# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- COX2 PF00116.20 AAS50168.1 - 1.7e-58 195.7 0.1 2.5e-58 195.2 0.1 1.3 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain COX2_TM PF02790.15 AAS50168.1 - 1.9e-32 111.3 4.7 3.5e-32 110.4 4.7 1.5 1 0 0 1 1 1 1 Cytochrome C oxidase subunit II, transmembrane domain COX1 PF00115.20 AAS50169.1 - 5.4e-141 470.4 60.5 6.6e-141 470.1 60.5 1.1 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF3789 PF12664.7 AAS50169.1 - 0.37 10.5 5.0 1.8 8.4 5.0 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) COX3 PF00510.18 AAS50170.1 - 2.1e-113 378.5 28.2 2.3e-113 378.3 28.2 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit III DUF1673 PF07895.11 AAS50170.1 - 4.9 6.8 10.9 0.33 10.6 2.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) VAR1 PF05316.12 AAS50171.1 - 5.4e-117 390.6 133.1 7.4e-117 390.2 133.1 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein (VAR1) Fun_ATP-synt_8 PF05933.13 AAS50172.1 - 2.3e-19 69.3 13.0 2.5e-19 69.2 13.0 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) ATP-synt_A PF00119.20 AAS50173.1 - 1.5e-41 142.6 37.0 1.9e-41 142.4 37.0 1.1 1 0 0 1 1 1 1 ATP synthase A chain ATP-synt_C PF00137.21 AAS50174.1 - 2e-12 47.3 11.2 2.5e-12 47.0 11.2 1.1 1 0 0 1 1 1 1 ATP synthase subunit C DUF3493 PF11998.8 AAS50174.1 - 0.15 12.2 2.0 0.25 11.6 1.9 1.6 1 1 0 1 1 1 0 Low psii accumulation1 / Rep27 Cytochrome_B PF00033.19 AAS50175.1 - 1.3e-76 256.7 22.7 1.3e-76 256.7 22.7 2.5 2 1 0 2 2 2 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 AAS50175.1 - 3.5e-38 131.3 16.3 3.5e-38 131.3 16.3 2.7 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 AAS50175.1 - 3.5e-33 114.0 1.0 3.5e-33 114.0 1.0 3.3 3 1 0 3 3 3 1 Cytochrome b(C-terminal)/b6/petD CPBP PF02517.16 AAS50180.1 - 7.3e-17 61.5 3.4 7.3e-17 61.5 3.4 1.9 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Zds_C PF08632.10 AAS50181.1 - 5.2e-30 102.9 3.3 1.1e-29 101.9 2.6 1.9 2 0 0 2 2 2 1 Activator of mitotic machinery Cdc14 phosphatase activation C-term DUF1892 PF08987.10 AAS50182.1 - 3.6e-49 165.5 1.6 4.1e-49 165.3 1.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1892) Cyt-b5 PF00173.28 AAS50183.1 - 1.4e-18 66.8 3.0 2.9e-18 65.8 0.2 2.3 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain FA_hydroxylase PF04116.13 AAS50183.1 - 2.3e-13 50.6 14.1 2.3e-13 50.6 14.1 1.9 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Anth_synt_I_N PF04715.13 AAS50183.1 - 0.037 14.2 0.1 0.1 12.8 0.1 1.7 2 0 0 2 2 2 0 Anthranilate synthase component I, N terminal region TMEM189_B_dmain PF10520.9 AAS50183.1 - 9.1 6.4 10.6 6.1 6.9 1.9 2.8 1 1 1 2 2 2 0 B domain of TMEM189, localisation domain SMC_N PF02463.19 AAS50184.1 - 3.1e-61 206.6 16.0 5e-61 205.9 16.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AAS50184.1 - 3.4e-28 98.3 1.1 1e-27 96.7 0.0 2.5 3 0 0 3 3 3 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AAS50184.1 - 1.2e-13 51.6 10.8 6.2e-08 32.8 4.4 3.7 2 2 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AAS50184.1 - 1e-08 35.3 25.3 1e-08 35.3 25.3 5.1 2 2 2 4 4 4 1 AAA ATPase domain AAA_23 PF13476.6 AAS50184.1 - 0.0055 17.2 51.2 0.0055 17.2 51.2 8.4 2 2 3 5 5 5 1 AAA domain BLOC1_2 PF10046.9 AAS50184.1 - 0.0072 16.6 8.4 0.0072 16.6 8.4 9.6 4 2 5 10 10 10 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 BRCT PF00533.26 AAS50184.1 - 0.03 14.7 0.8 74 3.8 0.0 5.1 5 0 0 5 5 5 0 BRCA1 C Terminus (BRCT) domain AAA_29 PF13555.6 AAS50184.1 - 0.12 12.2 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cytokin_check_N PF10407.9 AAS50185.1 - 8.9e-33 112.1 0.4 6.4e-32 109.3 0.2 2.2 2 0 0 2 2 2 1 Cdc14 phosphatase binding protein N-terminus DUF3915 PF13054.6 AAS50185.1 - 3.1 7.8 5.5 10 6.1 5.5 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) CAP PF00188.26 AAS50187.1 - 2.6e-19 70.3 1.0 6.5e-19 69.0 0.1 2.0 2 0 0 2 2 2 1 Cysteine-rich secretory protein family CPDase PF07823.11 AAS50187.1 - 0.12 12.0 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Cyclic phosphodiesterase-like protein eIF_4G1 PF12152.8 AAS50187.1 - 8.1 6.7 9.4 1.9 8.7 4.5 2.4 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 4G1 CAP PF00188.26 AAS50188.1 - 1.4e-21 77.7 0.6 2.3e-21 76.9 0.6 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Bystin PF05291.11 AAS50188.1 - 0.02 14.2 0.0 0.027 13.8 0.0 1.1 1 0 0 1 1 1 0 Bystin KH_1 PF00013.29 AAS50189.1 - 1e-88 291.1 31.0 3.3e-13 49.2 0.0 11.5 12 0 0 12 12 12 8 KH domain KH_2 PF07650.17 AAS50189.1 - 6.2e-13 48.4 16.5 0.00028 20.6 0.4 7.0 6 0 0 6 6 6 5 KH domain KH_4 PF13083.6 AAS50189.1 - 2.9e-06 27.0 1.0 0.26 11.2 0.0 5.8 6 0 0 6 6 6 1 KH domain MOEP19 PF16005.5 AAS50189.1 - 5.8e-06 26.2 0.2 6.1 6.9 0.0 5.5 6 1 0 6 6 6 1 KH-like RNA-binding domain KH_5 PF13184.6 AAS50189.1 - 7.6e-06 25.9 16.9 0.79 9.9 0.0 6.5 7 0 0 7 7 7 3 NusA-like KH domain SLS PF14611.6 AAS50189.1 - 5.3e-05 23.2 10.1 0.24 11.2 0.1 6.7 5 3 2 7 7 7 2 Mitochondrial inner-membrane-bound regulator BMC PF00936.19 AAS50189.1 - 0.0024 17.8 2.8 1.7 8.7 0.0 5.1 6 0 0 6 6 6 1 BMC domain Alba PF01918.21 AAS50189.1 - 0.049 13.5 1.0 13 5.7 0.1 4.0 3 0 0 3 3 3 0 Alba BRE1 PF08647.11 AAS50189.1 - 0.082 13.0 3.2 0.31 11.1 1.2 2.9 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase TPK_B1_binding PF04265.14 AAS50189.1 - 0.083 12.6 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain Ras PF00071.22 AAS50190.1 - 3e-53 179.7 0.1 3.5e-53 179.5 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS50190.1 - 1.5e-36 125.3 0.0 2e-36 124.8 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS50190.1 - 3.3e-14 52.7 0.0 4.5e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS50190.1 - 2.4e-07 30.3 0.0 3.3e-07 29.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS50190.1 - 9.9e-06 25.6 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS50190.1 - 0.00043 20.2 0.1 0.91 9.4 0.1 2.4 1 1 2 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 AAS50190.1 - 0.00047 19.8 0.0 0.00087 18.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AAS50190.1 - 0.012 16.0 0.0 0.017 15.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 AAS50190.1 - 0.027 13.9 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Fungal_trans_2 PF11951.8 AAS50191.1 - 3.2e-112 375.2 4.6 4e-112 374.8 4.6 1.1 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS50191.1 - 4.3e-13 49.2 5.5 1.1e-12 47.9 5.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dynamin_M PF01031.20 AAS50192.1 - 2.9e-109 364.7 0.0 4.9e-109 364.0 0.0 1.4 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 AAS50192.1 - 5.3e-55 186.0 0.6 2e-54 184.2 0.0 2.3 3 1 0 3 3 3 1 Dynamin family GED PF02212.18 AAS50192.1 - 6.4e-30 103.1 0.9 1.8e-29 101.7 0.9 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AAS50192.1 - 7.3e-05 22.8 0.0 0.00061 19.9 0.0 2.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS50192.1 - 0.013 15.9 0.1 0.23 11.8 0.0 2.8 4 0 0 4 4 4 0 AAA ATPase domain AAA_15 PF13175.6 AAS50192.1 - 0.52 10.0 0.0 0.52 10.0 0.0 2.9 3 0 0 3 3 3 0 AAA ATPase domain HAT_KAT11 PF08214.11 AAS50193.1 - 1.5e-96 323.8 0.0 1.7e-96 323.6 0.0 1.0 1 0 0 1 1 1 1 Histone acetylation protein DUF1610 PF07754.11 AAS50193.1 - 0.21 11.6 1.1 0.49 10.4 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) Proteasome PF00227.26 AAS50194.1 - 2.2e-48 164.3 0.4 2.5e-48 164.1 0.4 1.0 1 0 0 1 1 1 1 Proteasome subunit Sfi1_C PF10638.9 AAS50195.1 - 1e-37 129.0 3.7 1e-37 129.0 3.7 3.0 3 0 0 3 3 3 1 Spindle body associated protein C-terminus Sfi1 PF08457.10 AAS50195.1 - 8.8e-22 77.4 69.1 3.9e-19 68.6 49.3 2.7 1 1 0 2 2 2 2 Sfi1 spindle body protein EF1G PF00647.19 AAS50195.1 - 3 7.9 14.2 1.4 9.0 0.4 4.3 4 1 1 5 5 5 0 Elongation factor 1 gamma, conserved domain Ribophorin_I PF04597.14 AAS50196.1 - 2.6e-116 389.5 0.4 2.9e-116 389.3 0.4 1.0 1 0 0 1 1 1 1 Ribophorin I 2_5_RNA_ligase2 PF13563.6 AAS50196.1 - 0.11 12.4 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 2'-5' RNA ligase superfamily ORC_WH_C PF18137.1 AAS50197.1 - 1e-24 87.2 0.0 2e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal ORC3_N PF07034.11 AAS50197.1 - 9.1e-07 28.3 3.2 1.3e-05 24.5 2.1 2.8 3 1 0 3 3 3 1 Origin recognition complex (ORC) subunit 3 N-terminus COX16 PF14138.6 AAS50198.1 - 3.2e-28 98.0 0.0 4.8e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein COX16 RSN1_7TM PF02714.15 AAS50199.1 - 1.4e-78 264.0 25.4 1.4e-78 264.0 25.4 3.3 4 0 0 4 4 4 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AAS50199.1 - 6.4e-29 100.7 2.9 6.4e-29 100.7 2.9 2.9 4 0 0 4 4 4 1 Late exocytosis, associated with Golgi transport PHM7_ext PF12621.8 AAS50199.1 - 0.00015 21.8 0.0 0.00037 20.6 0.0 1.6 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter PHM7_cyt PF14703.6 AAS50199.1 - 0.0019 18.5 0.0 0.0065 16.7 0.0 1.9 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3839 PF12943.7 AAS50199.1 - 0.082 12.3 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3839) MMM1 PF10296.9 AAS50200.1 - 5.6e-141 469.4 0.0 7.2e-141 469.0 0.0 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 CRR7 PF12095.8 AAS50200.1 - 0.065 13.7 0.3 16 6.0 0.0 2.8 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 PH_12 PF16457.5 AAS50201.1 - 2.9e-11 44.0 0.0 9.1e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain BSD PF03909.17 AAS50201.1 - 0.062 13.3 0.1 0.22 11.6 0.1 2.0 1 0 0 1 1 1 0 BSD domain DEAD PF00270.29 AAS50202.1 - 2.8e-46 157.5 0.0 5.9e-46 156.4 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS50202.1 - 1.1e-28 99.7 0.1 1e-27 96.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CGI-121 PF08617.10 AAS50202.1 - 0.045 13.9 1.3 0.13 12.4 0.1 2.1 2 0 0 2 2 2 0 Kinase binding protein CGI-121 AAA_22 PF13401.6 AAS50202.1 - 0.79 10.0 5.5 0.14 12.4 0.4 2.5 3 1 0 3 3 3 0 AAA domain SYS1 PF09801.9 AAS50203.1 - 1.6e-52 177.5 14.7 1.8e-52 177.3 14.7 1.0 1 0 0 1 1 1 1 Integral membrane protein S linking to the trans Golgi network LRR_8 PF13855.6 AAS50204.1 - 1.7e-48 162.2 74.0 2.8e-11 43.0 5.8 9.7 8 2 2 10 10 10 8 Leucine rich repeat PP2C PF00481.21 AAS50204.1 - 3.6e-42 144.8 0.2 6e-42 144.0 0.2 1.4 1 0 0 1 1 1 1 Protein phosphatase 2C LRR_4 PF12799.7 AAS50204.1 - 2.8e-31 107.0 84.7 3.9e-06 27.1 2.2 12.6 5 2 8 14 14 14 11 Leucine Rich repeats (2 copies) Guanylate_cyc PF00211.20 AAS50204.1 - 3.2e-26 92.1 0.0 7.2e-26 90.9 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain LRR_9 PF14580.6 AAS50204.1 - 3.6e-06 26.6 31.2 0.00071 19.1 6.4 4.9 2 1 2 4 4 4 3 Leucine-rich repeat LRR_1 PF00560.33 AAS50204.1 - 0.0037 17.6 54.2 3.1 8.7 0.1 15.6 14 2 0 14 14 14 1 Leucine Rich Repeat LRR_5 PF13306.6 AAS50204.1 - 0.0039 17.2 7.5 0.16 11.9 1.5 4.0 3 1 0 3 3 3 2 BspA type Leucine rich repeat region (6 copies) Ad_cyc_g-alpha PF08509.11 AAS50204.1 - 0.074 12.8 0.1 0.22 11.3 0.1 1.8 1 0 0 1 1 1 0 Adenylate cyclase G-alpha binding domain COX17 PF05051.13 AAS50205.1 - 5e-22 78.0 6.4 5.8e-22 77.8 6.4 1.1 1 0 0 1 1 1 1 Cytochrome C oxidase copper chaperone (COX17) Cmc1 PF08583.10 AAS50205.1 - 0.0012 18.9 3.1 0.014 15.4 0.1 2.1 1 1 1 2 2 2 2 Cytochrome c oxidase biogenesis protein Cmc1 like CHCH PF06747.13 AAS50205.1 - 0.0091 16.1 2.0 0.013 15.6 2.0 1.3 1 0 0 1 1 1 1 CHCH domain PNP_UDP_1 PF01048.20 AAS50206.1 - 4.7e-36 124.2 0.0 5.5e-36 124.0 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily NiFe_hyd_SSU_C PF14720.6 AAS50206.1 - 0.085 13.2 0.0 5.7 7.4 0.0 2.4 2 0 0 2 2 2 0 NiFe/NiFeSe hydrogenase small subunit C-terminal NPCC PF08058.11 AAS50207.1 - 1.6e-32 112.3 0.2 2.2e-32 111.9 0.2 1.2 1 0 0 1 1 1 1 Nuclear pore complex component NIF PF03031.18 AAS50208.1 - 4.8e-52 175.9 0.1 6.7e-52 175.4 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Sof1 PF04158.14 AAS50209.1 - 7.3e-30 103.1 13.2 1.1e-28 99.3 15.0 2.0 2 0 0 2 2 2 1 Sof1-like domain WD40 PF00400.32 AAS50209.1 - 1.1e-24 86.2 6.5 1.8e-06 28.6 0.0 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50209.1 - 3.9e-07 30.3 0.3 0.088 13.1 0.0 4.9 2 2 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS50209.1 - 0.00059 18.9 0.3 0.043 12.8 0.1 3.0 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AAS50209.1 - 0.0011 18.9 0.9 0.15 11.9 0.2 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AAS50209.1 - 0.0017 17.8 0.0 0.036 13.4 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 AAS50209.1 - 0.0026 17.8 0.1 3.6 7.7 0.0 3.4 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Abhydro_lipase PF04083.16 AAS50210.1 - 2e-14 52.9 0.0 3.5e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 AAS50210.1 - 5.7e-09 36.0 0.0 9.3e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AAS50210.1 - 0.00024 20.4 0.0 0.00056 19.2 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF3387 PF11867.8 AAS50210.1 - 0.02 14.3 0.2 0.032 13.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3387) DUF900 PF05990.12 AAS50210.1 - 0.024 14.1 0.0 0.037 13.5 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Lipase_2 PF01674.18 AAS50210.1 - 0.15 11.6 0.0 0.37 10.3 0.0 1.7 1 1 0 1 1 1 0 Lipase (class 2) POC3_POC4 PF10448.9 AAS50211.1 - 1.8e-46 157.7 0.0 2e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 SBDS PF01172.18 AAS50212.1 - 7.2e-34 115.7 1.5 1.1e-33 115.1 1.5 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 AAS50212.1 - 8.4e-31 106.4 0.2 1.5e-30 105.6 0.2 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain HlyIII PF03006.20 AAS50213.1 - 3.9e-55 187.0 15.6 3.9e-55 187.0 15.6 1.4 2 0 0 2 2 2 1 Haemolysin-III related PUF PF00806.19 AAS50214.1 - 2.7e-52 171.6 11.4 6.9e-08 31.8 0.1 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2483 PF10656.9 AAS50214.1 - 0.13 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Hypothetical protein of unknown function (DUF2483) GHMP_kinases_N PF00288.26 AAS50214.1 - 0.36 11.1 3.6 0.77 10.0 0.2 3.0 3 0 0 3 3 3 0 GHMP kinases N terminal domain Rab5ip PF07019.12 AAS50215.1 - 3.3e-24 85.3 2.3 3.8e-24 85.1 2.3 1.1 1 0 0 1 1 1 1 Rab5-interacting protein (Rab5ip) DUF383 PF04063.14 AAS50216.1 - 4.4e-62 209.2 0.3 4e-61 206.0 0.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF383) DUF384 PF04064.13 AAS50216.1 - 1.3e-24 85.8 0.4 3.8e-24 84.3 0.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF384) TFIIF_alpha PF05793.12 AAS50217.1 - 6.8e-13 48.1 35.8 2.9e-09 36.1 0.4 2.8 2 1 1 3 3 3 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PDZ_2 PF13180.6 AAS50217.1 - 0.074 13.4 0.0 0.4 11.0 0.0 2.2 1 0 0 1 1 1 0 PDZ domain tRNA-synt_1b PF00579.25 AAS50218.1 - 1.8e-73 247.4 0.0 2.3e-73 247.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) HD_2 PF12917.7 AAS50218.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme zf-UBR PF02207.20 AAS50219.2 - 4.6e-12 45.9 9.9 4.6e-12 45.9 9.9 2.7 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) Hemolysin_N PF12563.8 AAS50219.2 - 0.11 12.0 0.0 0.24 11.0 0.0 1.4 1 0 0 1 1 1 0 Hemolytic toxin N terminal zf-B_box PF00643.24 AAS50219.2 - 0.14 12.3 8.7 0.67 10.2 8.7 2.3 1 0 0 1 1 1 0 B-box zinc finger ZZ PF00569.17 AAS50219.2 - 0.38 10.6 8.5 1.5 8.7 8.5 2.1 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-UBR PF02207.20 AAS50220.1 - 1.7e-16 60.2 12.3 1.7e-16 60.2 12.3 2.3 3 0 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ClpS PF02617.17 AAS50220.1 - 7.8e-05 22.4 0.0 0.00022 20.9 0.0 1.8 1 0 0 1 1 1 1 ATP-dependent Clp protease adaptor protein ClpS zf-RING_2 PF13639.6 AAS50220.1 - 9.8e-05 22.6 1.0 9.8e-05 22.6 1.0 3.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 AAS50220.1 - 0.0039 17.0 1.1 0.021 14.7 1.1 2.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AAS50220.1 - 0.0077 16.5 0.3 0.0077 16.5 0.3 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 AAS50220.1 - 0.01 15.6 0.8 0.045 13.6 0.8 2.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS50220.1 - 0.015 15.2 1.0 0.015 15.2 1.0 2.6 2 0 0 2 2 2 0 zinc-RING finger domain DUF4447 PF14590.6 AAS50220.1 - 0.14 11.9 0.0 0.43 10.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4447) DUF2175 PF09943.9 AAS50220.1 - 0.22 11.8 1.5 1.3 9.3 0.3 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) UCR_UQCRX_QCR9 PF05365.12 AAS50221.1 - 5.6e-28 96.6 1.5 6.2e-28 96.5 1.5 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like zf-Tim10_DDP PF02953.15 AAS50222.1 - 6.6e-19 67.3 1.7 9.5e-19 66.8 1.7 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger NES_C_h PF18208.1 AAS50222.1 - 0.12 12.7 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain Clat_adaptor_s PF01217.20 AAS50223.1 - 4.6e-57 191.9 1.8 5.4e-57 191.7 1.8 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain CBP4 PF07960.11 AAS50224.2 - 3.8e-55 185.3 4.9 4.4e-55 185.0 4.9 1.0 1 0 0 1 1 1 1 CBP4 DUF4574 PF15141.6 AAS50224.2 - 0.00023 21.0 3.1 0.0019 18.1 0.0 2.2 2 0 0 2 2 2 1 Ubiquinol-cytochrome-c reductase complex assembly factor 3 FapA PF03961.13 AAS50224.2 - 0.014 14.1 0.6 0.017 13.8 0.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AIP3 PF03915.13 AAS50224.2 - 0.024 13.7 5.5 0.029 13.5 5.5 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 DUF4407 PF14362.6 AAS50224.2 - 0.031 13.6 2.3 0.038 13.4 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LAMTOR PF15454.6 AAS50224.2 - 0.047 14.3 8.7 0.096 13.3 0.8 2.2 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF5427 PF10310.9 AAS50224.2 - 0.41 9.6 11.7 0.5 9.3 11.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Jnk-SapK_ap_N PF09744.9 AAS50224.2 - 1.1 9.5 14.9 0.14 12.4 1.1 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 60KD_IMP PF02096.20 AAS50224.2 - 1.2 9.0 4.3 8.3 6.3 0.1 2.1 2 0 0 2 2 2 0 60Kd inner membrane protein Pet100 PF09803.9 AAS50224.2 - 1.2 9.7 3.7 2.9 8.5 1.7 2.1 2 0 0 2 2 2 0 Pet100 SE PF08491.10 AAS50225.1 - 7.4e-121 402.4 0.0 9.2e-121 402.1 0.0 1.1 1 0 0 1 1 1 1 Squalene epoxidase FAD_binding_3 PF01494.19 AAS50225.1 - 4.2e-14 52.5 0.0 1.5e-13 50.8 0.0 1.7 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 AAS50225.1 - 4.9e-06 26.4 0.0 5.8e-05 22.8 0.1 2.0 2 0 0 2 2 2 1 FAD dependent oxidoreductase Shikimate_DH PF01488.20 AAS50225.1 - 0.00012 22.2 0.0 0.0002 21.4 0.0 1.3 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase FAD_binding_2 PF00890.24 AAS50225.1 - 0.00045 19.4 0.4 0.00082 18.6 0.2 1.5 2 0 0 2 2 2 1 FAD binding domain NAD_binding_8 PF13450.6 AAS50225.1 - 0.0006 20.0 0.1 0.0014 18.8 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AAS50225.1 - 0.0012 19.3 0.2 0.003 18.1 0.1 1.7 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AAS50225.1 - 0.0044 16.4 0.7 0.0079 15.6 0.6 1.4 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 AAS50225.1 - 0.0081 15.4 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Pyr_redox_2 PF07992.14 AAS50225.1 - 0.0088 15.3 0.1 0.018 14.3 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AAS50225.1 - 0.0094 15.8 0.1 0.014 15.3 0.1 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 AAS50225.1 - 0.1 12.2 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 AAS50225.1 - 0.11 11.6 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 Glucose inhibited division protein A Sacchrp_dh_NADP PF03435.18 AAS50225.1 - 0.11 12.7 0.1 0.21 11.8 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain HI0933_like PF03486.14 AAS50225.1 - 0.11 11.1 0.2 0.3 9.7 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 AAS50225.1 - 0.15 11.6 0.1 0.42 10.1 0.1 1.7 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GDI PF00996.18 AAS50225.1 - 0.2 10.2 0.0 0.3 9.6 0.0 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor zf-RRN7 PF11781.8 AAS50226.1 - 1.7e-08 34.0 1.5 2.6e-08 33.4 1.5 1.3 1 0 0 1 1 1 1 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 MarR_2 PF12802.7 AAS50226.1 - 0.036 13.9 0.4 0.036 13.9 0.4 2.2 3 0 0 3 3 3 0 MarR family GntR PF00392.21 AAS50226.1 - 0.037 13.7 0.2 0.076 12.7 0.2 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family AA_permease_N PF08403.10 AAS50226.1 - 0.051 13.1 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal ssDNA-exonuc_C PF10141.9 AAS50226.1 - 0.11 12.1 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain LsmAD PF06741.13 AAS50227.1 - 5e-29 100.6 0.4 1.6e-28 99.0 0.4 1.9 1 0 0 1 1 1 1 LsmAD domain SM-ATX PF14438.6 AAS50227.1 - 8.5e-13 48.3 0.2 3.9e-12 46.1 0.0 2.3 2 0 0 2 2 2 1 Ataxin 2 SM domain CENP-Q PF13094.6 AAS50228.1 - 0.0003 21.0 1.7 0.00058 20.1 1.7 1.6 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Arfaptin PF06456.13 AAS50228.1 - 0.056 13.0 0.2 0.15 11.6 0.1 1.7 2 0 0 2 2 2 0 Arfaptin-like domain PXA PF02194.15 AAS50228.1 - 0.25 11.3 1.7 0.45 10.5 1.7 1.4 1 0 0 1 1 1 0 PXA domain DUF2267 PF10025.9 AAS50228.1 - 2.4 8.4 9.0 18 5.6 8.0 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) Thi4 PF01946.17 AAS50229.1 - 1.8e-105 351.4 0.2 2.2e-105 351.1 0.2 1.1 1 0 0 1 1 1 1 Thi4 family DAO PF01266.24 AAS50229.1 - 2.5e-07 30.6 2.4 4.9e-07 29.7 0.9 1.9 1 1 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AAS50229.1 - 1.1e-06 28.8 0.9 7e-06 26.2 0.1 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AAS50229.1 - 9.8e-06 25.6 1.6 0.00015 21.8 0.1 2.5 3 0 0 3 3 3 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 AAS50229.1 - 4.4e-05 22.8 2.6 0.00093 18.4 0.9 2.1 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_2 PF07992.14 AAS50229.1 - 0.00034 19.9 0.1 0.00077 18.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AAS50229.1 - 0.00036 19.7 0.4 0.00059 19.0 0.4 1.3 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_oxidored PF12831.7 AAS50229.1 - 0.0012 18.3 0.1 0.002 17.6 0.1 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AAS50229.1 - 0.0059 15.4 0.5 0.011 14.5 0.5 1.4 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 AAS50229.1 - 0.01 15.1 0.0 0.02 14.2 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AAS50229.1 - 0.02 14.2 0.1 0.035 13.3 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 AAS50229.1 - 0.029 13.4 0.2 0.12 11.4 0.1 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 AAS50229.1 - 0.03 13.2 0.3 0.045 12.6 0.3 1.2 1 0 0 1 1 1 0 Tryptophan halogenase K_oxygenase PF13434.6 AAS50229.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Ribonuc_red_sm PF00268.21 AAS50230.1 - 2.6e-120 401.1 4.4 3.3e-120 400.8 4.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain RE_XcyI PF09571.10 AAS50230.1 - 0.1 11.8 0.2 5.1 6.3 0.1 2.2 2 0 0 2 2 2 0 XcyI restriction endonuclease DUF4744 PF15918.5 AAS50230.1 - 0.13 13.1 0.0 0.36 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4744) Yip1 PF04893.17 AAS50231.1 - 4.7e-06 26.4 18.7 1.1e-05 25.2 18.7 1.6 1 1 0 1 1 1 1 Yip1 domain MMR_HSR1_Xtn PF16897.5 AAS50232.1 - 1e-35 121.9 0.5 1.9e-35 121.1 0.5 1.4 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain MMR_HSR1 PF01926.23 AAS50232.1 - 5.5e-22 78.0 0.1 1.3e-21 76.8 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AAS50232.1 - 1e-20 73.5 0.0 2.2e-20 72.4 0.0 1.6 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AAS50232.1 - 1.7e-13 50.4 0.0 2.7e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AAS50232.1 - 0.0001 22.4 0.4 0.017 15.2 0.0 2.4 1 1 1 2 2 2 1 Dynamin family AIG1 PF04548.16 AAS50232.1 - 0.0046 16.3 0.1 0.0079 15.5 0.1 1.4 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 AAS50232.1 - 0.0059 16.1 0.4 0.019 14.4 0.1 1.9 1 1 1 2 2 2 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AAS50232.1 - 0.015 15.5 0.6 0.21 11.8 0.0 2.6 2 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AAS50232.1 - 0.035 13.7 0.4 1.1 8.8 0.1 2.3 2 0 0 2 2 2 0 Ras family MCM PF00493.23 AAS50232.1 - 0.037 13.1 0.5 0.073 12.2 0.0 1.7 2 0 0 2 2 2 0 MCM P-loop domain GTP_EFTU PF00009.27 AAS50232.1 - 0.039 13.5 1.1 2.6 7.5 0.4 3.1 2 1 1 3 3 3 0 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AAS50232.1 - 0.042 14.2 0.3 0.091 13.1 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain YchF-GTPase_C PF06071.13 AAS50232.1 - 0.15 12.3 0.0 0.72 10.1 0.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF933) RsgA_GTPase PF03193.16 AAS50232.1 - 0.25 11.2 1.3 4.1 7.3 0.1 3.0 2 1 0 3 3 3 0 RsgA GTPase tRNA-synt_1g PF09334.11 AAS50233.1 - 3.1e-89 299.5 0.0 4.9e-89 298.8 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AAS50233.1 - 4.2e-19 68.3 0.0 8.1e-09 34.3 0.0 2.9 3 0 0 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 AAS50233.1 - 7.6e-10 38.6 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 AAS50233.1 - 0.0013 18.7 0.0 0.0028 17.6 0.0 1.5 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1f PF01921.18 AAS50233.1 - 0.004 16.1 0.0 0.0065 15.4 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (K) DNA_pol_D_N PF18018.1 AAS50234.1 - 3.4e-40 137.2 0.0 5.5e-40 136.5 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain DNA_pol_E_B PF04042.16 AAS50234.1 - 2e-38 131.9 0.0 4.2e-38 130.8 0.0 1.5 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B PS_Dcarbxylase PF02666.15 AAS50235.1 - 3.4e-56 190.0 0.0 5.3e-56 189.4 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase C2 PF00168.30 AAS50235.1 - 2.8e-20 72.5 0.1 8.6e-14 51.7 0.0 2.9 2 0 0 2 2 2 2 C2 domain BUD22 PF09073.10 AAS50235.1 - 2.3 7.5 12.5 3.7 6.8 12.5 1.3 1 0 0 1 1 1 0 BUD22 Jnk-SapK_ap_N PF09744.9 AAS50236.1 - 0.99 9.6 14.8 1 9.6 14.8 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 RapA_C PF12137.8 AAS50236.1 - 1.9 7.4 9.7 2.3 7.2 9.7 1.1 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal MAJIN PF15077.6 AAS50236.1 - 4.6 7.0 9.2 5 6.8 9.2 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein OmpH PF03938.14 AAS50236.1 - 7.4 6.9 18.4 8.8 6.7 18.4 1.0 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) HSP20 PF00011.21 AAS50238.1 - 1.8e-19 69.8 0.1 2.3e-19 69.4 0.1 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AAS50238.1 - 1.5e-06 27.6 0.0 2.3e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Rv2175c_C PF18367.1 AAS50238.1 - 0.04 14.0 0.2 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Rv2175c C-terminal domain of unknown function Peptidase_M1 PF01433.20 AAS50239.2 - 1.1e-86 290.0 2.1 1.9e-86 289.1 1.4 1.8 2 0 0 2 2 2 1 Peptidase family M1 domain ERAP1_C PF11838.8 AAS50239.2 - 3.6e-82 276.4 1.9 4.8e-80 269.4 1.2 2.4 2 0 0 2 2 2 2 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 AAS50239.2 - 6.5e-55 186.2 2.8 1e-54 185.5 2.3 1.6 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain RNase_H2-Ydr279 PF09468.10 AAS50241.2 - 7.5e-17 62.0 0.0 3.6e-16 59.8 0.0 2.0 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 AAS50241.2 - 1.3e-13 51.0 0.0 2.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain RNase_PH PF01138.21 AAS50242.1 - 1.2e-19 71.1 0.0 1.9e-19 70.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AAS50242.1 - 3.4e-17 62.2 0.1 1.3e-16 60.4 0.1 2.0 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 HAD_2 PF13419.6 AAS50243.1 - 1.5e-17 64.3 0.0 4.7e-17 62.6 0.0 1.7 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AAS50243.1 - 3.3e-11 43.9 0.2 1.4e-08 35.3 0.2 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AAS50243.1 - 0.0016 18.9 0.0 0.0029 18.0 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase RNA_pol_3_Rpc31 PF11705.8 AAS50243.1 - 0.017 15.4 17.2 0.028 14.7 17.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF155 PF02582.14 AAS50244.1 - 2.2e-46 158.1 0.2 3.5e-46 157.5 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 GvpD PF07088.11 AAS50244.1 - 0.072 11.7 0.1 0.12 11.0 0.1 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein GATase_2 PF00310.21 AAS50244.1 - 0.12 11.1 0.0 0.18 10.5 0.0 1.2 1 0 0 1 1 1 0 Glutamine amidotransferases class-II FAD_binding_1 PF00667.20 AAS50245.1 - 9.3e-74 247.7 0.0 1.3e-73 247.2 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AAS50245.1 - 1.8e-32 112.5 1.6 3.6e-32 111.6 1.6 1.5 1 0 0 1 1 1 1 Flavodoxin NAD_binding_1 PF00175.21 AAS50245.1 - 7.2e-21 74.9 0.0 5.3e-20 72.1 0.0 2.3 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain Spore_IV_A PF09547.10 AAS50245.1 - 2.1e-05 23.7 0.1 5.1e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Stage IV sporulation protein A (spore_IV_A) Flavodoxin_5 PF12724.7 AAS50245.1 - 0.082 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain TetR_C_8 PF14278.6 AAS50245.1 - 0.11 12.6 0.7 1.7 8.8 0.1 2.7 3 0 0 3 3 3 0 Transcriptional regulator C-terminal region dsDNA_bind PF01984.20 AAS50245.1 - 0.28 11.4 2.0 1.4 9.2 0.3 2.2 2 0 0 2 2 2 0 Double-stranded DNA-binding domain MAGE PF01454.19 AAS50246.1 - 3.7e-39 134.6 0.0 4.9e-39 134.2 0.0 1.2 1 0 0 1 1 1 1 MAGE family WD40 PF00400.32 AAS50247.1 - 9.4e-08 32.6 0.0 0.027 15.3 0.0 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50247.1 - 8e-06 26.1 0.0 0.045 14.0 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS50247.1 - 0.0097 14.9 0.1 0.037 13.0 0.0 1.9 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein VPS53_C PF16854.5 AAS50247.1 - 0.013 15.4 0.0 0.022 14.7 0.0 1.3 1 0 0 1 1 1 0 Vacuolar protein sorting-associated protein 53 C-terminus TBCA PF02970.16 AAS50248.1 - 7e-25 87.2 3.5 8.2e-25 87.0 3.5 1.0 1 0 0 1 1 1 1 Tubulin binding cofactor A MA-Mit PF09245.10 AAS50248.1 - 0.015 14.8 0.2 0.017 14.6 0.2 1.2 1 0 0 1 1 1 0 Mycoplasma arthritidis-derived mitogen Thump_like PF18096.1 AAS50248.1 - 0.019 14.9 0.4 0.051 13.5 0.4 1.7 1 1 0 1 1 1 0 THUMP domain-like Fzo_mitofusin PF04799.13 AAS50248.1 - 0.14 11.7 0.8 0.19 11.3 0.8 1.3 1 0 0 1 1 1 0 fzo-like conserved region Orthopox_A5L PF06193.11 AAS50248.1 - 0.15 11.5 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like ATP_bind_1 PF03029.17 AAS50249.1 - 2.1e-78 263.5 0.0 2.6e-78 263.1 0.0 1.1 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 AAS50249.1 - 0.009 16.6 0.0 0.38 11.3 0.0 2.6 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AAS50249.1 - 0.015 15.6 0.0 0.059 13.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AAS50249.1 - 0.032 14.3 0.0 0.53 10.4 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS50249.1 - 0.064 13.6 0.0 0.2 12.1 0.0 2.1 2 1 0 2 2 2 0 AAA ATPase domain MeaB PF03308.16 AAS50249.1 - 0.07 12.1 0.0 0.15 11.0 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 AAS50249.1 - 0.087 13.2 0.9 0.3 11.5 0.1 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AAS50249.1 - 0.16 12.4 0.0 0.43 11.0 0.0 1.8 1 0 0 1 1 1 0 RNA helicase MitMem_reg PF13012.6 AAS50250.1 - 4.7e-33 113.9 0.9 7.1e-33 113.4 0.3 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function JAB PF01398.21 AAS50250.1 - 1.5e-31 108.8 0.0 2.8e-31 107.9 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease UbiA PF01040.18 AAS50251.1 - 9.6e-50 169.2 12.5 9.6e-50 169.2 12.5 1.5 1 1 0 1 1 1 1 UbiA prenyltransferase family Hexapep PF00132.24 AAS50252.1 - 5.1e-05 22.8 6.8 0.0028 17.3 3.5 3.3 1 1 3 4 4 4 3 Bacterial transferase hexapeptide (six repeats) NTP_transf_3 PF12804.7 AAS50252.1 - 0.00046 20.6 0.0 0.00086 19.7 0.0 1.6 1 1 0 1 1 1 1 MobA-like NTP transferase domain Fucokinase PF07959.12 AAS50252.1 - 0.0053 15.8 1.0 0.029 13.3 0.2 2.1 2 0 0 2 2 2 1 L-fucokinase NTP_transferase PF00483.23 AAS50252.1 - 0.0078 15.8 0.0 0.012 15.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 AAS50252.1 - 0.017 13.3 2.1 0.054 11.6 1.7 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 AAS50252.1 - 0.26 11.1 11.2 0.98 9.2 0.5 3.0 2 1 1 3 3 3 0 Hexapeptide repeat of succinyl-transferase AAA PF00004.29 AAS50253.1 - 1.2e-42 145.4 0.0 2.3e-42 144.5 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS50253.1 - 5e-10 39.0 0.2 1.1e-09 37.9 0.2 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AAS50253.1 - 2.3e-08 34.6 0.1 1.6e-05 25.4 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AAS50253.1 - 9.7e-07 28.9 0.1 3e-05 24.0 0.1 2.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Prot_ATP_ID_OB PF16450.5 AAS50253.1 - 1.5e-06 28.0 0.3 1.5e-06 28.0 0.3 1.7 2 0 0 2 2 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AAS50253.1 - 4.1e-05 23.8 0.0 0.0001 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AAS50253.1 - 5.7e-05 22.9 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 AAS50253.1 - 0.00013 21.9 0.0 0.00024 21.1 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AAS50253.1 - 0.0016 18.7 0.2 0.026 14.8 0.1 2.4 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 AAS50253.1 - 0.0016 17.7 0.1 0.003 16.8 0.1 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 AAS50253.1 - 0.0022 18.4 0.0 0.0049 17.2 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 AAS50253.1 - 0.0049 16.3 0.1 0.01 15.2 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AAS50253.1 - 0.0071 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.6 AAS50253.1 - 0.0082 16.7 0.0 0.029 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AAS50253.1 - 0.0093 15.8 1.2 0.54 10.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AAS50253.1 - 0.0099 16.0 0.0 0.024 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AAS50253.1 - 0.011 15.5 0.0 0.029 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 AAS50253.1 - 0.013 15.7 0.3 0.032 14.4 0.3 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family AAA_28 PF13521.6 AAS50253.1 - 0.018 15.3 0.1 0.066 13.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AAS50253.1 - 0.026 13.9 2.0 0.037 13.4 0.0 2.2 3 0 0 3 3 3 0 KaiC AAA_7 PF12775.7 AAS50253.1 - 0.028 13.9 0.0 0.065 12.7 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 AAS50253.1 - 0.033 13.6 0.1 0.074 12.5 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein GAS PF13851.6 AAS50253.1 - 0.034 13.5 5.1 0.067 12.5 5.1 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AAA_14 PF13173.6 AAS50253.1 - 0.053 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 AAS50253.1 - 0.069 12.8 0.2 0.29 10.8 0.0 2.0 2 1 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 AAS50253.1 - 0.07 12.7 0.6 0.2 11.2 0.1 2.0 2 0 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 AAS50253.1 - 0.087 12.1 1.3 0.49 9.6 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Parvo_NS1 PF01057.17 AAS50253.1 - 0.088 11.9 0.1 0.17 11.0 0.1 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_3 PF07726.11 AAS50253.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AAS50253.1 - 0.11 12.9 4.3 12 6.3 3.0 2.5 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AAS50253.1 - 0.16 11.9 0.1 0.5 10.3 0.0 1.9 2 0 0 2 2 2 0 NACHT domain DUF4798 PF16055.5 AAS50253.1 - 0.17 12.1 1.8 0.31 11.3 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) HIT PF01230.23 AAS50254.1 - 2.2e-14 54.0 4.2 6.9e-14 52.4 4.2 1.9 1 1 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AAS50254.1 - 2.4e-14 53.8 9.3 3.3e-13 50.1 9.3 2.2 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 AAS50254.1 - 3.4e-13 49.8 0.6 6.3e-12 45.8 0.1 2.7 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger zf-BED PF02892.15 AAS50254.1 - 0.0052 16.8 3.0 1.1 9.4 0.2 2.7 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_4 PF13894.6 AAS50254.1 - 0.12 13.3 0.1 0.12 13.3 0.1 4.6 5 1 0 5 5 5 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 AAS50254.1 - 0.4 10.6 5.3 0.39 10.7 1.1 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 AAS50254.1 - 1.4 9.2 5.4 19 5.6 0.5 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding FYVE PF01363.21 AAS50254.1 - 2.3 8.4 6.1 5.9 7.1 0.2 2.5 2 0 0 2 2 2 0 FYVE zinc finger Stc1 PF12898.7 AAS50254.1 - 2.3 8.8 5.1 18 6.0 0.2 2.6 2 1 0 2 2 2 0 Stc1 domain Sgf11 PF08209.11 AAS50254.1 - 4.4 6.9 6.9 1.6 8.3 0.4 2.6 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) EF-hand_7 PF13499.6 AAS50256.1 - 9.6e-28 96.4 12.3 6.1e-16 58.6 1.7 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 AAS50256.1 - 1e-27 93.5 16.9 1.4e-08 33.7 0.2 4.2 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 AAS50256.1 - 4.3e-22 76.1 13.0 9.2e-08 31.4 0.3 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 AAS50256.1 - 1.7e-19 69.4 15.2 1.4e-10 40.8 0.7 3.8 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 AAS50256.1 - 1.8e-13 49.3 10.5 2.8e-05 23.4 0.1 4.2 4 0 0 4 4 4 3 EF hand EF-hand_4 PF12763.7 AAS50256.1 - 1e-08 35.0 2.0 0.00028 20.8 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AAS50256.1 - 1.6e-08 34.8 1.2 6.9e-05 23.1 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 AAS50256.1 - 0.00027 21.2 0.8 0.086 13.2 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 AAS50256.1 - 0.00083 19.7 1.4 0.096 13.0 0.1 2.1 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 AAS50256.1 - 0.01 16.0 0.4 2.9 8.2 0.1 2.7 2 0 0 2 2 2 0 Dockerin type I domain SUB1_ProdP9 PF18213.1 AAS50256.1 - 0.011 15.5 0.2 0.025 14.4 0.2 1.7 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Caleosin PF05042.13 AAS50256.1 - 0.015 15.2 1.2 1.2 9.1 0.1 3.1 1 1 3 4 4 4 0 Caleosin related protein DUF1296 PF06972.11 AAS50256.1 - 0.029 14.5 0.6 2.4 8.4 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1296) VCBS PF13517.6 AAS50256.1 - 0.042 14.4 0.2 1.4 9.5 0.0 2.4 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella MgtE_N PF03448.17 AAS50256.1 - 0.072 13.7 1.8 0.18 12.4 0.2 2.3 3 0 0 3 3 3 0 MgtE intracellular N domain PhetRS_B1 PF18262.1 AAS50256.1 - 0.1 12.8 0.5 0.1 12.8 0.5 2.0 2 1 1 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain FG-GAP PF01839.23 AAS50256.1 - 1.9 8.7 4.2 3.8 7.7 0.1 2.4 2 0 0 2 2 2 0 FG-GAP repeat CAP_GLY PF01302.25 AAS50257.1 - 5.8e-20 71.1 1.0 9.1e-20 70.5 1.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain UPF0160 PF03690.13 AAS50257.1 - 0.069 12.8 4.1 0.087 12.5 2.6 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0160) Vip3A_N PF12495.8 AAS50257.1 - 0.82 9.5 12.9 0.21 11.5 8.3 2.3 2 0 0 2 2 2 0 Vegetative insecticide protein 3A N terminal Corona_S2 PF01601.16 AAS50257.1 - 1.9 6.9 8.1 2.3 6.6 6.8 1.8 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein Sec20 PF03908.13 AAS50257.1 - 9.3 6.2 17.8 12 5.9 2.9 4.2 3 0 0 3 3 3 0 Sec20 PIGA PF08288.12 AAS50258.1 - 1.6e-44 150.4 1.9 1.6e-44 150.4 1.9 2.3 2 0 0 2 2 2 1 PIGA (GPI anchor biosynthesis) Glyco_transf_4 PF13439.6 AAS50258.1 - 2.5e-29 102.4 0.6 2.5e-29 102.4 0.6 2.1 3 0 0 3 3 3 1 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 AAS50258.1 - 4.3e-26 91.5 0.0 6.8e-26 90.8 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AAS50258.1 - 2.3e-20 73.4 0.1 5.7e-20 72.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AAS50258.1 - 9.2e-13 48.9 0.0 2.3e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 AAS50258.1 - 0.002 18.5 0.0 0.0036 17.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 AAS50258.1 - 0.019 14.7 0.5 0.38 10.4 0.0 2.5 2 1 1 3 3 3 0 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.6 AAS50258.1 - 0.04 13.9 0.3 0.096 12.7 0.3 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like TFR_dimer PF04253.15 AAS50259.1 - 8.3e-25 87.2 0.1 2e-24 86.0 0.1 1.6 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain PA PF02225.22 AAS50259.1 - 0.0044 17.0 0.0 0.015 15.3 0.0 1.9 1 1 0 1 1 1 1 PA domain Peptidase_M28 PF04389.17 AAS50259.1 - 0.024 14.3 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M28 Cyt-b5 PF00173.28 AAS50260.1 - 4.2e-14 52.5 0.0 5.7e-14 52.0 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain RRM_9 PF18444.1 AAS50262.1 - 2.5e-28 97.7 0.3 4.8e-28 96.8 0.3 1.5 1 0 0 1 1 1 1 RNA recognition motif TAP_C PF03943.13 AAS50262.1 - 3.1e-13 49.1 0.1 3.1e-13 49.1 0.1 2.3 2 0 0 2 2 2 1 TAP C-terminal domain LRR_9 PF14580.6 AAS50262.1 - 3.8e-09 36.3 1.1 6.8e-09 35.5 1.1 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 AAS50262.1 - 8.5e-05 22.8 11.1 0.0012 19.2 2.9 2.9 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) DnaJ PF00226.31 AAS50263.1 - 7.3e-15 54.8 0.2 2e-14 53.4 0.2 1.8 1 0 0 1 1 1 1 DnaJ domain Sec63 PF02889.16 AAS50263.1 - 0.039 13.1 0.0 0.49 9.5 0.0 2.2 2 0 0 2 2 2 0 Sec63 Brl domain Acetyltransf_10 PF13673.7 AAS50264.1 - 5.3e-12 45.8 0.1 6.8e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AAS50264.1 - 7.8e-11 42.2 0.0 9.4e-11 42.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS50264.1 - 1.5e-10 41.4 0.1 2.2e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AAS50264.1 - 0.00095 19.3 0.0 0.0011 19.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PanZ PF12568.8 AAS50264.1 - 0.027 14.2 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_CG PF14542.6 AAS50264.1 - 0.029 14.5 0.0 0.044 13.9 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Acetyltransf_13 PF13880.6 AAS50264.1 - 0.12 12.3 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase DUF4177 PF13783.6 AAS50265.1 - 0.013 15.7 0.0 0.031 14.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4177) Tma16 PF11176.8 AAS50266.1 - 6.3e-48 162.4 5.9 7.5e-48 162.1 5.9 1.1 1 0 0 1 1 1 1 Translation machinery-associated protein 16 UPF0767 PF15990.5 AAS50266.1 - 0.2 11.8 1.3 0.68 10.1 0.7 2.0 2 0 0 2 2 2 0 UPF0767 family DNA_pol_B PF00136.21 AAS50267.2 - 4.3e-102 342.2 0.0 5.9e-102 341.7 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AAS50267.2 - 3.1e-20 72.6 0.0 3.7e-15 55.9 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AAS50267.2 - 7.8e-10 39.1 9.9 1.6e-09 38.1 9.9 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta Glyco_hydro_64 PF16483.5 AAS50267.2 - 0.15 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Beta-1,3-glucanase Atg29_N PF18388.1 AAS50268.1 - 1.3e-21 76.1 0.9 2.2e-21 75.4 0.9 1.4 1 0 0 1 1 1 1 Atg29 N-terminal domain Siah-Interact_N PF09032.11 AAS50268.1 - 0.023 15.0 0.0 0.046 14.0 0.0 1.5 1 0 0 1 1 1 0 Siah interacting protein, N terminal SET PF00856.28 AAS50269.1 - 4e-12 46.9 0.0 9.3e-12 45.7 0.0 1.6 1 1 0 1 1 1 1 SET domain zf-FCS PF06467.14 AAS50269.1 - 0.25 11.3 0.1 0.25 11.3 0.1 2.3 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif Rhodanese PF00581.20 AAS50270.1 - 2.3e-19 69.9 0.0 2.6e-08 34.3 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain CLP1_P PF16575.5 AAS50271.1 - 7.4e-29 100.9 0.0 1.3e-28 100.1 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Clp1 PF06807.14 AAS50271.1 - 8.5e-27 93.9 0.0 1.5e-26 93.1 0.0 1.4 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_N PF16573.5 AAS50271.1 - 5.8e-24 84.1 0.0 1.2e-23 83.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor ATP_bind_1 PF03029.17 AAS50271.1 - 0.00077 19.3 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 AAS50271.1 - 0.0027 18.1 0.0 0.0056 17.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AAS50271.1 - 0.0071 16.9 0.0 0.039 14.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 AAS50271.1 - 0.026 14.3 0.0 0.077 12.7 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_7 PF12775.7 AAS50271.1 - 0.073 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region Roc PF08477.13 AAS50271.1 - 0.19 11.9 0.0 0.42 10.9 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase ANAPC5 PF12862.7 AAS50272.1 - 2e-20 72.7 6.1 5.7e-20 71.2 0.0 3.6 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 5 RPN7 PF10602.9 AAS50272.1 - 0.076 12.7 1.5 1.5 8.5 0.0 2.6 2 1 0 2 2 2 0 26S proteasome subunit RPN7 HATPase_c_3 PF13589.6 AAS50273.1 - 1.3e-07 31.5 0.0 2.5e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MutL_C PF08676.11 AAS50273.1 - 1.3e-07 31.5 0.0 1.1e-06 28.4 0.0 2.2 1 1 1 2 2 2 1 MutL C terminal dimerisation domain HATPase_c PF02518.26 AAS50273.1 - 5e-07 30.2 0.0 9.1e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 AAS50273.1 - 0.026 14.2 0.0 0.059 13.0 0.0 1.5 1 0 0 1 1 1 0 DNA mismatch repair protein, C-terminal domain ATXN-1_C PF12547.8 AAS50273.1 - 0.034 14.5 0.1 0.082 13.3 0.1 1.6 1 0 0 1 1 1 0 Capicua transcriptional repressor modulator SPX PF03105.19 AAS50274.1 - 0.21 11.5 4.4 0.23 11.3 4.4 1.1 1 0 0 1 1 1 0 SPX domain STIMATE PF12400.8 AAS50275.1 - 1.4e-42 145.2 5.1 1.4e-42 145.2 5.1 1.6 2 0 0 2 2 2 1 STIMATE family NADH_dh_m_C1 PF15088.6 AAS50275.1 - 0.19 11.4 0.6 0.37 10.5 0.6 1.4 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial adh_short PF00106.25 AAS50277.1 - 2.1e-28 99.1 0.0 3.3e-15 56.1 0.0 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 AAS50277.1 - 9.5e-17 61.3 0.0 1.2e-12 48.0 0.0 3.0 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS50277.1 - 3.1e-05 23.9 0.0 6e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 KR domain PLU-1 PF08429.11 AAS50277.1 - 0.073 12.2 0.1 0.1 11.7 0.1 1.1 1 0 0 1 1 1 0 PLU-1-like protein Epimerase PF01370.21 AAS50277.1 - 0.085 12.3 0.1 0.18 11.3 0.1 1.6 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2670 PF10875.8 AAS50277.1 - 0.13 12.4 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) GDP_Man_Dehyd PF16363.5 AAS50277.1 - 0.13 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase tRNA-synt_1 PF00133.22 AAS50278.2 - 1.3e-43 149.2 0.0 4e-34 117.8 0.0 2.5 2 1 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AAS50278.2 - 4.8e-18 65.1 1.2 1.2e-08 34.1 0.0 4.0 5 0 0 5 5 5 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AAS50278.2 - 4.4e-11 43.0 0.0 1.4e-10 41.3 0.0 1.9 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AAS50278.2 - 7.5e-07 28.8 0.0 1.6e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF836 PF05768.14 AAS50280.1 - 4.7e-19 68.6 0.3 6.4e-19 68.1 0.3 1.2 1 0 0 1 1 1 1 Glutaredoxin-like domain (DUF836) Glutaredoxin PF00462.24 AAS50280.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutaredoxin ERM PF00769.19 AAS50281.2 - 0.001 18.9 19.5 0.001 18.9 19.5 4.2 1 1 3 4 4 4 2 Ezrin/radixin/moesin family SlyX PF04102.12 AAS50281.2 - 0.033 14.8 2.2 0.033 14.8 2.2 8.4 5 2 3 9 9 9 0 SlyX HrpB7 PF09486.10 AAS50281.2 - 0.84 10.0 26.4 0.32 11.4 1.1 5.1 4 2 0 4 4 4 0 Bacterial type III secretion protein (HrpB7) Golgin_A5 PF09787.9 AAS50281.2 - 4.1 6.8 76.4 0.024 14.1 15.0 4.9 1 1 5 6 6 6 0 Golgin subfamily A member 5 PAP2 PF01569.21 AAS50282.1 - 3.7e-25 88.3 0.4 3.7e-25 88.3 0.4 1.8 2 0 0 2 2 2 1 PAP2 superfamily SLATT_1 PF18181.1 AAS50282.1 - 0.16 11.9 0.1 0.35 10.8 0.1 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 DUF4191 PF13829.6 AAS50282.1 - 0.42 9.9 2.7 0.43 9.9 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) PAP2_3 PF14378.6 AAS50282.1 - 0.43 10.3 10.9 11 5.6 10.9 2.3 1 1 0 1 1 1 0 PAP2 superfamily EamA PF00892.20 AAS50282.1 - 3.6 7.8 10.2 8.9 6.5 1.7 2.5 2 0 0 2 2 2 0 EamA-like transporter family HGTP_anticodon2 PF12745.7 AAS50283.1 - 9.1e-88 294.2 1.2 9.1e-88 294.2 1.2 2.2 2 0 0 2 2 2 1 Anticodon binding domain of tRNAs Pkinase PF00069.25 AAS50283.1 - 3.2e-70 236.5 10.1 9.9e-43 146.4 0.1 4.2 4 1 0 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50283.1 - 7.1e-39 133.6 0.5 2e-20 73.1 0.0 3.6 3 1 0 3 3 3 3 Protein tyrosine kinase RWD PF05773.22 AAS50283.1 - 1.5e-17 63.9 0.2 7.7e-17 61.6 0.2 2.4 2 0 0 2 2 2 1 RWD domain tRNA-synt_His PF13393.6 AAS50283.1 - 8.4e-14 51.6 0.1 2.3e-13 50.1 0.0 1.8 2 0 0 2 2 2 1 Histidyl-tRNA synthetase FTA2 PF13095.6 AAS50283.1 - 0.015 14.9 0.9 2.6 7.6 0.0 3.3 3 0 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AAS50283.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family HGTP_anticodon PF03129.20 AAS50283.1 - 0.34 11.1 0.0 0.34 11.1 0.0 2.6 3 0 0 3 3 3 0 Anticodon binding domain Kinase-like PF14531.6 AAS50283.1 - 1.4 8.1 4.9 1.1 8.5 0.0 2.7 3 0 0 3 3 3 0 Kinase-like Med20 PF08612.11 AAS50284.1 - 3.8e-51 173.6 0.1 4.2e-51 173.5 0.1 1.0 1 0 0 1 1 1 1 TATA-binding related factor (TRF) of subunit 20 of Mediator complex Ribosomal_L30 PF00327.20 AAS50284.1 - 0.0068 16.3 0.1 0.019 14.9 0.1 1.7 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e CTD_bind PF04818.13 AAS50285.1 - 2.1e-16 60.5 1.8 3.3e-16 59.8 0.7 2.0 2 0 0 2 2 2 1 RNA polymerase II-binding domain. CNOT1_CAF1_bind PF16415.5 AAS50285.1 - 0.013 14.9 0.2 0.013 14.9 0.2 1.7 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CTK3 PF12243.8 AAS50285.1 - 0.043 13.8 0.7 0.13 12.2 0.0 2.0 2 1 1 3 3 3 0 CTD kinase subunit gamma CTK3 Fib_alpha PF08702.10 AAS50285.1 - 0.11 12.7 2.1 0.18 12.0 0.5 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DEAD PF00270.29 AAS50286.1 - 1.3e-24 86.9 0.0 2.4e-24 86.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.10 AAS50286.1 - 3.8e-19 69.2 0.1 9e-19 68.0 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 AAS50286.1 - 1.8e-13 50.8 0.3 2.8e-12 47.0 0.1 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS50286.1 - 8.3e-08 32.4 0.0 1.4e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit CDT1 PF08839.11 AAS50286.1 - 0.057 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 DNA replication factor CDT1 like SRP54 PF00448.22 AAS50287.2 - 1.3e-48 165.2 0.4 1.2e-29 103.3 0.1 2.4 1 1 1 2 2 2 2 SRP54-type protein, GTPase domain SRX PF09201.10 AAS50287.2 - 5.2e-32 110.7 0.1 1.1e-31 109.6 0.1 1.6 1 0 0 1 1 1 1 SRX, signal recognition particle receptor alpha subunit SRP-alpha_N PF04086.13 AAS50287.2 - 1.5e-07 31.7 1.1 2.8e-07 30.8 1.1 1.4 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal SRP54_N PF02881.19 AAS50287.2 - 2.7e-06 27.5 0.0 1.3e-05 25.3 0.0 2.2 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain MeaB PF03308.16 AAS50287.2 - 0.00026 20.1 0.0 0.00073 18.6 0.0 1.7 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 AAS50287.2 - 0.00077 18.7 0.2 0.059 12.5 0.2 2.3 1 1 0 1 1 1 1 Anion-transporting ATPase cobW PF02492.19 AAS50287.2 - 0.0014 18.2 0.1 0.003 17.2 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AAS50287.2 - 0.0015 18.6 0.0 0.0068 16.5 0.0 2.0 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AAS50287.2 - 0.0029 17.5 0.1 0.017 15.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS50287.2 - 0.0035 17.1 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AAS50287.2 - 0.015 15.3 0.2 0.18 11.9 0.2 2.5 2 1 0 2 2 2 0 50S ribosome-binding GTPase Fer4_NifH PF00142.18 AAS50287.2 - 0.018 14.5 0.0 0.028 13.9 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AAA_22 PF13401.6 AAS50287.2 - 0.025 14.8 0.0 0.13 12.6 0.0 2.2 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 AAS50287.2 - 0.053 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 AAS50287.2 - 0.066 12.6 0.0 0.14 11.5 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 AAS50287.2 - 0.075 12.6 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 AAS50287.2 - 0.1 13.0 0.2 6.3 7.2 0.2 2.7 1 1 0 1 1 1 0 AAA domain DUF87 PF01935.17 AAS50287.2 - 0.53 10.3 2.2 2.3 8.3 0.5 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain Cyt-b5 PF00173.28 AAS50288.1 - 8.1e-14 51.5 0.0 2.2e-13 50.1 0.0 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain zf-HIT PF04438.16 AAS50289.1 - 2e-07 30.7 15.1 3.3e-07 30.0 15.1 1.4 1 0 0 1 1 1 1 HIT zinc finger BUD22 PF09073.10 AAS50289.1 - 0.72 9.1 6.7 1 8.6 6.7 1.2 1 0 0 1 1 1 0 BUD22 V-ATPase_G PF03179.15 AAS50290.1 - 9.2e-32 109.7 12.7 1e-31 109.6 12.7 1.0 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit DUF3552 PF12072.8 AAS50290.1 - 0.0012 18.3 8.0 0.0012 18.3 8.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF3552) ASL_C2 PF14698.6 AAS50290.1 - 0.012 16.4 1.6 0.03 15.1 1.6 1.8 1 1 0 1 1 1 0 Argininosuccinate lyase C-terminal FlgN PF05130.12 AAS50290.1 - 0.13 12.8 7.7 0.14 12.6 7.7 1.1 1 0 0 1 1 1 0 FlgN protein V-ATPase_G_2 PF16999.5 AAS50290.1 - 0.37 11.2 17.7 0.51 10.8 17.7 1.2 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit ATP-synt_B PF00430.18 AAS50290.1 - 0.77 9.8 20.1 3.8 7.6 20.1 1.9 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) Aldedh PF00171.22 AAS50291.1 - 2.7e-127 425.1 0.0 3.4e-127 424.8 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3322 PF11795.8 AAS50291.1 - 0.088 12.8 0.1 0.18 11.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) RRF PF01765.19 AAS50292.1 - 1.2e-35 122.8 6.2 1.2e-35 122.8 6.2 1.5 2 0 0 2 2 2 1 Ribosome recycling factor DUF2884 PF11101.8 AAS50292.1 - 0.0047 16.5 0.8 0.0047 16.5 0.8 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2884) Sec5 PF15469.6 AAS50292.1 - 0.0055 16.5 1.4 0.01 15.7 1.4 1.5 1 0 0 1 1 1 1 Exocyst complex component Sec5 DUF16 PF01519.16 AAS50292.1 - 0.081 13.4 7.0 0.061 13.8 4.2 2.0 2 0 0 2 2 2 0 Protein of unknown function DUF16 Aminotran_1_2 PF00155.21 AAS50292.1 - 0.11 11.7 1.3 0.22 10.6 0.0 2.0 2 1 0 2 2 2 0 Aminotransferase class I and II DASH_Duo1 PF08651.10 AAS50292.1 - 0.16 11.8 2.9 0.23 11.2 1.6 1.9 2 0 0 2 2 2 0 DASH complex subunit Duo1 ART-PolyVal PF18760.1 AAS50292.1 - 0.36 11.9 2.4 15 6.7 0.3 2.1 2 0 0 2 2 2 0 ADP-Ribosyltransferase in polyvalent proteins Ribosomal_L22 PF00237.19 AAS50292.1 - 0.62 10.3 4.6 17 5.7 1.6 2.5 1 1 1 2 2 2 0 Ribosomal protein L22p/L17e IZUMO PF15005.6 AAS50292.1 - 0.99 9.9 8.4 0.49 10.9 4.9 2.3 2 2 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated TPP_enzyme_N PF02776.18 AAS50293.1 - 2.3e-32 112.0 0.0 4.4e-32 111.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS50293.1 - 1.5e-26 92.8 0.0 2e-25 89.1 0.0 2.6 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AAS50293.1 - 1.6e-13 50.7 0.0 3.4e-13 49.7 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RNB PF00773.19 AAS50294.1 - 6e-55 186.8 0.0 9.8e-55 186.2 0.0 1.3 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 AAS50294.1 - 2.3e-24 85.2 0.2 6.6e-24 83.7 0.1 1.9 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) Dis3l2_C_term PF17877.1 AAS50294.1 - 3e-22 78.7 0.0 9.2e-22 77.2 0.0 1.9 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal CSD2 PF17876.1 AAS50294.1 - 6.7e-07 29.4 0.3 0.00032 20.8 0.0 3.2 4 0 0 4 4 4 1 Cold shock domain Rrp44_CSD1 PF17216.3 AAS50294.1 - 0.00025 20.8 0.1 0.00068 19.4 0.1 1.7 1 0 0 1 1 1 1 Rrp44-like cold shock domain OB_RNB PF08206.11 AAS50294.1 - 0.0051 16.5 0.1 0.66 9.7 0.1 2.6 2 0 0 2 2 2 1 Ribonuclease B OB domain NPR3 PF03666.13 AAS50294.1 - 0.06 12.1 1.8 0.11 11.2 1.8 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Aldedh PF00171.22 AAS50295.1 - 6.1e-102 341.5 0.0 7.4e-102 341.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Brr6_like_C_C PF10104.9 AAS50296.2 - 1.5e-42 144.6 0.1 2.1e-42 144.1 0.1 1.2 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Arena_RNA_pol PF06317.11 AAS50296.2 - 0.077 10.2 0.0 0.1 9.8 0.0 1.0 1 0 0 1 1 1 0 Arenavirus RNA polymerase HDA2-3 PF11496.8 AAS50297.1 - 3.7e-69 233.1 0.0 7.2e-69 232.2 0.0 1.4 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Atg14 PF10186.9 AAS50297.1 - 0.18 10.8 15.1 0.33 10.0 15.1 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med9 PF07544.13 AAS50297.1 - 0.67 10.1 6.1 1.2 9.3 1.1 2.9 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4407 PF14362.6 AAS50297.1 - 0.7 9.2 20.8 0.25 10.6 11.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) YabA PF06156.13 AAS50297.1 - 1.4 9.6 14.6 0.14 12.8 1.8 3.6 2 1 1 3 3 3 0 Initiation control protein YabA Mod_r PF07200.13 AAS50297.1 - 1.5 9.0 22.8 0.043 13.9 6.6 3.8 3 1 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF4201 PF13870.6 AAS50297.1 - 1.6 8.4 19.7 0.38 10.5 9.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) ATG16 PF08614.11 AAS50297.1 - 2.2 8.4 30.5 4.7 7.4 19.5 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Fmp27_WPPW PF10359.9 AAS50297.1 - 3 6.6 21.0 0.35 9.7 1.8 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain ALMT PF11744.8 AAS50297.1 - 3.3 6.4 7.5 6 5.6 7.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec23_trunk PF04811.15 AAS50298.2 - 5.1e-11 42.6 0.0 4.1e-10 39.6 0.0 2.0 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AAS50298.2 - 8.9e-05 23.2 0.0 0.00018 22.2 0.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 AAS50298.2 - 0.0059 16.6 3.0 0.011 15.7 3.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 AAS50298.2 - 0.046 13.5 0.0 0.13 12.0 0.0 1.9 1 1 0 1 1 1 0 Sec23/Sec24 helical domain Mhr1 PF12829.7 AAS50299.1 - 4.8e-24 84.3 0.2 9.8e-24 83.3 0.2 1.5 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination FA_hydroxylase PF04116.13 AAS50300.1 - 1.9e-20 73.5 13.3 1.9e-20 73.5 13.3 2.1 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily EF-hand_like PF09279.11 AAS50300.1 - 0.15 12.6 0.5 0.29 11.6 0.5 1.4 1 0 0 1 1 1 0 Phosphoinositide-specific phospholipase C, efhand-like OSCP PF00213.18 AAS50301.1 - 5.7e-42 143.8 1.4 6.6e-42 143.6 1.4 1.0 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Lipoprotein_20 PF13942.6 AAS50301.1 - 0.18 11.7 0.0 0.24 11.3 0.0 1.2 1 0 0 1 1 1 0 YfhG lipoprotein TRAUB PF08164.12 AAS50302.1 - 6.2e-25 87.5 0.9 6.1e-24 84.3 0.1 2.9 2 0 0 2 2 2 1 Apoptosis-antagonizing transcription factor, C-terminal AATF-Che1 PF13339.6 AAS50302.1 - 5.3e-21 75.8 1.4 5.3e-21 75.8 1.4 2.7 3 1 0 3 3 3 1 Apoptosis antagonizing transcription factor Anophelin PF10731.9 AAS50302.1 - 3.4 7.6 0.0 3.4 7.6 0.0 3.6 3 0 0 3 3 3 0 Thrombin inhibitor from mosquito MatE PF01554.18 AAS50303.1 - 3.5e-43 147.0 40.0 4.4e-25 88.2 16.2 2.6 3 0 0 3 3 3 2 MatE Polysacc_synt_C PF14667.6 AAS50303.1 - 1.7e-06 28.1 3.6 1.7e-06 28.1 3.6 4.5 4 1 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain PIH1 PF08190.12 AAS50304.1 - 2.7e-23 82.2 0.1 4.3e-23 81.6 0.1 1.2 1 0 0 1 1 1 1 PIH1 N-terminal domain Pih1_fungal_CS PF18482.1 AAS50304.1 - 7.3e-23 80.9 0.0 1.4e-22 80.0 0.0 1.5 1 0 0 1 1 1 1 Fungal Pih1 CS domain AA_kinase PF00696.28 AAS50305.1 - 3.6e-35 121.7 0.1 6.7e-35 120.8 0.1 1.4 1 0 0 1 1 1 1 Amino acid kinase family PUA PF01472.20 AAS50305.1 - 4.7e-20 71.3 0.2 1.3e-19 69.9 0.2 1.8 1 0 0 1 1 1 1 PUA domain CPSF_A PF03178.15 AAS50306.1 - 1.4e-91 307.2 0.1 4.9e-91 305.4 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region G-7-MTase PF12803.7 AAS50306.1 - 0.045 12.9 0.0 0.085 12.0 0.0 1.4 1 0 0 1 1 1 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) HPS3_N PF14761.6 AAS50306.1 - 0.2 11.2 2.4 9.5 5.7 0.0 3.2 4 0 0 4 4 4 0 Hermansky-Pudlak syndrome 3 PIG-F PF06699.11 AAS50307.1 - 5.1e-24 85.4 17.8 7.4e-23 81.6 17.8 2.1 1 1 0 1 1 1 1 GPI biosynthesis protein family Pig-F AIM24 PF01987.17 AAS50308.1 - 2e-14 53.9 0.0 3.1e-14 53.2 0.0 1.3 1 1 0 1 1 1 1 Mitochondrial biogenesis AIM24 Zn_clus PF00172.18 AAS50309.1 - 5.4e-08 32.8 7.2 5.4e-08 32.8 7.2 1.9 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF4618 PF15397.6 AAS50309.1 - 0.051 13.0 1.3 0.13 11.6 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Pro_isomerase PF00160.21 AAS50310.1 - 1.1e-45 155.7 0.0 1.3e-45 155.5 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med6 PF04934.14 AAS50311.1 - 9.2e-52 174.4 0.1 1.1e-51 174.1 0.1 1.1 1 0 0 1 1 1 1 MED6 mediator sub complex component DUF2437 PF10370.9 AAS50311.1 - 0.039 14.8 0.0 0.21 12.5 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2437) IGR PF09597.10 AAS50312.1 - 2.7e-25 88.2 0.2 4.6e-25 87.5 0.2 1.4 1 0 0 1 1 1 1 IGR protein motif HIT PF01230.23 AAS50313.2 - 2.5e-24 85.8 0.1 3.7e-24 85.3 0.1 1.2 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AAS50313.2 - 0.0018 18.8 0.1 0.0026 18.2 0.1 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding F-box-like PF12937.7 AAS50314.1 - 0.0097 15.8 1.4 0.029 14.3 1.4 1.9 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS50314.1 - 0.017 15.0 0.0 1.3 9.0 0.4 3.2 3 1 0 3 3 3 0 F-box domain F-box-like_2 PF13013.6 AAS50314.1 - 0.07 13.1 0.0 0.31 11.0 0.0 2.1 2 1 0 2 2 2 0 F-box-like domain FNIP PF05725.12 AAS50314.1 - 0.1 12.7 0.3 0.56 10.4 0.0 2.5 4 0 0 4 4 4 0 FNIP Repeat DUF4199 PF13858.6 AAS50315.1 - 0.00088 19.7 0.3 0.0021 18.5 0.3 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) MIR PF02815.19 AAS50316.2 - 2.5e-21 76.4 0.0 3.9e-21 75.8 0.0 1.2 1 0 0 1 1 1 1 MIR domain PMT PF02366.18 AAS50316.2 - 9.2e-15 54.9 13.5 9.2e-15 54.9 13.5 1.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Med21 PF11221.8 AAS50317.1 - 9.9e-38 129.6 6.6 1.2e-37 129.3 6.6 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Med9 PF07544.13 AAS50317.1 - 0.0012 18.9 4.7 0.0083 16.2 0.1 3.1 3 1 1 4 4 4 1 RNA polymerase II transcription mediator complex subunit 9 Dynactin_p22 PF07426.11 AAS50317.1 - 0.0034 17.2 3.9 0.009 15.9 3.9 1.6 1 1 0 1 1 1 1 Dynactin subunit p22 Dynamin_N PF00350.23 AAS50317.1 - 0.048 13.7 2.6 0.044 13.8 0.6 1.6 1 1 1 2 2 2 0 Dynamin family Lebercilin PF15619.6 AAS50317.1 - 0.083 12.5 4.6 0.49 10.0 0.7 2.3 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease LidA_Long_CC PF18641.1 AAS50317.1 - 0.13 12.3 4.4 1.3 9.0 0.5 2.8 2 1 1 3 3 3 0 LidA long coiled-coil domain Tropomyosin PF00261.20 AAS50317.1 - 0.13 11.6 6.2 0.25 10.7 4.8 1.8 1 1 0 1 1 1 0 Tropomyosin DUF1492 PF07374.11 AAS50317.1 - 1.7 8.9 5.7 17 5.7 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1492) RNase_P_p30 PF01876.16 AAS50320.1 - 3.5e-65 219.5 0.0 4.1e-65 219.3 0.0 1.0 1 0 0 1 1 1 1 RNase P subunit p30 AP_endonuc_2 PF01261.24 AAS50320.1 - 0.098 12.1 0.4 0.31 10.4 0.3 1.9 1 1 1 2 2 2 0 Xylose isomerase-like TIM barrel Baculo_PEP_C PF04513.12 AAS50321.1 - 0.81 9.7 6.8 0.15 12.1 2.9 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Bacillus_HBL PF05791.11 AAS50321.1 - 2 8.2 7.8 0.32 10.8 1.9 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ApbA PF02558.16 AAS50322.1 - 3.3e-33 114.5 0.0 4.5e-33 114.1 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA ApbA_C PF08546.11 AAS50322.1 - 3.2e-28 98.4 0.0 5.1e-28 97.8 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal HSP70 PF00012.20 AAS50323.2 - 1.1e-77 261.7 2.5 3.3e-76 256.7 1.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AAS50323.2 - 7.8e-09 34.8 0.0 1.2e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein BSD PF03909.17 AAS50324.1 - 6e-21 74.2 4.7 2e-11 43.7 0.6 3.0 3 0 0 3 3 3 2 BSD domain PH_TFIIH PF08567.11 AAS50324.1 - 6.5e-20 71.3 0.1 1.6e-19 70.0 0.1 1.7 1 0 0 1 1 1 1 TFIIH p62 subunit, N-terminal domain DEAD PF00270.29 AAS50325.2 - 8.5e-50 168.9 0.0 1.5e-49 168.1 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS50325.2 - 2e-30 105.4 0.1 1e-29 103.1 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS50325.2 - 1.2e-06 28.6 0.1 4.9e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AAS50325.2 - 0.00088 19.6 0.0 0.006 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain ERCC3_RAD25_C PF16203.5 AAS50325.2 - 0.058 12.6 0.0 0.058 12.6 0.0 2.1 2 0 0 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Brix PF04427.18 AAS50326.1 - 2.4e-52 177.9 0.2 4e-52 177.1 0.2 1.4 1 0 0 1 1 1 1 Brix domain DUF2514 PF10721.9 AAS50326.1 - 1.2 9.2 11.3 0.14 12.2 3.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) FYVE PF01363.21 AAS50327.1 - 1.1e-16 60.7 12.7 1.1e-16 60.7 12.7 2.9 3 2 0 3 3 3 1 FYVE zinc finger zf-RING_2 PF13639.6 AAS50327.1 - 5.3e-08 33.1 2.6 5.3e-08 33.1 2.6 4.3 4 1 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 AAS50327.1 - 7.2e-06 25.9 1.1 7.2e-06 25.9 1.1 3.8 3 2 0 3 3 3 1 RING-type zinc-finger zf-RING_11 PF17123.5 AAS50327.1 - 6e-05 22.7 4.9 6e-05 22.7 4.9 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 AAS50327.1 - 0.00029 20.6 2.2 0.00029 20.6 2.2 5.2 4 2 2 6 6 6 1 Zinc finger, C3HC4 type (RING finger) RNF220 PF15926.5 AAS50327.1 - 0.019 14.6 0.6 0.038 13.6 0.6 1.5 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 zf-RING_5 PF14634.6 AAS50327.1 - 0.039 13.9 1.5 0.039 13.9 1.5 4.4 4 1 1 5 5 5 0 zinc-RING finger domain MaoC_dehydrat_N PF13452.6 AAS50328.1 - 5.8e-06 26.5 0.0 0.013 15.6 0.0 2.3 2 0 0 2 2 2 2 N-terminal half of MaoC dehydratase MaoC_dehydratas PF01575.19 AAS50328.1 - 0.0054 16.3 0.0 0.01 15.4 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain Ins_P5_2-kin PF06090.12 AAS50329.1 - 3.4e-19 69.5 0.0 8e-19 68.2 0.0 1.6 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase DS PF01916.17 AAS50330.1 - 1.8e-131 437.6 0.0 2.1e-131 437.4 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase Methyltransf_23 PF13489.6 AAS50331.1 - 2.3e-21 76.3 0.0 5.1e-21 75.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS50331.1 - 8.3e-12 45.7 0.0 3.3e-11 43.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS50331.1 - 6.3e-11 42.8 0.0 4.7e-08 33.6 0.0 2.7 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AAS50331.1 - 3.4e-10 39.6 0.3 8.6e-05 22.0 0.0 2.8 2 1 1 3 3 3 2 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AAS50331.1 - 4.3e-10 40.1 0.0 1.5e-07 31.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS50331.1 - 6.6e-06 26.0 0.0 0.00012 21.9 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain DUF4435 PF14491.6 AAS50331.1 - 0.028 14.3 1.0 0.1 12.5 0.1 2.1 2 1 0 3 3 3 0 Protein of unknown function (DUF4435) N2227 PF07942.12 AAS50331.1 - 0.11 11.6 0.0 2.8 7.0 0.0 2.1 2 0 0 2 2 2 0 N2227-like protein Rol_Rep_N PF18106.1 AAS50331.1 - 0.19 12.0 0.7 0.91 9.9 0.3 2.2 1 1 1 2 2 2 0 Rolling Circle replication initiation protein N-terminal domain ECR1_N PF14382.6 AAS50332.1 - 1.7e-16 59.7 0.1 4.2e-16 58.5 0.1 1.8 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region KH_6 PF15985.5 AAS50332.1 - 6.9e-11 42.3 0.4 1.6e-10 41.2 0.4 1.6 1 0 0 1 1 1 1 KH domain EXOSC1 PF10447.9 AAS50332.1 - 0.1 13.2 0.4 29 5.3 0.0 3.0 3 1 1 4 4 4 0 Exosome component EXOSC1/CSL4 Met_10 PF02475.16 AAS50333.1 - 8.9e-71 237.8 0.0 1.3e-70 237.2 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MethyltransfD12 PF02086.15 AAS50333.1 - 0.027 14.1 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase MTS PF05175.14 AAS50333.1 - 0.041 13.4 0.0 0.28 10.7 0.0 2.2 2 1 1 3 3 3 0 Methyltransferase small domain TRM PF02005.16 AAS50333.1 - 0.15 11.2 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Cyclin_N PF00134.23 AAS50334.1 - 1.1e-08 34.9 0.2 1.5e-08 34.4 0.2 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AAS50334.1 - 0.00046 20.6 0.1 0.00064 20.1 0.1 1.2 1 0 0 1 1 1 1 Cyclin Nefa_Nip30_N PF10187.9 AAS50335.1 - 3.1e-05 24.3 8.3 3.1e-05 24.3 8.3 2.0 1 1 1 2 2 2 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 MRJP PF03022.16 AAS50335.1 - 0.097 12.0 2.3 0.12 11.7 2.3 1.1 1 0 0 1 1 1 0 Major royal jelly protein SNF2_N PF00176.23 AAS50336.2 - 1.8e-47 161.7 0.4 3.4e-47 160.9 0.4 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-RING_2 PF13639.6 AAS50336.2 - 1.1e-08 35.3 15.4 1.1e-08 35.3 15.4 2.1 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS50336.2 - 7.9e-08 32.0 14.4 2e-07 30.8 14.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS50336.2 - 5.3e-07 29.4 12.1 1.1e-06 28.4 12.1 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS50336.2 - 7.7e-07 28.9 14.9 2.2e-06 27.4 14.9 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AAS50336.2 - 1.8e-06 28.1 8.7 5.7e-06 26.5 8.7 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 AAS50336.2 - 2e-05 24.9 0.2 0.00012 22.4 0.2 2.