.28 11.0 0.9 1.9 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) SopE_GEF PF07487.13 KOS18844.1 - 0.15 12.2 0.1 0.31 11.1 0.1 1.5 1 0 0 1 1 1 0 SopE GEF domain adh_short_C2 PF13561.6 KOS18845.1 - 4e-59 200.0 3.1 4.9e-59 199.7 3.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS18845.1 - 5.4e-44 150.0 0.7 7.1e-44 149.6 0.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS18845.1 - 6e-13 49.1 4.1 3e-12 46.8 4.2 1.9 1 1 0 1 1 1 1 KR domain Glyco_tranf_2_3 PF13641.6 KOS18845.1 - 0.011 15.7 0.3 0.02 14.8 0.3 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Epimerase PF01370.21 KOS18845.1 - 0.027 14.0 0.1 0.22 11.0 0.1 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Glyco_transf_4 PF13439.6 KOS18845.1 - 0.037 14.0 0.1 0.055 13.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 TetR_C_35 PF18556.1 KOS18845.1 - 0.074 13.2 0.8 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 Bacterial Tetracyclin repressor, C-terminal domain GDP_Man_Dehyd PF16363.5 KOS18845.1 - 0.22 10.9 0.0 0.4 10.0 0.0 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase CMD PF02627.20 KOS18845.1 - 0.83 9.7 6.4 1.8 8.7 0.7 2.8 1 1 1 2 2 2 0 Carboxymuconolactone decarboxylase family Response_reg PF00072.24 KOS18846.1 - 1.5e-21 76.7 0.0 3.7e-15 56.0 0.0 2.6 2 0 0 2 2 2 2 Response regulator receiver domain zf-trcl PF13451.6 KOS18847.1 - 3.1 7.8 5.8 3.3 7.7 0.4 2.6 3 0 0 3 3 3 0 Probable zinc-ribbon domain MFS_1 PF07690.16 KOS18848.1 - 1.2e-28 100.1 46.6 8.7e-26 90.7 29.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily CENP-B_dimeris PF09026.10 KOS18848.1 - 0.01 16.2 0.6 0.018 15.4 0.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sugar_tr PF00083.24 KOS18848.1 - 0.023 13.6 14.0 0.085 11.7 14.0 2.0 1 1 0 1 1 1 0 Sugar (and other) transporter CFEM PF05730.11 KOS18849.1 - 1e-13 51.2 5.9 1.2e-13 51.0 5.9 1.1 1 0 0 1 1 1 1 CFEM domain CAF1A PF12253.8 KOS18850.1 - 5.2e-21 74.6 5.0 5.2e-21 74.6 5.0 2.2 2 0 0 2 2 2 1 Chromatin assembly factor 1 subunit A MurB_C PF02873.16 KOS18850.1 - 0.032 14.3 2.0 0.13 12.3 0.4 2.5 2 1 0 2 2 2 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain Peptidase_S64 PF08192.11 KOS18850.1 - 0.081 11.4 2.6 0.1 11.0 2.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 OPT PF03169.15 KOS18852.1 - 2.2e-119 399.9 42.7 2.5e-119 399.7 42.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF1056 PF06341.11 KOS18852.1 - 0.11 12.9 0.0 0.11 12.9 0.0 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1056) SNARE_assoc PF09335.11 KOS18852.1 - 1.1 9.7 21.9 0.067 13.7 5.2 4.3 4 1 0 4 4 4 0 SNARE associated Golgi protein Phage_holin_5_2 PF16079.5 KOS18852.1 - 6 7.3 9.1 0.5 10.7 0.9 3.4 3 0 0 3 3 3 0 Phage holin family Hol44, in holin superfamily V 2-Hacid_dh_C PF02826.19 KOS18855.1 - 8e-52 175.2 0.0 1.8e-51 174.0 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOS18855.1 - 9.4e-17 60.9 0.0 1.4e-16 60.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOS18855.1 - 5.3e-05 23.4 0.1 0.00013 22.1 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 KOS18855.1 - 0.0017 17.7 0.1 0.29 10.4 0.0 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain EXS PF03124.14 KOS18856.1 - 5.8e-94 315.1 29.6 7.3e-94 314.8 29.6 1.1 1 0 0 1 1 1 1 EXS family SPX PF03105.19 KOS18856.1 - 4.2e-70 237.6 16.7 4.2e-70 237.6 16.7 2.2 2 1 0 2 2 2 1 SPX domain Peptidase_M18 PF02127.15 KOS18857.1 - 2.9e-115 385.5 0.0 3.7e-115 385.2 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) DZR PF12773.7 KOS18857.1 - 0.41 10.7 1.3 0.72 9.9 1.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon CENP-T_C PF15511.6 KOS18858.1 - 8e-09 35.6 0.1 9.7e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 KOS18858.1 - 2.4e-05 24.7 0.1 2.8e-05 24.5 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 KOS18858.1 - 7.2e-05 22.9 0.1 0.0001 22.4 0.1 1.3 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 KOS18858.1 - 0.0002 21.6 0.1 0.00035 20.8 0.0 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 KOS18858.1 - 0.0004 20.7 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 KOS18858.1 - 0.0085 16.2 0.0 0.01 15.9 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOS18858.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated UPF0137 PF03677.13 KOS18858.1 - 0.052 13.3 0.2 0.064 13.0 0.2 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0137) HIGH_NTase1_ass PF16581.5 KOS18858.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region zf-C2H2 PF00096.26 KOS18859.1 - 6e-06 26.4 7.1 0.051 14.0 3.5 3.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS18859.1 - 0.0066 17.2 4.1 4.7 8.3 2.4 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger ig PF00047.25 KOS18859.1 - 0.18 12.0 1.5 8.4 6.7 0.0 2.4 2 0 0 2 2 2 0 Immunoglobulin domain zf-Di19 PF05605.12 KOS18859.1 - 0.61 10.4 3.1 2.9 8.3 2.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Sacchrp_dh_C PF16653.5 KOS18860.1 - 3.9e-64 217.3 0.0 8.2e-64 216.3 0.0 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 KOS18860.1 - 4.3e-26 91.7 0.4 7.4e-26 90.9 0.4 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 KOS18860.1 - 0.00026 21.0 0.1 0.00053 20.1 0.1 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 KOS18860.1 - 0.0033 17.3 0.1 0.0054 16.6 0.1 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GFO_IDH_MocA PF01408.22 KOS18860.1 - 0.0056 17.5 0.0 0.011 16.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 KOS18860.1 - 0.02 15.5 0.2 0.042 14.5 0.2 1.5 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOS18860.1 - 0.023 14.0 0.2 0.036 13.3 0.2 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.12 KOS18860.1 - 0.031 13.9 0.1 0.088 12.4 0.0 1.8 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_N PF03721.14 KOS18860.1 - 0.072 12.6 0.3 0.15 11.6 0.3 1.5 1 1 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SieB PF14163.6 KOS18860.1 - 0.12 11.8 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 Super-infection exclusion protein B Histone PF00125.24 KOS18861.1 - 1.4e-51 174.2 2.2 1.6e-51 174.1 2.2 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 KOS18861.1 - 8.4e-06 26.1 0.0 1.3e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 KOS18861.1 - 3.5e-05 23.9 0.4 6.4e-05 23.0 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 KOS18861.1 - 4.7e-05 24.0 0.9 5.4e-05 23.8 0.9 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CBFD_NFYB_HMF PF00808.23 KOS18861.1 - 0.0036 17.5 0.0 0.0065 16.7 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 KOS18861.1 - 0.031 14.3 0.0 0.046 13.8 0.0 1.4 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 KOS18861.1 - 0.056 13.5 0.0 0.097 12.7 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated DDHD PF02862.17 KOS18862.1 - 2.4e-22 80.2 0.0 7.6e-20 72.0 0.0 2.2 1 1 0 1 1 1 1 DDHD domain Abhydrolase_6 PF12697.7 KOS18862.1 - 0.0097 16.5 0.2 0.017 15.7 0.2 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 KOS18862.1 - 0.058 12.9 0.0 0.26 10.8 0.0 1.9 2 0 0 2 2 2 0 Lipid-droplet associated hydrolase LCAT PF02450.15 KOS18862.1 - 0.25 10.4 0.0 1.5 7.9 0.0 2.1 3 0 0 3 3 3 0 Lecithin:cholesterol acyltransferase APG6 PF04111.12 KOS18863.1 - 1.3e-70 237.0 0.0 2e-70 236.4 0.0 1.3 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 KOS18863.1 - 2e-33 115.7 10.2 2e-33 115.7 10.2 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region DUF4472 PF14739.6 KOS18863.1 - 0.0027 18.4 2.0 0.0027 18.4 2.0 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4472) TMF_TATA_bd PF12325.8 KOS18863.1 - 0.13 12.5 7.0 0.46 10.7 5.8 2.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 KOS18863.1 - 0.45 10.5 8.0 0.15 12.1 4.6 2.0 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 WD40 PF00400.32 KOS18864.1 - 3.7e-14 52.9 12.2 0.056 14.3 0.1 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18864.1 - 1.4e-10 41.4 0.0 8e-05 22.9 0.0 4.7 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS18864.1 - 0.014 15.3 0.1 0.11 12.3 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 KOS18864.1 - 0.61 10.1 4.3 4.3 7.4 0.6 3.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat HIRA_B PF09453.10 KOS18864.1 - 1.2 9.0 5.3 0.26 11.2 1.1 2.2 2 0 0 2 2 2 0 HIRA B motif Sec66 PF09802.9 KOS18865.1 - 0.1 12.1 4.2 0.2 11.2 4.2 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 SLATT_5 PF18160.1 KOS18865.1 - 0.2 11.0 3.1 0.45 9.8 0.4 2.1 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 YqaH PF17448.2 KOS18865.1 - 0.24 11.8 1.3 3.1 8.2 0.4 2.2 1 1 1 2 2 2 0 Uncharacterized YqaH-like Stathmin PF00836.19 KOS18865.1 - 0.33 10.9 11.1 0.028 14.4 6.1 1.7 2 0 0 2 2 2 0 Stathmin family DUF1041 PF06292.17 KOS18865.1 - 0.52 10.7 3.8 0.26 11.7 0.9 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1041) Pkinase PF00069.25 KOS18866.1 - 4.9e-65 219.5 0.0 5.7e-65 219.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18866.1 - 5.2e-19 68.5 0.0 7.3e-19 68.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS18866.1 - 7.3e-10 39.2 0.0 2.7e-06 27.5 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOS18866.1 - 0.0072 15.1 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS18866.1 - 0.0099 15.2 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOS18866.1 - 0.024 14.0 0.2 0.054 12.8 0.2 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOS18866.1 - 0.026 14.1 0.8 0.054 13.1 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase Scm3 PF10384.9 KOS18868.1 - 2.3e-21 75.3 0.1 2.3e-21 75.3 0.1 2.0 2 0 0 2 2 1 1 Centromere protein Scm3 tRNA-synt_1e PF01406.19 KOS18868.1 - 0.0073 15.7 1.4 0.011 15.1 1.4 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Cwf_Cwc_15 PF04889.12 KOS18868.1 - 0.069 12.9 18.3 0.12 12.1 18.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ACR_tran PF00873.19 KOS18868.1 - 0.19 9.4 1.2 0.25 9.0 1.2 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Hid1 PF12722.7 KOS18868.1 - 0.59 8.2 10.8 0.76 7.8 10.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3340 PF11818.8 KOS18868.1 - 0.89 9.7 14.9 1.4 9.0 14.9 1.2 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) XRN_M PF17846.1 KOS18868.1 - 1.9 7.3 8.4 2.4 7.0 8.4 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DDE_Tnp_1_2 PF13586.6 KOS18868.1 - 2.1 8.8 4.3 23 5.5 4.0 2.3 2 0 0 2 2 2 0 Transposase DDE domain Nop14 PF04147.12 KOS18868.1 - 2.3 6.3 18.6 3 5.9 18.6 1.0 1 0 0 1 1 1 0 Nop14-like family DUF5523 PF17661.1 KOS18868.1 - 2.9 7.5 15.1 4.5 6.9 15.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) V_ATPase_I PF01496.19 KOS18868.1 - 3 5.6 8.4 3.8 5.3 8.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPP4R2 PF09184.11 KOS18868.1 - 3.2 7.3 17.6 4.3 6.9 17.6 1.1 1 0 0 1 1 1 0 PPP4R2 Sporozoite_P67 PF05642.11 KOS18868.1 - 4.7 5.2 7.4 6.4 4.7 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 KOS18868.1 - 5 5.3 15.1 7.1 4.8 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOS18868.1 - 5.8 5.6 13.3 7.8 5.1 13.3 1.1 1 0 0 1 1 1 0 Presenilin zf-HYPF PF07503.12 KOS18869.1 - 2.4 8.0 6.7 5.9 6.8 2.2 2.6 2 0 0 2 2 2 0 HypF finger Herpes_DNAp_acc PF04929.12 KOS18870.1 - 0.3 10.0 3.9 0.52 9.2 3.9 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor bZIP_1 PF00170.21 KOS18871.1 - 0.022 14.8 0.5 0.036 14.2 0.5 1.3 1 0 0 1 1 1 0 bZIP transcription factor M11L PF11099.8 KOS18871.1 - 0.023 15.0 1.4 0.029 14.7 1.4 1.1 1 0 0 1 1 1 0 Apoptosis regulator M11L like SecG PF03840.14 KOS18871.1 - 0.038 14.1 0.2 0.048 13.7 0.2 1.3 1 0 0 1 1 1 0 Preprotein translocase SecG subunit FlaC_arch PF05377.11 KOS18871.1 - 0.056 13.8 0.3 0.085 13.3 0.3 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) PspB PF06667.12 KOS18871.1 - 0.26 11.4 1.6 0.31 11.1 0.5 1.7 1 1 0 1 1 1 0 Phage shock protein B Atg14 PF10186.9 KOS18872.1 - 1.1e-70 238.3 0.1 1.4e-70 237.9 0.1 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DnaJ PF00226.31 KOS18873.1 - 6.5e-11 42.2 0.0 1.4e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain RL10P_insert PF17777.1 KOS18875.1 - 5.3e-23 80.8 0.0 1.1e-22 79.7 0.0 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 KOS18875.1 - 3.7e-21 75.1 0.1 1e-20 73.7 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_60s PF00428.19 KOS18875.1 - 2.3e-16 60.2 9.0 3.1e-16 59.8 6.6 2.0 2 0 0 2 2 2 1 60s Acidic ribosomal protein PI3K_1B_p101 PF10486.9 KOS18876.1 - 0.0056 14.5 0.4 0.0083 14.0 0.4 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit WD40 PF00400.32 KOS18876.1 - 0.037 14.9 0.2 24 6.0 0.0 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat Mucin PF01456.17 KOS18876.1 - 0.053 13.5 23.4 0.15 12.1 23.4 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 KOS18876.1 - 0.21 11.6 8.3 0.47 10.4 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ndc1_Nup PF09531.10 KOS18876.1 - 1.9 7.1 3.3 3 6.4 3.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FSA_C PF10479.9 KOS18876.1 - 1.9 6.5 7.6 2.8 6.0 7.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Glycoprotein_G PF00802.19 KOS18876.1 - 2.8 7.2 11.5 4.8 6.5 11.5 1.3 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G CPSF100_C PF13299.6 KOS18876.1 - 5.2 7.2 10.3 14 5.8 10.3 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RIFIN PF02009.16 KOS18876.1 - 8.5 6.2 8.8 14 5.4 8.8 1.2 1 0 0 1 1 1 0 Rifin Glyco_hydro_38N PF01074.22 KOS18877.1 - 6.4e-88 294.9 0.5 9.5e-88 294.3 0.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 KOS18877.1 - 3.4e-51 174.3 0.0 7e-51 173.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 KOS18877.1 - 3.4e-29 100.8 0.8 5.9e-28 96.9 0.1 2.9 3 0 0 3 3 3 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 KOS18877.1 - 2.2e-08 34.1 0.0 6e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Nucleopor_Nup85 PF07575.13 KOS18877.1 - 0.037 12.6 0.0 0.058 12.0 0.0 1.2 1 0 0 1 1 1 0 Nup85 Nucleoporin MutS_V PF00488.21 KOS18878.1 - 2.6e-69 233.0 0.0 4.8e-69 232.2 0.0 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOS18878.1 - 1.1e-43 149.7 4.8 1.9e-43 149.0 4.8 1.4 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOS18878.1 - 4.3e-13 49.5 0.0 6.5e-12 45.7 0.0 2.7 3 0 0 3 3 3 1 MutS domain I MutS_II PF05188.17 KOS18878.1 - 9e-07 29.2 0.1 3.3e-06 27.4 0.0 2.0 2 0 0 2 2 2 1 MutS domain II CCDC92 PF14916.6 KOS18878.1 - 0.0023 17.7 0.1 0.0054 16.5 0.1 1.6 1 0 0 1 1 1 1 Coiled-coil domain of unknown function AAA_29 PF13555.6 KOS18878.1 - 0.079 12.7 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS18878.1 - 0.46 11.0 0.0 0.46 11.0 0.0 2.1 2 1 0 2 2 2 0 AAA domain SEO_N PF14576.6 KOS18879.1 - 0.0048 16.1 0.0 0.0079 15.4 0.0 1.4 1 0 0 1 1 1 1 Sieve element occlusion N-terminus MarR PF01047.22 KOS18879.1 - 0.024 14.6 0.1 1.1 9.3 0.0 2.6 2 0 0 2 2 2 0 MarR family Nop14 PF04147.12 KOS18880.1 - 1.8e-295 982.7 36.7 2.2e-295 982.5 36.7 1.0 1 0 0 1 1 1 1 Nop14-like family DnaJ_C PF01556.18 KOS18881.1 - 8.5e-39 133.0 0.1 1.1e-38 132.6 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOS18881.1 - 9.3e-26 89.8 2.2 1.6e-25 89.0 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOS18881.1 - 2.7e-16 59.7 15.4 5.5e-16 58.7 15.4 1.5 1 0 0 1 1 1 1 DnaJ central domain DUF2614 PF11023.8 KOS18881.1 - 3.9 7.6 7.3 15 5.7 1.8 2.2 1 1 1 2 2 2 0 Zinc-ribbon containing domain HypA PF01155.19 KOS18881.1 - 5.3 7.1 8.7 2.2 8.3 1.3 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc-ribbons_6 PF07191.12 KOS18881.1 - 5.8 7.0 6.6 30 4.7 1.0 2.3 1 1 1 2 2 2 0 zinc-ribbons Anti-TRAP PF15777.5 KOS18881.1 - 6.6 6.8 16.2 4.5 7.3 2.0 2.9 1 1 1 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein CAP_GLY PF01302.25 KOS18882.1 - 3.7e-15 55.7 1.1 6.3e-15 54.9 1.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain CLIP1_ZNF PF16641.5 KOS18882.1 - 3.7e-06 26.7 9.7 0.0014 18.4 1.7 2.5 2 0 0 2 2 2 2 CLIP1 zinc knuckle DUF1640 PF07798.11 KOS18882.1 - 0.019 15.0 1.1 0.019 15.0 1.1 2.6 1 1 1 2 2 1 0 Protein of unknown function (DUF1640) BST2 PF16716.5 KOS18882.1 - 0.21 12.2 21.1 0.94 10.1 1.3 4.2 3 1 1 4 4 4 0 Bone marrow stromal antigen 2 Spc7 PF08317.11 KOS18882.1 - 0.33 9.8 31.8 0.27 10.1 5.0 3.3 2 1 0 3 3 3 0 Spc7 kinetochore protein PEARLI-4 PF05278.12 KOS18882.1 - 0.68 9.5 13.1 1.9 8.0 6.8 2.5 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Phasin_2 PF09361.10 KOS18882.1 - 0.78 10.0 3.8 8.2 6.8 0.1 3.0 3 1 0 3 3 3 0 Phasin protein zf-CCHC_4 PF14392.6 KOS18882.1 - 0.81 9.5 2.1 14 5.5 0.1 2.4 2 0 0 2 2 2 0 Zinc knuckle NPV_P10 PF05531.12 KOS18882.1 - 1.1 9.8 11.1 11 6.5 0.4 4.0 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.15 KOS18882.1 - 1.6 9.1 28.3 2.8 8.3 11.9 2.7 1 1 1 2 2 2 0 Fez1 CENP-F_leu_zip PF10473.9 KOS18882.1 - 1.9 8.5 37.4 0.086 12.9 9.4 3.5 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Glutaredoxin2_C PF04399.13 KOS18882.1 - 1.9 8.3 3.9 6.7 6.6 0.4 2.4 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain TPR_MLP1_2 PF07926.12 KOS18882.1 - 2.7 8.0 32.0 5.5 7.1 4.6 4.1 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3584 PF12128.8 KOS18882.1 - 3.2 5.2 26.2 5.1 4.5 26.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) YabA PF06156.13 KOS18882.1 - 5 7.8 15.3 1.6 9.4 1.6 3.6 3 1 0 3 3 3 0 Initiation control protein YabA DUF4407 PF14362.6 KOS18882.1 - 6.7 6.0 26.0 5 6.4 4.2 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DinB_2 PF12867.7 KOS18882.1 - 7.4 7.1 9.6 63 4.1 6.8 3.1 2 1 0 2 2 2 0 DinB superfamily FlxA PF14282.6 KOS18882.1 - 7.7 6.6 14.2 11 6.1 1.6 3.8 3 0 0 3 3 3 0 FlxA-like protein XPG_I PF00867.18 KOS18883.1 - 1.8e-24 85.9 1.5 5.4e-24 84.4 0.0 2.3 2 0 0 2 2 2 1 XPG I-region GEN1_C PF18380.1 KOS18883.1 - 5e-20 72.3 0.0 5e-20 72.3 0.0 4.0 2 1 0 2 2 2 1 Holliday junction resolvase Gen1 C-terminal domain XPG_N PF00752.17 KOS18883.1 - 1.5e-07 31.9 0.0 5.3e-07 30.1 0.0 2.0 1 0 0 1 1 1 1 XPG N-terminal domain SDA1 PF05285.12 KOS18883.1 - 1.3 8.4 25.3 2.8 7.3 25.3 1.5 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS18883.1 - 6.8 4.8 21.4 11 4.2 21.4 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 KOS18883.1 - 8.2 6.6 22.9 0.031 14.5 5.5 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Actin PF00022.19 KOS18884.1 - 1e-15 57.3 0.0 9.3e-10 37.7 0.0 2.7 3 1 0 3 3 3 2 Actin RITA PF17066.5 KOS18884.1 - 0.6 9.7 5.4 0.18 11.4 1.9 1.8 2 0 0 2 2 2 0 RBPJ-interacting and tubulin associated protein MFS_1 PF07690.16 KOS18885.1 - 2.7e-30 105.5 31.7 2.9e-30 105.4 31.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 KOS18885.1 - 7.4e-05 22.2 5.6 7.4e-05 22.2 5.6 2.0 2 0 0 2 2 2 1 Uncharacterised MFS-type transporter YbfB Methyltransf_23 PF13489.6 KOS18886.1 - 3.6e-15 56.2 0.0 5.5e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS18886.1 - 4.5e-10 40.1 0.0 1.6e-09 38.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS18886.1 - 9e-08 32.0 0.0 3.2e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS18886.1 - 2.4e-07 31.4 0.0 1.6e-06 28.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS18886.1 - 3.3e-06 27.7 0.0 2.6e-05 24.8 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF938 PF06080.12 KOS18886.1 - 0.0011 18.8 0.0 0.003 17.4 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF938) MTS PF05175.14 KOS18886.1 - 0.0014 18.2 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_2 PF00891.18 KOS18886.1 - 0.0038 16.6 0.0 0.005 16.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Ubie_methyltran PF01209.18 KOS18886.1 - 0.0043 16.4 0.0 0.0082 15.5 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 KOS18886.1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.5 2 0 0 2 2 2 0 Putative methyltransferase FtsJ PF01728.19 KOS18886.1 - 0.017 15.2 0.1 0.096 12.8 0.0 2.0 2 1 0 2 2 2 0 FtsJ-like methyltransferase Methyltransf_PK PF05891.12 KOS18886.1 - 0.029 13.9 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_16 PF10294.9 KOS18886.1 - 0.044 13.5 0.0 0.073 12.8 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase CMAS PF02353.20 KOS18886.1 - 0.076 12.3 0.0 0.15 11.3 0.0 1.4 2 0 0 2 2 2 0 Mycolic acid cyclopropane synthetase DUF5576 PF17739.1 KOS18886.1 - 0.15 12.2 0.2 0.26 11.4 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5576) F-box PF00646.33 KOS18887.1 - 2.5e-05 24.0 0.1 6.1e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS18887.1 - 0.0011 18.8 0.3 0.0026 17.6 0.3 1.7 1 0 0 1 1 1 1 F-box-like Pep3_Vps18 PF05131.14 KOS18888.1 - 4.6e-41 140.1 0.0 1e-40 139.0 0.0 1.6 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 KOS18888.1 - 6.9e-10 39.0 2.7 7.7e-07 29.1 0.1 3.1 3 0 0 3 3 3 2 Region in Clathrin and VPS Zn_ribbon_17 PF17120.5 KOS18888.1 - 0.00019 21.0 0.2 0.00037 20.0 0.2 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type DUF2175 PF09943.9 KOS18888.1 - 0.00026 21.2 0.5 0.0031 17.8 0.0 2.8 3 0 0 3 3 3 1 Uncharacterized protein conserved in archaea (DUF2175) zf-C3HC4_2 PF13923.6 KOS18888.1 - 0.00069 19.4 1.0 0.0017 18.2 1.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS18888.1 - 0.0013 18.6 0.6 0.0013 18.6 0.6 1.8 2 0 0 2 2 1 1 zinc-RING finger domain Vps39_2 PF10367.9 KOS18888.1 - 0.0013 19.1 0.1 0.0039 17.6 0.1 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 zf-RING_2 PF13639.6 KOS18888.1 - 0.0073 16.6 0.7 0.022 15.1 0.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 KOS18888.1 - 0.036 14.3 0.2 0.091 13.1 0.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain PKcGMP_CC PF16808.5 KOS18888.1 - 0.14 12.1 0.0 0.45 10.4 0.0 1.9 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-RING_UBOX PF13445.6 KOS18888.1 - 0.18 11.9 0.4 0.5 10.4 0.4 1.7 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_11 PF17123.5 KOS18888.1 - 0.88 9.4 12.6 0.021 14.6 4.6 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-C3H2C3 PF17122.5 KOS18888.1 - 6.5 6.9 6.6 1 9.5 2.4 1.9 2 0 0 2 2 2 0 Zinc-finger Rhodanese PF00581.20 KOS18889.1 - 6.9e-08 33.0 0.0 1.6e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Homeodomain PF00046.29 KOS18889.1 - 3.2e-07 30.1 0.0 1.2e-06 28.3 0.0 1.9 1 0 0 1 1 1 1 Homeodomain PepX_C PF08530.10 KOS18889.1 - 0.094 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Homeobox_KN PF05920.11 KOS18890.1 - 7.2e-20 70.6 1.8 1.2e-19 69.9 1.8 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 KOS18890.1 - 1.1e-09 37.9 2.3 1.6e-09 37.4 2.3 1.2 1 0 0 1 1 1 1 Homeodomain Homez PF11569.8 KOS18890.1 - 0.085 12.3 0.0 3.2 7.3 0.0 2.2 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez MIF PF01187.18 KOS18891.1 - 8.8e-11 42.1 0.0 1.4e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Macrophage migration inhibitory factor (MIF) MgsA_C PF12002.8 KOS18892.1 - 6.2e-62 208.4 0.1 2.1e-61 206.7 0.0 1.9 2 0 0 2 2 2 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 KOS18892.1 - 1.7e-24 86.0 0.4 3.5e-24 84.9 0.4 1.5 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 KOS18892.1 - 1.1e-13 51.8 0.0 2.1e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOS18892.1 - 1.6e-09 37.7 0.0 3.8e-09 36.5 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS18892.1 - 2.9e-07 31.0 4.8 0.0011 19.4 0.0 3.4 2 1 1 3 3 3 1 AAA ATPase domain Sigma54_activat PF00158.26 KOS18892.1 - 1.3e-06 28.2 0.0 8.4e-05 22.3 0.0 2.4 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 KOS18892.1 - 5e-06 26.0 0.0 0.072 12.5 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 KOS18892.1 - 0.00011 22.5 0.1 0.00062 20.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS18892.1 - 0.00016 21.7 0.0 0.0052 16.8 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KOS18892.1 - 0.0005 20.1 0.0 0.0015 18.5 0.0 1.7 1 1 1 2 2 2 1 AAA domain ResIII PF04851.15 KOS18892.1 - 0.0067 16.5 0.1 1.5 8.8 0.0 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 KOS18892.1 - 0.0096 15.8 0.0 0.038 13.9 0.0 2.0 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 KOS18892.1 - 0.013 15.6 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 KOS18892.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 KOS18892.1 - 0.016 15.7 0.0 0.026 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 KOS18892.1 - 0.017 14.3 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain TRAF6_Z2 PF18048.1 KOS18892.1 - 0.021 14.9 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 AAA_24 PF13479.6 KOS18892.1 - 0.024 14.4 0.0 0.04 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KOS18892.1 - 0.027 13.9 0.0 0.096 12.1 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein Cytidylate_kin PF02224.18 KOS18892.1 - 0.064 13.0 0.1 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 Cytidylate kinase DUF927 PF06048.11 KOS18892.1 - 0.093 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF927) CPT PF07931.12 KOS18892.1 - 0.13 12.1 0.1 0.42 10.4 0.0 1.9 1 1 1 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 KOS18892.1 - 0.17 12.2 0.9 2.2 8.6 0.1 2.5 2 1 1 3 3 2 0 AAA domain Menin PF05053.13 KOS18892.1 - 0.46 8.8 5.3 2.7 6.2 0.1 2.2 2 0 0 2 2 2 0 Menin Med13_C PF06333.12 KOS18892.1 - 0.6 9.3 6.8 1.2 8.3 6.8 1.5 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain zf-WRNIP1_ubi PF18279.1 KOS18892.1 - 0.69 10.7 2.0 0.8 10.5 0.2 2.1 2 0 0 2 2 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain AAA_30 PF13604.6 KOS18892.1 - 1.1 9.0 6.9 0.11 12.2 0.4 2.6 2 1 0 2 2 1 0 AAA domain WD40 PF00400.32 KOS18893.1 - 1.3e-40 136.7 32.8 2.4e-08 34.5 0.1 13.4 14 0 0 14 14 14 7 WD domain, G-beta repeat Utp12 PF04003.12 KOS18893.1 - 1.4e-24 86.5 0.0 2.5e-24 85.6 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 KOS18893.1 - 4e-21 75.1 0.0 0.00051 20.3 0.0 9.6 5 2 5 11 11 11 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS18893.1 - 2.6e-07 29.9 2.0 1.5 7.7 0.0 5.8 4 3 2 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOS18893.1 - 7.6e-07 29.2 1.3 0.05 13.5 0.1 5.1 3 2 2 5 5 5 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOS18893.1 - 0.0001 21.7 0.0 0.17 11.2 0.0 3.8 4 0 0 4 4 4 1 WD40-like domain Nbas_N PF15492.6 KOS18893.1 - 0.00072 19.0 0.2 4.6 6.5 0.0 4.1 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 KOS18893.1 - 0.0047 15.6 4.6 1 7.9 0.0 3.9 3 2 1 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.12 KOS18893.1 - 0.015 15.3 0.5 28 4.8 0.1 4.9 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 KOS18893.1 - 0.025 13.1 0.0 4.5 5.7 0.0 3.3 2 1 1 3 3 3 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 KOS18893.1 - 0.13 11.2 0.1 7.4 5.4 0.0 2.8 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Questin_oxidase PF14027.6 KOS18894.1 - 6.5e-63 213.3 0.1 7.4e-63 213.1 0.1 1.0 1 0 0 1 1 1 1 Questin oxidase-like NAP PF00956.18 KOS18895.1 - 2.5e-29 102.3 14.9 2.4e-28 99.1 7.7 2.3 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) BUD22 PF09073.10 KOS18895.1 - 0.04 13.3 13.5 0.053 12.9 13.5 1.2 1 0 0 1 1 1 0 BUD22 MscS_TM PF12794.7 KOS18895.1 - 0.1 11.4 0.3 0.17 10.7 0.3 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 AIM3 PF17096.5 KOS18895.1 - 0.1 13.5 0.2 0.1 13.5 0.2 2.4 3 0 0 3 3 3 0 Altered inheritance of mitochondria protein 3 Drc1-Sld2 PF11719.8 KOS18895.1 - 0.15 11.6 11.5 0.029 13.9 8.2 1.5 2 0 0 2 2 2 0 DNA replication and checkpoint protein DNA_pol_phi PF04931.13 KOS18895.1 - 1 7.3 21.4 1.8 6.6 21.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi Tub_N PF16322.5 KOS18895.1 - 7.5 6.9 12.3 0.14 12.6 2.3 2.1 2 0 0 2 2 2 0 Tubby N-terminal CutC PF03932.14 KOS18896.1 - 1.3e-25 90.1 0.0 4.4e-17 62.2 0.0 2.1 1 1 1 2 2 2 2 CutC family Fungal_trans PF04082.18 KOS18897.1 - 5.5e-13 48.6 0.1 7.7e-13 48.1 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain WD40 PF00400.32 KOS18898.1 - 3.6e-20 71.9 1.6 1.2e-05 25.9 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS18898.1 - 5.1e-05 23.5 0.0 0.58 10.5 0.0 4.6 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KOS18898.1 - 0.0092 15.6 8.6 0.065 12.8 8.3 2.5 1 1 1 2 2 2 2 PQQ-like domain PQQ PF01011.21 KOS18898.1 - 0.012 15.5 1.3 0.7 9.9 0.1 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat Glyco_transf_15 PF01793.16 KOS18899.1 - 2.5e-107 358.9 7.9 3e-107 358.7 7.9 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase GCP_N_terminal PF17681.1 KOS18900.1 - 2.1e-41 142.5 0.0 3e-41 142.0 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOS18900.1 - 7.9e-29 101.1 0.0 1.2e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP5-Mod21 PF14609.6 KOS18900.1 - 6.3e-05 21.5 0.0 0.00043 18.8 0.0 1.9 1 1 0 1 1 1 1 gamma-Tubulin ring complex non-core subunit mod21 BCDHK_Adom3 PF10436.9 KOS18901.1 - 2.1e-45 154.5 0.0 3.4e-45 153.8 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOS18901.1 - 4.6e-08 33.5 0.0 1e-06 29.2 0.0 2.7 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 KOS18901.1 - 0.013 15.3 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Septin PF00735.18 KOS18902.1 - 3.3e-115 384.2 0.4 4.7e-115 383.7 0.4 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOS18902.1 - 2e-07 31.1 0.0 4.2e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS18902.1 - 6.7e-06 26.1 1.1 4.9e-05 23.3 0.0 2.6 3 0 0 3 3 2 1 RsgA GTPase GTP_EFTU PF00009.27 KOS18902.1 - 1e-05 25.1 4.0 0.00011 21.8 0.1 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 KOS18902.1 - 0.0014 18.9 0.6 0.004 17.4 0.0 2.2 2 1 0 2 2 2 1 AAA domain Pox_A32 PF04665.12 KOS18902.1 - 0.0023 17.4 0.1 0.0048 16.4 0.1 1.5 1 0 0 1 1 1 1 Poxvirus A32 protein Roc PF08477.13 KOS18902.1 - 0.0035 17.5 0.1 0.0076 16.5 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AIG1 PF04548.16 KOS18902.1 - 0.0056 16.0 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 AIG1 family IIGP PF05049.13 KOS18902.1 - 0.0073 15.4 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_24 PF13479.6 KOS18902.1 - 0.014 15.2 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS18902.1 - 0.019 15.3 1.1 0.07 13.5 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain KAP_NTPase PF07693.14 KOS18902.1 - 0.02 14.2 0.0 0.028 13.7 0.0 1.6 1 1 0 1 1 1 0 KAP family P-loop domain Ras PF00071.22 KOS18902.1 - 0.028 14.0 0.4 0.089 12.4 0.3 1.9 2 1 0 2 2 2 0 Ras family FOXP-CC PF16159.5 KOS18902.1 - 0.034 14.8 1.2 0.034 14.8 1.2 2.2 2 1 0 2 2 1 0 FOXP coiled-coil domain T2SSE PF00437.20 KOS18902.1 - 0.036 13.1 0.5 0.11 11.6 0.1 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein NACHT PF05729.12 KOS18902.1 - 0.053 13.4 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Val_tRNA-synt_C PF10458.9 KOS18902.1 - 0.058 13.7 0.3 0.058 13.7 0.3 2.6 2 1 0 2 2 2 0 Valyl tRNA synthetase tRNA binding arm ABC_tran PF00005.27 KOS18902.1 - 0.069 13.7 0.2 0.24 11.9 0.0 2.0 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 KOS18902.1 - 0.079 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 KOS18902.1 - 0.09 12.3 0.1 0.23 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOS18902.1 - 0.14 12.5 0.0 0.42 11.0 0.0 1.9 1 0 0 1 1 1 0 RNA helicase PduV-EutP PF10662.9 KOS18902.1 - 0.25 11.1 1.4 4.7 7.0 0.4 2.7 2 1 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 KOS18902.1 - 0.3 11.1 6.0 4.7 7.3 0.0 3.1 2 1 1 3 3 3 0 Dynamin family AAA_11 PF13086.6 KOS18902.1 - 1.1 9.0 6.2 17 5.1 3.2 2.2 2 0 0 2 2 2 0 AAA domain Myc-LZ PF02344.15 KOS18902.1 - 4.9 7.3 7.7 2.2 8.5 1.9 2.5 2 0 0 2 2 2 0 Myc leucine zipper domain C2 PF00168.30 KOS18903.1 - 5.9e-26 90.8 0.0 1.1e-14 54.5 0.0 2.5 2 0 0 2 2 2 2 C2 domain DUF4746 PF15928.5 KOS18903.1 - 0.43 10.0 5.1 0.099 12.0 1.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) FOXP-CC PF16159.5 KOS18904.1 - 0.0018 18.9 1.1 0.55 10.9 0.2 2.3 1 1 1 2 2 2 2 FOXP coiled-coil domain zf-C2H2_4 PF13894.6 KOS18904.1 - 0.15 13.0 0.2 1.3 10.0 0.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 KOS18904.1 - 0.25 11.1 0.5 3.3 7.6 0.4 2.2 2 0 0 2 2 2 0 C2H2-type zinc-finger domain RNase_P_pop3 PF08228.11 KOS18905.1 - 1.2e-08 35.1 0.0 3.4e-06 27.2 0.0 2.1 2 0 0 2 2 2 2 RNase P subunit Pop3 Brix PF04427.18 KOS18907.1 - 1.2e-25 90.7 0.1 1.7e-25 90.2 0.1 1.2 1 0 0 1 1 1 1 Brix domain Sporozoite_P67 PF05642.11 KOS18907.1 - 0.62 8.1 2.9 0.83 7.7 2.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOC3p PF07540.11 KOS18908.1 - 2.1e-30 105.0 1.1 2.1e-29 101.8 0.0 3.1 3 0 0 3 3 3 1 Nucleolar complex-associated protein CBF PF03914.17 KOS18908.1 - 4.2e-25 88.7 0.1 1.4e-24 87.0 0.1 2.0 1 0 0 1 1 1 1 CBF/Mak21 family Mitoc_mL59 PF18126.1 KOS18908.1 - 2.1 8.7 6.5 8.1 6.8 2.3 2.6 2 1 0 2 2 2 0 Mitochondrial ribosomal protein mL59 GDP_Man_Dehyd PF16363.5 KOS18909.1 - 3.7e-69 233.7 0.0 4.3e-69 233.5 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOS18909.1 - 5.2e-58 196.3 0.1 6.5e-58 196.0 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOS18909.1 - 5.3e-21 74.8 0.0 6.8e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOS18909.1 - 1.4e-19 70.4 0.0 2e-18 66.6 0.0 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOS18909.1 - 3.5e-17 62.4 0.0 4.9e-17 62.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 KOS18909.1 - 3.7e-17 62.4 0.3 3e-16 59.4 0.3 2.0 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KOS18909.1 - 6.1e-07 29.5 0.0 1.7e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 KOS18909.1 - 0.045 13.2 0.1 1.5 8.2 0.2 2.4 2 0 0 2 2 2 0 short chain dehydrogenase TPT PF03151.16 KOS18910.1 - 9.7e-05 21.9 16.9 0.021 14.2 1.0 2.3 1 1 1 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 KOS18910.1 - 0.03 14.5 28.8 0.047 13.9 9.1 2.4 2 0 0 2 2 2 0 EamA-like transporter family Phage_holin_2_4 PF16082.5 KOS18910.1 - 0.17 11.6 2.1 2.2 8.1 0.7 2.4 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF2613 PF11021.8 KOS18910.1 - 0.51 10.5 0.1 0.51 10.5 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Pkinase PF00069.25 KOS18911.1 - 2.1e-75 253.5 0.0 2.9e-75 253.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS18911.1 - 4.8e-31 108.0 0.0 1.7e-22 80.0 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOS18911.1 - 5.3e-07 29.2 0.1 0.36 10.1 0.0 3.1 3 0 0 3 3 3 3 Kinase-like Pkinase_fungal PF17667.1 KOS18911.1 - 0.022 13.6 0.0 0.039 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 KOS18911.1 - 0.026 13.9 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS18911.1 - 0.15 12.0 0.0 2.7 7.9 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family tRNA-synt_2b PF00587.25 KOS18912.1 - 4.8e-18 65.8 0.0 8.9e-18 64.9 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 KOS18912.1 - 1.7e-11 44.3 2.0 3.5e-11 43.3 2.0 1.5 1 1 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.6 KOS18912.1 - 0.22 11.5 3.4 1 9.4 3.4 2.0 1 1 0 1 1 1 0 FlxA-like protein DSHCT PF08148.12 KOS18913.1 - 4.3e-50 169.6 0.5 9.8e-50 168.4 0.5 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Ski2_N PF17911.1 KOS18913.1 - 1.7e-37 128.2 0.0 1.2e-36 125.5 0.0 2.1 2 0 0 2 2 2 1 Ski2 N-terminal region rRNA_proc-arch PF13234.6 KOS18913.1 - 4.7e-32 112.0 0.0 8.3e-32 111.2 0.0 1.4 1 0 0 1 1 1 1 rRNA-processing arch domain DEAD PF00270.29 KOS18913.1 - 9.2e-19 67.9 0.0 3.5e-18 66.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS18913.1 - 4.5e-06 27.0 0.0 1.2e-05 25.6 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS18913.1 - 6.5e-06 26.3 0.1 0.00016 21.8 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Transket_pyr PF02779.24 KOS18914.1 - 6.4e-45 153.0 0.0 1.1e-44 152.3 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOS18914.1 - 6.2e-36 123.0 0.0 1.7e-35 121.6 0.0 1.8 1 0 0 1 1 1 1 Transketolase, C-terminal domain FtsA PF14450.6 KOS18914.1 - 0.14 12.6 0.0 0.38 11.2 0.0 1.7 2 0 0 2 2 2 0 Cell division protein FtsA zf-C2H2_jaz PF12171.8 KOS18915.1 - 2.3e-06 27.7 2.6 3.6e-06 27.1 2.6 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS18915.1 - 0.0029 17.9 0.6 0.005 17.2 0.6 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KOS18915.1 - 0.069 13.5 0.9 0.11 12.9 0.9 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 KOS18915.1 - 0.12 12.9 0.9 0.22 12.0 0.9 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS18915.1 - 0.14 13.0 0.4 0.27 12.2 0.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger DUF2057 PF09829.9 KOS18915.1 - 0.22 11.7 2.7 1.3 9.2 0.1 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) DUF1691 PF07950.11 KOS18916.1 - 6.2e-38 129.8 6.9 2.5e-31 108.6 3.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) DUF4405 PF14358.6 KOS18916.1 - 1.7 9.3 5.9 1.9 9.1 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) ABC_tran PF00005.27 KOS18917.1 - 2.6e-31 109.0 0.0 3.7e-31 108.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOS18917.1 - 2.5e-05 23.8 0.1 0.0016 17.9 0.0 2.1 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 KOS18917.1 - 6.2e-05 22.0 0.0 0.00016 20.6 0.0 1.7 2 1 1 3 3 3 1 Predicted ATPase of the ABC class AAA_16 PF13191.6 KOS18917.1 - 0.00042 20.7 0.6 0.00077 19.9 0.5 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOS18917.1 - 0.0005 20.3 0.1 0.0049 17.1 0.1 2.1 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 KOS18917.1 - 0.01 15.1 0.0 0.021 14.1 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 KOS18917.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 KOS18917.1 - 0.017 15.3 0.4 0.088 13.1 0.4 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_5 PF07728.14 KOS18917.1 - 0.023 14.7 0.0 0.089 12.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KOS18917.1 - 0.028 14.1 0.0 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 KOS18917.1 - 0.039 14.2 0.1 0.1 12.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOS18917.1 - 0.042 14.3 0.0 4.6 7.7 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 KOS18917.1 - 0.052 13.3 0.0 0.094 12.4 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_25 PF13481.6 KOS18917.1 - 0.057 13.0 0.1 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 KOS18917.1 - 0.062 13.0 0.0 0.072 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 KOS18917.1 - 0.12 12.1 0.2 0.26 11.1 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 KOS18917.1 - 0.12 12.9 0.0 0.25 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOS18917.1 - 0.13 12.7 0.3 6.3 7.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 KOS18917.1 - 0.14 11.9 0.0 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_membrane PF00664.23 KOS18918.1 - 2.9e-45 155.1 10.3 3.4e-45 154.8 10.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region RAC_head PF16717.5 KOS18920.1 - 6.6e-30 104.0 3.1 6.6e-30 104.0 3.1 3.5 4 1 0 4 4 4 1 Ribosome-associated complex head domain DnaJ PF00226.31 KOS18920.1 - 1e-19 70.4 4.0 4.6e-19 68.3 4.0 2.2 1 0 0 1 1 1 1 DnaJ domain Sterol_MT_C PF08498.10 KOS18921.1 - 1.1e-25 89.7 0.3 1.8e-25 89.0 0.3 1.4 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 KOS18921.1 - 6.8e-20 71.5 0.0 1.3e-19 70.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS18921.1 - 8.4e-18 64.9 0.0 1.7e-17 63.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS18921.1 - 5.2e-17 62.0 0.0 8.2e-17 61.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS18921.1 - 2.3e-13 50.3 0.0 4.3e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS18921.1 - 4.9e-11 42.4 0.0 6.8e-10 38.7 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 KOS18921.1 - 1.3e-10 41.9 0.0 2.3e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOS18921.1 - 4.6e-09 36.0 0.0 7.3e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_15 PF09445.10 KOS18921.1 - 0.0011 18.5 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase TehB PF03848.14 KOS18921.1 - 0.0044 16.4 0.0 0.0079 15.6 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_2 PF00891.18 KOS18921.1 - 0.0055 16.0 0.0 0.0091 15.3 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain PrmA PF06325.13 KOS18921.1 - 0.0057 16.1 0.0 0.013 14.9 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 KOS18921.1 - 0.0057 16.2 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 KOS18921.1 - 0.014 15.4 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOS18921.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MetW PF07021.12 KOS18921.1 - 0.057 13.0 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW RrnaAD PF00398.20 KOS18921.1 - 0.077 12.1 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase RRM_1 PF00076.22 KOS18922.1 - 1.5e-10 40.7 0.0 2.4e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS18922.1 - 2.2e-05 24.2 0.0 3.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 KOS18922.1 - 0.00062 19.7 0.0 0.001 19.0 0.0 1.3 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOS18922.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 RNA binding motif Syntaxin-6_N PF09177.11 KOS18923.1 - 2.4e-25 88.9 0.2 1.3e-24 86.6 0.0 2.0 2 0 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 KOS18923.1 - 3.1e-05 23.9 0.5 8.6e-05 22.4 0.5 1.7 1 0 0 1 1 1 1 SNARE domain DUF3348 PF11828.8 KOS18923.1 - 0.025 14.2 3.7 0.035 13.8 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) Wtap PF17098.5 KOS18923.1 - 0.066 13.2 0.5 6.3 6.7 0.0 2.8 3 0 0 3 3 3 0 WTAP/Mum2p family OmpH PF03938.14 KOS18923.1 - 0.1 12.9 0.7 7.5 6.9 0.7 2.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) ApoLp-III PF07464.11 KOS18923.1 - 0.12 12.5 0.1 18 5.4 0.0 2.9 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 KOS18923.1 - 0.19 11.7 0.9 2.2 8.3 0.2 2.4 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 KOS18923.1 - 0.32 11.0 3.0 8.3 6.5 0.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) KASH_CCD PF14662.6 KOS18923.1 - 0.35 10.7 2.4 0.74 9.6 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Filament PF00038.21 KOS18923.1 - 0.36 10.4 4.9 0.69 9.4 1.1 2.3 2 1 1 3 3 3 0 Intermediate filament protein Spc7 PF08317.11 KOS18923.1 - 0.37 9.6 1.6 7 5.4 0.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Myosin_tail_1 PF01576.19 KOS18923.1 - 0.58 7.9 4.2 4.9 4.8 1.3 2.0 2 0 0 2 2 2 0 Myosin tail ATG16 PF08614.11 KOS18923.1 - 2.3 8.4 9.7 2.3 8.4 2.0 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) WXG100 PF06013.12 KOS18923.1 - 3.7 7.8 8.2 19 5.5 1.8 3.3 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Methyltransf_32 PF13679.6 KOS18924.1 - 2.6e-21 76.3 0.0 4.4e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ACT_7 PF13840.6 KOS18925.1 - 5e-21 74.3 0.1 1.2e-14 53.8 0.0 2.4 2 0 0 2 2 2 2 ACT domain Zip PF02535.22 KOS18925.1 - 0.0052 16.0 0.7 0.0061 15.8 0.7 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter SelP_N PF04592.14 KOS18925.1 - 0.21 11.0 25.3 0.35 10.2 25.3 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Mito_fiss_reg PF05308.11 KOS18925.1 - 0.97 9.5 3.5 1.6 8.8 3.5 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator SPX PF03105.19 KOS18925.1 - 4 7.2 8.9 5.2 6.9 8.9 1.1 1 0 0 1 1 1 0 SPX domain UPF0029 PF01205.19 KOS18926.1 - 5.5e-30 103.8 0.0 8.9e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 KOS18926.1 - 1.3e-05 25.4 0.0 2e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 RWD domain ATP-synt_ab PF00006.25 KOS18927.1 - 4.4e-108 359.8 0.0 5.8e-108 359.4 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 KOS18927.1 - 8e-46 154.8 0.0 1.8e-45 153.7 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 KOS18927.1 - 1.7e-15 57.3 2.5 1.7e-14 54.1 3.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Metallophos PF00149.28 KOS18929.1 - 7.4e-14 52.7 0.2 1.1e-13 52.1 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase C-C_Bond_Lyase PF15617.6 KOS18929.1 - 0.016 14.4 0.0 0.024 13.8 0.0 1.2 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold Pet127 PF08634.10 KOS18930.1 - 8.8e-118 392.7 1.3 1.4e-117 392.0 1.3 1.4 1 0 0 1 1 1 1 Mitochondrial protein Pet127 Shadoo PF14999.6 KOS18930.1 - 1.1 9.3 6.1 2.8 8.1 6.1 1.6 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective RNB PF00773.19 KOS18931.1 - 5.2e-70 236.4 0.0 8.8e-70 235.6 0.0 1.4 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 KOS18931.1 - 1.8e-25 88.7 0.0 4.2e-25 87.6 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 KOS18931.1 - 6.3e-25 87.3 0.5 1.8e-24 85.9 0.0 2.1 2 0 0 2 2 2 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 KOS18931.1 - 0.00016 21.7 0.0 0.09 13.0 0.0 2.8 2 0 0 2 2 2 2 Cold shock domain Rrp44_CSD1 PF17216.3 KOS18931.1 - 0.28 10.9 0.0 0.28 10.9 0.0 1.8 2 0 0 2 2 2 0 Rrp44-like cold shock domain GLE1 PF07817.13 KOS18932.1 - 9.4e-64 215.0 0.0 1.3e-63 214.6 0.0 1.2 1 0 0 1 1 1 1 GLE1-like protein DUF4407 PF14362.6 KOS18932.1 - 2.4 7.4 7.1 0.9 8.8 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) ATP-synt_ab PF00006.25 KOS18933.1 - 2.5e-62 210.3 0.0 3.6e-62 209.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOS18933.1 - 3.1e-24 85.3 0.5 2.3e-23 82.5 0.3 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA PF00004.29 KOS18933.1 - 0.017 15.6 0.1 0.43 11.0 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 KOS18933.1 - 0.021 14.0 0.2 0.092 11.9 0.1 1.9 2 0 0 2 2 2 0 NB-ARC domain RsgA_GTPase PF03193.16 KOS18933.1 - 0.023 14.6 1.7 0.035 14.0 0.1 2.0 3 0 0 3 3 3 0 RsgA GTPase ATPase_2 PF01637.18 KOS18933.1 - 0.029 14.3 0.0 0.069 13.1 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea ATPase PF06745.13 KOS18933.1 - 0.03 13.7 0.2 0.048 13.0 0.2 1.3 1 0 0 1 1 1 0 KaiC T3SS_ATPase_C PF18269.1 KOS18933.1 - 0.045 13.6 0.5 0.25 11.2 0.5 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain NACHT PF05729.12 KOS18933.1 - 0.049 13.5 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 KOS18933.1 - 0.079 13.4 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 KOS18933.1 - 0.088 13.2 0.1 0.34 11.3 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 KOS18933.1 - 0.088 13.1 0.6 0.47 10.8 0.2 2.1 2 0 0 2 2 2 0 AAA domain Aldedh PF00171.22 KOS18934.1 - 5.3e-162 539.5 0.0 6e-162 539.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FAM176 PF14851.6 KOS18935.1 - 0.0099 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 FAM176 family RRF PF01765.19 KOS18937.1 - 3.4e-31 108.4 0.5 4.2e-31 108.1 0.5 1.1 1 0 0 1 1 1 1 Ribosome recycling factor DUF1870 PF08965.10 KOS18937.1 - 0.078 13.0 0.6 0.14 12.2 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) SUR7 PF06687.12 KOS18938.1 - 4e-30 105.0 5.5 5.2e-30 104.7 5.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family Metallophos PF00149.28 KOS18939.1 - 1.9e-34 120.0 0.1 3.1e-34 119.3 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOS18939.1 - 1.9e-15 57.0 0.0 3.5e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain ADH_N PF08240.12 KOS18940.1 - 6.7e-28 96.8 3.6 1.4e-27 95.7 3.6 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS18940.1 - 1.1e-13 51.2 0.1 1.8e-13 50.6 0.1 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS18940.1 - 0.0001 21.9 1.1 0.067 12.7 0.1 3.2 3 0 0 3 3 3 2 Glucose dehydrogenase C-terminus UDPG_MGDP_dh_N PF03721.14 KOS18940.1 - 0.065 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain WD40 PF00400.32 KOS18941.1 - 1.7e-11 44.4 9.5 0.012 16.4 0.0 8.1 8 0 0 8 8 8 3 WD domain, G-beta repeat WD40_like PF17005.5 KOS18941.1 - 0.021 14.1 0.0 0.067 12.5 0.0 1.8 2 0 0 2 2 2 0 WD40-like domain HATPase_c PF02518.26 KOS18942.1 - 9.3e-22 77.7 0.1 1.9e-21 76.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS18942.1 - 1.2e-20 73.8 0.0 2.4e-20 72.8 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain PAS_4 PF08448.10 KOS18942.1 - 2.6e-13 50.2 0.0 9.3e-06 25.9 0.0 2.9 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KOS18942.1 - 3.4e-08 33.5 0.0 1e-07 32.0 0.0 1.9 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 KOS18942.1 - 5.2e-08 33.1 0.0 1.4e-05 25.3 0.0 2.7 2 0 0 2 2 2 1 PAS domain HisKA PF00512.25 KOS18942.1 - 6.6e-07 29.3 0.7 1.8e-06 27.8 0.1 2.2 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 KOS18942.1 - 0.00077 19.7 0.3 0.0075 16.5 0.0 2.7 2 0 0 2 2 2 1 PAS fold PAS_8 PF13188.7 KOS18942.1 - 0.0053 16.7 0.0 0.03 14.4 0.0 2.3 2 0 0 2 2 2 1 PAS domain GAF_2 PF13185.6 KOS18942.1 - 0.0079 16.5 0.0 1 9.7 0.0 2.7 2 0 0 2 2 2 1 GAF domain GAF_3 PF13492.6 KOS18942.1 - 0.096 13.0 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 GAF domain PH_6 PF15406.6 KOS18943.1 - 6.4e-33 113.4 0.3 6.4e-33 113.4 0.3 2.8 3 0 0 3 3 3 1 Pleckstrin homology domain PH PF00169.29 KOS18943.1 - 0.025 15.1 0.0 0.062 13.8 0.0 1.7 1 0 0 1 1 1 0 PH domain STT3 PF02516.14 KOS18944.1 - 1.6e-142 475.9 31.0 1.7e-137 459.3 29.1 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit CPSase_L_D2 PF02786.17 KOS18945.1 - 6.6e-81 270.8 0.3 1e-80 270.2 0.3 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 KOS18945.1 - 1.8e-67 227.0 0.0 2.9e-67 226.3 0.0 1.4 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 KOS18945.1 - 5.5e-39 133.1 0.0 1.2e-38 132.0 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOS18945.1 - 4e-31 107.3 0.0 1.7e-30 105.3 0.0 2.1 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 KOS18945.1 - 1.8e-26 93.3 0.0 3.5e-26 92.3 0.0 1.4 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 KOS18945.1 - 7.8e-19 67.3 1.3 2e-18 66.0 1.3 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOS18945.1 - 3.6e-11 42.7 0.3 5.4e-06 26.1 0.0 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 KOS18945.1 - 1.5e-08 34.5 0.0 3e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 KOS18945.1 - 9.5e-07 28.5 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KOS18945.1 - 1.1e-05 25.1 0.0 3.4e-05 23.5 0.0 1.7 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KOS18945.1 - 9.4e-05 22.5 0.0 0.00022 21.3 0.0 1.7 1 0 0 1 1 1 1 ATP-grasp domain HlyD_D23 PF16576.5 KOS18945.1 - 0.00042 19.6 0.1 0.15 11.2 0.0 2.5 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 KOS18945.1 - 0.00067 20.3 0.1 3.2 8.5 0.0 3.4 4 0 0 4 4 2 2 HlyD family secretion protein ATPgrasp_ST PF14397.6 KOS18945.1 - 0.01 15.1 0.0 0.028 13.7 0.0 1.7 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp DUF2118 PF09891.9 KOS18945.1 - 0.016 15.1 0.1 0.055 13.4 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) RnfC_N PF13375.6 KOS18945.1 - 0.022 14.7 0.3 0.062 13.3 0.3 1.7 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain NQRA PF05896.11 KOS18945.1 - 0.038 13.4 0.1 0.066 12.6 0.1 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) ATP-grasp_4 PF13535.6 KOS18945.1 - 0.11 12.1 0.0 0.27 10.8 0.0 1.7 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_YheCD PF14398.6 KOS18945.1 - 0.12 11.6 0.0 3.6 6.8 0.0 2.2 2 0 0 2 2 2 0 YheC/D like ATP-grasp MPC PF03650.13 KOS18946.1 - 4.2e-36 123.4 0.0 4.9e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers Corona_S2 PF01601.16 KOS18947.1 - 0.0003 19.4 12.7 0.00039 19.1 12.7 1.1 1 0 0 1 1 1 1 Coronavirus S2 glycoprotein RCR PF12273.8 KOS18948.1 - 7.8e-12 45.9 11.9 3.3e-11 43.9 11.9 1.8 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF998 PF06197.13 KOS18948.1 - 0.0027 17.4 0.4 0.0037 16.9 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF998) DUF4131 PF13567.6 KOS18948.1 - 0.0053 16.4 0.2 0.0077 15.9 0.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) GRA6 PF05084.13 KOS18948.1 - 0.034 14.1 0.3 0.05 13.6 0.3 1.2 1 0 0 1 1 1 0 Granule antigen protein (GRA6) DUF2207 PF09972.9 KOS18948.1 - 0.05 12.4 0.1 0.061 12.1 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) MHYT PF03707.16 KOS18948.1 - 0.06 13.5 1.1 0.1 12.8 1.1 1.3 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat SARAF PF06682.12 KOS18948.1 - 0.13 11.9 1.7 0.19 11.3 1.7 1.4 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4381 PF14316.6 KOS18948.1 - 1.1 9.5 5.8 2.2 8.5 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Gram_pos_anchor PF00746.21 KOS18948.1 - 1.8 8.6 3.8 3.8 7.5 3.8 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif VPDSG-CTERM PF18205.1 KOS18948.1 - 3.5 7.5 8.6 10 6.0 8.6 1.8 1 1 0 1 1 1 0 VPDSG-CTERM motif APC_rep PF18797.1 KOS18950.1 - 0.13 13.2 0.0 0.28 12.1 0.0 1.6 1 0 0 1 1 1 0 Adenomatous polyposis coli (APC) repeat Fungal_trans_2 PF11951.8 KOS18951.1 - 1.1e-79 268.0 0.4 1.3e-79 267.8 0.4 1.0 1 0 0 1 1 1 1 Fungal specific transcription factor domain SAM_2 PF07647.17 KOS18952.1 - 9.2e-06 25.7 0.0 2e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 KOS18952.1 - 1.1e-05 25.9 0.1 5.4e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 PH domain Sod_Fe_C PF02777.18 KOS18953.1 - 5e-12 45.9 0.0 9.3e-10 38.6 0.0 2.3 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KOS18953.1 - 0.027 14.9 0.1 0.042 14.3 0.1 1.3 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain STIMATE PF12400.8 KOS18954.1 - 8.1e-28 97.5 3.2 8.1e-28 97.5 3.2 2.3 2 1 1 3 3 3 1 STIMATE family Spt5_N PF11942.8 KOS18954.1 - 5.6 8.0 9.7 5.2 8.1 5.8 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Cofilin_ADF PF00241.20 KOS18955.1 - 2e-27 95.4 0.0 4.5e-15 55.5 0.0 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein HILPDA PF15220.6 KOS18955.1 - 0.18 12.0 0.1 0.42 10.8 0.1 1.6 1 0 0 1 1 1 0 Hypoxia-inducible lipid droplet-associated Vps54 PF07928.12 KOS18957.1 - 2.3e-51 173.7 0.5 6e-51 172.4 0.1 2.0 2 0 0 2 2 2 1 Vps54-like protein Vps54_N PF10475.9 KOS18957.1 - 8.7e-06 25.2 1.8 1.7e-05 24.2 1.8 1.4 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex DUF2451 PF10474.9 KOS18957.1 - 0.0037 17.1 0.0 0.011 15.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) COG2 PF06148.11 KOS18957.1 - 0.34 11.0 2.0 1.3 9.2 2.0 2.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 MFAP1 PF06991.11 KOS18958.1 - 8.4e-69 231.7 21.8 8.4e-69 231.7 21.8 2.9 1 1 2 3 3 3 1 Microfibril-associated/Pre-mRNA processing Y2_Tnp PF04986.13 KOS18958.1 - 0.22 11.5 1.0 0.42 10.6 1.0 1.5 1 0 0 1 1 1 0 Putative transposase Pol_alpha_B_N PF08418.10 KOS18959.1 - 4.6e-71 239.7 0.0 6.9e-71 239.1 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 KOS18959.1 - 3.3e-36 124.6 0.0 4.6e-36 124.2 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B SmaI PF17411.2 KOS18959.1 - 0.018 14.2 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease PH PF00169.29 KOS18960.1 - 0.00029 21.3 0.1 0.001 19.5 0.1 1.9 2 0 0 2 2 2 1 PH domain RmlD_sub_bind PF04321.17 KOS18961.1 - 4.9e-54 183.4 0.0 5.7e-54 183.1 0.0 1.0 1 0 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 KOS18961.1 - 2.1e-19 69.9 0.0 2.8e-19 69.5 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS18961.1 - 1.3e-09 38.0 0.0 1.8e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOS18961.1 - 3.4e-08 33.0 0.0 9.7e-08 31.5 0.0 1.8 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 KOS18961.1 - 1e-05 24.9 0.0 0.00015 21.0 0.0 2.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 KOS18961.1 - 0.00047 19.3 0.0 0.00062 18.9 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ANAPC8 PF04049.13 KOS18962.1 - 9.3e-56 187.8 2.0 1.1e-55 187.5 0.6 1.9 2 0 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_8 PF13181.6 KOS18962.1 - 6.3e-21 72.8 7.4 7.3e-05 22.7 0.0 7.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOS18962.1 - 4e-20 70.7 4.5 9.2e-05 22.1 0.0 7.8 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS18962.1 - 4.3e-13 48.3 15.9 0.032 14.4 0.0 9.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOS18962.1 - 2.3e-08 33.6 0.2 1.2e-06 28.1 0.1 3.1 3 0 0 3 3 3 1 TPR repeat TPR_14 PF13428.6 KOS18962.1 - 1.1e-07 32.0 20.4 0.0061 17.3 0.1 9.3 9 2 2 11 11 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS18962.1 - 5.8e-07 30.1 14.2 2.6e-05 24.8 0.1 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS18962.1 - 6.9e-07 29.5 15.4 0.27 11.6 0.1 7.3 5 1 1 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS18962.1 - 1e-05 25.6 8.2 0.042 14.1 0.8 5.5 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 KOS18962.1 - 0.00069 19.7 0.9 0.071 13.2 0.1 3.1 1 1 1 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_17 PF13431.6 KOS18962.1 - 0.0019 18.4 0.1 6.9 7.3 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS18962.1 - 0.0035 17.3 9.4 0.048 13.7 0.0 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOS18962.1 - 0.017 15.6 12.7 6.4 7.4 0.0 6.7 7 1 1 8 8 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOS18962.1 - 0.048 13.6 2.3 49 4.0 0.2 4.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Say1_Mug180 PF10340.9 KOS18962.1 - 0.081 11.8 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase TPR_9 PF13371.6 KOS18962.1 - 0.093 12.9 11.1 2.4 8.4 0.3 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOS18962.1 - 0.55 11.0 21.5 34 5.4 0.0 8.9 11 0 0 11 11 11 0 Tetratricopeptide repeat Dicty_REP PF05086.12 KOS18962.1 - 1.1 7.1 3.7 1.6 6.6 3.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 KOS18962.1 - 2.5 8.1 11.7 5.4 7.0 11.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) polyprenyl_synt PF00348.17 KOS18963.1 - 1e-88 296.7 0.0 1.3e-88 296.4 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase YkyB PF14177.6 KOS18963.1 - 0.067 13.5 0.0 0.15 12.4 0.0 1.6 1 1 0 1 1 1 0 YkyB-like protein Methyltransf_15 PF09445.10 KOS18966.1 - 3.6e-37 127.5 0.0 6.9e-36 123.3 0.0 2.0 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_5 PF01795.19 KOS18966.1 - 0.08 12.4 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 MraW methylase family GRASP55_65 PF04495.14 KOS18967.1 - 7.3e-45 152.7 0.0 4.7e-44 150.0 0.0 1.9 1 1 1 2 2 2 2 GRASP55/65 PDZ-like domain PDZ_6 PF17820.1 KOS18967.1 - 0.00063 19.5 1.7 0.78 9.6 0.0 2.8 3 0 0 3 3 3 2 PDZ domain Trs65 PF12735.7 KOS18968.1 - 4.4e-98 328.6 0.0 6e-98 328.1 0.0 1.1 1 0 0 1 1 1 1 TRAPP trafficking subunit Trs65 Synaphin PF05835.12 KOS18968.1 - 0.19 12.0 4.8 0.32 11.3 4.8 1.2 1 0 0 1 1 1 0 Synaphin protein FF PF01846.19 KOS18969.1 - 1.6e-48 162.6 12.5 5.9e-14 52.0 0.0 5.7 5 0 0 5 5 5 5 FF domain WW PF00397.26 KOS18969.1 - 3.9e-18 65.2 17.0 7.2e-10 38.8 3.4 2.6 2 0 0 2 2 2 2 WW domain Lipin_mid PF16876.5 KOS18969.1 - 0.024 14.8 0.3 1.6 8.9 0.0 2.9 1 1 1 2 2 2 0 Lipin/Ned1/Smp2 multi-domain protein middle domain Glyco_hyd_101C PF17451.2 KOS18969.1 - 2.3 8.5 7.3 1.9 8.8 1.6 2.6 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Homeodomain PF00046.29 KOS18970.1 - 6.1e-15 54.8 3.1 1.2e-14 53.8 3.1 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOS18970.1 - 0.0033 17.3 1.4 0.0057 16.5 0.6 1.8 2 0 0 2 2 2 1 Homeobox KN domain AdoMetDC_leader PF08132.11 KOS18970.1 - 0.015 15.2 0.4 0.032 14.2 0.4 1.6 1 0 0 1 1 1 0 S-adenosyl-l-methionine decarboxylase leader peptide SLD3 PF08639.10 KOS18971.1 - 6.5e-127 424.5 1.6 6.5e-127 424.5 1.6 1.6 2 0 0 2 2 2 1 DNA replication regulator SLD3 Peptidase_C15 PF01470.17 KOS18972.1 - 1.6e-06 28.4 0.0 7.8e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Pyroglutamyl peptidase HAD_2 PF13419.6 KOS18973.1 - 4e-16 59.6 0.0 1.3e-14 54.7 0.0 2.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS18973.1 - 5.6e-11 43.1 0.0 1.5e-06 28.6 0.0 2.2 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS18973.1 - 1.6e-06 28.1 0.1 2.6e-06 27.4 0.1 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 KOS18973.1 - 0.003 18.0 0.0 1.3 9.3 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase GHL6 PF14871.6 KOS18973.1 - 0.024 14.8 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 DAD PF02109.16 KOS18974.1 - 3.1e-48 162.6 2.2 3.7e-48 162.3 2.2 1.1 1 0 0 1 1 1 1 DAD family Tmemb_14 PF03647.13 KOS18975.1 - 6.1e-23 81.4 6.8 7.3e-23 81.1 6.8 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C CytB6-F_Fe-S PF08802.10 KOS18975.1 - 1.6 8.8 8.1 0.98 9.5 0.7 3.0 3 0 0 3 3 3 0 Cytochrome B6-F complex Fe-S subunit HLH PF00010.26 KOS18976.1 - 2.2e-12 46.8 0.3 5e-12 45.6 0.3 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain GIT1_C PF12205.8 KOS18976.1 - 0.028 14.5 1.6 0.25 11.5 1.6 2.1 1 1 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term DivIC PF04977.15 KOS18976.1 - 0.039 13.7 0.8 0.078 12.8 0.8 1.5 1 0 0 1 1 1 0 Septum formation initiator Pox_A30L_A26L PF06086.12 KOS18976.1 - 0.13 11.9 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Orthopoxvirus A26L/A30L protein Rootletin PF15035.6 KOS18976.1 - 0.15 12.1 5.3 0.26 11.3 5.3 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion BRO1 PF03097.18 KOS18977.1 - 2.5e-06 26.6 0.0 3.7e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 BRO1-like domain Alg6_Alg8 PF03155.15 KOS18978.1 - 5.5e-128 428.0 21.5 1.6e-81 274.8 10.4 2.2 2 0 0 2 2 2 2 ALG6, ALG8 glycosyltransferase family Ribosomal_60s PF00428.19 KOS18979.1 - 2.2e-25 89.1 16.8 2.6e-25 88.8 16.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF3824 PF12868.7 KOS18979.1 - 5.7 7.6 6.5 7.8 7.1 6.5 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) DUF1749 PF08538.10 KOS18980.1 - 1.8e-78 263.7 0.0 2.1e-78 263.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) Abhydrolase_6 PF12697.7 KOS18980.1 - 8e-08 33.1 0.0 1.8e-07 32.0 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS18980.1 - 1.7e-07 31.2 0.1 6e-06 26.1 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS18980.1 - 6.2e-07 28.9 0.0 1.1e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOS18980.1 - 0.013 14.9 0.0 0.72 9.3 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family Ser_hydrolase PF06821.13 KOS18980.1 - 0.016 15.1 0.0 0.095 12.6 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_9 PF10081.9 KOS18980.1 - 0.12 11.5 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family ABC_membrane PF00664.23 KOS18981.1 - 1.9e-88 296.7 29.0 3.4e-47 161.4 8.7 2.5 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOS18981.1 - 3.2e-50 170.2 0.0 4.6e-30 104.9 0.1 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOS18981.1 - 1.4e-09 37.7 5.5 0.0033 16.9 0.2 4.2 2 2 0 4 4 4 3 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOS18981.1 - 1.2e-05 25.4 0.3 0.22 11.6 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS18981.1 - 0.0012 18.7 0.1 0.63 9.9 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 KOS18981.1 - 0.0049 16.6 0.3 2.1 8.2 0.0 2.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF87 PF01935.17 KOS18981.1 - 0.0066 16.6 0.3 0.77 9.8 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain Dynamin_N PF00350.23 KOS18981.1 - 0.0066 16.5 2.0 0.27 11.3 0.2 2.5 2 0 0 2 2 2 1 Dynamin family AAA_21 PF13304.6 KOS18981.1 - 0.034 14.0 0.1 6.6 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOS18981.1 - 0.064 12.9 0.0 11 5.6 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 KOS18981.1 - 0.071 12.9 1.7 7.3 6.3 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 KOS18981.1 - 0.071 13.5 1.5 0.77 10.1 0.3 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 KOS18981.1 - 0.092 13.2 0.1 13 6.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOS18981.1 - 0.14 12.5 2.3 35 4.7 0.0 3.4 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOS18981.1 - 0.18 12.2 0.0 7.9 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase DUF2841 PF11001.8 KOS18982.1 - 3.4e-43 146.6 2.5 4.9e-43 146.1 2.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2841) PQ-loop PF04193.14 KOS18983.1 - 5e-37 125.5 11.9 1.2e-18 66.7 0.6 2.7 2 0 0 2 2 2 2 PQ loop repeat ER_lumen_recept PF00810.18 KOS18983.1 - 0.02 15.7 0.1 4.7 8.0 0.0 2.6 2 0 0 2 2 2 0 ER lumen protein retaining receptor DUF4381 PF14316.6 KOS18983.1 - 0.21 11.8 2.1 0.82 9.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) NUDIX PF00293.28 KOS18984.1 - 1.3e-15 57.6 0.2 2.3e-15 56.8 0.2 1.4 1 0 0 1 1 1 1 NUDIX domain NUDIX-like PF09296.11 KOS18984.1 - 7.8e-10 39.3 0.2 2.7e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 NADH pyrophosphatase-like rudimentary NUDIX domain zf-NADH-PPase PF09297.11 KOS18984.1 - 8.2e-08 31.8 0.5 1.6e-07 30.9 0.5 1.4 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain Pex2_Pex12 PF04757.14 KOS18985.1 - 1.1e-35 123.2 2.7 1.6e-35 122.7 2.7 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_4 PF15227.6 KOS18985.1 - 0.00026 21.1 4.0 0.00053 20.1 4.0 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KOS18985.1 - 0.017 15.1 1.0 0.056 13.5 1.0 1.9 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 KOS18985.1 - 0.078 12.9 1.7 0.19 11.7 1.7 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cytochrom_B558a PF05038.13 KOS18986.1 - 0.017 14.7 0.1 0.057 13.0 0.1 1.9 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit TMEM171 PF15471.6 KOS18987.1 - 0.67 8.9 2.1 0.74 8.7 2.1 1.0 1 0 0 1 1 1 0 Transmembrane protein family 171 Zn_clus PF00172.18 KOS18988.1 - 3.1e-05 24.0 10.4 6.6e-05 22.9 10.4 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOS18988.1 - 0.0006 18.9 0.1 0.0013 17.8 0.1 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain HMG_box PF00505.19 KOS18989.1 - 3.8e-06 27.2 0.2 3.8e-06 27.2 0.2 2.7 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOS18989.1 - 0.0021 18.6 0.7 0.016 15.8 0.1 2.5 2 0 0 2 2 2 1 HMG-box domain CDC45 PF02724.14 KOS18989.1 - 4.3 5.5 10.1 6 5.0 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Het-C PF07217.11 KOS18990.1 - 2.1e-228 759.4 0.0 2.6e-228 759.1 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Tti2 PF10521.9 KOS18990.1 - 0.21 11.1 0.5 2.5 7.6 0.1 2.2 2 0 0 2 2 2 0 Tti2 family zf-RING_2 PF13639.6 KOS18991.1 - 2.8e-08 34.0 11.6 4.6e-08 33.3 11.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOS18991.1 - 4.8e-05 23.1 11.0 8.2e-05 22.4 11.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS18991.1 - 0.00023 20.8 11.2 0.00023 20.8 11.2 2.1 1 1 1 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 KOS18991.1 - 0.0013 19.0 9.1 0.0033 17.7 9.1 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOS18991.1 - 0.0031 17.3 11.4 0.0056 16.5 11.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOS18991.1 - 0.019 15.0 5.9 0.039 14.0 5.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOS18991.1 - 0.064 12.9 9.0 0.13 11.9 9.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type LapA_dom PF06305.11 KOS18991.1 - 0.066 13.0 1.9 0.073 12.9 0.1 1.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF3955 PF13127.6 KOS18991.1 - 0.15 11.9 3.0 0.27 11.1 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3955) zf-RING_5 PF14634.6 KOS18991.1 - 0.18 11.8 11.1 0.3 11.1 11.1 1.3 1 0 0 1 1 1 0 zinc-RING finger domain HemY_N PF07219.13 KOS18991.1 - 0.25 11.6 1.2 0.63 10.3 1.2 1.7 1 0 0 1 1 1 0 HemY protein N-terminus YdjO PF14169.6 KOS18991.1 - 2.7 7.8 7.1 14 5.5 1.9 3.1 3 0 0 3 3 3 0 Cold-inducible protein YdjO Ada3 PF10198.9 KOS18993.1 - 2e-56 189.8 0.2 4.8e-56 188.5 0.2 1.7 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 Amidohydro_1 PF01979.20 KOS18994.1 - 1e-73 248.7 0.2 1.7e-73 247.9 0.2 1.3 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 KOS18994.1 - 5.2e-55 184.9 2.3 5.2e-55 184.9 2.3 1.9 2 0 0 2 2 2 1 Urease alpha-subunit, N-terminal domain Urease_beta PF00699.20 KOS18994.1 - 9e-43 144.3 0.1 2.2e-42 143.1 0.1 1.7 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 KOS18994.1 - 1.2e-38 131.4 0.2 2.8e-38 130.2 0.1 1.8 2 0 0 2 2 2 1 Urease, gamma subunit Amidohydro_3 PF07969.11 KOS18994.1 - 2.6e-09 37.1 0.1 5e-06 26.2 0.0 2.3 2 0 0 2 2 2 2 Amidohydrolase family ATP_transf PF09830.9 KOS18995.1 - 5.5e-20 71.3 0.0 8.5e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 ATP adenylyltransferase Scs3p PF10261.9 KOS18996.1 - 4.3e-74 249.1 0.7 6e-74 248.7 0.7 1.2 1 0 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM NDUF_B12 PF08122.12 KOS18996.1 - 1.4 9.0 4.7 0.44 10.6 0.6 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family SSP160 PF06933.11 KOS18996.1 - 5 5.2 13.8 7.3 4.7 13.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Man-6-P_recep PF02157.15 KOS18997.1 - 1.2e-12 47.5 0.0 2.1e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Mannose-6-phosphate receptor ATG27 PF09451.10 KOS18997.1 - 4.3e-11 43.2 0.0 3.8e-10 40.1 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein 27 CIMR PF00878.18 KOS18997.1 - 6.8e-09 35.9 0.0 3e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat Tic110 PF16940.5 KOS18997.1 - 0.57 8.6 1.7 0.78 8.2 1.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter Med3 PF11593.8 KOS18997.1 - 7.5 5.6 9.7 0.42 9.8 0.8 1.9 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal MBOAT_2 PF13813.6 KOS18999.1 - 1e-21 77.0 7.0 3.3e-21 75.4 7.0 1.9 1 0 0 1 1 1 1 Membrane bound O-acyl transferase family PAT1 PF09770.9 KOS19000.1 - 4.9 5.3 10.7 6.3 4.9 10.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 PseudoU_synth_1 PF01416.20 KOS19001.1 - 9.8e-11 42.1 0.0 2.8e-09 37.4 0.0 2.7 2 0 0 2 2 2 1 tRNA pseudouridine synthase DNA_pol_phi PF04931.13 KOS19001.1 - 0.014 13.5 1.5 0.02 13.0 1.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2344 PF10105.9 KOS19001.1 - 0.034 14.0 0.1 0.92 9.3 0.0 2.6 2 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2344) Med22 PF06179.12 KOS19002.1 - 1.4e-19 70.2 0.0 1.6e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex UPF0052 PF01933.18 KOS19003.1 - 7.4e-54 183.0 0.0 1e-53 182.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 Glyco_hydro_3_C PF01915.22 KOS19004.1 - 2.1e-42 145.4 0.0 5e-42 144.2 0.0 1.6 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS19004.1 - 7e-36 124.2 0.0 1.2e-35 123.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS19004.1 - 4.8e-16 58.6 0.1 1e-15 57.6 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain Hydrolase_4 PF12146.8 KOS19005.1 - 3.6e-10 39.5 0.0 9.1e-10 38.2 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS19005.1 - 9.4e-09 35.3 0.1 1.3e-08 34.8 0.1 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS19005.1 - 2.7e-08 34.7 5.3 2.7e-08 34.7 5.3 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 KOS19005.1 - 0.17 11.4 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Lipase_3 PF01764.25 KOS19005.1 - 0.18 11.7 0.2 0.42 10.5 0.1 1.7 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_5 PF12695.7 KOS19005.1 - 0.19 11.5 0.0 2.1 8.1 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Thioesterase PF00975.20 KOS19005.1 - 4.6 7.3 4.8 4.7 7.2 3.2 1.7 2 0 0 2 2 2 0 Thioesterase domain DUF3543 PF12063.8 KOS19006.1 - 4e-89 298.3 0.8 5.6e-89 297.8 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 KOS19006.1 - 1.3e-61 208.3 0.0 2.5e-61 207.4 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19006.1 - 5.4e-41 140.6 0.0 1.1e-40 139.6 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 KOS19006.1 - 0.066 12.2 0.0 0.099 11.6 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Aminotran_3 PF00202.21 KOS19007.1 - 1.5e-118 396.0 0.0 1.8e-118 395.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 KOS19007.1 - 0.0004 19.7 0.0 0.00086 18.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Voltage_CLC PF00654.20 KOS19009.1 - 5.2e-74 249.6 27.8 3.1e-68 230.6 17.6 3.0 2 1 1 3 3 3 3 Voltage gated chloride channel TMEM238 PF15125.6 KOS19009.1 - 0.017 15.3 1.4 0.071 13.3 1.4 2.1 1 0 0 1 1 1 0 TMEM238 protein family Sas10 PF09368.10 KOS19010.1 - 5.9e-28 97.1 6.7 5.9e-28 97.1 6.7 2.7 2 0 0 2 2 2 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 KOS19010.1 - 2.2e-11 44.2 0.0 1.2e-10 41.9 0.0 2.4 2 0 0 2 2 2 1 Sas10/Utp3/C1D family Vps51 PF08700.11 KOS19011.1 - 2.3e-14 53.2 0.1 1.1e-13 51.0 0.0 2.2 2 0 0 2 2 2 1 Vps51/Vps67 DUF3510 PF12022.8 KOS19011.1 - 0.066 13.6 0.1 0.57 10.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3510) BUD22 PF09073.10 KOS19011.1 - 0.12 11.7 17.8 0.01 15.2 5.7 2.3 2 0 0 2 2 2 0 BUD22 NPR3 PF03666.13 KOS19011.1 - 0.39 9.5 3.7 0.77 8.5 3.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRN3 PF05327.11 KOS19011.1 - 6.3 5.2 9.0 5.8 5.3 2.1 2.6 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 KOS19011.1 - 7 6.4 16.9 0.22 11.3 10.3 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ECH_1 PF00378.20 KOS19012.1 - 4.9e-23 81.7 0.5 5.7e-23 81.5 0.5 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS19012.1 - 2.7e-14 53.4 0.3 2.9e-14 53.3 0.3 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase RNA_pol_I_A49 PF06870.12 KOS19013.1 - 1.1e-85 287.8 1.0 1.5e-85 287.4 1.0 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Pkinase PF00069.25 KOS19014.1 - 3.3e-06 26.7 0.0 4.1e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Amidase_6 PF12671.7 KOS19014.1 - 0.004 17.3 0.0 0.0056 16.8 0.0 1.2 1 0 0 1 1 1 1 Putative amidase domain TraC PF07820.12 KOS19015.1 - 0.023 15.0 3.4 0.036 14.4 3.4 1.3 1 0 0 1 1 1 0 TraC-like protein Glycogen_syn PF05693.13 KOS19016.1 - 0 1174.1 0.0 0 1173.9 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 KOS19016.1 - 1.2e-05 24.9 0.0 0.0014 18.2 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOS19016.1 - 1.3e-05 25.6 0.0 0.0075 16.7 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOS19016.1 - 3.8e-05 23.8 0.1 8e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.11 KOS19016.1 - 0.00025 20.8 0.1 0.00059 19.6 0.1 1.6 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 KOS19016.1 - 0.00059 20.3 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain HCO3_cotransp PF00955.21 KOS19019.1 - 1.8e-77 261.3 12.8 6.5e-40 137.4 0.4 3.0 2 1 1 3 3 3 3 HCO3- transporter family Peptidase_M41 PF01434.18 KOS19020.1 - 5.3e-68 228.6 0.0 8.4e-68 228.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOS19020.1 - 3.4e-30 105.2 0.0 1.1e-29 103.6 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FtsH_ext PF06480.15 KOS19020.1 - 2e-10 41.0 0.0 5.5e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 FtsH Extracellular TIP49 PF06068.13 KOS19020.1 - 0.003 16.8 0.1 0.0068 15.7 0.1 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 KOS19020.1 - 0.012 15.6 0.0 0.04 13.9 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 KOS19020.1 - 0.03 14.9 0.5 2.3 8.8 0.2 2.7 2 1 0 2 2 2 0 AAA domain RuvB_N PF05496.12 KOS19020.1 - 0.031 14.0 0.0 0.087 12.6 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS19020.1 - 0.032 14.6 0.5 0.54 10.6 0.1 2.6 2 1 0 3 3 3 0 AAA ATPase domain AAA_2 PF07724.14 KOS19020.1 - 0.042 14.0 0.0 0.14 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOS19020.1 - 0.11 12.7 0.1 1.3 9.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 KOS19020.1 - 0.17 11.6 0.0 0.35 10.6 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 KOS19020.1 - 0.18 11.3 0.3 0.68 9.5 0.1 2.0 2 0 0 2 2 2 0 AAA domain Guanylate_cyc_2 PF09778.9 KOS19020.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Guanylylate cyclase MTS PF05175.14 KOS19021.1 - 4.9e-08 32.7 0.0 2.4e-07 30.4 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 KOS19021.1 - 2.1e-07 30.8 0.0 8.5e-07 28.9 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19021.1 - 3.1e-05 24.6 0.0 8.1e-05 23.3 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS19021.1 - 4.5e-05 23.3 0.0 8.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain N6_Mtase PF02384.16 KOS19021.1 - 5e-05 22.7 0.0 7.5e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase PrmA PF06325.13 KOS19021.1 - 5.8e-05 22.6 0.0 8.6e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_10 PF05971.12 KOS19021.1 - 0.00019 20.9 0.0 0.00028 20.3 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase PrmC_N PF17827.1 KOS19021.1 - 0.00073 20.1 0.1 0.002 18.7 0.1 1.8 1 0 0 1 1 1 1 PrmC N-terminal domain Met_10 PF02475.16 KOS19021.1 - 0.0025 17.6 0.0 0.004 16.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein UPF0020 PF01170.18 KOS19021.1 - 0.0048 16.6 0.0 0.035 13.8 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 KOS19021.1 - 0.013 16.3 0.0 0.031 15.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOS19021.1 - 0.017 14.4 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOS19021.1 - 0.023 15.4 0.0 0.082 13.6 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOS19021.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain AviRa PF11599.8 KOS19021.1 - 0.087 12.3 0.0 0.3 10.5 0.0 1.7 2 0 0 2 2 2 0 RRNA methyltransferase AviRa RNA_pol_L_2 PF13656.6 KOS19022.1 - 1.7e-21 75.8 0.0 2.1e-21 75.5 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOS19022.1 - 2.2e-06 27.0 0.0 8.1e-06 25.2 0.0 1.9 1 1 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LSM PF01423.22 KOS19023.1 - 1.8e-22 78.8 0.1 1.9e-22 78.7 0.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS19023.1 - 0.091 12.9 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Ataxin 2 SM domain DNA_pol_A_exo1 PF01612.20 KOS19024.1 - 4.8e-11 42.7 0.0 7.4e-11 42.1 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease WD40 PF00400.32 KOS19025.1 - 3.1e-21 75.3 15.7 2.4e-05 25.0 0.2 7.4 7 1 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 KOS19025.1 - 4.6e-16 59.1 0.1 7.6e-16 58.4 0.1 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 KOS19025.1 - 0.082 11.5 0.9 0.7 8.5 0.3 2.5 2 1 0 2 2 2 0 Nucleoporin Nup120/160 AAA PF00004.29 KOS19026.1 - 5.5e-50 169.2 0.0 4e-43 147.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOS19026.1 - 8.8e-05 22.3 0.0 0.00069 19.4 0.0 2.4 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS19026.1 - 0.00044 20.7 0.1 0.019 15.3 0.0 3.0 1 1 1 2 2 2 1 AAA ATPase domain Parvo_NS1 PF01057.17 KOS19026.1 - 0.0007 18.8 0.0 0.0014 17.8 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_lid_3 PF17862.1 KOS19026.1 - 0.00084 19.1 4.8 0.21 11.4 0.2 2.9 3 0 0 3 3 3 2 AAA+ lid domain AAA_25 PF13481.6 KOS19026.1 - 0.0077 15.8 0.0 0.037 13.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOS19026.1 - 0.0089 15.8 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 KOS19026.1 - 0.0098 16.2 0.0 0.034 14.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 KOS19026.1 - 0.01 16.2 0.0 0.046 14.1 0.0 2.2 2 0 0 2 2 1 1 RNA helicase TIP49 PF06068.13 KOS19026.1 - 0.01 15.1 0.0 0.023 13.9 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 KOS19026.1 - 0.024 14.0 0.1 0.058 12.8 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KOS19026.1 - 0.036 13.4 0.0 0.084 12.2 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_2 PF07724.14 KOS19026.1 - 0.044 13.9 0.0 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 KOS19026.1 - 0.052 13.5 0.0 0.18 11.8 0.0 2.0 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 KOS19026.1 - 0.067 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 KOS19026.1 - 0.083 13.1 0.0 0.25 11.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOS19026.1 - 0.092 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.6 KOS19026.1 - 0.1 13.2 0.0 0.23 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOS19026.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 KOS19026.1 - 0.13 12.4 0.0 0.42 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOS19026.1 - 0.16 12.0 0.0 0.43 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain SH3BGR PF04908.15 KOS19027.1 - 2.9e-07 30.6 0.1 1.3e-06 28.5 0.0 2.1 2 0 0 2 2 2 1 SH3-binding, glutamic acid-rich protein Dicty_REP PF05086.12 KOS19027.1 - 0.12 10.4 2.7 0.16 9.9 2.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ATP11 PF06644.11 KOS19028.1 - 2.2e-102 342.5 5.1 1.2e-101 340.1 5.1 1.8 1 1 0 1 1 1 1 ATP11 protein Macoilin PF09726.9 KOS19028.1 - 0.0076 14.9 7.1 0.0093 14.6 7.1 1.1 1 0 0 1 1 1 1 Macoilin family Apt1 PF10351.9 KOS19028.1 - 0.02 13.8 8.1 0.024 13.5 8.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain MAP65_ASE1 PF03999.12 KOS19028.1 - 0.044 12.5 9.3 0.057 12.1 9.3 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SPX PF03105.19 KOS19028.1 - 0.098 12.6 10.2 0.14 12.0 10.2 1.3 1 0 0 1 1 1 0 SPX domain Mucin PF01456.17 KOS19028.1 - 0.14 12.1 20.0 0.27 11.2 20.0 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3827 PF12877.7 KOS19028.1 - 0.26 9.6 11.1 0.5 8.7 10.7 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3827) Miga PF10265.9 KOS19028.1 - 0.62 9.0 5.9 0.8 8.6 5.9 1.1 1 0 0 1 1 1 0 Mitoguardin Rrn6 PF10214.9 KOS19028.1 - 0.76 8.2 17.5 1.1 7.6 17.5 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SAPS PF04499.15 KOS19028.1 - 1.4 7.6 6.7 2 7.1 6.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Hamartin PF04388.12 KOS19028.1 - 2 7.0 10.9 2.6 6.6 10.9 1.2 1 0 0 1 1 1 0 Hamartin protein RAP1 PF07218.11 KOS19028.1 - 2.1 6.5 14.7 2.7 6.2 14.7 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF572 PF04502.13 KOS19028.1 - 2.9 7.4 11.9 0.28 10.8 7.6 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF572) GREB1 PF15782.5 KOS19028.1 - 4.2 4.4 10.0 5.2 4.1 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 KOS19028.1 - 5.1 5.1 9.0 6.5 4.7 9.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ANAPC1 PF12859.7 KOS19028.1 - 6 7.4 13.6 7.7 7.1 12.3 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 1 Herpes_capsid PF06112.11 KOS19028.1 - 6.8 6.7 19.3 14 5.7 19.3 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Sec3_C PF09763.9 KOS19028.1 - 8.7 4.6 6.0 12 4.1 6.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Dicty_REP PF05086.12 KOS19028.1 - 9.4 4.1 7.8 12 3.7 7.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Lin-8 PF03353.15 KOS19028.1 - 9.5 5.7 7.5 17 4.8 7.5 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist FSA_C PF10479.9 KOS19028.1 - 9.9 4.1 14.0 13 3.7 14.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus AMP-binding PF00501.28 KOS19029.1 - 2.9e-98 329.2 0.0 3.7e-98 328.9 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS19029.1 - 5.3e-12 46.6 0.1 1.4e-11 45.2 0.1 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PGA_cap PF09587.10 KOS19029.1 - 0.11 11.9 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap MaoC_dehydratas PF01575.19 KOS19030.1 - 1.9e-05 24.2 0.1 3e-05 23.6 0.1 1.2 1 0 0 1 1 1 1 MaoC like domain Phosphodiest PF01663.22 KOS19031.1 - 1.4e-12 47.9 0.1 1.4e-12 47.9 0.1 1.7 2 0 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOS19031.1 - 0.00019 20.9 0.0 0.00035 20.1 0.0 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 KOS19031.1 - 0.016 14.6 0.3 0.028 13.8 0.3 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily Inj_translocase PF16928.5 KOS19031.1 - 0.72 9.3 6.1 1.3 8.4 6.1 1.3 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome CMAS PF02353.20 KOS19033.1 - 1.2e-62 211.8 0.0 1.4e-62 211.4 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 KOS19033.1 - 2.8e-11 43.9 0.0 5.1e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS19033.1 - 6.9e-11 42.3 0.0 1.1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19033.1 - 3.8e-10 40.3 0.0 6.9e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS19033.1 - 0.00039 21.1 0.0 0.00084 20.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DOT1 PF08123.13 KOS19033.1 - 0.011 15.3 0.0 0.019 14.5 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 KOS19033.1 - 0.014 15.0 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_31 PF13847.6 KOS19033.1 - 0.017 14.9 0.0 0.037 13.8 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOS19033.1 - 0.034 14.1 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOS19033.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MMS19_N PF14500.6 KOS19034.1 - 4.5e-48 164.1 0.2 9.9e-48 163.0 0.2 1.5 1 0 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II MMS19_C PF12460.8 KOS19034.1 - 1.4e-17 64.0 0.0 1.5e-16 60.5 0.0 2.4 2 0 0 2 2 2 1 RNAPII transcription regulator C-terminal Phage_lysis PF03245.13 KOS19034.1 - 0.12 12.5 1.6 0.27 11.4 0.9 1.9 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein TBPIP PF07106.13 KOS19034.1 - 0.14 12.1 0.0 37 4.4 0.0 2.9 2 0 0 2 2 2 0 TBPIP/Hop2 winged helix domain Ribosomal_S9 PF00380.19 KOS19036.1 - 1.9e-38 131.7 0.5 3.1e-38 131.0 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S9/S16 p47_phox_C PF08944.11 KOS19036.1 - 4.8 6.7 6.6 0.28 10.6 0.6 2.1 2 0 0 2 2 2 0 NADPH oxidase subunit p47Phox, C terminal domain EPL1 PF10513.9 KOS19037.1 - 1.8e-08 34.9 4.1 6.1e-06 26.7 0.0 3.4 2 1 1 3 3 3 2 Enhancer of polycomb-like EF-hand_1 PF00036.32 KOS19038.1 - 3.8e-27 91.8 12.7 2.4e-07 29.8 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 KOS19038.1 - 1.2e-23 83.4 14.8 8e-15 55.0 1.3 2.8 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOS19038.1 - 2.5e-21 73.7 6.2 1e-05 25.1 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 KOS19038.1 - 1.9e-18 65.0 10.4 1.7e-06 27.2 0.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 KOS19038.1 - 1e-12 47.7 10.3 0.00013 21.7 0.5 4.2 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOS19038.1 - 4.7e-07 30.1 0.1 0.0011 19.2 0.1 2.3 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 KOS19038.1 - 4.2e-06 26.6 7.7 0.0024 17.8 0.5 3.8 1 1 3 4 4 4 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 KOS19038.1 - 0.0083 16.3 1.0 0.031 14.4 0.9 2.1 1 1 0 1 1 1 1 Dockerin type I domain EF-hand_9 PF14658.6 KOS19038.1 - 0.11 12.9 0.2 4.5 7.7 0.1 2.9 2 1 1 3 3 3 0 EF-hand domain RRP36 PF06102.12 KOS19039.1 - 1.3e-55 187.9 30.1 1.3e-55 187.9 30.1 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 ABC1 PF03109.16 KOS19040.1 - 1.7e-31 108.8 0.0 2.8e-31 108.1 0.0 1.3 1 0 0 1 1 1 1 ABC1 family Pkinase PF00069.25 KOS19040.1 - 0.061 12.7 0.0 3.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein kinase domain EF1G PF00647.19 KOS19041.1 - 1.1e-42 144.4 0.1 3.1e-42 142.9 0.1 1.8 2 0 0 2 2 2 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 KOS19041.1 - 2.6e-13 50.0 0.0 6e-13 48.8 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOS19041.1 - 1.5e-09 37.7 3.4 2.3e-09 37.2 0.1 2.6 3 0 0 3 3 3 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOS19041.1 - 1.2e-07 31.9 0.0 2.5e-07 30.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOS19041.1 - 0.00011 22.3 0.0 0.00052 20.2 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOS19041.1 - 0.0097 16.3 0.0 0.022 15.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_6 PF17171.4 KOS19041.1 - 0.031 14.1 0.2 1.7 8.5 0.0 2.5 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KOS19041.1 - 0.032 14.5 0.0 0.058 13.7 0.0 1.4 1 0 0 1 1 1 0 Outer mitochondrial membrane transport complex protein NIF PF03031.18 KOS19042.1 - 1.1e-18 67.5 0.0 1.5e-18 67.1 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Bac_GH3_C PF18034.1 KOS19042.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial Glycosyl hydrolase family 3 C-terminal domain Retinal PF15449.6 KOS19042.1 - 4.5 4.9 15.0 5.7 4.6 15.0 1.0 1 0 0 1 1 1 0 Retinal protein AMPK1_CBM PF16561.5 KOS19043.1 - 1.3e-25 89.4 0.0 1.3e-25 89.4 0.0 1.9 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 KOS19043.1 - 8.8e-25 86.8 2.5 8.8e-25 86.8 2.5 3.4 2 1 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain Apt1 PF10351.9 KOS19043.1 - 0.27 10.0 27.4 0.008 15.1 5.6 3.0 3 0 0 3 3 3 0 Golgi-body localisation protein domain DUF853 PF05872.12 KOS19043.1 - 1.1 7.7 4.9 1.9 7.0 4.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Otopetrin PF03189.13 KOS19043.1 - 2.5 6.8 12.9 0.21 10.4 7.6 1.8 2 0 0 2 2 2 0 Otopetrin Membralin PF09746.9 KOS19043.1 - 6.1 5.8 7.4 12 4.8 7.4 1.4 1 0 0 1 1 1 0 Tumour-associated protein AUX_IAA PF02309.16 KOS19043.1 - 6.8 6.5 18.9 0.03 14.2 7.1 2.5 3 0 0 3 3 3 0 AUX/IAA family Peptidase_M22 PF00814.25 KOS19044.1 - 1.2e-80 271.2 0.0 1.5e-80 270.8 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family G-patch_2 PF12656.7 KOS19045.1 - 6.6e-19 67.8 0.5 6.6e-19 67.8 0.5 3.4 3 0 0 3 3 3 1 G-patch domain Fes1 PF08609.10 KOS19045.1 - 0.12 13.2 0.9 0.62 11.0 0.7 2.3 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 Na_H_Exchanger PF00999.21 KOS19047.1 - 1.5e-74 251.1 41.7 1.9e-74 250.7 41.7 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Arf PF00025.21 KOS19048.1 - 7.8e-39 132.9 0.1 1.4e-24 86.5 0.0 2.0 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 KOS19048.1 - 6.3e-12 45.3 0.0 1.8e-06 27.4 0.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 KOS19048.1 - 1.1e-07 32.1 0.0 3.9e-07 30.3 0.0 1.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOS19048.1 - 2.6e-07 30.3 0.0 2.9e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOS19048.1 - 3.2e-07 30.0 0.0 5.4e-05 22.7 0.0 2.1 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Ras PF00071.22 KOS19048.1 - 3.9e-07 29.8 0.0 0.0066 16.0 0.0 2.2 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 KOS19048.1 - 0.0022 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS19048.1 - 0.0029 17.2 0.0 0.01 15.4 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RNase_PH PF01138.21 KOS19049.1 - 2e-25 89.8 0.0 2.8e-25 89.3 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOS19049.1 - 1.7e-05 24.7 0.0 2.8e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Cwf_Cwc_15 PF04889.12 KOS19050.1 - 1.7e-75 254.0 48.3 7e-74 248.7 48.3 2.1 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 KOS19050.1 - 0.52 8.3 42.4 0.75 7.8 42.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 KOS19050.1 - 0.77 7.9 38.0 0.94 7.6 38.0 1.1 1 0 0 1 1 1 0 Nop14-like family FGGY_C PF02782.16 KOS19051.1 - 1.6e-21 76.9 0.1 3.9e-21 75.7 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOS19051.1 - 1.1e-17 64.4 0.0 1.8e-09 37.6 0.0 2.9 3 1 0 3 3 3 2 FGGY family of carbohydrate kinases, N-terminal domain Cation_efflux PF01545.21 KOS19052.1 - 2.2e-49 167.9 3.0 2.2e-49 167.9 3.0 2.2 2 0 0 2 2 2 1 Cation efflux family ZT_dimer PF16916.5 KOS19052.1 - 2.1e-05 24.5 0.0 5.9e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Rax2 PF12768.7 KOS19052.1 - 1.1 8.7 2.4 2.1 7.7 2.4 1.4 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Spt20 PF12090.8 KOS19052.1 - 1.9 8.0 5.8 2.7 7.5 5.8 1.1 1 0 0 1 1 1 0 Spt20 family SIR2 PF02146.17 KOS19053.1 - 3.1e-29 102.1 0.0 4.7e-29 101.6 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF5321 PF17254.2 KOS19054.1 - 4.7e-56 188.6 0.4 5.9e-56 188.3 0.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5321) UPF0492 PF15744.5 KOS19054.1 - 0.13 11.5 5.7 0.16 11.1 5.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 Dak1 PF02733.17 KOS19055.1 - 8.3e-101 337.0 6.3 1.2e-100 336.5 6.3 1.2 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 KOS19055.1 - 2.2e-45 154.7 0.0 4.7e-45 153.6 0.0 1.6 1 0 0 1 1 1 1 DAK2 domain Serglycin PF04360.12 KOS19055.1 - 1.2 9.0 3.1 2.6 8.0 3.1 1.4 1 0 0 1 1 1 0 Serglycin CVNH PF08881.10 KOS19056.1 - 3.8e-32 111.0 0.0 1.2e-31 109.4 0.0 1.9 1 1 0 1 1 1 1 CVNH domain LysM PF01476.20 KOS19056.1 - 2.8e-16 59.3 0.0 6.1e-16 58.2 0.0 1.6 1 0 0 1 1 1 1 LysM domain Rick_17kDa_Anti PF05433.15 KOS19056.1 - 5.5e-06 26.1 17.0 5.5e-06 26.1 17.0 2.3 2 0 0 2 2 2 1 Glycine zipper 2TM domain TraT PF05818.12 KOS19056.1 - 0.0005 19.8 0.1 0.001 18.8 0.1 1.6 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein Gly-zipper_Omp PF13488.6 KOS19056.1 - 0.0012 18.8 14.5 0.0012 18.8 14.5 2.8 3 0 0 3 3 3 1 Glycine zipper DUF533 PF04391.12 KOS19056.1 - 0.021 14.4 0.1 0.021 14.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF533) ATP-synt_E PF05680.12 KOS19056.1 - 0.57 10.6 3.1 1.3 9.4 3.1 1.6 1 0 0 1 1 1 0 ATP synthase E chain DUF2076 PF09849.9 KOS19056.1 - 3.5 7.6 28.2 22 5.0 28.2 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DCP2 PF05026.13 KOS19057.1 - 1.8e-30 105.1 0.8 2.8e-30 104.4 0.8 1.3 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 KOS19057.1 - 1.3e-16 60.8 0.2 3e-16 59.6 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain Metallophos PF00149.28 KOS19058.1 - 1.9e-08 35.1 0.0 4e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase zf-ISL3 PF14690.6 KOS19058.1 - 0.17 12.6 0.6 0.6 10.8 0.6 1.9 1 0 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 CLTH PF10607.9 KOS19059.1 - 4.7e-36 123.9 0.0 7.1e-36 123.3 0.0 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 KOS19059.1 - 3.3e-05 23.7 0.9 0.0001 22.1 0.1 2.2 2 0 0 2 2 2 1 LisH zf-C2H2_9 PF16293.5 KOS19059.1 - 0.024 14.5 0.1 0.061 13.2 0.1 1.7 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) DUF4129 PF13559.6 KOS19059.1 - 4 7.8 9.0 34 4.8 0.2 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4129) DUF1674 PF07896.12 KOS19060.1 - 1.4e-18 67.1 1.1 3.1e-18 66.0 1.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1674) SPX PF03105.19 KOS19060.1 - 1.6 8.5 13.9 1.7 8.5 13.9 1.0 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 KOS19060.1 - 2.1 7.1 11.5 2.2 7.1 11.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 KOS19060.1 - 3.8 5.9 10.5 4.1 5.9 10.5 1.0 1 0 0 1 1 1 0 Macoilin family SSP160 PF06933.11 KOS19060.1 - 4 5.5 13.7 4.3 5.4 13.7 1.0 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Presenilin PF01080.17 KOS19060.1 - 4.6 5.9 4.2 5.1 5.8 4.2 1.0 1 0 0 1 1 1 0 Presenilin RAP1 PF07218.11 KOS19060.1 - 6.8 4.8 18.9 7.5 4.7 18.9 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) NmrA PF05368.13 KOS19061.1 - 7.3e-25 87.9 0.0 9.5e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOS19061.1 - 1e-09 38.5 3.3 3.1e-09 37.0 3.3 1.8 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOS19061.1 - 3.9e-06 26.5 0.1 0.048 13.1 0.0 2.3 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family KR PF08659.10 KOS19061.1 - 0.00087 19.3 0.1 0.0014 18.6 0.1 1.3 1 0 0 1 1 1 1 KR domain O-antigen_lig PF13425.6 KOS19062.1 - 0.29 9.9 1.6 0.51 9.1 1.6 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3391 PF11871.8 KOS19062.1 - 0.72 10.4 11.3 3.5 8.2 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) ZapB PF06005.12 KOS19062.1 - 4.3 7.9 0.0 4.3 7.9 0.0 3.6 3 1 0 3 3 3 0 Cell division protein ZapB CAF1 PF04857.20 KOS19064.1 - 3.7e-25 88.8 0.1 1.4e-11 44.1 0.0 3.0 3 0 0 3 3 3 2 CAF1 family ribonuclease CbiD PF01888.17 KOS19064.1 - 0.017 14.4 8.9 0.043 13.1 0.2 2.3 2 0 0 2 2 2 0 CbiD DUF5421 PF17458.2 KOS19064.1 - 0.075 12.4 3.9 0.37 10.1 4.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5421) DUF1467 PF07330.12 KOS19064.1 - 0.16 11.9 0.8 0.43 10.5 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1467) TFIIA PF03153.13 KOS19064.1 - 0.36 10.8 31.0 0.35 10.8 21.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF3824 PF12868.7 KOS19064.1 - 1.4 9.6 12.5 1 10.0 5.3 2.4 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Trp_oprn_chp PF09534.10 KOS19064.1 - 2.7 7.8 13.9 3 7.6 8.6 2.3 2 0 0 2 2 2 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF3391 PF11871.8 KOS19064.1 - 2.9 8.4 8.6 1.8 9.1 4.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) RskA PF10099.9 KOS19064.1 - 3.6 7.8 36.4 0.17 12.2 1.1 3.1 2 1 0 2 2 2 0 Anti-sigma-K factor rskA FHIPEP PF00771.20 KOS19064.1 - 7.1 5.0 6.8 0.54 8.7 2.1 1.4 2 0 0 2 2 2 0 FHIPEP family NDUF_B12 PF08122.12 KOS19065.1 - 6.3e-24 83.8 1.3 8.7e-24 83.3 1.3 1.2 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B12 subunit family ThiF PF00899.21 KOS19066.1 - 7.2e-22 77.9 0.0 1.6e-10 40.8 0.0 2.3 2 1 0 2 2 2 2 ThiF family E1_4HB PF16191.5 KOS19066.1 - 0.04 14.1 0.1 0.2 11.9 0.0 2.1 3 0 0 3 3 3 0 Ubiquitin-activating enzyme E1 four-helix bundle DUF871 PF05913.11 KOS19067.1 - 0.07 12.3 0.0 0.1 11.7 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF871) Apolipoprotein PF01442.18 KOS19067.1 - 0.96 9.3 8.4 0.48 10.3 1.7 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Ras PF00071.22 KOS19068.1 - 5.6e-58 195.1 0.1 6.5e-58 194.9 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS19068.1 - 6e-36 123.3 0.1 1e-35 122.5 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS19068.1 - 1.3e-14 54.1 0.0 1.5e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOS19068.1 - 1.6e-06 27.7 0.0 1.9e-06 27.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS19068.1 - 2.7e-06 27.4 0.0 4.1e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS19068.1 - 3e-06 26.9 0.0 4.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS19068.1 - 3.3e-05 23.8 0.8 0.18 11.7 0.1 2.4 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 KOS19068.1 - 0.023 15.1 0.2 0.044 14.2 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 KOS19068.1 - 0.086 12.2 0.0 0.19 11.1 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein G-alpha PF00503.20 KOS19068.1 - 0.11 11.6 0.2 1.2 8.2 0.0 2.1 1 1 1 2 2 2 0 G-protein alpha subunit GbpA_2 PF18416.1 KOS19068.1 - 0.17 12.2 1.2 7.4 6.9 1.2 2.3 1 1 0 1 1 1 0 N-acetylglucosamine binding protein domain 2 Gly_transf_sug PF04488.15 KOS19069.1 - 1.7e-11 44.6 0.1 5.9e-11 42.9 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif DUF1289 PF06945.13 KOS19069.1 - 0.1 12.4 1.2 0.31 10.9 1.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) DUF4230 PF14014.6 KOS19069.1 - 0.16 12.2 0.3 0.35 11.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) Mur_ligase_M PF08245.12 KOS19070.1 - 0.0007 19.6 0.3 0.008 16.2 0.3 2.4 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KOS19070.1 - 0.0047 17.1 0.0 0.022 15.0 0.0 2.1 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Phage_P2_GpE PF06528.12 KOS19070.1 - 0.19 11.3 1.9 0.55 9.8 0.2 2.6 2 1 1 3 3 3 0 Phage P2 GpE Mitofilin PF09731.9 KOS19071.1 - 3e-142 475.6 32.3 1.1e-120 404.4 19.5 2.8 2 1 1 3 3 3 2 Mitochondrial inner membrane protein Pex14_N PF04695.13 KOS19071.1 - 0.0014 19.3 6.3 0.0014 19.3 6.3 2.5 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PrkA PF06798.12 KOS19071.1 - 0.016 14.8 4.3 0.028 14.1 4.3 1.3 1 0 0 1 1 1 0 PrkA serine protein kinase C-terminal domain NaeI PF09126.10 KOS19071.1 - 0.028 13.6 1.9 0.049 12.8 0.7 2.0 2 1 0 2 2 2 0 Restriction endonuclease NaeI 4HB_MCP_1 PF12729.7 KOS19071.1 - 0.16 11.5 6.5 0.26 10.8 5.3 1.9 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction JIP_LZII PF16471.5 KOS19071.1 - 1.7 8.9 7.4 0.097 12.9 0.5 2.5 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II FAM76 PF16046.5 KOS19071.1 - 3.4 7.0 4.7 6.7 6.0 4.7 1.4 1 0 0 1 1 1 0 FAM76 protein Syja_N PF02383.18 KOS19072.1 - 2.3e-85 286.7 0.0 3e-85 286.3 0.0 1.1 1 0 0 1 1 1 1 SacI homology domain Acyl_transf_3 PF01757.22 KOS19074.1 - 6.7e-31 107.6 26.1 8.4e-31 107.3 26.1 1.1 1 0 0 1 1 1 1 Acyltransferase family FA_desaturase PF00487.24 KOS19076.1 - 0.19 11.5 1.0 0.19 11.5 1.0 1.0 1 0 0 1 1 1 0 Fatty acid desaturase RTX PF02382.15 KOS19076.1 - 1.9 8.1 5.7 2.1 7.9 5.7 1.1 1 0 0 1 1 1 0 N-terminal domain in RTX protein tRNA-synt_1 PF00133.22 KOS19077.1 - 6.6e-143 477.1 0.0 1e-142 476.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOS19077.1 - 2.2e-16 59.6 0.0 1.1e-09 37.5 0.0 4.0 4 0 0 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOS19077.1 - 1.9e-15 57.1 0.0 3.2e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 KOS19077.1 - 0.032 13.7 0.0 0.056 12.9 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 zf-FPG_IleRS PF06827.14 KOS19077.1 - 0.058 13.3 3.1 0.15 11.9 3.1 1.8 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS CENP-I PF07778.11 KOS19079.1 - 0.19 10.4 1.7 0.35 9.5 1.7 1.4 1 0 0 1 1 1 0 Mis6 FancD2 PF14631.6 KOS19079.1 - 1.4 6.2 5.5 2.7 5.3 5.5 1.4 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Csm4_C PF17953.1 KOS19081.1 - 0.079 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 CRISPR Csm4 C-terminal domain Methyltransf_11 PF08241.12 KOS19082.1 - 4.4e-11 43.3 0.2 9.8e-11 42.2 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19082.1 - 3.1e-10 40.6 0.2 1.3e-09 38.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS19082.1 - 2.7e-06 28.1 0.0 1.4e-05 25.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS19082.1 - 1.5e-05 24.9 0.0 2e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS19082.1 - 0.0072 15.7 0.0 0.014 14.8 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family DUF5315 PF17242.2 KOS19082.1 - 0.013 15.3 0.5 0.03 14.1 0.1 1.8 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) Methyltransf_31 PF13847.6 KOS19082.1 - 0.096 12.5 0.0 0.23 11.2 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain DREV PF05219.12 KOS19082.1 - 0.1 11.7 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 DREV methyltransferase RrnaAD PF00398.20 KOS19082.1 - 0.12 11.5 0.0 0.18 10.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase LSM PF01423.22 KOS19083.1 - 2.9e-20 71.7 0.1 3.4e-20 71.5 0.1 1.1 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS19083.1 - 0.0003 20.9 0.1 0.00038 20.6 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 KOS19083.1 - 0.00031 20.8 0.1 0.00037 20.5 0.1 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain Rad60-SLD PF11976.8 KOS19084.1 - 2.1e-14 53.1 0.1 3.7e-14 52.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOS19084.1 - 0.001 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family TmoB PF06234.12 KOS19084.1 - 0.082 13.0 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Toluene-4-monooxygenase system protein B (TmoB) SIR2 PF02146.17 KOS19085.1 - 3.1e-25 89.1 0.0 1e-24 87.4 0.0 1.9 1 1 0 1 1 1 1 Sir2 family MCR PF18509.1 KOS19085.1 - 0.022 14.4 0.2 0.022 14.4 0.2 2.0 2 0 0 2 2 2 0 Magnetochrome domain TPP_enzyme_M PF00205.22 KOS19085.1 - 0.067 12.9 0.1 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, central domain Rhomboid PF01694.22 KOS19086.1 - 1.4e-20 73.9 11.5 2.6e-20 72.9 11.5 1.5 1 0 0 1 1 1 1 Rhomboid family CPSF100_C PF13299.6 KOS19087.1 - 0.45 10.7 3.0 0.66 10.1 3.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 KOS19087.1 - 1 8.0 3.1 1.2 7.8 3.1 1.1 1 0 0 1 1 1 0 Presenilin FAM75 PF14650.6 KOS19087.1 - 1.3 8.5 8.3 1.9 8.0 8.3 1.2 1 0 0 1 1 1 0 FAM75 family Spt20 PF12090.8 KOS19087.1 - 5 6.7 11.7 8.2 6.0 11.7 1.2 1 0 0 1 1 1 0 Spt20 family DUF4112 PF13430.6 KOS19088.1 - 3.6e-34 117.2 0.3 4.7e-34 116.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) Ribonuc_red_sm PF00268.21 KOS19089.1 - 5.8e-121 403.2 2.1 7.1e-121 402.9 2.1 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF4744 PF15918.5 KOS19089.1 - 0.15 12.9 0.0 0.35 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) SRP9-21 PF05486.12 KOS19090.1 - 5.5e-34 116.4 0.1 5.5e-34 116.4 0.1 1.9 2 0 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) WD40 PF00400.32 KOS19091.1 - 1.5e-16 60.4 8.2 3e-08 34.2 0.7 5.8 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19091.1 - 1.5e-06 28.4 0.0 0.27 11.6 0.0 4.5 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 KOS19091.1 - 0.051 12.3 0.0 6 5.5 0.0 2.2 1 1 1 2 2 2 0 Nup133 N terminal like CVNH PF08881.10 KOS19092.1 - 5.2e-16 59.2 0.0 6.1e-16 58.9 0.0 1.1 1 0 0 1 1 1 1 CVNH domain Phage_fiber_C PF06820.12 KOS19092.1 - 0.15 12.5 0.1 0.41 11.0 0.1 1.7 2 0 0 2 2 2 0 Putative prophage tail fibre C-terminus Mito_carr PF00153.27 KOS19094.1 - 2.4e-54 181.3 0.6 5.6e-18 64.7 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein CTU2 PF10288.9 KOS19095.1 - 3.3e-10 40.2 0.0 1.5e-09 38.1 0.0 2.0 1 1 0 1 1 1 1 Cytoplasmic tRNA 2-thiolation protein 2 PH PF00169.29 KOS19096.1 - 9e-26 90.4 1.7 1.3e-13 51.3 0.1 2.3 2 0 0 2 2 2 2 PH domain PH_9 PF15410.6 KOS19096.1 - 8.7e-10 39.0 2.9 6.8e-05 23.2 1.0 3.4 2 2 0 2 2 2 2 Pleckstrin homology domain PH_11 PF15413.6 KOS19096.1 - 5.7e-09 36.4 6.0 0.0009 19.6 1.0 3.3 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 KOS19096.1 - 0.00035 20.8 0.3 0.00088 19.5 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Med2 PF11214.8 KOS19097.1 - 0.056 13.6 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 2 MCM PF00493.23 KOS19099.1 - 2.5e-105 350.5 0.1 8.5e-105 348.8 0.0 1.9 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 KOS19099.1 - 9.3e-36 122.5 0.8 1.9e-35 121.5 0.8 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOS19099.1 - 4.2e-28 97.6 2.2 1e-27 96.3 2.2 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOS19099.1 - 7.6e-17 61.8 0.9 2e-16 60.5 0.9 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOS19099.1 - 2e-06 27.4 0.0 0.0002 20.8 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOS19099.1 - 8.8e-06 25.8 0.0 2.3e-05 24.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOS19099.1 - 0.00015 21.7 0.1 0.00074 19.4 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 KOS19099.1 - 0.033 14.6 0.1 0.11 12.9 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS19099.1 - 0.053 13.2 0.0 1.2 8.8 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 KOS19099.1 - 0.36 11.2 1.8 3.5 8.0 0.0 2.7 2 1 1 3 3 3 0 AAA ATPase domain Utp13 PF08625.11 KOS19101.1 - 6e-52 175.3 0.1 1e-51 174.6 0.1 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 KOS19101.1 - 4.3e-46 153.9 28.7 6.6e-05 23.6 0.1 11.4 10 1 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19101.1 - 8.6e-12 45.2 9.6 0.016 15.5 0.0 8.2 6 2 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS19101.1 - 1.3e-06 27.4 4.8 0.12 11.0 0.3 5.7 4 2 1 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 KOS19101.1 - 3.2e-06 26.1 2.1 1.6 7.4 0.0 5.2 4 1 0 5 5 5 3 Nup133 N terminal like WD40_like PF17005.5 KOS19101.1 - 0.0061 15.9 0.0 5.9 6.1 0.0 3.7 3 1 1 4 4 4 1 WD40-like domain eIF2A PF08662.11 KOS19101.1 - 0.13 12.1 0.0 0.73 9.7 0.0 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A UCH PF00443.29 KOS19102.1 - 1e-25 90.7 0.0 1.4e-25 90.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOS19102.1 - 1.1e-11 44.9 0.3 1.1e-11 44.9 0.3 1.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 KOS19102.1 - 0.0082 15.8 0.1 0.073 12.7 0.1 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CRISPR_assoc PF08798.11 KOS19102.1 - 0.048 13.7 0.3 0.16 12.0 0.2 1.9 2 0 0 2 2 2 0 CRISPR associated protein IF4E PF01652.18 KOS19103.1 - 1.4e-52 177.7 0.0 2e-52 177.2 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E TIMELESS PF04821.14 KOS19104.1 - 9.2e-85 284.2 0.0 9.2e-85 284.2 0.0 2.2 3 0 0 3 3 3 1 Timeless protein TIMELESS_C PF05029.13 KOS19104.1 - 3.2e-27 95.9 21.6 3.2e-27 95.9 21.6 4.2 2 1 1 3 3 3 1 Timeless protein C terminal region Cnd1_N PF12922.7 KOS19104.1 - 0.14 12.0 6.0 2.9 7.7 0.0 3.7 3 0 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1, N-term 3HCDH_N PF02737.18 KOS19105.1 - 2.2e-51 174.3 0.7 2.8e-51 173.9 0.7 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 KOS19105.1 - 2.8e-33 114.4 0.0 9.4e-33 112.7 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Sacchrp_dh_NADP PF03435.18 KOS19105.1 - 0.00015 22.0 0.2 0.00034 20.9 0.1 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 KOS19105.1 - 0.0094 16.1 0.2 0.031 14.5 0.2 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase DAO PF01266.24 KOS19105.1 - 0.09 12.3 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Homeodomain PF00046.29 KOS19106.1 - 6.3e-18 64.4 2.9 1.1e-17 63.7 2.9 1.3 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 KOS19106.1 - 0.0055 16.6 1.4 0.008 16.1 0.1 1.9 2 0 0 2 2 2 1 Homeobox KN domain Rox3 PF08633.10 KOS19107.1 - 4.7e-41 141.3 0.1 1.1e-40 140.1 0.0 1.6 2 0 0 2 2 2 1 Rox3 mediator complex subunit HEAT PF02985.22 KOS19108.1 - 0.0045 17.1 1.7 11 6.6 0.1 5.7 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 KOS19108.1 - 0.011 16.1 7.4 3.6 8.0 0.0 6.0 6 1 0 6 6 6 0 HEAT repeats DUF2682 PF10909.8 KOS19108.1 - 0.05 14.1 0.6 0.73 10.4 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2682) Pkinase PF00069.25 KOS19109.1 - 1.3e-49 169.0 0.0 1.8e-49 168.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19109.1 - 8.3e-28 97.4 0.0 1.1e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19109.1 - 0.0014 18.0 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOS19109.1 - 0.02 14.2 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 KOS19109.1 - 0.14 11.7 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pkinase PF00069.25 KOS19110.1 - 5.6e-54 183.3 0.0 1.5e-48 165.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19110.1 - 6.5e-33 114.1 0.0 4e-31 108.2 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19110.1 - 5e-09 35.9 0.0 6e-08 32.3 0.0 2.0 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOS19110.1 - 0.00013 22.0 1.1 0.00025 21.1 0.1 2.0 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOS19110.1 - 0.01 14.7 0.0 0.022 13.6 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase UPF0731 PF14982.6 KOS19110.1 - 0.079 13.1 0.0 0.34 11.1 0.0 2.1 1 0 0 1 1 1 0 UPF0731 family EF-hand_7 PF13499.6 KOS19110.1 - 0.16 12.4 0.0 0.53 10.8 0.0 1.9 1 0 0 1 1 1 0 EF-hand domain pair Sybindin PF04099.12 KOS19111.1 - 3e-22 79.1 0.0 4.2e-22 78.6 0.0 1.2 1 0 0 1 1 1 1 Sybindin-like family Peroxin-3 PF04882.12 KOS19112.1 - 1.1e-160 535.8 0.0 1.2e-160 535.6 0.0 1.0 1 0 0 1 1 1 1 Peroxin-3 SAT PF16073.5 KOS19112.1 - 0.011 15.5 0.2 0.026 14.2 0.1 1.6 2 0 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis ATG101 PF07855.12 KOS19113.1 - 8.4e-57 191.5 0.0 1e-56 191.2 0.0 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Mo-co_dimer PF03404.16 KOS19113.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Mo-co oxidoreductase dimerisation domain Forkhead PF00250.18 KOS19114.1 - 2.8e-35 120.4 0.1 4.1e-35 119.9 0.1 1.2 1 0 0 1 1 1 1 Forkhead domain EF-hand_4 PF12763.7 KOS19115.1 - 2.4e-26 91.7 0.0 2.8e-14 52.9 0.0 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand WH2 PF02205.20 KOS19115.1 - 8.3e-07 28.7 0.9 5.6e-05 22.8 0.1 2.8 2 0 0 2 2 2 1 WH2 motif DUF1720 PF08226.11 KOS19115.1 - 0.00025 21.4 77.8 0.00066 20.0 39.6 9.2 6 3 3 9 9 9 3 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 KOS19115.1 - 0.00034 21.0 0.2 0.099 13.1 0.0 3.1 3 0 0 3 3 3 1 EF-hand domain pair E3_binding PF02817.17 KOS19115.1 - 0.045 14.1 0.1 0.13 12.6 0.1 1.8 1 0 0 1 1 1 0 e3 binding domain RXT2_N PF08595.11 KOS19116.1 - 0.038 14.0 1.2 0.038 14.0 1.2 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Nucleo_P87 PF07267.11 KOS19116.1 - 0.16 10.8 1.1 0.24 10.2 1.1 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM176 PF14851.6 KOS19116.1 - 0.28 10.9 1.6 0.72 9.5 1.6 1.7 1 0 0 1 1 1 0 FAM176 family LRR_4 PF12799.7 KOS19116.1 - 0.84 10.1 7.9 8.9 6.9 0.8 3.9 2 2 3 5 5 5 0 Leucine Rich repeats (2 copies) Cwf_Cwc_15 PF04889.12 KOS19116.1 - 1.9 8.1 16.4 1.4 8.6 8.8 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PIF1 PF05970.14 KOS19119.1 - 3.3e-60 204.2 0.1 3.9e-57 194.1 0.1 2.2 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 KOS19119.1 - 1.7e-24 86.6 0.0 3e-24 85.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS19119.1 - 6.5e-11 42.8 0.0 1.2e-10 41.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS19119.1 - 1.2e-07 32.0 0.0 2.7e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KOS19119.1 - 4.3e-06 26.4 0.0 8.3e-06 25.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region UvrD_C_2 PF13538.6 KOS19119.1 - 0.00013 21.7 0.1 0.00031 20.5 0.1 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_16 PF13191.6 KOS19119.1 - 0.00038 20.9 0.0 0.00087 19.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 KOS19119.1 - 0.0004 20.8 0.0 0.00079 19.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 KOS19119.1 - 0.00042 19.5 0.0 0.00072 18.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_11 PF13086.6 KOS19119.1 - 0.00045 20.1 0.3 0.0057 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Herpes_Helicase PF02689.14 KOS19119.1 - 0.00093 17.3 0.1 0.0028 15.7 0.0 1.6 2 0 0 2 2 2 1 Helicase PhoH PF02562.16 KOS19119.1 - 0.0023 17.4 0.0 0.0043 16.5 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein ABC_tran PF00005.27 KOS19119.1 - 0.0047 17.4 0.0 0.011 16.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter Viral_helicase1 PF01443.18 KOS19119.1 - 0.0091 15.8 0.4 0.32 10.7 0.0 2.7 3 0 0 3 3 2 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 KOS19119.1 - 0.01 15.1 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 KOS19119.1 - 0.012 15.5 0.0 0.027 14.4 0.0 1.6 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 KOS19119.1 - 0.015 15.3 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 KOS19119.1 - 0.015 15.7 0.0 0.03 14.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 KOS19119.1 - 0.017 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_29 PF13555.6 KOS19119.1 - 0.024 14.4 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 KOS19119.1 - 0.028 14.5 0.0 0.14 12.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOS19119.1 - 0.029 13.6 0.0 0.074 12.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 KOS19119.1 - 0.046 13.4 0.2 0.11 12.2 0.1 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 KOS19119.1 - 0.071 13.0 0.1 0.25 11.2 0.0 1.9 2 0 0 2 2 2 0 NTPase AAA_5 PF07728.14 KOS19119.1 - 0.089 12.8 0.2 0.7 9.9 0.2 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SH3_13 PF18335.1 KOS19119.1 - 0.12 12.2 0.1 0.37 10.7 0.0 1.8 2 0 0 2 2 1 0 ATP-dependent RecD-like DNA helicase SH3 domain IstB_IS21 PF01695.17 KOS19119.1 - 0.15 11.8 0.0 0.64 9.7 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein TsaE PF02367.17 KOS19119.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 KOS19119.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase Parvo_NS1 PF01057.17 KOS19119.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TIP49 PF06068.13 KOS19119.1 - 0.2 10.8 0.0 1.7 7.8 0.0 2.2 3 0 0 3 3 3 0 TIP49 P-loop domain DUF815 PF05673.13 KOS19119.1 - 0.21 10.7 0.0 0.62 9.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) SUIM_assoc PF16619.5 KOS19119.1 - 0.29 11.2 4.0 0.24 11.5 2.0 1.9 2 0 0 2 2 1 0 Unstructured region C-term to UIM in Ataxin3 IRF PF00605.17 KOS19120.1 - 0.084 13.2 0.7 0.39 11.0 0.2 2.1 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor DUF2477 PF10631.9 KOS19120.1 - 0.61 10.8 5.6 0.42 11.3 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2477) Cullin PF00888.22 KOS19121.1 - 2.9e-156 521.7 0.0 5.2e-155 517.5 0.0 2.0 1 1 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 KOS19121.1 - 5.3e-24 84.0 0.2 1.2e-23 82.9 0.2 1.7 1 0 0 1 1 1 1 Cullin protein neddylation domain EF1_GNE PF00736.19 KOS19122.1 - 4.4e-33 113.3 0.8 7.1e-33 112.6 0.8 1.3 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 KOS19122.1 - 2.2e-14 53.6 9.1 2.2e-14 53.6 9.1 2.6 2 0 0 2 2 2 1 Eukaryotic elongation factor 1 beta central acidic region GST_C_3 PF14497.6 KOS19122.1 - 0.00023 21.3 0.5 0.0014 18.8 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS19122.1 - 0.0014 18.8 2.2 0.0019 18.4 0.1 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain ABC_tran PF00005.27 KOS19123.1 - 3.1e-33 115.2 0.0 5.6e-33 114.4 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOS19123.1 - 6e-25 88.4 4.3 1.7e-24 86.9 3.6 2.1 2 0 0 2 2 2 1 ABC transporter transmembrane region RsgA_GTPase PF03193.16 KOS19123.1 - 0.011 15.6 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SMC_N PF02463.19 KOS19123.1 - 0.033 13.6 0.0 0.1 12.0 0.0 1.7 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS19123.1 - 0.051 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 KOS19123.1 - 0.17 12.1 0.2 3 8.1 0.2 2.7 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit TRAM_LAG1_CLN8 PF03798.16 KOS19124.1 - 5.4e-38 130.7 16.6 9.3e-38 130.0 16.6 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 KOS19124.1 - 2.5e-27 94.3 0.0 6.8e-27 92.9 0.0 1.8 1 0 0 1 1 1 1 TRAM1-like protein PalH PF08733.10 KOS19125.1 - 1.5e-109 366.0 0.0 1.8e-109 365.7 0.0 1.1 1 0 0 1 1 1 1 PalH/RIM21 Cwf_Cwc_15 PF04889.12 KOS19125.1 - 0.12 12.1 6.9 0.026 14.3 3.6 1.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 KOS19125.1 - 1.5 6.8 7.1 2.2 6.3 7.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 KOS19125.1 - 2.2 6.4 3.9 3.2 5.9 3.9 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 KOS19125.1 - 4.9 7.6 15.8 0.42 11.0 6.8 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YjeF_N PF03853.15 KOS19126.1 - 9.8e-37 126.5 0.0 1.8e-36 125.6 0.0 1.5 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 KOS19126.1 - 4.6e-08 33.9 0.3 4.6e-08 33.9 0.3 2.2 2 0 0 2 2 2 1 FDF domain RAP80_UIM PF18282.1 KOS19126.1 - 0.051 13.3 2.2 0.13 12.0 2.2 1.6 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif NVEALA PF14055.6 KOS19126.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 NVEALA protein APH PF01636.23 KOS19127.1 - 0.00059 19.8 0.0 0.00095 19.2 0.0 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sod_Fe_C PF02777.18 KOS19128.1 - 4.3e-37 126.4 0.1 6.9e-37 125.7 0.1 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 KOS19128.1 - 1e-28 99.6 0.4 1.6e-28 98.9 0.4 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain JmjC PF02373.22 KOS19129.1 - 1.8e-21 76.7 0.0 6e-21 75.0 0.0 1.8 2 0 0 2 2 2 1 JmjC domain, hydroxylase DUF4448 PF14610.6 KOS19130.1 - 1.8e-33 115.9 0.0 2.4e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF4045 PF13254.6 KOS19131.1 - 0.27 10.8 8.8 0.48 10.0 8.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DUF3716 PF12511.8 KOS19132.1 - 4.6e-07 29.8 4.9 7.6e-07 29.1 4.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) NAD_binding_1 PF00175.21 KOS19133.1 - 3e-31 108.3 0.0 4.5e-31 107.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOS19133.1 - 1.4e-23 83.1 0.0 2.8e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOS19133.1 - 1.7e-09 38.0 0.0 0.00016 21.8 0.0 2.2 2 0 0 2 2 2 2 Ferric reductase NAD binding domain SH3_1 PF00018.28 KOS19134.1 - 3.4e-09 36.2 0.0 7.9e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS19134.1 - 4.4e-08 32.8 0.1 4.4e-08 32.8 0.1 2.2 3 0 0 3 3 3 1 Variant SH3 domain SH3_2 PF07653.17 KOS19134.1 - 3.3e-05 23.5 0.0 7.9e-05 22.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Ssu72 PF04722.13 KOS19135.1 - 4.1e-85 284.2 0.0 4.7e-85 284.0 0.0 1.0 1 0 0 1 1 1 1 Ssu72-like protein GIT_SHD PF08518.11 KOS19136.1 - 8.8e-25 86.0 3.6 1.2e-13 50.4 1.2 2.7 2 0 0 2 2 2 2 Spa2 homology domain (SHD) of GIT DUF2666 PF10869.8 KOS19136.1 - 0.15 12.3 2.5 0.38 11.0 2.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) Prominin PF05478.11 KOS19136.1 - 0.17 9.8 9.3 0.29 9.0 9.3 1.4 1 0 0 1 1 1 0 Prominin Cor1 PF04803.12 KOS19136.1 - 0.27 11.5 22.5 1 9.6 2.1 2.9 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region YtxH PF12732.7 KOS19136.1 - 2.4 8.8 6.6 1.7e+02 2.8 4.8 4.2 3 1 0 3 3 3 0 YtxH-like protein AAA_13 PF13166.6 KOS19136.1 - 6.4 5.3 17.0 1.6 7.2 7.3 1.8 1 1 1 2 2 2 0 AAA domain DUF2163 PF09931.9 KOS19137.1 - 0.14 12.4 0.0 0.18 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2163) ODV-E18 PF10717.9 KOS19138.1 - 1.1 9.2 5.1 2.2 8.2 5.1 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 CcmE PF03100.15 KOS19138.1 - 2 8.4 4.3 10 6.1 1.4 2.3 2 0 0 2 2 2 0 CcmE GWT1 PF06423.12 KOS19141.1 - 1.9e-42 144.9 2.1 4.5e-42 143.7 1.1 2.1 2 0 0 2 2 2 1 GWT1 DUF4818 PF16089.5 KOS19141.1 - 0.0011 19.5 0.1 0.0011 19.5 0.1 3.5 4 0 0 4 4 4 1 Domain of unknown function (DUF4818) MDM10 PF12519.8 KOS19142.1 - 0.0013 17.7 8.1 0.0013 17.7 8.1 1.7 1 1 1 2 2 2 1 Mitochondrial distribution and morphology protein 10 UreE_C PF05194.12 KOS19142.1 - 2 8.9 21.6 0.29 11.6 7.6 3.1 2 0 0 2 2 2 0 UreE urease accessory protein, C-terminal domain Glyco_tranf_2_3 PF13641.6 KOS19143.1 - 5.5e-25 88.6 0.0 8.2e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KOS19143.1 - 2e-07 30.6 0.0 3.7e-07 29.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOS19143.1 - 4.3e-07 29.9 0.0 9e-07 28.8 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 2 FAD-oxidase_C PF02913.19 KOS19144.1 - 5.5e-64 216.2 0.2 1e-63 215.3 0.2 1.5 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 KOS19144.1 - 1.4e-36 125.2 0.0 2.7e-36 124.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain Clr5 PF14420.6 KOS19145.1 - 1.5e-15 57.1 0.1 3.3e-15 56.0 0.1 1.6 1 0 0 1 1 1 1 Clr5 domain HTH_33 PF13592.6 KOS19145.1 - 0.039 13.6 0.0 0.14 11.8 0.0 2.0 1 1 1 2 2 2 0 Winged helix-turn helix MFS_1 PF07690.16 KOS19146.1 - 2.6e-48 164.7 59.6 1.5e-46 159.0 59.2 2.8 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS19146.1 - 2.1e-24 85.9 26.3 2.5e-24 85.7 25.6 1.4 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOS19146.1 - 4.2e-16 58.8 5.1 4.2e-16 58.8 5.1 3.3 3 1 1 4 4 4 2 Sugar (and other) transporter Pex14_N PF04695.13 KOS19146.1 - 0.00015 22.4 4.6 0.00015 22.4 4.6 2.1 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region RP-C_C PF11800.8 KOS19146.1 - 0.0013 18.9 0.6 0.0027 17.8 0.6 1.5 1 0 0 1 1 1 1 Replication protein C C-terminal region GET2 PF08690.10 KOS19146.1 - 0.009 15.7 0.3 0.016 14.9 0.3 1.3 1 0 0 1 1 1 1 GET complex subunit GET2 BSMAP PF12280.8 KOS19146.1 - 0.012 15.9 0.8 0.022 15.0 0.8 1.4 1 0 0 1 1 1 0 Brain specific membrane anchored protein DUF913 PF06025.12 KOS19146.1 - 0.077 12.0 0.5 0.11 11.4 0.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 KOS19146.1 - 0.086 11.6 3.3 0.14 10.9 3.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Suf PF05843.14 KOS19146.1 - 0.35 10.8 3.7 0.53 10.2 3.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Orf78 PF06024.12 KOS19146.1 - 0.39 11.0 1.1 0.93 9.8 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Roughex PF06020.11 KOS19146.1 - 1.3 8.0 10.8 1.9 7.5 10.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Pneumo_att_G PF05539.11 KOS19146.1 - 2.8 7.4 10.5 6.4 6.3 10.5 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DUF4661 PF15576.6 KOS19146.1 - 5.2 6.9 5.3 8.7 6.2 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) UPF0183 PF03676.14 KOS19147.1 - 1.1e-50 173.1 0.0 1.9e-15 57.1 0.0 4.2 4 0 0 4 4 4 4 Uncharacterised protein family (UPF0183) AAA_23 PF13476.6 KOS19148.1 - 5.9e-34 118.3 0.0 5.9e-34 118.3 0.0 7.9 1 1 3 5 5 3 1 AAA domain AAA_21 PF13304.6 KOS19148.1 - 1.1e-10 41.9 2.0 0.001 18.9 1.8 3.8 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 KOS19148.1 - 4.1e-08 33.3 6.9 4.1e-07 30.1 1.8 6.0 1 1 1 3 3 2 2 AAA ATPase domain SbcCD_C PF13558.6 KOS19148.1 - 9.5e-06 25.8 1.1 2.4e-05 24.5 0.0 2.4 2 0 0 2 2 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 KOS19148.1 - 0.00068 19.1 50.8 0.0067 15.9 50.8 2.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS19148.1 - 0.0029 17.3 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 KOS19148.1 - 0.021 15.2 0.0 0.021 15.2 0.0 5.5 5 2 0 6 6 5 0 AAA ATPase domain ABC_tran PF00005.27 KOS19148.1 - 0.072 13.6 0.2 0.072 13.6 0.2 7.2 3 2 1 5 5 3 0 ABC transporter AAA_22 PF13401.6 KOS19148.1 - 0.15 12.3 0.0 0.15 12.3 0.0 5.4 6 1 0 6 6 6 0 AAA domain Halo_GVPC PF05465.13 KOS19148.1 - 0.67 10.3 7.4 1.4 9.2 0.7 3.8 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat Methyltransf_25 PF13649.6 KOS19148.1 - 1.5 9.6 3.4 14 6.4 0.1 4.1 3 1 1 4 4 3 0 Methyltransferase domain Mce4_CUP1 PF11887.8 KOS19148.1 - 2.6 7.4 6.5 2.5 7.5 0.0 3.2 3 0 0 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative Kinesin PF00225.23 KOS19149.1 - 2.1e-110 368.8 0.9 4.2e-110 367.8 0.9 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOS19149.1 - 6.2e-27 94.4 0.0 2.3e-26 92.5 0.0 2.0 1 0 0 1 1 1 1 Microtubule binding Microtub_bind PF13931.6 KOS19149.1 - 1.2e-05 25.7 0.2 1.2e-05 25.7 0.2 4.8 4 2 2 6 6 6 1 Kinesin-associated microtubule-binding Prominin PF05478.11 KOS19149.1 - 0.00064 17.8 3.3 0.00064 17.8 3.3 3.7 2 1 1 4 4 4 2 Prominin SAM_Exu PF18609.1 KOS19149.1 - 2.8 8.1 5.2 39 4.4 0.0 4.5 4 0 0 4 4 4 0 Exuperantia SAM-like domain Atg14 PF10186.9 KOS19149.1 - 6.5 5.7 28.9 0.42 9.7 5.7 3.1 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_Mu_Gam PF07352.12 KOS19149.1 - 6.8 6.6 20.1 1 9.3 2.7 4.6 2 2 3 5 5 5 0 Bacteriophage Mu Gam like protein Gp-FAR-1 PF05823.12 KOS19149.1 - 8.8 6.7 15.2 2.6 8.4 0.1 4.3 2 1 3 5 5 5 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Asp PF00026.23 KOS19150.1 - 1.1e-33 117.0 0.0 2.3e-33 116.0 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Asp_protease_2 PF13650.6 KOS19150.1 - 4.9e-05 23.9 0.0 1 10.0 0.0 3.2 3 0 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 KOS19150.1 - 0.0013 18.6 0.0 0.14 11.9 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 KOS19150.1 - 0.082 13.5 0.0 18 6.0 0.0 2.9 3 0 0 3 3 3 0 gag-polyprotein putative aspartyl protease TAXi_N PF14543.6 KOS19150.1 - 2.2 8.5 6.8 74 3.5 4.9 3.0 3 1 0 3 3 3 0 Xylanase inhibitor N-terminal Vps39_1 PF10366.9 KOS19151.1 - 1.4e-32 112.2 0.2 1.8e-31 108.6 0.0 3.0 4 0 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 KOS19151.1 - 8.4e-23 80.9 0.0 4.6e-22 78.5 0.0 2.3 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CNH PF00780.22 KOS19151.1 - 1.1e-16 61.2 0.0 4e-16 59.4 0.0 1.8 1 1 0 1 1 1 1 CNH domain Cnd1_N PF12922.7 KOS19151.1 - 0.0055 16.6 0.1 0.0055 16.6 0.1 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Clathrin PF00637.20 KOS19151.1 - 0.014 15.3 1.9 0.072 13.0 0.4 2.6 3 0 0 3 3 3 0 Region in Clathrin and VPS TPR_19 PF14559.6 KOS19151.1 - 0.14 12.7 2.3 9.1 6.9 0.2 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.8 KOS19151.1 - 2.9 7.4 8.4 3.1 7.3 7.0 1.6 2 0 0 2 2 2 0 Spt20 family SPX PF03105.19 KOS19152.1 - 9.7e-40 137.7 0.0 5.8e-27 95.6 0.0 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 KOS19152.1 - 1.4e-33 116.7 40.0 2.1e-33 116.1 40.0 1.3 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 KOS19152.1 - 1.4e-23 83.6 43.5 1.4e-23 83.6 43.5 2.1 1 1 1 2 2 2 2 Citrate transporter RFX_DNA_binding PF02257.15 KOS19152.1 - 0.21 12.2 0.0 0.52 11.0 0.0 1.6 1 0 0 1 1 1 0 RFX DNA-binding domain RINGv PF12906.7 KOS19153.1 - 1.4e-09 37.9 4.5 1.2e-08 35.0 1.7 2.2 2 0 0 2 2 2 1 RING-variant domain PHD_4 PF16866.5 KOS19153.1 - 0.0011 19.0 2.7 0.12 12.4 1.6 2.3 2 0 0 2 2 2 2 PHD-finger zf-MIZ PF02891.20 KOS19153.1 - 0.043 13.6 2.0 0.078 12.7 2.0 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger DUF202 PF02656.15 KOS19153.1 - 0.11 13.0 1.9 0.99 9.9 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) PsbI PF02532.14 KOS19153.1 - 0.28 11.2 4.1 1.2 9.1 4.1 2.1 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) zf-RING_2 PF13639.6 KOS19153.1 - 0.31 11.4 4.0 0.73 10.2 1.0 2.2 2 0 0 2 2 2 0 Ring finger domain MFS_MOT1 PF16983.5 KOS19153.1 - 0.5 10.8 3.7 0.74 10.2 1.9 2.0 1 1 1 2 2 2 0 Molybdate transporter of MFS superfamily PHD PF00628.29 KOS19153.1 - 1.2 9.1 6.5 0.21 11.5 2.3 1.8 2 0 0 2 2 2 0 PHD-finger Glyco_transf_34 PF05637.12 KOS19154.1 - 1.1e-67 228.3 0.0 1.3e-67 228.0 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family DUF273 PF03314.14 KOS19154.1 - 0.00069 19.2 0.0 0.048 13.2 0.0 2.1 1 1 0 1 1 1 1 Protein of unknown function, DUF273 DUF4131 PF13567.6 KOS19154.1 - 0.056 13.1 0.0 0.089 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) Proteasome PF00227.26 KOS19155.1 - 4.3e-55 186.2 0.1 1.6e-32 112.5 0.0 2.2 2 0 0 2 2 2 2 Proteasome subunit Proteasome_A_N PF10584.9 KOS19155.1 - 1.2e-10 40.9 0.3 3.2e-10 39.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Ribonuclease_3 PF00636.26 KOS19156.1 - 1.6e-36 125.1 0.0 3.6e-17 62.9 0.0 3.1 3 0 0 3 3 3 2 Ribonuclease III domain Dicer_dimer PF03368.14 KOS19156.1 - 2.8e-25 88.3 0.1 7.8e-25 86.9 0.1 1.8 1 0 0 1 1 1 1 Dicer dimerisation domain Ribonucleas_3_3 PF14622.6 KOS19156.1 - 1.9e-24 86.2 0.0 4.6e-10 39.8 0.0 3.9 3 1 0 3 3 3 3 Ribonuclease-III-like Helicase_C PF00271.31 KOS19156.1 - 1.8e-16 60.5 0.0 4.2e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS19156.1 - 1.9e-06 27.8 0.0 3.8e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_2 PF06733.15 KOS19156.1 - 0.00097 18.8 0.0 0.0022 17.6 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 KOS19156.1 - 0.0038 17.3 0.0 0.0072 16.3 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PTH2 PF01981.16 KOS19157.1 - 1.4e-48 164.1 0.4 1.8e-48 163.7 0.4 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 CHD5 PF04420.14 KOS19158.1 - 3.9e-61 205.6 1.7 3.9e-61 205.6 1.7 1.7 2 0 0 2 2 2 1 CHD5-like protein DUF4834 PF16118.5 KOS19158.1 - 0.1 13.6 1.1 0.74 10.8 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) RIBIOP_C PF04950.12 KOS19159.1 - 3.6e-107 358.1 0.0 6.3e-107 357.3 0.0 1.4 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 KOS19159.1 - 1.9e-17 63.1 0.0 4.6e-17 61.9 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain BAF1_ABF1 PF04684.13 KOS19160.1 - 0.25 10.4 30.8 0.28 10.2 30.8 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor WD40 PF00400.32 KOS19161.1 - 2e-12 47.4 5.7 0.0016 19.2 0.1 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19161.1 - 5.4e-10 39.4 1.8 0.00069 19.9 0.0 4.5 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS19161.1 - 5e-05 23.3 0.2 0.36 10.7 0.0 3.3 3 0 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 KOS19161.1 - 0.12 11.9 0.5 0.41 10.2 0.2 2.1 1 1 1 2 2 2 0 PQQ-like domain DUF1708 PF08101.11 KOS19162.1 - 1.6e-165 551.5 0.0 2.3e-165 550.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) SUIM_assoc PF16619.5 KOS19162.1 - 0.022 14.8 7.9 0.097 12.7 4.4 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF726 PF05277.12 KOS19163.1 - 3.2e-112 374.8 0.2 3.9e-112 374.6 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) PE-PPE PF08237.11 KOS19163.1 - 0.0083 15.7 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 PE-PPE domain Thioesterase PF00975.20 KOS19163.1 - 0.092 12.8 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Cutinase PF01083.22 KOS19163.1 - 0.11 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Cutinase Sel1 PF08238.12 KOS19164.1 - 3.9e-40 135.4 37.7 4.5e-06 27.1 0.0 12.2 12 0 0 12 12 12 8 Sel1 repeat SNAP PF14938.6 KOS19164.1 - 0.49 9.8 5.4 3.5 7.0 0.1 2.9 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP LapA_dom PF06305.11 KOS19164.1 - 0.89 9.4 2.6 2.1 8.2 2.6 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TPR_8 PF13181.6 KOS19164.1 - 2.1 8.8 6.8 26 5.3 0.0 6.2 8 2 3 11 11 11 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOS19164.1 - 6.3 7.7 27.4 22 6.0 0.1 8.9 10 0 0 10 10 10 0 Tetratricopeptide repeat CcmD PF04995.14 KOS19164.1 - 9.9 6.3 8.8 4 7.6 5.2 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) UDG PF03167.19 KOS19165.1 - 2.3e-21 76.4 0.0 4.2e-21 75.5 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily BSP_II PF05432.11 KOS19165.1 - 2.3 7.8 19.8 3.4 7.3 19.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) tRNA-synt_2c PF01411.19 KOS19166.1 - 2.8e-215 716.0 0.7 4.7e-215 715.3 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 KOS19166.1 - 5.6e-17 61.6 0.1 1.6e-16 60.1 0.1 1.9 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 KOS19166.1 - 3.4e-11 43.7 1.6 1.3e-10 41.8 1.6 2.1 1 0 0 1 1 1 1 DHHA1 domain LprI PF07007.12 KOS19166.1 - 3.9 8.2 4.7 4.2 8.1 0.3 2.7 3 0 0 3 3 3 0 Lysozyme inhibitor LprI Ribosomal_60s PF00428.19 KOS19167.1 - 0.07 13.7 6.4 1.7 9.3 0.5 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cwf_Cwc_15 PF04889.12 KOS19167.1 - 2 8.1 7.7 0.29 10.8 2.2 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 KOS19167.1 - 2.3 7.5 5.1 3.5 6.9 5.1 1.3 1 0 0 1 1 1 0 NOA36 protein PALP PF00291.25 KOS19168.1 - 1.8e-58 198.3 3.2 2.3e-58 197.9 3.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Methyltransf_28 PF02636.17 KOS19169.1 - 1.3e-37 129.9 0.0 2.4e-37 129.0 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 KOS19169.1 - 0.0052 16.7 0.0 0.015 15.1 0.0 1.7 2 0 0 2 2 2 1 PRMT5 arginine-N-methyltransferase LSM PF01423.22 KOS19171.1 - 3.4e-14 52.3 0.0 4.4e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 LSM domain IU_nuc_hydro PF01156.19 KOS19172.1 - 8.9e-61 206.1 0.0 1.5e-60 205.3 0.0 1.3 1 1 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF2183 PF09949.9 KOS19173.1 - 4e-32 110.5 0.0 8.8e-32 109.4 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 KOS19173.1 - 0.065 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) WD40 PF00400.32 KOS19174.1 - 7.1e-44 146.9 17.9 3.8e-08 33.9 0.2 8.6 8 0 0 8 8 8 7 WD domain, G-beta repeat F-box-like PF12937.7 KOS19174.1 - 2.6e-12 46.4 1.3 6.2e-12 45.2 1.3 1.7 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 KOS19174.1 - 2.2e-10 40.7 0.8 0.0023 18.2 0.0 5.8 2 2 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain F-box PF00646.33 KOS19174.1 - 8e-10 38.4 0.4 2.1e-09 37.0 0.4 1.8 1 0 0 1 1 1 1 F-box domain Nup160 PF11715.8 KOS19174.1 - 1.7e-08 33.6 6.9 0.36 9.4 0.2 4.2 2 1 2 4 4 4 4 Nucleoporin Nup120/160 F-box_4 PF15966.5 KOS19174.1 - 0.0005 19.9 0.0 0.0013 18.6 0.0 1.7 1 0 0 1 1 1 1 F-box WD40_like PF17005.5 KOS19174.1 - 0.0037 16.6 0.0 0.025 13.9 0.3 2.0 2 0 0 2 2 2 1 WD40-like domain PALB2_WD40 PF16756.5 KOS19174.1 - 0.09 11.7 2.1 9.6 5.0 0.1 3.3 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Dynactin_p62 PF05502.13 KOS19175.1 - 2.4e-198 659.7 0.0 4.6e-198 658.8 0.0 1.4 1 1 0 1 1 1 1 Dynactin p62 family Mito_carr PF00153.27 KOS19179.1 - 3.6e-64 212.7 0.1 1.2e-20 73.2 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein PsbH PF00737.20 KOS19179.1 - 0.15 11.8 0.2 0.35 10.6 0.2 1.6 1 0 0 1 1 1 0 Photosystem II 10 kDa phosphoprotein WSC PF01822.19 KOS19180.1 - 0.043 14.0 4.7 0.093 12.9 4.7 1.7 1 0 0 1 1 1 0 WSC domain Ribosomal_S7e PF01251.18 KOS19181.1 - 1.9e-82 275.5 0.3 2.2e-82 275.3 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Thioredoxin PF00085.20 KOS19182.1 - 1.3e-54 182.5 0.0 4.5e-28 97.3 0.0 2.3 2 0 0 2 2 2 2 Thioredoxin ERp29 PF07749.12 KOS19182.1 - 3.8e-24 85.4 0.3 1.2e-23 83.8 0.0 2.0 3 0 0 3 3 2 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_2 PF13098.6 KOS19182.1 - 1.5e-14 54.3 0.0 1.6e-07 31.7 0.0 3.0 2 2 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 KOS19182.1 - 1.1e-12 47.9 0.0 1.2e-06 28.1 0.0 2.1 1 1 1 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 KOS19182.1 - 1.7e-09 37.6 0.0 0.0011 18.9 0.0 2.4 2 0 0 2 2 2 2 AhpC/TSA family Thioredoxin_8 PF13905.6 KOS19182.1 - 1.2e-08 35.2 0.0 0.0023 18.2 0.0 2.9 2 1 0 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 KOS19182.1 - 4e-08 33.1 0.0 0.001 18.8 0.0 2.3 2 0 0 2 2 2 2 Redoxin Thioredoxin_7 PF13899.6 KOS19182.1 - 7.3e-07 29.3 0.0 0.042 14.0 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like TraF PF13728.6 KOS19182.1 - 4.5e-06 26.7 0.0 0.061 13.1 0.0 2.2 2 0 0 2 2 2 2 F plasmid transfer operon protein ERp29_N PF07912.13 KOS19182.1 - 9.1e-05 22.6 0.0 0.0026 17.9 0.0 2.3 2 0 0 2 2 2 1 ERp29, N-terminal domain HyaE PF07449.11 KOS19182.1 - 0.00012 22.0 0.0 0.015 15.2 0.0 2.6 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE Glutaredoxin PF00462.24 KOS19182.1 - 0.0003 21.0 0.1 0.55 10.5 0.0 2.8 2 1 0 2 2 2 2 Glutaredoxin Thioredoxin_9 PF14595.6 KOS19182.1 - 0.00096 18.9 0.0 0.46 10.3 0.0 2.5 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_4 PF13462.6 KOS19182.1 - 0.0065 16.6 1.6 18 5.5 0.1 4.1 3 2 2 5 5 5 0 Thioredoxin Ribosomal_S14 PF00253.21 KOS19183.1 - 4.3e-14 52.0 2.2 5.5e-14 51.7 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e ZZ PF00569.17 KOS19183.1 - 0.28 11.0 4.2 2.6 7.9 4.2 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type zf-rbx1 PF12678.7 KOS19185.1 - 6.8e-10 39.1 1.1 6.8e-10 39.1 1.1 1.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 KOS19185.1 - 3.7e-07 30.4 7.6 2e-06 28.0 7.6 2.2 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 KOS19185.1 - 2.6e-06 27.3 0.9 5.9e-06 26.1 0.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOS19185.1 - 4e-06 26.6 1.0 4e-06 26.6 1.0 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS19185.1 - 4.5e-06 26.6 0.4 7.7e-05 22.6 0.0 2.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOS19185.1 - 3.1e-05 23.7 1.7 3.1e-05 23.7 1.7 2.6 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOS19185.1 - 0.00014 21.6 2.5 0.00034 20.4 2.5 1.7 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 KOS19185.1 - 0.0013 18.5 1.3 0.0013 18.5 1.3 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOS19185.1 - 0.0052 16.8 1.3 0.024 14.7 0.5 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 KOS19185.1 - 0.0059 16.2 1.0 0.0059 16.2 1.0 2.0 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 KOS19185.1 - 0.012 15.3 0.6 0.012 15.3 0.6 3.2 3 0 0 3 3 3 0 RING-like zinc finger VIT1 PF01988.19 KOS19185.1 - 0.04 13.8 0.1 0.04 13.8 0.1 1.6 2 0 0 2 2 2 0 VIT family zf-C3H2C3 PF17122.5 KOS19185.1 - 0.3 11.2 3.2 2.5 8.2 1.4 2.5 2 0 0 2 2 2 0 Zinc-finger DNA_pol_B PF00136.21 KOS19186.1 - 2.5e-149 497.9 0.5 3.3e-149 497.5 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 KOS19186.1 - 2.1e-80 270.4 0.0 4.5e-80 269.3 0.0 1.6 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Rhomboid PF01694.22 KOS19186.1 - 8.6e-32 110.2 6.6 8.6e-32 110.2 6.6 1.8 2 0 0 2 2 2 1 Rhomboid family zf-C4pol PF14260.6 KOS19186.1 - 3e-17 62.8 5.3 8.4e-17 61.4 5.3 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta RNase_H_2 PF13482.6 KOS19186.1 - 0.027 14.5 0.1 0.15 12.0 0.1 2.2 1 1 0 1 1 1 0 RNase_H superfamily DUF2614 PF11023.8 KOS19186.1 - 0.056 13.5 0.0 0.056 13.5 0.0 2.7 4 0 0 4 4 4 0 Zinc-ribbon containing domain DUF2508 PF10704.9 KOS19186.1 - 0.084 13.1 0.3 0.63 10.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) DNA_pol_B_2 PF03175.13 KOS19186.1 - 0.12 11.3 0.4 7.2 5.3 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral DUF2177 PF09945.9 KOS19186.1 - 0.18 11.9 3.5 11 6.1 1.1 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2177) SUIM_assoc PF16619.5 KOS19186.1 - 1 9.5 7.0 2.6 8.2 7.0 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 C1_1 PF00130.22 KOS19186.1 - 5.4 7.0 15.0 1.6 8.7 0.5 3.4 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF3915 PF13054.6 KOS19187.1 - 0.74 9.8 4.9 3.2 7.8 4.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) DUF4646 PF15496.6 KOS19188.1 - 0.005 17.4 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4646) ELFV_dehydrog PF00208.21 KOS19189.1 - 1.3e-83 280.4 0.3 1.7e-83 280.1 0.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 KOS19189.1 - 7.8e-49 164.9 0.0 1.3e-48 164.1 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NAD_binding_7 PF13241.6 KOS19189.1 - 0.0033 17.8 0.0 0.0085 16.5 0.0 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding WD40 PF00400.32 KOS19190.1 - 4.1e-17 62.2 23.4 3.5e-06 27.7 0.4 7.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19190.1 - 2.6e-09 37.2 0.5 0.11 12.8 0.0 5.7 1 1 4 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 KOS19190.1 - 0.012 15.7 0.0 0.17 12.0 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF4221 PF13970.6 KOS19190.1 - 0.063 12.8 0.0 2.7 7.5 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Dynamin_M PF01031.20 KOS19191.1 - 4.3e-101 337.9 0.1 8.3e-101 337.0 0.0 1.5 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 KOS19191.1 - 6.7e-56 188.9 0.0 1.2e-55 188.1 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOS19191.1 - 7.1e-30 103.0 4.6 7.1e-30 103.0 4.6 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOS19191.1 - 8e-06 25.9 0.2 8.3e-05 22.6 0.2 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 KOS19191.1 - 0.051 13.3 0.5 2.4 7.8 0.1 2.3 2 0 0 2 2 2 0 AAA ATPase domain FeoB_N PF02421.18 KOS19191.1 - 0.076 12.5 0.1 7.5 6.1 0.1 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B SpoIIE PF07228.12 KOS19192.1 - 1.9e-07 31.2 0.0 1.1e-06 28.7 0.0 1.9 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOS19192.1 - 1e-05 25.3 0.0 2e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C PP2C PF00481.21 KOS19192.1 - 0.0032 17.1 0.1 0.36 10.4 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C EMC3_TMCO1 PF01956.16 KOS19193.1 - 3.7e-53 179.8 2.9 5.5e-53 179.2 2.9 1.3 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like RNA_pol_Rbc25 PF08292.12 KOS19194.1 - 8.3e-32 110.1 2.3 1.4e-30 106.1 2.3 2.1 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 KOS19194.1 - 1.3e-13 51.1 0.0 2.1e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 DNA_pol_B PF00136.21 KOS19195.1 - 1.1e-113 380.4 0.1 1.7e-113 379.8 0.1 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 KOS19195.1 - 9.7e-69 230.8 0.4 2.1e-68 229.7 0.4 1.6 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 KOS19195.1 - 7.1e-41 140.4 0.0 1.1e-40 139.8 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 KOS19195.1 - 3.2e-24 84.8 9.4 3.2e-24 84.8 9.4 3.3 3 0 0 3 3 3 1 DNA polymerase alpha subunit p180 N terminal DNA_pol_B_2 PF03175.13 KOS19195.1 - 0.0016 17.4 0.3 0.025 13.5 0.0 2.4 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral PreAtp-grasp PF18604.1 KOS19195.1 - 0.09 12.4 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Pre ATP-grasp domain NUFIP1 PF10453.9 KOS19196.1 - 1.5e-08 34.4 0.8 1.5e-08 34.4 0.8 2.4 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) zf_CCCH_4 PF18345.1 KOS19196.1 - 0.018 15.1 6.8 0.032 14.3 6.8 1.4 1 0 0 1 1 1 0 Zinc finger domain zf-CCCH PF00642.24 KOS19196.1 - 0.082 12.8 5.8 0.14 12.1 5.8 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) SPC25 PF06703.11 KOS19197.1 - 1.8e-50 170.9 0.0 2.2e-50 170.6 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) WD40 PF00400.32 KOS19198.1 - 2.1e-09 37.9 7.7 0.04 14.8 0.1 5.9 5 0 0 5 5 5 3 WD domain, G-beta repeat RNA_pol_N PF01194.17 KOS19199.1 - 2.1e-29 101.6 1.0 2.6e-29 101.3 1.0 1.1 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 KOS19199.1 - 0.022 15.0 0.2 0.034 14.4 0.2 1.3 1 1 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) RRM_1 PF00076.22 KOS19200.1 - 2.6e-43 145.7 0.1 6.4e-16 57.9 0.0 3.7 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOS19200.1 - 0.00046 20.2 0.1 4.6 7.4 0.0 3.9 3 0 0 3 3 3 2 Limkain b1 RRM_Rrp7 PF17799.1 KOS19200.1 - 0.0063 16.3 0.1 10 5.9 0.0 3.5 3 0 0 3 3 3 1 Rrp7 RRM-like N-terminal domain RRM_3 PF08777.11 KOS19200.1 - 0.013 15.6 0.5 2.1 8.4 0.0 3.2 2 1 2 4 4 4 0 RNA binding motif RRM_occluded PF16842.5 KOS19200.1 - 0.047 13.6 0.0 1.5 8.7 0.0 3.0 3 0 0 3 3 3 0 Occluded RNA-recognition motif TEA PF01285.18 KOS19201.1 - 1e-26 92.8 0.0 2.2e-26 91.7 0.0 1.6 1 0 0 1 1 1 1 TEA/ATTS domain DUF3504 PF12012.8 KOS19201.1 - 0.13 12.1 1.3 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) Ribosomal_60s PF00428.19 KOS19201.1 - 3.1 8.4 15.3 5.3 7.7 3.2 3.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein SelP_N PF04592.14 KOS19202.1 - 0.027 13.9 9.7 0.046 13.1 9.7 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PI3K_1B_p101 PF10486.9 KOS19202.1 - 0.077 10.8 1.4 0.096 10.4 1.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2796 PF10986.8 KOS19202.1 - 0.11 12.4 12.5 0.2 11.6 12.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Zip PF02535.22 KOS19202.1 - 0.14 11.4 2.1 0.21 10.8 2.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Ecl1 PF12855.7 KOS19202.1 - 1.1 10.4 15.6 2.4 9.3 15.6 1.7 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins NOA36 PF06524.12 KOS19202.1 - 1.4 8.1 7.4 2.1 7.6 7.4 1.2 1 0 0 1 1 1 0 NOA36 protein fn3 PF00041.21 KOS19203.1 - 3.8e-10 40.0 0.1 1.3e-09 38.2 0.1 1.9 1 0 0 1 1 1 1 Fibronectin type III domain CENP-B_dimeris PF09026.10 KOS19204.1 - 0.075 13.4 13.1 0.24 11.8 13.1 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 KOS19204.1 - 1.1 9.3 5.8 3.4 7.7 5.8 1.8 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.6 KOS19204.1 - 1.4 9.2 7.9 4.2 7.7 7.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 KOS19204.1 - 1.8 6.6 10.9 3.5 5.6 10.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 KOS19204.1 - 2.2 6.7 4.8 3.6 6.0 4.8 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 KIND PF16474.5 KOS19204.1 - 2.5 8.0 7.6 1.8 8.4 0.2 2.6 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain CDC45 PF02724.14 KOS19204.1 - 3.8 5.7 7.7 0.52 8.5 3.1 1.7 2 0 0 2 2 2 0 CDC45-like protein NOA36 PF06524.12 KOS19204.1 - 4.4 6.5 12.4 8.3 5.6 12.4 1.4 1 0 0 1 1 1 0 NOA36 protein GCIP PF13324.6 KOS19204.1 - 4.6 6.8 9.4 4.6 6.8 7.8 1.8 1 1 1 2 2 2 0 Grap2 and cyclin-D-interacting FSA_C PF10479.9 KOS19205.1 - 1.1 7.4 16.1 2.2 6.3 16.1 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Dynein_light PF01221.18 KOS19206.1 - 1.1e-29 102.6 3.7 2.5e-29 101.4 3.7 1.6 1 1 0 1 1 1 1 Dynein light chain type 1 Imm48 PF15574.6 KOS19206.1 - 0.028 14.2 0.1 0.11 12.3 0.0 1.6 1 1 1 2 2 2 0 Immunity protein 48 SGTA_dimer PF16546.5 KOS19206.1 - 0.096 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Homodimerisation domain of SGTA RRM_1 PF00076.22 KOS19207.1 - 4.4e-11 42.4 0.0 5.2e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS19207.1 - 9.4e-05 22.2 0.0 0.0001 22.1 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KOS19207.1 - 0.011 15.9 0.0 0.014 15.5 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif Smg4_UPF3 PF03467.15 KOS19207.1 - 0.019 15.0 0.0 0.021 14.8 0.0 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family Nup35_RRM_2 PF14605.6 KOS19207.1 - 0.037 14.0 0.0 0.061 13.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF2347 PF09804.9 KOS19208.1 - 4.2e-90 302.2 0.0 2.1e-89 299.9 0.0 1.8 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) DUF4484 PF14831.6 KOS19208.1 - 8.2e-61 205.7 0.0 1.7e-60 204.7 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4484) SPA PF08616.10 KOS19208.1 - 0.011 15.7 0.0 0.05 13.6 0.0 1.9 1 1 0 1 1 1 0 Stabilization of polarity axis Acyltransferase PF01553.21 KOS19209.1 - 8.2e-32 109.6 0.0 1.3e-31 109.0 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acetyltransf_7 PF13508.7 KOS19210.1 - 0.00032 21.1 0.0 0.00058 20.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS19210.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 KOS19210.1 - 0.038 14.1 0.0 0.14 12.2 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PARM PF17061.5 KOS19210.1 - 2.5 8.2 10.4 0.33 11.0 4.2 2.0 2 0 0 2 2 2 0 PARM Mtc PF03820.17 KOS19211.1 - 2e-113 378.5 0.0 2.5e-113 378.3 0.0 1.1 1 0 0 1 1 1 1 Tricarboxylate carrier DUF4045 PF13254.6 KOS19212.1 - 2.8e-76 257.8 40.7 7.3e-44 151.1 25.2 5.9 3 3 3 6 6 6 2 Domain of unknown function (DUF4045) Gelsolin PF00626.22 KOS19212.1 - 4.1e-09 36.2 0.2 0.0016 18.3 0.0 3.7 3 0 0 3 3 3 3 Gelsolin repeat Arf PF00025.21 KOS19213.1 - 1e-53 181.3 0.9 1.7e-53 180.6 0.9 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS19213.1 - 0.00012 22.1 0.1 0.014 15.5 0.1 2.2 1 1 1 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 KOS19213.1 - 0.00039 19.7 0.6 0.0028 16.9 0.1 2.1 1 1 0 2 2 2 1 G-protein alpha subunit Roc PF08477.13 KOS19213.1 - 0.00055 20.1 0.1 0.019 15.2 0.1 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOS19213.1 - 0.00077 18.9 0.1 0.026 14.0 0.1 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOS19213.1 - 0.0016 17.8 0.2 0.58 9.5 0.0 2.1 1 1 1 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOS19213.1 - 0.022 14.3 0.0 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 KOS19213.1 - 0.089 12.7 0.9 0.67 9.8 0.0 2.0 1 1 0 2 2 2 0 NACHT domain PIH1 PF08190.12 KOS19213.1 - 0.15 11.6 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 PIH1 N-terminal domain 6PF2K PF01591.18 KOS19213.1 - 0.17 11.1 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AMP-binding PF00501.28 KOS19214.1 - 4.5e-69 233.1 0.0 5.8e-39 133.9 0.0 3.9 2 2 0 2 2 2 2 AMP-binding enzyme DMAP_binding PF06464.11 KOS19214.1 - 1e-09 39.2 0.0 2.7e-09 37.8 0.0 1.7 1 0 0 1 1 1 1 DMAP1-binding Domain GvpG PF05120.12 KOS19214.1 - 0.0011 18.9 0.3 0.0023 17.9 0.3 1.4 1 0 0 1 1 1 1 Gas vesicle protein G Pkinase PF00069.25 KOS19216.1 - 9.6e-50 169.4 0.0 3.6e-49 167.5 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19216.1 - 3.4e-18 65.9 0.0 2.4e-17 63.1 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 KOS19216.1 - 0.069 12.1 0.2 0.1 11.5 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase DUF3701 PF12482.8 KOS19217.1 - 0.018 15.1 0.6 0.048 13.7 0.2 1.9 2 0 0 2 2 2 0 Phage integrase protein HEAT_2 PF13646.6 KOS19218.1 - 1.5e-13 51.0 0.2 0.014 15.8 0.0 6.4 6 0 0 6 6 6 4 HEAT repeats Vac14_Fab1_bd PF12755.7 KOS19218.1 - 4.4e-08 33.6 0.1 0.035 14.7 0.0 4.2 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 KOS19218.1 - 7.4e-08 32.6 0.0 0.064 13.3 0.0 5.4 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOS19218.1 - 3.3e-05 23.8 18.9 0.73 10.2 0.0 8.9 11 0 0 11 11 11 3 HEAT repeat UME PF08064.13 KOS19218.1 - 0.0007 19.5 1.7 1.3 8.9 0.1 4.5 4 0 0 4 4 4 1 UME (NUC010) domain Adaptin_N PF01602.20 KOS19218.1 - 0.00089 17.9 2.4 2.1 6.8 0.0 5.5 6 1 0 7 7 7 1 Adaptin N terminal region CLASP_N PF12348.8 KOS19218.1 - 0.0014 18.3 1.2 2.5 7.6 0.0 4.6 4 0 0 4 4 4 1 CLASP N terminal UNC45-central PF11701.8 KOS19218.1 - 0.15 12.0 0.0 0.15 12.0 0.0 4.0 5 0 0 5 5 5 0 Myosin-binding striated muscle assembly central HEAT_EZ PF13513.6 KOS19218.1 - 0.51 10.9 15.4 6.9 7.3 0.0 7.0 9 0 0 9 9 9 0 HEAT-like repeat Transcrip_reg PF01709.20 KOS19219.1 - 2.7e-56 190.7 0.0 3.3e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Transcriptional regulator Smoothelin PF12510.8 KOS19219.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein zf-CHCC PF10276.9 KOS19220.1 - 1e-13 51.0 0.6 1.5e-13 50.5 0.6 1.3 1 0 0 1 1 1 1 Zinc-finger domain Amidase_5 PF05382.13 KOS19220.1 - 0.053 13.4 0.1 0.072 13.0 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage peptidoglycan hydrolase MPP6 PF10175.9 KOS19221.1 - 4.2e-07 30.5 0.4 0.00012 22.5 0.4 2.2 1 1 0 1 1 1 1 M-phase phosphoprotein 6 SUZ PF12752.7 KOS19221.1 - 1.2 10.0 6.1 2.6 8.9 6.1 1.6 1 1 0 1 1 1 0 SUZ domain Peptidase_M16_M PF16187.5 KOS19222.1 - 2.7e-96 322.2 0.3 5.1e-96 321.2 0.3 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 KOS19222.1 - 4.4e-34 117.6 0.4 8.5e-33 113.4 0.1 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOS19222.1 - 5.9e-29 101.4 0.0 9.2e-16 58.4 0.0 2.6 2 0 0 2 2 2 2 Peptidase M16 inactive domain UCH PF00443.29 KOS19223.1 - 3.1e-68 230.1 0.0 5.1e-68 229.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS19223.1 - 2.1e-10 40.7 0.0 6.9e-05 22.6 0.0 3.0 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 KOS19223.1 - 2.6e-09 37.6 0.0 8.1e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 DUSP domain zf-ribbon_3 PF13248.6 KOS19223.1 - 0.26 10.8 1.1 3.2 7.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Pet100 PF09803.9 KOS19224.1 - 6.1e-17 61.9 0.0 7.5e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Pet100 Spt20 PF12090.8 KOS19225.1 - 0.0082 15.8 9.0 0.0082 15.8 9.0 2.5 3 0 0 3 3 3 1 Spt20 family Crust_neuro_H PF03858.13 KOS19225.1 - 0.067 14.0 0.3 0.24 12.3 0.3 2.0 1 0 0 1 1 1 0 Crustacean neurohormone H CAML PF14963.6 KOS19225.1 - 0.18 11.9 1.5 0.67 10.0 1.5 2.0 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Oxysterol_BP PF01237.18 KOS19225.1 - 0.3 9.9 3.5 0.49 9.2 0.0 2.1 2 0 0 2 2 2 0 Oxysterol-binding protein RskA PF10099.9 KOS19225.1 - 2.5 8.4 26.0 2.8 8.2 12.2 3.7 3 1 0 3 3 3 0 Anti-sigma-K factor rskA TERB2 PF15101.6 KOS19225.1 - 8.4 6.4 10.3 12 5.9 6.0 2.5 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4834 PF16118.5 KOS19225.1 - 9.3 7.3 7.9 0.46 11.5 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Cwf_Cwc_15 PF04889.12 KOS19225.1 - 9.4 5.9 32.8 1.5 8.5 11.9 3.2 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein NUDIX_2 PF13869.6 KOS19226.1 - 1.7e-79 265.8 0.0 2e-79 265.5 0.0 1.0 1 0 0 1 1 1 1 Nucleotide hydrolase UPF0047 PF01894.17 KOS19227.1 - 3.6e-37 127.0 0.0 4.5e-37 126.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 NAD_kinase PF01513.21 KOS19229.1 - 7.6e-72 242.0 0.0 1.2e-71 241.3 0.0 1.2 1 0 0 1 1 1 1 ATP-NAD kinase Serglycin PF04360.12 KOS19229.1 - 0.018 15.0 1.6 0.018 15.0 1.6 1.9 2 0 0 2 2 2 0 Serglycin DAGK_cat PF00781.24 KOS19229.1 - 0.052 13.2 0.0 0.32 10.6 0.0 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Suf PF05843.14 KOS19229.1 - 0.3 11.0 10.7 0.52 10.3 10.7 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Pex14_N PF04695.13 KOS19229.1 - 0.84 10.3 9.6 2.1 9.0 9.6 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EBP PF05241.12 KOS19230.1 - 6.2e-66 221.2 2.6 7.1e-66 221.0 2.6 1.0 1 0 0 1 1 1 1 Emopamil binding protein Grg1 PF11034.8 KOS19231.1 - 7.9e-28 96.5 12.0 8.7e-28 96.4 12.0 1.0 1 0 0 1 1 1 1 Glucose-repressible protein Grg1 PAP2 PF01569.21 KOS19232.1 - 3.2e-12 46.4 5.7 3.2e-12 46.4 5.7 2.4 2 1 0 2 2 2 1 PAP2 superfamily DUF212 PF02681.14 KOS19232.1 - 0.023 14.8 0.0 0.5 10.5 0.0 2.3 2 0 0 2 2 2 0 Divergent PAP2 family ENOD93 PF03386.14 KOS19232.1 - 0.19 11.7 2.9 0.39 10.6 2.9 1.4 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein TraL PF07178.11 KOS19232.1 - 4.9 7.7 6.5 1.8 9.1 0.4 3.0 1 1 3 4 4 4 0 TraL protein IBR PF01485.21 KOS19233.1 - 5.8e-19 68.1 38.1 2.1e-13 50.2 6.9 4.3 3 2 1 4 4 4 3 IBR domain, a half RING-finger domain RWD PF05773.22 KOS19233.1 - 1.2e-13 51.3 0.0 2.8e-13 50.2 0.0 1.6 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 KOS19233.1 - 0.00041 20.6 7.8 0.00041 20.6 7.8 4.1 3 1 1 4 4 4 2 Ring finger domain zf-RING_UBOX PF13445.6 KOS19233.1 - 0.00046 20.2 6.1 0.00046 20.2 6.1 3.8 3 0 0 3 3 3 2 RING-type zinc-finger zf-RING_5 PF14634.6 KOS19233.1 - 0.0045 16.9 7.8 0.0045 16.9 7.8 4.0 2 1 1 3 3 3 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOS19233.1 - 0.0051 17.0 2.0 0.0051 17.0 2.0 4.1 4 0 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KOS19233.1 - 0.0068 16.1 7.5 0.0068 16.1 7.5 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 KOS19233.1 - 3.1 7.8 38.2 0.038 13.9 8.2 4.2 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) NDT80_PhoG PF05224.12 KOS19234.1 - 1.9e-32 113.0 0.0 3e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family DUF2011 PF09428.10 KOS19235.1 - 1.4e-21 76.5 0.0 3.4e-21 75.3 0.0 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Tho2 PF11262.8 KOS19235.1 - 1.2 8.3 4.9 1.6 7.9 4.9 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3402 PF11882.8 KOS19236.1 - 9.4e-168 559.1 40.9 1.3e-152 509.1 4.7 3.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) N1221 PF07923.13 KOS19236.1 - 3.1e-94 315.4 0.1 6.3e-94 314.4 0.1 1.5 1 0 0 1 1 1 1 N1221-like protein Hamartin PF04388.12 KOS19236.1 - 0.0062 15.3 10.5 0.012 14.3 10.5 1.4 1 0 0 1 1 1 1 Hamartin protein SOG2 PF10428.9 KOS19236.1 - 0.031 13.5 24.0 0.016 14.4 21.8 1.5 2 0 0 2 2 2 0 RAM signalling pathway protein AF-4 PF05110.13 KOS19236.1 - 0.38 8.8 31.9 0.76 7.8 31.9 1.4 1 0 0 1 1 1 0 AF-4 proto-oncoprotein BUD22 PF09073.10 KOS19236.1 - 0.99 8.7 40.9 0.2 11.0 9.6 2.4 2 0 0 2 2 2 0 BUD22 MARVEL PF01284.23 KOS19237.1 - 0.0036 17.4 16.7 0.006 16.6 16.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain RCR PF12273.8 KOS19237.1 - 4.3 8.0 5.1 1.2 9.9 0.1 2.5 3 1 0 3 3 3 0 Chitin synthesis regulation, resistance to Congo red BING4CT PF08149.11 KOS19238.1 - 3e-40 135.9 0.0 7.3e-36 121.8 0.0 3.6 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 KOS19238.1 - 6e-07 29.7 0.1 7.5 6.9 0.0 5.6 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS19238.1 - 2e-06 28.4 0.0 0.16 12.9 0.0 4.8 3 2 1 4 4 4 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 KOS19238.1 - 2.8e-05 23.4 0.1 0.00068 18.8 0.0 2.3 2 0 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 KOS19238.1 - 0.013 14.0 0.1 0.62 8.5 0.0 2.6 3 0 0 3 3 3 0 Cytochrome D1 heme domain MSC PF09402.10 KOS19239.1 - 2e-98 330.0 0.0 3.1e-96 322.8 0.0 2.1 1 1 0 1 1 1 1 Man1-Src1p-C-terminal domain HeH PF12949.7 KOS19239.1 - 5.5e-15 54.8 0.0 1.1e-14 53.8 0.0 1.6 1 0 0 1 1 1 1 HeH/LEM domain Thymopoietin PF08198.11 KOS19239.1 - 0.0068 16.0 0.4 0.018 14.6 0.0 1.8 2 0 0 2 2 2 1 Thymopoietin protein Mt_ATP-synt_B PF05405.14 KOS19240.1 - 1.4e-53 180.9 9.8 1.8e-53 180.5 9.8 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF1539 PF07560.11 KOS19240.1 - 0.064 13.3 0.6 0.13 12.3 0.4 1.6 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) CBF PF03914.17 KOS19241.1 - 2.5e-35 122.0 0.6 9.6e-35 120.1 0.1 2.1 1 1 1 2 2 2 1 CBF/Mak21 family CorA PF01544.18 KOS19242.1 - 9.2e-40 136.8 0.2 2.7e-39 135.3 0.2 1.7 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein RcsF PF16358.5 KOS19242.1 - 0.015 15.3 0.2 0.031 14.3 0.2 1.5 1 0 0 1 1 1 0 RcsF lipoprotein CSTF2_hinge PF14327.6 KOS19243.1 - 4.3e-33 113.6 2.3 4.3e-33 113.6 2.3 2.2 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_1 PF00076.22 KOS19243.1 - 5.9e-22 77.3 0.0 8.9e-22 76.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 KOS19243.1 - 3.4e-11 42.5 3.9 3.4e-11 42.5 3.9 3.1 4 0 0 4 4 4 1 Transcription termination and cleavage factor C-terminal RRM_7 PF16367.5 KOS19243.1 - 0.018 15.1 0.0 0.037 14.1 0.0 1.5 1 1 0 1 1 1 0 RNA recognition motif Spo7_2_N PF15407.6 KOS19243.1 - 0.083 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Sporulation protein family 7 RRM_5 PF13893.6 KOS19243.1 - 0.17 11.5 0.0 0.33 10.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COPIIcoated_ERV PF07970.12 KOS19244.1 - 5e-67 226.0 0.0 7.1e-67 225.5 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOS19244.1 - 3.4e-29 101.0 0.0 5.1e-29 100.5 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Sel1 PF08238.12 KOS19245.1 - 9.7e-13 48.3 4.2 0.00098 19.7 0.1 3.6 3 0 0 3 3 3 3 Sel1 repeat Proteasome PF00227.26 KOS19246.1 - 3.5e-45 153.8 0.0 4.5e-45 153.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 KOS19246.1 - 1.4e-12 46.8 0.1 1.4e-12 46.8 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal NUP214 PF16755.5 KOS19247.1 - 6.9e-05 22.3 0.0 0.00082 18.7 0.1 2.0 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 ANAPC4_WD40 PF12894.7 KOS19247.1 - 8.5e-05 22.8 0.0 0.00069 19.9 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS19247.1 - 0.034 15.0 0.1 0.17 12.8 0.1 2.2 1 0 0 1 1 1 0 WD domain, G-beta repeat USP8_interact PF08941.10 KOS19248.1 - 0.054 13.3 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 USP8 interacting CDH-cyt PF16010.5 KOS19249.1 - 1.3e-13 51.1 0.0 2.3e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 KOS19249.1 - 0.00022 21.4 12.4 0.00022 21.4 12.4 1.8 2 1 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 KOS19249.1 - 0.0067 16.2 7.0 0.0067 16.2 7.0 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF2427) DOMON PF03351.17 KOS19249.1 - 0.013 15.8 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 DOMON domain SdpI PF13630.6 KOS19249.1 - 0.096 12.8 0.5 0.096 12.8 0.5 2.9 2 1 0 2 2 2 0 SdpI/YhfL protein family Serglycin PF04360.12 KOS19249.1 - 1 9.3 7.6 2.7 8.0 0.1 2.3 2 0 0 2 2 2 0 Serglycin AhpC-TSA_2 PF13911.6 KOS19250.1 - 3e-08 33.8 0.0 4.9e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 KOS19250.1 - 0.00023 21.1 0.0 0.00042 20.2 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA family Rtf2 PF04641.12 KOS19250.1 - 0.13 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Tubulin_3 PF14881.6 KOS19251.1 - 4.8e-73 244.7 0.0 3e-72 242.1 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain Misat_Tub_SegII PF10644.9 KOS19251.1 - 2.5e-39 134.2 0.0 7e-39 132.8 0.0 1.7 2 0 0 2 2 2 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 KOS19251.1 - 0.00085 19.6 0.0 0.52 10.5 0.0 2.3 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain CLU PF13236.6 KOS19252.1 - 2.5e-76 256.4 0.0 4.4e-76 255.6 0.0 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 KOS19252.1 - 5e-55 186.2 0.0 1.1e-54 185.2 0.0 1.6 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 TPR_12 PF13424.6 KOS19252.1 - 1.7e-25 89.1 6.4 2.8e-10 40.3 0.1 4.1 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOS19252.1 - 3.7e-22 77.5 0.7 1.3e-06 28.1 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat CLU_N PF15044.6 KOS19252.1 - 2e-21 76.1 0.0 4.3e-21 75.0 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial function, CLU-N-term TPR_8 PF13181.6 KOS19252.1 - 7.3e-06 25.8 5.8 0.0051 16.9 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF727 PF05303.12 KOS19252.1 - 0.0022 18.0 0.0 0.006 16.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF727) TPR_2 PF07719.17 KOS19252.1 - 0.034 14.3 0.2 0.034 14.3 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 KOS19252.1 - 0.3 11.6 4.2 47 4.7 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Nuc_sug_transp PF04142.15 KOS19253.1 - 3.8e-10 39.5 0.6 7.2e-10 38.5 0.6 1.5 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOS19253.1 - 2.7e-08 34.1 28.5 0.00086 19.5 5.6 2.8 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 KOS19253.1 - 8.1e-05 22.1 0.6 8.1e-05 22.1 0.6 2.2 2 0 0 2 2 2 1 Triose-phosphate Transporter family DUF2613 PF11021.8 KOS19253.1 - 0.014 15.5 3.0 2.8 8.1 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Trp_oprn_chp PF09534.10 KOS19253.1 - 0.12 12.1 1.2 0.31 10.8 1.2 1.7 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF423 PF04241.15 KOS19253.1 - 0.68 10.2 6.9 1.6 9.0 1.8 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Wzy_C PF04932.15 KOS19253.1 - 1.7 8.2 19.1 0.048 13.3 4.8 3.3 3 0 0 3 3 3 0 O-Antigen ligase UPF0114 PF03350.16 KOS19253.1 - 8 6.7 13.3 2.3 8.4 0.3 4.4 2 2 3 5 5 5 0 Uncharacterized protein family, UPF0114 PAP_central PF04928.17 KOS19254.1 - 1.1e-110 368.5 0.0 1.5e-110 368.1 0.0 1.1 1 0 0 1 1 1 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 KOS19254.1 - 2.9e-57 193.0 0.7 5e-57 192.3 0.7 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 KOS19254.1 - 2e-09 37.6 0.1 4.5e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 KOS19254.1 - 0.019 15.0 0.0 0.049 13.7 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Peptidase_S49 PF01343.18 KOS19254.1 - 0.036 14.0 0.1 0.08 12.9 0.1 1.5 1 0 0 1 1 1 0 Peptidase family S49 Nrap_D2 PF17403.2 KOS19254.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Forkhead PF00250.18 KOS19255.1 - 1.5e-30 105.3 0.1 3.1e-30 104.2 0.1 1.5 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 KOS19255.1 - 4.6e-10 39.7 0.0 7.8e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOS19255.1 - 9.8e-06 25.8 0.0 1.7e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA_2 PF17913.1 KOS19255.1 - 0.061 13.6 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 FHA domain Ribosomal_L29e PF01779.17 KOS19256.1 - 1.3e-22 79.8 8.6 2.2e-22 79.1 8.6 1.3 1 0 0 1 1 1 1 Ribosomal L29e protein family PAP_assoc PF03828.19 KOS19257.1 - 7.4e-08 32.5 2.0 3.5e-07 30.3 2.0 2.0 1 1 0 1 1 1 1 Cid1 family poly A polymerase Yippee-Mis18 PF03226.14 KOS19258.1 - 7.3e-16 58.3 0.3 8.2e-16 58.1 0.3 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly RIG-I_C-RD PF11648.8 KOS19258.1 - 0.01 16.1 0.6 0.017 15.3 0.6 1.3 1 0 0 1 1 1 0 C-terminal domain of RIG-I HNH_5 PF14279.6 KOS19258.1 - 0.019 14.8 0.4 0.79 9.6 0.0 2.2 2 0 0 2 2 2 0 HNH endonuclease Sen15 PF09631.10 KOS19259.1 - 7.2e-27 93.6 0.0 1.1e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 Sen15 protein An_peroxidase PF03098.15 KOS19260.1 - 4.9e-31 107.9 0.0 1.3e-21 76.8 0.0 3.1 1 1 1 2 2 2 2 Animal haem peroxidase p450 PF00067.22 KOS19260.1 - 0.038 12.7 0.0 0.064 12.0 0.0 1.2 1 0 0 1 1 1 0 Cytochrome P450 WD40 PF00400.32 KOS19261.1 - 9.9e-41 137.0 20.2 3.2e-09 37.2 1.5 7.6 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19261.1 - 1.8e-16 60.2 1.3 0.013 15.7 0.3 6.6 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain PRP4 PF08799.11 KOS19261.1 - 2e-16 59.2 2.3 3.8e-16 58.3 2.3 1.5 1 0 0 1 1 1 1 pre-mRNA processing factor 4 (PRP4) like Ge1_WD40 PF16529.5 KOS19261.1 - 0.0029 16.6 0.0 17 4.2 0.0 4.5 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOS19261.1 - 0.0041 16.5 0.0 0.85 8.9 0.0 3.3 4 0 0 4 4 4 1 WD40-like domain Nbas_N PF15492.6 KOS19261.1 - 0.071 12.4 0.1 3.8 6.8 0.0 2.6 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cyclin_N PF00134.23 KOS19262.1 - 1.5e-10 40.9 0.0 4.7e-10 39.3 0.1 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain Spy1 PF11357.8 KOS19262.1 - 0.086 13.1 0.2 0.15 12.3 0.2 1.3 1 0 0 1 1 1 0 Cell cycle regulatory protein Ndc1_Nup PF09531.10 KOS19262.1 - 0.26 10.0 5.1 0.34 9.5 5.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 KOS19262.1 - 8.1 7.1 23.4 23 5.6 23.4 1.8 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region adh_short PF00106.25 KOS19263.1 - 5.3e-28 97.8 0.3 7.1e-28 97.4 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS19263.1 - 2.1e-25 89.7 0.8 2.5e-25 89.4 0.8 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS19263.1 - 7e-10 39.1 0.4 1.8e-09 37.7 0.2 1.7 2 0 0 2 2 2 1 KR domain GDP_Man_Dehyd PF16363.5 KOS19263.1 - 0.035 13.5 0.0 0.064 12.6 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Iso_dh PF00180.20 KOS19264.1 - 2.5e-124 415.0 0.0 3e-124 414.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PHD PF00628.29 KOS19265.1 - 1.4e-10 40.9 5.4 1.8e-10 40.5 5.4 1.2 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOS19265.1 - 0.0061 16.1 2.3 0.0099 15.4 2.3 1.4 1 0 0 1 1 1 1 PHD-finger C1_1 PF00130.22 KOS19265.1 - 0.032 14.1 1.2 0.056 13.3 1.2 1.5 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Actin PF00022.19 KOS19267.1 - 6.1e-28 97.5 0.0 1.2e-17 63.6 0.0 2.9 2 1 0 2 2 2 2 Actin Actin_micro PF17003.5 KOS19267.1 - 0.00063 19.0 0.9 0.31 10.2 0.1 2.3 2 0 0 2 2 2 2 Putative actin-like family FtsA PF14450.6 KOS19267.1 - 0.0075 16.7 0.0 0.052 14.0 0.0 2.2 2 0 0 2 2 2 1 Cell division protein FtsA MreB_Mbl PF06723.13 KOS19267.1 - 0.045 12.6 0.0 0.83 8.4 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein TFIIA PF03153.13 KOS19267.1 - 2.6 7.9 10.5 4.8 7.1 10.5 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MFS_1 PF07690.16 KOS19268.1 - 3e-20 72.5 28.5 3.2e-12 46.1 6.8 3.1 3 0 0 3 3 3 3 Major Facilitator Superfamily ATG22 PF11700.8 KOS19268.1 - 0.0018 17.0 0.0 0.0018 17.0 0.0 3.1 3 2 2 5 5 5 1 Vacuole effluxer Atg22 like TraL PF07178.11 KOS19268.1 - 0.12 12.8 1.5 9.8 6.7 0.0 3.1 2 0 0 2 2 2 0 TraL protein LacY_symp PF01306.19 KOS19268.1 - 0.44 9.3 5.1 0.089 11.5 0.4 2.0 2 0 0 2 2 2 0 LacY proton/sugar symporter CcmD PF04995.14 KOS19268.1 - 2.2 8.4 9.4 1 9.5 0.9 3.4 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) Sporozoite_P67 PF05642.11 KOS19268.1 - 5.9 4.8 5.1 0.97 7.4 0.9 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Fungal_trans_2 PF11951.8 KOS19269.1 - 2.3e-07 30.0 0.4 3.8e-07 29.2 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Med10 PF09748.9 KOS19270.1 - 2e-52 176.3 0.1 2.3e-52 176.1 0.1 1.0 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex DUF3877 PF12993.7 KOS19270.1 - 0.052 13.4 0.0 0.094 12.6 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) DUF2205 PF10224.9 KOS19270.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Short coiled-coil protein Baculo_PEP_C PF04513.12 KOS19270.1 - 0.2 11.7 0.0 1.3 9.0 0.0 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TPR_1 PF00515.28 KOS19271.1 - 1.1e-30 104.2 9.2 5.9e-06 25.9 0.1 7.4 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOS19271.1 - 4.5e-30 101.3 10.4 0.0005 20.0 0.1 8.2 7 2 1 8 8 8 6 Tetratricopeptide repeat DnaJ PF00226.31 KOS19271.1 - 8.5e-27 93.1 5.3 1.8e-26 92.1 3.4 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_19 PF14559.6 KOS19271.1 - 2.9e-22 78.9 6.3 5.9e-06 26.7 1.0 5.7 3 2 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS19271.1 - 3.5e-20 70.5 6.5 0.00069 19.6 0.1 7.0 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 KOS19271.1 - 3.8e-20 71.3 10.2 2e-05 24.2 0.1 6.5 5 2 1 6 6 6 4 TPR repeat TPR_16 PF13432.6 KOS19271.1 - 3.1e-17 62.9 3.5 0.00022 21.8 0.1 5.4 3 2 0 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 KOS19271.1 - 4e-15 55.9 7.7 6e-05 23.2 0.0 5.7 3 3 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOS19271.1 - 2.7e-13 49.5 5.0 0.008 16.9 0.0 7.6 4 3 3 7 7 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS19271.1 - 7.2e-13 48.6 2.5 9.6e-05 22.5 0.0 4.9 2 2 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 KOS19271.1 - 8.5e-13 47.7 5.6 0.0091 16.3 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOS19271.1 - 3.8e-10 39.1 0.7 0.053 13.6 0.0 6.5 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS19271.1 - 8.9e-10 38.6 1.0 0.051 13.7 0.0 4.7 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOS19271.1 - 8.9e-08 32.3 8.4 0.58 10.9 0.0 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_15 PF13429.6 KOS19271.1 - 2.5e-06 26.9 4.6 0.6 9.3 0.0 4.3 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOS19271.1 - 0.00011 21.9 5.3 5.1 7.1 0.1 5.9 5 1 1 6 6 6 1 Tetratricopeptide repeat BTAD PF03704.17 KOS19271.1 - 0.00082 19.8 1.5 0.67 10.4 0.0 3.9 3 2 0 3 3 3 1 Bacterial transcriptional activator domain TPR_4 PF07721.14 KOS19271.1 - 0.0025 18.3 4.7 5.3 8.0 0.0 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KOS19271.1 - 0.0088 15.5 0.5 2.8 7.3 0.1 3.0 2 1 2 4 4 4 1 Coatomer epsilon subunit DUF2225 PF09986.9 KOS19271.1 - 0.016 15.0 0.3 0.081 12.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) SNAP PF14938.6 KOS19271.1 - 0.027 13.9 5.2 1.2 8.5 0.1 2.6 2 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP RRM_3 PF08777.11 KOS19271.1 - 0.047 13.7 0.7 2 8.5 0.1 2.7 2 0 0 2 2 2 0 RNA binding motif DUF3856 PF12968.7 KOS19271.1 - 0.065 13.3 4.2 17 5.5 0.0 5.2 4 2 0 4 4 3 0 Domain of Unknown Function (DUF3856) SRP_TPR_like PF17004.5 KOS19271.1 - 0.35 10.9 2.9 1.9 8.5 0.2 3.1 3 1 0 4 4 3 0 Putative TPR-like repeat MIT PF04212.18 KOS19271.1 - 0.58 10.3 9.3 9.8 6.3 1.2 3.7 3 2 1 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3560 PF12083.8 KOS19271.1 - 1 9.5 9.3 1.8 8.7 0.3 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3560) zf-FCS PF06467.14 KOS19272.1 - 0.012 15.6 0.4 0.7 9.9 0.0 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-CHY PF05495.12 KOS19272.1 - 0.065 13.7 0.0 0.089 13.3 0.0 1.2 1 0 0 1 1 1 0 CHY zinc finger Stm1_N PF09598.10 KOS19273.1 - 3.2e-14 53.5 2.2 3.2e-14 53.5 2.2 4.1 3 1 0 3 3 3 1 Stm1 HABP4_PAI-RBP1 PF04774.15 KOS19273.1 - 0.014 16.2 11.3 0.014 16.2 11.3 2.5 2 2 1 3 3 3 0 Hyaluronan / mRNA binding family DUF3484 PF11983.8 KOS19273.1 - 0.28 12.3 6.5 3.9 8.7 0.0 2.8 3 0 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch DUF3987 PF13148.6 KOS19273.1 - 1.4 7.9 6.2 2 7.3 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Menin PF05053.13 KOS19273.1 - 7.8 4.7 8.3 10 4.3 8.3 1.1 1 0 0 1 1 1 0 Menin PfkB PF00294.24 KOS19274.1 - 1.9e-68 231.0 0.0 2.2e-68 230.8 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Ribosomal_L2_C PF03947.18 KOS19275.1 - 5.3e-42 143.0 4.9 5.3e-42 143.0 4.9 1.6 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOS19275.1 - 1e-14 54.2 0.1 2.6e-14 53.0 0.1 1.7 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain eRF1_2 PF03464.15 KOS19276.1 - 3.4e-46 156.8 0.1 5.9e-46 156.1 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KOS19276.1 - 4e-40 136.8 0.6 8.3e-40 135.8 0.6 1.6 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 KOS19276.1 - 1.2e-21 77.1 0.0 1.9e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 baeRF_family10 PF18854.1 KOS19276.1 - 5.7e-10 39.6 0.3 1.4e-09 38.3 0.0 1.7 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 10 acVLRF1 PF18859.1 KOS19276.1 - 2.7e-09 37.4 0.0 4.4e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor VASt PF16016.5 KOS19277.1 - 1.4e-32 113.3 0.7 3e-32 112.1 0.7 1.6 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 KOS19277.1 - 7.3e-17 61.9 0.0 1.5e-16 60.9 0.0 1.5 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KOS19277.1 - 3.1e-06 27.6 0.1 1.1e-05 25.9 0.1 2.0 1 0 0 1 1 1 1 PH domain GRAM PF02893.20 KOS19277.1 - 0.0002 21.2 0.0 0.00054 19.8 0.0 1.6 1 0 0 1 1 1 1 GRAM domain BAR PF03114.18 KOS19277.1 - 0.006 16.3 0.1 0.015 15.0 0.1 1.6 1 0 0 1 1 1 1 BAR domain WHIM1 PF15612.6 KOS19278.1 - 0.025 14.1 0.0 0.05 13.2 0.0 1.6 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Nucleo_P87 PF07267.11 KOS19278.1 - 9.3 5.0 8.7 21 3.8 8.7 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1770 PF08589.10 KOS19279.1 - 7.4e-35 119.9 0.0 9.4e-35 119.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1770) Complex1_LYR_2 PF13233.6 KOS19280.1 - 6e-06 26.9 0.0 8.2e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 KOS19280.1 - 8.9e-06 25.7 0.1 1.6e-05 24.8 0.1 1.5 1 0 0 1 1 1 1 Complex 1 protein (LYR family) RNA_pol_L_2 PF13656.6 KOS19281.1 - 2.1e-31 107.5 0.0 2.7e-31 107.1 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 KOS19281.1 - 7.6e-12 44.5 0.0 1e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain zf-C2H2 PF00096.26 KOS19282.1 - 7.5 7.2 10.7 1.8 9.1 1.6 3.2 3 0 0 3 3 3 0 Zinc finger, C2H2 type G10 PF01125.17 KOS19283.1 - 1.6e-55 186.9 0.7 1.9e-55 186.6 0.7 1.0 1 0 0 1 1 1 1 G10 protein POT1PC PF16686.5 KOS19284.1 - 2.1e-23 82.9 0.0 9.5e-12 45.1 0.0 2.4 1 1 1 2 2 2 2 ssDNA-binding domain of telomere protection protein TauD PF02668.16 KOS19285.1 - 1.5e-21 77.4 0.0 1.9e-21 77.1 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 KOS19285.1 - 2.4e-05 24.9 0.0 5e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF971) UCH PF00443.29 KOS19286.1 - 6e-33 114.4 0.0 2.4e-32 112.4 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS19286.1 - 0.00018 21.2 0.0 0.0023 17.6 0.0 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Metallophos PF00149.28 KOS19287.1 - 3.9e-38 132.0 0.1 6.4e-38 131.3 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase adh_short_C2 PF13561.6 KOS19288.1 - 4.6e-52 176.9 6.6 9.5e-52 175.9 6.6 1.4 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS19288.1 - 2.4e-32 112.0 8.4 1.5e-31 109.4 8.4 1.9 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS19288.1 - 2.4e-07 30.8 0.6 2.4e-07 30.8 0.6 1.8 2 0 0 2 2 2 1 KR domain 2-Hacid_dh_C PF02826.19 KOS19288.1 - 0.0059 16.0 0.2 0.015 14.6 0.2 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Epimerase PF01370.21 KOS19288.1 - 0.011 15.2 0.1 0.31 10.4 0.1 2.5 3 0 0 3 3 3 0 NAD dependent epimerase/dehydratase family SBDS_C PF09377.10 KOS19288.1 - 0.091 12.8 0.2 0.12 12.5 0.2 1.3 1 1 0 1 1 1 0 SBDS protein C-terminal domain ApbA PF02558.16 KOS19288.1 - 0.091 12.4 0.2 0.21 11.2 0.2 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 KOS19288.1 - 0.23 11.3 2.7 0.14 12.0 0.8 1.6 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Sulfatase PF00884.23 KOS19289.1 - 9.4e-21 74.5 0.1 1.3e-19 70.7 0.1 2.4 2 1 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 KOS19289.1 - 1.1e-06 28.5 0.0 1.8e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KOS19289.1 - 0.023 13.3 0.0 0.035 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF229) SR-25 PF10500.9 KOS19289.1 - 0.09 12.4 6.9 0.14 11.8 6.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4021 PF13213.6 KOS19289.1 - 0.16 12.0 0.1 0.36 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4021) IMUP PF15761.5 KOS19289.1 - 9.9 6.9 12.8 19 6.0 12.8 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein CBFB_NFYA PF02045.15 KOS19292.1 - 1e-27 96.5 5.2 2e-27 95.6 5.2 1.5 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Hus1 PF04005.12 KOS19292.1 - 0.16 11.0 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 Hus1-like protein Rax2 PF12768.7 KOS19293.1 - 1.7e-74 249.9 0.3 6.6e-73 244.7 0.0 3.2 3 0 0 3 3 3 1 Cortical protein marker for cell polarity LapA_dom PF06305.11 KOS19293.1 - 0.21 11.4 0.4 0.4 10.5 0.4 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain zf-H2C2_2 PF13465.6 KOS19294.1 - 1.8e-10 40.8 13.0 5e-07 29.9 0.4 3.3 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 KOS19294.1 - 2.6e-10 40.2 11.6 2.1e-05 24.7 4.2 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS19294.1 - 3.9e-08 33.5 9.7 0.00016 22.3 2.1 2.8 2 1 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOS19294.1 - 3.4e-06 26.9 6.6 0.00019 21.4 2.6 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 KOS19294.1 - 2.9e-05 24.3 3.3 5e-05 23.5 1.9 2.2 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOS19294.1 - 0.00057 20.1 3.5 0.0012 19.0 1.8 2.3 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 KOS19294.1 - 0.036 14.4 2.5 0.041 14.2 1.3 1.6 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_11 PF16622.5 KOS19294.1 - 0.19 11.5 7.0 3.3 7.5 0.6 2.8 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-BED PF02892.15 KOS19294.1 - 0.45 10.6 5.8 3.7 7.7 5.8 2.2 1 1 0 1 1 1 0 BED zinc finger P34-Arc PF04045.14 KOS19295.1 - 1.7e-105 352.1 0.4 2e-105 351.8 0.4 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc SNase PF00565.17 KOS19296.1 - 2.3e-25 89.2 0.1 3.5e-25 88.6 0.1 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Ribosomal_S13_N PF08069.12 KOS19297.1 - 6.1e-30 103.1 0.5 9.7e-30 102.4 0.5 1.3 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 KOS19297.1 - 3.6e-15 55.9 0.1 6.9e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.18 KOS19297.1 - 0.053 13.4 0.2 0.13 12.1 0.1 1.7 2 0 0 2 2 2 0 'Paired box' domain VRR_NUC PF08774.11 KOS19298.1 - 3.9e-09 36.6 0.0 8.8e-09 35.4 0.0 1.5 1 0 0 1 1 1 1 VRR-NUC domain SF3b1 PF08920.10 KOS19299.1 - 3e-27 95.5 5.5 3e-27 95.5 5.5 2.4 1 1 1 2 2 2 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 KOS19299.1 - 2.6e-12 47.0 7.0 0.1 13.0 0.1 8.0 4 3 2 8 8 8 4 HEAT repeats HEAT_EZ PF13513.6 KOS19299.1 - 8.4e-12 45.3 2.6 0.015 15.8 0.0 7.8 7 1 1 8 8 8 2 HEAT-like repeat HEAT PF02985.22 KOS19299.1 - 3e-10 39.4 7.2 1.3 9.5 0.0 9.2 9 0 0 9 9 9 4 HEAT repeat Cnd1 PF12717.7 KOS19299.1 - 5e-07 29.9 0.8 2.5 8.1 0.0 6.2 5 2 2 7 7 7 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOS19299.1 - 4.2e-05 24.1 0.2 1.2 9.8 0.0 5.5 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region NUC173 PF08161.12 KOS19299.1 - 7.6e-05 22.5 0.3 0.9 9.2 0.0 4.3 4 1 1 5 5 5 2 NUC173 domain DUF3385 PF11865.8 KOS19299.1 - 0.0002 21.3 1.0 0.027 14.4 0.1 4.5 6 0 0 6 6 6 1 Domain of unknown function (DUF3385) Adaptin_N PF01602.20 KOS19299.1 - 0.0002 20.0 0.6 0.13 10.7 0.0 3.5 2 2 1 4 4 4 2 Adaptin N terminal region UME PF08064.13 KOS19299.1 - 0.00031 20.6 0.0 3 7.8 0.0 4.8 4 1 0 5 5 5 1 UME (NUC010) domain UNC45-central PF11701.8 KOS19299.1 - 0.00094 19.2 0.0 0.0032 17.4 0.0 1.9 2 0 0 2 2 1 1 Myosin-binding striated muscle assembly central CLASP_N PF12348.8 KOS19299.1 - 0.0073 15.9 0.1 1.9 8.0 0.0 3.9 4 0 0 4 4 4 1 CLASP N terminal DRIM PF07539.12 KOS19299.1 - 0.016 13.6 0.2 7.4 4.7 0.0 4.0 2 1 2 4 4 4 0 Down-regulated in metastasis MMS19_C PF12460.8 KOS19299.1 - 0.096 11.8 0.0 5.6 6.0 0.0 3.3 3 1 1 4 4 4 0 RNAPII transcription regulator C-terminal RRM_1 PF00076.22 KOS19300.1 - 3.1e-16 59.0 0.0 3.2e-09 36.5 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phlebovirus_NSM PF07246.11 KOS19302.1 - 0.00037 20.0 1.7 0.00055 19.4 1.7 1.2 1 0 0 1 1 1 1 Phlebovirus nonstructural protein NS-M bZIP_2 PF07716.15 KOS19302.1 - 0.15 12.1 14.2 0.25 11.5 14.2 1.3 1 0 0 1 1 1 0 Basic region leucine zipper Peptidase_M18 PF02127.15 KOS19304.1 - 3.6e-173 576.3 0.0 2.6e-172 573.5 0.0 1.9 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 KOS19304.1 - 0.00051 19.1 0.0 0.026 13.6 0.0 2.2 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Aldedh PF00171.22 KOS19309.1 - 1.3e-164 548.2 0.0 1.4e-164 548.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Abhydrolase_7 PF12715.7 KOS19310.1 - 0.22 10.7 0.0 0.4 9.9 0.0 1.3 1 0 0 1 1 1 0 Abhydrolase family p450 PF00067.22 KOS19311.1 - 2.6e-81 273.7 0.0 3.1e-81 273.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ribonuclease PF00545.20 KOS19313.1 - 6e-06 26.9 0.0 8e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 ribonuclease BATS PF06968.13 KOS19314.1 - 2.1e-24 85.4 0.0 1.1e-23 83.1 0.0 2.1 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 KOS19314.1 - 4.3e-16 59.7 0.2 7.3e-16 59.0 0.1 1.4 2 0 0 2 2 2 1 Radical SAM superfamily DegV PF02645.16 KOS19314.1 - 0.11 11.8 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein, DegV family COG1307 MFS_1 PF07690.16 KOS19315.1 - 5.3e-32 111.1 31.0 5.3e-32 111.1 31.0 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS19315.1 - 1e-08 34.5 6.8 1e-08 34.5 6.8 2.5 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KOS19315.1 - 9.3e-06 24.3 6.0 1.4e-05 23.7 5.4 1.6 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4748 PF15932.5 KOS19315.1 - 8 6.3 5.7 1.4 8.7 1.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4748) RGS PF00615.19 KOS19316.1 - 5.6e-06 26.6 0.1 1.1e-05 25.7 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain SET PF00856.28 KOS19317.1 - 4.6e-12 46.6 0.5 3.5e-11 43.8 0.1 2.4 2 1 0 2 2 2 1 SET domain zf-MYND PF01753.18 KOS19317.1 - 0.00032 20.7 13.6 0.00076 19.5 13.6 1.7 1 0 0 1 1 1 1 MYND finger GST_N_3 PF13417.6 KOS19318.1 - 0.00018 21.9 0.0 0.00099 19.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOS19318.1 - 0.0016 18.4 0.0 0.0029 17.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOS19318.1 - 0.0043 17.2 0.0 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOS19318.1 - 0.021 15.1 0.0 0.043 14.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain CMD PF02627.20 KOS19319.1 - 0.036 14.1 0.0 0.084 12.9 0.0 1.6 1 0 0 1 1 1 0 Carboxymuconolactone decarboxylase family DUF2787 PF10980.8 KOS19319.1 - 0.091 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2787) Sugar_tr PF00083.24 KOS19320.1 - 1.9e-70 238.0 10.5 2.2e-70 237.8 10.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS19320.1 - 1.5e-07 30.7 29.1 2.5e-07 30.0 20.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HMG_box PF00505.19 KOS19321.1 - 6.6e-24 84.1 0.9 8.5e-24 83.8 0.9 1.2 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOS19321.1 - 1.8e-15 57.3 0.5 2.3e-15 56.9 0.5 1.2 1 0 0 1 1 1 1 HMG-box domain HMG_box_5 PF14887.6 KOS19321.1 - 0.025 14.6 1.7 0.039 13.9 1.7 1.3 1 0 0 1 1 1 0 HMG (high mobility group) box 5 GFO_IDH_MocA PF01408.22 KOS19323.1 - 2e-08 35.1 0.0 2.6e-06 28.2 0.0 2.4 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 KOS19323.1 - 0.00096 19.1 0.0 0.0029 17.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Herpes_pp85 PF04637.12 KOS19323.1 - 0.83 8.0 3.5 1.2 7.5 3.5 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) PGM_PMM_I PF02878.16 KOS19325.1 - 3.1e-33 114.4 0.0 4.8e-33 113.8 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 KOS19325.1 - 5.5e-26 91.0 0.0 8.9e-26 90.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 KOS19325.1 - 3.1e-16 59.8 0.0 6.4e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 KOS19325.1 - 2.9e-06 27.4 0.0 6.4e-06 26.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain RNase_T PF00929.24 KOS19326.1 - 8e-26 91.5 0.0 9.1e-26 91.4 0.0 1.0 1 0 0 1 1 1 1 Exonuclease SET PF00856.28 KOS19327.1 - 3.7e-08 34.0 0.3 3.1e-07 30.9 0.1 2.2 2 1 0 2 2 2 1 SET domain Ribosomal_S19 PF00203.21 KOS19328.1 - 3.5e-31 106.9 0.1 5e-31 106.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 NUDIX PF00293.28 KOS19329.1 - 0.00018 21.6 0.0 0.00038 20.5 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain IFRD_C PF04836.12 KOS19330.1 - 0.66 10.6 2.7 32 5.2 0.1 3.2 3 0 0 3 3 3 0 Interferon-related protein conserved region zf-C2H2 PF00096.26 KOS19332.1 - 4.8e-13 48.8 11.0 1.7e-06 28.1 0.4 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS19332.1 - 1.1e-08 35.0 11.1 1.8e-07 31.2 4.5 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS19332.1 - 3.1e-08 33.8 9.1 0.0018 19.0 0.3 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 KOS19332.1 - 7e-07 29.4 3.5 0.00027 21.2 0.2 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOS19332.1 - 5.9e-06 26.4 4.2 0.0032 17.7 0.6 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 KOS19332.1 - 0.001 19.0 14.6 0.0045 16.9 0.5 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 KOS19332.1 - 0.0037 16.9 3.0 0.4 10.4 0.1 2.4 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf-BED PF02892.15 KOS19332.1 - 0.027 14.5 1.5 0.027 14.5 1.5 2.2 1 1 1 2 2 2 0 BED zinc finger zf_UBZ PF18439.1 KOS19332.1 - 0.045 13.4 1.6 2.7 7.7 0.1 2.5 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_11 PF16622.5 KOS19332.1 - 0.38 10.5 5.4 8 6.3 0.0 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type Actin_micro PF17003.5 KOS19332.1 - 1.1 8.4 2.0 3.8 6.6 2.0 1.7 1 1 0 1 1 1 0 Putative actin-like family OrfB_Zn_ribbon PF07282.11 KOS19332.1 - 5.6 7.0 9.7 6.6 6.7 0.2 3.2 2 1 1 3 3 3 0 Putative transposase DNA-binding domain zf-C2HE PF16278.5 KOS19332.1 - 5.7 7.5 6.8 61 4.2 6.8 2.5 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 KOS19332.1 - 7.4 6.8 7.8 9 6.5 0.7 2.8 2 1 1 3 3 3 0 Zinc ribbon domain Glyco_hydro_16 PF00722.21 KOS19333.1 - 5.9e-38 130.1 1.2 8.8e-38 129.5 1.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Diphthami_syn_2 PF01902.17 KOS19334.1 - 4.7e-22 78.6 0.0 1.4e-16 60.7 0.0 3.3 3 0 0 3 3 3 3 Diphthamide synthase DUF202 PF02656.15 KOS19334.1 - 3.5e-20 72.2 1.6 3.5e-20 72.2 1.6 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Ribonuc_L-PSP PF01042.21 KOS19334.1 - 1.8e-11 44.1 0.3 1.4e-05 25.1 0.0 4.0 3 1 0 3 3 3 2 Endoribonuclease L-PSP Voldacs PF03517.13 KOS19334.1 - 3.8e-06 27.1 0.0 3.8e-06 27.1 0.0 3.3 4 0 0 4 4 4 1 Regulator of volume decrease after cellular swelling AAA_11 PF13086.6 KOS19335.1 - 3.6e-60 204.0 0.6 2.7e-59 201.1 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 KOS19335.1 - 8.8e-46 156.0 0.0 2e-45 154.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS19335.1 - 1.7e-12 47.4 0.0 4.7e-11 42.8 0.0 2.8 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS19335.1 - 8.6e-09 35.9 0.0 3.5e-08 33.9 0.0 2.1 2 1 0 2 2 1 1 AAA domain DUF2075 PF09848.9 KOS19335.1 - 1.1e-06 28.1 0.6 1.8e-05 24.1 0.3 2.7 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) UvrD-helicase PF00580.21 KOS19335.1 - 9.1e-06 25.4 0.0 5.2e-05 22.9 0.0 2.1 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 KOS19335.1 - 9.1e-06 25.8 0.0 4.4e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 KOS19335.1 - 4.8e-05 23.2 0.0 0.16 11.7 0.0 2.9 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase AAA_25 PF13481.6 KOS19335.1 - 0.00049 19.7 0.1 0.036 13.7 0.0 3.4 2 1 0 3 3 3 1 AAA domain Helicase_RecD PF05127.14 KOS19335.1 - 0.00055 19.8 0.0 0.034 14.0 0.0 2.4 2 0 0 2 2 2 1 Helicase T2SSE PF00437.20 KOS19335.1 - 0.00073 18.7 0.0 0.0015 17.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_16 PF13191.6 KOS19335.1 - 0.00082 19.8 0.7 0.002 18.5 0.1 2.0 2 0 0 2 2 1 1 AAA ATPase domain PhoH PF02562.16 KOS19335.1 - 0.00087 18.8 0.0 0.081 12.4 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 KOS19335.1 - 0.00096 19.4 0.2 0.016 15.4 0.2 2.6 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 KOS19335.1 - 0.0014 18.4 0.0 0.013 15.3 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 KOS19335.1 - 0.0035 17.3 0.0 0.015 15.3 0.0 2.0 2 0 0 2 2 2 1 Flavivirus DEAD domain TrwB_AAD_bind PF10412.9 KOS19335.1 - 0.0067 15.4 0.0 0.013 14.5 0.0 1.3 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 KOS19335.1 - 0.014 15.2 0.0 0.04 13.7 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA PF00004.29 KOS19335.1 - 0.015 15.8 0.5 0.072 13.5 0.0 2.4 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) 4HB_MCP_1 PF12729.7 KOS19335.1 - 0.016 14.7 0.1 0.035 13.6 0.1 1.5 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction AAA_5 PF07728.14 KOS19335.1 - 0.02 14.9 0.1 0.12 12.4 0.0 2.3 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 KOS19335.1 - 0.021 14.5 0.0 0.11 12.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain YflT PF11181.8 KOS19335.1 - 0.028 14.9 0.1 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 Heat induced stress protein YflT ABC_tran PF00005.27 KOS19335.1 - 0.067 13.7 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 ABC transporter NTPase_1 PF03266.15 KOS19335.1 - 0.1 12.5 0.3 2.1 8.2 0.0 2.6 2 0 0 2 2 2 0 NTPase PIF1 PF05970.14 KOS19335.1 - 0.12 11.5 0.0 2.8 7.0 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase Mg_chelatase PF01078.21 KOS19335.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ribosomal_L30_N PF08079.12 KOS19335.1 - 0.71 10.2 5.8 2.2 8.6 5.8 1.8 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain Topoisom_I PF01028.20 KOS19336.1 - 8e-97 323.0 5.1 2.1e-96 321.7 5.1 1.8 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 KOS19336.1 - 6.6e-93 310.1 6.0 6.6e-93 310.1 6.0 3.8 5 0 0 5 5 5 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 KOS19336.1 - 2.2e-31 107.6 0.5 2.2e-31 107.6 0.5 2.8 3 0 0 3 3 3 1 C-terminal topoisomerase domain ATP-synt PF00231.19 KOS19337.1 - 5.2e-80 269.1 4.7 6.2e-80 268.9 4.7 1.0 1 0 0 1 1 1 1 ATP synthase Amino_oxidase PF01593.24 KOS19338.1 - 8.1e-85 285.8 0.0 1.5e-83 281.6 0.0 2.2 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase SWIRM PF04433.17 KOS19338.1 - 8.7e-10 38.8 0.0 2.4e-09 37.4 0.0 1.7 2 0 0 2 2 2 1 SWIRM domain NAD_binding_8 PF13450.6 KOS19338.1 - 4.6e-08 33.2 0.1 1.3e-07 31.7 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HMG_box_2 PF09011.10 KOS19338.1 - 5.7e-08 33.2 1.6 1.3e-07 32.1 1.6 1.6 1 0 0 1 1 1 1 HMG-box domain HMG_box PF00505.19 KOS19338.1 - 6.3e-08 32.9 2.1 1.1e-07 32.1 0.9 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box DAO PF01266.24 KOS19338.1 - 0.00013 21.7 0.1 0.00024 20.8 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS19338.1 - 0.00057 19.2 0.1 0.0023 17.2 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase ApoO PF09769.9 KOS19339.1 - 3.7e-41 140.1 0.8 2.7e-40 137.3 0.0 2.1 2 0 0 2 2 2 1 Apolipoprotein O Peptidase_M3 PF01432.20 KOS19340.1 - 4.9e-115 385.4 0.0 9e-115 384.5 0.0 1.4 2 0 0 2 2 2 1 Peptidase family M3 Peptidase_M50B PF13398.6 KOS19340.1 - 0.082 12.5 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like MMR_HSR1 PF01926.23 KOS19341.1 - 7.1e-17 61.5 0.3 2.4e-15 56.6 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS19341.1 - 1.7e-07 30.9 0.1 8.8e-06 25.3 0.1 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 KOS19341.1 - 1.1e-06 28.6 1.2 0.0015 18.4 0.0 2.8 3 0 0 3 3 3 2 RsgA GTPase Sporozoite_P67 PF05642.11 KOS19341.1 - 0.0062 14.7 1.6 0.0083 14.3 1.6 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen AIG1 PF04548.16 KOS19341.1 - 0.0081 15.5 0.1 0.014 14.7 0.1 1.4 1 0 0 1 1 1 1 AIG1 family SAPS PF04499.15 KOS19341.1 - 0.038 12.8 3.8 0.057 12.2 3.8 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MeaB PF03308.16 KOS19341.1 - 0.044 12.8 0.1 0.094 11.7 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB TRAP_alpha PF03896.16 KOS19341.1 - 0.086 12.0 4.4 0.15 11.3 4.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Dynamin_N PF00350.23 KOS19341.1 - 0.26 11.3 10.3 0.19 11.7 0.7 3.3 3 1 0 3 3 3 0 Dynamin family RNA_pol_Rpc4 PF05132.14 KOS19341.1 - 0.29 11.6 3.2 0.66 10.4 3.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 KOS19341.1 - 0.34 9.2 7.9 0.46 8.7 7.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOS19341.1 - 0.76 8.5 4.4 1.1 7.9 4.4 1.1 1 0 0 1 1 1 0 Presenilin PGA2 PF07543.12 KOS19341.1 - 1.2 9.1 11.0 3 7.8 11.0 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 DNA_pol_phi PF04931.13 KOS19341.1 - 2.7 6.0 17.6 3.7 5.5 17.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi TEX19 PF15553.6 KOS19341.1 - 5 7.1 5.9 11 6.0 5.9 1.6 1 0 0 1 1 1 0 Testis-expressed protein 19 PTPRCAP PF15713.5 KOS19341.1 - 5.5 7.3 16.0 13 6.0 16.0 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Methyltr_RsmB-F PF01189.17 KOS19342.1 - 1.1e-73 247.2 0.0 1.7e-73 246.6 0.0 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 KOS19342.1 - 1.8e-07 31.5 0.0 4.3e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF PCMT PF01135.19 KOS19342.1 - 0.055 13.2 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Met_10 PF02475.16 KOS19342.1 - 0.057 13.2 0.0 1.3 8.8 0.0 2.1 2 0 0 2 2 2 0 Met-10+ like-protein DUF2431 PF10354.9 KOS19342.1 - 0.14 12.4 0.0 0.48 10.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2431) DKCLD PF08068.12 KOS19343.1 - 2.4e-33 114.0 0.3 1.4e-31 108.4 0.2 2.5 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_N PF01509.18 KOS19343.1 - 2.8e-22 79.7 5.2 1.5e-20 74.1 0.2 3.6 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KOS19343.1 - 5.7e-22 77.6 0.7 1.1e-21 76.7 0.7 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 KOS19343.1 - 3e-21 75.1 0.6 6.5e-21 74.1 0.6 1.6 1 0 0 1 1 1 1 PUA domain UPF0113 PF03657.13 KOS19343.1 - 0.00068 19.9 0.0 0.0016 18.7 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain RR_TM4-6 PF06459.12 KOS19343.1 - 4.1 7.2 11.0 5.9 6.6 11.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1351 PF07083.11 KOS19344.1 - 0.011 15.6 3.7 0.011 15.6 3.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1351) SAC3_GANP PF03399.16 KOS19345.1 - 2.6e-93 312.6 0.1 3e-93 312.4 0.1 1.0 1 0 0 1 1 1 1 SAC3/GANP family CRR7 PF12095.8 KOS19345.1 - 0.046 14.2 0.5 1.2 9.7 0.0 2.6 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 DER1 PF04511.15 KOS19346.1 - 7.5e-23 81.5 7.1 8.7e-23 81.3 7.1 1.0 1 0 0 1 1 1 1 Der1-like family Rhomboid PF01694.22 KOS19346.1 - 0.087 12.8 10.7 0.03 14.3 6.7 2.6 2 1 0 2 2 2 0 Rhomboid family DUF347 PF03988.12 KOS19348.1 - 0.073 13.3 0.0 0.12 12.6 0.0 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) EphA2_TM PF14575.6 KOS19348.1 - 0.096 13.6 0.0 0.19 12.6 0.0 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain SelK_SelG PF10961.8 KOS19348.1 - 0.27 11.9 2.2 0.31 11.7 0.6 1.8 2 0 0 2 2 2 0 Selenoprotein SelK_SelG PliI PF16743.5 KOS19351.1 - 0.17 11.6 0.1 0.45 10.3 0.1 1.6 1 0 0 1 1 1 0 Periplasmic lysozyme inhibitor of I-type lysozyme Bromodomain PF00439.25 KOS19352.1 - 9.1e-29 99.4 0.0 5.1e-15 55.3 0.0 2.5 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 KOS19352.1 - 2.6e-15 56.3 0.9 6e-15 55.2 0.9 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DMAP1 PF05499.12 KOS19352.1 - 0.00073 19.5 0.1 0.00073 19.5 0.1 3.8 4 0 0 4 4 4 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Utp12 PF04003.12 KOS19353.1 - 1.7e-23 82.9 0.0 2.6e-23 82.4 0.0 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family BUD22 PF09073.10 KOS19353.1 - 0.099 12.0 40.9 0.23 10.7 21.1 2.2 2 0 0 2 2 2 0 BUD22 NUDIX PF00293.28 KOS19355.1 - 5.4e-06 26.5 0.0 1.5e-05 25.0 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain Pkinase PF00069.25 KOS19356.1 - 4.2e-56 190.2 0.0 6e-56 189.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19356.1 - 1.4e-31 109.7 0.0 5.2e-30 104.6 0.0 2.1 2 0 0 2 2 2 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS19356.1 - 0.0072 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 KOS19356.1 - 0.0079 15.2 0.0 0.011 14.8 0.0 1.1 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Kdo PF06293.14 KOS19356.1 - 0.033 13.5 0.1 0.059 12.7 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family HSP70 PF00012.20 KOS19357.1 - 2.1e-08 32.8 0.1 1.4e-07 30.2 0.0 1.8 2 0 0 2 2 2 1 Hsp70 protein FtsA PF14450.6 KOS19357.1 - 0.0077 16.6 0.0 0.13 12.7 0.0 2.4 2 0 0 2 2 2 1 Cell division protein FtsA AA_permease PF00324.21 KOS19358.1 - 3.9e-98 329.1 46.4 4.7e-98 328.9 46.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS19358.1 - 2.4e-22 79.4 47.6 3.8e-22 78.7 47.6 1.2 1 0 0 1 1 1 1 Amino acid permease P_C PF06640.11 KOS19359.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 P protein C-terminus Fes1 PF08609.10 KOS19360.1 - 4.7e-32 110.7 1.7 2.2e-31 108.6 2.6 1.6 2 0 0 2 2 2 1 Nucleotide exchange factor Fes1 Arm PF00514.23 KOS19360.1 - 1.9e-07 30.9 1.1 0.0062 16.5 0.1 2.7 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 KOS19360.1 - 1.6e-06 27.9 1.5 0.0033 17.5 0.1 3.0 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 KOS19360.1 - 5.9e-06 26.6 2.7 2.1e-05 24.8 2.7 1.9 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 KOS19360.1 - 9e-06 26.1 1.9 9e-06 26.1 1.9 2.8 3 0 0 3 3 3 1 HEAT-like repeat V-ATPase_H_C PF11698.8 KOS19360.1 - 0.036 14.2 0.1 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 V-ATPase subunit H Ribosomal_L5_C PF00673.21 KOS19361.1 - 5.5e-29 100.2 0.0 1e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOS19361.1 - 3.3e-08 33.8 0.0 5.4e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L5 COX5A PF02284.16 KOS19362.1 - 6.5e-37 125.7 0.3 6.5e-37 125.7 0.3 1.4 2 0 0 2 2 2 1 Cytochrome c oxidase subunit Va Actin PF00022.19 KOS19363.1 - 1.2e-150 501.7 0.0 4.2e-150 499.9 0.0 1.7 1 1 0 1 1 1 1 Actin RAI1 PF08652.11 KOS19364.1 - 4e-27 94.2 0.0 8.1e-27 93.2 0.0 1.5 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease PAS_2 PF08446.11 KOS19364.1 - 0.046 14.4 0.0 0.082 13.6 0.0 1.4 1 0 0 1 1 1 0 PAS fold HDA2-3 PF11496.8 KOS19365.1 - 5.1e-05 22.6 1.8 0.00013 21.3 0.0 2.4 3 0 0 3 3 3 1 Class II histone deacetylase complex subunits 2 and 3 TMF_TATA_bd PF12325.8 KOS19365.1 - 0.001 19.3 0.5 0.001 19.3 0.5 3.6 2 1 0 3 3 3 1 TATA element modulatory factor 1 TATA binding DUF745 PF05335.13 KOS19365.1 - 0.0084 15.8 18.4 0.0084 15.8 18.4 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF745) KASH_CCD PF14662.6 KOS19365.1 - 0.47 10.2 23.6 0.073 12.9 14.3 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fib_alpha PF08702.10 KOS19365.1 - 2.8 8.1 16.9 4.5 7.5 4.1 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Transglut_core PF01841.19 KOS19366.1 - 3.6e-10 40.3 0.3 1e-09 38.8 0.3 1.8 1 0 0 1 1 1 1 Transglutaminase-like superfamily SARAF PF06682.12 KOS19366.1 - 0.57 9.8 5.9 0.98 9.0 5.9 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Pkinase PF00069.25 KOS19367.1 - 3e-68 230.0 0.0 4.1e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19367.1 - 7.6e-49 166.3 0.0 1.1e-48 165.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS19367.1 - 9.2e-08 31.3 0.0 1.4e-05 24.1 0.0 2.2 2 0 0 2 2 2 2 Fungal protein kinase Kinase-like PF14531.6 KOS19367.1 - 1e-05 25.0 0.0 4.1e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 KOS19367.1 - 0.068 13.1 0.0 23 4.8 0.0 3.1 2 1 0 3 3 3 0 Phosphotransferase enzyme family UCH_1 PF13423.6 KOS19368.1 - 1.2e-21 77.7 0.0 1.9e-10 40.9 0.0 3.2 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Porin_3 PF01459.22 KOS19369.1 - 1.2e-83 280.7 0.1 1.4e-83 280.5 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic porin Apq12 PF12716.7 KOS19371.1 - 1.5e-10 40.8 11.4 2.6e-10 40.1 11.4 1.4 1 0 0 1 1 1 1 Nuclear pore assembly and biogenesis WD40 PF00400.32 KOS19373.1 - 3.1e-49 163.9 19.7 2.1e-09 37.8 0.5 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19373.1 - 5.4e-21 74.7 0.0 0.0008 19.7 0.0 6.2 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS19373.1 - 6e-08 31.8 3.6 0.045 12.4 0.2 4.8 2 2 3 5 5 5 2 Nucleoporin Nup120/160 eIF2A PF08662.11 KOS19373.1 - 2.4e-06 27.6 0.0 0.00021 21.2 0.0 2.9 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOS19373.1 - 3.4e-06 26.2 0.5 0.31 10.0 0.0 4.6 2 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 KOS19373.1 - 0.0018 17.4 0.0 1.2 8.2 0.0 3.9 2 1 2 5 5 5 1 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 KOS19373.1 - 0.0039 15.8 0.0 0.054 12.0 0.0 2.2 2 0 0 2 2 2 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 KOS19373.1 - 0.025 13.5 0.8 8.1 5.3 0.0 3.1 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 KOS19373.1 - 0.047 12.0 0.0 1 7.6 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz WD40_like PF17005.5 KOS19373.1 - 0.05 12.9 0.0 0.22 10.8 0.0 1.9 2 0 0 2 2 2 0 WD40-like domain Nucleoporin_N PF08801.11 KOS19373.1 - 0.16 10.7 0.1 16 4.1 0.1 3.1 2 1 1 3 3 3 0 Nup133 N terminal like GPI-anchored PF10342.9 KOS19374.1 - 8e-18 65.0 0.6 8e-18 65.0 0.6 2.5 3 1 0 3 3 3 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family THF_DHG_CYH PF00763.23 KOS19375.1 - 6.8e-25 87.6 0.1 1.1e-24 87.0 0.1 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 KOS19375.1 - 1.8e-13 50.1 0.1 4.4e-08 32.6 0.0 2.4 2 0 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain adh_short PF00106.25 KOS19376.1 - 1.1e-09 38.0 0.5 1.2e-09 37.9 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS19376.1 - 1e-06 28.8 0.2 1.2e-06 28.6 0.2 1.0 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 KOS19376.1 - 9.5e-05 22.1 0.1 0.0001 21.9 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PDZ PF00595.24 KOS19376.1 - 0.038 14.3 0.0 0.053 13.9 0.0 1.2 1 0 0 1 1 1 0 PDZ domain Pkinase PF00069.25 KOS19377.1 - 2.2e-65 220.7 0.0 3.7e-65 219.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19377.1 - 6.4e-36 124.0 0.0 1e-35 123.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19377.1 - 0.00011 21.7 0.0 0.00025 20.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS19377.1 - 0.0028 17.6 0.0 0.0079 16.1 0.0 1.8 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOS19377.1 - 0.0058 15.4 0.0 0.014 14.2 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Seadorna_VP7 PF07387.11 KOS19377.1 - 0.061 12.4 0.0 0.12 11.4 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 dCMP_cyt_deam_1 PF00383.23 KOS19378.1 - 1.1e-08 34.9 1.4 1.3e-06 28.2 1.4 2.2 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 KOS19378.1 - 0.0042 16.7 3.3 0.19 11.3 0.2 2.2 1 1 1 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_2 PF08211.12 KOS19378.1 - 0.2 11.8 10.4 0.43 10.8 1.0 3.1 2 1 1 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region PI-PLC-X PF00388.19 KOS19381.1 - 4.5e-61 204.7 0.0 6.4e-61 204.2 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOS19381.1 - 3.1e-39 133.9 0.0 3.1e-39 133.9 0.0 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KOS19381.1 - 0.0031 17.8 0.0 3.6 7.9 0.0 2.6 2 0 0 2 2 2 2 C2 domain Trypan_PARP PF05887.11 KOS19381.1 - 0.042 13.8 8.7 0.086 12.8 8.7 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AF-4 PF05110.13 KOS19381.1 - 0.57 8.2 13.4 0.89 7.6 13.4 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein ALMT PF11744.8 KOS19381.1 - 0.87 8.3 7.9 1.3 7.8 7.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC27 PF09507.10 KOS19381.1 - 3.6 6.9 20.0 0.15 11.4 14.0 1.6 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 YL1 PF05764.13 KOS19381.1 - 8.4 6.4 24.7 0.12 12.4 16.6 1.9 2 0 0 2 2 2 0 YL1 nuclear protein Zn_clus PF00172.18 KOS19384.1 - 0.00029 20.9 13.0 0.0005 20.1 13.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Urb2 PF10441.9 KOS19385.1 - 3.8e-62 209.9 0.0 1.1e-61 208.3 0.0 1.9 1 0 0 1 1 1 1 Urb2/Npa2 family adh_short PF00106.25 KOS19386.1 - 2e-32 112.2 0.0 2.7e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS19386.1 - 1.8e-23 83.4 0.0 2.3e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS19386.1 - 1e-14 54.9 0.0 2.6e-14 53.5 0.0 1.6 1 1 0 1 1 1 1 KR domain DFP PF04127.15 KOS19386.1 - 0.02 14.8 0.1 0.033 14.0 0.1 1.3 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein 3HCDH_N PF02737.18 KOS19386.1 - 0.036 13.9 0.1 0.079 12.8 0.0 1.5 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.8 KOS19386.1 - 0.038 13.7 0.1 0.073 12.8 0.1 1.4 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Shikimate_DH PF01488.20 KOS19386.1 - 0.076 13.1 0.1 0.14 12.2 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KOS19386.1 - 0.08 13.4 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding NAD_binding_2 PF03446.15 KOS19386.1 - 0.08 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.6 KOS19386.1 - 0.095 12.6 0.0 0.27 11.1 0.0 1.7 2 0 0 2 2 2 0 NAD(P)H-binding ATP-synt_ab PF00006.25 KOS19386.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain THF_DHG_CYH_C PF02882.19 KOS19386.1 - 0.17 11.2 0.1 0.28 10.5 0.1 1.2 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NRDE-2 PF08424.10 KOS19387.1 - 1.3e-92 310.4 0.2 4.4e-91 305.4 0.5 2.2 2 0 0 2 2 2 1 NRDE-2, necessary for RNA interference TPR_19 PF14559.6 KOS19387.1 - 0.00093 19.7 6.4 0.071 13.6 0.5 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS19387.1 - 0.33 11.6 17.2 0.91 10.2 4.1 4.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOS19387.1 - 1.4 9.9 18.2 12 7.1 0.8 7.5 7 1 1 8 8 8 0 Tetratricopeptide repeat RFXA_RFXANK_bdg PF15289.6 KOS19388.1 - 0.0058 17.0 0.5 0.011 16.1 0.5 1.5 1 0 0 1 1 1 1 Regulatory factor X-associated C-terminal binding domain zf-C2H2_4 PF13894.6 KOS19388.1 - 0.0087 16.8 2.0 6.6 7.9 0.5 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS19388.1 - 0.011 16.2 1.5 1.1 9.9 0.0 2.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF753 PF05444.12 KOS19388.1 - 0.073 13.1 1.3 0.12 12.4 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF753) DNA_pol_B PF00136.21 KOS19388.1 - 0.11 11.1 0.8 0.16 10.7 0.8 1.1 1 0 0 1 1 1 0 DNA polymerase family B Med18 PF09637.10 KOS19390.1 - 1.1e-06 28.7 0.0 1.2e-06 28.5 0.0 1.0 1 0 0 1 1 1 1 Med18 protein Proteasome PF00227.26 KOS19391.1 - 1.3e-47 161.7 0.3 1.6e-47 161.5 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M22 PF00814.25 KOS19392.1 - 7e-43 147.3 0.1 1.3e-19 70.9 0.0 3.1 2 1 0 2 2 2 2 Glycoprotease family MFS_2 PF13347.6 KOS19394.1 - 8.1e-11 41.1 4.2 8.1e-11 41.1 4.2 2.7 3 0 0 3 3 3 1 MFS/sugar transport protein ESSS PF10183.9 KOS19394.1 - 0.17 12.1 0.0 0.61 10.3 0.0 2.0 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ribosomal_60s PF00428.19 KOS19394.1 - 5.5 7.6 7.7 1.9 9.1 4.8 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein MAPEG PF01124.18 KOS19395.1 - 1.8e-15 57.0 5.0 2.2e-15 56.7 5.0 1.1 1 0 0 1 1 1 1 MAPEG family Glyco_transf_34 PF05637.12 KOS19397.1 - 9.1e-64 215.4 0.9 1.3e-63 215.0 0.9 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 KOS19397.1 - 0.055 13.4 0.0 0.088 12.8 0.0 1.3 1 0 0 1 1 1 0 Nucleotide-diphospho-sugar transferase Glyco_hydro_16 PF00722.21 KOS19398.1 - 1.7e-10 40.6 0.1 8.4e-10 38.4 0.1 2.1 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 HdeA PF06411.11 KOS19398.1 - 0.37 11.0 1.9 1.6 9.0 0.1 2.4 2 0 0 2 2 2 0 HdeA/HdeB family EXOSC1 PF10447.9 KOS19401.1 - 1.2e-19 70.9 5.7 1.7e-14 54.3 0.3 2.4 1 1 1 2 2 2 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 KOS19401.1 - 7e-12 44.9 0.4 1.5e-11 43.9 0.4 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region ABC_membrane PF00664.23 KOS19402.1 - 6.2e-52 176.9 40.7 3.6e-35 122.0 18.2 3.1 3 0 0 3 3 3 3 ABC transporter transmembrane region ABC_tran PF00005.27 KOS19402.1 - 2.6e-45 154.3 0.1 7.9e-26 91.2 0.0 2.9 3 0 0 3 3 2 2 ABC transporter AAA_16 PF13191.6 KOS19402.1 - 1.8e-05 25.2 0.1 0.12 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 KOS19402.1 - 4.4e-05 23.4 0.4 0.065 13.1 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOS19402.1 - 4.8e-05 23.4 4.7 0.05 13.7 0.4 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase Zeta_toxin PF06414.12 KOS19402.1 - 7.9e-05 22.0 0.1 0.0063 15.8 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin AAA_29 PF13555.6 KOS19402.1 - 0.00017 21.2 2.0 0.21 11.4 0.1 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain MeaB PF03308.16 KOS19402.1 - 0.0027 16.7 1.9 0.74 8.7 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KOS19402.1 - 0.0037 17.0 2.2 1.5 8.5 0.1 2.8 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 KOS19402.1 - 0.0054 16.2 5.2 1.6 8.1 0.2 3.7 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 KOS19402.1 - 0.006 16.7 4.7 0.24 11.5 0.6 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_23 PF13476.6 KOS19402.1 - 0.009 16.5 2.8 4.2 7.8 0.1 3.2 3 0 0 3 3 3 1 AAA domain Dynamin_N PF00350.23 KOS19402.1 - 0.01 15.9 4.6 0.12 12.5 1.1 2.7 2 0 0 2 2 2 0 Dynamin family AAA_22 PF13401.6 KOS19402.1 - 0.026 14.8 1.1 12 6.2 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_21 PF13304.6 KOS19402.1 - 0.038 13.8 6.4 1.1 9.0 0.3 3.1 2 1 1 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Ploopntkinase3 PF18751.1 KOS19402.1 - 0.055 13.4 0.2 13 5.6 0.0 2.5 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 TrwB_AAD_bind PF10412.9 KOS19402.1 - 0.065 12.1 0.6 6.4 5.6 0.0 2.3 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Roc PF08477.13 KOS19402.1 - 0.095 12.9 0.2 13 6.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 KOS19402.1 - 0.19 11.2 0.8 7.2 6.1 0.1 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region AAA_27 PF13514.6 KOS19402.1 - 2.1 7.9 4.7 15 5.1 0.0 3.5 4 0 0 4 4 4 0 AAA domain TruB_N PF01509.18 KOS19403.1 - 1.2e-45 155.5 0.0 4.8e-45 153.6 0.0 1.9 2 0 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 KOS19403.1 - 1.7e-05 24.9 0.0 3.4e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Sec2p PF06428.11 KOS19404.1 - 5.7e-11 42.2 7.9 5.7e-11 42.2 7.9 1.6 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p Exonuc_VII_L PF02601.15 KOS19404.1 - 0.013 15.1 2.8 0.019 14.5 2.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCDC53 PF10152.9 KOS19404.1 - 0.03 14.7 11.3 0.036 14.5 7.9 2.7 1 1 2 3 3 3 0 Subunit CCDC53 of WASH complex Jnk-SapK_ap_N PF09744.9 KOS19404.1 - 0.11 12.7 13.0 0.024 14.9 9.8 1.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 GCN5L1 PF06320.13 KOS19404.1 - 0.47 10.6 3.9 0.76 10.0 3.9 1.3 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) SlyX PF04102.12 KOS19404.1 - 0.72 10.5 18.4 0.72 10.5 1.9 4.0 3 1 2 5 5 4 0 SlyX CytochromB561_N PF09786.9 KOS19404.1 - 1.5 7.7 9.5 1.9 7.4 9.5 1.3 1 0 0 1 1 1 0 Cytochrome B561, N terminal HAUS-augmin3 PF14932.6 KOS19404.1 - 2 7.9 9.3 3.8 7.0 9.3 1.5 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 SOG2 PF10428.9 KOS19404.1 - 3.2 6.9 17.1 4.4 6.4 17.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein VIR_N PF15912.5 KOS19404.1 - 4.7 6.7 6.0 8.8 5.8 6.0 1.5 1 1 0 1 1 1 0 Virilizer, N-terminal CAP_N PF01213.19 KOS19404.1 - 5.6 6.4 19.9 1.8 8.0 10.4 2.8 2 1 1 3 3 3 0 Adenylate cyclase associated (CAP) N terminal Ndc1_Nup PF09531.10 KOS19404.1 - 5.9 5.4 9.2 7.3 5.1 9.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MIF4G_like PF09088.11 KOS19405.1 - 1.1e-84 283.0 0.2 1.6e-84 282.5 0.2 1.3 1 0 0 1 1 1 1 MIF4G like MIF4G_like_2 PF09090.11 KOS19405.1 - 3.8e-57 193.8 0.0 5.5e-57 193.3 0.0 1.3 1 0 0 1 1 1 1 MIF4G like Hemocyanin_N PF03722.14 KOS19406.1 - 0.047 14.2 0.0 0.11 13.1 0.0 1.5 1 0 0 1 1 1 0 Hemocyanin, all-alpha domain 6PF2K PF01591.18 KOS19407.1 - 9.2e-57 191.9 0.0 1.8e-56 190.9 0.0 1.5 2 0 0 2 2 2 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOS19407.1 - 4.8e-22 78.6 0.2 1.6e-21 76.9 0.2 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) IstB_IS21 PF01695.17 KOS19407.1 - 0.059 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Pkinase PF00069.25 KOS19408.1 - 6.5e-40 137.2 0.3 5.6e-34 117.7 0.1 3.0 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19408.1 - 5.8e-11 42.2 0.0 7.8e-09 35.2 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOS19408.1 - 0.00013 21.4 0.0 0.00045 19.6 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 KOS19408.1 - 0.0037 17.2 0.0 0.0064 16.4 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KOS19408.1 - 0.077 12.0 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DUF1229 PF06797.11 KOS19408.1 - 0.087 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) Kdo PF06293.14 KOS19408.1 - 0.096 12.0 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 KOS19408.1 - 0.16 11.6 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase UPF0220 PF05255.11 KOS19410.1 - 3.4e-67 225.1 3.2 3.8e-67 225.0 3.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF5337 PF17272.2 KOS19410.1 - 0.33 10.8 3.0 0.34 10.7 1.0 2.1 1 1 0 1 1 1 0 Family of unknown function (DUF5337) EMP24_GP25L PF01105.24 KOS19411.1 - 1e-43 149.4 0.8 1.2e-43 149.2 0.8 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD NTase_sub_bind PF08780.11 KOS19411.1 - 0.079 12.9 0.1 0.13 12.3 0.1 1.3 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like MMtag PF10159.9 KOS19412.1 - 5e-31 106.8 3.6 8.9e-31 106.0 3.6 1.4 1 1 0 1 1 1 1 Multiple myeloma tumor-associated Mito_carr PF00153.27 KOS19413.1 - 1.9e-15 56.5 0.3 0.00017 21.4 0.1 4.9 5 0 0 5 5 5 4 Mitochondrial carrier protein T2SSM PF04612.12 KOS19414.1 - 0.0069 16.5 0.7 0.015 15.4 0.1 1.9 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein M SARAF PF06682.12 KOS19414.1 - 0.0093 15.7 0.0 0.0093 15.7 0.0 2.2 2 1 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis UL21a PF17636.2 KOS19414.1 - 0.024 14.7 0.2 0.05 13.6 0.2 1.5 1 0 0 1 1 1 0 Viral Unique Long protein 21a HemY_N PF07219.13 KOS19414.1 - 0.027 14.7 0.3 0.058 13.6 0.3 1.5 1 0 0 1 1 1 0 HemY protein N-terminus DUF846 PF05832.12 KOS19415.1 - 7e-51 171.9 5.0 8.6e-51 171.6 5.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Fcf1 PF04900.12 KOS19416.1 - 1.8e-29 102.1 0.0 3.2e-29 101.2 0.0 1.4 1 0 0 1 1 1 1 Fcf1 SbcCD_C PF13558.6 KOS19416.1 - 0.05 13.8 0.2 0.23 11.7 0.1 2.1 2 0 0 2 2 2 0 Putative exonuclease SbcCD, C subunit Sigma_reg_N PF13800.6 KOS19416.1 - 0.19 12.1 0.0 0.44 10.9 0.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Rtf2 PF04641.12 KOS19416.1 - 6.7 6.0 15.0 0.17 11.2 2.1 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger DUF726 PF05277.12 KOS19417.1 - 3.9e-127 423.9 3.4 5.3e-127 423.4 3.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF726) PE-PPE PF08237.11 KOS19417.1 - 0.013 15.1 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 PE-PPE domain Pkinase PF00069.25 KOS19418.1 - 1e-62 211.9 0.0 2.9e-62 210.4 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19418.1 - 9e-30 103.8 0.0 2.1e-29 102.6 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOS19418.1 - 1.9e-07 31.3 0.0 7.8e-07 29.4 0.0 2.1 1 0 0 1 1 1 1 FHA domain Kdo PF06293.14 KOS19418.1 - 0.0031 16.9 0.1 0.0067 15.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS19418.1 - 0.024 13.9 0.0 0.18 11.1 0.0 2.2 2 1 0 2 2 2 0 Kinase-like RIO1 PF01163.22 KOS19418.1 - 0.031 13.9 0.0 0.031 13.9 0.0 2.4 3 0 0 3 3 3 0 RIO1 family Yop-YscD_cpl PF16697.5 KOS19418.1 - 0.055 13.8 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 KOS19418.1 - 0.068 11.9 0.9 0.18 10.6 0.0 2.0 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 KOS19418.1 - 0.16 11.9 5.9 0.26 11.2 0.0 3.3 3 1 1 4 4 4 0 Phosphotransferase enzyme family PP2C_2 PF13672.6 KOS19419.1 - 0.00037 20.2 0.2 0.00063 19.4 0.2 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOS19419.1 - 0.022 14.7 0.1 0.15 11.9 0.0 2.3 2 1 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Inhibitor_I53 PF11714.8 KOS19420.1 - 0.0052 17.0 0.6 0.026 14.7 0.6 2.2 1 0 0 1 1 1 1 Thrombin inhibitor Madanin Mfp-3 PF04202.13 KOS19420.1 - 2.8 8.4 6.9 7.1 7.1 6.3 1.9 2 0 0 2 2 2 0 Foot protein 3 HpcH_HpaI PF03328.14 KOS19421.1 - 6.1e-43 146.5 0.1 6.9e-43 146.3 0.1 1.0 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 KOS19421.1 - 3.6e-06 26.4 0.0 0.0099 15.1 0.0 2.1 2 0 0 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold Malate_synthase PF01274.22 KOS19421.1 - 0.084 11.1 0.0 0.19 9.9 0.0 1.6 1 1 1 2 2 2 0 Malate synthase RRM_1 PF00076.22 KOS19422.1 - 1.2e-19 69.9 0.0 1.7e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS19422.1 - 0.00095 19.2 0.0 0.0015 18.6 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif PAP_PilO PF06864.12 KOS19422.1 - 0.047 12.5 0.1 0.059 12.2 0.1 1.1 1 0 0 1 1 1 0 Pilin accessory protein (PilO) DUF5320 PF17253.2 KOS19422.1 - 1.1 10.4 4.8 6.7 7.9 1.6 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF3984 PF13136.6 KOS19423.1 - 3.3e-60 204.2 24.1 5.8e-59 200.1 24.1 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3984) EMC1_C PF07774.13 KOS19424.1 - 4.4e-71 238.9 0.0 7.3e-71 238.2 0.0 1.4 1 0 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ_2 PF13360.6 KOS19424.1 - 1.4e-21 77.2 7.8 1.1e-17 64.4 3.5 2.5 2 0 0 2 2 2 2 PQQ-like domain PQQ PF01011.21 KOS19424.1 - 2.2e-05 24.2 1.0 0.032 14.2 0.0 4.8 5 0 0 5 5 5 1 PQQ enzyme repeat ATP_bind_3 PF01171.20 KOS19427.1 - 1.8e-34 119.1 3.2 1.2e-22 80.5 0.1 2.8 3 0 0 3 3 3 2 PP-loop family bZIP_1 PF00170.21 KOS19428.1 - 4.3e-08 33.1 6.4 4.3e-08 33.1 6.4 1.8 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 KOS19428.1 - 1.9e-05 24.6 4.0 1.9e-05 24.6 4.0 2.0 3 0 0 3 3 3 1 Basic region leucine zipper bZIP_Maf PF03131.17 KOS19428.1 - 0.0039 17.7 2.0 0.0039 17.7 2.0 2.3 2 0 0 2 2 2 1 bZIP Maf transcription factor TFIIA PF03153.13 KOS19428.1 - 0.078 13.0 15.0 0.11 12.5 15.0 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit XRCC4 PF06632.12 KOS19428.1 - 0.94 8.3 13.3 1.4 7.7 6.9 2.1 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Cyclin_N PF00134.23 KOS19430.1 - 1.2e-11 44.5 0.2 3.9e-11 42.8 0.1 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 KOS19430.1 - 0.0054 17.1 0.5 0.03 14.7 0.1 2.3 2 0 0 2 2 2 1 Cyclin C-terminal domain Turandot PF07240.11 KOS19430.1 - 0.099 12.6 0.2 0.21 11.6 0.2 1.5 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot Mito_carr PF00153.27 KOS19431.1 - 2.4e-70 232.5 3.9 1.1e-25 89.4 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 KOS19431.1 - 8.2e-22 75.1 9.3 2.4e-07 29.8 0.1 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 KOS19431.1 - 1.6e-20 73.3 6.9 1.6e-12 47.6 2.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 KOS19431.1 - 1.7e-18 65.2 11.4 5.7e-06 25.6 1.9 3.7 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 KOS19431.1 - 3e-16 57.9 13.5 3.3e-06 26.6 0.2 4.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 KOS19431.1 - 7e-14 51.4 5.3 2.3e-05 24.1 0.6 3.4 1 1 2 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 KOS19431.1 - 2e-07 31.3 0.1 0.00026 21.3 0.1 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Serine_protease PF18405.1 KOS19431.1 - 0.018 14.2 1.5 4.8 6.3 0.1 3.6 3 1 1 4 4 4 0 Gammaproteobacterial serine protease EF-hand_10 PF14788.6 KOS19431.1 - 0.054 13.4 0.7 10 6.1 0.1 2.7 3 0 0 3 3 3 0 EF hand EF-hand_4 PF12763.7 KOS19431.1 - 0.089 12.7 1.9 1.5 8.8 0.4 2.4 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 KOS19431.1 - 0.23 11.8 0.6 0.79 10.1 0.1 1.9 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 KOS19431.1 - 0.27 11.4 1.1 3.5 7.9 0.0 2.5 2 0 0 2 2 2 0 Dockerin type I domain DUF4097 PF13349.6 KOS19432.1 - 0.014 14.8 0.0 0.081 12.3 0.0 2.1 2 1 0 2 2 2 0 Putative adhesin FAM176 PF14851.6 KOS19433.1 - 0.055 13.1 1.1 0.059 13.0 1.1 1.1 1 0 0 1 1 1 0 FAM176 family DUF4452 PF14618.6 KOS19434.1 - 7.7e-75 250.4 11.7 9.8e-75 250.1 11.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4452) Pam16 PF03656.13 KOS19435.1 - 1.7e-06 28.1 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 KOS19435.1 - 2.9e-05 24.1 0.0 4.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain Ku_PK_bind PF08785.11 KOS19437.1 - 7.5e-33 113.2 0.0 1.4e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Ku C terminal domain like Ku PF02735.16 KOS19437.1 - 2.8e-20 72.9 0.0 9.1e-20 71.2 0.0 1.7 1 1 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KOS19437.1 - 3.1e-10 40.2 0.0 6e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain VWA PF00092.28 KOS19437.1 - 0.0019 18.5 0.0 0.015 15.6 0.0 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain Ku_C PF03730.14 KOS19437.1 - 0.034 14.9 0.1 0.17 12.6 0.0 2.1 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm DUF1175 PF06672.11 KOS19437.1 - 0.1 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1175) DUF4149 PF13664.6 KOS19438.1 - 1.8e-25 89.2 1.5 1.8e-25 89.2 1.5 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) DUF1772 PF08592.11 KOS19438.1 - 0.036 14.4 0.0 0.06 13.7 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) E1-E2_ATPase PF00122.20 KOS19439.1 - 6.5e-50 169.2 0.6 6.5e-50 169.2 0.6 2.5 2 1 0 2 2 2 1 E1-E2 ATPase HMA PF00403.26 KOS19439.1 - 1.8e-43 146.8 0.2 2.1e-11 44.1 0.1 4.5 4 0 0 4 4 4 4 Heavy-metal-associated domain Hydrolase PF00702.26 KOS19439.1 - 3.9e-40 138.4 2.1 3.9e-40 138.4 2.1 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOS19439.1 - 3.6e-06 26.9 1.7 3.1e-05 23.8 1.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase Pox_A12 PF04651.13 KOS19439.1 - 0.028 14.5 2.1 0.08 13.0 2.1 1.7 1 0 0 1 1 1 0 Poxvirus A12 protein HAD PF12710.7 KOS19439.1 - 0.13 12.7 0.1 0.39 11.1 0.1 1.9 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SR-25 PF10500.9 KOS19439.1 - 4.6 6.8 11.9 9.4 5.8 11.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NAGLU_N PF12971.7 KOS19441.1 - 0.18 11.6 0.1 0.35 10.7 0.1 1.3 1 0 0 1 1 1 0 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain zf-C2H2 PF00096.26 KOS19442.1 - 0.041 14.3 2.7 0.041 14.3 2.7 2.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type RGS PF00615.19 KOS19443.1 - 3.7e-11 43.3 0.0 1.7e-09 38.0 0.0 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain PCI PF01399.27 KOS19444.1 - 0.0011 19.5 0.0 0.0021 18.5 0.0 1.5 1 0 0 1 1 1 1 PCI domain CSN7a_helixI PF18392.1 KOS19444.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain Cation_efflux PF01545.21 KOS19445.1 - 1.8e-46 158.4 24.4 1.1e-45 155.8 24.4 1.9 1 1 0 1 1 1 1 Cation efflux family Cyclin_N PF00134.23 KOS19447.1 - 2.8e-36 124.0 0.1 5.1e-36 123.2 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOS19447.1 - 9.3e-13 48.3 0.4 3.5e-12 46.4 0.4 2.0 1 1 0 1 1 1 1 Cyclin, C-terminal domain 2-Hacid_dh_C PF02826.19 KOS19449.1 - 9.4e-51 171.7 0.0 1.4e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOS19449.1 - 1.6e-18 66.6 0.0 2.1e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOS19449.1 - 0.00015 22.0 0.0 0.00024 21.3 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 KOS19449.1 - 0.089 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain CoA_transf_3 PF02515.17 KOS19449.1 - 0.14 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 CoA-transferase family III Pkinase PF00069.25 KOS19450.1 - 1.1e-40 139.6 0.0 1.6e-40 139.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19450.1 - 1e-28 100.3 0.0 1.5e-28 99.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS19450.1 - 0.00048 20.1 0.4 1.6 8.6 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.14 KOS19450.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS19450.1 - 0.12 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like HeLo PF14479.6 KOS19452.1 - 1.3e-44 152.5 0.8 2.1e-44 151.8 0.8 1.3 1 0 0 1 1 1 1 Prion-inhibition and propagation Zn_clus PF00172.18 KOS19453.1 - 4.9e-10 39.4 7.0 9.6e-10 38.4 7.0 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOS19453.1 - 1.1e-06 27.9 0.9 9e-06 24.9 0.5 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain ABC2_membrane PF01061.24 KOS19454.1 - 1.8e-32 112.4 22.5 2.7e-32 111.9 22.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC_tran PF00005.27 KOS19454.1 - 3.8e-25 89.0 0.1 5.8e-25 88.4 0.1 1.3 1 0 0 1 1 1 1 ABC transporter ABC2_membrane_3 PF12698.7 KOS19454.1 - 9.2e-06 25.0 13.0 1.3e-05 24.5 13.0 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein SMC_N PF02463.19 KOS19454.1 - 1.2e-05 24.9 0.1 2e-05 24.2 0.1 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KOS19454.1 - 1.5e-05 25.0 0.0 0.001 19.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_21 PF13304.6 KOS19454.1 - 2.1e-05 24.5 0.0 0.031 14.1 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOS19454.1 - 0.00011 22.6 0.1 0.00021 21.7 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 KOS19454.1 - 0.00011 21.8 0.0 0.00028 20.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS19454.1 - 0.0007 19.9 0.0 0.0026 18.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 KOS19454.1 - 0.0022 18.4 0.1 0.021 15.3 0.1 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) PDR_CDR PF06422.12 KOS19454.1 - 0.0061 16.4 0.0 0.024 14.5 0.0 2.1 1 0 0 1 1 1 1 CDR ABC transporter AAA_28 PF13521.6 KOS19454.1 - 0.0061 16.8 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOS19454.1 - 0.0064 16.4 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 KOS19454.1 - 0.013 16.1 0.0 0.029 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOS19454.1 - 0.019 15.1 0.0 0.037 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOS19454.1 - 0.021 14.4 0.0 0.054 13.1 0.0 1.7 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_29 PF13555.6 KOS19454.1 - 0.038 13.7 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 KOS19454.1 - 0.051 13.6 0.0 0.24 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) NACHT PF05729.12 KOS19454.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 NACHT domain IstB_IS21 PF01695.17 KOS19454.1 - 0.096 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein MMR_HSR1 PF01926.23 KOS19454.1 - 0.098 12.7 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 KOS19454.1 - 0.11 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOS19454.1 - 0.13 12.0 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOS19454.1 - 0.15 11.6 0.0 0.36 10.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 KOS19454.1 - 0.15 12.4 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 RNA helicase DUF423 PF04241.15 KOS19454.1 - 3.2 8.0 6.4 1.2 9.4 0.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF423) MNHE PF01899.16 KOS19454.1 - 8.3 6.2 9.0 6.2 6.6 5.4 2.3 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit Cytochrom_B561 PF03188.16 KOS19455.1 - 3e-07 30.7 10.1 3e-07 30.7 10.1 1.5 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 KOS19455.1 - 0.0018 18.1 6.6 0.0018 18.1 6.6 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DUF668 PF05003.12 KOS19455.1 - 0.0019 18.6 0.0 0.0042 17.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF668) DUF4079 PF13301.6 KOS19455.1 - 5.9 7.0 13.3 17 5.6 9.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF4079) HAD_2 PF13419.6 KOS19456.1 - 5.7e-06 26.5 0.0 8.7e-05 22.7 0.0 2.0 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS19456.1 - 0.06 13.6 0.0 0.12 12.6 0.0 1.6 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase bZIP_1 PF00170.21 KOS19457.1 - 0.00074 19.6 3.4 0.00074 19.6 3.4 2.3 3 0 0 3 3 2 1 bZIP transcription factor TFIIA PF03153.13 KOS19457.1 - 0.0023 18.0 23.8 0.0023 18.0 23.8 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 KOS19457.1 - 0.027 14.0 5.0 0.045 13.2 5.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PP2C_2 PF13672.6 KOS19457.1 - 0.19 11.3 0.1 0.19 11.3 0.1 2.1 2 0 0 2 2 2 0 Protein phosphatase 2C Velvet PF11754.8 KOS19457.1 - 0.5 10.3 12.9 0.021 14.8 6.2 1.9 2 0 0 2 2 2 0 Velvet factor Hid1 PF12722.7 KOS19457.1 - 0.59 8.2 7.2 0.87 7.6 7.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RR_TM4-6 PF06459.12 KOS19457.1 - 0.97 9.2 10.9 0.07 12.9 4.8 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 KOS19457.1 - 1.3 9.0 17.6 0.05 13.6 11.5 1.6 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4175 PF13779.6 KOS19457.1 - 1.6 6.6 27.2 3 5.6 27.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Spt20 PF12090.8 KOS19457.1 - 2.5 7.6 38.5 5.2 6.6 38.5 1.5 1 0 0 1 1 1 0 Spt20 family MDM31_MDM32 PF08118.11 KOS19457.1 - 3.2 6.3 6.9 5 5.7 6.9 1.2 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins ALMT PF11744.8 KOS19457.1 - 5.5 5.7 7.6 10 4.8 7.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter PAT1 PF09770.9 KOS19457.1 - 6.4 4.9 25.6 0.21 9.8 19.8 1.4 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 VWA_3 PF13768.6 KOS19458.1 - 3.7e-22 78.9 0.0 7.9e-22 77.9 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOS19458.1 - 1.5e-11 44.9 0.0 2.5e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 KOS19458.1 - 2.6e-08 34.4 0.0 4.6e-08 33.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 KOS19458.1 - 2.8e-06 26.9 0.0 4.7e-06 26.1 0.0 1.4 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Copine PF07002.16 KOS19458.1 - 0.12 11.8 0.0 0.2 11.1 0.0 1.2 1 0 0 1 1 1 0 Copine Sugar_tr PF00083.24 KOS19459.1 - 2.2e-86 290.5 20.4 2.5e-86 290.4 20.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS19459.1 - 9e-17 61.0 32.3 3.5e-15 55.8 29.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Jagunal PF07086.12 KOS19459.1 - 0.51 10.4 3.0 0.99 9.5 0.2 2.5 3 0 0 3 3 3 0 Jagunal, ER re-organisation during oogenesis Brr6_like_C_C PF10104.9 KOS19460.1 - 1.5e-37 128.4 4.2 2.5e-37 127.7 4.2 1.3 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Med26 PF08711.11 KOS19461.1 - 2.3e-10 40.3 0.0 5.6e-10 39.1 0.0 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Osmo_CC PF08946.10 KOS19461.1 - 4.7 7.5 7.2 12 6.2 0.1 3.3 3 0 0 3 3 3 0 Osmosensory transporter coiled coil RNA_pol_Rpb1_1 PF04997.12 KOS19462.1 - 5e-79 265.9 0.1 8.7e-79 265.1 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 KOS19462.1 - 5.1e-79 265.5 0.0 7.4e-79 264.