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 AAS50336.2 - 4.9e-05 23.1 12.3 0.0001 22.1 12.3 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AAS50336.2 - 0.00036 20.5 12.0 0.00085 19.3 12.0 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AAS50336.2 - 0.00099 19.0 13.6 0.003 17.5 13.6 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 AAS50336.2 - 0.064 13.4 15.8 0.19 11.9 15.8 1.9 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 AAS50336.2 - 0.068 13.2 6.0 0.17 12.0 6.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 AAS50336.2 - 0.091 12.6 5.7 0.23 11.4 5.7 1.7 1 0 0 1 1 1 0 zf-RING of BARD1-type protein YabA PF06156.13 AAS50336.2 - 0.12 13.0 0.1 0.12 13.0 0.1 4.5 5 1 1 6 6 4 0 Initiation control protein YabA Prp19 PF08606.11 AAS50336.2 - 0.15 12.0 6.2 1.3 9.1 0.1 3.6 3 0 0 3 3 3 0 Prp19/Pso4-like Shikimate_DH PF01488.20 AAS50336.2 - 0.23 11.5 1.3 0.93 9.6 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase LAGLIDADG_WhiA PF14527.6 AAS50336.2 - 0.77 9.9 3.7 2.1 8.5 0.3 3.3 3 0 0 3 3 2 0 WhiA LAGLIDADG-like domain zf-RING_10 PF16685.5 AAS50336.2 - 0.85 9.8 7.9 1.6 8.9 6.7 2.1 2 0 0 2 2 1 0 zinc RING finger of MSL2 AMP-binding_C_2 PF14535.6 AAS50336.2 - 4.2 7.7 6.0 23 5.4 0.2 3.8 4 0 0 4 4 4 0 AMP-binding enzyme C-terminal domain zf-P11 PF03854.14 AAS50336.2 - 8.3 6.2 10.4 22 4.8 10.4 1.7 1 0 0 1 1 1 0 P-11 zinc finger Pkinase PF00069.25 AAS50337.1 - 2e-57 194.6 0.0 1.7e-56 191.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50337.1 - 4.3e-23 81.9 0.0 3.6e-19 69.1 0.0 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AAS50337.1 - 0.00015 21.2 0.1 0.42 9.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 AAS50337.1 - 0.00023 20.6 0.0 0.00041 19.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AAS50337.1 - 0.014 15.0 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ABC_tran PF00005.27 AAS50338.2 - 3e-44 150.9 0.1 1.7e-22 80.4 0.0 4.3 3 2 0 3 3 2 2 ABC transporter 4HB PF17947.1 AAS50338.2 - 1.4e-28 98.8 0.8 5.3e-28 96.9 0.0 2.5 2 0 0 2 2 1 1 Four helical bundle domain AAA_21 PF13304.6 AAS50338.2 - 3.8e-18 66.3 0.1 0.0037 17.1 0.0 4.9 5 0 0 5 5 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS50338.2 - 6.8e-16 58.4 0.0 1.5e-06 27.9 0.0 3.9 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AAS50338.2 - 9e-11 42.6 4.1 0.00025 21.6 0.1 3.5 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 AAS50338.2 - 1.2e-08 35.0 0.0 0.00015 21.7 0.0 2.8 2 0 0 2 2 2 2 RsgA GTPase AAA_29 PF13555.6 AAS50338.2 - 1.6e-08 34.2 0.0 0.0068 16.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AAS50338.2 - 5.3e-08 33.2 0.1 0.016 15.4 0.0 4.3 4 1 0 4 4 3 2 AAA domain AAA_28 PF13521.6 AAS50338.2 - 1.6e-07 31.7 0.0 0.004 17.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain MMR_HSR1 PF01926.23 AAS50338.2 - 1.9e-07 31.2 0.0 0.0021 18.1 0.0 3.0 2 0 0 2 2 2 2 50S ribosome-binding GTPase Dynamin_N PF00350.23 AAS50338.2 - 7.7e-07 29.3 0.0 2.5e-05 24.4 0.0 2.8 2 0 0 2 2 2 1 Dynamin family AAA PF00004.29 AAS50338.2 - 4.6e-06 27.1 0.0 0.81 10.1 0.0 4.3 4 0 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AAS50338.2 - 1.2e-05 25.8 0.1 0.34 11.4 0.0 3.3 3 0 0 3 3 2 2 AAA domain RNA_helicase PF00910.22 AAS50338.2 - 1.3e-05 25.5 0.0 0.12 12.7 0.0 2.9 2 0 0 2 2 2 2 RNA helicase MeaB PF03308.16 AAS50338.2 - 1.7e-05 23.9 0.1 0.15 11.0 0.0 2.4 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 AAS50338.2 - 2.3e-05 24.6 0.0 0.32 11.2 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 AAS50338.2 - 7.5e-05 23.2 0.0 0.25 11.7 0.0 3.7 4 0 0 4 4 4 1 AAA ATPase domain AAA_15 PF13175.6 AAS50338.2 - 8.9e-05 22.4 2.0 0.16 11.6 0.0 3.3 4 0 0 4 4 2 2 AAA ATPase domain AAA_27 PF13514.6 AAS50338.2 - 0.00023 20.8 0.0 0.21 11.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain MMS19_C PF12460.8 AAS50338.2 - 0.00029 20.1 3.4 0.24 10.5 0.2 3.3 2 1 1 3 3 3 1 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 AAS50338.2 - 0.00046 20.7 0.2 0.13 12.9 0.0 3.0 2 1 0 3 3 2 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 AAS50338.2 - 0.001 19.4 0.4 0.19 12.1 0.0 2.8 1 1 1 2 2 2 1 HEAT repeats PduV-EutP PF10662.9 AAS50338.2 - 0.0013 18.5 0.0 0.15 11.8 0.0 2.9 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_30 PF13604.6 AAS50338.2 - 0.0014 18.4 0.1 2.6 7.7 0.0 3.4 4 0 0 4 4 3 1 AAA domain DUF87 PF01935.17 AAS50338.2 - 0.0014 18.8 2.2 0.39 10.8 0.0 4.1 5 1 0 5 5 3 1 Helicase HerA, central domain AAA_24 PF13479.6 AAS50338.2 - 0.0021 17.8 0.0 1.5 8.5 0.0 3.1 3 0 0 3 3 2 1 AAA domain NACHT PF05729.12 AAS50338.2 - 0.0023 17.9 0.0 1.3 8.9 0.0 2.8 3 0 0 3 3 2 1 NACHT domain cobW PF02492.19 AAS50338.2 - 0.0031 17.1 0.2 2.9 7.4 0.0 3.6 4 0 0 4 4 2 1 CobW/HypB/UreG, nucleotide-binding domain SbcCD_C PF13558.6 AAS50338.2 - 0.0035 17.5 0.0 0.76 10.1 0.0 3.2 2 1 0 2 2 2 1 Putative exonuclease SbcCD, C subunit Rad17 PF03215.15 AAS50338.2 - 0.0036 17.3 0.0 1.7 8.5 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain HEAT_EZ PF13513.6 AAS50338.2 - 0.0056 17.2 3.8 1.2 9.7 0.1 4.3 5 0 0 5 5 2 1 HEAT-like repeat AAA_14 PF13173.6 AAS50338.2 - 0.0087 16.1 0.0 7.9 6.5 0.0 3.2 3 0 0 3 3 2 0 AAA domain ParcG PF10274.9 AAS50338.2 - 0.0097 16.0 0.7 3.8 7.6 0.0 3.0 2 1 1 3 3 3 0 Parkin co-regulated protein Roc PF08477.13 AAS50338.2 - 0.013 15.8 0.0 8.7 6.6 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cytidylate_kin PF02224.18 AAS50338.2 - 0.013 15.3 0.1 6.6 6.4 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase ATPase_2 PF01637.18 AAS50338.2 - 0.015 15.3 0.1 11 5.8 0.0 3.3 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea CLP1_P PF16575.5 AAS50338.2 - 0.018 14.8 0.5 2.2 8.1 0.0 3.2 3 0 0 3 3 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop IstB_IS21 PF01695.17 AAS50338.2 - 0.02 14.6 0.1 7.8 6.2 0.0 3.4 3 0 0 3 3 2 0 IstB-like ATP binding protein UME PF08064.13 AAS50338.2 - 0.022 14.7 0.4 0.3 11.0 0.7 2.6 2 1 1 3 3 2 0 UME (NUC010) domain Mg_chelatase PF01078.21 AAS50338.2 - 0.027 13.8 0.2 1.4 8.2 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 AAS50338.2 - 0.033 13.3 0.0 0.58 9.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein NTPase_1 PF03266.15 AAS50338.2 - 0.033 14.1 0.1 14 5.6 0.1 3.0 2 0 0 2 2 2 0 NTPase CLASP_N PF12348.8 AAS50338.2 - 0.034 13.7 0.9 0.58 9.7 0.6 2.5 2 1 0 2 2 1 0 CLASP N terminal Ploopntkinase3 PF18751.1 AAS50338.2 - 0.048 13.6 0.0 11 5.9 0.0 2.6 2 0 0 2 2 2 0 P-loop Nucleotide Kinase3 MutS_V PF00488.21 AAS50338.2 - 0.051 13.6 0.1 6.4 6.8 0.1 2.5 2 0 0 2 2 2 0 MutS domain V G-alpha PF00503.20 AAS50338.2 - 0.056 12.6 0.0 7.6 5.6 0.0 2.5 2 0 0 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 AAS50338.2 - 0.066 12.7 0.0 10 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF3437 PF11919.8 AAS50338.2 - 0.07 13.1 0.1 0.37 10.8 0.1 2.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) ATP_bind_1 PF03029.17 AAS50338.2 - 0.075 12.8 2.1 8 6.2 0.1 3.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Septin PF00735.18 AAS50338.2 - 0.079 12.2 0.3 2.6 7.3 0.0 2.6 3 0 0 3 3 2 0 Septin TsaE PF02367.17 AAS50338.2 - 0.089 12.8 0.1 7.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MukB PF04310.12 AAS50338.2 - 0.18 11.6 1.2 14 5.4 0.0 2.8 3 0 0 3 3 2 0 MukB N-terminal Zeta_toxin PF06414.12 AAS50338.2 - 0.2 10.9 1.3 21 4.3 0.0 3.2 4 0 0 4 4 4 0 Zeta toxin AAA_13 PF13166.6 AAS50338.2 - 0.22 10.1 6.8 2.6 6.6 0.0 3.8 5 0 0 5 5 3 0 AAA domain AAA_17 PF13207.6 AAS50338.2 - 0.42 11.0 4.9 9.9 6.6 0.3 4.0 4 1 0 4 4 2 0 AAA domain PLA2_B PF01735.18 AAS50339.2 - 6.3e-99 331.6 3.9 2.4e-83 280.2 0.3 2.1 2 0 0 2 2 2 2 Lysophospholipase catalytic domain Arc_PepC PF06819.11 AAS50339.2 - 0.13 12.4 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain SelP_N PF04592.14 AAS50340.1 - 0.36 10.2 9.0 0.86 9.0 9.0 1.6 1 0 0 1 1 1 0 Selenoprotein P, N terminal region EF-hand_7 PF13499.6 AAS50341.1 - 1.1e-08 35.3 0.8 3.3e-08 33.9 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AAS50341.1 - 1.2e-07 31.1 0.9 0.0032 17.3 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AAS50341.1 - 8.2e-06 25.0 1.0 0.15 11.6 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 AAS50341.1 - 0.00037 20.3 0.1 0.12 12.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 AAS50341.1 - 0.0032 16.9 0.5 0.043 13.3 0.0 2.4 2 0 0 2 2 2 1 EF hand UPF0052 PF01933.18 AAS50342.1 - 1.8e-55 188.3 0.0 2.4e-55 187.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 CLPTM1 PF05602.12 AAS50342.1 - 0.21 10.6 0.0 0.27 10.2 0.0 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) HAD PF12710.7 AAS50343.2 - 8.3e-33 114.4 0.0 1.1e-32 113.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase UMPH-1 PF05822.12 AAS50343.2 - 1.8e-06 27.7 0.0 4e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) Put_Phosphatase PF06888.12 AAS50343.2 - 3.1e-06 26.8 0.0 7e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase PF00702.26 AAS50343.2 - 0.00041 20.7 0.0 0.02 15.2 0.0 2.4 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AAS50343.2 - 0.0016 18.5 0.1 0.25 11.4 0.1 2.8 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Iso_dh PF00180.20 AAS50344.1 - 2.4e-71 240.7 0.0 2.7e-71 240.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ALS_ss_C PF10369.9 AAS50345.1 - 1.8e-16 60.1 0.0 5.7e-16 58.5 0.0 1.8 2 0 0 2 2 2 1 Small subunit of acetolactate synthase ACT PF01842.25 AAS50345.1 - 3.1e-13 49.2 0.1 5.7e-13 48.4 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT_5 PF13710.6 AAS50345.1 - 1.7e-07 31.0 0.0 3.9e-07 29.8 0.0 1.7 1 0 0 1 1 1 1 ACT domain Limkain-b1 PF11608.8 AAS50345.1 - 0.02 15.0 0.0 0.06 13.4 0.0 1.8 1 0 0 1 1 1 0 Limkain b1 KH_10 PF17905.1 AAS50345.1 - 0.028 14.9 0.0 0.063 13.7 0.0 1.6 1 0 0 1 1 1 0 GLD-3 KH domain 5 Ribosomal_L27_C PF18471.1 AAS50346.1 - 1.3e-63 214.7 4.2 1.7e-63 214.3 4.2 1.1 1 0 0 1 1 1 1 Ribosomal L27 protein C-terminal domain Ribosomal_L27 PF01016.19 AAS50346.1 - 2.1e-31 107.7 0.1 4.4e-31 106.7 0.1 1.6 1 0 0 1 1 1 1 Ribosomal L27 protein TINF2_N PF14973.6 AAS50346.1 - 0.018 15.4 0.1 0.033 14.5 0.1 1.4 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus DUF1325 PF07039.11 AAS50347.1 - 2e-38 131.4 0.0 2.6e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 SGF29 tudor-like domain Agenet PF05641.12 AAS50347.1 - 2.3e-05 24.7 0.1 0.017 15.6 0.1 2.4 2 0 0 2 2 2 2 Agenet domain Tudor_3 PF18115.1 AAS50347.1 - 4.2e-05 23.3 0.0 9.4e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 AAS50347.1 - 0.0032 17.5 0.0 0.016 15.3 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) RRM_1 PF00076.22 AAS50348.1 - 4.2e-54 180.3 0.0 1.6e-19 69.5 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_9 PF18444.1 AAS50348.1 - 0.00018 21.3 0.0 0.55 10.1 0.0 3.2 3 0 0 3 3 3 2 RNA recognition motif RRM_Rrp7 PF17799.1 AAS50348.1 - 0.0012 18.7 0.0 5.7 6.7 0.0 3.1 3 0 0 3 3 3 2 Rrp7 RRM-like N-terminal domain DUF2015 PF09435.10 AAS50349.1 - 1.4e-27 95.8 0.0 1.6e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2015) DUF3507 PF12015.8 AAS50350.1 - 1.3e-66 223.8 0.0 2.4e-66 222.9 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Dcc1 PF09724.9 AAS50351.1 - 6.5e-74 249.2 0.0 7.4e-74 249.0 0.0 1.0 1 0 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 Mito_carr PF00153.27 AAS50352.1 - 6.4e-52 173.5 4.9 1.2e-19 70.0 0.1 4.1 3 1 1 4 4 4 4 Mitochondrial carrier protein Serine_protease PF18405.1 AAS50352.1 - 0.0019 17.4 1.5 0.026 13.7 1.5 2.8 1 1 0 1 1 1 1 Gammaproteobacterial serine protease COG5 PF10392.9 AAS50352.1 - 0.026 14.7 0.4 0.041 14.0 0.4 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 CALCOCO1 PF07888.11 AAS50352.1 - 0.03 13.2 0.1 0.042 12.7 0.1 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Aminotran_5 PF00266.19 AAS50353.1 - 1.1e-101 340.5 0.0 1.3e-101 340.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AAS50353.1 - 1.8e-09 37.3 0.0 2.5e-09 36.9 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AAS50353.1 - 1.4e-08 34.5 0.0 3.3e-08 33.2 0.0 1.5 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 AAS50353.1 - 0.0014 17.4 0.0 0.0022 16.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain Cys_Met_Meta_PP PF01053.20 AAS50353.1 - 0.035 12.6 0.1 0.052 12.1 0.1 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme 4_1_CTD PF05902.13 AAS50353.1 - 0.16 12.1 0.7 0.45 10.6 0.3 1.9 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) Iso_dh PF00180.20 AAS50354.1 - 1.3e-124 415.9 0.0 1.4e-124 415.7 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Ribosomal_L30 PF00327.20 AAS50355.1 - 1.1e-10 41.2 0.2 2.3e-10 40.2 0.2 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_L30_N PF08079.12 AAS50355.1 - 1.8 8.8 23.4 0.19 12.0 18.4 2.0 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain RFX_DNA_binding PF02257.15 AAS50356.1 - 1.7e-30 105.4 0.0 8.7e-30 103.2 0.0 2.2 2 0 0 2 2 2 1 RFX DNA-binding domain Pox_D5 PF03288.16 AAS50356.1 - 0.0027 18.2 0.0 0.01 16.3 0.0 2.0 1 0 0 1 1 1 1 Poxvirus D5 protein-like Pyrophosphatase PF00719.19 AAS50356.1 - 1.1 9.0 7.2 0.43 10.4 0.2 2.8 2 1 1 3 3 3 0 Inorganic pyrophosphatase WD40 PF00400.32 AAS50357.1 - 2e-40 136.0 18.5 6.2e-11 42.7 0.1 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50357.1 - 7.3e-12 45.4 3.7 0.0078 16.5 0.0 5.1 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS50357.1 - 3e-10 39.4 11.8 0.0026 16.5 0.2 4.9 1 1 1 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AAS50357.1 - 9.6e-07 28.1 1.8 0.0053 15.8 0.1 4.3 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 AAS50357.1 - 1.2e-05 24.3 1.6 0.0012 17.7 0.1 3.4 1 1 2 4 4 4 2 Nup133 N terminal like Frtz PF11768.8 AAS50357.1 - 0.0002 19.9 0.0 0.00099 17.5 0.0 2.0 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF1513 PF07433.11 AAS50357.1 - 0.00085 18.5 0.3 1.4 7.9 0.0 3.0 1 1 2 4 4 4 2 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 AAS50357.1 - 0.013 14.4 0.1 0.013 14.4 0.1 2.6 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Hira PF07569.11 AAS50357.1 - 0.015 15.1 2.4 0.46 10.2 0.2 3.5 2 1 1 3 3 3 0 TUP1-like enhancer of split WD40_like PF17005.5 AAS50357.1 - 0.03 13.7 0.0 0.67 9.2 0.0 2.5 1 1 2 3 3 3 0 WD40-like domain DnaJ_C PF01556.18 AAS50358.1 - 1.3e-36 125.9 0.2 1.6e-36 125.6 0.2 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AAS50358.1 - 4.9e-23 81.0 0.2 7.6e-23 80.4 0.2 1.3 1 0 0 1 1 1 1 DnaJ domain Malate_DH PF12434.8 AAS50358.1 - 0.51 10.4 1.6 2.4 8.3 1.6 2.2 1 1 0 1 1 1 0 Malate dehydrogenase enzyme DKCLD PF08068.12 AAS50359.1 - 3.6e-32 110.2 0.2 3.5e-31 107.0 0.3 2.2 2 0 0 2 2 2 1 DKCLD (NUC011) domain TruB_C_2 PF16198.5 AAS50359.1 - 2.9e-23 81.8 0.4 5.7e-23 80.8 0.4 1.5 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 AAS50359.1 - 2.4e-20 72.3 1.4 4.8e-20 71.3 1.4 1.6 1 0 0 1 1 1 1 PUA domain TruB_N PF01509.18 AAS50359.1 - 8.1e-20 71.7 9.0 5.4e-19 69.0 0.0 3.9 2 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) UPF0113 PF03657.13 AAS50359.1 - 0.022 15.0 0.0 0.055 13.7 0.0 1.7 1 0 0 1 1 1 0 UPF0113 PUA domain GAGA_bind PF06217.12 AAS50359.1 - 3.8 7.7 19.3 5.2 7.3 19.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family RR_TM4-6 PF06459.12 AAS50359.1 - 6.4 6.5 34.1 8.8 6.1 34.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 AAS50359.1 - 8.5 5.3 33.1 11 4.8 33.1 1.1 1 0 0 1 1 1 0 Paf1 UEV PF05743.13 AAS50360.1 - 7.4e-30 103.3 0.0 2.3e-29 101.7 0.0 1.8 2 0 0 2 2 2 1 UEV domain Vps23_core PF09454.10 AAS50360.1 - 1.3e-21 76.3 0.3 5.2e-21 74.4 0.1 2.1 2 0 0 2 2 2 1 Vps23 core domain Tmemb_cc2 PF10267.9 AAS50360.1 - 0.039 13.1 0.8 0.054 12.6 0.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Sds3 PF08598.11 AAS50360.1 - 0.11 12.5 2.3 0.092 12.7 0.8 1.6 1 1 0 1 1 1 0 Sds3-like ATP_synt_H PF05493.13 AAS50361.1 - 4.4e-19 68.7 4.3 5.3e-19 68.4 4.3 1.1 1 0 0 1 1 1 1 ATP synthase subunit H MFS_2 PF13347.6 AAS50361.1 - 0.0098 14.5 0.7 0.01 14.4 0.7 1.0 1 0 0 1 1 1 1 MFS/sugar transport protein AzlD PF05437.12 AAS50361.1 - 0.032 14.4 3.9 0.042 14.0 0.1 2.1 1 1 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) DUF4131 PF13567.6 AAS50361.1 - 0.1 12.2 0.5 0.12 12.0 0.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DHHC PF01529.20 AAS50361.1 - 0.53 10.4 3.1 0.6 10.2 3.1 1.1 1 0 0 1 1 1 0 DHHC palmitoyltransferase CPP1-like PF11833.8 AAS50361.1 - 1.1 8.9 4.4 1.3 8.6 4.4 1.0 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like PLDc_2 PF13091.6 AAS50363.1 - 5.4e-16 58.7 0.0 3.6e-07 30.1 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 AAS50363.1 - 4.8e-12 45.5 1.3 3.7e-06 26.9 0.1 2.5 2 0 0 2 2 2 2 Phospholipase D Active site motif Rer1 PF03248.13 AAS50364.1 - 9.9e-73 243.5 10.1 1.1e-72 243.3 10.1 1.0 1 0 0 1 1 1 1 Rer1 family DUF2208 PF09973.9 AAS50364.1 - 3.7 7.1 8.8 0.54 9.8 1.3 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) eRF1_2 PF03464.15 AAS50365.1 - 1.3e-27 96.7 0.2 2.3e-27 95.9 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AAS50365.1 - 8.9e-26 90.6 0.0 1.7e-24 86.5 0.0 2.5 2 1 0 2 2 2 1 eRF1 domain 3 eRF1_1 PF03463.15 AAS50365.1 - 8.7e-19 67.8 0.1 1.3e-18 67.2 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 SNF2_N PF00176.23 AAS50365.1 - 0.0059 15.4 0.2 0.0097 14.7 0.2 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Septin PF00735.18 AAS50366.1 - 4.1e-106 354.4 2.0 4.8e-106 354.1 2.0 1.0 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AAS50366.1 - 2.3e-10 40.6 0.1 3.6e-10 39.9 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS50366.1 - 2.7e-08 33.6 0.7 3.7e-06 26.6 0.2 2.3 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AAS50366.1 - 1.4e-06 27.8 0.6 4.2e-06 26.2 0.6 1.8 1 1 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 AAS50366.1 - 2.4e-06 27.6 0.4 1.2e-05 25.3 0.1 2.0 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 AAS50366.1 - 2.9e-05 24.2 1.5 0.031 14.3 0.6 2.4 1 1 1 2 2 2 2 Dynamin family AAA_16 PF13191.6 AAS50366.1 - 0.0011 19.4 0.1 0.0015 18.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS50366.1 - 0.0027 18.0 0.1 0.0061 16.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AAS50366.1 - 0.0029 18.1 0.9 0.0067 16.9 1.0 1.7 1 1 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 AAS50366.1 - 0.0058 15.8 0.2 0.01 15.0 0.2 1.5 1 1 0 1 1 1 1 NB-ARC domain AAA_33 PF13671.6 AAS50366.1 - 0.0086 16.2 0.5 0.11 12.6 1.3 2.5 2 1 0 2 2 2 1 AAA domain IIGP PF05049.13 AAS50366.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_29 PF13555.6 AAS50366.1 - 0.017 14.9 0.0 0.041 13.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 AAS50366.1 - 0.02 14.3 0.1 0.036 13.4 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Roc PF08477.13 AAS50366.1 - 0.027 14.7 0.0 0.057 13.6 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 AAS50366.1 - 0.029 13.9 0.2 0.07 12.6 0.1 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 AAS50366.1 - 0.042 13.6 0.7 0.21 11.3 0.7 2.2 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AAS50366.1 - 0.052 13.1 0.0 0.083 12.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AAS50366.1 - 0.066 13.7 0.2 0.11 12.9 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AAS50366.1 - 0.087 12.9 0.0 0.28 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AAS50366.1 - 0.097 13.1 0.0 0.25 11.8 0.0 1.7 2 0 0 2 2 1 0 RNA helicase PduV-EutP PF10662.9 AAS50366.1 - 0.098 12.4 0.2 1.1 9.0 0.1 2.6 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Ribosomal_L32p PF01783.23 AAS50367.2 - 2e-11 44.0 3.7 4.1e-11 43.0 3.7 1.5 1 0 0 1 1 1 1 Ribosomal L32p protein family zf-ribbon_3 PF13248.6 AAS50367.2 - 0.021 14.2 1.4 0.042 13.3 1.4 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 AAS50367.2 - 0.05 13.3 0.3 0.099 12.4 0.3 1.4 1 0 0 1 1 1 0 Rubredoxin metal binding domain RecR PF02132.15 AAS50367.2 - 0.12 12.0 0.3 0.21 11.2 0.3 1.4 1 0 0 1 1 1 0 RecR protein Cupin_8 PF13621.6 AAS50368.1 - 9.9e-12 45.1 0.0 2.6e-11 43.7 0.0 1.6 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AAS50368.1 - 5.9e-09 36.4 0.1 1.7e-08 34.9 0.1 1.9 1 1 0 1 1 1 1 JmjC domain, hydroxylase F-box-like PF12937.7 AAS50368.1 - 1.9e-06 27.6 0.0 5.4e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 F-box-like Elongin_A PF06881.11 AAS50368.1 - 0.00018 22.0 0.1 0.00086 19.8 0.0 2.2 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A GPI PF06560.11 AAS50368.1 - 0.063 12.5 0.2 0.22 10.8 0.1 1.8 2 0 0 2 2 2 0 Glucose-6-phosphate isomerase (GPI) Cupin_2 PF07883.11 AAS50368.1 - 0.17 11.6 0.0 0.54 10.0 0.0 1.7 2 0 0 2 2 2 0 Cupin domain Citrate_synt PF00285.21 AAS50369.1 - 2.1e-99 333.0 0.0 2.5e-99 332.8 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain SH3BGR PF04908.15 AAS50371.2 - 0.0017 18.5 0.0 0.005 17.0 0.0 1.9 1 0 0 1 1 1 1 SH3-binding, glutamic acid-rich protein Glycogen_syn PF05693.13 AAS50373.2 - 0 1105.5 0.0 0 1105.3 0.0 1.0 1 0 0 1 1 1 1 Glycogen synthase Glycos_transf_1 PF00534.20 AAS50373.2 - 3.3e-08 33.3 0.0 1.5e-05 24.6 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AAS50373.2 - 8.7e-07 29.4 0.0 0.0011 19.4 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 AAS50373.2 - 0.00012 21.8 0.4 0.00025 20.8 0.4 1.5 1 0 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_4 PF13579.6 AAS50373.2 - 0.00013 22.4 0.1 0.00033 21.1 0.1 1.8 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.6 AAS50373.2 - 0.00068 19.7 0.7 0.0022 18.0 0.2 2.0 2 0 0 2 2 2 1 Glycosyltransferase Family 4 CDI PF02234.19 AAS50373.2 - 0.13 12.5 0.3 0.32 11.2 0.3 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor Pkinase PF00069.25 AAS50374.1 - 3.8e-72 242.8 0.0 6.1e-72 242.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50374.1 - 2.8e-42 144.8 0.0 4.3e-42 144.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS50374.1 - 0.00017 21.0 0.0 0.00098 18.5 0.0 2.1 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AAS50374.1 - 0.00021 20.2 1.0 0.00054 18.9 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AAS50374.1 - 0.012 15.0 0.0 0.022 14.1 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family bZIP_2 PF07716.15 AAS50375.1 - 6.3e-07 29.4 8.3 6.3e-07 29.4 8.3 3.4 2 1 1 3 3 3 1 Basic region leucine zipper bZIP_1 PF00170.21 AAS50375.1 - 0.0064 16.6 10.2 0.0064 16.6 10.2 1.9 2 1 0 2 2 2 1 bZIP transcription factor SlyX PF04102.12 AAS50375.1 - 0.063 13.9 0.6 0.22 12.1 0.6 2.0 1 0 0 1 1 1 0 SlyX PRP38 PF03371.15 AAS50375.1 - 0.087 12.7 0.3 0.14 12.0 0.3 1.3 1 0 0 1 1 1 0 PRP38 family Proteasome PF00227.26 AAS50377.1 - 1.5e-56 190.9 0.0 1.9e-56 190.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS50377.1 - 1.2e-12 47.2 0.2 4.2e-12 45.5 0.0 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature TGBp3 PF02495.17 AAS50377.1 - 0.14 11.9 0.2 0.28 10.9 0.2 1.5 1 0 0 1 1 1 0 Triple gene block 3 TOM13 PF08219.11 AAS50378.2 - 4.3e-22 77.9 0.0 5.8e-22 77.5 0.0 1.2 1 0 0 1 1 1 1 Outer membrane protein TOM13 Rpr2 PF04032.16 AAS50379.1 - 2.5e-17 62.9 0.2 3.4e-17 62.5 0.2 1.2 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF3488 PF11992.8 AAS50380.1 - 2 7.3 10.7 0.12 11.3 5.5 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3488) LETM1 PF07766.13 AAS50381.1 - 1.4e-100 336.0 3.4 2.1e-100 335.5 3.4 1.2 1 0 0 1 1 1 1 LETM1-like protein YycC PF14174.6 AAS50381.1 - 0.0013 18.5 0.1 0.0046 16.7 0.1 1.9 1 0 0 1 1 1 1 YycC-like protein Glyco_hydro_5_C PF18564.1 AAS50382.1 - 6.2e-14 52.3 0.1 1.1e-13 51.5 0.1 1.5 1 0 0 1 1 1 1 Glycoside hydrolase family 5 C-terminal domain Cellulase PF00150.18 AAS50382.1 - 7.7e-12 45.2 0.0 4e-09 36.3 0.0 2.7 2 1 0 2 2 2 2 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_35 PF01301.19 AAS50382.1 - 0.013 15.2 0.1 0.022 14.4 0.1 1.3 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 DNA_primase_S PF01896.19 AAS50383.1 - 1.5e-65 220.5 0.3 2e-65 220.1 0.3 1.2 1 0 0 1 1 1 1 DNA primase small subunit GlutR_dimer PF00745.20 AAS50383.1 - 0.15 12.5 0.3 1.3 9.5 0.0 2.2 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Proteasome PF00227.26 AAS50384.1 - 3.1e-41 141.0 0.0 3.5e-41 140.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit HA2 PF04408.23 AAS50385.2 - 1.5e-24 86.3 0.9 2.9e-24 85.4 0.0 2.0 2 0 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AAS50385.2 - 2.4e-18 66.3 0.0 5.2e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold S1 PF00575.23 AAS50385.2 - 9.4e-14 51.5 0.0 1.8e-13 50.6 0.0 1.5 1 0 0 1 1 1 1 S1 RNA binding domain Helicase_C PF00271.31 AAS50385.2 - 9.8e-14 51.6 0.1 5.9e-13 49.1 0.0 2.4 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AAS50385.2 - 1.1e-05 25.3 0.4 3.2e-05 23.8 0.4 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS50385.2 - 5.4e-05 23.5 1.2 0.00017 21.9 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS50385.2 - 0.00093 19.0 0.1 0.0021 17.8 0.1 1.5 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AAS50385.2 - 0.0032 16.6 0.1 0.0096 15.0 0.0 1.9 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_19 PF13245.6 AAS50385.2 - 0.017 15.4 0.1 0.079 13.3 0.1 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 AAS50385.2 - 0.018 15.5 3.2 0.72 10.4 0.0 3.5 3 0 0 3 3 3 0 ABC transporter PWI PF01480.17 AAS50385.2 - 0.025 14.9 1.8 1.4 9.3 0.5 2.8 2 0 0 2 2 2 0 PWI domain AAA PF00004.29 AAS50385.2 - 0.047 14.1 0.0 0.19 12.1 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 AAS50385.2 - 0.051 13.6 0.1 0.99 9.4 0.1 2.8 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 AAS50385.2 - 0.058 13.0 0.1 0.13 11.9 0.1 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain PhoH PF02562.16 AAS50385.2 - 0.14 11.6 0.5 0.44 10.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein NAD_binding_8 PF13450.6 AAS50386.2 - 1.2e-09 38.3 0.0 3.2e-09 36.9 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AAS50386.2 - 8.1e-05 22.0 0.0 0.0023 17.2 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AAS50386.2 - 0.00013 21.6 0.0 0.00051 19.7 0.0 1.9 2 1 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 AAS50386.2 - 0.00042 19.6 0.1 0.0008 18.7 0.1 1.4 1 0 0 1 1 1 1 Thi4 family Pyr_redox PF00070.27 AAS50386.2 - 0.0022 18.5 0.0 0.034 14.7 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AAS50386.2 - 0.055 12.5 0.0 0.082 12.0 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 AAS50386.2 - 0.11 12.5 0.0 9.7 6.2 0.0 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding Mqo PF06039.15 AAS50386.2 - 0.14 10.7 0.0 0.31 9.6 0.0 1.5 2 0 0 2 2 2 0 Malate:quinone oxidoreductase (Mqo) RRM_5 PF13893.6 AAS50387.1 - 4.1e-08 32.9 0.0 4.7e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 AAS50387.1 - 6e-07 29.2 0.0 1e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS50387.1 - 0.0096 15.8 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 Occluded RNA-recognition motif GCR1_C PF12550.8 AAS50388.1 - 1.4e-14 54.2 1.9 1.4e-14 54.2 1.9 1.9 2 0 0 2 2 2 1 Transcriptional activator of glycolytic enzymes SlyX PF04102.12 AAS50388.1 - 0.024 15.3 0.7 0.11 13.2 0.2 2.2 2 0 0 2 2 2 0 SlyX Rab_bind PF16704.5 AAS50388.1 - 0.1 12.6 1.0 0.29 11.2 0.9 1.8 2 0 0 2 2 2 0 Rab binding domain EB1 PF03271.17 AAS50389.1 - 1.3e-15 57.3 0.3 2.4e-15 56.5 0.3 1.4 1 0 0 1 1 1 1 EB1-like C-terminal motif CH PF00307.31 AAS50389.1 - 7.1e-05 22.9 0.0 0.00015 21.9 0.0 1.6 1 0 0 1 1 1 1 Calponin homology (CH) domain SlyX PF04102.12 AAS50389.1 - 0.019 15.6 0.7 0.048 14.3 0.7 1.6 1 0 0 1 1 1 0 SlyX CH_2 PF06294.11 AAS50389.1 - 0.14 12.3 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 CH-like domain in sperm protein Peptidase_M41 PF01434.18 AAS50390.2 - 1.3e-67 227.4 0.0 2.1e-67 226.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AAS50390.2 - 3.5e-43 147.2 0.0 7.2e-43 146.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS50390.2 - 1.2e-10 41.0 0.2 5.5e-10 38.9 0.1 2.1 2 0 0 2 2 2 1 AAA+ lid domain FtsH_ext PF06480.15 AAS50390.2 - 3.8e-05 24.0 0.0 8.6e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular TIP49 PF06068.13 AAS50390.2 - 0.0057 15.9 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 AAS50390.2 - 0.0063 16.5 0.1 0.035 14.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS50390.2 - 0.0071 16.7 0.4 0.037 14.4 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AAS50390.2 - 0.0092 15.7 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 AAS50390.2 - 0.0097 15.6 0.0 0.027 14.2 0.0 1.7 1 1 0 1 1 1 1 IstB-like ATP binding protein AAA_22 PF13401.6 AAS50390.2 - 0.017 15.4 0.1 0.63 10.3 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 AAS50390.2 - 0.078 13.1 0.1 0.42 10.7 0.0 2.2 2 1 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_17 PF13207.6 AAS50390.2 - 0.099 13.1 0.1 0.24 11.8 0.1 1.7 1 0 0 1 1 1 0 AAA domain HMG_box PF00505.19 AAS50391.2 - 1.6e-13 50.9 5.5 2.3e-12 47.1 5.5 2.3 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS50391.2 - 1.7e-05 25.3 2.9 3.8e-05 24.2 2.9 1.6 1 1 0 1 1 1 1 HMG-box domain Ribosomal_S5_C PF03719.15 AAS50392.2 - 7e-24 83.1 0.0 1.8e-23 81.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 AAS50392.2 - 1.2e-23 82.9 0.2 2.1e-23 82.1 0.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain SURF1 PF02104.15 AAS50393.1 - 8.8e-46 156.3 1.4 1.3e-45 155.8 1.4 1.2 1 0 0 1 1 1 1 SURF1 family DUF5634 PF18681.1 AAS50393.1 - 0.13 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5634) DASH_Dam1 PF08653.10 AAS50394.2 - 9.2e-26 89.4 0.6 1.7e-25 88.5 0.6 1.5 1 0 0 1 1 1 1 DASH complex subunit Dam1 IFP_35_N PF07334.13 AAS50394.2 - 0.12 12.5 0.4 0.3 11.2 0.4 1.7 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Ctr PF04145.15 AAS50395.1 - 3.2e-18 66.7 1.3 5.9e-18 65.9 0.3 1.8 2 0 0 2 2 2 1 Ctr copper transporter family LPG_synthase_TM PF03706.13 AAS50395.1 - 0.0059 16.2 1.3 0.0078 15.8 1.3 1.1 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region SH2_2 PF14633.6 AAS50396.2 - 4.7e-69 232.1 2.3 1.5e-68 230.4 2.3 2.0 1 0 0 1 1 1 1 SH2 domain YqgF PF14639.6 AAS50396.2 - 1e-59 200.7 0.7 7.2e-59 197.9 0.1 2.5 2 0 0 2 2 2 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 AAS50396.2 - 5.2e-43 145.6 0.5 2.2e-42 143.7 0.1 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix motif HTH_44 PF14641.6 AAS50396.2 - 1.3e-32 112.6 1.2 1.3e-32 112.6 1.2 2.5 2 0 0 2 2 2 1 Helix-turn-helix DNA-binding domain of SPT6 SPT6_acidic PF14632.6 AAS50396.2 - 1.4e-19 70.5 19.0 1.4e-19 70.5 19.0 5.6 3 1 0 4 4 1 1 Acidic N-terminal SPT6 SH2 PF00017.24 AAS50396.2 - 1.8e-11 44.0 0.0 5.5e-11 42.4 0.0 1.9 1 0 0 1 1 1 1 SH2 domain HHH_9 PF17674.1 AAS50396.2 - 0.00027 21.8 6.5 0.00058 20.7 0.1 4.5 3 0 0 3 3 3 1 HHH domain Formyl_trans_N PF00551.19 AAS50396.2 - 0.031 14.0 0.1 0.079 12.7 0.1 1.6 1 0 0 1 1 1 0 Formyl transferase Tex_YqgF PF16921.5 AAS50396.2 - 0.041 14.3 0.0 0.096 13.1 0.0 1.6 1 0 0 1 1 1 0 Tex protein YqgF-like domain RGS PF00615.19 AAS50396.2 - 0.18 12.1 10.4 0.033 14.5 2.3 3.6 3 0 0 3 3 3 0 Regulator of G protein signaling domain EloA-BP1 PF15870.5 AAS50396.2 - 0.41 10.9 3.7 0.46 10.7 0.1 2.6 2 0 0 2 2 2 0 ElonginA binding-protein 1 LETM1 PF07766.13 AAS50397.2 - 7e-97 323.9 5.1 7e-97 323.9 5.1 1.5 2 0 0 2 2 2 1 LETM1-like protein LexA_DNA_bind PF01726.16 AAS50397.2 - 0.011 15.5 0.0 0.029 14.2 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain Aldo_ket_red PF00248.21 AAS50398.1 - 5.5e-45 153.8 0.0 6.3e-45 153.6 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family tRNA-synt_1 PF00133.22 AAS50399.1 - 1.4e-233 776.6 0.0 2e-232 772.8 0.0 2.3 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AAS50399.1 - 1.4e-32 112.7 1.2 1.4e-32 112.7 1.2 2.4 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AAS50399.1 - 5.1e-14 51.8 0.1 8.1e-08 31.4 0.0 4.2 4 1 0 4 4 4 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 AAS50399.1 - 1.1e-08 34.8 14.0 3.1e-07 30.1 0.0 4.1 3 1 1 4 4 4 2 Leucyl-tRNA synthetase, Domain 2 Lzipper-MIP1 PF14389.6 AAS50399.1 - 0.00054 20.2 1.1 0.0018 18.6 1.1 1.8 1 0 0 1 1 1 1 Leucine-zipper of ternary complex factor MIP1 Val_tRNA-synt_C PF10458.9 AAS50399.1 - 0.0022 18.3 5.5 0.0022 18.3 5.5 3.4 3 0 0 3 3 3 1 Valyl tRNA synthetase tRNA binding arm tRNA-synt_1e PF01406.19 AAS50399.1 - 0.06 12.7 2.6 2.9 7.1 0.0 3.2 3 0 0 3 3 3 0 tRNA synthetases class I (C) catalytic domain Adenine_glyco PF03352.13 AAS50399.1 - 0.07 12.9 7.5 0.058 13.2 3.2 2.3 2 0 0 2 2 2 0 Methyladenine glycosylase AAA_23 PF13476.6 AAS50399.1 - 0.9 10.0 18.0 0.13 12.7 0.8 2.7 2 0 0 2 2 2 0 AAA domain tRNA-synt_1c PF00749.21 AAS50399.1 - 3.3 6.5 7.8 0.94 8.3 0.0 2.5 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), catalytic domain DUF3450 PF11932.8 AAS50399.1 - 6.5 6.0 17.0 0.32 10.3 1.8 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) RNase_PH PF01138.21 AAS50400.2 - 7.8e-16 58.8 0.0 1.4e-15 57.9 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AAS50400.2 - 0.0025 17.8 0.1 0.0044 17.0 0.1 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Mito_carr PF00153.27 AAS50401.1 - 6.3e-54 179.9 2.0 2.5e-21 75.4 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein CDP-OH_P_transf PF01066.21 AAS50402.1 - 3e-13 50.3 0.5 3e-13 50.3 0.5 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase AA_permease PF00324.21 AAS50403.2 - 4.2e-122 408.2 31.8 4.7e-122 408.0 31.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS50403.2 - 3.9e-21 75.4 31.9 4.7e-21 75.1 31.9 1.0 1 0 0 1 1 1 1 Amino acid permease DUF1712 PF08217.11 AAS50405.1 - 9.9e-220 731.1 0.0 1.1e-219 730.9 0.0 1.0 1 0 0 1 1 1 1 Fungal domain of unknown function (DUF1712) SRP54 PF00448.22 AAS50406.2 - 3.9e-77 258.3 1.0 3.9e-77 258.3 1.0 2.0 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 AAS50406.2 - 5.9e-28 97.4 8.1 5.9e-28 97.4 8.1 3.6 3 1 0 3 3 2 1 Signal peptide binding domain SRP54_N PF02881.19 AAS50406.2 - 4.9e-13 49.1 1.6 1.2e-12 47.8 1.6 1.7 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain AAA_33 PF13671.6 AAS50406.2 - 1.1e-05 25.6 0.0 3.7e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 AAS50406.2 - 2.6e-05 23.9 1.6 0.00038 20.1 1.3 2.8 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AAS50406.2 - 0.00023 21.2 0.0 0.00077 19.5 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_30 PF13604.6 AAS50406.2 - 0.00058 19.6 0.2 0.0025 17.6 0.2 2.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AAS50406.2 - 0.0025 18.2 1.8 0.005 17.3 0.1 2.4 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 AAS50406.2 - 0.0043 16.1 0.1 0.011 14.7 0.1 1.8 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 AAS50406.2 - 0.0057 16.6 0.1 0.017 15.0 0.0 1.9 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_16 PF13191.6 AAS50406.2 - 0.0058 17.0 0.0 0.013 15.9 0.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain SRPRB PF09439.10 AAS50406.2 - 0.011 15.2 0.5 5.3 6.4 0.1 3.3 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit VirE PF05272.11 AAS50406.2 - 0.012 15.4 0.1 0.03 14.0 0.1 1.7 1 0 0 1 1 1 0 Virulence-associated protein E APS_kinase PF01583.20 AAS50406.2 - 0.014 15.3 0.0 0.04 13.8 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA PF00004.29 AAS50406.2 - 0.018 15.5 0.8 0.44 11.0 0.7 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 AAS50406.2 - 0.023 14.6 0.0 0.067 13.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 AAS50406.2 - 0.028 14.5 0.2 0.14 12.2 0.1 2.3 3 1 0 3 3 1 0 50S ribosome-binding GTPase Arf PF00025.21 AAS50406.2 - 0.029 13.8 0.1 0.43 10.0 0.0 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family MipZ PF09140.11 AAS50406.2 - 0.066 12.5 0.4 1.5 8.1 0.4 2.5 1 1 0 1 1 1 0 ATPase MipZ Zeta_toxin PF06414.12 AAS50406.2 - 0.07 12.4 0.1 0.26 10.5 0.1 2.1 1 1 0 1 1 1 0 Zeta toxin ArsA_ATPase PF02374.15 AAS50406.2 - 0.078 12.1 13.5 0.38 9.9 0.2 4.1 4 0 0 4 4 4 0 Anion-transporting ATPase AAA_28 PF13521.6 AAS50406.2 - 0.098 12.9 0.3 1.1 9.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AAS50406.2 - 0.11 13.0 0.1 0.35 11.4 0.0 2.0 2 1 0 2 2 1 0 AAA domain ApbA_C PF08546.11 AAS50406.2 - 0.38 11.0 2.9 7.9 6.7 0.0 3.2 3 0 0 3 3 3 0 Ketopantoate reductase PanE/ApbA C terminal SHE3 PF17078.5 AAS50407.1 - 3.8e-89 298.3 26.5 4.7e-89 298.0 26.5 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 TMF_DNA_bd PF12329.8 AAS50407.1 - 0.00054 19.9 6.3 0.00054 19.9 6.3 3.2 2 2 0 2 2 2 1 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 AAS50407.1 - 0.0018 17.2 19.4 0.0028 16.6 19.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein CEP209_CC5 PF16574.5 AAS50407.1 - 0.0025 18.0 5.7 0.0025 18.0 5.7 2.3 1 1 0 2 2 2 1 Coiled-coil region of centrosome protein CE290 DUF1664 PF07889.12 AAS50407.1 - 0.0027 17.7 10.2 0.08 13.0 2.4 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 AAS50407.1 - 0.042 14.0 1.4 0.042 14.0 1.4 4.8 3 1 2 5 5 5 0 bZIP transcription factor Filament PF00038.21 AAS50407.1 - 0.12 12.0 24.0 0.39 10.3 7.3 2.4 1 1 1 2 2 2 0 Intermediate filament protein Prp19 PF08606.11 AAS50407.1 - 0.31 11.1 4.2 4.5 7.3 1.1 2.6 2 0 0 2 2 2 0 Prp19/Pso4-like Jnk-SapK_ap_N PF09744.9 AAS50407.1 - 0.45 10.7 27.2 0.51 10.6 13.1 2.6 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Aconitase_C PF00694.19 AAS50407.1 - 0.61 10.4 3.7 1 9.7 0.5 2.5 2 1 1 3 3 3 0 Aconitase C-terminal domain ZapB PF06005.12 AAS50407.1 - 0.65 10.5 27.1 0.34 11.4 8.6 3.7 1 1 2 3 3 3 0 Cell division protein ZapB DUF3450 PF11932.8 AAS50407.1 - 0.72 9.1 22.8 0.034 13.5 7.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Formin_GBD_N PF18382.1 AAS50407.1 - 0.85 10.1 5.3 12 6.4 0.1 2.9 3 0 0 3 3 3 0 Formin N-terminal GTPase-binding domain Golgin_A5 PF09787.9 AAS50407.1 - 1.1 8.7 22.0 0.3 10.5 17.3 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 5 TMPIT PF07851.13 AAS50407.1 - 1.2 8.4 17.7 2.9 7.0 5.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein GAS PF13851.6 AAS50407.1 - 1.4 8.2 26.7 0.33 10.3 21.6 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FAM184 PF15665.5 AAS50407.1 - 1.6 8.5 24.3 16 5.2 24.6 2.3 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B HMMR_N PF15905.5 AAS50407.1 - 1.6 8.2 26.2 0.86 9.0 22.6 2.2 2 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal APG6_N PF17675.1 AAS50407.1 - 2 8.9 29.6 15 6.1 16.7 2.7 1 1 1 2 2 2 0 Apg6 coiled-coil region FUSC PF04632.12 AAS50407.1 - 2.1 6.8 4.3 3.7 6.0 4.3 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family SOAR PF16533.5 AAS50407.1 - 2.5 8.1 12.5 0.27 11.2 4.1 2.5 2 0 0 2 2 2 0 STIM1 Orai1-activating region T3SSipB PF16535.5 AAS50407.1 - 3.2 8.2 10.0 2.7 8.4 6.6 2.1 1 1 1 2 2 2 0 Type III cell invasion protein SipB TPR_MLP1_2 PF07926.12 AAS50407.1 - 3.7 7.6 25.8 5.9 7.0 22.7 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein VPS11_C PF12451.8 AAS50407.1 - 4.5 7.6 9.5 7.8 6.8 0.2 3.5 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal HrpB7 PF09486.10 AAS50407.1 - 4.6 7.6 15.5 13 6.2 11.5 2.8 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) Csm1_N PF18504.1 AAS50407.1 - 4.8 7.6 22.6 1.5 9.2 4.2 3.9 1 1 2 4 4 4 0 Csm1 N-terminal domain DUF948 PF06103.11 AAS50407.1 - 4.8 7.5 9.3 6.9 7.0 0.7 3.2 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMCO5 PF14992.6 AAS50407.1 - 5.1 6.6 21.4 3.4 7.2 18.8 1.7 1 1 1 2 2 2 0 TMCO5 family Val_tRNA-synt_C PF10458.9 AAS50407.1 - 5.1 7.4 7.1 4.2 7.7 1.0 3.5 4 1 0 4 4 2 0 Valyl tRNA synthetase tRNA binding arm Glyco_transf_22 PF03901.17 AAS50408.1 - 3.7e-32 112.1 15.7 5.1e-32 111.6 15.7 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family cobW PF02492.19 AAS50409.1 - 1.3e-44 151.9 0.1 1.8e-44 151.4 0.1 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 AAS50409.1 - 0.00061 19.7 0.1 0.0013 18.6 0.1 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain GTP_EFTU PF00009.27 AAS50409.1 - 0.0009 18.8 0.2 0.037 13.6 0.4 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 AAS50409.1 - 0.002 18.7 0.1 0.012 16.2 0.0 2.1 2 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AAS50409.1 - 0.0029 17.3 0.5 0.011 15.4 0.0 2.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_16 PF13191.6 AAS50409.1 - 0.0031 17.9 0.0 0.0091 16.4 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 AAS50409.1 - 0.0042 17.6 0.1 0.012 16.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AAS50409.1 - 0.018 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 AAS50409.1 - 0.056 13.4 0.8 0.73 9.7 0.1 2.2 2 0 0 2 2 2 0 RsgA GTPase MMR_HSR1 PF01926.23 AAS50409.1 - 0.098 12.7 0.0 0.23 11.5 0.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.6 AAS50409.1 - 0.13 12.5 0.0 0.29 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pro_isomerase PF00160.21 AAS50410.1 - 1.6e-27 96.7 0.0 2.6e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Lipase_3 PF01764.25 AAS50411.1 - 6.9e-09 35.7 0.0 1.3e-08 34.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_1 PF00561.20 AAS50411.1 - 0.0017 18.1 0.0 0.0033 17.1 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AAS50411.1 - 0.0023 18.6 0.8 0.0023 18.6 0.8 2.0 2 2 0 2 2 2 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS50411.1 - 0.017 14.4 0.0 0.041 13.2 0.0 1.5 2 0 0 2 2 2 0 Serine aminopeptidase, S33 UPF0227 PF05728.12 AAS50411.1 - 0.033 14.1 0.0 0.058 13.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DUF2974 PF11187.8 AAS50411.1 - 0.18 11.4 0.0 0.37 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.7 AAS50411.1 - 0.18 11.5 0.0 0.33 10.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Phos_pyr_kin PF08543.12 AAS50412.1 - 8.4e-08 31.9 0.0 1.1e-07 31.5 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 AAS50412.1 - 6.1e-06 25.7 0.1 8.6e-06 25.3 0.1 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phage_TAC_6 PF09550.10 AAS50412.1 - 0.042 14.3 0.4 0.13 12.8 0.4 1.8 1 0 0 1 1 1 0 Phage tail assembly chaperone protein, TAC ANAPC4_WD40 PF12894.7 AAS50413.1 - 2.5e-05 24.5 0.0 0.39 11.1 0.0 2.9 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS50413.1 - 5.3e-05 23.9 0.1 3.4 8.7 0.1 4.0 3 0 0 3 3 3 2 WD domain, G-beta repeat zf-C3HC4_2 PF13923.6 AAS50414.1 - 1.8e-13 50.1 14.5 2.3e-13 49.8 11.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS50414.1 - 1.9e-10 40.4 15.9 4.2e-10 39.3 11.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAP PF02037.27 AAS50414.1 - 1.5e-09 37.4 0.0 3.7e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 SAP domain zf-RING_UBOX PF13445.6 AAS50414.1 - 1.1e-08 34.9 14.3 5.3e-08 32.8 8.4 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_6 PF14835.6 AAS50414.1 - 6.6e-08 32.3 3.8 1.5e-07 31.2 3.8 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-C3HC4_3 PF13920.6 AAS50414.1 - 7.2e-08 32.2 13.1 1.2e-07 31.4 8.0 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AAS50414.1 - 1.4e-07 31.6 13.4 3.4e-07 30.3 10.2 2.4 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 AAS50414.1 - 3.2e-07 30.6 14.0 5.2e-07 29.9 9.9 2.4 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 AAS50414.1 - 4.2e-07 29.8 14.2 6.8e-07 29.1 9.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AAS50414.1 - 4.2e-06 26.5 11.5 3.6e-05 23.5 7.6 2.6 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 AAS50414.1 - 2.1e-05 24.7 5.4 2.1e-05 24.7 5.4 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_10 PF16685.5 AAS50414.1 - 0.0034 17.5 8.7 0.0034 17.5 8.7 1.7 2 0 0 2 2 2 1 zinc RING finger of MSL2 cIII PF08134.11 AAS50414.1 - 0.03 14.1 0.4 0.061 13.1 0.4 1.5 1 0 0 1 1 1 0 cIII protein family U-box PF04564.15 AAS50414.1 - 0.084 13.1 0.0 0.24 11.6 0.0 1.7 1 0 0 1 1 1 0 U-box domain zf-C2HC_2 PF13913.6 AAS50414.1 - 0.099 12.6 0.4 0.099 12.6 0.4 2.7 3 0 0 3 3 2 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 AAS50414.1 - 0.13 12.6 6.4 1.3 9.4 0.1 3.0 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-Nse PF11789.8 AAS50414.1 - 0.18 11.7 11.8 0.032 14.1 5.0 2.7 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit zf-ANAPC11 PF12861.7 AAS50414.1 - 0.55 10.3 4.8 0.28 11.2 2.4 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 AAS50414.1 - 2.3 8.1 12.4 0.56 10.1 6.4 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Forkhead PF00250.18 AAS50415.1 - 8.1e-32 109.3 0.0 1.4e-31 108.6 0.0 1.4 1 0 0 1 1 1 1 Forkhead domain G10 PF01125.17 AAS50416.2 - 3.3e-57 192.4 0.1 3.5e-57 192.3 0.1 1.0 1 0 0 1 1 1 1 G10 protein Ytp1 PF10355.9 AAS50417.1 - 1.3e-106 355.8 4.0 1.8e-106 355.4 4.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (Ytp1) DUF2427 PF10348.9 AAS50417.1 - 2.3e-28 98.0 3.5 2.3e-28 98.0 3.5 2.7 3 0 0 3 3 3 1 Domain of unknown function (DUF2427) Glucan_synthase PF02364.15 AAS50418.1 - 0 1113.9 1.2 0 1113.4 1.2 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AAS50418.1 - 4.5e-25 88.5 4.6 9.8e-24 84.1 4.6 2.7 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF4640 PF15480.6 AAS50418.1 - 0.0013 18.5 0.2 0.014 15.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4640) Ctr PF04145.15 AAS50418.1 - 0.011 16.4 3.6 0.016 15.8 0.4 2.9 3 0 0 3 3 3 0 Ctr copper transporter family TPR_1 PF00515.28 AAS50419.1 - 4.6e-08 32.5 0.7 0.0061 16.3 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50419.1 - 1.3e-07 31.2 1.0 0.0018 18.3 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS50419.1 - 2.4e-05 24.5 0.1 0.0042 17.3 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AAS50419.1 - 8.4e-05 22.2 0.2 0.0017 18.0 0.2 2.4 3 0 0 3 3 3 1 TPR repeat TPR_7 PF13176.6 AAS50419.1 - 9.2e-05 22.2 0.0 0.74 10.0 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50419.1 - 0.0002 21.8 0.0 0.00034 21.1 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS50419.1 - 0.00061 20.0 0.1 0.0011 19.2 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 AAS50419.1 - 0.00071 19.4 0.1 0.022 14.6 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS50419.1 - 0.0023 18.5 0.1 0.0066 17.1 0.1 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_MalT PF17874.1 AAS50419.1 - 0.0082 15.6 0.1 0.0092 15.4 0.1 1.1 1 0 0 1 1 1 1 MalT-like TPR region Fis1_TPR_C PF14853.6 AAS50419.1 - 0.033 14.3 0.3 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_17 PF13431.6 AAS50419.1 - 0.045 14.2 0.6 0.49 10.9 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 AAS50419.1 - 0.056 13.5 0.0 0.16 12.0 0.0 1.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) SRP_TPR_like PF17004.5 AAS50419.1 - 0.066 13.2 0.7 0.94 9.5 0.0 2.2 1 1 1 2 2 2 0 Putative TPR-like repeat TPR_8 PF13181.6 AAS50419.1 - 0.099 12.9 2.1 5.3 7.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat UPF0029 PF01205.19 AAS50420.1 - 9.1e-32 109.5 0.0 1.4e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 AAS50420.1 - 1.6e-11 44.5 1.2 3.9e-11 43.3 1.2 1.7 1 1 0 1 1 1 1 RWD domain MPP6 PF10175.9 AAS50421.1 - 1.8e-18 67.3 0.0 2.3e-18 66.9 0.0 1.1 1 0 0 1 1 1 1 M-phase phosphoprotein 6 DUF4317 PF14199.6 AAS50421.1 - 0.16 11.1 0.1 0.2 10.8 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4317) WD40 PF00400.32 AAS50422.1 - 1.2e-46 155.7 7.2 3.1e-09 37.3 0.1 12.6 13 0 0 13 13 13 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50422.1 - 2.5e-32 111.0 0.0 0.00018 21.8 0.0 9.0 4 2 5 10 10 10 8 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 AAS50422.1 - 1.2e-25 89.8 0.0 2.1e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family Ge1_WD40 PF16529.5 AAS50422.1 - 7.6e-10 38.2 5.5 0.08 11.9 0.0 7.4 5 3 3 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AAS50422.1 - 6.8e-07 29.4 4.5 0.021 14.7 0.0 6.3 5 2 2 7 7 7 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AAS50422.1 - 9.7e-07 28.4 0.8 0.47 9.7 0.0 5.1 5 0 0 5 5 5 2 WD40-like domain SGL PF08450.12 AAS50422.1 - 1.2e-05 25.0 0.5 0.17 11.4 0.0 3.7 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Nbas_N PF15492.6 AAS50422.1 - 3.8e-05 23.2 0.2 0.81 9.0 0.0 4.2 3 1 0 3 3 3 2 Neuroblastoma-amplified sequence, N terminal WD40_3 PF15911.5 AAS50422.1 - 0.0018 18.2 0.0 0.011 15.7 0.1 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 AAS50422.1 - 0.014 13.9 0.3 1.2 7.6 0.0 3.6 2 2 0 4 4 4 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 AAS50422.1 - 0.058 12.3 0.0 9.4 5.0 0.0 2.5 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain BAALC_N PF06989.12 AAS50422.1 - 0.2 12.0 1.7 7.6 6.9 0.4 2.5 2 0 0 2 2 2 0 BAALC N-terminus Atx10homo_assoc PF09759.9 AAS50423.1 - 7.8e-40 134.9 0.8 3.3e-39 132.9 0.2 2.3 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Thr_synth_N PF14821.6 AAS50424.1 - 2.9e-26 91.5 0.0 1.1e-25 89.6 0.0 2.1 1 0 0 1 1 1 1 Threonine synthase N terminus PALP PF00291.25 AAS50424.1 - 3.7e-10 39.7 0.0 7.8e-10 38.6 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme SWIB PF02201.18 AAS50425.1 - 0.0013 18.6 0.0 0.009 15.9 0.0 2.4 1 1 0 1 1 1 1 SWIB/MDM2 domain ACCA PF03255.14 AAS50425.1 - 0.11 12.3 0.2 2.3 8.1 0.0 2.6 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ribosomal_L9_N PF01281.19 AAS50426.1 - 6.8e-05 22.3 0.0 0.00013 21.4 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain PilJ PF13675.6 AAS50426.1 - 0.012 15.7 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF1682 PF07946.14 AAS50427.1 - 1.2e-71 241.6 0.8 1.5e-71 241.2 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) HEPN_AbiU2 PF18734.1 AAS50427.1 - 0.061 12.8 2.2 0.14 11.6 2.2 1.7 1 0 0 1 1 1 0 AbiU2 Ank_5 PF13857.6 AAS50428.1 - 4.2e-18 65.2 2.8 1e-14 54.4 0.9 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AAS50428.1 - 4.5e-17 62.2 3.5 4.5e-09 36.7 0.3 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 AAS50428.1 - 2e-14 53.9 0.1 5.3e-14 52.6 0.1 1.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 AAS50428.1 - 8.4e-12 45.0 4.3 4.2e-05 23.8 0.3 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 AAS50428.1 - 2.8e-10 39.5 1.1 8.9e-06 25.7 0.2 4.4 4 1 0 4 4 4 2 Ankyrin repeat Peptidase_M76 PF09768.9 AAS50429.1 - 4.6e-70 234.8 1.2 5.7e-70 234.5 1.2 1.1 1 0 0 1 1 1 1 Peptidase M76 family Chromo PF00385.24 AAS50429.1 - 0.0084 16.0 0.1 0.026 14.4 0.1 1.9 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain MBOAT PF03062.19 AAS50430.1 - 1.1e-67 228.8 39.8 1.3e-67 228.6 39.8 1.1 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family MBOAT_2 PF13813.6 AAS50430.1 - 0.0045 17.2 5.3 0.0045 17.2 5.3 2.0 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family WBS_methylT PF12589.8 AAS50431.1 - 5.9e-13 49.4 8.1 1.1e-12 48.5 8.1 1.5 1 0 0 1 1 1 1 Methyltransferase involved in Williams-Beuren syndrome Methyltransf_11 PF08241.12 AAS50431.1 - 4.5e-12 46.5 0.0 9.6e-12 45.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS50431.1 - 3.8e-10 40.3 0.2 1.5e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS50431.1 - 2.6e-05 24.9 0.0 8e-05 23.3 0.0 1.9 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS50431.1 - 0.0012 18.6 0.0 0.0038 17.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS50431.1 - 0.0023 17.8 0.0 0.0035 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AAS50431.1 - 0.0027 17.0 0.1 0.061 12.6 0.0 2.4 2 1 0 2 2 2 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.13 AAS50431.1 - 0.0038 17.5 0.0 0.0097 16.2 0.0 1.7 2 0 0 2 2 2 1 Predicted AdoMet-dependent methyltransferase PCMT PF01135.19 AAS50431.1 - 0.0046 16.7 0.0 0.02 14.6 0.0 2.0 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 AAS50431.1 - 0.013 15.5 0.2 0.53 10.3 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain MetW PF07021.12 AAS50431.1 - 0.014 15.0 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 AAS50431.1 - 0.024 14.0 0.2 0.12 11.7 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L11 methyltransferase (PrmA) Ribosomal_L19 PF01245.20 AAS50432.1 - 6e-09 35.8 0.1 9.7e-09 35.1 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L19 HIG_1_N PF04588.13 AAS50433.1 - 2.1e-06 27.8 0.3 3.7e-06 27.1 0.3 1.4 1 0 0 1 1 1 1 Hypoxia induced protein conserved region Peptidase_S8 PF00082.22 AAS50434.2 - 2.6e-33 115.6 2.6 1.5e-32 113.1 2.6 2.0 1 1 0 1 1 1 1 Subtilase family SDA1 PF05285.12 AAS50434.2 - 0.079 12.4 11.2 0.12 11.8 11.2 1.1 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 AAS50434.2 - 1.1 9.1 8.1 2 8.3 8.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 AAS50434.2 - 2.3 6.3 19.5 3.3 5.8 19.5 1.1 1 0 0 1 1 1 0 Nop14-like family Tim17 PF02466.19 AAS50435.1 - 3.7e-27 94.9 2.6 5.7e-27 94.3 2.6 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family Bacteriocin_IIc PF10439.9 AAS50435.1 - 1.7 8.8 9.4 6.8 6.9 1.3 2.6 2 1 0 2 2 2 0 Bacteriocin class II with double-glycine leader peptide ACC_central PF08326.12 AAS50436.1 - 4.2e-262 871.7 0.1 5.8e-262 871.2 0.1 1.2 1 0 0 1 1 1 1 Acetyl-CoA carboxylase, central region Carboxyl_trans PF01039.22 AAS50436.1 - 5.6e-182 605.8 0.0 7.4e-182 605.4 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain CPSase_L_D2 PF02786.17 AAS50436.1 - 2e-51 174.5 0.0 4.3e-51 173.4 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 AAS50436.1 - 6.7e-29 100.7 0.0 1.5e-28 99.5 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AAS50436.1 - 1.6e-20 73.2 0.0 8.2e-20 70.9 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 AAS50436.1 - 3.6e-17 61.9 0.0 2.4e-16 59.3 0.0 2.4 2 0 0 2 2 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AAS50436.1 - 0.0023 17.5 0.0 0.0085 15.6 0.0 2.0 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus ATP-grasp_3 PF02655.14 AAS50436.1 - 0.011 15.7 0.0 0.076 13.1 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 AAS50436.1 - 0.051 13.4 0.0 1.6 8.6 0.0 2.8 1 1 1 2 2 2 0 Biotin-lipoyl like ABC_tran_CTD PF16326.5 AAS50436.1 - 0.18 12.1 7.7 0.076 13.3 3.5 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain Dus PF01207.17 AAS50437.1 - 5.5e-51 173.5 0.0 1.2e-50 172.4 0.0 1.6 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF1708 PF08101.11 AAS50438.1 - 3.4e-81 273.6 0.3 4.7e-81 273.2 0.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) DUF4667 PF15700.5 AAS50439.1 - 5.7e-41 141.2 0.0 9.3e-37 127.4 0.0 2.0 1 1 1 2 2 2 2 Domain of unknown function (DUF4667) Zn_ribbon_SprT PF17283.2 AAS50439.1 - 0.089 12.7 0.4 0.089 12.7 0.4 1.8 2 0 0 2 2 2 0 SprT-like zinc ribbon domain PRELI PF04707.14 AAS50440.1 - 3.5e-42 143.9 0.0 4.2e-42 143.6 0.0 1.0 1 0 0 1 1 1 1 PRELI-like family NMT_C PF02799.15 AAS50442.1 - 3.6e-78 261.9 0.0 6.8e-78 261.0 0.0 1.4 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 AAS50442.1 - 8.9e-74 246.7 0.0 2.2e-73 245.4 0.0 1.6 2 0 0 2 2 2 1 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Acetyltransf_9 PF13527.7 AAS50442.1 - 0.00047 20.2 0.0 0.0097 16.0 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AAS50442.1 - 0.0062 16.8 0.0 0.017 15.4 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family WD40 PF00400.32 AAS50443.1 - 2.1e-07 31.5 10.0 0.011 16.5 0.5 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat Nup160 PF11715.8 AAS50443.1 - 1.1e-05 24.3 1.2 2.8e-05 23.0 0.6 1.7 2 0 0 2 2 2 1 Nucleoporin Nup120/160 PQQ_3 PF13570.6 AAS50443.1 - 0.095 13.2 0.1 2.8 8.5 0.0 3.3 4 0 0 4 4 4 0 PQQ-like domain ATG22 PF11700.8 AAS50445.2 - 1.4e-138 462.6 17.7 1.6e-138 462.4 17.7 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like DUF5355 PF17306.2 AAS50446.1 - 4.6e-34 117.9 0.0 1.3e-33 116.4 0.0 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5355) Ammonium_transp PF00909.21 AAS50447.1 - 1.5e-116 389.4 21.7 1.7e-116 389.2 21.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family 7TM_GPCR_Sri PF10327.9 AAS50447.1 - 0.01 15.0 0.0 0.028 13.6 0.0 1.7 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri Metallophos PF00149.28 AAS50448.2 - 2e-32 113.4 0.1 2.8e-32 112.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 AAS50448.2 - 3.8e-22 78.4 0.0 9e-22 77.2 0.0 1.7 2 0 0 2 2 2 1 PPP5 TPR repeat region TPR_1 PF00515.28 AAS50448.2 - 8.9e-08 31.6 3.5 0.0025 17.6 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50448.2 - 1.7e-07 30.8 4.2 0.01 15.9 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 AAS50448.2 - 1.3e-05 24.8 0.2 0.087 12.5 0.1 2.6 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 AAS50448.2 - 0.00039 20.6 0.1 2.1 8.9 0.0 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 AAS50448.2 - 0.00045 20.3 6.0 0.00063 19.8 1.4 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50448.2 - 0.0049 17.0 0.6 2.2 8.7 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS50448.2 - 0.11 13.2 6.7 0.092 13.4 2.9 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat Kelch_4 PF13418.6 AAS50448.2 - 0.13 12.3 0.2 0.29 11.2 0.0 1.7 2 0 0 2 2 1 0 Galactose oxidase, central domain TPR_19 PF14559.6 AAS50448.2 - 0.15 12.6 1.2 0.73 10.4 0.4 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS50448.2 - 0.43 10.7 1.8 7.9 6.8 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 AAS50448.2 - 1 9.7 3.4 3.2 8.1 1.9 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat ADH_N PF08240.12 AAS50449.2 - 4.4e-30 103.8 0.4 1e-29 102.6 0.4 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS50449.2 - 1.4e-25 89.8 1.4 2.1e-25 89.2 1.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AAS50449.2 - 5.1e-06 27.6 0.1 8.6e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NqrM PF04400.13 AAS50449.2 - 1.9 8.3 6.4 0.17 11.6 0.5 2.1 2 0 0 2 2 2 0 (Na+)-NQR maturation NqrM TRAM_LAG1_CLN8 PF03798.16 AAS50450.1 - 4.6e-29 101.6 10.3 4.6e-29 101.6 10.3 1.7 2 0 0 2 2 2 1 TLC domain PH PF00169.29 AAS50451.1 - 6.3e-06 26.7 0.4 4.8e-05 23.8 0.0 2.7 3 0 0 3 3 3 1 PH domain YgaB PF14182.6 AAS50451.1 - 0.12 12.8 0.8 2.8 8.4 0.0 2.9 3 0 0 3 3 3 0 YgaB-like protein BORCS6 PF10157.9 AAS50451.1 - 0.18 12.0 1.1 0.57 10.4 0.7 2.0 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Apolipoprotein PF01442.18 AAS50451.1 - 0.88 9.4 7.2 0.57 10.0 2.0 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Flavin_Reduct PF01613.18 AAS50452.1 - 5.7e-26 91.4 0.3 1.2e-25 90.4 0.3 1.5 1 1 0 1 1 1 1 Flavin reductase like domain RRG8 PF17068.5 AAS50453.2 - 1.6e-120 401.7 0.0 1.8e-120 401.6 0.0 1.0 1 0 0 1 1 1 1 Required for respiratory growth protein 8 mitochondrial Peptidase_C50 PF03568.17 AAS50454.2 - 7e-127 423.8 0.0 1.7e-126 422.6 0.0 1.7 1 0 0 1 1 1 1 Peptidase family C50 CHAT PF12770.7 AAS50454.2 - 0.17 11.3 0.0 0.39 10.1 0.0 1.5 1 0 0 1 1 1 0 CHAT domain Telomere_reg-2 PF10193.9 AAS50455.1 - 3.9e-21 75.6 2.5 3.9e-21 75.6 2.5 2.5 2 0 0 2 2 2 1 Telomere length regulation protein Imm47 PF15573.6 AAS50455.1 - 0.051 13.1 0.1 0.093 12.2 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 47 RabGAP-TBC PF00566.18 AAS50456.1 - 1.9e-50 171.5 1.0 5.5e-50 170.0 0.1 2.2 2 0 0 2 2 2 1 Rab-GTPase-TBC domain GRAM PF02893.20 AAS50456.1 - 3.4e-15 55.9 0.4 8.3e-15 54.7 0.0 1.9 2 0 0 2 2 2 1 GRAM domain Vps36_ESCRT-II PF11605.8 AAS50456.1 - 0.005 17.0 0.0 0.019 15.2 0.0 2.0 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 AAS50456.1 - 0.15 12.4 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 TFIIH p62 subunit, N-terminal domain EF-hand_6 PF13405.6 AAS50456.1 - 0.28 11.2 3.6 21 5.4 0.0 3.5 4 0 0 4 4 4 0 EF-hand domain Rhomboid PF01694.22 AAS50457.2 - 3.3e-31 108.3 15.5 3.3e-31 108.3 15.5 1.7 2 0 0 2 2 2 1 Rhomboid family Romo1 PF10247.9 AAS50457.2 - 0.059 13.7 1.7 1.2 9.6 0.2 3.1 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 HlyD_D4 PF16572.5 AAS50458.1 - 0.0042 16.9 0.0 0.0085 15.9 0.0 1.6 1 0 0 1 1 1 1 Long alpha hairpin domain of cation efflux system protein, CusB Glu-tRNAGln PF02686.15 AAS50458.1 - 0.017 15.4 0.0 0.043 14.1 0.0 1.7 1 1 0 1 1 1 0 Glu-tRNAGln amidotransferase C subunit SelB-wing_1 PF09105.10 AAS50458.1 - 0.072 13.1 0.3 0.48 10.4 0.1 2.3 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Pescadillo_N PF06732.11 AAS50459.1 - 1.5e-120 401.9 1.8 1.5e-120 401.9 1.8 2.0 2 0 0 2 2 2 1 Pescadillo N-terminus BRCT_2 PF16589.5 AAS50459.1 - 1.1e-09 38.5 0.0 3.4e-09 37.0 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain QSOX_Trx1 PF18108.1 AAS50459.1 - 0.026 14.7 0.0 13 6.1 0.0 2.6 2 0 0 2 2 2 0 QSOX Trx-like domain BRCT PF00533.26 AAS50459.1 - 0.027 14.8 0.3 0.1 13.0 0.3 2.1 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Med18 PF09637.10 AAS50460.1 - 1.4e-68 231.5 0.0 1.5e-68 231.3 0.0 1.0 1 0 0 1 1 1 1 Med18 protein VMA21 PF09446.10 AAS50461.1 - 1.6e-09 37.7 16.4 1.4e-08 34.7 16.4 1.9 1 1 0 1 1 1 1 VMA21-like domain ATP-synt_S1 PF05827.12 AAS50462.1 - 0.28 11.0 0.6 0.44 10.4 0.6 1.2 1 0 0 1 1 1 0 Vacuolar ATP synthase subunit S1 (ATP6S1) IF-2B PF01008.17 AAS50463.1 - 1.4e-70 237.7 0.0 1.7e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 Initiation factor 2 subunit family Cyclin_N PF00134.23 AAS50464.1 - 8e-40 135.5 0.2 1.9e-39 134.3 0.1 1.7 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AAS50464.1 - 3.2e-31 107.9 0.1 1.6e-30 105.6 0.0 2.3 2 0 0 2 2 2 1 Cyclin, C-terminal domain Cyclin_N PF00134.23 AAS50465.1 - 4.1e-38 130.0 2.2 6.6e-38 129.3 2.2 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AAS50465.1 - 1.2e-14 54.4 0.1 2.7e-14 53.3 0.1 1.6 1 0 0 1 1 1 1 Cyclin, C-terminal domain RPN1_RPN2_N PF17781.1 AAS50465.1 - 0.012 15.1 0.2 0.021 14.2 0.2 1.4 1 0 0 1 1 1 0 RPN1/RPN2 N-terminal domain PAP1 PF08601.10 AAS50466.1 - 1.5 8.5 14.0 1.9 8.1 14.0 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 WD40 PF00400.32 AAS50467.1 - 2.4e-18 66.1 1.4 6.3e-05 23.7 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat WD40_like PF17005.5 AAS50467.1 - 0.045 13.1 0.0 0.76 9.0 0.0 2.5 3 0 0 3 3 3 0 WD40-like domain YABBY PF04690.13 AAS50467.1 - 0.17 12.5 2.8 0.14 12.7 1.3 1.7 2 0 0 2 2 2 0 YABBY protein Mcl1_mid PF12341.8 AAS50468.1 - 2e-82 276.9 0.0 3.1e-80 269.7 0.0 2.7 3 0 0 3 3 3 2 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 AAS50468.1 - 1.7e-08 34.6 0.1 0.16 12.3 0.0 4.8 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS50468.1 - 0.00011 21.7 0.0 0.41 9.9 0.0 2.5 3 0 0 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 AAS50468.1 - 0.076 13.1 0.0 86 3.2 0.0 3.8 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Dysbindin PF04440.16 AAS50468.1 - 0.077 13.2 1.5 0.16 12.1 0.0 2.1 3 0 0 3 3 3 0 Dysbindin (Dystrobrevin binding protein 1) COG2 PF06148.11 AAS50469.1 - 2.3e-06 27.7 6.4 2.3e-06 27.7 6.4 1.8 1 1 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 PRD PF00874.20 AAS50469.1 - 0.08 13.3 1.1 4.3 7.7 0.2 2.4 2 0 0 2 2 2 0 PRD domain MCM_N PF14551.6 AAS50469.1 - 0.091 13.4 3.0 1.3 9.6 0.3 3.2 1 1 1 2 2 2 0 MCM N-terminal domain CALM_bind PF16025.5 AAS50469.1 - 0.13 12.7 0.1 0.31 11.5 0.1 1.6 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Med4 PF10018.9 AAS50469.1 - 0.51 10.0 3.4 0.57 9.8 0.8 2.0 1 1 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Nup54 PF13874.6 AAS50470.1 - 2.3e-35 121.7 3.4 2.3e-35 121.7 3.4 1.9 2 0 0 2 2 2 1 Nucleoporin complex subunit 54 Nucleoporin_FG PF13634.6 AAS50470.1 - 9.3e-28 96.9 307.2 1.5e-09 38.6 39.2 5.9 1 1 7 8 8 8 7 Nucleoporin FG repeat region TFIIA PF03153.13 AAS50470.1 - 0.06 13.3 16.2 0.085 12.8 16.2 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tom5 PF10642.9 AAS50471.1 - 7.7e-22 77.1 0.7 8.5e-22 76.9 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase Med26 PF08711.11 AAS50472.1 - 8.1e-12 45.0 0.1 2.7e-11 43.3 0.1 2.0 1 0 0 1 1 1 1 TFIIS helical bundle-like domain Ribosom_S12_S23 PF00164.25 AAS50473.1 - 1.2e-51 173.1 0.4 1.5e-51 172.8 0.4 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 ATP19 PF11022.8 AAS50474.1 - 2.1e-16 60.0 0.0 2.3e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K RNA_Me_trans PF04252.13 AAS50475.1 - 1.2e-77 260.1 0.0 1.3e-77 259.9 0.0 1.0 1 0 0 1 1 1 1 Predicted SAM-dependent RNA methyltransferase DDHD PF02862.17 AAS50476.1 - 3.5e-31 109.1 0.4 2.9e-21 76.6 0.0 2.8 2 1 1 3 3 3 2 DDHD domain LCAT PF02450.15 AAS50476.1 - 4.5e-05 22.8 0.1 0.00061 19.1 0.0 2.1 2 0 0 2 2 2 1 Lecithin:cholesterol acyltransferase DUF676 PF05057.14 AAS50476.1 - 0.00019 21.0 0.2 0.011 15.3 0.0 2.2 2 0 0 2 2 2 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AAS50476.1 - 0.026 14.3 0.0 0.053 13.4 0.0 1.4 1 0 0 1 1 1 0 Palmitoyl protein thioesterase PGAP1 PF07819.13 AAS50476.1 - 0.14 11.8 0.0 0.29 10.8 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein ISN1 PF06437.11 AAS50478.1 - 5.5e-168 559.1 0.0 7.4e-168 558.7 0.0 1.2 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Choline_transpo PF04515.12 AAS50479.1 - 6.4e-80 268.8 21.3 6.4e-80 268.8 21.3 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter FixP_N PF14715.6 AAS50479.1 - 0.14 11.9 3.4 15 5.4 0.1 3.7 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Xpo1 PF08389.12 AAS50481.2 - 3.6e-30 105.0 0.7 7.4e-29 100.7 0.3 3.2 2 0 0 2 2 2 1 Exportin 1-like protein IBN_N PF03810.19 AAS50481.2 - 1.5e-07 31.2 1.0 1.3e-06 28.2 0.2 2.9 1 1 1 2 2 2 1 Importin-beta N-terminal domain Hrs_helical PF12210.8 AAS50481.2 - 0.047 14.2 0.1 0.14 12.7 0.1 1.7 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate FPRL1_inhibitor PF16104.5 AAS50481.2 - 0.074 13.2 0.0 0.17 12.0 0.0 1.6 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein BioT2 PF15368.6 AAS50481.2 - 0.14 12.1 0.3 0.62 10.0 0.1 2.2 2 0 0 2 2 2 0 Spermatogenesis family BioT2 RNA_POL_M_15KD PF02150.16 AAS50481.2 - 0.16 11.8 2.5 9.1 6.2 0.1 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit LSM PF01423.22 AAS50482.1 - 2.6e-13 49.5 0.1 3e-13 49.2 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AAS50482.1 - 0.019 14.6 0.1 0.033 13.8 0.1 1.4 1 0 0 1 1 1 0 Hfq protein A_deaminase_N PF08451.11 AAS50483.1 - 0.092 13.1 4.3 0.13 12.5 2.7 2.2 1 1 0 1 1 1 0 Adenosine/AMP deaminase N-terminal RE_Eco47II PF09553.10 AAS50483.1 - 0.2 11.2 0.4 1.1 8.8 0.4 2.0 1 1 0 1 1 1 0 Eco47II restriction endonuclease TRAPPC9-Trs120 PF08626.11 AAS50484.1 - 4.1e-291 968.5 0.0 4.8e-291 968.3 0.0 1.0 1 0 0 1 1 1 1 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit IL6Ra-bind PF09240.10 AAS50484.1 - 0.047 14.1 0.4 1 9.8 0.1 2.5 2 0 0 2 2 2 0 Interleukin-6 receptor alpha chain, binding RET_CLD3 PF17812.1 AAS50484.1 - 0.065 13.5 0.3 24 5.2 0.0 2.9 3 0 0 3 3 3 0 RET Cadherin like domain 3 Proteasome PF00227.26 AAS50485.1 - 2.7e-45 154.2 0.1 3.3e-45 153.9 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 AAS50485.1 - 3.2e-10 39.2 0.1 3.2e-10 39.2 0.1 1.7 2 0 0 2 2 2 1 Proteasome beta subunits C terminal Formyl_trans_N PF00551.19 AAS50486.2 - 2.1e-52 177.5 0.0 2.5e-52 177.3 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase MannoseP_isomer PF01050.18 AAS50486.2 - 0.13 12.2 0.1 0.24 11.3 0.1 1.4 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase PINIT PF14324.6 AAS50487.1 - 1.9e-32 112.6 0.1 4.4e-32 111.4 0.1 1.7 1 0 0 1 1 1 1 PINIT domain zf-MIZ PF02891.20 AAS50487.1 - 2e-21 75.4 6.8 3.7e-21 74.6 6.8 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger SAP PF02037.27 AAS50487.1 - 1.4e-12 47.1 0.0 2.4e-12 46.3 0.0 1.4 1 0 0 1 1 1 1 SAP domain zf-Nse PF11789.8 AAS50487.1 - 1.5e-07 31.1 2.0 3.7e-07 29.9 2.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AAS50487.1 - 0.04 13.9 1.7 0.059 13.4 0.3 2.1 1 1 1 2 2 2 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AAS50487.1 - 0.19 11.6 4.6 0.25 11.2 3.6 1.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS50487.1 - 0.25 11.2 0.8 0.45 10.4 0.4 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS50487.1 - 0.46 10.4 2.2 0.83 9.6 2.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS50487.1 - 0.47 10.4 1.7 1 9.3 1.7 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AAS50487.1 - 0.53 10.5 4.1 0.97 9.6 4.1 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cwf_Cwc_15 PF04889.12 AAS50487.1 - 1.1 8.9 7.7 2.1 8.0 7.7 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ICMT PF04140.14 AAS50488.1 - 3.8e-27 94.6 0.7 9.4e-27 93.3 0.7 1.6 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 AAS50488.1 - 1.7e-13 50.9 1.9 1.7e-13 50.9 1.9 2.4 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 AAS50488.1 - 2e-05 24.3 1.5 2.6e-05 23.9 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) NnrU PF07298.11 AAS50488.1 - 0.0054 16.3 1.1 0.0092 15.5 1.1 1.4 1 0 0 1 1 1 1 NnrU protein DUF4281 PF14108.6 AAS50488.1 - 0.021 15.2 1.5 0.037 14.4 0.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4281) Svf1_C PF17187.4 AAS50488.1 - 0.027 14.3 0.0 0.044 13.6 0.0 1.3 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain Peptidase_M48_N PF16491.5 AAS50488.1 - 2.9 7.7 8.2 0.17 11.8 2.9 1.7 2 0 0 2 2 2 0 CAAX prenyl protease N-terminal, five membrane helices zf-HIT PF04438.16 AAS50489.1 - 0.017 15.0 11.1 0.017 15.0 11.1 1.8 2 0 0 2 2 2 0 HIT zinc finger Carn_acyltransf PF00755.20 AAS50490.1 - 8.4e-175 582.8 0.0 9.5e-175 582.6 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Fur_reg_FbpA PF13076.6 AAS50490.1 - 0.13 12.0 1.5 0.21 11.3 0.2 2.0 2 0 0 2 2 2 0 Fur-regulated basic protein A DER1 PF04511.15 AAS50491.1 - 6.2e-28 98.0 4.0 8e-28 97.7 4.0 1.1 1 0 0 1 1 1 1 Der1-like family Thioredoxin PF00085.20 AAS50491.1 - 1.6e-22 79.4 0.0 3.1e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AAS50491.1 - 0.00023 21.6 0.1 0.00073 20.0 0.1 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain GPDPase_memb PF10110.9 AAS50491.1 - 0.019 13.8 0.1 0.031 13.1 0.1 1.3 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase Thioredoxin_8 PF13905.6 AAS50491.1 - 0.078 13.3 0.0 0.15 12.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 AAS50491.1 - 0.092 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Nop25 PF09805.9 AAS50492.1 - 1.8e-32 112.7 12.1 1.8e-32 112.7 12.1 2.5 3 0 0 3 3 3 1 Nucleolar protein 12 (25kDa) TniQ PF06527.11 AAS50492.1 - 0.86 10.3 3.5 0.63 10.8 1.8 1.6 2 0 0 2 2 2 0 TniQ EXS PF03124.14 AAS50493.1 - 1.4e-63 215.3 17.8 1.5e-63 215.1 17.8 1.0 1 0 0 1 1 1 1 EXS family Ribosomal_L2_C PF03947.18 AAS50494.1 - 4.7e-52 175.5 3.2 1.1e-51 174.3 3.2 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AAS50494.1 - 5.1e-27 93.6 0.9 1.2e-26 92.5 0.5 1.8 2 0 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain Prot_ATP_ID_OB PF16450.5 AAS50494.1 - 0.063 13.2 0.1 0.52 10.3 0.1 2.3 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain Peptidase_M28 PF04389.17 AAS50495.1 - 6.1e-31 107.7 0.1 8.1e-31 107.3 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 AAS50495.1 - 1.4e-06 28.1 0.1 3.2e-06 27.0 0.1 1.6 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Acylphosphatase PF00708.18 AAS50495.1 - 0.055 13.9 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 Acylphosphatase ATP-synt_D PF01813.17 AAS50496.1 - 2.6e-69 233.0 3.1 3.6e-69 232.5 3.1 1.2 1 0 0 1 1 1 1 ATP synthase subunit D SYCE1 PF15233.6 AAS50496.1 - 0.024 14.7 1.4 0.12 12.4 0.1 2.3 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 RICH PF05062.12 AAS50496.1 - 0.085 13.2 3.3 0.15 12.4 0.6 2.3 2 0 0 2 2 2 0 RICH domain FAM76 PF16046.5 AAS50496.1 - 5.1 6.4 5.5 8.6 5.6 5.5 1.5 1 1 0 1 1 1 0 FAM76 protein TPR_14 PF13428.6 AAS50497.2 - 1e-08 35.3 27.3 0.25 12.2 0.1 11.3 9 3 3 12 12 11 3 Tetratricopeptide repeat TPR_15 PF13429.6 AAS50497.2 - 1.3e-08 34.4 8.6 0.017 14.4 0.0 5.1 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50497.2 - 7.7e-08 32.7 13.5 0.068 13.7 0.0 6.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50497.2 - 5.4e-07 29.3 0.1 0.0065 16.6 0.0 4.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS50497.2 - 4e-05 23.8 4.6 0.24 11.7 0.0 4.9 6 0 0 6 6 4 2 Tetratricopeptide repeat Suf PF05843.14 AAS50497.2 - 0.00032 20.8 1.9 0.33 10.9 0.0 4.3 4 1 0 4 4 4 1 Suppressor of forked protein (Suf) TPR_2 PF07719.17 AAS50497.2 - 0.00042 20.2 6.5 0.72 10.1 0.0 5.4 5 0 0 5 5 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 AAS50497.2 - 0.0023 17.9 14.2 1.5 8.8 0.1 6.7 8 2 1 9 9 8 2 Mad3/BUB1 homology region 1 ANAPC3 PF12895.7 AAS50497.2 - 0.0035 17.5 11.8 0.32 11.3 0.1 4.1 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 AAS50497.2 - 0.0061 16.9 1.9 62 4.3 0.1 5.9 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 AAS50497.2 - 0.018 15.7 1.7 5.4 7.9 0.1 4.6 4 0 0 4 4 3 0 Tetratricopeptide repeat ACDC PF14733.6 AAS50497.2 - 0.039 14.3 0.1 0.4 11.0 0.0 2.7 3 0 0 3 3 3 0 AP2-coincident C-terminal NRDE-2 PF08424.10 AAS50497.2 - 0.063 12.4 15.6 0.088 11.9 0.2 4.7 4 2 0 4 4 4 0 NRDE-2, necessary for RNA interference EIAV_Rev PF11129.8 AAS50497.2 - 0.092 12.9 0.5 0.35 11.1 0.5 2.0 2 0 0 2 2 1 0 Rev protein of equine infectious anaemia virus TPR_7 PF13176.6 AAS50497.2 - 0.3 11.2 2.0 13 6.0 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 AAS50497.2 - 4.1 7.4 0.0 4.1 7.4 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat AFG1_ATPase PF03969.16 AAS50498.1 - 6.5e-76 255.6 0.0 1.3e-72 244.7 0.0 2.7 2 1 0 2 2 2 2 AFG1-like ATPase AAA_16 PF13191.6 AAS50498.1 - 7.6e-06 26.4 1.4 5.8e-05 23.5 0.3 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AAS50498.1 - 0.00047 20.4 0.0 0.00095 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AAS50498.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA PF00004.29 AAS50498.1 - 0.019 15.4 0.0 0.039 14.4 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AAS50498.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 AAS50498.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 AAS50498.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Bac_DnaA PF00308.18 AAS50498.1 - 0.19 11.5 0.0 0.39 10.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Mak10 PF04112.13 AAS50499.1 - 1.9e-40 138.1 0.0 4.2e-40 137.0 0.0 1.6 1 0 0 1 1 1 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Spore_III_AB PF09548.10 AAS50499.1 - 0.055 13.6 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Ribosomal_L11_N PF03946.14 AAS50500.1 - 1.9e-21 75.7 0.5 5.4e-21 74.2 0.2 1.8 2 0 0 2 2 2 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AAS50500.1 - 3.9e-15 56.1 0.9 6.1e-15 55.5 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain ACBP PF00887.19 AAS50501.1 - 7.7e-20 70.9 0.0 1.5e-19 70.0 0.0 1.5 1 0 0 1 1 1 1 Acyl CoA binding protein IMS PF00817.20 AAS50502.2 - 2.8e-41 141.0 0.0 4.3e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 AAS50502.2 - 2.7e-06 28.0 0.0 7.6e-06 26.6 0.0 1.7 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain zf_UBZ PF18439.1 AAS50502.2 - 0.00091 18.8 0.1 0.002 17.7 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-Binding Zinc Finger UBZ_FAAP20 PF15750.5 AAS50502.2 - 0.026 14.4 0.6 0.065 13.2 0.6 1.7 1 0 0 1 1 1 0 Ubiquitin-binding zinc-finger zf-C2H2_4 PF13894.6 AAS50502.2 - 0.11 13.4 0.0 0.35 11.8 0.0 1.9 1 0 0 1 1 1 0 C2H2-type zinc finger UPF0547 PF10571.9 AAS50502.2 - 0.76 9.9 4.6 17 5.6 1.8 3.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 MAP65_ASE1 PF03999.12 AAS50503.1 - 1.1e-93 315.0 34.4 1.9e-93 314.2 34.4 1.4 1 0 0 1 1 1 1 Microtubule associated protein (MAP65/ASE1 family) Spore_III_AB PF09548.10 AAS50503.1 - 0.13 12.4 12.8 0.13 12.3 0.2 4.0 4 1 0 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) DUF4640 PF15480.6 AAS50503.1 - 0.96 9.1 10.7 1.9 8.1 2.7 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4640) KLRAQ PF10205.9 AAS50503.1 - 3.1 8.1 8.0 0.1 12.8 0.7 2.4 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein SGS PF05002.15 AAS50504.1 - 4.9e-28 97.1 0.7 1.6e-27 95.4 0.3 2.1 2 0 0 2 2 2 1 SGS domain CS PF04969.16 AAS50504.1 - 4.1e-14 53.3 0.6 7.3e-14 52.5 0.6 1.4 1 0 0 1 1 1 1 CS domain TPR_2 PF07719.17 AAS50504.1 - 0.0043 17.1 4.7 2.6 8.4 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS50504.1 - 0.11 13.4 6.2 4.3 8.4 0.1 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 AAS50504.1 - 0.12 12.2 1.9 1 9.3 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 AAS50504.1 - 0.19 11.6 1.3 0.43 10.4 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) TPR_12 PF13424.6 AAS50504.1 - 0.36 11.1 9.9 0.23 11.7 1.2 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50504.1 - 5.3 7.6 12.0 2.3 8.8 0.7 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS50504.1 - 7 6.9 8.7 14 5.9 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat PIN_6 PF17146.4 AAS50505.1 - 5.4e-31 106.9 0.0 1e-30 106.1 0.0 1.5 1 0 0 1 1 1 1 PIN domain of ribonuclease NOB1_Zn_bind PF08772.11 AAS50505.1 - 8e-24 83.6 0.1 1.3e-23 82.9 0.1 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like Prp31_C PF09785.9 AAS50505.1 - 0.088 13.7 5.4 0.59 11.1 1.9 2.6 2 0 0 2 2 2 0 Prp31 C terminal domain zinc_ribbon_9 PF14369.6 AAS50505.1 - 0.25 11.6 0.9 0.63 10.3 0.9 1.7 1 0 0 1 1 1 0 zinc-ribbon Flavoprotein PF02441.19 AAS50506.1 - 1.1e-51 174.7 0.1 1.6e-51 174.2 0.1 1.3 1 0 0 1 1 1 1 Flavoprotein RRN3 PF05327.11 AAS50506.1 - 0.15 10.6 18.2 0.25 9.9 18.2 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 AAS50506.1 - 0.21 9.8 31.6 0.27 9.4 31.6 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 AAS50506.1 - 1.7 7.3 9.5 3.2 6.4 9.5 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CIAPIN1 PF05093.13 AAS50507.1 - 5.9e-39 132.6 2.1 9.4e-39 132.0 2.1 1.3 1 0 0 1 1 1 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DRE2_N PF16803.5 AAS50507.1 - 6.3e-29 100.9 0.0 8.4e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Fe-S cluster assembly protein DRE2 N-terminus zf-U1 PF06220.12 AAS50508.1 - 6.7e-18 64.2 5.5 6.7e-18 64.2 5.5 1.7 2 0 0 2 2 2 1 U1 zinc finger DUF4043 PF13252.6 AAS50508.1 - 0.078 12.1 0.0 0.085 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4043) GTP_EFTU PF00009.27 AAS50509.1 - 6.6e-59 198.7 0.2 8.7e-59 198.3 0.2 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AAS50509.1 - 1.6e-27 96.0 0.0 3.1e-27 95.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AAS50509.1 - 6.9e-21 74.4 1.0 1.7e-20 73.2 1.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS50509.1 - 3.7e-05 23.8 0.0 7.6e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS50509.1 - 0.014 15.3 0.1 0.039 13.9 0.0 1.7 1 1 1 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 AAS50509.1 - 0.026 14.3 0.3 7.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation cobW PF02492.19 AAS50509.1 - 0.038 13.6 1.1 0.057 13.0 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain V-set_2 PF15910.5 AAS50509.1 - 0.083 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 ICOS V-set domain G_glu_transpept PF01019.21 AAS50510.1 - 7.1e-146 487.0 0.0 9e-146 486.6 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase DUF1708 PF08101.11 AAS50511.1 - 3.9e-120 401.9 0.2 3.4e-118 395.5 0.2 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1708) Cellulase PF00150.18 AAS50513.1 - 3.2e-11 43.2 0.8 7.5e-11 42.0 0.8 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) SNF2_N PF00176.23 AAS50514.1 - 2.7e-54 184.2 0.1 2.7e-54 184.2 0.1 2.3 3 0 0 3 3 3 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS50514.1 - 2.6e-15 56.7 0.1 6.9e-15 55.4 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS50514.1 - 3.8e-06 27.0 3.1 1.4e-05 25.2 0.0 3.4 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit zf-RING_UBOX PF13445.6 AAS50514.1 - 6e-06 26.2 0.8 1.5e-05 24.9 0.8 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AAS50514.1 - 3.2e-05 23.7 3.0 6.7e-05 22.7 3.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS50514.1 - 4.3e-05 23.4 2.8 9.5e-05 22.3 2.8 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 AAS50514.1 - 0.00022 21.0 1.2 0.00022 21.0 1.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS50514.1 - 0.00064 20.0 3.2 0.0017 18.7 3.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS50514.1 - 0.00094 19.0 1.6 0.00094 19.0 1.6 1.8 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS50514.1 - 0.07 13.0 8.1 0.03 14.2 4.3 2.3 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 UTP15_C PF09384.10 AAS50514.1 - 0.085 12.5 3.8 0.21 11.3 0.9 3.2 3 0 0 3 3 3 0 UTP15 C terminal DUF948 PF06103.11 AAS50514.1 - 0.11 12.8 1.1 0.5 10.7 1.1 2.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) zf-LSD1 PF06943.12 AAS50514.1 - 0.18 11.7 1.3 0.41 10.5 1.3 1.6 1 0 0 1 1 1 0 LSD1 zinc finger zf-C3HC4_4 PF15227.6 AAS50514.1 - 0.58 10.4 2.3 1.4 9.2 2.3 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Cornichon PF03311.14 AAS50516.1 - 2.7e-48 163.3 11.8 3e-48 163.1 11.8 1.0 1 0 0 1 1 1 1 Cornichon protein Bac_export_2 PF01312.19 AAS50516.1 - 1.8 7.7 5.4 2.3 7.4 5.4 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Erythro_esteras PF05139.14 AAS50517.1 - 0.014 15.2 5.5 0.02 14.7 5.5 1.1 1 0 0 1 1 1 0 Erythromycin esterase DUF2156 PF09924.9 AAS50517.1 - 0.043 12.8 0.5 0.059 12.4 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2156) RRM_1 PF00076.22 AAS50518.1 - 3e-39 132.7 0.0 2.2e-16 59.4 0.0 3.6 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS50518.1 - 0.0024 17.7 0.0 0.2 11.5 0.0 2.5 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_3 PF08777.11 AAS50518.1 - 0.0059 16.6 0.0 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 AAS50518.1 - 0.0069 16.4 0.0 0.082 12.9 0.0 2.3 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 AAS50518.1 - 0.082 13.0 0.0 0.42 10.8 0.0 2.2 2 0 0 2 2 2 0 RNA recognition motif NAD_binding_7 PF13241.6 AAS50519.1 - 1e-23 83.7 0.0 1.7e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 AAS50519.1 - 9e-11 41.3 0.1 1.8e-10 40.3 0.1 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein C-terminal Sirohm_synth_M PF14824.6 AAS50519.1 - 1.8e-10 40.1 0.2 3.3e-10 39.2 0.2 1.4 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central FA_desaturase PF00487.24 AAS50520.1 - 7.9e-20 71.8 21.8 7.9e-20 71.8 21.8 2.2 1 1 1 2 2 2 1 Fatty acid desaturase Cyt-b5 PF00173.28 AAS50520.1 - 6.8e-16 58.2 0.0 2.8e-15 56.2 0.0 2.0 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain CBS PF00571.28 AAS50521.1 - 5.2e-21 74.9 6.3 1.4e-05 25.4 0.0 5.3 5 0 0 5 5 5 5 CBS domain ASCH PF04266.14 AAS50521.1 - 0.12 12.9 0.1 3.9 8.1 0.0 2.7 3 1 1 4 4 4 0 ASCH domain Tir_receptor_C PF07489.11 AAS50521.1 - 0.15 12.0 4.0 0.3 11.1 4.0 1.5 1 1 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus UQ_con PF00179.26 AAS50523.1 - 4.2e-51 172.3 0.1 4.9e-51 172.1 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS50523.1 - 0.012 15.3 0.0 0.015 15.0 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B RWD PF05773.22 AAS50523.1 - 0.032 14.5 0.1 0.076 13.3 0.1 1.7 1 1 0 1 1 1 0 RWD domain UEV PF05743.13 AAS50523.1 - 0.064 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 UEV domain Leuk-A4-hydro_C PF09127.11 AAS50523.1 - 0.067 13.3 0.1 0.92 9.6 0.1 2.1 1 1 0 1 1 1 0 Leukotriene A4 hydrolase, C-terminal BCDHK_Adom3 PF10436.9 AAS50524.1 - 3.3e-30 105.0 1.2 5.4e-30 104.4 1.2 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AAS50524.1 - 1.5e-06 28.7 0.0 0.069 13.7 0.0 2.4 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HUN PF08729.10 AAS50525.1 - 1.2e-07 31.6 0.0 1.2e-07 31.6 0.0 2.3 2 0 0 2 2 2 1 HPC2 and ubinuclein domain TFIIA PF03153.13 AAS50525.1 - 0.00013 22.1 21.4 0.00019 21.6 21.4 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 AAS50525.1 - 1.7 7.9 8.7 3.2 7.0 8.7 1.4 1 0 0 1 1 1 0 NOA36 protein Kinetochor_Ybp2 PF08568.10 AAS50526.1 - 1.4e-152 509.5 0.0 1.7e-152 509.2 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin TetR_C_30 PF17939.1 AAS50526.1 - 0.075 13.3 1.0 0.98 9.7 0.1 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain APG12 PF04110.13 AAS50527.1 - 3.6e-27 94.6 0.0 5.3e-27 94.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 DASH_Duo1 PF08651.10 AAS50528.2 - 1.9e-23 82.0 0.3 1.9e-23 82.0 0.3 1.5 2 0 0 2 2 2 1 DASH complex subunit Duo1 DASH_Dad2 PF08654.10 AAS50528.2 - 0.0088 16.4 0.6 0.067 13.6 0.4 2.0 1 1 1 2 2 2 1 DASH complex subunit Dad2 FlgN PF05130.12 AAS50528.2 - 0.017 15.6 1.7 0.062 13.8 0.2 2.0 2 0 0 2 2 2 0 FlgN protein DUF4201 PF13870.6 AAS50528.2 - 0.024 14.4 1.4 0.032 14.0 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) JMY PF15871.5 AAS50528.2 - 0.024 13.9 0.1 0.032 13.5 0.1 1.2 1 0 0 1 1 1 0 Junction-mediating and -regulatory protein Allexi_40kDa PF05549.11 AAS50528.2 - 0.031 13.8 0.2 0.14 11.6 0.2 1.8 1 1 0 1 1 1 0 Allexivirus 40kDa protein DUF4618 PF15397.6 AAS50528.2 - 0.049 13.0 2.1 0.13 11.6 2.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) DASH_Dam1 PF08653.10 AAS50528.2 - 0.057 13.2 0.1 0.49 10.2 0.0 2.2 2 0 0 2 2 2 0 DASH complex subunit Dam1 DUF1690 PF07956.11 AAS50528.2 - 0.12 12.8 1.5 0.24 11.8 1.3 1.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) DUF4795 PF16043.5 AAS50528.2 - 0.2 11.2 2.2 1.9 8.0 2.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) SlyX PF04102.12 AAS50528.2 - 0.73 10.5 5.6 1 10.1 0.8 2.5 2 0 0 2 2 2 0 SlyX CPSase_L_D2 PF02786.17 AAS50529.2 - 8.8e-84 280.2 0.5 1.4e-83 279.6 0.5 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain PYC_OADA PF02436.18 AAS50529.2 - 4.3e-68 229.0 0.0 7.9e-68 228.1 0.0 1.5 1 0 0 1 1 1 1 Conserved carboxylase domain Biotin_carb_N PF00289.22 AAS50529.2 - 3.3e-38 130.6 0.0 6.9e-38 129.6 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AAS50529.2 - 1.6e-30 105.3 0.0 5.5e-30 103.6 0.0 2.0 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain HMGL-like PF00682.19 AAS50529.2 - 8.1e-24 84.6 0.0 1.9e-23 83.4 0.0 1.6 1 0 0 1 1 1 1 HMGL-like Biotin_lipoyl PF00364.22 AAS50529.2 - 1.2e-19 69.9 3.4 1.2e-19 69.9 3.4 2.3 3 0 0 3 3 2 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AAS50529.2 - 2.6e-08 33.7 0.0 5.2e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AAS50529.2 - 4.1e-08 33.0 0.1 9.9e-08 31.7 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 AAS50529.2 - 2.8e-07 30.3 2.6 0.0023 17.7 0.1 2.7 1 1 1 2 2 2 2 Biotin-lipoyl like ATP-grasp_3 PF02655.14 AAS50529.2 - 1.6e-05 25.0 0.2 5.9e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 ATP-grasp domain HlyD_D23 PF16576.5 AAS50529.2 - 4.4e-05 22.8 0.3 0.0043 16.3 0.1 2.4 1 1 1 2 2 2 1 Barrel-sandwich domain of CusB or HlyD membrane-fusion RimK PF08443.11 AAS50529.2 - 0.00044 19.9 0.1 0.0011 18.6 0.1 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.6 AAS50529.2 - 0.0018 17.9 0.0 0.0033 17.0 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 AAS50529.2 - 0.0024 17.2 0.0 0.0053 16.0 0.0 1.5 1 0 0 1 1 1 1 Sugar-transfer associated ATP-grasp HlyD_3 PF13437.6 AAS50529.2 - 0.0055 17.4 3.3 2.2 9.0 0.1 3.2 3 0 0 3 3 3 2 HlyD family secretion protein RnfC_N PF13375.6 AAS50529.2 - 0.03 14.3 2.3 0.22 11.5 0.7 2.8 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain NQRA PF05896.11 AAS50529.2 - 0.048 13.1 0.5 0.084 12.3 0.5 1.3 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) MF_alpha_N PF05436.11 AAS50530.1 - 4.9e-25 87.2 0.0 5.6e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus RET_CLD1 PF17756.1 AAS50530.1 - 0.15 12.3 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 RET Cadherin like domain 1 DEC-1_N PF04625.13 AAS50530.1 - 0.36 9.8 1.9 1.1 8.2 1.2 1.7 1 1 0 2 2 2 0 DEC-1 protein, N-terminal region Med31 PF05669.12 AAS50531.1 - 3.7e-26 90.9 0.9 4.5e-26 90.7 0.9 1.1 1 0 0 1 1 1 1 SOH1 Scs3p PF10261.9 AAS50532.1 - 4.5e-67 226.1 10.0 2.9e-65 220.2 10.0 2.0 1 1 0 1 1 1 1 Inositol phospholipid synthesis and fat-storage-inducing TM Acatn PF13000.7 AAS50533.2 - 1e-252 839.6 9.3 1.1e-252 839.4 9.3 1.0 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 UcrQ PF02939.16 AAS50533.2 - 0.15 12.0 0.1 0.68 9.9 0.0 2.1 2 0 0 2 2 2 0 UcrQ family Transket_pyr PF02779.24 AAS50534.1 - 6.3e-48 162.8 0.1 2.6e-47 160.8 0.0 1.8 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AAS50534.1 - 1.1e-37 128.7 0.1 2.2e-37 127.7 0.1 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain AMP-binding PF00501.28 AAS50535.1 - 1.4e-79 267.7 0.0 1.8e-79 267.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AAS50535.1 - 1.3e-17 64.6 0.6 7.3e-17 62.1 0.5 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain RELT PF12606.8 AAS50535.1 - 0.29 10.2 0.6 0.63 9.1 0.6 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 Tyr-DNA_phospho PF06087.12 AAS50536.1 - 4e-91 306.0 0.0 5.2e-91 305.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosyl-DNA phosphodiesterase PLDc_2 PF13091.6 AAS50536.1 - 0.0026 17.6 0.0 1.1 9.1 0.0 2.4 2 0 0 2 2 2 2 PLD-like domain MTHFR PF02219.17 AAS50537.2 - 3.7e-114 380.9 0.0 5e-114 380.5 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase Methyltransf_11 PF08241.12 AAS50538.1 - 0.025 15.2 0.0 0.063 13.9 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 AAS50538.1 - 0.043 13.7 0.0 0.087 12.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AAS50538.1 - 0.068 13.9 0.0 0.18 12.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain GIY-YIG PF01541.24 AAS50539.1 - 6.3e-12 45.6 0.0 1.3e-11 44.6 0.0 1.5 1 0 0 1 1 1 1 GIY-YIG catalytic domain zf-C2H2_2 PF12756.7 AAS50539.1 - 0.14 12.5 4.3 1.2 9.5 0.5 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) FANCL_C PF11793.8 AAS50539.1 - 0.5 10.6 6.8 0.65 10.2 5.6 1.8 1 1 0 1 1 1 0 FANCL C-terminal domain Glyco_hydro_31 PF01055.26 AAS50540.1 - 3.5e-124 415.4 0.3 5e-124 414.8 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Gal_mutarotas_2 PF13802.6 AAS50540.1 - 3.7e-24 84.8 0.1 1.6e-23 82.8 0.1 2.2 2 0 0 2 2 2 1 Galactose mutarotase-like DUF5110 PF17137.4 AAS50540.1 - 0.0013 19.0 2.1 0.0019 18.4 0.6 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF5110) GATA PF00320.27 AAS50541.1 - 1.6e-10 40.4 4.1 2.7e-10 39.7 4.1 1.4 1 0 0 1 1 1 1 GATA zinc finger Mon1 PF03164.14 AAS50542.2 - 1.1e-129 433.0 0.1 1.4e-129 432.7 0.1 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 DUF5353 PF17304.2 AAS50543.1 - 4.1 7.2 9.6 0.57 10.0 3.9 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5353) Ribosomal_S5 PF00333.20 AAS50544.1 - 5.7e-26 90.3 2.4 5.7e-26 90.3 2.4 2.4 3 0 0 3 3 3 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AAS50544.1 - 2.6e-22 78.0 0.0 4.6e-22 77.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Nab2 PF11517.8 AAS50545.1 - 9.3e-45 151.1 0.1 1.5e-44 150.4 0.1 1.3 1 0 0 1 1 1 1 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) Nab2p_Zf1 PF18260.1 AAS50545.1 - 8.8e-17 60.7 7.7 8.8e-17 60.7 7.7 3.6 4 0 0 4 4 4 1 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 zf-CCCH_2 PF14608.6 AAS50545.1 - 1.2e-14 54.1 70.7 3e-05 24.3 2.9 6.7 7 0 0 7 7 7 6 RNA-binding, Nab2-type zinc finger DUF2508 PF10704.9 AAS50545.1 - 0.11 12.6 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) HA2 PF04408.23 AAS50547.1 - 1.1e-22 80.3 0.0 2.9e-22 79.0 0.0 1.7 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AAS50547.1 - 1.6e-21 76.4 0.0 5.8e-21 74.6 0.0 2.0 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AAS50547.1 - 5.7e-13 49.2 0.0 1.5e-12 47.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AAS50547.1 - 9.4e-10 38.5 0.2 1.7e-09 37.7 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS50547.1 - 2e-06 28.1 0.2 5.7e-06 26.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 AAS50547.1 - 1.4e-05 24.9 0.1 3.6e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 AAS50547.1 - 0.00037 20.8 0.1 0.00073 19.9 0.1 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 AAS50547.1 - 0.0005 20.1 0.2 0.001 19.1 0.2 1.5 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_30 PF13604.6 AAS50547.1 - 0.00072 19.3 0.0 0.0014 18.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AAS50547.1 - 0.0041 17.7 0.0 0.05 14.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 AAS50547.1 - 0.04 13.2 0.0 0.061 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 AAS50547.1 - 0.04 13.4 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 AAS50547.1 - 0.086 11.9 0.0 0.16 11.0 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC1 PF03109.16 AAS50548.1 - 4e-34 117.3 0.0 9.8e-34 116.1 0.0 1.7 2 0 0 2 2 2 1 ABC1 family La PF05383.17 AAS50549.1 - 2.9e-15 56.1 0.1 4.9e-15 55.3 0.1 1.3 1 0 0 1 1 1 1 La domain Mannosyl_trans3 PF11051.8 AAS50550.1 - 2.8e-74 250.0 0.0 3.7e-74 249.5 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative XH PF03469.14 AAS50550.1 - 0.0033 17.3 0.6 0.0077 16.1 0.2 1.8 1 1 1 2 2 2 1 XH domain IPK PF03770.16 AAS50551.1 - 6.8e-50 169.7 0.4 2e-49 168.1 0.0 2.0 2 0 0 2 2 2 1 Inositol polyphosphate kinase DASH_Dad1 PF08649.10 AAS50552.1 - 8.5e-26 89.9 0.6 1.1e-25 89.6 0.6 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad1 PNP_phzG_C PF10590.9 AAS50553.1 - 5.6e-21 74.3 2.8 1.3e-20 73.2 2.8 1.7 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Putative_PNPOx PF01243.20 AAS50553.1 - 4.1e-14 52.5 0.0 6e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 AAS50553.1 - 0.052 14.2 0.1 0.11 13.1 0.1 1.7 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Wap1 PF16997.5 AAS50554.1 - 1.1e-115 386.9 2.6 1.3e-115 386.6 2.6 1.1 1 0 0 1 1 1 1 Wap1 domain WAPL PF07814.13 AAS50554.1 - 0.00014 20.8 3.3 0.011 14.5 0.4 2.2 2 0 0 2 2 2 2 Wings apart-like protein regulation of heterochromatin Sld5 PF05916.11 AAS50555.1 - 2.9e-08 34.1 0.2 5e-08 33.4 0.2 1.4 1 0 0 1 1 1 1 GINS complex protein PIF1 PF05970.14 AAS50555.1 - 0.0064 15.7 0.0 0.0096 15.1 0.0 1.2 1 0 0 1 1 1 1 PIF1-like helicase Methyltransf_10 PF05971.12 AAS50556.1 - 7.3e-40 137.2 0.0 9.2e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 AAS50556.1 - 0.00024 20.7 0.0 0.00042 19.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain CheR PF01739.18 AAS50556.1 - 0.021 14.3 0.0 0.036 13.6 0.0 1.3 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain Methyltransf_18 PF12847.7 AAS50556.1 - 0.03 14.3 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 AAS50556.1 - 0.066 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AAS50556.1 - 0.086 13.6 0.0 0.18 12.5 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AAS50557.1 - 2.6e-12 47.3 0.0 3.9e-11 43.5 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AAS50557.1 - 1.8e-11 44.0 0.0 2.9e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 AAS50557.1 - 6.6e-10 39.0 0.0 1.8e-09 37.6 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS50557.1 - 9.3e-09 35.8 0.0 5.3e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS50557.1 - 7.7e-08 32.3 0.0 1.4e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AAS50557.1 - 6.1e-07 29.0 0.0 8.4e-07 28.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_9 PF08003.11 AAS50557.1 - 2.3e-06 26.8 0.1 3.1e-06 26.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 AAS50557.1 - 1.7e-05 24.8 0.1 2.7e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AAS50557.1 - 5.6e-05 22.7 0.1 9.3e-05 22.0 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_16 PF10294.9 AAS50557.1 - 0.00031 20.5 0.2 0.00048 19.9 0.2 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_12 PF08242.12 AAS50557.1 - 0.00041 21.0 0.0 0.0011 19.7 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain FtsJ PF01728.19 AAS50557.1 - 0.00095 19.3 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_2 PF00891.18 AAS50557.1 - 0.0017 17.7 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase domain PCMT PF01135.19 AAS50557.1 - 0.0034 17.2 0.1 0.005 16.6 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TehB PF03848.14 AAS50557.1 - 0.0062 16.0 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Tellurite resistance protein TehB NNMT_PNMT_TEMT PF01234.17 AAS50557.1 - 0.016 14.4 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family Methyltransf_32 PF13679.6 AAS50557.1 - 0.027 14.5 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Met_10 PF02475.16 AAS50557.1 - 0.036 13.8 0.1 0.055 13.2 0.1 1.2 1 0 0 1 1 1 0 Met-10+ like-protein Methyltransf_24 PF13578.6 AAS50557.1 - 0.13 13.3 0.0 0.23 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Cons_hypoth95 PF03602.15 AAS50557.1 - 0.17 11.5 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_4 PF02390.17 AAS50557.1 - 0.24 10.8 0.5 0.4 10.1 0.1 1.6 2 0 0 2 2 2 0 Putative methyltransferase Ribosomal_L4 PF00573.22 AAS50558.1 - 1.6e-43 148.7 1.1 2.6e-43 148.0 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 AAS50558.1 - 1.2e-31 108.6 3.8 5e-31 106.6 0.7 2.6 2 1 1 3 3 3 1 60S ribosomal protein L4 C-terminal domain MFS_1 PF07690.16 AAS50559.1 - 1.8e-30 106.0 20.0 1.8e-30 106.0 20.0 1.4 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS50559.1 - 2e-23 83.0 22.3 4.4e-23 81.9 22.3 1.5 1 1 0 1 1 1 1 Sugar (and other) transporter Cation_ATPase_C PF00689.21 AAS50559.1 - 7.5 6.2 17.9 2.4e+03 -2.0 15.2 3.6 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus SET PF00856.28 AAS50560.1 - 6.3e-11 43.0 0.0 1.1e-06 29.2 0.0 2.2 2 0 0 2 2 2 2 SET domain MFS_1 PF07690.16 AAS50561.1 - 1.7e-27 96.3 17.6 2.8e-27 95.6 17.6 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS50561.1 - 1.7e-26 93.1 18.8 2.7e-25 89.2 18.8 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter Aldo_ket_red PF00248.21 AAS50562.2 - 9.2e-43 146.5 0.0 1.4e-40 139.3 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family MinC_N PF05209.13 AAS50562.2 - 0.19 11.7 0.0 0.64 10.0 0.0 1.9 2 1 1 3 3 3 0 Septum formation inhibitor MinC, N-terminal domain ATG2_CAD PF13329.6 AAS50563.2 - 2.9e-35 121.3 1.9 7.3e-35 120.0 0.4 2.6 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif ATG_C PF09333.11 AAS50563.2 - 1.9e-29 101.8 0.8 5.4e-29 100.4 0.5 2.0 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 AAS50563.2 - 0.029 14.1 0.1 0.32 10.7 0.0 2.6 2 0 0 2 2 2 0 Vacuolar-sorting-associated 13 protein C-terminal RhoGAP PF00620.27 AAS50564.2 - 4.6e-34 117.4 0.8 1.2e-33 116.1 0.1 2.1 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 AAS50564.2 - 5.6e-21 74.5 58.7 4.4e-08 33.2 5.5 4.6 4 0 0 4 4 4 4 LIM domain G6PD_C PF02781.16 AAS50565.1 - 1.6e-108 362.3 0.0 2.4e-108 361.7 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 AAS50565.1 - 4.3e-61 206.6 0.0 9.9e-61 205.4 0.0 1.6 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain Fe_hyd_lg_C PF02906.14 AAS50566.1 - 7.7e-67 225.5 0.0 1e-66 225.1 0.0 1.2 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Peptidase_C1_2 PF03051.15 AAS50567.1 - 8.1e-163 542.3 0.0 9.4e-163 542.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase C1-like family Peptidase_C1 PF00112.23 AAS50567.1 - 5.6e-09 36.4 0.0 0.00068 19.8 0.1 2.2 2 0 0 2 2 2 2 Papain family cysteine protease Peptidase_S8 PF00082.22 AAS50568.2 - 5.2e-36 124.4 0.1 7.7e-36 123.9 0.1 1.3 1 0 0 1 1 1 1 Subtilase family P_proprotein PF01483.20 AAS50568.2 - 2.2e-23 82.1 0.7 4.9e-23 81.0 0.7 1.6 1 0 0 1 1 1 1 Proprotein convertase P-domain Glycophorin_A PF01102.18 AAS50568.2 - 0.15 12.3 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Glycophorin A Med16 PF11635.8 AAS50569.2 - 5.5e-231 768.6 2.2 6.3e-231 768.4 2.2 1.0 1 0 0 1 1 1 1 Mediator complex subunit 16 SPAN-X PF07458.12 AAS50569.2 - 0.041 14.3 0.2 0.087 13.3 0.2 1.5 1 0 0 1 1 1 0 Sperm protein associated with nucleus, mapped to X chromosome TypeIII_RM_meth PF12564.8 AAS50569.2 - 0.21 11.7 1.0 2.1 8.5 0.0 2.7 2 0 0 2 2 2 0 Type III restriction/modification enzyme methylation subunit Globin PF00042.22 AAS50570.1 - 1.8e-05 25.2 0.0 4.9e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Globin Phycobilisome PF00502.19 AAS50571.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 Phycobilisome protein PDZ_5 PF17817.1 AAS50571.1 - 0.15 12.3 0.9 0.78 10.1 0.1 2.6 2 0 0 2 2 2 0 PDZ domain EXOSC1 PF10447.9 AAS50572.1 - 7.7e-41 139.1 0.1 1.9e-40 137.9 0.2 1.6 2 0 0 2 2 2 1 Exosome component EXOSC1/CSL4 CRAL_TRIO PF00650.20 AAS50573.1 - 5.9e-41 139.8 0.0 8.3e-41 139.4 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AAS50573.1 - 1.1e-16 60.8 0.5 2.6e-16 59.6 0.5 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain Elongin_A PF06881.11 AAS50574.1 - 6.7e-21 74.8 8.2 3.1e-19 69.5 8.2 2.3 1 1 0 1 1 1 1 RNA polymerase II transcription factor SIII (Elongin) subunit A MFA1_2 PF17317.2 AAS50575.1 - 6.3e-19 67.5 2.1 6.7e-19 67.4 2.1 1.0 1 0 0 1 1 1 1 Mating hormone A-factor 1&2 GST_C PF00043.25 AAS50576.1 - 3.2e-23 81.8 0.0 5.5e-23 81.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AAS50576.1 - 6.2e-20 71.3 0.0 1.8e-19 69.8 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 AAS50576.1 - 5.2e-11 42.8 0.0 2.3e-10 40.7 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 AAS50576.1 - 2.4e-10 40.5 0.0 2.3e-09 37.4 0.0 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 AAS50576.1 - 1.3e-05 25.3 0.0 2.5e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AAS50576.1 - 0.0098 15.9 0.0 0.027 14.5 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain DnaJ PF00226.31 AAS50577.1 - 4.3e-23 81.2 0.1 1.5e-22 79.5 0.1 2.0 1 0 0 1 1 1 1 DnaJ domain zf-C2H2_2 PF12756.7 AAS50577.1 - 2.6e-07 30.9 4.7 0.0093 16.3 0.9 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 AAS50577.1 - 4.4e-07 30.0 3.1 4.4e-07 30.0 3.1 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 AAS50577.1 - 0.00074 20.1 7.3 0.32 12.0 1.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AAS50577.1 - 0.0023 18.3 2.7 0.0023 18.3 2.7 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 AAS50577.1 - 0.0028 18.0 10.4 0.084 13.4 1.8 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AAS50577.1 - 0.023 14.7 6.8 0.71 9.9 0.6 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 AAS50577.1 - 0.03 14.0 2.9 0.11 12.1 0.3 2.6 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain TFIIS_C PF01096.18 AAS50577.1 - 0.11 12.3 0.9 0.44 10.5 0.0 2.4 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) AP-5_subunit_s1 PF15001.6 AAS50577.1 - 0.18 11.8 5.0 0.54 10.2 5.0 1.9 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 SID PF11778.8 AAS50578.2 - 4.2e-55 185.5 6.1 4.2e-55 185.5 6.1 3.1 2 1 0 2 2 2 1 Septation initiation Golgin_A5 PF09787.9 AAS50578.2 - 0.00053 19.6 26.1 0.00053 19.6 26.1 4.9 2 2 1 3 3 3 1 Golgin subfamily A member 5 GAS PF13851.6 AAS50578.2 - 0.0035 16.7 14.9 0.0035 16.7 14.9 6.1 2 2 3 5 5 5 2 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 AAS50578.2 - 0.031 14.7 87.9 0.54 10.7 16.1 5.7 1 1 5 6 6 6 0 Fez1 TolA_bind_tri PF16331.5 AAS50578.2 - 0.06 13.4 0.5 0.06 13.4 0.5 9.9 7 3 5 12 12 12 0 TolA binding protein trimerisation Ubiquitin_2 PF14560.6 AAS50578.2 - 0.083 13.4 7.0 3.2 8.3 0.6 3.8 3 0 0 3 3 3 0 Ubiquitin-like domain APP_N PF02177.16 AAS50578.2 - 0.3 11.5 3.1 0.72 10.3 0.7 2.8 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding AAA_13 PF13166.6 AAS50578.2 - 1.3 7.6 77.2 0.089 11.4 20.4 3.2 2 1 0 3 3 3 0 AAA domain POTRA PF07244.15 AAS50578.2 - 8.9 7.0 12.6 25 5.5 0.9 4.7 4 1 0 4 4 4 0 Surface antigen variable number repeat G-patch PF01585.23 AAS50579.1 - 1.4e-12 47.3 0.7 2.6e-12 46.4 0.7 1.5 1 0 0 1 1 1 1 G-patch domain R3H PF01424.22 AAS50579.1 - 0.00029 20.8 0.0 0.00075 19.4 0.0 1.8 1 0 0 1 1 1 1 R3H domain PAPA-1 PF04795.12 AAS50579.1 - 0.027 15.3 0.5 13 6.6 0.0 3.2 2 0 0 2 2 2 0 PAPA-1-like conserved region Peptidase_C54 PF03416.19 AAS50580.1 - 7.6e-86 287.9 0.0 1e-85 287.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C54 SseB_C PF14581.6 AAS50580.1 - 0.097 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 SseB protein C-terminal domain Ssu72 PF04722.13 AAS50581.1 - 5.8e-84 280.4 0.0 7e-84 280.1 0.0 1.1 1 0 0 1 1 1 1 Ssu72-like protein GDPD_2 PF13653.6 AAS50582.1 - 0.00054 20.3 2.8 0.0012 19.2 2.8 1.6 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family POP1 PF06978.11 AAS50584.1 - 5.5e-78 261.7 9.3 5.5e-78 261.7 9.3 1.7 2 0 0 2 2 2 1 Ribonucleases P/MRP protein subunit POP1 POPLD PF08170.12 AAS50584.1 - 2.6e-31 107.8 0.5 6.3e-31 106.6 0.5 1.7 1 0 0 1 1 1 1 POPLD (NUC188) domain DUF1389 PF07146.11 AAS50584.1 - 0.029 13.6 0.1 0.055 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1389) Adenylsucc_synt PF00709.21 AAS50585.2 - 8.2e-177 588.3 0.0 9.3e-177 588.1 0.0 1.0 1 0 0 1 1 1 1 Adenylosuccinate synthetase Glyco_transf_22 PF03901.17 AAS50586.1 - 1.7e-87 294.4 26.8 2.1e-87 294.0 26.8 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Hydrolase_6 PF13344.6 AAS50587.1 - 1.2e-27 95.9 0.0 3.4e-27 94.5 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AAS50587.1 - 2.7e-17 62.6 0.0 8.9e-17 60.9 0.0 1.8 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.26 AAS50587.1 - 2.2e-14 54.2 0.1 4.5e-14 53.2 0.1 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AAS50587.1 - 2.4e-07 31.0 0.0 0.00034 20.8 0.0 2.3 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase MgsA_C PF12002.8 AAS50588.1 - 1.9e-53 180.8 0.1 4e-53 179.8 0.1 1.5 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 AAS50588.1 - 1.4e-21 76.6 0.2 5.7e-21 74.6 0.0 2.2 2 0 0 2 2 1 1 AAA C-terminal domain AAA PF00004.29 AAS50588.1 - 2.2e-15 57.3 0.0 4.8e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AAS50588.1 - 2.8e-12 46.7 0.0 7.7e-12 45.2 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AAS50588.1 - 5.6e-08 33.3 0.1 6.5e-05 23.4 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 AAS50588.1 - 1e-06 28.8 0.2 3.3e-06 27.1 0.0 2.0 2 0 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AAS50588.1 - 3.3e-06 27.2 0.0 6.9e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS50588.1 - 7.4e-06 26.5 0.1 4e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AAS50588.1 - 1.6e-05 25.2 1.0 0.00086 19.6 0.2 3.2 2 1 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 AAS50588.1 - 0.00014 21.6 0.0 0.00086 19.0 0.0 2.0 1 1 0 1 1 1 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 AAS50588.1 - 0.00032 20.1 0.0 0.069 12.5 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AAS50588.1 - 0.00045 20.0 0.0 0.00077 19.2 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_30 PF13604.6 AAS50588.1 - 0.00075 19.3 0.0 0.0016 18.2 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 AAS50588.1 - 0.00094 19.3 0.0 0.0045 17.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 AAS50588.1 - 0.0015 18.9 0.2 0.61 10.4 0.1 2.5 1 1 1 2 2 2 2 AAA domain Bac_DnaA PF00308.18 AAS50588.1 - 0.0015 18.4 0.0 0.0024 17.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial dnaA protein DUF815 PF05673.13 AAS50588.1 - 0.002 17.4 0.0 0.0034 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TniB PF05621.11 AAS50588.1 - 0.0036 16.8 0.0 0.18 11.2 0.0 2.5 1 1 1 2 2 2 1 Bacterial TniB protein Viral_helicase1 PF01443.18 AAS50588.1 - 0.0036 17.1 0.0 0.02 14.6 0.0 2.0 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_3 PF07726.11 AAS50588.1 - 0.0053 16.6 0.0 0.012 15.5 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNF220 PF15926.5 AAS50588.1 - 0.008 15.8 0.2 0.013 15.1 0.2 1.3 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 ABC_tran PF00005.27 AAS50588.1 - 0.0094 16.5 0.2 0.036 14.6 0.0 2.1 2 1 1 3 3 2 1 ABC transporter AAA_24 PF13479.6 AAS50588.1 - 0.012 15.3 0.0 0.034 13.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AAS50588.1 - 0.014 15.5 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 AAS50588.1 - 0.019 15.3 0.0 0.074 13.5 0.0 2.1 2 0 0 2 2 1 0 RNA helicase Roc PF08477.13 AAS50588.1 - 0.019 15.2 0.0 0.087 13.0 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ResIII PF04851.15 AAS50588.1 - 0.042 13.8 0.1 0.96 9.4 0.1 2.2 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit zf-C2HC_2 PF13913.6 AAS50588.1 - 0.084 12.8 0.2 0.15 12.0 0.2 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type AAA_28 PF13521.6 AAS50588.1 - 0.092 13.0 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 AAS50588.1 - 0.15 11.6 0.1 9 5.8 0.0 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Hpt PF01627.23 AAS50589.1 - 1.3e-11 44.6 1.2 1.7e-11 44.2 1.2 1.2 1 0 0 1 1 1 1 Hpt domain PriC PF07445.12 AAS50589.1 - 0.29 11.0 3.1 1.6 8.6 0.7 2.4 2 1 0 2 2 2 0 Primosomal replication protein priC Metallophos PF00149.28 AAS50590.1 - 1.2e-06 29.2 0.0 2e-06 28.5 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AAS50590.1 - 5.4e-05 23.5 0.0 9.8e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain FBPase_2 PF06874.11 AAS50590.1 - 0.00037 18.9 0.1 0.077 11.3 0.0 2.0 1 1 1 2 2 2 2 Firmicute fructose-1,6-bisphosphatase Rap1-DNA-bind PF09197.10 AAS50591.1 - 3.6e-49 165.9 6.8 4.1e-45 152.8 0.8 3.7 3 0 0 3 3 3 2 Rap1, DNA-binding Rap1_C PF11626.8 AAS50591.1 - 4e-24 84.5 0.0 3.8e-22 78.2 0.0 3.0 3 0 0 3 3 3 1 TRF2-interacting telomeric protein/Rap1 - C terminal domain Myb_DNA-binding PF00249.31 AAS50591.1 - 2.7e-15 56.3 0.1 9.4e-12 44.9 0.0 4.4 4 0 0 4 4 4 1 Myb-like DNA-binding domain BRCT_2 PF16589.5 AAS50591.1 - 4.9e-09 36.5 0.2 5.7e-08 33.1 0.0 2.7 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-bind_2 PF08914.11 AAS50591.1 - 2.1e-08 34.2 0.6 9e-05 22.6 0.0 2.8 2 0 0 2 2 2 2 Rap1 Myb domain BRCT PF00533.26 AAS50591.1 - 0.00064 20.0 0.4 0.0028 18.0 0.0 2.3 3 0 0 3 3 3 1 BRCA1 C Terminus (BRCT) domain Myb_DNA-bind_6 PF13921.6 AAS50591.1 - 0.019 15.2 0.7 0.3 11.4 0.0 3.0 3 0 0 3 3 3 0 Myb-like DNA-binding domain SLIDE PF09111.10 AAS50591.1 - 0.14 12.2 0.0 0.14 12.2 0.0 2.7 4 0 0 4 4 4 0 SLIDE RabGAP-TBC PF00566.18 AAS50592.2 - 6.2e-30 104.5 25.5 1.1e-27 97.0 11.1 2.6 2 1 0 3 3 3 2 Rab-GTPase-TBC domain Nucleolin_bd PF16725.5 AAS50592.2 - 0.011 15.3 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 Nucleolin binding domain PAPA-1 PF04795.12 AAS50593.1 - 5.3e-20 72.0 7.8 5.3e-20 72.0 7.8 2.6 2 1 0 2 2 2 1 PAPA-1-like conserved region LIM_bind PF01803.16 AAS50594.1 - 7.3e-64 215.6 0.0 7.3e-64 215.6 0.0 1.9 2 0 0 2 2 2 1 LIM-domain binding protein Neugrin PF06413.11 AAS50596.1 - 1.2e-06 28.7 0.4 1.2e-06 28.7 0.4 1.6 2 0 0 2 2 2 1 Neugrin DUF1967 PF09269.11 AAS50596.1 - 0.00035 20.4 0.1 0.0011 18.8 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1967) Sigma70_r4 PF04545.16 AAS50596.1 - 0.0026 17.3 0.0 0.0063 16.0 0.0 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_11 PF08279.12 AAS50596.1 - 0.0069 16.3 0.1 0.036 14.0 0.0 2.3 2 0 0 2 2 2 1 HTH domain HTH_32 PF13565.6 AAS50596.1 - 0.01 16.4 2.1 0.014 16.0 0.0 2.3 2 1 0 2 2 2 0 Homeodomain-like domain HTH_Crp_2 PF13545.6 AAS50596.1 - 0.013 15.5 0.2 0.32 11.0 0.0 2.3 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain PP_kinase_N PF13089.6 AAS50596.1 - 0.031 14.6 0.2 0.076 13.4 0.1 1.8 1 1 0 1 1 1 0 Polyphosphate kinase N-terminal domain DUF3144 PF11342.8 AAS50596.1 - 0.049 13.9 0.1 0.089 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3144) HTH_7 PF02796.15 AAS50596.1 - 0.069 13.2 0.2 0.22 11.7 0.2 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase HSP70 PF00012.20 AAS50597.1 - 7.2e-233 774.1 8.0 8.1e-233 774.0 8.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS50597.1 - 1.1e-17 63.9 1.4 3.2e-16 59.1 0.8 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AAS50597.1 - 0.00011 22.1 0.0 0.0002 21.1 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AAS50597.1 - 0.8 10.2 9.4 2.4 8.6 0.1 3.8 3 3 0 3 3 3 0 Cell division protein FtsA KH_1 PF00013.29 AAS50598.1 - 0.0015 18.3 0.0 0.0044 16.8 0.0 1.8 2 0 0 2 2 2 1 KH domain Y_phosphatase PF00102.27 AAS50599.1 - 2.4e-54 184.4 0.2 1.9e-53 181.4 0.2 1.9 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 AAS50599.1 - 0.0051 16.8 0.0 0.0075 16.3 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AAS50599.1 - 0.0055 16.5 0.0 0.012 15.4 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 AAS50599.1 - 0.054 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Inositol hexakisphosphate FUSC_2 PF13515.6 AAS50600.2 - 3.9e-17 62.6 5.8 3.9e-17 62.6 5.8 2.5 2 0 0 2 2 2 1 Fusaric acid resistance protein-like TetR_C_11 PF16859.5 AAS50600.2 - 0.11 12.8 0.5 0.36 11.1 0.5 1.9 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DUF1270 PF06900.11 AAS50600.2 - 0.17 12.2 1.8 1.2 9.6 1.8 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1270) ArAE_2_N PF10337.9 AAS50600.2 - 2.4 7.1 10.3 2.2 7.2 3.7 3.1 3 1 0 3 3 3 0 Putative ER transporter, 6TM, N-terminal DUF2070 PF09843.9 AAS50600.2 - 4.3 5.5 9.4 0.038 12.3 0.6 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Ost4 PF10215.9 AAS50601.1 - 9.4e-16 57.3 2.0 1e-15 57.2 2.0 1.1 1 0 0 1 1 1 1 Oligosaccaryltransferase Mrx7 PF10906.8 AAS50602.1 - 9.2e-26 89.9 0.0 1.1e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 MIOREX complex component 7 DUF5372 PF17342.2 AAS50602.1 - 0.071 13.5 0.3 0.099 13.1 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5372) VID27 PF08553.10 AAS50603.1 - 5.3e-154 512.6 0.1 7.4e-154 512.1 0.1 1.1 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain VID27_N PF17748.1 AAS50603.1 - 1.9e-54 184.1 0.2 1.9e-54 184.1 0.2 1.9 2 0 0 2 2 2 1 VID27 N-terminal region VID27_PH PF17747.1 AAS50603.1 - 9.6e-22 77.3 0.2 4.4e-21 75.2 0.1 2.1 2 0 0 2 2 2 1 VID27 PH-like domain WD40 PF00400.32 AAS50603.1 - 0.15 13.0 0.0 8.7 7.4 0.0 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat RIO1 PF01163.22 AAS50605.1 - 6.1e-43 146.6 0.6 9.6e-43 146.0 0.6 1.3 1 0 0 1 1 1 1 RIO1 family Rio2_N PF09202.11 AAS50605.1 - 4.7e-31 106.8 0.2 1.4e-30 105.4 0.2 1.8 1 0 0 1 1 1 1 Rio2, N-terminal APH PF01636.23 AAS50605.1 - 1.5e-08 34.9 2.0 0.00019 21.5 0.0 2.7 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 AAS50605.1 - 0.00015 21.3 0.1 0.00034 20.0 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 AAS50605.1 - 0.00026 20.4 0.4 0.012 15.0 0.4 2.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AAS50605.1 - 0.012 14.4 0.7 0.014 14.2 0.0 1.4 2 0 0 2 2 2 0 Fungal protein kinase Astro_capsid_p PF12226.8 AAS50605.1 - 0.11 11.7 12.5 0.87 8.7 14.3 1.5 2 0 0 2 2 2 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 AAS50605.1 - 1.4 7.0 14.6 1.8 6.5 14.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 AAS50605.1 - 9.5 4.4 9.5 14 3.9 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein PH_18 PF18469.1 AAS50606.1 - 1.2e-46 158.2 0.2 5.4e-46 156.1 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Rtt106 PF08512.12 AAS50606.1 - 1.1e-30 105.9 0.7 2.7e-30 104.6 0.7 1.7 1 0 0 1 1 1 1 Histone chaperone Rttp106-like POB3_N PF17292.2 AAS50606.1 - 0.034 14.6 0.1 0.075 13.5 0.1 1.5 1 0 0 1 1 1 0 POB3-like N-terminal PH domain Cwf_Cwc_15 PF04889.12 AAS50606.1 - 1.6 8.4 14.2 2.4 7.8 14.2 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ArfGap PF01412.18 AAS50607.1 - 2.2e-34 118.0 0.2 5.5e-34 116.7 0.0 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf DUF2852 PF11014.8 AAS50607.1 - 0.069 13.3 0.3 14 5.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) adh_short_C2 PF13561.6 AAS50608.1 - 1.1e-42 146.3 2.6 1.3e-42 146.0 2.6 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AAS50608.1 - 1e-32 113.2 4.2 1.3e-32 112.8 4.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AAS50608.1 - 1e-11 45.0 4.0 1.6e-11 44.4 4.0 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS50608.1 - 0.18 11.2 0.6 0.24 10.8 0.6 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family PQQ_3 PF13570.6 AAS50608.1 - 0.46 11.0 2.4 5 7.7 0.0 2.8 2 1 0 2 2 2 0 PQQ-like domain SMK-1 PF04802.15 AAS50609.2 - 7.4e-58 195.5 6.0 7.4e-58 195.5 6.0 2.1 2 0 0 2 2 2 1 Component of IIS longevity pathway SMK-1 WH1 PF00568.23 AAS50609.2 - 0.0037 17.2 0.0 0.077 12.9 0.0 2.3 2 0 0 2 2 2 1 WH1 domain YjeF_N PF03853.15 AAS50610.1 - 3.6e-39 134.4 0.0 4.3e-39 134.1 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus DUF429 PF04250.13 AAS50610.1 - 0.11 12.2 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF429) PKcGMP_CC PF16808.5 AAS50611.2 - 0.023 14.6 6.5 0.023 14.6 6.5 2.5 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase T-box_assoc PF16176.5 AAS50611.2 - 0.025 14.7 1.2 0.37 10.9 0.0 2.3 2 1 0 2 2 2 0 T-box transcription factor-associated Septin PF00735.18 AAS50612.1 - 6.3e-74 248.8 2.1 1.4e-66 224.7 0.0 2.7 3 0 0 3 3 3 2 Septin AAA_24 PF13479.6 AAS50612.1 - 0.00049 19.9 0.0 0.0011 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain GTP_EFTU PF00009.27 AAS50612.1 - 0.00054 19.6 0.2 0.0021 17.6 0.0 2.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain AAA_33 PF13671.6 AAS50612.1 - 0.00058 20.0 0.1 0.002 18.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AAS50612.1 - 0.00067 19.9 0.0 0.0035 17.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS50612.1 - 0.00088 19.7 0.1 0.0057 17.1 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain MMR_HSR1 PF01926.23 AAS50612.1 - 0.0014 18.7 0.1 0.01 15.9 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 AAS50612.1 - 0.0025 17.4 0.0 0.0057 16.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 AAS50612.1 - 0.0028 17.6 0.0 0.0079 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 AAS50612.1 - 0.0042 17.5 0.2 0.015 15.7 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AIG1 PF04548.16 AAS50612.1 - 0.0044 16.4 1.3 0.029 13.7 0.0 2.4 2 0 0 2 2 2 1 AIG1 family AAA_18 PF13238.6 AAS50612.1 - 0.011 16.2 0.1 0.037 14.6 0.0 1.9 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 AAS50612.1 - 0.013 15.9 0.0 0.069 13.5 0.0 2.2 2 0 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 AAS50612.1 - 0.013 15.2 0.0 0.038 13.7 0.0 1.7 2 0 0 2 2 1 0 Sigma-54 interaction domain Roc PF08477.13 AAS50612.1 - 0.018 15.2 0.0 0.064 13.5 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Pox_A32 PF04665.12 AAS50612.1 - 0.025 14.1 0.0 0.059 12.8 0.0 1.6 1 0 0 1 1 1 0 Poxvirus A32 protein ABC_tran PF00005.27 AAS50612.1 - 0.028 14.9 0.7 0.52 10.8 0.0 2.6 3 0 0 3 3 2 0 ABC transporter RsgA_GTPase PF03193.16 AAS50612.1 - 0.032 14.1 0.8 0.12 12.3 0.0 2.3 3 0 0 3 3 3 0 RsgA GTPase TsaE PF02367.17 AAS50612.1 - 0.046 13.7 0.1 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FtsK_SpoIIIE PF01580.18 AAS50612.1 - 0.065 12.6 0.0 0.17 11.2 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family MobB PF03205.14 AAS50612.1 - 0.11 12.4 0.1 3.9 7.4 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Herpes_TK PF00693.18 AAS50612.1 - 0.12 11.6 0.1 2.2 7.5 0.1 2.2 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus AAA_25 PF13481.6 AAS50612.1 - 0.12 11.9 0.0 0.3 10.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AAS50612.1 - 0.23 11.6 2.2 0.41 10.8 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain TMCO5 PF14992.6 AAS50612.1 - 0.32 10.5 7.6 0.57 9.7 7.6 1.3 1 0 0 1 1 1 0 TMCO5 family FliD_N PF02465.18 AAS50612.1 - 0.38 11.5 10.9 0.29 11.8 2.4 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF737 PF05300.11 AAS50612.1 - 1.2 9.4 11.1 2.9 8.2 11.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF737) RRM_1 PF00076.22 AAS50613.1 - 4.2e-17 61.7 0.0 1.1e-15 57.2 0.0 2.8 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Membralin PF09746.9 AAS50613.1 - 1.5 7.8 8.8 2.3 7.2 8.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein PAT1 PF09770.9 AAS50613.1 - 6.8 4.8 54.5 0.27 9.5 48.0 1.9 2 0 0 2 2 2 0 Topoisomerase II-associated protein PAT1 RR_TM4-6 PF06459.12 AAS50613.1 - 8.6 6.1 21.2 14 5.4 21.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 AAS50613.1 - 8.7 5.0 29.7 18 4.0 29.7 1.5 1 0 0 1 1 1 0 Presenilin Lin-8 PF03353.15 AAS50613.1 - 9.3 5.7 30.8 32 3.9 30.8 2.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SUR7 PF06687.12 AAS50615.2 - 1.5e-36 126.1 9.9 1.9e-36 125.7 9.9 1.1 1 0 0 1 1 1 1 SUR7/PalI family CD99L2 PF12301.8 AAS50615.2 - 2.3 8.5 6.9 0.17 12.2 0.8 1.9 2 0 0 2 2 2 0 CD99 antigen like protein 2 Fig1 PF12351.8 AAS50615.2 - 2.8 7.8 7.4 5.3 6.9 7.4 1.4 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 CDC13_N PF16853.5 AAS50616.1 - 4.4e-69 232.2 0.5 1.8e-68 230.2 0.0 2.1 2 0 0 2 2 2 1 Cell division control protein 13 N-terminus Cdc13_OB4_dimer PF18233.1 AAS50616.1 - 1e-42 144.9 0.0 2.2e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 Cdc13 OB4 dimerization domain POT1 PF02765.17 AAS50616.1 - 1.8e-18 66.8 0.3 4.7e-18 65.4 0.1 1.9 2 0 0 2 2 2 1 Telomeric single stranded DNA binding POT1/CDC13 Creatininase PF02633.14 AAS50617.1 - 0.1 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Creatinine amidohydrolase Chitin_synth_1 PF01644.17 AAS50618.2 - 2.3e-68 229.3 0.0 4.1e-68 228.5 0.0 1.4 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_1N PF08407.11 AAS50618.2 - 3.8e-26 90.8 0.5 1.1e-25 89.4 0.5 1.8 1 0 0 1 1 1 1 Chitin synthase N-terminal Chitin_synth_2 PF03142.15 AAS50618.2 - 5.6e-17 61.6 9.9 8e-15 54.4 0.1 2.7 3 0 0 3 3 3 2 Chitin synthase Glyco_trans_2_3 PF13632.6 AAS50618.2 - 5.1e-08 33.1 7.9 5.1e-08 33.1 7.9 2.5 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AAS50618.2 - 0.007 16.2 0.0 2.3 8.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AAS50618.2 - 0.028 14.3 0.0 0.069 13.0 0.0 1.6 2 0 0 2 2 2 0 Glycosyltransferase like family 2 FixH PF05751.11 AAS50618.2 - 0.15 12.1 0.7 0.31 11.0 0.7 1.5 1 0 0 1 1 1 0 FixH Tyr_Deacylase PF02580.16 AAS50619.2 - 4.7e-52 176.3 0.0 5.2e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase GATase_4 PF13230.6 AAS50620.1 - 1.5e-16 60.1 0.0 2.4e-14 52.9 0.0 2.1 2 0 0 2 2 2 2 Glutamine amidotransferases class-II GATase_6 PF13522.6 AAS50620.1 - 3.2e-11 43.6 0.0 5.5e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AAS50620.1 - 0.039 13.9 0.0 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Glutamine amidotransferase domain Arm PF00514.23 AAS50621.1 - 2.7e-88 287.6 17.7 1.6e-13 50.2 0.2 8.6 9 0 0 9 9 9 8 Armadillo/beta-catenin-like repeat IBB PF01749.20 AAS50621.1 - 5.7e-28 97.2 8.3 4e-27 94.5 8.9 2.2 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 AAS50621.1 - 2.3e-21 75.1 2.6 3.8e-20 71.2 4.1 2.3 3 0 0 3 3 3 1 Atypical Arm repeat HEAT_EZ PF13513.6 AAS50621.1 - 4.2e-21 75.0 2.0 3.5e-05 24.2 0.0 7.1 6 2 2 8 8 8 5 HEAT-like repeat HEAT_2 PF13646.6 AAS50621.1 - 1.9e-15 57.0 0.3 0.00026 21.3 0.0 5.2 2 2 4 6 6 6 5 HEAT repeats HEAT PF02985.22 AAS50621.1 - 1e-13 50.3 0.1 0.027 14.7 0.0 6.6 7 0 0 7 7 6 2 HEAT repeat RICTOR_V PF14668.6 AAS50621.1 - 9.7e-07 28.9 2.2 0.051 13.8 0.0 5.2 3 3 3 6 6 6 1 Rapamycin-insensitive companion of mTOR, domain 5 Arm_2 PF04826.13 AAS50621.1 - 5.9e-06 25.9 0.8 3.1 7.2 0.1 4.2 2 1 2 4 4 4 4 Armadillo-like V-ATPase_H_C PF11698.8 AAS50621.1 - 1.2e-05 25.4 1.1 0.45 10.7 0.0 4.4 4 2 1 5 5 5 3 V-ATPase subunit H Adaptin_N PF01602.20 AAS50621.1 - 2.4e-05 23.1 0.7 0.00033 19.4 0.4 2.7 1 1 1 2 2 2 1 Adaptin N terminal region NopRA1 PF16201.5 AAS50621.1 - 0.00038 20.1 0.0 0.77 9.3 0.0 4.7 2 1 2 4 4 4 1 Nucleolar pre-ribosomal-associated protein 1 Atx10homo_assoc PF09759.9 AAS50621.1 - 0.0016 18.4 0.0 1 9.4 0.0 3.9 4 0 0 4 4 4 1 Spinocerebellar ataxia type 10 protein domain FAST_1 PF06743.15 AAS50621.1 - 0.032 14.2 0.8 2.8 8.0 0.0 3.3 4 0 0 4 4 4 0 FAST kinase-like protein, subdomain 1 O-FucT PF10250.9 AAS50621.1 - 0.13 12.0 0.8 0.24 11.0 0.8 1.4 1 0 0 1 1 1 0 GDP-fucose protein O-fucosyltransferase PUL PF08324.11 AAS50621.1 - 0.58 9.3 4.7 8.5 5.5 0.0 3.2 2 1 1 3 3 3 0 PUL domain Tim17 PF02466.19 AAS50623.1 - 1.5e-38 131.6 4.4 1.8e-38 131.3 4.4 1.1 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family JAB PF01398.21 AAS50625.1 - 1.2e-25 89.8 0.0 2e-25 89.1 0.0 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 AAS50625.1 - 0.00017 21.4 0.0 0.00037 20.2 0.0 1.5 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 AAS50625.1 - 0.00037 20.6 0.0 0.00078 19.5 0.0 1.7 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0172) UCH PF00443.29 AAS50626.1 - 5.4e-50 170.3 0.5 8.9e-50 169.6 0.5 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS50626.1 - 9.2e-17 61.6 0.2 2.6e-15 56.8 0.2 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Ribosomal_L11_N PF03946.14 AAS50627.1 - 6.7e-27 93.1 0.2 1.1e-26 92.5 0.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AAS50627.1 - 3.7e-25 88.2 0.1 5.6e-25 87.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Pkinase PF00069.25 AAS50628.3 - 9.2e-47 159.6 0.0 1.4e-46 159.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50628.3 - 1.1e-22 80.6 0.0 2.6e-22 79.4 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 AAS50628.3 - 0.021 14.4 0.0 0.049 13.2 0.0 1.6 1 0 0 1 1 1 0 RIO1 family Haspin_kinase PF12330.8 AAS50628.3 - 0.029 13.3 0.1 0.063 12.2 0.1 1.6 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 AAS50628.3 - 0.19 11.6 0.0 0.32 10.9 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family RRM_1 PF00076.22 AAS50629.1 - 1.3e-05 24.9 0.0 2.6e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS50629.1 - 0.05 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif FAM76 PF16046.5 AAS50629.1 - 1.5 8.1 8.9 4.6 6.5 6.6 2.0 1 1 0 1 1 1 0 FAM76 protein WD40 PF00400.32 AAS50630.1 - 0.0059 17.4 0.4 29 5.8 0.0 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 AAS50630.1 - 0.019 13.7 0.0 0.18 10.5 0.0 2.3 2 1 0 2 2 2 0 Nup133 N terminal like DUF1513 PF07433.11 AAS50630.1 - 0.032 13.3 0.2 0.068 12.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1513) HPS3_N PF14761.6 AAS50630.1 - 0.04 13.4 0.2 0.79 9.2 0.0 2.5 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 AbfS_sensor PF18225.1 AAS50630.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Sensor histidine kinase (AbfS) sensor domain adh_short PF00106.25 AAS50631.2 - 1.1e-09 38.0 0.0 7.5e-09 35.3 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 AAS50631.2 - 7.9e-08 32.4 0.0 2e-07 31.1 0.0 1.6 2 0 0 2 2 2 1 KR domain adh_short_C2 PF13561.6 AAS50631.2 - 7.7e-06 25.6 0.0 2.6e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Ras PF00071.22 AAS50632.1 - 9.4e-48 161.9 0.0 1.2e-47 161.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS50632.1 - 1.1e-20 74.0 0.0 3.9e-20 72.3 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS50632.1 - 2.7e-07 30.2 0.0 5.5e-07 29.2 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AAS50632.1 - 0.00025 20.7 0.0 0.00083 18.9 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AAS50632.1 - 0.061 13.4 0.0 0.093 12.8 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_S3_C PF00189.20 AAS50633.2 - 1.5e-23 83.1 0.1 7.9e-23 80.8 0.1 2.0 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AAS50633.2 - 5.9e-12 45.2 0.0 2.3e-11 43.3 0.1 1.9 2 0 0 2 2 2 1 KH domain SHR3_chaperone PF08229.11 AAS50634.1 - 8.7e-74 246.6 1.2 1.1e-73 246.3 1.2 1.0 1 0 0 1 1 1 1 ER membrane protein SH3 DUF3139 PF11337.8 AAS50634.1 - 0.059 14.0 0.5 2 9.1 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) MlaE PF02405.16 AAS50634.1 - 7 6.3 9.6 2 8.0 0.4 2.6 1 1 2 3 3 3 0 Permease MlaE Ribosomal_L22 PF00237.19 AAS50635.1 - 1.6e-19 70.0 0.0 2.6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e CD34_antigen PF06365.12 AAS50636.2 - 0.022 14.4 0.0 2.8 7.4 0.0 2.3 2 0 0 2 2 2 0 CD34/Podocalyxin family COX14 PF14880.6 AAS50636.2 - 0.059 13.2 0.2 0.11 12.3 0.2 1.5 1 0 0 1 1 1 0 Cytochrome oxidase c assembly RRM_1 PF00076.22 AAS50637.2 - 6.1e-26 90.0 0.3 4.8e-16 58.3 0.0 3.8 3 1 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AAS50637.2 - 0.0014 18.6 0.0 0.0078 16.2 0.0 2.0 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif HTH_19 PF12844.7 AAS50637.2 - 0.034 14.2 1.0 0.067 13.2 1.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Peptidase_S49_N PF08496.10 AAS50637.2 - 0.083 13.0 2.6 0.1 12.6 2.0 1.4 1 1 0 1 1 1 0 Peptidase family S49 N-terminal RRM_7 PF16367.5 AAS50637.2 - 0.13 12.4 0.0 1.4 9.1 0.0 2.5 2 2 0 2 2 2 0 RNA recognition motif AMPK1_CBM PF16561.5 AAS50638.2 - 6.6e-13 48.7 0.1 1.1e-12 48.0 0.1 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase YkpC PF17447.2 AAS50638.2 - 1.1 10.3 24.6 43 5.3 1.1 7.3 5 0 0 5 5 5 0 Uncharacterized YkpC-like Ubie_methyltran PF01209.18 AAS50639.1 - 2.1e-97 325.1 0.0 2.4e-97 324.9 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 AAS50639.1 - 7.3e-13 49.1 0.0 1.3e-12 48.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS50639.1 - 1.1e-10 42.0 0.0 2.1e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS50639.1 - 1.4e-10 41.2 0.0 2.1e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS50639.1 - 4.5e-09 37.0 0.0 7.8e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS50639.1 - 7.2e-06 25.9 0.0 1.1e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AAS50639.1 - 0.044 13.8 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_28 PF02636.17 AAS50639.1 - 0.059 13.0 0.0 0.091 12.4 0.0 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_8 PF05148.15 AAS50639.1 - 0.11 12.3 0.0 0.44 10.4 0.0 1.9 1 1 1 2 2 2 0 Hypothetical methyltransferase Bul1_N PF04425.12 AAS50640.1 - 1.9e-164 547.7 0.2 1.9e-164 547.7 0.2 1.6 2 0 0 2 2 2 1 Bul1 N terminus Bul1_C PF04426.12 AAS50640.1 - 3e-111 371.2 6.5 6.2e-111 370.2 6.5 1.6 1 0 0 1 1 1 1 Bul1 C terminus CTK3_C PF12350.8 AAS50641.1 - 3.5e-16 59.1 2.8 6.9e-16 58.2 2.8 1.4 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 C-terminus CTK3 PF12243.8 AAS50641.1 - 0.00016 21.6 0.0 0.00042 20.3 0.0 1.7 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 ubiquitin PF00240.23 AAS50642.1 - 1.2e-21 76.2 0.1 1.8e-21 75.7 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AAS50642.1 - 3.5e-11 42.8 0.0 5.3e-11 42.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UBA PF00627.31 AAS50642.1 - 3e-06 27.0 0.2 8.5e-06 25.6 0.2 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Rad60-SLD_2 PF13881.6 AAS50642.1 - 0.00015 21.8 0.1 0.00041 20.4 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AAS50642.1 - 0.00098 19.5 0.0 0.002 18.6 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin-like domain HOIP-UBA PF16678.5 AAS50642.1 - 0.033 14.2 0.0 0.061 13.3 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair GerD PF17898.1 AAS50642.1 - 0.053 13.5 1.4 0.091 12.7 1.4 1.3 1 0 0 1 1 1 0 Spore germination GerD central core domain Ubiquitin_4 PF18036.1 AAS50642.1 - 0.057 13.5 0.2 12 6.0 0.0 2.2 1 1 1 2 2 2 0 Ubiquitin-like domain TBK1_ULD PF18396.1 AAS50642.1 - 0.077 12.9 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain YukD PF08817.10 AAS50642.1 - 0.088 13.5 0.1 0.44 11.3 0.0 2.3 3 0 0 3 3 2 0 WXG100 protein secretion system (Wss), protein YukD DUF2407 PF10302.9 AAS50642.1 - 0.1 13.2 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain TAF8_C PF10406.9 AAS50643.1 - 4e-20 72.1 1.6 1.7e-19 70.1 1.6 2.2 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term Bromo_TP PF07524.13 AAS50643.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated NIF PF03031.18 AAS50644.2 - 2.4e-22 79.4 0.0 5.7e-22 78.2 0.0 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 AAS50644.2 - 6.3e-13 48.9 0.0 1.6e-12 47.6 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AAS50644.2 - 4.4e-07 29.7 0.0 9.9e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 AAS50644.2 - 0.0019 18.0 0.0 1.2 9.1 0.0 2.6 2 0 0 2 2 2 2 Biotin-lipoyl like Biotin_lipoyl PF00364.22 AAS50644.2 - 0.035 13.9 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 Biotin-requiring enzyme HlyD_D23 PF16576.5 AAS50644.2 - 0.054 12.7 0.1 1.9 7.6 0.0 2.3 1 1 1 2 2 2 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion HlyD_3 PF13437.6 AAS50644.2 - 0.065 13.9 0.2 2.4 8.9 0.1 2.9 3 0 0 3 3 3 0 HlyD family secretion protein PGM_PMM_I PF02878.16 AAS50645.1 - 1.9e-35 121.6 0.0 5e-35 120.2 0.0 1.7 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 AAS50645.1 - 3.4e-22 79.0 0.0 7.5e-22 77.9 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 AAS50645.1 - 4e-17 62.4 0.1 1.2e-16 60.9 0.0 1.8 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 AAS50645.1 - 6.9e-05 23.0 0.0 0.00018 21.6 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DUF4434 PF14488.6 AAS50645.1 - 0.82 9.7 3.4 6 6.8 0.7 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4434) S-methyl_trans PF02574.16 AAS50646.1 - 1.6e-56 192.1 0.0 1.8e-56 191.9 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Anp1 PF03452.14 AAS50647.2 - 1.7e-116 388.3 0.0 2.2e-116 387.9 0.0 1.1 1 0 0 1 1 1 1 Anp1 Asp PF00026.23 AAS50648.1 - 3.3e-39 135.2 0.0 5.6e-39 134.4 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 AAS50648.1 - 1.7e-05 24.7 0.0 0.00013 21.8 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal TAXi_N PF14543.6 AAS50648.1 - 0.0004 20.7 4.2 0.002 18.4 0.9 3.1 3 1 0 3 3 3 1 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AAS50648.1 - 0.012 16.3 0.3 11 6.8 0.0 3.1 2 1 0 2 2 2 0 Aspartyl protease Nab6_mRNP_bdg PF10567.9 AAS50649.2 - 3.6e-69 233.7 10.0 3.6e-69 233.7 10.0 2.5 2 1 0 2 2 2 1 RNA-recognition motif RRM PF10378.9 AAS50649.2 - 2.1e-18 65.7 11.8 2.1e-18 65.7 11.8 3.2 2 0 0 2 2 2 1 Putative RRM domain RRM_1 PF00076.22 AAS50649.2 - 2.1e-06 27.5 0.0 0.055 13.3 0.0 3.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Fungal_trans PF04082.18 AAS50650.2 - 9.2e-44 149.5 0.6 1.5e-43 148.8 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS50650.2 - 1.9e-10 40.7 13.0 3e-10 40.0 13.0 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PIG-L PF02585.17 AAS50651.1 - 2.4e-21 76.7 0.0 3.7e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase ATP13 PF12921.7 AAS50652.2 - 8.3e-07 28.9 0.0 1.7e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATPase expression Exo_endo_phos PF03372.23 AAS50653.1 - 2.2e-33 115.7 0.0 4.3e-33 114.8 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ku PF02735.16 AAS50654.1 - 1.5e-25 90.1 0.0 2.5e-25 89.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AAS50654.1 - 4.9e-08 33.0 0.0 1.5e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 Ku70/Ku80 N-terminal alpha/beta domain Ku_C PF03730.14 AAS50654.1 - 0.031 15.0 1.2 0.081 13.6 0.3 2.0 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Ribosomal_S27e PF01667.17 AAS50654.