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KOS19462.1 - 2.1e-73 246.0 0.0 1.6e-72 243.2 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KOS19462.1 - 9.5e-34 116.6 0.0 3e-33 115.0 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KOS19462.1 - 3.4e-30 104.2 0.1 1.2e-29 102.4 0.1 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Pyr_redox_3 PF13738.6 KOS19463.1 - 1.9e-16 60.2 0.1 2.6e-14 53.2 0.0 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS19463.1 - 3.6e-14 52.7 0.0 1.4e-11 44.2 0.0 2.5 2 1 1 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 KOS19463.1 - 2.8e-11 42.5 0.0 1e-08 34.1 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 KOS19463.1 - 9.3e-11 41.4 0.1 1.7e-08 34.0 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOS19463.1 - 4e-06 27.0 0.0 0.00011 22.4 0.0 2.8 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOS19463.1 - 4.3e-06 26.2 0.0 0.0025 17.1 0.0 2.7 3 0 0 3 3 3 2 FAD binding domain Pyr_redox PF00070.27 KOS19463.1 - 7.5e-06 26.4 0.2 0.03 14.9 0.0 2.9 3 0 0 3 3 2 2 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 KOS19463.1 - 0.00041 19.8 0.2 0.024 14.0 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 KOS19463.1 - 0.00047 20.2 0.2 1 9.4 0.0 2.5 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 KOS19463.1 - 0.0016 18.7 0.2 0.075 13.3 0.0 2.8 3 1 0 3 3 2 1 TrkA-N domain FAD_binding_2 PF00890.24 KOS19463.1 - 0.0034 16.5 1.6 0.052 12.6 0.2 2.2 2 0 0 2 2 2 1 FAD binding domain IlvN PF07991.12 KOS19463.1 - 0.0066 16.0 1.4 0.12 11.9 0.3 2.2 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain HI0933_like PF03486.14 KOS19463.1 - 0.0067 15.2 0.1 0.022 13.5 0.1 1.8 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_7 PF13241.6 KOS19463.1 - 0.007 16.8 0.0 0.22 11.9 0.2 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding Amino_oxidase PF01593.24 KOS19463.1 - 0.017 14.5 0.0 4.9 6.3 0.0 3.1 3 0 0 3 3 3 0 Flavin containing amine oxidoreductase ApbA PF02558.16 KOS19463.1 - 0.026 14.1 0.0 1.7 8.3 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 KOS19463.1 - 0.033 14.8 0.6 0.83 10.3 0.2 2.5 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 KOS19463.1 - 0.034 14.0 0.6 3.8 7.4 0.1 2.3 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 KOS19463.1 - 0.036 13.1 0.1 0.097 11.7 0.0 1.7 2 0 0 2 2 2 0 Lycopene cyclase protein SnoaL_2 PF12680.7 KOS19463.1 - 0.039 14.6 1.7 1.5 9.6 0.1 2.8 2 0 0 2 2 2 0 SnoaL-like domain AlaDh_PNT_C PF01262.21 KOS19463.1 - 0.074 12.3 0.0 0.12 11.6 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 KOS19463.1 - 0.19 10.8 0.8 1 8.4 0.2 2.2 3 0 0 3 3 3 0 Glucose inhibited division protein A PUL PF08324.11 KOS19465.1 - 8e-70 235.2 0.1 1.1e-69 234.8 0.1 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 KOS19465.1 - 1.9e-43 147.3 0.3 3.1e-43 146.6 0.3 1.3 1 0 0 1 1 1 1 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 KOS19465.1 - 3.8e-30 103.5 13.7 1.8e-06 28.5 0.0 8.5 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19465.1 - 0.028 14.7 0.4 2.6 8.4 0.0 3.8 4 1 1 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 KOS19465.1 - 0.032 14.7 0.1 0.2 12.2 0.1 2.4 1 0 0 1 1 1 0 PQQ-like domain BBS2_Mid PF14783.6 KOS19465.1 - 0.071 13.2 0.0 19 5.3 0.0 3.2 1 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 KOS19466.1 - 1.6e-12 47.7 0.1 1.9e-08 34.8 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19466.1 - 7.9e-05 22.9 0.0 0.067 13.5 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS19466.1 - 0.0023 16.9 0.0 0.0036 16.3 0.0 1.2 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein tRNA-synt_2d PF01409.20 KOS19467.1 - 2.8e-83 279.2 0.0 4e-83 278.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 KOS19467.1 - 1.1e-18 67.2 0.1 2.7e-18 66.0 0.1 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 3 tRNA_synthFbeta PF17759.1 KOS19467.1 - 2e-06 27.4 0.1 0.0015 18.0 0.0 3.0 3 0 0 3 3 3 2 Phenylalanyl tRNA synthetase beta chain CLM domain PheRS_DBD2 PF18554.1 KOS19467.1 - 1.1e-05 25.3 2.0 7.9e-05 22.6 3.0 2.0 2 0 0 2 2 2 1 PheRS DNA binding domain 2 tRNA-synt_2 PF00152.20 KOS19467.1 - 0.00019 20.7 0.2 0.0065 15.6 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 KOS19467.1 - 0.13 12.3 0.0 0.58 10.1 0.0 2.0 1 1 1 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) MDM1 PF15501.6 KOS19468.1 - 0.00039 19.7 18.7 0.00049 19.4 18.7 1.1 1 0 0 1 1 1 1 Nuclear protein MDM1 Nop14 PF04147.12 KOS19468.1 - 0.0019 16.5 32.1 0.0024 16.2 32.1 1.0 1 0 0 1 1 1 1 Nop14-like family Zip PF02535.22 KOS19468.1 - 0.048 12.9 9.1 0.059 12.6 9.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Caldesmon PF02029.15 KOS19468.1 - 0.078 11.7 34.6 0.1 11.3 34.6 1.1 1 0 0 1 1 1 0 Caldesmon Sporozoite_P67 PF05642.11 KOS19468.1 - 0.29 9.2 9.3 0.37 8.8 9.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 KOS19468.1 - 0.52 9.0 28.4 0.71 8.6 28.4 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KOS19468.1 - 0.67 8.2 32.5 0.87 7.8 32.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 KOS19468.1 - 1.6 7.4 24.3 3 6.5 24.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Lin-8 PF03353.15 KOS19468.1 - 2.9 7.4 30.2 3.6 7.1 30.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CCSAP PF15748.5 KOS19468.1 - 3.6 7.7 30.1 5.2 7.2 30.1 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated BUD22 PF09073.10 KOS19468.1 - 4.6 6.5 35.4 6.1 6.1 35.4 1.1 1 0 0 1 1 1 0 BUD22 MMR1 PF08505.10 KOS19468.1 - 4.9 7.4 18.9 7.2 6.8 18.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Apt1 PF10351.9 KOS19468.1 - 6.8 5.4 13.9 8.8 5.0 13.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4045 PF13254.6 KOS19468.1 - 9.3 5.8 24.7 13 5.3 24.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) 5_nucleotid_C PF02872.18 KOS19469.1 - 0.0085 16.3 0.0 0.019 15.2 0.0 1.5 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain DUF4185 PF13810.6 KOS19470.1 - 1.2e-08 34.5 1.1 1.7e-08 34.0 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4185) DUF5005 PF16396.5 KOS19470.1 - 7.9e-07 28.1 0.7 1.1e-06 27.6 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5005) DUF1776 PF08643.10 KOS19471.1 - 3e-100 335.4 0.0 3.8e-100 335.1 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) HATPase_c PF02518.26 KOS19472.1 - 1.1e-28 100.0 0.1 2e-28 99.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS19472.1 - 8.3e-23 80.7 0.1 2.2e-22 79.3 0.1 1.8 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 KOS19472.1 - 8.3e-21 73.8 0.0 2.3e-20 72.4 0.0 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 KOS19472.1 - 2.3e-17 63.0 1.0 1.1e-16 60.9 0.2 2.7 3 0 0 3 3 3 1 PAS fold PAS PF00989.25 KOS19472.1 - 2.1e-16 59.9 0.0 3.4e-10 39.9 0.0 2.7 2 0 0 2 2 2 2 PAS fold PAS_9 PF13426.7 KOS19472.1 - 5.2e-15 55.6 0.0 9e-10 38.8 0.0 3.7 3 0 0 3 3 3 2 PAS domain PAS_4 PF08448.10 KOS19472.1 - 4.5e-12 46.2 0.5 5.4e-08 33.1 0.0 3.9 3 1 0 3 3 3 2 PAS fold PAS_8 PF13188.7 KOS19472.1 - 1.7e-08 34.3 0.0 2.2e-05 24.4 0.0 3.3 3 0 0 3 3 3 2 PAS domain PAS_11 PF14598.6 KOS19472.1 - 0.00067 19.8 0.0 0.0015 18.6 0.0 1.5 1 0 0 1 1 1 1 PAS domain MLTR_LBD PF17765.1 KOS19472.1 - 0.0011 19.1 0.1 0.017 15.2 0.0 2.5 2 0 0 2 2 2 1 MmyB-like transcription regulator ligand binding domain Amidase PF01425.21 KOS19473.1 - 2.2e-93 313.7 0.0 3.2e-93 313.1 0.0 1.3 1 1 0 1 1 1 1 Amidase PapJ PF14855.6 KOS19474.1 - 0.057 13.1 0.1 0.083 12.6 0.1 1.1 1 0 0 1 1 1 0 Pilus-assembly fibrillin subunit, chaperone Syntaxin PF00804.25 KOS19475.1 - 7.2e-18 65.0 14.6 7.2e-18 65.0 14.6 2.1 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 KOS19475.1 - 1.1e-13 51.0 1.2 1.1e-13 51.0 1.2 3.3 4 1 1 5 5 5 1 SNARE domain ODV-E18 PF10717.9 KOS19475.1 - 0.00017 21.4 1.1 0.00023 21.0 0.1 1.7 2 0 0 2 2 2 1 Occlusion-derived virus envelope protein ODV-E18 Orf78 PF06024.12 KOS19475.1 - 0.0037 17.5 1.0 0.0073 16.6 0.1 1.9 2 0 0 2 2 2 1 Orf78 (ac78) Mod_r PF07200.13 KOS19475.1 - 0.0067 16.5 7.2 0.43 10.7 3.0 2.8 1 1 1 2 2 2 2 Modifier of rudimentary (Mod(r)) protein ASFV_J13L PF05568.11 KOS19475.1 - 0.014 15.1 0.2 0.03 14.1 0.2 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein Mid2 PF04478.12 KOS19475.1 - 0.027 14.3 2.2 0.065 13.1 2.2 1.6 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Chordopox_A33R PF05966.12 KOS19475.1 - 1.1 8.5 3.3 1.1 8.5 0.2 2.3 3 0 0 3 3 3 0 Chordopoxvirus A33R protein Syntaxin-6_N PF09177.11 KOS19475.1 - 2.3 8.8 8.7 1.1 9.9 1.4 3.2 1 1 1 3 3 3 0 Syntaxin 6, N-terminal zf-CCCH PF00642.24 KOS19476.1 - 6.8e-24 83.2 32.8 3.8e-08 33.0 0.7 5.3 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 KOS19476.1 - 1e-19 69.9 33.6 7.4e-06 25.8 3.7 5.3 5 0 0 5 5 5 4 Zinc finger domain Torus PF16131.5 KOS19476.1 - 1.8e-11 44.7 24.7 3.6e-05 24.4 0.8 5.3 1 1 4 5 5 5 4 Torus domain zf-CCCH_4 PF18044.1 KOS19476.1 - 5.5e-10 38.8 35.9 1.1e-05 25.1 1.4 5.3 5 0 0 5 5 5 4 CCCH-type zinc finger FAM27 PF15832.5 KOS19476.1 - 3.1 8.4 18.6 1.7 9.2 12.6 2.5 2 1 0 2 2 2 0 FAM27 D and E protein family DNA_pol_viral_C PF00336.18 KOS19477.1 - 0.074 12.4 0.0 0.081 12.3 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase (viral) C-terminal domain DUF5337 PF17272.2 KOS19478.1 - 0.21 11.4 1.2 0.47 10.3 1.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5337) NAD_binding_6 PF08030.12 KOS19479.1 - 9.2e-24 84.3 0.0 1.5e-23 83.7 0.0 1.3 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS19479.1 - 1.2e-22 80.0 0.0 2.5e-22 79.0 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 KOS19479.1 - 1.5e-21 76.8 13.2 4e-21 75.4 8.9 2.5 1 1 1 2 2 2 2 Ferric reductase like transmembrane component NAD_binding_1 PF00175.21 KOS19479.1 - 0.065 13.9 0.0 2.3 8.9 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain MCM PF00493.23 KOS19480.1 - 2.3e-103 344.1 0.0 4.2e-103 343.3 0.0 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOS19480.1 - 2.3e-29 101.8 0.9 4e-29 101.0 0.9 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 KOS19480.1 - 1.6e-20 73.3 1.3 4.5e-20 71.9 1.3 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 KOS19480.1 - 5.4e-20 71.9 1.3 2.8e-19 69.6 0.1 2.4 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOS19480.1 - 2.1e-07 30.6 0.1 1.2e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOS19480.1 - 5e-07 29.8 0.0 2.1e-06 27.8 0.0 2.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 KOS19480.1 - 0.001 18.9 0.9 0.005 16.7 0.1 2.5 2 0 0 2 2 2 1 AAA lid domain Mg_chelatase_C PF13335.6 KOS19480.1 - 0.004 17.8 0.2 0.004 17.8 0.2 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 KOS19480.1 - 0.0088 15.9 0.0 0.029 14.2 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS19480.1 - 0.15 11.8 0.0 0.74 9.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain DAP3 PF10236.9 KOS19481.1 - 2.7e-86 289.6 0.0 3.5e-86 289.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 KOS19481.1 - 0.068 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Retinal PF15449.6 KOS19481.1 - 0.62 7.8 4.9 0.84 7.3 4.9 1.1 1 0 0 1 1 1 0 Retinal protein RRS1 PF04939.12 KOS19482.1 - 3.4e-60 202.6 5.6 3.9e-60 202.4 5.6 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) TonB_N PF16031.5 KOS19482.1 - 0.018 15.6 2.0 0.018 15.6 2.0 2.2 2 0 0 2 2 2 0 TonB polyproline region RhoGAP PF00620.27 KOS19483.1 - 1.5e-21 76.8 0.1 7.7e-21 74.5 0.1 2.0 1 1 0 1 1 1 1 RhoGAP domain ABC_tran PF00005.27 KOS19484.1 - 5e-35 121.0 0.0 5.7e-17 62.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOS19484.1 - 9.3e-13 48.1 0.5 1.9e-05 24.2 0.0 3.4 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 KOS19484.1 - 2.5e-12 46.4 4.6 2.5e-12 46.4 4.6 2.0 2 0 0 2 2 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 KOS19484.1 - 1.2e-11 45.0 5.6 0.099 12.4 0.0 4.2 2 2 2 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOS19484.1 - 7e-06 26.5 0.0 0.012 16.1 0.0 2.4 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 KOS19484.1 - 9e-06 26.0 0.0 0.0022 18.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Fer4 PF00037.27 KOS19484.1 - 9.8e-06 25.2 2.7 9.8e-06 25.2 2.7 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain AAA_15 PF13175.6 KOS19484.1 - 1.8e-05 24.7 0.0 0.22 11.2 0.0 3.0 3 1 0 4 4 3 2 AAA ATPase domain AAA PF00004.29 KOS19484.1 - 4.6e-05 23.8 0.0 0.031 14.7 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Fer4_10 PF13237.6 KOS19484.1 - 9.5e-05 22.4 8.6 0.0046 17.1 0.1 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Rad17 PF03215.15 KOS19484.1 - 0.00039 20.4 0.0 0.04 13.8 0.0 2.5 2 1 0 2 2 2 1 Rad17 P-loop domain RsgA_GTPase PF03193.16 KOS19484.1 - 0.00044 20.2 0.1 1.1 9.2 0.0 2.7 2 0 0 2 2 2 2 RsgA GTPase AAA_18 PF13238.6 KOS19484.1 - 0.00046 20.7 0.0 1.7 9.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain Fer4_21 PF14697.6 KOS19484.1 - 0.00047 20.2 10.2 0.00093 19.3 10.2 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_29 PF13555.6 KOS19484.1 - 0.00048 19.8 0.1 0.61 9.9 0.0 2.7 2 0 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 KOS19484.1 - 0.0005 20.4 0.0 0.32 11.4 0.0 2.8 2 0 0 2 2 2 1 RNA helicase AAA_23 PF13476.6 KOS19484.1 - 0.0007 20.2 0.3 0.14 12.7 0.2 2.6 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 KOS19484.1 - 0.0013 18.7 0.1 0.35 10.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain Thymidylate_kin PF02223.17 KOS19484.1 - 0.0023 17.6 0.3 1.7 8.3 0.0 3.1 3 0 0 3 3 3 1 Thymidylate kinase AAA_33 PF13671.6 KOS19484.1 - 0.0025 18.0 0.0 0.64 10.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 KOS19484.1 - 0.0031 17.2 2.8 0.086 12.5 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_6 PF12837.7 KOS19484.1 - 0.0032 17.5 1.7 0.0032 17.5 1.7 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_24 PF13479.6 KOS19484.1 - 0.0039 16.9 1.6 0.35 10.5 0.1 2.4 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 KOS19484.1 - 0.0049 16.9 0.1 0.058 13.4 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Fer4_7 PF12838.7 KOS19484.1 - 0.008 16.7 7.1 0.012 16.2 0.3 2.5 2 0 0 2 2 2 1 4Fe-4S dicluster domain AAA_28 PF13521.6 KOS19484.1 - 0.015 15.5 0.1 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KOS19484.1 - 0.019 15.0 1.2 0.39 10.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 KOS19484.1 - 0.019 14.7 0.3 1.5 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_13 PF13166.6 KOS19484.1 - 0.022 13.4 0.0 0.022 13.4 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KOS19484.1 - 0.023 14.2 0.3 0.38 10.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region NB-ARC PF00931.22 KOS19484.1 - 0.033 13.4 0.0 5.3 6.2 0.0 2.9 3 0 0 3 3 3 0 NB-ARC domain Fer4_9 PF13187.6 KOS19484.1 - 0.038 14.1 10.6 0.082 13.1 10.6 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOS19484.1 - 0.1 13.6 0.3 0.1 13.6 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain MMR_HSR1 PF01926.23 KOS19484.1 - 0.13 12.3 0.9 18 5.5 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase VirE PF05272.11 KOS19484.1 - 0.18 11.6 0.0 7 6.3 0.0 2.3 2 0 0 2 2 2 0 Virulence-associated protein E PduV-EutP PF10662.9 KOS19484.1 - 0.23 11.2 3.6 0.69 9.7 0.1 2.8 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation CLP1_P PF16575.5 KOS19484.1 - 0.49 10.2 1.7 1.3 8.8 0.1 2.2 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop NTPase_1 PF03266.15 KOS19484.1 - 0.55 10.1 3.8 4 7.3 0.1 2.7 3 0 0 3 3 2 0 NTPase Fer4_2 PF12797.7 KOS19484.1 - 0.65 10.2 10.6 0.3 11.3 1.0 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain SNF2_N PF00176.23 KOS19485.1 - 1.2e-53 182.0 0.0 2.2e-53 181.2 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 KOS19485.1 - 1.8e-26 91.8 8.0 1.5e-16 60.0 2.5 3.0 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 KOS19485.1 - 1.1e-18 67.6 0.0 2.9e-18 66.2 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4208 PF13907.6 KOS19485.1 - 3.9e-10 40.0 0.3 2e-09 37.7 0.0 2.5 2 0 0 2 2 1 1 Domain of unknown function (DUF4208) HDA2-3 PF11496.8 KOS19485.1 - 6.7e-10 38.6 0.0 2.3e-09 36.8 0.0 1.9 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOS19485.1 - 3.1e-06 27.3 0.0 5.2e-05 23.3 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Cdh1_DBD_1 PF18196.1 KOS19485.1 - 8.1e-06 26.2 0.4 8.1e-06 26.2 0.4 4.4 2 1 1 3 3 3 1 Chromodomain helicase DNA-binding domain 1 SLIDE PF09111.10 KOS19485.1 - 0.00054 20.0 1.4 0.0039 17.2 0.0 3.0 2 0 0 2 2 2 1 SLIDE CDH1_2_SANT_HL1 PF18375.1 KOS19485.1 - 0.016 15.8 1.2 0.016 15.8 1.2 2.8 2 0 0 2 2 1 0 CDH1/2 SANT-Helical linker 1 AAA_22 PF13401.6 KOS19485.1 - 0.036 14.3 0.0 0.13 12.5 0.0 2.0 1 0 0 1 1 1 0 AAA domain S4 PF01479.25 KOS19485.1 - 0.18 11.6 1.4 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 S4 domain CHDCT2 PF08074.11 KOS19485.1 - 0.21 11.8 4.8 0.24 11.6 0.0 3.1 3 0 0 3 3 3 0 CHDCT2 (NUC038) domain Inositol_P PF00459.25 KOS19486.1 - 1.9e-40 139.1 0.2 2.8e-39 135.3 0.2 2.1 1 1 0 1 1 1 1 Inositol monophosphatase family AAA PF00004.29 KOS19487.1 - 2.1e-56 190.0 0.0 3.2e-43 147.3 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 KOS19487.1 - 3.9e-28 97.7 0.3 9.7e-28 96.4 0.3 1.7 1 0 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 KOS19487.1 - 7.1e-13 48.1 0.5 1e-08 34.8 0.1 2.7 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 KOS19487.1 - 8.3e-12 45.8 5.9 7.7e-06 26.4 0.3 4.6 2 2 0 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 KOS19487.1 - 1.8e-08 34.7 0.0 0.00047 20.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) NACHT PF05729.12 KOS19487.1 - 3.9e-08 33.4 0.7 2.6e-05 24.2 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_18 PF13238.6 KOS19487.1 - 1e-07 32.5 0.0 0.00041 20.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 KOS19487.1 - 1.5e-06 28.2 0.1 0.003 17.5 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 KOS19487.1 - 2.4e-06 27.2 0.0 8.9e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region RuvB_N PF05496.12 KOS19487.1 - 8.4e-06 25.6 0.0 0.015 15.1 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOS19487.1 - 8.8e-06 25.8 0.2 0.039 13.9 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS19487.1 - 1e-05 25.9 2.8 0.015 15.6 0.2 3.7 2 2 1 3 3 3 1 AAA domain AAA_33 PF13671.6 KOS19487.1 - 0.00021 21.5 0.2 0.22 11.7 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_14 PF13173.6 KOS19487.1 - 0.0004 20.4 0.0 0.24 11.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOS19487.1 - 0.00046 19.5 0.1 0.14 11.4 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 KOS19487.1 - 0.00047 19.9 0.1 0.44 10.3 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.13 KOS19487.1 - 0.00053 19.3 0.0 0.99 8.5 0.0 2.3 2 0 0 2 2 2 2 TIP49 P-loop domain Sigma54_activ_2 PF14532.6 KOS19487.1 - 0.001 19.2 0.0 0.029 14.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.22 KOS19487.1 - 0.0016 18.8 0.0 3.1 8.2 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 KOS19487.1 - 0.0019 17.8 2.5 1.4 8.4 0.1 3.5 2 2 1 3 3 3 1 AAA domain Mg_chelatase PF01078.21 KOS19487.1 - 0.0022 17.4 0.1 0.76 9.1 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 KOS19487.1 - 0.0026 18.0 0.1 0.78 10.0 0.1 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 KOS19487.1 - 0.0028 17.4 0.0 0.17 11.6 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain ABC_tran PF00005.27 KOS19487.1 - 0.003 18.1 0.0 0.88 10.1 0.0 2.6 2 0 0 2 2 2 1 ABC transporter SKI PF01202.22 KOS19487.1 - 0.0032 17.6 0.1 0.41 10.8 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase DUF815 PF05673.13 KOS19487.1 - 0.008 15.4 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) APS_kinase PF01583.20 KOS19487.1 - 0.0097 15.8 0.3 0.043 13.7 0.0 2.1 2 0 0 2 2 2 1 Adenylylsulphate kinase PEX-2N PF09263.10 KOS19487.1 - 0.01 16.1 0.7 1.6 9.1 0.0 2.9 3 0 0 3 3 2 0 Peroxisome biogenesis factor 1, N-terminal ATPase PF06745.13 KOS19487.1 - 0.023 14.0 0.0 6 6.1 0.0 2.5 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.22 KOS19487.1 - 0.026 13.7 0.1 5.5 6.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Cytidylate_kin2 PF13189.6 KOS19487.1 - 0.026 14.7 0.0 8.6 6.4 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase-like family PduV-EutP PF10662.9 KOS19487.1 - 0.035 13.8 0.2 0.64 9.8 0.1 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 KOS19487.1 - 0.038 14.4 0.1 2.2 8.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 KOS19487.1 - 0.04 13.8 0.0 9 6.2 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOS19487.1 - 0.1 12.3 0.2 18 4.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 KOS19487.1 - 0.12 12.2 0.2 1.9 8.4 0.1 2.4 2 0 0 2 2 2 0 NTPase ATPase_2 PF01637.18 KOS19487.1 - 0.13 12.2 0.5 5.6 6.8 0.0 2.9 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea DUF4110 PF13422.6 KOS19489.1 - 3.6e-31 107.1 1.4 3.6e-31 107.1 1.4 3.0 3 1 0 3 3 2 1 Domain of unknown function (DUF4110) Kelch_4 PF13418.6 KOS19489.1 - 1.6e-29 101.7 8.2 2.9e-09 36.8 0.0 6.2 6 1 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 KOS19489.1 - 6.1e-26 90.2 13.8 1.5e-08 34.7 0.2 5.4 6 0 0 6 6 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KOS19489.1 - 1.3e-15 57.1 0.8 0.00027 21.1 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 KOS19489.1 - 2.2e-15 56.2 2.8 1.6e-05 24.8 0.0 5.7 6 0 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 KOS19489.1 - 8.1e-12 44.6 6.9 0.00014 21.7 0.1 5.9 6 1 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 KOS19489.1 - 2.1e-10 40.0 5.7 0.00043 19.8 0.1 5.0 5 1 0 5 5 5 2 Kelch motif BUD22 PF09073.10 KOS19489.1 - 0.0026 17.2 14.1 0.0026 17.2 14.1 2.2 2 0 0 2 2 2 1 BUD22 YL1 PF05764.13 KOS19489.1 - 0.0098 16.0 12.9 0.0098 16.0 12.9 3.5 3 1 0 3 3 2 1 YL1 nuclear protein CENP-B_dimeris PF09026.10 KOS19489.1 - 6 7.3 34.4 2.6 8.5 4.1 3.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PI3K_1B_p101 PF10486.9 KOS19489.1 - 6.1 4.5 5.1 9 3.9 4.0 1.7 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit 14-3-3 PF00244.20 KOS19490.1 - 7.9e-106 352.5 4.2 9.4e-106 352.3 4.2 1.1 1 0 0 1 1 1 1 14-3-3 protein SIKE PF05769.11 KOS19490.1 - 0.41 10.6 9.5 2.6 8.0 1.2 3.0 3 0 0 3 3 3 0 SIKE family zf-CSL PF05207.13 KOS19491.1 - 6.8e-16 57.7 0.3 1.6e-15 56.5 0.3 1.7 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 KOS19491.1 - 2.7e-10 40.2 0.1 4.6e-06 26.7 0.1 2.3 2 0 0 2 2 2 2 DnaJ domain DUF1180 PF06679.12 KOS19491.1 - 3.4 8.0 5.6 5.6 7.4 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Nsp1_C PF05064.13 KOS19492.1 - 6e-37 126.0 4.9 6e-37 126.0 4.9 2.2 3 0 0 3 3 2 1 Nsp1-like C-terminal region FliJ PF02050.16 KOS19492.1 - 0.0087 16.3 3.2 0.0087 16.3 3.2 2.1 2 1 1 3 3 3 1 Flagellar FliJ protein Baculo_PEP_C PF04513.12 KOS19492.1 - 0.01 15.9 0.6 0.46 10.5 0.1 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF948 PF06103.11 KOS19492.1 - 0.011 16.0 1.5 0.097 12.9 0.2 2.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 KOS19492.1 - 0.029 14.4 5.5 1.9 8.6 0.2 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) DUF842 PF05811.13 KOS19492.1 - 0.031 13.9 0.3 1 9.1 0.3 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) ERM PF00769.19 KOS19492.1 - 0.032 14.0 8.9 0.045 13.6 8.9 1.3 1 1 0 1 1 1 0 Ezrin/radixin/moesin family V-SNARE PF05008.15 KOS19492.1 - 0.036 14.5 10.0 0.35 11.3 1.2 3.3 3 0 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus PI_PP_I PF18363.1 KOS19492.1 - 0.057 13.6 3.8 0.093 12.9 0.7 2.2 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Laminin_II PF06009.12 KOS19492.1 - 0.062 13.3 8.4 0.93 9.5 0.7 3.0 2 2 0 2 2 2 0 Laminin Domain II NPV_P10 PF05531.12 KOS19492.1 - 0.089 13.3 4.1 2.2 8.8 0.4 3.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF3567 PF12091.8 KOS19492.1 - 0.11 12.6 0.4 0.34 11.1 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) DUF4407 PF14362.6 KOS19492.1 - 0.18 11.2 4.8 0.33 10.3 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Mer2 PF09074.10 KOS19492.1 - 0.2 11.4 8.8 0.07 12.9 2.0 2.1 1 1 0 2 2 2 0 Mer2 SOGA PF11365.8 KOS19492.1 - 0.35 12.0 6.6 0.73 11.0 2.4 2.9 1 1 2 3 3 3 0 Protein SOGA MAS20 PF02064.15 KOS19492.1 - 0.38 10.9 3.9 0.6 10.2 3.4 1.7 1 1 0 1 1 1 0 MAS20 protein import receptor MIP-T3_C PF17749.1 KOS19492.1 - 0.48 10.4 0.1 0.48 10.4 0.1 3.3 2 1 1 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region Sigma70_ner PF04546.13 KOS19492.1 - 0.48 10.3 6.8 4.5 7.1 6.7 2.5 1 1 0 1 1 1 0 Sigma-70, non-essential region APG6_N PF17675.1 KOS19492.1 - 0.59 10.7 15.2 1.2 9.6 6.2 2.3 1 1 0 2 2 2 0 Apg6 coiled-coil region DUF4200 PF13863.6 KOS19492.1 - 0.66 10.4 13.8 1.9 8.9 4.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) WXG100 PF06013.12 KOS19492.1 - 0.66 10.3 11.0 2.7 8.3 2.2 3.5 3 1 1 4 4 4 0 Proteins of 100 residues with WXG OmpH PF03938.14 KOS19492.1 - 0.66 10.3 15.2 1.2 9.5 9.6 2.7 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Rotamase PF00639.21 KOS19492.1 - 0.67 11.0 6.1 4.8 8.2 0.3 2.9 2 2 1 3 3 2 0 PPIC-type PPIASE domain THOC7 PF05615.13 KOS19492.1 - 0.67 10.2 7.4 0.21 11.9 4.6 1.7 2 0 0 2 2 1 0 Tho complex subunit 7 KxDL PF10241.9 KOS19492.1 - 0.7 10.2 8.6 24 5.3 0.1 3.8 2 2 2 4 4 4 0 Uncharacterized conserved protein BRE1 PF08647.11 KOS19492.1 - 1 9.5 12.6 0.43 10.7 2.4 2.6 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase BLOC1_2 PF10046.9 KOS19492.1 - 1.1 9.7 11.1 0.69 10.3 1.2 3.2 2 2 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MerR-DNA-bind PF09278.11 KOS19492.1 - 1.1 9.9 4.9 9.8 6.8 0.1 2.8 3 0 0 3 3 2 0 MerR, DNA binding DUF724 PF05266.14 KOS19492.1 - 1.2 8.9 9.6 2.5 7.9 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Prominin PF05478.11 KOS19492.1 - 2 6.3 5.5 1.9 6.4 0.6 2.1 2 0 0 2 2 2 0 Prominin Syntaxin-6_N PF09177.11 KOS19492.1 - 2 9.0 9.2 2.1 9.0 2.5 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal FapA PF03961.13 KOS19492.1 - 3.3 6.2 6.6 2.2 6.8 4.1 1.7 1 1 2 3 3 3 0 Flagellar Assembly Protein A Prefoldin_2 PF01920.20 KOS19492.1 - 4.2 7.4 13.7 0.39 10.7 0.9 3.4 4 1 0 4 4 4 0 Prefoldin subunit DUF745 PF05335.13 KOS19492.1 - 4.3 7.0 9.1 3.1 7.5 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF2203 PF09969.9 KOS19492.1 - 4.7 8.0 6.8 12 6.6 0.3 2.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FlaC_arch PF05377.11 KOS19492.1 - 5.7 7.4 7.7 4 7.9 0.1 3.2 4 0 0 4 4 3 0 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 KOS19492.1 - 8 5.7 13.8 2.5 7.3 4.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) IATP PF04568.12 KOS19493.1 - 1.8e-26 92.4 10.6 1.1e-25 89.9 10.6 1.9 1 1 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP XhlA PF10779.9 KOS19493.1 - 0.039 14.2 1.4 0.063 13.5 1.4 1.3 1 0 0 1 1 1 0 Haemolysin XhlA tRNA-synt_1 PF00133.22 KOS19494.1 - 7.4e-224 744.5 0.1 1.5e-222 740.1 0.1 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOS19494.1 - 6.1e-35 120.4 3.4 2.4e-34 118.5 3.4 2.1 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOS19494.1 - 1.4e-13 50.4 0.4 5.7e-06 25.3 0.0 4.2 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 KOS19494.1 - 6.7e-12 45.3 5.2 6.3e-10 38.9 0.0 3.0 2 1 1 3 3 3 2 Leucyl-tRNA synthetase, Domain 2 Val_tRNA-synt_C PF10458.9 KOS19494.1 - 5.5e-05 23.4 10.2 5.5e-05 23.4 10.2 3.0 2 1 0 2 2 2 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 KOS19494.1 - 0.13 11.5 0.8 0.77 9.0 0.0 2.5 3 1 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain DUF4407 PF14362.6 KOS19494.1 - 2.9 7.1 12.8 7.6 5.8 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Mitoc_mL59 PF18126.1 KOS19496.1 - 4.5e-43 146.6 2.5 5.2e-43 146.4 2.5 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 DEAD PF00270.29 KOS19497.1 - 1.3e-46 158.6 0.0 2.9e-46 157.5 0.0 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS19497.1 - 1.2e-27 96.4 0.0 1.4e-26 93.0 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS19497.1 - 0.00074 19.6 0.0 0.0018 18.3 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2986 PF11661.8 KOS19497.1 - 0.0011 19.4 1.3 0.0011 19.4 1.3 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2986) PRAI PF00697.22 KOS19497.1 - 0.081 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase eIF2_C PF09173.11 KOS19498.1 - 2.7e-34 117.3 0.5 6.1e-34 116.1 0.5 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 KOS19498.1 - 7.3e-23 81.1 0.8 4.3e-22 78.6 0.8 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KOS19498.1 - 1.1e-09 38.5 0.2 2.2e-09 37.5 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1_Xtn PF16897.5 KOS19498.1 - 0.0047 16.9 0.7 0.017 15.1 0.1 2.0 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 KOS19498.1 - 0.0052 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS19498.1 - 0.025 14.5 0.2 0.23 11.4 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase DUF5102 PF17104.5 KOS19499.1 - 8.6e-92 308.2 0.3 9.6e-92 308.1 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF5102) RBR PF17208.3 KOS19499.1 - 2.3 9.0 7.8 0.24 12.2 2.7 1.9 2 0 0 2 2 2 0 RNA binding Region Shikimate_dh_N PF08501.11 KOS19500.1 - 1.5e-26 92.5 0.0 2.1e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain DHquinase_I PF01487.15 KOS19500.1 - 5.9e-08 33.2 0.0 9.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Type I 3-dehydroquinase Abhydrolase_3 PF07859.13 KOS19501.1 - 6.3e-20 71.9 0.1 8.9e-20 71.4 0.1 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOS19501.1 - 1.2e-19 70.4 0.0 2.2e-12 46.5 0.0 2.2 2 0 0 2 2 2 2 Steryl acetyl hydrolase COesterase PF00135.28 KOS19501.1 - 0.028 13.3 0.6 0.75 8.6 0.0 2.0 2 0 0 2 2 2 0 Carboxylesterase family CBFD_NFYB_HMF PF00808.23 KOS19502.1 - 6e-13 48.9 0.8 1e-12 48.2 0.8 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOS19502.1 - 0.039 14.3 0.1 0.039 14.3 0.1 2.5 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 TAFII28 PF04719.14 KOS19502.1 - 0.16 12.1 1.3 0.35 11.0 1.3 1.5 1 0 0 1 1 1 0 hTAFII28-like protein conserved region CENP-X PF09415.10 KOS19502.1 - 1.7 9.0 4.9 18 5.8 0.3 2.4 2 0 0 2 2 2 0 CENP-S associating Centromere protein X TMEM208_SND2 PF05620.11 KOS19503.1 - 1e-50 171.8 0.1 1.1e-50 171.7 0.1 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF3605 PF12239.8 KOS19504.1 - 2e-54 184.1 0.0 2.4e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Ras PF00071.22 KOS19506.1 - 6.8e-57 191.6 0.0 8.1e-57 191.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS19506.1 - 3.4e-34 117.6 0.0 4.9e-34 117.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS19506.1 - 1.4e-14 53.9 0.0 1.8e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS19506.1 - 2.6e-07 30.4 0.0 3.8e-07 29.8 0.0 1.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS19506.1 - 8.3e-05 22.7 0.0 0.00013 22.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS19506.1 - 9.8e-05 21.8 0.0 0.00012 21.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 KOS19506.1 - 0.00078 19.9 0.0 0.00098 19.5 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOS19506.1 - 0.088 12.7 0.0 1.5 8.7 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase PI3_PI4_kinase PF00454.27 KOS19507.1 - 2.7e-26 92.9 0.0 1.6e-25 90.4 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 KOS19507.1 - 1.5e-18 66.4 0.3 3.2e-18 65.4 0.3 1.6 1 0 0 1 1 1 1 Yeast phosphatidylinositol-4-OH kinase Pik1 DUF4135 PF13575.6 KOS19507.1 - 0.023 14.0 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) CoA_transf_3 PF02515.17 KOS19507.1 - 0.067 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 CoA-transferase family III Kri1_C PF12936.7 KOS19509.1 - 7.6e-30 102.9 1.0 7.6e-30 102.9 1.0 4.4 5 0 0 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 KOS19509.1 - 3.3e-27 95.0 22.3 3.3e-27 95.0 22.3 5.7 5 2 0 5 5 5 1 KRI1-like family Peptidase_C50 PF03568.17 KOS19510.1 - 3.7e-161 536.7 0.0 7.2e-161 535.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family C50 CENP-B_dimeris PF09026.10 KOS19510.1 - 0.00017 21.9 1.6 0.0077 16.6 1.5 2.5 2 0 0 2 2 2 1 Centromere protein B dimerisation domain CHAT PF12770.7 KOS19510.1 - 0.0049 16.3 0.0 0.11 11.9 0.0 2.5 1 1 0 1 1 1 1 CHAT domain RPN7 PF10602.9 KOS19510.1 - 0.021 14.5 2.8 2.3 7.9 0.2 3.6 3 1 1 4 4 4 0 26S proteasome subunit RPN7 TPR_2 PF07719.17 KOS19510.1 - 0.067 13.3 0.4 21 5.6 0.0 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat IMUP PF15761.5 KOS19510.1 - 2.6 8.8 6.7 10 6.8 6.7 2.0 1 0 0 1 1 1 0 Immortalisation up-regulated protein Glyco_hydro_7 PF00840.20 KOS19511.1 - 4.1e-189 628.8 18.3 5.1e-189 628.5 18.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 7 CBM_1 PF00734.18 KOS19511.1 - 5.9e-13 48.5 11.5 5.9e-13 48.5 11.5 4.2 4 0 0 4 4 4 2 Fungal cellulose binding domain NmrA PF05368.13 KOS19512.1 - 9.1e-12 45.0 0.0 8.9e-10 38.5 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_10 PF13460.6 KOS19512.1 - 0.19 11.6 0.0 1.1 9.1 0.0 2.0 1 1 0 1 1 1 0 NAD(P)H-binding GATase PF00117.28 KOS19513.1 - 4.5e-36 124.4 0.0 1.5e-35 122.7 0.0 1.8 2 0 0 2 2 2 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 KOS19513.1 - 4.9e-24 84.2 0.0 4.4e-22 77.9 0.0 2.6 1 1 0 1 1 1 1 GMP synthase C terminal domain Peptidase_C26 PF07722.13 KOS19513.1 - 6.6e-09 35.8 0.0 1.5e-08 34.7 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 NAD_synthase PF02540.17 KOS19513.1 - 2.3e-07 30.2 0.0 1.6e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 NAD synthase tRNA_Me_trans PF03054.16 KOS19513.1 - 0.0036 16.2 0.1 0.0059 15.4 0.1 1.3 1 0 0 1 1 1 1 tRNA methyl transferase ThiI PF02568.14 KOS19513.1 - 0.009 15.6 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 KOS19513.1 - 0.02 14.9 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Arginosuc_synth PF00764.19 KOS19513.1 - 0.045 13.1 0.1 0.067 12.5 0.1 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase QueC PF06508.13 KOS19513.1 - 0.094 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC ATP_bind_3 PF01171.20 KOS19513.1 - 0.12 12.1 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 PP-loop family Fungal_trans_2 PF11951.8 KOS19515.1 - 4e-48 164.2 4.1 5.9e-48 163.6 4.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS19515.1 - 1.6e-06 28.1 5.9 2.8e-06 27.4 5.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NAD_binding_4 PF07993.12 KOS19516.1 - 4.5e-18 65.4 0.0 5.3e-18 65.1 0.0 1.1 1 0 0 1 1 1 1 Male sterility protein ketoacyl-synt PF00109.26 KOS19517.1 - 2.7e-49 168.1 0.0 8.1e-49 166.5 0.0 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 KOS19517.1 - 1.1e-40 140.1 0.0 4e-40 138.3 0.0 1.8 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 KOS19517.1 - 1.7e-31 108.6 0.1 4e-31 107.5 0.1 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain SAT PF16073.5 KOS19517.1 - 4.8e-22 78.9 8.5 7.8e-11 42.2 0.2 4.0 2 1 2 4 4 4 3 Starter unit:ACP transacylase in aflatoxin biosynthesis PS-DH PF14765.6 KOS19517.1 - 8e-07 28.6 0.0 1.4e-06 27.8 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 KOS19517.1 - 0.00011 21.6 0.0 0.00021 20.7 0.0 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Ferritin_2 PF13668.6 KOS19518.1 - 8.7e-06 26.0 0.0 1.3e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain Fungal_trans PF04082.18 KOS19519.1 - 2.4e-20 72.7 0.1 3.8e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain CoaE PF01121.20 KOS19520.1 - 3.7e-42 144.0 0.0 8.7e-42 142.8 0.0 1.6 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 KOS19520.1 - 0.0064 17.0 0.4 0.048 14.2 0.4 2.3 1 1 0 1 1 1 1 AAA domain Transferase PF02458.15 KOS19521.1 - 0.063 11.9 0.0 1 7.9 0.0 2.3 3 0 0 3 3 3 0 Transferase family PAC3 PF10178.9 KOS19522.1 - 1.1e-05 25.4 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 Trp_DMAT PF11991.8 KOS19523.1 - 1.9e-74 251.3 0.0 2.3e-74 251.0 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase TPR_9 PF13371.6 KOS19526.1 - 0.089 12.9 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat 3Beta_HSD PF01073.19 KOS19528.1 - 3.9e-38 131.1 0.0 4.8e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOS19528.1 - 9.1e-23 81.0 0.0 1.2e-22 80.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 KOS19528.1 - 1.2e-10 41.0 0.0 3.3e-08 33.0 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 KOS19528.1 - 6.9e-10 38.8 0.0 2.1e-09 37.2 0.0 1.7 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 KOS19528.1 - 1.7e-06 28.0 0.0 2.4e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding RmlD_sub_bind PF04321.17 KOS19528.1 - 7.6e-06 25.2 0.0 1.2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 KOS19528.1 - 0.00017 20.8 0.0 0.00031 20.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein GST_C_2 PF13410.6 KOS19529.1 - 1.3e-14 54.0 0.0 2.8e-14 52.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOS19529.1 - 3.2e-14 53.0 0.0 5.5e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOS19529.1 - 7.3e-05 22.9 0.0 0.0002 21.5 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS19529.1 - 0.00017 21.7 0.0 0.00031 20.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 KOS19529.1 - 0.076 12.8 0.0 0.19 11.5 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Dala_Dala_lig_C PF07478.13 KOS19530.1 - 2.8e-18 66.2 0.0 2e-08 34.0 0.0 2.1 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 KOS19530.1 - 0.0027 17.8 0.0 0.0094 16.0 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.6 KOS19530.1 - 0.0043 16.7 0.0 0.02 14.5 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain Cupin_8 PF13621.6 KOS19531.1 - 3e-30 105.8 0.0 3.6e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 KOS19531.1 - 8.6e-05 22.1 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein DAO PF01266.24 KOS19532.1 - 3.8e-49 168.2 1.9 1.7e-27 96.9 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase DAO_C PF16901.5 KOS19532.1 - 1e-42 145.0 0.0 1.7e-42 144.3 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_oxidored PF12831.7 KOS19532.1 - 2.1e-06 27.4 0.5 6.6e-06 25.7 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS19532.1 - 5.5e-05 22.4 0.5 0.00011 21.4 0.5 1.5 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOS19532.1 - 0.00092 19.4 0.9 0.0024 18.1 0.5 2.0 2 0 0 2 2 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS19532.1 - 0.0026 17.0 0.1 0.0045 16.3 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOS19532.1 - 0.027 13.6 0.1 0.081 12.0 0.1 1.7 2 0 0 2 2 2 0 Glucose inhibited division protein A HI0933_like PF03486.14 KOS19532.1 - 0.032 12.9 1.1 0.048 12.4 1.1 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 KOS19532.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS19532.1 - 0.067 13.8 0.4 0.25 11.9 0.6 1.8 2 0 0 2 2 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 KOS19532.1 - 0.14 12.0 0.6 0.37 10.7 0.4 1.8 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 KOS19532.1 - 0.24 10.6 1.4 0.71 9.0 0.8 2.0 2 0 0 2 2 2 0 FAD binding domain RGS PF00615.19 KOS19533.1 - 2.3e-06 27.9 0.0 3.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Peptidase_C48 PF02902.19 KOS19534.1 - 7e-13 48.9 0.0 1.6e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Med15 PF09606.10 KOS19534.1 - 0.0012 17.7 13.7 0.0017 17.2 13.7 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Phe_hydrox_dim PF07976.12 KOS19535.1 - 5.7e-40 137.1 0.0 8.9e-40 136.4 0.0 1.3 1 0 0 1 1 1 1 Phenol hydroxylase, C-terminal dimerisation domain FAD_binding_3 PF01494.19 KOS19535.1 - 1.5e-32 113.2 0.0 2.3e-32 112.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain MFS_1 PF07690.16 KOS19538.1 - 6.7e-35 120.6 63.5 1.8e-23 83.0 34.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SASRP1 PF15160.6 KOS19538.1 - 0.14 11.8 0.2 0.22 11.2 0.2 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 TRI12 PF06609.13 KOS19538.1 - 1 7.7 11.9 0.53 8.6 3.2 2.1 2 0 0 2 2 2 0 Fungal trichothecene efflux pump (TRI12) ATP-synt_G PF04718.15 KOS19539.1 - 9.7e-34 116.2 0.5 1.4e-33 115.7 0.2 1.4 2 0 0 2 2 2 1 Mitochondrial ATP synthase g subunit SipA_VBS PF17985.1 KOS19539.1 - 0.077 12.9 0.0 0.23 11.4 0.0 1.9 1 0 0 1 1 1 0 SipA vinculin binding site TFIIA PF03153.13 KOS19540.1 - 2.4e-62 212.3 20.9 5.2e-44 151.9 6.6 3.2 2 1 1 3 3 3 3 Transcription factor IIA, alpha/beta subunit DUF3295 PF11702.8 KOS19540.1 - 0.026 13.9 2.0 0.038 13.3 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) BNIP2 PF12496.8 KOS19540.1 - 0.26 11.7 4.9 0.24 11.8 3.1 1.6 1 1 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 ANAPC4_WD40 PF12894.7 KOS19541.1 - 1.8e-16 60.2 5.3 1.8e-05 25.0 0.1 4.4 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS19541.1 - 5.6e-14 52.3 20.9 0.0014 19.4 0.1 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 KOS19541.1 - 6.4e-06 25.3 0.1 0.00097 18.2 0.0 3.5 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOS19541.1 - 1.1e-05 25.4 0.2 0.0019 18.1 0.1 2.7 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Kelch_4 PF13418.6 KOS19542.1 - 1.7e-29 101.5 7.1 2.8e-08 33.6 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 KOS19542.1 - 2.5e-24 84.8 1.6 4.6e-07 29.7 0.0 4.5 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 KOS19542.1 - 6.7e-23 80.1 3.5 5.3e-05 23.3 0.0 5.2 4 1 1 5 5 5 4 Kelch motif Kelch_3 PF13415.6 KOS19542.1 - 3.9e-19 68.5 3.1 3.8e-07 30.2 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_1 PF01344.25 KOS19542.1 - 5.1e-19 67.6 0.2 1.2e-05 24.8 0.0 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 KOS19542.1 - 4.4e-17 61.3 2.5 0.0003 20.7 0.0 4.6 4 0 0 4 4 4 4 Kelch motif BTB PF00651.31 KOS19542.1 - 1.7e-08 34.7 0.0 2.8e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain Phosphoprotein PF00922.17 KOS19543.1 - 0.17 11.5 0.2 0.24 11.0 0.2 1.2 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein EVI2A PF05399.11 KOS19544.1 - 1.7 8.2 5.7 1.4 8.4 4.2 1.7 1 1 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) HIG_1_N PF04588.13 KOS19545.1 - 5.2e-06 26.6 2.7 1.4e-05 25.2 2.7 1.7 1 0 0 1 1 1 1 Hypoxia induced protein conserved region TarH PF02203.15 KOS19545.1 - 0.03 14.2 3.4 0.051 13.5 3.4 1.4 1 0 0 1 1 1 0 Tar ligand binding domain homologue Kelch_1 PF01344.25 KOS19546.1 - 4.4e-39 131.8 20.1 1.2e-09 37.6 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_5 PF13854.6 KOS19546.1 - 1.7e-36 123.6 17.0 2.8e-07 30.4 0.1 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 KOS19546.1 - 3.3e-35 119.7 12.7 2.3e-07 30.9 0.1 6.6 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_4 PF13418.6 KOS19546.1 - 8.8e-35 118.5 13.0 1.4e-06 28.2 0.1 6.3 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_6 PF13964.6 KOS19546.1 - 5.3e-32 109.0 12.4 5.1e-05 23.4 0.0 6.4 5 1 1 6 6 6 6 Kelch motif Kelch_2 PF07646.15 KOS19546.1 - 3.9e-30 102.7 16.5 1.6e-09 37.3 0.2 6.4 6 0 0 6 6 6 6 Kelch motif Dus PF01207.17 KOS19547.1 - 4.1e-42 144.3 0.0 9.9e-31 107.0 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) zf_CCCH_4 PF18345.1 KOS19547.1 - 0.016 15.3 6.6 0.42 10.7 1.3 2.6 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH PF00642.24 KOS19547.1 - 0.46 10.5 8.0 2.2 8.3 0.7 2.8 2 0 0 2 2 2 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Peroxin-13_N PF04088.13 KOS19548.1 - 6e-49 166.1 0.1 9.2e-49 165.5 0.1 1.3 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_2 PF07653.17 KOS19548.1 - 1.6e-12 46.9 0.0 2.7e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOS19548.1 - 3.7e-09 36.3 0.2 9.2e-09 35.0 0.1 1.7 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 KOS19548.1 - 1e-08 34.6 0.0 1.7e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_3 PF08239.11 KOS19548.1 - 0.045 14.0 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain Med10 PF09748.9 KOS19548.1 - 0.092 12.7 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Transcription factor subunit Med10 of Mediator complex hSH3 PF14603.6 KOS19548.1 - 0.19 12.2 0.0 0.31 11.5 0.0 1.3 1 0 0 1 1 1 0 Helically-extended SH3 domain ADK PF00406.22 KOS19549.1 - 6.4e-44 149.7 0.0 8.5e-44 149.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOS19549.1 - 1.9e-33 115.8 0.0 2.6e-33 115.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOS19549.1 - 1.5e-07 31.7 0.0 4.1e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS19549.1 - 6.2e-07 30.0 0.0 9.8e-07 29.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 KOS19549.1 - 0.021 14.5 0.0 1.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Thymidylate kinase Zeta_toxin PF06414.12 KOS19549.1 - 0.14 11.4 1.0 0.35 10.1 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin DUF3818 PF12825.7 KOS19550.1 - 1.2e-127 425.7 5.3 1.9e-127 425.0 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 KOS19550.1 - 1.4e-38 131.8 1.1 3e-38 130.8 1.1 1.6 1 0 0 1 1 1 1 PX-associated PX PF00787.24 KOS19550.1 - 0.0058 16.6 1.8 0.0084 16.1 0.3 2.1 2 0 0 2 2 2 1 PX domain GFD1 PF17331.2 KOS19550.1 - 0.21 11.8 2.4 0.71 10.1 2.4 2.0 1 0 0 1 1 1 0 GFD1 mRNA transport factor Pkinase PF00069.25 KOS19551.1 - 2.1e-75 253.5 0.0 2.7e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19551.1 - 1.7e-36 125.8 0.0 2.2e-36 125.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 KOS19551.1 - 1.2e-14 54.3 0.1 2.4e-14 53.4 0.1 1.5 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOS19551.1 - 3.3e-08 33.7 0.0 7.9e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 KOS19551.1 - 7.2e-08 32.1 0.0 1.1e-06 28.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 KOS19551.1 - 3.6e-07 29.3 0.0 6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 KOS19551.1 - 0.003 16.9 0.2 0.0051 16.2 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 KOS19551.1 - 0.027 14.0 0.1 0.073 12.6 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 KOS19551.1 - 0.097 12.3 0.3 6.1 6.4 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 KOS19551.1 - 0.14 11.1 0.1 0.26 10.2 0.1 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase PCI PF01399.27 KOS19552.1 - 9.5e-14 51.8 0.0 4.5e-13 49.6 0.0 2.2 2 0 0 2 2 2 1 PCI domain eIF3m_C_helix PF18005.1 KOS19552.1 - 8.9e-12 44.5 2.7 1.6e-11 43.7 0.5 2.4 2 0 0 2 2 2 1 eIF3 subunit M, C-terminal helix DUF883 PF05957.13 KOS19553.1 - 0.0038 17.8 0.3 0.013 16.1 0.0 1.9 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF883) FA_desaturase PF00487.24 KOS19553.1 - 0.052 13.4 2.0 0.066 13.0 2.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase DUF4187 PF13821.6 KOS19554.1 - 3.7e-21 74.7 0.6 1.1e-20 73.1 0.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 KOS19554.1 - 0.002 18.0 14.4 0.0098 15.8 14.4 2.0 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOS19554.1 - 0.28 11.3 6.3 0.88 9.7 6.3 1.9 1 0 0 1 1 1 0 G-patch domain SlyX PF04102.12 KOS19555.1 - 0.00023 21.7 6.5 0.01 16.4 2.0 2.7 2 0 0 2 2 2 1 SlyX ZapB PF06005.12 KOS19555.1 - 0.00077 19.9 7.2 0.079 13.4 4.0 2.3 1 1 1 2 2 2 2 Cell division protein ZapB WASH_WAHD PF11945.8 KOS19555.1 - 0.01 15.4 0.9 0.022 14.3 0.9 1.5 1 0 0 1 1 1 0 WAHD domain of WASH complex MCU PF04678.13 KOS19555.1 - 0.012 15.7 2.8 0.033 14.3 2.8 1.7 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Peptidase_S64 PF08192.11 KOS19555.1 - 0.028 12.9 0.1 0.036 12.6 0.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF2383 PF09537.10 KOS19555.1 - 0.069 13.5 1.1 0.15 12.4 0.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF2383) GAT PF03127.14 KOS19555.1 - 0.073 13.4 0.5 2.8 8.3 0.1 2.4 2 0 0 2 2 2 0 GAT domain DivIC PF04977.15 KOS19555.1 - 0.082 12.7 1.9 0.26 11.1 0.2 2.3 2 0 0 2 2 2 0 Septum formation initiator Prefoldin_2 PF01920.20 KOS19555.1 - 0.12 12.4 2.4 1.2 9.1 2.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF2207 PF09972.9 KOS19555.1 - 0.12 11.1 0.1 0.24 10.1 0.1 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Fib_alpha PF08702.10 KOS19555.1 - 0.13 12.5 1.3 0.21 11.8 1.3 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DASH_Dam1 PF08653.10 KOS19555.1 - 0.14 12.0 0.3 1 9.2 0.1 2.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 Spc7 PF08317.11 KOS19555.1 - 0.16 10.8 5.1 0.24 10.3 5.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 KOS19555.1 - 0.29 11.1 5.6 0.85 9.6 4.9 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FUSC PF04632.12 KOS19555.1 - 0.31 9.5 3.0 0.39 9.2 3.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DHR10 PF18595.1 KOS19555.1 - 0.31 11.1 11.2 0.86 9.7 11.2 1.7 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF1664 PF07889.12 KOS19555.1 - 0.69 10.0 3.4 6.5 6.8 3.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Prominin PF05478.11 KOS19555.1 - 0.72 7.7 4.2 2.9 5.8 1.2 1.9 1 1 1 2 2 2 0 Prominin EMP24_GP25L PF01105.24 KOS19555.1 - 1.7 8.5 8.0 2.9 7.8 4.2 2.3 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD CENP-Q PF13094.6 KOS19555.1 - 2.6 8.2 10.3 6.8 6.9 2.7 2.5 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit FliJ PF02050.16 KOS19555.1 - 3.4 7.9 11.3 5.2 7.3 9.3 2.0 1 1 1 2 2 2 0 Flagellar FliJ protein ABC_tran_Xtn PF12848.7 KOS19555.1 - 7.1 6.7 7.3 3.4 7.7 4.7 1.8 2 0 0 2 2 2 0 ABC transporter Cgr1 PF03879.14 KOS19556.1 - 2.7e-31 108.1 32.7 3.2e-31 107.9 32.7 1.1 1 0 0 1 1 1 1 Cgr1 family RR_TM4-6 PF06459.12 KOS19556.1 - 1.7 8.4 15.4 1.7 8.4 15.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Prismane PF03063.20 KOS19556.1 - 1.8 7.1 5.2 2 7.0 5.2 1.0 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family CDC27 PF09507.10 KOS19556.1 - 3.3 7.0 22.8 4 6.7 22.8 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 C2 PF00168.30 KOS19557.1 - 7.2e-17 61.6 0.0 1.6e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain Membr_traf_MHD PF10540.9 KOS19557.1 - 5.3e-15 55.9 8.0 1.6e-13 51.1 0.3 4.0 4 1 0 4 4 4 1 Munc13 (mammalian uncoordinated) homology domain DUF810 PF05664.11 KOS19557.1 - 3.5e-09 35.8 0.9 3.5e-09 35.8 0.9 1.9 2 0 0 2 2 2 1 Plant family of unknown function (DUF810) SUIM_assoc PF16619.5 KOS19557.1 - 0.085 12.9 12.1 0.02 14.9 7.7 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 KOS19557.1 - 0.15 11.0 8.3 0.25 10.2 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 KOS19557.1 - 0.17 11.5 9.4 0.39 10.3 9.4 1.6 1 0 0 1 1 1 0 Spt20 family TipAS PF07739.13 KOS19557.1 - 0.34 11.5 0.0 0.34 11.5 0.0 4.4 3 1 0 3 3 3 0 TipAS antibiotic-recognition domain DUF5421 PF17458.2 KOS19557.1 - 5.8 6.2 8.9 11 5.3 7.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5421) ArfGap PF01412.18 KOS19558.1 - 9e-31 106.4 0.0 2.5e-30 105.0 0.0 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf BAR_3 PF16746.5 KOS19558.1 - 4.5e-21 75.7 11.6 6.8e-21 75.1 11.6 1.2 1 0 0 1 1 1 1 BAR domain of APPL family PH PF00169.29 KOS19558.1 - 7.5e-12 45.7 0.1 1.8e-11 44.5 0.1 1.7 1 0 0 1 1 1 1 PH domain AAA_assoc PF14363.6 KOS19558.1 - 0.059 13.7 0.7 2.3 8.6 0.8 2.8 2 0 0 2 2 2 0 Domain associated at C-terminal with AAA CRIM PF16978.5 KOS19560.1 - 6.2e-43 146.3 0.0 1.6e-42 145.0 0.0 1.8 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 KOS19560.1 - 3.5e-31 107.7 0.0 7.1e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology RBD PF02196.15 KOS19560.1 - 0.0023 17.9 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 Raf-like Ras-binding domain TUG-UBL1 PF11470.8 KOS19560.1 - 0.0028 17.8 0.0 0.0063 16.7 0.0 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain PH PF00169.29 KOS19560.1 - 0.15 12.6 0.0 7.8 7.1 0.0 2.4 1 1 0 1 1 1 0 PH domain PRCC PF10253.9 KOS19561.1 - 7.3e-30 105.4 8.2 7.3e-30 105.4 8.2 2.5 1 1 1 2 2 2 1 Mitotic checkpoint regulator, MAD2B-interacting Pes-10 PF07149.11 KOS19562.1 - 0.3 10.1 18.2 0.61 9.1 18.2 1.4 1 0 0 1 1 1 0 Pes-10 E1_dh PF00676.20 KOS19563.1 - 9.5e-112 372.8 0.4 1.2e-111 372.5 0.4 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 KOS19563.1 - 0.00091 18.5 0.1 0.0022 17.3 0.1 1.6 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase WD40 PF00400.32 KOS19564.1 - 1.2e-38 130.4 18.7 1.4e-06 28.9 0.1 7.3 8 0 0 8 8 7 6 WD domain, G-beta repeat F-box-like PF12937.7 KOS19564.1 - 1.4e-12 47.3 0.6 2.6e-12 46.4 0.6 1.5 1 0 0 1 1 1 1 F-box-like ANAPC4_WD40 PF12894.7 KOS19564.1 - 5.3e-09 36.3 1.1 0.18 12.1 0.0 5.6 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS19564.1 - 7.1e-09 34.8 6.6 0.035 12.8 0.1 6.0 1 1 5 6 6 6 4 Nucleoporin Nup120/160 F-box PF00646.33 KOS19564.1 - 4.3e-06 26.5 2.1 9.6e-06 25.3 2.1 1.6 1 0 0 1 1 1 1 F-box domain WD40_like PF17005.5 KOS19564.1 - 0.00015 21.2 0.0 0.062 12.6 0.0 3.1 1 1 2 3 3 3 1 WD40-like domain PQQ_2 PF13360.6 KOS19564.1 - 0.0016 18.0 5.2 0.0085 15.7 3.1 2.8 1 1 1 2 2 2 1 PQQ-like domain PQQ_3 PF13570.6 KOS19564.1 - 0.0027 18.1 1.4 3.9 8.1 0.0 4.5 4 0 0 4 4 4 1 PQQ-like domain PALB2_WD40 PF16756.5 KOS19564.1 - 0.0069 15.3 2.7 6.6 5.5 0.0 3.9 2 1 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain EH_Signature PF15611.6 KOS19564.1 - 0.015 14.8 0.0 0.7 9.2 0.0 2.2 2 0 0 2 2 2 0 EH_Signature domain zf_C2HC_14 PF18574.1 KOS19564.1 - 0.11 12.4 1.1 0.64 9.9 0.1 2.3 2 0 0 2 2 2 0 C2HC Zing finger domain F-box_5 PF18511.1 KOS19564.1 - 0.12 12.0 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 F-box Zip PF02535.22 KOS19565.1 - 3.9e-30 105.2 12.6 4.7e-24 85.2 5.7 3.1 3 0 0 3 3 3 3 ZIP Zinc transporter BRF1 PF07741.13 KOS19566.1 - 0.37 11.1 7.6 0.68 10.3 7.6 1.4 1 0 0 1 1 1 0 Brf1-like TBP-binding domain Dyp_perox PF04261.12 KOS19567.1 - 5.4e-77 259.0 0.0 6.1e-77 258.8 0.0 1.0 1 0 0 1 1 1 1 Dyp-type peroxidase family Lipoxygenase PF00305.19 KOS19568.1 - 6.1e-44 150.5 1.2 5e-41 140.9 1.1 2.0 2 0 0 2 2 2 2 Lipoxygenase NADH-u_ox-rdase PF10785.9 KOS19569.1 - 2.4e-29 101.9 0.2 4.1e-29 101.1 0.2 1.4 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit NADH_u_ox_C PF12853.7 KOS19569.1 - 4.6e-25 87.4 0.0 6.4e-25 87.0 0.0 1.2 1 0 0 1 1 1 1 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit GMC_oxred_N PF00732.19 KOS19570.1 - 3.9e-09 36.3 0.0 7.4e-09 35.4 0.0 1.4 1 1 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS19571.1 - 1.7e-05 25.4 0.1 0.00019 22.0 0.1 2.4 2 0 0 2 2 2 1 GMC oxidoreductase Abhydrolase_6 PF12697.7 KOS19571.1 - 0.002 18.8 0.4 0.0092 16.6 0.1 2.3 2 1 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS19571.1 - 0.004 16.5 0.0 2.7 7.2 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Sdh_cyt PF01127.22 KOS19571.1 - 0.007 16.4 0.6 0.014 15.4 0.6 1.4 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Snf7 PF03357.21 KOS19573.1 - 7.1e-08 32.2 21.1 7.8e-08 32.1 20.6 1.4 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 KOS19573.1 - 0.0012 18.8 6.7 0.0021 18.0 6.7 1.6 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway ASL_C PF08328.11 KOS19573.1 - 0.097 12.8 5.4 0.083 13.0 2.7 2.1 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminal CEL_III_C PF18054.1 KOS19573.1 - 1.5 8.9 5.7 0.91 9.6 3.2 1.7 1 1 1 2 2 2 0 CEL-III C-terminal NTP_transf_9 PF04248.12 KOS19574.1 - 4.2e-33 113.1 0.1 5.5e-33 112.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF427) Xan_ur_permease PF00860.20 KOS19575.1 - 9.2e-30 103.6 33.3 9.5e-19 67.3 11.5 3.6 3 1 1 4 4 4 3 Permease family DUF5413 PF17434.2 KOS19575.1 - 3.9 7.8 11.7 0.048 14.0 2.4 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5413) Myc_target_1 PF15179.6 KOS19575.1 - 8.8 6.2 6.1 8.6 6.2 2.1 2.2 2 0 0 2 2 2 0 Myc target protein 1 2OG-FeII_Oxy PF03171.20 KOS19576.1 - 0.00051 20.5 0.0 0.00084 19.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOS19576.1 - 0.0034 18.1 0.0 0.007 17.1 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal PGP_phosphatase PF09419.10 KOS19578.1 - 3.1e-63 212.4 0.0 3.6e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 KOS19578.1 - 0.00019 21.4 0.2 0.00035 20.6 0.2 1.7 1 1 0 1 1 1 1 HAD-hyrolase-like SfsA PF03749.13 KOS19578.1 - 0.021 14.7 0.0 0.13 12.1 0.0 1.9 1 1 0 1 1 1 0 Sugar fermentation stimulation protein RE domain Glyco_hydro_16 PF00722.21 KOS19579.1 - 1.7e-06 27.6 0.0 2.6e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Tim17 PF02466.19 KOS19580.1 - 1.1e-40 138.5 8.1 1.5e-40 138.0 8.1 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF543 PF04418.12 KOS19580.1 - 0.052 13.5 1.2 0.32 11.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF543) ORC2 PF04084.14 KOS19583.1 - 7.6e-120 399.8 0.0 9.4e-120 399.5 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 DUF3619 PF12279.8 KOS19584.1 - 0.1 12.9 5.1 0.27 11.5 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3619) DUF1754 PF08555.10 KOS19585.1 - 2e-13 50.9 19.3 3.4e-13 50.2 19.3 1.4 1 0 0 1 1 1 1 Eukaryotic family of unknown function (DUF1754) Nucleo_P87 PF07267.11 KOS19585.1 - 0.02 13.8 10.2 0.021 13.7 10.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC27 PF09507.10 KOS19585.1 - 0.024 14.0 15.9 0.029 13.8 15.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Myc_N PF01056.18 KOS19585.1 - 0.096 12.6 5.6 0.11 12.4 5.6 1.1 1 0 0 1 1 1 0 Myc amino-terminal region FAM176 PF14851.6 KOS19585.1 - 0.096 12.3 6.2 0.14 11.8 6.2 1.3 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 KOS19585.1 - 0.097 10.7 4.7 0.1 10.7 4.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 KOS19585.1 - 0.13 10.8 6.1 0.16 10.5 6.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Prothymosin PF03247.14 KOS19585.1 - 0.3 11.5 22.2 0.049 14.1 18.3 1.6 2 0 0 2 2 2 0 Prothymosin/parathymosin family UBN_AB PF14075.6 KOS19585.1 - 0.42 10.3 10.9 0.49 10.1 10.9 1.0 1 0 0 1 1 1 0 Ubinuclein conserved middle domain Astro_capsid_p PF12226.8 KOS19585.1 - 0.73 8.9 7.5 0.89 8.6 7.5 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2201_N PF13203.6 KOS19585.1 - 0.74 9.4 7.6 0.87 9.1 7.6 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain DNA_pol_phi PF04931.13 KOS19585.1 - 1.5 6.8 10.3 1.8 6.6 10.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.12 KOS19585.1 - 1.6 7.7 5.9 1.7 7.6 5.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 KOS19585.1 - 2.2 8.0 11.7 2.6 7.8 11.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 KOS19585.1 - 2.4 7.4 10.1 3 7.1 10.1 1.1 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 KOS19585.1 - 2.5 6.8 8.5 2.6 6.7 8.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 KOS19585.1 - 5.1 7.4 14.3 7.4 6.9 14.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PBP1_TM PF14812.6 KOS19585.1 - 6.3 7.2 18.3 0.73 10.2 13.4 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 KOS19585.1 - 6.5 5.9 6.4 7.3 5.7 6.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter AA_permease_2 PF13520.6 KOS19586.1 - 1.1e-62 212.2 37.8 1.5e-62 211.9 37.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS19586.1 - 6.8e-29 100.8 28.0 6.8e-29 100.8 28.0 1.8 2 0 0 2 2 2 1 Amino acid permease DUF382 PF04037.13 KOS19587.1 - 3.5e-35 120.9 13.8 1.5e-29 102.7 1.2 3.5 2 1 1 3 3 3 2 Domain of unknown function (DUF382) PSP PF04046.16 KOS19587.1 - 1.8e-17 62.9 5.1 4e-17 61.8 5.1 1.6 1 0 0 1 1 1 1 PSP Acetyltransf_1 PF00583.25 KOS19588.1 - 1.3e-11 44.7 0.0 1.9e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS19588.1 - 1.6e-07 31.3 0.0 2.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS19588.1 - 4.9e-06 26.9 0.0 9.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS19588.1 - 0.00023 21.1 0.0 0.0004 20.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 KOS19588.1 - 0.0051 17.5 0.0 0.0072 17.0 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOS19588.1 - 0.11 12.6 0.0 0.15 12.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Complex1_LYR PF05347.15 KOS19589.1 - 4.4e-18 65.1 0.3 5.9e-18 64.7 0.3 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOS19589.1 - 1.2e-08 35.5 0.1 1.6e-08 35.2 0.1 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Vps8 PF12816.7 KOS19590.1 - 2.2e-73 246.0 0.0 3.3e-73 245.4 0.0 1.3 1 0 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 KOS19590.1 - 0.00013 21.8 0.0 0.22 11.4 0.0 3.8 4 0 0 4 4 4 2 Region in Clathrin and VPS IMPDH PF00478.25 KOS19591.1 - 2e-127 424.9 2.4 2.4e-127 424.7 2.4 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 KOS19591.1 - 1.8e-14 53.9 0.2 3e-07 30.8 0.1 2.5 2 0 0 2 2 2 2 CBS domain NMO PF03060.15 KOS19591.1 - 3.6e-09 36.4 1.5 0.00067 19.2 2.1 2.4 2 0 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 KOS19591.1 - 1.5e-08 34.1 0.6 6e-07 28.8 0.4 2.2 2 0 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 KOS19591.1 - 0.00015 21.3 1.6 0.027 14.0 0.2 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.14 KOS19591.1 - 0.067 12.5 2.8 0.1 11.9 0.4 2.3 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG DEAD PF00270.29 KOS19592.1 - 1.5e-26 93.2 0.0 2.5e-16 60.0 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS19592.1 - 1.6e-24 86.4 0.0 3.7e-24 85.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS19592.1 - 0.00071 19.6 0.0 0.0022 18.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T4SS-DNA_transf PF02534.14 KOS19592.1 - 0.052 12.3 0.0 0.1 11.4 0.0 1.4 1 0 0 1 1 1 0 Type IV secretory system Conjugative DNA transfer DUF913 PF06025.12 KOS19592.1 - 0.095 11.7 2.0 0.22 10.5 2.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 KOS19592.1 - 0.096 11.0 15.9 0.22 9.8 15.9 1.5 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOS19592.1 - 0.26 10.6 23.4 0.51 9.6 23.4 1.4 1 0 0 1 1 1 0 NOA36 protein SAPS PF04499.15 KOS19592.1 - 0.71 8.6 6.2 1.3 7.7 6.2 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 KOS19592.1 - 0.76 7.9 26.5 0.0095 14.2 18.9 1.5 2 0 0 2 2 2 0 Nop14-like family TRAP_alpha PF03896.16 KOS19592.1 - 0.9 8.7 9.8 2.1 7.5 9.8 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2076 PF09849.9 KOS19592.1 - 1.6 8.7 13.9 0.068 13.2 7.8 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) DNA_pol_phi PF04931.13 KOS19592.1 - 1.7 6.7 31.0 1.7 6.6 29.9 1.5 2 0 0 2 2 2 0 DNA polymerase phi RRN3 PF05327.11 KOS19592.1 - 2.2 6.7 16.8 3.3 6.1 16.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SpoIIIAH PF12685.7 KOS19592.1 - 4.4 7.1 15.2 7.2 6.4 11.5 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein CPSF100_C PF13299.6 KOS19592.1 - 5.8 7.1 9.5 2.1 8.5 4.0 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Mpp10 PF04006.12 KOS19592.1 - 9.6 4.5 25.9 0.14 10.6 17.0 2.1 2 0 0 2 2 2 0 Mpp10 protein PIG-P PF08510.12 KOS19593.1 - 2.3e-52 176.0 0.1 3e-52 175.6 0.1 1.1 1 0 0 1 1 1 1 PIG-P DPM2 PF07297.12 KOS19593.1 - 0.035 14.4 10.2 0.06 13.7 10.2 1.3 1 0 0 1 1 1 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DUF1180 PF06679.12 KOS19593.1 - 0.05 14.0 0.0 0.075 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Phage_holin_3_6 PF07332.11 KOS19593.1 - 0.81 9.7 3.4 1.2 9.2 3.4 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Actin PF00022.19 KOS19594.1 - 2.7e-144 480.8 0.0 3e-144 480.6 0.0 1.0 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOS19594.1 - 4e-06 25.9 0.2 0.027 13.3 0.0 2.6 2 1 1 3 3 3 2 MreB/Mbl protein DUF2401 PF10287.9 KOS19595.1 - 5e-81 271.6 0.0 5.7e-81 271.5 0.0 1.0 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) Raffinose_syn PF05691.12 KOS19596.1 - 2.4e-09 35.6 0.0 3.1e-09 35.2 0.0 1.1 1 0 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 tRNA-synt_2 PF00152.20 KOS19597.1 - 6.5e-62 209.4 0.0 1.5e-50 172.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 KOS19597.1 - 1.5e-06 27.9 0.0 0.0009 18.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA_anti-codon PF01336.25 KOS19597.1 - 0.00023 21.1 0.3 0.00043 20.2 0.3 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain NOA36 PF06524.12 KOS19597.1 - 0.24 10.7 4.7 0.37 10.1 4.7 1.2 1 0 0 1 1 1 0 NOA36 protein Ribosomal_60s PF00428.19 KOS19597.1 - 3.2 8.4 7.9 7.7 7.2 7.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein CENP-B_dimeris PF09026.10 KOS19597.1 - 3.4 8.1 9.7 7 7.1 9.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WD40 PF00400.32 KOS19598.1 - 6.4e-25 86.9 15.6 2.3e-07 31.4 0.3 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19598.1 - 5.5e-05 23.4 1.0 2 8.8 0.1 4.3 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS19598.1 - 0.00076 18.5 0.9 0.025 13.5 0.4 2.9 3 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Ctr PF04145.15 KOS19599.1 - 6.1e-15 56.1 1.0 2e-12 48.0 1.0 2.1 1 1 0 1 1 1 1 Ctr copper transporter family NUDIX PF00293.28 KOS19600.1 - 1.1e-07 31.9 0.0 1.1e-07 31.9 0.0 2.0 2 0 0 2 2 2 1 NUDIX domain Anillin PF08174.11 KOS19601.1 - 0.0022 18.4 13.2 2.3 8.6 0.8 5.1 1 1 5 6 6 6 2 Cell division protein anillin DUF5485 PF17586.2 KOS19601.1 - 0.02 15.2 12.5 77 3.7 0.3 6.0 6 0 0 6 6 6 0 Family of unknown function (DUF5485) EXS PF03124.14 KOS19603.1 - 1.5e-110 369.6 11.7 1.7e-110 369.4 11.7 1.0 1 0 0 1 1 1 1 EXS family Pex2_Pex12 PF04757.14 KOS19604.1 - 1.3e-40 139.4 3.4 1.7e-40 139.0 3.4 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 KOS19604.1 - 3.2e-11 43.4 8.7 4.8e-11 42.8 8.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 KOS19604.1 - 1.7e-10 40.6 6.7 2.6e-10 40.0 6.7 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS19604.1 - 2.8e-10 39.9 8.9 4.2e-10 39.3 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS19604.1 - 2.1e-09 37.1 6.5 3.1e-09 36.5 6.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS19604.1 - 7.8e-08 32.2 6.4 1.6e-07 31.3 6.4 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS19604.1 - 1.6e-07 31.2 5.5 2.5e-07 30.5 5.5 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 KOS19604.1 - 2.6e-07 30.8 6.6 4.8e-07 30.0 6.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOS19604.1 - 3.4e-07 30.0 6.6 5.6e-07 29.3 6.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 KOS19604.1 - 1.5e-06 28.2 7.3 2.5e-06 27.6 7.3 1.3 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 KOS19604.1 - 0.00027 20.8 2.3 0.00053 19.8 2.3 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_10 PF16685.5 KOS19604.1 - 0.00061 19.9 5.1 0.001 19.2 5.1 1.3 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf-Nse PF11789.8 KOS19604.1 - 0.0036 17.1 1.2 0.0064 16.3 1.2 1.3 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 KOS19604.1 - 0.016 15.2 2.9 0.027 14.5 2.9 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 KOS19604.1 - 0.032 14.0 6.9 0.068 13.0 6.9 1.5 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain YdjO PF14169.6 KOS19604.1 - 0.12 12.1 2.8 1.2 8.9 0.3 2.9 3 0 0 3 3 3 0 Cold-inducible protein YdjO zf-RING_11 PF17123.5 KOS19604.1 - 0.21 11.3 2.8 0.52 10.1 2.8 1.7 1 0 0 1 1 1 0 RING-like zinc finger zf-LYAR PF08790.11 KOS19605.1 - 1.2e-13 50.7 2.2 1.2e-13 50.7 2.2 1.9 2 0 0 2 2 2 1 LYAR-type C2HC zinc finger SR-25 PF10500.9 KOS19605.1 - 2.9 7.5 38.6 0.38 10.3 21.3 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF2514 PF10721.9 KOS19605.1 - 3.4 7.7 6.1 9.3 6.3 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) Hydrolase_4 PF12146.8 KOS19606.1 - 1.5e-18 67.0 0.0 5.1e-11 42.3 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS19606.1 - 3.5e-11 43.2 0.1 1.6e-06 27.9 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS19606.1 - 1.9e-05 25.4 0.0 0.00017 22.3 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family DUF818 PF05677.12 KOS19606.1 - 3.2e-05 23.1 0.0 4.8e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) FSH1 PF03959.13 KOS19606.1 - 4.5e-05 23.2 0.0 0.00012 21.8 0.0 1.6 2 0 0 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 KOS19606.1 - 6.4e-05 21.8 0.1 0.22 10.2 0.0 3.1 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) Abhydrolase_2 PF02230.16 KOS19606.1 - 0.00032 20.6 0.0 0.021 14.6 0.0 2.3 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOS19606.1 - 0.0038 16.7 0.0 0.037 13.5 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 KOS19606.1 - 0.017 14.7 0.0 3.1 7.3 0.0 2.4 3 0 0 3 3 3 0 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 KOS19606.1 - 0.062 13.1 0.0 0.67 9.7 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KOS19606.1 - 0.18 11.6 0.1 0.47 10.3 0.1 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold R3H PF01424.22 KOS19607.1 - 3.1e-11 43.1 0.0 5.9e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 KOS19607.1 - 0.0002 21.3 12.5 0.0002 21.3 12.5 14.8 17 2 1 18 18 18 6 NF-X1 type zinc finger WSC PF01822.19 KOS19608.1 - 2.4e-83 274.4 83.6 1e-17 64.1 7.5 5.3 5 0 0 5 5 5 5 WSC domain Glyoxal_oxid_N PF07250.11 KOS19608.1 - 4.1e-26 91.6 0.0 9.3e-26 90.5 0.0 1.6 1 0 0 1 1 1 1 Glyoxal oxidase N-terminus DUF1929 PF09118.11 KOS19608.1 - 2.5e-20 72.6 0.0 5.4e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) GLEYA PF10528.9 KOS19608.1 - 0.071 13.5 0.1 20 5.7 0.0 3.2 3 0 0 3 3 3 0 GLEYA domain AAA_2 PF07724.14 KOS19609.1 - 4.1e-48 163.7 0.2 3.5e-45 154.2 0.0 3.7 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 KOS19609.1 - 1.6e-32 111.5 4.2 1.6e-32 111.5 4.2 3.9 4 0 0 4 4 3 1 AAA lid domain AAA PF00004.29 KOS19609.1 - 4.8e-27 95.0 0.0 6.6e-14 52.5 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 KOS19609.1 - 1.9e-24 85.5 1.8 5e-24 84.2 0.4 2.7 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 KOS19609.1 - 7.7e-16 58.4 0.0 7.5e-10 39.0 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS19609.1 - 2.7e-12 47.2 0.1 5.9e-05 23.4 0.0 4.3 2 1 1 3 3 2 2 AAA domain AAA_16 PF13191.6 KOS19609.1 - 8.2e-12 45.8 12.0 7.8e-07 29.6 0.0 5.1 4 3 3 7 7 5 2 AAA ATPase domain Sigma54_activat PF00158.26 KOS19609.1 - 6.3e-10 39.0 0.0 2.1e-06 27.5 0.0 2.7 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 KOS19609.1 - 1.3e-07 31.3 0.0 0.0073 15.8 0.0 3.4 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_14 PF13173.6 KOS19609.1 - 9.2e-07 29.0 0.1 0.078 13.0 0.0 3.2 3 0 0 3 3 2 2 AAA domain Clp_N PF02861.20 KOS19609.1 - 2.5e-06 27.5 7.7 0.01 15.9 0.2 4.7 4 0 0 4 4 4 2 Clp amino terminal domain, pathogenicity island component AAA_18 PF13238.6 KOS19609.1 - 2.6e-06 28.0 1.1 0.14 12.7 0.0 4.2 3 1 0 3 3 2 2 AAA domain IstB_IS21 PF01695.17 KOS19609.1 - 3.4e-06 26.9 0.0 0.063 13.0 0.0 2.7 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_33 PF13671.6 KOS19609.1 - 1e-05 25.7 0.0 0.25 11.5 0.0 3.3 2 0 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 KOS19609.1 - 1.2e-05 25.3 7.2 0.028 14.4 0.1 4.7 4 1 1 5 5 4 1 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 KOS19609.1 - 1.6e-05 24.4 0.1 0.13 11.6 0.1 3.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOS19609.1 - 3.7e-05 24.1 0.0 0.37 11.2 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 KOS19609.1 - 4.2e-05 23.8 0.6 0.36 11.1 0.0 3.4 3 0 0 3 3 2 2 AAA domain TsaE PF02367.17 KOS19609.1 - 0.00015 21.8 0.0 0.37 10.8 0.0 2.6 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 KOS19609.1 - 0.00016 21.4 1.2 1.1 9.0 0.4 4.3 3 1 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_19 PF13245.6 KOS19609.1 - 0.0002 21.7 0.1 0.14 12.5 0.1 3.8 4 1 0 4 4 3 1 AAA domain ABC_tran PF00005.27 KOS19609.1 - 0.00023 21.7 0.4 0.65 10.5 0.0 3.5 3 0 0 3 3 3 1 ABC transporter RsgA_GTPase PF03193.16 KOS19609.1 - 0.00027 20.9 0.0 0.4 10.6 0.0 3.1 2 1 0 2 2 2 1 RsgA GTPase AAA_3 PF07726.11 KOS19609.1 - 0.00029 20.7 0.1 1.5 8.7 0.0 3.8 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOS19609.1 - 0.00038 20.2 0.0 1.2 8.8 0.0 3.1 2 0 0 2 2 2 2 AAA domain T2SSE PF00437.20 KOS19609.1 - 0.0004 19.5 0.1 0.0041 16.2 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_24 PF13479.6 KOS19609.1 - 0.0005 19.8 1.8 0.45 10.2 0.0 3.2 4 0 0 4 4 2 2 AAA domain Torsin PF06309.11 KOS19609.1 - 0.0013 18.8 0.0 0.0054 16.8 0.0 1.9 2 0 0 2 2 1 1 Torsin NACHT PF05729.12 KOS19609.1 - 0.0018 18.2 0.0 0.24 11.3 0.0 3.0 3 0 0 3 3 2 1 NACHT domain Zeta_toxin PF06414.12 KOS19609.1 - 0.0028 17.0 0.0 0.51 9.6 0.0 3.0 2 0 0 2 2 2 1 Zeta toxin ResIII PF04851.15 KOS19609.1 - 0.0033 17.4 0.2 0.55 10.2 0.0 3.6 4 0 0 4 4 3 1 Type III restriction enzyme, res subunit Roc PF08477.13 KOS19609.1 - 0.0039 17.4 0.0 2.6 8.3 0.0 2.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 KOS19609.1 - 0.005 16.6 0.0 5.5 6.8 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.15 KOS19609.1 - 0.0079 16.1 0.2 4.8 7.1 0.0 3.0 3 1 1 4 4 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 KOS19609.1 - 0.0085 16.0 0.2 0.49 10.3 0.0 3.4 4 0 0 4 4 3 1 NTPase SRP54 PF00448.22 KOS19609.1 - 0.019 14.6 0.0 6.5 6.3 0.0 2.9 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain DUF815 PF05673.13 KOS19609.1 - 0.022 13.9 0.0 3.6 6.7 0.0 3.1 3 1 0 3 3 2 0 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 KOS19609.1 - 0.072 12.9 0.0 9.9 5.9 0.0 2.7 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 KOS19609.1 - 0.083 12.6 0.0 6.9 6.4 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 KOS19609.1 - 0.093 12.3 4.3 2.5 7.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain CbiA PF01656.23 KOS19609.1 - 0.23 11.5 1.1 43 4.2 0.1 3.4 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_23 PF13476.6 KOS19609.1 - 0.37 11.2 0.0 0.37 11.2 0.0 4.7 3 2 0 3 3 2 0 AAA domain THOC7 PF05615.13 KOS19609.1 - 1 9.7 13.2 1.8 8.8 3.0 3.0 2 0 0 2 2 2 0 Tho complex subunit 7 FlaC_arch PF05377.11 KOS19609.1 - 1.4 9.4 3.9 4.9 7.6 0.5 3.1 1 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Cob_adeno_trans PF01923.18 KOS19609.1 - 2.7 8.1 7.2 3.8 7.6 2.5 3.1 3 1 0 3 3 3 0 Cobalamin adenosyltransferase TMF_TATA_bd PF12325.8 KOS19609.1 - 3.3 8.0 12.2 23 5.3 8.5 3.2 2 1 0 2 2 1 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.6 KOS19609.1 - 6.5 6.9 15.0 1.6 8.9 10.0 2.7 2 1 0 2 2 1 0 Centrosome localisation domain of PPC89 Mhr1 PF12829.7 KOS19610.1 - 3.8e-31 107.0 0.0 7.9e-31 106.0 0.0 1.5 2 0 0 2 2 2 1 Transcriptional regulation of mitochondrial recombination Sulfotransfer_3 PF13469.6 KOS19611.1 - 3.1e-07 31.0 0.2 2.9e-06 27.8 0.0 2.4 2 1 0 2 2 2 1 Sulfotransferase family PDT PF00800.18 KOS19612.1 - 8.5e-51 172.4 0.0 1.2e-50 171.9 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 KOS19612.1 - 9.3e-06 25.3 0.0 1.9e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 ACT domain ABM PF03992.16 KOS19613.1 - 0.024 14.7 0.0 0.84 9.8 0.0 2.2 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase JAB PF01398.21 KOS19614.1 - 6.6e-07 29.3 0.7 7.5e-06 25.9 0.7 2.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Peptidase_C31 PF05410.13 KOS19614.1 - 0.073 13.2 0.0 2.1 8.4 0.0 2.4 1 1 1 2 2 2 0 Porcine arterivirus-type cysteine proteinase alpha PIG-X PF08320.12 KOS19615.1 - 8.8e-62 208.7 0.0 1.2e-61 208.3 0.0 1.2 1 0 0 1 1 1 1 PIG-X / PBN1 Zn_clus PF00172.18 KOS19616.1 - 8.2e-08 32.2 7.3 1.8e-07 31.2 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pkinase PF00069.25 KOS19617.1 - 7.5e-68 228.8 0.0 1.3e-67 227.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19617.1 - 1.4e-48 165.5 0.0 2.4e-48 164.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 KOS19617.1 - 7.3e-27 93.6 0.0 1.4e-26 92.8 0.0 1.5 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 KOS19617.1 - 1.9e-15 56.7 0.3 7.2e-15 54.9 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) RA PF00788.23 KOS19617.1 - 3.3e-15 56.5 0.0 7.2e-15 55.4 0.0 1.6 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_1 PF00536.30 KOS19617.1 - 3.8e-15 56.1 0.1 7.3e-15 55.2 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 KOS19617.1 - 1.7e-07 30.8 0.0 0.00025 20.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like SAM_PNT PF02198.16 KOS19617.1 - 0.0075 16.2 0.0 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_4 PF18017.1 KOS19617.1 - 0.0088 16.0 0.1 0.022 14.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pkinase_fungal PF17667.1 KOS19617.1 - 0.02 13.7 0.0 0.038 12.7 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Relaxase PF03432.14 KOS19617.1 - 0.063 12.9 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Relaxase/Mobilisation nuclease domain Asp PF00026.23 KOS19618.1 - 2.2e-68 231.0 0.2 3.2e-68 230.5 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS19618.1 - 3.6e-13 50.2 1.9 6.1e-12 46.1 1.2 2.9 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOS19618.1 - 0.0001 22.9 2.5 0.78 10.4 0.0 4.0 3 2 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 KOS19618.1 - 0.00025 20.9 0.0 0.00046 20.0 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 KOS19618.1 - 0.012 16.1 0.1 1.9 9.1 0.0 3.2 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease Zn_clus PF00172.18 KOS19619.1 - 0.00059 19.9 12.3 0.0012 18.9 12.3 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CHZ PF09649.10 KOS19619.1 - 0.00072 19.0 0.5 0.0053 16.2 0.0 2.4 2 0 0 2 2 2 1 Histone chaperone domain CHZ MFS_1 PF07690.16 KOS19620.1 - 3.5e-29 101.9 47.3 3.5e-29 101.9 47.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2070 PF09843.9 KOS19620.1 - 1.4 7.1 14.7 2.2 6.5 14.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Abhydrolase_6 PF12697.7 KOS19621.1 - 4e-05 24.3 8.1 6.5e-05 23.6 8.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Thioesterase PF00975.20 KOS19621.1 - 0.011 15.8 0.0 0.024 14.8 0.0 1.5 2 0 0 2 2 2 0 Thioesterase domain Hydrolase_4 PF12146.8 KOS19621.1 - 0.033 13.5 0.0 0.061 12.6 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KOS19621.1 - 0.049 13.5 8.5 0.86 9.4 8.5 2.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF3684 PF12449.8 KOS19622.1 - 0 1066.7 1.3 1.5e-209 698.6 0.0 4.7 1 1 4 5 5 5 5 Protein of unknown function (DUF3684) HATPase_c_3 PF13589.6 KOS19622.1 - 0.0002 21.2 0.0 0.00053 19.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fe_dep_repr_C PF02742.15 KOS19622.1 - 0.092 12.8 0.3 0.3 11.2 0.3 1.9 1 0 0 1 1 1 0 Iron dependent repressor, metal binding and dimerisation domain tRNA-synt_1 PF00133.22 KOS19623.1 - 1.7e-49 168.6 0.0 9.3e-18 63.8 0.2 6.1 2 1 3 5 5 5 5 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 KOS19623.1 - 4e-40 137.3 0.0 1.5e-39 135.5 0.0 2.0 2 1 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 KOS19623.1 - 1e-27 96.9 0.2 2.6e-19 69.3 0.0 4.7 4 1 1 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOS19623.1 - 1.7e-10 41.1 0.0 3e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KOS19623.1 - 0.038 13.3 0.0 4.4 6.5 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Zn-ribbon_8 PF09723.10 KOS19623.1 - 0.68 10.1 2.2 1.7 8.8 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 KOS19623.1 - 2.3 7.7 4.7 0.82 9.2 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain PQ-loop PF04193.14 KOS19624.1 - 5.4e-32 109.4 4.2 7.2e-16 57.7 2.0 2.5 2 0 0 2 2 2 2 PQ loop repeat Polysacc_synt_C PF14667.6 KOS19624.1 - 0.054 13.6 1.9 0.15 12.1 1.9 1.8 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain GTA_holin_3TM PF11351.8 KOS19624.1 - 0.18 12.4 2.9 0.77 10.3 0.1 2.6 3 0 0 3 3 3 0 Holin of 3TMs, for gene-transfer release Fun_ATP-synt_8 PF05933.13 KOS19624.1 - 0.29 11.3 2.1 0.4 10.9 0.2 2.2 2 0 0 2 2 2 0 Fungal ATP synthase protein 8 (A6L) Mito_carr PF00153.27 KOS19625.1 - 2.6e-73 242.0 0.4 4.2e-25 87.5 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein EF-hand_1 PF00036.32 KOS19625.1 - 2e-15 55.1 0.1 8.7e-06 24.9 0.0 5.1 5 0 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 KOS19625.1 - 2.1e-15 56.9 1.2 1.7e-07 31.6 0.1 3.4 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 KOS19625.1 - 7.7e-15 53.5 0.1 1.1e-05 25.0 0.0 5.7 7 0 0 7 7 7 2 EF-hand domain EF-hand_5 PF13202.6 KOS19625.1 - 2.2e-11 42.7 0.2 0.00012 21.4 0.1 3.8 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 KOS19625.1 - 7.9e-10 38.4 0.2 0.016 15.1 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain pair Tyrosinase PF00264.20 KOS19626.1 - 2.2e-32 113.2 0.3 3.8e-32 112.4 0.3 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase Tyosinase_C PF18132.1 KOS19626.1 - 4.1e-28 98.5 0.0 1.2e-27 97.0 0.0 1.8 2 0 0 2 2 2 1 Tyosinase C-terminal domain ADC PF06314.11 KOS19627.1 - 0.022 14.3 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 Acetoacetate decarboxylase (ADC) Arf PF00025.21 KOS19628.1 - 4.4e-41 140.2 0.0 5.2e-41 140.0 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 KOS19628.1 - 5.6e-18 65.1 0.0 6.5e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS19628.1 - 8.5e-15 55.0 0.0 1.2e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 KOS19628.1 - 3.1e-06 26.7 0.0 3.8e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS19628.1 - 6.2e-06 26.3 0.0 8.8e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 KOS19628.1 - 9.1e-06 25.1 0.1 2.8e-05 23.4 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit SRPRB PF09439.10 KOS19628.1 - 0.00012 21.6 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 KOS19628.1 - 0.026 14.5 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain FeoB_N PF02421.18 KOS19628.1 - 0.04 13.5 0.1 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS19628.1 - 0.18 11.8 0.1 0.45 10.5 0.1 1.6 1 1 1 2 2 2 0 Dynamin family RNA_pol_Rpb2_6 PF00562.28 KOS19629.1 - 5.5e-112 374.7 0.0 7.2e-112 374.3 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOS19629.1 - 3.8e-33 114.7 0.0 6e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 KOS19629.1 - 5.4e-29 100.2 0.0 1.6e-28 98.7 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 KOS19629.1 - 2.4e-27 95.8 0.0 3.8e-27 95.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpa2_4 PF06883.12 KOS19629.1 - 1e-21 76.6 0.0 2.5e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 KOS19629.1 - 7.1e-16 58.4 0.0 4.8e-14 52.5 0.0 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF570 PF04489.13 KOS19629.1 - 0.034 12.8 0.0 0.052 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF570) Beta_elim_lyase PF01212.21 KOS19630.1 - 6.5e-70 235.7 0.0 7.8e-70 235.5 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 KOS19630.1 - 0.00014 20.5 0.0 0.0004 19.0 0.0 1.7 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOS19630.1 - 0.005 15.8 0.0 0.0073 15.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS19630.1 - 0.0053 16.1 0.0 0.014 14.7 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Glyco_transf_17 PF04724.13 KOS19631.1 - 8.4e-44 150.0 0.0 1.8e-43 149.0 0.0 1.4 1 1 0 1 1 1 1 Glycosyltransferase family 17 DPPIV_N PF00930.21 KOS19632.1 - 3.1e-105 351.8 0.0 3.9e-105 351.5 0.0 1.1 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KOS19632.1 - 4.2e-51 173.4 0.3 9.4e-51 172.3 0.2 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 KOS19632.1 - 0.0057 16.3 0.2 0.018 14.7 0.1 1.8 1 1 0 2 2 2 1 alpha/beta hydrolase fold PD40 PF07676.12 KOS19632.1 - 0.048 13.6 0.3 0.74 9.8 0.1 2.9 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat YbjQ_1 PF01906.17 KOS19633.1 - 7.1e-26 90.9 0.0 8.2e-26 90.7 0.0 1.0 1 0 0 1 1 1 1 Putative heavy-metal-binding MFS_1 PF07690.16 KOS19634.1 - 1.6e-36 125.9 39.7 1.6e-36 125.9 39.7 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS19634.1 - 6.4e-11 41.8 8.4 6.4e-11 41.8 8.4 2.8 2 2 0 2 2 2 1 Sugar (and other) transporter Clathrin PF00637.20 KOS19635.1 - 7.1e-200 654.9 40.3 7.6e-32 110.2 0.6 7.3 7 0 0 7 7 7 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 KOS19635.1 - 9.5e-32 108.7 2.7 1.1e-31 108.5 0.1 2.7 3 0 0 3 3 3 1 Clathrin-H-link Clathrin_propel PF01394.20 KOS19635.1 - 4.5e-30 102.5 0.5 8.1e-06 25.9 0.1 6.7 6 0 0 6 6 6 6 Clathrin propeller repeat TPR_14 PF13428.6 KOS19635.1 - 0.0016 19.1 6.1 31 5.7 0.0 7.6 7 0 0 7 7 7 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 KOS19635.1 - 0.0095 15.0 9.2 0.55 9.2 0.4 4.5 5 0 0 5 5 5 2 Coatomer WD associated region TPR_7 PF13176.6 KOS19635.1 - 0.027 14.5 10.6 7 6.9 0.1 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat 6PF2K PF01591.18 KOS19635.1 - 0.029 13.7 0.2 0.089 12.1 0.2 1.8 1 0 0 1 1 1 0 6-phosphofructo-2-kinase RPAP3_C PF13877.6 KOS19635.1 - 0.062 13.8 1.0 48 4.6 0.0 4.0 3 0 0 3 3 3 0 Potential Monad-binding region of RPAP3 Clathrin-link PF09268.10 KOS19635.1 - 0.096 12.1 0.2 0.28 10.6 0.2 1.9 1 0 0 1 1 1 0 Clathrin, heavy-chain linker TPR_8 PF13181.6 KOS19635.1 - 0.46 10.8 9.4 1.9 8.9 0.0 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOS19635.1 - 1.1 9.3 3.7 14 5.7 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat F-box-like PF12937.7 KOS19637.1 - 3.4e-07 30.0 0.2 7.9e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS19637.1 - 0.00056 19.7 1.0 0.001 18.9 1.0 1.4 1 0 0 1 1 1 1 F-box domain SWIRM PF04433.17 KOS19638.1 - 1.1e-11 44.9 0.0 2e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain GRIP PF01465.20 KOS19640.1 - 1.2e-15 57.1 0.1 2.8e-15 55.9 0.1 1.7 1 0 0 1 1 1 1 GRIP domain DHR10 PF18595.1 KOS19640.1 - 8.4e-05 22.6 17.7 8.4e-05 22.6 17.7 10.3 5 3 4 10 10 10 3 Designed helical repeat protein 10 domain TSC22 PF01166.18 KOS19640.1 - 0.0076 16.5 1.0 0.0076 16.5 1.0 9.7 8 3 4 12 12 11 1 TSC-22/dip/bun family HIP1_clath_bdg PF16515.5 KOS19640.1 - 0.015 15.9 15.1 0.015 15.9 15.1 11.5 2 2 8 10 10 8 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3800 PF12686.7 KOS19640.1 - 0.033 14.8 0.0 11 6.6 0.0 4.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DivIC PF04977.15 KOS19640.1 - 0.06 13.1 0.1 0.06 13.1 0.1 14.4 9 4 5 15 15 14 0 Septum formation initiator APG6_N PF17675.1 KOS19640.1 - 0.17 12.4 171.6 0.044 14.3 18.6 10.3 3 3 7 10 10 9 0 Apg6 coiled-coil region SlyX PF04102.12 KOS19640.1 - 0.66 10.6 0.0 0.66 10.6 0.0 14.4 6 3 5 12 12 10 0 SlyX Cep57_CLD PF14073.6 KOS19640.1 - 0.88 9.6 0.0 0.88 9.6 0.0 8.5 3 2 4 8 8 7 0 Centrosome localisation domain of Cep57 Spc7 PF08317.11 KOS19640.1 - 1.2 7.9 143.9 0.028 13.3 20.5 8.0 2 2 7 10 10 10 0 Spc7 kinetochore protein CALCOCO1 PF07888.11 KOS19640.1 - 6.2 5.6 154.4 0.61 8.9 44.0 4.7 1 1 2 4 4 4 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 KOS19640.1 - 6.5 6.0 141.3 0.26 10.6 20.1 9.8 3 2 7 10 10 10 0 Growth-arrest specific micro-tubule binding Fib_alpha PF08702.10 KOS19640.1 - 9.6 6.4 72.8 0.34 11.1 8.3 8.1 4 3 4 8 8 8 0 Fibrinogen alpha/beta chain family adh_short PF00106.25 KOS19641.1 - 2.7e-37 128.1 0.3 1.5e-36 125.7 0.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS19641.1 - 3.3e-37 128.3 0.4 6.6e-23 81.5 0.2 2.3 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS19641.1 - 5.4e-09 36.2 0.2 5.6e-08 32.9 0.0 2.2 2 1 0 2 2 2 1 KR domain Shikimate_DH PF01488.20 KOS19641.1 - 0.0028 17.7 0.0 0.0058 16.7 0.0 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 KOS19641.1 - 0.033 14.1 0.0 0.075 13.0 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS19641.1 - 0.05 13.1 0.0 0.081 12.4 0.0 1.2 1 0 0 1 1 1 0 Glucose dehydrogenase C-terminus GDP_Man_Dehyd PF16363.5 KOS19641.1 - 0.18 11.2 0.2 0.51 9.7 0.0 1.7 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase zinc_ribbon_10 PF10058.9 KOS19642.1 - 5.2e-19 67.7 0.1 8.6e-19 67.0 0.1 1.4 1 0 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein CCDC-167 PF15188.6 KOS19642.1 - 0.0093 16.3 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 167 NOA36 PF06524.12 KOS19642.1 - 0.016 14.5 5.7 0.028 13.7 5.7 1.4 1 0 0 1 1 1 0 NOA36 protein Menin PF05053.13 KOS19642.1 - 0.2 10.0 7.2 0.27 9.6 7.2 1.1 1 0 0 1 1 1 0 Menin Med8 PF10232.9 KOS19642.1 - 1.7 8.2 5.5 1.3 8.5 3.7 1.7 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 Ribosomal_60s PF00428.19 KOS19642.1 - 2.2 9.0 18.4 0.55 10.8 7.4 2.6 1 1 1 2 2 2 0 60s Acidic ribosomal protein PGA2 PF07543.12 KOS19642.1 - 6.1 6.8 10.6 20 5.2 10.6 1.8 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 KOS19642.1 - 7.9 4.6 13.3 12 4.0 13.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Ank_2 PF12796.7 KOS19643.1 - 3.2e-75 248.8 0.2 6.4e-16 58.7 0.0 6.6 2 1 3 6 6 6 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS19643.1 - 1.3e-62 200.3 3.3 5.2e-05 23.3 0.0 14.2 14 0 0 14 14 14 11 Ankyrin repeat Ank_4 PF13637.6 KOS19643.1 - 3.3e-62 206.1 5.8 8.1e-10 39.0 0.1 11.1 2 1 10 12 12 12 11 Ankyrin repeats (many copies) Ank PF00023.30 KOS19643.1 - 6e-53 175.1 8.4 8.3e-06 26.0 0.0 13.1 13 0 0 13 13 13 11 Ankyrin repeat Ank_5 PF13857.6 KOS19643.1 - 4.4e-52 173.5 9.9 1.1e-07 32.0 0.2 10.0 4 3 6 10 10 10 9 Ankyrin repeats (many copies) F-box-like PF12937.7 KOS19643.1 - 0.0033 17.3 0.1 0.0085 16.0 0.1 1.7 1 0 0 1 1 1 1 F-box-like Arg_repressor PF01316.21 KOS19643.1 - 0.044 13.5 0.1 31 4.4 0.0 3.7 4 0 0 4 4 4 0 Arginine repressor, DNA binding domain Asp_protease_2 PF13650.6 KOS19643.1 - 0.13 12.9 0.3 2.7 8.7 0.2 3.1 3 1 1 4 4 4 0 Aspartyl protease Pkinase PF00069.25 KOS19645.1 - 7.6e-41 140.2 0.0 7.8e-23 81.2 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19645.1 - 5.5e-15 55.4 0.2 3.2e-10 39.7 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Shisa PF13908.6 KOS19645.1 - 0.041 14.1 0.1 0.093 13.0 0.1 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator STAG PF08514.11 KOS19646.1 - 3.5e-34 117.1 0.6 1.4e-33 115.1 0.6 2.1 1 0 0 1 1 1 1 STAG domain HEAT_2 PF13646.6 KOS19646.1 - 1e-05 25.9 0.4 0.00041 20.7 0.0 3.7 3 1 1 4 4 4 2 HEAT repeats DUF3439 PF11921.8 KOS19646.1 - 0.025 14.5 3.9 0.056 13.4 3.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) HEAT PF02985.22 KOS19646.1 - 0.032 14.5 0.1 26 5.4 0.1 4.4 4 0 0 4 4 4 0 HEAT repeat Dicty_REP PF05086.12 KOS19646.1 - 0.067 11.2 5.8 0.18 9.7 5.8 1.7 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 KOS19646.1 - 1.1 9.2 15.0 3.6 7.6 15.0 1.8 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 KOS19646.1 - 4.1 5.5 10.3 6.1 4.9 10.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RNA_pol_Rpc4 PF05132.14 KOS19647.1 - 3.7e-32 111.8 0.0 3.7e-32 111.8 0.0 3.8 3 1 0 3 3 3 1 RNA polymerase III RPC4 Mucin PF01456.17 KOS19647.1 - 0.0053 16.8 14.2 0.0053 16.8 14.2 1.9 2 0 0 2 2 2 1 Mucin-like glycoprotein DUF3439 PF11921.8 KOS19647.1 - 0.36 10.8 9.7 1 9.3 9.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) BSP_II PF05432.11 KOS19647.1 - 0.38 10.4 24.4 11 5.6 21.2 2.5 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) BAF1_ABF1 PF04684.13 KOS19647.1 - 1.6 7.7 10.0 3.2 6.7 10.0 1.5 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor SSP160 PF06933.11 KOS19647.1 - 1.7 6.8 11.8 2.6 6.1 11.8 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 UreD PF01774.17 KOS19648.1 - 3.9e-71 239.3 0.1 4.9e-71 239.0 0.1 1.1 1 0 0 1 1 1 1 UreD urease accessory protein DUF3433 PF11915.8 KOS19649.1 - 1.1e-17 64.3 0.8 1.5e-17 63.8 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3433) DUF3433 PF11915.8 KOS19650.1 - 1e-33 115.6 11.4 2e-20 73.0 1.7 3.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3433) SMI1_KNR4 PF09346.10 KOS19651.1 - 8.7e-32 110.3 0.0 1.9e-31 109.2 0.0 1.6 1 1 0 1 1 1 1 SMI1 / KNR4 family (SUKH-1) PDE8 PF08629.10 KOS19651.1 - 0.044 13.8 0.3 0.044 13.8 0.3 2.4 3 0 0 3 3 3 0 PDE8 phosphodiesterase ArgJ PF01960.18 KOS19652.1 - 4.1e-145 483.2 0.0 4.6e-145 483.1 0.0 1.0 1 0 0 1 1 1 1 ArgJ family IGPD PF00475.18 KOS19653.1 - 9e-58 194.7 0.3 1.4e-57 194.1 0.3 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase RE_XcyI PF09571.10 KOS19653.1 - 0.091 12.0 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 XcyI restriction endonuclease TPR_2 PF07719.17 KOS19654.1 - 1.1e-27 93.9 18.5 0.0012 18.8 0.0 10.4 11 0 0 11 11 11 6 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS19654.1 - 1.8e-26 92.2 13.2 3.2e-24 85.0 0.4 5.1 4 2 2 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 KOS19654.1 - 1.3e-25 88.1 5.7 0.00021 20.9 0.3 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_19 PF14559.6 KOS19654.1 - 2.5e-24 85.5 18.0 0.0015 19.0 0.0 7.6 6 2 1 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 KOS19654.1 - 3e-19 67.5 3.9 0.073 13.3 0.0 9.6 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOS19654.1 - 2.6e-18 66.1 19.7 3.1e-06 27.4 0.0 8.8 7 1 2 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 KOS19654.1 - 1e-15 57.1 22.7 0.01 16.6 0.1 10.0 5 4 4 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 KOS19654.1 - 1.1e-12 48.3 24.2 8.2e-06 26.4 0.0 8.1 5 3 3 8 8 8 3 Tetratricopeptide repeat TPR_10 PF13374.6 KOS19654.1 - 1.9e-10 40.3 13.2 0.022 14.6 0.0 7.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_7 PF13176.6 KOS19654.1 - 4.2e-08 32.7 13.3 0.91 9.7 0.0 8.7 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOS19654.1 - 9.5e-08 31.6 3.0 0.38 10.5 0.0 6.7 7 1 1 8 8 8 2 TPR repeat TPR_6 PF13174.6 KOS19654.1 - 4.3e-06 27.0 9.0 1.8 9.4 0.1 8.0 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS19654.1 - 4.2e-05 23.6 9.3 0.008 16.3 0.1 5.5 6 0 0 6 6 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 KOS19654.1 - 0.00079 18.9 0.4 3.9 6.8 0.0 3.7 3 1 1 4 4 4 2 Coatomer epsilon subunit TPR_4 PF07721.14 KOS19654.1 - 0.0023 18.4 9.3 2 9.3 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 KOS19654.1 - 0.092 12.4 0.1 10 5.8 0.1 3.0 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_21 PF09976.9 KOS19654.1 - 0.13 12.0 9.3 2.7 7.6 0.7 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat-like domain ANAPC5 PF12862.7 KOS19654.1 - 0.19 11.8 2.2 14 5.9 0.0 3.2 2 1 0 3 3 2 0 Anaphase-promoting complex subunit 5 TPR_5 PF12688.7 KOS19654.1 - 0.23 11.7 2.8 1.4 9.1 0.2 3.4 3 1 1 4 4 3 0 Tetratrico peptide repeat FAT PF02259.23 KOS19655.1 - 8.2e-73 245.6 9.1 1.8e-72 244.5 9.1 1.6 1 0 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 KOS19655.1 - 4.8e-32 111.7 0.1 1.9e-31 109.8 0.1 2.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KOS19655.1 - 4.5e-06 26.4 0.2 1e-05 25.2 0.2 1.7 1 0 0 1 1 1 1 FATC domain AAA_32 PF13654.6 KOS19655.1 - 0.024 13.4 0.1 0.058 12.2 0.1 1.6 1 0 0 1 1 1 0 AAA domain Sec7_N PF12783.7 KOS19655.1 - 0.078 12.9 0.6 11 5.9 0.1 3.9 2 0 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_2 PF07719.17 KOS19655.1 - 0.15 12.3 1.7 4 7.8 0.2 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Urb2 PF10441.9 KOS19655.1 - 1.5 8.7 7.4 5.5 6.9 0.2 5.0 4 2 1 5 5 5 0 Urb2/Npa2 family Prefoldin_2 PF01920.20 KOS19656.1 - 8.3e-17 61.1 1.8 9.4e-17 60.9 1.8 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF148 PF02520.17 KOS19656.1 - 0.0019 18.3 0.5 0.0028 17.7 0.5 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF148 CagS PF16707.5 KOS19656.1 - 0.046 13.7 0.1 0.052 13.6 0.1 1.0 1 0 0 1 1 1 0 Cag pathogenicity island protein S of Helicobacter pylori Planc_extracel PF07595.12 KOS19656.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 Planctomycete extracellular Cmc1 PF08583.10 KOS19657.1 - 4.4e-16 58.6 8.3 5.3e-16 58.4 8.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like MerR-DNA-bind PF09278.11 KOS19657.1 - 0.034 14.7 3.3 0.15 12.6 1.0 2.2 2 0 0 2 2 2 0 MerR, DNA binding COX17 PF05051.13 KOS19657.1 - 0.054 13.9 4.9 1.8 8.9 0.9 2.2 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DUF501 PF04417.12 KOS19657.1 - 0.057 13.2 1.7 0.072 12.9 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF501) DUF3128 PF11326.8 KOS19657.1 - 1.4 9.3 5.8 3 8.3 5.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) RRN3 PF05327.11 KOS19658.1 - 1.9e-173 578.0 0.0 1.9e-173 578.0 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 KOS19658.1 - 3.8 7.3 15.0 0.15 11.9 1.5 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region CBFD_NFYB_HMF PF00808.23 KOS19659.1 - 3.4e-30 104.1 0.9 4.4e-30 103.8 0.9 1.1 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOS19659.1 - 3.2e-06 27.5 0.1 4.7e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID-18kDa PF02269.16 KOS19659.1 - 0.00053 19.9 0.0 0.00071 19.5 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Bromo_TP PF07524.13 KOS19659.1 - 0.0011 18.9 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Bromodomain associated CENP-T_C PF15511.6 KOS19659.1 - 0.0018 18.4 0.0 0.0026 17.9 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 KOS19659.1 - 0.012 16.1 0.3 0.073 13.6 0.1 1.9 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A HEAT_EZ PF13513.6 KOS19660.1 - 0.016 15.7 0.1 41 4.8 0.0 3.9 3 0 0 3 3 3 0 HEAT-like repeat DUF3437 PF11919.8 KOS19660.1 - 0.091 12.7 0.2 0.55 10.2 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF3437) DivIC PF04977.15 KOS19661.1 - 0.011 15.5 0.5 0.023 14.5 0.5 1.4 1 0 0 1 1 1 0 Septum formation initiator TetR_C_5 PF08360.11 KOS19662.1 - 0.23 11.6 0.0 0.37 11.0 0.0 1.2 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Mon1 PF03164.14 KOS19663.1 - 4.3e-148 493.7 0.0 5e-148 493.5 0.0 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 EphA2_TM PF14575.6 KOS19664.1 - 0.036 14.9 0.0 0.11 13.4 0.0 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Lustrin_cystein PF14625.6 KOS19664.1 - 0.092 13.1 21.6 1.4 9.3 3.1 3.3 2 1 0 2 2 2 0 Lustrin, cysteine-rich repeated domain Granulin PF00396.18 KOS19664.1 - 0.12 12.7 30.3 0.35 11.3 5.5 3.8 2 1 2 4 4 4 0 Granulin F-box-like PF12937.7 KOS19665.1 - 0.00027 20.8 0.0 0.00053 19.8 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS19665.1 - 0.13 12.2 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 F-box domain Pinin_SDK_N PF04697.13 KOS19665.1 - 0.84 10.3 4.7 0.43 11.2 1.3 2.3 2 1 0 2 2 2 0 pinin/SDK conserved region LSM PF01423.22 KOS19668.1 - 6.3e-18 64.2 0.1 8.7e-18 63.8 0.1 1.2 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 KOS19668.1 - 0.15 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Hfq protein ECH_2 PF16113.5 KOS19669.1 - 2.6e-124 415.1 0.0 3.6e-124 414.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 KOS19669.1 - 2.1e-26 92.8 0.0 4.2e-24 85.2 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase CDPS PF16715.5 KOS19669.1 - 0.12 12.0 1.5 1.9 8.1 0.0 2.3 2 0 0 2 2 2 0 Cyclodipeptide synthase HTH_32 PF13565.6 KOS19669.1 - 1.7 9.3 4.5 1e+02 3.6 0.0 3.8 3 1 0 3 3 3 0 Homeodomain-like domain Glyco_hydro_76 PF03663.14 KOS19670.1 - 1.8e-125 419.3 14.2 2.3e-125 418.9 14.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOS19670.1 - 0.051 12.7 6.1 1.5 7.8 0.2 3.1 2 1 0 3 3 3 0 Glycosyl Hydrolase Family 88 DNA_ligase_A_M PF01068.21 KOS19671.1 - 8.3e-20 71.3 0.0 1.2e-19 70.7 0.0 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain PNKP_ligase PF16542.5 KOS19671.1 - 0.13 11.8 0.0 0.39 10.2 0.0 1.7 2 0 0 2 2 2 0 PNKP adenylyltransferase domain, ligase domain mRNA_cap_enzyme PF01331.19 KOS19671.1 - 0.2 11.4 0.0 0.45 10.3 0.0 1.5 2 0 0 2 2 2 0 mRNA capping enzyme, catalytic domain DUF4048 PF13257.6 KOS19672.1 - 2.4e-10 40.7 6.0 2.8e-09 37.2 2.4 2.9 2 1 0 2 2 2 1 Domain of unknown function (DUF4048) Serglycin PF04360.12 KOS19672.1 - 0.054 13.4 0.2 0.12 12.3 0.2 1.7 1 0 0 1 1 1 0 Serglycin MKT1_C PF12246.8 KOS19673.1 - 3.2e-67 226.3 0.0 4.5e-67 225.8 0.0 1.2 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 KOS19673.1 - 9.5e-29 99.6 0.0 2.4e-28 98.3 0.0 1.7 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication DIOX_N PF14226.6 KOS19674.1 - 2.5e-22 79.8 0.0 4.9e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOS19674.1 - 2.2e-14 53.8 0.0 5.2e-14 52.6 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily G-alpha PF00503.20 KOS19675.1 - 2e-124 415.4 3.7 2.3e-124 415.2 3.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOS19675.1 - 2.6e-15 56.3 1.5 2.8e-10 39.9 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family zf-CHC2 PF01807.20 KOS19675.1 - 8.3e-05 22.3 0.0 0.00036 20.3 0.0 2.0 2 0 0 2 2 2 1 CHC2 zinc finger Gtr1_RagA PF04670.12 KOS19675.1 - 0.0022 17.4 2.6 0.11 11.8 0.0 2.5 2 1 0 2 2 2 2 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 KOS19675.1 - 0.013 15.2 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 KOS19675.1 - 0.02 15.1 0.2 2.5 8.4 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MCM PF00493.23 KOS19675.1 - 0.057 12.5 0.1 0.11 11.6 0.1 1.5 1 1 0 1 1 1 0 MCM P-loop domain GTP_EFTU PF00009.27 KOS19675.1 - 0.13 11.8 0.0 1.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS19675.1 - 0.13 12.3 0.0 8.7 6.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.18 KOS19675.1 - 0.13 11.5 0.0 0.28 10.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family D123 PF07065.14 KOS19676.1 - 1.6e-112 375.7 0.0 1.8e-112 375.4 0.0 1.0 1 0 0 1 1 1 1 D123 NOA36 PF06524.12 KOS19676.1 - 6.4 6.0 28.1 4.3 6.6 20.2 2.1 2 0 0 2 2 2 0 NOA36 protein Nup188_C PF18378.1 KOS19677.1 - 1.6e-156 520.8 1.3 2.5e-156 520.2 1.3 1.3 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain Nup188 PF10487.9 KOS19677.1 - 3.8e-46 157.5 4.2 3.6e-34 117.9 3.5 2.6 2 1 0 2 2 2 2 Nucleoporin subcomplex protein binding to Pom34 zf-Tim10_DDP PF02953.15 KOS19678.1 - 3e-19 68.4 1.8 3e-19 68.4 1.8 1.6 2 0 0 2 2 2 1 Tim10/DDP family zinc finger Hormone_recep PF00104.30 KOS19678.1 - 0.0093 15.6 0.2 0.01 15.5 0.2 1.0 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor RhoGAP PF00620.27 KOS19679.1 - 3e-37 127.8 0.0 4.8e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DUF4718 PF15842.5 KOS19679.1 - 2.7 7.8 7.2 13 5.5 7.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4718) Plasmodium_Vir PF05795.11 KOS19679.1 - 8.4 5.7 5.3 23 4.3 5.3 1.7 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Glyco_transf_22 PF03901.17 KOS19680.1 - 2.8e-75 254.1 2.5 4.1e-75 253.6 2.5 1.2 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family cwf21 PF08312.12 KOS19681.1 - 1.1e-17 63.9 14.9 2.5e-17 62.7 14.9 1.6 1 0 0 1 1 1 1 cwf21 domain Filament PF00038.21 KOS19681.1 - 0.0042 16.7 9.4 0.0049 16.5 9.4 1.0 1 0 0 1 1 1 1 Intermediate filament protein GvpG PF05120.12 KOS19681.1 - 0.07 13.1 6.0 0.19 11.7 1.9 2.3 2 0 0 2 2 2 0 Gas vesicle protein G Use1 PF09753.9 KOS19682.1 - 4.7e-07 29.8 0.0 9.3e-07 28.8 0.0 1.6 1 1 0 1 1 1 1 Membrane fusion protein Use1 IGPS PF00218.21 KOS19684.1 - 3.4e-95 318.0 0.1 5.6e-95 317.3 0.0 1.4 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 KOS19684.1 - 4e-46 157.2 0.0 9.5e-46 156.0 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase class-I PRAI PF00697.22 KOS19684.1 - 4.7e-46 157.0 0.1 1.7e-41 142.2 0.0 2.4 1 1 1 2 2 2 2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase QRPTase_C PF01729.19 KOS19684.1 - 2.4e-06 27.4 0.4 0.00015 21.6 0.1 2.7 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, C-terminal domain Peptidase_C26 PF07722.13 KOS19684.1 - 7e-05 22.7 0.0 0.00022 21.1 0.0 1.8 1 1 0 1 1 1 1 Peptidase C26 FMN_dh PF01070.18 KOS19684.1 - 0.017 14.2 0.2 0.039 13.0 0.2 1.5 1 0 0 1 1 1 0 FMN-dependent dehydrogenase YjeF_N PF03853.15 KOS19684.1 - 0.024 14.5 1.6 6.8 6.6 0.0 3.3 3 0 0 3 3 3 0 YjeF-related protein N-terminus Abhydrolase_1 PF00561.20 KOS19685.1 - 1.3e-14 54.5 0.0 8e-14 51.9 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS19685.1 - 1.3e-08 34.5 0.0 5e-08 32.5 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Pkinase PF00069.25 KOS19686.1 - 5.2e-70 235.8 0.0 7.5e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19686.1 - 8.3e-36 123.6 0.0 1.5e-35 122.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19686.1 - 0.00035 20.0 0.0 0.00056 19.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 KOS19686.1 - 0.0027 17.1 0.0 0.0071 15.7 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CAF1C_H4-bd PF12265.8 KOS19687.1 - 9.1e-27 93.1 0.3 3.5e-26 91.3 0.2 2.1 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 KOS19687.1 - 3.4e-24 84.6 5.9 1.8e-06 28.5 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19687.1 - 0.00014 22.0 0.6 0.045 14.1 0.1 3.7 2 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain XRN_N PF03159.18 KOS19688.1 - 5.4e-97 324.0 0.0 1.1e-96 323.0 0.0 1.5 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 KOS19688.1 - 1.4e-95 320.9 3.0 2.9e-95 319.8 3.0 1.5 1 0 0 1 1 1 1 Xrn1 helical domain XRN1_D1 PF18332.1 KOS19688.1 - 1.9e-71 239.8 0.0 4.8e-71 238.5 0.0 1.7 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 KOS19688.1 - 1.1e-33 115.3 0.0 3.9e-33 113.5 0.0 2.1 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 KOS19688.1 - 5.2e-21 74.5 0.1 1.1e-20 73.5 0.1 1.6 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 KOS19688.1 - 9.2e-06 25.7 0.2 2.2e-05 24.5 0.2 1.7 1 0 0 1 1 1 1 Exoribonuclease 1 Domain-3 Sterile PF03015.19 KOS19688.1 - 0.12 12.6 0.0 0.52 10.6 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein R3H PF01424.22 KOS19688.1 - 0.14 12.2 0.0 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 R3H domain SPC22 PF04573.12 KOS19689.1 - 1.1e-38 132.4 0.1 2e-37 128.3 0.1 2.0 1 1 0 1 1 1 1 Signal peptidase subunit WASH-7_C PF14746.6 KOS19690.1 - 0.063 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Pmp3 PF01679.17 KOS19692.1 - 9.6e-10 38.5 6.2 1.6e-09 37.8 6.2 1.4 1 1 0 1 1 1 1 Proteolipid membrane potential modulator zf-RanBP PF00641.18 KOS19693.1 - 2.2e-18 65.3 13.3 8e-11 41.1 1.6 2.3 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RNase_T PF00929.24 KOS19693.1 - 3.6e-06 27.6 0.0 5.1e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Exonuclease RRM_1 PF00076.22 KOS19693.1 - 5.1e-05 23.0 0.0 9.9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transket_pyr PF02779.24 KOS19695.1 - 4.1e-63 212.3 0.0 6.7e-63 211.6 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 KOS19695.1 - 1.2e-56 191.9 0.0 2e-56 191.2 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 KOS19695.1 - 2e-54 183.4 0.1 3.5e-54 182.6 0.1 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 KOS19695.1 - 7.3e-20 70.3 1.3 1.5e-19 69.3 1.3 1.6 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase N-terminus Glyco_hydro_17 PF00332.18 KOS19695.1 - 0.037 13.6 0.7 1.7 8.1 0.4 2.3 2 0 0 2 2 2 0 Glycosyl hydrolases family 17 baeRF_family12 PF18856.1 KOS19695.1 - 0.15 12.6 0.7 0.92 10.1 0.0 2.4 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 12 BioY PF02632.14 KOS19695.1 - 0.2 11.7 0.2 0.35 10.9 0.2 1.3 1 0 0 1 1 1 0 BioY family MIF4G PF02854.19 KOS19696.1 - 1.9e-52 178.0 0.0 3.9e-52 177.0 0.0 1.5 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 KOS19696.1 - 3e-22 78.6 0.2 1.6e-21 76.3 0.2 2.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 DUF4148 PF13663.6 KOS19696.1 - 0.0086 16.2 2.3 1 9.6 0.1 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4148) Eno-Rase_FAD_bd PF07055.12 KOS19696.1 - 0.21 12.0 0.9 0.52 10.8 0.0 2.1 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Mito_carr PF00153.27 KOS19697.1 - 3.2e-21 75.0 1.9 2.6e-09 36.9 0.1 2.7 2 1 0 2 2 2 2 Mitochondrial carrier protein SPT2 PF08243.11 KOS19698.1 - 2.4e-11 44.1 27.1 2.5e-10 40.9 13.0 2.3 1 1 1 2 2 2 2 SPT2 chromatin protein PBP1_TM PF14812.6 KOS19698.1 - 0.012 15.9 5.0 0.012 15.9 5.0 2.9 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3419 PF11899.8 KOS19699.1 - 1.2e-158 528.4 0.0 1.5e-158 528.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3419) CybS PF05328.12 KOS19700.1 - 6.1e-52 174.8 0.0 7.5e-52 174.5 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit tRNA-synt_1b PF00579.25 KOS19701.1 - 2.3e-73 247.1 0.0 3e-73 246.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) TyrRSs_C PF16714.5 KOS19701.1 - 6.5e-46 155.0 0.0 2.5e-45 153.1 0.0 1.9 2 0 0 2 2 2 1 Tyrosyl-tRNA synthetase C-terminal domain NPR2 PF06218.11 KOS19702.1 - 1.7e-116 389.6 0.0 1.2e-95 320.9 0.0 2.1 1 1 1 2 2 2 2 Nitrogen permease regulator 2 DUF572 PF04502.13 KOS19703.1 - 7.7e-64 216.4 6.8 9.3e-64 216.1 6.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) Dynamitin PF04912.14 KOS19703.1 - 0.0083 15.5 1.9 0.01 15.2 1.9 1.1 1 0 0 1 1 1 1 Dynamitin DUF951 PF06107.11 KOS19703.1 - 0.17 11.8 0.4 20 5.2 0.1 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF951) zf-ACC PF17848.1 KOS19703.1 - 0.35 11.0 4.1 6.9 6.9 0.7 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Kin17_mid PF10357.9 KOS19704.1 - 2.7e-52 175.9 1.6 2.7e-52 175.9 1.6 1.9 3 0 0 3 3 3 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 KOS19704.1 - 0.00022 21.4 0.8 0.00048 20.3 0.8 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS19704.1 - 0.0021 18.4 2.1 0.0041 17.5 2.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 KOS19704.1 - 0.047 14.0 0.2 0.047 14.0 0.2 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Spt4 PF06093.13 KOS19705.1 - 9.9e-33 112.1 0.0 1.2e-32 111.8 0.0 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger Coronavirus_5 PF05528.11 KOS19705.1 - 0.15 12.1 0.3 0.38 10.8 0.3 1.8 1 1 0 1 1 1 0 Coronavirus gene 5 protein PPP5 PF08321.12 KOS19707.1 - 1.4e-31 108.6 1.5 3.6e-31 107.3 0.2 2.1 2 0 0 2 2 2 1 PPP5 TPR repeat region Metallophos PF00149.28 KOS19707.1 - 1.5e-30 107.2 0.0 2.4e-30 106.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase TPR_1 PF00515.28 KOS19707.1 - 2.5e-16 58.7 0.4 0.00078 19.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS19707.1 - 7.6e-13 47.5 0.8 0.0083 16.2 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS19707.1 - 3.2e-09 36.3 0.7 0.016 14.9 0.0 3.4 3 0 0 3 3 3 3 TPR repeat TPR_9 PF13371.6 KOS19707.1 - 0.00011 22.3 0.1 0.00042 20.4 0.1 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOS19707.1 - 0.00024 21.1 0.6 1.5 9.2 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS19707.1 - 0.0011 19.5 0.1 0.47 11.0 0.0 2.7 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS19707.1 - 0.0023 18.2 1.8 1.2 9.6 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS19707.1 - 0.017 15.4 0.2 0.92 9.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat PIN_5 PF08745.11 KOS19707.1 - 0.028 13.9 0.1 0.044 13.2 0.1 1.2 1 0 0 1 1 1 0 PINc domain ribonuclease TPR_16 PF13432.6 KOS19707.1 - 0.032 14.9 2.2 2.3 8.9 0.2 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 KOS19707.1 - 0.056 13.5 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 KOS19707.1 - 0.087 13.7 1.8 29 5.8 0.1 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOS19707.1 - 0.12 13.1 1.5 4.1 8.3 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat Es2 PF09751.9 KOS19708.1 - 1.3e-114 384.3 0.7 2.1e-114 383.6 0.7 1.3 1 0 0 1 1 1 1 Nuclear protein Es2 CTD PF12815.7 KOS19708.1 - 0.13 12.8 3.1 0.53 10.9 0.1 2.7 3 0 0 3 3 3 0 Spt5 C-terminal nonapeptide repeat binding Spt4 p450 PF00067.22 KOS19709.1 - 2.9e-45 154.9 0.0 3.8e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KOS19711.1 - 3.5e-29 101.9 0.0 4.6e-29 101.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Sugar_tr PF00083.24 KOS19712.1 - 1.3e-15 57.2 0.6 1.5e-15 57.0 0.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter DUF998 PF06197.13 KOS19712.1 - 0.89 9.1 15.6 3.9 7.0 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF998) Bot1p PF12298.8 KOS19713.1 - 6.1e-49 166.5 0.5 1e-48 165.8 0.1 1.6 2 0 0 2 2 2 1 Eukaryotic mitochondrial regulator protein LysM PF01476.20 KOS19713.1 - 0.022 14.8 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 LysM domain HATPase_c PF02518.26 KOS19714.1 - 4.3e-21 75.5 0.1 1.1e-20 74.2 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS19714.1 - 3.2e-16 59.5 0.0 2e-15 56.9 0.0 2.2 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 KOS19714.1 - 2.7e-08 33.7 0.0 8.8e-08 32.1 0.0 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF PF01590.26 KOS19714.1 - 3e-07 31.1 0.0 7e-06 26.7 0.0 2.9 3 0 0 3 3 3 1 GAF domain Mucin PF01456.17 KOS19714.1 - 0.013 15.5 19.6 0.031 14.3 19.6 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein Rota_NS6 PF04866.12 KOS19714.1 - 0.13 12.5 0.0 0.31 11.3 0.0 1.6 1 0 0 1 1 1 0 Rotavirus non-structural protein 6 PEX11 PF05648.14 KOS19715.1 - 2e-05 24.2 0.7 0.00055 19.5 0.1 3.9 3 1 0 3 3 2 2 Peroxisomal biogenesis factor 11 (PEX11) DUF4834 PF16118.5 KOS19715.1 - 8.9e-05 23.4 5.6 0.00014 22.8 5.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) MAP17 PF15807.5 KOS19715.1 - 0.00012 22.3 3.6 0.00015 22.0 1.4 1.9 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 AIF_C PF14721.6 KOS19715.1 - 0.0027 18.1 2.9 0.004 17.5 2.9 1.2 1 0 0 1 1 1 1 Apoptosis-inducing factor, mitochondrion-associated, C-term G0-G1_switch_2 PF15103.6 KOS19715.1 - 0.0037 17.7 3.3 0.0059 17.0 3.3 1.3 1 0 0 1 1 1 1 G0/G1 switch protein 2 FAM176 PF14851.6 KOS19715.1 - 0.0059 16.3 1.8 0.0096 15.6 1.8 1.3 1 0 0 1 1 1 1 FAM176 family DDHD PF02862.17 KOS19715.1 - 0.0064 16.7 0.2 0.0075 16.5 0.2 1.2 1 0 0 1 1 1 1 DDHD domain CPSF100_C PF13299.6 KOS19715.1 - 0.01 16.0 4.0 0.015 15.5 4.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIIBC-GUT_N PF03612.14 KOS19715.1 - 0.012 15.4 2.4 0.016 15.0 2.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TMEM51 PF15345.6 KOS19715.1 - 0.013 15.3 2.9 0.022 14.6 2.9 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 SID-1_RNA_chan PF13965.6 KOS19715.1 - 0.015 13.7 0.2 0.02 13.3 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 OATP PF03137.20 KOS19715.1 - 0.016 13.6 0.9 0.02 13.2 0.9 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CobT PF06213.12 KOS19715.1 - 0.027 13.9 14.9 0.04 13.3 14.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CBP_BcsG PF11658.8 KOS19715.1 - 0.03 12.8 2.3 0.043 12.2 0.4 1.8 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Presenilin PF01080.17 KOS19715.1 - 0.032 13.0 5.2 0.049 12.4 5.2 1.2 1 0 0 1 1 1 0 Presenilin Serinc PF03348.15 KOS19715.1 - 0.045 12.7 0.2 0.056 12.4 0.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) EphA2_TM PF14575.6 KOS19715.1 - 0.061 14.2 6.0 0.24 12.3 6.0 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Connexin PF00029.19 KOS19715.1 - 0.069 12.9 7.1 0.097 12.4 7.1 1.1 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 KOS19715.1 - 0.088 12.9 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region R3H-assoc PF13902.6 KOS19715.1 - 0.091 13.1 10.9 0.15 12.4 10.9 1.3 1 0 0 1 1 1 0 R3H-associated N-terminal domain DUF5362 PF17319.2 KOS19715.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5362) EOS1 PF12326.8 KOS19715.1 - 0.13 12.2 0.2 0.19 11.6 0.2 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.12 KOS19715.1 - 0.13 11.2 2.0 0.19 10.6 2.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ctr PF04145.15 KOS19715.1 - 0.13 12.9 0.3 0.25 12.0 0.3 1.5 1 0 0 1 1 1 0 Ctr copper transporter family FHIPEP PF00771.20 KOS19715.1 - 0.15 10.5 0.7 0.19 10.1 0.7 1.1 1 0 0 1 1 1 0 FHIPEP family RbsD_FucU PF05025.13 KOS19715.1 - 0.17 12.3 1.2 0.32 11.4 1.2 1.3 1 0 0 1 1 1 0 RbsD / FucU transport protein family Ureide_permease PF07168.11 KOS19715.1 - 0.17 10.6 0.5 0.25 10.1 0.5 1.2 1 0 0 1 1 1 0 Ureide permease CCDC53 PF10152.9 KOS19715.1 - 0.22 11.9 8.2 0.43 11.0 8.2 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex TRM13 PF05206.14 KOS19715.1 - 0.23 10.9 6.1 0.34 10.4 6.1 1.1 1 0 0 1 1 1 0 Methyltransferase TRM13 HA2 PF04408.23 KOS19715.1 - 0.26 11.6 2.2 0.52 10.6 2.2 1.4 1 0 0 1 1 1 0 Helicase associated domain (HA2) K_trans PF02705.16 KOS19715.1 - 0.28 9.7 0.2 0.37 9.3 0.2 1.1 1 0 0 1 1 1 0 K+ potassium transporter V_ATPase_I PF01496.19 KOS19715.1 - 0.32 8.9 6.6 0.4 8.5 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family O-antigen_lig PF13425.6 KOS19715.1 - 0.36 9.6 0.9 0.49 9.1 0.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Spt20 PF12090.8 KOS19715.1 - 0.37 10.4 22.8 0.52 9.9 22.8 1.1 1 0 0 1 1 1 0 Spt20 family Rxt3 PF08642.10 KOS19715.1 - 0.44 11.3 3.9 0.63 10.8 3.9 1.2 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 Peptidase_S49_N PF08496.10 KOS19715.1 - 0.49 10.4 10.3 0.76 9.8 10.3 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PcfK PF14058.6 KOS19715.1 - 0.65 10.3 17.2 0.93 9.8 17.2 1.2 1 0 0 1 1 1 0 PcfK-like protein CLN3 PF02487.17 KOS19715.1 - 0.8 8.7 3.4 1.1 8.2 3.4 1.1 1 0 0 1 1 1 0 CLN3 protein SpoIIP PF07454.11 KOS19715.1 - 0.86 9.0 12.0 1.2 8.6 12.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Coilin_N PF15862.5 KOS19715.1 - 0.93 9.3 17.3 1.3 8.8 17.3 1.2 1 0 0 1 1 1 0 Coilin N-terminus MscS_TM PF12794.7 KOS19715.1 - 0.96 8.2 4.2 1.8 7.4 4.2 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF4770 PF15994.5 KOS19715.1 - 1 9.6 11.0 1.5 9.0 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) EMC3_TMCO1 PF01956.16 KOS19715.1 - 1.7 8.3 9.3 2.9 7.6 9.3 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Paf1 PF03985.13 KOS19715.1 - 2.2 7.2 18.9 2.7 6.9 18.9 1.1 1 0 0 1 1 1 0 Paf1 Peroxin-13_N PF04088.13 KOS19715.1 - 2.8 8.2 6.2 1.8 8.9 4.0 1.7 2 0 0 2 2 1 0 Peroxin 13, N-terminal region PTPRCAP PF15713.5 KOS19715.1 - 3.5 7.9 14.4 5.3 7.3 14.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated eIF3_subunit PF08597.10 KOS19715.1 - 3.8 7.3 22.6 5.6 6.8 22.6 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF3767 PF12597.8 KOS19715.1 - 3.9 7.4 6.1 6.9 6.6 6.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3767) Eapp_C PF10238.9 KOS19715.1 - 4 7.5 12.3 5.8 7.0 12.3 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein GTA_holin_3TM PF11351.8 KOS19715.1 - 4.7 7.8 6.4 1.3e+02 3.1 7.6 2.1 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release TMEM214 PF10151.9 KOS19715.1 - 6.9 5.0 11.4 9.1 4.6 11.4 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator MFS_1 PF07690.16 KOS19716.1 - 3.3e-18 65.7 60.4 1.3e-15 57.3 47.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS19717.1 - 2.2e-17 63.1 0.0 5.6e-11 42.0 0.0 2.7 1 1 1 2 2 2 2 Sugar (and other) transporter Bd3614-deam PF14439.6 KOS19717.1 - 0.07 13.2 0.9 0.13 12.4 0.9 1.4 1 0 0 1 1 1 0 Bd3614-like deaminase FAD_binding_4 PF01565.23 KOS19718.1 - 1.8e-19 69.9 0.1 3.3e-19 69.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS19718.1 - 3.8e-13 49.3 0.3 2.3e-12 46.8 0.2 2.2 2 0 0 2 2 2 1 Berberine and berberine like Cytokin-bind PF09265.10 KOS19718.1 - 0.16 11.3 0.1 0.24 10.8 0.1 1.2 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF4735 PF15882.5 KOS19719.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4735) LysM PF01476.20 KOS19721.1 - 6.4e-11 42.1 0.2 0.00019 21.4 0.0 2.2 2 0 0 2 2 2 2 LysM domain Mucin PF01456.17 KOS19721.1 - 0.012 15.6 23.3 0.018 15.1 23.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Alpha_GJ PF03229.13 KOS19721.1 - 0.1 13.1 13.3 0.17 12.5 13.3 1.3 1 0 0 1 1 1 0 Alphavirus glycoprotein J Dicty_REP PF05086.12 KOS19721.1 - 0.13 10.2 3.4 0.14 10.1 3.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SprA-related PF12118.8 KOS19721.1 - 0.14 11.3 8.1 0.15 11.1 8.1 1.1 1 0 0 1 1 1 0 SprA-related family Sporozoite_P67 PF05642.11 KOS19721.1 - 0.16 10.0 11.4 0.18 9.9 11.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 KOS19721.1 - 0.2 12.1 11.6 0.3 11.6 11.6 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Herpes_capsid PF06112.11 KOS19721.1 - 0.23 11.5 12.7 0.31 11.1 12.7 1.1 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SWI-SNF_Ssr4 PF08549.10 KOS19721.1 - 0.8 8.3 3.4 0.89 8.1 3.4 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SRI PF08236.11 KOS19725.1 - 4.3e-21 74.9 2.9 1.3e-20 73.3 2.9 1.9 1 0 0 1 1 1 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 KOS19725.1 - 1.9e-17 64.2 0.3 1.9e-17 64.2 0.3 3.7 3 3 0 3 3 3 1 SET domain AWS PF17907.1 KOS19725.1 - 1.2e-11 44.4 7.0 1.2e-11 44.4 7.0 2.2 2 0 0 2 2 2 1 AWS domain Med26 PF08711.11 KOS19725.1 - 3e-07 30.4 0.1 7.7e-07 29.0 0.1 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain WW PF00397.26 KOS19725.1 - 4.3e-05 23.5 0.2 9.3e-05 22.4 0.2 1.6 1 0 0 1 1 1 1 WW domain DUF2431 PF10354.9 KOS19726.1 - 2e-53 181.1 0.0 2.8e-52 177.4 0.0 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) SDA1 PF05285.12 KOS19726.1 - 0.0012 18.3 29.6 0.0012 18.3 29.6 2.4 3 0 0 3 3 3 1 SDA1 Presenilin PF01080.17 KOS19726.1 - 0.97 8.1 35.3 0.32 9.7 15.9 2.1 2 0 0 2 2 2 0 Presenilin Ndc1_Nup PF09531.10 KOS19726.1 - 0.98 8.0 12.0 1.3 7.7 12.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peptidase_U57 PF05582.12 KOS19726.1 - 1.1 8.4 12.1 1.7 7.8 12.1 1.3 1 0 0 1 1 1 0 YabG peptidase U57 Glyco_hydro_18 PF00704.28 KOS19727.1 - 8e-44 150.6 0.5 1.3e-43 149.9 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Hce2 PF14856.6 KOS19727.1 - 5e-16 58.8 3.4 7.6e-16 58.3 0.1 3.0 3 0 0 3 3 3 1 Pathogen effector; putative necrosis-inducing factor LysM PF01476.20 KOS19727.1 - 4.9e-08 32.9 0.0 0.015 15.4 0.0 2.8 2 0 0 2 2 2 2 LysM domain Chitin_bind_1 PF00187.19 KOS19727.1 - 0.00012 22.5 9.3 0.00012 22.5 9.3 3.8 4 0 0 4 4 4 1 Chitin recognition protein MHC_I PF00129.18 KOS19727.1 - 0.14 11.7 0.4 19 4.7 0.0 2.5 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Aminotran_3 PF00202.21 KOS19728.1 - 7.5e-111 370.6 0.0 8.6e-111 370.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Mur_ligase_M PF08245.12 KOS19729.1 - 9.9e-05 22.4 0.0 0.00042 20.4 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 KOS19729.1 - 0.063 13.5 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain GFA PF04828.14 KOS19730.1 - 1.6e-09 38.0 3.2 7.6e-06 26.2 0.0 2.7 3 0 0 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme Ribosomal_S17_N PF16205.5 KOS19731.1 - 3e-31 107.6 0.1 4.9e-31 106.9 0.1 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 KOS19731.1 - 7.6e-27 93.2 0.5 1.3e-26 92.4 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 Spc7_N PF15402.6 KOS19732.1 - 5.9e-43 147.3 52.7 1.8e-19 69.6 3.4 3.1 1 1 2 3 3 3 3 N-terminus of kinetochore NMS complex subunit Spc7 DUF2167 PF09935.9 KOS19732.1 - 0.077 12.1 0.5 0.13 11.4 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) DUF3835 PF12927.7 KOS19733.1 - 1.1e-22 80.7 0.5 1.1e-22 80.7 0.5 4.5 4 1 0 4 4 4 1 Domain of unknown function (DUF3835) CBFD_NFYB_HMF PF00808.23 KOS19733.1 - 0.063 13.6 0.3 0.17 12.2 0.3 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone RNA_pol_3_Rpc31 PF11705.8 KOS19733.1 - 3.4 7.8 24.5 1.9 8.7 2.2 2.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PBP1_TM PF14812.6 KOS19733.1 - 5.3 7.5 15.4 1.7 9.0 10.3 3.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 KOS19733.1 - 9.9 5.4 11.1 19 4.4 11.1 1.5 1 0 0 1 1 1 0 NOA36 protein 17kDa_Anti_2 PF16998.5 KOS19734.1 - 0.072 13.0 0.1 0.51 10.3 0.1 2.2 2 0 0 2 2 2 0 17 kDa outer membrane surface antigen MIase PF02426.16 KOS19734.1 - 0.32 11.2 4.0 0.72 10.0 0.0 2.9 3 1 1 4 4 4 0 Muconolactone delta-isomerase DUF1713 PF08213.11 KOS19735.1 - 4.6e-10 39.2 21.3 7.7e-10 38.5 21.3 1.4 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) Pet20 PF08692.10 KOS19735.1 - 0.006 17.3 0.0 0.011 16.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial protein Pet20 GNAT_acetyltr_2 PF13718.6 KOS19736.1 - 1.9e-98 328.4 0.0 3.6e-98 327.5 0.0 1.5 1 0 0 1 1 1 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 KOS19736.1 - 2e-86 289.5 0.8 3.3e-86 288.8 0.0 1.8 2 0 0 2 2 2 1 Possible tRNA binding domain Helicase_RecD PF05127.14 KOS19736.1 - 1.5e-64 217.1 0.0 6.5e-64 215.0 0.0 2.1 2 0 0 2 2 2 1 Helicase DUF1726 PF08351.11 KOS19736.1 - 1.9e-31 107.8 0.0 4.9e-31 106.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 KOS19736.1 - 0.00016 21.4 0.1 0.015 15.1 0.1 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS19736.1 - 0.0015 18.8 0.0 0.11 12.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain DprA_WH PF17782.1 KOS19736.1 - 0.032 14.4 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 DprA winged helix domain Acetyltransf_1 PF00583.25 KOS19736.1 - 0.058 13.6 0.0 0.57 10.4 0.0 2.4 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family Spc7 PF08317.11 KOS19737.1 - 1.2e-117 392.3 5.5 1.5e-117 392.0 5.5 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Spc7_C2 PF15577.6 KOS19737.1 - 1.5e-22 79.4 0.4 3e-22 78.5 0.4 1.5 1 0 0 1 1 1 1 Spc7_C2 DUF615 PF04751.14 KOS19737.1 - 0.0012 18.8 2.7 0.0027 17.7 2.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF615) Exonuc_VII_L PF02601.15 KOS19737.1 - 0.026 14.1 3.2 0.039 13.5 3.2 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit THOC7 PF05615.13 KOS19737.1 - 0.1 12.8 4.7 0.31 11.3 4.7 1.8 1 0 0 1 1 1 0 Tho complex subunit 7 Peptidase_C50 PF03568.17 KOS19737.1 - 0.14 11.3 2.7 0.19 10.8 2.7 1.2 1 0 0 1 1 1 0 Peptidase family C50 VPS38 PF17649.1 KOS19737.1 - 0.17 10.7 0.6 0.31 9.9 0.6 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting 38 ADIP PF11559.8 KOS19737.1 - 1.4 9.0 8.6 0.53 10.4 2.0 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding UPF0242 PF06785.11 KOS19737.1 - 6.2 6.9 10.9 12 5.9 8.9 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Mpv17_PMP22 PF04117.12 KOS19738.1 - 1.7e-25 89.0 4.2 2.9e-25 88.3 4.2 1.3 1 0 0 1 1 1 1 Mpv17 / PMP22 family Cys_Met_Meta_PP PF01053.20 KOS19739.1 - 8.4e-57 192.4 0.0 1.7e-43 148.7 0.0 2.6 2 1 0 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOS19739.1 - 0.12 11.4 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V Polysacc_deac_1 PF01522.21 KOS19740.1 - 2.6e-17 62.9 0.0 3.8e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_deac_2 PF04748.13 KOS19740.1 - 0.017 14.3 0.0 0.043 13.0 0.0 1.7 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase GFRP PF06399.13 KOS19740.1 - 0.066 13.1 0.0 2.4 8.1 0.0 3.0 3 1 0 3 3 3 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) OppC_N PF12911.7 KOS19740.1 - 0.1 12.6 0.7 0.24 11.4 0.7 1.6 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C zf-C3HC4_2 PF13923.6 KOS19742.1 - 3.3 7.6 12.0 4.9 7.1 12.0 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EF-hand_1 PF00036.32 KOS19743.1 - 1.3e-25 87.0 6.1 3.7e-06 26.1 0.1 5.3 5 0 0 5 5 5 5 EF hand EF-hand_7 PF13499.6 KOS19743.1 - 5.5e-24 84.4 1.6 1.5e-10 41.4 0.0 3.4 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 KOS19743.1 - 9e-21 72.0 4.5 0.00061 19.5 0.1 5.4 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 KOS19743.1 - 2.5e-16 59.2 6.7 1e-05 25.3 0.1 5.1 4 1 1 5 5 5 5 EF-hand domain pair EF-hand_5 PF13202.6 KOS19743.1 - 6.2e-16 57.1 1.8 0.0015 17.9 0.1 4.4 4 0 0 4 4 4 4 EF hand Presenilin PF01080.17 KOS19743.1 - 0.041 12.7 7.9 0.047 12.5 7.9 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 KOS19743.1 - 0.053 12.2 1.5 0.062 12.0 1.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 KOS19743.1 - 0.74 9.7 32.6 1.1 9.1 32.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 KOS19743.1 - 1.8 7.7 17.8 2.4 7.3 17.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Hydin_ADK PF17213.3 KOS19743.1 - 2.1 8.6 11.2 3.1 8.0 11.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Zip PF02535.22 KOS19743.1 - 3.8 6.7 11.5 4.7 6.3 11.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Lin-8 PF03353.15 KOS19743.1 - 5.1 6.6 22.1 6.9 6.1 22.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist ChaC PF04752.12 KOS19744.1 - 4.9e-38 131.0 0.0 6.8e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 ChaC-like protein WD40 PF00400.32 KOS19746.1 - 3.8e-16 59.2 8.3 0.007 17.2 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 KOS19746.1 - 4.7e-05 22.2 2.3 8.4e-05 21.4 0.8 2.2 1 1 1 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOS19746.1 - 8.2e-05 22.8 0.3 0.0085 16.4 0.1 3.7 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KOS19746.1 - 0.0081 15.1 0.8 0.98 8.3 0.4 2.5 2 0 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain HA2 PF04408.23 KOS19747.1 - 1.7e-22 79.8 0.0 1.7e-22 79.8 0.0 3.7 4 1 0 4 4 3 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOS19747.1 - 7.1e-20 71.2 0.0 2.8e-19 69.3 0.0 2.0 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOS19747.1 - 1.6e-14 54.2 0.0 3.7e-14 53.0 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS19747.1 - 6.2e-09 35.9 0.0 1.2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOS19747.1 - 4.1e-05 23.9 0.2 0.00012 22.3 0.1 1.8 2 0 0 2 2 1 1 AAA domain DUF2075 PF09848.9 KOS19747.1 - 0.0001 21.7 0.0 0.00024 20.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 KOS19747.1 - 0.0014 18.9 0.0 0.0033 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS19747.1 - 0.0015 18.2 0.0 0.0054 16.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KOS19747.1 - 0.0042 17.1 0.0 0.84 9.6 0.0 2.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ATPase PF06745.13 KOS19747.1 - 0.0058 16.0 0.0 0.013 14.8 0.0 1.5 1 0 0 1 1 1 1 KaiC T2SSE PF00437.20 KOS19747.1 - 0.0062 15.6 0.0 0.015 14.4 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Flavi_DEAD PF07652.14 KOS19747.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 Flavivirus DEAD domain ABC_tran PF00005.27 KOS19747.1 - 0.028 14.9 0.3 0.13 12.8 0.0 2.3 2 0 0 2 2 1 0 ABC transporter SRP54 PF00448.22 KOS19747.1 - 0.029 14.0 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PhoH PF02562.16 KOS19747.1 - 0.039 13.4 0.1 0.13 11.6 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 KOS19747.1 - 0.069 13.2 0.2 0.42 10.7 0.2 2.2 1 1 0 1 1 1 0 AAA domain GAD PF02938.14 KOS19747.1 - 0.1 12.9 0.0 0.28 11.5 0.0 1.7 1 0 0 1 1 1 0 GAD domain AAA_16 PF13191.6 KOS19747.1 - 0.13 12.7 0.0 0.3 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 KOS19747.1 - 0.15 11.6 0.0 0.32 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_33 PF13671.6 KOS19747.1 - 0.37 10.9 0.0 0.37 10.9 0.0 2.4 3 1 0 3 3 2 0 AAA domain Acylphosphatase PF00708.18 KOS19748.1 - 1.4e-22 79.9 0.0 1.5e-22 79.8 0.0 1.0 1 0 0 1 1 1 1 Acylphosphatase WD40 PF00400.32 KOS19749.1 - 5.4e-07 30.2 4.0 0.065 14.1 0.1 4.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 KOS19749.1 - 0.2 10.3 1.9 0.79 8.3 0.2 2.2 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Tim17 PF02466.19 KOS19752.1 - 2.8e-23 82.4 6.7 2.8e-23 82.4 6.7 1.8 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family BSP_II PF05432.11 KOS19754.1 - 0.54 9.9 12.2 0.9 9.2 12.2 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NOA36 PF06524.12 KOS19754.1 - 0.66 9.2 9.1 1.3 8.3 9.1 1.4 1 0 0 1 1 1 0 NOA36 protein SWIRM-assoc_2 PF16496.5 KOS19754.1 - 4.4 6.1 7.5 6.8 5.5 7.5 1.3 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal Complex1_LYR PF05347.15 KOS19755.1 - 4.7e-20 71.4 3.8 6.2e-20 71.0 3.8 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOS19755.1 - 1.7e-07 31.9 0.9 1.8e-07 31.8 0.9 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 KOS19755.1 - 0.00039 21.0 0.5 0.00051 20.6 0.5 1.2 1 0 0 1 1 1 1 Complex1_LYR-like PilP PF04351.13 KOS19755.1 - 0.008 16.1 0.2 0.01 15.8 0.2 1.0 1 0 0 1 1 1 1 Pilus assembly protein, PilP LCCL PF03815.19 KOS19758.1 - 4.1e-21 74.9 0.1 6.7e-21 74.2 0.1 1.3 1 0 0 1 1 1 1 LCCL domain Abhydrolase_2 PF02230.16 KOS19759.1 - 0.0039 17.0 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Asparaginase PF00710.20 KOS19760.1 - 1.1e-60 204.5 0.0 1.5e-60 204.0 0.0 1.2 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 KOS19760.1 - 3.3e-26 91.7 0.0 7.6e-26 90.6 0.0 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain Ank_2 PF12796.7 KOS19760.1 - 8.9e-16 58.3 1.8 7e-09 36.1 0.3 2.7 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS19760.1 - 4.2e-08 33.6 0.1 0.0019 18.8 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS19760.1 - 8.5e-07 28.8 0.1 0.03 14.9 0.0 4.4 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 KOS19760.1 - 1.2e-06 28.6 0.8 0.016 15.6 0.2 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOS19760.1 - 0.0017 18.6 0.6 0.046 14.1 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) USP7_ICP0_bdg PF12436.8 KOS19761.1 - 2.9e-83 278.9 0.0 9.1e-82 274.0 0.0 2.4 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 PF14533.6 KOS19761.1 - 2.8e-76 255.8 0.7 6e-74 248.2 0.7 3.6 3 1 1 4 4 4 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 KOS19761.1 - 1.5e-47 162.3 1.2 1.5e-47 162.3 1.2 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS19761.1 - 1.8e-23 83.6 0.0 4.3e-23 82.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 KOS19761.1 - 1.7e-09 37.8 0.0 6.5e-09 35.9 0.0 2.1 1 0 0 1 1 1 1 MATH domain YukD PF08817.10 KOS19761.1 - 0.0068 17.1 0.1 4 8.2 0.0 3.3 3 0 0 3 3 3 1 WXG100 protein secretion system (Wss), protein YukD Pkinase PF00069.25 KOS19763.1 - 6.3e-65 219.2 0.0 7.4e-65 218.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19763.1 - 3.8e-29 101.7 0.0 5.2e-29 101.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19763.1 - 0.0038 16.6 0.0 0.0086 15.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOS19763.1 - 0.015 14.1 0.0 0.022 13.5 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KOS19763.1 - 0.047 12.6 0.0 0.095 11.6 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 KOS19763.1 - 0.064 12.9 0.0 0.16 11.6 0.0 1.6 1 1 1 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Trypan_PARP PF05887.11 KOS19763.1 - 7.7 6.5 11.0 15 5.6 11.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PQ-loop PF04193.14 KOS19764.1 - 2.6e-15 55.9 0.6 8e-10 38.3 0.1 2.7 2 0 0 2 2 2 2 PQ loop repeat TGT PF01702.18 KOS19765.1 - 1e-62 212.3 0.0 2.8e-53 181.3 0.0 2.0 1 1 1 2 2 2 2 Queuine tRNA-ribosyltransferase 6PF2K PF01591.18 KOS19765.1 - 0.0022 17.3 0.0 0.0033 16.8 0.0 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase MTHFR PF02219.17 KOS19766.1 - 1.5e-95 319.8 0.0 8.1e-94 314.1 0.0 2.2 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase ORC6 PF05460.13 KOS19767.1 - 2.2 7.5 4.5 4.3 6.5 4.0 1.6 1 1 1 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Asp PF00026.23 KOS19768.1 - 9.1e-66 222.4 0.5 1.1e-65 222.1 0.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS19768.1 - 3.7e-11 43.6 2.6 3.6e-09 37.1 1.5 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOS19768.1 - 0.0085 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal PPTA PF01239.22 KOS19769.1 - 2.4e-09 36.6 10.0 0.016 14.9 0.5 4.4 4 0 0 4 4 4 3 Protein prenyltransferase alpha subunit repeat Nup192 PF11894.8 KOS19770.1 - 0 1545.7 0.0 0 1545.5 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 PI3_PI4_kinase PF00454.27 KOS19772.1 - 3e-51 174.7 0.0 5.6e-51 173.8 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 KOS19772.1 - 4.1e-12 45.7 0.1 1e-11 44.4 0.1 1.7 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 KOS19772.1 - 2.7e-11 43.3 0.0 6.3e-11 42.1 0.0 1.5 1 1 0 1 1 1 1 FAT domain Gln-synt_C PF00120.24 KOS19773.1 - 2e-15 56.6 0.0 5.4e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 KOS19773.1 - 4.7e-12 45.5 0.0 8.2e-12 44.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain Kinetochor_Ybp2 PF08568.10 KOS19774.1 - 5.5e-79 266.3 0.0 6.2e-53 180.3 0.0 2.0 2 0 0 2 2 2 2 Uncharacterised protein family, YAP/Alf4/glomulin DNApol_Exo PF18136.1 KOS19775.1 - 8.7e-69 231.8 0.4 1.5e-68 231.0 0.0 1.6 2 0 0 2 2 2 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 KOS19775.1 - 7.2e-55 186.6 0.0 1.5e-54 185.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A ABC_membrane PF00664.23 KOS19776.1 - 3.1e-108 361.6 36.9 2.1e-57 194.9 10.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOS19776.1 - 9.1e-69 230.3 0.9 4.7e-33 114.6 0.0 2.8 3 0 0 3 3 2 2 ABC transporter SMC_N PF02463.19 KOS19776.1 - 1.8e-14 53.7 0.0 1.5e-05 24.6 0.0 3.4 1 1 2 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS19776.1 - 2.9e-07 30.1 1.8 0.0015 18.2 0.4 3.1 3 0 0 3 3 3 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOS19776.1 - 1.6e-06 28.1 0.0 0.031 14.2 0.0 3.1 3 0 0 3 3 3 2 RsgA GTPase ABC_ATPase PF09818.9 KOS19776.1 - 1.2e-05 24.4 2.5 0.078 11.8 0.1 2.9 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_16 PF13191.6 KOS19776.1 - 1.4e-05 25.6 8.8 0.014 15.8 0.1 3.7 3 2 1 4 4 3 2 AAA ATPase domain AAA_22 PF13401.6 KOS19776.1 - 3.1e-05 24.3 1.4 0.49 10.7 0.0 3.8 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.6 KOS19776.1 - 6e-05 22.9 0.2 0.27 10.9 0.1 2.8 2 1 0 2 2 2 2 AAA ATPase domain AAA_25 PF13481.6 KOS19776.1 - 9.7e-05 22.0 0.1 0.35 10.4 0.1 2.9 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOS19776.1 - 0.0002 21.8 1.6 4.9 7.6 0.0 4.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOS19776.1 - 0.0011 18.7 1.5 3.3 7.4 0.1 3.7 4 0 0 4 4 4 2 AAA domain SbcCD_C PF13558.6 KOS19776.1 - 0.0018 18.5 1.0 4.5 7.6 0.1 3.6 2 2 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_21 PF13304.6 KOS19776.1 - 0.0018 18.1 0.2 2.8 7.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system G-alpha PF00503.20 KOS19776.1 - 0.005 16.0 0.0 2.9 7.0 0.0 2.3 2 0 0 2 2 2 2 G-protein alpha subunit Zeta_toxin PF06414.12 KOS19776.1 - 0.0077 15.5 0.0 4.7 6.4 0.0 2.8 2 0 0 2 2 2 1 Zeta toxin AAA_28 PF13521.6 KOS19776.1 - 0.0079 16.4 1.9 0.53 10.5 0.0 3.2 3 0 0 3 3 2 1 AAA domain AAA_5 PF07728.14 KOS19776.1 - 0.0095 15.9 0.3 10 6.2 0.0 3.3 4 0 0 4 4 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 KOS19776.1 - 0.014 15.6 0.0 9.7 6.3 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOS19776.1 - 0.014 14.9 0.0 3 7.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_18 PF13238.6 KOS19776.1 - 0.026 15.1 0.0 11 6.5 0.0 2.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 KOS19776.1 - 0.034 14.5 0.1 20 5.6 0.0 3.8 4 0 0 4 4 3 0 RNA helicase DUF87 PF01935.17 KOS19776.1 - 0.047 13.8 3.4 6 6.9 0.0 3.0 3 0 0 3 3 3 0 Helicase HerA, central domain Rad17 PF03215.15 KOS19776.1 - 0.11 12.5 0.0 1.1 9.2 0.0 2.3 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 KOS19776.1 - 0.12 12.9 3.3 4.6 7.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain SRP54 PF00448.22 KOS19776.1 - 0.16 11.6 2.0 4.6 6.8 0.0 3.0 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_24 PF13479.6 KOS19776.1 - 0.18 11.5 0.1 12 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 KOS19776.1 - 1.1 9.3 5.5 18 5.4 0.0 3.5 3 0 0 3 3 3 0 50S ribosome-binding GTPase zf-C3HC4_3 PF13920.6 KOS19777.1 - 3.2e-11 42.9 8.9 4.6e-11 42.4 8.9 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOS19777.1 - 7.6e-08 32.1 7.6 1.3e-07 31.4 7.6 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOS19777.1 - 2.4e-07 30.5 12.1 3.9e-07 29.8 12.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS19777.1 - 1.9e-06 28.1 10.0 2.9e-06 27.5 10.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 KOS19777.1 - 9.6e-06 25.4 11.1 1.5e-05 24.8 11.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS19777.1 - 2.3e-05 24.3 10.0 3.8e-05 23.5 10.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOS19777.1 - 3.6e-05 23.7 4.4 7.2e-05 22.8 4.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 KOS19777.1 - 0.00014 21.8 6.6 0.00031 20.7 6.6 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 KOS19777.1 - 0.0093 15.7 6.9 0.017 14.9 6.9 1.4 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 KOS19777.1 - 0.013 15.7 7.3 0.024 14.9 7.3 1.4 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 KOS19777.1 - 0.015 15.4 8.0 0.027 14.6 8.0 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 KOS19777.1 - 0.21 11.4 4.8 0.35 10.6 4.8 1.4 1 0 0 1 1 1 0 RING-like zinc finger DZR PF12773.7 KOS19777.1 - 2.2 8.4 5.7 4.8 7.3 5.7 1.6 1 0 0 1 1 1 0 Double zinc ribbon FANCL_C PF11793.8 KOS19777.1 - 5.4 7.3 8.7 5.6e+02 0.8 8.7 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain HEAT PF02985.22 KOS19778.1 - 2.3e-40 133.1 16.4 0.026 14.7 0.1 13.2 14 0 0 14 14 14 10 HEAT repeat HEAT_2 PF13646.6 KOS19778.1 - 1.1e-33 115.5 6.3 3.3e-10 40.2 0.0 8.1 4 2 4 8 8 8 7 HEAT repeats HEAT_EZ PF13513.6 KOS19778.1 - 4.6e-12 46.2 2.1 0.05 14.1 0.1 7.1 7 1 1 8 8 7 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 KOS19778.1 - 8.9e-12 45.5 4.2 0.006 17.2 0.1 7.7 4 1 4 9 9 9 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 KOS19778.1 - 3.5e-10 40.2 16.3 0.00017 21.6 0.1 6.3 4 2 3 8 8 8 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOS19778.1 - 1.5e-09 37.0 6.6 0.0026 16.4 0.1 4.8 4 1 1 5 5 5 3 Adaptin N terminal region RTP1_C1 PF10363.9 KOS19778.1 - 1.6e-07 31.5 4.5 0.08 13.1 0.1 5.5 4 1 1 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 KOS19778.1 - 9.5e-06 25.3 1.5 1.9 8.0 0.0 4.6 2 2 1 5 5 5 3 CLASP N terminal IFRD PF05004.13 KOS19778.1 - 0.027 13.6 0.7 2.6 7.0 0.1 3.4 3 1 0 3 3 3 0 Interferon-related developmental regulator (IFRD) Ecm29 PF13001.7 KOS19778.1 - 0.065 11.9 2.9 1.8 7.1 0.0 3.6 5 0 0 5 5 5 0 Proteasome stabiliser TetR_C_16 PF17920.1 KOS19778.1 - 0.091 13.0 0.3 24 5.2 0.0 3.3 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain RPA_interact_N PF14766.6 KOS19778.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Replication protein A interacting N-terminal Arm PF00514.23 KOS19778.1 - 0.48 10.5 5.9 4.4 7.5 0.0 4.2 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Proteasom_PSMB PF10508.9 KOS19778.1 - 0.7 8.3 5.7 0.54 8.7 0.1 2.4 2 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit M11L PF11099.8 KOS19778.1 - 0.87 9.8 4.3 25 5.1 0.0 3.9 2 1 0 4 4 4 0 Apoptosis regulator M11L like bZIP_2 PF07716.15 KOS19779.1 - 2.2e-07 30.8 14.3 6.9e-07 29.3 14.3 1.9 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 KOS19779.1 - 0.00039 20.5 15.4 0.00039 20.5 15.4 2.1 2 0 0 2 2 2 1 bZIP transcription factor bZIP_Maf PF03131.17 KOS19779.1 - 0.11 13.0 14.7 0.037 14.5 10.3 2.1 2 0 0 2 2 2 0 bZIP Maf transcription factor Swi3 PF07962.12 KOS19780.1 - 5.6e-18 64.7 0.1 1.2e-17 63.7 0.1 1.5 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 NOA36 PF06524.12 KOS19780.1 - 3.9 6.7 14.7 0.14 11.4 3.7 2.2 2 0 0 2 2 2 0 NOA36 protein Cwf_Cwc_15 PF04889.12 KOS19780.1 - 8.6 6.0 28.0 0.7 9.6 5.1 2.3 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Surfac_D-trimer PF09006.11 KOS19781.1 - 0.0028 17.5 2.8 0.12 12.2 0.4 3.1 2 1 1 3 3 3 1 Lung surfactant protein D coiled-coil trimerisation CdvA PF18822.1 KOS19781.1 - 0.0031 17.3 0.0 0.0059 16.4 0.0 1.5 1 0 0 1 1 1 1 CdvA-like coiled-coil domain TetR_C_35 PF18556.1 KOS19781.1 - 0.026 14.7 0.3 0.05 13.7 0.3 1.5 1 0 0 1 1 1 0 Bacterial Tetracyclin repressor, C-terminal domain MbeD_MobD PF04899.12 KOS19781.1 - 0.035 14.2 0.2 0.11 12.6 0.2 1.9 1 1 0 1 1 1 0 MbeD/MobD like eIF-6 PF01912.18 KOS19782.1 - 4e-81 271.1 0.9 5.6e-81 270.6 0.9 1.2 1 0 0 1 1 1 1 eIF-6 family p450 PF00067.22 KOS19783.1 - 9.2e-41 140.1 0.0 2.6e-37 128.7 0.0 2.0 2 0 0 2 2 2 2 Cytochrome P450 eIF-5_eIF-2B PF01873.17 KOS19785.1 - 7.5e-39 132.2 0.0 1.8e-38 131.0 0.0 1.6 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 KOS19785.1 - 1.4e-23 82.8 0.4 6.3e-23 80.7 0.5 2.1 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Pox_Ag35 PF03286.14 KOS19785.1 - 0.35 10.6 5.2 0.24 11.2 1.8 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Phasin PF05597.11 KOS19786.1 - 0.23 11.5 2.7 0.43 10.6 2.7 1.5 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Asp PF00026.23 KOS19787.1 - 1.3e-65 222.0 0.0 1.5e-65 221.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS19787.1 - 4.8e-12 46.5 0.7 3.6e-09 37.1 0.7 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOS19787.1 - 1.5e-05 25.5 3.0 0.0039 17.8 0.1 3.2 3 1 0 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 KOS19787.1 - 0.003 17.4 0.0 0.012 15.4 0.0 2.0 2 0 0 2 2 2 1 Xylanase inhibitor C-terminal DUF2076 PF09849.9 KOS19787.1 - 0.1 12.7 0.2 0.19 11.8 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Cnn_1N PF07989.11 KOS19788.1 - 4e-08 33.3 11.5 4e-08 33.3 11.5 1.9 2 0 0 2 2 2 1 Centrosomin N-terminal motif 1 TrwC PF08751.11 KOS19788.1 - 2.7 7.4 5.8 0.22 11.0 0.9 1.6 2 0 0 2 2 2 0 TrwC relaxase DivIC PF04977.15 KOS19788.1 - 9.1 6.1 9.9 0.93 9.3 0.9 2.7 1 1 2 3 3 3 0 Septum formation initiator PRKCSH PF07915.13 KOS19789.1 - 3.1e-16 60.1 0.0 9e-16 58.7 0.0 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein RNA_polI_A34 PF08208.11 KOS19789.1 - 0.64 10.1 8.1 1.3 9.1 8.1 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 zf-C2H2 PF00096.26 KOS19790.1 - 0.0009 19.6 1.6 0.0009 19.6 1.6 2.7 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS19790.1 - 0.0078 17.0 5.1 0.14 13.1 1.1 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 KOS19790.1 - 0.023 15.1 0.2 0.059 13.8 0.2 1.7 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-BED PF02892.15 KOS19790.1 - 0.26 11.3 1.8 0.25 11.4 0.3 1.8 2 0 0 2 2 2 0 BED zinc finger zf-C2H2 PF00096.26 KOS19791.1 - 7.2e-06 26.2 4.3 0.033 14.6 0.7 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS19791.1 - 0.00032 21.3 5.9 0.058 14.3 0.6 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_12 PF18658.1 KOS19791.1 - 0.0023 17.5 0.0 2.4 7.8 0.0 2.3 2 0 0 2 2 2 2 Zinc-finger C2H2-type MSA-2c PF12238.8 KOS19791.1 - 0.33 10.9 1.2 0.4 10.6 1.2 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Sld5 PF05916.11 KOS19793.1 - 2.4e-16 60.2 0.0 3.2e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 GINS complex protein Rxt3 PF08642.10 KOS19794.1 - 8.3e-41 139.7 1.4 1.2e-38 132.7 0.0 3.4 3 0 0 3 3 3 1 Histone deacetylation protein Rxt3 LCCL PF03815.19 KOS19794.1 - 0.00018 21.6 0.0 0.0019 18.3 0.0 2.3 2 0 0 2 2 2 1 LCCL domain Suf PF05843.14 KOS19794.1 - 9.5 6.1 21.9 2.3 8.1 8.7 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) SprT-like PF10263.9 KOS19796.1 - 1.2e-13 50.9 0.1 3e-13 49.6 0.0 1.7 2 0 0 2 2 2 1 SprT-like family Spore_YtfJ PF09579.10 KOS19796.1 - 0.13 12.5 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) F-box-like PF12937.7 KOS19797.1 - 4.5e-12 45.7 1.5 9.4e-12 44.6 1.5 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS19797.1 - 8.8e-10 38.2 1.3 1.7e-09 37.3 1.3 1.5 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 KOS19797.1 - 0.0085 16.0 0.1 0.016 15.1 0.1 1.4 1 0 0 1 1 1 1 F-box RhlB PF12300.8 KOS19797.1 - 0.2 11.8 3.2 0.22 11.6 0.3 2.3 2 0 0 2 2 2 0 ATP-dependent RNA helicase RhlB DUF3439 PF11921.8 KOS19797.1 - 1.5 8.8 7.9 3.1 7.8 7.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Cwf_Cwc_15 PF04889.12 KOS19797.1 - 5.5 6.6 15.4 0.52 10.0 7.4 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Epimerase PF01370.21 KOS19799.1 - 3.4e-10 39.8 0.1 2.7e-05 23.7 0.1 2.2 2 0 0 2 2 2 2 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS19799.1 - 0.00012 21.6 0.0 0.0094 15.4 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KOS19799.1 - 0.00042 19.9 0.1 0.00069 19.2 0.1 1.3 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOS19799.1 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KOS19799.1 - 0.0012 19.1 0.0 0.002 18.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 KOS19799.1 - 0.053 12.5 0.0 0.082 11.9 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 KOS19799.1 - 0.086 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 TrkA-N domain HSP70 PF00012.20 KOS19800.1 - 5.5e-224 744.8 6.9 6.2e-224 744.6 6.9 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS19800.1 - 5.8e-16 58.2 0.3 6e-15 54.9 0.1 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOS19800.1 - 0.0001 22.1 0.0 0.00021 21.1 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 KOS19800.1 - 0.012 14.7 0.8 0.063 12.3 0.1 2.3 2 1 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain RNA_pol_Rpb1_5 PF04998.17 KOS19803.1 - 8.1e-100 333.7 0.0 1.4e-99 332.9 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.12 KOS19803.1 - 6e-98 328.0 0.0 8.8e-97 324.2 0.0 2.2 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.20 KOS19803.1 - 2.1e-76 255.7 0.0 4.1e-76 254.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 KOS19803.1 - 2.7e-59 200.2 0.2 4.5e-59 199.5 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_7 PF04990.12 KOS19803.1 - 4.1e-47 159.6 9.7 8.9e-47 158.5 9.1 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_3 PF04983.18 KOS19803.1 - 1.5e-42 145.2 0.0 3e-42 144.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 KOS19803.1 - 3.7e-36 123.4 0.2 8.1e-36 122.2 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 TFR_dimer PF04253.15 KOS19804.1 - 7.1e-29 100.4 0.0 3.7e-28 98.1 0.0 2.0 2 0 0 2 2 2 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 KOS19804.1 - 1.4e-20 73.8 0.0 3.2e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 KOS19804.1 - 1.3e-09 37.9 0.1 6.9e-09 35.6 0.1 2.2 1 1 0 1 1 1 1 PA domain Nicastrin PF05450.15 KOS19804.1 - 0.0014 18.1 0.0 0.0028 17.2 0.0 1.4 1 0 0 1 1 1 1 Nicastrin MFS_1 PF07690.16 KOS19805.1 - 4.5e-35 121.2 31.3 7.4e-28 97.5 8.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS19805.1 - 2.5e-06 26.6 4.9 2.5e-06 26.6 4.9 3.3 2 2 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KOS19805.1 - 3.2e-05 22.6 0.9 6.7e-05 21.5 0.9 1.5 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Caps_synth PF05704.12 KOS19806.1 - 8.7e-12 45.0 0.0 1.8e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 KOS19806.1 - 3.7e-06 27.5 0.0 7.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif RNA_pol_Rpb1_5 PF04998.17 KOS19807.1 - 6e-72 242.3 0.1 1.3e-71 241.2 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 KOS19807.1 - 2.2e-68 229.7 1.0 4.3e-68 228.7 1.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 KOS19807.1 - 6.1e-23 81.5 0.0 2e-22 79.8 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 KOS19807.1 - 4.7e-18 65.6 3.6 4.2e-09 36.2 0.1 3.8 3 1 0 3 3 3 2 RNA polymerase Rpb1, domain 1 Nop14 PF04147.12 KOS19807.1 - 0.015 13.5 7.2 0.026 12.8 7.2 1.3 1 0 0 1 1 1 0 Nop14-like family ANAPC4_WD40 PF12894.7 KOS19808.1 - 0.0013 19.0 0.0 0.46 10.8 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS19808.1 - 0.0089 16.9 1.4 3.2 8.8 0.0 4.0 5 1 0 5 5 5 1 WD domain, G-beta repeat CNH PF00780.22 KOS19808.1 - 0.03 13.9 0.2 13 5.2 0.0 3.6 2 1 2 4 4 4 0 CNH domain Hira PF07569.11 KOS19808.1 - 0.16 11.7 0.0 0.8 9.4 0.0 2.1 2 0 0 2 2 2 0 TUP1-like enhancer of split DSPc PF00782.20 KOS19809.1 - 3.7e-27 94.7 0.0 1.2e-20 73.6 0.0 2.2 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOS19809.1 - 0.00032 20.3 0.0 0.0042 16.7 0.0 2.1 2 0 0 2 2 2 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 KOS19809.1 - 0.028 14.1 0.1 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 KOS19809.1 - 0.099 12.8 0.0 0.35 11.0 0.1 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate DEAD_2 PF06733.15 KOS19810.1 - 4.9e-57 192.4 0.3 9.1e-57 191.5 0.3 1.5 1 0 0 1 1 1 1 DEAD_2 HBB PF06777.11 KOS19810.1 - 2e-44 151.6 1.6 1.8e-40 138.7 0.4 2.4 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 KOS19810.1 - 8.3e-44 149.8 0.0 2.6e-43 148.2 0.0 1.9 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 KOS19810.1 - 5.3e-05 23.3 0.1 0.0017 18.4 0.1 2.3 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOS19810.1 - 0.0012 18.6 0.1 0.21 11.4 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase SNF2_N PF00176.23 KOS19810.1 - 0.0034 16.1 0.0 0.041 12.6 0.0 2.2 1 1 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 KOS19810.1 - 0.055 13.7 0.2 4.9 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain UvrD_C PF13361.6 KOS19810.1 - 0.089 12.1 0.4 0.15 11.4 0.4 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 KOS19810.1 - 0.12 11.6 0.1 4 6.6 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AtuA PF07287.11 KOS19811.1 - 9e-108 360.1 0.1 1.2e-107 359.7 0.1 1.1 1 0 0 1 1 1 1 Acyclic terpene utilisation family protein AtuA gag-asp_proteas PF13975.6 KOS19812.1 - 2.3e-16 60.1 0.0 3.1e-07 30.9 0.0 2.4 2 0 0 2 2 2 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KOS19812.1 - 8.5e-15 55.2 0.0 8.8e-07 29.5 0.0 2.4 2 0 0 2 2 2 2 Aspartyl protease Asp_protease PF09668.10 KOS19812.1 - 4.4e-08 32.9 0.0 0.0036 17.1 0.0 2.4 2 1 0 2 2 2 2 Aspartyl protease RVP_2 PF08284.11 KOS19812.1 - 0.00015 21.6 0.0 0.0078 16.0 0.0 2.5 2 1 0 2 2 2 1 Retroviral aspartyl protease RVP PF00077.20 KOS19812.1 - 0.00097 19.4 0.0 0.0064 16.8 0.0 2.2 2 1 0 2 2 2 1 Retroviral aspartyl protease DUF1758 PF05585.12 KOS19812.1 - 0.0073 16.1 0.0 0.17 11.7 0.0 2.7 3 0 0 3 3 3 1 Putative peptidase (DUF1758) SH3_4 PF06347.13 KOS19812.1 - 0.078 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain Chromo PF00385.24 KOS19814.1 - 5.2e-07 29.5 1.9 0.00016 21.5 0.0 2.6 2 1 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain TFIIA PF03153.13 KOS19814.1 - 0.59 10.1 7.4 0.8 9.6 7.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FYDLN_acid PF09538.10 KOS19814.1 - 4.7 7.9 15.1 1 10.1 8.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 KOS19814.1 - 7.9 4.4 8.7 12 3.9 8.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Ank_2 PF12796.7 KOS19815.1 - 5.8e-24 84.5 0.1 1.2e-11 45.0 0.3 2.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 KOS19815.1 - 1.2e-16 60.3 1.0 8.4e-06 26.0 0.1 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 KOS19815.1 - 1.4e-16 60.7 6.6 2.7e-07 31.0 0.4 3.8 1 1 3 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS19815.1 - 2.2e-15 56.5 5.5 5.6e-11 42.5 0.7 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS19815.1 - 1.5e-13 49.6 0.2 8e-05 22.8 0.0 3.8 3 0 0 3 3 3 3 Ankyrin repeat DUF669 PF05037.13 KOS19815.1 - 0.00041 20.5 0.0 0.00077 19.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF669) SesA PF17107.5 KOS19815.1 - 0.0078 16.4 0.1 0.016 15.4 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases YtxH PF12732.7 KOS19815.1 - 0.085 13.4 0.3 0.76 10.3 0.3 2.4 1 1 0 1 1 1 0 YtxH-like protein TPR_MLP1_2 PF07926.12 KOS19815.1 - 0.18 11.9 2.9 1 9.4 0.8 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Peptidase_M20 PF01546.28 KOS19816.1 - 5.2e-06 26.3 0.6 9.3e-06 25.5 0.6 1.7 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOS19816.1 - 0.011 15.6 0.0 0.031 14.2 0.0 1.7 1 1 0 1 1 1 0 Peptidase dimerisation domain zf-H2C2_2 PF13465.6 KOS19817.1 - 3.1e-07 30.5 8.6 0.0034 17.7 0.4 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 KOS19817.1 - 4e-05 23.8 3.3 4e-05 23.8 3.3 3.1 3 1 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 KOS19817.1 - 0.00012 22.3 3.9 0.00023 21.4 0.2 2.4 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 KOS19817.1 - 0.0003 21.4 2.8 0.0003 21.4 2.8 3.2 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2HC_2 PF13913.6 KOS19817.1 - 0.0046 16.8 1.4 0.0046 16.8 1.4 2.1 3 0 0 3 3 3 1 zinc-finger of a C2HC-type IBR PF01485.21 KOS19817.1 - 0.014 15.6 0.6 0.025 14.8 0.6 1.5 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Rad50_zn_hook PF04423.14 KOS19817.1 - 0.028 14.3 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_aberr PF17017.5 KOS19817.1 - 0.05 13.7 0.0 0.063 13.4 0.0 1.2 1 0 0 1 1 1 0 Aberrant zinc-finger ARS2 PF04959.13 KOS19817.1 - 0.14 12.5 0.7 0.14 12.5 0.7 1.7 2 0 0 2 2 2 0 Arsenite-resistance protein 2 zf-ACC PF17848.1 KOS19817.1 - 0.2 11.7 2.1 0.48 10.6 0.0 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-H2C2_5 PF13909.6 KOS19817.1 - 0.38 10.6 18.2 0.7 9.7 3.6 3.3 3 1 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_12 PF18658.1 KOS19817.1 - 0.58 9.8 2.7 0.91 9.1 0.1 2.4 3 0 0 3 3 3 0 Zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 KOS19817.1 - 7.3 7.0 6.4 1.2 9.6 0.5 2.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding polyprenyl_synt PF00348.17 KOS19818.1 - 2.5e-44 151.3 0.0 3.4e-44 150.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase MFS_1 PF07690.16 KOS19819.1 - 1.6e-16 60.2 18.7 2.4e-16 59.6 18.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DPBB_1 PF03330.18 KOS19820.1 - 1.4e-05 25.3 0.2 3.3e-05 24.1 0.2 1.7 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 KOS19820.1 - 0.0063 16.4 1.6 0.0091 15.8 1.6 1.5 1 1 0 1 1 1 1 Barwin family ParA PF10609.9 KOS19821.1 - 1.1e-77 260.8 0.0 1.4e-77 260.5 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_26 PF13500.6 KOS19821.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain Kinocilin PF15033.6 KOS19821.1 - 0.17 11.5 0.0 1.3 8.6 0.0 2.0 2 0 0 2 2 2 0 Kinocilin protein Tudor_3 PF18115.1 KOS19822.1 - 5.9e-07 29.2 0.0 1e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 KOS19822.1 - 0.00074 19.5 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4537) RP-C_C PF11800.8 KOS19822.1 - 0.0083 16.2 3.4 0.0083 16.2 3.4 1.6 2 0 0 2 2 2 1 Replication protein C C-terminal region GOLGA2L5 PF15070.6 KOS19822.1 - 0.015 14.0 7.1 0.024 13.3 7.1 1.2 1 0 0 1 1 1 0 Putative golgin subfamily A member 2-like protein 5 IL11 PF07400.11 KOS19822.1 - 0.019 14.6 1.5 0.028 14.1 1.5 1.2 1 0 0 1 1 1 0 Interleukin 11 Tyrosinase PF00264.20 KOS19822.1 - 0.036 14.3 3.5 2.8 8.1 0.3 2.1 1 1 1 2 2 2 0 Common central domain of tyrosinase Fungal_trans PF04082.18 KOS19824.1 - 2.5e-13 49.7 0.0 5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS19824.1 - 0.0038 17.3 6.4 0.0068 16.5 6.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Peptidase_C2 PF00648.21 KOS19825.1 - 5.5e-29 101.1 0.0 1.7e-15 56.8 0.0 2.1 2 0 0 2 2 2 2 Calpain family cysteine protease Fungal_trans PF04082.18 KOS19826.1 - 1.3e-09 37.4 1.3 3.8e-09 36.0 0.1 2.3 2 1 0 2 2 2 1 Fungal specific transcription factor domain PhyH PF05721.13 KOS19827.1 - 1e-09 39.0 0.0 1.7e-09 38.2 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AraC_binding PF02311.19 KOS19827.1 - 0.013 15.4 0.5 0.04 13.8 0.5 1.8 1 0 0 1 1 1 0 AraC-like ligand binding domain Aldedh PF00171.22 KOS19828.1 - 1.1e-139 465.9 0.0 1.3e-139 465.7 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Romo1 PF10247.9 KOS19828.1 - 2.5 8.5 5.6 0.83 10.1 2.2 1.9 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 Glyco_hydro_92 PF07971.12 KOS19829.1 - 8.1e-141 470.1 0.1 9.7e-141 469.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOS19829.1 - 2.8e-59 200.9 0.3 4.6e-59 200.2 0.3 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Ferric_reduct PF01794.19 KOS19830.1 - 7.5e-21 74.5 7.8 7.5e-21 74.5 7.8 2.8 2 1 1 3 3 3 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOS19830.1 - 7.6e-16 58.6 0.0 2.5e-13 50.4 0.0 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS19830.1 - 4.4e-09 36.4 0.1 0.0052 16.9 0.2 2.4 2 0 0 2 2 2 2 FAD-binding domain NAD_binding_1 PF00175.21 KOS19830.1 - 2.8e-05 24.7 0.0 6.1e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain CFEM PF05730.11 KOS19830.1 - 0.085 13.0 5.3 0.15 12.2 5.3 1.3 1 0 0 1 1 1 0 CFEM domain Aldedh PF00171.22 KOS19831.1 - 4.6e-122 407.9 0.0 6e-122 407.5 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Robl_LC7 PF03259.17 KOS19832.1 - 2.4e-09 36.8 0.2 8.3e-06 25.5 0.0 2.5 1 1 1 2 2 2 2 Roadblock/LC7 domain Ceramidase_alk PF04734.13 KOS19834.1 - 2.7e-217 722.4 0.0 3.3e-217 722.1 0.0 1.1 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 KOS19834.1 - 8.7e-57 191.6 0.1 1.3e-56 191.1 0.1 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal MFS_1 PF07690.16 KOS19835.1 - 3.7e-39 134.6 50.4 6.4e-39 133.9 49.6 1.9 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS19835.1 - 2.9e-14 52.4 29.6 4.6e-14 51.8 29.6 1.3 1 1 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF5337 PF17272.2 KOS19835.1 - 2 8.3 6.6 0.29 11.0 0.6 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5337) Usp PF00582.26 KOS19836.1 - 1.5e-22 80.7 6.1 4.2e-14 53.3 0.1 3.4 3 1 0 3 3 3 2 Universal stress protein family Ribosomal_S7 PF00177.21 KOS19837.1 - 1.1e-24 86.8 0.0 1.6e-24 86.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Piwi PF02171.17 KOS19838.1 - 7e-73 245.5 0.0 9.8e-73 245.0 0.0 1.2 1 0 0 1 1 1 1 Piwi domain ArgoN PF16486.5 KOS19838.1 - 2.1e-12 47.8 0.0 3.5e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of argonaute ArgoL2 PF16488.5 KOS19838.1 - 7.9e-11 42.1 0.0 3.6e-10 40.0 0.0 2.2 2 0 0 2 2 2 1 Argonaute linker 2 domain ArgoL1 PF08699.10 KOS19838.1 - 1.4e-09 37.5 0.1 3.6e-09 36.1 0.1 1.7 1 0 0 1 1 1 1 Argonaute linker 1 domain ArgoMid PF16487.5 KOS19838.1 - 0.00056 20.1 0.1 0.0019 18.4 0.1 1.9 1 0 0 1 1 1 1 Mid domain of argonaute Hydrolase_4 PF12146.8 KOS19841.1 - 0.00013 21.3 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS19841.1 - 0.0023 17.6 0.1 0.0079 15.9 0.1 1.8 2 1 0 2 2 2 1 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 KOS19841.1 - 0.18 10.2 0.0 0.27 9.7 0.0 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Glyco_hydro_115 PF15979.5 KOS19842.1 - 3.9e-112 375.1 0.3 2e-77 260.9 0.0 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 115 GH115_C PF17829.1 KOS19842.1 - 2.2e-36 125.3 0.0 3.5e-36 124.6 0.0 1.3 1 0 0 1 1 1 1 Gylcosyl hydrolase family 115 C-terminal domain S_layer_C PF05124.12 KOS19842.1 - 0.079 12.9 0.0 0.19 11.7 0.0 1.6 2 0 0 2 2 2 0 S-layer like family, C-terminal region Inv-AAD PF18785.1 KOS19843.1 - 8.4e-55 184.1 0.0 9.8e-55 183.9 0.0 1.0 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase dCMP_cyt_deam_1 PF00383.23 KOS19843.1 - 4.2e-12 45.8 0.0 6.8e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region APOBEC_N PF08210.11 KOS19843.1 - 0.009 15.9 0.0 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 APOBEC-like N-terminal domain OPT PF03169.15 KOS19844.1 - 3.7e-126 422.2 44.8 4.2e-126 422.1 44.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein Caps_synth PF05704.12 KOS19845.1 - 4.4e-21 75.5 0.0 7.6e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein Gly_transf_sug PF04488.15 KOS19845.1 - 2.6e-06 28.0 0.0 5.5e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif zf_C2HC_14 PF18574.1 KOS19846.1 - 0.021 14.6 2.2 0.051 13.4 2.2 1.7 1 0 0 1 1 1 0 C2HC Zing finger domain Ribosomal_L50 PF10501.9 KOS19847.1 - 3.4e-12 46.5 0.0 6.2e-12 45.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal subunit 39S Pex24p PF06398.11 KOS19848.1 - 2e-96 323.2 0.1 2.7e-96 322.8 0.1 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF4861 PF16153.5 KOS19848.1 - 0.026 13.5 0.0 0.086 11.8 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4861) DUF2009 PF09418.10 KOS19848.1 - 0.17 10.9 0.1 0.26 10.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2009) DUF5381 PF17353.2 KOS19849.1 - 0.037 13.8 3.7 0.062 13.0 3.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5381) Tir_receptor_C PF07489.11 KOS19849.1 - 0.13 12.2 5.8 0.15 12.0 5.8 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Ribosomal_L13e PF01294.18 KOS19850.1 - 1.6e-72 243.1 1.3 2.3e-72 242.6 1.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L13e COX14 PF14880.6 KOS19851.1 - 1.1e-19 70.0 0.4 1.1e-19 70.0 0.4 1.7 2 0 0 2 2 2 1 Cytochrome oxidase c assembly PRP4 PF08799.11 KOS19851.1 - 0.025 14.1 0.1 0.053 13.1 0.1 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like DAHP_synth_1 PF00793.20 KOS19853.1 - 1.6e-102 342.0 0.0 2e-102 341.8 0.0 1.1 1 0 0 1 1 1 1 DAHP synthetase I family p450 PF00067.22 KOS19855.1 - 1.8e-55 188.5 0.0 4.7e-55 187.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome P450 SWIRM PF04433.17 KOS19855.1 - 0.13 12.6 0.0 24 5.4 0.0 2.4 2 0 0 2 2 2 0 SWIRM domain CtIP_N PF10482.9 KOS19856.1 - 0.02 15.0 1.2 0.2 11.7 0.0 2.5 3 0 0 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain DUF4267 PF14087.6 KOS19856.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4267) IDO PF01231.18 KOS19857.1 - 2.1e-164 547.4 0.0 2.4e-164 547.2 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase Phage_antitermQ PF06530.12 KOS19857.1 - 0.0067 16.3 0.1 0.013 15.4 0.1 1.4 1 0 0 1 1 1 1 Phage antitermination protein Q DUF1864 PF08933.11 KOS19857.1 - 0.15 10.7 0.0 0.51 9.0 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) RNA_pol_Rpb2_6 PF00562.28 KOS19858.1 - 6.5e-125 417.2 0.3 1.2e-124 416.3 0.2 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOS19858.1 - 1.2e-51 175.2 0.0 4.2e-51 173.4 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 KOS19858.1 - 6.5e-46 156.4 0.0 1.4e-45 155.3 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 KOS19858.1 - 1.4e-33 115.2 0.1 3e-33 114.1 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 KOS19858.1 - 1.2e-25 89.4 0.1 3.8e-25 87.9 0.1 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KOS19858.1 - 2.8e-24 85.4 0.9 7.7e-24 84.0 0.9 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 KOS19858.1 - 1.5e-19 70.1 0.6 4.4e-19 68.5 0.2 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 4 PET117 PF15786.5 KOS19859.1 - 7.1e-26 90.3 2.8 8.2e-26 90.1 2.8 1.0 1 0 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial V-ATPase_G PF03179.15 KOS19860.1 - 5.1e-27 94.5 12.2 5.8e-27 94.3 12.2 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit RRF PF01765.19 KOS19860.1 - 0.052 13.5 8.3 0.07 13.1 8.3 1.1 1 0 0 1 1 1 0 Ribosome recycling factor YusW PF14039.6 KOS19860.1 - 0.057 13.9 4.4 0.076 13.5 4.0 1.4 1 1 0 1 1 1 0 YusW-like protein CTNNBL PF08216.11 KOS19861.1 - 1.8e-36 124.4 0.0 4e-36 123.3 0.0 1.6 1 0 0 1 1 1 1 Catenin-beta-like, Arm-motif containing nuclear RNase_T PF00929.24 KOS19863.1 - 6e-11 43.2 0.0 7.6e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Exonuclease SHNi-TPR PF10516.9 KOS19863.1 - 0.035 13.6 0.1 0.054 13.0 0.1 1.3 1 0 0 1 1 1 0 SHNi-TPR CK_II_beta PF01214.18 KOS19864.1 - 7.4e-74 247.5 0.0 1.6e-73 246.4 0.0 1.5 1 1 0 1 1 1 1 Casein kinase II regulatory subunit Spt5_N PF11942.8 KOS19864.1 - 0.088 13.8 10.3 0.11 13.4 3.6 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Cupin_8 PF13621.6 KOS19865.1 - 1.4e-21 77.4 0.0 1.7e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 KOS19865.1 - 0.00014 22.3 0.0 0.00026 21.4 0.0 1.5 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_2 PF07883.11 KOS19865.1 - 0.0032 17.1 0.0 0.009 15.7 0.0 1.6 2 0 0 2 2 2 1 Cupin domain Cupin_4 PF08007.12 KOS19865.1 - 0.013 15.0 0.1 0.029 13.8 0.0 1.6 2 0 0 2 2 2 0 Cupin superfamily protein AraC_binding PF02311.19 KOS19865.1 - 0.14 12.1 0.1 1 9.2 0.0 2.1 2 0 0 2 2 2 0 AraC-like ligand binding domain Pro-kuma_activ PF09286.11 KOS19866.1 - 4.4e-43 147.0 0.0 8.1e-43 146.1 0.0 1.4 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 KOS19866.1 - 3.1e-06 26.7 2.3 5.7e-06 25.8 2.3 1.3 1 0 0 1 1 1 1 Subtilase family Copper-fist PF00649.18 KOS19867.1 - 4.3e-22 77.3 2.3 4.3e-22 77.3 2.3 4.3 2 1 1 4 4 4 1 Copper fist DNA binding domain Fungal_trans PF04082.18 KOS19868.1 - 0.00013 21.1 0.1 0.00042 19.4 0.1 1.9 1 0 0 1 1 1 1 Fungal specific transcription factor domain bZIP_1 PF00170.21 KOS19868.1 - 0.037 14.1 2.2 0.07 13.2 2.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor Zn_clus PF00172.18 KOS19868.1 - 1.5 9.0 4.3 2.4 8.3 4.3 1.3 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 KOS19868.1 - 2.7 7.9 22.1 4.5 7.2 22.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Methyltransf_25 PF13649.6 KOS19869.1 - 2.2e-08 34.7 0.0 5.2e-08 33.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS19869.1 - 2.2e-06 27.6 0.0 2.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS19869.1 - 0.00011 22.8 0.0 0.00028 21.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS19869.1 - 0.00013 22.7 0.0 0.00021 22.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain AdoMet_MTase PF07757.13 KOS19869.1 - 0.13 12.6 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase Cellulase PF00150.18 KOS19870.1 - 1.1e-13 51.3 0.2 1.1e-13 51.3 0.2 1.6 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) Rtf2 PF04641.12 KOS19873.1 - 1.2e-49 169.0 6.6 5.4e-49 166.9 6.6 2.0 1 1 0 1 1 1 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 KOS19873.1 - 0.00054 19.8 0.1 0.0014 18.5 0.1 1.7 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOS19873.1 - 0.0016 18.3 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn-ribbon_8 PF09723.10 KOS19873.1 - 0.0044 17.1 1.2 0.011 15.8 1.2 1.6 1 0 0 1 1 1 1 Zinc ribbon domain zf-RING_UBOX PF13445.6 KOS19873.1 - 0.0048 16.9 0.0 0.012 15.6 0.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOS19873.1 - 0.0065 16.8 0.1 0.012 16.0 0.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOS19873.1 - 0.013 15.4 0.4 0.023 14.5 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS19873.1 - 0.016 15.0 0.7 0.045 13.5 0.1 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_4 PF14570.6 KOS19873.1 - 0.058 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF3959 PF13105.6 KOS19873.1 - 0.32 10.5 1.3 0.45 10.0 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Vfa1 PF08432.10 KOS19873.1 - 0.33 11.3 12.6 0.5 10.7 12.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 KOS19873.1 - 0.63 9.8 6.2 0.92 9.2 6.2 1.2 1 0 0 1 1 1 0 Connexin RPN2_C PF18004.1 KOS19873.1 - 3.2 7.6 15.5 5.1 7.0 15.5 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 KOS19873.1 - 5.4 6.7 8.7 8.7 6.0 8.7 1.3 1 0 0 1 1 1 0 FAM176 family Yip1 PF04893.17 KOS19874.1 - 4.6e-08 33.0 13.7 6.2e-05 22.8 9.1 2.3 2 0 0 2 2 2 2 Yip1 domain RCC1 PF00415.18 KOS19875.1 - 7e-66 218.7 4.1 2.2e-12 47.4 0.2 7.4 7 0 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOS19875.1 - 4.5e-40 134.7 29.2 2.3e-10 40.0 1.0 6.7 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat Methyltransf_23 PF13489.6 KOS19876.1 - 2.2e-19 69.9 0.0 3.3e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19876.1 - 2.5e-11 44.1 0.0 5.9e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS19876.1 - 8.1e-09 36.0 0.0 6.6e-08 33.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS19876.1 - 2.1e-07 30.9 0.0 3.8e-06 26.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS19876.1 - 2.6e-05 24.9 0.0 0.00019 22.1 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 KOS19876.1 - 0.026 14.1 0.0 0.091 12.3 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase small domain FtsJ PF01728.19 KOS19876.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 FtsJ-like methyltransferase PrmA PF06325.13 KOS19876.1 - 0.2 11.0 0.0 0.31 10.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) D-ser_dehydrat PF14031.6 KOS19878.1 - 2.8e-22 79.2 0.2 6.1e-22 78.1 0.2 1.6 1 0 0 1 1 1 1 Putative serine dehydratase domain Ala_racemase_N PF01168.20 KOS19878.1 - 3.7e-11 43.1 4.3 1e-07 31.8 1.4 2.3 2 0 0 2 2 2 2 Alanine racemase, N-terminal domain TrkA_C PF02080.21 KOS19878.1 - 0.018 14.8 0.0 0.044 13.6 0.0 1.6 1 0 0 1 1 1 0 TrkA-C domain PAP_assoc PF03828.19 KOS19879.1 - 1e-11 44.8 0.0 1.9e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 KOS19879.1 - 5.7e-08 33.0 0.0 1.3e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain LRRNT_2 PF08263.12 KOS19879.1 - 0.0092 16.3 0.3 0.025 14.9 0.3 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain DUF4611 PF15387.6 KOS19879.1 - 8.9 6.6 12.0 18 5.6 6.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Fungal_trans PF04082.18 KOS19880.1 - 4.3e-11 42.3 4.0 4.5e-11 42.3 0.0 2.6 3 1 1 4 4 4 2 Fungal specific transcription factor domain MFS_1 PF07690.16 KOS19881.1 - 1.3e-30 106.5 29.1 2.2e-30 105.8 27.4 1.8 1 1 1 2 2 2 2 Major Facilitator Superfamily Pertus-S4-tox PF09275.10 KOS19881.1 - 0.097 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Pertussis toxin S4 subunit 4HBT PF03061.22 KOS19882.1 - 6.2e-07 29.7 0.7 1e-06 29.0 0.1 1.6 2 0 0 2 2 2 1 Thioesterase superfamily 4HBT_2 PF13279.6 KOS19882.1 - 3.8e-05 24.2 0.0 4.5e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Glyoxalase_5 PF14696.6 KOS19882.1 - 0.051 13.8 0.0 0.062 13.5 0.0 1.1 1 0 0 1 1 1 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Glyco_hydro_71 PF03659.14 KOS19884.1 - 7.3e-121 403.5 7.2 8.6e-121 403.3 7.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 71 NAD_kinase PF01513.21 KOS19884.1 - 0.061 12.5 0.1 0.092 11.9 0.1 1.2 1 0 0 1 1 1 0 ATP-NAD kinase p450 PF00067.22 KOS19885.1 - 1.4e-33 116.4 0.0 1.8e-33 116.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF3021 PF11457.8 KOS19886.1 - 0.024 15.0 1.5 0.052 13.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) Trp_DMAT PF11991.8 KOS19887.1 - 2e-83 280.8 0.0 2.3e-83 280.6 0.0 1.0 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase p450 PF00067.22 KOS19888.1 - 5.3e-36 124.3 0.0 6.5e-36 124.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glycophorin_A PF01102.18 KOS19888.1 - 0.038 14.2 0.1 0.082 13.2 0.1 1.6 1 0 0 1 1 1 0 Glycophorin A Glyco_hydro_127 PF07944.12 KOS19889.1 - 0.013 14.0 0.0 0.016 13.7 0.0 1.2 1 0 0 1 1 1 0 Beta-L-arabinofuranosidase, GH127 DUF905 PF06006.12 KOS19889.1 - 0.11 12.5 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) Pyr_redox_2 PF07992.14 KOS19890.1 - 1.7e-48 165.4 2.4 2.9e-48 164.6 2.4 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rieske PF00355.26 KOS19890.1 - 9.6e-16 57.5 0.0 2.2e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Pyr_redox PF00070.27 KOS19890.1 - 5.4e-13 49.3 3.8 7.1e-11 42.5 0.7 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS19890.1 - 1.3e-06 27.9 0.0 0.0071 15.6 0.0 2.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Reductase_C PF14759.6 KOS19890.1 - 1.9e-05 25.1 0.0 6.8e-05 23.3 0.0 2.0 1 0 0 1 1 1 1 Reductase C-terminal Rieske_2 PF13806.6 KOS19890.1 - 5e-05 23.2 0.0 0.00019 21.4 0.0 2.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NAD_binding_9 PF13454.6 KOS19890.1 - 0.00057 19.9 4.6 0.48 10.4 0.0 3.3 2 1 1 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOS19890.1 - 0.0007 18.8 0.1 0.044 12.9 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) PKHD_C PF18331.1 KOS19891.1 - 0.045 13.8 0.6 14 5.8 0.1 2.9 2 0 0 2 2 2 0 PKHD-type hydroxylase C-terminal domain Bacillus_HBL PF05791.11 KOS19891.1 - 5.5 6.8 7.8 0.59 9.9 1.4 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) IMUP PF15761.5 KOS19893.1 - 1.5 9.5 6.9 2.5 8.8 6.9 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein AF-4 PF05110.13 KOS19893.1 - 5.8 4.9 9.2 6.8 4.6 9.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Glyco_hydro_18 PF00704.28 KOS19894.1 - 1.4e-77 261.5 0.8 1.6e-77 261.3 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 p450 PF00067.22 KOS19895.1 - 2.5e-20 72.7 0.2 1.9e-15 56.6 0.2 2.0 1 1 1 2 2 2 2 Cytochrome P450 Pyr_redox_2 PF07992.14 KOS19896.1 - 2.2e-08 33.7 0.0 3.4e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS19896.1 - 0.037 13.6 0.5 0.08 12.5 0.3 1.6 2 0 0 2 2 2 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOS19896.1 - 0.068 13.2 0.0 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 FAD-NAD(P)-binding OTT_1508_deam PF14441.6 KOS19897.1 - 1.9e-11 43.8 0.0 4.1e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 OTT_1508-like deaminase Fe_dep_repr_C PF02742.15 KOS19897.1 - 0.13 12.3 1.0 0.27 11.3 0.3 1.9 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain Hexapep PF00132.24 KOS19898.1 - 7.3e-16 57.2 9.2 2.9e-12 45.8 3.6 3.5 3 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 KOS19898.1 - 1.9e-15 56.8 0.0 2.9e-15 56.2 0.0 1.3 1 0 0 1 1 1 1 Maltose acetyltransferase Hexapep_2 PF14602.6 KOS19898.1 - 6.5e-13 48.2 11.2 3.9e-12 45.7 2.9 3.8 4 0 0 4 4 4 1 Hexapeptide repeat of succinyl-transferase Subtilosin_A PF11420.8 KOS19898.1 - 0.22 11.5 0.1 0.22 11.5 0.1 1.8 2 0 0 2 2 2 0 Bacteriocin subtilosin A Ank_2 PF12796.7 KOS19899.1 - 1.2e-20 73.9 0.0 2.2e-10 41.0 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOS19899.1 - 2.9e-17 62.2 0.4 0.0009 19.6 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 KOS19899.1 - 2.8e-16 59.6 0.2 2.5e-09 37.5 0.0 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS19899.1 - 7e-15 53.7 0.0 0.024 15.1 0.0 4.8 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 KOS19899.1 - 2.1e-13 50.2 0.3 0.00057 20.1 0.0 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) HET PF06985.11 KOS19899.1 - 1e-10 42.1 8.1 1.7e-08 34.9 0.0 3.5 2 1 1 3 3 3 2 Heterokaryon incompatibility protein (HET) DivIC PF04977.15 KOS19899.1 - 0.81 9.5 14.2 1.8 8.4 0.6 3.5 3 0 0 3 3 3 0 Septum formation initiator CBM_14 PF01607.24 KOS19900.1 - 0.0059 16.7 16.0 0.22 11.7 1.4 4.1 1 1 2 3 3 3 3 Chitin binding Peritrophin-A domain Rubredoxin_2 PF18073.1 KOS19900.1 - 0.21 11.3 9.1 0.47 10.2 0.2 3.3 3 0 0 3 3 3 0 Rubredoxin metal binding domain TIL PF01826.17 KOS19900.1 - 0.54 10.6 20.6 0.78 10.0 9.4 3.5 1 1 2 3 3 3 0 Trypsin Inhibitor like cysteine rich domain ADH_N PF08240.12 KOS19901.1 - 7e-26 90.2 1.4 1.6e-25 89.1 1.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_assoc PF13823.6 KOS19901.1 - 5.1e-08 32.7 0.1 1.6e-07 31.1 0.1 1.9 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-associated ADH_zinc_N PF00107.26 KOS19901.1 - 4.9e-06 26.6 0.1 0.0074 16.3 0.0 2.6 3 0 0 3 3 3 2 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS19901.1 - 0.055 12.9 0.0 1.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus Rft-1 PF04506.13 KOS19902.1 - 3e-151 504.7 13.7 3.4e-151 504.5 13.7 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt PF01943.17 KOS19902.1 - 1.5e-07 31.1 11.4 1.5e-07 31.1 11.4 2.5 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_3 PF13440.6 KOS19902.1 - 2.2e-07 30.4 8.0 2.2e-07 30.4 8.0 3.2 3 1 0 3 3 3 1 Polysaccharide biosynthesis protein SurE PF01975.17 KOS19903.1 - 1.9e-41 142.0 0.0 3.3e-41 141.2 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ANAPC4_WD40 PF12894.7 KOS19904.1 - 2.1e-05 24.7 0.0 0.0051 17.1 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS19904.1 - 4.2e-05 22.7 1.1 0.1 11.6 0.0 3.1 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein SBP56 PF05694.11 KOS19904.1 - 0.048 12.5 0.0 0.12 11.2 0.0 1.6 2 0 0 2 2 2 0 56kDa selenium binding protein (SBP56) PQQ PF01011.21 KOS19904.1 - 0.065 13.2 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 PQQ enzyme repeat DUF1084 PF06454.11 KOS19904.1 - 0.16 11.3 0.2 0.3 10.4 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1084) Abhydrolase_1 PF00561.20 KOS19905.1 - 1e-07 31.8 0.1 1.6e-06 28.0 0.1 2.0 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS19905.1 - 0.014 14.6 0.1 0.023 13.9 0.1 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 KOS19905.1 - 2.1 8.9 16.3 2.4 8.7 13.3 2.1 1 1 1 2 2 2 0 Alpha/beta hydrolase family Tfb2 PF03849.14 KOS19907.1 - 2e-138 461.2 0.0 2.4e-138 461.0 0.0 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 KOS19907.1 - 2.3e-20 72.8 1.7 4.4e-20 71.9 1.7 1.5 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 KOS19907.1 - 3e-05 24.2 0.1 7.2e-05 22.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF829 PF05705.14 KOS19908.1 - 2.9e-20 73.2 0.0 3.5e-20 72.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Fungal_KA1 PF16797.5 KOS19911.1 - 8.3e-42 141.6 1.5 1e-41 141.3 0.7 1.6 2 0 0 2 2 2 1 Fungal kinase associated-1 domain HTH_ABP1_N PF18107.1 KOS19911.1 - 0.059 13.1 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Patatin PF01734.22 KOS19913.1 - 3.6e-15 56.7 0.0 1e-14 55.2 0.0 1.8 1 1 0 1 1 1 1 Patatin-like phospholipase GFO_IDH_MocA PF01408.22 KOS19914.1 - 2.3e-16 60.7 0.0 4.8e-16 59.7 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 KOS19914.1 - 0.0028 17.7 0.0 0.0098 15.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain SUIM_assoc PF16619.5 KOS19915.1 - 0.00043 20.3 0.0 0.0019 18.2 0.0 2.1 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF4763 PF15960.5 KOS19915.1 - 0.0018 17.6 0.5 0.0018 17.6 0.5 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF4763) Mce4_CUP1 PF11887.8 KOS19915.1 - 0.0046 16.5 0.2 0.0062 16.0 0.2 1.2 1 0 0 1 1 1 1 Cholesterol uptake porter CUP1 of Mce4, putative SHE3 PF17078.5 KOS19915.1 - 0.072 12.8 4.2 0.15 11.7 4.2 1.5 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 NBD94 PF16830.5 KOS19915.1 - 0.097 13.1 0.0 0.19 12.1 0.0 1.5 1 0 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH TMPIT PF07851.13 KOS19915.1 - 0.13 11.5 1.3 0.42 9.8 0.3 2.0 1 1 1 2 2 2 0 TMPIT-like protein LMBR1 PF04791.16 KOS19915.1 - 0.26 10.1 2.8 0.36 9.7 2.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein SOGA PF11365.8 KOS19915.1 - 0.79 10.9 4.7 0.94 10.7 2.1 2.6 1 1 1 2 2 2 0 Protein SOGA CENP-Q PF13094.6 KOS19915.1 - 6.4 7.0 14.9 11 6.1 9.2 3.0 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Peptidase_C14 PF00656.22 KOS19917.1 - 0.006 16.6 0.0 0.02 14.8 0.0 1.7 1 1 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 KOS19917.1 - 0.075 13.0 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain zf-C2H2 PF00096.26 KOS19917.1 - 0.15 12.6 18.1 0.18 12.3 1.5 4.6 4 1 0 4 4 4 0 Zinc finger, C2H2 type Sina PF03145.16 KOS19917.1 - 0.29 11.1 3.3 0.48 10.3 3.3 1.3 1 0 0 1 1 1 0 Seven in absentia protein family zf-C2H2_4 PF13894.6 KOS19917.1 - 0.66 11.0 19.3 0.13 13.2 1.5 4.6 4 1 0 4 4 4 0 C2H2-type zinc finger SlyX PF04102.12 KOS19917.1 - 2.1 9.0 6.2 1.1 10.0 0.1 2.4 2 0 0 2 2 2 0 SlyX Glyco_hydro_31 PF01055.26 KOS19918.1 - 1.5e-159 531.9 1.8 2e-159 531.5 1.8 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 NtCtMGAM_N PF16863.5 KOS19918.1 - 1.3e-38 131.7 0.1 2.3e-38 130.9 0.1 1.4 1 0 0 1 1 1 1 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase Gal_mutarotas_2 PF13802.6 KOS19918.1 - 2.8e-14 53.2 0.4 2.8e-14 53.2 0.4 3.3 3 0 0 3 3 3 1 Galactose mutarotase-like Malate_synthase PF01274.22 KOS19919.1 - 8.2e-219 727.2 0.0 1e-218 726.9 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 KOS19919.1 - 0.0078 15.4 0.0 0.019 14.1 0.0 1.6 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family S4 PF01479.25 KOS19919.1 - 0.058 13.1 0.0 6.8 6.5 0.0 2.5 2 0 0 2 2 2 0 S4 domain RRM_1 PF00076.22 KOS19921.1 - 2.9e-08 33.4 0.1 6.1e-08 32.4 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS19921.1 - 0.00088 19.2 0.0 0.0024 17.8 0.0 1.7 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KOS19921.1 - 0.033 14.0 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif ADIP PF11559.8 KOS19922.1 - 0.00037 20.6 2.8 0.00047 20.3 2.8 1.1 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CortBP2 PF09727.9 KOS19922.1 - 0.0023 17.9 2.1 0.0029 17.5 2.1 1.0 1 0 0 1 1 1 1 Cortactin-binding protein-2 Atg14 PF10186.9 KOS19922.1 - 0.062 12.4 2.1 0.07 12.2 2.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HAUS-augmin3 PF14932.6 KOS19922.1 - 0.43 10.1 4.2 0.56 9.7 4.1 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2046 PF09755.9 KOS19923.1 - 0.009 15.3 2.3 0.021 14.1 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized conserved protein H4 (DUF2046) DUF5115 PF17142.4 KOS19923.1 - 0.024 14.3 0.9 0.17 11.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5115) Striatin PF08232.12 KOS19923.1 - 0.23 12.0 4.2 0.54 10.9 0.1 2.3 2 0 0 2 2 2 0 Striatin family SPX PF03105.19 KOS19923.1 - 2.4 8.0 0.0 2.4 8.0 0.0 2.6 2 1 0 2 2 2 0 SPX domain GreA_GreB_N PF03449.15 KOS19923.1 - 4.1 7.6 7.5 0.44 10.7 3.1 1.7 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal TFIIA PF03153.13 KOS19923.1 - 5.8 6.8 9.1 7.8 6.4 9.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAA_hydrolase PF01557.18 KOS19924.1 - 2.5e-54 184.3 0.0 3.4e-54 183.8 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 KOS19924.1 - 7.9e-28 96.8 0.0 1.4e-27 96.0 0.0 1.4 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal TRAUB PF08164.12 KOS19925.1 - 2e-29 101.9 0.8 7e-29 100.2 0.3 2.3 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 KOS19925.1 - 1.9e-25 90.2 0.1 1.9e-25 90.2 0.1 3.5 2 1 0 3 3 3 1 Apoptosis antagonizing transcription factor TMEM51 PF15345.6 KOS19925.1 - 3.5 7.4 10.9 0.28 11.0 0.5 2.6 2 0 0 2 2 2 0 Transmembrane protein 51 Raptor_N PF14538.6 KOS19926.1 - 2e-64 216.0 0.0 3.7e-64 215.1 0.0 1.5 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 KOS19926.1 - 3.3e-07 30.9 2.7 1.6 9.7 0.0 5.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS19926.1 - 1.3e-05 25.4 0.0 1.2 9.5 0.2 4.7 2 2 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 KOS19926.1 - 1.3e-05 25.1 0.1 0.18 11.9 0.1 2.7 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Atx10homo_assoc PF09759.9 KOS19926.1 - 0.00045 20.2 0.3 0.00098 19.1 0.3 1.5 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain HEAT_2 PF13646.6 KOS19926.1 - 0.0082 16.5 0.1 6.1 7.3 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 KOS19926.1 - 0.069 13.4 1.2 3.1 8.3 0.1 4.3 6 0 0 6 6 6 0 HEAT repeat IKI3 PF04762.12 KOS19926.1 - 0.097 10.6 0.0 0.14 10.1 0.0 1.2 1 0 0 1 1 1 0 IKI3 family Kelch_4 PF13418.6 KOS19927.1 - 2.8e-32 110.5 12.1 5.2e-06 26.4 0.4 6.5 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_3 PF13415.6 KOS19927.1 - 4.9e-29 100.0 10.2 1.1e-08 35.1 0.1 6.2 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_5 PF13854.6 KOS19927.1 - 3.5e-28 97.1 5.9 3.4e-08 33.3 0.2 6.5 6 0 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 KOS19927.1 - 9.9e-27 92.3 7.9 6.6e-12 45.3 0.4 6.4 5 1 1 6 6 6 4 Kelch motif Kelch_1 PF01344.25 KOS19927.1 - 9.4e-24 82.7 3.7 2.8e-10 39.6 0.1 6.0 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 KOS19927.1 - 1.3e-20 72.4 6.5 2.1e-07 30.6 0.2 6.4 6 0 0 6 6 6 5 Kelch motif Pox_A_type_inc PF04508.12 KOS19927.1 - 0.92 9.5 8.4 3.8 7.5 0.5 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat K_channel_TID PF07941.11 KOS19928.1 - 8.5 6.9 17.2 1.1 9.7 6.0 2.9 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain VHS PF00790.19 KOS19929.1 - 1.3e-40 138.5 1.1 2.5e-39 134.3 0.0 2.2 2 0 0 2 2 2 1 VHS domain FYVE PF01363.21 KOS19929.1 - 1.3e-16 60.5 1.7 2.1e-16 59.8 1.7 1.3 1 0 0 1 1 1 1 FYVE zinc finger UIM PF02809.20 KOS19929.1 - 8.6e-06 25.3 17.9 0.0013 18.5 1.7 3.2 3 0 0 3 3 3 2 Ubiquitin interaction motif GAT PF03127.14 KOS19929.1 - 6.9e-05 23.1 0.0 0.00015 22.0 0.0 1.6 1 0 0 1 1 1 1 GAT domain FYVE_2 PF02318.16 KOS19929.1 - 0.02 15.1 0.1 0.041 14.1 0.1 1.5 1 0 0 1 1 1 0 FYVE-type zinc finger C1_1 PF00130.22 KOS19929.1 - 0.12 12.3 3.0 0.23 11.4 3.0 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Ribosomal_S30AE PF02482.19 KOS19929.1 - 0.23 12.3 0.1 2 9.3 0.7 2.2 2 0 0 2 2 2 0 Sigma 54 modulation protein / S30EA ribosomal protein DZR PF12773.7 KOS19929.1 - 0.28 11.2 2.9 0.62 10.1 2.9 1.5 1 0 0 1 1 1 0 Double zinc ribbon zf-RING_2 PF13639.6 KOS19929.1 - 0.47 10.8 3.2 0.84 10.0 3.2 1.4 1 0 0 1 1 1 0 Ring finger domain UCH PF00443.29 KOS19930.1 - 4.5e-33 114.8 0.0 7.2e-33 114.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS19930.1 - 2.2e-12 47.2 0.6 3.6e-11 43.2 0.2 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 KOS19930.1 - 4.6e-06 27.1 0.0 1e-05 26.0 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Cytochrome_C7 PF14522.6 KOS19930.1 - 0.035 14.1 0.0 0.083 12.9 0.0 1.6 1 0 0 1 1 1 0 Cytochrome c7 and related cytochrome c AMP-binding PF00501.28 KOS19931.1 - 3.5e-86 289.4 0.0 8e-86 288.3 0.0 1.5 2 0 0 2 2 2 1 AMP-binding enzyme NTP_transferase PF00483.23 KOS19932.1 - 7.2e-51 173.2 0.0 1.6e-50 172.0 0.0 1.5 2 0 0 2 2 2 1 Nucleotidyl transferase Hexapep PF00132.24 KOS19932.1 - 4.5e-17 61.0 10.1 6.3e-11 41.6 0.9 4.1 2 2 2 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 KOS19932.1 - 4.3e-09 36.9 0.0 6.3e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep_2 PF14602.6 KOS19932.1 - 3.5e-06 26.7 2.3 3.5e-06 26.7 2.3 4.0 4 2 1 5 5 5 1 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 KOS19932.1 - 0.009 14.2 0.0 0.027 12.6 0.0 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4954) CTP_transf_3 PF02348.19 KOS19932.1 - 0.038 13.9 0.0 0.096 12.6 0.0 1.6 2 0 0 2 2 2 0 Cytidylyltransferase Prenyltrans PF00432.21 KOS19933.1 - 4.8e-30 103.0 27.4 1.5e-08 34.3 0.9 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_N PF13249.6 KOS19933.1 - 0.14 11.2 0.3 10 5.1 0.1 2.2 1 1 1 2 2 2 0 Squalene-hopene cyclase N-terminal domain BRAP2 PF07576.12 KOS19935.1 - 9.7e-28 96.3 0.0 1.7e-27 95.5 0.0 1.3 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 KOS19935.1 - 8e-18 64.5 9.2 2.2e-17 63.1 9.2 1.7 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 KOS19935.1 - 1.2e-08 35.2 9.5 1.2e-08 35.2 9.5 2.4 3 0 0 3 3 1 1 Ring finger domain zf-RING_11 PF17123.5 KOS19935.1 - 2.7e-07 30.2 7.2 9.8e-07 28.4 5.6 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOS19935.1 - 9e-06 25.4 9.7 2.8e-05 23.9 9.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS19935.1 - 3.2e-05 23.8 7.5 3.2e-05 23.8 7.5 2.4 3 0 0 3 3 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOS19935.1 - 6.8e-05 22.8 7.9 0.00036 20.5 6.7 2.7 2 1 1 3 3 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOS19935.1 - 0.00012 21.9 8.7 0.00012 21.9 8.7 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS19935.1 - 0.00034 20.4 6.7 0.00034 20.4 6.7 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS19935.1 - 0.00072 19.8 6.8 0.0023 18.2 6.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOS19935.1 - 0.011 15.6 11.3 0.011 15.6 11.3 3.1 3 1 1 4 4 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 KOS19935.1 - 0.012 15.5 3.7 0.032 14.1 3.7 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-ANAPC11 PF12861.7 KOS19935.1 - 0.075 13.1 5.9 0.25 11.4 5.9 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Rootletin PF15035.6 KOS19935.1 - 0.14 12.1 8.5 0.25 11.3 8.5 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion PRKG1_interact PF15898.5 KOS19935.1 - 0.26 12.2 9.9 0.18 12.7 7.8 1.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 KOS19935.1 - 0.28 11.9 2.5 0.21 12.3 0.4 1.9 2 0 0 2 2 2 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 KOS19935.1 - 0.58 9.7 6.8 0.87 9.1 6.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit BLOC1_2 PF10046.9 KOS19935.1 - 0.64 10.4 4.3 4.7 7.6 0.6 2.3 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CENP-H PF05837.12 KOS19935.1 - 1.2 9.6 12.0 0.12 12.8 3.2 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DHR10 PF18595.1 KOS19935.1 - 1.4 9.0 12.0 2.5 8.2 10.9 2.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain GARP PF16731.5 KOS19935.1 - 2 8.1 11.4 66 3.1 11.4 2.3 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma zf-C3HC4_4 PF15227.6 KOS19935.1 - 2.2 8.5 8.9 4.5 7.5 6.9 2.6 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING XhlA PF10779.9 KOS19935.1 - 7.3 6.9 7.1 26 5.1 1.3 2.7 2 1 0 2 2 2 0 Haemolysin XhlA STE2 PF02116.15 KOS19936.1 - 3.7e-81 272.5 16.5 5.9e-81 271.8 16.5 1.3 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR PalH PF08733.10 KOS19936.1 - 0.0026 16.8 9.8 0.0039 16.2 9.8 1.2 1 0 0 1 1 1 1 PalH/RIM21 UEV PF05743.13 KOS19937.1 - 6.7e-37 126.0 0.0 1.1e-36 125.4 0.0 1.3 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 KOS19937.1 - 6.2e-21 74.1 0.0 1.6e-20 72.8 0.0 1.7 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 KOS19937.1 - 0.0037 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PhoLip_ATPase_C PF16212.5 KOS19938.1 - 2.4e-79 266.6 31.8 2.4e-79 266.6 31.8 2.4 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOS19938.1 - 4.6e-19 67.9 0.3 4.6e-19 67.9 0.3 2.0 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 KOS19938.1 - 2.5e-12 46.7 0.0 1.2e-11 44.6 0.0 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOS19938.1 - 1.3e-10 41.9 3.0 3.4e-07 30.8 1.0 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOS19938.1 - 0.00013 21.6 0.0 0.0046 16.5 0.0 2.8 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOS19938.1 - 0.018 14.8 0.4 0.034 13.9 0.4 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase PQ-loop PF04193.14 KOS19939.1 - 4.6e-36 122.4 17.7 1.7e-21 75.7 2.2 3.4 4 0 0 4 4 4 2 PQ loop repeat ER_lumen_recept PF00810.18 KOS19939.1 - 0.092 13.6 3.1 0.89 10.4 0.1 2.8 1 1 1 2 2 2 0 ER lumen protein retaining receptor S1-P1_nuclease PF02265.16 KOS19940.1 - 3.4e-67 226.9 4.7 3.9e-67 226.7 4.7 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease W_rich_C PF07483.11 KOS19940.1 - 0.032 14.4 0.1 0.059 13.5 0.1 1.5 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain zf-RING_2 PF13639.6 KOS19941.1 - 4e-12 46.2 5.3 6.1e-12 45.7 5.3 1.3 1 0 0 1 1 1 1 Ring finger domain PA PF02225.22 KOS19941.1 - 5e-10 39.3 0.0 1.3e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 PA domain zf-C3HC4_2 PF13923.6 KOS19941.1 - 3.5e-09 36.4 3.9 5.3e-09 35.8 3.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS19941.1 - 8.7e-09 35.5 2.1 1.6e-08 34.7 2.1 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 KOS19941.1 - 1.6e-08 34.3 3.2 2.4e-08 33.7 3.2 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS19941.1 - 1.3e-07 31.2 2.5 1.3e-07 31.2 2.5 1.8 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KOS19941.1 - 2e-06 27.7 1.6 5.4e-06 26.3 0.3 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS19941.1 - 2e-06 27.6 2.3 3e-06 27.1 2.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 KOS19941.1 - 4.2e-05 23.3 3.0 6.2e-05 22.8 3.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 KOS19941.1 - 0.0016 18.5 0.8 0.0028 17.6 0.8 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 KOS19941.1 - 0.015 15.2 2.7 0.026 14.4 2.7 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 KOS19941.1 - 0.03 13.9 2.1 0.058 13.0 2.1 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 KOS19941.1 - 0.19 11.9 2.7 0.6 10.3 2.8 1.8 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 KOS19941.1 - 0.2 11.9 2.8 0.61 10.3 2.8 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 KOS19941.1 - 0.28 11.3 3.0 0.53 10.5 2.8 1.6 1 1 0 1 1 1 0 RING-variant domain zf-RING-like PF08746.11 KOS19941.1 - 0.42 11.0 3.0 0.72 10.2 3.0 1.4 1 0 0 1 1 1 0 RING-like domain zf-RING_4 PF14570.6 KOS19941.1 - 1.3 8.8 3.4 2.5 8.0 3.4 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Semialdhyde_dhC PF02774.18 KOS19942.1 - 2.1e-36 125.7 0.0 2.8e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 KOS19942.1 - 1.2e-26 93.6 0.0 3.3e-26 92.1 0.0 1.7 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Ipi1_N PF12333.8 KOS19943.1 - 4.1e-25 88.3 0.6 1.1e-24 86.9 0.0 2.0 2 1 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation HEAT_2 PF13646.6 KOS19943.1 - 0.067 13.6 0.2 0.15 12.5 0.2 1.6 1 0 0 1 1 1 0 HEAT repeats UPF0139 PF03669.13 KOS19944.1 - 4.3e-06 26.5 0.0 5.4e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0139) Nucleoside_tran PF01733.18 KOS19944.1 - 0.027 13.9 0.1 0.031 13.7 0.1 1.1 1 0 0 1 1 1 0 Nucleoside transporter Mg_trans_NIPA PF05653.14 KOS19945.1 - 5.6e-13 48.7 9.6 8.9e-13 48.0 9.6 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOS19945.1 - 7.1e-05 23.0 16.4 0.00072 19.7 0.1 2.7 2 1 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 KOS19945.1 - 0.034 13.4 11.2 0.01 15.1 4.8 2.5 1 1 2 3 3 3 0 Purine nucleobase transmembrane transport DUF1077 PF06417.12 KOS19945.1 - 0.17 11.9 0.2 0.87 9.6 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1077) SMC_N PF02463.19 KOS19946.1 - 2e-22 79.8 0.0 3.8e-22 78.8 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOS19946.1 - 1.9e-11 44.8 60.5 5.5e-08 33.5 38.3 5.3 2 2 0 2 2 1 1 AAA domain AAA_15 PF13175.6 KOS19946.1 - 2.2e-08 34.3 17.9 3.9e-05 23.5 0.0 3.8 2 2 1 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 KOS19946.1 - 2.3e-08 34.2 2.2 0.0016 18.3 0.0 2.8 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system BLOC1_2 PF10046.9 KOS19946.1 - 8.1e-05 22.8 0.3 8.1e-05 22.8 0.3 7.2 6 2 0 7 7 6 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 AAA_29 PF13555.6 KOS19946.1 - 0.00057 19.6 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain CtIP_N PF10482.9 KOS19946.1 - 0.03 14.4 0.6 0.03 14.4 0.6 5.9 4 2 2 6 6 6 0 Tumour-suppressor protein CtIP N-terminal domain Baculo_PEP_C PF04513.12 KOS19946.1 - 0.035 14.2 15.1 1.1 9.4 0.0 5.1 5 0 0 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5051 PF16473.5 KOS19946.1 - 0.045 13.7 2.2 0.23 11.4 0.2 3.1 3 0 0 3 3 3 0 3' exoribonuclease, RNase T-like RsgA_GTPase PF03193.16 KOS19946.1 - 0.045 13.6 0.0 0.3 11.0 0.0 2.5 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 KOS19946.1 - 0.099 12.6 0.6 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 NACHT domain AAA_27 PF13514.6 KOS19946.1 - 0.46 10.1 0.0 0.46 10.1 0.0 4.9 5 1 1 6 6 6 0 AAA domain MFS_1 PF07690.16 KOS19947.1 - 6e-45 153.7 42.7 1.1e-44 152.9 42.7 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4407 PF14362.6 KOS19947.1 - 0.25 10.6 3.0 10 5.4 1.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF1772 PF08592.11 KOS19949.1 - 1.4e-32 112.9 7.7 1.4e-32 112.9 7.7 1.4 2 0 0 2 2 2 1 Domain of unknown function (DUF1772) EthD PF07110.11 KOS19950.1 - 8.3e-20 71.7 0.7 1e-19 71.4 0.7 1.1 1 0 0 1 1 1 1 EthD domain MmlI PF09448.10 KOS19950.1 - 0.0047 17.4 0.2 0.0069 16.8 0.2 1.3 1 1 0 1 1 1 1 Methylmuconolactone methyl-isomerase PsaA_PsaB PF00223.19 KOS19950.1 - 0.089 11.0 0.0 0.1 10.8 0.0 1.1 1 0 0 1 1 1 0 Photosystem I psaA/psaB protein ketoacyl-synt PF00109.26 KOS19951.1 - 6.3e-72 242.2 0.2 2e-71 240.5 0.0 2.0 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain SAT PF16073.5 KOS19951.1 - 2.7e-42 145.1 0.6 1.2e-40 139.8 0.1 2.5 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Acyl_transf_1 PF00698.21 KOS19951.1 - 1.4e-38 133.2 0.0 4.3e-38 131.6 0.0 1.7 2 0 0 2 2 2 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 KOS19951.1 - 1.1e-35 122.1 0.7 2.5e-35 121.0 0.7 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain PP-binding PF00550.25 KOS19951.1 - 4.4e-12 46.2 0.4 1.4e-11 44.6 0.4 1.9 1 0 0 1 1 1 1 Phosphopantetheine attachment site KAsynt_C_assoc PF16197.5 KOS19951.1 - 6.6e-10 39.4 0.0 2.5e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension PS-DH PF14765.6 KOS19951.1 - 4.2e-06 26.2 0.0 7.7e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Thiolase_N PF00108.23 KOS19951.1 - 2.1e-05 24.1 0.2 4.9e-05 22.8 0.2 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain Lactamase_B PF00753.27 KOS19952.1 - 5.5e-16 59.2 3.9 3.1e-14 53.4 3.9 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOS19952.1 - 0.00012 21.6 0.3 0.00021 20.8 0.3 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain BLACT_WH PF17778.1 KOS19952.1 - 0.019 14.9 0.0 0.049 13.6 0.0 1.8 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain DUF4164 PF13747.6 KOS19952.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) FAD_binding_3 PF01494.19 KOS19953.1 - 9e-27 94.2 0.0 2.1e-26 93.0 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 KOS19953.1 - 1.1e-05 24.9 0.7 0.032 13.4 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS19953.1 - 3.6e-05 23.2 1.1 0.097 11.9 0.9 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOS19953.1 - 0.0002 20.5 0.7 0.4 9.7 0.0 2.2 2 0 0 2 2 2 2 Lycopene cyclase protein Amino_oxidase PF01593.24 KOS19953.1 - 0.00034 20.0 0.2 0.0012 18.3 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase DAO PF01266.24 KOS19953.1 - 0.00088 18.9 2.2 0.33 10.5 1.6 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 KOS19953.1 - 0.0046 15.9 2.7 0.15 10.9 0.1 2.2 1 1 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 KOS19953.1 - 0.012 15.8 0.3 0.025 14.8 0.3 1.5 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOS19953.1 - 0.037 14.6 1.0 2.4 8.8 0.4 3.3 3 1 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 KOS19953.1 - 0.042 12.9 0.0 0.31 10.1 0.0 2.1 2 0 0 2 2 2 0 Squalene epoxidase DUF1420 PF07220.11 KOS19953.1 - 0.14 10.7 0.1 0.76 8.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1420) GIDA PF01134.22 KOS19953.1 - 0.22 10.6 0.0 0.48 9.4 0.0 1.5 1 1 0 1 1 1 0 Glucose inhibited division protein A Pinin_SDK_memA PF04696.13 KOS19954.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region polyprenyl_synt PF00348.17 KOS19955.1 - 4.7e-24 84.8 0.0 6.6e-24 84.3 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Glyco_hydro_12 PF01670.16 KOS19957.1 - 6.3e-58 196.3 5.2 7.4e-58 196.0 5.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 12 Sugar_tr PF00083.24 KOS19958.1 - 5e-116 388.2 30.5 5.8e-116 388.0 30.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS19958.1 - 1.3e-22 80.3 59.4 1.2e-19 70.4 28.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 KOS19959.1 - 1.8e-52 178.4 0.0 2.3e-52 178.0 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family AP_endonuc_2 PF01261.24 KOS19959.1 - 0.059 12.8 0.1 0.12 11.8 0.1 1.6 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel DUF3297 PF11730.8 KOS19959.1 - 0.16 11.9 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3297) GCIP PF13324.6 KOS19960.1 - 2.6e-19 69.9 0.0 9.8e-19 68.0 0.0 1.8 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting Serglycin PF04360.12 KOS19960.1 - 0.29 11.1 2.6 0.63 10.0 2.6 1.5 1 0 0 1 1 1 0 Serglycin PRKCSH-like PF12999.7 KOS19961.1 - 1.1e-42 145.8 2.1 2.6e-23 82.7 0.1 2.9 3 0 0 3 3 3 2 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 KOS19961.1 - 5.9e-30 104.0 0.9 5.9e-30 104.0 0.9 1.6 2 0 0 2 2 2 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 KOS19961.1 - 3.9e-11 43.8 0.4 9.3e-11 42.6 0.4 1.7 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein ADIP PF11559.8 KOS19961.1 - 0.00049 20.2 8.2 1 9.5 0.0 3.3 3 0 0 3 3 3 2 Afadin- and alpha -actinin-Binding ATG27 PF09451.10 KOS19961.1 - 0.0058 16.5 0.6 0.0058 16.5 0.6 1.7 2 0 0 2 2 2 1 Autophagy-related protein 27 Prefoldin_2 PF01920.20 KOS19961.1 - 0.075 13.0 11.6 0.21 11.6 2.0 3.4 3 0 0 3 3 3 0 Prefoldin subunit Fzo_mitofusin PF04799.13 KOS19961.1 - 0.11 12.1 6.6 6.3 6.3 0.1 3.2 3 0 0 3 3 3 0 fzo-like conserved region Phage_GP20 PF06810.11 KOS19961.1 - 0.34 10.7 8.4 0.49 10.2 0.6 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 Filament PF00038.21 KOS19961.1 - 0.38 10.3 14.9 0.92 9.0 4.5 2.8 3 0 0 3 3 3 0 Intermediate filament protein DivIC PF04977.15 KOS19961.1 - 0.41 10.5 9.4 0.33 10.7 1.2 3.0 3 0 0 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 KOS19961.1 - 0.44 9.8 8.2 0.29 10.5 4.7 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) CP12 PF02672.15 KOS19961.1 - 0.5 11.2 3.7 0.39 11.5 0.3 2.5 2 0 0 2 2 2 0 CP12 domain Ldl_recept_a PF00057.18 KOS19961.1 - 0.71 10.1 11.8 0.22 11.8 3.0 2.6 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A OmpH PF03938.14 KOS19961.1 - 1.7 9.0 7.4 65 3.9 5.9 2.8 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) Jnk-SapK_ap_N PF09744.9 KOS19961.1 - 2.5 8.3 12.0 3 8.1 3.9 3.1 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 GTP-bdg_M PF16360.5 KOS19961.1 - 4.6 7.9 10.6 0.58 10.8 1.0 3.2 2 1 1 3 3 3 0 GTP-binding GTPase Middle Region SOGA PF11365.8 KOS19961.1 - 5.1 8.3 10.2 0.98 10.6 0.4 2.8 3 0 0 3 3 2 0 Protein SOGA CdvA PF18822.1 KOS19961.1 - 6.8 6.5 10.0 3.5 7.5 2.9 2.8 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Prefoldin PF02996.17 KOS19961.1 - 7.9 6.4 8.1 19 5.2 0.5 3.1 3 0 0 3 3 3 0 Prefoldin subunit MerR-DNA-bind PF09278.11 KOS19961.1 - 9.1 6.9 10.1 2 9.0 1.7 3.1 3 0 0 3 3 3 0 MerR, DNA binding Methyltransf_12 PF08242.12 KOS19962.1 - 3.3e-07 31.0 0.0 1.2e-06 29.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS19962.1 - 1.8e-06 28.5 0.0 4.2e-05 24.1 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19962.1 - 1.9e-06 28.5 0.0 0.0053 17.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOS19962.1 - 8.2e-06 25.8 0.0 1e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Serglycin PF04360.12 KOS19962.1 - 0.025 14.5 2.7 0.052 13.5 2.7 1.5 1 0 0 1 1 1 0 Serglycin FAT PF02259.23 KOS19963.1 - 4.8e-132 440.4 5.7 4.8e-132 440.4 5.7 1.8 2 0 0 2 2 2 1 FAT domain DUF3385 PF11865.8 KOS19963.1 - 1.4e-76 255.9 6.9 6.4e-74 247.2 0.5 5.2 5 1 0 5 5 5 1 Domain of unknown function (DUF3385) PI3_PI4_kinase PF00454.27 KOS19963.1 - 1.3e-74 251.1 0.1 2.5e-74 250.3 0.1 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 KOS19963.1 - 3.9e-45 152.3 0.2 3.9e-45 152.3 0.2 3.9 5 0 0 5 5 4 1 FKBP12-rapamycin binding domain HEAT PF02985.22 KOS19963.1 - 2.4e-17 61.5 17.4 0.0008 19.5 0.0 12.8 14 0 0 14 14 14 3 HEAT repeat HEAT_2 PF13646.6 KOS19963.1 - 2.7e-15 56.5 9.4 0.00014 22.2 0.0 9.2 8 2 2 10 10 10 2 HEAT repeats FATC PF02260.20 KOS19963.1 - 5.6e-13 48.5 0.1 1.9e-12 46.8 0.1 2.0 1 0 0 1 1 1 1 FATC domain HEAT_EZ PF13513.6 KOS19963.1 - 5.5e-12 45.9 10.6 0.0014 19.1 0.0 11.0 12 1 1 13 13 11 2 HEAT-like repeat Cnd1 PF12717.7 KOS19963.1 - 2.3e-10 40.7 2.7 0.02 15.0 0.1 6.9 4 2 2 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 KOS19963.1 - 3e-08 34.2 0.1 16 6.2 0.0 7.6 6 1 1 7 7 7 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 KOS19963.1 - 3.2e-07 30.2 3.2 9.1 5.8 0.0 6.4 6 1 1 7 7 7 2 CLASP N terminal Adaptin_N PF01602.20 KOS19963.1 - 2.3e-05 23.2 6.3 1.5 7.3 0.1 5.8 3 3 1 5 5 5 3 Adaptin N terminal region Baculo_PEP_C PF04513.12 KOS19963.1 - 0.0059 16.7 1.0 0.17 11.9 0.1 3.2 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus ANAPC3 PF12895.7 KOS19963.1 - 0.29 11.4 5.0 10 6.4 0.0 4.1 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Dopey_N PF04118.14 KOS19963.1 - 0.69 9.0 3.4 2.7 7.0 0.8 3.1 3 1 1 4 4 4 0 Dopey, N-terminal TPR_1 PF00515.28 KOS19963.1 - 0.89 9.5 3.3 87 3.2 0.1 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS19963.1 - 2.8 8.3 8.9 55 4.2 0.3 5.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Actin PF00022.19 KOS19964.1 - 3.4e-95 319.1 0.0 3.8e-94 315.6 0.0 1.9 1 1 0 1 1 1 1 Actin F-box-like PF12937.7 KOS19965.1 - 0.00034 20.4 1.6 0.0058 16.5 0.1 2.6 2 0 0 2 2 2 2 F-box-like ZZ PF00569.17 KOS19966.1 - 0.18 11.6 2.8 0.29 11.0 2.8 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type Tetraspanin PF00335.20 KOS19967.1 - 3.5e-07 30.2 3.0 5.3e-07 29.6 3.0 1.2 1 0 0 1 1 1 1 Tetraspanin family Ctr PF04145.15 KOS19968.1 - 4.8e-29 101.9 0.0 5.8e-29 101.6 0.0 1.1 1 0 0 1 1 1 1 Ctr copper transporter family SRF-TF PF00319.18 KOS19969.1 - 4.6e-21 74.0 0.1 6.4e-21 73.6 0.1 1.2 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Pkinase PF00069.25 KOS19970.1 - 3.4e-56 190.5 0.0 4.2e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS19970.1 - 5.2e-32 111.1 0.0 6.8e-32 110.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS19970.1 - 3e-08 33.3 0.0 3.8e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOS19970.1 - 0.00037 19.5 0.2 0.00057 18.9 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS19970.1 - 0.00049 19.5 0.1 0.0008 18.8 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS19970.1 - 0.015 15.2 0.1 0.045 13.7 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 KOS19970.1 - 0.023 14.3 0.1 0.036 13.7 0.1 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Prenyltransf PF01255.19 KOS19971.1 - 0.095 12.2 0.0 0.19 11.2 0.0 1.4 1 0 0 1 1 1 0 Putative undecaprenyl diphosphate synthase RRM_1 PF00076.22 KOS19972.1 - 1.6e-79 261.7 5.0 1.2e-18 66.6 0.2 5.4 5 0 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 KOS19972.1 - 2e-26 91.9 2.3 7.5e-26 90.1 2.3 2.0 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain RRM_5 PF13893.6 KOS19972.1 - 5.4e-09 35.7 0.0 0.03 13.9 0.0 5.1 3 2 2 5 5 5 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS19972.1 - 9.6e-07 28.6 0.1 0.0035 17.2 0.0 4.0 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 KOS19972.1 - 2.5e-05 24.3 0.8 0.91 9.7 0.0 5.2 4 1 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOS19972.1 - 0.0024 17.8 2.7 9.7 6.3 0.1 4.6 4 1 0 4 4 4 2 Nup53/35/40-type RNA recognition motif CbiG_mid PF11761.8 KOS19972.1 - 0.0057 16.8 0.7 11 6.2 0.0 3.8 3 1 0 4 4 3 1 Cobalamin biosynthesis central region PHM7_cyt PF14703.6 KOS19972.1 - 0.06 13.6 7.2 38 4.4 0.0 4.9 2 1 1 4 4 4 0 Cytosolic domain of 10TM putative phosphate transporter OB_RNB PF08206.11 KOS19972.1 - 0.069 12.8 2.6 9.2 6.0 0.0 3.5 3 0 0 3 3 3 0 Ribonuclease B OB domain YflT PF11181.8 KOS19972.1 - 0.16 12.5 6.6 1 9.9 0.6 3.4 3 0 0 3 3 3 0 Heat induced stress protein YflT DHHA1 PF02272.19 KOS19972.1 - 0.36 11.2 7.9 0.78 10.2 0.2 3.5 3 0 0 3 3 3 0 DHHA1 domain FAM176 PF14851.6 KOS19972.1 - 3.4 7.3 6.8 9 6.0 6.8 1.6 1 0 0 1 1 1 0 FAM176 family SOBP PF15279.6 KOS19972.1 - 5.2 7.6 14.6 1.1 9.9 10.7 1.7 1 1 0 1 1 1 0 Sine oculis-binding protein Eapp_C PF10238.9 KOS19972.1 - 7.1 6.7 7.2 23 5.1 6.7 1.9 1 1 0 1 1 1 0 E2F-associated phosphoprotein CDC45 PF02724.14 KOS19972.1 - 7.6 4.7 11.8 12 4.0 11.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOS19972.1 - 8.9 4.9 5.2 13 4.4 5.2 1.2 1 0 0 1 1 1 0 Presenilin TBP PF00352.21 KOS19973.1 - 1.8e-52 175.2 0.1 3.5e-32 110.2 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 KOS19973.1 - 0.00011 22.3 0.0 0.3 11.2 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) DAO PF01266.24 KOS19974.1 - 6.7e-23 81.8 11.1 1.4e-22 80.8 11.1 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS19974.1 - 0.00071 19.7 0.0 0.0024 18.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOS19974.1 - 0.047 13.7 2.5 0.5 10.3 0.0 2.9 2 1 1 3 3 3 0 FAD-NAD(P)-binding GMC_oxred_N PF00732.19 KOS19974.1 - 0.051 12.9 0.4 0.13 11.6 0.1 1.8 3 0 0 3 3 3 0 GMC oxidoreductase Glu_dehyd_C PF16912.5 KOS19974.1 - 0.18 11.3 0.5 7.5 6.0 0.0 2.8 3 0 0 3 3 3 0 Glucose dehydrogenase C-terminus HECT PF00632.25 KOS19975.1 - 4.5e-79 266.1 0.0 5.8e-79 265.7 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) OmdA PF13376.6 KOS19975.1 - 0.17 11.9 3.0 8.1 6.5 2.6 2.5 2 0 0 2 2 2 0 Bacteriocin-protection, YdeI or OmpD-Associated ETF_QO PF05187.13 KOS19976.1 - 2.3e-47 159.4 0.6 3.6e-47 158.8 0.6 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S NAD_binding_8 PF13450.6 KOS19976.1 - 5.3e-08 33.0 0.0 1.2e-07 31.8 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS19976.1 - 1e-07 31.9 2.1 0.0001 22.0 0.6 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS19976.1 - 5.2e-05 22.5 1.8 0.01 14.9 1.5 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 KOS19976.1 - 5.3e-05 22.6 0.0 0.00016 21.0 0.0 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS19976.1 - 5.7e-05 22.5 0.0 0.0015 17.8 0.0 2.1 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 KOS19976.1 - 0.00057 19.3 0.0 0.00085 18.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS19976.1 - 0.00063 18.5 0.5 0.00095 18.0 0.5 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 KOS19976.1 - 0.00084 18.7 0.2 0.0013 18.1 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 KOS19976.1 - 0.0014 18.7 0.3 0.0063 16.5 0.1 1.9 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 KOS19976.1 - 0.0019 18.7 0.2 2 9.1 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS19976.1 - 0.0057 15.5 0.1 0.43 9.4 0.1 2.2 1 1 1 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.6 KOS19976.1 - 0.0064 15.8 0.2 0.0092 15.3 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.7 KOS19976.1 - 0.013 16.1 1.1 0.029 15.0 1.1 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Lycopene_cycl PF05834.12 KOS19976.1 - 0.059 12.4 0.5 0.082 11.9 0.5 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 KOS19976.1 - 0.086 12.1 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4_2 PF12797.7 KOS19976.1 - 0.16 12.1 0.7 0.43 10.8 0.7 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain GIDA PF01134.22 KOS19976.1 - 0.23 10.5 0.5 0.34 10.0 0.5 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Methyltransf_16 PF10294.9 KOS19978.1 - 1.6e-13 50.7 0.0 4.7e-10 39.5 0.0 2.1 1 1 1 2 2 2 2 Lysine methyltransferase PrmA PF06325.13 KOS19978.1 - 0.016 14.6 0.0 0.023 14.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Surp PF01805.20 KOS19979.1 - 1.5e-09 37.7 0.0 3.4e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 Surp module Copper-fist PF00649.18 KOS19980.1 - 2.8e-18 65.1 2.8 2.9e-18 65.1 0.9 2.1 2 0 0 2 2 2 1 Copper fist DNA binding domain Metallothio_2 PF01439.18 KOS19980.1 - 0.016 16.0 3.9 0.016 16.0 3.9 2.2 3 0 0 3 3 3 0 Metallothionein Metallothio_PEC PF02068.16 KOS19980.1 - 9.7 6.6 23.3 0.17 12.3 3.8 2.9 2 1 0 2 2 2 0 Plant PEC family metallothionein BPL_N PF09825.9 KOS19981.1 - 6.1e-132 440.3 0.0 7.8e-132 439.9 0.0 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 KOS19981.1 - 7.4e-22 77.7 0.0 1.1e-21 77.0 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Mgm101p PF06420.12 KOS19982.1 - 1.3e-81 272.1 0.0 1.6e-81 271.8 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 Pex14_N PF04695.13 KOS19982.1 - 8.8 7.0 10.0 11 6.7 8.4 2.0 2 1 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TB2_DP1_HVA22 PF03134.19 KOS19983.1 - 1.1e-25 89.4 8.9 1.7e-25 88.7 8.9 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Serglycin PF04360.12 KOS19984.1 - 7.9 6.4 24.3 4.1 7.3 16.2 2.5 1 1 0 2 2 2 0 Serglycin Sulfotransfer_4 PF17784.1 KOS19985.1 - 4.2e-10 39.8 0.0 4.8e-10 39.6 0.0 1.0 1 0 0 1 1 1 1 Sulfotransferase domain WSC PF01822.19 KOS19986.1 - 3.8e-06 27.0 6.0 1.9e-05 24.7 6.0 2.3 1 1 0 1 1 1 1 WSC domain DUF2865 PF11064.8 KOS19986.1 - 0.016 15.6 1.1 0.016 15.6 1.1 2.1 2 1 0 2 2 1 0 Protein of unknown function (DUF2865) RR_TM4-6 PF06459.12 KOS19986.1 - 0.021 14.7 13.6 0.029 14.2 13.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Roughex PF06020.11 KOS19986.1 - 0.027 13.6 18.2 0.043 12.9 18.2 1.3 1 0 0 1 1 1 0 Drosophila roughex protein EIIBC-GUT_N PF03612.14 KOS19986.1 - 0.029 14.1 7.3 0.059 13.1 7.3 1.5 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus BAF1_ABF1 PF04684.13 KOS19986.1 - 0.033 13.3 7.4 0.038 13.1 7.4 1.3 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ALMT PF11744.8 KOS19986.1 - 0.24 10.2 5.9 0.31 9.8 5.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Vfa1 PF08432.10 KOS19986.1 - 0.34 11.2 11.0 0.54 10.6 11.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S64 PF08192.11 KOS19986.1 - 0.37 9.2 9.1 0.48 8.9 9.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4045 PF13254.6 KOS19986.1 - 0.5 9.9 13.0 0.66 9.6 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Raftlin PF15250.6 KOS19986.1 - 0.63 8.7 11.9 0.91 8.2 11.9 1.2 1 0 0 1 1 1 0 Raftlin Nop14 PF04147.12 KOS19986.1 - 0.69 8.1 17.1 0.89 7.7 17.1 1.1 1 0 0 1 1 1 0 Nop14-like family CPSF100_C PF13299.6 KOS19986.1 - 0.89 9.7 9.2 1.8 8.7 9.2 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 KOS19986.1 - 0.92 9.6 5.4 1.3 9.1 5.4 1.4 1 0 0 1 1 1 0 DDHD domain CCSAP PF15748.5 KOS19986.1 - 1.2 9.2 17.0 1.8 8.7 17.0 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Asp-B-Hydro_N PF05279.11 KOS19986.1 - 1.5 8.8 19.0 2.2 8.3 19.0 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF4746 PF15928.5 KOS19986.1 - 1.7 8.0 15.8 2.4 7.5 15.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 KOS19986.1 - 2 8.4 5.5 2.9 7.8 5.5 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Lin-8 PF03353.15 KOS19986.1 - 2 7.9 13.8 2.9 7.4 13.8 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2052 PF09747.9 KOS19986.1 - 2.1 8.4 21.5 3.3 7.8 21.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 KOS19986.1 - 3.7 5.7 14.3 4.8 5.4 14.3 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 KOS19986.1 - 4.5 6.9 12.2 8.1 6.1 12.2 1.4 1 0 0 1 1 1 0 FAM176 family DUF4637 PF15470.6 KOS19986.1 - 4.5 7.0 16.1 1.7 8.4 13.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Spore_III_AF PF09581.10 KOS19986.1 - 5.5 7.0 12.6 8.9 6.3 12.6 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF2151 PF10221.9 KOS19986.1 - 6.2 5.3 8.0 8.5 4.8 8.0 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Pox_Ag35 PF03286.14 KOS19986.1 - 6.7 6.5 14.4 11 5.8 14.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MCM_bind PF09739.9 KOS19986.1 - 7 5.0 9.7 10 4.4 9.7 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor BORG_CEP PF14957.6 KOS19986.1 - 9.4 7.4 7.5 18 6.5 7.5 1.6 1 0 0 1 1 1 0 Cdc42 effector Methyltransf_23 PF13489.6 KOS19987.1 - 1.6e-21 76.9 0.0 2.4e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS19987.1 - 1.1e-12 48.4 0.0 2.8e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS19987.1 - 3e-12 47.0 0.0 6.1e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS19987.1 - 4e-11 42.9 0.0 7.2e-10 38.9 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS19987.1 - 7.9e-11 42.6 0.0 6.2e-10 39.7 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOS19987.1 - 0.00013 21.5 0.0 0.00064 19.2 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase FtsJ PF01728.19 KOS19987.1 - 0.0026 17.9 0.0 0.0045 17.1 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ubie_methyltran PF01209.18 KOS19987.1 - 0.0029 17.0 0.0 0.012 14.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_17 PF12692.7 KOS19987.1 - 0.003 17.6 0.0 0.011 15.8 0.0 1.8 2 0 0 2 2 2 1 S-adenosyl-L-methionine methyltransferase CheR PF01739.18 KOS19987.1 - 0.021 14.3 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MetW PF07021.12 KOS19987.1 - 0.028 14.0 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW MTS PF05175.14 KOS19987.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.20 KOS19987.1 - 0.15 11.3 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Arm PF00514.23 KOS19989.1 - 0.028 14.5 6.7 0.21 11.7 0.4 3.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 KOS19989.1 - 0.047 14.1 5.5 0.77 10.2 0.1 3.8 3 1 0 3 3 3 0 HEAT repeats RICTOR_V PF14668.6 KOS19989.1 - 0.15 12.3 0.0 2.8 8.2 0.0 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 Pam16 PF03656.13 KOS19990.1 - 4.3e-29 101.1 0.2 5.4e-29 100.8 0.2 1.1 1 0 0 1 1 1 1 Pam16 UFD1 PF03152.14 KOS19991.1 - 4.2e-25 88.2 0.0 6e-13 48.6 0.0 2.6 2 1 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 KOS19991.1 - 1e-07 32.1 0.2 3.1e-07 30.5 0.2 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zf-C2H2 PF00096.26 KOS19991.1 - 6 7.5 16.5 1.6 9.3 0.6 3.9 3 0 0 3 3 3 0 Zinc finger, C2H2 type GFA PF04828.14 KOS19993.1 - 9.7e-05 22.6 0.6 0.00015 22.0 0.6 1.3 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme Methyltransf_16 PF10294.9 KOS19996.1 - 2.2e-22 79.6 0.0 5.1e-22 78.4 0.0 1.6 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOS19996.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_23 PF13489.6 KOS19996.1 - 0.02 14.7 0.0 0.031 14.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain ABC2_membrane PF01061.24 KOS19997.1 - 1.3e-73 246.9 55.3 9.7e-38 129.7 21.9 2.6 3 0 0 3 3 3 2 ABC-2 type transporter ABC_tran PF00005.27 KOS19997.1 - 9.6e-36 123.3 0.0 4.3e-17 62.9 0.0 2.4 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 KOS19997.1 - 7.2e-23 80.3 1.7 1.2e-22 79.6 0.0 2.4 2 0 0 2 2 1 1 CDR ABC transporter ABC_trans_N PF14510.6 KOS19997.1 - 2.7e-11 43.9 0.1 6.9e-11 42.6 0.1 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal ABC2_membrane_3 PF12698.7 KOS19997.1 - 1e-07 31.4 35.8 9.5e-07 28.2 10.9 2.6 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 KOS19997.1 - 1.5e-06 28.2 0.0 0.073 12.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 KOS19997.1 - 1.8e-06 28.4 0.0 0.0057 17.1 0.0 2.9 3 0 0 3 3 2 2 AAA ATPase domain AAA_33 PF13671.6 KOS19997.1 - 3.2e-06 27.4 0.0 0.0032 17.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.6 KOS19997.1 - 9.5e-06 26.1 0.0 0.18 12.3 0.0 2.7 3 0 0 3 3 2 2 AAA domain AAA_18 PF13238.6 KOS19997.1 - 5.4e-05 23.8 0.0 0.024 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOS19997.1 - 0.0001 21.9 0.1 0.008 15.9 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_25 PF13481.6 KOS19997.1 - 0.00046 19.8 0.2 0.0066 16.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 KOS19997.1 - 0.00048 20.1 0.0 0.009 15.9 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase SMC_N PF02463.19 KOS19997.1 - 0.0019 17.7 0.0 0.11 11.9 0.0 3.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 KOS19997.1 - 0.0022 18.2 0.0 0.086 13.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 KOS19997.1 - 0.0031 17.8 0.0 0.75 10.1 0.0 2.7 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 KOS19997.1 - 0.0047 16.5 0.6 0.39 10.3 0.2 2.3 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 KOS19997.1 - 0.0076 16.2 0.3 6.1 6.7 0.1 2.6 2 0 0 2 2 2 2 NACHT domain DnaB_C PF03796.15 KOS19997.1 - 0.018 14.4 0.0 0.41 9.9 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_30 PF13604.6 KOS19997.1 - 0.028 14.1 0.5 2.7 7.6 0.2 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 KOS19997.1 - 0.065 13.7 0.1 16 5.9 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOS19997.1 - 0.12 12.1 0.0 9.6 5.9 0.0 2.8 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 KOS19997.1 - 0.18 11.5 0.2 10 5.8 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 KOS19997.1 - 0.38 11.2 0.0 0.38 11.2 0.0 2.5 3 0 0 3 3 2 0 AAA domain Fungal_trans PF04082.18 KOS19999.1 - 2.8e-11 43.0 0.2 5.1e-11 42.1 0.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain Oxidored-like PF09791.9 KOS20000.1 - 4.6e-25 87.0 3.7 7e-25 86.4 3.7 1.3 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Pribosyltran PF00156.27 KOS20001.1 - 7e-08 32.1 0.0 1.1e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain DPM3 PF08285.11 KOS20002.1 - 1.2e-33 115.2 0.1 1.3e-33 115.1 0.1 1.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) p450 PF00067.22 KOS20005.1 - 4.4e-54 184.0 0.0 5.5e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 DUF3948 PF13134.6 KOS20005.1 - 0.12 12.1 0.0 0.12 12.1 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3948) Glyco_hydro_1 PF00232.18 KOS20006.1 - 7.2e-139 463.1 0.0 8.1e-139 462.9 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 1 Glyco_hydro_cc PF11790.8 KOS20006.1 - 0.00082 19.0 0.0 0.0019 17.8 0.0 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase catalytic core DUF3390 PF11870.8 KOS20007.1 - 0.11 12.9 0.6 0.33 11.4 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3390) TFB6 PF17110.5 KOS20008.1 - 7.7e-62 208.0 0.0 1.1e-61 207.5 0.0 1.2 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH DNA_pol_phi PF04931.13 KOS20008.1 - 0.14 10.3 15.7 0.19 9.8 15.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 KOS20008.1 - 0.22 10.9 5.0 0.3 10.5 5.0 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS20008.1 - 0.45 8.8 5.0 0.57 8.4 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Pes-10 PF07149.11 KOS20008.1 - 0.9 8.5 6.7 1.2 8.1 6.7 1.1 1 0 0 1 1 1 0 Pes-10 COPI_C PF06957.11 KOS20008.1 - 1.2 7.8 10.2 1.8 7.3 10.2 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus NOA36 PF06524.12 KOS20008.1 - 1.9 7.7 8.6 2.7 7.2 8.6 1.1 1 0 0 1 1 1 0 NOA36 protein LAT PF15234.6 KOS20008.1 - 3.8 7.2 5.0 5.9 6.6 1.0 2.1 2 0 0 2 2 2 0 Linker for activation of T-cells RRN3 PF05327.11 KOS20008.1 - 6.5 5.2 6.5 12 4.3 6.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAPP PF04051.16 KOS20010.1 - 1.6e-35 122.0 0.0 1.9e-35 121.7 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component PNGaseA PF12222.8 KOS20010.1 - 0.002 17.1 0.0 0.0024 16.8 0.0 1.1 1 0 0 1 1 1 1 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A WD40 PF00400.32 KOS20011.1 - 2.7e-40 135.6 2.7 1.7e-07 31.8 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20011.1 - 7.9e-14 51.7 0.1 0.00031 21.0 0.0 4.0 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS20011.1 - 0.00027 20.0 0.0 0.68 8.8 0.0 2.8 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOS20011.1 - 0.011 15.6 2.2 0.58 10.2 0.9 3.6 2 1 0 2 2 2 0 WD40-like Beta Propeller Repeat SGL PF08450.12 KOS20011.1 - 0.026 14.1 0.6 0.57 9.7 0.1 2.7 1 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Glyco_hydro_18 PF00704.28 KOS20012.1 - 5.6e-23 82.2 0.6 3.9e-22 79.4 0.6 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 DUF1993 PF09351.10 KOS20013.1 - 1.5e-22 80.5 0.0 1.7e-22 80.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) Fungal_trans_2 PF11951.8 KOS20014.1 - 9.6e-05 21.3 2.0 0.00012 21.0 1.1 1.6 1 1 1 2 2 2 1 Fungal specific transcription factor domain RTA1 PF04479.13 KOS20015.1 - 5.4e-65 218.9 10.1 6.4e-65 218.6 10.1 1.0 1 0 0 1 1 1 1 RTA1 like protein adh_short PF00106.25 KOS20016.1 - 1.8e-36 125.4 0.0 2.3e-36 125.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20016.1 - 2.7e-19 69.6 0.0 3.6e-19 69.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20016.1 - 3.7e-06 27.0 0.0 5.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS20016.1 - 0.00012 21.7 0.0 0.00016 21.2 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family F420_oxidored PF03807.17 KOS20016.1 - 0.0005 20.6 0.1 0.001 19.6 0.1 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Polysacc_synt_2 PF02719.15 KOS20016.1 - 0.0031 16.7 0.1 0.0046 16.1 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Shikimate_DH PF01488.20 KOS20016.1 - 0.019 15.0 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 KOS20016.1 - 0.022 14.2 0.2 0.069 12.5 0.1 1.7 1 1 1 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 KOS20016.1 - 0.077 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain 3Beta_HSD PF01073.19 KOS20016.1 - 0.12 11.4 0.1 0.17 10.9 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Phosphoesterase PF04185.14 KOS20017.1 - 3.4e-63 214.0 0.7 4.6e-63 213.6 0.7 1.2 1 0 0 1 1 1 1 Phosphoesterase family Dynamin_N PF00350.23 KOS20018.1 - 6.3e-22 78.4 0.4 1.8e-15 57.4 0.0 2.5 1 1 1 2 2 2 2 Dynamin family Dynamin_M PF01031.20 KOS20018.1 - 1.4e-20 73.7 0.0 1.7e-18 66.8 0.0 2.4 1 1 0 1 1 1 1 Dynamin central region MMR_HSR1 PF01926.23 KOS20018.1 - 7.2e-06 26.1 0.0 2.7e-05 24.2 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 KOS20018.1 - 0.0046 16.7 0.0 0.0079 16.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain DUF2267 PF10025.9 KOS20018.1 - 0.0048 17.2 0.5 1.3 9.3 0.1 2.8 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2267) GED PF02212.18 KOS20018.1 - 0.034 14.3 0.6 0.098 12.8 0.6 1.7 1 0 0 1 1 1 0 Dynamin GTPase effector domain Roc PF08477.13 KOS20018.1 - 0.045 14.0 0.0 2 8.7 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 KOS20018.1 - 0.051 13.1 0.0 2.5 7.6 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ABC_tran PF00005.27 KOS20018.1 - 0.06 13.9 0.2 0.25 11.9 0.0 2.1 2 1 0 2 2 2 0 ABC transporter DUF3932 PF13068.6 KOS20018.1 - 0.064 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3932) AAA_23 PF13476.6 KOS20018.1 - 0.21 12.1 0.7 1 9.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 KOS20018.1 - 0.7 10.3 0.0 0.7 10.3 0.0 2.9 4 0 0 4 4 4 0 AAA ATPase domain SLAC1 PF03595.17 KOS20019.1 - 2.3e-50 171.7 43.5 2.6e-50 171.6 43.5 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel AgrB PF04647.15 KOS20019.1 - 0.12 11.7 8.9 0.11 11.8 1.1 2.5 2 0 0 2 2 2 0 Accessory gene regulator B DUF5510 PF17629.2 KOS20019.1 - 0.16 11.9 0.3 0.16 11.9 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5510) MFS_1 PF07690.16 KOS20020.1 - 4.4e-25 88.4 41.3 1.7e-18 66.7 17.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily RGS PF00615.19 KOS20021.1 - 0.00014 22.1 0.0 0.00023 21.4 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Na_H_Exchanger PF00999.21 KOS20022.1 - 5.7e-36 124.1 26.0 5.7e-36 124.1 26.0 2.0 1 1 1 2 2 2 2 Sodium/hydrogen exchanger family Peptidase_M14 PF00246.24 KOS20023.1 - 3e-74 250.4 0.0 4.8e-74 249.8 0.0 1.3 2 0 0 2 2 2 1 Zinc carboxypeptidase Propep_M14 PF02244.16 KOS20023.1 - 2e-05 24.9 0.0 0.00011 22.5 0.0 2.3 3 0 0 3 3 3 1 Carboxypeptidase activation peptide Glyco_transf_54 PF04666.13 KOS20024.1 - 6e-09 35.2 0.0 3.7e-08 32.6 0.0 1.9 1 1 0 1 1 1 1 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region DUF3446 PF11928.8 KOS20024.1 - 0.017 15.4 6.9 0.017 15.4 6.9 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain DUF4630 PF15443.6 KOS20024.1 - 0.081 13.1 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4630) SCAMP PF04144.13 KOS20024.1 - 4.6 7.5 5.5 3.6 7.9 0.1 2.3 2 0 0 2 2 2 0 SCAMP family Cation_ATPase_C PF00689.21 KOS20025.1 - 4.3e-42 143.9 5.7 4.3e-42 143.9 5.7 3.0 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOS20025.1 - 5.7e-26 91.1 7.6 2.4e-24 85.8 3.5 3.5 2 1 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 KOS20025.1 - 2.3e-20 73.8 0.5 4e-09 37.1 0.1 3.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS20025.1 - 6.7e-17 61.4 0.0 1.3e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOS20025.1 - 2.9e-13 49.3 0.0 7.6e-13 47.9 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus HAD PF12710.7 KOS20025.1 - 0.00031 21.2 0.0 0.029 14.8 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOS20025.1 - 0.00036 20.3 0.1 0.00068 19.5 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase GHMP_kinases_N PF00288.26 KOS20025.1 - 8.5 6.7 7.1 13 6.1 0.6 3.2 2 0 0 2 2 2 0 GHMP kinases N terminal domain HORMA PF02301.18 KOS20026.1 - 2.5e-31 108.9 0.0 3e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 HORMA domain ATG101 PF07855.12 KOS20026.1 - 0.0084 16.1 0.1 0.029 14.4 0.1 2.0 1 1 0 1 1 1 1 Autophagy-related protein 101 DEAD PF00270.29 KOS20027.1 - 1.6e-51 174.6 0.0 9.6e-51 172.0 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS20027.1 - 4.1e-34 117.3 0.0 3.7e-31 107.7 0.1 2.9 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Caldesmon PF02029.15 KOS20027.1 - 0.025 13.3 48.1 0.038 12.8 48.1 1.2 1 0 0 1 1 1 0 Caldesmon bZIP_1 PF00170.21 KOS20028.1 - 0.0054 16.8 14.1 0.67 10.1 14.1 2.2 1 1 0 1 1 1 1 bZIP transcription factor GIT_CC PF16559.5 KOS20028.1 - 0.034 14.0 0.6 0.069 13.0 0.6 1.5 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor Paralemmin PF03285.15 KOS20028.1 - 0.1 12.2 0.4 0.15 11.6 0.4 1.3 1 0 0 1 1 1 0 Paralemmin Snf7 PF03357.21 KOS20028.1 - 0.66 9.5 3.5 0.96 9.0 3.5 1.2 1 0 0 1 1 1 0 Snf7 Glyco_hydro_3_C PF01915.22 KOS20029.1 - 7.2e-63 212.2 0.0 1.2e-62 211.