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S27 AA_permease_2 PF13520.6 AAS50655.2 - 3.5e-64 217.2 57.2 4.3e-64 216.9 57.2 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AAS50655.2 - 3.6e-17 62.1 50.7 4.9e-17 61.7 50.7 1.1 1 0 0 1 1 1 1 Amino acid permease Ribosomal_L7Ae PF01248.26 AAS50656.1 - 7.2e-28 96.2 0.3 1.1e-27 95.6 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Citrate_synt PF00285.21 AAS50656.1 - 0.014 14.5 0.1 0.02 14.0 0.1 1.1 1 0 0 1 1 1 0 Citrate synthase, C-terminal domain NUC173 PF08161.12 AAS50657.1 - 0.0079 15.9 0.0 0.032 13.9 0.0 1.9 2 0 0 2 2 2 1 NUC173 domain Adaptin_N PF01602.20 AAS50659.1 - 9.9e-100 334.6 16.8 2e-99 333.5 16.8 1.4 1 0 0 1 1 1 1 Adaptin N terminal region Coatamer_beta_C PF07718.12 AAS50659.1 - 2e-51 173.6 0.1 5.3e-51 172.2 0.1 1.8 1 0 0 1 1 1 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 AAS50659.1 - 4.8e-51 172.1 0.0 1.3e-50 170.6 0.0 1.8 1 0 0 1 1 1 1 Coatomer beta subunit appendage platform Cnd1 PF12717.7 AAS50659.1 - 5.1e-08 33.1 15.1 4.2e-06 26.9 0.3 4.5 3 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AAS50659.1 - 2.8e-07 30.9 7.6 0.18 12.2 0.1 4.7 2 1 1 4 4 4 3 HEAT repeats Vac14_Fab1_bd PF12755.7 AAS50659.1 - 0.09 13.4 1.1 0.44 11.2 0.2 2.7 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region AP4E_app_platf PF14807.6 AAS50659.1 - 1 9.8 4.2 2.1 8.7 0.0 3.6 4 1 1 5 5 5 0 Adaptin AP4 complex epsilon appendage platform Ribosomal_L5_C PF00673.21 AAS50660.2 - 2.5e-26 91.7 0.0 6.5e-26 90.3 0.0 1.7 2 0 0 2 2 2 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AAS50660.2 - 2.9e-15 56.3 0.0 5.7e-15 55.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 GLE1 PF07817.13 AAS50661.1 - 6e-88 294.3 0.0 8.6e-88 293.8 0.0 1.2 1 0 0 1 1 1 1 GLE1-like protein Asp-B-Hydro_N PF05279.11 AAS50661.1 - 0.43 10.6 25.9 0.66 10.0 25.9 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region BAF1_ABF1 PF04684.13 AAS50661.1 - 0.97 8.4 12.7 1.3 8.0 12.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor V_ATPase_I PF01496.19 AAS50661.1 - 1.5 6.6 8.2 2.3 6.1 8.2 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 AAS50661.1 - 2.2 8.4 5.5 3.8 7.6 5.5 1.5 1 0 0 1 1 1 0 DDHD domain DUF1501 PF07394.12 AAS50661.1 - 6 5.8 10.9 8.5 5.3 10.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Flavokinase PF01687.17 AAS50662.1 - 1.4e-30 105.9 0.0 1.8e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Riboflavin kinase TPR_19 PF14559.6 AAS50663.2 - 0.0095 16.4 1.6 0.026 15.0 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS50663.2 - 0.011 16.5 0.1 10 7.3 0.0 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat Porphobil_deam PF01379.20 AAS50664.1 - 3.6e-73 245.4 0.0 4.6e-73 245.1 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 AAS50664.1 - 6.6e-23 80.9 0.4 1.2e-22 80.1 0.4 1.4 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain eRF1_2 PF03464.15 AAS50664.1 - 0.16 12.3 0.0 0.38 11.1 0.0 1.6 1 0 0 1 1 1 0 eRF1 domain 2 Aconitase PF00330.20 AAS50665.2 - 5.7e-108 361.9 0.3 5.3e-107 358.7 0.3 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AAS50665.2 - 2e-28 99.3 0.0 3.5e-28 98.6 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Reticulon PF02453.17 AAS50666.1 - 6.5e-36 123.7 1.5 9.3e-36 123.2 1.5 1.2 1 0 0 1 1 1 1 Reticulon PepSY_TM PF03929.16 AAS50666.1 - 0.03 14.0 0.0 0.044 13.4 0.0 1.3 1 0 0 1 1 1 0 PepSY-associated TM region HisKA_3 PF07730.13 AAS50666.1 - 0.18 12.3 0.3 18 5.9 0.1 2.3 2 0 0 2 2 2 0 Histidine kinase Aminotran_1_2 PF00155.21 AAS50667.1 - 2.3e-70 237.6 0.0 3e-70 237.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AAS50667.1 - 6.4e-08 31.5 0.0 1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 AAS50667.1 - 4.3e-05 23.0 0.3 0.0001 21.7 0.3 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 AAS50667.1 - 0.00018 20.6 0.0 0.00027 20.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Preseq_ALAS PF09029.10 AAS50667.1 - 0.0022 18.5 0.4 0.0058 17.1 0.4 1.7 1 0 0 1 1 1 1 5-aminolevulinate synthase presequence DegT_DnrJ_EryC1 PF01041.17 AAS50667.1 - 0.027 13.8 0.2 0.28 10.4 0.2 2.1 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Wtap PF17098.5 AAS50668.2 - 2.2e-08 34.2 14.2 2.2e-08 34.2 14.2 1.8 2 0 0 2 2 2 1 WTAP/Mum2p family BLOC1_2 PF10046.9 AAS50668.2 - 0.042 14.1 9.5 2.8 8.3 0.6 3.5 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 WD40_alt PF14077.6 AAS50668.2 - 0.18 11.7 2.4 3.9 7.4 0.4 2.6 2 0 0 2 2 2 0 Alternative WD40 repeat motif FapA PF03961.13 AAS50668.2 - 10 4.6 14.6 6.5 5.2 2.0 2.3 1 1 0 2 2 2 0 Flagellar Assembly Protein A DAHP_synth_1 PF00793.20 AAS50669.1 - 9.3e-103 342.8 0.0 1.2e-102 342.5 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family Cellulase PF00150.18 AAS50670.1 - 6.8e-10 38.8 3.2 6.8e-10 38.8 3.2 2.0 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) PRP1_N PF06424.12 AAS50671.1 - 1.7e-25 90.1 4.6 5.4e-25 88.5 4.6 1.9 1 1 0 1 1 1 1 PRP1 splicing factor, N-terminal TPR_14 PF13428.6 AAS50671.1 - 2.1e-24 84.1 4.0 0.0027 18.4 0.0 10.3 8 3 3 11 11 10 6 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50671.1 - 5.7e-19 68.4 0.1 1.3e-07 32.0 0.0 7.1 5 2 1 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 AAS50671.1 - 3.2e-08 34.1 0.5 0.086 13.5 0.0 5.0 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50671.1 - 4.6e-06 26.3 0.0 0.086 13.0 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat SPO22 PF08631.10 AAS50671.1 - 1.9e-05 24.3 7.0 0.81 9.1 0.0 4.6 2 1 2 4 4 4 3 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 AAS50671.1 - 2.9e-05 24.3 0.3 0.12 12.6 0.0 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 AAS50671.1 - 0.00019 21.5 0.1 35 5.1 0.0 5.8 6 0 0 6 6 5 0 Tetratricopeptide repeat Suf PF05843.14 AAS50671.1 - 0.00056 20.0 0.5 0.74 9.7 0.0 4.1 2 2 2 5 5 5 1 Suppressor of forked protein (Suf) TPR_8 PF13181.6 AAS50671.1 - 0.0012 18.9 1.1 2.2 8.7 0.0 4.7 5 0 0 5 5 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS50671.1 - 0.0015 18.7 0.1 0.25 11.6 0.0 3.5 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 NatB_MDM20 PF09797.9 AAS50671.1 - 0.0046 15.9 0.0 0.014 14.4 0.0 1.7 1 0 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit TPR_1 PF00515.28 AAS50671.1 - 0.013 15.3 0.0 0.076 12.9 0.0 2.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 AAS50671.1 - 0.033 14.3 3.1 15 5.8 0.0 4.1 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 AAS50671.1 - 0.036 13.8 0.0 10 5.9 0.0 3.6 3 1 1 4 4 3 0 TPR repeat TPR_20 PF14561.6 AAS50671.1 - 0.046 14.0 0.1 0.36 11.2 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat NARP1 PF12569.8 AAS50671.1 - 0.053 12.4 5.2 2.7 6.8 0.0 4.2 3 1 3 6 6 6 0 NMDA receptor-regulated protein 1 Endonuc-BglII PF09195.11 AAS50671.1 - 0.22 11.3 0.8 0.89 9.4 0.1 2.2 2 0 0 2 2 2 0 Restriction endonuclease BglII Fungal_trans_2 PF11951.8 AAS50672.1 - 7.9e-23 80.9 0.2 1.3e-22 80.1 0.2 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS50672.1 - 3.6e-06 27.0 13.0 6.4e-06 26.2 13.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SGL PF08450.12 AAS50673.1 - 5.2e-69 232.6 0.0 6.3e-69 232.3 0.0 1.1 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 AAS50673.1 - 0.00073 19.7 0.0 1 9.6 0.0 3.1 3 0 0 3 3 3 2 Arylesterase CX9C PF16860.5 AAS50674.1 - 2.1e-28 98.1 16.4 3.1e-19 68.7 4.9 2.1 2 0 0 2 2 2 2 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, CHCH PF06747.13 AAS50674.1 - 5.4e-05 23.2 12.6 0.023 14.8 3.6 2.6 2 1 0 2 2 2 2 CHCH domain UPF0203 PF05254.12 AAS50674.1 - 0.00036 20.7 7.2 0.022 15.0 1.3 2.7 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0203) COX6B PF02297.17 AAS50674.1 - 0.0016 18.6 9.5 0.0088 16.3 1.3 2.1 1 1 1 2 2 2 2 Cytochrome oxidase c subunit VIb Cmc1 PF08583.10 AAS50674.1 - 0.022 14.8 13.9 0.034 14.1 3.9 2.3 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like UCR_hinge PF02320.16 AAS50674.1 - 0.6 10.3 12.2 0.22 11.8 2.4 2.7 1 1 0 2 2 2 0 Ubiquinol-cytochrome C reductase hinge protein Pet191_N PF10203.9 AAS50674.1 - 1.1 9.6 14.0 0.23 11.8 4.0 2.9 1 1 2 3 3 3 0 Cytochrome c oxidase assembly protein PET191 WD40 PF00400.32 AAS50675.2 - 2.3e-08 34.5 9.0 0.21 12.5 0.0 4.9 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50675.2 - 0.0059 16.9 0.0 0.38 11.1 0.0 3.3 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1752 PF08550.10 AAS50676.1 - 3.9e-13 49.0 1.9 1.3e-12 47.3 1.9 2.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) ANAPC_CDC26 PF10471.9 AAS50676.1 - 8.2 7.3 15.3 8.1 7.4 7.8 3.8 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Pex2_Pex12 PF04757.14 AAS50677.1 - 1.3e-22 80.6 11.5 2.2e-22 79.8 11.5 1.3 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_2 PF13923.6 AAS50677.1 - 1.7 8.6 8.5 23 4.9 9.4 2.2 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Vps54 PF07928.12 AAS50678.2 - 0.00033 21.1 1.3 0.0025 18.3 0.6 2.7 2 0 0 2 2 2 1 Vps54-like protein Imm3 PF14425.6 AAS50678.2 - 0.65 10.1 5.6 0.078 13.0 0.4 2.2 2 0 0 2 2 2 0 Immunity protein Imm3 Myb_DNA-binding PF00249.31 AAS50679.1 - 2.6e-23 82.0 16.4 2.1e-11 43.8 1.0 5.5 5 1 0 5 5 5 4 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS50679.1 - 1.7e-19 69.8 15.8 3e-15 56.2 2.0 4.3 3 1 1 4 4 4 2 Myb-like DNA-binding domain RskA PF10099.9 AAS50679.1 - 0.0097 16.2 0.2 0.015 15.6 0.2 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA CdiI PF07262.11 AAS50679.1 - 0.011 15.5 0.6 0.13 12.0 0.4 2.6 1 1 0 1 1 1 0 CDI immunity protein DUF1376 PF07120.11 AAS50679.1 - 0.039 14.3 0.2 0.17 12.3 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) Myb_DNA-bind_4 PF13837.6 AAS50679.1 - 0.14 12.5 10.7 0.97 9.9 1.2 4.6 3 1 1 4 4 4 0 Myb/SANT-like DNA-binding domain MADF_DNA_bdg PF10545.9 AAS50679.1 - 0.45 10.9 11.6 16 5.9 0.5 4.5 2 2 2 4 4 4 0 Alcohol dehydrogenase transcription factor Myb/SANT-like MMtag PF10159.9 AAS50679.1 - 0.61 10.4 4.9 23 5.4 1.1 3.3 2 1 0 2 2 2 0 Multiple myeloma tumor-associated Ribosomal_S17_N PF16205.5 AAS50680.1 - 1.2e-31 108.9 0.7 2.4e-31 107.9 0.7 1.5 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 AAS50680.1 - 2.1e-27 95.0 2.2 4.7e-27 93.9 2.2 1.6 1 0 0 1 1 1 1 Ribosomal protein S17 DUF922 PF06037.11 AAS50680.1 - 0.1 12.4 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF922) ADH_zinc_N PF00107.26 AAS50681.1 - 2.8e-24 85.5 0.0 5.2e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AAS50681.1 - 3.4e-09 37.9 0.0 6.3e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AAS50681.1 - 4.5e-09 36.2 0.0 2.5e-08 33.7 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.6 AAS50681.1 - 0.028 14.3 0.2 0.047 13.6 0.2 1.4 1 0 0 1 1 1 0 NAD(P)H-binding adh_short PF00106.25 AAS50681.1 - 0.12 11.8 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 short chain dehydrogenase RmlD_sub_bind PF04321.17 AAS50681.1 - 0.19 10.8 0.1 0.27 10.3 0.1 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain LST1 PF05083.13 AAS50682.2 - 0.092 13.0 0.1 0.27 11.6 0.1 1.8 1 0 0 1 1 1 0 LST-1 protein NTS_2 PF15448.6 AAS50682.2 - 0.18 12.3 3.1 0.33 11.4 0.4 2.9 3 0 0 3 3 3 0 N-terminal segments of P. falciparum erythrocyte membrane protein tRNA-synt_2b PF00587.25 AAS50683.1 - 6e-33 114.3 0.0 1.2e-32 113.3 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AAS50683.1 - 2.3e-24 85.7 9.9 2.3e-24 85.7 9.9 2.0 2 0 0 2 2 2 1 Seryl-tRNA synthetase N-terminal domain TPR_MLP1_2 PF07926.12 AAS50683.1 - 0.0041 17.2 6.3 0.0086 16.1 6.3 1.5 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF4164 PF13747.6 AAS50683.1 - 0.05 13.9 3.1 0.11 12.8 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) HemX PF04375.14 AAS50683.1 - 0.18 11.1 6.2 0.058 12.7 3.6 1.4 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase PCRF PF03462.18 AAS50683.1 - 0.68 9.8 5.8 1.9 8.3 5.5 1.8 2 0 0 2 2 2 0 PCRF domain Mgm101p PF06420.12 AAS50685.1 - 4.9e-85 283.3 0.0 7.1e-85 282.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial genome maintenance MGM101 PMT PF02366.18 AAS50686.2 - 7.9e-82 274.5 21.4 1.4e-81 273.7 21.4 1.4 1 0 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AAS50686.2 - 7.4e-62 208.5 4.6 7.4e-62 208.5 4.6 3.2 2 1 0 3 3 3 2 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AAS50686.2 - 1.5e-23 83.6 0.2 2.6e-23 82.8 0.2 1.3 1 0 0 1 1 1 1 MIR domain DUF4743 PF15916.5 AAS50687.2 - 8.7e-12 45.1 0.1 1.3e-11 44.5 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4743) NUDIX PF00293.28 AAS50687.2 - 1.5e-06 28.2 0.0 2.8e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain YnfE PF17452.2 AAS50687.2 - 0.08 13.3 0.1 0.21 11.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized YnfE-like DHHA2 PF02833.14 AAS50688.1 - 5.2e-24 85.0 0.4 2.9e-23 82.6 0.2 2.0 2 0 0 2 2 2 1 DHHA2 domain DHH PF01368.20 AAS50688.1 - 3e-10 40.2 0.1 8.5e-10 38.8 0.0 1.7 1 1 1 2 2 2 1 DHH family SAM_Ste50p PF09235.10 AAS50688.1 - 0.031 14.5 0.0 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 Ste50p, sterile alpha motif HECT_2 PF09814.9 AAS50689.1 - 1.2e-61 208.7 0.0 1.4e-61 208.5 0.0 1.0 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zinc_ribbon_4 PF13717.6 AAS50689.1 - 0.2 11.6 0.7 5.3 7.0 0.1 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Homoserine_dh PF00742.19 AAS50691.1 - 5.2e-53 179.5 0.0 6.6e-53 179.2 0.0 1.1 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 AAS50691.1 - 1.9e-19 70.4 0.0 3.1e-19 69.8 0.0 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain IML1 PF12257.8 AAS50692.2 - 7.4e-98 327.2 0.1 1.2e-97 326.5 0.1 1.3 1 0 0 1 1 1 1 Vacuolar membrane-associated protein Iml1 DEP PF00610.21 AAS50692.2 - 7.3e-25 86.8 0.1 2.2e-24 85.3 0.1 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) VWA_2 PF13519.6 AAS50693.1 - 7.8e-21 74.7 0.8 5.3e-20 72.1 0.0 2.5 2 1 2 4 4 4 1 von Willebrand factor type A domain Ssl1 PF04056.14 AAS50693.1 - 6.8e-07 29.3 0.2 9.9e-07 28.8 0.2 1.2 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 AAS50693.1 - 2e-05 24.9 0.3 2.8e-05 24.5 0.3 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 AAS50693.1 - 0.024 14.6 1.1 0.075 13.0 1.1 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF1887 PF09002.11 AAS50693.1 - 0.033 12.9 0.1 0.048 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1887) NIR_SIR PF01077.22 AAS50694.2 - 9e-52 174.8 0.0 2.8e-48 163.4 0.0 2.4 2 0 0 2 2 2 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 AAS50694.2 - 2.3e-27 94.6 0.0 1.6e-12 47.1 0.0 2.8 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Flavodoxin_1 PF00258.25 AAS50694.2 - 6e-26 91.4 0.0 1.2e-25 90.4 0.0 1.5 1 0 0 1 1 1 1 Flavodoxin THOC7 PF05615.13 AAS50694.2 - 0.15 12.3 0.1 0.76 10.1 0.1 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 Chalcone_2 PF16035.5 AAS50695.1 - 2e-63 213.9 0.0 2.4e-63 213.6 0.0 1.1 1 0 0 1 1 1 1 Chalcone isomerase like Chalcone_3 PF16036.5 AAS50695.1 - 0.0071 16.5 0.6 2.4 8.3 0.8 2.3 1 1 1 2 2 2 2 Chalcone isomerase-like Tti2 PF10521.9 AAS50696.1 - 8.5e-61 206.0 1.1 1.1e-60 205.6 1.1 1.1 1 0 0 1 1 1 1 Tti2 family zf-Tim10_DDP PF02953.15 AAS50697.1 - 1.1e-19 69.8 3.3 1.3e-19 69.6 3.3 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger DUF4580 PF15162.6 AAS50697.1 - 0.017 14.7 0.1 0.021 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) SlyX PF04102.12 AAS50698.2 - 0.021 15.4 0.5 0.021 15.4 0.5 2.3 2 0 0 2 2 2 0 SlyX Rx_N PF18052.1 AAS50698.2 - 0.3 11.4 5.0 18 5.7 0.2 3.1 2 1 1 3 3 3 0 Rx N-terminal domain RIX1 PF08167.12 AAS50699.2 - 3.7e-46 157.2 0.2 2e-45 154.9 0.0 2.2 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis ParcG PF10274.9 AAS50699.2 - 0.00087 19.5 0.5 0.27 11.4 0.1 2.6 2 0 0 2 2 2 2 Parkin co-regulated protein NUC130_3NT PF08158.12 AAS50699.2 - 0.061 13.7 2.0 21 5.5 0.0 4.4 3 2 1 4 4 4 0 NUC130/3NT domain TMF_TATA_bd PF12325.8 AAS50700.1 - 7.1e-30 103.6 11.6 7.1e-30 103.6 11.6 5.7 2 1 4 6 6 6 2 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 AAS50700.1 - 8.4e-08 32.1 22.1 8.4e-08 32.1 22.1 7.8 4 3 4 8 8 8 5 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 AAS50700.1 - 0.014 15.4 11.8 0.014 15.4 11.8 4.6 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 AAS50700.1 - 0.83 10.1 19.8 3 8.3 1.0 5.5 4 2 1 5 5 5 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 AAS50700.1 - 3.3 8.2 14.3 3.1 8.3 2.5 4.3 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Leu_zip PF15294.6 AAS50700.1 - 3.4 7.1 58.1 0.23 11.0 8.1 4.3 2 1 2 4 4 4 0 Leucine zipper APG6_N PF17675.1 AAS50700.1 - 5.8 7.4 79.9 0.22 12.1 15.5 4.5 2 1 1 4 4 4 0 Apg6 coiled-coil region LPP PF04728.13 AAS50700.1 - 9.5 6.7 14.8 46 4.5 0.1 5.3 4 0 0 4 4 4 0 Lipoprotein leucine-zipper Pribosyltran PF00156.27 AAS50701.2 - 2.5e-10 40.1 0.0 3.8e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Gmx_para_CXXCG PF09535.10 AAS50702.2 - 0.14 11.4 0.0 0.24 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) Utp12 PF04003.12 AAS50702.2 - 0.15 12.4 0.3 0.25 11.7 0.3 1.4 1 0 0 1 1 1 0 Dip2/Utp12 Family IBN_N PF03810.19 AAS50703.2 - 1.1e-14 54.1 0.0 8.8e-13 48.0 0.0 3.6 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cse1 PF08506.10 AAS50703.2 - 7.1e-05 21.8 0.9 0.00025 20.0 0.0 2.4 3 0 0 3 3 3 1 Cse1 MDM31_MDM32 PF08118.11 AAS50705.1 - 5.3e-224 744.7 1.7 8.6e-223 740.8 1.7 1.9 1 1 0 1 1 1 1 Yeast mitochondrial distribution and morphology (MDM) proteins GDPD_2 PF13653.6 AAS50705.1 - 0.12 12.8 0.1 2.3 8.8 0.0 2.6 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family PCI PF01399.27 AAS50706.1 - 1.7e-06 28.4 0.5 1.7e-05 25.3 0.0 2.7 2 0 0 2 2 2 1 PCI domain DUF2064 PF09837.9 AAS50706.1 - 0.044 13.6 0.5 0.12 12.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) GLTP PF08718.11 AAS50707.1 - 2.1e-48 164.4 0.0 3.9e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Glycolipid transfer protein (GLTP) Recep_L_domain PF01030.24 AAS50708.2 - 1.4e-09 38.0 9.9 0.027 14.6 0.1 4.9 1 1 3 4 4 4 3 Receptor L domain LRR_5 PF13306.6 AAS50708.2 - 0.00096 19.1 5.0 0.0072 16.3 0.5 2.8 1 1 1 2 2 2 1 BspA type Leucine rich repeat region (6 copies) Ecm33 PF12454.8 AAS50708.2 - 0.016 15.3 2.5 0.063 13.4 2.5 2.1 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein RL11D PF11088.8 AAS50708.2 - 0.047 14.0 0.3 0.14 12.5 0.3 1.8 1 0 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 LRR_4 PF12799.7 AAS50708.2 - 0.049 14.1 10.3 0.77 10.3 0.1 4.3 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AAS50708.2 - 0.3 10.9 6.2 5.2 6.9 0.1 3.5 3 0 0 3 3 3 0 Leucine rich repeat SAM_decarbox PF01536.16 AAS50710.1 - 4.2e-128 427.3 0.0 4.8e-128 427.1 0.0 1.0 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase RRM_1 PF00076.22 AAS50712.1 - 2.3e-26 91.4 0.4 7.3e-15 54.6 0.1 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AAS50712.1 - 2.1e-05 24.1 0.0 0.0024 17.5 0.0 2.1 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS50712.1 - 0.068 13.3 0.2 17 5.6 0.0 2.7 2 2 0 2 2 2 0 RNA recognition motif zf-RING_2 PF13639.6 AAS50713.2 - 4.2e-07 30.2 7.3 1.1e-06 28.9 7.3 1.8 1 0 0 1 1 1 1 Ring finger domain FANCL_C PF11793.8 AAS50713.2 - 1.4e-05 25.2 3.3 3.5e-05 23.9 3.3 1.7 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 AAS50713.2 - 0.00013 22.2 6.0 0.00029 21.1 6.0 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AAS50713.2 - 0.00086 19.3 1.3 0.0022 18.0 1.3 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 AAS50713.2 - 0.043 14.1 6.3 0.095 13.0 6.3 1.6 1 0 0 1 1 1 0 RING-like domain zf-C3HC4 PF00097.25 AAS50713.2 - 0.065 13.1 7.1 0.15 11.9 7.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AAS50713.2 - 0.1 12.2 4.0 0.22 11.2 4.0 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_2 PF13923.6 AAS50713.2 - 0.15 12.0 6.6 0.36 10.7 6.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS50713.2 - 0.5 10.3 4.8 1.9 8.4 4.8 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RINGv PF12906.7 AAS50713.2 - 1.2 9.3 9.0 0.25 11.5 5.1 2.0 2 0 0 2 2 2 0 RING-variant domain Forkhead_N PF08430.12 AAS50714.1 - 0.16 12.6 11.3 0.23 12.1 11.3 1.2 1 0 0 1 1 1 0 Forkhead N-terminal region Aldose_epim PF01263.20 AAS50715.1 - 4e-52 177.4 0.4 4.9e-52 177.1 0.4 1.0 1 0 0 1 1 1 1 Aldose 1-epimerase Pkinase PF00069.25 AAS50716.1 - 6e-37 127.4 0.0 1e-36 126.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50716.1 - 8e-20 71.2 0.0 5.1e-19 68.6 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase AP_endonuc_2 PF01261.24 AAS50717.1 - 2.3e-31 108.9 0.1 3.4e-31 108.4 0.1 1.3 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel XPG_N PF00752.17 AAS50719.2 - 4.1e-35 120.3 0.0 8.1e-35 119.3 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AAS50719.2 - 4.7e-29 100.6 0.1 1.2e-28 99.3 0.0 1.7 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 AAS50719.2 - 6.3e-06 26.7 2.9 2.6e-05 24.7 0.0 2.6 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 AAS50719.2 - 0.0091 16.6 0.0 0.03 14.9 0.0 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.7 AAS50719.2 - 0.11 12.6 0.0 0.32 11.1 0.0 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix motif BAF1_ABF1 PF04684.13 AAS50720.2 - 6.7e-155 517.3 43.6 2.1e-76 258.2 1.9 4.0 1 1 3 4 4 4 4 BAF1 / ABF1 chromatin reorganising factor Mcm10 PF09332.11 AAS50720.2 - 0.0099 15.3 2.4 0.015 14.7 2.4 1.3 1 0 0 1 1 1 1 Mcm10 replication factor DBD_Tnp_Mut PF03108.15 AAS50720.2 - 0.014 15.3 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 MuDR family transposase Spore_II_R PF09551.10 AAS50720.2 - 2.8 8.4 5.3 3.8 8.0 0.0 2.9 3 1 1 4 4 4 0 Stage II sporulation protein R (spore_II_R) mRNA_stabil PF13929.6 AAS50721.2 - 2.9e-86 289.0 2.4 4.7e-86 288.3 2.4 1.3 1 0 0 1 1 1 1 mRNA stabilisation RsfS PF02410.15 AAS50721.2 - 7.1e-14 52.0 0.0 1.7e-13 50.8 0.0 1.7 1 0 0 1 1 1 1 Ribosomal silencing factor during starvation KTI12 PF08433.10 AAS50722.2 - 3.8e-103 344.7 0.4 4.3e-103 344.5 0.4 1.0 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_33 PF13671.6 AAS50722.2 - 1.4e-05 25.3 0.0 4e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain APS_kinase PF01583.20 AAS50722.2 - 0.00098 19.0 0.0 0.002 18.0 0.0 1.5 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.6 AAS50722.2 - 0.004 17.7 0.1 0.014 15.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AAS50722.2 - 0.0084 16.4 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS50722.2 - 0.013 15.9 0.4 0.087 13.2 0.4 2.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AAS50722.2 - 0.031 14.5 0.3 0.19 12.0 0.3 2.5 1 1 0 1 1 1 0 AAA domain Miff PF05644.11 AAS50722.2 - 0.057 13.0 0.6 0.096 12.3 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff AAA_14 PF13173.6 AAS50722.2 - 0.076 13.0 0.0 0.28 11.2 0.0 2.0 2 1 1 3 3 3 0 AAA domain UPF0029 PF01205.19 AAS50722.2 - 0.12 12.7 0.6 0.46 10.8 0.1 2.1 2 1 0 2 2 2 0 Uncharacterized protein family UPF0029 MMR_HSR1 PF01926.23 AAS50723.1 - 5.6e-12 45.8 0.0 9.4e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS50723.1 - 5.6e-06 26.4 0.0 3.1e-05 23.9 0.0 2.0 1 1 0 1 1 1 1 RsgA GTPase FeoB_N PF02421.18 AAS50723.1 - 0.00015 21.4 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B AAA_18 PF13238.6 AAS50723.1 - 0.0013 19.3 0.0 0.089 13.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AAS50723.1 - 0.01 14.9 0.1 0.015 14.3 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AAS50723.1 - 0.026 14.9 0.5 0.092 13.1 0.2 1.9 1 1 1 2 2 2 0 AAA ATPase domain Glycos_trans_3N PF02885.17 AAS50723.1 - 0.33 10.8 1.9 4.8 7.1 0.1 2.4 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain Hap4_Hap_bind PF10297.9 AAS50724.2 - 2.1e-08 34.0 8.4 4.6e-08 32.9 8.4 1.6 1 0 0 1 1 1 1 Minimal binding motif of Hap4 for binding to Hap2/3/5 IFP_35_N PF07334.13 AAS50724.2 - 0.0057 16.7 0.1 0.017 15.2 0.1 1.8 1 0 0 1 1 1 1 Interferon-induced 35 kDa protein (IFP 35) N-terminus Rootletin PF15035.6 AAS50724.2 - 0.021 14.9 1.6 0.026 14.5 0.1 1.8 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Mto2_bdg PF12808.7 AAS50724.2 - 0.055 13.8 2.9 0.17 12.2 2.9 1.8 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region SseC PF04888.12 AAS50724.2 - 0.25 10.9 0.1 0.39 10.3 0.1 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DivIC PF04977.15 AAS50724.2 - 0.39 10.5 2.3 0.81 9.5 2.3 1.4 1 0 0 1 1 1 0 Septum formation initiator Drc1-Sld2 PF11719.8 AAS50726.1 - 7.3e-46 157.6 16.8 6.4e-29 101.8 8.6 2.1 1 1 1 2 2 2 2 DNA replication and checkpoint protein SPT6_acidic PF14632.6 AAS50726.1 - 0.16 12.6 10.0 0.1 13.2 1.3 2.4 1 1 1 2 2 2 0 Acidic N-terminal SPT6 UTP15_C PF09384.10 AAS50727.1 - 1.4e-45 154.6 0.3 2.2e-45 153.9 0.3 1.3 1 0 0 1 1 1 1 UTP15 C terminal WD40 PF00400.32 AAS50727.1 - 1.6e-14 54.0 3.9 0.15 13.0 0.1 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50727.1 - 3.7e-06 27.2 0.0 0.026 14.8 0.0 4.2 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ANAPC4_WD40 PF12894.7 AAS50728.1 - 6.3e-15 55.2 5.0 5.1e-06 26.7 0.0 7.9 6 2 2 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS50728.1 - 1.4e-14 54.2 21.1 0.33 11.9 0.4 10.8 10 1 1 11 11 11 4 WD domain, G-beta repeat WD40_like PF17005.5 AAS50728.1 - 0.00019 20.9 0.0 0.0024 17.2 0.0 2.4 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 AAS50728.1 - 0.0012 17.6 0.2 0.33 9.6 0.1 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 RAB3GAP2_N PF14655.6 AAS50728.1 - 0.026 13.8 0.0 0.082 12.2 0.0 1.8 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus CRC_subunit PF08624.10 AAS50729.1 - 2.2e-53 180.3 0.0 3.7e-53 179.6 0.0 1.4 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit Alpha-mann_mid PF09261.11 AAS50729.1 - 0.17 12.0 0.0 0.36 11.0 0.0 1.5 1 0 0 1 1 1 0 Alpha mannosidase middle domain SDA1 PF05285.12 AAS50729.1 - 0.24 10.8 12.3 0.31 10.4 12.3 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 AAS50729.1 - 1 7.6 9.2 1.3 7.2 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 AAS50729.1 - 3.2 7.0 23.3 4.4 6.5 23.3 1.2 1 0 0 1 1 1 0 NOA36 protein Mpp10 PF04006.12 AAS50729.1 - 6.7 5.0 15.0 9 4.6 15.0 1.1 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 AAS50729.1 - 6.9 4.8 16.0 8.6 4.4 16.0 1.1 1 0 0 1 1 1 0 Nop14-like family Peptidase_M41 PF01434.18 AAS50730.2 - 1.5e-63 214.1 1.6 3.9e-63 212.7 0.0 2.1 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 AAS50730.2 - 6e-42 143.2 0.0 2.2e-41 141.4 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS50730.2 - 2.6e-13 49.5 0.1 2.6e-13 49.5 0.1 2.7 3 0 0 3 3 3 1 AAA+ lid domain FtsH_ext PF06480.15 AAS50730.2 - 1.4e-07 31.8 0.0 3.2e-07 30.7 0.0 1.6 1 0 0 1 1 1 1 FtsH Extracellular AAA_5 PF07728.14 AAS50730.2 - 0.0005 20.1 0.0 0.0018 18.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS50730.2 - 0.0012 19.3 1.5 0.032 14.6 0.2 3.3 2 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AAS50730.2 - 0.0032 17.2 0.0 0.0084 15.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AAS50730.2 - 0.0038 17.4 0.2 0.015 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 AAS50730.2 - 0.0043 16.3 0.0 0.009 15.3 0.0 1.5 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_17 PF13207.6 AAS50730.2 - 0.0055 17.1 0.0 0.0055 17.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain IstB_IS21 PF01695.17 AAS50730.2 - 0.014 15.1 0.0 0.062 13.0 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_22 PF13401.6 AAS50730.2 - 0.021 15.1 1.8 0.84 9.9 0.1 3.2 3 0 0 3 3 3 0 AAA domain DUF2452 PF10504.9 AAS50730.2 - 0.062 12.8 1.4 0.13 11.7 1.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) AAA_33 PF13671.6 AAS50730.2 - 0.1 12.7 0.5 0.78 9.9 0.0 2.7 2 1 0 2 2 2 0 AAA domain LPD22 PF18834.1 AAS50730.2 - 0.27 11.5 3.2 0.69 10.2 3.2 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 22 AAA_28 PF13521.6 AAS50730.2 - 0.66 10.2 6.1 0.79 9.9 0.0 2.8 3 0 0 3 3 3 0 AAA domain MFS_1 PF07690.16 AAS50731.1 - 3e-39 135.0 37.0 1.8e-38 132.4 36.7 2.3 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS50731.1 - 1.1e-15 57.4 10.0 1.1e-15 57.4 10.0 2.8 2 1 1 3 3 3 1 Sugar (and other) transporter DUF3649 PF12365.8 AAS50731.1 - 2.4 8.0 5.8 14 5.5 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3649) Macro_2 PF14519.6 AAS50732.2 - 4e-65 219.9 0.0 1.3e-64 218.3 0.0 1.6 1 1 0 1 1 1 1 Macro-like domain DoxX_2 PF13564.6 AAS50732.2 - 0.78 9.9 5.4 1.8 8.7 4.9 1.8 2 0 0 2 2 2 0 DoxX-like family Aminotran_1_2 PF00155.21 AAS50733.2 - 1.8e-76 257.7 0.0 2e-76 257.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II SIS PF01380.22 AAS50735.2 - 4.9e-63 210.8 0.1 6.1e-32 110.2 0.2 2.2 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AAS50735.2 - 3.3e-17 62.9 0.0 6.9e-17 61.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AAS50735.2 - 1.2e-11 44.6 0.0 2.4e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 AAS50735.2 - 8.4e-07 28.2 0.1 1.4e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 AAS50735.2 - 0.097 11.4 0.5 0.33 9.6 0.2 1.8 1 1 1 2 2 2 0 Glutamine amidotransferases class-II Peptidase_M18 PF02127.15 AAS50736.2 - 2.7e-122 408.7 0.0 3.1e-122 408.5 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 AAS50736.2 - 0.00098 18.2 0.0 0.36 9.8 0.0 2.4 2 0 0 2 2 2 2 M42 glutamyl aminopeptidase Pkinase PF00069.25 AAS50737.1 - 1.4e-75 254.1 0.0 2.3e-75 253.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50737.1 - 7.1e-41 140.2 0.0 1.2e-40 139.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AAS50737.1 - 0.0038 16.6 0.0 0.0089 15.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AAS50737.1 - 0.0042 16.7 0.1 0.01 15.5 0.1 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 AAS50737.1 - 0.028 14.3 0.0 0.051 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family ADH_N PF08240.12 AAS50738.1 - 1.8e-28 98.6 0.5 3.4e-28 97.7 0.5 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS50738.1 - 1.8e-24 86.2 0.3 3e-24 85.5 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AAS50738.1 - 9.8e-08 33.1 0.0 1.7e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AAS50738.1 - 0.00046 19.7 0.3 0.0007 19.1 0.3 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus Utp11 PF03998.13 AAS50739.1 - 6.8e-70 235.8 30.0 7.8e-70 235.6 30.0 1.0 1 0 0 1 1 1 1 Utp11 protein SLATT_5 PF18160.1 AAS50739.1 - 0.03 13.7 0.4 0.03 13.7 0.4 1.8 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1574 PF07611.11 AAS50739.1 - 0.25 10.7 10.9 0.086 12.2 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1574) Ku PF02735.16 AAS50741.3 - 4.2e-34 118.0 0.1 6.5e-34 117.4 0.1 1.2 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 AAS50741.3 - 2.4e-09 37.3 0.3 3.5e-09 36.7 0.3 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain PGM_PMM_I PF02878.16 AAS50742.1 - 1.5e-33 115.4 0.2 2.3e-33 114.8 0.2 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 AAS50742.1 - 1.3e-24 86.5 0.0 2.5e-24 85.7 0.0 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 AAS50742.1 - 4e-12 46.7 0.0 9.4e-12 45.5 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 AAS50742.1 - 1.4e-05 25.1 0.0 4.8e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain Fer4_12 PF13353.6 AAS50742.1 - 0.0013 19.0 0.1 0.0068 16.7 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S single cluster domain Pkinase PF00069.25 AAS50743.2 - 1.3e-69 234.5 0.0 1.9e-69 234.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50743.2 - 3.9e-32 111.6 0.0 5.5e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 AAS50743.2 - 3.5e-11 43.6 0.4 1.1e-10 42.0 0.4 1.9 1 0 0 1 1 1 1 Protein kinase C terminal domain Haspin_kinase PF12330.8 AAS50743.2 - 1e-05 24.7 0.1 2e-05 23.7 0.1 1.3 1 1 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 AAS50743.2 - 0.0069 16.0 0.1 1.6 8.3 0.1 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AAS50743.2 - 0.012 14.9 0.0 0.05 12.9 0.0 1.9 2 0 0 2 2 2 0 Kinase-like Kdo PF06293.14 AAS50743.2 - 0.028 13.8 0.1 0.057 12.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4169 PF13770.6 AAS50743.2 - 0.043 14.1 1.4 0.082 13.2 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4169) NYAP_C PF15452.6 AAS50743.2 - 0.24 11.2 4.7 0.38 10.5 4.7 1.3 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter RRN3 PF05327.11 AAS50744.1 - 1e-182 608.7 5.4 1.2e-182 608.4 5.4 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 AAS50744.1 - 0.0013 17.1 1.1 0.0019 16.6 1.1 1.2 1 0 0 1 1 1 1 Nop14-like family GCIP PF13324.6 AAS50744.1 - 0.0018 17.9 3.1 0.004 16.8 3.1 1.5 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF1539 PF07560.11 AAS50744.1 - 1.4 9.1 4.0 6.3 6.9 0.1 3.1 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1539) SPRY PF00622.28 AAS50745.2 - 8.9e-11 42.0 0.0 1.9e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 SPRY domain SRP9-21 PF05486.12 AAS50746.2 - 1.3e-16 60.7 0.4 1.5e-15 57.4 0.0 2.4 2 1 0 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) Ribosomal_60s PF00428.19 AAS50746.2 - 0.97 10.1 7.9 1.8 9.2 7.0 2.0 1 1 2 3 3 3 0 60s Acidic ribosomal protein WD40 PF00400.32 AAS50747.1 - 1.7e-17 63.4 12.9 0.0006 20.6 0.2 6.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50747.1 - 1e-06 29.0 0.3 0.33 11.3 0.0 5.5 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS50747.1 - 0.0022 16.7 0.5 1.8 7.1 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 AAS50747.1 - 0.15 10.5 0.0 0.69 8.4 0.0 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain Mito_carr PF00153.27 AAS50748.2 - 6.4e-47 157.4 3.1 4.6e-16 58.5 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Prenyltransf PF01255.19 AAS50749.2 - 1.7e-63 214.1 0.2 3.3e-63 213.2 0.2 1.4 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Sipho_Gp157 PF05565.11 AAS50749.2 - 0.07 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Siphovirus Gp157 Vma12 PF11712.8 AAS50750.2 - 3.4e-25 88.7 0.0 5.5e-25 88.1 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase TcdA_TcdB_pore PF12920.7 AAS50750.2 - 0.51 8.5 1.9 0.67 8.1 1.9 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain Mobilization_B PF17511.2 AAS50750.2 - 0.91 9.9 6.7 2.4 8.6 4.5 2.0 2 0 0 2 2 2 0 Mobilization protein B zf-MYND PF01753.18 AAS50751.1 - 1.3e-05 25.2 24.3 4e-05 23.6 24.3 1.8 1 1 0 1 1 1 1 MYND finger FDX-ACB PF03147.14 AAS50751.1 - 0.05 14.0 0.6 5.2 7.6 0.0 2.6 2 0 0 2 2 2 0 Ferredoxin-fold anticodon binding domain Abhydrolase_1 PF00561.20 AAS50752.2 - 1.2e-18 67.7 0.4 6.5e-18 65.3 0.4 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AAS50752.2 - 1e-13 52.4 0.2 2.1e-13 51.4 0.2 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS50752.2 - 1.3e-10 41.0 0.0 1.3e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ser_hydrolase PF06821.13 AAS50752.2 - 7.4e-05 22.7 0.1 0.00012 22.0 0.1 1.2 1 0 0 1 1 1 1 Serine hydrolase Esterase PF00756.20 AAS50752.2 - 0.021 14.5 0.1 0.036 13.7 0.1 1.3 1 0 0 1 1 1 0 Putative esterase Abhydrolase_2 PF02230.16 AAS50752.2 - 0.13 12.0 0.5 0.47 10.2 0.4 1.9 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase AMP-binding PF00501.28 AAS50753.1 - 3.2e-88 296.2 0.0 4.6e-88 295.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AAS50753.1 - 0.0037 18.2 0.0 0.012 16.6 0.0 2.0 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Cauli_VI PF01693.16 AAS50754.2 - 2.1e-29 101.5 1.5 6.9e-17 61.5 0.1 2.4 2 0 0 2 2 2 2 Caulimovirus viroplasmin RNase_H PF00075.24 AAS50754.2 - 3.4e-23 82.4 0.0 5.6e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 RNase H Membr_traf_MHD PF10540.9 AAS50755.2 - 4.2e-49 166.5 0.9 1.1e-48 165.1 0.0 2.2 2 0 0 2 2 2 1 Munc13 (mammalian uncoordinated) homology domain C2 PF00168.30 AAS50755.2 - 1.9e-09 37.7 0.0 4.7e-09 36.5 0.0 1.7 1 0 0 1 1 1 1 C2 domain DUF810 PF05664.11 AAS50755.2 - 5.2e-06 25.3 3.8 6.6e-06 25.0 2.0 2.0 2 1 0 2 2 2 1 Plant family of unknown function (DUF810) DUF2890 PF11081.8 AAS50755.2 - 0.097 12.8 0.6 1.4 9.0 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2890) UPF0061 PF02696.14 AAS50755.2 - 0.22 10.3 2.2 3.1 6.4 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized ACR, YdiU/UPF0061 family SWIB PF02201.18 AAS50756.2 - 4.2e-30 103.5 0.1 9e-30 102.4 0.1 1.6 2 0 0 2 2 2 1 SWIB/MDM2 domain DEK_C PF08766.11 AAS50756.2 - 3.3e-11 42.9 0.7 1.6e-10 40.7 0.7 2.2 3 0 0 3 3 3 1 DEK C terminal domain RRS1 PF04939.12 AAS50757.2 - 1.1e-60 204.2 2.8 1.3e-60 204.0 2.8 1.0 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) RhoGEF PF00621.20 AAS50758.2 - 8.5e-14 52.2 3.3 8.5e-14 52.2 3.3 2.6 2 2 2 4 4 4 1 RhoGEF domain VPS11_C PF12451.8 AAS50759.2 - 1.2e-09 38.2 1.6 2.1e-09 37.4 0.0 2.2 2 0 0 2 2 2 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 AAS50759.2 - 2.1e-06 27.7 2.5 2.1e-06 27.7 2.5 2.0 2 0 0 2 2 2 1 Zinc-finger zf-RING_UBOX PF13445.6 AAS50759.2 - 0.00021 21.3 5.4 0.00063 19.7 5.4 1.9 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AAS50759.2 - 0.0003 20.7 4.7 0.00069 19.5 4.7 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AAS50759.2 - 0.0067 16.2 6.1 0.02 14.8 6.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 AAS50759.2 - 0.0094 15.8 3.1 0.035 14.0 3.1 2.1 1 0 0 1 1 1 1 PHD-finger zf-RING_11 PF17123.5 AAS50759.2 - 0.029 14.1 0.9 0.1 12.4 0.9 2.0 1 0 0 1 1 1 0 RING-like zinc finger TPR_11 PF13414.6 AAS50759.2 - 0.036 13.7 0.3 0.4 10.4 0.0 2.6 3 0 0 3 3 3 0 TPR repeat zf-RING_2 PF13639.6 AAS50759.2 - 0.037 14.4 5.8 0.094 13.1 5.8 1.8 1 0 0 1 1 1 0 Ring finger domain TPR_8 PF13181.6 AAS50759.2 - 0.15 12.3 0.2 1 9.7 0.2 2.6 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-C3HC4 PF00097.25 AAS50759.2 - 0.16 11.9 5.2 0.49 10.3 5.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AAS50759.2 - 0.25 11.5 7.6 0.25 11.6 5.6 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Zn_ribbon_17 PF17120.5 AAS50759.2 - 0.26 11.0 2.4 0.56 9.9 2.4 1.6 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 AAS50759.2 - 0.67 10.3 3.7 2.1 8.7 3.7 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain Pkinase PF00069.25 AAS50760.2 - 5.4e-66 222.7 0.1 2.2e-64 217.4 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50760.2 - 7.3e-47 159.8 0.0 3.4e-46 157.6 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Ras_bdg_2 PF14847.6 AAS50760.2 - 1.8e-35 121.3 0.1 4.1e-35 120.1 0.1 1.6 1 0 0 1 1 1 1 Ras-binding domain of Byr2 SAM_2 PF07647.17 AAS50760.2 - 5.9e-10 39.1 1.3 1.1e-09 38.3 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AAS50760.2 - 8.9e-09 35.7 0.1 3.3e-08 33.8 0.1 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Kinase-like PF14531.6 AAS50760.2 - 0.0016 17.8 0.0 0.01 15.1 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AAS50760.2 - 0.004 16.0 0.0 0.014 14.2 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Metallophos PF00149.28 AAS50762.2 - 3.8e-17 63.5 0.2 6.7e-17 62.7 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AAS50762.2 - 0.0027 17.9 0.0 0.02 15.1 0.0 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain VPS38 PF17649.1 AAS50763.2 - 8.9e-135 449.8 0.0 1e-134 449.6 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 38 APG6 PF04111.12 AAS50763.2 - 0.068 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Apg6 BARA domain Atg14 PF10186.9 AAS50763.2 - 0.099 11.7 4.4 0.31 10.1 4.2 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Folliculin PF11704.8 AAS50764.1 - 2.4e-43 148.2 0.1 3.2e-43 147.8 0.1 1.2 1 0 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport DUF2321 PF10083.9 AAS50764.1 - 0.14 11.8 0.3 0.25 11.0 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Lyase_1 PF00206.20 AAS50765.2 - 2.8e-23 82.8 0.0 5.4e-23 81.9 0.0 1.4 1 0 0 1 1 1 1 Lyase ADSL_C PF10397.9 AAS50765.2 - 1.5e-19 70.3 0.1 9.5e-19 67.7 0.0 2.4 2 0 0 2 2 2 1 Adenylosuccinate lyase C-terminus DUF1331 PF07048.11 AAS50765.2 - 0.19 11.5 0.1 0.36 10.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1331) Bromodomain PF00439.25 AAS50766.2 - 2.7e-30 104.3 2.8 4.7e-14 52.2 0.1 2.5 2 0 0 2 2 2 2 Bromodomain BAH PF01426.18 AAS50766.2 - 3.9e-25 88.1 0.2 1.3e-24 86.4 0.2 2.0 1 0 0 1 1 1 1 BAH domain SIR2 PF02146.17 AAS50767.1 - 1.5e-31 109.7 0.0 3.9e-31 108.3 0.0 1.6 1 1 0 1 1 1 1 Sir2 family AA_permease_2 PF13520.6 AAS50768.1 - 7.3e-87 291.9 35.1 9.2e-87 291.6 35.1 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AAS50768.1 - 1.9e-15 56.5 31.6 2.9e-15 55.9 31.6 1.2 1 0 0 1 1 1 1 Amino acid permease PAP_central PF04928.17 AAS50769.1 - 1.5e-110 368.0 0.0 3.2e-110 367.0 0.0 1.5 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 AAS50769.1 - 6.8e-55 185.3 4.3 1.1e-54 184.6 4.3 1.4 1 0 0 1 1 1 1 Poly(A) polymerase predicted RNA binding domain NTP_transf_2 PF01909.23 AAS50769.1 - 1.1e-13 51.3 0.1 7.1e-13 48.7 0.0 2.4 1 1 1 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 AAS50769.1 - 0.0078 16.3 0.0 0.033 14.3 0.0 2.0 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase Nrap_D2 PF17403.2 AAS50769.1 - 0.01 15.6 0.1 0.053 13.3 0.0 2.2 2 1 0 2 2 2 0 Nrap protein PAP/OAS-like domain Dynamin_M PF01031.20 AAS50770.1 - 3.6e-97 325.0 0.1 1.1e-96 323.4 0.0 1.9 3 0 0 3 3 3 1 Dynamin central region Dynamin_N PF00350.23 AAS50770.1 - 2.9e-58 196.7 0.0 5.9e-58 195.6 0.0 1.6 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 AAS50770.1 - 2e-27 95.2 4.9 2e-27 95.2 4.9 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 AAS50770.1 - 0.00047 20.2 0.1 0.0016 18.5 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase HTH_9 PF08221.11 AAS50770.1 - 0.15 12.2 0.9 0.41 10.8 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain APS_kinase PF01583.20 AAS50771.1 - 1.7e-73 245.8 0.0 2e-73 245.5 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 AAS50771.1 - 2.3e-05 24.6 0.0 4.7e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS50771.1 - 0.001 19.6 0.0 0.0024 18.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 AAS50771.1 - 0.0029 17.1 0.0 0.0033 16.9 0.0 1.3 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_29 PF13555.6 AAS50771.1 - 0.014 15.1 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 AAS50771.1 - 0.015 15.8 0.0 0.02 15.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter CPT PF07931.12 AAS50771.1 - 0.015 15.1 0.3 0.56 10.0 0.3 2.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_16 PF13191.6 AAS50771.1 - 0.02 15.3 0.0 0.027 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Snf7 PF03357.21 AAS50772.1 - 7.8e-29 100.5 23.7 1.1e-28 100.0 22.3 1.7 2 0 0 2 2 2 1 Snf7 Ist1 PF03398.14 AAS50772.1 - 2.4e-06 27.6 8.3 3.5e-06 27.0 8.3 1.2 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Remorin_C PF03763.13 AAS50772.1 - 0.86 9.5 11.4 2 8.4 10.6 1.9 1 1 0 1 1 1 0 Remorin, C-terminal region DUF87 PF01935.17 AAS50772.1 - 1.8 8.6 7.7 1.8 8.6 0.1 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain Uds1 PF15456.6 AAS50772.1 - 2.7 8.2 15.6 0.082 13.1 2.7 2.8 1 1 0 2 2 2 0 Up-regulated During Septation Syntaxin-6_N PF09177.11 AAS50772.1 - 5.4 7.6 12.2 1.5 9.5 4.9 3.0 1 1 1 3 3 3 0 Syntaxin 6, N-terminal HAT_KAT11 PF08214.11 AAS50772.1 - 7.7 5.7 8.7 1.4 8.1 0.4 2.1 1 1 1 2 2 2 0 Histone acetylation protein Ribosomal_S6 PF01250.17 AAS50773.1 - 1.2e-23 83.2 0.0 1.5e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S6 KI67R PF08065.12 AAS50773.1 - 0.16 12.5 0.1 0.34 11.5 0.0 1.5 2 0 0 2 2 2 0 KI67R (NUC007) repeat PAP2_3 PF14378.6 AAS50774.2 - 6.2e-25 88.0 12.2 6.2e-25 88.0 12.2 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2 PF01569.21 AAS50774.2 - 6.1e-11 42.2 7.5 6.1e-11 42.2 7.5 2.0 2 0 0 2 2 2 1 PAP2 superfamily LapD_MoxY_N PF16448.5 AAS50774.2 - 0.2 11.5 0.1 0.79 9.6 0.0 1.9 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain Ribosomal_L14e PF01929.17 AAS50775.1 - 5.9e-33 113.2 0.4 9.1e-33 112.6 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L14 KOW PF00467.29 AAS50775.1 - 2.6e-05 24.0 0.4 5.6e-05 22.9 0.4 1.6 1 0 0 1 1 1 1 KOW motif CK2S PF15011.6 AAS50776.1 - 0.057 13.3 0.0 0.07 13.0 0.0 1.2 1 0 0 1 1 1 0 Casein Kinase 2 substrate F-actin_cap_A PF01267.17 AAS50777.1 - 9.1e-70 235.1 0.0 1.1e-69 234.9 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein alpha subunit VHS PF00790.19 AAS50778.1 - 1e-31 109.6 0.1 2.2e-31 108.6 0.1 1.6 1 0 0 1 1 1 1 VHS domain SH3_1 PF00018.28 AAS50778.1 - 2.8e-16 58.8 0.1 4.6e-16 58.2 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS50778.1 - 3.1e-15 55.6 0.2 5.2e-15 54.9 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 AAS50778.1 - 3.8e-14 52.3 0.1 7.4e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain GAT PF03127.14 AAS50778.1 - 1.3e-06 28.6 0.7 1.6e-05 25.1 0.4 2.7 2 1 0 2 2 2 1 GAT domain Hrs_helical PF12210.8 AAS50778.1 - 0.2 12.2 0.1 0.2 12.2 0.1 1.9 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DivIVA PF05103.13 AAS50778.1 - 0.3 11.2 4.1 2.7 8.1 0.1 2.8 3 0 0 3 3 3 0 DivIVA protein UIM PF02809.20 AAS50778.1 - 5.8 7.1 12.9 0.16 12.0 5.7 2.3 2 0 0 2 2 2 0 Ubiquitin interaction motif TRAM_LAG1_CLN8 PF03798.16 AAS50779.1 - 1.6e-38 132.4 22.9 1.6e-38 132.4 22.9 2.4 2 1 0 2 2 2 1 TLC domain TRAM1 PF08390.11 AAS50779.1 - 5.6e-23 80.4 1.3 1.4e-22 79.1 1.3 1.7 1 0 0 1 1 1 1 TRAM1-like protein DUF4834 PF16118.5 AAS50779.1 - 0.11 13.4 0.1 4.8 8.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Herpes_LMP1 PF05297.11 AAS50779.1 - 0.21 10.8 5.0 0.3 10.3 5.0 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PSII PF00421.19 AAS50779.1 - 0.91 8.1 6.7 0.4 9.3 3.9 1.7 1 1 0 1 1 1 0 Photosystem II protein Ribosomal_S2 PF00318.20 AAS50780.2 - 9.7e-64 214.5 0.0 6.8e-63 211.8 0.0 2.0 1 1 0 1 1 1 1 Ribosomal protein S2 Ribosomal_L10 PF00466.20 AAS50782.1 - 8e-18 64.4 0.0 1.3e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 AAS50782.1 - 1.1e-17 63.8 0.0 1.8e-17 63.1 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P HECT PF00632.25 AAS50783.2 - 5.9e-71 239.4 0.0 1.2e-70 238.5 0.0 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Pkinase PF00069.25 AAS50784.2 - 3.8e-73 246.1 0.0 5.3e-73 245.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50784.2 - 1.7e-46 158.6 0.0 2.9e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AAS50784.2 - 5.7e-23 81.0 0.0 1.4e-22 79.8 0.0 1.7 1 0 0 1 1 1 1 P21-Rho-binding domain Kinase-like PF14531.6 AAS50784.2 - 1.3e-05 24.7 0.0 2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AAS50784.2 - 4.5e-05 22.4 0.0 0.00014 20.8 0.0 1.8 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 AAS50784.2 - 0.17 11.8 0.0 0.17 11.8 0.0 2.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family Kdo PF06293.14 AAS50784.2 - 0.19 11.1 0.0 0.49 9.7 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family CENP-C_C PF11699.8 AAS50785.1 - 2.2e-29 101.5 2.0 3.8e-29 100.7 2.0 1.4 1 0 0 1 1 1 1 Mif2/CENP-C like Mif2_N PF15624.6 AAS50785.1 - 4.1e-08 34.0 0.7 4.1e-08 34.0 0.7 2.9 3 1 0 3 3 3 1 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Cupin_2 PF07883.11 AAS50785.1 - 5.1e-06 26.1 0.0 1.2e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 Cupin domain MannoseP_isomer PF01050.18 AAS50785.1 - 0.026 14.4 0.0 0.056 13.3 0.0 1.5 1 0 0 1 1 1 0 Mannose-6-phosphate isomerase MID_MedPIWI PF18296.1 AAS50785.1 - 0.17 11.7 1.9 0.36 10.6 1.9 1.9 1 1 0 1 1 1 0 MID domain of medPIWI CUE PF02845.16 AAS50786.2 - 3e-17 62.0 0.9 7.5e-10 38.3 0.1 3.2 3 0 0 3 3 3 2 CUE domain DMA PF03474.14 AAS50786.2 - 1.7e-10 40.3 0.0 0.0007 19.1 0.0 3.3 3 0 0 3 3 3 3 DMRTA motif Smr PF01713.21 AAS50786.2 - 7.5e-06 26.2 0.0 2e-05 24.9 0.0 1.7 1 0 0 1 1 1 1 Smr domain DUF1296 PF06972.11 AAS50786.2 - 0.082 13.1 0.0 5.3 7.3 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) 2OG-FeII_Oxy_3 PF13640.6 AAS50787.2 - 1e-09 39.1 0.4 2e-09 38.2 0.4 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily bZIP_1 PF00170.21 AAS50788.1 - 1.3e-05 25.2 19.5 2.1e-05 24.5 18.8 1.6 1 1 1 2 2 2 2 bZIP transcription factor CASP_C PF08172.12 AAS50788.1 - 0.0028 17.1 0.6 0.0034 16.8 0.6 1.2 1 0 0 1 1 1 1 CASP C terminal NRBF2 PF08961.10 AAS50788.1 - 0.0076 15.9 0.3 0.0098 15.5 0.3 1.2 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator V_ATPase_I PF01496.19 AAS50788.1 - 0.0077 14.2 1.8 0.0091 14.0 1.8 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family bZIP_2 PF07716.15 AAS50788.1 - 0.01 15.9 18.4 0.01 15.9 18.4 1.5 1 1 0 1 1 1 0 Basic region leucine zipper YabA PF06156.13 AAS50788.1 - 0.018 15.6 0.8 0.03 14.9 0.8 1.3 1 0 0 1 1 1 0 Initiation control protein YabA RIC3 PF15361.6 AAS50788.1 - 0.085 13.3 0.2 0.14 12.5 0.2 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF4792 PF16040.5 AAS50788.1 - 0.15 12.0 0.0 0.41 10.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4792) DUF2205 PF10224.9 AAS50788.1 - 0.38 10.8 8.7 0.68 10.0 8.7 1.4 1 0 0 1 1 1 0 Short coiled-coil protein bZIP_Maf PF03131.17 AAS50788.1 - 0.42 11.2 12.0 0.64 10.6 12.0 1.2 1 0 0 1 1 1 0 bZIP Maf transcription factor Glutaredoxin2_C PF04399.13 AAS50788.1 - 0.82 9.5 4.2 0.56 10.0 2.0 1.8 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain DUF4407 PF14362.6 AAS50788.1 - 1 8.7 4.4 1.4 8.2 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF349 PF03993.12 AAS50788.1 - 1 9.7 10.8 1.6 9.1 10.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) IATP PF04568.12 AAS50788.1 - 2.8 8.4 6.8 6.3 7.3 6.8 1.6 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP AAA PF00004.29 AAS50789.1 - 1.3e-12 48.3 0.0 6.3e-11 42.8 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS50789.1 - 2.1e-06 28.2 0.0 0.00012 22.6 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain Rad17 PF03215.15 AAS50789.1 - 5.1e-06 26.5 0.0 4.9e-05 23.3 0.0 2.1 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 AAS50789.1 - 8.2e-05 22.9 0.0 0.0016 18.8 0.0 2.7 2 0 0 2 2 2 1 AAA C-terminal domain AAA_22 PF13401.6 AAS50789.1 - 0.00012 22.4 0.0 0.005 17.1 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 AAS50789.1 - 0.00051 20.2 0.3 0.002 18.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 AAS50789.1 - 0.00062 19.5 0.0 0.0018 18.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 AAS50789.1 - 0.00063 19.8 0.4 0.0024 17.9 0.0 2.2 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 AAS50789.1 - 0.012 16.0 0.0 0.029 14.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 AAS50789.1 - 0.031 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AAS50789.1 - 0.041 13.8 0.0 0.096 12.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 AAS50789.1 - 0.044 14.3 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 AAS50789.1 - 0.044 13.8 0.0 0.084 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 AAS50789.1 - 0.096 12.4 0.1 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 Thymidylate kinase IPT PF01745.16 AAS50789.1 - 0.12 11.7 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Isopentenyl transferase CRAL_TRIO PF00650.20 AAS50790.2 - 9.8e-35 119.6 0.0 1.3e-34 119.2 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AAS50790.2 - 3.1e-09 36.9 0.6 7.5e-09 35.6 0.6 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AAS50790.2 - 0.016 15.4 0.0 0.03 14.5 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain DUF1769 PF08588.10 AAS50790.2 - 0.15 12.3 0.1 0.34 11.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1769) RasGAP PF00616.19 AAS50791.2 - 2.3e-44 151.6 1.9 3.3e-43 147.8 1.9 2.3 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase C2 PF00168.30 AAS50791.2 - 4.5e-06 26.9 0.1 1e-05 25.7 0.1 1.6 1 0 0 1 1 1 1 C2 domain UPF1_Zn_bind PF09416.10 AAS50792.4 - 2.3e-63 212.7 14.9 3.6e-63 212.1 11.9 2.3 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_12 PF13087.6 AAS50792.4 - 1.1e-57 194.9 0.0 1.9e-57 194.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AAS50792.4 - 1.5e-49 169.1 4.5 2.1e-26 93.3 0.7 2.3 1 1 1 2 2 2 2 AAA domain DUF5599 PF18141.1 AAS50792.4 - 2.2e-29 101.6 0.0 5e-29 100.4 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 AAS50792.4 - 3.8e-17 62.6 0.4 1.8e-15 57.2 0.4 2.2 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AAS50792.4 - 6.3e-13 49.3 0.1 1.4e-12 48.2 0.1 1.6 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 AAS50792.4 - 1.2e-05 24.7 0.1 0.00057 19.2 0.0 3.0 3 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) ResIII PF04851.15 AAS50792.4 - 2.7e-05 24.2 0.0 6.8e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Viral_helicase1 PF01443.18 AAS50792.4 - 4.8e-05 23.2 0.0 0.3 10.8 0.0 3.0 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 AAS50792.4 - 0.00037 20.1 0.0 0.05 13.1 0.0 2.5 1 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Helicase_RecD PF05127.14 AAS50792.4 - 0.0006 19.7 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Helicase PIF1 PF05970.14 AAS50792.4 - 0.00073 18.8 0.1 0.61 9.2 0.1 2.2 1 1 0 2 2 2 2 PIF1-like helicase Flavi_DEAD PF07652.14 AAS50792.4 - 0.029 14.4 0.1 0.067 13.2 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain PhoH PF02562.16 AAS50792.4 - 0.03 13.8 0.0 0.069 12.6 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein DEAD PF00270.29 AAS50792.4 - 0.039 13.7 0.1 0.076 12.8 0.1 1.5 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_24 PF13479.6 AAS50792.4 - 0.054 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AAS50792.4 - 0.062 13.6 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 AAS50792.4 - 0.07 12.0 0.0 0.12 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain ATPase PF06745.13 AAS50792.4 - 0.076 12.3 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 KaiC SRP54 PF00448.22 AAS50792.4 - 0.084 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain T2SSE PF00437.20 AAS50792.4 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein MBR1 PF17058.5 AAS50793.1 - 3.1e-16 60.3 16.4 1.1e-13 52.0 7.0 3.2 1 1 1 2 2 2 2 Mitochondrial biogenesis regulation protein 1 DUF572 PF04502.13 AAS50794.1 - 5e-46 157.8 3.5 5.9e-46 157.6 3.5 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF572) TF_Zn_Ribbon PF08271.12 AAS50794.1 - 0.052 13.1 0.4 0.052 13.1 0.4 1.9 2 0 0 2 2 2 0 TFIIB zinc-binding zf_UBZ PF18439.1 AAS50794.1 - 0.33 10.6 2.2 3.2 7.4 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger PIN_9 PF18477.1 AAS50794.1 - 0.46 10.8 3.4 0.64 10.4 1.8 2.0 1 1 0 1 1 1 0 PIN like domain RNA_pol_Rpb2_6 PF00562.28 AAS50799.2 - 2.2e-113 379.3 0.0 4.2e-113 378.3 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AAS50799.2 - 3.2e-44 150.9 0.0 4.6e-44 150.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AAS50799.2 - 4.1e-31 108.1 0.0 8.7e-31 107.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_3 PF04565.16 AAS50799.2 - 2.8e-28 97.9 0.0 1.7e-27 95.4 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpa2_4 PF06883.12 AAS50799.2 - 3e-24 84.8 0.0 7.4e-24 83.5 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_7 PF04560.20 AAS50799.2 - 4.4e-16 59.1 0.0 1.1e-14 54.6 0.0 2.6 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 7 DUF2666 PF10869.8 AAS50799.2 - 0.099 12.9 0.0 3.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2666) DUF3833 PF12915.7 AAS50800.2 - 0.082 12.5 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) Thg1 PF04446.12 AAS50801.1 - 3.8e-50 169.1 0.4 5.9e-50 168.5 0.4 1.3 1 0 0 1 1 1 1 tRNAHis guanylyltransferase Thg1C PF14413.6 AAS50801.1 - 2.8e-37 127.6 0.6 7.4e-37 126.2 0.4 1.8 2 0 0 2 2 2 1 Thg1 C terminal domain UPF0121 PF03661.13 AAS50802.2 - 0.0052 16.2 14.0 0.0079 15.6 6.4 2.5 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0121) DUF3481 PF11980.8 AAS50802.2 - 0.2 11.4 0.3 1.2 8.8 0.3 2.1 2 0 0 2 2 2 0 C-terminal domain of neuropilin glycoprotein Ribosomal_S25 PF03297.15 AAS50803.1 - 8e-39 131.9 6.5 9e-39 131.8 6.5 1.0 1 0 0 1 1 1 1 S25 ribosomal protein FtsK_gamma PF09397.10 AAS50803.1 - 0.00073 19.3 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Ftsk gamma domain HTH_CodY PF08222.11 AAS50803.1 - 0.023 14.3 0.1 0.036 13.6 0.1 1.3 1 0 0 1 1 1 0 CodY helix-turn-helix domain EAP30 PF04157.16 AAS50803.1 - 0.062 12.6 0.1 0.081 12.2 0.1 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Ran_BP1 PF00638.18 AAS50804.2 - 9.2e-31 106.6 0.4 2.1e-30 105.5 0.1 1.8 2 0 0 2 2 2 1 RanBP1 domain NUP50 PF08911.11 AAS50804.2 - 7.8e-12 45.7 2.4 7.8e-12 45.7 2.4 3.9 5 1 0 5 5 5 1 NUP50 (Nucleoporin 50 kDa) Serglycin PF04360.12 AAS50804.2 - 0.1 12.6 0.2 0.35 10.8 0.2 1.9 1 0 0 1 1 1 0 Serglycin MA3 PF02847.17 AAS50805.3 - 7.1e-25 87.2 0.3 1.9e-24 85.8 0.3 1.8 1 0 0 1 1 1 1 MA3 domain MIF4G PF02854.19 AAS50805.3 - 1.2e-22 80.6 1.3 2.7e-22 79.5 1.3 1.7 1 0 0 1 1 1 1 MIF4G domain Blt1 PF12754.7 AAS50805.3 - 0.023 15.0 0.5 0.061 13.6 0.5 1.7 1 0 0 1 1 1 0 Blt1 N-terminal domain AAA PF00004.29 AAS50806.2 - 7.6e-38 129.9 0.0 1.2e-37 129.3 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS50806.2 - 2.7e-10 39.9 0.3 5.8e-10 38.8 0.3 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_14 PF13173.6 AAS50806.2 - 1.6e-06 28.1 0.0 4.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AAS50806.2 - 4e-06 26.7 0.0 9.1e-06 25.5 0.0 1.6 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AAS50806.2 - 4.6e-06 27.1 0.7 0.00075 19.9 0.0 3.0 2 1 0 3 3 3 1 AAA ATPase domain AAA_22 PF13401.6 AAS50806.2 - 9.2e-06 26.0 0.1 0.012 15.9 0.0 3.3 1 1 2 3 3 3 1 AAA domain AAA_5 PF07728.14 AAS50806.2 - 1.1e-05 25.4 0.1 9.3e-05 22.4 0.1 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 AAS50806.2 - 1.8e-05 24.9 0.0 3.4e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TniB PF05621.11 AAS50806.2 - 3.7e-05 23.2 0.0 0.47 9.8 0.0 2.9 1 1 1 3 3 3 2 Bacterial TniB protein Sigma54_activ_2 PF14532.6 AAS50806.2 - 0.00012 22.2 0.0 0.00023 21.3 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_18 PF13238.6 AAS50806.2 - 0.00016 22.2 0.0 0.0004 20.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AAS50806.2 - 0.00043 20.1 0.0 0.00072 19.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 AAS50806.2 - 0.00083 18.6 0.0 0.0013 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 AAS50806.2 - 0.00089 18.7 0.2 0.0026 17.2 0.1 1.7 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AAS50806.2 - 0.00099 19.5 0.0 0.0027 18.1 0.0 2.0 1 1 0 1 1 1 1 RNA helicase AAA_25 PF13481.6 AAS50806.2 - 0.0016 18.0 0.3 0.047 13.3 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AAS50806.2 - 0.002 18.3 0.0 0.0053 16.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AAS50806.2 - 0.0022 17.5 0.0 0.0084 15.6 0.0 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region Rad17 PF03215.15 AAS50806.2 - 0.0058 16.6 0.0 0.016 15.1 0.0 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain Zeta_toxin PF06414.12 AAS50806.2 - 0.0061 15.9 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_24 PF13479.6 AAS50806.2 - 0.0075 16.0 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 AAS50806.2 - 0.0091 16.3 0.1 0.35 11.1 0.0 2.4 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 AAS50806.2 - 0.01 16.3 0.0 0.03 14.8 0.0 1.9 2 0 0 2 2 1 0 AAA domain TIP49 PF06068.13 AAS50806.2 - 0.012 14.8 0.1 0.036 13.3 0.0 1.7 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_28 PF13521.6 AAS50806.2 - 0.02 15.2 0.0 0.054 13.7 0.0 1.8 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 AAS50806.2 - 0.02 14.6 0.0 0.06 13.1 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 AAS50806.2 - 0.021 15.3 0.0 0.055 14.0 0.0 1.9 2 1 0 2 2 1 0 ABC transporter NACHT PF05729.12 AAS50806.2 - 0.035 14.0 0.0 0.098 12.6 0.0 1.8 1 0 0 1 1 1 0 NACHT domain CoA_transf_3 PF02515.17 AAS50806.2 - 0.046 12.8 0.0 0.081 12.0 0.0 1.3 1 0 0 1 1 1 0 CoA-transferase family III AAA_3 PF07726.11 AAS50806.2 - 0.048 13.5 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FCH PF00611.23 AAS50806.2 - 0.061 13.6 0.0 0.6 10.4 0.0 2.4 2 0 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Parvo_NS1 PF01057.17 AAS50806.2 - 0.061 12.4 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 AAS50806.2 - 0.064 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 AAS50806.2 - 0.065 13.3 0.1 0.98 9.5 0.0 2.4 2 0 0 2 2 2 0 Shikimate kinase AAA_6 PF12774.7 AAS50806.2 - 0.071 12.1 0.0 0.11 11.4 0.0 1.3 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Viral_helicase1 PF01443.18 AAS50806.2 - 0.099 12.4 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.14 AAS50806.2 - 0.11 11.7 0.4 14 4.8 0.0 2.8 2 1 0 3 3 3 0 KAP family P-loop domain ATPase_2 PF01637.18 AAS50806.2 - 0.14 12.0 0.1 0.85 9.5 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Evr1_Alr PF04777.13 AAS50807.3 - 1.2e-30 106.0 3.6 1.2e-30 105.9 2.3 1.6 2 0 0 2 2 2 1 Erv1 / Alr family LolA_2 PF16584.5 AAS50807.3 - 0.012 15.5 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA WH2 PF02205.20 AAS50808.2 - 1.2e-15 56.7 0.2 1.1e-10 41.0 0.3 2.7 2 0 0 2 2 2 2 WH2 motif OTU PF02338.19 AAS50809.2 - 4.9e-22 78.8 2.0 5.2e-22 78.7 0.1 2.0 2 0 0 2 2 2 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 AAS50809.2 - 0.00019 21.0 0.0 0.0025 17.3 0.0 2.3 2 0 0 2 2 2 1 Peptidase C65 Otubain DUF603 PF04645.12 AAS50809.2 - 0.071 12.8 0.6 0.14 11.8 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF603 DUF1878 PF08963.10 AAS50809.2 - 0.17 12.4 1.6 0.44 11.1 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1878) Cep57_MT_bd PF06657.13 AAS50809.2 - 0.21 12.0 5.6 0.62 10.6 5.6 1.8 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 DUF4407 PF14362.6 AAS50809.2 - 5.9 6.1 17.1 8.6 5.6 17.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YchF-GTPase_C PF06071.13 AAS50810.2 - 6.2e-34 116.0 0.0 1.1e-33 115.2 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AAS50810.2 - 5.8e-15 55.4 0.0 1.5e-14 54.0 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.21 AAS50810.2 - 2.2e-05 24.4 0.1 0.00011 22.2 0.1 2.0 1 1 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AAS50810.2 - 0.00096 18.7 0.1 0.0022 17.5 0.0 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B Ribosomal_S10 PF00338.22 AAS50811.1 - 2.5e-24 85.3 0.2 3.2e-24 85.0 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e Retrotrans_gag PF03732.17 AAS50811.1 - 0.086 13.1 0.0 0.14 12.5 0.0 1.5 1 1 0 1 1 1 0 Retrotransposon gag protein Cnl2_NKP2 PF09447.10 AAS50811.1 - 0.33 11.1 2.0 0.46 10.7 0.6 1.8 2 0 0 2 2 2 0 Cnl2/NKP2 family protein DUF1688 PF07958.11 AAS50812.2 - 2.6e-148 494.2 0.0 2.9e-148 494.1 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) SSF PF00474.17 AAS50813.2 - 1.7e-20 73.3 26.7 2.6e-20 72.7 26.7 1.3 1 0 0 1 1 1 1 Sodium:solute symporter family DUF1240 PF06836.12 AAS50813.2 - 0.12 12.9 2.3 7.7 7.1 0.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) DUF2852 PF11014.8 AAS50813.2 - 5.2 7.3 5.7 6.7 6.9 1.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) Lung_7-TM_R PF06814.13 AAS50814.2 - 5.7e-66 222.7 24.2 6.8e-66 222.5 24.2 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor NifU PF01106.17 AAS50815.1 - 1.1e-25 89.5 0.1 2.5e-25 88.4 0.1 1.6 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 AAS50815.1 - 2.6e-23 81.9 0.0 1e-22 80.0 0.0 2.0 3 0 0 3 3 3 1 Scaffold protein Nfu/NifU N terminal Pterin_4a PF01329.19 AAS50816.1 - 2.6e-25 88.4 0.0 3.1e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Adap_comp_sub PF00928.21 AAS50817.1 - 3.8e-56 190.4 0.0 5.2e-56 189.9 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AAS50817.1 - 0.087 12.8 0.1 0.2 11.6 0.1 1.5 1 0 0 1 1 1 0 Clathrin adaptor complex small chain Opi1 PF08618.10 AAS50818.1 - 4.9e-34 118.3 2.2 1.1e-20 74.3 0.0 3.1 1 1 2 3 3 3 3 Transcription factor Opi1 bact-PGI_C PF10432.9 AAS50818.1 - 0.017 15.2 0.7 7.9 6.5 0.0 3.2 3 0 0 3 3 3 0 Bacterial phospho-glucose isomerase C-terminal SIS domain Ribosomal_S13 PF00416.22 AAS50818.1 - 0.32 11.4 6.2 0.14 12.6 1.7 2.1 2 0 0 2 2 2 0 Ribosomal protein S13/S18 FliJ PF02050.16 AAS50818.1 - 0.38 11.0 13.1 0.21 11.8 8.9 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Snf7 PF03357.21 AAS50819.2 - 1.5e-29 102.8 16.4 1.5e-29 102.8 16.4 1.8 2 0 0 2 2 2 1 Snf7 SurA_N_3 PF13624.6 AAS50819.2 - 0.0063 16.3 2.1 0.0063 16.3 2.1 2.5 1 1 2 4 4 4 1 SurA N-terminal domain PAS_7 PF12860.7 AAS50819.2 - 0.028 14.6 1.5 0.28 11.4 0.2 2.5 1 1 2 3 3 3 0 PAS fold Caleosin PF05042.13 AAS50819.2 - 0.052 13.5 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 Caleosin related protein CRR7 PF12095.8 AAS50819.2 - 0.082 13.4 3.7 0.1 13.1 0.2 2.8 2 1 2 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF4944 PF16302.5 AAS50819.2 - 0.2 11.7 2.9 0.14 12.2 0.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4944) BNIP2 PF12496.8 AAS50819.2 - 0.81 10.1 6.9 2 8.9 6.8 1.7 1 1 1 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CLU PF13236.6 AAS50820.2 - 3.1e-63 213.6 0.2 5.3e-63 212.8 0.2 1.4 1 0 0 1 1 1 1 Clustered mitochondria eIF3_p135 PF12807.7 AAS50820.2 - 2e-35 122.4 0.0 2e-35 122.4 0.0 2.9 4 0 0 4 4 4 1 Translation initiation factor eIF3 subunit 135 CLU_N PF15044.6 AAS50820.2 - 5.6e-19 68.3 4.0 1.3e-18 67.1 0.4 3.3 2 0 0 2 2 2 1 Mitochondrial function, CLU-N-term TPR_12 PF13424.6 AAS50820.2 - 5.2e-12 45.9 6.9 7.3e-06 26.2 0.5 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 AAS50820.2 - 1.3e-11 44.0 0.4 3.2e-05 23.6 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50820.2 - 0.0011 19.0 4.1 0.12 12.6 0.5 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 AAS50820.2 - 0.0026 17.7 1.2 1.2 9.4 0.0 3.5 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50820.2 - 0.0035 17.3 1.5 2.3 8.5 0.2 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF727 PF05303.12 AAS50820.2 - 0.006 16.6 0.0 0.02 15.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF727) DUF3856 PF12968.7 AAS50820.2 - 0.081 13.0 0.1 4.6 7.3 0.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) TPR_1 PF00515.28 AAS50820.2 - 0.23 11.4 4.5 5.9 6.9 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF3446 PF11928.8 AAS50820.2 - 0.58 10.5 3.4 3.9 7.8 0.3 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain MgtC PF02308.16 AAS50821.2 - 0.013 15.8 4.5 0.013 15.8 4.5 3.7 3 1 0 3 3 3 0 MgtC family BUD22 PF09073.10 AAS50822.2 - 1.9e-85 287.8 34.8 2.3e-85 287.5 34.8 1.1 1 0 0 1 1 1 1 BUD22 p450 PF00067.22 AAS50823.1 - 1.9e-46 158.8 0.0 2.4e-46 158.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Spc42p PF11544.8 AAS50824.1 - 2.2e-32 110.8 2.5 3.5e-31 107.0 0.1 2.5 2 0 0 2 2 2 1 Spindle pole body component Spc42p Dynamitin PF04912.14 AAS50824.1 - 0.0044 16.4 5.5 0.2 10.9 0.8 2.1 2 0 0 2 2 2 2 Dynamitin DivIVA PF05103.13 AAS50824.1 - 0.006 16.7 3.3 0.025 14.7 0.7 2.4 2 0 0 2 2 2 1 DivIVA protein PhoU PF01895.19 AAS50824.1 - 0.007 16.8 1.2 2.2 8.8 0.1 3.1 3 0 0 3 3 3 1 PhoU domain YabA PF06156.13 AAS50824.1 - 0.03 15.0 1.3 0.63 10.7 0.1 2.5 2 1 0 2 2 2 0 Initiation control protein YabA DNA_pol3_delta PF06144.13 AAS50824.1 - 0.056 13.2 4.7 0.17 11.6 0.1 2.4 3 0 0 3 3 3 0 DNA polymerase III, delta subunit Troponin PF00992.20 AAS50824.1 - 0.2 12.0 6.1 0.17 12.1 0.5 2.9 3 0 0 3 3 3 0 Troponin NPV_P10 PF05531.12 AAS50824.1 - 1.1 9.8 8.4 7.4 7.1 0.2 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 AAS50824.1 - 1.3 9.6 7.8 31 5.3 1.5 3.9 3 1 1 4 4 4 0 SlyX UPF0242 PF06785.11 AAS50824.1 - 1.9 8.6 10.5 9.2 6.3 2.3 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4391 PF14335.6 AAS50824.1 - 4.8 6.8 8.2 4.9 6.8 0.