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS20029.1 - 2.4e-44 152.0 0.0 3.9e-44 151.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS20029.1 - 1.8e-24 85.6 0.1 4.3e-24 84.4 0.1 1.7 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 KOS20029.1 - 9.9e-14 51.4 0.0 1.8e-13 50.5 0.0 1.4 1 0 0 1 1 1 1 PA14 domain FTA4 PF13093.6 KOS20030.1 - 4.5e-45 154.0 0.0 5.4e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 RPE65 PF03055.15 KOS20033.1 - 2.9e-115 386.1 0.0 3.6e-115 385.8 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein SR-25 PF10500.9 KOS20033.1 - 0.076 12.6 12.5 0.11 12.1 12.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 KOS20033.1 - 0.79 10.4 10.8 1.6 9.5 10.8 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein NifU_N PF01592.16 KOS20034.1 - 3.4e-54 182.4 0.1 4.6e-54 182.0 0.1 1.2 1 0 0 1 1 1 1 NifU-like N terminal domain bMG5 PF17972.1 KOS20034.1 - 0.018 15.4 0.0 0.027 14.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial Alpha-2-macroglobulin MG5 domain UCH PF00443.29 KOS20035.1 - 1.7e-37 129.4 0.0 2.3e-37 128.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 KOS20035.1 - 1.5e-22 79.7 10.6 5.6e-20 71.4 1.5 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 KOS20035.1 - 5.3e-21 74.1 1.3 5.3e-21 74.1 1.3 3.0 3 0 0 3 3 3 1 Variant UBP zinc finger UBA PF00627.31 KOS20035.1 - 1.8e-20 72.4 0.0 4e-09 36.2 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 KOS20035.1 - 3.4e-16 59.7 0.0 1.8e-15 57.4 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2180 PF09947.9 KOS20035.1 - 1.8 8.6 5.5 1.5 8.8 0.6 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) OxoDH_E1alpha_N PF12573.8 KOS20036.1 - 0.059 13.1 0.1 0.093 12.5 0.1 1.3 1 0 0 1 1 1 0 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal ABC_tran PF00005.27 KOS20037.1 - 1.2e-49 168.3 0.8 6.4e-25 88.3 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KOS20037.1 - 5.2e-22 78.4 40.3 4.6e-12 45.7 19.5 2.5 2 1 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 KOS20037.1 - 2.1e-20 73.8 6.8 1.1e-05 25.5 0.0 4.6 4 1 1 5 5 4 4 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOS20037.1 - 2.9e-08 33.3 4.3 0.00016 21.4 0.3 3.4 3 0 0 3 3 3 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS20037.1 - 8.4e-07 29.7 3.5 0.011 16.2 0.1 2.4 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 KOS20037.1 - 1.6e-06 27.8 4.5 0.053 12.9 0.1 4.2 4 0 0 4 4 4 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 KOS20037.1 - 5.1e-05 23.2 0.1 0.39 10.6 0.1 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_30 PF13604.6 KOS20037.1 - 9.6e-05 22.2 0.4 0.081 12.6 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 KOS20037.1 - 0.0001 22.1 0.2 0.48 10.1 0.0 3.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_16 PF13191.6 KOS20037.1 - 0.0006 20.2 0.2 0.95 9.8 0.1 2.9 2 0 0 2 2 2 2 AAA ATPase domain AAA_27 PF13514.6 KOS20037.1 - 0.004 16.8 0.7 2.1 7.9 0.1 2.5 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 KOS20037.1 - 0.017 14.7 1.2 2.4 7.7 0.1 2.7 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_22 PF13401.6 KOS20037.1 - 0.04 14.2 1.2 6.6 7.0 0.1 3.4 3 1 0 3 3 3 0 AAA domain AAA_28 PF13521.6 KOS20037.1 - 0.054 13.7 0.5 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOS20037.1 - 0.069 12.4 0.4 12 5.1 0.1 2.5 2 0 0 2 2 2 0 Zeta toxin AAA_18 PF13238.6 KOS20037.1 - 0.1 13.1 0.1 27 5.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 KOS20037.1 - 0.13 11.8 1.1 35 3.9 0.1 3.3 3 0 0 3 3 3 0 AAA domain MukB PF04310.12 KOS20037.1 - 0.34 10.7 1.6 16 5.2 0.3 2.3 2 0 0 2 2 2 0 MukB N-terminal DUF87 PF01935.17 KOS20037.1 - 0.45 10.6 2.7 16 5.5 0.3 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_19 PF13245.6 KOS20037.1 - 0.6 10.4 2.2 22 5.3 0.1 3.2 3 0 0 3 3 3 0 AAA domain Acyltransferase PF01553.21 KOS20038.1 - 3e-09 36.6 0.0 4.6e-05 23.0 0.0 2.3 2 0 0 2 2 2 2 Acyltransferase Suc_Fer-like PF06999.12 KOS20039.1 - 5.5e-67 225.4 0.0 6.4e-67 225.2 0.0 1.0 1 0 0 1 1 1 1 Sucrase/ferredoxin-like DARPP-32 PF05395.12 KOS20039.1 - 1.7e-05 25.1 1.4 2.6e-05 24.5 1.4 1.2 1 0 0 1 1 1 1 Protein phosphatase inhibitor 1/DARPP-32 RPA43_OB PF17875.1 KOS20039.1 - 0.0019 18.8 0.9 0.0027 18.3 0.9 1.3 1 0 0 1 1 1 1 RPA43 OB domain in RNA Pol I RNA_pol_Rpc4 PF05132.14 KOS20039.1 - 0.0071 16.8 0.7 0.011 16.2 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 DUF5523 PF17661.1 KOS20039.1 - 0.0074 16.0 13.2 0.01 15.5 13.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5523) DNA_pol_phi PF04931.13 KOS20039.1 - 0.014 13.6 13.5 0.017 13.2 13.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi SpoIIP PF07454.11 KOS20039.1 - 0.017 14.6 3.4 0.023 14.2 3.4 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) BUD22 PF09073.10 KOS20039.1 - 0.021 14.2 10.8 0.027 13.8 10.8 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 KOS20039.1 - 0.033 13.6 13.9 0.044 13.2 13.9 1.1 1 0 0 1 1 1 0 SDA1 GEN1_C PF18380.1 KOS20039.1 - 0.034 15.0 11.2 1.5 9.7 11.3 2.2 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain CPSF100_C PF13299.6 KOS20039.1 - 0.051 13.8 3.2 0.077 13.2 3.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Myc_N PF01056.18 KOS20039.1 - 0.068 13.1 4.7 0.1 12.5 4.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region RPN2_C PF18004.1 KOS20039.1 - 0.075 12.9 12.1 0.11 12.4 12.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain EIIBC-GUT_N PF03612.14 KOS20039.1 - 0.18 11.6 1.2 0.27 10.9 1.2 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 KOS20039.1 - 0.26 10.0 2.6 0.34 9.6 2.6 1.1 1 0 0 1 1 1 0 Presenilin Paf1 PF03985.13 KOS20039.1 - 0.32 9.9 18.6 0.42 9.6 18.6 1.1 1 0 0 1 1 1 0 Paf1 DUF913 PF06025.12 KOS20039.1 - 0.35 9.8 2.1 0.5 9.3 2.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RAB3GAP2_C PF14656.6 KOS20039.1 - 0.37 9.0 1.4 0.49 8.6 1.4 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Nop14 PF04147.12 KOS20039.1 - 0.48 8.6 15.8 0.65 8.1 15.8 1.0 1 0 0 1 1 1 0 Nop14-like family Fer4_9 PF13187.6 KOS20039.1 - 0.55 10.4 3.4 4 7.7 0.6 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain CDC45 PF02724.14 KOS20039.1 - 0.68 8.2 10.7 0.91 7.7 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOS20039.1 - 0.73 9.1 10.9 1.7 7.9 11.2 1.4 2 0 0 2 2 1 0 NOA36 protein Pox_Ag35 PF03286.14 KOS20039.1 - 1.1 9.1 13.0 1.7 8.4 13.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Fer4_13 PF13370.6 KOS20039.1 - 1.4 9.5 0.0 1.4 9.5 0.0 3.3 3 1 0 3 3 2 0 4Fe-4S single cluster domain of Ferredoxin I Connexin PF00029.19 KOS20039.1 - 1.4 8.6 6.7 2.1 8.1 6.7 1.1 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 KOS20039.1 - 1.6 8.4 11.3 2.8 7.6 11.3 1.3 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 KOS20039.1 - 1.6 7.8 9.2 2.4 7.3 9.2 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1644 PF07800.12 KOS20039.1 - 1.6 8.7 6.2 2.2 8.3 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Radial_spoke PF04712.12 KOS20039.1 - 1.7 7.5 13.3 2.8 6.8 13.3 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein V_ATPase_I PF01496.19 KOS20039.1 - 2.1 6.2 4.9 2.7 5.8 4.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Eapp_C PF10238.9 KOS20039.1 - 2.3 8.3 8.3 3.9 7.6 8.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein NPR3 PF03666.13 KOS20039.1 - 3 6.5 5.8 4.1 6.1 5.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 KOS20039.1 - 5.4 7.3 14.0 8.4 6.7 14.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_polI_A34 PF08208.11 KOS20039.1 - 6.4 6.8 20.1 9.9 6.2 20.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 KOS20039.1 - 7.4 6.3 15.3 11 5.8 15.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 KOS20039.1 - 8.7 5.0 12.7 13 4.5 12.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 KOS20039.1 - 9.4 5.3 5.5 14 4.8 5.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Chromo_shadow PF01393.19 KOS20041.1 - 4.6e-19 68.2 2.0 3.7e-16 59.0 0.2 2.5 2 0 0 2 2 2 2 Chromo shadow domain Chromo PF00385.24 KOS20041.1 - 1.6e-12 47.1 0.9 1.6e-12 47.1 0.9 2.8 3 0 0 3 3 3 1 Chromo (CHRromatin Organisation MOdifier) domain DUF1501 PF07394.12 KOS20041.1 - 0.012 14.7 0.1 0.016 14.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) NOA36 PF06524.12 KOS20041.1 - 0.6 9.4 6.4 0.84 8.9 6.4 1.2 1 0 0 1 1 1 0 NOA36 protein COX15-CtaA PF02628.15 KOS20042.1 - 4.7e-114 380.8 4.2 5.8e-114 380.5 4.2 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein Utp14 PF04615.13 KOS20043.1 - 5.3e-189 630.4 75.0 5.3e-189 630.4 75.0 3.0 1 1 1 2 2 2 1 Utp14 protein Glyco_hydro_81 PF03639.13 KOS20044.1 - 1.5e-85 287.2 0.0 2.5e-85 286.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain Glyco_hydro81C PF17652.1 KOS20044.1 - 1.3e-76 258.1 4.2 1.8e-76 257.7 4.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain DnaJ PF00226.31 KOS20045.1 - 3e-21 75.3 1.2 9.6e-21 73.7 1.2 1.9 1 0 0 1 1 1 1 DnaJ domain Tom6 PF17112.5 KOS20046.1 - 0.0078 15.7 0.1 0.0092 15.5 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal MFS_1 PF07690.16 KOS20047.1 - 2.5e-32 112.2 22.5 2.9e-16 59.4 9.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KOS20047.1 - 7e-08 31.4 21.6 0.0039 15.8 0.1 3.6 3 1 1 4 4 4 3 MFS/sugar transport protein MFS_1_like PF12832.7 KOS20047.1 - 8.1e-05 21.6 9.8 0.073 11.9 0.1 2.3 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 KOS20047.1 - 0.00017 20.6 14.7 0.0076 15.2 7.0 3.1 1 1 2 3 3 3 3 Sugar (and other) transporter OATP PF03137.20 KOS20047.1 - 0.041 12.2 9.2 4.6 5.4 0.1 3.7 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Sugar_tr PF00083.24 KOS20049.1 - 4.6e-114 381.8 21.4 5.3e-114 381.6 21.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS20049.1 - 1.4e-16 60.4 34.5 1.4e-16 60.4 34.5 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MCM PF00493.23 KOS20050.1 - 5.5e-98 326.5 1.0 6.3e-98 326.3 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 KOS20050.1 - 5e-39 133.0 0.2 9e-39 132.2 0.2 1.4 1 0 0 1 1 1 1 MCM OB domain MCM2_N PF12619.8 KOS20050.1 - 1e-33 116.8 30.8 1e-33 116.8 30.8 2.3 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 KOS20050.1 - 4.8e-14 52.8 0.1 1.1e-13 51.6 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain MCM_lid PF17855.1 KOS20050.1 - 2.5e-08 34.2 0.1 6e-08 33.0 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 KOS20050.1 - 1.6e-07 31.0 0.0 6.5e-06 25.7 0.0 2.4 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 KOS20050.1 - 7.6e-06 26.0 0.0 1.5e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 KOS20050.1 - 0.0055 16.6 0.1 0.028 14.3 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS20050.1 - 0.007 16.1 0.2 0.043 13.5 0.2 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Zn_ribbon_2 PF12674.7 KOS20050.1 - 0.23 12.2 0.4 0.53 11.0 0.4 1.6 1 0 0 1 1 1 0 Putative zinc ribbon domain DUF3113 PF11310.8 KOS20050.1 - 0.24 11.3 0.0 0.24 11.3 0.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3113) zf-TFIIB PF13453.6 KOS20050.1 - 0.46 9.9 1.9 0.97 8.8 1.9 1.6 1 0 0 1 1 1 0 Transcription factor zinc-finger Ctr PF04145.15 KOS20051.1 - 0.1 13.2 0.0 0.74 10.4 0.0 2.0 1 1 1 2 2 2 0 Ctr copper transporter family Carboxyl_trans PF01039.22 KOS20052.1 - 1.8e-136 455.7 0.1 2.3e-136 455.3 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 KOS20052.1 - 0.02 14.4 3.7 0.33 10.4 0.0 2.6 3 0 0 3 3 3 0 Malonate decarboxylase gamma subunit (MdcE) DJ-1_PfpI PF01965.24 KOS20052.1 - 0.023 14.5 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 DJ-1/PfpI family Acyl-CoA_dh_1 PF00441.24 KOS20053.1 - 2.3e-42 144.7 2.0 3.9e-42 144.0 2.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOS20053.1 - 6.8e-31 107.3 0.1 1.4e-30 106.3 0.1 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOS20053.1 - 3.1e-25 88.2 0.0 6.5e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOS20053.1 - 4.6e-14 52.8 0.7 9.3e-14 51.9 0.7 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KOS20053.1 - 0.00071 19.3 0.0 0.0016 18.1 0.0 1.6 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal zf-met2 PF12907.7 KOS20053.1 - 0.25 11.5 0.0 0.57 10.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding His_Phos_1 PF00300.22 KOS20054.1 - 2e-19 70.1 0.0 2.8e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Med15 PF09606.10 KOS20055.1 - 1.4 7.6 5.3 2 7.0 5.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal HlyD_D4 PF16572.5 KOS20055.1 - 1.8 8.5 4.4 0.59 10.0 0.5 2.3 3 0 0 3 3 3 0 Long alpha hairpin domain of cation efflux system protein, CusB ABC_tran_CTD PF16326.5 KOS20056.1 - 0.1 12.9 0.0 0.1 12.9 0.0 3.4 3 2 2 5 5 5 0 ABC transporter C-terminal domain Zn_clus PF00172.18 KOS20057.1 - 2.5e-07 30.7 11.5 4.6e-07 29.9 11.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 KOS20057.1 - 0.0069 15.0 31.8 0.009 14.6 31.8 1.2 1 0 0 1 1 1 1 Macoilin family Mem_trans PF03547.18 KOS20057.1 - 0.5 8.7 9.4 0.66 8.3 9.4 1.2 1 0 0 1 1 1 0 Membrane transport protein SLC12 PF03522.15 KOS20057.1 - 0.64 9.0 38.4 1.1 8.2 38.4 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Caldesmon PF02029.15 KOS20057.1 - 2.9 6.5 43.5 4.5 5.9 43.5 1.2 1 0 0 1 1 1 0 Caldesmon GREB1 PF15782.5 KOS20057.1 - 4.6 4.2 40.1 6.2 3.8 40.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Asp-B-Hydro_N PF05279.11 KOS20057.1 - 5.5 7.0 31.5 8.3 6.4 31.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BAF1_ABF1 PF04684.13 KOS20057.1 - 5.9 5.8 37.2 8.3 5.3 37.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DUF572 PF04502.13 KOS20057.1 - 9.8 5.7 37.1 22 4.5 37.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF572) GTP_EFTU PF00009.27 KOS20059.1 - 3.3e-50 170.3 0.0 4.9e-50 169.8 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 KOS20059.1 - 3e-44 149.5 1.3 5.1e-44 148.8 1.3 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 KOS20059.1 - 6.1e-20 71.1 0.0 1.1e-19 70.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus MMR_HSR1 PF01926.23 KOS20059.1 - 8.4e-05 22.6 0.0 0.00019 21.5 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase EFG_II PF14492.6 KOS20059.1 - 0.00012 22.1 0.0 0.00027 21.0 0.0 1.7 1 1 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 KOS20059.1 - 0.0002 21.7 0.1 0.00045 20.6 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 Ras PF00071.22 KOS20059.1 - 0.0018 17.9 0.0 0.0087 15.7 0.0 2.0 2 0 0 2 2 2 1 Ras family RF3_C PF16658.5 KOS20059.1 - 0.042 13.7 0.0 0.098 12.5 0.0 1.6 1 0 0 1 1 1 0 Class II release factor RF3, C-terminal domain Roc PF08477.13 KOS20059.1 - 0.062 13.5 0.0 0.83 9.9 0.0 2.5 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 KOS20059.1 - 0.1 12.0 0.0 0.26 10.7 0.0 1.6 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Snurportin1 PF11538.8 KOS20059.1 - 0.37 11.0 2.4 0.75 10.0 2.4 1.4 1 0 0 1 1 1 0 Snurportin1 MIT PF04212.18 KOS20060.1 - 3.6e-13 49.4 2.8 6.6e-13 48.5 2.8 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain vATP-synt_E PF01991.18 KOS20061.1 - 2.5e-65 219.6 5.7 2.9e-65 219.4 5.7 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit DUF4303 PF14136.6 KOS20061.1 - 0.053 13.3 0.8 0.12 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4303) SurA_N_3 PF13624.6 KOS20061.1 - 0.61 9.9 6.6 3.8 7.3 5.5 2.3 2 1 0 2 2 2 0 SurA N-terminal domain BUD22 PF09073.10 KOS20063.1 - 1.4e-78 265.1 78.5 2.1e-77 261.3 78.5 2.4 1 1 0 1 1 1 1 BUD22 SAGA-Tad1 PF12767.7 KOS20063.1 - 2.4 7.8 9.9 0.27 10.9 0.7 2.6 2 0 0 2 2 2 0 Transcriptional regulator of RNA polII, SAGA, subunit Sporozoite_P67 PF05642.11 KOS20063.1 - 2.9 5.9 22.7 1.7 6.7 7.1 2.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Rad4 PF03835.15 KOS20065.1 - 1.7e-28 99.2 0.0 4.5e-28 97.8 0.0 1.7 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 KOS20065.1 - 1e-26 93.1 0.1 2e-26 92.2 0.1 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 KOS20065.1 - 1.2e-22 79.5 0.0 2.4e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 KOS20065.1 - 3.4e-18 66.4 0.4 3.4e-18 66.4 0.4 4.7 3 1 0 3 3 3 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 KOS20065.1 - 3.5e-05 24.2 0.2 0.0011 19.4 0.2 2.6 1 1 0 1 1 1 1 Transglutaminase-like superfamily SDA1 PF05285.12 KOS20065.1 - 4.2 6.7 26.0 2.8 7.3 6.9 2.3 2 0 0 2 2 2 0 SDA1 Mito_carr PF00153.27 KOS20066.1 - 2.9e-51 171.3 4.7 2.4e-16 59.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ABC1 PF03109.16 KOS20067.1 - 2.2e-23 82.7 0.0 1.6e-14 54.1 0.0 2.4 2 0 0 2 2 2 2 ABC1 family SR-25 PF10500.9 KOS20067.1 - 1.7 8.2 3.7 2.8 7.5 3.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TCO89 PF10452.9 KOS20068.1 - 2.6e-05 23.4 0.5 0.00056 19.0 0.0 3.2 3 0 0 3 3 3 2 TORC1 subunit TCO89 DbpA PF03880.15 KOS20069.1 - 0.0076 16.2 0.1 0.016 15.2 0.1 1.6 1 0 0 1 1 1 1 DbpA RNA binding domain Cyto_heme_lyase PF01265.17 KOS20070.1 - 1.2e-112 376.2 0.4 1.4e-112 376.0 0.4 1.0 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase PseudoU_synth_2 PF00849.22 KOS20071.1 - 6.6e-29 101.0 0.3 1.2e-28 100.2 0.0 1.6 2 0 0 2 2 2 1 RNA pseudouridylate synthase S4 PF01479.25 KOS20071.1 - 0.0025 17.5 0.0 0.0025 17.5 0.0 2.3 3 0 0 3 3 3 1 S4 domain Ub-Mut7C PF14451.6 KOS20071.1 - 0.16 11.9 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Mut7-C ubiquitin Na_Ca_ex PF01699.24 KOS20072.1 - 1.6e-46 158.0 37.1 1.1e-24 87.1 16.8 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Flp1_like PF16982.5 KOS20072.1 - 2.9 7.3 8.4 0.079 12.4 0.5 2.6 3 0 0 3 3 3 0 Putative Flagellin, Flp1-like, domain Glyco_hydro81C PF17652.1 KOS20073.1 - 3e-63 214.2 0.2 3.3e-63 214.0 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain BRCT_2 PF16589.5 KOS20074.1 - 7.5e-05 23.1 0.0 0.00012 22.4 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 KOS20074.1 - 0.00021 21.2 0.3 0.00061 19.7 0.3 1.9 1 1 0 1 1 1 1 twin BRCT domain Bcl-2_BAD PF10514.9 KOS20074.1 - 0.0015 19.0 0.4 0.0015 19.0 0.4 1.6 2 0 0 2 2 2 1 Pro-apoptotic Bcl-2 protein, BAD DUF3474 PF11960.8 KOS20074.1 - 0.0041 17.3 2.5 0.0046 17.1 0.9 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3474) PRIMA1 PF16101.5 KOS20074.1 - 6.7 6.8 6.7 12 6.0 6.7 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Sdh5 PF03937.16 KOS20075.1 - 2.3e-25 88.4 0.1 7.5e-25 86.7 0.1 1.7 2 0 0 2 2 2 1 Flavinator of succinate dehydrogenase ADH_zinc_N PF00107.26 KOS20076.1 - 1.4e-26 93.0 0.4 2e-26 92.5 0.4 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS20076.1 - 5.1e-20 72.9 0.0 8.2e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DapB_N PF01113.20 KOS20076.1 - 0.037 14.2 0.1 0.15 12.2 0.1 1.9 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Amidase_2 PF01510.25 KOS20076.1 - 0.056 13.9 0.1 0.081 13.4 0.1 1.4 1 1 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase GCHY-1 PF02649.14 KOS20077.1 - 2.9 7.3 4.2 0.84 9.1 0.5 1.6 1 1 1 2 2 2 0 Type I GTP cyclohydrolase folE2 Rep_fac-A_C PF08646.10 KOS20078.1 - 1.1e-50 171.1 7.0 1.8e-49 167.2 4.7 2.4 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 KOS20078.1 - 3.2e-37 126.4 2.8 1e-36 124.8 1.6 2.4 3 0 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.12 KOS20078.1 - 6.2e-24 83.9 0.1 3.3e-23 81.6 0.0 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain tRNA_anti-codon PF01336.25 KOS20078.1 - 2e-16 59.7 1.5 6.4e-12 45.3 0.0 3.4 2 1 0 3 3 3 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 KOS20078.1 - 5e-07 29.7 1.8 9e-05 22.3 0.1 3.2 4 0 0 4 4 4 1 Cell division control protein 24, OB domain 3 POT1 PF02765.17 KOS20078.1 - 0.0013 18.6 0.2 0.024 14.5 0.1 2.5 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 DUF4503 PF14951.6 KOS20078.1 - 0.024 13.1 0.1 0.039 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) DUF223 PF02721.14 KOS20078.1 - 0.036 14.4 0.0 0.12 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF223 zf-like PF04071.12 KOS20078.1 - 0.053 13.4 2.0 0.12 12.3 2.0 1.5 1 0 0 1 1 1 0 Cysteine-rich small domain zf-U1 PF06220.12 KOS20079.1 - 3.2e-22 78.0 3.4 5.3e-22 77.3 3.4 1.4 1 0 0 1 1 1 1 U1 zinc finger Actin_micro PF17003.5 KOS20079.1 - 0.21 10.7 0.1 0.24 10.5 0.1 1.0 1 0 0 1 1 1 0 Putative actin-like family MCPVI PF02993.14 KOS20080.1 - 2.1 8.1 5.8 3.5 7.4 5.8 1.3 1 0 0 1 1 1 0 Minor capsid protein VI MIS13 PF08202.11 KOS20081.1 - 1.3e-54 185.5 2.1 5.2e-54 183.6 0.0 2.4 2 0 0 2 2 2 1 Mis12-Mtw1 protein family Trypan_PARP PF05887.11 KOS20081.1 - 0.00024 21.1 19.4 0.00024 21.1 19.4 3.6 2 1 1 4 4 4 1 Procyclic acidic repetitive protein (PARP) EMP24_GP25L PF01105.24 KOS20082.1 - 1.2e-39 136.1 0.0 1.3e-39 136.0 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD TAL_FSA PF00923.19 KOS20083.1 - 6.3e-25 88.1 0.0 8.1e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase GTA_TIM PF13547.6 KOS20083.1 - 0.04 13.2 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 GTA TIM-barrel-like domain PDT PF00800.18 KOS20083.1 - 0.16 11.7 0.9 2.9 7.7 0.1 2.6 2 1 1 3 3 3 0 Prephenate dehydratase GCFC PF07842.12 KOS20084.1 - 4.2e-65 220.1 3.4 4.4e-65 220.0 2.7 1.3 1 1 0 1 1 1 1 GC-rich sequence DNA-binding factor-like protein G-patch PF01585.23 KOS20084.1 - 8.1e-14 51.2 1.5 8.1e-14 51.2 1.5 2.4 2 0 0 2 2 2 1 G-patch domain TIP_N PF12457.8 KOS20084.1 - 8.9e-12 45.3 6.5 8.9e-12 45.3 6.5 4.0 4 1 0 4 4 4 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 KOS20084.1 - 3.2e-08 33.5 3.2 4.8e-08 33.0 0.5 2.7 2 0 0 2 2 2 1 G-patch domain DNA_pol_phi PF04931.13 KOS20084.1 - 2.3 6.2 7.2 5.4 5.0 7.2 1.6 1 0 0 1 1 1 0 DNA polymerase phi DUF3429 PF11911.8 KOS20085.1 - 3.1e-46 157.3 4.7 3.9e-46 156.9 4.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3429) Peptidase_S49_N PF08496.10 KOS20085.1 - 0.072 13.2 2.6 0.13 12.3 2.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ctr PF04145.15 KOS20085.1 - 0.081 13.5 0.2 0.17 12.5 0.0 1.7 2 0 0 2 2 2 0 Ctr copper transporter family V_ATPase_I PF01496.19 KOS20085.1 - 0.14 10.1 0.3 0.19 9.6 0.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Methyltransf_4 PF02390.17 KOS20085.1 - 0.17 11.4 3.4 0.28 10.6 3.4 1.3 1 0 0 1 1 1 0 Putative methyltransferase Zip PF02535.22 KOS20085.1 - 0.18 11.0 0.9 0.29 10.3 0.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 KOS20085.1 - 0.4 9.4 7.8 0.76 8.5 7.8 1.3 1 0 0 1 1 1 0 Raftlin NARP1 PF12569.8 KOS20085.1 - 0.91 8.4 9.5 1.3 7.8 9.5 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Connexin PF00029.19 KOS20085.1 - 2.3 7.9 3.1 3.7 7.2 3.1 1.4 1 0 0 1 1 1 0 Connexin zf-CCHC PF00098.23 KOS20086.1 - 0.00098 19.1 15.0 0.028 14.5 0.9 3.3 3 0 0 3 3 3 2 Zinc knuckle SpoIIIAH PF12685.7 KOS20086.1 - 0.08 12.8 0.1 0.08 12.8 0.1 2.1 1 1 1 2 2 2 0 SpoIIIAH-like protein Ndufs5 PF10200.9 KOS20086.1 - 0.18 12.1 0.3 0.65 10.3 0.0 2.0 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa zf-CCHC_5 PF14787.6 KOS20086.1 - 0.92 9.3 9.1 0.6 9.9 0.1 3.4 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger RRM_1 PF00076.22 KOS20087.1 - 1.9e-17 62.8 0.0 1.2e-11 44.3 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS20087.1 - 0.017 15.2 0.1 0.13 12.4 0.1 2.3 2 1 0 2 2 2 0 RNA recognition motif RRM_Rrp7 PF17799.1 KOS20087.1 - 0.019 14.7 0.0 4.9 6.9 0.0 2.6 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Zip PF02535.22 KOS20087.1 - 9.8 5.3 7.8 9.9 5.3 1.0 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter SUR7 PF06687.12 KOS20088.1 - 3.7e-18 65.9 5.1 3.7e-18 65.9 5.1 1.4 1 1 0 1 1 1 1 SUR7/PalI family ORMDL PF04061.14 KOS20089.1 - 4e-59 198.3 5.0 4.9e-59 198.0 5.0 1.1 1 0 0 1 1 1 1 ORMDL family Med1 PF10744.9 KOS20090.1 - 3e-116 388.9 0.0 9.3e-116 387.3 0.0 1.7 2 0 0 2 2 2 1 Mediator of RNA polymerase II transcription subunit 1 Suf PF05843.14 KOS20090.1 - 2.8 7.8 5.9 5.5 6.9 5.9 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Med15_fungi PF05397.12 KOS20091.1 - 0.044 14.0 0.0 0.12 12.7 0.0 1.6 2 0 0 2 2 2 0 Mediator complex subunit 15 MFS_1 PF07690.16 KOS20092.1 - 2.2e-31 109.1 60.7 2.2e-27 95.9 38.9 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS20092.1 - 1.2e-20 73.8 22.7 1.3e-16 60.5 6.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter zf-PHD-like PF15446.6 KOS20093.1 - 1.3e-64 216.9 19.5 1.3e-64 216.9 19.5 1.6 2 0 0 2 2 2 1 PHD/FYVE-zinc-finger like domain SNF2_N PF00176.23 KOS20093.1 - 9.6e-52 175.8 0.1 1.7e-51 175.0 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS20093.1 - 2.3e-19 69.8 0.0 2.6e-18 66.4 0.0 2.5 3 0 0 3 3 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KOS20093.1 - 7.5e-10 38.4 0.6 2e-09 37.0 0.6 1.6 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 KOS20093.1 - 8.4e-07 29.1 0.0 1.7e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Chromo PF00385.24 KOS20093.1 - 1e-06 28.6 0.3 2.9e-05 23.9 0.5 2.7 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 KOS20093.1 - 4.2e-05 23.4 8.9 4.2e-05 23.4 8.9 3.9 2 2 2 4 4 3 1 PHD-finger DEAD PF00270.29 KOS20093.1 - 0.00026 20.8 0.0 0.00057 19.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase PHD_2 PF13831.6 KOS20093.1 - 0.0013 18.2 0.4 0.0013 18.2 0.4 3.7 4 1 0 4 4 3 1 PHD-finger Zf_RING PF16744.5 KOS20093.1 - 1.3 9.2 16.4 3.2 7.9 6.3 2.6 2 0 0 2 2 2 0 KIAA1045 RING finger PHD_4 PF16866.5 KOS20093.1 - 4.6 7.4 19.8 0.56 10.3 2.3 3.4 1 1 2 3 3 3 0 PHD-finger SDA1 PF05285.12 KOS20094.1 - 1.5 8.2 7.6 1.8 7.9 7.6 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 KOS20094.1 - 2.1 6.4 7.5 2.2 6.4 7.5 1.0 1 0 0 1 1 1 0 Nop14-like family SpoU_methylase PF00588.19 KOS20095.1 - 9.4e-21 74.5 0.0 1.6e-20 73.7 0.0 1.3 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 KOS20095.1 - 5.5e-10 39.4 0.0 1.1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding UPF0113 PF03657.13 KOS20095.1 - 0.14 12.4 0.0 0.32 11.3 0.0 1.6 1 0 0 1 1 1 0 UPF0113 PUA domain HET PF06985.11 KOS20096.1 - 1.2e-10 41.9 0.0 2.2e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) APG17 PF04108.12 KOS20096.1 - 0.26 10.4 0.0 0.38 9.8 0.0 1.1 1 0 0 1 1 1 0 Autophagy protein Apg17 RNA_Me_trans PF04252.13 KOS20097.1 - 7e-55 185.7 0.0 7.8e-33 113.7 0.0 2.0 1 1 1 2 2 2 2 Predicted SAM-dependent RNA methyltransferase DUF4595 PF15283.6 KOS20097.1 - 0.17 11.9 0.0 0.2 11.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4595) with porin-like fold DLH PF01738.18 KOS20098.1 - 2.4e-17 63.2 0.3 1.8e-16 60.4 0.3 2.1 1 1 0 1 1 1 1 Dienelactone hydrolase family HMG-CoA_red PF00368.18 KOS20099.1 - 1.6e-25 90.0 1.6 1.9e-25 89.7 1.6 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Isochorismatase PF00857.20 KOS20100.1 - 5.8e-23 81.9 0.2 5.7e-22 78.7 0.2 2.0 1 1 0 1 1 1 1 Isochorismatase family RSN1_7TM PF02714.15 KOS20101.1 - 8.3e-40 136.8 15.6 1.2e-23 83.9 1.3 3.1 1 1 2 3 3 3 3 Calcium-dependent channel, 7TM region, putative phosphate PHM7_ext PF12621.8 KOS20101.1 - 6.8e-24 83.9 0.9 1.2e-23 83.1 0.1 1.8 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 KOS20101.1 - 2.3e-05 24.7 0.0 5.6e-05 23.5 0.0 1.7 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Aminotran_5 PF00266.19 KOS20102.1 - 3.8e-10 39.3 0.0 6.5e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS20102.1 - 0.0014 18.1 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_3 PF00202.21 KOS20102.1 - 0.071 11.8 0.0 0.1 11.2 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-III Thioredoxin PF00085.20 KOS20103.1 - 3.3e-29 100.9 0.0 1.3e-24 86.2 0.0 2.4 2 0 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 KOS20103.1 - 2.3e-06 28.0 0.0 0.0084 16.6 0.0 2.6 2 0 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOS20103.1 - 0.00039 20.7 0.0 9.7 6.6 0.0 4.1 3 1 1 4 4 4 1 Thioredoxin-like OST3_OST6 PF04756.13 KOS20103.1 - 0.0037 16.7 0.0 0.099 12.0 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family TraF PF13728.6 KOS20103.1 - 0.022 14.6 0.0 0.022 14.6 0.0 3.7 4 0 0 4 4 4 0 F plasmid transfer operon protein Thioredoxin_7 PF13899.6 KOS20103.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Calsequestrin PF01216.17 KOS20103.1 - 0.042 12.9 0.0 0.11 11.5 0.0 1.7 2 1 0 2 2 2 0 Calsequestrin Roughex PF06020.11 KOS20103.1 - 0.082 12.0 2.4 0.15 11.2 2.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein RNase_PH PF01138.21 KOS20104.1 - 1.4e-34 119.4 0.1 2.2e-34 118.8 0.1 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 2OG-FeII_Oxy PF03171.20 KOS20105.1 - 1.7e-19 70.2 0.0 3.2e-19 69.3 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 KOS20105.1 - 1.8e-13 51.2 0.0 4.3e-13 50.0 0.0 1.6 1 1 1 2 2 2 1 non-haem dioxygenase in morphine synthesis N-terminal IDO PF01231.18 KOS20106.1 - 3.5e-145 484.1 0.0 4e-145 483.9 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase DUF1864 PF08933.11 KOS20106.1 - 0.091 11.5 0.0 0.46 9.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1864) EVE PF01878.18 KOS20107.1 - 2e-48 164.1 0.0 3.3e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 EVE domain DUF2981 PF11200.8 KOS20107.1 - 0.85 9.3 2.5 1.1 8.9 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Glyco_hydro_16 PF00722.21 KOS20108.1 - 1.8e-07 30.8 0.0 5.1e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Formyl_trans_N PF00551.19 KOS20109.1 - 4.2e-08 33.2 0.0 3.8e-07 30.0 0.0 2.2 1 1 0 1 1 1 1 Formyl transferase MBF1 PF08523.10 KOS20111.1 - 4.3e-25 88.0 1.2 4.3e-25 88.0 1.2 1.6 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 KOS20111.1 - 1.6e-11 44.1 0.3 2.7e-11 43.4 0.3 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 KOS20111.1 - 0.00012 22.3 0.4 0.00022 21.5 0.4 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MRC1 PF09444.10 KOS20112.1 - 1e-39 136.3 17.0 1e-39 136.3 17.0 5.6 6 1 1 7 7 7 1 MRC1-like domain CAP_N PF01213.19 KOS20112.1 - 0.063 12.7 8.1 0.27 10.7 8.1 2.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Pap_E4 PF02711.14 KOS20112.1 - 4.3 8.4 12.5 1.5 9.9 5.3 3.5 2 0 0 2 2 2 0 E4 protein DUF2207 PF09972.9 KOS20113.1 - 0.0027 16.5 0.0 0.0041 16.0 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Ac76 PF05814.11 KOS20113.1 - 0.092 12.8 1.3 0.17 11.9 1.3 1.4 1 0 0 1 1 1 0 Orf76 (Ac76) TMEM154 PF15102.6 KOS20113.1 - 0.18 11.7 0.6 0.43 10.5 0.6 1.7 1 1 0 1 1 1 0 TMEM154 protein family NAD_binding_5 PF07994.12 KOS20114.1 - 1.3e-146 488.1 0.2 1.5e-146 487.9 0.2 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 KOS20114.1 - 2.3e-45 153.3 0.8 5.2e-45 152.2 0.6 1.8 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase DUF3405 PF11885.8 KOS20115.1 - 1.7e-185 617.6 7.4 2.2e-185 617.2 7.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) GATase_5 PF13507.6 KOS20116.1 - 2.4e-99 331.7 0.0 3.4e-99 331.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 KOS20116.1 - 1.6e-34 119.3 0.9 2.2e-23 83.1 0.2 3.3 4 0 0 4 4 4 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 KOS20116.1 - 2.5e-25 88.7 0.0 5.5e-25 87.6 0.0 1.6 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 KOS20116.1 - 3.4e-22 78.7 0.1 9.1e-22 77.3 0.1 1.8 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain SpdB PF05122.13 KOS20116.1 - 0.038 14.1 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Mobile element transfer protein Pyridoxal_deC PF00282.19 KOS20117.1 - 1.1e-24 86.9 0.0 1.5e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 KOS20117.1 - 0.16 11.1 0.0 0.26 10.4 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Aminotran_5 PF00266.19 KOS20117.1 - 0.2 10.6 0.0 0.4 9.6 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V Sulfatase PF00884.23 KOS20118.1 - 4e-20 72.4 0.9 6.3e-20 71.8 0.9 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 KOS20118.1 - 7.6e-06 25.7 0.5 1.7e-05 24.6 0.3 1.4 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KOS20118.1 - 0.00056 18.6 0.0 0.00083 18.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) RseC_MucC PF04246.12 KOS20118.1 - 0.76 9.7 2.8 2 8.3 2.8 1.7 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Peptidase_U4 PF03419.13 KOS20118.1 - 1.2 8.3 4.4 2.4 7.4 4.4 1.4 1 0 0 1 1 1 0 Sporulation factor SpoIIGA SUR7 PF06687.12 KOS20118.1 - 4.1 7.0 9.4 10 5.7 8.8 2.0 2 0 0 2 2 2 0 SUR7/PalI family TPR_12 PF13424.6 KOS20119.1 - 1e-10 41.7 4.0 0.00043 20.5 0.0 4.9 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOS20119.1 - 0.00017 21.3 1.7 4.2 7.4 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20119.1 - 0.002 18.1 3.1 3.8 7.9 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS20119.1 - 0.0048 16.8 1.1 0.37 10.9 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20119.1 - 0.11 13.2 1.4 0.69 10.6 0.6 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Cut8 PF08559.10 KOS20120.1 - 9.5e-51 172.7 0.0 1.1e-50 172.5 0.0 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Rad52_Rad22 PF04098.15 KOS20121.1 - 2.5e-58 196.3 0.0 3.3e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein DUF2985 PF11204.8 KOS20123.1 - 3.3e-22 78.4 3.1 2.2e-21 75.8 3.9 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2985) Sulfate_transp PF00916.20 KOS20124.1 - 2.2e-112 375.6 18.6 3e-112 375.1 18.6 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOS20124.1 - 4.2e-10 39.3 0.0 8.3e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KOS20124.1 - 0.075 13.4 22.3 0.063 13.7 4.2 3.8 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 KOS20124.1 - 0.1 12.9 0.4 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 STAS domain DUF3439 PF11921.8 KOS20124.1 - 0.15 12.0 12.0 0.46 10.5 12.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 KOS20124.1 - 0.35 8.8 3.7 0.51 8.3 3.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 KOS20124.1 - 0.54 8.3 4.9 0.91 7.6 4.9 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SNN_transmemb PF09049.10 KOS20124.1 - 1.2 9.1 7.2 0.18 11.7 1.0 3.0 3 0 0 3 3 3 0 Stannin transmembrane 4_1_CTD PF05902.13 KOS20124.1 - 1.4 9.0 9.3 3.2 7.9 9.3 1.5 1 0 0 1 1 1 0 4.1 protein C-terminal domain (CTD) Mucin PF01456.17 KOS20124.1 - 1.6 8.7 18.8 0.081 12.9 13.2 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein MFS_1 PF07690.16 KOS20125.1 - 8.5e-28 97.3 26.8 8.5e-28 97.3 26.8 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Peptidase_M1 PF01433.20 KOS20126.1 - 8.6e-43 146.4 0.5 1.2e-42 146.0 0.5 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 KOS20126.1 - 2.3e-36 124.3 0.2 4.7e-36 123.3 0.2 1.5 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 KOS20126.1 - 5.4e-28 98.4 0.0 1e-27 97.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_M61 PF05299.12 KOS20126.1 - 0.56 10.6 2.8 9.7 6.6 2.8 2.5 1 1 0 1 1 1 0 M61 glycyl aminopeptidase DUF952 PF06108.12 KOS20127.1 - 1.3e-22 79.6 0.0 1.7e-22 79.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF952) Ten1 PF12658.7 KOS20128.1 - 5.6e-31 107.0 0.0 6.3e-31 106.9 0.0 1.0 1 0 0 1 1 1 1 Telomere capping, CST complex subunit Kinesin PF00225.23 KOS20129.1 - 1.4e-111 372.7 0.0 2.4e-111 371.9 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain DUF3694 PF12473.8 KOS20129.1 - 3.2e-49 167.5 1.1 7.6e-49 166.3 0.1 2.2 2 0 0 2 2 2 1 Kinesin protein Kinesin_assoc PF16183.5 KOS20129.1 - 8.2e-38 130.3 4.0 8.3e-31 107.5 0.1 3.7 3 0 0 3 3 3 2 Kinesin-associated Microtub_bd PF16796.5 KOS20129.1 - 5.5e-24 84.8 0.1 2e-23 83.0 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding KIF1B PF12423.8 KOS20129.1 - 4.3e-07 30.3 0.2 1.7e-06 28.4 0.2 2.1 1 0 0 1 1 1 1 Kinesin protein 1B PH PF00169.29 KOS20129.1 - 0.0096 16.4 0.0 2.9 8.4 0.0 2.8 2 0 0 2 2 2 1 PH domain Arm-DNA-bind_5 PF17293.2 KOS20129.1 - 0.52 10.8 3.6 0.3 11.6 0.3 2.4 2 0 0 2 2 2 0 Arm DNA-binding domain Exonuc_VII_L PF02601.15 KOS20129.1 - 0.9 9.1 8.5 3.5 7.1 8.0 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Methyltransf_23 PF13489.6 KOS20130.1 - 1e-09 38.5 0.0 1.4e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS20130.1 - 1.5e-06 28.8 0.0 6e-06 26.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS20130.1 - 2.6e-06 28.1 0.0 1.4e-05 25.7 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KOS20130.1 - 0.0039 17.3 0.0 0.0063 16.6 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 KOS20130.1 - 0.0051 16.6 0.0 1 9.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOS20130.1 - 0.036 14.7 0.0 0.11 13.1 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 KOS20130.1 - 0.046 13.0 0.0 0.11 11.8 0.0 1.8 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Peptidase_M48 PF01435.18 KOS20131.1 - 1.2e-37 129.6 0.1 7.8e-37 126.9 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M48 Spexin PF15171.6 KOS20131.1 - 0.033 14.4 0.0 14 5.9 0.0 2.9 3 0 0 3 3 3 0 Neuropeptide secretory protein family, NPQ, spexin RskA PF10099.9 KOS20131.1 - 0.087 13.1 2.5 0.16 12.2 2.5 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA SIS PF01380.22 KOS20132.1 - 1.9e-58 196.0 0.1 9.5e-32 109.6 0.1 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 KOS20132.1 - 8.9e-17 61.5 0.0 1.7e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOS20132.1 - 1.1e-10 41.4 0.0 2.7e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 KOS20132.1 - 5.2e-05 22.3 0.0 9e-05 21.5 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II AAA PF00004.29 KOS20133.1 - 6.9e-43 146.2 0.0 1.2e-42 145.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOS20133.1 - 1.5e-12 47.2 0.1 2.2e-11 43.5 0.1 2.3 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KOS20133.1 - 2.9e-11 43.0 0.1 6.3e-11 41.9 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOS20133.1 - 1.5e-07 32.0 0.0 6.7e-05 23.3 0.1 2.7 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 KOS20133.1 - 1.6e-06 28.2 0.1 3.8e-05 23.7 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOS20133.1 - 3.3e-06 27.3 0.0 9.2e-06 25.9 0.0 1.8 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 KOS20133.1 - 6.9e-06 25.9 0.0 1.5e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOS20133.1 - 0.00023 21.5 0.1 0.006 16.9 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS20133.1 - 0.00042 20.8 0.2 0.0023 18.5 0.0 2.4 3 1 0 3 3 2 1 AAA domain DUF815 PF05673.13 KOS20133.1 - 0.00043 19.5 0.0 0.00076 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 KOS20133.1 - 0.0011 18.5 0.0 0.0023 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region TIP49 PF06068.13 KOS20133.1 - 0.0022 17.3 0.0 0.0043 16.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 KOS20133.1 - 0.0033 17.4 0.1 0.0097 15.9 0.0 1.8 2 0 0 2 2 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 KOS20133.1 - 0.0036 16.7 0.0 0.0074 15.7 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 KOS20133.1 - 0.004 17.3 0.0 0.01 16.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain IstB_IS21 PF01695.17 KOS20133.1 - 0.005 16.6 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Prot_ATP_OB_N PF17758.1 KOS20133.1 - 0.0054 16.3 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain RNA_helicase PF00910.22 KOS20133.1 - 0.0058 17.0 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 KOS20133.1 - 0.0059 16.6 0.0 0.016 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 KOS20133.1 - 0.0087 15.8 0.0 0.027 14.2 0.0 1.9 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_11 PF13086.6 KOS20133.1 - 0.0094 15.8 0.7 0.26 11.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 KOS20133.1 - 0.011 15.7 0.0 0.03 14.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOS20133.1 - 0.02 14.6 0.0 0.057 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOS20133.1 - 0.042 13.2 0.8 0.13 11.5 0.0 2.2 3 0 0 3 3 3 0 KaiC PhoH PF02562.16 KOS20133.1 - 0.046 13.2 0.1 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 KOS20133.1 - 0.049 13.4 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS20133.1 - 0.057 13.3 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 KOS20133.1 - 0.086 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOS20133.1 - 0.099 12.2 0.0 0.22 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOS20133.1 - 0.1 11.9 0.0 0.26 10.5 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 KOS20133.1 - 0.12 12.8 1.6 17 5.9 1.6 2.4 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 KOS20133.1 - 0.13 11.3 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 eIF-1a PF01176.19 KOS20133.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 DivIC PF04977.15 KOS20133.1 - 0.45 10.3 2.8 4.9 7.0 1.0 2.7 2 0 0 2 2 2 0 Septum formation initiator DUF4200 PF13863.6 KOS20133.1 - 1.4 9.3 6.8 0.27 11.7 2.9 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4200) Mago-bind PF09282.10 KOS20134.1 - 1.3e-14 53.7 3.0 2.5e-14 52.8 3.0 1.5 1 0 0 1 1 1 1 Mago binding Dsh_C PF12316.8 KOS20134.1 - 0.0039 17.6 3.0 0.0051 17.2 3.0 1.2 1 0 0 1 1 1 1 Segment polarity protein dishevelled (Dsh) C terminal MCM_bind PF09739.9 KOS20134.1 - 0.014 13.9 4.9 0.014 13.9 4.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 KOS20134.1 - 0.078 11.7 10.6 0.093 11.5 10.6 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 KOS20134.1 - 0.16 12.1 4.7 0.2 11.8 4.7 1.3 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 KOS20134.1 - 0.19 11.5 15.2 0.23 11.2 15.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SAPS PF04499.15 KOS20134.1 - 0.51 9.1 11.4 0.65 8.7 11.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF5521 PF17659.1 KOS20134.1 - 0.57 8.0 6.4 0.68 7.7 6.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5521) FAM60A PF15396.6 KOS20134.1 - 0.64 10.0 9.0 0.87 9.6 9.0 1.4 1 0 0 1 1 1 0 Protein Family FAM60A CCDC53 PF10152.9 KOS20134.1 - 0.67 10.4 10.5 1.4 9.3 10.5 1.5 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Zip PF02535.22 KOS20134.1 - 1.2 8.3 4.5 1.3 8.2 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 KOS20134.1 - 1.4 5.9 6.1 1.5 5.8 6.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 KOS20134.1 - 2 8.4 8.2 2.4 8.1 8.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 KOS20134.1 - 2.1 7.7 11.8 2.3 7.5 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hid1 PF12722.7 KOS20134.1 - 2.3 6.2 10.7 2.6 6.0 10.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Gti1_Pac2 PF09729.9 KOS20134.1 - 2.6 8.1 9.6 3.6 7.6 9.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 KOS20134.1 - 2.9 6.8 11.7 3.6 6.5 11.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Paramyxo_ncap PF00973.19 KOS20134.1 - 4.6 6.1 9.5 5.7 5.7 9.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CDC45 PF02724.14 KOS20134.1 - 5.6 5.1 14.8 6.9 4.8 14.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Cation_ATPase_C PF00689.21 KOS20135.1 - 1.1e-47 162.1 1.4 1.1e-47 162.1 1.4 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOS20135.1 - 1.6e-36 125.5 0.5 1.6e-36 125.5 0.5 2.3 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOS20135.1 - 7e-23 80.5 0.0 2e-22 79.1 0.0 1.8 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOS20135.1 - 1.5e-16 61.3 0.3 9.6e-16 58.7 0.3 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOS20135.1 - 1.7e-09 37.2 0.2 6.6e-09 35.3 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS20135.1 - 0.0013 18.6 0.2 0.0025 17.6 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RskA PF10099.9 KOS20135.1 - 0.17 12.2 0.5 1.7 8.9 0.1 2.7 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF996 PF06195.13 KOS20135.1 - 4.1 7.7 11.4 1.7 9.0 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF996) zf-UBR PF02207.20 KOS20136.1 - 4.1e-17 62.1 17.4 1.1e-16 60.7 17.4 1.8 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 KOS20136.1 - 3.2e-06 26.8 0.0 7.4e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS CRC_subunit PF08624.10 KOS20137.1 - 1e-53 181.4 0.0 1.9e-53 180.5 0.0 1.5 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Cyclin PF08613.11 KOS20138.1 - 3.4e-10 40.5 0.0 6.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOS20138.1 - 0.017 14.8 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Cyclin, N-terminal domain Nefa_Nip30_N PF10187.9 KOS20139.1 - 7.4e-29 100.2 11.8 7.4e-29 100.2 11.8 3.1 2 2 1 3 3 3 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Caldesmon PF02029.15 KOS20139.1 - 1.3 7.7 40.6 1.6 7.4 40.6 1.1 1 0 0 1 1 1 0 Caldesmon Protocadherin PF08374.11 KOS20139.1 - 6.3 6.7 7.7 3.4 7.6 5.0 1.8 2 0 0 2 2 2 0 Protocadherin Tim54 PF11711.8 KOS20140.1 - 7.2e-141 469.3 0.0 8.3e-141 469.1 0.0 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 ARS2 PF04959.13 KOS20140.1 - 0.34 11.3 3.7 1.7 8.9 0.0 2.4 2 0 0 2 2 2 0 Arsenite-resistance protein 2 Pkinase PF00069.25 KOS20141.1 - 5.1e-57 193.2 0.0 6.1e-56 189.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20141.1 - 1.8e-26 93.0 0.2 3.7e-20 72.3 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 KOS20141.1 - 0.0001 22.3 0.4 0.02 14.8 0.5 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 KOS20141.1 - 0.00011 21.3 0.0 0.00016 20.8 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS20141.1 - 0.00063 19.1 0.0 0.0015 17.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS20141.1 - 0.0009 18.6 0.6 0.002 17.5 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 KOS20141.1 - 0.091 11.8 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 KOS20141.1 - 0.25 10.9 1.9 0.87 9.1 0.0 2.1 2 0 0 2 2 2 0 RIO1 family Vta1 PF04652.16 KOS20142.1 - 1.5e-50 171.0 2.2 7.1e-50 168.8 1.4 1.9 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 KOS20142.1 - 4.3e-18 64.7 0.1 1e-17 63.5 0.1 1.7 1 0 0 1 1 1 1 Vta1 C-terminal domain OPT PF03169.15 KOS20143.1 - 1.2e-165 552.6 48.7 1.4e-165 552.4 48.7 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein SAPS PF04499.15 KOS20144.1 - 6.7e-36 124.1 0.1 1.8e-35 122.7 0.0 1.6 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein CENP-B_dimeris PF09026.10 KOS20144.1 - 0.53 10.7 5.7 0.99 9.8 5.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain SAPS PF04499.15 KOS20146.1 - 9.7e-114 380.8 0.0 3.2e-113 379.1 0.0 1.7 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein HEAT_2 PF13646.6 KOS20147.1 - 3.1e-05 24.3 1.1 0.26 11.7 0.1 4.2 2 2 2 4 4 4 1 HEAT repeats HEAT PF02985.22 KOS20147.1 - 8e-05 22.6 1.6 2.4 8.6 0.1 4.8 5 0 0 5 5 3 1 HEAT repeat CLASP_N PF12348.8 KOS20147.1 - 0.00071 19.2 0.0 0.014 15.0 0.0 2.6 3 0 0 3 3 3 1 CLASP N terminal Cnd1 PF12717.7 KOS20147.1 - 0.0015 18.6 0.0 0.0055 16.8 0.0 1.9 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TAN PF11640.8 KOS20147.1 - 0.0092 16.1 0.0 0.025 14.7 0.0 1.8 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair ACT_6 PF13740.6 KOS20147.1 - 0.013 15.4 0.0 4.2 7.4 0.0 2.7 2 0 0 2 2 2 0 ACT domain APG6_N PF17675.1 KOS20147.1 - 0.019 15.5 2.1 0.019 15.5 2.1 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region CCDC144C PF14915.6 KOS20147.1 - 0.031 13.4 5.1 0.061 12.4 5.1 1.4 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Spc7 PF08317.11 KOS20147.1 - 0.11 11.3 4.2 0.29 10.0 4.2 1.6 1 0 0 1 1 1 0 Spc7 kinetochore protein HALZ PF02183.18 KOS20147.1 - 0.12 12.6 3.1 0.13 12.5 1.4 2.0 2 0 0 2 2 1 0 Homeobox associated leucine zipper TolA_bind_tri PF16331.5 KOS20147.1 - 0.13 12.3 2.7 0.4 10.8 2.7 1.8 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF4763 PF15960.5 KOS20147.1 - 0.28 10.5 2.5 0.17 11.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) SHE3 PF17078.5 KOS20147.1 - 0.38 10.4 3.0 0.75 9.5 3.0 1.4 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF1640 PF07798.11 KOS20147.1 - 0.62 10.1 8.3 0.15 12.1 4.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) Mto2_bdg PF12808.7 KOS20147.1 - 2.1 8.7 6.2 3.1 8.2 3.3 2.8 1 1 1 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Jnk-SapK_ap_N PF09744.9 KOS20147.1 - 2.4 8.4 11.2 0.14 12.4 5.4 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 KOS20147.1 - 2.6 7.4 8.4 9.3 5.6 8.4 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 MCC-bdg_PDZ PF10506.9 KOS20147.1 - 8 6.6 8.1 3.8 7.6 1.5 3.1 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome GrpE PF01025.19 KOS20147.1 - 8.8 6.0 8.5 37 3.9 0.3 3.2 3 0 0 3 3 3 0 GrpE SHR-BD PF06650.12 KOS20148.1 - 3.4e-95 318.5 0.0 1.3e-94 316.6 0.0 2.0 2 1 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_C PF16909.5 KOS20148.1 - 6.9e-75 250.7 7.9 4.1e-70 235.2 1.5 2.4 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 KOS20148.1 - 1.1e-06 28.9 0.0 6.5e-06 26.4 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain DUF3425 PF11905.8 KOS20148.1 - 0.0059 16.6 0.1 0.6 10.1 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3425) VPS13_mid_rpt PF16910.5 KOS20149.1 - 7.9e-89 297.1 13.9 1.8e-87 292.7 0.5 5.2 6 0 0 6 6 6 2 Repeating coiled region of VPS13 VPS13 PF16908.5 KOS20149.1 - 5.1e-80 268.7 6.2 4.2e-79 265.7 0.0 3.9 4 0 0 4 4 4 1 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 KOS20149.1 - 1.9e-41 140.8 0.0 8.3e-41 138.8 0.0 2.2 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 M_domain PF12938.7 KOS20149.1 - 0.91 9.3 7.8 2.2 8.0 7.8 1.6 1 0 0 1 1 1 0 M domain of GW182 DUF647 PF04884.14 KOS20150.1 - 2.1e-79 266.6 1.3 2.4e-79 266.4 1.3 1.0 1 0 0 1 1 1 1 Vitamin B6 photo-protection and homoeostasis FtsK_4TM PF13491.6 KOS20150.1 - 0.0014 18.3 1.5 0.0032 17.2 1.5 1.6 1 0 0 1 1 1 1 4TM region of DNA translocase FtsK/SpoIIIE DUF3761 PF12587.8 KOS20150.1 - 0.086 13.3 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) MDD_C PF18376.1 KOS20151.1 - 2.9e-66 222.8 0.0 3.8e-66 222.4 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 KOS20151.1 - 2.2e-08 34.2 1.4 5.8e-08 32.8 1.4 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain Acetyltransf_8 PF13523.6 KOS20152.1 - 8.7e-29 100.1 0.0 2.3e-28 98.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain YL1 PF05764.13 KOS20152.1 - 0.00038 20.6 0.2 0.00052 20.2 0.2 1.1 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 KOS20152.1 - 0.002 16.5 0.7 0.0026 16.1 0.7 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF3499 PF12005.8 KOS20152.1 - 0.013 16.0 0.6 0.023 15.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) BUD22 PF09073.10 KOS20152.1 - 0.033 13.6 3.3 0.046 13.1 3.3 1.1 1 0 0 1 1 1 0 BUD22 Sigma70_ner PF04546.13 KOS20152.1 - 1.4 8.7 5.4 2 8.2 5.4 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region XAP5 PF04921.14 KOS20152.1 - 1.8 8.3 4.4 2.9 7.7 4.4 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator Cyto_heme_lyase PF01265.17 KOS20153.1 - 1e-32 113.9 2.2 5.2e-32 111.6 2.2 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase A_deaminase PF00962.22 KOS20154.1 - 2.3e-24 86.3 0.0 1.2e-23 84.0 0.0 2.0 1 1 0 1 1 1 1 Adenosine/AMP deaminase Acyl-CoA_dh_1 PF00441.24 KOS20155.1 - 2.1e-14 54.0 0.1 1.2e-12 48.3 0.1 2.7 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AidB_N PF18158.1 KOS20155.1 - 1.2e-11 44.7 0.0 2e-11 44.1 0.0 1.3 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain Acyl-CoA_dh_M PF02770.19 KOS20155.1 - 6.3e-09 35.9 0.0 1.7e-08 34.5 0.0 1.8 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Hydantoinase_B PF02538.14 KOS20156.1 - 1.1e-218 726.9 0.0 1.5e-218 726.4 0.0 1.2 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 KOS20156.1 - 1.9e-102 342.5 0.7 3.8e-102 341.5 0.7 1.5 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 KOS20156.1 - 1.5e-61 207.2 1.3 7.4e-60 201.7 0.0 2.5 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region NAD_binding_10 PF13460.6 KOS20157.1 - 2.5e-06 27.5 0.0 4.6e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOS20157.1 - 0.00013 21.7 0.2 0.0011 18.6 0.0 2.2 2 0 0 2 2 2 1 NmrA-like family Sacchrp_dh_NADP PF03435.18 KOS20157.1 - 0.039 14.2 0.0 0.065 13.5 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain MARVEL PF01284.23 KOS20158.1 - 1.3e-16 60.9 9.6 1.7e-16 60.6 9.6 1.0 1 0 0 1 1 1 1 Membrane-associating domain APG5 PF04106.12 KOS20160.1 - 3.9e-42 144.4 0.0 1.4e-41 142.6 0.0 1.7 1 1 0 1 1 1 1 Autophagy protein Apg5 Presenilin PF01080.17 KOS20161.1 - 5.7 5.6 4.8 7.3 5.2 4.8 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KOS20162.1 - 0.022 13.1 5.9 0.03 12.6 5.9 1.1 1 0 0 1 1 1 0 CDC45-like protein GP67 PF17634.2 KOS20162.1 - 0.023 15.1 10.5 0.034 14.5 10.5 1.3 1 0 0 1 1 1 0 Gene product 67 Nop14 PF04147.12 KOS20162.1 - 0.17 10.1 5.2 0.21 9.8 5.2 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 KOS20162.1 - 0.4 9.2 1.1 0.46 9.0 1.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 KOS20162.1 - 0.42 10.7 11.3 0.059 13.5 7.1 1.6 2 0 0 2 2 2 0 YL1 nuclear protein DUF4637 PF15470.6 KOS20162.1 - 0.92 9.2 5.7 1.6 8.4 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TFB6 PF17110.5 KOS20162.1 - 0.99 9.1 2.9 1.8 8.3 2.9 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CENP-B_dimeris PF09026.10 KOS20162.1 - 1.2 9.6 13.8 2.2 8.7 13.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Paf1 PF03985.13 KOS20162.1 - 1.4 7.8 6.3 2.1 7.3 6.3 1.1 1 0 0 1 1 1 0 Paf1 FAM176 PF14851.6 KOS20162.1 - 1.6 8.4 6.5 2.7 7.7 6.5 1.3 1 0 0 1 1 1 0 FAM176 family PPP4R2 PF09184.11 KOS20162.1 - 2.3 7.7 7.6 3.1 7.3 7.6 1.1 1 0 0 1 1 1 0 PPP4R2 NOA36 PF06524.12 KOS20162.1 - 2.7 7.2 13.7 3.7 6.8 13.7 1.1 1 0 0 1 1 1 0 NOA36 protein GCIP PF13324.6 KOS20162.1 - 3.5 7.2 4.0 4.5 6.8 4.0 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DNA_pol_phi PF04931.13 KOS20162.1 - 3.7 5.5 13.4 4.8 5.2 13.4 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 KOS20162.1 - 6.4 5.8 18.9 0.14 11.3 12.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 KOS20162.1 - 8.8 6.1 7.0 15 5.4 7.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein WD40 PF00400.32 KOS20163.1 - 2.7e-21 75.5 14.6 0.0002 22.1 0.1 6.3 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20163.1 - 1.6e-11 44.3 0.1 0.0085 16.4 0.0 4.9 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS20163.1 - 0.28 11.1 0.0 21 4.9 0.0 2.6 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A UQ_con PF00179.26 KOS20164.1 - 3.7e-49 166.0 0.0 4.2e-49 165.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS20164.1 - 2e-05 24.3 0.0 2.3e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOS20164.1 - 0.016 15.5 0.6 0.039 14.2 0.6 1.8 1 1 0 1 1 1 0 RWD domain MerR-DNA-bind PF09278.11 KOS20164.1 - 0.056 14.0 0.0 0.098 13.2 0.0 1.3 1 0 0 1 1 1 0 MerR, DNA binding Asn_synthase PF00733.21 KOS20165.1 - 1e-90 305.0 0.1 4.9e-53 181.1 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 KOS20165.1 - 2.9e-36 124.1 0.0 4.7e-36 123.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 KOS20165.1 - 8.2e-28 97.3 0.0 1.4e-27 96.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 KOS20165.1 - 4.1e-07 29.7 0.0 6.9e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 KOS20165.1 - 0.0011 18.2 0.0 0.0042 16.2 0.0 1.8 2 0 0 2 2 2 1 NAD synthase DUF836 PF05768.14 KOS20166.1 - 4.3e-12 46.3 0.0 5e-12 46.1 0.0 1.1 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 KOS20166.1 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.5 1 0 0 1 1 1 1 Glutaredoxin HpcH_HpaI PF03328.14 KOS20167.1 - 7.9e-27 93.8 0.0 1e-22 80.4 0.0 2.1 1 1 1 2 2 2 2 HpcH/HpaI aldolase/citrate lyase family SHS2_Rpb7-N PF03876.17 KOS20168.1 - 3.3e-15 56.2 0.0 5.2e-15 55.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 KOS20168.1 - 2.5e-13 50.1 0.0 3.8e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain DUF962 PF06127.11 KOS20169.1 - 7.2e-17 61.3 0.0 1.2e-16 60.6 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) Porin_3 PF01459.22 KOS20170.1 - 2.8e-69 233.6 4.6 3.2e-69 233.4 4.6 1.0 1 0 0 1 1 1 1 Eukaryotic porin DnaJ PF00226.31 KOS20171.1 - 7.7e-18 64.4 0.1 7.7e-18 64.4 0.1 1.9 2 0 0 2 2 2 1 DnaJ domain Glyco_hydro_47 PF01532.20 KOS20172.1 - 3.3e-162 540.6 0.0 3.8e-162 540.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 CHORD PF04968.12 KOS20173.1 - 3.9e-50 168.4 16.3 1.1e-25 90.1 6.3 2.3 2 0 0 2 2 2 2 CHORD CS PF04969.16 KOS20173.1 - 2e-11 44.7 0.1 3.6e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 CS domain UTP25 PF06862.12 KOS20174.1 - 1.4e-193 644.0 0.0 1.8e-193 643.7 0.0 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 KOS20174.1 - 0.0029 17.4 0.0 0.1 12.3 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase MitMem_reg PF13012.6 KOS20175.1 - 6.1e-19 68.5 0.3 1.4e-18 67.4 0.1 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KOS20175.1 - 4.5e-18 65.3 0.0 7.9e-18 64.6 0.0 1.3 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease SUZ PF12752.7 KOS20176.1 - 2.1e-08 34.8 0.2 2.1e-08 34.8 0.2 2.7 3 0 0 3 3 3 1 SUZ domain zf-CCHC_3 PF13917.6 KOS20177.1 - 3.7e-11 42.8 2.1 5.7e-11 42.2 2.1 1.3 1 0 0 1 1 1 1 Zinc knuckle cwf18 PF08315.12 KOS20178.1 - 7.1e-44 149.8 3.2 7.1e-44 149.8 3.2 2.2 2 1 0 2 2 2 1 cwf18 pre-mRNA splicing factor FSA_C PF10479.9 KOS20178.1 - 0.18 9.9 7.1 0.24 9.5 7.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 KOS20178.1 - 0.69 9.9 18.9 1.8 8.5 18.9 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 KOS20178.1 - 2.9 7.9 11.3 4.5 7.3 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) RR_TM4-6 PF06459.12 KOS20178.1 - 3 7.6 7.3 4.9 6.9 7.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPR_2 PF13041.6 KOS20179.1 - 3.8e-14 52.6 0.0 1.6e-05 25.0 0.0 5.7 5 1 1 6 6 6 3 PPR repeat family PPR_1 PF12854.7 KOS20179.1 - 1.1e-08 34.6 0.0 0.028 14.1 0.0 4.5 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 KOS20179.1 - 2.1e-08 34.1 0.0 2.5e-05 24.3 0.0 3.6 3 0 0 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 KOS20179.1 - 1.2e-06 28.3 0.0 0.41 11.0 0.0 4.9 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 KOS20179.1 - 6e-06 25.8 0.0 0.0003 20.2 0.0 2.5 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP SUIM_assoc PF16619.5 KOS20179.1 - 0.03 14.4 0.2 0.062 13.4 0.2 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Citrate_synt PF00285.21 KOS20179.1 - 0.093 11.8 0.1 1.1 8.2 0.0 2.2 2 0 0 2 2 2 0 Citrate synthase, C-terminal domain Hexapep_2 PF14602.6 KOS20180.1 - 4.1e-13 48.8 19.8 2.9e-07 30.1 3.9 2.3 2 0 0 2 2 2 2 Hexapeptide repeat of succinyl-transferase Hexapep PF00132.24 KOS20180.1 - 8.4e-12 44.3 17.8 7.1e-06 25.5 3.3 3.4 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Mac PF12464.8 KOS20180.1 - 1e-09 38.5 0.0 3.6e-09 36.7 0.0 2.0 1 0 0 1 1 1 1 Maltose acetyltransferase Zn_clus PF00172.18 KOS20180.1 - 0.0053 16.9 5.8 0.012 15.7 5.8 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF1707 PF08044.11 KOS20180.1 - 0.091 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) Acetyltransf_11 PF13720.6 KOS20180.1 - 0.11 13.0 0.1 0.21 12.1 0.1 1.5 1 0 0 1 1 1 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 GREB1 PF15782.5 KOS20180.1 - 8.4 3.4 15.5 10 3.1 15.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SANT_DAMP1_like PF16282.5 KOS20181.1 - 6.6e-32 109.5 0.4 1.2e-31 108.7 0.4 1.4 1 0 0 1 1 1 1 SANT/Myb-like domain of DAMP1 Med3 PF11593.8 KOS20181.1 - 0.00042 19.6 20.5 0.00042 19.6 20.5 3.0 2 1 0 2 2 2 1 Mediator complex subunit 3 fungal DUF572 PF04502.13 KOS20181.1 - 2.4 7.7 41.1 1.6 8.3 16.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) DUF2457 PF10446.9 KOS20181.1 - 2.9 7.0 44.4 0.045 12.9 21.8 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2457) SR-25 PF10500.9 KOS20181.1 - 9.5 5.8 32.8 2.2 7.8 17.3 3.2 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein EMP24_GP25L PF01105.24 KOS20182.1 - 3.3e-51 173.8 0.0 3.7e-51 173.6 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Pkinase PF00069.25 KOS20183.1 - 2e-27 96.2 0.0 2.9e-27 95.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20183.1 - 1.7e-14 53.7 0.0 2.3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS20183.1 - 3.6e-07 29.3 0.1 4.9e-07 28.9 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Peptidase_M44 PF03410.13 KOS20183.1 - 0.14 10.7 0.0 0.2 10.2 0.0 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox F-box-like PF12937.7 KOS20184.1 - 0.075 12.9 0.1 0.23 11.4 0.1 1.9 1 1 0 1 1 1 0 F-box-like GST_C PF00043.25 KOS20184.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain UQ_con PF00179.26 KOS20185.1 - 1.2e-35 122.2 0.1 1.7e-21 76.3 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS20185.1 - 0.00038 20.2 0.0 0.073 12.8 0.0 2.3 2 0 0 2 2 2 2 Prokaryotic E2 family B HMG_box PF00505.19 KOS20187.1 - 1.1e-09 38.6 1.8 2.9e-08 34.0 0.1 4.5 3 3 1 4 4 4 2 HMG (high mobility group) box HMG_box_2 PF09011.10 KOS20187.1 - 2.9e-05 24.6 5.4 9.6e-05 22.9 1.4 3.4 3 1 0 3 3 3 2 HMG-box domain Ndc1_Nup PF09531.10 KOS20187.1 - 0.32 9.6 3.7 0.43 9.2 3.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup YABBY PF04690.13 KOS20187.1 - 0.52 10.9 9.1 5 7.7 4.8 2.3 2 0 0 2 2 2 0 YABBY protein Med3 PF11593.8 KOS20187.1 - 1.7 7.7 10.0 2.9 7.0 10.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Proteasome PF00227.26 KOS20188.1 - 7.8e-32 110.3 0.0 9.5e-32 110.0 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit 3Beta_HSD PF01073.19 KOS20189.1 - 3.2e-66 223.2 0.0 4.1e-66 222.8 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 KOS20189.1 - 3.2e-32 111.9 0.1 5.3e-32 111.2 0.1 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOS20189.1 - 5.3e-15 55.3 0.0 9.4e-15 54.5 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KOS20189.1 - 1.5e-14 54.2 0.0 8.7e-13 48.4 0.0 2.2 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 KOS20189.1 - 2.8e-13 49.7 0.0 4.4e-11 42.5 0.0 2.1 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 KOS20189.1 - 2.7e-07 30.7 0.0 4.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 KOS20189.1 - 2.1e-06 27.1 0.5 1e-05 24.8 0.5 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 KOS20189.1 - 0.014 15.3 0.5 0.12 12.3 0.5 2.1 1 1 0 1 1 1 0 KR domain Glyco_transf_4 PF13439.6 KOS20189.1 - 0.023 14.7 2.3 0.15 12.0 0.0 2.7 3 0 0 3 3 3 0 Glycosyltransferase Family 4 eIF-5_eIF-2B PF01873.17 KOS20190.1 - 6.6e-42 142.1 0.7 1e-41 141.5 0.7 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 KOS20190.1 - 0.069 12.7 0.8 0.14 11.7 0.8 1.6 1 0 0 1 1 1 0 TFIIB zinc-binding zf-HYPF PF07503.12 KOS20190.1 - 0.84 9.5 4.2 5.6 6.8 4.5 2.2 1 1 1 2 2 2 0 HypF finger Arc_trans_TRASH PF08394.10 KOS20190.1 - 0.99 9.8 8.2 1.1 9.6 0.4 2.5 1 1 1 2 2 2 0 Archaeal TRASH domain DUF4536 PF15055.6 KOS20192.1 - 0.00054 20.1 4.8 0.00098 19.3 4.8 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4536) Adap_comp_sub PF00928.21 KOS20193.1 - 5.5e-66 222.6 0.0 8.7e-66 222.0 0.0 1.3 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOS20193.1 - 0.0022 17.9 0.1 0.0037 17.2 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Aldedh PF00171.22 KOS20194.1 - 4.8e-75 252.8 0.0 5.6e-75 252.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ECR1_N PF14382.6 KOS20195.1 - 7.3e-13 48.1 0.5 1.3e-12 47.3 0.5 1.4 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 KOS20195.1 - 0.00023 21.4 0.0 0.00049 20.4 0.0 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 KOS20195.1 - 0.067 13.8 0.2 0.43 11.2 0.2 2.2 1 1 1 2 2 2 0 Exosome component EXOSC1/CSL4 p47_phox_C PF08944.11 KOS20195.1 - 0.13 11.7 2.1 0.27 10.7 2.1 1.5 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain AFG1_ATPase PF03969.16 KOS20196.1 - 4.3e-48 164.0 0.0 9.2e-24 84.0 0.0 4.4 5 0 0 5 5 5 3 AFG1-like ATPase AAA_16 PF13191.6 KOS20196.1 - 1.8e-08 34.9 0.8 6.6e-08 33.1 0.5 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOS20196.1 - 0.00032 21.0 0.0 0.0006 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS20196.1 - 0.00044 20.2 0.0 0.00085 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 KOS20196.1 - 0.0037 17.2 0.0 0.0083 16.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 KOS20196.1 - 0.03 14.9 0.0 0.47 11.0 0.0 2.1 1 1 1 2 2 2 0 ABC transporter Bac_DnaA PF00308.18 KOS20196.1 - 0.059 13.2 0.0 6.6 6.5 0.0 2.9 3 0 0 3 3 3 0 Bacterial dnaA protein AAA PF00004.29 KOS20196.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 KOS20196.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PIF1 PF05970.14 KOS20196.1 - 0.24 10.6 0.0 0.34 10.0 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase DUF3446 PF11928.8 KOS20196.1 - 9.3 6.6 18.4 2.1 8.7 0.8 3.0 3 0 0 3 3 3 0 Early growth response N-terminal domain Nucleoporin_C PF03177.14 KOS20197.1 - 5.2e-166 553.9 4.7 7e-166 553.5 4.7 1.2 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nucleoporin_N PF08801.11 KOS20197.1 - 1.9e-79 267.5 0.0 2.4e-79 267.1 0.0 1.1 1 0 0 1 1 1 1 Nup133 N terminal like DUF4129 PF13559.6 KOS20197.1 - 0.02 15.2 0.1 0.094 13.0 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Alfin PF12165.8 KOS20197.1 - 0.044 13.4 0.0 0.73 9.5 0.0 2.4 2 0 0 2 2 2 0 Alfin Acyl_transf_1 PF00698.21 KOS20198.1 - 4.4e-19 69.1 0.1 1.1e-13 51.4 0.4 2.1 1 1 1 2 2 2 2 Acyl transferase domain Sedlin_N PF04628.13 KOS20199.1 - 9.9e-11 41.9 0.0 1.3e-10 41.5 0.0 1.1 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF3446 PF11928.8 KOS20199.1 - 0.0019 18.5 0.2 2.2 8.7 0.0 2.1 2 0 0 2 2 2 2 Early growth response N-terminal domain SUR7 PF06687.12 KOS20201.1 - 7.7e-24 84.5 16.0 1e-23 84.1 16.0 1.1 1 0 0 1 1 1 1 SUR7/PalI family DUF3433 PF11915.8 KOS20203.1 - 5.2e-39 132.6 16.7 4.9e-22 78.2 1.2 3.8 4 0 0 4 4 4 2 Protein of unknown function (DUF3433) UPF0370 PF13980.6 KOS20203.1 - 2.7 8.1 5.3 9.2 6.4 5.3 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) DUF2065 PF09838.9 KOS20203.1 - 6 7.0 7.1 0.77 9.8 0.3 2.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2065) TRP PF06011.12 KOS20204.1 - 6.1e-158 526.0 31.2 7.4e-158 525.7 31.2 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOS20204.1 - 3.2e-41 140.9 1.1 5.6e-41 140.2 1.1 1.4 1 0 0 1 1 1 1 ML-like domain E1_DerP2_DerF2 PF02221.15 KOS20204.1 - 0.049 14.1 0.1 0.082 13.3 0.1 1.3 1 0 0 1 1 1 0 ML domain AIM24 PF01987.17 KOS20205.1 - 7.9e-54 182.5 0.1 1e-53 182.2 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 zf-C2H2_jaz PF12171.8 KOS20206.1 - 0.0082 16.4 1.3 0.0082 16.4 1.3 2.8 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 KOS20206.1 - 0.0088 16.5 10.4 3.3 8.4 0.4 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS20206.1 - 0.055 14.3 15.3 0.27 12.2 0.5 4.4 4 0 0 4 4 4 0 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 KOS20206.1 - 0.13 13.0 2.7 3.4 8.4 1.9 2.5 2 1 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-TRAF PF02176.18 KOS20206.1 - 0.3 11.8 5.1 0.24 12.1 2.7 2.0 2 0 0 2 2 2 0 TRAF-type zinc finger zf-C2H2_6 PF13912.6 KOS20207.1 - 0.00042 20.2 9.3 0.025 14.6 2.7 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 KOS20207.1 - 0.014 15.8 4.2 0.014 15.8 4.2 5.8 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 KOS20207.1 - 0.017 15.4 0.5 0.017 15.4 0.5 3.8 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 KOS20207.1 - 0.037 14.9 3.4 0.037 14.9 3.4 6.5 7 0 0 7 7 7 0 C2H2-type zinc finger FOXP-CC PF16159.5 KOS20207.1 - 2.4 8.8 15.0 0.086 13.5 1.5 4.0 2 1 2 4 4 4 0 FOXP coiled-coil domain Cyt-b5 PF00173.28 KOS20208.1 - 3.5e-06 27.1 0.1 4.3e-06 26.8 0.1 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Myb_DNA-bind_4 PF13837.6 KOS20210.1 - 0.0042 17.4 0.1 0.01 16.2 0.1 1.6 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain TPR_2 PF07719.17 KOS20210.1 - 0.44 10.8 2.5 0.48 10.7 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat SIS PF01380.22 KOS20211.1 - 3.6e-14 52.7 0.0 3.6e-13 49.5 0.0 2.4 2 1 0 2 2 2 1 SIS domain Ceramidase_alk PF04734.13 KOS20212.1 - 1.5e-184 614.4 0.0 1.9e-184 614.1 0.0 1.0 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, N-terminal Ceramidse_alk_C PF17048.5 KOS20212.1 - 4.1e-57 192.7 0.0 6.6e-57 192.0 0.0 1.3 1 0 0 1 1 1 1 Neutral/alkaline non-lysosomal ceramidase, C-terminal Peptidase_S10 PF00450.22 KOS20213.1 - 3.2e-113 379.3 0.0 3.9e-113 379.0 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase SPX PF03105.19 KOS20215.1 - 1.4e-10 41.7 1.8 2.4e-05 24.4 0.0 3.0 2 1 1 3 3 3 2 SPX domain bZIP_1 PF00170.21 KOS20216.1 - 1.9e-12 47.1 7.9 2.5e-12 46.7 7.9 1.1 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOS20216.1 - 1.4e-07 31.5 8.4 2.2e-07 30.8 8.4 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 KOS20216.1 - 0.00032 21.1 5.5 0.00048 20.6 5.5 1.2 1 0 0 1 1 1 1 bZIP Maf transcription factor K1377 PF15352.6 KOS20216.1 - 0.0014 17.0 0.9 0.0017 16.7 0.9 1.0 1 0 0 1 1 1 1 Susceptibility to monomelic amyotrophy GST_N_3 PF13417.6 KOS20217.1 - 1.5e-08 35.0 0.2 2.7e-08 34.1 0.2 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOS20217.1 - 3.1e-06 27.1 0.1 6.9e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOS20217.1 - 0.00049 20.3 0.2 0.0012 19.1 0.2 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain zf-CCHC PF00098.23 KOS20218.1 - 3.3e-49 162.9 95.4 9.2e-07 28.7 2.3 10.5 11 0 0 11 11 11 10 Zinc knuckle zf-CCHC_2 PF13696.6 KOS20218.1 - 7e-16 57.7 83.9 0.00013 21.7 1.8 10.2 11 0 0 11 11 11 7 Zinc knuckle zf-CCHC_4 PF14392.6 KOS20218.1 - 4.5e-08 32.7 61.6 0.21 11.4 0.2 10.3 9 1 1 10 10 10 8 Zinc knuckle zf-CCHC_3 PF13917.6 KOS20218.1 - 6.9e-07 29.1 78.1 0.035 14.1 0.5 10.1 2 2 8 10 10 10 8 Zinc knuckle zf-C2H2_10 PF16588.5 KOS20218.1 - 0.00022 20.9 4.5 0.00066 19.4 0.9 9.4 10 0 0 10 10 10 5 C2H2 zinc-finger zf-CCHC_6 PF15288.6 KOS20218.1 - 0.11 12.4 76.8 0.43 10.5 0.3 10.2 7 2 3 10 10 10 0 Zinc knuckle CIAPIN1 PF05093.13 KOS20219.1 - 9.6e-42 141.6 2.6 1.6e-41 140.9 2.6 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 KOS20219.1 - 2.6e-33 115.1 0.0 3.8e-33 114.5 0.0 1.3 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus LIM PF00412.22 KOS20220.1 - 1.5e-18 66.7 9.7 3.5e-09 36.8 1.0 2.1 2 0 0 2 2 2 2 LIM domain WRC PF08879.10 KOS20220.1 - 0.0096 15.6 0.2 0.019 14.6 0.2 1.4 1 0 0 1 1 1 1 WRC Lar_restr_allev PF14354.6 KOS20220.1 - 0.36 11.2 7.6 0.42 11.0 1.7 2.2 2 0 0 2 2 2 0 Restriction alleviation protein Lar Nop14 PF04147.12 KOS20221.1 - 1.4 7.1 7.1 1.4 7.0 7.1 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOS20221.1 - 1.9 7.8 6.8 2.7 7.2 6.8 1.2 1 0 0 1 1 1 0 NOA36 protein AMPK1_CBM PF16561.5 KOS20222.1 - 0.00062 19.9 0.0 0.0012 19.0 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase Amidohydro_2 PF04909.14 KOS20223.1 - 9.8e-21 74.8 2.7 2.7e-20 73.3 2.7 1.7 1 1 0 1 1 1 1 Amidohydrolase HD PF01966.22 KOS20224.1 - 6.6e-07 29.6 0.9 6.7e-06 26.3 0.2 2.1 2 0 0 2 2 2 1 HD domain LSM PF01423.22 KOS20225.1 - 8.5e-21 73.4 0.1 9.7e-21 73.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Aldedh PF00171.22 KOS20226.1 - 6.7e-15 54.6 11.5 5.3e-09 35.1 7.0 2.6 1 1 1 2 2 2 2 Aldehyde dehydrogenase family PALP PF00291.25 KOS20229.1 - 6.1e-63 213.0 0.8 7.6e-63 212.6 0.8 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF3343 PF11823.8 KOS20229.1 - 0.085 12.3 0.0 0.26 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3343) HRDC PF00570.23 KOS20229.1 - 0.16 12.0 0.0 4 7.5 0.0 2.7 2 0 0 2 2 2 0 HRDC domain Fungal_TACC PF12709.7 KOS20230.1 - 7.9e-10 39.0 22.9 1.3e-09 38.3 0.5 4.5 3 1 2 5 5 5 2 Fungal Transforming acidic coiled-coil (TACC) proteins SKA1 PF07160.12 KOS20230.1 - 1.9 8.3 27.4 1.4 8.7 7.2 3.3 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 CENP-F_leu_zip PF10473.9 KOS20230.1 - 9 6.3 41.7 0.14 12.2 3.9 3.9 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KilA-N PF04383.13 KOS20231.1 - 0.0014 18.5 0.0 0.044 13.6 0.0 2.4 1 1 0 1 1 1 1 KilA-N domain FAD_binding_4 PF01565.23 KOS20232.1 - 4.6e-34 117.1 5.5 9.6e-34 116.1 5.5 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS20232.1 - 3.2e-09 36.7 0.1 6.1e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 Berberine and berberine like Cytokin-bind PF09265.10 KOS20232.1 - 0.0071 15.8 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF5363 PF17320.2 KOS20232.1 - 0.009 15.9 0.2 0.02 14.7 0.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5363) Glyco_hydro_30C PF17189.4 KOS20233.1 - 4.5e-08 33.2 0.3 8.5e-08 32.3 0.3 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain NIF PF03031.18 KOS20234.1 - 2.5e-37 128.1 0.0 3.6e-37 127.6 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2076 PF09849.9 KOS20234.1 - 0.48 10.4 8.4 1.6 8.7 1.8 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Glyco_hydro_67M PF07488.12 KOS20238.1 - 2.1e-141 470.7 0.0 2.8e-141 470.3 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Glyco_hydro_67C PF07477.12 KOS20238.1 - 4.9e-81 271.5 0.1 6.9e-81 271.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus NTP_transf_9 PF04248.12 KOS20239.1 - 2.1e-27 94.9 0.0 2.1e-18 66.0 0.0 3.1 2 1 0 2 2 2 2 Domain of unknown function (DUF427) Coatomer_E PF04733.14 KOS20240.1 - 1.8e-61 208.1 5.3 2.1e-61 207.9 5.3 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 KOS20240.1 - 1.8e-07 31.6 7.9 0.00022 21.6 0.9 4.5 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOS20240.1 - 4.3e-06 26.3 1.1 0.0031 17.3 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS20240.1 - 3.2e-05 24.1 0.6 0.26 11.6 0.2 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOS20240.1 - 4.6e-05 23.8 3.9 0.026 15.1 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20240.1 - 0.00029 20.7 0.0 0.00029 20.7 0.0 5.5 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOS20240.1 - 0.00032 20.7 2.1 0.15 12.3 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS20240.1 - 0.00035 20.8 12.9 0.0055 17.0 0.3 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS20240.1 - 0.00049 20.7 20.3 0.0043 17.8 0.1 6.3 4 1 2 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOS20240.1 - 0.0018 17.9 1.0 0.0018 17.9 1.0 3.9 5 0 0 5 5 5 1 TPR repeat TPR_9 PF13371.6 KOS20240.1 - 0.0025 17.9 5.1 0.029 14.5 0.4 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat Type_III_YscG PF09477.10 KOS20240.1 - 0.0036 17.4 4.3 0.05 13.7 0.3 3.1 2 2 1 3 3 3 1 Bacterial type II secretion system chaperone protein (type_III_yscG) TPR_17 PF13431.6 KOS20240.1 - 0.076 13.4 4.4 2.3 8.8 0.1 4.7 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOS20240.1 - 0.11 13.2 0.6 0.11 13.2 0.6 5.9 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20240.1 - 1.5 9.5 22.4 0.3 11.8 0.5 4.5 4 2 0 4 4 4 0 Tetratricopeptide repeat ANAPC5 PF12862.7 KOS20240.1 - 2.1 8.5 5.3 2.7 8.1 0.1 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 5 Macoilin PF09726.9 KOS20241.1 - 0.19 10.3 8.2 0.21 10.1 8.2 1.1 1 0 0 1 1 1 0 Macoilin family SPX PF03105.19 KOS20241.1 - 1.9 8.4 12.0 2.3 8.1 12.0 1.1 1 0 0 1 1 1 0 SPX domain ATF7IP_BD PF16788.5 KOS20241.1 - 6.6 6.8 11.4 11 6.1 11.0 1.5 1 1 0 1 1 1 0 ATF-interacting protein binding domain FAR1 PF03101.15 KOS20242.1 - 3.2e-08 34.1 0.1 8.7e-08 32.8 0.1 1.6 1 0 0 1 1 1 1 FAR1 DNA-binding domain TFIIA PF03153.13 KOS20242.1 - 0.00075 19.6 19.9 0.00091 19.3 19.9 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit AFT PF08731.11 KOS20242.1 - 0.57 10.6 2.3 0.6 10.5 0.1 2.0 2 0 0 2 2 2 0 Transcription factor AFT Neur_chan_memb PF02932.16 KOS20242.1 - 1.8 8.6 4.4 3.2 7.7 4.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 KOS20242.1 - 1.8 7.2 3.2 2.3 6.9 3.2 1.1 1 0 0 1 1 1 0 Presenilin Peroxin-3 PF04882.12 KOS20242.1 - 9.5 5.1 10.5 8.1 5.3 9.1 1.5 2 0 0 2 2 2 0 Peroxin-3 HMG-CoA_red PF00368.18 KOS20243.1 - 1.1e-106 356.9 3.8 1.6e-106 356.5 3.8 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 KOS20243.1 - 4.6e-43 146.8 0.8 7.2e-43 146.1 0.8 1.3 1 0 0 1 1 1 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 KOS20243.1 - 1.9e-13 50.5 6.7 3.3e-12 46.5 6.7 2.5 1 1 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 KOS20243.1 - 3.7e-08 31.9 5.2 5.3e-08 31.5 5.2 1.1 1 0 0 1 1 1 1 Patched family Rep_fac_C PF08542.11 KOS20245.1 - 9.4e-18 64.4 0.0 1.7e-17 63.6 0.0 1.5 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 KOS20245.1 - 6.9e-16 58.9 0.0 1.9e-15 57.5 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 KOS20245.1 - 9.5e-13 48.2 0.0 2.8e-11 43.5 0.0 2.4 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rad17 PF03215.15 KOS20245.1 - 1.2e-10 41.6 0.0 2.5e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 KOS20245.1 - 6.2e-06 26.0 0.0 2e-05 24.4 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS20245.1 - 2.6e-05 24.7 0.2 0.0011 19.4 0.0 2.7 2 1 1 3 3 3 1 AAA ATPase domain DNA_pol3_delta PF06144.13 KOS20245.1 - 2.9e-05 23.9 0.0 5.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_11 PF13086.6 KOS20245.1 - 4.5e-05 23.4 0.1 9e-05 22.4 0.1 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS20245.1 - 9.5e-05 22.7 0.1 0.0044 17.3 0.0 2.6 2 1 0 2 2 1 1 AAA domain AAA_assoc_2 PF16193.5 KOS20245.1 - 0.00043 20.6 0.1 0.0011 19.2 0.1 1.7 1 0 0 1 1 1 1 AAA C-terminal domain Mg_chelatase PF01078.21 KOS20245.1 - 0.00049 19.5 0.0 0.02 14.3 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KOS20245.1 - 0.0011 19.0 0.0 0.0025 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS20245.1 - 0.0027 18.0 0.2 0.026 14.8 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 KOS20245.1 - 0.0041 16.9 0.0 0.01 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 KOS20245.1 - 0.0062 16.1 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 KOS20245.1 - 0.0078 15.4 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_30 PF13604.6 KOS20245.1 - 0.014 15.1 0.0 0.04 13.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 KOS20245.1 - 0.018 15.1 0.0 0.088 12.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 KOS20245.1 - 0.021 15.1 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOS20245.1 - 0.026 13.8 0.0 0.054 12.7 0.0 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_18 PF13238.6 KOS20245.1 - 0.043 14.4 0.0 0.12 12.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 KOS20245.1 - 0.05 13.6 0.0 0.24 11.4 0.0 1.9 1 1 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.22 KOS20245.1 - 0.063 13.7 0.0 0.17 12.3 0.0 1.8 1 1 0 1 1 1 0 RNA helicase DEAD PF00270.29 KOS20245.1 - 0.12 12.1 0.1 1.3 8.8 0.0 2.3 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_3 PF07726.11 KOS20245.1 - 0.15 11.9 0.0 0.84 9.5 0.0 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2417 PF10329.9 KOS20246.1 - 7.1e-80 267.8 3.4 9.1e-80 267.5 3.4 1.1 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Abhydrolase_1 PF00561.20 KOS20246.1 - 0.0092 15.7 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS20246.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RhoGAP PF00620.27 KOS20247.1 - 2.8e-36 124.6 0.0 6.6e-36 123.4 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain LIM PF00412.22 KOS20247.1 - 0.031 14.5 14.5 0.078 13.2 0.9 3.4 4 0 0 4 4 4 0 LIM domain zf-H2C2_2 PF13465.6 KOS20248.1 - 0.018 15.5 0.4 0.018 15.5 0.4 4.2 7 0 0 7 7 7 0 Zinc-finger double domain zf-C2H2 PF00096.26 KOS20248.1 - 0.021 15.3 25.7 0.023 15.2 0.8 5.1 5 0 0 5 5 5 0 Zinc finger, C2H2 type zf-CHCC PF10276.9 KOS20248.1 - 0.045 13.8 2.6 3.5 7.8 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_4 PF13894.6 KOS20248.1 - 0.056 14.3 22.6 0.097 13.6 1.4 5.2 4 0 0 4 4 4 0 C2H2-type zinc finger zf-BED PF02892.15 KOS20248.1 - 2 8.5 12.9 3.3 7.8 0.0 3.8 4 0 0 4 4 4 0 BED zinc finger PyrI_C PF02748.15 KOS20248.1 - 2.4 8.1 6.5 25 4.9 0.0 2.5 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain tRNA-synt_1b PF00579.25 KOS20249.1 - 3.5e-57 194.0 0.0 4.3e-57 193.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) NAD_binding_7 PF13241.6 KOS20249.1 - 0.16 12.5 0.0 0.4 11.1 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Rtt106 PF08512.12 KOS20251.1 - 2.6e-27 95.0 0.0 5e-27 94.1 0.0 1.5 1 0 0 1 1 1 1 Histone chaperone Rttp106-like PH_18 PF18469.1 KOS20251.1 - 0.0013 18.7 0.0 0.0049 16.9 0.0 1.8 1 1 0 1 1 1 1 Pleckstrin homology domain Nop14 PF04147.12 KOS20251.1 - 0.076 11.2 35.7 0.1 10.8 35.7 1.0 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 KOS20251.1 - 0.27 10.5 29.2 0.4 10.0 29.2 1.1 1 0 0 1 1 1 0 BUD22 Vfa1 PF08432.10 KOS20252.1 - 1.6e-51 175.3 23.5 1.8e-51 175.1 23.5 1.0 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 MTBP_N PF14918.6 KOS20252.1 - 0.015 14.8 2.2 0.023 14.2 2.2 1.3 1 0 0 1 1 1 0 MDM2-binding CDC45 PF02724.14 KOS20252.1 - 0.064 11.6 17.3 0.072 11.4 17.3 1.0 1 0 0 1 1 1 0 CDC45-like protein TP53IP5 PF15331.6 KOS20252.1 - 0.15 12.2 14.8 0.19 11.8 14.8 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Atrophin-1 PF03154.15 KOS20252.1 - 0.22 9.8 19.6 0.3 9.3 19.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family NPR3 PF03666.13 KOS20252.1 - 0.25 10.1 11.7 0.34 9.7 11.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 KOS20252.1 - 0.33 11.1 4.4 0.41 10.8 4.4 1.2 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 KOS20252.1 - 0.85 8.6 2.8 0.99 8.4 2.8 1.2 1 0 0 1 1 1 0 CLN3 protein MCM_bind PF09739.9 KOS20252.1 - 1.3 7.4 8.9 1.5 7.2 8.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SLC12 PF03522.15 KOS20252.1 - 1.9 7.5 11.9 2.2 7.2 11.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 KOS20252.1 - 4.6 6.1 10.8 5.2 5.9 10.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Paramyxo_ncap PF00973.19 KOS20252.1 - 4.8 6.0 7.5 4.7 6.0 7.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein NARP1 PF12569.8 KOS20252.1 - 5.4 5.8 23.0 6.9 5.4 23.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 KOS20252.1 - 9.1 4.9 15.7 11 4.7 15.7 1.1 1 0 0 1 1 1 0 Presenilin DSPc PF00782.20 KOS20253.1 - 2.1e-14 53.5 0.0 3.4e-10 39.8 0.0 2.3 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 KOS20253.1 - 0.0024 18.1 0.0 0.0043 17.3 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 KOS20253.1 - 0.2 11.2 0.0 0.37 10.3 0.0 1.4 1 1 0 1 1 1 0 Protein-tyrosine phosphatase zinc_ribbon_4 PF13717.6 KOS20253.1 - 0.29 11.1 1.8 2.2 8.3 0.3 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Snf7 PF03357.21 KOS20255.1 - 9.6e-40 136.0 5.7 1.1e-39 135.8 5.7 1.1 1 0 0 1 1 1 1 Snf7 NPV_P10 PF05531.12 KOS20255.1 - 4.1e-05 24.0 0.8 0.013 15.9 0.7 2.6 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 KOS20255.1 - 0.026 14.9 4.5 11 6.5 0.0 3.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Zwint PF15556.6 KOS20255.1 - 0.03 13.8 8.9 0.04 13.4 8.9 1.3 1 0 0 1 1 1 0 ZW10 interactor Exonuc_VII_L PF02601.15 KOS20255.1 - 0.04 13.5 1.7 0.051 13.1 1.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FliD_C PF07195.12 KOS20255.1 - 0.048 13.1 3.8 0.5 9.7 0.0 2.7 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Alpha-2-MRAP_C PF06401.11 KOS20255.1 - 0.05 13.6 5.1 0.28 11.1 4.5 2.1 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Peptidase_S46 PF10459.9 KOS20255.1 - 0.052 12.2 3.2 0.065 11.9 3.2 1.0 1 0 0 1 1 1 0 Peptidase S46 DUF2205 PF10224.9 KOS20255.1 - 0.053 13.5 5.6 0.084 12.9 2.9 2.6 2 1 1 3 3 3 0 Short coiled-coil protein bZIP_1 PF00170.21 KOS20255.1 - 0.075 13.1 5.6 7.7 6.7 0.0 3.3 2 1 2 4 4 4 0 bZIP transcription factor DUF848 PF05852.11 KOS20255.1 - 0.085 13.0 7.2 0.16 12.1 6.5 1.9 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) APG6_N PF17675.1 KOS20255.1 - 0.089 13.3 16.1 0.38 11.3 7.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region SlyX PF04102.12 KOS20255.1 - 0.1 13.2 6.6 1.9 9.2 0.0 3.4 1 1 2 3 3 3 0 SlyX Muted PF14942.6 KOS20255.1 - 0.15 12.4 7.3 0.21 11.9 2.1 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein NYD-SP28_assoc PF14775.6 KOS20255.1 - 0.42 10.8 5.3 10 6.3 0.7 3.1 2 1 1 3 3 3 0 Sperm tail C-terminal domain YabA PF06156.13 KOS20255.1 - 0.66 10.6 6.8 7 7.3 4.5 2.6 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 KOS20255.1 - 0.68 9.2 7.0 0.69 9.2 6.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 KOS20255.1 - 1.1 9.3 9.5 1.2 9.2 6.2 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4446 PF14584.6 KOS20255.1 - 2 8.4 5.8 3.2 7.7 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) WD40 PF00400.32 KOS20256.1 - 1.1e-25 89.4 2.5 0.00057 20.6 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat F-box-like PF12937.7 KOS20256.1 - 3.5e-13 49.2 2.4 3.5e-13 49.2 2.4 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KOS20256.1 - 3.4e-05 23.6 1.9 4.7e-05 23.2 0.4 2.0 2 0 0 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 KOS20256.1 - 3.5e-05 24.0 0.6 0.073 13.4 0.0 4.1 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20256.1 - 0.0048 15.6 0.0 0.34 9.5 0.0 2.3 2 0 0 2 2 2 1 Nucleoporin Nup120/160 DMRT-like PF15791.5 KOS20256.1 - 0.021 15.3 2.9 0.021 15.3 2.9 3.0 3 0 0 3 3 3 0 Doublesex-and mab-3-related transcription factor C1 and C2 F-box_4 PF15966.5 KOS20256.1 - 0.087 12.7 0.0 0.23 11.3 0.0 1.8 1 0 0 1 1 1 0 F-box PALB2_WD40 PF16756.5 KOS20256.1 - 0.16 10.9 0.0 0.32 9.9 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain PH_10 PF15411.6 KOS20257.1 - 1.5e-41 141.5 0.3 4e-41 140.1 0.3 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain CDC24 PF06395.11 KOS20257.1 - 1.1e-32 112.2 0.1 2e-32 111.3 0.1 1.5 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 KOS20257.1 - 5e-30 105.1 0.1 8.8e-30 104.3 0.1 1.4 1 0 0 1 1 1 1 RhoGEF domain PB1 PF00564.24 KOS20257.1 - 2.6e-08 33.7 0.0 7.2e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 PB1 domain DUF5645 PF18713.1 KOS20257.1 - 0.048 14.0 0.0 0.1 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5645) DLIC PF05783.11 KOS20257.1 - 1.5 7.5 3.8 3.5 6.3 3.8 1.5 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) GN3L_Grn1 PF08701.11 KOS20258.1 - 1e-24 86.4 17.1 2.5e-24 85.2 17.1 1.7 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 KOS20258.1 - 1.5e-16 60.5 0.0 2.8e-12 46.7 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS20258.1 - 1.6e-07 31.4 0.0 5.9e-07 29.5 0.0 1.9 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 KOS20258.1 - 3.3e-05 23.5 0.0 0.12 11.8 0.0 2.6 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 KOS20258.1 - 6.5e-05 23.0 7.5 0.038 14.0 0.2 3.8 4 1 0 4 4 4 2 Dynamin family FeoB_N PF02421.18 KOS20258.1 - 0.003 17.1 0.5 0.05 13.1 0.2 2.7 2 1 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 KOS20258.1 - 0.05 12.6 0.2 0.05 12.6 0.2 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB BUD22 PF09073.10 KOS20258.1 - 1.8 7.8 37.4 3.9 6.7 37.4 1.5 1 1 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 KOS20258.1 - 5 5.1 37.6 7.6 4.5 37.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi SF3A2 PF16835.5 KOS20259.1 - 1.1e-34 118.7 0.1 1.6e-34 118.1 0.1 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 KOS20259.1 - 3.9e-06 27.1 0.9 6.8e-06 26.3 0.9 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type CactinC_cactus PF09732.9 KOS20259.1 - 2.2e-05 24.4 0.1 3.3e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein PRP4 PF08799.11 KOS20259.1 - 0.062 12.9 1.5 0.11 12.1 1.5 1.4 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like CBFD_NFYB_HMF PF00808.23 KOS20261.1 - 7.6e-09 35.7 0.0 1.9e-08 34.5 0.0 1.7 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOS20261.1 - 0.00069 20.0 2.4 0.00077 19.8 0.0 2.2 2 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 KOS20261.1 - 0.03 14.4 0.0 0.045 13.9 0.0 1.4 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Nucleo_P87 PF07267.11 KOS20261.1 - 5 5.9 14.7 7.6 5.3 14.7 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CRC_subunit PF08624.10 KOS20262.1 - 1.6e-52 177.5 0.1 2.3e-52 177.0 0.1 1.2 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit RNB PF00773.19 KOS20263.1 - 7.2e-98 327.9 0.1 1.1e-97 327.3 0.1 1.3 1 0 0 1 1 1 1 RNB domain Rrp44_S1 PF17215.3 KOS20263.1 - 4.7e-32 109.8 0.2 1.3e-31 108.4 0.2 1.8 1 0 0 1 1 1 1 S1 domain Rrp44_CSD1 PF17216.3 KOS20263.1 - 1.7e-31 108.9 0.0 5.5e-31 107.3 0.0 1.9 1 1 0 1 1 1 1 Rrp44-like cold shock domain OB_Dis3 PF17849.1 KOS20263.1 - 3.7e-20 71.7 0.0 9.3e-20 70.4 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 KOS20263.1 - 1.3e-09 38.5 0.1 4.5e-09 36.7 0.0 2.0 2 0 0 2 2 2 1 PIN domain CSD2 PF17876.1 KOS20263.1 - 1.4e-06 28.4 0.1 0.017 15.3 0.0 2.9 3 0 0 3 3 3 2 Cold shock domain Dis3l2_C_term PF17877.1 KOS20263.1 - 0.0057 17.0 0.0 0.028 14.7 0.0 2.2 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal TcfC PF16967.5 KOS20263.1 - 0.12 11.9 0.0 1.5 8.3 0.0 2.4 2 0 0 2 2 2 0 E-set like domain Cys_Met_Meta_PP PF01053.20 KOS20264.1 - 2.1e-140 467.6 0.1 2.5e-140 467.4 0.1 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOS20264.1 - 2.7e-06 26.8 0.1 4.4e-06 26.1 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 KOS20264.1 - 4.4e-06 25.9 1.0 5.8e-06 25.5 0.3 1.5 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS20264.1 - 9.5e-06 25.1 0.7 1.9e-05 24.2 0.7 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family 2-Hacid_dh PF00389.30 KOS20264.1 - 0.02 14.6 0.1 0.034 13.8 0.1 1.4 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Big_3_5 PF16640.5 KOS20264.1 - 0.64 10.2 5.5 1.3 9.2 2.6 2.4 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) F-box-like PF12937.7 KOS20265.1 - 0.0039 17.1 0.4 0.013 15.4 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 KOS20265.1 - 0.062 13.2 0.1 0.25 11.3 0.1 2.1 1 0 0 1 1 1 0 F-box domain Sporozoite_P67 PF05642.11 KOS20266.1 - 0.53 8.3 4.8 0.49 8.4 4.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pex14_N PF04695.13 KOS20266.1 - 3.8 8.1 7.6 1.5 9.5 0.9 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Lactamase_B_2 PF12706.7 KOS20267.1 - 9.9e-08 31.7 3.5 9.6e-05 22.0 3.5 3.1 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 KOS20267.1 - 2.3e-05 24.5 0.3 4.5e-05 23.6 0.1 1.6 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 KOS20267.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Glyco_transf_34 PF05637.12 KOS20268.1 - 1.9e-07 31.1 2.3 6.4e-07 29.3 2.3 1.7 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 KOS20268.1 - 1.1e-05 25.6 0.0 4.6e-05 23.5 0.0 1.8 1 1 1 2 2 2 1 Nucleotide-diphospho-sugar transferase DUF273 PF03314.14 KOS20268.1 - 0.011 15.4 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF273 Toxin_7 PF05980.12 KOS20269.1 - 0.12 12.7 6.7 0.19 12.0 6.7 1.4 1 1 0 1 1 1 0 Toxin 7 Toxin_12 PF07740.12 KOS20269.1 - 0.14 12.8 3.0 0.14 12.8 3.0 2.1 2 1 0 2 2 2 0 Ion channel inhibitory toxin Tachystatin_A PF11406.8 KOS20269.1 - 0.59 10.2 7.0 1.1 9.3 7.0 1.6 1 1 0 1 1 1 0 Antimicrobial peptide tachystatin A PS_Dcarbxylase PF02666.15 KOS20271.1 - 2.4e-46 157.8 0.0 3.4e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase RnfC_N PF13375.6 KOS20271.1 - 0.11 12.5 0.3 5.6 7.0 0.1 2.4 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain Biotin_lipoyl_2 PF13533.6 KOS20271.1 - 0.19 11.6 0.4 1.2 9.0 0.1 2.4 2 0 0 2 2 2 0 Biotin-lipoyl like HTH_30 PF13556.6 KOS20272.1 - 0.00011 21.9 0.9 0.00056 19.6 0.1 2.4 3 0 0 3 3 3 1 PucR C-terminal helix-turn-helix domain DUF4407 PF14362.6 KOS20272.1 - 0.00012 21.5 1.0 0.00017 21.1 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4407) UPF0242 PF06785.11 KOS20272.1 - 0.00025 21.2 5.3 0.00039 20.6 1.1 2.0 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus ApoLp-III PF07464.11 KOS20272.1 - 0.0045 17.1 1.4 0.077 13.1 0.1 2.3 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 KOS20272.1 - 0.0046 17.0 2.4 0.17 11.9 0.3 3.1 2 1 1 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin_2 PF14523.6 KOS20272.1 - 0.014 15.8 6.1 0.5 10.8 2.4 3.2 1 1 2 3 3 3 0 Syntaxin-like protein GAS PF13851.6 KOS20272.1 - 0.014 14.7 5.8 3.1 7.1 0.7 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Occludin_ELL PF07303.13 KOS20272.1 - 0.017 15.8 2.9 0.47 11.2 0.1 2.9 1 1 2 4 4 4 0 Occludin homology domain DUF948 PF06103.11 KOS20272.1 - 0.021 15.1 4.2 9.5 6.6 1.0 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) SKA2 PF16740.5 KOS20272.1 - 0.032 14.0 4.3 3.9 7.3 0.1 3.5 1 1 2 4 4 4 0 Spindle and kinetochore-associated protein 2 KIAA1430 PF13879.6 KOS20272.1 - 0.039 14.7 0.2 0.13 13.0 0.0 2.0 2 1 0 2 2 2 0 KIAA1430 homologue Cep57_CLD_2 PF14197.6 KOS20272.1 - 0.051 13.7 1.9 1.1 9.4 0.2 3.0 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 ZapB PF06005.12 KOS20272.1 - 0.077 13.4 1.0 0.98 9.9 0.1 2.5 2 0 0 2 2 2 0 Cell division protein ZapB SHE3 PF17078.5 KOS20272.1 - 0.08 12.6 2.2 0.076 12.7 0.4 1.8 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Prominin PF05478.11 KOS20272.1 - 0.081 10.9 2.9 0.31 8.9 1.0 2.0 1 1 1 2 2 2 0 Prominin DUF4515 PF14988.6 KOS20272.1 - 0.081 12.7 3.4 0.24 11.2 0.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4515) ANTH PF07651.16 KOS20272.1 - 0.089 11.8 1.8 0.17 10.8 0.1 2.1 1 1 0 2 2 2 0 ANTH domain ApoO PF09769.9 KOS20272.1 - 0.09 12.7 0.2 0.36 10.8 0.0 2.0 2 1 0 2 2 2 0 Apolipoprotein O DUF1664 PF07889.12 KOS20272.1 - 0.096 12.7 6.7 3.9 7.5 3.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CdvA PF18822.1 KOS20272.1 - 0.1 12.4 6.3 0.63 9.9 0.1 3.2 2 1 1 3 3 3 0 CdvA-like coiled-coil domain Thiamine_BP PF01910.17 KOS20272.1 - 0.11 12.4 0.3 0.51 10.3 0.1 2.0 2 0 0 2 2 2 0 Thiamine-binding protein JIP_LZII PF16471.5 KOS20272.1 - 0.22 11.7 3.5 5.1 7.4 0.2 2.7 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II LPP PF04728.13 KOS20272.1 - 0.23 11.9 4.2 16 5.9 0.2 3.9 2 1 1 3 3 3 0 Lipoprotein leucine-zipper FAM76 PF16046.5 KOS20272.1 - 0.29 10.5 1.1 0.46 9.8 1.1 1.4 1 0 0 1 1 1 0 FAM76 protein Fib_alpha PF08702.10 KOS20272.1 - 0.38 10.9 3.3 1.1 9.4 0.3 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Syntaxin-6_N PF09177.11 KOS20272.1 - 0.48 11.0 3.9 17 6.0 0.9 2.9 1 1 1 2 2 2 0 Syntaxin 6, N-terminal YlqD PF11068.8 KOS20272.1 - 0.59 10.5 4.2 2.1 8.8 0.8 2.4 2 1 0 2 2 2 0 YlqD protein DUF4618 PF15397.6 KOS20272.1 - 0.65 9.4 5.8 3.3 7.1 3.8 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) Sec5 PF15469.6 KOS20272.1 - 0.87 9.4 6.1 1 9.2 0.4 2.8 2 1 2 4 4 4 0 Exocyst complex component Sec5 DUF883 PF05957.13 KOS20272.1 - 1.9 9.1 8.6 7.7 7.2 0.6 3.4 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) CLZ PF16526.5 KOS20272.1 - 2.2 8.7 7.1 5.8 7.3 0.7 2.7 2 1 1 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fzo_mitofusin PF04799.13 KOS20272.1 - 2.2 7.8 6.3 5.3 6.6 0.5 2.9 2 1 2 4 4 4 0 fzo-like conserved region Nucleos_tra2_C PF07662.13 KOS20273.1 - 9.8e-58 195.4 4.5 4.2e-57 193.3 0.6 3.0 3 2 0 3 3 3 1 Na+ dependent nucleoside transporter C-terminus Nucleos_tra2_N PF01773.20 KOS20273.1 - 1.5e-21 76.8 3.5 1.5e-21 76.8 3.5 2.8 1 1 1 2 2 2 1 Na+ dependent nucleoside transporter N-terminus DUF3290 PF11694.8 KOS20273.1 - 0.04 13.9 0.5 0.04 13.9 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) HRI1 PF16815.5 KOS20274.1 - 7.3e-35 120.7 9.1 8e-35 120.6 9.1 1.0 1 0 0 1 1 1 1 Protein HRI1 CLN3 PF02487.17 KOS20275.1 - 1.8e-146 488.2 0.1 2.1e-146 488.0 0.1 1.0 1 0 0 1 1 1 1 CLN3 protein MFS_1 PF07690.16 KOS20275.1 - 4.1e-05 22.7 23.5 0.00079 18.4 23.9 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Cyt-b5 PF00173.28 KOS20278.1 - 1.5e-21 76.3 0.6 1.7e-21 76.1 0.6 1.0 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HhH-GPD PF00730.25 KOS20279.1 - 3.8e-18 65.9 0.0 7.2e-18 65.0 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 KOS20279.1 - 1.3e-07 31.1 0.0 3e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix motif U79_P34 PF03064.16 KOS20279.1 - 0.13 11.6 0.8 0.2 11.0 0.8 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 zf-AN1 PF01428.16 KOS20280.1 - 2.2e-13 50.1 5.2 2.2e-13 50.1 5.2 1.5 1 1 0 1 1 1 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 KOS20280.1 - 0.02 15.2 4.8 0.02 15.2 4.8 1.5 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Nucleopor_Nup85 PF07575.13 KOS20281.1 - 4e-16 58.7 0.0 2.2e-14 53.0 0.0 2.6 2 1 0 2 2 2 1 Nup85 Nucleoporin Nop14 PF04147.12 KOS20281.1 - 3.9 5.6 6.9 9.2 4.3 5.9 1.8 2 0 0 2 2 2 0 Nop14-like family ADH_N PF08240.12 KOS20282.1 - 2.4e-26 91.8 2.2 5.5e-26 90.6 2.2 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS20282.1 - 1.3e-20 73.7 0.5 2.4e-20 72.8 0.5 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 KOS20282.1 - 6.3e-05 22.4 1.3 0.00012 21.5 1.3 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pep_deformylase PF01327.21 KOS20282.1 - 0.04 13.5 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 Polypeptide deformylase Pkinase PF00069.25 KOS20283.1 - 3.5e-11 43.0 0.0 5.5e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain HEAT PF02985.22 KOS20283.1 - 1e-07 31.5 0.5 0.1 12.9 0.0 5.1 4 0 0 4 4 4 1 HEAT repeat Cnd1 PF12717.7 KOS20283.1 - 5.4e-06 26.5 0.2 1.2e-05 25.4 0.2 1.6 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS20283.1 - 1.9e-05 24.9 0.2 0.0002 21.7 0.1 2.8 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 KOS20283.1 - 9.6e-05 22.8 0.2 0.79 10.3 0.1 3.7 4 0 0 4 4 3 2 HEAT-like repeat Pkinase_Tyr PF07714.17 KOS20283.1 - 0.00013 21.3 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Vac14_Fab1_bd PF12755.7 KOS20283.1 - 0.015 15.9 0.1 14 6.3 0.0 2.9 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region Kinase-like PF14531.6 KOS20283.1 - 0.12 11.6 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CLASP_N PF12348.8 KOS20283.1 - 0.15 11.6 0.2 0.52 9.8 0.2 1.8 1 1 0 1 1 1 0 CLASP N terminal Adaptin_N PF01602.20 KOS20283.1 - 0.19 10.2 0.1 0.64 8.5 0.0 1.6 1 1 0 2 2 2 0 Adaptin N terminal region IFRD PF05004.13 KOS20283.1 - 0.22 10.6 0.2 1.9 7.5 0.0 2.2 2 1 1 3 3 3 0 Interferon-related developmental regulator (IFRD) Aconitase PF00330.20 KOS20284.1 - 9e-149 496.4 0.0 1.1e-148 496.1 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOS20284.1 - 2.7e-37 128.0 0.0 4.1e-37 127.4 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 KOS20284.1 - 0.11 11.2 0.0 0.21 10.2 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF521) DUF2462 PF09495.10 KOS20285.1 - 3.1e-15 56.7 8.9 3.1e-15 56.7 8.9 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF2462) Ribosomal_S10 PF00338.22 KOS20286.1 - 3.5e-25 88.1 0.4 4.3e-25 87.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e MRP-S28 PF10213.9 KOS20287.1 - 9.7e-42 142.4 0.0 1.6e-41 141.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein LETM1 PF07766.13 KOS20288.1 - 7.5e-10 38.6 0.2 7.5e-10 38.6 0.2 2.8 3 0 0 3 3 3 1 LETM1-like protein Cwf_Cwc_15 PF04889.12 KOS20288.1 - 0.00036 20.4 3.4 0.00054 19.8 3.4 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Pex14_N PF04695.13 KOS20288.1 - 0.59 10.8 11.1 0.98 10.1 11.1 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 KOS20288.1 - 0.61 8.8 3.3 0.81 8.4 3.3 1.1 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 KOS20288.1 - 0.68 9.9 16.1 0.9 9.5 16.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 KOS20288.1 - 1.2 8.0 13.5 1.6 7.6 13.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TMEM247 PF15444.6 KOS20288.1 - 2.5 8.1 6.1 3.7 7.5 6.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 UPF0560 PF10577.9 KOS20288.1 - 2.7 6.4 9.7 3.7 5.9 9.7 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 FTZ PF03867.14 KOS20288.1 - 2.7 7.4 7.1 4 6.9 7.1 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region Activator_LAG-3 PF11498.8 KOS20288.1 - 3.6 6.4 27.0 5 6.0 27.0 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 SelP_N PF04592.14 KOS20288.1 - 7.2 5.9 13.0 11 5.4 13.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SCP2 PF02036.17 KOS20289.1 - 6.5e-22 77.9 1.3 7.5e-22 77.7 1.3 1.0 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 KOS20289.1 - 0.0013 19.0 0.3 0.0017 18.7 0.3 1.2 1 0 0 1 1 1 1 Alkyl sulfatase C-terminal SCP2_2 PF13530.6 KOS20289.1 - 0.068 13.6 0.1 0.098 13.1 0.1 1.2 1 0 0 1 1 1 0 Sterol carrier protein domain NMO PF03060.15 KOS20290.1 - 4.2e-23 82.2 8.8 1.8e-21 76.9 5.1 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 KOS20290.1 - 0.011 14.8 7.9 0.018 14.1 7.9 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOS20290.1 - 0.021 13.9 12.2 0.033 13.2 12.2 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase Aldo_ket_red PF00248.21 KOS20291.1 - 4.2e-67 226.4 0.0 4.7e-67 226.2 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DEAD PF00270.29 KOS20292.1 - 8.3e-17 61.5 0.0 1.2e-16 61.0 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 KOS20292.1 - 8.2e-13 48.7 0.0 1.1e-12 48.3 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 KOS20292.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 KOS20292.1 - 0.16 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Terminase_6 PF03237.15 KOS20292.1 - 0.18 11.5 0.0 0.26 10.9 0.0 1.2 1 0 0 1 1 1 0 Terminase-like family UTP15_C PF09384.10 KOS20293.1 - 1e-46 158.2 0.0 1.5e-46 157.7 0.0 1.2 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 KOS20293.1 - 2.3e-12 47.2 8.4 0.0053 17.6 0.1 6.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20293.1 - 2.2e-06 27.8 0.0 0.36 11.1 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RAB3GAP2_N PF14655.6 KOS20293.1 - 0.052 12.8 0.2 1.7 7.8 0.1 2.7 2 1 1 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Ran-binding PF05508.11 KOS20293.1 - 0.14 11.1 0.0 0.19 10.7 0.0 1.2 1 0 0 1 1 1 0 RanGTP-binding protein C2 PF00168.30 KOS20294.1 - 7.5e-16 58.3 0.0 1.4e-15 57.4 0.0 1.5 1 0 0 1 1 1 1 C2 domain EPL1 PF10513.9 KOS20294.1 - 0.0066 16.8 8.3 0.013 15.9 8.3 1.5 1 0 0 1 1 1 1 Enhancer of polycomb-like Spt20 PF12090.8 KOS20294.1 - 0.074 12.6 38.3 0.15 11.7 38.3 1.4 1 0 0 1 1 1 0 Spt20 family MDM10 PF12519.8 KOS20294.1 - 0.14 10.9 7.8 0.21 10.4 7.8 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 KOS20294.1 - 0.24 11.4 6.4 0.54 10.3 6.4 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 KOS20294.1 - 0.33 10.4 10.3 0.54 9.7 10.3 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 KOS20294.1 - 0.88 8.5 9.2 1.3 8.0 9.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 KOS20294.1 - 1 9.1 10.9 1.8 8.3 10.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Endostatin PF06482.11 KOS20294.1 - 1.1 8.7 14.8 3 7.2 14.8 1.7 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin EOS1 PF12326.8 KOS20294.1 - 1.3 8.9 2.7 2.2 8.2 2.7 1.3 1 0 0 1 1 1 0 N-glycosylation protein FAM76 PF16046.5 KOS20294.1 - 1.7 7.9 14.0 2.7 7.3 14.0 1.2 1 0 0 1 1 1 0 FAM76 protein Presenilin PF01080.17 KOS20294.1 - 1.8 7.2 16.7 2.9 6.6 16.7 1.2 1 0 0 1 1 1 0 Presenilin DUF4770 PF15994.5 KOS20294.1 - 2 8.6 12.8 4 7.6 12.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RBM39linker PF15519.6 KOS20294.1 - 2.1 9.5 10.8 12 7.1 10.8 2.3 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein Plasmodium_Vir PF05795.11 KOS20294.1 - 2.4 7.5 5.1 4.7 6.5 5.1 1.4 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CPSF100_C PF13299.6 KOS20294.1 - 2.8 8.1 8.6 6.3 7.0 8.6 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Serinc PF03348.15 KOS20294.1 - 3.3 6.5 4.3 4.4 6.1 4.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF1387 PF07139.11 KOS20294.1 - 3.3 7.3 13.6 1.4 8.6 9.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) FAM60A PF15396.6 KOS20294.1 - 3.5 7.6 7.2 7.2 6.5 7.2 1.5 1 0 0 1 1 1 0 Protein Family FAM60A TMEM51 PF15345.6 KOS20294.1 - 3.5 7.4 13.4 7.5 6.3 13.4 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 GREB1 PF15782.5 KOS20294.1 - 4.3 4.3 9.6 5.7 3.9 9.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 KOS20294.1 - 4.6 6.7 19.3 12 5.4 19.3 1.6 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sec62 PF03839.16 KOS20294.1 - 8.6 5.8 8.5 14 5.1 8.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 GAF_2 PF13185.6 KOS20295.1 - 1e-08 35.6 0.1 1.4e-08 35.1 0.1 1.2 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 KOS20295.1 - 0.0014 19.3 0.1 0.0016 19.1 0.1 1.2 1 0 0 1 1 1 1 GAF domain GAF_3 PF13492.6 KOS20295.1 - 0.14 12.5 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 GAF domain Zn_clus PF00172.18 KOS20296.1 - 2.7e-08 33.8 12.4 4.1e-08 33.2 12.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Helicase_C PF00271.31 KOS20297.1 - 7e-06 26.4 0.1 1.6e-05 25.2 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HET PF06985.11 KOS20298.1 - 3.9e-25 88.9 0.0 7.1e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF647 PF04884.14 KOS20299.1 - 0.084 12.5 0.1 0.093 12.3 0.1 1.2 1 0 0 1 1 1 0 Vitamin B6 photo-protection and homoeostasis Tektin PF03148.14 KOS20299.1 - 0.092 11.5 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 Tektin family IRK PF01007.20 KOS20299.1 - 0.2 11.4 0.0 0.25 11.1 0.0 1.1 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain Apolipoprotein PF01442.18 KOS20299.1 - 0.23 11.3 5.1 0.22 11.4 1.0 2.0 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DnaJ PF00226.31 KOS20300.1 - 1e-10 41.6 0.1 1.6e-10 41.0 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain PC4 PF02229.16 KOS20301.1 - 7.3e-23 80.0 0.0 1.2e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) PXA PF02194.15 KOS20302.1 - 3.8e-32 111.7 0.6 6.9e-32 110.9 0.6 1.4 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 KOS20302.1 - 7.6e-19 68.3 0.5 5.6e-18 65.6 0.0 2.7 3 0 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 KOS20302.1 - 2.6e-07 30.6 0.0 7.1e-07 29.2 0.0 1.8 1 0 0 1 1 1 1 PX domain DUF4666 PF15697.5 KOS20302.1 - 0.013 16.1 2.4 0.055 14.2 2.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) DUF932 PF06067.11 KOS20302.1 - 0.09 12.5 0.7 0.17 11.6 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF932) Pex19 PF04614.12 KOS20303.1 - 1.2e-65 221.7 8.5 1.2e-65 221.7 8.5 1.4 2 0 0 2 2 2 1 Pex19 protein family AraC_binding PF02311.19 KOS20303.1 - 0.15 12.0 0.4 3.6 7.5 0.2 2.4 1 1 1 2 2 2 0 AraC-like ligand binding domain FliE PF02049.18 KOS20303.1 - 2.1 8.5 7.2 4.2 7.6 0.3 3.5 2 1 1 3 3 3 0 Flagellar hook-basal body complex protein FliE ABC1 PF03109.16 KOS20304.1 - 1.9e-32 111.9 0.0 2.9e-32 111.3 0.0 1.3 1 0 0 1 1 1 1 ABC1 family CDH-cyt PF16010.5 KOS20305.1 - 1.6e-18 67.1 0.0 3.2e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Cytochrom_B561 PF03188.16 KOS20305.1 - 2.8e-08 34.0 10.3 2.8e-08 34.0 10.3 1.7 2 0 0 2 2 2 1 Eukaryotic cytochrome b561 DUF2427 PF10348.9 KOS20305.1 - 0.00034 20.4 2.6 0.00034 20.4 2.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2427) DUF4079 PF13301.6 KOS20305.1 - 0.0072 16.5 5.5 0.014 15.6 3.3 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF4079) DUF998 PF06197.13 KOS20305.1 - 0.011 15.4 6.0 0.011 15.4 6.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF998) SARAF PF06682.12 KOS20305.1 - 0.014 15.1 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis PDR_CDR PF06422.12 KOS20305.1 - 0.045 13.6 1.4 6.5 6.7 0.1 2.5 2 0 0 2 2 2 0 CDR ABC transporter STE3 PF02076.15 KOS20305.1 - 0.046 12.9 4.2 0.079 12.2 4.2 1.4 1 1 0 1 1 1 0 Pheromone A receptor Bax1-I PF01027.20 KOS20305.1 - 1.1 9.0 13.2 0.49 10.2 10.2 1.8 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 MFS_1 PF07690.16 KOS20306.1 - 9.3e-26 90.6 29.3 9.3e-26 90.6 29.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOS20306.1 - 0.007 14.8 1.2 0.011 14.2 1.2 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOS20306.1 - 0.01 14.7 9.0 0.034 13.0 8.9 1.8 1 1 1 2 2 2 0 Sugar (and other) transporter MFS_1_like PF12832.7 KOS20306.1 - 0.37 9.6 16.3 0.027 13.3 2.4 3.3 3 1 1 4 4 4 0 MFS_1 like family Ureidogly_lyase PF04115.12 KOS20307.1 - 4.1e-54 183.2 0.0 5e-54 182.9 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase Ribosomal_L44 PF00935.19 KOS20309.1 - 3.5e-37 126.7 12.7 5e-37 126.2 12.7 1.2 1 0 0 1 1 1 1 Ribosomal protein L44 Amidohydro_3 PF07969.11 KOS20310.1 - 1e-57 196.7 5.4 1.6e-57 196.0 5.4 1.2 1 0 0 1 1 1 1 Amidohydrolase family Y_phosphatase3 PF13350.6 KOS20311.1 - 2.1e-49 168.6 0.0 2.7e-49 168.2 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KOS20311.1 - 0.025 14.7 0.0 0.04 14.0 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 KOS20311.1 - 0.05 13.2 0.0 0.072 12.7 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 KOS20311.1 - 0.064 12.8 0.0 0.084 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase ALAD PF00490.21 KOS20312.1 - 2.2e-121 404.9 0.0 2.5e-121 404.7 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Acyl_transf_3 PF01757.22 KOS20313.1 - 8.5e-37 127.0 33.0 2.5e-36 125.4 33.0 1.7 1 1 0 1 1 1 1 Acyltransferase family Zip PF02535.22 KOS20314.1 - 0.0053 16.0 4.4 0.0054 16.0 4.4 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter TFIIA PF03153.13 KOS20314.1 - 0.0085 16.1 3.0 0.0088 16.1 3.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SelP_N PF04592.14 KOS20314.1 - 0.98 8.8 23.0 1.4 8.3 23.0 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FAM76 PF16046.5 KOS20314.1 - 1.1 8.5 4.1 1.4 8.2 4.1 1.1 1 0 0 1 1 1 0 FAM76 protein NicO PF03824.16 KOS20314.1 - 9.2 5.5 14.1 12 5.1 14.1 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein MARVEL PF01284.23 KOS20315.1 - 1.5e-14 54.3 18.2 1.9e-14 53.9 18.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF2070 PF09843.9 KOS20315.1 - 9.1 4.4 9.2 11 4.2 9.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ParA PF10609.9 KOS20316.1 - 3.4e-94 314.9 0.0 3.9e-94 314.7 0.0 1.0 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 KOS20316.1 - 1.1e-08 35.2 0.0 2.8e-08 33.9 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 KOS20316.1 - 5e-06 26.5 0.0 1.3e-05 25.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 KOS20316.1 - 0.00068 18.9 0.1 0.0046 16.2 0.0 2.2 2 1 1 3 3 3 1 Anion-transporting ATPase RsgA_GTPase PF03193.16 KOS20316.1 - 0.0022 17.9 0.0 0.0039 17.1 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase Fer4_NifH PF00142.18 KOS20316.1 - 0.0043 16.5 0.0 0.56 9.6 0.0 2.3 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 KOS20316.1 - 0.0085 15.4 0.0 0.015 14.6 0.0 1.4 1 1 0 1 1 1 1 ATPase MipZ AAA_25 PF13481.6 KOS20316.1 - 0.0094 15.5 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS20316.1 - 0.01 16.2 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 KOS20316.1 - 0.016 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 KOS20316.1 - 0.016 15.1 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_26 PF13500.6 KOS20316.1 - 0.024 14.5 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain CBP_BcsQ PF06564.12 KOS20316.1 - 0.045 13.2 0.0 0.27 10.7 0.0 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ ABC_tran PF00005.27 KOS20316.1 - 0.053 14.0 0.0 0.08 13.5 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Ras PF00071.22 KOS20316.1 - 0.095 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Ras family CLP1_P PF16575.5 KOS20316.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DAP3 PF10236.9 KOS20316.1 - 0.16 11.1 0.0 0.22 10.7 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 KOS20316.1 - 0.16 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 KOS20316.1 - 0.17 10.9 0.1 0.25 10.3 0.1 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 KOS20316.1 - 0.21 10.9 0.0 0.31 10.3 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin DUF1279 PF06916.13 KOS20317.1 - 3.8e-24 85.0 0.0 5.3e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) REF PF05755.12 KOS20317.1 - 0.096 12.5 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 Rubber elongation factor protein (REF) Ribosomal_L17 PF01196.19 KOS20318.1 - 1.8e-27 96.0 0.0 3.5e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L17 DALR_1 PF05746.15 KOS20318.1 - 0.09 13.0 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 DALR anticodon binding domain AvrPtoB_bdg PF16847.5 KOS20318.1 - 0.15 12.6 0.1 0.34 11.4 0.1 1.6 1 0 0 1 1 1 0 Avirulence AvrPtoB, BAK1-binding domain IATP PF04568.12 KOS20318.1 - 1.4 9.4 4.9 0.56 10.7 1.7 1.9 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP AIM5 PF17050.5 KOS20319.1 - 1.9e-21 76.6 2.6 1.9e-21 76.6 2.6 2.6 2 1 0 2 2 2 1 Altered inheritance of mitochondria 5 Caskin-Pro-rich PF16907.5 KOS20319.1 - 0.0045 17.5 0.2 0.0045 17.5 0.2 2.4 2 1 0 2 2 2 1 Proline rich region of Caskin proteins DUF5471 PF17565.2 KOS20319.1 - 3.7 7.9 9.5 0.85 10.0 0.3 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5471) Med26 PF08711.11 KOS20320.1 - 9.9e-05 22.3 0.6 0.00016 21.6 0.6 1.3 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Prothymosin PF03247.14 KOS20320.1 - 0.034 14.6 25.3 0.045 14.2 25.3 1.2 1 0 0 1 1 1 0 Prothymosin/parathymosin family DUF913 PF06025.12 KOS20320.1 - 1 8.3 5.8 1.3 7.9 5.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 KOS20320.1 - 3.5 7.4 11.8 3.7 7.3 11.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 KOS20320.1 - 4.6 7.2 4.7 5.1 7.1 4.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ORC3_N PF07034.11 KOS20321.1 - 6.1e-30 104.4 0.2 4.6e-14 52.3 0.0 3.0 2 1 1 3 3 3 2 Origin recognition complex (ORC) subunit 3 N-terminus ORC_WH_C PF18137.1 KOS20321.1 - 8.5e-12 45.3 0.9 2.1e-07 31.1 0.1 2.9 2 1 1 3 3 3 2 Origin recognition complex winged helix C-terminal DUF4530 PF15039.6 KOS20321.1 - 1.3 9.2 4.6 19 5.5 3.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) DUF4611 PF15387.6 KOS20321.1 - 3.8 7.8 8.2 17 5.7 7.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 KOS20321.1 - 4.3 7.0 5.3 12 5.5 5.3 1.7 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 KOS20321.1 - 5.8 6.2 7.2 13 5.0 7.2 1.6 1 0 0 1 1 1 0 NOA36 protein Sec63 PF02889.16 KOS20322.1 - 1.7e-165 548.5 0.4 2e-92 309.0 0.0 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 KOS20322.1 - 6.4e-51 172.6 0.1 2.3e-29 102.4 0.1 3.2 3 0 0 3 3 3 2 DEAD/DEAH box helicase Helicase_PWI PF18149.1 KOS20322.1 - 2.4e-33 114.6 2.1 3.4e-33 114.1 0.4 2.2 2 0 0 2 2 2 1 N-terminal helicase PWI domain ResIII PF04851.15 KOS20322.1 - 2.3e-24 86.3 0.0 1.8e-14 54.1 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 KOS20322.1 - 3.8e-10 40.1 0.0 3.7e-07 30.5 0.0 3.6 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOS20322.1 - 5.4e-07 30.0 0.1 0.0024 18.1 0.0 3.1 2 1 0 2 2 2 2 AAA domain T2SSE PF00437.20 KOS20322.1 - 0.00026 20.2 0.0 0.35 9.9 0.0 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein PhoH PF02562.16 KOS20322.1 - 0.0018 17.7 0.0 0.15 11.5 0.0 2.6 2 0 0 2 2 2 1 PhoH-like protein UvrD-helicase PF00580.21 KOS20322.1 - 0.032 13.8 0.0 1.8 8.0 0.0 2.7 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PWWP PF00855.17 KOS20323.1 - 4.3e-16 59.1 0.0 4.3e-16 59.1 0.0 3.2 3 1 1 4 4 4 1 PWWP domain NPL4 PF05021.15 KOS20324.1 - 7.3e-135 449.2 0.0 9.1e-135 448.9 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 KOS20324.1 - 4.4e-66 221.5 0.0 6.4e-66 221.0 0.0 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region CPSase_L_D2 PF02786.17 KOS20325.1 - 1.2e-111 371.3 0.0 5.2e-84 281.0 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 KOS20325.1 - 1.6e-40 138.3 0.2 4.5e-40 136.8 0.2 1.9 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 KOS20325.1 - 7.5e-22 77.7 0.0 7.4e-11 41.9 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOS20325.1 - 6.3e-19 68.3 0.4 6.4e-09 35.6 0.1 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 KOS20325.1 - 9.1e-12 44.9 0.0 6.1e-05 22.8 0.0 2.9 2 1 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_5 PF13549.6 KOS20325.1 - 1.2e-05 24.9 0.1 0.035 13.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain GARS_A PF01071.19 KOS20325.1 - 1.7e-05 24.7 0.1 0.085 12.6 0.1 2.9 2 0 0 2 2 2 2 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain RimK PF08443.11 KOS20325.1 - 6.8e-05 22.5 0.0 0.19 11.3 0.0 2.7 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 KOS20325.1 - 0.00012 22.2 0.1 0.42 10.7 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain Sec66 PF09802.9 KOS20326.1 - 1.8e-78 262.3 0.0 2e-78 262.1 0.0 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 RGS_DHEX PF18148.1 KOS20326.1 - 0.041 14.0 2.5 0.067 13.3 2.5 1.3 1 0 0 1 1 1 0 Regulator of G-protein signalling DHEX domain PEP-utilisers_N PF05524.13 KOS20326.1 - 0.055 13.6 1.1 0.092 12.9 0.8 1.5 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal tRNA_synt_1c_R1 PF04558.15 KOS20326.1 - 0.055 13.5 0.1 0.089 12.8 0.1 1.2 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 DUF3848 PF12959.7 KOS20326.1 - 0.066 13.3 0.0 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) FAP PF07174.11 KOS20327.1 - 0.0018 17.8 16.6 0.0018 17.8 16.6 2.1 2 0 0 2 2 2 1 Fibronectin-attachment protein (FAP) Spt20 PF12090.8 KOS20328.1 - 0.56 9.8 7.4 12 5.4 0.0 2.0 2 0 0 2 2 2 0 Spt20 family Dicty_REP PF05086.12 KOS20328.1 - 0.86 7.5 3.1 0.9 7.4 3.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pex14_N PF04695.13 KOS20328.1 - 0.89 10.2 8.9 2.4 8.8 4.2 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Glyco_tran_28_C PF04101.16 KOS20329.1 - 3.8e-18 66.0 0.0 2.2e-17 63.6 0.0 1.9 1 1 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 KOS20329.1 - 0.056 12.2 0.0 0.074 11.8 0.0 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase WD40 PF00400.32 KOS20330.1 - 4.6e-29 100.0 24.3 5.3e-06 27.1 0.1 9.8 10 1 0 10 10 10 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20330.1 - 4.3e-16 59.0 2.3 0.0002 21.6 0.1 6.4 4 3 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOS20330.1 - 0.0011 18.8 4.1 2.3 8.2 0.0 5.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 KOS20330.1 - 0.0044 16.0 0.8 0.92 8.4 0.0 3.3 3 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 KOS20330.1 - 0.048 12.7 0.0 0.28 10.2 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region Sec3_C PF09763.9 KOS20331.1 - 0.084 11.2 1.0 0.097 11.0 1.0 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 SPX PF03105.19 KOS20331.1 - 0.23 11.4 6.5 0.22 11.4 6.5 1.1 1 0 0 1 1 1 0 SPX domain CFEM PF05730.11 KOS20331.1 - 0.27 11.3 11.1 0.54 10.4 10.9 1.7 1 1 0 1 1 1 0 CFEM domain Senescence_reg PF04520.13 KOS20331.1 - 0.39 11.5 8.3 0.58 11.0 8.3 1.3 1 0 0 1 1 1 0 Senescence regulator Macoilin PF09726.9 KOS20331.1 - 0.48 8.9 9.4 0.48 8.9 9.4 1.1 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 KOS20331.1 - 1.2 7.9 8.7 1.3 7.8 8.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain RAP1 PF07218.11 KOS20331.1 - 2.5 6.3 18.3 2.9 6.0 18.3 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) MCLC PF05934.11 KOS20331.1 - 3.6 6.2 7.2 3.9 6.1 7.2 1.1 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) DUF4551 PF15087.6 KOS20331.1 - 3.9 6.2 11.3 4.9 5.9 11.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Alba PF01918.21 KOS20333.1 - 0.035 13.9 0.0 0.06 13.2 0.0 1.3 1 0 0 1 1 1 0 Alba DUF202 PF02656.15 KOS20334.1 - 7.8e-16 58.3 4.8 7.8e-16 58.3 4.8 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF202) DUF1430 PF07242.11 KOS20334.1 - 0.071 13.4 1.3 3 8.1 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1430) Tctex-1 PF03645.13 KOS20335.1 - 2e-39 133.9 0.0 2.4e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family Fringe PF02434.16 KOS20337.1 - 0.012 15.1 0.8 0.19 11.2 0.8 2.4 1 1 0 1 1 1 0 Fringe-like DUF1664 PF07889.12 KOS20338.1 - 0.02 14.9 0.1 0.023 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ABC_tran_CTD PF16326.5 KOS20338.1 - 0.031 14.5 1.7 2.1 8.7 0.1 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain TolA_bind_tri PF16331.5 KOS20338.1 - 0.04 14.0 0.2 0.053 13.6 0.2 1.2 1 0 0 1 1 1 0 TolA binding protein trimerisation EzrA PF06160.12 KOS20339.1 - 0.022 12.9 6.2 0.028 12.6 6.2 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Herpes_UL6 PF01763.16 KOS20339.1 - 0.023 13.3 3.6 0.028 13.0 3.6 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Seryl_tRNA_N PF02403.22 KOS20339.1 - 0.023 14.9 9.6 0.05 13.8 9.6 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain PspB PF06667.12 KOS20339.1 - 0.27 11.3 11.4 0.56 10.3 3.3 2.6 1 1 1 2 2 2 0 Phage shock protein B DUF1664 PF07889.12 KOS20339.1 - 0.28 11.2 4.3 0.39 10.7 3.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3552 PF12072.8 KOS20339.1 - 0.31 10.4 17.6 0.55 9.6 17.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) FUSC PF04632.12 KOS20339.1 - 1 7.8 11.4 1.4 7.3 11.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF724 PF05266.14 KOS20339.1 - 1.8 8.4 11.1 1.9 8.2 10.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF724) CLZ PF16526.5 KOS20339.1 - 2.1 8.8 13.6 0.76 10.2 1.3 3.2 2 1 2 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Allexi_40kDa PF05549.11 KOS20339.1 - 2.4 7.6 5.5 3.8 6.9 3.9 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein Surfac_D-trimer PF09006.11 KOS20339.1 - 2.5 8.1 6.1 10 6.1 0.3 3.6 4 0 0 4 4 4 0 Lung surfactant protein D coiled-coil trimerisation APG6_N PF17675.1 KOS20339.1 - 2.9 8.4 19.3 1.1 9.8 16.7 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4407 PF14362.6 KOS20339.1 - 3.6 6.9 8.9 4.5 6.5 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 KOS20339.1 - 4.4 7.7 17.4 4.2 7.8 4.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) XhlA PF10779.9 KOS20339.1 - 5.1 7.4 5.6 3.7 7.8 3.3 2.0 2 1 0 2 2 2 0 Haemolysin XhlA V_ATPase_I PF01496.19 KOS20339.1 - 6.5 4.5 6.7 7.8 4.3 6.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 KOS20339.1 - 6.7 6.9 21.7 1.9 8.7 8.8 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 CENP-Q PF13094.6 KOS20339.1 - 9.6 6.4 17.0 15 5.7 17.0 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Med3 PF11593.8 KOS20340.1 - 0.0051 16.0 8.5 0.0051 16.0 8.5 1.9 2 0 0 2 2 2 1 Mediator complex subunit 3 fungal TFIIA PF03153.13 KOS20340.1 - 0.43 10.5 12.1 0.51 10.3 12.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp12 PF04003.12 KOS20340.1 - 0.68 10.3 6.0 0.34 11.2 1.3 2.4 2 1 0 2 2 2 0 Dip2/Utp12 Family Spore_coat_CotO PF14153.6 KOS20340.1 - 1.4 8.8 11.4 2.3 8.1 11.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO Cyclin_N PF00134.23 KOS20341.1 - 3.2e-08 33.4 0.0 7.1e-08 32.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain UPF0121 PF03661.13 KOS20342.1 - 4.2e-27 95.1 4.0 5e-27 94.9 4.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF1996 PF09362.10 KOS20343.1 - 3.5e-24 86.1 0.4 6.4e-24 85.2 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1996) DUF563 PF04577.14 KOS20344.1 - 9.1e-34 117.4 0.0 1.2e-33 117.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF563) BSP_II PF05432.11 KOS20344.1 - 0.08 12.6 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Retinal PF15449.6 KOS20344.1 - 7.5 4.2 8.3 11 3.7 8.3 1.1 1 0 0 1 1 1 0 Retinal protein VSP PF03302.13 KOS20345.1 - 3.5e-07 29.4 0.5 6.2e-07 28.6 0.5 1.4 1 0 0 1 1 1 1 Giardia variant-specific surface protein DUF4381 PF14316.6 KOS20345.1 - 0.032 14.5 0.7 0.084 13.1 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) TraL PF07178.11 KOS20345.1 - 0.032 14.7 0.0 0.065 13.7 0.0 1.4 1 0 0 1 1 1 0 TraL protein Serglycin PF04360.12 KOS20345.1 - 0.14 12.1 0.2 0.23 11.4 0.2 1.3 1 0 0 1 1 1 0 Serglycin DUF4588 PF15251.6 KOS20346.1 - 1.2e-07 31.7 0.2 1.8e-07 31.2 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4588) SNF2_N PF00176.23 KOS20347.1 - 1.4e-74 250.9 0.0 2.7e-74 250.0 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 KOS20347.1 - 1.1e-42 144.7 2.5 2.4e-42 143.5 1.3 2.3 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 KOS20347.1 - 1.2e-35 122.6 4.4 1.2e-35 122.6 4.4 3.7 3 0 0 3 3 3 1 HAND Helicase_C PF00271.31 KOS20347.1 - 8.3e-19 68.0 0.2 3.1e-18 66.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS20347.1 - 1.1e-09 38.5 0.0 4.8e-09 36.4 0.0 2.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOS20347.1 - 9.4e-06 25.0 0.0 7.3e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 KOS20347.1 - 0.00049 20.2 0.0 0.65 10.2 0.0 2.9 2 0 0 2 2 2 2 Myb-like DNA-binding domain DEAD PF00270.29 KOS20347.1 - 0.0033 17.2 0.0 0.0081 15.9 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 KOS20347.1 - 0.0039 16.9 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF1086 PF06461.11 KOS20347.1 - 0.047 13.5 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) Atrophin-1 PF03154.15 KOS20348.1 - 1.1 7.4 13.7 2.1 6.6 13.7 1.4 1 0 0 1 1 1 0 Atrophin-1 family DSPc PF00782.20 KOS20349.1 - 6.6e-11 42.1 0.0 1e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 KOS20349.1 - 0.0022 17.6 0.1 0.012 15.2 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 KOS20349.1 - 0.0036 17.3 0.1 0.0057 16.6 0.1 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 KOS20349.1 - 0.062 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate p450 PF00067.22 KOS20350.1 - 4.5e-45 154.3 0.0 2.2e-33 115.7 0.0 2.5 2 1 0 2 2 2 2 Cytochrome P450 WD40 PF00400.32 KOS20352.1 - 2.2e-24 85.2 2.1 1.6e-07 31.9 0.1 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20352.1 - 5.8e-15 55.4 0.0 0.0056 17.0 0.1 4.9 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS20352.1 - 0.0018 18.2 0.1 3.5 7.5 0.0 3.4 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 KOS20352.1 - 0.0022 16.7 0.0 0.008 14.9 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 KOS20352.1 - 0.034 13.7 0.1 0.69 9.4 0.0 2.2 2 0 0 2 2 2 0 PQQ-like domain Coatomer_WDAD PF04053.14 KOS20352.1 - 0.049 12.7 0.0 0.47 9.5 0.0 2.0 1 1 0 2 2 2 0 Coatomer WD associated region Ge1_WD40 PF16529.5 KOS20352.1 - 0.08 11.9 0.6 7.1 5.5 0.0 2.4 2 1 0 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 KOS20352.1 - 0.13 11.2 0.2 6.5 5.6 0.0 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 KOS20352.1 - 0.14 11.4 0.0 0.52 9.6 0.0 2.0 2 1 0 2 2 2 0 WD40-like domain FTHFS PF01268.19 KOS20353.1 - 2.1e-254 844.9 0.0 3.2e-254 844.3 0.0 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 KOS20353.1 - 1.1e-66 223.1 1.5 1.1e-66 223.1 1.5 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 KOS20353.1 - 1.4e-28 99.4 0.1 2.8e-28 98.5 0.1 1.5 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Helicase_C_4 PF13871.6 KOS20353.1 - 0.15 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue Oxidored_q6 PF01058.22 KOS20354.1 - 4.3e-22 78.4 0.0 5.8e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit HECT PF00632.25 KOS20355.1 - 5.7e-97 324.9 0.0 7.4e-97 324.5 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 KOS20355.1 - 3.7e-23 81.3 16.4 2.8e-12 46.5 6.2 3.0 3 0 0 3 3 3 2 WW domain Ion_trans PF00520.31 KOS20356.1 - 0.00011 21.5 2.8 0.00016 21.0 2.8 1.1 1 0 0 1 1 1 1 Ion transport protein CCDC106 PF15794.5 KOS20356.1 - 0.0066 16.2 0.1 0.0086 15.8 0.1 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 106 bZIP_1 PF00170.21 KOS20356.1 - 0.045 13.9 0.1 0.093 12.8 0.1 1.4 1 0 0 1 1 1 0 bZIP transcription factor UPF0242 PF06785.11 KOS20356.1 - 0.061 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HAP1_N PF04849.13 KOS20356.1 - 0.067 12.4 0.2 0.088 12.0 0.2 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region ThrE PF06738.12 KOS20356.1 - 5.2 6.4 11.0 2.4 7.4 8.7 1.6 1 1 0 1 1 1 0 Putative threonine/serine exporter DSPc PF00782.20 KOS20357.1 - 1.4e-11 44.3 0.1 7.9e-10 38.7 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 KOS20357.1 - 0.0056 17.0 0.0 0.013 15.8 0.0 1.6 1 1 0 1 1 1 1 Rit1 DUSP-like domain tRNA_bind_2 PF13725.6 KOS20357.1 - 0.044 13.5 0.1 0.082 12.6 0.1 1.4 1 0 0 1 1 1 0 Possible tRNA binding domain MP PF01107.18 KOS20357.1 - 0.053 13.1 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 Viral movement protein (MP) SUV3_C PF12513.8 KOS20358.1 - 4e-14 52.3 0.2 1.3e-13 50.6 0.2 2.0 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Suv3_C_1 PF18147.1 KOS20358.1 - 1.5e-11 44.0 0.6 2.8e-11 43.1 0.6 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 Helicase_C PF00271.31 KOS20358.1 - 9.4e-10 38.8 0.1 2.3e-09 37.6 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain FMO-like PF00743.19 KOS20359.1 - 2.2e-30 105.6 0.0 5.9e-14 51.4 0.0 3.4 3 1 0 3 3 3 3 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 KOS20359.1 - 3.8e-15 55.9 0.0 1.6e-14 53.9 0.0 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS20359.1 - 1.1e-09 38.0 0.0 0.00014 21.2 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS20359.1 - 2e-09 37.6 0.9 0.00048 20.2 0.0 3.7 3 0 0 3 3 3 2 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOS20359.1 - 5e-09 35.8 0.2 6.8e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOS20359.1 - 8.6e-09 35.5 0.4 1.3e-07 31.7 0.0 3.1 3 1 1 4 4 3 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS20359.1 - 2.5e-08 33.9 6.5 7.8e-06 25.7 0.6 2.9 3 0 0 3 3 3 2 FAD dependent oxidoreductase Amino_oxidase PF01593.24 KOS20359.1 - 3.9e-07 29.7 0.0 0.0028 17.0 0.0 2.7 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 KOS20359.1 - 2.4e-06 28.0 3.6 0.00015 22.2 0.1 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS20359.1 - 1e-05 24.9 0.2 0.00042 19.7 0.1 2.3 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 KOS20359.1 - 2.1e-05 24.6 0.1 0.034 14.2 0.0 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase Thi4 PF01946.17 KOS20359.1 - 2.9e-05 23.4 2.0 3e-05 23.4 0.1 1.8 2 0 0 2 2 2 1 Thi4 family FAD_oxidored PF12831.7 KOS20359.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS20359.1 - 0.00045 19.4 0.0 0.001 18.2 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain GIDA PF01134.22 KOS20359.1 - 0.0008 18.6 0.0 0.0018 17.4 0.1 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 KOS20359.1 - 0.0012 17.6 0.3 0.0023 16.7 0.3 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 KOS20359.1 - 0.0014 17.9 0.5 0.0037 16.6 0.2 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 KOS20359.1 - 0.0053 17.2 0.1 2.5 8.6 0.1 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 KOS20359.1 - 0.0057 16.6 0.1 0.0057 16.6 0.1 1.6 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 KOS20359.1 - 0.067 12.2 0.4 0.94 8.4 0.0 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_2 PF03446.15 KOS20359.1 - 0.11 12.7 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase MCRA PF06100.11 KOS20359.1 - 0.14 10.9 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 MCRA family Tyrosinase PF00264.20 KOS20360.1 - 2.7e-13 50.7 2.6 2.6e-12 47.5 0.7 2.0 1 1 1 2 2 2 1 Common central domain of tyrosinase DUF5643 PF18705.1 KOS20360.1 - 0.068 13.2 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5643) DUF2235 PF09994.9 KOS20361.1 - 4.9e-102 341.2 0.5 6.8e-102 340.7 0.5 1.2 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) Palm_thioest PF02089.15 KOS20361.1 - 0.097 12.5 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase ECH_1 PF00378.20 KOS20362.1 - 5.3e-55 186.4 0.0 1.5e-41 142.4 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS20362.1 - 4.1e-27 95.6 0.0 2.6e-26 92.9 0.0 2.1 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase Ribonuclease_3 PF00636.26 KOS20364.1 - 3.6e-40 136.8 1.1 3.4e-21 75.8 0.0 3.6 3 0 0 3 3 3 2 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KOS20364.1 - 4.6e-22 78.5 0.0 4.6e-10 39.7 0.0 3.7 3 0 0 3 3 3 3 Ribonuclease-III-like Dicer_dimer PF03368.14 KOS20364.1 - 9.1e-20 70.6 0.3 1.2e-17 63.8 0.2 2.8 2 0 0 2 2 2 1 Dicer dimerisation domain Helicase_C PF00271.31 KOS20364.1 - 8.2e-17 61.6 0.1 3.1e-16 59.7 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS20364.1 - 4.1e-13 49.7 0.0 1.5e-12 47.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 KOS20364.1 - 6.8e-11 42.2 0.0 1.3e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 KOS20364.1 - 0.0062 15.8 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_22 PF13401.6 KOS20364.1 - 0.023 15.0 0.1 0.16 12.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KOS20365.1 - 1.9e-24 86.6 0.4 3.7e-15 56.4 0.0 2.7 1 1 1 2 2 2 2 Dynamin family Dynamin_M PF01031.20 KOS20365.1 - 7.9e-21 74.5 0.0 5.6e-20 71.7 0.0 2.1 2 0 0 2 2 2 1 Dynamin central region MMR_HSR1 PF01926.23 KOS20365.1 - 1.3e-05 25.2 0.0 3.1e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GED PF02212.18 KOS20365.1 - 0.00016 21.7 0.5 0.013 15.6 0.0 3.2 3 0 0 3 3 3 1 Dynamin GTPase effector domain GTP_EFTU PF00009.27 KOS20365.1 - 0.0027 17.3 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Roc PF08477.13 KOS20365.1 - 0.01 16.1 0.0 0.03 14.5 0.0 1.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_15 PF13175.6 KOS20365.1 - 0.03 14.1 0.0 0.086 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain Dmrt1 PF12374.8 KOS20365.1 - 0.056 13.9 0.2 0.2 12.2 0.0 2.0 2 0 0 2 2 2 0 Double-sex mab3 related transcription factor 1 FeoB_N PF02421.18 KOS20365.1 - 0.085 12.4 0.1 1.2 8.6 0.1 2.2 1 1 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.22 KOS20365.1 - 0.086 12.4 0.0 0.19 11.3 0.0 1.6 1 0 0 1 1 1 0 Ras family THOC2_N PF16134.5 KOS20366.1 - 7.8e-242 804.4 0.0 1.5e-241 803.5 0.0 1.5 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 KOS20366.1 - 2.3e-95 319.3 0.4 4e-95 318.5 0.4 1.4 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 KOS20366.1 - 2.4e-28 98.0 0.1 6.9e-28 96.5 0.1 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit GATase PF00117.28 KOS20370.1 - 6.9e-10 39.0 0.0 8.9e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I SOG2 PF10428.9 KOS20371.1 - 0.55 9.4 14.5 0.62 9.2 14.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein SPESP1 PF15754.5 KOS20371.1 - 1 8.5 7.3 1.2 8.2 7.3 1.0 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Med13_C PF06333.12 KOS20371.1 - 1.8 7.7 10.8 2.3 7.4 10.8 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain CDC27 PF09507.10 KOS20371.1 - 8.3 5.7 9.2 9.6 5.5 9.2 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Fungal_trans_2 PF11951.8 KOS20372.1 - 0.013 14.4 0.2 0.02 13.7 0.2 1.2 1 0 0 1 1 1 0 Fungal specific transcription factor domain Fungal_trans PF04082.18 KOS20373.1 - 7.6e-09 35.0 3.5 0.00014 21.0 0.8 2.3 1 1 1 2 2 2 2 Fungal specific transcription factor domain RabGAP-TBC PF00566.18 KOS20374.1 - 2e-50 171.4 0.0 3.4e-50 170.7 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Chorion_2 PF03964.15 KOS20374.1 - 3 8.7 10.3 0.21 12.4 2.0 2.3 2 0 0 2 2 2 0 Chorion family 2 zf-RING_2 PF13639.6 KOS20375.1 - 5.4e-09 36.2 8.4 1.2e-08 35.1 8.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-ANAPC11 PF12861.7 KOS20375.1 - 9e-06 25.7 3.6 0.00015 21.8 3.2 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger FANCL_C PF11793.8 KOS20375.1 - 1.2e-05 25.4 7.9 3.4e-05 23.9 7.9 1.8 1 1 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 KOS20375.1 - 2e-05 24.8 7.6 6.2e-05 23.2 7.1 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 KOS20375.1 - 0.00095 18.7 4.6 0.0022 17.6 4.6 1.5 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KOS20375.1 - 0.0022 18.1 7.3 0.005 16.9 7.3 1.7 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.25 KOS20375.1 - 0.0033 17.3 9.0 0.008 16.0 9.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS20375.1 - 0.022 14.6 7.8 0.048 13.5 7.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS20375.1 - 0.028 14.3 5.6 0.057 13.3 5.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.22 KOS20375.1 - 0.03 14.2 6.3 0.018 14.9 3.6 2.0 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 KOS20375.1 - 0.035 14.4 7.7 0.072 13.4 7.7 1.6 1 0 0 1 1 1 0 RING-like domain Prok-RING_4 PF14447.6 KOS20375.1 - 1.2 9.1 6.8 5.1 7.0 6.9 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_9 PF13901.6 KOS20375.1 - 1.9 8.4 7.1 3.6 7.5 7.1 1.4 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon PHD PF00628.29 KOS20375.1 - 1.9 8.4 6.6 3.7 7.5 6.6 1.5 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KOS20375.1 - 2.9 8.1 4.7 6.5 6.9 3.2 2.2 2 0 0 2 2 2 0 KIAA1045 RING finger zf-RING_5 PF14634.6 KOS20375.1 - 4.4 7.4 8.4 8 6.5 8.4 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.6 KOS20375.1 - 6.9 6.5 7.5 2.5e+02 1.5 7.5 2.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain PS_Dcarbxylase PF02666.15 KOS20376.1 - 3.4e-55 186.7 0.0 5e-55 186.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 KOS20376.1 - 1.9e-27 95.5 0.0 2.1e-16 60.1 0.0 2.4 2 0 0 2 2 2 2 C2 domain EF-hand_1 PF00036.32 KOS20376.1 - 0.0031 17.0 0.0 0.011 15.3 0.0 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 KOS20376.1 - 0.013 15.3 0.2 0.093 12.6 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_7 PF13499.6 KOS20376.1 - 0.037 14.5 1.1 0.23 11.9 0.3 2.6 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 KOS20376.1 - 0.069 12.7 0.1 0.37 10.4 0.0 2.3 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOS20376.1 - 0.26 11.3 0.0 0.26 11.3 0.0 3.0 4 0 0 4 4 4 0 EF-hand domain ICL PF00463.21 KOS20378.1 - 6.5e-271 899.4 0.0 5.3e-270 896.4 0.0 1.9 1 1 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 KOS20378.1 - 2.8e-11 43.3 0.0 3.6e-10 39.7 0.0 2.2 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Pkinase PF00069.25 KOS20379.1 - 2.8e-73 246.5 0.0 3.8e-73 246.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20379.1 - 4.2e-38 131.1 0.0 6.8e-38 130.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase AdenylateSensor PF16579.5 KOS20379.1 - 1.1e-18 67.8 0.0 5.8e-10 39.7 0.0 3.2 3 0 0 3 3 3 2 Adenylate sensor of SNF1-like protein kinase UBA_2 PF08587.11 KOS20379.1 - 2e-14 53.4 0.2 4.1e-14 52.4 0.2 1.6 1 0 0 1 1 1 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 KOS20379.1 - 2.7e-06 26.9 0.0 5.4e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 KOS20379.1 - 0.001 18.7 0.0 0.0021 17.7 0.0 1.5 1 0 0 1 1 1 1 RIO1 family Haspin_kinase PF12330.8 KOS20379.1 - 0.0016 17.4 0.1 0.0052 15.8 0.2 1.8 2 1 0 2 2 2 1 Haspin like kinase domain YukC PF10140.9 KOS20379.1 - 0.0063 15.4 0.0 0.0093 14.8 0.0 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC APH PF01636.23 KOS20379.1 - 0.13 12.2 0.2 0.42 10.5 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family COX6B PF02297.17 KOS20380.1 - 3.1e-17 62.6 5.5 3.6e-17 62.4 5.5 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 KOS20380.1 - 0.02 14.9 1.7 0.032 14.2 1.7 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, APOBEC_C PF05240.14 KOS20380.1 - 0.036 14.0 0.4 0.054 13.5 0.4 1.5 1 0 0 1 1 1 0 APOBEC-like C-terminal domain ketoacyl-synt PF00109.26 KOS20380.1 - 0.14 11.7 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain B12D PF06522.11 KOS20381.1 - 0.00037 20.2 0.0 0.00056 19.6 0.0 1.3 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit S10_plectin PF03501.15 KOS20382.1 - 5.2e-41 138.6 0.1 6.3e-41 138.4 0.1 1.1 1 0 0 1 1 1 1 Plectin/S10 domain Sde2_N_Ubi PF13019.6 KOS20383.1 - 9.8e-67 223.9 0.1 1.4e-66 223.3 0.1 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Serglycin PF04360.12 KOS20383.1 - 0.0041 17.1 3.8 0.0086 16.0 3.8 1.5 1 0 0 1 1 1 1 Serglycin PI3K_1B_p101 PF10486.9 KOS20383.1 - 4.5 4.9 4.7 5.9 4.5 4.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Gp_dh_C PF02800.20 KOS20384.1 - 3.2e-72 241.3 0.1 4.7e-72 240.7 0.1 1.3 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 KOS20384.1 - 3.1e-37 127.0 0.2 7.9e-37 125.7 0.1 1.7 2 0 0 2 2 2 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 KOS20384.1 - 0.06 13.5 0.5 0.19 11.9 0.5 2.0 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 KOS20384.1 - 0.088 12.2 0.1 0.21 11.0 0.0 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CobT PF06213.12 KOS20385.1 - 0.13 11.6 19.1 0.22 10.9 19.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 KOS20385.1 - 0.2 9.6 7.4 0.22 9.4 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RAB3GAP2_C PF14656.6 KOS20385.1 - 0.27 9.4 5.9 0.32 9.2 5.9 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus DUF4637 PF15470.6 KOS20385.1 - 0.37 10.5 13.0 0.65 9.7 13.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Paf1 PF03985.13 KOS20385.1 - 0.46 9.4 21.8 0.68 8.9 21.8 1.2 1 0 0 1 1 1 0 Paf1 MAT1 PF06391.13 KOS20385.1 - 0.78 9.5 24.7 0.17 11.7 21.1 1.7 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Presenilin PF01080.17 KOS20385.1 - 0.83 8.4 13.9 1.1 7.9 13.9 1.1 1 0 0 1 1 1 0 Presenilin VIR_N PF15912.5 KOS20385.1 - 0.89 9.1 18.4 1.4 8.4 18.4 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4820 PF16091.5 KOS20385.1 - 1.1 8.6 11.8 1.7 7.9 10.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) CDC45 PF02724.14 KOS20385.1 - 1.5 7.0 13.0 2 6.6 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein AIF_C PF14721.6 KOS20385.1 - 1.7 9.0 10.1 0.33 11.3 6.2 1.7 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4407 PF14362.6 KOS20385.1 - 1.8 7.9 5.1 2 7.7 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDRGK PF09756.9 KOS20385.1 - 2.3 7.8 23.0 4.3 6.9 23.0 1.4 1 0 0 1 1 1 0 DDRGK domain Pinin_SDK_memA PF04696.13 KOS20385.1 - 3 7.9 26.8 4.9 7.2 22.7 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region DNA_pol_phi PF04931.13 KOS20385.1 - 3 5.8 15.3 4.1 5.4 15.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Serinc PF03348.15 KOS20385.1 - 3.3 6.5 4.7 3.7 6.4 4.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) NOA36 PF06524.12 KOS20385.1 - 3.6 6.8 11.2 4.9 6.4 11.2 1.2 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 KOS20385.1 - 3.9 6.6 6.4 5.1 6.2 6.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Suf PF05843.14 KOS20385.1 - 4.7 7.1 14.2 7.3 6.5 14.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) MDM10 PF12519.8 KOS20385.1 - 5 5.9 7.0 5.7 5.7 7.0 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF4551 PF15087.6 KOS20385.1 - 6 5.6 14.0 6.7 5.4 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Pox_Ag35 PF03286.14 KOS20385.1 - 6.8 6.4 18.1 9.9 5.9 18.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.16 KOS20385.1 - 6.9 5.8 11.2 13 4.9 11.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF5427 PF10310.9 KOS20385.1 - 7 5.5 23.1 9.3 5.1 23.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Hid1 PF12722.7 KOS20385.1 - 7.8 4.5 12.9 8.8 4.3 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRM_1 PF00076.22 KOS20386.1 - 2.5e-16 59.3 0.0 3.7e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS20386.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif BLOC1_2 PF10046.9 KOS20386.1 - 0.034 14.5 1.7 0.051 13.9 1.7 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 KOS20386.1 - 0.041 14.4 0.4 0.077 13.5 0.4 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein V_ATPase_I PF01496.19 KOS20386.1 - 0.053 11.5 1.3 0.063 11.2 1.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PRKG1_interact PF15898.5 KOS20386.1 - 0.076 13.9 3.9 0.11 13.4 3.9 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Spc7 PF08317.11 KOS20386.1 - 0.099 11.5 4.1 0.14 11.1 4.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein EMP24_GP25L PF01105.24 KOS20386.1 - 0.17 11.8 0.8 0.24 11.3 0.8 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD T2SSM PF04612.12 KOS20386.1 - 0.21 11.6 1.9 0.33 11.0 1.9 1.2 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M DivIC PF04977.15 KOS20386.1 - 0.22 11.3 6.7 0.34 10.7 6.7 1.2 1 0 0 1 1 1 0 Septum formation initiator GRP PF07172.11 KOS20386.1 - 2.5 8.9 16.4 0.052 14.2 8.8 2.0 2 1 0 2 2 2 0 Glycine rich protein family Lum_binding PF00677.17 KOS20387.1 - 3.1e-46 155.3 0.6 1.3e-22 79.6 0.5 2.1 2 0 0 2 2 2 2 Lumazine binding domain HABP4_PAI-RBP1 PF04774.15 KOS20388.1 - 0.0017 19.2 0.5 0.0025 18.6 0.5 1.4 1 1 0 1 1 1 1 Hyaluronan / mRNA binding family SH2_2 PF14633.6 KOS20389.1 - 1.4e-85 286.1 0.0 4e-85 284.6 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HTH_44 PF14641.6 KOS20389.1 - 1.3e-39 135.1 1.1 4.4e-39 133.5 1.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 HHH_7 PF14635.6 KOS20389.1 - 4.7e-32 110.4 0.0 1.2e-31 109.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif YqgF PF14639.6 KOS20389.1 - 7.8e-30 103.6 0.0 3e-29 101.7 0.0 2.1 1 0 0 1 1 1 1 Holliday-junction resolvase-like of SPT6 SPT6_acidic PF14632.6 KOS20389.1 - 4.5e-22 78.4 23.3 4.5e-22 78.4 23.3 7.1 3 1 3 6 6 4 1 Acidic N-terminal SPT6 HHH_9 PF17674.1 KOS20389.1 - 6.3e-07 30.2 1.1 1.5e-05 25.8 1.1 3.4 1 1 0 1 1 1 1 HHH domain SH2 PF00017.24 KOS20389.1 - 8.6e-06 25.8 0.0 2.3e-05 24.4 0.0 1.8 1 0 0 1 1 1 1 SH2 domain HHH_3 PF12836.7 KOS20389.1 - 3e-05 24.2 0.0 0.0002 21.5 0.0 2.5 3 0 0 3 3 3 1 Helix-hairpin-helix motif S1 PF00575.23 KOS20389.1 - 6.4e-05 23.2 0.1 0.00015 22.0 0.1 1.6 1 0 0 1 1 1 1 S1 RNA binding domain PSD4 PF07631.11 KOS20389.1 - 0.11 13.1 0.9 9.7 6.7 0.0 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1592) Tex_YqgF PF16921.5 KOS20389.1 - 0.14 12.6 0.0 1.2 9.6 0.0 2.4 2 1 0 2 2 2 0 Tex protein YqgF-like domain Perilipin PF03036.16 KOS20390.1 - 0.0062 15.6 0.0 0.0078 15.3 0.0 1.3 1 0 0 1 1 1 1 Perilipin family PET10 PF17316.2 KOS20390.1 - 0.14 11.6 0.5 0.54 9.7 0.0 1.9 1 1 0 2 2 2 0 Petite colonies protein 10 Pkinase_fungal PF17667.1 KOS20391.1 - 0.0042 15.9 0.0 0.0064 15.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS20391.1 - 0.32 10.9 6.3 1.5 8.7 6.3 2.1 1 1 0 1 1 1 0 Phosphotransferase enzyme family PBP1_TM PF14812.6 KOS20391.1 - 2.2 8.7 7.3 1.1 9.7 4.0 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pirin PF02678.16 KOS20392.1 - 1e-29 102.7 0.0 1.8e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Pirin Pirin_C PF05726.13 KOS20392.1 - 2.3e-25 89.0 0.0 6.2e-25 87.6 0.0 1.7 2 0 0 2 2 2 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 KOS20392.1 - 2e-06 27.4 1.5 0.00014 21.5 1.6 2.4 2 0 0 2 2 2 2 Cupin domain CFEM PF05730.11 KOS20393.1 - 1.5e-08 34.6 5.4 2.8e-08 33.7 5.4 1.5 1 0 0 1 1 1 1 CFEM domain Ribonuc_red_lgC PF02867.15 KOS20394.1 - 4.7e-191 635.9 0.0 6e-191 635.5 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 KOS20394.1 - 4.6e-24 84.2 0.0 1.4e-23 82.7 0.0 1.9 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 KOS20394.1 - 4.1e-17 62.5 0.0 1e-16 61.3 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain Pox_Ag35 PF03286.14 KOS20394.1 - 3.3 7.4 9.3 6 6.6 9.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TatD_DNase PF01026.21 KOS20395.1 - 3.2e-46 157.8 0.0 1.3e-45 155.7 0.0 1.7 1 1 0 1 1 1 1 TatD related DNase Coilin_N PF15862.5 KOS20395.1 - 0.027 14.3 0.0 0.046 13.5 0.0 1.3 1 0 0 1 1 1 0 Coilin N-terminus Amidohydro_2 PF04909.14 KOS20395.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Amidohydrolase CENP-N PF05238.13 KOS20396.1 - 2.7e-125 418.9 0.0 3.1e-125 418.8 0.0 1.0 1 0 0 1 1 1 1 Kinetochore protein CHL4 like GP67 PF17634.2 KOS20396.1 - 0.0031 17.9 0.5 0.0031 17.9 0.5 1.9 2 0 0 2 2 2 1 Gene product 67 bZIP_2 PF07716.15 KOS20397.1 - 7.4e-13 48.4 11.7 1.2e-12 47.7 11.7 1.3 1 0 0 1 1 1 1 Basic region leucine zipper LCD1 PF09798.9 KOS20397.1 - 0.0024 16.5 0.2 0.0024 16.5 0.2 1.1 1 0 0 1 1 1 1 DNA damage checkpoint protein bZIP_1 PF00170.21 KOS20397.1 - 0.0051 16.9 17.5 0.0097 16.0 11.8 1.7 1 1 1 2 2 2 2 bZIP transcription factor GIT_CC PF16559.5 KOS20397.1 - 0.012 15.5 1.6 0.032 14.1 1.6 1.6 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 KOS20397.1 - 0.024 14.9 0.3 0.05 13.9 0.3 1.5 1 0 0 1 1 1 0 TSC-22/dip/bun family Fib_alpha PF08702.10 KOS20397.1 - 0.033 14.4 1.9 0.055 13.7 1.9 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family XhlA PF10779.9 KOS20397.1 - 0.079 13.2 2.9 0.18 12.1 2.9 1.6 1 0 0 1 1 1 0 Haemolysin XhlA YabA PF06156.13 KOS20397.1 - 1.1 9.9 3.7 1.4 9.6 2.5 1.8 1 1 1 2 2 2 0 Initiation control protein YabA Matrilin_ccoil PF10393.9 KOS20397.1 - 1.9 8.4 4.0 0.6 10.0 0.6 1.9 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Seryl_tRNA_N PF02403.22 KOS20397.1 - 2.1 8.6 10.5 1.3 9.2 7.9 1.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain M20_dimer PF07687.14 KOS20398.1 - 0.028 14.3 0.1 0.046 13.6 0.1 1.6 1 1 0 1 1 1 0 Peptidase dimerisation domain Ank_2 PF12796.7 KOS20399.1 - 1.4e-09 38.4 0.0 5.9e-09 36.4 0.0 1.9 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOS20399.1 - 1.1e-06 28.8 0.0 0.064 13.7 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 KOS20399.1 - 7.6e-06 26.4 0.0 8.6e-05 23.0 0.0 2.5 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS20399.1 - 3.4e-05 23.9 0.0 0.18 12.4 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 KOS20399.1 - 0.0014 18.9 0.0 0.083 13.2 0.0 2.8 2 2 0 2 2 2 1 Ankyrin repeats (many copies) peroxidase PF00141.23 KOS20400.1 - 1.4e-82 276.8 0.0 2.6e-45 154.9 0.0 2.3 2 1 0 2 2 2 2 Peroxidase ScsC_N PF18312.1 KOS20400.1 - 0.99 9.3 3.9 0.82 9.5 1.3 2.2 2 0 0 2 2 2 0 Copper resistance protein ScsC N-terminal domain Glyoxalase PF00903.25 KOS20401.1 - 2.9e-08 34.0 0.4 4.8e-08 33.2 0.4 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KOS20401.1 - 1.6e-06 28.9 0.1 1.8e-06 28.7 0.1 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain MFS_1 PF07690.16 KOS20402.1 - 1.1e-24 87.0 51.9 5.7e-22 78.1 53.7 3.0 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS20402.1 - 8.5e-16 57.8 15.3 8.5e-16 57.8 15.3 3.4 1 1 1 3 3 3 1 Sugar (and other) transporter Glyco_hydro_18 PF00704.28 KOS20403.1 - 9.2e-18 65.0 0.8 4.7e-17 62.7 0.8 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CBM_1 PF00734.18 KOS20403.1 - 1.1e-10 41.2 11.6 3.2e-10 39.8 11.6 1.9 1 0 0 1 1 1 1 Fungal cellulose binding domain DEC-1_N PF04625.13 KOS20403.1 - 1.6 7.7 8.2 2.6 7.0 8.2 1.4 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region MFS_1 PF07690.16 KOS20404.1 - 1.5e-44 152.4 35.6 1.6e-43 149.0 13.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Abhydrolase_3 PF07859.13 KOS20405.1 - 5e-54 183.4 0.2 7.1e-54 182.9 0.2 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 KOS20405.1 - 4.1e-09 35.8 0.1 1.8e-08 33.8 0.1 1.8 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 KOS20405.1 - 0.0008 18.9 0.0 0.023 14.2 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOS20405.1 - 0.088 13.4 3.6 0.2 12.2 3.6 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family Sugar_tr PF00083.24 KOS20406.1 - 7.2e-80 269.1 27.5 8.2e-80 268.8 27.5 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS20406.1 - 1.6e-27 96.4 58.0 8.9e-21 74.2 35.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Trp_oprn_chp PF09534.10 KOS20406.1 - 6 6.6 19.5 2.8 7.7 2.3 3.4 3 1 0 3 3 3 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) P5CR_dimer PF14748.6 KOS20407.1 - 7.4e-39 132.2 0.8 1.2e-37 128.3 0.3 2.4 2 0 0 2 2 2 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 KOS20407.1 - 7.4e-17 61.7 0.4 1.4e-16 60.8 0.4 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KOS20407.1 - 0.034 14.2 0.1 0.16 12.0 0.1 2.0 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase PDH PF02153.17 KOS20407.1 - 0.042 12.9 0.1 0.064 12.2 0.1 1.3 1 0 0 1 1 1 0 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 KOS20407.1 - 0.055 13.5 1.4 0.27 11.2 1.4 2.0 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 KOS20407.1 - 0.22 11.2 1.1 0.73 9.5 1.1 1.8 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA E1-E2_ATPase PF00122.20 KOS20408.1 - 2.9e-34 118.2 11.7 1.1e-26 93.4 0.1 3.3 3 0 0 3 3 3 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOS20408.1 - 2.6e-29 102.2 0.6 5.8e-29 101.1 0.0 1.9 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOS20408.1 - 9.2e-23 81.6 0.0 3.6e-18 66.6 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS20408.1 - 7e-15 54.9 0.0 1.3e-14 54.0 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOS20408.1 - 8.4e-13 47.8 0.0 1.6e-12 46.9 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS20408.1 - 1.8e-05 24.6 0.1 0.00069 19.4 0.1 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase DUF2463 PF09591.10 KOS20408.1 - 0.056 13.3 0.5 0.12 12.2 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2463) Aldo_ket_red PF00248.21 KOS20409.1 - 6.2e-39 133.9 0.0 6.8e-28 97.7 0.0 2.1 1 1 1 2 2 2 2 Aldo/keto reductase family P3A PF08727.11 KOS20409.1 - 0.079 12.4 0.1 0.31 10.4 0.2 1.9 2 0 0 2 2 2 0 Poliovirus 3A protein like SAGA-Tad1 PF12767.7 KOS20410.1 - 3.1e-62 210.4 0.0 4.4e-62 209.9 0.0 1.2 1 0 0 1 1 1 1 Transcriptional regulator of RNA polII, SAGA, subunit GCP_C_terminal PF04130.13 KOS20411.1 - 1.2e-97 327.2 0.0 2e-97 326.4 0.0 1.4 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 KOS20411.1 - 1.5e-81 274.4 0.0 4.2e-81 272.9 0.0 1.7 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal PLA2_B PF01735.18 KOS20412.1 - 5.2e-178 592.4 3.4 6.4e-178 592.2 3.4 1.1 1 0 0 1 1 1 1 Lysophospholipase catalytic domain RANK_CRD_2 PF18278.1 KOS20412.1 - 0.49 10.6 3.4 0.39 10.9 1.2 2.0 2 0 0 2 2 2 0 Receptor activator of the NF-KB cysteine-rich repeat domain 2 Mucin PF01456.17 KOS20412.1 - 5.2 7.1 30.3 2.2 8.3 27.6 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF5308 PF17233.2 KOS20413.1 - 3.4e-56 190.0 9.1 7.9e-56 188.8 9.1 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF5308) Presenilin PF01080.17 KOS20413.1 - 0.17 10.6 3.8 0.22 10.2 3.8 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 KOS20413.1 - 0.27 10.0 5.8 0.36 9.6 5.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SPX PF03105.19 KOS20413.1 - 0.42 10.5 12.0 0.52 10.2 12.0 1.3 1 0 0 1 1 1 0 SPX domain CDC45 PF02724.14 KOS20413.1 - 0.45 8.8 5.4 0.55 8.5 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Dynactin PF12455.8 KOS20414.1 - 2.2e-105 352.0 4.9 2.2e-105 352.0 4.9 4.3 4 2 0 4 4 4 1 Dynein associated protein CAP_GLY PF01302.25 KOS20414.1 - 5.5e-22 77.6 0.2 1.2e-21 76.5 0.2 1.6 1 0 0 1 1 1 1 CAP-Gly domain DUF2353 PF09789.9 KOS20414.1 - 0.0021 17.5 27.2 0.0021 17.5 27.2 5.1 2 2 4 6 6 6 1 Uncharacterized coiled-coil protein (DUF2353) GAS PF13851.6 KOS20414.1 - 0.006 16.0 11.1 0.006 16.0 11.1 6.1 4 1 2 6 6 6 4 Growth-arrest specific micro-tubule binding CotJB PF12652.7 KOS20414.1 - 0.82 9.9 3.4 23 5.3 0.5 3.5 2 0 0 2 2 2 0 CotJB protein HOOK PF05622.12 KOS20414.1 - 1.2 7.2 85.2 0.12 10.4 51.9 3.7 2 1 1 3 3 3 0 HOOK protein DUF3138 PF11336.8 KOS20414.1 - 3.7 6.1 8.1 11 4.4 1.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) DASH_Dam1 PF08653.10 KOS20414.1 - 7.2 6.5 12.4 0.85 9.5 0.0 4.7 5 0 0 5 5 5 0 DASH complex subunit Dam1 HMG_box PF00505.19 KOS20415.1 - 6e-21 74.6 2.0 9.8e-21 74.0 2.0 1.4 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 KOS20415.1 - 0.00015 22.3 0.6 0.00038 21.0 0.6 1.7 1 0 0 1 1 1 1 HMG-box domain MATalpha_HMGbox PF04769.12 KOS20415.1 - 0.0053 16.1 0.0 0.0088 15.4 0.0 1.2 1 0 0 1 1 1 1 Mating-type protein MAT alpha 1 HMG-box FXR_C1 PF16096.5 KOS20415.1 - 0.24 11.7 4.5 0.17 12.1 0.6 2.4 2 0 0 2 2 2 0 Fragile X-related 1 protein C-terminal region 2 zf-CCCH_2 PF14608.6 KOS20416.1 - 0.0018 18.7 3.6 0.0018 18.7 3.6 3.6 3 0 0 3 3 3 1 RNA-binding, Nab2-type zinc finger Torus PF16131.5 KOS20416.1 - 0.062 14.0 1.6 0.062 14.0 1.6 2.9 1 1 1 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 KOS20416.1 - 0.91 9.7 14.7 0.77 9.9 0.2 4.1 3 1 1 4 4 4 0 Zinc finger domain SRP19 PF01922.17 KOS20417.1 - 7.6e-32 110.1 0.0 1.2e-31 109.5 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein DUF1179 PF06678.11 KOS20417.1 - 0.081 12.9 0.2 0.16 11.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1179) Cyt-b5 PF00173.28 KOS20418.1 - 1.9e-17 63.2 2.1 2.5e-17 62.8 0.1 2.1 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 KOS20418.1 - 4e-12 46.6 16.2 4e-12 46.6 16.2 1.6 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 KOS20418.1 - 0.14 12.4 0.0 0.27 11.5 0.0 1.4 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region ATP-synt_I PF03899.15 KOS20418.1 - 5.8 7.3 7.2 2 8.8 0.3 2.3 2 0 0 2 2 2 0 ATP synthase I chain SPICE PF15678.5 KOS20419.1 - 0.038 13.4 1.0 0.067 12.5 1.0 1.3 1 0 0 1 1 1 0 Centriole duplication and mitotic chromosome congression Myosin_tail_1 PF01576.19 KOS20419.1 - 0.21 9.4 6.1 0.27 9.0 6.1 1.1 1 0 0 1 1 1 0 Myosin tail PP2C PF00481.21 KOS20420.1 - 5.1e-37 127.9 0.0 6.4e-31 107.9 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 KOS20420.1 - 0.00036 20.2 0.1 0.0024 17.6 0.0 2.1 2 0 0 2 2 2 1 Protein phosphatase 2C YrzK PF17449.2 KOS20420.1 - 0.012 15.9 1.0 0.018 15.3 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized YrzK-like Het-C PF07217.11 KOS20421.1 - 1.5e-281 934.9 0.0 1.8e-281 934.7 0.0 1.0 1 0 0 1 1 1 1 Heterokaryon incompatibility protein Het-C Cu-oxidase_2 PF07731.14 KOS20422.1 - 5.3e-45 152.5 5.8 9.8e-39 132.2 0.2 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 KOS20422.1 - 5.6e-45 152.2 4.2 3.2e-41 140.1 1.3 3.4 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 KOS20422.1 - 4e-37 127.8 1.8 9.8e-34 116.8 0.3 2.5 2 0 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.6 KOS20422.1 - 0.0036 17.4 0.0 10 6.3 0.0 3.6 3 1 0 3 3 3 1 Cupredoxin-like domain FTR1 PF03239.14 KOS20423.1 - 3e-77 259.8 9.0 3.7e-77 259.5 9.0 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Phage_holin_3_6 PF07332.11 KOS20423.1 - 0.042 13.9 1.1 0.042 13.9 1.1 2.7 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III FeoB_associated PF12669.7 KOS20423.1 - 0.87 10.0 8.6 5.1 7.6 0.1 4.4 4 0 0 4 4 4 0 FeoB-associated Cys-rich membrane protein DUF4293 PF14126.6 KOS20423.1 - 1.7 8.9 6.2 0.74 10.0 0.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4293) RRM_1 PF00076.22 KOS20424.1 - 5.6e-35 119.0 0.2 2.8e-16 59.1 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS20424.1 - 7.1e-12 45.3 0.1 0.00013 22.0 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif Nup35_RRM_2 PF14605.6 KOS20424.1 - 3.6e-06 26.9 0.0 0.014 15.3 0.0 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif TFIIA PF03153.13 KOS20424.1 - 0.015 15.3 22.9 0.022 14.8 22.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRM_3 PF08777.11 KOS20424.1 - 0.065 13.3 0.1 6.8 6.8 0.0 2.8 2 0 0 2 2 2 0 RNA binding motif Flavoprotein PF02441.19 KOS20424.1 - 2.8 7.7 4.4 4.3 7.1 4.4 1.3 1 0 0 1 1 1 0 Flavoprotein Thioredoxin_14 PF18402.1 KOS20424.1 - 3 7.7 5.0 4.9 7.0 5.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Ribosomal_L5e PF17144.4 KOS20425.1 - 6.5e-81 270.1 0.1 1.2e-80 269.3 0.1 1.4 1 0 0 1 1 1 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 KOS20425.1 - 1.8e-33 115.3 7.9 1.8e-33 115.3 7.9 2.0 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 KOS20425.1 - 0.0055 17.1 0.1 0.013 15.8 0.1 1.6 1 0 0 1 1 1 1 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast CTP_transf_like PF01467.26 KOS20426.1 - 1e-32 113.3 0.0 2.8e-32 111.9 0.0 1.8 2 0 0 2 2 2 1 Cytidylyltransferase-like BSP_II PF05432.11 KOS20426.1 - 0.084 12.6 8.1 0.16 11.6 8.1 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) adh_short PF00106.25 KOS20427.1 - 4.7e-17 62.1 0.0 9e-16 57.9 0.0 2.5 2 1 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20427.1 - 4.4e-08 33.0 0.0 1e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20427.1 - 3.1e-07 30.5 0.0 6.8e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS20427.1 - 4.6e-06 26.3 0.0 1e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS20427.1 - 7.9e-05 22.2 1.4 0.00021 20.8 0.0 2.2 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase Ldh_1_N PF00056.23 KOS20427.1 - 0.068 13.3 0.0 12 6.0 0.0 2.6 2 1 0 2 2 2 0 lactate/malate dehydrogenase, NAD binding domain Glyco_trans_4_4 PF13579.6 KOS20427.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.6 2 0 0 2 2 2 0 Glycosyl transferase 4-like domain MFS_MOT1 PF16983.5 KOS20428.1 - 3.3e-60 201.3 28.3 1.4e-33 115.6 9.7 2.5 2 0 0 2 2 2 2 Molybdate transporter of MFS superfamily HSP20 PF00011.21 KOS20430.1 - 1e-17 64.2 0.3 5.2e-12 45.8 0.3 2.7 2 1 0 2 2 2 2 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOS20430.1 - 8.5e-06 25.2 0.0 0.029 13.9 0.0 2.3 2 0 0 2 2 2 2 HSP20-like domain found in ArsA DUF853 PF05872.12 KOS20430.1 - 0.22 10.1 0.7 0.26 9.8 0.7 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Proteasome PF00227.26 KOS20431.1 - 2.1e-29 102.4 0.2 3.8e-29 101.5 0.2 1.4 1 1 0 1 1 1 1 Proteasome subunit Pkinase PF00069.25 KOS20432.1 - 7.4e-29 100.9 0.0 1e-28 100.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20432.1 - 1.7e-07 30.8 0.0 2.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4667 PF15700.5 KOS20432.1 - 0.0018 18.4 4.3 0.0027 17.8 4.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) Secretin_N_2 PF07655.13 KOS20432.1 - 0.11 13.0 14.6 0.95 10.0 4.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain SPX PF03105.19 KOS20432.1 - 0.15 11.9 2.1 0.19 11.6 2.1 1.2 1 0 0 1 1 1 0 SPX domain DUF508 PF04370.12 KOS20432.1 - 0.3 10.8 4.2 0.52 10.0 4.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF508) NAD_binding_6 PF08030.12 KOS20434.1 - 8.2e-19 68.3 0.0 1.1e-18 67.8 0.0 1.2 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 KOS20434.1 - 6.9e-18 65.0 9.6 1.2e-17 64.2 9.6 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KOS20434.1 - 3.1e-07 30.5 0.0 8.5e-07 29.0 0.0 1.7 2 0 0 2 2 2 1 FAD-binding domain NAD_binding_1 PF00175.21 KOS20434.1 - 0.052 14.2 0.0 3.3 8.4 0.0 2.4 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Rad51 PF08423.11 KOS20435.1 - 9.5e-128 424.8 0.0 1.2e-127 424.5 0.0 1.1 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.6 KOS20435.1 - 3.3e-09 36.6 0.0 4.8e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 KOS20435.1 - 5.6e-08 32.6 0.0 7.7e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein HHH_5 PF14520.6 KOS20435.1 - 3.5e-06 27.5 1.8 7.3e-06 26.5 0.5 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain ATPase PF06745.13 KOS20435.1 - 9.2e-06 25.2 0.0 2.1e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 KOS20435.1 - 0.011 15.0 0.1 0.049 13.0 0.0 1.8 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain AAA_24 PF13479.6 KOS20435.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ssDNA_TraI_N PF18272.1 KOS20435.1 - 0.096 12.7 0.2 0.59 10.2 0.1 2.1 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain PAXNEB PF05625.11 KOS20435.1 - 0.14 11.2 0.5 0.64 9.1 0.1 1.9 2 0 0 2 2 2 0 PAXNEB protein Per1 PF04080.13 KOS20436.1 - 2.1e-107 358.7 6.7 2.5e-107 358.4 6.7 1.1 1 0 0 1 1 1 1 Per1-like family Aldedh PF00171.22 KOS20437.1 - 7.7e-106 354.4 0.0 9.5e-106 354.1 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ribosomal_L21p PF00829.21 KOS20438.1 - 1.5e-14 54.1 0.0 1.8e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 KOS20439.1 - 5.5e-48 163.6 0.0 8e-48 163.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20439.1 - 1.8e-19 70.1 0.0 2.6e-19 69.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 KOS20439.1 - 9.6e-05 22.4 0.5 1.5 8.7 0.0 3.6 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kinase-like PF14531.6 KOS20439.1 - 0.011 15.0 0.0 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 KOS20439.1 - 0.033 13.8 0.2 0.13 11.8 0.1 2.1 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 KOS20439.1 - 0.11 12.2 0.0 5.3 6.6 0.0 2.4 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Ribosomal_S8e PF01201.22 KOS20440.1 - 5.8e-45 152.8 1.5 1e-44 152.1 1.5 1.4 1 1 0 1 1 1 1 Ribosomal protein S8e ERCC4 PF02732.15 KOS20441.1 - 1.3e-24 87.2 0.0 2.2e-24 86.5 0.0 1.4 1 0 0 1 1 1 1 ERCC4 domain PGM_PMM_I PF02878.16 KOS20442.1 - 3.8e-18 65.5 0.7 4.3e-09 36.2 0.0 3.1 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 KOS20442.1 - 1.7e-09 37.7 0.7 5.7e-09 36.0 0.2 2.3 2 1 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 KOS20442.1 - 0.0021 18.7 0.6 0.088 13.4 0.6 3.0 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 KOS20442.1 - 0.022 15.0 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PhoD PF09423.10 KOS20443.1 - 0.00064 18.8 0.0 0.018 14.1 0.0 2.1 2 0 0 2 2 2 2 PhoD-like phosphatase TMEM101 PF15111.6 KOS20444.1 - 0.056 13.0 0.0 0.068 12.7 0.0 1.1 1 0 0 1 1 1 0 TMEM101 protein family TMEM52 PF14979.6 KOS20444.1 - 2.7 7.9 4.4 0.93 9.4 1.4 1.7 1 1 1 2 2 2 0 Transmembrane 52 Rhodanese PF00581.20 KOS20445.1 - 2.5e-13 50.5 0.0 2.9e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain SPX PF03105.19 KOS20446.1 - 0.079 12.9 5.2 0.12 12.3 5.2 1.2 1 0 0 1 1 1 0 SPX domain HD_3 PF13023.6 KOS20447.1 - 3.6e-36 124.6 0.0 4.5e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 KOS20447.1 - 1.4e-05 24.9 0.0 2.1e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 KOS20447.1 - 0.02 15.1 0.0 0.068 13.4 0.0 1.9 1 1 0 1 1 1 0 HD domain Erg28 PF03694.13 KOS20448.1 - 3.8e-42 143.1 0.1 4.6e-42 142.9 0.1 1.1 1 0 0 1 1 1 1 Erg28 like protein adh_short PF00106.25 KOS20449.1 - 1.4e-33 116.0 0.0 1.8e-33 115.7 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20449.1 - 2.1e-20 73.3 0.0 2.8e-20 72.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20449.1 - 0.0002 21.3 0.1 0.00044 20.2 0.1 1.6 1 1 0 1 1 1 1 KR domain Glyco_hydro_67M PF07488.12 KOS20449.1 - 0.0092 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 middle domain Polysacc_synt_2 PF02719.15 KOS20449.1 - 0.013 14.7 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 KOS20449.1 - 0.016 15.4 0.1 0.092 13.0 0.0 2.0 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain ZZ PF00569.17 KOS20450.1 - 3.8e-09 36.2 4.1 6.9e-09 35.4 4.1 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type Myb_DNA-binding PF00249.31 KOS20450.1 - 5.1e-09 36.2 0.0 2.9e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 Myb-like DNA-binding domain SWIRM PF04433.17 KOS20450.1 - 6.1e-08 32.9 0.0 2e-07 31.2 0.0 1.8 1 0 0 1 1 1 1 SWIRM domain GalP_UDP_transf PF01087.22 KOS20451.1 - 2.9e-68 229.9 0.0 6.1e-67 225.6 0.0 2.1 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain GalP_UDP_tr_C PF02744.17 KOS20451.1 - 4.1e-54 182.8 0.0 9.1e-54 181.7 0.0 1.5 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain HIT PF01230.23 KOS20451.1 - 0.002 18.8 0.0 0.0051 17.5 0.0 1.7 1 0 0 1 1 1 1 HIT domain Nucleoporin_N PF08801.11 KOS20452.1 - 2.2e-94 316.7 0.2 3.7e-94 315.9 0.1 1.5 2 0 0 2 2 2 1 Nup133 N terminal like Nucleoporin_C PF03177.14 KOS20452.1 - 2.6e-49 168.5 0.4 1.8e-48 165.7 0.1 2.2 2 1 1 3 3 3 1 Non-repetitive/WGA-negative nucleoporin C-terminal Sugar_tr PF00083.24 KOS20454.1 - 1.3e-24 86.9 7.5 3e-23 82.4 5.4 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOS20454.1 - 2.9e-14 52.8 11.4 4.7e-14 52.1 11.0 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4131 PF13567.6 KOS20454.1 - 0.0042 16.8 0.4 0.66 9.6 0.1 3.3 2 1 1 3 3 3 1 Domain of unknown function (DUF4131) Abhydrolase_1 PF00561.20 KOS20455.1 - 8.7e-45 153.4 0.0 2.1e-44 152.1 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS20455.1 - 0.0023 18.6 5.2 0.0056 17.3 5.2 1.8 1 1 0 1 1 1 1 Alpha/beta hydrolase family AflR PF08493.10 KOS20455.1 - 0.0025 17.3 1.2 0.004 16.7 1.2 1.4 1 0 0 1 1 1 1 Aflatoxin regulatory protein Mucin PF01456.17 KOS20455.1 - 0.14 12.2 15.4 0.26 11.3 15.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 KOS20455.1 - 0.37 10.8 10.7 0.77 9.7 10.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 KOS20455.1 - 4.2 5.4 16.3 5.7 5.0 16.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RSN1_7TM PF02714.15 KOS20456.1 - 2e-80 270.0 22.5 2e-80 270.0 22.5 2.7 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOS20456.1 - 9.9e-39 132.6 5.8 2.3e-38 131.4 3.6 2.6 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOS20456.1 - 1.9e-36 125.9 0.0 3e-36 125.3 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 KOS20456.1 - 5.2e-26 90.6 0.0 2.3e-25 88.6 0.0 2.0 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter kleA_kleC PF17383.2 KOS20456.1 - 0.015 15.6 0.1 0.038 14.3 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A RRM_1 PF00076.22 KOS20456.1 - 0.16 11.8 0.2 0.83 9.5 0.1 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SKG6 PF08693.10 KOS20457.1 - 2.1e-05 23.8 0.0 6e-05 22.4 0.0 1.8 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DUF4381 PF14316.6 KOS20457.1 - 0.024 14.9 0.3 0.054 13.7 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) SOGA PF11365.8 KOS20458.1 - 0.01 16.9 0.4 0.019 16.1 0.2 1.6 2 0 0 2 2 2 0 Protein SOGA YscO-like PF16789.5 KOS20458.1 - 0.03 14.4 0.5 0.044 13.8 0.5 1.3 1 0 0 1 1 1 0 YscO-like protein Methyltransf_25 PF13649.6 KOS20459.1 - 1.2e-11 45.1 0.0 3e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 KOS20459.1 - 8e-11 41.9 0.0 1.3e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 KOS20459.1 - 3.3e-10 39.9 0.0 6.5e-10 39.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS20459.1 - 2.1e-08 34.7 0.0 5.8e-08 33.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 KOS20459.1 - 4.5e-07 29.1 0.1 6.6e-07 28.6 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_23 PF13489.6 KOS20459.1 - 1.1e-06 28.6 0.0 1.8e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 KOS20459.1 - 4.6e-05 23.4 0.0 8e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOS20459.1 - 5.1e-05 22.9 0.1 9.3e-05 22.0 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 KOS20459.1 - 0.00023 21.9 0.0 0.00042 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOS20459.1 - 0.0005 19.5 0.0 0.00068 19.0 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 KOS20459.1 - 0.0012 18.9 0.0 0.0027 17.9 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase PRMT5 PF05185.16 KOS20459.1 - 0.0032 17.3 0.1 0.0063 16.4 0.1 1.5 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_32 PF13679.6 KOS20459.1 - 0.0075 16.3 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 KOS20459.1 - 0.0091 15.8 0.1 0.016 15.0 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein PCMT PF01135.19 KOS20459.1 - 0.0097 15.7 0.2 0.015 15.0 0.2 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 KOS20459.1 - 0.0098 15.3 0.3 0.07 12.5 0.0 2.3 2 0 0 2 2 2 1 Tellurite resistance protein TehB PRMT5_C PF17286.2 KOS20459.1 - 0.015 15.2 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Methyltransf_16 PF10294.9 KOS20459.1 - 0.039 13.7 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Lysine methyltransferase RrnaAD PF00398.20 KOS20459.1 - 0.05 12.7 0.0 0.099 11.7 0.0 1.5 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Cons_hypoth95 PF03602.15 KOS20459.1 - 0.068 12.8 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_15 PF09445.10 KOS20459.1 - 0.073 12.6 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase DOT1 PF08123.13 KOS20459.1 - 0.083 12.4 0.4 0.21 11.1 0.2 1.7 1 1 0 1 1 1 0 Histone methylation protein DOT1 DUF1765 PF08578.10 KOS20460.1 - 6.3e-44 149.4 2.3 1.3e-43 148.4 2.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Tam41_Mmp37 PF09139.11 KOS20461.1 - 4.8e-115 384.4 0.0 6.2e-115 384.1 0.0 1.0 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial MAD PF05557.13 KOS20462.1 - 1.6e-58 198.7 54.0 2.7e-58 197.9 53.5 1.5 1 1 0 1 1 1 1 Mitotic checkpoint protein Peptidase_M61 PF05299.12 KOS20462.1 - 0.036 14.5 0.3 0.036 14.5 0.3 3.4 3 1 1 4 4 4 0 M61 glycyl aminopeptidase muHD PF10291.9 KOS20463.1 - 2.1e-57 194.6 0.0 2.1e-56 191.3 0.0 2.2 2 0 0 2 2 2 1 Muniscin C-terminal mu homology domain FCH PF00611.23 KOS20463.1 - 1.8e-06 28.1 0.0 6.4e-06 26.4 0.0 1.9 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain BAR PF03114.18 KOS20463.1 - 1.9e-05 24.4 4.5 3.1e-05 23.7 4.5 1.2 1 0 0 1 1 1 1 BAR domain Vps5 PF09325.10 KOS20463.1 - 0.022 14.3 6.1 0.046 13.3 6.1 1.4 1 0 0 1 1 1 0 Vps5 C terminal like PAS_10 PF13596.6 KOS20463.1 - 0.069 13.8 0.3 0.18 12.4 0.3 1.7 1 0 0 1 1 1 0 PAS domain 4HFCP_synth PF04476.13 KOS20463.1 - 0.15 11.8 0.5 0.27 10.9 0.5 1.4 1 0 0 1 1 1 0 4-HFC-P synthase Exonuc_VII_L PF02601.15 KOS20463.1 - 0.23 11.0 5.7 0.39 10.2 5.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 KOS20463.1 - 2.8 7.0 9.0 4.7 6.2 9.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 U3_snoRNA_assoc PF08297.11 KOS20465.1 - 0.22 12.3 8.1 0.77 10.5 8.1 2.1 1 0 0 1 1 1 0 U3 snoRNA associated FAM27 PF15832.5 KOS20465.1 - 0.25 11.9 9.9 0.87 10.2 9.9 1.9 1 0 0 1 1 1 0 FAM27 D and E protein family Dicty_REP PF05086.12 KOS20465.1 - 1 7.3 7.7 1.5 6.7 7.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RR_TM4-6 PF06459.12 KOS20465.1 - 5.4 6.8 9.4 12 5.6 9.4 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L1 PF00687.21 KOS20469.1 - 1.4e-61 207.9 0.0 2e-61 207.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Palm_thioest PF02089.15 KOS20470.1 - 1.8e-76 257.2 0.0 2.2e-76 256.9 0.0 1.1 1 0 0 1 1 1 1 Palmitoyl protein thioesterase HAD_2 PF13419.6 KOS20471.1 - 0.00022 21.4 0.0 0.00033 20.8 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS20471.1 - 0.0065 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOS20471.1 - 0.041 14.1 0.0 0.063 13.6 0.0 1.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase MSA-2c PF12238.8 KOS20471.1 - 0.6 10.1 1.6 0.94 9.4 1.6 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c zf-MIZ PF02891.20 KOS20472.1 - 3.4e-10 39.5 0.9 7.4e-10 38.4 0.9 1.6 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-Nse PF11789.8 KOS20472.1 - 0.01 15.6 0.5 0.027 14.3 0.5 1.7 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Ribosomal_S21 PF01165.20 KOS20473.1 - 8.3e-08 31.8 11.2 1.3e-07 31.2 11.2 1.2 1 0 0 1 1 1 1 Ribosomal protein S21 PWI PF01480.17 KOS20474.1 - 7.7e-13 48.6 0.1 1.6e-12 47.5 0.1 1.6 1 0 0 1 1 1 1 PWI domain MSA-2c PF12238.8 KOS20474.1 - 0.035 14.1 0.5 0.035 14.1 0.5 2.2 3 0 0 3 3 3 0 Merozoite surface antigen 2c Polysacc_deac_1 PF01522.21 KOS20475.1 - 2.3e-28 98.6 0.0 3.8e-28 97.9 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Chitin_bind_1 PF00187.19 KOS20475.1 - 1e-15 57.9 38.5 1.7e-08 34.8 14.4 2.4 2 0 0 2 2 2 2 Chitin recognition protein Coatomer_WDAD PF04053.14 KOS20476.1 - 1.3e-168 561.7 0.0 2.5e-168 560.8 0.0 1.5 1 0 0 1 1 1 1 Coatomer WD associated region WD40 PF00400.32 KOS20476.1 - 3.2e-38 129.0 8.5 1.1e-05 26.1 0.0 8.8 9 0 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20476.1 - 2.2e-08 34.3 0.1 4 7.8 0.0 5.9 4 2 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20476.1 - 0.00012 20.8 3.5 0.093 11.4 0.1 3.7 1 1 1 3 3 3 2 Nucleoporin Nup120/160 MetallophosC PF16370.5 KOS20476.1 - 0.058 13.6 0.0 0.26 11.5 0.0 1.9 1 1 1 2 2 2 0 C terminal of Calcineurin-like phosphoesterase BBS2_Mid PF14783.6 KOS20476.1 - 0.077 13.0 0.0 17 5.5 0.0 3.4 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Sugar_tr PF00083.24 KOS20477.1 - 4.4e-33 114.8 32.1 7.7e-21 74.5 11.0 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOS20477.1 - 1e-19 70.7 40.1 4e-10 39.1 24.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MASE2 PF05230.11 KOS20477.1 - 0.036 14.1 0.3 0.29 11.2 0.0 2.7 2 0 0 2 2 2 0 MASE2 domain Glyco_hydro_3_C PF01915.22 KOS20478.1 - 2.3e-50 171.4 0.0 4.1e-50 170.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS20478.1 - 2.3e-42 145.5 0.0 3.9e-42 144.7 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS20478.1 - 1e-21 76.8 0.0 2e-21 75.9 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Mannitol_dh_C PF08125.13 KOS20479.1 - 9.6e-41 139.9 0.1 1.5e-40 139.2 0.1 1.2 1 0 0 1 1 1 1 Mannitol dehydrogenase C-terminal domain Mannitol_dh PF01232.23 KOS20479.1 - 7.2e-18 65.2 0.3 2.3e-17 63.6 0.0 1.9 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain UDPG_MGDP_dh_N PF03721.14 KOS20479.1 - 0.00065 19.3 1.5 0.001 18.7 0.4 1.9 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF3842 PF12953.7 KOS20479.1 - 0.049 14.0 0.5 0.099 13.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3842) HAUS6_N PF14661.6 KOS20480.1 - 2.7e-46 158.0 0.7 4.4e-46 157.3 0.7 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus Pkinase PF00069.25 KOS20481.1 - 1.8e-69 234.0 0.0 2.5e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20481.1 - 4.4e-32 111.4 0.0 6.3e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 KOS20481.1 - 5.7e-12 46.1 2.0 1.7e-11 44.6 2.0 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 KOS20481.1 - 5e-06 25.7 0.1 8.2e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 KOS20481.1 - 0.0033 16.8 0.0 0.0063 15.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like C2 PF00168.30 KOS20481.1 - 0.0056 16.9 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain APH PF01636.23 KOS20481.1 - 0.12 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PGI PF00342.19 KOS20482.1 - 6.8e-226 750.5 0.1 7.8e-226 750.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase MelC1 PF06236.11 KOS20482.1 - 0.052 13.6 0.2 0.13 12.4 0.2 1.6 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 DUF1681 PF07933.14 KOS20483.1 - 2.5e-51 173.3 0.0 3.2e-51 172.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) GCR1_C PF12550.8 KOS20483.1 - 0.17 12.2 0.0 0.27 11.6 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes SR-25 PF10500.9 KOS20483.1 - 2 8.0 11.0 3.4 7.2 11.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein H_lectin PF09458.10 KOS20484.1 - 3.1e-20 72.1 0.5 5.7e-20 71.3 0.5 1.5 1 0 0 1 1 1 1 H-type lectin domain NPV_P10 PF05531.12 KOS20484.1 - 6.1e-06 26.6 17.7 0.017 15.6 5.1 4.7 1 1 3 4 4 4 2 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 KOS20484.1 - 2.1e-05 24.4 18.4 0.027 14.5 2.1 4.1 1 1 3 4 4 4 2 FlxA-like protein CENP-F_leu_zip PF10473.9 KOS20484.1 - 4.4e-05 23.5 4.3 6.9e-05 22.9 1.6 2.3 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 KOS20484.1 - 8.8e-05 22.7 4.5 0.003 17.8 1.9 2.5 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 KOS20484.1 - 0.0014 18.6 0.8 0.0014 18.6 0.8 2.8 1 1 2 3 3 3 2 Laminin Domain II DUF1664 PF07889.12 KOS20484.1 - 0.0015 18.6 5.6 0.089 12.8 0.0 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Tropomyosin_1 PF12718.7 KOS20484.1 - 0.0031 17.7 4.5 0.044 13.9 0.0 2.7 1 1 2 3 3 3 1 Tropomyosin like HMMR_N PF15905.5 KOS20484.1 - 0.0036 16.8 3.4 0.0057 16.2 3.4 1.3 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal FlaC_arch PF05377.11 KOS20484.1 - 0.0039 17.5 1.2 1.9 8.9 0.0 3.6 3 1 1 4 4 3 1 Flagella accessory protein C (FlaC) DUF4795 PF16043.5 KOS20484.1 - 0.004 16.8 3.3 0.011 15.4 3.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4795) KASH_CCD PF14662.6 KOS20484.1 - 0.0041 17.0 5.3 0.0088 15.9 5.3 1.5 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF2730 PF10805.8 KOS20484.1 - 0.0045 17.1 5.5 0.073 13.2 0.2 3.2 1 1 2 3 3 3 2 Protein of unknown function (DUF2730) Spc7 PF08317.11 KOS20484.1 - 0.0075 15.2 7.5 0.012 14.5 0.4 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein AAA_13 PF13166.6 KOS20484.1 - 0.0087 14.8 5.6 0.011 14.4 5.6 1.1 1 0 0 1 1 1 1 AAA domain IFT57 PF10498.9 KOS20484.1 - 0.0093 15.0 0.4 0.012 14.6 0.4 1.2 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Myosin_tail_1 PF01576.19 KOS20484.1 - 0.015 13.2 6.0 0.032 12.1 5.6 1.6 1 1 0 1 1 1 0 Myosin tail DUF4407 PF14362.6 KOS20484.1 - 0.019 14.3 9.7 0.02 14.3 7.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Tropomyosin PF00261.20 KOS20484.1 - 0.027 13.8 1.5 0.043 13.2 1.1 1.5 1 1 0 1 1 1 0 Tropomyosin DUF2408 PF10303.9 KOS20484.1 - 0.03 14.9 0.4 15 6.2 1.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) BLOC1_2 PF10046.9 KOS20484.1 - 0.042 14.1 0.9 0.042 14.1 0.9 4.0 2 1 3 5 5 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CLZ PF16526.5 KOS20484.1 - 0.043 14.2 9.6 5.6 7.4 0.3 3.9 1 1 3 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ADIP PF11559.8 KOS20484.1 - 0.045 13.8 9.0 2 8.5 1.4 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF16 PF01519.16 KOS20484.1 - 0.045 14.2 7.5 1.3e+02 3.1 7.5 2.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Fez1 PF06818.15 KOS20484.1 - 0.046 14.2 3.3 0.14 12.6 2.1 2.1 1 1 1 2 2 2 0 Fez1 Cast PF10174.9 KOS20484.1 - 0.061 11.5 4.0 0.11 10.7 3.8 1.4 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone Taxilin PF09728.9 KOS20484.1 - 0.068 12.3 2.5 0.097 11.8 2.2 1.3 1 1 0 1 1 1 0 Myosin-like coiled-coil protein SlyX PF04102.12 KOS20484.1 - 0.075 13.7 22.6 0.067 13.8 1.4 5.1 1 1 3 5 5 5 0 SlyX Dynamitin PF04912.14 KOS20484.1 - 0.08 12.3 15.0 0.096 12.0 13.1 1.9 1 1 0 1 1 1 0 Dynamitin HrpB7 PF09486.10 KOS20484.1 - 0.096 13.1 13.6 1.2 9.6 12.0 2.5 1 1 1 2 2 1 0 Bacterial type III secretion protein (HrpB7) DUF724 PF05266.14 KOS20484.1 - 0.11 12.3 1.3 1.7 8.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HAP1_N PF04849.13 KOS20484.1 - 0.12 11.6 9.6 1.2 8.3 0.4 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DUF1319 PF07028.11 KOS20484.1 - 0.14 12.4 2.7 0.72 10.1 0.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) TolA_bind_tri PF16331.5 KOS20484.1 - 0.15 12.1 18.6 2.6 8.2 2.2 4.2 2 1 2 4 4 4 0 TolA binding protein trimerisation FAM76 PF16046.5 KOS20484.1 - 0.16 11.3 3.4 2.3 7.5 3.4 2.0 1 1 0 1 1 1 0 FAM76 protein ATG16 PF08614.11 KOS20484.1 - 0.17 12.1 13.8 0.092 13.0 9.8 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF5082 PF16888.5 KOS20484.1 - 0.17 12.1 10.9 1.1 9.6 0.0 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Fmp27_WPPW PF10359.9 KOS20484.1 - 0.2 10.5 2.3 1.1 8.0 0.1 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF4349 PF14257.6 KOS20484.1 - 0.23 10.9 9.6 0.57 9.6 1.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Filament PF00038.21 KOS20484.1 - 0.37 10.3 7.2 0.72 9.4 0.1 2.4 1 1 2 3 3 3 0 Intermediate filament protein YabA PF06156.13 KOS20484.1 - 0.43 11.2 3.4 3.5 8.3 0.1 3.3 1 1 1 2 2 2 0 Initiation control protein YabA DUF2968 PF11180.8 KOS20484.1 - 0.44 10.2 23.0 0.24 11.0 4.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) ABC_tran_CTD PF16326.5 KOS20484.1 - 0.53 10.6 15.9 12 6.2 2.4 4.0 1 1 2 3 3 3 0 ABC transporter C-terminal domain Prefoldin_2 PF01920.20 KOS20484.1 - 0.6 10.1 7.6 1.5 8.8 0.2 3.1 1 1 1 2 2 2 0 Prefoldin subunit DUF4140 PF13600.6 KOS20484.1 - 0.7 10.4 12.4 13 6.3 1.3 3.8 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) APG6_N PF17675.1 KOS20484.1 - 0.76 10.3 10.2 26 5.3 10.2 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region FliD_N PF02465.18 KOS20484.1 - 0.81 10.4 5.9 18 6.1 1.0 3.9 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Swi5 PF07061.11 KOS20484.1 - 0.98 9.5 7.5 4.8 7.3 0.1 3.9 1 1 1 3 3 3 0 Swi5 DUF3450 PF11932.8 KOS20484.1 - 1.3 8.3 13.5 0.064 12.6 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 KOS20484.1 - 1.4 9.0 14.8 3.4 7.8 1.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein SKA1 PF07160.12 KOS20484.1 - 1.4 8.7 8.0 0.43 10.4 0.3 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF4618 PF15397.6 KOS20484.1 - 1.9 7.8 8.8 7.8 5.8 0.3 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) Lectin_N PF03954.14 KOS20484.1 - 2.1 8.1 7.2 98 2.7 7.0 2.8 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Nsp1_C PF05064.13 KOS20484.1 - 4 7.3 6.0 1.6 8.6 1.1 2.5 1 1 0 2 2 2 0 Nsp1-like C-terminal region Uso1_p115_C PF04871.13 KOS20484.1 - 4.4 7.7 9.6 7.3 7.0 2.0 2.5 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cob_adeno_trans PF01923.18 KOS20484.1 - 4.9 7.3 8.1 1e+02 3.0 8.1 2.4 1 1 0 1 1 1 0 Cobalamin adenosyltransferase ZapB PF06005.12 KOS20484.1 - 6.2 7.3 9.3 5.8 7.4 2.3 3.2 1 1 1 2 2 2 0 Cell division protein ZapB Fib_alpha PF08702.10 KOS20484.1 - 7.7 6.7 6.3 13 5.9 0.9 2.7 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family LPP PF04728.13 KOS20484.1 - 8 6.9 21.5 3.7 8.0 3.7 5.4 3 2 2 5 5 5 0 Lipoprotein leucine-zipper FmiP_Thoc5 PF09766.9 KOS20484.1 - 9 5.5 9.5 0.13 11.6 1.6 1.8 2 1 0 2 2 1 0 Fms-interacting protein/Thoc5 DivIC PF04977.15 KOS20484.1 - 9.4 6.1 13.3 60 3.5 6.0 4.2 1 1 3 4 4 4 0 Septum formation initiator Ribosomal_L31e PF01198.19 KOS20485.1 - 2.5e-06 27.6 0.3 11 6.3 0.0 4.8 1 1 4 5 5 5 0 Ribosomal protein L31e NPV_P10 PF05531.12 KOS20485.1 - 4.2e-05 23.9 17.3 0.11 13.0 2.6 4.0 1 1 4 5 5 5 5 Nucleopolyhedrovirus P10 protein FliH PF02108.16 KOS20485.1 - 8.9e-05 22.6 4.4 0.48 10.5 0.2 3.5 1 1 1 2 2 2 2 Flagellar assembly protein FliH Trimer_CC PF08954.11 KOS20485.1 - 0.00012 21.5 29.6 0.66 9.6 0.4 5.5 2 2 3 5 5 5 4 Trimerisation motif ABC_tran_CTD PF16326.5 KOS20485.1 - 0.00013 22.2 21.1 0.06 13.6 3.1 3.9 1 1 4 5 5 5 5 ABC transporter C-terminal domain IFS PF16718.5 KOS20485.1 - 0.00015 21.9 5.7 5.8 7.0 0.1 4.6 1 1 4 5 5 5 0 Immunity factor for SPN DUF5344 PF17279.2 KOS20485.1 - 0.00017 22.1 14.3 0.17 12.5 1.6 3.9 2 1 1 4 4 4 2 Family of unknown function (DUF5344) PspB PF06667.12 KOS20485.1 - 0.00024 21.1 20.4 2.2 8.4 0.5 5.5 2 1 3 6 6 5 3 Phage shock protein B Phage_holin_6_1 PF09682.10 KOS20485.1 - 0.002 18.5 8.8 0.24 11.8 1.5 2.4 1 1 1 2 2 2 2 Bacteriophage holin of superfamily 6 (Holin_LLH) NOD PF06816.13 KOS20485.1 - 0.0031 17.1 1.8 27 4.5 0.0 4.1 1 1 3 4 4 4 0 NOTCH protein DUF2681 PF10883.8 KOS20485.1 - 0.0056 17.1 14.7 0.8 10.2 0.1 3.9 1 1 3 4 4 4 1 Protein of unknown function (DUF2681) CLZ PF16526.5 KOS20485.1 - 0.0057 17.0 25.0 0.42 11.0 3.8 5.7 1 1 4 5 5 5 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels HALZ PF02183.18 KOS20485.1 - 0.0082 16.3 0.2 0.0082 16.3 0.2 3.4 5 0 0 5 5 1 1 Homeobox associated leucine zipper LepB_N PF18640.1 KOS20485.1 - 0.0097 15.5 4.4 1.2 8.7 0.2 2.9 1 1 2 3 3 3 1 LepB N-terminal domain BAGE PF08180.11 KOS20485.1 - 0.011 15.8 1.6 1.1e+02 3.0 0.0 4.4 4 0 0 4 4 4 0 B melanoma antigen family PG_binding_1 PF01471.18 KOS20485.1 - 0.02 15.1 11.0 18 5.6 0.4 4.5 1 1 2 3 3 3 0 Putative peptidoglycan binding domain EF-G-binding_N PF07299.11 KOS20485.1 - 0.025 15.1 17.0 0.067 13.7 1.9 3.4 2 2 1 3 3 3 0 Elongation factor G-binding protein, N-terminal AcetDehyd-dimer PF09290.11 KOS20485.1 - 0.028 14.6 5.4 14 5.8 0.1 3.7 1 1 2 3 3 3 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation GAT PF03127.14 KOS20485.1 - 0.03 14.6 14.2 4.1 7.8 1.7 3.9 1 1 2 3 3 3 0 GAT domain DLP_helical PF18709.1 KOS20485.1 - 0.032 13.5 14.2 0.2 10.8 1.7 2.4 1 1 1 2 2 2 0 Dynamin-like helical domain CdvA PF18822.1 KOS20485.1 - 0.041 13.7 19.7 5.8 6.8 0.3 5.2 1 1 5 6 6 6 0 CdvA-like coiled-coil domain YojJ PF10372.9 KOS20485.1 - 0.05 13.7 9.9 10 6.3 0.1 4.3 1 1 3 4 4 4 0 Bacterial membrane-spanning protein N-terminus OmpH PF03938.14 KOS20485.1 - 0.051 13.9 27.1 0.55 10.6 7.3 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) MAAL_C PF07476.11 KOS20485.1 - 0.052 12.7 2.6 0.96 8.6 0.3 2.2 1 1 2 3 3 3 0 Methylaspartate ammonia-lyase C-terminus DIL PF01843.19 KOS20485.1 - 0.058 13.7 7.1 2.2 8.6 1.1 3.0 1 1 2 3 3 3 0 DIL domain Desmo_N PF06771.11 KOS20485.1 - 0.059 13.7 0.5 12 6.4 0.1 2.4 1 1 2 3 3 3 0 Viral Desmoplakin N-terminus DUF3417 PF11897.8 KOS20485.1 - 0.07 13.6 8.9 2.3 8.7 1.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3417) Sipho_Gp157 PF05565.11 KOS20485.1 - 0.13 12.3 12.7 3 7.8 5.3 3.6 1 1 3 4 4 4 0 Siphovirus Gp157 Toxin_trans PF07952.12 KOS20485.1 - 0.14 11.3 3.0 0.33 10.0 2.1 1.9 1 1 1 2 2 2 0 Clostridium neurotoxin, Translocation domain DUF4549 PF15082.6 KOS20485.1 - 0.16 11.7 11.2 4.9 6.9 0.5 3.7 1 1 4 5 5 5 0 Domain of unknown function (DUF4549) DUF3086 PF11285.8 KOS20485.1 - 0.17 11.0 15.2 0.19 10.8 11.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) Syntaxin_2 PF14523.6 KOS20485.1 - 0.38 11.2 20.8 11 6.5 11.1 2.7 1 1 1 2 2 2 0 Syntaxin-like protein DUF2205 PF10224.9 KOS20485.1 - 0.47 10.5 21.4 2.1 8.4 0.8 5.1 1 1 4 5 5 5 0 Short coiled-coil protein DUF1839 PF08893.10 KOS20485.1 - 0.47 9.6 7.7 3.5 6.7 1.2 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF1839) DUF1664 PF07889.12 KOS20485.1 - 0.51 10.4 13.9 0.25 11.4 2.9 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) EcoEI_R_C PF08463.10 KOS20485.1 - 0.59 10.2 17.5 1.8 8.6 1.1 3.1 2 1 3 5 5 4 0 EcoEI R protein C-terminal Prominin PF05478.11 KOS20485.1 - 0.71 7.8 15.7 0.46 8.4 3.5 2.0 1 1 1 2 2 2 0 Prominin HlyD_2 PF12700.7 KOS20485.1 - 0.8 8.4 8.2 1 8.0 8.2 1.2 1 0 0 1 1 1 0 HlyD family secretion protein GlnE PF03710.15 KOS20485.1 - 0.83 9.0 11.5 0.64 9.4 3.1 2.0 1 1 1 2 2 2 0 Glutamate-ammonia ligase adenylyltransferase DUF5082 PF16888.5 KOS20485.1 - 0.83 9.9 13.5 16 5.8 13.4 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) HsdM_N PF12161.8 KOS20485.1 - 0.83 10.3 8.6 6 7.5 1.7 2.7 1 1 1 2 2 2 0 HsdM N-terminal domain FUSC PF04632.12 KOS20485.1 - 0.98 7.9 11.7 1.9 7.0 11.6 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family KGK PF08872.10 KOS20485.1 - 1 9.9 6.4 4.1 7.9 0.6 2.9 1 1 2 3 3 3 0 KGK domain Trigger_N PF05697.13 KOS20485.1 - 1.1 9.5 13.1 16 5.8 0.2 4.5 1 1 4 5 5 5 0 Bacterial trigger factor protein (TF) H-kinase_dim PF02895.14 KOS20485.1 - 1.2 9.5 23.5 1.5 9.3 2.7 4.5 1 1 1 2 2 1 0 Signal transducing histidine kinase, homodimeric domain DUF4199 PF13858.6 KOS20485.1 - 1.3 9.4 3.9 10 6.5 3.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) DUF4172 PF13776.6 KOS20485.1 - 1.3 9.4 6.7 15 6.0 0.3 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF4172) LMBR1 PF04791.16 KOS20485.1 - 1.3 7.8 14.8 2.5 6.9 14.8 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein VitD-bind_III PF09164.10 KOS20485.1 - 1.4 9.0 15.3 24 5.0 0.2 5.0 1 1 4 5 5 5 0 Vitamin D binding protein, domain III YjbH PF06082.11 KOS20485.1 - 1.6 7.4 10.4 1.9 7.2 10.4 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH CorA PF01544.18 KOS20485.1 - 1.7 7.9 9.9 1.9 7.7 7.8 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein T2SSG PF08334.11 KOS20485.1 - 1.7 8.7 4.5 20 5.3 0.5 2.9 1 1 1 3 3 3 0 Type II secretion system (T2SS), protein G PCRF PF03462.18 KOS20485.1 - 2 8.2 16.6 18 5.1 1.9 2.2 1 1 1 2 2 2 0 PCRF domain LPP PF04728.13 KOS20485.1 - 2.2 8.7 16.0 23 5.5 0.1 5.0 2 1 0 2 2 1 0 Lipoprotein leucine-zipper ACP_PD PF04336.12 KOS20485.1 - 2.4 8.6 6.2 3.1 8.3 1.2 2.8 1 1 3 4 4 4 0 Acyl carrier protein phosphodiesterase MAS20 PF02064.15 KOS20485.1 - 2.5 8.2 15.1 2.4e+02 1.8 0.1 3.1 1 1 1 2 2 1 0 MAS20 protein import receptor DUF5085 PF16895.5 KOS20485.1 - 2.5 8.4 6.0 82 3.5 0.1 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF5085) T3SS_needle_F PF09392.10 KOS20485.1 - 3.1 8.1 15.7 20 5.5 0.5 4.7 1 1 4 5 5 5 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF VSG_B PF13206.6 KOS20485.1 - 3.4 6.8 13.1 4.6 6.4 13.1 1.3 1 0 0 1 1 1 0 Trypanosomal VSG domain DUF3422 PF11902.8 KOS20485.1 - 3.5 6.6 17.6 1 8.4 6.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3422) DUF2203 PF09969.9 KOS20485.1 - 4 8.2 14.8 5.6 7.7 1.2 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) FixO PF02433.15 KOS20485.1 - 4.4 6.7 9.7 1.6 8.1 0.7 2.1 1 1 1 2 2 2 0 Cytochrome C oxidase, mono-heme subunit/FixO FlaC_arch PF05377.11 KOS20485.1 - 5.7 7.4 8.1 15 6.1 0.1 4.1 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 KOS20485.1 - 6.3 7.1 18.8 11 6.3 2.6 3.8 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) LPP20 PF02169.16 KOS20485.1 - 8.5 6.8 19.3 15 6.0 5.9 3.1 1 1 1 2 2 2 0 LPP20 lipoprotein PI-PLC-X PF00388.19 KOS20486.1 - 5.3e-06 26.1 0.0 1.1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain Solute_trans_a PF03619.16 KOS20487.1 - 2.4e-80 269.9 25.9 2.8e-80 269.7 25.9 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Gln-synt_C PF00120.24 KOS20488.1 - 2.5e-71 240.5 0.0 1.2e-70 238.3 0.0 1.9 2 0 0 2 2 2 1 Glutamine synthetase, catalytic domain Amidohydro_2 PF04909.14 KOS20488.1 - 4.6e-17 62.7 0.0 1.3e-16 61.3 0.0 1.8 1 1 0 1 1 1 1 Amidohydrolase p450 PF00067.22 KOS20489.1 - 4e-53 180.8 0.0 6e-53 180.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 IF-2B PF01008.17 KOS20490.1 - 8.3e-43 146.6 0.0 1.1e-42 146.2 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Molybdopterin PF00384.22 KOS20493.1 - 1.3e-73 248.4 0.0 1.3e-71 241.8 0.0 2.2 1 1 0 1 1 1 1 Molybdopterin oxidoreductase Fer2_4 PF13510.6 KOS20493.1 - 1.4e-20 73.1 0.4 4.9e-20 71.4 0.4 2.0 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH_dhqG_C PF09326.11 KOS20493.1 - 6.5e-18 65.2 0.1 1.9e-17 63.7 0.1 1.9 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit G, C-terminal NADH-G_4Fe-4S_3 PF10588.9 KOS20493.1 - 4.2e-16 58.2 0.2 4.2e-16 58.2 0.2 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 KOS20493.1 - 2.2e-08 34.0 0.6 2.2e-08 34.0 0.6 2.1 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain TPP_enzyme_M PF00205.22 KOS20493.1 - 0.0045 16.7 0.0 0.13 12.0 0.0 2.5 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain Fer4 PF00037.27 KOS20493.1 - 0.11 12.3 1.1 3.5 7.6 0.3 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain Lyx_isomer PF07385.12 KOS20493.1 - 0.16 11.2 0.0 0.3 10.3 0.0 1.3 1 0 0 1 1 1 0 D-lyxose isomerase Fer4_17 PF13534.6 KOS20493.1 - 1.2 9.7 4.3 0.38 11.3 0.8 2.0 2 0 0 2 2 2 0 4Fe-4S dicluster domain Cation_efflux PF01545.21 KOS20494.1 - 4.9e-16 59.1 6.2 7.2e-16 58.5 6.2 1.2 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 KOS20494.1 - 3.6e-05 23.8 0.0 6.1e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DMRL_synthase PF00885.19 KOS20495.1 - 5.6e-58 194.8 0.0 7.3e-58 194.4 0.0 1.1 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase TRP PF06011.12 KOS20496.1 - 1e-40 139.8 20.9 2.8e-39 135.1 20.9 2.0 1 1 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOS20496.1 - 0.00024 21.5 0.1 0.00037 20.9 0.1 1.3 1 0 0 1 1 1 1 ML-like domain RNase_T PF00929.24 KOS20497.1 - 2.4e-09 37.9 0.0 1.4e-08 35.4 0.0 2.0 1 1 0 1 1 1 1 Exonuclease Cofilin_ADF PF00241.20 KOS20498.1 - 1.1e-36 125.3 0.5 1.2e-36 125.1 0.5 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2321 PF10083.9 KOS20498.1 - 0.24 11.0 1.9 4.1 7.0 0.1 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) HET PF06985.11 KOS20499.1 - 1.8e-18 67.3 0.0 3.1e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) MRP-S33 PF08293.11 KOS20500.1 - 2e-30 104.9 0.1 2.3e-30 104.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 IBR PF01485.21 KOS20501.1 - 6.4e-12 45.5 54.5 2e-06 27.9 4.7 4.6 4 1 0 4 4 4 3 IBR domain, a half RING-finger domain zf-C3HC4_2 PF13923.6 KOS20501.1 - 0.024 14.5 4.0 0.024 14.5 4.0 5.1 4 1 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) DUF5572 PF17733.1 KOS20502.1 - 3.9e-16 58.6 0.5 1.1e-15 57.2 0.5 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5572) DUF4880 PF16220.5 KOS20502.1 - 0.1 12.5 0.6 0.1 12.5 0.6 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4880) Beta-lactamase PF00144.24 KOS20503.1 - 9.9e-52 176.2 1.4 1.1e-51 176.1 0.6 1.5 2 0 0 2 2 2 1 Beta-lactamase DUF3471 PF11954.8 KOS20503.1 - 1.7e-08 34.9 0.0 3.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3471) Cwf_Cwc_15 PF04889.12 KOS20503.1 - 1.8 8.3 7.7 2.6 7.7 7.7 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Uds1 PF15456.6 KOS20504.1 - 3e-33 114.8 8.3 3e-33 114.8 8.3 6.5 2 1 4 6 6 6 1 Up-regulated During Septation CENP-F_leu_zip PF10473.9 KOS20504.1 - 9.8e-05 22.4 4.0 9.8e-05 22.4 4.0 8.7 6 2 2 9 9 8 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD PF14073.6 KOS20504.1 - 0.00019 21.5 11.7 0.00019 21.5 11.7 4.9 3 1 1 4 4 3 1 Centrosome localisation domain of Cep57 MscS_porin PF12795.7 KOS20504.1 - 0.0021 17.7 4.3 0.0021 17.7 4.3 7.0 3 1 3 6 6 5 2 Mechanosensitive ion channel porin domain Tropomyosin PF00261.20 KOS20504.1 - 0.0045 16.4 10.9 0.0045 16.4 10.9 7.7 4 2 3 7 7 7 1 Tropomyosin Bcr-Abl_Oligo PF09036.10 KOS20504.1 - 0.0063 16.5 0.0 0.0063 16.5 0.0 5.5 5 1 1 6 6 5 1 Bcr-Abl oncoprotein oligomerisation domain Tropomyosin_1 PF12718.7 KOS20504.1 - 0.013 15.6 7.7 0.013 15.6 7.7 7.2 3 2 3 7 7 6 0 Tropomyosin like DUF16 PF01519.16 KOS20504.1 - 0.018 15.6 1.0 0.018 15.6 1.0 7.5 3 2 3 7 7 7 0 Protein of unknown function DUF16 HMG_box PF00505.19 KOS20504.1 - 0.035 14.5 0.2 0.13 12.7 0.2 2.0 1 0 0 1 1 1 0 HMG (high mobility group) box Phage_tail_NK PF16532.5 KOS20504.1 - 0.17 11.5 3.0 9 5.9 0.1 3.1 1 1 2 3 3 3 0 Sf6-type phage tail needle knob or tip of some Caudovirales DUF948 PF06103.11 KOS20504.1 - 0.49 10.7 6.7 4.2 7.7 0.0 4.8 3 2 3 6 6 6 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 KOS20504.1 - 2.3 8.6 70.8 0.12 12.8 0.9 6.5 2 1 4 6 6 6 0 Fez1 FlaC_arch PF05377.11 KOS20504.1 - 3.2 8.2 37.7 0.18 12.2 0.5 8.7 9 1 0 11 11 8 0 Flagella accessory protein C (FlaC) Fib_alpha PF08702.10 KOS20504.1 - 9.2 6.4 40.0 0.61 10.3 0.3 7.1 3 3 6 9 9 9 0 Fibrinogen alpha/beta chain family Tcp11 PF05794.13 KOS20505.1 - 1.2e-111 374.0 0.3 1.6e-111 373.5 0.3 1.2 1 0 0 1 1 1 1 T-complex protein 11 TFIID-18kDa PF02269.16 KOS20506.1 - 2.6e-18 65.8 0.1 3.9e-18 65.3 0.1 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 KOS20506.1 - 0.00023 21.6 0.2 0.0011 19.4 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 KOS20506.1 - 0.00033 20.6 0.0 0.00057 19.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 KOS20506.1 - 0.0024 18.1 1.0 0.029 14.7 0.0 2.3 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-T_C PF15511.6 KOS20506.1 - 0.017 15.3 0.2 0.046 13.8 0.1 1.7 2 0 0 2 2 2 0 Centromere kinetochore component CENP-T histone fold TFIID-31kDa PF02291.15 KOS20506.1 - 0.019 15.0 0.0 0.034 14.2 0.0 1.4 1 1 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit CENP-S PF15630.6 KOS20506.1 - 0.088 13.2 0.0 0.2 12.1 0.0 1.6 1 0 0 1 1 1 0 CENP-S protein TIP49 PF06068.13 KOS20507.1 - 6e-167 555.2 0.0 7.5e-167 554.9 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KOS20507.1 - 4.9e-26 90.6 0.2 1.5e-25 89.1 0.2 1.9 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA PF00004.29 KOS20507.1 - 1.7e-10 41.5 0.2 8.7e-07 29.4 0.1 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 KOS20507.1 - 6.6e-09 35.7 0.7 1.6e-06 27.9 0.0 2.6 3 0 0 3 3 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOS20507.1 - 9.4e-05 22.7 0.2 0.11 12.8 0.0 2.5 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOS20507.1 - 0.00051 20.5 0.2 0.0066 16.9 0.2 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 KOS20507.1 - 0.00076 19.8 0.1 0.0025 18.1 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 KOS20507.1 - 0.001 19.4 1.8 0.16 12.3 0.2 2.5 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOS20507.1 - 0.0039 17.2 0.1 0.13 12.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOS20507.1 - 0.0071 15.9 0.1 0.046 13.3 0.1 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS20507.1 - 0.012 16.2 0.0 0.03 14.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOS20507.1 - 0.02 14.2 0.2 0.062 12.6 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 KOS20507.1 - 0.027 14.2 0.0 1.7 8.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DnaB_C PF03796.15 KOS20507.1 - 0.03 13.7 0.0 0.062 12.6 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain IstB_IS21 PF01695.17 KOS20507.1 - 0.03 14.0 0.9 0.055 13.2 0.1 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 KOS20507.1 - 0.033 13.6 0.1 0.89 8.9 0.1 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 KOS20507.1 - 0.049 12.9 0.1 0.14 11.4 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 KOS20507.1 - 0.13 12.0 0.5 3.1 7.5 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_7 PF12775.7 KOS20507.1 - 0.15 11.6 0.1 0.41 10.1 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region PMP1_2 PF08114.11 KOS20509.1 - 0.027 14.2 3.9 0.027 14.2 3.9 1.5 1 1 1 2 2 2 0 ATPase proteolipid family PDR_CDR PF06422.12 KOS20509.1 - 0.057 13.3 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 CDR ABC transporter TMEM219 PF14940.6 KOS20509.1 - 0.097 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Transmembrane 219 HHV-5_US34A PF17087.5 KOS20509.1 - 0.28 11.3 3.1 0.33 11.1 1.8 1.7 1 1 1 2 2 2 0 Herpesvirus US34A protein family Sec61_beta PF03911.16 KOS20509.1 - 0.84 9.7 7.0 1.1 9.4 7.0 1.2 1 0 0 1 1 1 0 Sec61beta family DUF676 PF05057.14 KOS20510.1 - 0.00031 20.3 0.0 0.00059 19.4 0.0 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 KOS20510.1 - 0.014 15.1 0.2 0.18 11.4 0.2 2.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 KOS20510.1 - 0.033 13.9 0.0 0.4 10.4 0.0 2.0 2 0 0 2 2 2 0 PGAP1-like protein Palm_thioest PF02089.15 KOS20510.1 - 0.076 12.8 0.0 0.13 12.1 0.0 1.5 1 1 0 1 1 1 0 Palmitoyl protein thioesterase SR-25 PF10500.9 KOS20510.1 - 5.3 6.6 11.3 8.2 6.0 11.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Arrestin_N PF00339.29 KOS20511.1 - 5.5e-15 55.7 0.0 1.6e-09 38.0 0.0 3.2 3 0 0 3 3 3 3 Arrestin (or S-antigen), N-terminal domain Bul1_C PF04426.12 KOS20511.1 - 0.087 12.2 0.0 0.22 10.9 0.0 1.6 2 0 0 2 2 2 0 Bul1 C terminus SAM_2 PF07647.17 KOS20513.1 - 4e-13 49.3 0.0 8.3e-13 48.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_1 PF00018.28 KOS20513.1 - 7e-12 44.8 0.0 1.5e-11 43.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS20513.1 - 3.2e-11 42.9 0.0 6.5e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PH PF00169.29 KOS20513.1 - 1.4e-09 38.4 0.1 7.1e-08 32.9 0.0 3.3 3 1 0 3 3 3 1 PH domain SH3_2 PF07653.17 KOS20513.1 - 0.0001 21.9 0.0 0.00036 20.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain PH_11 PF15413.6 KOS20513.1 - 0.011 16.2 0.2 0.034 14.6 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain Forkhead PF00250.18 KOS20514.1 - 1.6e-14 53.9 0.0 2.9e-14 53.1 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 KOS20514.1 - 0.0003 21.1 0.0 0.00067 20.0 0.0 1.6 1 0 0 1 1 1 1 FHA domain Perilipin PF03036.16 KOS20516.1 - 0.039 13.0 1.7 0.045 12.8 1.7 1.1 1 0 0 1 1 1 0 Perilipin family DUF5327 PF17261.2 KOS20517.1 - 0.085 13.6 0.6 0.17 12.6 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5327) ORC6 PF05460.13 KOS20517.1 - 0.11 11.7 5.3 0.13 11.5 5.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Pox_Ag35 PF03286.14 KOS20517.1 - 0.66 9.7 9.7 0.81 9.4 9.7 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pol_alpha_B_N PF08418.10 KOS20517.1 - 1.3 8.9 7.3 1.5 8.7 7.3 1.1 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF1180 PF06679.12 KOS20517.1 - 1.9 8.9 8.0 2.5 8.5 8.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PBP1_TM PF14812.6 KOS20518.1 - 0.94 9.9 5.2 2 8.8 5.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GYF PF02213.16 KOS20519.1 - 1.1e-07 31.3 3.6 1.7e-07 30.8 2.7 1.8 2 0 0 2 2 2 1 GYF domain UFD1 PF03152.14 KOS20520.1 - 5e-66 221.4 0.0 6.1e-66 221.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 Ribonuc_red_lgN PF00317.21 KOS20522.1 - 0.15 12.1 0.0 0.16 12.0 0.0 1.2 1 1 0 1 1 1 0 Ribonucleotide reductase, all-alpha domain Ribosomal_60s PF00428.19 KOS20522.1 - 2.4 8.8 7.9 4.3 8.0 7.9 1.7 1 1 0 1 1 1 0 60s Acidic ribosomal protein RNA_polI_A34 PF08208.11 KOS20524.1 - 0.0073 16.4 3.5 0.011 15.9 3.5 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Porph_ging PF09697.10 KOS20524.1 - 0.014 15.9 0.2 0.023 15.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) Myc_N PF01056.18 KOS20524.1 - 0.02 14.8 0.2 0.026 14.4 0.2 1.1 1 0 0 1 1 1 0 Myc amino-terminal region ORC_WH_C PF18137.1 KOS20524.1 - 0.057 13.5 0.8 0.08 13.0 0.8 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Peptidase_S49_N PF08496.10 KOS20524.1 - 0.086 12.9 0.3 0.12 12.5 0.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CENP-N PF05238.13 KOS20524.1 - 0.12 11.6 0.8 0.15 11.4 0.8 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like FAM176 PF14851.6 KOS20524.1 - 0.24 11.1 3.3 0.34 10.6 3.3 1.2 1 0 0 1 1 1 0 FAM176 family TFIIE-A_C PF11521.8 KOS20524.1 - 0.83 10.0 7.7 1.4 9.3 7.7 1.3 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Ribosomal_60s PF00428.19 KOS20524.1 - 1.4 9.6 9.2 2.5 8.7 9.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Blt1 PF12754.7 KOS20525.1 - 1.3e-39 136.0 0.1 1.6e-39 135.7 0.1 1.1 1 0 0 1 1 1 1 Blt1 N-terminal domain Blt1_C PF17183.4 KOS20525.1 - 4.2e-13 48.7 0.1 6.9e-13 48.0 0.1 1.4 1 0 0 1 1 1 1 Get5 carboxyl domain ubiquitin PF00240.23 KOS20525.1 - 1.1e-05 25.0 0.0 1.8e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin family Cpn60_TCP1 PF00118.24 KOS20526.1 - 1.3e-86 291.3 11.2 2.4e-86 290.3 11.2 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rrf2 PF02082.20 KOS20526.1 - 0.071 13.5 0.1 0.19 12.1 0.1 1.8 1 0 0 1 1 1 0 Transcriptional regulator XRCC4 PF06632.12 KOS20528.1 - 1.1e-09 37.7 0.1 1.6e-09 37.1 0.1 1.2 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 TFIIA PF03153.13 KOS20528.1 - 0.0083 16.2 7.8 0.011 15.7 7.8 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CCDC106 PF15794.5 KOS20528.1 - 7.1 6.3 11.1 0.15 11.8 3.7 1.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 ACBP PF00887.19 KOS20529.1 - 2.3e-24 85.4 0.1 5.4e-24 84.2 0.0 1.7 2 0 0 2 2 2 1 Acyl CoA binding protein Utp12 PF04003.12 KOS20529.1 - 0.19 12.1 2.1 6.3 7.2 1.3 2.5 2 0 0 2 2 2 0 Dip2/Utp12 Family DUF4381 PF14316.6 KOS20529.1 - 1.5 9.0 9.5 0.51 10.6 2.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) TFIIA PF03153.13 KOS20530.1 - 0.28 11.2 12.4 0.33 10.9 12.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CPSF100_C PF13299.6 KOS20530.1 - 0.33 11.1 3.7 0.63 10.2 3.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Dicty_REP PF05086.12 KOS20530.1 - 0.46 8.4 1.3 2.1 6.3 2.8 1.3 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Spt20 PF12090.8 KOS20530.1 - 0.51 9.9 11.7 0.91 9.1 11.7 1.4 1 0 0 1 1 1 0 Spt20 family Med3 PF11593.8 KOS20530.1 - 1.2 8.2 18.1 0.023 13.9 11.3 1.5 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Endostatin PF06482.11 KOS20530.1 - 1.8 8.0 7.3 2.3 7.6 7.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 KOS20530.1 - 2.1 7.0 3.0 2.3 6.9 3.0 1.1 1 0 0 1 1 1 0 Presenilin WBP-1 PF11669.8 KOS20530.1 - 4.1 8.1 4.8 7.1 7.3 4.1 1.7 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF3464 PF11947.8 KOS20530.1 - 7.4 6.3 5.7 13 5.5 5.7 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Brix PF04427.18 KOS20531.1 - 8e-43 146.8 0.0 1.1e-42 146.4 0.0 1.1 1 0 0 1 1 1 1 Brix domain UPF0061 PF02696.14 KOS20532.1 - 9.4e-126 420.3 0.0 1.2e-125 419.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family MFS_1 PF07690.16 KOS20533.1 - 5e-27 94.7 17.0 7.8e-27 94.1 17.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4231 PF14015.6 KOS20533.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF4231) DUF3405 PF11885.8 KOS20534.1 - 3.8e-207 689.0 4.4 9.4e-206 684.4 4.4 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF3405) CDT1_C PF16679.5 KOS20535.1 - 1.6e-22 79.7 0.1 1.6e-22 79.7 0.1 3.5 4 0 0 4 4 4 1 DNA replication factor Cdt1 C-terminal domain BCAS2 PF05700.11 KOS20536.1 - 4.9e-45 153.8 0.8 6.3e-45 153.4 0.8 1.1 1 0 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) ERM PF00769.19 KOS20536.1 - 0.068 13.0 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3438 PF11920.8 KOS20536.1 - 0.069 12.4 0.2 0.091 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) cNMP_binding PF00027.29 KOS20537.1 - 1.5e-39 134.0 0.0 5.2e-20 71.3 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain APC_r PF05923.12 KOS20537.1 - 0.15 11.9 0.6 0.96 9.3 0.1 2.6 2 0 0 2 2 2 0 APC repeat DUF3948 PF13134.6 KOS20537.1 - 0.18 11.6 0.0 0.37 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3948) Transketolase_N PF00456.21 KOS20538.1 - 5.6e-155 515.3 0.0 7.5e-155 514.9 0.0 1.2 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 KOS20538.1 - 2.5e-46 157.6 0.0 4.1e-46 156.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 KOS20538.1 - 3.9e-10 39.7 0.0 7.5e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 KOS20538.1 - 0.0018 17.5 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase ThiP_synth PF10120.9 KOS20538.1 - 0.0063 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Thiamine-phosphate synthase Glyco_hydro_20 PF00728.22 KOS20539.1 - 1.1e-82 278.2 0.0 1.4e-82 277.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Asp PF00026.23 KOS20539.1 - 1.4e-24 87.2 0.0 1.9e-24 86.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Glycohydro_20b2 PF14845.6 KOS20539.1 - 1.6e-20 74.1 0.0 2.9e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 KOS20539.1 - 0.06 14.1 0.0 0.15 12.9 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 TAXi_N PF14543.6 KOS20539.1 - 0.11 12.8 1.0 0.21 11.8 1.0 1.5 1 0 0 1 1 1 0 Xylanase inhibitor N-terminal FUSC_2 PF13515.6 KOS20540.1 - 1.6e-24 86.4 5.9 1.6e-24 86.4 5.9 3.1 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 KOS20540.1 - 1.5e-06 27.0 3.4 1.5e-06 27.0 3.4 2.3 3 0 0 3 3 3 1 Fusaric acid resistance protein family ALMT PF11744.8 KOS20540.1 - 0.00025 20.0 4.4 0.00025 20.0 4.4 3.6 4 1 0 4 4 4 1 Aluminium activated malate transporter ArAE_2 PF10334.9 KOS20540.1 - 0.029 14.2 0.0 0.09 12.6 0.0 1.7 2 0 0 2 2 2 0 Aromatic acid exporter family member 2 Phage_holin_Dp1 PF16938.5 KOS20540.1 - 0.16 12.2 0.0 0.16 12.2 0.0 3.3 4 0 0 4 4 4 0 Putative phage holin Dp-1 Peptidase_S8 PF00082.22 KOS20541.1 - 3.8e-11 42.8 0.0 8.8e-11 41.6 0.0 1.5 1 1 0 1 1 1 1 Subtilase family Ank PF00023.30 KOS20541.1 - 0.0074 16.7 0.0 0.02 15.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeat GHMP_kinases_N PF00288.26 KOS20541.1 - 0.017 15.4 0.6 0.039 14.2 0.6 1.6 1 0 0 1 1 1 0 GHMP kinases N terminal domain Ank_3 PF13606.6 KOS20541.1 - 0.034 14.7 0.0 0.9 10.3 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 KOS20541.1 - 0.14 12.8 0.0 0.44 11.2 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) MFS_1 PF07690.16 KOS20542.1 - 1.1e-22 80.4 58.4 6.1e-22 78.0 24.3 2.7 2 1 1 3 3 3 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS20542.1 - 1.1e-07 31.1 14.2 1.1e-07 31.1 14.2 2.4 2 1 1 3 3 3 1 Sugar (and other) transporter DUF2976 PF11190.8 KOS20542.1 - 0.21 11.4 2.7 4.9 7.0 0.1 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2976) Gaa1 PF04114.14 KOS20542.1 - 2.9 6.8 13.0 1.6 7.6 6.8 2.2 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component tRNA-synt_1d PF00750.19 KOS20543.1 - 4e-102 341.7 1.0 5.3e-102 341.3 1.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 KOS20543.1 - 7.2e-27 93.9 0.2 1.7e-26 92.7 0.2 1.7 1 0 0 1 1 1 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 KOS20543.1 - 0.0014 19.1 0.0 0.0052 17.3 0.0 2.1 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain T7SS_ESX1_EccB PF05108.13 KOS20543.1 - 0.081 11.6 0.0 0.15 10.7 0.0 1.3 1 0 0 1 1 1 0 Type VII secretion system ESX-1, transport TM domain B TauD PF02668.16 KOS20546.1 - 6.5e-59 199.9 2.0 8e-59 199.6 2.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family Methyltransf_25 PF13649.6 KOS20547.1 - 3.1e-16 59.9 0.0 1e-15 58.2 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS20547.1 - 2.7e-15 56.6 0.0 3.8e-15 56.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS20547.1 - 1e-12 48.1 0.0 1.4e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS20547.1 - 1.3e-12 48.2 0.0 2.6e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS20547.1 - 6e-12 46.2 0.0 9.6e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOS20547.1 - 1.2e-05 24.9 0.0 1.8e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_19 PF04672.12 KOS20547.1 - 1.6e-05 24.6 0.0 2.1e-05 24.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl methyltransferase FtsJ PF01728.19 KOS20547.1 - 2.1e-05 24.7 0.0 2.8e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF938 PF06080.12 KOS20547.1 - 0.00014 21.7 0.0 0.00021 21.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF938) Methyltransf_32 PF13679.6 KOS20547.1 - 0.0011 19.0 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain TPMT PF05724.11 KOS20547.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.2 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_4 PF02390.17 KOS20547.1 - 0.0021 17.5 0.0 0.0044 16.5 0.0 1.5 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 KOS20547.1 - 0.0052 16.1 0.0 0.0082 15.5 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 KOS20547.1 - 0.0084 15.9 0.0 0.014 15.1 0.0 1.5 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_24 PF13578.6 KOS20547.1 - 0.01 16.8 0.0 0.052 14.6 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase domain DOT1 PF08123.13 KOS20547.1 - 0.039 13.5 0.0 0.052 13.1 0.0 1.1 1 0 0 1 1 1 0 Histone methylation protein DOT1 CMAS PF02353.20 KOS20547.1 - 0.048 12.9 0.0 0.075 12.3 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_33 PF10017.9 KOS20547.1 - 0.062 12.4 0.0 0.15 11.1 0.0 1.6 2 0 0 2 2 2 0 Histidine-specific methyltransferase, SAM-dependent TehB PF03848.14 KOS20547.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB CheR PF01739.18 KOS20547.1 - 0.14 11.6 0.0 12 5.3 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Glyco_hydro_3 PF00933.21 KOS20548.1 - 4.9e-81 272.6 0.0 7.1e-81 272.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain SIS PF01380.22 KOS20548.1 - 0.016 15.1 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 SIS domain DUF3848 PF12959.7 KOS20548.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3848) Pmp3 PF01679.17 KOS20549.1 - 4.5e-20 71.6 8.5 7.5e-20 70.9 8.5 1.4 1 0 0 1 1 1 1 Proteolipid membrane potential modulator TFIIA PF03153.13 KOS20549.1 - 0.47 10.4 18.5 0.57 10.1 18.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 KOS20549.1 - 0.65 11.0 5.0 9.7 7.2 7.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 KOS20549.1 - 1.1 7.9 2.6 1.4 7.6 2.6 1.2 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 KOS20549.1 - 1.9 8.1 18.7 2.9 7.4 18.7 1.2 1 0 0 1 1 1 0 Spt20 family Ank_2 PF12796.7 KOS20550.1 - 1.6e-19 70.3 1.5 2e-05 25.1 0.1 6.6 5 1 2 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS20550.1 - 4.3e-18 65.4 2.7 1.1e-05 25.9 0.0 7.7 6 2 2 8 8 8 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS20550.1 - 1.2e-15 57.3 6.4 1.9e-05 24.8 0.2 6.6 6 1 1 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS20550.1 - 2.7e-14 51.9 2.5 0.3 11.8 0.0 8.4 9 0 0 9 9 9 3 Ankyrin repeat Ank PF00023.30 KOS20550.1 - 1.9e-09 37.5 9.1 0.03 14.8 0.0 7.1 7 0 0 7 7 7 3 Ankyrin repeat DUF3885 PF13021.6 KOS20550.1 - 0.089 12.9 0.0 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3885) HA2 PF04408.23 KOS20551.1 - 3.2e-23 82.1 0.1 3.2e-23 82.1 0.1 2.3 3 0 0 3 3 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOS20551.1 - 4.1e-21 75.1 0.0 8.2e-21 74.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOS20551.1 - 8.8e-14 51.8 0.0 2.2e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain S1 PF00575.23 KOS20551.1 - 2.1e-09 37.6 0.3 4.2e-09 36.6 0.3 1.5 1 0 0 1 1 1 1 S1 RNA binding domain AAA_22 PF13401.6 KOS20551.1 - 4.2e-06 27.1 0.0 1.1e-05 25.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOS20551.1 - 5.2e-05 22.4 0.3 0.00031 19.9 0.0 2.2 3 0 0 3 3 3 1 Type II/IV secretion system protein AAA_30 PF13604.6 KOS20551.1 - 8.5e-05 22.3 0.1 0.00045 20.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 KOS20551.1 - 0.00012 21.9 1.8 0.00025 20.9 0.5 2.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_19 PF13245.6 KOS20551.1 - 0.0099 16.2 0.1 0.023 15.0 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 KOS20551.1 - 0.01 15.9 0.5 0.12 12.5 0.1 2.5 2 1 0 2 2 1 0 AAA domain DUF2075 PF09848.9 KOS20551.1 - 0.036 13.3 0.0 0.062 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Microtub_bd PF16796.5 KOS20551.1 - 0.041 13.8 0.1 5.7 6.9 0.0 2.5 2 0 0 2 2 2 0 Microtubule binding ABC_tran PF00005.27 KOS20551.1 - 0.095 13.2 0.2 0.63 10.5 0.1 2.5 1 1 0 2 2 2 0 ABC transporter PhoH PF02562.16 KOS20551.1 - 0.095 12.1 0.2 0.33 10.4 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_16 PF13191.6 KOS20551.1 - 0.1 13.0 0.0 0.38 11.1 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain TrwB_AAD_bind PF10412.9 KOS20551.1 - 0.18 10.7 0.1 0.36 9.7 0.1 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain GCP_N_terminal PF17681.1 KOS20552.1 - 1.8e-26 93.5 0.0 3e-26 92.8 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 KOS20552.1 - 5.7e-20 72.0 0.0 9.4e-16 58.1 0.0 2.2 2 0 0 2 2 2 2 Gamma tubulin complex component C-terminal Ndc1_Nup PF09531.10 KOS20553.1 - 6 5.4 12.3 77 1.8 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Methyltransf_33 PF10017.9 KOS20554.1 - 6.4e-80 268.6 0.0 1.3e-79 267.6 0.0 1.5 2 0 0 2 2 2 1 Histidine-specific methyltransferase, SAM-dependent FGE-sulfatase PF03781.16 KOS20554.1 - 2.4e-19 69.9 0.1 4.3e-18 65.8 0.1 2.4 1 1 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 DinB_2 PF12867.7 KOS20554.1 - 2.1e-06 28.3 1.9 1.1e-05 25.9 1.4 2.5 2 1 0 2 2 2 1 DinB superfamily Senescence PF06911.12 KOS20555.1 - 5.8e-56 189.7 2.1 8.6e-56 189.2 2.1 1.3 1 0 0 1 1 1 1 Senescence-associated protein Med21 PF11221.8 KOS20555.1 - 0.28 11.4 0.7 0.56 10.5 0.4 1.7 1 1 0 1 1 1 0 Subunit 21 of Mediator complex Arb1 PF09692.10 KOS20556.1 - 2.6e-106 356.2 0.0 3.1e-106 355.9 0.0 1.0 1 0 0 1 1 1 1 Argonaute siRNA chaperone (ARC) complex subunit Arb1 Glutaredoxin PF00462.24 KOS20557.1 - 2e-13 50.3 0.0 4.6e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin DUF4148 PF13663.6 KOS20557.1 - 0.12 12.5 2.2 0.4 10.9 2.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4148) GCIP PF13324.6 KOS20557.1 - 0.14 11.8 3.9 0.19 11.3 0.3 2.1 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Menin PF05053.13 KOS20557.1 - 0.15 10.4 4.8 0.2 10.0 4.8 1.1 1 0 0 1 1 1 0 Menin PPP4R2 PF09184.11 KOS20557.1 - 0.55 9.8 8.1 0.82 9.2 8.1 1.2 1 0 0 1 1 1 0 PPP4R2 PBP1_TM PF14812.6 KOS20557.1 - 0.84 10.0 11.4 0.33 11.4 2.9 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal STAC2_u1 PF16664.5 KOS20557.1 - 1.4 9.4 5.4 0.48 10.9 0.5 2.2 2 0 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 SIL1 PF16782.5 KOS20558.1 - 0.0066 15.7 0.0 0.078 12.2 0.0 1.9 2 0 0 2 2 2 2 Nucleotide exchange factor SIL1 zf-MYND PF01753.18 KOS20559.1 - 1.3e-07 31.5 14.0 1.3e-07 31.5 14.0 2.1 2 0 0 2 2 2 1 MYND finger SET PF00856.28 KOS20559.1 - 8.1e-07 29.6 0.0 3.3e-06 27.6 0.0 2.1 1 1 0 1 1 1 1 SET domain FlaC_arch PF05377.11 KOS20560.1 - 0.00064 20.1 8.2 0.16 12.3 0.2 5.4 5 1 1 6 6 6 1 Flagella accessory protein C (FlaC) AAA_13 PF13166.6 KOS20560.1 - 0.00076 18.3 4.7 0.016 13.9 0.2 2.2 1 1 1 2 2 2 1 AAA domain Fib_alpha PF08702.10 KOS20560.1 - 0.00096 19.4 6.1 3.7 7.7 0.3 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TolA_bind_tri PF16331.5 KOS20560.1 - 0.0015 18.6 2.9 0.0015 18.6 2.9 5.1 5 0 0 5 5 5 1 TolA binding protein trimerisation NUDE_C PF04880.13 KOS20560.1 - 0.002 18.6 2.6 0.002 18.6 2.6 2.5 2 1 1 3 3 3 1 NUDE protein, C-terminal conserved region GOLGA2L5 PF15070.6 KOS20560.1 - 0.0023 16.7 10.3 0.014 14.1 2.2 2.2 1 1 1 2 2 2 2 Putative golgin subfamily A member 2-like protein 5 T3SSipB PF16535.5 KOS20560.1 - 0.0029 18.1 4.2 0.0029 18.1 4.2 2.1 2 0 0 2 2 1 1 Type III cell invasion protein SipB Y_phosphatase3 PF13350.6 KOS20560.1 - 0.0034 17.4 0.3 0.011 15.8 0.0 1.8 1 1 0 1 1 1 1 Tyrosine phosphatase family ATG16 PF08614.11 KOS20560.1 - 0.0044 17.3 12.3 0.0044 17.3 12.3 2.6 2 1 1 3 3 2 2 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 KOS20560.1 - 0.0046 17.0 13.7 0.53 10.3 1.7 3.7 2 1 0 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.10 KOS20560.1 - 0.0052 17.2 7.0 0.0052 17.2 7.0 4.0 2 1 1 3 3 2 1 Bacterial type III secretion protein (HrpB7) YabA PF06156.13 KOS20560.1 - 0.0064 17.1 8.7 0.82 10.3 0.6 3.8 1 1 3 4 4 4 2 Initiation control protein YabA Fez1 PF06818.15 KOS20560.1 - 0.0092 16.4 5.4 0.0092 16.4 5.4 2.6 2 1 1 3 3 2 1 Fez1 RPW8 PF05659.11 KOS20560.1 - 0.016 14.9 1.1 21 4.8 0.0 3.5 3 1 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ISG65-75 PF11727.8 KOS20560.1 - 0.02 14.1 1.4 0.042 13.1 0.6 1.8 2 0 0 2 2 2 0 Invariant surface glycoprotein EzrA PF06160.12 KOS20560.1 - 0.025 12.8 7.8 0.27 9.3 0.4 2.8 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA Filament PF00038.21 KOS20560.1 - 0.044 13.4 17.7 0.023 14.3 6.4 2.9 2 1 0 3 3 3 0 Intermediate filament protein BicD PF09730.9 KOS20560.1 - 0.047 12.1 5.4 0.083 11.3 5.4 1.4 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D GAS PF13851.6 KOS20560.1 - 0.058 12.8 9.5 0.17 11.2 6.8 2.7 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding PspA_IM30 PF04012.12 KOS20560.1 - 0.11 12.1 17.7 0.031 13.8 7.8 2.9 3 1 0 3 3 2 0 PspA/IM30 family LMBR1 PF04791.16 KOS20560.1 - 0.16 10.9 0.3 0.2 10.5 0.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 KOS20560.1 - 0.19 11.1 11.3 0.9 8.8 11.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 KOS20560.1 - 0.29 11.1 6.7 1.3 9.0 1.1 2.7 1 1 0 2 2 2 0 Laminin Domain II HAP1_N PF04849.13 KOS20560.1 - 0.42 9.8 12.3 0.27 10.4 2.3 2.5 1 1 0 2 2 2 0 HAP1 N-terminal conserved region Spc24 PF08286.11 KOS20560.1 - 0.47 10.7 6.8 1.4 9.2 0.7 3.6 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 THOC7 PF05615.13 KOS20560.1 - 0.48 10.7 20.8 1.7 9.0 4.6 4.3 3 1 1 4 4 4 0 Tho complex subunit 7 zf-C4H2 PF10146.9 KOS20560.1 - 0.69 10.2 6.3 0.11 12.7 0.5 2.2 1 1 1 2 2 2 0 Zinc finger-containing protein DUF1664 PF07889.12 KOS20560.1 - 0.74 9.9 8.9 9.2 6.3 2.0 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) V_ATPase_I_N PF18670.1 KOS20560.1 - 0.78 10.2 7.6 0.19 12.1 2.3 2.6 3 0 0 3 3 2 0 V-type ATPase subunit I, N-terminal domain Leu_zip PF15294.6 KOS20560.1 - 0.88 9.0 7.7 0.86 9.1 1.0 2.4 2 1 1 3 3 3 0 Leucine zipper SKA1 PF07160.12 KOS20560.1 - 0.97 9.2 7.0 6.7 6.5 1.2 2.7 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 Alanine_zipper PF11839.8 KOS20560.1 - 1 9.8 7.4 14 6.1 4.8 3.0 1 1 1 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DUF812 PF05667.11 KOS20560.1 - 1.1 8.0 11.8 0.17 10.7 7.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF812) DUF4795 PF16043.5 KOS20560.1 - 1.3 8.6 7.1 3.6 7.1 7.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) KASH_CCD PF14662.6 KOS20560.1 - 1.4 8.8 12.7 0.19 11.6 2.9 2.9 3 0 0 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF5082 PF16888.5 KOS20560.1 - 1.4 9.2 8.5 3.2 8.0 1.4 3.5 3 2 0 3 3 3 0 Domain of unknown function (DUF5082) PRKG1_interact PF15898.5 KOS20560.1 - 1.5 9.8 16.3 2.1 9.3 5.0 4.0 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain OmpH PF03938.14 KOS20560.1 - 1.8 8.9 22.3 0.11 12.8 5.0 3.4 3 1 0 3 3 3 0 Outer membrane protein (OmpH-like) UPF0242 PF06785.11 KOS20560.1 - 2.4 8.2 10.9 1.7 8.7 3.4 2.6 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 KOS20560.1 - 2.4 8.4 17.3 5 7.4 1.3 4.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF4686 PF15742.5 KOS20560.1 - 2.7 7.0 13.6 0.78 8.8 10.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4686) DUF4472 PF14739.6 KOS20560.1 - 2.9 8.7 10.3 2.3 9.0 1.3 3.2 3 1 0 3 3 2 0 Domain of unknown function (DUF4472) Spc7 PF08317.11 KOS20560.1 - 3.8 6.3 16.9 3.6 6.4 6.1 2.7 2 1 1 3 3 3 0 Spc7 kinetochore protein SlyX PF04102.12 KOS20560.1 - 4.3 8.0 25.3 9.3 6.9 4.1 5.1 5 1 0 5 5 4 0 SlyX DUF2353 PF09789.9 KOS20560.1 - 4.3 6.6 14.7 20 4.4 2.3 2.3 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DLP_helical PF18709.1 KOS20560.1 - 5.9 6.0 8.7 9.3 5.3 0.7 2.7 2 1 0 2 2 2 0 Dynamin-like helical domain DUF4618 PF15397.6 KOS20560.1 - 7.6 5.9 11.6 2.3 7.6 2.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4618) Atg14 PF10186.9 KOS20560.1 - 7.7 5.5 16.9 3.7e+02 -0.0 16.5 2.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GrpE PF01025.19 KOS20560.1 - 9.8 5.8 8.4 2.7 7.6 0.4 3.1 3 1 1 4 4 4 0 GrpE TPR_1 PF00515.28 KOS20561.1 - 2e-22 78.0 8.6 3.9e-07 29.6 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20561.1 - 4.4e-22 76.4 13.2 1.2e-06 28.1 0.0 7.3 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS20561.1 - 2.3e-18 65.6 5.6 4.6e-08 32.6 0.0 5.4 3 3 2 5 5 5 3 TPR repeat TPR_14 PF13428.6 KOS20561.1 - 1.1e-15 56.9 13.0 2.3e-05 24.8 0.0 6.8 5 1 2 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20561.1 - 1.3e-15 57.8 14.9 9.9e-05 22.9 0.0 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS20561.1 - 1.2e-14 53.2 8.0 3.3e-06 26.9 0.0 6.5 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOS20561.1 - 1e-13 50.6 2.7 0.048 14.1 0.0 5.4 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 KOS20561.1 - 1.1e-12 48.2 14.9 0.0012 19.3 0.6 6.2 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOS20561.1 - 6.1e-11 41.6 4.1 0.0048 16.8 0.0 5.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS20561.1 - 9.8e-08 32.0 3.3 0.0069 16.5 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOS20561.1 - 1.9e-07 31.3 10.5 2.6 8.9 0.1 7.5 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS20561.1 - 1.3e-06 28.6 6.6 0.00018 21.7 0.2 4.9 3 1 3 6 6 5 4 Tetratricopeptide repeat TPR_15 PF13429.6 KOS20561.1 - 0.00011 21.5 9.4 0.073 12.3 0.1 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TFIIA PF03153.13 KOS20561.1 - 0.00012 22.2 18.7 0.0002 21.5 18.7 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TPR_20 PF14561.6 KOS20561.1 - 0.00047 20.4 14.7 0.026 14.8 0.1 5.0 4 3 2 6 6 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS20561.1 - 0.0053 17.0 3.0 2.3 8.5 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF1641 PF07849.11 KOS20561.1 - 0.13 12.2 0.2 0.24 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1641) TPR_10 PF13374.6 KOS20561.1 - 0.18 11.7 0.2 0.18 11.7 0.2 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat G0-G1_switch_2 PF15103.6 KOS20561.1 - 0.27 11.7 4.2 0.29 11.6 2.5 1.9 1 1 1 2 2 2 0 G0/G1 switch protein 2 DUF2370 PF10176.9 KOS20561.1 - 0.58 9.8 3.1 1.1 8.9 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) TPR_3 PF07720.12 KOS20561.1 - 1.1 9.3 6.3 16 5.6 0.1 4.3 5 0 0 5 5 3 0 Tetratricopeptide repeat Spt20 PF12090.8 KOS20561.1 - 1.2 8.6 21.1 2.5 7.6 21.1 1.4 1 0 0 1 1 1 0 Spt20 family FHIPEP PF00771.20 KOS20561.1 - 1.9 6.9 5.0 2.8 6.3 5.0 1.1 1 0 0 1 1 1 0 FHIPEP family Ferritin_2 PF13668.6 KOS20562.1 - 1.6e-16 60.7 0.0 2.6e-16 60.1 0.0 1.3 1 0 0 1 1 1 1 Ferritin-like domain HLH PF00010.26 KOS20563.1 - 7.4e-13 48.2 0.6 1.5e-12 47.2 0.6 1.5 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain NRBF2 PF08961.10 KOS20563.1 - 0.00031 20.4 2.7 0.00048 19.8 2.7 1.4 1 1 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator DUF4776 PF16003.5 KOS20563.1 - 0.014 14.4 0.7 0.017 14.2 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Phage_GPO PF05929.11 KOS20563.1 - 0.015 14.9 0.1 0.02 14.5 0.1 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase PRKG1_interact PF15898.5 KOS20563.1 - 0.29 12.1 0.1 0.29 12.1 0.1 2.2 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain SlyX PF04102.12 KOS20563.1 - 1.8 9.2 9.9 22 5.8 3.5 3.6 2 1 1 3 3 3 0 SlyX Zn_clus PF00172.18 KOS20564.1 - 1.6e-08 34.6 16.4 2.4e-08 33.9 16.4 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Radical_SAM PF04055.21 KOS20565.1 - 1.7e-13 51.3 0.4 3.4e-13 50.3 0.2 1.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 KOS20565.1 - 2.8e-07 30.9 0.2 6.7e-07 29.7 0.0 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 KOS20565.1 - 7.3e-06 26.1 0.1 2.1e-05 24.7 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S single cluster domain ADK PF00406.22 KOS20566.1 - 9.2e-26 90.8 0.0 1.1e-25 90.5 0.0 1.0 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOS20566.1 - 3.6e-19 69.5 0.0 4.3e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOS20566.1 - 1.4e-09 38.3 0.0 1.8e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOS20566.1 - 4.7e-09 36.9 0.0 7.1e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 KOS20566.1 - 0.00073 19.3 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase Thymidylate_kin PF02223.17 KOS20566.1 - 0.08 12.6 0.1 0.78 9.4 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase AAA PF00004.29 KOS20566.1 - 0.1 13.0 0.1 0.37 11.2 0.1 1.9 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 KOS20566.1 - 0.1 11.8 0.2 0.3 10.3 0.2 1.8 1 1 0 1 1 1 0 Zeta toxin VWA PF00092.28 KOS20567.1 - 5.2e-08 33.3 0.0 0.00069 19.9 0.0 2.1 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 KOS20567.1 - 0.0016 19.0 0.0 0.0059 17.2 0.0 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain Aminotran_1_2 PF00155.21 KOS20568.1 - 3e-36 125.4 0.0 4.1e-36 124.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II RRM_1 PF00076.22 KOS20569.1 - 2.9e-43 145.5 1.9 2.6e-20 72.0 0.1 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 KOS20569.1 - 4.2e-24 85.4 0.2 1.1e-23 84.1 0.2 1.8 1 0 0 1 1 1 1 linker between RRM2 and RRM3 domains in RBM39 protein Nup35_RRM_2 PF14605.6 KOS20569.1 - 0.0019 18.2 0.0 0.4 10.7 0.0 3.1 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KOS20569.1 - 0.0021 17.9 0.0 0.054 13.4 0.0 2.8 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_3 PF08777.11 KOS20569.1 - 0.0052 16.8 1.7 0.35 10.9 0.0 3.2 3 2 1 4 4 4 1 RNA binding motif PHM7_cyt PF14703.6 KOS20569.1 - 0.0063 16.8 0.2 0.21 11.8 0.2 3.2 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RRM_7 PF16367.5 KOS20569.1 - 0.018 15.1 0.0 1.4 9.1 0.0 2.5 2 0 0 2 2 2 0 RNA recognition motif RRM_5 PF13893.6 KOS20569.1 - 0.12 12.0 0.0 0.37 10.4 0.0 1.8 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Atrophin-1 PF03154.15 KOS20569.1 - 1.5 7.0 9.6 2.9 6.1 9.6 1.4 1 0 0 1 1 1 0 Atrophin-1 family PP_kinase PF02503.17 KOS20570.1 - 0.039 13.5 0.0 0.11 12.1 0.0 1.7 1 0 0 1 1 1 0 Polyphosphate kinase middle domain ZapB PF06005.12 KOS20570.1 - 0.26 11.7 10.0 0.6 10.6 5.5 2.8 1 1 1 2 2 2 0 Cell division protein ZapB CDP-OH_P_transf PF01066.21 KOS20571.1 - 4.1e-13 49.9 0.4 4.1e-13 49.9 0.4 2.