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4391) KilA-N PF04383.13 AAS50825.2 - 6.5e-05 22.8 0.0 0.00058 19.7 0.0 2.2 1 1 0 1 1 1 1 KilA-N domain DNA_primase_lrg PF04104.14 AAS50826.1 - 8.5e-76 254.9 0.0 1.1e-75 254.5 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit Amino_oxidase PF01593.24 AAS50827.2 - 3.7e-55 188.0 0.1 4.9e-55 187.6 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 AAS50827.2 - 3.8e-13 49.4 0.2 1e-12 48.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 AAS50827.2 - 8.6e-07 28.4 3.3 3.8e-05 23.0 5.0 2.1 1 1 1 2 2 2 1 FAD binding domain FAD_binding_3 PF01494.19 AAS50827.2 - 6.1e-05 22.4 0.8 0.0001 21.7 0.8 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 AAS50827.2 - 8.7e-05 22.3 0.8 0.00022 20.9 0.8 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 AAS50827.2 - 0.00041 19.7 2.3 0.0025 17.1 1.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AAS50827.2 - 0.0014 18.0 0.9 0.0025 17.1 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS50827.2 - 0.0071 15.6 0.4 0.012 14.9 0.4 1.2 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 AAS50827.2 - 0.017 14.4 0.2 0.029 13.6 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AAS50827.2 - 0.033 12.9 0.9 0.05 12.3 0.9 1.3 1 0 0 1 1 1 0 HI0933-like protein GIDA PF01134.22 AAS50827.2 - 0.039 13.0 2.3 0.072 12.2 2.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 AAS50827.2 - 0.12 11.7 0.2 0.2 10.9 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AAS50827.2 - 0.22 10.5 1.8 0.29 10.2 0.8 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein Pyr_redox PF00070.27 AAS50827.2 - 0.33 11.5 3.1 0.49 11.0 1.1 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Copper-fist PF00649.18 AAS50828.2 - 3.6e-21 74.4 2.0 1.1e-20 72.8 2.0 1.9 1 0 0 1 1 1 1 Copper fist DNA binding domain UQ_con PF00179.26 AAS50829.1 - 4.4e-49 165.7 0.0 4.9e-49 165.6 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Glyco_hydro_76 PF03663.14 AAS50830.2 - 2.4e-155 517.6 16.0 2.8e-155 517.4 16.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 DUF2347 PF09804.9 AAS50831.2 - 6e-82 275.4 0.0 7.5e-82 275.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) Avl9 PF09794.9 AAS50831.2 - 5.9e-09 35.1 0.0 0.00048 18.9 0.0 2.2 2 0 0 2 2 2 2 Transport protein Avl9 DUF4484 PF14831.6 AAS50831.2 - 2.6e-06 27.7 6.9 0.00078 19.5 0.0 3.2 1 1 2 3 3 3 3 Domain of unknown function (DUF4484) SPA PF08616.10 AAS50831.2 - 1.2e-05 25.2 0.0 2.5e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Stabilization of polarity axis BLI1 PF17324.2 AAS50832.1 - 1e-28 100.2 1.1 1.1e-28 100.0 1.1 1.0 1 0 0 1 1 1 1 BLOC-1 interactor 1 Apolipoprotein PF01442.18 AAS50832.1 - 0.001 19.0 2.5 0.0022 17.9 2.5 1.5 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain BLOC1_2 PF10046.9 AAS50832.1 - 0.0045 17.3 1.6 0.0067 16.7 0.5 1.8 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF812 PF05667.11 AAS50832.1 - 0.0066 15.4 2.0 0.0077 15.2 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) HBM PF16591.5 AAS50832.1 - 0.0079 15.7 1.4 0.14 11.6 0.2 2.0 1 1 1 2 2 2 1 Helical bimodular sensor domain Cor1 PF04803.12 AAS50832.1 - 0.015 15.5 1.0 0.028 14.6 0.2 1.8 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region DUF4351 PF14261.6 AAS50832.1 - 0.02 15.0 1.9 0.57 10.3 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4351) GyrB_insert PF18053.1 AAS50832.1 - 0.036 13.9 0.4 0.046 13.6 0.4 1.1 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain DASH_Dam1 PF08653.10 AAS50832.1 - 0.059 13.2 0.2 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 DASH complex subunit Dam1 Baculo_PEP_C PF04513.12 AAS50832.1 - 0.078 13.0 0.2 0.82 9.7 0.1 2.0 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DOG1 PF14144.6 AAS50832.1 - 0.091 13.0 0.2 0.21 11.8 0.1 1.7 1 1 1 2 2 2 0 Seed dormancy control DASH_Dad2 PF08654.10 AAS50832.1 - 0.13 12.6 1.3 0.44 11.0 0.3 2.2 2 1 0 2 2 2 0 DASH complex subunit Dad2 SgrT PF15894.5 AAS50832.1 - 0.14 12.2 0.0 0.3 11.1 0.0 1.6 1 1 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT SlyX PF04102.12 AAS50832.1 - 0.18 12.4 2.8 1.5 9.5 0.4 2.4 2 0 0 2 2 2 0 SlyX MnmE_helical PF12631.7 AAS50833.3 - 2.2e-41 142.3 0.2 2.8e-41 142.0 0.2 1.1 1 0 0 1 1 1 1 MnmE helical domain TrmE_N PF10396.9 AAS50833.3 - 2.3e-34 118.1 0.0 6e-34 116.8 0.0 1.7 2 0 0 2 2 2 1 GTP-binding protein TrmE N-terminus MMR_HSR1 PF01926.23 AAS50833.3 - 2.5e-20 72.6 0.0 6.5e-20 71.3 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS50833.3 - 2.2e-10 40.3 0.0 3.3e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 AAS50833.3 - 1.8e-05 24.4 0.0 0.0029 17.2 0.0 2.4 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS50833.3 - 0.00041 20.3 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 AAS50833.3 - 0.0011 19.0 0.3 0.0083 16.2 0.1 2.1 1 1 1 2 2 2 1 Dynamin family cobW PF02492.19 AAS50833.3 - 0.0017 18.0 0.0 0.0074 15.9 0.0 1.8 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 AAS50833.3 - 0.038 14.0 0.0 0.1 12.6 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Ras PF00071.22 AAS50833.3 - 0.19 11.3 0.0 0.41 10.2 0.0 1.6 1 1 0 1 1 1 0 Ras family dsrm PF00035.26 AAS50835.2 - 3e-08 34.2 0.0 5.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ribonuclease_3 PF00636.26 AAS50835.2 - 0.0015 19.1 0.0 0.0033 18.0 0.0 1.6 1 1 0 1 1 1 1 Ribonuclease III domain Met_10 PF02475.16 AAS50836.2 - 0.00062 19.6 0.0 0.00099 18.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein MitMem_reg PF13012.6 AAS50836.2 - 0.0059 17.0 0.0 0.0097 16.3 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Pex2_Pex12 PF04757.14 AAS50837.1 - 3.8e-40 137.9 3.8 4.5e-40 137.6 3.8 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4_3 PF13920.6 AAS50837.1 - 1.7e-06 27.8 1.3 2.7e-06 27.1 1.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS50837.1 - 0.00049 19.9 0.7 0.00089 19.1 0.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS50837.1 - 0.0058 16.9 0.7 0.011 16.1 0.7 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AAS50837.1 - 0.023 14.6 0.7 0.038 13.9 0.7 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AAS50837.1 - 0.026 14.7 2.9 0.048 13.8 2.9 1.4 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING APH PF01636.23 AAS50837.1 - 0.027 14.4 1.2 0.044 13.7 1.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family zf-RING_UBOX PF13445.6 AAS50837.1 - 0.086 12.9 2.5 0.15 12.1 2.5 1.4 1 0 0 1 1 1 0 RING-type zinc-finger F_bP_aldolase PF01116.20 AAS50838.2 - 3.9e-92 308.7 0.1 4.4e-92 308.5 0.1 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-II DUF89 PF01937.19 AAS50839.1 - 4.4e-114 381.1 0.0 5.1e-114 380.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DWNN PF08783.11 AAS50840.2 - 5.3e-30 103.5 0.1 1.3e-29 102.3 0.0 1.7 2 0 0 2 2 2 1 DWNN domain zf-CCHC_2 PF13696.6 AAS50840.2 - 9.9e-09 34.9 7.1 3.3e-07 30.0 7.0 2.3 2 0 0 2 2 2 1 Zinc knuckle U-box PF04564.15 AAS50840.2 - 2.9e-05 24.2 0.0 0.00019 21.5 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-CCHC PF00098.23 AAS50840.2 - 0.00075 19.5 3.3 0.0016 18.4 3.3 1.5 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 AAS50840.2 - 0.019 14.9 0.1 0.034 14.1 0.1 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-Nse PF11789.8 AAS50840.2 - 0.047 13.5 0.2 0.13 12.1 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Rubredoxin PF00301.20 AAS50840.2 - 3.5 7.7 11.6 2.4 8.2 0.1 3.2 4 0 0 4 4 4 0 Rubredoxin zf-CCHC_5 PF14787.6 AAS50840.2 - 6.3 6.6 6.3 0.26 11.0 0.5 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger TFIIA_gamma_C PF02751.14 AAS50841.2 - 1.8e-23 82.4 0.3 2.7e-23 81.9 0.3 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFIIA_gamma_N PF02268.16 AAS50841.2 - 6.8e-23 80.4 0.3 9e-23 80.0 0.3 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TAP42 PF04177.12 AAS50842.2 - 2.9e-79 266.5 2.9 3.4e-79 266.3 2.9 1.0 1 0 0 1 1 1 1 TAP42-like family Cas9-BH PF16593.5 AAS50842.2 - 0.019 14.7 3.0 0.063 13.0 3.0 1.9 1 0 0 1 1 1 0 Bridge helix of CRISPR-associated endonuclease Cas9 Nup160 PF11715.8 AAS50843.2 - 4.2e-26 91.7 1.8 7.9e-26 90.8 1.8 1.4 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC3 PF12895.7 AAS50843.2 - 0.0028 17.9 0.1 0.0082 16.4 0.1 1.8 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 AAS50843.2 - 0.0037 17.3 0.7 0.013 15.6 0.7 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS50843.2 - 0.069 13.0 0.3 0.069 13.0 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50843.2 - 1.9 8.9 5.9 0.46 10.8 0.5 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Striatin PF08232.12 AAS50844.2 - 4e-20 73.0 2.2 8.3e-20 72.0 0.9 2.1 1 1 1 2 2 2 1 Striatin family Mto2_bdg PF12808.7 AAS50844.2 - 0.014 15.6 2.0 0.035 14.4 2.0 1.6 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region Herpes_BLRF2 PF05812.12 AAS50844.2 - 0.034 14.3 0.2 0.083 13.0 0.2 1.7 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein TCTP PF00838.17 AAS50845.2 - 6.1e-73 244.6 1.0 6.8e-73 244.5 1.0 1.0 1 0 0 1 1 1 1 Translationally controlled tumour protein adh_short PF00106.25 AAS50846.2 - 1.7e-33 115.8 0.1 8.1e-24 84.2 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AAS50846.2 - 4e-20 72.4 0.5 1e-17 64.5 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 AAS50846.2 - 0.19 11.2 0.7 7.2 6.0 0.0 2.4 2 1 0 2 2 2 0 NAD dependent epimerase/dehydratase family UPF0203 PF05254.12 AAS50848.1 - 2.8e-27 94.8 1.7 3.2e-27 94.6 1.7 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 AAS50848.1 - 3.7e-06 27.0 0.3 5.3e-06 26.5 0.3 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase hinge protein EcoEI_R_C PF08463.10 AAS50848.1 - 0.0064 16.6 0.0 0.0072 16.5 0.0 1.0 1 0 0 1 1 1 1 EcoEI R protein C-terminal Cmc1 PF08583.10 AAS50848.1 - 0.03 14.3 1.0 0.22 11.5 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 AAS50848.1 - 0.18 12.1 2.0 13 6.2 0.2 2.2 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 DASH_Ask1 PF08655.10 AAS50849.1 - 1.3e-27 95.5 0.2 2.1e-27 94.8 0.2 1.4 1 0 0 1 1 1 1 DASH complex subunit Ask1 Frag1 PF10277.9 AAS50850.2 - 1.2e-82 276.7 23.0 1.4e-82 276.4 23.0 1.0 1 0 0 1 1 1 1 Frag1/DRAM/Sfk1 family Eisosome1 PF12757.7 AAS50851.1 - 1.1e-28 100.0 7.7 1.1e-28 100.0 7.7 3.5 3 1 0 3 3 3 1 Eisosome protein 1 FCH PF00611.23 AAS50852.2 - 4.7e-13 49.2 1.9 8.1e-13 48.5 0.3 2.3 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_9 PF14604.6 AAS50852.2 - 2e-07 30.7 0.0 9.3e-07 28.6 0.0 2.0 2 0 0 2 2 2 1 Variant SH3 domain SH3_1 PF00018.28 AAS50852.2 - 4.9e-07 29.3 0.0 1.1e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS50852.2 - 2.3e-06 27.2 0.0 6.5e-06 25.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain IBB PF01749.20 AAS50852.2 - 0.02 15.3 0.3 0.02 15.3 0.3 3.2 3 0 0 3 3 3 0 Importin beta binding domain CBP4 PF07960.11 AAS50852.2 - 0.28 11.0 0.0 0.28 11.0 0.0 4.1 4 1 1 5 5 5 0 CBP4 GCN5L1 PF06320.13 AAS50852.2 - 0.76 9.9 7.5 6.1 7.0 4.8 2.9 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Histone PF00125.24 AAS50853.2 - 1.4e-38 132.2 5.0 1.4e-38 132.2 5.0 1.7 1 1 0 2 2 2 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AAS50853.2 - 0.0031 17.6 2.1 0.0058 16.7 0.2 2.1 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AAS50853.2 - 0.0075 16.6 0.2 0.021 15.2 0.2 1.7 2 0 0 2 2 2 1 CENP-S protein CBFD_NFYB_HMF PF00808.23 AAS50853.2 - 0.1 12.9 0.3 0.74 10.1 0.0 2.3 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Actin PF00022.19 AAS50854.1 - 4.9e-21 74.8 0.0 2.8e-19 69.0 0.0 2.7 2 1 0 2 2 2 2 Actin FtsA PF14450.6 AAS50854.1 - 0.16 12.4 0.1 0.33 11.4 0.1 1.7 1 1 0 1 1 1 0 Cell division protein FtsA SBF_like PF13593.6 AAS50855.2 - 1.3e-110 369.7 17.6 1.5e-110 369.4 17.6 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 AAS50855.2 - 2.2e-08 34.0 11.3 4.6e-08 33.0 11.3 1.6 1 0 0 1 1 1 1 Sodium Bile acid symporter family Peptidase_S24 PF00717.23 AAS50856.1 - 6.2e-09 35.7 0.1 1.4e-08 34.5 0.1 1.6 1 1 0 1 1 1 1 Peptidase S24-like Peptidase_S26 PF10502.9 AAS50856.1 - 2.4e-05 24.1 0.0 0.0014 18.5 0.0 2.1 1 1 1 2 2 2 2 Signal peptidase, peptidase S26 Rhodanese PF00581.20 AAS50857.2 - 4.4e-11 43.2 0.0 8.7e-11 42.3 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Pkinase PF00069.25 AAS50858.2 - 5.5e-32 111.2 0.0 6.6e-29 101.1 0.0 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50858.2 - 7.1e-18 64.8 0.0 6.1e-12 45.4 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.6 AAS50858.2 - 2.9e-05 23.5 0.0 0.25 10.6 0.0 2.3 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 AAS50858.2 - 0.00063 19.7 0.0 0.0011 18.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AAS50858.2 - 0.0098 14.7 0.0 0.019 13.8 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase zf-C2H2 PF00096.26 AAS50859.2 - 5.4e-13 48.6 13.2 3e-06 27.4 3.3 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS50859.2 - 2.6e-09 37.1 12.3 9.5e-05 22.9 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS50859.2 - 5.7e-08 32.8 18.7 2e-06 28.0 3.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS50859.2 - 7.8e-07 29.2 8.9 0.001 19.3 2.2 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 AAS50859.2 - 5.3e-05 23.1 5.7 0.041 13.9 1.0 2.5 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_6 PF13912.6 AAS50859.2 - 0.00013 21.9 12.7 0.00033 20.6 3.3 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2HE PF16278.5 AAS50859.2 - 0.0022 18.4 8.9 0.32 11.5 0.9 2.6 1 1 1 2 2 2 2 C2HE / C2H2 / C2HC zinc-binding finger zf-Di19 PF05605.12 AAS50859.2 - 0.071 13.4 3.7 0.2 12.0 3.7 1.9 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 AAS50859.2 - 0.099 13.0 6.1 0.46 10.9 0.4 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 AAS50859.2 - 0.11 12.9 5.0 1.1 9.8 0.7 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type HYLS1_C PF15311.6 AAS50859.2 - 0.14 12.9 0.3 10 7.0 0.1 2.6 2 0 0 2 2 2 0 Hydrolethalus syndrome protein 1 C-terminus GAGA PF09237.11 AAS50859.2 - 0.22 11.3 2.6 5.8 6.8 0.9 2.5 1 1 1 2 2 2 0 GAGA factor zf_C2H2_ZHX PF18387.1 AAS50859.2 - 0.28 10.9 4.2 2 8.1 0.3 2.4 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-AN1 PF01428.16 AAS50859.2 - 0.28 11.4 2.3 20 5.4 0.1 2.5 2 0 0 2 2 2 0 AN1-like Zinc finger zf-C2H2_3rep PF18868.1 AAS50859.2 - 0.42 11.3 3.4 0.63 10.7 1.2 2.4 2 1 0 2 2 1 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_11 PF16622.5 AAS50859.2 - 0.6 9.9 4.5 2.2 8.1 0.3 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type PyrI_C PF02748.15 AAS50859.2 - 1.6 8.7 3.7 0.87 9.5 0.2 2.0 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain HNH PF01844.23 AAS50859.2 - 2.1 8.6 6.0 5 7.4 0.8 2.4 2 0 0 2 2 2 0 HNH endonuclease zf-H2C2_5 PF13909.6 AAS50859.2 - 2.3 8.1 20.7 0.13 12.0 3.2 3.3 2 1 0 2 2 2 0 C2H2-type zinc-finger domain HMA PF00403.26 AAS50861.1 - 2e-11 44.2 0.0 3.2e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Heavy-metal-associated domain FeS_assembly_P PF01883.19 AAS50861.1 - 0.039 14.1 0.0 13 6.0 0.0 2.4 2 0 0 2 2 2 0 Iron-sulfur cluster assembly protein Sod_Cu PF00080.20 AAS50861.1 - 0.044 13.9 0.0 0.068 13.3 0.0 1.3 1 0 0 1 1 1 0 Copper/zinc superoxide dismutase (SODC) CorA PF01544.18 AAS50862.2 - 2.6e-36 125.5 10.6 1.4e-22 80.4 1.0 3.4 4 0 0 4 4 4 3 CorA-like Mg2+ transporter protein PC4 PF02229.16 AAS50863.2 - 1.9e-23 81.8 0.1 2.9e-23 81.2 0.1 1.3 1 0 0 1 1 1 1 Transcriptional Coactivator p15 (PC4) Aldo_ket_red PF00248.21 AAS50864.1 - 6.8e-48 163.3 0.0 8.5e-48 163.0 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Bap31 PF05529.12 AAS50865.2 - 7.1e-23 81.0 1.9 9.2e-23 80.6 1.9 1.2 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 AAS50865.2 - 0.99 9.5 5.6 0.18 11.8 2.2 1.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain NDK PF00334.19 AAS50866.2 - 5.1e-55 185.2 0.0 5.8e-55 185.0 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase PWWP PF00855.17 AAS50867.2 - 8.9e-19 67.7 1.9 1.2e-18 67.3 0.1 2.1 2 0 0 2 2 2 1 PWWP domain SRF-TF PF00319.18 AAS50868.2 - 7.2e-21 73.4 0.1 1.1e-20 72.9 0.1 1.3 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) TFIIE-A_C PF11521.8 AAS50868.2 - 0.038 14.3 2.0 0.038 14.3 2.0 2.1 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha Nucleoporin_FG PF13634.6 AAS50869.2 - 5.1e-48 161.9 358.8 6.1e-11 43.0 43.1 12.0 2 2 9 11 11 11 11 Nucleoporin FG repeat region Nucleoporin2 PF04096.14 AAS50869.2 - 1.5e-32 112.8 0.0 2.4e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin autopeptidase Swi3 PF07962.12 AAS50871.1 - 7.9e-29 99.5 0.4 1.2e-28 98.9 0.4 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 BOP1NT PF08145.12 AAS50872.2 - 3.4e-105 351.6 4.9 5.9e-105 350.9 4.9 1.4 1 0 0 1 1 1 1 BOP1NT (NUC169) domain WD40 PF00400.32 AAS50872.2 - 1.2e-23 82.9 5.8 3.3e-09 37.2 0.2 6.5 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS50872.2 - 2.6e-06 27.7 1.0 0.033 14.5 0.0 5.1 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DUF287 PF03384.14 AAS50872.2 - 0.0064 16.9 0.1 0.032 14.6 0.1 2.2 1 0 0 1 1 1 1 Drosophila protein of unknown function, DUF287 Sec7 PF01369.20 AAS50873.2 - 2.1e-27 96.0 0.3 3.7e-27 95.2 0.3 1.3 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 AAS50873.2 - 6.5e-06 26.6 0.0 1.7e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 AAS50873.2 - 0.0013 19.1 0.1 0.01 16.2 0.1 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PHF5 PF03660.14 AAS50874.1 - 8e-51 170.6 11.7 8.9e-51 170.5 11.7 1.0 1 0 0 1 1 1 1 PHF5-like protein DZR PF12773.7 AAS50874.1 - 4.6 7.3 16.7 17 5.6 2.1 2.9 1 1 1 2 2 2 0 Double zinc ribbon PolC_DP2 PF03833.13 AAS50874.1 - 5.2 4.8 8.2 6.1 4.6 8.2 1.3 1 1 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-RING_2 PF13639.6 AAS50875.1 - 1.8e-12 47.4 25.4 1.1e-09 38.5 6.5 2.8 2 0 0 2 2 2 2 Ring finger domain zf-RING_11 PF17123.5 AAS50875.1 - 1.3e-07 31.3 1.0 1.3e-07 31.3 1.0 3.5 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4 PF00097.25 AAS50875.1 - 4.8e-07 29.5 3.5 4.8e-07 29.5 3.5 3.2 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS50875.1 - 1.4e-06 28.1 23.4 1.7e-06 27.9 3.5 2.8 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AAS50875.1 - 3.2e-06 26.9 4.9 3.2e-06 26.9 4.9 3.0 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS50875.1 - 2.3e-05 24.1 2.9 2.3e-05 24.1 2.9 2.8 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AAS50875.1 - 4.7e-05 23.3 16.3 0.00021 21.3 5.2 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AAS50875.1 - 5.2e-05 23.5 9.9 5.2e-05 23.5 9.9 3.5 2 2 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 AAS50875.1 - 7.2e-05 22.7 17.2 0.00015 21.7 3.1 3.3 2 2 1 3 3 3 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 AAS50875.1 - 0.012 15.2 7.3 0.012 15.2 7.3 2.7 2 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type EAV_GS PF01309.18 AAS50875.1 - 0.015 14.9 0.1 0.027 14.1 0.1 1.3 1 0 0 1 1 1 0 Equine arteritis virus small envelope glycoprotein THP2 PF09432.10 AAS50875.1 - 0.024 14.7 0.4 0.05 13.6 0.4 1.5 1 0 0 1 1 1 0 Tho complex subunit THP2 Herpes_UL87 PF03043.14 AAS50875.1 - 0.04 12.4 0.1 0.068 11.6 0.1 1.3 1 0 0 1 1 1 0 Herpesvirus UL87 family Nefa_Nip30_N PF10187.9 AAS50875.1 - 0.063 13.6 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 N-terminal domain of NEFA-interacting nuclear protein NIP30 FANCL_C PF11793.8 AAS50875.1 - 5.5 7.2 22.4 12 6.1 6.2 3.4 2 1 0 2 2 2 0 FANCL C-terminal domain Cofilin_ADF PF00241.20 AAS50876.2 - 6.6e-30 103.4 0.0 2.8e-14 53.0 0.0 2.2 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein MMM1 PF10296.9 AAS50878.2 - 1.1e-08 34.5 0.1 1.1e-08 34.5 0.1 1.7 2 0 0 2 2 2 1 Maintenance of mitochondrial morphology protein 1 PH_11 PF15413.6 AAS50878.2 - 5.4e-06 26.8 0.0 2.7e-05 24.5 0.0 2.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AAS50878.2 - 0.00017 22.1 0.2 0.00076 20.0 0.2 2.2 1 1 0 1 1 1 1 PH domain PI3_PI4_kinase PF00454.27 AAS50879.2 - 1.6e-53 182.1 0.2 3.2e-53 181.1 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase UME PF08064.13 AAS50879.2 - 1.2e-26 92.6 0.4 6.8e-26 90.2 0.4 2.5 1 0 0 1 1 1 1 UME (NUC010) domain FATC PF02260.20 AAS50879.2 - 5.5e-14 51.7 0.3 1.6e-13 50.2 0.3 1.9 1 0 0 1 1 1 1 FATC domain FAT PF02259.23 AAS50879.2 - 4.9e-08 32.6 1.7 4.9e-08 32.6 1.7 2.0 2 0 0 2 2 2 1 FAT domain CKS PF01111.19 AAS50880.1 - 8.4e-34 115.7 0.1 1.1e-33 115.3 0.1 1.2 1 0 0 1 1 1 1 Cyclin-dependent kinase regulatory subunit eIF-1a PF01176.19 AAS50880.1 - 0.17 11.7 0.0 1.2 9.0 0.0 2.0 2 0 0 2 2 2 0 Translation initiation factor 1A / IF-1 PRMT5_C PF17286.2 AAS50881.2 - 5.9e-64 215.2 0.0 9.5e-64 214.5 0.0 1.3 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 AAS50881.2 - 7.1e-60 202.3 0.0 1.3e-59 201.5 0.0 1.4 1 0 0 1 1 1 1 PRMT5 TIM barrel domain PRMT5 PF05185.16 AAS50881.2 - 1.4e-59 200.8 0.0 1.4e-59 200.8 0.0 2.0 3 0 0 3 3 3 1 PRMT5 arginine-N-methyltransferase K_channel_TID PF07941.11 AAS50881.2 - 0.44 11.0 4.0 0.88 10.1 4.0 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DIL PF01843.19 AAS50882.2 - 2e-20 73.0 3.4 5.7e-19 68.3 3.4 2.8 1 1 0 1 1 1 1 DIL domain Ank_2 PF12796.7 AAS50882.2 - 0.014 16.0 0.0 0.1 13.2 0.0 2.1 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AAS50882.2 - 0.068 13.8 0.1 2 9.1 0.1 2.8 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF2875 PF11394.8 AAS50882.2 - 0.082 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2875) Not1 PF04054.15 AAS50883.2 - 9.5e-131 436.1 4.9 9.5e-131 436.1 4.9 4.1 3 0 0 3 3 3 1 CCR4-Not complex component, Not1 CNOT1_CAF1_bind PF16415.5 AAS50883.2 - 2.8e-88 295.1 3.8 2.8e-88 295.1 3.8 2.7 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_HEAT_N PF16419.5 AAS50883.2 - 2.1e-86 289.3 6.2 2.1e-86 289.3 6.2 2.9 3 0 0 3 3 3 1 CCR4-NOT transcription complex subunit 1 HEAT repeat CNOT1_TTP_bind PF16417.5 AAS50883.2 - 4e-41 140.3 0.3 4e-41 140.3 0.3 4.7 4 1 0 4 4 4 1 CCR4-NOT transcription complex subunit 1 TTP binding domain DUF3819 PF12842.7 AAS50883.2 - 7.1e-41 139.6 6.7 7.1e-41 139.6 6.7 4.1 4 1 0 4 4 4 1 Domain of unknown function (DUF3819) CNOT1_HEAT PF16418.5 AAS50883.2 - 2.1e-16 60.3 0.1 2.1e-16 60.3 0.1 5.4 5 1 0 5 5 5 1 CCR4-NOT transcription complex subunit 1 HEAT repeat DUF2420 PF10336.9 AAS50883.2 - 0.00082 19.4 0.2 0.0059 16.6 0.2 2.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) TFIIA PF03153.13 AAS50883.2 - 0.00089 19.4 51.9 0.00089 19.4 51.9 2.7 3 0 0 3 3 3 2 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 AAS50883.2 - 1.4 7.6 34.3 0.017 13.9 25.6 2.0 2 0 0 2 2 2 0 Presenilin Band_3_cyto PF07565.13 AAS50883.2 - 3.6 7.3 27.3 0.49 10.2 18.7 2.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain MFS_1 PF07690.16 AAS50884.2 - 8.7e-17 61.1 18.1 8.7e-17 61.1 18.1 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily Hydantoinase_B PF02538.14 AAS50885.1 - 2.1e-205 683.0 0.1 2.8e-205 682.6 0.1 1.1 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase Hydantoinase_A PF01968.18 AAS50885.1 - 6.6e-104 347.2 0.0 6.6e-104 347.2 0.0 1.5 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 AAS50885.1 - 1.2e-57 194.5 0.0 1.3e-55 187.9 0.0 2.6 2 0 0 2 2 2 2 Hydantoinase/oxoprolinase N-terminal region Mso1_Sec1_bdg PF14475.6 AAS50886.2 - 9.5e-15 53.9 0.1 1.7e-14 53.1 0.1 1.4 1 0 0 1 1 1 1 Sec1-binding region of Mso1 Sacchrp_dh_C PF16653.5 AAS50887.1 - 8e-91 304.8 0.0 1e-90 304.4 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 AAS50887.1 - 3.3e-25 88.8 1.1 5e-25 88.2 1.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AAS50887.1 - 1.7e-05 24.9 0.2 0.00014 21.9 0.1 2.0 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.6 AAS50887.1 - 7.9e-05 22.6 3.6 7.9e-05 22.6 3.6 1.8 2 1 0 2 2 2 1 NAD(P)H-binding F420_oxidored PF03807.17 AAS50887.1 - 0.023 15.2 0.5 0.054 14.1 0.5 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GFO_IDH_MocA PF01408.22 AAS50887.1 - 0.026 15.4 1.2 0.038 14.8 0.3 1.7 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 AAS50887.1 - 0.15 12.2 1.6 0.21 11.7 0.7 1.7 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Y_phosphatase2 PF03162.13 AAS50888.4 - 4.9e-33 114.0 1.5 3e-31 108.2 1.5 2.2 1 1 0 1 1 1 1 Tyrosine phosphatase family DUF3750 PF12570.8 AAS50888.4 - 0.079 13.7 0.0 2.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3750) NTF2 PF02136.20 AAS50889.2 - 2.2e-20 73.4 0.1 4.4e-20 72.4 0.1 1.5 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain RRM_1 PF00076.22 AAS50889.2 - 0.0024 17.7 0.0 0.007 16.2 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HC2 PF07382.11 AAS50889.2 - 0.015 15.4 30.8 0.038 14.1 30.8 1.7 1 1 0 1 1 1 0 Histone H1-like nucleoprotein HC2 bVLRF1 PF18826.1 AAS50889.2 - 0.051 13.4 1.1 0.12 12.3 1.1 1.5 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor CAF1 PF04857.20 AAS50890.2 - 1.2e-11 44.4 0.2 3.9e-07 29.6 0.0 2.1 2 0 0 2 2 2 2 CAF1 family ribonuclease NGP1NT PF08153.12 AAS50891.1 - 6.7e-52 175.1 0.0 1.1e-51 174.4 0.0 1.3 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MMR_HSR1 PF01926.23 AAS50891.1 - 1e-17 64.3 0.0 1.5e-13 50.8 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS50891.1 - 1.7e-05 24.4 0.0 7.8e-05 22.2 0.0 1.9 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AAS50891.1 - 0.001 19.1 0.1 0.84 9.7 0.0 3.3 2 1 1 3 3 3 1 Dynamin family Arf PF00025.21 AAS50891.1 - 0.002 17.6 0.1 0.25 10.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 AAS50891.1 - 0.003 17.5 0.0 0.0072 16.2 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 AAS50891.1 - 0.0043 16.6 0.2 0.43 10.1 0.1 3.3 2 2 0 3 3 3 1 Elongation factor Tu GTP binding domain Glyco_hydro_125 PF06824.11 AAS50891.1 - 0.082 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Metal-independent alpha-mannosidase (GH125) RRM_1 PF00076.22 AAS50892.1 - 0.00072 19.3 0.0 0.1 12.4 0.0 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SOR_SNZ PF01680.17 AAS50893.2 - 4e-104 346.9 3.8 5.3e-104 346.5 3.8 1.1 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 AAS50893.2 - 5.8e-08 32.4 2.5 1.5e-06 27.8 0.1 2.5 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Dus PF01207.17 AAS50893.2 - 0.002 17.3 0.7 1.5 7.8 0.0 2.8 2 1 1 3 3 3 2 Dihydrouridine synthase (Dus) TMP-TENI PF02581.17 AAS50893.2 - 0.0079 15.5 0.6 0.11 11.9 0.1 2.4 2 1 0 2 2 2 1 Thiamine monophosphate synthase NanE PF04131.14 AAS50893.2 - 0.012 14.8 0.4 0.21 10.8 0.0 2.3 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase TetR_C_27 PF17935.1 AAS50893.2 - 0.012 15.6 0.0 0.028 14.5 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain His_biosynth PF00977.21 AAS50893.2 - 0.023 14.2 0.1 0.19 11.1 0.0 2.1 2 0 0 2 2 2 0 Histidine biosynthesis protein IGPS PF00218.21 AAS50893.2 - 0.04 13.1 0.1 0.21 10.7 0.0 2.1 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase 1-cysPrx_C PF10417.9 AAS50893.2 - 0.1 12.5 0.2 5.4 6.9 0.0 2.6 2 0 0 2 2 2 0 C-terminal domain of 1-Cys peroxiredoxin SNO PF01174.19 AAS50894.1 - 2.2e-72 242.9 0.0 2.9e-72 242.5 0.0 1.1 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 AAS50894.1 - 1.8e-10 40.8 0.0 3.1e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AAS50894.1 - 3.3e-05 23.7 0.0 5.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I ThiJ_like PF17124.5 AAS50894.1 - 0.0044 16.7 0.0 0.0062 16.2 0.0 1.2 1 0 0 1 1 1 1 ThiJ/PfpI family-like DJ-1_PfpI PF01965.24 AAS50894.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family Peptidase_S51 PF03575.17 AAS50894.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Peptidase family S51 Transp_cyt_pur PF02133.15 AAS50895.1 - 5.5e-145 483.5 38.1 6.3e-145 483.3 38.1 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin SAYSvFN PF10260.9 AAS50895.1 - 0.088 12.7 7.9 1.8 8.6 0.1 3.8 3 0 0 3 3 3 0 Uncharacterized conserved domain (SAYSvFN) ABC2_membrane PF01061.24 AAS50896.3 - 1.3e-65 220.7 57.1 5.3e-35 120.8 21.0 2.4 2 0 0 2 2 2 2 ABC-2 type transporter ABC_tran PF00005.27 AAS50896.3 - 7.6e-40 136.6 0.0 1.1e-18 68.1 0.0 2.6 2 0 0 2 2 2 2 ABC transporter PDR_CDR PF06422.12 AAS50896.3 - 8.9e-39 131.3 2.1 3.2e-31 107.1 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC2_membrane_3 PF12698.7 AAS50896.3 - 6.3e-11 42.0 43.8 6.8e-08 32.0 13.9 2.5 2 1 0 2 2 2 2 ABC-2 family transporter protein RsgA_GTPase PF03193.16 AAS50896.3 - 4e-06 26.8 0.0 0.00022 21.2 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 AAS50896.3 - 6.8e-06 26.6 0.5 0.0096 16.3 0.1 2.7 2 1 0 2 2 2 2 AAA ATPase domain ABC_trans_N PF14510.6 AAS50896.3 - 3.4e-05 24.4 0.0 0.00033 21.2 0.0 2.3 2 0 0 2 2 2 1 ABC-transporter N-terminal AAA_22 PF13401.6 AAS50896.3 - 9.1e-05 22.7 0.0 0.01 16.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain AAA_21 PF13304.6 AAS50896.3 - 0.00037 20.4 0.0 0.8 9.5 0.0 2.4 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system cobW PF02492.19 AAS50896.3 - 0.00079 19.0 0.5 0.0093 15.6 0.1 2.2 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain SMC_N PF02463.19 AAS50896.3 - 0.001 18.6 0.0 0.14 11.6 0.0 3.2 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_18 PF13238.6 AAS50896.3 - 0.0017 18.9 0.0 0.11 13.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain MMR_HSR1 PF01926.23 AAS50896.3 - 0.0023 18.0 0.2 0.15 12.2 0.1 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase NACHT PF05729.12 AAS50896.3 - 0.013 15.4 0.3 0.5 10.3 0.1 2.5 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 AAS50896.3 - 0.014 15.8 0.0 3.6 8.0 0.0 3.1 3 0 0 3 3 3 0 RNA helicase AAA PF00004.29 AAS50896.3 - 0.022 15.2 0.0 11 6.4 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AAS50896.3 - 0.023 14.4 0.3 0.23 11.2 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_25 PF13481.6 AAS50896.3 - 0.03 13.9 0.1 0.1 12.1 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_30 PF13604.6 AAS50896.3 - 0.045 13.5 0.7 3.5 7.3 0.1 2.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AAS50896.3 - 0.046 14.0 0.1 0.27 11.5 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AAS50896.3 - 0.057 13.1 0.0 0.53 10.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 AAS50896.3 - 0.062 13.3 0.5 0.58 10.2 0.3 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DnaB_C PF03796.15 AAS50896.3 - 0.071 12.4 0.0 9.1 5.5 0.0 2.2 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Septin PF00735.18 AAS50896.3 - 0.088 12.1 0.1 0.29 10.4 0.1 1.8 2 0 0 2 2 2 0 Septin PduV-EutP PF10662.9 AAS50896.3 - 0.11 12.2 0.3 3.4 7.4 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 AAS50896.3 - 0.13 11.6 0.0 14 4.9 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 AAS50896.3 - 0.17 12.4 0.1 0.49 10.9 0.0 1.7 2 0 0 2 2 1 0 AAA domain Dynamin_N PF00350.23 AAS50896.3 - 0.17 11.9 0.0 0.39 10.7 0.0 1.6 1 0 0 1 1 1 0 Dynamin family Roc PF08477.13 AAS50896.3 - 0.17 12.1 0.1 3.1 8.0 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase ABC_ATPase PF09818.9 AAS50896.3 - 0.26 10.0 0.5 0.42 9.3 0.5 1.2 1 0 0 1 1 1 0 Predicted ATPase of the ABC class DAGK_prokar PF01219.19 AAS50896.3 - 0.28 11.0 3.6 0.84 9.5 3.6 1.8 1 0 0 1 1 1 0 Prokaryotic diacylglycerol kinase HalX PF08663.10 AAS50896.3 - 1.6 9.1 3.9 1.2 9.5 1.0 2.1 2 0 0 2 2 2 0 HalX domain ABC2_membrane PF01061.24 AAS50897.2 - 3e-78 262.0 58.8 4.8e-44 150.3 21.4 3.6 4 0 0 4 4 4 2 ABC-2 type transporter PDR_CDR PF06422.12 AAS50897.2 - 1.3e-33 114.7 1.5 3.1e-29 100.7 0.0 3.1 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 AAS50897.2 - 3.9e-30 105.2 0.0 3.7e-15 56.6 0.0 2.7 2 0 0 2 2 2 2 ABC transporter ABC_trans_N PF14510.6 AAS50897.2 - 3.1e-14 53.3 0.0 1.1e-13 51.5 0.0 2.0 1 0 0 1 1 1 1 ABC-transporter N-terminal RsgA_GTPase PF03193.16 AAS50897.2 - 1.9e-06 27.9 0.0 0.00066 19.6 0.0 2.6 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 AAS50897.2 - 4.1e-05 24.0 0.3 0.0047 17.3 0.0 2.7 3 0 0 3 3 2 1 AAA ATPase domain AAA_25 PF13481.6 AAS50897.2 - 4.6e-05 23.1 0.3 0.00031 20.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC2_membrane_3 PF12698.7 AAS50897.2 - 0.00013 21.2 45.7 0.019 14.1 22.8 3.4 2 2 1 3 3 3 2 ABC-2 family transporter protein AAA_29 PF13555.6 AAS50897.2 - 0.00044 19.9 0.2 0.02 14.6 0.1 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 AAS50897.2 - 0.0023 18.2 0.2 0.55 10.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AAS50897.2 - 0.0042 17.6 0.0 0.1 13.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AAS50897.2 - 0.0094 16.2 0.6 0.78 10.0 0.1 2.9 2 0 0 2 2 2 1 AAA domain cobW PF02492.19 AAS50897.2 - 0.016 14.8 1.1 0.085 12.4 0.1 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 AAS50897.2 - 0.02 14.6 0.5 3.9 7.1 0.2 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 AAS50897.2 - 0.023 14.5 0.1 2.2 8.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS50897.2 - 0.033 13.6 0.0 1.1 8.6 0.0 2.6 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain dNK PF01712.19 AAS50897.2 - 0.04 13.8 0.0 9.2 6.1 0.0 2.5 2 0 0 2 2 2 0 Deoxynucleoside kinase MMR_HSR1 PF01926.23 AAS50897.2 - 0.064 13.4 0.1 5.9 7.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase NACHT PF05729.12 AAS50897.2 - 0.075 13.0 0.5 1.4 8.8 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_33 PF13671.6 AAS50897.2 - 0.089 12.9 0.2 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AAS50897.2 - 0.12 12.9 2.5 1.1 9.7 0.2 2.9 3 0 0 3 3 3 0 AAA domain OCD_Mu_crystall PF02423.15 AAS50897.2 - 0.17 10.8 0.0 0.29 10.0 0.0 1.3 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family WI12 PF07107.11 AAS50898.2 - 0.0015 18.6 0.0 0.088 12.9 0.0 2.4 2 0 0 2 2 2 1 Wound-induced protein WI12 VWA_N PF08399.11 AAS50898.2 - 0.26 11.8 0.2 0.26 11.8 0.2 1.6 2 0 0 2 2 2 0 VWA N-terminal Cation_efflux PF01545.21 AAS50900.2 - 4.6e-56 189.7 5.0 7.2e-56 189.1 5.0 1.3 1 0 0 1 1 1 1 Cation efflux family PgpA PF04608.13 AAS50900.2 - 0.64 10.0 4.4 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 Phosphatidylglycerophosphatase A CHCH PF06747.13 AAS50901.2 - 9.5e-07 28.8 8.0 1.5e-06 28.2 8.0 1.3 1 0 0 1 1 1 1 CHCH domain MTCP1 PF08991.10 AAS50901.2 - 3.3e-06 27.2 3.1 4.8e-06 26.7 3.1 1.2 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type Pet191_N PF10203.9 AAS50901.2 - 0.0079 16.5 4.0 0.012 15.9 4.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 TAP_C PF03943.13 AAS50901.2 - 0.14 11.8 1.0 0.82 9.4 0.2 2.1 2 0 0 2 2 2 0 TAP C-terminal domain TPR_1 PF00515.28 AAS50902.1 - 6.9e-20 70.0 32.4 5.1e-06 26.1 0.7 11.2 11 0 0 11 11 11 4 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50902.1 - 1.7e-19 68.3 41.3 0.03 14.4 0.4 11.8 10 2 2 12 12 11 6 Tetratricopeptide repeat TPR_16 PF13432.6 AAS50902.1 - 7.4e-19 68.1 16.8 0.00089 19.9 0.1 7.5 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50902.1 - 1.4e-14 54.4 28.4 6.3e-05 23.4 3.9 7.6 6 2 1 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 AAS50902.1 - 1.2e-12 47.5 24.2 0.067 14.0 0.1 9.1 6 3 3 9 9 9 4 Tetratricopeptide repeat TPR_12 PF13424.6 AAS50902.1 - 6.5e-11 42.4 24.4 0.019 15.3 0.6 8.3 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 AAS50902.1 - 1.9e-09 37.0 24.8 0.0054 16.4 0.8 8.4 7 2 2 9 9 9 3 TPR repeat TPR_17 PF13431.6 AAS50902.1 - 8.5e-09 35.2 14.8 0.01 16.2 0.0 7.9 7 1 1 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50902.1 - 6.4e-07 29.1 29.2 0.69 10.3 0.4 9.4 11 0 0 11 11 9 3 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 AAS50902.1 - 0.00028 20.5 0.8 0.15 11.7 0.0 3.7 3 1 1 4 4 4 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 AAS50902.1 - 0.0023 17.8 10.3 2.1 8.6 0.2 5.9 7 0 0 7 7 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 AAS50902.1 - 0.003 17.0 2.8 0.0043 16.5 0.2 2.3 2 0 0 2 2 2 1 MalT-like TPR region ANAPC3 PF12895.7 AAS50902.1 - 0.0057 16.9 19.7 0.11 12.7 0.3 5.4 5 2 1 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 AAS50902.1 - 0.012 15.7 5.3 10 6.3 0.0 4.6 5 0 0 5 5 4 0 Tetratricopeptide repeat Exonuc_VII_S PF02609.16 AAS50902.1 - 0.013 15.6 1.1 0.096 12.8 1.1 2.6 1 0 0 1 1 1 0 Exonuclease VII small subunit DUF2508 PF10704.9 AAS50902.1 - 0.11 12.7 2.1 2.2 8.5 0.4 3.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2508) PknG_TPR PF16918.5 AAS50902.1 - 0.11 11.1 6.3 3.4 6.3 0.4 3.1 2 1 1 3 3 3 0 Protein kinase G tetratricopeptide repeat TPR_21 PF09976.9 AAS50902.1 - 0.15 11.8 21.9 1 9.0 1.7 4.8 3 2 2 5 5 5 0 Tetratricopeptide repeat-like domain PTS_IIA PF02255.16 AAS50902.1 - 0.38 10.8 10.1 5.1 7.2 0.7 4.5 4 1 0 4 4 4 0 PTS system, Lactose/Cellobiose specific IIA subunit TPR_20 PF14561.6 AAS50902.1 - 0.41 11.0 15.3 0.68 10.3 1.1 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 AAS50902.1 - 0.69 10.7 25.8 27 5.7 0.1 8.8 10 0 0 10 10 8 0 Tetratricopeptide repeat TOM20_plant PF06552.12 AAS50902.1 - 0.82 9.4 16.6 9.5 5.9 0.4 4.7 3 1 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 SHNi-TPR PF10516.9 AAS50902.1 - 4.3 6.9 11.2 30 4.2 0.2 5.7 5 0 0 5 5 5 0 SHNi-TPR MIT PF04212.18 AAS50902.1 - 6.1 7.0 22.6 5.4 7.2 0.2 7.4 7 2 1 9 9 9 0 MIT (microtubule interacting and transport) domain Ribosomal_L35p PF01632.19 AAS50904.1 - 1.7e-13 50.8 8.5 2.3e-13 50.4 8.5 1.1 1 0 0 1 1 1 1 Ribosomal protein L35 PDZ_1 PF12812.7 AAS50905.2 - 9.9e-55 182.5 0.4 6.6e-36 122.2 0.0 3.6 3 0 0 3 3 3 2 PDZ-like domain Trypsin_2 PF13365.6 AAS50905.2 - 4.3e-23 82.9 0.8 1.9e-19 71.1 0.1 2.5 2 0 0 2 2 2 2 Trypsin-like peptidase domain PDZ PF00595.24 AAS50905.2 - 1.1e-14 54.6 0.0 2.2e-09 37.5 0.0 3.4 3 0 0 3 3 3 2 PDZ domain PDZ_6 PF17820.1 AAS50905.2 - 1.9e-13 50.1 3.2 4.5e-09 36.0 0.1 3.6 3 0 0 3 3 3 2 PDZ domain PDZ_2 PF13180.6 AAS50905.2 - 3.7e-11 43.2 1.0 0.0015 18.8 0.0 4.4 5 0 0 5 5 5 2 PDZ domain Trypsin PF00089.26 AAS50905.2 - 4.6e-05 23.3 0.0 0.00021 21.1 0.0 2.1 2 0 0 2 2 2 1 Trypsin Tricorn_PDZ PF14685.6 AAS50905.2 - 0.0029 17.6 0.2 0.52 10.3 0.0 3.1 3 0 0 3 3 3 1 Tricorn protease PDZ domain DUF31 PF01732.16 AAS50905.2 - 0.018 14.6 0.1 0.027 14.0 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) ORC6 PF05460.13 AAS50906.1 - 1.1e-109 367.1 0.0 1.3e-109 366.8 0.0 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) N-SET PF11764.8 AAS50907.2 - 4.3e-48 163.7 2.1 4.3e-48 163.7 2.1 2.3 2 0 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component N SET PF00856.28 AAS50907.2 - 7.7e-21 75.2 0.9 3.1e-18 66.7 0.1 3.8 3 1 0 3 3 3 1 SET domain SET_assoc PF11767.8 AAS50907.2 - 9.4e-20 70.0 1.9 1.7e-19 69.2 0.2 2.2 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated CENP-X PF09415.10 AAS50907.2 - 0.14 12.5 0.6 0.59 10.5 0.0 2.4 2 0 0 2 2 2 0 CENP-S associating Centromere protein X MutS_V PF00488.21 AAS50908.2 - 2.7e-66 223.2 0.0 5.3e-66 222.2 0.0 1.5 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AAS50908.2 - 2e-35 122.8 1.2 4.3e-35 121.7 1.2 1.6 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 AAS50908.2 - 1.9e-30 105.4 0.0 1e-29 103.1 0.0 2.2 2 0 0 2 2 2 1 MutS domain I MutS_II PF05188.17 AAS50908.2 - 1e-09 38.8 0.0 2.2e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 MutS domain II ABC_tran PF00005.27 AAS50908.2 - 0.086 13.4 0.3 16 6.0 0.0 3.3 3 0 0 3 3 3 0 ABC transporter AAA_14 PF13173.6 AAS50908.2 - 0.14 12.2 0.0 0.71 9.9 0.0 2.2 1 1 0 1 1 1 0 AAA domain Gar1 PF04410.14 AAS50909.2 - 4.6e-43 146.6 0.3 1e-42 145.5 0.3 1.6 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region AAA PF00004.29 AAS50910.2 - 1.4e-50 171.1 0.0 2.1e-42 144.7 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS50910.2 - 3.7e-10 39.4 0.0 1.3e-09 37.7 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain Sigma54_activ_2 PF14532.6 AAS50910.2 - 1.7e-07 31.4 0.0 0.0048 17.0 0.0 3.0 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_2 PF07724.14 AAS50910.2 - 4.6e-06 26.9 0.0 1.4e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 AAS50910.2 - 4.6e-06 26.5 0.0 7.5e-05 22.5 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_5 PF07728.14 AAS50910.2 - 2.4e-05 24.4 0.0 0.00013 22.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS50910.2 - 2.7e-05 24.6 0.1 0.00059 20.3 0.0 3.2 2 2 0 2 2 2 1 AAA ATPase domain Parvo_NS1 PF01057.17 AAS50910.2 - 0.00075 18.7 0.0 0.12 11.4 0.0 2.3 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Sigma54_activat PF00158.26 AAS50910.2 - 0.0012 18.5 0.0 0.74 9.5 0.0 3.1 2 1 0 2 2 2 1 Sigma-54 interaction domain RNA_helicase PF00910.22 AAS50910.2 - 0.0019 18.5 0.0 0.0076 16.6 0.0 2.1 1 0 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 AAS50910.2 - 0.002 17.7 0.0 0.088 12.3 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 AAS50910.2 - 0.0048 16.6 0.0 0.012 15.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AAS50910.2 - 0.0053 17.3 0.1 0.052 14.1 0.0 2.7 3 0 0 3 3 2 1 ABC transporter Mg_chelatase PF01078.21 AAS50910.2 - 0.0093 15.4 0.1 0.075 12.4 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 AAS50910.2 - 0.011 16.0 0.7 0.18 12.1 0.2 3.1 2 2 1 3 3 3 0 AAA domain Bromodomain PF00439.25 AAS50910.2 - 0.013 15.6 0.2 0.044 13.8 0.1 2.0 2 0 0 2 2 1 0 Bromodomain AAA_25 PF13481.6 AAS50910.2 - 0.015 14.9 0.0 0.038 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 AAS50910.2 - 0.016 14.4 0.0 0.04 13.1 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 AAS50910.2 - 0.018 15.6 0.0 0.12 12.9 0.0 2.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 AAS50910.2 - 0.021 14.6 0.0 0.07 12.9 0.0 1.7 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 AAS50910.2 - 0.024 14.7 0.0 0.073 13.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 AAS50910.2 - 0.027 14.5 0.1 0.14 12.1 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit PhoH PF02562.16 AAS50910.2 - 0.041 13.3 0.0 0.18 11.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_3 PF07726.11 AAS50910.2 - 0.073 12.9 0.0 0.18 11.7 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AAS50910.2 - 0.08 12.6 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 1 0 AAA domain Amidase PF01425.21 AAS50911.2 - 2.7e-124 415.6 0.0 3e-124 415.4 0.0 1.0 1 0 0 1 1 1 1 Amidase Dynamitin PF04912.14 AAS50912.2 - 3.6e-30 105.6 17.4 4e-24 85.7 4.7 2.1 1 1 1 2 2 2 2 Dynamitin BLOC1_2 PF10046.9 AAS50912.2 - 0.0011 19.3 0.6 0.0011 19.3 0.6 3.7 4 2 1 5 5 4 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 STAT_alpha PF01017.20 AAS50912.2 - 0.011 15.7 9.5 0.6 10.0 1.3 3.3 2 1 1 3 3 3 0 STAT protein, all-alpha domain NPV_P10 PF05531.12 AAS50912.2 - 0.035 14.6 4.9 22 5.6 3.1 4.1 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein RPN7 PF10602.9 AAS50912.2 - 0.038 13.7 3.5 0.08 12.6 0.1 2.7 1 1 1 3 3 3 0 26S proteasome subunit RPN7 Nsp1_C PF05064.13 AAS50912.2 - 0.045 13.6 0.4 0.045 13.6 0.4 3.3 3 1 0 3 3 3 0 Nsp1-like C-terminal region Lectin_N PF03954.14 AAS50912.2 - 0.069 12.9 2.1 0.1 12.3 0.8 1.9 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 AAS50912.2 - 0.12 12.4 6.2 1.6 8.8 0.4 4.1 2 1 1 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 AAS50912.2 - 0.15 12.1 4.6 1.3 9.0 0.6 3.1 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 AAS50912.2 - 0.16 12.1 12.5 0.17 12.1 0.6 3.7 3 1 2 5 5 4 0 Fibrinogen alpha/beta chain family TACC_C PF05010.14 AAS50912.2 - 0.35 10.6 12.0 0.038 13.8 6.0 2.4 2 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Neuregulin PF02158.15 AAS50912.2 - 0.5 9.7 3.0 0.22 10.8 0.2 1.7 2 0 0 2 2 2 0 Neuregulin intracellular region CSN5_C PF18323.1 AAS50912.2 - 0.51 11.3 4.7 8.7 7.3 0.1 3.8 2 2 1 3 3 3 0 Cop9 signalosome subunit 5 C-terminal domain EzrA PF06160.12 AAS50912.2 - 0.54 8.4 14.0 0.5 8.5 7.1 2.5 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA DHC PF09626.10 AAS50912.2 - 0.62 11.0 2.1 11 7.0 0.1 2.4 1 1 1 2 2 2 0 Dihaem cytochrome c LMBR1 PF04791.16 AAS50912.2 - 0.82 8.5 1.7 1 8.2 1.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF948 PF06103.11 AAS50912.2 - 0.92 9.8 3.8 10 6.5 2.5 3.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FUSC PF04632.12 AAS50912.2 - 0.93 7.9 7.7 3.8 5.9 0.1 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family FlaC_arch PF05377.11 AAS50912.2 - 0.95 9.9 8.8 18 5.9 0.0 4.8 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) DUF4559 PF15112.6 AAS50912.2 - 1.5 8.4 8.7 0.19 11.4 4.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) YlbD_coat PF14071.6 AAS50912.2 - 2.5 8.4 8.1 0.23 11.7 0.7 2.9 3 1 0 3 3 3 0 Putative coat protein DUF148 PF02520.17 AAS50912.2 - 3.2 7.9 8.3 2 8.6 2.2 3.2 2 1 0 3 3 3 0 Domain of unknown function DUF148 TRAF_BIRC3_bd PF16673.5 AAS50912.2 - 3.3 7.5 6.9 9.8 6.1 0.0 4.1 4 1 1 5 5 5 0 TNF receptor-associated factor BIRC3 binding domain DHR10 PF18595.1 AAS50912.2 - 3.6 7.7 16.4 0.078 13.0 1.1 3.5 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 AAS50912.2 - 4.1 6.2 13.6 0.19 10.6 5.0 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein SlyX PF04102.12 AAS50912.2 - 4.8 7.9 10.7 7.6 7.2 1.8 3.6 3 1 1 4 4 3 0 SlyX WXG100 PF06013.12 AAS50912.2 - 5.2 7.4 10.2 1.7 8.9 1.9 3.8 4 2 1 5 5 3 0 Proteins of 100 residues with WXG Sec63 PF02889.16 AAS50913.2 - 1.8e-119 397.6 0.0 6e-80 268.1 0.1 2.6 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AAS50913.2 - 7e-52 175.7 0.4 6.7e-26 91.1 0.3 4.0 5 0 0 5 5 5 2 DEAD/DEAH box helicase ResIII PF04851.15 AAS50913.2 - 7.7e-32 110.6 0.1 2.5e-14 53.7 0.0 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AAS50913.2 - 1.3e-18 67.3 0.0 1.8e-08 34.7 0.0 3.8 2 1 0 2 2 2 2 Helicase conserved C-terminal domain AAA PF00004.29 AAS50913.2 - 9.3e-06 26.1 1.5 0.47 10.9 0.0 4.3 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AAS50913.2 - 0.00024 21.4 6.0 0.13 12.6 0.2 4.2 3 2 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 AAS50913.2 - 0.0024 17.6 1.5 1.7 8.3 0.0 3.7 5 0 0 5 5 5 2 IstB-like ATP binding protein PhoH PF02562.16 AAS50913.2 - 0.0032 16.9 0.0 0.64 9.4 0.0 2.5 2 0 0 2 2 2 1 PhoH-like protein T2SSE PF00437.20 AAS50913.2 - 0.023 13.8 0.0 6.3 5.8 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein TniB PF05621.11 AAS50913.2 - 0.041 13.3 0.9 30 4.0 0.1 3.6 3 0 0 3 3 3 0 Bacterial TniB protein Vps39_1 PF10366.9 AAS50913.2 - 0.11 12.7 1.1 0.48 10.7 0.0 2.6 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 ParA PF10609.9 AAS50913.2 - 0.18 11.2 0.2 4.9 6.5 0.2 2.5 2 0 0 2 2 2 0 NUBPL iron-transfer P-loop NTPase Efg1 PF10153.9 AAS50914.3 - 6.4e-32 110.3 9.3 1.2e-31 109.4 9.3 1.5 1 0 0 1 1 1 1 rRNA-processing protein Efg1 DUF2406 PF10295.9 AAS50915.1 - 7.5e-28 97.0 0.2 1.4e-27 96.1 0.2 1.5 1 0 0 1 1 1 1 Uncharacterised protein (DUF2406) Aminotran_1_2 PF00155.21 AAS50916.2 - 9.5e-56 189.5 0.0 1.2e-55 189.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II LPD7 PF18821.1 AAS50916.2 - 0.043 13.9 0.1 7 6.8 0.1 2.7 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 7 FixQ PF05545.11 AAS50916.2 - 0.086 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Peptidase_M16_C PF05193.21 AAS50917.2 - 1.2e-23 84.1 0.0 1.8e-23 83.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AAS50917.2 - 1.8e-15 57.2 0.6 4.6e-15 55.9 0.6 1.8 1 1 0 1 1 1 1 Insulinase (Peptidase family M16) DUF3110 PF11360.8 AAS50917.2 - 0.1 12.8 0.3 0.61 10.3 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3110) PPP4R2 PF09184.11 AAS50918.2 - 1.7e-40 139.4 8.1 3.1e-38 132.0 8.1 2.4 1 1 0 1 1 1 1 PPP4R2 TFIIF_alpha PF05793.12 AAS50918.2 - 0.31 9.6 17.1 0.43 9.1 17.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 AAS50918.2 - 0.54 9.5 9.3 0.73 9.1 9.3 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 AAS50918.2 - 0.6 9.5 11.0 0.74 9.2 11.0 1.1 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 AAS50918.2 - 2 7.7 19.1 3.6 6.8 19.1 1.3 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 AAS50918.2 - 2.7 8.0 10.7 3.6 7.6 10.7 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 AAS50918.2 - 4.6 5.3 13.9 6.2 4.9 13.9 1.1 1 0 0 1 1 1 0 Nop14-like family Ribosomal_S7 PF00177.21 AAS50919.2 - 6.8e-34 116.7 0.6 6.8e-34 116.7 0.6 1.6 2 0 0 2 2 2 1 Ribosomal protein S7p/S5e VanZ PF04892.12 AAS50920.2 - 4.8e-08 33.7 0.0 6.6e-08 33.3 0.0 1.2 1 0 0 1 1 1 1 VanZ like family EF-hand_4 PF12763.7 AAS50921.2 - 4.9e-28 97.1 0.0 1.8e-08 34.2 0.0 4.0 3 0 0 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_7 PF13499.6 AAS50921.2 - 6.7e-10 39.3 0.3 0.011 16.2 0.0 4.3 4 1 0 4 4 4 3 EF-hand domain pair UBA PF00627.31 AAS50921.2 - 7.4e-10 38.5 0.4 1.8e-09 37.3 0.0 2.0 2 0 0 2 2 2 1 UBA/TS-N domain EF-hand_1 PF00036.32 AAS50921.2 - 1.4e-07 30.5 0.2 0.014 14.9 0.0 4.4 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 AAS50921.2 - 3.2e-07 29.8 0.6 0.033 14.1 0.0 4.8 4 0 0 4 4 4 1 EF-hand domain UBA_4 PF14555.6 AAS50921.2 - 4.8e-05 23.1 0.2 0.0003 20.5 0.0 2.3 2 0 0 2 2 2 1 UBA-like domain Tropomyosin_1 PF12718.7 AAS50921.2 - 0.0019 18.4 19.1 0.0019 18.4 19.1 4.0 1 1 2 3 3 3 1 Tropomyosin like Spc7 PF08317.11 AAS50921.2 - 0.0049 15.8 59.3 0.064 12.1 21.5 3.3 1 1 2 3 3 3 3 Spc7 kinetochore protein EF-hand_8 PF13833.6 AAS50921.2 - 0.023 14.5 0.0 27 4.7 0.0 4.0 3 1 1 4 4 4 0 EF-hand domain pair CUE PF02845.16 AAS50921.2 - 0.025 14.3 0.7 0.22 11.3 0.0 2.9 3 0 0 3 3 3 0 CUE domain ComC PF03047.14 AAS50921.2 - 0.14 11.9 0.0 9.1 6.2 0.1 2.9 2 0 0 2 2 2 0 COMC family Filament PF00038.21 AAS50921.2 - 3.1 7.3 52.4 0.97 8.9 17.7 3.3 2 1 1 3 3 3 0 Intermediate filament protein FPP PF05911.11 AAS50921.2 - 4.3 5.4 60.1 0.032 12.5 26.3 2.4 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil DUF3584 PF12128.8 AAS50921.2 - 5.5 4.4 58.6 8.5 3.7 55.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) MAD PF05557.13 AAS50921.2 - 6.8 4.9 63.4 0.18 10.1 38.9 2.6 1 1 1 2 2 1 0 Mitotic checkpoint protein Nnf1 PF03980.14 AAS50922.1 - 6.4e-29 100.6 2.5 6.4e-29 100.6 2.5 2.1 1 1 1 2 2 2 1 Nnf1 ATG16 PF08614.11 AAS50922.1 - 0.0005 20.4 2.5 0.00062 20.1 2.5 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 AAS50922.1 - 0.0017 18.4 3.0 0.0017 18.4 3.0 2.3 2 0 0 2 2 2 1 bZIP transcription factor SOAR PF16533.5 AAS50922.1 - 0.022 14.7 2.7 0.15 12.1 0.1 2.8 2 1 1 3 3 3 0 STIM1 Orai1-activating region DUF4407 PF14362.6 AAS50922.1 - 0.06 12.7 1.7 0.22 10.9 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 AAS50922.1 - 0.097 12.8 2.3 0.2 11.7 0.2 2.1 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FlaC_arch PF05377.11 AAS50922.1 - 0.14 12.5 0.4 0.14 12.5 0.4 2.0 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) ORC3_N PF07034.11 AAS50922.1 - 0.15 11.2 0.5 0.3 10.1 0.1 1.6 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus FapA PF03961.13 AAS50922.1 - 0.42 9.2 1.7 0.6 8.6 1.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Mto2_bdg PF12808.7 AAS50922.1 - 0.48 10.7 5.8 0.93 9.8 2.1 2.7 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region KxDL PF10241.9 AAS50922.1 - 1.1 9.6 3.7 2.8 8.3 0.4 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein ADIP PF11559.8 AAS50922.1 - 6.3 6.9 9.3 1 9.4 4.4 2.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding CMD PF02627.20 AAS50923.1 - 0.00038 20.4 2.1 0.0017 18.4 0.0 2.9 4 0 0 4 4 4 1 Carboxymuconolactone decarboxylase family Myotub-related PF06602.14 AAS50924.2 - 8.2e-143 475.6 0.4 1e-142 475.3 0.4 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 AAS50924.2 - 0.0094 15.8 0.0 0.021 14.6 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AAS50924.2 - 0.02 14.4 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 AAS50924.2 - 0.021 14.8 0.0 0.04 13.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family GRAM PF02893.20 AAS50924.2 - 0.042 13.7 0.0 0.15 11.9 0.0 2.0 2 0 0 2 2 2 0 GRAM domain Yippee-Mis18 PF03226.14 AAS50925.1 - 9.8e-15 54.7 2.2 1.2e-14 54.4 2.2 1.1 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly NAD_binding_6 PF08030.12 AAS50926.1 - 5e-20 72.2 0.0 8.3e-20 71.5 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain Ferric_reduct PF01794.19 AAS50926.1 - 2e-19 70.0 13.7 2e-19 70.0 13.7 2.4 3 0 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AAS50926.1 - 9.3e-18 64.3 0.0 1.7e-17 63.4 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain SNAP PF14938.6 AAS50927.1 - 1.3e-107 359.5 14.1 1.4e-107 359.3 14.1 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 AAS50927.1 - 0.00075 20.0 8.0 1.5 9.6 0.0 5.6 4 1 0 4 4 4 1 Tetratricopeptide repeat baeRF_family10 PF18854.1 AAS50927.1 - 0.067 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 TPR_19 PF14559.6 AAS50927.1 - 3.9 8.1 18.2 1.6 9.3 0.8 4.4 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50927.1 - 8.5 6.8 20.4 6.4 7.2 0.5 6.1 5 1 1 6 6 6 0 Tetratricopeptide repeat OPT PF03169.15 AAS50928.2 - 1.9e-182 608.2 59.8 2.1e-182 608.0 59.8 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein CPSase_L_D2 PF02786.17 AAS50929.2 - 3.4e-108 360.0 0.0 4.4e-83 277.9 0.0 2.2 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 AAS50929.2 - 8.6e-37 126.2 0.0 1.6e-36 125.3 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp PF02222.22 AAS50929.2 - 3.1e-18 65.9 0.0 2.1e-08 34.0 0.0 2.3 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 AAS50929.2 - 5.7e-14 52.0 0.0 2.1e-06 27.5 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.13 AAS50929.2 - 3e-13 49.8 0.0 4.8e-06 26.3 0.0 2.3 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus MGS PF02142.22 AAS50929.2 - 0.0001 22.4 0.0 0.00036 20.7 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain ATP-grasp_5 PF13549.6 AAS50929.2 - 0.0017 17.9 0.0 0.014 14.8 0.1 2.2 2 0 0 2 2 2 1 ATP-grasp domain G-alpha PF00503.20 AAS50930.1 - 5.4e-103 344.9 0.0 8e-103 344.3 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AAS50930.1 - 7.5e-14 51.6 0.6 3e-09 36.6 0.2 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS50930.1 - 0.0004 19.8 0.8 0.041 13.2 0.1 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region Roc PF08477.13 AAS50930.1 - 0.0013 19.0 0.2 2.4 8.4 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SMP_C2CD2L PF18696.1 AAS50930.1 - 0.11 12.3 0.0 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain FtsK_SpoIIIE PF01580.18 AAS50930.1 - 0.17 11.2 0.2 0.87 8.9 0.3 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family Lipase_3 PF01764.25 AAS50931.1 - 1.5e-37 128.6 0.0 2.5e-37 127.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Glyco_transf_4 PF13439.6 AAS50931.1 - 0.067 13.2 3.2 0.11 12.5 1.5 2.0 1 1 1 2 2 2 0 Glycosyltransferase Family 4 Hydrolase_4 PF12146.8 AAS50931.1 - 0.084 12.1 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AAS50931.1 - 0.11 13.1 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Na_Ca_ex PF01699.24 AAS50932.1 - 7.6e-44 149.3 42.6 1.6e-22 80.1 17.4 2.9 3 0 0 3 3 3 2 Sodium/calcium exchanger protein PfkB PF00294.24 AAS50933.1 - 1.2e-74 251.4 0.0 1.6e-74 251.0 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 AAS50933.1 - 0.0015 18.0 0.0 0.0036 16.7 0.0 1.6 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase TRAM_LAG1_CLN8 PF03798.16 AAS50934.1 - 4.8e-29 101.5 13.9 7.2e-29 101.0 13.9 1.3 1 0 0 1 1 1 1 TLC domain Peptidase_M48_N PF16491.5 AAS50935.1 - 4.5e-41 140.7 9.3 4.5e-41 140.7 9.3 1.9 2 0 0 2 2 2 1 CAAX prenyl protease N-terminal, five membrane helices Peptidase_M48 PF01435.18 AAS50935.1 - 5e-35 121.0 0.0 1.8e-34 119.3 0.0 1.8 1 1 0 1 1 1 1 Peptidase family M48 Rpn3_C PF08375.11 AAS50936.1 - 2.6e-20 72.6 0.8 8.1e-20 71.0 0.5 2.0 2 0 0 2 2 2 1 Proteasome regulatory subunit C-terminal PCI PF01399.27 AAS50936.1 - 2.8e-20 72.8 1.6 9.7e-20 71.0 0.1 2.5 2 0 0 2 2 2 1 PCI domain TPR_2 PF07719.17 AAS50936.1 - 0.13 12.4 1.6 9.9 6.6 0.3 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Med17 PF10156.9 AAS50937.1 - 2.1e-160 534.5 8.7 2.4e-160 534.2 8.7 1.0 1 0 0 1 1 1 1 Subunit 17 of Mediator complex Ilm1 PF10311.9 AAS50938.2 - 5.8e-13 48.8 7.0 1.9e-10 40.7 7.0 2.1 1 1 0 1 1 1 1 Increased loss of mitochondrial DNA protein 1 JmjC PF02373.22 AAS50939.1 - 2.7e-40 137.3 0.6 6.7e-40 136.1 0.6 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 AAS50939.1 - 4.3e-11 42.6 0.0 1.3e-10 41.0 0.0 1.9 1 0 0 1 1 1 1 jmjN domain PHD PF00628.29 AAS50939.1 - 2.2e-08 33.9 7.5 2.2e-08 33.9 7.5 2.3 2 0 0 2 2 2 1 PHD-finger ARID PF01388.21 AAS50939.1 - 0.0018 18.9 0.0 0.0047 17.6 0.0 1.8 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD_2 PF13831.6 AAS50939.1 - 0.0052 16.3 3.3 0.0052 16.3 3.3 2.8 2 0 0 2 2 2 1 PHD-finger FYVE_2 PF02318.16 AAS50939.1 - 0.0059 16.8 2.5 0.015 15.5 2.5 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger zf-RING_2 PF13639.6 AAS50939.1 - 0.011 16.1 8.3 0.011 16.1 8.3 2.8 3 0 0 3 3 2 0 Ring finger domain zf-HC5HC2H_2 PF13832.6 AAS50939.1 - 0.02 15.0 2.2 0.051 13.7 2.2 1.6 1 0 0 1 1 1 0 PHD-zinc-finger like domain zf-RING_11 PF17123.5 AAS50939.1 - 0.38 10.5 3.8 0.73 9.6 2.1 2.4 2 0 0 2 2 2 0 RING-like zinc finger zf-HC5HC2H PF13771.6 AAS50939.1 - 0.59 10.4 8.3 0.049 13.9 3.1 1.9 2 0 0 2 2 1 0 PHD-like zinc-binding domain DUF2616 PF11077.8 AAS50939.1 - 1.2 8.8 10.3 0.046 13.4 3.7 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2616) Zf_RING PF16744.5 AAS50939.1 - 1.5 9.0 6.6 4.1 7.6 6.6 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger Prok-RING_1 PF14446.6 AAS50939.1 - 4.1 7.4 13.0 0.34 10.9 7.7 2.1 2 0 0 2 2 1 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 AAS50939.1 - 4.8 7.2 9.9 0.45 10.4 2.0 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) FYVE PF01363.21 AAS50939.1 - 5.6 7.2 16.3 0.29 11.3 7.7 2.6 2 0 0 2 2 2 0 FYVE zinc finger c-SKI_SMAD_bind PF08782.10 AAS50939.1 - 9.6 6.5 9.6 0.14 12.4 1.4 2.2 2 0 0 2 2 1 0 c-SKI Smad4 binding domain P5CR_dimer PF14748.6 AAS50940.1 - 2.1e-33 114.7 1.6 6e-33 113.2 1.6 1.8 1 0 0 1 1 1 1 Pyrroline-5-carboxylate reductase dimerisation F420_oxidored PF03807.17 AAS50940.1 - 1.3e-11 44.9 0.1 3.6e-11 43.5 0.1 1.8 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 AAS50940.1 - 0.049 13.8 0.2 0.73 10.0 0.2 2.4 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus ATP-synt_ab PF00006.25 AAS50941.2 - 3.7e-62 209.8 0.0 6.7e-62 208.9 0.0 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AAS50941.2 - 1.9e-24 86.0 3.0 6.2e-24 84.3 3.0 2.0 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATPase PF06745.13 AAS50941.2 - 0.0018 17.7 0.2 0.0033 16.8 0.2 1.5 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 AAS50941.2 - 0.0049 16.1 0.9 0.076 12.2 0.1 2.1 2 0 0 2 2 2 1 NB-ARC domain RsgA_GTPase PF03193.16 AAS50941.2 - 0.038 13.9 0.1 0.09 12.7 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 AAS50941.2 - 0.041 13.8 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain T3SS_ATPase_C PF18269.1 AAS50941.2 - 0.048 13.5 0.7 0.29 11.0 0.7 2.1 1 1 0 1 1 1 0 T3SS EscN ATPase C-terminal domain AAA PF00004.29 AAS50941.2 - 0.052 14.0 0.1 0.68 10.4 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS50941.2 - 0.088 13.2 0.6 0.3 11.4 0.2 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA_19 PF13245.6 AAS50941.2 - 0.093 13.1 1.0 0.48 10.7 0.2 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AAS50941.2 - 0.13 12.6 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 RNA helicase TsaE PF02367.17 AAS50941.2 - 0.18 11.8 0.1 0.45 10.5 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE GCV_T PF01571.21 AAS50942.1 - 0.053 12.9 0.0 8.9 5.6 0.0 2.2 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain Ribosomal_S7 PF00177.21 AAS50943.1 - 1.6e-36 125.2 2.0 2.2e-36 124.8 2.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e DUF5591 PF17884.1 AAS50943.1 - 0.05 13.5 0.0 0.084 12.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5591) Carn_acyltransf PF00755.20 AAS50944.2 - 1.8e-101 340.6 0.0 2.1e-101 340.4 0.0 1.1 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase MFS_1 PF07690.16 AAS50945.2 - 7.1e-32 110.7 52.4 2.4e-23 82.7 24.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 AAS50945.2 - 2.5e-10 39.5 27.7 1.2e-07 30.7 9.6 2.7 2 2 0 2 2 2 2 MFS/sugar transport protein MFS_1_like PF12832.7 AAS50945.2 - 4.7e-10 38.9 10.2 4.6e-06 25.7 2.5 2.3 2 0 0 2 2 2 2 MFS_1 like family Sugar_tr PF00083.24 AAS50945.2 - 6.4e-08 31.9 2.5 6.4e-08 31.9 2.5 2.7 2 1 0 3 3 3 1 Sugar (and other) transporter OATP PF03137.20 AAS50945.2 - 0.00041 18.8 0.5 0.00041 18.8 0.5 3.5 3 2 1 5 5 5 1 Organic Anion Transporter Polypeptide (OATP) family Zn_clus PF00172.18 AAS50946.2 - 7.2e-09 35.6 10.7 1.4e-08 34.7 10.7 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AAS50946.2 - 0.0022 17.1 0.5 0.0053 15.8 0.5 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain eIF2_C PF09173.11 AAS50947.2 - 1.1e-34 118.5 0.3 2.7e-34 117.3 0.3 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU PF00009.27 AAS50947.2 - 2.5e-23 82.6 0.3 2.2e-22 79.6 0.3 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 AAS50947.2 - 2.4e-11 43.9 0.3 8e-11 42.2 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS50947.2 - 0.003 17.6 0.0 0.0063 16.6 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS50947.2 - 0.0037 17.2 0.1 0.044 13.7 0.1 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1_Xtn PF16897.5 AAS50947.2 - 0.021 14.8 0.1 0.055 13.5 0.1 1.6 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain HlyD PF00529.20 AAS50947.2 - 0.075 12.9 0.2 0.56 10.1 0.0 2.5 3 0 0 3 3 3 0 HlyD membrane-fusion protein of T1SS RGS PF00615.19 AAS50948.2 - 3.4e-18 66.0 0.1 1.6e-10 41.3 0.1 2.6 2 0 0 2 2 2 2 Regulator of G protein signaling domain DEP PF00610.21 AAS50948.2 - 2.9e-12 46.5 0.0 3.9e-11 42.8 0.0 2.5 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pkinase PF00069.25 AAS50949.1 - 6.9e-75 251.8 0.0 9.8e-75 251.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS50949.1 - 2.9e-31 108.7 0.1 2.8e-30 105.5 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS50949.1 - 2.4e-08 33.3 0.0 4e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AAS50949.1 - 0.14 11.4 0.2 0.53 9.6 0.2 1.8 1 1 0 1 1 1 0 Kinase-like ORC4_C PF14629.6 AAS50950.1 - 7.2e-32 110.5 0.8 1.4e-31 109.6 0.8 1.4 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus AAA_16 PF13191.6 AAS50950.1 - 0.00071 20.0 0.1 0.0019 18.6 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 AAS50950.1 - 0.033 14.6 0.9 0.071 13.5 0.2 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF3920 PF13058.6 AAS50950.1 - 0.074 13.3 0.2 1.9 8.7 0.0 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3920) RRM_1 PF00076.22 AAS50951.2 - 5.6e-06 26.1 0.0 1.1e-05 25.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS50951.2 - 0.087 12.9 0.0 0.21 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif Herpes_UL7 PF01677.16 AAS50951.2 - 0.18 11.5 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL7 like Fmp27 PF10344.9 AAS50952.2 - 2e-189 631.7 16.5 3.4e-189 631.0 16.5 1.4 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 Fmp27_WPPW PF10359.9 AAS50952.2 - 8.1e-113 377.8 2.9 1.3e-112 377.2 2.9 1.3 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Apt1 PF10351.9 AAS50952.2 - 7.2e-83 279.0 11.2 8.9e-81 272.2 11.2 2.5 1 1 0 1 1 1 1 Golgi-body localisation protein domain Fmp27_GFWDK PF10347.9 AAS50952.2 - 9.3e-60 201.3 0.7 2.9e-59 199.6 0.0 2.3 3 0 0 3 3 3 1 RNA pol II promoter Fmp27 protein domain DUF2405 PF10293.9 AAS50952.2 - 9.9e-52 175.0 1.7 2.9e-51 173.4 1.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF2405) Fmp27_SW PF10305.9 AAS50952.2 - 2.6e-27 95.5 0.0 2.6e-26 92.3 0.0 2.9 2 0 0 2 2 2 1 RNA pol II promoter Fmp27 protein domain DUF1902 PF08972.11 AAS50952.2 - 0.31 11.1 2.4 0.54 10.3 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1902) Ras PF00071.22 AAS50954.1 - 7.6e-54 181.7 0.0 8.9e-54 181.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS50954.1 - 8e-21 74.5 0.0 1.2e-20 73.9 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS50954.1 - 5.1e-08 32.6 0.0 8e-08 31.9 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AAS50955.1 - 2.5e-55 186.5 0.0 2.9e-55 186.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS50955.1 - 3.2e-21 75.8 0.0 5.2e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS50955.1 - 8.4e-07 28.6 0.0 1.3e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AAS50955.1 - 6.4e-05 22.6 0.0 0.00017 21.2 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AAS50955.1 - 0.099 12.0 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 AAS50955.1 - 0.11 12.4 0.0 0.41 10.5 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase Ribosomal_S14 PF00253.21 AAS50956.1 - 1.8e-22 78.8 0.4 3e-22 78.1 0.4 1.4 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Pantoate_transf PF02548.15 AAS50958.1 - 1.2e-94 316.5 0.1 1.4e-94 316.3 0.1 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 AAS50958.1 - 0.0004 19.9 0.4 0.0015 18.0 0.1 1.9 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase Lactamase_B_2 PF12706.7 AAS50959.1 - 1.1e-29 103.4 0.0 1.5e-29 103.0 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AAS50959.1 - 1.4e-08 34.8 0.1 3.2e-08 33.6 0.1 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AAS50959.1 - 0.064 13.3 0.1 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily PAXNEB PF05625.11 AAS50960.2 - 6.1e-83 279.0 0.0 7.8e-83 278.6 0.0 1.0 1 0 0 1 1 1 1 PAXNEB protein Nucleoporin_N PF08801.11 AAS50961.2 - 1.4e-08 33.9 0.3 0.0025 16.7 0.0 3.0 1 1 2 3 3 3 2 Nup133 N terminal like WD40 PF00400.32 AAS50961.2 - 2.4e-05 25.0 1.1 0.017 15.9 0.0 4.0 4 0 0 4 4 4 1 WD domain, G-beta repeat Lactonase PF10282.9 AAS50961.2 - 0.00016 21.0 0.0 0.00073 18.9 0.0 1.9 2 0 0 2 2 2 1 Lactonase, 7-bladed beta-propeller ANAPC4_WD40 PF12894.7 AAS50961.2 - 0.0005 20.3 0.1 0.25 11.7 0.0 3.6 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain GTPase_binding PF09027.10 AAS50961.2 - 0.069 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 GTPase binding Romo1 PF10247.9 AAS50963.1 - 2.8e-28 98.1 7.4 3.5e-28 97.8 7.4 1.1 1 0 0 1 1 1 1 Reactive mitochondrial oxygen species modulator 1 DUF2700 PF10912.8 AAS50963.1 - 0.14 12.2 0.1 0.34 10.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) LMF1 PF06762.14 AAS50963.1 - 0.19 10.8 0.1 2.1 7.3 0.0 1.9 1 1 1 2 2 2 0 Lipase maturation factor tRNA-synt_1b PF00579.25 AAS50964.2 - 6.3e-74 248.9 0.0 7.7e-74 248.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PIG-Y PF15159.6 AAS50965.1 - 2.6e-05 25.0 11.6 3.2e-05 24.8 11.