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase OMPdecase PF00215.24 KOS20572.1 - 6.4e-104 346.5 0.0 7.6e-104 346.2 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family CYTH PF01928.21 KOS20573.1 - 5.3e-09 36.3 0.0 1.2e-08 35.2 0.0 1.4 1 1 0 1 1 1 1 CYTH domain Ribonuclease_3 PF00636.26 KOS20575.1 - 2e-15 57.3 0.0 6.5e-15 55.7 0.0 1.9 1 0 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 KOS20575.1 - 1.5e-09 38.1 0.0 4.2e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 KOS20575.1 - 0.015 16.0 0.0 0.046 14.4 0.0 1.9 1 0 0 1 1 1 0 Double-stranded RNA binding motif Staufen_C PF16482.5 KOS20575.1 - 0.088 13.0 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 Staufen C-terminal domain Med3 PF11593.8 KOS20575.1 - 0.59 9.3 5.7 0.78 8.9 2.2 2.0 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal PUF PF00806.19 KOS20576.1 - 3.2e-42 139.9 0.2 1.6e-06 27.5 0.0 8.9 9 0 0 9 9 9 8 Pumilio-family RNA binding repeat Phage_lambda_P PF06992.11 KOS20576.1 - 0.0061 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Replication protein P Epimerase PF01370.21 KOS20577.1 - 4.7e-14 52.4 0.0 7.1e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOS20577.1 - 1.3e-09 37.5 0.0 1.8e-09 37.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 KOS20577.1 - 2.6e-07 30.7 1.0 4.1e-07 30.1 0.3 1.8 2 0 0 2 2 2 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KOS20577.1 - 6.1e-05 22.3 0.2 0.1 11.7 0.3 2.1 2 0 0 2 2 2 2 Male sterility protein GDP_Man_Dehyd PF16363.5 KOS20577.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase KR PF08659.10 KOS20577.1 - 0.015 15.2 0.1 0.051 13.5 0.0 1.9 2 1 0 2 2 2 0 KR domain NmrA PF05368.13 KOS20577.1 - 0.029 13.9 0.0 0.048 13.2 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Polysacc_synt_2 PF02719.15 KOS20577.1 - 0.067 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Nfu_N PF08712.11 KOS20577.1 - 0.16 12.0 0.0 21 5.3 0.0 2.4 2 0 0 2 2 2 0 Scaffold protein Nfu/NifU N terminal DUF5437 PF17505.2 KOS20577.1 - 0.93 9.6 3.9 2.7 8.1 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5437) PP2C PF00481.21 KOS20578.1 - 4.7e-42 144.4 0.0 7.7e-42 143.7 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOS20578.1 - 0.0066 16.4 0.0 0.19 11.6 0.0 2.3 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 KOS20578.1 - 0.01 15.5 0.0 0.021 14.5 0.0 1.5 1 1 0 1 1 1 0 Protein phosphatase 2C Rhomboid PF01694.22 KOS20579.1 - 1.4e-06 28.4 2.1 3.1e-06 27.3 2.1 1.5 1 1 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 KOS20579.1 - 1.5e-05 25.5 0.3 2.7e-05 24.6 0.3 1.4 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) DER1 PF04511.15 KOS20579.1 - 0.0087 16.0 2.2 0.013 15.4 2.2 1.2 1 0 0 1 1 1 1 Der1-like family Gly-zipper_OmpA PF13436.6 KOS20579.1 - 1.2 9.0 10.4 7.2 6.5 0.2 2.5 2 0 0 2 2 2 0 Glycine-zipper domain Acid_PPase PF12689.7 KOS20580.1 - 2.3e-55 187.0 0.0 3.1e-55 186.6 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase LRV PF01816.17 KOS20580.1 - 8 7.1 8.8 0.43 11.1 2.1 2.5 2 0 0 2 2 2 0 Leucine rich repeat variant CRAL_TRIO PF00650.20 KOS20581.1 - 4e-24 85.1 0.0 5.8e-24 84.6 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOS20581.1 - 4.7e-08 33.1 0.1 9.9e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CLP1_P PF16575.5 KOS20582.1 - 3.9e-26 92.0 0.0 6.8e-26 91.2 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 KOS20582.1 - 1.9e-25 88.9 0.0 3.3e-25 88.1 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 KOS20582.1 - 8.8e-24 84.2 0.1 1.3e-21 77.2 0.1 2.4 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 AAA_16 PF13191.6 KOS20582.1 - 3.4e-07 30.8 0.8 8.6e-07 29.5 0.8 1.7 1 1 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 KOS20582.1 - 9.6e-07 28.9 0.0 2.4e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 KOS20582.1 - 4.2e-06 26.7 0.1 1.4e-05 25.0 0.1 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA PF00004.29 KOS20582.1 - 0.0004 20.8 0.1 0.0013 19.2 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS20582.1 - 0.00048 19.9 0.0 0.00084 19.1 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain MeaB PF03308.16 KOS20582.1 - 0.00062 18.8 0.9 0.0014 17.7 0.9 1.5 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 KOS20582.1 - 0.0015 18.0 0.1 0.0028 17.1 0.1 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_22 PF13401.6 KOS20582.1 - 0.0017 18.6 0.0 0.0037 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOS20582.1 - 0.0019 17.6 0.0 0.0039 16.6 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_18 PF13238.6 KOS20582.1 - 0.0022 18.5 0.0 0.0043 17.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOS20582.1 - 0.0027 18.0 0.0 0.007 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOS20582.1 - 0.0033 16.5 0.1 0.0055 15.8 0.1 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_33 PF13671.6 KOS20582.1 - 0.0044 17.2 1.4 0.0055 16.9 0.1 1.9 2 0 0 2 2 1 1 AAA domain Zeta_toxin PF06414.12 KOS20582.1 - 0.0048 16.2 0.1 0.0092 15.3 0.1 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_30 PF13604.6 KOS20582.1 - 0.0048 16.6 2.9 0.01 15.6 2.9 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOS20582.1 - 0.0054 16.5 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein NACHT PF05729.12 KOS20582.1 - 0.0062 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_19 PF13245.6 KOS20582.1 - 0.0064 16.8 1.4 0.0093 16.3 0.5 1.7 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 KOS20582.1 - 0.0076 16.0 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain SnoaL PF07366.12 KOS20582.1 - 0.0077 16.0 0.0 0.19 11.6 0.0 2.2 2 0 0 2 2 2 1 SnoaL-like polyketide cyclase KTI12 PF08433.10 KOS20582.1 - 0.01 15.3 0.0 0.022 14.2 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 DUF815 PF05673.13 KOS20582.1 - 0.01 15.0 0.0 0.029 13.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_25 PF13481.6 KOS20582.1 - 0.011 15.3 0.3 0.033 13.8 0.1 1.9 2 0 0 2 2 1 0 AAA domain DAP3 PF10236.9 KOS20582.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RuvB_N PF05496.12 KOS20582.1 - 0.023 14.5 0.3 0.056 13.2 0.1 1.7 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KOS20582.1 - 0.033 13.7 0.1 0.052 13.0 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ArsA_ATPase PF02374.15 KOS20582.1 - 0.034 13.3 0.2 0.052 12.7 0.2 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase MobB PF03205.14 KOS20582.1 - 0.04 13.8 0.0 0.15 12.0 0.0 2.0 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 KOS20582.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF2075 PF09848.9 KOS20582.1 - 0.045 13.0 0.1 0.07 12.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DnaB_C PF03796.15 KOS20582.1 - 0.06 12.7 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain NTPase_1 PF03266.15 KOS20582.1 - 0.062 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 NTPase ABC_tran PF00005.27 KOS20582.1 - 0.067 13.7 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 KOS20582.1 - 0.068 13.3 2.5 0.14 12.3 0.0 2.8 3 1 0 3 3 2 0 50S ribosome-binding GTPase AAA_31 PF13614.6 KOS20582.1 - 0.071 13.0 0.1 0.14 12.0 0.1 1.5 1 1 0 1 1 1 0 AAA domain DUF853 PF05872.12 KOS20582.1 - 0.087 11.4 0.9 0.14 10.7 0.9 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Mg_chelatase PF01078.21 KOS20582.1 - 0.088 12.2 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 KOS20582.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 KOS20582.1 - 0.097 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_35 PF14516.6 KOS20582.1 - 0.099 11.5 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain PIF1 PF05970.14 KOS20582.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 PIF1-like helicase TsaE PF02367.17 KOS20582.1 - 0.12 12.4 0.2 0.22 11.5 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 KOS20582.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TrwB_AAD_bind PF10412.9 KOS20582.1 - 0.13 11.1 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 KOS20582.1 - 0.15 11.9 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 KOS20582.1 - 0.16 10.9 0.0 0.25 10.2 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain IPK PF03770.16 KOS20583.1 - 1.9e-46 158.5 0.0 2.7e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase Synaptobrevin PF00957.21 KOS20584.1 - 1.7e-31 107.9 0.4 2.5e-31 107.3 0.4 1.2 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 KOS20584.1 - 3.1e-28 97.6 0.0 5.4e-28 96.9 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain FixS PF03597.15 KOS20584.1 - 0.78 9.5 4.8 1.4 8.7 4.8 1.4 1 0 0 1 1 1 0 Cytochrome oxidase maturation protein cbb3-type SNARE PF05739.19 KOS20584.1 - 7.5 6.6 6.9 17 5.5 6.9 1.6 1 0 0 1 1 1 0 SNARE domain Fibin PF15819.5 KOS20585.1 - 0.18 11.5 0.3 0.37 10.5 0.3 1.5 1 0 0 1 1 1 0 Fin bud initiation factor homologue PI3_PI4_kinase PF00454.27 KOS20586.1 - 4.8e-38 131.4 0.1 2.8e-35 122.3 0.1 2.3 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 KOS20586.1 - 1.3e-18 67.0 0.1 2.5e-18 66.2 0.1 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) HATPase_c_3 PF13589.6 KOS20588.1 - 3e-14 53.0 0.1 5.4e-14 52.2 0.1 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 KOS20588.1 - 1.7e-11 43.8 0.0 3.1e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 KOS20588.1 - 3.5e-10 40.4 0.2 8.4e-10 39.1 0.1 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase TPR_12 PF13424.6 KOS20589.1 - 6.3e-12 45.6 13.6 2e-06 28.0 1.8 4.3 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS20589.1 - 1.4e-09 38.4 9.2 0.028 14.9 1.5 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOS20589.1 - 4.6e-07 30.1 13.6 0.35 11.8 0.4 5.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20589.1 - 5.8e-07 30.1 17.8 0.00091 19.8 3.7 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20589.1 - 4e-06 26.5 13.9 0.064 13.4 0.1 5.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS20589.1 - 5.7e-05 23.0 0.2 1.8 9.0 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS20589.1 - 0.00024 20.8 0.8 10 6.1 0.0 4.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS20589.1 - 0.00027 21.1 1.4 11 6.7 0.0 5.6 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS20589.1 - 0.00098 19.0 4.0 4.4 7.6 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOS20589.1 - 0.0079 16.0 16.7 0.84 9.6 0.1 5.1 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS20589.1 - 0.01 16.0 0.8 6.7 7.0 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 KOS20589.1 - 0.13 13.0 6.5 81 4.2 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat LPD15 PF18828.1 KOS20589.1 - 0.14 12.0 3.3 0.41 10.6 3.3 1.8 1 0 0 1 1 1 0 Large polyvalent-protein-associated domain 15 TPR_20 PF14561.6 KOS20589.1 - 1 9.8 6.7 10 6.6 1.2 3.4 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_9 PF13371.6 KOS20589.1 - 5.8 7.1 12.4 0.082 13.1 1.7 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat RWD PF05773.22 KOS20590.1 - 1.7e-18 67.0 0.0 5.2e-18 65.4 0.0 1.8 1 1 0 1 1 1 1 RWD domain DFRP_C PF16543.5 KOS20590.1 - 3.3e-06 27.5 3.2 5.8e-06 26.7 3.2 1.5 1 0 0 1 1 1 1 DRG Family Regulatory Proteins, Tma46 DUF2852 PF11014.8 KOS20590.1 - 0.0049 17.0 1.3 0.0073 16.5 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2852) zf-C3HC4 PF00097.25 KOS20592.1 - 1.4e-07 31.2 6.2 2.6e-07 30.4 6.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS20592.1 - 3.5e-07 30.2 1.4 3.5e-07 30.2 1.4 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS20592.1 - 3.2e-06 27.0 3.8 6e-06 26.1 3.8 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOS20592.1 - 6.4e-06 25.9 6.0 2.5e-05 24.0 2.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS20592.1 - 7.3e-06 25.8 5.7 1.8e-05 24.5 5.7 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS20592.1 - 9.9e-06 25.8 6.7 2.3e-05 24.6 6.7 1.6 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KOS20592.1 - 5.4e-05 23.3 5.4 0.0004 20.5 5.4 2.1 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KOS20592.1 - 0.029 14.2 9.9 0.44 10.4 9.8 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-ACC PF17848.1 KOS20592.1 - 0.18 11.9 0.2 0.44 10.7 0.2 1.7 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain zf-rbx1 PF12678.7 KOS20592.1 - 0.35 11.2 4.8 0.99 9.7 4.8 1.8 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_10 PF16685.5 KOS20592.1 - 0.38 10.9 3.9 0.17 12.1 1.4 1.6 2 0 0 2 2 1 0 zinc RING finger of MSL2 FYVE PF01363.21 KOS20592.1 - 0.55 10.4 3.0 1.4 9.1 3.0 1.7 1 1 0 1 1 1 0 FYVE zinc finger zf-C3HC4_5 PF17121.5 KOS20592.1 - 5.9 6.9 6.9 8.3 6.4 0.1 3.4 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 KOS20592.1 - 9.8 6.0 7.6 39 4.1 7.6 2.0 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger Mpp10 PF04006.12 KOS20593.1 - 7.3e-115 384.8 44.6 3.1e-104 349.6 3.5 2.1 1 1 1 2 2 2 2 Mpp10 protein TFIIA PF03153.13 KOS20593.1 - 0.0004 20.5 14.5 0.0004 20.5 14.5 3.2 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit SHNi-TPR PF10516.9 KOS20594.1 - 6.8e-12 44.6 0.1 6.8e-12 44.6 0.1 2.2 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.6 KOS20594.1 - 1.9e-05 24.9 1.7 0.0049 17.1 0.1 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20594.1 - 0.00089 19.2 6.5 0.57 10.4 0.2 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20594.1 - 0.0032 18.1 5.2 0.12 13.1 0.2 4.1 3 3 1 4 4 4 1 Tetratricopeptide repeat V-SNARE PF05008.15 KOS20594.1 - 0.37 11.2 7.1 0.41 11.1 0.1 3.3 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus HAUS-augmin3 PF14932.6 KOS20594.1 - 1.3 8.6 9.0 0.059 12.9 2.9 1.8 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 TPR_14 PF13428.6 KOS20594.1 - 1.5 9.9 3.9 4.4 8.4 0.1 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat DHquinase_I PF01487.15 KOS20595.1 - 3.6e-28 99.4 0.0 4.3e-28 99.1 0.0 1.1 1 0 0 1 1 1 1 Type I 3-dehydroquinase MFS_1 PF07690.16 KOS20597.1 - 4.2e-07 29.2 18.6 4.2e-07 29.2 18.6 4.8 3 2 1 4 4 4 3 Major Facilitator Superfamily ESSS PF10183.9 KOS20597.1 - 0.51 10.6 4.2 1.6 8.9 0.0 3.3 4 0 0 4 4 4 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Fungal_trans PF04082.18 KOS20598.1 - 1e-27 96.8 0.0 4.8e-16 58.6 0.0 2.3 2 0 0 2 2 2 2 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS20598.1 - 4.4e-10 39.5 9.7 9.5e-10 38.4 9.7 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DIOX_N PF14226.6 KOS20599.1 - 3.3e-30 105.2 0.0 4.7e-30 104.8 0.0 1.2 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOS20599.1 - 6.9e-05 23.3 0.1 0.00012 22.5 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Cwf_Cwc_15 PF04889.12 KOS20599.1 - 1.9 8.2 5.3 0.59 9.8 2.1 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Myc_N PF01056.18 KOS20600.1 - 0.021 14.8 0.5 0.031 14.2 0.5 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Paf1 PF03985.13 KOS20600.1 - 0.045 12.7 7.7 0.065 12.2 7.7 1.1 1 0 0 1 1 1 0 Paf1 Fungal_trans_2 PF11951.8 KOS20600.1 - 0.27 10.0 0.0 0.27 10.0 0.0 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain FAM176 PF14851.6 KOS20600.1 - 0.52 10.0 5.0 0.92 9.2 5.0 1.3 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 KOS20600.1 - 0.77 9.5 4.1 1.3 8.7 4.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 KOS20600.1 - 2.3 8.7 7.2 4.2 7.8 7.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4834 PF16118.5 KOS20600.1 - 3.3 8.7 8.2 7.2 7.6 8.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 KOS20601.1 - 0.24 11.0 9.9 6.7 6.3 7.1 2.4 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein GEN1_C PF18380.1 KOS20601.1 - 0.73 10.7 9.2 2.2 9.2 1.6 3.5 3 0 0 3 3 3 0 Holliday junction resolvase Gen1 C-terminal domain V-ATPase_H_N PF03224.14 KOS20603.1 - 2.5e-71 240.6 0.0 3.4e-71 240.1 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 KOS20603.1 - 9.7e-36 122.4 0.3 4.1e-35 120.4 0.0 2.3 3 0 0 3 3 3 1 V-ATPase subunit H HEAT_2 PF13646.6 KOS20603.1 - 0.034 14.5 0.1 0.3 11.5 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats GCV_T PF01571.21 KOS20604.1 - 3.8e-78 262.4 0.0 5.3e-78 261.9 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 KOS20604.1 - 1.9e-21 75.8 1.6 4.7e-21 74.5 1.6 1.7 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain Vps26 PF03643.15 KOS20605.1 - 1.2e-124 414.7 1.4 2.8e-103 344.7 0.6 2.0 2 0 0 2 2 2 2 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 KOS20605.1 - 0.0002 21.4 0.3 0.5 10.4 0.0 3.5 2 1 2 4 4 4 2 Arrestin (or S-antigen), N-terminal domain IL17R_D_N PF16742.5 KOS20605.1 - 0.088 12.9 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D CAP_N PF01213.19 KOS20605.1 - 2.8 7.3 5.4 4.6 6.6 5.4 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Ribosomal_L6 PF00347.23 KOS20606.1 - 2.7e-24 85.6 6.8 7.5e-14 52.2 2.8 2.2 2 0 0 2 2 2 2 Ribosomal protein L6 Nup160 PF11715.8 KOS20607.1 - 4.7e-137 457.9 2.7 6.7e-137 457.4 2.7 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 TPR_8 PF13181.6 KOS20607.1 - 0.13 12.6 0.1 0.48 10.8 0.1 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 KOS20607.1 - 0.15 12.3 0.0 0.5 10.6 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat RRM_1 PF00076.22 KOS20608.1 - 2e-17 62.7 0.0 2.9e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS20608.1 - 0.0016 18.5 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif Nup35_RRM_2 PF14605.6 KOS20608.1 - 0.018 15.0 0.0 0.028 14.4 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 KOS20608.1 - 0.03 14.2 0.0 0.065 13.1 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 KOS20608.1 - 0.086 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Limkain b1 SET_assoc PF11767.8 KOS20608.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated RRM_5 PF13893.6 KOS20608.1 - 0.17 11.5 0.0 0.24 11.0 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 KOS20608.1 - 0.2 11.6 0.0 0.26 11.3 0.0 1.3 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif SRA1 PF07304.11 KOS20609.1 - 3.8e-11 43.0 0.0 3.8e-11 43.0 0.0 3.3 3 1 0 3 3 3 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 KOS20609.1 - 3.6e-10 40.0 0.1 3.1e-09 36.9 0.1 2.3 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 WD40 PF00400.32 KOS20609.1 - 8.7e-06 26.4 0.6 0.043 14.7 0.0 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat BBS2_N PF14781.6 KOS20609.1 - 0.063 13.2 0.0 3.1 7.7 0.0 2.7 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal Prp18 PF02840.15 KOS20609.1 - 0.11 12.5 3.1 0.11 12.6 0.3 2.3 2 1 0 2 2 2 0 Prp18 domain HLH PF00010.26 KOS20610.1 - 2e-07 30.8 0.4 4.6e-07 29.7 0.4 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain TIP49 PF06068.13 KOS20611.1 - 1.2e-153 511.4 0.8 1.6e-153 511.1 0.8 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 KOS20611.1 - 3.1e-22 78.5 0.2 1.2e-21 76.6 0.1 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain RuvB_N PF05496.12 KOS20611.1 - 1.8e-09 37.6 0.6 1.7e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 KOS20611.1 - 3.3e-08 34.0 0.8 6.3e-05 23.4 0.1 3.4 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) DnaB_C PF03796.15 KOS20611.1 - 2.1e-06 27.3 1.2 3.6e-06 26.5 1.2 1.3 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 KOS20611.1 - 9.4e-06 26.1 0.1 2.3e-05 24.8 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 KOS20611.1 - 0.005 16.2 0.7 0.12 11.7 0.3 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 KOS20611.1 - 0.0053 17.1 0.9 0.17 12.2 0.9 2.4 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS20611.1 - 0.013 15.8 0.0 1.1 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 KOS20611.1 - 0.021 14.8 0.3 8.8 6.3 0.0 3.4 3 1 0 4 4 4 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 KOS20611.1 - 0.023 14.4 0.1 8.4 6.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 KOS20611.1 - 0.031 13.8 0.1 0.065 12.8 0.1 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOS20611.1 - 0.036 13.9 1.2 0.6 9.8 1.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOS20611.1 - 0.081 13.1 0.1 0.32 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain Phage_tube PF04985.14 KOS20611.1 - 0.089 12.5 1.0 1.1 8.9 0.5 2.5 2 0 0 2 2 2 0 Phage tail tube protein FII Hydin_ADK PF17213.3 KOS20611.1 - 0.09 13.1 0.8 0.18 12.1 0.2 1.6 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain Parvo_NS1 PF01057.17 KOS20611.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 GET2 PF08690.10 KOS20612.1 - 9.2e-50 170.1 0.0 1.1e-49 169.8 0.0 1.0 1 0 0 1 1 1 1 GET complex subunit GET2 TMEM135_C_rich PF15982.5 KOS20613.1 - 0.0053 17.4 0.7 0.026 15.1 0.2 2.4 2 1 0 2 2 2 1 N-terminal cysteine-rich region of Transmembrane protein 135 AMP-binding PF00501.28 KOS20614.1 - 1.6e-73 247.7 0.1 1.6e-73 247.7 0.1 1.6 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS20614.1 - 0.0025 18.7 0.0 0.0068 17.4 0.0 1.8 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF2721 PF11026.8 KOS20614.1 - 0.011 15.6 0.6 0.14 12.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF2781 PF10914.8 KOS20615.1 - 9.1e-22 78.1 12.7 1e-21 77.9 12.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Pyridoxal_deC PF00282.19 KOS20616.1 - 1.5e-15 56.8 0.0 1e-14 54.1 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 KOS20616.1 - 0.023 14.0 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase RGS PF00615.19 KOS20617.1 - 0.00035 20.8 0.0 0.00067 19.9 0.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain CN_hydrolase PF00795.22 KOS20618.1 - 1e-36 126.6 0.0 1.7e-36 125.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 KOS20618.1 - 2e-16 59.8 0.0 1.2e-15 57.3 0.0 2.1 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 KOS20618.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase MFS_1 PF07690.16 KOS20619.1 - 5.1e-09 35.5 3.8 6.5e-09 35.2 3.8 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily MIP PF00230.20 KOS20620.1 - 1e-20 74.5 13.7 7.5e-20 71.6 13.7 1.9 1 1 0 1 1 1 1 Major intrinsic protein ATG22 PF11700.8 KOS20621.1 - 1.2e-102 344.1 18.0 3.7e-59 200.6 9.1 2.0 1 1 1 2 2 2 2 Vacuole effluxer Atg22 like His_Phos_2 PF00328.22 KOS20622.1 - 1.9e-34 119.6 0.0 2.4e-34 119.4 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Peptidase_S8 PF00082.22 KOS20623.1 - 3.5e-32 111.9 4.1 4.3e-32 111.6 3.3 1.2 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOS20623.1 - 3.7e-17 62.8 0.0 5.7e-17 62.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I9 ETC_C1_NDUFA4 PF04800.12 KOS20625.1 - 2.3e-36 123.9 1.5 3.5e-36 123.3 1.5 1.3 1 0 0 1 1 1 1 ETC complex I subunit conserved region CLTH PF10607.9 KOS20626.1 - 1.8e-31 109.1 0.2 2.7e-31 108.4 0.1 1.3 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 KOS20626.1 - 2.9e-09 36.6 0.0 7.7e-09 35.2 0.0 1.8 1 0 0 1 1 1 1 LisH Plasmodium_Vir PF05795.11 KOS20627.1 - 0.25 10.7 2.0 0.36 10.2 2.0 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein F1F0-ATPsyn_F PF10791.9 KOS20628.1 - 4.2e-41 139.3 0.3 4.7e-41 139.2 0.3 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi RNase_T PF00929.24 KOS20629.1 - 6.5e-16 59.3 0.0 1.2e-15 58.4 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DNA_pol_A_exo1 PF01612.20 KOS20629.1 - 0.00027 20.7 0.0 0.00059 19.6 0.0 1.4 1 1 0 1 1 1 1 3'-5' exonuclease SOG2 PF10428.9 KOS20629.1 - 1.1 8.3 5.2 1.5 7.9 5.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MCM PF00493.23 KOS20630.1 - 4.9e-103 343.0 0.5 8.4e-103 342.3 0.2 1.6 1 1 1 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 KOS20630.1 - 1.6e-38 131.4 0.3 3.1e-38 130.5 0.3 1.4 1 0 0 1 1 1 1 MCM OB domain MCM6_C PF18263.1 KOS20630.1 - 2.2e-30 105.1 0.0 5e-30 103.9 0.0 1.6 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain MCM_lid PF17855.1 KOS20630.1 - 4.4e-25 87.9 0.5 2.2e-24 85.7 0.3 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 KOS20630.1 - 1.3e-22 80.3 0.1 4.2e-22 78.7 0.1 2.0 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOS20630.1 - 3.6e-07 29.8 0.0 9.7e-07 28.4 0.0 1.7 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOS20630.1 - 0.00087 19.2 0.2 0.0033 17.3 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS20630.1 - 0.0013 18.4 0.0 0.003 17.3 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 KOS20630.1 - 0.026 14.5 0.0 0.25 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) CCDC53 PF10152.9 KOS20630.1 - 0.04 14.3 0.2 0.14 12.6 0.2 1.9 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Churchill PF06573.11 KOS20630.1 - 0.04 14.3 0.0 0.69 10.3 0.0 2.4 2 0 0 2 2 2 0 Churchill protein Glyco_hydro_125 PF06824.11 KOS20631.1 - 5.3e-180 598.7 0.0 6.1e-180 598.5 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) MOZ_SAS PF01853.18 KOS20632.1 - 6.6e-81 270.3 0.2 9.2e-81 269.8 0.2 1.2 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 KOS20632.1 - 1.6e-21 75.6 0.9 3e-21 74.8 0.9 1.5 1 0 0 1 1 1 1 MYST family zinc finger domain Tudor-knot PF11717.8 KOS20632.1 - 3.1e-17 62.2 0.1 1e-16 60.6 0.0 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Acetyltransf_7 PF13508.7 KOS20632.1 - 0.00022 21.6 0.0 0.00042 20.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS20632.1 - 0.017 15.4 0.0 0.038 14.2 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DDRGK PF09756.9 KOS20632.1 - 0.24 11.0 0.0 0.24 11.0 0.0 2.9 3 0 0 3 3 3 0 DDRGK domain Glyco_transf_90 PF05686.12 KOS20633.1 - 3.9e-13 49.1 1.4 2.3e-12 46.5 1.4 1.9 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 KOS20633.1 - 0.012 16.0 0.0 0.026 14.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF2315 PF10231.9 KOS20633.1 - 1 9.5 5.4 1.9 8.6 0.1 3.1 3 1 1 4 4 4 0 Apoptogenic protein 1 PRK PF00485.18 KOS20634.1 - 4.5e-42 144.0 0.0 4.4e-41 140.8 0.0 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 KOS20634.1 - 5.5e-39 133.8 0.0 8.2e-39 133.2 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 KOS20634.1 - 2.9e-06 27.9 0.0 9.6e-06 26.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain CPT PF07931.12 KOS20634.1 - 0.0012 18.7 0.0 0.0026 17.6 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein Cytidylate_kin PF02224.18 KOS20634.1 - 0.0016 18.2 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase AAA_33 PF13671.6 KOS20634.1 - 0.0019 18.4 0.1 0.011 16.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOS20634.1 - 0.0036 17.6 0.0 0.0076 16.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOS20634.1 - 0.0044 17.5 0.3 0.11 12.9 0.0 2.8 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 KOS20634.1 - 0.0058 15.8 0.2 0.02 14.1 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_29 PF13555.6 KOS20634.1 - 0.0063 16.2 0.1 0.043 13.6 0.1 2.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_22 PF13401.6 KOS20634.1 - 0.007 16.6 0.0 0.023 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 KOS20634.1 - 0.0071 16.9 0.0 0.019 15.5 0.0 1.7 1 0 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 KOS20634.1 - 0.011 16.1 0.1 0.031 14.7 0.0 1.8 2 0 0 2 2 1 0 RNA helicase Zeta_toxin PF06414.12 KOS20634.1 - 0.017 14.4 0.0 0.056 12.7 0.0 1.8 2 0 0 2 2 2 0 Zeta toxin RsgA_GTPase PF03193.16 KOS20634.1 - 0.038 13.9 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 KOS20634.1 - 0.045 14.1 0.0 0.16 12.4 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 KOS20634.1 - 0.047 13.8 0.0 0.098 12.7 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase NACHT PF05729.12 KOS20634.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF87 PF01935.17 KOS20634.1 - 0.075 13.1 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain SKI PF01202.22 KOS20634.1 - 0.083 13.0 0.1 0.39 10.8 0.0 2.2 3 0 0 3 3 2 0 Shikimate kinase TsaE PF02367.17 KOS20634.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 KOS20634.1 - 0.13 11.3 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein dNK PF01712.19 KOS20634.1 - 0.13 12.1 0.0 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Deoxynucleoside kinase APS_kinase PF01583.20 KOS20634.1 - 0.16 11.9 0.0 0.42 10.5 0.0 1.7 1 0 0 1 1 1 0 Adenylylsulphate kinase Cytidylate_kin2 PF13189.6 KOS20634.1 - 0.17 12.0 0.1 0.53 10.4 0.0 1.9 2 0 0 2 2 2 0 Cytidylate kinase-like family RRM_1 PF00076.22 KOS20635.1 - 1.4e-13 50.5 0.6 2.1e-13 49.9 0.2 1.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS20635.1 - 0.0023 17.5 0.0 0.0027 17.3 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Guanylate_cyc PF00211.20 KOS20635.1 - 0.024 14.3 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain DUF4523 PF15023.6 KOS20635.1 - 0.039 13.8 0.0 0.084 12.7 0.0 1.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4523) RRM_3 PF08777.11 KOS20635.1 - 0.11 12.6 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA binding motif ATP-synt_D PF01813.17 KOS20636.1 - 5.2e-43 147.2 0.1 6.3e-43 146.9 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit D Suf PF05843.14 KOS20637.1 - 3.3e-05 24.0 5.0 0.007 16.4 0.3 3.6 1 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 KOS20637.1 - 3.8e-05 24.1 11.3 1.6 9.7 0.3 7.0 5 2 2 7 7 7 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS20637.1 - 0.00012 22.3 3.0 11 6.4 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_15 PF13429.6 KOS20637.1 - 0.00075 18.8 0.5 0.0017 17.6 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 KOS20637.1 - 0.003 17.5 0.3 0.057 13.4 0.1 2.8 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 Pol_alpha_B_N PF08418.10 KOS20637.1 - 0.095 12.6 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal TPR_8 PF13181.6 KOS20637.1 - 0.11 12.8 7.4 44 4.6 0.0 5.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOS20637.1 - 0.11 13.0 2.0 8.1 7.0 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOS20637.1 - 1.4 8.9 9.6 41 4.2 0.3 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat PolyA_pol PF01743.20 KOS20638.1 - 6e-25 88.1 0.7 1.9e-24 86.5 0.1 2.2 2 1 0 2 2 2 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 KOS20638.1 - 0.045 13.5 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 Probable RNA and SrmB- binding site of polymerase A DUF3666 PF12408.8 KOS20638.1 - 0.15 11.3 0.0 0.39 10.0 0.0 1.6 1 0 0 1 1 1 0 Ribose-5-phosphate isomerase Anp1 PF03452.14 KOS20639.1 - 1.2e-113 378.9 0.3 2.2e-113 378.1 0.0 1.5 2 0 0 2 2 2 1 Anp1 Rad54_N PF08658.10 KOS20639.1 - 0.044 14.0 1.3 0.077 13.2 1.3 1.3 1 0 0 1 1 1 0 Rad54 N terminal VPS38 PF17649.1 KOS20639.1 - 0.15 10.9 1.3 0.22 10.3 1.3 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Sec7 PF01369.20 KOS20640.1 - 6.8e-63 211.7 0.1 1.5e-62 210.5 0.0 1.6 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 KOS20640.1 - 1.1e-17 64.4 0.0 3.9e-17 62.6 0.0 2.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 KOS20640.1 - 0.0077 15.9 0.0 0.025 14.2 0.0 1.8 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Phage_rep_org_N PF09681.10 KOS20640.1 - 0.22 11.5 0.1 0.57 10.1 0.1 1.7 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) Syja_N PF02383.18 KOS20641.1 - 4.7e-53 180.6 0.0 7.7e-26 91.1 0.0 2.4 1 1 0 2 2 2 2 SacI homology domain Tti2 PF10521.9 KOS20642.1 - 5.3e-70 236.2 0.1 8.6e-70 235.5 0.1 1.3 1 0 0 1 1 1 1 Tti2 family V_ATPase_I PF01496.19 KOS20643.1 - 1.7e-297 988.8 0.0 1.9e-297 988.6 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SesA PF17107.5 KOS20643.1 - 0.012 15.8 4.5 0.014 15.6 0.4 2.5 3 0 0 3 3 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Exonuc_VII_L PF02601.15 KOS20643.1 - 0.012 15.2 3.1 1.5 8.3 0.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DUF1664 PF07889.12 KOS20643.1 - 0.015 15.3 4.3 1.9 8.5 1.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) CheZ PF04344.13 KOS20643.1 - 0.021 14.7 5.4 0.46 10.4 0.2 2.3 2 0 0 2 2 2 0 Chemotaxis phosphatase, CheZ DUF3552 PF12072.8 KOS20643.1 - 0.038 13.4 5.0 2.4 7.5 1.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) PspB PF06667.12 KOS20643.1 - 0.11 12.6 1.1 0.42 10.7 0.2 2.5 2 0 0 2 2 2 0 Phage shock protein B Nup54 PF13874.6 KOS20643.1 - 0.12 12.5 3.6 7.3 6.7 0.1 2.4 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 CdvA PF18822.1 KOS20643.1 - 0.15 11.9 7.9 4.6 7.1 1.0 3.1 2 1 1 3 3 3 0 CdvA-like coiled-coil domain 7TMR-HDED PF07697.11 KOS20643.1 - 0.2 11.8 5.2 0.65 10.1 0.8 2.2 2 0 0 2 2 2 0 7TM-HD extracellular Serine_rich PF08824.10 KOS20643.1 - 0.22 11.5 2.8 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 Serine rich protein interaction domain Baculo_PEP_C PF04513.12 KOS20643.1 - 0.29 11.1 8.0 3.1 7.9 3.9 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin_2 PF01920.20 KOS20643.1 - 0.3 11.1 9.3 2.4 8.1 0.2 3.1 3 0 0 3 3 3 0 Prefoldin subunit FapA PF03961.13 KOS20643.1 - 0.38 9.3 3.6 1.6 7.2 0.2 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A DUF5320 PF17253.2 KOS20643.1 - 0.67 11.1 4.4 11 7.1 0.7 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Fmp27_WPPW PF10359.9 KOS20643.1 - 0.83 8.4 4.3 5.8 5.6 0.3 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DHR10 PF18595.1 KOS20643.1 - 1.1 9.3 13.7 4.2 7.5 0.9 2.7 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain FAM76 PF16046.5 KOS20643.1 - 1.2 8.4 3.0 5.5 6.3 0.1 2.1 2 0 0 2 2 2 0 FAM76 protein Spc7 PF08317.11 KOS20643.1 - 1.5 7.6 11.1 3.7 6.3 1.3 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein UPF0449 PF15136.6 KOS20643.1 - 1.9 9.0 8.4 0.7 10.4 0.6 2.8 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 NPV_P10 PF05531.12 KOS20643.1 - 1.9 9.0 4.6 5.3 7.6 2.3 2.7 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein LXG PF04740.12 KOS20643.1 - 2.3 7.9 7.4 1.7 8.3 1.9 2.3 2 0 0 2 2 2 0 LXG domain of WXG superfamily DUF16 PF01519.16 KOS20643.1 - 2.5 8.6 6.8 2.4 8.7 0.9 2.8 2 1 0 2 2 2 0 Protein of unknown function DUF16 HMMR_N PF15905.5 KOS20643.1 - 4.1 6.8 9.7 7.1 6.0 3.6 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF3450 PF11932.8 KOS20643.1 - 4.9 6.4 13.7 1.4 8.2 0.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Golgin_A5 PF09787.9 KOS20643.1 - 5.5 6.4 11.9 1.7 8.1 3.3 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 BLOC1_2 PF10046.9 KOS20643.1 - 6.9 7.0 8.6 8.8 6.7 0.3 2.9 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CLZ PF16526.5 KOS20643.1 - 7.4 7.0 11.0 6.9 7.1 0.9 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels SKA2 PF16740.5 KOS20643.1 - 7.6 6.4 10.5 9.1 6.1 1.3 2.8 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 TPR_MLP1_2 PF07926.12 KOS20643.1 - 8 6.5 12.8 14 5.7 2.1 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CPSF73-100_C PF11718.8 KOS20644.1 - 1.1e-86 289.9 0.0 1.6e-86 289.4 0.0 1.2 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 KOS20644.1 - 3.8e-30 104.4 0.0 9.1e-30 103.2 0.0 1.7 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_6 PF16661.5 KOS20644.1 - 1.7e-18 66.8 0.1 2.9e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 KOS20644.1 - 4.5e-18 66.0 0.7 1.1e-17 64.7 0.7 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 KOS20644.1 - 9.1e-12 44.7 0.0 2.5e-11 43.3 0.0 1.8 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 KOS20644.1 - 6.8e-06 25.7 0.7 1.6e-05 24.5 0.7 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOS20644.1 - 1.2e-05 25.2 0.2 4.1e-05 23.5 0.2 1.9 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TAF4 PF05236.14 KOS20645.1 - 7.6e-35 121.0 5.5 2.6e-29 102.8 4.4 2.1 2 0 0 2 2 2 2 Transcription initiation factor TFIID component TAF4 family WD40 PF00400.32 KOS20646.1 - 1.1e-52 174.9 22.6 2.7e-08 34.3 0.3 8.5 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20646.1 - 5.2e-11 42.7 0.2 0.0022 18.2 0.0 4.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20646.1 - 2.6e-05 23.1 0.1 0.066 11.9 0.0 3.4 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Prenyltransf PF01255.19 KOS20647.1 - 1e-81 273.7 0.1 1.8e-81 273.0 0.1 1.4 1 1 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Spt20 PF12090.8 KOS20647.1 - 0.034 13.8 7.7 0.054 13.1 7.4 1.5 2 0 0 2 2 2 0 Spt20 family Roughex PF06020.11 KOS20647.1 - 0.3 10.1 11.7 0.48 9.5 11.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein WRNPLPNID PF15017.6 KOS20647.1 - 0.49 11.3 12.5 1.1 10.2 12.5 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box PTPRCAP PF15713.5 KOS20647.1 - 1 9.6 12.2 1.1 9.6 10.8 1.7 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 KOS20647.1 - 1.4 7.6 4.7 1.8 7.3 4.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 KOS20647.1 - 1.8 6.8 7.4 2.4 6.3 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 KOS20647.1 - 3.1 7.5 12.4 5.2 6.8 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Hid1 PF12722.7 KOS20647.1 - 3.3 5.7 6.8 4.1 5.4 6.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Paf1 PF03985.13 KOS20647.1 - 3.5 6.5 15.4 6.1 5.7 15.4 1.3 1 0 0 1 1 1 0 Paf1 DUF3292 PF11696.8 KOS20647.1 - 8.5 4.6 8.7 12 4.1 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3464 PF11947.8 KOS20647.1 - 9.8 5.9 6.3 16 5.2 6.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 ING PF12998.7 KOS20648.1 - 7.8e-07 29.6 0.3 0.0045 17.5 0.0 2.9 2 0 0 2 2 2 2 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KOS20648.1 - 5e-06 26.3 8.3 8.6e-06 25.5 8.3 1.4 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 KOS20648.1 - 0.18 12.1 0.9 0.47 10.8 0.9 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain Ribosomal_L24e PF01246.20 KOS20649.1 - 6.2e-32 109.6 5.1 1.3e-31 108.6 5.1 1.6 1 0 0 1 1 1 1 Ribosomal protein L24e DUF5078 PF16877.5 KOS20649.1 - 0.059 13.8 0.4 0.11 13.0 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5078) F-box-like PF12937.7 KOS20650.1 - 0.0082 16.0 0.0 0.023 14.6 0.0 1.9 1 0 0 1 1 1 1 F-box-like OSCP PF00213.18 KOS20651.1 - 1e-47 162.4 1.1 1.5e-47 162.0 1.1 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Glyco_hydro_63 PF03200.16 KOS20652.1 - 4.6e-09 35.6 11.0 1.4e-08 34.0 3.3 4.2 4 1 0 4 4 4 1 Glycosyl hydrolase family 63 C-terminal domain Hep_59 PF07052.11 KOS20652.1 - 0.59 10.9 3.2 1.3 9.9 3.2 1.5 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 Ribosomal_60s PF00428.19 KOS20654.1 - 0.021 15.4 6.3 0.021 15.4 6.3 1.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Aminotran_1_2 PF00155.21 KOS20655.1 - 4.5e-19 68.8 0.0 6.8e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Snf7 PF03357.21 KOS20656.1 - 6.4e-21 74.7 16.0 9.7e-21 74.1 16.0 1.3 1 0 0 1 1 1 1 Snf7 CDT1_C PF16679.5 KOS20656.1 - 0.006 17.0 4.6 0.012 16.0 0.0 2.8 1 1 1 2 2 2 1 DNA replication factor Cdt1 C-terminal domain LPD39 PF18858.1 KOS20656.1 - 0.019 15.1 6.5 0.033 14.3 6.5 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 39 SPOB_a PF14689.6 KOS20656.1 - 0.078 12.7 0.4 3.9 7.3 0.0 2.7 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain DnaI_N PF07319.11 KOS20656.1 - 0.2 12.3 3.4 12 6.6 0.1 2.7 2 0 0 2 2 2 0 Primosomal protein DnaI N-terminus CorA PF01544.18 KOS20656.1 - 0.42 9.9 12.1 1.3 8.3 2.3 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Peptidase_M32 PF02074.15 KOS20656.1 - 4.2 6.0 9.1 1.2 7.9 5.8 1.6 1 1 1 2 2 2 0 Carboxypeptidase Taq (M32) metallopeptidase TRAPPC-Trs85 PF12739.7 KOS20657.1 - 2.4e-116 389.1 0.1 3.4e-116 388.6 0.1 1.2 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Bud13 PF09736.9 KOS20658.1 - 6.4e-52 175.8 11.2 6.4e-52 175.8 11.2 2.3 2 1 0 3 3 3 1 Pre-mRNA-splicing factor of RES complex Cytadhesin_P30 PF07271.11 KOS20658.1 - 0.054 13.1 0.1 0.1 12.1 0.1 1.4 1 0 0 1 1 1 0 Cytadhesin P30/P32 CDI PF02234.19 KOS20659.1 - 0.17 12.1 4.1 0.33 11.2 0.3 3.0 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor TFIIF_alpha PF05793.12 KOS20659.1 - 0.72 8.4 52.7 4.7 5.7 52.4 2.8 1 1 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PAP_assoc PF03828.19 KOS20660.1 - 1.1e-17 63.9 0.1 1.2e-11 44.7 0.0 2.5 2 0 0 2 2 2 2 Cid1 family poly A polymerase XPG_I_2 PF12813.7 KOS20661.1 - 1e-34 120.1 0.0 1.6e-34 119.5 0.0 1.2 1 0 0 1 1 1 1 XPG domain containing XPG_I PF00867.18 KOS20661.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 XPG I-region Pribosyl_synth PF14572.6 KOS20662.1 - 5.5e-37 127.6 0.2 1.5e-30 106.6 0.1 2.6 2 1 0 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KOS20662.1 - 1.2e-35 121.9 0.1 7.2e-34 116.2 0.0 2.4 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KOS20662.1 - 1.9e-08 34.0 0.0 6.7e-05 22.5 0.0 2.5 2 0 0 2 2 2 2 Phosphoribosyl transferase domain Nop53 PF07767.11 KOS20663.1 - 1.6e-109 366.9 22.5 1.9e-109 366.7 22.5 1.1 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) Pyr_redox_2 PF07992.14 KOS20664.1 - 2.8e-43 148.2 0.0 4e-43 147.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS20664.1 - 7.2e-15 55.3 0.0 9.4e-11 42.1 0.0 2.9 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase EF-hand_1 PF00036.32 KOS20664.1 - 7.2e-07 28.3 0.3 1.5e-06 27.3 0.3 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 KOS20664.1 - 2.1e-05 24.1 0.5 6.3e-05 22.6 0.5 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 KOS20664.1 - 0.00031 21.1 0.1 0.0008 19.8 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOS20664.1 - 0.00041 19.7 1.1 0.0009 18.6 1.1 1.6 1 0 0 1 1 1 1 EF hand Pyr_redox_3 PF13738.6 KOS20664.1 - 0.0024 17.2 0.0 0.15 11.3 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase bVLRF1 PF18826.1 KOS20664.1 - 0.03 14.2 0.0 0.064 13.1 0.0 1.5 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor Rib_5-P_isom_A PF06026.14 KOS20665.1 - 9.1e-46 155.6 0.0 1.1e-44 152.1 0.0 2.0 1 1 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 KOS20665.1 - 0.0094 15.9 0.0 5.1 7.0 0.0 3.1 3 0 0 3 3 3 2 DeoR C terminal sensor domain Ras PF00071.22 KOS20666.1 - 1.5e-59 200.2 0.4 2.1e-59 199.7 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS20666.1 - 1.4e-37 128.6 0.1 2.5e-37 127.8 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS20666.1 - 8.4e-18 64.4 0.2 1.1e-17 64.1 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS20666.1 - 4e-07 29.8 0.1 2.5e-06 27.2 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOS20666.1 - 1.6e-05 24.3 0.3 2.1e-05 24.0 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOS20666.1 - 1.7e-05 24.3 0.0 2.7e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOS20666.1 - 1.8e-05 24.8 0.0 2.9e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS20666.1 - 0.00011 22.2 0.1 0.072 13.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 KOS20666.1 - 0.017 14.9 0.1 0.049 13.4 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein TIR_2 PF13676.6 KOS20666.1 - 0.039 14.6 0.0 0.073 13.7 0.0 1.4 1 0 0 1 1 1 0 TIR domain FlgH PF02107.16 KOS20666.1 - 0.041 13.5 0.7 0.058 13.0 0.7 1.2 1 0 0 1 1 1 0 Flagellar L-ring protein TPR_12 PF13424.6 KOS20667.1 - 3e-13 49.9 15.9 0.0043 17.3 0.2 9.5 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 KOS20667.1 - 6.7e-07 28.9 6.1 0.58 10.3 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat AAA_16 PF13191.6 KOS20667.1 - 1.8e-06 28.5 0.0 7.8e-06 26.4 0.0 2.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOS20667.1 - 0.00074 19.8 0.0 0.0058 16.9 0.0 2.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOS20667.1 - 0.01 15.8 0.0 0.063 13.2 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.6 KOS20667.1 - 0.074 13.3 0.0 0.38 11.0 0.0 2.3 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 KOS20668.1 - 3.5e-42 144.7 0.0 4.7e-42 144.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 HIG_1_N PF04588.13 KOS20668.1 - 1.2 9.4 4.4 2.2 8.6 3.1 1.9 2 0 0 2 2 2 0 Hypoxia induced protein conserved region Cys_Met_Meta_PP PF01053.20 KOS20669.1 - 5.9e-22 77.7 0.0 1.1e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOS20669.1 - 0.00045 19.5 0.0 0.00079 18.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Tho1_MOS11_C PF18592.1 KOS20669.1 - 0.087 12.6 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Tho1/MOS11 C-terminal domain RPE65 PF03055.15 KOS20670.1 - 1.1e-102 344.7 0.0 1.2e-102 344.5 0.0 1.0 1 0 0 1 1 1 1 Retinal pigment epithelial membrane protein SPESP1 PF15754.5 KOS20670.1 - 0.088 12.0 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 FMN_bind_2 PF04299.12 KOS20671.1 - 1.8e-57 193.7 0.0 2.1e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Putative FMN-binding domain FMO-like PF00743.19 KOS20672.1 - 5.4e-26 91.1 0.0 9.9e-18 63.8 0.0 3.2 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOS20672.1 - 1e-11 44.6 0.0 6.3e-09 35.5 0.0 3.0 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS20672.1 - 2.3e-09 36.9 0.0 4.9e-08 32.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS20672.1 - 2.7e-07 30.0 0.0 1.5e-05 24.3 0.0 2.3 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 KOS20672.1 - 3.6e-05 23.8 0.0 0.2 11.6 0.0 3.1 2 1 1 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 KOS20672.1 - 0.0035 17.0 0.0 3.1 7.3 0.0 2.7 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS20672.1 - 0.015 15.5 0.0 0.051 13.8 0.0 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 KOS20672.1 - 0.017 15.2 0.1 0.44 10.6 0.0 2.2 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NUDIX PF00293.28 KOS20673.1 - 1.1e-10 41.6 0.0 1.9e-10 40.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain DUF4743 PF15916.5 KOS20673.1 - 2.2e-10 40.5 0.0 3.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) Glyco_hydro_16 PF00722.21 KOS20674.1 - 3.5e-11 42.9 2.9 5.3e-11 42.3 2.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Methyltransf_11 PF08241.12 KOS20674.1 - 4.1e-10 40.2 0.0 8.2e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS20674.1 - 2.5e-09 37.7 0.0 6.3e-09 36.4 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS20674.1 - 4.6e-06 26.5 0.0 7.2e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS20674.1 - 0.00046 20.9 0.0 0.0009 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF374 PF04028.13 KOS20674.1 - 0.029 13.9 0.0 0.093 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF374) NMO PF03060.15 KOS20675.1 - 4.4e-29 101.9 5.1 1.1e-23 84.2 2.7 2.1 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 KOS20675.1 - 3.5e-06 26.3 1.0 0.051 12.6 0.9 2.1 2 0 0 2 2 2 2 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 KOS20675.1 - 0.00015 20.9 4.0 0.00015 20.9 4.0 1.7 2 0 0 2 2 2 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 KOS20675.1 - 0.015 14.4 2.3 0.029 13.5 2.3 1.4 1 1 0 1 1 1 0 Conserved region in glutamate synthase Cyclin_C_2 PF16899.5 KOS20676.1 - 1.2e-32 112.4 0.0 1.9e-30 105.3 0.0 2.4 2 0 0 2 2 2 2 Cyclin C-terminal domain Cyclin_N PF00134.23 KOS20676.1 - 2.4e-05 24.1 0.1 5e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain BAR PF03114.18 KOS20677.1 - 9.3e-45 153.1 10.1 1e-44 153.0 10.1 1.0 1 0 0 1 1 1 1 BAR domain BAR_2 PF10455.9 KOS20677.1 - 9.1e-08 31.6 3.4 1e-07 31.4 3.4 1.1 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking Lectin_N PF03954.14 KOS20677.1 - 0.036 13.8 0.8 0.09 12.5 0.3 1.8 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Pro_CA PF00484.19 KOS20678.1 - 1.3e-09 38.5 0.1 3.6e-09 37.1 0.1 1.7 1 1 0 1 1 1 1 Carbonic anhydrase Thioredoxin PF00085.20 KOS20679.1 - 3.5e-26 91.2 0.0 4.2e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOS20679.1 - 5.5e-09 35.8 0.0 5.9e-09 35.7 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOS20679.1 - 1.2e-08 35.3 0.1 4.7e-08 33.5 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOS20679.1 - 3.7e-05 24.0 0.0 0.00051 20.3 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOS20679.1 - 5.9e-05 22.8 0.0 7.6e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOS20679.1 - 8.2e-05 22.7 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.21 KOS20679.1 - 0.00048 20.0 0.1 0.02 14.8 0.0 2.1 1 1 1 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 KOS20679.1 - 0.0043 16.8 0.1 0.13 12.0 0.1 2.1 1 1 1 2 2 2 1 Redoxin HyaE PF07449.11 KOS20679.1 - 0.014 15.4 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE TraF PF13728.6 KOS20679.1 - 0.032 14.0 0.0 0.052 13.4 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 KOS20679.1 - 0.038 14.0 0.0 0.089 12.9 0.0 1.6 1 1 0 1 1 1 0 Thioredoxin domain Glutaredoxin PF00462.24 KOS20679.1 - 0.046 13.9 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 Glutaredoxin DIM1 PF02966.16 KOS20679.1 - 0.046 13.5 0.0 0.055 13.2 0.0 1.1 1 0 0 1 1 1 0 Mitosis protein DIM1 DSBA PF01323.20 KOS20679.1 - 0.11 12.2 0.3 4 7.2 0.1 2.2 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF953 PF06110.11 KOS20679.1 - 0.14 11.7 0.0 0.52 9.9 0.0 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) NAGLU PF05089.12 KOS20680.1 - 3.5e-128 427.3 4.6 5.3e-128 426.7 4.6 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 KOS20680.1 - 2.2e-71 240.5 0.2 3.4e-71 239.9 0.2 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU_N PF12971.7 KOS20680.1 - 5e-09 35.8 0.0 1.4e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain DUF2385 PF09539.10 KOS20680.1 - 0.14 12.7 0.0 0.38 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) Anoctamin PF04547.12 KOS20681.1 - 2e-104 349.9 7.8 2.4e-104 349.7 7.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel CcmH PF03918.14 KOS20681.1 - 0.04 13.2 0.0 0.16 11.2 0.0 2.0 1 0 0 1 1 1 0 Cytochrome C biogenesis protein GDPD_2 PF13653.6 KOS20681.1 - 0.051 14.0 2.2 0.14 12.6 0.0 3.0 3 0 0 3 3 3 0 Glycerophosphoryl diester phosphodiesterase family CN_hydrolase PF00795.22 KOS20682.1 - 3.3e-28 98.7 0.0 4.8e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CDH-cyt PF16010.5 KOS20683.1 - 7.1e-09 35.6 0.5 1.9e-08 34.2 0.5 1.6 1 1 0 1 1 1 1 Cytochrome domain of cellobiose dehydrogenase Herpes_gE PF02480.16 KOS20683.1 - 0.013 14.3 0.0 0.021 13.6 0.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E Cytochrom_B561 PF03188.16 KOS20683.1 - 0.014 15.6 8.9 0.025 14.7 8.9 1.4 1 0 0 1 1 1 0 Eukaryotic cytochrome b561 DUF4079 PF13301.6 KOS20683.1 - 0.1 12.7 10.1 0.071 13.3 7.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) DUF2427 PF10348.9 KOS20683.1 - 0.11 12.3 0.3 0.28 11.0 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) NIR_SIR PF01077.22 KOS20684.1 - 1e-54 184.4 0.1 1.5e-49 167.5 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 KOS20684.1 - 1.5e-32 111.2 0.0 3.9e-16 58.6 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 KOS20684.1 - 2.5e-28 99.1 0.0 5.4e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin POR_N PF01855.19 KOS20684.1 - 3.8e-06 26.8 0.1 1.2e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Kei1 PF08552.11 KOS20685.1 - 2.6e-56 190.5 2.3 3.2e-56 190.3 2.3 1.1 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 SPC12 PF06645.13 KOS20685.1 - 0.019 15.0 3.0 0.019 15.0 3.0 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) 7TMR-DISM_7TM PF07695.11 KOS20685.1 - 0.15 11.9 11.8 0.02 14.8 7.4 1.7 2 0 0 2 2 2 0 7TM diverse intracellular signalling MARVEL PF01284.23 KOS20685.1 - 6.2 6.8 11.8 2.7 8.0 6.0 2.1 1 1 1 2 2 2 0 Membrane-associating domain Mob1_phocein PF03637.17 KOS20686.1 - 3.5e-69 232.2 0.0 4.6e-69 231.8 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family Chitin_synth_1 PF01644.17 KOS20687.1 - 1.1e-77 259.6 0.0 1.6e-77 259.0 0.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 KOS20687.1 - 2.7e-27 94.5 0.1 6.1e-27 93.4 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 KOS20687.1 - 2.3e-25 89.2 2.9 1.1e-21 77.1 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS20687.1 - 1.2e-08 35.1 0.4 1.2e-08 35.1 0.4 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 ThiF PF00899.21 KOS20688.1 - 7e-18 64.9 0.0 1.9e-17 63.5 0.0 1.7 1 1 0 1 1 1 1 ThiF family DUF1732 PF08340.11 KOS20688.1 - 0.0086 16.0 0.2 0.03 14.3 0.2 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1732) Prok-RING_4 PF14447.6 KOS20688.1 - 0.041 13.8 0.4 0.084 12.7 0.4 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CLZ PF16526.5 KOS20688.1 - 0.048 14.0 4.5 0.11 12.9 4.5 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels zf-RING_5 PF14634.6 KOS20688.1 - 0.05 13.6 0.7 0.05 13.6 0.7 1.6 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 KOS20688.1 - 0.083 13.2 0.3 0.17 12.3 0.3 1.5 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 KOS20688.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 RING-type zinc-finger DUF5082 PF16888.5 KOS20688.1 - 0.14 12.4 5.5 0.26 11.6 5.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) zinc_ribbon_10 PF10058.9 KOS20688.1 - 0.18 11.6 0.2 0.39 10.5 0.2 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein CENP-H PF05837.12 KOS20688.1 - 1.4 9.3 7.2 3.1 8.3 7.2 1.5 1 0 0 1 1 1 0 Centromere protein H (CENP-H) adh_short PF00106.25 KOS20689.1 - 5.8e-50 169.5 0.0 7.8e-50 169.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20689.1 - 4.8e-33 114.7 0.2 5.8e-33 114.4 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20689.1 - 2.7e-14 53.5 0.1 5.3e-14 52.5 0.1 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 KOS20689.1 - 0.054 12.6 0.0 0.45 9.6 0.0 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein DUF1776 PF08643.10 KOS20689.1 - 0.082 12.3 0.0 0.54 9.6 0.0 2.1 2 1 0 2 2 2 0 Fungal family of unknown function (DUF1776) RecC_C PF17946.1 KOS20689.1 - 0.13 12.0 0.0 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 RecC C-terminal domain RNA_pol_Rpb8 PF03870.15 KOS20690.1 - 4.9e-45 153.1 0.0 5.5e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 KOS20690.1 - 5.4e-05 23.2 0.3 0.038 14.0 0.0 2.1 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NB-ARC PF00931.22 KOS20690.1 - 0.088 12.0 0.0 0.11 11.6 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain DUF775 PF05603.12 KOS20691.1 - 1.5e-54 184.6 0.0 7e-54 182.4 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF775) GDA1_CD39 PF01150.17 KOS20692.1 - 3.6e-104 348.8 0.0 5e-104 348.3 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family RNase_PH PF01138.21 KOS20693.1 - 3.4e-24 85.8 0.0 5.5e-24 85.2 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 zf-C3HC4_3 PF13920.6 KOS20694.1 - 3.7e-07 29.9 15.3 5.9e-07 29.3 15.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SDA1 PF05285.12 KOS20694.1 - 0.00018 21.1 1.0 0.00027 20.5 1.0 1.2 1 0 0 1 1 1 1 SDA1 CHZ PF09649.10 KOS20694.1 - 0.13 11.8 0.3 0.29 10.6 0.3 1.6 1 0 0 1 1 1 0 Histone chaperone domain CHZ GGA_N-GAT PF18308.1 KOS20694.1 - 2.6 7.7 4.9 1.4 8.6 0.8 2.2 2 0 0 2 2 2 0 GGA N-GAT domain Prok-RING_4 PF14447.6 KOS20694.1 - 2.6 8.0 15.2 4.4 7.2 15.2 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 tRNA_int_endo PF01974.17 KOS20695.1 - 7.7e-11 41.9 0.0 1.7e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PAXNEB PF05625.11 KOS20696.1 - 3.4e-81 273.3 0.0 3.8e-81 273.1 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein hDGE_amylase PF14701.6 KOS20697.1 - 3.3e-177 590.0 0.0 4.4e-177 589.6 0.0 1.2 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 KOS20697.1 - 9.6e-120 400.0 0.0 1.6e-119 399.3 0.0 1.3 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 KOS20697.1 - 3e-85 285.9 0.0 5e-85 285.2 0.0 1.4 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 KOS20697.1 - 1.2e-29 102.3 0.1 2.4e-29 101.3 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain from the human glycogen debranching enzyme Dicty_REP PF05086.12 KOS20698.1 - 0.94 7.4 7.1 0.98 7.3 7.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hamartin PF04388.12 KOS20698.1 - 4 6.0 8.7 4.1 5.9 8.7 1.1 1 0 0 1 1 1 0 Hamartin protein Mucin PF01456.17 KOS20698.1 - 6.8 6.7 18.4 11 6.1 18.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Peptidase_C48 PF02902.19 KOS20699.1 - 1.6e-17 64.1 0.0 4.5e-17 62.6 0.0 1.8 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain NTP_transferase PF00483.23 KOS20700.1 - 3e-27 95.8 0.0 6.3e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyl transferase MannoseP_isomer PF01050.18 KOS20700.1 - 5.3e-05 23.2 0.1 9.3e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase DUF4200 PF13863.6 KOS20700.1 - 0.052 14.0 0.2 0.11 12.9 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) NAD_Gly3P_dh_N PF01210.23 KOS20701.1 - 3e-44 150.8 0.0 4.9e-44 150.1 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 KOS20701.1 - 6.6e-40 136.7 0.1 1.1e-39 136.0 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 KOS20701.1 - 0.066 13.8 0.0 18 6.0 0.0 2.6 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Chromo PF00385.24 KOS20702.1 - 2e-07 30.8 0.4 2.1e-05 24.4 0.1 2.9 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain MCPVI PF02993.14 KOS20702.1 - 4.8 7.0 10.7 0.023 14.5 1.7 1.6 2 0 0 2 2 2 0 Minor capsid protein VI Pam17 PF08566.10 KOS20703.1 - 2e-63 213.2 0.0 2.8e-63 212.7 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 ThiF PF00899.21 KOS20704.1 - 1.1e-58 198.5 0.0 1.5e-58 198.1 0.0 1.3 1 0 0 1 1 1 1 ThiF family Rhodanese PF00581.20 KOS20704.1 - 1.1e-10 41.9 0.0 4.4e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain Shikimate_DH PF01488.20 KOS20704.1 - 0.059 13.4 0.2 0.2 11.7 0.1 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 KOS20704.1 - 0.089 13.2 0.0 0.3 11.5 0.0 1.9 1 1 0 1 1 1 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 KOS20704.1 - 0.13 11.8 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ABC_tran_CTD PF16326.5 KOS20704.1 - 0.18 12.1 0.6 0.38 11.0 0.6 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain DUF1192 PF06698.11 KOS20704.1 - 2.6 8.2 4.9 5.8 7.1 4.9 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) SLX9 PF15341.6 KOS20705.1 - 1.4e-23 83.7 1.8 2.1e-23 83.1 1.8 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 DUF4772 PF15997.5 KOS20705.1 - 2.2 8.9 6.7 10 6.8 6.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4772) RAP1 PF07218.11 KOS20705.1 - 9.6 4.3 5.4 12 4.0 5.4 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Phosducin PF02114.16 KOS20706.1 - 2.4e-11 43.1 0.0 3.5e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 KOS20706.1 - 0.016 15.2 0.0 0.027 14.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin adh_short PF00106.25 KOS20707.1 - 5.9e-43 146.6 0.0 7.9e-43 146.2 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20707.1 - 6.8e-28 97.8 0.0 9.4e-28 97.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20707.1 - 7.6e-06 25.9 0.1 1.2e-05 25.3 0.1 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS20707.1 - 0.00055 19.5 0.0 0.00089 18.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 KOS20707.1 - 0.038 13.4 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 KOS20707.1 - 0.13 11.3 0.0 0.18 10.8 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Ferric_reduct PF01794.19 KOS20709.1 - 5.3e-18 65.3 6.7 5.3e-18 65.3 6.7 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOS20709.1 - 3.3e-14 53.3 0.0 7.2e-13 49.0 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS20709.1 - 1e-12 48.1 0.0 2.3e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_1 PF00175.21 KOS20709.1 - 0.00095 19.8 0.0 0.25 12.0 0.0 2.8 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain DUF4405 PF14358.6 KOS20709.1 - 0.22 12.1 8.5 0.14 12.7 1.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) HMGL-like PF00682.19 KOS20710.1 - 4.2e-78 262.6 0.0 5.6e-78 262.1 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 KOS20710.1 - 1.6e-24 86.3 0.0 3.1e-24 85.4 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain PFK PF00365.20 KOS20712.1 - 8.3e-189 625.8 0.1 2.7e-104 348.5 0.3 2.1 2 0 0 2 2 2 2 Phosphofructokinase TgMIC1 PF11476.8 KOS20712.1 - 0.67 9.7 2.5 1.9 8.3 0.1 2.6 3 0 0 3 3 3 0 Toxoplasma gondii micronemal protein 1 TgMIC1 UVR PF02151.19 KOS20712.1 - 3.6 7.4 5.9 0.63 9.9 1.4 2.1 2 0 0 2 2 2 0 UvrB/uvrC motif Med17 PF10156.9 KOS20713.1 - 1.1e-88 298.0 0.0 1.4e-88 297.7 0.0 1.0 1 0 0 1 1 1 1 Subunit 17 of Mediator complex RNase_PH PF01138.21 KOS20714.1 - 5.5e-16 59.3 0.0 1.4e-15 57.9 0.0 1.7 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOS20714.1 - 0.0078 16.2 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 ADH_zinc_N PF00107.26 KOS20714.1 - 0.16 11.9 0.0 0.34 10.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase GDI PF00996.18 KOS20715.1 - 1.2e-20 73.5 0.0 1.2e-09 37.3 0.0 2.1 2 0 0 2 2 2 2 GDP dissociation inhibitor Rad21_Rec8_N PF04825.13 KOS20716.1 - 3.9e-32 110.7 0.0 6.3e-32 110.0 0.0 1.3 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 KOS20716.1 - 1.6e-06 27.3 0.0 3.8e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein HEAT PF02985.22 KOS20717.1 - 1e-12 47.1 12.0 0.015 15.5 0.0 10.1 11 0 0 11 11 10 2 HEAT repeat HEAT_EZ PF13513.6 KOS20717.1 - 9.1e-11 42.0 11.4 1.2e-08 35.2 0.0 7.5 8 2 2 10 10 10 1 HEAT-like repeat IBN_N PF03810.19 KOS20717.1 - 1.8e-10 40.5 4.3 2.5e-08 33.7 0.5 4.1 3 0 0 3 3 3 1 Importin-beta N-terminal domain HEAT_2 PF13646.6 KOS20717.1 - 4.3e-09 36.6 12.1 0.0026 18.1 0.1 6.8 4 2 3 7 7 7 3 HEAT repeats CLASP_N PF12348.8 KOS20717.1 - 0.00092 18.8 2.3 2 7.9 0.1 5.0 5 1 2 7 7 7 1 CLASP N terminal Tti2 PF10521.9 KOS20717.1 - 0.0031 17.1 0.1 3 7.3 0.0 4.1 3 1 1 4 4 4 1 Tti2 family DUF3385 PF11865.8 KOS20717.1 - 0.008 16.1 3.9 4.9 7.0 0.0 4.9 4 1 3 7 7 7 1 Domain of unknown function (DUF3385) RIX1 PF08167.12 KOS20717.1 - 0.015 15.1 0.6 6.9 6.4 0.0 4.3 3 1 2 5 5 5 0 rRNA processing/ribosome biogenesis NUC173 PF08161.12 KOS20717.1 - 0.048 13.3 0.9 21 4.7 0.0 4.3 3 2 0 3 3 3 0 NUC173 domain Dopey_N PF04118.14 KOS20717.1 - 0.074 12.2 0.4 0.35 10.0 0.3 2.2 1 1 0 1 1 1 0 Dopey, N-terminal HEAT_PBS PF03130.16 KOS20717.1 - 0.13 13.0 0.1 87 4.2 0.0 4.8 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat Arm PF00514.23 KOS20717.1 - 0.22 11.7 5.5 15 5.8 0.0 5.2 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat OB_NTP_bind PF07717.16 KOS20718.1 - 2.8e-05 24.4 0.0 4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Methyltransf_2 PF00891.18 KOS20719.1 - 1e-20 74.0 0.0 1.3e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 KOS20719.1 - 0.0013 18.6 0.1 0.0069 16.4 0.0 2.2 1 1 1 2 2 2 1 Dimerisation domain Dimerisation PF08100.11 KOS20719.1 - 0.0095 15.9 0.0 0.029 14.4 0.0 1.9 1 0 0 1 1 1 1 Dimerisation domain Ribosomal_L22 PF00237.19 KOS20720.1 - 6.2e-23 81.0 0.0 1.1e-22 80.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Spore_coat_CotO PF14153.6 KOS20720.1 - 0.26 11.2 5.2 0.52 10.2 5.2 1.4 1 0 0 1 1 1 0 Spore coat protein CotO adh_short_C2 PF13561.6 KOS20722.1 - 3e-50 171.0 0.2 4.1e-50 170.5 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS20722.1 - 3.5e-39 134.3 0.2 4.5e-39 133.9 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS20722.1 - 1.2e-05 25.3 0.7 1.9e-05 24.6 0.7 1.3 1 0 0 1 1 1 1 KR domain CPL PF08144.11 KOS20724.1 - 5.5e-45 153.2 0.0 4.1e-43 147.1 0.0 3.5 4 0 0 4 4 4 1 CPL (NUC119) domain CTI PF06934.11 KOS20724.1 - 0.019 13.5 0.0 0.029 12.9 0.0 1.3 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) TraH_2 PF06871.11 KOS20724.1 - 9 5.9 7.5 0.73 9.4 0.2 2.6 3 0 0 3 3 3 0 TraH_2 RNA_pol_Rpb4 PF03874.16 KOS20725.1 - 4.3e-26 91.6 4.8 5.5e-26 91.3 4.8 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Mu-like_Pro PF10123.9 KOS20725.1 - 0.37 10.3 3.1 0.39 10.2 3.1 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein Sybindin PF04099.12 KOS20726.1 - 3.7e-53 179.3 0.0 4.2e-53 179.1 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 KOS20726.1 - 1.1e-07 32.0 0.0 1.6e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region SNO PF01174.19 KOS20727.1 - 1.2e-53 181.8 0.0 3e-51 173.9 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 KOS20727.1 - 5.7e-10 39.1 0.0 2.3e-08 33.9 0.0 2.1 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 KOS20727.1 - 0.00096 19.0 0.2 0.0019 18.0 0.0 1.6 2 0 0 2 2 2 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 KOS20727.1 - 0.0016 18.2 0.0 0.0024 17.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 GATase PF00117.28 KOS20727.1 - 0.0038 17.0 0.0 0.046 13.5 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SOR_SNZ PF01680.17 KOS20728.1 - 9e-101 335.9 7.9 1.3e-100 335.3 7.9 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 KOS20728.1 - 1.7e-09 37.4 5.7 6.8e-08 32.1 0.2 2.4 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG Dus PF01207.17 KOS20728.1 - 0.00043 19.5 0.8 0.36 9.9 0.0 2.5 3 0 0 3 3 3 2 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 KOS20728.1 - 0.0057 16.1 0.4 0.064 12.7 0.1 2.3 2 0 0 2 2 2 1 Histidine biosynthesis protein NanE PF04131.14 KOS20728.1 - 0.0066 15.6 1.9 0.13 11.5 0.0 3.1 2 2 0 3 3 3 1 Putative N-acetylmannosamine-6-phosphate epimerase IGPS PF00218.21 KOS20728.1 - 0.0069 15.6 0.1 0.061 12.5 0.0 2.3 2 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase TetR_C_27 PF17935.1 KOS20728.1 - 0.0073 16.3 0.0 0.022 14.8 0.0 1.8 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TMP-TENI PF02581.17 KOS20728.1 - 0.035 13.4 1.1 0.5 9.7 0.1 2.7 2 1 0 2 2 2 0 Thiamine monophosphate synthase OMPdecase PF00215.24 KOS20728.1 - 0.045 13.3 0.2 0.11 12.0 0.2 1.4 1 1 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family NMO PF03060.15 KOS20728.1 - 2.4 7.4 11.2 0.61 9.4 2.9 2.3 2 0 0 2 2 2 0 Nitronate monooxygenase Glyco_hyd_65N_2 PF14498.6 KOS20729.1 - 2.2e-52 178.3 0.0 3.2e-52 177.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 KOS20729.1 - 0.11 11.4 0.1 0.19 10.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain PI3_PI4_kinase PF00454.27 KOS20730.1 - 4.8e-48 164.2 0.0 7.6e-48 163.5 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 KOS20730.1 - 3.2e-33 115.4 3.6 4.6e-33 114.9 3.6 1.2 1 0 0 1 1 1 1 FAT domain FATC PF02260.20 KOS20730.1 - 2.2e-18 65.8 0.0 4.3e-18 64.8 0.0 1.5 1 0 0 1 1 1 1 FATC domain TPR_19 PF14559.6 KOS20730.1 - 0.0063 17.0 0.3 0.0063 17.0 0.3 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS20730.1 - 0.36 11.8 5.6 32 5.7 0.0 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat GGACT PF06094.12 KOS20731.1 - 3.9e-10 40.4 0.0 5.1e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 KOS20731.1 - 9.6e-07 29.1 0.2 1.3e-05 25.5 0.1 2.7 2 1 0 2 2 2 1 AIG2-like family Putative_PNPOx PF01243.20 KOS20732.1 - 6.4e-12 45.5 0.0 1.8e-11 44.1 0.1 1.8 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 KOS20732.1 - 0.16 12.0 0.0 0.49 10.4 0.0 1.7 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase Menin PF05053.13 KOS20732.1 - 0.23 9.8 4.5 0.29 9.4 4.5 1.1 1 0 0 1 1 1 0 Menin TMEM174 PF15029.6 KOS20732.1 - 0.53 10.0 4.5 0.16 11.7 1.6 1.5 2 0 0 2 2 2 0 Transmembrane protein 174 DUF4175 PF13779.6 KOS20732.1 - 0.68 7.8 5.3 2.7 5.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) CDC45 PF02724.14 KOS20732.1 - 1.4 7.1 4.3 1.9 6.7 4.3 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOS20732.1 - 4.7 6.5 9.8 7.3 5.8 9.8 1.2 1 0 0 1 1 1 0 NOA36 protein Mem_trans PF03547.18 KOS20733.1 - 6.5e-53 179.5 0.0 1.1e-52 178.8 0.0 1.3 1 1 0 1 1 1 1 Membrane transport protein Amidoligase_2 PF12224.8 KOS20734.1 - 3.4e-11 43.3 0.0 5.5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 Putative amidoligase enzyme CPSase_L_D2 PF02786.17 KOS20735.1 - 1.9e-72 243.2 0.1 4.2e-72 242.1 0.0 1.6 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOS20735.1 - 9.6e-35 119.5 0.1 2.6e-34 118.1 0.1 1.8 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOS20735.1 - 1.1e-34 118.7 0.0 4e-34 116.9 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOS20735.1 - 2.4e-16 59.3 0.5 5.6e-16 58.1 0.5 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 KOS20735.1 - 1e-08 34.8 0.0 0.0062 16.3 0.0 2.9 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp PF02222.22 KOS20735.1 - 3.1e-07 30.1 0.0 6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOS20735.1 - 1e-05 25.2 0.0 2.7e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus HlyD_3 PF13437.6 KOS20735.1 - 0.00051 20.7 0.1 1.2 9.9 0.0 2.9 3 0 0 3 3 2 2 HlyD family secretion protein ATP-grasp_3 PF02655.14 KOS20735.1 - 0.0021 18.1 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Serglycin PF04360.12 KOS20735.1 - 0.01 15.8 0.2 0.018 15.0 0.2 1.3 1 0 0 1 1 1 0 Serglycin HlyD_D23 PF16576.5 KOS20735.1 - 0.016 14.5 0.0 2.6 7.2 0.0 2.6 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 KOS20735.1 - 0.072 13.0 0.2 0.41 10.5 0.1 2.2 2 0 0 2 2 2 0 Glycine cleavage H-protein ATPgrasp_ST PF14397.6 KOS20735.1 - 0.16 11.2 0.0 0.59 9.3 0.0 1.8 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp LAL_C2 PF18603.1 KOS20735.1 - 0.23 11.6 0.1 0.23 11.6 0.1 3.2 4 0 0 4 4 2 0 L-amino acid ligase C-terminal domain 2 BPL_LplA_LipB PF03099.19 KOS20736.1 - 0.0021 18.0 0.0 0.024 14.6 0.0 2.1 2 0 0 2 2 2 1 Biotin/lipoate A/B protein ligase family Trypan_PARP PF05887.11 KOS20736.1 - 0.0094 15.9 2.9 0.016 15.2 2.9 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) CCDC53 PF10152.9 KOS20736.1 - 0.061 13.7 7.2 2 8.8 0.8 2.1 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Pex14_N PF04695.13 KOS20736.1 - 0.15 12.7 19.4 0.43 11.2 5.0 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SelP_N PF04592.14 KOS20736.1 - 2.6 7.4 7.4 0.19 11.1 1.7 1.8 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Glyco_hydro_18 PF00704.28 KOS20737.1 - 8.3e-18 65.2 0.1 1.2e-17 64.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Ustilago_mating PF05722.12 KOS20737.1 - 0.41 10.1 6.8 0.71 9.4 6.8 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein Pkinase PF00069.25 KOS20738.1 - 1.9e-53 181.5 0.0 1.9e-50 171.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20738.1 - 3.5e-29 101.9 0.0 5.8e-28 97.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Seadorna_VP7 PF07387.11 KOS20738.1 - 0.00017 20.8 0.1 0.00079 18.6 0.1 1.8 2 0 0 2 2 2 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 KOS20738.1 - 0.016 14.0 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KOS20738.1 - 0.023 13.7 0.0 0.033 13.1 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 KOS20738.1 - 0.068 12.5 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Kinase-like SUR7 PF06687.12 KOS20739.1 - 1.2e-25 90.4 1.3 1.6e-25 90.0 1.3 1.1 1 0 0 1 1 1 1 SUR7/PalI family Clc-like PF07062.12 KOS20739.1 - 0.05 13.1 1.1 0.076 12.5 1.1 1.2 1 0 0 1 1 1 0 Clc-like Form-deh_trans PF09163.11 KOS20739.1 - 2.6 7.9 8.8 0.77 9.6 4.0 2.5 2 0 0 2 2 2 0 Formate dehydrogenase N, transmembrane Claudin_2 PF13903.6 KOS20739.1 - 3.9 7.2 15.1 0.76 9.5 9.9 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF3602 PF12223.8 KOS20740.1 - 5.7e-14 52.5 6.3 3.7e-11 43.5 2.1 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF3602) FAM222A PF15258.6 KOS20740.1 - 0.0091 15.2 0.0 0.0093 15.1 0.0 1.1 1 0 0 1 1 1 1 Protein family of FAM222A HisG PF01634.18 KOS20741.1 - 3.6e-42 144.0 0.0 8.2e-42 142.9 0.0 1.6 1 1 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 KOS20741.1 - 1.7e-28 98.5 0.2 4.4e-28 97.2 0.2 1.7 1 0 0 1 1 1 1 HisG, C-terminal domain RE_Eco29kI PF09517.10 KOS20741.1 - 0.055 13.1 0.0 1.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Eco29kI restriction endonuclease Complex1_LYR_2 PF13233.6 KOS20742.1 - 5e-20 72.0 0.0 8.9e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR PF05347.15 KOS20742.1 - 4.2e-11 42.7 0.0 7.9e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 KOS20742.1 - 0.0022 18.6 0.0 0.0036 17.9 0.0 1.5 1 0 0 1 1 1 1 Complex1_LYR-like HA2 PF04408.23 KOS20743.1 - 1.9e-19 70.0 0.1 5e-19 68.6 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOS20743.1 - 7.3e-13 48.8 0.0 1.7e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 KOS20743.1 - 6.1e-12 45.7 0.1 3e-11 43.5 0.1 2.1 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 KOS20743.1 - 1.2e-06 28.4 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOS20743.1 - 1e-05 25.8 0.0 2.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS20743.1 - 0.00073 20.0 0.4 0.0058 17.0 0.1 2.6 2 1 0 2 2 2 1 AAA ATPase domain ATPase PF06745.13 KOS20743.1 - 0.0032 16.9 0.0 0.0074 15.7 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_29 PF13555.6 KOS20743.1 - 0.0072 16.0 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KOS20743.1 - 0.025 15.1 0.0 0.087 13.3 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 KOS20743.1 - 0.097 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 KOS20743.1 - 0.1 13.1 0.0 0.41 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain ING PF12998.7 KOS20744.1 - 1.3e-20 73.8 2.3 2.2e-20 73.1 2.3 1.3 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 KOS20744.1 - 8.6e-05 22.4 9.4 0.00015 21.6 9.4 1.4 1 0 0 1 1 1 1 PHD-finger zf-RING_2 PF13639.6 KOS20744.1 - 1.5 9.3 6.8 2.9 8.3 6.8 1.5 1 0 0 1 1 1 0 Ring finger domain Methyltransf_16 PF10294.9 KOS20745.1 - 0.0052 16.5 0.0 0.016 15.0 0.0 1.7 2 0 0 2 2 2 1 Lysine methyltransferase DUF3446 PF11928.8 KOS20745.1 - 0.018 15.3 7.3 0.17 12.2 0.2 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain Methyltransf_31 PF13847.6 KOS20745.1 - 0.1 12.4 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Rab5ip PF07019.12 KOS20746.1 - 2.7e-28 98.4 7.8 3.2e-28 98.1 7.8 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) RL11D PF11088.8 KOS20746.1 - 0.035 14.4 0.0 0.53 10.6 0.0 2.0 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 BCLP PF12304.8 KOS20746.1 - 0.048 13.2 0.6 6.3 6.3 0.0 2.2 1 1 0 2 2 2 0 Beta-casein like protein URO-D PF01208.17 KOS20747.1 - 2.2e-118 395.4 0.0 2.4e-118 395.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) V-SNARE_C PF12352.8 KOS20748.1 - 0.023 15.0 6.0 0.11 12.8 1.5 2.6 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus RRM_1 PF00076.22 KOS20750.1 - 7.2e-48 160.3 0.1 9.9e-17 60.5 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 KOS20750.1 - 1.6e-30 104.8 0.0 1.3e-26 92.3 0.0 3.6 3 0 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 KOS20750.1 - 1.1e-10 41.1 0.0 9.3e-07 28.5 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS20750.1 - 5.6e-09 35.9 0.0 0.0077 16.2 0.0 3.7 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 KOS20750.1 - 3.2e-05 24.0 0.0 0.23 11.6 0.0 4.1 4 0 0 4 4 4 1 RNA recognition motif RRM_3 PF08777.11 KOS20750.1 - 0.0091 16.0 0.2 0.46 10.6 0.0 3.2 3 0 0 3 3 3 1 RNA binding motif Lsm_interact PF05391.11 KOS20750.1 - 0.012 15.0 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 Lsm interaction motif RL PF17797.1 KOS20750.1 - 0.016 15.2 0.0 0.083 12.8 0.0 2.2 2 0 0 2 2 2 0 RL domain PHM7_cyt PF14703.6 KOS20750.1 - 0.035 14.3 5.3 14 5.9 0.1 4.5 4 1 1 5 5 5 0 Cytosolic domain of 10TM putative phosphate transporter Striatin PF08232.12 KOS20750.1 - 4.6 7.8 13.4 0.23 12.1 5.1 2.8 3 0 0 3 3 3 0 Striatin family TMEM154 PF15102.6 KOS20751.1 - 0.00054 19.9 0.5 0.0017 18.2 0.0 2.0 1 1 1 2 2 2 1 TMEM154 protein family SKG6 PF08693.10 KOS20751.1 - 0.004 16.5 2.6 0.0077 15.6 2.6 1.5 1 0 0 1 1 1 1 Transmembrane alpha-helix domain EphA2_TM PF14575.6 KOS20751.1 - 0.004 18.0 0.0 0.02 15.8 0.0 2.0 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 KOS20751.1 - 0.057 13.5 12.8 0.79 9.8 12.8 2.1 1 1 0 1 1 1 0 Podoplanin DUF5460 PF17544.2 KOS20751.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5460) Fungal_trans_2 PF11951.8 KOS20752.1 - 1.9e-25 89.5 0.1 2.3e-25 89.2 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS20752.1 - 6.3e-07 29.4 9.1 1.3e-06 28.4 9.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain zf-C2H2 PF00096.26 KOS20753.1 - 1.2e-09 38.0 10.1 0.00025 21.3 1.1 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS20753.1 - 1.2e-06 28.7 8.3 5.6e-06 26.5 0.6 3.2 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS20753.1 - 1.9e-05 25.1 9.3 0.033 15.0 1.1 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOS20753.1 - 0.0071 16.3 0.9 0.0071 16.3 0.9 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 KOS20753.1 - 0.039 14.3 5.7 0.05 14.0 1.6 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 KOS20753.1 - 0.043 14.1 4.4 0.054 13.8 0.4 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF1770 PF08589.10 KOS20753.1 - 0.2 12.7 0.2 0.2 12.7 0.2 2.3 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) Pkinase PF00069.25 KOS20755.1 - 1.6e-55 188.3 0.1 2.3e-35 122.3 0.0 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20755.1 - 8.5e-38 130.1 0.0 2.2e-37 128.8 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS20755.1 - 4.8e-05 22.8 0.0 0.0001 21.7 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Corona_S2 PF01601.16 KOS20755.1 - 0.029 12.9 0.0 0.043 12.3 0.0 1.1 1 0 0 1 1 1 0 Coronavirus S2 glycoprotein DUF3896 PF13035.6 KOS20755.1 - 0.033 14.3 0.9 0.32 11.2 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) Serglycin PF04360.12 KOS20755.1 - 0.077 12.9 5.6 0.24 11.3 5.6 1.8 1 0 0 1 1 1 0 Serglycin Spt20 PF12090.8 KOS20755.1 - 3.3 7.3 23.9 5 6.7 5.2 2.4 2 0 0 2 2 2 0 Spt20 family SUIM_assoc PF16619.5 KOS20755.1 - 5.6 7.1 28.4 0.51 10.4 3.8 3.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 BTB PF00651.31 KOS20756.1 - 3.7e-22 78.7 0.0 4.3e-11 43.0 0.1 2.8 3 0 0 3 3 3 2 BTB/POZ domain Ank_5 PF13857.6 KOS20756.1 - 3.2e-06 27.3 0.0 6.1e-05 23.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS20756.1 - 1.7e-05 25.3 0.1 4.6e-05 23.9 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS20756.1 - 0.00014 22.3 0.1 0.0006 20.3 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOS20756.1 - 0.0066 16.8 0.1 0.032 14.7 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 KOS20756.1 - 0.0075 16.7 0.3 0.17 12.5 0.1 3.3 3 0 0 3 3 3 1 Ankyrin repeat Choline_kinase PF01633.20 KOS20757.1 - 9.4e-59 198.6 0.0 1.5e-58 197.9 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 KOS20757.1 - 1.8e-17 62.7 0.1 3.5e-17 61.8 0.1 1.5 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 KOS20757.1 - 1.1e-05 25.5 0.2 1.1e-05 25.5 0.2 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Hydrolase_6 PF13344.6 KOS20758.1 - 3.1e-19 69.0 0.0 7.3e-19 67.8 0.0 1.6 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS20758.1 - 4.2e-18 65.2 0.1 9.2e-18 64.1 0.1 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 KOS20758.1 - 5.5e-06 26.8 0.0 0.15 12.3 0.0 3.3 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HET PF06985.11 KOS20759.1 - 7.8e-30 104.1 1.0 1.4e-29 103.3 1.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) EST1_DNA_bind PF10373.9 KOS20760.1 - 3.8e-15 56.1 0.0 9.1e-15 54.9 0.0 1.6 1 1 0 1 1 1 1 Est1 DNA/RNA binding domain ERAP1_C PF11838.8 KOS20760.1 - 0.035 13.7 0.2 0.056 13.0 0.2 1.2 1 0 0 1 1 1 0 ERAP1-like C-terminal domain FSA_C PF10479.9 KOS20760.1 - 0.039 12.1 5.9 0.057 11.5 5.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus AJAP1_PANP_C PF15298.6 KOS20760.1 - 0.57 10.4 7.9 1.6 8.9 7.9 1.7 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3439 PF11921.8 KOS20760.1 - 2.3 8.2 9.4 5.9 6.9 9.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Glyco_hydro_18 PF00704.28 KOS20761.1 - 6e-30 105.1 0.0 9.3e-30 104.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Glyco_hydro_85 PF03644.13 KOS20761.1 - 0.015 14.7 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 DUF4470 PF14737.6 KOS20762.1 - 0.0031 17.7 0.0 0.0063 16.7 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4470) DUF3915 PF13054.6 KOS20762.1 - 0.12 12.4 3.7 1.4 8.9 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Ripply PF14998.6 KOS20762.1 - 4.3 8.0 7.2 0.31 11.7 1.2 2.2 3 0 0 3 3 3 0 Transcription Regulator RNA_polI_A34 PF08208.11 KOS20762.1 - 5.1 7.1 20.8 3 7.9 7.3 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 CRCB PF02537.15 KOS20763.1 - 4.9e-35 119.7 17.1 1.2e-21 76.8 7.6 2.4 2 0 0 2 2 2 2 CrcB-like protein, Camphor Resistance (CrcB) GMC_oxred_N PF00732.19 KOS20764.1 - 3.3e-48 164.6 0.0 4.4e-48 164.2 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS20764.1 - 4.2e-27 95.4 0.0 1.2e-26 94.0 0.0 1.8 2 0 0 2 2 2 1 GMC oxidoreductase DAO PF01266.24 KOS20764.1 - 3e-07 30.4 0.8 2.5e-06 27.3 0.8 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS20764.1 - 1.4e-05 24.5 0.0 0.00017 21.0 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOS20764.1 - 1.8e-05 24.0 0.0 2.7e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_3 PF13738.6 KOS20764.1 - 0.00045 19.6 0.0 0.51 9.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS20764.1 - 0.00066 19.9 0.0 0.0022 18.2 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 KOS20764.1 - 0.0041 16.3 0.0 0.54 9.3 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 KOS20764.1 - 0.0069 16.4 0.3 0.056 13.4 0.0 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 KOS20764.1 - 0.012 14.8 1.5 0.16 11.0 0.1 2.3 2 1 0 2 2 2 0 FAD binding domain Amino_oxidase PF01593.24 KOS20764.1 - 0.016 14.6 0.0 0.028 13.7 0.0 1.4 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase HI0933_like PF03486.14 KOS20764.1 - 0.018 13.7 0.1 0.075 11.7 0.1 1.8 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 KOS20764.1 - 0.15 11.3 0.1 0.24 10.6 0.1 1.3 1 0 0 1 1 1 0 Thi4 family LigB PF02900.18 KOS20765.1 - 2.8e-25 88.9 0.0 4.3e-25 88.3 0.0 1.3 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Amidohydro_3 PF07969.11 KOS20766.1 - 1.4e-16 61.0 0.7 4.8e-12 46.1 0.0 2.6 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_1 PF01979.20 KOS20766.1 - 5.7e-13 48.9 2.6 1.3e-10 41.2 0.6 3.9 3 1 0 3 3 3 2 Amidohydrolase family GST_C_3 PF14497.6 KOS20767.1 - 4.5e-07 30.0 0.0 9e-07 29.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOS20767.1 - 0.013 15.5 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Pneumo_att_G PF05539.11 KOS20767.1 - 1.1 8.8 5.3 1.4 8.4 5.3 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Methyltransf_25 PF13649.6 KOS20768.1 - 0.0033 18.1 0.1 0.015 16.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS20768.1 - 0.014 16.1 0.0 0.068 13.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain NUDIX PF00293.28 KOS20768.1 - 0.047 13.7 0.0 0.13 12.3 0.0 1.7 1 0 0 1 1 1 0 NUDIX domain FA_desaturase PF00487.24 KOS20769.1 - 1.3e-12 48.2 32.2 1.3e-12 48.2 32.2 1.5 1 1 0 1 1 1 1 Fatty acid desaturase MIP PF00230.20 KOS20770.1 - 1.2e-31 110.2 6.9 1.8e-31 109.6 6.9 1.2 1 0 0 1 1 1 1 Major intrinsic protein FMO-like PF00743.19 KOS20772.1 - 0.0002 19.9 0.0 0.0015 17.1 0.0 2.1 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 KOS20772.1 - 0.00026 20.3 0.0 0.017 14.4 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS20772.1 - 0.00041 19.7 0.0 0.0038 16.5 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS20772.1 - 0.0072 15.5 0.0 0.15 11.2 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOS20772.1 - 0.0079 16.4 0.0 0.029 14.6 0.0 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Shikimate_DH PF01488.20 KOS20772.1 - 0.07 13.2 0.0 0.45 10.6 0.0 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase NAD_binding_9 PF13454.6 KOS20772.1 - 0.13 12.2 0.0 7.4 6.5 0.0 2.7 3 0 0 3 3 3 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 KOS20772.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ecm29 PF13001.7 KOS20773.1 - 8.3e-107 357.9 0.9 2.3e-105 353.1 0.2 2.7 2 0 0 2 2 2 1 Proteasome stabiliser IFRD PF05004.13 KOS20773.1 - 0.00066 18.9 0.5 3.5 6.7 0.0 5.2 6 1 0 6 6 6 1 Interferon-related developmental regulator (IFRD) MMS19_C PF12460.8 KOS20773.1 - 0.013 14.6 0.0 1.1 8.2 0.0 3.6 4 0 0 4 4 4 0 RNAPII transcription regulator C-terminal DUF3535 PF12054.8 KOS20773.1 - 0.18 11.0 1.2 20 4.3 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF3535) HEAT_EZ PF13513.6 KOS20773.1 - 1.1 9.9 10.9 14 6.3 0.0 6.8 6 1 2 8 8 8 0 HEAT-like repeat RRM_1 PF00076.22 KOS20774.1 - 2.7e-45 152.1 0.0 1.2e-16 60.3 0.0 3.1 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS20774.1 - 2.5e-07 30.6 0.1 0.0019 18.1 0.1 3.1 3 0 0 3 3 3 2 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 KOS20774.1 - 0.00014 21.8 0.0 0.0014 18.6 0.0 2.4 3 0 0 3 3 3 1 RNA binding motif RRM_7 PF16367.5 KOS20774.1 - 0.00015 21.8 0.1 0.046 13.9 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif RRM_occluded PF16842.5 KOS20774.1 - 0.00044 20.0 0.0 0.043 13.7 0.0 3.0 3 0 0 3 3 3 1 Occluded RNA-recognition motif RRM_5 PF13893.6 KOS20774.1 - 0.038 13.6 0.0 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Thioredoxin_7 PF13899.6 KOS20775.1 - 2.4e-17 62.9 0.1 6.1e-17 61.6 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like UBA_4 PF14555.6 KOS20775.1 - 2.8e-11 43.1 0.0 6.3e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 KOS20775.1 - 7.1e-05 22.9 0.0 0.00013 22.1 0.0 1.5 1 0 0 1 1 1 1 UBX domain Thioredox_DsbH PF03190.15 KOS20775.1 - 0.021 14.8 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF255 DUF2457 PF10446.9 KOS20775.1 - 0.074 12.2 9.8 0.63 9.1 10.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Thioredoxin_2 PF13098.6 KOS20775.1 - 0.08 13.4 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Iso_dh PF00180.20 KOS20776.1 - 3.9e-81 272.9 0.0 4.8e-81 272.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase RC-P840_PscD PF10657.9 KOS20776.1 - 0.11 12.6 0.0 0.71 10.0 0.0 2.0 2 0 0 2 2 2 0 Photosystem P840 reaction centre protein PscD zf-C2H2 PF00096.26 KOS20777.1 - 7.4e-14 51.3 12.4 2.5e-06 27.6 2.4 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS20777.1 - 1.3e-13 50.7 7.9 1.3e-07 31.7 0.2 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS20777.1 - 2.7e-09 37.1 11.5 0.00028 21.5 1.5 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 KOS20777.1 - 1.6e-08 34.3 7.2 0.00022 21.1 0.3 4.1 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOS20777.1 - 3.7e-07 30.3 0.3 0.061 13.6 0.1 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS20777.1 - 7.9e-05 22.9 5.2 0.0092 16.3 0.2 3.9 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KOS20777.1 - 0.0028 17.4 5.4 0.29 10.9 0.7 3.4 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-Di19 PF05605.12 KOS20777.1 - 0.05 13.9 1.4 0.09 13.1 1.4 1.4 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HE PF16278.5 KOS20777.1 - 0.23 11.9 3.4 5.8 7.4 0.5 2.7 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn_ribbon_recom PF13408.6 KOS20777.1 - 0.44 11.1 3.2 0.18 12.4 0.5 1.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain LIM PF00412.22 KOS20777.1 - 0.54 10.5 5.6 10 6.5 0.2 2.7 2 1 1 3 3 3 0 LIM domain FYVE PF01363.21 KOS20777.1 - 0.88 9.7 4.3 1.7 8.8 4.3 1.5 1 0 0 1 1 1 0 FYVE zinc finger C5HCH PF17982.1 KOS20777.1 - 2.1 8.6 6.8 18 5.5 1.1 2.5 1 1 1 2 2 2 0 NSD Cys-His rich domain TMF_TATA_bd PF12325.8 KOS20778.1 - 1.3e-38 131.8 2.7 1.3e-38 131.8 2.7 6.1 2 1 4 6 6 6 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 KOS20778.1 - 8.4e-12 44.9 10.7 8.4e-12 44.9 10.7 8.4 6 2 2 9 9 9 1 TATA element modulatory factor 1 DNA binding ATG16 PF08614.11 KOS20778.1 - 0.013 15.7 0.3 0.013 15.7 0.3 5.1 2 1 3 5 5 5 0 Autophagy protein 16 (ATG16) Holin_BhlA PF10960.8 KOS20778.1 - 0.72 9.9 0.0 0.72 9.9 0.0 3.2 5 0 0 5 5 5 0 BhlA holin family NPV_P10 PF05531.12 KOS20778.1 - 2.7 8.5 9.5 12 6.4 0.1 5.1 5 1 1 6 6 6 0 Nucleopolyhedrovirus P10 protein Ank_2 PF12796.7 KOS20779.1 - 4.2e-50 168.3 0.3 2.5e-15 56.8 0.2 3.4 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOS20779.1 - 3.6e-41 138.7 8.8 5.1e-10 39.4 0.2 5.2 1 1 5 6 6 6 6 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOS20779.1 - 2.3e-36 123.7 3.2 2.3e-09 37.6 0.0 4.8 1 1 4 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS20779.1 - 5.1e-33 109.4 0.1 4.8e-05 23.4 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat Ank PF00023.30 KOS20779.1 - 3.4e-28 96.8 0.9 4.6e-05 23.7 0.0 6.2 6 0 0 6 6 6 6 Ankyrin repeat WD40 PF00400.32 KOS20780.1 - 3.7e-44 147.8 21.0 6.7e-09 36.2 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20780.1 - 1.6e-05 25.1 0.4 16 5.8 0.0 5.3 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20780.1 - 0.022 13.5 2.3 12 4.4 0.0 3.9 1 1 3 4 4 4 0 Nucleoporin Nup120/160 W_rich_C PF07483.11 KOS20780.1 - 0.17 12.1 0.7 1.1 9.5 0.1 2.5 3 0 0 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain Peroxidase_2 PF01328.17 KOS20781.1 - 8.5e-23 81.8 0.0 1e-22 81.6 0.0 1.0 1 0 0 1 1 1 1 Peroxidase, family 2 AAA PF00004.29 KOS20782.1 - 1e-15 58.4 0.0 2.2e-15 57.3 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOS20782.1 - 1.3e-11 45.2 0.2 8.8e-10 39.2 0.0 3.2 2 2 0 2 2 2 1 AAA ATPase domain AAA_lid_10 PF17872.1 KOS20782.1 - 3.3e-11 43.2 0.2 8.2e-11 41.9 0.2 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 KOS20782.1 - 6.5e-10 39.4 0.0 1.4e-09 38.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain BAH PF01426.18 KOS20782.1 - 1.5e-09 37.8 0.0 3.2e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 BAH domain AAA_19 PF13245.6 KOS20782.1 - 0.00031 21.1 0.1 0.0016 18.8 0.0 2.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 KOS20782.1 - 0.0058 16.6 0.0 0.074 12.9 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 KOS20782.1 - 0.013 16.1 0.0 0.028 15.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 KOS20782.1 - 0.021 14.6 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS20782.1 - 0.041 13.8 0.0 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 KOS20782.1 - 0.041 14.1 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 KOS20782.1 - 0.047 13.4 0.0 0.099 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOS20782.1 - 0.052 12.8 0.0 0.083 12.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 KOS20782.1 - 0.099 13.0 0.0 0.39 11.1 0.0 2.1 1 0 0 1 1 1 0 RNA helicase AAA_32 PF13654.6 KOS20782.1 - 0.17 10.6 0.0 0.27 10.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain Prefoldin PF02996.17 KOS20783.1 - 5.1e-23 81.3 0.2 6.6e-23 80.9 0.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit UvsW PF11637.8 KOS20783.1 - 0.0054 16.8 0.4 0.014 15.5 0.4 1.8 1 1 0 1 1 1 1 ATP-dependant DNA helicase UvsW TACC_C PF05010.14 KOS20783.1 - 0.0077 16.0 8.0 0.24 11.2 2.5 2.1 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Prot_ATP_ID_OB PF16450.5 KOS20783.1 - 0.015 15.2 0.1 0.03 14.3 0.1 1.4 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Prefoldin_2 PF01920.20 KOS20783.1 - 0.021 14.7 5.1 0.27 11.2 0.9 2.1 2 0 0 2 2 2 0 Prefoldin subunit Fib_alpha PF08702.10 KOS20783.1 - 0.034 14.3 0.9 2.8 8.1 0.3 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GIT_CC PF16559.5 KOS20783.1 - 0.065 13.1 0.6 0.065 13.1 0.6 1.9 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2080 PF09853.9 KOS20783.1 - 0.11 12.3 0.4 0.3 10.9 0.0 1.8 2 0 0 2 2 2 0 Putative transposon-encoded protein (DUF2080) CLZ PF16526.5 KOS20783.1 - 0.18 12.1 5.9 5.2 7.5 1.0 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Sec2p PF06428.11 KOS20783.1 - 0.3 11.1 6.5 4 7.5 0.2 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p HGTP_anticodon PF03129.20 KOS20784.1 - 2.6e-09 37.1 0.0 4.5e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 KOS20784.1 - 6.9e-09 35.9 0.0 1.1e-08 35.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Zn_Tnp_IS1595 PF12760.7 KOS20784.1 - 0.076 13.0 0.1 0.89 9.6 0.0 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain eIF3_subunit PF08597.10 KOS20785.1 - 2.9e-70 236.9 27.9 3.3e-70 236.8 27.9 1.0 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit PRP4 PF08799.11 KOS20785.1 - 0.8 9.3 5.3 1.7 8.3 5.3 1.6 1 0 0 1 1 1 0 pre-mRNA processing factor 4 (PRP4) like AOX PF01786.17 KOS20786.1 - 6e-82 274.4 0.4 7.3e-82 274.1 0.4 1.1 1 0 0 1 1 1 1 Alternative oxidase COQ7 PF03232.13 KOS20786.1 - 0.038 13.7 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 IMD PF08397.11 KOS20787.1 - 5.9e-05 22.5 1.5 0.0068 15.8 0.1 2.2 2 0 0 2 2 2 2 IRSp53/MIM homology domain PPP4R2 PF09184.11 KOS20787.1 - 0.056 13.0 4.1 0.089 12.4 4.1 1.3 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 KOS20787.1 - 0.91 7.7 9.8 1.3 7.1 9.8 1.1 1 0 0 1 1 1 0 Nop14-like family WRNPLPNID PF15017.6 KOS20787.1 - 1 10.3 12.5 3.2 8.7 12.5 1.8 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box NOA36 PF06524.12 KOS20787.1 - 2.1 7.6 11.3 3.3 6.9 11.3 1.2 1 0 0 1 1 1 0 NOA36 protein Prothymosin PF03247.14 KOS20787.1 - 2.1 8.8 21.5 4.5 7.8 21.5 1.5 1 0 0 1 1 1 0 Prothymosin/parathymosin family CDC45 PF02724.14 KOS20787.1 - 4 5.6 11.0 7.7 4.7 11.0 1.4 1 0 0 1 1 1 0 CDC45-like protein TFIIA PF03153.13 KOS20790.1 - 7.4 6.4 15.2 9.6 6.1 15.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ThiF PF00899.21 KOS20791.1 - 1.6e-40 139.0 0.0 2.5e-40 138.4 0.0 1.2 1 0 0 1 1 1 1 ThiF family Sacchrp_dh_NADP PF03435.18 KOS20791.1 - 0.0022 18.2 0.3 0.02 15.2 0.3 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 KOS20791.1 - 0.0037 17.5 0.1 0.0086 16.3 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 KOS20791.1 - 0.011 15.4 0.2 0.02 14.5 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain ApbA PF02558.16 KOS20791.1 - 0.055 13.1 0.1 0.096 12.3 0.1 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 KOS20791.1 - 0.1 12.7 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain SR-25 PF10500.9 KOS20792.1 - 7.7e-05 22.4 12.3 7.7e-05 22.4 12.3 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein TPR_14 PF13428.6 KOS20792.1 - 0.0049 17.6 6.4 1.1 10.2 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS20792.1 - 0.022 15.4 4.3 6.3 7.5 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOS20792.1 - 0.11 12.8 2.2 10 6.5 0.0 3.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Pacs-1 PF10254.9 KOS20792.1 - 0.15 11.0 3.1 0.24 10.3 3.1 1.2 1 0 0 1 1 1 0 PACS-1 cytosolic sorting protein Apt1 PF10351.9 KOS20792.1 - 4.4 6.1 6.8 7.5 5.3 6.8 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain TPR_2 PF07719.17 KOS20793.1 - 6.6e-07 29.0 8.5 0.0058 16.7 0.0 6.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOS20793.1 - 0.00012 21.8 0.0 0.11 12.4 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS20793.1 - 0.00014 22.4 19.3 8.8 7.4 0.1 8.0 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS20793.1 - 0.00017 22.0 9.2 0.21 12.1 0.0 5.5 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOS20793.1 - 0.00035 20.2 0.8 1.9 8.3 0.0 4.4 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.6 KOS20793.1 - 0.00058 20.5 27.6 0.0031 18.1 0.1 7.6 8 1 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOS20793.1 - 0.0012 18.7 0.1 0.91 9.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS20793.1 - 0.002 18.4 8.6 6.6 7.1 0.6 5.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOS20793.1 - 0.12 12.8 1.2 1.1e+02 3.5 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat QRPTase_C PF01729.19 KOS20794.1 - 8.7e-54 181.8 0.1 1.1e-53 181.5 0.1 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 KOS20794.1 - 3.5e-16 59.0 0.0 1.4e-15 57.1 0.0 2.1 2 0 0 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain Sugar_tr PF00083.24 KOS20795.1 - 1.2e-76 258.4 21.9 1.4e-76 258.3 21.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS20795.1 - 6.6e-16 58.2 31.2 6.6e-16 58.2 31.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily FAD_binding_3 PF01494.19 KOS20796.1 - 1e-16 61.2 0.5 1.5e-16 60.6 0.5 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS20796.1 - 0.0001 22.1 0.0 0.067 12.8 0.0 2.5 1 1 2 3 3 3 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS20796.1 - 0.00034 19.9 0.1 0.52 9.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS20796.1 - 0.00049 20.3 0.1 0.0012 19.1 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOS20796.1 - 0.0046 17.0 0.0 0.018 15.0 0.0 2.0 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 KOS20796.1 - 0.0064 15.6 0.1 1.2 8.1 0.0 2.7 1 1 2 3 3 3 2 FAD binding domain Pyr_redox PF00070.27 KOS20796.1 - 0.022 15.3 0.0 0.076 13.6 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS20796.1 - 0.045 12.6 0.5 0.32 9.8 0.1 2.3 3 0 0 3 3 3 0 Tryptophan halogenase RabGAP-TBC PF00566.18 KOS20797.1 - 8.1e-32 110.6 0.0 2.7e-31 108.9 0.0 1.8 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Sulfate_transp PF00916.20 KOS20798.1 - 1.9e-108 362.6 21.5 2.6e-108 362.2 21.5 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOS20798.1 - 4.7e-08 32.7 0.0 9.3e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KOS20798.1 - 0.0034 17.8 3.4 0.0034 17.8 3.4 3.5 2 2 0 2 2 2 1 Molybdate transporter of MFS superfamily DUF2937 PF11157.8 KOS20798.1 - 1.6 8.5 5.0 5.2 6.8 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) FmiP_Thoc5 PF09766.9 KOS20799.1 - 3.7e-30 105.4 14.5 4.9e-30 105.0 14.5 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 SPATA1_C PF15743.5 KOS20799.1 - 0.003 17.6 5.3 0.003 17.6 5.3 2.3 2 1 0 2 2 2 1 Spermatogenesis-associated C-terminus Casc1_N PF15927.5 KOS20799.1 - 0.0061 16.3 9.1 0.0061 16.3 9.1 2.1 2 1 0 2 2 2 1 Cancer susceptibility candidate 1 N-terminus CENP-F_leu_zip PF10473.9 KOS20799.1 - 0.05 13.6 10.6 0.79 9.7 4.5 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 KOS20799.1 - 0.085 12.9 3.7 0.35 10.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TSC22 PF01166.18 KOS20799.1 - 0.12 12.6 6.5 2 8.8 0.1 2.6 2 0 0 2 2 2 0 TSC-22/dip/bun family DUF3958 PF13125.6 KOS20799.1 - 0.44 10.8 16.1 3.5 7.9 12.6 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3958) Toxin_8 PF07365.12 KOS20799.1 - 0.67 10.2 3.0 0.62 10.3 1.0 2.0 2 0 0 2 2 2 0 Alpha conotoxin precursor DUF4200 PF13863.6 KOS20799.1 - 0.81 10.1 14.5 1 9.8 1.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) K-box PF01486.17 KOS20799.1 - 2 8.6 15.9 0.56 10.4 10.3 2.6 2 1 1 3 3 3 0 K-box region DUF4407 PF14362.6 KOS20799.1 - 5.8 6.2 11.5 8.9 5.6 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HlyIII PF03006.20 KOS20800.1 - 4.2e-58 196.7 21.1 5.2e-58 196.4 21.1 1.1 1 0 0 1 1 1 1 Haemolysin-III related Miga PF10265.9 KOS20800.1 - 0.083 11.9 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Mitoguardin MOSC PF03473.17 KOS20801.1 - 7.9e-39 132.7 0.0 1.5e-38 131.8 0.0 1.5 2 0 0 2 2 2 1 MOSC domain SSDP PF04503.13 KOS20801.1 - 0.0019 18.5 0.1 0.0024 18.2 0.1 1.2 1 0 0 1 1 1 1 Single-stranded DNA binding protein, SSDP ARS2 PF04959.13 KOS20802.1 - 9.4e-07 29.4 4.3 1.2e-06 29.1 4.3 1.1 1 0 0 1 1 1 1 Arsenite-resistance protein 2 zf-C2H2_aberr PF17017.5 KOS20802.1 - 0.067 13.3 0.0 0.093 12.9 0.0 1.3 1 0 0 1 1 1 0 Aberrant zinc-finger RRM_1 PF00076.22 KOS20803.1 - 1e-16 60.5 0.0 1.6e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA PF03153.13 KOS20803.1 - 0.012 15.6 15.2 0.015 15.3 15.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OB_RNB PF08206.11 KOS20803.1 - 0.14 11.9 0.4 0.34 10.6 0.4 1.6 1 0 0 1 1 1 0 Ribonuclease B OB domain Presenilin PF01080.17 KOS20803.1 - 1.6 7.4 5.9 2.3 6.9 5.9 1.2 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 KOS20803.1 - 1.9 7.9 14.3 6.9 6.0 12.4 2.0 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin PAT1 PF09770.9 KOS20803.1 - 4.8 5.3 18.5 6.5 4.9 18.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 KOS20803.1 - 7 6.6 5.9 1.8 8.5 2.9 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SWI-SNF_Ssr4 PF08549.10 KOS20804.1 - 1.4e-280 933.0 0.1 1.7e-280 932.8 0.1 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1750) Metal_resist PF13801.6 KOS20804.1 - 8.4 6.6 9.8 1.5 9.0 0.1 3.1 3 0 0 3 3 3 0 Heavy-metal resistance WLM PF08325.10 KOS20805.1 - 6.6e-30 104.6 0.1 1.4e-29 103.6 0.1 1.6 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.17 KOS20805.1 - 7.8e-07 29.3 0.2 1.5e-06 28.4 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF45 Cwf_Cwc_15 PF04889.12 KOS20805.1 - 0.11 12.3 3.3 0.14 11.8 3.3 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 KOS20805.1 - 1.8 6.7 6.4 2.2 6.4 6.4 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 KOS20805.1 - 7.7 5.7 9.2 12 5.1 9.2 1.2 1 0 0 1 1 1 0 NOA36 protein Zn_clus PF00172.18 KOS20806.1 - 3.1e-05 24.0 11.9 6.3e-05 23.0 11.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOS20806.1 - 0.00078 18.6 0.0 0.0022 17.1 0.0 1.7 1 0 0 1 1 1 1 Fungal specific transcription factor domain Yae1_N PF09811.9 KOS20806.1 - 0.051 13.3 1.4 0.098 12.4 1.4 1.5 1 0 0 1 1 1 0 Essential protein Yae1, N terminal NAD_binding_9 PF13454.6 KOS20807.1 - 2.7e-06 27.5 0.4 0.00065 19.7 1.1 3.2 2 1 0 2 2 2 1 FAD-NAD(P)-binding K_oxygenase PF13434.6 KOS20807.1 - 1.9e-05 24.0 0.2 0.0032 16.6 0.0 2.2 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 KOS20807.1 - 3.4e-05 23.2 0.5 0.00013 21.3 0.5 1.8 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS20807.1 - 0.0058 15.9 0.2 0.45 9.7 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase MLD PF11647.8 KOS20807.1 - 0.14 12.5 0.0 17 5.8 0.0 2.3 2 0 0 2 2 2 0 Membrane Localization Domain Fungal_trans PF04082.18 KOS20808.1 - 1.3e-14 53.9 0.0 2.1e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2207 PF09972.9 KOS20808.1 - 1.4 7.6 2.7 2.5 6.8 2.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Arrestin_C PF02752.22 KOS20809.1 - 2e-16 60.7 0.0 1.4e-15 57.9 0.0 2.3 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOS20809.1 - 1.3e-07 31.8 0.0 0.00061 19.9 0.0 2.4 2 0 0 2 2 2 2 Arrestin (or S-antigen), N-terminal domain DUF3261 PF11659.8 KOS20809.1 - 0.085 12.7 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3261) NUDIX PF00293.28 KOS20810.1 - 1.2e-15 57.8 1.9 2.5e-15 56.7 1.9 1.6 1 1 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 KOS20810.1 - 0.0034 17.4 0.0 0.0082 16.1 0.0 1.7 2 0 0 2 2 2 1 NUDIX domain CAP PF00188.26 KOS20812.1 - 4.9e-14 53.2 0.8 1.1e-13 52.1 0.8 1.5 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Reprolysin_4 PF13583.6 KOS20812.1 - 0.17 11.5 0.0 0.2 11.3 0.0 1.3 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Baculo_PEP_C PF04513.12 KOS20813.1 - 8.8e-06 25.8 5.5 0.00033 20.7 3.4 2.3 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1664 PF07889.12 KOS20813.1 - 9.2e-06 25.7 4.9 0.0056 16.7 0.9 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 KOS20813.1 - 2.5e-05 23.3 2.7 3.1e-05 23.0 2.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein ATG16 PF08614.11 KOS20813.1 - 0.00011 22.5 3.2 0.00015 22.1 3.2 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 KOS20813.1 - 0.00057 20.3 5.9 0.12 12.9 1.3 3.1 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein Fib_alpha PF08702.10 KOS20813.1 - 0.0011 19.2 2.0 0.0042 17.3 0.5 2.2 1 1 1 2 2 2 1 Fibrinogen alpha/beta chain family FPP PF05911.11 KOS20813.1 - 0.0013 17.1 0.9 0.0015 16.9 0.9 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil MscS_porin PF12795.7 KOS20813.1 - 0.0015 18.2 8.2 0.0038 16.8 8.3 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain DUF5082 PF16888.5 KOS20813.1 - 0.0015 18.8 4.1 0.28 11.5 0.2 3.1 1 1 2 3 3 3 1 Domain of unknown function (DUF5082) Prominin PF05478.11 KOS20813.1 - 0.0021 16.1 0.9 0.0024 15.9 0.9 1.1 1 0 0 1 1 1 1 Prominin DUF1515 PF07439.11 KOS20813.1 - 0.0034 17.4 4.0 0.024 14.6 1.7 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1515) HrpB7 PF09486.10 KOS20813.1 - 0.0039 17.6 14.9 0.0081 16.6 14.9 1.5 1 1 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) Fez1 PF06818.15 KOS20813.1 - 0.0053 17.2 2.4 0.024 15.1 2.1 1.9 1 1 1 2 2 2 1 Fez1 DUF2312 PF10073.9 KOS20813.1 - 0.0057 16.3 0.0 0.016 14.8 0.0 1.7 2 0 0 2 2 1 1 Uncharacterized protein conserved in bacteria (DUF2312) DELLA PF12041.8 KOS20813.1 - 0.0065 16.3 0.6 0.027 14.4 0.0 2.2 1 1 2 3 3 2 1 Transcriptional regulator DELLA protein N terminal DUF812 PF05667.11 KOS20813.1 - 0.0069 15.3 2.6 0.0088 15.0 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Myosin_tail_1 PF01576.19 KOS20813.1 - 0.012 13.4 1.0 0.015 13.2 1.0 1.1 1 0 0 1 1 1 0 Myosin tail DUF4407 PF14362.6 KOS20813.1 - 0.014 14.7 7.7 0.017 14.5 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_13 PF13166.6 KOS20813.1 - 0.016 13.9 3.1 0.017 13.8 3.1 1.1 1 0 0 1 1 1 0 AAA domain IMD PF08397.11 KOS20813.1 - 0.016 14.6 0.9 0.024 14.0 0.6 1.3 1 1 0 1 1 1 0 IRSp53/MIM homology domain Laminin_II PF06009.12 KOS20813.1 - 0.017 15.1 8.8 0.022 14.8 1.2 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF3584 PF12128.8 KOS20813.1 - 0.02 12.5 5.6 0.024 12.2 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FlaC_arch PF05377.11 KOS20813.1 - 0.02 15.3 1.0 8.1 6.9 0.1 3.2 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) EzrA PF06160.12 KOS20813.1 - 0.023 12.9 2.9 0.1 10.7 1.9 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA JAKMIP_CC3 PF16034.5 KOS20813.1 - 0.028 14.4 3.3 0.06 13.3 3.3 1.6 1 1 0 1 1 1 0 JAKMIP CC3 domain DUF211 PF02680.14 KOS20813.1 - 0.03 14.5 0.3 0.056 13.6 0.3 1.6 1 1 0 1 1 1 0 Uncharacterized ArCR, COG1888 KxDL PF10241.9 KOS20813.1 - 0.031 14.5 1.7 5.2 7.4 0.3 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein Syntaxin-6_N PF09177.11 KOS20813.1 - 0.032 14.8 1.4 0.63 10.6 0.3 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF4795 PF16043.5 KOS20813.1 - 0.033 13.8 2.5 0.23 11.1 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF2730 PF10805.8 KOS20813.1 - 0.038 14.1 1.1 0.87 9.7 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Tektin PF03148.14 KOS20813.1 - 0.047 12.4 4.4 3.1 6.4 1.7 1.9 1 1 0 1 1 1 0 Tektin family CCDC144C PF14915.6 KOS20813.1 - 0.049 12.7 2.3 0.06 12.4 2.3 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region Cob_adeno_trans PF01923.18 KOS20813.1 - 0.052 13.7 2.8 0.097 12.8 2.8 1.5 1 1 0 1 1 1 0 Cobalamin adenosyltransferase ApoO PF09769.9 KOS20813.1 - 0.053 13.5 1.0 1.5 8.8 0.0 2.7 1 1 1 2 2 2 0 Apolipoprotein O IFT57 PF10498.9 KOS20813.1 - 0.057 12.4 1.8 0.13 11.2 1.8 1.5 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Filament PF00038.21 KOS20813.1 - 0.062 12.9 5.3 0.13 11.8 5.3 1.5 1 1 0 1 1 1 0 Intermediate filament protein APG6_N PF17675.1 KOS20813.1 - 0.063 13.8 2.0 0.32 11.5 2.0 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Cast PF10174.9 KOS20813.1 - 0.063 11.5 3.3 0.082 11.1 3.3 1.2 1 0 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone GAS PF13851.6 KOS20813.1 - 0.065 12.6 1.7 0.2 11.0 1.7 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Rab5-bind PF09311.11 KOS20813.1 - 0.065 12.6 4.5 2.3 7.5 0.2 2.1 1 1 1 2 2 2 0 Rabaptin-like protein Tropomyosin_1 PF12718.7 KOS20813.1 - 0.067 13.3 0.4 0.46 10.6 0.0 2.0 2 0 0 2 2 2 0 Tropomyosin like CLZ PF16526.5 KOS20813.1 - 0.079 13.3 2.0 0.42 11.0 0.2 2.5 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Vps53_N PF04100.12 KOS20813.1 - 0.093 11.7 3.6 0.057 12.4 1.6 1.6 1 1 1 2 2 2 0 Vps53-like, N-terminal TMPIT PF07851.13 KOS20813.1 - 0.096 11.9 2.2 0.22 10.7 2.3 1.6 1 1 0 1 1 1 0 TMPIT-like protein DegQ PF08181.11 KOS20813.1 - 0.11 12.6 0.0 3.1 8.0 0.0 2.7 2 0 0 2 2 2 0 DegQ (SacQ) family Snf7 PF03357.21 KOS20813.1 - 0.11 12.1 6.4 1.7 8.2 3.5 2.5 1 1 1 2 2 2 0 Snf7 PIN_8 PF18476.1 KOS20813.1 - 0.12 12.2 3.7 0.3 10.9 0.8 1.9 1 1 1 2 2 2 0 PIN like domain HIP1_clath_bdg PF16515.5 KOS20813.1 - 0.13 12.9 5.3 0.39 11.4 3.4 2.5 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PI3K_P85_iSH2 PF16454.5 KOS20813.1 - 0.13 11.8 1.3 1.2 8.7 1.3 2.2 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Snapin_Pallidin PF14712.6 KOS20813.1 - 0.15 12.5 4.3 0.57 10.6 0.7 2.4 1 1 0 2 2 2 0 Snapin/Pallidin THOC7 PF05615.13 KOS20813.1 - 0.16 12.3 6.3 0.97 9.7 6.3 2.2 1 1 0 1 1 1 0 Tho complex subunit 7 zf-C4H2 PF10146.9 KOS20813.1 - 0.17 12.2 1.7 2.9 8.1 1.9 1.9 1 1 0 1 1 1 0 Zinc finger-containing protein DUF842 PF05811.13 KOS20813.1 - 0.2 11.3 4.9 0.59 9.8 1.2 2.1 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF842) COG2 PF06148.11 KOS20813.1 - 0.22 11.6 4.2 0.63 10.1 1.0 2.6 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF724 PF05266.14 KOS20813.1 - 0.26 11.1 3.4 0.78 9.5 3.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) YlqD PF11068.8 KOS20813.1 - 0.27 11.6 4.9 3.1 8.2 4.9 2.1 1 1 0 1 1 1 0 YlqD protein Cluap1 PF10234.9 KOS20813.1 - 0.28 10.5 3.9 1.1 8.5 3.9 1.9 1 1 0 1 1 1 0 Clusterin-associated protein-1 Atg14 PF10186.9 KOS20813.1 - 0.28 10.2 2.7 0.38 9.8 2.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4061 PF13270.6 KOS20813.1 - 0.29 11.5 2.9 0.54 10.6 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) DASH_Duo1 PF08651.10 KOS20813.1 - 0.29 10.9 3.0 3.6 7.4 0.2 3.1 1 1 1 3 3 3 0 DASH complex subunit Duo1 FliJ PF02050.16 KOS20813.1 - 0.32 11.2 9.8 0.33 11.2 3.2 2.2 1 1 1 2 2 2 0 Flagellar FliJ protein DUF3450 PF11932.8 KOS20813.1 - 0.59 9.4 9.3 1.1 8.5 9.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DHR10 PF18595.1 KOS20813.1 - 0.67 10.0 7.8 0.5 10.4 1.7 2.5 1 1 0 2 2 2 0 Designed helical repeat protein 10 domain Phage_Mu_Gam PF07352.12 KOS20813.1 - 1.1 9.2 4.1 2.3 8.1 0.4 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein TPR_MLP1_2 PF07926.12 KOS20813.1 - 1.8 8.6 9.9 29 4.7 9.6 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein CorA PF01544.18 KOS20813.1 - 3.6 6.8 5.4 31 3.7 0.1 2.4 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Sugar_tr PF00083.24 KOS20815.1 - 5.8e-29 101.3 31.7 1.8e-17 63.4 9.7 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOS20815.1 - 5.4e-24 84.8 30.0 7.4e-17 61.3 14.0 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF1774 PF08611.10 KOS20815.1 - 0.18 12.2 1.4 0.47 10.8 1.4 1.7 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) Fungal_trans PF04082.18 KOS20816.1 - 5.8e-19 68.1 0.1 9.3e-19 67.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS20816.1 - 5.5e-07 29.6 14.3 5.5e-07 29.6 14.3 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SH3_6 PF12913.7 KOS20816.1 - 0.18 11.4 0.1 0.51 9.9 0.1 1.7 1 0 0 1 1 1 0 SH3 domain (SH3b1 type) WD40 PF00400.32 KOS20817.1 - 1.3e-15 57.5 0.1 0.0037 18.1 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20817.1 - 7.1e-06 26.2 0.0 13 6.2 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20817.1 - 0.0023 16.6 0.3 0.1 11.2 0.1 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Cyclin_N PF00134.23 KOS20818.1 - 1.4e-43 147.7 0.1 3e-43 146.6 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 KOS20818.1 - 1.8e-33 115.1 0.1 1.8e-33 115.1 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain HEPN_Toprim_N PF18871.1 KOS20818.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 Mitofilin PF09731.9 KOS20818.1 - 3 6.6 29.4 4.7 5.9 29.4 1.3 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Nop PF01798.18 KOS20819.1 - 2.5e-71 239.8 0.0 3.6e-71 239.3 0.0 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 KOS20819.1 - 1e-45 155.5 1.1 1e-45 155.5 1.1 2.2 3 0 0 3 3 3 1 Prp31 C terminal domain RRN3 PF05327.11 KOS20819.1 - 1.6 7.2 2.6 2.3 6.7 2.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-C2H2 PF00096.26 KOS20820.1 - 0.00037 20.8 12.7 0.0025 18.2 0.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS20820.1 - 0.0099 16.3 1.3 0.0099 16.3 1.3 2.8 3 1 0 3 3 3 1 Zinc-finger double domain Integrin_B_tail PF07965.12 KOS20820.1 - 0.029 14.8 2.1 0.041 14.4 0.6 1.9 1 1 1 2 2 2 0 Integrin beta tail domain zf-met PF12874.7 KOS20820.1 - 0.067 13.6 6.1 0.35 11.3 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KOS20820.1 - 0.17 12.8 0.7 0.17 12.8 0.7 3.0 3 0 0 3 3 3 0 C2H2-type zinc finger Acetate_kinase PF00871.17 KOS20821.1 - 5.4e-72 242.6 0.0 1.3e-71 241.4 0.0 1.7 1 1 0 1 1 1 1 Acetokinase family TPR_14 PF13428.6 KOS20824.1 - 6.3e-21 73.3 36.9 5.5e-05 23.6 0.0 10.6 8 3 3 11 11 10 5 Tetratricopeptide repeat HAT PF02184.16 KOS20824.1 - 1.2e-18 66.8 13.4 3.4e-11 42.9 2.2 13.0 14 1 0 14 14 13 4 HAT (Half-A-TPR) repeat TPR_19 PF14559.6 KOS20824.1 - 7.8e-17 61.6 3.8 2.7e-05 24.6 0.0 7.3 7 1 2 9 9 9 3 Tetratricopeptide repeat Suf PF05843.14 KOS20824.1 - 3.3e-14 53.6 12.3 0.0034 17.4 0.1 5.8 3 3 1 5 5 5 3 Suppressor of forked protein (Suf) TPR_17 PF13431.6 KOS20824.1 - 5.1e-10 39.0 4.7 0.81 10.2 0.0 6.5 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 KOS20824.1 - 1.5e-07 31.0 13.1 0.1 11.8 1.0 5.3 3 2 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 KOS20824.1 - 2e-06 28.0 12.4 27 5.7 0.0 7.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOS20824.1 - 1.5e-05 24.8 0.9 3.7 8.0 0.0 5.4 4 0 0 4 4 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 KOS20824.1 - 0.00027 20.2 22.3 0.11 11.6 0.4 6.1 4 3 1 6 6 6 3 NRDE-2, necessary for RNA interference TPR_2 PF07719.17 KOS20824.1 - 0.00048 20.0 18.3 3.2 8.1 0.0 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 KOS20824.1 - 0.0049 16.9 18.9 0.11 12.6 0.3 7.1 4 3 3 7 7 7 1 U3 small nucleolar RNA-associated protein 6 Fis1_TPR_C PF14853.6 KOS20824.1 - 0.031 14.3 5.1 18 5.5 0.5 4.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 KOS20824.1 - 0.078 13.6 22.4 6.4 7.5 0.0 8.1 10 2 2 12 12 9 0 Tetratricopeptide repeat TPR_1 PF00515.28 KOS20824.1 - 0.2 11.6 1.8 65 3.6 0.5 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat FAM176 PF14851.6 KOS20824.1 - 0.62 9.7 3.9 2.2 7.9 3.9 1.9 1 0 0 1 1 1 0 FAM176 family Sigma70_ner PF04546.13 KOS20824.1 - 0.89 9.4 10.1 0.12 12.2 5.5 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 KOS20824.1 - 1.3 9.4 9.3 3.9 7.9 9.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain c-SKI_SMAD_bind PF08782.10 KOS20824.1 - 2.3 8.5 4.9 8.3 6.7 0.1 3.9 4 0 0 4 4 4 0 c-SKI Smad4 binding domain NOA36 PF06524.12 KOS20824.1 - 2.3 7.5 10.3 3.9 6.7 10.3 1.3 1 0 0 1 1 1 0 NOA36 protein ECSIT PF06239.11 KOS20824.1 - 5.1 6.2 9.7 2.3 7.3 0.0 3.4 4 0 0 4 4 4 0 Evolutionarily conserved signalling intermediate in Toll pathway Glyco_hydro_18 PF00704.28 KOS20825.1 - 6e-65 220.0 0.0 6.9e-65 219.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Lipase_GDSL_2 PF13472.6 KOS20825.1 - 0.08 13.3 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Rad9 PF04139.13 KOS20826.1 - 3.2e-45 154.6 0.2 3.9e-45 154.3 0.2 1.1 1 0 0 1 1 1 1 Rad9 FAR1 PF03101.15 KOS20827.1 - 4e-06 27.4 0.1 7.1e-06 26.6 0.1 1.3 1 0 0 1 1 1 1 FAR1 DNA-binding domain Sugarporin_N PF11471.8 KOS20827.1 - 8.9e-05 22.4 0.5 0.0024 17.8 0.0 2.3 1 1 1 2 2 2 2 Maltoporin periplasmic N-terminal extension AFT PF08731.11 KOS20827.1 - 0.0086 16.5 0.1 0.013 15.9 0.1 1.4 1 0 0 1 1 1 1 Transcription factor AFT XhlA PF10779.9 KOS20827.1 - 0.02 15.1 0.0 0.063 13.5 0.0 1.8 1 1 1 2 2 2 0 Haemolysin XhlA Snapin_Pallidin PF14712.6 KOS20827.1 - 0.088 13.2 0.1 0.23 11.9 0.1 1.7 1 1 0 1 1 1 0 Snapin/Pallidin OmpH PF03938.14 KOS20827.1 - 0.11 12.8 0.7 11 6.4 0.1 2.4 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) CLZ PF16526.5 KOS20827.1 - 0.12 12.8 0.3 0.74 10.2 0.1 2.0 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels MtrG PF04210.13 KOS20827.1 - 0.17 11.7 0.0 0.45 10.4 0.0 1.6 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G Hemagglutinin PF00509.18 KOS20827.1 - 0.23 9.8 0.0 0.31 9.4 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin HSBP1 PF06825.12 KOS20827.1 - 1.5 8.7 9.1 1.3 9.0 1.1 2.8 3 1 0 3 3 3 0 Heat shock factor binding protein 1 Mpv17_PMP22 PF04117.12 KOS20829.1 - 1.1e-09 38.3 2.1 3.8e-09 36.6 2.0 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family FANCI_S2 PF14676.6 KOS20829.1 - 0.073 13.4 0.2 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 FANCI solenoid 2 RCC1 PF00415.18 KOS20830.1 - 1e-25 90.1 15.4 4.1e-11 43.3 0.0 7.1 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 KOS20830.1 - 1.2e-16 60.0 26.0 1.4e-05 24.8 1.3 6.0 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat PDH PF02153.17 KOS20831.1 - 7.3e-14 51.4 0.0 1e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase VIR_N PF15912.5 KOS20831.1 - 0.57 9.7 2.5 66 3.0 4.7 2.1 2 0 0 2 2 2 0 Virilizer, N-terminal HAD PF12710.7 KOS20832.1 - 6.6e-24 85.3 0.2 1.2e-23 84.5 0.2 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS20832.1 - 1.8e-15 57.8 0.1 3.1e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOS20832.1 - 3.4e-08 33.5 1.4 1.4e-07 31.5 0.1 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOS20832.1 - 0.0012 19.0 0.0 0.015 15.4 0.0 2.4 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase DUF705 PF05152.12 KOS20832.1 - 0.016 14.7 0.1 0.024 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF705) Put_Phosphatase PF06888.12 KOS20832.1 - 0.054 12.9 0.0 4.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Putative Phosphatase E3_binding PF02817.17 KOS20832.1 - 0.055 13.8 0.4 7.6 7.0 0.1 2.8 2 0 0 2 2 2 0 e3 binding domain FAM25 PF15825.5 KOS20832.1 - 0.23 11.8 2.9 0.49 10.8 2.9 1.5 1 0 0 1 1 1 0 FAM25 family RRM_1 PF00076.22 KOS20834.1 - 3e-15 55.8 0.0 4.2e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 KOS20834.1 - 0.014 15.0 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transpeptidase PF00905.22 KOS20834.1 - 0.13 11.5 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain p450 PF00067.22 KOS20835.1 - 1e-58 199.2 0.0 1.4e-58 198.8 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Glyco_hydro_47 PF01532.20 KOS20836.1 - 8.6e-162 539.2 0.0 1e-161 539.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 TP_methylase PF00590.20 KOS20837.1 - 1.3e-45 155.9 1.7 3.5e-45 154.5 1.7 1.7 1 1 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases NAD_binding_7 PF13241.6 KOS20837.1 - 6.8e-13 49.0 0.0 1.4e-12 47.9 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 KOS20837.1 - 1.9e-11 43.2 0.2 1.9e-11 43.2 0.2 2.2 3 0 0 3 3 3 1 Sirohaem biosynthesis protein central Sirohm_synth_C PF14823.6 KOS20837.1 - 2.8e-11 42.9 0.4 1.7e-07 30.7 0.2 2.4 2 0 0 2 2 2 2 Sirohaem biosynthesis protein C-terminal Ferric_reduct PF01794.19 KOS20838.1 - 9.5e-23 80.7 9.6 3.3e-22 78.9 9.6 2.0 1 0 0 1 1 1 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 KOS20838.1 - 5.7e-20 72.0 0.0 8.2e-18 65.0 0.0 2.2 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 KOS20838.1 - 8.8e-10 38.6 0.2 9.5e-09 35.3 0.0 2.6 2 1 0 2 2 2 1 FAD-binding domain DUF1690 PF07956.11 KOS20839.1 - 1.8e-39 135.4 1.1 2e-39 135.2 1.1 1.0 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF853 PF05872.12 KOS20839.1 - 0.052 12.1 0.4 0.062 11.9 0.4 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) TYW3 PF02676.14 KOS20840.1 - 1.7e-71 240.0 0.0 2.1e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 PAPS_reduct PF01507.19 KOS20841.1 - 2.8e-42 144.7 0.0 3.5e-42 144.4 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family MR_MLE_C PF13378.6 KOS20842.1 - 4.1e-41 141.0 0.0 5.4e-41 140.6 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 KOS20842.1 - 3.7e-09 36.8 0.0 6.1e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Glyco_hydro_42 PF02449.15 KOS20842.1 - 0.12 11.7 0.0 0.39 10.0 0.0 1.7 2 0 0 2 2 2 0 Beta-galactosidase Serum_albumin PF00273.20 KOS20843.1 - 0.014 15.2 0.1 0.019 14.7 0.1 1.2 1 0 0 1 1 1 0 Serum albumin family LRR_4 PF12799.7 KOS20844.1 - 2.8e-10 40.3 8.4 1.8e-07 31.3 2.2 3.0 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS20844.1 - 1.4e-09 37.6 6.5 1.8e-09 37.2 5.1 1.9 2 0 0 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 KOS20844.1 - 0.051 14.1 8.6 2.1 9.2 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 KOS20844.1 - 0.21 11.7 3.9 2.7 8.3 0.2 2.9 2 0 0 2 2 2 0 Leucine Rich repeat Pectate_lyase_3 PF12708.7 KOS20845.1 - 4e-62 209.9 0.5 3.8e-49 167.4 0.0 2.4 2 0 0 2 2 2 2 Pectate lyase superfamily protein End_N_terminal PF12218.8 KOS20845.1 - 1.8e-06 27.5 1.2 0.037 13.7 0.1 2.9 2 0 0 2 2 2 2 N terminal extension of bacteriophage endosialidase PTR2 PF00854.21 KOS20846.1 - 2.7e-54 184.5 11.4 2.7e-54 184.5 11.4 1.6 2 0 0 2 2 2 1 POT family Glutaredoxin PF00462.24 KOS20847.1 - 6.6e-19 67.9 0.0 4.6e-18 65.2 0.0 2.1 2 0 0 2 2 2 1 Glutaredoxin Thioredoxin PF00085.20 KOS20847.1 - 1.3e-14 54.1 0.0 2.7e-14 53.0 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 KOS20847.1 - 0.016 15.6 0.0 1.8 8.9 0.0 2.6 2 1 1 3 3 3 0 Thioredoxin-like SH3_9 PF14604.6 KOS20848.1 - 3e-27 94.2 5.0 1.5e-14 53.6 0.4 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_1 PF00018.28 KOS20848.1 - 2.3e-26 91.1 3.9 1.9e-13 49.8 0.3 2.4 2 0 0 2 2 2 2 SH3 domain Cofilin_ADF PF00241.20 KOS20848.1 - 4.6e-15 55.5 0.0 9.8e-15 54.4 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_2 PF07653.17 KOS20848.1 - 4.4e-14 51.9 0.0 1.1e-05 25.0 0.0 2.7 2 0 0 2 2 2 2 Variant SH3 domain F-box-like PF12937.7 KOS20849.1 - 0.00017 21.4 0.0 0.00034 20.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS20849.1 - 0.0019 18.0 0.0 0.0045 16.8 0.0 1.6 1 0 0 1 1 1 1 F-box domain DUF1409 PF07197.12 KOS20849.1 - 0.15 12.0 0.1 0.28 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) Fungal_trans PF04082.18 KOS20850.1 - 6.1e-13 48.4 1.7 1.2e-12 47.5 1.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain eIF-3_zeta PF05091.12 KOS20851.1 - 2.1e-209 696.8 0.0 2.6e-209 696.6 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF569 PF04601.13 KOS20851.1 - 0.0051 16.5 0.1 0.017 14.8 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF569) NARG2_C PF10505.9 KOS20851.1 - 0.081 12.4 0.0 4.5 6.7 0.0 2.1 2 0 0 2 2 2 0 NMDA receptor-regulated gene protein 2 C-terminus DUF2076 PF09849.9 KOS20853.1 - 0.62 10.1 7.2 0.81 9.7 7.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CYSTM PF12734.7 KOS20853.1 - 4.3 7.7 57.5 0.054 13.8 40.4 3.5 1 1 1 2 2 2 0 Cysteine-rich TM module stress tolerance RXT2_N PF08595.11 KOS20854.1 - 0.016 15.2 10.3 0.047 13.7 3.0 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal SDA1 PF05285.12 KOS20854.1 - 0.029 13.8 6.5 0.046 13.2 6.5 1.2 1 0 0 1 1 1 0 SDA1 DUF4598 PF15370.6 KOS20854.1 - 0.086 13.3 6.1 1.4 9.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Cwf_Cwc_15 PF04889.12 KOS20854.1 - 0.12 12.1 18.8 0.33 10.7 0.8 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 KOS20854.1 - 0.13 11.9 9.8 1.5 8.5 0.3 2.3 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 KOS20854.1 - 0.34 10.2 7.2 0.69 9.2 7.2 1.4 1 0 0 1 1 1 0 BUD22 Pox_Ag35 PF03286.14 KOS20854.1 - 0.63 9.8 8.8 2.9 7.6 0.9 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 KOS20854.1 - 1.7 9.1 24.6 1.5 9.2 11.9 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sigma70_ner PF04546.13 KOS20854.1 - 7.3 6.4 12.3 11 5.9 0.3 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region GCIP PF13324.6 KOS20854.1 - 9.7 5.7 10.4 4.4 6.8 0.1 2.1 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting LIM PF00412.22 KOS20855.1 - 3.2e-25 88.1 23.9 8.3e-09 35.6 3.7 3.4 3 0 0 3 3 3 3 LIM domain Nudix_N_2 PF14803.6 KOS20855.1 - 0.097 12.6 14.2 3.5 7.6 1.2 5.2 4 0 0 4 4 4 0 Nudix N-terminal zf_C2H2_13 PF18508.1 KOS20855.1 - 0.098 12.3 4.2 4.8 6.8 0.1 3.4 3 0 0 3 3 3 0 Zinc finger domain Auto_anti-p27 PF06677.12 KOS20855.1 - 0.17 12.0 2.7 2.7 8.2 0.0 3.6 2 1 1 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-dskA_traR PF01258.17 KOS20855.1 - 3 7.9 26.1 0.69 9.9 0.9 5.2 4 1 1 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger CN_hydrolase PF00795.22 KOS20856.1 - 4.1e-41 141.0 0.1 4.9e-41 140.8 0.1 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase CP_ATPgrasp_2 PF14403.6 KOS20856.1 - 0.14 11.0 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Circularly permuted ATP-grasp type 2 NatB_MDM20 PF09797.9 KOS20857.1 - 1.4e-41 142.8 0.0 3.6e-41 141.4 0.0 1.7 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit Myb_DNA-binding PF00249.31 KOS20857.1 - 0.0018 18.4 0.5 2.1 8.6 0.0 3.3 3 0 0 3 3 3 2 Myb-like DNA-binding domain Prenyltrans PF00432.21 KOS20858.1 - 6.2e-35 118.6 5.9 3.7e-09 36.2 0.0 5.7 5 0 0 5 5 5 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 KOS20858.1 - 8.1e-05 21.9 0.2 0.012 14.7 0.0 2.6 1 1 2 3 3 3 3 Squalene-hopene cyclase C-terminal domain MTCP1 PF08991.10 KOS20858.1 - 0.016 15.4 4.4 0.017 15.4 2.1 2.1 2 0 0 2 2 2 0 Mature-T-Cell Proliferation I type SQHop_cyclase_N PF13249.6 KOS20858.1 - 0.02 14.0 0.9 28 3.7 0.1 3.9 2 1 1 4 4 4 0 Squalene-hopene cyclase N-terminal domain CHCH PF06747.13 KOS20858.1 - 0.42 10.8 4.7 0.9 9.8 4.7 1.6 1 0 0 1 1 1 0 CHCH domain Ilm1 PF10311.9 KOS20859.1 - 1.4e-61 207.0 0.2 1.6e-61 206.8 0.2 1.0 1 0 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 Pkinase PF00069.25 KOS20860.1 - 2.8e-64 217.0 0.0 4e-64 216.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20860.1 - 9.6e-38 129.9 0.0 1.4e-37 129.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS20860.1 - 7.1e-08 32.1 0.0 3.7e-07 29.7 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 KOS20860.1 - 0.00019 20.5 0.1 0.00019 20.5 0.1 2.2 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 KOS20860.1 - 0.0097 15.9 0.8 0.032 14.1 0.1 2.1 2 1 0 2 2 2 1 Phosphotransferase enzyme family Ferlin_C PF16165.5 KOS20860.1 - 0.056 13.4 1.5 0.13 12.2 1.5 1.5 1 0 0 1 1 1 0 Ferlin C-terminus Seadorna_VP7 PF07387.11 KOS20860.1 - 0.19 10.7 0.0 0.29 10.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 SNF2_N PF00176.23 KOS20861.1 - 1.1e-38 132.8 0.7 3.4e-18 65.5 0.1 2.3 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS20861.1 - 9.2e-19 67.8 0.0 5.6e-18 65.3 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 KOS20861.1 - 0.0066 15.7 0.2 1.1 8.3 0.0 2.6 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 HEPN_Swt1 PF18731.1 KOS20861.1 - 0.22 11.9 2.8 4.6 7.6 2.1 2.9 2 0 0 2 2 2 0 Swt1-like HEPN UQ_con PF00179.26 KOS20862.1 - 2.1e-47 160.3 0.0 2.4e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 KOS20862.1 - 0.0014 18.5 0.1 0.0026 17.6 0.1 1.5 1 1 0 1 1 1 1 UEV domain Prok-E2_B PF14461.6 KOS20862.1 - 0.0032 17.2 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 KOS20862.1 - 0.03 14.6 0.0 0.041 14.2 0.0 1.3 1 0 0 1 1 1 0 RWD domain Mt_ATP-synt_D PF05873.12 KOS20863.1 - 9.9e-21 74.2 1.7 1.2e-20 73.9 1.7 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) Dor1 PF04124.12 KOS20863.1 - 0.042 12.5 2.6 0.053 12.2 2.6 1.2 1 0 0 1 1 1 0 Dor1-like family T5orf172 PF10544.9 KOS20863.1 - 0.11 13.0 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 T5orf172 domain Laminin_II PF06009.12 KOS20863.1 - 0.33 11.0 4.6 4 7.4 0.1 2.6 2 1 0 2 2 2 0 Laminin Domain II TPR_MLP1_2 PF07926.12 KOS20863.1 - 0.55 10.3 8.3 1.3 9.1 0.5 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 KOS20863.1 - 1.5 9.4 6.0 3.1 8.3 0.3 2.3 1 1 2 3 3 3 0 Spectrin repeat NAC PF01849.18 KOS20864.1 - 1.1e-22 79.7 0.4 3.7e-22 78.0 0.0 2.0 2 1 0 2 2 2 1 NAC domain Myc_N PF01056.18 KOS20864.1 - 0.098 12.5 11.6 0.13 12.1 11.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PEX11 PF05648.14 KOS20864.1 - 0.13 11.7 1.4 0.15 11.5 0.5 1.5 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) CENP-B_dimeris PF09026.10 KOS20864.1 - 0.36 11.2 12.4 1.7 9.1 9.7 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 KOS20864.1 - 0.56 9.9 20.9 0.83 9.3 12.8 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Cytomega_UL84 PF06284.11 KOS20864.1 - 0.8 8.1 8.2 0.16 10.4 5.1 1.5 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein Peptidase_S64 PF08192.11 KOS20864.1 - 1.2 7.5 7.3 1.4 7.3 7.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 PGA2 PF07543.12 KOS20864.1 - 1.2 9.1 15.6 4.3 7.3 9.1 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 SpoIIIAH PF12685.7 KOS20864.1 - 3.5 7.4 16.2 0.62 9.9 10.0 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2052 PF09747.9 KOS20864.1 - 3.9 7.5 18.3 0.73 9.9 10.1 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Ribosomal_L14e PF01929.17 KOS20865.1 - 1.1e-27 96.3 3.1 1.6e-27 95.8 3.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 KOS20865.1 - 0.017 15.1 0.4 0.038 13.9 0.0 1.8 2 0 0 2 2 2 0 KOW motif DUF1687 PF07955.11 KOS20866.1 - 8.2e-29 100.7 0.0 1.1e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) L51_S25_CI-B8 PF05047.16 KOS20868.1 - 1.6e-13 50.3 0.0 2.1e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain MPC PF03650.13 KOS20869.1 - 2.6e-46 156.3 1.1 3.3e-46 156.0 1.1 1.1 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers MtN3_slv PF03083.16 KOS20869.1 - 0.1 12.6 0.4 0.15 12.1 0.4 1.3 1 0 0 1 1 1 0 Sugar efflux transporter for intercellular exchange CNH PF00780.22 KOS20870.1 - 1e-57 195.9 0.0 1.8e-57 195.1 0.0 1.3 1 0 0 1 1 1 1 CNH domain RhoGEF PF00621.20 KOS20870.1 - 1.3e-35 123.3 0.5 2.3e-35 122.5 0.5 1.4 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 KOS20870.1 - 1.7e-06 28.2 0.2 0.0001 22.4 0.2 3.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 KOS20870.1 - 0.0017 18.9 0.0 0.012 16.1 0.0 2.4 1 1 0 1 1 1 1 PH domain PH_16 PF17838.1 KOS20870.1 - 0.0022 17.8 0.0 0.31 10.9 0.0 2.4 2 0 0 2 2 2 2 PH domain Sod_Cu PF00080.20 KOS20871.1 - 3.1e-46 157.1 4.2 3.7e-46 156.8 4.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) NDUF_B8 PF05821.11 KOS20872.1 - 1.6e-08 34.7 4.5 2.6e-08 33.9 4.5 1.5 1 1 0 1 1 1 1 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) G-patch PF01585.23 KOS20873.1 - 7.8e-09 35.3 2.8 1.7e-08 34.2 2.8 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 KOS20873.1 - 3.4e-05 23.8 0.9 3.4e-05 23.8 0.9 2.3 2 0 0 2 2 2 1 G-patch domain RED_N PF07808.13 KOS20873.1 - 0.00042 20.0 3.2 0.0011 18.6 3.2 1.7 1 0 0 1 1 1 1 RED-like protein N-terminal region zf-RanBP PF00641.18 KOS20873.1 - 0.001 18.3 3.5 0.001 18.3 3.5 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 KOS20873.1 - 0.0092 15.8 0.1 0.23 11.3 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_2 PF12756.7 KOS20873.1 - 0.027 14.8 1.2 0.062 13.6 0.1 2.1 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) Vps36-NZF-N PF16988.5 KOS20873.1 - 0.029 13.8 1.6 0.12 11.8 0.3 2.3 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 KOS20873.1 - 0.13 12.3 0.9 0.28 11.3 0.3 1.8 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-C2H2_jaz PF12171.8 KOS20873.1 - 1 9.7 4.3 0.57 10.5 0.9 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding FAM220 PF15487.6 KOS20873.1 - 2.6 7.6 9.7 0.21 11.2 2.8 2.1 2 0 0 2 2 2 0 FAM220 family 4HBT_3 PF13622.6 KOS20874.1 - 1.1e-79 268.3 7.3 1.4e-79 267.9 7.3 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 KOS20874.1 - 2.3e-23 82.5 0.0 9.2e-11 41.7 0.0 4.1 3 1 0 3 3 3 3 Acyl-CoA thioesterase Roughex PF06020.11 KOS20874.1 - 0.14 11.2 2.6 0.22 10.6 2.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3682 PF12446.8 KOS20874.1 - 0.7 10.4 11.9 0.16 12.4 7.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Paf1 PF03985.13 KOS20874.1 - 1.4 7.8 6.2 2.2 7.2 6.2 1.2 1 0 0 1 1 1 0 Paf1 Transglycosylas PF06737.14 KOS20874.1 - 5.1 7.8 7.1 2.5 8.8 1.4 2.5 2 0 0 2 2 2 0 Transglycosylase-like domain ALO PF04030.14 KOS20875.1 - 2.8e-88 296.1 0.0 4e-88 295.6 0.0 1.2 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 KOS20875.1 - 2.2e-27 95.5 0.0 3.4e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain zf-C4H2 PF10146.9 KOS20876.1 - 0.61 10.4 5.3 0.27 11.5 0.4 2.2 2 0 0 2 2 2 0 Zinc finger-containing protein DUF2229 PF09989.9 KOS20876.1 - 3.7 7.1 6.2 1.8 8.2 0.4 2.5 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) CDC27 PF09507.10 KOS20877.1 - 3.3 7.0 15.3 0.01 15.3 5.7 1.7 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 adh_short PF00106.25 KOS20878.1 - 5.5e-38 130.4 0.1 6.5e-38 130.1 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS20878.1 - 1.6e-28 99.9 0.2 1.9e-28 99.6 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS20878.1 - 1e-12 48.4 0.2 1.4e-12 47.9 0.2 1.2 1 0 0 1 1 1 1 KR domain Stealth_CR3 PF17102.5 KOS20878.1 - 0.05 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Stealth protein CR3, conserved region 3 UPF0261 PF06792.11 KOS20878.1 - 0.083 11.8 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) CBFD_NFYB_HMF PF00808.23 KOS20879.1 - 2.7e-18 66.0 0.7 4e-18 65.4 0.3 1.5 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 KOS20879.1 - 0.00029 21.2 0.1 0.0012 19.3 0.0 1.9 1 1 1 2 2 2 1 Core histone H2A/H2B/H3/H4 Bromo_TP PF07524.13 KOS20879.1 - 0.013 15.5 0.0 0.038 14.0 0.0 1.8 1 1 1 2 2 2 0 Bromodomain associated S-methyl_trans PF02574.16 KOS20880.1 - 2.1e-53 181.8 0.0 2.4e-53 181.6 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase DAO PF01266.24 KOS20881.1 - 5.8e-44 151.1 9.1 6.7e-44 150.9 9.1 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOS20881.1 - 0.00098 19.6 0.0 2 9.0 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS20881.1 - 0.0013 18.9 0.1 0.0045 17.2 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain MCRA PF06100.11 KOS20881.1 - 0.0045 15.8 0.1 0.0063 15.4 0.1 1.1 1 0 0 1 1 1 1 MCRA family Pyr_redox_2 PF07992.14 KOS20881.1 - 0.065 12.5 0.0 1 8.5 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Romo1 PF10247.9 KOS20882.1 - 5.9e-27 93.8 17.4 7.5e-27 93.5 17.4 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 Tim17 PF02466.19 KOS20882.1 - 0.14 12.5 7.0 0.21 12.0 7.0 1.2 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Phage_holin_5_1 PF06946.11 KOS20882.1 - 0.39 11.1 2.5 0.53 10.7 2.5 1.2 1 0 0 1 1 1 0 Bacteriophage A118-like holin, Hol118 Bacteriocin_IIc PF10439.9 KOS20882.1 - 2.5 8.3 11.2 17 5.6 11.2 1.9 1 1 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide FHA PF00498.26 KOS20883.1 - 1.4e-16 60.6 0.1 4e-16 59.1 0.1 1.9 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 KOS20883.1 - 0.00011 22.4 0.0 0.0006 20.1 0.0 2.2 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain YhfZ_C PF14503.6 KOS20883.1 - 0.0024 17.5 0.1 0.0046 16.5 0.1 1.4 1 0 0 1 1 1 1 YhfZ C-terminal domain SIR2 PF02146.17 KOS20884.1 - 2.2e-53 180.8 0.0 3.7e-53 180.1 0.0 1.3 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 KOS20884.1 - 0.028 14.2 0.2 0.19 11.5 0.0 2.4 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain Cu-oxidase_3 PF07732.15 KOS20885.1 - 3.3e-44 149.7 2.0 1.5e-41 141.1 0.0 3.3 2 2 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 KOS20885.1 - 1.5e-36 125.9 0.0 2.2e-35 122.1 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 KOS20885.1 - 1.3e-32 112.4 8.2 7.8e-31 106.6 1.9 3.6 3 1 0 3 3 3 2 Multicopper oxidase ATP13 PF12921.7 KOS20886.1 - 4e-18 65.4 0.0 1.1e-17 63.9 0.0 1.7 2 0 0 2 2 2 1 Mitochondrial ATPase expression LSM PF01423.22 KOS20887.1 - 1.9e-13 49.9 0.2 2.1e-13 49.7 0.2 1.1 1 0 0 1 1 1 1 LSM domain COX16 PF14138.6 KOS20888.1 - 3.4e-32 110.8 0.1 4.5e-32 110.4 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 Oxidored_FMN PF00724.20 KOS20890.1 - 1e-72 245.3 0.0 1.2e-72 245.0 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Thioredoxin PF00085.20 KOS20891.1 - 3.8e-64 213.1 3.2 1.9e-30 104.9 0.1 4.6 5 0 0 5 5 5 3 Thioredoxin Thioredoxin_6 PF13848.6 KOS20891.1 - 9.9e-42 142.9 8.8 1.4e-34 119.6 1.3 3.6 3 1 1 4 4 4 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOS20891.1 - 8.5e-09 35.6 0.1 0.25 11.7 0.0 5.0 4 1 1 5 5 5 2 Thioredoxin-like Calsequestrin PF01216.17 KOS20891.1 - 4.4e-07 29.3 2.5 4.4e-07 29.3 2.5 1.5 2 0 0 2 2 2 1 Calsequestrin Thioredoxin_2 PF13098.6 KOS20891.1 - 1.1e-06 29.1 2.1 0.094 13.2 0.1 4.3 4 2 0 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 KOS20891.1 - 6.9e-06 25.6 0.0 0.0076 15.6 0.0 2.5 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family Thioredoxin_7 PF13899.6 KOS20891.1 - 1.3e-05 25.2 1.5 0.059 13.6 0.0 3.3 3 0 0 3 3 2 2 Thioredoxin-like Redoxin PF08534.10 KOS20891.1 - 5.3e-05 23.0 1.8 0.18 11.5 0.0 3.6 3 0 0 3 3 3 1 Redoxin AhpC-TSA PF00578.21 KOS20891.1 - 0.0005 20.0 0.9 0.71 9.8 0.1 3.2 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_3 PF13192.6 KOS20891.1 - 0.04 14.0 0.2 0.22 11.6 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin domain Thioredoxin_4 PF13462.6 KOS20891.1 - 2.3 8.4 6.0 22 5.1 0.1 3.5 2 2 0 2 2 2 0 Thioredoxin Ribosomal_60s PF00428.19 KOS20891.1 - 2.5 8.7 20.4 0.44 11.2 14.6 2.9 3 1 0 3 3 3 0 60s Acidic ribosomal protein Band_7 PF01145.25 KOS20891.1 - 3.1 7.8 6.6 3.6 7.6 0.0 2.5 2 1 0 2 2 2 0 SPFH domain / Band 7 family Rab_bind PF16704.5 KOS20892.1 - 0.097 12.7 0.3 0.37 10.8 0.3 1.8 1 1 0 1 1 1 0 Rab binding domain zf-HIT PF04438.16 KOS20893.1 - 2.2e-09 37.0 5.2 3.1e-09 36.5 5.2 1.2 1 0 0 1 1 1 1 HIT zinc finger Keratin_2_head PF16208.5 KOS20893.1 - 4.9 7.3 22.9 9.6 6.3 22.9 1.4 1 0 0 1 1 1 0 Keratin type II head tRNA-synt_2b PF00587.25 KOS20894.1 - 2e-32 112.6 0.0 1.3e-30 106.7 0.0 3.1 2 1 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOS20894.1 - 1.4e-17 63.6 0.1 2.7e-17 62.7 0.1 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 KOS20894.1 - 9.3e-13 48.1 0.0 2.1e-12 46.9 0.0 1.6 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 KOS20894.1 - 1.2e-10 41.3 0.0 3.5e-10 39.8 0.0 1.8 2 0 0 2 2 2 1 TGS domain WD40 PF00400.32 KOS20895.1 - 0.005 17.7 0.9 0.093 13.6 1.1 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF2415 PF10313.9 KOS20895.1 - 0.07 13.1 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Glyco_hydro_35 PF01301.19 KOS20896.1 - 1.1e-76 258.4 0.0 1.6e-76 258.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 BetaGal_dom4_5 PF13364.6 KOS20896.1 - 1.9e-46 157.3 0.3 1.4e-25 90.1 0.0 2.8 2 0 0 2 2 2 2 Beta-galactosidase jelly roll domain BetaGal_dom2 PF10435.9 KOS20896.1 - 2e-39 135.3 0.1 3.6e-39 134.5 0.1 1.4 1 0 0 1 1 1 1 Beta-galactosidase, domain 2 BetaGal_dom3 PF13363.6 KOS20896.1 - 1.6e-22 78.8 0.2 6.8e-22 76.8 0.0 2.1 2 0 0 2 2 2 1 Beta-galactosidase, domain 3 DLH PF01738.18 KOS20897.1 - 3.7e-09 36.5 0.0 5.5e-08 32.6 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Acetyltransf_9 PF13527.7 KOS20898.1 - 8e-06 26.0 0.0 1.4e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS20898.1 - 0.00026 20.9 0.0 0.00069 19.5 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS20898.1 - 0.00034 21.0 0.0 0.0008 19.8 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS20898.1 - 0.00068 19.6 0.0 0.06 13.3 0.0 2.5 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_1 PF00583.25 KOS20898.1 - 0.00071 19.8 0.0 0.018 15.2 0.0 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_13 PF13880.6 KOS20898.1 - 0.0046 16.9 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase FAR1 PF03101.15 KOS20900.1 - 0.00039 21.1 0.6 0.00039 21.1 0.6 2.0 2 0 0 2 2 2 1 FAR1 DNA-binding domain DUF3486 PF11985.8 KOS20900.1 - 0.087 13.2 5.3 0.45 10.9 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3486) Peptidase_A21 PF03566.13 KOS20900.1 - 0.12 10.6 4.9 0.17 10.1 4.9 1.1 1 0 0 1 1 1 0 Peptidase family A21 Rrn6 PF10214.9 KOS20900.1 - 1.4 7.3 11.8 1.6 7.2 11.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Presenilin PF01080.17 KOS20900.1 - 9.5 4.9 5.4 14 4.4 5.4 1.2 1 0 0 1 1 1 0 Presenilin MutS_V PF00488.21 KOS20901.1 - 2.5e-48 164.6 0.1 3.2e-48 164.3 0.1 1.1 1 0 0 1 1 1 1 MutS domain V NPR1_like_C PF12313.8 KOS20901.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal WBS_methylT PF12589.8 KOS20902.1 - 2.6e-14 53.7 3.2 4.8e-14 52.9 3.2 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 KOS20902.1 - 5.3e-12 46.2 0.0 9e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS20902.1 - 1.7e-10 41.5 0.0 4.1e-10 40.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS20902.1 - 7.9e-05 23.3 0.0 0.00025 21.7 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOS20902.1 - 0.00038 20.3 0.0 0.00074 19.3 0.0 1.5 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOS20902.1 - 0.0013 18.6 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS20902.1 - 0.0026 17.6 0.0 0.0043 16.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 KOS20902.1 - 0.011 15.1 0.0 0.093 12.0 0.0 2.0 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 KOS20902.1 - 0.048 13.0 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_32 PF13679.6 KOS20902.1 - 0.11 12.5 0.1 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain tRNA-synt_2 PF00152.20 KOS20903.1 - 2.8e-75 253.3 0.1 3.8e-75 252.9 0.1 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOS20903.1 - 1.1e-07 31.7 0.0 4.3e-07 29.8 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOS20903.1 - 1.6e-06 27.8 0.2 0.003 17.1 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) PBP PF01161.20 KOS20904.1 - 6.5e-14 52.4 0.0 8.6e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein FeoA PF04023.14 KOS20904.1 - 0.1 12.8 0.0 0.19 12.0 0.0 1.4 1 0 0 1 1 1 0 FeoA domain Aminotran_4 PF01063.19 KOS20905.1 - 1.3e-22 80.8 0.0 1.5e-22 80.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV IF-2B PF01008.17 KOS20906.1 - 2.8e-73 246.6 0.1 3.2e-73 246.4 0.1 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF2205 PF10224.9 KOS20907.1 - 5e-36 122.5 1.0 6.7e-36 122.1 1.0 1.2 1 0 0 1 1 1 1 Short coiled-coil protein AAA_32 PF13654.6 KOS20907.1 - 0.016 14.0 0.0 0.018 13.9 0.0 1.0 1 0 0 1 1 1 0 AAA domain p450 PF00067.22 KOS20908.1 - 1.9e-49 168.7 0.0 7.3e-48 163.5 0.0 2.1 1 1 0 1 1 1 1 Cytochrome P450 DHHA2 PF02833.14 KOS20909.1 - 3.3e-34 118.1 0.0 4.5e-34 117.7 0.0 1.2 1 0 0 1 1 1 1 DHHA2 domain DHH PF01368.20 KOS20909.1 - 3.8e-10 39.9 0.0 1.3e-09 38.2 0.0 1.7 2 0 0 2 2 2 1 DHH family RsfS PF02410.15 KOS20910.1 - 2.5e-12 47.1 0.0 7.3e-12 45.6 0.0 1.8 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation Nab1 PF04902.12 KOS20910.1 - 0.054 13.9 1.9 0.11 12.9 1.9 1.4 1 0 0 1 1 1 0 Conserved region in Nab1 RNA_pol PF00940.19 KOS20911.1 - 2.5e-183 609.6 0.0 3.8e-183 609.0 0.0 1.3 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 KOS20911.1 - 2e-90 303.6 1.4 3.6e-90 302.8 1.4 1.5 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal DUF806 PF05657.11 KOS20911.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF806) tRNA_bind PF01588.20 KOS20912.1 - 5.1e-22 77.8 0.1 1.3e-21 76.5 0.1 1.7 1 1 0 1 1 1 1 Putative tRNA binding domain GST_C_2 PF13410.6 KOS20912.1 - 5.6e-05 23.1 0.0 0.0001 22.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS20912.1 - 0.0052 17.0 0.3 0.019 15.2 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOS20912.1 - 0.076 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain DAP_epimerase PF01678.19 KOS20912.1 - 0.093 12.9 0.2 0.23 11.6 0.0 1.7 2 0 0 2 2 2 0 Diaminopimelate epimerase NUC153 PF08159.12 KOS20913.1 - 6.8e-14 51.4 0.6 6.8e-14 51.4 0.6 4.0 4 0 0 4 4 4 2 NUC153 domain RecT PF03837.14 KOS20913.1 - 0.082 12.4 0.2 0.082 12.4 0.2 2.8 3 0 0 3 3 3 0 RecT family DEAD PF00270.29 KOS20914.1 - 2.8e-46 157.5 0.0 5.8e-46 156.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS20914.1 - 3.4e-25 88.5 0.0 2.5e-24 85.7 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOS20914.1 - 8.5e-22 77.2 0.0 1.9e-21 76.0 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOS20914.1 - 4.2e-06 26.9 0.0 1e-05 25.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sad1_UNC PF07738.13 KOS20915.1 - 9.4e-10 38.6 0.1 0.00041 20.4 0.1 2.3 1 1 1 2 2 2 2 Sad1 / UNC-like C-terminal tRNA_synt_1c_R1 PF04558.15 KOS20915.1 - 0.01 15.9 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 GDP_Man_Dehyd PF16363.5 KOS20916.1 - 1.8e-47 162.4 0.0 3.2e-47 161.5 0.0 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 KOS20916.1 - 2.5e-47 161.4 0.0 3.1e-47 161.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOS20916.1 - 3.2e-15 55.9 0.0 5e-15 55.2 0.0 1.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 KOS20916.1 - 1.2e-13 50.8 0.0 3.9e-12 45.9 0.0 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 KOS20916.1 - 4.5e-12 45.7 0.0 6.6e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain adh_short PF00106.25 KOS20916.1 - 2.2e-09 37.1 0.0 3.4e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS20916.1 - 3e-06 27.2 0.0 4.9e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 KOS20916.1 - 1.6e-05 24.2 0.0 0.00018 20.7 0.0 2.2 1 1 0 1 1 1 1 Male sterility protein adh_short_C2 PF13561.6 KOS20916.1 - 0.00025 20.7 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_10 PF13460.6 KOS20916.1 - 0.00062 19.7 0.0 0.00095 19.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 KOS20916.1 - 0.0082 16.4 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 KOS20916.1 - 0.041 13.4 0.0 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 NmrA-like family UDPG_MGDP_dh_N PF03721.14 KOS20916.1 - 0.14 11.7 0.1 0.25 10.9 0.1 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain SNF2_N PF00176.23 KOS20917.1 - 4.6e-64 216.4 0.6 8.9e-64 215.4 0.6 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS20917.1 - 1.2e-20 73.9 0.0 9.8e-20 71.0 0.0 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS20917.1 - 5.7e-09 36.2 0.2 6.7e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 KOS20917.1 - 0.00047 19.4 0.2 0.0055 15.9 0.2 2.5 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 SWI2_SNF2 PF18766.1 KOS20917.1 - 0.0018 18.0 0.2 0.0086 15.8 0.0 2.2 2 1 0 2 2 2 1 SWI2/SNF2 ATPase ERCC3_RAD25_C PF16203.5 KOS20917.1 - 0.012 14.8 0.0 0.012 14.8 0.0 2.1 3 0 0 3 3 3 0 ERCC3/RAD25/XPB C-terminal helicase Spt5_N PF11942.8 KOS20917.1 - 4.5 8.3 17.2 7.7 7.6 4.5 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Phosphatase PF15698.5 KOS20918.1 - 0.034 13.3 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphatase SBDS PF01172.18 KOS20919.1 - 1.8e-23 82.4 0.0 2.1e-23 82.2 0.0 1.0 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein E1-E2_ATPase PF00122.20 KOS20920.1 - 4.4e-50 169.7 0.9 4.4e-50 169.7 0.9 2.8 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 KOS20920.1 - 6.7e-46 156.3 6.0 1.5e-45 155.2 6.0 1.6 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOS20920.1 - 4.5e-22 79.4 0.3 1.8e-21 77.4 0.3 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS20920.1 - 6.9e-19 67.7 0.0 1.5e-18 66.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 KOS20920.1 - 7.4e-19 67.2 0.0 2.2e-18 65.7 0.0 1.9 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS20920.1 - 4.5e-07 29.9 1.8 4.5e-06 26.6 1.1 2.4 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS20920.1 - 0.00019 21.9 0.0 0.00078 19.9 0.0 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase OPA3 PF07047.12 KOS20921.1 - 4.5e-45 152.5 3.2 4.5e-45 152.5 3.2 1.6 1 1 1 2 2 2 1 Optic atrophy 3 protein (OPA3) Vpu PF00558.19 KOS20921.1 - 0.065 13.0 0.5 0.15 11.9 0.5 1.6 1 0 0 1 1 1 0 Vpu protein DUF4140 PF13600.6 KOS20921.1 - 1.6 9.2 6.9 0.31 11.5 0.7 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 KOS20921.1 - 2.7 8.5 12.3 0.17 12.4 4.5 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DUF3464 PF11947.8 KOS20921.1 - 5 6.9 6.7 0.69 9.6 0.6 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Chitin_synth_2 PF03142.15 KOS20923.1 - 2.6e-287 953.6 0.0 3.4e-287 953.3 0.0 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS20923.1 - 1.4e-13 51.3 3.7 4.6e-13 49.5 3.7 2.0 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOS20923.1 - 1e-11 45.2 0.1 1.6e-08 34.7 0.0 2.6 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KOS20923.1 - 0.00021 20.8 0.0 0.0026 17.3 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOS20923.1 - 0.0021 17.9 0.0 0.092 12.6 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Pkinase PF00069.25 KOS20924.1 - 2e-68 230.6 0.0 3e-68 230.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS20924.1 - 1.3e-40 139.3 0.0 2.1e-40 138.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 KOS20924.1 - 1.4e-07 31.6 0.0 0.0002 21.5 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 KOS20924.1 - 1.2e-05 24.8 0.0 3.2e-05 23.4 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 KOS20924.1 - 0.0017 17.7 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOS20924.1 - 0.003 16.4 5.7 0.0092 14.8 0.1 2.2 2 0 0 2 2 2 1 Fungal protein kinase Ada3 PF10198.9 KOS20924.1 - 0.031 14.4 0.0 0.089 12.9 0.0 1.7 1 0 0 1 1 1 0 Histone acetyltransferases subunit 3 Haspin_kinase PF12330.8 KOS20924.1 - 0.14 11.0 0.0 0.24 10.3 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain VPR PF00522.18 KOS20924.1 - 0.6 10.2 2.4 2.2 8.4 0.5 2.9 3 1 0 3 3 3 0 VPR/VPX protein Myb_DNA-bind_6 PF13921.6 KOS20925.1 - 0.00074 19.7 0.1 0.0013 18.9 0.1 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain RXT2_N PF08595.11 KOS20925.1 - 0.0029 17.6 4.0 0.0099 15.9 0.2 2.4 2 0 0 2 2 2 1 RXT2-like, N-terminal FAM176 PF14851.6 KOS20925.1 - 0.29 10.8 4.3 0.93 9.1 0.4 2.3 2 0 0 2 2 2 0 FAM176 family BNIP2 PF12496.8 KOS20925.1 - 0.56 10.6 5.9 4 7.9 2.0 2.3 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Cwf_Cwc_15 PF04889.12 KOS20925.1 - 0.66 9.7 14.2 0.26 11.0 4.4 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 KOS20925.1 - 0.72 9.7 5.2 5.8 6.7 0.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region WRNPLPNID PF15017.6 KOS20925.1 - 0.88 10.5 8.4 6.4 7.7 0.6 2.4 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box CENP-B_dimeris PF09026.10 KOS20925.1 - 1.4 9.4 13.0 0.54 10.7 3.7 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3245 PF11595.8 KOS20925.1 - 1.6 9.2 11.9 0.67 10.4 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) PBP1_TM PF14812.6 KOS20925.1 - 3.3 8.2 15.1 0.56 10.6 5.3 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SRP-alpha_N PF04086.13 KOS20925.1 - 3.5 7.5 8.3 6.8 6.5 5.4 2.0 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal DTHCT PF08070.11 KOS20925.1 - 6.5 7.6 14.2 1.9 9.3 9.5 2.2 2 0 0 2 2 2 0 DTHCT (NUC029) region Sel1 PF08238.12 KOS20926.1 - 1.3e-40 136.9 25.5 2e-06 28.3 0.1 7.6 7 0 0 7 7 7 7 Sel1 repeat SOBP PF15279.6 KOS20926.1 - 0.0048 17.6 15.6 0.0048 17.6 15.6 3.9 2 1 2 4 4 4 1 Sine oculis-binding protein ANAPC3 PF12895.7 KOS20926.1 - 0.038 14.2 0.1 1.1 9.6 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 VMA21 PF09446.10 KOS20927.1 - 1.9e-14 53.5 9.7 3e-14 52.9 9.7 1.3 1 0 0 1 1 1 1 VMA21-like domain DUF4690 PF15756.5 KOS20927.1 - 0.062 13.9 0.1 2.7 8.7 0.1 2.1 2 0 0 2 2 2 0 Small Novel Rich in Cartilage GRP PF07172.11 KOS20927.1 - 0.22 12.3 0.7 0.31 11.8 0.1 1.6 2 0 0 2 2 2 0 Glycine rich protein family SNF2_N PF00176.23 KOS20928.1 - 1.1e-50 172.3 0.0 1.7e-50 171.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS20928.1 - 6.9e-15 55.3 0.0 1.4e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS20928.1 - 2.5e-06 27.6 0.0 8.5e-06 25.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HBS1_N PF08938.10 KOS20928.1 - 0.00038 20.7 4.3 0.0011 19.2 4.3 1.8 1 0 0 1 1 1 1 HBS1 N-terminus ERCC3_RAD25_C PF16203.5 KOS20928.1 - 0.0013 18.0 0.0 0.0027 17.0 0.0 1.5 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Pox_Ag35 PF03286.14 KOS20928.1 - 0.3 10.9 4.2 1.4 8.7 0.5 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 KOS20928.1 - 0.81 10.1 9.2 3.3 8.1 9.2 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 KOS20928.1 - 1.2 7.1 6.0 2.2 6.3 6.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi ILVD_EDD PF00920.21 KOS20930.1 - 1.3e-206 687.3 0.1 1.5e-206 687.1 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family PX PF00787.24 KOS20931.1 - 3.3e-19 68.9 0.1 6.9e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 PX domain Trypan_PARP PF05887.11 KOS20931.1 - 0.028 14.4 3.8 0.053 13.5 3.8 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SOG2 PF10428.9 KOS20931.1 - 1.4 8.0 11.1 2.2 7.4 11.1 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF1387 PF07139.11 KOS20931.1 - 3.4 7.3 6.2 5.6 6.6 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PAT1 PF09770.9 KOS20931.1 - 3.9 5.6 21.2 5.6 5.1 21.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Glyco_transf_15 PF01793.16 KOS20932.1 - 7.6e-98 327.7 4.3 2.9e-97 325.8 4.3 1.7 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF4604 PF15377.6 KOS20933.1 - 3.6e-27 95.9 17.9 4.4e-27 95.6 17.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) Ribosomal_L27A PF00828.19 KOS20934.1 - 3.7e-34 118.2 1.4 6e-34 117.5 1.4 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A ADH_zinc_N_2 PF13602.6 KOS20935.1 - 7.9e-15 56.1 0.0 1.5e-14 55.2 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOS20935.1 - 2.7e-09 37.1 0.0 4.9e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOS20935.1 - 2.2e-05 24.3 0.0 4.9e-05 23.2 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DapB_N PF01113.20 KOS20935.1 - 0.048 13.8 0.0 0.088 12.9 0.0 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus RmlD_sub_bind PF04321.17 KOS20935.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.21 KOS20935.1 - 0.14 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family NmrA PF05368.13 KOS20935.1 - 0.2 11.1 0.3 0.31 10.5 0.3 1.2 1 0 0 1 1 1 0 NmrA-like family DUF4449 PF14613.6 KOS20936.1 - 0.0056 16.8 0.1 0.031 14.4 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4449) DUF2423 PF10338.9 KOS20936.1 - 0.03 14.6 1.4 1 9.6 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2423) COX5B PF01215.19 KOS20938.1 - 1.2e-56 189.9 0.1 1.7e-56 189.4 0.1 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb 4HBT_3 PF13622.6 KOS20939.1 - 1.7e-17 64.5 2.5 2.5e-17 64.0 2.5 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DEAD PF00270.29 KOS20941.1 - 2.8e-37 128.2 0.0 5.4e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS20941.1 - 9e-31 106.5 0.0 3.2e-30 104.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS20941.1 - 7.3e-05 22.8 0.1 0.00054 20.0 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CDC45 PF02724.14 KOS20941.1 - 8.5e-05 21.0 0.6 0.00017 20.1 0.6 1.4 1 0 0 1 1 1 1 CDC45-like protein FAM110_C PF14160.6 KOS20941.1 - 0.026 15.6 0.4 1.9 9.6 0.0 2.5 2 0 0 2 2 2 0 Centrosome-associated C terminus CSD2 PF17876.1 KOS20941.1 - 0.19 11.9 1.2 0.76 10.0 0.1 2.3 2 0 0 2 2 2 0 Cold shock domain DUF5092 PF17010.5 KOS20941.1 - 1.4 8.8 4.0 0.4 10.6 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5092) DUF913 PF06025.12 KOS20941.1 - 3.7 6.4 6.0 0.27 10.2 0.5 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Glyco_hydro_3_C PF01915.22 KOS20943.1 - 1.3e-43 149.4 0.0 1.8e-43 148.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS20943.1 - 9.1e-32 110.7 0.0 1.4e-31 110.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS20943.1 - 1.2e-07 31.7 0.0 4.3e-07 30.0 0.0 1.9 1 1 1 2 2 2 1 Fibronectin type III-like domain ERAP1_C PF11838.8 KOS20944.1 - 3.5e-85 286.3 0.8 1.2e-84 284.5 0.1 2.1 2 1 1 3 3 3 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KOS20944.1 - 5.4e-83 277.9 1.0 8.5e-83 277.2 1.0 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KOS20944.1 - 3.8e-48 164.1 0.1 1e-47 162.7 0.0 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain Sugar_tr PF00083.24 KOS20945.1 - 4.9e-126 421.2 24.4 5.5e-126 421.1 24.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS20945.1 - 9.1e-25 87.3 64.0 2.1e-22 79.5 31.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Isochorismatase PF00857.20 KOS20946.1 - 5.6e-13 49.4 0.0 7.6e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 Isochorismatase family Fungal_trans PF04082.18 KOS20947.1 - 9e-13 47.9 5.2 1.5e-12 47.2 0.3 2.2 2 0 0 2 2 2 2 Fungal specific transcription factor domain Pec_lyase_C PF00544.19 KOS20948.1 - 1.2e-15 57.7 5.3 1.5e-13 50.8 5.3 2.8 1 1 0 1 1 1 1 Pectate lyase Beta_helix PF13229.6 KOS20948.1 - 0.00011 22.1 8.6 0.00035 20.5 7.5 2.2 1 1 1 2 2 2 1 Right handed beta helix region Glyco_hydro_65N PF03636.15 KOS20950.1 - 4.6e-31 108.2 0.0 8.6e-31 107.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65m PF03632.15 KOS20950.1 - 1.9e-24 86.2 2.4 1.5e-18 66.9 0.2 2.3 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Methyltransf_16 PF10294.9 KOS20951.1 - 2.1e-14 53.7 0.0 2.7e-14 53.3 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase PCMT PF01135.19 KOS20951.1 - 0.001 18.8 0.0 0.0018 18.0 0.0 1.4 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 KOS20951.1 - 0.0045 17.7 0.0 0.0075 17.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS20951.1 - 0.0045 16.8 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 KOS20951.1 - 0.022 14.3 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 KOS20951.1 - 0.03 13.7 0.0 0.04 13.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KOS20951.1 - 0.058 14.1 0.0 0.094 13.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain FtsJ PF01728.19 KOS20951.1 - 0.19 11.8 0.0 0.29 11.2 0.0 1.4 1 1 0 1 1 1 0 FtsJ-like methyltransferase Dynamin_M PF01031.20 KOS20952.1 - 1.5e-109 365.6 0.0 2.5e-109 364.9 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 KOS20952.1 - 5.8e-56 189.2 0.0 1.1e-55 188.2 0.0 1.5 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 KOS20952.1 - 4.8e-30 103.6 1.8 1.7e-29 101.8 1.2 2.2 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOS20952.1 - 3.6e-05 23.8 0.3 0.00059 19.9 0.3 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase Alk_phosphatase PF00245.20 KOS20954.1 - 2.1e-103 346.5 0.0 2.6e-103 346.2 0.0 1.1 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 KOS20954.1 - 8.1e-05 22.1 0.1 0.0002 20.8 0.1 1.6 1 0 0 1 1 1 1 Metalloenzyme superfamily Ricin_B_lectin PF00652.22 KOS20955.1 - 4.9e-16 59.1 0.1 1.9e-05 24.9 0.0 4.1 2 2 2 4 4 4 4 Ricin-type beta-trefoil lectin domain RicinB_lectin_2 PF14200.6 KOS20955.1 - 1.6e-06 28.7 0.1 0.21 12.4 0.0 3.6 3 1 0 3 3 3 2 Ricin-type beta-trefoil lectin domain-like GBP_PSP PF02425.15 KOS20955.1 - 0.12 12.1 0.6 16 5.3 0.1 2.8 2 0 0 2 2 2 0 Paralytic/GBP/PSP peptide DNA_ligase_A_M PF01068.21 KOS20956.1 - 7.6e-45 153.1 0.0 1.5e-44 152.1 0.0 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 KOS20956.1 - 1.5e-42 145.9 0.0 2.7e-42 145.0 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 KOS20956.1 - 1.5e-18 67.7 0.0 8e-18 65.3 0.0 2.2 3 0 0 3 3 3 1 RNA ligase DNA_ligase_A_C PF04679.15 KOS20956.1 - 8.1e-14 52.0 0.4 3.3e-13 50.1 0.0 2.2 2 0 0 2 2 2 1 ATP dependent DNA ligase C terminal region BRCT_2 PF16589.5 KOS20956.1 - 5.1e-12 46.0 0.0 2.3e-07 31.1 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 KOS20956.1 - 3.3e-08 33.8 0.0 2.9e-06 27.5 0.0 2.6 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 KOS20956.1 - 0.0014 18.7 0.0 0.0035 17.4 0.0 1.7 1 0 0 1 1 1 1 DNA ligase IV LIG3_BRCT PF16759.5 KOS20956.1 - 0.012 15.8 0.0 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain PTCB-BRCT PF12738.7 KOS20956.1 - 0.031 14.2 0.0 0.5 10.3 0.0 2.4 2 0 0 2 2 2 0 twin BRCT domain Phage_min_cap2 PF06152.11 KOS20956.1 - 0.11 11.4 0.0 0.23 10.3 0.0 1.4 1 0 0 1 1 1 0 Phage minor capsid protein 2 UPRTase PF14681.6 KOS20957.1 - 1.8e-73 246.4 0.0 2e-73 246.2 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 KOS20957.1 - 3e-06 26.8 0.5 1e-05 25.1 0.5 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain NAD_binding_10 PF13460.6 KOS20957.1 - 0.032 14.1 0.1 0.069 13.0 0.0 1.6 2 0 0 2 2 2 0 NAD(P)H-binding P5CR_dimer PF14748.6 KOS20957.1 - 0.063 13.5 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation TMP-TENI PF02581.17 KOS20957.1 - 0.1 11.9 0.7 2.7 7.3 0.3 2.2 2 0 0 2 2 2 0 Thiamine monophosphate synthase CorA PF01544.18 KOS20958.1 - 4.4e-25 88.6 3.9 9.4e-20 71.1 1.6 2.7 2 1 0 2 2 2 2 CorA-like Mg2+ transporter protein Myb_DNA-binding PF00249.31 KOS20960.1 - 9.8e-13 48.1 3.1 5e-09 36.2 0.3 2.2 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS20960.1 - 9.3e-07 29.0 0.6 0.00077 19.7 0.1 2.5 1 1 1 2 2 2 2 Myb-like DNA-binding domain Ndc1_Nup PF09531.10 KOS20960.1 - 2.7 6.6 17.5 3.8 6.1 17.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Myb_DNA-binding PF00249.31 KOS20961.1 - 0.0045 17.2 0.5 0.077 13.2 0.1 2.3 2 0 0 2 2 2 1 Myb-like DNA-binding domain SGP PF17228.2 KOS20961.1 - 0.35 11.7 7.1 1.1 10.2 6.6 2.2 1 1 0 1 1 1 0 Sulphur globule protein DUF4766 PF15973.5 KOS20961.1 - 0.36 11.4 14.7 0.077 13.6 10.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4766) Sporozoite_P67 PF05642.11 KOS20961.1 - 0.98 7.4 10.8 1.4 6.9 10.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Mucin PF01456.17 KOS20961.1 - 1.5 8.8 35.2 0.25 11.3 31.1 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein FSA_C PF10479.9 KOS20961.1 - 4.4 5.3 14.6 6.2 4.8 14.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SecE PF00584.20 KOS20962.1 - 5.2e-15 55.1 0.0 5.8e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex NAD_binding_10 PF13460.6 KOS20963.1 - 1.6e-16 60.7 0.0 3e-16 59.9 0.0 1.3 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 KOS20963.1 - 0.055 13.0 0.0 0.093 12.3 0.0 1.4 1 0 0 1 1 1 0 NmrA-like family Glyco_hydro_16 PF00722.21 KOS20964.1 - 8.8e-49 165.4 1.3 1.3e-48 164.8 1.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Chitin_bind_1 PF00187.19 KOS20964.1 - 0.12 12.8 12.2 0.35 11.4 12.2 1.7 1 0 0 1 1 1 0 Chitin recognition protein SQS_PSY PF00494.19 KOS20965.1 - 2e-56 191.4 0.0 3.2e-56 190.7 0.0 1.3 1 1 0 1 1 1 1 Squalene/phytoene synthase DUF3558 PF12079.8 KOS20965.1 - 0.018 15.0 0.3 0.031 14.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) SNF2_N PF00176.23 KOS20966.1 - 1.2e-71 241.3 0.0 1.7e-71 240.8 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 KOS20966.1 - 1.3e-25 89.1 0.0 2.5e-25 88.2 0.0 1.5 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 KOS20966.1 - 1.6e-13 50.9 0.0 4.3e-13 49.6 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 KOS20966.1 - 1.4e-05 24.8 5.1 3e-05 23.7 5.1 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS20966.1 - 4.1e-05 23.4 8.4 4.1e-05 23.4 8.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBA_4 PF14555.6 KOS20966.1 - 0.00056 19.7 0.1 0.1 12.4 0.0 2.6 2 0 0 2 2 2 1 UBA-like domain zf-C3HC4 PF00097.25 KOS20966.1 - 0.00067 19.5 9.2 0.0014 18.5 9.2 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS20966.1 - 0.0021 18.0 5.5 0.0046 17.0 5.5 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 KOS20966.1 - 0.012 16.0 10.0 0.012 16.0 10.0 1.9 2 0 0 2 2 2 0 Ring finger domain zf-UBP_var PF17807.1 KOS20966.1 - 1.5 8.6 6.6 4.5 7.1 2.6 2.5 2 0 0 2 2 2 0 Variant UBP zinc finger zf-C3HC4_4 PF15227.6 KOS20966.1 - 4.3 7.6 7.2 8.9 6.6 7.2 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING DUF2057 PF09829.9 KOS20966.1 - 4.6 7.4 10.7 14 5.8 10.7 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) zf-RING_5 PF14634.6 KOS20966.1 - 7.6 6.6 15.2 0.2 11.6 8.3 2.1 2 1 0 2 2 2 0 zinc-RING finger domain Dynamin_N PF00350.23 KOS20967.1 - 5.6e-19 68.8 0.1 1.3e-18 67.7 0.1 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOS20967.1 - 5.7e-11 42.5 0.1 8.9e-10 38.7 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS20967.1 - 8.1e-06 25.5 2.6 7.4e-05 22.4 1.0 2.6 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS20967.1 - 0.0081 16.1 0.4 2.9 7.8 0.1 2.8 2 1 1 3 3 3 1 RsgA GTPase PMEI PF04043.15 KOS20967.1 - 0.011 16.1 0.1 0.036 14.4 0.1 1.8 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor cobW PF02492.19 KOS20967.1 - 0.022 14.4 0.4 0.43 10.1 0.5 2.7 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 KOS20967.1 - 0.032 14.4 0.1 1.1 9.5 0.0 2.6 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FlgN PF05130.12 KOS20967.1 - 0.037 14.5 2.7 0.16 12.5 0.4 2.4 2 0 0 2 2 2 0 FlgN protein FH2 PF02181.23 KOS20967.1 - 0.041 13.0 0.2 0.091 11.9 0.2 1.5 1 0 0 1 1 1 0 Formin Homology 2 Domain IIGP PF05049.13 KOS20967.1 - 0.075 12.1 0.0 0.17 10.9 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) TsaE PF02367.17 KOS20967.1 - 0.088 12.8 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 KOS20967.1 - 0.092 12.4 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_29 PF13555.6 KOS20967.1 - 0.11 12.2 0.0 0.3 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 KOS20967.1 - 0.12 12.9 0.0 0.3 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Rpp20 PF12328.8 KOS20968.1 - 5.4e-26 91.2 0.0 6.7e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 KOS20968.1 - 1.4e-12 47.2 0.0 2.3e-12 46.5 0.0 1.4 1 1 0 1 1 1 1 Alba Rogdi_lz PF10259.9 KOS20969.1 - 1.7e-82 276.9 0.0 2e-82 276.7 0.0 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein CAP PF00188.26 KOS20970.1 - 4e-20 72.9 3.1 6.1e-20 72.3 3.1 1.3 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF3237 PF11578.8 KOS20971.1 - 2.2e-24 86.0 0.0 2.6e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3237) Nup54 PF13874.6 KOS20972.1 - 5.9e-38 130.1 0.6 5.9e-38 130.1 0.6 2.1 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nup54_57_C PF18570.1 KOS20972.1 - 3.1e-09 36.2 2.2 3.1e-09 36.2 2.2 2.5 3 0 0 3 3 3 1 NUP57/Nup54 C-terminal domain Nucleoporin_FG PF13634.6 KOS20972.1 - 0.0099 16.7 9.2 0.018 15.9 9.2 1.4 1 0 0 1 1 1 1 Nucleoporin FG repeat region YliH PF10799.8 KOS20972.1 - 0.046 13.6 0.3 0.18 11.8 0.1 2.0 1 1 1 2 2 2 0 Biofilm formation protein (YliH/bssR) UPF0184 PF03670.13 KOS20972.1 - 0.11 12.9 0.7 0.41 11.1 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) AAA_23 PF13476.6 KOS20972.1 - 0.14 12.6 1.6 2.9 8.3 1.6 2.3 1 1 0 1 1 1 0 AAA domain DUF4407 PF14362.6 KOS20972.1 - 0.54 9.6 4.3 1.2 8.4 4.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0449 PF15136.6 KOS20972.1 - 9.3 6.8 10.5 2.8 8.4 1.8 3.0 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 CHCH PF06747.13 KOS20973.1 - 1.1e-08 35.0 10.6 4.5e-06 26.6 4.7 2.4 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 KOS20973.1 - 0.00031 20.7 8.1 0.15 12.1 0.3 2.2 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 KOS20973.1 - 0.0034 17.4 10.4 0.37 10.8 3.8 2.2 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 KOS20973.1 - 0.21 11.9 7.9 3.6 8.0 1.3 2.8 2 1 1 3 3 3 0 Cytochrome c oxidase assembly protein PET191 NDUF_B7 PF05676.13 KOS20973.1 - 0.51 10.1 7.9 19 5.1 5.9 2.3 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) COX6B PF02297.17 KOS20973.1 - 1.2 9.4 11.5 3.5 7.9 0.9 2.2 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb LIAS_N PF16881.5 KOS20974.1 - 8.6e-15 55.1 0.0 1.7e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 KOS20974.1 - 1.5e-13 51.5 0.0 2.5e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily GDC-P PF02347.16 KOS20975.1 - 4e-159 530.1 0.0 3.2e-147 490.8 0.0 2.4 2 1 0 2 2 2 2 Glycine cleavage system P-protein Aminotran_5 PF00266.19 KOS20975.1 - 6.4e-08 31.9 0.0 4.6e-05 22.6 0.0 2.5 2 1 1 3 3 3 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOS20975.1 - 0.00013 21.3 0.0 0.00028 20.3 0.0 1.5 1 0 0 1 1 1 1 Beta-eliminating lyase NIPSNAP PF07978.13 KOS20976.1 - 9.3e-41 138.2 0.3 1.4e-30 105.6 0.2 2.1 2 0 0 2 2 2 2 NIPSNAP FSH1 PF03959.13 KOS20977.1 - 1.6e-53 181.5 0.0 2e-53 181.2 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KOS20977.1 - 0.12 12.2 0.2 32 4.2 0.5 3.3 3 1 0 3 3 3 0 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 KOS20977.1 - 0.16 11.2 0.2 1.6 7.9 0.0 2.4 1 1 1 3 3 3 0 Serine aminopeptidase, S33 DUF5313 PF17240.2 KOS20978.1 - 1.3 9.5 4.5 1.6 9.1 3.9 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5313) DUF929 PF06053.11 KOS20978.1 - 1.5 8.1 5.1 2.4 7.4 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF929) SAM_2 PF07647.17 KOS20979.1 - 9.4e-15 54.5 0.0 1.9e-14 53.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 KOS20979.1 - 1.7e-13 50.8 0.0 3.1e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RA PF00788.23 KOS20979.1 - 1.1e-11 45.2 0.0 2e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_4 PF18017.1 KOS20979.1 - 0.04 13.9 0.1 0.074 13.0 0.1 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Aminotran_1_2 PF00155.21 KOS20980.1 - 4.6e-58 197.1 0.0 6.1e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II AMP-binding PF00501.28 KOS20981.1 - 6.3e-42 143.6 0.0 1e-41 142.9 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme ACAS_N PF16177.5 KOS20981.1 - 4.1e-09 36.2 1.6 2.7e-08 33.6 0.1 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus AMP-binding_C PF13193.6 KOS20981.1 - 0.0031 18.5 0.0 0.0074 17.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PIG-L PF02585.17 KOS20982.1 - 7.7e-22 78.3 1.3 7.7e-22 78.3 1.3 2.3 2 1 0 2 2 2 1 GlcNAc-PI de-N-acetylase RskA PF10099.9 KOS20982.1 - 2.2 8.5 10.2 0.97 9.7 0.2 2.7 2 1 0 2 2 2 0 Anti-sigma-K factor rskA LapA_dom PF06305.11 KOS20982.1 - 3.5 7.5 5.8 6.6 6.6 4.4 2.0 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Macoilin PF09726.9 KOS20984.1 - 0.034 12.7 11.6 0.047 12.3 11.6 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 KOS20984.1 - 0.11 11.2 6.6 0.15 10.8 6.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 KOS20984.1 - 0.31 10.2 1.4 0.42 9.8 1.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GCD14 PF08704.10 KOS20984.1 - 1.3 8.7 4.9 2.5 7.7 4.9 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit LMBR1 PF04791.16 KOS20984.1 - 4.3 6.1 6.9 5.7 5.7 6.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF498 PF04430.14 KOS20985.1 - 9.9e-28 96.4 0.0 1.3e-27 96.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF498/DUF598) Nha1_C PF08619.10 KOS20986.1 - 2.8e-115 386.2 26.1 6.1e-115 385.1 26.1 1.5 1 1 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus Na_H_Exchanger PF00999.21 KOS20986.1 - 1.7e-75 254.2 25.5 2e-75 254.0 25.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FlgD_ig PF13860.6 KOS20986.1 - 0.028 14.3 0.0 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 FlgD Ig-like domain Colicin_E5 PF12106.8 KOS20986.1 - 0.046 14.0 0.0 0.28 11.5 0.0 2.2 2 0 0 2 2 2 0 Colicin E5 ribonuclease domain YrhC PF14143.6 KOS20986.1 - 0.13 12.4 5.2 0.12 12.5 0.9 2.7 2 0 0 2 2 2 0 YrhC-like protein DUF4419 PF14388.6 KOS20987.1 - 0.19 11.1 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4419) Lyase_1 PF00206.20 KOS20988.1 - 6.1e-06 25.9 0.0 6.2e-06 25.8 0.0 1.0 1 0 0 1 1 1 1 Lyase Lyase_1 PF00206.20 KOS20989.1 - 4.5e-69 233.2 0.0 6.5e-69 232.7 0.0 1.2 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 KOS20989.1 - 4.5e-22 78.2 0.1 9.1e-22 77.2 0.1 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus WD40 PF00400.32 KOS20990.1 - 5e-13 49.3 2.9 0.18 12.7 0.1 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40 PF00400.32 KOS20991.1 - 4.1e-41 138.2 26.9 2.4e-09 37.7 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS20991.1 - 5.1e-09 36.3 0.4 0.11 12.8 0.0 4.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS20991.1 - 0.0004 19.2 4.8 0.017 13.8 0.2 3.4 2 1 1 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOS20991.1 - 0.0082 15.1 0.0 9.4 5.1 0.0 3.8 2 2 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOS20991.1 - 0.0083 15.5 0.0 0.46 9.7 0.0 2.1 2 0 0 2 2 2 1 WD40-like domain PD40 PF07676.12 KOS20991.1 - 0.025 14.5 1.8 22 5.1 0.0 4.7 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Ribosomal_L18 PF17135.4 KOS20992.1 - 1.3e-91 305.1 3.4 1.5e-91 304.9 3.4 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 KOS20992.1 - 0.0018 18.9 0.8 0.0018 18.9 0.8 2.4 2 1 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Dimerisation PF08100.11 KOS20992.1 - 0.14 12.2 0.1 6.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Dimerisation domain 6PGD PF00393.19 KOS20994.1 - 9.3e-95 317.3 1.1 1.1e-85 287.6 0.2 2.1 1 1 1 2 2 2 2 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 KOS20994.1 - 2.2e-48 164.4 0.0 3.2e-48 163.9 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ANT PF03374.14 KOS20994.1 - 0.0045 17.3 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 Phage antirepressor protein KilAC domain Shikimate_DH PF01488.20 KOS20994.1 - 0.062 13.4 0.3 0.26 11.4 0.1 2.0 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase GP67 PF17634.2 KOS20994.1 - 0.093 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 Gene product 67 NAD_binding_11 PF14833.6 KOS20994.1 - 0.18 12.1 1.7 0.19 12.0 0.0 2.0 3 0 0 3 3 3 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase HPP PF04982.13 KOS20996.1 - 6.2e-39 133.0 11.0 6.2e-39 133.0 11.0 2.1 2 0 0 2 2 2 1 HPP family SSP160 PF06933.11 KOS20996.1 - 2.9 6.0 9.2 4 5.5 9.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 KOS20996.1 - 3.1 5.8 5.2 4.2 5.4 5.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Ribosomal_L19e PF01280.20 KOS20997.1 - 1.5e-61 206.7 6.7 1.5e-61 206.7 6.7 1.8 1 1 1 2 2 2 1 Ribosomal protein L19e SHMT PF00464.19 KOS20998.1 - 3.3e-134 447.4 0.0 3.9e-134 447.2 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase DegT_DnrJ_EryC1 PF01041.17 KOS20998.1 - 0.0047 16.3 0.0 0.0072 15.7 0.0 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Ribosomal_S6 PF01250.17 KOS20999.1 - 1.3e-17 63.9 0.0 1.6e-17 63.5 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 DUF1934 PF09148.10 KOS20999.1 - 0.18 11.8 0.0 0.32 11.0 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1934) Cullin_binding PF03556.15 KOS21000.1 - 4.1e-32 111.2 4.9 4.6e-32 111.0 4.9 1.0 1 0 0 1 1 1 1 Cullin binding PTCB-BRCT PF12738.7 KOS21001.1 - 2.8e-41 139.3 1.5 1.7e-17 63.1 0.2 4.3 4 0 0 4 4 4 4 twin BRCT domain BRCT PF00533.26 KOS21001.1 - 4.6e-32 110.2 0.0 3e-10 40.3 0.0 4.3 4 0 0 4 4 4 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 KOS21001.1 - 1.9e-10 41.0 0.0 0.0046 17.3 0.0 4.2 4 0 0 4 4 4 3 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 KOS21001.1 - 7.8e-05 22.9 0.5 0.56 10.5 0.0 3.4 3 0 0 3 3 3 2 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 KOS21001.1 - 0.003 17.4 0.0 0.034 14.0 0.0 2.7 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 KOS21001.1 - 0.13 12.3 0.0 3.5 7.8 0.0 2.9 3 0 0 3 3 3 0 BRCA1 C Terminus (BRCT) domain FUSC PF04632.12 KOS21002.1 - 0.14 10.7 2.5 0.16 10.5 2.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Chs7 PF12271.8 KOS21003.1 - 2e-102 342.5 17.6 1.1e-99 333.5 13.0 2.0 1 1 1 2 2 2 2 Chitin synthase export chaperone DUF3382 PF11862.8 KOS21003.1 - 0.029 14.6 0.8 0.029 14.6 0.8 2.2 2 1 0 3 3 3 0 Domain of unknown function (DUF3382) DUF4281 PF14108.6 KOS21003.1 - 0.45 10.9 9.9 0.09 13.1 5.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4281) AAA PF00004.29 KOS21004.1 - 1.4e-10 41.7 0.2 2e-09 38.0 0.2 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOS21004.1 - 1.7e-05 24.9 0.0 0.00044 20.2 0.0 2.3 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 KOS21004.1 - 6.8e-05 23.3 0.1 0.00027 21.4 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 KOS21004.1 - 0.0011 19.3 0.7 0.0038 17.5 0.2 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 KOS21004.1 - 0.0021 18.6 0.0 0.018 15.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 KOS21004.1 - 0.0026 17.8 0.0 0.0048 16.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE TIP49 PF06068.13 KOS21004.1 - 0.0042 16.3 0.0 0.0066 15.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 KOS21004.1 - 0.034 14.2 0.0 0.079 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOS21004.1 - 0.039 13.7 0.0 0.088 12.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 KOS21004.1 - 0.058 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 KOS21004.1 - 0.071 13.3 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOS21004.1 - 0.082 12.4 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 KOS21004.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.6 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 KOS21004.1 - 0.13 11.3 0.0 0.24 10.4 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 KOS21004.1 - 0.14 12.5 0.0 0.47 10.9 0.0 1.9 2 0 0 2 2 1 0 RNA helicase AAA_6 PF12774.7 KOS21004.1 - 0.2 10.6 0.0 0.31 9.9 0.0 1.2 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region NTPase_1 PF03266.15 KOS21004.1 - 0.23 11.4 0.1 0.72 9.7 0.0 1.8 2 0 0 2 2 2 0 NTPase Utp8 PF10395.9 KOS21005.1 - 3.8e-06 25.7 0.0 6.9e-06 24.9 0.0 1.5 2 0 0 2 2 2 1 Utp8 family DUF2759 PF10958.8 KOS21006.1 - 0.021 14.6 0.3 0.034 13.9 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2759) Pirin PF02678.16 KOS21007.1 - 8.9e-26 90.0 1.5 2.2e-25 88.7 1.5 1.6 1 1 0 1 1 1 1 Pirin Cupin_2 PF07883.11 KOS21007.1 - 0.0023 17.6 1.9 0.059 13.1 0.3 3.0 2 1 0 2 2 2 1 Cupin domain MTBP_C PF14920.6 KOS21007.1 - 0.031 14.0 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 MDM2-binding MoaE PF02391.17 KOS21008.1 - 2.6e-36 124.3 0.1 3.1e-36 124.1 0.1 1.1 1 0 0 1 1 1 1 MoaE protein Lipase_GDSL_lke PF16255.5 KOS21008.1 - 0.046 13.1 0.0 0.061 12.7 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Pheromone PF08015.11 KOS21009.1 - 0.057 14.5 1.1 2.7 9.1 0.1 2.3 2 0 0 2 2 2 0 Fungal mating-type pheromone DUF3446 PF11928.8 KOS21009.1 - 0.082 13.2 6.7 1.3 9.4 0.8 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain Oxysterol_BP PF01237.18 KOS21010.1 - 1.7e-132 441.8 0.0 6.7e-132 439.8 0.0 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein Ank_2 PF12796.7 KOS21010.1 - 1.8e-17 63.7 3.9 1.6e-08 35.0 0.2 2.9 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS21010.1 - 4.2e-14 52.7 0.2 3.9e-08 33.7 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS21010.1 - 5.1e-14 52.1 0.5 1.8e-08 34.5 0.2 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) PH PF00169.29 KOS21010.1 - 1.1e-12 48.4 0.7 2e-12 47.6 0.7 1.5 1 0 0 1 1 1 1 PH domain Ank_3 PF13606.6 KOS21010.1 - 7.7e-12 44.3 0.7 0.00026 21.2 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 KOS21010.1 - 2.4e-11 43.5 2.5 0.00069 20.0 0.3 3.7 3 0 0 3 3 3 2 Ankyrin repeat PH_8 PF15409.6 KOS21010.1 - 8.7e-08 32.3 0.7 2e-07 31.2 0.7 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOS21010.1 - 1.8e-05 25.1 1.0 4.3e-05 23.9 1.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain AP_endonuc_2 PF01261.24 KOS21011.1 - 2.8e-34 118.4 1.4 3.4e-34 118.2 0.5 1.6 2 0 0 2 2 2 1 Xylose isomerase-like TIM barrel Pkinase PF00069.25 KOS21012.1 - 1.3e-12 47.7 0.0 1.8e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21012.1 - 3.2e-05 23.4 0.0 4.4e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase zf-H2C2_2 PF13465.6 KOS21013.1 - 2.7e-11 43.4 17.0 1.1e-05 25.7 2.0 3.4 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 KOS21013.1 - 3.6e-09 36.6 23.2 0.0016 18.7 8.0 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS21013.1 - 9.3e-07 29.2 18.5 0.016 16.0 6.3 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_9 PF16293.5 KOS21013.1 - 0.0023 17.7 3.9 2 8.3 0.3 3.3 2 1 1 3 3 3 1 C2H2 type zinc-finger (1 copy) Rad50_zn_hook PF04423.14 KOS21013.1 - 0.0029 17.4 1.9 0.17 11.8 0.3 2.4 2 0 0 2 2 2 1 Rad50 zinc hook motif zf-C2H2_6 PF13912.6 KOS21013.1 - 0.022 14.8 16.7 0.071 13.1 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 KOS21013.1 - 0.023 14.8 3.9 0.25 11.5 1.3 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 KOS21013.1 - 0.025 14.9 10.5 0.063 13.6 5.7 2.3 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding GATA PF00320.27 KOS21013.1 - 0.026 14.1 1.4 0.091 12.4 1.4 1.9 1 1 0 1 1 1 0 GATA zinc finger zf-CHCC PF10276.9 KOS21013.1 - 0.032 14.3 2.4 1.9 8.6 0.4 2.9 2 0 0 2 2 2 0 Zinc-finger domain bZIP_1 PF00170.21 KOS21013.1 - 0.099 12.8 0.1 0.099 12.8 0.1 1.7 2 0 0 2 2 1 0 bZIP transcription factor zf-C2HC_2 PF13913.6 KOS21013.1 - 0.14 12.1 5.9 0.1 12.5 0.5 2.3 2 0 0 2 2 2 0 zinc-finger of a C2HC-type DZR PF12773.7 KOS21013.1 - 0.25 11.4 6.2 2.5 8.2 6.4 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_jaz PF12171.8 KOS21013.1 - 0.34 11.2 11.2 0.76 10.1 3.8 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_9 PF14369.6 KOS21013.1 - 0.38 11.0 5.6 17 5.8 0.1 3.2 2 1 1 3 3 3 0 zinc-ribbon Prok-RING_1 PF14446.6 KOS21013.1 - 0.72 9.8 3.4 21 5.1 0.1 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zinc-ribbons_6 PF07191.12 KOS21013.1 - 0.88 9.6 4.7 5.3 7.1 4.7 2.2 1 1 0 1 1 1 0 zinc-ribbons zf-XS PF03470.14 KOS21013.1 - 1.5 9.2 6.7 14 6.1 1.1 2.8 2 0 0 2 2 2 0 XS zinc finger domain Zn_Tnp_IS1595 PF12760.7 KOS21013.1 - 1.8 8.6 7.7 2.9 8.0 2.9 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-UDP PF14569.6 KOS21013.1 - 2.4 8.3 6.8 6.2 7.0 0.2 2.7 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-C2H2_2 PF12756.7 KOS21013.1 - 2.6 8.4 11.0 0.48 10.8 1.7 3.0 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 KOS21013.1 - 5.4 6.9 7.0 2.5 7.9 0.6 2.8 1 1 2 3 3 3 0 GAGA factor zf-C2HE PF16278.5 KOS21013.1 - 6.6 7.3 18.1 2 8.9 1.1 3.2 2 1 2 4 4 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-FPG_IleRS PF06827.14 KOS21013.1 - 7.4 6.5 8.3 18 5.3 0.2 3.0 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS zf-met PF12874.7 KOS21013.1 - 8.7 6.9 13.7 6.4 7.3 0.4 3.3 3 1 0 3 3 3 0 Zinc-finger of C2H2 type DAGAT PF03982.13 KOS21014.1 - 2.5e-91 305.7 0.0 3.3e-91 305.3 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase KH_8 PF17903.1 KOS21015.1 - 2.2e-06 27.6 0.0 4.3e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 KOS21015.1 - 0.012 15.4 0.5 0.029 14.2 0.5 1.6 1 0 0 1 1 1 0 KH domain MDM31_MDM32 PF08118.11 KOS21016.1 - 1.1e-245 816.3 0.0 1.2e-245 816.1 0.0 1.0 1 0 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3825 PF12873.7 KOS21016.1 - 0.036 13.5 0.4 9.4 5.6 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF3825) Mad3_BUB1_I PF08311.12 KOS21017.1 - 3.2e-43 146.7 0.3 4.6e-43 146.1 0.3 1.2 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 KOS21017.1 - 0.036 14.2 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein OmpH PF03938.14 KOS21017.1 - 0.075 13.4 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Enolase_C PF00113.22 KOS21018.1 - 6.5e-151 501.6 0.0 8.3e-151 501.3 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 KOS21018.1 - 2.6e-56 189.4 0.2 4.5e-56 188.6 0.2 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 KOS21018.1 - 7.2e-05 22.4 0.0 0.00012 21.7 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 KOS21018.1 - 0.015 14.5 0.1 0.061 12.5 0.1 1.9 2 0 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus Hist_deacetyl PF00850.19 KOS21019.1 - 1e-78 264.9 0.0 1.4e-78 264.5 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Noelin-1 PF12308.8 KOS21019.1 - 0.16 11.9 0.2 0.28 11.2 0.2 1.3 1 0 0 1 1 1 0 Neurogenesis glycoprotein SUN PF03856.13 KOS21020.1 - 2.6e-90 302.1 11.4 3.3e-90 301.8 11.4 1.1 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) Myosin_head PF00063.21 KOS21022.1 - 1.2e-264 879.7 0.0 2.5e-264 878.6 0.0 1.6 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_tail_1 PF01576.19 KOS21022.1 - 2e-11 42.6 259.6 2e-09 35.9 172.1 6.6 1 1 1 2 2 2 2 Myosin tail Myosin_N PF02736.19 KOS21022.1 - 3.9e-11 42.6 0.5 8.9e-11 41.5 0.5 1.7 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain Halo_GVPC PF05465.13 KOS21022.1 - 0.052 13.8 3.6 0.33 11.2 0.6 3.3 2 0 0 2 2 2 0 Halobacterial gas vesicle protein C (GVPC) repeat AAA_22 PF13401.6 KOS21022.1 - 0.071 13.4 0.0 0.071 13.4 0.0 5.6 4 0 0 4 4 4 0 AAA domain Rota_NSP4 PF01452.16 KOS21022.1 - 0.85 9.3 3.6 5.1 6.7 3.6 2.4 1 0 0 1 1 1 0 Rotavirus non structural protein zf-PARP PF00645.18 KOS21023.1 - 1e-20 74.4 0.3 1e-20 74.4 0.3 2.1 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region PC4 PF02229.16 KOS21023.1 - 0.095 12.3 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Transcriptional Coactivator p15 (PC4) Peptidase_C12 PF01088.21 KOS21024.1 - 4e-51 173.7 0.0 4.9e-51 173.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Pet191_N PF10203.9 KOS21025.1 - 4.1e-27 94.3 4.1 5.7e-27 93.8 4.1 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 PAN_3 PF08277.12 KOS21025.1 - 0.056 13.3 0.5 0.096 12.5 0.5 1.4 1 0 0 1 1 1 0 PAN-like domain COBRA PF04833.15 KOS21025.1 - 0.078 12.9 0.3 0.11 12.3 0.3 1.2 1 0 0 1 1 1 0 COBRA-like protein NDUF_B7 PF05676.13 KOS21025.1 - 0.097 12.4 1.6 1.6 8.5 0.0 2.4 1 1 1 2 2 2 0 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) CX9C PF16860.5 KOS21025.1 - 0.45 10.6 7.7 0.67 10.0 1.1 3.0 2 1 1 3 3 3 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Metallophos PF00149.28 KOS21026.1 - 3.1e-10 40.9 0.0 3.1e-10 40.9 0.0 1.8 3 0 0 3 3 3 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOS21026.1 - 5.3e-07 30.0 0.0 1.6e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Macoilin PF09726.9 KOS21026.1 - 0.22 10.1 22.4 0.37 9.3 22.4 1.4 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 KOS21026.1 - 6.6 4.7 35.2 9.1 4.2 35.2 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Abhydrolase_1 PF00561.20 KOS21028.1 - 2.2e-24 86.5 0.0 2.2e-23 83.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 KOS21028.1 - 8.4e-22 76.5 0.0 1.8e-21 75.5 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 KOS21028.1 - 0.00025 20.4 0.0 0.0069 15.7 0.0 2.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 FSH1 PF03959.13 KOS21028.1 - 0.00063 19.5 0.0 1.1 8.9 0.0 2.4 2 0 0 2 2 2 2 Serine hydrolase (FSH1) DUF4148 PF13663.6 KOS21028.1 - 0.0054 16.9 0.8 0.015 15.5 0.8 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4148) DUF2749 PF10907.8 KOS21028.1 - 0.55 10.4 2.4 1.3 9.3 2.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) TAL_FSA PF00923.19 KOS21029.1 - 1.5e-96 323.1 0.4 1.8e-96 322.9 0.4 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase C5-epim_C PF06662.13 KOS21029.1 - 0.079 12.5 0.2 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus DUF3887 PF13026.6 KOS21029.1 - 0.88 10.4 3.2 3.1 8.7 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF3887) SNase PF00565.17 KOS21030.1 - 3.7e-66 220.4 0.8 1.9e-19 70.2 0.0 5.8 6 0 0 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 KOS21030.1 - 3.3e-23 82.0 0.0 5.9e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Tudor domain SMN PF06003.12 KOS21030.1 - 3.7e-05 23.1 0.0 7.4e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) Snf7 PF03357.21 KOS21031.1 - 6.2e-35 120.3 18.7 6.2e-35 120.3 18.7 1.5 2 0 0 2 2 2 1 Snf7 RHH_8 PF17723.1 KOS21031.1 - 0.091 12.9 3.9 0.2 11.8 0.1 2.6 1 1 2 3 3 3 0 Ribbon-Helix-Helix transcriptional regulator family Ist1 PF03398.14 KOS21031.1 - 0.19 11.7 7.2 0.29 11.1 7.2 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway PspA_IM30 PF04012.12 KOS21031.1 - 0.57 9.7 15.4 1.2 8.6 4.9 2.2 1 1 1 2 2 2 0 PspA/IM30 family DSBA PF01323.20 KOS21031.1 - 1.4 8.6 6.0 4.6 7.0 6.0 1.8 1 1 0 1 1 1 0 DSBA-like thioredoxin domain PP2C PF00481.21 KOS21032.1 - 1.5e-62 211.6 0.1 2.2e-49 168.4 0.0 3.3 1 1 0 2 2 2 2 Protein phosphatase 2C DUF1842 PF08896.10 KOS21032.1 - 0.065 13.5 0.1 6.1 7.2 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1842) TolA PF06519.11 KOS21032.1 - 0.1 12.8 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 TolA C-terminal Zn_clus PF00172.18 KOS21033.1 - 6.7e-08 32.5 15.1 1.3e-07 31.6 15.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 KOS21033.1 - 0.0091 14.6 0.3 0.011 14.3 0.3 1.1 1 0 0 1 1 1 1 Macoilin family Apt1 PF10351.9 KOS21033.1 - 0.49 9.2 3.8 0.71 8.7 3.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain HSP20 PF00011.21 KOS21034.1 - 5.7e-16 58.5 0.2 2e-11 43.9 0.2 2.5 1 1 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 KOS21034.1 - 0.00068 19.2 0.2 0.0064 16.0 0.2 2.1 1 1 0 1 1 1 1 HSP20-like domain found in ArsA Ribosomal_60s PF00428.19 KOS21034.1 - 0.064 13.9 7.9 0.078 13.6 5.8 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein Cytomega_UL84 PF06284.11 KOS21034.1 - 0.35 9.3 1.5 0.41 9.0 1.5 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein LDB19 PF13002.7 KOS21035.1 - 1.3e-33 116.4 0.2 2e-33 115.7 0.2 1.2 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 KOS21035.1 - 1.6e-05 25.0 1.0 0.00062 19.8 0.1 2.9 3 1 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain SUIM_assoc PF16619.5 KOS21036.1 - 0.0024 17.9 5.6 0.0086 16.1 5.6 1.8 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Ribosomal_L5_C PF00673.21 KOS21037.1 - 1.7e-22 79.4 0.0 2.4e-22 78.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 KOS21037.1 - 2.7e-20 72.4 0.0 8.2e-20 70.9 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L5 DnaJ PF00226.31 KOS21038.1 - 2e-16 59.8 0.5 3.6e-16 59.0 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain DUF456 PF04306.13 KOS21038.1 - 0.011 16.0 4.9 0.017 15.4 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF456) Clr5 PF14420.6 KOS21039.1 - 7.4e-20 70.9 3.2 1.9e-19 69.6 3.2 1.7 1 0 0 1 1 1 1 Clr5 domain TPR_21 PF09976.9 KOS21039.1 - 0.052 13.3 0.8 0.084 12.6 0.8 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain DUF2852 PF11014.8 KOS21039.1 - 0.11 12.6 0.8 0.3 11.3 0.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) PITH PF06201.13 KOS21040.1 - 5.1e-22 78.7 0.0 1.6e-10 41.4 0.1 2.4 1 1 1 2 2 2 2 PITH domain Thioredoxin PF00085.20 KOS21040.1 - 1.9e-10 40.6 0.0 3.8e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin HyaE PF07449.11 KOS21040.1 - 0.006 16.5 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE OST3_OST6 PF04756.13 KOS21040.1 - 0.027 13.8 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family DUF1582 PF07621.11 KOS21041.1 - 0.2 11.6 3.6 0.44 10.5 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1582) Macoilin PF09726.9 KOS21041.1 - 4.9 5.6 11.4 6.4 5.2 11.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF1700 PF08006.11 KOS21042.1 - 1 8.9 7.1 1.2 8.6 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) AC_N PF16214.5 KOS21042.1 - 1.5 7.9 8.5 1.5 7.8 8.5 1.0 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Vac7 PF12751.7 KOS21042.1 - 3.1 7.1 3.7 3.3 7.0 3.7 1.0 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 RhoGAP PF00620.27 KOS21043.1 - 3.4e-44 150.3 0.5 8.3e-44 149.1 0.3 1.7 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 KOS21043.1 - 1e-12 48.5 0.0 2.6e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 KOS21043.1 - 0.00012 22.4 0.0 0.00024 21.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 KOS21043.1 - 0.11 12.8 0.0 0.37 11.1 0.0 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain PX PF00787.24 KOS21043.1 - 0.16 12.0 0.0 0.45 10.5 0.0 1.8 2 0 0 2 2 2 0 PX domain WD40 PF00400.32 KOS21044.1 - 1.1e-36 124.1 18.7 3e-07 31.0 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21044.1 - 2.1e-14 53.6 0.0 0.00038 20.7 0.1 4.5 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS21044.1 - 2.9e-05 23.2 0.1 0.25 10.3 0.0 3.8 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 KOS21044.1 - 0.00036 20.5 0.0 0.28 11.1 0.0 2.6 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 KOS21044.1 - 0.0064 15.9 0.0 0.83 8.9 0.0 3.1 2 1 1 3 3 3 1 WD40-like domain p450 PF00067.22 KOS21045.1 - 1.1e-42 146.4 0.0 1.3e-42 146.2 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Bax1-I PF01027.20 KOS21046.1 - 1.3e-51 175.4 28.8 1.5e-51 175.2 28.8 1.0 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 Septin PF00735.18 KOS21047.1 - 1.8e-106 355.5 0.0 3.1e-106 354.8 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOS21047.1 - 7.9e-05 22.7 0.0 0.0002 21.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS21047.1 - 0.0011 18.9 0.1 0.0042 17.0 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KOS21047.1 - 0.0058 16.7 2.9 3 7.9 0.0 3.1 2 1 1 3 3 3 2 Dynamin family GTP_EFTU PF00009.27 KOS21047.1 - 0.03 13.9 0.2 0.14 11.7 0.1 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 KOS21047.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 KOS21047.1 - 0.14 11.5 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family IIGP PF05049.13 KOS21047.1 - 0.14 11.2 0.0 0.26 10.3 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Ribosomal_S17e PF00833.18 KOS21047.1 - 0.27 11.2 2.7 0.71 9.8 2.7 1.7 1 0 0 1 1 1 0 Ribosomal S17 AAA_22 PF13401.6 KOS21047.1 - 0.42 10.9 1.7 0.49 10.7 0.1 2.0 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 KOS21048.1 - 0.00014 22.6 0.0 0.03 15.2 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21048.1 - 0.0066 16.7 0.0 0.099 13.0 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 KOS21049.1 - 2.9e-16 59.0 0.0 6e-15 54.8 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS21049.1 - 0.00068 19.7 0.0 0.0014 18.7 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif Cu_amine_oxid PF01179.20 KOS21050.1 - 5.1e-139 463.7 0.0 6e-139 463.5 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN3 PF02728.16 KOS21050.1 - 0.00041 20.7 0.0 0.001 19.4 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N3 domain Baculo_p74 PF04583.12 KOS21050.1 - 0.24 10.9 0.0 0.38 10.2 0.0 1.2 1 0 0 1 1 1 0 Baculoviridae p74 conserved region Gly_transf_sug PF04488.15 KOS21051.1 - 1.6e-14 54.3 0.0 3.8e-14 53.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif AMP-binding PF00501.28 KOS21052.1 - 2.4e-87 293.3 0.0 3e-87 293.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS21052.1 - 1.2e-17 64.6 0.2 4.1e-17 62.9 0.2 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain EccE PF11203.8 KOS21052.1 - 0.023 15.0 0.8 2.4 8.5 0.1 3.0 2 0 0 2 2 2 0 Putative type VII ESX secretion system translocon, EccE TRAM_LAG1_CLN8 PF03798.16 KOS21053.1 - 8e-47 159.5 19.7 8e-47 159.5 19.7 1.8 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KOS21053.1 - 9.6e-20 70.0 0.2 9.6e-20 70.0 0.2 2.5 2 0 0 2 2 2 1 TRAM1-like protein MtN3_slv PF03083.16 KOS21053.1 - 0.016 15.2 4.0 0.046 13.8 0.7 2.9 3 0 0 3 3 3 0 Sugar efflux transporter for intercellular exchange RDD PF06271.12 KOS21053.1 - 1.3 9.2 6.4 0.49 10.6 0.1 2.9 3 0 0 3 3 3 0 RDD family DLIC PF05783.11 KOS21054.1 - 6.5e-05 22.0 0.5 0.028 13.2 0.1 2.1 1 1 0 2 2 2 2 Dynein light intermediate chain (DLIC) Thioredox_DsbH PF03190.15 KOS21055.1 - 4.7e-55 186.0 0.0 7.8e-55 185.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Glyco_hydro_76 PF03663.14 KOS21055.1 - 0.00054 19.6 1.2 0.0021 17.6 0.3 1.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 DUF4799 PF16056.5 KOS21055.1 - 0.32 10.1 2.3 0.27 10.3 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4799) SUI1 PF01253.22 KOS21056.1 - 1.5e-23 83.1 0.6 1.5e-23 83.1 0.6 1.8 2 0 0 2 2 2 1 Translation initiation factor SUI1 Img2 PF05046.14 KOS21056.1 - 0.025 14.8 0.1 0.056 13.7 0.0 1.7 2 1 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) TnpV PF14198.6 KOS21056.1 - 0.099 12.6 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV MscS_TM PF12794.7 KOS21056.1 - 0.16 10.8 1.7 0.22 10.4 1.7 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 RNA_polI_A14 PF08203.11 KOS21056.1 - 0.62 10.8 2.7 2.4 8.9 0.8 2.2 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 VWA_2 PF13519.6 KOS21057.1 - 1.8e-25 89.6 0.0 4.4e-25 88.4 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 KOS21057.1 - 7e-10 39.4 0.2 9.2e-10 39.0 0.2 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 KOS21057.1 - 2.6e-06 27.4 0.0 3.7e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Ssl1-like UIM PF02809.20 KOS21057.1 - 0.019 14.8 1.0 0.056 13.4 1.0 1.8 1 0 0 1 1 1 0 Ubiquitin interaction motif Band_7 PF01145.25 KOS21058.1 - 1.9e-22 80.1 3.2 3e-22 79.5 3.2 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Methyltransf_11 PF08241.12 KOS21059.1 - 8.5e-15 55.2 0.0 2.4e-14 53.8 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS21059.1 - 3.5e-07 30.8 0.0 1e-06 29.3 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS21059.1 - 0.014 16.2 0.0 0.051 14.3 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KOS21059.1 - 0.05 13.4 0.0 0.18 11.6 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain WIYLD PF10440.9 KOS21059.1 - 0.15 11.9 0.0 0.45 10.3 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin-binding WIYLD domain Elongin_A PF06881.11 KOS21060.1 - 2.7e-27 95.3 0.0 9e-27 93.7 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A ubiquitin PF00240.23 KOS21061.1 - 1.8e-14 53.2 0.8 2e-14 53.1 0.8 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 KOS21061.1 - 6.3e-07 29.1 0.3 6.7e-07 29.1 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 KOS21061.1 - 0.00055 20.3 0.1 0.00055 20.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain HAD PF12710.7 KOS21062.1 - 2.2e-09 38.0 5.8 7.7e-09 36.2 5.8 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS21062.1 - 0.028 14.7 0.1 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 KOS21062.1 - 0.16 12.1 0.0 17 5.4 0.0 2.2 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase TFIIF_beta_N PF17683.1 KOS21063.1 - 9.2e-30 104.1 0.0 1.9e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 KOS21063.1 - 1.2e-28 99.0 0.1 2e-28 98.3 0.1 1.4 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 KOS21063.1 - 0.0023 18.8 0.2 0.0052 17.6 0.1 1.8 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TPT PF03151.16 KOS21064.1 - 7e-19 68.3 19.4 9.9e-19 67.8 16.3 2.3 2 0 0 2 2 2 1 Triose-phosphate Transporter family PUNUT PF16913.5 KOS21064.1 - 0.00065 19.0 16.8 0.00065 19.0 16.8 2.2 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport SARAF PF06682.12 KOS21064.1 - 0.0059 16.3 2.0 0.048 13.3 1.3 2.7 2 1 1 3 3 3 1 SOCE-associated regulatory factor of calcium homoeostasis GWT1 PF06423.12 KOS21064.1 - 0.0074 16.4 1.4 5.1 7.2 0.0 3.0 3 0 0 3 3 3 2 GWT1 EamA PF00892.20 KOS21064.1 - 0.012 15.7 41.8 0.068 13.3 17.9 3.6 3 1 0 3 3 3 0 EamA-like transporter family DUF2956 PF11169.8 KOS21064.1 - 0.014 15.5 1.4 0.19 12.0 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) UAA PF08449.11 KOS21064.1 - 0.037 13.2 21.0 0.0075 15.5 16.9 1.9 2 0 0 2 2 2 0 UAA transporter family Ctr PF04145.15 KOS21064.1 - 0.044 14.4 1.0 7.6 7.1 0.0 3.7 4 0 0 4 4 4 0 Ctr copper transporter family TMEM51 PF15345.6 KOS21064.1 - 0.079 12.8 0.1 0.079 12.8 0.1 2.4 2 0 0 2 2 2 0 Transmembrane protein 51 SID-1_RNA_chan PF13965.6 KOS21064.1 - 0.087 11.2 0.0 0.087 11.2 0.0 2.5 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 DAG1 PF05454.11 KOS21064.1 - 0.13 11.6 3.0 0.26 10.6 3.0 1.4 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF2615 PF11027.8 KOS21064.1 - 1.1 9.5 0.0 1.1 9.5 0.0 3.9 5 0 0 5 5 3 0 Protein of unknown function (DUF2615) EphA2_TM PF14575.6 KOS21064.1 - 2.7 8.9 16.2 1 10.3 0.1 4.4 4 1 1 5 5 3 0 Ephrin type-A receptor 2 transmembrane domain FAM176 PF14851.6 KOS21064.1 - 2.8 7.6 12.4 3 7.5 0.7 3.6 3 1 0 3 3 3 0 FAM176 family TMEM89 PF15098.6 KOS21064.1 - 6.9 6.8 5.9 1.1 9.4 0.6 2.4 3 0 0 3 3 3 0 TMEM89 protein family PHM7_cyt PF14703.6 KOS21065.1 - 0.12 12.6 0.3 0.14 12.3 0.3 1.1 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Erv26 PF04148.13 KOS21066.1 - 3.9e-92 307.7 0.4 4.6e-92 307.5 0.4 1.1 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 Cytochrom_C_asm PF01578.20 KOS21066.1 - 0.94 9.2 7.4 0.076 12.8 2.3 1.7 2 1 0 2 2 2 0 Cytochrome C assembly protein Peptidase_M20 PF01546.28 KOS21067.1 - 2e-31 109.3 0.0 1e-30 107.0 0.0 2.0 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOS21067.1 - 2.4e-08 33.9 0.1 6.7e-08 32.4 0.0 1.8 2 0 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KOS21067.1 - 0.0027 17.4 0.0 0.0096 15.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 DUF4294 PF14127.6 KOS21067.1 - 0.02 14.8 0.0 2.9 7.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4294) HEAT_2 PF13646.6 KOS21067.1 - 0.065 13.6 0.3 0.31 11.4 0.0 2.2 2 0 0 2 2 2 0 HEAT repeats GTP_EFTU PF00009.27 KOS21068.1 - 6.5e-19 68.2 0.0 1.1e-18 67.5 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 KOS21068.1 - 1.2e-09 38.4 1.8 3.7e-09 36.8 0.8 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 KOS21068.1 - 3.8e-05 23.9 0.0 0.0001 22.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 KOS21068.1 - 0.00045 20.3 0.2 0.0012 18.9 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS21068.1 - 0.0013 18.7 0.3 0.94 9.4 0.1 2.4 2 0 0 2 2 2 2 RsgA GTPase Roc PF08477.13 KOS21068.1 - 0.013 15.7 0.1 0.098 12.9 0.0 2.3 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Dynamin_N PF00350.23 KOS21068.1 - 0.031 14.3 0.0 0.079 13.0 0.0 1.7 1 0 0 1 1 1 0 Dynamin family PduV-EutP PF10662.9 KOS21068.1 - 0.032 14.0 0.2 3.5 7.4 0.1 2.9 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation F-box PF00646.33 KOS21069.1 - 2.1e-09 37.0 0.3 5.6e-09 35.7 0.3 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS21069.1 - 1.1e-07 31.6 2.4 2.2e-07 30.7 0.2 2.5 2 0 0 2 2 2 1 F-box-like V-ATPase_C PF03223.15 KOS21071.1 - 2.9e-118 395.5 0.0 3.3e-118 395.3 0.0 1.0 1 0 0 1 1 1 1 V-ATPase subunit C mRNA_cap_C PF03919.15 KOS21071.1 - 0.012 16.3 0.4 0.03 14.9 0.1 1.9 2 1 0 2 2 2 0 mRNA capping enzyme, C-terminal domain Baculo_PEP_C PF04513.12 KOS21071.1 - 0.18 11.8 1.6 11 6.1 0.2 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Rad60-SLD PF11976.8 KOS21072.1 - 6.8e-21 73.9 0.1 7.9e-21 73.7 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 KOS21072.1 - 2.3e-11 43.3 0.0 2.6e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family Nup84_Nup100 PF04121.13 KOS21073.1 - 4e-176 587.3 0.0 4.6e-176 587.1 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 Mod_r PF07200.13 KOS21074.1 - 4.6e-29 101.4 0.1 5.4e-29 101.2 0.1 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein 4HBT PF03061.22 KOS21076.1 - 2.1e-10 40.8 0.0 4.2e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 Thioesterase superfamily CBF PF03914.17 KOS21077.1 - 1.5e-50 171.6 3.5 4.5e-50 170.0 0.1 2.8 2 0 0 2 2 2 1 CBF/Mak21 family CNOT1_TTP_bind PF16417.5 KOS21077.1 - 0.03 13.5 0.0 0.069 12.3 0.0 1.6 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 TTP binding domain Cnd1 PF12717.7 KOS21077.1 - 0.052 13.6 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 BUD22 PF09073.10 KOS21077.1 - 0.083 12.2 58.2 0.23 10.7 22.9 2.4 2 0 0 2 2 2 0 BUD22 DUF4481 PF14800.6 KOS21077.1 - 0.14 11.6 0.2 0.3 10.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) DUF3408 PF11888.8 KOS21077.1 - 0.23 11.6 9.5 0.4 10.8 0.5 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Rsa3 PF14615.6 KOS21077.1 - 1.2 8.8 4.6 14 5.3 0.1 3.2 3 0 0 3 3 3 0 Ribosome-assembly protein 3 RRN3 PF05327.11 KOS21077.1 - 2.9 6.3 33.1 0.039 12.5 4.5 3.0 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor RRN3 Phosphodiest PF01663.22 KOS21078.1 - 1.7e-87 294.3 0.1 2.4e-87 293.8 0.1 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOS21078.1 - 0.00029 20.3 0.1 0.43 9.9 0.0 2.4 2 0 0 2 2 2 2 Sulfatase PglZ PF08665.12 KOS21078.1 - 0.006 16.7 0.4 0.022 14.9 0.0 2.0 2 0 0 2 2 2 1 PglZ domain PBP1_TM PF14812.6 KOS21078.1 - 0.044 14.1 0.1 0.044 14.1 0.1 4.2 4 1 0 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SNF2_N PF00176.23 KOS21079.1 - 6.6e-17 61.3 0.2 1.2e-16 60.5 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 KOS21079.1 - 1.8e-16 60.4 0.2 7.3e-16 58.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_3 PF13920.6 KOS21079.1 - 1.1e-06 28.4 4.0 2.6e-06 27.2 4.0 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS21079.1 - 4.7e-05 23.3 6.4 0.00012 22.0 6.4 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOS21079.1 - 7.6e-05 22.5 7.1 0.00016 21.4 3.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ERCC3_RAD25_C PF16203.5 KOS21079.1 - 0.00026 20.3 0.2 0.00061 19.1 0.2 1.6 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase zf-RING_UBOX PF13445.6 KOS21079.1 - 0.00038 20.4 4.6 0.00092 19.2 3.2 2.2 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 KOS21079.1 - 0.00043 20.1 5.2 0.00094 19.0 5.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS21079.1 - 0.0024 18.2 6.2 0.0024 18.2 6.2 1.7 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 KOS21079.1 - 0.018 15.2 10.6 0.023 14.8 8.6 2.2 2 1 1 3 3 2 0 zinc finger of C3HC4-type, RING YL1 PF05764.13 KOS21079.1 - 0.042 14.0 12.8 0.068 13.3 12.8 1.4 1 0 0 1 1 1 0 YL1 nuclear protein zf-RING_4 PF14570.6 KOS21079.1 - 0.08 12.7 5.6 0.27 11.1 5.7 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain Rad50_zn_hook PF04423.14 KOS21079.1 - 0.099 12.5 0.9 0.3 11.0 0.1 2.2 2 0 0 2 2 1 0 Rad50 zinc hook motif AAA_33 PF13671.6 KOS21079.1 - 0.16 12.2 1.1 0.63 10.2 0.3 2.1 2 0 0 2 2 2 0 AAA domain zf-ANAPC11 PF12861.7 KOS21079.1 - 0.18 11.9 3.1 0.5 10.4 3.1 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger NOA36 PF06524.12 KOS21079.1 - 0.23 10.7 19.7 0.12 11.7 17.6 1.5 1 1 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 KOS21079.1 - 0.55 9.6 18.8 0.046 13.2 14.1 1.5 2 0 0 2 2 2 0 SDA1 Prok-RING_4 PF14447.6 KOS21079.1 - 0.72 9.8 13.0 1.2e+02 2.6 13.7 3.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-MIZ PF02891.20 KOS21079.1 - 0.97 9.2 5.7 3 7.7 5.7 1.8 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Nop14 PF04147.12 KOS21079.1 - 1.1 7.4 13.9 1.5 6.9 13.9 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KOS21079.1 - 3.8 5.7 12.5 5.7 5.1 12.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_76 PF03663.14 KOS21080.1 - 3.2e-106 355.9 7.2 4.6e-84 283.0 0.9 2.1 1 1 1 2 2 2 2 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOS21080.1 - 0.013 14.5 4.6 1.6 7.7 2.2 2.7 2 1 0 2 2 2 0 Glycosyl Hydrolase Family 88 DUF3446 PF11928.8 KOS21081.1 - 0.056 13.8 8.8 0.12 12.7 8.8 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain SR-25 PF10500.9 KOS21081.1 - 0.28 10.8 10.6 0.4 10.2 10.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AF-4 PF05110.13 KOS21081.1 - 3.2 5.7 5.7 3.9 5.4 5.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein NAT PF04768.13 KOS21082.1 - 2.9e-45 154.0 0.0 5.1e-45 153.2 0.0 1.4 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase AA_kinase PF00696.28 KOS21082.1 - 5.6e-32 111.3 0.1 9.3e-31 107.2 0.0 2.3 2 0 0 2 2 2 1 Amino acid kinase family Semialdhyde_dh PF01118.24 KOS21082.1 - 7.6e-29 100.6 0.0 1.8e-28 99.4 0.0 1.7 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain DapB_N PF01113.20 KOS21082.1 - 0.057 13.5 0.0 1.1 9.4 0.0 2.6 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Synaptobrevin PF00957.21 KOS21083.1 - 6.9e-32 109.1 0.7 8.3e-32 108.9 0.7 1.0 1 0 0 1 1 1 1 Synaptobrevin MCU PF04678.13 KOS21083.1 - 0.009 16.1 0.1 0.01 15.9 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Prominin PF05478.11 KOS21083.1 - 0.012 13.7 0.0 0.014 13.4 0.0 1.0 1 0 0 1 1 1 0 Prominin Fzo_mitofusin PF04799.13 KOS21083.1 - 0.043 13.4 0.3 0.059 12.9 0.3 1.2 1 0 0 1 1 1 0 fzo-like conserved region Fasciclin PF02469.22 KOS21084.1 - 4.6e-34 117.4 0.0 3.5e-18 66.0 0.0 2.3 2 0 0 2 2 2 2 Fasciclin domain TPR_12 PF13424.6 KOS21085.1 - 1.8e-58 194.8 72.4 1.1e-11 44.9 1.7 8.0 1 1 8 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 KOS21085.1 - 5.1e-33 112.0 34.2 3e-05 23.8 0.3 11.8 11 1 0 11 11 11 7 Tetratricopeptide repeat TPR_19 PF14559.6 KOS21085.1 - 1.2e-28 99.4 49.0 2.3e-06 28.0 0.2 10.8 2 2 10 12 12 12 10 Tetratricopeptide repeat TPR_14 PF13428.6 KOS21085.1 - 4.6e-28 95.5 41.9 0.025 15.4 0.2 12.3 10 2 2 12 12 12 8 Tetratricopeptide repeat TPR_2 PF07719.17 KOS21085.1 - 8.5e-27 91.1 29.9 0.00083 19.3 0.0 12.4 12 1 0 12 12 12 6 Tetratricopeptide repeat TPR_7 PF13176.6 KOS21085.1 - 4.8e-26 88.8 28.8 0.0019 18.1 0.3 11.9 11 1 1 12 12 12 6 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21085.1 - 4.9e-23 79.4 28.6 0.0078 16.3 0.0 12.2 12 1 0 12 12 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 KOS21085.1 - 1.2e-21 75.6 23.8 0.00064 19.4 0.2 11.0 10 1 0 10 10 10 4 Tetratricopeptide repeat TPR_6 PF13174.6 KOS21085.1 - 2.2e-17 62.4 33.4 0.42 11.4 0.3 11.6 11 0 0 11 11 11 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS21085.1 - 7.2e-15 55.0 24.0 0.0023 18.1 0.1 9.9 1 1 7 9 9 9 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 KOS21085.1 - 2e-14 54.0 35.2 0.00084 19.9 0.0 9.9 7 3 3 10 10 10 4 Tetratricopeptide repeat TPR_20 PF14561.6 KOS21085.1 - 2.3e-14 53.5 36.8 0.16 12.4 0.0 10.7 3 3 8 11 11 11 5 Tetratricopeptide repeat TPR_MalT PF17874.1 KOS21085.1 - 2e-12 47.2 24.1 1.8e-05 24.3 2.3 4.4 1 1 1 3 3 3 3 MalT-like TPR region TPR_17 PF13431.6 KOS21085.1 - 3.5e-11 42.7 16.9 0.028 14.8 0.0 9.4 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS21085.1 - 4.7e-09 36.3 9.7 1.2 9.3 0.2 6.5 2 2 4 6 6 6 4 Tetratricopeptide repeat PPR PF01535.20 KOS21085.1 - 5e-09 35.8 1.0 3.1 8.2 0.0 8.2 10 0 0 10 10 9 1 PPR repeat TPR_11 PF13414.6 KOS21085.1 - 1e-08 34.7 28.9 0.13 12.0 0.0 8.6 8 1 0 8 8 7 2 TPR repeat Paf67 PF10255.9 KOS21085.1 - 3.1e-06 26.4 0.3 0.3 10.0 0.0 3.9 3 2 1 4 4 4 2 RNA polymerase I-associated factor PAF67 DUF4248 PF14053.6 KOS21085.1 - 0.0004 20.3 3.7 3.8 7.6 0.0 4.8 5 0 0 5 5 3 1 Domain of unknown function (DUF4248) BTAD PF03704.17 KOS21085.1 - 0.0013 19.2 23.2 3.1 8.2 2.9 7.0 1 1 4 5 5 5 1 Bacterial transcriptional activator domain Foie-gras_1 PF11817.8 KOS21085.1 - 0.013 15.1 9.1 1.9 8.0 0.1 4.8 3 2 1 5 5 5 0 Foie gras liver health family 1 RPN7 PF10602.9 KOS21085.1 - 0.017 14.9 12.7 13 5.4 0.2 5.7 3 2 3 6 6 6 0 26S proteasome subunit RPN7 TPR_4 PF07721.14 KOS21085.1 - 0.027 15.1 36.7 2.1 9.2 0.0 10.3 13 1 0 13 13 8 0 Tetratricopeptide repeat DUF4752 PF15944.5 KOS21085.1 - 0.069 13.2 0.0 0.24 11.5 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) 14-3-3 PF00244.20 KOS21085.1 - 0.082 12.4 10.6 0.63 9.5 0.6 4.4 3 1 2 5 5 5 0 14-3-3 protein Clathrin PF00637.20 KOS21085.1 - 0.11 12.3 4.7 8 6.3 1.2 4.5 3 2 1 4 4 4 0 Region in Clathrin and VPS PPR_2 PF13041.6 KOS21085.1 - 0.12 12.6 2.1 83 3.5 0.0 4.6 6 0 0 6 6 3 0 PPR repeat family DUF5113 PF17140.4 KOS21085.1 - 0.18 11.6 2.7 0.77 9.5 0.1 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF5113) AAA_assoc_2 PF16193.5 KOS21085.1 - 0.73 10.2 5.7 29 5.1 1.3 3.6 1 1 1 2 2 2 0 AAA C-terminal domain DUF2225 PF09986.9 KOS21085.1 - 1.5 8.5 4.6 9.9 5.8 0.2 2.7 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF4810 PF16068.5 KOS21085.1 - 1.6 9.3 9.2 28 5.4 0.3 5.3 4 1 1 5 5 5 0 Domain of unknown function (DUF4810) Glyco_trans_2_3 PF13632.6 KOS21086.1 - 9.4e-52 175.8 2.5 9.4e-52 175.8 2.5 2.2 1 1 1 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 KOS21086.1 - 4.8e-06 26.5 0.0 1.1e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 KOS21086.1 - 0.0043 16.6 0.0 0.01 15.3 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 KOS21086.1 - 0.023 14.6 0.0 0.043 13.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Flavi_NS2A PF01005.19 KOS21086.1 - 0.033 14.3 1.1 0.097 12.8 1.1 1.7 1 0 0 1 1 1 0 Flavivirus non-structural protein NS2A Glyco_hydro_16 PF00722.21 KOS21087.1 - 2.6e-16 59.6 1.7 4.1e-16 59.0 1.7 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 TaqI_C PF12950.7 KOS21087.1 - 0.022 14.8 0.1 0.073 13.1 0.0 1.8 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain Cyclase PF04199.13 KOS21088.1 - 1.2e-16 61.2 0.1 2.1e-16 60.4 0.1 1.4 1 0 0 1 1 1 1 Putative cyclase ThuA PF06283.11 KOS21088.1 - 0.047 13.9 0.0 0.069 13.4 0.0 1.3 1 0 0 1 1 1 0 Trehalose utilisation DUF22 PF01629.16 KOS21088.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF22 SH3_1 PF00018.28 KOS21090.1 - 2.7e-05 23.7 0.0 5.2e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS21090.1 - 0.038 13.9 0.0 0.076 12.9 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain Tom22 PF04281.13 KOS21091.1 - 9.7e-50 168.0 0.0 1.1e-49 167.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 ELFV_dehydrog PF00208.21 KOS21092.1 - 9.5e-64 215.4 0.0 1.5e-63 214.8 0.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 KOS21092.1 - 7e-20 70.3 0.0 3e-15 54.9 0.0 2.2 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 KOS21092.1 - 0.0046 16.8 0.0 0.035 14.0 0.0 2.3 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain AAR2 PF05282.11 KOS21093.1 - 2.7e-44 152.0 0.0 6.4e-44 150.8 0.0 1.5 1 1 0 1 1 1 1 AAR2 protein DUF5302 PF17227.2 KOS21093.1 - 0.2 12.6 4.0 0.61 11.1 4.0 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5302) Band_7 PF01145.25 KOS21093.1 - 4 7.4 4.9 7.3 6.6 4.9 1.3 1 0 0 1 1 1 0 SPFH domain / Band 7 family zf-C2H2 PF00096.26 KOS21094.1 - 0.085 13.3 0.2 0.19 12.3 0.2 1.6 1 0 0 1 1 1 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 KOS21094.1 - 0.16 12.6 3.5 0.31 11.7 3.5 1.5 1 1 0 1 1 1 0 FOXP coiled-coil domain DUF1682 PF07946.14 KOS21094.1 - 0.3 10.2 5.0 0.36 10.0 5.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) YabA PF06156.13 KOS21094.1 - 4.7 7.9 8.2 1.3 9.7 0.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Ribosomal_L32e PF01655.18 KOS21095.1 - 1.1e-49 167.4 0.4 1.1e-49 167.4 0.4 1.8 2 0 0 2 2 2 1 Ribosomal protein L32 Ribosomal_S9 PF00380.19 KOS21096.1 - 1.8e-33 115.6 0.1 2e-33 115.5 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Pkinase PF00069.25 KOS21097.1 - 2.7e-60 203.9 0.0 4.3e-60 203.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21097.1 - 4.2e-45 154.1 0.0 7e-45 153.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS21097.1 - 0.0021 16.9 0.4 0.005 15.7 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 KOS21097.1 - 0.1 11.9 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 Kinase-like DUF755 PF05501.11 KOS21097.1 - 7.7 6.8 6.6 85 3.4 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) A_deaminase PF00962.22 KOS21098.1 - 9.4e-21 74.5 0.0 1.9e-20 73.5 0.0 1.4 1 1 0 1 1 1 1 Adenosine/AMP deaminase ThrE PF06738.12 KOS21099.1 - 8.3e-71 238.2 8.0 2.1e-67 227.0 4.8 2.2 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 KOS21099.1 - 0.0022 18.1 0.3 0.0022 18.1 0.3 3.5 3 0 0 3 3 3 1 Threonine/Serine exporter, ThrE MMR1 PF08505.10 KOS21099.1 - 0.19 12.0 7.7 0.075 13.3 3.8 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein Spem1 PF15670.5 KOS21099.1 - 0.69 9.4 6.5 1.6 8.3 6.5 1.6 1 0 0 1 1 1 0 Spermatid maturation protein 1 SARAF PF06682.12 KOS21099.1 - 9.7 5.7 8.8 23 4.5 8.8 1.6 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis AA_permease PF00324.21 KOS21101.1 - 7.4e-122 407.4 49.8 9.1e-122 407.1 49.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS21101.1 - 6.1e-29 101.1 53.9 7.4e-29 100.8 53.9 1.1 1 0 0 1 1 1 1 Amino acid permease Aa_trans PF01490.18 KOS21102.1 - 4.6e-90 302.3 16.2 6.5e-90 301.8 16.2 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PBP1_TM PF14812.6 KOS21102.1 - 0.47 10.9 2.8 0.89 10.0 2.8 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SAP130_C PF16014.5 KOS21103.1 - 0.013 14.6 2.9 0.017 14.2 2.9 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus DUF4140 PF13600.6 KOS21103.1 - 0.22 12.0 2.7 1.7 9.1 0.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ABC_tran PF00005.27 KOS21104.1 - 1.1e-48 165.3 0.0 1.8e-26 93.3 0.0 3.9 2 2 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 KOS21104.1 - 4.3e-13 49.7 4.4 0.00048 20.0 0.3 4.6 2 2 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOS21104.1 - 1.2e-12 47.8 0.7 0.00026 20.5 0.0 4.4 3 2 0 4 4 3 2 RecF/RecN/SMC N terminal domain Chromo PF00385.24 KOS21104.1 - 2.5e-09 36.9 0.0 5.2e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 KOS21104.1 - 2.9e-09 37.7 0.7 0.00012 22.6 0.0 2.7 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 KOS21104.1 - 1.1e-07 31.9 0.1 0.00079 19.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 KOS21104.1 - 2.1e-07 31.0 0.0 0.0037 17.3 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 KOS21104.1 - 4.6e-07 29.5 0.5 0.0065 16.2 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 KOS21104.1 - 5.4e-05 23.5 0.2 0.7 10.2 0.0 3.2 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOS21104.1 - 0.00015 22.3 0.0 0.22 12.0 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_15 PF13175.6 KOS21104.1 - 0.0002 21.2 0.1 0.18 11.5 0.1 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_28 PF13521.6 KOS21104.1 - 0.00031 21.0 0.0 0.028 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOS21104.1 - 0.00071 19.8 0.0 2.4 8.3 0.0 2.9 2 0 0 2 2 2 2 AAA domain DUF87 PF01935.17 KOS21104.1 - 0.0011 19.1 1.0 0.42 10.7 0.1 3.2 3 0 0 3 3 2 1 Helicase HerA, central domain MeaB PF03308.16 KOS21104.1 - 0.0015 17.6 0.3 0.38 9.7 0.1 2.4 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RNA_helicase PF00910.22 KOS21104.1 - 0.0019 18.5 0.1 3.4 8.1 0.0 2.7 2 0 0 2 2 2 1 RNA helicase NACHT PF05729.12 KOS21104.1 - 0.0046 16.9 0.1 2.4 8.1 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_13 PF13166.6 KOS21104.1 - 0.0056 15.4 0.0 1 7.9 0.0 2.4 2 0 0 2 2 2 1 AAA domain SbcCD_C PF13558.6 KOS21104.1 - 0.0078 16.4 0.0 4 7.8 0.0 3.3 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit AAA PF00004.29 KOS21104.1 - 0.0085 16.5 0.1 6 7.3 0.0 3.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 KOS21104.1 - 0.011 15.5 1.6 2.3 7.9 0.0 3.2 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 KOS21104.1 - 0.012 15.4 1.1 0.56 9.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 KOS21104.1 - 0.013 15.2 0.1 0.82 9.4 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 KOS21104.1 - 0.018 15.4 1.0 2.4 8.5 0.0 3.6 4 1 0 4 4 3 0 AAA ATPase domain Dynamin_N PF00350.23 KOS21104.1 - 0.021 14.9 0.0 0.39 10.7 0.0 2.6 2 0 0 2 2 2 0 Dynamin family SR-25 PF10500.9 KOS21104.1 - 0.026 14.1 1.0 0.045 13.4 1.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Roc PF08477.13 KOS21104.1 - 0.027 14.7 0.0 5.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_27 PF13514.6 KOS21104.1 - 0.028 14.0 0.6 7.6 6.1 0.0 2.7 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 KOS21104.1 - 0.035 13.3 0.1 2.2 7.4 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain DUF3584 PF12128.8 KOS21104.1 - 0.035 11.6 0.8 3 5.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) AAA_14 PF13173.6 KOS21104.1 - 0.04 13.9 0.0 6.7 6.8 0.0 2.9 3 0 0 3 3 2 0 AAA domain DUF815 PF05673.13 KOS21104.1 - 0.057 12.6 0.1 3.4 6.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TsaE PF02367.17 KOS21104.1 - 0.07 13.1 0.2 18 5.3 0.1 2.6 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 KOS21104.1 - 0.078 12.9 0.2 19 5.1 0.3 3.0 3 0 0 3 3 2 0 NTPase cobW PF02492.19 KOS21104.1 - 0.11 12.0 0.2 25 4.4 0.1 2.9 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain CLP1_P PF16575.5 KOS21104.1 - 0.12 12.2 1.2 47 3.7 0.1 3.4 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Septin PF00735.18 KOS21104.1 - 0.13 11.5 0.0 13 5.0 0.0 2.4 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 KOS21104.1 - 0.15 11.6 0.1 15 5.0 0.0 2.7 2 0 0 2 2 2 0 P-loop containing dynein motor region ALF PF03752.13 KOS21104.1 - 0.43 10.6 1.9 8.3 6.5 0.2 3.3 3 0 0 3 3 3 0 Short repeats of unknown function DHHC PF01529.20 KOS21105.1 - 7.4e-37 126.4 8.3 7.4e-37 126.4 8.3 1.8 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF4064 PF13273.6 KOS21105.1 - 0.065 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) Yip1 PF04893.17 KOS21105.1 - 0.37 10.5 7.0 0.14 11.8 0.2 2.1 2 0 0 2 2 2 0 Yip1 domain Imm17 PF15562.6 KOS21105.1 - 0.48 10.3 2.3 23 4.9 0.0 2.9 3 0 0 3 3 3 0 Immunity protein 17 HisKA_3 PF07730.13 KOS21106.1 - 0.051 14.1 1.1 0.1 13.2 1.1 1.5 1 0 0 1 1 1 0 Histidine kinase zf-His_Me_endon PF05551.11 KOS21106.1 - 0.086 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Zinc-binding loop region of homing endonuclease ACC_epsilon PF13822.6 KOS21106.1 - 3 8.6 10.3 1.1 9.9 4.2 2.3 1 1 1 2 2 2 0 Acyl-CoA carboxylase epsilon subunit PNP_UDP_1 PF01048.20 KOS21107.1 - 8.9e-11 41.5 0.3 6.2e-10 38.7 0.3 1.9 1 1 0 1 1 1 1 Phosphorylase superfamily UbiA PF01040.18 KOS21108.1 - 8.1e-22 77.7 10.5 1e-21 77.4 10.5 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family Ribosomal_S16 PF00886.19 KOS21109.1 - 5.6e-26 90.4 0.1 7.4e-26 90.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 NAD_binding_8 PF13450.6 KOS21111.1 - 5.4e-13 49.0 0.0 2.1e-12 47.1 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 KOS21111.1 - 2.6e-08 33.6 1.5 0.0023 17.3 0.0 3.2 3 0 0 3 3 3 3 Flavin containing amine oxidoreductase FAD_binding_2 PF00890.24 KOS21111.1 - 2.6e-07 30.1 1.3 0.00022 20.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 KOS21111.1 - 0.0053 16.0 0.0 0.014 14.7 0.0 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS21111.1 - 0.0078 16.7 0.0 0.02 15.4 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOS21111.1 - 0.031 13.5 0.0 0.062 12.5 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 KOS21111.1 - 0.076 13.0 1.3 5.6 6.9 0.1 3.6 2 2 2 4 4 4 0 FAD-NAD(P)-binding Gly_transf_sug PF04488.15 KOS21112.1 - 3.4e-15 56.5 0.0 2e-14 54.0 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase sugar-binding region containing DXD motif oligo_HPY PF08352.12 KOS21112.1 - 0.17 12.4 0.2 1.1 9.8 0.0 2.4 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Ribosomal_L35Ae PF01247.18 KOS21113.1 - 7.1e-40 135.1 0.1 8e-40 134.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 KOS21113.1 - 0.001 19.2 0.0 1.1 9.5 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain G6PD_C PF02781.16 KOS21114.1 - 1.1e-114 382.5 0.0 1.7e-114 381.9 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 KOS21114.1 - 2.5e-59 200.9 0.0 4.6e-59 200.0 0.0 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Med14 PF08638.11 KOS21115.1 - 3.4e-62 209.3 0.1 6.1e-62 208.4 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit MED14 Amino_oxidase PF01593.24 KOS21116.1 - 2.9e-25 89.5 1.8 4.7e-25 88.8 1.8 1.3 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS21116.1 - 7.6e-13 48.5 0.2 2.7e-12 46.7 0.2 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS21116.1 - 7.1e-08 32.4 1.9 1.7e-05 24.6 0.9 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS21116.1 - 0.00078 18.8 0.0 0.0052 16.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS21116.1 - 0.0019 17.5 0.0 0.0032 16.8 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 KOS21116.1 - 0.0041 17.7 0.1 0.26 11.9 0.1 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS21116.1 - 0.0097 15.9 0.3 0.2 11.6 0.1 2.6 2 0 0 2 2 2 1 FAD-NAD(P)-binding Trp_halogenase PF04820.14 KOS21116.1 - 0.01 14.7 0.1 0.017 14.0 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase FAD_binding_2 PF00890.24 KOS21116.1 - 0.024 13.7 0.2 0.052 12.6 0.2 1.6 1 0 0 1 1 1 0 FAD binding domain MCRA PF06100.11 KOS21116.1 - 0.061 12.1 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 MCRA family SSP160 PF06933.11 KOS21116.1 - 1.5 6.9 7.9 2.1 6.4 7.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 zf-CCCH_2 PF14608.6 KOS21117.1 - 3e-16 59.2 52.6 8.2e-06 26.1 9.7 5.5 5 1 0 5 5 5 5 RNA-binding, Nab2-type zinc finger Nab2 PF11517.8 KOS21117.1 - 0.021 15.1 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Aminotran_1_2 PF00155.21 KOS21118.1 - 7.4e-10 38.5 0.0 1.1e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 KOS21118.1 - 3.4e-05 22.8 0.0 6.7e-05 21.8 0.0 1.4 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase DegT_DnrJ_EryC1 PF01041.17 KOS21118.1 - 0.022 14.1 0.0 0.17 11.1 0.0 2.1 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family RIC1 PF07064.13 KOS21119.1 - 1.6e-86 289.9 0.0 2.2e-86 289.4 0.0 1.2 1 0 0 1 1 1 1 RIC1 ANAPC4_WD40 PF12894.7 KOS21119.1 - 0.0061 16.8 0.0 3.6 8.0 0.0 4.6 4 2 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS21119.1 - 0.018 15.9 4.5 4.5 8.3 0.2 4.6 4 0 0 4 4 4 0 WD domain, G-beta repeat CK_II_beta PF01214.18 KOS21120.1 - 2.1e-74 249.3 0.2 3.5e-74 248.5 0.2 1.4 1 0 0 1 1 1 1 Casein kinase II regulatory subunit SKA1 PF07160.12 KOS21120.1 - 0.023 14.6 0.4 0.033 14.1 0.4 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 FAM176 PF14851.6 KOS21120.1 - 0.48 10.1 5.9 2.4 7.8 1.7 2.2 2 0 0 2 2 2 0 FAM176 family PAP2 PF01569.21 KOS21121.1 - 1.7e-20 73.1 1.1 1.7e-20 73.1 1.1 2.4 2 1 0 2 2 2 1 PAP2 superfamily DUF2207 PF09972.9 KOS21121.1 - 0.99 8.1 2.8 0.77 8.5 0.4 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Ribosomal_L2_C PF03947.18 KOS21122.1 - 6.5e-32 110.4 0.9 6.5e-32 110.4 0.9 2.0 2 0 0 2 2 2 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 KOS21122.1 - 2.3e-23 81.9 2.0 3.3e-23 81.4 0.9 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain FAD_binding_3 PF01494.19 KOS21123.1 - 1.6e-10 40.8 0.0 2.1e-10 40.4 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS21123.1 - 2.1e-09 37.4 4.2 1.1e-05 25.2 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS21123.1 - 2.8e-08 33.3 0.1 0.00035 19.9 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOS21123.1 - 6.5e-06 25.7 0.1 1.5e-05 24.5 0.0 1.6 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 KOS21123.1 - 0.00017 21.0 0.1 0.16 11.2 1.2 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS21123.1 - 0.00079 18.4 2.1 0.31 9.8 0.1 2.4 3 0 0 3 3 3 2 Tryptophan halogenase NAD_binding_9 PF13454.6 KOS21123.1 - 0.0015 18.5 1.0 0.023 14.7 0.0 2.3 2 0 0 2 2 2 1 FAD-NAD(P)-binding HI0933_like PF03486.14 KOS21123.1 - 0.0039 16.0 2.3 0.62 8.7 0.0 2.9 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 KOS21123.1 - 0.006 16.8 2.1 0.007 16.6 0.3 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 KOS21123.1 - 0.018 14.1 3.2 0.037 13.1 0.5 2.4 2 1 0 2 2 2 0 Lycopene cyclase protein Thi4 PF01946.17 KOS21123.1 - 0.051 12.8 0.1 0.091 12.0 0.1 1.5 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KOS21123.1 - 0.14 12.7 0.7 26 5.5 0.3 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS21123.1 - 0.15 11.1 2.3 0.14 11.2 0.3 1.8 2 0 0 2 2 2 0 FAD binding domain TetR_C_27 PF17935.1 KOS21124.1 - 0.014 15.5 0.2 0.018 15.1 0.2 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DNA_Packaging PF11053.8 KOS21124.1 - 0.014 15.3 0.1 0.016 15.1 0.1 1.0 1 0 0 1 1 1 0 Terminase DNA packaging enzyme Ribosomal_L34e PF01199.18 KOS21125.1 - 2e-44 149.8 2.0 2.8e-44 149.3 2.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L34e FhuF_C PF11575.8 KOS21125.1 - 0.79 9.7 6.0 1.7 8.7 0.3 2.7 3 0 0 3 3 3 0 FhuF 2Fe-2S C-terminal domain PI-PLC-X PF00388.19 KOS21126.1 - 2e-45 153.9 0.0 3.1e-45 153.3 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOS21126.1 - 3.8e-34 117.5 0.0 5.8e-34 116.9 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain C2 PF00168.30 KOS21126.1 - 0.11 12.9 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 C2 domain Cys_Knot_tox PF17486.2 KOS21127.1 - 5 7.4 32.7 29 5.0 0.1 7.1 4 1 3 7 7 7 0 Cystine knot toxins Trypan_PARP PF05887.11 KOS21127.1 - 5.6 6.9 25.3 0.26 11.3 7.7 3.4 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) TRAPPC10 PF12584.8 KOS21128.1 - 9.5e-23 80.6 0.0 1.9e-22 79.7 0.0 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 DUF4667 PF15700.5 KOS21128.1 - 0.33 11.0 14.0 0.34 11.0 2.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4667) FAM104 PF15434.6 KOS21128.1 - 4.3 7.9 9.8 5.2 7.7 1.9 3.0 2 0 0 2 2 2 0 Family 104 SUZ PF12752.7 KOS21128.1 - 7.7 7.4 5.9 13 6.7 0.6 3.1 2 0 0 2 2 2 0 SUZ domain SR-25 PF10500.9 KOS21128.1 - 8.1 6.0 35.6 1.9 8.0 17.1 2.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Aldo_ket_red PF00248.21 KOS21129.1 - 3.4e-33 115.1 0.0 1.5e-32 113.0 0.0 1.8 1 1 0 1 1 1 1 Aldo/keto reductase family Ribosomal_S27e PF01667.17 KOS21130.1 - 4e-28 96.9 6.9 4.9e-28 96.6 6.9 1.1 1 0 0 1 1 1 1 Ribosomal protein S27 zf-C2HC5 PF06221.13 KOS21130.1 - 0.66 10.0 6.4 0.61 10.1 4.1 2.0 2 1 0 2 2 2 0 Putative zinc finger motif, C2HC5-type RNR_inhib PF08591.10 KOS21131.1 - 1.3e-30 106.8 0.0 2.1e-30 106.2 0.0 1.3 1 0 0 1 1 1 1 Ribonucleotide reductase inhibitor PRP38 PF03371.15 KOS21132.1 - 7.9e-55 185.4 0.0 9.4e-55 185.1 0.0 1.1 1 0 0 1 1 1 1 PRP38 family Paf1 PF03985.13 KOS21132.1 - 0.0063 15.6 7.4 0.0075 15.3 7.4 1.1 1 0 0 1 1 1 1 Paf1 CDC45 PF02724.14 KOS21132.1 - 0.11 10.8 11.5 0.13 10.5 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 KOS21132.1 - 2.4 6.1 17.5 3.2 5.7 17.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi CobT PF06213.12 KOS21132.1 - 4.4 6.6 15.6 6.3 6.1 15.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4637 PF15470.6 KOS21132.1 - 8.9 6.0 14.7 14 5.4 14.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SIP1 PF04938.12 KOS21134.1 - 1.7e-07 31.2 0.0 0.0019 17.9 0.0 3.0 2 1 0 2 2 2 2 Survival motor neuron (SMN) interacting protein 1 (SIP1) Amidase PF01425.21 KOS21135.1 - 1.7e-108 363.5 0.1 2.2e-108 363.1 0.1 1.1 1 0 0 1 1 1 1 Amidase Abhydrolase_6 PF12697.7 KOS21136.1 - 5e-15 56.7 13.3 5e-15 56.7 13.3 2.8 1 1 2 3 3 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS21136.1 - 9e-12 45.2 0.1 5.7e-11 42.5 0.1 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS21136.1 - 8.8e-11 41.5 0.1 1.5e-08 34.2 0.0 2.9 3 1 0 3 3 3 1 Serine aminopeptidase, S33 DSPc PF00782.20 KOS21136.1 - 8.2e-09 35.4 0.0 1.5e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Thioesterase PF00975.20 KOS21136.1 - 4.6e-05 23.6 0.0 0.0001 22.5 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain PTPlike_phytase PF14566.6 KOS21136.1 - 0.0029 17.7 0.1 0.0083 16.3 0.0 1.7 2 0 0 2 2 2 1 Inositol hexakisphosphate PGAP1 PF07819.13 KOS21136.1 - 0.0052 16.5 0.0 0.22 11.2 0.0 2.2 2 0 0 2 2 2 1 PGAP1-like protein Y_phosphatase PF00102.27 KOS21136.1 - 0.015 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Nitroreductase PF00881.24 KOS21136.1 - 0.1 12.6 0.5 0.2 11.7 0.5 1.4 1 0 0 1 1 1 0 Nitroreductase family Esterase PF00756.20 KOS21136.1 - 0.1 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Spt20 PF12090.8 KOS21136.1 - 0.37 10.4 3.4 0.54 9.8 3.4 1.1 1 0 0 1 1 1 0 Spt20 family M20_dimer PF07687.14 KOS21137.1 - 1.1e-17 63.9 0.0 2.2e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 KOS21137.1 - 5.4e-16 58.9 1.2 3.8e-15 56.2 1.2 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 KOS21137.1 - 0.00053 19.7 0.0 0.00079 19.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 MFS_1 PF07690.16 KOS21138.1 - 2.5e-46 158.2 47.6 2.5e-46 158.2 47.6 2.0 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS21138.1 - 1.4e-09 36.9 22.3 2.1e-09 36.4 22.3 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) Sugar_tr PF00083.24 KOS21139.1 - 2.9e-24 85.8 23.5 2.6e-14 53.0 5.5 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter DUF2686 PF10887.8 KOS21139.1 - 0.027 13.4 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2686) DUF3611 PF12263.8 KOS21139.1 - 0.049 13.5 0.3 0.049 13.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) Pkinase PF00069.25 KOS21140.1 - 4.6e-61 206.5 0.0 7.2e-38 130.5 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21140.1 - 6.8e-28 97.7 0.0 5.6e-20 71.7 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Response_reg PF00072.24 KOS21140.1 - 9.7e-16 57.9 0.0 2.1e-15 56.9 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain Kinase-like PF14531.6 KOS21140.1 - 3.9e-07 29.7 0.1 0.00034 20.0 0.0 2.8 3 0 0 3 3 3 2 Kinase-like APH PF01636.23 KOS21140.1 - 7.7e-05 22.7 0.0 0.0044 17.0 0.1 2.7 1 1 1 2 2 2 1 Phosphotransferase enzyme family PAS_9 PF13426.7 KOS21140.1 - 0.00075 19.7 0.0 0.0022 18.2 0.0 1.8 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 KOS21140.1 - 0.00097 19.1 0.0 0.0027 17.7 0.0 1.8 1 0 0 1 1 1 1 PAS fold Haspin_kinase PF12330.8 KOS21140.1 - 0.0078 15.2 0.0 0.014 14.3 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS21140.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 KOS21140.1 - 0.075 12.1 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 DUF89 PF01937.19 KOS21140.1 - 0.17 10.8 0.0 0.5 9.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF89 Got1 PF04178.12 KOS21141.1 - 5.4e-34 117.0 16.2 6.9e-34 116.7 16.2 1.1 1 0 0 1 1 1 1 Got1/Sft2-like family HLH PF00010.26 KOS21142.1 - 2.4e-12 46.6 0.0 1.4e-11 44.2 0.0 2.1 1 1 0 1 1 1 1 Helix-loop-helix DNA-binding domain La PF05383.17 KOS21144.1 - 3.7e-19 68.5 0.0 6e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 La domain zf-C2H2 PF00096.26 KOS21146.1 - 0.00037 20.8 5.4 3.5 8.3 1.1 3.4 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS21146.1 - 0.0015 19.2 9.8 1.7 9.7 0.0 4.1 3 1 0 3 3 3 2 C2H2-type zinc finger zf-Di19 PF05605.12 KOS21146.1 - 0.27 11.6 6.3 16 5.9 0.0 3.1 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding NPR3 PF03666.13 KOS21147.1 - 1.6e-142 475.6 0.2 1.6e-142 475.6 0.2 2.2 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 TFIIA PF03153.13 KOS21147.1 - 0.0003 20.9 32.8 0.0011 19.1 26.8 2.3 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KOS21147.1 - 0.00053 19.7 22.1 0.00053 19.7 22.1 1.8 2 0 0 2 2 2 1 Spt20 family Choline_kinase PF01633.20 KOS21148.1 - 5.4e-48 163.4 0.0 8.7e-48 162.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 KOS21148.1 - 4.4e-11 43.2 0.4 7.8e-11 42.4 0.4 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family EcKinase PF02958.20 KOS21148.1 - 2.9e-06 26.8 0.0 4.5e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 KOS21148.1 - 0.00047 19.1 0.0 0.00087 18.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1679) IL3 PF02059.15 KOS21148.1 - 0.035 14.2 0.1 3.6 7.7 0.0 3.2 4 0 0 4 4 4 0 Interleukin-3 TFIIS_C PF01096.18 KOS21149.1 - 9.6e-20 70.2 3.3 9.6e-20 70.2 3.3 2.7 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 KOS21149.1 - 3.4e-05 23.6 0.2 3.4e-05 23.6 0.2 2.7 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit Zn_Tnp_IS1595 PF12760.7 KOS21149.1 - 0.0032 17.4 9.3 0.014 15.3 0.7 2.6 2 1 0 2 2 2 2 Transposase zinc-ribbon domain Elf1 PF05129.13 KOS21149.1 - 0.028 14.5 5.5 0.45 10.6 0.1 2.5 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like Desulfoferrod_N PF06397.12 KOS21149.1 - 0.044 13.4 0.3 3.5 7.3 0.0 2.5 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Zn_ribbon_recom PF13408.6 KOS21149.1 - 0.16 12.5 2.9 1.6 9.3 0.0 2.8 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain Fer4_9 PF13187.6 KOS21149.1 - 3.2 8.0 11.0 0.62 10.3 3.4 2.5 2 1 0 2 2 2 0 4Fe-4S dicluster domain Ank_4 PF13637.6 KOS21150.1 - 4.7e-08 33.4 0.0 1.2e-05 25.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS21150.1 - 3.2e-07 30.1 0.1 0.021 15.3 0.0 3.9 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 KOS21150.1 - 2.5e-06 28.0 0.0 5.6e-06 26.8 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 KOS21150.1 - 5.9e-05 23.3 0.1 0.86 10.0 0.0 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOS21150.1 - 0.0024 18.3 0.0 0.85 10.2 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat CD34_antigen PF06365.12 KOS21150.1 - 0.037 13.6 1.7 0.058 13.0 1.7 1.2 1 0 0 1 1 1 0 CD34/Podocalyxin family GPI2 PF06432.11 KOS21151.1 - 3.3e-130 433.6 0.0 3.8e-130 433.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase CFEM PF05730.11 KOS21152.1 - 8.9e-12 44.9 12.2 1.9e-11 43.9 12.2 1.6 1 0 0 1 1 1 1 CFEM domain Metallophos PF00149.28 KOS21153.1 - 3.3e-08 34.3 0.0 8.9e-08 32.9 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOS21153.1 - 1.4e-06 28.6 0.0 0.0039 17.4 0.0 2.4 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain Transp_inhibit PF18791.1 KOS21153.1 - 0.11 12.0 0.1 0.11 12.0 0.1 1.8 2 0 0 2 2 2 0 Transport inhibitor response 1 protein domain Med31 PF05669.12 KOS21154.1 - 3.3e-37 126.4 3.2 3.8e-37 126.2 3.2 1.0 1 0 0 1 1 1 1 SOH1 WD40 PF00400.32 KOS21155.1 - 1.7e-08 34.9 18.8 0.00058 20.6 0.6 4.6 4 0 0 4 4 4 3 WD domain, G-beta repeat Zn_ribbon_17 PF17120.5 KOS21155.1 - 1.2e-07 31.2 10.1 3e-07 30.0 10.1 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type RWD PF05773.22 KOS21155.1 - 5e-06 26.8 0.1 1.1e-05 25.7 0.1 1.5 1 0 0 1 1 1 1 RWD domain zf-RING_2 PF13639.6 KOS21155.1 - 0.0074 16.6 6.1 0.019 15.3 6.1 1.7 1 0 0 1 1 1 1 Ring finger domain Arabinose_Isome PF02610.15 KOS21155.1 - 0.23 10.6 0.0 0.43 9.8 0.0 1.3 1 0 0 1 1 1 0 L-arabinose isomerase zinc_ribbon_16 PF17034.5 KOS21155.1 - 0.6 10.3 5.2 1.3 9.2 5.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family Abhydrolase_6 PF12697.7 KOS21157.1 - 2e-16 61.3 1.8 2.4e-16 61.0 1.8 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS21157.1 - 1.4e-11 44.6 0.1 2.3e-10 40.6 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS21157.1 - 9.7e-10 38.1 0.3 2.6e-08 33.4 0.3 2.2 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOS21157.1 - 2.7e-06 27.0 0.0 0.00094 18.7 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase family DLH PF01738.18 KOS21157.1 - 0.0001 21.9 0.0 0.00037 20.1 0.0 1.8 2 0 0 2 2 2 1 Dienelactone hydrolase family BAAT_C PF08840.11 KOS21157.1 - 0.0049 16.8 0.0 0.29 11.0 0.0 2.1 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 KOS21157.1 - 0.006 16.2 0.0 0.051 13.2 0.0 2.1 1 1 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Thioesterase PF00975.20 KOS21157.1 - 0.014 15.6 0.0 0.021 14.9 0.0 1.6 1 1 0 1 1 1 0 Thioesterase domain FSH1 PF03959.13 KOS21157.1 - 0.17 11.5 0.0 6.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Serine hydrolase (FSH1) PGAP1 PF07819.13 KOS21157.1 - 0.19 11.4 0.0 0.38 10.4 0.0 1.5 1 0 0 1 1 1 0 PGAP1-like protein PHP PF02811.19 KOS21159.1 - 3.3e-09 37.3 0.0 5.1e-09 36.6 0.0 1.4 1 1 0 1 1 1 1 PHP domain Hist_deacetyl PF00850.19 KOS21160.1 - 1.3e-52 179.2 0.1 2.3e-52 178.4 0.1 1.4 1 0 0 1 1 1 1 Histone deacetylase domain DUF4244 PF14029.6 KOS21161.1 - 0.5 9.8 3.1 1.1 8.8 3.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4244) DUF5480 PF17576.2 KOS21161.1 - 1.4 9.0 0.0 1.4 9.0 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5480) TGT PF01702.18 KOS21162.1 - 3.3e-130 434.3 0.0 3.7e-130 434.1 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Mit_ribos_Mrp51 PF11709.8 KOS21163.1 - 3.3e-112 375.7 0.0 3.9e-112 375.5 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit Ribosomal_S17e PF00833.18 KOS21164.1 - 8.6e-57 190.3 0.1 1.2e-56 189.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal S17 RPAP2_Rtr1 PF04181.13 KOS21165.1 - 3.2e-23 81.8 0.0 5e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family SH3_1 PF00018.28 KOS21166.1 - 7e-12 44.8 0.1 1.2e-11 44.0 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS21166.1 - 2.3e-11 43.4 0.1 9.8e-11 41.3 0.1 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 KOS21166.1 - 4.2e-11 42.4 0.0 7.5e-11 41.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain TFIIA PF03153.13 KOS21166.1 - 0.026 14.5 18.1 0.036 14.1 18.1 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 KOS21166.1 - 0.054 12.8 19.9 0.086 12.1 19.9 1.2 1 0 0 1 1 1 0 NOA36 protein PI-PLC-X PF00388.19 KOS21166.1 - 0.25 11.0 0.2 0.39 10.3 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain Glyco_transf_20 PF00982.21 KOS21167.1 - 2.1e-162 541.1 0.1 2.8e-162 540.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOS21167.1 - 7.7e-43 146.3 0.0 5.8e-42 143.4 0.0 2.0 2 0 0 2 2 2 1 Trehalose-phosphatase Glyco_transf_5 PF08323.11 KOS21167.1 - 0.11 12.2 0.2 0.2 11.3 0.2 1.4 1 0 0 1 1 1 0 Starch synthase catalytic domain Peptidase_C14 PF00656.22 KOS21168.1 - 1.7e-61 208.3 0.0 2.2e-61 208.0 0.0 1.1 1 0 0 1 1 1 1 Caspase domain WW PF00397.26 KOS21169.1 - 2.7e-09 36.9 4.3 8.3e-09 35.4 4.3 1.9 1 0 0 1 1 1 1 WW domain DUF2076 PF09849.9 KOS21169.1 - 1.5 8.8 26.5 31 4.5 26.5 2.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) PI-PLC-X PF00388.19 KOS21171.1 - 1.5e-57 193.2 0.0 2.3e-57 192.6 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 KOS21171.1 - 2.1e-38 131.2 0.0 3.5e-38 130.5 0.0 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, Y domain HisKA_3 PF07730.13 KOS21171.1 - 0.27 11.8 1.1 6.4 7.4 0.3 3.1 3 0 0 3 3 3 0 Histidine kinase DUF2732 PF10809.8 KOS21172.1 - 0.01 15.7 0.0 0.022 14.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2732) Sgf11 PF08209.11 KOS21172.1 - 0.019 14.5 3.2 0.019 14.5 3.2 1.7 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) zf_UBZ PF18439.1 KOS21172.1 - 0.58 9.8 1.9 7.5 6.2 0.2 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger PGA2 PF07543.12 KOS21172.1 - 1.3 9.0 5.4 14 5.6 1.8 2.7 2 0 0 2 2 2 0 Protein trafficking PGA2 Pro_isomerase PF00160.21 KOS21173.1 - 3.6e-51 173.6 0.0 4e-51 173.4 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Peptidase_A22B PF04258.13 KOS21174.1 - 2.3e-53 181.6 0.0 3.4e-33 115.4 0.0 2.3 2 1 0 2 2 2 2 Signal peptide peptidase Zip PF02535.22 KOS21174.1 - 9.6 5.3 8.5 16 4.6 0.0 2.7 2 0 0 2 2 2 0 ZIP Zinc transporter ACPS PF01648.20 KOS21175.1 - 2.1e-07 31.1 0.2 5.6e-07 29.7 0.2 1.7 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily RCDG1 PF15725.5 KOS21175.1 - 0.058 13.8 1.4 0.12 12.8 1.4 1.5 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Thaumatin PF00314.17 KOS21176.1 - 1e-41 143.0 2.6 1.3e-41 142.6 2.6 1.1 1 0 0 1 1 1 1 Thaumatin family Glyco_hydro_64 PF16483.5 KOS21176.1 - 0.021 14.1 0.0 1.4 8.1 0.0 2.1 2 0 0 2 2 2 0 Beta-1,3-glucanase HSP70 PF00012.20 KOS21177.1 - 2.1e-10 39.5 0.2 2.7e-10 39.1 0.2 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS21177.1 - 0.0061 15.4 0.1 0.073 11.9 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hexokinase_1 PF00349.21 KOS21178.1 - 3.4e-74 249.0 0.0 5.4e-74 248.4 0.0 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 KOS21178.1 - 5.5e-74 248.6 0.0 7.8e-74 248.1 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Acetyltransf_1 PF00583.25 KOS21179.1 - 0.00015 22.0 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family GBS_Bsp-like PF08481.10 KOS21179.1 - 0.16 12.1 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 GBS Bsp-like repeat SPX PF03105.19 KOS21179.1 - 3.3 7.5 17.1 0.5 10.2 6.9 2.1 2 0 0 2 2 2 0 SPX domain DUF3716 PF12511.8 KOS21180.1 - 5.3e-11 42.4 5.2 9.4e-11 41.6 5.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3716) DLP_helical PF18709.1 KOS21180.1 - 0.0025 17.1 5.5 0.0043 16.3 5.5 1.2 1 0 0 1 1 1 1 Dynamin-like helical domain DEAD PF00270.29 KOS21181.1 - 1.2e-49 168.5 0.0 2e-48 164.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS21181.1 - 2.2e-32 111.7 0.1 1.5e-31 109.0 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS21181.1 - 2.5e-05 24.3 0.0 0.0001 22.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 KOS21181.1 - 0.0017 17.2 0.1 0.14 10.9 0.0 2.2 2 0 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 KOS21181.1 - 0.027 14.8 0.0 11 6.4 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF2443 PF10398.9 KOS21181.1 - 0.034 14.2 0.2 0.095 12.8 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) Helicase_C_2 PF13307.6 KOS21181.1 - 0.046 13.9 0.0 0.081 13.1 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain DUF5335 PF17269.2 KOS21181.1 - 0.068 13.0 0.2 0.12 12.2 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5335) FtsK_SpoIIIE PF01580.18 KOS21181.1 - 0.093 12.1 0.1 0.24 10.7 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Ribosomal_L13 PF00572.18 KOS21183.1 - 9.8e-41 138.9 0.0 1.4e-40 138.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 tRNA-synt_1c PF00749.21 KOS21184.1 - 1.3e-78 264.1 0.0 1.7e-78 263.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain TPR_1 PF00515.28 KOS21185.1 - 1.3e-16 59.7 8.6 6.4e-08 32.1 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS21185.1 - 2.6e-16 58.3 5.6 9.1e-06 25.4 0.0 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21185.1 - 3.6e-11 42.3 3.8 3.1e-05 23.8 0.0 4.9 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 KOS21185.1 - 8.7e-10 38.6 1.2 0.24 12.1 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat PB1 PF00564.24 KOS21185.1 - 5e-09 36.0 0.1 9.7e-09 35.1 0.1 1.4 1 0 0 1 1 1 1 PB1 domain TPR_12 PF13424.6 KOS21185.1 - 6.5e-09 36.0 2.5 6.7e-06 26.3 0.2 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOS21185.1 - 6.4e-08 32.1 2.0 1e-05 25.1 0.1 3.5 2 1 1 3 3 3 1 TPR repeat TPR_16 PF13432.6 KOS21185.1 - 7.5e-07 29.7 1.2 0.0005 20.7 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS21185.1 - 1.7e-06 27.7 5.7 1.4e-05 24.8 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS21185.1 - 3.6e-05 24.2 0.8 0.018 15.8 0.0 3.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS21185.1 - 4.3e-05 23.6 0.7 0.042 14.2 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS21185.1 - 0.00051 20.1 0.3 0.33 11.1 0.1 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TFIIA PF03153.13 KOS21185.1 - 0.00083 19.5 13.4 0.0011 19.1 13.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TPR_10 PF13374.6 KOS21185.1 - 0.0058 16.5 0.3 0.51 10.3 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOS21185.1 - 0.014 15.9 0.1 1e+02 4.0 0.0 4.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Spt20 PF12090.8 KOS21185.1 - 0.017 14.7 12.9 0.029 14.0 12.9 1.4 1 0 0 1 1 1 0 Spt20 family Med19 PF10278.9 KOS21185.1 - 0.033 14.1 4.7 0.068 13.1 4.7 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 ANAPC3 PF12895.7 KOS21185.1 - 0.091 13.0 0.5 4.7 7.5 0.1 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Phos_pyr_kin PF08543.12 KOS21186.1 - 1.5e-67 227.6 0.5 1.9e-67 227.2 0.5 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TENA_THI-4 PF03070.16 KOS21186.1 - 2.7e-34 118.8 0.2 9.5e-24 84.4 0.0 2.2 2 0 0 2 2 2 2 TENA/THI-4/PQQC family PfkB PF00294.24 KOS21186.1 - 0.00012 21.5 0.2 0.00084 18.7 0.0 2.2 2 1 0 2 2 2 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 KOS21186.1 - 0.089 12.2 1.3 0.14 11.6 1.3 1.4 1 0 0 1 1 1 0 Carbohydrate kinase Pyr_redox_2 PF07992.14 KOS21187.1 - 6.2e-53 179.9 0.1 7.8e-53 179.6 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 KOS21187.1 - 3e-12 46.9 0.0 9.6e-11 42.1 0.1 2.8 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS21187.1 - 0.00034 20.0 0.5 0.16 11.2 0.1 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase DHR10 PF18595.1 KOS21187.1 - 0.034 14.2 0.2 0.065 13.3 0.2 1.4 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain EcoR124_C PF12008.8 KOS21187.1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Type I restriction and modification enzyme - subunit R C terminal Uricase PF01014.18 KOS21188.1 - 1.2e-76 255.2 0.1 9.6e-42 142.3 0.1 2.0 2 0 0 2 2 2 2 Uricase RICTOR_N PF14664.6 KOS21189.1 - 5.4e-132 440.3 0.0 1.3e-131 439.0 0.0 1.7 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 KOS21189.1 - 5.2e-39 132.2 1.0 1.2e-35 121.4 0.1 4.7 3 1 2 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain RasGEF_N_2 PF14663.6 KOS21189.1 - 5.7e-37 126.4 0.1 5.1e-35 120.1 0.0 3.1 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_V PF14668.6 KOS21189.1 - 2.6e-29 101.3 0.3 6.6e-28 96.8 0.1 3.2 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 HR1 PF02185.16 KOS21189.1 - 6.9e-15 54.9 8.4 2.2e-14 53.3 8.4 1.9 1 0 0 1 1 1 1 Hr1 repeat Uds1 PF15456.6 KOS21189.1 - 0.13 12.5 5.7 0.3 11.2 5.7 1.7 1 0 0 1 1 1 0 Up-regulated During Septation Ribosomal_L36e PF01158.18 KOS21191.1 - 2.1e-42 143.3 6.5 2.3e-42 143.1 6.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e MRP-L28 PF09812.9 KOS21191.1 - 0.00063 19.9 1.8 0.00073 19.7 1.8 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 14-3-3 PF00244.20 KOS21192.1 - 7.9e-106 352.5 1.8 9.8e-106 352.2 1.8 1.1 1 0 0 1 1 1 1 14-3-3 protein Ima1_N PF09779.9 KOS21192.1 - 0.17 12.7 0.6 4.2 8.2 0.0 3.0 3 1 1 4 4 4 0 Ima1 N-terminal domain Lipase_3 PF01764.25 KOS21193.1 - 2.4e-28 98.8 0.0 3.1e-28 98.4 0.0 1.1 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 KOS21193.1 - 0.0023 17.2 0.0 0.0042 16.4 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KOS21193.1 - 0.0032 17.6 0.0 0.0047 17.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_1 PF00561.20 KOS21193.1 - 0.0056 16.4 0.0 0.0095 15.6 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF2974 PF11187.8 KOS21193.1 - 0.099 12.2 0.0 1.1 8.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 KOS21193.1 - 1.4 9.5 23.2 3.1 8.3 22.8 1.9 1 1 0 1 1 1 0 Alpha/beta hydrolase family Syja_N PF02383.18 KOS21194.1 - 7.7e-72 242.3 0.0 1.2e-71 241.7 0.0 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 KOS21194.1 - 8.9e-08 31.9 0.0 1.7e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4805 PF16063.5 KOS21195.1 - 0.077 12.3 3.7 0.11 11.8 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) peroxidase PF00141.23 KOS21196.1 - 2.3e-47 161.6 0.0 3.7e-47 160.9 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Suf PF05843.14 KOS21197.1 - 3.5e-06 27.2 5.7 0.00098 19.2 0.2 3.2 2 1 1 3 3 3 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 KOS21197.1 - 0.0009 19.9 12.3 0.012 16.4 0.0 6.0 7 2 2 9 9 9 2 Tetratricopeptide repeat TUG-UBL1 PF11470.8 KOS21198.1 - 1.3e-25 89.4 0.1 2.5e-25 88.5 0.1 1.5 1 0 0 1 1 1 1 TUG ubiquitin-like domain RBD PF02196.15 KOS21198.1 - 0.00016 21.7 0.3 0.00043 20.3 0.2 1.7 2 0 0 2 2 2 1 Raf-like Ras-binding domain DUF4294 PF14127.6 KOS21198.1 - 0.0018 18.2 0.0 0.0031 17.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4294) Rad60-SLD PF11976.8 KOS21198.1 - 0.096 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Mucin PF01456.17 KOS21198.1 - 0.14 12.2 1.5 0.22 11.5 1.5 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Proteasome PF00227.26 KOS21199.1 - 9.8e-44 149.1 0.0 1.1e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Thioredoxin PF00085.20 KOS21200.1 - 1.8e-22 79.3 0.0 2.1e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOS21200.1 - 4.6e-06 26.2 0.0 5.2e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 KOS21200.1 - 1.2e-05 25.7 0.0 0.00019 21.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOS21200.1 - 1.3e-05 25.0 0.0 1.6e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 KOS21200.1 - 0.0016 18.5 0.0 0.0022 18.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Glutaredoxin PF00462.24 KOS21200.1 - 0.0046 17.1 0.0 0.0092 16.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_8 PF13905.6 KOS21200.1 - 0.0049 17.2 0.0 0.042 14.2 0.0 2.0 1 1 1 2 2 2 2 Thioredoxin-like Redoxin PF08534.10 KOS21200.1 - 0.0089 15.8 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 KOS21200.1 - 0.037 13.9 0.0 0.082 12.8 0.0 1.5 1 1 1 2 2 2 0 AhpC/TSA family WD40 PF00400.32 KOS21201.1 - 4.1e-26 90.7 2.4 0.00019 22.2 0.0 7.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21201.1 - 1.1e-06 28.9 0.0 0.6 10.5 0.0 4.4 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS21201.1 - 0.00068 18.7 0.1 0.02 13.9 0.0 2.8 4 0 0 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 KOS21201.1 - 0.026 13.2 0.1 1.3 7.6 0.1 2.5 1 1 0 1 1 1 0 Nucleoporin Nup120/160 WD40_like PF17005.5 KOS21201.1 - 0.096 12.0 0.0 22 4.3 0.0 3.2 4 0 0 4 4 4 0 WD40-like domain AA_permease_2 PF13520.6 KOS21202.1 - 3.2e-60 204.1 41.5 4e-60 203.8 41.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS21202.1 - 1.1e-33 116.6 40.6 1.4e-33 116.3 40.6 1.0 1 0 0 1 1 1 1 Amino acid permease IBV_3C PF03620.13 KOS21202.1 - 0.086 13.3 4.8 3.2 8.3 0.2 3.1 2 0 0 2 2 2 0 IBV 3C protein WD40 PF00400.32 KOS21203.1 - 1.6e-16 60.4 7.8 4.9e-07 30.3 0.2 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat CAF1C_H4-bd PF12265.8 KOS21203.1 - 1.7e-14 53.8 0.1 2.3e-13 50.2 0.0 2.7 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex ANAPC4_WD40 PF12894.7 KOS21203.1 - 3.3e-08 33.7 0.8 0.00086 19.6 0.1 3.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 KOS21203.1 - 0.12 11.3 2.1 0.12 11.3 0.6 1.7 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Med19 PF10278.9 KOS21204.1 - 0.0084 16.1 4.8 0.0097 15.9 4.8 1.1 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 DUF612 PF04747.12 KOS21204.1 - 0.1 11.7 13.5 0.13 11.4 13.5 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF612 Sec62 PF03839.16 KOS21204.1 - 0.78 9.2 5.9 0.97 8.9 5.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 zf-RING_UBOX PF13445.6 KOS21205.1 - 0.0004 20.4 1.0 0.0011 19.0 1.0 1.7 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS21205.1 - 0.0036 17.2 3.5 0.0075 16.2 2.9 1.8 1 1 1 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 KOS21205.1 - 0.0057 16.5 3.7 0.013 15.3 0.3 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 KOS21205.1 - 0.01 15.6 0.5 0.01 15.6 0.5 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS21205.1 - 0.026 14.4 2.3 0.077 12.9 2.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Serglycin PF04360.12 KOS21205.1 - 0.068 13.1 0.3 0.068 13.1 0.3 1.7 2 0 0 2 2 2 0 Serglycin zf-C3HC4_3 PF13920.6 KOS21205.1 - 0.084 12.8 3.8 0.12 12.3 0.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOS21205.1 - 0.15 12.2 2.8 0.67 10.2 0.2 2.3 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 KOS21205.1 - 0.34 11.3 5.0 0.13 12.6 0.8 2.1 2 0 0 2 2 2 0 Ring finger domain FYVE PF01363.21 KOS21205.1 - 0.44 10.7 4.0 2.6 8.3 4.0 2.0 1 1 0 1 1 1 0 FYVE zinc finger Mut7-C PF01927.16 KOS21205.1 - 0.71 10.0 3.0 1.1 9.4 3.0 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain Ribosomal_60s PF00428.19 KOS21205.1 - 6.2 7.5 6.2 1.6 9.4 2.6 1.9 2 0 0 2 2 2 0 60s Acidic ribosomal protein eRF1_1 PF03463.15 KOS21206.1 - 4.2e-41 140.0 0.0 9.5e-41 138.8 0.0 1.6 2 0 0 2 2 2 1 eRF1 domain 1 eRF1_2 PF03464.15 KOS21206.1 - 8.5e-21 74.7 0.0 1.3e-20 74.1 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 KOS21206.1 - 6.8e-16 58.7 0.0 1.3e-15 57.8 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 Gluconate_2-dh3 PF13618.6 KOS21206.1 - 0.035 14.3 0.1 0.074 13.3 0.1 1.5 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 Aldo_ket_red PF00248.21 KOS21207.1 - 8.4e-28 97.4 0.0 3.2e-25 88.9 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family Prp19 PF08606.11 KOS21208.1 - 3.6e-31 106.9 2.3 7.9e-31 105.9 2.0 1.7 2 0 0 2 2 2 1 Prp19/Pso4-like ANAPC4_WD40 PF12894.7 KOS21208.1 - 7.3e-14 51.8 0.0 0.031 14.6 0.0 5.6 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS21208.1 - 2.1e-09 37.9 0.3 0.038 14.9 0.0 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 KOS21208.1 - 8.6e-06 25.1 0.0 0.00015 20.9 0.0 2.0 1 1 0 1 1 1 1 Coatomer WD associated region HPS3_N PF14761.6 KOS21208.1 - 0.0006 19.4 0.0 0.58 9.7 0.0 2.3 1 1 1 2 2 2 2 Hermansky-Pudlak syndrome 3 V_ATPase_I_N PF18670.1 KOS21208.1 - 0.0094 16.3 0.3 0.028 14.8 0.1 1.8 2 0 0 2 2 2 1 V-type ATPase subunit I, N-terminal domain DNA_gyraseA_C PF03989.13 KOS21208.1 - 0.11 12.0 0.5 2.9 7.4 0.0 3.1 3 0 0 3 3 3 0 DNA gyrase C-terminal domain, beta-propeller OHCU_decarbox PF09349.10 KOS21209.1 - 3.9e-41 141.1 0.0 4.5e-41 140.9 0.0 1.0 1 0 0 1 1 1 1 OHCU decarboxylase Di19_C PF14571.6 KOS21209.1 - 0.0011 19.4 0.1 0.0018 18.8 0.1 1.3 1 0 0 1 1 1 1 Stress-induced protein Di19, C-terminal DUF3659 PF12396.8 KOS21211.1 - 7.4e-109 355.7 53.1 3.8e-24 84.4 1.1 6.9 6 0 0 6 6 6 6 Protein of unknown function (DUF3659) RabGAP-TBC PF00566.18 KOS21212.1 - 9.9e-33 113.6 0.0 1.5e-32 113.1 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SBE2 PF17076.5 KOS21212.1 - 4.1e-07 28.7 1.0 6.4e-07 28.0 1.0 1.2 1 0 0 1 1 1 1 SBE2, cell-wall formation FA_desaturase PF00487.24 KOS21213.1 - 1.7e-24 87.1 21.0 4.6e-24 85.6 21.0 1.8 1 1 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 KOS21213.1 - 8.8e-08 32.4 0.0 8.9e-07 29.2 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3474) eIF2A PF08662.11 KOS21214.1 - 2.4e-37 128.7 0.7 1.2e-34 119.9 0.0 3.5 2 2 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 KOS21214.1 - 0.00017 21.4 0.0 0.00034 20.4 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 KOS21214.1 - 0.0092 16.8 2.1 6.3 7.8 0.0 4.5 3 1 1 4 4 4 1 WD domain, G-beta repeat PRP3 PF08572.10 KOS21214.1 - 0.062 13.0 0.2 0.14 11.9 0.0 1.7 2 0 0 2 2 2 0 pre-mRNA processing factor 3 (PRP3) Cpn60_TCP1 PF00118.24 KOS21215.1 - 1.9e-142 475.3 11.3 2.2e-142 475.2 11.3 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5442 PF17514.2 KOS21215.1 - 0.022 15.0 0.1 0.053 13.7 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5442) CRM1_repeat PF18777.1 KOS21215.1 - 0.099 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 Chromosome region maintenance or exportin repeat zf-C3HC4_3 PF13920.6 KOS21216.1 - 0.0012 18.6 10.2 0.0012 18.6 10.2 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 KOS21217.1 - 2.9e-42 144.9 0.0 4.2e-31 108.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Ribonuc_2-5A PF06479.12 KOS21217.1 - 2.7e-41 140.7 0.0 5.3e-41 139.8 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase_Tyr PF07714.17 KOS21217.1 - 8.6e-22 77.7 0.0 1.3e-18 67.2 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 KOS21217.1 - 0.0015 18.0 0.0 0.0026 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 KOS21217.1 - 0.0056 15.5 0.0 0.011 14.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS21217.1 - 0.022 14.7 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 KOS21217.1 - 0.029 13.9 0.0 0.3 10.6 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL PQQ PF01011.21 KOS21217.1 - 0.21 11.6 0.5 5.9 7.0 0.1 3.0 3 0 0 3 3 3 0 PQQ enzyme repeat PLDc_2 PF13091.6 KOS21218.1 - 1.9e-17 63.4 0.0 3.7e-11 43.0 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 KOS21218.1 - 0.0011 19.1 0.1 0.0083 16.3 0.0 2.2 2 0 0 2 2 2 1 Phospholipase D Active site motif Regulator_TrmB PF11495.8 KOS21218.1 - 0.0094 15.1 0.0 0.034 13.3 0.0 1.9 2 0 0 2 2 2 1 Archaeal transcriptional regulator TrmB FMO-like PF00743.19 KOS21218.1 - 0.05 12.0 0.0 0.074 11.5 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like SWIB PF02201.18 KOS21219.1 - 5.8e-24 83.8 0.2 1.5e-23 82.4 0.1 1.8 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 KOS21219.1 - 2.2e-17 62.7 1.6 4.3e-17 61.8 1.6 1.5 1 0 0 1 1 1 1 DEK C terminal domain FliT PF05400.13 KOS21219.1 - 0.0027 18.5 0.3 1.6 9.6 0.0 2.5 2 0 0 2 2 2 2 Flagellar protein FliT Methyltransf_PK PF05891.12 KOS21219.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase DTHCT PF08070.11 KOS21219.1 - 0.17 12.6 17.0 1.8 9.4 3.8 2.5 1 1 1 2 2 2 0 DTHCT (NUC029) region SRP-alpha_N PF04086.13 KOS21219.1 - 0.92 9.4 9.5 1.1 9.2 9.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TMEM119 PF15724.5 KOS21219.1 - 3.4 7.7 10.5 2.5 8.1 6.7 2.0 1 1 1 2 2 2 0 TMEM119 family Alpha_kinase PF02816.18 KOS21220.1 - 5.1e-39 134.3 0.0 6.2e-39 134.0 0.0 1.0 1 0 0 1 1 1 1 Alpha-kinase family APS_kinase PF01583.20 KOS21221.1 - 1.8e-72 242.4 0.0 2.1e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 KOS21221.1 - 6.1e-06 26.4 0.0 1.2e-05 25.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOS21221.1 - 4.8e-05 23.9 0.0 6.7e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 KOS21221.1 - 0.00045 19.8 0.0 0.00051 19.6 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_16 PF13191.6 KOS21221.1 - 0.0052 17.2 0.1 0.0078 16.6 0.1 1.3 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 KOS21221.1 - 0.026 13.8 0.0 0.045 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PRK PF00485.18 KOS21221.1 - 0.035 13.8 0.0 0.045 13.5 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family 6PF2K PF01591.18 KOS21221.1 - 0.059 12.7 0.0 0.088 12.1 0.0 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase CPT PF07931.12 KOS21221.1 - 0.088 12.6 0.1 0.18 11.6 0.1 1.9 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.6 KOS21221.1 - 0.089 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF463 PF04317.12 KOS21221.1 - 0.092 11.7 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 YcjX-like family, DUF463 ADH_zinc_N_2 PF13602.6 KOS21222.1 - 2.3e-11 44.9 0.0 4e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOS21222.1 - 3.3e-09 36.8 0.0 5.3e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOS21222.1 - 8.9e-05 22.3 0.0 0.00036 20.4 0.0 2.1 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Glyco_hydro_18 PF00704.28 KOS21223.1 - 1.4e-54 186.0 0.0 2e-54 185.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 MFS_1 PF07690.16 KOS21224.1 - 1.9e-11 43.5 26.9 7.7e-10 38.2 14.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Aldo_ket_red PF00248.21 KOS21225.1 - 4.5e-48 163.9 0.0 5.1e-48 163.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family UPF0261 PF06792.11 KOS21226.1 - 1.7e-159 531.2 0.0 1.9e-159 531.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0261) PEP_hydrolase PF09370.10 KOS21227.1 - 1.2e-126 421.4 0.6 1.3e-126 421.2 0.6 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate hydrolase-like NMO PF03060.15 KOS21227.1 - 8.9e-06 25.3 2.8 1.5e-05 24.6 0.2 1.9 2 0 0 2 2 2 1 Nitronate monooxygenase WSC PF01822.19 KOS21228.1 - 2e-05 24.7 0.1 3e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 WSC domain Glyco_hydro_3_C PF01915.22 KOS21229.1 - 9.2e-43 146.6 0.0 1.3e-42 146.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS21229.1 - 4.9e-35 121.4 0.0 7.6e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS21229.1 - 2.6e-06 27.4 0.0 5.2e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF4334 PF14232.6 KOS21230.1 - 3.9e-25 87.6 0.1 8e-24 83.4 0.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4334) GXWXG PF14231.6 KOS21230.1 - 6.4e-15 55.0 0.2 1.2e-14 54.1 0.2 1.5 1 0 0 1 1 1 1 GXWXG protein F-box PF00646.33 KOS21231.1 - 0.0084 16.0 0.1 0.034 14.0 0.1 2.1 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS21231.1 - 0.025 14.4 0.2 0.058 13.3 0.2 1.6 1 0 0 1 1 1 0 F-box-like SDA1 PF05285.12 KOS21231.1 - 0.074 12.5 15.1 0.11 12.0 15.1 1.1 1 0 0 1 1 1 0 SDA1 RSN1_7TM PF02714.15 KOS21232.1 - 4.4e-73 246.0 25.1 4.4e-73 246.0 25.1 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 KOS21232.1 - 2.3e-37 128.2 1.5 2.3e-37 128.2 1.5 2.4 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 KOS21232.1 - 7.5e-32 111.0 0.0 1.1e-31 110.4 0.0 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter TFIIA PF03153.13 KOS21234.1 - 1.6e-08 35.0 46.2 9.3e-06 25.9 3.9 3.3 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Zn_clus PF00172.18 KOS21234.1 - 5.1e-07 29.7 11.9 7.9e-07 29.1 11.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TMEM171 PF15471.6 KOS21234.1 - 2.1 7.2 4.4 5.9 5.8 4.4 1.7 1 0 0 1 1 1 0 Transmembrane protein family 171 DUF3439 PF11921.8 KOS21234.1 - 3.4 7.7 8.0 0.23 11.4 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) MecA PF05389.12 KOS21234.1 - 6.2 6.4 7.4 1.9 8.1 0.4 2.3 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) YEATS PF03366.16 KOS21235.1 - 9.8e-20 70.3 0.0 2e-19 69.4 0.0 1.5 1 0 0 1 1 1 1 YEATS family BET PF17035.5 KOS21235.1 - 3.9e-05 23.7 0.4 0.0001 22.4 0.4 1.7 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Ran_BP1 PF00638.18 KOS21236.1 - 4.4e-44 149.7 1.8 4.4e-44 149.7 1.8 1.8 2 0 0 2 2 2 1 RanBP1 domain Apolipoprotein PF01442.18 KOS21237.1 - 0.00078 19.4 8.7 0.0014 18.5 8.7 1.4 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 KOS21237.1 - 0.067 13.2 0.8 0.15 12.1 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 KOS21237.1 - 1.3 9.7 11.0 3 8.5 0.3 3.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) CDC45 PF02724.14 KOS21237.1 - 1.6 6.9 6.6 2.4 6.3 6.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Med13_C PF06333.12 KOS21237.1 - 3.4 6.8 8.9 0.053 12.8 1.3 1.8 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain Phosducin PF02114.16 KOS21238.1 - 8.6e-13 47.8 0.0 1.3e-12 47.2 0.0 1.2 1 0 0 1 1 1 1 Phosducin YL1 PF05764.13 KOS21238.1 - 0.0096 16.1 2.7 0.0096 16.1 2.7 2.1 2 0 0 2 2 2 1 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 KOS21238.1 - 0.01 15.6 1.7 0.01 15.6 1.7 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Citrate_bind PF16114.5 KOS21238.1 - 0.16 11.4 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 ATP citrate lyase citrate-binding Serglycin PF04360.12 KOS21238.1 - 0.22 11.5 2.9 0.43 10.5 2.9 1.5 1 0 0 1 1 1 0 Serglycin DUF3246 PF11596.8 KOS21238.1 - 0.38 10.1 5.0 2.3 7.6 1.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) Sporozoite_P67 PF05642.11 KOS21238.1 - 3.6 5.6 5.3 2.5 6.1 0.7 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Prothymosin PF03247.14 KOS21238.1 - 5 7.6 18.6 0.26 11.8 4.7 2.2 2 0 0 2 2 2 0 Prothymosin/parathymosin family EAP30 PF04157.16 KOS21239.1 - 1.7e-64 217.4 0.0 2.7e-64 216.7 0.0 1.3 1 1 0 1 1 1 1 EAP30/Vps36 family DnaJ_C PF01556.18 KOS21240.1 - 3.3e-34 118.1 0.0 5.2e-34 117.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOS21240.1 - 2.4e-23 82.0 3.2 4.3e-23 81.2 3.2 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOS21240.1 - 9.8e-13 48.3 17.2 1.8e-12 47.4 17.2 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 KOS21240.1 - 0.027 14.4 10.8 0.36 10.8 0.6 2.4 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 KOS21240.1 - 0.7 9.9 7.6 5.3 7.1 1.4 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 KOS21240.1 - 8.8 6.6 12.5 1.7 8.8 2.4 2.3 1 1 1 2 2 2 0 zinc RING finger of MSL2 Glyco_transf_64 PF09258.10 KOS21241.1 - 2e-53 181.2 0.0 2.8e-53 180.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Glyco_tranf_2_3 PF13641.6 KOS21241.1 - 0.00022 21.2 0.0 0.0003 20.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KOS21241.1 - 0.015 15.2 0.1 0.11 12.3 0.1 2.2 1 1 0 1 1 1 0 Glycosyl transferase family 2 CHZ PF09649.10 KOS21242.1 - 0.0082 15.6 0.2 0.015 14.7 0.2 1.4 1 0 0 1 1 1 1 Histone chaperone domain CHZ DUF3659 PF12396.8 KOS21243.1 - 4.1e-19 68.3 1.5 3e-12 46.3 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF3659) UPF0051 PF01458.17 KOS21243.1 - 0.092 12.4 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein family (UPF0051) Nha1_C PF08619.10 KOS21244.1 - 0.0034 16.7 0.6 0.0034 16.7 0.6 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus LZ_Tnp_IS481 PF13011.6 KOS21244.1 - 1.3 9.6 5.3 2.2 8.8 5.3 1.3 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 WD40 PF00400.32 KOS21246.1 - 6.2e-59 194.6 40.8 2.7e-11 43.8 1.8 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21246.1 - 1.9e-22 79.3 7.1 0.00038 20.7 0.9 6.6 2 2 3 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS21246.1 - 2.6e-06 26.7 0.1 1.7 7.5 0.0 5.2 3 3 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 KOS21246.1 - 5.1e-06 26.3 0.2 0.24 11.4 0.0 4.0 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 KOS21246.1 - 7.8e-06 24.8 1.9 0.38 9.3 0.0 5.1 3 2 2 6 6 6 1 Nucleoporin Nup120/160 eIF2A PF08662.11 KOS21246.1 - 1.8e-05 24.7 0.3 0.059 13.2 0.0 3.5 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.12 KOS21246.1 - 0.0037 17.8 0.0 0.0095 16.4 0.0 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain WD40_like PF17005.5 KOS21246.1 - 0.0067 15.8 0.0 3.9 6.7 0.0 3.4 4 0 0 4 4 4 1 WD40-like domain Proteasome_A_N PF10584.9 KOS21246.1 - 0.036 13.8 0.8 5.5 6.8 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ASH PF15780.5 KOS21246.1 - 0.073 13.3 0.1 4.2 7.7 0.0 2.9 3 0 0 3 3 3 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DASH_Spc19 PF08287.11 KOS21247.1 - 2.4e-48 164.0 2.5 3.3e-48 163.5 2.5 1.2 1 0 0 1 1 1 1 Spc19 PCI PF01399.27 KOS21248.1 - 8.6e-23 80.9 0.0 3.6e-22 78.9 0.0 2.1 1 0 0 1 1 1 1 PCI domain RPN5_C PF18098.1 KOS21248.1 - 4.9e-16 58.5 2.6 1.3e-15 57.2 2.6 1.8 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain Cas_DxTHG PF09455.10 KOS21248.1 - 0.7 9.4 5.9 0.19 11.3 2.9 1.6 2 0 0 2 2 2 0 CRISPR-associated (Cas) DxTHG family CTD PF12815.7 KOS21249.1 - 0.068 13.7 28.8 1.8 9.2 7.7 3.0 1 1 2 3 3 3 0 Spt5 C-terminal nonapeptide repeat binding Spt4 SH3_1 PF00018.28 KOS21250.1 - 2.2e-09 36.8 0.1 4.1e-09 35.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS21250.1 - 1.1e-06 28.4 0.0 1.9e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOS21250.1 - 2e-06 27.4 0.0 4.6e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain PsbW PF07123.12 KOS21250.1 - 0.5 10.4 0.1 0.5 10.4 0.1 2.0 2 0 0 2 2 2 0 Photosystem II reaction centre W protein (PsbW) DUF1129 PF06570.11 KOS21250.1 - 1.6 8.2 5.1 1.7 8.1 4.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) Thioredoxin PF00085.20 KOS21251.1 - 4.6e-27 94.0 0.2 7.7e-27 93.3 0.0 1.4 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 KOS21251.1 - 7.8e-06 26.1 0.0 1.1e-05 25.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 KOS21251.1 - 2e-05 24.1 0.0 2.9e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 KOS21251.1 - 0.0001 22.2 0.0 0.00014 21.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 KOS21251.1 - 0.00023 21.6 0.1 0.00055 20.4 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 KOS21251.1 - 0.0007 19.4 0.0 0.00099 18.9 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 KOS21251.1 - 0.0054 16.4 0.1 0.0081 15.9 0.1 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.6 KOS21251.1 - 0.033 14.4 0.0 0.056 13.6 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Rsm22 PF09243.10 KOS21252.1 - 6.6e-34 117.4 0.0 6.1e-33 114.3 0.0 2.3 1 1 0 1 1 1 1 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_25 PF13649.6 KOS21252.1 - 0.12 13.0 0.0 0.57 10.9 0.0 2.1 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOS21252.1 - 0.23 12.2 0.5 0.83 10.4 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 KOS21253.1 - 8.6e-17 61.2 5.1 0.023 15.5 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21253.1 - 2e-06 28.0 0.3 3.1 8.2 0.1 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain MMS1_N PF10433.9 KOS21253.1 - 0.24 10.0 0.0 0.39 9.3 0.0 1.3 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term Methyltrn_RNA_3 PF02598.17 KOS21254.1 - 3e-101 338.7 0.0 3.4e-101 338.5 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase AAA_29 PF13555.6 KOS21254.1 - 0.027 14.2 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SCO1-SenC PF02630.14 KOS21255.1 - 4.9e-48 162.4 0.0 6.8e-48 162.0 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Redoxin PF08534.10 KOS21255.1 - 0.014 15.1 0.0 0.27 10.9 0.0 2.2 1 1 0 1 1 1 0 Redoxin AhpC-TSA PF00578.21 KOS21255.1 - 0.022 14.7 0.0 0.051 13.5 0.0 1.7 1 1 0 1 1 1 0 AhpC/TSA family Phage_holin_3_3 PF16083.5 KOS21255.1 - 0.2 11.8 0.0 0.35 11.0 0.0 1.4 1 0 0 1 1 1 0 LydA holin phage, holin superfamily III PHD PF00628.29 KOS21256.1 - 9.7e-11 41.4 11.9 2e-10 40.4 11.9 1.6 1 0 0 1 1 1 1 PHD-finger HMA PF00403.26 KOS21257.1 - 1.2e-09 38.5 0.0 1.9e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Heavy-metal-associated domain Sod_Cu PF00080.20 KOS21257.1 - 5.9e-08 33.0 0.0 1e-07 32.2 0.0 1.3 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Serglycin PF04360.12 KOS21257.1 - 0.039 13.9 2.7 0.068 13.1 2.7 1.3 1 0 0 1 1 1 0 Serglycin CTD PF12815.7 KOS21258.1 - 0.2 12.2 0.0 0.27 11.8 0.0 1.2 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 SseC PF04888.12 KOS21259.1 - 0.0002 21.0 20.0 0.0002 21.0 20.0 2.0 2 1 0 2 2 2 1 Secretion system effector C (SseC) like family Host_attach PF10116.9 KOS21259.1 - 0.12 13.0 6.1 0.26 11.9 6.1 1.6 1 0 0 1 1 1 0 Protein required for attachment to host cells YtxH PF12732.7 KOS21259.1 - 0.12 12.9 18.7 29 5.3 0.0 3.8 2 1 0 2 2 2 0 YtxH-like protein HTH_42 PF06224.12 KOS21259.1 - 0.12 11.8 1.4 0.17 11.4 1.4 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MgtE_N PF03448.17 KOS21259.1 - 0.24 12.0 8.2 0.48 11.1 8.2 1.6 1 0 0 1 1 1 0 MgtE intracellular N domain HK97-gp10_like PF04883.12 KOS21259.1 - 0.41 11.7 19.7 0.71 10.9 3.2 3.3 1 1 1 2 2 2 0 Bacteriophage HK97-gp10, putative tail-component Antimicrobial_2 PF08023.12 KOS21259.1 - 0.48 11.0 5.1 4.3e+02 1.6 5.1 4.0 1 1 0 1 1 1 0 Frog antimicrobial peptide VPS38 PF17649.1 KOS21259.1 - 0.49 9.2 8.6 0.86 8.4 8.6 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 38 DUF4294 PF14127.6 KOS21259.1 - 0.81 9.6 10.4 6.2 6.7 7.6 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4294) Cu PF17563.2 KOS21259.1 - 0.86 9.9 8.1 7.8e+02 0.4 8.1 3.6 1 1 0 1 1 1 0 Cupiennin CID_GANP PF16766.5 KOS21259.1 - 1 9.6 11.2 63 3.9 9.0 2.9 2 1 0 2 2 1 0 Binding region of GANP to ENY2 REF PF05755.12 KOS21259.1 - 1.1 9.1 11.8 0.9 9.3 4.5 2.3 1 1 1 2 2 2 0 Rubber elongation factor protein (REF) EnY2 PF10163.9 KOS21259.1 - 2 8.8 8.4 3.6 8.0 7.3 2.0 1 1 0 1 1 1 0 Transcription factor e(y)2 Grg1 PF11034.8 KOS21259.1 - 2.1 8.6 19.1 16 5.8 4.7 3.5 1 1 1 2 2 2 0 Glucose-repressible protein Grg1 DUF445 PF04286.12 KOS21259.1 - 2.3 7.9 15.5 2.2 8.0 14.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) TetR_C_19 PF17924.1 KOS21259.1 - 2.6 8.7 8.3 7.5 7.2 7.7 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain ATC_hydrolase PF14196.6 KOS21259.1 - 2.7 8.8 16.0 7.8 7.3 16.0 1.9 1 1 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase CBFD_NFYB_HMF PF00808.23 KOS21259.1 - 2.9 8.3 17.9 1.4 9.3 4.2 3.1 2 1 1 3 3 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone hDGE_amylase PF14701.6 KOS21259.1 - 5.5 6.0 8.9 9 5.3 8.9 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain RapA_C PF12137.8 KOS21259.1 - 5.6 5.9 18.4 1.3 8.0 12.3 2.1 1 1 1 2 2 2 0 RNA polymerase recycling family C-terminal SICA_alpha PF12887.7 KOS21259.1 - 5.6 6.8 11.9 15 5.4 9.1 2.3 1 1 1 2 2 2 0 SICA extracellular alpha domain Tam41_Mmp37 PF09139.11 KOS21259.1 - 6.1 6.2 9.6 12 5.2 9.6 1.6 1 1 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial ADSL_C PF10397.9 KOS21259.1 - 7.3 7.2 13.5 1.6e+03 -0.3 13.5 2.8 1 1 0 1 1 1 0 Adenylosuccinate lyase C-terminus CelTOS PF18659.1 KOS21259.1 - 8.6 6.8 9.0 5.3 7.5 5.6 2.4 2 1 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Spore_II_R PF09551.10 KOS21259.1 - 9.3 6.7 12.0 12 6.3 9.1 2.5 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) HgmA PF04209.13 KOS21261.1 - 1.8e-185 616.7 0.0 2e-185 616.5 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Snurportin1 PF11538.8 KOS21263.1 - 0.096 12.9 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 Snurportin1 BRE PF06113.12 KOS21265.1 - 0.17 10.7 0.0 0.62 8.8 0.0 1.7 2 0 0 2 2 2 0 Brain and reproductive organ-expressed protein (BRE) ABC2_membrane PF01061.24 KOS21266.1 - 1.1e-75 253.7 64.8 7.9e-41 139.8 19.4 3.6 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 KOS21266.1 - 7.3e-29 99.5 9.4 1.5e-26 92.1 0.0 3.5 3 0 0 3 3 2 2 CDR ABC transporter ABC_tran PF00005.27 KOS21266.1 - 1.4e-12 48.3 0.0 3.1e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 KOS21266.1 - 0.00013 22.4 0.0 0.00034 21.0 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.6 KOS21266.1 - 0.00039 20.0 0.0 0.00075 19.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 KOS21266.1 - 0.00052 19.9 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase ABC2_membrane_3 PF12698.7 KOS21266.1 - 0.0021 17.3 18.6 0.0021 17.3 18.6 4.6 2 2 2 4 4 4 2 ABC-2 family transporter protein AAA_18 PF13238.6 KOS21266.1 - 0.0065 17.0 0.0 0.013 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOS21266.1 - 0.0092 16.1 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_21 PF13304.6 KOS21266.1 - 0.016 15.0 0.0 0.73 9.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 KOS21266.1 - 0.017 14.8 0.1 0.043 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 KOS21266.1 - 0.024 14.1 0.0 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_17 PF13207.6 KOS21266.1 - 0.068 13.6 0.0 0.24 11.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 KOS21266.1 - 0.087 12.4 0.1 0.2 11.2 0.1 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Pkinase PF00069.25 KOS21267.1 - 3.6e-63 213.4 0.0 4.1e-63 213.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21267.1 - 1.2e-34 119.7 0.0 1.8e-34 119.2 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS21267.1 - 1.8e-06 27.5 0.0 2.8e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOS21267.1 - 0.00035 19.5 0.0 0.0005 19.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 KOS21267.1 - 0.11 12.1 0.0 4.1 7.0 0.0 2.1 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOS21267.1 - 0.2 11.6 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DEAD PF00270.29 KOS21268.1 - 2e-40 138.4 0.0 5.2e-40 137.1 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS21268.1 - 7.8e-30 103.5 0.1 1.8e-29 102.3 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS21268.1 - 7e-05 22.9 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 KOS21268.1 - 0.0074 15.0 0.0 0.01 14.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DNA_pol_phi PF04931.13 KOS21268.1 - 0.22 9.6 23.7 0.33 9.0 23.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 KOS21268.1 - 0.29 9.3 16.6 0.47 8.6 16.6 1.2 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 KOS21268.1 - 1.2 8.8 28.7 2.1 8.0 28.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RPN2_C PF18004.1 KOS21268.1 - 3.7 7.4 9.2 0.18 11.7 3.5 1.6 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain BUD22 PF09073.10 KOS21268.1 - 4.4 6.5 17.8 7 5.9 17.8 1.2 1 0 0 1 1 1 0 BUD22 Nucleo_P87 PF07267.11 KOS21268.1 - 4.8 5.9 12.1 7.4 5.3 12.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 IFT57 PF10498.9 KOS21268.1 - 6 5.7 7.7 9.4 5.1 7.7 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF2722 PF10846.8 KOS21268.1 - 8.7 5.2 13.9 12 4.7 13.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SAD_SRA PF02182.17 KOS21269.1 - 6e-07 29.3 0.1 1.4e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 SAD/SRA domain TruD PF01142.18 KOS21270.1 - 6.5e-56 189.9 0.0 1.3e-52 179.1 0.0 2.2 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) MarR_2 PF12802.7 KOS21270.1 - 0.11 12.4 0.0 9.1 6.3 0.0 2.6 2 0 0 2 2 2 0 MarR family RE_AspBHI_N PF18062.1 KOS21270.1 - 0.17 11.4 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease AspBHI N-terminal Ribosomal_L7Ae PF01248.26 KOS21271.1 - 3.2e-29 100.5 1.0 4.2e-29 100.1 1.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PucR PF07905.11 KOS21271.1 - 0.06 13.6 0.1 0.1 12.9 0.1 1.5 1 1 0 1 1 1 0 Purine catabolism regulatory protein-like family PELOTA_1 PF15608.6 KOS21271.1 - 0.077 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain Rotamase_3 PF13616.6 KOS21272.1 - 8e-18 65.1 0.1 1.5e-17 64.2 0.1 1.5 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 KOS21272.1 - 1.6e-15 57.8 0.0 2.5e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOS21272.1 - 8.7e-05 23.3 0.0 0.00011 23.0 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Glyco_transf_90 PF05686.12 KOS21273.1 - 3.2e-11 42.8 8.4 6.9e-06 25.2 0.1 4.1 3 2 0 3 3 3 3 Glycosyl transferase family 90 Ribosomal_S8 PF00410.19 KOS21274.1 - 4.5e-22 78.4 0.0 6e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 DUF1211 PF06736.11 KOS21275.1 - 0.16 12.4 0.0 8.3 6.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1211) ING PF12998.7 KOS21275.1 - 0.48 11.0 6.1 0.2 12.3 0.4 3.0 2 1 2 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding DUF3487 PF11990.8 KOS21275.1 - 1.9 8.4 4.7 4.1 7.3 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3487) Mod_r PF07200.13 KOS21275.1 - 2.4 8.2 12.2 0.15 12.1 1.3 3.0 3 0 0 3 3 3 0 Modifier of rudimentary (Mod(r)) protein BLOC1_2 PF10046.9 KOS21276.1 - 0.023 15.0 0.2 3.3 8.1 0.1 2.8 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sec2p PF06428.11 KOS21276.1 - 0.098 12.6 0.3 2.6 8.1 0.0 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p FlxA PF14282.6 KOS21276.1 - 0.34 10.9 0.1 0.34 10.9 0.1 2.4 3 0 0 3 3 3 0 FlxA-like protein Proteasome PF00227.26 KOS21277.1 - 3.1e-48 163.8 0.1 3.7e-48 163.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOS21277.1 - 0.00058 19.5 0.1 0.0011 18.6 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Asp PF00026.23 KOS21279.1 - 2.2e-54 185.0 0.2 5e-54 183.8 0.1 1.6 2 0 0 2 2 2 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS21279.1 - 5.9e-08 33.1 0.3 1.2e-06 28.9 0.0 2.7 1 1 1 2 2 2 1 Xylanase inhibitor N-terminal Vps36-NZF-N PF16988.5 KOS21279.1 - 0.6 9.5 4.1 1.2 8.6 0.6 2.6 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Zn_clus PF00172.18 KOS21280.1 - 2.8e-07 30.5 6.9 5.3e-07 29.7 6.9 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUIM_assoc PF16619.5 KOS21280.1 - 0.00075 19.5 9.3 0.0019 18.2 9.3 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 KOS21280.1 - 0.004 16.8 8.2 0.0061 16.2 8.2 1.3 1 0 0 1 1 1 1 Spt20 family HAD_2 PF13419.6 KOS21281.1 - 1.2e-21 77.6 0.0 1.6e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS21281.1 - 1e-08 35.7 0.1 2.8e-08 34.3 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase NIF PF03031.18 KOS21281.1 - 1e-06 28.6 0.0 0.00043 20.1 0.0 2.1 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase Hydrolase_like PF13242.6 KOS21281.1 - 8.9e-06 25.7 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 KOS21281.1 - 0.052 13.9 0.0 0.067 13.6 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NAPRTase_C PF17956.1 KOS21282.1 - 0.071 13.5 0.0 0.26 11.7 0.0 1.9 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase C-terminal domain Nop16 PF09420.10 KOS21284.1 - 7.3e-66 222.2 5.2 8.4e-66 222.0 5.2 1.0 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 MARVEL PF01284.23 KOS21285.1 - 0.0097 15.9 13.5 0.026 14.5 13.5 1.7 1 1 0 1 1 1 1 Membrane-associating domain DUF4281 PF14108.6 KOS21285.1 - 0.038 14.4 1.0 0.061 13.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4281) MFS_1 PF07690.16 KOS21286.1 - 4.4e-44 150.9 47.1 4.4e-44 150.9 47.1 1.8 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS21286.1 - 5.5e-19 68.4 28.6 8.9e-14 51.2 11.1 2.5 2 1 0 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 KOS21286.1 - 0.0014 17.6 16.8 0.047 12.5 8.6 2.5 2 1 0 2 2 2 2 MFS_1 like family DHDPS PF00701.22 KOS21287.1 - 1.1e-34 119.5 0.0 1.3e-34 119.2 0.0 1.0 1 0 0 1 1 1 1 Dihydrodipicolinate synthetase family Antimicrobial_1 PF08018.11 KOS21287.1 - 0.1 12.8 0.2 0.34 11.1 0.2 2.0 1 0 0 1 1 1 0 Frog antimicrobial peptide DnaJ_C PF01556.18 KOS21288.1 - 5.5e-39 133.6 1.4 7.3e-39 133.2 1.4 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOS21288.1 - 4.4e-27 94.0 5.2 7.2e-27 93.3 5.2 1.4 1 0 0 1 1 1 1 DnaJ domain NACHT_N PF17100.5 KOS21289.1 - 1.1e-21 77.7 11.2 2e-20 73.6 0.2 3.5 3 0 0 3 3 3 2 N-terminal domain of NWD NACHT-NTPase AAA_16 PF13191.6 KOS21289.1 - 1e-06 29.2 0.1 1e-06 29.2 0.1 3.4 4 0 0 4 4 4 1 AAA ATPase domain NACHT PF05729.12 KOS21289.1 - 7.7e-06 25.9 0.1 2.4e-05 24.3 0.1 1.9 1 1 0 1 1 1 1 NACHT domain AAA PF00004.29 KOS21289.1 - 0.00068 20.1 0.5 0.026 15.0 0.0 3.2 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS21289.1 - 0.002 18.4 0.1 0.014 15.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain eIF3_subunit PF08597.10 KOS21289.1 - 0.0034 17.3 15.9 0.0034 17.3 15.9 1.9 2 0 0 2 2 1 1 Translation initiation factor eIF3 subunit KAP_NTPase PF07693.14 KOS21289.1 - 0.043 13.1 2.9 0.15 11.3 0.0 2.8 2 1 0 3 3 2 0 KAP family P-loop domain SAPS PF04499.15 KOS21289.1 - 0.16 10.8 9.5 0.2 10.4 6.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 KOS21289.1 - 0.23 10.8 21.6 0.44 9.8 21.6 1.4 1 0 0 1 1 1 0 BUD22 Viral_helicase1 PF01443.18 KOS21289.1 - 1.5 8.5 0.0 1.5 8.5 0.0 2.8 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase RR_TM4-6 PF06459.12 KOS21289.1 - 2.6 7.8 22.5 5.7 6.7 22.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 KOS21289.1 - 2.9 8.0 9.0 0.17 12.0 3.3 1.8 2 0 0 2 2 2 0 DDHD domain DUF913 PF06025.12 KOS21289.1 - 5.6 5.8 14.4 9.4 5.1 10.9 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF775 PF05603.12 KOS21289.1 - 6 6.3 6.5 12 5.4 6.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) Zip PF02535.22 KOS21289.1 - 7 5.8 8.7 12 4.9 8.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Prothymosin PF03247.14 KOS21289.1 - 7.2 7.1 41.9 15 6.1 41.9 1.4 1 0 0 1 1 1 0 Prothymosin/parathymosin family GSHPx PF00255.19 KOS21290.1 - 1.5e-35 121.0 0.0 1.9e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 KOS21290.1 - 0.0025 17.7 0.1 0.0058 16.6 0.1 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOS21290.1 - 0.11 12.3 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Redoxin DAO PF01266.24 KOS21291.1 - 4.9e-68 230.3 4.0 5.9e-68 230.0 4.0 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS21291.1 - 0.0038 17.4 0.3 0.014 15.6 0.3 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain GMC_oxred_N PF00732.19 KOS21291.1 - 0.058 12.8 0.2 1.7 8.0 0.1 2.1 2 0 0 2 2 2 0 GMC oxidoreductase Mqo PF06039.15 KOS21291.1 - 0.073 11.6 0.0 2.7 6.5 0.0 2.0 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Pyr_redox PF00070.27 KOS21291.1 - 0.13 12.9 0.1 9.1 6.9 0.0 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GDA1_CD39 PF01150.17 KOS21292.1 - 6.4e-102 341.4 0.0 7.7e-102 341.1 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family AAA_lid_2 PF17863.1 KOS21293.1 - 7.6e-06 25.7 1.6 7.6e-06 25.7 1.6 1.9 2 0 0 2 2 2 1 AAA lid domain Ndc1_Nup PF09531.10 KOS21293.1 - 0.12 11.0 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ORC4_C PF14629.6 KOS21293.1 - 0.18 11.2 0.5 0.32 10.3 0.5 1.4 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 4 C-terminus SelP_N PF04592.14 KOS21293.1 - 1.1 8.6 13.7 1.8 7.9 13.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region HGTP_anticodon2 PF12745.7 KOS21294.1 - 2.1e-80 270.0 0.5 2.1e-80 270.0 0.5 2.4 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 KOS21294.1 - 4.1e-72 242.7 0.0 5.1e-35 121.1 0.0 3.7 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21294.1 - 1.4e-43 149.0 0.0 5.2e-19 68.5 0.0 3.5 3 0 0 3 3 3 3 Protein tyrosine kinase tRNA-synt_His PF13393.6 KOS21294.1 - 3.3e-14 52.9 0.0 3.3e-14 52.9 0.0 2.6 2 1 0 2 2 2 1 Histidyl-tRNA synthetase RWD PF05773.22 KOS21294.1 - 6.6e-10 39.3 0.0 1.8e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 RWD domain APH PF01636.23 KOS21294.1 - 1.8e-06 28.1 3.8 0.076 12.9 0.0 3.3 3 0 0 3 3 3 2 Phosphotransferase enzyme family ISG65-75 PF11727.8 KOS21294.1 - 0.28 10.4 7.3 0.67 9.1 7.3 1.6 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF1682 PF07946.14 KOS21294.1 - 0.51 9.5 9.6 0.83 8.8 9.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Rit1_C PF17184.4 KOS21295.1 - 1.3e-99 333.0 0.0 2.1e-99 332.4 0.0 1.3 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 KOS21295.1 - 6.7e-33 113.3 0.0 1.3e-32 112.3 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain GFO_IDH_MocA PF01408.22 KOS21295.1 - 1.3e-09 38.9 0.3 6.2e-09 36.7 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold Sec16_C PF12931.7 KOS21296.1 - 1.3e-109 366.5 0.0 1.7e-109 366.1 0.0 1.1 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16 PF12932.7 KOS21296.1 - 3.9e-34 117.8 0.0 8.9e-34 116.6 0.0 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Tachylectin PF14517.6 KOS21296.1 - 0.047 13.2 0.1 0.079 12.5 0.1 1.2 1 0 0 1 1 1 0 Tachylectin Suc_Fer-like PF06999.12 KOS21297.1 - 3.6e-26 92.2 0.0 4.9e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Aa_trans PF01490.18 KOS21298.1 - 8.9e-84 281.6 30.3 1.1e-83 281.3 30.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF4044 PF13253.6 KOS21298.1 - 0.89 9.1 8.9 0.11 12.1 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4044) PhoLip_ATPase_C PF16212.5 KOS21299.1 - 1.6e-46 159.1 2.7 1.6e-46 159.1 2.7 1.8 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 KOS21299.1 - 3e-16 58.8 0.7 6.1e-16 57.9 0.7 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 KOS21299.1 - 2.7e-14 54.0 0.3 4.7e-11 43.4 0.3 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOS21299.1 - 1e-08 34.9 1.5 0.00017 21.2 0.1 2.7 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase PF13246.6 KOS21299.1 - 4e-05 23.6 0.0 0.00054 20.0 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 KOS21299.1 - 0.0025 17.6 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase NAD_binding_1 PF00175.21 KOS21300.1 - 9.7e-05 23.0 0.0 0.00019 22.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOS21300.1 - 0.0013 19.1 0.0 0.015 15.7 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 KOS21300.1 - 0.16 12.1 0.0 0.23 11.6 0.0 1.2 1 0 0 1 1 1 0 Ferric reductase NAD binding domain Acyl-CoA_dh_1 PF00441.24 KOS21301.1 - 2.9e-27 95.7 1.3 4.9e-27 95.0 1.3 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 KOS21301.1 - 6.4e-20 71.2 0.0 1.1e-19 70.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 KOS21301.1 - 2.6e-15 57.1 0.0 5.3e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 KOS21301.1 - 9.5e-11 42.1 1.3 1.8e-10 41.2 1.3 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Ras PF00071.22 KOS21302.1 - 9.4e-57 191.1 0.0 1.1e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS21302.1 - 4.4e-32 110.8 0.0 6.2e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS21302.1 - 4.2e-13 49.1 0.0 4.9e-13 48.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS21302.1 - 5e-08 33.0 0.0 7.9e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS21302.1 - 5e-07 29.3 0.0 6.3e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 KOS21302.1 - 7.1e-06 25.7 0.0 0.0003 20.4 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS21302.1 - 0.00019 21.4 0.2 0.0038 17.2 0.1 2.4 1 1 2 3 3 3 1 RsgA GTPase SRPRB PF09439.10 KOS21302.1 - 0.003 17.0 0.0 0.0045 16.4 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 KOS21302.1 - 0.0033 17.2 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_5 PF07728.14 KOS21302.1 - 0.004 17.2 0.0 0.0067 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 KOS21302.1 - 0.0083 15.3 0.1 0.29 10.3 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 KOS21302.1 - 0.0089 16.4 0.1 0.024 15.0 0.0 1.6 1 1 1 2 2 2 1 AAA ATPase domain ATP_bind_1 PF03029.17 KOS21302.1 - 0.0091 15.8 0.2 0.31 10.8 0.0 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 KOS21302.1 - 0.0096 16.2 0.0 0.016 15.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 KOS21302.1 - 0.018 14.8 0.0 0.042 13.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain Septin PF00735.18 KOS21302.1 - 0.022 14.0 0.0 0.048 12.9 0.0 1.6 1 0 0 1 1 1 0 Septin AAA_7 PF12775.7 KOS21302.1 - 0.025 14.1 0.1 0.04 13.4 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region cobW PF02492.19 KOS21302.1 - 0.034 13.7 0.0 0.079 12.5 0.0 1.6 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ATPase_2 PF01637.18 KOS21302.1 - 0.067 13.1 0.3 0.13 12.2 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 KOS21302.1 - 0.08 13.3 0.0 0.5 10.8 0.0 2.0 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 KOS21302.1 - 0.09 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 NTPase TniB PF05621.11 KOS21302.1 - 0.12 11.8 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein NACHT PF05729.12 KOS21302.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Spo12 PF05032.12 KOS21303.1 - 6.3e-13 48.4 2.2 2.1e-12 46.7 2.2 1.9 1 0 0 1 1 1 1 Spo12 family DUF2264 PF10022.9 KOS21304.1 - 3e-121 404.8 0.9 5.2e-121 404.0 0.9 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) ASXH PF13919.6 KOS21305.1 - 1.8e-36 125.2 0.1 2.2e-36 124.9 0.1 1.1 1 0 0 1 1 1 1 Asx homology domain Paf1 PF03985.13 KOS21306.1 - 7.6e-100 334.9 0.1 9e-100 334.6 0.1 1.0 1 0 0 1 1 1 1 Paf1 Rer1 PF03248.13 KOS21307.1 - 2.5e-77 258.4 11.2 2.9e-77 258.2 11.2 1.0 1 0 0 1 1 1 1 Rer1 family DUF4131 PF13567.6 KOS21307.1 - 0.85 9.3 6.6 1.2 8.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Epimerase PF01370.21 KOS21308.1 - 5.1e-07 29.4 0.0 1.8e-06 27.6 0.0 1.9 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 KOS21308.1 - 2.4e-05 24.3 0.0 0.00037 20.4 0.0 2.5 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 KOS21308.1 - 0.00064 18.8 0.0 0.0047 16.0 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 KOS21308.1 - 0.0062 15.7 0.0 0.15 11.1 0.0 2.5 2 1 0 2 2 2 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KOS21308.1 - 0.036 13.4 0.0 0.052 12.9 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 KOS21308.1 - 0.085 12.3 0.0 0.28 10.6 0.0 1.8 2 0 0 2 2 2 0 short chain dehydrogenase SYF2 PF08231.12 KOS21309.1 - 1e-56 191.8 17.7 1e-56 191.8 17.7 2.0 2 0 0 2 2 2 1 SYF2 splicing factor UPF0449 PF15136.6 KOS21310.1 - 0.025 15.1 0.5 0.14 12.6 0.9 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 YEATS PF03366.16 KOS21311.1 - 8.4e-29 99.4 0.1 1.3e-28 98.8 0.1 1.3 1 0 0 1 1 1 1 YEATS family Nucleoside_tran PF01733.18 KOS21312.1 - 2.7e-24 86.1 25.4 4.4e-14 52.6 1.0 4.6 4 1 1 5 5 5 3 Nucleoside transporter MFS_1 PF07690.16 KOS21312.1 - 0.071 12.0 48.7 0.041 12.8 7.3 2.4 1 1 1 2 2 2 0 Major Facilitator Superfamily DUF3446 PF11928.8 KOS21312.1 - 1 9.7 20.3 0.46 10.8 15.9 2.2 2 0 0 2 2 2 0 Early growth response N-terminal domain Ins_P5_2-kin PF06090.12 KOS21313.1 - 1.7e-31 109.9 0.0 3.4e-31 108.9 0.0 1.5 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase HET PF06985.11 KOS21314.1 - 5.4e-19 69.0 1.0 2e-17 63.9 1.0 2.3 1 1 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Catalase PF00199.19 KOS21315.1 - 2.4e-165 550.3 0.0 3e-165 550.0 0.0 1.1 1 0 0 1 1 1 1 Catalase Catalase_C PF18011.1 KOS21315.1 - 2.3e-49 166.9 0.1 4.3e-49 166.0 0.1 1.5 1 0 0 1 1 1 1 C-terminal domain found in long catalases Catalase-rel PF06628.12 KOS21315.1 - 1.7e-19 69.8 0.1 3.2e-19 68.9 0.1 1.5 1 0 0 1 1 1 1 Catalase-related immune-responsive Mo-co_dimer PF03404.16 KOS21318.1 - 2.1e-08 34.3 0.6 2.1e-08 34.3 0.6 1.3 1 1 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Oxidored_molyb PF00174.19 KOS21319.1 - 1.5e-36 125.6 0.0 4.4e-36 124.1 0.0 1.7 1 1 1 2 2 2 1 Oxidoreductase molybdopterin binding domain HAD_2 PF13419.6 KOS21320.1 - 1.3e-06 28.7 0.0 2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase MIT PF04212.18 KOS21320.1 - 0.014 15.5 0.1 0.029 14.4 0.1 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain DUF2608 PF11019.8 KOS21320.1 - 0.043 13.3 0.0 1.7 8.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) Hydrolase PF00702.26 KOS21320.1 - 0.11 12.8 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Chromo PF00385.24 KOS21321.1 - 4.7e-12 45.6 3.3 1e-07 31.7 0.0 2.7 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Lipase_3 PF01764.25 KOS21322.1 - 9.7e-25 87.1 0.0 1.9e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) MMR_HSR1 PF01926.23 KOS21323.1 - 3.3e-07 30.4 0.1 3.6e-06 27.0 0.1 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS21323.1 - 0.00091 19.2 1.5 0.0018 18.2 0.1 2.2 2 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 KOS21323.1 - 0.0011 19.0 3.9 0.052 13.6 0.1 3.3 2 2 0 2 2 2 1 Dynamin family AIG1 PF04548.16 KOS21323.1 - 0.012 15.0 0.1 5.5 6.2 0.0 3.2 3 0 0 3 3 3 0 AIG1 family DUF2046 PF09755.9 KOS21323.1 - 0.034 13.4 6.3 0.068 12.4 6.3 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Streptin-Immun PF11083.8 KOS21323.1 - 0.81 10.1 4.7 0.43 11.0 0.6 2.5 3 0 0 3 3 3 0 Lantibiotic streptin immunity protein AAA_23 PF13476.6 KOS21323.1 - 3.7 8.0 12.2 1.7 9.1 0.1 2.6 2 1 0 2 2 2 0 AAA domain CAP59_mtransfer PF11735.8 KOS21324.1 - 8.3e-57 192.6 0.0 1e-56 192.3 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 Acetyltransf_CG PF14542.6 KOS21325.1 - 0.016 15.3 0.0 0.05 13.7 0.0 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase EII-Sor PF03609.14 KOS21327.1 - 0.031 13.7 0.3 0.031 13.7 0.3 1.5 2 0 0 2 2 2 0 PTS system sorbose-specific iic component Aminotran_5 PF00266.19 KOS21328.1 - 4.4e-33 114.7 0.0 2.3e-23 82.8 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Lysine_decarbox PF03641.14 KOS21329.1 - 3.4e-29 101.6 0.1 5.1e-29 101.0 0.1 1.2 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 KOS21329.1 - 9.6e-06 25.3 2.1 7.1e-05 22.4 1.1 2.5 1 1 0 2 2 2 1 SLOG cluster4 family LSDAT_prok PF18171.1 KOS21329.1 - 0.11 11.8 0.4 0.22 10.7 0.2 1.7 1 1 1 2 2 2 0 SLOG in TRPM, prokaryote DAGK_cat PF00781.24 KOS21329.1 - 0.3 10.7 2.3 4.5 6.9 0.1 2.5 3 0 0 3 3 3 0 Diacylglycerol kinase catalytic domain CLPTM1 PF05602.12 KOS21330.1 - 2.4e-150 501.3 0.0 3.1e-150 501.0 0.0 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) Longin PF13774.6 KOS21332.1 - 3.9e-23 81.3 0.2 6.2e-23 80.7 0.2 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 KOS21332.1 - 5.1e-15 55.0 0.0 1.6e-14 53.4 0.0 1.7 2 0 0 2 2 2 1 Synaptobrevin DUF1664 PF07889.12 KOS21332.1 - 0.028 14.5 0.3 1.2 9.2 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF5435 PF17503.2 KOS21332.1 - 0.038 13.7 0.0 0.052 13.3 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5435) DotU PF09850.9 KOS21332.1 - 0.067 12.9 0.5 0.16 11.7 0.3 1.6 2 0 0 2 2 2 0 Type VI secretion system protein DotU CTK3 PF12243.8 KOS21332.1 - 0.1 12.6 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 DUF4795 PF16043.5 KOS21332.1 - 0.11 12.1 0.8 0.3 10.6 0.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) TrkA_N PF02254.18 KOS21332.1 - 0.18 12.1 0.1 0.54 10.5 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain Sirohm_synth_C PF14823.6 KOS21332.1 - 1.4 8.7 3.4 13 5.6 0.2 2.9 3 0 0 3 3 3 0 Sirohaem biosynthesis protein C-terminal Elong_Iki1 PF10483.9 KOS21333.1 - 3e-104 348.7 0.0 3.4e-104 348.5 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 TrmE_N PF10396.9 KOS21334.1 - 6.7e-35 119.9 0.0 1.7e-34 118.6 0.0 1.7 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MnmE_helical PF12631.7 KOS21334.1 - 2.4e-30 106.2 0.1 3.1e-30 105.9 0.1 1.1 1 0 0 1 1 1 1 MnmE helical domain MMR_HSR1 PF01926.23 KOS21334.1 - 2.6e-18 66.1 0.0 4.3e-18 65.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS21334.1 - 6.4e-05 22.5 0.0 0.0001 21.9 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS21334.1 - 0.00022 21.3 0.0 0.00033 20.8 0.0 1.2 1 0 0 1 1 1 1 Dynamin family ABC_tran PF00005.27 KOS21334.1 - 0.036 14.6 0.1 0.076 13.5 0.1 1.5 1 0 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOS21334.1 - 0.076 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 KOS21334.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase MCM PF00493.23 KOS21334.1 - 0.19 10.8 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain UQ_con PF00179.26 KOS21335.1 - 3e-31 107.9 0.0 4e-31 107.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOS21335.1 - 0.021 15.1 0.1 0.043 14.1 0.1 1.6 1 1 0 1 1 1 0 RWD domain UFC1 PF08694.11 KOS21335.1 - 0.14 11.8 0.0 0.2 11.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 Cut12 PF11500.8 KOS21336.1 - 9e-43 145.7 9.8 9e-43 145.7 9.8 2.8 3 0 0 3 3 3 1 Spindle pole body formation-associated protein Pox_A_type_inc PF04508.12 KOS21336.1 - 1.8 8.5 6.5 36 4.4 0.4 4.1 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat CCDC84 PF14968.6 KOS21336.1 - 5.8 6.4 9.3 20 4.7 0.1 2.4 2 0 0 2 2 2 0 Coiled coil protein 84 UreF PF01730.16 KOS21337.1 - 9.5e-23 81.2 6.2 1.8e-22 80.3 6.2 1.4 1 0 0 1 1 1 1 UreF DUF429 PF04250.13 KOS21337.1 - 0.0072 16.1 0.4 0.016 15.0 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF429) Pox_A_type_inc PF04508.12 KOS21337.1 - 0.047 13.6 0.4 0.098 12.5 0.4 1.5 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Torus PF16131.5 KOS21338.1 - 1.2e-39 135.4 0.0 1.2e-39 135.4 0.0 2.5 3 0 0 3 3 3 1 Torus domain RRM_1 PF00076.22 KOS21338.1 - 5.9e-09 35.6 0.2 1.8e-08 34.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS21338.1 - 0.00038 20.4 0.0 0.0008 19.4 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif MoeA_C PF03454.15 KOS21338.1 - 0.00083 19.5 0.1 0.002 18.2 0.1 1.6 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) zf_CCCH_4 PF18345.1 KOS21338.1 - 0.0011 19.0 0.6 0.0023 17.9 0.6 1.6 1 0 0 1 1 1 1 Zinc finger domain SUIM_assoc PF16619.5 KOS21338.1 - 0.0034 17.4 3.1 0.0088 16.1 3.1 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 zf-CCCH PF00642.24 KOS21338.1 - 0.01 15.7 0.2 0.019 14.9 0.2 1.4 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF572 PF04502.13 KOS21338.1 - 4.3 6.9 7.3 0.24 11.0 1.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF572) MMR_HSR1_Xtn PF16897.5 KOS21339.1 - 1.1e-35 121.8 3.9 2e-35 121.0 1.9 2.1 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 KOS21339.1 - 8.3e-21 73.8 0.0 1.5e-20 73.0 0.0 1.4 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 KOS21339.1 - 1.2e-20 73.7 0.3 2.5e-20 72.6 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS21339.1 - 1.5e-12 47.3 0.0 2.3e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS21339.1 - 0.0024 17.9 4.0 0.053 13.6 0.0 2.7 2 1 1 3 3 3 2 Dynamin family Baculo_ME53 PF06061.11 KOS21339.1 - 0.05 12.8 5.0 0.035 13.3 2.5 1.9 2 1 0 2 2 2 0 Baculoviridae ME53 MeaB PF03308.16 KOS21339.1 - 0.092 11.7 0.1 0.19 10.7 0.1 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB cobW PF02492.19 KOS21340.1 - 2.5e-40 137.9 0.1 8.2e-40 136.3 0.0 1.8 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.14 KOS21340.1 - 0.00013 21.8 0.0 0.00034 20.5 0.0 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B DUF2722 PF10846.8 KOS21340.1 - 0.0095 14.9 1.5 0.012 14.6 1.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Viral_helicase1 PF01443.18 KOS21340.1 - 0.011 15.6 0.2 0.021 14.6 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Suf PF05843.14 KOS21340.1 - 0.012 15.6 1.4 0.018 15.1 1.4 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) AAA_11 PF13086.6 KOS21340.1 - 0.016 15.0 0.3 2.8 7.7 0.0 2.1 2 0 0 2 2 2 0 AAA domain DUF463 PF04317.12 KOS21340.1 - 0.019 13.9 0.0 0.019 13.9 0.0 1.6 2 0 0 2 2 2 0 YcjX-like family, DUF463 AAA_22 PF13401.6 KOS21340.1 - 0.045 14.0 0.2 0.1 12.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain ANAPC_CDC26 PF10471.9 KOS21340.1 - 0.07 14.0 8.3 0.13 13.1 8.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 AAA_14 PF13173.6 KOS21340.1 - 0.082 12.9 0.1 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain CobW_C PF07683.14 KOS21340.1 - 0.096 12.6 0.0 1.4 8.9 0.0 2.6 2 1 0 2 2 2 0 Cobalamin synthesis protein cobW C-terminal domain NTPase_1 PF03266.15 KOS21340.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 NTPase RsgA_GTPase PF03193.16 KOS21340.1 - 0.13 12.1 0.1 12 5.8 0.0 2.7 2 1 1 3 3 3 0 RsgA GTPase Roughex PF06020.11 KOS21340.1 - 0.9 8.6 4.4 1.3 8.0 4.4 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 KOS21340.1 - 2 8.0 10.0 3.2 7.3 10.0 1.2 1 0 0 1 1 1 0 Spt20 family PUL PF08324.11 KOS21341.1 - 2e-61 207.6 0.1 2.7e-61 207.2 0.1 1.2 1 0 0 1 1 1 1 PUL domain Peptidase_C97 PF05903.14 KOS21341.1 - 7.1e-35 120.1 0.0 1.2e-34 119.4 0.0 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain Thioredoxin PF00085.20 KOS21341.1 - 3.3e-12 46.3 0.0 6.8e-12 45.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin TraF PF13728.6 KOS21341.1 - 0.002 18.0 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 F plasmid transfer operon protein AhpC-TSA PF00578.21 KOS21341.1 - 0.0023 17.8 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_2 PF13098.6 KOS21341.1 - 0.012 16.0 0.1 0.042 14.3 0.1 1.9 1 1 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_3 PF13192.6 KOS21341.1 - 0.09 12.8 0.0 0.34 11.0 0.0 2.0 2 0 0 2 2 2 0 Thioredoxin domain OST3_OST6 PF04756.13 KOS21341.1 - 0.092 12.1 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family T4_deiodinase PF00837.17 KOS21341.1 - 0.094 12.0 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Iodothyronine deiodinase Redoxin PF08534.10 KOS21341.1 - 0.11 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Redoxin TMEM214 PF10151.9 KOS21342.1 - 0.017 13.6 6.0 0.021 13.3 6.0 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator RPN2_C PF18004.1 KOS21342.1 - 0.25 11.2 8.4 0.33 10.9 8.4 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ATP-synt_E PF05680.12 KOS21342.1 - 2.6 8.5 8.9 2 8.8 7.2 1.7 1 1 1 2 2 2 0 ATP synthase E chain eIF-3c_N PF05470.12 KOS21344.1 - 0.3 9.3 5.2 0.4 9.0 5.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Hus1 PF04005.12 KOS21345.1 - 2.8e-85 286.0 0.0 3.1e-85 285.8 0.0 1.0 1 0 0 1 1 1 1 Hus1-like protein Glyco_hydro_63 PF03200.16 KOS21346.1 - 2.4e-162 541.2 0.2 9.4e-161 535.9 0.0 2.7 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 KOS21346.1 - 3.5e-78 262.8 0.7 4.4e-78 262.5 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolase family 63 N-terminal domain Trehalase PF01204.18 KOS21346.1 - 4.4e-07 29.1 0.0 8.6e-07 28.1 0.0 1.4 1 0 0 1 1 1 1 Trehalase Ank_2 PF12796.7 KOS21347.1 - 1.7e-22 79.8 0.0 3.6e-11 43.5 0.0 2.6 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS21347.1 - 3.6e-14 52.9 0.1 1.4e-06 28.7 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 KOS21347.1 - 3.5e-11 43.0 0.0 0.00074 19.9 0.1 3.8 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 KOS21347.1 - 2.3e-08 33.6 0.0 0.0012 19.1 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 KOS21347.1 - 1.4e-07 31.6 0.1 0.015 15.6 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeats (many copies) FH2 PF02181.23 KOS21348.1 - 2.4e-85 286.9 3.6 2.4e-85 286.9 3.6 2.5 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_GBD PF06371.13 KOS21348.1 - 1.4e-59 200.8 0.0 1.4e-59 200.8 0.0 3.1 3 0 0 3 3 3 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 KOS21348.1 - 3.6e-49 167.0 0.5 3.6e-49 167.0 0.5 3.1 3 1 1 4 4 4 1 Diaphanous FH3 Domain Dna2 PF08696.11 KOS21348.1 - 8.7 6.1 10.7 0.033 14.0 0.7 2.1 2 0 0 2 2 2 0 DNA replication factor Dna2 SNRNP27 PF08648.12 KOS21349.1 - 4.3e-28 97.2 1.3 7e-28 96.5 1.3 1.3 1 0 0 1 1 1 1 U4/U6.U5 small nuclear ribonucleoproteins Vps55 PF04133.14 KOS21352.1 - 3.6e-44 149.5 7.7 4.1e-44 149.3 7.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 GtrA PF04138.14 KOS21352.1 - 0.2 11.9 5.9 0.27 11.5 5.9 1.2 1 0 0 1 1 1 0 GtrA-like protein Ribosomal_L28e PF01778.17 KOS21353.1 - 8.5e-40 136.1 0.9 8.5e-40 136.1 0.9 2.1 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 KOS21353.1 - 3.6e-27 94.9 21.0 3.6e-27 94.9 21.0 2.5 1 1 1 2 2 2 1 Mak16 protein C-terminal region BUD22 PF09073.10 KOS21353.1 - 1.5e-06 27.9 20.8 1.9e-06 27.5 20.8 1.1 1 0 0 1 1 1 1 BUD22 Reovirus_cap PF00979.17 KOS21353.1 - 0.015 14.5 0.1 0.023 13.9 0.1 1.2 1 0 0 1 1 1 0 Reovirus outer capsid protein, Sigma 3 PYC_OADA PF02436.18 KOS21353.1 - 0.017 14.9 2.9 0.025 14.3 2.2 1.6 1 1 0 1 1 1 0 Conserved carboxylase domain TFIIF_alpha PF05793.12 KOS21353.1 - 1.2 7.6 36.7 1.9 7.0 36.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SURF2 PF05477.11 KOS21353.1 - 1.7 8.3 15.7 3 7.5 15.7 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Rgp1 PF08737.10 KOS21353.1 - 2.2 7.4 4.4 2.6 7.1 4.4 1.2 1 0 0 1 1 1 0 Rgp1 Mso1_Sec1_bdg PF14475.6 KOS21354.1 - 1.2e-18 66.3 0.1 2.3e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 Sec1-binding region of Mso1 RabGAP-TBC PF00566.18 KOS21355.1 - 2.5e-37 128.6 0.2 4.5e-37 127.8 0.2 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PH_RBD PF12068.8 KOS21355.1 - 1.3e-05 24.7 0.0 0.081 12.4 0.0 3.2 3 0 0 3 3 3 2 Rab-binding domain (RBD) Sugar_tr PF00083.24 KOS21356.1 - 6.8e-86 288.9 34.1 4.8e-45 154.3 8.5 3.0 1 1 2 3 3 3 3 Sugar (and other) transporter MFS_1 PF07690.16 KOS21356.1 - 2.4e-15 56.3 29.7 9.1e-15 54.4 27.9 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3810 PF12725.7 KOS21356.1 - 0.07 12.5 0.2 4.4 6.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) adh_short PF00106.25 KOS21357.1 - 1.4e-16 60.6 0.0 2.5e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS21357.1 - 6e-12 45.6 0.0 9.3e-12 45.0 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KOS21357.1 - 0.0018 17.7 0.1 0.0032 16.9 0.1 1.3 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Pex14_N PF04695.13 KOS21357.1 - 0.045 14.4 8.2 0.088 13.5 8.2 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 KOS21357.1 - 0.15 12.0 7.3 0.22 11.5 7.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KOS21357.1 - 0.47 10.0 8.1 1.1 8.9 8.1 1.5 1 0 0 1 1 1 0 Spt20 family TRAPPC9-Trs120 PF08626.11 KOS21358.1 - 0 1284.9 0.0 0 1284.7 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit Chorismate_bind PF00425.18 KOS21359.1 - 1.6e-61 208.1 0.1 1.1e-34 120.1 0.0 3.6 3 1 0 3 3 3 3 chorismate binding enzyme GATase PF00117.28 KOS21359.1 - 4.7e-23 81.9 0.0 2.7e-22 79.5 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 KOS21359.1 - 6.1e-10 39.5 0.0 1.7e-09 38.1 0.0 1.7 2 0 0 2 2 2 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 KOS21359.1 - 3.3e-05 23.8 0.1 0.00019 21.3 0.1 2.0 1 1 0 1 1 1 1 Peptidase C26 PAP2_3 PF14378.6 KOS21360.1 - 6.6e-36 123.8 17.7 5.6e-28 97.9 3.3 2.7 3 0 0 3 3 3 2 PAP2 superfamily PAP2 PF01569.21 KOS21360.1 - 0.0025 17.6 0.3 0.0025 17.6 0.3 2.5 3 0 0 3 3 3 1 PAP2 superfamily Exo_endo_phos PF03372.23 KOS21362.1 - 0.0049 16.4 0.1 0.0071 15.9 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MFS_1 PF07690.16 KOS21363.1 - 5.4e-34 117.7 37.5 5.5e-29 101.2 23.1 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily SUIM_assoc PF16619.5 KOS21364.1 - 4.8e-07 29.8 12.7 0.06 13.4 0.0 4.0 3 1 0 3 3 3 3 Unstructured region C-term to UIM in Ataxin3 POPLD PF08170.12 KOS21364.1 - 0.6 10.5 2.9 8.3 6.8 0.0 2.8 2 1 0 2 2 2 0 POPLD (NUC188) domain GTP_cyclohydroI PF01227.22 KOS21365.1 - 6.2e-73 244.0 0.2 8.5e-73 243.6 0.2 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 KOS21365.1 - 0.0026 17.9 0.0 0.0047 17.1 0.0 1.4 1 0 0 1 1 1 1 QueF-like protein Ndc1_Nup PF09531.10 KOS21365.1 - 1.2 7.7 5.4 1.5 7.4 5.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup K_channel_TID PF07941.11 KOS21365.1 - 6.7 7.2 12.6 0.8 10.2 6.6 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Metallophos PF00149.28 KOS21368.1 - 2.1e-07 31.7 3.8 4.3e-07 30.6 3.8 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase ANAPC_CDC26 PF10471.9 KOS21369.1 - 2.4e-11 44.3 15.1 1.1e-10 42.2 15.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 Med3 PF11593.8 KOS21369.1 - 0.029 13.6 10.9 0.027 13.6 10.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hepcidin PF06446.12 KOS21369.1 - 2.5 8.6 4.7 5.6 7.4 1.2 2.0 2 0 0 2 2 2 0 Hepcidin TraG_N PF07916.11 KOS21369.1 - 4 6.2 7.5 4.3 6.1 7.5 1.0 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Homeobox_KN PF05920.11 KOS21370.1 - 1.2e-14 53.9 2.2 4.1e-14 52.2 2.2 2.0 1 0 0 1 1 1 1 Homeobox KN domain HTH_Tnp_Tc5 PF03221.16 KOS21370.1 - 5.2e-08 32.8 0.6 4.9e-06 26.5 0.1 3.2 2 1 0 2 2 2 1 Tc5 transposase DNA-binding domain Homeodomain PF00046.29 KOS21370.1 - 5.4e-05 23.0 0.5 0.00017 21.4 0.5 1.9 1 0 0 1 1 1 1 Homeodomain zf-C2H2 PF00096.26 KOS21370.1 - 0.0014 19.0 15.4 0.027 14.9 3.9 3.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS21370.1 - 0.0021 18.7 3.8 0.0021 18.7 3.8 5.0 5 0 0 5 5 5 1 C2H2-type zinc finger BIR PF00653.21 KOS21370.1 - 0.059 14.0 3.7 2.2 9.0 0.2 3.2 2 1 0 2 2 2 0 Inhibitor of Apoptosis domain zf-C2H2_jaz PF12171.8 KOS21370.1 - 0.33 11.3 2.1 1.5 9.2 2.1 2.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding HTH_Tnp_Tc5 PF03221.16 KOS21371.1 - 3.3e-06 27.0 0.3 0.045 13.8 0.0 2.5 2 0 0 2 2 2 2 Tc5 transposase DNA-binding domain Ponericin PF07442.11 KOS21371.1 - 0.7 10.0 0.0 0.7 10.0 0.0 2.9 3 1 1 4 4 4 0 Ponericin Zip PF02535.22 KOS21372.1 - 1.1e-56 192.5 5.5 5.5e-56 190.2 5.5 1.8 1 1 0 1 1 1 1 ZIP Zinc transporter Glyco_hydro_17 PF00332.18 KOS21373.1 - 5.7e-07 29.4 0.3 1.1e-06 28.5 0.1 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 17 RRM_1 PF00076.22 KOS21374.1 - 2.8e-30 103.9 0.3 2.6e-14 52.8 0.0 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 KOS21374.1 - 0.00028 21.0 0.0 0.54 10.4 0.0 2.5 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 KOS21374.1 - 0.00049 19.7 0.0 0.66 9.6 0.0 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 KOS21374.1 - 0.035 14.2 0.2 8.3 6.6 0.0 2.7 3 0 0 3 3 3 0 Limkain b1 DUF4783 PF16022.5 KOS21374.1 - 0.046 13.9 0.0 0.14 12.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4783) ETF PF01012.21 KOS21375.1 - 4.8e-45 153.7 1.0 5.7e-45 153.4 1.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Hamartin PF04388.12 KOS21376.1 - 3.9e-17 62.2 74.2 1.8e-13 50.1 73.2 4.2 1 1 0 1 1 1 1 Hamartin protein DJ-1_PfpI PF01965.24 KOS21377.1 - 6.9e-12 45.5 0.0 1.4e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 KOS21377.1 - 0.024 14.3 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 ThiJ/PfpI family-like MFS_1 PF07690.16 KOS21378.1 - 2.5e-33 115.5 39.1 2.5e-33 115.5 39.1 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Npa1 PF11707.8 KOS21379.1 - 7.5e-100 334.6 0.0 1.2e-99 333.9 0.0 1.3 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 KOS21379.1 - 2.9e-58 196.8 0.1 4.6e-57 192.8 0.0 2.5 2 0 0 2 2 2 1 Nucleolar pre-ribosomal-associated protein 1 Radial_spoke PF04712.12 KOS21379.1 - 0.15 11.0 5.0 0.24 10.3 5.0 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein MCM_bind PF09739.9 KOS21379.1 - 0.29 9.5 2.0 0.45 8.9 2.0 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NOA36 PF06524.12 KOS21379.1 - 0.75 9.1 8.8 1.2 8.4 8.8 1.2 1 0 0 1 1 1 0 NOA36 protein Myc_N PF01056.18 KOS21379.1 - 1.2 8.9 4.1 2 8.2 4.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region FCP1_C PF09309.10 KOS21379.1 - 1.7 8.5 12.0 2.8 7.8 12.0 1.2 1 0 0 1 1 1 0 FCP1, C-terminal FAM176 PF14851.6 KOS21379.1 - 2.1 8.0 6.2 4.5 6.9 6.2 1.5 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 KOS21379.1 - 2.6 6.2 13.0 3.8 5.6 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 KOS21379.1 - 2.8 8.1 12.9 5.4 7.2 12.9 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 His_Phos_2 PF00328.22 KOS21380.1 - 2.7e-62 211.3 0.0 3.2e-62 211.1 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) Fungal_trans PF04082.18 KOS21381.1 - 2.9e-23 82.3 0.3 4.3e-23 81.7 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain V-ATPase_G_2 PF16999.5 KOS21382.1 - 0.014 15.8 1.7 0.014 15.8 1.7 1.6 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit LRR_9 PF14580.6 KOS21383.1 - 7.7e-48 162.3 0.0 2.5e-47 160.6 0.0 1.9 1 0 0 1 1 1 1 Leucine-rich repeat Pkinase PF00069.25 KOS21383.1 - 9e-22 77.7 0.0 1.3e-21 77.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 KOS21383.1 - 5e-10 39.8 15.5 8.2e-06 26.5 0.0 5.8 5 0 0 5 5 5 2 WD domain, G-beta repeat HEAT PF02985.22 KOS21383.1 - 3.9e-09 36.0 3.8 0.53 10.7 0.1 6.7 6 0 0 6 6 6 3 HEAT repeat LRR_8 PF13855.6 KOS21383.1 - 1e-06 28.4 0.2 3.1e-06 26.9 0.2 1.9 1 0 0 1 1 1 1 Leucine rich repeat LRR_4 PF12799.7 KOS21383.1 - 1e-05 25.8 0.2 0.00039 20.8 0.0 3.0 1 1 0 2 2 2 1 Leucine Rich repeats (2 copies) HEAT_2 PF13646.6 KOS21383.1 - 2.3e-05 24.7 4.5 0.044 14.2 0.0 4.7 4 1 0 5 5 4 1 HEAT repeats Pkinase_Tyr PF07714.17 KOS21383.1 - 0.00022 20.6 0.0 0.00034 20.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS21383.1 - 0.0047 16.3 0.0 0.008 15.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like ANAPC4_WD40 PF12894.7 KOS21383.1 - 0.078 13.3 0.0 12 6.3 0.0 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4349 PF14257.6 KOS21383.1 - 0.33 10.4 2.6 0.58 9.6 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Cwf_Cwc_15 PF04889.12 KOS21383.1 - 1.4 8.6 5.2 2.8 7.6 5.2 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CBFD_NFYB_HMF PF00808.23 KOS21384.1 - 1.3e-10 41.4 0.1 0.00029 21.1 0.0 2.5 2 0 0 2 2 2 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TatD_DNase PF01026.21 KOS21386.1 - 2.1e-25 89.6 0.0 5.1e-25 88.3 0.0 1.7 1 1 0 1 1 1 1 TatD related DNase CDI PF02234.19 KOS21387.1 - 0.086 13.1 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor Pyridox_oxase_2 PF12766.7 KOS21388.1 - 9.1e-19 67.9 0.0 3.3e-18 66.2 0.0 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Fis1_TPR_C PF14853.6 KOS21389.1 - 6e-25 87.1 1.7 9.5e-25 86.4 1.7 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 KOS21389.1 - 5.1e-18 64.5 0.9 8.3e-18 63.8 0.1 1.7 2 0 0 2 2 2 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 KOS21389.1 - 0.005 16.9 2.2 0.01 15.9 2.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat Spc24 PF08286.11 KOS21390.1 - 6.2e-38 129.3 1.9 7.6e-36 122.5 0.0 2.1 2 0 0 2 2 2 2 Spc24 subunit of Ndc80 Nsp1_C PF05064.13 KOS21390.1 - 0.035 13.9 2.4 1.4 8.7 0.2 2.4 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF3073 PF11273.8 KOS21390.1 - 0.043 14.6 3.5 0.27 12.0 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) V_ATPase_I PF01496.19 KOS21390.1 - 0.062 11.2 0.9 0.066 11.1 0.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vps5 PF09325.10 KOS21390.1 - 0.12 11.9 5.1 0.19 11.2 5.1 1.4 1 1 0 1 1 1 0 Vps5 C terminal like Laminin_II PF06009.12 KOS21390.1 - 0.23 11.5 6.5 0.61 10.1 6.2 1.7 1 1 1 2 2 2 0 Laminin Domain II Retrotrans_gag PF03732.17 KOS21390.1 - 0.24 11.7 1.8 0.32 11.3 0.3 1.9 2 1 0 2 2 2 0 Retrotransposon gag protein FUSC PF04632.12 KOS21390.1 - 0.33 9.5 4.9 0.33 9.4 4.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FlxA PF14282.6 KOS21390.1 - 0.67 10.0 6.6 6.8 6.7 1.0 2.3 1 1 1 2 2 2 0 FlxA-like protein DUF4164 PF13747.6 KOS21390.1 - 1.7 8.9 12.1 2 8.7 9.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) SlyX PF04102.12 KOS21390.1 - 3 8.5 6.2 14 6.4 0.9 2.4 2 1 0 2 2 2 0 SlyX GTA_holin_3TM PF11351.8 KOS21390.1 - 6.4 7.3 7.7 1.3 9.5 0.7 2.1 1 1 1 2 2 2 0 Holin of 3TMs, for gene-transfer release La PF05383.17 KOS21391.1 - 9.3e-17 60.8 0.0 1.5e-16 60.1 0.0 1.4 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 KOS21391.1 - 1.9e-08 34.0 0.5 4.7e-08 32.8 0.5 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CDC50 PF03381.15 KOS21392.1 - 5.6e-96 321.3 0.0 6.8e-96 321.1 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Asp4 PF16996.5 KOS21392.1 - 0.82 9.5 5.1 0.2 11.4 0.5 2.2 2 0 0 2 2 2 0 Accessory secretory protein Sec Asp4 CMD PF02627.20 KOS21393.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family PRMT5_C PF17286.2 KOS21393.1 - 0.043 13.7 0.0 0.045 13.6 0.0 1.2 1 0 0 1 1 1 0 PRMT5 oligomerisation domain SPT16 PF08644.11 KOS21394.1 - 3e-55 186.5 0.2 3e-55 186.5 0.2 2.6 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 KOS21394.1 - 1.7e-45 154.7 5.6 3.4e-45 153.7 2.3 3.1 2 1 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 KOS21394.1 - 7.5e-26 91.1 0.0 1.5e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 KOS21394.1 - 1.7e-15 57.2 2.9 2.1e-15 56.9 0.3 2.6 3 0 0 3 3 3 1 Histone chaperone Rttp106-like DWNN PF08783.11 KOS21395.1 - 3.2e-30 104.2 0.1 5.4e-30 103.5 0.1 1.4 1 0 0 1 1 1 1 DWNN domain zf-CCHC_2 PF13696.6 KOS21395.1 - 9.6e-09 34.9 7.4 2.2e-08 33.8 6.2 2.0 2 0 0 2 2 2 1 Zinc knuckle zf-C3HC4_2 PF13923.6 KOS21395.1 - 0.0018 18.1 9.7 0.0018 18.1 9.7 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-CCHC PF00098.23 KOS21395.1 - 0.0031 17.5 1.2 0.0066 16.5 1.2 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-RING_2 PF13639.6 KOS21395.1 - 0.046 14.1 7.1 0.099 13.0 7.1 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_4 PF14570.6 KOS21395.1 - 0.15 11.9 6.6 0.31 10.9 6.6 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain FYVE_2 PF02318.16 KOS21395.1 - 0.6 10.3 5.7 0.092 13.0 1.5 1.8 3 0 0 3 3 2 0 FYVE-type zinc finger zf-C3HC4 PF00097.25 KOS21395.1 - 2 8.3 9.5 4 7.4 9.5 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS21395.1 - 4.6 7.3 13.6 0.55 10.2 8.0 2.0 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 KOS21395.1 - 6.5 7.0 9.4 22 5.3 9.4 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Apt1 PF10351.9 KOS21395.1 - 8.6 5.1 10.4 17 4.1 10.4 1.4 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_M20 PF01546.28 KOS21396.1 - 1.7e-32 112.8 0.0 6e-32 111.0 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOS21396.1 - 1.1e-11 44.5 0.0 1.8e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Transthyretin PF00576.21 KOS21397.1 - 1.7e-33 115.6 0.0 4e-33 114.4 0.0 1.6 1 1 0 1 1 1 1 HIUase/Transthyretin family ArsA_ATPase PF02374.15 KOS21398.1 - 8.6e-109 363.4 0.0 9.8e-109 363.2 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 KOS21398.1 - 1.4e-12 47.9 0.0 4.5e-12 46.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 KOS21398.1 - 2.4e-12 47.0 0.0 3.7e-12 46.4 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 KOS21398.1 - 6.4e-06 25.8 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 KOS21398.1 - 3.4e-05 23.4 1.5 0.00034 20.1 0.3 2.6 2 1 1 3 3 3 1 NUBPL iron-transfer P-loop NTPase CBP_BcsQ PF06564.12 KOS21398.1 - 3.8e-05 23.3 0.0 8.8e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ SRP54 PF00448.22 KOS21398.1 - 6.5e-05 22.6 0.0 0.0023 17.6 0.0 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_25 PF13481.6 KOS21398.1 - 0.035 13.7 0.0 0.081 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 KOS21398.1 - 0.059 12.5 0.0 0.092 11.9 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_16 PF13191.6 KOS21398.1 - 0.11 12.9 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 KOS21398.1 - 0.16 12.5 0.0 0.34 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain Amidohydro_2 PF04909.14 KOS21399.1 - 5.8e-08 32.9 0.0 9.3e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 Amidohydrolase PAF-AH_p_II PF03403.13 KOS21400.1 - 4.8e-17 61.5 0.1 8.6e-10 37.7 0.0 2.4 3 0 0 3 3 3 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KOS21400.1 - 5.1e-07 28.9 0.0 9.9e-07 27.9 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.11 KOS21400.1 - 0.00066 18.8 0.1 0.021 13.9 0.0 2.2 2 0 0 2 2 2 1 Chlorophyllase Peptidase_S9 PF00326.21 KOS21400.1 - 0.0049 16.4 0.5 0.01 15.3 0.1 1.6 2 0 0 2 2 2 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 KOS21400.1 - 0.012 14.8 0.0 0.59 9.3 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 KOS21400.1 - 0.18 11.5 0.1 2.5 7.8 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family 2OG-FeII_Oxy PF03171.20 KOS21401.1 - 0.0062 17.0 0.0 0.015 15.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3246 PF11596.8 KOS21401.1 - 0.081 12.4 1.1 0.12 11.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) Ribosomal_60s PF00428.19 KOS21401.1 - 3.4 8.3 5.5 6.1 7.5 0.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein p450 PF00067.22 KOS21402.1 - 7.9e-15 54.5 0.0 1.3e-14 53.8 0.0 1.4 2 0 0 2 2 2 1 Cytochrome P450 WD40 PF00400.32 KOS21403.1 - 1.1e-08 35.5 8.4 0.042 14.7 0.4 5.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21403.1 - 0.00057 20.1 0.0 13 6.1 0.0 4.2 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KOS21403.1 - 0.063 12.9 0.6 7.8 6.0 0.1 2.7 3 0 0 3 3 3 0 PQQ-like domain PQQ_3 PF13570.6 KOS21403.1 - 0.084 13.4 2.2 16 6.1 0.5 3.5 4 0 0 4 4 4 0 PQQ-like domain CENP-N PF05238.13 KOS21403.1 - 0.22 10.8 0.1 0.28 10.4 0.1 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like FRG1 PF06229.12 KOS21404.1 - 6.9e-43 146.6 0.2 1.9e-42 145.1 0.2 1.7 1 1 0 1 1 1 1 FRG1-like domain Fascin PF06268.13 KOS21404.1 - 0.0099 16.1 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 1 Fascin domain F-box-like PF12937.7 KOS21405.1 - 6e-11 42.1 0.1 1.3e-10 41.0 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS21405.1 - 0.00023 21.0 0.0 0.00055 19.7 0.0 1.7 1 1 0 1 1 1 1 F-box domain MIT PF04212.18 KOS21405.1 - 0.12 12.5 0.2 0.12 12.5 0.2 1.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 KOS21405.1 - 0.15 12.2 0.3 1.3 9.3 0.6 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Mito_carr PF00153.27 KOS21406.1 - 4.9e-60 199.5 1.4 2.7e-21 75.3 0.1 4.1 4 0 0 4 4 4 4 Mitochondrial carrier protein EzrA PF06160.12 KOS21408.1 - 0.052 11.7 0.6 0.085 11.0 0.3 1.4 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA MtrF PF09472.10 KOS21408.1 - 0.07 12.5 0.1 0.2 11.0 0.0 1.8 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) DUF1664 PF07889.12 KOS21408.1 - 0.22 11.6 1.0 0.59 10.2 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) EcsB PF05975.12 KOS21408.1 - 0.29 9.9 0.0 0.39 9.5 0.0 1.1 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB MBOAT PF03062.19 KOS21410.1 - 1.8e-45 155.9 17.0 1.8e-45 155.9 17.0 2.3 4 0 0 4 4 4 1 MBOAT, membrane-bound O-acyltransferase family Cortexin PF11057.8 KOS21410.1 - 0.19 11.6 2.0 0.69 9.8 0.2 3.0 3 1 0 3 3 3 0 Cortexin of kidney PLDc_2 PF13091.6 KOS21411.1 - 6e-16 58.5 0.0 7e-07 29.2 0.0 3.5 3 0 0 3 3 3 3 PLD-like domain PLDc PF00614.22 KOS21411.1 - 3.7e-13 49.0 2.0 1e-06 28.6 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif GLTP PF08718.11 KOS21412.1 - 4.8e-46 156.7 0.0 7.3e-46 156.1 0.0 1.3 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) DUF5098 PF17023.5 KOS21412.1 - 0.17 10.8 0.0 0.23 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5098) Ribonucleas_3_3 PF14622.6 KOS21414.1 - 2.5e-09 37.4 0.0 0.0023 18.1 0.1 2.3 2 0 0 2 2 2 2 Ribonuclease-III-like Ribonuclease_3 PF00636.26 KOS21414.1 - 6.7e-05 23.5 0.0 0.00038 21.0 0.0 2.2 1 1 0 1 1 1 1 Ribonuclease III domain dsrm PF00035.26 KOS21414.1 - 0.002 18.8 0.0 0.0059 17.3 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF5559 PF17714.1 KOS21414.1 - 0.13 12.1 3.7 5.2 6.9 3.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5559) CAP_N PF01213.19 KOS21414.1 - 4.6 6.6 14.3 5.1 6.5 12.4 2.0 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 KOS21414.1 - 7.8 6.5 8.9 13 5.8 8.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator p450 PF00067.22 KOS21415.1 - 7.5e-72 242.5 0.0 1.1e-71 242.0 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Flavodoxin_1 PF00258.25 KOS21415.1 - 5.9e-25 88.1 0.0 1.7e-24 86.6 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 KOS21415.1 - 1.2e-14 54.4 0.0 2.3e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 KOS21415.1 - 2.1e-10 41.2 0.0 5.5e-10 39.9 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FMN_red PF03358.15 KOS21415.1 - 0.0038 17.0 0.0 1.1 8.9 0.0 2.4 1 1 1 2 2 2 2 NADPH-dependent FMN reductase Flavodoxin_5 PF12724.7 KOS21415.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain zf-RING_2 PF13639.6 KOS21416.1 - 2.3e-13 50.2 6.7 3.5e-13 49.6 6.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOS21416.1 - 1.2e-10 41.0 3.1 1.2e-10 41.0 3.1 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOS21416.1 - 1.3e-09 37.7 6.8 2.1e-09 37.1 6.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS21416.1 - 2.3e-08 33.8 4.0 3.3e-08 33.2 4.0 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS21416.1 - 3.9e-07 29.8 5.8 6.4e-07 29.2 5.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS21416.1 - 3.4e-06 27.2 10.0 8e-06 26.0 10.0 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOS21416.1 - 2.5e-05 24.0 4.1 4.6e-05 23.2 4.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOS21416.1 - 3.7e-05 23.6 3.4 5.7e-05 23.0 3.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOS21416.1 - 9.3e-05 22.4 2.0 0.00021 21.3 2.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 KOS21416.1 - 0.00093 19.2 1.5 0.0019 18.2 1.5 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DUF2370 PF10176.9 KOS21416.1 - 0.0034 17.1 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) Zn_ribbon_17 PF17120.5 KOS21416.1 - 0.057 13.0 5.6 0.093 12.4 5.6 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type RINGv PF12906.7 KOS21416.1 - 0.16 12.1 7.1 0.34 11.1 7.1 1.6 1 1 0 1 1 1 0 RING-variant domain zf-Nse PF11789.8 KOS21416.1 - 0.24 11.2 1.6 0.46 10.3 1.6 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit PHD PF00628.29 KOS21416.1 - 0.29 11.1 5.3 0.52 10.2 5.3 1.4 1 0 0 1 1 1 0 PHD-finger zf-RING_4 PF14570.6 KOS21416.1 - 0.32 10.8 3.8 0.57 10.0 3.8 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3H2C3 PF17122.5 KOS21416.1 - 4.8 7.3 5.2 7.8 6.6 5.2 1.4 1 0 0 1 1 1 0 Zinc-finger BRO1 PF03097.18 KOS21417.1 - 2.2e-133 444.8 0.8 2.2e-133 444.8 0.8 1.8 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOS21417.1 - 1.4e-75 254.4 22.8 3.3e-75 253.1 22.8 1.6 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV COG2 PF06148.11 KOS21417.1 - 0.41 10.7 9.1 0.18 11.9 1.0 3.6 3 0 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 CorA PF01544.18 KOS21418.1 - 0.0025 17.2 0.1 0.0047 16.3 0.1 1.5 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Kelch_5 PF13854.6 KOS21419.1 - 1.1e-18 66.8 6.4 3.7e-05 23.6 0.0 6.8 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 KOS21419.1 - 1.1e-15 57.4 14.6 2.1e-05 24.4 0.1 7.6 8 0 0 8 8 8 3 Galactose oxidase, central domain Kelch_2 PF07646.15 KOS21419.1 - 1.8e-14 53.1 6.2 5.8e-06 26.1 0.0 6.8 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 KOS21419.1 - 3.4e-14 52.7 19.6 0.0011 19.2 0.1 8.5 8 1 0 8 8 8 4 Galactose oxidase, central domain Kelch_6 PF13964.6 KOS21419.1 - 2.5e-12 46.6 4.9 5.6e-05 23.3 0.0 6.0 6 1 1 7 7 7 3 Kelch motif Kelch_1 PF01344.25 KOS21419.1 - 2.6e-12 46.1 7.4 0.0041 16.7 0.0 6.0 6 0 0 6 6 6 4 Kelch motif 2Fe-2S_thioredx PF01257.19 KOS21420.1 - 1.3e-58 196.9 0.0 1.7e-58 196.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin Metallophos_C PF14008.6 KOS21421.1 - 0.12 13.2 0.1 6.9 7.6 0.0 2.3 2 0 0 2 2 2 0 Iron/zinc purple acid phosphatase-like protein C Glyco_hydro_43 PF04616.14 KOS21422.1 - 1e-51 175.9 3.5 1.3e-51 175.6 3.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 43 DUF1080 PF06439.11 KOS21422.1 - 2.2e-07 31.1 0.0 3.7e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Domain of Unknown Function (DUF1080) DUF5122 PF17164.4 KOS21422.1 - 0.074 13.4 1.5 0.6 10.4 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller p450 PF00067.22 KOS21423.1 - 3.1e-58 197.6 0.0 3.6e-58 197.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 KOS21424.1 - 0.0027 16.5 0.0 0.0031 16.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 LPAM_1 PF08139.12 KOS21424.1 - 7.7 7.2 6.6 16 6.2 0.6 2.7 2 0 0 2 2 2 0 Prokaryotic membrane lipoprotein lipid attachment site ERO1 PF04137.15 KOS21425.1 - 1.2e-132 442.4 0.0 7.3e-132 439.8 0.0 1.9 1 1 1 2 2 2 2 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) PCRF PF03462.18 KOS21425.1 - 1.8 8.4 5.0 6.4 6.6 0.9 2.1 1 1 1 2 2 2 0 PCRF domain CKS PF01111.19 KOS21426.1 - 5.9e-28 96.9 0.9 9.5e-28 96.3 0.9 1.3 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit HVSL PF09749.9 KOS21427.1 - 6.3e-48 163.3 0.0 7.8e-48 163.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein CS PF04969.16 KOS21429.1 - 1.5e-16 61.2 0.0 2.7e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 CS domain UQ_con PF00179.26 KOS21430.1 - 8.9e-36 122.6 0.0 1.2e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme IlvN PF07991.12 KOS21431.1 - 1.4e-45 154.8 0.0 2.2e-45 154.2 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 KOS21431.1 - 9.4e-38 129.7 0.0 1.5e-37 129.1 0.0 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain PRP1_N PF06424.12 KOS21432.1 - 8.8e-51 172.2 9.3 1.9e-50 171.1 9.3 1.6 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 KOS21432.1 - 1.1e-23 81.9 40.0 0.0019 18.9 0.3 14.5 5 3 10 15 15 15 10 Tetratricopeptide repeat TPR_19 PF14559.6 KOS21432.1 - 8.8e-22 77.4 17.7 0.00045 20.7 0.0 10.6 7 3 3 10 10 10 7 Tetratricopeptide repeat TPR_16 PF13432.6 KOS21432.1 - 4.5e-10 40.0 24.8 0.00024 21.7 3.3 8.4 7 2 1 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21432.1 - 1.2e-07 31.3 6.7 0.0043 17.2 0.1 6.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 KOS21432.1 - 4.9e-07 29.7 10.2 0.17 12.3 0.1 8.8 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS21432.1 - 4.1e-06 26.5 17.9 0.11 12.7 0.1 8.9 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_21 PF09976.9 KOS21432.1 - 0.00079 19.2 15.6 0.017 14.9 1.1 4.2 4 1 1 5 5 5 3 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 KOS21432.1 - 0.00098 19.6 4.6 7.6 7.4 0.1 6.9 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS21432.1 - 0.0033 17.5 15.8 0.012 15.7 0.7 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS21432.1 - 0.0044 17.0 0.3 2 8.6 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS21432.1 - 0.034 14.0 3.0 2.8 7.9 0.4 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Wzy_C_2 PF11846.8 KOS21432.1 - 0.13 12.2 2.2 16 5.4 0.0 3.8 4 0 0 4 4 4 0 Virulence factor membrane-bound polymerase, C-terminal LPP PF04728.13 KOS21433.1 - 0.00068 20.0 1.3 0.0013 19.1 0.7 1.7 1 1 1 2 2 2 1 Lipoprotein leucine-zipper Apolipoprotein PF01442.18 KOS21433.1 - 0.0056 16.6 0.2 0.0074 16.2 0.2 1.1 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain AviRa PF11599.8 KOS21433.1 - 0.07 12.6 0.3 0.11 11.9 0.2 1.3 1 1 0 1 1 1 0 RRNA methyltransferase AviRa ApoLp-III PF07464.11 KOS21433.1 - 0.082 13.0 1.1 0.14 12.2 1.1 1.5 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Phasin PF05597.11 KOS21433.1 - 0.084 12.9 2.6 0.3 11.1 1.0 1.9 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) YtxH PF12732.7 KOS21433.1 - 0.56 10.8 14.8 0.32 11.5 2.2 2.4 1 1 1 2 2 2 0 YtxH-like protein DUF883 PF05957.13 KOS21433.1 - 0.78 10.4 3.4 1.3 9.7 1.9 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) TIMELESS_C PF05029.13 KOS21434.1 - 0.012 14.8 10.0 0.018 14.2 10.0 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region SSP160 PF06933.11 KOS21434.1 - 0.37 8.9 2.9 0.71 8.0 2.9 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1635 PF07795.11 KOS21434.1 - 6.3 6.6 8.7 13 5.5 8.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Ribosomal_L16 PF00252.18 KOS21435.1 - 1.1e-44 151.6 0.0 1.4e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e Vps62 PF06101.11 KOS21436.1 - 1e-10 40.6 0.8 2.2e-10 39.5 0.8 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 DUF1302 PF06980.11 KOS21436.1 - 0.15 10.7 0.1 0.23 10.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1302) DUF2730 PF10805.8 KOS21437.1 - 0.013 15.5 0.2 0.055 13.6 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF3772 PF12607.8 KOS21437.1 - 0.037 13.8 0.4 0.13 12.0 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Vac7 PF12751.7 KOS21438.1 - 5.4e-148 493.5 5.3 5.4e-148 493.5 5.3 2.2 2 0 0 2 2 2 1 Vacuolar segregation subunit 7 DUF2721 PF11026.8 KOS21438.1 - 0.1 12.5 0.1 0.1 12.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) RrnaAD PF00398.20 KOS21439.1 - 5.4e-63 212.5 0.0 7.1e-63 212.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 KOS21439.1 - 2e-06 28.4 0.0 4.5e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS21439.1 - 3.7e-05 24.3 0.0 9.3e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS21439.1 - 0.00093 19.9 0.4 0.0074 17.0 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain PCMT PF01135.19 KOS21439.1 - 0.0025 17.6 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 KOS21439.1 - 0.0039 16.8 0.0 0.0068 16.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 KOS21439.1 - 0.0048 16.2 0.0 0.0073 15.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 KOS21439.1 - 0.016 15.1 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.18 KOS21439.1 - 0.047 13.0 0.0 0.08 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain Methyltransf_28 PF02636.17 KOS21439.1 - 0.082 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase RRN3 PF05327.11 KOS21439.1 - 0.24 9.9 4.7 0.36 9.3 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ribosomal_L7Ae PF01248.26 KOS21440.1 - 2.3e-24 85.0 0.0 2.6e-24 84.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family SARAF PF06682.12 KOS21441.1 - 0.96 9.0 6.1 2.3 7.8 6.1 1.6 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis HSP70 PF00012.20 KOS21442.1 - 6.4e-168 559.7 3.6 6.4e-168 559.7 3.6 1.8 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 KOS21442.1 - 5.5e-12 45.1 0.0 5.5e-12 45.1 0.0 2.5 3 0 0 3 3 3 1 MreB/Mbl protein BcrAD_BadFG PF01869.20 KOS21442.1 - 0.0098 15.4 0.1 0.057 12.9 0.1 2.3 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 KOS21442.1 - 0.087 13.3 9.3 0.24 11.8 0.0 3.5 3 2 0 3 3 3 0 Cell division protein FtsA Vps52 PF04129.12 KOS21444.1 - 1.1e-120 403.7 0.2 1.5e-120 403.4 0.2 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 KOS21444.1 - 0.0001 20.9 1.7 0.00041 18.9 1.7 1.9 1 1 0 1 1 1 1 Exocyst complex component Sec3 ANTAR PF03861.14 KOS21444.1 - 0.045 13.6 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 ANTAR domain eIF-5a PF01287.20 KOS21445.1 - 1.4e-23 82.7 0.2 2e-23 82.3 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 KOS21445.1 - 0.038 14.0 0.0 0.063 13.3 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) KOW-like domain FAD_binding_1 PF00667.20 KOS21446.1 - 6.5e-30 104.4 0.0 6.8e-28 97.8 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Flavodoxin_1 PF00258.25 KOS21446.1 - 2e-29 102.6 0.0 3e-29 102.0 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 KOS21446.1 - 1.5e-11 44.9 0.0 3.9e-11 43.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain zf-RRN7 PF11781.8 KOS21447.1 - 1.3e-11 44.0 1.6 2.1e-11 43.3 1.6 1.3 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 ArfGap PF01412.18 KOS21448.1 - 6.6e-32 110.0 0.3 1.1e-31 109.3 0.3 1.3 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf SAP PF02037.27 KOS21449.1 - 2.4e-11 43.1 0.2 4.3e-11 42.3 0.2 1.5 1 0 0 1 1 1 1 SAP domain GATase PF00117.28 KOS21450.1 - 8.9e-47 159.3 0.0 1.2e-46 158.9 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 KOS21450.1 - 7.4e-46 155.1 0.0 1.2e-45 154.5 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 KOS21450.1 - 1.1e-05 25.3 0.2 0.00062 19.6 0.2 2.5 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 KOS21450.1 - 0.0051 16.6 0.0 0.0088 15.9 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family Yip1 PF04893.17 KOS21451.1 - 8.7e-12 45.1 18.3 8.7e-12 45.1 18.3 1.4 1 1 0 1 1 1 1 Yip1 domain DDDD PF10161.9 KOS21451.1 - 0.15 11.8 0.0 0.5 10.2 0.0 1.9 1 0 0 1 1 1 0 Putative mitochondrial precursor protein Ribosomal_L22e PF01776.17 KOS21452.1 - 4.6e-46 155.7 1.8 5.7e-46 155.4 1.8 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Mito_carr PF00153.27 KOS21453.1 - 1.3e-50 169.2 0.3 5.2e-18 64.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein G-patch PF01585.23 KOS21454.1 - 3.9e-12 45.8 0.0 1.2e-11 44.3 0.0 1.8 1 0 0 1 1 1 1 G-patch domain CENP-B_dimeris PF09026.10 KOS21454.1 - 1.3 9.4 15.9 0.85 10.0 5.8 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Anp1 PF03452.14 KOS21456.1 - 1.3e-105 352.5 0.0 1.6e-105 352.2 0.0 1.1 1 0 0 1 1 1 1 Anp1 p450 PF00067.22 KOS21457.1 - 1.3e-52 179.1 0.0 2e-52 178.5 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Fungal_trans PF04082.18 KOS21458.1 - 2.2e-40 138.4 0.0 4.3e-40 137.4 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21458.1 - 3.1e-08 33.6 8.0 7.8e-08 32.3 8.0 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain AAA PF00004.29 KOS21459.1 - 1.5e-09 38.4 0.0 2.6e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS21459.1 - 1.9e-06 28.2 0.0 7.5e-06 26.3 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_5 PF07728.14 KOS21459.1 - 0.00012 22.1 0.1 0.00041 20.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOS21459.1 - 0.00066 19.5 0.0 0.0013 18.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOS21459.1 - 0.00092 19.4 0.0 0.0026 17.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOS21459.1 - 0.0011 18.9 0.0 0.0038 17.2 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 KOS21459.1 - 0.0022 18.4 0.3 0.012 16.0 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 KOS21459.1 - 0.0083 16.2 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS21459.1 - 0.017 14.8 0.1 0.051 13.3 0.1 1.8 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 KOS21459.1 - 0.035 13.4 0.0 0.077 12.3 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin NTPase_1 PF03266.15 KOS21459.1 - 0.094 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 NTPase NB-ARC PF00931.22 KOS21459.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.6 KOS21459.1 - 0.13 12.6 0.1 0.59 10.5 0.1 2.0 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 KOS21459.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KOS21459.1 - 0.16 12.5 0.1 0.45 11.0 0.1 1.8 1 0 0 1 1 1 0 ABC transporter Mcp5_PH PF12814.7 KOS21460.1 - 5.1e-48 162.2 0.0 8.2e-48 161.5 0.0 1.3 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology OTU PF02338.19 KOS21461.1 - 1.8e-22 80.2 0.1 8.2e-22 78.1 0.1 2.1 1 1 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 KOS21461.1 - 0.0016 17.9 0.0 0.067 12.6 0.0 2.2 1 1 1 2 2 2 2 Peptidase C65 Otubain SUIM_assoc PF16619.5 KOS21461.1 - 0.007 16.4 2.4 0.017 15.1 2.4 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF2357 PF09823.9 KOS21461.1 - 0.017 14.4 2.7 0.33 10.2 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) CCDC-167 PF15188.6 KOS21461.1 - 2.3 8.6 10.8 0.14 12.5 4.1 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Spt20 PF12090.8 KOS21461.1 - 6.2 6.4 8.4 0.27 10.8 2.3 1.8 2 0 0 2 2 2 0 Spt20 family Chitin_synth_1 PF01644.17 KOS21462.1 - 3.2e-67 225.6 0.0 4.6e-67 225.1 0.0 1.2 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 KOS21462.1 - 1.8e-27 95.1 0.1 3.2e-27 94.3 0.1 1.4 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 KOS21462.1 - 1.4e-26 93.2 0.1 1e-21 77.2 0.0 2.4 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS21462.1 - 3.9e-09 36.7 0.0 3.9e-09 36.7 0.0 2.3 1 1 1 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOS21462.1 - 0.0003 20.8 0.0 0.00095 19.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyltransferase like family 2 UAA PF08449.11 KOS21463.1 - 3.7e-10 39.5 15.7 4.8e-10 39.1 15.7 1.1 1 0 0 1 1 1 1 UAA transporter family Htr2 PF17909.1 KOS21463.1 - 0.056 13.7 0.4 0.056 13.7 0.4 2.5 2 0 0 2 2 2 0 Htr2 transmembrane domain EamA PF00892.20 KOS21463.1 - 0.15 12.2 33.6 0.083 13.1 10.0 2.2 2 0 0 2 2 2 0 EamA-like transporter family ArfGap PF01412.18 KOS21464.1 - 7.1e-38 129.3 1.4 2.1e-37 127.8 0.1 2.2 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf UBA PF00627.31 KOS21464.1 - 0.011 15.7 0.1 0.037 13.9 0.1 1.9 1 1 0 1 1 1 0 UBA/TS-N domain SARAF PF06682.12 KOS21465.1 - 0.17 11.5 0.0 0.21 11.2 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GAPT PF11770.8 KOS21465.1 - 0.18 11.6 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) ECH_1 PF00378.20 KOS21467.1 - 3.3e-37 128.2 1.9 3.2e-22 79.1 1.8 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 KOS21467.1 - 1.5e-27 97.0 0.3 1.5e-25 90.4 0.2 2.1 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Ku PF02735.16 KOS21469.1 - 6e-41 140.4 0.0 1.2e-40 139.4 0.0 1.5 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 KOS21469.1 - 1.2e-32 113.5 0.0 1.8e-32 112.9 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 KOS21469.1 - 3.8e-24 85.2 0.8 3.8e-24 85.2 0.8 2.2 2 0 0 2 2 2 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 KOS21469.1 - 4.9e-08 32.5 0.1 1.3e-07 31.2 0.1 1.8 1 0 0 1 1 1 1 SAP domain Toprim_3 PF13362.6 KOS21469.1 - 0.054 13.9 1.3 1.3 9.5 0.1 3.5 3 1 1 4 4 4 0 Toprim domain Ferrochelatase PF00762.19 KOS21470.1 - 2.3e-99 332.5 0.0 2.7e-99 332.3 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Septin PF00735.18 KOS21471.1 - 8.5e-118 392.7 0.1 8.5e-118 392.7 0.1 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 KOS21471.1 - 2.6e-08 33.9 1.1 5.7e-08 32.8 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 KOS21471.1 - 2.1e-05 25.1 1.0 0.024 15.2 0.0 2.5 2 0 0 2 2 2 1 ABC transporter GTP_EFTU PF00009.27 KOS21471.1 - 3.4e-05 23.5 2.3 0.00042 19.9 0.0 2.9 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KOS21471.1 - 0.0014 18.0 1.9 0.0028 17.0 0.0 2.2 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 KOS21471.1 - 0.0017 18.8 0.3 0.0048 17.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOS21471.1 - 0.0021 18.0 0.8 0.0021 18.0 0.8 3.5 3 1 0 3 3 3 1 RsgA GTPase Roc PF08477.13 KOS21471.1 - 0.0025 18.0 0.0 0.0058 16.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOS21471.1 - 0.0067 16.0 0.1 0.053 13.1 0.0 2.4 2 0 0 2 2 2 1 Ras family AAA_22 PF13401.6 KOS21471.1 - 0.01 16.1 0.5 0.044 14.1 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 KOS21471.1 - 0.017 14.8 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS21471.1 - 0.019 15.5 8.6 3.6 8.0 7.7 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 KOS21471.1 - 0.044 13.8 8.3 0.84 9.7 0.0 3.6 3 1 0 3 3 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 KOS21471.1 - 0.059 12.7 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 KOS21471.1 - 0.061 13.1 2.2 4.2 7.1 0.0 3.2 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_24 PF13479.6 KOS21471.1 - 0.066 12.9 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 KOS21471.1 - 0.096 12.2 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Exonuc_VII_L PF02601.15 KOS21471.1 - 0.1 12.1 6.5 0.15 11.6 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit RNA_helicase PF00910.22 KOS21471.1 - 0.14 12.6 0.4 0.72 10.3 0.0 2.2 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 KOS21471.1 - 0.21 11.7 4.6 4.5 7.3 0.0 2.7 3 0 0 3 3 2 0 Helicase HerA, central domain Atg14 PF10186.9 KOS21471.1 - 0.54 9.3 8.0 0.81 8.7 8.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AP1AR PF15745.5 KOS21471.1 - 0.85 9.2 10.5 1.6 8.3 10.5 1.4 1 0 0 1 1 1 0 AP-1 complex-associated regulatory protein DUF3987 PF13148.6 KOS21471.1 - 1.7 7.6 0.0 1.7 7.6 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) UPF0242 PF06785.11 KOS21471.1 - 4.6 7.3 15.1 7.6 6.6 15.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Strep_SA_rep PF06696.11 KOS21471.1 - 5.7 7.1 6.7 1.6 8.8 3.0 2.0 1 1 1 2 2 2 0 Streptococcal surface antigen repeat Amidohydro_1 PF01979.20 KOS21472.1 - 3.1e-73 247.1 0.0 3.6e-73 246.9 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 KOS21472.1 - 4.4e-13 49.5 5.0 5.2e-10 39.4 2.9 2.5 2 1 1 3 3 3 2 Amidohydrolase family tRNA_int_end_N2 PF12928.7 KOS21472.1 - 0.15 12.2 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term Ribonuclease_T2 PF00445.18 KOS21474.1 - 1.1e-41 143.1 0.1 1.6e-41 142.6 0.1 1.1 1 0 0 1 1 1 1 Ribonuclease T2 family Abhydrolase_3 PF07859.13 KOS21475.1 - 5.3e-40 137.5 0.0 7.2e-40 137.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold COesterase PF00135.28 KOS21475.1 - 1.4e-06 27.5 0.1 5.5e-06 25.5 0.1 1.7 1 1 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 KOS21475.1 - 0.0027 17.2 0.0 0.57 9.6 0.0 2.3 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 KOS21475.1 - 0.021 14.6 0.3 0.092 12.5 0.0 2.1 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase tRNA-synt_2 PF00152.20 KOS21476.1 - 1e-69 235.1 0.0 1.5e-69 234.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF2156 PF09924.9 KOS21476.1 - 5.2e-14 51.9 0.1 9.1e-14 51.2 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2156) tRNA_anti-codon PF01336.25 KOS21476.1 - 2.4e-05 24.2 0.0 4.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 KOS21476.1 - 0.0011 18.5 0.1 0.36 10.3 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FMN_dh PF01070.18 KOS21477.1 - 1.5e-120 402.4 0.2 1.9e-120 402.1 0.2 1.1 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 KOS21477.1 - 6.5e-18 64.7 0.0 2e-17 63.1 0.0 1.9 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 KOS21477.1 - 4.1e-08 32.8 0.0 6.5e-08 32.1 0.0 1.2 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 KOS21477.1 - 0.00015 20.9 0.2 0.00047 19.3 0.1 1.7 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 KOS21477.1 - 0.0065 15.9 0.1 0.01 15.3 0.1 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 KOS21477.1 - 0.085 12.3 2.6 0.99 8.8 0.1 2.6 2 1 0 3 3 3 0 Histidine biosynthesis protein UPF0257 PF06788.13 KOS21477.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) RabGAP-TBC PF00566.18 KOS21478.1 - 7.3e-20 71.5 0.0 9.4e-20 71.2 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ACAS_N PF16177.5 KOS21478.1 - 0.18 11.7 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus MIF4G PF02854.19 KOS21479.1 - 2.1e-50 171.3 0.0 5.2e-29 101.4 0.0 4.0 4 0 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 KOS21479.1 - 3.6e-11 43.9 2.7 3.6e-11 43.9 2.7 3.6 3 1 1 4 4 4 1 Up-frameshift suppressor 2 Fib_alpha PF08702.10 KOS21479.1 - 0.016 15.4 0.6 0.016 15.4 0.6 2.5 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GCP5-Mod21 PF14609.6 KOS21479.1 - 6 5.1 10.9 12 4.1 10.9 1.4 1 0 0 1 1 1 0 gamma-Tubulin ring complex non-core subunit mod21 GTP_EFTU PF00009.27 KOS21480.1 - 1.3e-34 119.4 0.0 1.3e-34 119.4 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 KOS21480.1 - 2.8e-19 69.2 0.0 7.5e-19 67.8 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.6 KOS21480.1 - 3.3e-09 36.5 0.1 1.5e-08 34.4 0.1 2.2 1 0 0 1 1 1 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 KOS21480.1 - 5.3e-08 33.1 0.1 5.3e-08 33.1 0.1 3.8 4 0 0 4 4 4 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 KOS21480.1 - 1.6e-07 31.4 0.2 2e-06 27.8 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase Roc PF08477.13 KOS21480.1 - 7e-05 23.0 0.0 0.00018 21.7 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ATP_bind_1 PF03029.17 KOS21480.1 - 0.0006 19.7 0.0 0.0022 17.8 0.0 2.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein LtuB PF17455.2 KOS21480.1 - 0.082 13.5 0.2 0.082 13.5 0.2 3.0 3 0 0 3 3 3 0 Late transcription unit B CAP_N PF01213.19 KOS21481.1 - 0.019 14.5 2.4 0.037 13.5 2.4 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal LysM PF01476.20 KOS21481.1 - 0.046 13.8 0.0 0.091 12.8 0.0 1.5 1 0 0 1 1 1 0 LysM domain Fungal_trans PF04082.18 KOS21482.1 - 1.3e-37 129.3 0.0 3.6e-37 127.8 0.0 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21482.1 - 0.002 18.2 1.3 0.0038 17.3 1.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ATP_synt_H PF05493.13 KOS21483.1 - 1.4e-14 54.3 4.7 2.3e-14 53.6 4.7 1.4 1 1 0 1 1 1 1 ATP synthase subunit H PRA1 PF03208.19 KOS21483.1 - 0.0056 16.3 0.4 0.0063 16.2 0.4 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF1075 PF06388.11 KOS21483.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) Ac76 PF05814.11 KOS21483.1 - 0.12 12.4 0.1 0.14 12.2 0.1 1.0 1 0 0 1 1 1 0 Orf76 (Ac76) Arv1 PF04161.13 KOS21484.1 - 6.6e-78 261.7 0.0 7.9e-78 261.4 0.0 1.1 1 0 0 1 1 1 1 Arv1-like family Nodulin-like PF06813.13 KOS21485.1 - 2.3e-14 53.5 2.6 5.2e-14 52.3 2.6 1.6 1 0 0 1 1 1 1 Nodulin-like MFS_1 PF07690.16 KOS21485.1 - 8.2e-14 51.3 32.4 1e-10 41.1 20.6 3.0 1 1 1 3 3 3 3 Major Facilitator Superfamily C6_DPF PF10170.9 KOS21485.1 - 0.17 12.3 0.3 0.34 11.3 0.3 1.4 1 0 0 1 1 1 0 Cysteine-rich domain Serinc PF03348.15 KOS21486.1 - 2.3e-139 465.0 6.6 2.6e-139 464.8 6.6 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) Carn_acyltransf PF00755.20 KOS21487.1 - 1.7e-205 684.1 0.0 1.9e-205 684.0 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase ETF PF01012.21 KOS21488.1 - 4.3e-44 150.6 2.0 7.1e-44 149.9 2.0 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 KOS21488.1 - 3.9e-33 113.3 0.4 3.9e-33 113.3 0.4 1.7 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain CAP_N PF01213.19 KOS21490.1 - 1.7e-109 366.1 0.3 2.2e-109 365.8 0.3 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 KOS21490.1 - 1.2e-54 184.2 0.9 1.6e-54 183.8 0.9 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 KOS21490.1 - 0.03 14.1 1.8 0.41 10.4 0.7 2.2 1 1 1 2 2 2 0 Tubulin binding cofactor C PRIMA1 PF16101.5 KOS21490.1 - 1.9 8.6 8.1 4.3 7.4 8.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Hydrophobin_2 PF06766.11 KOS21491.1 - 4e-20 71.5 9.8 5.1e-20 71.2 9.8 1.1 1 0 0 1 1 1 1 Fungal hydrophobin Thioredoxin_4 PF13462.6 KOS21493.1 - 8.9e-05 22.7 0.0 0.00052 20.2 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin DSBA PF01323.20 KOS21493.1 - 0.0012 18.7 1.8 0.64 9.8 0.1 3.0 2 1 0 2 2 2 2 DSBA-like thioredoxin domain Phage_TAC_6 PF09550.10 KOS21493.1 - 0.014 15.8 0.1 0.043 14.2 0.1 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC FeS_assembly_P PF01883.19 KOS21495.1 - 0.00014 22.0 0.1 0.0014 18.8 0.1 2.2 1 1 0 1 1 1 1 Iron-sulfur cluster assembly protein GTP_EFTU PF00009.27 KOS21496.1 - 7e-47 159.5 0.0 1.1e-46 158.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFTUD2 PF16004.5 KOS21496.1 - 4.5e-36 124.1 6.6 9.8e-36 123.0 6.6 1.6 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus EFG_IV PF03764.18 KOS21496.1 - 2.7e-24 85.3 0.0 8e-24 83.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 KOS21496.1 - 3.9e-18 65.3 0.0 9.6e-18 64.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOS21496.1 - 1.8e-09 37.9 0.0 4e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 KOS21496.1 - 1.8e-07 31.2 0.2 9.1e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 KOS21496.1 - 0.00014 21.9 0.1 0.00031 20.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Thiolase_N PF00108.23 KOS21497.1 - 2e-92 309.2 1.4 3.6e-92 308.4 1.4 1.4 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS21497.1 - 1.5e-45 153.8 1.1 2.7e-44 149.8 0.2 2.6 2 1 0 2 2 2 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOS21497.1 - 5.2e-06 26.2 1.2 0.00041 20.0 0.5 2.8 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KOS21497.1 - 0.23 11.3 2.7 9.4 6.2 0.1 3.0 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Sin3a_C PF16879.5 KOS21498.1 - 2.5e-71 240.7 0.4 5.7e-71 239.6 0.4 1.6 1 0 0 1 1 1 1 C-terminal domain of Sin3a protein Sin3_corepress PF08295.12 KOS21498.1 - 1.5e-39 134.0 0.3 9.7e-39 131.4 0.0 2.4 2 0 0 2 2 2 1 Sin3 family co-repressor PAH PF02671.21 KOS21498.1 - 1.8e-22 79.2 3.0 2.1e-17 63.0 2.5 2.8 2 0 0 2 2 2 2 Paired amphipathic helix repeat CdvA PF18822.1 KOS21498.1 - 0.088 12.6 0.4 0.39 10.5 0.0 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain TSP_NTD PF17804.1 KOS21498.1 - 5 7.3 7.8 0.68 10.2 0.0 3.1 3 1 0 3 3 3 0 Tail specific protease N-terminal domain PAH PF02671.21 KOS21499.1 - 0.0046 17.1 0.4 0.0046 17.1 0.4 2.6 1 1 1 2 2 1 1 Paired amphipathic helix repeat DUF775 PF05603.12 KOS21499.1 - 0.036 13.6 3.0 0.056 13.0 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF2828 PF11443.8 KOS21499.1 - 0.05 11.7 0.2 0.068 11.3 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Glt_symporter PF03616.14 KOS21499.1 - 0.098 11.3 1.2 0.14 10.8 1.2 1.2 1 0 0 1 1 1 0 Sodium/glutamate symporter DUF4471 PF14740.6 KOS21499.1 - 0.23 10.7 3.1 0.14 11.3 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) Eapp_C PF10238.9 KOS21499.1 - 0.25 11.4 6.4 0.13 12.3 0.9 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Pex14_N PF04695.13 KOS21499.1 - 0.65 10.6 14.2 0.18 12.5 8.8 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3371 PF11851.8 KOS21499.1 - 0.82 10.8 10.5 2.4 9.3 7.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) DUF2722 PF10846.8 KOS21499.1 - 0.94 8.3 25.4 0.037 13.0 19.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Spt20 PF12090.8 KOS21499.1 - 0.97 9.0 31.2 0.1 12.2 26.2 1.8 2 0 0 2 2 2 0 Spt20 family DUF3464 PF11947.8 KOS21499.1 - 1.4 8.7 8.3 0.29 10.9 2.3 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 V_ATPase_I PF01496.19 KOS21499.1 - 1.6 6.5 5.2 0.43 8.5 1.0 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Suf PF05843.14 KOS21499.1 - 2.2 8.2 12.4 0.11 12.5 6.8 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 KOS21499.1 - 2.6 6.7 9.7 4.4 6.0 9.7 1.3 1 1 0 1 1 1 0 Presenilin DUF4770 PF15994.5 KOS21499.1 - 2.8 8.2 8.6 0.14 12.3 2.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) DUF5327 PF17261.2 KOS21499.1 - 4.2 8.2 15.9 35 5.2 13.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5327) HIG_1_N PF04588.13 KOS21500.1 - 1.7e-23 82.6 1.0 1.7e-23 82.6 1.0 1.6 2 0 0 2 2 2 1 Hypoxia induced protein conserved region RskA PF10099.9 KOS21500.1 - 0.83 9.9 11.8 2 8.6 10.9 1.9 1 1 1 2 2 2 0 Anti-sigma-K factor rskA DAO PF01266.24 KOS21500.1 - 1.6 8.2 5.1 2.1 7.8 5.1 1.1 1 0 0 1 1 1 0 FAD dependent oxidoreductase ZZ PF00569.17 KOS21501.1 - 8.4e-10 38.3 7.2 1.5e-09 37.5 7.2 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type EF-hand_1 PF00036.32 KOS21501.1 - 4.4e-07 29.0 12.5 0.0028 17.1 0.3 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 KOS21501.1 - 2.5e-06 26.9 6.2 0.0041 16.9 0.3 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 KOS21501.1 - 5.6e-05 23.5 12.9 0.0056 17.1 0.2 4.6 4 0 0 4 4 4 2 EF-hand domain pair C1_2 PF03107.16 KOS21501.1 - 0.12 12.7 10.4 0.24 11.7 10.4 1.4 1 0 0 1 1 1 0 C1 domain TLD PF07534.16 KOS21503.1 - 4.4e-28 98.2 0.0 7.4e-28 97.5 0.0 1.4 1 0 0 1 1 1 1 TLD DUF1773 PF08593.10 KOS21503.1 - 3.3e-07 31.2 0.1 9.6e-07 29.8 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function Cwf_Cwc_15 PF04889.12 KOS21503.1 - 0.45 10.2 8.7 0.78 9.4 8.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 KOS21503.1 - 1.1 9.7 12.2 2.3 8.7 12.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 KOS21503.1 - 2.3 7.5 7.8 3.4 6.9 7.8 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 KOS21503.1 - 6.8 7.2 13.7 15 6.0 13.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Translin PF01997.16 KOS21505.1 - 1.9e-56 191.3 0.0 2.2e-56 191.1 0.0 1.1 1 0 0 1 1 1 1 Translin family Hemerythrin PF01814.23 KOS21505.1 - 0.072 13.7 1.3 0.23 12.1 1.2 2.0 1 1 0 1 1 1 0 Hemerythrin HHE cation binding domain HBD PF18534.1 KOS21505.1 - 0.12 12.6 0.1 16 5.7 0.0 2.5 2 1 0 2 2 2 0 Helical bundle domain DUF3689 PF12463.8 KOS21505.1 - 0.13 11.5 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) VIT1 PF01988.19 KOS21506.1 - 5.3e-57 193.1 7.7 6.4e-57 192.9 7.7 1.1 1 0 0 1 1 1 1 VIT family Ada_Zn_binding PF02805.16 KOS21507.1 - 3.5e-30 103.8 6.6 6.4e-30 103.0 6.6 1.4 1 0 0 1 1 1 1 Metal binding domain of Ada HTH_AraC PF00165.23 KOS21507.1 - 1e-06 28.7 0.0 2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_18 PF12833.7 KOS21507.1 - 1.3e-05 25.3 0.3 4e-05 23.8 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain UPF0175 PF03683.13 KOS21507.1 - 0.16 11.7 0.0 0.42 10.4 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0175) Mannosyl_trans PF05007.13 KOS21508.1 - 1.3e-78 264.4 12.8 1.7e-78 264.1 12.8 1.1 1 0 0 1 1 1 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 KOS21508.1 - 8.5e-10 38.2 18.1 1.5e-09 37.4 18.1 1.4 1 1 0 1 1 1 1 GPI transamidase subunit PIG-U GT87 PF09594.10 KOS21508.1 - 0.00013 21.8 25.8 0.00013 21.8 25.8 3.0 3 1 0 3 3 3 1 Glycosyltransferase family 87 MARVEL PF01284.23 KOS21510.1 - 9.7e-09 35.4 15.9 2.1e-08 34.3 15.6 1.8 1 1 0 1 1 1 1 Membrane-associating domain AAA_23 PF13476.6 KOS21510.1 - 0.0071 16.9 7.8 0.0087 16.6 7.8 1.3 1 0 0 1 1 1 1 AAA domain Borrelia_P83 PF05262.11 KOS21510.1 - 0.012 14.1 6.1 0.014 13.9 6.1 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein FapA PF03961.13 KOS21510.1 - 0.064 11.8 4.0 0.081 11.5 4.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Neur_chan_memb PF02932.16 KOS21510.1 - 0.11 12.5 4.1 0.22 11.6 4.1 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HemX PF04375.14 KOS21510.1 - 0.17 11.1 30.1 0.3 10.3 30.1 1.4 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2070 PF09843.9 KOS21510.1 - 0.41 8.9 6.6 0.57 8.4 6.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Suf PF05843.14 KOS21510.1 - 0.42 10.5 14.0 0.6 10.0 14.0 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Exonuc_VII_L PF02601.15 KOS21510.1 - 0.58 9.7 15.0 0.81 9.2 15.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DNA_pol3_a_NII PF11490.8 KOS21510.1 - 0.93 9.4 20.4 1.7 8.6 20.4 1.4 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II SARAF PF06682.12 KOS21510.1 - 1 9.0 14.8 0.031 13.9 8.6 1.6 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3792 PF12670.7 KOS21510.1 - 2.9 8.1 12.1 0.32 11.2 7.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3792) MMR1 PF08505.10 KOS21510.1 - 6.1 7.1 21.6 8.2 6.6 21.6 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CDC37_N PF03234.14 KOS21510.1 - 9.2 7.2 17.9 14 6.6 17.9 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Cmc1 PF08583.10 KOS21511.1 - 6e-15 55.0 6.7 1.5e-14 53.7 6.7 1.7 1 1 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 KOS21511.1 - 0.0055 16.8 2.7 2.2 8.5 0.2 2.4 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 KOS21511.1 - 0.031 14.3 0.7 0.069 13.2 0.7 1.6 1 1 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, DUF3128 PF11326.8 KOS21511.1 - 0.062 13.7 7.7 3.9 7.9 3.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3128) Utp11 PF03998.13 KOS21512.1 - 2.3e-62 211.1 14.3 2.6e-62 210.9 14.3 1.0 1 0 0 1 1 1 1 Utp11 protein CENP-B_dimeris PF09026.10 KOS21512.1 - 0.045 14.1 13.0 0.045 14.1 13.0 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SLATT_5 PF18160.1 KOS21512.1 - 0.22 10.9 0.5 0.42 9.9 0.5 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DNA_pol_phi PF04931.13 KOS21512.1 - 1.6 6.7 13.8 2.2 6.3 13.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi tRNA-synt_2 PF00152.20 KOS21513.1 - 9.8e-79 264.7 0.0 1.3e-78 264.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF1998 PF09369.10 KOS21513.1 - 0.094 13.5 0.0 0.27 12.0 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1998) tRNA-synt_2d PF01409.20 KOS21513.1 - 0.11 11.9 0.0 1 8.8 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) Ribosomal_S30 PF04758.14 KOS21514.1 - 3e-25 88.2 5.6 3.3e-25 88.0 5.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Cys_Met_Meta_PP PF01053.20 KOS21515.1 - 2.3e-24 85.6 0.0 3.1e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOS21515.1 - 2.8e-07 30.1 0.0 4.4e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II ANAPC4 PF12896.7 KOS21515.1 - 0.087 12.3 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 ADH_N PF08240.12 KOS21516.1 - 4.4e-28 97.3 0.7 9.7e-28 96.2 0.1 1.9 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS21516.1 - 2e-21 76.3 0.1 3.9e-21 75.4 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS21516.1 - 3.8e-10 39.6 0.3 6.7e-10 38.8 0.3 1.4 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 KOS21516.1 - 4.8e-05 24.4 0.0 0.00016 22.7 0.0 1.9 1 1 0 1 1 1 1 Zinc-binding dehydrogenase AdoHcyase_NAD PF00670.21 KOS21516.1 - 0.0042 17.2 0.4 0.25 11.4 0.5 2.2 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Prot_ATP_ID_OB PF16450.5 KOS21516.1 - 0.0059 16.5 3.2 0.059 13.3 0.1 2.9 3 0 0 3 3 3 1 Proteasomal ATPase OB C-terminal domain Pyr_redox_2 PF07992.14 KOS21516.1 - 0.0077 15.5 0.9 0.024 13.9 0.9 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOS21516.1 - 0.017 13.9 0.6 0.026 13.2 0.6 1.3 1 0 0 1 1 1 0 HI0933-like protein AlaDh_PNT_C PF01262.21 KOS21516.1 - 0.024 13.9 1.1 0.036 13.4 1.1 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 KOS21516.1 - 0.05 13.2 0.3 0.096 12.2 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAD_binding_3 PF01494.19 KOS21516.1 - 0.18 11.0 0.2 0.26 10.5 0.2 1.2 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 KOS21516.1 - 0.36 9.8 2.6 0.51 9.3 2.6 1.2 1 0 0 1 1 1 0 FAD binding domain ANTH PF07651.16 KOS21517.1 - 4.9e-68 229.1 0.1 7.6e-68 228.5 0.1 1.3 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 KOS21517.1 - 5.3e-08 32.9 0.0 9.8e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 ENTH domain MAT1 PF06391.13 KOS21518.1 - 8.7e-33 113.9 0.4 1.1e-32 113.5 0.4 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 KOS21518.1 - 3.2e-29 100.6 9.4 5.3e-29 99.9 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS21518.1 - 3.8e-05 23.5 6.9 7.3e-05 22.6 6.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS21518.1 - 0.0025 17.6 8.9 0.0051 16.6 8.9 1.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) MRP-S26 PF14943.6 KOS21518.1 - 0.0031 17.4 6.4 0.0053 16.7 6.4 1.3 1 0 0 1 1 1 1 Mitochondrial ribosome subunit S26 DUF3797 PF12677.7 KOS21518.1 - 0.0038 17.1 2.5 0.0088 15.9 2.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3797) zf-RING_2 PF13639.6 KOS21518.1 - 0.0047 17.2 6.6 0.0089 16.3 6.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 KOS21518.1 - 0.031 14.1 9.1 0.13 12.1 9.2 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 KOS21518.1 - 0.04 14.1 3.5 0.072 13.2 3.5 1.4 1 0 0 1 1 1 0 zinc RING finger of MSL2 zf-piccolo PF05715.13 KOS21518.1 - 0.083 13.1 2.5 0.17 12.1 2.5 1.5 1 0 0 1 1 1 0 Piccolo Zn-finger zf-RING_4 PF14570.6 KOS21518.1 - 0.24 11.2 12.1 2.2 8.1 12.3 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain CorA PF01544.18 KOS21518.1 - 0.3 10.4 3.2 0.42 9.9 3.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-UDP PF14569.6 KOS21518.1 - 0.47 10.6 8.5 3.1 8.0 8.5 2.1 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-RING_5 PF14634.6 KOS21518.1 - 0.55 10.2 11.1 2.2 8.3 11.2 1.9 1 1 1 2 2 2 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 KOS21518.1 - 3.2 7.9 5.9 6.1 7.0 5.9 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 KOS21518.1 - 4.4 7.6 6.9 8.5 6.6 6.9 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KOS21518.1 - 6.3 6.7 8.3 11 6.0 2.5 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 PigN PF04987.14 KOS21519.1 - 2.5e-27 95.8 12.3 3.5e-15 55.8 1.3 2.3 1 1 1 2 2 2 2 Phosphatidylinositolglycan class N (PIG-N) Phosphodiest PF01663.22 KOS21519.1 - 2.1e-09 37.5 5.4 2.7e-07 30.5 2.6 2.3 1 1 1 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 KOS21519.1 - 2.8e-09 36.8 0.1 5e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 Sulfatase Metalloenzyme PF01676.18 KOS21519.1 - 0.00024 20.6 0.1 0.00038 19.9 0.1 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily ETC_C1_NDUFA5 PF04716.14 KOS21520.1 - 5.8e-25 86.9 4.6 1e-23 82.9 0.2 2.4 2 0 0 2 2 2 2 ETC complex I subunit conserved region QLQ PF08880.11 KOS21520.1 - 0.076 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 QLQ Cys_Met_Meta_PP PF01053.20 KOS21521.1 - 1.4e-82 277.3 0.5 6e-48 163.3 0.0 3.0 1 1 2 3 3 3 3 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 KOS21521.1 - 0.0083 14.7 0.0 0.011 14.3 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase GDC-P PF02347.16 KOS21521.1 - 0.013 14.4 0.0 0.02 13.7 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein NIR_SIR_ferr PF03460.17 KOS21521.1 - 0.072 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain AAA PF00004.29 KOS21522.1 - 2.6e-19 70.0 0.2 2.2e-17 63.7 0.2 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 KOS21522.1 - 1.6e-05 25.4 0.0 1.9e-05 25.1 0.0 1.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 KOS21522.1 - 2.6e-05 24.0 0.2 6.3e-05 22.8 0.2 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOS21522.1 - 2.7e-05 24.2 0.5 0.00019 21.4 0.1 2.0 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS21522.1 - 4.6e-05 23.7 0.1 0.00055 20.2 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.14 KOS21522.1 - 5.2e-05 23.4 0.1 0.0086 16.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 KOS21522.1 - 6.7e-05 23.1 0.0 6.9e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 KOS21522.1 - 9.7e-05 22.4 0.1 0.00017 21.5 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 KOS21522.1 - 0.00012 22.6 0.0 0.00014 22.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 KOS21522.1 - 0.00017 21.0 0.3 0.00027 20.4 0.2 1.2 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 KOS21522.1 - 0.00017 21.9 0.0 0.00021 21.7 0.0 1.2 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 KOS21522.1 - 0.00018 21.8 0.0 0.0002 21.7 0.0 1.1 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOS21522.1 - 0.00038 20.3 0.0 0.00047 19.9 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 KOS21522.1 - 0.0013 18.7 0.0 0.0054 16.8 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.6 KOS21522.1 - 0.0015 18.1 0.4 0.0094 15.5 0.2 1.9 1 1 1 2 2 2 1 AAA domain AAA_7 PF12775.7 KOS21522.1 - 0.0017 17.9 0.1 0.008 15.7 0.0 1.8 1 1 1 2 2 2 1 P-loop containing dynein motor region TIP49 PF06068.13 KOS21522.1 - 0.0018 17.6 0.3 0.0088 15.3 0.1 1.8 1 1 1 2 2 2 1 TIP49 P-loop domain Sigma54_activat PF00158.26 KOS21522.1 - 0.0033 17.1 0.0 0.0056 16.4 0.0 1.4 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 KOS21522.1 - 0.0035 17.3 0.0 0.0047 16.8 0.0 1.2 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 KOS21522.1 - 0.0047 17.4 0.0 0.0064 17.0 0.0 1.3 1 1 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 KOS21522.1 - 0.0052 16.1 0.0 0.0064 15.8 0.0 1.1 1 0 0 1 1 1 1 Zeta toxin Sigma54_activ_2 PF14532.6 KOS21522.1 - 0.0063 16.6 0.0 0.0066 16.6 0.0 1.1 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_24 PF13479.6 KOS21522.1 - 0.0093 15.7 0.1 0.012 15.4 0.1 1.2 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOS21522.1 - 0.0098 16.3 0.1 0.017 15.5 0.1 1.4 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 KOS21522.1 - 0.01 15.3 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein TsaE PF02367.17 KOS21522.1 - 0.012 15.6 0.0 0.012 15.6 0.0 1.1 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE IPT PF01745.16 KOS21522.1 - 0.018 14.5 0.0 0.024 14.0 0.0 1.1 1 0 0 1 1 1 0 Isopentenyl transferase SKI PF01202.22 KOS21522.1 - 0.024 14.7 0.0 0.028 14.5 0.0 1.1 1 0 0 1 1 1 0 Shikimate kinase AAA_3 PF07726.11 KOS21522.1 - 0.026 14.4 0.0 0.04 13.8 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Guanylate_kin PF00625.21 KOS21522.1 - 0.03 14.0 0.0 0.046 13.4 0.0 1.3 1 1 0 1 1 1 0 Guanylate kinase ATPase_2 PF01637.18 KOS21522.1 - 0.031 14.2 0.0 0.058 13.3 0.0 1.5 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Parvo_NS1 PF01057.17 KOS21522.1 - 0.034 13.2 0.0 0.047 12.8 0.0 1.1 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 KOS21522.1 - 0.038 13.8 0.0 0.039 13.8 0.0 1.1 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PduV-EutP PF10662.9 KOS21522.1 - 0.047 13.4 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 KOS21522.1 - 0.071 12.6 0.1 0.096 12.1 0.1 1.2 1 0 0 1 1 1 0 PhoH-like protein Viral_helicase1 PF01443.18 KOS21522.1 - 0.097 12.4 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 KOS21522.1 - 0.11 11.6 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 KOS21522.1 - 0.16 11.2 0.0 0.18 10.9 0.0 1.1 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 KOS21522.1 - 0.16 12.1 0.0 0.17 12.0 0.0 1.1 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 KOS21522.1 - 0.17 11.3 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Cytidylate_kin PF02224.18 KOS21522.1 - 0.18 11.5 0.0 0.23 11.1 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase Ran_BP1 PF00638.18 KOS21524.1 - 6.5e-13 49.0 0.1 2.7e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 RanBP1 domain Nucleoplasmin PF03066.15 KOS21524.1 - 0.11 13.0 0.6 1.7 9.2 0.2 2.2 2 0 0 2 2 2 0 Nucleoplasmin/nucleophosmin domain Yip1 PF04893.17 KOS21525.1 - 4e-13 49.5 12.9 5.7e-13 48.9 12.9 1.4 1 0 0 1 1 1 1 Yip1 domain 7TM_transglut PF14402.6 KOS21525.1 - 0.043 13.3 6.3 0.063 12.7 6.3 1.1 1 0 0 1 1 1 0 7 transmembrane helices usually fused to an inactive transglutaminase DUF1282 PF06930.12 KOS21525.1 - 0.78 9.5 10.7 1.6 8.5 10.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) DUF2070 PF09843.9 KOS21525.1 - 3.7 5.7 8.7 4.5 5.4 8.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PQ-loop PF04193.14 KOS21526.1 - 1e-23 82.9 2.2 2.3e-13 49.7 0.2 2.4 2 0 0 2 2 2 2 PQ loop repeat SprA-related PF12118.8 KOS21527.1 - 8.7e-05 21.8 5.0 8.7e-05 21.8 5.0 3.3 2 1 0 3 3 3 1 SprA-related family DUF1656 PF07869.12 KOS21528.1 - 0.17 11.9 3.0 0.31 11.1 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1656) SAPS PF04499.15 KOS21528.1 - 1.1 7.9 16.0 0.074 11.8 11.3 1.4 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 KOS21528.1 - 1.4 8.2 39.1 0.059 12.7 33.3 1.5 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 KOS21528.1 - 4.6 5.3 51.6 0.048 11.9 43.9 1.5 2 0 0 2 2 2 0 Nop14-like family Bromodomain PF00439.25 KOS21529.1 - 1e-24 86.4 0.6 2.1e-24 85.4 0.6 1.5 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 KOS21529.1 - 6.8e-08 32.8 0.0 1.3e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS21529.1 - 7.7e-07 29.1 0.2 1.9e-06 27.9 0.1 1.6 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS21529.1 - 0.0003 21.2 0.1 0.00065 20.1 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOS21529.1 - 0.1 13.3 0.1 5.9 7.6 0.0 2.7 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain NAPRTase PF04095.16 KOS21530.1 - 1.4e-49 168.8 0.0 2.7e-24 86.1 0.2 2.1 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 KOS21530.1 - 8.1e-35 119.9 0.0 1.8e-34 118.8 0.0 1.6 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain WD40 PF00400.32 KOS21531.1 - 5.1e-11 43.0 6.1 0.17 12.8 0.0 8.1 9 0 0 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS21531.1 - 2e-07 31.2 0.4 0.099 12.9 0.0 6.6 4 2 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 KOS21531.1 - 7.9e-05 22.3 10.3 0.00022 20.9 0.3 4.6 3 1 2 5 5 5 2 PQQ-like domain PQQ PF01011.21 KOS21531.1 - 0.0076 16.1 0.1 0.45 10.5 0.0 3.1 3 0 0 3 3 3 1 PQQ enzyme repeat SUIM_assoc PF16619.5 KOS21531.1 - 0.84 9.7 11.3 5.3 7.2 6.0 3.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Rad4 PF03835.15 KOS21532.1 - 1.7e-14 53.7 2.0 3.3e-14 52.8 2.0 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 KOS21532.1 - 1.3e-10 41.7 3.0 3.5e-10 40.3 3.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily C6_DPF PF10170.9 KOS21533.1 - 0.43 11.0 2.8 0.77 10.2 2.8 1.4 1 0 0 1 1 1 0 Cysteine-rich domain zf-Sec23_Sec24 PF04810.15 KOS21533.1 - 8.5 6.5 7.2 5.8 7.0 5.0 1.8 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Rad1 PF02144.16 KOS21534.1 - 3.1e-71 239.7 0.0 3.6e-71 239.5 0.0 1.0 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 BAR PF03114.18 KOS21536.1 - 5.6e-68 229.1 5.6 6.8e-68 228.9 5.6 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 KOS21536.1 - 2.5e-15 55.8 0.0 5.5e-15 54.7 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS21536.1 - 5.4e-11 42.2 0.0 1.1e-10 41.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOS21536.1 - 2.2e-07 30.4 0.1 9.3e-07 28.4 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain CT_C_D PF02682.16 KOS21536.1 - 0.15 11.8 0.5 0.54 10.0 0.1 2.0 3 0 0 3 3 3 0 Carboxyltransferase domain, subdomain C and D TMPIT PF07851.13 KOS21536.1 - 0.4 9.9 4.7 1.1 8.5 0.1 2.1 1 1 1 2 2 2 0 TMPIT-like protein Vps5 PF09325.10 KOS21536.1 - 1.3 8.5 8.4 11 5.5 8.4 2.0 1 1 0 1 1 1 0 Vps5 C terminal like Aminotran_5 PF00266.19 KOS21537.1 - 2.3e-92 309.8 0.0 2.8e-92 309.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 KOS21537.1 - 2.5e-06 27.0 0.0 2.3e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Beta_elim_lyase PF01212.21 KOS21537.1 - 6.6e-06 25.6 0.1 1.1e-05 24.9 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Pyridoxal_deC PF00282.19 KOS21537.1 - 0.0099 14.6 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 KOS21537.1 - 0.021 13.4 0.0 0.03 12.8 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Aft1_HRA PF11786.8 KOS21538.1 - 7.6 6.9 6.1 29 5.1 6.1 2.0 1 1 0 1 1 1 0 Aft1 HRA domain F-box-like PF12937.7 KOS21540.1 - 4.8e-10 39.2 0.2 9.6e-10 38.2 0.2 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS21540.1 - 1e-07 31.6 0.3 2.1e-07 30.6 0.3 1.5 1 0 0 1 1 1 1 F-box domain UIM PF02809.20 KOS21540.1 - 0.0076 16.1 12.6 0.46 10.5 4.6 3.1 2 0 0 2 2 2 2 Ubiquitin interaction motif Clr2 PF10383.9 KOS21542.1 - 1.1e-08 36.0 4.7 7.5e-08 33.3 0.0 3.5 3 1 0 3 3 3 1 Transcription-silencing protein Clr2 Clr2_transil PF16761.5 KOS21542.1 - 2e-06 28.5 4.4 6.7e-06 26.8 4.4 1.9 1 1 0 1 1 1 1 Transcription-silencing protein, cryptic loci regulator Clr2 TFIIA PF03153.13 KOS21542.1 - 0.018 15.1 7.5 0.025 14.6 7.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Zn_ribbon_17 PF17120.5 KOS21543.1 - 0.0062 16.1 3.8 0.0062 16.1 3.8 2.8 3 0 0 3 3 3 2 Zinc-ribbon, C4HC2 type PHA_gran_rgn PF09650.10 KOS21543.1 - 0.24 11.7 0.8 11 6.3 0.1 2.5 2 0 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) FYVE_2 PF02318.16 KOS21543.1 - 0.47 10.7 20.2 3.7 7.8 1.4 3.4 3 1 0 3 3 3 0 FYVE-type zinc finger Baculo_PEP_C PF04513.12 KOS21544.1 - 0.21 11.6 0.0 0.4 10.7 0.0 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus SMC_Nse1 PF07574.13 KOS21545.1 - 5e-64 215.8 0.0 6.5e-64 215.4 0.0 1.1 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 KOS21545.1 - 3.1e-16 59.4 8.1 6e-16 58.5 8.1 1.5 1 0 0 1 1 1 1 RING-like domain zf-HC5HC2H PF13771.6 KOS21545.1 - 0.54 10.5 5.7 1.6 9.0 5.7 1.7 1 1 1 2 2 2 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 KOS21545.1 - 3.6 8.0 7.6 6.9 7.1 7.6 1.5 1 0 0 1 1 1 0 Ring finger domain CAP_N PF01213.19 KOS21546.1 - 2.4 7.6 5.1 4 6.8 5.1 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SPRY PF00622.28 KOS21547.1 - 0.00098 19.2 0.0 0.013 15.7 0.0 2.7 4 0 0 4 4 4 1 SPRY domain DUF4169 PF13770.6 KOS21547.1 - 2.8 8.3 5.7 6 7.2 5.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) Trehalase PF01204.18 KOS21548.1 - 4.2e-191 636.2 0.0 5.2e-191 635.9 0.0 1.1 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 KOS21548.1 - 2.1e-17 62.5 0.6 4.2e-17 61.6 0.6 1.5 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain Yippee-Mis18 PF03226.14 KOS21549.1 - 1.4e-15 57.4 0.0 2.3e-15 56.7 0.0 1.3 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF4834 PF16118.5 KOS21549.1 - 0.0017 19.2 3.0 0.02 15.9 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) ECSCR PF15820.5 KOS21549.1 - 0.0044 16.8 1.7 0.0096 15.7 1.7 1.5 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator Tmemb_9 PF05434.11 KOS21549.1 - 0.019 14.9 0.0 0.04 13.8 0.0 1.6 1 0 0 1 1 1 0 TMEM9 DUF929 PF06053.11 KOS21549.1 - 0.075 12.3 1.5 0.11 11.8 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) EphA2_TM PF14575.6 KOS21549.1 - 0.078 13.9 1.2 0.18 12.7 0.5 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RIG-I_C-RD PF11648.8 KOS21549.1 - 0.1 12.8 0.1 0.42 10.9 0.0 1.9 2 0 0 2 2 2 0 C-terminal domain of RIG-I Polysacc_syn_2C PF08485.10 KOS21549.1 - 0.39 10.5 0.9 0.79 9.5 0.9 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein C-terminal DUF3139 PF11337.8 KOS21549.1 - 2.7 8.7 10.2 5 7.8 10.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Bul1_C PF04426.12 KOS21550.1 - 1.2e-10 41.2 1.7 5.8e-09 35.8 0.5 2.2 2 0 0 2 2 2 1 Bul1 C terminus Arrestin_N PF00339.29 KOS21550.1 - 2.6e-05 24.3 0.6 0.00023 21.2 0.0 2.8 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Period_C PF12114.8 KOS21550.1 - 0.00042 20.0 9.4 0.00085 19.0 9.4 1.4 1 0 0 1 1 1 1 Period protein 2/3C-terminal region Bul1_N PF04425.12 KOS21550.1 - 0.0036 16.1 8.6 0.082 11.7 0.2 3.6 3 1 1 4 4 4 2 Bul1 N terminus FmiP_Thoc5 PF09766.9 KOS21550.1 - 0.005 16.2 1.0 0.0076 15.6 1.0 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 Arrestin_C PF02752.22 KOS21550.1 - 0.021 15.3 1.6 0.069 13.6 0.1 2.5 3 0 0 3 3 3 0 Arrestin (or S-antigen), C-terminal domain Peptidase_S49_N PF08496.10 KOS21550.1 - 0.025 14.7 0.2 0.044 13.9 0.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 KOS21550.1 - 0.26 11.1 2.6 0.36 10.6 2.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CCDC106 PF15794.5 KOS21550.1 - 0.29 10.8 12.1 0.53 10.0 12.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 KOS21550.1 - 0.5 9.1 1.8 0.67 8.7 1.8 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 KOS21550.1 - 0.72 8.3 7.8 0.98 7.9 7.8 1.2 1 0 0 1 1 1 0 Macoilin family FAM199X PF15814.5 KOS21550.1 - 5.2 6.0 16.0 0.51 9.3 11.2 1.7 2 0 0 2 2 2 0 Protein family FAM199X CDC45 PF02724.14 KOS21550.1 - 6.1 5.0 8.7 8.6 4.5 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4614 PF15391.6 KOS21550.1 - 6.5 6.7 13.6 16 5.5 13.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 KOS21550.1 - 9.1 5.0 10.8 13 4.5 10.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Pyridoxal_deC PF00282.19 KOS21551.1 - 1.8e-98 329.7 0.0 2.6e-98 329.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain cNMP_binding PF00027.29 KOS21552.1 - 2.3e-32 110.9 0.7 8.2e-15 54.7 0.0 5.5 5 0 0 5 5 5 3 Cyclic nucleotide-binding domain Patatin PF01734.22 KOS21552.1 - 8.6e-16 58.7 7.4 3.2e-14 53.6 5.5 3.3 2 1 0 2 2 2 1 Patatin-like phospholipase ATP_bind_1 PF03029.17 KOS21553.1 - 2.2e-75 253.6 0.1 4.2e-75 252.6 0.0 1.5 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 KOS21553.1 - 0.0048 15.9 0.0 0.0081 15.2 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB Zeta_toxin PF06414.12 KOS21553.1 - 0.036 13.3 0.1 0.094 12.0 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin AAA_29 PF13555.6 KOS21553.1 - 0.053 13.3 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Phage_cap_E PF03864.15 KOS21553.1 - 0.13 11.4 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Phage major capsid protein E RNase_P_Rpp14 PF01900.19 KOS21554.1 - 4.5e-38 129.6 0.0 6.3e-38 129.2 0.0 1.2 1 0 0 1 1 1 1 Rpp14/Pop5 family DDDD PF10161.9 KOS21554.1 - 0.27 11.0 2.6 0.62 9.9 2.6 1.6 1 0 0 1 1 1 0 Putative mitochondrial precursor protein NOA36 PF06524.12 KOS21554.1 - 1.3 8.3 5.6 1.6 8.0 5.6 1.2 1 0 0 1 1 1 0 NOA36 protein MoCF_biosynth PF00994.24 KOS21555.1 - 3e-54 182.6 0.7 6.5e-26 90.7 0.1 2.3 2 0 0 2 2 2 2 Probable molybdopterin binding domain MoeA_N PF03453.17 KOS21555.1 - 4.3e-40 137.0 3.4 7.4e-40 136.3 3.4 1.4 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) MoeA_C PF03454.15 KOS21555.1 - 6.4e-15 55.1 0.1 1.9e-14 53.6 0.1 1.9 1 0 0 1 1 1 1 MoeA C-terminal region (domain IV) ATP-synt_C PF00137.21 KOS21556.1 - 4.6e-24 84.5 34.1 1.5e-15 57.3 11.6 2.8 3 0 0 3 3 3 2 ATP synthase subunit C SLATT_5 PF18160.1 KOS21556.1 - 0.3 10.4 0.1 0.3 10.4 0.1 2.0 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 TFIIA_gamma_C PF02751.14 KOS21557.1 - 7.6e-25 86.8 1.5 1.1e-24 86.3 1.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 KOS21557.1 - 6.5e-24 83.7 0.2 9e-24 83.2 0.2 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain Rubrerythrin PF02915.17 KOS21557.1 - 0.11 12.9 0.0 0.15 12.5 0.0 1.1 1 0 0 1 1 1 0 Rubrerythrin EamA PF00892.20 KOS21558.1 - 0.0011 19.2 14.6 0.01 16.0 14.6 2.0 1 1 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 KOS21558.1 - 0.0017 18.3 1.0 0.0022 18.0 1.0 1.2 1 0 0 1 1 1 1 Putative transmembrane family 234 Voltage_CLC PF00654.20 KOS21559.1 - 6.4e-89 298.7 29.8 6.4e-89 298.7 29.8 1.7 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 KOS21559.1 - 2.7e-12 46.9 0.0 0.00013 22.4 0.0 2.5 2 0 0 2 2 2 2 CBS domain Abhydrolase_6 PF12697.7 KOS21560.1 - 0.00029 21.5 4.1 0.00029 21.5 4.1 1.7 2 0 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS21560.1 - 0.014 14.7 0.1 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS21560.1 - 0.021 14.5 0.1 0.35 10.5 0.1 2.3 1 1 1 2 2 2 0 alpha/beta hydrolase fold AXE1 PF05448.12 KOS21560.1 - 0.12 11.0 0.0 0.21 10.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DAO PF01266.24 KOS21561.1 - 6.7e-44 150.9 3.8 7.9e-44 150.7 3.8 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS21561.1 - 0.00034 20.8 0.0 0.00084 19.5 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOS21561.1 - 0.003 16.3 0.4 0.065 11.9 0.2 2.1 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 KOS21561.1 - 0.0037 16.6 0.1 0.0081 15.4 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS21561.1 - 0.008 15.3 1.8 0.027 13.5 1.8 2.0 1 1 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 KOS21561.1 - 0.0093 15.2 0.1 0.014 14.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KOS21561.1 - 0.013 14.7 0.0 0.023 13.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Pyr_redox_3 PF13738.6 KOS21561.1 - 0.026 13.8 0.0 4 6.6 0.0 2.1 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOS21561.1 - 0.037 13.4 0.0 0.05 12.9 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOS21561.1 - 0.048 13.7 0.7 5.2 7.0 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 KOS21561.1 - 0.083 12.2 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_4 PF07993.12 KOS21562.1 - 3.4e-32 111.6 0.1 2.9e-29 102.0 0.1 2.5 1 1 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 KOS21562.1 - 6.8e-18 65.0 0.0 9.2e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 KOS21562.1 - 3.1e-11 43.5 0.0 7e-11 42.3 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 KOS21562.1 - 1.7e-05 24.0 0.0 2.4e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 KOS21562.1 - 0.00014 21.4 0.0 0.00027 20.5 0.0 1.5 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase AMP-binding PF00501.28 KOS21562.1 - 0.034 12.8 0.8 0.051 12.2 0.8 1.2 1 0 0 1 1 1 0 AMP-binding enzyme AMP-binding_C PF13193.6 KOS21562.1 - 0.036 15.0 0.1 0.29 12.2 0.0 2.3 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain ComX PF05952.12 KOS21562.1 - 0.19 11.7 0.3 14 5.7 0.1 3.3 3 0 0 3 3 3 0 Bacillus competence pheromone ComX RRP7 PF12923.7 KOS21563.1 - 9.4e-30 103.2 15.1 9.4e-30 103.2 15.1 1.6 2 0 0 2 2 2 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain RRM_Rrp7 PF17799.1 KOS21563.1 - 0.003 17.4 0.0 0.0066 16.3 0.0 1.6 1 0 0 1 1 1 1 Rrp7 RRM-like N-terminal domain Adenylsucc_synt PF00709.21 KOS21564.1 - 3.1e-141 471.1 0.0 5.5e-140 467.0 0.0 1.9 1 1 0 1 1 1 1 Adenylosuccinate synthetase UvrA_DNA-bind PF17755.1 KOS21564.1 - 0.055 13.8 0.0 9.8 6.6 0.0 2.3 2 0 0 2 2 2 0 UvrA DNA-binding domain DUF92 PF01940.16 KOS21566.1 - 1.6e-88 296.1 2.4 2e-88 295.8 2.4 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF92 ADIP PF11559.8 KOS21567.1 - 1.1e-36 126.2 5.8 1.1e-36 126.2 5.8 2.4 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Golgin_A5 PF09787.9 KOS21567.1 - 0.00066 19.2 2.7 0.00066 19.2 2.7 2.3 3 0 0 3 3 3 1 Golgin subfamily A member 5 TPR_MLP1_2 PF07926.12 KOS21567.1 - 0.0033 17.5 9.9 0.0033 17.5 9.9 3.4 5 0 0 5 5 5 1 TPR/MLP1/MLP2-like protein TTKRSYEDQ PF10212.9 KOS21567.1 - 0.059 12.4 1.0 0.12 11.4 1.0 1.4 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein Laminin_II PF06009.12 KOS21567.1 - 0.65 10.0 8.6 0.36 10.8 5.8 2.0 2 0 0 2 2 2 0 Laminin Domain II KxDL PF10241.9 KOS21567.1 - 1.1 9.5 4.9 1 9.7 0.6 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein Spc7 PF08317.11 KOS21567.1 - 2.2 7.1 10.4 1.1 8.0 5.3 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein DEAD PF00270.29 KOS21568.1 - 4.2e-34 117.8 0.0 8.3e-33 113.6 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS21568.1 - 3.5e-26 91.7 0.1 1e-25 90.3 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS21568.1 - 0.0024 17.9 0.0 0.0049 16.9 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 KOS21568.1 - 0.057 13.6 0.1 0.31 11.2 0.0 2.1 2 0 0 2 2 2 0 Helicase C-terminal domain CMS1 PF14617.6 KOS21568.1 - 0.08 12.3 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 KOS21568.1 - 0.11 12.8 0.0 0.66 10.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 KOS21568.1 - 0.22 11.8 0.5 2.1 8.6 0.5 2.5 2 1 0 2 2 2 0 AAA domain Snf7 PF03357.21 KOS21570.1 - 4.9e-32 110.9 19.2 4.9e-32 110.9 19.2 2.0 1 1 1 2 2 2 1 Snf7 DUF3138 PF11336.8 KOS21570.1 - 0.039 12.6 7.0 0.076 11.6 3.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Allexi_40kDa PF05549.11 KOS21570.1 - 0.061 12.8 5.6 0.084 12.4 5.2 1.5 1 1 0 1 1 1 0 Allexivirus 40kDa protein zf-C4H2 PF10146.9 KOS21570.1 - 0.63 10.3 17.4 2.1 8.6 17.4 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein HhH-GPD PF00730.25 KOS21571.1 - 1.6e-14 54.2 0.0 3.2e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein LRR_5 PF13306.6 KOS21572.1 - 0.018 15.0 4.7 0.041 13.9 0.0 2.5 2 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Sugar_tr PF00083.24 KOS21573.1 - 2.9e-127 425.3 18.2 3.3e-127 425.1 18.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS21573.1 - 5.6e-24 84.7 31.2 3.3e-19 69.0 8.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily IMUP PF15761.5 KOS21573.1 - 0.56 10.9 7.6 0.99 10.1 7.6 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein CcmD PF04995.14 KOS21573.1 - 5.4 7.2 10.6 1.7 8.8 6.5 2.4 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) FAD_binding_2 PF00890.24 KOS21574.1 - 5.8e-84 282.6 0.6 7.2e-84 282.3 0.6 1.1 1 0 0 1 1 1 1 FAD binding domain Cyt-b5 PF00173.28 KOS21574.1 - 3.7e-21 75.1 0.1 7.7e-20 70.8 0.0 2.8 3 0 0 3 3 3 1 Cytochrome b5-like Heme/Steroid binding domain DAO PF01266.24 KOS21574.1 - 9.1e-14 51.8 0.3 1.6e-13 51.0 0.3 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 KOS21574.1 - 1.5e-10 41.0 0.5 1e-09 38.3 0.5 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS21574.1 - 4.5e-08 32.7 0.2 5.3e-07 29.2 0.1 2.5 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 KOS21574.1 - 7.4e-08 32.5 2.9 5.2e-07 29.8 0.8 3.0 2 1 1 3 3 3 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOS21574.1 - 3.1e-06 26.7 0.0 0.05 12.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 KOS21574.1 - 9.1e-06 25.1 0.3 1.8e-05 24.2 0.3 1.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOS21574.1 - 1.1e-05 24.4 3.1 0.008 14.9 0.4 3.3 3 0 0 3 3 3 2 HI0933-like protein GIDA PF01134.22 KOS21574.1 - 0.00026 20.2 2.6 0.018 14.1 0.8 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Amino_oxidase PF01593.24 KOS21574.1 - 0.00063 19.1 0.7 0.85 8.8 0.2 2.8 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Thi4 PF01946.17 KOS21574.1 - 0.0011 18.2 1.2 0.061 12.6 0.4 2.3 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 KOS21574.1 - 0.02 15.5 2.4 2.9 8.5 0.5 2.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS21574.1 - 0.074 12.3 0.5 0.15 11.4 0.5 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CPSF_A PF03178.15 KOS21575.1 - 6e-75 252.5 0.0 1.5e-74 251.2 0.0 1.7 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 KOS21575.1 - 1.7e-15 56.6 0.0 4e-15 55.4 0.0 1.6 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Pal1 PF08316.11 KOS21576.1 - 1.1e-06 29.5 0.1 1.8e-06 28.7 0.1 1.3 1 0 0 1 1 1 1 Pal1 cell morphology protein DUF4490 PF14892.6 KOS21576.1 - 0.18 11.9 0.0 0.4 10.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4490) SR-25 PF10500.9 KOS21576.1 - 3.1 7.3 7.3 5.4 6.6 7.3 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF761 PF05553.11 KOS21577.1 - 0.00021 20.7 2.3 0.00053 19.5 2.3 1.6 1 0 0 1 1 1 1 Cotton fibre expressed protein zf-MYND PF01753.18 KOS21577.1 - 0.34 11.0 3.8 0.7 10.0 3.8 1.5 1 0 0 1 1 1 0 MYND finger zf-HIT PF04438.16 KOS21577.1 - 0.43 10.5 4.1 0.97 9.4 4.1 1.5 1 0 0 1 1 1 0 HIT zinc finger DUF5349 PF17298.2 KOS21577.1 - 2.7 7.7 5.4 3.4 7.3 5.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) LMBR1 PF04791.16 KOS21578.1 - 5.5e-17 61.9 27.7 8e-17 61.3 6.5 2.6 2 1 1 3 3 3 2 LMBR1-like membrane protein DUF3591 PF12157.8 KOS21579.1 - 5.9e-170 565.7 0.3 9.3e-170 565.0 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3591) zf-CCHC PF00098.23 KOS21579.1 - 0.0044 17.0 0.7 0.0087 16.1 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_6 PF15288.6 KOS21579.1 - 0.038 13.8 0.4 0.09 12.6 0.4 1.7 1 0 0 1 1 1 0 Zinc knuckle SRF-TF PF00319.18 KOS21582.1 - 8.1e-23 79.7 0.3 1.3e-22 79.1 0.3 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) PP2C PF00481.21 KOS21583.1 - 1.4e-84 283.8 0.0 2.1e-84 283.2 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 KOS21583.1 - 0.0048 16.8 0.0 0.062 13.2 0.0 2.1 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) baeRF_family12 PF18856.1 KOS21583.1 - 0.056 14.0 1.0 0.13 12.8 1.0 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 PP2C_2 PF13672.6 KOS21583.1 - 0.096 12.3 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein phosphatase 2C PPR_2 PF13041.6 KOS21584.1 - 4.4e-09 36.4 0.0 0.00029 20.9 0.0 3.4 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 KOS21584.1 - 0.01 15.9 0.0 0.13 12.4 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain DUF4476 PF14771.6 KOS21585.1 - 0.051 13.9 0.1 0.084 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4476) Methyltransf_16 PF10294.9 KOS21587.1 - 2.2e-25 89.4 1.6 8.4e-23 81.0 0.1 2.1 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 KOS21587.1 - 0.0017 17.9 0.1 0.0026 17.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain DUF2920 PF11144.8 KOS21587.1 - 0.13 11.4 0.0 0.16 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) PrmA PF06325.13 KOS21587.1 - 0.19 11.1 0.1 0.26 10.6 0.1 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Adeno_PV PF03910.13 KOS21588.1 - 0.95 8.1 6.2 0.49 9.1 3.2 1.8 2 0 0 2 2 2 0 Adenovirus minor core protein PV He_PIG PF05345.12 KOS21590.1 - 8.7e-10 38.6 3.1 0.00025 21.2 0.2 2.7 2 1 0 2 2 2 2 Putative Ig domain DUF1712 PF08217.11 KOS21591.1 - 1.2e-10 40.5 0.0 2.1e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) DPBB_1 PF03330.18 KOS21592.1 - 1.8e-05 24.9 0.5 5.7e-05 23.3 0.2 2.1 2 1 0 2 2 2 1 Lytic transglycolase MCM PF00493.23 KOS21593.1 - 1.2e-97 325.5 0.1 1.8e-97 324.8 0.1 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 KOS21593.1 - 3.5e-31 107.7 0.1 6.3e-31 106.8 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_N PF14551.6 KOS21593.1 - 2.5e-12 47.3 0.1 6e-12 46.1 0.1 1.6 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 KOS21593.1 - 1.5e-07 31.0 0.0 2.4e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 KOS21593.1 - 0.0017 18.2 0.0 0.0058 16.5 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 KOS21593.1 - 0.0065 16.2 0.0 0.02 14.6 0.0 1.8 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 KOS21593.1 - 0.066 13.2 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Ras PF00071.22 KOS21594.1 - 1.9e-32 112.1 0.0 4.3e-32 110.9 0.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 KOS21594.1 - 2e-06 28.0 0.0 2.7e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Oxysterol_BP PF01237.18 KOS21595.1 - 2.7e-110 368.7 0.0 7.7e-110 367.2 0.0 1.8 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 KOS21595.1 - 3.2e-36 123.5 0.1 1.9e-35 121.0 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 KOS21595.1 - 8.3e-06 26.3 0.0 2.6e-05 24.7 0.0 1.9 1 0 0 1 1 1 1 PH domain LIM_bind PF01803.16 KOS21595.1 - 0.083 12.4 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 LIM-domain binding protein Glyco_hydro_72 PF03198.14 KOS21596.1 - 5.4e-125 416.8 0.5 7.4e-125 416.4 0.5 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 KOS21596.1 - 1.2e-05 24.9 0.5 7.7e-05 22.3 0.5 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) ODC_AZ PF02100.17 KOS21597.1 - 4.3e-43 145.9 0.1 5.1e-43 145.7 0.1 1.1 1 0 0 1 1 1 1 Ornithine decarboxylase antizyme Tfb5 PF06331.12 KOS21598.1 - 3.7e-26 90.9 0.8 3.9e-26 90.8 0.8 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 BLYB PF05289.11 KOS21598.1 - 0.02 15.1 1.4 0.022 15.0 1.4 1.0 1 0 0 1 1 1 0 Borrelia hemolysin accessory protein TFIIIC_sub6 PF10419.9 KOS21599.1 - 3.6e-22 78.0 0.0 8.9e-22 76.8 0.0 1.6 1 1 0 1 1 1 1 TFIIIC subunit triple barrel domain His_biosynth PF00977.21 KOS21600.1 - 3.4e-45 154.3 0.0 1.4e-44 152.3 0.0 2.0 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 KOS21600.1 - 7.1e-19 68.3 0.0 1.2e-18 67.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 KOS21600.1 - 5.7e-07 29.3 0.0 1.2e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 KOS21600.1 - 1.1e-06 28.6 0.0 6.9e-06 26.0 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Dus PF01207.17 KOS21600.1 - 0.017 14.2 0.0 0.077 12.1 0.0 1.9 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) Peptidase_C26 PF07722.13 KOS21600.1 - 0.046 13.5 0.1 0.43 10.3 0.0 2.1 2 0 0 2 2 2 0 Peptidase C26 GST_C_6 PF17171.4 KOS21601.1 - 4.1e-13 48.9 0.1 7.6e-13 48.1 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 KOS21601.1 - 0.0078 16.9 0.0 0.029 15.1 0.0 1.8 1 1 1 2 2 2 1 Glutathione S-transferase N-terminal domain GST_C_2 PF13410.6 KOS21601.1 - 0.022 14.8 1.8 0.042 13.9 1.8 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 KOS21601.1 - 0.03 14.6 0.0 0.062 13.6 0.0 1.5 1 1 0 1 1 1 0 Outer mitochondrial membrane transport complex protein SAM35 PF10806.8 KOS21601.1 - 0.22 11.8 0.0 0.31 11.3 0.0 1.2 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex CLTH PF10607.9 KOS21602.1 - 6e-30 104.1 0.0 1.2e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain SPRY PF00622.28 KOS21602.1 - 1.2e-15 57.7 0.0 2.6e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 SPRY domain LisH PF08513.11 KOS21602.1 - 2.2e-05 24.2 0.1 8.5e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 LisH SMC_ScpB PF04079.16 KOS21602.1 - 0.063 12.9 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB PigN PF04987.14 KOS21603.1 - 7.8e-71 239.3 7.7 1e-70 238.9 7.7 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) DUF2721 PF11026.8 KOS21603.1 - 1.1 9.2 8.8 0.067 13.1 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) TFIIA PF03153.13 KOS21604.1 - 0.00015 22.0 11.6 0.00015 22.0 11.6 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Peptidase_M1 PF01433.20 KOS21604.1 - 0.0019 17.8 0.1 0.0019 17.8 0.1 2.2 2 1 0 2 2 2 1 Peptidase family M1 domain HEAT_2 PF13646.6 KOS21604.1 - 0.0085 16.5 0.0 1.5 9.3 0.0 3.4 3 0 0 3 3 3 1 HEAT repeats Peptidase_M1_N PF17900.1 KOS21604.1 - 0.048 13.8 9.9 0.13 12.5 0.0 3.0 3 0 0 3 3 3 0 Peptidase M1 N-terminal domain DUF4770 PF15994.5 KOS21604.1 - 0.23 11.7 7.4 0.89 9.8 7.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF2722 PF10846.8 KOS21604.1 - 0.4 9.6 18.0 0.73 8.7 18.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Presenilin PF01080.17 KOS21604.1 - 0.66 8.7 3.7 1 8.0 3.7 1.2 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 KOS21604.1 - 0.88 9.0 4.9 1.6 8.1 4.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 KOS21604.1 - 9.4 6.9 29.2 4.6 7.9 2.1 2.5 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region BAR_2 PF10455.9 KOS21605.1 - 4.1e-50 170.5 0.0 6e-50 170.0 0.0 1.2 1 0 0 1 1 1 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 KOS21605.1 - 2.7e-16 60.0 1.6 8.8e-15 55.0 1.6 2.1 1 1 0 1 1 1 1 BAR domain BAR_3 PF16746.5 KOS21605.1 - 0.0017 18.1 0.6 0.054 13.2 0.1 2.4 2 1 0 2 2 2 1 BAR domain of APPL family DUF488 PF04343.13 KOS21605.1 - 0.0091 16.6 0.4 0.045 14.3 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function, DUF488 SHE3 PF17078.5 KOS21605.1 - 0.13 11.9 3.0 0.1 12.3 0.6 1.9 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Podoplanin PF05808.11 KOS21606.1 - 1.3 9.1 6.0 1.7 8.7 6.0 1.3 1 1 0 1 1 1 0 Podoplanin MFS_1 PF07690.16 KOS21608.1 - 9.9e-05 21.4 37.3 0.11 11.4 0.1 3.2 2 1 0 2 2 2 2 Major Facilitator Superfamily Pkinase PF00069.25 KOS21610.1 - 9e-53 179.3 0.0 1.2e-52 178.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21610.1 - 5.8e-20 71.7 0.2 1.5e-19 70.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 KOS21610.1 - 0.048 13.6 0.0 0.099 12.5 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pex24p PF06398.11 KOS21611.1 - 3.7e-83 279.5 0.0 5.1e-83 279.1 0.0 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DUF3292 PF11696.8 KOS21611.1 - 0.068 11.5 0.2 0.14 10.5 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3292) Reticulon PF02453.17 KOS21611.1 - 0.069 13.1 0.1 0.12 12.4 0.1 1.4 1 1 0 1 1 1 0 Reticulon polyprenyl_synt PF00348.17 KOS21612.1 - 7.1e-61 205.5 0.0 8.6e-61 205.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase CDC14 PF08045.11 KOS21613.1 - 8.5e-110 366.3 0.1 9.9e-109 362.8 0.0 1.9 1 1 1 2 2 2 2 Cell division control protein 14, SIN component CCDC53 PF10152.9 KOS21613.1 - 0.044 14.2 0.0 0.075 13.4 0.0 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex IDO PF01231.18 KOS21615.1 - 1.5e-29 103.1 0.0 2.2e-29 102.5 0.0 1.3 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase PTE PF02126.18 KOS21615.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotriesterase family INO80_Ies4 PF08193.11 KOS21616.1 - 1.2e-70 238.2 18.7 1.5e-70 237.9 18.7 1.1 1 0 0 1 1 1 1 INO80 complex subunit Ies4 ER_lumen_recept PF00810.18 KOS21617.1 - 2e-40 139.0 9.6 2.8e-40 138.5 9.6 1.2 1 0 0 1 1 1 1 ER lumen protein retaining receptor PQ-loop PF04193.14 KOS21617.1 - 0.27 11.0 0.0 0.27 11.0 0.0 2.8 3 0 0 3 3 3 0 PQ loop repeat LicD PF04991.13 KOS21618.1 - 1.9e-12 47.8 1.9 1.7e-05 25.0 0.0 3.1 2 1 1 3 3 3 3 LicD family DUF3152 PF11350.8 KOS21618.1 - 0.18 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3152) LETM1 PF07766.13 KOS21619.1 - 5.1e-101 337.5 0.1 5.1e-101 337.5 0.1 1.5 2 0 0 2 2 2 1 LETM1-like protein SAP PF02037.27 KOS21619.1 - 0.033 14.0 0.0 0.67 9.8 0.0 2.6 3 0 0 3 3 3 0 SAP domain FSA_C PF10479.9 KOS21619.1 - 0.47 8.5 2.8 0.65 8.1 2.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus ADK PF00406.22 KOS21620.1 - 9e-34 116.8 0.0 2.8e-18 66.5 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 KOS21620.1 - 1.1e-14 54.1 0.1 1.8e-14 53.4 0.1 1.3 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_17 PF13207.6 KOS21620.1 - 3.6e-13 50.1 0.0 8.1e-10 39.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 KOS21620.1 - 0.00016 22.2 0.0 0.0061 17.1 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 KOS21620.1 - 0.0057 16.8 0.1 0.013 15.6 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 KOS21620.1 - 0.084 12.9 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_S8 PF00082.22 KOS21621.1 - 1.8e-36 126.0 0.3 3.2e-36 125.1 0.3 1.4 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 KOS21621.1 - 3.8e-28 97.3 0.8 8.2e-28 96.3 0.8 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain S8_pro-domain PF16470.5 KOS21621.1 - 0.047 14.5 0.4 0.11 13.3 0.4 1.6 1 0 0 1 1 1 0 Peptidase S8 pro-domain PX PF00787.24 KOS21622.1 - 3.5e-19 68.9 1.8 3.6e-19 68.8 0.4 1.8 2 0 0 2 2 2 1 PX domain Vps5 PF09325.10 KOS21622.1 - 1.1e-08 34.9 5.4 5.5e-05 22.8 0.3 2.4 2 0 0 2 2 2 2 Vps5 C terminal like BAR PF03114.18 KOS21622.1 - 0.0024 17.6 5.8 0.035 13.8 1.6 2.3 2 1 0 2 2 2 2 BAR domain Sec34 PF04136.15 KOS21622.1 - 0.017 15.0 0.3 0.06 13.2 0.0 2.1 2 1 0 2 2 2 0 Sec34-like family AlkA_N PF06029.11 KOS21622.1 - 0.024 14.9 0.3 0.081 13.2 0.3 2.0 1 0 0 1 1 1 0 AlkA N-terminal domain Occludin_ELL PF07303.13 KOS21622.1 - 0.029 15.1 1.0 0.94 10.2 0.0 3.4 4 0 0 4 4 4 0 Occludin homology domain CENP-H PF05837.12 KOS21622.1 - 0.072 13.5 3.1 1.6 9.1 0.0 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DUF3140 PF11338.8 KOS21622.1 - 0.091 13.2 1.5 0.17 12.3 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3140) DUF1664 PF07889.12 KOS21622.1 - 1.2 9.1 4.5 19 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) GreA_GreB_N PF03449.15 KOS21622.1 - 1.6 8.9 7.1 0.48 10.6 1.6 2.6 2 0 0 2 2 2 0 Transcription elongation factor, N-terminal Spc7 PF08317.11 KOS21622.1 - 3.3 6.5 9.3 0.15 10.9 3.3 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein bZIP_2 PF07716.15 KOS21622.1 - 3.8 7.7 12.6 0.23 11.6 1.8 3.1 3 0 0 3 3 3 0 Basic region leucine zipper RCR PF12273.8 KOS21623.1 - 0.00024 21.7 0.1 0.00047 20.8 0.1 1.6 1 1 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red PsbY PF06298.11 KOS21623.1 - 0.78 9.7 7.4 1.4 8.8 7.4 1.4 1 0 0 1 1 1 0 Photosystem II protein Y (PsbY) FeoB_associated PF12669.7 KOS21623.1 - 5.1 7.6 4.7 8.5 6.9 4.7 1.3 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein TPMT PF05724.11 KOS21624.1 - 9.7e-30 103.8 0.0 1.3e-28 100.2 0.0 2.2 2 1 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_11 PF08241.12 KOS21624.1 - 1.2e-08 35.5 0.0 6.3e-08 33.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS21624.1 - 1.4e-08 34.8 0.0 1.9e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS21624.1 - 3.1e-08 33.6 0.0 2.7e-07 30.5 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS21624.1 - 5.2e-07 30.3 0.0 3.8e-06 27.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS21624.1 - 2.3e-06 28.3 0.0 4.5e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 KOS21624.1 - 0.0079 15.6 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB adh_short_C2 PF13561.6 KOS21625.1 - 2.6e-45 154.8 0.1 3.2e-45 154.5 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS21625.1 - 1.7e-37 128.8 0.0 2.3e-37 128.4 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase DUF1776 PF08643.10 KOS21625.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Peptidase_S8 PF00082.22 KOS21627.1 - 3.6e-31 108.5 10.1 7.8e-31 107.4 10.1 1.5 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 KOS21627.1 - 0.00013 22.6 0.1 0.00052 20.6 0.1 2.0 2 0 0 2 2 2 1 Peptidase inhibitor I9 LSM PF01423.22 KOS21628.1 - 1.2e-16 60.2 0.0 1.7e-16 59.7 0.0 1.2 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 KOS21628.1 - 0.016 15.3 0.0 0.02 15.0 0.0 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain SpoU_sub_bind PF08032.12 KOS21628.1 - 0.14 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding GRP PF07172.11 KOS21628.1 - 1.2 9.9 19.5 1.5 9.6 19.5 1.2 1 0 0 1 1 1 0 Glycine rich protein family PPR_2 PF13041.6 KOS21629.1 - 1.5e-08 34.7 0.0 0.045 13.9 0.0 4.8 4 0 0 4 4 4 2 PPR repeat family PPR_3 PF13812.6 KOS21629.1 - 2.4e-05 24.3 0.0 4.8 7.3 0.0 3.9 4 0 0 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.20 KOS21629.1 - 4.2e-05 23.5 1.3 0.65 10.4 0.0 5.0 5 0 0 5 5 5 2 PPR repeat PPR_long PF17177.4 KOS21629.1 - 0.002 17.5 0.7 0.08 12.3 0.0 2.8 3 0 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 KOS21629.1 - 0.084 12.6 0.3 0.99 9.2 0.1 2.8 2 0 0 2 2 2 0 PPR repeat Inositol_P PF00459.25 KOS21630.1 - 2.7e-64 217.3 0.0 3.5e-64 216.9 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family MFS_1 PF07690.16 KOS21631.1 - 7.3e-42 143.5 33.1 7.3e-42 143.5 33.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS21631.1 - 9e-11 41.3 0.1 9e-11 41.3 0.1 2.2 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KOS21631.1 - 0.00011 20.7 3.0 0.00011 20.7 3.0 1.4 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 KOS21631.1 - 0.0059 14.9 0.2 0.014 13.7 0.2 1.5 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family PLA2_B PF01735.18 KOS21632.1 - 3.3e-24 85.2 0.0 2.6e-23 82.2 0.0 1.9 1 1 0 1 1 1 1 Lysophospholipase catalytic domain Rhodanese PF00581.20 KOS21633.1 - 5.2e-13 49.4 0.0 7.7e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain RlmM_FDX PF18125.1 KOS21633.1 - 0.17 12.4 0.0 0.31 11.5 0.0 1.4 1 0 0 1 1 1 0 RlmM ferredoxin-like domain HET PF06985.11 KOS21634.1 - 1.3e-11 45.0 6.0 1.5e-09 38.4 0.3 2.4 1 1 1 2 2 2 2 Heterokaryon incompatibility protein (HET) S4 PF01479.25 KOS21635.1 - 1.9e-13 49.9 0.1 4e-13 48.8 0.1 1.6 1 0 0 1 1 1 1 S4 domain AbrB_C PF18277.1 KOS21635.1 - 0.011 15.4 2.0 1.5 8.5 0.0 3.1 3 0 0 3 3 3 0 AbrB C-terminal domain Pirin_C_2 PF17954.1 KOS21635.1 - 0.069 13.3 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain BCDHK_Adom3 PF10436.9 KOS21636.1 - 4.4e-45 153.4 0.0 5.7e-45 153.1 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 KOS21636.1 - 2.9e-12 47.1 0.0 2.5e-11 44.1 0.0 2.2 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Inhibitor_I9 PF05922.16 KOS21637.1 - 1.3e-07 32.2 0.1 3e-07 31.0 0.1 1.5 1 1 0 1 1 1 1 Peptidase inhibitor I9 Chitin_synth_2 PF03142.15 KOS21638.1 - 4.8e-247 820.7 0.7 6.5e-247 820.3 0.7 1.1 1 0 0 1 1 1 1 Chitin synthase Myosin_head PF00063.21 KOS21638.1 - 3e-77 260.4 0.0 8.6e-77 258.9 0.0 1.6 1 1 0 1 1 1 1 Myosin head (motor domain) DEK_C PF08766.11 KOS21638.1 - 3.3e-17 62.1 0.1 1.8e-16 59.8 0.3 2.1 2 0 0 2 2 2 1 DEK C terminal domain Glyco_trans_2_3 PF13632.6 KOS21638.1 - 5.7e-12 46.0 4.8 5.7e-12 46.0 4.8 1.9 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOS21638.1 - 3e-11 43.6 0.1 5.6e-10 39.5 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 KOS21638.1 - 1.8e-10 40.8 0.4 5.3e-07 29.7 0.1 3.8 4 0 0 4 4 4 1 Cytochrome b5-like Heme/Steroid binding domain Glycos_transf_2 PF00535.26 KOS21638.1 - 2.5e-05 24.2 0.0 0.023 14.5 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferase family 2 RsgA_GTPase PF03193.16 KOS21638.1 - 0.0028 17.6 0.0 0.0071 16.3 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 KOS21638.1 - 0.006 17.1 0.5 0.038 14.5 0.0 2.3 2 0 0 2 2 2 1 ABC transporter N-SET PF11764.8 KOS21638.1 - 0.0065 16.6 0.0 0.019 15.1 0.0 1.7 2 0 0 2 2 1 1 COMPASS (Complex proteins associated with Set1p) component N Glyco_transf_21 PF13506.6 KOS21638.1 - 0.043 13.3 0.2 0.23 10.9 0.2 2.1 1 1 0 1 1 1 0 Glycosyl transferase family 21 AAA_22 PF13401.6 KOS21638.1 - 0.061 13.6 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KOS21638.1 - 0.061 13.4 0.4 3.2 7.9 0.1 3.2 3 0 0 3 3 3 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 KOS21638.1 - 0.16 12.4 0.1 0.54 10.7 0.0 2.0 2 0 0 2 2 1 0 RNA helicase AAA_16 PF13191.6 KOS21638.1 - 0.16 12.3 0.0 0.53 10.7 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 KOS21638.1 - 0.17 11.1 0.0 0.28 10.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Chitin_synth_2 PF03142.15 KOS21639.1 - 4.1e-225 748.4 0.1 5.9e-225 747.9 0.1 1.1 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS21639.1 - 1.8e-15 57.4 3.5 4e-15 56.3 3.5 1.6 1 0 0 1 1 1 1 Glycosyl transferase family group 2 DEK_C PF08766.11 KOS21639.1 - 5.1e-15 55.1 0.9 4.4e-14 52.1 1.2 2.4 2 0 0 2 2 2 1 DEK C terminal domain Glyco_tranf_2_3 PF13641.6 KOS21639.1 - 2.1e-13 50.7 0.0 1.3e-12 48.1 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Cyt-b5 PF00173.28 KOS21639.1 - 2.5e-09 37.1 0.1 2.1e-05 24.5 0.1 2.9 2 1 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain Myosin_head PF00063.21 KOS21639.1 - 4.2e-08 31.9 0.0 1.4e-07 30.1 0.0 1.9 1 1 0 1 1 1 1 Myosin head (motor domain) Glyco_transf_21 PF13506.6 KOS21639.1 - 0.00069 19.1 0.0 0.0041 16.6 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 KOS21639.1 - 0.00073 19.4 0.0 0.16 11.8 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 Jiv90 PF14901.6 KOS21639.1 - 0.11 12.6 1.9 2.1 8.6 0.2 2.5 2 0 0 2 2 2 0 Cleavage inducing molecular chaperone Na_Ca_ex PF01699.24 KOS21640.1 - 6e-16 58.7 23.2 1.6e-15 57.4 10.9 2.9 2 1 0 2 2 2 2 Sodium/calcium exchanger protein DUF1298 PF06974.13 KOS21640.1 - 0.0022 18.0 0.0 0.0042 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) DUF3566 PF12089.8 KOS21640.1 - 0.05 14.0 3.4 0.092 13.1 1.2 2.3 1 1 1 2 2 2 0 Transmembrane domain of unknown function (DUF3566) DUF4234 PF14018.6 KOS21640.1 - 0.18 11.9 1.7 3.1 8.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4234) Chitin_synth_2 PF03142.15 KOS21641.1 - 7.5e-25 87.5 4.1 2.5e-22 79.2 2.5 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS21641.1 - 3.1e-15 56.6 5.9 3.1e-15 56.6 5.9 1.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOS21641.1 - 5e-11 42.9 0.0 1.6e-10 41.3 0.0 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 KOS21641.1 - 0.016 15.0 0.1 3.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Glycosyl transferase family 2 Abhydrolase_1 PF00561.20 KOS21642.1 - 3.4e-11 43.3 0.1 5.9e-11 42.5 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS21642.1 - 6.8e-11 43.2 0.7 1.1e-10 42.5 0.4 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS21642.1 - 1.1e-10 41.2 0.0 1.5e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 KOS21642.1 - 2.4e-06 27.6 0.1 3.8e-06 26.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 KOS21642.1 - 5.4e-05 22.9 0.1 7.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 KOS21642.1 - 0.007 15.9 0.0 0.013 15.0 0.0 1.4 1 0 0 1 1 1 1 Prolyl oligopeptidase family NMT_C PF02799.15 KOS21643.1 - 5.2e-80 267.9 0.1 7.3e-80 267.4 0.1 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 KOS21643.1 - 4e-71 238.0 0.2 4.3e-70 234.7 0.0 2.0 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 KOS21643.1 - 3e-05 24.1 0.1 0.00053 20.1 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS21643.1 - 0.0031 17.7 0.0 0.0067 16.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family SPT6_acidic PF14632.6 KOS21643.1 - 0.015 15.9 2.6 0.1 13.2 3.2 2.0 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Acetyltransf_7 PF13508.7 KOS21643.1 - 0.043 14.2 0.0 0.09 13.2 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 KOS21643.1 - 0.049 14.3 0.1 0.16 12.7 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain PGA2 PF07543.12 KOS21643.1 - 3.6 7.6 5.7 8.4 6.4 5.7 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 PX PF00787.24 KOS21644.1 - 1.9e-21 76.2 0.0 3.1e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 PX domain CK1gamma_C PF12605.8 KOS21645.1 - 4.4 8.5 10.0 3 9.1 0.1 3.2 3 0 0 3 3 3 0 Casein kinase 1 gamma C terminal Macoilin PF09726.9 KOS21646.1 - 0.14 10.7 29.9 0.16 10.5 29.9 1.0 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 KOS21646.1 - 0.21 9.8 19.3 0.25 9.6 19.3 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Apt1 PF10351.9 KOS21646.1 - 0.21 10.4 21.9 0.25 10.2 21.9 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 KOS21646.1 - 1.1 9.1 25.6 1.2 8.9 25.6 1.1 1 0 0 1 1 1 0 SPX domain Connexin PF00029.19 KOS21646.1 - 1.2 8.9 3.8 1.6 8.4 3.8 1.3 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 KOS21646.1 - 1.2 7.8 18.5 1.4 7.6 18.5 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 KOS21646.1 - 1.3 8.0 16.8 1.5 7.8 16.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PAP1 PF08601.10 KOS21646.1 - 1.3 8.6 26.0 1.5 8.4 26.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 Utp14 PF04615.13 KOS21646.1 - 2 6.9 15.4 2.2 6.7 15.4 1.0 1 0 0 1 1 1 0 Utp14 protein Menin PF05053.13 KOS21646.1 - 2.7 6.2 17.7 3.4 5.9 17.7 1.3 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 KOS21646.1 - 3.5 7.6 9.7 4.4 7.3 9.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 KOS21646.1 - 3.7 6.5 12.2 4.5 6.2 12.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein SpoIIIAH PF12685.7 KOS21646.1 - 5.1 6.9 17.0 6.2 6.6 17.0 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Lin-8 PF03353.15 KOS21646.1 - 6.5 6.2 15.6 7.8 6.0 15.6 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Sec62 PF03839.16 KOS21646.1 - 6.7 6.2 7.4 8.8 5.8 7.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 HCO3_cotransp PF00955.21 KOS21646.1 - 7.7 5.2 8.2 8.7 5.0 8.2 1.2 1 0 0 1 1 1 0 HCO3- transporter family PNISR PF15996.5 KOS21646.1 - 8 6.7 14.0 9.9 6.4 14.0 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR XRN_M PF17846.1 KOS21646.1 - 9.7 5.0 12.5 12 4.8 12.5 1.0 1 0 0 1 1 1 0 Xrn1 helical domain ALMT PF11744.8 KOS21646.1 - 10 4.8 16.2 12 4.5 16.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SAS4 PF15460.6 KOS21647.1 - 3.9e-30 103.9 0.1 1.5e-29 102.0 0.0 2.1 2 0 0 2 2 2 1 Something about silencing, SAS, complex subunit 4 Macoilin PF09726.9 KOS21647.1 - 0.53 8.8 9.7 0.77 8.2 9.7 1.3 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 KOS21647.1 - 1.2 6.8 12.1 1.6 6.4 12.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Abhydrolase_1 PF00561.20 KOS21648.1 - 4.1e-15 56.1 0.1 6.2e-14 52.3 0.0 2.2 1 1 1 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS21648.1 - 8.1e-13 49.5 1.5 1.1e-12 49.1 1.5 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS21648.1 - 4.9e-10 39.1 0.0 1.2e-08 34.5 0.0 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 KOS21648.1 - 0.00039 20.6 0.0 0.00079 19.6 0.0 1.5 1 0 0 1 1 1 1 Thioesterase domain DUF2048 PF09752.9 KOS21648.1 - 0.0016 17.6 0.0 0.0036 16.4 0.0 1.4 1 1 0 1 1 1 1 Abhydrolase domain containing 18 Esterase PF00756.20 KOS21648.1 - 0.041 13.5 0.0 0.092 12.4 0.0 1.6 1 1 0 1 1 1 0 Putative esterase Abhydrolase_4 PF08386.10 KOS21648.1 - 0.17 12.0 0.0 0.34 11.0 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein Peptidase_S9 PF00326.21 KOS21648.1 - 0.2 11.1 0.0 12 5.3 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family Peptidase_M28 PF04389.17 KOS21649.1 - 9.8e-34 116.8 0.0 1.4e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 Ribophorin_II PF05817.14 KOS21649.1 - 2e-28 99.4 0.0 2.6e-28 99.0 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II CDP-OH_P_transf PF01066.21 KOS21650.1 - 5.1e-16 59.2 0.2 5.1e-16 59.2 0.2 3.4 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Exo70 PF03081.15 KOS21652.1 - 3.5e-44 151.4 0.0 6.4e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Exo70 exocyst complex subunit PfkB PF00294.24 KOS21653.1 - 1.7e-12 47.3 0.1 4.1e-06 26.3 0.4 2.2 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Fungal_trans PF04082.18 KOS21654.1 - 2.7e-28 98.7 0.0 8.2e-28 97.2 0.0 1.9 1 1 0 1 1 1 1 Fungal specific transcription factor domain SPX PF03105.19 KOS21654.1 - 0.19 11.6 15.3 0.014 15.3 1.1 2.3 2 0 0 2 2 2 0 SPX domain GREB1 PF15782.5 KOS21654.1 - 3.1 4.8 7.3 3.8 4.5 0.3 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer DUF1635 PF07795.11 KOS21654.1 - 4.1 7.2 7.8 32 4.3 3.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) WSC PF01822.19 KOS21655.1 - 3.3e-17 62.4 5.6 7.2e-17 61.3 5.6 1.6 1 0 0 1 1 1 1 WSC domain Gpr1_Fun34_YaaH PF01184.19 KOS21656.1 - 1.3e-86 289.5 21.6 1.6e-86 289.2 21.6 1.1 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family S_4TM PF18159.1 KOS21656.1 - 0.54 9.5 1.3 1 8.6 1.3 1.4 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Cyt-b5 PF00173.28 KOS21657.1 - 7e-17 61.3 0.0 1.1e-16 60.8 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain SWIRM-assoc_2 PF16496.5 KOS21657.1 - 3.2 6.5 5.7 4.3 6.1 5.7 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal SpoIIIAH PF12685.7 KOS21658.1 - 7.9 6.2 32.0 0.34 10.7 8.2 2.7 3 0 0 3 3 3 0 SpoIIIAH-like protein MFS_1 PF07690.16 KOS21659.1 - 5e-27 94.7 59.5 7.2e-15 54.7 25.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 KOS21659.1 - 3.3e-08 32.5 19.3 3.3e-08 32.5 19.3 2.8 1 1 2 3 3 3 2 MFS/sugar transport protein OATP PF03137.20 KOS21659.1 - 0.0019 16.5 4.2 0.0057 15.0 4.2 1.8 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family Mito_fiss_reg PF05308.11 KOS21659.1 - 0.051 13.6 3.1 0.076 13.1 3.1 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator RskA PF10099.9 KOS21659.1 - 0.076 13.3 7.1 0.11 12.8 0.6 2.9 3 0 0 3 3 3 0 Anti-sigma-K factor rskA PRIMA1 PF16101.5 KOS21659.1 - 1.1 9.3 12.2 2.9 7.9 12.2 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NIBRIN_BRCT_II PF16508.5 KOS21660.1 - 1.1e-36 125.8 0.0 5.2e-36 123.6 0.0 2.1 2 0 0 2 2 2 1 Second BRCT domain on Nijmegen syndrome breakage protein FHA PF00498.26 KOS21660.1 - 1.8e-07 31.4 0.0 3.4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 FHA domain RTT107_BRCT_5 PF16770.5 KOS21660.1 - 0.019 14.8 0.0 0.019 14.8 0.0 2.8 3 1 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF2670 PF10875.8 KOS21660.1 - 0.18 11.9 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) SQS_PSY PF00494.19 KOS21661.1 - 2.2e-39 135.6 0.0 3e-39 135.1 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase FAS_I_H PF18314.1 KOS21662.1 - 9.4e-76 254.0 0.0 2.7e-75 252.5 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase type I helical domain Fas_alpha_ACP PF18325.1 KOS21662.1 - 2.7e-74 248.9 0.3 8.3e-74 247.3 0.0 1.9 2 0 0 2 2 2 1 Fatty acid synthase subunit alpha Acyl carrier domain ketoacyl-synt PF00109.26 KOS21662.1 - 3.3e-22 79.3 0.0 6.2e-22 78.4 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 KOS21662.1 - 1.8e-19 69.9 0.0 6.5e-19 68.1 0.0 2.1 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 KOS21662.1 - 1.1e-11 44.8 0.0 2.9e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain adh_short PF00106.25 KOS21662.1 - 4.2e-06 26.4 0.0 9.3e-06 25.2 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS21662.1 - 0.00017 21.6 0.0 0.00079 19.4 0.0 2.1 2 0 0 2 2 2 1 KR domain DnaJ-X PF14308.6 KOS21663.1 - 4.7e-77 258.2 3.4 1.2e-76 256.9 0.2 2.5 2 0 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 KOS21663.1 - 3.9e-26 90.9 0.5 8.5e-26 89.9 0.5 1.6 1 0 0 1 1 1 1 DnaJ domain Ndc1_Nup PF09531.10 KOS21663.1 - 2.3 6.8 8.1 3.3 6.3 8.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4378 PF14309.6 KOS21663.1 - 3.4 8.0 6.7 11 6.4 1.1 3.5 3 1 0 3 3 3 0 Domain of unknown function (DUF4378) RmlD_sub_bind PF04321.17 KOS21664.1 - 2.3e-17 63.0 0.0 5.7e-17 61.7 0.0 1.6 1 1 0 1 1 1 1 RmlD substrate binding domain Epimerase PF01370.21 KOS21664.1 - 5e-15 55.6 0.0 8.5e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOS21664.1 - 1.7e-07 30.7 0.0 4.8e-07 29.2 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KOS21664.1 - 4e-06 26.4 0.0 3.3e-05 23.5 0.0 2.0 1 1 1 2 2 2 2 GDP-mannose 4,6 dehydratase KR PF08659.10 KOS21664.1 - 0.049 13.6 0.0 0.18 11.7 0.0 1.8 2 0 0 2 2 2 0 KR domain 3Beta_HSD PF01073.19 KOS21664.1 - 0.11 11.5 0.1 0.24 10.4 0.1 1.6 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF1729 PF08354.10 KOS21665.1 - 1.9e-158 527.0 0.0 3.4e-158 526.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 KOS21665.1 - 1.3e-86 291.0 0.0 8.7e-85 285.0 0.0 3.1 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 KOS21665.1 - 6.3e-55 185.0 0.0 1.3e-54 184.0 0.0 1.6 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 KOS21665.1 - 1e-37 130.2 0.0 2.6e-37 128.8 0.0 1.7 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 KOS21665.1 - 1.9e-36 124.4 0.0 4.2e-36 123.2 0.0 1.6 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 KOS21665.1 - 3.2e-35 121.0 0.0 9.8e-35 119.4 0.0 1.9 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 KOS21665.1 - 2.3e-24 86.0 0.0 8.3e-24 84.2 0.0 2.1 1 0 0 1 1 1 1 N-terminal half of MaoC dehydratase MDM10 PF12519.8 KOS21666.1 - 5 5.9 13.0 8.1 5.2 13.0 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 zinc_ribbon_16 PF17034.5 KOS21667.1 - 0.056 13.7 7.6 0.11 12.7 7.6 1.6 1 0 0 1 1 1 0 Zinc-ribbon like family zf-RING_9 PF13901.6 KOS21667.1 - 0.1 12.6 1.5 0.15 12.0 0.5 1.8 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon Zn_ribbon_17 PF17120.5 KOS21667.1 - 3.4 7.4 22.1 0.63 9.7 13.5 2.7 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type PHD PF00628.29 KOS21667.1 - 3.4 7.6 13.9 1.7 8.6 1.8 3.3 3 1 0 3 3 3 0 PHD-finger DUF4379 PF14311.6 KOS21667.1 - 3.6 8.0 16.8 1.3 9.5 0.2 2.9 2 1 1 3 3 3 0 Probable Zinc-ribbon domain Atg14 PF10186.9 KOS21668.1 - 1.1e-14 54.3 0.1 1.8e-14 53.6 0.1 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 VPS38 PF17649.1 KOS21668.1 - 4.5e-09 35.7 0.0 7.6e-06 25.0 0.0 3.2 3 1 0 3 3 3 2 Vacuolar protein sorting 38 Spc7 PF08317.11 KOS21668.1 - 6.3 5.6 11.3 9.4 5.0 11.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein NUDIX PF00293.28 KOS21669.1 - 6.3e-18 65.1 0.1 7.7e-18 64.8 0.1 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 KOS21669.1 - 0.024 14.6 0.1 0.034 14.1 0.1 1.3 1 1 0 1 1 1 0 NUDIX domain Kdo PF06293.14 KOS21670.1 - 1.1e-05 24.9 0.0 0.00047 19.6 0.0 2.4 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS21670.1 - 1.6e-05 25.0 2.0 0.017 15.1 0.3 2.7 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase PF00069.25 KOS21670.1 - 0.0002 20.8 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain RIO1 PF01163.22 KOS21670.1 - 0.073 12.7 0.0 4.2 6.9 0.0 2.2 2 0 0 2 2 2 0 RIO1 family Pkinase_fungal PF17667.1 KOS21670.1 - 0.11 11.3 0.1 0.15 10.8 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase Aldo_ket_red PF00248.21 KOS21671.1 - 1.6e-07 30.8 0.0 2.1e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Clat_adaptor_s PF01217.20 KOS21672.1 - 3.8e-46 156.5 0.2 4.9e-46 156.2 0.2 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain PulA_N1 PF17999.1 KOS21672.1 - 0.029 15.1 0.1 0.046 14.5 0.1 1.3 1 0 0 1 1 1 0 Pullulanase N1-terminal domain Maf1 PF09174.10 KOS21673.1 - 1.2e-55 188.3 0.0 1.6e-55 187.9 0.0 1.1 1 0 0 1 1 1 1 Maf1 regulator CRAM_rpt PF07016.11 KOS21673.1 - 0.091 12.6 1.4 0.18 11.6 1.4 1.4 1 0 0 1 1 1 0 Cysteine-rich acidic integral membrane protein precursor CsbD PF05532.12 KOS21674.1 - 2.4e-13 49.8 25.2 1.4e-11 44.1 6.3 3.7 3 1 1 4 4 4 3 CsbD-like RRM_1 PF00076.22 KOS21675.1 - 3.9e-13 49.0 0.0 6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 KOS21675.1 - 0.068 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 RNA binding motif Chitin_synth_2 PF03142.15 KOS21677.1 - 1.2e-43 149.6 1.0 2.6e-36 125.3 0.9 2.2 2 0 0 2 2 2 2 Chitin synthase Glycos_transf_2 PF00535.26 KOS21677.1 - 3.9e-09 36.5 0.0 0.00048 20.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 KOS21677.1 - 2.7e-06 27.4 2.3 2.7e-06 27.4 2.3 2.9 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 KOS21677.1 - 0.016 15.1 0.2 0.96 9.3 0.0 2.8 3 0 0 3 3 3 0 Glycosyltransferase like family 2 AvrD PF05655.11 KOS21677.1 - 0.21 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Pseudomonas avirulence D protein (AvrD) YiaAB PF05360.14 KOS21677.1 - 0.25 11.6 4.4 10 6.4 0.0 2.7 2 0 0 2 2 2 0 yiaA/B two helix domain Peptidase_M28 PF04389.17 KOS21678.1 - 2e-27 96.2 0.5 7.7e-13 48.6 0.2 2.3 1 1 1 2 2 2 2 Peptidase family M28 PA PF02225.22 KOS21678.1 - 5e-10 39.3 0.1 1.2e-09 38.1 0.1 1.6 1 0 0 1 1 1 1 PA domain UDPG_MGDP_dh PF00984.19 KOS21679.1 - 1.7e-19 69.8 0.0 4e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 KOS21679.1 - 1.3e-13 50.9 0.1 7.6e-09 35.4 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 KOS21679.1 - 0.0079 16.4 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_C PF03720.15 KOS21679.1 - 0.082 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain TrkA_N PF02254.18 KOS21679.1 - 0.21 11.9 0.0 0.52 10.6 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain Polysacc_deac_1 PF01522.21 KOS21680.1 - 6.4e-27 93.9 0.0 1.1e-26 93.2 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 KOS21680.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Ppx-GppA PF02541.16 KOS21681.1 - 1.2e-35 123.4 0.0 2.8e-35 122.2 0.0 1.6 1 0 0 1 1 1 1 Ppx/GppA phosphatase family Cyclin PF08613.11 KOS21682.1 - 7.1e-44 150.0 0.6 6.1e-43 147.0 0.6 2.0 1 1 0 1 1 1 1 Cyclin SUIM_assoc PF16619.5 KOS21682.1 - 0.012 15.7 3.6 0.024 14.7 3.6 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 VIR_N PF15912.5 KOS21682.1 - 0.035 13.7 3.0 0.026 14.1 1.7 1.3 1 1 0 1 1 1 0 Virilizer, N-terminal Cyclin_N PF00134.23 KOS21682.1 - 0.078 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain Roughex PF06020.11 KOS21682.1 - 0.25 10.4 5.0 0.35 9.9 5.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Pex14_N PF04695.13 KOS21682.1 - 0.65 10.6 6.6 0.21 12.2 3.4 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Fungal_trans PF04082.18 KOS21683.1 - 1.5e-10 40.5 0.1 1.1e-05 24.6 0.0 3.0 2 1 1 3 3 3 3 Fungal specific transcription factor domain MMR_HSR1_C PF08438.10 KOS21685.1 - 6.7e-38 129.7 0.0 1.1e-37 129.0 0.0 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 KOS21685.1 - 9.3e-21 74.0 0.0 2.7e-20 72.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS21685.1 - 4.3e-09 36.1 0.1 2.4e-07 30.4 0.0 2.6 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS21685.1 - 0.0038 17.3 0.5 0.094 12.8 0.3 2.8 3 0 0 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 KOS21685.1 - 0.0089 15.6 0.2 0.49 9.9 0.0 2.9 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 KOS21685.1 - 0.099 12.0 0.2 0.53 9.6 0.1 2.0 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 KOS21685.1 - 0.14 12.0 0.5 12 5.7 0.1 2.3 2 0 0 2 2 2 0 RsgA GTPase TPR_14 PF13428.6 KOS21686.1 - 0.0073 17.0 5.1 0.14 13.0 1.7 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS21686.1 - 1.9 9.2 6.4 6.9 7.4 0.9 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Aminotran_4 PF01063.19 KOS21687.1 - 4.2e-19 69.3 0.0 9e-19 68.2 0.0 1.6 1 1 0 1 1 1 1 Amino-transferase class IV TPR_1 PF00515.28 KOS21688.1 - 7.1e-42 139.6 18.9 2.3e-05 24.0 0.2 11.5 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 KOS21688.1 - 1.6e-40 134.0 19.6 0.00013 21.8 0.1 11.5 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21688.1 - 6.9e-24 82.0 20.0 5.7e-05 23.0 0.1 10.2 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_16 PF13432.6 KOS21688.1 - 7.8e-22 77.6 17.1 2.9e-07 31.0 0.1 6.0 7 0 0 7 7 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 KOS21688.1 - 1.1e-20 72.4 5.5 0.00013 22.1 0.0 8.8 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOS21688.1 - 1.2e-16 60.7 28.4 0.00036 20.8 2.1 8.6 5 2 5 10 10 9 7 Tetratricopeptide repeat TPR_11 PF13414.6 KOS21688.1 - 6.5e-15 54.5 15.4 0.00024 20.7 0.0 8.4 6 1 2 8 8 8 3 TPR repeat TPR_19 PF14559.6 KOS21688.1 - 2.3e-14 53.6 20.9 0.0005 20.5 0.1 7.9 4 2 3 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 KOS21688.1 - 3.7e-14 52.2 15.8 0.0017 19.0 0.2 9.3 4 2 6 10 10 9 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS21688.1 - 2.9e-12 46.6 7.6 9.8e-05 22.4 0.1 6.6 3 2 2 7 7 7 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOS21688.1 - 1.7e-07 30.8 20.2 0.023 14.7 0.2 9.1 9 1 1 10 10 10 2 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS21688.1 - 1e-05 25.6 13.4 0.025 14.8 1.8 5.5 2 2 5 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 KOS21688.1 - 1.4e-05 24.6 5.2 0.0001 21.8 1.8 3.0 2 1 0 2 2 2 1 MalT-like TPR region TPR_6 PF13174.6 KOS21688.1 - 6.9e-05 23.2 19.7 0.21 12.3 0.0 8.5 9 0 0 9 9 8 1 Tetratricopeptide repeat MAS20 PF02064.15 KOS21688.1 - 0.00024 21.2 7.6 0.094 12.8 0.5 4.4 3 1 1 4 4 4 1 MAS20 protein import receptor TPR_10 PF13374.6 KOS21688.1 - 0.0014 18.5 23.3 0.094 12.6 0.7 8.0 7 0 0 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOS21688.1 - 0.0068 15.8 5.5 3 7.4 0.0 4.8 5 0 0 5 5 5 1 SHNi-TPR DUF3856 PF12968.7 KOS21688.1 - 0.017 15.2 7.9 2.4 8.2 0.1 5.0 5 2 0 5 5 4 0 Domain of Unknown Function (DUF3856) Sel1 PF08238.12 KOS21688.1 - 0.21 12.3 0.1 0.21 12.3 0.1 4.8 5 0 0 5 5 4 0 Sel1 repeat TAF1_subA PF14929.6 KOS21688.1 - 0.24 10.8 1.7 1.2 8.5 1.8 2.0 1 1 0 1 1 1 0 TAF RNA Polymerase I subunit A NARP1 PF12569.8 KOS21688.1 - 1.6 7.5 19.7 0.58 9.0 0.1 4.5 2 2 2 4 4 4 0 NMDA receptor-regulated protein 1 HemY_N PF07219.13 KOS21688.1 - 2.4 8.4 12.6 12 6.1 0.0 4.7 4 1 1 5 5 5 0 HemY protein N-terminus MIT PF04212.18 KOS21688.1 - 3.5 7.8 17.9 14 5.8 0.2 6.1 8 0 0 8 8 6 0 MIT (microtubule interacting and transport) domain Syntaxin PF00804.25 KOS21689.1 - 1.2e-23 83.9 3.8 1.2e-23 83.9 3.8 1.5 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 KOS21689.1 - 8e-10 38.6 0.2 1.9e-09 37.3 0.2 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 KOS21689.1 - 0.00095 19.5 2.2 0.00095 19.5 2.2 2.3 2 1 0 2 2 2 1 Syntaxin-like protein DUF3094 PF11293.8 KOS21689.1 - 0.026 14.2 0.1 0.052 13.3 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3094) BatA PF07584.11 KOS21689.1 - 0.053 13.9 0.2 0.15 12.4 0.2 1.7 1 0 0 1 1 1 0 Aerotolerance regulator N-terminal Allexi_40kDa PF05549.11 KOS21689.1 - 0.053 13.0 4.5 0.082 12.4 0.3 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein T6PP_N PF18572.1 KOS21689.1 - 0.11 12.4 1.9 1.5 8.7 0.0 2.9 3 1 1 4 4 4 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain PBP1_TM PF14812.6 KOS21689.1 - 0.32 11.4 2.2 0.35 11.3 0.1 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MCU PF04678.13 KOS21689.1 - 0.57 10.3 4.7 1.4 9.0 4.8 1.8 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Fib_alpha PF08702.10 KOS21689.1 - 3.4 7.9 8.9 6.5 6.9 2.2 2.4 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF3708 PF12501.8 KOS21689.1 - 3.6 7.4 6.4 5.6 6.7 3.1 2.7 1 1 1 2 2 2 0 Phosphate ATP-binding cassette transporter Prominin PF05478.11 KOS21689.1 - 7.2 4.4 7.2 3.9 5.3 0.2 2.3 1 1 1 3 3 3 0 Prominin PP-binding PF00550.25 KOS21690.1 - 3.5e-11 43.3 0.1 5e-11 42.8 0.1 1.3 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 KOS21690.1 - 0.00059 20.0 0.6 0.00082 19.6 0.5 1.4 1 1 0 1 1 1 1 Acyl-carrier zf-CCCH PF00642.24 KOS21691.1 - 1.4e-10 40.8 9.4 1.6e-05 24.7 2.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 KOS21691.1 - 2e-10 40.2 11.8 2.7e-05 23.8 3.5 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOS21691.1 - 4.1e-10 39.4 17.4 7.4e-05 22.7 4.2 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 KOS21691.1 - 4.3e-09 37.0 5.3 0.00016 22.3 0.6 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 KOS21691.1 - 4e-05 23.8 1.1 8.6e-05 22.7 1.1 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOS21691.1 - 0.47 11.0 24.2 0.083 13.4 5.4 2.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger DUF2517 PF10725.9 KOS21692.1 - 0.027 14.3 0.3 0.066 13.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2517) BTB PF00651.31 KOS21693.1 - 0.00013 22.1 0.0 0.00039 20.6 0.0 1.8 1 1 0 1 1 1 1 BTB/POZ domain MFS_1 PF07690.16 KOS21697.1 - 6.8e-35 120.6 40.4 9.8e-22 77.3 15.0 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS21697.1 - 6.5e-07 28.5 13.6 2.5e-06 26.6 10.1 2.4 1 1 1 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 KOS21697.1 - 2.8e-06 26.5 33.7 0.001 18.1 10.6 3.5 2 2 1 3 3 3 3 Sugar (and other) transporter adh_short PF00106.25 KOS21698.1 - 1.2e-31 109.7 0.3 1.6e-31 109.3 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS21698.1 - 4.9e-16 59.0 0.0 6.5e-16 58.6 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS21698.1 - 1.3e-06 28.4 0.2 2e-06 27.8 0.2 1.2 1 0 0 1 1 1 1 KR domain 2OG-FeII_Oxy PF03171.20 KOS21699.1 - 6.8e-07 29.7 0.0 2.2e-06 28.1 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PS-DH PF14765.6 KOS21700.1 - 8.8e-64 215.6 0.6 4.3e-63 213.3 0.0 2.2 2 0 0 2 2 2 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 KOS21700.1 - 1.5e-60 204.9 0.4 3.3e-60 203.8 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Acyl_transf_1 PF00698.21 KOS21700.1 - 2.2e-55 188.4 0.1 4e-55 187.6 0.1 1.4 1 0 0 1 1 1 1 Acyl transferase domain KR PF08659.10 KOS21700.1 - 3.8e-39 134.4 0.0 7.6e-39 133.5 0.0 1.5 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 KOS21700.1 - 4.2e-37 126.8 0.1 1.2e-36 125.3 0.1 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 KOS21700.1 - 7.1e-24 84.4 0.0 1.6e-23 83.3 0.0 1.7 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Glyoxalase_3 PF13468.6 KOS21700.1 - 2.4e-21 76.6 0.0 5.9e-21 75.4 0.0 1.7 1 0 0 1 1 1 1 Glyoxalase-like domain Methyltransf_12 PF08242.12 KOS21700.1 - 6e-16 59.0 0.0 1.7e-15 57.6 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS21700.1 - 3.4e-10 40.0 0.0 7.3e-10 38.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS21700.1 - 4.4e-09 36.9 0.0 1.9e-08 34.9 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS21700.1 - 7.5e-07 29.7 0.0 2.4e-06 28.1 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS21700.1 - 1.3e-06 28.2 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PP-binding PF00550.25 KOS21700.1 - 1.8e-05 25.0 0.0 6e-05 23.3 0.0 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site SAT PF16073.5 KOS21700.1 - 0.026 14.2 0.8 0.093 12.4 0.5 2.0 1 1 0 2 2 2 0 Starter unit:ACP transacylase in aflatoxin biosynthesis Methyltransf_16 PF10294.9 KOS21700.1 - 0.039 13.7 0.0 0.63 9.7 0.0 2.3 2 0 0 2 2 2 0 Lysine methyltransferase CFEM PF05730.11 KOS21701.1 - 1.5e-37 127.5 75.9 5.4e-10 39.2 13.1 4.8 4 0 0 4 4 4 4 CFEM domain FAD_binding_4 PF01565.23 KOS21702.1 - 8.4e-13 48.3 0.2 1.7e-12 47.3 0.2 1.6 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS21702.1 - 6e-09 35.9 0.2 1.2e-08 34.9 0.2 1.5 1 0 0 1 1 1 1 Berberine and berberine like HATPase_c PF02518.26 KOS21703.1 - 6.7e-31 107.1 0.0 1.7e-30 105.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS21703.1 - 1.5e-22 79.8 0.6 3.7e-22 78.6 0.1 2.0 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 KOS21703.1 - 3.4e-18 65.4 0.5 1.4e-17 63.4 0.5 2.2 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain GAF_2 PF13185.6 KOS21703.1 - 1.3e-10 41.7 0.0 2.2e-09 37.8 0.0 2.8 2 0 0 2 2 2 1 GAF domain AAA_16 PF13191.6 KOS21703.1 - 1.7e-10 41.5 0.0 8.9e-10 39.2 0.0 2.3 1 0 0 1 1 1 1 AAA ATPase domain GAF PF01590.26 KOS21703.1 - 2.8e-07 31.2 0.0 1.3e-06 29.0 0.0 2.3 2 0 0 2 2 1 1 GAF domain Pkinase PF00069.25 KOS21703.1 - 3.4e-06 26.6 0.0 8.2e-06 25.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain HATPase_c_3 PF13589.6 KOS21703.1 - 0.00063 19.6 0.0 0.0015 18.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase GAF_3 PF13492.6 KOS21703.1 - 0.059 13.7 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 GAF domain NACHT PF05729.12 KOS21703.1 - 0.16 11.8 0.0 0.52 10.2 0.0 1.9 1 0 0 1 1 1 0 NACHT domain Alanine_zipper PF11839.8 KOS21703.1 - 0.18 12.2 8.1 0.66 10.4 8.1 1.9 1 0 0 1 1 1 0 Alanine-zipper, major outer membrane lipoprotein CDC45 PF02724.14 KOS21703.1 - 0.31 9.3 5.8 0.15 10.4 1.9 1.9 2 0 0 2 2 2 0 CDC45-like protein RXT2_N PF08595.11 KOS21704.1 - 0.0048 16.9 13.6 0.0054 16.8 13.6 1.0 1 0 0 1 1 1 1 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 KOS21704.1 - 0.016 14.9 21.1 0.017 14.9 21.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 KOS21704.1 - 0.059 13.0 8.1 0.078 12.6 8.1 1.2 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 KOS21704.1 - 0.17 9.8 3.0 0.17 9.8 3.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOA36 PF06524.12 KOS21704.1 - 0.24 10.7 22.0 0.29 10.4 22.0 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 KOS21704.1 - 0.42 8.8 14.8 0.4 8.9 14.8 1.0 1 0 0 1 1 1 0 Nop14-like family FYDLN_acid PF09538.10 KOS21704.1 - 0.5 11.1 18.5 0.62 10.8 18.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Pox_Ag35 PF03286.14 KOS21704.1 - 0.54 10.0 7.0 0.57 10.0 7.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TFB6 PF17110.5 KOS21704.1 - 0.61 9.8 9.4 0.73 9.6 9.4 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.14 KOS21704.1 - 2.2 6.5 15.0 2.1 6.5 15.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 KOS21704.1 - 3.5 5.6 7.9 3.4 5.6 7.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PPP4R2 PF09184.11 KOS21704.1 - 5.1 6.6 14.2 5.7 6.5 14.2 1.2 1 0 0 1 1 1 0 PPP4R2 Roughex PF06020.11 KOS21704.1 - 5.2 6.1 8.2 4.9 6.1 8.2 1.0 1 0 0 1 1 1 0 Drosophila roughex protein DUF688 PF05097.12 KOS21704.1 - 5.2 6.1 9.2 6.5 5.8 9.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) SelP_N PF04592.14 KOS21704.1 - 8.6 5.7 23.5 11 5.4 23.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region SDA1 PF05285.12 KOS21704.1 - 9.1 5.6 18.1 9.3 5.6 18.1 1.1 1 0 0 1 1 1 0 SDA1 GCIP PF13324.6 KOS21704.1 - 9.3 5.8 10.2 11 5.6 10.2 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting FMO-like PF00743.19 KOS21705.1 - 2.7e-12 45.9 0.0 3.1e-12 45.7 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOS21705.1 - 1.7e-11 44.0 0.2 2.2e-10 40.3 0.2 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS21705.1 - 1.3e-09 37.7 0.0 4e-09 36.1 0.0 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS21705.1 - 2.1e-09 37.0 0.0 3.6e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOS21705.1 - 1.4e-05 25.2 0.4 0.00015 21.9 0.0 2.9 4 0 0 4 4 4 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOS21705.1 - 0.0027 17.0 0.0 0.014 14.6 0.0 1.9 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 KOS21705.1 - 0.021 14.4 0.3 4.7 6.7 0.2 2.1 1 1 1 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOS21705.1 - 0.075 13.6 0.0 28 5.4 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 KOS21705.1 - 0.11 11.6 0.1 13 4.6 0.0 2.9 2 1 1 3 3 3 0 Lycopene cyclase protein HI0933_like PF03486.14 KOS21705.1 - 0.13 11.0 0.0 6.3 5.4 0.0 2.2 2 0 0 2 2 2 0 HI0933-like protein Peptidase_M43 PF05572.13 KOS21706.1 - 0.12 12.3 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A PLAC8 PF04749.17 KOS21709.1 - 3.5e-10 40.8 1.1 4.8e-10 40.3 1.1 1.2 1 0 0 1 1 1 1 PLAC8 family Glyco_transf_64 PF09258.10 KOS21710.1 - 3.5e-43 147.7 0.0 4.3e-43 147.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 64 domain Glyco_tranf_2_3 PF13641.6 KOS21710.1 - 0.0097 15.8 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 WD40 PF00400.32 KOS21713.1 - 9.1e-10 39.0 9.2 0.01 16.7 0.1 7.9 7 0 0 7 7 7 3 WD domain, G-beta repeat WD40_like PF17005.5 KOS21713.1 - 0.044 13.1 0.8 1.1 8.5 0.2 2.5 3 0 0 3 3 3 0 WD40-like domain Bromodomain PF00439.25 KOS21714.1 - 7e-05 22.8 0.0 0.00023 21.2 0.0 1.8 1 1 0 1 1 1 1 Bromodomain GCN5L1 PF06320.13 KOS21715.1 - 2.9e-13 49.9 0.0 4e-13 49.5 0.0 1.1 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) SOG2 PF10428.9 KOS21716.1 - 1.4e-76 258.7 6.6 4e-55 188.0 1.6 3.7 3 1 1 4 4 4 2 RAM signalling pathway protein LRR_8 PF13855.6 KOS21716.1 - 8.1e-16 57.5 1.8 4.7e-07 29.5 0.4 2.6 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 KOS21716.1 - 3.5e-14 52.7 3.5 1.9e-05 24.9 0.0 3.5 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOS21716.1 - 0.003 17.9 7.9 5.9 7.9 0.4 5.3 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_6 PF13516.6 KOS21716.1 - 0.012 15.6 2.9 17 5.8 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeat DUF2408 PF10303.9 KOS21716.1 - 0.048 14.2 0.1 0.17 12.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) DEAD PF00270.29 KOS21717.1 - 1.3e-07 31.6 0.0 1.6e-07 31.3 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS21718.1 - 1.7e-16 60.6 0.0 4e-16 59.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 KOS21718.1 - 6.6e-13 49.2 2.9 1.7e-12 47.9 2.9 1.7 1 0 0 1 1 1 1 RecQ zinc-binding DUF2470 PF10615.9 KOS21719.1 - 2.1e-06 28.3 0.0 4.2e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2470) DUF4499 PF14934.6 KOS21719.1 - 0.032 14.5 0.6 0.056 13.8 0.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4499) Fungal_trans PF04082.18 KOS21720.1 - 2.1e-13 49.9 1.4 3.5e-13 49.2 1.4 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21720.1 - 6.2e-06 26.2 8.2 1.2e-05 25.3 8.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Methyltransf_24 PF13578.6 KOS21721.1 - 2.4e-10 41.4 0.0 5.1e-10 40.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 KOS21721.1 - 1.8e-09 37.1 0.0 3e-09 36.4 0.0 1.4 1 1 0 1 1 1 1 O-methyltransferase CmcI PF04989.12 KOS21721.1 - 0.084 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase Rgp1 PF08737.10 KOS21722.1 - 9.1e-147 489.6 0.0 1.3e-146 489.1 0.0 1.2 1 0 0 1 1 1 1 Rgp1 Arrestin_C PF02752.22 KOS21722.1 - 0.0016 18.9 0.0 0.043 14.3 0.0 2.5 3 0 0 3 3 3 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 KOS21722.1 - 0.002 18.2 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain GlyL_C PF12524.8 KOS21722.1 - 0.031 14.4 1.3 0.16 12.1 0.1 2.8 2 0 0 2 2 2 0 dsDNA virus glycoprotein L C terminal U1snRNP70_N PF12220.8 KOS21724.1 - 1.7 9.4 8.2 7.2 7.3 1.2 2.7 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal TPP_enzyme_N PF02776.18 KOS21725.1 - 1e-39 135.9 0.0 4.9e-39 133.7 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 KOS21725.1 - 3.3e-22 78.9 0.1 1.5e-21 76.8 0.0 2.1 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOS21725.1 - 2.1e-07 30.8 0.0 7.4e-07 29.0 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain OmpH PF03938.14 KOS21725.1 - 0.24 11.7 2.9 0.41 11.0 2.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Catalase PF00199.19 KOS21726.1 - 2.9e-171 569.8 0.2 3.7e-171 569.5 0.2 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 KOS21726.1 - 4.7e-15 55.5 0.1 1.3e-14 54.2 0.1 1.8 1 0 0 1 1 1 1 Catalase-related immune-responsive Catalase_C PF18011.1 KOS21726.1 - 1.7e-07 31.0 0.0 1.2e-06 28.2 0.0 2.3 1 1 0 1 1 1 1 C-terminal domain found in long catalases DJ-1_PfpI PF01965.24 KOS21726.1 - 2.1e-07 30.9 0.0 3.6e-07 30.1 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family MgtE PF01769.16 KOS21727.1 - 5.6 7.4 7.8 0.62 10.5 2.0 2.3 1 1 1 2 2 2 0 Divalent cation transporter Aldedh PF00171.22 KOS21728.1 - 8e-138 459.8 0.0 9.2e-138 459.6 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family FR47 PF08445.10 KOS21729.1 - 5.4e-05 23.1 0.0 9.5e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_1 PF00583.25 KOS21729.1 - 0.001 19.3 0.0 0.0018 18.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS21729.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Peptidase_S28 PF05577.12 KOS21730.1 - 6.7e-43 147.1 0.0 1.2e-32 113.3 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase S28 Glyco_hydro_18 PF00704.28 KOS21731.1 - 1.6e-24 87.2 0.4 3.5e-24 86.1 0.4 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 CSD PF00313.22 KOS21733.1 - 2.3e-28 97.8 1.0 2.5e-28 97.7 1.0 1.0 1 0 0 1 1 1 1 'Cold-shock' DNA-binding domain OB_RNB PF08206.11 KOS21733.1 - 0.01 15.5 0.2 0.019 14.6 0.2 1.5 1 0 0 1 1 1 0 Ribonuclease B OB domain CusF_Ec PF11604.8 KOS21733.1 - 0.014 15.4 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 Copper binding periplasmic protein CusF Glyco_hyd_65N_2 PF14498.6 KOS21735.1 - 1.6e-44 152.6 0.0 2.2e-44 152.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain APG17 PF04108.12 KOS21737.1 - 6.5e-119 397.6 3.5 7.5e-119 397.4 3.5 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 FAM104 PF15434.6 KOS21737.1 - 0.033 14.7 0.1 0.11 13.0 0.1 1.8 1 0 0 1 1 1 0 Family 104 Bacillus_HBL PF05791.11 KOS21737.1 - 0.075 12.8 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) Cyt-b5 PF00173.28 KOS21738.1 - 2.8e-13 49.8 0.0 3.7e-13 49.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TFR_dimer PF04253.15 KOS21739.1 - 2.2e-32 111.7 0.0 4.6e-32 110.7 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 KOS21739.1 - 3.9e-22 78.9 0.0 6.7e-21 74.9 0.0 2.4 3 0 0 3 3 3 1 Peptidase family M28 PA PF02225.22 KOS21739.1 - 5.8e-12 45.5 0.0 1.2e-11 44.5 0.0 1.5 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 KOS21739.1 - 0.015 15.0 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Peptidase family M20/M25/M40 DUF3899 PF13038.6 KOS21739.1 - 0.019 15.4 0.2 0.045 14.3 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Vps35 PF03635.17 KOS21740.1 - 3.9e-293 974.5 0.5 4.6e-293 974.3 0.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 WHIM1 PF15612.6 KOS21740.1 - 0.031 13.8 0.1 0.076 12.6 0.1 1.7 1 0 0 1 1 1 0 WSTF, HB1, Itc1p, MBD9 motif 1 Tim44 PF04280.15 KOS21741.1 - 3.8e-36 124.4 0.2 5.3e-35 120.7 0.0 2.3 2 0 0 2 2 2 1 Tim44-like domain Caprin-1_dimer PF18293.1 KOS21741.1 - 0.067 13.7 0.1 0.22 12.0 0.0 1.9 1 1 0 1 1 1 0 Caprin-1 dimerization domain Med7 PF05983.11 KOS21741.1 - 0.4 10.7 5.0 0.82 9.7 5.0 1.5 1 0 0 1 1 1 0 MED7 protein Ribosomal_S11 PF00411.19 KOS21742.1 - 6.5e-06 26.5 0.0 1e-05 25.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S11 Peptidase_C97 PF05903.14 KOS21743.1 - 2e-34 118.6 0.0 2.6e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRAT PF04970.13 KOS21743.1 - 0.0042 17.4 0.0 0.0069 16.7 0.0 1.3 1 0 0 1 1 1 1 Lecithin retinol acyltransferase YchF-GTPase_C PF06071.13 KOS21744.1 - 8.1e-34 115.7 0.2 2.3e-33 114.2 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 KOS21744.1 - 1.3e-15 57.4 0.0 3e-15 56.3 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 KOS21744.1 - 0.0012 18.4 0.0 0.0023 17.5 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 KOS21744.1 - 0.0031 17.5 0.1 0.0072 16.4 0.1 1.6 1 0 0 1 1 1 1 TGS domain AKAP95 PF04988.12 KOS21744.1 - 0.15 12.3 0.2 0.26 11.5 0.2 1.3 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) AAA_23 PF13476.6 KOS21744.1 - 0.3 11.6 5.5 9.8 6.6 5.4 2.2 1 1 0 1 1 1 0 AAA domain VPS9 PF02204.18 KOS21746.1 - 1.9e-20 73.0 0.1 4.9e-20 71.7 0.1 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 KOS21746.1 - 7.3e-18 64.4 0.2 4.6e-14 52.3 0.0 4.5 4 1 1 5 5 5 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS21746.1 - 2.6e-13 50.3 0.2 7.6e-05 23.2 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS21746.1 - 2e-09 37.8 0.6 0.0021 18.6 0.0 5.1 3 2 2 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS21746.1 - 1.8e-07 30.9 0.3 0.12 13.0 0.0 5.6 5 0 0 5 5 5 1 Ankyrin repeat PX PF00787.24 KOS21746.1 - 0.00039 20.4 0.0 0.0011 18.9 0.0 1.8 1 0 0 1 1 1 1 PX domain Ank PF00023.30 KOS21746.1 - 0.0012 19.2 5.2 10 6.8 0.0 6.0 6 0 0 6 6 6 1 Ankyrin repeat DARPP-32 PF05395.12 KOS21746.1 - 0.032 14.4 0.2 0.074 13.3 0.2 1.5 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 DUF2263 PF10021.9 KOS21747.1 - 3.1e-22 79.5 0.0 6.9e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) PAP2 PF01569.21 KOS21748.1 - 3e-26 91.8 0.6 3e-26 91.8 0.6 1.6 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 KOS21748.1 - 0.0018 18.0 6.6 0.058 13.1 6.6 2.4 1 1 0 1 1 1 1 PAP2 superfamily VanZ PF04892.12 KOS21748.1 - 0.26 12.0 3.9 1 10.1 1.9 2.2 2 1 0 2 2 2 0 VanZ like family MerC PF03203.14 KOS21748.1 - 1.1 9.7 6.2 9.8 6.7 0.1 3.0 1 1 1 2 2 2 0 MerC mercury resistance protein WW PF00397.26 KOS21749.1 - 1.1e-09 38.2 2.1 2.5e-09 37.1 2.1 1.7 1 0 0 1 1 1 1 WW domain FF PF01846.19 KOS21749.1 - 1.6e-08 34.6 3.8 4.4e-07 30.0 0.1 2.8 2 0 0 2 2 2 2 FF domain SPOC PF07744.13 KOS21750.1 - 5.7e-23 81.5 0.0 9.5e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 SPOC domain TFIIS_M PF07500.14 KOS21750.1 - 8.3e-17 61.7 0.2 2.4e-16 60.2 0.2 1.8 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain PHD PF00628.29 KOS21750.1 - 5.5e-08 32.6 9.2 1e-07 31.7 9.2 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOS21750.1 - 1.3 8.6 6.5 2.4 7.8 6.5 1.4 1 0 0 1 1 1 0 PHD-finger Proteasome PF00227.26 KOS21751.1 - 2.1e-60 203.5 0.1 2.5e-60 203.2 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOS21751.1 - 8.3e-14 51.0 0.1 8.7e-13 47.7 0.1 2.3 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature DUF5624 PF18538.1 KOS21751.1 - 0.015 15.4 0.4 0.031 14.4 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5624) Nitrate_red_gam PF02665.14 KOS21751.1 - 0.021 14.3 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Nitrate reductase gamma subunit AMP-binding PF00501.28 KOS21753.1 - 2.5e-45 154.8 0.0 3e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme NOZZLE PF08744.10 KOS21753.1 - 0.17 11.3 0.0 0.24 10.9 0.0 1.1 1 0 0 1 1 1 0 Plant transcription factor NOZZLE IF-2B PF01008.17 KOS21754.1 - 4e-14 52.5 0.0 5.2e-14 52.1 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family NUDIX PF00293.28 KOS21754.1 - 1.3e-11 44.7 0.0 2.5e-11 43.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain K_oxygenase PF13434.6 KOS21755.1 - 1.2e-85 287.7 0.0 1.9e-85 287.1 0.0 1.3 1 1 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 KOS21755.1 - 0.00016 21.0 0.0 0.0014 18.0 0.0 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS21755.1 - 0.0019 17.5 0.0 0.035 13.3 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS21755.1 - 0.011 15.7 0.0 0.086 12.8 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding DUF2760 PF10816.8 KOS21755.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2760) AMP-binding PF00501.28 KOS21756.1 - 5.4e-48 163.6 0.0 6.4e-48 163.4 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 KOS21757.1 - 9.2e-11 41.1 0.0 1.1e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Condensation domain Ribosomal_60s PF00428.19 KOS21757.1 - 0.026 15.1 0.6 0.09 13.4 0.6 1.9 1 0 0 1 1 1 0 60s Acidic ribosomal protein RIO1 PF01163.22 KOS21758.1 - 9.9e-68 227.4 0.1 3.9e-67 225.5 0.0 1.9 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 KOS21758.1 - 0.0071 16.3 0.1 6.2 6.7 0.0 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 KOS21758.1 - 0.045 13.1 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family rRNA_processing PF08524.11 KOS21758.1 - 1.6 8.7 17.2 1.8 8.6 10.4 2.5 2 1 0 2 2 2 0 rRNA processing PI3K_1B_p101 PF10486.9 KOS21758.1 - 9.4 3.9 9.5 6.4 4.4 1.6 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ceramidase PF05875.12 KOS21759.1 - 1.5e-78 263.8 7.5 1.8e-78 263.6 7.5 1.0 1 0 0 1 1 1 1 Ceramidase Leader_Trp PF08255.11 KOS21759.1 - 0.026 14.4 1.3 0.082 12.9 1.3 1.8 1 0 0 1 1 1 0 Trp-operon Leader Peptide DoxX_2 PF13564.6 KOS21759.1 - 2.7 8.1 10.9 1.5 9.0 2.5 3.1 2 1 1 3 3 3 0 DoxX-like family DUF4212 PF13937.6 KOS21759.1 - 5.1 7.6 10.6 0.3 11.5 3.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4212) Hydrolase_4 PF12146.8 KOS21761.1 - 2.3e-07 30.3 0.2 4.4e-07 29.4 0.2 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 KOS21761.1 - 0.0056 16.4 0.0 0.0099 15.5 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 KOS21761.1 - 0.029 14.1 0.1 0.28 10.9 0.0 2.2 2 0 0 2 2 2 0 Alpha/beta hydrolase family Bestrophin PF01062.21 KOS21762.1 - 1.4e-36 126.5 0.0 2.6e-36 125.5 0.0 1.3 1 1 0 1 1 1 1 Bestrophin, RFP-TM, chloride channel Arginosuc_synth PF00764.19 KOS21763.1 - 5.3e-114 381.5 0.0 8.1e-60 203.1 0.0 2.3 1 1 1 2 2 2 2 Arginosuccinate synthase QueC PF06508.13 KOS21763.1 - 0.002 17.7 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 KOS21763.1 - 0.07 11.9 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Mur_ligase PF01225.25 KOS21763.1 - 0.16 12.4 0.1 1.9 8.9 0.0 2.5 3 0 0 3 3 3 0 Mur ligase family, catalytic domain MFS_1 PF07690.16 KOS21764.1 - 3.5e-30 105.1 38.7 5.2e-30 104.6 38.7 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily GPR_Gpa2_C PF11970.8 KOS21764.1 - 2.8 8.1 6.7 1.4 9.0 0.3 3.4 3 0 0 3 3 3 0 G protein-coupled glucose receptor regulating Gpa2 C-term PRMT5_TIM PF17285.2 KOS21765.1 - 6.4e-70 235.3 0.0 8.8e-70 234.8 0.0 1.1 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 KOS21765.1 - 5.3e-67 225.0 0.0 9.2e-67 224.2 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 KOS21765.1 - 6.5e-58 195.5 0.0 9.6e-58 194.9 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain Met_10 PF02475.16 KOS21765.1 - 0.054 13.2 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Met-10+ like-protein OB_NTP_bind PF07717.16 KOS21766.1 - 4.5e-22 78.2 0.0 2.5e-21 75.8 0.0 2.3 3 0 0 3 3 3 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KOS21766.1 - 3.1e-18 66.0 0.0 9e-18 64.5 0.0 1.8 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOS21766.1 - 5.7e-11 42.7 0.0 3.4e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS21766.1 - 1.1e-08 35.1 0.1 2.2e-08 34.0 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOS21766.1 - 7.2e-06 26.3 0.0 2.2e-05 24.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 KOS21766.1 - 0.0005 19.8 0.2 0.0016 18.1 0.2 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_30 PF13604.6 KOS21766.1 - 0.0011 18.7 0.0 0.0021 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS21766.1 - 0.0036 17.7 0.1 0.0076 16.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOS21766.1 - 0.019 14.1 0.0 0.045 12.8 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein ResIII PF04851.15 KOS21766.1 - 0.02 14.9 0.1 2.2 8.3 0.1 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 KOS21766.1 - 0.033 13.4 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 KOS21766.1 - 0.033 14.4 0.1 0.2 11.8 0.1 2.4 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 KOS21766.1 - 0.057 13.4 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain AAA_23 PF13476.6 KOS21766.1 - 0.15 12.5 0.0 0.36 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain CRM1_C PF08767.11 KOS21767.1 - 7.2e-131 436.1 1.7 7.2e-131 436.1 1.7 2.8 3 0 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 KOS21767.1 - 6.9e-41 139.8 16.8 7.4e-41 139.7 7.6 4.0 4 0 0 4 4 4 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 KOS21767.1 - 9.4e-34 114.9 3.9 3.7e-33 113.0 3.9 2.2 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 KOS21767.1 - 6.3e-28 96.6 5.1 9.8e-28 96.0 1.2 3.4 3 0 0 3 3 3 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 KOS21767.1 - 2.7e-19 68.4 2.0 7.3e-19 67.0 2.0 1.8 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 KOS21767.1 - 3.2e-10 39.8 1.0 7.2e-10 38.6 0.1 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 KOS21767.1 - 0.0068 16.3 12.5 0.35 10.8 0.0 4.4 6 0 0 6 6 6 2 Domain of unknown function (DUF3385) Hemocyanin_M PF00372.19 KOS21767.1 - 0.043 13.0 0.1 0.16 11.1 0.1 1.9 1 1 0 1 1 1 0 Hemocyanin, copper containing domain MMS19_C PF12460.8 KOS21767.1 - 0.36 9.9 10.2 0.027 13.6 0.4 3.4 3 3 0 3 3 3 0 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 KOS21767.1 - 0.42 11.2 6.3 6.8 7.4 0.0 5.2 7 0 0 7 7 7 0 Vacuolar 14 Fab1-binding region Aminotran_5 PF00266.19 KOS21768.1 - 3.1e-28 98.8 0.0 3.8e-28 98.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DEAD PF00270.29 KOS21769.1 - 2.2e-35 122.0 0.0 5.2e-35 120.8 0.0 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS21769.1 - 3.6e-21 75.6 0.0 8.2e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 KOS21769.1 - 5.7e-20 71.3 0.0 1e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 KOS21769.1 - 0.0077 16.3 0.0 0.028 14.4 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 KOS21769.1 - 0.081 13.2 0.0 0.42 10.9 0.0 2.1 1 1 0 1 1 1 0 AAA domain PPL5 PF18168.1 KOS21769.1 - 5.5 6.2 8.2 8.2 5.6 8.2 1.2 1 0 0 1 1 1 0 Prim-pol family 5 KxDL PF10241.9 KOS21771.1 - 3.1e-33 113.9 1.1 4.5e-33 113.4 1.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein XylR_N PF06505.11 KOS21771.1 - 0.024 14.4 0.2 0.033 13.9 0.2 1.2 1 0 0 1 1 1 0 Activator of aromatic catabolism OmpH PF03938.14 KOS21771.1 - 0.24 11.7 3.3 0.37 11.1 3.3 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2244 PF10003.9 KOS21772.1 - 0.26 11.0 1.4 0.94 9.1 1.4 1.9 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) SRTM1 PF15872.5 KOS21774.1 - 0.011 15.9 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 FAM75 PF14650.6 KOS21774.1 - 0.94 9.0 12.8 1.2 8.6 12.8 1.1 1 0 0 1 1 1 0 FAM75 family NOA36 PF06524.12 KOS21774.1 - 6.3 6.0 6.1 8 5.7 6.1 1.1 1 0 0 1 1 1 0 NOA36 protein Spt20 PF12090.8 KOS21774.1 - 8.8 5.9 9.6 11 5.5 9.6 1.2 1 0 0 1 1 1 0 Spt20 family IBR PF01485.21 KOS21775.1 - 2.2e-10 40.6 33.3 1.6e-05 25.1 2.0 4.0 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 KOS21775.1 - 0.00052 20.3 6.1 0.00052 20.3 6.1 3.5 3 0 0 3 3 3 1 Ring finger domain zf-RING_5 PF14634.6 KOS21775.1 - 0.0037 17.2 4.7 0.0037 17.2 4.7 3.6 3 0 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 KOS21775.1 - 0.0039 17.0 3.5 0.0039 17.0 3.5 4.