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y TssN PF17555.2 AAS50965.1 - 0.12 11.8 2.0 0.12 11.7 2.0 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssN Ion_trans PF00520.31 AAS50965.1 - 0.44 9.7 4.0 0.66 9.2 0.9 1.9 1 1 1 2 2 2 0 Ion transport protein Rad4 PF03835.15 AAS50966.1 - 7.2e-15 54.9 0.4 1.4e-14 54.0 0.4 1.5 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain Transglut_core PF01841.19 AAS50966.1 - 3.9e-11 43.4 0.3 6.8e-11 42.6 0.3 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily Sa_NUDIX PF18167.1 AAS50966.1 - 0.051 13.4 0.9 0.22 11.3 0.1 2.0 2 0 0 2 2 2 0 SMODS-associated NUDIX domain PAW PF04721.17 AAS50966.1 - 0.27 11.0 2.8 0.4 10.4 2.8 1.3 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW zf-B_box PF00643.24 AAS50966.1 - 5.1 7.3 7.6 9.6 6.5 0.3 2.9 2 1 1 3 3 3 0 B-box zinc finger Abhydrolase_1 PF00561.20 AAS50967.1 - 2.5e-19 69.9 0.0 4.9e-19 69.0 0.0 1.5 2 0 0 2 2 2 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AAS50967.1 - 6.8e-08 32.1 0.0 4.3e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Metallophos_3 PF14582.6 AAS50967.1 - 0.13 11.5 0.0 0.23 10.7 0.0 1.3 1 0 0 1 1 1 0 Metallophosphoesterase, calcineurin superfamily Dynamin_N PF00350.23 AAS50968.2 - 3.3e-18 66.3 0.2 9.4e-18 64.8 0.2 1.8 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 AAS50968.2 - 8.6e-11 41.9 0.0 4.2e-10 39.7 0.0 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS50968.2 - 2.2e-09 37.2 1.7 4.2e-08 33.0 1.7 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain cobW PF02492.19 AAS50968.2 - 0.00016 21.3 0.3 0.029 13.9 0.2 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 AAS50968.2 - 0.0039 16.6 0.1 0.023 14.1 0.0 2.3 3 0 0 3 3 3 1 Bacterial TniB protein PduV-EutP PF10662.9 AAS50968.2 - 0.0075 16.0 0.1 5.3 6.8 0.0 2.5 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 AAS50968.2 - 0.011 15.7 0.1 0.068 13.2 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AAS50968.2 - 0.023 15.2 0.0 0.21 12.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 AAS50968.2 - 0.089 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 AAS50968.2 - 0.095 12.2 0.5 9.8 5.7 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B Sec62 PF03839.16 AAS50969.2 - 1e-72 244.2 0.0 1.3e-72 243.8 0.0 1.0 1 0 0 1 1 1 1 Translocation protein Sec62 TNFR_16_TM PF18422.1 AAS50969.2 - 0.072 13.1 0.3 0.072 13.1 0.3 2.3 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain LigB PF02900.18 AAS50971.1 - 3e-26 92.1 0.0 1.9e-25 89.5 0.0 1.9 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase DUF3767 PF12597.8 AAS50972.1 - 6.1e-37 125.5 0.1 8.2e-37 125.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3767) CPP1-like PF11833.8 AAS50972.1 - 0.63 9.7 2.2 0.53 9.9 1.2 1.7 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Sel1 PF08238.12 AAS50973.1 - 7.5e-30 102.7 25.1 2.1e-10 40.9 0.0 8.0 7 2 0 7 7 7 6 Sel1 repeat TPR_17 PF13431.6 AAS50973.1 - 0.0056 17.0 1.2 4.6 7.8 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 AAS50973.1 - 0.15 12.8 5.7 3.9 8.3 0.1 5.0 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 AAS50973.1 - 1.2 9.1 8.3 25 4.9 0.4 5.6 6 0 0 6 6 6 0 Tetratricopeptide repeat CGI-121 PF08617.10 AAS50974.2 - 2.1e-39 135.2 0.0 2.4e-39 135.1 0.0 1.0 1 0 0 1 1 1 1 Kinase binding protein CGI-121 MAT1 PF06391.13 AAS50975.1 - 1.7e-60 204.4 24.3 2.2e-60 204.0 24.3 1.1 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 AAS50975.1 - 1e-28 98.9 8.9 1.8e-28 98.2 7.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS50975.1 - 0.00023 20.9 4.7 0.00054 19.7 4.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS50975.1 - 0.00029 21.1 6.1 0.00054 20.2 6.1 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AAS50975.1 - 0.0008 19.2 5.2 0.0015 18.4 5.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FliS PF02561.14 AAS50975.1 - 0.0079 16.5 1.4 0.0079 16.5 1.4 2.1 1 1 1 2 2 2 1 Flagellar protein FliS zf-C3HC4 PF00097.25 AAS50975.1 - 0.0085 15.9 5.5 0.032 14.1 5.6 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS50975.1 - 0.028 14.4 6.3 0.063 13.3 6.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Zn_ribbon_17 PF17120.5 AAS50975.1 - 0.045 13.4 1.2 0.09 12.4 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AAS50975.1 - 0.089 12.8 9.2 1.3 9.0 9.3 2.3 1 1 1 2 2 2 0 zinc-RING finger domain PolyA_pol_RNAbd PF12627.7 AAS50975.1 - 0.14 12.0 1.3 0.83 9.5 0.1 2.3 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A zf-RING_4 PF14570.6 AAS50975.1 - 1 9.2 9.6 9.8 6.1 9.6 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 AAS50975.1 - 1.1 9.2 8.7 4.8 7.1 3.0 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 3HCDH_N PF02737.18 AAS50975.1 - 1.2 9.0 4.0 2.4 8.0 4.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3797 PF12677.7 AAS50975.1 - 2.7 7.9 5.8 1.6 8.7 2.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) DHHC PF01529.20 AAS50976.2 - 4.3e-24 85.1 4.8 4.3e-24 85.1 4.8 2.2 2 0 0 2 2 2 1 DHHC palmitoyltransferase Cyt_bd_oxida_II PF02322.15 AAS50976.2 - 0.43 9.9 10.2 0.23 10.8 7.0 2.0 2 1 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II GPDPase_memb PF10110.9 AAS50976.2 - 1.5 7.5 8.6 8.3 5.1 0.1 2.2 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase A_deaminase PF00962.22 AAS50977.1 - 1.9e-127 425.2 0.0 2.7e-127 424.6 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase THP2 PF09432.10 AAS50978.2 - 3.9e-41 140.1 0.0 6.4e-41 139.4 0.0 1.3 1 0 0 1 1 1 1 Tho complex subunit THP2 ANAPC8 PF04049.13 AAS50979.2 - 1.8e-35 122.0 0.1 3.4e-35 121.1 0.1 1.4 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_1 PF00515.28 AAS50979.2 - 1.8e-26 90.8 22.3 4.2e-05 23.2 0.1 7.2 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 AAS50979.2 - 3e-22 76.9 18.2 0.00015 21.7 0.0 7.6 9 0 0 9 9 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 AAS50979.2 - 5.1e-21 73.0 20.1 0.0003 20.7 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_14 PF13428.6 AAS50979.2 - 9.2e-17 60.3 3.9 0.0047 17.6 0.0 5.7 5 1 1 6 6 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 AAS50979.2 - 2.5e-13 49.5 4.8 1.7e-07 30.8 0.0 5.4 3 3 3 6 6 6 2 TPR repeat TPR_12 PF13424.6 AAS50979.2 - 6e-09 36.1 11.4 0.031 14.5 0.1 5.4 2 1 4 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 AAS50979.2 - 9.2e-09 35.7 1.3 0.0026 18.3 0.4 4.9 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS50979.2 - 1.4e-08 35.3 7.1 5.1e-06 27.0 0.0 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 AAS50979.2 - 6.1e-08 32.5 17.6 0.0093 16.3 0.1 7.0 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 AAS50979.2 - 9.2e-08 31.6 3.2 0.092 12.8 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS50979.2 - 1.8e-07 31.2 24.6 0.014 15.6 1.8 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 ChAPs PF09295.10 AAS50979.2 - 2e-07 30.4 0.3 5.5e-07 28.9 0.1 1.8 2 0 0 2 2 2 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_9 PF13371.6 AAS50979.2 - 1.7e-05 24.8 0.9 0.46 10.7 0.6 3.6 2 1 0 3 3 3 2 Tetratricopeptide repeat BTAD PF03704.17 AAS50979.2 - 2e-05 25.1 1.5 0.00033 21.1 0.8 2.9 2 1 1 3 3 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 AAS50979.2 - 3.7e-05 23.1 3.1 0.00079 18.7 0.6 2.7 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 AAS50979.2 - 9.4e-05 22.8 13.2 5.6 7.8 0.0 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat Sel1 PF08238.12 AAS50979.2 - 0.00025 21.6 4.9 19 6.1 0.4 5.4 5 0 0 5 5 5 0 Sel1 repeat Rep_N PF08724.10 AAS50979.2 - 0.038 13.8 0.0 0.071 12.9 0.0 1.4 1 0 0 1 1 1 0 Rep protein catalytic domain like HTH_Tnp_Mu_2 PF09039.11 AAS50979.2 - 0.11 12.6 0.1 0.3 11.2 0.1 1.7 1 0 0 1 1 1 0 Mu DNA binding, I gamma subdomain PROCN PF08083.11 AAS50980.2 - 1.8e-225 748.2 11.4 2.8e-225 747.6 11.4 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 AAS50980.2 - 2.8e-123 410.0 1.5 5.2e-123 409.1 1.5 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 AAS50980.2 - 3.1e-83 277.5 1.1 3.1e-83 277.5 1.1 1.9 2 0 0 2 2 2 1 U6-snRNA interacting domain of PrP8 PRO8NT PF08082.11 AAS50980.2 - 4e-82 273.6 2.9 8.3e-82 272.6 2.9 1.6 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain U5_2-snRNA_bdg PF10597.9 AAS50980.2 - 6.4e-70 233.4 0.0 1.4e-69 232.4 0.0 1.6 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 RRM_4 PF10598.9 AAS50980.2 - 1e-46 157.2 0.1 3.4e-46 155.5 0.1 2.0 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 PROCT PF08084.11 AAS50980.2 - 7.5e-46 155.1 0.0 2.1e-45 153.6 0.0 1.9 1 0 0 1 1 1 1 PROCT (NUC072) domain TPD PF14811.6 AAS50980.2 - 0.12 12.3 0.7 0.88 9.4 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function TPD sequence-motif zf-C3H1 PF10650.9 AAS50981.1 - 0.00054 19.6 0.9 0.00094 18.9 0.9 1.4 1 0 0 1 1 1 1 Putative zinc-finger domain Chorismate_bind PF00425.18 AAS50982.1 - 7.4e-94 314.1 0.0 3.7e-93 311.8 0.0 1.9 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 AAS50982.1 - 5e-27 94.8 0.0 4e-24 85.4 0.0 4.0 4 1 0 4 4 4 1 Anthranilate synthase component I, N terminal region Sel_put PF04328.13 AAS50982.1 - 0.034 14.2 0.1 2.1 8.4 0.1 2.5 2 0 0 2 2 2 0 Selenoprotein, putative PTH2 PF01981.16 AAS50983.1 - 3.4e-45 153.1 0.8 5.6e-45 152.4 0.3 1.6 2 0 0 2 2 2 1 Peptidyl-tRNA hydrolase PTH2 PAS_4 PF08448.10 AAS50983.1 - 0.07 13.4 0.0 0.14 12.4 0.0 1.6 1 0 0 1 1 1 0 PAS fold SEP PF08059.13 AAS50984.1 - 9.9e-23 80.5 0.1 2.3e-22 79.3 0.1 1.7 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 AAS50984.1 - 1.1e-11 44.8 0.0 1.8e-11 44.1 0.0 1.4 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 AAS50984.1 - 1.6e-11 43.8 0.1 3.4e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 UBA-like domain Meth_synt_2 PF01717.18 AAS50985.2 - 1.6e-150 500.9 0.0 6.2e-146 485.8 0.0 2.9 3 0 0 3 3 3 2 Cobalamin-independent synthase, Catalytic domain Meth_synt_1 PF08267.12 AAS50985.2 - 2.7e-123 411.5 0.0 9.9e-117 389.9 0.0 2.2 2 0 0 2 2 2 2 Cobalamin-independent synthase, N-terminal domain IES5 PF17335.2 AAS50986.1 - 4.1e-40 136.6 1.2 4.6e-40 136.4 1.2 1.0 1 0 0 1 1 1 1 Ino80 complex subunit 5 RICTOR_N PF14664.6 AAS50987.2 - 1.1e-93 314.2 15.2 4.7e-93 312.1 15.2 2.1 1 1 0 1 1 1 1 Rapamycin-insensitive companion of mTOR, N-term RICTOR_M PF14666.6 AAS50987.2 - 1.9e-33 114.4 6.1 7.2e-31 106.0 0.1 5.8 5 1 1 6 6 5 1 Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V PF14668.6 AAS50987.2 - 9.5e-29 99.5 0.9 1.3e-25 89.4 0.0 3.9 4 0 0 4 4 3 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 AAS50987.2 - 4.1e-27 94.7 0.9 3.7e-26 91.6 0.9 2.9 1 0 0 1 1 1 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain HEAT_2 PF13646.6 AAS50987.2 - 0.00022 21.6 0.0 0.18 12.2 0.0 3.7 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 AAS50987.2 - 0.00027 20.9 0.2 1.6 9.2 0.0 4.6 3 0 0 3 3 3 1 HEAT repeat TMF_TATA_bd PF12325.8 AAS50987.2 - 0.0012 19.1 10.4 0.011 16.0 10.4 2.5 1 1 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 AAS50987.2 - 0.0025 18.0 4.7 0.011 15.9 4.7 2.2 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Vac14_Fab1_bd PF12755.7 AAS50987.2 - 0.013 16.1 0.1 0.46 11.1 0.1 3.2 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 AAS50987.2 - 0.035 14.1 7.9 1.1 9.3 0.9 3.6 4 0 0 4 4 2 0 non-SMC mitotic condensation complex subunit 1 ParE_toxin PF05016.15 AAS50987.2 - 0.053 14.1 0.4 0.79 10.4 0.1 3.1 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE Spc7 PF08317.11 AAS50987.2 - 0.068 12.1 7.5 0.15 10.9 7.5 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5082 PF16888.5 AAS50987.2 - 0.071 13.4 8.6 2.3 8.5 8.7 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) Arm-DNA-bind_2 PF12167.8 AAS50987.2 - 0.072 13.0 0.9 0.32 10.9 0.2 2.3 2 0 0 2 2 2 0 Arm DNA-binding domain YlqD PF11068.8 AAS50987.2 - 0.076 13.4 7.1 0.23 11.8 7.1 1.8 1 0 0 1 1 1 0 YlqD protein DUF724 PF05266.14 AAS50987.2 - 0.13 12.1 2.5 0.37 10.6 2.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ADIP PF11559.8 AAS50987.2 - 0.15 12.2 8.7 0.69 10.0 8.7 2.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Laminin_II PF06009.12 AAS50987.2 - 0.15 12.0 6.0 4.3 7.4 6.5 2.8 2 1 0 2 2 1 0 Laminin Domain II Gon7 PF08738.10 AAS50987.2 - 0.2 11.8 3.0 0.47 10.6 3.0 1.6 1 0 0 1 1 1 0 Gon7 family CENP-F_leu_zip PF10473.9 AAS50987.2 - 0.23 11.5 8.0 0.58 10.2 8.0 1.6 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Allexi_40kDa PF05549.11 AAS50987.2 - 0.34 10.4 5.2 16 4.9 5.2 2.5 1 1 0 1 1 1 0 Allexivirus 40kDa protein Repressor_Mnt PF11423.8 AAS50987.2 - 0.35 10.7 1.4 0.89 9.4 1.4 1.6 1 0 0 1 1 1 0 Regulatory protein Mnt DivIC PF04977.15 AAS50987.2 - 0.4 10.5 8.3 1.5 8.7 1.4 2.8 2 0 0 2 2 2 0 Septum formation initiator Muted PF14942.6 AAS50987.2 - 0.44 10.9 7.2 0.61 10.4 0.5 2.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Not3 PF04065.15 AAS50987.2 - 0.95 8.8 6.7 0.75 9.2 4.2 2.0 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component HR1 PF02185.16 AAS50987.2 - 0.99 9.6 14.6 1 9.5 3.5 3.0 1 1 1 2 2 2 0 Hr1 repeat Swi5 PF07061.11 AAS50987.2 - 1.3 9.2 7.9 6.1 7.0 5.7 2.9 2 1 1 3 3 2 0 Swi5 APG6_N PF17675.1 AAS50987.2 - 1.3 9.6 15.6 0.14 12.7 9.8 2.4 2 1 0 2 2 1 0 Apg6 coiled-coil region Uso1_p115_C PF04871.13 AAS50987.2 - 1.4 9.3 6.9 4.7 7.6 6.9 1.9 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region UPF0242 PF06785.11 AAS50987.2 - 1.7 8.7 11.0 0.21 11.7 5.9 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Jnk-SapK_ap_N PF09744.9 AAS50987.2 - 3.2 7.9 11.2 11 6.2 11.2 1.9 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TMF_DNA_bd PF12329.8 AAS50987.2 - 3.3 7.8 10.3 0.35 10.9 2.3 2.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 AAS50987.2 - 4.6 7.4 13.9 0.3 11.3 8.3 1.8 2 0 0 2 2 1 0 Tropomyosin like Prefoldin_2 PF01920.20 AAS50987.2 - 5.9 6.9 12.1 1.3e+02 2.6 9.2 3.3 2 1 0 2 2 2 0 Prefoldin subunit NPV_P10 PF05531.12 AAS50987.2 - 6.1 7.4 11.3 0.97 9.9 0.6 3.9 4 0 0 4 4 3 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.6 AAS50987.2 - 6.1 7.3 9.3 3.1 8.3 2.3 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) FlaC_arch PF05377.11 AAS50987.2 - 7.2 7.1 7.0 29 5.1 0.7 3.5 3 0 0 3 3 2 0 Flagella accessory protein C (FlaC) Cmc1 PF08583.10 AAS50989.1 - 1.5e-18 66.6 5.2 2e-18 66.1 5.2 1.3 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CBM_14 PF01607.24 AAS50989.1 - 0.02 15.0 0.5 0.027 14.6 0.5 1.2 1 0 0 1 1 1 0 Chitin binding Peritrophin-A domain DUF1922 PF09082.10 AAS50989.1 - 0.023 15.0 0.1 0.046 14.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1922) CX9C PF16860.5 AAS50989.1 - 0.32 11.0 4.5 3.3 7.8 0.3 2.4 1 1 1 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Proteasome PF00227.26 AAS50990.2 - 1.3e-39 135.7 0.0 1.5e-39 135.5 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Sec7 PF01369.20 AAS50991.1 - 3.9e-15 56.0 0.1 9.2e-15 54.8 0.1 1.5 1 0 0 1 1 1 1 Sec7 domain UPF0121 PF03661.13 AAS50992.1 - 8.3e-13 48.3 16.8 1.3e-12 47.6 16.8 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) TetR_C_37 PF18665.1 AAS50992.1 - 0.071 13.7 1.4 0.32 11.6 0.3 2.4 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Ras PF00071.22 AAS50993.1 - 6.5e-63 211.2 0.4 7.7e-63 210.9 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS50993.1 - 1.8e-36 124.9 0.2 3e-36 124.2 0.2 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS50993.1 - 2.2e-18 66.3 0.2 2.9e-18 65.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS50993.1 - 3.1e-06 26.7 0.3 4.8e-06 26.1 0.1 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AAS50993.1 - 0.00012 21.7 0.4 0.00043 19.9 0.2 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AAS50993.1 - 0.00015 21.8 0.1 0.00022 21.3 0.1 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS50993.1 - 0.00033 20.6 0.3 0.13 12.2 0.0 2.5 1 1 2 3 3 3 2 RsgA GTPase SRPRB PF09439.10 AAS50993.1 - 0.0016 17.9 0.1 0.0026 17.2 0.1 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA PF00004.29 AAS50993.1 - 0.0072 16.8 0.1 0.19 12.2 0.0 2.3 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) Septin PF00735.18 AAS50993.1 - 0.0098 15.2 0.2 0.11 11.8 0.0 2.1 2 0 0 2 2 2 1 Septin AAA_16 PF13191.6 AAS50993.1 - 0.041 14.3 0.0 0.055 13.8 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 AAS50993.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 AAS50993.1 - 0.066 13.5 0.0 0.14 12.4 0.0 1.8 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 AAS50993.1 - 0.084 12.9 0.0 0.15 12.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 AAS50993.1 - 0.091 13.3 0.0 0.13 12.7 0.0 1.6 1 1 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 AAS50993.1 - 0.1 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 AAS50993.1 - 0.11 12.0 0.0 0.24 10.8 0.0 1.6 2 0 0 2 2 2 0 Bacterial TniB protein NACHT PF05729.12 AAS50993.1 - 0.15 12.0 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain TMEM208_SND2 PF05620.11 AAS50994.1 - 7.9e-30 103.8 0.5 9.3e-30 103.6 0.5 1.0 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 Actin PF00022.19 AAS50995.1 - 2.6e-151 503.9 0.0 7.6e-151 502.3 0.0 1.6 1 1 0 1 1 1 1 Actin Sugar_tr PF00083.24 AAS50996.2 - 1.6e-71 241.6 35.4 2.1e-71 241.1 35.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS50996.2 - 1.9e-18 66.5 30.6 2.3e-15 56.4 18.7 2.1 1 1 0 2 2 2 2 Major Facilitator Superfamily YbhQ PF11076.8 AAS50996.2 - 3.4 7.7 7.4 3.2 7.8 0.3 2.7 2 0 0 2 2 2 0 Putative inner membrane protein YbhQ SPC22 PF04573.12 AAS50997.2 - 2.2e-55 186.7 0.3 2.6e-55 186.5 0.3 1.1 1 0 0 1 1 1 1 Signal peptidase subunit PPR PF01535.20 AAS50998.1 - 1.6e-08 34.2 3.2 0.9 9.9 0.0 7.1 8 0 0 8 8 8 3 PPR repeat PPR_long PF17177.4 AAS50998.1 - 5.6e-08 32.4 2.1 0.1 12.0 0.3 3.9 1 1 2 3 3 3 3 Pentacotripeptide-repeat region of PRORP PPR_2 PF13041.6 AAS50998.1 - 8.3e-08 32.3 0.2 7.8 6.8 0.0 6.4 5 1 1 6 6 6 2 PPR repeat family TPR_14 PF13428.6 AAS50998.1 - 4.2e-06 27.1 9.3 1.7 9.6 0.2 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat PPR_3 PF13812.6 AAS50998.1 - 0.00021 21.3 0.7 1.5 9.0 0.0 5.0 5 1 2 7 7 7 2 Pentatricopeptide repeat domain TPR_8 PF13181.6 AAS50998.1 - 0.009 16.2 0.3 3.3 8.1 0.0 3.4 2 0 0 2 2 2 1 Tetratricopeptide repeat CM_2 PF01817.21 AAS50998.1 - 0.076 13.4 0.1 1.2 9.5 0.0 2.9 2 0 0 2 2 2 0 Chorismate mutase type II Ribosomal_L12_N PF16320.5 AAS50998.1 - 0.17 11.6 0.0 0.48 10.2 0.0 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain TPR_6 PF13174.6 AAS50998.1 - 0.4 11.4 2.1 61 4.6 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat rRNA_processing PF08524.11 AAS50999.1 - 1.3e-31 109.6 37.5 1.7e-31 109.3 37.5 1.1 1 0 0 1 1 1 1 rRNA processing Cellulose_synt PF03552.14 AAS50999.1 - 6 5.2 7.1 7.2 5.0 7.1 1.1 1 0 0 1 1 1 0 Cellulose synthase GTP_EFTU PF00009.27 AAS51000.2 - 1.1e-62 211.0 0.2 2.4e-62 209.9 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AAS51000.2 - 2.8e-36 123.9 0.1 7.6e-36 122.6 0.1 1.8 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 AAS51000.2 - 5.8e-32 109.6 0.0 1.5e-31 108.3 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AAS51000.2 - 6.9e-23 80.5 0.0 1.4e-22 79.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AAS51000.2 - 2.5e-14 53.4 0.4 5.5e-14 52.3 0.4 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AAS51000.2 - 3.3e-06 27.0 0.0 8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 AAS51000.2 - 0.013 15.5 0.0 0.034 14.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase AvrPtoB_bdg PF16847.5 AAS51000.2 - 0.038 14.5 0.0 0.32 11.5 0.0 2.3 2 0 0 2 2 2 0 Avirulence AvrPtoB, BAK1-binding domain Cu-oxidase_2 PF07731.14 AAS51001.2 - 4.4e-45 152.8 7.0 1.7e-40 137.9 0.5 3.3 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AAS51001.2 - 6.4e-40 135.9 2.8 2.2e-36 124.4 0.5 3.4 4 0 0 4 4 4 2 Multicopper oxidase Cu-oxidase PF00394.22 AAS51001.2 - 1.9e-33 115.8 1.8 1.4e-28 100.1 0.1 3.3 3 0 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AAS51001.2 - 0.011 15.8 0.0 8.6 6.5 0.0 4.0 4 1 0 4 4 4 0 Cupredoxin-like domain ADH_N PF08240.12 AAS51002.1 - 2.6e-28 98.1 0.1 9.3e-28 96.3 0.0 1.8 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS51002.1 - 4.8e-24 84.8 0.1 9.4e-24 83.8 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AAS51002.1 - 5.3e-11 42.4 0.1 8.1e-11 41.8 0.1 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 AAS51002.1 - 1.2e-05 26.4 0.0 4.7e-05 24.5 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AAS51002.1 - 0.00032 20.1 0.3 0.0005 19.4 0.3 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain UDPG_MGDP_dh_N PF03721.14 AAS51002.1 - 0.0037 16.9 0.1 0.0059 16.2 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_2 PF07992.14 AAS51002.1 - 0.0058 15.9 0.2 0.013 14.7 0.1 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 AAS51002.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 AAS51002.1 - 0.17 11.6 0.1 0.29 10.8 0.1 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Pyr_redox PF00070.27 AAS51002.1 - 0.17 12.4 0.4 1.2 9.8 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AAS51002.1 - 0.22 10.2 0.2 0.35 9.5 0.2 1.3 1 0 0 1 1 1 0 HI0933-like protein Med14 PF08638.11 AAS51003.2 - 2.8e-57 193.3 0.3 2.8e-57 193.3 0.3 2.6 3 0 0 3 3 3 1 Mediator complex subunit MED14 CDT1 PF08839.11 AAS51003.2 - 0.012 16.0 2.1 0.03 14.6 2.1 1.7 1 0 0 1 1 1 0 DNA replication factor CDT1 like VASt PF16016.5 AAS51004.1 - 3.9e-38 131.3 0.8 9.7e-38 130.0 0.8 1.7 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 AAS51004.1 - 3.2e-23 81.8 0.1 2e-22 79.2 0.0 2.1 2 0 0 2 2 2 1 GRAM domain USP8_dimer PF08969.11 AAS51005.2 - 0.0002 21.5 0.1 0.00027 21.1 0.1 1.2 1 0 0 1 1 1 1 USP8 dimerisation domain Stimulus_sens_1 PF13756.6 AAS51005.2 - 0.074 13.6 0.8 2.6 8.6 0.1 2.3 2 0 0 2 2 2 0 Stimulus-sensing domain OTU PF02338.19 AAS51006.2 - 1.7e-07 31.8 0.0 2.7e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 OTU-like cysteine protease zf-C2H2_jaz PF12171.8 AAS51007.1 - 3.9e-11 42.9 2.9 6.4e-11 42.2 2.9 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AAS51007.1 - 0.00046 20.5 0.0 0.00067 19.9 0.0 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 AAS51007.1 - 0.0022 18.3 1.7 0.0036 17.7 1.7 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-U1 PF06220.12 AAS51007.1 - 0.0062 16.3 1.1 0.011 15.5 1.1 1.3 1 0 0 1 1 1 1 U1 zinc finger zf-C2H2_4 PF13894.6 AAS51007.1 - 0.011 16.5 0.6 0.026 15.3 0.6 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2HE PF16278.5 AAS51007.1 - 0.26 11.8 1.2 0.94 10.0 1.2 2.0 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger Ribosomal_L16 PF00252.18 AAS51008.1 - 6.4e-43 145.9 0.1 8e-43 145.6 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PMM PF03332.13 AAS51009.1 - 3.3e-109 363.8 0.4 3.8e-109 363.6 0.4 1.0 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 AAS51009.1 - 0.00036 20.4 0.0 0.0056 16.4 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AAS51009.1 - 0.21 11.9 0.1 0.31 11.3 0.1 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DUF1640 PF07798.11 AAS51010.2 - 1.9e-54 184.4 8.3 2.2e-54 184.1 8.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) V-ATPase_G PF03179.15 AAS51010.2 - 0.03 14.8 1.9 0.056 14.0 1.9 1.4 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Phage_Mu_Gam PF07352.12 AAS51010.2 - 0.036 14.0 6.1 0.47 10.4 0.3 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein GCN5L1 PF06320.13 AAS51010.2 - 0.047 13.9 5.4 2.9 8.1 0.1 2.8 2 1 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) FlaC_arch PF05377.11 AAS51010.2 - 0.08 13.4 5.1 3 8.3 0.4 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) Uso1_p115_C PF04871.13 AAS51010.2 - 0.17 12.3 6.3 0.1 12.9 2.5 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region XhlA PF10779.9 AAS51010.2 - 0.2 11.9 0.1 0.2 11.9 0.1 2.5 2 0 0 2 2 2 0 Haemolysin XhlA DUF1732 PF08340.11 AAS51010.2 - 0.21 11.6 7.8 0.4 10.7 7.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1732) Phage_lysis PF03245.13 AAS51010.2 - 1.7 8.8 11.1 0.43 10.7 0.8 2.3 1 1 1 2 2 2 0 Bacteriophage Rz lysis protein Baculo_PEP_C PF04513.12 AAS51010.2 - 2.1 8.4 7.1 2.5 8.1 3.1 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.10 AAS51010.2 - 7.3 6.8 11.3 4.7 7.4 3.0 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family RCC1 PF00415.18 AAS51011.2 - 1.7e-29 102.2 6.1 1.8e-08 34.8 0.0 6.6 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AAS51011.2 - 1.1e-19 69.7 12.0 9.1e-10 38.1 0.1 4.8 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat V-SNARE_C PF12352.8 AAS51012.2 - 2.6e-09 37.2 4.8 5.1e-09 36.3 4.8 1.5 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 AAS51012.2 - 4.7e-07 29.6 0.1 8e-07 28.9 0.1 1.3 1 0 0 1 1 1 1 Sec20 FlgN PF05130.12 AAS51012.2 - 0.18 12.3 2.3 0.25 11.8 0.1 2.1 2 1 0 2 2 2 0 FlgN protein RhoGAP PF00620.27 AAS51014.1 - 1.6e-10 41.0 0.0 6.3e-10 39.1 0.0 2.0 1 0 0 1 1 1 1 RhoGAP domain DEP PF00610.21 AAS51014.1 - 1.1e-08 35.0 0.0 3e-08 33.6 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) FCH PF00611.23 AAS51014.1 - 5.4e-05 23.4 1.4 0.0002 21.6 0.0 2.7 3 0 0 3 3 3 1 Fes/CIP4, and EFC/F-BAR homology domain Rdx PF10262.9 AAS51015.2 - 1.8e-26 92.1 0.0 2.4e-26 91.7 0.0 1.2 1 0 0 1 1 1 1 Rdx family KSHV_K1 PF11049.8 AAS51015.2 - 0.011 15.6 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus Lectin_leg-like PF03388.13 AAS51016.1 - 2.7e-38 131.6 0.0 4.1e-38 131.0 0.0 1.2 1 0 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 AAS51016.1 - 0.00033 20.7 0.0 0.00081 19.5 0.0 1.7 1 0 0 1 1 1 1 Bacterial lectin CDC13_N PF16853.5 AAS51016.1 - 0.047 13.2 2.6 0.078 12.5 2.6 1.2 1 0 0 1 1 1 0 Cell division control protein 13 N-terminus ATP-synt_Z PF16594.5 AAS51016.1 - 0.1 12.1 0.9 0.21 11.1 0.9 1.5 1 0 0 1 1 1 0 Putative AtpZ or ATP-synthase-associated DUF4175 PF13779.6 AAS51016.1 - 1 7.2 7.2 1.5 6.6 7.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CRC_subunit PF08624.10 AAS51017.1 - 1.6e-37 128.9 0.0 3.2e-37 128.0 0.0 1.5 1 0 0 1 1 1 1 Chromatin remodelling complex Rsc7/Swp82 subunit SidE PF12252.8 AAS51017.1 - 0.22 9.0 0.0 0.32 8.5 0.0 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein Mannosyl_trans3 PF11051.8 AAS51018.2 - 2.3e-72 243.6 0.0 3e-72 243.3 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative adh_short PF00106.25 AAS51019.2 - 1.5e-46 158.3 1.8 1.9e-46 158.0 1.8 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51019.2 - 2.8e-34 118.7 2.0 3.5e-34 118.4 2.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51019.2 - 3.9e-14 53.0 0.6 5.5e-14 52.5 0.6 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51019.2 - 4e-06 26.5 0.6 7.1e-05 22.4 0.6 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AAS51019.2 - 0.0014 18.5 1.4 0.0021 17.9 0.7 1.7 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 AAS51019.2 - 0.0073 15.4 0.2 0.0098 14.9 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family TrkA_N PF02254.18 AAS51019.2 - 0.012 15.9 0.3 0.027 14.7 0.3 1.6 1 0 0 1 1 1 0 TrkA-N domain DUF1776 PF08643.10 AAS51019.2 - 0.017 14.5 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) GDP_Man_Dehyd PF16363.5 AAS51019.2 - 0.056 12.8 0.2 0.087 12.2 0.0 1.4 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 AAS51019.2 - 0.069 12.3 0.2 0.2 10.8 0.1 1.7 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein adh_short PF00106.25 AAS51020.1 - 1.9e-46 158.0 1.2 2.6e-46 157.5 1.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51020.1 - 2.4e-36 125.5 2.4 2.8e-36 125.2 2.4 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51020.1 - 7.5e-15 55.3 0.3 1.3e-14 54.5 0.3 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51020.1 - 0.00041 19.9 0.8 0.0012 18.3 0.8 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AAS51020.1 - 0.00085 19.3 3.8 0.0011 18.9 3.3 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AAS51020.1 - 0.0034 16.6 0.1 0.0042 16.3 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF2486 PF10667.9 AAS51020.1 - 0.0053 17.0 0.6 0.0078 16.5 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2486) TrkA_N PF02254.18 AAS51020.1 - 0.015 15.6 3.0 0.018 15.3 0.5 2.3 3 0 0 3 3 3 0 TrkA-N domain NCD2 PF04905.13 AAS51020.1 - 0.018 15.0 0.0 0.033 14.2 0.0 1.3 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) DUF1776 PF08643.10 AAS51020.1 - 0.021 14.2 0.0 0.026 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) 3Beta_HSD PF01073.19 AAS51020.1 - 0.021 13.8 0.7 0.029 13.4 0.7 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 AAS51020.1 - 0.086 12.2 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase adh_short PF00106.25 AAS51021.1 - 1.4e-45 155.2 1.0 1.9e-45 154.8 1.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51021.1 - 7.4e-35 120.6 2.1 9e-35 120.3 2.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51021.1 - 1e-14 54.9 0.3 1.6e-14 54.2 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51021.1 - 6.9e-05 22.4 0.6 0.00014 21.4 0.6 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AAS51021.1 - 0.00017 21.5 3.3 0.00023 21.1 3.3 1.3 1 1 0 1 1 1 1 NAD(P)H-binding TrkA_N PF02254.18 AAS51021.1 - 0.0043 17.3 1.5 0.0097 16.2 0.5 2.1 2 0 0 2 2 2 1 TrkA-N domain Polysacc_synt_2 PF02719.15 AAS51021.1 - 0.0063 15.7 0.1 0.0097 15.1 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 AAS51021.1 - 0.018 14.1 0.5 0.024 13.7 0.5 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 AAS51021.1 - 0.047 13.1 0.0 0.075 12.4 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase LexA_DNA_bind PF01726.16 AAS51021.1 - 0.057 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 LexA DNA binding domain NCD2 PF04905.13 AAS51021.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) adh_short PF00106.25 AAS51022.1 - 4.7e-46 156.7 1.4 6.2e-46 156.3 1.4 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51022.1 - 8.4e-35 120.4 2.3 1e-34 120.2 2.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51022.1 - 7.6e-15 55.3 0.6 1.2e-14 54.6 0.6 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51022.1 - 5.9e-05 22.6 0.6 0.00013 21.5 0.6 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AAS51022.1 - 0.00039 20.4 2.0 0.00039 20.4 2.0 1.6 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AAS51022.1 - 0.0042 16.3 0.2 0.008 15.3 0.1 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein TrkA_N PF02254.18 AAS51022.1 - 0.0064 16.7 0.5 0.013 15.8 0.5 1.6 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.19 AAS51022.1 - 0.0075 15.3 0.5 0.01 14.9 0.5 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 AAS51022.1 - 0.033 13.6 0.0 0.048 13.0 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase OPT PF03169.15 AAS51023.2 - 3.7e-143 478.4 40.2 4.2e-143 478.2 40.2 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein MFS_1 PF07690.16 AAS51025.1 - 2.7e-18 66.0 27.1 6.6e-17 61.5 27.0 2.1 1 1 0 1 1 1 1 Major Facilitator Superfamily Glyco_hydro_76 PF03663.14 AAS51026.1 - 2.8e-144 481.2 4.4 3.2e-144 481.0 4.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AAS51026.1 - 1 8.4 7.5 11 5.0 0.3 3.0 2 1 1 3 3 3 0 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 AAS51027.1 - 5.1e-151 503.4 0.9 5.8e-151 503.2 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AAS51027.1 - 0.00018 20.7 2.5 0.2 10.7 0.2 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 AAS51028.1 - 3.9e-151 503.7 0.8 4.5e-151 503.5 0.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 Glyco_hydro_88 PF07470.13 AAS51028.1 - 0.00028 20.1 4.1 0.36 9.8 0.2 3.1 2 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 Peptidase_M16 PF00675.20 AAS51029.2 - 2.8e-27 95.5 0.0 4.5e-27 94.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AAS51029.2 - 4.8e-07 30.0 0.0 3.3e-06 27.2 0.0 2.3 2 1 0 2 2 2 1 Peptidase M16 inactive domain DUF3574 PF12098.8 AAS51029.2 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3574) IlvN PF07991.12 AAS51030.2 - 7.7e-44 149.2 0.0 1.1e-43 148.7 0.0 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 AAS51030.2 - 9.9e-41 139.4 0.0 1.8e-40 138.5 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.15 AAS51030.2 - 0.022 14.9 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase AhpC-TSA PF00578.21 AAS51031.1 - 1.7e-29 102.3 0.0 2.3e-29 101.8 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AAS51031.1 - 5.3e-07 29.4 0.0 7e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 AAS51031.1 - 7.2e-05 22.6 0.0 0.00011 22.0 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin TAL_FSA PF00923.19 AAS51032.2 - 1e-96 323.7 0.0 1.2e-96 323.5 0.0 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase Zn_clus PF00172.18 AAS51033.1 - 2.2e-08 34.1 10.1 2.2e-08 34.1 10.1 1.5 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2439 PF10382.9 AAS51034.2 - 3.5e-21 75.3 0.2 4.5e-21 75.0 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) LRR_4 PF12799.7 AAS51036.1 - 4.4e-05 23.8 3.8 0.014 15.8 0.5 4.5 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AAS51036.1 - 0.85 10.4 6.8 52 5.0 0.1 5.7 5 1 0 5 5 5 0 Leucine Rich Repeat Pkinase PF00069.25 AAS51037.1 - 1.7e-67 227.6 0.0 2.2e-67 227.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51037.1 - 1.9e-32 112.6 0.0 2.8e-32 112.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AAS51037.1 - 3.2e-05 23.4 0.0 5e-05 22.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AAS51037.1 - 4.9e-05 22.8 0.0 8.3e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AAS51037.1 - 0.00049 19.1 0.1 0.00073 18.6 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 AAS51037.1 - 0.0052 16.4 0.0 0.017 14.7 0.1 1.9 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AAS51037.1 - 0.014 15.3 0.0 0.024 14.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF3388 PF11868.8 AAS51037.1 - 0.13 11.6 0.1 0.22 10.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3388) CN_hydrolase PF00795.22 AAS51038.1 - 3.5e-59 200.3 0.0 3.9e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase ORMDL PF04061.14 AAS51039.1 - 9.1e-57 190.7 6.5 1.1e-56 190.4 6.5 1.1 1 0 0 1 1 1 1 ORMDL family ACBP PF00887.19 AAS51040.1 - 3.6e-28 97.6 1.2 3.9e-28 97.5 1.2 1.0 1 0 0 1 1 1 1 Acyl CoA binding protein FERM_M PF00373.18 AAS51040.1 - 0.0086 16.5 0.1 0.54 10.7 0.1 2.0 1 1 0 1 1 1 1 FERM central domain HEAT PF02985.22 AAS51041.2 - 2e-17 61.8 16.8 0.00033 20.7 0.1 11.1 11 0 0 11 11 11 3 HEAT repeat HEAT_EZ PF13513.6 AAS51041.2 - 5.3e-11 42.8 10.7 1.1e-07 32.2 0.0 7.8 10 1 2 12 12 11 2 HEAT-like repeat IBN_N PF03810.19 AAS51041.2 - 8.2e-11 41.7 0.7 2.1e-09 37.1 0.3 3.6 4 0 0 4 4 4 1 Importin-beta N-terminal domain Cnd1 PF12717.7 AAS51041.2 - 2.1e-07 31.1 7.0 0.11 12.5 0.0 5.7 1 1 2 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AAS51041.2 - 7e-07 29.1 7.4 0.0067 16.4 0.1 6.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 AAS51041.2 - 8.5e-07 29.3 6.6 0.17 12.3 0.0 6.8 3 2 6 9 9 9 3 HEAT repeats CLASP_N PF12348.8 AAS51041.2 - 1.4e-05 24.8 0.8 0.65 9.5 0.0 4.7 5 0 0 5 5 5 2 CLASP N terminal SIL1 PF16782.5 AAS51041.2 - 0.00018 20.8 0.3 0.00046 19.5 0.3 1.6 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 CAS_CSE1 PF03378.15 AAS51041.2 - 0.00034 19.2 3.4 3 6.2 0.8 5.0 2 1 1 3 3 3 2 CAS/CSE protein, C-terminus DUF3385 PF11865.8 AAS51041.2 - 0.00034 20.5 0.2 1.3 8.9 0.0 4.7 2 2 0 2 2 2 1 Domain of unknown function (DUF3385) Sec7_N PF12783.7 AAS51041.2 - 0.0008 19.3 1.3 0.016 15.1 0.1 3.3 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Caskin-tail PF16632.5 AAS51041.2 - 0.0055 17.1 0.0 2.1 8.8 0.0 3.4 2 0 0 2 2 2 1 C-terminal region of Caskin RTP1_C1 PF10363.9 AAS51041.2 - 0.0071 16.5 4.7 17 5.6 0.3 5.6 4 1 1 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 RICTOR_V PF14668.6 AAS51041.2 - 0.043 14.0 0.2 9 6.6 0.0 3.6 3 0 0 3 3 2 0 Rapamycin-insensitive companion of mTOR, domain 5 RIX1 PF08167.12 AAS51041.2 - 0.076 12.7 0.1 4.5 7.0 0.0 4.0 4 1 1 5 5 5 0 rRNA processing/ribosome biogenesis PAP2 PF01569.21 AAS51042.1 - 3.9e-18 65.5 1.5 3.9e-18 65.5 1.5 1.5 2 0 0 2 2 2 1 PAP2 superfamily DUF5317 PF17248.2 AAS51042.1 - 0.1 12.6 0.6 0.1 12.6 0.6 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5317) 6PF2K PF01591.18 AAS51043.1 - 5.2e-56 189.4 0.0 7.9e-56 188.8 0.0 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AAS51043.1 - 2.4e-16 60.0 0.0 7.7e-16 58.4 0.0 1.8 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AAS51043.1 - 0.0012 19.0 0.1 0.0012 19.0 0.1 2.6 3 1 0 3 3 3 1 AAA domain Ribosomal_L26 PF16906.5 AAS51044.1 - 1.2e-38 131.4 3.4 1.6e-38 131.0 3.4 1.2 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AAS51044.1 - 7.5e-05 22.5 1.7 7.5e-05 22.5 1.7 1.8 2 0 0 2 2 2 1 KOW motif TIM21 PF08294.11 AAS51045.1 - 3.6e-57 192.3 0.0 4.4e-57 192.0 0.0 1.1 1 0 0 1 1 1 1 TIM21 Glyco_hydro_72 PF03198.14 AAS51046.1 - 7.2e-138 459.1 0.2 9.4e-138 458.7 0.2 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AAS51046.1 - 8.6e-14 52.0 0.5 2.2e-13 50.7 0.5 1.7 1 0 0 1 1 1 1 X8 domain Glucan_synthase PF02364.15 AAS51047.2 - 0 1343.3 0.0 0 1342.8 0.0 1.2 1 0 0 1 1 1 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AAS51047.2 - 1.3e-41 141.9 0.1 3.4e-41 140.6 0.1 1.8 1 0 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 GP24_25 PF17388.2 AAS51047.2 - 0.2 11.6 0.1 0.42 10.6 0.1 1.5 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 Abhydrolase_1 PF00561.20 AAS51048.2 - 2.6e-25 89.6 0.0 1.2e-24 87.4 0.0 1.8 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AAS51048.2 - 6.2e-16 59.7 8.9 9.2e-16 59.1 8.9 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS51048.2 - 1.4e-12 47.5 0.0 1.7e-12 47.1 0.0 1.3 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AAS51048.2 - 7.4e-09 36.1 0.0 1.1e-08 35.5 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 AAS51048.2 - 0.0012 18.6 0.0 0.42 10.3 0.0 2.1 2 0 0 2 2 2 2 PGAP1-like protein Esterase PF00756.20 AAS51048.2 - 0.0075 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_3 PF07859.13 AAS51048.2 - 0.0075 16.1 0.0 0.0093 15.8 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 AAS51048.2 - 0.15 11.0 0.0 0.23 10.4 0.0 1.2 1 0 0 1 1 1 0 Chlorophyllase enzyme Ribosomal_L10 PF00466.20 AAS51050.2 - 6.2e-26 90.4 0.3 1.1e-25 89.7 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 RL10P_insert PF17777.1 AAS51050.2 - 5.4e-21 74.4 0.0 8.7e-21 73.7 0.0 1.3 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 AAS51050.2 - 3.1e-16 59.7 4.9 3.4e-16 59.6 1.5 2.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein Alba PF01918.21 AAS51051.1 - 0.0002 21.1 0.1 0.00029 20.6 0.1 1.2 1 0 0 1 1 1 1 Alba ATP-synt PF00231.19 AAS51052.2 - 3.1e-75 253.5 4.5 3.5e-75 253.3 4.5 1.0 1 0 0 1 1 1 1 ATP synthase Fig1 PF12351.8 AAS51053.2 - 2.7e-56 190.5 0.6 2.7e-56 190.5 0.6 1.4 2 0 0 2 2 2 1 Ca2+ regulator and membrane fusion protein Fig1 SUR7 PF06687.12 AAS51053.2 - 0.029 14.0 15.1 0.2 11.3 15.1 2.0 1 1 0 1 1 1 0 SUR7/PalI family Renin_r PF07850.14 AAS51053.2 - 2.3 8.9 4.2 0.68 10.6 0.3 2.1 3 0 0 3 3 3 0 Renin receptor-like protein AMP-binding PF00501.28 AAS51054.2 - 5.1e-61 206.5 0.0 6.5e-61 206.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AAS51054.2 - 0.0023 18.9 0.0 0.0047 17.9 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Acyltransferase PF01553.21 AAS51055.1 - 5.7e-30 103.7 0.0 8.8e-30 103.1 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 AAS51055.1 - 2.3e-14 53.2 0.1 5.1e-14 52.1 0.1 1.6 1 0 0 1 1 1 1 Acyltransferase C-terminus MFS_1 PF07690.16 AAS51056.1 - 1.5e-37 129.4 26.5 1.5e-37 129.4 26.5 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS51056.1 - 1.3e-09 37.5 1.0 1.3e-09 37.5 1.0 2.4 2 0 0 2 2 2 1 Sugar (and other) transporter Ctr PF04145.15 AAS51056.1 - 0.027 15.1 0.2 0.12 13.0 0.0 2.2 2 0 0 2 2 2 0 Ctr copper transporter family YCII PF03795.14 AAS51059.1 - 2e-09 37.7 0.0 2.4e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 YCII-related domain Profilin PF00235.19 AAS51060.1 - 2.9e-45 153.6 0.2 3.2e-45 153.5 0.2 1.0 1 0 0 1 1 1 1 Profilin Leo1 PF04004.13 AAS51061.2 - 3e-46 157.3 0.1 3e-46 157.3 0.1 1.8 2 0 0 2 2 2 1 Leo1-like protein SIR2_2 PF13289.6 AAS51061.2 - 0.073 13.2 0.2 0.24 11.5 0.0 1.9 2 0 0 2 2 2 0 SIR2-like domain Glyco_hydro_18 PF00704.28 AAS51062.1 - 1.1e-71 242.1 0.9 1.4e-71 241.8 0.9 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 GPP34 PF05719.11 AAS51063.1 - 2.5e-63 213.8 0.1 3.3e-63 213.4 0.1 1.1 1 0 0 1 1 1 1 Golgi phosphoprotein 3 (GPP34) UCH PF00443.29 AAS51064.2 - 3.4e-51 174.2 0.0 3e-50 171.1 0.0 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase RPT PF13446.6 AAS51064.2 - 4.1e-39 132.3 10.1 2.8e-15 56.0 0.1 4.9 4 0 0 4 4 4 4 A repeated domain in UCH-protein UCH_1 PF13423.6 AAS51064.2 - 0.00034 20.3 0.1 0.012 15.2 0.0 2.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TPR_11 PF13414.6 AAS51064.2 - 0.49 10.1 2.1 1.8 8.3 2.1 2.1 1 0 0 1 1 1 0 TPR repeat bZIP_Maf PF03131.17 AAS51064.2 - 0.65 10.6 3.8 1.8 9.2 3.8 1.7 1 0 0 1 1 1 0 bZIP Maf transcription factor EF-hand_1 PF00036.32 AAS51065.1 - 1.4e-29 99.4 2.6 9.3e-08 31.1 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AAS51065.1 - 2e-26 92.2 2.6 8.7e-18 64.6 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS51065.1 - 7.9e-26 87.7 3.7 6.4e-07 28.8 0.1 4.9 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 AAS51065.1 - 2.4e-19 67.9 2.7 2.8e-05 23.4 0.2 4.6 5 0 0 5 5 5 3 EF hand EF-hand_8 PF13833.6 AAS51065.1 - 4.8e-18 64.8 4.5 9e-08 31.8 0.1 4.1 2 1 2 4 4 4 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 AAS51065.1 - 8.2e-07 29.3 0.8 0.066 13.5 0.1 3.0 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 AAS51065.1 - 4.6e-05 23.3 3.4 0.66 10.0 0.1 3.7 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AAS51065.1 - 0.0006 20.1 0.2 0.079 13.3 0.0 2.8 1 1 1 2 2 2 1 EF-hand domain S10_plectin PF03501.15 AAS51065.1 - 0.032 14.3 0.0 0.072 13.2 0.0 1.7 1 0 0 1 1 1 0 Plectin/S10 domain DUF1707 PF08044.11 AAS51065.1 - 0.21 11.7 0.0 20 5.4 0.0 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF1707) COQ7 PF03232.13 AAS51066.1 - 1.9e-74 249.1 0.0 2.3e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquinone biosynthesis protein COQ7 DUF4611 PF15387.6 AAS51066.1 - 0.18 12.0 0.0 0.35 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YTH PF04146.15 AAS51067.1 - 1.2e-30 106.6 0.3 3.8e-30 105.0 0.3 1.8 1 1 0 1 1 1 1 YT521-B-like domain Sel1 PF08238.12 AAS51068.1 - 4.5e-16 58.9 19.6 8.5e-05 23.1 0.2 8.2 8 0 0 8 8 8 3 Sel1 repeat TPR_7 PF13176.6 AAS51068.1 - 0.082 13.0 6.3 8 6.8 0.0 4.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Thyroglob_assoc PF16597.5 AAS51068.1 - 0.15 12.4 0.1 0.3 11.4 0.1 1.4 1 0 0 1 1 1 0 Thyroglobulin_1 repeat associated disordered domain Dynactin_p62 PF05502.13 AAS51069.1 - 7.8e-16 57.9 24.4 6.6e-09 35.1 18.9 2.1 1 1 0 2 2 2 2 Dynactin p62 family zf-Mss51 PF13824.6 AAS51069.1 - 1.5 9.0 10.3 0.77 9.9 4.7 2.8 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-TFIIB PF13453.6 AAS51069.1 - 1.8 7.9 17.9 0.2 11.0 1.2 3.8 4 0 0 4 4 4 0 Transcription factor zinc-finger CENP-X PF09415.10 AAS51070.1 - 6.7e-25 87.2 0.4 7.9e-25 87.0 0.4 1.1 1 0 0 1 1 1 1 CENP-S associating Centromere protein X CBFD_NFYB_HMF PF00808.23 AAS51070.1 - 0.056 13.7 0.1 0.079 13.3 0.1 1.3 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAFII28 PF04719.14 AAS51070.1 - 0.057 13.5 0.0 0.06 13.4 0.0 1.1 1 0 0 1 1 1 0 hTAFII28-like protein conserved region ENTH PF01417.20 AAS51071.1 - 3.7e-40 136.8 0.0 6.8e-40 136.0 0.0 1.5 1 0 0 1 1 1 1 ENTH domain DUF5475 PF17569.2 AAS51071.1 - 0.28 11.5 1.0 1.9 8.9 0.0 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5475) DNA_ligase_A_M PF01068.21 AAS51073.1 - 1e-62 211.4 0.1 1.5e-62 210.9 0.1 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 AAS51073.1 - 4.6e-46 157.3 0.0 9.7e-46 156.2 0.0 1.6 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 AAS51073.1 - 1.7e-23 83.1 0.0 4.3e-23 81.8 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 AAS51073.1 - 0.00012 22.4 0.0 0.00034 21.0 0.0 1.7 2 0 0 2 2 2 1 RNA ligase DUF1685 PF07939.11 AAS51073.1 - 0.13 12.1 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1685) Heme_oxygenase PF01126.20 AAS51074.1 - 1.2e-16 61.1 1.4 3.3e-16 59.7 0.9 2.0 2 1 0 2 2 2 1 Heme oxygenase DUF1713 PF08213.11 AAS51075.1 - 6.4e-14 51.6 17.5 9e-14 51.1 17.5 1.2 1 0 0 1 1 1 1 Mitochondrial domain of unknown function (DUF1713) zf-Mss51 PF13824.6 AAS51076.1 - 9.3e-18 64.1 0.7 9.3e-18 64.1 0.7 1.7 2 0 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 NOT2_3_5 PF04153.18 AAS51077.1 - 4.4e-30 104.4 0.1 5.9e-30 104.0 0.1 1.2 1 0 0 1 1 1 1 NOT2 / NOT3 / NOT5 family AAA_18 PF13238.6 AAS51078.1 - 1.5e-30 106.4 0.1 4.9e-30 104.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_17 PF13207.6 AAS51078.1 - 4.5e-09 36.9 0.0 1.1e-08 35.6 0.0 1.7 2 1 0 2 2 1 1 AAA domain AAA_28 PF13521.6 AAS51078.1 - 2.7e-05 24.5 0.0 0.00018 21.8 0.0 2.2 1 1 2 3 3 3 1 AAA domain AAA_16 PF13191.6 AAS51078.1 - 5.2e-05 23.7 0.0 0.00012 22.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 AAS51078.1 - 0.00025 21.2 0.0 0.42 10.8 0.0 2.6 1 1 1 3 3 3 2 AAA domain RNA_helicase PF00910.22 AAS51078.1 - 0.0013 19.1 0.0 0.0033 17.8 0.0 1.6 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 AAS51078.1 - 0.0017 18.7 0.0 0.0033 17.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AAS51078.1 - 0.0018 18.7 0.0 0.0067 16.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ADK PF00406.22 AAS51078.1 - 0.0018 18.4 0.0 0.38 10.9 0.0 2.2 2 0 0 2 2 2 1 Adenylate kinase dNK PF01712.19 AAS51078.1 - 0.0048 16.8 0.0 0.68 9.8 0.0 2.2 2 0 0 2 2 2 1 Deoxynucleoside kinase Zeta_toxin PF06414.12 AAS51078.1 - 0.0052 16.1 0.0 0.013 14.8 0.0 1.6 2 0 0 2 2 2 1 Zeta toxin Thymidylate_kin PF02223.17 AAS51078.1 - 0.011 15.4 0.0 3.4 7.3 0.0 2.4 2 1 0 2 2 2 0 Thymidylate kinase Rad17 PF03215.15 AAS51078.1 - 0.012 15.6 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Viral_helicase1 PF01443.18 AAS51078.1 - 0.014 15.1 0.0 0.022 14.5 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Imm8 PF15586.6 AAS51078.1 - 0.018 15.0 0.1 0.03 14.3 0.1 1.5 1 0 0 1 1 1 0 Immunity protein 8 T2SSE PF00437.20 AAS51078.1 - 0.034 13.2 0.0 0.096 11.7 0.0 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein KTI12 PF08433.10 AAS51078.1 - 0.044 13.2 0.0 0.18 11.2 0.0 1.8 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Mg_chelatase PF01078.21 AAS51078.1 - 0.046 13.1 0.0 0.07 12.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI T4_Rnl2_C PF18043.1 AAS51078.1 - 0.065 13.4 0.6 0.13 12.5 0.2 1.6 2 0 0 2 2 2 0 T4 RNA ligase 2 C-terminal AAA_14 PF13173.6 AAS51078.1 - 0.069 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AAS51078.1 - 0.096 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 AAS51078.1 - 0.13 12.3 0.0 0.36 10.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) zf-RanBP PF00641.18 AAS51079.1 - 1.8e-19 68.7 12.3 7.1e-10 38.0 1.9 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others RRM_1 PF00076.22 AAS51079.1 - 1.1e-08 34.8 0.0 0.00063 19.5 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4407 PF14362.6 AAS51079.1 - 0.14 11.5 4.9 0.21 10.9 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DZR PF12773.7 AAS51079.1 - 0.21 11.6 8.1 3.9 7.6 1.2 2.6 2 0 0 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AAS51079.1 - 0.79 9.2 3.8 0.76 9.3 0.6 2.5 2 0 0 2 2 2 0 zinc-ribbon domain ADH_N PF08240.12 AAS51080.1 - 5.9e-24 84.1 3.4 5.9e-24 84.1 3.4 2.0 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS51080.1 - 4.5e-23 81.6 0.3 4.5e-23 81.6 0.3 1.7 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Sacchrp_dh_NADP PF03435.18 AAS51080.1 - 9.1e-05 22.7 0.1 0.00021 21.6 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AlaDh_PNT_C PF01262.21 AAS51080.1 - 0.005 16.2 1.0 0.0089 15.3 1.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 AAS51080.1 - 0.0064 16.8 0.0 0.013 15.8 0.0 1.5 1 0 0 1 1 1 1 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 AAS51080.1 - 0.035 13.7 0.1 0.07 12.7 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 AAS51080.1 - 0.055 12.8 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain HycI PF01750.18 AAS51080.1 - 0.084 12.7 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase maturation protease ADH_zinc_N_2 PF13602.6 AAS51080.1 - 0.12 13.4 0.0 0.25 12.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-binding dehydrogenase Pep_deformylase PF01327.21 AAS51080.1 - 0.15 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Polypeptide deformylase COQ9 PF08511.11 AAS51081.1 - 1.6e-22 79.0 0.3 8.9e-22 76.7 0.1 2.3 3 0 0 3 3 3 1 COQ9 Prefoldin_2 PF01920.20 AAS51082.1 - 1.1e-23 83.2 11.0 1.2e-23 83.1 11.0 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1192 PF06698.11 AAS51082.1 - 0.011 15.8 2.4 0.011 15.7 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) SKA2 PF16740.5 AAS51082.1 - 0.022 14.5 4.9 0.39 10.5 2.0 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DcrB PF08786.11 AAS51082.1 - 0.035 14.2 2.0 0.044 13.9 2.0 1.2 1 0 0 1 1 1 0 DcrB Rh5 PF18515.1 AAS51082.1 - 0.049 12.9 0.0 0.052 12.8 0.0 1.1 1 0 0 1 1 1 0 Rh5 coiled-coil domain Prefoldin PF02996.17 AAS51082.1 - 0.073 13.0 7.8 0.46 10.4 0.5 2.1 1 1 1 2 2 2 0 Prefoldin subunit DUF4164 PF13747.6 AAS51082.1 - 0.14 12.4 5.6 0.39 11.0 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF1843 PF08898.10 AAS51082.1 - 0.19 12.2 5.4 2.5 8.7 1.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF1843) UPF0242 PF06785.11 AAS51082.1 - 0.21 11.6 8.5 0.24 11.5 8.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ATG16 PF08614.11 AAS51082.1 - 0.29 11.4 10.1 3.2 7.9 3.9 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 AAS51082.1 - 0.47 10.5 11.0 1.2 9.1 3.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 AAS51082.1 - 0.49 10.7 13.3 1 9.7 2.7 2.4 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF4200 PF13863.6 AAS51082.1 - 0.7 10.3 12.2 0.71 10.3 2.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Spc24 PF08286.11 AAS51082.1 - 1 9.6 7.2 1.4 9.1 1.2 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 HalX PF08663.10 AAS51082.1 - 1.3 9.4 6.9 0.34 11.2 2.0 2.1 2 0 0 2 2 2 0 HalX domain OmpH PF03938.14 AAS51082.1 - 1.5 9.2 10.7 2.9 8.2 10.7 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Bcr-Abl_Oligo PF09036.10 AAS51082.1 - 1.6 8.8 4.5 3.5 7.7 0.4 2.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DMPK_coil PF08826.10 AAS51082.1 - 2.7 8.2 12.8 1.4 9.1 2.8 2.3 2 0 0 2 2 2 0 DMPK coiled coil domain like DUF5595 PF18077.1 AAS51082.1 - 3.1 7.9 8.2 0.69 10.0 1.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5595) ZapB PF06005.12 AAS51082.1 - 5.6 7.5 16.3 90 3.6 16.3 2.1 1 1 0 1 1 1 0 Cell division protein ZapB POC1 PF10450.9 AAS51083.2 - 1.5e-37 129.1 0.0 1.8e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 POC1 chaperone Nop PF01798.18 AAS51084.1 - 6.4e-85 284.3 0.1 6.4e-85 284.3 0.1 2.4 2 1 0 2 2 2 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AAS51084.1 - 4e-20 72.0 0.1 4e-20 72.0 0.1 3.3 2 1 0 2 2 2 1 NOP5NT (NUC127) domain XRN_M PF17846.1 AAS51084.1 - 3.2 6.6 23.0 5.1 5.9 23.0 1.4 1 0 0 1 1 1 0 Xrn1 helical domain CDC45 PF02724.14 AAS51084.1 - 3.8 5.7 38.3 5.2 5.3 38.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Ion_trans PF00520.31 AAS51085.1 - 4.4e-100 333.9 102.0 1.9e-37 128.8 9.1 5.0 4 1 0 4 4 4 4 Ion transport protein EF-hand_1 PF00036.32 AAS51085.1 - 0.034 13.7 0.1 0.13 11.9 0.1 2.0 1 0 0 1 1 1 0 EF hand Gpi1 PF05024.15 AAS51086.1 - 4.7e-59 199.6 10.7 8.3e-59 198.8 10.7 1.4 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) Pox_I6 PF04595.13 AAS51086.1 - 0.046 12.7 0.1 0.085 11.8 0.1 1.4 1 0 0 1 1 1 0 Poxvirus I6-like family MRP-S33 PF08293.11 AAS51087.1 - 3.5e-32 110.5 0.1 4.7e-32 110.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Ribosomal_S2 PF00318.20 AAS51088.1 - 1.3e-24 86.7 0.2 1.9e-13 50.2 0.0 2.2 1 1 1 2 2 2 2 Ribosomal protein S2 40S_SA_C PF16122.5 AAS51088.1 - 3.8e-05 24.9 10.2 8.1e-05 23.9 10.2 1.5 1 0 0 1 1 1 1 40S ribosomal protein SA C-terminus Ferric_reduct PF01794.19 AAS51089.1 - 3.8e-21 75.5 10.8 3.8e-21 75.5 10.8 2.3 2 0 0 2 2 2 1 Ferric reductase like transmembrane component NAD_binding_6 PF08030.12 AAS51089.1 - 0.0051 17.0 0.0 0.022 14.9 0.0 2.0 2 1 0 2 2 2 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 AAS51089.1 - 0.016 15.3 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 FAD-binding domain AATase PF07247.12 AAS51090.1 - 5.2e-49 167.1 0.0 7e-48 163.4 0.0 1.9 1 1 0 1 1 1 1 Alcohol acetyltransferase Condensation PF00668.20 AAS51090.1 - 9.8e-05 21.2 0.0 0.092 11.4 0.0 2.1 2 0 0 2 2 2 2 Condensation domain zf-ZPR1 PF03367.13 AAS51091.1 - 8.1e-116 383.3 1.0 4.4e-58 195.6 0.3 2.4 2 0 0 2 2 2 2 ZPR1 zinc-finger domain APH PF01636.23 AAS51091.1 - 0.034 14.1 0.3 0.072 13.0 0.2 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family zinc_ribbon_2 PF13240.6 AAS51091.1 - 1.7 8.5 13.8 5.9 6.7 0.6 4.2 4 0 0 4 4 4 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 AAS51091.1 - 1.8 8.6 6.3 0.92 9.5 0.9 2.5 2 1 0 2 2 2 0 zinc-ribbons zinc_ribbon_4 PF13717.6 AAS51091.1 - 2.2 8.3 6.7 20 5.2 0.1 3.8 3 1 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AAS51091.1 - 4.1 7.4 6.9 23 5.0 0.0 3.4 2 1 2 4 4 4 0 Putative transposase DNA-binding domain Cytochrom_C_2 PF01322.20 AAS51091.1 - 7.9 7.4 8.2 9.5 7.1 0.1 3.3 4 0 0 4 4 4 0 Cytochrome C' MMR_HSR1_C PF08438.10 AAS51092.2 - 1.5e-32 112.5 0.0 2.3e-32 111.9 0.0 1.3 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AAS51092.2 - 7.1e-20 71.2 0.0 1.5e-19 70.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS51092.2 - 3.6e-07 29.8 0.0 1.3e-05 24.8 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.27 AAS51092.2 - 0.0031 17.1 0.1 2.3 7.7 0.0 2.9 3 0 0 3 3 3 2 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 AAS51092.2 - 0.027 14.5 0.1 0.065 13.3 0.1 1.7 2 0 0 2 2 2 0 Dynamin family FtsK_SpoIIIE PF01580.18 AAS51092.2 - 0.06 12.7 0.2 1 8.7 0.1 2.2 2 0 0 2 2 2 0 FtsK/SpoIIIE family ATP_bind_1 PF03029.17 AAS51092.2 - 0.1 12.4 0.1 19 4.9 0.1 2.8 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 AAS51092.2 - 0.2 11.5 0.0 9 6.2 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase KTI12 PF08433.10 AAS51092.2 - 0.24 10.8 0.0 0.38 10.2 0.0 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AA_permease PF00324.21 AAS51093.1 - 7.4e-121 404.1 35.5 8.8e-121 403.8 35.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS51093.1 - 3.8e-30 105.1 38.2 5.6e-30 104.5 38.2 1.3 1 0 0 1 1 1 1 Amino acid permease Phage_holin_1 PF04531.13 AAS51093.1 - 0.85 10.2 4.4 1 9.9 1.6 2.6 2 0 0 2 2 2 0 Bacteriophage holin TPP_enzyme_N PF02776.18 AAS51094.1 - 1.2e-31 109.7 0.0 2e-31 108.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS51094.1 - 4.9e-26 91.1 0.0 1.7e-25 89.4 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AAS51094.1 - 1.6e-14 54.0 0.0 2.7e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain CO_dh PF02552.16 AAS51094.1 - 0.099 12.4 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit RRM_1 PF00076.22 AAS51095.1 - 0.013 15.3 0.0 0.033 14.0 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CLASP_N PF12348.8 AAS51096.1 - 1.9e-08 34.2 0.1 5.1e-08 32.8 0.1 1.7 1 0 0 1 1 1 1 CLASP N terminal APG6_N PF17675.1 AAS51096.1 - 0.00048 20.7 2.8 0.00048 20.7 2.8 2.7 3 0 0 3 3 3 1 Apg6 coiled-coil region HEAT PF02985.22 AAS51096.1 - 0.0019 18.3 0.0 0.32 11.4 0.0 3.8 4 0 0 4 4 2 1 HEAT repeat DUF3450 PF11932.8 AAS51096.1 - 0.0041 16.5 5.2 0.0041 16.5 5.2 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 AAS51096.1 - 0.0064 16.6 5.9 0.0064 16.6 5.9 3.6 4 0 0 4 4 4 1 TPR/MLP1/MLP2-like protein DUF641 PF04859.12 AAS51096.1 - 0.011 16.1 2.3 0.011 16.1 2.3 2.9 3 0 0 3 3 2 0 Plant protein of unknown function (DUF641) PIN_4 PF13638.6 AAS51096.1 - 0.013 15.8 0.8 0.056 13.7 0.2 2.4 2 0 0 2 2 2 0 PIN domain Ead_Ea22 PF13935.6 AAS51096.1 - 0.072 13.8 0.1 0.24 12.0 0.1 1.9 1 0 0 1 1 1 0 Ead/Ea22-like protein Spc7 PF08317.11 AAS51096.1 - 0.081 11.8 7.2 0.23 10.3 7.2 1.7 1 0 0 1 1 1 0 Spc7 kinetochore protein Mce4_CUP1 PF11887.8 AAS51096.1 - 0.096 12.1 3.2 1.5 8.2 0.2 2.4 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative Leu_zip PF15294.6 AAS51096.1 - 0.63 9.5 11.7 0.014 14.9 3.9 2.2 2 0 0 2 2 2 0 Leucine zipper FAM76 PF16046.5 AAS51096.1 - 0.64 9.3 16.4 0.016 14.6 1.2 2.7 3 0 0 3 3 3 0 FAM76 protein Osteoregulin PF07175.11 AAS51096.1 - 0.7 10.1 8.9 0.83 9.8 6.9 2.1 2 0 0 2 2 2 0 Osteoregulin UPF0242 PF06785.11 AAS51096.1 - 1.3 9.1 10.5 0.08 13.0 1.3 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Swi5 PF07061.11 AAS51096.1 - 1.8 8.7 4.9 12 6.1 2.7 3.1 1 1 1 2 2 2 0 Swi5 JIP_LZII PF16471.5 AAS51096.1 - 3.4 7.9 10.2 0.69 10.1 4.3 2.8 2 1 1 3 3 2 0 JNK-interacting protein leucine zipper II PCRF PF03462.18 AAS51096.1 - 3.5 7.4 11.5 0.44 10.4 4.1 2.8 3 0 0 3 3 3 0 PCRF domain GrpE PF01025.19 AAS51096.1 - 5.7 6.6 9.8 1.6 8.3 3.7 2.9 3 0 0 3 3 3 0 GrpE CENP-H PF05837.12 AAS51096.1 - 6.5 7.2 11.8 4.5 7.7 8.4 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Thioredoxin PF00085.20 AAS51097.1 - 1.2e-31 108.7 0.3 1.4e-31 108.5 0.3 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AAS51097.1 - 8.7e-08 32.6 0.4 3.1e-07 30.8 0.4 1.7 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AAS51097.1 - 1e-06 28.7 0.2 1.6e-06 28.0 0.2 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 AAS51097.1 - 2.6e-06 27.6 0.1 0.00037 20.8 0.0 2.1 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 AAS51097.1 - 2.1e-05 24.0 0.1 2.3e-05 23.9 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DIM1 PF02966.16 AAS51097.1 - 2.3e-05 24.2 0.1 2.5e-05 24.1 0.1 1.1 1 0 0 1 1 1 1 Mitosis protein DIM1 Thioredoxin_9 PF14595.6 AAS51097.1 - 0.00016 21.5 0.0 0.00016 21.4 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 AAS51097.1 - 0.00087 19.0 0.1 0.0011 18.7 0.1 1.4 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 AAS51097.1 - 0.0042 17.0 0.0 0.006 16.5 0.0 1.2 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 AAS51097.1 - 0.0081 16.3 0.3 0.024 14.8 0.3 1.8 1 1 0 1 1 1 1 Thioredoxin-like TraF PF13728.6 AAS51097.1 - 0.01 15.6 0.1 0.014 15.3 0.1 1.1 1 0 0 1 1 1 0 F plasmid transfer operon protein DUF2847 PF11009.8 AAS51097.1 - 0.027 14.4 0.0 0.035 14.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) DUF4290 PF14123.6 AAS51097.1 - 0.04 13.5 0.0 0.049 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) Thioredoxin_6 PF13848.6 AAS51097.1 - 0.067 13.1 0.1 0.086 12.7 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Glutaredoxin PF00462.24 AAS51097.1 - 0.11 12.8 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Glutaredoxin Hydrolase PF00702.26 AAS51098.1 - 1.5e-18 67.9 1.1 2.5e-18 67.1 1.1 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AAS51098.1 - 4.8e-16 59.7 0.2 7.4e-16 59.1 0.2 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AAS51098.1 - 8.7e-07 28.9 0.1 1e-05 25.4 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AAS51098.1 - 8.9e-05 22.6 0.1 0.23 11.5 0.0 2.7 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AAS51098.1 - 0.00068 19.1 0.0 0.0013 18.2 0.0 1.4 1 1 0 1 1 1 1 Putative Phosphatase ETF PF01012.21 AAS51099.1 - 2.9e-38 131.6 6.9 3.6e-38 131.3 6.9 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain Mvb12 PF09452.10 AAS51100.1 - 3.4e-30 104.3 0.0 3.8e-30 104.2 0.0 1.0 1 0 0 1 1 1 1 ESCRT-I subunit Mvb12 3-HAO PF06052.12 AAS51101.1 - 3.7e-62 208.4 0.0 4.3e-62 208.2 0.0 1.0 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 AAS51101.1 - 1.1e-06 28.3 0.0 1.6e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AAS51101.1 - 0.0011 18.8 0.0 0.0019 18.1 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 AAS51101.1 - 0.0014 18.3 0.0 0.0018 17.9 0.0 1.2 1 0 0 1 1 1 1 Cupin FYVE PF01363.21 AAS51101.1 - 0.0074 16.4 1.4 0.012 15.8 1.4 1.2 1 0 0 1 1 1 1 FYVE zinc finger zf-ribbon_3 PF13248.6 AAS51101.1 - 0.056 12.9 0.1 0.13 11.7 0.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain Rpr2 PF04032.16 AAS51101.1 - 0.077 13.3 0.7 0.35 11.2 0.0 2.0 1 1 1 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-B_box PF00643.24 AAS51101.1 - 0.33 11.2 3.0 0.45 10.7 0.3 2.2 2 0 0 2 2 2 0 B-box zinc finger Aldolase_II PF00596.21 AAS51102.1 - 3.5e-46 157.5 0.0 4.1e-46 157.3 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain LSM PF01423.22 AAS51103.1 - 1.1e-09 37.9 0.0 1.4e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 LSM domain Mer2 PF09074.10 AAS51104.2 - 2e-27 96.3 0.6 2.2e-25 89.6 0.6 2.1 1 1 0 1 1 1 1 Mer2 AAA_16 PF13191.6 AAS51105.1 - 0.00016 22.1 0.3 0.00024 21.5 0.2 1.5 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 AAS51105.1 - 0.00026 20.3 0.0 0.00039 19.8 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_25 PF13481.6 AAS51105.1 - 0.00051 19.7 0.0 0.00095 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AAS51105.1 - 0.0012 18.5 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 AAS51105.1 - 0.0088 16.2 0.3 0.077 13.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 AAS51105.1 - 0.028 13.5 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 AAS51105.1 - 0.043 12.7 0.0 0.067 12.1 0.0 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_11 PF13086.6 AAS51105.1 - 0.084 12.6 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AAS51105.1 - 0.096 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AAS51105.1 - 0.13 11.8 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region ResIII PF04851.15 AAS51105.1 - 0.14 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATPase PF06745.13 AAS51105.1 - 0.24 10.7 0.0 0.33 10.2 0.0 1.1 1 0 0 1 1 1 0 KaiC 4HBT_3 PF13622.6 AAS51106.1 - 6.8e-21 75.6 0.0 5.5e-20 72.7 0.0 1.9 1 1 0 1 1 1 1 Thioesterase-like superfamily Acyl_CoA_thio PF02551.15 AAS51106.1 - 8.4e-16 58.0 0.0 1.1e-12 47.9 0.0 2.8 2 1 1 3 3 3 2 Acyl-CoA thioesterase FTHFS PF01268.19 AAS51107.2 - 2.8e-250 831.3 0.1 4.3e-250 830.6 0.1 1.3 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AAS51107.2 - 1.2e-60 203.4 0.2 1.2e-60 203.4 0.2 1.8 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AAS51107.2 - 2.6e-36 124.4 0.0 8.2e-36 122.8 0.0 1.9 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain CbiA PF01656.23 AAS51107.2 - 0.0025 17.9 0.0 0.038 14.0 0.0 2.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Helicase_C_4 PF13871.6 AAS51107.2 - 0.023 14.4 0.0 0.039 13.6 0.0 1.2 1 0 0 1 1 1 0 C-terminal domain on Strawberry notch homologue B12-binding PF02310.19 AAS51107.2 - 0.17 12.0 0.9 3.4 7.7 0.3 3.3 3 0 0 3 3 3 0 B12 binding domain Rotamase PF00639.21 AAS51108.1 - 4.2e-24 85.3 0.0 6.9e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 AAS51108.1 - 3e-19 69.7 0.0 4e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain WW PF00397.26 AAS51108.1 - 1.8e-10 40.7 2.2 2.8e-10 40.1 2.2 1.3 1 0 0 1 1 1 1 WW domain Rotamase_2 PF13145.6 AAS51108.1 - 1.2e-05 26.1 0.0 3.2e-05 24.7 0.0 1.6 2 0 0 2 2 2 1 PPIC-type PPIASE domain Glyco_hyd_101C PF17451.2 AAS51108.1 - 0.1 12.9 0.3 0.18 12.1 0.1 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain X8 PF07983.13 AAS51108.1 - 0.18 12.5 0.0 0.33 11.7 0.0 1.4 1 0 0 1 1 1 0 X8 domain Rhodanese PF00581.20 AAS51109.1 - 7.5e-11 42.5 0.0 9.1e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain CTP_transf_like PF01467.26 AAS51110.1 - 3.5e-33 114.8 0.0 5.6e-33 114.1 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase-like Trefoil PF00088.18 AAS51110.1 - 0.028 14.3 0.3 0.051 13.5 0.3 1.5 1 0 0 1 1 1 0 Trefoil (P-type) domain CTNNBL PF08216.11 AAS51110.1 - 0.037 14.2 0.2 0.078 13.2 0.2 1.5 1 0 0 1 1 1 0 Catenin-beta-like, Arm-motif containing nuclear ILVD_EDD PF00920.21 AAS51111.1 - 2.2e-211 703.0 0.1 2.5e-211 702.8 0.1 1.0 1 0 0 1 1 1 1 Dehydratase family WD40 PF00400.32 AAS51112.1 - 2.3e-32 110.5 21.4 0.0025 18.6 0.0 10.5 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51112.1 - 5.8e-12 45.7 4.2 1.3 9.3 0.0 8.0 5 4 3 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS51112.1 - 7.1e-05 21.9 0.0 3.4 6.5 0.0 4.8 7 0 0 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 AAS51112.1 - 0.092 13.3 0.2 0.32 11.5 0.2 2.0 1 0 0 1 1 1 0 PQQ-like domain Lipase_3 PF01764.25 AAS51114.1 - 3.6e-29 101.5 0.0 5.9e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AAS51114.1 - 4.8e-06 26.0 0.0 7e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 AAS51114.1 - 0.0038 17.4 0.2 0.0056 16.8 0.2 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF2974 PF11187.8 AAS51114.1 - 0.021 14.4 0.1 0.72 9.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) DUF1150 PF06620.11 AAS51114.1 - 0.036 14.2 0.0 0.068 13.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1150) Abhydrolase_3 PF07859.13 AAS51114.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold TPR_17 PF13431.6 AAS51115.1 - 4.4e-05 23.6 3.0 0.15 12.5 0.0 5.3 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51115.1 - 0.0044 17.7 0.6 9.8 7.3 0.0 5.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51115.1 - 0.0044 17.5 1.0 0.88 10.1 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 AAS51115.1 - 0.034 14.3 0.7 65 4.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Longin PF13774.6 AAS51115.1 - 0.056 13.5 0.2 7.4 6.7 0.0 2.6 2 0 0 2 2 2 0 Regulated-SNARE-like domain TPR_11 PF13414.6 AAS51115.1 - 0.084 12.6 0.0 0.3 10.8 0.0 2.0 1 0 0 1 1 1 0 TPR repeat TPR_16 PF13432.6 AAS51115.1 - 0.59 10.8 5.0 2.3 9.0 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat SUI1 PF01253.22 AAS51116.1 - 3.5e-21 75.5 0.8 8e-21 74.4 0.8 1.6 1 0 0 1 1 1 1 Translation initiation factor SUI1 MethyltransfD12 PF02086.15 AAS51116.1 - 0.16 11.6 0.3 0.36 10.5 0.1 1.6 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase Calcipressin PF04847.12 AAS51117.1 - 7.3e-12 45.4 0.1 1.4e-11 44.5 0.1 1.4 1 0 0 1 1 1 1 Calcipressin COX5A PF02284.16 AAS51118.1 - 6.3e-40 135.3 1.3 7.9e-40 135.0 1.3 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va DUF488 PF04343.13 AAS51118.1 - 0.042 14.4 0.7 0.52 10.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF488 Pyr_redox_2 PF07992.14 AAS51119.1 - 2.8e-51 174.5 0.1 3.2e-51 174.3 0.1 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AAS51119.1 - 6.5e-19 68.3 0.0 4.3e-16 59.2 0.0 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AAS51119.1 - 8.2e-15 54.8 0.0 2.5e-13 49.9 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AAS51119.1 - 1.7e-05 24.1 2.6 0.048 12.7 0.1 3.0 3 1 0 3 3 3 2 FAD binding domain GIDA PF01134.22 AAS51119.1 - 2.2e-05 23.8 0.5 0.62 9.1 0.1 3.8 4 0 0 4 4 4 2 Glucose inhibited division protein A NAD_binding_7 PF13241.6 AAS51119.1 - 0.0002 21.7 0.0 0.083 13.3 0.0 2.4 2 0 0 2 2 2 1 Putative NAD(P)-binding NAD_binding_8 PF13450.6 AAS51119.1 - 0.0005 20.2 0.0 0.046 14.0 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AAS51119.1 - 0.0035 16.6 0.0 0.013 14.7 0.0 1.8 2 0 0 2 2 2 1 Thi4 family FAD_binding_3 PF01494.19 AAS51119.1 - 0.0083 15.4 0.1 2.2 7.