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 KOS21775.1 - 0.0078 15.9 3.9 0.0078 15.9 3.9 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 KOS21775.1 - 0.27 11.3 10.9 0.067 13.2 6.6 2.4 2 0 0 2 2 2 0 RING-type zinc-finger ADH_N PF08240.12 KOS21776.1 - 0.0034 17.2 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain DUF4336 PF14234.6 KOS21777.1 - 1.7e-12 47.2 0.2 3.7e-07 29.6 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4336) MMR_HSR1 PF01926.23 KOS21779.1 - 2.8e-10 40.3 0.1 4.5e-10 39.6 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS21779.1 - 0.00025 21.0 0.1 0.0004 20.3 0.1 1.4 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 KOS21779.1 - 0.0013 18.2 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 KOS21779.1 - 0.0066 17.0 0.1 0.011 16.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 KOS21779.1 - 0.0088 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Arf PF00025.21 KOS21779.1 - 0.025 14.0 0.1 0.058 12.8 0.0 1.6 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.6 KOS21779.1 - 0.031 14.7 0.1 0.041 14.3 0.1 1.3 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 KOS21779.1 - 0.06 12.7 0.0 0.086 12.2 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family MCM PF00493.23 KOS21779.1 - 0.07 12.2 0.1 0.091 11.8 0.1 1.1 1 0 0 1 1 1 0 MCM P-loop domain Septin PF00735.18 KOS21779.1 - 0.074 12.3 0.0 0.094 12.0 0.0 1.1 1 0 0 1 1 1 0 Septin AAA_28 PF13521.6 KOS21779.1 - 0.095 12.9 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain IIGP PF05049.13 KOS21779.1 - 0.11 11.6 0.0 0.14 11.2 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) NB-ARC PF00931.22 KOS21779.1 - 0.12 11.5 0.1 0.21 10.7 0.1 1.4 1 1 0 1 1 1 0 NB-ARC domain Dynamin_N PF00350.23 KOS21779.1 - 0.13 12.4 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Dynamin family Roc PF08477.13 KOS21779.1 - 0.13 12.5 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 KOS21779.1 - 0.18 12.3 0.1 0.27 11.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_M24 PF00557.24 KOS21780.1 - 2.3e-59 200.6 0.1 3e-59 200.2 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOS21780.1 - 2.1e-20 72.7 0.0 4.8e-20 71.5 0.0 1.6 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NFACT-R_1 PF05670.13 KOS21781.1 - 6.5e-37 126.5 0.6 2.1e-35 121.7 0.6 2.3 1 1 0 1 1 1 1 NFACT protein RNA binding domain Mrx7 PF10906.8 KOS21781.1 - 0.66 10.3 5.0 1.7 9.0 5.0 1.8 1 1 0 1 1 1 0 MIOREX complex component 7 DUF4337 PF14235.6 KOS21781.1 - 2.8 8.0 7.7 4.4 7.4 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HeLo PF14479.6 KOS21783.1 - 1.3e-07 31.6 0.4 0.012 15.5 0.0 2.3 1 1 1 2 2 2 2 Prion-inhibition and propagation Cnl2_NKP2 PF09447.10 KOS21783.1 - 0.0053 16.9 0.7 0.034 14.3 0.4 2.5 2 1 0 2 2 2 1 Cnl2/NKP2 family protein Rotamase PF00639.21 KOS21783.1 - 0.029 15.3 0.0 1.5 9.9 0.0 2.4 2 1 0 2 2 2 0 PPIC-type PPIASE domain NUDE_C PF04880.13 KOS21784.1 - 2.4e-39 135.7 9.1 2.4e-39 135.7 9.1 2.7 2 1 0 2 2 2 1 NUDE protein, C-terminal conserved region ZapB PF06005.12 KOS21784.1 - 0.00075 19.9 11.5 0.00075 19.9 11.5 4.4 2 1 2 4 4 4 2 Cell division protein ZapB Uso1_p115_C PF04871.13 KOS21784.1 - 0.068 13.6 33.1 0.24 11.8 15.3 3.1 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fez1 PF06818.15 KOS21784.1 - 0.11 13.0 31.8 0.33 11.4 17.9 2.7 2 1 1 3 3 3 0 Fez1 Fmp27_WPPW PF10359.9 KOS21784.1 - 0.22 10.3 21.4 0.054 12.3 10.7 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain YabA PF06156.13 KOS21784.1 - 0.33 11.6 19.3 0.16 12.6 7.2 2.6 2 0 0 2 2 2 0 Initiation control protein YabA PSII_Pbs27 PF13326.6 KOS21784.1 - 0.58 10.5 8.7 0.035 14.4 3.3 1.7 2 0 0 2 2 2 0 Photosystem II Pbs27 Chibby PF14645.6 KOS21784.1 - 0.69 10.3 13.4 0.86 10.0 3.1 2.5 1 1 1 2 2 2 0 Chibby family AAA_13 PF13166.6 KOS21784.1 - 0.82 8.2 18.3 8.3 4.9 20.1 1.7 2 0 0 2 2 2 0 AAA domain CENP-F_leu_zip PF10473.9 KOS21784.1 - 1.4 8.9 37.6 7.1 6.7 16.7 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 KOS21784.1 - 1.9 7.3 26.6 3.1 6.6 26.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) ERM PF00769.19 KOS21784.1 - 2.5 7.9 43.5 0.012 15.4 22.1 2.3 2 1 1 3 3 3 0 Ezrin/radixin/moesin family GrpE PF01025.19 KOS21784.1 - 3.3 7.4 28.5 0.39 10.4 4.4 3.2 1 1 1 2 2 2 0 GrpE Seryl_tRNA_N PF02403.22 KOS21784.1 - 5.6 7.2 22.8 4 7.7 7.3 2.8 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ACC_central PF08326.12 KOS21785.1 - 1.5e-281 935.9 0.0 1.9e-281 935.6 0.0 1.1 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 KOS21785.1 - 7.8e-185 615.2 0.0 1.1e-184 614.7 0.0 1.2 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 KOS21785.1 - 1.8e-52 177.9 0.0 4.3e-52 176.7 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 KOS21785.1 - 7.7e-28 97.2 0.3 2.6e-27 95.5 0.1 2.1 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 KOS21785.1 - 1.1e-21 76.9 0.0 1e-18 67.4 0.0 3.6 3 0 0 3 3 3 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 KOS21785.1 - 2.1e-17 62.7 0.2 5.8e-17 61.3 0.2 1.8 1 0 0 1 1 1 1 Biotin-requiring enzyme GxGYxYP_N PF16216.5 KOS21785.1 - 0.00034 20.9 0.1 0.014 15.6 0.0 2.5 2 0 0 2 2 2 1 GxGYxY sequence motif in domain of unknown function N-terminal Biotin_lipoyl_2 PF13533.6 KOS21785.1 - 0.0018 18.0 0.1 0.0083 15.9 0.0 2.1 2 0 0 2 2 2 1 Biotin-lipoyl like ATP-grasp_3 PF02655.14 KOS21785.1 - 0.0049 16.9 0.0 0.016 15.2 0.0 1.9 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 KOS21785.1 - 0.0053 16.3 0.0 0.021 14.4 0.0 2.0 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_Ter PF15632.6 KOS21785.1 - 0.077 12.7 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon BolA PF01722.18 KOS21786.1 - 2.8e-10 40.3 0.0 6.1e-10 39.2 0.0 1.5 1 1 0 1 1 1 1 BolA-like protein Flavokinase PF01687.17 KOS21787.1 - 4e-10 40.0 0.0 7.9e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Riboflavin kinase fn3_5 PF06280.12 KOS21788.1 - 0.011 16.4 0.0 0.028 15.1 0.0 1.8 1 1 0 1 1 1 0 Fn3-like domain DUF5545 PF17699.1 KOS21788.1 - 0.027 14.3 0.6 0.027 14.3 0.6 1.4 2 0 0 2 2 2 0 Family of unknown function (DUF5545) NST1 PF13945.6 KOS21790.1 - 1.2e-48 165.8 14.3 1.2e-48 165.8 14.3 4.9 3 2 1 4 4 4 1 Salt tolerance down-regulator HET PF06985.11 KOS21793.1 - 0.0026 18.1 0.0 0.0058 17.0 0.0 1.5 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) DUF3446 PF11928.8 KOS21793.1 - 0.068 13.5 2.3 1.2 9.4 1.0 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain Cutinase PF01083.22 KOS21794.1 - 2.2e-45 154.8 1.0 2.8e-45 154.5 1.0 1.1 1 0 0 1 1 1 1 Cutinase Pox_P4B PF03292.14 KOS21794.1 - 0.27 9.5 0.2 0.34 9.1 0.2 1.1 1 0 0 1 1 1 0 Poxvirus P4B major core protein MFS_1 PF07690.16 KOS21795.1 - 1.4e-21 76.8 36.7 7.9e-21 74.4 36.7 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS21795.1 - 2.2e-06 26.4 12.4 2.9e-06 26.0 12.4 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1418 PF07214.12 KOS21795.1 - 1.9 8.4 4.2 1.1 9.2 0.1 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF1418) Inhibitor_I78 PF11720.8 KOS21797.1 - 6.3e-06 26.2 0.0 9.1e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase inhibitor I78 family potato_inhibit PF00280.18 KOS21797.1 - 0.025 15.2 0.0 0.033 14.9 0.0 1.2 1 0 0 1 1 1 0 Potato inhibitor I family Pre-PUA PF17832.1 KOS21798.1 - 7.1e-19 68.3 0.2 9.8e-19 67.8 0.2 1.2 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 KOS21798.1 - 3.9e-12 46.0 0.1 8.3e-06 25.7 0.0 2.1 2 0 0 2 2 2 2 PUA domain DUF1947 PF09183.10 KOS21798.1 - 0.16 12.3 0.0 0.29 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Tcf25 PF04910.14 KOS21800.1 - 2.2e-59 201.3 0.0 2.9e-59 200.9 0.0 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 BUD22 PF09073.10 KOS21800.1 - 0.021 14.2 17.6 0.038 13.3 17.6 1.5 1 0 0 1 1 1 0 BUD22 YL1 PF05764.13 KOS21800.1 - 0.082 13.0 17.1 0.16 12.0 17.1 1.6 1 0 0 1 1 1 0 YL1 nuclear protein Shadoo PF14999.6 KOS21800.1 - 1.5 9.0 9.3 0.71 10.0 6.4 2.0 2 0 0 2 2 2 0 Shadow of prion protein, neuroprotective CDC45 PF02724.14 KOS21800.1 - 6.1 5.0 19.5 7.1 4.8 18.3 1.6 2 0 0 2 2 2 0 CDC45-like protein LSM14 PF12701.7 KOS21801.1 - 8.5e-25 86.7 0.0 1.1e-24 86.3 0.0 1.1 1 0 0 1 1 1 1 Scd6-like Sm domain SM-ATX PF14438.6 KOS21801.1 - 0.00043 20.4 0.0 0.00056 20.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain V-SNARE PF05008.15 KOS21802.1 - 1.9e-20 73.0 2.2 1.9e-20 73.0 2.2 1.6 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 KOS21802.1 - 5.1e-16 58.7 1.8 5.1e-16 58.7 1.8 2.7 3 1 0 3 3 3 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KOS21802.1 - 0.00073 19.4 0.3 0.0022 17.9 0.3 1.8 1 0 0 1 1 1 1 Sec20 FAM219A PF15260.6 KOS21802.1 - 0.0086 16.4 0.5 0.019 15.3 0.5 1.6 1 0 0 1 1 1 1 Protein family FAM219A Fusion_gly PF00523.18 KOS21802.1 - 0.046 12.0 1.2 0.078 11.2 0.4 1.7 2 0 0 2 2 2 0 Fusion glycoprotein F0 DUF1513 PF07433.11 KOS21802.1 - 0.068 12.3 0.0 0.089 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) FAM76 PF16046.5 KOS21802.1 - 0.098 12.0 0.1 0.15 11.4 0.1 1.2 1 0 0 1 1 1 0 FAM76 protein Use1 PF09753.9 KOS21802.1 - 0.18 11.5 4.7 2.3 7.9 4.7 2.4 1 1 0 1 1 1 0 Membrane fusion protein Use1 SNARE PF05739.19 KOS21802.1 - 1.4 9.0 5.0 0.54 10.3 0.4 2.4 3 0 0 3 3 3 0 SNARE domain Amino_oxidase PF01593.24 KOS21803.1 - 1.9e-21 76.9 0.1 4.8e-16 59.1 0.0 2.8 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS21803.1 - 5.6e-10 39.3 0.1 1.5e-09 37.9 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS21803.1 - 0.00042 19.6 0.0 0.013 14.7 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS21803.1 - 0.0028 17.3 0.0 0.011 15.3 0.0 2.0 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.6 KOS21803.1 - 0.0042 17.1 0.1 0.75 9.8 0.0 2.7 2 1 1 3 3 3 1 FAD-NAD(P)-binding HI0933_like PF03486.14 KOS21803.1 - 0.0046 15.7 0.0 0.91 8.2 0.0 2.1 2 0 0 2 2 2 2 HI0933-like protein FAD_oxidored PF12831.7 KOS21803.1 - 0.06 12.7 0.0 0.081 12.3 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOS21803.1 - 0.19 12.3 0.0 0.84 10.2 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase CtaG_Cox11 PF04442.14 KOS21804.1 - 2.5e-59 199.6 0.0 3.5e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 SR-25 PF10500.9 KOS21804.1 - 0.31 10.6 5.3 0.4 10.2 5.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_C58 PF03543.14 KOS21805.1 - 0.077 12.7 0.0 0.077 12.7 0.0 1.9 2 0 0 2 2 2 0 Yersinia/Haemophilus virulence surface antigen Prefoldin_2 PF01920.20 KOS21806.1 - 6.8e-23 80.6 2.3 8.7e-23 80.3 2.3 1.1 1 0 0 1 1 1 1 Prefoldin subunit GrpE PF01025.19 KOS21807.1 - 0.0012 18.5 5.7 0.0012 18.5 5.7 2.1 2 0 0 2 2 2 1 GrpE FlxA PF14282.6 KOS21807.1 - 0.018 15.0 21.0 2.3 8.2 14.2 3.7 2 1 0 2 2 2 0 FlxA-like protein Metal_hydrol PF10118.9 KOS21807.1 - 0.058 13.1 1.4 0.1 12.3 1.4 1.3 1 0 0 1 1 1 0 Predicted metal-dependent hydrolase GRP PF07172.11 KOS21807.1 - 0.17 12.6 11.5 0.56 10.9 11.5 1.8 1 0 0 1 1 1 0 Glycine rich protein family HSP70 PF00012.20 KOS21808.1 - 4.2e-58 197.0 16.5 7.3e-57 192.9 0.2 2.9 3 0 0 3 3 3 2 Hsp70 protein MreB_Mbl PF06723.13 KOS21808.1 - 0.00058 18.8 0.1 0.0013 17.6 0.1 1.7 1 0 0 1 1 1 1 MreB/Mbl protein TrmK PF04816.12 KOS21808.1 - 0.076 12.6 0.4 5.2 6.6 0.3 2.3 2 0 0 2 2 2 0 tRNA (adenine(22)-N(1))-methyltransferase Mod_r PF07200.13 KOS21808.1 - 1.2 9.2 15.5 4.2 7.5 0.3 2.8 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein SlyX PF04102.12 KOS21808.1 - 1.8 9.2 4.1 3.1 8.5 0.4 3.3 3 0 0 3 3 3 0 SlyX DUF3484 PF11983.8 KOS21808.1 - 2.2 9.5 0.0 2.2 9.5 0.0 3.6 3 0 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch Profilin PF00235.19 KOS21809.1 - 9.4e-22 77.6 0.0 1.1e-21 77.4 0.0 1.1 1 0 0 1 1 1 1 Profilin GAT PF03127.14 KOS21810.1 - 3.2e-17 62.6 0.0 5.7e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 GAT domain VHS PF00790.19 KOS21810.1 - 0.0057 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 VHS domain DUF3110 PF11360.8 KOS21810.1 - 0.18 12.0 0.1 4.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3110) ADH_N PF08240.12 KOS21811.1 - 1.9e-28 98.5 0.2 3.8e-28 97.6 0.2 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 KOS21811.1 - 2.3e-16 60.0 0.5 4.6e-16 59.0 0.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 KOS21811.1 - 5.7e-12 45.6 0.3 2.9e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 Glucose dehydrogenase C-terminus FAD_binding_2 PF00890.24 KOS21811.1 - 0.0072 15.5 2.7 0.011 14.9 2.7 1.3 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 KOS21811.1 - 0.1 11.9 3.7 0.039 13.3 1.2 1.6 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain DUF2064 PF09837.9 KOS21811.1 - 0.12 12.1 0.3 2 8.3 0.1 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) UDPG_MGDP_dh_N PF03721.14 KOS21811.1 - 0.15 11.6 0.1 0.42 10.1 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain adh_short_C2 PF13561.6 KOS21812.1 - 6.1e-52 176.5 0.1 7.5e-52 176.2 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS21812.1 - 2e-49 167.7 0.0 2.6e-49 167.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS21812.1 - 1.1e-10 41.7 0.2 3.1e-10 40.3 0.1 1.7 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 KOS21812.1 - 0.0056 16.2 0.2 0.021 14.3 0.2 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N PF00107.26 KOS21812.1 - 0.017 15.1 0.1 0.036 14.1 0.1 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 KOS21812.1 - 0.05 12.9 0.3 0.1 11.9 0.1 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 KOS21812.1 - 0.068 12.8 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 KOS21812.1 - 0.12 12.9 0.7 1.2 9.8 0.2 2.5 2 2 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent SNARE PF05739.19 KOS21813.1 - 4.2e-12 45.9 0.0 9e-12 44.8 0.0 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin-5_N PF11416.8 KOS21813.1 - 3.2e-09 35.8 1.9 3.2e-09 35.8 1.9 2.2 3 0 0 3 3 3 1 Syntaxin-5 N-terminal, Sly1p-binding domain Syntaxin PF00804.25 KOS21813.1 - 0.00013 21.7 3.3 0.0016 18.1 0.2 2.5 2 0 0 2 2 2 1 Syntaxin Sporozoite_P67 PF05642.11 KOS21813.1 - 0.0013 16.9 5.2 0.0015 16.7 5.2 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen KxDL PF10241.9 KOS21813.1 - 0.0014 18.9 1.7 0.33 11.3 0.1 3.2 4 0 0 4 4 4 1 Uncharacterized conserved protein TRPM_tetra PF16519.5 KOS21813.1 - 0.015 15.4 0.2 0.091 12.9 0.0 2.3 2 0 0 2 2 2 0 Tetramerisation domain of TRPM NPV_P10 PF05531.12 KOS21813.1 - 0.11 13.0 3.0 19 5.8 0.1 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4988 PF16378.5 KOS21813.1 - 0.19 11.4 3.5 14 5.3 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function MCPsignal PF00015.21 KOS21813.1 - 0.7 9.7 5.2 0.31 10.8 0.5 2.3 2 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SlyX PF04102.12 KOS21813.1 - 3 8.5 6.7 5.6 7.7 0.1 3.4 3 0 0 3 3 3 0 SlyX Aldo_ket_red PF00248.21 KOS21814.1 - 2.8e-29 102.3 0.1 1.5e-13 50.6 0.0 3.0 1 1 1 2 2 2 2 Aldo/keto reductase family NmrA PF05368.13 KOS21814.1 - 0.049 13.2 0.0 1.6 8.2 0.0 2.1 2 0 0 2 2 2 0 NmrA-like family Il2rg PF15874.5 KOS21814.1 - 0.15 12.4 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative Interleukin 2 receptor, gamma chain Abhydrolase_1 PF00561.20 KOS21815.1 - 1e-19 71.2 0.1 1.9e-19 70.3 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 KOS21815.1 - 1.7e-15 58.2 9.2 2.3e-15 57.8 9.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS21815.1 - 4.4e-09 36.0 0.0 5.5e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Sec2p PF06428.11 KOS21816.1 - 2.8e-27 94.5 22.3 4.1e-27 94.0 18.4 2.3 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p DUF5401 PF17380.2 KOS21816.1 - 0.29 9.2 15.4 0.47 8.5 15.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Golgin_A5 PF09787.9 KOS21816.1 - 0.34 10.3 24.8 0.57 9.6 24.8 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 VPS11_C PF12451.8 KOS21816.1 - 5.9 7.2 5.3 1.5 9.1 1.1 2.2 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal PRP21_like_P PF12230.8 KOS21817.1 - 2e-52 178.2 7.3 3e-28 99.2 1.1 2.3 2 0 0 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 KOS21817.1 - 1.7e-40 136.8 2.6 1.3e-21 76.4 0.1 2.5 2 0 0 2 2 2 2 Surp module zf_UBZ PF18439.1 KOS21817.1 - 0.022 14.3 0.2 0.045 13.3 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger Phage_TAC_4 PF08748.11 KOS21817.1 - 0.17 12.2 2.2 4.1 7.7 0.7 2.8 2 0 0 2 2 2 0 Phage tail assembly chaperone PMT PF02366.18 KOS21818.1 - 7.7e-79 264.7 16.5 1.8e-78 263.5 16.5 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOS21818.1 - 1.4e-66 223.9 12.3 1.4e-66 223.9 12.3 2.3 2 0 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOS21818.1 - 2.7e-43 148.0 0.9 4.4e-43 147.3 0.0 1.8 2 0 0 2 2 2 1 MIR domain Plasmodium_HRP PF05403.11 KOS21818.1 - 0.017 14.9 6.1 0.028 14.2 6.1 1.2 1 0 0 1 1 1 0 Plasmodium histidine-rich protein (HRPII/III) RSN1_7TM PF02714.15 KOS21820.1 - 5e-75 252.3 23.1 9.5e-75 251.4 23.1 1.5 1 0 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 KOS21820.1 - 1.3e-38 133.0 0.0 2.3e-38 132.2 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 KOS21820.1 - 8.7e-34 116.5 1.3 8.7e-34 116.5 1.3 2.1 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport Adeno_E3_CR2 PF02439.15 KOS21820.1 - 0.73 9.6 3.9 2.9 7.7 0.4 2.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 adh_short_C2 PF13561.6 KOS21821.1 - 2.2e-44 151.8 7.6 7.3e-36 123.9 5.5 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS21821.1 - 2.4e-42 144.6 3.7 3.2e-42 144.2 3.7 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS21821.1 - 3.1e-14 53.3 1.1 4.2e-14 52.8 1.1 1.2 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 KOS21821.1 - 0.0068 16.3 0.7 0.011 15.7 0.7 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 KOS21821.1 - 0.027 14.0 0.3 0.052 13.1 0.3 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AdoHcyase_NAD PF00670.21 KOS21821.1 - 0.1 12.7 1.9 0.15 12.1 1.6 1.5 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ANAPC3 PF12895.7 KOS21822.1 - 0.11 12.8 0.5 0.42 10.9 0.3 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Glycos_transf_2 PF00535.26 KOS21824.1 - 2e-35 122.1 0.0 2.4e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 KOS21824.1 - 3.4e-14 53.3 0.0 4.6e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 KOS21824.1 - 3.8e-06 26.5 0.0 5.8e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 KOS21824.1 - 9.3e-05 22.0 0.0 0.00012 21.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 KOS21824.1 - 0.058 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 TMA7 PF09072.10 KOS21825.1 - 3.4e-27 95.1 16.0 3.8e-27 94.9 16.0 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 Nefa_Nip30_N PF10187.9 KOS21825.1 - 0.0073 16.6 0.6 0.0088 16.4 0.6 1.1 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Pkinase PF00069.25 KOS21826.1 - 6.4e-49 166.7 0.0 8.9e-49 166.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS21826.1 - 1.2e-21 77.2 0.0 1.9e-21 76.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 KOS21826.1 - 0.012 14.6 0.1 0.018 14.0 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase RIO1 PF01163.22 KOS21826.1 - 0.027 14.1 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 KOS21826.1 - 0.11 12.4 0.0 0.25 11.2 0.0 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family ELYS-bb PF16687.5 KOS21827.1 - 0.0088 14.7 0.0 0.015 14.0 0.0 1.2 1 0 0 1 1 1 1 beta-propeller of ELYS nucleoporin ANAPC4_WD40 PF12894.7 KOS21827.1 - 0.017 15.4 0.1 3.3 8.1 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS21827.1 - 0.089 13.7 0.7 40 5.3 0.0 3.6 3 0 0 3 3 3 0 WD domain, G-beta repeat HlyIII PF03006.20 KOS21828.1 - 3.8e-63 213.2 13.1 4.5e-63 212.9 13.1 1.0 1 0 0 1 1 1 1 Haemolysin-III related DUF418 PF04235.12 KOS21828.1 - 0.35 10.8 8.4 0.14 12.1 1.8 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF418) Yip1 PF04893.17 KOS21828.1 - 0.84 9.3 24.3 0.28 10.9 14.7 2.8 1 1 1 2 2 2 0 Yip1 domain DUF962 PF06127.11 KOS21828.1 - 4.4 7.5 6.3 1.6 8.9 2.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF962) Bax1-I PF01027.20 KOS21828.1 - 7.5 6.3 13.2 14 5.5 12.3 1.8 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Syntaxin_2 PF14523.6 KOS21829.1 - 1e-22 80.4 4.0 1e-22 80.4 4.0 2.2 2 0 0 2 2 2 1 Syntaxin-like protein SNARE PF05739.19 KOS21829.1 - 2.8e-11 43.3 2.1 3.1e-11 43.1 0.7 1.9 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 KOS21829.1 - 0.015 15.0 12.4 0.045 13.4 2.4 2.6 2 1 0 2 2 2 0 Syntaxin UPF0193 PF05250.11 KOS21829.1 - 0.026 14.3 0.3 0.038 13.8 0.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0193) DUF883 PF05957.13 KOS21829.1 - 0.065 13.8 8.2 0.45 11.2 0.0 3.2 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) YabA PF06156.13 KOS21829.1 - 0.67 10.6 3.5 0.83 10.3 0.4 2.5 2 1 0 2 2 2 0 Initiation control protein YabA T3SSipB PF16535.5 KOS21829.1 - 1.2 9.6 9.7 0.18 12.3 2.0 2.8 2 1 1 3 3 3 0 Type III cell invasion protein SipB 60KD_IMP PF02096.20 KOS21830.1 - 0.14 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 60Kd inner membrane protein PIG-H PF10181.9 KOS21831.1 - 1.1e-26 92.5 0.1 1.7e-26 91.9 0.1 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component PseudoU_synth_1 PF01416.20 KOS21832.1 - 1.1e-33 115.9 0.0 6.2e-33 113.5 0.0 2.2 2 0 0 2 2 2 1 tRNA pseudouridine synthase Snf7 PF03357.21 KOS21833.1 - 4.3e-22 78.5 4.1 4.3e-22 78.5 4.1 2.1 2 0 0 2 2 2 1 Snf7 SQS_PSY PF00494.19 KOS21833.1 - 0.00064 19.3 1.9 0.072 12.6 0.5 2.2 2 0 0 2 2 2 2 Squalene/phytoene synthase Tnp_P_element PF12017.8 KOS21833.1 - 0.036 13.5 0.1 0.049 13.0 0.1 1.1 1 0 0 1 1 1 0 Transposase protein V_ATPase_I PF01496.19 KOS21833.1 - 0.55 8.1 1.5 0.76 7.6 1.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fib_alpha PF08702.10 KOS21833.1 - 0.87 9.8 6.5 0.22 11.7 2.9 1.8 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 KOS21833.1 - 1.2 8.4 11.1 0.043 13.2 4.4 1.8 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding Guanylin PF02058.15 KOS21834.1 - 0.096 13.2 0.7 0.17 12.4 0.7 1.4 1 0 0 1 1 1 0 Guanylin precursor NICE-3 PF07406.11 KOS21835.1 - 5.3e-06 26.5 1.6 0.015 15.3 0.0 2.8 2 1 1 3 3 3 2 NICE-3 protein DUF4129 PF13559.6 KOS21835.1 - 0.00015 22.0 0.1 0.00036 20.7 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) Ndc1_Nup PF09531.10 KOS21836.1 - 1.3e-181 605.5 5.8 1.4e-181 605.3 5.8 1.0 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Ras PF00071.22 KOS21837.1 - 1.8e-17 63.4 0.0 2.8e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS21837.1 - 2.9e-06 27.5 0.0 1.4e-05 25.3 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS21837.1 - 0.00017 21.1 0.0 0.00059 19.3 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 KOS21837.1 - 0.0094 15.2 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit AAA_24 PF13479.6 KOS21837.1 - 0.023 14.4 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KOS21837.1 - 0.12 11.8 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_25 PF13481.6 KOS21837.1 - 0.16 11.5 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 KOS21837.1 - 0.24 10.6 0.0 0.31 10.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_pol_Rpb4 PF03874.16 KOS21838.1 - 5.1e-25 88.2 0.0 5.9e-25 88.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb4 Polysacc_deac_2 PF04748.13 KOS21838.1 - 0.0072 15.5 0.1 0.014 14.6 0.0 1.6 2 0 0 2 2 2 1 Divergent polysaccharide deacetylase HTH_32 PF13565.6 KOS21838.1 - 0.018 15.7 0.7 0.028 15.0 0.1 1.6 2 0 0 2 2 2 0 Homeodomain-like domain CHASE6_C PF17150.4 KOS21838.1 - 0.12 13.0 1.7 0.13 12.9 0.6 1.6 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain GatB_Yqey PF02637.18 KOS21838.1 - 0.12 12.2 0.0 0.22 11.4 0.0 1.4 1 1 0 1 1 1 0 GatB domain ERAP1_C PF11838.8 KOS21839.1 - 4.3e-80 269.6 0.0 8.7e-80 268.6 0.0 1.5 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Peptidase_M1 PF01433.20 KOS21839.1 - 6.7e-80 267.7 3.1 9.3e-80 267.3 3.1 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 KOS21839.1 - 1.6e-44 152.3 0.0 3.5e-44 151.2 0.0 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF45 PF01863.17 KOS21839.1 - 0.17 11.9 0.5 0.6 10.1 0.5 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF45 PRP38_assoc PF12871.7 KOS21840.1 - 0.1 13.2 17.3 0.19 12.4 17.3 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term GYF PF02213.16 KOS21840.1 - 0.11 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 GYF domain SDA1 PF05285.12 KOS21841.1 - 3.2e-93 312.9 46.0 3.2e-93 312.9 46.0 2.5 2 1 0 2 2 2 1 SDA1 NUC130_3NT PF08158.12 KOS21841.1 - 3.7e-22 78.4 0.0 1e-21 77.0 0.0 1.8 1 0 0 1 1 1 1 NUC130/3NT domain Mating_N PF12731.7 KOS21841.1 - 0.013 15.6 0.2 0.061 13.4 0.0 2.1 2 0 0 2 2 2 0 Mating-type protein beta 1 Mito_carr PF00153.27 KOS21842.1 - 4.2e-44 148.4 8.0 6.4e-16 58.1 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein P21-Arc PF04062.14 KOS21845.1 - 3e-72 242.3 0.0 3.5e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit SSFA2_C PF14723.6 KOS21845.1 - 9.6 6.1 7.4 4.1 7.3 0.6 2.3 2 0 0 2 2 2 0 Sperm-specific antigen 2 C-terminus Gcd10p PF04189.13 KOS21846.1 - 1.7e-109 365.6 0.0 2.5e-109 365.0 0.0 1.2 1 0 0 1 1 1 1 Gcd10p family DUF3824 PF12868.7 KOS21846.1 - 0.017 15.8 7.8 0.035 14.8 7.8 1.5 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) RskA PF10099.9 KOS21846.1 - 1.6 9.0 17.7 0.12 12.7 11.1 2.2 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF3138 PF11336.8 KOS21846.1 - 1.8 7.1 7.6 1.2e+02 1.0 10.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3138) ASFV_J13L PF05568.11 KOS21846.1 - 3.5 7.4 7.6 7.1 6.3 7.6 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein FMO-like PF00743.19 KOS21847.1 - 6e-33 114.1 0.0 2.2e-24 85.8 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 KOS21847.1 - 4.2e-13 49.2 0.3 3.5e-10 39.6 0.4 2.8 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS21847.1 - 8e-12 45.0 0.0 7.6e-10 38.5 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS21847.1 - 5.1e-09 35.7 0.0 2.8e-07 30.0 0.0 2.5 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 KOS21847.1 - 1.6e-05 24.9 0.1 0.18 11.8 0.0 3.4 2 1 0 3 3 3 2 FAD-NAD(P)-binding DAO PF01266.24 KOS21847.1 - 2.5e-05 24.0 0.7 0.042 13.4 0.0 3.1 3 1 0 3 3 3 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS21847.1 - 0.00047 20.3 0.0 0.0015 18.7 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 KOS21847.1 - 0.06 12.6 0.1 3.2 6.9 0.0 2.7 3 0 0 3 3 3 0 Thi4 family FAD_binding_3 PF01494.19 KOS21847.1 - 0.11 11.7 0.9 0.12 11.6 0.1 1.4 2 0 0 2 2 2 0 FAD binding domain MFS_1 PF07690.16 KOS21848.1 - 1.4e-20 73.6 25.5 1.4e-20 73.6 25.5 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS21848.1 - 2.4e-06 26.7 4.4 2.4e-06 26.7 4.4 3.3 2 1 1 3 3 3 1 Sugar (and other) transporter DUF2811 PF10929.8 KOS21848.1 - 0.014 15.7 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2811) TRIQK PF15168.6 KOS21848.1 - 0.082 12.8 0.9 0.52 10.2 0.4 2.6 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family COX6A PF02046.15 KOS21849.1 - 3.8e-40 136.8 8.1 9.7e-40 135.5 8.1 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIa ANAPC5 PF12862.7 KOS21850.1 - 4.1e-32 110.1 3.4 9.8e-32 108.9 3.4 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 5 TPR_19 PF14559.6 KOS21850.1 - 3.1e-06 27.6 6.0 3.2 8.3 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOS21850.1 - 3.9e-05 23.4 1.0 6.6 7.0 0.0 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 KOS21850.1 - 4e-05 23.1 0.3 0.00014 21.4 0.3 1.9 1 0 0 1 1 1 1 MalT-like TPR region TPR_14 PF13428.6 KOS21850.1 - 0.00021 21.8 11.6 0.97 10.4 0.0 6.8 7 0 0 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS21850.1 - 0.00069 19.8 0.4 2 8.7 0.0 4.0 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 KOS21850.1 - 0.0015 18.5 3.6 0.88 9.8 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS21850.1 - 0.0046 17.6 11.6 0.79 10.4 0.0 5.2 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOS21850.1 - 0.0074 16.1 7.4 2.1 8.3 0.5 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21850.1 - 0.0085 16.2 0.1 6.6 7.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS21850.1 - 0.012 15.9 9.7 1.5 9.2 0.0 5.0 3 1 2 5 5 5 0 Tetratricopeptide repeat PPR PF01535.20 KOS21850.1 - 0.13 12.5 0.0 5.3 7.5 0.0 3.6 4 0 0 4 4 3 0 PPR repeat TPR_1 PF00515.28 KOS21850.1 - 0.16 11.8 4.2 18 5.3 0.0 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Med31 PF05669.12 KOS21850.1 - 0.19 11.7 1.4 2 8.5 1.4 2.4 1 1 0 1 1 1 0 SOH1 TPR_4 PF07721.14 KOS21850.1 - 0.42 11.4 0.1 0.42 11.4 0.1 5.6 6 0 0 6 6 4 0 Tetratricopeptide repeat CIA30 PF08547.12 KOS21851.1 - 6.8e-42 143.2 0.0 9.6e-42 142.7 0.0 1.2 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) CBM_11 PF03425.13 KOS21851.1 - 0.011 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain (family 11) Tim44 PF04280.15 KOS21852.1 - 1e-05 25.7 0.0 1.8e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Tim44-like domain RRM_1 PF00076.22 KOS21853.1 - 2.7e-07 30.3 0.0 5.7e-07 29.3 0.0 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SSF PF00474.17 KOS21854.1 - 2.3e-07 30.1 27.9 3.3e-06 26.2 27.9 2.1 1 1 0 1 1 1 1 Sodium:solute symporter family TPPK_C PF12555.8 KOS21854.1 - 0.0094 16.0 1.2 0.0094 16.0 1.2 4.2 5 0 0 5 5 5 1 Thiamine pyrophosphokinase C terminal EOS1 PF12326.8 KOS21855.1 - 5.2e-17 62.3 3.3 5.2e-17 62.3 3.3 2.6 2 1 1 3 3 3 2 N-glycosylation protein DUF4050 PF13259.6 KOS21855.1 - 0.19 12.0 0.6 0.29 11.4 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) SLATT_1 PF18181.1 KOS21855.1 - 5.3 7.0 7.6 3.3 7.6 1.0 2.6 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 SUI1 PF01253.22 KOS21856.1 - 4.5e-27 94.4 2.2 6.2e-27 93.9 2.2 1.2 1 0 0 1 1 1 1 Translation initiation factor SUI1 AdoMet_MTase PF07757.13 KOS21857.1 - 8.8e-35 119.4 0.0 3.9e-34 117.4 0.0 1.9 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Dioxygenase_C PF00775.21 KOS21858.1 - 2.2e-40 138.1 0.0 2.8e-40 137.7 0.0 1.2 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 KOS21858.1 - 1.9e-20 72.5 0.0 3.1e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 KOS21858.1 - 1.1e-05 25.6 0.0 3.2e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain SpaA PF17802.1 KOS21858.1 - 0.00064 20.0 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Prealbumin-like fold domain CarbopepD_reg_2 PF13715.6 KOS21858.1 - 0.079 13.0 0.1 14 5.7 0.0 2.6 1 1 1 2 2 2 0 CarboxypepD_reg-like domain His_Phos_1 PF00300.22 KOS21859.1 - 5e-37 127.5 0.8 7.8e-18 64.9 0.1 2.6 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) UCH PF00443.29 KOS21861.1 - 2e-49 168.4 0.2 3.9e-49 167.4 0.2 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS21861.1 - 4.7e-14 52.7 8.3 5e-13 49.3 8.3 2.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 KOS21861.1 - 2.9e-12 46.2 0.1 7.5e-12 44.8 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin family DUF4746 PF15928.5 KOS21861.1 - 0.16 11.4 9.8 0.28 10.6 9.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MAJIN PF15077.6 KOS21861.1 - 0.76 9.5 7.9 1.8 8.3 7.9 1.6 1 0 0 1 1 1 0 Membrane-anchored junction protein Zip PF02535.22 KOS21861.1 - 1.9 7.6 4.0 2.8 7.1 4.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 KOS21861.1 - 3.4 7.7 18.5 12 5.9 16.5 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 PIEZO PF15917.5 KOS21861.1 - 3.6 7.0 9.8 7.1 6.0 9.8 1.4 1 0 0 1 1 1 0 Piezo OAD_gamma PF04277.13 KOS21861.1 - 4.3 8.0 7.7 2.6 8.7 4.5 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain V_ATPase_I PF01496.19 KOS21861.1 - 6 4.6 5.6 9.5 4.0 5.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ARPC4 PF05856.12 KOS21862.1 - 3.1e-78 261.2 3.6 3.4e-78 261.0 3.6 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) CRAL_TRIO PF00650.20 KOS21865.1 - 2.6e-16 59.7 0.0 3.7e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOS21865.1 - 1.2e-06 28.6 0.0 2.6e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain UPF0225 PF17775.1 KOS21865.1 - 0.059 14.2 0.1 0.16 12.8 0.1 1.7 1 0 0 1 1 1 0 UPF0225 domain PRA-PH PF01503.17 KOS21865.1 - 2.3 8.7 6.1 13 6.3 0.0 2.6 2 1 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase SET PF00856.28 KOS21866.1 - 1.2e-14 55.0 1.1 1.2e-14 55.0 1.1 3.0 2 1 0 2 2 2 1 SET domain AWS PF17907.1 KOS21866.1 - 5.4e-07 29.5 6.0 1.5e-06 28.1 6.0 1.8 1 0 0 1 1 1 1 AWS domain GAGA_bind PF06217.12 KOS21867.1 - 0.66 10.2 8.3 1.1 9.4 8.3 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family DHHC PF01529.20 KOS21868.1 - 8.6e-27 93.9 3.6 8.6e-27 93.9 3.6 2.3 2 0 0 2 2 2 1 DHHC palmitoyltransferase Glucos_trans_II PF14264.6 KOS21868.1 - 0.00028 20.4 9.0 0.029 13.7 0.1 2.1 2 0 0 2 2 2 2 Glucosyl transferase GtrII DUF4131 PF13567.6 KOS21868.1 - 0.0046 16.6 6.8 0.26 10.9 2.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4131) DUF412 PF04217.13 KOS21868.1 - 0.045 13.6 0.3 0.11 12.4 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF412 OAD_gamma PF04277.13 KOS21868.1 - 0.12 13.0 1.1 1 10.0 0.0 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF1422 PF07226.11 KOS21868.1 - 0.28 11.2 10.5 0.2 11.7 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1422) YfhO PF09586.10 KOS21868.1 - 0.55 8.4 5.4 1 7.5 2.1 2.0 2 0 0 2 2 2 0 Bacterial membrane protein YfhO AA_permease_2 PF13520.6 KOS21868.1 - 0.6 8.9 10.9 0.12 11.1 1.4 2.0 2 0 0 2 2 2 0 Amino acid permease Cyt_bd_oxida_II PF02322.15 KOS21868.1 - 0.83 9.0 10.7 2.2 7.6 0.6 2.1 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF2162 PF09930.9 KOS21868.1 - 0.99 8.8 10.8 0.69 9.3 1.7 2.2 2 0 0 2 2 2 0 Predicted transporter (DUF2162) CPP1-like PF11833.8 KOS21868.1 - 1.2 8.8 6.1 2.3 7.8 0.7 2.2 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like ABC2_membrane_3 PF12698.7 KOS21868.1 - 2.5 7.1 16.6 2.1 7.4 5.3 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF3810 PF12725.7 KOS21868.1 - 2.5 7.4 8.8 3.2 7.0 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Phage_holin_3_6 PF07332.11 KOS21868.1 - 2.6 8.1 10.5 14 5.8 4.8 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Polysacc_synt_C PF14667.6 KOS21868.1 - 6.7 6.8 14.0 7.1 6.7 1.0 2.2 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Sugar_tr PF00083.24 KOS21868.1 - 7 5.4 14.5 2.3 7.0 3.3 2.1 2 0 0 2 2 2 0 Sugar (and other) transporter Ank_2 PF12796.7 KOS21869.1 - 5.1e-24 84.7 0.0 5.5e-13 49.3 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS21869.1 - 6.1e-13 49.0 0.0 2.4e-12 47.1 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS21869.1 - 1.4e-11 43.5 0.0 1.1e-06 28.5 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOS21869.1 - 2.5e-10 40.4 0.1 5.3e-10 39.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOS21869.1 - 1e-09 38.4 0.0 2.6e-08 34.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat TFIIB PF00382.19 KOS21870.1 - 1.4e-30 105.1 0.5 2.5e-19 69.1 0.1 2.6 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 KOS21870.1 - 7.4e-24 84.0 1.3 7.4e-24 84.0 1.3 3.3 4 0 0 4 4 4 1 Brf1-like TBP-binding domain Cyclin_N PF00134.23 KOS21870.1 - 0.0003 20.5 0.6 0.018 14.8 0.1 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain Rtf2 PF04641.12 KOS21870.1 - 3 7.1 10.3 0.29 10.5 0.3 2.5 2 0 0 2 2 2 0 Rtf2 RING-finger Pkinase PF00069.25 KOS21871.1 - 0.0059 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CDC45 PF02724.14 KOS21871.1 - 0.0094 14.3 5.2 0.012 14.0 5.2 1.1 1 0 0 1 1 1 1 CDC45-like protein Tim54 PF11711.8 KOS21871.1 - 0.028 13.2 3.1 0.038 12.8 3.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 APH PF01636.23 KOS21871.1 - 0.1 12.5 1.9 0.62 9.9 0.4 2.4 2 1 0 2 2 2 0 Phosphotransferase enzyme family DNA_pol_phi PF04931.13 KOS21871.1 - 0.16 10.0 7.6 0.22 9.6 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Zip PF02535.22 KOS21871.1 - 0.17 11.1 0.3 0.21 10.8 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 KOS21871.1 - 0.31 11.5 6.5 0.56 10.6 6.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop14 PF04147.12 KOS21871.1 - 0.39 8.9 13.0 0.53 8.4 13.0 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 KOS21871.1 - 0.41 9.4 2.9 0.58 8.9 2.9 1.1 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 KOS21871.1 - 0.41 10.7 2.6 0.63 10.1 2.6 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein CPSF100_C PF13299.6 KOS21871.1 - 1.4 9.1 7.5 2.3 8.4 7.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_polI_A34 PF08208.11 KOS21871.1 - 2.5 8.2 18.4 3.7 7.6 18.4 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Connexin PF00029.19 KOS21871.1 - 3.7 7.2 6.8 5.9 6.6 6.8 1.2 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 KOS21871.1 - 6.4 6.5 12.2 9.5 6.0 12.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SQS_PSY PF00494.19 KOS21872.1 - 9.2e-56 189.2 3.5 1.2e-55 188.8 3.5 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase Amino_oxidase PF01593.24 KOS21873.1 - 1.1e-29 104.1 0.0 6.5e-29 101.5 0.0 1.9 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS21873.1 - 3.5e-16 59.2 0.1 1.7e-15 57.0 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS21873.1 - 1.1e-08 34.7 0.0 2.3e-08 33.6 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS21873.1 - 8.7e-08 32.1 2.1 1.4e-06 28.2 2.1 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS21873.1 - 2.2e-07 30.3 1.8 7.6e-07 28.5 2.1 1.8 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KOS21873.1 - 8e-07 28.8 0.0 1.1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS21873.1 - 1.8e-06 27.0 0.1 0.00021 20.1 0.4 2.3 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 KOS21873.1 - 1.8e-05 24.2 0.2 7.5e-05 22.1 0.4 1.8 2 0 0 2 2 2 1 FAD binding domain Thi4 PF01946.17 KOS21873.1 - 0.00013 21.2 0.0 0.00021 20.6 0.0 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 KOS21873.1 - 0.00042 20.8 1.4 0.0011 19.5 0.9 2.0 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS21873.1 - 0.0012 18.2 0.7 0.0019 17.5 0.7 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOS21873.1 - 0.0017 17.5 1.8 0.0035 16.5 1.8 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_9 PF13454.6 KOS21873.1 - 0.0019 18.2 0.4 0.016 15.2 0.3 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding ApbA PF02558.16 KOS21873.1 - 0.0086 15.7 0.5 0.016 14.8 0.5 1.6 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Lycopene_cycl PF05834.12 KOS21873.1 - 0.031 13.3 0.4 0.056 12.5 0.4 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Trp_halogenase PF04820.14 KOS21873.1 - 0.037 12.9 1.2 0.26 10.1 1.2 2.0 2 0 0 2 2 2 0 Tryptophan halogenase TrkA_N PF02254.18 KOS21873.1 - 0.1 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_7 PF13241.6 KOS21873.1 - 0.18 12.2 0.0 0.3 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 KOS21873.1 - 0.2 11.5 1.1 0.34 10.8 1.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain MCRA PF06100.11 KOS21873.1 - 0.22 10.3 0.0 0.42 9.4 0.0 1.5 2 0 0 2 2 2 0 MCRA family Asp PF00026.23 KOS21874.1 - 1.6e-73 247.9 5.5 2e-73 247.6 5.5 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS21874.1 - 7.5e-09 36.1 7.0 4.6e-08 33.5 1.5 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOS21874.1 - 0.013 15.3 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Xylanase inhibitor C-terminal PP2C PF00481.21 KOS21875.1 - 1.9e-24 86.7 0.0 3e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Brix PF04427.18 KOS21876.1 - 4.1e-49 167.3 0.0 5.2e-49 167.0 0.0 1.1 1 0 0 1 1 1 1 Brix domain DUF1168 PF06658.12 KOS21876.1 - 0.83 9.5 17.6 0.032 14.1 10.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) PPL5 PF18168.1 KOS21876.1 - 6.2 6.0 8.2 5.1 6.3 6.5 1.7 1 1 0 1 1 1 0 Prim-pol family 5 CsbD PF05532.12 KOS21877.1 - 3.1e-07 30.2 5.2 0.0038 17.1 0.6 2.2 2 0 0 2 2 2 2 CsbD-like Sdh_cyt PF01127.22 KOS21878.1 - 8.5 6.4 10.2 0.14 12.2 2.2 2.1 3 0 0 3 3 3 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit MMU163 PF17119.5 KOS21879.1 - 6.6e-75 251.5 5.2 3.8e-54 183.5 2.3 2.1 1 1 1 2 2 2 2 Mitochondrial protein up-regulated during meiosis Tom5 PF10642.9 KOS21879.1 - 0.77 9.8 0.1 0.77 9.8 0.1 2.5 2 0 0 2 2 2 0 Mitochondrial import receptor subunit or translocase Mito_fiss_reg PF05308.11 KOS21879.1 - 7.8 6.5 8.6 15 5.6 8.6 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator Mpp10 PF04006.12 KOS21880.1 - 5.6 5.3 17.9 5.5 5.3 17.9 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 KOS21880.1 - 6.5 4.8 23.7 6.4 4.9 23.7 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 KOS21880.1 - 6.6 4.9 20.7 6.6 4.9 20.7 1.0 1 0 0 1 1 1 0 CDC45-like protein RNase_PH PF01138.21 KOS21882.1 - 5.9e-09 36.5 0.0 5.8e-08 33.3 0.0 2.3 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 KOS21882.1 - 0.0059 16.6 0.0 0.011 15.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 NUDIX PF00293.28 KOS21883.1 - 1.5e-06 28.3 0.8 1.8e-06 28.0 0.8 1.1 1 0 0 1 1 1 1 NUDIX domain Tox-MPTase3 PF15639.6 KOS21883.1 - 0.012 15.5 0.0 0.014 15.2 0.0 1.2 1 0 0 1 1 1 0 Metallopeptidase toxin 3 LSM PF01423.22 KOS21884.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 LSM domain Cir_N PF10197.9 KOS21884.1 - 0.58 10.4 6.8 0.81 9.9 6.8 1.2 1 0 0 1 1 1 0 N-terminal domain of CBF1 interacting co-repressor CIR Fructosamin_kin PF03881.14 KOS21885.1 - 1.6e-50 171.9 0.0 2.3e-50 171.5 0.0 1.2 1 0 0 1 1 1 1 Fructosamine kinase APH PF01636.23 KOS21885.1 - 2.3e-06 27.7 3.5 4.4e-06 26.8 3.4 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Snf7 PF03357.21 KOS21886.1 - 7.5e-33 113.5 5.8 8.8e-33 113.3 5.8 1.0 1 0 0 1 1 1 1 Snf7 AAA PF00004.29 KOS21887.1 - 7.8e-63 210.8 0.0 3.2e-45 153.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS21887.1 - 1.1e-12 47.5 2.4 3.7e-06 26.6 0.1 3.0 3 0 0 3 3 3 2 AAA+ lid domain AAA_16 PF13191.6 KOS21887.1 - 6.7e-09 36.4 6.4 0.011 16.1 0.0 5.3 4 2 2 6 6 6 2 AAA ATPase domain AAA_33 PF13671.6 KOS21887.1 - 1.4e-08 35.0 0.0 0.0052 17.0 0.0 2.8 2 1 0 2 2 2 2 AAA domain RuvB_N PF05496.12 KOS21887.1 - 1.7e-08 34.4 0.0 0.0021 17.8 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 KOS21887.1 - 5.3e-08 32.9 0.1 0.0013 18.7 0.0 3.2 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 KOS21887.1 - 1.2e-06 28.8 0.0 0.008 16.5 0.0 3.6 3 1 0 3 3 2 1 AAA domain AAA_2 PF07724.14 KOS21887.1 - 4.3e-05 23.7 0.0 0.00021 21.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 KOS21887.1 - 0.00029 21.4 0.0 0.91 10.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 KOS21887.1 - 0.00065 20.1 0.0 0.2 12.1 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Rad17 PF03215.15 KOS21887.1 - 0.00089 19.2 0.0 0.84 9.5 0.1 2.8 2 1 0 2 2 2 1 Rad17 P-loop domain Mg_chelatase PF01078.21 KOS21887.1 - 0.0016 17.9 0.2 0.34 10.2 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 KOS21887.1 - 0.0019 18.2 0.0 0.01 15.9 0.0 2.2 3 0 0 3 3 1 1 AAA domain DUF815 PF05673.13 KOS21887.1 - 0.0025 17.0 0.0 2.3 7.3 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_17 PF13207.6 KOS21887.1 - 0.003 18.0 0.0 2 8.9 0.0 2.8 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 KOS21887.1 - 0.0047 16.7 0.0 0.28 10.9 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_28 PF13521.6 KOS21887.1 - 0.015 15.6 0.1 5.9 7.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 KOS21887.1 - 0.015 15.0 0.0 7.5 6.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain TniB PF05621.11 KOS21887.1 - 0.019 14.4 0.0 9.4 5.6 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein AAA_25 PF13481.6 KOS21887.1 - 0.034 13.7 0.0 0.87 9.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain TsaE PF02367.17 KOS21887.1 - 0.038 14.0 0.0 12 5.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 KOS21887.1 - 0.039 13.2 0.0 0.18 11.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin TIP49 PF06068.13 KOS21887.1 - 0.046 12.9 0.0 0.53 9.4 0.0 2.1 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_7 PF12775.7 KOS21887.1 - 0.057 12.9 0.0 4.4 6.8 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Sigma54_activ_2 PF14532.6 KOS21887.1 - 0.06 13.5 0.0 0.45 10.6 0.0 2.2 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 KOS21887.1 - 0.062 13.2 0.0 4.8 7.0 0.0 2.6 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 KOS21887.1 - 0.063 13.2 0.2 2.5 8.0 0.0 2.9 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 KOS21887.1 - 0.11 13.0 1.9 2 8.9 0.0 3.3 4 1 0 4 4 2 0 ABC transporter Sigma54_activat PF00158.26 KOS21887.1 - 0.14 11.9 0.0 1.4 8.6 0.0 2.5 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_11 PF13086.6 KOS21887.1 - 0.22 11.2 0.0 0.22 11.2 0.0 3.8 3 2 0 3 3 2 0 AAA domain CCDC106 PF15794.5 KOS21887.1 - 0.26 10.9 6.2 0.6 9.8 6.2 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Dicty_REP PF05086.12 KOS21887.1 - 1.5 6.7 4.3 2.1 6.2 4.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LCD1 PF09798.9 KOS21887.1 - 3.1 6.2 5.9 4.3 5.7 5.9 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Cytochrom_C PF00034.21 KOS21888.1 - 1.1e-09 39.3 0.1 1.5e-09 38.9 0.1 1.2 1 0 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 KOS21888.1 - 3.5e-07 30.4 3.0 2.5e-06 27.7 3.0 1.9 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 KOS21888.1 - 0.0011 18.7 1.1 0.0036 17.0 0.1 2.1 2 1 0 2 2 2 1 Cytochrome c-550 domain Pyridoxal_deC PF00282.19 KOS21889.1 - 1.3e-59 201.8 0.0 9.8e-49 166.0 0.0 2.1 1 1 1 2 2 2 2 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 KOS21889.1 - 0.012 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Abhydrolase_3 PF07859.13 KOS21890.1 - 1.9e-35 122.7 0.0 2.1e-24 86.6 0.0 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Lipase_3 PF01764.25 KOS21890.1 - 0.07 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) AXE1 PF05448.12 KOS21890.1 - 0.18 10.5 0.0 0.3 9.7 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Say1_Mug180 PF10340.9 KOS21890.1 - 0.19 10.6 0.0 0.28 10.0 0.0 1.2 1 0 0 1 1 1 0 Steryl acetyl hydrolase Ufd2P_core PF10408.9 KOS21891.1 - 8.7e-203 675.4 9.9 1.1e-202 675.0 9.9 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 KOS21891.1 - 3.4e-22 78.4 1.2 1.4e-21 76.5 1.2 2.1 1 0 0 1 1 1 1 U-box domain LOH1CR12 PF10158.9 KOS21891.1 - 0.088 12.8 1.5 0.35 10.9 0.4 2.4 2 0 0 2 2 2 0 Tumour suppressor protein Fungal_trans PF04082.18 KOS21892.1 - 6.6e-21 74.5 0.2 1.2e-20 73.7 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21892.1 - 6.3e-08 32.6 13.7 1.3e-07 31.6 13.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4349 PF14257.6 KOS21892.1 - 0.017 14.6 0.1 0.033 13.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) PRKG1_interact PF15898.5 KOS21892.1 - 0.26 12.2 3.3 0.51 11.3 3.3 1.4 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain PBP_like_2 PF12849.7 KOS21893.1 - 1e-09 38.5 1.0 1.5e-09 38.0 1.0 1.2 1 0 0 1 1 1 1 PBP superfamily domain SBP_bac_11 PF13531.6 KOS21893.1 - 0.00019 21.3 0.2 0.0031 17.3 0.2 2.3 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein SBP_bac_1 PF01547.25 KOS21893.1 - 0.084 12.8 5.6 0.54 10.2 0.0 2.6 2 1 0 3 3 3 0 Bacterial extracellular solute-binding protein zf-TRAF PF02176.18 KOS21894.1 - 1.8e-10 41.4 21.8 1.9e-08 34.8 3.1 3.6 2 1 1 3 3 3 2 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 KOS21894.1 - 2.3e-08 33.7 6.2 2.3e-08 33.7 6.2 2.9 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS21894.1 - 3.5e-08 33.2 6.1 3.5e-08 33.2 6.1 2.9 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 KOS21894.1 - 9e-08 32.2 7.2 9e-08 32.2 7.2 2.8 2 1 1 3 3 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KOS21894.1 - 2.3e-07 30.7 7.3 2.3e-07 30.7 7.3 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 KOS21894.1 - 3.2e-07 30.1 3.1 3.2e-07 30.1 3.1 3.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 KOS21894.1 - 1.9e-06 28.1 6.4 1.9e-06 28.1 6.4 3.5 3 2 1 4 4 2 1 Ring finger domain zf-RING_5 PF14634.6 KOS21894.1 - 6.8e-06 26.0 3.2 6.8e-06 26.0 3.2 3.2 3 0 0 3 3 3 1 zinc-RING finger domain zf-Nse PF11789.8 KOS21894.1 - 0.0024 17.6 2.6 0.0024 17.6 2.6 2.9 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit zf-rbx1 PF12678.7 KOS21894.1 - 0.0043 17.3 1.3 0.0043 17.3 1.3 3.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain Sina PF03145.16 KOS21894.1 - 0.0051 16.8 2.3 0.0051 16.8 2.3 3.6 2 1 1 4 4 4 2 Seven in absentia protein family zf-ANAPC11 PF12861.7 KOS21894.1 - 0.015 15.3 1.3 0.015 15.3 1.3 2.9 3 0 0 3 3 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Herpes_TK PF00693.18 KOS21894.1 - 0.042 13.1 0.1 0.074 12.3 0.1 1.3 1 0 0 1 1 1 0 Thymidine kinase from herpesvirus zf-RING_10 PF16685.5 KOS21894.1 - 0.52 10.5 11.8 0.038 14.1 5.0 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-TRAF_2 PF15965.5 KOS21894.1 - 1.4 9.5 23.6 1 9.8 0.9 3.4 1 1 2 3 3 3 0 TRAF-like zinc-finger zf-RING_6 PF14835.6 KOS21894.1 - 2.7 7.9 7.5 0.35 10.8 2.9 2.0 2 0 0 2 2 1 0 zf-RING of BARD1-type protein Ald_Xan_dh_C2 PF02738.18 KOS21895.1 - 6.2e-208 691.7 0.6 1e-207 691.0 0.6 1.3 1 0 0 1 1 1 1 Molybdopterin-binding domain of aldehyde dehydrogenase FAD_binding_5 PF00941.21 KOS21895.1 - 2.8e-46 157.4 0.0 6.7e-46 156.1 0.0 1.6 1 0 0 1 1 1 1 FAD binding domain in molybdopterin dehydrogenase Ald_Xan_dh_C PF01315.22 KOS21895.1 - 3.1e-31 108.0 0.0 7e-31 106.8 0.0 1.7 1 0 0 1 1 1 1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain CO_deh_flav_C PF03450.17 KOS21895.1 - 1.3e-30 105.6 0.9 5.7e-30 103.5 0.1 2.5 2 0 0 2 2 2 1 CO dehydrogenase flavoprotein C-terminal domain Fer2_2 PF01799.20 KOS21895.1 - 2.4e-29 101.2 0.1 5.8e-29 99.9 0.1 1.7 1 0 0 1 1 1 1 [2Fe-2S] binding domain Fer2 PF00111.27 KOS21895.1 - 2e-07 30.8 0.1 2e-07 30.8 0.1 2.4 2 1 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain CxC7 PF18866.1 KOS21895.1 - 0.14 12.3 0.4 0.62 10.2 0.0 2.2 2 0 0 2 2 2 0 CxC7 like cysteine cluster associated with KDZ transposases Aminotran_1_2 PF00155.21 KOS21896.1 - 3.6e-57 194.2 0.0 4.6e-57 193.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOS21896.1 - 0.00027 20.4 0.0 0.00055 19.4 0.0 1.4 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 KOS21896.1 - 0.00076 18.1 0.0 0.0028 16.3 0.0 1.7 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 KOS21896.1 - 0.0019 17.6 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 KOS21896.1 - 0.038 12.9 0.0 0.069 12.1 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V SPO22 PF08631.10 KOS21897.1 - 1.5e-55 188.6 0.0 1.2e-53 182.4 0.0 2.6 2 0 0 2 2 2 2 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 KOS21897.1 - 0.0014 18.9 0.6 0.029 14.7 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat Latarcin PF10279.9 KOS21897.1 - 0.13 12.7 0.0 7.4 7.0 0.0 2.8 2 0 0 2 2 2 0 Latarcin precursor DUF104 PF01954.16 KOS21898.1 - 0.017 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF104 PAS PF00989.25 KOS21898.1 - 0.16 11.9 0.0 0.31 11.0 0.0 1.5 1 0 0 1 1 1 0 PAS fold MerR PF00376.23 KOS21898.1 - 0.22 11.3 0.8 55 3.6 0.0 3.3 3 0 0 3 3 3 0 MerR family regulatory protein CENP-T_C PF15511.6 KOS21899.1 - 5.1e-41 139.2 0.0 1.1e-40 138.1 0.0 1.6 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 KOS21899.1 - 1.4e-08 35.0 0.0 2.4e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein Histone PF00125.24 KOS21899.1 - 2.7e-07 31.0 0.2 9e-07 29.3 0.0 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 KOS21899.1 - 0.0086 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 KOS21899.1 - 0.036 14.1 0.0 0.066 13.2 0.0 1.3 1 0 0 1 1 1 0 Bromodomain associated Thr_dehydrat_C PF00585.18 KOS21900.1 - 0.2 11.4 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase dsDNA_bind PF01984.20 KOS21901.1 - 1.5e-37 128.2 7.1 1.8e-37 128.0 7.1 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Fes1 PF08609.10 KOS21901.1 - 0.14 13.1 2.4 0.24 12.3 0.4 2.0 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 ApbA_C PF08546.11 KOS21902.1 - 9.8e-16 58.1 0.0 1.6e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 KOS21902.1 - 2.4e-07 30.5 0.0 5.1e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA DUF4013 PF13197.6 KOS21903.1 - 0.011 15.6 6.9 0.016 15.1 6.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4013) Coq4 PF05019.13 KOS21904.1 - 2.5e-90 301.6 0.0 2.9e-90 301.4 0.0 1.0 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 UBX PF00789.20 KOS21905.1 - 1.3e-13 50.9 0.0 2.4e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain DUF4834 PF16118.5 KOS21905.1 - 0.22 12.5 4.9 3 8.8 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RRM_3 PF08777.11 KOS21905.1 - 0.53 10.4 8.6 55 3.9 0.0 3.2 3 0 0 3 3 3 0 RNA binding motif SURF1 PF02104.15 KOS21906.1 - 9.2e-44 149.8 0.1 1.1e-43 149.5 0.1 1.1 1 0 0 1 1 1 1 SURF1 family Sas10_Utp3 PF04000.15 KOS21907.1 - 6.8e-15 55.5 0.5 6.8e-15 55.5 0.5 2.1 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DUF4140 PF13600.6 KOS21907.1 - 0.15 12.5 7.2 1.7 9.1 5.0 2.5 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2076 PF09849.9 KOS21908.1 - 1.4e-09 38.4 7.7 1.7e-09 38.1 7.7 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CHCH PF06747.13 KOS21908.1 - 0.0019 18.3 2.3 0.0023 18.0 1.2 1.7 1 1 1 2 2 2 2 CHCH domain Trypan_glycop_C PF10659.9 KOS21908.1 - 0.019 15.3 0.3 0.028 14.8 0.3 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain GCK PF07802.11 KOS21908.1 - 0.027 14.9 0.4 0.042 14.3 0.3 1.4 1 1 0 1 1 1 0 GCK domain COX6B PF02297.17 KOS21908.1 - 0.03 14.5 1.4 0.045 14.0 1.4 1.2 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb CX9C PF16860.5 KOS21908.1 - 0.039 14.0 0.5 0.056 13.5 0.5 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, COX17 PF05051.13 KOS21908.1 - 0.081 13.3 0.9 0.22 11.9 0.1 1.9 1 1 1 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) DPBB_1 PF03330.18 KOS21909.1 - 5.5e-09 36.2 0.0 8.9e-09 35.5 0.0 1.4 1 1 0 1 1 1 1 Lytic transglycolase Barwin PF00967.17 KOS21909.1 - 0.016 15.1 0.4 0.027 14.3 0.4 1.5 1 1 0 1 1 1 0 Barwin family Cerato-platanin PF07249.12 KOS21909.1 - 0.098 12.8 0.0 0.16 12.1 0.0 1.4 1 1 0 1 1 1 0 Cerato-platanin CvfB_WH PF17783.1 KOS21909.1 - 0.18 11.6 0.0 0.32 10.8 0.0 1.3 1 0 0 1 1 1 0 CvfB-like winged helix domain 5_nucleotid_C PF02872.18 KOS21910.1 - 8.4e-35 120.3 0.0 1.3e-34 119.7 0.0 1.3 1 0 0 1 1 1 1 5'-nucleotidase, C-terminal domain Metallophos PF00149.28 KOS21910.1 - 0.00084 19.9 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Alginate_lyase PF05426.12 KOS21911.1 - 1.4e-85 287.1 0.1 1.8e-85 286.8 0.1 1.1 1 0 0 1 1 1 1 Alginate lyase CwfJ_C_2 PF04676.14 KOS21912.1 - 6.3e-27 94.4 0.1 1.4e-26 93.2 0.1 1.6 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 CwfJ_C_1 PF04677.15 KOS21912.1 - 7.4e-22 77.5 0.0 1.1e-21 76.9 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DLH PF01738.18 KOS21913.1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Dienelactone hydrolase family FGGY_C PF02782.16 KOS21914.1 - 3.1e-71 239.2 1.1 5.5e-71 238.4 1.1 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOS21914.1 - 1.3e-64 218.1 0.0 1.7e-64 217.8 0.0 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Fungal_trans PF04082.18 KOS21915.1 - 8.8e-18 64.3 0.0 1.6e-17 63.4 0.0 1.5 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21915.1 - 4.8e-08 33.0 9.3 9.7e-08 32.0 9.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DAO PF01266.24 KOS21916.1 - 2.2e-50 172.2 2.3 2.8e-50 171.9 0.6 1.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase DAO_C PF16901.5 KOS21916.1 - 5.5e-39 132.9 0.0 1e-38 132.0 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 KOS21916.1 - 0.00071 18.8 5.4 0.026 13.6 1.1 2.6 3 0 0 3 3 3 2 FAD binding domain 3HCDH_N PF02737.18 KOS21916.1 - 0.0011 18.8 0.1 0.002 18.1 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 KOS21916.1 - 0.0012 18.1 0.3 0.0033 16.7 0.3 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 KOS21916.1 - 0.0035 16.5 0.1 0.087 11.9 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOS21916.1 - 0.0045 16.4 2.2 0.013 14.9 0.3 2.3 3 0 0 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 KOS21916.1 - 0.0045 17.2 0.4 0.018 15.3 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOS21916.1 - 0.021 14.1 0.0 0.04 13.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOS21916.1 - 0.03 13.0 0.3 0.052 12.2 0.3 1.3 1 0 0 1 1 1 0 HI0933-like protein Thi4 PF01946.17 KOS21916.1 - 0.24 10.6 0.7 0.5 9.6 0.0 1.8 2 0 0 2 2 2 0 Thi4 family MIP PF00230.20 KOS21917.1 - 1.8e-51 175.1 8.7 2.2e-51 174.7 8.7 1.1 1 0 0 1 1 1 1 Major intrinsic protein FAD_binding_2 PF00890.24 KOS21918.1 - 1.2e-91 307.9 0.0 1.4e-91 307.7 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOS21918.1 - 5.2e-05 23.4 0.3 0.00046 20.4 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOS21918.1 - 6.8e-05 22.3 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS21918.1 - 0.0012 18.6 0.0 0.0029 17.2 0.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS21918.1 - 0.0013 18.1 0.0 0.089 12.0 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS21918.1 - 0.0041 16.4 0.0 0.0091 15.3 0.0 1.5 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 KOS21918.1 - 0.0045 15.7 1.1 0.23 10.1 0.0 2.5 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 KOS21918.1 - 0.013 14.6 0.9 0.018 14.2 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 KOS21918.1 - 0.081 12.2 0.0 0.25 10.6 0.0 1.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase CSN7a_helixI PF18392.1 KOS21919.1 - 1.8 8.5 4.6 18 5.3 0.6 2.3 2 0 0 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain Transp_cyt_pur PF02133.15 KOS21920.1 - 3.1e-80 270.1 31.5 1.2e-72 245.1 22.8 2.0 1 1 1 2 2 2 2 Permease for cytosine/purines, uracil, thiamine, allantoin DUF5506 PF17611.2 KOS21920.1 - 0.051 13.5 1.0 0.14 12.1 1.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5506) Fungal_trans PF04082.18 KOS21921.1 - 5.6e-22 78.0 0.0 1.2e-21 77.0 0.0 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS21921.1 - 2.3e-05 24.4 5.7 4.3e-05 23.5 5.7 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 KOS21921.1 - 0.18 11.8 3.2 0.07 13.1 0.5 1.7 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Thi4 PF01946.17 KOS21922.1 - 1.7e-113 377.7 0.0 2e-113 377.4 0.0 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 KOS21922.1 - 6.9e-07 29.2 0.1 9.4e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 KOS21922.1 - 7.6e-05 21.9 0.1 0.00017 20.8 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KOS21922.1 - 0.00014 22.0 0.8 0.00038 20.6 0.8 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS21922.1 - 0.0039 16.5 0.1 0.0067 15.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS21922.1 - 0.0092 16.0 0.1 0.0092 16.0 0.1 1.9 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 KOS21922.1 - 0.1 11.8 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 KOS21922.1 - 0.14 10.9 0.3 0.2 10.3 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein K_oxygenase PF13434.6 KOS21922.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 KOS21922.1 - 0.43 9.6 4.8 0.28 10.2 0.4 2.7 3 1 1 4 4 4 0 FAD binding domain DUF917 PF06032.12 KOS21923.1 - 1.6e-111 372.5 0.0 3.1e-111 371.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 KOS21923.1 - 5.8e-29 101.1 0.2 6.2e-26 91.2 0.0 3.0 2 1 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 KOS21923.1 - 6.9e-25 87.9 4.7 1.3e-20 73.9 0.4 3.6 2 1 1 3 3 3 3 Hydantoinase/oxoprolinase MutL PF13941.6 KOS21923.1 - 3.3e-07 29.3 0.4 0.00043 19.0 0.0 2.4 2 0 0 2 2 2 2 MutL protein FtsA PF14450.6 KOS21923.1 - 0.012 16.1 2.3 1.1 9.7 0.0 3.4 3 2 0 3 3 3 0 Cell division protein FtsA StbA PF06406.11 KOS21923.1 - 0.025 13.8 0.0 3.1 7.0 0.0 2.5 2 0 0 2 2 2 0 StbA protein BcrAD_BadFG PF01869.20 KOS21923.1 - 0.46 9.9 5.2 0.77 9.2 0.1 2.6 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family Pro_CA PF00484.19 KOS21924.1 - 5.9e-52 176.1 0.0 7.4e-52 175.8 0.0 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Glyco_hydro_cc PF11790.8 KOS21926.1 - 3.2e-70 236.4 0.2 3.7e-70 236.2 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Fip1 PF05182.13 KOS21926.1 - 0.0025 17.3 0.4 0.0025 17.3 0.4 2.0 2 0 0 2 2 2 1 Fip1 motif Cation_ATPase_C PF00689.21 KOS21927.1 - 1.6e-29 102.9 1.7 1.6e-29 102.9 1.7 2.1 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 KOS21927.1 - 2.3e-20 73.8 0.1 1.1e-19 71.6 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 KOS21927.1 - 1.3e-07 31.4 5.6 3e-07 30.1 2.9 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 KOS21927.1 - 2.2e-07 30.9 0.3 2.1e-05 24.4 0.3 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase p450 PF00067.22 KOS21929.1 - 1.6e-57 195.3 0.0 1.4e-44 152.6 0.0 2.1 1 1 1 2 2 2 2 Cytochrome P450 GTA_holin_3TM PF11351.8 KOS21929.1 - 0.16 12.5 0.0 0.31 11.6 0.0 1.4 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release JmjC PF02373.22 KOS21930.1 - 2.7e-38 130.9 0.2 5.7e-38 129.8 0.2 1.6 1 0 0 1 1 1 1 JmjC domain, hydroxylase zf-HC5HC2H_2 PF13832.6 KOS21930.1 - 2.7e-20 72.5 3.4 5.4e-20 71.6 3.4 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 KOS21930.1 - 7.8e-20 70.9 3.9 7.8e-20 70.9 3.9 1.9 2 0 0 2 2 2 1 PHD-like zinc-binding domain JmjN PF02375.17 KOS21930.1 - 3.7e-13 49.2 0.7 1.2e-12 47.6 0.4 2.0 2 0 0 2 2 2 1 jmjN domain RXT2_N PF08595.11 KOS21930.1 - 0.00037 20.6 8.8 0.0056 16.7 1.5 2.8 2 0 0 2 2 2 2 RXT2-like, N-terminal eIF-3_zeta PF05091.12 KOS21931.1 - 0.025 13.6 13.5 0.042 12.8 13.5 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 KOS21931.1 - 0.7 8.1 46.9 0.031 12.5 40.3 1.8 1 1 1 2 2 2 0 Topoisomerase II-associated protein PAT1 Baculo_PP31 PF05311.11 KOS21931.1 - 1.8 8.0 12.2 0.056 12.9 5.9 1.7 2 0 0 2 2 2 0 Baculovirus 33KDa late protein (PP31) TERB2 PF15101.6 KOS21931.1 - 4 7.4 23.1 4.1 7.4 21.1 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 OATP PF03137.20 KOS21931.1 - 7.1 4.8 5.6 9.3 4.4 5.6 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF966 PF06136.13 KOS21931.1 - 9.4 5.8 22.3 15 5.2 22.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Shugoshin_N PF07558.11 KOS21932.1 - 5.2e-14 51.8 6.1 1.4e-13 50.4 6.1 1.8 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region DASH_Dad2 PF08654.10 KOS21933.1 - 1.4e-25 89.6 0.2 1.6e-25 89.4 0.2 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 SpoOE-like PF09388.10 KOS21933.1 - 0.0098 15.8 0.0 0.034 14.1 0.1 1.8 2 0 0 2 2 2 1 Spo0E like sporulation regulatory protein CK2S PF15011.6 KOS21933.1 - 0.039 13.8 0.1 0.046 13.6 0.1 1.0 1 0 0 1 1 1 0 Casein Kinase 2 substrate DASH_Duo1 PF08651.10 KOS21933.1 - 0.045 13.5 0.0 0.059 13.2 0.0 1.1 1 0 0 1 1 1 0 DASH complex subunit Duo1 Seryl_tRNA_N PF02403.22 KOS21933.1 - 0.06 13.6 0.1 0.074 13.3 0.1 1.2 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain NUC173 PF08161.12 KOS21934.1 - 4.9e-79 264.7 1.3 2.3e-77 259.3 0.0 3.5 4 0 0 4 4 4 1 NUC173 domain HEAT PF02985.22 KOS21934.1 - 0.00023 21.1 0.3 0.67 10.4 0.1 3.6 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 KOS21934.1 - 0.00098 19.5 1.3 2.1 8.8 0.2 3.9 3 0 0 3 3 3 2 HEAT repeats DUF2189 PF09955.9 KOS21934.1 - 0.051 13.8 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2189) BUD22 PF09073.10 KOS21934.1 - 0.85 8.9 13.7 0.18 11.1 9.7 1.9 2 0 0 2 2 2 0 BUD22 Metallophos_2 PF12850.7 KOS21935.1 - 6.8e-14 52.4 0.0 8.7e-14 52.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 KOS21935.1 - 0.0025 18.3 0.0 0.049 14.1 0.0 2.2 1 1 1 2 2 2 1 Calcineurin-like phosphoesterase HA2 PF04408.23 KOS21937.1 - 6.1e-17 61.9 0.1 1.5e-16 60.6 0.1 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 KOS21937.1 - 5.2e-15 55.6 0.0 1.2e-14 54.4 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 KOS21937.1 - 9.6e-13 48.4 0.0 2.4e-12 47.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 KOS21937.1 - 0.00013 22.3 0.0 0.0004 20.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 KOS21937.1 - 0.00042 20.1 0.3 0.0011 18.7 0.3 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_30 PF13604.6 KOS21937.1 - 0.00067 19.4 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS21937.1 - 0.0031 17.8 0.0 0.0077 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOS21937.1 - 0.03 13.4 0.0 0.072 12.1 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.19 KOS21937.1 - 0.062 12.9 0.1 0.83 9.2 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_23 PF13476.6 KOS21937.1 - 0.069 13.6 0.2 0.14 12.7 0.2 1.6 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 KOS21937.1 - 0.078 12.2 0.0 1.8 7.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_14 PF13173.6 KOS21937.1 - 0.13 12.3 0.2 8.8 6.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain COesterase PF00135.28 KOS21938.1 - 1e-58 199.5 0.0 1.3e-58 199.1 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 KOS21938.1 - 1.9e-05 24.6 3.3 0.024 14.5 0.2 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold SKG6 PF08693.10 KOS21939.1 - 2.2e-05 23.8 0.2 2.2e-05 23.8 0.2 3.0 3 0 0 3 3 3 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 KOS21939.1 - 0.02 14.8 0.0 0.02 14.8 0.0 3.3 2 1 1 3 3 3 0 TMEM154 protein family DUF4381 PF14316.6 KOS21939.1 - 0.18 12.0 0.1 0.34 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Mid2 PF04478.12 KOS21939.1 - 1.4 8.7 7.5 1.9 8.3 0.0 3.3 3 0 0 3 3 3 0 Mid2 like cell wall stress sensor Ribosomal_L13 PF00572.18 KOS21940.1 - 5.6e-12 46.0 0.2 6.4e-10 39.4 0.0 2.5 2 1 0 2 2 2 1 Ribosomal protein L13 Gemini_AL1 PF00799.20 KOS21940.1 - 0.048 14.0 0.0 0.085 13.2 0.0 1.3 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain TPR_2 PF07719.17 KOS21941.1 - 1.8e-07 30.7 6.7 0.00019 21.3 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS21941.1 - 0.00034 21.1 0.0 0.0055 17.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS21941.1 - 0.00048 20.4 4.3 0.0055 17.0 0.1 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS21941.1 - 0.00089 19.0 2.6 0.1 12.5 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_8 PF13181.6 KOS21941.1 - 0.0018 18.3 0.1 0.016 15.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 KOS21941.1 - 0.0027 18.3 7.9 0.0075 16.9 0.3 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_4 PF07721.14 KOS21941.1 - 0.017 15.7 3.9 0.19 12.5 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 KOS21941.1 - 0.025 14.0 1.0 0.3 10.4 0.5 2.1 2 0 0 2 2 2 0 MalT-like TPR region TPR_14 PF13428.6 KOS21941.1 - 0.052 14.4 0.1 0.052 14.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Adap_comp_sub PF00928.21 KOS21944.1 - 1.1e-74 251.1 0.0 1.5e-74 250.7 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 KOS21944.1 - 4.9e-05 23.3 0.3 8.7e-05 22.5 0.3 1.4 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Glyco_hydro_18 PF00704.28 KOS21945.1 - 1.5e-13 51.2 0.2 4.9e-13 49.5 0.2 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 SF1-HH PF16275.5 KOS21946.1 - 1.6e-44 150.8 0.7 1.6e-44 150.8 0.7 2.1 1 1 1 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 KOS21946.1 - 1.4e-08 34.5 0.1 2.8e-08 33.5 0.1 1.6 1 0 0 1 1 1 1 KH domain MULE PF10551.9 KOS21947.1 - 6.2e-15 55.4 0.1 1.9e-14 53.9 0.0 1.9 2 0 0 2 2 2 1 MULE transposase domain FAR1 PF03101.15 KOS21947.1 - 5.9e-06 26.9 0.2 1.3e-05 25.8 0.2 1.6 1 0 0 1 1 1 1 FAR1 DNA-binding domain Glutaredoxin PF00462.24 KOS21948.1 - 1.5e-20 73.1 0.0 2.2e-20 72.6 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_2 PF13098.6 KOS21948.1 - 5.1e-05 23.7 0.1 7.7e-05 23.1 0.1 1.4 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_4 PF13462.6 KOS21948.1 - 0.0019 18.4 0.2 0.34 11.1 0.2 2.1 1 1 1 2 2 2 2 Thioredoxin GST_N_3 PF13417.6 KOS21948.1 - 0.0024 18.3 0.0 0.0029 18.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF836 PF05768.14 KOS21948.1 - 0.015 15.7 0.0 0.018 15.4 0.0 1.3 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DSBA PF01323.20 KOS21948.1 - 0.015 15.1 0.2 0.45 10.3 0.1 2.0 1 1 1 2 2 2 0 DSBA-like thioredoxin domain DUF953 PF06110.11 KOS21948.1 - 0.02 14.5 0.2 0.1 12.2 0.1 1.9 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF953) Thioredoxin PF00085.20 KOS21948.1 - 0.021 14.8 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Plavaka PF18759.1 KOS21948.1 - 0.066 12.4 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Plavaka transposase Redoxin PF08534.10 KOS21948.1 - 0.093 12.4 0.4 0.15 11.8 0.4 1.3 1 1 0 1 1 1 0 Redoxin BAG PF02179.16 KOS21949.1 - 5.8e-20 71.5 0.9 6.3e-20 71.4 0.0 1.5 2 0 0 2 2 2 1 BAG domain ubiquitin PF00240.23 KOS21949.1 - 1.1e-05 25.0 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_5 PF18037.1 KOS21949.1 - 0.02 15.3 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-like domain Rad60-SLD PF11976.8 KOS21949.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 KOS21949.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DUF2407 PF10302.9 KOS21949.1 - 0.2 12.2 0.6 0.44 11.1 0.6 1.5 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain Abhydrolase_6 PF12697.7 KOS21951.1 - 7.7e-05 23.4 1.6 7.7e-05 23.4 1.6 2.2 1 1 1 2 2 2 1 Alpha/beta hydrolase family PGAP1 PF07819.13 KOS21951.1 - 0.00031 20.6 0.0 0.00054 19.8 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 KOS21951.1 - 0.0035 16.9 0.0 0.0055 16.2 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Hydrolase_4 PF12146.8 KOS21951.1 - 0.0058 15.9 0.6 0.021 14.1 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 KOS21951.1 - 0.086 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Asp PF00026.23 KOS21952.1 - 8.6e-57 192.9 0.0 1.1e-56 192.6 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS21952.1 - 2.1e-10 41.1 1.3 3.1e-09 37.3 1.3 2.3 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 KOS21952.1 - 6.1e-06 26.8 1.1 0.37 11.5 0.1 3.9 4 0 0 4 4 4 2 Aspartyl protease gag-asp_proteas PF13975.6 KOS21952.1 - 0.00022 21.7 0.1 3.6 8.2 0.0 3.9 4 0 0 4 4 4 2 gag-polyprotein putative aspartyl protease Abhydrolase_3 PF07859.13 KOS21953.1 - 1.7e-21 77.0 0.3 1.3e-20 74.2 0.3 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOS21953.1 - 1.1e-07 31.1 0.0 2.1e-07 30.1 0.0 1.5 1 1 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 KOS21953.1 - 0.019 15.6 0.7 0.026 15.1 0.7 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Methyltransf_25 PF13649.6 KOS21954.1 - 1.6e-13 51.2 0.0 3.3e-13 50.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS21954.1 - 6.2e-09 36.4 0.0 1.2e-08 35.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS21954.1 - 1.3e-08 34.9 0.0 2e-08 34.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS21954.1 - 2.4e-07 30.7 0.0 3.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS21954.1 - 1.3e-05 25.9 0.0 2.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS21954.1 - 0.11 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOS21954.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Complex1_LYR PF05347.15 KOS21955.1 - 2.3e-06 27.5 0.7 2.7e-06 27.3 0.7 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOS21955.1 - 0.00015 22.4 0.3 0.00018 22.2 0.3 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Ras PF00071.22 KOS21956.1 - 3e-50 170.0 0.0 3.6e-50 169.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS21956.1 - 1.7e-20 73.4 0.0 2.7e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS21956.1 - 5.9e-06 25.9 0.0 7.8e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS21956.1 - 0.004 16.7 0.1 0.009 15.6 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 KOS21956.1 - 0.015 15.2 0.0 0.091 12.7 0.0 2.0 2 1 0 2 2 2 0 RsgA GTPase Flocculin_t3 PF13928.6 KOS21957.1 - 0.0082 16.6 13.1 0.0082 16.6 13.1 6.1 4 2 2 6 6 6 3 Flocculin type 3 repeat bVLRF1 PF18826.1 KOS21958.1 - 2.6e-63 212.4 0.2 4.2e-63 211.7 0.2 1.3 1 0 0 1 1 1 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 KOS21958.1 - 5.7e-06 26.5 0.0 1.5e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Git3 PF11710.8 KOS21959.1 - 1.3e-20 74.1 9.3 2.8e-20 73.0 9.3 1.5 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 KOS21959.1 - 1.1e-08 34.8 5.2 1.6e-08 34.2 5.2 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 KOS21959.1 - 0.00036 20.5 0.2 0.0036 17.3 0.0 2.6 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term Dicty_CAR PF05462.11 KOS21959.1 - 0.012 14.8 11.8 0.026 13.6 11.6 1.6 1 1 0 1 1 1 0 Slime mold cyclic AMP receptor Mpv17_PMP22 PF04117.12 KOS21960.1 - 7.1e-12 45.4 0.4 1.4e-11 44.4 0.4 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family MFS_1 PF07690.16 KOS21962.1 - 7.9e-32 110.5 29.6 7.9e-32 110.5 29.6 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily NmrA PF05368.13 KOS21963.1 - 3e-49 167.7 2.8 3.9e-49 167.3 2.8 1.0 1 0 0 1 1 1 1 NmrA-like family NAD_binding_10 PF13460.6 KOS21963.1 - 3.5e-11 43.3 10.8 6.1e-11 42.6 9.2 1.9 1 1 0 2 2 2 1 NAD(P)H-binding Fasciclin PF02469.22 KOS21964.1 - 6.9e-42 142.7 0.0 1.1e-22 80.6 0.0 2.2 2 0 0 2 2 2 2 Fasciclin domain Amidohydro_2 PF04909.14 KOS21965.1 - 1.5e-33 116.8 0.9 2.2e-33 116.3 0.9 1.2 1 0 0 1 1 1 1 Amidohydrolase DUF2407_C PF13373.6 KOS21965.1 - 0.16 12.1 0.0 0.37 11.0 0.0 1.5 2 0 0 2 2 2 0 DUF2407 C-terminal domain Flavoprotein PF02441.19 KOS21966.1 - 5.4e-41 140.0 0.0 1.8e-40 138.3 0.0 1.7 1 1 0 1 1 1 1 Flavoprotein dCMP_cyt_deam_1 PF00383.23 KOS21968.1 - 8.2e-14 51.3 0.0 1.1e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOS21968.1 - 4.3e-07 29.8 0.0 5.1e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 KOS21968.1 - 0.00043 20.4 0.0 0.00066 19.8 0.0 1.2 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 OTT_1508_deam PF14441.6 KOS21968.1 - 0.0025 17.8 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 OTT_1508-like deaminase NAD1 PF18778.1 KOS21968.1 - 0.007 16.5 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 KOS21968.1 - 0.008 16.3 4.2 0.93 9.6 0.0 2.3 1 1 1 2 2 2 2 Bd3614-like deaminase APOBEC2 PF18772.1 KOS21968.1 - 0.021 14.9 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 APOBEC2 DUF4716 PF15837.5 KOS21968.1 - 0.025 14.6 1.0 0.064 13.3 1.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4716) NAD2 PF18782.1 KOS21968.1 - 0.038 14.1 0.0 0.053 13.6 0.0 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 2 DUF2958 PF11171.8 KOS21968.1 - 0.07 13.4 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2958) Dioxygenase_C PF00775.21 KOS21969.1 - 9.7e-53 178.3 0.0 1.3e-52 177.9 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 KOS21969.1 - 3.1e-24 84.6 0.1 5.4e-24 83.8 0.1 1.3 1 0 0 1 1 1 1 Catechol dioxygenase N terminus CarboxypepD_reg PF13620.6 KOS21969.1 - 3e-06 27.4 0.0 1.7e-05 25.0 0.0 2.1 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain DUF4198 PF10670.9 KOS21969.1 - 0.18 12.1 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4198) FAD_binding_3 PF01494.19 KOS21970.1 - 6e-11 42.2 0.1 6.3e-05 22.4 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 KOS21970.1 - 2e-10 40.7 0.6 6.5e-10 39.1 0.3 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 KOS21970.1 - 1.4e-07 31.5 0.1 2e-07 30.9 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS21970.1 - 2.6e-06 26.9 0.1 4e-06 26.3 0.1 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 KOS21970.1 - 3.1e-06 26.8 0.0 3.5e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS21970.1 - 5e-06 25.9 0.8 6.7e-06 25.4 0.8 1.2 1 0 0 1 1 1 1 FAD binding domain Amino_oxidase PF01593.24 KOS21970.1 - 0.0002 20.8 0.0 0.0036 16.7 0.0 2.1 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase GIDA PF01134.22 KOS21970.1 - 0.00021 20.5 1.0 0.00028 20.1 1.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox PF00070.27 KOS21970.1 - 0.002 18.6 1.1 0.0046 17.5 1.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 KOS21970.1 - 0.005 15.6 1.2 0.007 15.1 1.2 1.1 1 0 0 1 1 1 1 HI0933-like protein Lycopene_cycl PF05834.12 KOS21970.1 - 0.0072 15.4 0.1 0.0095 15.0 0.1 1.1 1 0 0 1 1 1 1 Lycopene cyclase protein Rossmann-like PF10727.9 KOS21970.1 - 0.015 15.2 0.5 0.027 14.3 0.5 1.4 1 0 0 1 1 1 0 Rossmann-like domain Trp_halogenase PF04820.14 KOS21970.1 - 0.027 13.3 1.2 0.038 12.9 1.2 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox_3 PF13738.6 KOS21970.1 - 0.048 12.9 1.2 0.072 12.3 1.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS21970.1 - 0.1 11.9 0.9 0.17 11.1 0.9 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MCRA PF06100.11 KOS21970.1 - 0.18 10.5 0.2 0.34 9.7 0.2 1.3 1 0 0 1 1 1 0 MCRA family MFS_1 PF07690.16 KOS21971.1 - 1.7e-24 86.4 31.3 1.5e-23 83.3 30.6 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Phage_stabilise PF11134.8 KOS21972.1 - 0.13 11.1 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Phage stabilisation protein Myb_DNA-bind_3 PF12776.7 KOS21973.1 - 8e-25 87.7 0.3 9.3e-25 87.4 0.3 1.1 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 KOS21973.1 - 0.092 13.4 0.1 0.11 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF573 adh_short PF00106.25 KOS21974.1 - 6.3e-36 123.7 0.0 9.5e-36 123.1 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS21974.1 - 1.1e-25 90.6 0.0 1.4e-25 90.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS21974.1 - 1.4e-06 28.4 0.1 4.7e-06 26.6 0.0 1.9 2 1 0 2 2 2 1 KR domain 3HCDH_N PF02737.18 KOS21974.1 - 0.0049 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 KOS21974.1 - 0.04 14.2 0.3 1.4 9.2 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_31 PF13847.6 KOS21974.1 - 0.058 13.2 0.0 0.13 12.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain Epimerase PF01370.21 KOS21974.1 - 0.074 12.5 0.1 0.1 12.1 0.1 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF1776 PF08643.10 KOS21974.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) ADH_zinc_N PF00107.26 KOS21974.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Glycos_transf_1 PF00534.20 KOS21975.1 - 1.3e-31 109.5 0.0 2e-31 108.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOS21975.1 - 4.1e-28 98.5 0.2 6.5e-28 97.8 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOS21975.1 - 6.8e-17 62.4 3.7 6.8e-17 62.4 3.7 2.3 1 1 1 2 2 2 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 KOS21975.1 - 5.3e-15 55.8 1.2 2.9e-14 53.4 0.3 2.2 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.6 KOS21975.1 - 1.6e-09 38.0 0.0 3.6e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 MHB PF16525.5 KOS21975.1 - 0.086 13.1 0.0 1.1 9.6 0.0 2.6 2 0 0 2 2 2 0 Haemophore, haem-binding UDPG_MGDP_dh_N PF03721.14 KOS21976.1 - 1.2e-47 161.9 0.0 3.7e-30 104.9 0.0 2.3 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 KOS21976.1 - 7.1e-32 109.5 0.0 1.4e-31 108.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 KOS21976.1 - 1.6e-22 79.9 0.0 3.1e-17 62.9 0.0 3.3 3 0 0 3 3 3 2 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Sacchrp_dh_NADP PF03435.18 KOS21976.1 - 0.023 14.9 0.0 0.052 13.8 0.0 1.6 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 KOS21976.1 - 0.039 14.1 0.0 0.98 9.6 0.0 2.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase 4HBT_2 PF13279.6 KOS21977.1 - 2.6e-15 57.0 0.0 4.1e-15 56.3 0.0 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily NAD_binding_10 PF13460.6 KOS21978.1 - 0.00084 19.3 0.8 0.013 15.4 0.8 2.2 1 1 0 1 1 1 1 NAD(P)H-binding FmdA_AmdA PF03069.15 KOS21979.1 - 1e-142 475.4 0.0 1.2e-142 475.2 0.0 1.0 1 0 0 1 1 1 1 Acetamidase/Formamidase family CoA_binding PF02629.19 KOS21981.1 - 1.9e-27 95.7 1.1 1.9e-27 95.7 1.1 2.2 2 0 0 2 2 2 1 CoA binding domain Ligase_CoA PF00549.19 KOS21981.1 - 4e-23 81.9 0.7 7.1e-23 81.1 0.7 1.4 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 KOS21981.1 - 4.5e-10 39.5 0.1 7.5e-10 38.7 0.1 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 KOS21981.1 - 0.00016 22.2 0.1 0.0005 20.6 0.1 1.8 2 0 0 2 2 2 1 CoA binding domain UPF0492 PF15744.5 KOS21981.1 - 0.11 11.7 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 Radical_SAM_C PF16199.5 KOS21982.1 - 5.5e-33 112.8 0.0 1e-32 112.0 0.0 1.5 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 KOS21982.1 - 3e-17 63.5 0.1 1.7e-16 61.1 0.0 2.2 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 KOS21982.1 - 1.4e-09 38.2 0.1 2.6e-09 37.3 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS21982.1 - 9.9e-06 25.5 0.0 2.1e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS21982.1 - 0.042 14.3 0.0 0.096 13.1 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Adaptin_N PF01602.20 KOS21983.1 - 4.2e-116 388.6 0.1 5.7e-116 388.1 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 KOS21983.1 - 4.2e-55 186.1 3.4 9.4e-55 184.9 3.4 1.6 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 KOS21983.1 - 8.1e-35 119.4 0.1 2.1e-34 118.1 0.1 1.8 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 KOS21983.1 - 1.3e-18 67.2 0.8 9.7e-12 45.1 0.0 5.2 2 1 3 5 5 5 3 HEAT repeats Cnd1 PF12717.7 KOS21983.1 - 8.9e-08 32.3 8.6 0.028 14.4 0.1 4.7 4 1 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 KOS21983.1 - 0.0015 19.1 0.1 7.1 7.6 0.0 4.1 3 0 0 3 3 3 2 PBS lyase HEAT-like repeat Arm PF00514.23 KOS21983.1 - 0.0094 16.0 0.0 2 8.6 0.0 4.2 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 KOS21983.1 - 0.025 14.1 3.4 0.11 12.0 0.1 3.1 4 0 0 4 4 4 0 CLASP N terminal HEAT PF02985.22 KOS21983.1 - 0.088 13.1 10.3 0.62 10.5 0.2 5.6 6 0 0 6 6 6 0 HEAT repeat DUF5010 PF16402.5 KOS21983.1 - 0.17 10.7 0.0 0.38 9.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5010) FMO-like PF00743.19 KOS21985.1 - 1.3e-13 50.3 0.1 2e-13 49.6 0.1 1.4 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 KOS21985.1 - 5.8e-08 32.3 0.0 0.00022 20.5 0.0 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 KOS21985.1 - 8.4e-07 29.1 0.0 2e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 KOS21985.1 - 0.0037 16.6 0.0 0.15 11.3 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Mqo PF06039.15 KOS21985.1 - 0.077 11.5 0.0 0.32 9.5 0.0 1.8 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) Shikimate_DH PF01488.20 KOS21985.1 - 0.2 11.7 0.0 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ATP12 PF07542.11 KOS21986.1 - 4.2e-41 140.1 0.1 1.4e-40 138.4 0.1 1.8 2 0 0 2 2 2 1 ATP12 chaperone protein UnbV_ASPIC PF07593.12 KOS21986.1 - 0.088 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 ASPIC and UnbV Exo_endo_phos PF03372.23 KOS21987.1 - 9.6e-20 71.1 0.4 1.1e-18 67.6 0.4 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_4 PF12799.7 KOS21987.1 - 1.3e-07 31.8 5.1 0.0082 16.5 1.9 2.5 1 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS21987.1 - 4.4e-06 26.3 7.0 0.00017 21.3 0.3 2.4 2 0 0 2 2 2 2 Leucine rich repeat adh_short PF00106.25 KOS21988.1 - 2.1e-19 69.8 0.0 2.9e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS21988.1 - 3.2e-12 46.5 0.0 4.8e-12 45.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS21988.1 - 1.8e-08 34.5 0.2 6.3e-08 32.7 0.2 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS21988.1 - 3.4e-05 23.4 0.0 4.4e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOS21988.1 - 0.00018 20.6 0.0 0.00022 20.3 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 KOS21988.1 - 0.017 15.4 0.0 0.031 14.5 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_10 PF13460.6 KOS21988.1 - 0.043 13.7 0.1 0.055 13.3 0.1 1.2 1 0 0 1 1 1 0 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KOS21988.1 - 0.078 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Mito_carr PF00153.27 KOS21989.1 - 1.9e-15 56.6 0.8 5.2e-09 35.9 0.0 3.3 2 1 0 2 2 2 2 Mitochondrial carrier protein WW PF00397.26 KOS21992.1 - 1.4e-09 37.8 0.2 3e-09 36.8 0.2 1.6 1 0 0 1 1 1 1 WW domain Peptidase_M16 PF00675.20 KOS21993.1 - 5.3e-18 65.4 0.0 1.2e-17 64.3 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 KOS21993.1 - 2.2e-12 47.4 0.0 3.8e-12 46.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain LsmAD PF06741.13 KOS21994.1 - 7.6e-27 93.7 2.9 7.6e-27 93.7 2.9 2.6 2 0 0 2 2 2 1 LsmAD domain SUIM_assoc PF16619.5 KOS21994.1 - 0.01 15.9 5.6 0.01 15.9 5.6 4.7 4 1 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 Mito_carr PF00153.27 KOS21995.1 - 9.3e-30 102.4 0.4 4.2e-15 55.4 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein RNA_pol_Rpc82 PF05645.13 KOS21996.1 - 8e-53 179.8 0.0 1e-51 176.2 0.0 2.4 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 KOS21996.1 - 7.6e-13 48.4 0.6 6.1e-11 42.3 0.1 3.2 3 0 0 3 3 3 1 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 KOS21996.1 - 0.0011 18.8 0.1 0.18 11.7 0.0 2.8 2 0 0 2 2 2 2 TFIIE alpha subunit MutS_II PF05188.17 KOS21996.1 - 0.14 12.5 0.3 0.37 11.1 0.3 1.7 1 0 0 1 1 1 0 MutS domain II Cytochrom_B562 PF07361.11 KOS21998.1 - 0.0082 16.8 0.7 0.0082 16.8 0.7 7.4 6 3 2 8 8 8 2 Cytochrome b562 HALZ PF02183.18 KOS21998.1 - 4.1 7.7 10.1 2.2 8.6 0.3 4.2 4 0 0 4 4 4 0 Homeobox associated leucine zipper Pga1 PF10333.9 KOS21999.1 - 0.0003 20.7 0.0 0.00072 19.5 0.0 1.5 1 1 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Tubulin PF00091.25 KOS22000.1 - 5.9e-65 219.2 0.0 8.3e-65 218.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOS22000.1 - 7e-48 161.9 0.1 1.1e-47 161.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 KOS22000.1 - 0.00042 20.0 0.0 0.0009 19.0 0.0 1.6 1 0 0 1 1 1 1 Tubulin domain Brix PF04427.18 KOS22001.1 - 7.7e-31 107.7 0.1 9.7e-31 107.4 0.1 1.1 1 0 0 1 1 1 1 Brix domain Peptidase_M14 PF00246.24 KOS22002.1 - 1.3e-34 120.4 0.0 1.6e-34 120.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase ATG22 PF11700.8 KOS22003.1 - 1.1e-192 640.9 11.3 1.4e-192 640.6 11.3 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like UPF1_Zn_bind PF09416.10 KOS22004.1 - 7.4e-69 230.6 0.9 7.4e-69 230.6 0.9 2.0 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 KOS22004.1 - 1.9e-60 203.9 0.0 5.8e-60 202.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 KOS22004.1 - 2.7e-53 181.4 3.0 3.8e-31 108.8 0.5 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 KOS22004.1 - 3.1e-31 107.5 0.0 6.2e-31 106.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 KOS22004.1 - 2.1e-14 53.7 0.4 6.2e-13 48.9 0.4 2.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS22004.1 - 5.3e-10 39.8 0.1 2e-09 37.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 KOS22004.1 - 3.5e-06 27.1 0.0 7.5e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 KOS22004.1 - 6.1e-05 22.9 0.2 0.16 11.7 0.0 2.8 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase DEAD PF00270.29 KOS22004.1 - 0.0011 18.8 0.2 0.0021 17.8 0.1 1.6 1 1 0 1 1 1 1 DEAD/DEAH box helicase Helicase_RecD PF05127.14 KOS22004.1 - 0.0012 18.7 0.1 0.0024 17.7 0.1 1.5 1 0 0 1 1 1 1 Helicase DUF2075 PF09848.9 KOS22004.1 - 0.0015 17.8 0.9 0.02 14.2 0.1 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_10 PF12846.7 KOS22004.1 - 0.0034 16.4 0.0 0.0056 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain ATPase PF06745.13 KOS22004.1 - 0.0049 16.3 0.0 0.03 13.7 0.0 2.0 2 0 0 2 2 2 1 KaiC UvrD-helicase PF00580.21 KOS22004.1 - 0.0068 16.0 0.0 0.12 11.9 0.0 2.2 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain PIF1 PF05970.14 KOS22004.1 - 0.015 14.5 0.5 2.2 7.4 0.1 2.3 1 1 0 2 2 2 0 PIF1-like helicase Ribosomal_S13_N PF08069.12 KOS22004.1 - 0.022 14.8 0.0 0.061 13.4 0.0 1.7 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain SelK_SelG PF10961.8 KOS22006.1 - 0.0069 17.0 0.1 0.01 16.4 0.1 1.3 1 0 0 1 1 1 1 Selenoprotein SelK_SelG SPT_ssu-like PF11779.8 KOS22006.1 - 0.14 11.8 3.3 0.33 10.6 1.1 2.0 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like Fer4 PF00037.27 KOS22007.1 - 1.8e-13 49.7 16.5 6.2e-08 32.1 3.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 KOS22007.1 - 1e-12 48.4 10.2 1.6e-12 47.8 10.2 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 KOS22007.1 - 3.1e-10 40.8 7.5 7.6e-05 23.6 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_21 PF14697.6 KOS22007.1 - 2.3e-09 37.2 31.7 6.9e-06 26.1 12.3 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_10 PF13237.6 KOS22007.1 - 1.7e-08 34.4 21.3 3e-06 27.3 12.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 KOS22007.1 - 4.3e-08 33.2 9.9 9e-08 32.2 10.0 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 KOS22007.1 - 3.6e-07 30.5 18.7 0.00011 22.5 10.9 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 KOS22007.1 - 1.6e-06 27.9 17.1 0.0004 20.3 5.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 KOS22007.1 - 5e-06 26.3 11.8 0.01 15.9 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 KOS22007.1 - 9.4e-06 25.7 11.4 0.0003 21.1 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.6 KOS22007.1 - 0.0003 21.3 11.4 0.039 14.5 12.4 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 KOS22007.1 - 0.0062 16.7 5.4 0.6 10.4 0.4 2.2 1 1 1 2 2 2 2 c-SKI Smad4 binding domain ETF_QO PF05187.13 KOS22007.1 - 0.05 13.7 5.2 0.21 11.8 0.4 2.2 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_18 PF13746.6 KOS22007.1 - 0.075 13.2 8.8 1.2 9.3 1.6 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 KOS22007.1 - 0.086 13.4 15.2 0.76 10.4 4.3 2.6 2 1 1 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 KOS22007.1 - 0.25 12.4 15.5 0.43 11.6 3.3 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_22 PF17179.4 KOS22007.1 - 0.93 10.4 12.0 2.9 8.8 1.8 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain F_actin_cap_B PF01115.17 KOS22009.1 - 3.3e-104 347.7 0.0 3.7e-104 347.5 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit BAH PF01426.18 KOS22010.1 - 0.0012 18.7 0.0 0.0021 17.9 0.0 1.4 1 0 0 1 1 1 1 BAH domain NFACT-C PF11923.8 KOS22011.1 - 8.7e-40 134.9 0.3 8.7e-40 134.9 0.3 3.9 5 0 0 5 5 5 1 NFACT protein C-terminal domain FbpA PF05833.11 KOS22011.1 - 1.4e-33 116.4 6.6 1.4e-33 116.4 6.6 2.2 2 0 0 2 2 2 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 KOS22011.1 - 3.4e-27 95.2 0.0 7.4e-27 94.1 0.0 1.6 1 0 0 1 1 1 1 NFACT protein RNA binding domain B12-binding_2 PF02607.17 KOS22011.1 - 6.1 7.4 7.5 4.1 7.9 3.0 2.8 2 1 0 2 2 2 0 B12 binding domain Prenyltransf PF01255.19 KOS22012.1 - 5.5e-06 26.1 0.0 3.5e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Putative undecaprenyl diphosphate synthase Sec10 PF07393.11 KOS22013.1 - 1.6e-217 724.3 6.8 1.9e-217 724.1 6.8 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 MRP-S31 PF15433.6 KOS22013.1 - 0.028 14.1 0.1 0.059 13.0 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 HORMA PF02301.18 KOS22013.1 - 0.039 13.5 0.3 0.34 10.4 0.1 2.4 2 0 0 2 2 2 0 HORMA domain PG_isomerase_N PF18353.1 KOS22013.1 - 0.1 13.0 0.0 0.66 10.4 0.0 2.2 2 0 0 2 2 2 0 Phosphoglucose isomerase N-terminal domain PEX-1N PF09262.11 KOS22013.1 - 0.3 11.5 1.1 11 6.5 0.0 3.1 3 0 0 3 3 3 0 Peroxisome biogenesis factor 1, N-terminal Cep57_MT_bd PF06657.13 KOS22013.1 - 0.7 10.4 3.0 1 9.9 0.2 2.8 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Dus PF01207.17 KOS22014.1 - 3.5e-07 29.6 0.0 0.0036 16.4 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) Dus PF01207.17 KOS22015.1 - 6.3e-26 91.2 0.0 9.1e-26 90.7 0.0 1.2 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) SOG2 PF10428.9 KOS22016.1 - 0.065 12.4 6.1 0.072 12.3 6.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FAA_hydrolase PF01557.18 KOS22017.1 - 1.2e-64 217.9 0.0 1.6e-64 217.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family DUF2948 PF11164.8 KOS22017.1 - 0.026 14.5 0.0 0.042 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2948) Complex1_LYR PF05347.15 KOS22018.1 - 4e-17 62.0 3.9 4.7e-17 61.8 3.9 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOS22018.1 - 5.1e-06 27.1 0.8 6e-06 26.9 0.8 1.1 1 0 0 1 1 1 1 Complex1_LYR-like PSI PF01437.25 KOS22019.1 - 0.14 12.7 13.5 0.22 12.1 13.5 1.4 1 0 0 1 1 1 0 Plexin repeat ThiS PF02597.20 KOS22020.1 - 1.5e-08 35.2 0.0 2e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 ThiS family Smg4_UPF3 PF03467.15 KOS22021.1 - 5.6e-35 120.9 0.6 5.8e-20 72.0 0.0 3.3 2 1 1 3 3 3 2 Smg-4/UPF3 family RRM_1 PF00076.22 KOS22021.1 - 8.8e-08 31.9 0.3 4.8e-06 26.3 0.0 2.7 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 KOS22021.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Metallophos PF00149.28 KOS22022.1 - 1.9e-32 113.5 0.0 2.8e-31 109.6 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Glyco_hydro_65N PF03636.15 KOS22022.1 - 0.019 14.6 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Met_10 PF02475.16 KOS22023.1 - 2.3e-06 27.5 0.0 4.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein CoA_binding_3 PF13727.6 KOS22023.1 - 0.03 14.3 0.2 0.064 13.3 0.2 1.5 1 0 0 1 1 1 0 CoA-binding domain MTS PF05175.14 KOS22023.1 - 0.11 12.0 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain EF-hand_6 PF13405.6 KOS22024.1 - 4e-09 35.7 0.2 0.0016 18.2 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 KOS22024.1 - 6.6e-06 26.5 0.0 1.6e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 KOS22024.1 - 0.00014 21.2 0.0 0.00094 18.6 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 KOS22024.1 - 0.00036 19.9 0.2 0.012 15.1 0.0 2.5 2 0 0 2 2 2 1 EF hand PepSY_2 PF13670.6 KOS22024.1 - 0.082 12.9 0.1 0.23 11.5 0.1 1.8 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain zf-TRM13_CCCH PF11722.8 KOS22025.1 - 0.099 12.4 16.2 10 6.0 0.6 5.4 5 1 0 5 5 5 0 CCCH zinc finger in TRM13 protein CENP-H PF05837.12 KOS22026.1 - 0.0011 19.3 4.5 0.029 14.8 0.6 2.3 2 0 0 2 2 2 1 Centromere protein H (CENP-H) Herpes_BLRF2 PF05812.12 KOS22026.1 - 0.013 15.6 0.7 0.42 10.8 0.0 2.5 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein YabA PF06156.13 KOS22026.1 - 0.013 16.1 5.1 0.18 12.5 2.1 2.7 1 1 1 2 2 2 0 Initiation control protein YabA bZIP_2 PF07716.15 KOS22026.1 - 0.018 15.1 9.0 0.49 10.5 8.8 2.9 2 0 0 2 2 2 0 Basic region leucine zipper TSC22 PF01166.18 KOS22026.1 - 0.019 15.2 4.2 1.1 9.6 2.2 2.9 3 0 0 3 3 3 0 TSC-22/dip/bun family ATG16 PF08614.11 KOS22026.1 - 0.024 14.9 10.6 0.081 13.1 10.3 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 KOS22026.1 - 0.035 14.5 11.2 0.042 14.3 2.4 3.1 2 1 0 2 2 2 0 Cell division protein ZapB ADIP PF11559.8 KOS22026.1 - 0.038 14.1 2.1 0.038 14.1 2.1 2.2 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding SNAPc19 PF15497.6 KOS22026.1 - 0.039 14.4 0.4 4.6 7.8 0.9 2.6 3 0 0 3 3 3 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Shugoshin_N PF07558.11 KOS22026.1 - 0.05 13.5 2.2 0.95 9.4 1.3 2.6 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region KASH_CCD PF14662.6 KOS22026.1 - 0.073 12.9 10.3 7 6.4 10.2 2.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Leu_zip PF15294.6 KOS22026.1 - 0.081 12.4 6.2 0.031 13.8 2.2 2.0 1 1 0 2 2 2 0 Leucine zipper Jnk-SapK_ap_N PF09744.9 KOS22026.1 - 0.097 12.9 8.8 2.4 8.3 0.0 2.7 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Uso1_p115_C PF04871.13 KOS22026.1 - 0.099 13.0 5.5 0.2 12.1 2.5 2.1 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region GIT_CC PF16559.5 KOS22026.1 - 0.2 11.5 4.3 15 5.5 0.6 3.1 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor Cnn_1N PF07989.11 KOS22026.1 - 0.35 11.0 5.6 0.38 11.0 2.3 2.6 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 KOS22026.1 - 0.43 10.7 6.0 4.5 7.3 4.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 KOS22026.1 - 0.63 9.9 11.5 0.37 10.6 5.0 3.3 2 2 1 3 3 3 0 Septum formation initiator NUDE_C PF04880.13 KOS22026.1 - 0.94 9.9 9.9 0.75 10.2 8.1 1.7 1 1 1 2 2 2 0 NUDE protein, C-terminal conserved region TMF_TATA_bd PF12325.8 KOS22026.1 - 1.4 9.1 10.3 1.6 8.9 6.3 2.6 2 2 0 2 2 2 0 TATA element modulatory factor 1 TATA binding bZIP_1 PF00170.21 KOS22026.1 - 1.7 8.8 11.5 0.46 10.6 3.5 3.1 4 0 0 4 4 3 0 bZIP transcription factor DUF4407 PF14362.6 KOS22026.1 - 1.9 7.7 6.6 7.1 5.9 6.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.8 KOS22026.1 - 3.3 7.8 7.6 4.2 7.4 4.1 2.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 KOS22027.1 - 0.00052 20.5 9.8 0.00052 20.5 9.8 2.4 1 1 0 2 2 2 1 Apg6 coiled-coil region DUF3810 PF12725.7 KOS22027.1 - 1.4 8.2 4.4 3.4 6.9 4.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Prominin PF05478.11 KOS22027.1 - 1.8 6.4 4.4 2.4 6.0 4.4 1.1 1 0 0 1 1 1 0 Prominin CotJB PF12652.7 KOS22027.1 - 1.9 8.8 6.2 0.84 9.9 0.1 3.1 3 1 0 3 3 3 0 CotJB protein DUF3584 PF12128.8 KOS22027.1 - 2.6 5.4 32.1 4.1 4.8 32.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4746 PF15928.5 KOS22027.1 - 3.6 6.9 11.9 6.4 6.1 11.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TRF PF08558.10 KOS22029.1 - 1.4e-13 51.0 0.0 7e-12 45.5 0.0 2.2 1 1 0 1 1 1 1 Telomere repeat binding factor (TRF) Peptidase_S30 PF01577.16 KOS22030.1 - 0.02 14.5 2.5 0.025 14.2 2.5 1.1 1 0 0 1 1 1 0 Potyvirus P1 protease Aconitase PF00330.20 KOS22030.1 - 0.024 13.6 0.5 0.026 13.5 0.5 1.0 1 0 0 1 1 1 0 Aconitase family (aconitate hydratase) CPSF100_C PF13299.6 KOS22030.1 - 0.032 14.4 3.9 0.037 14.2 3.9 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ProQ_C PF17516.2 KOS22030.1 - 0.13 11.7 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 ProQ C-terminal domain Itfg2 PF15907.5 KOS22030.1 - 0.16 11.0 2.9 0.17 10.9 2.9 1.1 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 Macoilin PF09726.9 KOS22030.1 - 0.39 9.2 9.9 0.4 9.2 9.9 1.1 1 0 0 1 1 1 0 Macoilin family SSP160 PF06933.11 KOS22030.1 - 0.44 8.7 11.1 0.49 8.5 11.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Presenilin PF01080.17 KOS22030.1 - 2.1 7.0 9.4 2.4 6.8 9.4 1.0 1 0 0 1 1 1 0 Presenilin Pannexin_like PF12534.8 KOS22030.1 - 3.7 6.5 4.5 4.2 6.3 4.5 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Miga PF10265.9 KOS22030.1 - 3.7 6.4 8.5 4.4 6.2 8.5 1.1 1 0 0 1 1 1 0 Mitoguardin Pet20 PF08692.10 KOS22030.1 - 4.2 8.1 6.7 5.6 7.7 6.4 1.4 1 1 0 1 1 1 0 Mitochondrial protein Pet20 Choline_transpo PF04515.12 KOS22031.1 - 2.7e-84 283.2 20.8 2.7e-84 283.2 20.8 2.1 2 0 0 2 2 2 1 Plasma-membrane choline transporter zf-C2H2_2 PF12756.7 KOS22032.1 - 2.3e-34 117.8 14.2 9.5e-29 99.7 5.4 3.6 3 0 0 3 3 3 3 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 KOS22032.1 - 1.9e-07 31.2 7.6 5.5e-07 29.7 2.7 3.9 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS22032.1 - 2.2e-07 31.0 1.1 2.2e-07 31.0 1.1 3.3 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 KOS22032.1 - 0.016 16.0 21.6 0.47 11.4 0.2 5.7 6 0 0 6 6 6 0 C2H2-type zinc finger SnoaL_2 PF12680.7 KOS22032.1 - 0.06 14.0 0.2 0.8 10.4 0.1 2.6 2 1 0 2 2 2 0 SnoaL-like domain DUF629 PF04780.12 KOS22032.1 - 0.93 7.9 6.6 0.33 9.4 0.1 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF629) AZUL PF16558.5 KOS22033.1 - 2.9e-23 81.9 1.5 4.9e-23 81.1 1.5 1.4 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A Acetyltransf_1 PF00583.25 KOS22034.1 - 7.6e-07 29.4 0.0 9.8e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS22034.1 - 2.2e-06 27.6 0.0 3.4e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22034.1 - 1.7e-05 25.1 0.0 2.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS22034.1 - 0.14 12.3 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS22034.1 - 0.19 11.7 0.1 0.38 10.8 0.1 1.6 1 1 0 1 1 1 0 FR47-like protein Clathrin_H_link PF13838.6 KOS22035.1 - 0.095 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Clathrin-H-link Rax2 PF12768.7 KOS22035.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 Cortical protein marker for cell polarity SKG6 PF08693.10 KOS22035.1 - 8.4 5.9 11.3 21 4.6 11.3 1.7 1 1 0 1 1 1 0 Transmembrane alpha-helix domain Methyltransf_31 PF13847.6 KOS22036.1 - 4.9e-18 65.4 0.0 7.6e-18 64.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22036.1 - 8.7e-13 48.8 0.1 1.8e-12 47.8 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22036.1 - 5.8e-09 36.5 0.1 1.6e-08 35.1 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS22036.1 - 2e-08 34.2 0.0 2.7e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22036.1 - 1.4e-07 32.2 0.0 2.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 KOS22036.1 - 6.6e-07 29.0 0.0 1e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 KOS22036.1 - 1e-05 25.2 0.0 1.6e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KOS22036.1 - 1.4e-05 24.6 0.0 2.1e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 KOS22036.1 - 0.00039 19.8 0.0 0.00058 19.2 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 KOS22036.1 - 0.0035 17.3 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 KOS22036.1 - 0.005 16.6 0.0 0.0069 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 KOS22036.1 - 0.034 13.6 0.0 0.054 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MMR_HSR1 PF01926.23 KOS22037.1 - 8.1e-16 58.1 0.0 1.2e-15 57.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS22037.1 - 0.0001 22.3 0.1 0.015 15.2 0.0 2.7 3 1 0 3 3 3 1 RsgA GTPase Dynamin_N PF00350.23 KOS22037.1 - 0.00021 21.4 0.0 0.0049 16.9 0.0 2.3 2 0 0 2 2 2 1 Dynamin family FeoB_N PF02421.18 KOS22037.1 - 0.0018 17.8 0.0 0.07 12.7 0.0 2.2 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 KOS22037.1 - 0.0029 17.2 0.0 0.033 13.7 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 KOS22037.1 - 0.011 15.9 0.1 0.51 10.6 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 KOS22037.1 - 0.023 14.0 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Septin PF00735.18 KOS22037.1 - 0.032 13.5 0.0 0.075 12.3 0.0 1.6 1 1 0 1 1 1 0 Septin AAA_25 PF13481.6 KOS22037.1 - 0.033 13.8 0.0 0.33 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AIG1 PF04548.16 KOS22037.1 - 0.034 13.5 0.0 0.25 10.6 0.0 2.0 1 1 0 1 1 1 0 AIG1 family AAA_29 PF13555.6 KOS22037.1 - 0.05 13.4 0.0 0.27 11.0 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain TniB PF05621.11 KOS22037.1 - 0.13 11.6 0.0 0.29 10.5 0.0 1.4 1 1 0 1 1 1 0 Bacterial TniB protein HECT PF00632.25 KOS22038.1 - 2.6e-69 234.0 0.0 3.6e-69 233.6 0.0 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) 2OG-FeII_Oxy_2 PF13532.6 KOS22039.1 - 4.7e-32 111.8 0.0 1.4e-31 110.2 0.0 1.7 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CDC45 PF02724.14 KOS22039.1 - 0.28 9.4 0.6 0.39 8.9 0.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 KOS22039.1 - 0.75 10.2 6.9 1.4 9.4 6.9 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal adh_short PF00106.25 KOS22040.1 - 1.2e-32 113.0 0.0 1.7e-32 112.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS22040.1 - 1.1e-25 90.6 0.0 1.5e-25 90.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 KOS22040.1 - 0.016 14.6 0.0 0.022 14.2 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) AAA_16 PF13191.6 KOS22041.1 - 0.0082 16.5 0.0 0.08 13.3 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 KOS22041.1 - 0.012 15.4 0.1 0.031 14.0 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 KOS22041.1 - 0.024 14.9 0.1 0.11 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 KOS22041.1 - 0.032 14.2 0.2 0.15 12.0 0.0 2.3 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 KOS22041.1 - 0.038 13.7 0.0 0.094 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOS22041.1 - 0.043 14.3 0.0 0.11 13.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter RsgA_GTPase PF03193.16 KOS22041.1 - 0.048 13.6 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_18 PF13238.6 KOS22041.1 - 0.048 14.2 0.4 0.29 11.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOS22041.1 - 0.076 13.5 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain FliT PF05400.13 KOS22041.1 - 0.23 12.3 10.1 1.7 9.5 0.1 3.1 3 0 0 3 3 2 0 Flagellar protein FliT Sec7_N PF12783.7 KOS22041.1 - 0.3 11.0 3.8 2 8.3 0.1 3.1 2 1 1 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal COQ7 PF03232.13 KOS22043.1 - 6.1e-70 234.5 0.6 6.9e-70 234.3 0.6 1.0 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 Rubrerythrin PF02915.17 KOS22043.1 - 0.0011 19.3 0.0 0.003 17.9 0.0 1.8 2 0 0 2 2 2 1 Rubrerythrin PLDc PF00614.22 KOS22044.1 - 9.7e-17 60.4 0.4 1.6e-07 31.2 0.3 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 KOS22044.1 - 2.1e-12 47.1 0.0 1.6e-06 28.1 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PX PF00787.24 KOS22044.1 - 1.2e-07 31.7 0.0 1e-06 28.7 0.0 2.5 2 1 0 2 2 2 1 PX domain GDPD PF03009.17 KOS22045.1 - 5.7e-25 88.5 0.0 1e-18 68.0 0.0 2.6 1 1 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family SelP_N PF04592.14 KOS22045.1 - 2.8 7.3 7.2 4.1 6.7 7.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region GDPD_2 PF13653.6 KOS22045.1 - 5.7 7.5 9.2 15 6.2 0.1 3.5 3 0 0 3 3 3 0 Glycerophosphoryl diester phosphodiesterase family Plus-3 PF03126.18 KOS22046.1 - 4.1e-25 88.4 0.0 1.2e-24 86.9 0.0 1.9 1 0 0 1 1 1 1 Plus-3 domain TraF_2 PF13729.6 KOS22046.1 - 0.008 15.6 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 F plasmid transfer operon, TraF, protein Diphthamide_syn PF01866.17 KOS22047.1 - 5.1e-88 295.4 0.0 6.1e-88 295.1 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein MutS_V PF00488.21 KOS22048.1 - 1.4e-66 224.2 0.4 2.5e-66 223.3 0.4 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 KOS22048.1 - 1.1e-41 143.2 0.0 3.4e-41 141.6 0.0 1.9 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 KOS22048.1 - 7.4e-33 113.2 0.1 1.6e-32 112.1 0.1 1.6 1 0 0 1 1 1 1 MutS domain I MutS_IV PF05190.18 KOS22048.1 - 1.4e-13 51.0 0.1 5.3e-13 49.1 0.1 2.1 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 KOS22048.1 - 2.3e-13 50.6 0.0 1.1e-12 48.3 0.0 2.3 1 1 0 1 1 1 1 MutS domain II AAA_23 PF13476.6 KOS22048.1 - 0.0085 16.6 7.5 0.012 16.2 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_29 PF13555.6 KOS22048.1 - 0.035 13.8 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_27 PF13514.6 KOS22048.1 - 0.049 13.2 1.6 0.15 11.6 0.0 2.4 3 0 0 3 3 3 0 AAA domain AAA_21 PF13304.6 KOS22048.1 - 0.086 12.6 2.9 0.091 12.5 0.2 2.2 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF4366 PF14283.6 KOS22048.1 - 0.76 9.8 3.6 2.1 8.4 3.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Vpu PF00558.19 KOS22048.1 - 3.2 7.6 4.4 4.8 7.0 0.1 3.2 3 0 0 3 3 3 0 Vpu protein SLX9 PF15341.6 KOS22048.1 - 6.7 7.1 14.6 0.59 10.5 9.6 1.8 2 0 0 2 2 1 0 Ribosome biogenesis protein SLX9 MARVEL PF01284.23 KOS22049.1 - 4.6e-14 52.7 19.8 6.1e-14 52.3 19.8 1.1 1 0 0 1 1 1 1 Membrane-associating domain DUF5362 PF17319.2 KOS22049.1 - 1.3 8.9 7.8 0.73 9.7 1.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5362) MARVEL PF01284.23 KOS22050.1 - 0.022 14.8 8.3 0.03 14.3 8.3 1.2 1 0 0 1 1 1 0 Membrane-associating domain DUF4293 PF14126.6 KOS22050.1 - 0.1 12.9 2.1 0.086 13.1 0.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) DUF4199 PF13858.6 KOS22050.1 - 0.1 13.0 0.3 0.1 13.0 0.3 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF4199) Phage_holin_3_6 PF07332.11 KOS22050.1 - 1.3 9.1 7.2 0.11 12.5 1.3 2.1 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III DUF1129 PF06570.11 KOS22050.1 - 4.8 6.6 6.2 1.4 8.3 2.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) UbiA PF01040.18 KOS22052.1 - 7.3e-61 205.6 17.3 7.3e-61 205.6 17.3 1.7 1 1 1 2 2 2 1 UbiA prenyltransferase family Dabb PF07876.12 KOS22053.1 - 2.3e-11 44.1 0.0 2.9e-11 43.8 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain KR PF08659.10 KOS22054.1 - 1.5e-52 178.1 0.1 3.7e-52 176.8 0.1 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 KOS22054.1 - 2.9e-49 168.3 0.0 6.3e-49 167.2 0.0 1.5 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 KOS22054.1 - 8.2e-49 166.4 0.0 1.5e-48 165.6 0.0 1.4 1 0 0 1 1 1 1 Polyketide synthase dehydratase ketoacyl-synt PF00109.26 KOS22054.1 - 3e-45 154.8 1.3 1e-44 153.1 0.3 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 KOS22054.1 - 4.7e-35 120.2 0.3 2.4e-34 117.9 0.2 2.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 KOS22054.1 - 9.1e-16 58.3 0.0 4.6e-15 56.1 0.0 2.2 2 0 0 2 2 2 1 Ketoacyl-synthetase C-terminal extension adh_short PF00106.25 KOS22054.1 - 2.9e-13 49.7 0.0 1.4e-12 47.5 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase ADH_zinc_N PF00107.26 KOS22054.1 - 1.4e-09 38.0 0.4 2.1e-08 34.2 0.0 3.0 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Thiolase_N PF00108.23 KOS22054.1 - 0.00061 19.2 0.4 0.0018 17.7 0.4 1.7 1 0 0 1 1 1 1 Thiolase, N-terminal domain Epimerase PF01370.21 KOS22054.1 - 0.0027 17.2 0.0 0.0057 16.1 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family ADH_zinc_N_2 PF13602.6 KOS22054.1 - 0.0065 17.5 0.0 0.065 14.3 0.0 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase PP-binding PF00550.25 KOS22054.1 - 0.013 15.9 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 Phosphopantetheine attachment site DUF915 PF06028.11 KOS22054.1 - 0.19 11.1 0.0 0.34 10.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) MFS_1 PF07690.16 KOS22055.1 - 2.2e-10 40.0 27.0 1e-08 34.5 26.7 2.7 2 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 KOS22055.1 - 4.2e-08 32.1 12.3 4.8e-08 31.9 12.3 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF1761 PF08570.10 KOS22055.1 - 0.98 9.7 9.7 0.12 12.7 1.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1761) DUF1772 PF08592.11 KOS22055.1 - 8.1 6.8 14.6 2.5 8.4 1.7 3.8 2 2 2 4 4 4 0 Domain of unknown function (DUF1772) Annexin PF00191.20 KOS22056.1 - 7e-17 61.3 1.0 0.00013 21.9 0.0 4.4 4 0 0 4 4 4 4 Annexin Methyltransf_23 PF13489.6 KOS22057.1 - 0.00099 19.0 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS22057.1 - 0.016 15.2 0.0 0.032 14.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22057.1 - 0.057 14.1 0.0 0.18 12.5 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 KOS22057.1 - 0.075 12.8 0.0 0.15 11.8 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GidB PF02527.15 KOS22057.1 - 0.087 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G DUF2673 PF10880.8 KOS22057.1 - 0.096 12.8 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) eIF-5a PF01287.20 KOS22058.1 - 3.4e-05 23.9 0.0 6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Phage_holin_3_6 PF07332.11 KOS22059.1 - 0.34 11.0 11.8 0.36 10.9 11.8 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III SUR7 PF06687.12 KOS22059.1 - 4 7.0 14.0 5.3 6.6 14.0 1.1 1 0 0 1 1 1 0 SUR7/PalI family DUF2207 PF09972.9 KOS22059.1 - 9.8 4.8 19.1 11 4.6 19.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_C1_2 PF03051.15 KOS22060.1 - 7.9e-147 489.6 0.0 9.1e-147 489.4 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 KOS22060.1 - 2.7e-06 27.6 0.2 0.11 12.6 0.0 2.4 2 0 0 2 2 2 2 Papain family cysteine protease Ala_racemase_N PF01168.20 KOS22063.1 - 2e-24 86.5 0.0 2.4e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain DUF3192 PF11399.8 KOS22063.1 - 0.11 12.5 0.0 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3192) Adaptin_N PF01602.20 KOS22064.1 - 3.5e-121 405.3 13.0 4.2e-121 405.1 13.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 KOS22064.1 - 7.7e-45 151.7 0.0 2.7e-44 149.9 0.0 2.0 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 KOS22064.1 - 1.7e-16 60.5 0.0 3.6e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 Adaptin C-terminal domain RTP1_C1 PF10363.9 KOS22064.1 - 0.014 15.5 0.3 0.071 13.3 0.3 2.2 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 KOS22064.1 - 0.035 12.6 7.8 0.012 14.2 3.3 2.2 2 0 0 2 2 2 0 Proteasome non-ATPase 26S subunit HEAT PF02985.22 KOS22064.1 - 0.046 14.0 0.2 31 5.2 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat AP4E_app_platf PF14807.6 KOS22064.1 - 0.05 14.0 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Xpo1 PF08389.12 KOS22064.1 - 0.2 11.7 2.9 1.2 9.2 0.2 3.0 3 0 0 3 3 3 0 Exportin 1-like protein Methyltransf_23 PF13489.6 KOS22065.1 - 1.9e-09 37.6 0.0 3.1e-09 36.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22065.1 - 1.9e-09 38.0 0.0 4.2e-09 36.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22065.1 - 2e-07 31.6 0.0 5.1e-07 30.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22065.1 - 3.1e-07 31.0 0.0 5.4e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22065.1 - 1.3e-05 25.1 0.0 5.2e-05 23.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS22065.1 - 0.058 12.7 0.0 0.16 11.3 0.0 1.7 2 0 0 2 2 2 0 ubiE/COQ5 methyltransferase family PHO4 PF01384.20 KOS22066.1 - 1.5e-79 267.5 15.0 1.9e-79 267.1 15.0 1.1 1 0 0 1 1 1 1 Phosphate transporter family P16-Arc PF04699.14 KOS22066.1 - 3.6e-27 95.7 0.0 6.1e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) UPF0444 PF15475.6 KOS22066.1 - 0.14 12.5 5.5 0.84 9.9 0.4 2.7 2 0 0 2 2 2 0 Transmembrane protein C12orf23, UPF0444 peroxidase PF00141.23 KOS22067.1 - 2.3e-80 269.6 0.0 5.5e-48 163.7 0.0 2.3 2 0 0 2 2 2 2 Peroxidase UPF0113_N PF17833.1 KOS22069.1 - 3.3e-08 34.0 0.0 3.9e-08 33.7 0.0 1.0 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain PLDc_2 PF13091.6 KOS22070.1 - 4.7e-18 65.4 0.0 5e-12 45.9 0.0 3.2 3 1 0 3 3 3 2 PLD-like domain PLDc PF00614.22 KOS22070.1 - 8.5e-05 22.6 0.1 0.021 15.0 0.0 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif SRPRB PF09439.10 KOS22071.1 - 1.2e-26 93.3 0.0 1.9e-25 89.3 0.0 2.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Arf PF00025.21 KOS22071.1 - 2.9e-06 26.8 0.0 0.00034 20.1 0.0 2.8 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS22071.1 - 3.1e-06 27.3 0.0 4.7e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 KOS22071.1 - 0.00077 19.0 0.1 0.0088 15.6 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TniB PF05621.11 KOS22071.1 - 0.0057 16.1 0.0 0.0099 15.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein Roc PF08477.13 KOS22071.1 - 0.015 15.5 0.0 0.063 13.5 0.0 2.0 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 KOS22071.1 - 0.016 14.5 0.0 0.028 13.7 0.0 1.3 1 0 0 1 1 1 0 Septin Ras PF00071.22 KOS22071.1 - 0.017 14.7 0.0 0.062 12.9 0.0 1.9 2 0 0 2 2 2 0 Ras family AAA_16 PF13191.6 KOS22071.1 - 0.023 15.1 0.4 0.042 14.2 0.4 1.6 1 1 0 1 1 1 0 AAA ATPase domain MCM PF00493.23 KOS22071.1 - 0.045 12.8 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Gtr1_RagA PF04670.12 KOS22071.1 - 0.073 12.4 0.0 0.14 11.5 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region Dmrt1 PF12374.8 KOS22071.1 - 0.17 12.4 4.8 2 8.9 0.1 2.5 2 1 0 2 2 2 0 Double-sex mab3 related transcription factor 1 PALP PF00291.25 KOS22072.1 - 9.6e-67 225.4 0.2 9.6e-67 225.4 0.2 2.0 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 KOS22072.1 - 3e-11 43.6 0.0 1.1e-08 35.4 0.0 2.9 2 0 0 2 2 2 2 CBS domain HSF_DNA-bind PF00447.17 KOS22073.1 - 4.5e-29 100.9 0.2 1.6e-28 99.2 0.2 2.0 1 0 0 1 1 1 1 HSF-type DNA-binding Ets PF00178.22 KOS22073.1 - 0.16 12.5 0.0 0.37 11.3 0.0 1.6 1 0 0 1 1 1 0 Ets-domain Pro_isomerase PF00160.21 KOS22074.1 - 3e-44 151.1 0.0 6.2e-44 150.1 0.0 1.6 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Succ_DH_flav_C PF02910.20 KOS22074.1 - 0.26 11.3 2.3 1.3 9.0 0.1 2.3 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term Pro_isomerase PF00160.21 KOS22075.1 - 4.8e-48 163.4 0.0 5.5e-48 163.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF829 PF05705.14 KOS22077.1 - 4.6e-37 128.2 0.0 5.7e-37 127.9 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) MFS_1 PF07690.16 KOS22078.1 - 2.3e-39 135.3 29.6 2.3e-39 135.3 29.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Herpes_US9 PF06072.11 KOS22078.1 - 0.18 11.7 1.5 0.75 9.7 0.1 2.9 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 FAD_binding_4 PF01565.23 KOS22079.1 - 7.8e-09 35.4 0.0 1.3e-08 34.7 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Peptidase_M20 PF01546.28 KOS22080.1 - 5.2e-32 111.2 0.4 9.3e-32 110.4 0.4 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 KOS22080.1 - 3.3e-05 23.8 0.0 0.0001 22.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 KOS22080.1 - 0.00064 19.5 0.0 0.0017 18.1 0.0 1.7 2 0 0 2 2 2 1 Peptidase family M28 tRNA_int_end_N2 PF12928.7 KOS22081.1 - 2.2e-23 82.2 0.0 4.1e-23 81.4 0.0 1.5 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA_int_endo_N PF02778.14 KOS22081.1 - 0.0097 15.6 0.1 0.019 14.6 0.1 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain LysM PF01476.20 KOS22083.1 - 1.6e-07 31.2 0.0 2.4e-07 30.7 0.0 1.2 1 0 0 1 1 1 1 LysM domain Actino_peptide PF14408.6 KOS22083.1 - 0.016 15.3 0.4 0.016 15.3 0.4 2.0 2 0 0 2 2 2 0 Ribosomally synthesised peptide in actinomycetes DUF903 PF06004.12 KOS22083.1 - 0.036 14.0 0.7 0.1 12.5 0.7 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) HEAT_EZ PF13513.6 KOS22084.1 - 1.1e-21 76.9 12.3 5e-09 36.5 0.3 8.4 10 1 0 10 10 7 4 HEAT-like repeat HEAT PF02985.22 KOS22084.1 - 9.2e-21 72.2 8.8 0.0018 18.3 0.1 8.9 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 KOS22084.1 - 7.2e-18 64.8 8.8 0.031 14.7 0.2 8.1 6 1 3 9 9 9 5 HEAT repeats Vac14_Fab1_bd PF12755.7 KOS22084.1 - 4.8e-07 30.3 0.0 0.18 12.4 0.0 5.1 5 2 1 6 6 5 2 Vacuolar 14 Fab1-binding region IBN_N PF03810.19 KOS22084.1 - 9.7e-07 28.6 0.1 4.1e-06 26.6 0.1 2.1 1 0 0 1 1 1 1 Importin-beta N-terminal domain Cnd1 PF12717.7 KOS22084.1 - 1.2e-06 28.7 0.0 0.23 11.5 0.0 4.2 4 0 0 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 KOS22084.1 - 4.4e-06 25.5 0.0 0.056 12.0 0.0 4.0 3 2 0 4 4 4 2 Adaptin N terminal region UME PF08064.13 KOS22084.1 - 3e-05 23.9 1.0 3.3 7.7 0.0 5.1 6 0 0 6 6 6 2 UME (NUC010) domain RIX1 PF08167.12 KOS22084.1 - 8.1e-05 22.4 0.0 0.14 11.9 0.0 3.6 3 0 0 3 3 3 1 rRNA processing/ribosome biogenesis RTP1_C1 PF10363.9 KOS22084.1 - 0.00018 21.6 0.1 0.042 14.0 0.0 3.7 4 0 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 KOS22084.1 - 0.00043 20.2 6.2 0.93 9.6 0.0 6.7 7 0 0 7 7 7 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 KOS22084.1 - 0.00095 18.8 0.0 0.43 10.1 0.0 3.6 3 0 0 3 3 3 1 CLASP N terminal DUF3385 PF11865.8 KOS22084.1 - 0.046 13.6 0.2 45 3.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) Cohesin_HEAT PF12765.7 KOS22084.1 - 0.099 13.0 0.0 7.6 6.9 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion MMS19_C PF12460.8 KOS22084.1 - 0.15 11.1 0.9 0.78 8.8 0.2 2.6 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal DUF3730 PF12530.8 KOS22084.1 - 0.2 11.2 1.4 0.77 9.3 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3730) Asparaginase_2 PF01112.18 KOS22085.1 - 1.4e-56 191.8 4.7 5.5e-28 97.9 0.2 4.8 4 1 0 4 4 4 4 Asparaginase Sporozoite_P67 PF05642.11 KOS22085.1 - 7.1 4.6 5.6 10 4.0 5.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tim17 PF02466.19 KOS22086.1 - 1.9e-31 108.7 7.7 2.5e-31 108.3 7.7 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DLH PF01738.18 KOS22088.1 - 6e-22 78.3 0.0 7.5e-22 77.9 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family DUF747 PF05346.11 KOS22090.1 - 2.3e-118 395.3 7.3 2.7e-118 395.1 7.3 1.0 1 0 0 1 1 1 1 Eukaryotic membrane protein family OAD_gamma PF04277.13 KOS22090.1 - 0.014 15.9 0.3 0.034 14.7 0.3 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain HemY_N PF07219.13 KOS22090.1 - 0.023 14.9 0.6 0.073 13.3 0.6 1.9 1 0 0 1 1 1 0 HemY protein N-terminus PIR PF00399.19 KOS22091.1 - 2.1e-08 33.5 5.2 6.1e-08 32.0 5.2 1.9 1 0 0 1 1 1 1 Yeast PIR protein repeat Gpi16 PF04113.14 KOS22092.1 - 8.9e-240 796.9 0.0 1.1e-239 796.6 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component PMT PF02366.18 KOS22093.1 - 9.1e-86 287.4 13.0 9.1e-86 287.4 13.0 1.9 2 1 1 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 KOS22093.1 - 3.2e-65 219.5 11.9 3.2e-65 219.5 11.9 1.9 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 KOS22093.1 - 8.4e-36 123.6 0.8 1.3e-35 122.9 0.8 1.2 1 0 0 1 1 1 1 MIR domain DUF2976 PF11190.8 KOS22093.1 - 0.027 14.3 2.1 0.23 11.3 1.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) Ras PF00071.22 KOS22094.1 - 6.5e-48 162.4 0.0 8.8e-37 126.2 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 KOS22094.1 - 3.6e-28 98.2 0.0 5.5e-18 65.3 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS22094.1 - 3.5e-08 33.1 0.0 2.5e-07 30.3 0.0 2.3 2 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS22094.1 - 3.3e-05 23.5 0.0 0.00029 20.4 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS22094.1 - 0.00021 21.3 0.0 0.0011 19.1 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 KOS22094.1 - 0.0039 16.6 0.0 0.0069 15.8 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_22 PF13401.6 KOS22094.1 - 0.07 13.4 0.2 1.2 9.4 0.1 2.4 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 KOS22094.1 - 0.11 12.3 0.1 0.85 9.5 0.0 2.1 2 1 0 2 2 2 0 RsgA GTPase Choline_transpo PF04515.12 KOS22095.1 - 1.9e-30 106.2 22.6 1.9e-30 106.2 22.6 2.6 1 1 2 3 3 3 1 Plasma-membrane choline transporter WD40 PF00400.32 KOS22096.1 - 5.6e-08 33.3 7.9 0.87 10.6 0.2 5.8 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 KOS22096.1 - 0.016 13.8 0.1 0.92 8.1 0.0 2.8 3 0 0 3 3 3 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 KOS22096.1 - 0.023 15.0 0.1 19 5.6 0.0 4.4 3 1 2 5 5 5 0 Anaphase-promoting complex subunit 4 WD40 domain AMP-binding PF00501.28 KOS22097.1 - 4.1e-84 282.6 0.0 5e-84 282.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Cys_Met_Meta_PP PF01053.20 KOS22098.1 - 2.1e-150 500.6 0.0 2.3e-150 500.4 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 KOS22098.1 - 7.7e-10 38.5 0.0 1.2e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 KOS22098.1 - 1.3e-08 34.6 0.3 3.4e-08 33.2 0.2 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 KOS22098.1 - 2.8e-08 33.1 0.7 3.8e-08 32.7 0.2 1.4 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 KOS22098.1 - 3e-06 26.7 0.0 5.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Met_gamma_lyase PF06838.11 KOS22098.1 - 0.0014 17.2 0.1 0.0018 16.9 0.1 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase SepSecS PF05889.13 KOS22098.1 - 0.026 13.2 0.0 0.052 12.2 0.0 1.5 2 0 0 2 2 2 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Asparaginase_C PF17763.1 KOS22098.1 - 0.036 14.3 0.4 0.15 12.3 0.0 2.2 4 0 0 4 4 4 0 Glutaminase/Asparaginase C-terminal domain Ion_trans PF00520.31 KOS22099.1 - 0.002 17.4 13.6 0.0046 16.2 13.6 1.6 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOS22099.1 - 0.065 11.9 9.5 0.57 8.8 1.7 2.2 2 0 0 2 2 2 0 Polycystin cation channel DUF2012 PF09430.10 KOS22100.1 - 1.4e-21 76.8 0.0 1.9e-21 76.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2012) WW PF00397.26 KOS22101.1 - 8.3e-06 25.8 1.7 1.8e-05 24.8 1.7 1.6 1 0 0 1 1 1 1 WW domain TFIIA PF03153.13 KOS22101.1 - 0.053 13.5 4.3 0.088 12.8 4.3 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mito_carr PF00153.27 KOS22102.1 - 3.3e-28 97.4 4.8 2e-12 46.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein MBD PF01429.19 KOS22102.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Methyl-CpG binding domain Serine_protease PF18405.1 KOS22102.1 - 0.011 14.9 1.0 0.69 9.0 0.0 3.0 2 1 0 3 3 3 0 Gammaproteobacterial serine protease TFIIA PF03153.13 KOS22103.1 - 0.0011 19.1 5.9 0.0011 19.1 5.9 1.8 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit DUF2722 PF10846.8 KOS22103.1 - 0.0015 17.6 7.2 0.0024 16.9 7.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) DUF4407 PF14362.6 KOS22103.1 - 0.0024 17.3 2.7 0.0047 16.3 2.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Roughex PF06020.11 KOS22103.1 - 0.0033 16.6 2.4 0.0059 15.8 2.4 1.4 1 0 0 1 1 1 1 Drosophila roughex protein SLATT_5 PF18160.1 KOS22103.1 - 0.025 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Presenilin PF01080.17 KOS22103.1 - 0.5 9.1 2.0 1 8.1 2.0 1.4 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 KOS22103.1 - 0.92 9.1 21.7 2.1 7.9 21.7 1.5 1 0 0 1 1 1 0 Spt20 family ALMT PF11744.8 KOS22103.1 - 1.1 8.0 5.3 1.8 7.3 5.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2502 PF10697.9 KOS22103.1 - 2 8.8 9.7 19 5.7 0.0 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2502) Pex14_N PF04695.13 KOS22103.1 - 6.7 7.3 15.3 0.24 12.0 5.0 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region EphA2_TM PF14575.6 KOS22103.1 - 7.7 7.5 6.9 73 4.4 0.0 2.7 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4185 PF13810.6 KOS22104.1 - 1.1e-13 51.1 8.8 1.2e-12 47.7 8.7 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4185) DASH_Dad3 PF08656.10 KOS22105.1 - 4.9e-33 113.0 0.1 5.6e-33 112.9 0.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 Ribosomal_S5_C PF03719.15 KOS22106.1 - 1.1e-22 79.2 0.1 3.1e-21 74.6 0.0 3.0 3 0 0 3 3 3 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 KOS22106.1 - 6.9e-18 64.4 0.4 1.5e-17 63.3 0.4 1.6 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain SR-25 PF10500.9 KOS22106.1 - 0.23 11.0 4.0 0.51 9.9 4.0 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Adaptin_N PF01602.20 KOS22107.1 - 3.3e-95 319.6 2.4 5.4e-95 318.9 2.4 1.3 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 KOS22107.1 - 8.4e-59 197.5 0.0 1.8e-58 196.5 0.0 1.6 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 KOS22107.1 - 1.9e-56 189.5 0.0 5.3e-56 188.1 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 KOS22107.1 - 3.7e-14 53.1 1.5 3e-10 40.4 0.0 3.0 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS22107.1 - 5.5e-08 33.1 6.5 0.00011 22.5 0.0 5.2 2 1 2 5 5 5 2 HEAT repeats Coatomer_g_Cpla PF16381.5 KOS22107.1 - 9e-05 22.6 0.0 0.00031 20.8 0.0 2.0 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT PF02985.22 KOS22107.1 - 0.0061 16.7 0.5 11 6.6 0.0 4.6 4 0 0 4 4 4 1 HEAT repeat AP4E_app_platf PF14807.6 KOS22107.1 - 0.043 14.2 0.2 0.15 12.4 0.2 2.0 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Peptidase_M20 PF01546.28 KOS22108.1 - 6.2e-22 78.3 0.0 4.7e-21 75.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 WD40 PF00400.32 KOS22108.1 - 3.9e-15 56.0 9.2 0.0035 18.1 0.1 6.3 5 0 0 5 5 5 5 WD domain, G-beta repeat M20_dimer PF07687.14 KOS22108.1 - 0.00073 19.4 0.0 0.0015 18.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain ANAPC4_WD40 PF12894.7 KOS22108.1 - 0.0015 18.8 0.5 2.2 8.6 0.0 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 KOS22110.1 - 1.6e-42 142.7 16.2 1.8e-05 25.4 0.0 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat F-box-like PF12937.7 KOS22110.1 - 1.7e-10 40.6 0.7 3.7e-10 39.5 0.7 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS22110.1 - 1.7e-10 40.5 0.2 5.1e-10 39.0 0.2 1.9 1 0 0 1 1 1 1 F-box domain ANAPC4_WD40 PF12894.7 KOS22110.1 - 1.6e-07 31.5 0.3 2.5 8.4 0.0 5.3 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS22110.1 - 0.001 17.8 2.1 14 4.2 0.1 4.7 4 1 2 6 6 6 2 Nucleoporin Nup120/160 F-box_4 PF15966.5 KOS22110.1 - 0.028 14.3 0.0 0.064 13.1 0.0 1.6 1 0 0 1 1 1 0 F-box PRANC PF09372.10 KOS22110.1 - 0.052 13.9 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 PRANC domain DUF4328 PF14219.6 KOS22111.1 - 0.0099 15.4 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4328) Mito_fiss_reg PF05308.11 KOS22111.1 - 0.03 14.4 0.6 0.034 14.2 0.6 1.0 1 0 0 1 1 1 0 Mitochondrial fission regulator FPN1 PF06963.12 KOS22111.1 - 0.048 12.2 0.0 0.051 12.1 0.0 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) SARAF PF06682.12 KOS22111.1 - 0.084 12.5 0.0 0.093 12.4 0.0 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3169 PF11368.8 KOS22111.1 - 0.12 11.9 0.0 0.13 11.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) PSP1 PF04468.12 KOS22112.1 - 3.3e-27 94.6 2.0 7.5e-27 93.4 2.0 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region FAM70 PF14967.6 KOS22112.1 - 0.94 8.9 2.5 1.7 8.0 2.5 1.4 1 0 0 1 1 1 0 FAM70 protein Na_H_Exchanger PF00999.21 KOS22113.1 - 1.4e-41 142.6 14.0 1.9e-41 142.1 14.0 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family RNase_H PF00075.24 KOS22114.1 - 1.1e-36 126.1 0.0 1.1e-36 126.1 0.0 1.9 2 0 0 2 2 2 1 RNase H Cauli_VI PF01693.16 KOS22114.1 - 6.4e-35 119.2 11.2 5.3e-18 65.1 2.5 2.5 2 0 0 2 2 2 2 Caulimovirus viroplasmin Zip PF02535.22 KOS22114.1 - 0.085 12.1 2.1 0.1 11.8 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2370 PF10176.9 KOS22114.1 - 0.14 11.8 3.6 2.4 7.8 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) Neur_chan_memb PF02932.16 KOS22114.1 - 0.21 11.6 1.1 0.29 11.2 1.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region G0-G1_switch_2 PF15103.6 KOS22114.1 - 0.21 12.0 6.1 0.5 10.8 6.1 1.6 1 0 0 1 1 1 0 G0/G1 switch protein 2 Presenilin PF01080.17 KOS22114.1 - 0.23 10.2 1.4 0.28 9.9 1.4 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 KOS22114.1 - 1.1 9.0 4.5 2.1 8.0 4.5 1.4 1 0 0 1 1 1 0 FAM176 family SelP_N PF04592.14 KOS22114.1 - 1.2 8.4 16.5 1.8 7.9 16.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Roughex PF06020.11 KOS22114.1 - 1.7 7.7 5.3 2.4 7.1 5.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Spt20 PF12090.8 KOS22114.1 - 1.9 8.0 14.0 2.9 7.4 14.0 1.2 1 0 0 1 1 1 0 Spt20 family NicO PF03824.16 KOS22114.1 - 3.6 6.8 6.5 5.9 6.2 6.5 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Cwf_Cwc_15 PF04889.12 KOS22115.1 - 0.00043 20.1 6.2 0.00089 19.1 6.2 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 KOS22115.1 - 0.021 14.2 7.2 0.034 13.5 7.2 1.3 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 KOS22115.1 - 0.034 13.6 5.6 0.048 13.1 5.6 1.2 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS22115.1 - 0.087 11.1 4.8 0.11 10.7 4.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 KOS22115.1 - 0.14 10.3 6.9 0.21 9.8 6.9 1.2 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 KOS22115.1 - 0.59 9.8 4.9 1.3 8.6 4.9 1.6 1 0 0 1 1 1 0 FAM176 family YL1 PF05764.13 KOS22115.1 - 0.95 9.5 10.2 0.056 13.6 4.4 1.9 2 0 0 2 2 2 0 YL1 nuclear protein Ank_4 PF13637.6 KOS22116.1 - 1.3e-10 41.6 0.1 4.8e-10 39.8 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 KOS22116.1 - 7.4e-09 35.7 0.9 0.00076 19.8 0.3 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 KOS22116.1 - 7.7e-09 35.7 0.2 7.7e-08 32.5 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) TIG PF01833.24 KOS22116.1 - 2.1e-08 34.2 0.6 6.8e-08 32.5 0.5 1.9 2 0 0 2 2 1 1 IPT/TIG domain Ank_2 PF12796.7 KOS22116.1 - 1.1e-07 32.3 0.0 2.3e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS22116.1 - 9.1e-06 25.7 0.2 0.11 13.2 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat SDA1 PF05285.12 KOS22116.1 - 0.0011 18.4 20.4 0.002 17.6 20.4 1.3 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 KOS22116.1 - 0.0053 16.2 17.2 0.012 15.0 17.2 1.6 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 KOS22116.1 - 0.0087 14.3 27.0 0.014 13.7 27.0 1.2 1 0 0 1 1 1 1 Nop14-like family PPL5 PF18168.1 KOS22116.1 - 0.068 12.5 2.2 0.12 11.7 2.2 1.3 1 0 0 1 1 1 0 Prim-pol family 5 DUF740 PF05340.12 KOS22116.1 - 0.13 11.0 10.3 0.21 10.3 10.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Vfa1 PF08432.10 KOS22116.1 - 0.14 12.5 11.6 0.29 11.4 11.6 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RRN3 PF05327.11 KOS22116.1 - 0.15 10.6 9.9 0.23 9.9 9.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 KOS22116.1 - 0.3 10.6 23.3 0.73 9.4 23.3 1.6 1 0 0 1 1 1 0 PPP4R2 DUF3402 PF11882.8 KOS22116.1 - 0.39 9.8 3.8 0.67 9.0 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) Mpp10 PF04006.12 KOS22116.1 - 0.4 9.1 33.2 0.65 8.4 33.2 1.2 1 0 0 1 1 1 0 Mpp10 protein RR_TM4-6 PF06459.12 KOS22116.1 - 0.56 10.0 15.4 1.5 8.6 15.4 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4637 PF15470.6 KOS22116.1 - 0.66 9.7 18.3 1.8 8.3 18.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Merozoite_SPAM PF07133.11 KOS22116.1 - 0.82 9.6 35.0 1.6 8.7 35.0 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Pox_Ag35 PF03286.14 KOS22116.1 - 0.91 9.3 14.9 2.9 7.7 14.9 1.8 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 KOS22116.1 - 1.5 7.0 19.4 2.4 6.4 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 KOS22116.1 - 1.7 6.6 35.5 2.7 6.0 35.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SpoIIIAH PF12685.7 KOS22116.1 - 2.8 7.7 15.4 7 6.4 15.4 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein Hid1 PF12722.7 KOS22116.1 - 6.5 4.7 7.5 11 4.0 7.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 KOS22116.1 - 7 5.5 7.9 14 4.5 7.9 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Paf1 PF03985.13 KOS22116.1 - 8.3 5.3 26.8 13 4.6 26.8 1.2 1 0 0 1 1 1 0 Paf1 Zip PF02535.22 KOS22116.1 - 8.5 5.5 7.0 15 4.6 7.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Arm PF00514.23 KOS22117.1 - 1.7e-08 34.2 17.9 8.7e-05 22.4 0.4 7.3 9 0 0 9 9 9 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 KOS22117.1 - 0.0096 16.4 0.0 0.0096 16.4 0.0 6.1 6 2 3 9 9 9 1 HEAT-like repeat V-ATPase_H_C PF11698.8 KOS22117.1 - 0.013 15.6 0.4 0.84 9.8 0.0 3.0 1 1 1 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 KOS22117.1 - 0.013 15.7 17.2 0.79 10.1 0.2 7.1 8 0 0 8 8 8 0 HEAT repeat IFRD PF05004.13 KOS22117.1 - 0.017 14.2 0.1 0.017 14.2 0.1 2.3 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) DUF913 PF06025.12 KOS22117.1 - 0.37 9.7 1.2 1.8 7.4 0.8 2.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) DUF3361 PF11841.8 KOS22117.1 - 1.4 8.8 3.3 3 7.8 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) RHIM PF12721.7 KOS22117.1 - 4.4 7.9 4.6 2.3 8.8 1.8 2.0 2 0 0 2 2 2 0 RIP homotypic interaction motif Velvet PF11754.8 KOS22118.1 - 6.6e-54 183.5 1.7 2.1e-33 116.4 0.0 2.9 2 1 1 3 3 3 2 Velvet factor Chorion_2 PF03964.15 KOS22118.1 - 0.034 15.0 8.8 0.08 13.8 8.8 1.6 1 0 0 1 1 1 0 Chorion family 2 SARG PF15385.6 KOS22118.1 - 0.13 11.5 3.5 0.17 11.0 3.5 1.2 1 0 0 1 1 1 0 Specifically androgen-regulated gene protein ASFV_J13L PF05568.11 KOS22118.1 - 0.73 9.6 4.9 1.2 8.8 4.3 1.6 2 0 0 2 2 2 0 African swine fever virus J13L protein DUF2556 PF10831.8 KOS22119.1 - 0.21 11.6 0.6 0.3 11.1 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) Cyclin PF08613.11 KOS22120.1 - 7.8e-31 107.6 0.2 1.6e-30 106.6 0.2 1.8 1 1 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 KOS22120.1 - 0.0002 21.1 0.0 0.00032 20.4 0.0 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Use1 PF09753.9 KOS22121.1 - 0.00037 20.3 0.0 0.00052 19.8 0.0 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 CHZ PF09649.10 KOS22122.1 - 4.6e-14 51.6 0.8 4.6e-14 51.6 0.8 3.0 4 0 0 4 4 4 1 Histone chaperone domain CHZ Vfa1 PF08432.10 KOS22122.1 - 6.6 7.0 9.9 11 6.3 9.6 1.5 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PAP2 PF01569.21 KOS22123.1 - 1.1e-17 64.1 7.6 3.1e-17 62.6 7.6 1.8 1 0 0 1 1 1 1 PAP2 superfamily PAP2_3 PF14378.6 KOS22123.1 - 0.13 11.9 14.2 0.2 11.3 12.1 2.5 1 1 0 1 1 1 0 PAP2 superfamily AAA PF00004.29 KOS22124.1 - 3.7e-14 53.3 0.0 1.5e-13 51.3 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 KOS22124.1 - 2.9e-13 50.0 0.0 6.5e-13 48.9 0.0 1.6 1 0 0 1 1 1 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 KOS22124.1 - 3.4e-11 43.2 0.0 1.8e-07 31.1 0.0 2.4 2 0 0 2 2 2 2 DNA polymerase III, delta subunit Rad17 PF03215.15 KOS22124.1 - 9.1e-08 32.2 0.0 2.1e-07 31.0 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 KOS22124.1 - 4.7e-07 30.0 0.2 2.1e-06 28.0 0.0 2.2 2 1 1 3 3 2 1 AAA C-terminal domain AAA_30 PF13604.6 KOS22124.1 - 1.8e-06 27.8 0.1 5.3e-06 26.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 KOS22124.1 - 1.7e-05 25.3 0.0 0.00022 21.7 0.0 2.5 2 1 0 3 3 3 1 AAA ATPase domain AAA_11 PF13086.6 KOS22124.1 - 2.1e-05 24.5 0.1 0.00024 21.0 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KOS22124.1 - 4e-05 23.9 0.1 0.00042 20.6 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS22124.1 - 4.6e-05 23.4 0.1 0.00052 20.0 0.0 2.6 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 KOS22124.1 - 7.3e-05 22.1 0.0 0.00013 21.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 KOS22124.1 - 0.00025 20.8 0.0 0.00062 19.5 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_24 PF13479.6 KOS22124.1 - 0.00031 20.5 0.0 0.00062 19.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain DNA_pol3_delta PF06144.13 KOS22124.1 - 0.00034 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_19 PF13245.6 KOS22124.1 - 0.0017 18.7 0.8 0.0054 17.1 0.0 2.1 2 1 0 2 2 2 1 AAA domain PhoH PF02562.16 KOS22124.1 - 0.0026 17.2 0.0 0.22 10.9 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_14 PF13173.6 KOS22124.1 - 0.0058 16.7 0.0 0.043 13.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 KOS22124.1 - 0.0059 16.0 0.2 0.032 13.6 0.1 2.2 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 KOS22124.1 - 0.0061 16.6 0.0 0.044 13.8 0.0 2.0 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_3 PF07726.11 KOS22124.1 - 0.0086 15.9 0.0 0.049 13.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 KOS22124.1 - 0.0099 16.1 0.0 0.024 14.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOS22124.1 - 0.015 15.9 0.0 0.032 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 KOS22124.1 - 0.015 14.7 0.0 0.088 12.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_25 PF13481.6 KOS22124.1 - 0.045 13.3 0.0 0.15 11.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 KOS22124.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 KOS22124.1 - 0.081 12.7 0.0 1 9.1 0.0 2.3 1 1 0 2 2 2 0 DEAD/DEAH box helicase RNA_helicase PF00910.22 KOS22124.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase BTB_2 PF02214.22 KOS22125.1 - 2.7e-06 27.7 0.0 8.3e-05 22.9 0.0 2.5 2 0 0 2 2 2 1 BTB/POZ domain SMBP PF16785.5 KOS22126.1 - 5.4 7.3 8.6 0.35 11.1 2.4 2.1 2 0 0 2 2 2 0 Small metal-binding protein Cyt-b5 PF00173.28 KOS22127.1 - 3.8e-11 43.0 0.0 5.6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cu_bind_like PF02298.17 KOS22128.1 - 0.00035 20.5 0.1 0.00084 19.3 0.1 1.7 1 1 0 1 1 1 1 Plastocyanin-like domain CENP-X PF09415.10 KOS22129.1 - 4.6e-23 81.3 0.1 9.2e-23 80.4 0.1 1.5 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CDC45 PF02724.14 KOS22129.1 - 2.2 6.5 5.5 2.3 6.4 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 KOS22129.1 - 9 5.5 11.1 11 5.3 11.1 1.1 1 0 0 1 1 1 0 NOA36 protein Mito_carr PF00153.27 KOS22130.1 - 3.8e-66 219.0 4.2 1.9e-24 85.4 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF4748 PF15932.5 KOS22130.1 - 0.05 13.4 1.3 0.18 11.6 1.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) Ribosomal_S25 PF03297.15 KOS22131.1 - 1e-36 125.2 4.8 1.1e-36 125.1 4.8 1.0 1 0 0 1 1 1 1 S25 ribosomal protein DUF3181 PF11378.8 KOS22131.1 - 0.03 14.6 0.0 0.037 14.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3181) HTH_24 PF13412.6 KOS22131.1 - 0.032 13.8 0.1 0.049 13.2 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 KOS22131.1 - 0.047 14.0 0.0 0.072 13.4 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator Ribosomal_S7 PF00177.21 KOS22132.1 - 1.7e-37 128.3 2.0 2.2e-37 128.0 2.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Melibiase_2 PF16499.5 KOS22133.1 - 6e-12 45.3 3.9 5.1e-05 22.6 0.0 2.2 1 1 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 KOS22133.1 - 8.5e-12 45.0 0.1 1.9e-11 43.9 0.1 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Glyco_transf_28 PF03033.20 KOS22134.1 - 3.7e-17 62.7 0.0 8e-17 61.6 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain UDPGT PF00201.18 KOS22134.1 - 4e-05 22.6 0.0 5.8e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KOS22134.1 - 0.0002 21.3 0.0 0.00034 20.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain VPS13_C PF16909.5 KOS22134.1 - 0.28 11.0 0.8 4.8 6.9 0.1 2.2 1 1 1 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal Methyltransf_PK PF05891.12 KOS22135.1 - 3.8e-59 199.8 0.0 4.3e-59 199.7 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KOS22135.1 - 0.0015 19.2 0.0 0.0023 18.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 KOS22135.1 - 0.0047 16.2 0.0 0.0059 15.9 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_12 PF08242.12 KOS22135.1 - 0.011 16.4 0.0 0.019 15.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22135.1 - 0.028 15.1 0.0 0.042 14.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain B_lectin PF01453.24 KOS22136.1 - 1.8e-09 38.1 0.0 2.1e-06 28.2 0.1 2.1 1 1 1 2 2 2 2 D-mannose binding lectin PQQ PF01011.21 KOS22136.1 - 0.081 12.9 1.5 5.3 7.1 0.1 3.0 3 1 0 3 3 3 0 PQQ enzyme repeat RNase_HII PF01351.18 KOS22137.1 - 6.6e-48 163.2 0.0 6.4e-46 156.7 0.0 2.0 1 1 0 1 1 1 1 Ribonuclease HII RHD3 PF05879.12 KOS22138.1 - 0 1018.2 0.0 0 1018.0 0.0 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 KOS22138.1 - 8.8e-08 31.7 0.1 1.5e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 KOS22138.1 - 5.6e-06 26.5 0.0 1.1e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 KOS22138.1 - 8.3e-05 22.6 0.1 0.00029 20.9 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 KOS22138.1 - 0.0028 17.9 0.0 0.0058 16.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain Septin PF00735.18 KOS22138.1 - 0.022 14.0 0.1 0.036 13.3 0.1 1.3 1 0 0 1 1 1 0 Septin DUF3693 PF12472.8 KOS22138.1 - 0.036 13.7 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 Phage related protein RNA12 PF10443.9 KOS22139.1 - 5.3e-151 503.3 0.0 8e-151 502.7 0.0 1.3 1 0 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 KOS22139.1 - 1.9e-09 37.8 0.1 0.00091 19.2 0.0 2.3 2 0 0 2 2 2 2 ATPase domain predominantly from Archaea RRM_1 PF00076.22 KOS22139.1 - 2e-05 24.3 0.0 5.6e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_16 PF13191.6 KOS22139.1 - 0.00038 20.9 0.1 0.0018 18.7 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain DUF2487 PF10673.9 KOS22139.1 - 0.079 13.0 0.1 0.22 11.6 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2487) CENP-C_C PF11699.8 KOS22140.1 - 1.1e-33 115.3 0.1 1.6e-33 114.8 0.1 1.3 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_2 PF07883.11 KOS22140.1 - 3.2e-08 33.2 0.1 4.3e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 Cupin domain Cupin_1 PF00190.22 KOS22140.1 - 0.0028 17.3 0.0 0.004 16.8 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_3 PF05899.12 KOS22140.1 - 0.0059 16.3 0.5 0.037 13.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF861) AraC_binding PF02311.19 KOS22140.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 AraC-like ligand binding domain HSP70 PF00012.20 KOS22141.1 - 7.9e-259 859.9 5.2 8.9e-259 859.7 5.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS22141.1 - 1.3e-17 63.6 0.0 3.6e-16 58.9 0.0 2.1 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 KOS22141.1 - 0.0014 18.4 0.0 0.0038 17.0 0.0 1.7 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 KOS22141.1 - 0.033 13.4 0.1 0.064 12.5 0.1 1.4 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase StbA PF06406.11 KOS22141.1 - 0.045 13.0 0.0 0.08 12.2 0.0 1.4 1 0 0 1 1 1 0 StbA protein PMBR PF09373.10 KOS22141.1 - 0.16 12.2 0.8 0.42 10.9 0.0 2.2 2 0 0 2 2 2 0 Pseudomurein-binding repeat FtsA PF14450.6 KOS22141.1 - 0.19 12.2 2.2 37 4.8 0.1 3.3 3 2 0 3 3 3 0 Cell division protein FtsA MetOD2 PF18548.1 KOS22141.1 - 0.42 10.7 3.2 2.3 8.4 0.1 2.5 2 0 0 2 2 2 0 Metanogen output domain 2 ISG65-75 PF11727.8 KOS22141.1 - 6.9 5.8 9.1 7.5 5.7 5.5 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF3128 PF11326.8 KOS22142.1 - 2.6e-23 82.2 1.4 3.7e-23 81.7 1.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) Peptidase_C2 PF00648.21 KOS22143.1 - 6.9e-60 202.6 0.9 2.1e-58 197.7 0.9 2.2 1 1 0 1 1 1 1 Calpain family cysteine protease AA_permease PF00324.21 KOS22144.1 - 5.4e-137 457.3 46.9 6.4e-137 457.0 46.9 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS22144.1 - 1.7e-35 122.7 52.6 2.3e-35 122.3 52.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF4781 PF16013.5 KOS22144.1 - 0.84 8.4 5.0 0.13 11.0 1.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4781) Acetyltransf_1 PF00583.25 KOS22145.1 - 4.4e-07 30.1 0.0 1.2e-06 28.7 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS22145.1 - 4.5e-06 26.6 0.0 8.2e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22145.1 - 7.9e-05 23.0 0.0 0.00032 21.0 0.0 2.0 3 0 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS22145.1 - 0.0082 16.2 0.0 0.17 11.9 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain NicO PF03824.16 KOS22146.1 - 1e-63 215.4 9.5 1.4e-63 214.9 9.5 1.2 1 0 0 1 1 1 1 High-affinity nickel-transport protein Ldh_2 PF02615.14 KOS22147.1 - 3e-122 408.0 3.0 3.4e-122 407.8 3.0 1.0 1 0 0 1 1 1 1 Malate/L-lactate dehydrogenase SET PF00856.28 KOS22148.1 - 3.3e-10 40.6 0.8 3.5e-09 37.3 0.0 2.6 2 1 1 3 3 3 1 SET domain Tmemb_55A PF09788.9 KOS22148.1 - 0.0058 15.8 0.3 0.016 14.3 0.3 1.7 1 0 0 1 1 1 1 Transmembrane protein 55A Trypan_PARP PF05887.11 KOS22148.1 - 2.3 8.2 28.3 3.1 7.8 26.5 2.2 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Peptidase_M28 PF04389.17 KOS22149.1 - 9.3e-40 136.4 0.1 1.9e-39 135.4 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 KOS22149.1 - 3.1e-13 49.6 0.6 1.5e-12 47.3 0.4 2.3 2 0 0 2 2 2 1 PA domain Peptidase_M20 PF01546.28 KOS22149.1 - 0.00023 20.9 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 KOS22149.1 - 0.041 12.9 0.0 0.26 10.3 0.0 2.0 2 0 0 2 2 2 0 M42 glutamyl aminopeptidase Ribosomal_L30 PF00327.20 KOS22150.1 - 1.1e-16 60.4 0.0 1.8e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e CoA_binding PF02629.19 KOS22151.1 - 1.2e-19 70.8 0.0 3.2e-19 69.4 0.0 1.8 1 0 0 1 1 1 1 CoA binding domain Citrate_synt PF00285.21 KOS22151.1 - 1.4e-19 70.4 0.0 6.2e-16 58.4 0.0 2.9 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain Ligase_CoA PF00549.19 KOS22151.1 - 1.8e-15 57.1 0.0 3.4e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 KOS22151.1 - 3.2e-06 27.0 0.0 0.00015 21.6 0.0 2.5 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CEP1-DNA_bind PF09287.10 KOS22151.1 - 0.12 12.0 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 CEP-1, DNA binding CENP-Q PF13094.6 KOS22152.1 - 1.5e-45 155.4 0.4 1.5e-45 155.4 0.4 2.0 2 0 0 2 2 2 1 CENP-Q, a CENPA-CAD centromere complex subunit RTP1_C2 PF10304.9 KOS22154.1 - 7e-12 44.8 0.3 1.3e-11 44.0 0.3 1.5 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 RTP1_C1 PF10363.9 KOS22154.1 - 1.7e-06 28.2 0.2 4e-06 27.0 0.2 1.7 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 Tudor-knot PF11717.8 KOS22156.1 - 6.9e-08 32.3 0.7 3.9e-07 29.8 0.2 2.0 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain Agenet PF05641.12 KOS22156.1 - 0.057 13.9 0.1 0.14 12.7 0.0 1.6 2 0 0 2 2 2 0 Agenet domain MRG PF05712.13 KOS22157.1 - 5.2e-51 172.8 0.0 9.1e-50 168.7 0.0 2.0 1 1 0 1 1 1 1 MRG NAD_binding_4 PF07993.12 KOS22158.1 - 3.8e-68 229.4 0.0 5.3e-68 229.0 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 KOS22158.1 - 1.1e-59 202.2 0.0 4.6e-59 200.1 0.0 2.0 2 0 0 2 2 2 1 AMP-binding enzyme Cnl2_NKP2 PF09447.10 KOS22158.1 - 2.2e-21 75.7 0.1 5.2e-21 74.6 0.1 1.7 1 0 0 1 1 1 1 Cnl2/NKP2 family protein Epimerase PF01370.21 KOS22158.1 - 3.2e-11 43.2 0.0 7.1e-11 42.0 0.0 1.6 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family PP-binding PF00550.25 KOS22158.1 - 2.8e-08 34.0 0.0 6.3e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site 3Beta_HSD PF01073.19 KOS22158.1 - 2.4e-07 30.0 0.0 8.7e-07 28.2 0.0 1.8 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family AMP-binding_C PF13193.6 KOS22158.1 - 0.00017 22.5 0.0 0.0018 19.2 0.0 2.8 2 1 0 2 2 2 1 AMP-binding enzyme C-terminal domain NAD_binding_10 PF13460.6 KOS22158.1 - 0.015 15.2 0.1 0.087 12.7 0.1 2.3 1 1 0 1 1 1 0 NAD(P)H-binding RmlD_sub_bind PF04321.17 KOS22158.1 - 0.074 12.1 0.0 0.19 10.8 0.0 1.7 1 1 0 1 1 1 0 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KOS22158.1 - 0.19 11.1 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Meth_synt_2 PF01717.18 KOS22159.1 - 1.6e-152 507.4 0.0 2.7e-146 487.0 0.0 2.6 2 0 0 2 2 2 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 KOS22159.1 - 5.1e-116 387.6 0.0 9.1e-110 367.0 0.0 2.6 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain URO-D PF01208.17 KOS22159.1 - 0.0057 15.9 0.0 0.33 10.0 0.0 2.6 2 1 0 2 2 2 1 Uroporphyrinogen decarboxylase (URO-D) VbhA PF18495.1 KOS22159.1 - 0.027 14.4 0.0 14 5.6 0.0 2.8 2 0 0 2 2 2 0 Antitoxin VbhA DIT1_PvcA PF05141.12 KOS22160.1 - 3.6e-94 315.3 0.0 4.6e-94 315.0 0.0 1.1 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein TauD PF02668.16 KOS22160.1 - 7.9e-18 65.2 0.0 1.9e-17 64.0 0.0 1.7 1 1 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family FAD_binding_3 PF01494.19 KOS22161.1 - 5.7e-37 127.8 0.0 9.2e-37 127.1 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DEAD PF00270.29 KOS22162.1 - 1.2e-39 135.8 0.0 2.7e-39 134.7 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS22162.1 - 4.5e-26 91.4 0.0 1.6e-25 89.6 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain TPR_MLP1_2 PF07926.12 KOS22163.1 - 4.2e-39 133.5 30.4 4.2e-39 133.5 30.4 19.6 8 5 11 19 19 19 5 TPR/MLP1/MLP2-like protein Cluap1 PF10234.9 KOS22163.1 - 5.3e-05 22.8 16.8 5.3e-05 22.8 16.8 13.2 6 4 6 13 13 13 1 Clusterin-associated protein-1 CENP-F_leu_zip PF10473.9 KOS22163.1 - 0.0061 16.6 24.7 0.0061 16.6 24.7 17.3 5 4 11 18 18 18 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 KOS22163.1 - 0.89 10.0 0.0 0.89 10.0 0.0 17.5 16 2 2 18 18 18 0 Lipoprotein leucine-zipper HSBP1 PF06825.12 KOS22163.1 - 1.9 8.4 16.1 0.23 11.4 0.5 6.4 5 0 0 5 5 5 0 Heat shock factor binding protein 1 Hce2 PF14856.6 KOS22164.1 - 1.8e-10 41.0 0.0 2.7e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Pathogen effector; putative necrosis-inducing factor Hira PF07569.11 KOS22166.1 - 7.9e-83 277.5 0.1 3.7e-82 275.4 0.0 2.1 2 0 0 2 2 2 1 TUP1-like enhancer of split WD40 PF00400.32 KOS22166.1 - 3.4e-31 106.8 23.2 5.3e-05 23.9 0.1 8.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22166.1 - 1.1e-16 60.9 0.0 0.015 15.5 0.0 6.5 3 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain HIRA_B PF09453.10 KOS22166.1 - 1.4e-09 37.6 0.3 1.4e-09 37.6 0.3 2.0 2 0 0 2 2 2 1 HIRA B motif PD40 PF07676.12 KOS22166.1 - 5.7e-05 22.9 2.0 16 5.6 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 KOS22166.1 - 0.0038 16.2 1.3 0.19 10.7 0.0 3.7 4 1 1 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 KOS22166.1 - 0.056 11.4 0.0 0.19 9.7 0.0 1.7 2 0 0 2 2 2 0 IKI3 family SDA1 PF05285.12 KOS22166.1 - 0.1 12.0 7.0 0.16 11.4 7.0 1.2 1 0 0 1 1 1 0 SDA1 NACHT_N PF17100.5 KOS22167.1 - 1.9e-31 109.6 0.0 2.7e-31 109.1 0.0 1.1 1 0 0 1 1 1 1 N-terminal domain of NWD NACHT-NTPase Glyco_transf_15 PF01793.16 KOS22169.1 - 1.4e-42 146.1 0.0 3e-41 141.8 0.0 2.2 1 1 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CcmD PF04995.14 KOS22169.1 - 0.084 13.0 2.4 0.2 11.8 2.4 1.7 1 0 0 1 1 1 0 Heme exporter protein D (CcmD) Helicase_C_2 PF13307.6 KOS22170.1 - 5.4e-38 130.8 0.0 6.3e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Helicase C-terminal domain PNISR PF15996.5 KOS22170.1 - 0.076 13.3 0.1 0.14 12.5 0.1 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Transp_cyt_pur PF02133.15 KOS22171.1 - 0.082 11.7 0.0 0.093 11.5 0.0 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin NIF PF03031.18 KOS22172.1 - 2.6e-26 92.3 0.0 6e-26 91.1 0.0 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 KOS22172.1 - 1.9e-07 31.3 0.0 4.7e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 KOS22172.1 - 1.9e-05 24.5 0.2 7.5e-05 22.6 0.0 2.2 2 1 1 3 3 3 1 twin BRCT domain RTT107_BRCT_5 PF16770.5 KOS22172.1 - 0.0084 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 KOS22172.1 - 0.017 15.5 0.0 0.04 14.3 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Herpes_UL14 PF03580.14 KOS22172.1 - 0.059 13.6 0.5 0.059 13.6 0.5 2.4 2 1 0 2 2 2 0 Herpesvirus UL14-like protein Ribosomal_S2 PF00318.20 KOS22172.1 - 0.089 12.0 0.0 0.21 10.8 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein S2 LIG3_BRCT PF16759.5 KOS22172.1 - 0.13 12.6 0.1 0.28 11.5 0.1 1.5 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain BRCT_3 PF18428.1 KOS22172.1 - 0.2 11.7 0.9 0.38 10.9 0.1 1.8 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Cnd1_N PF12922.7 KOS22173.1 - 9.8e-60 201.2 0.0 4.6e-59 199.0 0.0 2.2 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term Cnd1 PF12717.7 KOS22173.1 - 8.8e-49 165.6 6.0 1.6e-45 155.1 0.3 3.8 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 KOS22173.1 - 1.3e-10 40.6 3.2 0.01 16.0 0.0 5.6 5 0 0 5 5 4 2 HEAT repeat HEAT_2 PF13646.6 KOS22173.1 - 3.8e-10 40.0 1.9 2.9e-05 24.4 0.1 4.4 3 1 0 4 4 4 2 HEAT repeats Adaptin_N PF01602.20 KOS22173.1 - 1.3e-05 24.0 5.8 0.0013 17.4 0.2 3.7 4 0 0 4 4 4 2 Adaptin N terminal region HEAT_EZ PF13513.6 KOS22173.1 - 2.9e-05 24.4 8.8 0.0073 16.8 0.1 5.4 5 1 0 5 5 5 1 HEAT-like repeat Cnd3 PF12719.7 KOS22173.1 - 0.0003 20.1 3.9 0.0017 17.6 1.1 3.5 4 1 0 4 4 4 1 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 KOS22173.1 - 0.00041 20.5 0.0 0.41 10.8 0.0 3.5 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 DUF2408 PF10303.9 KOS22173.1 - 0.074 13.6 0.7 1.5 9.4 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2408) Ald_Xan_dh_C2 PF02738.18 KOS22173.1 - 0.1 11.1 0.0 0.16 10.4 0.0 1.2 1 0 0 1 1 1 0 Molybdopterin-binding domain of aldehyde dehydrogenase MIEAP PF16026.5 KOS22173.1 - 0.11 12.7 1.3 0.43 10.8 0.1 2.6 3 0 0 3 3 3 0 Mitochondria-eating protein Pkinase PF00069.25 KOS22174.1 - 1.2e-41 142.8 0.0 2.5e-38 132.0 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22174.1 - 2.3e-14 53.3 0.0 5.5e-09 35.7 0.0 3.6 3 1 0 3 3 3 2 Protein tyrosine kinase APH PF01636.23 KOS22174.1 - 0.00022 21.2 0.4 0.004 17.1 0.1 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 KOS22174.1 - 0.0045 15.8 0.0 0.0067 15.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS22174.1 - 0.052 12.9 0.0 7.8 5.7 0.0 2.2 2 0 0 2 2 2 0 Kinase-like FTA2 PF13095.6 KOS22174.1 - 0.066 12.8 0.0 0.88 9.2 0.0 2.5 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOS22174.1 - 0.13 11.6 0.0 0.85 8.9 0.0 2.1 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L27A PF00828.19 KOS22175.1 - 2.8e-20 73.3 0.0 3.8e-20 72.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A PknG_TPR PF16918.5 KOS22175.1 - 0.17 10.6 0.0 0.2 10.3 0.0 1.1 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat WD40 PF00400.32 KOS22176.1 - 2.3e-07 31.4 5.2 0.16 12.9 0.0 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat Glyco_transf_28 PF03033.20 KOS22177.1 - 1.1e-28 100.0 0.0 2e-28 99.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 N-terminal domain GRAM PF02893.20 KOS22177.1 - 2.8e-26 91.6 1.3 4.4e-20 71.7 0.0 2.3 2 0 0 2 2 2 2 GRAM domain PH PF00169.29 KOS22177.1 - 2.1e-13 50.7 0.3 1.1e-12 48.4 0.0 2.3 3 0 0 3 3 3 1 PH domain UDPGT PF00201.18 KOS22177.1 - 3.3e-06 26.2 0.0 5.5e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_8 PF15409.6 KOS22177.1 - 0.00012 22.3 0.0 0.00023 21.4 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 KOS22177.1 - 0.0014 19.0 2.7 0.0056 17.1 0.6 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 KOS22177.1 - 0.06 13.5 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 PH domain PH_2 PF08458.10 KOS22177.1 - 0.062 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_6 PF15406.6 KOS22177.1 - 0.069 13.4 0.3 0.86 9.9 0.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain GRIM-19 PF06212.12 KOS22179.1 - 1.1e-24 86.9 0.1 1.9e-24 86.1 0.1 1.4 1 1 0 1 1 1 1 GRIM-19 protein Steroid_dh PF02544.16 KOS22180.1 - 7.4e-26 90.9 1.0 1.1e-25 90.4 1.0 1.2 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KOS22180.1 - 0.0047 16.5 2.5 0.0056 16.2 1.5 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) DUF621 PF04789.15 KOS22180.1 - 0.048 12.8 1.2 0.074 12.2 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) Snapin_Pallidin PF14712.6 KOS22181.1 - 0.032 14.6 2.2 0.068 13.6 2.1 1.6 1 1 0 1 1 1 0 Snapin/Pallidin DUF349 PF03993.12 KOS22181.1 - 0.062 13.6 1.0 0.12 12.7 1.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) Ctf8 PF09696.10 KOS22182.1 - 5e-38 130.6 0.1 2.7e-37 128.2 0.1 1.9 1 1 0 1 1 1 1 Ctf8 Diphthamide_syn PF01866.17 KOS22183.1 - 2e-116 388.7 0.0 2.7e-116 388.2 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Aldose_epim PF01263.20 KOS22183.1 - 1.4e-43 149.3 0.0 2e-43 148.8 0.0 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase ATP-synt_ab PF00006.25 KOS22184.1 - 2.9e-65 219.9 0.0 4.6e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 KOS22184.1 - 1.3e-14 54.5 0.9 2.7e-14 53.4 0.9 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain DUF5535 PF17687.1 KOS22184.1 - 0.03 14.5 0.0 0.075 13.2 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5535) HMGL-like PF00682.19 KOS22185.1 - 1.8e-42 145.7 0.1 5.6e-42 144.1 0.1 1.7 1 1 0 1 1 1 1 HMGL-like Ribosomal_S8e PF01201.22 KOS22186.1 - 7.6e-55 184.8 1.6 8.9e-55 184.6 1.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S8e RabGAP-TBC PF00566.18 KOS22187.1 - 2.3e-46 158.2 9.6 1.2e-45 155.8 0.1 3.5 2 1 1 3 3 3 1 Rab-GTPase-TBC domain HALZ PF02183.18 KOS22187.1 - 0.0011 19.1 0.8 0.0011 19.1 0.8 4.2 4 0 0 4 4 4 1 Homeobox associated leucine zipper YabA PF06156.13 KOS22187.1 - 0.018 15.7 3.3 0.018 15.7 3.3 5.3 5 1 1 6 6 6 0 Initiation control protein YabA PspB PF06667.12 KOS22187.1 - 0.11 12.6 1.5 0.69 10.0 1.5 2.4 1 0 0 1 1 1 0 Phage shock protein B FlaC_arch PF05377.11 KOS22187.1 - 1.1 9.7 11.4 13 6.3 0.4 4.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF908 PF06012.12 KOS22188.1 - 3.7e-127 424.7 3.1 3.7e-127 424.7 3.1 4.8 7 0 0 7 7 7 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 KOS22188.1 - 6.7e-122 407.0 0.0 6.7e-122 407.0 0.0 7.7 9 1 0 9 9 9 2 Domain of Unknown Function (DUF913) HECT PF00632.25 KOS22188.1 - 7.9e-91 304.7 0.0 1.2e-90 304.1 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) UBM PF14377.6 KOS22188.1 - 1.1e-23 81.8 20.1 1.1e-08 34.2 5.2 4.0 3 0 0 3 3 3 3 Ubiquitin binding region UBA PF00627.31 KOS22188.1 - 0.0011 18.8 0.2 0.0037 17.1 0.2 2.0 1 0 0 1 1 1 1 UBA/TS-N domain Ribosomal_S6e PF01092.19 KOS22189.1 - 7.9e-59 197.1 0.1 1.5e-58 196.2 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S6e Haem_degrading PF03928.14 KOS22190.1 - 9.6e-32 109.5 0.3 1.3e-31 109.1 0.3 1.2 1 0 0 1 1 1 1 Haem-degrading LAMTOR PF15454.6 KOS22191.1 - 2.3e-07 31.3 0.0 3.2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Dynamin_N PF00350.23 KOS22192.1 - 9.7e-15 55.0 0.0 4.5e-14 52.9 0.0 2.1 1 1 0 1 1 1 1 Dynamin family Dynamin_M PF01031.20 KOS22192.1 - 4e-06 26.3 0.1 0.008 15.4 0.0 2.5 3 0 0 3 3 3 2 Dynamin central region GED PF02212.18 KOS22192.1 - 0.0013 18.9 0.1 0.0013 18.9 0.1 2.2 3 0 0 3 3 3 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 KOS22192.1 - 0.016 15.3 0.0 0.12 12.5 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase ABC_tran PF00005.27 KOS22192.1 - 0.019 15.5 0.0 0.044 14.3 0.0 1.6 1 0 0 1 1 1 0 ABC transporter HalX PF08663.10 KOS22192.1 - 0.36 11.2 3.7 0.69 10.3 1.2 2.6 2 0 0 2 2 2 0 HalX domain RRM_1 PF00076.22 KOS22193.1 - 6.9e-20 70.6 0.0 1.6e-09 37.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MRI PF15325.6 KOS22193.1 - 4.9 8.3 8.9 4.7 8.4 3.5 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection NTP_transferase PF00483.23 KOS22194.1 - 8.3e-33 114.0 0.0 1.1e-32 113.5 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase Hexapep PF00132.24 KOS22194.1 - 9.5e-10 37.8 8.4 2.4e-06 27.0 0.1 3.5 3 0 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 KOS22194.1 - 5.2e-07 30.1 0.0 7.7e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glycos_transf_2 PF00535.26 KOS22194.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 2 IspD PF01128.19 KOS22194.1 - 0.2 11.4 0.0 0.72 9.6 0.0 1.8 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Nuc_sug_transp PF04142.15 KOS22195.1 - 1.5e-80 270.8 6.2 5.2e-80 268.9 6.2 1.7 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 KOS22195.1 - 6.8e-06 26.3 25.1 0.00025 21.2 7.2 2.5 2 1 0 2 2 2 2 EamA-like transporter family UAA PF08449.11 KOS22195.1 - 9.4e-05 21.8 7.6 0.0012 18.1 7.6 2.2 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 KOS22195.1 - 0.76 8.9 15.2 0.88 8.7 1.0 2.9 2 1 0 2 2 2 0 Purine nucleobase transmembrane transport DUF4231 PF14015.6 KOS22195.1 - 1.5 9.3 4.3 14 6.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) TMEM234 PF10639.9 KOS22195.1 - 3.1 7.9 6.2 1.2 9.2 0.5 2.6 3 0 0 3 3 3 0 Putative transmembrane family 234 DUF677 PF05055.12 KOS22196.1 - 0.015 14.2 0.5 0.013 14.4 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) Vma12 PF11712.8 KOS22196.1 - 0.019 15.1 0.9 0.025 14.6 0.9 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase GAT PF03127.14 KOS22196.1 - 0.023 15.0 0.6 0.035 14.4 0.6 1.3 1 0 0 1 1 1 0 GAT domain Cytokin_check_N PF10407.9 KOS22196.1 - 0.067 13.2 0.9 0.29 11.1 0.1 2.0 2 0 0 2 2 2 0 Cdc14 phosphatase binding protein N-terminus FapA PF03961.13 KOS22196.1 - 0.24 10.0 2.2 0.25 9.9 2.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A RPEL PF02755.15 KOS22197.1 - 0.00081 19.0 0.3 0.018 14.7 0.3 2.4 2 0 0 2 2 2 1 RPEL repeat F-box PF00646.33 KOS22197.1 - 0.00096 19.0 3.4 0.0031 17.4 3.4 2.0 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 KOS22197.1 - 0.0025 17.7 0.6 0.007 16.2 0.6 1.8 1 0 0 1 1 1 1 F-box-like CysG_dimeriser PF10414.9 KOS22197.1 - 0.69 9.7 8.0 3 7.6 0.5 2.7 3 0 0 3 3 3 0 Sirohaem synthase dimerisation region Cep57_CLD_2 PF14197.6 KOS22198.1 - 0.42 10.7 7.8 0.82 9.8 7.8 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 CENP-Q PF13094.6 KOS22198.1 - 1.9 8.7 10.8 0.16 12.2 5.2 2.1 3 0 0 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit SOG2 PF10428.9 KOS22198.1 - 2.9 7.0 4.9 3.3 6.8 4.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3381 PF11861.8 KOS22198.1 - 6.1 6.6 10.5 1.8 8.3 7.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Med7 PF05983.11 KOS22199.1 - 4.7e-60 203.0 0.1 5.5e-60 202.7 0.1 1.0 1 0 0 1 1 1 1 MED7 protein MFS_1 PF07690.16 KOS22202.1 - 1.7e-17 63.4 72.8 9.8e-15 54.3 45.1 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily Spt20 PF12090.8 KOS22205.1 - 5.1e-05 23.0 9.5 7e-05 22.6 9.5 1.2 1 0 0 1 1 1 1 Spt20 family Presenilin PF01080.17 KOS22205.1 - 0.00026 19.9 2.5 0.00033 19.5 2.5 1.2 1 0 0 1 1 1 1 Presenilin RR_TM4-6 PF06459.12 KOS22205.1 - 0.00031 20.7 8.8 0.00042 20.3 8.8 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 SAPS PF04499.15 KOS22205.1 - 0.0015 17.4 0.2 0.0017 17.3 0.2 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Tim54 PF11711.8 KOS22205.1 - 0.0028 16.5 8.1 0.0037 16.1 8.1 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 KOS22205.1 - 0.0055 17.4 7.9 0.01 16.5 7.9 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region MMR1 PF08505.10 KOS22205.1 - 0.0056 17.0 4.4 0.0068 16.7 4.4 1.1 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein Neur_chan_memb PF02932.16 KOS22205.1 - 0.0076 16.3 0.4 0.0083 16.2 0.4 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 KOS22205.1 - 0.017 14.5 1.7 0.024 14.0 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 KOS22205.1 - 0.02 15.1 1.1 0.026 14.7 1.1 1.2 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 KOS22205.1 - 0.024 13.6 2.2 0.031 13.3 2.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GAGA_bind PF06217.12 KOS22205.1 - 0.035 14.4 5.3 0.042 14.1 5.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family NKAIN PF05640.14 KOS22205.1 - 0.1 11.9 0.1 0.17 11.1 0.1 1.3 1 0 0 1 1 1 0 Na,K-Atpase Interacting protein DUF2052 PF09747.9 KOS22205.1 - 0.12 12.5 12.5 0.17 12.0 12.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) LptF_LptG PF03739.14 KOS22205.1 - 0.12 11.1 0.1 0.17 10.7 0.1 1.1 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Serinc PF03348.15 KOS22205.1 - 0.13 11.2 0.1 0.15 11.0 0.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_pol_Rpc4 PF05132.14 KOS22205.1 - 0.18 12.2 10.6 0.3 11.5 10.6 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 KOS22205.1 - 0.21 10.5 0.6 0.3 10.0 0.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator ALMT PF11744.8 KOS22205.1 - 0.21 10.4 4.0 0.28 10.0 4.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ndc1_Nup PF09531.10 KOS22205.1 - 0.22 10.1 2.2 0.31 9.7 2.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Connexin PF00029.19 KOS22205.1 - 0.23 11.2 8.7 0.37 10.5 8.7 1.4 1 0 0 1 1 1 0 Connexin EMC3_TMCO1 PF01956.16 KOS22205.1 - 0.34 10.6 2.6 0.5 10.1 2.6 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like OATP PF03137.20 KOS22205.1 - 0.36 9.1 1.2 0.47 8.7 1.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family SpoIIP PF07454.11 KOS22205.1 - 0.39 10.1 11.3 0.51 9.8 11.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) eIF-3_zeta PF05091.12 KOS22205.1 - 0.39 9.6 11.3 0.5 9.3 11.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Endostatin PF06482.11 KOS22205.1 - 0.43 10.0 8.7 0.61 9.5 8.7 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CPSF100_C PF13299.6 KOS22205.1 - 0.44 10.7 9.8 0.63 10.2 9.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Band_3_cyto PF07565.13 KOS22205.1 - 0.66 9.7 6.6 0.88 9.3 6.6 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4746 PF15928.5 KOS22205.1 - 1.3 8.4 12.9 1.8 7.9 12.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TERB2 PF15101.6 KOS22205.1 - 1.4 8.9 11.7 2 8.4 11.7 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 SLC12 PF03522.15 KOS22205.1 - 1.5 7.7 10.5 2.3 7.1 10.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM176 PF14851.6 KOS22205.1 - 2 8.1 6.2 4.3 7.0 6.2 1.7 1 0 0 1 1 1 0 FAM176 family Asp-B-Hydro_N PF05279.11 KOS22205.1 - 2.1 8.3 15.4 2.9 7.9 15.4 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Paf1 PF03985.13 KOS22205.1 - 2.8 6.8 19.2 3.8 6.4 19.2 1.1 1 0 0 1 1 1 0 Paf1 CobT PF06213.12 KOS22205.1 - 3.8 6.8 17.4 5.7 6.2 17.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PAT1 PF09770.9 KOS22205.1 - 4.8 5.3 18.6 6.8 4.8 18.6 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 NARP1 PF12569.8 KOS22205.1 - 5.1 5.9 15.5 6.7 5.5 15.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Hid1 PF12722.7 KOS22205.1 - 7.6 4.5 11.3 9.8 4.2 11.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3408 PF11888.8 KOS22205.1 - 8.3 6.6 19.9 15 5.8 19.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Pyr_redox_2 PF07992.14 KOS22206.1 - 7.9e-15 54.8 0.4 1.4e-12 47.5 0.8 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS22206.1 - 2.1e-14 53.5 0.0 2.6e-10 40.1 0.0 2.9 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS22206.1 - 1.9e-10 40.4 0.0 5e-08 32.5 0.0 2.9 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) FMO-like PF00743.19 KOS22206.1 - 7.5e-10 37.8 0.0 4.8e-05 22.0 0.0 2.2 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 KOS22206.1 - 3.1e-07 30.5 0.2 3.1e-07 30.5 0.2 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOS22206.1 - 6.5e-06 26.6 7.8 0.019 15.5 0.8 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOS22206.1 - 3.4e-05 23.3 0.1 0.0055 16.0 0.0 2.5 3 0 0 3 3 3 1 Flavin containing amine oxidoreductase Shikimate_DH PF01488.20 KOS22206.1 - 3.9e-05 23.7 0.4 0.14 12.2 0.1 2.3 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase DAO PF01266.24 KOS22206.1 - 4.1e-05 23.3 11.4 6.8e-05 22.6 0.7 3.7 4 0 0 4 4 4 1 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KOS22206.1 - 0.00054 19.3 4.4 0.011 15.0 0.2 2.2 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 KOS22206.1 - 0.00075 19.9 0.3 0.014 15.8 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_9 PF13454.6 KOS22206.1 - 0.0041 17.1 8.0 0.014 15.4 0.4 3.8 3 1 1 4 4 4 1 FAD-NAD(P)-binding 3HCDH_N PF02737.18 KOS22206.1 - 0.028 14.3 1.0 0.047 13.6 1.0 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 KOS22206.1 - 0.22 10.2 4.6 0.5 9.0 0.8 2.5 3 0 0 3 3 3 0 HI0933-like protein Thi4 PF01946.17 KOS22206.1 - 2 7.6 4.7 0.95 8.7 0.5 2.2 2 0 0 2 2 2 0 Thi4 family Ank_2 PF12796.7 KOS22207.1 - 3.8e-34 117.1 0.1 2.2e-11 44.2 0.0 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) DHHC PF01529.20 KOS22207.1 - 3.5e-32 111.3 10.1 3.5e-32 111.3 10.1 2.8 3 0 0 3 3 3 1 DHHC palmitoyltransferase Ank_5 PF13857.6 KOS22207.1 - 2.4e-23 81.9 0.1 6.6e-08 32.7 0.0 4.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS22207.1 - 3.5e-23 79.2 1.7 3.7e-06 26.8 0.0 6.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 KOS22207.1 - 1.6e-22 79.5 0.4 7.9e-07 29.5 0.2 4.8 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 KOS22207.1 - 1.1e-21 76.2 0.5 0.00085 19.7 0.0 5.6 5 0 0 5 5 5 4 Ankyrin repeat TPR_17 PF13431.6 KOS22208.1 - 0.045 14.1 0.4 0.41 11.1 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22208.1 - 1.9 8.8 5.2 0.45 10.8 0.7 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Ribosomal_L27e PF01777.18 KOS22209.1 - 1.3e-36 124.8 4.5 1.9e-36 124.3 4.5 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 KOS22209.1 - 0.0053 16.7 0.9 0.017 15.1 0.9 1.9 1 0 0 1 1 1 1 KOW motif Ssl1 PF04056.14 KOS22210.1 - 6.5e-75 251.2 0.0 8.3e-75 250.8 0.0 1.1 1 0 0 1 1 1 1 Ssl1-like VWA_2 PF13519.6 KOS22210.1 - 3.3e-17 63.1 0.0 8.4e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 von Willebrand factor type A domain C1_4 PF07975.12 KOS22210.1 - 1.3e-15 57.3 2.9 1.3e-15 57.3 2.9 3.1 3 0 0 3 3 3 1 TFIIH C1-like domain VWA PF00092.28 KOS22210.1 - 0.0003 21.1 0.0 0.00041 20.7 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Glyoxalase PF00903.25 KOS22211.1 - 1.5e-20 73.7 0.1 6.1e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KOS22211.1 - 2.4e-11 43.9 0.1 3.3e-05 24.1 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 KOS22211.1 - 5.1e-06 26.7 0.0 0.069 13.3 0.0 3.1 3 0 0 3 3 3 2 Glyoxalase-like domain Glyoxalase_5 PF14696.6 KOS22211.1 - 0.015 15.4 0.1 0.048 13.8 0.1 1.8 2 0 0 2 2 2 0 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal Sugar_tr PF00083.24 KOS22212.1 - 2.4e-98 330.0 14.0 3.1e-98 329.6 14.0 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS22212.1 - 1e-26 93.7 22.7 1e-26 93.7 22.7 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.6 KOS22212.1 - 4.1e-09 35.5 16.7 6.4e-07 28.3 7.3 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein MFS_5 PF05631.14 KOS22212.1 - 0.0023 16.9 2.0 0.0045 16.0 2.0 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1_like PF12832.7 KOS22212.1 - 0.055 12.3 5.8 0.75 8.6 1.0 2.2 1 1 0 2 2 2 0 MFS_1 like family MFS_3 PF05977.13 KOS22212.1 - 0.08 11.3 4.9 0.25 9.7 0.7 2.1 2 0 0 2 2 2 0 Transmembrane secretion effector Chs7 PF12271.8 KOS22213.1 - 1.6e-97 326.4 9.6 1.4e-95 320.0 9.6 2.0 1 1 0 1 1 1 1 Chitin synthase export chaperone DUF1218 PF06749.12 KOS22213.1 - 7.2 7.2 9.7 0.76 10.3 0.2 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1218) Complex1_LYR PF05347.15 KOS22214.1 - 0.0006 19.8 0.1 0.01 15.8 0.2 2.3 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 KOS22214.1 - 0.014 16.0 2.6 0.85 10.3 0.8 2.3 1 1 1 2 2 2 0 Complex1_LYR-like Complex1_LYR_2 PF13233.6 KOS22214.1 - 0.042 14.6 0.7 0.074 13.8 0.7 1.8 1 1 0 1 1 1 0 Complex1_LYR-like TPT PF03151.16 KOS22216.1 - 1.2e-24 87.2 28.5 1.5e-24 86.9 28.5 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 KOS22216.1 - 0.00023 21.4 41.5 0.0072 16.5 13.8 2.7 3 0 0 3 3 3 2 EamA-like transporter family UAA PF08449.11 KOS22216.1 - 0.097 11.9 27.2 0.33 10.1 27.2 1.7 1 1 0 1 1 1 0 UAA transporter family Amino_oxidase PF01593.24 KOS22217.1 - 1.4e-08 34.4 0.0 5.6e-08 32.5 0.0 1.8 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS22217.1 - 1.6e-08 34.6 0.1 4e-08 33.4 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 KOS22217.1 - 0.0059 15.9 0.1 0.009 15.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 KOS22217.1 - 0.0073 15.6 0.1 0.012 14.9 0.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 KOS22217.1 - 0.025 13.8 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS22217.1 - 0.032 13.8 0.1 0.056 13.0 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Thi4 PF01946.17 KOS22217.1 - 0.037 13.3 0.0 0.068 12.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Lycopene_cycl PF05834.12 KOS22217.1 - 0.051 12.6 0.1 0.085 11.9 0.1 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 KOS22217.1 - 0.081 12.9 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 FAD-NAD(P)-binding FAD_oxidored PF12831.7 KOS22217.1 - 0.084 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS22217.1 - 0.15 11.1 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 KOS22217.1 - 0.17 10.6 0.0 0.24 10.0 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein RINGv PF12906.7 KOS22218.1 - 2.8e-16 59.4 6.8 5.2e-16 58.5 6.8 1.5 1 0 0 1 1 1 1 RING-variant domain zf-RING_2 PF13639.6 KOS22218.1 - 0.0077 16.5 7.9 0.015 15.7 7.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_4 PF14570.6 KOS22218.1 - 6.5 6.6 6.2 13 5.7 6.2 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain ABC_tran PF00005.27 KOS22220.1 - 7.1e-41 139.9 0.0 5.8e-26 91.6 0.0 2.4 2 0 0 2 2 2 2 ABC transporter ABC_membrane PF00664.23 KOS22220.1 - 2.1e-17 63.7 2.1 3.5e-13 49.8 0.0 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region SMC_N PF02463.19 KOS22220.1 - 5.1e-16 58.8 0.1 0.00041 19.8 0.0 4.9 5 0 0 5 5 5 4 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOS22220.1 - 7.1e-07 29.8 3.5 0.02 15.3 0.1 3.6 3 1 0 3 3 3 2 AAA ATPase domain AAA_29 PF13555.6 KOS22220.1 - 3.1e-06 26.8 0.1 0.035 13.8 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_21 PF13304.6 KOS22220.1 - 5.6e-05 23.1 0.5 0.79 9.5 0.0 4.1 4 0 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOS22220.1 - 6.5e-05 23.5 0.3 0.5 10.8 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 KOS22220.1 - 8.5e-05 22.8 0.0 0.18 12.1 0.0 2.8 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 KOS22220.1 - 0.00011 22.2 0.0 0.37 10.7 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Zeta_toxin PF06414.12 KOS22220.1 - 0.00093 18.5 0.1 0.54 9.5 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin MMR_HSR1 PF01926.23 KOS22220.1 - 0.0017 18.4 0.7 0.21 11.7 0.1 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase T2SSE PF00437.20 KOS22220.1 - 0.0032 16.6 0.2 1.4 7.9 0.1 2.5 2 0 0 2 2 2 2 Type II/IV secretion system protein Dynamin_N PF00350.23 KOS22220.1 - 0.016 15.2 0.0 1.2 9.1 0.0 2.3 2 0 0 2 2 2 0 Dynamin family DUF87 PF01935.17 KOS22220.1 - 0.017 15.2 0.6 0.039 14.0 0.6 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_25 PF13481.6 KOS22220.1 - 0.021 14.4 0.4 0.87 9.1 0.0 2.7 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 KOS22220.1 - 0.027 14.7 0.2 1.9 8.8 0.0 3.6 3 1 0 3 3 3 0 Putative exonuclease SbcCD, C subunit FtsK_SpoIIIE PF01580.18 KOS22220.1 - 0.032 13.6 0.1 0.17 11.2 0.0 2.1 2 0 0 2 2 2 0 FtsK/SpoIIIE family DUF2075 PF09848.9 KOS22220.1 - 0.051 12.8 0.1 6.7 5.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 KOS22220.1 - 0.053 13.4 0.4 11 5.9 0.0 3.0 3 0 0 3 3 3 0 NACHT domain Cyclin_N PF00134.23 KOS22220.1 - 0.12 12.2 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 Cyclin, N-terminal domain Viral_helicase1 PF01443.18 KOS22220.1 - 0.24 11.1 0.0 14 5.4 0.0 2.3 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 KOS22220.1 - 0.33 10.5 0.8 4.4 6.8 0.2 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Corona_nucleoca PF00937.18 KOS22221.1 - 0.39 9.7 2.1 0.55 9.2 2.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF3235 PF11574.8 KOS22222.1 - 0.01 16.7 4.9 1.5 9.8 1.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) AA_permease PF00324.21 KOS22223.1 - 1e-112 377.2 37.6 1.2e-112 376.9 37.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS22223.1 - 7.2e-21 74.5 41.1 9.3e-21 74.1 41.1 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1772 PF08592.11 KOS22223.1 - 0.0039 17.5 2.9 0.0039 17.5 2.9 4.0 3 1 1 4 4 4 1 Domain of unknown function (DUF1772) Aldedh PF00171.22 KOS22224.1 - 5.4e-149 496.6 0.0 6.6e-149 496.3 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PYNP_C PF07831.13 KOS22224.1 - 0.021 14.5 0.0 0.084 12.5 0.0 2.0 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain GMC_oxred_N PF00732.19 KOS22225.1 - 6.2e-52 176.8 0.0 8e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 KOS22225.1 - 3.4e-39 134.6 0.0 5.4e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 GMC oxidoreductase Lycopene_cycl PF05834.12 KOS22225.1 - 5.3e-05 22.4 0.0 8.1e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein NAD_binding_8 PF13450.6 KOS22225.1 - 0.00029 21.0 0.2 0.00083 19.5 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 KOS22225.1 - 0.00047 19.4 0.0 0.35 9.9 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 KOS22225.1 - 0.0017 18.0 0.9 0.021 14.4 0.1 2.7 3 0 0 3 3 3 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS22225.1 - 0.0094 15.2 0.0 0.059 12.6 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS22225.1 - 0.034 13.0 0.0 0.049 12.5 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase Ferric_reduct PF01794.19 KOS22226.1 - 2e-17 63.5 13.9 2e-17 63.5 13.9 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 KOS22226.1 - 2.8e-11 43.5 0.0 5.6e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 KOS22226.1 - 8.7e-07 29.2 0.0 2.2e-06 27.9 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain DUF4405 PF14358.6 KOS22226.1 - 0.011 16.3 2.0 0.011 16.3 2.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4405) Pox_A32 PF04665.12 KOS22226.1 - 0.26 10.7 0.1 0.54 9.7 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein KH_1 PF00013.29 KOS22227.1 - 0.15 11.9 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 KH domain RNA_POL_M_15KD PF02150.16 KOS22228.1 - 7.5e-12 44.9 2.4 7.5e-12 44.9 2.4 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Nudix_N_2 PF14803.6 KOS22228.1 - 0.03 14.2 8.9 0.15 12.0 1.0 2.9 3 0 0 3 3 3 0 Nudix N-terminal MFS_1 PF07690.16 KOS22229.1 - 3.4e-36 124.9 43.9 1.4e-34 119.6 42.3 2.4 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS22229.1 - 6.7e-15 54.9 13.9 6.7e-15 54.9 13.9 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 KOS22229.1 - 4.5e-11 41.9 20.8 5.8e-11 41.5 20.8 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HAUS-augmin3 PF14932.6 KOS22230.1 - 0.00019 21.1 4.9 0.00019 21.1 4.9 2.2 2 1 0 2 2 2 1 HAUS augmin-like complex subunit 3 Atg14 PF10186.9 KOS22230.1 - 0.0038 16.4 3.9 0.0089 15.1 3.9 1.6 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DDE_Tnp_IS1595 PF12762.7 KOS22230.1 - 0.036 14.1 0.5 0.086 12.8 0.1 1.8 2 0 0 2 2 2 0 ISXO2-like transposase domain DUF4795 PF16043.5 KOS22230.1 - 0.07 12.7 2.2 0.14 11.8 2.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) CLZ PF16526.5 KOS22230.1 - 0.1 13.0 5.1 2.7 8.4 0.1 4.0 3 2 1 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4200 PF13863.6 KOS22230.1 - 0.14 12.5 6.6 0.25 11.7 5.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Prefoldin PF02996.17 KOS22230.1 - 0.79 9.7 6.8 0.71 9.8 0.6 3.6 4 0 0 4 4 4 0 Prefoldin subunit LCE PF14672.6 KOS22230.1 - 4.1 8.1 7.0 3.8 8.2 1.8 2.3 2 0 0 2 2 2 0 Late cornified envelope p450 PF00067.22 KOS22231.1 - 8.8e-51 173.1 0.0 1.1e-50 172.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 G6PD_N PF00479.22 KOS22231.1 - 0.047 14.3 0.1 4.1 8.0 0.1 2.2 2 0 0 2 2 2 0 Glucose-6-phosphate dehydrogenase, NAD binding domain FSH1 PF03959.13 KOS22232.1 - 1.3e-16 60.9 0.0 2e-16 60.3 0.0 1.3 1 1 0 1 1 1 1 Serine hydrolase (FSH1) ketoacyl-synt PF00109.26 KOS22233.1 - 4.7e-64 216.4 0.0 3.9e-63 213.4 0.0 2.2 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 KOS22233.1 - 1.2e-53 181.7 0.0 2.8e-53 180.5 0.0 1.7 1 0 0 1 1 1 1 KR domain Acyl_transf_1 PF00698.21 KOS22233.1 - 3.1e-52 178.1 0.2 5.2e-52 177.3 0.2 1.3 1 0 0 1 1 1 1 Acyl transferase domain PS-DH PF14765.6 KOS22233.1 - 1.6e-44 152.3 0.0 3.5e-44 151.3 0.0 1.6 1 0 0 1 1 1 1 Polyketide synthase dehydratase Ketoacyl-synt_C PF02801.22 KOS22233.1 - 6.6e-40 135.8 0.0 1.4e-39 134.8 0.0 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_12 PF08242.12 KOS22233.1 - 2.2e-18 66.8 0.0 8.2e-18 65.0 0.0 2.1 2 0 0 2 2 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 KOS22233.1 - 4.1e-16 60.3 0.0 2e-14 54.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase KAsynt_C_assoc PF16197.5 KOS22233.1 - 6.3e-15 55.6 0.0 2.1e-13 50.7 0.0 2.7 1 1 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension ADH_zinc_N PF00107.26 KOS22233.1 - 2e-14 53.7 0.0 5.8e-14 52.2 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_23 PF13489.6 KOS22233.1 - 2.8e-12 46.8 0.0 7.9e-12 45.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22233.1 - 7e-11 42.6 0.0 5.8e-09 36.5 0.0 3.3 3 0 0 3 3 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22233.1 - 3.4e-09 37.3 0.0 2.9e-08 34.3 0.0 2.7 2 0 0 2 2 2 1 Methyltransferase domain adh_short PF00106.25 KOS22233.1 - 6.7e-09 35.5 0.0 2.2e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase PP-binding PF00550.25 KOS22233.1 - 1.8e-08 34.6 0.0 5.1e-08 33.2 0.0 1.8 1 0 0 1 1 1 1 Phosphopantetheine attachment site Methyltransf_31 PF13847.6 KOS22233.1 - 4.8e-08 32.9 0.0 1.2e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS22233.1 - 5e-05 22.8 0.0 9.1e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_28 PF02636.17 KOS22233.1 - 0.0026 17.5 0.0 0.0054 16.4 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase PALP PF00291.25 KOS22233.1 - 0.0034 16.8 2.9 1 8.7 0.1 3.3 3 0 0 3 3 3 1 Pyridoxal-phosphate dependent enzyme Thiolase_N PF00108.23 KOS22233.1 - 0.0081 15.6 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain ACP_syn_III PF08545.10 KOS22233.1 - 0.017 15.0 0.5 0.043 13.7 0.5 1.7 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Rotamase PF00639.21 KOS22234.1 - 3.2e-22 79.3 0.1 4.6e-22 78.8 0.1 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 KOS22234.1 - 3.9e-16 59.6 0.0 5.1e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 KOS22234.1 - 0.00017 22.4 0.0 0.00024 21.9 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 KOS22234.1 - 0.0011 19.0 0.7 0.0027 17.7 0.1 1.9 2 0 0 2 2 2 1 WW domain Pyridox_ox_2 PF12900.7 KOS22234.1 - 0.074 13.1 0.2 0.19 11.7 0.2 1.6 2 0 0 2 2 2 0 Pyridoxamine 5'-phosphate oxidase AAA PF00004.29 KOS22235.1 - 0.019 15.4 0.0 0.036 14.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS22235.1 - 0.057 13.7 0.1 0.46 10.7 0.1 2.4 2 1 1 3 3 3 0 AAA domain Torsin PF06309.11 KOS22235.1 - 0.077 13.1 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Torsin MukE PF04288.13 KOS22235.1 - 0.18 10.7 0.0 0.29 10.0 0.0 1.2 1 0 0 1 1 1 0 MukE-like family BCS1_N PF08740.11 KOS22236.1 - 2e-41 142.0 0.0 2.7e-41 141.6 0.0 1.2 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 KOS22236.1 - 1.2e-17 64.5 0.0 1.9e-17 63.9 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 KOS22236.1 - 0.00028 20.4 0.0 0.00048 19.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_16 PF13191.6 KOS22236.1 - 0.0018 18.7 0.0 0.0055 17.1 0.0 1.8 2 0 0 2 2 1 1 AAA ATPase domain AAA_25 PF13481.6 KOS22236.1 - 0.002 17.7 0.0 0.023 14.3 0.0 2.4 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 KOS22236.1 - 0.003 17.6 0.0 0.0065 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 KOS22236.1 - 0.0056 16.4 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_29 PF13555.6 KOS22236.1 - 0.0072 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 KOS22236.1 - 0.0094 16.5 0.0 0.016 15.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF815 PF05673.13 KOS22236.1 - 0.013 14.7 0.0 0.022 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 KOS22236.1 - 0.015 15.6 0.0 0.033 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOS22236.1 - 0.017 15.7 0.0 0.031 14.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 KOS22236.1 - 0.036 14.2 0.0 0.079 13.0 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 KOS22236.1 - 0.043 14.0 0.0 0.09 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS22236.1 - 0.048 13.6 0.0 3 7.7 0.0 2.4 2 0 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 KOS22236.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 KOS22236.1 - 0.12 12.8 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 RNA helicase IstB_IS21 PF01695.17 KOS22236.1 - 0.16 11.7 0.0 0.34 10.6 0.0 1.5 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_24 PF13479.6 KOS22236.1 - 0.19 11.4 0.0 1.1 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 KOS22236.1 - 0.2 12.1 0.0 0.47 10.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain PPV_E1_C PF00519.17 KOS22236.1 - 0.22 10.3 0.0 0.32 9.8 0.0 1.2 1 0 0 1 1 1 0 Papillomavirus helicase Rad17 PF03215.15 KOS22236.1 - 0.25 11.2 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain ATP_bind_1 PF03029.17 KOS22236.1 - 0.26 11.0 0.0 0.39 10.4 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein LrgB PF04172.16 KOS22237.1 - 3e-19 69.4 15.5 9.6e-12 44.9 5.9 2.2 2 0 0 2 2 2 2 LrgB-like family Oxysterol_BP PF01237.18 KOS22238.1 - 7.8e-61 206.0 1.2 6.3e-53 179.9 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein DUF1579 PF07617.11 KOS22238.1 - 0.1 12.5 0.0 3.2 7.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1579) F_bP_aldolase PF01116.20 KOS22239.1 - 1.4e-88 297.0 0.0 1.6e-88 296.9 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II AUDH_Cupin PF18637.1 KOS22240.1 - 1e-56 191.3 0.9 1.5e-56 190.8 0.9 1.3 1 0 0 1 1 1 1 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain PBP3 PF18056.1 KOS22240.1 - 7.1e-32 109.8 0.0 1.1e-31 109.1 0.0 1.3 1 0 0 1 1 1 1 Penicillin Binding Protein 3 Domain VCBS PF13517.6 KOS22240.1 - 2.7e-07 31.1 4.3 0.00027 21.4 1.2 4.1 3 0 0 3 3 3 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.23 KOS22240.1 - 4.9 7.4 7.1 0.78 9.9 2.1 2.4 2 0 0 2 2 2 0 FG-GAP repeat Glyco_hydro_31 PF01055.26 KOS22241.1 - 4.9e-92 309.4 1.9 9.1e-92 308.5 1.9 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOS22241.1 - 1.3e-08 35.0 0.7 3.7e-08 33.6 0.7 1.9 1 0 0 1 1 1 1 Galactose mutarotase-like DUF5110 PF17137.4 KOS22241.1 - 0.0017 18.6 0.0 0.0056 16.9 0.0 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF5110) CFEM PF05730.11 KOS22242.1 - 1.7e-11 44.1 7.1 2.4e-11 43.6 7.1 1.2 1 0 0 1 1 1 1 CFEM domain Ribosomal_L14 PF00238.19 KOS22243.1 - 2.1e-46 156.9 2.1 2.5e-46 156.7 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e NARP1 PF12569.8 KOS22244.1 - 4.9e-194 646.0 26.7 3.2e-192 640.0 22.0 2.3 2 0 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_19 PF14559.6 KOS22244.1 - 8.6e-21 74.2 41.4 0.00019 21.9 0.1 8.4 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_16 PF13432.6 KOS22244.1 - 4.4e-17 62.4 36.1 0.0009 19.8 0.2 9.7 8 2 2 10 10 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22244.1 - 5.8e-16 57.3 25.7 5e-05 23.1 0.2 10.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 KOS22244.1 - 1.3e-13 50.5 31.5 0.00097 19.8 0.1 11.0 8 4 5 13 13 11 4 Tetratricopeptide repeat TPR_9 PF13371.6 KOS22244.1 - 3.2e-13 49.6 7.2 9.8e-05 22.4 0.2 6.8 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOS22244.1 - 1.9e-10 40.1 25.4 5.4e-06 26.0 0.3 8.5 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOS22244.1 - 3e-10 39.7 7.7 0.039 14.3 0.0 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS22244.1 - 3.4e-10 40.0 16.4 0.00029 21.0 0.8 5.1 4 1 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 KOS22244.1 - 3.7e-10 39.3 15.8 2.5e-06 27.0 0.2 6.5 7 0 0 7 7 7 2 TPR repeat TPR_12 PF13424.6 KOS22244.1 - 1.5e-08 34.8 26.7 0.24 11.7 0.1 8.0 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22244.1 - 3e-07 30.1 19.6 0.00038 20.5 0.1 8.2 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_4 PF07721.14 KOS22244.1 - 6.9e-05 23.1 2.4 0.29 11.9 0.0 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 KOS22244.1 - 0.051 13.6 5.7 0.84 9.7 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF913 PF06025.12 KOS22244.1 - 0.11 11.5 0.2 0.18 10.7 0.2 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TPR_7 PF13176.6 KOS22244.1 - 0.15 12.2 17.8 46 4.4 0.0 7.8 7 0 0 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOS22244.1 - 3.4 7.8 11.7 8.3 6.6 0.0 5.5 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat Cid2 PF09774.9 KOS22245.1 - 1.3e-24 87.4 0.1 1.6e-24 87.2 0.1 1.0 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Mg-por_mtran_C PF07109.11 KOS22245.1 - 0.058 13.8 0.0 0.083 13.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium-protoporphyrin IX methyltransferase C-terminus Cir_N PF10197.9 KOS22247.1 - 4.7e-08 33.1 1.8 4.7e-08 33.1 1.8 3.4 3 0 0 3 3 3 1 N-terminal domain of CBF1 interacting co-repressor CIR CWC25 PF12542.8 KOS22247.1 - 0.1 13.5 5.8 0.39 11.6 3.2 2.6 2 1 0 2 2 2 0 Pre-mRNA splicing factor AAA PF00004.29 KOS22248.1 - 9.1e-51 171.7 0.0 1.5e-38 132.2 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS22248.1 - 2.7e-11 43.9 0.0 0.00023 21.4 0.0 3.8 2 2 0 2 2 2 2 AAA domain TIP49 PF06068.13 KOS22248.1 - 7.4e-11 41.8 0.0 1.3e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_lid_3 PF17862.1 KOS22248.1 - 2.2e-10 40.2 0.1 7.1e-10 38.5 0.1 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 KOS22248.1 - 2.3e-10 41.1 0.1 0.00045 20.6 0.0 2.9 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 KOS22248.1 - 1.6e-07 31.4 0.0 0.00089 19.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 KOS22248.1 - 2.8e-07 30.6 0.0 0.004 17.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 KOS22248.1 - 4.4e-07 30.1 0.0 0.033 14.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 KOS22248.1 - 1.3e-06 28.2 0.2 0.075 12.8 0.1 3.0 2 1 1 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 KOS22248.1 - 1.9e-06 28.1 0.0 0.00059 20.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 KOS22248.1 - 2.7e-06 27.1 0.2 0.00018 21.2 0.0 2.7 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 IstB_IS21 PF01695.17 KOS22248.1 - 3.9e-06 26.7 0.0 0.086 12.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein RNA_helicase PF00910.22 KOS22248.1 - 5.9e-06 26.6 0.0 0.06 13.7 0.0 2.7 2 0 0 2 2 2 2 RNA helicase NACHT PF05729.12 KOS22248.1 - 7.4e-06 26.0 0.2 0.038 13.9 0.0 3.4 4 0 0 4 4 3 1 NACHT domain AAA_18 PF13238.6 KOS22248.1 - 8.6e-06 26.3 0.0 0.14 12.7 0.0 3.1 3 0 0 3 3 3 2 AAA domain AAA_24 PF13479.6 KOS22248.1 - 1.8e-05 24.5 0.1 0.033 13.9 0.0 2.7 2 1 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 KOS22248.1 - 2e-05 24.6 0.4 8.7 6.2 0.0 4.1 2 2 2 4 4 4 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 KOS22248.1 - 2.6e-05 23.7 0.5 0.018 14.4 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 KOS22248.1 - 2.8e-05 23.7 0.4 0.11 12.0 0.0 2.9 4 0 0 4 4 2 2 P-loop containing dynein motor region Bac_DnaA PF00308.18 KOS22248.1 - 4.2e-05 23.5 0.0 0.014 15.2 0.0 2.7 3 0 0 3 3 2 1 Bacterial dnaA protein NB-ARC PF00931.22 KOS22248.1 - 7.9e-05 22.0 0.2 0.078 12.1 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain TsaE PF02367.17 KOS22248.1 - 0.00011 22.2 0.0 0.29 11.1 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 KOS22248.1 - 0.00016 22.2 0.2 0.8 10.2 0.1 2.4 2 0 0 2 2 2 2 ABC transporter Sigma54_activat PF00158.26 KOS22248.1 - 0.00022 21.0 0.0 0.51 10.0 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain PhoH PF02562.16 KOS22248.1 - 0.00074 19.0 0.0 0.53 9.7 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein ATPase PF06745.13 KOS22248.1 - 0.00094 18.6 1.7 0.031 13.6 0.2 2.8 3 0 0 3 3 3 1 KaiC AAA_28 PF13521.6 KOS22248.1 - 0.0018 18.5 0.0 1.6 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 KOS22248.1 - 0.0019 18.2 0.0 2.3 8.2 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_25 PF13481.6 KOS22248.1 - 0.0027 17.3 0.5 2.2 7.8 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_17 PF13207.6 KOS22248.1 - 0.0029 18.0 0.0 2 8.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 KOS22248.1 - 0.0031 16.7 0.0 0.48 9.5 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 DNA_pol3_delta2 PF13177.6 KOS22248.1 - 0.0042 16.9 0.1 2.7 7.8 0.0 3.9 3 2 1 4 4 4 1 DNA polymerase III, delta subunit Torsin PF06309.11 KOS22248.1 - 0.0047 17.0 0.0 0.34 11.0 0.0 2.4 2 0 0 2 2 2 1 Torsin AAA_29 PF13555.6 KOS22248.1 - 0.0049 16.6 0.2 1.2 9.0 0.0 3.3 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_30 PF13604.6 KOS22248.1 - 0.0054 16.5 0.0 0.36 10.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 KOS22248.1 - 0.006 15.9 0.2 0.82 8.8 0.1 2.4 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 KOS22248.1 - 0.017 14.9 0.0 1.1 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOS22248.1 - 0.019 15.4 0.0 3.3 8.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 KOS22248.1 - 0.027 14.2 0.1 3.8 7.2 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase AAA_19 PF13245.6 KOS22248.1 - 0.034 14.5 0.0 1.7 9.0 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_3 PF07726.11 KOS22248.1 - 0.035 14.0 0.0 0.75 9.7 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 KOS22248.1 - 0.054 12.9 0.1 12 5.3 0.0 3.0 2 1 0 3 3 3 0 Bacterial TniB protein Rad17 PF03215.15 KOS22248.1 - 0.18 11.7 0.0 5.4 6.9 0.0 2.6 3 0 0 3 3 2 0 Rad17 P-loop domain DAP3 PF10236.9 KOS22248.1 - 0.2 10.8 0.0 5.3 6.1 0.0 2.5 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 GDC-P PF02347.16 KOS22248.1 - 0.46 9.3 2.7 0.8 8.5 2.7 1.3 1 0 0 1 1 1 0 Glycine cleavage system P-protein SGP PF17228.2 KOS22248.1 - 0.47 11.3 12.4 1.3 9.9 12.4 1.7 1 0 0 1 1 1 0 Sulphur globule protein ANAPC10 PF03256.16 KOS22249.1 - 1.5e-31 109.5 0.0 2.8e-31 108.6 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) Asp PF00026.23 KOS22250.1 - 4.6e-55 187.2 0.0 5.4e-55 187.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS22250.1 - 1.6e-08 35.0 0.1 1.4e-06 28.7 0.0 2.7 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 KOS22250.1 - 0.00036 20.4 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 KOS22250.1 - 0.015 15.9 0.0 3.5 8.3 0.0 3.0 2 1 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 KOS22250.1 - 0.21 12.2 0.0 15 6.3 0.0 2.9 2 1 0 2 2 2 0 gag-polyprotein putative aspartyl protease Nop PF01798.18 KOS22251.1 - 1.5e-79 266.7 0.1 1.5e-79 266.7 0.1 2.0 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 KOS22251.1 - 2.2e-21 76.0 0.9 9.1e-21 74.0 0.9 2.2 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Phage_TAC_12 PF12363.8 KOS22251.1 - 0.043 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC Band_7 PF01145.25 KOS22252.1 - 2.6e-27 96.0 2.0 4.1e-27 95.3 2.0 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_C PF16200.5 KOS22252.1 - 0.045 13.8 0.8 0.4 10.8 0.2 2.8 3 0 0 3 3 3 0 C-terminal region of band_7 Band_7_1 PF13421.6 KOS22252.1 - 0.055 13.2 0.1 0.089 12.5 0.1 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family Ribosomal_S15 PF00312.22 KOS22253.1 - 7.2e-25 87.0 7.6 1.8e-24 85.7 0.7 3.0 2 1 1 3 3 3 1 Ribosomal protein S15 LMBR1 PF04791.16 KOS22253.1 - 0.015 14.2 1.1 0.023 13.6 1.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1460 PF07313.12 KOS22253.1 - 0.22 10.9 0.9 0.69 9.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1460) vATP-synt_AC39 PF01992.16 KOS22254.1 - 6.4e-105 351.4 0.0 7.1e-105 351.2 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit RasGEF_N PF00618.20 KOS22255.1 - 6.9e-13 48.7 1.2 2.6e-12 46.9 1.2 2.1 1 1 0 1 1 1 1 RasGEF N-terminal motif SR-25 PF10500.9 KOS22255.1 - 0.4 10.2 13.6 0.037 13.7 7.9 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 KOS22255.1 - 8 6.8 13.8 17 5.7 13.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Ribosomal_S2 PF00318.20 KOS22256.1 - 4.5e-25 88.1 0.1 1.6e-14 53.7 0.1 2.1 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 KOS22256.1 - 2.4e-06 28.8 15.4 4e-06 28.1 15.4 1.4 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus DAGK_cat PF00781.24 KOS22257.1 - 2.7e-25 88.4 0.0 3.8e-25 88.0 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Phosphoesterase PF04185.14 KOS22258.1 - 1.2e-51 176.0 7.8 2.4e-51 175.0 7.8 1.4 1 1 0 1 1 1 1 Phosphoesterase family DUF4932 PF16286.5 KOS22258.1 - 0.093 12.0 2.9 0.045 13.0 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4932) GDC-P PF02347.16 KOS22258.1 - 0.14 11.0 0.0 0.2 10.4 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein dCMP_cyt_deam_1 PF00383.23 KOS22259.1 - 9e-16 57.6 0.0 2.1e-15 56.4 0.0 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOS22259.1 - 5.3e-12 45.7 0.0 7.5e-06 25.7 0.0 2.3 2 0 0 2 2 2 2 MafB19-like deaminase Bd3614-deam PF14439.6 KOS22259.1 - 0.084 12.9 0.4 0.084 12.9 0.4 3.3 2 2 0 2 2 2 0 Bd3614-like deaminase DNA_pol_phi PF04931.13 KOS22259.1 - 8.9 4.3 26.4 14 3.6 26.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi TRAM_LAG1_CLN8 PF03798.16 KOS22260.1 - 2.9e-42 144.6 18.7 2.9e-42 144.6 18.7 2.0 2 0 0 2 2 2 1 TLC domain TRAM1 PF08390.11 KOS22260.1 - 7.9e-19 67.1 1.1 7.9e-19 67.1 1.1 2.4 2 0 0 2 2 2 1 TRAM1-like protein SLT PF01464.20 KOS22261.1 - 0.0012 18.5 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Transglycosylase SLT domain URO-D PF01208.17 KOS22261.1 - 0.22 10.6 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) MFS_1 PF07690.16 KOS22262.1 - 7.5e-30 104.0 22.8 1.3e-29 103.2 21.8 1.8 1 1 1 2 2 2 1 Major Facilitator Superfamily HhH-GPD PF00730.25 KOS22262.1 - 1.7e-16 60.6 0.0 3.8e-16 59.5 0.0 1.6 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein NUDIX_4 PF14815.6 KOS22262.1 - 2.7e-14 53.1 0.0 5.6e-14 52.1 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain HHH PF00633.23 KOS22262.1 - 0.012 15.5 0.0 0.03 14.2 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif MFS_1_like PF12832.7 KOS22262.1 - 0.014 14.3 5.3 0.04 12.8 5.3 1.8 1 1 0 1 1 1 0 MFS_1 like family OATP PF03137.20 KOS22262.1 - 0.31 9.3 9.4 0.034 12.4 1.0 2.8 2 1 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3446 PF11928.8 KOS22262.1 - 1.1 9.6 11.3 0.23 11.8 6.5 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain BSP_II PF05432.11 KOS22262.1 - 2 8.0 12.4 3.6 7.2 12.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Cofilin_ADF PF00241.20 KOS22263.1 - 4.1e-24 84.7 0.1 4.8e-24 84.5 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein AA_permease_2 PF13520.6 KOS22264.1 - 9e-49 166.4 52.1 1.1e-48 166.1 52.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS22264.1 - 2.1e-29 102.5 46.7 3.2e-29 101.9 46.7 1.2 1 0 0 1 1 1 1 Amino acid permease GAPT PF11770.8 KOS22264.1 - 0.28 11.0 0.1 1.1 9.1 0.1 2.0 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) CBM_21 PF03370.13 KOS22265.1 - 2.6e-33 114.6 1.0 4.9e-33 113.7 1.0 1.5 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 KOS22265.1 - 9.2e-09 35.8 0.3 2.1e-08 34.6 0.3 1.6 1 0 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) PX PF00787.24 KOS22266.1 - 1.9e-23 82.6 0.0 2.9e-23 82.0 0.0 1.3 1 0 0 1 1 1 1 PX domain Pkinase PF00069.25 KOS22267.1 - 2.7e-27 95.8 0.0 3.1e-27 95.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22267.1 - 7.6e-18 64.7 0.0 8.7e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS22267.1 - 0.0019 17.1 0.0 0.0034 16.2 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase DUF3328 PF11807.8 KOS22268.1 - 5.9e-45 153.7 0.1 7.5e-45 153.4 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) NusG PF02357.19 KOS22269.1 - 7e-06 26.5 0.0 2.4 8.7 0.0 5.9 1 1 0 1 1 1 1 Transcription termination factor nusG Tudor_3 PF18115.1 KOS22269.1 - 0.074 12.9 2.7 2.2e+02 1.8 0.0 5.2 1 1 7 8 8 8 0 DNA repair protein Crb2 Tudor domain EloA-BP1 PF15870.5 KOS22269.1 - 0.67 10.2 8.6 80 3.4 0.2 5.2 1 1 4 5 5 5 0 ElonginA binding-protein 1 adh_short PF00106.25 KOS22270.1 - 1.7e-50 171.2 3.7 2.5e-50 170.7 3.7 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS22270.1 - 6e-40 137.3 4.9 8.8e-40 136.7 4.9 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS22270.1 - 2.4e-14 53.6 3.8 3.4e-14 53.2 3.8 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 KOS22270.1 - 7.6e-07 29.2 2.3 1e-06 28.8 2.3 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOS22270.1 - 3.9e-05 23.2 0.9 0.00072 19.1 0.9 2.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOS22270.1 - 0.00083 18.6 0.3 0.0014 17.8 0.3 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein THF_DHG_CYH_C PF02882.19 KOS22270.1 - 0.0023 17.3 0.2 0.0054 16.1 0.2 1.6 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain DFP PF04127.15 KOS22270.1 - 0.0031 17.4 1.6 0.0061 16.4 1.6 1.4 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 KOS22270.1 - 0.019 14.5 3.2 0.26 10.8 2.3 2.2 2 0 0 2 2 2 0 NmrA-like family DUF460 PF04312.13 KOS22270.1 - 0.027 14.2 0.7 0.058 13.1 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF460) ApbA PF02558.16 KOS22270.1 - 0.047 13.3 0.1 0.095 12.3 0.1 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA AMP-binding PF00501.28 KOS22271.1 - 5.2e-70 236.2 0.0 9.1e-70 235.4 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme NAD_binding_4 PF07993.12 KOS22271.1 - 4.1e-61 206.4 0.0 5.7e-61 205.9 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein PP-binding PF00550.25 KOS22271.1 - 8.2e-13 48.5 0.0 2.1e-12 47.2 0.0 1.7 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 KOS22271.1 - 8.6e-11 41.8 0.0 2.3e-10 40.3 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOS22271.1 - 2e-06 27.1 0.2 1.3e-05 24.4 0.1 2.4 2 1 0 2 2 2 1 RmlD substrate binding domain AMP-binding_C PF13193.6 KOS22271.1 - 0.00022 22.2 2.1 0.00033 21.6 0.3 2.4 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain 3Beta_HSD PF01073.19 KOS22271.1 - 0.00029 19.9 0.0 0.0026 16.8 0.0 2.0 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family DUF3328 PF11807.8 KOS22272.1 - 1.1e-22 80.9 0.0 1.3e-22 80.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) DUF3328 PF11807.8 KOS22273.1 - 9.1e-11 41.9 0.5 1.6e-10 41.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3328) PRTP PF01366.18 KOS22274.1 - 0.055 11.5 0.0 0.079 11.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein RdRP PF05183.12 KOS22276.1 - 2.2e-57 195.0 0.0 4.3e-57 194.1 0.0 1.4 1 1 0 1 1 1 1 RNA dependent RNA polymerase zf-C3HC4_3 PF13920.6 KOS22277.1 - 0.013 15.4 7.5 0.03 14.2 7.5 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS22277.1 - 0.023 14.7 10.0 0.2 11.7 8.9 2.3 1 1 0 1 1 1 0 zinc-RING finger domain Prok-RING_4 PF14447.6 KOS22277.1 - 0.03 14.2 7.7 0.11 12.3 7.5 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 FYVE_2 PF02318.16 KOS22277.1 - 0.069 13.4 0.3 0.1 12.8 0.3 1.4 1 1 0 1 1 1 0 FYVE-type zinc finger zf-RING_2 PF13639.6 KOS22277.1 - 0.17 12.2 6.6 0.33 11.3 6.2 1.7 1 1 0 1 1 1 0 Ring finger domain SBP56 PF05694.11 KOS22277.1 - 0.21 10.4 0.1 0.22 10.3 0.1 1.1 1 0 0 1 1 1 0 56kDa selenium binding protein (SBP56) zf-C3HC4_4 PF15227.6 KOS22277.1 - 0.64 10.2 10.2 0.56 10.4 1.6 2.5 2 1 1 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 KOS22277.1 - 1.9 8.6 13.7 2.9 8.0 11.0 2.4 2 1 1 3 3 3 0 RING-type zinc-finger FYVE PF01363.21 KOS22277.1 - 2.3 8.4 8.1 5.4 7.2 8.2 1.7 1 1 0 1 1 1 0 FYVE zinc finger tRNA_U5-meth_tr PF05958.11 KOS22278.1 - 2.9e-13 49.6 0.0 5.7e-12 45.3 0.0 2.2 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_15 PF09445.10 KOS22278.1 - 9.1e-09 35.1 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_31 PF13847.6 KOS22278.1 - 1.3e-06 28.2 0.0 2.7e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22278.1 - 2e-05 25.2 0.0 5e-05 23.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain TRAM PF01938.20 KOS22278.1 - 0.00016 21.6 0.1 0.00039 20.4 0.1 1.6 1 0 0 1 1 1 1 TRAM domain Methyltransf_11 PF08241.12 KOS22278.1 - 0.0048 17.5 0.0 0.024 15.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 KOS22278.1 - 0.0098 15.5 0.0 0.018 14.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 KOS22278.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain PrmA PF06325.13 KOS22278.1 - 0.034 13.5 0.1 0.053 12.9 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_12 PF08242.12 KOS22278.1 - 0.12 13.1 0.0 0.27 12.0 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain G_glu_transpept PF01019.21 KOS22279.1 - 4.5e-164 547.0 0.0 5.2e-164 546.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase ALG11_N PF15924.5 KOS22280.1 - 1e-78 264.2 0.0 1.5e-78 263.7 0.0 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 KOS22280.1 - 1.6e-22 79.9 0.0 3e-22 78.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 KOS22280.1 - 2.5e-13 50.6 0.0 5.1e-13 49.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOS22280.1 - 2.7e-05 24.3 0.6 4.3e-05 23.6 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Gag_p12 PF01141.18 KOS22280.1 - 0.066 13.5 0.0 0.066 13.5 0.0 2.2 3 0 0 3 3 3 0 Gag polyprotein, inner coat protein p12 Pribosyl_synth PF14572.6 KOS22281.1 - 2.5e-44 151.5 2.2 3e-38 131.7 0.6 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 KOS22281.1 - 3.3e-30 104.4 0.0 7.6e-30 103.2 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 KOS22281.1 - 3.1e-13 49.6 0.2 5.2e-13 48.8 0.2 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Actin PF00022.19 KOS22282.1 - 1.6e-84 283.9 0.0 5.3e-50 170.2 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 KOS22282.1 - 0.012 14.4 0.0 3.1 6.5 0.0 2.2 2 0 0 2 2 2 0 MreB/Mbl protein Asparaginase_2 PF01112.18 KOS22283.1 - 3.1e-14 52.7 3.9 4.4e-14 52.2 3.9 1.3 1 0 0 1 1 1 1 Asparaginase Tfb4 PF03850.14 KOS22284.1 - 2.2e-93 312.7 0.2 2.8e-93 312.4 0.2 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 UNC45-central PF11701.8 KOS22285.1 - 1.7e-55 187.1 0.1 2.4e-53 180.2 0.0 3.1 3 0 0 3 3 3 2 Myosin-binding striated muscle assembly central HEAT_2 PF13646.6 KOS22285.1 - 0.0088 16.4 13.2 0.086 13.2 0.4 6.1 5 1 2 7 7 7 1 HEAT repeats HMA PF00403.26 KOS22286.1 - 9.9e-13 48.3 1.5 2e-12 47.3 0.4 1.8 1 1 1 2 2 2 1 Heavy-metal-associated domain Fer2_BFD PF04324.15 KOS22286.1 - 0.064 13.6 0.1 0.28 11.6 0.0 2.0 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain SLS PF14611.6 KOS22286.1 - 0.11 12.3 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Tox-PL-2 PF15643.6 KOS22286.1 - 0.12 12.6 0.0 0.13 12.4 0.0 1.1 1 0 0 1 1 1 0 Papain fold toxin 2 Thiolase_N PF00108.23 KOS22287.1 - 3.3e-13 49.6 0.3 1.2e-11 44.4 0.2 2.7 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS22287.1 - 8.7e-11 41.5 0.1 8.7e-11 41.5 0.1 2.8 2 1 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 KOS22287.1 - 0.00016 21.4 0.1 0.013 15.4 0.0 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Ketoacyl-synt_C PF02801.22 KOS22287.1 - 0.0005 20.1 1.0 0.088 12.8 0.0 3.4 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Methyltransf_23 PF13489.6 KOS22288.1 - 7.1e-12 45.5 0.0 1.7e-11 44.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22288.1 - 7.5e-10 39.3 0.1 3e-09 37.4 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22288.1 - 1e-09 39.0 0.0 3e-09 37.4 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22288.1 - 8.9e-09 36.0 0.0 1.4e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS22288.1 - 1.9e-08 34.0 0.0 4e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 KOS22288.1 - 1.7e-07 31.2 0.0 3.7e-07 30.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS22288.1 - 0.04 13.9 0.0 0.068 13.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain KRTAP PF11759.8 KOS22288.1 - 0.056 14.0 4.9 0.056 14.0 4.9 1.9 2 0 0 2 2 2 0 Keratin-associated matrix MTS PF05175.14 KOS22288.1 - 0.11 12.1 0.0 0.24 11.0 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase small domain Arg_decarbox_C PF17944.1 KOS22288.1 - 0.18 12.4 0.0 0.49 11.0 0.0 1.6 1 0 0 1 1 1 0 Arginine decarboxylase C-terminal helical extension PCMT PF01135.19 KOS22288.1 - 0.21 11.3 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SelP_N PF04592.14 KOS22288.1 - 6.6 6.1 9.2 9.7 5.5 9.2 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Acetyltransf_1 PF00583.25 KOS22289.1 - 3e-11 43.6 0.0 3.8e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOS22289.1 - 1.6e-07 31.7 0.1 2.3e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS22289.1 - 9.2e-07 28.8 0.1 1.3e-06 28.4 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pan3_PK PF18101.1 KOS22290.1 - 1.9e-64 215.8 0.1 2.9e-64 215.2 0.1 1.3 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 KOS22290.1 - 6.9e-05 22.3 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain UBA_4 PF14555.6 KOS22291.1 - 1e-08 34.8 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 KOS22291.1 - 1.1e-06 28.7 0.0 2.2e-06 27.8 0.0 1.5 1 0 0 1 1 1 1 UBX domain Rod_cone_degen PF15201.6 KOS22291.1 - 0.045 13.9 0.6 0.2 11.8 0.6 2.1 2 0 0 2 2 2 0 Progressive rod-cone degeneration WPP PF13943.6 KOS22291.1 - 0.17 12.3 0.0 0.17 12.3 0.0 2.5 1 1 1 2 2 2 0 WPP domain Pox_F11 PF04943.12 KOS22291.1 - 1.1 8.2 2.1 2.1 7.3 2.1 1.3 1 0 0 1 1 1 0 Poxvirus F11 protein Zn_clus PF00172.18 KOS22292.1 - 0.0043 17.2 10.8 0.0073 16.4 10.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain LSM PF01423.22 KOS22293.1 - 2e-20 72.2 0.3 2.4e-20 72.0 0.3 1.1 1 0 0 1 1 1 1 LSM domain FoP_duplication PF13865.6 KOS22293.1 - 0.97 10.0 18.7 1 9.9 18.0 1.4 1 1 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Peptidase_M43 PF05572.13 KOS22294.1 - 2.1e-16 60.2 0.0 3.5e-16 59.5 0.0 1.3 1 0 0 1 1 1 1 Pregnancy-associated plasma protein-A Reprolysin_5 PF13688.6 KOS22294.1 - 0.01 16.0 0.3 0.018 15.2 0.3 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 KOS22294.1 - 0.016 15.1 0.3 0.049 13.5 0.4 1.4 1 1 0 1 1 1 0 Matrixin Reprolysin_4 PF13583.6 KOS22294.1 - 0.024 14.3 0.1 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 KOS22294.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 KOS22294.1 - 0.12 11.6 0.2 0.2 10.8 0.2 1.3 1 0 0 1 1 1 0 Met-zincin Mito_carr PF00153.27 KOS22295.1 - 3.2e-74 244.9 1.2 6e-25 87.0 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOS22295.1 - 0.0044 16.2 0.2 2 7.5 0.0 2.8 2 1 0 2 2 2 2 Gammaproteobacterial serine protease UPRTase PF14681.6 KOS22296.1 - 1.9e-29 102.6 0.1 3.5e-29 101.7 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_17 PF13207.6 KOS22296.1 - 9.4e-15 55.2 0.0 3e-14 53.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain HAD PF12710.7 KOS22296.1 - 9.5e-08 32.7 0.0 2.3e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Pribosyltran PF00156.27 KOS22296.1 - 3.7e-06 26.5 2.2 4.8e-05 22.9 2.2 2.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Hydrolase_3 PF08282.12 KOS22296.1 - 0.0033 17.2 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AAA_18 PF13238.6 KOS22296.1 - 0.0041 17.7 0.0 0.0088 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Hydrolase PF00702.26 KOS22296.1 - 0.0075 16.6 0.0 0.029 14.6 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase PRTase_2 PF15609.6 KOS22296.1 - 0.044 13.3 0.1 0.091 12.3 0.1 1.6 1 1 0 1 1 1 0 Phosphoribosyl transferase AAA_33 PF13671.6 KOS22296.1 - 0.052 13.7 0.3 0.56 10.4 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.6 KOS22296.1 - 0.1 12.3 0.3 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain F-box PF00646.33 KOS22297.1 - 0.06 13.2 0.3 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 F-box domain CoA_transf_3 PF02515.17 KOS22298.1 - 7.8e-45 153.6 9.4 8.1e-44 150.2 4.6 2.9 3 0 0 3 3 3 2 CoA-transferase family III Robl_LC7 PF03259.17 KOS22298.1 - 1.3 8.8 4.8 7.9 6.3 0.3 3.0 3 0 0 3 3 3 0 Roadblock/LC7 domain MFS_1 PF07690.16 KOS22299.1 - 0.00014 20.9 5.9 0.00014 20.9 5.9 1.7 2 0 0 2 2 2 1 Major Facilitator Superfamily DUF5504 PF17608.2 KOS22299.1 - 0.083 13.0 0.5 0.17 12.0 0.3 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5504) A-2_8-polyST PF07388.11 KOS22299.1 - 0.18 10.4 0.0 0.27 9.8 0.0 1.3 1 1 0 1 1 1 0 Alpha-2,8-polysialyltransferase (POLYST) MIOX PF05153.15 KOS22300.1 - 8.3e-115 382.6 0.0 1.2e-114 382.1 0.0 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase Cytochrom_C_2 PF01322.20 KOS22300.1 - 0.02 15.7 0.7 0.03 15.2 0.7 1.3 1 0 0 1 1 1 0 Cytochrome C' HD_6 PF18019.1 KOS22300.1 - 0.084 13.0 0.1 0.15 12.2 0.0 1.5 2 0 0 2 2 2 0 HD domain DUF953 PF06110.11 KOS22301.1 - 1.2e-10 41.0 0.0 1.5e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 KOS22301.1 - 0.019 14.8 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin Glutaredoxin PF00462.24 KOS22301.1 - 0.029 14.6 0.1 0.038 14.2 0.1 1.5 1 1 0 1 1 1 0 Glutaredoxin Thioredoxin_2 PF13098.6 KOS22301.1 - 0.041 14.3 0.0 0.05 14.1 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain ABC_tran PF00005.27 KOS22302.1 - 1.2e-18 67.9 0.0 2.4e-18 67.0 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 KOS22302.1 - 1.2e-10 41.5 5.0 1.5e-10 41.2 5.0 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_15 PF13175.6 KOS22302.1 - 0.00035 20.4 0.0 0.00051 19.9 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 KOS22302.1 - 0.0018 18.2 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_21 PF13304.6 KOS22302.1 - 0.0031 17.4 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 KOS22302.1 - 0.008 15.5 0.0 0.014 14.7 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 KOS22302.1 - 0.0083 15.9 0.1 0.03 14.1 0.1 1.9 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 KOS22302.1 - 0.032 14.5 0.4 1.1 9.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 KOS22302.1 - 0.06 13.8 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 KOS22302.1 - 0.076 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase NiFe_hyd_3_EhaA PF17367.2 KOS22302.1 - 0.087 13.0 0.1 0.23 11.6 0.1 1.7 1 0 0 1 1 1 0 NiFe-hydrogenase-type-3 Eha complex subunit A MMR_HSR1 PF01926.23 KOS22302.1 - 0.13 12.4 0.0 0.28 11.3 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 KOS22302.1 - 0.13 11.4 0.0 0.29 10.3 0.0 1.7 2 0 0 2 2 2 0 G-protein alpha subunit SGTA_dimer PF16546.5 KOS22303.1 - 4.2e-24 84.1 2.2 8.5e-24 83.1 2.2 1.5 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 KOS22303.1 - 1.1e-20 72.5 1.7 2.8e-08 33.2 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22303.1 - 1.3e-17 62.4 2.7 3.2e-06 26.8 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS22303.1 - 1.9e-11 43.4 1.3 5.2e-06 26.1 0.2 3.4 2 1 1 3 3 3 3 TPR repeat TPR_14 PF13428.6 KOS22303.1 - 4.9e-11 42.5 2.5 0.0018 19.0 0.1 3.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOS22303.1 - 6.5e-10 39.5 6.0 3e-06 27.8 1.9 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22303.1 - 2e-09 36.9 3.1 0.0016 18.5 0.0 3.9 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 KOS22303.1 - 9.9e-08 31.9 2.5 0.0019 18.4 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS22303.1 - 1.6e-07 31.7 1.0 0.0046 17.4 0.4 3.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOS22303.1 - 2.9e-07 30.0 0.1 0.013 15.5 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22303.1 - 2.1e-06 27.9 5.3 0.00071 19.8 2.3 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 KOS22303.1 - 0.00023 20.9 3.7 2.2 8.3 0.3 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOS22303.1 - 0.00028 21.3 0.5 1.4 9.7 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS22303.1 - 0.00049 20.2 2.2 0.026 14.7 0.1 3.4 3 1 1 4 4 3 1 Tetratricopeptide repeat BTAD PF03704.17 KOS22303.1 - 0.0016 18.9 1.3 0.24 11.8 0.2 2.4 1 1 1 2 2 2 1 Bacterial transcriptional activator domain STI1 PF17830.1 KOS22303.1 - 0.0036 17.2 5.4 0.0036 17.2 5.4 2.3 2 0 0 2 2 2 1 STI1 domain MIT PF04212.18 KOS22303.1 - 0.0095 16.0 0.8 0.71 10.0 0.1 2.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain GHBP PF12772.7 KOS22303.1 - 0.071 12.6 4.0 0.1 12.1 4.0 1.1 1 0 0 1 1 1 0 Growth hormone receptor binding RINGv PF12906.7 KOS22304.1 - 0.00058 19.9 9.1 0.00098 19.2 9.1 1.4 1 0 0 1 1 1 1 RING-variant domain Pex14_N PF04695.13 KOS22304.1 - 0.0054 17.4 0.3 0.01 16.5 0.3 1.4 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Androgen_recep PF02166.16 KOS22304.1 - 0.014 14.3 5.1 0.023 13.5 5.1 1.3 1 0 0 1 1 1 0 Androgen receptor zf-RING_2 PF13639.6 KOS22304.1 - 0.022 15.1 10.4 0.033 14.5 10.4 1.3 1 0 0 1 1 1 0 Ring finger domain SUIM_assoc PF16619.5 KOS22304.1 - 0.032 14.3 8.5 0.33 11.1 8.5 2.3 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2722 PF10846.8 KOS22304.1 - 0.11 11.4 7.2 0.19 10.6 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FANCL_C PF11793.8 KOS22304.1 - 0.25 11.5 5.8 0.5 10.6 5.8 1.5 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 KOS22304.1 - 0.8 9.5 9.2 1.3 8.9 9.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Presenilin PF01080.17 KOS22304.1 - 1.1 7.9 4.6 1.7 7.3 4.6 1.2 1 0 0 1 1 1 0 Presenilin zf-C3HC4 PF00097.25 KOS22304.1 - 5.3 7.0 8.3 8.5 6.4 8.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) GalKase_gal_bdg PF10509.9 KOS22305.1 - 3.1e-21 74.6 0.1 5.8e-21 73.8 0.1 1.5 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_C PF08544.13 KOS22305.1 - 4e-15 55.9 0.0 9.2e-15 54.8 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 KOS22305.1 - 1.6e-08 34.6 1.9 1.6e-08 34.6 1.9 2.5 3 0 0 3 3 3 1 GHMP kinases N terminal domain Sigma70_r4_2 PF08281.12 KOS22305.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-70, region 4 TPP_enzyme_N PF02776.18 KOS22306.1 - 1.3e-55 187.6 0.1 7.5e-54 181.9 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 KOS22306.1 - 7.6e-49 165.4 0.8 2.2e-47 160.7 0.1 2.8 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 KOS22306.1 - 5e-40 136.4 0.8 2.1e-39 134.4 0.6 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 KOS22306.1 - 0.11 12.2 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg zf-C2H2 PF00096.26 KOS22307.1 - 0.23 12.0 7.6 4.3 8.0 1.1 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Mito_carr PF00153.27 KOS22308.1 - 1e-23 83.1 3.7 1.6e-13 50.3 0.2 3.5 3 1 0 3 3 3 2 Mitochondrial carrier protein Thr_synth_N PF14821.6 KOS22309.1 - 6.4e-28 96.8 0.0 2.3e-27 95.0 0.0 2.0 2 0 0 2 2 2 1 Threonine synthase N terminus PALP PF00291.25 KOS22309.1 - 1.7e-20 73.6 0.0 1.7e-19 70.3 0.0 2.0 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DFRP_C PF16543.5 KOS22310.1 - 6.9e-26 90.6 7.9 6.9e-26 90.6 7.9 3.6 3 1 0 3 3 3 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 KOS22310.1 - 2.8e-06 27.1 0.8 2.8e-06 27.1 0.8 2.5 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 KOS22310.1 - 7.9e-06 26.5 4.1 7.9e-06 26.5 4.1 3.7 2 2 2 4 4 4 2 Torus domain zf-CCCH_4 PF18044.1 KOS22310.1 - 0.00026 20.7 10.7 0.0043 16.8 1.8 3.3 3 0 0 3 3 3 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOS22310.1 - 0.00033 20.6 5.5 0.00033 20.6 5.5 3.2 3 0 0 3 3 3 1 Zinc finger domain zf-CCCH_3 PF15663.5 KOS22310.1 - 0.0056 16.9 0.5 0.23 11.7 0.2 2.6 2 0 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOS22310.1 - 0.015 15.8 13.8 0.15 12.6 5.5 2.9 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Mito_carr PF00153.27 KOS22311.1 - 7.4e-11 41.8 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial carrier protein Sbi-IV PF11621.8 KOS22312.1 - 0.081 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 C3 binding domain 4 of IgG-bind protein SBI Ras PF00071.22 KOS22313.1 - 4.9e-65 218.0 0.7 5.9e-65 217.8 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS22313.1 - 6.6e-36 123.2 0.2 1.2e-35 122.3 0.2 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS22313.1 - 2.2e-16 59.8 0.1 2.7e-16 59.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 KOS22313.1 - 1.7e-05 24.9 0.0 6.4e-05 23.0 0.0 1.9 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS22313.1 - 2.7e-05 24.1 0.8 0.13 12.2 0.0 2.5 1 1 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 KOS22313.1 - 5.8e-05 22.7 0.5 0.00015 21.4 0.2 1.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 KOS22313.1 - 0.00015 21.2 0.1 0.00019 20.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOS22313.1 - 0.00034 20.1 0.1 0.00049 19.6 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 KOS22313.1 - 0.0029 18.0 0.1 0.63 10.5 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) FeoB_N PF02421.18 KOS22313.1 - 0.0051 16.4 0.0 0.029 13.9 0.0 1.9 1 1 0 1 1 1 1 Ferrous iron transport protein B AAA_16 PF13191.6 KOS22313.1 - 0.011 16.2 0.0 0.017 15.5 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 KOS22313.1 - 0.034 14.4 0.0 0.085 13.1 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 KOS22313.1 - 0.041 13.4 0.0 0.092 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 KOS22313.1 - 0.052 13.3 0.0 0.14 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 KOS22313.1 - 0.073 13.1 0.0 0.11 12.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) TniB PF05621.11 KOS22313.1 - 0.077 12.4 0.0 0.21 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 KOS22313.1 - 0.098 13.2 0.0 0.16 12.5 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_25 PF13481.6 KOS22313.1 - 0.1 12.2 0.0 1.6 8.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mcl1_mid PF12341.8 KOS22314.1 - 3.6e-100 335.2 0.0 1.5e-98 329.9 0.0 2.2 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region WD40 PF00400.32 KOS22314.1 - 3.9e-17 62.3 3.2 0.00014 22.6 0.0 7.1 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22314.1 - 6.1e-14 52.1 0.0 0.00075 19.7 0.0 6.8 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 KOS22314.1 - 1.3e-05 24.4 0.0 0.00039 19.6 0.0 2.1 1 1 1 2 2 2 1 Coatomer WD associated region eIF2A PF08662.11 KOS22314.1 - 0.0036 17.2 0.0 0.033 14.1 0.1 2.2 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Pox_Ag35 PF03286.14 KOS22314.1 - 0.023 14.5 5.3 0.044 13.6 5.3 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Ge1_WD40 PF16529.5 KOS22314.1 - 0.066 12.2 0.1 4.8 6.0 0.0 3.2 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein FAM176 PF14851.6 KOS22314.1 - 3.9 7.1 6.5 8.5 6.0 6.5 1.5 1 0 0 1 1 1 0 FAM176 family DNA_pol_alpha_N PF12254.8 KOS22314.1 - 9.2 6.4 12.6 2.5 8.2 6.0 3.0 3 0 0 3 3 3 0 DNA polymerase alpha subunit p180 N terminal WD40 PF00400.32 KOS22315.1 - 5.5e-15 55.5 9.5 0.014 16.2 0.1 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat Sigma70_r1_2 PF00140.20 KOS22315.1 - 0.034 14.2 2.3 0.073 13.1 2.3 1.5 1 0 0 1 1 1 0 Sigma-70 factor, region 1.2 PQQ_3 PF13570.6 KOS22315.1 - 0.06 13.9 0.1 0.06 13.9 0.1 3.9 5 0 0 5 5 5 0 PQQ-like domain CS PF04969.16 KOS22316.1 - 2e-05 25.5 0.1 3.3e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 CS domain DUF4979 PF16351.5 KOS22316.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4979) RRM_1 PF00076.22 KOS22317.1 - 9.2e-15 54.2 0.0 1.6e-14 53.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 KOS22317.1 - 8.9e-05 23.0 3.9 8.9e-05 23.0 3.9 2.6 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_occluded PF16842.5 KOS22317.1 - 0.0025 17.6 0.0 0.0058 16.5 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif DUF5102 PF17104.5 KOS22317.1 - 0.063 13.3 0.1 0.2 11.7 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) MMM1 PF10296.9 KOS22318.1 - 7.2e-07 28.6 6.5 3.5e-06 26.3 0.0 2.8 2 1 1 3 3 3 2 Maintenance of mitochondrial morphology protein 1 PGA2 PF07543.12 KOS22318.1 - 0.14 12.2 1.7 0.33 10.9 1.7 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 PH_11 PF15413.6 KOS22318.1 - 0.25 11.8 1.3 1.6 9.2 0.0 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain Mcp5_PH PF12814.7 KOS22320.1 - 3.1e-44 150.0 0.0 5.4e-44 149.2 0.0 1.4 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH PF00169.29 KOS22320.1 - 0.00011 22.7 0.0 0.00027 21.4 0.0 1.7 1 0 0 1 1 1 1 PH domain AAA_9 PF12781.7 KOS22320.1 - 0.0013 17.9 0.3 0.0013 17.9 0.3 2.4 1 1 1 2 2 2 1 ATP-binding dynein motor region MCC-bdg_PDZ PF10506.9 KOS22320.1 - 1.3 9.0 9.5 6.9 6.8 1.2 2.7 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Gp-FAR-1 PF05823.12 KOS22320.1 - 4.8 7.5 9.8 17 5.7 0.1 2.7 2 0 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) AdoMet_Synthase PF01941.19 KOS22321.1 - 0.24 10.1 0.0 0.32 9.7 0.0 1.1 1 0 0 1 1 1 0 S-adenosylmethionine synthetase (AdoMet synthetase) Ribosomal_L21e PF01157.18 KOS22322.1 - 1.4e-47 159.7 6.2 3.7e-47 158.3 5.3 1.8 2 0 0 2 2 2 1 Ribosomal protein L21e DUF5486 PF17588.2 KOS22322.1 - 0.0035 17.2 2.8 0.12 12.3 0.2 2.4 2 0 0 2 2 2 2 Family of unknown function (DUF5486) NaeI PF09126.10 KOS22322.1 - 0.089 12.0 0.4 0.12 11.6 0.4 1.2 1 0 0 1 1 1 0 Restriction endonuclease NaeI S4 PF01479.25 KOS22323.1 - 3.9e-12 45.7 0.6 3.9e-12 45.7 0.6 2.6 3 0 0 3 3 3 1 S4 domain Ribosomal_S4 PF00163.19 KOS22323.1 - 9.4e-06 26.5 0.0 1.8e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Slu7 PF11708.8 KOS22324.1 - 8.9e-69 232.2 16.6 8.9e-69 232.2 16.6 3.3 3 1 0 3 3 3 1 Pre-mRNA splicing Prp18-interacting factor zf-CCHC PF00098.23 KOS22324.1 - 0.078 13.1 2.8 0.16 12.1 2.8 1.5 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 KOS22324.1 - 0.08 12.7 0.6 0.15 11.8 0.6 1.4 1 0 0 1 1 1 0 Zinc knuckle Alpha-amylase PF00128.24 KOS22324.1 - 0.1 12.2 3.9 0.11 12.1 0.0 2.6 3 0 0 3 3 3 0 Alpha amylase, catalytic domain DNA_pol_B PF00136.21 KOS22325.1 - 1.9e-102 343.3 0.0 2.4e-102 343.0 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-C4pol PF14260.6 KOS22325.1 - 4.9e-17 62.1 5.3 4.9e-17 62.1 5.3 1.8 2 0 0 2 2 2 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_exo1 PF03104.19 KOS22325.1 - 7.4e-11 41.8 0.0 1.2e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain Ribosomal_S14 PF00253.21 KOS22325.1 - 0.0047 16.7 0.6 0.012 15.4 0.6 1.7 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e DNA_pol_B_2 PF03175.13 KOS22325.1 - 0.15 10.9 0.2 0.23 10.3 0.2 1.2 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral FYVE PF01363.21 KOS22325.1 - 0.5 10.5 2.7 1 9.6 2.7 1.5 1 0 0 1 1 1 0 FYVE zinc finger Exo_endo_phos PF03372.23 KOS22326.1 - 2.4e-14 53.4 0.1 3.9e-14 52.7 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KOS22326.1 - 0.00011 22.0 0.0 0.077 12.8 0.0 2.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase I_LWEQ PF01608.17 KOS22327.1 - 5.7e-55 185.8 8.9 5.7e-55 185.8 8.9 6.4 3 2 3 7 7 7 3 I/LWEQ domain ANTH PF07651.16 KOS22327.1 - 9.3e-52 175.7 2.0 9.3e-52 175.7 2.0 3.5 1 1 2 3 3 3 1 ANTH domain Het-C PF07217.11 KOS22327.1 - 0.0022 16.6 2.1 0.0022 16.6 2.1 2.9 1 1 2 3 3 3 1 Heterokaryon incompatibility protein Het-C ISN1 PF06437.11 KOS22328.1 - 1.3e-196 653.4 0.0 1.7e-196 653.0 0.0 1.1 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase PV-1 PF06637.11 KOS22328.1 - 0.19 10.5 0.0 0.29 9.9 0.0 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) IBN_N PF03810.19 KOS22329.1 - 4.5e-12 45.7 4.2 3.9e-11 42.7 0.0 3.5 3 0 0 3 3 3 1 Importin-beta N-terminal domain Cse1 PF08506.10 KOS22329.1 - 2.9e-08 32.9 0.0 8.6e-08 31.4 0.0 1.9 1 0 0 1 1 1 1 Cse1 Xpo1 PF08389.12 KOS22329.1 - 6e-05 23.1 3.7 0.00023 21.2 0.5 3.5 4 0 0 4 4 4 1 Exportin 1-like protein GRIP PF01465.20 KOS22329.1 - 0.057 13.3 0.2 0.44 10.5 0.1 2.7 2 1 0 2 2 2 0 GRIP domain MOR2-PAG1_C PF14225.6 KOS22329.1 - 0.2 11.5 1.8 0.4 10.5 0.2 2.4 2 0 0 2 2 2 0 Cell morphogenesis C-terminal Vac14_Fab1_bd PF12755.7 KOS22329.1 - 0.33 11.6 1.3 4.2 8.0 0.1 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region Cnl2_NKP2 PF09447.10 KOS22329.1 - 0.49 10.6 2.8 0.39 10.9 0.5 2.1 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Cnd1 PF12717.7 KOS22329.1 - 0.62 10.1 3.7 1 9.4 0.1 3.1 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 CAF1A PF12253.8 KOS22329.1 - 2 8.6 9.4 5.6 7.2 9.4 1.7 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A IMS PF00817.20 KOS22331.1 - 1.2e-40 138.9 0.0 1.8e-40 138.3 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KOS22331.1 - 2.1e-11 44.6 0.0 4.4e-11 43.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 KOS22331.1 - 7.8e-07 28.6 0.1 1.5e-06 27.7 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger IMS_HHH PF11798.8 KOS22331.1 - 0.0014 18.9 1.0 0.0025 18.0 0.0 2.0 2 0 0 2 2 2 1 IMS family HHH motif Atg14 PF10186.9 KOS22332.1 - 0.1 11.7 1.7 0.16 11.1 1.