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain K_oxygenase PF13434.6 AAS51119.1 - 0.011 14.9 0.1 1.8 7.6 0.0 3.4 2 1 1 3 3 3 0 L-lysine 6-monooxygenase (NADPH-requiring) HI0933_like PF03486.14 AAS51119.1 - 0.025 13.3 0.1 2.8 6.6 0.1 2.9 3 0 0 3 3 3 0 HI0933-like protein DAO PF01266.24 AAS51119.1 - 0.027 14.0 1.1 0.18 11.3 1.1 2.3 1 1 0 1 1 1 0 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AAS51119.1 - 0.038 13.3 0.4 2.6 7.3 0.2 2.2 2 0 0 2 2 2 0 FAD dependent oxidoreductase LigB PF02900.18 AAS51119.1 - 0.066 12.3 0.0 0.11 11.6 0.0 1.3 1 0 0 1 1 1 0 Catalytic LigB subunit of aromatic ring-opening dioxygenase Shikimate_DH PF01488.20 AAS51119.1 - 0.073 13.1 0.2 12 6.0 0.0 2.7 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase PX PF00787.24 AAS51120.2 - 5.9e-15 55.2 0.0 7.1e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 PX domain Aldo_ket_red PF00248.21 AAS51121.1 - 1.2e-41 142.8 0.0 1.8e-41 142.2 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family PQ-loop PF04193.14 AAS51122.1 - 9e-37 124.7 6.0 1.9e-18 66.0 1.2 2.4 2 0 0 2 2 2 2 PQ loop repeat MtN3_slv PF03083.16 AAS51122.1 - 0.058 13.4 0.2 0.058 13.4 0.2 2.9 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange SBE2 PF17076.5 AAS51123.2 - 5.2e-178 593.9 8.9 2e-170 568.8 1.5 3.4 1 1 0 2 2 2 2 SBE2, cell-wall formation Pkinase PF00069.25 AAS51124.1 - 9.7e-69 231.7 0.0 1.5e-68 231.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51124.1 - 6.7e-53 179.6 0.0 1.2e-52 178.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51124.1 - 1.7e-06 27.6 0.1 0.0011 18.4 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AAS51124.1 - 1.8e-06 27.0 0.0 4.4e-05 22.4 0.0 2.3 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AAS51124.1 - 0.0027 17.6 0.1 0.92 9.4 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS51124.1 - 0.018 14.0 0.4 0.41 9.5 0.1 2.3 2 0 0 2 2 2 0 Haspin like kinase domain DSPc PF00782.20 AAS51126.2 - 2.2e-26 92.3 0.1 2e-25 89.1 0.1 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AAS51126.2 - 0.0086 15.7 0.0 0.013 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Zn_ribbon_SprT PF17283.2 AAS51126.2 - 0.033 14.1 0.3 0.033 14.1 0.3 3.0 3 0 0 3 3 3 0 SprT-like zinc ribbon domain Elf1 PF05129.13 AAS51126.2 - 0.033 14.2 0.8 5 7.2 0.1 3.0 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like Trm112p PF03966.16 AAS51126.2 - 0.044 14.4 0.0 0.1 13.2 0.0 1.7 1 1 0 1 1 1 0 Trm112p-like protein Yippee-Mis18 PF03226.14 AAS51126.2 - 0.059 13.6 1.4 0.3 11.3 1.4 2.0 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF674 PF05056.12 AAS51126.2 - 0.27 10.1 0.7 0.61 8.9 0.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF674) zinc_ribbon_4 PF13717.6 AAS51126.2 - 9.4 6.3 7.3 12 6.0 0.9 2.6 2 0 0 2 2 2 0 zinc-ribbon domain Apc15p PF05841.11 AAS51127.2 - 1.9e-14 54.5 0.2 3e-14 53.9 0.2 1.3 1 0 0 1 1 1 1 Apc15p protein DUF1748 PF08520.10 AAS51128.2 - 2.4e-21 75.4 0.2 3e-21 75.1 0.2 1.1 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) WD40 PF00400.32 AAS51129.2 - 9.4e-12 45.3 0.0 0.00099 19.9 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51129.2 - 8e-06 26.1 0.0 0.18 12.2 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Lactonase PF10282.9 AAS51129.2 - 0.00095 18.5 0.0 0.013 14.8 0.0 2.6 2 1 0 3 3 3 1 Lactonase, 7-bladed beta-propeller Cytochrom_D1 PF02239.16 AAS51129.2 - 0.047 12.2 0.0 1.1 7.8 0.0 2.7 2 1 0 3 3 3 0 Cytochrome D1 heme domain Frtz PF11768.8 AAS51129.2 - 0.24 9.7 0.0 0.58 8.4 0.0 1.6 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz AAA_11 PF13086.6 AAS51130.2 - 2.2e-58 198.1 0.0 4.4e-58 197.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 AAS51130.2 - 1.1e-56 191.6 0.0 1.9e-56 190.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS51130.2 - 3.9e-13 49.6 0.0 1.2e-10 41.5 0.0 3.3 1 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AAS51130.2 - 2.8e-12 47.2 0.0 1.8e-11 44.5 0.0 2.4 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 AAS51130.2 - 2.5e-07 30.7 0.1 0.2 11.3 0.0 3.4 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 AAS51130.2 - 6.7e-05 23.2 0.1 0.0068 16.7 0.0 3.2 3 0 0 3 3 3 1 AAA domain UvrD-helicase PF00580.21 AAS51130.2 - 0.0002 21.0 0.0 0.0012 18.5 0.0 2.0 1 1 0 1 1 1 1 UvrD/REP helicase N-terminal domain ResIII PF04851.15 AAS51130.2 - 0.00031 20.8 0.0 0.00084 19.4 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit PhoH PF02562.16 AAS51130.2 - 0.00062 19.3 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein Helicase_RecD PF05127.14 AAS51130.2 - 0.0012 18.7 0.0 0.013 15.3 0.0 2.7 2 1 0 3 3 3 1 Helicase AAA_16 PF13191.6 AAS51130.2 - 0.0019 18.6 0.4 0.0086 16.5 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain cobW PF02492.19 AAS51130.2 - 0.0022 17.6 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain TrwB_AAD_bind PF10412.9 AAS51130.2 - 0.0023 16.9 0.0 0.0043 16.0 0.0 1.4 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain IstB_IS21 PF01695.17 AAS51130.2 - 0.0057 16.4 0.0 0.022 14.5 0.0 2.0 1 0 0 1 1 1 1 IstB-like ATP binding protein Flavi_DEAD PF07652.14 AAS51130.2 - 0.0086 16.1 0.0 0.022 14.7 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain AAA_24 PF13479.6 AAS51130.2 - 0.012 15.3 0.0 0.13 11.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain UvrD_C_2 PF13538.6 AAS51130.2 - 0.013 15.3 0.0 0.036 13.9 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA PF00004.29 AAS51130.2 - 0.019 15.4 0.1 0.15 12.5 0.0 2.6 3 0 0 3 3 1 0 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 AAS51130.2 - 0.028 13.7 1.0 0.19 11.0 0.0 2.6 3 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) CbiA PF01656.23 AAS51130.2 - 0.038 14.0 0.0 0.075 13.1 0.0 1.6 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 AAS51130.2 - 0.077 12.0 0.0 0.16 10.9 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 AAS51130.2 - 0.12 12.6 0.0 0.34 11.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain DUF853 PF05872.12 AAS51130.2 - 0.12 11.0 0.0 0.21 10.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Hydin_ADK PF17213.3 AAS51130.2 - 0.13 12.6 0.0 1.2 9.4 0.0 2.4 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain PIF1 PF05970.14 AAS51130.2 - 0.15 11.2 0.0 3.1 6.9 0.0 2.2 2 0 0 2 2 2 0 PIF1-like helicase DEAD PF00270.29 AAS51130.2 - 0.17 11.7 0.0 0.58 9.9 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase Mt_ATP-synt_D PF05873.12 AAS51131.1 - 5.8e-19 68.5 1.2 7.6e-19 68.1 1.2 1.1 1 0 0 1 1 1 1 ATP synthase D chain, mitochondrial (ATP5H) LTXXQ PF07813.12 AAS51131.1 - 0.0012 19.6 1.5 1.5 9.6 0.1 2.1 2 0 0 2 2 2 2 LTXXQ motif family protein Dor1 PF04124.12 AAS51131.1 - 0.058 12.1 0.6 0.07 11.8 0.6 1.1 1 0 0 1 1 1 0 Dor1-like family Fungal_trans PF04082.18 AAS51132.2 - 3.3e-13 49.3 0.7 5.7e-13 48.5 0.7 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS51132.2 - 2.3e-09 37.2 5.5 4.4e-09 36.3 5.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain APG6_N PF17675.1 AAS51132.2 - 5.8 7.5 8.5 16 6.0 0.1 2.3 2 0 0 2 2 2 0 Apg6 coiled-coil region Npa1 PF11707.8 AAS51133.1 - 1.3e-92 310.8 0.9 2.6e-92 309.8 0.9 1.6 1 0 0 1 1 1 1 Ribosome 60S biogenesis N-terminal NopRA1 PF16201.5 AAS51133.1 - 3.2e-47 160.7 0.1 1.2e-46 158.8 0.1 2.1 1 0 0 1 1 1 1 Nucleolar pre-ribosomal-associated protein 1 DUF4604 PF15377.6 AAS51134.1 - 1.6 9.1 3.9 1.5 9.2 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4604) Fungal_trans PF04082.18 AAS51135.2 - 3.4e-24 85.3 1.1 6.3e-24 84.4 1.1 1.5 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS51135.2 - 1.4e-05 25.1 8.2 2.8e-05 24.1 8.2 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain ARPC4 PF05856.12 AAS51136.2 - 7.8e-71 237.1 2.9 8.7e-71 236.9 2.9 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Metallophos PF00149.28 AAS51137.1 - 2e-12 48.1 1.2 2e-12 48.1 1.2 2.4 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase Suf PF05843.14 AAS51139.3 - 0.0007 19.7 0.0 0.97 9.4 0.0 2.7 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) LRR_4 PF12799.7 AAS51140.1 - 0.00035 20.9 18.2 0.42 11.1 0.2 6.5 6 1 0 7 7 7 3 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 AAS51140.1 - 0.027 15.1 0.8 32 5.4 0.0 4.5 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_1 PF00560.33 AAS51140.1 - 7.2 7.6 14.2 77 4.4 0.2 6.5 7 2 0 7 7 7 0 Leucine Rich Repeat Ras PF00071.22 AAS51141.1 - 9.4e-49 165.1 0.0 1.1e-48 164.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51141.1 - 2e-22 79.6 0.0 2.7e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51141.1 - 2.3e-07 30.5 0.0 3.3e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family PduV-EutP PF10662.9 AAS51141.1 - 0.0013 18.5 0.0 3.3 7.4 0.0 2.7 2 1 0 3 3 3 2 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.10 AAS51141.1 - 0.033 13.6 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_21 PF13304.6 AAS51141.1 - 0.25 11.1 0.0 0.3 10.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system NST1 PF13945.6 AAS51142.2 - 4.8e-15 56.2 3.4 4.8e-15 56.2 3.4 4.6 3 1 2 5 5 5 1 Salt tolerance down-regulator N2227 PF07942.12 AAS51143.1 - 1.5e-107 358.9 0.1 1.8e-107 358.6 0.1 1.1 1 0 0 1 1 1 1 N2227-like protein Methyltransf_11 PF08241.12 AAS51143.1 - 0.098 13.3 0.0 5.7 7.6 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Ras PF00071.22 AAS51144.1 - 3.8e-60 202.1 0.0 4.5e-60 201.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51144.1 - 9.9e-36 122.6 0.0 1.4e-35 122.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51144.1 - 1.2e-17 63.9 0.0 1.4e-17 63.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS51144.1 - 2.5e-07 30.3 0.0 3.2e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AAS51144.1 - 8.4e-06 25.5 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS51144.1 - 1.1e-05 25.4 0.1 0.0094 15.9 0.0 2.1 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AAS51144.1 - 6.9e-05 22.9 0.0 0.00012 22.2 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS51144.1 - 0.055 13.8 0.1 0.079 13.3 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain PP2C PF00481.21 AAS51145.1 - 9.3e-46 156.5 0.0 1.5e-45 155.9 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DFRP_C PF16543.5 AAS51146.1 - 4.8e-25 87.9 7.7 4.8e-25 87.9 7.7 3.6 3 1 1 4 4 4 1 DRG Family Regulatory Proteins, Tma46 zf-CCCH PF00642.24 AAS51146.1 - 4e-05 23.4 0.2 4e-05 23.4 0.2 2.1 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 AAS51146.1 - 6.1e-05 23.7 10.2 0.0012 19.5 2.7 3.2 2 1 1 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 AAS51146.1 - 0.00011 22.1 14.3 0.00013 21.8 4.2 3.2 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 AAS51146.1 - 0.00017 21.3 8.0 0.013 15.3 1.0 3.4 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 AAS51146.1 - 0.046 14.2 9.9 1.4 9.5 2.0 3.0 2 1 0 2 2 2 0 RNA-binding, Nab2-type zinc finger zf-CCCH_3 PF15663.5 AAS51146.1 - 0.93 9.7 7.4 2.2 8.5 0.3 2.7 2 1 1 3 3 3 0 Zinc-finger containing family DUF2183 PF09949.9 AAS51147.2 - 2.1e-31 108.2 0.1 9.3e-31 106.1 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2183) LNS2 PF08235.13 AAS51147.2 - 0.034 13.6 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) LYTB PF02401.18 AAS51147.2 - 0.082 12.2 0.2 0.13 11.5 0.2 1.2 1 0 0 1 1 1 0 LytB protein Mem_trans PF03547.18 AAS51148.2 - 1.4e-23 82.9 1.6 9.9e-23 80.1 1.6 1.9 1 1 0 1 1 1 1 Membrane transport protein AMP-binding PF00501.28 AAS51149.2 - 1.6e-42 145.6 0.0 9.8e-16 57.4 0.0 5.1 5 0 0 5 5 5 5 AMP-binding enzyme DMAP_binding PF06464.11 AAS51149.2 - 8.8e-06 26.5 0.0 3.4e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 DMAP1-binding Domain ExbD PF02472.16 AAS51149.2 - 0.1 12.8 0.1 20 5.4 0.0 2.9 3 0 0 3 3 3 0 Biopolymer transport protein ExbD/TolR Arf PF00025.21 AAS51150.1 - 2.8e-70 235.3 0.1 3.1e-70 235.2 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AAS51150.1 - 1e-15 58.0 0.0 1.4e-15 57.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 AAS51150.1 - 4.2e-14 52.5 0.4 3.1e-09 36.5 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AAS51150.1 - 1.2e-13 51.0 0.0 1.4e-13 50.8 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AAS51150.1 - 3.7e-13 49.3 0.0 4.6e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 AAS51150.1 - 4.9e-10 39.2 0.0 6.4e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS51150.1 - 8.4e-06 25.9 0.0 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Rib_5-P_isom_A PF06026.14 AAS51151.1 - 3.9e-57 192.6 0.0 4.8e-57 192.3 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 AAS51151.1 - 0.0065 16.4 0.0 0.15 12.0 0.0 2.2 1 1 0 1 1 1 1 DeoR C terminal sensor domain Ribosomal_S7e PF01251.18 AAS51152.1 - 8.7e-81 270.1 2.0 1e-80 269.9 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e SRP40_C PF05022.12 AAS51154.2 - 1.3e-23 83.6 3.7 3.1e-23 82.4 3.7 1.7 1 0 0 1 1 1 1 SRP40, C-terminal domain AA_permease_2 PF13520.6 AAS51155.2 - 7e-71 239.3 38.3 8.7e-71 239.0 38.3 1.1 1 0 0 1 1 1 1 Amino acid permease SID-1_RNA_chan PF13965.6 AAS51155.2 - 0.0073 14.8 1.0 0.0073 14.8 1.0 2.0 2 0 0 2 2 2 1 dsRNA-gated channel SID-1 ABC_tran PF00005.27 AAS51156.2 - 5.5e-58 195.4 0.7 5.8e-34 117.5 0.0 3.4 3 0 0 3 3 3 2 ABC transporter ABC_membrane PF00664.23 AAS51156.2 - 2.3e-54 184.9 34.6 4.7e-34 118.3 9.9 3.2 3 0 0 3 3 3 2 ABC transporter transmembrane region AAA_23 PF13476.6 AAS51156.2 - 3e-07 31.2 1.1 0.026 15.0 0.1 2.7 2 0 0 2 2 2 2 AAA domain SMC_N PF02463.19 AAS51156.2 - 3e-07 30.1 10.1 0.004 16.6 3.2 4.5 4 1 0 4 4 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AAS51156.2 - 3.2e-07 30.5 0.5 0.12 12.1 0.0 3.5 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AAS51156.2 - 2.1e-06 27.4 0.2 0.0059 16.3 0.0 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AAS51156.2 - 9.9e-06 25.6 0.0 0.03 14.2 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AAS51156.2 - 1.1e-05 25.5 0.1 0.0056 16.7 0.0 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_15 PF13175.6 AAS51156.2 - 0.00016 21.5 2.5 0.029 14.1 0.3 2.5 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 AAS51156.2 - 0.00035 21.0 0.0 0.44 10.9 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AAS51156.2 - 0.00097 19.4 0.2 3 8.1 0.1 3.1 2 1 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AAS51156.2 - 0.0018 17.8 0.2 0.7 9.4 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF87 PF01935.17 AAS51156.2 - 0.0027 17.9 0.1 1.5 8.8 0.0 2.5 2 0 0 2 2 2 1 Helicase HerA, central domain AAA_24 PF13479.6 AAS51156.2 - 0.0029 17.4 4.3 0.015 15.1 0.2 3.0 3 1 0 3 3 3 1 AAA domain AAA_25 PF13481.6 AAS51156.2 - 0.0086 15.7 0.0 0.11 12.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 AAS51156.2 - 0.011 14.8 0.0 2.3 7.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA PF00004.29 AAS51156.2 - 0.015 15.7 0.2 18 5.8 0.0 3.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AAS51156.2 - 0.019 14.7 0.0 9.2 5.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 AAS51156.2 - 0.031 14.1 0.1 14 5.4 0.0 3.2 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein Adeno_IVa2 PF02456.15 AAS51156.2 - 0.042 12.7 0.1 1 8.1 0.0 2.2 2 0 0 2 2 2 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 AAS51156.2 - 0.047 13.0 0.1 0.43 9.8 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 AAS51156.2 - 0.059 13.1 0.0 0.32 10.7 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain Dynamin_N PF00350.23 AAS51156.2 - 0.061 13.4 0.6 4.2 7.4 0.1 2.6 2 0 0 2 2 2 0 Dynamin family RRM_1 PF00076.22 AAS51157.1 - 8e-16 57.6 4.3 4.3e-10 39.3 0.2 3.3 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS51157.1 - 0.019 15.1 0.2 0.68 10.1 0.0 2.4 2 1 0 2 2 2 0 RNA recognition motif RRM_Rrp7 PF17799.1 AAS51157.1 - 0.024 14.4 0.1 2.2 8.1 0.0 2.6 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain Trypan_PARP PF05887.11 AAS51157.1 - 0.024 14.6 0.3 0.045 13.7 0.3 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Ribosomal_L7Ae PF01248.26 AAS51158.1 - 5.8e-23 80.4 0.3 1.1e-22 79.6 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 AAS51158.1 - 0.0031 17.6 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 RNase P subunit Pop3 CCDC106 PF15794.5 AAS51158.1 - 0.019 14.7 0.1 0.029 14.1 0.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF2457 PF10446.9 AAS51158.1 - 7.3 5.6 8.6 12 4.9 8.4 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) FGGY_C PF02782.16 AAS51159.2 - 2e-72 243.1 0.2 3e-72 242.5 0.2 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AAS51159.2 - 3.6e-55 187.2 0.0 1.7e-46 158.8 0.0 2.5 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 AAS51159.2 - 0.014 14.9 0.0 0.062 12.8 0.0 2.1 3 0 0 3 3 3 0 BadF/BadG/BcrA/BcrD ATPase family MIP PF00230.20 AAS51160.2 - 4.1e-59 200.1 6.3 5.8e-59 199.6 6.3 1.1 1 0 0 1 1 1 1 Major intrinsic protein V-SNARE_C PF12352.8 AAS51161.2 - 1.5e-19 70.0 11.4 2.2e-16 59.9 1.3 2.5 2 0 0 2 2 2 2 Snare region anchored in the vesicle membrane C-terminus RseA_N PF03872.13 AAS51161.2 - 0.0025 18.3 1.4 0.0046 17.4 1.4 1.5 1 0 0 1 1 1 1 Anti sigma-E protein RseA, N-terminal domain DUF2408 PF10303.9 AAS51161.2 - 0.055 14.0 7.9 0.15 12.6 1.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Sec20 PF03908.13 AAS51161.2 - 0.15 12.0 3.8 0.19 11.7 0.1 2.4 2 1 0 2 2 2 0 Sec20 GAS PF13851.6 AAS51161.2 - 2.8 7.3 14.1 7.7 5.8 9.5 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Autophagy_act_C PF03987.15 AAS51162.2 - 9.4e-06 26.1 0.8 1.9e-05 25.1 0.8 1.6 1 0 0 1 1 1 1 Autophagocytosis associated protein, active-site domain Fer2_3 PF13085.6 AAS51163.1 - 9.2e-35 118.9 0.1 1.5e-34 118.3 0.1 1.3 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_17 PF13534.6 AAS51163.1 - 5.1e-10 39.7 7.2 5.1e-10 39.7 7.2 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AAS51163.1 - 8.3e-08 32.6 8.6 8.3e-08 32.6 8.6 2.5 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AAS51163.1 - 3.2e-07 30.3 4.4 3.2e-07 30.3 4.4 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.27 AAS51163.1 - 0.0099 15.8 1.1 0.0099 15.8 1.1 2.4 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_7 PF12838.7 AAS51163.1 - 0.039 14.5 10.0 0.039 14.5 10.0 2.9 2 2 0 2 2 2 0 4Fe-4S dicluster domain Fer4_9 PF13187.6 AAS51163.1 - 0.05 13.8 13.3 0.036 14.2 9.0 2.6 2 1 0 2 2 2 0 4Fe-4S dicluster domain SF3a60_bindingd PF12108.8 AAS51163.1 - 0.15 12.0 0.3 0.26 11.2 0.3 1.4 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain SHR-BD PF06650.12 AAS51164.2 - 3.6e-97 325.0 0.8 4.5e-94 314.8 0.0 3.7 4 0 0 4 4 4 2 SHR-binding domain of vacuolar-sorting associated protein 13 VPS13_mid_rpt PF16910.5 AAS51164.2 - 3.9e-78 262.1 0.2 3.9e-78 262.1 0.2 3.7 5 0 0 5 5 5 1 Repeating coiled region of VPS13 VPS13_C PF16909.5 AAS51164.2 - 1.5e-74 249.6 12.7 2.4e-70 235.9 0.9 3.8 4 0 0 4 4 4 2 Vacuolar-sorting-associated 13 protein C-terminal VPS13 PF16908.5 AAS51164.2 - 7.8e-74 248.4 8.6 2.4e-72 243.6 2.4 3.8 4 0 0 4 4 4 2 Vacuolar sorting-associated protein 13, N-terminal Chorein_N PF12624.7 AAS51164.2 - 2.9e-37 127.3 0.1 1.4e-36 125.1 0.0 2.4 2 0 0 2 2 2 1 N-terminal region of Chorein or VPS13 ATG_C PF09333.11 AAS51164.2 - 0.09 13.1 0.1 0.25 11.7 0.1 1.7 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Nnf1 PF03980.14 AAS51164.2 - 0.17 12.2 1.6 7.9 6.9 0.4 2.7 2 0 0 2 2 2 0 Nnf1 Ecm29 PF13001.7 AAS51165.2 - 1.1e-136 456.5 0.0 3.6e-136 454.7 0.0 2.0 1 0 0 1 1 1 1 Proteasome stabiliser HEAT PF02985.22 AAS51165.2 - 5.1e-10 38.7 0.7 0.34 11.3 0.0 7.9 6 0 0 6 6 6 2 HEAT repeat Vac14_Fab1_bd PF12755.7 AAS51165.2 - 0.00018 22.0 0.2 0.2 12.2 0.0 4.9 6 0 0 6 6 6 1 Vacuolar 14 Fab1-binding region TAF6_C PF07571.13 AAS51165.2 - 0.0022 18.3 0.1 2.7 8.4 0.1 4.5 4 0 0 4 4 4 1 TAF6 C-terminal HEAT repeat domain ubiquitin PF00240.23 AAS51166.1 - 4.7e-168 545.3 27.6 4.8e-33 112.7 0.6 5.0 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 AAS51166.1 - 4.4e-79 260.3 28.3 2.9e-15 55.8 0.7 5.0 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AAS51166.1 - 8e-28 96.7 14.7 0.00061 20.2 0.1 6.9 5 5 0 5 5 5 5 Ubiquitin-like domain TBK1_ULD PF18396.1 AAS51166.1 - 5.5e-20 71.1 5.5 0.038 13.9 0.0 5.2 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 AAS51166.1 - 2.7e-18 66.1 11.7 0.042 14.2 0.1 5.1 5 0 0 5 5 5 5 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AAS51166.1 - 2.2e-17 63.1 4.7 0.18 11.9 0.0 6.0 5 4 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AAS51166.1 - 7.2e-16 58.7 2.8 0.49 11.0 0.0 5.2 1 1 3 5 5 5 5 DUF2407 ubiquitin-like domain Methyltrans_RNA PF04452.14 AAS51166.1 - 3.1e-08 33.2 1.3 2.6 7.3 0.0 4.2 4 0 0 4 4 4 4 RNA methyltransferase Ubiquitin_4 PF18036.1 AAS51166.1 - 1e-07 31.9 32.0 22 5.2 0.2 9.9 10 0 0 10 10 10 0 Ubiquitin-like domain DUF2870 PF11069.8 AAS51166.1 - 2.4e-07 31.0 0.0 40 4.7 0.0 5.6 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) DUF3861 PF12977.7 AAS51166.1 - 5.4e-07 29.7 5.3 18 5.6 0.0 5.2 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) ACT_5 PF13710.6 AAS51166.1 - 1.7e-06 27.8 7.7 14 5.7 0.0 5.3 5 0 0 5 5 5 0 ACT domain Big_7 PF17957.1 AAS51166.1 - 2.5e-06 28.2 0.6 71 4.3 0.0 5.1 5 0 0 5 5 5 0 Bacterial Ig domain UDP-g_GGTase PF06427.11 AAS51166.1 - 1.4e-05 25.1 7.4 9.9 6.3 0.0 4.9 5 0 0 5 5 5 0 UDP-glucose:Glycoprotein Glucosyltransferase DUF969 PF06149.12 AAS51166.1 - 2.2e-05 24.0 0.0 32 3.8 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF969) DUF493 PF04359.14 AAS51166.1 - 0.00037 21.0 0.1 1.9e+02 2.7 0.0 4.9 5 0 0 5 5 5 0 Protein of unknown function (DUF493) YcgR_2 PF12945.7 AAS51166.1 - 0.00041 20.4 9.7 38 4.5 0.1 5.2 5 0 0 5 5 5 0 Flagellar protein YcgR ORF11CD3 PF10549.9 AAS51166.1 - 0.00068 19.7 0.0 1.2e+02 2.9 0.0 5.1 5 0 0 5 5 5 0 ORF11CD3 domain ACT_4 PF13291.6 AAS51166.1 - 0.0018 18.8 2.5 1.9e+02 2.7 0.0 5.1 5 0 0 5 5 5 0 ACT domain Baculo_p48 PF04878.13 AAS51166.1 - 0.024 13.6 0.0 85 1.9 0.0 3.8 4 0 0 4 4 4 0 Baculovirus P48 protein ProRS-C_2 PF09181.10 AAS51166.1 - 0.14 12.3 9.2 1.4e+02 2.7 0.1 5.0 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal Tash_PEST PF07708.11 AAS51166.1 - 0.19 11.9 36.0 8 6.8 1.4 5.3 5 0 0 5 5 5 0 Tash protein PEST motif HAMP_N3 PF18575.1 AAS51166.1 - 0.23 11.0 3.3 2.6e+02 1.3 0.0 4.7 5 0 0 5 5 5 0 HAMP N-terminal domain 3 Myosin_N PF02736.19 AAS51166.1 - 0.29 11.0 9.4 1.4e+02 2.4 0.0 6.1 5 0 0 5 5 5 0 Myosin N-terminal SH3-like domain PI3K_p85B PF02192.16 AAS51166.1 - 5.7 6.7 13.6 1.3e+02 2.4 0.1 5.1 5 0 0 5 5 5 0 PI3-kinase family, p85-binding domain ENTH PF01417.20 AAS51167.1 - 4.9e-29 100.9 0.1 6e-29 100.6 0.1 1.1 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 AAS51167.1 - 0.049 12.6 0.1 0.065 12.2 0.1 1.1 1 0 0 1 1 1 0 ANTH domain DUF3418 PF11898.8 AAS51167.1 - 0.05 12.3 0.0 0.061 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) VHS PF00790.19 AAS51167.1 - 0.099 12.5 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 VHS domain Prp19 PF08606.11 AAS51168.1 - 1.8e-30 104.7 1.3 3.4e-30 103.8 1.3 1.5 1 0 0 1 1 1 1 Prp19/Pso4-like U-box PF04564.15 AAS51168.1 - 0.0036 17.4 0.1 0.009 16.2 0.1 1.6 1 0 0 1 1 1 1 U-box domain DUF3435 PF11917.8 AAS51168.1 - 0.035 13.0 0.4 0.058 12.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) zf-Nse PF11789.8 AAS51168.1 - 0.092 12.6 0.3 0.22 11.4 0.1 1.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit Cys_Met_Meta_PP PF01053.20 AAS51169.1 - 3.5e-118 394.5 0.0 4e-118 394.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Fungal_trans PF04082.18 AAS51170.2 - 4.2e-08 32.5 0.0 8.5e-08 31.5 0.0 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS51170.2 - 4.5e-07 29.9 11.2 9.9e-07 28.8 11.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FlgT_N PF16548.5 AAS51170.2 - 0.22 12.1 2.9 0.84 10.3 2.9 1.9 1 0 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain zf-C2H2 PF00096.26 AAS51171.1 - 3.8e-13 49.1 9.5 4.8e-06 26.7 0.5 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS51171.1 - 7.7e-10 38.8 8.1 0.00017 22.2 0.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS51171.1 - 2.4e-08 34.1 11.5 3.3e-07 30.4 1.0 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS51171.1 - 1.2e-05 25.5 11.3 0.002 18.4 0.3 2.9 3 0 0 3 3 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AAS51171.1 - 0.00015 21.7 7.6 0.0011 18.9 0.4 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-Di19 PF05605.12 AAS51171.1 - 0.00045 20.5 1.0 0.00087 19.5 1.0 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.15 AAS51171.1 - 0.0021 18.0 5.5 0.64 10.1 0.2 2.5 2 0 0 2 2 2 2 BED zinc finger zf-met PF12874.7 AAS51171.1 - 0.023 15.1 13.2 0.12 12.8 0.4 3.5 4 0 0 4 4 3 0 Zinc-finger of C2H2 type zf-C2HE PF16278.5 AAS51171.1 - 0.033 14.6 3.6 0.71 10.4 0.4 2.9 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2HC_2 PF13913.6 AAS51171.1 - 0.11 12.5 7.1 4.1 7.4 0.1 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Actin_micro PF17003.5 AAS51171.1 - 0.17 11.0 0.9 0.41 9.8 0.9 1.5 1 1 0 1 1 1 0 Putative actin-like family zf-C2H2_2 PF12756.7 AAS51171.1 - 0.18 12.1 3.7 5 7.5 0.4 2.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 AAS51171.1 - 0.19 11.5 5.8 1.2 8.9 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain DUF629 PF04780.12 AAS51171.1 - 0.28 9.7 3.6 2.6 6.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF629) HNH PF01844.23 AAS51171.1 - 0.44 10.8 4.8 11 6.3 0.5 2.5 2 0 0 2 2 2 0 HNH endonuclease zf-CHCC PF10276.9 AAS51171.1 - 1.2 9.2 5.2 1.3 9.1 0.3 3.0 3 0 0 3 3 3 0 Zinc-finger domain PyrI_C PF02748.15 AAS51171.1 - 1.8 8.5 8.8 3.4 7.6 1.4 3.3 2 1 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Mnd1 PF03962.15 AAS51172.2 - 8.1e-28 96.5 1.3 1.6e-27 95.5 1.3 1.5 1 0 0 1 1 1 1 Mnd1 HTH domain AIP3 PF03915.13 AAS51172.2 - 0.00017 20.8 0.8 0.0002 20.6 0.8 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 DsrD PF08679.11 AAS51172.2 - 0.02 15.1 0.3 0.076 13.3 0.2 2.0 2 0 0 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) Tho1_MOS11_C PF18592.1 AAS51172.2 - 0.025 14.4 0.7 0.17 11.7 0.1 2.4 2 0 0 2 2 2 0 Tho1/MOS11 C-terminal domain GrpE PF01025.19 AAS51172.2 - 0.028 14.1 1.0 0.05 13.3 1.0 1.3 1 0 0 1 1 1 0 GrpE Seryl_tRNA_N PF02403.22 AAS51172.2 - 0.092 13.0 3.8 0.12 12.6 1.3 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PHM7_cyt PF14703.6 AAS51172.2 - 0.23 11.7 3.5 3.5 7.8 0.5 2.3 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Cep57_MT_bd PF06657.13 AAS51172.2 - 1.7 9.1 5.8 6.6 7.3 0.5 3.0 3 0 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Jnk-SapK_ap_N PF09744.9 AAS51172.2 - 2.1 8.5 8.3 1.7 8.9 3.8 2.4 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 ArfGap PF01412.18 AAS51173.1 - 1.6e-29 102.4 0.0 1.6e-29 102.4 0.0 2.8 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf UBA PF00627.31 AAS51173.1 - 0.0026 17.6 0.0 0.0073 16.2 0.0 1.8 1 0 0 1 1 1 1 UBA/TS-N domain Vma12 PF11712.8 AAS51173.1 - 0.026 14.6 0.0 0.026 14.6 0.0 2.2 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF3543 PF12063.8 AAS51174.1 - 4.5e-89 298.1 0.4 8.8e-89 297.2 0.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3543) Pkinase PF00069.25 AAS51174.1 - 8.9e-58 195.7 0.0 1.9e-57 194.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51174.1 - 2.7e-43 148.2 0.0 5.2e-43 147.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase MIT PF04212.18 AAS51174.1 - 0.034 14.2 4.2 1.3 9.1 0.2 3.7 2 2 0 2 2 2 0 MIT (microtubule interacting and transport) domain Pkinase PF00069.25 AAS51175.2 - 6.8e-54 183.0 0.0 1.5e-53 181.8 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51175.2 - 2.6e-26 92.4 0.1 1.9e-24 86.4 0.1 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS51175.2 - 0.0006 18.7 0.0 0.0028 16.5 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AAS51175.2 - 0.011 15.0 0.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Vfa1 PF08432.10 AAS51176.1 - 7.9e-32 111.0 0.6 9.4e-32 110.8 0.6 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Sas10_Utp3 PF04000.15 AAS51177.1 - 4e-11 43.4 0.2 2.2e-10 41.0 0.0 2.1 2 0 0 2 2 2 1 Sas10/Utp3/C1D family DASH_Spc19 PF08287.11 AAS51177.1 - 4.5 7.1 7.1 1.3 8.9 0.3 2.8 3 0 0 3 3 3 0 Spc19 Ribosomal_S8e PF01201.22 AAS51178.1 - 1.1e-46 158.4 0.1 2.1e-46 157.5 0.0 1.4 1 1 1 2 2 2 1 Ribosomal protein S8e DUF3746 PF12562.8 AAS51178.1 - 0.11 12.4 0.2 0.28 11.1 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) LCCL PF03815.19 AAS51180.2 - 2.6e-11 43.5 0.0 4.1e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 LCCL domain Sec6 PF06046.13 AAS51181.2 - 2.2e-167 557.9 15.0 2.7e-167 557.6 15.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 P22_AR_C PF10548.9 AAS51181.2 - 0.094 12.9 0.1 0.34 11.1 0.1 2.0 1 0 0 1 1 1 0 P22AR C-terminal domain TFB6 PF17110.5 AAS51181.2 - 0.36 10.6 5.6 7.9 6.2 0.0 4.3 5 0 0 5 5 5 0 Subunit 11 of the general transcription factor TFIIH Tctex-1 PF03645.13 AAS51182.2 - 9.7e-08 32.2 0.0 1.2e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Tctex-1 family DUF202 PF02656.15 AAS51183.1 - 1.3e-14 54.4 4.2 1.3e-14 54.4 4.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Aldedh PF00171.22 AAS51184.1 - 6.2e-185 615.1 0.1 7e-185 614.9 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family ESAG1 PF03238.13 AAS51184.1 - 0.14 11.6 0.2 0.38 10.2 0.0 1.8 2 0 0 2 2 2 0 ESAG protein Ribosomal_S24e PF01282.19 AAS51185.1 - 1.5e-36 124.2 0.1 2.4e-36 123.5 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S24e Yos1 PF08571.10 AAS51186.1 - 7.3e-33 112.7 2.1 8.1e-33 112.5 2.1 1.0 1 0 0 1 1 1 1 Yos1-like DUF3671 PF12420.8 AAS51186.1 - 0.11 12.5 0.4 0.15 12.1 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function Y_phosphatase PF00102.27 AAS51187.2 - 4.4e-52 177.0 0.0 6.3e-52 176.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 AAS51187.2 - 2.5e-09 37.6 0.0 8e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 Rhodanese-like domain DSPc PF00782.20 AAS51187.2 - 0.00083 19.2 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AAS51187.2 - 0.019 15.0 0.0 0.042 13.8 0.0 1.5 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-CCHC PF00098.23 AAS51188.1 - 1.5e-06 28.0 15.6 0.0001 22.2 3.0 5.2 5 1 0 5 5 5 3 Zinc knuckle Elongin_A PF06881.11 AAS51188.1 - 0.0088 16.5 0.1 0.0088 16.5 0.1 1.9 2 0 0 2 2 2 1 RNA polymerase II transcription factor SIII (Elongin) subunit A zf-C2H2_10 PF16588.5 AAS51188.1 - 0.01 15.5 3.0 0.01 15.5 3.0 5.0 5 1 1 6 6 6 0 C2H2 zinc-finger zf-CCHC_2 PF13696.6 AAS51188.1 - 0.016 15.0 5.1 0.016 15.0 5.1 5.3 5 0 0 5 5 5 0 Zinc knuckle tRNA-synt_2b PF00587.25 AAS51189.1 - 4.9e-36 124.4 0.0 8.9e-36 123.5 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AAS51189.1 - 1.8e-18 66.5 0.2 4.9e-18 65.1 0.2 1.8 1 0 0 1 1 1 1 Anticodon binding domain tRNA_SAD PF07973.14 AAS51189.1 - 1.7e-12 47.2 0.0 3.2e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain TGS PF02824.21 AAS51189.1 - 3e-11 43.2 0.0 6.9e-11 42.0 0.0 1.7 1 0 0 1 1 1 1 TGS domain DUF1689 PF07954.11 AAS51190.1 - 1.4e-40 139.1 0.0 2e-40 138.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) Coatomer_E PF04733.14 AAS51191.1 - 9.2e-13 48.2 8.0 2.4e-12 46.9 8.0 1.6 1 1 0 1 1 1 1 Coatomer epsilon subunit GET2 PF08690.10 AAS51192.1 - 2.2e-74 251.0 0.0 2.8e-74 250.6 0.0 1.2 1 0 0 1 1 1 1 GET complex subunit GET2 DHO_dh PF01180.21 AAS51193.1 - 6e-98 327.7 0.0 7.7e-98 327.3 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.18 AAS51193.1 - 6.9e-06 25.3 0.0 0.0066 15.5 0.1 2.7 2 1 0 2 2 2 2 FMN-dependent dehydrogenase YSIRK_signal PF04650.17 AAS51193.1 - 0.24 11.3 0.7 0.48 10.3 0.7 1.5 1 0 0 1 1 1 0 YSIRK type signal peptide BING4CT PF08149.11 AAS51194.1 - 3.3e-38 129.3 0.0 5.4e-35 119.1 0.0 3.4 3 0 0 3 3 3 2 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 AAS51194.1 - 2.5e-06 27.7 0.0 4.4 7.7 0.0 4.7 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS51194.1 - 3.9e-05 24.3 0.0 0.018 15.9 0.0 4.5 5 1 0 5 5 5 1 WD domain, G-beta repeat RPN2_C PF18004.1 AAS51195.1 - 1.5e-53 181.0 8.3 2.4e-53 180.3 8.3 1.3 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PC_rep PF01851.22 AAS51195.1 - 1.2e-38 129.6 24.8 1.3e-05 25.4 0.4 9.2 9 0 0 9 9 9 7 Proteasome/cyclosome repeat HEAT_2 PF13646.6 AAS51195.1 - 8.3e-20 71.0 1.0 1.9e-14 53.8 0.1 5.2 3 1 2 5 5 5 3 HEAT repeats HEAT PF02985.22 AAS51195.1 - 7.2e-10 38.3 0.3 0.63 10.5 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.6 AAS51195.1 - 7.4e-09 35.9 3.7 0.49 11.0 0.1 5.9 5 1 1 6 6 6 3 HEAT-like repeat Cnd1 PF12717.7 AAS51195.1 - 0.0065 16.5 4.9 2.4 8.2 0.0 4.2 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 RICTOR_V PF14668.6 AAS51195.1 - 0.044 14.0 0.0 0.46 10.8 0.0 2.8 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 2-Hacid_dh_C PF02826.19 AAS51196.1 - 3e-56 189.6 0.0 4.7e-56 189.0 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AAS51196.1 - 3.9e-37 126.9 0.0 5.2e-37 126.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AAS51196.1 - 4.9e-06 26.8 0.9 3e-05 24.2 0.3 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 AAS51196.1 - 0.00012 22.2 0.1 0.00023 21.3 0.1 1.4 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ACT PF01842.25 AAS51196.1 - 0.00028 20.6 0.0 0.00083 19.1 0.0 1.8 1 0 0 1 1 1 1 ACT domain IlvN PF07991.12 AAS51196.1 - 0.085 12.4 0.1 0.18 11.4 0.1 1.5 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain APH PF01636.23 AAS51197.2 - 2.5e-10 40.7 0.0 8.4e-10 39.0 0.0 1.8 1 1 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AAS51197.2 - 0.012 15.2 0.1 0.051 13.2 0.0 2.1 2 0 0 2 2 2 0 Choline/ethanolamine kinase RIO1 PF01163.22 AAS51197.2 - 0.026 14.1 0.1 0.15 11.7 0.0 2.2 1 1 1 2 2 2 0 RIO1 family Kdo PF06293.14 AAS51197.2 - 0.072 12.4 0.0 12 5.1 0.0 2.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family U1snRNP70_N PF12220.8 AAS51197.2 - 0.32 11.7 2.6 29 5.4 0.1 3.5 3 1 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal HORMA PF02301.18 AAS51199.1 - 2.2e-61 207.2 0.1 4.4e-61 206.2 0.1 1.5 1 0 0 1 1 1 1 HORMA domain PHD PF00628.29 AAS51199.1 - 0.32 10.9 10.9 0.67 9.9 10.9 1.6 1 0 0 1 1 1 0 PHD-finger PHD_2 PF13831.6 AAS51199.1 - 3 7.5 8.5 6.6 6.4 8.5 1.6 1 0 0 1 1 1 0 PHD-finger Peptidase_M24 PF00557.24 AAS51200.2 - 3.7e-52 177.0 0.0 5.7e-52 176.4 0.0 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AAS51200.2 - 2.4e-36 124.1 0.0 4.9e-36 123.2 0.0 1.5 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NAD_binding_8 PF13450.6 AAS51200.2 - 0.0057 16.9 0.0 1.5 9.1 0.0 2.8 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain PCI PF01399.27 AAS51201.1 - 3.2e-05 24.4 0.1 0.00013 22.4 0.0 2.1 3 0 0 3 3 3 1 PCI domain PPR_2 PF13041.6 AAS51202.1 - 1.9e-11 44.0 0.4 2.6e-09 37.1 0.0 3.9 4 1 1 5 5 5 1 PPR repeat family PPR_long PF17177.4 AAS51202.1 - 0.00049 19.5 0.0 0.0013 18.1 0.0 1.7 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 AAS51202.1 - 0.022 15.0 1.7 6 7.4 0.1 3.3 3 0 0 3 3 3 0 PPR repeat MAM33 PF02330.16 AAS51203.2 - 5.4e-50 170.3 8.2 6.4e-50 170.0 8.2 1.1 1 0 0 1 1 1 1 Mitochondrial glycoprotein tRNA-synt_His PF13393.6 AAS51203.2 - 0.02 14.2 0.0 0.03 13.6 0.0 1.3 1 0 0 1 1 1 0 Histidyl-tRNA synthetase FTCD_C PF04961.12 AAS51203.2 - 0.088 12.6 1.3 0.13 12.0 1.3 1.4 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase DUF4252 PF14060.6 AAS51203.2 - 0.18 11.7 4.9 0.27 11.1 1.2 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4252) Pmp3 PF01679.17 AAS51204.1 - 3.2e-17 62.5 7.4 4.9e-17 61.9 7.4 1.3 1 0 0 1 1 1 1 Proteolipid membrane potential modulator UPF0029 PF01205.19 AAS51206.1 - 8.6e-30 103.2 0.0 1.1e-29 102.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 Hva1_TUDOR PF11160.8 AAS51206.1 - 0.017 15.2 0.9 0.039 14.1 0.1 2.0 2 0 0 2 2 2 0 Hypervirulence associated proteins TUDOR domain VitD-bind_III PF09164.10 AAS51206.1 - 0.13 12.2 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Vitamin D binding protein, domain III FAD-oxidase_C PF02913.19 AAS51207.1 - 2.7e-55 187.7 0.0 3.6e-55 187.3 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AAS51207.1 - 7.2e-37 126.2 0.2 1.2e-36 125.5 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain RNA_pol_I_TF PF04090.12 AAS51208.2 - 2.1e-73 246.1 1.2 3.1e-73 245.5 1.2 1.2 1 0 0 1 1 1 1 RNA polymerase I specific initiation factor zf-RING_2 PF13639.6 AAS51209.2 - 2.7e-11 43.6 5.6 5.5e-11 42.6 5.6 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AAS51209.2 - 6.1e-08 32.8 5.0 1.2e-07 31.9 5.0 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 AAS51209.2 - 1.7e-07 31.0 3.4 3.4e-07 30.0 3.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS51209.2 - 1.3e-06 28.2 5.8 2.7e-06 27.1 5.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS51209.2 - 4.8e-06 26.3 2.5 9.6e-06 25.4 2.5 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 AAS51209.2 - 1.2e-05 25.0 9.1 3.1e-05 23.7 9.1 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS51209.2 - 1.5e-05 24.8 3.1 2.8e-05 24.0 3.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AAS51209.2 - 0.0005 20.0 4.1 0.0012 18.8 4.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 AAS51209.2 - 0.0016 18.4 0.8 0.004 17.2 0.8 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 AAS51209.2 - 0.0032 17.0 0.4 0.0083 15.7 0.4 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 AAS51209.2 - 0.0058 16.4 1.2 0.0058 16.4 1.2 2.5 2 1 0 2 2 2 1 RING-like zinc finger Uds1 PF15456.6 AAS51209.2 - 0.021 15.0 0.6 0.041 14.0 0.6 1.4 1 0 0 1 1 1 0 Up-regulated During Septation FANCL_C PF11793.8 AAS51209.2 - 0.14 12.4 2.2 0.46 10.7 2.2 1.9 1 1 0 1 1 1 0 FANCL C-terminal domain CTU2 PF10288.9 AAS51209.2 - 0.65 10.3 2.5 6.8 7.0 2.5 2.4 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C3HC4_4 PF15227.6 AAS51209.2 - 1.1 9.4 4.4 0.62 10.3 1.5 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING RINGv PF12906.7 AAS51209.2 - 1.3 9.2 3.7 3.8 7.7 3.7 1.9 1 1 0 1 1 1 0 RING-variant domain zf-RING_4 PF14570.6 AAS51209.2 - 3.3 7.6 5.4 8.4 6.3 4.6 2.1 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain OPA3 PF07047.12 AAS51210.1 - 8e-44 148.4 0.7 8.9e-44 148.3 0.7 1.0 1 0 0 1 1 1 1 Optic atrophy 3 protein (OPA3) NYD-SP28_assoc PF14775.6 AAS51210.1 - 0.038 14.1 0.8 0.038 14.1 0.8 2.1 2 1 0 2 2 2 0 Sperm tail C-terminal domain Phage_GP20 PF06810.11 AAS51210.1 - 0.051 13.4 0.8 0.051 13.4 0.8 1.5 2 0 0 2 2 2 0 Phage minor structural protein GP20 BST2 PF16716.5 AAS51210.1 - 0.11 13.1 3.8 0.51 11.0 0.6 2.2 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Histone PF00125.24 AAS51211.1 - 8.1e-17 61.8 0.0 1e-16 61.5 0.0 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 AAS51211.1 - 6.1e-14 51.5 0.4 1.1e-13 50.6 0.4 1.5 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 AAS51211.1 - 4.3e-05 23.7 0.0 5.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF4 PF05236.14 AAS51212.1 - 1.2e-54 186.0 7.2 3.4e-54 184.5 7.2 1.8 1 1 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family RTC PF01137.21 AAS51213.1 - 1.3e-44 152.0 0.0 1.7e-44 151.7 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 AAS51213.1 - 1.9e-31 108.6 0.0 3.4e-31 107.8 0.0 1.4 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PX PF00787.24 AAS51214.2 - 6.5e-20 71.2 0.0 1.8e-19 69.8 0.0 1.8 1 0 0 1 1 1 1 PX domain CyRPA PF18638.1 AAS51214.2 - 0.024 13.8 1.0 0.039 13.1 1.0 1.3 1 0 0 1 1 1 0 Cysteine-Rich Protective Antigen 6 bladed domain NleF_casp_inhib PF16809.5 AAS51214.2 - 0.038 13.9 3.7 6.9 6.6 0.0 3.3 2 1 1 3 3 3 0 NleF caspase inhibitor DUF1704 PF08014.11 AAS51214.2 - 0.046 12.7 0.1 0.075 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1704) FlxA PF14282.6 AAS51214.2 - 2.4 8.2 5.3 31 4.6 0.1 3.0 3 0 0 3 3 3 0 FlxA-like protein Fez1 PF06818.15 AAS51214.2 - 4 7.8 8.4 1.4 9.3 5.7 1.6 2 0 0 2 2 2 0 Fez1 MMM1 PF10296.9 AAS51215.2 - 9e-10 38.1 0.1 1.3e-09 37.6 0.1 1.2 1 0 0 1 1 1 1 Maintenance of mitochondrial morphology protein 1 Polyketide_cyc PF03364.20 AAS51216.1 - 4.8e-15 55.9 0.0 6.1e-15 55.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport SAP PF02037.27 AAS51217.1 - 1.6e-10 40.4 0.0 2.7e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 SAP domain CHCH PF06747.13 AAS51218.2 - 1.2e-05 25.3 4.2 1.8e-05 24.8 4.2 1.2 1 0 0 1 1 1 1 CHCH domain DUF2076 PF09849.9 AAS51218.2 - 0.00015 21.9 7.7 0.00016 21.8 7.7 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2076) CX9C PF16860.5 AAS51218.2 - 0.0015 18.5 3.8 0.0024 17.9 3.8 1.2 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Topoisom_I PF01028.20 AAS51220.2 - 2.7e-98 327.9 0.8 2.7e-98 327.9 0.8 3.4 5 0 0 5 5 5 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 AAS51220.2 - 3.4e-97 324.1 0.5 3.4e-97 324.1 0.5 2.5 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 AAS51220.2 - 8.6e-33 112.1 1.3 2.6e-32 110.6 1.3 1.9 1 0 0 1 1 1 1 C-terminal topoisomerase domain DASH_Hsk3 PF08227.11 AAS51220.2 - 0.1 13.0 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like Pkinase PF00069.25 AAS51222.2 - 1.5e-75 254.0 0.0 2.8e-75 253.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51222.2 - 5.6e-39 134.0 0.0 8.8e-39 133.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase POLO_box PF00659.18 AAS51222.2 - 2.7e-27 94.7 0.0 1.1e-13 51.1 0.0 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 AAS51222.2 - 9.3e-11 41.6 0.0 1.2e-09 37.9 0.0 2.3 1 1 1 2 2 2 1 Kinase-like Kdo PF06293.14 AAS51222.2 - 0.0013 18.1 0.1 0.0052 16.2 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family SH3_3 PF08239.11 AAS51222.2 - 0.033 14.5 0.1 0.06 13.6 0.1 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain DUF5386 PF17360.2 AAS51222.2 - 0.04 13.8 0.1 9.5 6.1 0.1 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5386) RNA_pol_L_2 PF13656.6 AAS51223.1 - 2.3e-26 91.4 0.0 3.3e-26 90.9 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AAS51223.1 - 3.3e-09 36.0 0.0 5.4e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thymidylate_kin PF02223.17 AAS51223.1 - 0.062 13.0 0.0 0.076 12.7 0.0 1.1 1 0 0 1 1 1 0 Thymidylate kinase Sin3a_C PF16879.5 AAS51224.1 - 2.4e-76 257.2 5.4 7e-76 255.7 4.2 2.5 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein PAH PF02671.21 AAS51224.1 - 8.7e-49 163.4 10.7 6.3e-18 64.7 0.0 3.8 3 0 0 3 3 3 3 Paired amphipathic helix repeat Sin3_corepress PF08295.12 AAS51224.1 - 1e-42 144.2 0.1 2.3e-42 143.0 0.1 1.7 1 0 0 1 1 1 1 Sin3 family co-repressor PRD PF00874.20 AAS51224.1 - 0.053 13.8 0.4 0.32 11.3 0.2 2.6 1 1 0 1 1 1 0 PRD domain Dna2 PF08696.11 AAS51224.1 - 0.29 10.9 2.4 4 7.2 0.2 3.3 3 0 0 3 3 3 0 DNA replication factor Dna2 DHHC PF01529.20 AAS51225.2 - 2.3e-30 105.4 12.2 2.3e-30 105.4 12.2 1.9 2 0 0 2 2 2 1 DHHC palmitoyltransferase HlyIII PF03006.20 AAS51226.2 - 2e-56 191.3 18.0 2.4e-56 191.0 18.0 1.1 1 0 0 1 1 1 1 Haemolysin-III related DNA_pol_A_exo1 PF01612.20 AAS51227.2 - 5.2e-42 143.5 0.1 1.2e-41 142.4 0.1 1.6 2 0 0 2 2 2 1 3'-5' exonuclease PMC2NT PF08066.12 AAS51227.2 - 1.3e-23 83.4 3.7 4.1e-23 81.9 1.3 2.7 2 0 0 2 2 2 1 PMC2NT (NUC016) domain HRDC PF00570.23 AAS51227.2 - 6.3e-10 38.9 0.0 1.4e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 HRDC domain DUF5085 PF16895.5 AAS51227.2 - 0.015 15.7 0.0 0.029 14.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5085) UPF0561 PF10573.9 AAS51227.2 - 0.049 13.8 0.4 0.34 11.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family UPF0561 Cyclin PF08613.11 AAS51228.1 - 2e-35 122.6 0.4 2e-35 122.6 0.4 2.3 2 1 1 3 3 3 1 Cyclin Cyclin_N PF00134.23 AAS51228.1 - 0.0011 18.7 0.1 0.0022 17.8 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ras PF00071.22 AAS51230.1 - 2.5e-58 196.2 0.2 3e-58 196.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51230.1 - 3.1e-34 117.8 0.1 5.9e-34 116.9 0.1 1.4 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51230.1 - 2.6e-15 56.3 0.0 3e-15 56.1 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS51230.1 - 8.8e-08 31.8 0.1 1.1e-07 31.5 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS51230.1 - 1.6e-06 28.2 0.0 3.5e-06 27.1 0.0 1.6 1 1 1 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS51230.1 - 1.8e-06 27.6 0.2 9.7e-05 22.0 0.2 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AAS51230.1 - 3.4e-05 23.3 0.0 4.6e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AAS51230.1 - 0.00013 21.9 0.1 0.031 14.2 0.0 2.3 1 1 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 AAS51230.1 - 0.0015 18.4 0.2 0.029 14.2 0.0 2.1 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 AAS51230.1 - 0.0031 17.8 0.0 0.0052 17.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 AAS51230.1 - 0.0054 16.3 0.0 0.017 14.7 0.0 1.7 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 AAS51230.1 - 0.0081 16.5 0.0 0.014 15.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 AAS51230.1 - 0.0087 16.0 0.1 0.023 14.6 0.1 1.7 2 0 0 2 2 2 1 NTPase TniB PF05621.11 AAS51230.1 - 0.014 14.8 0.0 0.021 14.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein PduV-EutP PF10662.9 AAS51230.1 - 0.02 14.7 0.4 0.075 12.8 0.1 2.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 AAS51230.1 - 0.02 14.8 0.0 0.047 13.6 0.0 1.6 2 0 0 2 2 2 0 NACHT domain Septin PF00735.18 AAS51230.1 - 0.028 13.7 0.1 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 Septin AAA_7 PF12775.7 AAS51230.1 - 0.029 13.9 0.1 0.044 13.3 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AAS51230.1 - 0.034 13.9 0.1 0.089 12.5 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AAS51230.1 - 0.042 14.0 0.0 0.073 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.6 AAS51230.1 - 0.16 10.8 0.0 0.71 8.6 0.0 1.8 2 0 0 2 2 2 0 AAA-like domain AAA_5 PF07728.14 AAS51230.1 - 0.18 11.8 0.0 0.5 10.4 0.0 1.8 2 1 1 3 3 3 0 AAA domain (dynein-related subfamily) Alg6_Alg8 PF03155.15 AAS51231.1 - 1.8e-145 485.6 27.4 2.5e-145 485.2 27.4 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family SGTA_dimer PF16546.5 AAS51232.1 - 3e-19 68.6 0.0 5.9e-19 67.6 0.0 1.5 1 0 0 1 1 1 1 Homodimerisation domain of SGTA TPR_1 PF00515.28 AAS51232.1 - 9.6e-18 63.2 7.8 2.1e-06 27.3 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 AAS51232.1 - 8.4e-17 59.9 12.0 3.5e-05 23.6 0.2 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 AAS51232.1 - 4.5e-13 48.7 9.8 6.5e-05 22.5 0.3 3.4 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 AAS51232.1 - 1.6e-08 34.1 15.0 0.00034 20.6 1.3 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51232.1 - 6.9e-07 29.6 7.7 0.0067 17.2 0.2 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51232.1 - 1.1e-06 28.8 12.3 0.0058 16.9 0.5 3.3 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 AAS51232.1 - 1.5e-06 27.9 8.7 0.054 13.4 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS51232.1 - 3.1e-06 26.8 8.0 0.21 11.7 0.2 4.2 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 AAS51232.1 - 3.6e-06 27.0 4.1 0.00026 21.2 0.3 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat STI1 PF17830.1 AAS51232.1 - 1.1e-05 25.2 4.7 0.00013 21.8 4.2 2.2 2 0 0 2 2 2 1 STI1 domain TPR_19 PF14559.6 AAS51232.1 - 2.9e-05 24.5 9.0 0.0069 16.9 0.3 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51232.1 - 0.00022 21.8 11.2 0.049 14.3 3.2 2.8 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 AAS51232.1 - 0.0003 20.9 1.8 0.0075 16.4 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 AAS51232.1 - 0.0003 21.2 7.6 0.027 15.1 0.1 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat BTAD PF03704.17 AAS51232.1 - 0.023 15.1 5.9 0.43 11.0 5.7 2.4 1 1 0 1 1 1 0 Bacterial transcriptional activator domain DUF3856 PF12968.7 AAS51232.1 - 0.14 12.2 5.3 10 6.2 4.6 3.2 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 AAS51232.1 - 0.15 12.1 0.1 0.15 12.1 0.1 4.2 4 2 1 5 5 4 0 MIT (microtubule interacting and transport) domain XPC-binding PF09280.11 AAS51232.1 - 0.16 11.7 1.2 0.29 10.9 1.2 1.4 1 0 0 1 1 1 0 XPC-binding domain Fis1_TPR_C PF14853.6 AAS51232.1 - 0.65 10.1 8.6 0.7 10.0 0.2 3.9 2 2 2 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 AAS51232.1 - 1.4 9.2 8.7 2.1 8.6 6.3 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 VPS9 PF02204.18 AAS51233.1 - 1.7e-18 66.7 0.1 6.5e-18 64.9 0.1 2.0 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain Ank_5 PF13857.6 AAS51233.1 - 0.00012 22.3 0.1 0.00072 19.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 AAS51233.1 - 0.00041 20.9 1.3 1.4 9.6 0.0 3.6 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) ResIII PF04851.15 AAS51233.1 - 0.018 15.1 0.3 1.1 9.2 0.0 2.7 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Ank PF00023.30 AAS51233.1 - 0.074 13.5 0.8 5.5 7.6 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat Ank_3 PF13606.6 AAS51233.1 - 0.32 11.7 2.7 58 4.7 0.0 4.7 4 0 0 4 4 4 0 Ankyrin repeat Ribo_biogen_C PF04034.13 AAS51234.1 - 8.5e-53 177.4 0.0 1.2e-52 177.0 0.0 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AAS51234.1 - 5.7e-16 58.0 0.2 9.4e-16 57.3 0.2 1.4 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Remorin_C PF03763.13 AAS51234.1 - 0.0019 18.1 1.3 0.0019 18.1 1.3 1.7 2 0 0 2 2 2 1 Remorin, C-terminal region DNA_ligase_A_M PF01068.21 AAS51235.1 - 9.7e-48 162.5 0.0 1.4e-47 161.9 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase domain BRCT_2 PF16589.5 AAS51235.1 - 3e-18 66.0 0.1 7.2e-08 32.7 0.0 2.7 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_N PF04675.14 AAS51235.1 - 1e-17 65.0 0.0 1.9e-17 64.1 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus RNA_ligase PF09414.10 AAS51235.1 - 2.6e-11 44.1 0.0 5.2e-11 43.1 0.0 1.5 1 0 0 1 1 1 1 RNA ligase BRCT PF00533.26 AAS51235.1 - 2.3e-07 31.1 0.2 0.00018 21.8 0.0 3.1 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C PF04679.15 AAS51235.1 - 4e-07 30.5 0.0 1.3e-06 28.9 0.0 1.9 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region mRNA_cap_enzyme PF01331.19 AAS51235.1 - 0.00018 21.4 1.5 0.22 11.3 0.1 3.3 2 1 0 2 2 2 2 mRNA capping enzyme, catalytic domain RTT107_BRCT_5 PF16770.5 AAS51235.1 - 0.019 14.8 0.0 2.5 8.0 0.0 2.6 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain TIR_3 PF18567.1 AAS51235.1 - 0.071 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain NPR2 PF06218.11 AAS51236.1 - 1.6e-133 445.7 6.1 1.6e-133 445.7 6.1 2.1 2 0 0 2 2 2 2 Nitrogen permease regulator 2 Kinesin PF00225.23 AAS51237.1 - 7.8e-98 327.5 6.4 7.8e-98 327.5 6.4 3.4 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AAS51237.1 - 6.5e-21 74.8 0.1 6.5e-21 74.8 0.1 2.7 2 0 0 2 2 2 1 Microtubule binding Apolipoprotein PF01442.18 AAS51237.1 - 0.00026 20.9 0.2 0.00026 20.9 0.2 3.0 2 1 0 2 2 2 1 Apolipoprotein A1/A4/E domain FliJ PF02050.16 AAS51237.1 - 0.0016 18.7 10.6 0.0016 18.7 10.6 3.6 3 1 0 3 3 3 1 Flagellar FliJ protein Phasin PF05597.11 AAS51237.1 - 0.15 12.0 11.9 3.2 7.8 0.2 4.9 2 2 3 5 5 5 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF3450 PF11932.8 AAS51237.1 - 0.23 10.7 17.1 0.76 9.0 0.7 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HrpB7 PF09486.10 AAS51237.1 - 0.37 11.2 3.2 0.73 10.2 1.2 2.4 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) Laminin_II PF06009.12 AAS51237.1 - 2.2 8.3 28.9 0.019 15.0 8.6 4.3 3 2 1 4 4 4 0 Laminin Domain II Rx_N PF18052.1 AAS51237.1 - 2.6 8.4 14.5 0.49 10.7 3.2 4.1 4 1 0 4 4 4 0 Rx N-terminal domain ZapB PF06005.12 AAS51237.1 - 9.3 6.8 26.8 12 6.4 0.9 4.2 3 1 1 4 4 4 0 Cell division protein ZapB Fcf1 PF04900.12 AAS51238.1 - 4e-33 113.7 1.1 4e-33 113.7 1.1 1.6 2 0 0 2 2 2 1 Fcf1 Peptidase_S8 PF00082.22 AAS51239.1 - 5.5e-31 107.9 9.3 1.1e-30 106.9 9.3 1.4 1 1 0 1 1 1 1 Subtilase family Inhibitor_I9 PF05922.16 AAS51239.1 - 2.5e-07 31.3 0.0 5.6e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Peptidase inhibitor I9 Lyase_1 PF00206.20 AAS51240.2 - 8e-115 383.5 0.0 1e-114 383.1 0.0 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 AAS51240.2 - 1.3e-23 83.2 0.0 2.8e-23 82.1 0.0 1.6 1 0 0 1 1 1 1 Fumarase C C-terminus Mitochondr_Som1 PF11093.8 AAS51241.1 - 1.8e-14 53.5 2.6 7.9e-14 51.4 2.6 1.8 1 1 0 1 1 1 1 Mitochondrial export protein Som1 PGM_PMM_I PF02878.16 AAS51242.1 - 1e-18 67.4 0.0 6.9e-09 35.5 0.0 2.6 2 0 0 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_IV PF00408.20 AAS51242.1 - 8.2e-11 41.9 0.1 2e-10 40.7 0.1 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain PGM_PMM_II PF02879.16 AAS51242.1 - 0.0035 18.0 0.0 0.035 14.7 0.0 2.5 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Kelch_4 PF13418.6 AAS51243.1 - 6.6e-32 109.3 9.4 3e-08 33.6 0.2 6.9 6 2 0 6 6 6 5 Galactose oxidase, central domain Kelch_3 PF13415.6 AAS51243.1 - 1.8e-27 95.0 6.5 9.7e-09 35.3 0.1 5.5 5 0 0 5 5 5 3 Galactose oxidase, central domain DUF4110 PF13422.6 AAS51243.1 - 8.4e-27 93.1 0.4 8.4e-27 93.1 0.4 3.7 3 2 0 3 3 3 1 Domain of unknown function (DUF4110) Kelch_6 PF13964.6 AAS51243.1 - 1.5e-18 66.3 10.9 7.2e-05 22.9 0.2 5.9 4 2 2 6 6 6 5 Kelch motif Kelch_1 PF01344.25 AAS51243.1 - 2.6e-16 58.9 4.4 6.9e-06 25.5 0.1 5.7 5 0 0 5 5 5 5 Kelch motif Kelch_5 PF13854.6 AAS51243.1 - 1.2e-13 50.7 9.7 8.3e-05 22.5 0.1 6.2 6 1 0 6 6 6 4 Kelch motif Kelch_2 PF07646.15 AAS51243.1 - 3.3e-12 45.8 12.7 0.02 14.9 0.1 6.0 6 0 0 6 6 6 4 Kelch motif CAF1C_H4-bd PF12265.8 AAS51244.1 - 5.8e-20 71.3 0.2 5.8e-20 71.3 0.2 2.3 3 0 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AAS51244.1 - 1.3e-18 67.0 1.2 6.7e-05 23.6 0.8 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat Pyocin_S PF06958.12 AAS51244.1 - 0.012 16.2 0.1 0.04 14.5 0.1 1.8 2 0 0 2 2 2 0 S-type Pyocin ANAPC4_WD40 PF12894.7 AAS51244.1 - 0.024 15.0 0.0 18 5.7 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TFIIE-A_C PF11521.8 AAS51244.1 - 0.034 14.4 0.2 0.98 9.8 0.0 3.0 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha AATase PF07247.12 AAS51245.2 - 1e-06 27.6 0.1 0.001 17.7 0.0 2.3 2 1 0 2 2 2 2 Alcohol acetyltransferase DNA_pol_phi PF04931.13 AAS51247.1 - 9.6e-227 754.8 18.0 1.2e-226 754.4 18.0 1.1 1 0 0 1 1 1 1 DNA polymerase phi UME PF08064.13 AAS51247.1 - 0.017 15.0 4.6 0.091 12.7 0.0 3.7 3 0 0 3 3 3 0 UME (NUC010) domain NnrS PF05940.12 AAS51247.1 - 0.13 11.6 0.2 0.2 11.0 0.2 1.2 1 0 0 1 1 1 0 NnrS protein SDA1 PF05285.12 AAS51247.1 - 0.22 10.9 14.2 0.39 10.1 14.2 1.3 1 0 0 1 1 1 0 SDA1 ATP-synt_Eps PF04627.13 AAS51248.1 - 4e-18 65.1 2.0 5.4e-18 64.7 2.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase epsilon chain ABC_membrane PF00664.23 AAS51249.2 - 1.7e-52 178.8 2.4 2.2e-52 178.4 2.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AAS51249.2 - 4.4e-34 117.9 0.0 2.9e-33 115.3 0.0 2.1 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 AAS51249.2 - 0.00032 20.2 0.0 0.015 14.7 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 AAS51249.2 - 0.0011 19.2 0.1 0.018 15.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS51249.2 - 0.0013 19.2 0.9 0.038 14.4 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain IstB_IS21 PF01695.17 AAS51249.2 - 0.0068 16.2 0.2 0.24 11.1 0.0 3.0 3 1 1 4 4 4 1 IstB-like ATP binding protein AAA_5 PF07728.14 AAS51249.2 - 0.0073 16.3 0.0 0.031 14.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 AAS51249.2 - 0.011 15.5 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 AAS51249.2 - 0.012 16.0 0.0 0.14 12.5 0.0 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 AAS51249.2 - 0.02 14.6 0.0 0.042 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 AAS51249.2 - 0.042 13.6 0.0 0.97 9.2 0.0 2.3 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_7 PF12775.7 AAS51249.2 - 0.043 13.3 0.2 0.094 12.2 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Trp_oprn_chp PF09534.10 AAS51249.2 - 0.11 12.3 1.1 0.22 11.3 1.1 1.5 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) RsgA_GTPase PF03193.16 AAS51249.2 - 0.12 12.2 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 AAS51249.2 - 0.14 11.8 0.0 0.35 10.6 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_15 PF13175.6 AAS51249.2 - 0.23 11.1 0.0 0.39 10.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain KAR9 PF08580.10 AAS51250.1 - 2.5e-193 644.4 2.6 3.1e-193 644.1 2.6 1.0 1 0 0 1 1 1 1 Yeast cortical protein KAR9 Baculo_PEP_C PF04513.12 AAS51250.1 - 0.38 10.8 6.2 1.6 8.7 1.0 3.1 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus PI-PLC-X PF00388.19 AAS51251.1 - 1.3e-49 167.5 0.0 5.6e-49 165.5 0.0 2.1 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y PF00387.19 AAS51251.1 - 5.2e-39 133.1 0.2 2.3e-38 131.1 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain EF-hand_1 PF00036.32 AAS51251.1 - 2.5e-06 26.6 0.2 1e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_like PF09279.11 AAS51251.1 - 7.5e-06 26.4 0.5 2e-05 25.0 0.5 1.8 1 0 0 1 1 1 1 Phosphoinositide-specific phospholipase C, efhand-like EF-hand_7 PF13499.6 AAS51251.1 - 0.00019 21.8 0.4 0.00085 19.7 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 AAS51251.1 - 0.0011 18.8 0.3 0.074 12.9 0.1 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AAS51251.1 - 0.0015 18.3 1.6 0.0055 16.5 0.0 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_10 PF14788.6 AAS51251.1 - 0.0035 17.2 3.9 0.0047 16.8 0.2 2.7 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 AAS51251.1 - 0.0056 16.6 0.1 0.014 15.4 0.1 1.7 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand C2 PF00168.30 AAS51251.1 - 0.028 14.7 0.0 0.095 13.0 0.0 1.9 2 0 0 2 2 2 0 C2 domain EF-hand_5 PF13202.6 AAS51251.1 - 0.048 13.2 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 EF hand Gti1_Pac2 PF09729.9 AAS51252.1 - 0.062 13.4 0.2 0.062 13.4 0.2 1.9 1 1 1 2 2 2 0 Gti1/Pac2 family RrnaAD PF00398.20 AAS51253.1 - 2.3e-71 240.0 0.0 2.9e-71 239.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 AAS51253.1 - 1.4e-07 32.1 0.0 6.7e-07 29.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS51253.1 - 2.6e-05 24.8 0.0 8.7e-05 23.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AAS51253.1 - 6.5e-05 22.8 0.0 0.00012 21.9 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AAS51253.1 - 0.0017 17.7 0.0 0.0052 16.1 0.0 1.6 2 0 0 2 2 2 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 AAS51253.1 - 0.0023 18.6 0.0 0.014 16.1 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 AAS51253.1 - 0.0042 16.4 0.1 0.058 12.7 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Met_10 PF02475.16 AAS51253.1 - 0.0049 16.6 0.0 0.0086 15.8 0.0 1.4 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_2 PF00891.18 AAS51253.1 - 0.0091 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 AAS51253.1 - 0.017 14.9 0.0 0.035 13.9 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain MTS PF05175.14 AAS51253.1 - 0.026 14.1 0.0 0.051 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_28 PF02636.17 AAS51253.1 - 0.046 13.3 0.0 0.11 12.1 0.0 1.7 1 1 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase PRMT5 PF05185.16 AAS51253.1 - 0.08 12.8 0.1 0.74 9.6 0.0 2.1 2 0 0 2 2 2 0 PRMT5 arginine-N-methyltransferase DUF917 PF06032.12 AAS51254.2 - 6.7e-105 350.8 0.0 1.1e-104 350.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF917) Hydant_A_N PF05378.13 AAS51254.2 - 4.3e-34 117.8 1.4 3.2e-32 111.7 0.0 3.3 4 0 0 4 4 4 1 Hydantoinase/oxoprolinase N-terminal region Hydantoinase_A PF01968.18 AAS51254.2 - 1.6e-24 86.6 2.0 4e-21 75.5 2.3 3.5 3 1 0 3 3 3 2 Hydantoinase/oxoprolinase MutL PF13941.6 AAS51254.2 - 0.014 14.0 0.1 0.36 9.4 0.0 2.3 2 0 0 2 2 2 0 MutL protein Zn_clus PF00172.18 AAS51255.1 - 1.8e-09 37.6 11.3 3.1e-09 36.8 11.3 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 AAS51255.1 - 9.6e-09 34.5 0.6 1.8e-08 33.6 0.6 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Fasciclin PF02469.22 AAS51256.2 - 2.5e-11 43.9 0.0 0.00014 22.0 0.0 4.4 4 1 0 4 4 4 3 Fasciclin domain Aa_trans PF01490.18 AAS51257.1 - 2.9e-78 263.4 17.1 3.5e-78 263.1 17.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Mpp10 PF04006.12 AAS51258.1 - 4.8e-147 491.0 51.1 5.8e-147 490.8 51.1 1.0 1 0 0 1 1 1 1 Mpp10 protein Pet20 PF08692.10 AAS51258.1 - 9.6 6.9 6.4 63 4.3 0.0 3.1 2 1 0 2 2 2 0 Mitochondrial protein Pet20 NOC3p PF07540.11 AAS51259.1 - 1.2e-29 102.6 0.7 1.2e-29 102.6 0.7 3.3 2 1 0 2 2 2 1 Nucleolar complex-associated protein CBF PF03914.17 AAS51259.1 - 2.8e-25 89.3 0.7 2.8e-25 89.3 0.7 2.7 3 0 0 3 3 3 1 CBF/Mak21 family Dynamin_N PF00350.23 AAS51259.1 - 0.0001 22.4 0.8 0.0001 22.4 0.8 2.6 2 0 0 2 2 2 1 Dynamin family Gluconate_2-dh3 PF13618.6 AAS51259.1 - 0.1 12.8 0.1 0.48 10.7 0.1 2.1 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 Focal_AT PF03623.13 AAS51259.1 - 0.25 11.4 6.9 0.25 11.3 3.9 2.5 3 0 0 3 3 3 0 Focal adhesion targeting region RasGAP PF00616.19 AAS51259.1 - 5.5 6.6 12.7 0.53 9.9 4.4 2.7 2 0 0 2 2 2 0 GTPase-activator protein for Ras-like GTPase DUF5572 PF17733.1 AAS51260.1 - 5.2e-13 48.6 0.0 8.3e-13 48.0 0.0 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5572) Mannosyl_trans PF05007.13 AAS51261.1 - 1.2e-79 267.8 25.5 1.2e-79 267.8 25.5 1.6 2 0 0 2 2 2 1 Mannosyltransferase (PIG-M) PIG-U PF06728.13 AAS51261.1 - 4.3e-12 45.8 7.2 4.3e-12 45.8 7.2 2.1 2 0 0 2 2 2 1 GPI transamidase subunit PIG-U GT87 PF09594.10 AAS51261.1 - 3.5e-07 30.2 17.9 3.5e-07 30.2 17.9 1.7 1 1 0 1 1 1 1 Glycosyltransferase family 87 RNase_PH PF01138.21 AAS51262.1 - 1.2e-27 97.0 0.0 1.6e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AAS51262.1 - 0.00013 22.0 0.2 0.00086 19.3 0.0 2.2 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 Nramp PF01566.18 AAS51264.1 - 8.9e-92 307.8 12.4 1.5e-91 307.1 12.4 1.3 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein HSP70 PF00012.20 AAS51265.1 - 7e-263 873.3 11.5 8e-263 873.1 11.5 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS51265.1 - 5.8e-19 68.1 1.4 8.9e-18 64.2 0.4 2.1 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 AAS51265.1 - 0.00067 19.0 1.8 0.23 10.7 0.1 3.1 2 1 1 3 3 3 2 Hydantoinase/oxoprolinase FtsA PF14450.6 AAS51265.1 - 0.0024 18.2 2.2 2.1 8.8 0.0 3.0 3 2 0 3 3 3 2 Cell division protein FtsA BcrAD_BadFG PF01869.20 AAS51265.1 - 0.0025 17.4 0.2 0.028 13.9 0.2 2.3 1 1 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family Radial_spoke_3 PF06098.11 AAS51265.1 - 0.0075 15.6 3.1 0.016 14.5 3.1 1.5 1 0 0 1 1 1 1 Radial spoke protein 3 FGGY_C PF02782.16 AAS51265.1 - 0.064 13.0 0.0 0.39 10.4 0.0 2.2 2 0 0 2 2 2 0 FGGY family of carbohydrate kinases, C-terminal domain Ntox15 PF15604.6 AAS51265.1 - 0.22 11.6 3.5 0.61 10.2 3.5 1.7 1 0 0 1 1 1 0 Novel toxin 15 Sec34 PF04136.15 AAS51265.1 - 0.4 10.5 2.5 0.36 10.7 0.9 1.7 2 0 0 2 2 2 0 Sec34-like family FHA PF00498.26 AAS51266.1 - 7.3e-11 42.3 0.0 1.2e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 FHA domain DEAD PF00270.29 AAS51267.2 - 2.8e-48 164.0 0.0 7.8e-48 162.5 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51267.2 - 1.8e-24 86.2 0.0 6.1e-24 84.5 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AAS51267.2 - 1.5e-21 76.4 0.0 3.6e-21 75.1 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AAS51267.2 - 6.5e-07 29.5 0.0 2e-06 27.9 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 AAS51267.2 - 0.021 15.0 1.3 0.028 14.6 0.0 1.8 2 0 0 2 2 2 0 Helicase C-terminal domain CMS1 PF14617.6 AAS51267.2 - 0.21 10.9 0.0 0.21 10.9 0.0 3.2 4 0 0 4 4 4 0 U3-containing 90S pre-ribosomal complex subunit Cyclin_N PF00134.23 AAS51268.2 - 3.8e-14 52.5 9.1 1.2e-13 50.9 4.9 2.3 2 0 0 2 2 2 1 Cyclin, N-terminal domain TFIIB PF00382.19 AAS51268.2 - 0.067 13.2 0.1 0.27 11.3 0.0 2.0 2 0 0 2 2 2 0 Transcription factor TFIIB repeat MRP-63 PF14978.6 AAS51268.2 - 0.083 13.5 0.6 0.35 11.5 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial ribosome protein 63 PPTA PF01239.22 AAS51269.1 - 3.7e-37 125.0 12.4 4.8e-10 38.8 0.0 5.6 5 0 0 5 5 5 5 Protein prenyltransferase alpha subunit repeat HORMA PF02301.18 AAS51270.1 - 1.8e-25 89.8 0.3 3.6e-25 88.8 0.3 1.4 1 1 0 1 1 1 1 HORMA domain ATG13 PF10033.9 AAS51270.1 - 0.0013 18.5 0.0 0.0024 17.6 0.0 1.4 1 0 0 1 1 1 1 Autophagy-related protein 13 DUF3440 PF11922.8 AAS51270.1 - 0.13 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3440) Vps53_N PF04100.12 AAS51271.2 - 1.3e-81 274.6 11.5 1.9e-81 274.0 11.5 1.3 1 0 0 1 1 1 1 Vps53-like, N-terminal VPS53_C PF16854.5 AAS51271.2 - 1.2e-71 240.8 0.1 3.9e-71 239.1 0.1 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 53 C-terminus DUF4200 PF13863.6 AAS51271.2 - 0.25 11.8 2.1 0.76 10.2 1.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DivIVA PF05103.13 AAS51271.2 - 1.2 9.3 5.7 0.26 11.4 0.5 2.5 3 0 0 3 3 3 0 DivIVA protein LOH1CR12 PF10158.9 AAS51271.2 - 1.6 8.7 4.3 0.79 9.7 0.3 2.6 2 1 1 3 3 3 0 Tumour suppressor protein Cpn60_TCP1 PF00118.24 AAS51272.2 - 9.4e-151 502.8 6.8 1.1e-150 502.6 6.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EAL PF00563.20 AAS51272.2 - 0.0033 17.0 0.0 0.031 13.8 0.0 2.1 2 0 0 2 2 2 1 EAL domain PUF PF00806.19 AAS51273.2 - 3.7e-27 92.4 7.7 0.00026 20.5 0.0 8.8 9 0 0 9 9 9 7 Pumilio-family RNA binding repeat DUF3294 PF07957.11 AAS51274.1 - 4.8e-94 314.0 1.1 5.3e-94 313.9 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3294) SKA1 PF07160.12 AAS51274.1 - 0.085 12.7 1.6 3.4 7.5 0.5 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 CLZ PF16526.5 AAS51274.1 - 0.72 10.3 0.1 0.72 10.3 0.1 3.0 3 2 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels LTV PF04180.14 AAS51275.1 - 6e-105 352.1 24.9 6.9e-105 351.9 24.9 1.0 1 0 0 1 1 1 1 Low temperature viability protein RNA_pol_Rbc25 PF08292.12 AAS51276.1 - 1.1e-51 174.5 0.5 1.4e-51 174.1 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 AAS51276.1 - 1.1e-19 70.6 0.0 2.3e-19 69.5 0.0 1.6 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AAS51276.1 - 1.4e-05 25.3 0.0 2.8e-05 24.3 0.0 1.5 1 1 0 1 1 1 1 S1 RNA binding domain AAA PF00004.29 AAS51277.1 - 3e-40 137.7 0.1 6.6e-40 136.6 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS51277.1 - 4.5e-07 29.6 0.0 1.2e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 AAS51277.1 - 6.4e-05 23.0 0.0 0.00022 21.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AAS51277.1 - 6.6e-05 23.2 0.0 0.0029 17.9 0.0 2.6 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 AAS51277.1 - 0.00018 21.9 0.1 0.0037 17.7 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 AAS51277.1 - 0.0004 20.5 0.0 0.00084 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AAS51277.1 - 0.00086 18.5 0.0 0.0016 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AAS51277.1 - 0.0051 16.6 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase_2 PF01637.18 AAS51277.1 - 0.0094 15.9 0.7 5.6 6.8 0.0 3.1 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_28 PF13521.6 AAS51277.1 - 0.011 15.9 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AAS51277.1 - 0.018 15.2 0.0 0.058 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AAS51277.1 - 0.031 14.8 0.0 0.082 13.