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2312 PF10073.9 KOS22332.1 - 0.29 10.8 2.6 5.5 6.7 0.7 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) Ank_2 PF12796.7 KOS22333.1 - 1.5e-08 35.1 0.1 5.3e-06 26.9 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) F-box-like PF12937.7 KOS22333.1 - 4.9e-06 26.3 0.1 1.1e-05 25.3 0.1 1.5 1 0 0 1 1 1 1 F-box-like Ank_5 PF13857.6 KOS22333.1 - 4.6e-05 23.6 1.3 0.16 12.3 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS22333.1 - 6e-05 23.1 0.3 0.66 10.7 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 KOS22333.1 - 7.7e-05 23.2 1.2 0.16 12.6 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Pkinase PF00069.25 KOS22334.1 - 1.7e-50 171.9 0.0 2.3e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22334.1 - 6.2e-26 91.2 0.6 8.6e-25 87.5 0.6 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS22334.1 - 0.0022 16.9 0.0 0.0033 16.2 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS22334.1 - 0.013 14.8 0.1 0.028 13.7 0.1 1.4 1 0 0 1 1 1 0 Kinase-like zf-C3HC4_3 PF13920.6 KOS22336.1 - 5.1e-08 32.6 5.1 8.6e-08 31.9 5.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-CCCH PF00642.24 KOS22336.1 - 5.5e-08 32.5 1.9 1.1e-07 31.6 1.9 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4 PF00097.25 KOS22336.1 - 3.7e-07 29.9 9.8 6.1e-07 29.2 9.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 KOS22336.1 - 1e-06 28.5 8.7 1.7e-06 27.8 8.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS22336.1 - 1.1e-06 28.6 6.9 2.1e-06 27.7 6.9 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 KOS22336.1 - 1.1e-05 25.3 8.1 1.8e-05 24.6 8.1 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 KOS22336.1 - 6.5e-05 23.2 7.0 0.00012 22.3 7.0 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_10 PF16685.5 KOS22336.1 - 9.4e-05 22.5 3.6 0.00019 21.5 3.6 1.5 1 0 0 1 1 1 1 zinc RING finger of MSL2 zf_CCCH_4 PF18345.1 KOS22336.1 - 0.00024 21.0 4.9 0.00044 20.2 4.9 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 KOS22336.1 - 0.00032 20.4 2.4 0.00054 19.7 2.4 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger zf-C3HC4_4 PF15227.6 KOS22336.1 - 0.0012 18.9 8.8 0.0027 17.8 8.8 1.6 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 KOS22336.1 - 0.0016 18.3 5.6 0.0029 17.4 5.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 KOS22336.1 - 0.092 13.1 3.6 0.18 12.1 3.6 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain Autophagy_N PF03986.13 KOS22337.1 - 4.1e-46 156.3 0.2 7.2e-46 155.5 0.0 1.5 2 0 0 2 2 2 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 KOS22337.1 - 4.7e-16 58.0 0.6 9.8e-16 57.0 0.6 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 KOS22337.1 - 1.7e-15 57.3 0.1 3.3e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain ADP_ribosyl_GH PF03747.14 KOS22338.1 - 5.5e-58 197.0 0.4 6.5e-58 196.8 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Abhydrolase_6 PF12697.7 KOS22339.1 - 1.3e-05 25.9 5.2 1.3e-05 25.9 5.2 1.6 1 1 1 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 KOS22339.1 - 0.00072 18.9 0.2 0.029 13.7 0.1 2.2 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 KOS22339.1 - 0.0059 16.1 0.1 0.04 13.4 0.0 2.1 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 KOS22339.1 - 0.0069 16.3 0.0 0.024 14.5 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold BAAT_C PF08840.11 KOS22339.1 - 0.045 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 KOS22339.1 - 0.096 12.2 0.0 5.8 6.4 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Peptidase_S15 PF02129.18 KOS22339.1 - 0.1 12.1 0.1 0.25 10.9 0.0 1.5 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Ras PF00071.22 KOS22340.1 - 1.1e-50 171.4 0.0 1.3e-50 171.2 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS22340.1 - 5e-22 78.4 0.0 6.7e-22 78.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS22340.1 - 2.7e-06 26.9 0.0 4.1e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 KOS22340.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region SRPRB PF09439.10 KOS22340.1 - 0.016 14.6 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 KOS22340.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 KOS22340.1 - 0.11 12.3 0.0 2.4 7.9 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 KOS22340.1 - 0.21 11.4 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF3446 PF11928.8 KOS22341.1 - 2.6 8.4 9.5 5.2 7.5 9.5 1.5 1 1 0 1 1 1 0 Early growth response N-terminal domain Pkinase PF00069.25 KOS22343.1 - 6.5e-54 183.1 0.0 8.5e-54 182.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22343.1 - 1e-32 113.4 0.0 1.5e-32 112.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS22343.1 - 0.00016 21.1 0.0 0.00038 19.9 0.0 1.5 2 0 0 2 2 2 1 Kinase-like FTA2 PF13095.6 KOS22343.1 - 0.0004 20.1 0.5 0.3 10.7 0.0 2.6 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 KOS22343.1 - 0.0048 16.3 0.0 0.0077 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 KOS22343.1 - 0.0096 14.9 0.0 0.014 14.4 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 KOS22343.1 - 0.031 13.2 0.0 0.055 12.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 KOS22343.1 - 0.032 14.2 0.0 0.076 12.9 0.0 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family zf-CCHC_5 PF14787.6 KOS22343.1 - 0.062 13.0 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DUF805 PF05656.14 KOS22344.1 - 0.037 14.4 0.9 0.05 14.0 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF805) RRM_1 PF00076.22 KOS22345.1 - 0.023 14.5 0.0 0.045 13.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Acetyltransf_1 PF00583.25 KOS22346.1 - 6.6e-11 42.5 0.1 1.4e-10 41.4 0.1 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 KOS22346.1 - 4.1e-08 33.5 0.0 6.5e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS22346.1 - 4.1e-08 33.2 0.0 6.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS22346.1 - 4.1e-06 26.7 0.0 6.9e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein DUF3446 PF11928.8 KOS22346.1 - 0.026 14.8 10.9 0.14 12.5 1.0 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain Acetyltransf_9 PF13527.7 KOS22346.1 - 0.034 14.2 0.0 0.061 13.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CDV3 PF15359.6 KOS22347.1 - 0.0052 17.3 0.9 0.0067 16.9 0.9 1.2 1 0 0 1 1 1 1 Carnitine deficiency-associated protein 3 Alph_Pro_TM PF09608.10 KOS22347.1 - 0.013 15.3 0.4 0.017 14.9 0.4 1.1 1 0 0 1 1 1 0 Putative transmembrane protein (Alph_Pro_TM) DUF4407 PF14362.6 KOS22347.1 - 0.023 14.1 0.4 0.023 14.1 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FixO PF02433.15 KOS22347.1 - 0.023 14.1 1.4 0.029 13.8 1.4 1.1 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO UPF0560 PF10577.9 KOS22347.1 - 0.029 12.9 8.0 0.033 12.7 8.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CNDH2_M PF16869.5 KOS22347.1 - 0.03 15.0 3.6 0.038 14.7 3.6 1.1 1 0 0 1 1 1 0 PF16858 Spt20 PF12090.8 KOS22347.1 - 0.037 13.6 13.8 0.043 13.4 13.8 1.1 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KOS22347.1 - 0.067 13.2 11.9 0.066 13.2 11.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med26_M PF15694.5 KOS22347.1 - 0.25 11.4 12.4 0.29 11.1 12.4 1.0 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain GTA_holin_3TM PF11351.8 KOS22347.1 - 0.9 10.1 5.1 1.2 9.7 5.1 1.1 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release FlxA PF14282.6 KOS22347.1 - 7.4 6.6 31.4 12 5.9 31.4 1.3 1 0 0 1 1 1 0 FlxA-like protein Lyase_1 PF00206.20 KOS22350.1 - 3.9e-88 295.9 0.0 5.6e-88 295.3 0.0 1.2 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 KOS22350.1 - 8.2e-26 90.6 0.0 2.3e-25 89.1 0.0 1.8 1 0 0 1 1 1 1 Argininosuccinate lyase C-terminal SHOCT PF09851.9 KOS22350.1 - 0.07 12.9 0.0 0.26 11.1 0.0 2.0 1 0 0 1 1 1 0 Short C-terminal domain TPD52 PF04201.15 KOS22350.1 - 0.12 12.0 0.0 0.36 10.4 0.0 1.7 2 0 0 2 2 2 0 Tumour protein D52 family GARS_A PF01071.19 KOS22351.1 - 5.4e-81 271.0 0.0 8.8e-81 270.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain AIRS_C PF02769.22 KOS22351.1 - 1.1e-35 123.0 0.4 2.7e-35 121.8 0.4 1.7 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_N PF02844.15 KOS22351.1 - 4.8e-34 117.0 0.0 1.3e-33 115.6 0.0 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 KOS22351.1 - 1.7e-25 89.1 2.5 5.2e-25 87.5 0.3 2.8 3 1 0 3 3 3 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 KOS22351.1 - 1e-12 48.5 5.2 2.1e-12 47.5 3.5 2.3 1 1 1 2 2 2 1 AIR synthase related protein, N-terminal domain CPSase_L_D2 PF02786.17 KOS22351.1 - 9.9e-05 21.9 0.1 0.00018 21.0 0.1 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp PF02222.22 KOS22351.1 - 0.0022 17.6 0.0 0.0045 16.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 KOS22351.1 - 0.04 13.5 0.2 0.16 11.6 0.0 1.9 2 0 0 2 2 2 0 RimK-like ATP-grasp domain ATP-grasp_2 PF08442.10 KOS22351.1 - 0.049 13.2 0.1 0.085 12.4 0.1 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_3 PF02655.14 KOS22351.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_4 PF13535.6 KOS22351.1 - 0.15 11.6 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain MFS_1 PF07690.16 KOS22352.1 - 9.3e-31 107.0 54.0 4.7e-25 88.3 34.0 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS22352.1 - 3e-11 42.9 29.5 8.3e-11 41.4 29.5 1.9 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOS22352.1 - 0.74 8.6 17.7 0.02 13.8 9.2 2.3 2 1 1 3 3 3 0 MFS_1 like family DUF1992 PF09350.10 KOS22353.1 - 2.4e-20 72.5 0.9 5.3e-20 71.3 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1992) PTR2 PF00854.21 KOS22354.1 - 4.7e-86 289.1 8.0 1.1e-85 287.9 8.0 1.5 1 1 0 1 1 1 1 POT family Fe-S_biosyn PF01521.20 KOS22355.1 - 8.2e-20 71.1 0.0 1.1e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.7 KOS22355.1 - 0.22 11.7 0.0 0.39 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) NAM-associated PF14303.6 KOS22355.1 - 0.72 10.6 3.8 1.2 9.9 3.8 1.3 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DNA_binding_1 PF01035.20 KOS22356.1 - 1.6e-27 95.5 0.0 2.1e-27 95.0 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Abhydrolase_4 PF08386.10 KOS22357.1 - 4.5e-20 71.7 0.0 1e-19 70.5 0.0 1.6 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_1 PF00561.20 KOS22357.1 - 5.8e-17 62.2 0.0 2.2e-16 60.3 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ras PF00071.22 KOS22358.1 - 8.6e-43 145.7 0.0 1.1e-42 145.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS22358.1 - 1.5e-11 44.5 0.0 2.4e-11 43.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS22358.1 - 1.4e-05 24.7 0.0 2e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 KOS22358.1 - 0.00067 19.2 0.0 0.00084 18.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Scytalone_dh PF02982.14 KOS22358.1 - 0.057 13.2 0.0 0.087 12.6 0.0 1.2 1 0 0 1 1 1 0 Scytalone dehydratase Tcp11 PF05794.13 KOS22359.1 - 1.8e-89 300.9 0.1 1.8e-89 300.9 0.1 2.2 2 0 0 2 2 2 1 T-complex protein 11 UPF0242 PF06785.11 KOS22359.1 - 6.6 6.8 6.3 12 5.9 6.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Y_phosphatase PF00102.27 KOS22360.1 - 2e-58 197.8 0.0 6.8e-51 173.1 0.0 3.1 2 1 0 2 2 2 2 Protein-tyrosine phosphatase Rhodanese PF00581.20 KOS22360.1 - 4.8e-10 39.9 0.0 3e-09 37.3 0.0 2.4 4 0 0 4 4 4 1 Rhodanese-like domain Y_phosphatase3 PF13350.6 KOS22360.1 - 0.055 13.4 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DSPc PF00782.20 KOS22360.1 - 0.064 13.1 0.3 0.15 11.9 0.3 1.6 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF1989 PF09347.10 KOS22361.1 - 3.5e-61 205.7 0.0 4.3e-61 205.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) AAA PF00004.29 KOS22362.1 - 1.5e-43 148.4 0.0 2.4e-43 147.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS22362.1 - 1.1e-14 53.9 0.0 4.3e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 KOS22362.1 - 3.6e-07 30.2 0.0 9.7e-07 28.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 KOS22362.1 - 5.7e-07 29.8 0.0 1.1e-06 28.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 KOS22362.1 - 7.5e-07 29.0 1.9 1.9e-06 27.7 1.9 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_16 PF13191.6 KOS22362.1 - 5.6e-06 26.8 0.0 0.00011 22.6 0.1 2.6 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 KOS22362.1 - 6.2e-05 23.3 0.3 0.016 15.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 KOS22362.1 - 0.0001 22.1 0.0 0.0002 21.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOS22362.1 - 0.00046 20.7 0.0 0.015 15.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain Prot_ATP_OB_N PF17758.1 KOS22362.1 - 0.00072 19.2 0.1 0.0025 17.4 0.1 2.0 1 1 0 1 1 1 1 Proteasomal ATPase OB N-terminal domain IstB_IS21 PF01695.17 KOS22362.1 - 0.0011 18.7 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 KOS22362.1 - 0.0014 18.8 0.0 0.0028 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 KOS22362.1 - 0.0017 17.6 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 KOS22362.1 - 0.0065 15.9 0.1 0.016 14.6 0.1 1.6 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase PF06745.13 KOS22362.1 - 0.0067 15.8 0.0 0.014 14.7 0.0 1.5 1 0 0 1 1 1 1 KaiC AAA_3 PF07726.11 KOS22362.1 - 0.0091 15.9 0.0 0.029 14.3 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOS22362.1 - 0.011 15.3 0.0 0.029 14.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 KOS22362.1 - 0.012 14.7 0.0 0.022 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 KOS22362.1 - 0.012 15.8 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 KOS22362.1 - 0.013 15.5 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 KOS22362.1 - 0.022 14.2 0.0 0.096 12.1 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein AAA_24 PF13479.6 KOS22362.1 - 0.026 14.3 0.0 0.077 12.7 0.0 1.8 3 0 0 3 3 1 0 AAA domain Sigma54_activat PF00158.26 KOS22362.1 - 0.027 14.2 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_14 PF13173.6 KOS22362.1 - 0.032 14.3 0.0 0.056 13.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOS22362.1 - 0.034 14.5 0.0 0.062 13.7 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 KOS22362.1 - 0.046 13.2 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region HR1 PF02185.16 KOS22362.1 - 0.072 13.2 0.8 0.18 11.9 0.8 1.7 1 0 0 1 1 1 0 Hr1 repeat Parvo_NS1 PF01057.17 KOS22362.1 - 0.082 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 Zeta_toxin PF06414.12 KOS22362.1 - 0.12 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 KOS22362.1 - 0.12 12.2 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS22362.1 - 0.13 12.2 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Na_Ca_ex PF01699.24 KOS22363.1 - 4.7e-24 85.1 30.0 3.7e-17 62.7 13.4 3.6 5 0 0 5 5 5 2 Sodium/calcium exchanger protein YccF PF03733.13 KOS22363.1 - 3.6e-15 56.4 11.6 3.6e-15 56.4 11.6 4.2 2 0 0 2 2 2 1 Inner membrane component domain RNA_pol_3_Rpc31 PF11705.8 KOS22363.1 - 0.089 13.0 10.6 0.15 12.3 10.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop14 PF04147.12 KOS22363.1 - 0.21 9.8 15.4 0.3 9.3 15.4 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 KOS22363.1 - 0.31 10.7 17.8 0.53 10.0 17.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein GCIP PF13324.6 KOS22363.1 - 1.5 8.4 5.6 2.8 7.5 5.6 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Pax7 PF12360.8 KOS22363.1 - 2.6 8.3 5.5 10 6.4 0.4 2.9 3 0 0 3 3 3 0 Paired box protein 7 TPPK_C PF12555.8 KOS22363.1 - 2.6 8.2 8.0 2.4 8.3 0.6 3.0 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Sporozoite_P67 PF05642.11 KOS22363.1 - 6.3 4.7 7.6 9.5 4.2 7.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.12 KOS22363.1 - 7.7 4.4 6.4 11 3.8 6.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Clathrin PF00637.20 KOS22364.1 - 7.2e-23 81.0 0.7 2.5e-20 72.8 0.1 2.6 2 0 0 2 2 2 1 Region in Clathrin and VPS VPS11_C PF12451.8 KOS22364.1 - 1.6e-17 63.4 0.3 3.6e-17 62.3 0.3 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 KOS22364.1 - 1.7e-07 31.2 4.7 3.9e-07 30.0 4.7 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 KOS22364.1 - 9.8e-05 22.1 4.5 0.00026 20.8 4.5 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS22364.1 - 0.00081 19.3 4.5 0.0018 18.2 4.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain TPR_14 PF13428.6 KOS22364.1 - 0.0023 18.6 1.7 4 8.5 0.0 4.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOS22364.1 - 0.004 16.8 0.1 0.0099 15.5 0.1 1.7 1 0 0 1 1 1 1 TPR repeat zf-RING_2 PF13639.6 KOS22364.1 - 0.018 15.4 4.5 0.047 14.0 4.5 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 KOS22364.1 - 0.018 14.9 4.2 0.051 13.5 4.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS22364.1 - 0.05 13.9 2.9 0.12 12.7 2.9 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Atg14 PF10186.9 KOS22364.1 - 0.11 11.5 0.3 0.25 10.4 0.3 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 zf-ANAPC11 PF12861.7 KOS22364.1 - 0.12 12.4 0.3 0.29 11.2 0.3 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger TPR_21 PF09976.9 KOS22364.1 - 0.17 11.6 0.3 0.66 9.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain TPR_12 PF13424.6 KOS22364.1 - 0.48 10.7 4.9 0.7 10.2 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat zf-RING_UBOX PF13445.6 KOS22364.1 - 0.52 10.4 6.1 1.4 9.0 6.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger TPR_16 PF13432.6 KOS22364.1 - 0.92 10.2 4.3 2.9 8.6 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOS22364.1 - 1.8 9.1 5.7 2.9 8.5 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-RING-like PF08746.11 KOS22364.1 - 4.3 7.7 7.0 1.4 9.3 3.6 2.0 2 0 0 2 2 2 0 RING-like domain STIL_N PF15253.6 KOS22365.1 - 10 5.0 12.2 1.9 7.3 0.5 2.1 2 0 0 2 2 2 0 SCL-interrupting locus protein N-terminus UPF0016 PF01169.19 KOS22367.1 - 1.9e-40 137.1 25.5 2.5e-21 75.8 9.8 2.2 2 0 0 2 2 2 2 Uncharacterized protein family UPF0016 TerC PF03741.16 KOS22367.1 - 0.02 14.6 0.0 0.02 14.6 0.0 2.2 2 1 0 2 2 2 0 Integral membrane protein TerC family RNA_pol_N PF01194.17 KOS22368.1 - 0.063 13.6 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 RNA polymerases N / 8 kDa subunit SET PF00856.28 KOS22369.1 - 1.9e-09 38.1 0.0 2.7e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 SET domain WD40 PF00400.32 KOS22370.1 - 1.9e-17 63.3 22.9 9.4e-05 23.1 2.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22370.1 - 7.5e-05 23.0 0.0 0.007 16.6 0.1 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 KOS22370.1 - 0.021 14.8 1.2 0.083 12.9 0.1 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat SDA1 PF05285.12 KOS22370.1 - 0.027 13.9 32.2 0.044 13.2 32.2 1.3 1 0 0 1 1 1 0 SDA1 TRP PF06011.12 KOS22372.1 - 6.2e-159 529.3 29.1 7.5e-159 529.0 29.1 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 KOS22372.1 - 4.4e-41 140.5 0.4 8.3e-41 139.6 0.4 1.5 1 0 0 1 1 1 1 ML-like domain SLATT_6 PF18169.1 KOS22372.1 - 0.036 13.7 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 ATP-sulfurylase PF01747.17 KOS22373.1 - 6.5e-87 290.4 0.1 9.4e-87 289.9 0.1 1.2 1 0 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 KOS22373.1 - 6.5e-57 191.8 0.0 1e-56 191.2 0.0 1.3 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 KOS22373.1 - 8e-52 175.1 0.0 1.3e-51 174.5 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain CPT PF07931.12 KOS22373.1 - 0.072 12.9 0.1 0.82 9.5 0.1 2.2 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_33 PF13671.6 KOS22373.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2058 PF09831.9 KOS22374.1 - 0.2 11.8 2.5 0.51 10.5 2.5 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DUF3439 PF11921.8 KOS22374.1 - 1.8 8.5 15.2 4.6 7.2 15.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 KOS22374.1 - 1.9 6.3 8.4 3.6 5.4 8.4 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4612 PF15389.6 KOS22374.1 - 2.2 9.3 5.7 0.61 11.1 0.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4612) PNP_UDP_1 PF01048.20 KOS22375.1 - 0.0038 16.5 0.3 0.0065 15.8 0.3 1.3 1 1 0 1 1 1 1 Phosphorylase superfamily RRM_1 PF00076.22 KOS22376.1 - 4.6e-06 26.4 0.0 7.8e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HIT PF01230.23 KOS22377.1 - 2.2e-16 60.4 0.0 3e-16 59.9 0.0 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KOS22377.1 - 5.5e-05 23.6 0.0 7.9e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 KOS22377.1 - 0.0091 15.9 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DNA_RNApol_7kD PF03604.13 KOS22378.1 - 2.8e-11 42.9 1.1 3.8e-11 42.5 1.1 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Zn-ribbon_8 PF09723.10 KOS22378.1 - 0.0024 17.9 0.7 0.0052 16.9 0.7 1.5 1 1 0 1 1 1 1 Zinc ribbon domain Lar_restr_allev PF14354.6 KOS22378.1 - 0.004 17.5 0.6 0.37 11.2 0.1 2.1 1 1 1 2 2 2 1 Restriction alleviation protein Lar zf-C2HC5 PF06221.13 KOS22378.1 - 0.0057 16.6 0.0 0.007 16.3 0.0 1.1 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type A2L_zn_ribbon PF08792.10 KOS22378.1 - 0.0075 16.0 0.5 0.012 15.3 0.5 1.2 1 0 0 1 1 1 1 A2L zinc ribbon domain zinc_ribbon_9 PF14369.6 KOS22378.1 - 0.0079 16.4 1.0 0.015 15.5 0.9 1.6 1 1 1 2 2 2 1 zinc-ribbon TF_Zn_Ribbon PF08271.12 KOS22378.1 - 0.017 14.6 0.1 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding GFA PF04828.14 KOS22378.1 - 0.021 15.2 0.6 1.7 9.0 0.0 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme PhnA_Zn_Ribbon PF08274.12 KOS22378.1 - 0.021 14.7 0.3 0.035 14.1 0.3 1.4 1 0 0 1 1 1 0 PhnA Zinc-Ribbon DnaJ_CXXCXGXG PF00684.19 KOS22378.1 - 0.023 15.0 0.4 0.033 14.6 0.4 1.4 1 0 0 1 1 1 0 DnaJ central domain HypA PF01155.19 KOS22378.1 - 0.029 14.4 0.2 0.035 14.1 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ISL3 PF14690.6 KOS22378.1 - 0.047 14.4 0.5 0.11 13.2 0.0 1.8 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_ribbon_SprT PF17283.2 KOS22378.1 - 0.056 13.4 1.7 0.28 11.1 1.6 1.9 1 1 1 2 2 2 0 SprT-like zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 KOS22378.1 - 0.084 12.9 2.4 0.38 10.8 2.4 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain YacG PF03884.14 KOS22378.1 - 0.12 12.2 0.4 0.67 9.7 0.1 2.2 3 0 0 3 3 3 0 DNA gyrase inhibitor YacG zf_Rg PF17915.1 KOS22378.1 - 0.41 10.1 2.4 13 5.3 0.2 2.1 1 1 1 2 2 2 0 Reverse gyrase zinc finger ATP_bind_1 PF03029.17 KOS22379.1 - 3.7e-71 239.7 0.0 6e-71 239.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein MeaB PF03308.16 KOS22379.1 - 3.4e-05 23.0 0.0 0.033 13.2 0.0 2.5 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 KOS22379.1 - 0.00016 21.3 0.0 0.014 14.9 0.0 2.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 KOS22379.1 - 0.00051 20.1 0.0 0.0069 16.5 0.0 2.5 2 1 0 2 2 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOS22379.1 - 0.00073 19.8 0.0 0.0042 17.4 0.0 2.3 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 KOS22379.1 - 0.0011 18.7 0.0 0.0028 17.4 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_16 PF13191.6 KOS22379.1 - 0.0017 18.8 0.0 0.0036 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 KOS22379.1 - 0.0021 17.6 0.0 0.063 12.8 0.0 2.6 3 0 0 3 3 3 1 Ferrous iron transport protein B AAA_33 PF13671.6 KOS22379.1 - 0.0026 17.9 2.1 0.013 15.6 0.0 2.8 3 1 0 3 3 3 1 AAA domain cobW PF02492.19 KOS22379.1 - 0.0037 16.9 0.0 0.032 13.8 0.0 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NB-ARC PF00931.22 KOS22379.1 - 0.0043 16.3 0.3 0.0096 15.1 0.0 1.6 2 0 0 2 2 2 1 NB-ARC domain SRP54 PF00448.22 KOS22379.1 - 0.0049 16.5 0.0 0.053 13.1 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain NACHT PF05729.12 KOS22379.1 - 0.005 16.8 0.0 0.0099 15.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_30 PF13604.6 KOS22379.1 - 0.009 15.7 0.0 0.015 15.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 KOS22379.1 - 0.011 15.9 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase PRK PF00485.18 KOS22379.1 - 0.019 14.7 0.0 0.036 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family LRS4 PF10422.9 KOS22379.1 - 0.025 14.2 1.8 0.04 13.5 1.8 1.3 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 AAA_7 PF12775.7 KOS22379.1 - 0.029 13.9 0.0 0.058 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_18 PF13238.6 KOS22379.1 - 0.032 14.8 4.2 0.13 12.8 0.0 2.6 3 0 0 3 3 2 0 AAA domain G-alpha PF00503.20 KOS22379.1 - 0.032 13.4 0.0 0.76 8.9 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit DUF87 PF01935.17 KOS22379.1 - 0.051 13.7 0.3 0.98 9.5 0.0 2.2 2 0 0 2 2 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 KOS22379.1 - 0.052 13.4 0.0 15 5.4 0.0 3.0 3 0 0 3 3 3 0 RsgA GTPase Arf PF00025.21 KOS22379.1 - 0.054 13.0 0.0 3 7.3 0.0 2.7 3 0 0 3 3 3 0 ADP-ribosylation factor family ATPase_2 PF01637.18 KOS22379.1 - 0.074 12.9 0.1 0.28 11.0 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea LRRFIP PF09738.9 KOS22379.1 - 0.099 12.1 6.0 0.14 11.6 6.0 1.1 1 0 0 1 1 1 0 LRRFIP family Thymidylate_kin PF02223.17 KOS22379.1 - 0.15 11.7 0.6 0.87 9.2 0.0 2.3 3 0 0 3 3 2 0 Thymidylate kinase PduV-EutP PF10662.9 KOS22379.1 - 0.16 11.7 0.0 0.75 9.5 0.0 2.1 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Nop25 PF09805.9 KOS22379.1 - 0.46 10.9 7.9 0.74 10.3 7.9 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) BUD22 PF09073.10 KOS22379.1 - 1.1 8.5 11.7 1.5 8.0 11.7 1.1 1 0 0 1 1 1 0 BUD22 PBP1_TM PF14812.6 KOS22379.1 - 1.4 9.3 14.2 0.2 12.0 7.7 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIA PF03153.13 KOS22379.1 - 3.9 7.4 12.9 5.7 6.8 12.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 KOS22379.1 - 7.8 5.7 14.6 12 5.1 14.6 1.2 1 0 0 1 1 1 0 NOA36 protein ChAPs PF09295.10 KOS22380.1 - 9.1e-152 505.6 0.0 1.1e-151 505.3 0.0 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_14 PF13428.6 KOS22380.1 - 6.8e-06 26.5 1.2 0.17 12.8 0.8 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22380.1 - 8.4e-06 25.5 1.0 0.0064 16.5 1.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS22380.1 - 1.7e-05 24.5 1.2 0.085 12.9 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22380.1 - 7e-05 22.7 0.1 0.023 14.9 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 KOS22380.1 - 0.00063 19.8 0.6 0.22 11.7 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOS22380.1 - 0.00075 19.2 0.5 0.56 10.1 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22380.1 - 0.011 16.0 1.2 3 8.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat WSN PF02206.18 KOS22380.1 - 0.2 11.6 0.0 0.58 10.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function TPR_6 PF13174.6 KOS22380.1 - 0.28 11.9 2.7 32 5.5 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat Nop52 PF05997.12 KOS22381.1 - 8.4e-46 156.5 0.0 1.1e-45 156.1 0.0 1.1 1 0 0 1 1 1 1 Nucleolar protein,Nop52 NOA36 PF06524.12 KOS22381.1 - 2.4 7.4 5.8 3.3 7.0 5.8 1.2 1 0 0 1 1 1 0 NOA36 protein UQ_con PF00179.26 KOS22382.1 - 9e-38 129.1 0.0 1e-37 128.9 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS22382.1 - 0.0024 17.6 0.0 0.0027 17.4 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 KOS22382.1 - 0.11 12.3 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 UEV domain RabGAP-TBC PF00566.18 KOS22383.1 - 3.7e-37 128.1 0.2 4.4e-18 65.7 0.0 4.3 4 0 0 4 4 4 4 Rab-GTPase-TBC domain BSP_II PF05432.11 KOS22384.1 - 9.4 5.8 65.2 12 5.5 65.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TPR_19 PF14559.6 KOS22385.1 - 0.00041 20.8 0.8 0.83 10.2 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 KOS22385.1 - 0.049 14.0 0.2 21 5.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat VIT1 PF01988.19 KOS22385.1 - 0.13 12.1 0.0 0.42 10.4 0.0 1.9 1 0 0 1 1 1 0 VIT family TPR_11 PF13414.6 KOS22385.1 - 1.4 8.7 7.4 1.9 8.2 0.2 3.4 3 0 0 3 3 3 0 TPR repeat TPR_14 PF13428.6 KOS22385.1 - 7.1 7.7 11.1 15 6.8 0.2 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat DEAD PF00270.29 KOS22386.1 - 7.9e-47 159.3 0.0 1.2e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS22386.1 - 6e-29 100.6 0.0 2.1e-28 98.9 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS22386.1 - 1.6e-05 25.0 0.0 4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit BTB PF00651.31 KOS22387.1 - 1.3e-06 28.6 0.0 2.2e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 BTB/POZ domain Lyase_8 PF02278.18 KOS22388.1 - 1.4e-54 185.3 0.6 2e-54 184.8 0.6 1.3 1 0 0 1 1 1 1 Polysaccharide lyase family 8, super-sandwich domain Lyase_8_N PF08124.11 KOS22388.1 - 1.6e-11 43.8 0.0 2.4e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain Lyase_8_C PF02884.17 KOS22388.1 - 0.0092 16.4 0.0 0.023 15.1 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide lyase family 8, C-terminal beta-sandwich domain Amidase PF01425.21 KOS22389.1 - 6e-57 193.6 1.0 1.7e-46 159.2 1.3 3.0 1 1 1 2 2 2 2 Amidase NAD_binding_10 PF13460.6 KOS22390.1 - 0.00012 22.1 0.0 0.00026 20.9 0.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 KOS22390.1 - 0.0018 17.5 0.0 0.008 15.4 0.0 1.9 2 0 0 2 2 2 1 Male sterility protein Epimerase PF01370.21 KOS22390.1 - 0.017 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 KOS22390.1 - 0.019 15.2 0.0 0.029 14.6 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 KOS22390.1 - 0.025 13.7 0.0 0.033 13.3 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 KOS22390.1 - 0.026 14.6 0.0 0.042 14.0 0.0 1.3 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus KR PF08659.10 KOS22390.1 - 0.065 13.1 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 KR domain FAM76 PF16046.5 KOS22391.1 - 0.038 13.3 9.5 0.055 12.8 9.5 1.2 1 0 0 1 1 1 0 FAM76 protein Rxt3 PF08642.10 KOS22391.1 - 1.9 9.3 5.2 0.58 10.9 1.2 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 SpoIIP PF07454.11 KOS22391.1 - 2.4 7.6 9.0 0.13 11.7 2.8 1.8 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 KOS22391.1 - 3.4 7.7 16.5 0.31 11.1 8.6 2.2 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4094 PF13334.6 KOS22391.1 - 4.5 7.8 0.0 4.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Spore_coat_CotO PF14153.6 KOS22391.1 - 5.3 6.9 21.4 0.22 11.4 11.6 2.2 2 0 0 2 2 2 0 Spore coat protein CotO CTP_transf_1 PF01148.20 KOS22392.1 - 5.4e-80 269.0 26.6 6.9e-80 268.6 26.6 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family Stanniocalcin PF03298.13 KOS22393.1 - 0.24 10.7 1.8 0.74 9.1 0.0 2.2 2 1 1 3 3 3 0 Stanniocalcin family DUF3636 PF12331.8 KOS22394.1 - 7.2e-37 126.5 0.0 1.2e-36 125.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) Thiolase_N PF00108.23 KOS22395.1 - 1.2e-66 224.7 0.4 1.6e-66 224.3 0.4 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS22395.1 - 1.4e-40 137.7 0.2 3.8e-40 136.4 0.2 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 KOS22395.1 - 0.046 13.3 3.0 0.1 12.2 1.6 2.1 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 KOS22395.1 - 0.22 11.4 1.1 20 5.1 0.1 2.5 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Sulfate_transp PF00916.20 KOS22396.1 - 2.5e-78 263.5 12.8 3.5e-78 263.0 12.8 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 KOS22396.1 - 1.5e-16 60.0 0.0 3.1e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 KOS22396.1 - 0.016 15.6 3.7 0.016 15.6 3.7 3.0 3 1 0 3 3 3 0 Molybdate transporter of MFS superfamily GHL6 PF14871.6 KOS22396.1 - 0.11 12.7 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Spt20 PF12090.8 KOS22397.1 - 4.7e-48 163.8 0.0 4.7e-48 163.8 0.0 7.1 3 1 1 5 5 5 2 Spt20 family Aminotran_3 PF00202.21 KOS22399.1 - 4.2e-105 351.7 0.0 5.4e-105 351.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III ATG27 PF09451.10 KOS22400.1 - 1.6e-95 320.0 0.0 1.9e-95 319.7 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 KOS22400.1 - 0.0011 19.1 0.1 0.13 12.4 0.1 2.9 3 0 0 3 3 3 1 Cation-independent mannose-6-phosphate receptor repeat LRR_6 PF13516.6 KOS22401.1 - 0.00029 20.6 0.2 0.091 12.9 0.0 2.9 2 0 0 2 2 2 2 Leucine Rich repeat LRR_4 PF12799.7 KOS22401.1 - 0.18 12.2 2.5 24 5.5 0.1 3.1 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 KOS22401.1 - 2.2 9.2 5.2 14 6.7 0.1 3.6 3 0 0 3 3 3 0 Leucine Rich Repeat F-box PF00646.33 KOS22402.1 - 0.0018 18.1 0.3 0.0051 16.7 0.3 1.8 1 0 0 1 1 1 1 F-box domain Hexapep PF00132.24 KOS22403.1 - 6.7e-08 32.0 3.7 0.0063 16.2 0.8 2.9 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 KOS22403.1 - 3.4e-05 24.3 0.0 7.2e-05 23.2 0.0 1.6 2 0 0 2 2 2 1 MobA-like NTP transferase domain DUF4954 PF16314.5 KOS22403.1 - 0.00019 19.7 1.8 0.05 11.7 0.2 1.7 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) Fucokinase PF07959.12 KOS22403.1 - 0.00048 19.2 2.9 0.0056 15.7 2.8 2.0 1 1 0 1 1 1 1 L-fucokinase NTP_transferase PF00483.23 KOS22403.1 - 0.025 14.1 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 Nucleotidyl transferase Hexapep_2 PF14602.6 KOS22403.1 - 0.077 12.8 10.0 2.9 7.7 0.2 3.5 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase Pet191_N PF10203.9 KOS22403.1 - 0.19 12.1 4.0 2.2 8.7 1.0 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 zf-C2H2 PF00096.26 KOS22404.1 - 1.8e-05 24.9 17.2 0.0061 17.0 7.4 2.9 2 1 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS22404.1 - 0.001 19.7 12.8 0.067 14.1 0.4 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 KOS22404.1 - 0.016 15.6 1.6 0.016 15.6 1.6 3.4 3 0 0 3 3 3 0 Zinc-finger double domain FOXP-CC PF16159.5 KOS22404.1 - 0.054 14.1 1.7 0.082 13.6 1.0 1.6 1 1 0 1 1 1 0 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 KOS22404.1 - 3.7 7.7 9.2 0.58 10.2 0.2 3.0 2 1 0 2 2 2 0 C2H2-type zinc finger RdRP PF05183.12 KOS22405.1 - 6.2e-178 593.1 0.0 9.4e-93 311.8 0.0 2.1 2 0 0 2 2 2 2 RNA dependent RNA polymerase Abhydrolase_6 PF12697.7 KOS22406.1 - 6.3e-10 40.0 6.8 6.3e-10 40.0 6.8 2.5 2 1 0 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS22406.1 - 7.6e-08 32.3 0.0 3.6e-07 30.1 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS22406.1 - 0.00047 19.5 0.0 0.00086 18.6 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 KOS22406.1 - 0.0023 17.6 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 KOS22406.1 - 0.11 12.0 0.0 11 5.4 0.0 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family RRM_1 PF00076.22 KOS22407.1 - 3.5e-09 36.3 0.0 1.8e-08 34.1 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CMS1 PF14617.6 KOS22408.1 - 4.5e-77 258.8 1.0 4.9e-77 258.7 1.0 1.0 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 KOS22408.1 - 4.5e-07 29.8 0.0 5.9e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase CM_2 PF01817.21 KOS22408.1 - 0.1 13.0 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Chorismate mutase type II SH3_1 PF00018.28 KOS22409.1 - 1.8e-16 59.4 0.0 3.5e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 KOS22409.1 - 8.6e-12 44.6 0.0 1.4e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOS22409.1 - 8e-11 41.6 0.0 1.2e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SHOCT PF09851.9 KOS22409.1 - 0.18 11.5 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 Short C-terminal domain Pex14_N PF04695.13 KOS22409.1 - 3.5 8.3 12.8 6.2 7.5 3.6 2.2 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MmgE_PrpD PF03972.14 KOS22410.1 - 7.8e-146 486.1 0.0 9.2e-146 485.8 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family DNA_photolyase PF00875.18 KOS22411.1 - 1.7e-14 54.2 0.0 2.6e-14 53.6 0.0 1.2 1 0 0 1 1 1 1 DNA photolyase FAD_binding_7 PF03441.14 KOS22412.1 - 1.6e-44 151.8 0.2 2.3e-44 151.3 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain of DNA photolyase MFS_1 PF07690.16 KOS22413.1 - 4e-27 95.1 35.8 7.5e-14 51.4 18.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS22413.1 - 7.6e-11 41.5 6.6 2.5e-06 26.6 0.1 2.1 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 KOS22413.1 - 0.77 8.5 17.5 0.048 12.5 6.8 2.4 3 0 0 3 3 3 0 Sugar (and other) transporter OATP PF03137.20 KOS22413.1 - 2.7 6.2 10.3 2.1 6.6 1.1 2.8 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Methyltransf_25 PF13649.6 KOS22414.1 - 4.5e-33 113.8 0.0 4.4e-17 62.6 0.0 2.6 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22414.1 - 1.6e-32 112.0 0.0 8.5e-16 58.4 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 KOS22414.1 - 1.5e-24 86.7 0.0 2.4e-14 53.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22414.1 - 4.6e-21 75.2 0.0 1.8e-10 40.8 0.0 2.6 2 1 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22414.1 - 1.6e-16 60.8 0.0 2.5e-09 37.7 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain MetW PF07021.12 KOS22414.1 - 2.6e-12 46.7 0.0 4.2e-06 26.5 0.0 2.2 2 0 0 2 2 2 2 Methionine biosynthesis protein MetW Ubie_methyltran PF01209.18 KOS22414.1 - 8.1e-12 45.0 0.0 2.3e-06 27.1 0.0 2.3 2 0 0 2 2 2 2 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KOS22414.1 - 3.6e-09 36.3 0.0 6.7e-07 28.9 0.0 2.1 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 KOS22414.1 - 1e-06 28.3 0.0 3.6e-06 26.5 0.0 1.7 2 0 0 2 2 2 1 Tellurite resistance protein TehB PCMT PF01135.19 KOS22414.1 - 1e-06 28.7 0.0 0.011 15.4 0.0 2.3 2 0 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) NodS PF05401.11 KOS22414.1 - 2.3e-06 27.3 0.0 0.00037 20.2 0.0 2.2 2 0 0 2 2 2 1 Nodulation protein S (NodS) MTS PF05175.14 KOS22414.1 - 7.4e-06 25.6 0.0 0.022 14.3 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase small domain DREV PF05219.12 KOS22414.1 - 3e-05 23.2 0.0 0.051 12.7 0.0 2.6 3 0 0 3 3 3 2 DREV methyltransferase FtsJ PF01728.19 KOS22414.1 - 4.6e-05 23.6 0.0 0.00072 19.7 0.0 2.1 2 0 0 2 2 2 1 FtsJ-like methyltransferase GidB PF02527.15 KOS22414.1 - 0.00015 21.2 0.1 0.11 11.8 0.0 2.2 2 0 0 2 2 2 2 rRNA small subunit methyltransferase G Methyltransf_18 PF12847.7 KOS22414.1 - 0.00021 21.3 0.0 0.05 13.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS22414.1 - 0.00033 20.7 0.0 0.11 12.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain DUF938 PF06080.12 KOS22414.1 - 0.0014 18.5 0.0 0.98 9.1 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF938) PrmA PF06325.13 KOS22414.1 - 0.0021 17.5 0.0 0.099 12.0 0.0 2.2 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_15 PF09445.10 KOS22414.1 - 0.0022 17.6 0.0 0.015 14.9 0.0 2.0 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase TPMT PF05724.11 KOS22414.1 - 0.0034 17.1 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) UDPG_MGDP_dh_N PF03721.14 KOS22414.1 - 0.0073 15.9 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Methyltr_RsmB-F PF01189.17 KOS22414.1 - 0.011 15.4 0.0 0.28 10.8 0.0 2.4 3 0 0 3 3 2 0 16S rRNA methyltransferase RsmB/F RrnaAD PF00398.20 KOS22414.1 - 0.015 14.4 0.0 2.2 7.3 0.0 2.2 2 0 0 2 2 2 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 KOS22414.1 - 0.031 13.8 0.0 6.7 6.1 0.0 2.6 3 0 0 3 3 3 0 Putative methyltransferase TetR_N PF00440.23 KOS22414.1 - 0.081 12.7 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family DUF4129 PF13559.6 KOS22414.1 - 0.089 13.1 1.5 1.6 9.1 1.5 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4129) SIS_2 PF13580.6 KOS22414.1 - 0.18 11.9 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 SIS domain CheR PF01739.18 KOS22414.1 - 0.18 11.3 0.0 16 4.9 0.0 2.7 2 1 1 3 3 3 0 CheR methyltransferase, SAM binding domain Amidase PF01425.21 KOS22415.1 - 1.4e-46 159.4 5.0 1.5e-45 156.0 1.7 2.6 2 1 0 2 2 2 2 Amidase Mob1_phocein PF03637.17 KOS22416.1 - 1.5e-39 135.8 0.0 3e-39 134.8 0.0 1.5 1 1 0 1 1 1 1 Mob1/phocein family Ank_2 PF12796.7 KOS22417.1 - 4.3e-14 52.9 0.0 1.5e-05 25.5 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS22417.1 - 2.6e-13 48.8 0.5 0.00026 21.2 0.0 5.8 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 KOS22417.1 - 4.5e-13 49.0 4.2 0.008 16.6 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 KOS22417.1 - 8.6e-11 41.9 0.1 0.0019 18.5 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeats (many copies) CitMHS PF03600.16 KOS22417.1 - 1.3e-10 41.0 17.3 1.9e-10 40.4 17.3 1.2 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.15 KOS22417.1 - 1.3e-10 41.2 14.2 4.1e-08 33.0 7.5 2.1 2 0 0 2 2 2 2 Arsenical pump membrane protein Ank_4 PF13637.6 KOS22417.1 - 1.8e-10 41.1 3.4 6.6e-05 23.4 0.1 4.8 4 2 1 5 5 5 2 Ankyrin repeats (many copies) DSS1_SEM1 PF05160.13 KOS22419.1 - 1.7e-23 82.4 13.5 1.7e-23 82.4 13.5 1.5 2 0 0 2 2 2 1 DSS1/SEM1 family Cwf_Cwc_15 PF04889.12 KOS22419.1 - 0.16 11.7 9.6 0.17 11.6 9.6 1.0 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3808 PF10300.9 KOS22420.1 - 2.6e-127 425.5 0.0 3.5e-127 425.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3808) TPR_19 PF14559.6 KOS22420.1 - 0.0041 17.6 1.3 5 7.7 0.1 3.8 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22420.1 - 1.8 8.9 4.8 1.2 9.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Mpv17_PMP22 PF04117.12 KOS22421.1 - 1.7e-21 76.2 0.2 1.7e-21 76.2 0.2 1.9 2 0 0 2 2 2 1 Mpv17 / PMP22 family PGK PF00162.19 KOS22422.1 - 4.7e-151 503.0 1.8 5.4e-151 502.8 1.8 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase PA PF02225.22 KOS22422.1 - 0.0083 16.1 0.1 0.075 13.1 0.0 2.6 3 1 1 4 4 4 1 PA domain PrpR_N PF06506.11 KOS22422.1 - 0.055 13.0 1.1 6.4 6.3 0.1 3.3 3 1 0 3 3 3 0 Propionate catabolism activator DUF3530 PF12048.8 KOS22422.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Kinesin PF00225.23 KOS22423.1 - 1.4e-56 191.8 0.0 4.7e-56 190.1 0.0 1.8 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 KOS22423.1 - 4.4e-10 39.7 0.0 3.1e-09 36.9 0.0 2.3 2 0 0 2 2 2 1 Microtubule binding TFIIA PF03153.13 KOS22423.1 - 0.023 14.7 6.4 0.036 14.1 6.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit bZIP_1 PF00170.21 KOS22423.1 - 0.037 14.1 3.4 3.5 7.8 0.3 2.8 2 0 0 2 2 2 0 bZIP transcription factor DUF1192 PF06698.11 KOS22423.1 - 0.057 13.5 14.2 0.49 10.5 7.3 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DivIC PF04977.15 KOS22423.1 - 0.067 13.0 8.9 0.096 12.5 3.7 2.8 2 0 0 2 2 2 0 Septum formation initiator APC_N_CC PF16689.5 KOS22423.1 - 0.76 9.9 3.7 0.68 10.0 0.2 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain TSC22 PF01166.18 KOS22423.1 - 0.88 9.9 5.1 17 5.8 0.4 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family ADIP PF11559.8 KOS22423.1 - 9.8 6.2 11.1 1.2 9.2 4.1 2.8 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Peptidase_S24 PF00717.23 KOS22425.1 - 1.7e-07 31.1 0.1 2.5e-07 30.6 0.1 1.3 1 0 0 1 1 1 1 Peptidase S24-like DUF2781 PF10914.8 KOS22426.1 - 0.053 13.9 0.2 3 8.3 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2781) Tad PF13400.6 KOS22426.1 - 0.44 10.9 6.7 0.23 11.8 2.3 2.4 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like HemY_N PF07219.13 KOS22426.1 - 1.2 9.3 5.5 8.3 6.7 0.4 3.0 2 1 1 3 3 3 0 HemY protein N-terminus Spindle_Spc25 PF08234.12 KOS22427.1 - 1.4e-24 86.1 0.1 3.1e-24 84.9 0.1 1.6 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 Spc7 PF08317.11 KOS22427.1 - 0.0087 15.0 8.2 0.012 14.6 7.5 1.4 1 1 0 1 1 1 1 Spc7 kinetochore protein Atg14 PF10186.9 KOS22427.1 - 0.75 8.8 7.8 1 8.4 7.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 KOS22427.1 - 1.2 9.6 16.7 13 6.3 1.3 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 KOS22427.1 - 5.4 6.3 12.3 8.9 5.6 12.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Rrn6 PF10214.9 KOS22428.1 - 4.5e-120 402.6 0.0 5.4e-120 402.4 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor zinc_ribbon_6 PF14599.6 KOS22429.1 - 3.2e-24 84.7 1.1 3.2e-24 84.7 1.1 3.7 4 1 0 4 4 2 1 Zinc-ribbon zf-CHY PF05495.12 KOS22429.1 - 7.9e-21 74.3 21.2 7.9e-21 74.3 21.2 3.6 2 1 1 3 3 1 1 CHY zinc finger zf-RING_2 PF13639.6 KOS22429.1 - 1.2e-08 35.2 9.7 1.2e-08 35.2 9.7 5.5 3 1 3 6 6 3 1 Ring finger domain zf-RING_UBOX PF13445.6 KOS22429.1 - 4.5e-07 29.8 4.3 4.5e-07 29.8 4.3 5.2 5 2 0 5 5 4 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 KOS22429.1 - 6.1e-07 29.2 7.2 6.1e-07 29.2 7.2 4.6 5 0 0 5 5 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 KOS22429.1 - 4.2e-06 26.5 6.8 4.2e-06 26.5 6.8 5.7 2 2 3 5 5 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 KOS22429.1 - 1.1e-05 25.3 6.5 1.1e-05 25.3 6.5 6.1 2 1 3 5 5 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 KOS22429.1 - 2.4e-05 24.1 4.9 2.4e-05 24.1 4.9 5.1 2 2 3 5 5 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 KOS22429.1 - 0.00028 20.7 8.6 0.00028 20.7 8.6 5.8 2 1 4 6 6 4 1 Prokaryotic RING finger family 4 TFIIA PF03153.13 KOS22429.1 - 0.0065 16.5 15.3 0.0065 16.5 15.3 1.6 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit zf-RING_11 PF17123.5 KOS22429.1 - 0.0089 15.8 2.0 0.0089 15.8 2.0 4.4 4 0 0 4 4 4 1 RING-like zinc finger Nop14 PF04147.12 KOS22429.1 - 0.031 12.5 13.5 0.039 12.2 13.5 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 KOS22429.1 - 0.15 12.3 20.1 0.31 11.3 20.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 KOS22429.1 - 3.6 7.1 16.5 0.096 12.3 10.3 1.5 2 0 0 2 2 2 0 PPP4R2 Cwf_Cwc_15 PF04889.12 KOS22429.1 - 5.2 6.7 25.6 15 5.2 25.6 1.7 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Cnd2 PF05786.14 KOS22429.1 - 6.8 5.2 17.0 11 4.6 17.0 1.2 1 0 0 1 1 1 0 Condensin complex subunit 2 MOZART1 PF12554.8 KOS22430.1 - 3e-24 84.5 0.8 3.5e-24 84.3 0.8 1.1 1 0 0 1 1 1 1 Mitotic-spindle organizing gamma-tubulin ring associated DUF2785 PF10978.8 KOS22430.1 - 0.061 13.1 0.1 0.062 13.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) Coa1 PF08695.10 KOS22431.1 - 8e-42 141.7 0.0 1e-41 141.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 PITH PF06201.13 KOS22433.1 - 3.9e-39 134.3 0.0 4.7e-39 134.0 0.0 1.1 1 0 0 1 1 1 1 PITH domain Ribosomal_L3 PF00297.22 KOS22434.1 - 6.8e-17 61.5 2.1 3.8e-12 45.9 0.7 2.1 1 1 1 2 2 2 2 Ribosomal protein L3 Peptidase_S8 PF00082.22 KOS22434.1 - 0.086 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Subtilase family HGWP PF03578.15 KOS22434.1 - 0.14 11.6 0.2 16 5.1 0.1 2.7 2 0 0 2 2 2 0 HGWP repeat SPX PF03105.19 KOS22435.1 - 5.8e-20 72.6 17.2 1.3e-09 38.5 1.3 3.3 1 1 2 3 3 3 3 SPX domain Ank_4 PF13637.6 KOS22435.1 - 1.5e-08 35.0 1.8 5.1e-07 30.1 0.1 3.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS22435.1 - 8.3e-08 32.4 0.9 0.0011 19.2 0.0 2.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS22435.1 - 2.3e-07 31.3 1.2 1.1e-06 29.1 0.1 2.5 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS22435.1 - 0.018 15.5 0.3 21 6.1 0.0 4.1 4 0 0 4 4 4 0 Ankyrin repeat Ank PF00023.30 KOS22435.1 - 0.1 13.1 0.9 0.84 10.2 0.1 2.8 3 0 0 3 3 3 0 Ankyrin repeat CUE PF02845.16 KOS22436.1 - 3.2e-13 49.1 0.0 5.7e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 CUE domain AntA PF08346.12 KOS22436.1 - 0.1 13.1 0.2 0.21 12.2 0.2 1.5 1 0 0 1 1 1 0 AntA/AntB antirepressor Complex1_LYR PF05347.15 KOS22437.1 - 7.3e-08 32.3 0.0 1.5e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Complex 1 protein (LYR family) DUF599 PF04654.12 KOS22438.1 - 0.048 13.1 2.1 0.087 12.2 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Glyco_hydro_9 PF00759.19 KOS22438.1 - 0.31 10.4 11.0 1.4 8.3 4.9 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 9 BLM10_mid PF16507.5 KOS22439.1 - 9.5e-197 654.8 0.0 1.5e-196 654.2 0.0 1.3 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3437 PF11919.8 KOS22439.1 - 1.5e-29 101.7 0.0 4.9e-29 100.1 0.0 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3437) BLM10_N PF16547.5 KOS22439.1 - 4.9e-20 71.6 0.1 1.3e-19 70.2 0.1 1.8 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal HEAT PF02985.22 KOS22439.1 - 0.0013 18.8 0.1 6.2 7.4 0.0 5.4 5 0 0 5 5 5 1 HEAT repeat IFRD PF05004.13 KOS22439.1 - 2.4 7.2 6.0 10 5.1 0.0 2.7 3 0 0 3 3 3 0 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 KOS22439.1 - 3 8.4 6.9 5.5 7.6 0.0 4.7 6 0 0 6 6 6 0 HEAT-like repeat A_deaminase PF00962.22 KOS22440.1 - 7.5e-23 81.4 0.0 4.8e-20 72.1 0.0 2.8 1 1 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase_N PF08451.11 KOS22440.1 - 0.041 14.2 0.0 0.16 12.3 0.0 2.0 1 1 0 1 1 1 0 Adenosine/AMP deaminase N-terminal Chalcone_2 PF16035.5 KOS22441.1 - 8.5e-78 260.8 0.0 1.1e-77 260.4 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 KOS22441.1 - 0.00026 21.1 0.0 0.067 13.3 0.1 2.3 1 1 1 2 2 2 2 Chalcone isomerase-like Melibiase PF02065.18 KOS22442.1 - 1.2e-136 455.2 0.0 1.6e-136 454.9 0.0 1.1 1 0 0 1 1 1 1 Melibiase Glyco_hydro_36N PF16875.5 KOS22442.1 - 8.5e-69 231.9 0.0 1.3e-68 231.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 N-terminal domain Glyco_hydro_36C PF16874.5 KOS22442.1 - 4.3e-22 78.4 0.0 8.1e-22 77.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 36 C-terminal domain GHL10 PF02638.15 KOS22442.1 - 0.00027 20.1 0.0 0.00042 19.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase-like 10 LRR_6 PF13516.6 KOS22443.1 - 4.1e-17 60.7 24.5 0.0088 16.0 0.0 11.2 12 0 0 12 12 12 6 Leucine Rich repeat F-box-like PF12937.7 KOS22443.1 - 1.3e-13 50.6 2.3 3.5e-13 49.2 0.7 2.7 3 0 0 3 3 3 1 F-box-like LRR_4 PF12799.7 KOS22443.1 - 2.3e-10 40.6 13.4 0.16 12.4 0.0 7.3 5 1 4 9 9 9 4 Leucine Rich repeats (2 copies) F-box PF00646.33 KOS22443.1 - 5.9e-06 26.0 0.5 5.9e-06 26.0 0.5 2.5 3 0 0 3 3 3 1 F-box domain DUF1699 PF08004.11 KOS22443.1 - 0.037 13.7 0.3 0.52 10.0 0.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1699) LRR_1 PF00560.33 KOS22443.1 - 0.6 10.9 21.5 23 6.0 0.0 8.7 9 1 0 9 9 9 0 Leucine Rich Repeat Pkinase PF00069.25 KOS22444.1 - 9.7e-27 94.0 0.0 2.5e-25 89.3 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22444.1 - 1.4e-18 67.1 0.0 2.5e-18 66.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FUSC PF04632.12 KOS22444.1 - 0.11 11.0 0.3 0.17 10.4 0.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Nucleo_P87 PF07267.11 KOS22444.1 - 0.99 8.2 6.1 1.6 7.5 6.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 PBP1_TM PF14812.6 KOS22444.1 - 5.4 7.5 6.3 1.2 9.5 0.8 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pox_Ag35 PF03286.14 KOS22444.1 - 7.4 6.3 10.3 0.22 11.3 3.3 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein SRP40_C PF05022.12 KOS22445.1 - 9.5e-22 77.7 0.7 3e-21 76.1 0.7 1.9 1 0 0 1 1 1 1 SRP40, C-terminal domain SEEEED PF14797.6 KOS22445.1 - 0.0019 18.4 87.1 0.029 14.5 49.8 2.7 1 1 1 2 2 2 2 Serine-rich region of AP3B1, clathrin-adaptor complex CDC27 PF09507.10 KOS22445.1 - 0.019 14.4 44.5 0.026 13.9 44.5 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hamartin PF04388.12 KOS22445.1 - 0.41 9.2 23.1 0.45 9.1 23.1 1.2 1 0 0 1 1 1 0 Hamartin protein Atrophin-1 PF03154.15 KOS22445.1 - 0.54 8.5 39.6 0.64 8.2 39.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family Cwf_Cwc_15 PF04889.12 KOS22445.1 - 7.3 6.2 58.6 3.1 7.4 41.9 3.0 1 1 1 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-C3HC PF07967.13 KOS22446.1 - 4e-26 91.6 0.1 5.2e-21 75.1 0.5 2.3 1 1 0 2 2 2 2 C3HC zinc finger-like Rsm1 PF08600.10 KOS22446.1 - 3.3e-25 88.1 1.7 9.7e-25 86.6 0.0 2.4 2 1 0 2 2 2 1 Rsm1-like BIR PF00653.21 KOS22446.1 - 7e-05 23.4 0.2 0.0095 16.6 0.1 2.7 2 1 1 3 3 3 1 Inhibitor of Apoptosis domain APH PF01636.23 KOS22447.1 - 6.1e-12 46.0 1.1 1.3e-11 44.9 1.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family PTPLA PF04387.14 KOS22448.1 - 4.9e-53 179.2 8.0 4.9e-53 179.2 8.0 1.6 2 0 0 2 2 2 1 Protein tyrosine phosphatase-like protein, PTPLA Amidohydro_2 PF04909.14 KOS22449.1 - 1.7e-30 106.8 0.1 4.8e-30 105.3 0.1 1.6 1 1 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 KOS22449.1 - 0.019 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 TatD related DNase DIOX_N PF14226.6 KOS22450.1 - 2.6e-28 99.2 0.1 4.3e-28 98.4 0.1 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 KOS22450.1 - 3.2e-18 66.1 0.0 5.8e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily GCV_T PF01571.21 KOS22451.1 - 1.2e-07 31.3 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain DnaJ PF00226.31 KOS22452.1 - 2.6e-13 49.9 0.1 2.6e-13 49.9 0.1 2.4 2 0 0 2 2 2 1 DnaJ domain Exonuc_VII_L PF02601.15 KOS22452.1 - 0.1 12.1 8.9 0.11 12.0 8.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Asp-B-Hydro_N PF05279.11 KOS22452.1 - 0.42 10.6 18.1 0.63 10.1 18.1 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 KOS22452.1 - 0.51 9.0 9.2 0.62 8.8 9.2 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 KOS22452.1 - 0.53 8.1 8.9 0.63 7.9 8.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BAF1_ABF1 PF04684.13 KOS22452.1 - 0.69 8.9 13.5 0.84 8.6 13.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Neur_chan_memb PF02932.16 KOS22452.1 - 4.4 7.3 7.9 6.2 6.8 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AA_permease_2 PF13520.6 KOS22454.1 - 6.3e-57 193.3 48.4 8.3e-57 192.9 48.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS22454.1 - 4.6e-14 51.9 38.9 6.5e-14 51.4 38.9 1.1 1 0 0 1 1 1 1 Amino acid permease Asparaginase_2 PF01112.18 KOS22455.1 - 2.6e-60 204.1 7.2 3.4e-60 203.6 7.2 1.0 1 0 0 1 1 1 1 Asparaginase AMP-binding PF00501.28 KOS22457.1 - 1.9e-66 224.4 0.0 2.4e-66 224.1 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS22457.1 - 4.9e-12 46.6 1.5 1.7e-11 44.9 1.5 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Goodbye PF17109.5 KOS22458.1 - 2.3e-27 95.8 0.0 5.8e-27 94.6 0.0 1.7 1 0 0 1 1 1 1 fungal STAND N-terminal Goodbye domain TPR_1 PF00515.28 KOS22458.1 - 1.4e-12 46.8 0.5 0.00061 19.5 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22458.1 - 1.6e-11 43.4 8.1 0.0045 17.0 0.1 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22458.1 - 8.9e-10 38.0 3.0 0.0039 17.3 0.0 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22458.1 - 2.6e-08 34.0 11.7 0.008 16.4 0.6 5.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 KOS22458.1 - 4.3e-08 33.7 8.1 0.0031 18.1 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat AAA_16 PF13191.6 KOS22458.1 - 2.7e-06 27.9 1.1 1.9e-05 25.1 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain TPR_19 PF14559.6 KOS22458.1 - 1.1e-05 25.8 14.7 2.9e-05 24.5 0.6 5.6 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOS22458.1 - 5.5e-05 23.5 4.6 0.012 16.2 0.0 5.7 5 0 0 5 5 5 1 Tetratricopeptide repeat AAA_22 PF13401.6 KOS22458.1 - 0.00015 22.1 0.0 0.00097 19.4 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 KOS22458.1 - 0.00042 20.3 0.5 0.069 13.2 0.0 3.9 4 1 0 4 4 4 1 AAA domain (dynein-related subfamily) NACHT PF05729.12 KOS22458.1 - 0.00046 20.1 0.0 0.0036 17.2 0.0 2.5 3 0 0 3 3 3 1 NACHT domain TPR_7 PF13176.6 KOS22458.1 - 0.00091 19.1 4.2 3 8.1 0.5 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS22458.1 - 0.00097 19.8 18.3 2 9.4 0.0 7.7 6 3 3 9 9 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 KOS22458.1 - 0.0026 17.4 0.1 0.07 12.8 0.0 3.2 3 0 0 3 3 3 1 TPR repeat TPR_17 PF13431.6 KOS22458.1 - 0.0094 16.3 1.6 0.14 12.6 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat BTAD PF03704.17 KOS22458.1 - 0.027 14.9 7.9 4.4 7.7 1.0 4.0 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_20 PF14561.6 KOS22458.1 - 0.035 14.4 1.2 0.22 11.9 0.1 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat RNA_helicase PF00910.22 KOS22458.1 - 0.075 13.4 0.0 0.28 11.6 0.0 2.0 2 0 0 2 2 1 0 RNA helicase ANAPC3 PF12895.7 KOS22458.1 - 0.1 12.8 4.1 2.4 8.5 0.1 4.1 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 KOS22458.1 - 0.54 10.2 5.5 14 5.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat DJ-1_PfpI PF01965.24 KOS22459.1 - 6.2e-20 71.7 0.0 8.1e-20 71.3 0.0 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family MFS_1 PF07690.16 KOS22462.1 - 3e-10 39.6 50.1 1.8e-09 37.0 49.1 2.7 2 1 1 3 3 3 1 Major Facilitator Superfamily Mito_carr PF00153.27 KOS22463.1 - 3e-52 174.5 4.0 1.2e-20 73.2 0.3 4.0 4 0 0 4 4 4 4 Mitochondrial carrier protein DUF2370 PF10176.9 KOS22465.1 - 7.7e-89 297.2 0.0 1.7e-88 296.1 0.0 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF2370) PCMT PF01135.19 KOS22466.1 - 6.4e-42 143.7 0.0 8.6e-42 143.3 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 KOS22466.1 - 1.1e-05 25.3 0.0 1.5e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22466.1 - 0.00083 20.0 0.0 0.0014 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 KOS22466.1 - 0.0011 18.9 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS22466.1 - 0.014 14.7 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 KOS22466.1 - 0.03 15.0 0.0 0.048 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 KOS22466.1 - 0.081 12.7 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 KOS22466.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_3 PF01596.17 KOS22466.1 - 0.17 11.0 0.0 0.29 10.3 0.0 1.5 2 0 0 2 2 2 0 O-methyltransferase Methyltransf_4 PF02390.17 KOS22466.1 - 0.23 10.9 0.0 0.31 10.5 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase RrnaAD PF00398.20 KOS22466.1 - 0.3 10.1 0.0 0.39 9.7 0.0 1.1 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Exo_endo_phos PF03372.23 KOS22467.1 - 3.7e-10 39.7 1.2 2e-09 37.3 1.2 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 KOS22467.1 - 0.054 13.3 0.0 0.82 9.5 0.0 2.2 2 0 0 2 2 2 0 Endonuclease-reverse transcriptase DPPIV_N PF00930.21 KOS22468.1 - 1.3e-103 346.5 0.9 1.3e-103 346.5 0.9 1.5 2 0 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 KOS22468.1 - 3.3e-38 131.3 0.8 5.9e-38 130.5 0.8 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOS22468.1 - 0.015 15.9 0.4 0.015 15.9 0.4 2.3 2 2 1 3 3 3 0 Alpha/beta hydrolase family Bac_chlorC PF02043.17 KOS22469.1 - 0.067 13.2 1.1 0.12 12.4 1.1 1.4 1 0 0 1 1 1 0 Bacteriochlorophyll C binding protein Cu-oxidase_3 PF07732.15 KOS22470.1 - 8.2e-41 138.8 0.7 1e-38 132.0 0.1 2.7 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 KOS22470.1 - 3e-29 101.5 5.6 3.9e-28 97.9 0.3 3.1 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase PF00394.22 KOS22470.1 - 1.7e-13 51.0 0.0 7.4e-12 45.7 0.0 2.4 2 0 0 2 2 2 1 Multicopper oxidase Phosphoesterase PF04185.14 KOS22471.1 - 8.7e-56 189.6 3.9 1.1e-55 189.3 3.9 1.1 1 0 0 1 1 1 1 Phosphoesterase family DUF5353 PF17304.2 KOS22472.1 - 5.8e-10 38.8 1.7 9.7e-10 38.1 1.7 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5353) Acetyltransf_1 PF00583.25 KOS22473.1 - 1.8e-05 24.9 0.0 2.4e-05 24.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS22473.1 - 3.7e-05 23.7 0.0 6.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22473.1 - 0.00027 21.3 0.0 0.00049 20.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOS22473.1 - 0.0092 16.1 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 KOS22473.1 - 0.045 13.8 0.0 0.52 10.4 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain CENP-L PF13092.6 KOS22474.1 - 9.4e-49 165.8 0.0 1.1e-47 162.3 0.0 2.0 2 0 0 2 2 2 1 Kinetochore complex Sim4 subunit Fta1 NAD_binding_10 PF13460.6 KOS22475.1 - 4e-11 43.1 0.0 1.1e-10 41.7 0.0 1.7 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 KOS22475.1 - 2e-06 27.4 0.0 3.2e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 KOS22475.1 - 2.9e-05 24.2 0.0 0.00013 22.1 0.1 1.9 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus 3Beta_HSD PF01073.19 KOS22475.1 - 0.00012 21.2 0.1 0.00018 20.6 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOS22475.1 - 0.00025 20.3 0.0 0.0038 16.4 0.0 2.1 2 0 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 KOS22475.1 - 0.00092 18.4 0.0 0.0013 17.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NmrA PF05368.13 KOS22475.1 - 0.0023 17.5 0.0 0.0029 17.2 0.0 1.2 1 0 0 1 1 1 1 NmrA-like family RmlD_sub_bind PF04321.17 KOS22475.1 - 0.03 13.4 0.0 0.041 13.0 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Semialdhyde_dh PF01118.24 KOS22475.1 - 0.11 12.9 0.0 0.19 12.2 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain adh_short PF00106.25 KOS22475.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 KOS22475.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 KOS22475.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 KR domain Glyco_hydro_16 PF00722.21 KOS22476.1 - 3.6e-15 55.9 0.0 5.5e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 SKN1 PF03935.15 KOS22476.1 - 0.00083 17.9 0.9 0.0051 15.3 0.3 1.9 2 0 0 2 2 2 2 Beta-glucan synthesis-associated protein (SKN1) DUF89 PF01937.19 KOS22477.1 - 1.6e-114 382.6 0.0 1.9e-114 382.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 Sugar_tr PF00083.24 KOS22479.1 - 4.2e-112 375.3 15.8 5.1e-112 375.0 15.8 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS22479.1 - 6.2e-31 107.6 41.7 5.2e-29 101.3 14.2 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily TRI12 PF06609.13 KOS22479.1 - 0.00012 20.7 0.3 0.00023 19.7 0.3 1.4 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF2583 PF10762.9 KOS22479.1 - 0.81 10.1 3.5 1.9 9.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2583) T5orf172 PF10544.9 KOS22480.1 - 4.4e-19 68.9 0.0 9.6e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 T5orf172 domain MUG113 PF13455.6 KOS22480.1 - 1.4e-17 64.1 0.0 3.2e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Meiotically up-regulated gene 113 RAI16-like PF10257.9 KOS22481.1 - 1.6e-53 181.9 0.4 2.1e-53 181.5 0.4 1.1 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Promethin PF16015.5 KOS22483.1 - 1.5e-26 92.4 13.8 1.8e-26 92.1 13.8 1.1 1 0 0 1 1 1 1 Promethin DUF4404 PF14357.6 KOS22483.1 - 0.081 13.6 0.0 0.13 12.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) DUF1700 PF08006.11 KOS22483.1 - 0.51 9.8 2.9 0.67 9.5 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) CobS PF02654.15 KOS22483.1 - 4.7 7.3 11.9 6.4 6.9 11.9 1.1 1 0 0 1 1 1 0 Cobalamin-5-phosphate synthase S1-P1_nuclease PF02265.16 KOS22484.1 - 4.1e-67 226.7 0.0 4.8e-67 226.4 0.0 1.0 1 0 0 1 1 1 1 S1/P1 Nuclease DUF4535 PF15054.6 KOS22484.1 - 0.029 14.1 0.1 0.074 12.8 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4535) UQ_con PF00179.26 KOS22485.1 - 2.1e-38 131.1 0.0 2.6e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 KOS22485.1 - 4e-05 23.3 0.0 6.3e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B UBA_3 PF09288.10 KOS22485.1 - 5.1e-05 23.0 0.1 9e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain UBA PF00627.31 KOS22485.1 - 0.035 14.0 0.2 0.088 12.7 0.1 1.7 1 1 0 1 1 1 0 UBA/TS-N domain AAA PF00004.29 KOS22486.1 - 1.8e-41 141.7 0.0 3.5e-41 140.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS22486.1 - 2.8e-11 43.1 0.6 5.4e-11 42.1 0.6 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 KOS22486.1 - 4.9e-11 42.4 0.2 1.1e-10 41.3 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 KOS22486.1 - 4.2e-06 27.0 0.0 8.7e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 KOS22486.1 - 9.2e-06 26.0 0.1 0.0062 16.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOS22486.1 - 1.5e-05 24.3 0.0 2.5e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_5 PF07728.14 KOS22486.1 - 7.4e-05 22.8 0.1 0.00034 20.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOS22486.1 - 0.0003 21.2 0.1 0.0069 16.8 0.1 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 KOS22486.1 - 0.00046 20.0 0.0 0.00088 19.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 KOS22486.1 - 0.0018 18.8 0.1 0.0042 17.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_28 PF13521.6 KOS22486.1 - 0.0022 18.3 0.4 0.0089 16.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain Prot_ATP_OB_N PF17758.1 KOS22486.1 - 0.0024 17.5 0.4 0.017 14.8 0.0 2.4 2 0 0 2 2 2 1 Proteasomal ATPase OB N-terminal domain AAA_33 PF13671.6 KOS22486.1 - 0.0078 16.4 0.1 0.027 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 KOS22486.1 - 0.017 15.0 0.0 0.032 14.1 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 KOS22486.1 - 0.017 14.8 0.0 0.037 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 KOS22486.1 - 0.026 13.8 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_14 PF13173.6 KOS22486.1 - 0.027 14.5 0.0 0.055 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 KOS22486.1 - 0.053 13.9 0.0 0.099 13.0 0.0 1.5 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 KOS22486.1 - 0.056 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 KOS22486.1 - 0.058 13.3 0.1 0.6 10.0 0.1 2.4 1 1 1 2 2 2 0 NACHT domain ATPase PF06745.13 KOS22486.1 - 0.06 12.7 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 KaiC AAA_25 PF13481.6 KOS22486.1 - 0.077 12.6 1.1 0.54 9.8 0.4 2.5 1 1 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 KOS22486.1 - 0.08 12.2 0.1 0.18 11.0 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin PhoH PF02562.16 KOS22486.1 - 0.094 12.2 1.8 0.49 9.8 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein DUF2075 PF09848.9 KOS22486.1 - 0.18 11.0 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RNA_pol_Rpb1_5 PF04998.17 KOS22486.1 - 0.2 11.0 0.0 0.26 10.7 0.0 1.3 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 5 ABC_tran PF00005.27 KOS22486.1 - 0.22 12.1 0.5 0.99 9.9 0.5 2.3 1 1 0 1 1 1 0 ABC transporter AAA_24 PF13479.6 KOS22486.1 - 0.29 10.8 2.0 0.32 10.7 0.4 2.0 2 1 0 2 2 2 0 AAA domain RTC4 PF14474.6 KOS22487.1 - 2.8e-29 101.7 0.0 6.3e-29 100.6 0.0 1.6 1 0 0 1 1 1 1 RTC4-like domain Rrp44_CSD1 PF17216.3 KOS22487.1 - 0.046 13.4 0.3 0.077 12.7 0.3 1.3 1 0 0 1 1 1 0 Rrp44-like cold shock domain HTH_ABP1_N PF18107.1 KOS22487.1 - 0.14 11.9 0.6 0.33 10.7 0.6 1.6 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Dynamitin PF04912.14 KOS22488.1 - 1.3e-98 330.9 0.0 1.5e-98 330.7 0.0 1.0 1 0 0 1 1 1 1 Dynamitin Fzo_mitofusin PF04799.13 KOS22488.1 - 0.0041 16.7 1.4 0.14 11.7 0.0 2.8 3 0 0 3 3 3 1 fzo-like conserved region FH2 PF02181.23 KOS22488.1 - 0.017 14.3 0.9 0.58 9.2 0.1 2.4 3 0 0 3 3 3 0 Formin Homology 2 Domain Laminin_II PF06009.12 KOS22488.1 - 0.017 15.1 5.4 0.16 12.0 0.0 3.6 2 1 1 3 3 3 0 Laminin Domain II DUF2046 PF09755.9 KOS22488.1 - 0.083 12.1 3.4 0.53 9.5 1.1 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DHR10 PF18595.1 KOS22488.1 - 0.094 12.8 12.6 7.5 6.6 0.8 3.7 4 0 0 4 4 3 0 Designed helical repeat protein 10 domain ADIP PF11559.8 KOS22488.1 - 0.11 12.6 5.7 4.3 7.4 0.0 3.1 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DivIC PF04977.15 KOS22488.1 - 0.26 11.1 9.6 6.5 6.6 0.2 3.4 3 0 0 3 3 3 0 Septum formation initiator TPR_MLP1_2 PF07926.12 KOS22488.1 - 0.67 10.0 9.6 4.8 7.3 0.0 3.3 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF2721 PF11026.8 KOS22488.1 - 0.69 9.8 2.1 1.5 8.8 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Phage_GP20 PF06810.11 KOS22488.1 - 1 9.2 7.1 7.2 6.4 0.1 3.2 3 0 0 3 3 3 0 Phage minor structural protein GP20 THOC7 PF05615.13 KOS22488.1 - 1.4 9.2 7.2 6.7 7.0 0.4 3.1 3 0 0 3 3 3 0 Tho complex subunit 7 XhlA PF10779.9 KOS22488.1 - 1.6 9.0 9.6 0.73 10.1 0.1 3.8 3 1 1 4 4 4 0 Haemolysin XhlA DUF1192 PF06698.11 KOS22488.1 - 4.6 7.4 9.4 0.29 11.2 1.2 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) BRE1 PF08647.11 KOS22488.1 - 4.9 7.3 8.5 30 4.8 0.4 3.3 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase BST2 PF16716.5 KOS22488.1 - 7.2 7.3 6.4 59 4.3 0.1 3.5 3 1 0 3 3 3 0 Bone marrow stromal antigen 2 HWE_HK PF07536.14 KOS22488.1 - 8.4 7.2 7.4 0.95 10.2 1.3 2.6 3 0 0 3 3 2 0 HWE histidine kinase Mito_carr PF00153.27 KOS22490.1 - 1.5e-47 159.4 6.7 1.6e-18 66.4 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Epimerase PF01370.21 KOS22491.1 - 1.3e-18 67.3 0.0 1.8e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 KOS22491.1 - 3.4e-10 39.5 0.0 4.9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 KOS22491.1 - 8.6e-05 22.1 0.0 0.00013 21.5 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KOS22491.1 - 0.00012 21.2 0.0 0.00019 20.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family KR PF08659.10 KOS22491.1 - 0.069 13.1 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 KR domain Ldh_1_N PF00056.23 KOS22491.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain PP2C PF00481.21 KOS22493.1 - 5.1e-53 180.3 0.0 8.4e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_8 PF13855.6 KOS22493.1 - 4.9e-43 144.7 62.7 1.5e-11 43.9 1.3 9.5 6 2 3 10 10 10 9 Leucine rich repeat LRR_4 PF12799.7 KOS22493.1 - 1.7e-41 139.5 65.7 6.2e-06 26.5 1.9 12.1 8 1 6 14 14 14 12 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 KOS22493.1 - 1.5e-31 109.5 0.0 4.6e-31 107.9 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Ad_cyc_g-alpha PF08509.11 KOS22493.1 - 2.8e-19 68.6 3.5 6.1e-19 67.5 3.5 1.6 1 0 0 1 1 1 1 Adenylate cyclase G-alpha binding domain LRR_1 PF00560.33 KOS22493.1 - 1.5e-09 37.1 52.9 1.7 9.5 0.2 16.5 17 2 1 18 18 18 5 Leucine Rich Repeat LRR_9 PF14580.6 KOS22493.1 - 0.0052 16.3 18.4 0.041 13.4 0.6 4.6 2 1 1 4 4 4 2 Leucine-rich repeat Musclin PF11037.8 KOS22493.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Insulin-resistance promoting peptide in skeletal muscle Alpha-amylase PF00128.24 KOS22494.1 - 1.6e-118 396.1 0.1 4.4e-118 394.7 0.0 1.6 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Malt_amylase_C PF16657.5 KOS22494.1 - 2.5e-06 27.5 0.0 5.1e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Maltogenic Amylase, C-terminal domain hDGE_amylase PF14701.6 KOS22494.1 - 0.026 13.6 0.0 0.044 12.9 0.0 1.3 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain UCH PF00443.29 KOS22495.1 - 2.5e-52 178.0 0.0 5.1e-52 176.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS22495.1 - 2.2e-25 89.9 0.6 1.4e-19 70.9 0.0 2.4 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Peptidase_C98 PF15499.6 KOS22495.1 - 0.02 14.4 3.8 0.56 9.6 0.9 3.2 3 0 0 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase Glyco_transf_22 PF03901.17 KOS22496.1 - 1.4e-41 143.1 10.1 1.8e-41 142.7 10.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family SUIM_assoc PF16619.5 KOS22497.1 - 0.0082 16.2 4.2 0.0082 16.2 4.2 2.3 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 DUF3336 PF11815.8 KOS22498.1 - 3.4e-33 114.3 0.2 6.2e-33 113.4 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 KOS22498.1 - 3e-21 76.6 0.0 6.7e-21 75.4 0.0 1.6 1 0 0 1 1 1 1 Patatin-like phospholipase AMP-binding PF00501.28 KOS22499.1 - 6.6e-64 216.1 0.0 9.4e-64 215.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS22499.1 - 0.00039 21.3 0.2 0.0062 17.5 0.2 2.3 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain PIG-S PF10510.9 KOS22500.1 - 3.7e-166 554.0 0.1 4.2e-166 553.8 0.1 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein AhpC-TSA PF00578.21 KOS22501.1 - 8.6e-30 103.2 0.0 1.2e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 KOS22501.1 - 1.3e-12 47.4 0.1 2.3e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 KOS22501.1 - 2.7e-10 40.1 0.0 3.2e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Redoxin Kelch_6 PF13964.6 KOS22502.1 - 3.6e-05 23.9 0.5 3.1 8.2 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 KOS22502.1 - 4.1e-05 23.1 2.5 0.51 10.0 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 KOS22502.1 - 7.6e-05 22.6 0.3 0.036 14.1 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain BTB PF00651.31 KOS22502.1 - 0.0047 17.1 0.0 0.2 11.9 0.0 2.3 2 0 0 2 2 2 1 BTB/POZ domain Kelch_2 PF07646.15 KOS22502.1 - 0.014 15.4 0.1 5.3 7.2 0.0 3.0 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 KOS22502.1 - 0.11 12.5 0.2 13 5.9 0.2 3.0 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 KOS22502.1 - 0.2 12.0 9.1 1.9 8.9 0.0 4.4 5 0 0 5 5 5 0 Galactose oxidase, central domain AA_permease_2 PF13520.6 KOS22503.1 - 5.7e-44 150.6 25.1 3.2e-42 144.9 25.1 2.1 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS22503.1 - 1.2e-14 53.9 17.9 1.2e-14 53.9 17.9 2.2 2 1 0 2 2 2 1 Amino acid permease DUF3493 PF11998.8 KOS22503.1 - 0.17 12.1 2.5 6.2 7.1 0.0 3.5 3 1 0 3 3 3 0 Low psii accumulation1 / Rep27 DUF2628 PF10947.8 KOS22503.1 - 7.9 6.9 15.5 5.4 7.4 0.2 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2628) Myb_DNA-bind_6 PF13921.6 KOS22504.1 - 0.015 15.6 1.4 0.12 12.6 0.3 2.2 1 1 1 2 2 2 0 Myb-like DNA-binding domain CBM65_1 PF18259.1 KOS22504.1 - 0.06 13.5 0.2 0.68 10.1 0.0 2.0 1 1 1 2 2 2 0 Carbohydrate binding module 65 domain 1 DUF3759 PF12585.8 KOS22504.1 - 0.1 12.7 1.0 0.74 9.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3759) Myb_DNA-binding PF00249.31 KOS22504.1 - 0.12 12.6 1.5 0.6 10.4 0.0 2.4 1 1 1 2 2 2 0 Myb-like DNA-binding domain Abhydrolase_6 PF12697.7 KOS22505.1 - 0.052 14.1 19.5 0.078 13.6 19.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family Aldedh PF00171.22 KOS22506.1 - 9.6e-176 584.8 0.3 1.1e-175 584.6 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KOS22506.1 - 0.00014 21.4 0.1 0.25 10.7 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1487) PI3Ka PF00613.20 KOS22507.1 - 6.6e-58 195.2 0.1 1.1e-57 194.5 0.1 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 KOS22507.1 - 1.1e-45 156.5 0.1 1.1e-42 146.6 0.1 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase SRP-alpha_N PF04086.13 KOS22508.1 - 9.8e-77 258.7 0.0 1.3e-76 258.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54 PF00448.22 KOS22508.1 - 3.6e-52 176.9 0.1 5.8e-52 176.2 0.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 KOS22508.1 - 1.4e-08 34.8 0.3 4e-08 33.4 0.1 1.8 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 KOS22508.1 - 2.7e-06 26.6 0.0 5.3e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_30 PF13604.6 KOS22508.1 - 0.00082 19.1 0.1 0.002 17.9 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 KOS22508.1 - 0.0024 18.3 0.4 0.0069 16.8 0.1 1.9 2 0 0 2 2 2 1 AAA domain CbiA PF01656.23 KOS22508.1 - 0.0078 16.3 0.6 2 8.5 0.1 2.8 3 0 0 3 3 3 1 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 KOS22508.1 - 0.027 14.6 0.1 0.11 12.6 0.1 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_24 PF13479.6 KOS22508.1 - 0.051 13.3 0.0 0.1 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 KOS22508.1 - 0.051 13.9 0.1 0.21 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 KOS22508.1 - 0.063 13.4 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 KOS22508.1 - 0.073 12.5 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 KOS22508.1 - 0.09 13.3 0.0 0.23 12.0 0.0 1.7 2 0 0 2 2 1 0 ABC transporter AAA_31 PF13614.6 KOS22508.1 - 0.16 11.9 0.1 1.3 8.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain APS_kinase PF01583.20 KOS22508.1 - 0.18 11.7 0.4 0.6 10.0 0.0 2.1 2 0 0 2 2 2 0 Adenylylsulphate kinase YIF1 PF03878.15 KOS22509.1 - 4.4e-101 337.4 1.2 5.1e-101 337.2 1.2 1.0 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 KOS22509.1 - 0.0017 18.1 8.3 0.0017 18.1 8.3 1.5 2 0 0 2 2 2 1 Yip1 domain Mid2 PF04478.12 KOS22511.1 - 0.00042 20.2 0.2 0.00069 19.5 0.2 1.3 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF4686 PF15742.5 KOS22513.1 - 0.0024 17.1 7.4 0.0024 17.1 7.4 5.0 1 1 2 4 4 4 2 Domain of unknown function (DUF4686) Tht1 PF04163.12 KOS22513.1 - 0.46 9.2 1.8 0.75 8.5 1.8 1.3 1 0 0 1 1 1 0 Tht1-like nuclear fusion protein DUF3040 PF11239.8 KOS22513.1 - 2.3 8.5 6.0 14 6.0 0.5 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3040) ApoO PF09769.9 KOS22513.1 - 3.5 7.6 5.9 3.1 7.7 1.1 3.3 2 1 0 2 2 2 0 Apolipoprotein O 2OG-FeII_Oxy_2 PF13532.6 KOS22514.1 - 5e-26 92.1 0.0 6.2e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily FTO_NTD PF12933.7 KOS22514.1 - 0.12 11.6 0.0 0.57 9.4 0.0 1.9 1 1 1 2 2 2 0 FTO catalytic domain Met_10 PF02475.16 KOS22515.1 - 4.7e-69 232.1 0.0 6.3e-69 231.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein DUF1752 PF08550.10 KOS22516.1 - 1.6e-12 47.0 2.9 3.5e-12 45.9 2.9 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) RNB PF00773.19 KOS22517.1 - 7.5e-48 163.5 0.0 2.4e-47 161.9 0.0 1.7 1 1 0 1 1 1 1 RNB domain Pept_tRNA_hydro PF01195.19 KOS22518.1 - 3.1e-18 66.3 0.0 3.6e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase BAR PF03114.18 KOS22519.1 - 6.7e-65 219.1 2.6 8.1e-65 218.8 2.6 1.1 1 0 0 1 1 1 1 BAR domain CP12 PF02672.15 KOS22519.1 - 0.097 13.4 0.0 0.39 11.5 0.0 2.0 2 0 0 2 2 2 0 CP12 domain ERp29 PF07749.12 KOS22520.1 - 0.12 13.3 0.0 0.25 12.3 0.0 1.6 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Plasmodium_Vir PF05795.11 KOS22521.1 - 0.27 10.6 1.1 0.33 10.3 1.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CEND1 PF15677.5 KOS22521.1 - 0.61 10.6 6.6 1.6 9.3 6.6 1.7 1 1 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 Dicty_REP PF05086.12 KOS22521.1 - 0.99 7.3 8.4 1.1 7.1 8.4 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Zn_clus PF00172.18 KOS22522.1 - 1.8e-10 40.8 10.4 2.9e-10 40.1 10.4 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 KOS22522.1 - 3.2e-07 29.7 2.1 6.9e-07 28.6 2.1 1.6 1 1 0 1 1 1 1 Fungal specific transcription factor domain HBM PF16591.5 KOS22522.1 - 0.084 12.3 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain Glyco_hydro_47 PF01532.20 KOS22523.1 - 3.7e-149 497.5 0.0 4.2e-149 497.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DCP1 PF06058.13 KOS22524.1 - 6.5e-33 113.1 0.0 8.8e-33 112.7 0.0 1.1 1 0 0 1 1 1 1 Dcp1-like decapping family Exo_endo_phos PF03372.23 KOS22525.1 - 7.4e-09 35.5 0.1 3e-08 33.5 0.0 2.0 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family DUF4232 PF14016.6 KOS22525.1 - 0.15 12.2 0.0 0.41 10.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) DPBB_1 PF03330.18 KOS22526.1 - 4.3e-06 26.9 0.1 5.4e-05 23.4 0.1 2.2 1 1 0 1 1 1 1 Lytic transglycolase Viral_helicase1 PF01443.18 KOS22526.1 - 0.18 11.6 0.1 0.23 11.2 0.1 1.1 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Sugar_tr PF00083.24 KOS22528.1 - 2.3e-82 277.3 28.1 2.7e-82 277.0 28.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS22528.1 - 4.8e-18 65.2 37.6 5e-14 52.0 31.2 2.5 1 1 2 3 3 3 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS22528.1 - 0.00058 18.8 4.5 0.00058 18.8 4.5 2.3 2 0 0 2 2 2 1 MFS_1 like family PUCC PF03209.15 KOS22528.1 - 1.1 8.2 15.6 0.016 14.2 7.6 1.8 2 0 0 2 2 2 0 PUCC protein Sugar_tr PF00083.24 KOS22529.1 - 1.3e-88 297.9 20.4 1.5e-88 297.6 20.4 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS22529.1 - 1.1e-16 60.8 40.4 4.2e-12 45.7 13.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Arrestin_C PF02752.22 KOS22530.1 - 2.8e-15 57.0 0.6 7e-15 55.7 0.0 1.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain zf-ZPR1 PF03367.13 KOS22531.1 - 3e-114 378.2 0.0 8.5e-58 194.7 0.0 2.1 2 0 0 2 2 2 2 ZPR1 zinc-finger domain zinc-ribbons_6 PF07191.12 KOS22531.1 - 1 9.4 5.3 1.9 8.6 0.5 2.5 2 1 0 2 2 2 0 zinc-ribbons Rpr2 PF04032.16 KOS22532.1 - 1.1e-16 60.8 2.2 2.1e-16 60.0 0.3 2.1 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain PPR_2 PF13041.6 KOS22533.1 - 7.8e-07 29.2 0.2 0.0069 16.6 0.0 3.5 3 0 0 3 3 3 2 PPR repeat family PPR PF01535.20 KOS22533.1 - 0.00077 19.5 1.7 0.66 10.3 0.0 4.5 4 0 0 4 4 4 1 PPR repeat PPR_1 PF12854.7 KOS22533.1 - 0.0042 16.8 1.4 0.094 12.4 0.0 3.0 2 1 1 3 3 3 1 PPR repeat PPR_3 PF13812.6 KOS22533.1 - 0.2 11.8 0.1 0.8 9.8 0.0 1.9 1 1 1 2 2 2 0 Pentatricopeptide repeat domain GDPD PF03009.17 KOS22534.1 - 1.3e-70 238.1 0.0 2e-70 237.5 0.0 1.3 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 KOS22534.1 - 7.3e-24 84.2 0.0 2.6e-15 56.7 0.0 4.5 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS22534.1 - 3.8e-22 78.3 1.7 1.6e-07 31.7 0.0 6.3 5 1 1 6 6 6 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS22534.1 - 2.4e-19 69.2 0.5 5.9e-08 32.8 0.0 5.3 5 1 0 5 5 5 2 Ankyrin repeats (many copies) Ank PF00023.30 KOS22534.1 - 7.9e-14 51.4 4.5 0.0019 18.6 0.0 6.0 7 0 0 7 7 7 3 Ankyrin repeat Ank_3 PF13606.6 KOS22534.1 - 7.8e-13 47.4 3.4 0.0012 19.1 0.0 7.3 8 0 0 8 8 8 2 Ankyrin repeat SPX PF03105.19 KOS22534.1 - 3.8e-05 23.8 10.9 4.6e-05 23.5 0.0 3.1 3 1 1 4 4 4 2 SPX domain Env-gp36 PF09590.10 KOS22534.1 - 0.033 12.6 0.0 0.05 12.0 0.0 1.1 1 0 0 1 1 1 0 Lentivirus surface glycoprotein zf-C2H2 PF00096.26 KOS22535.1 - 1.6e-19 69.2 32.8 2.9e-06 27.4 1.1 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 KOS22535.1 - 4.1e-19 68.1 20.6 2.7e-06 27.6 1.0 4.7 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 KOS22535.1 - 5.7e-08 33.0 29.3 0.017 15.9 0.7 4.9 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 KOS22535.1 - 0.00012 22.2 2.7 0.42 11.0 0.3 3.9 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 KOS22535.1 - 0.008 16.5 0.4 0.008 16.5 0.4 4.3 4 0 0 4 4 4 1 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 KOS22535.1 - 0.012 15.3 1.9 0.012 15.3 1.9 2.9 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-TRAF PF02176.18 KOS22535.1 - 0.039 14.7 2.6 0.039 14.7 2.6 3.2 1 1 2 3 3 3 0 TRAF-type zinc finger zf-C2H2_8 PF15909.5 KOS22535.1 - 0.04 14.2 13.8 0.12 12.6 8.3 3.0 2 1 2 4 4 4 0 C2H2-type zinc ribbon DUF3947 PF13135.6 KOS22535.1 - 8.9 6.6 13.2 1 9.6 6.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) Peptidase_M41 PF01434.18 KOS22536.1 - 3.6e-55 186.8 0.7 7.5e-55 185.7 0.7 1.6 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 KOS22536.1 - 3.5e-42 144.0 0.0 7.8e-42 142.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 KOS22536.1 - 4.7e-08 32.7 0.1 9.3e-08 31.8 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KOS22536.1 - 3.5e-06 27.1 0.0 1e-05 25.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOS22536.1 - 1.2e-05 25.8 0.4 0.00012 22.5 0.4 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOS22536.1 - 7.9e-05 22.9 0.8 0.053 13.8 0.0 3.0 4 0 0 4 4 2 1 AAA domain TIP49 PF06068.13 KOS22536.1 - 8.3e-05 21.9 0.0 0.00016 21.0 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 KOS22536.1 - 0.00033 20.4 0.0 0.0009 19.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 KOS22536.1 - 0.002 18.3 0.0 0.006 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 KOS22536.1 - 0.0075 16.0 0.0 0.02 14.6 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_7 PF12775.7 KOS22536.1 - 0.012 15.1 0.0 0.048 13.2 0.0 2.0 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 KOS22536.1 - 0.016 14.8 0.7 1.3 8.6 0.2 2.7 2 1 0 3 3 3 0 AAA domain AAA_14 PF13173.6 KOS22536.1 - 0.032 14.3 0.0 0.3 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 KOS22536.1 - 0.037 13.4 0.2 0.037 13.4 0.2 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SpoU_sub_bind PF08032.12 KOS22536.1 - 0.045 14.0 0.1 11 6.4 0.0 2.9 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding TsaE PF02367.17 KOS22536.1 - 0.055 13.5 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_2 PF07724.14 KOS22536.1 - 0.084 13.0 0.0 0.32 11.1 0.0 2.0 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_24 PF13479.6 KOS22536.1 - 0.087 12.5 0.1 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 KOS22536.1 - 0.088 13.0 0.0 0.22 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 KOS22536.1 - 0.12 12.9 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS22536.1 - 0.33 10.9 2.7 1.5 8.7 0.1 2.5 3 0 0 3 3 2 0 NACHT domain Zeta_toxin PF06414.12 KOS22536.1 - 1.1 8.6 3.5 0.71 9.1 0.4 2.3 2 1 1 3 3 3 0 Zeta toxin Epimerase PF01370.21 KOS22537.1 - 1.5e-16 60.6 0.0 2.2e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 KOS22537.1 - 4.1e-11 42.4 0.0 5.3e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 KOS22537.1 - 5e-09 35.7 0.0 1.2e-08 34.5 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein NAD_binding_10 PF13460.6 KOS22537.1 - 7.2e-09 35.8 0.3 1.1e-08 35.2 0.3 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 KOS22537.1 - 5.6e-06 26.0 0.0 1e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 KOS22537.1 - 0.00027 20.6 0.2 0.00042 20.0 0.2 1.3 1 0 0 1 1 1 1 NmrA-like family adh_short PF00106.25 KOS22537.1 - 0.00087 18.8 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS22537.1 - 0.0032 17.4 0.1 0.005 16.8 0.1 1.3 1 0 0 1 1 1 1 KR domain F420_oxidored PF03807.17 KOS22537.1 - 0.0046 17.5 0.0 0.012 16.1 0.0 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Glyco_transf_4 PF13439.6 KOS22537.1 - 0.007 16.4 0.1 0.014 15.4 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 RmlD_sub_bind PF04321.17 KOS22537.1 - 0.048 12.7 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain adh_short_C2 PF13561.6 KOS22538.1 - 5e-59 199.7 3.0 5.9e-59 199.5 3.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS22538.1 - 9e-51 172.1 1.9 1.1e-50 171.8 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS22538.1 - 4.1e-09 36.6 3.0 2.2e-08 34.2 3.0 1.9 1 1 0 1 1 1 1 KR domain DNA_pol_lambd_f PF10391.9 KOS22538.1 - 0.1 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda DUF2399 PF09664.10 KOS22538.1 - 0.15 12.0 0.0 0.24 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) ORC6 PF05460.13 KOS22539.1 - 3.6e-31 108.7 3.5 1.2e-29 103.8 0.2 2.0 2 0 0 2 2 2 2 Origin recognition complex subunit 6 (ORC6) UPF0020 PF01170.18 KOS22540.1 - 3.5e-08 33.4 0.0 5.4e-06 26.2 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 N6-adenineMlase PF10237.9 KOS22540.1 - 0.18 11.6 0.0 2.5 7.9 0.0 2.1 2 0 0 2 2 2 0 Probable N6-adenine methyltransferase Mago_nashi PF02792.14 KOS22541.1 - 1.8e-72 242.0 0.1 2.1e-72 241.9 0.1 1.0 1 0 0 1 1 1 1 Mago nashi protein CRS1_YhbY PF01985.21 KOS22541.1 - 0.058 13.6 0.2 0.087 13.0 0.2 1.2 1 0 0 1 1 1 0 CRS1 / YhbY (CRM) domain Ish1 PF10281.9 KOS22542.1 - 1.3e-79 262.2 8.6 1.3e-15 57.4 0.0 8.2 8 0 0 8 8 8 7 Putative stress-responsive nuclear envelope protein SAP PF02037.27 KOS22542.1 - 3.3e-11 42.7 0.0 0.7 9.7 0.0 6.5 7 0 0 7 7 7 4 SAP domain Slx4 PF09494.10 KOS22542.1 - 5.4e-05 23.1 0.2 24 5.0 0.0 5.4 5 0 0 5 5 5 0 Slx4 endonuclease HeH PF12949.7 KOS22542.1 - 0.0032 17.1 0.1 42 4.0 0.0 5.0 6 0 0 6 6 6 0 HeH/LEM domain Recombinase PF07508.13 KOS22542.1 - 0.051 14.0 0.2 0.43 11.0 0.0 2.6 3 0 0 3 3 3 0 Recombinase DUF905 PF06006.12 KOS22542.1 - 0.073 13.1 0.0 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF905) SAM_2 PF07647.17 KOS22542.1 - 0.39 10.9 2.7 1.5 9.0 0.1 3.3 5 0 0 5 5 5 0 SAM domain (Sterile alpha motif) Lipase3_N PF03893.16 KOS22542.1 - 0.96 9.5 3.8 6 7.0 0.4 3.3 3 1 0 3 3 3 0 Lipase 3 N-terminal region AAA PF00004.29 KOS22543.1 - 1.4e-39 135.5 0.0 2.9e-39 134.5 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 KOS22543.1 - 1.5e-17 63.3 0.2 3.1e-17 62.3 0.2 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 KOS22543.1 - 3e-08 33.3 0.0 6.8e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 KOS22543.1 - 0.00018 21.5 1.2 0.001 19.1 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 KOS22543.1 - 0.00031 21.2 1.6 0.051 14.0 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 KOS22543.1 - 0.00046 20.0 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 KOS22543.1 - 0.0041 17.4 1.6 0.24 11.7 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_2 PF07724.14 KOS22543.1 - 0.0093 16.1 0.0 0.0093 16.1 0.0 2.6 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 KOS22543.1 - 0.01 15.3 0.2 0.13 11.7 0.1 2.2 2 0 0 2 2 2 0 PhoH-like protein Mg_chelatase PF01078.21 KOS22543.1 - 0.012 15.0 0.1 0.038 13.4 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 KOS22543.1 - 0.023 13.8 0.0 0.053 12.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_11 PF13086.6 KOS22543.1 - 0.042 13.6 1.9 0.37 10.5 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 KOS22543.1 - 0.048 13.8 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 KOS22543.1 - 0.071 12.4 0.0 0.18 11.1 0.0 1.7 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 KOS22543.1 - 0.11 11.9 0.0 0.31 10.6 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region tRNA-synt_1c PF00749.21 KOS22544.1 - 2.7e-98 328.7 0.0 3.8e-98 328.2 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 KOS22544.1 - 9.5e-28 97.2 0.0 3e-27 95.6 0.0 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain NHase_beta PF02211.15 KOS22544.1 - 0.12 12.4 0.3 0.23 11.4 0.3 1.4 1 0 0 1 1 1 0 Nitrile hydratase beta subunit Hc1 PF07432.13 KOS22544.1 - 0.66 10.4 9.6 1.3 9.4 9.6 1.4 1 0 0 1 1 1 0 Histone H1-like protein Hc1 BOP1NT PF08145.12 KOS22545.1 - 3.3e-104 348.4 5.2 5.7e-104 347.6 5.2 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 KOS22545.1 - 9.6e-27 92.7 5.1 9.9e-13 48.4 0.4 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22545.1 - 1.8e-05 24.9 0.1 0.032 14.5 0.0 4.4 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS22545.1 - 0.013 14.5 0.0 0.022 13.7 0.0 1.3 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 KOS22545.1 - 0.021 13.2 0.0 0.14 10.4 0.0 2.1 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Nop14 PF04147.12 KOS22545.1 - 2.6 6.2 26.7 3.7 5.6 26.7 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_lig_T4_1 PF09511.10 KOS22546.1 - 3e-84 282.3 0.0 5.5e-84 281.4 0.0 1.4 1 0 0 1 1 1 1 RNA ligase tRNA_lig_CPD PF08302.11 KOS22546.1 - 1.2e-78 264.1 0.0 1.6e-78 263.7 0.0 1.2 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain tRNA_lig_kinase PF08303.11 KOS22546.1 - 3.9e-32 111.7 0.0 1.4e-25 90.4 0.0 2.7 2 1 1 3 3 3 2 tRNA ligase kinase domain Ank_5 PF13857.6 KOS22547.1 - 1.5e-08 34.7 0.0 2.8e-06 27.5 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 KOS22547.1 - 2e-08 34.6 0.0 6.2e-05 23.5 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS22547.1 - 4.9e-06 26.5 0.2 0.0037 17.7 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 KOS22547.1 - 2.5e-05 24.8 0.1 4.2e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) GCV_T PF01571.21 KOS22547.1 - 0.0046 16.4 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain Ribosomal_L10 PF00466.20 KOS22548.1 - 0.016 15.3 0.1 0.46 10.6 0.0 2.3 2 1 0 2 2 2 0 Ribosomal protein L10 Keratin_2_head PF16208.5 KOS22549.1 - 0.016 15.3 7.8 0.02 15.0 7.8 1.1 1 0 0 1 1 1 0 Keratin type II head TNRC6-PABC_bdg PF16608.5 KOS22549.1 - 0.23 11.2 3.1 0.25 11.0 3.1 1.3 1 0 0 1 1 1 0 TNRC6-PABC binding domain ARS2 PF04959.13 KOS22549.1 - 0.8 10.0 2.4 0.98 9.8 2.4 1.1 1 0 0 1 1 1 0 Arsenite-resistance protein 2 RabGAP-TBC PF00566.18 KOS22550.1 - 2.1e-46 158.3 0.0 3.2e-46 157.7 0.0 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain EF-hand_6 PF13405.6 KOS22550.1 - 0.001 18.8 0.3 0.16 12.0 0.4 3.2 2 0 0 2 2 2 1 EF-hand domain GRAM PF02893.20 KOS22550.1 - 0.023 14.6 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 GRAM domain KCT2 PF17818.1 KOS22550.1 - 0.03 14.4 0.9 0.085 13.0 0.9 1.7 1 0 0 1 1 1 0 Keratinocyte-associated gene product Pal1 PF08316.11 KOS22551.1 - 5.8e-48 163.2 1.2 1e-47 162.3 1.2 1.4 1 0 0 1 1 1 1 Pal1 cell morphology protein Exo_endo_phos PF03372.23 KOS22552.1 - 1.6e-05 24.5 0.0 4.8e-05 23.0 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Pkinase PF00069.25 KOS22553.1 - 4.2e-65 219.7 0.0 5.4e-65 219.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22553.1 - 5.9e-31 107.7 0.0 7.4e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS22553.1 - 9.4e-06 25.1 0.0 1.2e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS22553.1 - 0.00011 22.2 0.1 0.0049 16.8 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 KOS22553.1 - 0.0044 16.1 0.0 0.0067 15.5 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 KOS22553.1 - 0.057 12.2 0.0 0.082 11.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 KOS22553.1 - 0.059 12.3 0.0 0.074 12.0 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain HrcA_DNA-bdg PF03444.15 KOS22554.1 - 8.7 6.1 6.9 0.76 9.5 1.3 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding Pkinase PF00069.25 KOS22555.1 - 2.4e-26 92.7 0.0 3.1e-26 92.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22555.1 - 6.8e-14 51.8 0.0 9.4e-14 51.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS22555.1 - 4.1e-09 35.7 0.0 6.4e-09 35.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 KOS22555.1 - 0.00015 21.8 0.3 0.0014 18.6 0.0 2.4 2 1 0 3 3 3 1 Phosphotransferase enzyme family ATP-synt_C PF00137.21 KOS22559.1 - 2.1e-28 98.4 34.9 1.8e-17 63.4 13.0 2.1 2 0 0 2 2 2 2 ATP synthase subunit C BTB PF00651.31 KOS22561.1 - 1.8e-08 34.5 0.0 3.2e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 BTB/POZ domain CDC45 PF02724.14 KOS22561.1 - 0.14 10.5 0.0 0.19 10.0 0.0 1.2 1 0 0 1 1 1 0 CDC45-like protein UBD PF16455.5 KOS22562.1 - 3.2e-36 123.7 0.0 4.5e-36 123.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-binding domain Sigma70_ner PF04546.13 KOS22562.1 - 0.53 10.1 3.6 0.67 9.8 3.6 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 KOS22562.1 - 1.1 7.4 4.6 1.3 7.2 4.6 1.1 1 0 0 1 1 1 0 Nop14-like family Pre-SET PF05033.16 KOS22565.1 - 5.1e-18 65.7 2.2 1.7e-17 64.0 0.5 2.2 2 0 0 2 2 2 1 Pre-SET motif SET PF00856.28 KOS22565.1 - 7.6e-18 65.5 0.0 5.7e-17 62.6 0.0 2.1 1 1 0 1 1 1 1 SET domain AWS PF17907.1 KOS22565.1 - 0.027 14.5 1.0 0.027 14.5 1.0 2.5 3 0 0 3 3 3 0 AWS domain LUC7 PF03194.15 KOS22567.1 - 5.5e-72 242.5 2.1 6.4e-72 242.2 2.1 1.0 1 0 0 1 1 1 1 LUC7 N_terminus MCPsignal PF00015.21 KOS22567.1 - 0.0032 17.3 0.3 0.0085 15.9 0.2 1.7 1 1 1 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1241 PF06840.11 KOS22567.1 - 0.0062 16.2 0.1 0.01 15.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1241) LMBR1 PF04791.16 KOS22567.1 - 0.015 14.3 1.1 0.021 13.8 1.1 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF2130 PF09903.9 KOS22567.1 - 0.015 14.6 0.9 0.027 13.8 0.9 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF948 PF06103.11 KOS22567.1 - 0.048 13.9 0.1 0.094 13.0 0.1 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) KxDL PF10241.9 KOS22567.1 - 0.054 13.8 0.2 0.15 12.4 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein PIN_8 PF18476.1 KOS22567.1 - 0.079 12.8 0.4 0.13 12.1 0.2 1.4 1 1 0 1 1 1 0 PIN like domain Spc7 PF08317.11 KOS22567.1 - 0.097 11.5 1.5 0.11 11.4 0.7 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein RPT PF13446.6 KOS22567.1 - 0.13 12.2 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 A repeated domain in UCH-protein AIG1 PF04548.16 KOS22567.1 - 0.14 11.5 0.1 0.21 10.9 0.1 1.3 1 0 0 1 1 1 0 AIG1 family gpW PF02831.15 KOS22567.1 - 0.17 11.8 0.5 0.52 10.3 0.1 2.0 2 0 0 2 2 2 0 gpW ARGLU PF15346.6 KOS22567.1 - 0.66 9.9 5.3 1.5 8.7 5.0 1.7 1 1 0 1 1 1 0 Arginine and glutamate-rich 1 SANT_DAMP1_like PF16282.5 KOS22568.1 - 0.014 15.6 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 SANT/Myb-like domain of DAMP1 Myb_DNA-binding PF00249.31 KOS22568.1 - 0.026 14.7 0.2 0.054 13.7 0.2 1.6 1 1 0 1 1 1 0 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 KOS22568.1 - 0.038 13.9 0.8 0.053 13.4 0.8 1.3 1 0 0 1 1 1 0 Myb DNA-binding like Nuc_deoxyri_tr2 PF15891.5 KOS22569.1 - 7.5e-38 129.2 0.0 9.8e-38 128.8 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase like Nuc_deoxyrib_tr PF05014.15 KOS22569.1 - 0.0035 17.4 0.0 0.0048 16.9 0.0 1.2 1 0 0 1 1 1 1 Nucleoside 2-deoxyribosyltransferase Tetraspanin PF00335.20 KOS22572.1 - 0.003 17.3 0.0 0.0076 16.0 0.0 1.8 1 1 0 1 1 1 1 Tetraspanin family NADHdeh_related PF10125.9 KOS22572.1 - 0.31 10.4 2.0 0.47 9.8 2.0 1.3 1 0 0 1 1 1 0 NADH dehydrogenase I, subunit N related protein Aldedh PF00171.22 KOS22573.1 - 1.8e-184 613.6 0.1 2e-184 613.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 KOS22573.1 - 0.068 12.6 0.1 1.3 8.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) PIGA PF08288.12 KOS22574.1 - 2.1e-46 156.4 2.6 3.2e-46 155.8 0.7 2.2 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glycos_transf_1 PF00534.20 KOS22574.1 - 2.8e-27 95.4 0.0 4.3e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 KOS22574.1 - 3.1e-26 92.4 0.4 5.3e-26 91.6 0.4 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 KOS22574.1 - 5.1e-23 82.0 0.0 1.1e-22 80.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 KOS22574.1 - 5.4e-11 43.2 0.0 8.7e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 KOS22574.1 - 7.2e-05 22.8 0.1 0.00013 22.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 KOS22574.1 - 0.0047 17.3 0.0 0.022 15.2 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferases group 1 SSP160 PF06933.11 KOS22574.1 - 0.031 12.5 8.1 0.042 12.1 8.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 KOS22574.1 - 0.1 10.7 2.1 0.13 10.3 2.1 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Sporozoite_P67 PF05642.11 KOS22574.1 - 1.7 6.6 5.4 2.3 6.2 5.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.12 KOS22574.1 - 1.9 6.4 3.8 1.1 7.2 2.1 1.3 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 KOS22574.1 - 3.4 7.7 19.7 6.2 6.8 19.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DEAD PF00270.29 KOS22575.1 - 7e-32 110.6 0.0 8.8e-15 54.9 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 KOS22575.1 - 5.9e-21 74.9 0.0 3.4e-20 72.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 KOS22575.1 - 5.5e-08 33.0 0.0 5.5e-08 33.0 0.0 3.0 2 2 0 2 2 2 1 Type III restriction enzyme, res subunit AF-4 PF05110.13 KOS22575.1 - 0.0013 16.9 18.1 0.0013 16.9 18.1 2.2 2 0 0 2 2 2 1 AF-4 proto-oncoprotein PS-DH PF14765.6 KOS22576.1 - 1.6e-62 211.4 0.0 2.4e-62 210.9 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 KOS22576.1 - 5.7e-62 210.1 0.0 9.9e-62 209.3 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain ketoacyl-synt PF00109.26 KOS22576.1 - 1.1e-58 198.8 1.0 3.9e-57 193.7 0.0 3.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 KOS22576.1 - 2.1e-58 197.2 0.2 5.8e-58 195.7 0.2 1.8 1 0 0 1 1 1 1 KR domain Ketoacyl-synt_C PF02801.22 KOS22576.1 - 9.1e-32 109.6 0.3 2e-31 108.4 0.3 1.6 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KAsynt_C_assoc PF16197.5 KOS22576.1 - 2.9e-24 85.7 0.0 6e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension Methyltransf_12 PF08242.12 KOS22576.1 - 3.7e-20 72.5 0.0 8.3e-20 71.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N_2 PF13602.6 KOS22576.1 - 9.7e-17 62.3 0.0 4.7e-15 56.8 0.0 2.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOS22576.1 - 7.7e-16 58.3 0.0 2.3e-15 56.7 0.0 1.8 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Methyltransf_31 PF13847.6 KOS22576.1 - 4.8e-11 42.7 0.0 1.4e-10 41.2 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22576.1 - 7.1e-11 42.7 0.0 2.7e-10 40.8 0.0 2.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS22576.1 - 8e-10 38.8 0.0 2.1e-09 37.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain adh_short PF00106.25 KOS22576.1 - 2.2e-09 37.0 0.6 6.8e-09 35.5 0.1 2.1 2 0 0 2 2 2 1 short chain dehydrogenase Methyltransf_11 PF08241.12 KOS22576.1 - 5.4e-08 33.4 0.0 1.5e-07 31.9 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain ADH_N PF08240.12 KOS22576.1 - 1.1e-05 25.3 0.5 2.9e-05 23.9 0.5 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain adh_short_C2 PF13561.6 KOS22576.1 - 2.8e-05 23.8 0.0 7.7e-05 22.4 0.0 1.7 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase PP-binding PF00550.25 KOS22576.1 - 0.00049 20.4 0.1 0.0018 18.6 0.1 2.0 1 0 0 1 1 1 1 Phosphopantetheine attachment site Ubie_methyltran PF01209.18 KOS22576.1 - 0.00068 19.0 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Thiolase_N PF00108.23 KOS22576.1 - 0.0047 16.3 0.2 0.016 14.6 0.1 1.8 2 0 0 2 2 2 1 Thiolase, N-terminal domain Methyltransf_28 PF02636.17 KOS22576.1 - 0.074 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase NAD_binding_10 PF13460.6 KOS22576.1 - 0.11 12.4 0.0 0.32 10.9 0.0 1.8 1 0 0 1 1 1 0 NAD(P)H-binding Methyltransf_16 PF10294.9 KOS22576.1 - 0.15 11.8 0.1 0.79 9.4 0.0 2.1 2 1 0 2 2 2 0 Lysine methyltransferase Thioesterase PF00975.20 KOS22577.1 - 1.7e-10 41.4 0.0 1.9e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Engrail_1_C_sig PF10525.9 KOS22578.1 - 0.4 10.0 1.5 1.1 8.5 1.5 1.7 1 0 0 1 1 1 0 Engrailed homeobox C-terminal signature domain Lyase_1 PF00206.20 KOS22579.1 - 2.3e-24 86.3 0.1 4.7e-24 85.4 0.0 1.5 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.9 KOS22579.1 - 5.3e-15 55.7 0.2 6.1e-14 52.3 0.0 2.6 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus Ribosomal_L26 PF16906.5 KOS22580.1 - 5.1e-37 126.2 2.6 6.7e-37 125.8 2.6 1.1 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 KOS22580.1 - 1.1e-07 31.5 1.6 3.1e-07 30.1 1.6 1.7 1 0 0 1 1 1 1 KOW motif DUF1223 PF06764.11 KOS22580.1 - 0.003 17.6 0.3 0.003 17.6 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1223) GHL5 PF14872.6 KOS22580.1 - 0.022 12.8 0.0 0.025 12.6 0.0 1.0 1 0 0 1 1 1 0 Hypothetical glycoside hydrolase 5 Rad51 PF08423.11 KOS22581.1 - 7e-44 150.0 0.0 3.4e-43 147.7 0.0 1.8 1 1 0 1 1 1 1 Rad51 RecA PF00154.21 KOS22581.1 - 1.4e-09 37.8 0.8 1.3e-07 31.4 0.8 2.1 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 KOS22581.1 - 3e-07 30.2 0.2 6.1e-07 29.2 0.2 1.5 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 KOS22581.1 - 0.0001 21.7 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_24 PF13479.6 KOS22581.1 - 0.048 13.4 0.0 0.084 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOS22581.1 - 0.1 13.1 0.1 0.2 12.2 0.1 1.4 1 0 0 1 1 1 0 ABC transporter Pox_A32 PF04665.12 KOS22581.1 - 0.29 10.6 0.0 0.45 9.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus A32 protein DUF1180 PF06679.12 KOS22581.1 - 7.4 7.0 7.4 14 6.1 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) RNA_pol_Rpb2_6 PF00562.28 KOS22582.1 - 2.2e-121 405.6 0.1 3.8e-121 404.8 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 KOS22582.1 - 6.2e-55 185.9 0.1 1.1e-54 185.0 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 KOS22582.1 - 1.3e-32 112.1 0.5 2.9e-32 110.9 0.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_2 PF04561.14 KOS22582.1 - 1.6e-28 99.6 0.1 4.8e-28 98.1 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 KOS22582.1 - 5.8e-21 74.5 0.3 1.7e-20 73.1 0.3 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 KOS22582.1 - 1.8e-20 72.9 0.0 3.5e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 KOS22582.1 - 1.7e-10 41.3 0.9 6.2e-10 39.5 0.9 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 Ribosomal_L15e PF00827.17 KOS22583.1 - 3.7e-81 271.4 7.6 5.6e-81 270.8 7.6 1.2 1 0 0 1 1 1 1 Ribosomal L15 SipA_VBS PF17985.1 KOS22584.1 - 0.037 13.9 0.0 19 5.4 0.0 2.8 2 0 0 2 2 2 0 SipA vinculin binding site PUCC PF03209.15 KOS22584.1 - 0.25 10.3 0.1 0.34 9.9 0.1 1.1 1 0 0 1 1 1 0 PUCC protein RasGEF PF00617.19 KOS22585.1 - 8.2e-47 159.7 0.0 5.9e-46 156.9 0.0 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 KOS22585.1 - 3.8e-10 39.9 0.5 7.2e-10 39.0 0.1 1.7 2 0 0 2 2 2 1 RasGEF N-terminal motif RsgA_GTPase PF03193.16 KOS22585.1 - 0.0046 16.9 0.0 4.3 7.2 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ABC_tran PF00005.27 KOS22585.1 - 0.026 15.0 0.0 0.08 13.5 0.0 1.8 1 0 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 KOS22585.1 - 0.028 14.5 0.0 0.06 13.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 KOS22585.1 - 0.037 14.3 0.0 1.2 9.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain Ras PF00071.22 KOS22585.1 - 0.042 13.4 0.0 0.39 10.3 0.0 2.4 2 1 0 2 2 2 0 Ras family AAA_29 PF13555.6 KOS22585.1 - 0.06 13.1 0.1 0.52 10.1 0.0 2.6 3 0 0 3 3 3 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 KOS22585.1 - 0.16 12.0 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 Dynamin family Nfu_N PF08712.11 KOS22588.1 - 1e-27 96.0 0.0 2.1e-27 95.0 0.0 1.6 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal NifU PF01106.17 KOS22588.1 - 2.8e-27 94.7 0.1 4.4e-27 94.0 0.1 1.3 1 0 0 1 1 1 1 NifU-like domain Carn_acyltransf PF00755.20 KOS22589.1 - 7.4e-208 691.9 0.0 1e-207 691.4 0.0 1.2 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase DUF2315 PF10231.9 KOS22589.1 - 0.14 12.3 0.1 1.7 8.8 0.1 2.2 2 0 0 2 2 2 0 Apoptogenic protein 1 NTPase_I-T PF01931.18 KOS22590.1 - 2.5e-05 24.1 0.0 3.5e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF84 RRM_1 PF00076.22 KOS22591.1 - 1.1e-07 31.5 0.0 1.8e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Serglycin PF04360.12 KOS22591.1 - 0.15 12.0 9.7 0.28 11.1 9.7 1.4 1 0 0 1 1 1 0 Serglycin Citrate_synt PF00285.21 KOS22592.1 - 4.7e-100 335.1 0.0 6e-100 334.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Eclosion PF04736.12 KOS22592.1 - 0.025 14.3 0.0 0.057 13.1 0.0 1.5 1 0 0 1 1 1 0 Eclosion hormone Nic96 PF04097.14 KOS22593.1 - 9e-219 728.0 0.0 1.2e-218 727.6 0.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 Nucleoporin_FG PF13634.6 KOS22593.1 - 1.1e-06 29.4 83.5 6.2e-05 23.8 45.8 4.9 2 1 2 4 4 4 2 Nucleoporin FG repeat region DUF3425 PF11905.8 KOS22594.1 - 2.3e-17 63.1 0.4 5.3e-17 62.0 0.4 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3425) bZIP_1 PF00170.21 KOS22594.1 - 0.0028 17.7 6.2 0.0028 17.7 6.2 1.9 2 0 0 2 2 2 1 bZIP transcription factor E1-E2_ATPase PF00122.20 KOS22596.1 - 7e-48 162.5 4.5 7e-48 162.5 4.5 3.0 4 0 0 4 4 4 1 E1-E2 ATPase Hydrolase PF00702.26 KOS22596.1 - 9.1e-17 62.0 0.0 2.5e-16 60.6 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOS22596.1 - 5e-10 38.9 0.0 1.1e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS22596.1 - 0.0025 17.6 0.1 0.0046 16.7 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS22596.1 - 0.065 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Apc15p PF05841.11 KOS22597.1 - 1.2e-21 77.8 4.7 1.2e-21 77.8 4.7 2.0 2 1 0 2 2 2 1 Apc15p protein GATase_2 PF00310.21 KOS22598.1 - 2.8e-183 609.4 0.0 4.5e-183 608.7 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 KOS22598.1 - 1.1e-155 518.3 0.0 3.4e-155 516.7 0.0 1.8 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 KOS22598.1 - 2.1e-109 365.3 0.0 2.1e-107 358.7 0.0 2.2 2 0 0 2 2 2 1 Glutamate synthase central domain GXGXG PF01493.19 KOS22598.1 - 3.2e-86 287.8 1.5 5.4e-86 287.0 1.5 1.4 1 0 0 1 1 1 1 GXGXG motif Pyr_redox_2 PF07992.14 KOS22598.1 - 7.7e-23 81.1 0.1 7.1e-22 78.0 0.1 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Fer4_20 PF14691.6 KOS22598.1 - 2.6e-21 75.5 0.1 5.1e-21 74.6 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster NAD_binding_8 PF13450.6 KOS22598.1 - 2.6e-09 37.2 0.0 1e-08 35.3 0.0 2.1 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOS22598.1 - 5.9e-08 33.2 0.1 9.2e-05 22.9 0.1 3.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOS22598.1 - 6.5e-07 29.0 0.1 2.2e-06 27.3 0.1 1.9 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 KOS22598.1 - 1.7e-06 27.5 0.7 0.012 14.9 0.0 3.6 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS22598.1 - 1.8e-06 27.8 3.2 0.00064 19.4 0.2 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.14 KOS22598.1 - 1.9e-05 23.6 0.1 1.9e-05 23.6 0.1 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_oxidored PF12831.7 KOS22598.1 - 4.8e-05 22.9 0.2 9e-05 22.0 0.2 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS22598.1 - 7.8e-05 21.9 0.1 0.00027 20.2 0.1 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_7 PF13241.6 KOS22598.1 - 0.00022 21.6 0.0 1.9 9.0 0.1 3.3 3 0 0 3 3 3 2 Putative NAD(P)-binding FAD_binding_3 PF01494.19 KOS22598.1 - 0.00096 18.5 0.0 0.0022 17.3 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain FMO-like PF00743.19 KOS22598.1 - 0.0017 16.8 0.2 0.42 9.0 0.0 2.8 3 0 0 3 3 3 1 Flavin-binding monooxygenase-like Lycopene_cycl PF05834.12 KOS22598.1 - 0.0059 15.7 0.2 0.22 10.5 0.1 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein AlaDh_PNT_C PF01262.21 KOS22598.1 - 0.007 15.7 0.1 1.3 8.3 0.0 2.4 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Thi4 PF01946.17 KOS22598.1 - 0.01 15.1 0.2 0.035 13.3 0.2 1.9 1 0 0 1 1 1 0 Thi4 family AdoHcyase_NAD PF00670.21 KOS22598.1 - 0.022 14.8 0.2 8.4 6.4 0.0 2.8 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMN_dh PF01070.18 KOS22598.1 - 0.029 13.4 0.8 0.13 11.2 0.8 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NAD_Gly3P_dh_N PF01210.23 KOS22598.1 - 0.03 14.3 0.0 0.073 13.0 0.0 1.7 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GIDA PF01134.22 KOS22598.1 - 0.073 12.1 1.2 0.18 10.8 0.0 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A F420_oxidored PF03807.17 KOS22598.1 - 0.097 13.3 0.0 1.5 9.4 0.1 2.8 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 KOS22598.1 - 0.14 12.2 0.1 12 5.9 0.0 2.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 KOS22598.1 - 0.26 11.1 1.5 1.8 8.4 0.0 2.6 2 0 0 2 2 2 0 Rossmann-like domain VTC PF09359.10 KOS22599.1 - 9.7e-88 294.1 0.8 1.6e-87 293.4 0.8 1.3 1 0 0 1 1 1 1 VTC domain DUF202 PF02656.15 KOS22599.1 - 1.4e-11 44.7 1.6 3.7e-11 43.3 1.6 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF202) SPX PF03105.19 KOS22599.1 - 9.1e-07 29.1 22.0 5.3e-05 23.3 0.1 4.0 3 1 2 5 5 5 2 SPX domain TAF4 PF05236.14 KOS22599.1 - 0.0024 17.7 0.0 0.0048 16.7 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family MgtE PF01769.16 KOS22599.1 - 0.044 14.2 0.2 0.075 13.4 0.2 1.3 1 0 0 1 1 1 0 Divalent cation transporter T3SSipB PF16535.5 KOS22599.1 - 0.16 12.4 0.2 0.16 12.4 0.2 2.6 2 1 0 2 2 2 0 Type III cell invasion protein SipB AAA_23 PF13476.6 KOS22599.1 - 0.5 10.8 3.8 0.24 11.9 0.2 2.0 2 0 0 2 2 2 0 AAA domain K_channel_TID PF07941.11 KOS22599.1 - 1.1 9.8 11.4 3.8 8.0 11.4 2.0 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain FGGY_C PF02782.16 KOS22600.1 - 3.2e-47 160.8 1.0 5.2e-47 160.1 1.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 KOS22600.1 - 2.3e-25 89.6 0.1 1.3e-21 77.3 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 KOS22600.1 - 0.06 12.8 0.2 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family IBR PF01485.21 KOS22601.1 - 1.4e-22 79.6 19.8 2e-13 50.4 0.9 3.7 3 1 0 3 3 3 2 IBR domain, a half RING-finger domain zf-AN1 PF01428.16 KOS22601.1 - 0.015 15.5 2.6 0.015 15.5 2.6 3.8 3 2 0 3 3 3 0 AN1-like Zinc finger SDA1 PF05285.12 KOS22601.1 - 0.26 10.7 2.9 0.36 10.2 2.9 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 KOS22601.1 - 1.3 8.3 3.5 1.6 8.0 3.5 1.2 1 0 0 1 1 1 0 BUD22 zinc_ribbon_12 PF11331.8 KOS22601.1 - 3.9 7.4 10.0 2.2 8.2 0.1 3.4 3 1 0 3 3 3 0 Probable zinc-ribbon domain Nop14 PF04147.12 KOS22601.1 - 6 5.0 5.5 8.4 4.5 5.5 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 KOS22601.1 - 7.5 5.0 8.5 12 4.4 8.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) HSP70 PF00012.20 KOS22602.1 - 3.5e-08 32.1 0.7 5.3e-06 24.9 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein BcrAD_BadFG PF01869.20 KOS22602.1 - 0.046 13.2 0.5 0.072 12.6 0.0 1.5 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family FGGY_C PF02782.16 KOS22602.1 - 0.067 12.9 0.0 1 9.0 0.0 2.1 1 1 1 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Peptidase_M22 PF00814.25 KOS22602.1 - 0.073 12.8 0.0 0.15 11.7 0.0 1.5 2 0 0 2 2 2 0 Glycoprotease family DOCK_N PF16172.5 KOS22603.1 - 4.7e-122 407.5 0.0 7.8e-122 406.8 0.0 1.4 1 0 0 1 1 1 1 DOCK N-terminus DHR-2 PF06920.13 KOS22603.1 - 5.1e-32 111.2 3.0 2.5e-31 108.9 0.9 2.4 2 1 0 2 2 2 1 Dock homology region 2 DOCK-C2 PF14429.6 KOS22603.1 - 8.7e-26 90.9 0.0 1.6e-25 90.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins SH3_1 PF00018.28 KOS22603.1 - 9.1e-06 25.2 0.0 1.9e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS22603.1 - 0.0022 17.8 0.0 0.0098 15.7 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain Acetyltransf_1 PF00583.25 KOS22604.1 - 0.00079 19.7 0.0 0.0062 16.8 0.0 2.4 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_5 PF13444.6 KOS22604.1 - 0.0011 19.7 0.0 1.9 9.2 0.0 3.0 2 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22604.1 - 0.038 14.4 0.0 0.083 13.3 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 KOS22604.1 - 0.19 11.7 0.0 27 4.7 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain tRNA-synt_1 PF00133.22 KOS22606.1 - 1.6e-38 132.4 0.0 1.6e-27 96.0 0.0 3.2 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 KOS22606.1 - 1.5e-15 56.8 0.3 1.3e-09 37.3 0.0 3.1 3 0 0 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 KOS22606.1 - 9.5e-11 41.9 0.3 2.1e-10 40.8 0.3 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 KOS22606.1 - 9.1e-08 31.8 0.0 1.8e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain zf-CSL PF05207.13 KOS22607.1 - 2.2e-23 81.7 0.6 2.7e-23 81.4 0.6 1.1 1 0 0 1 1 1 1 CSL zinc finger Zn-ribbon_8 PF09723.10 KOS22607.1 - 0.00035 20.6 0.5 0.00053 20.1 0.5 1.3 1 0 0 1 1 1 1 Zinc ribbon domain zf-RING_4 PF14570.6 KOS22607.1 - 0.025 14.3 0.4 0.038 13.8 0.4 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Prok-RING_1 PF14446.6 KOS22607.1 - 0.36 10.8 3.7 0.74 9.8 3.7 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 ABC_membrane_2 PF06472.15 KOS22608.1 - 5.2e-102 340.9 1.6 8.7e-102 340.1 1.6 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KOS22608.1 - 1.6e-17 64.3 0.0 3.2e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOS22608.1 - 0.0024 17.7 0.0 0.0059 16.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOS22608.1 - 0.016 15.7 0.2 0.062 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 KOS22608.1 - 0.046 13.1 0.0 0.14 11.6 0.0 1.7 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Rad17 PF03215.15 KOS22608.1 - 0.056 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_29 PF13555.6 KOS22608.1 - 0.065 13.0 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RuvB_N PF05496.12 KOS22608.1 - 0.11 12.2 0.0 0.54 10.0 0.0 2.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_7 PF12775.7 KOS22608.1 - 0.14 11.7 0.0 0.29 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOS22608.1 - 0.2 11.0 0.1 0.59 9.5 0.1 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Frataxin_Cyay PF01491.16 KOS22609.1 - 2.8e-36 123.9 0.0 3.8e-36 123.4 0.0 1.1 1 0 0 1 1 1 1 Frataxin-like domain Clat_adaptor_s PF01217.20 KOS22610.1 - 2.1e-42 144.4 0.0 4.3e-42 143.4 0.0 1.5 1 1 0 1 1 1 1 Clathrin adaptor complex small chain COG5 PF10392.9 KOS22611.1 - 0.064 13.4 0.4 0.63 10.2 0.1 2.5 2 1 0 2 2 2 0 Golgi transport complex subunit 5 Sds3 PF08598.11 KOS22612.1 - 8.1e-21 75.0 14.9 1.8e-20 73.9 14.9 1.7 1 1 0 1 1 1 1 Sds3-like Glyco_hydro_31 PF01055.26 KOS22613.1 - 1.1e-108 364.3 0.5 1.4e-108 364.0 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 KOS22613.1 - 9.9e-15 54.6 0.0 2.4e-14 53.4 0.0 1.7 1 0 0 1 1 1 1 Galactose mutarotase-like DUF4015 PF13200.6 KOS22613.1 - 0.16 11.0 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 Putative glycosyl hydrolase domain CAP59_mtransfer PF11735.8 KOS22614.1 - 7.2e-62 209.2 0.0 8.8e-62 208.9 0.0 1.1 1 0 0 1 1 1 1 Cryptococcal mannosyltransferase 1 MFS_1 PF07690.16 KOS22615.1 - 7.2e-25 87.7 61.0 8.5e-17 61.1 32.4 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MS_channel PF00924.18 KOS22616.1 - 4e-12 46.1 7.1 1.8e-11 44.0 7.1 2.0 1 1 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 KOS22616.1 - 0.0018 18.7 0.0 0.0042 17.5 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 KOS22616.1 - 0.003 17.0 0.2 0.0075 15.8 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 KOS22616.1 - 0.023 14.2 0.1 0.023 14.2 0.1 1.9 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 KOS22616.1 - 0.066 13.2 0.0 0.18 11.8 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain DLH PF01738.18 KOS22617.1 - 7.1e-25 87.8 0.0 9.9e-25 87.4 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S15 PF02129.18 KOS22617.1 - 0.031 13.9 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abp2 PF09441.10 KOS22618.1 - 1.8e-39 135.6 0.0 2.3e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 ARS binding protein 2 RNA_pol_A_bac PF01000.26 KOS22619.1 - 1.9e-33 115.2 0.0 2.8e-33 114.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 KOS22619.1 - 4e-17 61.4 0.0 5.3e-17 61.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Sof1 PF04158.14 KOS22620.1 - 1e-31 109.0 15.9 2.1e-31 108.0 15.9 1.5 1 0 0 1 1 1 1 Sof1-like domain WD40 PF00400.32 KOS22620.1 - 8.6e-29 99.2 7.7 8.4e-06 26.4 0.1 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22620.1 - 8.8e-09 35.6 0.3 0.042 14.2 0.1 4.4 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS22620.1 - 1.6e-05 24.1 0.0 0.053 12.5 0.0 3.5 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 KOS22620.1 - 0.0019 16.8 0.1 0.23 10.0 0.1 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 KOS22620.1 - 0.25 10.2 0.5 2.2 7.1 0.1 2.2 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain DUF1481 PF07356.12 KOS22620.1 - 0.41 10.4 5.1 0.45 10.3 0.5 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1481) tRNA-synt_2d PF01409.20 KOS22621.1 - 3.7e-48 164.2 0.6 1.7e-25 89.9 0.0 2.4 3 0 0 3 3 3 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 KOS22621.1 - 1.7e-25 89.3 0.0 3.6e-25 88.2 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain rve_3 PF13683.6 KOS22621.1 - 0.041 13.7 0.1 5.5 6.8 0.0 2.6 2 0 0 2 2 2 0 Integrase core domain Mito_carr PF00153.27 KOS22622.1 - 6.8e-46 154.1 0.3 4.7e-17 61.7 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Neugrin PF06413.11 KOS22623.1 - 4e-11 43.4 0.4 4e-11 43.4 0.4 2.6 2 1 1 3 3 3 1 Neugrin MRP-L20 PF12824.7 KOS22623.1 - 0.0031 17.7 11.6 0.0031 17.7 11.6 2.6 2 1 0 2 2 2 1 Mitochondrial ribosomal protein subunit L20 DUF3612 PF12268.8 KOS22623.1 - 0.07 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3612) Ndc1_Nup PF09531.10 KOS22623.1 - 1 8.0 6.1 1.2 7.8 6.1 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Calcipressin PF04847.12 KOS22624.1 - 8.6e-53 178.8 0.3 1e-52 178.6 0.3 1.0 1 0 0 1 1 1 1 Calcipressin Glyco_hydro_72 PF03198.14 KOS22625.1 - 2.3e-73 247.2 0.5 1.3e-71 241.5 0.5 2.1 1 1 0 1 1 1 1 Glucanosyltransferase adh_short PF00106.25 KOS22626.1 - 6.2e-41 140.0 0.1 8.5e-41 139.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 KOS22626.1 - 9.2e-34 117.0 0.6 1.3e-33 116.5 0.6 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS22626.1 - 6.1e-10 39.3 2.4 6.5e-09 35.9 2.4 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS22626.1 - 0.042 13.3 0.0 0.11 11.9 0.0 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family BioW PF03744.13 KOS22626.1 - 0.054 13.0 0.0 0.078 12.5 0.0 1.2 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase 6PF2K PF01591.18 KOS22627.1 - 3.3e-66 222.8 0.0 1.3e-45 155.5 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 KOS22627.1 - 5.4e-29 101.3 0.0 3e-21 76.0 0.0 2.6 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) KTI12 PF08433.10 KOS22627.1 - 0.009 15.5 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 KOS22627.1 - 0.013 15.6 0.0 0.13 12.4 0.0 2.3 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 KOS22629.1 - 4.9e-24 84.1 9.9 1.7e-09 38.1 1.4 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22629.1 - 8.7e-14 51.6 1.5 0.00016 21.9 0.0 4.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS22629.1 - 1.6e-06 28.1 0.0 2.1e-05 24.5 0.0 2.6 2 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOS22629.1 - 0.00035 19.7 0.3 1.2 8.1 0.0 3.3 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 KOS22629.1 - 0.011 14.5 0.0 0.032 13.0 0.0 1.7 2 0 0 2 2 2 0 Nup133 N terminal like Nup160 PF11715.8 KOS22629.1 - 0.012 14.3 0.3 0.084 11.5 0.1 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 KOS22629.1 - 0.019 13.9 1.6 0.041 12.8 0.5 2.0 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 KOS22629.1 - 0.02 14.3 0.1 1.5 8.1 0.0 3.2 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 KOS22629.1 - 0.079 12.3 0.0 14 4.9 0.0 2.9 2 2 1 3 3 3 0 WD40-like domain Hira PF07569.11 KOS22629.1 - 0.092 12.4 0.4 1.8 8.2 0.0 2.4 3 0 0 3 3 3 0 TUP1-like enhancer of split Cytochrom_D1 PF02239.16 KOS22629.1 - 0.11 11.0 0.7 1.8 7.0 0.7 2.0 1 1 0 1 1 1 0 Cytochrome D1 heme domain Ribosomal_L32p PF01783.23 KOS22630.1 - 2.2e-13 50.2 6.4 3.2e-13 49.7 6.4 1.2 1 0 0 1 1 1 1 Ribosomal L32p protein family Q_salvage PF10343.9 KOS22631.1 - 2.3e-113 378.5 0.0 2.9e-113 378.1 0.0 1.1 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family DNA_pol_delta_4 PF04081.13 KOS22632.1 - 1.4e-16 61.0 1.4 2.3e-16 60.3 1.4 1.3 1 1 0 1 1 1 1 DNA polymerase delta, subunit 4 Glyco_hydro_72 PF03198.14 KOS22633.1 - 4.4e-107 358.0 0.2 5.4e-107 357.7 0.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 KOS22633.1 - 0.00029 20.1 0.2 0.00054 19.2 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 KOS22633.1 - 0.00046 19.7 0.5 0.0013 18.2 0.5 1.7 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Citrate_bind PF16114.5 KOS22634.1 - 2.5e-87 290.9 0.0 3.5e-87 290.5 0.0 1.2 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 KOS22634.1 - 1.5e-08 34.5 0.0 2.5e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain Reovirus_M2 PF05993.12 KOS22634.1 - 0.0013 17.0 0.0 0.0019 16.4 0.0 1.1 1 0 0 1 1 1 1 Reovirus major virion structural protein Mu-1/Mu-1C (M2) Septin PF00735.18 KOS22635.1 - 1.1e-110 369.4 0.2 1.3e-110 369.1 0.2 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 KOS22635.1 - 9.3e-08 32.2 0.0 3.5e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS22635.1 - 2.8e-06 27.4 0.2 0.00017 21.6 0.1 2.3 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 KOS22635.1 - 6.9e-06 25.5 0.0 1.2e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 AIG1 family GTP_EFTU PF00009.27 KOS22635.1 - 0.00024 20.7 0.4 0.017 14.7 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 KOS22635.1 - 0.0014 18.7 0.2 1.8 8.6 0.1 2.5 1 1 0 2 2 2 2 Dynamin family AAA_16 PF13191.6 KOS22635.1 - 0.008 16.6 0.0 0.03 14.7 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 KOS22635.1 - 0.0084 16.6 0.2 0.017 15.6 0.2 1.8 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 KOS22635.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 KOS22635.1 - 0.03 13.7 0.1 0.57 9.5 0.0 2.2 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 KOS22635.1 - 0.035 13.6 0.0 0.1 12.1 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region G-alpha PF00503.20 KOS22635.1 - 0.047 12.9 0.5 0.083 12.0 0.5 1.7 1 1 0 1 1 1 0 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 KOS22635.1 - 0.06 12.7 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Microtub_bd PF16796.5 KOS22635.1 - 0.073 13.0 0.5 0.96 9.4 0.1 2.2 2 0 0 2 2 2 0 Microtubule binding AAA_23 PF13476.6 KOS22635.1 - 0.09 13.3 0.1 0.15 12.6 0.1 1.5 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 KOS22635.1 - 0.094 11.9 0.1 0.16 11.2 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain Roc PF08477.13 KOS22635.1 - 0.1 12.8 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 KOS22635.1 - 0.18 11.6 0.0 0.36 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Guanylate_kin PF00625.21 KOS22636.1 - 2.3e-60 203.4 0.0 2.8e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 KOS22636.1 - 3.6e-05 24.2 0.0 8.4e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 KOS22636.1 - 8.7e-05 22.6 0.0 0.0011 19.0 0.0 2.0 1 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS22636.1 - 0.00044 20.2 0.0 0.0011 18.9 0.0 1.6 2 0 0 2 2 2 1 RsgA GTPase AAA_33 PF13671.6 KOS22636.1 - 0.0041 17.3 0.1 0.039 14.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS22636.1 - 0.0054 17.0 0.0 0.012 15.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 KOS22636.1 - 0.0059 17.1 0.0 0.025 15.1 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 KOS22636.1 - 0.016 15.4 0.1 0.4 10.9 0.1 2.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 KOS22636.1 - 0.057 13.9 0.1 0.46 11.0 0.0 1.9 2 0 0 2 2 2 0 ABC transporter adh_short_C2 PF13561.6 KOS22637.1 - 3.7e-21 75.7 0.4 2.3e-08 33.9 0.0 3.0 2 1 1 3 3 3 3 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS22637.1 - 1.9e-14 53.6 0.3 2.3e-07 30.5 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 KOS22637.1 - 5.1e-08 33.0 0.2 1.4e-07 31.6 0.2 1.7 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS22637.1 - 0.00014 21.4 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DFP PF04127.15 KOS22637.1 - 0.017 15.0 0.1 0.59 9.9 0.1 2.2 2 0 0 2 2 2 0 DNA / pantothenate metabolism flavoprotein NmrA PF05368.13 KOS22637.1 - 0.064 12.8 0.0 0.094 12.3 0.0 1.2 1 0 0 1 1 1 0 NmrA-like family 3HCDH_N PF02737.18 KOS22637.1 - 0.11 12.3 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.21 KOS22638.1 - 4.5e-62 209.6 0.0 5e-62 209.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family UAE_UbL PF14732.6 KOS22638.1 - 7e-19 68.2 1.2 2.1e-18 66.7 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain UBA_e1_thiolCys PF10585.9 KOS22638.1 - 9.6e-05 22.4 3.6 0.00046 20.2 0.2 2.8 1 1 1 2 2 2 1 Ubiquitin-activating enzyme active site Sacchrp_dh_NADP PF03435.18 KOS22638.1 - 0.011 16.0 0.7 0.085 13.1 0.7 2.3 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NAD_binding_7 PF13241.6 KOS22638.1 - 0.08 13.4 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 KOS22638.1 - 0.12 12.4 0.0 0.26 11.3 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase DUF5315 PF17242.2 KOS22639.1 - 5.5e-28 96.6 0.4 1.1e-27 95.7 0.4 1.5 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) Coprogen_oxidas PF01218.18 KOS22640.1 - 1.3e-142 473.8 0.0 1.6e-142 473.6 0.0 1.1 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase CDC45 PF02724.14 KOS22641.1 - 0.04 12.2 13.5 0.054 11.8 13.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 KOS22641.1 - 0.14 12.0 14.3 0.23 11.2 14.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 KOS22641.1 - 0.41 9.4 9.1 0.57 8.9 9.1 1.3 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 KOS22641.1 - 0.7 10.0 7.8 1.5 8.8 7.8 1.5 1 0 0 1 1 1 0 E2F-associated phosphoprotein AAA_11 PF13086.6 KOS22641.1 - 0.97 9.2 9.9 1.5 8.5 9.9 1.2 1 0 0 1 1 1 0 AAA domain CDC27 PF09507.10 KOS22641.1 - 1.1 8.5 21.6 1.6 8.1 21.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Vfa1 PF08432.10 KOS22641.1 - 2.4 8.5 18.8 3.9 7.8 18.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.7 KOS22641.1 - 5.2 5.1 6.1 7.4 4.6 6.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2151 PF10221.9 KOS22641.1 - 8.9 4.8 9.4 12 4.3 9.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator VIR_N PF15912.5 KOS22641.1 - 9.3 5.8 13.3 15 5.1 13.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal PCRF PF03462.18 KOS22642.1 - 3.4e-43 147.8 0.2 7.1e-43 146.7 0.0 1.5 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 KOS22642.1 - 6.4e-35 119.6 2.8 1.2e-34 118.7 2.8 1.4 1 0 0 1 1 1 1 RF-1 domain MFS_1 PF07690.16 KOS22643.1 - 2e-13 50.0 14.6 2.8e-13 49.5 14.6 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DDHD PF02862.17 KOS22643.1 - 2.3e-05 24.7 0.0 2.3e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 DDHD domain DUF5308 PF17233.2 KOS22643.1 - 4e-05 23.9 1.4 4.5e-05 23.7 1.0 1.5 2 0 0 2 2 1 1 Family of unknown function (DUF5308) DUF1266 PF06889.11 KOS22643.1 - 0.00028 21.0 0.4 0.00054 20.0 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1266) EPL1 PF10513.9 KOS22643.1 - 0.00043 20.7 8.1 0.00058 20.3 8.1 1.1 1 0 0 1 1 1 1 Enhancer of polycomb-like Tim54 PF11711.8 KOS22643.1 - 0.0015 17.4 8.6 0.0021 16.9 8.6 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 KOS22643.1 - 0.0018 18.1 4.6 0.0028 17.4 4.6 1.3 1 0 0 1 1 1 1 Connexin GAGA_bind PF06217.12 KOS22643.1 - 0.002 18.5 4.9 0.0026 18.1 4.9 1.1 1 0 0 1 1 1 1 GAGA binding protein-like family CDC45 PF02724.14 KOS22643.1 - 0.003 15.9 5.2 0.0045 15.4 5.2 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF1764 PF08576.10 KOS22643.1 - 0.0063 17.4 7.1 0.011 16.7 7.1 1.3 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) PepSY_TM PF03929.16 KOS22643.1 - 0.0095 15.6 2.8 0.0095 15.6 2.8 1.8 2 0 0 2 2 2 1 PepSY-associated TM region CPSF100_C PF13299.6 KOS22643.1 - 0.021 15.0 8.5 0.034 14.3 8.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Coilin_N PF15862.5 KOS22643.1 - 0.033 14.0 13.8 0.061 13.1 13.8 1.5 1 0 0 1 1 1 0 Coilin N-terminus Ureide_permease PF07168.11 KOS22643.1 - 0.033 12.9 1.7 0.059 12.1 1.7 1.4 1 0 0 1 1 1 0 Ureide permease TFIIA PF03153.13 KOS22643.1 - 0.036 14.1 39.2 0.047 13.7 39.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 KOS22643.1 - 0.044 13.2 17.0 0.062 12.8 17.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) EMC3_TMCO1 PF01956.16 KOS22643.1 - 0.046 13.5 4.7 0.071 12.8 4.7 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Dpy19 PF10034.9 KOS22643.1 - 0.048 11.9 1.2 0.08 11.1 1.2 1.3 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DUF4770 PF15994.5 KOS22643.1 - 0.052 13.8 13.9 0.075 13.3 13.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Spt20 PF12090.8 KOS22643.1 - 0.058 13.0 46.9 0.09 12.4 46.9 1.2 1 0 0 1 1 1 0 Spt20 family CSG2 PF16965.5 KOS22643.1 - 0.063 12.2 2.5 0.085 11.8 2.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Pal1 PF08316.11 KOS22643.1 - 0.079 13.7 2.4 0.11 13.2 2.4 1.2 1 0 0 1 1 1 0 Pal1 cell morphology protein Eapp_C PF10238.9 KOS22643.1 - 0.082 13.0 11.6 0.13 12.3 11.6 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Endostatin PF06482.11 KOS22643.1 - 0.083 12.3 11.3 0.11 12.0 11.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin CTU2 PF10288.9 KOS22643.1 - 0.09 13.0 9.0 0.15 12.3 9.0 1.3 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 eIF-3_zeta PF05091.12 KOS22643.1 - 0.1 11.6 19.0 0.13 11.2 19.0 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4746 PF15928.5 KOS22643.1 - 0.11 11.9 5.9 0.15 11.4 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM91_C PF14648.6 KOS22643.1 - 0.13 11.0 3.7 0.17 10.7 3.7 1.1 1 0 0 1 1 1 0 FAM91 C-terminus V_ATPase_I PF01496.19 KOS22643.1 - 0.14 10.0 13.1 0.17 9.8 13.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family GREB1 PF15782.5 KOS22643.1 - 0.17 9.0 14.8 0.22 8.6 14.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Hid1 PF12722.7 KOS22643.1 - 0.19 9.9 12.2 0.22 9.6 12.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3408 PF11888.8 KOS22643.1 - 0.36 11.0 13.4 0.59 10.3 13.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Presenilin PF01080.17 KOS22643.1 - 0.38 9.5 18.7 0.6 8.8 18.7 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 KOS22643.1 - 0.42 10.4 16.0 0.59 9.9 16.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ndc1_Nup PF09531.10 KOS22643.1 - 0.56 8.8 12.9 0.83 8.3 12.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Cellulose_synt PF03552.14 KOS22643.1 - 0.59 8.5 3.9 0.8 8.1 3.9 1.1 1 0 0 1 1 1 0 Cellulose synthase PAT1 PF09770.9 KOS22643.1 - 0.62 8.3 28.4 0.79 7.9 28.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Lin-8 PF03353.15 KOS22643.1 - 0.66 9.5 18.7 0.89 9.0 18.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 KOS22643.1 - 0.79 9.7 10.9 1.4 8.9 10.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Dynactin_p62 PF05502.13 KOS22643.1 - 0.97 8.1 12.6 1.3 7.7 12.6 1.1 1 0 0 1 1 1 0 Dynactin p62 family LMBR1 PF04791.16 KOS22643.1 - 1 8.2 5.0 1.6 7.6 5.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein MTP18 PF10558.9 KOS22643.1 - 1.2 9.1 10.6 2.2 8.2 10.6 1.4 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) DUF4638 PF15472.6 KOS22643.1 - 1.2 8.8 11.5 1.7 8.3 11.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) FAM176 PF14851.6 KOS22643.1 - 1.2 8.7 12.9 8.6 6.0 11.8 2.2 2 0 0 2 2 2 0 FAM176 family DUF1387 PF07139.11 KOS22643.1 - 1.3 8.7 15.8 1.7 8.3 15.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF913 PF06025.12 KOS22643.1 - 1.4 7.8 11.0 1.9 7.4 11.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Sin_N PF04801.13 KOS22643.1 - 1.5 8.0 22.0 1.9 7.6 22.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region NPR3 PF03666.13 KOS22643.1 - 1.6 7.4 14.1 2.2 7.0 14.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 KOS22643.1 - 1.7 8.0 26.0 2.8 7.3 26.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM222A PF15258.6 KOS22643.1 - 1.7 7.6 30.8 2.3 7.2 30.8 1.1 1 0 0 1 1 1 0 Protein family of FAM222A DUF2076 PF09849.9 KOS22643.1 - 1.7 8.6 34.7 3.3 7.7 34.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SLC12 PF03522.15 KOS22643.1 - 1.9 7.4 15.0 2.6 7.0 15.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NST1 PF13945.6 KOS22643.1 - 2 8.5 22.3 3 7.9 22.3 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator MDM31_MDM32 PF08118.11 KOS22643.1 - 2.1 6.9 8.4 2.7 6.6 8.4 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Rxt3 PF08642.10 KOS22643.1 - 2.5 8.9 7.6 4.3 8.1 7.6 1.4 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 DNApol_Exo PF18136.1 KOS22643.1 - 2.5 7.1 12.2 3.6 6.6 12.2 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF4228 PF14009.6 KOS22643.1 - 2.7 8.3 8.4 4.7 7.6 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) NARP1 PF12569.8 KOS22643.1 - 2.8 6.7 14.9 3.8 6.3 14.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF702 PF05142.12 KOS22643.1 - 3.1 8.3 17.6 5.1 7.6 17.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) Band_3_cyto PF07565.13 KOS22643.1 - 3.4 7.4 15.6 4.7 6.9 15.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2126 PF09899.9 KOS22643.1 - 3.6 5.5 11.8 4.8 5.1 11.8 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) HA2 PF04408.23 KOS22643.1 - 4 7.8 10.5 91 3.4 0.0 2.5 2 0 0 2 2 2 0 Helicase associated domain (HA2) EOS1 PF12326.8 KOS22643.1 - 4.2 7.3 8.9 8.5 6.3 8.9 1.5 1 0 0 1 1 1 0 N-glycosylation protein DUF4834 PF16118.5 KOS22643.1 - 4.4 8.3 22.7 12 7.0 22.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2828 PF11443.8 KOS22643.1 - 4.5 5.2 15.1 6.1 4.8 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Velvet PF11754.8 KOS22643.1 - 4.5 7.1 17.8 6.3 6.7 17.8 1.1 1 0 0 1 1 1 0 Velvet factor CCDC53 PF10152.9 KOS22643.1 - 4.9 7.6 19.2 7.3 7.0 19.2 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Baculo_PP31 PF05311.11 KOS22643.1 - 5.2 6.5 15.1 7.1 6.0 15.1 1.1 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) Sec62 PF03839.16 KOS22643.1 - 5.4 6.5 11.8 8.7 5.8 11.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Paramyxo_ncap PF00973.19 KOS22643.1 - 5.6 5.8 9.5 7.1 5.4 9.5 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Hydin_ADK PF17213.3 KOS22643.1 - 5.6 7.2 12.1 9.5 6.4 12.1 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Membralin PF09746.9 KOS22643.1 - 5.7 5.9 9.1 7.6 5.5 9.1 1.1 1 0 0 1 1 1 0 Tumour-associated protein Peptidase_S64 PF08192.11 KOS22643.1 - 5.7 5.3 14.8 7.6 4.9 14.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Med15 PF09606.10 KOS22643.1 - 6.7 5.3 38.9 11 4.6 38.9 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF1980 PF09323.10 KOS22643.1 - 6.7 6.6 13.9 10 6.0 13.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) FAM60A PF15396.6 KOS22643.1 - 6.9 6.6 12.8 10 6.1 12.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A MMR1 PF08505.10 KOS22643.1 - 7.7 6.7 20.7 10 6.4 20.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein EIIBC-GUT_N PF03612.14 KOS22643.1 - 7.8 6.2 15.1 13 5.5 15.1 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus ALMT PF11744.8 KOS22643.1 - 9.2 5.0 12.8 13 4.5 12.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter YABBY PF04690.13 KOS22643.1 - 9.6 6.7 13.0 16 6.0 13.0 1.3 1 0 0 1 1 1 0 YABBY protein AIF_C PF14721.6 KOS22643.1 - 9.9 6.5 15.2 18 5.7 15.2 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sugar_tr PF00083.24 KOS22644.1 - 1.1e-82 278.3 3.4 1.2e-44 152.9 3.8 2.1 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 KOS22644.1 - 9.5e-29 100.4 14.1 9.5e-29 100.4 14.1 2.4 1 1 1 2 2 2 1 Major Facilitator Superfamily Aminotran_4 PF01063.19 KOS22645.1 - 3.8e-27 95.6 0.0 5e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV CTP_transf_like PF01467.26 KOS22646.1 - 6.4e-09 36.1 0.0 7e-05 23.0 0.0 3.6 3 1 1 4 4 4 3 Cytidylyltransferase-like CTP_transf_like PF01467.26 KOS22647.1 - 2.7e-09 37.4 0.0 3.1e-09 37.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like His_Phos_1 PF00300.22 KOS22648.1 - 1.4e-10 41.2 0.0 4.6e-10 39.5 0.0 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Ribosomal_S24e PF01282.19 KOS22649.1 - 1.6e-33 114.5 0.0 2.7e-33 113.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e RRXRR PF14239.6 KOS22649.1 - 0.00025 20.9 1.6 0.00031 20.6 1.6 1.1 1 0 0 1 1 1 1 RRXRR protein Methyltransf_16 PF10294.9 KOS22650.1 - 1.9e-17 63.6 0.0 3.3e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 KOS22650.1 - 0.0014 18.2 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KOS22650.1 - 0.0019 17.6 0.0 0.0027 17.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 KOS22650.1 - 0.0021 17.8 0.0 0.0033 17.2 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_25 PF13649.6 KOS22650.1 - 0.0032 18.1 0.1 0.0088 16.7 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain DUF938 PF06080.12 KOS22650.1 - 0.009 15.8 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF938) PCMT PF01135.19 KOS22650.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 KOS22650.1 - 0.057 13.3 0.0 0.086 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain DUF1308 PF07000.11 KOS22651.1 - 2.4e-08 34.1 0.0 5.6e-07 29.6 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1308) Ion_trans PF00520.31 KOS22653.1 - 0.00071 18.9 26.5 0.0014 17.9 26.5 1.4 1 1 0 1 1 1 1 Ion transport protein TMEM240 PF15207.6 KOS22653.1 - 0.069 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 TMEM240 family DUF3382 PF11862.8 KOS22653.1 - 0.53 10.6 0.1 0.53 10.6 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3382) PKD_channel PF08016.12 KOS22653.1 - 0.56 8.8 20.7 11 4.5 20.5 2.1 1 1 0 1 1 1 0 Polycystin cation channel Macro PF01661.21 KOS22656.1 - 1.8e-07 31.2 0.0 8.9e-07 29.0 0.0 2.1 2 1 0 2 2 2 1 Macro domain TPR_16 PF13432.6 KOS22657.1 - 1e-08 35.7 0.7 1e-08 35.7 0.7 6.0 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22657.1 - 7.6e-08 31.9 8.7 0.037 14.1 0.0 4.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 KOS22657.1 - 1.2e-07 31.2 0.6 0.1 12.5 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS22657.1 - 4.2e-05 23.6 1.7 0.00019 21.5 0.4 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOS22657.1 - 0.00015 22.2 2.0 0.096 13.2 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22657.1 - 0.00021 21.3 2.0 0.23 11.8 0.0 4.5 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 KOS22657.1 - 0.0025 17.5 0.2 0.24 11.1 0.0 3.8 4 1 1 5 5 5 1 TPR repeat TPR_14 PF13428.6 KOS22657.1 - 0.0039 17.9 16.0 1.2 10.1 0.1 6.5 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22657.1 - 0.0046 17.2 15.2 0.025 14.8 0.0 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 KOS22657.1 - 0.014 15.3 0.7 4.3 7.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 KOS22657.1 - 0.071 12.6 0.0 0.15 11.5 0.0 1.6 1 0 0 1 1 1 0 SHNi-TPR CENP-B_dimeris PF09026.10 KOS22657.1 - 5.4 7.5 22.7 2.4 8.6 1.7 3.6 3 0 0 3 3 3 0 Centromere protein B dimerisation domain ABC_tran PF00005.27 KOS22658.1 - 6.3e-46 156.3 0.4 3.1e-23 82.8 0.0 4.0 3 2 0 3 3 2 2 ABC transporter 4HB PF17947.1 KOS22658.1 - 2.8e-29 101.0 0.9 1.2e-28 99.0 0.0 2.6 3 0 0 3 3 1 1 Four helical bundle domain AAA_21 PF13304.6 KOS22658.1 - 5.2e-18 65.9 0.0 0.0019 18.1 0.0 4.8 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOS22658.1 - 2e-16 60.1 0.0 1.3e-05 24.8 0.0 3.7 2 2 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 KOS22658.1 - 8.2e-10 39.5 4.9 0.00012 22.6 0.1 2.9 3 0 0 3 3 2 2 AAA domain AAA_29 PF13555.6 KOS22658.1 - 1.9e-08 33.9 0.1 0.0047 16.6 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOS22658.1 - 9.6e-08 32.1 0.0 0.0013 18.6 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 KOS22658.1 - 2.4e-07 31.1 0.1 0.0017 18.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain MMR_HSR1 PF01926.23 KOS22658.1 - 4.1e-07 30.1 0.0 0.0036 17.4 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_28 PF13521.6 KOS22658.1 - 1.8e-06 28.3 0.0 0.04 14.1 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 KOS22658.1 - 2.8e-06 27.3 0.7 0.042 13.6 0.0 3.8 5 0 0 5 5 4 2 AAA ATPase domain AAA PF00004.29 KOS22658.1 - 3e-06 27.7 0.0 0.51 10.8 0.0 4.3 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 KOS22658.1 - 5.3e-06 26.7 0.0 0.28 11.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain Dynamin_N PF00350.23 KOS22658.1 - 5.9e-06 26.4 0.0 0.00057 20.0 0.0 2.8 2 0 0 2 2 2 1 Dynamin family MeaB PF03308.16 KOS22658.1 - 1.3e-05 24.4 0.5 0.1 11.5 0.0 2.8 3 0 0 3 3 3 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_18 PF13238.6 KOS22658.1 - 1.4e-05 25.6 0.1 0.16 12.5 0.0 3.5 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 KOS22658.1 - 3.4e-05 24.2 0.0 0.34 11.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_16 PF13191.6 KOS22658.1 - 3.8e-05 24.1 0.0 0.27 11.6 0.0 3.4 2 1 0 2 2 2 2 AAA ATPase domain DUF87 PF01935.17 KOS22658.1 - 0.00017 21.8 0.1 0.31 11.1 0.0 3.7 4 0 0 4 4 3 1 Helicase HerA, central domain PduV-EutP PF10662.9 KOS22658.1 - 0.00023 20.9 0.1 0.25 11.1 0.0 3.1 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation AAA_27 PF13514.6 KOS22658.1 - 0.0003 20.5 0.0 0.13 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 KOS22658.1 - 0.0004 20.0 0.2 0.77 9.3 0.0 3.2 3 0 0 3 3 3 1 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 KOS22658.1 - 0.00042 20.3 0.0 0.19 11.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_24 PF13479.6 KOS22658.1 - 0.00074 19.3 0.5 1.9 8.2 0.0 3.2 3 1 1 4 4 4 2 AAA domain G-alpha PF00503.20 KOS22658.1 - 0.00087 18.5 0.0 0.51 9.4 0.0 2.7 3 0 0 3 3 3 1 G-protein alpha subunit AAA_14 PF13173.6 KOS22658.1 - 0.0012 18.8 0.0 3 7.9 0.0 3.2 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 KOS22658.1 - 0.0024 17.8 0.0 3.6 7.5 0.0 2.7 2 0 0 2 2 2 0 Rad17 P-loop domain Septin PF00735.18 KOS22658.1 - 0.0032 16.8 0.2 1.1 8.5 0.0 3.0 3 0 0 3 3 3 1 Septin AAA_30 PF13604.6 KOS22658.1 - 0.0032 17.2 0.0 3.2 7.4 0.0 3.1 3 0 0 3 3 3 1 AAA domain CLP1_P PF16575.5 KOS22658.1 - 0.0035 17.2 0.0 0.8 9.5 0.0 2.7 2 0 0 2 2 2 1 mRNA cleavage and polyadenylation factor CLP1 P-loop ATPase_2 PF01637.18 KOS22658.1 - 0.0036 17.3 0.1 1.5 8.7 0.0 3.0 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 KOS22658.1 - 0.0036 16.5 0.1 0.27 10.4 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain IstB_IS21 PF01695.17 KOS22658.1 - 0.0067 16.2 0.0 5.5 6.7 0.0 2.9 3 0 0 3 3 2 0 IstB-like ATP binding protein Roc PF08477.13 KOS22658.1 - 0.0089 16.2 0.0 7.1 6.9 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SbcCD_C PF13558.6 KOS22658.1 - 0.0092 16.2 0.0 1.7 8.9 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit ATP_bind_1 PF03029.17 KOS22658.1 - 0.014 15.2 0.1 7.8 6.2 0.0 3.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein HEAT PF02985.22 KOS22658.1 - 0.014 15.6 0.4 46 4.7 0.0 4.3 4 0 0 4 4 3 0 HEAT repeat CLASP_N PF12348.8 KOS22658.1 - 0.018 14.6 0.2 0.87 9.1 0.1 2.5 2 0 0 2 2 2 0 CLASP N terminal AAA_7 PF12775.7 KOS22658.1 - 0.024 14.2 0.0 3.2 7.2 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region PRK PF00485.18 KOS22658.1 - 0.024 14.4 0.0 0.49 10.1 0.0 2.4 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_25 PF13481.6 KOS22658.1 - 0.03 13.9 0.0 2.5 7.6 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 KOS22658.1 - 0.03 14.7 0.1 6.5 7.1 0.0 3.5 3 1 0 3 3 3 0 AAA domain Herpes_ICP4_N PF03584.15 KOS22658.1 - 0.032 14.1 0.2 0.08 12.8 0.2 1.6 1 0 0 1 1 1 0 Herpesvirus ICP4-like protein N-terminal region NTPase_1 PF03266.15 KOS22658.1 - 0.035 14.0 0.0 8.6 6.2 0.0 2.8 2 0 0 2 2 2 0 NTPase ParcG PF10274.9 KOS22658.1 - 0.058 13.5 0.7 11 6.1 0.0 3.0 2 1 1 3 3 3 0 Parkin co-regulated protein Cytidylate_kin PF02224.18 KOS22658.1 - 0.074 12.8 0.0 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Cytidylate kinase Adaptin_N PF01602.20 KOS22658.1 - 0.078 11.5 0.8 0.21 10.1 0.5 1.6 1 1 0 1 1 1 0 Adaptin N terminal region DUF815 PF05673.13 KOS22658.1 - 0.078 12.1 0.0 11 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 KOS22658.1 - 0.088 12.5 0.0 12 5.5 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain T2SSE PF00437.20 KOS22658.1 - 0.1 11.7 0.0 8.1 5.4 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 KOS22658.1 - 0.11 11.8 0.3 13 5.1 0.0 3.2 3 0 0 3 3 3 0 FtsK/SpoIIIE family TsaE PF02367.17 KOS22658.1 - 0.16 12.0 0.0 30 4.6 0.0 2.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 KOS22658.1 - 0.62 8.6 6.1 2.5 6.6 0.0 3.6 5 0 0 5 5 3 0 AAA domain DUF3537 PF12056.8 KOS22659.1 - 0.083 11.7 0.4 0.13 11.1 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) GYF PF02213.16 KOS22660.1 - 2.1e-18 65.7 0.2 4.2e-18 64.7 0.2 1.6 1 0 0 1 1 1 1 GYF domain FAM91_C PF14648.6 KOS22660.1 - 0.24 10.2 7.8 0.41 9.4 7.8 1.3 1 0 0 1 1 1 0 FAM91 C-terminus Connexin PF00029.19 KOS22660.1 - 0.58 9.9 9.2 1.5 8.5 9.2 1.7 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 KOS22660.1 - 1.3 8.7 7.1 5 6.8 7.1 2.0 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 KOS22660.1 - 2.5 5.9 15.4 4.2 5.2 15.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PPL5 PF18168.1 KOS22660.1 - 4.6 6.4 8.8 14 4.9 8.8 1.8 1 0 0 1 1 1 0 Prim-pol family 5 PIP5K PF01504.18 KOS22660.1 - 5.2 6.2 14.1 15 4.7 14.1 1.7 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase Abhydrolase_3 PF07859.13 KOS22661.1 - 8.6e-45 153.2 0.0 9.6e-44 149.8 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 KOS22661.1 - 1.2e-06 27.6 0.0 6.6e-06 25.2 0.0 1.9 1 1 0 1 1 1 1 Steryl acetyl hydrolase Pex14_N PF04695.13 KOS22662.1 - 1.2e-29 104.1 5.1 2.7e-17 63.9 0.3 4.1 2 2 1 3 3 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region ERM PF00769.19 KOS22662.1 - 0.00017 21.5 1.2 0.00023 21.1 1.2 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Prominin PF05478.11 KOS22662.1 - 0.0022 16.1 1.3 0.0028 15.7 1.3 1.1 1 0 0 1 1 1 1 Prominin DUF1043 PF06295.12 KOS22662.1 - 0.0038 17.2 1.9 0.0079 16.2 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) Atg14 PF10186.9 KOS22662.1 - 0.017 14.2 0.1 0.025 13.7 0.1 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CdvA PF18822.1 KOS22662.1 - 0.022 14.6 9.2 0.16 11.8 9.1 2.2 1 1 0 1 1 1 0 CdvA-like coiled-coil domain tRNA-synt_His PF13393.6 KOS22662.1 - 0.078 12.2 0.5 0.39 10.0 0.0 1.9 1 1 1 2 2 2 0 Histidyl-tRNA synthetase zf-C4H2 PF10146.9 KOS22662.1 - 0.083 13.2 7.6 0.21 11.9 7.6 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein NPV_P10 PF05531.12 KOS22662.1 - 0.085 13.3 5.6 0.093 13.2 0.6 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 KOS22662.1 - 0.09 10.3 10.5 0.12 9.9 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HLH PF00010.26 KOS22662.1 - 0.095 12.7 6.3 7.8 6.6 0.8 3.3 1 1 1 2 2 2 0 Helix-loop-helix DNA-binding domain LMBR1 PF04791.16 KOS22662.1 - 0.12 11.2 0.2 0.17 10.8 0.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Baculo_PEP_C PF04513.12 KOS22662.1 - 0.24 11.4 7.9 2.6 8.1 7.7 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 KOS22662.1 - 0.25 11.4 5.0 0.37 10.9 5.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus 5_nucleotid PF05761.14 KOS22662.1 - 0.33 9.8 5.4 0.48 9.3 5.4 1.2 1 0 0 1 1 1 0 5' nucleotidase family FUSC PF04632.12 KOS22662.1 - 0.36 9.3 0.8 0.49 8.9 0.8 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Golgin_A5 PF09787.9 KOS22662.1 - 0.58 9.6 10.6 0.93 8.9 10.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Csm1_N PF18504.1 KOS22662.1 - 1 9.8 7.7 0.75 10.2 4.6 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain Spectrin PF00435.21 KOS22662.1 - 1.1 9.8 8.7 11 6.5 0.4 2.4 1 1 1 2 2 2 0 Spectrin repeat TMPIT PF07851.13 KOS22662.1 - 1.1 8.4 5.4 1.7 7.9 5.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 KOS22662.1 - 1.3 9.1 8.5 0.44 10.6 4.9 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 KOS22662.1 - 2.3 7.0 10.2 3.7 6.4 10.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup88 PF10168.9 KOS22662.1 - 3.7 5.2 7.3 5.4 4.7 7.3 1.1 1 0 0 1 1 1 0 Nuclear pore component Ndc80_HEC PF03801.13 KOS22663.1 - 1.6e-45 154.5 1.8 3.4e-45 153.4 1.8 1.5 1 0 0 1 1 1 1 HEC/Ndc80p family DUF5595 PF18077.1 KOS22663.1 - 0.00057 19.9 5.2 0.00057 19.9 5.2 5.4 6 1 0 6 6 4 1 Domain of unknown function (DUF5595) DUF3966 PF13110.6 KOS22663.1 - 0.0013 18.6 0.7 1 9.3 0.6 2.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3966) Rhomboid_N PF12122.8 KOS22663.1 - 0.0023 18.1 0.6 0.24 11.6 0.1 2.7 2 0 0 2 2 2 1 Cytoplasmic N-terminal domain of rhomboid serine protease DHR10 PF18595.1 KOS22663.1 - 0.0032 17.5 16.0 0.0032 17.5 16.0 3.7 4 0 0 4 4 3 1 Designed helical repeat protein 10 domain TPR_MLP1_2 PF07926.12 KOS22663.1 - 0.0063 16.6 34.9 0.034 14.2 10.6 4.1 3 1 0 3 3 3 2 TPR/MLP1/MLP2-like protein DUF16 PF01519.16 KOS22663.1 - 0.023 15.2 6.5 0.023 15.2 6.5 3.3 2 1 0 2 2 2 0 Protein of unknown function DUF16 Golgin_A5 PF09787.9 KOS22663.1 - 0.062 12.8 42.3 0.8 9.1 5.3 3.8 2 2 2 4 4 4 0 Golgin subfamily A member 5 Filament PF00038.21 KOS22663.1 - 0.069 12.7 38.1 1.4 8.4 17.9 3.0 2 1 0 2 2 2 0 Intermediate filament protein Spc7 PF08317.11 KOS22663.1 - 0.12 11.3 38.2 0.024 13.5 11.6 3.1 3 1 0 3 3 3 0 Spc7 kinetochore protein DUF2935 PF11155.8 KOS22663.1 - 0.19 12.1 3.0 0.79 10.1 0.1 3.1 2 2 0 2 2 2 0 Domain of unknown function (DUF2935) FliJ PF02050.16 KOS22663.1 - 0.37 11.0 28.4 0.081 13.2 5.2 4.0 4 1 0 4 4 3 0 Flagellar FliJ protein DUF4407 PF14362.6 KOS22663.1 - 0.44 9.9 28.0 0.77 9.1 10.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) FlxA PF14282.6 KOS22663.1 - 0.48 10.4 19.2 2.1 8.4 2.1 4.5 3 1 1 4 4 4 0 FlxA-like protein Lebercilin PF15619.6 KOS22663.1 - 0.59 9.8 31.6 0.75 9.4 11.0 3.3 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Ntox28 PF15605.6 KOS22663.1 - 0.69 10.2 12.9 2 8.7 1.4 4.0 3 2 1 4 4 4 0 Bacterial toxin 28 Tropomyosin PF00261.20 KOS22663.1 - 0.84 8.9 42.3 0.5 9.7 12.1 3.3 2 1 0 3 3 3 0 Tropomyosin PepSY_TM_like_2 PF16357.5 KOS22663.1 - 1.1 9.3 0.0 1.1 9.3 0.0 2.8 3 0 0 3 3 3 0 Putative PepSY_TM-like GAS PF13851.6 KOS22663.1 - 1.1 8.6 37.1 0.06 12.7 10.6 3.8 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 KOS22663.1 - 1.5 9.2 29.2 2.2 8.7 2.5 5.3 3 2 3 6 6 6 0 Csm1 N-terminal domain FliD_C PF07195.12 KOS22663.1 - 2 7.7 13.3 1.1 8.6 3.1 3.6 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus FlaC_arch PF05377.11 KOS22663.1 - 2 8.8 21.4 2.1 8.8 0.1 6.0 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) ASPRs PF17641.2 KOS22663.1 - 2.5 8.4 5.2 30 4.9 0.5 2.8 2 0 0 2 2 2 0 Ancylostoma-associated secreted protein related WXG100 PF06013.12 KOS22663.1 - 3 8.1 15.8 17 5.7 1.3 4.7 4 0 0 4 4 4 0 Proteins of 100 residues with WXG HALZ PF02183.18 KOS22663.1 - 3.4 8.0 9.5 0.52 10.6 0.9 4.0 4 0 0 4 4 3 0 Homeobox associated leucine zipper Tropomyosin_1 PF12718.7 KOS22663.1 - 5.8 7.1 46.7 2.4 8.3 17.0 4.1 2 2 1 3 3 3 0 Tropomyosin like FAM76 PF16046.5 KOS22663.1 - 7 5.9 18.2 2.4 7.4 0.0 3.3 3 0 0 3 3 3 0 FAM76 protein Ribosomal_L7Ae PF01248.26 KOS22664.1 - 1.2e-23 82.6 0.1 1.6e-23 82.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF5082 PF16888.5 KOS22664.1 - 0.098 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) Methyltransf_4 PF02390.17 KOS22665.1 - 1.4e-54 184.2 0.0 1.7e-54 183.9 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 KOS22665.1 - 0.0011 19.7 0.0 0.0019 18.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22665.1 - 0.019 15.7 0.0 0.05 14.4 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22665.1 - 0.03 14.1 0.0 0.04 13.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 KOS22665.1 - 0.071 13.1 0.0 0.13 12.3 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 KOS22665.1 - 0.074 12.6 0.0 0.17 11.4 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase small domain Homoserine_dh PF00742.19 KOS22666.1 - 6.7e-52 175.9 0.0 8.7e-52 175.5 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 KOS22666.1 - 2.2e-18 67.0 0.0 3.6e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain CHASE2 PF05226.11 KOS22666.1 - 0.014 15.1 0.0 0.017 14.8 0.0 1.1 1 0 0 1 1 1 0 CHASE2 domain IGPS PF00218.21 KOS22666.1 - 0.11 11.6 0.1 0.18 10.9 0.1 1.3 1 0 0 1 1 1 0 Indole-3-glycerol phosphate synthase DUF4078 PF13300.6 KOS22667.1 - 3.8e-27 94.4 21.6 3.8e-27 94.4 21.6 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4078) APG6_N PF17675.1 KOS22667.1 - 2.3 8.7 13.3 0.21 12.1 7.6 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF5308 PF17233.2 KOS22667.1 - 3.6 7.8 9.6 0.54 10.5 2.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) bZIP_1 PF00170.21 KOS22668.1 - 1.5e-06 28.2 6.0 3.1e-06 27.2 6.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOS22668.1 - 4.5e-06 26.6 9.3 8e-06 25.8 9.3 1.3 1 0 0 1 1 1 1 Basic region leucine zipper TTKRSYEDQ PF10212.9 KOS22668.1 - 0.0079 15.2 0.1 0.0093 15.0 0.1 1.1 1 0 0 1 1 1 1 Predicted coiled-coil domain-containing protein HalX PF08663.10 KOS22668.1 - 0.18 12.1 3.1 0.34 11.3 3.1 1.4 1 0 0 1 1 1 0 HalX domain DCB PF16213.5 KOS22669.1 - 1.7e-49 167.9 3.5 1.2e-47 161.9 2.6 2.9 2 0 0 2 2 2 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 KOS22669.1 - 3.3e-43 147.3 6.3 1.6e-40 138.6 0.0 4.6 4 0 0 4 4 4 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 KOS22669.1 - 6.6e-25 87.4 4.3 1.6e-20 72.9 0.2 4.1 3 1 1 4 4 4 4 C-terminal region of Mon2 protein DUF1981 PF09324.10 KOS22669.1 - 0.00022 21.0 0.1 0.0077 16.1 0.0 3.7 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) Pribosyltran_N PF13793.6 KOS22670.1 - 1.3e-42 144.4 0.3 3.5e-42 143.0 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 KOS22670.1 - 1.6e-39 135.9 1.1 7.2e-32 110.9 0.4 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 KOS22670.1 - 3.2e-15 56.0 0.2 6.7e-15 55.0 0.2 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 KOS22670.1 - 0.0045 16.4 0.0 0.0073 15.8 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PMI_typeI PF01238.21 KOS22672.1 - 1.9e-131 438.7 0.0 2.2e-131 438.5 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 KOS22672.1 - 0.0054 16.6 0.0 0.59 10.0 0.0 2.6 2 0 0 2 2 2 2 AraC-like ligand binding domain Glu-tRNAGln PF02686.15 KOS22675.1 - 8.4e-12 45.2 0.1 2.4e-11 43.7 0.1 1.7 1 1 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit PPI_Ypi1 PF07491.11 KOS22676.1 - 2.3e-21 75.4 9.0 2.3e-21 75.4 9.0 2.6 2 1 0 2 2 2 1 Protein phosphatase inhibitor Cwf_Cwc_15 PF04889.12 KOS22676.1 - 0.14 11.9 4.7 0.25 11.0 4.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Lin-8 PF03353.15 KOS22676.1 - 2.3 7.7 5.7 2.9 7.4 5.7 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ran_BP1 PF00638.18 KOS22677.1 - 4.4e-15 56.0 0.0 9.3e-15 55.0 0.0 1.5 1 1 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 KOS22677.1 - 0.12 12.3 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 WH1 domain Tubulin PF00091.25 KOS22678.1 - 4.8e-68 229.2 0.0 6.9e-68 228.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOS22678.1 - 1.1e-45 154.8 0.4 2.5e-45 153.7 0.2 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOS22678.1 - 1.6e-07 31.7 0.0 3.1e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 KOS22678.1 - 0.077 12.7 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Tubulin domain UPF0160 PF03690.13 KOS22679.1 - 2e-124 415.4 0.0 2.3e-124 415.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Endosulfine PF04667.17 KOS22680.1 - 3.7e-24 84.7 0.2 7.5e-24 83.7 0.1 1.6 1 1 1 2 2 2 1 cAMP-regulated phosphoprotein/endosulfine conserved region MMR_HSR1 PF01926.23 KOS22681.1 - 8.1e-05 22.7 0.0 0.4 10.8 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase L51_S25_CI-B8 PF05047.16 KOS22682.1 - 2.5e-18 65.7 0.4 4.4e-18 64.9 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain HECT PF00632.25 KOS22683.1 - 1.7e-56 191.9 0.0 1.9e-56 191.8 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Nucleoporin_FG PF13634.6 KOS22684.1 - 0.0043 17.9 3.2 0.0043 17.9 3.2 2.7 2 1 0 2 2 2 1 Nucleoporin FG repeat region Pannexin_like PF12534.8 KOS22684.1 - 7.8 5.5 7.9 1.2 8.2 2.8 1.8 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Fungal_trans PF04082.18 KOS22685.1 - 8.1e-22 77.5 0.0 2.5e-21 75.9 0.0 1.7 1 1 0 1 1 1 1 Fungal specific transcription factor domain Acetyltransf_10 PF13673.7 KOS22686.1 - 2.1e-09 37.4 0.0 3.9e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22686.1 - 3.1e-09 37.1 0.1 8e-09 35.8 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS22686.1 - 1e-07 32.2 0.5 1.6e-07 31.6 0.5 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 KOS22686.1 - 0.00057 19.8 0.0 0.0016 18.3 0.0 1.8 2 0 0 2 2 2 1 FR47-like protein Ribosomal_L6 PF00347.23 KOS22687.1 - 1.1e-15 58.1 0.0 1.9e-07 31.7 0.0 2.5 2 1 0 2 2 2 2 Ribosomal protein L6 Tubulin PF00091.25 KOS22688.1 - 7.8e-68 228.6 0.0 2.1e-67 227.2 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOS22688.1 - 4.4e-43 146.4 0.1 7.1e-43 145.8 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOS22688.1 - 7.5e-06 26.3 0.0 2e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KOS22688.1 - 0.0012 18.1 0.0 0.0083 15.3 0.0 2.0 2 0 0 2 2 2 1 Tubulin like Tubulin_3 PF14881.6 KOS22688.1 - 0.0038 16.9 0.0 0.0063 16.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain ABC_tran PF00005.27 KOS22689.1 - 1.8e-47 161.3 0.1 4.9e-22 78.9 0.0 3.3 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 KOS22689.1 - 3.2e-21 75.1 7.0 3.2e-21 75.1 7.0 3.1 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 KOS22689.1 - 1.2e-16 61.4 2.9 0.00077 19.4 0.0 4.4 3 1 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 KOS22689.1 - 1.6e-10 40.8 1.6 0.022 14.2 0.0 4.6 5 0 0 5 5 5 4 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 KOS22689.1 - 3.3e-07 30.4 0.0 0.0043 17.1 0.0 2.9 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_18 PF13238.6 KOS22689.1 - 6.5e-07 30.0 0.0 0.016 15.8 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 KOS22689.1 - 3.6e-06 27.5 0.7 0.007 16.8 0.2 3.0 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 KOS22689.1 - 4.5e-06 26.3 0.3 0.052 13.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS22689.1 - 9.9e-06 26.2 15.5 0.006 17.1 0.1 4.5 5 0 0 5 5 4 2 AAA domain RsgA_GTPase PF03193.16 KOS22689.1 - 1.6e-05 24.9 0.7 0.028 14.3 0.1 3.0 2 1 1 3 3 3 2 RsgA GTPase AAA_33 PF13671.6 KOS22689.1 - 2.2e-05 24.7 0.0 0.2 11.8 0.0 3.0 2 0 0 2 2 2 2 AAA domain MeaB PF03308.16 KOS22689.1 - 3e-05 23.1 0.2 0.25 10.3 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 KOS22689.1 - 4.7e-05 23.3 8.1 0.24 11.1 0.1 4.6 5 0 0 5 5 5 2 AAA ATPase domain AAA_30 PF13604.6 KOS22689.1 - 5.6e-05 22.9 0.3 0.031 14.0 0.0 3.3 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 KOS22689.1 - 6.5e-05 23.2 0.1 0.85 9.9 0.0 3.1 3 1 0 3 3 3 2 AAA domain AAA_24 PF13479.6 KOS22689.1 - 9e-05 22.3 0.2 1 9.1 0.0 3.4 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 KOS22689.1 - 0.0003 21.2 0.0 1 9.8 0.1 3.3 3 1 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 KOS22689.1 - 0.00098 19.2 0.1 2.8 8.0 0.0 3.2 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 KOS22689.1 - 0.0022 18.0 0.1 3.7 7.5 0.0 2.8 3 0 0 3 3 2 2 NACHT domain AAA_28 PF13521.6 KOS22689.1 - 0.0025 18.1 3.7 0.36 11.0 0.0 3.1 3 0 0 3 3 2 1 AAA domain cobW PF02492.19 KOS22689.1 - 0.0033 17.0 0.2 1.1 8.8 0.2 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 KOS22689.1 - 0.0056 16.9 0.1 3 8.1 0.0 2.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase NTPase_1 PF03266.15 KOS22689.1 - 0.0075 16.2 0.0 0.83 9.6 0.0 2.6 2 0 0 2 2 2 1 NTPase RNA_helicase PF00910.22 KOS22689.1 - 0.013 15.8 0.0 8.1 6.9 0.0 2.6 2 0 0 2 2 2 0 RNA helicase MobB PF03205.14 KOS22689.1 - 0.014 15.3 0.3 0.69 9.8 0.1 2.7 3 0 0 3 3 2 0 Molybdopterin guanine dinucleotide synthesis protein B SbcCD_C PF13558.6 KOS22689.1 - 0.016 15.4 1.0 3.2 8.0 0.4 3.6 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit ATP-synt_ab PF00006.25 KOS22689.1 - 0.017 14.8 0.0 0.66 9.6 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 KOS22689.1 - 0.025 13.8 0.0 5.3 6.1 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain SRP54 PF00448.22 KOS22689.1 - 0.042 13.5 0.0 3.7 7.1 0.0 2.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_27 PF13514.6 KOS22689.1 - 0.045 13.3 5.5 3.8 7.0 0.0 3.8 4 1 0 4 4 3 0 AAA domain AAA_7 PF12775.7 KOS22689.1 - 0.049 13.2 0.0 13 5.3 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 KOS22689.1 - 0.054 13.5 0.3 6.6 6.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 KOS22689.1 - 0.058 13.3 0.3 10 6.0 0.0 3.2 2 1 0 3 3 3 0 Rad17 P-loop domain TsaE PF02367.17 KOS22689.1 - 0.1 12.6 0.1 21 5.2 0.1 2.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 KOS22689.1 - 0.41 11.1 5.4 32 5.0 0.1 4.0 4 0 0 4 4 4 0 AAA domain ATP_bind_1 PF03029.17 KOS22689.1 - 0.47 10.2 2.1 20 4.8 0.0 2.9 4 0 0 4 4 2 0 Conserved hypothetical ATP binding protein IstB_IS21 PF01695.17 KOS22689.1 - 1.6 8.4 6.8 12 5.5 0.0 3.7 3 1 0 4 4 3 0 IstB-like ATP binding protein Dynamin_N PF00350.23 KOS22689.1 - 2.6 8.1 10.7 3.9 7.5 0.0 3.8 3 1 0 4 4 4 0 Dynamin family Fe-ADH PF00465.19 KOS22693.1 - 4.7e-38 131.0 0.0 5.5e-38 130.7 0.0 1.1 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 KOS22693.1 - 3.5e-12 46.5 0.0 5.8e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Peripla_BP_6 PF13458.6 KOS22693.1 - 0.018 14.7 0.0 0.022 14.5 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein MR_MLE_C PF13378.6 KOS22694.1 - 3.4e-56 190.3 0.0 5.3e-56 189.6 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 KOS22694.1 - 0.00027 21.1 0.1 0.0005 20.3 0.1 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain MAAL_C PF07476.11 KOS22694.1 - 0.026 13.7 0.0 0.045 12.9 0.0 1.4 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus Abhydrolase_2 PF02230.16 KOS22695.1 - 1.1e-27 97.2 0.0 1.9e-17 63.8 0.0 2.1 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 KOS22695.1 - 3.8e-07 29.8 2.7 1.7e-05 24.4 1.8 2.6 1 1 1 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 KOS22695.1 - 2.8e-05 24.8 14.8 6.4e-05 23.7 14.8 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KOS22695.1 - 0.00076 19.4 0.2 0.0019 18.1 0.2 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold FSH1 PF03959.13 KOS22695.1 - 0.015 14.9 0.0 0.046 13.4 0.0 1.9 1 1 0 1 1 1 0 Serine hydrolase (FSH1) NTP_transf_2 PF01909.23 KOS22695.1 - 0.019 15.3 0.1 0.048 14.0 0.1 1.5 1 1 0 1 1 1 0 Nucleotidyltransferase domain Hydrolase_4 PF12146.8 KOS22695.1 - 0.032 13.5 0.6 0.32 10.2 0.2 2.6 2 1 0 2 2 2 0 Serine aminopeptidase, S33 DLH PF01738.18 KOS22695.1 - 0.057 13.0 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Dienelactone hydrolase family Mannosyl_trans2 PF04188.13 KOS22696.1 - 1e-51 176.7 0.8 2.4e-51 175.4 0.8 1.5 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) PMT PF02366.18 KOS22696.1 - 0.0004 20.1 1.6 0.00094 18.8 1.6 1.6 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase YTH PF04146.15 KOS22697.1 - 5.7e-14 52.4 0.1 8e-14 51.9 0.1 1.2 1 0 0 1 1 1 1 YT521-B-like domain Patched PF02460.18 KOS22698.1 - 6.9e-79 265.9 2.5 3.4e-46 157.8 0.0 2.1 2 0 0 2 2 2 2 Patched family NPC1_N PF16414.5 KOS22698.1 - 3.1e-72 243.0 3.2 4.6e-72 242.5 3.2 1.2 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Sterol-sensing PF12349.8 KOS22698.1 - 3.8e-50 169.7 3.7 3.8e-50 169.7 3.7 2.7 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation MMPL PF03176.15 KOS22698.1 - 4.4e-07 29.1 33.7 0.00035 19.6 12.4 2.5 2 1 0 2 2 2 2 MMPL family Folate_rec PF03024.14 KOS22698.1 - 0.006 16.5 1.0 0.013 15.4 1.0 1.5 1 0 0 1 1 1 1 Folate receptor family Smr PF01713.21 KOS22699.1 - 6.7e-05 23.2 0.4 0.00019 21.7 0.3 1.8 1 1 0 1 1 1 1 Smr domain GvpO PF05800.11 KOS22699.1 - 0.15 12.0 0.5 0.69 9.9 0.1 2.1 2 1 1 3 3 3 0 Gas vesicle synthesis protein GvpO DUF1771 PF08590.10 KOS22699.1 - 0.32 11.4 5.8 0.67 10.4 5.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) LytR_C PF13399.6 KOS22699.1 - 0.47 11.5 2.4 0.97 10.5 0.0 2.3 2 1 0 2 2 2 0 LytR cell envelope-related transcriptional attenuator Rad10 PF03834.14 KOS22700.1 - 5.2e-49 165.0 0.0 7.9e-49 164.4 0.0 1.3 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) TT_ORF2 PF02957.15 KOS22700.1 - 3.9 8.4 6.8 0.25 12.3 0.5 2.0 2 0 0 2 2 2 0 TT viral ORF2 Glyco_hydro_47 PF01532.20 KOS22701.1 - 9.4e-112 374.2 0.0 1.1e-111 374.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 FtsJ PF01728.19 KOS22702.1 - 5e-63 212.4 0.0 7.1e-63 211.9 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Cas_Csy4 PF09618.10 KOS22703.1 - 3.8 7.6 7.8 0.84 9.8 4.0 1.7 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) CAP_N PF01213.19 KOS22703.1 - 4.7 6.6 10.2 13 5.2 10.2 1.7 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Proteasome PF00227.26 KOS22705.1 - 3.4e-47 160.4 0.0 4.7e-47 159.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 KOS22705.1 - 4e-10 39.2 0.1 4e-10 39.2 0.1 1.7 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Tubulin PF00091.25 KOS22706.1 - 7e-69 232.0 0.0 1.2e-68 231.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 KOS22706.1 - 1.5e-39 135.1 0.2 2.4e-39 134.4 0.2 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 KOS22706.1 - 1.9e-07 31.4 0.0 4.6e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 KOS22706.1 - 0.0067 15.7 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Tubulin_3 PF14881.6 KOS22706.1 - 0.024 14.3 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 Tubulin domain PRESAN PF09687.10 KOS22706.1 - 0.051 14.1 0.5 0.051 14.1 0.5 2.2 3 0 0 3 3 3 0 Plasmodium RESA N-terminal IFRD PF05004.13 KOS22707.1 - 1.8e-48 165.2 0.0 2.3e-48 164.9 0.0 1.1 1 0 0 1 1 1 1 Interferon-related developmental regulator (IFRD) DUF5076 PF16826.5 KOS22707.1 - 0.1 12.5 0.1 0.37 10.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5076) Arm PF00514.23 KOS22707.1 - 0.16 12.0 0.1 0.4 10.8 0.1 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat FAD_binding_4 PF01565.23 KOS22708.1 - 1.2e-14 54.3 0.7 3.8e-14 52.6 0.2 2.0 3 0 0 3 3 3 1 FAD binding domain TMEM234 PF10639.9 KOS22709.1 - 4.3e-33 113.8 0.2 5.5e-33 113.5 0.2 1.1 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 KOS22709.1 - 6.7e-05 23.1 9.2 0.00054 20.1 9.2 2.0 1 1 0 1 1 1 1 EamA-like transporter family DUF1211 PF06736.11 KOS22709.1 - 0.035 14.5 0.0 0.079 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1211) WD40 PF00400.32 KOS22710.1 - 1.2e-39 133.5 19.8 1.5e-09 38.3 0.1 7.9 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22710.1 - 1.8e-13 50.6 1.2 0.0058 16.9 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS22710.1 - 1e-07 31.0 4.7 0.085 11.5 0.1 4.1 3 1 1 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 KOS22710.1 - 1.4e-07 30.8 0.3 0.62 9.0 0.0 4.5 2 2 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 KOS22710.1 - 6e-05 22.1 4.3 9.6e-05 21.5 0.1 3.0 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 KOS22710.1 - 0.00012 21.2 0.0 0.00017 20.8 0.0 1.2 1 0 0 1 1 1 1 Coatomer WD associated region Frtz PF11768.8 KOS22710.1 - 0.0034 15.8 0.0 0.008 14.5 0.0 1.6 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 KOS22710.1 - 0.018 14.8 1.4 11 5.7 0.1 3.4 1 1 1 2 2 2 0 TUP1-like enhancer of split HPS3_N PF14761.6 KOS22710.1 - 0.018 14.5 0.0 0.16 11.5 0.0 2.1 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Nbas_N PF15492.6 KOS22710.1 - 0.04 13.3 0.0 6.8 5.9 0.0 3.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal USP7_C2 PF14533.6 KOS22710.1 - 0.051 13.3 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 Ubiquitin-specific protease C-terminal Thioesterase PF00975.20 KOS22711.1 - 7.4e-23 81.9 0.4 3.1e-22 79.8 0.0 2.1 3 0 0 3 3 3 1 Thioesterase domain Abhydrolase_6 PF12697.7 KOS22711.1 - 6.5e-06 26.9 0.1 1.1e-05 26.2 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 KOS22711.1 - 0.02 14.5 0.0 0.067 12.8 0.0 1.8 2 0 0 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 KOS22711.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 KOS22711.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) PGAP1 PF07819.13 KOS22711.1 - 0.19 11.4 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 PGAP1-like protein Asp PF00026.23 KOS22712.1 - 5.1e-13 49.1 0.0 8.1e-13 48.5 0.0 1.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease MFS_1 PF07690.16 KOS22713.1 - 2.2e-37 128.8 58.1 2.1e-34 119.0 36.7 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS22713.1 - 1.5e-06 27.3 22.6 3.9e-06 26.0 22.6 1.6 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1_like PF12832.7 KOS22713.1 - 1.6e-05 24.0 12.3 0.0018 17.2 4.8 2.5 1 1 0 2 2 2 2 MFS_1 like family p450 PF00067.22 KOS22714.1 - 6.8e-44 150.4 0.0 9.5e-44 149.9 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 BACK PF07707.15 KOS22714.1 - 0.041 14.0 0.1 0.21 11.7 0.0 2.0 2 0 0 2 2 2 0 BTB And C-terminal Kelch ESSS PF10183.9 KOS22715.1 - 2.5e-10 40.5 0.0 2.8e-10 40.3 0.0 1.2 1 1 0 1 1 1 1 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Acetyltransf_3 PF13302.7 KOS22716.1 - 1e-26 94.2 0.0 1.6e-26 93.6 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS22716.1 - 7.2e-07 29.5 0.0 9.7e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 KOS22716.1 - 9.2e-06 25.4 0.0 1.4e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOS22716.1 - 0.00017 21.7 0.0 0.00043 20.5 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Exonuc_VIII PF06630.11 KOS22716.1 - 0.18 11.7 0.1 0.26 11.1 0.1 1.2 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII Aminotran_4 PF01063.19 KOS22717.1 - 8.4e-33 114.1 0.0 1.1e-32 113.7 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV MT-A70 PF05063.14 KOS22718.1 - 2.9e-33 115.2 0.0 3.9e-33 114.8 0.0 1.2 1 0 0 1 1 1 1 MT-A70 p450 PF00067.22 KOS22719.1 - 2.9e-23 82.3 0.0 5.1e-23 81.5 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 Aim21 PF11489.8 KOS22720.1 - 2.2e-144 483.1 65.6 2.2e-144 483.1 65.6 3.4 1 1 2 3 3 3 1 Altered inheritance of mitochondria protein 21 Synaptobrevin PF00957.21 KOS22721.1 - 0.0063 16.3 2.4 0.034 14.0 1.4 2.0 1 1 1 2 2 2 2 Synaptobrevin Ysc84 PF04366.12 KOS22722.1 - 3.2e-22 78.6 1.3 5.2e-22 78.0 1.3 1.2 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 KOS22722.1 - 1.4e-10 40.6 0.0 5.5e-10 38.7 0.0 1.9 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 KOS22722.1 - 3.1e-10 39.6 0.0 5.6e-10 38.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 KOS22722.1 - 3.3e-09 36.4 0.0 5.4e-09 35.8 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain gerPA PF10676.9 KOS22722.1 - 0.055 13.7 1.7 1.3 9.3 0.1 2.7 1 1 2 3 3 3 0 Spore germination protein gerPA/gerPF Rcd1 PF04078.13 KOS22723.1 - 1.9e-125 417.4 5.2 2.3e-125 417.1 5.2 1.1 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Med3 PF11593.8 KOS22723.1 - 0.039 13.1 13.5 0.059 12.6 13.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Spt20 PF12090.8 KOS22723.1 - 0.053 13.1 6.1 0.085 12.5 6.1 1.4 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 KOS22723.1 - 0.26 11.2 10.3 0.33 10.9 10.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 KOS22723.1 - 3.5 6.4 11.4 4.9 5.9 11.4 1.1 1 0 0 1 1 1 0 Androgen receptor AMP-binding PF00501.28 KOS22724.1 - 7.1e-81 272.0 0.0 9.2e-81 271.6 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 KOS22724.1 - 5.9e-17 61.5 0.0 9.5e-17 60.8 0.0 1.2 1 0 0 1 1 1 1 Condensation domain PP-binding PF00550.25 KOS22724.1 - 6.8e-15 55.2 0.0 4e-12 46.3 0.0 2.8 2 0 0 2 2 2 2 Phosphopantetheine attachment site AMP-binding_C PF13193.6 KOS22724.1 - 0.00068 20.6 0.0 0.035 15.1 0.0 2.7 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain Pkinase PF00069.25 KOS22725.1 - 4.2e-69 232.8 0.1 4.2e-69 232.8 0.1 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22725.1 - 1.8e-40 138.9 0.1 6e-40 137.2 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 KOS22725.1 - 2.1e-20 72.3 0.2 3.5e-20 71.5 0.2 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 KOS22725.1 - 2.2e-06 26.9 0.0 2.2e-06 26.9 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 KOS22725.1 - 6.8e-05 22.3 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS22725.1 - 0.00014 21.3 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS22725.1 - 0.0029 17.6 0.4 0.016 15.2 0.0 2.2 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 KOS22725.1 - 0.023 14.3 0.0 0.081 12.5 0.0 1.9 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 KOS22725.1 - 0.084 12.4 0.0 0.26 10.8 0.0 1.8 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FBPase PF00316.20 KOS22726.1 - 1.5e-64 216.9 0.1 1.7e-63 213.6 0.1 2.0 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 KOS22726.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Inositol monophosphatase family DUF1604 PF07713.13 KOS22728.1 - 8.9e-40 134.4 0.8 8.9e-40 134.4 0.8 2.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1604) G-patch PF01585.23 KOS22728.1 - 1.2e-06 28.3 2.3 4.7e-06 26.4 0.9 2.5 2 0 0 2 2 2 1 G-patch domain G-patch_2 PF12656.7 KOS22728.1 - 0.0055 16.8 1.3 0.0055 16.8 1.3 2.8 2 1 0 2 2 2 1 G-patch domain SLAIN PF15301.6 KOS22728.1 - 0.61 9.3 2.6 1.5 8.0 2.6 1.5 1 0 0 1 1 1 0 SLAIN motif-containing family NOA36 PF06524.12 KOS22728.1 - 2.4 7.4 6.3 4.5 6.5 6.3 1.4 1 0 0 1 1 1 0 NOA36 protein CIA30 PF08547.12 KOS22729.1 - 1.3e-28 100.0 0.0 8.9e-28 97.3 0.0 1.9 1 1 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) adh_short PF00106.25 KOS22730.1 - 4e-16 59.1 0.0 1.3e-12 47.6 0.0 3.0 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS22730.1 - 1.2e-07 31.6 0.2 2.7e-05 23.9 0.0 2.9 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS22730.1 - 0.00013 21.9 0.1 0.0002 21.3 0.1 1.3 1 0 0 1 1 1 1 KR domain GST_N PF02798.20 KOS22731.1 - 6.3e-09 36.1 0.2 1.5e-08 34.9 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOS22731.1 - 1e-08 35.3 0.1 2.9e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_2 PF13409.6 KOS22731.1 - 1.3e-06 28.6 0.0 2.4e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 KOS22731.1 - 2.9e-06 27.6 0.0 5.5e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOS22731.1 - 5e-05 23.4 0.0 0.00011 22.3 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 KOS22731.1 - 5.1e-05 23.2 0.2 0.00014 21.8 0.2 1.8 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain bZIP_1 PF00170.21 KOS22732.1 - 0.0034 17.5 9.3 0.0057 16.7 9.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 KOS22732.1 - 0.0054 16.8 7.0 0.0099 15.9 7.0 1.4 1 0 0 1 1 1 1 Basic region leucine zipper Striatin PF08232.12 KOS22732.1 - 0.075 13.6 4.0 0.11 13.1 4.0 1.2 1 0 0 1 1 1 0 Striatin family Period_C PF12114.8 KOS22732.1 - 0.23 11.0 9.3 0.41 10.2 9.3 1.3 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Secretin_N_2 PF07655.13 KOS22732.1 - 0.52 10.9 8.0 1 10.0 8.0 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Pox_A12 PF04651.13 KOS22732.1 - 1.9 8.5 8.3 2.9 7.9 8.3 1.2 1 0 0 1 1 1 0 Poxvirus A12 protein MCM_bind PF09739.9 KOS22732.1 - 3.5 6.0 7.6 4.9 5.5 7.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Macoilin PF09726.9 KOS22732.1 - 4.1 5.8 8.5 5.1 5.5 8.5 1.1 1 0 0 1 1 1 0 Macoilin family SDP_N PF12278.8 KOS22732.1 - 5.9 7.0 12.0 10 6.3 12.0 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal Sec3_C PF09763.9 KOS22732.1 - 6.2 5.1 5.5 8 4.7 5.5 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 RAP1 PF07218.11 KOS22732.1 - 6.9 4.8 6.8 9.1 4.4 6.8 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Pkinase PF00069.25 KOS22733.1 - 6.5e-68 229.0 0.0 7.9e-68 228.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22733.1 - 1.1e-31 110.1 0.0 1.6e-31 109.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 KOS22733.1 - 0.0096 14.9 0.0 0.021 13.8 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS22733.1 - 0.035 13.5 0.1 0.074 12.4 0.1 1.5 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 KOS22733.1 - 0.046 13.6 0.1 0.17 11.8 0.0 1.9 2 0 0 2 2 2 0 Phosphotransferase enzyme family LMWPc PF01451.21 KOS22734.1 - 6.5e-40 136.8 0.0 7.3e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase PRELI PF04707.14 KOS22735.1 - 3.8e-43 147.0 0.0 4.7e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family AA_permease PF00324.21 KOS22736.1 - 2.5e-119 399.0 33.1 3e-119 398.8 33.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS22736.1 - 1.1e-35 123.3 32.9 1.5e-35 122.9 32.9 1.1 1 0 0 1 1 1 1 Amino acid permease Hexapep PF00132.24 KOS22737.1 - 2e-09 36.8 6.4 0.00011 21.7 1.6 4.4 3 1 1 4 4 4 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 KOS22737.1 - 0.00016 21.4 1.4 0.00042 20.0 0.4 2.3 3 0 0 3 3 3 1 Hexapeptide repeat of succinyl-transferase Fucokinase PF07959.12 KOS22737.1 - 0.0041 16.1 0.0 0.0057 15.6 0.0 1.2 1 0 0 1 1 1 1 L-fucokinase DUF3455 PF11937.8 KOS22738.1 - 1.2e-30 107.0 0.0 1.5e-30 106.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3455) EF-1_beta_acid PF10587.9 KOS22739.1 - 1.8 9.1 4.9 0.75 10.3 1.9 2.0 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region AhpC-TSA_2 PF13911.6 KOS22740.1 - 6.8e-16 58.4 0.0 1.7e-15 57.1 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme AhpC-TSA PF00578.21 KOS22740.1 - 0.00023 21.1 0.0 0.00062 19.7 0.0 1.6 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOS22740.1 - 0.0045 16.7 0.0 0.01 15.6 0.0 1.4 1 1 0 1 1 1 1 Redoxin Peptidase_M24 PF00557.24 KOS22742.1 - 6.8e-44 150.1 0.1 9.2e-44 149.6 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 PGA2 PF07543.12 KOS22742.1 - 0.28 11.1 3.8 0.88 9.5 3.8 1.8 1 0 0 1 1 1 0 Protein trafficking PGA2 Med3 PF11593.8 KOS22742.1 - 0.96 8.6 4.8 1.4 8.0 4.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Methyltransf_23 PF13489.6 KOS22743.1 - 8.1e-06 25.8 0.0 1.2e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22743.1 - 1e-05 26.2 0.0 2.7e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22743.1 - 0.00075 19.3 0.0 0.002 18.0 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 KOS22743.1 - 0.0021 18.2 0.0 0.46 10.6 0.0 2.2 1 1 1 2 2 2 2 FtsJ-like methyltransferase Methyltransf_11 PF08241.12 KOS22743.1 - 0.011 16.4 0.0 0.021 15.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22743.1 - 0.019 15.7 0.0 0.07 13.9 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Glyco_hydro_92 PF07971.12 KOS22744.1 - 1.8e-138 462.3 4.2 2.1e-138 462.1 4.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOS22744.1 - 3.5e-22 79.5 1.1 7.3e-22 78.4 1.1 1.6 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Trp_DMAT PF11991.8 KOS22745.1 - 3.9e-68 230.5 0.0 5e-68 230.2 0.0 1.1 1 0 0 1 1 1 1 Tryptophan dimethylallyltransferase dCMP_cyt_deam_1 PF00383.23 KOS22747.1 - 1e-26 92.8 1.7 1.4e-26 92.3 1.7 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 KOS22747.1 - 1.5e-08 34.5 0.1 2.8e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase AAA_18 PF13238.6 KOS22747.1 - 9.5e-05 22.9 0.0 0.00032 21.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain CoaE PF01121.20 KOS22747.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Dephospho-CoA kinase ATG7_N PF16420.5 KOS22748.1 - 2.4e-103 345.9 0.0 3.1e-103 345.6 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 KOS22748.1 - 3.7e-43 147.7 0.0 5.4e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 ThiF family PIG-F PF06699.11 KOS22749.1 - 1e-57 195.2 2.5 1e-57 195.2 2.5 1.5 2 0 0 2 2 2 1 GPI biosynthesis protein family Pig-F WD40 PF00400.32 KOS22750.1 - 6e-15 55.4 13.7 0.00063 20.5 0.6 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22750.1 - 2.5e-06 27.7 0.1 4.5 7.6 0.0 5.2 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 KOS22750.1 - 0.0079 15.2 0.2 0.18 10.7 0.1 2.8 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 KOS22750.1 - 0.033 13.5 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 WD40-like domain Itfg2 PF15907.5 KOS22750.1 - 0.037 13.1 0.1 0.06 12.4 0.1 1.3 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 eIF2A PF08662.11 KOS22750.1 - 0.071 13.0 0.2 0.28 11.0 0.0 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A 4HBT_2 PF13279.6 KOS22751.1 - 0.00014 22.3 0.0 0.00021 21.7 0.0 1.3 1 0 0 1 1 1 1 Thioesterase-like superfamily GHMP_kinases_N PF00288.26 KOS22752.1 - 3.8e-10 39.9 0.1 7.3e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 KOS22752.1 - 9.8e-06 25.9 0.0 2.1e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal Cellulase PF00150.18 KOS22753.1 - 2.8e-44 151.7 0.0 3.6e-44 151.3 0.0 1.0 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ribosomal_S2 PF00318.20 KOS22753.1 - 0.19 10.9 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S2 FAD_binding_4 PF01565.23 KOS22754.1 - 1.1e-28 99.6 0.3 1.8e-28 99.0 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain Pkinase PF00069.25 KOS22755.1 - 1e-58 198.8 0.0 1.2e-57 195.3 0.0 2.1 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22755.1 - 9.3e-29 100.5 0.0 1.6e-28 99.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 KOS22755.1 - 0.031 13.6 0.0 0.057 12.7 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 KOS22755.1 - 0.15 11.0 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain SelP_N PF04592.14 KOS22755.1 - 8.2 5.8 10.2 15 4.9 10.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF1325 PF07039.11 KOS22756.1 - 7.7e-36 123.1 0.3 1.3e-35 122.3 0.3 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain DUF21 PF01595.20 KOS22757.1 - 2.4e-34 118.6 0.0 3.8e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 KOS22757.1 - 1.9e-07 31.4 1.4 0.0011 19.4 0.1 3.2 2 0 0 2 2 2 2 CBS domain 2-Hacid_dh_C PF02826.19 KOS22758.1 - 1.5e-33 115.7 1.1 1.4e-16 60.4 0.4 2.4 1 1 1 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOS22758.1 - 4.5e-32 110.5 0.0 9.8e-32 109.4 0.1 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain AlaDh_PNT_C PF01262.21 KOS22758.1 - 0.0023 17.3 0.2 0.0038 16.5 0.2 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ACT PF01842.25 KOS22758.1 - 0.0048 16.6 1.4 0.075 12.8 0.0 3.0 2 1 0 2 2 2 1 ACT domain XdhC_C PF13478.6 KOS22758.1 - 0.01 16.3 0.0 0.021 15.3 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain TrkA_N PF02254.18 KOS22758.1 - 0.095 13.0 0.9 0.25 11.6 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain DUF3421 PF11901.8 KOS22760.1 - 2.2e-18 66.3 0.1 5.5e-18 65.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3421) FH2 PF02181.23 KOS22760.1 - 0.0056 15.8 3.6 0.034 13.3 0.3 2.1 2 0 0 2 2 2 1 Formin Homology 2 Domain DUF684 PF05075.14 KOS22760.1 - 0.077 12.0 0.2 2.9 6.8 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF684) Spc7 PF08317.11 KOS22760.1 - 0.17 10.7 11.7 0.24 10.2 11.7 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF745 PF05335.13 KOS22760.1 - 0.29 10.8 14.9 0.51 10.0 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Mating_N PF12731.7 KOS22760.1 - 0.4 10.8 5.7 0.66 10.1 0.7 2.6 3 0 0 3 3 3 0 Mating-type protein beta 1 Seryl_tRNA_N PF02403.22 KOS22760.1 - 0.73 10.1 5.3 2.5 8.4 0.1 2.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GAS PF13851.6 KOS22760.1 - 1.8 7.9 12.6 1.6 8.0 9.4 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DivIC PF04977.15 KOS22760.1 - 1.9 8.3 5.3 2.8 7.8 2.1 2.5 2 0 0 2 2 2 0 Septum formation initiator Sec8_exocyst PF04048.14 KOS22760.1 - 5.7 6.8 8.4 0.61 10.0 2.5 2.2 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain Drf_GBD PF06371.13 KOS22761.1 - 1.9e-14 53.7 3.0 5.4e-09 35.9 0.0 2.8 2 1 1 3 3 3 2 Diaphanous GTPase-binding Domain Ribosomal_60s PF00428.19 KOS22761.1 - 0.88 10.2 4.8 3 8.5 3.6 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein RraA-like PF03737.15 KOS22762.1 - 6.5e-22 78.3 0.1 1.3e-21 77.4 0.1 1.5 1 1 0 1 1 1 1 Aldolase/RraA Vps36_ESCRT-II PF11605.8 KOS22763.1 - 0.047 13.9 0.0 0.096 12.9 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 UCR_hinge PF02320.16 KOS22764.1 - 3.3e-25 88.1 11.1 3.3e-25 88.1 11.1 2.1 2 0 0 2 2 1 1 Ubiquinol-cytochrome C reductase hinge protein Mpp10 PF04006.12 KOS22764.1 - 0.0027 16.2 17.3 0.0032 16.0 17.3 1.0 1 0 0 1 1 1 1 Mpp10 protein Sigma70_ner PF04546.13 KOS22764.1 - 0.03 14.2 14.4 0.04 13.8 14.4 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF4471 PF14740.6 KOS22764.1 - 0.043 13.0 5.8 0.055 12.7 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) DUF913 PF06025.12 KOS22764.1 - 0.053 12.5 5.5 0.061 12.3 5.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Lin-8 PF03353.15 KOS22764.1 - 0.088 12.4 12.5 0.099 12.2 12.5 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LAP1C PF05609.12 KOS22764.1 - 0.1 11.7 10.3 0.12 11.4 10.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Rxt3 PF08642.10 KOS22764.1 - 0.12 13.1 1.7 0.17 12.7 1.7 1.4 1 1 0 1 1 1 0 Histone deacetylation protein Rxt3 RR_TM4-6 PF06459.12 KOS22764.1 - 0.16 11.7 15.9 0.2 11.4 15.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BUD22 PF09073.10 KOS22764.1 - 0.18 11.1 15.8 0.2 11.0 15.8 1.1 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 KOS22764.1 - 0.18 10.5 12.9 0.22 10.3 12.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 KOS22764.1 - 0.23 10.6 12.4 0.26 10.5 12.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop14 PF04147.12 KOS22764.1 - 0.24 9.6 18.6 0.26 9.5 18.6 1.0 1 0 0 1 1 1 0 Nop14-like family RNase_H2_suC PF08615.11 KOS22764.1 - 0.25 11.5 5.9 0.36 11.0 5.9 1.3 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) RRN3 PF05327.11 KOS22764.1 - 0.36 9.3 10.2 0.39 9.2 10.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 MIF4G_like_2 PF09090.11 KOS22764.1 - 0.43 10.0 8.5 0.47 9.9 8.5 1.1 1 0 0 1 1 1 0 MIF4G like DUF2052 PF09747.9 KOS22764.1 - 0.49 10.5 21.1 0.64 10.1 21.1 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 KOS22764.1 - 0.57 10.4 9.0 0.62 10.2 9.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 KOS22764.1 - 0.61 8.8 8.6 0.66 8.7 8.6 1.0 1 0 0 1 1 1 0 Presenilin Myc_N PF01056.18 KOS22764.1 - 0.76 9.6 17.1 1.1 9.1 17.1 1.3 1 0 0 1 1 1 0 Myc amino-terminal region SDA1 PF05285.12 KOS22764.1 - 0.77 9.1 19.9 0.88 8.9 19.9 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 KOS22764.1 - 1.1 7.5 14.2 1.2 7.4 14.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3391 PF11871.8 KOS22764.1 - 1.4 9.5 12.7 1.7 9.2 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) DUF1682 PF07946.14 KOS22764.1 - 1.5 8.0 12.4 1.8 7.7 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) SpoIIP PF07454.11 KOS22764.1 - 1.6 8.2 10.9 1.8 8.0 10.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SLC12 PF03522.15 KOS22764.1 - 1.6 7.6 5.0 1.8 7.5 5.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 KOS22764.1 - 1.7 7.4 6.5 2.1 7.1 6.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF740 PF05340.12 KOS22764.1 - 2 7.1 14.8 2.3 6.9 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) TFB6 PF17110.5 KOS22764.1 - 2.8 7.6 9.9 3.9 7.2 9.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF4045 PF13254.6 KOS22764.1 - 2.8 7.5 11.4 3.1 7.3 11.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) DNA_pol_phi PF04931.13 KOS22764.1 - 2.9 5.9 26.0 3.3 5.7 26.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 KOS22764.1 - 3.7 8.0 8.4 5.9 7.3 8.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2428 PF10350.9 KOS22764.1 - 4.2 6.6 9.7 5.3 6.2 9.7 1.4 1 1 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) CobT PF06213.12 KOS22764.1 - 4.4 6.6 19.0 4.9 6.5 19.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MscS_TM PF12794.7 KOS22764.1 - 4.5 6.0 6.5 4.6 6.0 6.5 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CLN3 PF02487.17 KOS22764.1 - 4.6 6.2 5.2 5.1 6.0 5.2 1.1 1 0 0 1 1 1 0 CLN3 protein DAP PF15228.6 KOS22764.1 - 5.8 8.1 10.3 12 7.2 10.3 1.6 1 1 0 1 1 1 0 Death-associated protein Sporozoite_P67 PF05642.11 KOS22764.1 - 5.9 4.9 11.6 6.2 4.8 11.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Neur_chan_memb PF02932.16 KOS22764.1 - 8 6.4 8.0 9.3 6.2 8.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Menin PF05053.13 KOS22764.1 - 8.1 4.7 11.9 9.6 4.4 11.9 1.0 1 0 0 1 1 1 0 Menin PBP1_TM PF14812.6 KOS22765.1 - 0.17 12.2 10.1 0.27 11.6 10.1 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 KOS22765.1 - 0.29 10.8 0.8 0.54 9.9 0.8 1.4 1 0 0 1 1 1 0 FAM176 family Nucleo_P87 PF07267.11 KOS22765.1 - 0.39 9.5 1.9 0.51 9.1 1.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RXT2_N PF08595.11 KOS22765.1 - 1.3 9.1 4.6 1.8 8.5 4.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.9 KOS22765.1 - 5.4 6.1 12.1 7.5 5.6 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 KOS22765.1 - 5.7 6.2 13.1 8.2 5.6 13.1 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 KOS22765.1 - 8.8 6.8 15.5 15 6.1 15.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Aminotran_1_2 PF00155.21 KOS22768.1 - 2.7e-94 316.3 0.0 3e-94 316.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II RasGEF PF00617.19 KOS22769.1 - 1.7e-48 165.2 0.0 2.1e-48 164.8 0.0 1.1 1 0 0 1 1 1 1 RasGEF domain CtsR PF05848.11 KOS22769.1 - 0.13 12.2 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Baculo_PEP_C PF04513.12 KOS22770.1 - 0.00068 19.7 3.2 0.0097 16.0 0.2 2.5 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Phospholamban PF04272.14 KOS22770.1 - 0.089 12.3 1.0 1.9 8.0 1.5 2.4 2 0 0 2 2 2 0 Phospholamban Neurensin PF14927.6 KOS22770.1 - 0.13 12.0 0.1 0.44 10.2 0.1 1.9 2 0 0 2 2 2 0 Neurensin DUF975 PF06161.11 KOS22770.1 - 3.5 7.4 7.9 4.7 6.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF975) Trp_syntA PF00290.20 KOS22771.1 - 1.2e-92 309.4 0.0 2.4e-92 308.5 0.0 1.4 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 KOS22771.1 - 3e-50 171.3 0.7 1.4e-49 169.2 0.5 1.9 2 0 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme Ribosomal_L28 PF00830.19 KOS22772.1 - 4.1e-13 49.3 0.4 6.8e-13 48.6 0.4 1.3 1 0 0 1 1 1 1 Ribosomal L28 family MFS_1 PF07690.16 KOS22773.1 - 4.5e-37 127.8 30.6 1.4e-32 113.1 21.5 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOS22773.1 - 0.0012 17.2 0.2 0.0012 17.2 0.2 3.0 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 KOS22773.1 - 0.011 14.6 2.4 0.39 9.5 2.5 3.1 1 1 0 1 1 1 0 MFS_1 like family LacY_symp PF01306.19 KOS22773.1 - 0.27 10.0 9.8 4 6.1 0.1 3.1 3 0 0 3 3 3 0 LacY proton/sugar symporter AA_permease PF00324.21 KOS22774.1 - 2.1e-133 445.4 27.7 2.5e-133 445.2 27.7 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 KOS22774.1 - 4.2e-35 121.4 31.6 5e-35 121.2 31.6 1.1 1 0 0 1 1 1 1 Amino acid permease DUF1741 PF08427.10 KOS22775.1 - 6.3e-85 284.6 0.1 9.7e-85 283.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1741) MFS_1 PF07690.16 KOS22776.1 - 4.4e-18 65.3 32.6 7.8e-18 64.5 32.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 KOS22776.1 - 1.4e-09 37.9 5.6 1.4e-09 37.9 5.6 2.5 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 DUF2304 PF10066.9 KOS22776.1 - 5.2 7.3 9.1 5.9 7.2 1.8 3.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) CN_hydrolase PF00795.22 KOS22777.1 - 2.1e-30 105.9 0.1 5.2e-30 104.6 0.1 1.6 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Acyl-CoA_dh_1 PF00441.24 KOS22778.1 - 4.2e-32 111.4 3.1 6.9e-32 110.7 3.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Cyt-b5 PF00173.28 KOS22778.1 - 1.6e-19 69.8 0.0 3.6e-19 68.7 0.0 1.6 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Acyl-CoA_dh_M PF02770.19 KOS22778.1 - 1.6e-17 63.5 0.1 2.7e-17 62.8 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOS22778.1 - 7.4e-07 29.5 0.9 1.4e-06 28.6 0.9 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOS22778.1 - 1.1e-05 26.0 0.0 2.7e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain zf-CCHC PF00098.23 KOS22779.1 - 1.3e-52 173.6 67.8 4.5e-09 36.0 4.7 7.2 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 KOS22779.1 - 1.7e-12 46.8 42.3 0.0081 15.9 0.5 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_6 PF15288.6 KOS22779.1 - 2.2e-08 33.8 47.5 0.14 12.0 1.2 6.8 3 2 4 7 7 7 6 Zinc knuckle zf-CCHC_3 PF13917.6 KOS22779.1 - 4.2e-08 33.0 50.7 0.076 13.0 2.0 7.1 2 2 5 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 KOS22779.1 - 0.00022 20.8 41.9 0.33 10.7 2.1 7.0 5 2 2 7 7 7 6 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 KOS22779.1 - 0.0032 17.2 1.5 0.0032 17.2 1.5 6.7 7 0 0 7 7 7 3 Zinc knuckle Yae1_N PF09811.9 KOS22780.1 - 1.4e-07 31.1 1.9 2.1e-07 30.5 1.9 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal tRNA-synt_1g PF09334.11 KOS22781.1 - 3.2e-150 500.2 0.0 4.2e-150 499.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 KOS22781.1 - 7.6e-07 27.8 0.0 0.0079 14.5 0.0 3.4 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOS22781.1 - 0.00031 20.7 0.7 0.00064 19.7 0.7 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA Med19 PF10278.9 KOS22781.1 - 0.15 12.0 2.9 0.29 11.1 2.9 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 P_C PF06640.11 KOS22781.1 - 0.89 9.7 5.6 1.6 8.8 5.6 1.3 1 0 0 1 1 1 0 P protein C-terminus NARP1 PF12569.8 KOS22781.1 - 4.3 6.1 10.5 78 2.0 10.4 2.2 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 AhpC-TSA PF00578.21 KOS22782.1 - 1e-24 86.8 0.0 2.2e-24 85.8 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 KOS22782.1 - 3.6e-15 56.0 0.0 1.4e-14 54.1 0.0 1.9 1 0 0 1 1 1 1 Redoxin CDC27 PF09507.10 KOS22782.1 - 0.0017 17.9 51.5 0.0022 17.5 51.5 1.1 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 AhpC-TSA_2 PF13911.6 KOS22782.1 - 0.0026 17.9 0.0 0.016 15.4 0.0 2.1 1 1 1 2 2 2 1 AhpC/TSA antioxidant enzyme CAC1F_C PF16885.5 KOS22782.1 - 0.28 10.8 13.8 0.35 10.5 13.8 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term V_ATPase_I PF01496.19 KOS22782.1 - 0.56 8.1 21.6 0.97 7.3 21.6 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ndc1_Nup PF09531.10 KOS22782.1 - 2.1 7.0 13.2 2.6 6.6 13.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DNA_methylase PF00145.17 KOS22782.1 - 2.9 7.1 17.7 3.9 6.7 17.7 1.1 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase DUF4551 PF15087.6 KOS22782.1 - 4.5 6.0 16.3 5.2 5.8 16.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) MMR1 PF08505.10 KOS22782.1 - 5 7.3 25.7 7.4 6.8 25.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein CI-B14_5a PF07347.12 KOS22783.1 - 0.15 12.0 0.0 0.64 9.9 0.0 1.9 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) UCR_14kD PF02271.16 KOS22784.1 - 6.5e-42 141.6 0.7 7.5e-42 141.4 0.7 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Mito_carr PF00153.27 KOS22785.1 - 1.3e-63 210.9 0.4 1e-21 76.6 0.0 3.4 3 0 0 3 3 3 3 Mitochondrial carrier protein UCH PF00443.29 KOS22787.1 - 8.6e-40 136.8 0.0 1.4e-39 136.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 KOS22787.1 - 2e-08 34.2 0.0 0.00082 19.1 0.0 2.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pkinase PF00069.25 KOS22788.1 - 0.00084 18.8 0.0 5.1 6.4 0.0 3.1 3 0 0 3 3 3 3 Protein kinase domain DUF2461 PF09365.10 KOS22789.1 - 4.7e-74 248.9 0.0 6.3e-74 248.4 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein (DUF2461) Cwf_Cwc_15 PF04889.12 KOS22789.1 - 0.0025 17.6 30.5 0.049 13.4 4.9 3.2 3 0 0 3 3 3 3 Cwf15/Cwc15 cell cycle control protein CTP_transf_like PF01467.26 KOS22790.1 - 1.8e-11 44.4 0.0 2.5e-11 44.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like HSP70 PF00012.20 KOS22791.1 - 5.9e-262 870.2 13.5 6.7e-262 870.0 13.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 KOS22791.1 - 2.1e-16 59.7 2.0 2.1e-15 56.4 0.6 2.1 2 0 0 2 2 2 1 MreB/Mbl protein DDR PF08841.10 KOS22791.1 - 0.0032 16.5 0.3 0.11 11.4 0.1 2.2 2 0 0 2 2 2 1 Diol dehydratase reactivase ATPase-like domain HOIP-UBA PF16678.5 KOS22791.1 - 0.029 14.4 0.7 0.38 10.8 0.0 2.4 2 0 0 2 2 2 0 HOIP UBA domain pair HEPPP_synt_1 PF07307.11 KOS22791.1 - 0.036 13.7 0.8 0.077 12.6 0.8 1.5 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 Hydantoinase_A PF01968.18 KOS22791.1 - 0.065 12.5 3.0 0.15 11.3 0.1 2.7 2 1 1 3 3 3 0 Hydantoinase/oxoprolinase WD40 PF00400.32 KOS22792.1 - 3.6e-11 43.4 3.6 0.0035 18.2 0.1 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22792.1 - 5.5e-05 23.4 0.0 0.64 10.4 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain EIF_2_alpha PF07541.12 KOS22793.1 - 2.1e-37 127.7 0.0 4.2e-37 126.8 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 KOS22793.1 - 4.7e-13 49.3 0.8 9.4e-13 48.3 0.8 1.5 1 0 0 1 1 1 1 S1 RNA binding domain DUF3295 PF11702.8 KOS22794.1 - 4.3e-138 461.8 31.8 5.6e-138 461.4 31.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) DUF1752 PF08550.10 KOS22794.1 - 2.6e-12 46.3 1.4 2.6e-12 46.3 1.4 2.0 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF1752) Mucin PF01456.17 KOS22794.1 - 8.4 6.4 22.8 20 5.2 22.8 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein zf-CHY PF05495.12 KOS22796.1 - 2.3e-10 40.8 8.8 2.3e-10 40.8 8.8 3.4 2 1 0 2 2 2 1 CHY zinc finger RWD PF05773.22 KOS22796.1 - 0.00042 20.6 0.1 0.0019 18.5 0.0 2.0 2 0 0 2 2 2 1 RWD domain Folliculin PF11704.8 KOS22796.1 - 0.068 13.1 0.3 0.11 12.4 0.3 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport tRNA-synt_2 PF00152.20 KOS22797.1 - 3.8e-69 233.2 0.0 4.8e-69 232.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 KOS22797.1 - 0.0027 17.7 0.1 0.0058 16.6 0.1 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain NARP1 PF12569.8 KOS22797.1 - 2.1 7.2 5.6 3.4 6.5 5.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SWIB PF02201.18 KOS22798.1 - 2.3e-20 72.2 0.0 4.5e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 SWIB/MDM2 domain DUF4003 PF13170.6 KOS22798.1 - 0.11 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4003) Mo25 PF08569.11 KOS22799.1 - 4.5e-69 233.3 5.7 5.4e-69 233.1 5.7 1.0 1 0 0 1 1 1 1 Mo25-like SLATT_4 PF18186.1 KOS22799.1 - 0.016 14.8 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 4 RepA_N PF06970.11 KOS22799.1 - 0.027 14.4 0.1 0.064 13.2 0.1 1.6 1 0 0 1 1 1 0 Replication initiator protein A (RepA) N-terminus SNARE PF05739.19 KOS22800.1 - 4.5e-09 36.2 3.6 7.5e-09 35.5 3.6 1.4 1 0 0 1 1 1 1 SNARE domain DUF3446 PF11928.8 KOS22800.1 - 0.024 14.9 5.8 0.041 14.2 5.8 1.3 1 0 0 1 1 1 0 Early growth response N-terminal domain AAA PF00004.29 KOS22800.1 - 0.058 13.8 0.0 0.11 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Med3 PF11593.8 KOS22800.1 - 0.92 8.6 8.0 1.5 7.9 8.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pkinase PF00069.25 KOS22801.1 - 1.2e-66 224.8 0.0 1.6e-66 224.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS22801.1 - 1.3e-34 119.7 0.0 1.1e-24 87.2 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 KOS22801.1 - 7.3e-06 25.5 0.1 0.012 14.9 0.0 2.7 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 KOS22801.1 - 0.0006 18.9 0.0 0.00084 18.4 0.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 KOS22801.1 - 0.0009 18.7 0.0 0.0014 18.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 KOS22801.1 - 0.0013 18.4 0.1 0.71 9.5 0.0 2.1 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 KOS22801.1 - 0.002 18.1 0.1 0.0041 17.1 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family PPTA PF01239.22 KOS22802.1 - 7.3e-39 130.4 14.0 2.4e-09 36.6 1.1 5.3 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat DUF3950 PF13132.6 KOS22802.1 - 0.028 14.2 0.1 5.4 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) Glyco_hydro_18 PF00704.28 KOS22803.1 - 1.8e-90 303.9 12.4 2.1e-90 303.6 12.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 UbiA PF01040.18 KOS22804.1 - 1.3e-11 44.2 3.8 1.6e-11 44.0 3.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family zf-4CXXC_R1 PF10497.9 KOS22805.1 - 0.00028 21.0 23.7 0.025 14.8 23.7 2.5 1 1 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Peptidase_M43 PF05572.13 KOS22805.1 - 0.25 11.3 3.1 9.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Pregnancy-associated plasma protein-A DUF678 PF05077.12 KOS22805.1 - 7.2 6.8 11.3 0.77 9.9 1.3 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF678) tRNA-synt_1 PF00133.22 KOS22806.1 - 4.3e-220 732.0 0.0 2e-219 729.8 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 KOS22806.1 - 2.7e-24 85.9 0.0 6.5e-24 84.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 KOS22806.1 - 1.3e-13 50.5 0.1 5.4e-06 25.4 0.0 3.9 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 KOS22806.1 - 0.0025 17.2 0.0 0.066 12.5 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain OPT PF03169.15 KOS22807.1 - 6e-41 140.8 24.3 1.8e-23 83.0 1.4 3.0 2 1 1 3 3 3 3 OPT oligopeptide transporter protein DUF3270 PF11674.8 KOS22807.1 - 0.03 14.5 0.2 0.03 14.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) TFIIA PF03153.13 KOS22808.1 - 0.033 14.2 13.0 0.041 13.9 13.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 KOS22808.1 - 0.1 12.2 7.2 0.18 11.4 7.2 1.4 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 KOS22808.1 - 4.6 8.3 6.0 40 5.3 1.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RasGAP PF00616.19 KOS22809.1 - 1.4e-29 103.3 6.9 4.5e-22 78.8 0.0 3.8 3 1 1 4 4 4 2 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 KOS22809.1 - 0.00074 19.8 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 C2 domain SR-25 PF10500.9 KOS22809.1 - 0.043 13.4 13.4 0.099 12.2 13.4 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SAE2 PF08573.10 KOS22809.1 - 0.064 14.4 3.3 0.21 12.7 3.3 1.8 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF3915 PF13054.6 KOS22809.1 - 0.46 10.5 3.0 1.6 8.7 3.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) CBFB_NFYA PF02045.15 KOS22809.1 - 4.7 7.9 5.8 14 6.4 5.8 1.8 1 0 0 1 1 1 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B NAD_binding_2 PF03446.15 KOS22810.1 - 2.2e-36 125.4 0.3 4.2e-36 124.5 0.3 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 KOS22810.1 - 2.6e-30 105.2 0.7 6.2e-30 103.9 0.1 2.0 2 0 0 2 2 2 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase F420_oxidored PF03807.17 KOS22810.1 - 5.3e-06 26.9 0.4 1.5e-05 25.5 0.1 1.9 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent OCD_Mu_crystall PF02423.15 KOS22810.1 - 1.5e-05 24.1 0.1 2e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family GFO_IDH_MocA PF01408.22 KOS22810.1 - 0.00024 21.9 0.1 0.0005 20.9 0.1 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold TrkA_N PF02254.18 KOS22810.1 - 0.0086 16.3 0.0 0.019 15.2 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Shikimate_DH PF01488.20 KOS22810.1 - 0.017 15.2 0.1 0.038 14.0 0.0 1.7 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase ATPgrasp_Ter PF15632.6 KOS22810.1 - 0.064 13.0 0.0 0.33 10.7 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp in the biosynthetic pathway with Ter operon KilA-N PF04383.13 KOS22811.1 - 0.0062 16.4 0.0 0.038 13.9 0.0 2.1 1 1 1 2 2 2 1 KilA-N domain DLIC PF05783.11 KOS22811.1 - 0.44 9.3 5.6 0.83 8.4 5.6 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Phage_H_T_join PF05521.11 KOS22811.1 - 3.3 8.3 5.0 18 6.0 2.1 2.8 3 0 0 3 3 3 0 Phage head-tail joining protein Hamartin PF04388.12 KOS22811.1 - 5.4 5.5 11.5 6.6 5.3 11.5 1.2 1 0 0 1 1 1 0 Hamartin protein MAP65_ASE1 PF03999.12 KOS22811.1 - 6.1 5.4 9.4 9.1 4.8 9.4 1.2 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Rho_GDI PF02115.17 KOS22812.1 - 7.5e-64 215.1 0.5 8.2e-64 215.0 0.5 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Metallophos PF00149.28 KOS22813.1 - 9.8e-36 124.2 0.4 1.3e-35 123.8 0.4 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 KOS22813.1 - 0.11 12.9 0.1 0.3 11.6 0.1 1.7 1 0 0 1 1 1 0 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 KOS22813.1 - 0.16 12.2 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain TFIIF_alpha PF05793.12 KOS22814.1 - 3.7 6.0 34.1 4.9 5.6 34.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Fungal_trans_2 PF11951.8 KOS22815.1 - 1e-22 80.5 0.1 1.3e-22 80.2 0.1 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain DUF2107 PF09880.9 KOS22815.1 - 0.06 13.5 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2107) MFS_1 PF07690.16 KOS22816.1 - 5.1e-39 134.2 51.1 2.6e-38 131.9 50.2 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily ORC4_C PF14629.6 KOS22818.1 - 9.3e-50 169.0 0.0 2.2e-41 141.6 0.0 2.3 1 1 1 2 2 2 2 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 KOS22818.1 - 7.3e-14 52.5 0.0 1.6e-13 51.4 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain PHD PF00628.29 KOS22818.1 - 2e-11 43.6 5.5 3.3e-11 42.9 5.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 KOS22818.1 - 6.5e-11 41.6 1.2 6.5e-11 41.6 1.2 2.1 2 0 0 2 2 2 1 PHD-finger AAA PF00004.29 KOS22818.1 - 1.5e-09 38.4 0.0 2.1e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 KOS22818.1 - 9.7e-09 35.6 0.0 1.8e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 KOS22818.1 - 8.4e-06 25.8 0.0 2.7e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 KOS22818.1 - 7.2e-05 22.8 0.0 0.00017 21.6 0.0 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_19 PF13245.6 KOS22818.1 - 0.00069 20.0 0.0 0.0016 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain C1_2 PF03107.16 KOS22818.1 - 0.00071 19.8 1.2 0.012 15.9 0.2 2.5 2 0 0 2 2 2 1 C1 domain NB-ARC PF00931.22 KOS22818.1 - 0.00078 18.7 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain AAA_14 PF13173.6 KOS22818.1 - 0.00093 19.2 0.0 0.0019 18.2 0.0 1.6 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 KOS22818.1 - 0.0011 18.4 0.0 0.71 9.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial TniB protein AAA_30 PF13604.6 KOS22818.1 - 0.0023 17.7 0.0 0.0054 16.5 0.0 1.6 1 1 0 1 1 1 1 AAA domain DUF815 PF05673.13 KOS22818.1 - 0.0031 16.7 0.0 0.0051 16.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) KAP_NTPase PF07693.14 KOS22818.1 - 0.004 16.4 0.0 0.006 15.9 0.0 1.3 1 0 0 1 1 1 1 KAP family P-loop domain AAA_18 PF13238.6 KOS22818.1 - 0.0071 16.9 0.0 0.018 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 KOS22818.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 KOS22818.1 - 0.016 15.7 0.0 0.028 14.9 0.0 1.5 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 KOS22818.1 - 0.025 14.1 0.0 0.046 13.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 KOS22818.1 - 0.028 14.2 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FYVE_2 PF02318.16 KOS22818.1 - 0.033 14.4 0.2 0.067 13.4 0.2 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Rad17 PF03215.15 KOS22818.1 - 0.034 14.1 0.0 0.11 12.4 0.0 1.9 2 0 0 2 2 1 0 Rad17 P-loop domain RNA_helicase PF00910.22 KOS22818.1 - 0.063 13.7 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 KOS22818.1 - 0.071 12.7 0.0 0.13 11.9 0.0 1.5 2 0 0 2 2 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SMC_N PF02463.19 KOS22818.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain T2SSE PF00437.20 KOS22818.1 - 0.11 11.6 0.0 0.17 11.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_25 PF13481.6 KOS22818.1 - 0.11 12.1 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 KOS22818.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DAP3 PF10236.9 KOS22818.1 - 0.11 11.6 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RuvB_N PF05496.12 KOS22818.1 - 0.13 12.0 0.0 0.53 10.0 0.0 2.0 3 0 0 3 3 2 0 Holliday junction DNA helicase RuvB P-loop domain G-alpha PF00503.20 KOS22818.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit Sigma54_activat PF00158.26 KOS22818.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 KOS22818.1 - 0.16 12.1 0.0 0.74 10.0 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 KOS22818.1 - 0.19 11.7 0.0 0.36 10.9 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE cobW PF02492.19 KOS22818.1 - 0.19 11.3 0.0 0.42 10.2 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain TIP49 PF06068.13 KOS22818.1 - 0.21 10.7 0.0 0.33 10.1 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain zf-PHD-like PF15446.6 KOS22818.1 - 0.26 10.9 1.0 0.47 10.0 1.0 1.4 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Prok-RING_1 PF14446.6 KOS22818.1 - 0.69 9.9 5.3 0.52 10.3 3.3 1.9 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 DUF2975 PF11188.8 KOS22821.1 - 0.0037 17.1 0.5 0.0086 16.0 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2975) ASFV_J13L PF05568.11 KOS22821.1 - 0.048 13.4 1.6 0.087 12.6 1.6 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein TMEM154 PF15102.6 KOS22821.1 - 0.051 13.5 0.6 0.077 12.9 0.6 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF4834 PF16118.5 KOS22821.1 - 0.061 14.3 0.7 1.2 10.2 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2615 PF11027.8 KOS22821.1 - 0.14 12.3 3.1 0.2 11.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) Shisa PF13908.6 KOS22821.1 - 0.17 12.1 3.7 0.21 11.8 3.2 1.3 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 KOS22821.1 - 0.23 12.3 1.4 0.59 11.0 0.7 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Sigma_reg_N PF13800.6 KOS22821.1 - 0.48 10.8 4.5 0.83 10.0 4.5 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Protocadherin PF08374.11 KOS22821.1 - 0.48 10.4 1.3 0.59 10.1 0.7 1.4 2 0 0 2 2 2 0 Protocadherin ODV-E18 PF10717.9 KOS22821.1 - 1 9.3 4.9 0.23 11.4 1.6 1.6 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF929 PF06053.11 KOS22821.1 - 1.3 8.3 5.8 1.7 7.9 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) ADH_zinc_N_2 PF13602.6 KOS22822.1 - 1.8e-24 87.3 0.1 4.4e-24 86.0 0.0 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOS22822.1 - 6.9e-14 51.9 0.5 1.2e-13 51.2 0.5 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 KOS22822.1 - 0.016 15.1 0.5 0.03 14.2 0.5 1.4 1 0 0 1 1 1 0 NAD(P)H-binding HEPN_SAV_6107 PF18726.1 KOS22822.1 - 0.11 13.1 9.6 0.17 12.4 0.5 2.6 2 0 0 2 2 2 0 SAV_6107-like HEPN adh_short PF00106.25 KOS22822.1 - 0.12 11.8 0.5 0.18 11.2 0.5 1.3 1 0 0 1 1 1 0 short chain dehydrogenase PhyH PF05721.13 KOS22823.1 - 1.3e-10 41.9 0.0 4.8e-10 40.0 0.0 1.9 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) p450 PF00067.22 KOS22824.1 - 2.5e-25 89.1 0.0 3.2e-25 88.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome P450 Methyltransf_2 PF00891.18 KOS22825.1 - 2.3e-29 102.2 0.0 3.2e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 KOS22825.1 - 0.0083 16.1 0.1 0.1 12.6 0.0 2.4 2 0 0 2 2 2 1 Dimerisation domain Rrf2 PF02082.20 KOS22825.1 - 0.045 14.1 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator HTH_20 PF12840.7 KOS22825.1 - 0.064 13.3 0.9 16 5.7 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain Methyltransf_25 PF13649.6 KOS22825.1 - 0.098 13.4 0.0 0.35 11.6 0.0 2.0 1 0 0 1 1 1 0 Methyltransferase domain DUF5629 PF18629.1 KOS22825.1 - 0.21 12.1 1.1 0.68 10.5 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5629) p450 PF00067.22 KOS22826.1 - 9e-66 222.5 0.0 1.1e-65 222.2 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 DUF218 PF02698.17 KOS22827.1 - 0.00064 19.7 0.0 0.00085 19.3 0.0 1.3 1 0 0 1 1 1 1 DUF218 domain Peptidase_S9 PF00326.21 KOS22828.1 - 9.8e-06 25.2 0.1 0.05 13.1 0.2 2.2 2 0 0 2 2 2 2 Prolyl oligopeptidase family G-patch PF01585.23 KOS22829.1 - 3.4e-07 30.0 0.9 1.3e-06 28.2 0.2 2.3 2 0 0 2 2 2 1 G-patch domain CTU2 PF10288.9 KOS22829.1 - 0.3 11.3 2.3 0.8 10.0 0.0 2.1 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Eapp_C PF10238.9 KOS22829.1 - 0.75 9.9 7.2 0.85 9.7 0.2 2.4 2 1 0 2 2 2 0 E2F-associated phosphoprotein DUF1682 PF07946.14 KOS22829.1 - 5 6.2 13.1 7.4 5.7 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) GST_N_2 PF13409.6 KOS22832.1 - 1.5e-20 73.2 0.2 5.3e-20 71.5 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOS22832.1 - 1.7e-12 47.2 0.0 3.4e-12 46.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS22832.1 - 1e-05 25.7 0.0 5.6e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 KOS22832.1 - 0.0003 21.1 0.0 0.29 11.6 0.0 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 KOS22832.1 - 0.0016 18.6 0.1 0.0042 17.2 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 KOS22832.1 - 0.061 13.9 0.0 0.24 12.0 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Cerato-platanin PF07249.12 KOS22834.1 - 0.025 14.7 0.1 0.099 12.8 0.1 2.1 1 1 0 1 1 1 0 Cerato-platanin GTP_cyclohydro2 PF00925.20 KOS22835.1 - 2.1e-60 203.0 0.0 2.9e-60 202.6 0.0 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase II RPA43_OB PF17875.1 KOS22837.1 - 7.5e-34 117.0 0.0 7.5e-34 117.0 0.0 4.1 2 1 0 2 2 2 1 RPA43 OB domain in RNA Pol I AF-4 PF05110.13 KOS22837.1 - 2.5 6.1 39.4 3.1 5.8 39.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein GFA PF04828.14 KOS22838.1 - 7.7e-06 26.2 8.8 0.00015 22.0 0.0 2.5 2 1 1 3 3 3 2 Glutathione-dependent formaldehyde-activating enzyme NDUF_B7 PF05676.13 KOS22839.1 - 1.1e-30 105.2 5.5 1.3e-30 104.9 5.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) Cmc1 PF08583.10 KOS22839.1 - 0.00043 20.3 1.6 0.00043 20.3 1.6 1.6 2 0 0 2 2 2 1 Cytochrome c oxidase biogenesis protein Cmc1 like SOG2 PF10428.9 KOS22840.1 - 1.5 7.9 5.8 1.7 7.8 5.8 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DIE2_ALG10 PF04922.12 KOS22841.1 - 3.5e-115 385.4 0.1 5.1e-115 384.9 0.1 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family EMP70 PF02990.16 KOS22842.1 - 4.9e-203 675.5 9.0 5.7e-203 675.3 9.0 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 Sas10_Utp3 PF04000.15 KOS22843.1 - 1e-16 61.3 1.5 1e-16 61.3 1.5 2.0 2 0 0 2 2 2 1 Sas10/Utp3/C1D family CDV3 PF15359.6 KOS22843.1 - 0.0074 16.8 5.9 0.0074 16.8 5.9 1.8 2 0 0 2 2 2 1 Carnitine deficiency-associated protein 3 Sporozoite_P67 PF05642.11 KOS22843.1 - 0.28 9.2 2.7 0.28 9.2 0.4 1.9 2 0 0 2 2 2 0 Sporozoite P67 surface antigen DUF4611 PF15387.6 KOS22843.1 - 0.8 10.0 9.6 0.21 11.8 3.9 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) DUF3449 PF11931.8 KOS22843.1 - 5.3 6.8 6.6 1.4 8.7 2.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) QCR10 PF09796.9 KOS22844.1 - 2.1e-19 69.3 0.0 2.6e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Med4 PF10018.9 KOS22845.1 - 9.8e-36 123.3 15.2 2.2e-35 122.1 15.2 1.7 1 1 0 1 1 1 1 Vitamin-D-receptor interacting Mediator subunit 4 TFIIA PF03153.13 KOS22845.1 - 0.002 18.2 17.0 0.0025 17.9 17.0 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DDRGK PF09756.9 KOS22845.1 - 6.6 6.3 19.4 13 5.3 19.4 1.4 1 0 0 1 1 1 0 DDRGK domain CDC45 PF02724.14 KOS22845.1 - 8.5 4.5 8.3 17 3.5 8.3 1.4 1 0 0 1 1 1 0 CDC45-like protein Glyco_transf_15 PF01793.16 KOS22846.1 - 3.3e-129 430.8 4.8 3.9e-129 430.6 4.8 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosom_S12_S23 PF00164.25 KOS22847.1 - 4.1e-29 100.5 0.7 5.4e-29 100.1 0.7 1.2 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Sin_N PF04801.13 KOS22848.1 - 6.9e-21 75.0 0.0 1.6e-20 73.8 0.0 1.4 1 1 0 1 1 1 1 Sin-like protein conserved region PAT1 PF09770.9 KOS22849.1 - 0 1047.0 8.3 6.6e-189 630.1 2.4 3.0 1 1 2 3 3 3 3 Topoisomerase II-associated protein PAT1 FAM176 PF14851.6 KOS22850.1 - 1.6 8.3 8.5 4.2 7.0 0.4 2.4 2 0 0 2 2 2 0 FAM176 family DUF2722 PF10846.8 KOS22850.1 - 8 5.3 10.9 9.8 5.0 5.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Ribosomal_L23 PF00276.20 KOS22851.1 - 3.5e-11 43.3 0.0 6.6e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 RyR PF02026.16 KOS22851.1 - 0.051 13.8 0.5 0.15 12.2 0.3 1.8 2 0 0 2 2 2 0 RyR domain Peptidase_S24 PF00717.23 KOS22852.1 - 0.00017 21.5 0.4 0.00044 20.1 0.4 1.7 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 KOS22852.1 - 0.00063 19.5 0.1 0.29 10.9 0.0 2.5 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Mito_carr PF00153.27 KOS22853.1 - 3.2e-58 193.6 0.0 1.6e-19 69.6 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein DUF383 PF04063.14 KOS22854.1 - 6.3e-68 228.2 0.0 6.5e-67 224.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF383) DUF384 PF04064.13 KOS22854.1 - 7.6e-21 73.7 0.9 1.4e-20 72.9 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF384) Bystin PF05291.11 KOS22855.1 - 1.7e-131 437.9 0.0 2.2e-131 437.5 0.0 1.1 1 0 0 1 1 1 1 Bystin CoA_binding_2 PF13380.6 KOS22857.1 - 5.9e-23 81.6 0.0 6.8e-23 81.4 0.0 1.1 1 0 0 1 1 1 1 CoA binding domain DUF4129 PF13559.6 KOS22857.1 - 0.14 12.4 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Peptidase_M3 PF01432.20 KOS22858.1 - 1.1e-143 479.8 0.0 1.4e-143 479.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 EF-hand_7 PF13499.6 KOS22859.1 - 6.2e-11 42.6 0.1 1.1e-08 35.3 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 KOS22859.1 - 1.6e-10 41.2 0.0 0.00067 19.9 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 KOS22859.1 - 1.4e-08 34.0 0.3 0.008 16.0 0.0 3.9 4 1 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 KOS22859.1 - 8.9e-08 31.2 0.2 0.011 15.3 0.0 4.0 4 1 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 KOS22859.1 - 1.5e-07 31.2 0.0 1.5e-05 24.7 0.0 2.6 1 1 1 2 2 2 2 EF-hand domain pair FGAR-AT_linker PF18072.1 KOS22859.1 - 0.11 13.1 0.2 9.1 6.9 0.2 2.3 2 0 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain 7tm_2 PF00002.24 KOS22860.1 - 2e-07 30.6 9.5 2e-07 30.6 9.5 1.4 2 0 0 2 2 2 1 7 transmembrane receptor (Secretin family) Git3 PF11710.8 KOS22860.1 - 0.027 14.2 11.6 0.049 13.4 11.6 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 DUF4064 PF13273.6 KOS22860.1 - 0.36 11.1 4.3 5 7.4 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Ldh_1_C PF02866.18 KOS22861.1 - 2.2e-46 157.8 0.0 3.6e-46 157.1 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 KOS22861.1 - 2.7e-43 147.4 0.3 2.9e-42 144.1 0.1 2.1 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 KOS22861.1 - 0.0027 16.8 0.0 0.0038 16.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Semialdhyde_dh PF01118.24 KOS22861.1 - 0.0068 16.8 0.5 0.023 15.2 0.0 2.1 3 0 0 3 3 3 1 Semialdehyde dehydrogenase, NAD binding domain zf-C2HC5 PF06221.13 KOS22862.1 - 1.3e-20 73.1 5.5 2e-20 72.5 5.5 1.3 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type SLAC1 PF03595.17 KOS22863.1 - 1.2e-78 264.6 41.3 1.4e-78 264.4 41.3 1.0 1 0 0 1 1 1 1 Voltage-dependent anion channel E1-E2_ATPase PF00122.20 KOS22864.1 - 1.7e-16 60.3 0.0 3.8e-16 59.1 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 KOS22864.1 - 2.3e-16 60.8 1.5 2.1e-10 41.3 1.6 2.9 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 KOS22864.1 - 0.042 13.6 2.9 0.18 11.5 0.0 2.7 3 0 0 3 3 3 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 KOS22864.1 - 0.073 13.2 0.0 0.073 13.2 0.0 2.3 3 0 0 3 3 3 0 Cation transport ATPase (P-type) DUF4059 PF13268.6 KOS22864.1 - 0.14 12.6 2.9 9.6 6.7 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF4059) Pro-kuma_activ PF09286.11 KOS22865.1 - 5e-17 62.5 0.0 2.3e-16 60.4 0.0 2.0 2 0 0 2 2 2 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 KOS22865.1 - 1.8e-06 27.4 0.0 4.8e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 Subtilase family CM_1 PF07736.11 KOS22865.1 - 0.063 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Chorismate mutase type I SIR2 PF02146.17 KOS22866.1 - 6.4e-34 117.4 0.1 7.5e-11 42.3 0.0 3.3 3 0 0 3 3 3 3 Sir2 family SKI PF01202.22 KOS22866.1 - 0.058 13.5 1.2 0.13 12.4 0.0 2.0 1 1 1 2 2 2 0 Shikimate kinase MCM_bind PF09739.9 KOS22866.1 - 4.8 5.5 8.9 11 4.3 8.9 1.5 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SURF2 PF05477.11 KOS22866.1 - 8.6 6.0 12.8 9.4 5.9 9.4 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Whi5 PF08528.11 KOS22867.1 - 1.9e-06 27.3 0.0 3.6e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 Whi5 like Aminotran_5 PF00266.19 KOS22870.1 - 7.9e-21 74.4 0.0 1.1e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Pyridoxal_deC PF00282.19 KOS22870.1 - 0.0015 17.3 0.0 0.0024 16.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Alginate_lyase2 PF08787.11 KOS22871.1 - 2.3e-45 155.3 0.0 2.6e-45 155.1 0.0 1.0 1 0 0 1 1 1 1 Alginate lyase Polysacc_lyase PF14099.6 KOS22871.1 - 0.008 16.0 0.0 0.18 11.6 0.0 2.1 1 1 0 1 1 1 1 Polysaccharide lyase Voltage_CLC PF00654.20 KOS22872.1 - 2.5e-83 280.2 18.8 2.5e-83 280.2 18.8 2.0 2 0 0 2 2 2 1 Voltage gated chloride channel DUF2062 PF09835.9 KOS22872.1 - 0.017 15.0 0.5 0.017 15.0 0.5 3.1 3 1 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2062) LacI PF00356.21 KOS22872.1 - 0.2 11.4 5.5 0.34 10.7 0.3 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, lacI family Glyco_hydro_cc PF11790.8 KOS22873.1 - 3e-39 135.0 0.0 3.4e-39 134.8 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Fip1 PF05182.13 KOS22873.1 - 0.12 11.9 0.4 0.23 11.0 0.4 1.4 1 0 0 1 1 1 0 Fip1 motif Fungal_trans_2 PF11951.8 KOS22874.1 - 6.7e-07 28.4 0.2 1.1e-06 27.8 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain SAC3_GANP PF03399.16 KOS22875.1 - 9e-25 87.6 2.7 9.4e-23 81.0 2.7 2.1 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 KOS22875.1 - 0.0016 18.5 0.1 0.0041 17.1 0.0 1.7 2 0 0 2 2 2 1 CSN8/PSMD8/EIF3K family DUF3381 PF11861.8 KOS22875.1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) EAP30 PF04157.16 KOS22876.1 - 3.4e-39 134.5 0.0 4.5e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 EAP30/Vps36 family Vps36_ESCRT-II PF11605.8 KOS22876.1 - 2.7e-23 82.0 0.0 4.9e-23 81.1 0.0 1.4 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 Vps36-NZF-N PF16988.5 KOS22876.1 - 7.2e-22 76.6 1.5 7.2e-22 76.6 1.5 2.6 2 1 0 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-RanBP PF00641.18 KOS22876.1 - 0.00066 18.9 0.8 0.00066 18.9 0.8 2.6 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 KOS22876.1 - 0.0083 16.2 6.1 0.053 13.6 0.4 2.4 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger GRAM PF02893.20 KOS22876.1 - 0.038 13.9 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 GRAM domain DZR PF12773.7 KOS22876.1 - 0.33 11.0 4.3 0.21 11.7 0.3 2.4 3 0 0 3 3 3 0 Double zinc ribbon HTH_ABP1_N PF18107.1 KOS22877.1 - 4.6e-24 83.9 2.4 4.6e-24 83.9 2.4 2.8 3 1 0 3 3 3 1 Fission yeast centromere protein N-terminal domain HTH_Tnp_Tc5 PF03221.16 KOS22877.1 - 4.6e-18 65.0 2.0 3.3e-17 62.3 0.2 2.8 2 1 1 3 3 3 1 Tc5 transposase DNA-binding domain SUIM_assoc PF16619.5 KOS22877.1 - 1.2e-12 47.6 0.0 1.7e-07 31.2 0.0 4.9 3 1 2 5 5 5 1 Unstructured region C-term to UIM in Ataxin3 TFIIA PF03153.13 KOS22877.1 - 0.0025 17.9 26.3 0.0025 17.9 26.3 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit PRCC PF10253.9 KOS22877.1 - 0.16 12.7 31.6 0.32 11.8 22.5 2.2 2 0 0 2 2 2 0 Mitotic checkpoint regulator, MAD2B-interacting CDK5_activator PF03261.15 KOS22877.1 - 3 7.3 17.8 1.9 7.9 7.8 2.1 2 0 0 2 2 2 0 Cyclin-dependent kinase 5 activator protein Neur_chan_memb PF02932.16 KOS22877.1 - 3 7.8 11.2 0.12 12.4 3.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Velvet PF11754.8 KOS22877.1 - 4.8 7.0 19.4 0.97 9.3 10.3 2.3 2 0 0 2 2 2 0 Velvet factor PAT1 PF09770.9 KOS22877.1 - 6.3 4.9 32.3 0.035 12.4 21.7 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 KOS22877.1 - 8.2 5.0 22.1 0.36 9.5 10.8 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup ATP19 PF11022.8 KOS22878.1 - 1e-26 93.1 0.1 1.2e-26 92.9 0.1 1.0 1 0 0 1 1 1 1 ATP synthase subunit K MTP18 PF10558.9 KOS22879.1 - 5.8e-82 273.7 0.1 7.7e-82 273.4 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial 18 KDa protein (MTP18) zf-AN1 PF01428.16 KOS22880.1 - 1e-23 83.2 23.7 6.5e-12 45.4 9.1 2.2 2 0 0 2 2 2 2 AN1-like Zinc finger IBR PF01485.21 KOS22880.1 - 0.072 13.3 17.9 0.098 12.9 2.5 2.7 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Transp_Tc5_C PF04236.15 KOS22880.1 - 1.3 9.4 14.0 1.1 9.6 4.9 2.3 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Rad4 PF03835.15 KOS22881.1 - 8.5e-30 103.4 0.0 8.5e-30 103.4 0.0 2.3 3 0 0 3 3 3 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 KOS22881.1 - 3.3e-27 94.7 0.4 1.1e-26 93.0 0.5 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 KOS22881.1 - 5.2e-20 71.0 0.5 1.2e-19 69.8 0.5 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 BHD_2 PF10404.9 KOS22881.1 - 3.1e-14 53.7 0.1 3.1e-14 53.7 0.1 6.4 6 3 0 6 6 6 1 Rad4 beta-hairpin domain 2 Transglut_core PF01841.19 KOS22881.1 - 0.01 16.3 0.1 0.078 13.4 0.0 2.5 2 1 0 2 2 2 1 Transglutaminase-like superfamily SMYLE_N PF18615.1 KOS22881.1 - 6 6.3 8.6 0.4 10.2 1.4 2.1 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Dcc1 PF09724.9 KOS22882.1 - 1.9e-12 47.2 0.0 2.1e-12 47.0 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 SH3_1 PF00018.28 KOS22884.1 - 2e-28 97.7 0.0 2.5e-14 52.6 0.0 2.7 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 KOS22884.1 - 4.3e-20 71.3 0.3 7.2e-11 41.8 0.1 3.0 3 0 0 3 3 3 2 Variant SH3 domain PX PF00787.24 KOS22884.1 - 1.3e-13 51.0 0.0 2.3e-13 50.1 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 KOS22884.1 - 4.1e-11 42.4 0.0 5.6e-07 29.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain PB1 PF00564.24 KOS22884.1 - 2.7e-08 33.6 0.0 5e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 PB1 domain Chorismate_bind PF00425.18 KOS22885.1 - 1.3e-89 300.2 0.0 1.8e-89 299.7 0.0 1.2 1 0 0 1 1 1 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 KOS22885.1 - 2.1e-23 83.1 0.0 1.5e-19 70.6 0.0 4.2 3 2 1 4 4 4 2 Anthranilate synthase component I, N terminal region IMS PF00817.20 KOS22886.1 - 1e-36 126.2 0.0 1.5e-36 125.6 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KOS22886.1 - 7.6e-11 42.7 0.0 1.4e-10 41.9 0.0 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 KOS22886.1 - 0.15 12.5 0.0 0.42 11.0 0.0 1.9 1 0 0 1 1 1 0 IMS family HHH motif SR-25 PF10500.9 KOS22888.1 - 0.0066 16.1 5.0 0.0066 16.1 5.0 2.7 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein DUF4667 PF15700.5 KOS22888.1 - 0.011 15.9 18.5 0.088 12.9 10.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4667) TPR_1 PF00515.28 KOS22889.1 - 2e-55 182.4 37.8 2.5e-08 33.4 0.1 10.8 11 1 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22889.1 - 1.9e-49 161.8 26.1 8.3e-06 25.5 1.1 10.5 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 KOS22889.1 - 6e-35 116.5 23.4 0.00024 21.1 0.9 10.9 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.6 KOS22889.1 - 4.3e-31 105.0 20.4 0.0006 20.0 0.1 10.0 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_19 PF14559.6 KOS22889.1 - 4.6e-28 97.5 20.8 5.4e-06 26.8 0.4 7.4 3 3 4 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 KOS22889.1 - 5.5e-28 97.3 16.0 3.1e-07 30.9 0.5 6.8 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 KOS22889.1 - 2.4e-27 93.2 13.0 3.7e-05 24.2 0.0 9.0 2 2 7 9 9 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 KOS22889.1 - 6.3e-27 93.0 30.7 6.7e-07 28.9 0.3 10.2 5 3 5 10 10 10 8 TPR repeat TPR_6 PF13174.6 KOS22889.1 - 8.6e-23 79.4 17.4 0.0063 17.1 0.7 9.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_12 PF13424.6 KOS22889.1 - 5.6e-22 77.8 25.0 9.2e-06 25.9 0.7 7.7 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 KOS22889.1 - 3e-19 67.6 12.4 0.0049 16.8 0.0 9.4 9 1 0 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 KOS22889.1 - 1.3e-18 66.9 8.5 0.00035 20.7 0.1 6.0 1 1 3 6 6 6 6 Tetratricopeptide repeat TPR_15 PF13429.6 KOS22889.1 - 1.8e-13 50.3 9.4 0.0015 17.9 0.4 5.7 1 1 5 6 6 6 5 Tetratricopeptide repeat ANAPC3 PF12895.7 KOS22889.1 - 1.4e-10 41.2 15.4 7.3e-09 35.7 2.6 3.7 3 1 3 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 KOS22889.1 - 5.4e-08 32.8 11.1 0.028 14.1 4.0 5.2 3 2 2 5 5 5 3 Tetratricopeptide repeat-like domain DUF2225 PF09986.9 KOS22889.1 - 0.00012 21.9 3.5 0.018 14.8 0.1 3.4 2 2 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_20 PF14561.6 KOS22889.1 - 0.0017 18.7 5.3 0.26 11.7 0.1 4.2 3 2 2 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 KOS22889.1 - 0.0044 17.1 0.4 6.3 7.0 0.0 4.6 5 0 0 5 5 4 1 Fis1 C-terminal tetratricopeptide repeat BTAD PF03704.17 KOS22889.1 - 0.01 16.3 8.6 1 9.8 0.2 3.3 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 KOS22889.1 - 0.029 14.2 22.5 7 6.7 0.0 8.1 10 0 0 10 10 9 0 Tetratricopeptide repeat SNAP PF14938.6 KOS22889.1 - 0.13 11.6 18.0 7.6 5.9 3.1 5.1 2 2 2 5 5 5 0 Soluble NSF attachment protein, SNAP MLD PF11647.8 KOS22889.1 - 0.15 12.4 0.1 0.79 10.1 0.1 2.2 2 0 0 2 2 2 0 Membrane Localization Domain ChAPs PF09295.10 KOS22889.1 - 0.21 10.5 1.2 11 5.0 0.1 2.6 2 1 0 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Ribosomal_L3 PF00297.22 KOS22890.1 - 8e-184 610.8 10.9 9.1e-184 610.6 10.9 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 WD40 PF00400.32 KOS22891.1 - 2.5e-12 47.1 2.6 0.021 15.7 0.0 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS22891.1 - 7.2e-08 32.6 0.1 0.0003 21.0 0.0 4.6 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 KOS22891.1 - 7.4e-07 28.9 0.1 1.4e-06 28.0 0.1 1.5 1 0 0 1 1 1 1 LisH eIF2A PF08662.11 KOS22891.1 - 0.18 11.7 0.1 7.4 6.4 0.0 3.0 4 0 0 4 4 4 0 Eukaryotic translation initiation factor eIF2A SPX PF03105.19 KOS22891.1 - 1.8 8.4 7.7 2.6 7.9 7.7 1.1 1 0 0 1 1 1 0 SPX domain DUF1751 PF08551.10 KOS22892.1 - 6e-26 90.9 4.9 1.1e-25 90.0 4.9 1.5 1 0 0 1 1 1 1 Eukaryotic integral membrane protein (DUF1751) Rhomboid PF01694.22 KOS22892.1 - 2.9 7.9 11.8 5.3 7.0 11.8 1.4 1 0 0 1 1 1 0 Rhomboid family Reprolysin_5 PF13688.6 KOS22893.1 - 8.8e-56 189.2 0.2 8.8e-56 189.2 0.2 2.3 3 1 0 3 3 3 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 KOS22893.1 - 2.4e-47 161.3 0.0 4.8e-47 160.4 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 KOS22893.1 - 2.5e-41 141.6 0.0 5.5e-41 140.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Disintegrin PF00200.23 KOS22893.1 - 1.9e-17 63.8 33.2 1.9e-17 63.8 33.2 4.5 3 2 1 4 4 4 1 Disintegrin Reprolysin_3 PF13582.6 KOS22893.1 - 8.7e-10 39.2 0.4 4.1e-09 37.0 0.0 2.3 2 1 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like ADAM_CR_2 PF17771.1 KOS22893.1 - 1.9e-05 25.1 10.1 1.9e-05 25.1 10.1 4.1 1 1 2 3 3 3 1 ADAM cysteine-rich domain Pep_M12B_propep PF01562.19 KOS22893.1 - 0.024 14.9 0.1 0.043 14.0 0.1 1.3 1 0 0 1 1 1 0 Reprolysin family propeptide tRNA_SAD PF07973.14 KOS22895.1 - 2.6e-06 27.4 0.2 5e-06 26.5 0.2 1.4 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 KOS22895.1 - 0.0012 17.4 0.0 0.0018 16.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (A) Aldedh PF00171.22 KOS22896.1 - 2.4e-137 458.2 0.0 3.1e-137 457.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ABC2_membrane PF01061.24 KOS22897.1 - 7.9e-72 241.1 70.7 3.8e-37 127.7 25.5 2.9 3 1 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 KOS22897.1 - 2.7e-20 72.0 10.1 4.7e-16 58.5 0.1 3.1 3 0 0 3 3 3 2 CDR ABC transporter ABC_tran PF00005.27 KOS22897.1 - 3.3e-11 43.8 0.0 0.00025 21.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 KOS22897.1 - 5.2e-09 35.7 14.0 5.2e-09 35.7 14.0 2.9 2 0 0 2 2 2 2 ABC-2 family transporter protein AAA_21 PF13304.6 KOS22897.1 - 0.097 12.5 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Methyltransf_23 PF13489.6 KOS22898.1 - 4e-18 65.8 0.0 5.6e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22898.1 - 1.6e-12 48.0 0.0 3.7e-12 46.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22898.1 - 8.4e-11 42.4 0.0 1.6e-10 41.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22898.1 - 1.4e-08 35.4 0.0 7.9e-08 33.0 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22898.1 - 1.5e-07 31.3 0.0 0.00019 21.3 0.0 2.1 2 0 0 2 2 2 2 Methyltransferase domain Ubie_methyltran PF01209.18 KOS22898.1 - 1.5e-06 27.7 0.0 1.8e-05 24.2 0.0 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 KOS22898.1 - 0.00043 19.9 0.0 0.0009 18.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KOS22898.1 - 0.0046 16.4 0.0 0.0066 15.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 KOS22898.1 - 0.0083 15.6 0.0 0.017 14.6 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_16 PF10294.9 KOS22898.1 - 0.011 15.4 0.0 0.017 14.9 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF938 PF06080.12 KOS22898.1 - 0.038 13.7 0.0 0.057 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_2 PF00891.18 KOS22898.1 - 0.045 13.1 0.0 0.082 12.2 0.0 1.5 1 1 0 1 1 1 0 O-methyltransferase domain CMAS PF02353.20 KOS22898.1 - 0.15 11.3 0.0 0.41 9.9 0.0 1.8 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 KOS22898.1 - 0.19 11.8 0.1 0.8 9.8 0.0 1.8 2 0 0 2 2 2 0 FtsJ-like methyltransferase ERCC4 PF02732.15 KOS22899.1 - 6.5e-26 91.4 0.0 8.3e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 ERCC4 domain TrpBP PF02081.15 KOS22899.1 - 0.1 12.4 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein His_Phos_1 PF00300.22 KOS22900.1 - 2.1e-26 92.9 0.6 8e-26 90.9 0.6 1.7 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DNA_binding_1 PF01035.20 KOS22901.1 - 4.3e-18 65.2 0.1 6.8e-18 64.6 0.1 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Dak1 PF02733.17 KOS22901.1 - 0.02 13.8 0.0 0.021 13.7 0.0 1.1 1 0 0 1 1 1 0 Dak1 domain Kinesin PF00225.23 KOS22902.1 - 1.2e-91 307.1 0.0 1.2e-91 307.1 0.0 3.8 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 KOS22902.1 - 3.2e-20 72.6 2.1 5.1e-17 62.2 0.0 3.9 3 1 1 4 4 4 2 Microtubule binding DNA_Packaging PF11053.8 KOS22902.1 - 0.00059 19.7 0.4 0.0025 17.7 0.4 2.1 1 0 0 1 1 1 1 Terminase DNA packaging enzyme KASH_CCD PF14662.6 KOS22902.1 - 0.0043 16.9 15.5 0.0043 16.9 15.5 9.8 6 3 3 9 9 9 1 Coiled-coil region of CCDC155 or KASH MamL-1 PF09596.10 KOS22902.1 - 2.5 8.4 10.7 4.2 7.7 1.7 4.6 3 0 0 3 3 3 0 MamL-1 domain ASCH PF04266.14 KOS22902.1 - 6 7.5 8.4 1.4 9.5 0.3 3.9 3 0 0 3 3 3 0 ASCH domain Ysc84 PF04366.12 KOS22903.1 - 1.7e-51 173.3 1.3 3.1e-51 172.4 1.3 1.4 1 1 0 1 1 1 1 Las17-binding protein actin regulator FSH1 PF03959.13 KOS22904.1 - 1.9e-28 99.6 0.0 2.4e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 KOS22904.1 - 0.093 12.5 0.2 1.3 8.8 0.1 2.3 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase 7tm_2 PF00002.24 KOS22905.1 - 2.1e-10 40.3 2.9 3.6e-10 39.5 2.9 1.3 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) Git3 PF11710.8 KOS22905.1 - 0.0018 18.1 1.5 0.0018 18.1 1.5 1.5 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 7tm_1 PF00001.21 KOS22905.1 - 0.02 14.2 1.7 0.07 12.4 0.8 1.9 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) DUF4131 PF13567.6 KOS22905.1 - 1.1 8.9 3.7 2.6 7.7 0.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) C2 PF00168.30 KOS22906.1 - 1.2e-10 41.6 0.0 2.1e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 C2 domain SAICAR_synt PF01259.18 KOS22907.1 - 2.9e-93 312.1 0.0 3.7e-93 311.8 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase TFIIF_alpha PF05793.12 KOS22908.1 - 5.9 5.4 4.7 7.2 5.1 4.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) p450 PF00067.22 KOS22909.1 - 1.5e-37 129.4 0.0 2e-37 129.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Aminotran_1_2 PF00155.21 KOS22910.1 - 3.9e-31 108.5 0.0 5.1e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II AMP-binding PF00501.28 KOS22912.1 - 1.1e-91 307.6 1.4 8.3e-66 222.3 0.0 2.6 3 0 0 3 3 3 2 AMP-binding enzyme Condensation PF00668.20 KOS22912.1 - 4.4e-47 160.8 0.0 1.3e-29 103.3 0.0 3.0 3 0 0 3 3 3 2 Condensation domain PP-binding PF00550.25 KOS22912.1 - 2.2e-22 79.2 1.8 3e-08 33.9 0.1 3.8 3 0 0 3 3 3 3 Phosphopantetheine attachment site AMP-binding_C PF13193.6 KOS22912.1 - 0.11 13.5 0.0 0.33 12.0 0.0 1.9 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain GST_N_3 PF13417.6 KOS22914.1 - 1.3e-09 38.3 0.0 2.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOS22914.1 - 1.7e-08 34.6 0.0 3e-08 33.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 KOS22914.1 - 2.6e-07 30.7 0.0 4.9e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOS22914.1 - 1.2e-05 25.4 0.0 2.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 KOS22914.1 - 0.00049 20.4 0.0 0.0009 19.5 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Tom37 PF10568.9 KOS22914.1 - 0.0043 17.3 0.0 0.0062 16.8 0.0 1.2 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein GST_C_2 PF13410.6 KOS22914.1 - 0.013 15.6 0.0 0.03 14.3 0.0 1.7 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Epimerase PF01370.21 KOS22915.1 - 6.6e-18 65.0 0.0 9.9e-18 64.5 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS22915.1 - 2.3e-17 63.4 0.5 8.2e-13 48.4 0.1 3.0 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KOS22915.1 - 1e-09 38.0 0.1 5.2e-08 32.4 0.0 2.7 2 1 1 3 3 3 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 KOS22915.1 - 1.1e-09 37.9 0.0 1.4e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein RmlD_sub_bind PF04321.17 KOS22915.1 - 1.9e-07 30.5 0.0 5.5e-07 29.0 0.0 1.5 1 1 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 KOS22915.1 - 7.5e-06 25.1 0.0 1.5e-05 24.1 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family adh_short PF00106.25 KOS22915.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase KR PF08659.10 KOS22915.1 - 0.14 12.1 0.1 18 5.2 0.0 2.4 2 0 0 2 2 2 0 KR domain Inositol_P PF00459.25 KOS22916.1 - 1.2e-33 116.8 1.5 6.2e-32 111.2 1.5 2.7 1 1 0 1 1 1 1 Inositol monophosphatase family TetR_C_14 PF17754.1 KOS22916.1 - 0.028 14.3 0.6 0.06 13.3 0.3 1.7 2 0 0 2 2 2 0 MftR C-terminal domain Rep-A_N PF04057.12 KOS22917.1 - 0.036 14.1 0.0 0.068 13.2 0.0 1.5 1 0 0 1 1 1 0 Replication factor-A protein 1, N-terminal domain F-box-like PF12937.7 KOS22918.1 - 2.4e-05 24.1 0.5 6.5e-05 22.7 0.5 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS22918.1 - 0.069 13.1 0.3 0.16 11.9 0.3 1.5 1 0 0 1 1 1 0 F-box domain MFS_1 PF07690.16 KOS22919.1 - 3.9e-09 35.9 43.3 8.7e-07 28.2 9.7 3.1 2 1 0 3 3 3 2 Major Facilitator Superfamily Nodulin-like PF06813.13 KOS22919.1 - 9.6e-07 28.5 16.1 0.0043 16.6 2.1 3.2 3 0 0 3 3 3 2 Nodulin-like DUF5316 PF17247.2 KOS22919.1 - 0.081 12.9 1.3 1.6 8.8 0.0 3.2 2 0 0 2 2 2 0 Family of unknown function (DUF5316) IncD PF17628.2 KOS22919.1 - 4.6 7.0 9.2 0.77 9.5 0.3 2.9 2 1 0 2 2 2 0 Inclusion membrane protein D ERG4_ERG24 PF01222.17 KOS22920.1 - 2.5e-86 290.1 0.3 3.1e-86 289.8 0.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOS22920.1 - 1.8e-06 27.6 0.1 7.8e-06 25.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 KOS22920.1 - 0.034 14.6 0.0 0.073 13.5 0.0 1.5 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family CAP_N PF01213.19 KOS22920.1 - 7.4 6.0 9.8 11 5.4 9.8 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mre11_DNA_bind PF04152.14 KOS22921.1 - 2.6e-52 177.5 0.1 8.2e-52 175.9 0.1 1.9 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 KOS22921.1 - 9.3e-15 55.7 1.4 1.3e-14 55.2 0.9 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 KOS22921.1 - 0.001 19.3 0.9 0.021 15.0 0.9 2.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Roughex PF06020.11 KOS22921.1 - 9.2 5.3 12.6 18 4.3 12.6 1.4 1 0 0 1 1 1 0 Drosophila roughex protein CN_hydrolase PF00795.22 KOS22922.1 - 8e-36 123.7 0.2 8.8e-28 97.4 0.1 3.3 2 2 0 2 2 2 2 Carbon-nitrogen hydrolase WLM PF08325.10 KOS22923.1 - 8.6e-49 166.2 0.8 1.7e-48 165.2 0.0 1.7 2 0 0 2 2 2 1 WLM domain DUF45 PF01863.17 KOS22923.1 - 0.0036 17.4 2.8 0.0041 17.2 0.8 1.9 2 0 0 2 2 2 1 Protein of unknown function DUF45 SprT-like PF10263.9 KOS22923.1 - 0.016 15.1 0.1 0.026 14.4 0.1 1.4 1 0 0 1 1 1 0 SprT-like family Reprolysin_5 PF13688.6 KOS22923.1 - 0.021 15.0 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 ER_lumen_recept PF00810.18 KOS22924.1 - 5.2e-54 183.1 3.9 5.2e-54 183.1 3.9 1.4 2 0 0 2 2 2 1 ER lumen protein retaining receptor PQ-loop PF04193.14 KOS22924.1 - 0.018 14.8 6.2 0.77 9.6 0.1 3.6 2 1 1 3 3 3 0 PQ loop repeat Mito_carr PF00153.27 KOS22925.1 - 6.1e-52 173.5 5.1 1.8e-17 63.1 0.2 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 KOS22925.1 - 0.033 13.4 0.1 1.3 8.1 0.0 2.5 2 1 0 3 3 3 0 Gammaproteobacterial serine protease PMSI1 PF15322.6 KOS22925.1 - 0.064 12.7 2.2 0.096 12.1 2.2 1.2 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative DUF3439 PF11921.8 KOS22925.1 - 0.16 11.9 14.0 0.29 11.1 14.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 KOS22925.1 - 0.18 11.8 15.8 0.34 10.9 15.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 KOS22925.1 - 1.3 7.0 5.6 1.6 6.6 5.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 KOS22925.1 - 1.9 6.6 16.0 2.7 6.1 16.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 KOS22925.1 - 3.8 8.0 8.1 7.9 6.9 8.1 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Sporozoite_P67 PF05642.11 KOS22925.1 - 9.1 4.2 6.5 12 3.8 6.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nuf2 PF03800.14 KOS22927.1 - 3.5e-41 140.6 1.1 4.8e-41 140.1 0.0 1.8 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 KOS22927.1 - 6.7e-36 122.9 18.4 6.7e-36 122.9 18.4 4.6 4 1 2 6 6 6 2 Designed helical repeat protein 10 domain Ndc1_Nup PF09531.10 KOS22927.1 - 0.19 10.4 0.8 0.34 9.5 0.1 1.7 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Thioredoxin PF00085.20 KOS22928.1 - 7.7e-26 90.1 0.0 9.9e-26 89.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 KOS22928.1 - 4.8e-07 30.2 0.1 1.6e-06 28.5 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 KOS22928.1 - 8.8e-06 26.0 0.0 2.2e-05 24.7 0.0 1.6 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin_9 PF14595.6 KOS22928.1 - 4.1e-05 23.3 0.0 4.6e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 KOS22928.1 - 4.3e-05 23.0 0.0 5.1e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 KOS22928.1 - 0.00015 21.7 0.0 0.00017 21.5 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein Glutaredoxin PF00462.24 KOS22928.1 - 0.0007 19.8 0.0 0.0011 19.1 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 KOS22928.1 - 0.0016 18.6 0.0 0.0025 18.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like HyaE PF07449.11 KOS22928.1 - 0.014 15.3 0.0 0.028 14.4 0.0 1.5 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE Redoxin PF08534.10 KOS22928.1 - 0.034 13.9 0.1 0.076 12.7 0.1 1.6 1 1 0 1 1 1 0 Redoxin Thioredoxin_5 PF13743.6 KOS22928.1 - 0.037 13.7 0.0 1.2 8.7 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Methyltransf_PK PF05891.12 KOS22930.1 - 3.3e-62 209.9 0.0 3.9e-62 209.6 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 KOS22930.1 - 0.00063 20.4 0.0 0.001 19.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS22930.1 - 0.071 13.8 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_M50B PF13398.6 KOS22931.1 - 2.5e-59 200.3 20.1 3e-59 200.0 20.1 1.0 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.22 KOS22931.1 - 0.026 13.8 0.2 0.062 12.6 0.2 1.6 1 0 0 1 1 1 0 Peptidase family M50 MLANA PF14991.6 KOS22931.1 - 3.9 7.8 6.6 0.89 9.9 0.9 2.2 1 1 1 2 2 2 0 Protein melan-A YlaC PF10777.9 KOS22931.1 - 6.6 6.6 6.3 0.5 10.2 0.5 1.9 2 0 0 2 2 2 0 Inner membrane protein YlaC Glyco_hydro_18 PF00704.28 KOS22932.1 - 1.5e-25 90.6 1.1 1.2e-24 87.6 1.1 1.9 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Peptidase_M4 PF01447.18 KOS22932.1 - 0.54 10.7 2.4 0.86 10.1 0.2 2.2 3 0 0 3 3 3 0 Thermolysin metallopeptidase, catalytic domain Fip1 PF05182.13 KOS22933.1 - 8.5e-20 70.0 0.5 1.5e-19 69.2 0.5 1.4 1 0 0 1 1 1 1 Fip1 motif FAM117 PF15388.6 KOS22933.1 - 0.25 10.7 3.3 0.33 10.3 3.3 1.1 1 0 0 1 1 1 0 Protein Family FAM117 Fzo_mitofusin PF04799.13 KOS22934.1 - 0.0071 15.9 1.1 0.065 12.8 0.0 2.5 2 1 0 2 2 2 1 fzo-like conserved region Spc7 PF08317.11 KOS22934.1 - 0.019 13.9 0.7 0.67 8.8 0.0 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Tup_N PF08581.10 KOS22934.1 - 0.026 14.8 3.0 0.14 12.5 0.4 2.5 3 0 0 3 3 3 0 Tup N-terminal Vps53_N PF04100.12 KOS22934.1 - 0.032 13.2 0.5 0.032 13.2 0.5 1.6 2 0 0 2 2 2 0 Vps53-like, N-terminal THDPS_N_2 PF14805.6 KOS22934.1 - 0.043 14.0 0.1 3.4 8.0 0.0 2.6 2 1 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DUF1664 PF07889.12 KOS22934.1 - 0.063 13.3 3.0 0.87 9.6 0.4 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF1664) RmuC PF02646.16 KOS22934.1 - 0.088 11.9 1.0 1.9 7.5 0.0 2.6 2 1 1 3 3 3 0 RmuC family Jnk-SapK_ap_N PF09744.9 KOS22934.1 - 0.11 12.8 0.7 3.3 7.9 0.1 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4455 PF14643.6 KOS22934.1 - 0.11 11.1 1.4 6.2 5.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4455) FliJ PF02050.16 KOS22934.1 - 0.17 12.1 4.5 3.8 7.8 0.3 2.8 2 1 0 2 2 2 0 Flagellar FliJ protein zf-C4H2 PF10146.9 KOS22934.1 - 0.17 12.2 1.9 1.3 9.3 0.2 2.2 2 1 0 2 2 2 0 Zinc finger-containing protein DUF5082 PF16888.5 KOS22934.1 - 0.66 10.3 5.0 11 6.3 0.1 3.5 2 2 1 4 4 4 0 Domain of unknown function (DUF5082) ING PF12998.7 KOS22934.1 - 0.66 10.6 4.1 1.9 9.1 0.8 2.2 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF4763 PF15960.5 KOS22934.1 - 0.68 9.2 2.9 2.2 7.6 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) DUF2203 PF09969.9 KOS22934.1 - 0.8 10.4 3.8 4.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 KOS22934.1 - 2.8 8.6 5.4 13 6.5 0.3 3.6 2 1 1 3 3 3 0 SlyX RNA_pol_3_Rpc31 PF11705.8 KOS22935.1 - 1.3e-60 205.5 0.9 2.3e-60 204.7 0.9 1.4 1 1 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Sec7 PF01369.20 KOS22937.1 - 2.4e-70 235.9 0.8 2.4e-70 235.9 0.8 2.5 3 0 0 3 3 3 1 Sec7 domain Sec7_N PF12783.7 KOS22937.1 - 4.4e-40 137.2 3.6 4.4e-40 137.2 3.6 3.4 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 KOS22937.1 - 1.3e-33 114.6 10.8 5.6e-32 109.4 0.1 5.3 6 0 0 6 6 6 2 Domain of unknown function (DUF1981) DCB PF16213.5 KOS22937.1 - 9.4e-23 80.8 4.8 3.4e-22 79.0 0.7 3.3 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 RIH_assoc PF08454.11 KOS22937.1 - 0.068 13.0 0.2 0.75 9.7 0.1 2.9 2 0 0 2 2 2 0 RyR and IP3R Homology associated 2-oxoacid_dh PF00198.23 KOS22938.1 - 2.3e-76 256.3 0.1 2.9e-76 256.0 0.1 1.1 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 KOS22938.1 - 4.4e-19 68.1 0.8 8.8e-19 67.1 0.8 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 KOS22938.1 - 8.7e-14 51.6 0.8 2.3e-13 50.2 0.8 1.8 1 0 0 1 1 1 1 e3 binding domain DUF3614 PF12267.8 KOS22938.1 - 0.0038 17.7 0.3 0.011 16.2 0.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3614) Gar1 PF04410.14 KOS22940.1 - 1.7e-47 161.0 0.1 5.1e-47 159.5 0.1 1.8 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region Sld5 PF05916.11 KOS22941.1 - 2e-30 105.4 0.0 3.2e-30 104.8 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein Yos1 PF08571.10 KOS22942.1 - 8.5e-32 109.3 0.4 9.5e-32 109.1 0.4 1.0 1 0 0 1 1 1 1 Yos1-like Glyco_transf_22 PF03901.17 KOS22943.1 - 2.3e-84 284.1 19.5 2.7e-84 283.8 19.5 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Cpn60_TCP1 PF00118.24 KOS22944.1 - 1.4e-152 508.8 14.8 1.6e-152 508.6 14.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rieske PF00355.26 KOS22945.1 - 5.6e-11 42.2 0.0 9.5e-11 41.5 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 KOS22945.1 - 1.1e-10 41.8 0.3 3.2e-10 40.3 0.3 1.9 1 0 0 1 1 1 1 Ubiquinol cytochrome reductase transmembrane region Acetyltransf_7 PF13508.7 KOS22946.1 - 0.0011 19.3 0.0 0.0025 18.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS22946.1 - 0.0017 18.4 0.1 0.0049 16.9 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS22946.1 - 0.059 13.6 0.0 0.45 10.8 0.0 2.2 2 0 0 2 2 2 0 Acetyltransferase (GNAT) family ProRS-C_1 PF09180.11 KOS22947.1 - 1e-23 83.3 0.0 2.4e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal tRNA-synt_2b PF00587.25 KOS22947.1 - 3.4e-21 76.0 0.0 5.7e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 KOS22947.1 - 1.2e-16 60.6 0.0 6e-16 58.4 0.0 2.2 2 0 0 2 2 2 1 Anticodon binding domain MT0933_antitox PF14013.6 KOS22947.1 - 8.5 6.8 9.2 6.8 7.1 4.8 2.6 2 0 0 2 2 2 0 MT0933-like antitoxin protein DUF3981 PF13139.6 KOS22948.1 - 0.11 12.8 0.5 0.24 11.8 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) Methyltransf_11 PF08241.12 KOS22949.1 - 8e-10 39.2 0.1 1.5e-09 38.4 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS22949.1 - 3.6e-09 36.6 0.0 5e-09 36.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS22949.1 - 4.3e-09 36.4 0.0 6.5e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS22949.1 - 2.8e-08 34.4 0.2 7.2e-08 33.0 0.2 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS22949.1 - 3.8e-05 24.4 0.0 6e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 KOS22949.1 - 0.00036 20.3 0.0 0.00053 19.8 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase adh_short_C2 PF13561.6 KOS22949.1 - 0.007 15.9 0.1 0.011 15.4 0.1 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase MTS PF05175.14 KOS22949.1 - 0.089 12.3 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain Ubie_methyltran PF01209.18 KOS22949.1 - 0.096 12.0 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family DUF5127 PF17168.4 KOS22950.1 - 8.2e-84 280.9 6.4 1.2e-83 280.3 6.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5127) DUF4965 PF16335.5 KOS22950.1 - 8.1e-69 230.7 0.0 1.4e-68 230.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4965) DUF1793 PF08760.11 KOS22950.1 - 3.3e-58 196.8 2.4 1.5e-57 194.7 0.5 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF1793) Glyco_hydr_116N PF12215.8 KOS22950.1 - 0.00037 20.1 0.2 0.0015 18.1 0.1 1.9 2 0 0 2 2 2 1 beta-glucosidase 2, glycosyl-hydrolase family 116 N-term MFS_1 PF07690.16 KOS22951.1 - 6.5e-27 94.4 34.9 6.5e-27 94.4 34.9 1.5 2 0 0 2 2 2 1 Major Facilitator Superfamily UNC-93 PF05978.16 KOS22951.1 - 0.33 10.7 3.8 0.39 10.4 2.4 1.8 1 1 1 2 2 2 0 Ion channel regulatory protein UNC-93 ATG22 PF11700.8 KOS22951.1 - 0.38 9.3 8.1 0.14 10.8 4.2 2.4 1 1 0 1 1 1 0 Vacuole effluxer Atg22 like DUF1616 PF07760.11 KOS22951.1 - 2.1 7.6 5.4 8.1 5.7 5.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) YCII PF03795.14 KOS22952.1 - 5.4e-08 33.1 0.0 6.3e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain DUF2408 PF10303.9 KOS22953.1 - 3.1e-42 144.3 1.3 2.3e-25 89.7 0.0 4.8 2 2 3 5 5 5 3 Protein of unknown function (DUF2408) CARD PF00619.21 KOS22953.1 - 0.095 12.7 0.4 0.29 11.2 0.4 1.9 1 1 0 1 1 1 0 Caspase recruitment domain TelA PF05816.11 KOS22953.1 - 0.1 11.7 0.2 0.82 8.7 0.0 2.0 1 1 1 2 2 2 0 Toxic anion resistance protein (TelA) DUF1539 PF07560.11 KOS22953.1 - 0.11 12.6 0.7 0.28 11.3 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) UBX PF00789.20 KOS22954.1 - 2.1e-05 24.6 0.3 8.1e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 UBX domain UBA PF00627.31 KOS22954.1 - 0.011 15.6 0.0 0.04 13.8 0.0 2.0 1 0 0 1 1 1 0 UBA/TS-N domain zf-C2H2 PF00096.26 KOS22954.1 - 0.033 14.6 0.2 0.057 13.9 0.2 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type TFIIS_C PF01096.18 KOS22954.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) zf-LYAR PF08790.11 KOS22954.1 - 0.86 9.6 0.1 0.86 9.6 0.1 2.1 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger SOBP PF15279.6 KOS22954.1 - 1 9.9 5.5 1.2 9.6 5.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein ArfGap PF01412.18 KOS22954.1 - 2.7 8.1 7.2 0.33 11.1 1.5 2.2 1 1 2 3 3 3 0 Putative GTPase activating protein for Arf zf-C2H2_3rep PF18868.1 KOS22954.1 - 3.5 8.3 5.5 1.1 9.9 0.7 2.2 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats DUF4776 PF16003.5 KOS22954.1 - 4.5 6.2 21.3 6.1 5.7 21.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Hamartin PF04388.12 KOS22954.1 - 4.9 5.7 14.2 6.4 5.3 14.2 1.3 1 0 0 1 1 1 0 Hamartin protein RskA PF10099.9 KOS22954.1 - 5.1 7.3 14.0 0.082 13.2 5.8 2.1 2 0 0 2 2 2 0 Anti-sigma-K factor rskA CAP_GLY PF01302.25 KOS22955.1 - 5.1e-19 68.1 3.7 8.3e-19 67.4 3.7 1.3 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 KOS22955.1 - 2.2e-17 63.3 0.0 3.1e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like domain ubiquitin PF00240.23 KOS22955.1 - 0.015 15.0 0.0 0.028 14.1 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin family Myb_DNA-binding PF00249.31 KOS22956.1 - 6.6e-14 51.8 4.3 1.2e-10 41.4 0.0 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS22956.1 - 1.8e-05 24.9 3.8 0.0092 16.2 0.0 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Peroxin-3 PF04882.12 KOS22956.1 - 7.1 5.5 8.3 12 4.8 8.3 1.3 1 0 0 1 1 1 0 Peroxin-3 CITED PF04487.12 KOS22956.1 - 7.7 6.5 9.8 12 5.8 9.8 1.4 1 1 0 1 1 1 0 CITED ATP-synt_Eps PF04627.13 KOS22957.1 - 8.4e-23 80.1 2.8 1.3e-22 79.5 2.8 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain SRP-alpha_N PF04086.13 KOS22958.1 - 0.91 9.4 16.0 1.8 8.5 16.0 1.5 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 KOS22958.1 - 0.94 7.7 10.1 1.2 7.3 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 KOS22958.1 - 5 5.8 8.9 7.5 5.2 8.9 1.2 1 0 0 1 1 1 0 Presenilin Mito_carr PF00153.27 KOS22959.1 - 4.8e-52 173.8 5.6 9e-17 60.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Mak10 PF04112.13 KOS22960.1 - 2.9e-50 170.1 0.0 4.8e-50 169.4 0.0 1.4 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase YwcE PF17368.2 KOS22961.1 - 0.0078 16.9 4.0 0.011 16.4 3.8 1.4 1 1 0 1 1 1 1 Spore morphogenesis and germination YwcE DUF3671 PF12420.8 KOS22961.1 - 0.074 13.1 0.6 0.12 12.4 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function DUF3959 PF13105.6 KOS22961.1 - 0.67 9.4 4.0 0.8 9.2 4.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) zf-RING_2 PF13639.6 KOS22962.1 - 2.7e-12 46.8 4.9 4.5e-12 46.1 4.9 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 KOS22962.1 - 1.1e-10 41.1 2.2 2.1e-10 40.1 2.2 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 KOS22962.1 - 6.9e-08 32.2 4.7 1.1e-07 31.6 4.7 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 KOS22962.1 - 2.1e-07 30.7 3.9 3.7e-07 29.9 3.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 KOS22962.1 - 1.9e-06 28.0 5.6 5.4e-06 26.6 5.6 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 KOS22962.1 - 1.3e-05 25.0 3.2 2.3e-05 24.2 3.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 KOS22962.1 - 1.8e-05 24.6 2.0 3.1e-05 23.8 2.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 KOS22962.1 - 0.0014 18.6 0.4 0.0027 17.7 0.4 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 KOS22962.1 - 0.002 18.0 1.5 0.0031 17.3 1.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 KOS22962.1 - 0.0072 16.3 5.8 0.015 15.3 5.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_4 PF14570.6 KOS22962.1 - 0.043 13.6 3.2 0.075 12.8 3.2 1.3 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-HC5HC2H_2 PF13832.6 KOS22962.1 - 0.069 13.3 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain PHD PF00628.29 KOS22962.1 - 0.55 10.2 2.5 1 9.3 2.5 1.5 1 0 0 1 1 1 0 PHD-finger FANCL_C PF11793.8 KOS22962.1 - 0.74 10.0 3.2 6.1 7.1 3.2 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain Menin PF05053.13 KOS22962.1 - 3.1 6.0 8.5 4.5 5.5 8.5 1.1 1 0 0 1 1 1 0 Menin Glyco_hydro_cc PF11790.8 KOS22963.1 - 3.3e-52 177.4 0.5 4.2e-52 177.1 0.5 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase catalytic core Mur_ligase_M PF08245.12 KOS22965.1 - 7.8e-08 32.5 0.1 2.3e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Mur ligase middle domain ExsD PF16806.5 KOS22965.1 - 0.15 12.0 0.1 0.25 11.2 0.1 1.2 1 0 0 1 1 1 0 Antiactivator protein ExsD Complex1_LYR PF05347.15 KOS22966.1 - 5.6e-07 29.5 0.2 1.3e-06 28.4 0.2 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 KOS22966.1 - 0.017 15.9 1.0 0.032 15.0 1.0 1.7 1 1 0 1 1 1 0 Complex1_LYR-like ChaB PF06150.12 KOS22966.1 - 0.027 15.0 0.2 1.1 9.9 0.1 2.7 2 0 0 2 2 2 0 ChaB Thymidylat_synt PF00303.19 KOS22967.1 - 1.7e-98 329.0 0.0 5.3e-97 324.1 0.0 2.0 1 1 0 1 1 1 1 Thymidylate synthase MFS_1 PF07690.16 KOS22968.1 - 1.7e-32 112.8 25.3 1.7e-32 112.8 25.3 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily ThrE PF06738.12 KOS22968.1 - 0.15 11.4 5.9 0.15 11.4 2.3 2.2 2 0 0 2 2 2 0 Putative threonine/serine exporter DUF1772 PF08592.11 KOS22968.1 - 8.1 6.8 12.5 1e+02 3.2 0.1 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF1772) Amidoligase_2 PF12224.8 KOS22969.1 - 9.8e-10 38.5 0.1 5.3e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 Putative amidoligase enzyme MFS_1 PF07690.16 KOS22970.1 - 6.1e-09 35.3 24.8 7.2e-09 35.0 24.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Acetyltransf_1 PF00583.25 KOS22971.1 - 9.6e-17 61.3 0.0 1.3e-16 60.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS22971.1 - 2.8e-09 37.0 0.0 4.3e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS22971.1 - 2.5e-08 34.2 0.0 4e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS22971.1 - 3.1e-08 33.5 0.0 5.4e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 KOS22971.1 - 3.2e-05 24.6 0.0 5.5e-05 23.9 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 KOS22971.1 - 0.0014 18.8 0.0 0.15 12.2 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 KOS22971.1 - 0.018 15.1 0.0 0.047 13.8 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase AltA1 PF16541.5 KOS22972.1 - 4.3e-20 72.6 1.8 4.3e-20 72.6 1.8 1.6 2 0 0 2 2 2 1 Alternaria alternata allergen 1 AA_permease_2 PF13520.6 KOS22973.1 - 1.6e-85 287.5 31.9 2e-85 287.2 31.9 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 KOS22973.1 - 2.6e-17 62.6 29.5 4e-17 62.0 29.5 1.3 1 0 0 1 1 1 1 Amino acid permease ATP-synt_J PF04911.12 KOS22973.1 - 0.28 10.8 2.3 0.28 10.8 0.2 2.2 2 0 0 2 2 2 0 ATP synthase j chain RSS_P20 PF11757.8 KOS22975.1 - 0.16 12.4 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain Glyco_hydro_92 PF07971.12 KOS22976.1 - 1.7e-140 469.0 0.0 2.1e-140 468.7 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 KOS22976.1 - 1e-55 189.2 0.0 1.4e-55 188.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Gln-synt_N PF03951.19 KOS22976.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Glutamine synthetase, beta-Grasp domain Glyco_hydro_16 PF00722.21 KOS22977.1 - 6.3e-43 146.3 1.0 9.9e-43 145.7 1.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 16 Sec63 PF02889.16 KOS22978.1 - 4.3e-13 49.0 0.0 5.6e-13 48.6 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain HHH_5 PF14520.6 KOS22978.1 - 0.00048 20.7 0.0 0.00096 19.7 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 KOS22978.1 - 0.00062 20.0 0.0 0.0017 18.6 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4332) DNA_pol_lambd_f PF10391.9 KOS22978.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda Trypan_PARP PF05887.11 KOS22978.1 - 0.13 12.2 3.8 0.29 11.1 3.8 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SPESP1 PF15754.5 KOS22978.1 - 0.2 10.8 0.1 0.27 10.4 0.1 1.1 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 Band_7 PF01145.25 KOS22980.1 - 2.3e-28 99.4 0.7 2.3e-28 99.4 0.7 1.8 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_C PF16200.5 KOS22980.1 - 2.4e-21 75.6 0.3 2.4e-21 75.6 0.3 2.2 2 0 0 2 2 2 1 C-terminal region of band_7 Pox_A11 PF05061.13 KOS22980.1 - 0.019 14.3 0.1 0.03 13.6 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A11 Protein UQ_con PF00179.26 KOS22981.1 - 1.4e-16 60.4 0.0 1.5e-16 60.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 KOS22981.1 - 0.015 15.5 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 RWD domain Flavoprotein PF02441.19 KOS22983.1 - 8.8e-15 54.8 0.0 1.7e-14 53.8 0.0 1.4 1 0 0 1 1 1 1 Flavoprotein Dimer_Tnp_hAT PF05699.14 KOS22983.1 - 0.67 9.8 3.6 20 5.0 0.0 4.4 6 0 0 6 6 6 0 hAT family C-terminal dimerisation region UQ_con PF00179.26 KOS22984.1 - 1.7e-35 121.7 0.1 2.2e-35 121.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF572 PF04502.13 KOS22985.1 - 6.3e-56 190.4 0.0 7.2e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DLH PF01738.18 KOS22986.1 - 2.4e-10 40.4 0.0 2.7e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Glyco_hydro_20 PF00728.22 KOS22987.1 - 5e-101 338.6 0.3 6.2e-101 338.3 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 KOS22987.1 - 8.2e-27 94.5 0.0 1.8e-26 93.4 0.0 1.6 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 KOS22987.1 - 9.1e-05 23.2 0.0 0.00022 22.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, domain 2 Pro_isomerase PF00160.21 KOS22988.1 - 3.8e-32 111.7 0.0 5.9e-32 111.1 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 KOS22988.1 - 6e-15 54.8 0.0 1.1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FTA2 PF13095.6 KOS22989.1 - 0.0048 16.5 0.1 0.0057 16.3 0.1 1.0 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 PNISR PF15996.5 KOS22989.1 - 0.029 14.7 0.9 0.045 14.0 0.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Activator_LAG-3 PF11498.8 KOS22989.1 - 0.054 12.5 0.1 0.062 12.3 0.1 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 FliT PF05400.13 KOS22989.1 - 0.95 10.3 8.6 0.81 10.5 3.5 2.3 2 1 0 2 2 2 0 Flagellar protein FliT Asp_Glu_race PF01177.22 KOS22990.1 - 1e-06 28.8 0.1 0.016 15.0 0.0 2.2 2 0 0 2 2 2 2 Asp/Glu/Hydantoin racemase Vsr PF03852.15 KOS22990.1 - 0.081 12.8 0.0 95 3.0 0.0 3.3 3 0 0 3 3 3 0 DNA mismatch endonuclease Vsr Zn_clus PF00172.18 KOS22991.1 - 9.3e-09 35.3 7.0 1.4e-08 34.7 7.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain TFIIA PF03153.13 KOS22991.1 - 0.01 15.9 7.4 0.01 15.9 7.4 1.5 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4770 PF15994.5 KOS22991.1 - 0.038 14.2 3.1 2.4 8.3 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SPX PF03105.19 KOS22991.1 - 0.43 10.4 9.0 0.67 9.8 9.0 1.2 1 0 0 1 1 1 0 SPX domain Spt20 PF12090.8 KOS22991.1 - 0.86 9.2 16.3 1.5 8.4 16.3 1.3 1 0 0 1 1 1 0 Spt20 family baeRF_family10 PF18854.1 KOS22991.1 - 5.6 7.2 6.4 10 6.4 6.4 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 Actin PF00022.19 KOS22992.1 - 9.9e-112 373.5 0.0 6.2e-111 370.9 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 KOS22992.1 - 0.0012 17.8 0.0 0.0082 15.0 0.0 2.0 1 1 0 1 1 1 1 MreB/Mbl protein Arf PF00025.21 KOS22993.1 - 3.7e-74 247.9 0.2 4.3e-74 247.7 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 KOS22993.1 - 1.1e-13 51.4 0.0 1.6e-13 50.9 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 KOS22993.1 - 4.4e-13 49.1 0.0 5e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 KOS22993.1 - 6.7e-12 45.2 1.6 8e-08 31.8 0.2 2.5 1 1 1 2 2 2 2 G-protein alpha subunit SRPRB PF09439.10 KOS22993.1 - 1.6e-10 40.7 0.0 2e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 KOS22993.1 - 1.7e-09 37.4 0.1 2.3e-09 36.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 KOS22993.1 - 0.0006 19.9 0.0 0.00082 19.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 KOS22993.1 - 0.056 12.7 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SpoOE-like PF09388.10 KOS22993.1 - 0.077 12.9 0.6 0.14 12.1 0.6 1.4 1 0 0 1 1 1 0 Spo0E like sporulation regulatory protein PPL4 PF18188.1 KOS22993.1 - 0.12 12.4 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Prim-pol 4 Methyltrn_RNA_3 PF02598.17 KOS22993.1 - 0.12 11.9 0.0 0.16 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methyltransferase HAD_2 PF13419.6 KOS22994.1 - 8.2e-17 61.9 0.0 1.8e-16 60.7 0.0 1.6 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS22994.1 - 4.7e-09 36.9 0.0 2.2e-07 31.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS22994.1 - 0.00088 19.3 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like TENA_THI-4 PF03070.16 KOS22995.1 - 0.017 15.0 0.2 1.6 8.5 0.0 2.4 2 0 0 2 2 2 0 TENA/THI-4/PQQC family Fungal_trans_2 PF11951.8 KOS22996.1 - 3.1e-06 26.2 0.0 4.2e-06 25.8 0.0 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain TPR_12 PF13424.6 KOS22997.1 - 1.8e-05 24.9 3.9 8e-05 22.9 3.9 2.1 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOS22997.1 - 2.6e-05 24.0 6.9 0.063 13.4 1.5 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 KOS22997.1 - 0.00051 19.8 6.6 0.087 12.7 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 KOS22997.1 - 0.0099 16.6 1.0 0.0099 16.6 1.0 3.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS22997.1 - 0.045 13.8 4.6 2 8.6 0.1 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOS22997.1 - 0.18 11.7 1.6 13 5.8 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 KOS22997.1 - 0.27 11.8 6.2 0.063 13.8 1.8 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOS22997.1 - 0.75 10.6 4.3 82 4.2 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 KOS22997.1 - 4.1 8.2 16.1 0.23 12.1 6.7 3.1 2 2 1 3 3 3 0 Tetratricopeptide repeat Pantoate_ligase PF02569.15 KOS22998.1 - 4.2e-96 321.3 0.0 4.9e-96 321.0 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Robl_LC7 PF03259.17 KOS22998.1 - 0.25 11.2 0.8 1.4 8.8 0.1 2.4 3 0 0 3 3 3 0 Roadblock/LC7 domain WD40 PF00400.32 KOS22999.1 - 5.3e-05 23.9 0.1 0.0027 18.5 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat UPF0086 PF01868.16 KOS23000.1 - 2.8e-28 97.7 0.2 5.1e-28 96.8 0.1 1.5 2 0 0 2 2 2 1 Domain of unknown function UPF0086 Acyltransferase PF01553.21 KOS23001.1 - 2.5e-17 62.8 0.0 4.8e-17 61.8 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase DUF2076 PF09849.9 KOS23002.1 - 0.00021 21.5 19.8 0.00028 21.0 19.8 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) Zip PF02535.22 KOS23002.1 - 0.01 15.1 0.8 0.016 14.4 0.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Sugar_tr PF00083.24 KOS23003.1 - 2.2e-42 145.5 21.1 5.6e-42 144.2 21.1 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS23003.1 - 3.9e-36 124.7 43.5 1.7e-32 112.7 25.8 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS23003.1 - 0.0024 16.8 2.4 0.0024 16.8 2.4 2.4 1 1 1 2 2 2 1 MFS_1 like family Flavi_NS4A PF01350.17 KOS23003.1 - 0.057 13.3 0.3 0.18 11.8 0.3 1.8 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4A SP24 PF16504.5 KOS23003.1 - 0.087 12.9 0.2 0.25 11.4 0.2 1.8 1 0 0 1 1 1 0 Putative virion membrane protein of plant and insect virus Ank_2 PF12796.7 KOS23004.1 - 1.5e-12 47.9 0.0 1.9e-06 28.3 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS23004.1 - 5.2e-12 46.0 0.2 0.002 18.6 0.0 3.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 KOS23004.1 - 9.3e-11 41.7 0.5 6.9e-05 23.1 0.4 4.2 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOS23004.1 - 1.4e-09 38.0 1.1 3e-05 24.2 0.3 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS23004.1 - 3.6e-09 36.1 0.1 0.026 15.0 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat UxaC PF02614.14 KOS23004.1 - 0.028 13.3 0.1 0.044 12.6 0.1 1.3 1 0 0 1 1 1 0 Glucuronate isomerase DHHA1 PF02272.19 KOS23004.1 - 8.4 6.8 8.0 1.4e+02 2.8 8.0 2.7 1 1 0 1 1 1 0 DHHA1 domain Actin PF00022.19 KOS23005.1 - 6.9e-119 397.1 0.0 3.2e-118 394.9 0.0 1.7 1 1 0 1 1 1 1 Actin DnaJ_C PF01556.18 KOS23006.1 - 3.7e-28 98.5 0.0 7.5e-28 97.5 0.0 1.5 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 KOS23006.1 - 7.5e-23 80.4 0.5 1.4e-22 79.6 0.5 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 KOS23006.1 - 3.2e-13 49.8 18.1 5.9e-13 49.0 18.1 1.5 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 KOS23006.1 - 0.00019 21.4 8.5 0.049 13.7 2.1 2.3 2 0 0 2 2 2 2 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 KOS23006.1 - 0.0046 16.6 3.2 0.05 13.3 0.3 2.3 1 1 1 2 2 2 1 Thaumarchaeal output domain 1 zf-C3HC4_3 PF13920.6 KOS23006.1 - 0.3 11.0 6.9 0.22 11.4 1.9 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 KOS23006.1 - 0.45 10.6 9.6 2.2 8.4 9.6 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_5 PF14634.6 KOS23006.1 - 1.8 8.6 9.2 1.7 8.7 2.1 2.4 2 0 0 2 2 2 0 zinc-RING finger domain Lar_restr_allev PF14354.6 KOS23006.1 - 4.8 7.6 10.1 2 8.8 1.3 3.0 1 1 2 3 3 3 0 Restriction alleviation protein Lar OB_NTP_bind PF07717.16 KOS23007.1 - 1.3e-21 76.7 0.0 2.9e-21 75.6 0.0 1.6 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 KOS23007.1 - 6.7e-19 68.2 0.1 6.7e-19 68.2 0.1 4.4 4 1 0 4 4 3 1 Helicase associated domain (HA2) Helicase_C PF00271.31 KOS23007.1 - 1.7e-14 54.1 0.0 5.2e-14 52.5 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 KOS23007.1 - 4.3e-05 23.4 0.1 9.3e-05 22.3 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 KOS23007.1 - 4.4e-05 23.8 2.4 4.6e-05 23.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 KOS23007.1 - 0.0011 18.8 0.0 0.003 17.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 KOS23007.1 - 0.0013 17.8 0.0 0.0037 16.4 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 KOS23007.1 - 0.022 14.4 1.6 0.053 13.2 0.2 2.3 2 1 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 KOS23007.1 - 0.03 14.7 0.1 0.075 13.4 0.1 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 KOS23007.1 - 0.074 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 KOS23007.1 - 0.38 11.3 0.0 0.38 11.3 0.0 2.4 2 1 0 2 2 1 0 ABC transporter ResIII PF04851.15 KOS23007.1 - 0.63 10.0 4.1 0.5 10.3 0.1 2.8 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit 2OG-FeII_Oxy_3 PF13640.6 KOS23008.1 - 1.4e-11 45.2 0.1 2.8e-11 44.2 0.1 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 KOS23008.1 - 0.0035 17.6 0.0 0.042 14.1 0.0 2.2 1 1 1 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Cu-oxidase_3 PF07732.15 KOS23009.1 - 1.3e-38 131.6 0.2 3.4e-38 130.3 0.2 1.7 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 KOS23009.1 - 1.6e-35 121.8 5.5 8e-25 87.2 0.8 3.5 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase PF00394.22 KOS23009.1 - 6.9e-17 62.0 0.0 7.4e-16 58.7 0.0 2.6 3 1 0 3 3 3 1 Multicopper oxidase DUF3602 PF12223.8 KOS23010.1 - 2.4e-12 47.3 12.7 9.4e-10 39.0 3.2 2.9 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) Glyco_hydro_76 PF03663.14 KOS23011.1 - 2e-151 504.7 8.2 2.3e-151 504.5 8.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 KOS23011.1 - 0.11 11.6 11.2 1.7 7.7 0.6 3.1 1 1 0 3 3 3 0 Glycosyl Hydrolase Family 88 COPIIcoated_ERV PF07970.12 KOS23012.1 - 1.3e-37 129.9 0.1 1.9e-37 129.2 0.1 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 KOS23012.1 - 8.1e-23 80.6 0.0 1.3e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PAP_PilO PF06864.12 KOS23013.1 - 0.032 13.1 0.4 0.052 12.4 0.4 1.2 1 0 0 1 1 1 0 Pilin accessory protein (PilO) Peptidase_M24 PF00557.24 KOS23014.1 - 2.6e-50 171.0 0.1 4.1e-50 170.4 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 KOS23014.1 - 1.3e-34 118.5 0.0 2.1e-34 117.9 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain Dfp1_Him1_M PF08630.10 KOS23015.1 - 3.3e-40 137.2 0.2 1.3e-39 135.3 0.0 2.2 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 KOS23015.1 - 2.4e-20 72.3 0.2 4e-20 71.6 0.2 1.4 1 0 0 1 1 1 1 DBF zinc finger Atrophin-1 PF03154.15 KOS23015.1 - 0.0002 19.8 18.2 0.0002 19.8 18.2 2.7 3 0 0 3 3 3 1 Atrophin-1 family PTCB-BRCT PF12738.7 KOS23015.1 - 0.074 13.0 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 twin BRCT domain APG12 PF04110.13 KOS23016.1 - 1.8e-25 89.1 0.0 2.7e-25 88.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Atg8 PF02991.16 KOS23016.1 - 0.0019 18.4 0.0 0.0023 18.1 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like Pantoate_transf PF02548.15 KOS23017.1 - 4.5e-106 354.0 0.1 5.2e-106 353.8 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 KOS23017.1 - 1.5e-09 37.7 0.1 2.5e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DUF4861 PF16153.5 KOS23017.1 - 0.014 14.4 0.0 0.02 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4861) DHHC PF01529.20 KOS23018.1 - 6.9e-29 100.6 2.6 6.9e-29 100.6 2.6 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase FAM195 PF14799.6 KOS23021.1 - 0.13 12.6 0.3 0.35 11.2 0.3 1.6 1 0 0 1 1 1 0 FAM195 family Aha1_N PF09229.11 KOS23022.1 - 4.4e-39 133.8 2.1 6.5e-39 133.3 2.1 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 KOS23022.1 - 3.3e-18 66.1 0.3 6.1e-18 65.2 0.3 1.5 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF4330 PF14221.6 KOS23022.1 - 0.065 13.5 0.4 0.14 12.4 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) HMG_CoA_synt_C PF08540.10 KOS23023.1 - 1.6e-102 342.9 0.7 2.2e-102 342.4 0.7 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 KOS23023.1 - 1.2e-83 279.2 0.1 2e-83 278.5 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal FAD_binding_4 PF01565.23 KOS23024.1 - 3.1e-14 52.9 0.0 4.7e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain DUF917 PF06032.12 KOS23024.1 - 0.057 12.3 0.0 0.093 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF917) DUF5585 PF17823.1 KOS23025.1 - 1.6 7.6 31.5 2 7.3 31.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5585) Acetyltransf_1 PF00583.25 KOS23026.1 - 6.4e-08 32.9 0.0 9.7e-08 32.3 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS23026.1 - 1.7e-05 24.7 0.0 2.6e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 KOS23026.1 - 0.00034 21.0 0.0 0.00052 20.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS23026.1 - 0.0032 17.4 0.0 0.0055 16.6 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein TEX13 PF15186.6 KOS23027.1 - 0.0036 17.0 10.2 0.0064 16.2 10.2 1.4 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family UPF0242 PF06785.11 KOS23027.1 - 1.2 9.2 12.0 1.8 8.7 12.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 KOS23027.1 - 3.7 6.9 16.1 6.9 6.0 16.1 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 BCS1_N PF08740.11 KOS23030.1 - 5.9e-54 182.9 0.0 5.9e-54 182.9 0.0 3.0 3 1 0 3 3 2 1 BCS1 N terminal AAA PF00004.29 KOS23030.1 - 4.7e-15 56.2 0.0 2.1e-13 50.8 0.0 2.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 KOS23030.1 - 0.0052 16.6 26.4 0.59 9.9 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 KOS23030.1 - 0.0058 17.0 0.0 0.0058 17.0 0.0 2.3 3 0 0 3 3 2 1 AAA ATPase domain AAA_5 PF07728.14 KOS23030.1 - 0.0062 16.5 0.4 0.042 13.8 0.0 2.5 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 KOS23030.1 - 0.012 15.2 0.1 0.033 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 KOS23030.1 - 0.049 13.4 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Drf_DAD PF06345.11 KOS23030.1 - 0.072 13.1 1.8 0.17 12.0 1.8 1.6 1 0 0 1 1 1 0 DRF Autoregulatory Domain ABC_membrane PF00664.23 KOS23030.1 - 0.09 12.4 1.2 0.17 11.5 1.2 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region Presenilin PF01080.17 KOS23030.1 - 4.1 6.1 26.2 7.4 5.2 26.2 1.5 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 KOS23030.1 - 4.2 6.0 20.3 7.6 5.2 20.3 1.4 1 0 0 1 1 1 0 Raftlin Glyco_hydro_47 PF01532.20 KOS23031.1 - 4.4e-134 447.8 0.0 5.4e-133 444.2 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 WD40 PF00400.32 KOS23032.1 - 1.7e-23 82.4 18.7 8.2e-06 26.5 0.1 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS23032.1 - 1.5e-12 47.6 4.9 9.1e-05 22.7 0.0 4.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 KOS23032.1 - 2.1e-05 24.6 5.5 0.1 12.5 0.2 3.6 2 2 0 2 2 2 2 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 KOS23032.1 - 0.015 14.3 0.3 2.7 6.9 0.0 3.6 2 2 3 5 5 5 0 WD40 region of Ge1, enhancer of mRNA-decapping protein GCS PF03074.16 KOS23034.1 - 1.2e-174 580.9 0.0 1.5e-174 580.6 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase DUF2373 PF10180.9 KOS23035.1 - 6.7e-22 77.1 0.0 1.2e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) BUD22 PF09073.10 KOS23035.1 - 3.5 6.9 44.6 0.12 11.7 29.4 2.4 2 0 0 2 2 2 0 BUD22 PhyH PF05721.13 KOS23036.1 - 1.3e-59 202.0 0.0 1.6e-59 201.7 0.0 1.1 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) 2OG-FeII_Oxy_5 PF13759.6 KOS23036.1 - 0.11 12.9 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative 2OG-Fe(II) oxygenase DUF4173 PF13777.6 KOS23037.1 - 0.0011 18.4 1.5 0.0011 18.4 1.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4173) MARVEL PF01284.23 KOS23037.1 - 2.7 8.0 15.0 21 5.1 15.0 2.4 1 1 0 1 1 1 0 Membrane-associating domain DUF2518 PF10726.9 KOS23037.1 - 3.1 7.5 7.0 12 5.6 2.9 2.4 1 1 1 2 2 2 0 Protein of function (DUF2518) CN_hydrolase PF00795.22 KOS23038.1 - 1.1e-58 198.6 0.0 1.3e-58 198.4 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Spermine_synth PF01564.17 KOS23039.1 - 4.4e-72 241.4 0.0 6.9e-72 240.8 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 KOS23039.1 - 7.3e-26 89.8 0.2 1.2e-25 89.1 0.2 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 KOS23039.1 - 0.00019 22.0 0.0 0.00033 21.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS23039.1 - 0.00049 19.9 0.0 0.0011 18.8 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS23039.1 - 0.012 16.4 0.2 0.062 14.0 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF43 PF01861.16 KOS23039.1 - 0.03 13.6 0.0 0.047 12.9 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_18 PF12847.7 KOS23039.1 - 0.084 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain G-alpha PF00503.20 KOS23040.1 - 2.3e-83 280.3 0.0 2.6e-83 280.1 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 KOS23040.1 - 1.2e-08 34.7 0.1 2.5e-08 33.6 0.1 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Fn3-like PF14310.6 KOS23042.1 - 1.4e-23 82.8 0.2 2.4e-23 82.0 0.2 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Glyco_hydro_3_C PF01915.22 KOS23042.1 - 6.3e-19 68.7 0.0 1e-17 64.8 0.0 2.1 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Pkinase PF00069.25 KOS23043.1 - 6.7e-19 68.3 0.0 2.1e-18 66.7 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS23043.1 - 1.2e-09 37.9 0.0 9.1e-09 35.0 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1515 PF07439.11 KOS23043.1 - 0.078 13.0 0.2 16 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DCB PF16213.5 KOS23043.1 - 0.094 12.4 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 SKG6 PF08693.10 KOS23043.1 - 0.48 9.9 3.5 1.1 8.8 3.5 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SIR2 PF02146.17 KOS23044.1 - 2.1e-56 190.6 0.0 3.3e-56 190.0 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF592 PF04574.13 KOS23044.1 - 0.0039 17.0 0.0 0.0085 15.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF592) TPP_enzyme_M PF00205.22 KOS23044.1 - 0.0071 16.1 0.1 0.74 9.6 0.1 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain zf-primase PF09329.11 KOS23045.1 - 2.1e-19 69.1 1.3 3.8e-19 68.2 1.3 1.5 1 0 0 1 1 1 1 Primase zinc finger Tyrosinase PF00264.20 KOS23046.1 - 2.6e-43 148.9 3.5 4.8e-43 148.0 3.5 1.4 1 0 0 1 1 1 1 Common central domain of tyrosinase RNase_H2-Ydr279 PF09468.10 KOS23048.1 - 1e-42 146.1 0.2 1e-42 146.1 0.2 2.2 2 1 0 2 2 2 1 Ydr279p protein family (RNase H2 complex component) wHTH domain SprA-related PF12118.8 KOS23048.1 - 0.0015 17.8 10.4 0.0021 17.3 10.4 1.1 1 0 0 1 1 1 1 SprA-related family DUF1682 PF07946.14 KOS23048.1 - 0.013 14.8 6.0 0.019 14.2 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Pyr_redox_2 PF07992.14 KOS23049.1 - 5.7e-15 55.3 0.0 4.2e-13 49.2 0.0 2.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS23049.1 - 0.00018 20.8 0.0 0.024 13.9 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS23049.1 - 0.00024 20.3 0.0 0.00045 19.4 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS23049.1 - 0.0017 18.0 0.5 0.0052 16.4 0.2 1.8 2 1 0 2 2 2 1 FAD dependent oxidoreductase GIDA PF01134.22 KOS23049.1 - 0.0024 17.0 1.1 0.2 10.7 0.6 2.2 1 1 0 2 2 2 1 Glucose inhibited division protein A HI0933_like PF03486.14 KOS23049.1 - 0.0037 16.0 0.1 0.008 14.9 0.0 1.5 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 KOS23049.1 - 0.0056 16.0 0.1 0.011 15.0 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_9 PF13454.6 KOS23049.1 - 0.006 16.6 0.2 1.3 9.0 0.1 2.2 2 0 0 2 2 2 1 FAD-NAD(P)-binding Thi4 PF01946.17 KOS23049.1 - 0.0073 15.6 0.0 0.16 11.1 0.1 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_8 PF13450.6 KOS23049.1 - 0.0099 16.1 0.2 0.026 14.8 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 KOS23049.1 - 0.044 12.9 0.1 3.2 6.8 0.0 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_oxidored PF12831.7 KOS23049.1 - 0.11 11.8 0.2 0.18 11.1 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase AFOR_C PF01314.18 KOS23049.1 - 0.15 11.0 0.0 0.21 10.5 0.0 1.1 1 0 0 1 1 1 0 Aldehyde ferredoxin oxidoreductase, domains 2 & 3 Glyco_hydro_18 PF00704.28 KOS23050.1 - 1.5e-20 74.2 3.2 7.9e-19 68.5 3.2 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 Caerin_1 PF07440.12 KOS23050.1 - 0.15 12.2 1.9 0.28 11.3 1.9 1.5 1 0 0 1 1 1 0 Caerin 1 protein ABC_membrane PF00664.23 KOS23051.1 - 5.6e-98 327.9 35.5 1.9e-51 175.3 11.6 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOS23051.1 - 2e-47 161.2 0.0 4.5e-36 124.4 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOS23051.1 - 7.7e-17 61.5 0.6 1.4e-06 28.0 0.1 3.3 3 0 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 KOS23051.1 - 7.4e-07 29.3 0.2 0.052 13.3 0.0 2.7 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC_ATPase PF09818.9 KOS23051.1 - 0.00011 21.2 3.4 0.04 12.7 0.4 3.1 3 0 0 3 3 3 2 Predicted ATPase of the ABC class AAA_22 PF13401.6 KOS23051.1 - 0.00029 21.1 0.0 0.0043 17.3 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 KOS23051.1 - 0.00068 19.3 0.0 0.0016 18.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOS23051.1 - 0.003 17.5 0.1 0.0097 15.8 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase AAA_30 PF13604.6 KOS23051.1 - 0.0093 15.7 0.1 0.035 13.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS23051.1 - 0.01 16.2 0.4 0.055 13.8 0.1 2.3 2 1 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 KOS23051.1 - 0.028 14.5 0.2 0.063 13.4 0.2 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_15 PF13175.6 KOS23051.1 - 0.093 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Gp138_N PF18352.1 KOS23051.1 - 0.099 12.7 0.0 12 6.0 0.0 2.6 2 0 0 2 2 2 0 Phage protein Gp138 N-terminal domain MMR_HSR1 PF01926.23 KOS23051.1 - 0.1 12.7 0.2 0.91 9.6 0.0 2.6 3 0 0 3 3 3 0 50S ribosome-binding GTPase NACHT PF05729.12 KOS23051.1 - 0.14 12.1 0.2 0.88 9.5 0.0 2.2 2 0 0 2 2 2 0 NACHT domain ATP-synt_ab PF00006.25 KOS23051.1 - 0.16 11.6 0.2 1 9.0 0.0 2.3 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain SbcCD_C PF13558.6 KOS23051.1 - 0.19 12.0 9.8 0.7 10.2 0.3 4.4 4 2 0 4 4 3 0 Putative exonuclease SbcCD, C subunit DegT_DnrJ_EryC1 PF01041.17 KOS23053.1 - 7.6e-62 209.7 0.0 1.5e-61 208.7 0.0 1.3 1 1 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family GFO_IDH_MocA PF01408.22 KOS23053.1 - 2.7e-16 60.5 0.0 6.1e-16 59.3 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.19 KOS23053.1 - 1.2e-06 29.1 0.0 3e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain GFO_IDH_MocA_C PF02894.17 KOS23053.1 - 1.9e-06 27.9 0.0 5.8e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Beta_elim_lyase PF01212.21 KOS23053.1 - 0.00011 21.5 0.0 0.00019 20.9 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 KOS23053.1 - 0.0076 14.8 0.0 0.013 14.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOS23053.1 - 0.013 14.5 0.0 0.02 13.8 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class-V ADP_PFK_GK PF04587.15 KOS23053.1 - 0.084 11.4 0.0 0.14 10.7 0.0 1.2 1 0 0 1 1 1 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Semialdhyde_dh PF01118.24 KOS23053.1 - 0.12 12.8 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain PEX11 PF05648.14 KOS23054.1 - 5.9e-69 231.9 0.2 6.6e-69 231.8 0.2 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) BBE PF08031.12 KOS23055.1 - 5e-12 45.7 0.1 1.4e-11 44.3 0.1 1.8 1 0 0 1 1 1 1 Berberine and berberine like FAD_binding_4 PF01565.23 KOS23055.1 - 3.9e-11 42.9 2.0 7.2e-11 42.0 0.5 2.1 1 1 2 3 3 3 1 FAD binding domain Methyltransf_25 PF13649.6 KOS23056.1 - 7.2e-14 52.3 0.0 1.1e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS23056.1 - 1.5e-09 38.3 0.0 2.4e-09 37.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS23056.1 - 7.2e-09 36.3 0.0 1.1e-08 35.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS23056.1 - 3.9e-07 30.0 0.0 5.8e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS23056.1 - 2.5e-05 24.2 0.0 3.6e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 KOS23056.1 - 6.1e-05 22.3 0.0 0.002 17.3 0.0 2.1 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family MTS PF05175.14 KOS23056.1 - 6.1e-05 22.6 0.0 9.6e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 KOS23056.1 - 0.00037 19.9 0.0 0.00052 19.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 KOS23056.1 - 0.00068 19.0 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_PK PF05891.12 KOS23056.1 - 0.012 15.2 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Cons_hypoth95 PF03602.15 KOS23056.1 - 0.018 14.7 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_24 PF13578.6 KOS23056.1 - 0.1 13.6 0.0 0.17 12.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Pox_MCEL PF03291.16 KOS23056.1 - 0.11 11.6 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 mRNA capping enzyme ABC_membrane PF00664.23 KOS23057.1 - 3.7e-84 282.6 32.6 4.2e-47 161.1 12.0 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 KOS23057.1 - 4.3e-70 234.6 0.0 1.3e-34 119.7 0.1 2.4 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 KOS23057.1 - 2e-17 63.4 2.0 8.4e-05 22.1 0.6 4.3 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 KOS23057.1 - 3.9e-10 40.4 0.4 0.00027 21.4 0.0 3.1 3 0 0 3 3 2 2 AAA ATPase domain AAA_22 PF13401.6 KOS23057.1 - 1.8e-08 34.8 0.1 0.0063 16.8 0.0 3.8 2 2 0 2 2 2 2 AAA domain AAA_29 PF13555.6 KOS23057.1 - 2e-08 33.9 0.4 0.0059 16.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 KOS23057.1 - 2.3e-07 31.5 0.0 0.022 15.3 0.0 2.4 2 0 0 2 2 2 2 AAA domain ABC_ATPase PF09818.9 KOS23057.1 - 6.3e-07 28.5 0.4 0.0087 14.9 0.0 2.6 3 0 0 3 3 2 2 Predicted ATPase of the ABC class RsgA_GTPase PF03193.16 KOS23057.1 - 7.1e-07 29.3 0.0 0.07 13.0 0.0 3.4 3 0 0 3 3 3 2 RsgA GTPase AAA_15 PF13175.6 KOS23057.1 - 1.5e-06 28.2 0.0 0.062 13.0 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_21 PF13304.6 KOS23057.1 - 1.1e-05 25.4 0.3 0.9 9.3 0.0 3.3 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_7 PF12775.7 KOS23057.1 - 6.1e-05 22.6 0.0 0.067 12.7 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region DEAD PF00270.29 KOS23057.1 - 9.8e-05 22.2 0.5 1.3 8.8 0.1 3.4 2 2 0 2 2 2 2 DEAD/DEAH box helicase SbcCD_C PF13558.6 KOS23057.1 - 0.00022 21.4 2.1 0.08 13.2 0.2 3.3 2 2 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Mg_chelatase PF01078.21 KOS23057.1 - 0.00023 20.6 0.0 0.25 10.7 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 KOS23057.1 - 0.00046 20.0 0.8 1 9.0 0.1 4.1 3 2 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 KOS23057.1 - 0.0008 19.2 1.7 0.51 10.1 0.0 3.9 5 0 0 5 5 4 1 IstB-like ATP binding protein AAA_5 PF07728.14 KOS23057.1 - 0.00086 19.3 0.1 7.6 6.5 0.0 3.9 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) DUF87 PF01935.17 KOS23057.1 - 0.00092 19.4 1.0 1.7 8.7 0.1 2.7 2 1 0 2 2 2 2 Helicase HerA, central domain AAA_24 PF13479.6 KOS23057.1 - 0.0031 17.2 0.0 3.3 7.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 KOS23057.1 - 0.0034 17.8 3.5 14 6.1 0.1 4.4 2 2 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 KOS23057.1 - 0.0061 16.2 2.2 5.1 6.6 0.0 3.8 4 0 0 4 4 3 0 AAA domain MMR_HSR1 PF01926.23 KOS23057.1 - 0.0069 16.4 1.7 2.8 8.1 0.0 3.7 4 0 0 4 4 3 1 50S ribosome-binding GTPase Cytidylate_kin PF02224.18 KOS23057.1 - 0.0071 16.1 0.0 0.46 10.2 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase Zeta_toxin PF06414.12 KOS23057.1 - 0.0076 15.6 0.0 0.74 9.1 0.0 2.3 2 0 0 2 2 2 1 Zeta toxin Sigma54_activat PF00158.26 KOS23057.1 - 0.0083 15.8 0.0 2.3 7.9 0.0 3.0 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_33 PF13671.6 KOS23057.1 - 0.011 15.9 0.0 5.9 7.0 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 KOS23057.1 - 0.013 16.0 0.0 14 6.3 0.0 3.1 3 0 0 3 3 2 0 AAA domain NB-ARC PF00931.22 KOS23057.1 - 0.013 14.7 0.0 2.8 7.0 0.0 2.7 3 0 0 3 3 3 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 KOS23057.1 - 0.03 13.7 0.2 5.7 6.2 0.0 3.1 3 0 0 3 3 3 0 FtsK/SpoIIIE family T2SSE PF00437.20 KOS23057.1 - 0.034 13.2 0.0 0.56 9.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein APS_kinase PF01583.20 KOS23057.1 - 0.037 13.9 0.1 3.3 7.6 0.0 2.8 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_10 PF12846.7 KOS23057.1 - 0.04 12.8 0.0 1.4 7.8 0.0 2.2 2 0 0 2 2 2 0 AAA-like domain G-alpha PF00503.20 KOS23057.1 - 0.045 12.9 0.0 0.38 9.8 0.0 2.0 2 0 0 2 2 2 0 G-protein alpha subunit RNA_helicase PF00910.22 KOS23057.1 - 0.062 13.7 0.0 29 5.1 0.0 3.3 3 0 0 3 3 2 0 RNA helicase Gtr1_RagA PF04670.12 KOS23057.1 - 0.096 12.0 0.1 5.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 KOS23057.1 - 0.17 11.6 0.1 5.5 6.7 0.0 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Ank_2 PF12796.7 KOS23058.1 - 3.5e-19 69.2 2.6 3.9e-11 43.4 0.3 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS23058.1 - 2.1e-14 53.7 0.2 4.9e-10 39.7 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS23058.1 - 7.9e-10 38.1 1.1 0.07 13.7 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank PF00023.30 KOS23058.1 - 9.8e-10 38.4 4.4 0.013 15.9 0.3 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 KOS23058.1 - 3.3e-09 36.8 3.0 0.0012 19.1 0.1 3.4 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Herpes_capsid PF06112.11 KOS23058.1 - 0.09 12.8 11.8 0.19 11.8 11.8 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Bacteroid_pep PF14406.6 KOS23058.1 - 0.44 10.9 0.2 0.44 10.9 0.2 2.3 2 0 0 2 2 2 0 Ribosomally synthesized peptide in Bacteroidetes YCII PF03795.14 KOS23059.1 - 0.062 13.7 0.0 0.086 13.3 0.0 1.1 1 0 0 1 1 1 0 YCII-related domain PXA PF02194.15 KOS23060.1 - 5.4e-51 173.2 0.0 2.2e-50 171.2 0.0 2.1 1 0 0 1 1 1 1 PXA domain Nexin_C PF08628.12 KOS23060.1 - 1.9e-27 96.1 0.0 5.1e-27 94.7 0.0 1.8 1 0 0 1 1 1 1 Sorting nexin C terminal PX PF00787.24 KOS23060.1 - 1e-19 70.6 0.5 1e-19 70.6 0.5 1.9 2 0 0 2 2 2 1 PX domain RGS PF00615.19 KOS23060.1 - 2.4e-12 47.1 0.0 7.9e-12 45.5 0.0 2.0 1 0 0 1 1 1 1 Regulator of G protein signaling domain Rbsn PF11464.8 KOS23060.1 - 0.19 11.5 1.3 0.47 10.2 1.3 1.7 1 0 0 1 1 1 0 Rabenosyn Rab binding domain DUF3245 PF11595.8 KOS23060.1 - 0.26 11.8 2.6 0.73 10.3 2.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) RRM_1 PF00076.22 KOS23061.1 - 7.4e-10 38.5 0.0 9.1e-10 38.2 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Chitin_synth_1 PF01644.17 KOS23063.1 - 2.2e-73 245.6 0.2 3.5e-73 245.0 0.2 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 KOS23063.1 - 7.9e-28 96.2 0.1 1.8e-27 95.0 0.1 1.7 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 KOS23063.1 - 3.3e-22 78.8 4.6 2.3e-17 62.8 0.0 2.2 2 0 0 2 2 2 2 Chitin synthase Glyco_trans_2_3 PF13632.6 KOS23063.1 - 1.2e-05 25.4 13.3 2e-05 24.6 8.4 3.2 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Pro-kuma_activ PF09286.11 KOS23064.1 - 3.9e-21 75.8 0.0 9.2e-21 74.6 0.0 1.5 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Peptidase_S8 PF00082.22 KOS23064.1 - 0.0012 18.2 0.0 0.0031 16.8 0.0 1.7 1 1 0 1 1 1 1 Subtilase family Translin PF01997.16 KOS23065.1 - 5e-45 154.0 0.0 5.8e-45 153.8 0.0 1.0 1 0 0 1 1 1 1 Translin family DUF5631 PF18645.1 KOS23065.1 - 0.062 13.7 0.7 8.9 6.8 0.1 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5631) zf-CCCH_4 PF18044.1 KOS23066.1 - 3.5e-07 29.9 3.0 5.4e-07 29.3 3.0 1.3 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 KOS23066.1 - 6.7e-06 26.0 5.3 1.1e-05 25.3 5.3 1.4 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 KOS23066.1 - 0.00016 21.5 3.8 0.00029 20.7 3.8 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 KOS23066.1 - 0.0049 17.1 0.3 0.0049 17.1 0.3 2.6 2 1 0 2 2 2 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 KOS23066.1 - 0.013 16.0 1.6 0.022 15.2 1.6 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Sec1 PF00995.23 KOS23067.1 - 2.4e-130 436.5 0.0 2.7e-130 436.3 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Ino80_Iec3 PF14612.6 KOS23068.1 - 3.8e-52 178.3 0.9 9.1e-52 177.1 0.0 2.1 2 1 0 2 2 2 1 IEC3 subunit of the Ino80 complex, chromatin re-modelling TMF_DNA_bd PF12329.8 KOS23068.1 - 0.02 14.8 0.4 0.041 13.9 0.4 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Nucleo_P87 PF07267.11 KOS23068.1 - 0.9 8.3 10.6 1.4 7.7 10.6 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Iso_dh PF00180.20 KOS23069.1 - 2.7e-70 237.3 0.0 3.1e-70 237.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase adh_short_C2 PF13561.6 KOS23070.1 - 2.1e-50 171.5 0.2 2.4e-50 171.3 0.2 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS23070.1 - 2.3e-44 151.2 0.1 4.5e-44 150.3 0.0 1.5 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 KOS23070.1 - 3.8e-12 46.5 0.2 5.5e-12 46.0 0.2 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS23070.1 - 5.7e-05 22.7 1.4 0.0001 21.9 0.1 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 KOS23070.1 - 0.0033 16.9 0.0 0.0054 16.2 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 KOS23070.1 - 0.0044 16.2 0.2 0.024 13.7 0.2 2.1 1 1 0 1 1 1 1 RmlD substrate binding domain DUF1776 PF08643.10 KOS23070.1 - 0.029 13.8 0.0 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Methyltransf_19 PF04672.12 KOS23070.1 - 0.096 12.1 0.1 0.21 11.0 0.0 1.5 2 0 0 2 2 2 0 S-adenosyl methyltransferase CbiA PF01656.23 KOS23070.1 - 0.14 12.2 0.3 2.4 8.2 0.1 2.4 2 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain Filament PF00038.21 KOS23071.1 - 0.00011 21.9 17.2 0.00011 21.9 17.2 4.3 3 1 1 5 5 5 1 Intermediate filament protein DUF4200 PF13863.6 KOS23071.1 - 0.00078 19.8 9.7 0.00078 19.8 9.7 6.3 5 1 1 6 6 6 1 Domain of unknown function (DUF4200) ATG16 PF08614.11 KOS23071.1 - 0.00088 19.5 22.1 0.00088 19.5 22.1 5.0 4 2 1 5 5 5 1 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 KOS23071.1 - 0.062 13.7 25.2 1.9 8.9 0.1 6.7 7 0 0 7 7 7 0 Flagella accessory protein C (FlaC) Taxilin PF09728.9 KOS23071.1 - 0.17 11.0 41.3 0.015 14.5 5.5 4.1 3 1 1 4 4 4 0 Myosin-like coiled-coil protein TSC22 PF01166.18 KOS23071.1 - 0.3 11.4 0.1 0.3 11.4 0.1 5.0 6 1 0 6 6 6 0 TSC-22/dip/bun family Shugoshin_N PF07558.11 KOS23071.1 - 9 6.3 15.1 2.1 8.3 0.3 4.7 5 0 0 5 5 5 0 Shugoshin N-terminal coiled-coil region S4 PF01479.25 KOS23072.1 - 1.2e-12 47.3 0.0 3.4e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 KOS23072.1 - 5.6e-10 40.0 1.4 8.6e-10 39.4 1.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Herpes_LAMP2 PF06126.11 KOS23072.1 - 0.052 12.2 0.1 0.059 12.0 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 Ribosomal_S18 PF01084.20 KOS23073.1 - 3.2e-09 36.9 0.0 6.2e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S18 DUF5094 PF17015.5 KOS23073.1 - 0.2 11.8 0.6 0.29 11.2 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) TFIIF_alpha PF05793.12 KOS23073.1 - 1.7 7.2 5.9 2.2 6.8 5.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PI3K_1B_p101 PF10486.9 KOS23073.1 - 2.3 5.9 5.5 2.8 5.6 5.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SNF2_N PF00176.23 KOS23074.1 - 1.5e-25 89.7 0.3 2.1e-25 89.2 0.3 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain VIGSSK PF14773.6 KOS23074.1 - 9.3e-24 83.3 1.9 1.9e-23 82.3 1.9 1.6 1 0 0 1 1 1 1 Helicase-associated putative binding domain, C-terminal Helicase_C PF00271.31 KOS23074.1 - 5.1e-19 68.7 0.0 3.9e-18 65.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 KOS23074.1 - 3e-06 26.6 0.0 8.3e-06 25.2 0.0 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 KOS23074.1 - 0.0036 17.0 0.0 0.0083 15.8 0.0 1.5 1 0 0 1 1 1 1 SWI2/SNF2 ATPase ResIII PF04851.15 KOS23074.1 - 0.0061 16.6 0.0 0.025 14.6 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Methyltransf_23 PF13489.6 KOS23075.1 - 1.1e-10 41.6 0.0 1.7e-10 41.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS23075.1 - 2.5e-07 31.2 0.0 6.1e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS23075.1 - 2.3e-06 28.2 0.0 4.5e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS23075.1 - 7.3e-06 26.6 0.0 1.9e-05 25.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS23075.1 - 0.0013 18.6 0.0 0.0019 18.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 KOS23075.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family EamA PF00892.20 KOS23076.1 - 2.7e-07 30.8 31.1 0.0016 18.6 8.9 2.9 2 1 0 2 2 2 2 EamA-like transporter family CSG2 PF16965.5 KOS23076.1 - 0.0012 17.9 7.1 0.0012 17.9 7.1 2.7 2 1 0 2 2 2 1 Ceramide synthase regulator AMP-binding PF00501.28 KOS23077.1 - 7.8e-77 258.6 0.0 1.3e-76 257.9 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme Condensation PF00668.20 KOS23077.1 - 1.7e-68 231.4 0.0 2.7e-68 230.7 0.0 1.2 1 0 0 1 1 1 1 Condensation domain ketoacyl-synt PF00109.26 KOS23077.1 - 1.9e-60 204.6 0.0 3.4e-60 203.8 0.0 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain KR PF08659.10 KOS23077.1 - 3.9e-58 196.3 2.7 6e-58 195.7 0.0 2.7 3 0 0 3 3 3 1 KR domain PS-DH PF14765.6 KOS23077.1 - 1.3e-55 188.8 0.0 2.1e-55 188.1 0.0 1.3 1 0 0 1 1 1 1 Polyketide synthase dehydratase Acyl_transf_1 PF00698.21 KOS23077.1 - 1.8e-54 185.4 0.0 3e-54 184.7 0.0 1.3 1 0 0 1 1 1 1 Acyl transferase domain Ketoacyl-synt_C PF02801.22 KOS23077.1 - 1.8e-38 131.2 0.1 8.2e-38 129.1 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain NAD_binding_4 PF07993.12 KOS23077.1 - 1.1e-37 129.6 0.0 2.6e-37 128.4 0.0 1.7 1 0 0 1 1 1 1 Male sterility protein KAsynt_C_assoc PF16197.5 KOS23077.1 - 3e-19 69.5 0.0 9.4e-19 67.9 0.0 2.0 1 0 0 1 1 1 1 Ketoacyl-synthetase C-terminal extension PP-binding PF00550.25 KOS23077.1 - 5.8e-19 68.2 0.0 6.9e-08 32.7 0.0 3.3 2 0 0 2 2 2 2 Phosphopantetheine attachment site ADH_zinc_N PF00107.26 KOS23077.1 - 4.2e-15 55.9 0.0 1.5e-14 54.1 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS23077.1 - 2.4e-14 54.5 0.0 1.6e-13 51.9 0.0 2.5 2 0 0 2 2 1 1 Zinc-binding dehydrogenase adh_short PF00106.25 KOS23077.1 - 1.8e-08 34.1 0.4 6.3e-08 32.3 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase ADH_N PF08240.12 KOS23077.1 - 3.5e-05 23.6 0.0 0.0001 22.2 0.0 1.8 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Thiolase_N PF00108.23 KOS23077.1 - 0.018 14.4 0.0 0.053 12.9 0.0 1.7 1 0 0 1 1 1 0 Thiolase, N-terminal domain AMP-binding_C PF13193.6 KOS23077.1 - 0.02 15.8 0.0 0.074 14.0 0.0 2.0 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain PPR PF01535.20 KOS23078.1 - 4.7e-06 26.5 1.5 1.4 9.4 0.0 5.8 6 0 0 6 6 6 2 PPR repeat PPR_2 PF13041.6 KOS23078.1 - 7.1e-06 26.1 0.0 15 5.8 0.0 5.5 5 1 1 6 6 6 2 PPR repeat family PPR_3 PF13812.6 KOS23078.1 - 9.8e-06 25.6 0.0 0.013 15.5 0.0 4.0 3 1 1 4 4 4 1 Pentatricopeptide repeat domain PPR_long PF17177.4 KOS23078.1 - 0.0033 16.8 0.0 0.58 9.5 0.0 2.8 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP Aldo_ket_red PF00248.21 KOS23079.1 - 1.4e-48 165.7 0.0 1.6e-48 165.5 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family ExbD PF02472.16 KOS23079.1 - 0.17 12.1 0.0 0.66 10.2 0.0 1.8 1 1 0 2 2 2 0 Biopolymer transport protein ExbD/TolR FAD_binding_3 PF01494.19 KOS23081.1 - 5.3e-17 62.1 0.1 1.7e-14 53.9 0.1 2.8 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 KOS23081.1 - 0.003 17.8 0.1 0.003 17.8 0.1 2.0 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 KOS23081.1 - 0.0056 16.0 0.0 0.16 11.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS23081.1 - 0.021 14.1 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Thi4 family Pyr_redox PF00070.27 KOS23081.1 - 0.048 14.2 0.5 0.092 13.3 0.1 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 KOS23081.1 - 0.075 12.3 0.0 0.62 9.3 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 KOS23081.1 - 0.079 12.0 0.6 0.15 11.1 0.6 1.5 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 KOS23081.1 - 0.08 11.8 0.2 0.21 10.4 0.1 1.6 1 1 0 2 2 2 0 Tryptophan halogenase TGFb_propeptide PF00688.18 KOS23081.1 - 0.11 12.2 0.5 1.4 8.6 0.1 2.0 2 0 0 2 2 2 0 TGF-beta propeptide Pyr_redox_3 PF13738.6 KOS23081.1 - 0.24 10.6 0.2 0.36 10.0 0.2 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase LBP_M PF17385.2 KOS23082.1 - 0.38 10.2 3.5 0.71 9.4 3.5 1.4 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain Pkinase PF00069.25 KOS23083.1 - 1.9e-70 237.3 0.0 3.9e-70 236.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS23083.1 - 2.6e-49 167.8 0.0 4e-49 167.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS23083.1 - 0.00013 20.9 0.0 0.00022 20.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS23083.1 - 0.0033 16.8 0.0 0.014 14.8 0.1 1.9 2 0 0 2 2 2 1 Kinase-like RIH_assoc PF08454.11 KOS23083.1 - 0.5 10.2 2.1 1.1 9.2 0.6 2.2 2 0 0 2 2 2 0 RyR and IP3R Homology associated ICE2 PF08426.10 KOS23084.1 - 6.7e-156 519.5 8.9 7.6e-156 519.3 8.9 1.0 1 0 0 1 1 1 1 ICE2 Aa_trans PF01490.18 KOS23085.1 - 1.4e-20 73.5 30.1 1.6e-20 73.2 30.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein MFS_1 PF07690.16 KOS23087.1 - 3e-19 69.2 37.0 4.1e-19 68.7 31.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily adh_short PF00106.25 KOS23088.1 - 0.026 14.0 0.0 0.057 12.9 0.0 1.7 1 0 0 1 1 1 0 short chain dehydrogenase DUF2615 PF11027.8 KOS23088.1 - 0.12 12.5 0.1 22 5.3 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) KH_1 PF00013.29 KOS23089.1 - 2.1e-91 299.7 30.0 6.5e-13 48.3 0.1 14.1 14 0 0 14 14 14 9 KH domain KH_2 PF07650.17 KOS23089.1 - 1.4e-10 40.9 21.4 0.066 13.0 0.3 8.0 7 1 1 8 8 8 4 KH domain SLS PF14611.6 KOS23089.1 - 2.5e-07 30.7 10.4 0.86 9.4 0.0 7.1 5 3 2 8 8 8 3 Mitochondrial inner-membrane-bound regulator KH_5 PF13184.6 KOS23089.1 - 0.0047 17.0 7.6 42 4.3 0.0 6.4 7 0 0 7 7 7 0 NusA-like KH domain KH_4 PF13083.6 KOS23089.1 - 0.019 14.8 13.8 2 8.3 0.0 5.9 6 1 0 6 6 6 0 KH domain BON PF04972.17 KOS23089.1 - 0.028 14.7 0.5 7.9 6.9 0.0 3.8 3 0 0 3 3 3 0 BON domain FCD PF07729.12 KOS23089.1 - 0.037 14.4 2.7 0.048 14.1 0.1 2.7 2 0 0 2 2 2 0 FCD domain Dermcidin PF15291.6 KOS23089.1 - 5.4 7.6 10.7 2.8 8.5 3.0 3.4 3 1 0 3 3 3 0 Dermcidin, antibiotic peptide Pkinase PF00069.25 KOS23090.1 - 1.1e-72 244.6 0.0 1.7e-72 244.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS23090.1 - 8.8e-47 159.6 0.0 1.6e-46 158.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 KOS23090.1 - 1.8e-17 63.4 0.0 1.8e-17 63.4 0.0 2.7 2 0 0 2 2 2 1 P21-Rho-binding domain Kinase-like PF14531.6 KOS23090.1 - 6.2e-08 32.3 0.0 1.1e-07 31.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 KOS23090.1 - 1.1e-06 27.7 0.0 1.1e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase TFIIA PF03153.13 KOS23090.1 - 0.038 14.0 30.0 0.078 13.0 14.6 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Kdo PF06293.14 KOS23090.1 - 0.071 12.5 0.0 0.071 12.5 0.0 2.2 3 0 0 3 3 3 0 Lipopolysaccharide kinase (Kdo/WaaP) family adh_short_C2 PF13561.6 KOS23091.1 - 4.3e-61 206.4 1.2 5.9e-61 206.0 1.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS23091.1 - 2.7e-50 170.5 1.0 4e-50 170.0 1.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS23091.1 - 1.3e-11 44.8 0.5 1.9e-11 44.2 0.5 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS23091.1 - 1.1e-05 25.0 0.2 2.2e-05 24.0 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family PA PF02225.22 KOS23091.1 - 0.0026 17.7 0.1 0.0075 16.3 0.1 1.8 1 0 0 1 1 1 1 PA domain GDP_Man_Dehyd PF16363.5 KOS23091.1 - 0.0045 16.4 0.1 0.01 15.2 0.1 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 KOS23091.1 - 0.0049 16.1 0.0 0.011 14.9 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein ARID PF01388.21 KOS23093.1 - 7.8e-17 61.7 0.1 2.1e-16 60.4 0.1 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain Tim54 PF11711.8 KOS23093.1 - 0.17 10.6 1.8 0.34 9.6 1.8 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 KOS23093.1 - 0.19 10.5 9.6 0.41 9.4 9.6 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2_3rep PF18868.1 KOS23093.1 - 0.91 10.2 0.0 0.91 10.2 0.0 2.5 2 0 0 2 2 1 0 Zinc finger C2H2-type, 3 repeats NOA36 PF06524.12 KOS23093.1 - 1.6 7.9 9.3 2.7 7.2 9.3 1.2 1 0 0 1 1 1 0 NOA36 protein NST1 PF13945.6 KOS23093.1 - 1.8 8.6 26.1 3.6 7.6 26.1 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator SOG2 PF10428.9 KOS23093.1 - 2 7.5 10.8 3.3 6.8 10.8 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Zip PF02535.22 KOS23093.1 - 3.1 6.9 6.0 4.6 6.3 6.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 KOS23093.1 - 3.2 6.4 10.2 4.8 5.8 10.2 1.1 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 KOS23093.1 - 4 7.5 12.7 7.5 6.6 12.7 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 KOS23093.1 - 7.9 5.4 8.5 13 4.7 8.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DUF4551 PF15087.6 KOS23093.1 - 9.1 5.0 6.3 18 4.0 6.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 KOS23093.1 - 9.4 4.6 13.8 14 4.1 13.8 1.1 1 0 0 1 1 1 0 Macoilin family Dioxygenase_C PF00775.21 KOS23094.1 - 2.7e-40 137.7 0.0 3.5e-40 137.4 0.0 1.1 1 0 0 1 1 1 1 Dioxygenase Dioxygenase_N PF04444.14 KOS23094.1 - 1.9e-25 88.5 0.1 2.7e-25 88.0 0.1 1.2 1 0 0 1 1 1 1 Catechol dioxygenase N terminus Lactonase PF10282.9 KOS23095.1 - 2.1e-14 53.5 0.0 3.8e-14 52.7 0.0 1.3 1 1 0 1 1 1 1 Lactonase, 7-bladed beta-propeller Ribosom_S12_S23 PF00164.25 KOS23096.1 - 3.7e-51 171.5 0.6 4.7e-51 171.2 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Inhibitor_I9 PF05922.16 KOS23097.1 - 0.049 14.3 0.0 0.062 14.0 0.0 1.3 1 0 0 1 1 1 0 Peptidase inhibitor I9 HOOK PF05622.12 KOS23098.1 - 1.5e-16 59.8 49.9 1.5e-16 59.8 49.9 2.1 1 1 1 2 2 2 1 HOOK protein HMMR_N PF15905.5 KOS23098.1 - 0.00032 20.3 10.8 0.00032 20.3 10.8 4.5 2 2 2 4 4 4 1 Hyaluronan mediated motility receptor N-terminal DUF4201 PF13870.6 KOS23098.1 - 0.0039 16.9 10.0 0.0039 16.9 10.0 6.9 3 2 2 5 5 5 1 Domain of unknown function (DUF4201) Sec8_exocyst PF04048.14 KOS23098.1 - 0.016 15.1 1.3 0.016 15.1 1.3 5.5 3 1 3 6 6 6 0 Sec8 exocyst complex component specific domain Nup54_57_C PF18570.1 KOS23098.1 - 0.04 13.5 0.5 0.48 10.1 0.2 3.2 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain ThiS PF02597.20 KOS23098.1 - 0.82 10.3 10.0 12 6.6 0.0 4.8 4 1 0 4 4 4 0 ThiS family ADK PF00406.22 KOS23099.1 - 1.5e-59 200.4 0.0 2.3e-59 199.8 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 KOS23099.1 - 4.2e-22 79.0 0.2 9.3e-22 77.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 KOS23099.1 - 8.8e-18 64.0 0.0 3.2e-17 62.2 0.0 2.0 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_18 PF13238.6 KOS23099.1 - 4.8e-05 23.9 0.0 0.0001 22.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 KOS23099.1 - 5.7e-05 23.3 0.0 0.0001 22.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain BLOC1_2 PF10046.9 KOS23099.1 - 0.13 12.5 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MitMem_reg PF13012.6 KOS23100.1 - 2.3e-36 124.6 0.1 4.9e-36 123.6 0.1 1.5 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 KOS23100.1 - 1.4e-32 112.2 0.0 2.9e-32 111.1 0.0 1.5 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA_bind_2 PF13725.6 KOS23100.1 - 0.046 13.4 3.5 0.069 12.8 3.5 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain DUF2999 PF11212.8 KOS23100.1 - 0.12 12.6 0.0 0.39 11.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2999) SWIM PF04434.17 KOS23101.1 - 0.00063 19.3 1.3 0.59 9.9 0.0 2.4 2 0 0 2 2 2 2 SWIM zinc finger Atg8 PF02991.16 KOS23102.1 - 2.7e-51 172.1 0.2 3.2e-51 171.8 0.2 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 KOS23102.1 - 3e-06 27.5 0.0 3.6e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Sugar_tr PF00083.24 KOS23103.1 - 1.9e-77 261.1 20.3 2.4e-77 260.8 20.3 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS23103.1 - 5.5e-16 58.4 25.3 1.1e-12 47.6 21.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS23103.1 - 6.7e-05 21.9 13.2 9.6e-05 21.4 4.2 2.3 2 0 0 2 2 2 2 MFS_1 like family MFS_2 PF13347.6 KOS23103.1 - 0.0016 17.1 2.8 0.0016 17.1 2.8 3.1 2 1 1 3 3 3 3 MFS/sugar transport protein Complex1_LYR_2 PF13233.6 KOS23104.1 - 9.9e-21 74.3 0.0 1.3e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Inositol_P PF00459.25 KOS23105.1 - 3.6e-51 174.3 2.1 2e-50 171.8 2.1 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family DUF2630 PF10944.8 KOS23105.1 - 0.056 13.9 0.3 0.11 13.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) Sec1 PF00995.23 KOS23106.1 - 1.7e-119 400.7 0.0 2e-119 400.5 0.0 1.0 1 0 0 1 1 1 1 Sec1 family Apo-CIII PF05778.12 KOS23106.1 - 0.012 15.2 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) Exo5 PF09810.9 KOS23107.1 - 8.2e-123 410.5 0.0 1.1e-122 410.0 0.0 1.2 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease ThiF PF00899.21 KOS23108.1 - 9.8e-110 365.7 0.0 1.3e-74 250.7 0.0 2.3 2 1 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 KOS23108.1 - 6.9e-90 301.4 3.6 9e-90 301.0 2.0 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme active site E1_FCCH PF16190.5 KOS23108.1 - 4.5e-31 106.8 0.1 9.8e-31 105.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_UFD PF09358.10 KOS23108.1 - 1.4e-29 102.6 0.0 2.7e-29 101.7 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin fold domain E1_4HB PF16191.5 KOS23108.1 - 1.7e-23 82.5 1.1 4.6e-23 81.2 0.9 1.9 2 0 0 2 2 2 1 Ubiquitin-activating enzyme E1 four-helix bundle F-box-like PF12937.7 KOS23109.1 - 4.7e-08 32.8 4.0 0.00027 20.8 0.2 2.8 2 0 0 2 2 2 2 F-box-like F-box PF00646.33 KOS23109.1 - 0.0011 18.7 4.3 0.084 12.8 0.3 2.7 2 0 0 2 2 2 2 F-box domain His_Phos_1 PF00300.22 KOS23110.1 - 0.028 14.1 0.0 0.044 13.5 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) M20_dimer PF07687.14 KOS23111.1 - 1.7e-08 34.3 0.0 1.1e-06 28.5 0.0 2.9 2 1 0 2 2 2 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 KOS23111.1 - 1.9e-08 34.3 0.3 3.4e-08 33.5 0.3 1.4 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DUF4975 PF16346.5 KOS23111.1 - 0.18 11.9 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) His_Phos_1 PF00300.22 KOS23112.1 - 0.036 13.8 0.0 0.068 12.9 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) TFIIF_alpha PF05793.12 KOS23112.1 - 4.1 5.9 10.0 6.3 5.3 10.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Amino_oxidase PF01593.24 KOS23113.1 - 8.7e-50 170.3 0.1 7.4e-49 167.3 0.1 2.0 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 KOS23113.1 - 8.5e-17 61.2 0.1 2.1e-16 59.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 KOS23113.1 - 4.7e-05 23.4 0.0 0.016 15.2 0.1 2.4 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox_2 PF07992.14 KOS23113.1 - 7.1e-05 22.2 0.0 0.00022 20.6 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 KOS23113.1 - 9.8e-05 22.1 0.3 0.00024 20.8 0.0 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOS23113.1 - 0.0001 22.8 0.1 0.00047 20.6 0.1 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 KOS23113.1 - 0.00053 19.2 0.1 0.0012 18.0 0.1 1.6 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 KOS23113.1 - 0.00061 18.6 0.0 0.0012 17.6 0.0 1.4 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 KOS23113.1 - 0.0043 16.3 0.2 0.011 15.0 0.0 1.7 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 KOS23113.1 - 0.0076 15.5 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain 3HCDH_N PF02737.18 KOS23113.1 - 0.0078 16.1 0.1 0.015 15.2 0.1 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 KOS23113.1 - 0.021 14.1 0.0 0.033 13.5 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain FMO-like PF00743.19 KOS23113.1 - 0.048 12.1 0.0 0.064 11.7 0.0 1.1 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like FAD_oxidored PF12831.7 KOS23113.1 - 0.12 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 KOS23113.1 - 0.17 10.9 0.1 0.26 10.3 0.1 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A ATG2_CAD PF13329.6 KOS23114.1 - 1.5e-51 174.2 0.0 2.9e-51 173.2 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 KOS23114.1 - 7.2e-31 106.4 0.7 2.6e-29 101.4 0.0 3.6 4 0 0 4 4 4 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 KOS23114.1 - 0.086 12.6 0.0 0.5 10.1 0.0 2.1 2 0 0 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal PRIMA1 PF16101.5 KOS23114.1 - 6.7 6.8 9.6 0.068 13.2 1.3 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 Glyco_transf_8 PF01501.20 KOS23115.1 - 6.1e-14 52.2 0.0 3.3e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 8 Glyco_transf_24 PF18404.1 KOS23115.1 - 0.027 13.9 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 Glucosyltransferase 24 Ifi-6-16 PF06140.13 KOS23117.1 - 3.1e-08 33.4 30.6 3.1e-08 33.4 30.6 2.6 1 1 1 2 2 2 1 Interferon-induced 6-16 family Cerato-platanin PF07249.12 KOS23118.1 - 4.5e-50 168.7 2.0 5.3e-50 168.5 2.0 1.1 1 0 0 1 1 1 1 Cerato-platanin RHS_repeat PF05593.14 KOS23118.1 - 0.026 15.1 0.1 0.089 13.3 0.1 1.9 1 0 0 1 1 1 0 RHS Repeat Cpn60_TCP1 PF00118.24 KOS23119.1 - 1.5e-157 525.2 6.2 1.7e-157 525.0 6.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Enolase_N PF03952.16 KOS23119.1 - 0.18 12.0 1.1 15 5.7 0.1 3.1 3 0 0 3 3 3 0 Enolase, N-terminal domain GTP_EFTU PF00009.27 KOS23120.1 - 2.4e-48 164.3 0.0 4.3e-48 163.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HET PF06985.11 KOS23120.1 - 8.7e-30 104.0 0.1 8.7e-30 104.0 0.1 2.3 2 0 0 2 2 2 1 Heterokaryon incompatibility protein (HET) HBS1_N PF08938.10 KOS23120.1 - 1.6e-21 76.4 0.1 1.6e-21 76.4 0.1 2.9 3 0 0 3 3 3 1 HBS1 N-terminus MMR_HSR1 PF01926.23 KOS23120.1 - 3e-07 30.5 0.0 5.5e-06 26.4 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 KOS23120.1 - 1.9e-05 25.0 0.1 5.2e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 KOS23120.1 - 0.00025 21.3 0.0 0.00083 19.6 0.0 1.8 2 0 0 2 2 1 1 Elongation factor Tu C-terminal domain Roc PF08477.13 KOS23120.1 - 0.0091 16.2 0.1 0.67 10.2 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 KOS23120.1 - 0.038 13.3 0.0 0.068 12.4 0.0 1.4 1 0 0 1 1 1 0 Septin Dynamin_N PF00350.23 KOS23120.1 - 0.059 13.4 3.6 9.4 6.3 0.0 3.5 3 1 1 4 4 4 0 Dynamin family SRPRB PF09439.10 KOS23120.1 - 0.11 11.9 0.2 4.7 6.6 0.1 2.9 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_22 PF13401.6 KOS23120.1 - 0.14 12.5 0.0 0.73 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain Peptidase_S24 PF00717.23 KOS23120.1 - 0.15 12.0 0.0 2.4 8.2 0.0 2.5 2 0 0 2 2 2 0 Peptidase S24-like Rhabdo_ncap PF00945.18 KOS23120.1 - 0.91 8.3 2.5 1.7 7.4 2.5 1.3 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein BSP_II PF05432.11 KOS23120.1 - 1.7 8.2 16.1 0.023 14.4 3.4 2.8 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) FAM176 PF14851.6 KOS23120.1 - 6.1 6.5 10.8 0.51 10.0 3.1 2.9 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.14 KOS23120.1 - 8.1 4.6 7.6 4.5 5.4 5.1 1.7 2 0 0 2 2 2 0 CDC45-like protein Glyoxalase PF00903.25 KOS23121.1 - 1.1e-37 129.1 0.2 3.9e-18 65.9 0.1 2.2 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 KOS23121.1 - 8.2e-17 61.5 0.0 3.4e-07 30.5 0.0 3.2 2 2 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 KOS23121.1 - 2.4e-11 44.3 0.0 3.2e-06 27.9 0.0 2.8 2 2 0 2 2 2 2 Glyoxalase-like domain Glyoxalase_3 PF13468.6 KOS23121.1 - 3.6e-09 37.0 0.3 0.0031 17.6 0.0 2.9 1 1 3 4 4 4 4 Glyoxalase-like domain Glyoxalase_2 PF12681.7 KOS23121.1 - 0.00051 20.0 0.0 2.3 8.2 0.0 3.8 4 0 0 4 4 4 2 Glyoxalase-like domain GATase_6 PF13522.6 KOS23122.1 - 1.7e-12 47.6 0.0 4.5e-12 46.3 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 KOS23122.1 - 3.9e-09 36.5 0.0 7.3e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 KOS23122.1 - 9.1e-07 28.5 0.1 2.2e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Fe_hyd_lg_C PF02906.14 KOS23122.1 - 0.015 15.0 0.0 0.51 10.0 0.0 2.2 2 0 0 2 2 2 0 Iron only hydrogenase large subunit, C-terminal domain PA PF02225.22 KOS23122.1 - 0.13 12.3 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 PA domain KCH PF16944.5 KOS23123.1 - 3.6e-100 334.9 7.8 4.2e-100 334.7 7.8 1.0 1 0 0 1 1 1 1 Fungal potassium channel DUF3440 PF11922.8 KOS23123.1 - 0.071 12.8 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) Cwf_Cwc_15 PF04889.12 KOS23124.1 - 1.5 8.5 5.7 2.4 7.8 5.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ATP-grasp_2 PF08442.10 KOS23125.1 - 4.2e-77 258.3 1.1 4.2e-77 258.3 1.1 1.5 2 0 0 2 2 2 1 ATP-grasp domain Ligase_CoA PF00549.19 KOS23125.1 - 3.7e-26 91.8 0.5 8.8e-26 90.6 0.5 1.7 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 KOS23125.1 - 6.4e-07 29.0 0.2 1.2e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 KOS23125.1 - 0.0017 18.2 1.0 0.022 14.5 0.2 2.5 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain OKR_DC_1_N PF03709.15 KOS23125.1 - 0.047 14.0 0.2 0.42 10.9 0.1 2.6 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Peripla_BP_2 PF01497.18 KOS23125.1 - 0.11 12.1 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 Periplasmic binding protein Methyltransf_11 PF08241.12 KOS23126.1 - 2.8e-05 24.7 0.0 9.9e-05 22.9 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS23126.1 - 4.6e-05 24.0 0.0 0.00012 22.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Complex1_30kDa PF00329.19 KOS23127.1 - 2.6e-41 141.0 0.0 3.6e-41 140.6 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CTP_transf_3 PF02348.19 KOS23127.1 - 0.065 13.1 0.1 0.097 12.6 0.1 1.1 1 0 0 1 1 1 0 Cytidylyltransferase DUF4686 PF15742.5 KOS23128.1 - 0.18 10.9 34.3 0.06 12.5 16.1 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4686) HMMR_N PF15905.5 KOS23128.1 - 2.5 7.5 36.4 0.36 10.3 18.0 2.7 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF2570 PF10828.8 KOS23128.1 - 8.7 6.2 16.8 0.11 12.3 3.8 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF2570) E1_dh PF00676.20 KOS23129.1 - 2.7e-87 292.5 0.0 3.2e-87 292.3 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 KOS23129.1 - 6.6e-05 22.7 0.1 0.001 18.9 0.0 2.4 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DXP_synthase_N PF13292.6 KOS23129.1 - 0.04 13.1 0.0 0.1 11.8 0.0 1.6 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase SGS PF05002.15 KOS23129.1 - 0.33 11.1 2.3 0.71 10.0 0.9 2.1 2 0 0 2 2 2 0 SGS domain Ubie_methyltran PF01209.18 KOS23130.1 - 3.4e-78 262.2 0.0 4.1e-78 261.9 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 KOS23130.1 - 8.1e-16 58.5 0.0 2.4e-15 57.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 KOS23130.1 - 4.4e-13 49.7 0.0 3.2e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 KOS23130.1 - 6.7e-11 42.8 0.0 9.9e-11 42.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 KOS23130.1 - 1.9e-10 40.7 0.0 2.7e-10 40.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 KOS23130.1 - 1.8e-08 34.4 0.0 2.4e-08 34.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 KOS23130.1 - 0.021 14.7 0.0 0.12 12.2 0.0 2.1 3 0 0 3 3 3 0 Hypothetical methyltransferase SOG2 PF10428.9 KOS23131.1 - 0.022 14.0 11.5 0.025 13.8 11.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein ORC6 PF05460.13 KOS23131.1 - 0.2 10.9 6.7 0.26 10.5 6.7 1.3 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) HEAT PF02985.22 KOS23132.1 - 0.00091 19.3 0.3 0.083 13.2 0.0 3.5 4 0 0 4 4 4 1 HEAT repeat Arm PF00514.23 KOS23132.1 - 0.0098 15.9 0.9 0.73 10.0 0.1 3.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Complex1_51K PF01512.17 KOS23133.1 - 2.8e-48 163.6 0.0 4.7e-48 162.9 0.0 1.4 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 KOS23133.1 - 2.1e-29 101.4 1.6 2.9e-29 101.0 0.2 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 KOS23133.1 - 4.1e-09 36.2 0.0 9.3e-09 35.0 0.0 1.7 1 0 0 1 1 1 1 SLBB domain Sec3_C PF09763.9 KOS23134.1 - 1.2e-202 675.1 2.4 6.1e-113 378.6 0.3 2.0 1 1 1 2 2 2 2 Exocyst complex component Sec3 Sec3_C_2 PF15278.6 KOS23134.1 - 0.00088 19.6 3.3 0.023 15.0 0.0 3.6 4 0 0 4 4 4 1 Sec3 exocyst complex subunit MIF4G PF02854.19 KOS23134.1 - 0.039 13.6 0.5 0.24 11.0 0.1 2.4 3 0 0 3 3 3 0 MIF4G domain TetR_C_8 PF14278.6 KOS23134.1 - 0.71 10.0 5.4 0.19 11.9 0.7 2.5 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region Sclerostin PF05463.11 KOS23135.1 - 0.022 14.5 0.0 0.025 14.3 0.0 1.1 1 0 0 1 1 1 0 Sclerostin (SOST) Acetyltransf_1 PF00583.25 KOS23136.1 - 1.2e-11 44.8 0.0 2.1e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 KOS23136.1 - 1.1e-07 31.8 0.1 1.8e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 KOS23136.1 - 1.2e-06 28.4 0.1 2.3e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.7 KOS23136.1 - 2.4e-05 24.7 0.0 4.6e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 KOS23136.1 - 0.02 15.0 0.1 0.037 14.1 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Herpes_UL47 PF03362.13 KOS23136.1 - 0.061 12.1 0.0 0.083 11.7 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL47 protein Paf1 PF03985.13 KOS23136.1 - 2.7 6.9 7.6 3.3 6.6 7.6 1.2 1 0 0 1 1 1 0 Paf1 NIF PF03031.18 KOS23137.1 - 2e-41 141.4 0.0 2.9e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase NOA36 PF06524.12 KOS23137.1 - 0.55 9.5 2.9 1.1 8.6 2.9 1.4 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 KOS23137.1 - 4.8 6.7 5.8 0.94 9.0 0.1 2.0 2 0 0 2 2 2 0 PPP4R2 IF-2B PF01008.17 KOS23138.1 - 4e-45 154.2 0.0 1.1e-44 152.7 0.0 1.6 1 1 0 1 1 1 1 Initiation factor 2 subunit family Ribosomal_L7Ae PF01248.26 KOS23139.1 - 1.2e-21 76.2 0.5 5.7e-21 74.1 0.5 2.1 1 1 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FAM91_C PF14648.6 KOS23139.1 - 0.0052 15.7 1.0 0.0065 15.4 1.0 1.1 1 0 0 1 1 1 1 FAM91 C-terminus Zip PF02535.22 KOS23139.1 - 0.39 9.9 1.5 0.34 10.1 1.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pox_Ag35 PF03286.14 KOS23139.1 - 2.1 8.1 0.0 2.1 8.1 0.0 2.4 2 1 0 2 2 2 0 Pox virus Ag35 surface protein FAM60A PF15396.6 KOS23139.1 - 4.4 7.2 13.5 0.55 10.2 8.9 1.7 2 0 0 2 2 2 0 Protein Family FAM60A DUF4050 PF13259.6 KOS23139.1 - 5.9 7.2 9.7 1.5 9.1 6.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) CLN3 PF02487.17 KOS23139.1 - 7.8 5.4 4.7 13 4.8 4.7 1.3 1 0 0 1 1 1 0 CLN3 protein DUF1761 PF08570.10 KOS23140.1 - 8.3e-26 90.7 1.1 9.4e-26 90.5 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1761) Band_7 PF01145.25 KOS23141.1 - 1.6e-23 83.6 6.9 3.3e-23 82.6 6.9 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 KOS23141.1 - 0.00064 18.9 6.0 0.00084 18.5 6.0 1.1 1 0 0 1 1 1 1 SigmaW regulon antibacterial DUF3103 PF11301.8 KOS23141.1 - 0.011 14.6 0.2 0.018 13.9 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) GatB_Yqey PF02637.18 KOS23141.1 - 0.092 12.6 1.7 0.17 11.8 1.6 1.5 1 1 0 1 1 1 0 GatB domain PknG_rubred PF16919.5 KOS23141.1 - 0.16 12.1 0.2 0.28 11.3 0.2 1.3 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain UcrQ PF02939.16 KOS23142.1 - 6.7e-37 125.3 0.3 7.8e-37 125.1 0.3 1.0 1 0 0 1 1 1 1 UcrQ family PRELI PF04707.14 KOS23143.1 - 1.6e-18 67.0 0.0 2.6e-16 59.8 0.0 2.1 2 0 0 2 2 2 2 PRELI-like family DUF676 PF05057.14 KOS23144.1 - 2.2e-24 86.2 0.0 2.7e-12 46.7 0.0 2.1 2 0 0 2 2 2 2 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 KOS23144.1 - 0.018 15.7 0.0 0.036 14.7 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family PGAP1 PF07819.13 KOS23144.1 - 0.061 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Thioesterase PF00975.20 KOS23144.1 - 0.085 13.0 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain DUF4407 PF14362.6 KOS23145.1 - 0.00062 19.2 4.2 0.00075 18.9 4.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) RCDG1 PF15725.5 KOS23145.1 - 0.57 10.6 10.9 0.79 10.2 0.3 2.5 2 0 0 2 2 2 0 Renal cancer differentiation gene 1 protein MscS_porin PF12795.7 KOS23145.1 - 3.4 7.2 11.1 0.092 12.3 4.1 1.9 3 0 0 3 3 3 0 Mechanosensitive ion channel porin domain RTA1 PF04479.13 KOS23146.1 - 5e-70 235.3 3.4 6.7e-70 234.9 3.4 1.2 1 0 0 1 1 1 1 RTA1 like protein Adaptin_N PF01602.20 KOS23147.1 - 3.6e-96 322.8 0.1 4.5e-96 322.5 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 KOS23147.1 - 5.3e-16 59.1 0.1 1.1e-14 54.8 0.0 2.6 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 KOS23147.1 - 2.1e-10 40.8 5.9 0.00022 21.6 0.1 5.3 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 KOS23147.1 - 9.6e-08 31.7 3.9 0.056 13.7 0.0 5.4 6 0 0 6 6 4 2 HEAT repeat Cohesin_HEAT PF12765.7 KOS23147.1 - 6.9e-07 29.5 1.5 0.0045 17.3 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat associated with sister chromatid cohesion HEAT_EZ PF13513.6 KOS23147.1 - 0.00033 21.1 1.0 0.53 10.8 0.1 4.4 4 0 0 4 4 3 1 HEAT-like repeat CLASP_N PF12348.8 KOS23147.1 - 0.026 14.1 0.4 4.8 6.7 0.0 3.1 2 1 1 3 3 3 0 CLASP N terminal VIR_N PF15912.5 KOS23147.1 - 0.045 13.4 3.3 0.084 12.5 3.3 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal SDA1 PF05285.12 KOS23147.1 - 0.075 12.5 15.6 0.11 11.9 15.6 1.2 1 0 0 1 1 1 0 SDA1 RTP1_C1 PF10363.9 KOS23147.1 - 0.15 12.2 0.3 4.8 7.4 0.0 3.3 3 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Nop14 PF04147.12 KOS23147.1 - 0.62 8.2 22.8 0.99 7.5 22.8 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 KOS23147.1 - 3.3 6.9 16.1 4.8 6.4 16.1 1.2 1 0 0 1 1 1 0 BUD22 RNA_pol_3_Rpc31 PF11705.8 KOS23147.1 - 4.2 7.6 27.2 5.1 7.3 25.2 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 RR_TM4-6 PF06459.12 KOS23147.1 - 6.2 6.6 9.2 10 5.8 9.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-C2H2 PF00096.26 KOS23148.1 - 2.6e-07 30.7 12.4 0.013 15.9 0.9 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 KOS23148.1 - 0.0028 18.4 10.2 1.5 9.8 0.6 3.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_aberr PF17017.5 KOS23148.1 - 0.0064 16.7 3.6 0.15 12.2 0.1 2.3 1 1 1 2 2 2 1 Aberrant zinc-finger DUF3450 PF11932.8 KOS23148.1 - 0.027 13.8 3.1 0.039 13.3 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) ZapB PF06005.12 KOS23148.1 - 0.048 14.1 6.1 0.11 13.0 6.1 1.5 1 0 0 1 1 1 0 Cell division protein ZapB GAS PF13851.6 KOS23148.1 - 0.11 11.9 7.8 0.18 11.2 7.8 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 KOS23148.1 - 0.38 10.9 5.2 0.57 10.2 5.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SHE3 PF17078.5 KOS23148.1 - 3.7 7.2 9.5 5.7 6.6 9.5 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 zf-H2C2_5 PF13909.6 KOS23148.1 - 8.7 6.2 8.5 0.67 9.8 0.5 3.0 3 0 0 3 3 3 0 C2H2-type zinc-finger domain FCH PF00611.23 KOS23149.1 - 3.6e-24 84.8 2.6 1.2e-23 83.1 0.0 2.5 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 KOS23149.1 - 1.7e-20 72.6 0.6 2.2e-10 40.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain C1_1 PF00130.22 KOS23149.1 - 5.7e-15 54.9 5.2 9.5e-15 54.2 5.2 1.4 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 PF00018.28 KOS23149.1 - 2.1e-14 52.9 0.2 4.5e-07 29.4 0.1 2.4 2 0 0 2 2 2 2 SH3 domain SH3_3 PF08239.11 KOS23149.1 - 0.0003 21.0 0.8 0.0016 18.7 0.4 2.2 2 0 0 2 2 2 1 Bacterial SH3 domain SH3_10 PF17902.1 KOS23149.1 - 0.002 18.1 0.0 0.22 11.6 0.0 2.7 2 0 0 2 2 2 1 SH3 domain C1_2 PF03107.16 KOS23149.1 - 0.0094 16.3 4.8 0.017 15.4 4.8 1.4 1 0 0 1 1 1 1 C1 domain FYVE PF01363.21 KOS23149.1 - 0.077 13.2 1.9 0.16 12.1 1.9 1.4 1 0 0 1 1 1 0 FYVE zinc finger Glyco_hydro_9 PF00759.19 KOS23149.1 - 0.51 9.7 10.6 0.067 12.6 0.6 2.2 2 0 0 2 2 2 0 Glycosyl hydrolase family 9 DUF4337 PF14235.6 KOS23149.1 - 4.5 7.4 6.5 1.2 9.3 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) LysM PF01476.20 KOS23150.1 - 4.1e-28 97.2 1.9 1.3e-07 31.5 0.0 5.3 5 0 0 5 5 5 4 LysM domain BrkDBD PF09607.10 KOS23150.1 - 0.00065 19.4 0.1 0.23 11.3 0.1 2.5 2 0 0 2 2 2 2 Brinker DNA-binding domain DUF5419 PF17441.2 KOS23150.1 - 0.018 15.1 2.2 34 4.7 0.1 4.0 4 0 0 4 4 4 0 Family of unknown function (DUF5419) HTH_28 PF13518.6 KOS23150.1 - 0.025 14.7 0.1 9 6.5 0.0 2.7 2 0 0 2 2 2 0 Helix-turn-helix domain Herpes_TK_C PF08465.10 KOS23150.1 - 0.25 11.1 2.4 8.8 6.2 0.1 2.5 2 0 0 2 2 2 0 Thymidine kinase from Herpesvirus C-terminal FAD_binding_4 PF01565.23 KOS23151.1 - 2e-26 92.4 0.8 3.3e-26 91.7 0.8 1.4 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 KOS23151.1 - 5.7e-05 23.1 0.3 0.00011 22.2 0.3 1.5 1 0 0 1 1 1 1 Berberine and berberine like Cas9_a PF18470.1 KOS23151.1 - 0.2 11.2 0.1 0.41 10.1 0.0 1.5 2 0 0 2 2 2 0 Cas9 alpha-helical lobe domain Ribosomal_60s PF00428.19 KOS23152.1 - 8.8e-28 96.7 14.8 1.1e-27 96.5 14.8 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_holin_6_1 PF09682.10 KOS23152.1 - 0.2 12.1 4.1 0.58 10.6 0.5 2.0 1 1 1 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) Cytomega_UL84 PF06284.11 KOS23152.1 - 0.22 10.0 0.8 0.27 9.6 0.8 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3824 PF12868.7 KOS23152.1 - 4.8 7.8 4.8 7 7.3 4.8 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Cation_ATPase_C PF00689.21 KOS23153.1 - 1.6e-41 142.0 3.4 1.6e-41 142.0 3.4 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOS23153.1 - 2.6e-34 118.3 0.9 2.6e-34 118.3 0.9 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOS23153.1 - 3e-23 81.7 0.0 6.4e-23 80.7 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOS23153.1 - 6.4e-21 75.6 0.0 1.5e-20 74.4 0.0 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOS23153.1 - 9.3e-07 28.4 0.1 9.6e-06 25.2 0.0 2.4 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS23153.1 - 2.5e-05 24.1 1.2 0.00013 21.8 0.7 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 KOS23153.1 - 0.005 17.3 0.0 0.01 16.3 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF4231 PF14015.6 KOS23153.1 - 9 6.8 7.0 70 4.0 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) TTL PF03133.15 KOS23154.1 - 2.3e-54 184.5 0.0 1.4e-53 182.0 0.0 1.9 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 KOS23154.1 - 8.2e-50 169.3 0.0 1.1e-49 168.8 0.0 1.2 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 KOS23154.1 - 8.1e-05 22.0 0.0 0.00019 20.8 0.0 1.5 1 0 0 1 1 1 1 YheC/D like ATP-grasp Peptidase_S8 PF00082.22 KOS23155.1 - 7.6e-12 45.1 0.0 1.6e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Subtilase family Ank_4 PF13637.6 KOS23155.1 - 9.2e-08 32.5 0.0 0.0087 16.6 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS23155.1 - 1.6e-07 31.8 0.2 0.0052 17.3 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 KOS23155.1 - 0.00022 21.5 0.0 0.03 14.8 0.0 3.5 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 KOS23155.1 - 0.00091 19.5 0.0 2.2 9.1 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 KOS23155.1 - 0.02 15.2 0.1 0.69 10.3 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) FAD_binding_3 PF01494.19 KOS23156.1 - 1.2e-19 70.7 0.6 2e-19 70.1 0.6 1.4 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 KOS23156.1 - 1.5e-09 37.9 7.0 0.00021 21.0 0.3 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS23156.1 - 1.1e-08 34.7 0.1 5.2e-05 22.6 0.1 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 KOS23156.1 - 4.2e-08 32.5 0.2 0.0037 16.2 0.0 2.4 2 0 0 2 2 2 2 Tryptophan halogenase NAD_binding_8 PF13450.6 KOS23156.1 - 6.1e-08 32.8 0.5 1.7e-07 31.4 0.5 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOS23156.1 - 1.5e-07 30.5 0.5 7.5e-07 28.2 0.7 2.0 2 1 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 KOS23156.1 - 3.4e-07 29.7 2.7 3.5e-06 26.4 0.8 2.1 1 1 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 KOS23156.1 - 6.8e-07 29.0 0.7 9.1e-07 28.6 0.7 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 KOS23156.1 - 3e-06 27.7 0.0 0.001 19.6 0.1 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 KOS23156.1 - 1e-05 25.0 0.1 0.053 12.8 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 KOS23156.1 - 0.0001 21.5 5.1 0.0014 17.8 1.5 3.0 2 1 0 2 2 2 1 Lycopene cyclase protein NAD_binding_9 PF13454.6 KOS23156.1 - 0.00028 20.9 1.8 0.14 12.1 0.1 2.5 2 0 0 2 2 2 2 FAD-NAD(P)-binding GIDA PF01134.22 KOS23156.1 - 0.00044 19.5 0.3 0.00074 18.7 0.1 1.5 2 0 0 2 2 2 1 Glucose inhibited division protein A Thi4 PF01946.17 KOS23156.1 - 0.0041 16.4 0.4 0.0082 15.4 0.4 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 KOS23156.1 - 0.012 14.9 0.0 0.1 11.8 0.0 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase SE PF08491.10 KOS23156.1 - 0.02 14.0 0.0 0.12 11.4 0.0 1.9 2 0 0 2 2 2 0 Squalene epoxidase ApbA PF02558.16 KOS23156.1 - 0.068 12.8 0.6 0.12 12.0 0.6 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Abhydrolase_3 PF07859.13 KOS23157.1 - 3.5e-34 118.5 0.1 6.6e-34 117.6 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 KOS23157.1 - 0.00057 19.2 0.1 0.02 14.1 0.1 2.3 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Say1_Mug180 PF10340.9 KOS23157.1 - 0.0022 16.9 0.0 0.012 14.5 0.0 1.8 1 1 0 1 1 1 1 Steryl acetyl hydrolase Thioesterase PF00975.20 KOS23157.1 - 0.046 13.8 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_1 PF00561.20 KOS23157.1 - 0.11 12.2 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold U-box PF04564.15 KOS23158.1 - 1.1e-18 67.2 0.0 1.8e-18 66.5 0.0 1.4 1 0 0 1 1 1 1 U-box domain TPR_1 PF00515.28 KOS23158.1 - 4.5e-10 38.9 5.6 0.021 14.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 KOS23158.1 - 8.8e-10 37.9 8.4 0.00036 20.4 0.3 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 KOS23158.1 - 1.2e-08 34.4 2.6 2e-06 27.4 0.2 2.8 2 1 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 KOS23158.1 - 4.3e-08 33.0 5.7 0.0015 18.8 0.5 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 KOS23158.1 - 5.8e-06 26.9 8.6 0.00012 22.6 0.7 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 KOS23158.1 - 6e-06 26.7 5.3 0.0036 17.8 0.2 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 KOS23158.1 - 0.00016 21.8 4.2 0.0004 20.5 0.4 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS23158.1 - 0.00068 19.5 1.5 2.2 8.5 0.0 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 KOS23158.1 - 0.0022 18.7 2.6 0.0041 17.8 2.6 1.4 1 0 0 1 1 1 1 CHIP N-terminal tetratricopeptide repeat domain TPR_8 PF13181.6 KOS23158.1 - 0.0037 17.4 1.6 0.38 11.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS23158.1 - 0.011 16.5 0.1 0.011 16.5 0.1 5.0 4 1 2 6 6 6 0 Tetratricopeptide repeat zf-NOSIP PF15906.5 KOS23158.1 - 0.07 13.3 0.0 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_12 PF13424.6 KOS23158.1 - 0.98 9.8 16.9 2.2 8.6 0.4 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 KOS23158.1 - 5 7.1 7.8 4.3 7.4 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Mg_trans_NIPA PF05653.14 KOS23159.1 - 2.3e-92 309.3 26.2 3e-92 308.9 26.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 KOS23159.1 - 5.3e-06 26.7 7.2 5.3e-06 26.7 7.2 3.3 3 0 0 3 3 3 2 EamA-like transporter family DUF805 PF05656.14 KOS23159.1 - 0.28 11.6 11.4 0.89 10.0 3.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF805) SLC35F PF06027.12 KOS23159.1 - 1.1 8.7 17.7 1.9 7.9 17.5 1.4 1 1 0 1 1 1 0 Solute carrier family 35 DUF4131 PF13567.6 KOS23159.1 - 2.3 7.9 4.3 5.9 6.5 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) DHO_dh PF01180.21 KOS23160.1 - 1.2e-62 211.8 0.0 1.7e-62 211.3 0.0 1.2 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase PcrB PF01884.17 KOS23160.1 - 0.022 14.2 1.7 3.3 7.1 0.0 2.6 3 0 0 3 3 3 0 PcrB family DUF4907 PF16250.5 KOS23160.1 - 0.045 13.6 0.0 0.081 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4907) FMN_dh PF01070.18 KOS23160.1 - 0.82 8.6 7.6 0.019 14.0 0.8 1.8 2 0 0 2 2 2 0 FMN-dependent dehydrogenase SBF PF01758.16 KOS23161.1 - 3.4e-50 170.4 12.8 5e-50 169.9 11.1 2.0 2 0 0 2 2 2 1 Sodium Bile acid symporter family Ank_2 PF12796.7 KOS23162.1 - 3.2e-82 271.2 14.1 4.1e-14 52.9 0.3 9.8 3 3 7 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS23162.1 - 9.2e-75 246.1 8.9 2.7e-08 34.2 0.0 14.8 9 5 6 15 15 15 13 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS23162.1 - 3.1e-55 177.6 6.9 0.00043 20.5 0.0 18.4 18 1 0 18 18 18 12 Ankyrin repeat Ank PF00023.30 KOS23162.1 - 1e-54 180.7 20.9 0.0023 18.3 0.0 17.9 18 1 0 18 18 18 12 Ankyrin repeat Ank_5 PF13857.6 KOS23162.1 - 1.3e-45 152.9 22.5 6e-10 39.2 0.2 13.5 9 4 4 13 13 13 10 Ankyrin repeats (many copies) ZZ PF00569.17 KOS23162.1 - 0.0096 15.7 3.3 0.019 14.7 3.3 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type Glyco_transf_25 PF01755.17 KOS23165.1 - 0.0005 20.0 0.0 0.95 9.3 0.0 2.8 3 0 0 3 3 3 2 Glycosyltransferase family 25 (LPS biosynthesis protein) Cellulase PF00150.18 KOS23166.1 - 4.9e-48 164.0 0.1 6.8e-48 163.5 0.1 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) CBM_1 PF00734.18 KOS23166.1 - 4.4e-28 96.9 27.7 9.3e-14 51.1 12.6 3.2 2 0 0 2 2 2 2 Fungal cellulose binding domain FAD_binding_4 PF01565.23 KOS23167.1 - 2.1e-11 43.7 2.9 2.1e-11 43.7 2.9 2.0 3 0 0 3 3 3 1 FAD binding domain Rif1_N PF12231.8 KOS23167.1 - 0.16 10.9 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 Rap1-interacting factor 1 N terminal Ank_4 PF13637.6 KOS23169.1 - 1.6e-14 54.1 0.9 2.1e-07 31.4 0.1 4.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 KOS23169.1 - 4.2e-12 46.5 0.1 0.00051 20.6 0.0 3.4 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 KOS23169.1 - 1.9e-11 43.1 0.4 0.00055 20.2 0.0 4.9 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 KOS23169.1 - 6.7e-11 42.1 1.7 0.0014 19.0 0.0 4.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 KOS23169.1 - 4e-07 30.2 0.3 0.041 14.2 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) KilA-N PF04383.13 KOS23169.1 - 0.00011 22.1 0.4 0.00079 19.2 0.2 2.3 2 1 0 2 2 2 1 KilA-N domain Golgin_A5 PF09787.9 KOS23169.1 - 0.1 12.0 5.7 0.17 11.3 5.7 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Med2 PF11214.8 KOS23169.1 - 0.19 11.9 0.7 0.38 10.9 0.7 1.4 1 0 0 1 1 1 0 Mediator complex subunit 2 4HB_MCP_1 PF12729.7 KOS23169.1 - 0.42 10.2 3.1 0.69 9.4 3.1 1.2 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Macoilin PF09726.9 KOS23169.1 - 6.7 5.1 7.9 9.6 4.6 7.9 1.1 1 0 0 1 1 1 0 Macoilin family FYVE PF01363.21 KOS23170.1 - 4.4e-24 84.4 17.5 3.1e-17 62.5 5.8 3.0 3 0 0 3 3 3 2 FYVE zinc finger Rbsn PF11464.8 KOS23170.1 - 1.3e-17 63.2 0.5 2.7e-17 62.2 0.5 1.6 1 0 0 1 1 1 1 Rabenosyn Rab binding domain zf-Di19 PF05605.12 KOS23170.1 - 0.00049 20.3 6.5 0.014 15.7 0.0 2.8 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.16 KOS23170.1 - 0.0016 18.6 1.4 0.0016 18.6 1.4 3.9 3 1 1 4 4 4 1 AN1-like Zinc finger FliJ PF02050.16 KOS23170.1 - 0.15 12.3 2.1 8.6 6.6 0.9 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein ABC_tran_CTD PF16326.5 KOS23170.1 - 0.22 11.8 3.9 1.1 9.6 1.2 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain Lzipper-MIP1 PF14389.6 KOS23170.1 - 0.6 10.4 4.0 16 5.9 0.5 2.9 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 bZIP_1 PF00170.21 KOS23170.1 - 0.62 10.2 9.5 0.85 9.8 0.0 3.5 3 0 0 3 3 3 0 bZIP transcription factor TMF_DNA_bd PF12329.8 KOS23170.1 - 0.97 9.5 4.6 34 4.5 0.0 3.3 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.8 KOS23170.1 - 2.5 8.3 11.3 0.25 11.6 4.4 2.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding zf-CRD PF17979.1 KOS23170.1 - 3.1 7.9 8.7 2.5 8.2 2.0 2.7 2 0 0 2 2 2 0 Cysteine rich domain with multizinc binding regions zinc_ribbon_9 PF14369.6 KOS23170.1 - 8.5 6.7 14.1 2.3 8.6 0.2 3.9 5 0 0 5 5 5 0 zinc-ribbon TPK_catalytic PF04263.16 KOS23171.1 - 4e-29 101.1 0.0 7e-29 100.3 0.0 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 KOS23171.1 - 7.2e-25 86.5 0.1 1.2e-24 85.8 0.1 1.4 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain DUF2112 PF09885.9 KOS23171.1 - 0.087 12.9 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2112) V-SNARE_C PF12352.8 KOS23172.1 - 1.8e-12 47.3 0.1 3.7e-12 46.3 0.1 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 KOS23172.1 - 0.00018 21.4 0.0 0.0004 20.2 0.0 1.5 1 0 0 1 1 1 1 Sec20 TPR_MLP1_2 PF07926.12 KOS23172.1 - 0.25 11.4 1.3 2.8 8.0 0.3 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein NAD_binding_7 PF13241.6 KOS23173.1 - 1.4e-29 102.6 0.1 2.2e-29 101.9 0.1 1.3 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 KOS23173.1 - 7.8e-27 92.7 0.0 1.2e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 KOS23173.1 - 1.7e-10 40.1 0.1 2.9e-10 39.4 0.1 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox_3 PF13738.6 KOS23173.1 - 0.016 14.5 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 KOS23173.1 - 0.061 13.6 0.2 0.14 12.4 0.2 1.6 1 1 0 1 1 1 0 TrkA-N domain Importin_rep_4 PF18808.1 KOS23173.1 - 0.19 12.1 0.7 0.36 11.1 0.7 1.4 1 0 0 1 1 1 0 Importin repeat CHCH PF06747.13 KOS23174.1 - 6.3e-07 29.4 5.5 1e-06 28.7 5.5 1.3 1 0 0 1 1 1 1 CHCH domain ATP-synt_E PF05680.12 KOS23174.1 - 0.16 12.3 2.0 0.31 11.4 0.9 2.0 1 1 0 1 1 1 0 ATP synthase E chain PTR2 PF00854.21 KOS23175.1 - 3.2e-77 260.0 3.9 6.5e-77 259.0 3.9 1.4 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 KOS23175.1 - 0.00016 20.7 24.8 0.0007 18.6 23.1 2.5 2 1 0 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 KOS23176.1 - 3.1e-05 23.1 6.7 3.1e-05 23.1 6.7 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily MFS_1 PF07690.16 KOS23177.1 - 1.6e-51 175.3 23.5 1.6e-51 175.3 23.5 2.0 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS23177.1 - 1.8e-11 43.6 11.0 1.8e-11 43.6 11.0 3.1 3 0 0 3 3 3 1 Sugar (and other) transporter TRI12 PF06609.13 KOS23177.1 - 4.8e-07 28.6 4.5 7.5e-07 27.9 4.5 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 KOS23177.1 - 0.0023 16.4 3.4 0.0023 16.4 3.4 1.9 3 0 0 3 3 3 1 Transmembrane secretion effector U3_snoRNA_assoc PF08297.11 KOS23177.1 - 0.0073 17.0 0.1 0.012 16.3 0.1 1.3 1 0 0 1 1 1 1 U3 snoRNA associated MFS_1_like PF12832.7 KOS23177.1 - 0.0081 15.1 7.9 0.017 14.0 4.0 2.7 2 1 1 3 3 3 2 MFS_1 like family MFS_5 PF05631.14 KOS23177.1 - 0.021 13.7 2.7 0.04 12.8 2.7 1.4 1 0 0 1 1 1 0 Sugar-tranasporters, 12 TM CshA_NR2 PF18651.1 KOS23177.1 - 0.12 11.5 0.1 0.19 10.9 0.1 1.1 1 0 0 1 1 1 0 Surface adhesin CshA non-repetitive domain 2 ATG22 PF11700.8 KOS23177.1 - 0.13 10.9 10.0 0.54 8.8 0.1 2.6 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like OATP PF03137.20 KOS23177.1 - 0.42 8.8 10.8 0.012 13.9 1.9 2.7 3 1 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family LRR19-TM PF15176.6 KOS23177.1 - 0.55 10.3 1.6 1.2 9.2 0.0 2.4 3 0 0 3 3 2 0 Leucine-rich repeat family 19 TM domain p450 PF00067.22 KOS23178.1 - 7.3e-51 173.3 0.0 1.7e-50 172.2 0.0 1.4 1 1 0 1 1 1 1 Cytochrome P450 TonB_N PF16031.5 KOS23178.1 - 0.18 12.3 5.5 0.35 11.4 5.5 1.3 1 0 0 1 1 1 0 TonB polyproline region Glutaredoxin PF00462.24 KOS23179.1 - 2e-16 59.9 0.0 3.5e-16 59.2 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Glyco_hydro_3_C PF01915.22 KOS23180.1 - 2e-50 171.6 0.0 2.9e-50 171.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS23180.1 - 2e-37 129.3 0.1 4.2e-27 95.4 0.1 2.6 2 1 1 3 3 3 2 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS23180.1 - 7.2e-14 51.6 0.1 1.5e-13 50.7 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain PA14 PF07691.12 KOS23180.1 - 3.9e-07 30.0 0.0 1e-06 28.7 0.0 1.7 1 0 0 1 1 1 1 PA14 domain ADH_zinc_N_2 PF13602.6 KOS23181.1 - 5.4e-25 89.0 0.0 1e-24 88.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 KOS23181.1 - 1.4e-13 51.0 0.1 1e-12 48.1 0.1 2.2 1 1 1 2 2 2 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOS23181.1 - 1.4e-09 37.8 0.8 3.2e-08 33.4 0.0 2.8 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain Cpn10 PF00166.21 KOS23181.1 - 0.1 12.6 0.5 3.6 7.7 0.2 2.4 2 0 0 2 2 2 0 Chaperonin 10 Kd subunit DOT1 PF08123.13 KOS23181.1 - 0.21 11.1 1.4 0.71 9.4 1.0 1.7 1 1 1 2 2 2 0 Histone methylation protein DOT1 adh_short PF00106.25 KOS23182.1 - 2.8e-32 111.7 0.0 4.6e-15 55.6 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 KOS23182.1 - 7.1e-26 91.2 0.0 5.5e-14 52.3 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 KOS23182.1 - 0.1 12.5 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 KR domain Ank_2 PF12796.7 KOS23183.1 - 4.2e-55 184.3 7.3 2.3e-11 44.1 0.2 7.5 4 2 5 9 9 9 8 Ankyrin repeats (3 copies) Ank_4 PF13637.6 KOS23183.1 - 2.4e-36 123.6 7.7 9.3e-08 32.5 0.0 9.6 4 4 6 10 10 10 8 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS23183.1 - 4.1e-31 103.5 11.0 0.025 15.1 0.0 13.8 14 0 0 14 14 14 7 Ankyrin repeat Ank PF00023.30 KOS23183.1 - 1.7e-26 91.5 13.6 0.0058 17.0 0.0 10.9 11 0 0 11 11 11 6 Ankyrin repeat Ank_5 PF13857.6 KOS23183.1 - 2.4e-23 81.9 16.1 5.6e-05 23.3 0.1 10.7 4 4 8 12 12 12 8 Ankyrin repeats (many copies) PIG-L PF02585.17 KOS23183.1 - 0.19 12.3 0.8 17 6.1 0.0 3.0 3 0 0 3 3 3 0 GlcNAc-PI de-N-acetylase OPT PF03169.15 KOS23184.1 - 3.7e-151 504.8 46.5 4.4e-151 504.6 46.5 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein HPP PF04982.13 KOS23184.1 - 6 7.1 13.8 1.8 8.7 1.3 4.4 4 0 0 4 4 4 0 HPP family ArAE_2_N PF10337.9 KOS23185.1 - 9.4e-91 305.2 1.5 9.4e-91 305.2 1.5 2.6 3 0 0 3 3 3 1 Putative ER transporter, 6TM, N-terminal ArAE_2 PF10334.9 KOS23185.1 - 5.5e-56 190.0 2.4 1.3e-54 185.5 0.1 3.1 4 0 0 4 4 4 1 Aromatic acid exporter family member 2 FUSC_2 PF13515.6 KOS23185.1 - 1.8e-08 34.6 10.8 1.8e-08 34.6 10.8 3.8 3 1 0 3 3 3 1 Fusaric acid resistance protein-like Ubiquitin_3 PF14836.6 KOS23185.1 - 0.026 14.5 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain ALMT PF11744.8 KOS23185.1 - 0.052 12.4 8.6 0.54 9.0 5.7 2.5 1 1 1 2 2 2 0 Aluminium activated malate transporter DUF3740 PF12548.8 KOS23185.1 - 0.096 13.1 0.4 0.19 12.2 0.4 1.4 1 0 0 1 1 1 0 Sulfatase protein Zip PF02535.22 KOS23186.1 - 4.8e-60 203.5 0.3 5.5e-60 203.3 0.3 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2157 PF09925.9 KOS23186.1 - 0.51 10.1 3.7 11 5.7 0.0 3.1 3 1 0 3 3 3 0 Predicted membrane protein (DUF2157) FAD_binding_3 PF01494.19 KOS23187.1 - 3.7e-12 46.2 0.3 1.2e-10 41.2 0.0 2.6 2 1 0 2 2 2 1 FAD binding domain DAO PF01266.24 KOS23187.1 - 0.00045 19.9 0.0 0.018 14.7 0.0 2.5 2 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 KOS23187.1 - 0.00095 18.5 0.1 0.011 15.0 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS23187.1 - 0.02 14.9 0.0 1.5 8.8 0.0 2.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding AlaDh_PNT_C PF01262.21 KOS23187.1 - 0.025 13.9 0.0 0.33 10.2 0.0 2.2 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain B12D PF06522.11 KOS23187.1 - 0.029 14.2 0.0 0.076 12.8 0.0 1.7 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit NAD_binding_8 PF13450.6 KOS23187.1 - 0.032 14.5 0.0 0.28 11.5 0.0 2.6 2 1 1 3 3 3 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 KOS23187.1 - 0.037 13.1 0.2 6.6 5.7 0.0 3.0 3 0 0 3 3 3 0 Lycopene cyclase protein SE PF08491.10 KOS23187.1 - 0.099 11.7 0.0 1.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Squalene epoxidase MIP PF00230.20 KOS23188.1 - 4.8e-40 137.7 13.4 5.4e-40 137.5 13.4 1.0 1 0 0 1 1 1 1 Major intrinsic protein DHHA1 PF02272.19 KOS23189.1 - 0.033 14.6 0.0 0.44 11.0 0.0 2.3 1 1 0 1 1 1 0 DHHA1 domain DHH PF01368.20 KOS23189.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 DHH family ERG4_ERG24 PF01222.17 KOS23190.1 - 4.4e-149 496.9 1.3 4.9e-149 496.7 1.3 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 KOS23190.1 - 0.00049 19.7 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DAO PF01266.24 KOS23191.1 - 6.1e-32 111.6 3.7 7e-32 111.4 3.7 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 KOS23191.1 - 0.0063 15.7 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 KOS23191.1 - 0.0082 15.4 0.2 0.018 14.3 0.2 1.6 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 KOS23191.1 - 0.014 15.6 0.1 0.039 14.2 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 KOS23191.1 - 0.026 15.1 0.4 0.16 12.5 0.1 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Isochorismatase PF00857.20 KOS23191.1 - 0.094 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Isochorismatase family RGS PF00615.19 KOS23192.1 - 1.9e-34 118.5 0.0 7.7e-34 116.5 0.0 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain DEP PF00610.21 KOS23192.1 - 3.7e-23 81.4 0.0 6.1e-19 67.9 0.0 3.3 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) 2-Hacid_dh PF00389.30 KOS23192.1 - 0.051 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Replic_Relax PF13814.6 KOS23192.1 - 0.14 12.2 0.0 0.41 10.7 0.0 1.8 2 0 0 2 2 2 0 Replication-relaxation CDC73_C PF05179.14 KOS23193.1 - 1e-54 184.5 0.0 1.6e-54 183.8 0.0 1.3 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal HAD PF12710.7 KOS23194.1 - 2.4e-24 86.8 0.0 3.1e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 KOS23194.1 - 0.012 15.1 0.0 0.026 14.0 0.0 1.7 1 1 0 1 1 1 0 Pyrimidine 5'-nucleotidase (UMPH-1) She9_MDM33 PF05546.11 KOS23195.1 - 6.5e-81 270.9 4.6 6.5e-81 270.9 4.6 1.6 2 0 0 2 2 2 1 She9 / Mdm33 family DUF1993 PF09351.10 KOS23195.1 - 0.011 15.9 1.0 2.4 8.3 0.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) BCAS2 PF05700.11 KOS23195.1 - 0.013 15.2 7.1 0.16 11.6 2.5 2.5 1 1 1 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) VIR_N PF15912.5 KOS23195.1 - 0.038 13.6 1.2 0.072 12.7 1.2 1.5 1 0 0 1 1 1 0 Virilizer, N-terminal ALG3 PF05208.13 KOS23196.1 - 1e-143 479.2 12.8 1.2e-143 478.9 12.8 1.0 1 0 0 1 1 1 1 ALG3 protein eIF-1a PF01176.19 KOS23197.1 - 2.1e-15 56.3 0.0 2.9e-15 55.8 0.0 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 HR1 PF02185.16 KOS23198.1 - 4.5e-24 84.4 21.4 2.6e-13 49.9 3.5 2.7 3 0 0 3 3 3 2 Hr1 repeat C1_1 PF00130.22 KOS23198.1 - 1.5e-12 47.2 11.2 2.2e-12 46.7 11.2 1.3 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KOS23198.1 - 0.06 13.3 8.2 0.11 12.5 8.2 1.4 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 KOS23198.1 - 0.76 9.8 7.3 1.4 8.9 7.3 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Acyl-CoA_dh_1 PF00441.24 KOS23199.1 - 3.2e-37 128.0 4.8 6.1e-37 127.1 4.8 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 KOS23199.1 - 2.4e-31 108.7 2.2 2.7e-31 108.5 0.2 2.0 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 KOS23199.1 - 4.2e-21 75.0 0.0 8.5e-21 74.0 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 KOS23199.1 - 2.1e-16 60.4 1.6 4.6e-16 59.3 1.6 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 KOS23199.1 - 0.0002 21.1 0.0 0.00062 19.5 0.0 1.8 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal LtrA PF06772.11 KOS23200.1 - 2e-16 60.1 20.8 2e-16 60.1 20.8 2.1 2 0 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) FA_desaturase PF00487.24 KOS23200.1 - 0.0091 15.9 4.0 0.0091 15.9 4.0 3.7 3 1 1 4 4 4 2 Fatty acid desaturase MliC PF09864.9 KOS23201.1 - 0.012 15.6 0.1 0.014 15.3 0.1 1.2 1 0 0 1 1 1 0 Membrane-bound lysozyme-inhibitor of c-type lysozyme Glyco_hydro_3_C PF01915.22 KOS23202.1 - 1.3e-42 146.1 0.0 4.1e-42 144.4 0.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Glyco_hydro_3 PF00933.21 KOS23202.1 - 1.4e-37 129.7 0.0 2.4e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Fn3-like PF14310.6 KOS23202.1 - 1.7e-23 82.5 0.1 3.2e-23 81.6 0.1 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain DUF1746 PF08508.10 KOS23203.1 - 0.017 15.4 0.1 0.033 14.5 0.1 1.4 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) FhuF_C PF11575.8 KOS23203.1 - 0.11 12.4 0.6 2.4 8.2 0.1 3.0 2 0 0 2 2 2 0 FhuF 2Fe-2S C-terminal domain PhnA_Zn_Ribbon PF08274.12 KOS23203.1 - 1.7 8.7 4.7 7.9 6.5 0.1 3.7 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DUF4440 PF14534.6 KOS23204.1 - 3.3e-07 30.7 0.0 3.7e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) Band_7 PF01145.25 KOS23205.1 - 2.4e-15 57.0 0.0 2.4e-15 57.0 0.0 3.5 2 2 0 3 3 3 1 SPFH domain / Band 7 family Carb_anhydrase PF00194.21 KOS23206.1 - 0.006 16.2 0.0 0.05 13.1 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic-type carbonic anhydrase adh_short PF00106.25 KOS23207.1 - 9.4e-08 31.7 0.8 1e-07 31.6 0.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase AdoHcyase_NAD PF00670.21 KOS23207.1 - 1.4e-05 25.3 0.4 1.4e-05 25.3 0.4 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.18 KOS23207.1 - 1.7e-05 24.8 0.6 1.7e-05 24.8 0.6 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain adh_short_C2 PF13561.6 KOS23207.1 - 2.7e-05 23.9 0.7 3.1e-05 23.6 0.7 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Shikimate_DH PF01488.20 KOS23207.1 - 0.00068 19.7 0.1 0.00081 19.5 0.1 1.0 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 KOS23207.1 - 0.0082 16.7 1.0 0.0095 16.5 1.0 1.1 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AAA_30 PF13604.6 KOS23207.1 - 0.12 12.1 2.1 0.14 11.9 2.1 1.1 1 0 0 1 1 1 0 AAA domain RicinB_lectin_2 PF14200.6 KOS23208.1 - 5.6e-17 62.3 5.3 7.2e-11 42.7 0.6 2.3 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 KOS23208.1 - 0.00023 21.4 0.0 0.0021 18.3 0.0 2.0 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Inhibitor_I66 PF16850.5 KOS23208.1 - 0.0072 16.2 0.1 0.014 15.3 0.1 1.7 1 1 0 1 1 1 1 Peptidase inhibitor I66 Hyr1 PF15789.5 KOS23208.1 - 0.14 11.7 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Hyphally regulated cell wall GPI-anchored protein 1 Glyco_hydro_125 PF06824.11 KOS23210.1 - 1e-151 505.6 0.0 1.2e-151 505.4 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) Phage_NinH PF06322.11 KOS23210.1 - 0.019 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Phage NinH protein Peptidase_A4 PF01828.17 KOS23211.1 - 9.1e-73 244.2 8.5 1.1e-72 243.9 8.5 1.1 1 0 0 1 1 1 1 Peptidase A4 family Fringe PF02434.16 KOS23212.1 - 1.6e-06 27.8 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Fringe-like DUF604 PF04646.12 KOS23212.1 - 3.1e-06 26.8 0.0 4.3e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function, DUF604 BRO1 PF03097.18 KOS23213.1 - 9.2e-114 380.2 0.0 1.8e-113 379.3 0.0 1.5 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 KOS23213.1 - 5.3e-80 268.9 2.8 5.3e-80 268.9 2.8 1.9 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Transp_cyt_pur PF02133.15 KOS23214.1 - 5.5e-153 509.9 37.7 6.4e-153 509.7 37.7 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin IBN_N PF03810.19 KOS23215.1 - 3.5e-10 39.7 0.7 2.7e-08 33.6 0.1 3.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain CAS_CSE1 PF03378.15 KOS23215.1 - 0.01 14.3 0.0 0.018 13.5 0.0 1.3 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus Xpo1 PF08389.12 KOS23215.1 - 0.026 14.6 0.0 0.25 11.4 0.0 2.7 2 0 0 2 2 2 0 Exportin 1-like protein Ribosomal_60s PF00428.19 KOS23215.1 - 0.11 13.0 2.4 0.44 11.2 2.4 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein PI31_Prot_N PF11566.8 KOS23216.1 - 6.2e-51 172.4 0.0 7.6e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 PI31 proteasome regulator N-terminal PI31_Prot_C PF08577.11 KOS23216.1 - 2.9e-18 66.8 15.6 2.9e-18 66.8 15.6 2.8 3 1 0 3 3 3 1 PI31 proteasome regulator Lant_dehydr_C PF14028.6 KOS23217.1 - 0.17 11.4 1.3 0.29 10.7 1.3 1.3 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term 2-Hacid_dh_C PF02826.19 KOS23218.1 - 7.4e-55 185.1 0.2 1.9e-54 183.7 0.1 1.7 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 KOS23218.1 - 2.7e-27 95.1 0.0 3.6e-27 94.7 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 KOS23218.1 - 9.6e-06 25.9 0.0 1.7e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 KOS23218.1 - 0.0023 18.0 0.0 0.0045 17.1 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AlaDh_PNT_C PF01262.21 KOS23218.1 - 0.0075 15.6 0.2 0.021 14.1 0.2 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain XdhC_C PF13478.6 KOS23218.1 - 0.016 15.8 0.1 0.16 12.5 0.0 2.4 2 0 0 2 2 2 0 XdhC Rossmann domain IlvN PF07991.12 KOS23218.1 - 0.037 13.6 0.0 0.06 12.9 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain K_oxygenase PF13434.6 KOS23220.1 - 3.7e-09 36.2 0.0 6.7e-07 28.8 0.0 2.3 1 1 1 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 KOS23220.1 - 1.7e-07 30.8 0.0 2.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS23220.1 - 4.5e-07 29.4 0.0 0.00019 20.8 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 KOS23220.1 - 5.7e-07 29.7 0.1 0.017 15.1 0.1 2.6 1 1 1 2 2 2 2 FAD-NAD(P)-binding FMO-like PF00743.19 KOS23220.1 - 0.0002 19.9 0.0 0.079 11.4 0.0 2.9 2 1 1 3 3 3 1 Flavin-binding monooxygenase-like Pyr_redox PF00070.27 KOS23220.1 - 0.016 15.8 1.0 1.8 9.1 0.2 3.0 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 KOS23220.1 - 0.02 14.1 0.0 0.034 13.4 0.0 1.4 1 0 0 1 1 1 0 Thi4 family FAD_binding_3 PF01494.19 KOS23220.1 - 0.051 12.8 0.1 0.085 12.1 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 KOS23220.1 - 0.11 12.7 1.5 0.23 11.7 0.2 2.2 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 KOS23220.1 - 0.14 10.9 0.1 2.2 6.9 0.1 2.1 2 0 0 2 2 2 0 HI0933-like protein Beta_helix PF13229.6 KOS23221.1 - 2.4e-09 37.2 18.2 9.7e-09 35.3 15.9 2.5 1 1 1 2 2 2 1 Right handed beta helix region FlaE PF07559.14 KOS23221.1 - 0.073 13.6 0.2 0.3 11.7 0.0 2.1 2 1 0 2 2 2 0 Flagellar basal body protein FlaE HORMA PF02301.18 KOS23222.1 - 5.9e-05 22.7 0.0 0.00019 21.1 0.0 1.8 1 1 0 1 1 1 1 HORMA domain Alpha_GJ PF03229.13 KOS23222.1 - 0.04 14.5 1.2 0.04 14.5 1.2 2.9 2 1 0 3 3 3 0 Alphavirus glycoprotein J RhoGEF PF00621.20 KOS23223.1 - 1.7e-24 87.1 0.5 3.4e-24 86.1 0.5 1.5 1 0 0 1 1 1 1 RhoGEF domain Zip PF02535.22 KOS23223.1 - 0.045 13.0 16.9 0.085 12.1 16.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Nod1 PF17114.5 KOS23223.1 - 0.17 12.0 0.0 0.57 10.3 0.0 1.9 2 0 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 DUF3507 PF12015.8 KOS23223.1 - 0.17 11.6 0.0 0.36 10.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) Lectin_N PF03954.14 KOS23223.1 - 1.1 9.0 3.0 9.8 5.9 0.6 2.8 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain CDC45 PF02724.14 KOS23223.1 - 2.1 6.6 9.5 3.5 5.8 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Cnn_1N PF07989.11 KOS23223.1 - 3.3 7.9 11.0 1 9.6 0.1 4.5 5 0 0 5 5 5 0 Centrosomin N-terminal motif 1 KH_1 PF00013.29 KOS23224.1 - 2.1e-09 37.0 0.0 1.4e-07 31.2 0.0 2.5 2 0 0 2 2 2 2 KH domain Harakiri PF15196.6 KOS23224.1 - 1.2 9.6 5.6 35 4.9 0.0 3.0 2 1 1 3 3 3 0 Activator of apoptosis harakiri DUF974 PF06159.13 KOS23225.1 - 2.3e-66 224.1 0.0 3.2e-66 223.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF974) RCDG1 PF15725.5 KOS23225.1 - 0.026 14.9 12.3 0.054 13.9 12.3 1.5 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein Sporozoite_P67 PF05642.11 KOS23225.1 - 0.093 10.8 2.2 0.2 9.7 2.1 1.5 1 1 0 1 1 1 0 Sporozoite P67 surface antigen OTCace_N PF02729.21 KOS23226.1 - 8.4e-43 145.9 0.0 1.1e-42 145.5 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 KOS23226.1 - 2.3e-40 138.3 0.0 3.1e-40 137.8 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ALS_ss_C PF10369.9 KOS23227.1 - 1.4e-14 54.0 0.0 1.2e-13 51.0 0.0 2.3 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 KOS23227.1 - 8.8e-14 51.0 0.1 1.6e-13 50.1 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 KOS23227.1 - 1.2e-07 31.4 0.0 2.5e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 ACT domain Spc7_N PF15402.6 KOS23227.1 - 0.57 8.4 2.7 0.79 7.9 2.7 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 SART-1 PF03343.13 KOS23228.1 - 9e-181 602.6 71.9 1e-180 602.4 71.9 1.0 1 0 0 1 1 1 1 SART-1 family DUF3712 PF12505.8 KOS23229.1 - 0.00017 21.8 0.0 0.001 19.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF3712) SNAP PF14938.6 KOS23230.1 - 2.1e-74 250.5 11.9 2.3e-74 250.3 11.9 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_12 PF13424.6 KOS23230.1 - 2.5e-06 27.7 14.9 0.0012 19.0 3.9 3.9 3 2 1 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 KOS23230.1 - 0.00051 20.0 12.6 0.72 10.1 0.4 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS23230.1 - 0.0011 18.8 13.4 2.5 8.3 0.3 5.1 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 KOS23230.1 - 0.0019 18.2 6.8 0.042 14.1 0.1 4.4 3 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 KOS23230.1 - 0.0041 17.7 9.8 0.32 11.7 0.2 5.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 KOS23230.1 - 0.0067 16.9 10.2 0.033 14.7 0.0 4.4 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 KOS23230.1 - 0.015 16.1 20.8 0.35 11.8 0.9 5.2 4 2 3 7 7 6 0 Tetratricopeptide repeat Orn_DAP_Arg_deC PF00278.22 KOS23230.1 - 0.16 12.3 0.1 0.39 11.0 0.0 1.6 2 0 0 2 2 2 0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain TPR_16 PF13432.6 KOS23230.1 - 0.24 12.1 19.2 0.57 10.9 4.3 4.8 2 2 3 5 5 5 0 Tetratricopeptide repeat Spore_II_R PF09551.10 KOS23230.1 - 0.52 10.8 7.2 0.44 11.0 0.4 2.6 2 1 1 3 3 3 0 Stage II sporulation protein R (spore_II_R) HHH_8 PF14716.6 KOS23230.1 - 0.66 10.4 7.7 1.3 9.4 1.6 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix domain Spatacsin_C PF14649.6 KOS23230.1 - 0.96 8.5 10.6 0.27 10.3 2.0 2.8 2 1 1 3 3 3 0 Spatacsin C-terminus DUF4375 PF14300.6 KOS23230.1 - 1.2 9.4 10.6 0.076 13.3 1.8 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) TarH PF02203.15 KOS23230.1 - 1.8 8.5 8.5 0.43 10.5 0.8 2.9 2 2 0 2 2 2 0 Tar ligand binding domain homologue DUF1771 PF08590.10 KOS23230.1 - 8.1 6.9 18.0 5 7.6 2.9 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF1771) Glyco_hydro_15 PF00723.21 KOS23231.1 - 3.2e-98 329.4 0.0 3.8e-98 329.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 CBM_20 PF00686.19 KOS23231.1 - 8.2e-29 99.4 0.1 1.9e-28 98.2 0.1 1.6 1 0 0 1 1 1 1 Starch binding domain Fascin PF06268.13 KOS23231.1 - 0.19 12.0 0.0 0.5 10.6 0.0 1.7 1 0 0 1 1 1 0 Fascin domain DENN PF02141.21 KOS23233.1 - 2.6e-58 197.0 0.0 4.3e-58 196.3 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 KOS23233.1 - 9.7e-15 54.3 1.1 1.9e-14 53.4 1.1 1.5 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 KOS23233.1 - 7.9e-14 52.2 0.0 1.7e-13 51.1 0.0 1.6 1 0 0 1 1 1 1 uDENN domain C1_2 PF03107.16 KOS23233.1 - 0.00093 19.5 4.7 0.0019 18.5 4.7 1.5 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 KOS23233.1 - 0.0037 17.1 4.8 0.0075 16.1 4.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 KOS23233.1 - 0.022 14.7 3.9 0.055 13.4 3.9 1.7 1 0 0 1 1 1 0 PHD-finger Zf_RING PF16744.5 KOS23233.1 - 0.036 14.2 1.6 0.08 13.1 1.6 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger SPA PF08616.10 KOS23233.1 - 0.043 13.8 0.1 0.084 12.8 0.1 1.4 1 0 0 1 1 1 0 Stabilization of polarity axis Zn_ribbon_17 PF17120.5 KOS23233.1 - 0.061 13.0 0.7 0.11 12.1 0.7 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Pneumo_phosprot PF02478.16 KOS23233.1 - 0.42 10.1 1.8 0.42 10.1 0.1 1.7 2 0 0 2 2 2 0 Pneumovirus phosphoprotein DUF726 PF05277.12 KOS23234.1 - 6e-92 308.2 0.0 6.7e-92 308.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) MRP-L20 PF12824.7 KOS23235.1 - 6.9e-48 162.9 2.7 8.3e-48 162.6 2.7 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Neugrin PF06413.11 KOS23235.1 - 0.023 14.7 0.5 0.046 13.7 0.2 1.7 2 0 0 2 2 2 0 Neugrin Not3 PF04065.15 KOS23236.1 - 1e-90 303.2 20.5 1.6e-90 302.6 20.5 1.3 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 KOS23236.1 - 4.2e-41 140.1 8.7 1e-40 138.8 8.7 1.7 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family DUF1192 PF06698.11 KOS23236.1 - 0.0061 16.6 1.4 0.034 14.2 0.3 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Syntaxin_2 PF14523.6 KOS23236.1 - 0.0099 16.2 2.1 0.0099 16.2 2.1 2.9 4 0 0 4 4 4 1 Syntaxin-like protein DUF2373 PF10180.9 KOS23236.1 - 0.027 14.3 3.3 0.06 13.2 3.3 1.6 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2373) HR1 PF02185.16 KOS23236.1 - 0.077 13.1 0.4 0.077 13.1 0.4 2.7 3 0 0 3 3 3 0 Hr1 repeat Ferritin-like PF12902.7 KOS23236.1 - 0.73 9.7 5.1 0.38 10.6 1.8 2.0 1 1 1 2 2 2 0 Ferritin-like Cep57_MT_bd PF06657.13 KOS23236.1 - 1.1 9.8 8.3 1.5 9.3 1.2 3.1 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 DUF4140 PF13600.6 KOS23236.1 - 2.5 8.6 4.8 16 6.0 0.4 3.0 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) 4HB_MCP_1 PF12729.7 KOS23236.1 - 5.5 6.5 13.4 2.4 7.7 7.3 2.3 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction Spc7 PF08317.11 KOS23237.1 - 0.1 11.4 0.2 0.15 11.0 0.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 KOS23237.1 - 4.2 5.8 10.8 5.9 5.3 10.8 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Tyr_Deacylase PF02580.16 KOS23238.1 - 1.1e-53 181.7 0.1 1.2e-53 181.5 0.1 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase HypA PF01155.19 KOS23239.1 - 0.31 11.1 1.9 0.58 10.2 1.9 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TFIIE-A_C PF11521.8 KOS23240.1 - 0.0062 16.8 1.0 0.008 16.4 1.0 1.3 1 0 0 1 1 1 1 C-terminal general transcription factor TFIIE alpha CENP-B_dimeris PF09026.10 KOS23240.1 - 0.087 13.2 11.2 0.11 13.0 11.2 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 KOS23240.1 - 0.5 8.4 4.6 0.52 8.3 4.6 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 KOS23240.1 - 0.74 10.2 8.4 0.84 10.0 8.4 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GCIP PF13324.6 KOS23240.1 - 1.6 8.3 3.9 1.4 8.4 3.9 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting TFIIF_alpha PF05793.12 KOS23240.1 - 2.7 6.5 6.9 2.5 6.6 6.9 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.9 KOS23240.1 - 3.4 6.7 10.0 3 6.9 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 KOS23240.1 - 8.2 4.4 6.2 7.1 4.6 6.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi Cg6151-P PF10233.9 KOS23241.1 - 2.1e-41 140.8 13.9 2.6e-41 140.5 13.9 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P DUF2518 PF10726.9 KOS23241.1 - 5.4 6.7 8.1 1.2 8.7 1.4 2.1 1 1 1 2 2 2 0 Protein of function (DUF2518) DUF202 PF02656.15 KOS23241.1 - 5.5 7.5 7.2 27 5.3 7.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) AAA_12 PF13087.6 KOS23242.1 - 1.3e-52 178.3 0.0 2.6e-52 177.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 KOS23242.1 - 1.1e-32 113.9 0.3 1.6e-16 60.9 0.0 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 KOS23242.1 - 4.7e-16 59.1 0.0 9.5e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 KOS23242.1 - 1e-12 48.6 0.1 2.5e-12 47.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain Dna2 PF08696.11 KOS23242.1 - 7e-11 42.3 0.0 2e-10 40.8 0.0 1.9 1 0 0 1 1 1 1 DNA replication factor Dna2 Cas_Cas4 PF01930.17 KOS23242.1 - 7.4e-09 35.9 0.1 1.6e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 KOS23242.1 - 9.8e-08 32.0 0.8 0.15 11.8 0.1 3.3 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase Helicase_RecD PF05127.14 KOS23242.1 - 5.7e-05 23.0 0.0 0.00016 21.6 0.0 1.7 1 1 0 1 1 1 1 Helicase PIF1 PF05970.14 KOS23242.1 - 0.00024 20.4 0.3 0.001 18.3 0.3 1.9 1 1 0 1 1 1 1 PIF1-like helicase AAA_16 PF13191.6 KOS23242.1 - 0.0011 19.3 0.0 0.0029 18.0 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 KOS23242.1 - 0.0018 18.0 0.4 0.0031 17.1 0.4 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain CbiA PF01656.23 KOS23242.1 - 0.0021 18.1 0.0 0.0061 16.6 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.14 KOS23242.1 - 0.0026 17.6 0.2 0.031 14.2 0.1 2.5 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B UvrD-helicase PF00580.21 KOS23242.1 - 0.0045 16.6 0.1 0.0089 15.6 0.1 1.5 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_25 PF13481.6 KOS23242.1 - 0.0077 15.8 0.2 0.23 11.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 KOS23242.1 - 0.0082 15.7 0.2 0.017 14.6 0.2 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF87 PF01935.17 KOS23242.1 - 0.015 15.4 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 Helicase HerA, central domain ResIII PF04851.15 KOS23242.1 - 0.019 15.0 0.0 0.042 13.8 0.0 1.6 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit FtsK_SpoIIIE PF01580.18 KOS23242.1 - 0.025 13.9 0.1 0.17 11.2 0.0 2.3 3 0 0 3 3 3 0 FtsK/SpoIIIE family DUF2075 PF09848.9 KOS23242.1 - 0.027 13.7 0.0 0.049 12.9 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_5 PF07728.14 KOS23242.1 - 0.047 13.7 0.3 0.13 12.2 0.1 1.8 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) NTPase_1 PF03266.15 KOS23242.1 - 0.056 13.4 0.2 0.14 12.1 0.2 1.6 1 0 0 1 1 1 0 NTPase AAA_33 PF13671.6 KOS23242.1 - 0.057 13.6 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 KOS23242.1 - 0.074 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 KOS23242.1 - 0.077 12.0 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RuvB_N PF05496.12 KOS23242.1 - 0.089 12.5 0.1 0.19 11.5 0.1 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TrwB_AAD_bind PF10412.9 KOS23242.1 - 0.12 11.3 0.2 0.21 10.5 0.2 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA PF00004.29 KOS23242.1 - 0.12 12.8 0.2 0.25 11.8 0.2 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IATP PF04568.12 KOS23243.1 - 3.3 8.2 10.5 0.11 12.9 0.7 2.7 3 0 0 3 3 3 0 Mitochondrial ATPase inhibitor, IATP SelR PF01641.18 KOS23244.1 - 7.6e-50 168.0 0.1 8.8e-50 167.8 0.1 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 KOS23244.1 - 0.023 14.9 0.3 0.05 13.8 0.3 1.5 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zinc_ribbon_10 PF10058.9 KOS23244.1 - 0.024 14.3 0.1 0.42 10.4 0.0 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 KOS23244.1 - 0.066 13.3 3.8 0.51 10.4 2.6 2.2 1 1 2 3 3 3 0 Double zinc ribbon zf-ribbon_3 PF13248.6 KOS23244.1 - 3.2 7.3 6.7 1.3 8.5 0.1 3.0 4 0 0 4 4 4 0 zinc-ribbon domain ArfGap PF01412.18 KOS23245.1 - 7.9e-40 135.6 0.7 7.9e-40 135.6 0.7 1.5 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf SUIM_assoc PF16619.5 KOS23245.1 - 0.0044 17.1 1.7 0.0044 17.1 1.7 2.3 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 KOS23245.1 - 0.018 14.7 2.3 0.032 13.8 2.3 1.3 1 0 0 1 1 1 0 Spt20 family OCD_Mu_crystall PF02423.15 KOS23246.1 - 5.9e-11 41.9 0.1 1e-05 24.7 0.0 2.8 3 0 0 3 3 3 2 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 KOS23246.1 - 0.028 14.5 0.1 13 5.8 0.0 3.2 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase Thiolase_N PF00108.23 KOS23247.1 - 3.3e-70 236.4 0.8 5.3e-70 235.8 0.8 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 KOS23247.1 - 8.2e-42 141.7 0.1 1.9e-41 140.6 0.1 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 KOS23247.1 - 0.00063 19.9 0.0 0.0019 18.3 0.0 1.9 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 KOS23247.1 - 0.016 14.8 0.6 0.34 10.5 0.3 2.4 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain Cadherin_tail PF15974.5 KOS23247.1 - 0.24 11.7 0.1 0.54 10.6 0.1 1.5 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Glyco_hydro_64 PF16483.5 KOS23248.1 - 1e-105 354.0 0.0 5.6e-105 351.6 0.0 1.8 1 1 0 1 1 1 1 Beta-1,3-glucanase DUF1977 PF09320.11 KOS23249.1 - 2.4e-30 104.9 0.0 6.4e-30 103.5 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1977) DnaJ PF00226.31 KOS23249.1 - 1.7e-18 66.5 0.1 2.7e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 DnaJ domain Ribosomal_S19 PF00203.21 KOS23250.1 - 1e-27 95.8 0.0 1.2e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 TFIID_30kDa PF03540.13 KOS23251.1 - 2e-24 85.3 0.2 3.3e-24 84.6 0.2 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID 23-30kDa subunit TAF4 PF05236.14 KOS23251.1 - 0.25 11.0 0.0 0.36 10.5 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family FoP_duplication PF13865.6 KOS23251.1 - 0.47 11.0 3.3 0.16 12.6 0.7 1.6 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 PriA_CRR PF18319.1 KOS23252.1 - 0.0085 16.1 0.7 0.0085 16.1 0.7 2.4 1 1 1 2 2 2 1 PriA DNA helicase Cys-rich region (CRR) domain CbiN PF02553.15 KOS23252.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Cobalt transport protein component CbiN Peptidase_S28 PF05577.12 KOS23253.1 - 4.2e-46 157.6 0.6 8.6e-46 156.6 0.6 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Steroid_dh PF02544.16 KOS23254.1 - 4.8e-15 55.8 0.0 6.2e-11 42.5 0.0 2.6 2 1 0 2 2 2 2 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 KOS23254.1 - 0.005 16.4 0.0 0.011 15.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) MINDY_DUB PF04424.13 KOS23255.1 - 5.7e-23 81.2 0.0 9e-23 80.5 0.0 1.3 1 0 0 1 1 1 1 MINDY deubiquitinase R3H PF01424.22 KOS23256.1 - 5e-12 45.6 0.2 9.7e-12 44.7 0.2 1.5 1 0 0 1 1 1 1 R3H domain RRM_1 PF00076.22 KOS23256.1 - 7.3e-05 22.5 0.0 0.00022 21.0 0.0 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Histone PF00125.24 KOS23257.1 - 2.8e-18 66.6 0.0 3.5e-18 66.2 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 KOS23257.1 - 8.8e-13 47.8 0.1 1.9e-12 46.7 0.1 1.6 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 KOS23257.1 - 2.1e-05 24.7 0.0 3.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Myb_DNA-binding PF00249.31 KOS23258.1 - 8.2e-05 22.7 0.0 0.00018 21.6 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 KOS23258.1 - 0.017 15.4 0.4 0.044 14.0 0.4 1.7 1 0 0 1 1 1 0 Myb-like DNA-binding domain DS PF01916.17 KOS23259.1 - 4.2e-131 436.5 0.0 4.7e-131 436.3 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Aldo_ket_red PF00248.21 KOS23260.1 - 1.4e-13 50.8 0.0 2.9e-13 49.7 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family CO_deh_flav_C PF03450.17 KOS23260.1 - 0.066 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase flavoprotein C-terminal domain GFO_IDH_MocA PF01408.22 KOS23261.1 - 1.2e-16 61.7 0.1 1.9e-16 60.9 0.1 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 KOS23261.1 - 0.0043 17.7 0.1 0.0071 17.0 0.1 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Skp1_POZ PF03931.15 KOS23262.1 - 2.1e-08 34.2 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain Ras PF00071.22 KOS23263.1 - 9.5e-48 161.8 0.0 1.2e-47 161.6 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 KOS23263.1 - 3.1e-20 72.6 0.0 5.3e-20 71.8 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 KOS23263.1 - 6.4e-06 25.7 0.0 1.8e-05 24.3 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family AAA_7 PF12775.7 KOS23263.1 - 0.075 12.5 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DASH_Dad1 PF08649.10 KOS23264.1 - 1.5e-26 92.3 1.3 1.8e-26 92.1 1.3 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 DASH_Dad4 PF08650.10 KOS23264.1 - 0.0079 16.1 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 DASH complex subunit Dad4 WVELL PF14043.6 KOS23264.1 - 0.07 13.0 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 WVELL protein SET PF00856.28 KOS23266.1 - 2.6e-11 44.2 0.0 3.3e-11 43.9 0.0 1.1 1 0 0 1 1 1 1 SET domain DBR1 PF05011.13 KOS23267.1 - 6.9e-46 156.1 0.0 4.3e-45 153.5 0.0 2.0 1 1 1 2 2 2 1 Lariat debranching enzyme, C-terminal domain Metallophos PF00149.28 KOS23267.1 - 6.9e-05 23.4 0.3 0.00015 22.3 0.2 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase GRP PF07172.11 KOS23267.1 - 0.81 10.4 13.4 0.37 11.5 10.0 2.0 2 0 0 2 2 2 0 Glycine rich protein family FA_desaturase PF00487.24 KOS23268.1 - 1.4e-25 90.6 20.0 1.4e-25 90.6 20.0 1.9 1 1 1 2 2 2 2 Fatty acid desaturase Lipid_DES PF08557.10 KOS23268.1 - 1.2e-16 59.8 0.1 2.1e-16 59.1 0.1 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Motile_Sperm PF00635.26 KOS23269.1 - 1e-23 83.3 0.2 2.7e-23 81.9 0.1 1.7 1 1 1 2 2 2 1 MSP (Major sperm protein) domain ASH PF15780.5 KOS23269.1 - 0.0046 17.1 0.0 0.025 14.8 0.0 2.1 2 0 0 2 2 2 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF4094 PF13334.6 KOS23269.1 - 0.0054 17.1 1.4 2.7 8.5 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4094) DUF2630 PF10944.8 KOS23269.1 - 0.095 13.2 0.1 0.22 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2630) Kelch_5 PF13854.6 KOS23271.1 - 7.5e-09 35.4 3.3 2.8e-08 33.6 0.5 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 KOS23271.1 - 9.2e-07 28.8 4.2 0.037 14.0 0.1 4.8 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 KOS23271.1 - 0.0047 16.5 3.9 0.12 12.0 0.1 4.1 4 1 0 4 4 4 1 Kelch motif GT87 PF09594.10 KOS23271.1 - 0.005 16.6 0.2 0.01 15.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 87 BIR PF00653.21 KOS23272.1 - 1e-43 147.9 4.6 1.9e-21 76.5 0.0 2.5 2 0 0 2 2 2 2 Inhibitor of Apoptosis domain AT_hook PF02178.19 KOS23272.1 - 0.00029 20.4 30.2 0.13 12.3 1.5 5.1 4 0 0 4 4 4 3 AT hook motif zf-BED PF02892.15 KOS23272.1 - 0.099 12.7 0.1 13 5.9 0.0 2.8 3 0 0 3 3 3 0 BED zinc finger MFS_1 PF07690.16 KOS23273.1 - 3.3e-30 105.2 29.7 3.3e-30 105.2 29.7 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2208 PF09973.9 KOS23273.1 - 0.11 12.1 0.3 2.2 7.8 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) DUF3671 PF12420.8 KOS23273.1 - 0.88 9.7 4.3 23 5.1 0.2 2.8 1 1 1 2 2 2 0 Protein of unknown function Acyl_transf_3 PF01757.22 KOS23273.1 - 1.1 8.3 34.2 0.2 10.7 14.3 2.7 2 1 0 2 2 2 0 Acyltransferase family GrpE PF01025.19 KOS23274.1 - 2.2e-46 157.5 3.3 3.3e-46 157.0 3.3 1.3 1 1 0 1 1 1 1 GrpE DUF334 PF03904.13 KOS23274.1 - 0.044 13.3 0.0 0.062 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF334) TraF PF13728.6 KOS23274.1 - 0.1 12.4 2.0 0.15 11.9 2.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein COG2 PF06148.11 KOS23275.1 - 0.18 11.9 2.2 0.17 11.9 0.3 1.9 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Cut12 PF11500.8 KOS23275.1 - 0.83 9.6 7.1 0.5 10.3 0.3 2.6 2 0 0 2 2 2 0 Spindle pole body formation-associated protein DUF3484 PF11983.8 KOS23275.1 - 0.97 10.6 0.0 0.97 10.6 0.0 3.5 4 0 0 4 4 4 0 Membrane-attachment and polymerisation-promoting switch DUF3275 PF11679.8 KOS23276.1 - 0.1 12.6 5.0 0.22 11.5 5.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) Cas3_C PF18395.1 KOS23276.1 - 0.15 12.5 1.0 0.35 11.4 1.0 1.6 1 0 0 1 1 1 0 Cas3 C-terminal domain RPN6_N PF18055.1 KOS23277.1 - 5.5e-39 133.1 1.2 5.5e-39 133.1 1.2 2.4 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 KOS23277.1 - 1.2e-21 77.2 0.8 4.7e-21 75.3 0.2 2.4 3 0 0 3 3 3 1 PCI domain RPN6_C_helix PF18503.1 KOS23277.1 - 7.9e-09 35.1 0.6 1.8e-08 33.9 0.6 1.7 1 0 0 1 1 1 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_MalT PF17874.1 KOS23277.1 - 5.2e-05 22.8 0.7 5.2e-05 22.8 0.7 2.2 3 1 0 3 3 3 1 MalT-like TPR region DDRGK PF09756.9 KOS23277.1 - 0.00012 21.8 0.2 0.00024 20.8 0.2 1.5 1 0 0 1 1 1 1 DDRGK domain TPR_12 PF13424.6 KOS23277.1 - 0.005 17.1 18.2 0.028 14.7 1.2 5.4 4 2 3 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 KOS23277.1 - 0.0061 16.5 1.1 4.2 7.6 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 KOS23277.1 - 0.02 15.0 1.0 30 5.0 0.0 4.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DprA_WH PF17782.1 KOS23277.1 - 0.022 14.9 0.1 0.32 11.1 0.0 2.8 3 0 0 3 3 3 0 DprA winged helix domain DUF1638 PF07796.11 KOS23277.1 - 0.025 14.7 0.1 0.071 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1638) HTH_Crp_2 PF13545.6 KOS23277.1 - 0.027 14.4 0.1 0.38 10.8 0.0 2.6 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain TPR_1 PF00515.28 KOS23277.1 - 0.09 12.6 0.1 16 5.5 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 KOS23277.1 - 1 10.2 4.3 42 5.1 0.1 4.5 5 1 0 5 5 4 0 Tetratricopeptide repeat TPR_4 PF07721.14 KOS23277.1 - 1.1 10.1 4.6 1.1 10.1 0.0 3.4 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_21 PF09976.9 KOS23277.1 - 8.1 6.1 12.1 4.1 7.1 0.4 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat-like domain TPR_14 PF13428.6 KOS23277.1 - 8.2 7.5 14.3 8.9 7.4 0.3 6.0 6 1 1 7 7 7 0 Tetratricopeptide repeat DNA_pol3_delta2 PF13177.6 KOS23278.1 - 1.1e-11 44.8 0.1 2.2e-11 43.8 0.1 1.5 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_22 PF13401.6 KOS23278.1 - 2e-06 28.1 0.1 1.4e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 KOS23278.1 - 2.5e-06 27.9 0.1 5.6e-06 26.8 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 KOS23278.1 - 0.00023 20.9 0.3 0.00061 19.6 0.3 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 KOS23278.1 - 0.00036 21.0 1.2 0.0026 18.1 0.4 2.5 2 1 0 2 2 2 1 AAA ATPase domain Rep_fac_C PF08542.11 KOS23278.1 - 0.0032 17.9 0.0 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 Replication factor C C-terminal domain Rad17 PF03215.15 KOS23278.1 - 0.0093 15.9 0.0 0.016 15.2 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain T4SS-DNA_transf PF02534.14 KOS23278.1 - 0.061 12.1 0.0 0.18 10.6 0.0 1.7 2 0 0 2 2 2 0 Type IV secretory system Conjugative DNA transfer ABC_tran PF00005.27 KOS23278.1 - 0.064 13.8 0.0 0.15 12.6 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 KOS23278.1 - 0.22 11.5 0.8 1 9.4 0.7 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AMP-binding PF00501.28 KOS23279.1 - 9.2e-88 294.6 0.1 1.2e-87 294.3 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 KOS23279.1 - 2.8e-25 89.1 0.9 8.2e-24 84.4 1.4 2.6 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 KOS23279.1 - 4.6e-19 68.1 0.3 1.2e-18 66.7 0.3 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus RFC1 PF08519.12 KOS23280.1 - 8.7e-57 191.7 0.0 2.1e-56 190.4 0.0 1.7 2 0 0 2 2 1 1 Replication factor RFC1 C terminal domain BRCT PF00533.26 KOS23280.1 - 4.8e-15 55.7 0.0 1.1e-14 54.6 0.0 1.6 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain AAA PF00004.29 KOS23280.1 - 4.6e-08 33.6 0.0 1.3e-07 32.1 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 KOS23280.1 - 3.1e-05 24.0 0.0 6.7e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 KOS23280.1 - 0.00042 20.2 0.0 0.0017 18.2 0.0 2.0 2 0 0 2 2 2 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 KOS23280.1 - 0.0033 17.8 0.1 0.023 15.1 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 KOS23280.1 - 0.0038 17.8 0.0 0.016 15.8 0.0 2.1 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 KOS23280.1 - 0.0048 17.2 0.0 0.056 13.7 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 KOS23280.1 - 0.011 15.5 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOS23280.1 - 0.026 14.7 0.0 0.089 12.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 KOS23280.1 - 0.026 14.6 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 KOS23280.1 - 0.027 14.7 0.6 0.17 12.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain NACHT PF05729.12 KOS23280.1 - 0.031 14.2 0.0 2.4 8.1 0.0 2.6 2 0 0 2 2 2 0 NACHT domain RuvB_N PF05496.12 KOS23280.1 - 0.094 12.5 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 KOS23280.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 NTPase Acyl-CoA_dh_1 PF00441.24 KOS23280.1 - 0.54 10.5 2.3 1.2 9.3 2.3 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Ribosomal_L16 PF00252.18 KOS23281.1 - 4.7e-30 104.3 1.1 6.7e-30 103.8 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e MMS1_N PF10433.9 KOS23285.1 - 4.4e-111 371.9 0.0 6.8e-111 371.3 0.0 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 KOS23285.1 - 3.6e-61 207.3 0.0 8.9e-61 206.0 0.0 1.7 1 0 0 1 1 1 1 CPSF A subunit region Ion_trans PF00520.31 KOS23286.1 - 2.7e-10 39.9 18.8 6.2e-10 38.7 18.8 1.6 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 KOS23286.1 - 1.2e-05 24.2 9.6 0.011 14.4 0.1 2.2 1 1 1 2 2 2 2 Polycystin cation channel Adeno_E3_CR2 PF02439.15 KOS23287.1 - 0.02 14.7 0.6 0.041 13.6 0.6 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Ribosomal_60s PF00428.19 KOS23288.1 - 8.2 7.1 18.5 1.1 9.9 0.5 3.7 3 0 0 3 3 3 0 60s Acidic ribosomal protein Peptidase_S9 PF00326.21 KOS23289.1 - 3.2e-43 147.7 0.0 5.2e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 KOS23289.1 - 0.00018 20.3 0.0 0.016 13.9 0.0 2.2 1 1 0 1 1 1 1 Acetyl xylan esterase (AXE1) Abhydrolase_1 PF00561.20 KOS23289.1 - 0.00039 20.1 0.1 0.088 12.4 0.4 2.4 1 1 0 2 2 2 2 alpha/beta hydrolase fold DUF2457 PF10446.9 KOS23289.1 - 0.068 12.3 7.4 0.1 11.7 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 KOS23289.1 - 0.13 11.5 6.4 0.2 10.9 6.4 1.2 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 KOS23289.1 - 0.24 11.4 3.4 0.44 10.6 3.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 KOS23289.1 - 0.49 10.1 2.5 0.96 9.1 2.5 1.4 1 0 0 1 1 1 0 FAM176 family TAP42 PF04177.12 KOS23289.1 - 1.6 7.8 4.9 2.3 7.3 4.9 1.1 1 0 0 1 1 1 0 TAP42-like family PBP1_TM PF14812.6 KOS23289.1 - 5.2 7.5 9.8 11 6.5 9.8 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Peptidase_M28 PF04389.17 KOS23290.1 - 7.7e-30 104.1 0.2 1e-29 103.7 0.2 1.2 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 KOS23290.1 - 5.4e-06 26.2 0.7 1e-05 25.3 0.7 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 R3H-assoc PF13902.6 KOS23291.1 - 0.0021 18.4 4.1 0.0045 17.4 2.5 2.3 2 1 0 2 2 2 1 R3H-associated N-terminal domain R3H PF01424.22 KOS23291.1 - 0.0061 16.5 0.1 0.03 14.3 0.0 2.1 2 0 0 2 2 2 1 R3H domain PQ-loop PF04193.14 KOS23293.1 - 1e-24 86.1 7.2 3.5e-13 49.1 0.9 3.1 2 1 1 3 3 3 2 PQ loop repeat MASE5 PF17178.4 KOS23293.1 - 0.18 11.6 7.5 0.24 11.2 4.4 2.1 2 0 0 2 2 2 0 Membrane-associated sensor PsbH PF00737.20 KOS23293.1 - 0.47 10.2 0.1 0.47 10.2 0.1 2.6 3 0 0 3 3 3 0 Photosystem II 10 kDa phosphoprotein G_glu_transpept PF01019.21 KOS23294.1 - 6.2e-140 467.4 0.0 7.1e-140 467.2 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Amidohydro_3 PF07969.11 KOS23295.1 - 5.2e-68 230.6 2.1 6.5e-68 230.3 2.1 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_1 PF01979.20 KOS23295.1 - 4.2e-09 36.2 0.1 0.049 12.9 0.0 3.8 3 1 0 3 3 3 3 Amidohydrolase family DUF2871 PF11070.8 KOS23296.1 - 4.5 7.5 7.5 4.7 7.5 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2871) BPL_LplA_LipB PF03099.19 KOS23297.1 - 3.8e-05 23.6 0.0 7.9e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family Chorismate_synt PF01264.21 KOS23298.1 - 5.2e-139 462.5 0.0 5.9e-139 462.3 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase SurA_N_3 PF13624.6 KOS23299.1 - 2.2 8.1 7.0 0.47 10.2 0.2 2.4 2 0 0 2 2 2 0 SurA N-terminal domain BC10 PF06726.12 KOS23300.1 - 9.8e-18 64.2 10.9 2.2e-17 63.0 10.9 1.6 1 0 0 1 1 1 1 Bladder cancer-related protein BC10 Sec5 PF15469.6 KOS23301.1 - 0.35 10.7 5.0 1.3 8.7 5.0 2.1 1 1 0 1 1 1 0 Exocyst complex component Sec5 Spt5_N PF11942.8 KOS23301.1 - 8 7.5 14.9 3 8.9 2.6 4.1 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal Pro_isomerase PF00160.21 KOS23302.1 - 2.1e-47 161.3 0.1 3.7e-47 160.5 0.1 1.4 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_2 PF07719.17 KOS23302.1 - 1.9e-06 27.5 2.1 0.0006 19.7 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 KOS23302.1 - 1.6e-05 24.5 1.3 0.00064 19.4 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 KOS23302.1 - 0.027 14.7 1.0 0.28 11.5 0.6 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 KOS23302.1 - 0.058 13.6 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat Thioredoxin_3 PF13192.6 KOS23302.1 - 0.18 11.9 0.1 0.96 9.5 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain TPR_9 PF13371.6 KOS23302.1 - 0.3 11.2 4.5 0.36 11.0 3.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF87 PF01935.17 KOS23303.1 - 0.0015 18.7 0.0 0.5 10.4 0.0 2.3 2 0 0 2 2 2 1 Helicase HerA, central domain FtsK_SpoIIIE PF01580.18 KOS23303.1 - 0.0021 17.5 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_16 PF13191.6 KOS23303.1 - 0.0068 16.8 0.0 0.11 12.9 0.0 2.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 KOS23303.1 - 0.0076 16.5 0.0 0.8 10.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 KOS23303.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin PBP1_TM PF14812.6 KOS23303.1 - 0.14 12.6 10.9 0.35 11.3 10.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 KOS23303.1 - 0.38 10.5 10.8 0.75 9.5 10.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 KOS23303.1 - 0.94 8.7 14.1 1.9 7.7 14.1 1.4 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 KOS23303.1 - 1.1 9.6 6.4 0.22 11.7 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) YL1 PF05764.13 KOS23303.1 - 1.2 9.2 7.6 0.067 13.3 2.1 1.7 2 0 0 2 2 2 0 YL1 nuclear protein DNA_pol_phi PF04931.13 KOS23303.1 - 3.1 5.8 10.4 4.5 5.2 10.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 KOS23303.1 - 4.1 5.6 5.9 6.2 5.0 5.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.13 KOS23303.1 - 6 5.3 6.2 11 4.4 6.2 1.4 1 0 0 1 1 1 0 Utp14 protein CENP-B_dimeris PF09026.10 KOS23303.1 - 9.6 6.7 18.3 27 5.2 18.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GST_N_3 PF13417.6 KOS23304.1 - 2.7e-18 66.1 0.0 7.3e-18 64.8 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 KOS23304.1 - 5e-17 62.0 0.0 1.1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 KOS23304.1 - 1.6e-09 37.9 0.0 2.1e-06 28.0 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 KOS23304.1 - 7.3e-06 25.9 0.4 1.7e-05 24.7 0.4 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 KOS23304.1 - 0.079 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 KOS23304.1 - 0.19 12.0 0.0 0.68 10.2 0.0 1.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain XAP5 PF04921.14 KOS23305.1 - 2.8e-92 309.1 0.1 2.8e-92 309.1 0.1 2.4 1 1 1 2 2 2 1 XAP5, circadian clock regulator DUF4604 PF15377.6 KOS23305.1 - 0.00042 20.8 12.4 0.00042 20.8 12.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4604) Pox_Ag35 PF03286.14 KOS23305.1 - 0.53 10.0 15.7 0.32 10.7 4.3 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Nop14 PF04147.12 KOS23305.1 - 0.94 7.6 15.7 1.2 7.2 15.7 1.2 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 KOS23305.1 - 7.8 6.1 22.2 0.073 12.8 11.9 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein adh_short_C2 PF13561.6 KOS23307.1 - 9.7e-52 175.8 0.7 1.2e-51 175.5 0.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS23307.1 - 5.6e-38 130.4 1.1 1e-37 129.5 1.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS23307.1 - 7.6e-11 42.3 1.2 1e-10 41.8 1.2 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS23307.1 - 0.00078 19.0 0.2 0.0035 16.8 0.3 2.1 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 KOS23307.1 - 0.01 15.0 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 KOS23307.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 KOS23307.1 - 0.018 14.1 0.0 0.024 13.6 0.0 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family DUF218 PF02698.17 KOS23308.1 - 2.5e-23 82.5 0.0 3.2e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain Methyltransf_10 PF05971.12 KOS23309.1 - 9.1e-66 222.2 0.0 1.4e-65 221.6 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 KOS23309.1 - 4.2e-05 23.1 0.0 7.2e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 KOS23309.1 - 0.00072 19.0 0.0 0.0013 18.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 KOS23309.1 - 0.025 14.5 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MmcB-like PF06319.12 KOS23311.1 - 0.23 11.1 0.9 11 5.7 0.0 2.3 2 0 0 2 2 2 0 DNA repair protein MmcB-like Fungal_trans PF04082.18 KOS23312.1 - 5.6e-11 42.0 0.1 8.2e-11 41.4 0.1 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 KOS23312.1 - 8e-06 25.9 7.2 1.6e-05 24.9 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain But2 PF09792.9 KOS23313.1 - 3e-44 150.9 0.0 5.6e-44 150.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin 3 binding protein But2 C-terminal domain CAP_assoc_N PF14504.6 KOS23314.1 - 0.017 14.9 0.6 0.018 14.8 0.6 1.0 1 0 0 1 1 1 0 CAP-associated N-terminal adh_short_C2 PF13561.6 KOS23316.1 - 3.8e-57 193.5 0.0 4.4e-57 193.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS23316.1 - 1.8e-46 158.1 0.0 2.6e-46 157.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS23316.1 - 3.6e-12 46.6 0.0 5.3e-12 46.0 0.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 KOS23316.1 - 0.00053 19.5 0.2 0.0012 18.3 0.2 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Sacchrp_dh_NADP PF03435.18 KOS23316.1 - 0.0033 17.7 0.1 0.006 16.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain ThiF PF00899.21 KOS23316.1 - 0.02 14.3 0.4 0.34 10.2 0.1 2.1 1 1 1 2 2 2 0 ThiF family Ldh_1_N PF00056.23 KOS23316.1 - 0.022 14.9 0.0 0.038 14.1 0.0 1.4 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain HHH_5 PF14520.6 KOS23316.1 - 0.026 15.1 0.0 0.053 14.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain Polysacc_synt_2 PF02719.15 KOS23316.1 - 0.076 12.1 0.0 0.095 11.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Radial_spoke_3 PF06098.11 KOS23317.1 - 4.4 6.5 8.8 5.9 6.1 8.8 1.1 1 0 0 1 1 1 0 Radial spoke protein 3 Spc7_N PF15402.6 KOS23317.1 - 4.6 5.4 8.9 5.6 5.1 8.9 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Spt5-NGN PF03439.13 KOS23318.1 - 3.4e-22 78.1 0.0 5.8e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 KOS23318.1 - 9.9e-22 77.8 11.6 9.9e-22 77.8 11.6 4.3 2 1 1 3 3 3 1 Spt5 transcription elongation factor, acidic N-terminal CTD PF12815.7 KOS23318.1 - 1.9e-12 47.6 16.0 1.9e-12 47.6 16.0 4.1 1 1 1 2 2 2 1 Spt5 C-terminal nonapeptide repeat binding Spt4 KOW PF00467.29 KOS23318.1 - 0.00035 20.4 18.2 0.0063 16.4 1.1 5.1 6 1 1 7 7 7 2 KOW motif DUF3912 PF13051.6 KOS23318.1 - 0.049 13.9 0.0 0.16 12.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3912) YajC PF02699.15 KOS23318.1 - 0.16 11.8 3.1 3.4 7.6 0.5 3.4 3 0 0 3 3 3 0 Preprotein translocase subunit adh_short_C2 PF13561.6 KOS23321.1 - 4.3e-52 177.0 0.0 5.9e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 KOS23321.1 - 1.2e-42 145.6 0.0 1.6e-42 145.2 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 KOS23321.1 - 2.8e-12 46.9 0.0 4.8e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 KR domain Pyr_redox_2 PF07992.14 KOS23321.1 - 0.0014 17.9 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GDP_Man_Dehyd PF16363.5 KOS23321.1 - 0.011 15.2 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Methyltransf_11 PF08241.12 KOS23321.1 - 0.021 15.4 0.0 3 8.6 0.0 2.4 1 1 0 1 1 1 0 Methyltransferase domain NAD_binding_7 PF13241.6 KOS23321.1 - 0.098 13.1 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding 3Beta_HSD PF01073.19 KOS23321.1 - 0.11 11.5 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Methyltransf_25 PF13649.6 KOS23321.1 - 0.12 13.0 0.1 7.5 7.3 0.1 2.6 1 1 1 2 2 2 0 Methyltransferase domain SAGA-Tad1 PF12767.7 KOS23321.1 - 0.2 11.4 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit Aa_trans PF01490.18 KOS23322.1 - 1.7e-72 244.4 23.3 2.1e-72 244.1 23.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Polysacc_synt_4 PF04669.13 KOS23323.1 - 2.2e-23 82.8 1.0 9.2e-22 77.5 1.0 2.1 1 1 0 1 1 1 1 Polysaccharide biosynthesis Abhydrolase_1 PF00561.20 KOS23325.1 - 3.2e-05 23.7 0.0 5.6e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 KOS23325.1 - 0.019 14.8 0.0 0.031 14.1 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Cupin_2 PF07883.11 KOS23326.1 - 1e-13 50.8 0.1 1.7e-13 50.1 0.1 1.3 1 0 0 1 1 1 1 Cupin domain Cupin_3 PF05899.12 KOS23326.1 - 0.00011 21.8 0.0 0.00017 21.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF861) Cupin_1 PF00190.22 KOS23326.1 - 0.00057 19.5 0.0 0.00072 19.2 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_6 PF12852.7 KOS23326.1 - 0.0012 18.6 0.3 0.0034 17.1 0.0 1.7 1 1 1 2 2 2 1 Cupin AraC_binding PF02311.19 KOS23326.1 - 0.0069 16.3 0.1 0.011 15.6 0.1 1.4 1 1 0 1 1 1 1 AraC-like ligand binding domain MFS_1 PF07690.16 KOS23327.1 - 4.5e-29 101.5 21.1 4.5e-29 101.5 21.1 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 KOS23327.1 - 2.3e-08 33.3 7.4 2.3e-08 33.3 7.4 2.1 2 0 0 2 2 2 1 Sugar (and other) transporter DUF1769 PF08588.10 KOS23328.1 - 1.6e-28 98.7 0.3 3.7e-28 97.5 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1769) DUF3446 PF11928.8 KOS23328.1 - 0.018 15.3 7.5 0.034 14.4 7.5 1.4 1 0 0 1 1 1 0 Early growth response N-terminal domain mRNA_triPase PF02940.15 KOS23329.1 - 5.4e-51 173.4 0.1 7.9e-51 172.9 0.1 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Xan_ur_permease PF00860.20 KOS23330.1 - 9.4e-64 215.5 23.7 7.1e-62 209.3 23.7 2.1 1 1 0 1 1 1 1 Permease family Oxidored_molyb PF00174.19 KOS23331.1 - 5e-57 192.3 0.0 7.4e-57 191.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 KOS23331.1 - 3.5e-23 82.1 0.0 3.2e-12 46.7 0.0 3.0 3 0 0 3 3 3 2 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 KOS23331.1 - 1.5e-12 47.4 0.1 3.1e-12 46.5 0.1 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain BNR PF02012.20 KOS23331.1 - 0.35 11.0 1.2 0.95 9.7 0.2 2.4 2 0 0 2 2 2 0 BNR/Asp-box repeat RPN2_C PF18004.1 KOS23332.1 - 5.7e-56 188.9 5.5 5.7e-56 188.9 5.5 2.3 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 KOS23332.1 - 6.3e-38 127.3 22.8 1.2e-08 35.0 0.0 8.9 9 0 0 9 9 9 6 Proteasome/cyclosome repeat HEAT_2 PF13646.6 KOS23332.1 - 2.6e-22 79.0 0.1 8.8e-15 54.9 0.0 5.2 3 1 0 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 KOS23332.1 - 2.6e-06 27.8 0.8 0.0023 18.4 0.0 5.1 4 1 1 5 5 5 2 HEAT-like repeat HEAT PF02985.22 KOS23332.1 - 1.8e-05 24.6 2.1 1.2 9.6 0.0 6.0 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 KOS23332.1 - 0.012 15.6 0.1 2.1 8.4 0.0 3.2 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 GHMP_kinases_N PF00288.26 KOS23332.1 - 7 7.0 6.5 1.2 9.5 0.1 2.9 3 0 0 3 3 3 0 GHMP kinases N terminal domain Abhydrolase_6 PF12697.7 KOS23333.1 - 9.5e-05 23.1 0.8 0.00016 22.4 0.8 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 KOS23333.1 - 0.0055 16.6 0.0 0.011 15.6 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF3446 PF11928.8 KOS23333.1 - 0.0057 16.9 10.0 0.011 16.0 10.0 1.5 1 0 0 1 1 1 1 Early growth response N-terminal domain DUF4667 PF15700.5 KOS23333.1 - 0.014 15.5 3.9 0.02 15.0 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Abhydrolase_1 PF00561.20 KOS23333.1 - 0.035 13.8 0.4 0.24 11.0 0.0 2.4 2 1 1 3 3 3 0 alpha/beta hydrolase fold Chorion_2 PF03964.15 KOS23333.1 - 0.2 12.5 8.0 0.073 13.9 5.0 1.8 2 0 0 2 2 2 0 Chorion family 2 BTB PF00651.31 KOS23334.1 - 1.6e-07 31.5 0.1 7.8e-07 29.3 0.0 2.1 3 0 0 3 3 3 1 BTB/POZ domain Skp1_POZ PF03931.15 KOS23334.1 - 0.006 16.7 0.0 0.019 15.1 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain PCI PF01399.27 KOS23335.1 - 1e-08 35.6 0.0 7.1e-08 32.9 0.0 2.4 2 1 0 2 2 2 1 PCI domain Ribosomal_L18A PF01775.17 KOS23336.1 - 7.9e-54 180.9 0.2 9.9e-54 180.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Acetyltransf_3 PF13302.7 KOS23337.1 - 3e-29 102.5 0.0 4.8e-29 101.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 KOS23337.1 - 6.5e-05 23.1 0.0 0.00012 22.2 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Ric8 PF10165.9 KOS23338.1 - 2.7e-111 372.9 0.0 3.3e-111 372.6 0.0 1.0 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn Rif1_N PF12231.8 KOS23339.1 - 5.9e-123 410.6 0.1 8e-123 410.1 0.1 1.2 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Sugar_tr PF00083.24 KOS23340.1 - 2.1e-106 356.5 21.2 2.5e-106 356.2 21.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS23340.1 - 7.3e-23 81.0 33.4 1.9e-14 53.3 8.2 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily OATP PF03137.20 KOS23340.1 - 3.6e-05 22.3 1.8 3.6e-05 22.3 1.8 2.0 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF697 PF05128.12 KOS23340.1 - 0.12 12.1 1.1 3.2 7.4 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF697) Aldo_ket_red PF00248.21 KOS23341.1 - 1.6e-43 149.0 0.0 2.1e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family LRR_4 PF12799.7 KOS23342.1 - 2.5e-48 161.2 44.6 2.4e-08 34.1 0.9 7.0 1 1 11 12 12 12 10 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 KOS23342.1 - 5.3e-23 80.6 18.3 1e-07 31.6 2.3 5.6 2 2 3 6 6 6 5 Leucine rich repeat LRR_9 PF14580.6 KOS23342.1 - 4.4e-16 58.9 10.8 1.9e-07 30.7 0.6 4.0 1 1 3 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 KOS23342.1 - 8.2e-05 22.6 18.1 2.9 8.8 0.1 7.8 8 0 0 8 8 8 1 Leucine Rich Repeat LRR_6 PF13516.6 KOS23342.1 - 0.00016 21.5 19.8 0.76 10.0 0.8 7.8 8 0 0 8 8 8 2 Leucine Rich repeat DKNYY PF13644.6 KOS23342.1 - 0.076 13.8 0.0 0.33 11.7 0.0 1.9 1 1 0 1 1 1 0 DKNYY family DUF2322 PF10084.9 KOS23342.1 - 0.23 11.5 1.2 28 4.8 0.0 3.4 2 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2322) Arm_3 PF16186.5 KOS23342.1 - 3.1 7.4 5.7 20 4.8 0.1 3.6 2 1 1 3 3 3 0 Atypical Arm repeat IMS PF00817.20 KOS23343.1 - 1.6e-44 151.5 0.3 4e-44 150.2 0.3 1.7 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 KOS23343.1 - 6.6e-14 52.6 1.0 1.4e-13 51.5 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 KOS23343.1 - 0.00033 20.8 0.0 0.00084 19.5 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif BAF PF02961.14 KOS23343.1 - 0.097 13.1 0.0 0.28 11.7 0.0 1.7 1 0 0 1 1 1 0 Barrier to autointegration factor Cornichon PF03311.14 KOS23345.1 - 9e-50 168.1 13.0 1e-49 167.9 13.0 1.0 1 0 0 1 1 1 1 Cornichon protein CTP_transf_like PF01467.26 KOS23346.1 - 0.0016 18.6 0.0 0.0085 16.3 0.0 2.0 2 0 0 2 2 2 1 Cytidylyltransferase-like SET PF00856.28 KOS23347.1 - 3e-07 31.0 0.0 4.2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 SET domain WD40 PF00400.32 KOS23348.1 - 8.9e-30 102.3 3.7 1.8e-06 28.5 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS23348.1 - 4.5e-15 55.7 0.0 5e-06 26.7 0.1 4.0 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 KOS23348.1 - 0.0043 16.9 1.1 0.48 10.3 0.3 2.8 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 KOS23348.1 - 0.29 10.0 2.0 27 3.6 0.0 3.2 2 2 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Methyltransf_24 PF13578.6 KOS23349.1 - 4.6e-09 37.2 0.0 9.1e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 KOS23349.1 - 0.054 14.2 0.0 0.11 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 KOS23349.1 - 0.1 12.4 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain TrkA_N PF02254.18 KOS23349.1 - 0.22 11.8 0.0 0.71 10.2 0.0 1.8 2 0 0 2 2 2 0 TrkA-N domain Raf1_N PF18578.1 KOS23350.1 - 0.0064 17.0 0.0 0.0091 16.5 0.0 1.2 1 0 0 1 1 1 1 Rubisco accumulation factor 1 alpha helical domain LapA_dom PF06305.11 KOS23351.1 - 0.018 14.8 0.2 0.065 13.0 0.2 1.9 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Miga PF10265.9 KOS23351.1 - 0.066 12.2 8.8 0.033 13.2 6.2 1.4 1 1 1 2 2 2 0 Mitoguardin EphA2_TM PF14575.6 KOS23351.1 - 0.066 14.1 0.2 0.19 12.6 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.6 KOS23351.1 - 0.076 13.5 0.0 0.26 11.8 0.0 1.9 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT TMEM171 PF15471.6 KOS23351.1 - 0.21 10.5 0.7 4.5 6.2 0.2 2.4 2 0 0 2 2 2 0 Transmembrane protein family 171 TMEM154 PF15102.6 KOS23351.1 - 0.28 11.1 2.8 0.52 10.2 0.0 2.4 2 0 0 2 2 2 0 TMEM154 protein family Flavodoxin_2 PF02525.17 KOS23352.1 - 5e-07 29.6 0.0 6.2e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold FMN_red PF03358.15 KOS23352.1 - 1.9e-06 27.7 0.0 2.5e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_1 PF00258.25 KOS23352.1 - 0.00018 21.7 0.1 0.0036 17.5 0.1 2.2 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 KOS23352.1 - 0.16 12.2 0.0 0.76 10.0 0.0 1.9 1 1 1 2 2 2 0 Flavodoxin domain TPT PF03151.16 KOS23353.1 - 3.7e-33 115.1 16.5 4.5e-33 114.8 16.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 KOS23353.1 - 2.7e-05 23.5 19.5 4.5e-05 22.8 19.5 1.3 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 KOS23353.1 - 0.00068 19.8 32.2 0.032 14.4 13.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF2929 PF11151.8 KOS23353.1 - 6.1 7.2 9.2 0.44 10.9 1.9 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2929) RasGAP PF00616.19 KOS23354.1 - 4.3e-51 173.6 0.0 1e-50 172.4 0.0 1.7 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 KOS23354.1 - 3.5e-50 169.7 6.1 2.1e-49 167.2 6.1 2.5 1 0 0 1 1 1 1 RasGAP C-terminus IQ PF00612.27 KOS23354.1 - 3.8e-18 63.5 43.5 0.015 15.1 0.1 14.9 15 0 0 15 15 15 7 IQ calmodulin-binding motif CH PF00307.31 KOS23354.1 - 3.3e-11 43.3 0.0 1.1e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain Trypan_PARP PF05887.11 KOS23354.1 - 0.06 13.3 3.0 0.15 12.1 3.0 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AAA_assoc_C PF09821.9 KOS23354.1 - 1.7 9.2 7.1 1.2 9.6 1.0 3.5 3 0 0 3 3 3 0 C-terminal AAA-associated domain DUF155 PF02582.14 KOS23356.1 - 7.7e-56 189.0 0.1 3.6e-55 186.8 0.0 2.0 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 Collectrin PF16959.5 KOS23356.1 - 0.077 12.8 0.1 9.9 5.9 0.1 2.4 2 0 0 2 2 2 0 Renal amino acid transporter SGL PF08450.12 KOS23358.1 - 1.3e-23 83.9 0.1 1.8e-23 83.4 0.1 1.3 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 KOS23358.1 - 2.2e-05 24.5 0.0 0.00012 22.2 0.0 2.0 1 1 0 1 1 1 1 Strictosidine synthase Arylesterase PF01731.20 KOS23358.1 - 0.0044 17.2 0.0 0.016 15.4 0.0 2.0 1 1 0 1 1 1 1 Arylesterase RabGAP-TBC PF00566.18 KOS23359.1 - 1.5e-35 122.8 0.0 2.1e-35 122.3 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain S36_mt PF10937.8 KOS23359.1 - 0.15 13.7 0.4 1.5 10.4 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S36, mitochondrial EI24 PF07264.11 KOS23360.1 - 3.4e-07 30.7 22.0 6.4e-07 29.8 22.0 1.4 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) COG5 PF10392.9 KOS23361.1 - 2.4e-40 137.8 1.8 4.3e-39 133.7 0.2 2.7 3 0 0 3 3 3 1 Golgi transport complex subunit 5 SRX PF09201.10 KOS23361.1 - 0.042 13.7 0.1 0.074 12.9 0.1 1.3 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit V-ATPase_G_2 PF16999.5 KOS23361.1 - 0.13 12.7 2.6 0.63 10.5 1.4 2.4 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit DUF4407 PF14362.6 KOS23361.1 - 0.2 11.0 1.7 0.98 8.7 1.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Actino_peptide PF14408.6 KOS23361.1 - 0.63 10.2 8.8 1.4 9.1 8.8 1.5 1 0 0 1 1 1 0 Ribosomally synthesised peptide in actinomycetes DUF2434 PF10361.9 KOS23362.1 - 1.2e-129 431.5 7.8 1.6e-129 431.1 7.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2434) Zn_clus PF00172.18 KOS23364.1 - 2.2e-08 34.1 9.9 3.3e-08 33.5 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2722 PF10846.8 KOS23364.1 - 0.0005 19.1 9.4 0.0007 18.7 9.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 KOS23364.1 - 0.0016 18.6 18.0 0.0025 17.9 18.0 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Fungal_trans PF04082.18 KOS23364.1 - 0.013 14.6 0.2 0.013 14.6 0.2 1.8 2 1 0 2 2 1 0 Fungal specific transcription factor domain EIF4E-T PF10477.9 KOS23364.1 - 0.031 13.1 14.8 0.046 12.6 14.8 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Eapp_C PF10238.9 KOS23364.1 - 0.042 13.9 5.0 0.084 12.9 5.0 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein SpoIIP PF07454.11 KOS23364.1 - 0.045 13.2 4.6 0.073 12.5 4.6 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 KOS23364.1 - 0.065 13.4 1.8 0.11 12.7 1.8 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 KOS23364.1 - 0.069 11.9 4.8 0.1 11.3 4.8 1.2 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 KOS23364.1 - 0.16 12.1 4.5 0.39 10.9 4.5 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SLC12 PF03522.15 KOS23364.1 - 0.17 10.9 2.4 0.23 10.4 2.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4770 PF15994.5 KOS23364.1 - 0.18 12.0 6.1 0.35 11.1 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CDC45 PF02724.14 KOS23364.1 - 0.19 10.0 1.8 0.26 9.6 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3801 PF12687.7 KOS23364.1 - 0.29 11.2 9.2 0.42 10.6 9.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Lin-8 PF03353.15 KOS23364.1 - 0.36 10.4 8.5 0.56 9.7 8.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PAT1 PF09770.9 KOS23364.1 - 0.49 8.6 14.6 0.59 8.3 14.6 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 KOS23364.1 - 0.89 8.2 3.9 1.3 7.7 3.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup FAM176 PF14851.6 KOS23364.1 - 1.6 8.4 6.9 4 7.1 6.9 1.6 1 0 0 1 1 1 0 FAM176 family DUF3824 PF12868.7 KOS23364.1 - 2.4 8.8 17.2 0.13 12.9 11.2 2.0 2 0 0 2 2 1 0 Domain of unknwon function (DUF3824) Tim54 PF11711.8 KOS23364.1 - 3.3 6.4 9.1 5.5 5.7 9.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Pex14_N PF04695.13 KOS23364.1 - 4.7 7.9 21.5 13 6.5 21.5 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NARP1 PF12569.8 KOS23364.1 - 5.1 5.9 9.3 7.9 5.3 9.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Glyco_transf_20 PF00982.21 KOS23365.1 - 4.1e-150 500.6 0.0 5.6e-150 500.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 KOS23365.1 - 1.7e-69 233.6 0.0 3.2e-69 232.6 0.0 1.5 1 0 0 1 1 1 1 Trehalose-phosphatase Sugar_tr PF00083.24 KOS23367.1 - 1.3e-129 433.0 23.2 1.5e-129 432.8 23.2 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 KOS23367.1 - 1.1e-21 77.1 43.1 1.4e-14 53.8 16.7 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 KOS23367.1 - 2.7e-05 23.2 13.5 0.0025 16.8 8.0 2.2 2 0 0 2 2 2 2 MFS_1 like family Aconitase PF00330.20 KOS23368.1 - 4e-149 497.5 0.0 5e-149 497.2 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 KOS23368.1 - 3.1e-42 144.0 0.0 5.5e-42 143.2 0.0 1.4 1 0 0 1 1 1 1 Aconitase C-terminal domain PAS_6 PF08348.11 KOS23368.1 - 0.074 12.9 0.3 2.7 7.9 0.0 2.6 2 0 0 2 2 2 0 YheO-like PAS domain B12D PF06522.11 KOS23368.1 - 0.17 11.7 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit zf-C2H2_jaz PF12171.8 KOS23369.1 - 3.1e-09 36.9 0.0 4.8e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-SCNM1 PF15803.5 KOS23369.1 - 0.0053 16.4 0.1 0.01 15.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of sodium channel modifier 1 zf-C2H2_2 PF12756.7 KOS23369.1 - 0.072 13.4 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 KOS23369.1 - 0.077 13.9 0.1 0.17 12.8 0.1 1.6 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.7 KOS23369.1 - 0.14 12.6 0.0 0.27 11.7 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Gaa1 PF04114.14 KOS23370.1 - 6.4e-139 464.2 0.0 8.1e-139 463.8 0.0 1.0 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Rhomboid PF01694.22 KOS23371.1 - 6.9e-14 52.1 10.4 9.7e-14 51.6 10.4 1.1 1 0 0 1 1 1 1 Rhomboid family Ost4 PF10215.9 KOS23371.1 - 0.42 10.5 2.3 2.2 8.2 0.2 2.8 2 1 0 2 2 2 0 Oligosaccaryltransferase HIT PF01230.23 KOS23372.1 - 6.3e-22 78.2 0.2 7.8e-22 77.9 0.2 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 KOS23372.1 - 3.9e-14 53.1 0.1 5.2e-14 52.7 0.1 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 KOS23372.1 - 6e-06 26.1 0.0 8.9e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 ICAT PF06384.11 KOS23372.1 - 0.058 13.7 0.0 0.091 13.0 0.0 1.3 1 0 0 1 1 1 0 Beta-catenin-interacting protein ICAT Mog1 PF04603.12 KOS23373.1 - 3.2e-29 102.0 0.0 4e-29 101.7 0.0 1.1 1 0 0 1 1 1 1 Ran-interacting Mog1 protein DASH_Dam1 PF08653.10 KOS23374.1 - 9.6e-27 92.6 2.6 1.3e-26 92.2 2.6 1.2 1 0 0 1 1 1 1 DASH complex subunit Dam1 CRAL_TRIO PF00650.20 KOS23375.1 - 3.8e-44 150.2 0.0 1.2e-43 148.5 0.0 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 KOS23375.1 - 1.6e-14 53.8 0.1 6.5e-14 51.9 0.1 2.0 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 KOS23375.1 - 9.5e-08 32.3 0.0 3.5e-07 30.5 0.0 1.8 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain DNA_pol_A_exoN PF18305.1 KOS23375.1 - 0.031 14.6 0.3 0.081 13.2 0.1 1.8 2 0 0 2 2 2 0 3' to 5' exonuclease C-terminal domain Peptidase_M29 PF02073.15 KOS23375.1 - 0.036 12.8 0.1 0.062 12.1 0.1 1.3 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) Flg_hook PF02120.16 KOS23375.1 - 0.062 13.2 0.2 2.6 8.0 0.0 3.1 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK SprT-like PF10263.9 KOS23376.1 - 1.1e-40 138.0 0.5 2.6e-40 136.8 0.5 1.6 1 0 0 1 1 1 1 SprT-like family Zn_ribbon_SprT PF17283.2 KOS23376.1 - 4e-09 36.2 4.4 7.2e-09 35.4 4.4 1.5 1 0 0 1 1 1 1 SprT-like zinc ribbon domain HMG_box PF00505.19 KOS23376.1 - 1.1e-05 25.8 0.7 3.1e-05 24.3 0.7 1.8 1 0 0 1 1 1 1 HMG (high mobility group) box Zn-ribbon_8 PF09723.10 KOS23376.1 - 0.0069 16.5 1.0 0.016 15.3 1.0 1.6 1 0 0 1 1 1 1 Zinc ribbon domain YABBY PF04690.13 KOS23376.1 - 0.016 15.8 0.3 0.056 14.0 0.0 1.7 1 1 0 1 1 1 0 YABBY protein HMG_box_2 PF09011.10 KOS23376.1 - 0.035 14.7 0.2 0.088 13.4 0.2 1.6 1 0 0 1 1 1 0 HMG-box domain Peptidase_M90 PF06167.12 KOS23376.1 - 0.047 13.3 0.2 0.075 12.6 0.2 1.3 1 0 0 1 1 1 0 Glucose-regulated metallo-peptidase M90 DUF4379 PF14311.6 KOS23376.1 - 0.13 12.6 3.8 0.56 10.6 3.8 2.2 1 0 0 1 1 1 0 Probable Zinc-ribbon domain Glucan_synthase PF02364.15 KOS23377.1 - 0 1373.9 0.0 0 1373.4 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 KOS23377.1 - 3e-41 140.8 1.7 1e-40 139.0 1.7 2.0 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Sigma_reg_N PF13800.6 KOS23377.1 - 0.22 11.8 1.2 11 6.3 0.1 3.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Aminotran_1_2 PF00155.21 KOS23378.1 - 9.3e-37 127.0 0.0 1.1e-36 126.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Coatomer_WDAD PF04053.14 KOS23379.1 - 2.1e-145 485.2 0.0 3.7e-145 484.4 0.0 1.4 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 KOS23379.1 - 5.1e-95 318.6 0.0 7.1e-95 318.1 0.0 1.1 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 KOS23379.1 - 2.8e-36 122.9 14.9 2.5e-07 31.3 0.2 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 KOS23379.1 - 3.7e-09 36.8 1.2 0.00072 19.8 0.0 5.8 3 2 5 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 KOS23379.1 - 0.055 12.1 6.4 5.2 5.6 0.0 3.9 2 1 1 4 4 4 0 Nucleoporin Nup120/160 Glyco_transf_24 PF18404.1 KOS23380.1 - 1.9e-148 493.1 1.5 2.8e-148 492.6 1.5 1.3 1 0 0 1 1 1 1 Glucosyltransferase 24 Thioredoxin_15 PF18403.1 KOS23380.1 - 1.6e-52 178.6 0.1 6.5e-51 173.3 0.1 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 KOS23380.1 - 1.5e-39 134.5 0.0 2.9e-39 133.5 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_14 PF18402.1 KOS23380.1 - 1.7e-14 54.4 0.0 1.9e-12 47.7 0.0 2.2 2 0 0 2 2 2 2 Thioredoxin-like domain Glyco_transf_8 PF01501.20 KOS23380.1 - 1e-05 25.3 0.1 3.4e-05 23.5 0.1 1.8 2 1 0 2 2 2 1 Glycosyl transferase family 8 FUSC_2 PF13515.6 KOS23381.1 - 6.6e-26 90.9 7.7 6.6e-26 90.9 7.7 2.8 2 1 0 2 2 2 1 Fusaric acid resistance protein-like FUSC PF04632.12 KOS23381.1 - 2.5e-09 36.2 0.1 2.5e-09 36.2 0.1 2.6 3 0 0 3 3 3 1 Fusaric acid resistance protein family ALMT PF11744.8 KOS23381.1 - 0.00079 18.4 9.1 0.0086 15.0 8.9 2.5 2 1 0 2 2 2 1 Aluminium activated malate transporter ArAE_2_N PF10337.9 KOS23381.1 - 0.0016 17.6 0.4 0.0034 16.5 0.4 1.5 1 0 0 1 1 1 1 Putative ER transporter, 6TM, N-terminal FUSC-like PF12805.7 KOS23381.1 - 0.036 13.2 6.4 0.55 9.3 1.6 2.5 2 0 0 2 2 2 0 FUSC-like inner membrane protein yccS Phage_holin_Dp1 PF16938.5 KOS23381.1 - 0.099 12.9 0.1 0.88 9.8 0.0 2.4 2 0 0 2 2 2 0 Putative phage holin Dp-1 ArAE_2 PF10334.9 KOS23381.1 - 0.11 12.3 0.5 2.2 8.0 0.0 2.8 3 1 0 3 3 3 0 Aromatic acid exporter family member 2 DNA_pol_E_B PF04042.16 KOS23382.1 - 1.6e-63 213.8 0.0 2.5e-63 213.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Fibrillarin_2 PF10113.9 KOS23382.1 - 0.29 9.7 0.0 0.45 9.1 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein Pkinase PF00069.25 KOS23383.1 - 2.2e-49 168.2 0.0 3.2e-49 167.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS23383.1 - 9.3e-32 110.3 0.1 1.8e-31 109.4 0.0 1.4 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 KOS23383.1 - 0.00013 20.9 0.0 0.00018 20.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 KOS23383.1 - 0.00063 19.1 0.0 0.0013 18.1 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 KOS23383.1 - 0.0015 17.5 0.1 0.0018 17.3 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 KOS23383.1 - 0.041 12.9 0.3 0.065 12.3 0.1 1.4 1 1 0 1 1 1 0 Seadornavirus VP7 RIO1 PF01163.22 KOS23383.1 - 0.077 12.6 0.1 0.23 11.0 0.2 1.8 1 1 0 1 1 1 0 RIO1 family HAD_2 PF13419.6 KOS23384.1 - 1e-11 45.2 0.0 2e-10 41.1 0.0 2.1 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 KOS23384.1 - 1.5e-11 45.0 0.0 2.5e-08 34.4 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 KOS23384.1 - 6.8e-07 29.3 0.6 2.1e-06 27.7 0.4 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like HAD PF12710.7 KOS23384.1 - 0.00088 19.7 0.3 0.011 16.1 0.3 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 KOS23384.1 - 0.07 12.7 0.0 1.6 8.3 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial PGP phosphatase zf-HIT PF04438.16 KOS23385.1 - 6e-10 38.8 7.6 8.9e-10 38.3 7.6 1.3 1 0 0 1 1 1 1 HIT zinc finger SSP160 PF06933.11 KOS23385.1 - 4 5.5 4.5 5.6 5.0 4.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 EF-hand_4 PF12763.7 KOS23386.1 - 3.9e-37 126.4 0.0 3.4e-16 59.1 0.0 3.4 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 KOS23386.1 - 2.2e-08 34.4 0.0 0.00028 21.3 0.0 4.1 4 0 0 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 KOS23386.1 - 1e-07 30.9 0.0 0.22 11.2 0.1 5.0 5 0 0 5 5 5 1 EF hand EF-hand_6 PF13405.6 KOS23386.1 - 5.3e-07 29.1 0.2 0.11 12.5 0.1 5.1 5 0 0 5 5 4 1 EF-hand domain UBA PF00627.31 KOS23386.1 - 3.5e-06 26.8 0.0 7.2e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Golgin_A5 PF09787.9 KOS23386.1 - 0.0049 16.4 21.7 0.011 15.3 21.7 1.4 1 0 0 1 1 1 1 Golgin subfamily A member 5 Myosin_tail_1 PF01576.19 KOS23386.1 - 0.0092 13.9 24.6 0.013 13.3 24.6 1.1 1 0 0 1 1 1 1 Myosin tail Tup_N PF08581.10 KOS23386.1 - 0.015 15.6 8.3 0.015 15.6 8.3 2.6 1 1 1 2 2 2 0 Tup N-terminal TPR_MLP1_2 PF07926.12 KOS23386.1 - 0.016 15.3 29.2 0.75 9.9 8.6 3.1 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein IFT57 PF10498.9 KOS23386.1 - 0.035 13.1 17.2 0.057 12.4 17.2 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 EF-hand_8 PF13833.6 KOS23386.1 - 0.13 12.1 0.0 7.5 6.5 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair CCDC144C PF14915.6 KOS23386.1 - 0.31 10.1 24.9 0.57 9.2 24.9 1.4 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region GAS PF13851.6 KOS23386.1 - 0.4 10.0 29.0 0.12 11.7 5.9 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FlxA PF14282.6 KOS23386.1 - 0.4 10.7 36.5 0.76 9.8 19.3 2.7 1 1 1 2 2 2 0 FlxA-like protein SOGA PF11365.8 KOS23386.1 - 0.47 11.6 16.1 6 8.1 0.6 2.9 1 1 1 2 2 2 0 Protein SOGA CENP-F_leu_zip PF10473.9 KOS23386.1 - 0.49 10.4 26.2 0.46 10.5 9.8 2.7 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_13 PF13166.6 KOS23386.1 - 0.5 9.0 19.1 0.024 13.3 8.5 2.1 1 1 1 2 2 2 0 AAA domain APG6_N PF17675.1 KOS23386.1 - 0.59 10.7 31.4 6.6 7.3 17.1 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region zf-C4H2 PF10146.9 KOS23386.1 - 0.96 9.7 25.9 2.4 8.4 19.2 3.1 2 1 0 2 2 1 0 Zinc finger-containing protein DUF3584 PF12128.8 KOS23386.1 - 1.1 6.6 28.0 1.6 6.2 28.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 KOS23386.1 - 1.2 9.6 28.1 0.08 13.4 6.6 2.2 1 1 1 2 2 2 0 Fez1 Spc7 PF08317.11 KOS23386.1 - 1.6 7.5 27.1 4.6 6.0 12.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein FUSC PF04632.12 KOS23386.1 - 1.7 7.1 10.7 2.7 6.4 10.7 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family ADIP PF11559.8 KOS23386.1 - 1.7 8.7 34.5 4.2 7.4 7.0 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding MAD PF05557.13 KOS23386.1 - 1.8 6.8 28.8 4.7 5.4 28.8 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein MbeD_MobD PF04899.12 KOS23386.1 - 2.5 8.3 17.9 3.6 7.8 0.2 4.5 3 1 1 4 4 4 0 MbeD/MobD like Filament PF00038.21 KOS23386.1 - 2.7 7.5 26.3 19 4.7 6.2 2.5 1 1 1 2 2 2 0 Intermediate filament protein PRKG1_interact PF15898.5 KOS23386.1 - 3.2 8.7 28.2 0.25 12.3 4.4 3.6 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain EzrA PF06160.12 KOS23386.1 - 4.1 5.4 17.4 7.2 4.6 17.4 1.3 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Occludin_ELL PF07303.13 KOS23386.1 - 6 7.6 13.8 6.4 7.6 0.4 2.6 1 1 0 2 2 2 0 Occludin homology domain LPP PF04728.13 KOS23386.1 - 6 7.3 16.6 6.1 7.3 3.8 4.1 3 1 2 5 5 5 0 Lipoprotein leucine-zipper BRE1 PF08647.11 KOS23386.1 - 6.9 6.8 19.9 12 6.0 1.7 2.6 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TMF_TATA_bd PF12325.8 KOS23386.1 - 7.1 6.9 24.7 13 6.1 1.9 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Mod_r PF07200.13 KOS23386.1 - 7.6 6.6 28.4 0.51 10.4 9.6 3.1 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4200 PF13863.6 KOS23386.1 - 9.7 6.6 22.1 11 6.4 3.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Sec6 PF06046.13 KOS23387.1 - 2.6e-165 551.1 6.4 2.6e-165 551.1 6.4 1.6 2 0 0 2 2 2 1 Exocyst complex component Sec6 FAD_binding_2 PF00890.24 KOS23387.1 - 0.00036 19.7 0.1 0.0013 17.9 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain Vps53_N PF04100.12 KOS23387.1 - 0.0019 17.3 4.2 0.0061 15.6 2.4 2.6 1 1 1 2 2 2 1 Vps53-like, N-terminal OmdA PF13376.6 KOS23387.1 - 0.0025 17.8 0.5 0.043 13.8 0.0 2.8 2 0 0 2 2 2 1 Bacteriocin-protection, YdeI or OmpD-Associated DUF755 PF05501.11 KOS23387.1 - 0.26 11.6 0.9 0.48 10.7 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) FadA PF09403.10 KOS23387.1 - 0.33 11.4 5.6 2.6 8.6 1.2 3.1 2 0 0 2 2 2 0 Adhesion protein FadA DUF2018 PF09442.10 KOS23387.1 - 0.41 11.6 3.6 0.52 11.3 0.4 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF2018) Ferritin PF00210.24 KOS23387.1 - 0.62 10.0 4.8 0.84 9.6 0.2 3.3 3 1 0 3 3 3 0 Ferritin-like domain Sec20 PF03908.13 KOS23387.1 - 0.84 9.6 3.9 1.6 8.7 0.9 3.0 3 1 1 4 4 4 0 Sec20 ACP_PD PF04336.12 KOS23387.1 - 0.84 10.1 4.3 10 6.6 0.5 4.0 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase DUF3829 PF12889.7 KOS23387.1 - 1.3 8.5 6.7 0.31 10.5 1.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) DUF2205 PF10224.9 KOS23387.1 - 1.9 8.5 9.9 5.1 7.2 0.6 4.1 4 0 0 4 4 4 0 Short coiled-coil protein CENP-O PF09496.10 KOS23387.1 - 2.3 8.2 5.0 0.61 10.0 1.4 1.9 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component DUF327 PF03885.13 KOS23387.1 - 3.7 7.5 7.2 3.4 7.6 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF327) N_BRCA1_IG PF16158.5 KOS23389.1 - 7.8e-33 113.3 0.0 1.8e-32 112.1 0.0 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 KOS23389.1 - 2.2e-08 33.8 17.3 0.00011 21.9 5.8 2.8 3 0 0 3 3 3 2 Zinc finger, ZZ type zf-UBR PF02207.20 KOS23389.1 - 0.38 10.9 7.0 3.2 8.0 0.3 2.4 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) WD40 PF00400.32 KOS23390.1 - 7.2e-14 52.0 4.7 8.6e-06 26.4 0.0 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF4831 PF16115.5 KOS23390.1 - 0.17 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4831) ADH_zinc_N PF00107.26 KOS23391.1 - 9.6e-29 100.0 0.1 1.7e-28 99.2 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 KOS23391.1 - 6.4e-11 43.4 0.0 1.2e-10 42.6 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 KOS23391.1 - 1.9e-06 27.7 0.0 1.5e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain RAMA PF18755.1 KOS23391.1 - 0.07 13.6 0.0 5.3 7.5 0.0 2.4 2 0 0 2 2 2 0 Restriction Enzyme Adenine Methylase Associated ABC_membrane PF00664.23 KOS23392.1 - 3.3e-41 141.8 12.7 4.2e-41 141.4 12.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region BatA PF07584.11 KOS23392.1 - 0.072 13.5 3.2 3.2 8.2 0.4 2.7 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF3742 PF12553.8 KOS23392.1 - 2.1 8.5 8.4 1.4 9.1 0.4 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF3742) ABC_membrane PF00664.23 KOS23393.1 - 3.6e-33 115.4 1.3 4.8e-33 115.0 1.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 KOS23393.1 - 2.1e-29 102.8 0.0 3.2e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 KOS23393.1 - 3.6e-06 26.6 0.0 0.0093 15.4 0.0 2.3 1 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 KOS23393.1 - 0.0003 20.5 0.0 0.00065 19.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 KOS23393.1 - 0.00086 19.2 0.0 0.56 10.0 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 KOS23393.1 - 0.0027 17.7 0.0 0.005 16.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 KOS23393.1 - 0.0042 17.5 0.0 0.016 15.6 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain ABC_membrane_3 PF13748.6 KOS23393.1 - 0.0069 15.7 0.2 0.012 14.8 0.2 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region MMR_HSR1 PF01926.23 KOS23393.1 - 0.0089 16.1 0.0 0.023 14.8 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 KOS23393.1 - 0.011 16.0 0.0 0.046 14.0 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_ATPase PF09818.9 KOS23393.1 - 0.013 14.4 0.2 0.17 10.7 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_25 PF13481.6 KOS23393.1 - 0.025 14.1 0.0 0.69 9.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain 5_3_exonuc_N PF02739.16 KOS23393.1 - 0.04 13.8 0.3 0.083 12.8 0.1 1.6 2 0 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain AAA_23 PF13476.6 KOS23393.1 - 0.045 14.2 0.0 0.077 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain tRNA_anti-like PF12869.7 KOS23393.1 - 0.062 12.9 0.3 0.2 11.2 0.0 1.9 2 0 0 2 2 2 0 tRNA_anti-like AAA_15 PF13175.6 KOS23393.1 - 0.13 12.0 0.0 0.32 10.7 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Rad17 PF03215.15 KOS23393.1 - 0.17 11.8 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Cation_ATPase_C PF00689.21 KOS23394.1 - 5e-41 140.4 2.2 5e-41 140.4 2.2 2.9 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 KOS23394.1 - 2.2e-33 115.3 1.0 2.2e-33 115.3 1.0 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Cation_ATPase PF13246.6 KOS23394.1 - 1.9e-20 72.7 0.0 4.2e-20 71.6 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 KOS23394.1 - 1.3e-14 55.0 0.2 6.6e-12 46.2 0.0 2.5 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 KOS23394.1 - 1e-07 31.5 0.3 3.6e-07 29.8 0.0 2.1 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 KOS23394.1 - 4.2e-05 23.4 0.2 0.0011 18.8 0.5 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase STE3 PF02076.15 KOS23394.1 - 0.15 11.3 6.3 0.67 9.1 0.1 3.2 3 0 0 3 3 3 0 Pheromone A receptor Abhydrolase_9_N PF15420.6 KOS23394.1 - 2.8 7.9 8.2 3 7.8 0.4 2.9 3 0 0 3 3 3 0 Alpha/beta-hydrolase family N-terminus DUF3810 PF12725.7 KOS23394.1 - 6.1 6.1 5.7 0.65 9.3 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) NUP PF06516.11 KOS23395.1 - 1.8e-123 411.7 0.0 2.1e-123 411.5 0.0 1.0 1 0 0 1 1 1 1 Purine nucleoside permease (NUP) Pkinase PF00069.25 KOS23396.1 - 2.3e-43 148.5 0.0 1.1e-42 146.2 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 KOS23396.1 - 1e-30 106.9 0.0 1.5e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 KOS23396.1 - 0.00021 20.7 0.0 0.0039 16.6 0.0 2.1 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 KOS23396.1 - 0.0015 17.9 0.0 0.0026 17.1 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 KOS23396.1 - 0.046 13.6 0.0 0.35 10.8 0.0 2.3 2 1 1 3 3 3 0 Phosphotransferase enzyme family PK PF00224.21 KOS23397.1 - 2.4e-171 569.3 3.8 2.9e-171 569.0 3.8 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 KOS23397.1 - 2.4e-37 127.7 0.0 1.2e-36 125.4 0.0 2.2 3 0 0 3 3 3 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 KOS23397.1 - 3e-05 23.2 0.7 8.1e-05 21.9 0.3 1.8 1 1 1 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMPDH PF00478.25 KOS23397.1 - 0.05 12.6 0.0 0.37 9.7 0.0 2.0 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain DUF1748 PF08520.10 KOS23398.1 - 9.8e-34 115.1 0.1 1.1e-33 114.9 0.1 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Syntaxin-6_N PF09177.11 KOS23399.1 - 0.0084 16.6 0.5 4.4 7.9 0.0 2.6 2 0 0 2 2 2 2 Syntaxin 6, N-terminal Nrap_D4 PF17405.2 KOS23399.1 - 0.087 12.2 0.2 0.15 11.4 0.2 1.3 1 0 0 1 1 1 0 Nrap protein nucleotidyltransferase domain 4 RasGAP_C PF03836.15 KOS23399.1 - 0.13 12.5 1.0 0.64 10.2 0.1 2.3 2 0 0 2 2 2 0 RasGAP C-terminus Spc7 PF08317.11 KOS23399.1 - 0.36 9.7 6.6 0.67 8.8 1.7 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein Filament PF00038.21 KOS23399.1 - 0.58 9.7 5.9 0.29 10.7 0.7 2.3 2 0 0 2 2 2 0 Intermediate filament protein APG6_N PF17675.1 KOS23399.1 - 1 9.9 16.8 1.3 9.5 7.6 4.1 3 1 1 4 4 4 0 Apg6 coiled-coil region Fez1 PF06818.15 KOS23399.1 - 1.7 9.1 5.7 0.66 10.4 0.7 2.2 1 1 1 2 2 2 0 Fez1 Methyltransf_34 PF11312.8 KOS23400.1 - 1.9e-104 349.2 0.0 2.3e-104 348.9 0.0 1.1 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase PWWP PF00855.17 KOS23401.1 - 0.046 14.1 0.0 0.063 13.7 0.0 1.2 1 0 0 1 1 1 0 PWWP domain Btz PF09405.10 KOS23402.1 - 4.3e-26 91.7 0.4 1.1e-25 90.4 0.4 1.7 1 0 0 1 1 1 1 CASC3/Barentsz eIF4AIII binding Syja_N PF02383.18 KOS23403.1 - 1.1e-48 166.2 0.0 1.3e-29 103.5 0.0 2.2 1 1 1 2 2 2 2 SacI homology domain hSac2 PF12456.8 KOS23403.1 - 3.2e-36 123.5 0.0 6e-36 122.7 0.0 1.4 1 0 0 1 1 1 1 Inositol phosphatase Arch_flagellin PF01917.16 KOS23403.1 - 0.14 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Archaebacterial flagellin Lipase_GDSL PF00657.22 KOS23403.1 - 0.15 12.1 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Pox_Ag35 PF03286.14 KOS23403.1 - 1 9.1 4.9 2.1 8.1 4.9 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 KOS23403.1 - 2.4 7.4 5.4 4.7 6.5 5.4 1.4 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 KOS23403.1 - 4.1 7.1 5.4 8 6.1 5.4 1.4 1 0 0 1 1 1 0 FAM176 family TFIIA PF03153.13 KOS23403.1 - 6 6.7 8.0 9.7 6.1 8.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Fungal_trans_2 PF11951.8 KOS23404.1 - 0.0001 21.2 0.0 0.00014 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain PAF-AH_p_II PF03403.13 KOS23405.1 - 1.6e-16 59.8 0.0 1.1e-08 34.0 0.0 2.1 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Chlorophyllase2 PF12740.7 KOS23405.1 - 8.4e-08 31.4 0.0 1.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Hydrolase_4 PF12146.8 KOS23405.1 - 8.2e-05 22.0 0.0 0.25 10.6 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 KOS23405.1 - 0.0024 17.7 0.0 1.8 8.3 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Chlorophyllase PF07224.11 KOS23405.1 - 0.0075 15.3 0.0 0.63 9.0 0.0 2.1 2 0 0 2 2 2 2 Chlorophyllase Abhydrolase_1 PF00561.20 KOS23405.1 - 0.027 14.1 0.1 0.72 9.4 0.0 2.1 2 0 0 2 2 2 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 KOS23405.1 - 0.15 11.5 0.1 0.62 9.5 0.0 1.9 2 0 0 2 2 2 0 Prolyl oligopeptidase family ATP-synt_C PF00137.21 KOS23406.1 - 8.6e-35 118.9 34.0 7.7e-22 77.4 14.6 2.1 2 0 0 2 2 2 2 ATP synthase subunit C ERG4_ERG24 PF01222.17 KOS23407.1 - 1.1e-135 452.7 20.5 1.3e-135 452.5 20.5 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DTHCT PF08070.11 KOS23407.1 - 0.62 10.8 3.7 1.1 10.1 3.7 1.3 1 0 0 1 1 1 0 DTHCT (NUC029) region ORC6 PF05460.13 KOS23407.1 - 5.3 6.2 5.5 7.6 5.7 5.5 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Glyco_hydro_18 PF00704.28 KOS23408.1 - 7.8e-64 216.4 0.0 9.1e-64 216.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 ANAPC4_WD40 PF12894.7 KOS23409.1 - 4.4e-06 26.9 0.0 0.00066 19.9 0.0 3.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Sporozoite_P67 PF05642.11 KOS23409.1 - 0.00059 18.1 7.1 0.0029 15.8 4.7 2.2 2 0 0 2 2 2 1 Sporozoite P67 surface antigen CDC45 PF02724.14 KOS23409.1 - 0.0014 17.0 18.7 0.0014 17.0 18.7 1.6 2 0 0 2 2 2 1 CDC45-like protein Nup160 PF11715.8 KOS23409.1 - 0.013 14.2 0.0 0.022 13.4 0.0 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Prothymosin PF03247.14 KOS23409.1 - 0.019 15.4 21.6 0.019 15.4 21.6 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family WD40 PF00400.32 KOS23409.1 - 0.02 15.7 7.2 7 7.7 0.0 4.9 6 0 0 6 6 6 0 WD domain, G-beta repeat YL1 PF05764.13 KOS23409.1 - 4.1 7.4 23.6 0.98 9.5 18.7 2.0 2 0 0 2 2 2 0 YL1 nuclear protein CDC27 PF09507.10 KOS23409.1 - 4.2 6.6 20.1 0.11 11.8 13.6 1.5 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 SURF2 PF05477.11 KOS23409.1 - 4.4 6.9 12.6 47 3.6 12.0 2.0 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) DUF913 PF06025.12 KOS23409.1 - 5.4 5.9 4.5 8.8 5.2 4.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DHHC PF01529.20 KOS23410.1 - 2.8e-29 101.9 1.1 3.1e-29 101.8 0.2 1.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase Ribosomal_L40e PF01020.17 KOS23410.1 - 0.081 12.8 7.3 0.2 11.6 7.3 1.6 1 0 0 1 1 1 0 Ribosomal L40e family DZR PF12773.7 KOS23410.1 - 0.32 11.1 7.3 0.58 10.2 7.3 1.3 1 0 0 1 1 1 0 Double zinc ribbon Glyco_transf_90 PF05686.12 KOS23411.1 - 3.1e-07 29.7 0.0 0.0025 16.8 0.1 3.5 3 1 0 3 3 3 2 Glycosyl transferase family 90 SWIRM-assoc_2 PF16496.5 KOS23412.1 - 0.015 14.2 0.0 0.015 14.2 0.0 3.6 4 0 0 4 4 4 0 SWIRM-associated domain at the N-terminal PTCB-BRCT PF12738.7 KOS23412.1 - 0.06 13.3 0.4 0.72 9.8 0.4 2.3 1 1 0 1 1 1 0 twin BRCT domain Med3 PF11593.8 KOS23413.1 - 5.1 6.2 9.6 5.2 6.1 9.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Oxidored_molyb PF00174.19 KOS23414.1 - 8.2e-55 185.0 0.0 2e-54 183.8 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 KOS23414.1 - 1.2e-35 122.6 0.1 3.7e-35 120.9 0.1 1.9 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain NAD_binding_1 PF00175.21 KOS23414.1 - 2e-21 76.7 0.1 1.7e-20 73.7 0.0 2.7 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 KOS23414.1 - 6.9e-18 64.8 0.0 3.8e-16 59.2 0.0 2.5 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain Cyt-b5 PF00173.28 KOS23414.1 - 6.3e-15 55.1 0.1 1.6e-14 53.8 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF5094 PF17015.5 KOS23414.1 - 1.1 9.3 8.9 3.1 7.9 8.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) SprA-related PF12118.8 KOS23414.1 - 8.8 5.4 10.7 15 4.6 10.7 1.3 1 0 0 1 1 1 0 SprA-related family FKBP_C PF00254.28 KOS23415.1 - 7.7e-33 112.7 0.0 9.8e-33 112.3 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase RPEL PF02755.15 KOS23416.1 - 2.7e-17 61.8 5.0 5e-08 32.4 0.5 2.4 2 0 0 2 2 2 2 RPEL repeat Paramyxo_C PF01692.18 KOS23416.1 - 0.023 14.1 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C Myosin_head PF00063.21 KOS23417.1 - 1.9e-239 796.4 2.7 2.3e-239 796.1 2.7 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 KOS23417.1 - 6.8e-51 172.6 0.0 1.2e-50 171.8 0.0 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 KOS23417.1 - 7.2e-12 44.7 0.3 1.6e-11 43.6 0.3 1.7 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 KOS23417.1 - 7.5e-09 35.3 0.0 1.9e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 KOS23417.1 - 1.9e-07 30.6 0.0 5.6e-07 29.1 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain IQ PF00612.27 KOS23417.1 - 0.0051 16.5 10.0 0.17 11.8 2.4 2.7 1 1 1 2 2 2 2 IQ calmodulin-binding motif Hpr_kinase_C PF07475.12 KOS23417.1 - 0.023 14.2 0.2 3.7 7.0 0.0 2.4 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 KOS23417.1 - 0.057 13.7 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 KOS23417.1 - 0.078 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain SepF PF04472.12 KOS23417.1 - 0.082 13.2 0.1 0.29 11.4 0.0 2.0 2 0 0 2 2 1 0 Cell division protein SepF AAA_16 PF13191.6 KOS23417.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activat PF00158.26 KOS23417.1 - 0.17 11.6 0.0 0.32 10.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF4913 PF16259.5 KOS23417.1 - 0.22 11.6 1.5 0.55 10.3 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) DAHP_synth_2 PF01474.16 KOS23418.1 - 1.7e-200 666.1 0.0 1.9e-200 666.0 0.0 1.0 1 0 0 1 1 1 1 Class-II DAHP synthetase family Aldose_epim PF01263.20 KOS23419.1 - 9.4e-38 130.2 0.0 1.1e-37 130.0 0.0 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Peptidase_M24 PF00557.24 KOS23420.1 - 1.3e-49 168.8 0.1 1.5e-49 168.5 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 KOS23420.1 - 2.3e-21 75.8 9.7 4.4e-21 74.9 9.7 1.5 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 KOS23420.1 - 0.00012 22.0 5.0 0.00012 22.0 5.0 2.1 2 0 0 2 2 2 1 MYND finger DUF3506 PF12014.8 KOS23421.1 - 6.4e-54 181.7 0.0 2e-53 180.1 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3506) F-box-like PF12937.7 KOS23421.1 - 1.9e-05 24.4 0.1 3.7e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 KOS23421.1 - 0.00011 22.0 0.0 0.00028 20.7 0.0 1.7 1 0 0 1 1 1 1 F-box domain Serglycin PF04360.12 KOS23421.1 - 0.15 12.0 2.0 0.3 11.0 2.0 1.5 1 0 0 1 1 1 0 Serglycin FAD_binding_3 PF01494.19 KOS23423.1 - 1.6e-09 37.5 0.0 2.4e-08 33.6 0.0 2.1 1 1 0 1 1 1 1 FAD binding domain Ribosomal_S8 PF00410.19 KOS23423.1 - 3.1e-09 36.9 0.0 5.6e-08 32.8 0.0 2.3 1 1 0 1 1 1 1 Ribosomal protein S8 SE PF08491.10 KOS23423.1 - 0.12 11.5 0.0 0.27 10.3 0.0 1.5 1 0 0 1 1 1 0 Squalene epoxidase Asp PF00026.23 KOS23424.1 - 5e-52 177.3 0.8 2.2e-41 142.3 0.1 2.2 1 1 1 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 KOS23424.1 - 6.7e-09 36.2 1.3 0.0011 19.2 0.0 2.7 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 KOS23424.1 - 0.0005 20.6 0.1 0.47 11.0 0.0 3.5 3 0 0 3 3 3 2 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 KOS23424.1 - 0.013 16.2 3.9 0.52 11.0 0.1 3.6 3 1 1 4 4 4 0 Aspartyl protease GTP_EFTU PF00009.27 KOS23425.1 - 4.5e-59 199.3 0.1 8.3e-59 198.4 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 KOS23425.1 - 2.7e-32 111.1 0.0 6e-32 110.0 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 KOS23425.1 - 2.9e-32 110.6 0.0 6.4e-32 109.5 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 KOS23425.1 - 1.2e-22 79.8 0.0 2.5e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 KOS23425.1 - 1.2e-13 51.2 0.0 2.9e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 KOS23425.1 - 1.1e-06 28.6 0.0 2.2e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain AvrPtoB_bdg PF16847.5 KOS23425.1 - 0.15 12.5 0.0 3 8.4 0.0 2.4 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain ABC2_membrane PF01061.24 KOS23426.1 - 3.7e-39 134.3 16.8 3.7e-39 134.3 16.8 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 KOS23426.1 - 7.3e-25 88.1 0.0 1.6e-24 87.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOS23426.1 - 3.3e-05 23.9 0.0 0.24 11.1 0.1 2.5 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system ABC2_membrane_3 PF12698.7 KOS23426.1 - 4.4e-05 22.8 18.0 4.4e-05 22.8 18.0 2.1 1 1 1 2 2 2 1 ABC-2 family transporter protein AAA_29 PF13555.6 KOS23426.1 - 0.0053 16.5 0.1 0.013 15.2 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 KOS23426.1 - 0.0093 15.9 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 KOS23426.1 - 0.011 16.3 0.0 0.021 15.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 KOS23426.1 - 0.029 13.9 0.0 0.06 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 KOS23426.1 - 0.058 12.8 0.0 0.61 9.5 0.0 2.3 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain NACHT PF05729.12 KOS23426.1 - 0.06 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_23 PF13476.6 KOS23426.1 - 0.093 13.2 0.1 0.19 12.2 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 KOS23426.1 - 0.14 12.4 0.0 0.27 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 KOS23426.1 - 0.14 12.5 0.0 0.31 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain PDR_CDR PF06422.12 KOS23426.1 - 0.14 12.0 0.9 0.53 10.2 0.0 2.5 2 0 0 2 2 2 0 CDR ABC transporter Aminotran_1_2 PF00155.21 KOS23427.1 - 5.6e-42 144.2 0.0 7.3e-42 143.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 KOS23427.1 - 2.3e-07 30.4 0.0 3.7e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 KOS23427.1 - 3.8e-07 29.0 0.0 5.5e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 KOS23427.1 - 7.2e-07 28.5 0.0 1.1e-06 27.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_MocR PF12897.7 KOS23427.1 - 2.7e-06 26.5 0.0 3.9e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Alanine-glyoxylate amino-transferase Alliinase_C PF04864.13 KOS23427.1 - 0.0044 15.9 0.1 0.013 14.4 0.1 1.6 1 1 0 1 1 1 1 Allinase DegT_DnrJ_EryC1 PF01041.17 KOS23427.1 - 0.085 12.1 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family RNase_Zc3h12a PF11977.8 KOS23427.1 - 0.21 11.4 0.0 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 Zc3h12a-like Ribonuclease NYN domain NGP1NT PF08153.12 KOS23428.1 - 5.5e-49 165.6 0.1 8.3e-49 165.1 0.1 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 KOS23428.1 - 5.3e-17 61.9 0.0 7.5e-13 48.6 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 KOS23428.1 - 1.4e-05 25.0 0.0 0.0022 17.9 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 KOS23428.1 - 2.2e-05 24.0 0.0 0.00012 21.7 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 KOS23428.1 - 0.00013 22.1 0.8 0.052 13.6 0.1 3.3 2 1 1 3 3 3 1 Dynamin family GTP_EFTU PF00009.27 KOS23428.1 - 0.00063 19.3 0.1 0.23 11.0 0.0 3.3 3 0 0 3 3 3 1 Elongation factor Tu GTP binding domain Arf PF00025.21 KOS23428.1 - 0.0039 16.7 0.1 1 8.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 KOS23428.1 - 0.056 13.7 0.1 7 6.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Sel1 PF08238.12 KOS23431.1 - 5.2e-12 46.0 24.8 0.00011 22.8 0.0 7.2 7 0 0 7 7 7 5 Sel1 repeat PAT1 PF09770.9 KOS23431.1 - 0.0011 17.4 36.9 0.0017 16.7 36.9 1.2 1 0 0 1 1 1 1 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 KOS23431.1 - 0.0017 18.5 48.6 0.0017 18.5 48.6 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TPR_1 PF00515.28 KOS23431.1 - 0.0062 16.3 0.2 0.02 14.7 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Mitofilin PF09731.9 KOS23431.1 - 0.05 12.4 17.9 0.088 11.6 17.9 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TraI_2B PF18340.1 KOS23431.1 - 0.068 13.3 1.2 0.3 11.2 1.2 2.1 1 1 0 1 1 1 0 DNA relaxase TraI 2B/2B-like domain GREB1 PF15782.5 KOS23431.1 - 0.29 8.2 18.6 0.39 7.8 18.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 KOS23431.1 - 0.58 8.9 26.8 1.1 8.0 26.8 1.3 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 KOS23431.1 - 0.82 8.5 15.2 1.3 7.9 15.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TPR_8 PF13181.6 KOS23431.1 - 1.9 8.9 6.7 1.8 9.0 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Exonuc_VII_L PF02601.15 KOS23431.1 - 2.9 7.4 17.5 4.9 6.6 17.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCSAP PF15748.5 KOS23431.1 - 4.1 7.5 32.9 0.22 11.7 27.1 1.8 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Hid1 PF12722.7 KOS23431.1 - 6.1 4.8 22.4 9 4.3 22.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 KOS23431.1 - 9.7 5.3 18.0 0.18 11.0 11.3 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter Importin_rep_4 PF18808.1 KOS23432.1 - 2.2e-31 108.0 2.0 2.2e-31 108.0 2.0 5.4 5 1 1 6 6 6 1 Importin repeat Importin_rep_5 PF18816.1 KOS23432.1 - 2.6e-22 78.9 6.2 6.1e-22 77.7 2.6 3.4 4 0 0 4 4 3 1 Importin repeat HEAT_EZ PF13513.6 KOS23432.1 - 2e-17 63.3 20.6 6.7e-11 42.5 0.3 9.0 8 1 2 10 10 9 4 HEAT-like repeat HEAT_2 PF13646.6 KOS23432.1 - 2.1e-16 60.1 13.3 1e-07 32.2 0.1 8.1 5 2 4 9 9 8 4 HEAT repeats HEAT PF02985.22 KOS23432.1 - 4.4e-15 54.5 21.6 0.0016 18.5 0.0 12.0 14 0 0 14 14 10 4 HEAT repeat Importin_rep_6 PF18829.1 KOS23432.1 - 2.3e-14 53.5 3.7 8.3e-13 48.4 0.1 3.9 3 0 0 3 3 3 1 Importin repeat 6 Vac14_Fab1_bd PF12755.7 KOS23432.1 - 9.9e-12 45.3 3.3 0.0089 16.6 0.0 8.2 5 3 5 10 10 9 2 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 KOS23432.1 - 2.6e-10 40.3 0.0 0.0023 17.7 0.1 5.5 3 2 2 5 5 5 2 rRNA processing/ribosome biogenesis Cnd1 PF12717.7 KOS23432.1 - 5.8e-08 33.0 3.1 0.095 12.7 0.1 5.9 6 0 0 6 6 5 1 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 KOS23432.1 - 2e-07 31.0 0.8 0.027 14.4 0.0 5.8 4 1 1 6 6 6 1 Domain of unknown function (DUF3385) MMS19_C PF12460.8 KOS23432.1 - 2.5e-07 30.2 8.4 5.9e-07 28.9 0.2 4.5 6 0 0 6 6 6 1 RNAPII transcription regulator C-terminal CLASP_N PF12348.8 KOS23432.1 - 2.9e-07 30.3 1.6 0.0021 17.6 0.4 5.3 6 1 1 7 7 6 1 CLASP N terminal DRIM PF07539.12 KOS23432.1 - 1.9e-05 23.2 6.9 0.0014 17.0 0.5 4.6 3 3 0 4 4 4 1 Down-regulated in metastasis DUF3535 PF12054.8 KOS23432.1 - 0.00077 18.8 1.0 0.0023 17.3 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3535) BP28CT PF08146.12 KOS23432.1 - 0.0008 19.3 6.1 0.89 9.4 0.0 4.8 4 1 0 4 4 4 1 BP28CT (NUC211) domain V-ATPase_H_N PF03224.14 KOS23432.1 - 0.0019 17.5 3.9 0.081 12.2 0.1 3.2 2 1 1 3 3 3 1 V-ATPase subunit H Telomere_reg-2 PF10193.9 KOS23432.1 - 0.0031 17.9 2.0 0.0031 17.9 2.0 4.0 4 1 1 5 5 4 1 Telomere length regulation protein DNA_alkylation PF08713.11 KOS23432.1 - 0.0048 16.6 0.0 0.14 11.9 0.0 2.9 1 1 0 2 2 2 1 DNA alkylation repair enzyme IBN_N PF03810.19 KOS23432.1 - 0.0072 16.2 0.3 0.12 12.3 0.0 3.2 3 0 0 3 3 3 1 Importin-beta N-terminal domain UNC45-central PF11701.8 KOS23432.1 - 0.0082 16.1 4.4 1.2 9.1 0.6 4.0 3 0 0 3 3 3 1 Myosin-binding striated muscle assembly central Arm PF00514.23 KOS23432.1 - 0.0089 16.0 7.8 0.88 9.7 0.0 5.4 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat RTP1_C1 PF10363.9 KOS23432.1 - 0.035 14.3 3.1 0.68 10.1 0.4 4.2 5 1 1 6 6 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF4042 PF13251.6 KOS23432.1 - 0.043 13.5 0.3 18 4.9 0.0 4.7 4 1 2 6 6 6 0 Domain of unknown function (DUF4042) Cohesin_HEAT PF12765.7 KOS23432.1 - 0.046 14.0 0.0 12 6.3 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat associated with sister chromatid cohesion CAS_CSE1 PF03378.15 KOS23432.1 - 0.17 10.3 2.9 2.6 6.4 0.2 3.6 3 1 2 5 5 5 0 CAS/CSE protein, C-terminus CBS PF00571.28 KOS23433.1 - 5.4e-18 65.2 1.5 2.8e-05 24.5 0.0 5.0 5 0 0 5 5 5 4 CBS domain NYN PF01936.18 KOS23434.1 - 0.0055 17.2 0.0 0.0096 16.4 0.0 1.4 1 0 0 1 1 1 1 NYN domain CSN8_PSD8_EIF3K PF10075.9 KOS23435.1 - 1.3e-19 70.6 0.0 2.1e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 KOS23435.1 - 0.11 11.9 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 SAC3/GANP family PAS_9 PF13426.7 KOS23436.1 - 2.5e-23 82.3 0.0 2.1e-18 66.5 0.0 2.5 2 0 0 2 2 2 2 PAS domain PAS_3 PF08447.12 KOS23436.1 - 5.6e-17 61.8 0.0 5.4e-12 45.8 0.0 2.6 2 0 0 2 2 2 2 PAS fold PAS PF00989.25 KOS23436.1 - 1.1e-13 51.1 0.0 1.7e-06 28.0 0.0 3.1 2 1 0 2 2 2 2 PAS fold PAS_4 PF08448.10 KOS23436.1 - 2.4e-05 24.6 0.0 0.0028 17.9 0.0 2.5 2 0 0 2 2 2 1 PAS fold PAS_11 PF14598.6 KOS23436.1 - 0.0012 19.0 0.2 0.0043 17.1 0.0 2.0 2 0 0 2 2 2 1 PAS domain Med8 PF10232.9 KOS23437.1 - 7.4e-39 133.7 5.9 9.5e-39 133.4 5.9 1.1 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription complex subunit 8 Rotamase PF00639.21 KOS23437.1 - 0.0013 19.6 0.0 0.0048 17.8 0.0 2.0 1 1 1 2 2 2 1 PPIC-type PPIASE domain NACHT PF05729.12 KOS23437.1 - 0.0089 16.0 0.9 0.012 15.5 0.9 1.2 1 0 0 1 1 1 1 NACHT domain DUF3245 PF11595.8 KOS23437.1 - 0.062 13.8 3.1 0.11 13.0 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) RasGEF_N_2 PF14663.6 KOS23437.1 - 0.12 12.7 1.3 0.65 10.4 1.3 2.1 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cwf_Cwc_15 PF04889.12 KOS23437.1 - 0.24 11.1 8.4 0.46 10.2 8.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pes-10 PF07149.11 KOS23437.1 - 0.27 10.2 3.7 0.48 9.4 3.8 1.2 1 1 0 1 1 1 0 Pes-10 GCIP PF13324.6 KOS23437.1 - 0.5 9.9 12.5 0.06 12.9 5.3 2.1 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting NOA36 PF06524.12 KOS23437.1 - 2.2 7.5 12.6 3 7.1 12.6 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 KOS23437.1 - 3.4 6.7 15.3 4.8 6.2 15.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 KOS23437.1 - 6.2 7.3 16.9 11 6.4 16.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 KOS23437.1 - 6.6 4.8 10.5 10 4.2 10.5 1.3 1 0 0 1 1 1 0 Nop14-like family Sigma70_r4_2 PF08281.12 KOS23438.1 - 0.013 15.2 0.2 0.024 14.3 0.2 1.4 1 0 0 1 1 1 0 Sigma-70, region 4 ABC_membrane_2 PF06472.15 KOS23439.1 - 7.1e-93 310.9 0.3 7.1e-93 310.9 0.3 1.9 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 KOS23439.1 - 6.8e-16 59.0 0.0 1.4e-15 58.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 KOS23439.1 - 0.002 18.0 0.0 0.0047 16.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 KOS23439.1 - 0.0068 16.9 1.5 1.2 9.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain THOC7 PF05615.13 KOS23439.1 - 0.008 16.5 2.1 0.018 15.3 2.1 1.5 1 0 0 1 1 1 1 Tho complex subunit 7 ALIX_LYPXL_bnd PF13949.6 KOS23439.1 - 0.0099 15.2 0.1 0.016 14.5 0.1 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV RuvB_N PF05496.12 KOS23439.1 - 0.047 13.4 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 KOS23439.1 - 0.074 13.4 0.1 0.21 12.0 0.1 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 KOS23439.1 - 0.14 11.7 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 KOS23439.1 - 0.19 11.1 0.0 0.33 10.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NIF PF03031.18 KOS23440.1 - 4e-54 182.6 0.1 5.6e-54 182.1 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF4597 PF15366.6 KOS23440.1 - 0.057 13.2 3.7 0.086 12.6 1.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4597) Pkinase_Tyr PF07714.17 KOS23441.1 - 0.0014 18.0 0.0 0.22 10.8 0.0 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase RuBisCO_large_N PF02788.16 KOS23441.1 - 0.029 14.5 0.0 2.6 8.3 0.0 2.4 2 0 0 2 2 2 0 Ribulose bisphosphate carboxylase large chain, N-terminal domain Pkinase PF00069.25 KOS23441.1 - 0.15 11.4 0.0 2.9 7.2 0.0 2.1 2 0 0 2 2 2 0 Protein kinase domain Herpes_pp85 PF04637.12 KOS23442.1 - 2.3 6.5 4.8 3.2 6.1 4.8 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) RNase_P_p30 PF01876.16 KOS23443.1 - 2.1e-58 197.3 0.0 3.3e-58 196.7 0.0 1.2 1 0 0 1 1 1 1 RNase P subunit p30 Sulfatase PF00884.23 KOS23444.1 - 2.5e-55 188.0 0.0 2.9e-32 112.3 0.0 2.1 1 1 1 2 2 2 2 Sulfatase Choline_sulf_C PF12411.8 KOS23444.1 - 1.8e-12 46.8 0.1 1.8e-12 46.8 0.1 2.8 3 1 1 4 4 4 1 Choline sulfatase enzyme C terminal Phosphodiest PF01663.22 KOS23444.1 - 2.6e-07 30.5 0.0 8.9e-05 22.2 0.0 2.3 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF229 PF02995.17 KOS23444.1 - 2.2e-05 23.3 0.0 3.3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF229) DUF4994 PF16385.5 KOS23444.1 - 0.0068 16.3 0.0 2.3 8.2 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function DUF4976 PF16347.5 KOS23444.1 - 0.091 13.0 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Sulfatase_C PF14707.6 KOS23444.1 - 0.11 13.2 0.7 0.36 11.6 0.7 1.9 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase AGA2 PF17366.2 KOS23444.1 - 0.21 11.3 0.2 0.43 10.3 0.0 1.6 2 0 0 2 2 2 0 A-agglutinin-binding subunit Aga2 DUF1501 PF07394.12 KOS23444.1 - 0.28 10.2 0.6 0.49 9.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) Sec61_beta PF03911.16 KOS23445.1 - 1.6e-19 69.6 1.5 2.2e-19 69.2 1.5 1.2 1 0 0 1 1 1 1 Sec61beta family Glyco_transf_28 PF03033.20 KOS23446.1 - 1e-18 67.7 1.0 1.4e-10 41.3 0.1 2.5 2 0 0 2 2 2 2 Glycosyltransferase family 28 N-terminal domain ATG_C PF09333.11 KOS23446.1 - 1e-05 25.7 0.0 4e-05 23.9 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain UDPGT PF00201.18 KOS23446.1 - 0.00096 18.1 0.5 0.0017 17.3 0.0 1.5 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glyco_tran_28_C PF04101.16 KOS23446.1 - 0.089 12.8 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Rpn9_C PF18261.1 KOS23447.1 - 3.3e-08 33.0 0.9 8.2e-08 31.7 0.9 1.7 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 KOS23447.1 - 2e-07 31.5 0.1 6.8e-07 29.8 0.0 1.9 2 0 0 2 2 2 1 PCI domain ANAPC5 PF12862.7 KOS23447.1 - 0.014 15.4 6.0 0.28 11.3 0.5 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 VP9 PF09625.10 KOS23447.1 - 0.018 15.2 0.0 0.053 13.7 0.0 1.7 1 0 0 1 1 1 0 VP9 protein NmrA PF05368.13 KOS23448.1 - 0.11 12.0 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family Lactamase_B PF00753.27 KOS23449.1 - 7.5e-15 55.5 3.0 2.3e-13 50.6 3.0 2.0 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 KOS23449.1 - 9.9e-06 25.2 0.2 1.6e-05 24.5 0.2 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 KOS23449.1 - 0.01 15.8 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Rsa3 PF14615.6 KOS23450.1 - 3.3e-19 68.2 0.4 4.3e-19 67.8 0.4 1.2 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Glu-tRNAGln PF02686.15 KOS23450.1 - 0.025 14.9 0.5 0.032 14.5 0.5 1.1 1 0 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit UAF_Rrn10 PF05234.11 KOS23450.1 - 0.06 13.6 0.0 0.071 13.4 0.0 1.1 1 0 0 1 1 1 0 UAF complex subunit Rrn10 NAD_synthase PF02540.17 KOS23451.1 - 0.1 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 NAD synthase UCH PF00443.29 KOS23452.1 - 2.8e-07 30.3 0.1 3.1e-07 30.2 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase HATPase_c PF02518.26 KOS23453.1 - 2.7e-26 92.3 1.2 4.5e-26 91.5 0.4 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 KOS23453.1 - 1.4e-20 73.5 0.6 9.8e-20 70.8 0.1 2.4 2 0 0 2 2 2 1 Response regulator receiver domain HisKA PF00512.25 KOS23453.1 - 1.8e-19 69.5 0.1 4.4e-19 68.3 0.1 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 KOS23453.1 - 7.6e-08 32.5 0.1 0.0024 18.1 0.0 2.9 3 0 0 3 3 3 2 PAS fold PAS_9 PF13426.7 KOS23453.1 - 0.00079 19.6 0.0 0.084 13.1 0.0 2.9 2 0 0 2 2 2 1 PAS domain PAS PF00989.25 KOS23453.1 - 0.0025 17.8 0.0 0.0083 16.1 0.0 1.8 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 KOS23453.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 PAS domain Allantoicase PF03561.15 KOS23454.1 - 1.3e-96 320.3 0.0 4.2e-47 159.7 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat DIL PF01843.19 KOS23455.1 - 9e-30 103.0 0.3 1.9e-29 102.0 0.3 1.6 1 0 0 1 1 1 1 DIL domain Ank_2 PF12796.7 KOS23455.1 - 4.4e-15 56.0 0.0 2.6e-14 53.6 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 KOS23455.1 - 2.7e-10 40.2 0.0 0.00049 20.4 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 KOS23455.1 - 6.1e-10 39.4 0.0 7.8e-05 23.2 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 KOS23455.1 - 1.8e-09 37.7 0.0 9.1e-06 25.9 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 KOS23455.1 - 5.9e-08 32.4 0.0 0.1 13.2 0.0 4.2 3 0 0 3 3 3 2 Ankyrin repeat Cytochrom_B561 PF03188.16 KOS23456.1 - 1.5e-15 57.6 3.8 2.7e-15 56.7 3.8 1.4 1 0 0 1 1 1 1 Eukaryotic cytochrome b561 DUF4079 PF13301.6 KOS23456.1 - 0.0043 17.2 17.0 0.17 12.0 6.9 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF4079) Ferric_reduct PF01794.19 KOS23456.1 - 0.021 14.9 4.9 0.2 11.8 1.5 2.8 2 1 0 2 2 2 0 Ferric reductase like transmembrane component DUF420 PF04238.12 KOS23456.1 - 0.18 12.1 8.0 0.49 10.7 8.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF420) DUF5134 PF17197.4 KOS23456.1 - 1.9 8.4 16.2 3.6 7.5 16.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5134) DUF1168 PF06658.12 KOS23457.1 - 1.6e-32 112.1 15.5 1.6e-32 112.1 15.5 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1168) GRP PF07172.11 KOS23457.1 - 3.1 8.5 14.5 5.6 7.7 14.5 1.5 1 0 0 1 1 1 0 Glycine rich protein family His_Phos_1 PF00300.22 KOS23458.1 - 1.9e-29 102.8 0.2 8.1e-29 100.7 0.0 2.0 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 KOS23458.1 - 0.02 14.3 0.0 0.045 13.1 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) HET PF06985.11 KOS23459.1 - 1.2e-17 64.6 0.0 2.2e-17 63.8 0.0 1.4 1 0 0 1 1 1 1 Heterokaryon incompatibility protein (HET) Cpn60_TCP1 PF00118.24 KOS23460.1 - 3.2e-173 576.9 1.1 3.6e-173 576.7 1.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family BRK PF07533.16 KOS23460.1 - 0.057 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 BRK domain Pyr_redox_2 PF07992.14 KOS23461.1 - 2.5e-58 197.7 0.5 3.4e-58 197.2 0.5 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 KOS23461.1 - 2.4e-32 111.4 0.0 2.6e-31 108.1 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 KOS23461.1 - 3.7e-18 65.9 1.3 1.5e-16 60.7 0.0 2.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 KOS23461.1 - 3e-09 36.6 0.0 1.7e-08 34.1 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 KOS23461.1 - 0.0018 17.5 0.0 0.0028 16.8 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 KOS23461.1 - 0.01 15.1 0.3 0.019 14.2 0.3 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 KOS23461.1 - 0.011 14.9 0.3 0.052 12.6 0.2 2.1 3 0 0 3 3 3 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 KOS23461.1 - 0.045 13.1 0.2 0.08 12.3 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 KOS23461.1 - 0.051 12.9 1.6 8.2 5.7 0.9 2.3 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 KOS23461.1 - 0.075 12.1 4.6 2.6 7.0 1.9 2.7 3 0 0 3 3 3 0 FAD binding domain HI0933_like PF03486.14 KOS23461.1 - 0.2 10.3 0.5 9.2 4.8 1.2 2.7 3 0 0 3 3 3 0 HI0933-like protein 3HCDH_N PF02737.18 KOS23461.1 - 0.22 11.4 0.9 0.72 9.7 0.0 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 KOS23461.1 - 0.49 9.7 2.8 0.96 8.8 0.0 2.5 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_8 PF13450.6 KOS23461.1 - 4.5 7.6 6.0 0.71 10.2 1.5 2.1 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Ecl1 PF12855.7 KOS23462.1 - 1.2e-16 62.3 19.9 1.5e-16 62.1 19.9 1.0 1 0 0 1 1 1 1 ECL1/2/3 zinc binding proteins DUF2116 PF09889.9 KOS23462.1 - 0.066 13.2 0.3 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) PLATZ PF04640.14 KOS23462.1 - 0.098 13.3 0.9 0.098 13.3 0.9 1.9 2 0 0 2 2 2 0 PLATZ transcription factor DENN PF02141.21 KOS23463.1 - 2.8e-41 141.5 0.0 4.5e-41 140.9 0.0 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Elongin_A PF06881.11 KOS23463.1 - 0.016 15.7 3.8 0.016 15.7 3.8 2.3 3 0 0 3 3 3 0 RNA polymerase II transcription factor SIII (Elongin) subunit A KASH_CCD PF14662.6 KOS23463.1 - 0.79 9.5 17.9 4.2 7.2 17.9 1.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH PCRF PF03462.18 KOS23463.1 - 3.7 7.4 12.9 0.49 10.2 5.9 2.5 2 1 1 3 3 3 0 PCRF domain Cnn_1N PF07989.11 KOS23463.1 - 6.5 7.0 13.7 2.3 8.4 3.5 3.1 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DUF2570 PF10828.8 KOS23463.1 - 6.7 6.6 9.0 6.6 6.6 6.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) GAS PF13851.6 KOS23463.1 - 8.7 5.6 22.0 8.7 5.6 13.3 3.1 1 1 3 4 4 4 0 Growth-arrest specific micro-tubule binding # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Escovopsis_weberi-ASM127849v1/GCA_001278495.1_ASM127849v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Escovopsis_weberi-ASM127849v1/GCA_001278495.1_ASM127849v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Escovopsis_weberi-ASM127849v1/GCA_001278495.1_ASM127849v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Escovopsis_weberi-ASM127849v1/GCA_001278495.1_ASM127849v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 19:36:34 2019 # [ok]