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AAS51277.1 - 0.035 13.8 0.1 0.092 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 AAS51277.1 - 0.039 14.4 0.0 0.089 13.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 AAS51277.1 - 0.039 13.5 0.0 0.094 12.2 0.0 1.6 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AAS51277.1 - 0.046 13.1 0.1 0.13 11.6 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AAS51277.1 - 0.051 13.4 0.0 0.095 12.6 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 AAS51277.1 - 0.059 12.6 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain XhlA PF10779.9 AAS51277.1 - 0.088 13.0 0.7 0.34 11.1 0.8 1.9 2 0 0 2 2 2 0 Haemolysin XhlA IstB_IS21 PF01695.17 AAS51277.1 - 0.094 12.4 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein CaATP_NAI PF12515.8 AAS51277.1 - 0.16 11.6 0.0 0.55 9.9 0.0 1.9 1 0 0 1 1 1 0 Ca2+-ATPase N terminal autoinhibitory domain Aa_trans PF01490.18 AAS51278.2 - 4.2e-85 285.9 30.1 5e-85 285.7 30.1 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein FAD_binding_2 PF00890.24 AAS51279.2 - 3.8e-120 401.8 4.3 4.9e-120 401.4 4.3 1.1 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AAS51279.2 - 1.1e-44 151.5 0.3 1.6e-44 150.9 0.3 1.3 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term GIDA PF01134.22 AAS51279.2 - 1.3e-05 24.5 2.5 0.0031 16.7 2.3 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AAS51279.2 - 2.7e-05 23.6 0.5 6.6e-05 22.3 0.3 1.8 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS51279.2 - 5.1e-05 22.6 0.1 0.01 15.1 0.1 2.9 3 0 0 3 3 3 1 Thi4 family FAD_binding_3 PF01494.19 AAS51279.2 - 0.003 16.8 0.2 0.008 15.5 0.2 1.7 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 AAS51279.2 - 0.056 13.0 4.5 0.2 11.2 4.6 1.8 1 1 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 AAS51279.2 - 0.14 10.8 2.0 0.25 10.0 0.9 2.0 3 0 0 3 3 3 0 HI0933-like protein FAD_oxidored PF12831.7 AAS51279.2 - 0.19 11.0 2.0 3.5 6.9 1.8 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Asparaginase_C PF17763.1 AAS51279.2 - 0.2 11.9 0.4 4.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain Metallophos PF00149.28 AAS51280.1 - 1.2e-06 29.1 0.0 2e-06 28.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase DBR1 PF05011.13 AAS51280.1 - 7.9e-05 23.1 0.0 0.00014 22.3 0.0 1.4 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain NAD_binding_1 PF00175.21 AAS51281.1 - 7.4e-31 107.0 0.0 1.3e-30 106.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AAS51281.1 - 2.5e-26 91.9 0.0 5e-26 91.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AAS51281.1 - 1.1e-05 25.6 0.0 0.00046 20.3 0.0 2.3 1 1 0 2 2 2 1 Ferric reductase NAD binding domain Carb_kinase PF01256.17 AAS51282.2 - 2.7e-58 197.3 0.2 7.4e-58 195.9 0.2 1.7 1 1 0 1 1 1 1 Carbohydrate kinase Phos_pyr_kin PF08543.12 AAS51282.2 - 1.5e-06 27.8 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase His_Phos_1 PF00300.22 AAS51283.2 - 1.9e-35 122.3 0.0 5.5e-28 98.0 0.1 2.0 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) OprB PF04966.12 AAS51283.2 - 0.041 13.3 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Carbohydrate-selective porin, OprB family RabGAP-TBC PF00566.18 AAS51284.1 - 1.1e-21 77.6 0.7 1.5e-21 77.0 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LRR_4 PF12799.7 AAS51286.2 - 0.041 14.3 6.7 2.7 8.6 0.1 4.6 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AAS51286.2 - 0.36 11.5 3.8 4.3 8.3 0.1 4.8 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 AAS51286.2 - 1.6 9.0 4.0 55 4.2 0.0 4.3 5 0 0 5 5 5 0 Leucine Rich repeat Nsp1_C PF05064.13 AAS51287.1 - 3.1e-41 139.8 4.3 3.1e-41 139.8 4.3 2.1 1 1 1 2 2 2 1 Nsp1-like C-terminal region Baculo_p24 PF05073.12 AAS51287.1 - 0.037 13.8 4.7 0.061 13.1 4.7 1.4 1 0 0 1 1 1 0 Baculovirus P24 capsid protein DNA_primase_lrg PF04104.14 AAS51287.1 - 0.096 12.1 1.6 0.16 11.4 1.2 1.5 1 1 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Caudo_TAP PF02413.17 AAS51287.1 - 0.13 12.4 4.0 0.2 11.8 2.7 2.0 2 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK APG6_N PF17675.1 AAS51287.1 - 0.21 12.1 9.7 0.35 11.4 9.7 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Rsd_AlgQ PF04353.13 AAS51287.1 - 0.34 10.8 6.0 0.083 12.8 1.0 2.2 1 1 2 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ RED_C PF07807.11 AAS51287.1 - 0.71 10.4 11.0 13 6.3 0.0 5.7 6 1 1 7 7 7 0 RED-like protein C-terminal region SHIPPO-rpt PF07004.12 AAS51287.1 - 0.97 10.5 53.4 35 5.6 0.5 13.2 9 3 2 11 11 11 0 Sperm-tail PG-rich repeat Lipoprotein_20 PF13942.6 AAS51287.1 - 6.1 6.7 7.5 7.4 6.5 0.6 2.2 2 0 0 2 2 2 0 YfhG lipoprotein DUF1664 PF07889.12 AAS51287.1 - 8.9 6.4 8.2 9.3 6.3 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Nup192 PF11894.8 AAS51288.2 - 0 1710.8 57.4 0 1710.6 57.4 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 SRPRB PF09439.10 AAS51289.1 - 1.2e-72 243.1 0.0 1.6e-72 242.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AAS51289.1 - 7.1e-08 32.2 0.1 5.7e-07 29.3 0.1 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 AAS51289.1 - 1.5e-07 31.1 0.0 2e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AAS51289.1 - 3.7e-07 30.2 0.0 6.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AAS51289.1 - 3.6e-06 26.5 0.0 5.3e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_23 PF13476.6 AAS51289.1 - 0.00016 22.3 1.3 0.00023 21.7 1.3 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 AAS51289.1 - 0.0016 18.3 0.8 0.0085 16.0 0.3 2.1 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 AAS51289.1 - 0.0041 17.3 0.0 0.0072 16.5 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 AAS51289.1 - 0.0068 16.9 0.2 0.012 16.1 0.2 1.5 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 AAS51289.1 - 0.0091 16.4 0.1 0.015 15.7 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain cobW PF02492.19 AAS51289.1 - 0.01 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain PsaM PF07465.13 AAS51289.1 - 0.019 14.6 1.9 0.034 13.9 1.9 1.4 1 0 0 1 1 1 0 Photosystem I protein M (PsaM) AAA_21 PF13304.6 AAS51289.1 - 0.022 14.6 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 AAS51289.1 - 0.024 14.9 0.0 0.082 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain FeoB_N PF02421.18 AAS51289.1 - 0.03 13.9 0.0 0.085 12.4 0.0 1.8 1 1 0 1 1 1 0 Ferrous iron transport protein B Ras PF00071.22 AAS51289.1 - 0.042 13.5 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Ras family ATP_bind_1 PF03029.17 AAS51289.1 - 0.068 12.9 0.4 8.5 6.1 0.0 2.2 1 1 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 AAS51289.1 - 0.073 12.8 0.9 0.14 11.9 0.9 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 AAS51289.1 - 0.092 11.8 0.5 0.17 10.9 0.5 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PduV-EutP PF10662.9 AAS51289.1 - 0.1 12.4 0.0 2.3 7.9 0.0 2.7 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Rsm22 PF09243.10 AAS51290.1 - 5.1e-35 121.1 1.0 6.8e-13 48.5 0.1 4.3 3 1 0 3 3 3 3 Mitochondrial small ribosomal subunit Rsm22 Methyltransf_23 PF13489.6 AAS51290.1 - 2.5e-05 24.2 0.0 6.3e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain DUF1654 PF07867.11 AAS51290.1 - 0.047 13.4 0.2 0.17 11.7 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) Ribosomal_S27e PF01667.17 AAS51291.2 - 3.1e-30 103.7 2.8 4e-30 103.3 2.8 1.2 1 0 0 1 1 1 1 Ribosomal protein S27 IBR PF01485.21 AAS51291.2 - 0.005 17.0 0.9 0.0064 16.7 0.9 1.2 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TF_Zn_Ribbon PF08271.12 AAS51291.2 - 0.023 14.2 4.2 0.035 13.6 4.2 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 AAS51291.2 - 3.2 7.9 6.4 19 5.4 0.2 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Ras PF00071.22 AAS51292.1 - 5.4e-20 71.6 0.0 9.5e-17 61.1 0.0 2.1 2 0 0 2 2 2 2 Ras family RsgA_GTPase PF03193.16 AAS51292.1 - 0.00018 21.4 0.0 0.069 13.1 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AAS51292.1 - 0.0004 20.0 0.0 0.0038 16.8 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Roc PF08477.13 AAS51292.1 - 0.00066 19.9 0.0 0.12 12.6 0.0 2.2 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 AAS51292.1 - 0.0035 17.5 0.0 0.0086 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AAS51292.1 - 0.045 13.8 0.0 0.21 11.6 0.0 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS51292.1 - 0.079 13.3 0.1 0.18 12.2 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain F-box-like PF12937.7 AAS51293.1 - 0.00022 21.0 0.0 0.00057 19.7 0.0 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS51293.1 - 0.0049 16.7 0.0 0.017 15.0 0.0 1.9 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 AAS51293.1 - 0.036 14.4 0.0 0.74 10.2 0.0 2.4 2 0 0 2 2 2 0 PRANC domain LRR_4 PF12799.7 AAS51293.1 - 0.044 14.2 3.3 4.9 7.7 0.0 4.4 5 1 1 6 6 6 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AAS51293.1 - 1.3 8.8 3.6 28 4.6 0.0 4.2 6 0 0 6 6 6 0 Leucine rich repeat Myosin_head PF00063.21 AAS51294.2 - 3.4e-263 874.9 12.2 3.4e-263 874.9 12.2 3.6 4 0 0 4 4 4 1 Myosin head (motor domain) Myosin_N PF02736.19 AAS51294.2 - 0.001 18.8 0.9 0.0028 17.4 0.9 1.8 1 1 0 1 1 1 1 Myosin N-terminal SH3-like domain TsaE PF02367.17 AAS51294.2 - 0.043 13.8 0.0 0.71 9.9 0.0 3.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2293 PF10056.9 AAS51294.2 - 0.045 14.0 2.7 0.32 11.3 0.7 2.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2293) AAA_16 PF13191.6 AAS51294.2 - 0.077 13.4 0.0 0.077 13.4 0.0 3.7 3 2 0 3 3 3 0 AAA ATPase domain AAA_22 PF13401.6 AAS51294.2 - 0.25 11.6 0.0 0.25 11.6 0.0 4.7 4 0 0 4 4 4 0 AAA domain Peptidase_M16_C PF05193.21 AAS51295.1 - 2.7e-45 154.6 0.0 4e-44 150.8 0.0 2.1 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AAS51295.1 - 7.6e-33 113.6 0.9 1.6e-32 112.6 0.3 1.8 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) GHMP_kinases_N PF00288.26 AAS51296.2 - 3.1e-09 36.9 0.1 6.1e-09 36.0 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AAS51296.2 - 0.0029 17.9 0.0 0.0071 16.7 0.0 1.7 1 0 0 1 1 1 1 GHMP kinases C terminal ATP-synt_C PF00137.21 AAS51297.1 - 1.4e-24 86.2 39.0 6.4e-16 58.4 13.1 3.0 3 0 0 3 3 3 2 ATP synthase subunit C RPN1_RPN2_N PF17781.1 AAS51298.1 - 3.9e-112 374.7 1.0 7.5e-112 373.7 1.0 1.5 1 0 0 1 1 1 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 AAS51298.1 - 1.3e-28 98.8 0.1 2.4e-28 97.9 0.1 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 AAS51298.1 - 1.2e-27 94.9 13.1 2.5e-08 33.9 0.5 7.9 8 0 0 8 8 8 5 Proteasome/cyclosome repeat PI3K_1B_p101 PF10486.9 AAS51298.1 - 0.34 8.6 10.1 0.58 7.9 10.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Utp13 PF08625.11 AAS51298.1 - 0.49 10.3 1.9 0.78 9.6 0.2 2.3 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain MCM_bind PF09739.9 AAS51298.1 - 2.2 6.6 6.5 5.3 5.4 0.1 2.2 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 AAS51298.1 - 3.1 6.5 5.7 6.9 5.3 5.7 1.5 1 0 0 1 1 1 0 Presenilin Herpes_LMP1 PF05297.11 AAS51298.1 - 3.4 6.8 6.9 5.4 6.1 6.9 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DPPIV_N PF00930.21 AAS51299.2 - 1.2e-108 363.1 6.1 1.7e-108 362.6 6.1 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AAS51299.2 - 1.4e-52 178.3 0.3 2.6e-52 177.4 0.3 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 AAS51299.2 - 3.6e-06 27.7 0.0 0.00045 20.9 0.0 2.7 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AAS51299.2 - 0.066 12.8 0.0 1.7 8.2 0.0 2.4 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 AAS51299.2 - 0.096 12.5 0.0 0.36 10.6 0.0 1.8 1 1 0 1 1 1 0 alpha/beta hydrolase fold PD40 PF07676.12 AAS51299.2 - 0.18 11.8 0.5 3.2 7.8 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PX PF00787.24 AAS51300.1 - 1.2e-25 89.7 0.1 3.5e-25 88.2 0.1 1.8 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AAS51300.1 - 3.4e-05 23.5 5.7 3.4e-05 23.5 5.7 3.0 2 1 0 2 2 2 1 Vps5 C terminal like DASH_Dam1 PF08653.10 AAS51300.1 - 0.042 13.7 3.6 1.7 8.5 0.0 4.3 5 0 0 5 5 5 0 DASH complex subunit Dam1 FlaC_arch PF05377.11 AAS51300.1 - 0.074 13.5 8.1 6.5 7.2 0.6 4.1 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 AAS51300.1 - 0.098 13.1 2.7 4.6 7.8 0.1 3.8 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 AAS51300.1 - 0.14 12.6 2.7 0.62 10.5 0.7 3.0 3 0 0 3 3 3 0 Lipoprotein leucine-zipper DUF4618 PF15397.6 AAS51300.1 - 0.53 9.7 17.5 0.045 13.2 2.6 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4618) DUF1664 PF07889.12 AAS51300.1 - 0.53 10.3 8.4 3.4 7.7 1.3 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 AAS51300.1 - 0.75 10.3 16.7 1.9 9.0 1.3 2.6 2 1 0 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 AAS51300.1 - 1.4 9.0 9.8 3.3 7.9 2.7 3.9 4 0 0 4 4 4 0 bZIP transcription factor DUF848 PF05852.11 AAS51300.1 - 1.6 8.8 13.9 0.32 11.1 3.9 2.9 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF4407 PF14362.6 AAS51300.1 - 2.9 7.2 6.3 3.8 6.8 2.2 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) LOH1CR12 PF10158.9 AAS51300.1 - 4.2 7.4 10.5 4.3 7.4 2.2 3.4 3 1 0 3 3 3 0 Tumour suppressor protein dCMP_cyt_deam_1 PF00383.23 AAS51301.1 - 3.2e-22 78.3 0.2 4.6e-22 77.8 0.2 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AAS51301.1 - 1.4e-17 63.8 0.0 2.1e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 AAS51301.1 - 0.0013 18.8 0.0 0.0022 18.1 0.0 1.3 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 AAS51301.1 - 0.005 16.8 0.0 0.0077 16.1 0.0 1.2 1 0 0 1 1 1 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 AAS51301.1 - 0.0054 16.8 0.0 0.0082 16.2 0.0 1.2 1 0 0 1 1 1 1 APOBEC2 NAD1 PF18778.1 AAS51301.1 - 0.0078 16.3 0.0 0.012 15.7 0.0 1.2 1 0 0 1 1 1 1 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 AAS51301.1 - 0.012 15.7 1.1 0.032 14.3 0.2 2.1 2 1 0 2 2 2 0 Bd3614-like deaminase Inv-AAD PF18785.1 AAS51301.1 - 0.017 15.0 0.0 0.026 14.4 0.0 1.2 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase APOBEC3 PF18771.1 AAS51301.1 - 0.02 15.0 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 APOBEC3 FSH1 PF03959.13 AAS51302.1 - 3.4e-57 193.5 0.0 3.8e-57 193.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_6 PF12697.7 AAS51302.1 - 7.7e-06 26.7 2.7 1.2e-05 26.1 2.7 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family ATPgrasp_N PF18130.1 AAS51302.1 - 0.009 16.5 0.0 0.14 12.8 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp N-terminal domain Abhydrolase_2 PF02230.16 AAS51302.1 - 0.019 14.8 0.3 2.9 7.6 0.4 3.0 3 1 0 3 3 3 0 Phospholipase/Carboxylesterase Thioesterase PF00975.20 AAS51302.1 - 0.098 12.7 0.1 0.15 12.2 0.1 1.4 1 0 0 1 1 1 0 Thioesterase domain PAP_central PF04928.17 AAS51302.1 - 0.16 10.9 0.0 0.22 10.5 0.0 1.1 1 0 0 1 1 1 0 Poly(A) polymerase central domain DEAD PF00270.29 AAS51304.2 - 8.3e-35 120.1 0.1 1.4e-34 119.4 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51304.2 - 1.7e-27 96.0 0.0 4e-27 94.8 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.6 AAS51304.2 - 0.021 14.6 0.0 0.042 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain CMS1 PF14617.6 AAS51304.2 - 0.058 12.7 0.2 0.16 11.2 0.0 1.8 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit Pmp3 PF01679.17 AAS51305.1 - 8.8e-16 57.8 8.1 9.4e-16 57.7 8.1 1.0 1 0 0 1 1 1 1 Proteolipid membrane potential modulator DUF3099 PF11298.8 AAS51305.1 - 7.7 6.7 6.5 1.7 8.8 2.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3099) Tom6 PF17112.5 AAS51306.1 - 3.3e-26 90.5 2.3 3.9e-26 90.3 2.3 1.1 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom6, fungal TOM6p PF15184.6 AAS51306.1 - 0.028 14.2 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial import receptor subunit TOM6 homolog BTB_2 PF02214.22 AAS51308.1 - 0.076 13.4 0.0 0.22 11.9 0.0 1.8 1 0 0 1 1 1 0 BTB/POZ domain CUE PF02845.16 AAS51309.1 - 1.8e-08 33.9 0.0 3e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 CUE domain TBCA PF02970.16 AAS51309.1 - 0.22 11.9 4.0 0.31 11.4 0.2 2.5 2 0 0 2 2 2 0 Tubulin binding cofactor A DUF2756 PF10956.8 AAS51309.1 - 1.3 9.6 4.4 0.93 10.0 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2756) OmpH PF03938.14 AAS51309.1 - 2.6 8.4 9.1 0.58 10.5 4.6 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) HAGH_C PF16123.5 AAS51310.1 - 1.2e-18 67.3 0.0 2.5e-18 66.4 0.0 1.5 1 0 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus Lactamase_B PF00753.27 AAS51310.1 - 2.8e-13 50.3 0.4 6.5e-13 49.1 0.4 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AAS51310.1 - 1.4e-05 24.7 0.8 4e-05 23.2 0.8 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain WD40 PF00400.32 AAS51311.1 - 0.00081 20.2 1.0 19 6.3 0.0 6.3 6 0 0 6 6 6 1 WD domain, G-beta repeat E1-E2_ATPase PF00122.20 AAS51312.2 - 1e-42 145.7 0.0 2.3e-42 144.5 0.0 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AAS51312.2 - 1.2e-29 104.1 0.0 2.4e-29 103.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AAS51312.2 - 4.1e-14 52.7 3.4 9.3e-14 51.6 3.4 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 AAS51312.2 - 0.0087 15.8 0.0 3.6 7.3 0.1 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 AAS51312.2 - 0.012 16.0 0.8 0.073 13.5 0.1 2.6 3 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase CK_II_beta PF01214.18 AAS51313.1 - 5.4e-71 238.2 0.1 6.5e-71 237.9 0.1 1.1 1 0 0 1 1 1 1 Casein kinase II regulatory subunit RecG_N PF17190.4 AAS51313.1 - 0.076 13.7 1.0 0.21 12.3 0.4 1.9 2 0 0 2 2 2 0 RecG N-terminal helical domain Hira PF07569.11 AAS51314.2 - 1e-82 277.2 1.0 2.9e-81 272.4 0.0 3.1 3 0 0 3 3 3 1 TUP1-like enhancer of split HIRA_B PF09453.10 AAS51314.2 - 0.073 12.9 0.5 0.2 11.5 0.5 1.8 1 0 0 1 1 1 0 HIRA B motif PALB2_WD40 PF16756.5 AAS51314.2 - 0.076 11.9 0.0 10 4.9 0.0 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 AAS51314.2 - 0.11 13.4 0.5 14 6.7 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat Mcl1_mid PF12341.8 AAS51314.2 - 0.11 11.8 0.0 1.9 7.7 0.0 2.6 3 0 0 3 3 3 0 Minichromosome loss protein, Mcl1, middle region tRNA-synt_1b PF00579.25 AAS51315.1 - 1.1e-70 238.3 0.0 1.4e-70 237.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) NCD1 PF04904.13 AAS51315.1 - 0.017 15.1 0.0 0.055 13.5 0.0 1.8 2 0 0 2 2 2 0 NAB conserved region 1 (NCD1) FAD_binding_6 PF00970.24 AAS51316.2 - 0.00011 22.5 0.0 0.00073 19.8 0.0 2.1 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain WD40 PF00400.32 AAS51317.1 - 5.5e-34 115.6 27.0 1.8e-08 34.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51317.1 - 1.7e-11 44.3 10.0 0.00038 20.7 0.0 5.5 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS51317.1 - 0.0011 18.9 0.3 0.0044 16.9 0.0 2.1 3 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A IKI3 PF04762.12 AAS51317.1 - 0.017 13.2 2.1 0.03 12.3 2.1 1.4 1 0 0 1 1 1 0 IKI3 family Coatomer_WDAD PF04053.14 AAS51317.1 - 0.052 12.6 6.6 0.045 12.8 0.6 2.8 2 1 1 3 3 3 0 Coatomer WD associated region CRT10 PF08728.10 AAS51317.1 - 0.19 9.8 0.4 2.7 6.1 0.0 2.6 2 1 0 3 3 3 0 CRT10 Syntaxin_2 PF14523.6 AAS51318.1 - 3e-18 66.0 8.7 1.9e-17 63.5 1.8 2.2 2 0 0 2 2 2 2 Syntaxin-like protein SNARE PF05739.19 AAS51318.1 - 2.2e-12 46.7 0.0 5.4e-12 45.5 0.0 1.7 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 AAS51318.1 - 2.7e-05 23.9 10.2 3.8e-05 23.4 10.2 1.3 1 0 0 1 1 1 1 Syntaxin Baculo_PEP_C PF04513.12 AAS51318.1 - 0.0013 18.8 3.1 0.42 10.6 0.2 2.5 2 0 0 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus CK2S PF15011.6 AAS51318.1 - 0.03 14.2 7.9 0.61 10.0 3.3 2.2 2 0 0 2 2 2 0 Casein Kinase 2 substrate DUF2207 PF09972.9 AAS51318.1 - 0.058 12.1 0.0 0.098 11.4 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Plk4_PB2 PF18409.1 AAS51318.1 - 0.56 10.9 3.2 3.1 8.5 0.7 2.4 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 BORCS6 PF10157.9 AAS51318.1 - 0.86 9.8 4.8 0.84 9.9 0.3 2.3 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 6 GP52 PF17468.2 AAS51319.2 - 0.19 11.9 0.1 6.7 6.9 0.0 2.7 2 0 0 2 2 2 0 Phage gene product 52 Parecho_VpG PF06344.11 AAS51319.2 - 0.4 11.4 3.1 0.23 12.1 0.6 1.9 2 0 0 2 2 2 0 Parechovirus Genome-linked protein PPTA PF01239.22 AAS51320.1 - 4.5e-33 112.0 14.2 3.8e-07 29.6 0.2 5.6 6 0 0 6 6 6 5 Protein prenyltransferase alpha subunit repeat Linker_histone PF00538.19 AAS51321.1 - 4.6e-23 81.4 0.0 4.6e-23 81.4 0.0 2.3 2 1 1 3 3 3 1 linker histone H1 and H5 family SRP-alpha_N PF04086.13 AAS51321.1 - 4 7.3 12.5 4.9 7.0 12.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TRF PF08558.10 AAS51322.1 - 3.1e-78 262.7 0.1 4.3e-78 262.2 0.1 1.2 1 0 0 1 1 1 1 Telomere repeat binding factor (TRF) Myb_DNA-binding PF00249.31 AAS51322.1 - 5.3e-07 29.7 0.5 1.4e-06 28.4 0.5 1.7 1 1 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS51322.1 - 0.0027 17.9 0.1 0.0063 16.7 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PBC PF03792.13 AAS51322.1 - 0.11 12.3 0.3 0.26 11.0 0.1 1.7 2 0 0 2 2 2 0 PBC domain WD40 PF00400.32 AAS51323.1 - 2.3e-29 101.0 21.2 1.2e-05 25.9 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51323.1 - 4e-13 49.5 0.1 0.077 13.3 0.0 5.1 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS51323.1 - 2.1e-05 24.0 1.2 0.0045 16.4 0.2 2.5 2 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 AAS51323.1 - 3.9e-05 22.8 1.0 1.1 8.2 0.1 4.0 3 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Big_7 PF17957.1 AAS51323.1 - 0.039 14.7 0.9 0.92 10.3 0.2 3.2 3 1 0 3 3 3 0 Bacterial Ig domain YEATS PF03366.16 AAS51324.1 - 2.4e-16 59.4 0.0 3.8e-16 58.8 0.0 1.3 1 0 0 1 1 1 1 YEATS family YEATS PF03366.16 AAS51325.1 - 9.8e-21 73.5 0.0 1.6e-20 72.8 0.0 1.3 1 0 0 1 1 1 1 YEATS family BET PF17035.5 AAS51325.1 - 8.2e-07 29.1 0.0 1.6e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation YqeY PF09424.10 AAS51326.1 - 5.2e-23 81.7 0.3 8.2e-23 81.1 0.3 1.3 1 0 0 1 1 1 1 Yqey-like protein Pox_A3L PF05288.11 AAS51326.1 - 0.0099 15.8 0.2 0.018 15.0 0.2 1.4 1 0 0 1 1 1 1 Poxvirus A3L Protein GRAB PF10375.9 AAS51327.2 - 1.1e-07 31.5 2.8 2.5e-07 30.3 2.8 1.7 1 0 0 1 1 1 1 GRIP-related Arf-binding domain Spc7 PF08317.11 AAS51327.2 - 0.015 14.2 62.5 0.49 9.2 23.9 3.5 1 1 3 4 4 4 0 Spc7 kinetochore protein MAD PF05557.13 AAS51327.2 - 0.024 13.0 63.6 0.27 9.5 35.3 3.0 1 1 2 3 3 3 0 Mitotic checkpoint protein GAS PF13851.6 AAS51327.2 - 0.41 10.0 64.0 0.075 12.4 13.5 4.0 1 1 4 5 5 5 0 Growth-arrest specific micro-tubule binding Jnk-SapK_ap_N PF09744.9 AAS51327.2 - 0.62 10.3 69.5 4.6 7.4 23.7 4.4 2 1 3 5 5 5 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 AAS51327.2 - 1.2 9.3 75.2 0.09 13.0 29.3 3.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 AAS51327.2 - 1.3 9.0 29.2 0.76 9.8 2.1 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Raco_middle PF17651.1 AAS51327.2 - 2.3 7.9 4.1 0.78 9.4 0.4 2.2 2 1 0 2 2 2 0 RACo middle region ADIP PF11559.8 AAS51327.2 - 2.7 8.0 62.1 0.075 13.1 11.4 4.7 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding FPP PF05911.11 AAS51327.2 - 3 5.9 63.0 0.24 9.6 27.5 2.5 2 1 1 3 3 3 0 Filament-like plant protein, long coiled-coil DUF812 PF05667.11 AAS51327.2 - 5.6 5.7 56.8 3.1 6.6 39.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) MscS_porin PF12795.7 AAS51327.2 - 6.3 6.3 67.0 1 8.9 20.3 3.4 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain SHE3 PF17078.5 AAS51327.2 - 7.8 6.1 46.1 3.3 7.4 18.1 3.5 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 EzrA PF06160.12 AAS51327.2 - 8.3 4.5 46.4 0.0086 14.3 17.9 2.1 1 1 1 2 2 1 0 Septation ring formation regulator, EzrA HOOK PF05622.12 AAS51327.2 - 8.4 4.4 60.5 0.041 12.0 16.1 2.9 1 1 2 3 3 3 0 HOOK protein RFC1 PF08519.12 AAS51328.2 - 1.4e-57 194.3 0.1 3.8e-57 192.9 0.1 1.8 1 0 0 1 1 1 1 Replication factor RFC1 C terminal domain AAA PF00004.29 AAS51328.2 - 2.4e-13 50.6 0.0 6.4e-13 49.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) BRCT PF00533.26 AAS51328.2 - 2.6e-12 46.9 0.0 6.3e-12 45.7 0.0 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RuvB_N PF05496.12 AAS51328.2 - 3.2e-05 23.7 0.0 6.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AAS51328.2 - 8.1e-05 22.9 0.0 0.00022 21.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 AAS51328.2 - 0.00013 22.0 0.0 0.00029 20.8 0.0 1.6 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 AAS51328.2 - 0.0002 21.8 0.1 0.0021 18.4 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 AAS51328.2 - 0.0011 19.1 1.2 0.0018 18.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_14 PF13173.6 AAS51328.2 - 0.0018 18.3 0.0 0.0047 17.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_assoc_2 PF16193.5 AAS51328.2 - 0.0044 17.3 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 AAA C-terminal domain AAA_17 PF13207.6 AAS51328.2 - 0.0057 17.1 0.4 0.019 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AAS51328.2 - 0.0059 17.2 0.0 0.017 15.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AAS51328.2 - 0.013 15.9 0.0 0.03 14.7 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 AAS51328.2 - 0.031 14.0 0.0 0.077 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain SAGA-Tad1 PF12767.7 AAS51328.2 - 0.041 13.6 1.1 0.22 11.2 1.1 2.2 1 1 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit AAA_28 PF13521.6 AAS51328.2 - 0.043 14.1 0.3 0.16 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AAS51328.2 - 0.067 13.1 0.0 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 NTPase NACHT PF05729.12 AAS51328.2 - 0.088 12.7 0.0 0.71 9.8 0.0 2.5 3 0 0 3 3 3 0 NACHT domain AAA_5 PF07728.14 AAS51328.2 - 0.097 12.7 0.0 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DPPIV_N PF00930.21 AAS51329.2 - 2.3e-96 322.6 0.0 3.5e-96 322.1 0.0 1.3 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9 PF00326.21 AAS51329.2 - 2.1e-48 164.6 0.4 3.6e-48 163.8 0.4 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family PAF-AH_p_II PF03403.13 AAS51329.2 - 3.2e-05 22.6 0.0 0.0033 16.0 0.0 2.2 2 0 0 2 2 2 2 Platelet-activating factor acetylhydrolase, isoform II Esterase PF00756.20 AAS51329.2 - 0.0002 21.1 0.0 0.00043 20.0 0.0 1.5 1 0 0 1 1 1 1 Putative esterase Abhydrolase_6 PF12697.7 AAS51329.2 - 0.0038 17.8 0.0 0.13 12.9 0.0 2.9 2 1 1 3 3 3 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS51329.2 - 0.0091 15.3 0.0 0.51 9.6 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Ribosomal_L5e PF17144.4 AAS51330.1 - 7.7e-83 276.4 0.9 8e-83 276.3 0.0 1.5 2 0 0 2 2 2 1 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AAS51330.1 - 3.5e-33 114.4 2.5 3.5e-33 114.4 2.5 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region Ribosomal_L18p PF00861.22 AAS51330.1 - 0.018 15.4 1.2 0.05 14.0 0.0 2.0 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Thr_synth_N PF14821.6 AAS51330.1 - 0.069 13.4 0.2 0.88 9.8 0.0 2.6 3 0 0 3 3 3 0 Threonine synthase N terminus CtaG_Cox11 PF04442.14 AAS51332.1 - 2.2e-61 206.3 0.0 3.1e-61 205.8 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 Zn_clus PF00172.18 AAS51333.2 - 0.00052 20.1 12.6 0.0013 18.8 12.6 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Acyl_transf_1 PF00698.21 AAS51334.1 - 0.00017 21.2 1.5 0.00027 20.5 1.5 1.4 1 0 0 1 1 1 1 Acyl transferase domain Mito_carr PF00153.27 AAS51335.2 - 2.9e-64 213.0 0.6 8.3e-25 86.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF2407_C PF13373.6 AAS51336.1 - 1e-36 126.2 0.2 1.6e-36 125.5 0.2 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain DUF2407 PF10302.9 AAS51336.1 - 7.3e-15 55.4 1.4 2e-12 47.6 1.4 2.3 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain TMEM65 PF10507.9 AAS51336.1 - 0.1 12.6 0.4 0.36 10.8 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 65 DUF4257 PF14074.6 AAS51336.1 - 0.14 12.4 3.0 0.22 11.7 3.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4257) SICA_alpha PF12887.7 AAS51336.1 - 0.15 12.0 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 SICA extracellular alpha domain MerR-DNA-bind PF09278.11 AAS51336.1 - 0.17 12.5 1.3 20 5.8 0.4 2.8 2 1 0 2 2 2 0 MerR, DNA binding RNA_pol_Rpb8 PF03870.15 AAS51337.1 - 4.8e-45 153.2 0.0 5.3e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 AAS51337.1 - 0.0056 16.7 0.1 3.6 7.7 0.0 2.0 2 0 0 2 2 2 2 DNA-directed RNA polymerase, subunit G NifU_N PF01592.16 AAS51338.1 - 5e-57 191.6 0.1 5.8e-57 191.4 0.1 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain DUF1691 PF07950.11 AAS51340.1 - 7.5e-23 81.3 6.2 6.9e-14 52.5 0.1 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1691) MPC PF03650.13 AAS51340.1 - 0.035 14.3 0.1 0.2 11.8 0.1 2.1 2 0 0 2 2 2 0 Mitochondrial pyruvate carriers DUF4405 PF14358.6 AAS51340.1 - 1.1 9.8 6.6 0.28 11.7 1.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) PHD PF00628.29 AAS51341.2 - 2.5e-11 43.3 3.9 2.5e-11 43.3 3.9 1.8 2 0 0 2 2 2 1 PHD-finger zf-RING_2 PF13639.6 AAS51341.2 - 0.087 13.2 5.5 0.29 11.5 5.5 1.9 1 0 0 1 1 1 0 Ring finger domain zf-HC5HC2H PF13771.6 AAS51341.2 - 2.5 8.4 8.0 0.18 12.1 2.4 2.0 1 1 1 2 2 2 0 PHD-like zinc-binding domain WD40 PF00400.32 AAS51342.2 - 3.4e-06 27.7 4.1 0.0016 19.2 0.2 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Pkinase PF00069.25 AAS51343.1 - 3.6e-72 242.9 0.0 4.5e-72 242.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51343.1 - 6.4e-38 130.5 0.0 1e-37 129.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51343.1 - 1.1e-07 31.4 0.0 2.4e-07 30.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 AAS51343.1 - 3e-05 23.7 0.1 0.11 12.2 0.1 2.2 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AAS51343.1 - 3.8e-05 22.6 0.0 5.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AAS51343.1 - 0.0019 17.6 0.0 0.0031 16.9 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS51343.1 - 0.0051 16.8 0.0 0.12 12.3 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS51343.1 - 0.045 12.7 0.0 0.084 11.8 0.0 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 AAS51343.1 - 0.093 11.8 0.0 0.14 11.2 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 GrpE PF01025.19 AAS51344.1 - 6.7e-47 159.2 0.0 8.2e-47 158.9 0.0 1.0 1 0 0 1 1 1 1 GrpE PKcGMP_CC PF16808.5 AAS51344.1 - 0.00068 19.4 0.1 0.0015 18.4 0.1 1.5 1 0 0 1 1 1 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4515 PF14988.6 AAS51344.1 - 0.025 14.4 0.1 0.035 13.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) Ofd1_CTDD PF10637.9 AAS51344.1 - 0.14 11.5 0.1 0.2 11.0 0.1 1.1 1 0 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term Pkinase PF00069.25 AAS51345.2 - 3.5e-62 210.1 0.0 4.9e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51345.2 - 1.4e-36 126.1 0.0 2.1e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51345.2 - 2.6e-07 30.3 0.0 4.2e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AAS51345.2 - 0.026 14.5 0.2 0.37 10.7 0.2 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family Ribosomal_L35Ae PF01247.18 AAS51346.1 - 2.7e-42 142.9 0.6 3e-42 142.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L35Ae RimM PF01782.18 AAS51346.1 - 0.00014 22.0 0.0 0.13 12.4 0.0 2.2 2 0 0 2 2 2 2 RimM N-terminal domain Pyr_redox_3 PF13738.6 AAS51348.2 - 1.5e-20 73.7 0.0 4.5e-19 68.8 0.0 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 AAS51348.2 - 7.6e-19 67.5 0.0 1.6e-11 43.4 0.0 2.3 2 1 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 AAS51348.2 - 1.7e-12 47.2 0.0 1.3e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AAS51348.2 - 2.8e-11 43.2 0.0 9.9e-08 31.5 0.0 3.1 3 0 0 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 AAS51348.2 - 0.0001 22.5 2.7 0.00025 21.2 0.1 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 AAS51348.2 - 0.00022 20.6 0.1 0.0004 19.8 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 AAS51348.2 - 0.00093 18.6 0.0 0.019 14.3 0.0 2.2 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 AAS51348.2 - 0.0011 19.3 0.0 0.16 12.5 0.0 2.7 2 1 0 2 2 2 1 Putative NAD(P)-binding Pyr_redox PF00070.27 AAS51348.2 - 0.004 17.7 0.4 0.95 10.1 0.1 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AAS51348.2 - 0.0065 15.6 0.5 0.025 13.7 0.5 1.9 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 AAS51348.2 - 0.022 14.3 0.9 0.77 9.3 0.1 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase Shikimate_DH PF01488.20 AAS51348.2 - 0.046 13.8 0.0 24 5.0 0.0 3.0 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase HI0933_like PF03486.14 AAS51348.2 - 0.091 11.4 0.1 0.14 10.8 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein Lycopene_cycl PF05834.12 AAS51348.2 - 0.14 11.2 0.0 0.22 10.5 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein POC3_POC4 PF10448.9 AAS51349.1 - 3.3e-23 82.3 0.0 3.7e-23 82.1 0.0 1.0 1 0 0 1 1 1 1 20S proteasome chaperone assembly proteins 3 and 4 PAC4 PF16093.5 AAS51349.1 - 0.024 14.8 0.0 0.039 14.2 0.0 1.4 1 1 0 1 1 1 0 Proteasome assembly chaperone 4 DHFR_1 PF00186.19 AAS51350.1 - 1e-28 100.1 0.0 1.4e-28 99.6 0.0 1.2 1 0 0 1 1 1 1 Dihydrofolate reductase Oxysterol_BP PF01237.18 AAS51351.1 - 7.4e-63 212.6 0.4 1.1e-60 205.4 0.4 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein Nop53 PF07767.11 AAS51352.1 - 9.3e-100 334.8 42.6 1.1e-99 334.6 42.6 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF4407 PF14362.6 AAS51352.1 - 5.9 6.2 14.1 13 5.0 14.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_membrane_2 PF06472.15 AAS51354.2 - 2.9e-85 285.9 6.7 4.4e-85 285.4 6.7 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AAS51354.2 - 6.1e-14 52.7 0.0 1.6e-13 51.3 0.0 1.7 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AAS51354.2 - 0.0042 16.5 0.1 0.28 10.6 0.0 2.1 1 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain ComFB PF10719.9 AAS51354.2 - 0.15 12.1 0.0 0.45 10.6 0.0 1.8 1 0 0 1 1 1 0 Late competence development protein ComFB ACPS PF01648.20 AAS51355.2 - 4.8e-15 55.7 0.0 6.7e-15 55.2 0.0 1.2 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily 4PPT_N PF17837.1 AAS51355.2 - 0.051 13.7 0.3 3.7 7.7 0.3 2.4 1 1 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain Methyltransf_23 PF13489.6 AAS51356.2 - 3.7e-17 62.7 0.0 1e-16 61.2 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS51356.2 - 7.7e-17 61.9 7.1 2.8e-16 60.1 0.0 3.5 4 0 0 4 4 4 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS51356.2 - 1.6e-14 54.4 0.0 2.3e-13 50.7 0.0 2.8 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS51356.2 - 3.5e-11 43.6 0.0 2.3e-10 41.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 AAS51356.2 - 0.00018 20.8 0.0 0.09 11.9 0.0 2.3 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family Methyltransf_24 PF13578.6 AAS51356.2 - 0.0023 18.9 0.1 0.01 16.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain TPMT PF05724.11 AAS51356.2 - 0.0059 16.3 0.1 0.057 13.1 0.0 2.5 2 1 0 2 2 2 1 Thiopurine S-methyltransferase (TPMT) MTS PF05175.14 AAS51356.2 - 0.0099 15.4 0.0 0.038 13.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 AAS51356.2 - 0.29 11.1 0.0 0.29 11.1 0.0 3.1 3 1 0 3 3 2 0 Methyltransferase domain Glyco_hydro_52 PF03512.13 AAS51356.2 - 0.37 9.7 5.8 0.62 9.0 5.8 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 52 Macoilin PF09726.9 AAS51356.2 - 1.3 7.5 17.2 1.8 7.0 17.2 1.3 1 0 0 1 1 1 0 Macoilin family APG5 PF04106.12 AAS51357.2 - 1.4e-42 145.9 0.0 1.7e-42 145.5 0.0 1.1 1 0 0 1 1 1 1 Autophagy protein Apg5 SGT1 PF07093.11 AAS51358.1 - 3.3e-13 49.0 0.1 6.3e-13 48.0 0.0 1.4 2 0 0 2 2 2 1 SGT1 protein Pkinase PF00069.25 AAS51359.1 - 4e-64 216.5 0.0 6.1e-64 215.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51359.1 - 2.5e-35 122.0 0.0 3.9e-35 121.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51359.1 - 2.3e-09 37.0 0.0 1.1e-08 34.8 0.0 2.0 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 AAS51359.1 - 0.0019 17.2 0.0 0.0019 17.2 0.0 2.8 3 0 0 3 3 3 1 Haspin like kinase domain APH PF01636.23 AAS51359.1 - 0.024 14.6 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 AAS51359.1 - 0.028 13.8 0.1 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Mur_ligase_M PF08245.12 AAS51360.2 - 9.9e-06 25.7 1.1 0.0013 18.8 0.1 3.0 1 1 1 2 2 2 2 Mur ligase middle domain Mur_ligase_C PF02875.21 AAS51360.2 - 0.0021 18.2 0.0 0.0046 17.2 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain RRM_1 PF00076.22 AAS51361.1 - 0.021 14.6 0.0 0.053 13.3 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TruD PF01142.18 AAS51362.1 - 2.8e-80 270.2 2.1 1.6e-73 247.9 0.1 3.3 1 1 1 2 2 2 2 tRNA pseudouridine synthase D (TruD) YhzD PF14120.6 AAS51362.1 - 0.025 14.7 0.5 0.09 12.9 0.1 2.1 2 0 0 2 2 2 0 YhzD-like protein RST PF12174.8 AAS51362.1 - 0.16 11.9 0.6 18 5.3 0.0 3.4 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain WD40 PF00400.32 AAS51363.2 - 2.3e-31 107.3 19.3 9e-07 29.5 3.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat Nucleoporin_N PF08801.11 AAS51363.2 - 0.00012 20.9 0.2 2.1 7.0 0.0 4.0 1 1 4 5 5 5 3 Nup133 N terminal like Nup160 PF11715.8 AAS51363.2 - 0.0044 15.7 7.3 1.5 7.4 0.1 4.0 1 1 2 4 4 4 4 Nucleoporin Nup120/160 MOZ_SAS PF01853.18 AAS51364.2 - 3e-82 274.6 0.2 4.3e-82 274.1 0.2 1.2 1 0 0 1 1 1 1 MOZ/SAS family Tudor-knot PF11717.8 AAS51364.2 - 1.2e-22 79.5 0.1 2.4e-22 78.6 0.1 1.6 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-MYST PF17772.1 AAS51364.2 - 1.7e-20 72.4 0.2 4.7e-20 70.9 0.2 1.8 1 0 0 1 1 1 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AAS51364.2 - 0.0015 19.0 0.0 0.0039 17.6 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AAS51364.2 - 0.005 17.1 0.0 0.015 15.5 0.0 1.8 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family PTPA PF03095.15 AAS51365.1 - 6.4e-113 377.2 0.0 7.5e-113 377.0 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein FabA PF07977.13 AAS51365.1 - 0.071 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 FabA-like domain UDPG_MGDP_dh_C PF03720.15 AAS51365.1 - 0.084 13.3 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain DAGAT PF03982.13 AAS51366.1 - 2e-82 276.4 2.6 1.5e-75 253.9 0.0 2.1 1 1 1 2 2 2 2 Diacylglycerol acyltransferase LicD PF04991.13 AAS51367.2 - 1.5e-19 71.0 2.2 2.5e-15 57.3 1.4 2.1 1 1 1 2 2 2 2 LicD family DUF885 PF05960.11 AAS51367.2 - 0.02 14.6 7.0 0.029 14.0 7.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Pkinase PF00069.25 AAS51368.2 - 1.1e-78 264.3 0.0 1.8e-78 263.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51368.2 - 2.1e-37 128.8 0.0 3.2e-37 128.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AAS51368.2 - 3.1e-25 88.3 0.9 6.6e-14 52.0 0.1 2.7 2 0 0 2 2 2 2 FHA domain Yop-YscD_cpl PF16697.5 AAS51368.2 - 7e-09 35.9 0.0 7.6e-08 32.6 0.1 2.4 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Kinase-like PF14531.6 AAS51368.2 - 2.9e-08 33.4 0.0 5.8e-08 32.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AAS51368.2 - 2.7e-06 27.5 0.0 0.0033 17.4 0.1 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AAS51368.2 - 6.8e-06 25.6 0.0 1.7e-05 24.3 0.0 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 AAS51368.2 - 0.0013 18.4 0.0 0.0029 17.2 0.0 1.5 1 0 0 1 1 1 1 RIO1 family FHA_2 PF17913.1 AAS51368.2 - 0.0025 18.0 0.2 13 6.1 0.0 3.6 3 0 0 3 3 3 1 FHA domain Haspin_kinase PF12330.8 AAS51368.2 - 0.091 11.7 0.4 0.17 10.8 0.0 1.6 2 0 0 2 2 2 0 Haspin like kinase domain Asp PF00026.23 AAS51369.1 - 8e-78 262.0 0.2 9.4e-78 261.8 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AAS51369.1 - 8.7e-11 42.4 0.8 2.2e-08 34.6 0.1 3.0 2 1 1 3 3 3 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 AAS51369.1 - 0.00065 20.3 0.2 4.4 8.0 0.0 3.7 2 1 1 3 3 3 2 Aspartyl protease TAXi_C PF14541.6 AAS51369.1 - 0.0019 18.0 0.0 0.16 11.7 0.0 2.4 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 AAS51369.1 - 0.29 11.7 0.8 27 5.4 0.1 3.4 4 0 0 4 4 4 0 gag-polyprotein putative aspartyl protease Asp PF00026.23 AAS51370.1 - 7e-97 324.6 0.0 9e-97 324.3 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AAS51370.1 - 4.6e-14 53.0 0.2 5e-09 36.6 0.1 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AAS51370.1 - 7.9e-05 22.5 0.0 0.0011 18.8 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AAS51370.1 - 0.002 18.7 0.0 0.1 13.2 0.0 2.7 2 0 0 2 2 2 1 Aspartyl protease gag-asp_proteas PF13975.6 AAS51370.1 - 0.045 14.3 0.0 0.54 10.8 0.0 2.5 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease Kinesin PF00225.23 AAS51371.1 - 1.2e-103 346.5 0.1 1.2e-103 346.5 0.1 1.5 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AAS51371.1 - 1.5e-26 93.1 0.0 4.1e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 Microtubule binding MPS2 PF17060.5 AAS51371.1 - 1.3 8.2 7.9 0.11 11.7 0.2 2.2 1 1 0 2 2 2 0 Monopolar spindle protein 2 Med9 PF07544.13 AAS51371.1 - 8.4 6.6 13.2 3.2 7.9 4.0 3.6 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Methyltransf_15 PF09445.10 AAS51373.1 - 1.9e-66 222.7 0.0 2.6e-66 222.3 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 AAS51373.1 - 7.2e-06 26.6 0.0 1.7e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AAS51373.1 - 1.6e-05 24.7 0.0 4.2e-05 23.3 0.0 1.7 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 CMAS PF02353.20 AAS51373.1 - 0.0042 16.4 0.0 0.0067 15.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase N6_Mtase PF02384.16 AAS51373.1 - 0.015 14.6 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_31 PF13847.6 AAS51373.1 - 0.024 14.5 0.0 0.035 13.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain NLE PF08154.12 AAS51373.1 - 0.048 14.2 0.7 3.9 8.1 0.1 2.2 1 1 1 2 2 2 0 NLE (NUC135) domain Methyltransf_11 PF08241.12 AAS51373.1 - 0.14 12.8 0.0 0.28 11.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Abhydrolase_1 PF00561.20 AAS51375.1 - 2.5e-13 50.2 0.1 2.5e-12 47.0 0.1 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AAS51375.1 - 8.2e-08 31.8 0.0 1.3e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 AAS51375.1 - 0.00015 22.5 0.0 0.00028 21.6 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 AAS51375.1 - 0.03 14.2 0.0 0.066 13.1 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) CCDC71L PF15374.6 AAS51375.1 - 0.24 10.6 0.0 0.34 10.1 0.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Asp PF00026.23 AAS51376.1 - 5.7e-23 81.8 0.0 2.4e-22 79.8 0.0 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease Sec23_trunk PF04811.15 AAS51377.2 - 1.1e-53 182.3 0.0 2.3e-53 181.3 0.0 1.5 2 0 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AAS51377.2 - 4.8e-18 64.9 0.4 9e-18 64.0 0.4 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Sec23_BS PF08033.12 AAS51377.2 - 5e-14 52.8 0.1 9.2e-14 52.0 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 AAS51377.2 - 3.8e-10 39.6 4.8 8.1e-10 38.6 4.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AAS51377.2 - 3.1e-06 27.0 0.0 9e-06 25.5 0.0 1.7 1 0 0 1 1 1 1 Gelsolin repeat VWA_2 PF13519.6 AAS51377.2 - 0.0061 17.2 0.0 0.043 14.5 0.0 2.3 2 0 0 2 2 2 1 von Willebrand factor type A domain zf-RING_5 PF14634.6 AAS51377.2 - 0.55 10.2 3.4 4 7.5 0.7 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Pal1 PF08316.11 AAS51378.1 - 3.4e-51 173.6 0.9 3.4e-51 173.6 0.9 2.4 3 0 0 3 3 3 1 Pal1 cell morphology protein NPR3 PF03666.13 AAS51378.1 - 1.8 7.3 3.8 3.3 6.4 3.8 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TMEM174 PF15029.6 AAS51378.1 - 3.4 7.3 4.0 0.69 9.6 0.2 1.8 2 0 0 2 2 2 0 Transmembrane protein 174 Sod_Fe_C PF02777.18 AAS51379.1 - 6.6e-12 45.5 0.1 7.6e-10 38.9 0.1 2.4 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain APG6 PF04111.12 AAS51380.1 - 1.8e-62 210.5 0.0 3.8e-62 209.4 0.0 1.5 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 AAS51380.1 - 2.8e-24 86.1 20.1 2.8e-24 86.1 20.1 1.9 3 0 0 3 3 3 1 Apg6 coiled-coil region JIP_LZII PF16471.5 AAS51380.1 - 0.073 13.2 8.7 0.27 11.4 6.8 2.6 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II ORC_WH_C PF18137.1 AAS51380.1 - 0.22 11.6 7.5 0.1 12.6 4.7 1.7 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal V_ATPase_I PF01496.19 AAS51380.1 - 0.37 8.7 5.4 0.53 8.1 5.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 AAS51380.1 - 0.37 10.1 3.2 0.71 9.2 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BRE1 PF08647.11 AAS51380.1 - 2.4 8.3 20.1 1.4 9.0 11.8 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase E2F_CC-MB PF16421.5 AAS51380.1 - 3.5 8.0 8.9 0.48 10.8 3.4 2.4 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain PhoU PF01895.19 AAS51380.1 - 10 6.7 10.4 1 9.9 2.7 2.9 2 1 1 3 3 3 0 PhoU domain Ribonuc_red_lgC PF02867.15 AAS51381.1 - 2.9e-181 603.6 0.0 5.1e-181 602.8 0.0 1.4 2 0 0 2 2 2 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AAS51381.1 - 1.4e-24 85.9 0.1 4e-24 84.4 0.0 1.9 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AAS51381.1 - 0.0022 18.5 0.0 0.0052 17.3 0.0 1.7 1 0 0 1 1 1 1 ATP cone domain Ribonuclease_T2 PF00445.18 AAS51382.1 - 2e-31 109.6 0.0 3e-31 109.1 0.0 1.2 1 0 0 1 1 1 1 Ribonuclease T2 family Spc29 PF17082.5 AAS51383.1 - 1.3e-82 277.3 0.1 1.7e-82 276.9 0.1 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 SlyX PF04102.12 AAS51383.1 - 3 8.5 6.1 14 6.4 0.3 3.3 3 0 0 3 3 3 0 SlyX HIP1_clath_bdg PF16515.5 AAS51383.1 - 3.3 8.4 5.9 0.63 10.7 0.3 2.4 3 0 0 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Y_phosphatase PF00102.27 AAS51384.2 - 2.7e-59 200.6 0.2 7.4e-59 199.2 0.1 1.8 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 AAS51384.2 - 0.003 17.6 0.2 0.0079 16.2 0.2 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family Imm41 PF15592.6 AAS51384.2 - 0.022 15.1 0.4 0.067 13.5 0.1 2.0 2 0 0 2 2 2 0 Immunity protein 41 PTPlike_phytase PF14566.6 AAS51384.2 - 0.023 14.8 0.3 0.47 10.6 0.0 2.8 3 0 0 3 3 3 0 Inositol hexakisphosphate HBD PF18534.1 AAS51384.2 - 0.027 14.6 0.2 13 6.0 0.0 2.6 2 0 0 2 2 2 0 Helical bundle domain DSPc PF00782.20 AAS51384.2 - 0.046 13.5 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain IBN_N PF03810.19 AAS51385.2 - 3.9e-14 52.3 1.6 1.9e-13 50.1 0.4 2.8 3 0 0 3 3 3 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AAS51385.2 - 0.026 14.6 6.3 0.091 12.8 0.1 4.4 5 0 0 5 5 5 0 Exportin 1-like protein NAPRTase PF04095.16 AAS51386.1 - 1.2e-69 234.7 0.0 1.4e-69 234.3 0.0 1.1 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 AAS51386.1 - 3.5e-32 111.4 0.3 5.8e-32 110.7 0.3 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain ANAPC4_WD40 PF12894.7 AAS51388.1 - 0.0001 22.5 0.1 2.5 8.4 0.0 5.2 5 0 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS51388.1 - 0.00028 21.6 8.0 0.28 12.1 0.8 5.5 4 1 0 4 4 4 1 WD domain, G-beta repeat Arr-ms PF12120.8 AAS51388.1 - 0.067 13.4 0.1 0.8 9.9 0.0 2.7 3 0 0 3 3 3 0 Rifampin ADP-ribosyl transferase Vault_3 PF17795.1 AAS51388.1 - 0.17 12.0 0.4 0.74 9.9 0.1 2.2 2 0 0 2 2 2 0 Major Vault Protein Repeat domain TANGO2 PF05742.12 AAS51388.1 - 0.31 11.1 1.8 0.33 11.0 0.2 1.8 2 0 0 2 2 2 0 Transport and Golgi organisation 2 RNA_pol_N PF01194.17 AAS51389.1 - 4.2e-30 103.8 0.5 4.8e-30 103.6 0.5 1.0 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Chordopox_RPO7 PF05864.12 AAS51389.1 - 0.036 14.3 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Dynamin_N PF00350.23 AAS51390.2 - 1e-43 149.3 0.6 3e-43 147.8 0.0 2.2 2 0 0 2 2 2 1 Dynamin family MMR_HSR1 PF01926.23 AAS51390.2 - 2.9e-05 24.1 0.0 0.00012 22.1 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_M PF01031.20 AAS51390.2 - 0.00026 20.3 9.1 0.056 12.7 0.0 3.3 4 0 0 4 4 4 2 Dynamin central region AAA_16 PF13191.6 AAS51390.2 - 0.0033 17.8 0.4 0.041 14.3 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.6 AAS51390.2 - 0.077 12.7 6.3 0.023 14.4 0.9 2.5 2 1 0 2 2 2 0 AAA ATPase domain AIG1 PF04548.16 AAS51390.2 - 0.084 12.2 1.3 0.66 9.3 0.1 2.7 3 0 0 3 3 3 0 AIG1 family Ribosomal_60s PF00428.19 AAS51390.2 - 0.43 11.2 4.4 1.7 9.3 4.4 2.0 1 0 0 1 1 1 0 60s Acidic ribosomal protein Ank_2 PF12796.7 AAS51391.1 - 1.5e-11 44.7 0.1 3.9e-11 43.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 AAS51391.1 - 2.8e-11 43.3 0.1 0.00046 20.5 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 AAS51391.1 - 1.3e-10 41.6 0.1 3.9e-10 40.0 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 AAS51391.1 - 7.5e-10 38.9 0.0 1.2e-05 25.5 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) TIG PF01833.24 AAS51391.1 - 9.4e-10 38.4 0.3 5.1e-09 36.1 0.2 2.3 2 0 0 2 2 2 1 IPT/TIG domain Ank_3 PF13606.6 AAS51391.1 - 3.6e-09 36.1 0.0 0.0082 16.6 0.0 3.2 2 0 0 2 2 2 2 Ankyrin repeat RHD_dimer PF16179.5 AAS51391.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Rel homology dimerisation domain WD40 PF00400.32 AAS51392.2 - 1.7e-21 76.1 6.2 3.6e-06 27.6 0.2 5.0 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51392.2 - 1.4e-09 38.2 3.8 0.61 10.4 0.0 5.2 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 AAS51392.2 - 6.4e-06 25.2 4.2 0.92 8.2 0.0 4.7 1 1 3 5 5 5 4 Nup133 N terminal like Nup160 PF11715.8 AAS51392.2 - 0.0011 17.7 0.6 0.027 13.1 0.1 2.6 1 1 1 3 3 3 1 Nucleoporin Nup120/160 MRP-S32 PF10210.9 AAS51392.2 - 0.035 14.6 0.1 0.082 13.5 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 AlaDh_PNT_N PF05222.15 AAS51393.1 - 1.8e-32 112.5 0.0 3e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 AAS51393.1 - 0.032 13.5 0.0 0.16 11.3 0.0 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain TPR_1 PF00515.28 AAS51394.1 - 2e-40 135.0 10.5 1.5e-05 24.6 0.0 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 AAS51394.1 - 1.9e-35 118.1 7.7 0.0014 18.6 0.0 10.3 10 0 0 10 10 10 7 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS51394.1 - 2.6e-33 114.1 12.6 2.1e-25 88.7 0.0 5.5 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AAS51394.1 - 7.7e-26 88.1 8.9 0.0014 18.7 0.1 9.4 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51394.1 - 5.4e-23 81.1 6.1 7.7e-07 29.3 0.0 9.0 6 2 2 8 8 8 6 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51394.1 - 1.4e-21 76.8 0.4 0.0018 18.7 0.0 7.3 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 AAS51394.1 - 2.5e-19 68.2 5.4 0.005 17.1 0.0 9.2 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51394.1 - 4.9e-15 54.9 0.1 0.4 11.6 0.0 8.3 5 2 3 8 8 8 2 Tetratricopeptide repeat TPR_10 PF13374.6 AAS51394.1 - 1.6e-13 50.1 1.0 0.023 14.6 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 AAS51394.1 - 2.2e-13 49.6 0.3 0.45 10.2 0.0 7.0 5 2 1 6 6 6 3 TPR repeat TPR_7 PF13176.6 AAS51394.1 - 5.1e-13 48.0 6.8 0.0038 17.2 0.0 7.8 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 AAS51394.1 - 6.7e-13 48.4 8.0 0.79 10.5 0.1 9.1 10 0 0 10 10 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51394.1 - 1.4e-12 48.1 0.0 0.015 15.9 0.0 6.4 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_15 PF13429.6 AAS51394.1 - 1.6e-06 27.5 0.2 2 7.6 0.1 5.4 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_3 PF07720.12 AAS51394.1 - 3.5e-06 26.9 3.8 0.22 11.5 0.0 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 AAS51394.1 - 6.3e-06 26.2 0.0 0.23 11.6 0.0 4.3 5 0 0 5 5 4 2 Tetratricopeptide repeat ChAPs PF09295.10 AAS51394.1 - 1.5e-05 24.2 1.7 0.031 13.3 0.3 3.3 3 1 0 3 3 3 2 ChAPs (Chs5p-Arf1p-binding proteins) Fis1_TPR_C PF14853.6 AAS51394.1 - 3.3e-05 23.9 7.0 1.5 8.9 0.2 5.7 5 0 0 5 5 5 2 Fis1 C-terminal tetratricopeptide repeat SRP_TPR_like PF17004.5 AAS51394.1 - 0.00017 21.6 5.3 0.59 10.2 0.0 4.5 3 2 1 4 4 4 2 Putative TPR-like repeat TPR_MalT PF17874.1 AAS51394.1 - 0.00028 20.4 0.1 1 8.6 0.0 4.0 4 0 0 4 4 4 1 MalT-like TPR region TPR_20 PF14561.6 AAS51394.1 - 0.035 14.4 0.3 17 5.8 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 AAS51394.1 - 0.043 13.2 3.7 13 5.2 0.1 3.8 3 2 0 3 3 3 0 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 AAS51394.1 - 0.045 14.4 0.2 32 5.4 0.0 4.1 3 0 0 3 3 3 0 Sel1 repeat TPR_21 PF09976.9 AAS51394.1 - 0.3 10.8 3.1 6.6 6.4 0.0 3.9 3 2 1 4 4 4 0 Tetratricopeptide repeat-like domain ADK PF00406.22 AAS51396.1 - 5.4e-44 149.9 0.0 7.4e-44 149.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AAS51396.1 - 6.4e-34 117.3 0.0 1.1e-33 116.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS51396.1 - 8.3e-10 39.3 0.0 1.4e-09 38.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 AAS51396.1 - 2e-05 24.3 0.2 0.14 11.8 0.1 2.2 1 1 0 2 2 2 2 Thymidylate kinase AAA_33 PF13671.6 AAS51396.1 - 2.5e-05 24.4 0.0 8.9e-05 22.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AAS51396.1 - 0.023 14.0 0.4 0.05 12.9 0.0 1.8 2 1 0 2 2 2 0 Zeta toxin AAA_19 PF13245.6 AAS51396.1 - 0.064 13.6 0.0 0.14 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AAS51396.1 - 0.26 11.0 0.3 0.6 9.8 0.1 1.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein adh_short PF00106.25 AAS51397.1 - 4.1e-46 156.9 1.2 4.8e-46 156.7 1.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51397.1 - 1.5e-32 113.1 1.7 1.8e-32 112.8 1.7 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51397.1 - 1e-08 35.3 1.1 1.6e-08 34.7 1.1 1.3 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51397.1 - 0.0029 17.1 0.8 0.015 14.8 0.8 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AAS51397.1 - 0.003 17.5 3.0 0.0041 17.0 2.8 1.4 1 1 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AAS51397.1 - 0.03 13.5 0.2 0.054 12.6 0.2 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein GPI PF06560.11 AAS51397.1 - 0.15 11.3 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) Pan3_PK PF18101.1 AAS51398.1 - 1.5e-54 183.8 0.5 2e-54 183.3 0.5 1.2 1 0 0 1 1 1 1 Pan3 Pseudokinase domain Pkinase PF00069.25 AAS51398.1 - 0.00047 19.6 0.0 0.00089 18.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain TPR_2 PF07719.17 AAS51399.1 - 1.6e-07 30.9 6.5 1.9e-07 30.6 0.1 3.2 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS51399.1 - 2.4e-07 30.3 0.3 5.7e-06 25.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS51399.1 - 5.4e-06 26.2 0.4 0.00015 21.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 AAS51399.1 - 0.0011 19.0 1.6 0.0025 17.9 0.1 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51399.1 - 0.0013 19.2 1.1 0.012 16.1 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 AAS51399.1 - 0.0014 18.9 0.5 0.17 12.4 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AAS51399.1 - 0.0019 17.9 2.2 0.0026 17.4 0.3 2.1 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 AAS51399.1 - 0.0023 18.2 0.1 0.033 14.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 AAS51399.1 - 0.018 15.6 0.3 0.42 11.4 0.0 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51399.1 - 0.023 15.5 3.7 0.033 15.0 0.5 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 AAS51399.1 - 0.11 12.5 0.9 0.45 10.6 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 AAS51399.1 - 0.17 11.8 0.5 0.63 10.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51399.1 - 0.18 12.5 2.7 0.45 11.2 0.1 2.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TIP41 PF04176.13 AAS51400.1 - 8.3e-68 227.2 2.1 1.2e-67 226.7 2.1 1.2 1 0 0 1 1 1 1 TIP41-like family Evr1_Alr PF04777.13 AAS51401.1 - 1e-25 90.1 0.1 1.5e-25 89.6 0.1 1.3 1 0 0 1 1 1 1 Erv1 / Alr family G-gamma PF00631.22 AAS51402.1 - 5.9e-28 96.7 0.1 7.9e-28 96.3 0.1 1.2 1 0 0 1 1 1 1 GGL domain Tmemb_14 PF03647.13 AAS51403.1 - 1.5e-21 76.9 7.7 1.8e-21 76.7 7.7 1.1 1 0 0 1 1 1 1 Transmembrane proteins 14C Aim19 PF10315.9 AAS51403.1 - 0.019 15.3 2.6 0.035 14.4 2.6 1.5 1 1 0 1 1 1 0 Altered inheritance of mitochondria protein 19 PCI PF01399.27 AAS51405.2 - 1.2e-09 38.6 0.0 2.1e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 PCI domain NPP PF08384.10 AAS51405.2 - 0.031 14.3 0.5 0.079 13.0 0.5 1.7 1 0 0 1 1 1 0 Pro-opiomelanocortin, N-terminal region CHASE3 PF05227.13 AAS51406.2 - 0.0018 18.2 1.0 0.0033 17.3 1.0 1.3 1 0 0 1 1 1 1 CHASE3 domain MAGSP PF03082.14 AAS51406.2 - 0.0095 15.6 0.2 0.014 15.0 0.2 1.2 1 0 0 1 1 1 1 Male accessory gland secretory protein YlqD PF11068.8 AAS51406.2 - 0.083 13.3 2.5 0.2 12.0 2.5 1.6 1 0 0 1 1 1 0 YlqD protein tRNA-synt_1d PF00750.19 AAS51406.2 - 0.13 11.2 2.1 0.085 11.8 0.3 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (R) TPD52 PF04201.15 AAS51406.2 - 0.13 11.8 5.5 2 8.0 4.8 2.7 1 1 1 2 2 2 0 Tumour protein D52 family PKcGMP_CC PF16808.5 AAS51406.2 - 0.19 11.6 5.0 0.15 12.0 2.5 2.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FliE PF02049.18 AAS51406.2 - 0.28 11.4 1.8 3.5 7.8 0.2 2.5 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE SlyX PF04102.12 AAS51406.2 - 1.7 9.3 7.6 0.22 12.2 1.1 2.7 3 1 1 4 4 4 0 SlyX GPS2_interact PF15784.5 AAS51406.2 - 3.6 8.1 9.0 1.8 9.0 3.8 2.8 2 1 1 3 3 3 0 G-protein pathway suppressor 2-interacting domain V-ATPase_H_N PF03224.14 AAS51407.1 - 1.7e-72 244.4 7.3 1.7e-72 244.4 7.3 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_C PF11698.8 AAS51407.1 - 6.1e-40 136.0 2.5 6.1e-40 136.0 2.5 2.9 3 1 0 3 3 3 1 V-ATPase subunit H TetR_C_10 PF16295.5 AAS51407.1 - 0.0029 17.9 0.1 0.0079 16.5 0.1 1.7 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain Arm PF00514.23 AAS51407.1 - 0.018 15.1 0.5 1.4 9.0 0.2 2.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Mo25 PF08569.11 AAS51407.1 - 0.041 13.3 9.6 0.63 9.4 0.2 3.7 1 1 2 4 4 4 0 Mo25-like DUF2019 PF09450.10 AAS51407.1 - 0.056 13.4 0.1 1.3 9.1 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2019) PIN PF01850.21 AAS51407.1 - 0.13 12.8 3.9 4.9 7.7 0.1 3.6 3 1 1 4 4 4 0 PIN domain Tachylectin PF14517.6 AAS51407.1 - 0.13 11.7 0.1 0.21 11.1 0.1 1.2 1 0 0 1 1 1 0 Tachylectin Gln-synt_C PF00120.24 AAS51408.1 - 2.7e-20 72.7 0.0 1.5e-15 57.0 0.0 2.1 2 0 0 2 2 2 2 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AAS51408.1 - 1.9e-14 53.2 0.0 3.3e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain SLS PF14611.6 AAS51408.1 - 0.058 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Thioredoxin_4 PF13462.6 AAS51409.1 - 2.5e-06 27.8 0.0 4.4e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 AAS51409.1 - 0.24 11.5 0.0 0.39 10.8 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin domain Actin PF00022.19 AAS51410.1 - 1.6e-53 181.8 0.0 7.1e-36 123.7 0.0 2.6 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AAS51410.1 - 0.00047 19.1 0.0 0.54 9.0 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AAS51410.1 - 0.18 12.3 0.1 1 9.8 0.1 2.1 1 1 0 1 1 1 0 Cell division protein FtsA NuA4 PF09340.10 AAS51411.2 - 1e-21 76.6 1.1 1.4e-21 76.1 1.1 1.2 1 0 0 1 1 1 1 Histone acetyltransferase subunit NuA4 Prp19 PF08606.11 AAS51411.2 - 1.8 8.6 7.9 5.2 7.1 1.4 2.3 1 1 1 2 2 2 0 Prp19/Pso4-like AIM24 PF01987.17 AAS51412.2 - 2.3e-34 119.0 0.0 2.9e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 tRNA-synt_His PF13393.6 AAS51413.1 - 1.5e-39 136.1 0.1 7.7e-39 133.8 0.1 1.9 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AAS51413.1 - 4.2e-14 52.5 0.0 8.9e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain IDO PF01231.18 AAS51414.1 - 2e-146 488.2 0.0 2.3e-146 488.0 0.0 1.0 1 0 0 1 1 1 1 Indoleamine 2,3-dioxygenase HemX PF04375.14 AAS51414.1 - 0.072 12.4 0.2 0.17 11.1 0.0 1.6 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Clathrin_propel PF01394.20 AAS51414.1 - 0.11 12.9 0.0 0.22 11.9 0.0 1.5 1 0 0 1 1 1 0 Clathrin propeller repeat Cid2 PF09774.9 AAS51415.1 - 1.1e-28 100.7 0.1 1.4e-28 100.3 0.1 1.1 1 0 0 1 1 1 1 Caffeine-induced death protein 2 Lgl_C PF08596.10 AAS51416.1 - 3.3e-143 477.1 0.0 2e-142 474.6 0.0 2.0 2 1 0 2 2 2 1 Lethal giant larvae(Lgl) like, C-terminal ANAPC4_WD40 PF12894.7 AAS51416.1 - 1.3e-09 38.3 0.3 0.013 15.8 0.0 6.3 5 2 3 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS51416.1 - 0.00013 22.7 0.4 3.3 8.7 0.0 4.9 4 0 0 4 4 4 2 WD domain, G-beta repeat Frtz PF11768.8 AAS51416.1 - 0.19 10.0 0.0 0.38 9.0 0.0 1.4 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Pkinase PF00069.25 AAS51417.1 - 1.6e-59 201.4 3.0 2.5e-59 200.8 0.0 2.5 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51417.1 - 9.6e-35 120.1 0.8 2.4e-34 118.8 0.0 2.0 3 0 0 3 3 3 1 Protein tyrosine kinase HR1 PF02185.16 AAS51417.1 - 1.6e-21 76.2 27.1 9.7e-13 48.0 6.3 3.5 3 0 0 3 3 3 2 Hr1 repeat C1_1 PF00130.22 AAS51417.1 - 9.3e-19 67.1 37.2 2.5e-11 43.3 15.2 2.5 2 0 0 2 2 2 2 Phorbol esters/diacylglycerol binding domain (C1 domain) Pkinase_C PF00433.24 AAS51417.1 - 2.2e-11 44.2 0.4 9.3e-11 42.3 0.4 2.2 1 0 0 1 1 1 1 Protein kinase C terminal domain C2 PF00168.30 AAS51417.1 - 0.00032 20.9 0.4 0.00096 19.4 0.4 1.8 1 1 0 1 1 1 1 C2 domain Kinase-like PF14531.6 AAS51417.1 - 0.00059 19.2 3.0 0.017 14.4 0.0 3.0 2 1 1 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 AAS51417.1 - 0.034 12.9 0.8 0.11 11.2 0.1 2.3 2 1 0 2 2 2 0 Fungal protein kinase Uds1 PF15456.6 AAS51417.1 - 0.11 12.6 13.1 0.11 12.7 7.9 2.9 1 1 0 2 2 2 0 Up-regulated During Septation DUF745 PF05335.13 AAS51417.1 - 0.13 12.0 11.5 0.048 13.4 6.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) zf-RING_9 PF13901.6 AAS51417.1 - 8.1 6.4 34.1 0.41 10.6 8.2 3.5 3 0 0 3 3 3 0 Putative zinc-RING and/or ribbon zinc_ribbon_16 PF17034.5 AAS51418.1 - 5.1e-26 91.3 5.5 1.5e-25 89.8 5.5 1.9 1 0 0 1 1 1 1 Zinc-ribbon like family Zn_ribbon_17 PF17120.5 AAS51418.1 - 2.5e-05 23.8 7.4 2.5e-05 23.8 7.4 2.5 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AAS51418.1 - 0.0029 18.4 2.5 0.6 11.1 0.1 4.6 5 0 0 5 5 5 1 WD domain, G-beta repeat zf-HC5HC2H_2 PF13832.6 AAS51419.1 - 4.3e-30 104.1 8.0 4.3e-30 104.1 8.0 2.5 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 AAS51419.1 - 1e-27 96.2 6.4 1e-27 96.2 6.4 3.4 3 0 0 3 3 3 2 PHD-like zinc-binding domain PHD_2 PF13831.6 AAS51419.1 - 5e-14 51.6 3.6 5e-14 51.6 3.6 2.8 2 0 0 2 2 2 1 PHD-finger PHD PF00628.29 AAS51419.1 - 4.5e-11 42.5 5.2 4.5e-11 42.5 5.2 2.7 2 0 0 2 2 2 1 PHD-finger EPL1 PF10513.9 AAS51419.1 - 1.7e-10 41.5 0.0 3.4e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 Enhancer of polycomb-like Prok-RING_1 PF14446.6 AAS51419.1 - 0.018 14.9 3.7 0.018 14.9 3.7 3.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 C1_1 PF00130.22 AAS51419.1 - 0.076 12.9 0.4 0.076 12.9 0.4 2.7 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-RING-like PF08746.11 AAS51419.1 - 0.57 10.5 20.7 3.6 8.0 12.1 2.7 2 0 0 2 2 2 0 RING-like domain WD40 PF00400.32 AAS51420.1 - 1.4e-10 41.5 2.3 0.015 16.1 0.0 6.1 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51420.1 - 0.0018 18.6 0.0 11 6.4 0.0 3.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4536 PF15055.6 AAS51421.1 - 0.095 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4536) Pkinase PF00069.25 AAS51422.1 - 1.3e-65 221.4 0.0 1.9e-65 220.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51422.1 - 5.9e-39 133.9 0.0 8.6e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS51422.1 - 0.00012 21.2 0.4 0.00039 19.5 0.4 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 AAS51422.1 - 0.00017 20.5 1.0 0.00031 19.6 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 AAS51422.1 - 0.002 17.5 0.0 0.0041 16.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like DEAD PF00270.29 AAS51423.1 - 1.2e-44 152.2 0.0 1.8e-44 151.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51423.1 - 2.6e-30 105.0 0.9 7.3e-29 100.3 0.4 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Phage_integrase PF00589.22 AAS51423.1 - 0.14 12.0 0.0 0.27 11.0 0.0 1.5 1 0 0 1 1 1 0 Phage integrase family Arcadin_1 PF18653.1 AAS51423.1 - 0.17 12.0 0.8 1 9.5 0.0 2.6 3 0 0 3 3 3 0 Arcadin 1 PNP_UDP_1 PF01048.20 AAS51424.1 - 1e-41 142.8 0.1 1.2e-41 142.5 0.1 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily DUF1523 PF07509.11 AAS51424.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) WD40 PF00400.32 AAS51425.1 - 2.7e-17 62.8 19.0 0.00036 21.3 0.9 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51425.1 - 0.00011 22.5 3.6 0.64 10.4 0.4 4.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain TFIIIC_delta PF12657.7 AAS51425.1 - 0.015 15.2 2.0 0.064 13.2 2.0 2.2 1 1 0 1 1 1 0 Transcription factor IIIC subunit delta N-term BCS1_N PF08740.11 AAS51426.1 - 9.1e-49 166.0 0.1 1.2e-48 165.6 0.1 1.1 1 0 0 1 1 1 1 BCS1 N terminal AAA PF00004.29 AAS51426.1 - 1.6e-20 73.8 0.0 8.1e-20 71.6 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS51426.1 - 0.0015 18.9 0.0 0.0062 16.9 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AAS51426.1 - 0.0017 18.1 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 AAS51426.1 - 0.0022 18.5 0.0 0.0048 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AAS51426.1 - 0.0031 17.5 0.0 0.006 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.17 AAS51426.1 - 0.0083 15.9 0.2 1.7 8.3 0.0 2.3 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein AAA_7 PF12775.7 AAS51426.1 - 0.0086 15.6 0.0 0.022 14.3 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 AAS51426.1 - 0.017 14.9 0.0 0.035 13.8 0.0 1.5 2 0 0 2 2 1 0 AAA domain DUF815 PF05673.13 AAS51426.1 - 0.02 14.1 0.0 0.036 13.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_33 PF13671.6 AAS51426.1 - 0.021 15.0 0.0 0.055 13.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AAS51426.1 - 0.023 14.4 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 AAS51426.1 - 0.033 14.5 0.0 0.081 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS51426.1 - 0.045 14.3 0.0 0.086 13.4 0.0 1.5 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 AAS51426.1 - 0.049 14.0 0.0 0.11 12.9 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATPase PF06745.13 AAS51426.1 - 0.07 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 KaiC AAA_21 PF13304.6 AAS51426.1 - 0.074 12.8 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 AAS51426.1 - 0.11 12.6 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AAS51426.1 - 0.13 11.8 0.0 0.68 9.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain Rad17 PF03215.15 AAS51426.1 - 0.14 12.1 0.0 0.34 10.8 0.0 1.6 1 1 0 1 1 1 0 Rad17 P-loop domain NACHT PF05729.12 AAS51426.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 AAS51426.1 - 0.15 11.8 0.0 0.28 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AAS51426.1 - 0.17 11.9 0.0 0.35 10.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 AAS51426.1 - 0.22 11.4 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Gram_pos_anchor PF00746.21 AAS51426.1 - 0.3 11.1 3.1 0.5 10.3 0.4 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Lipase_GDSL_2 PF13472.6 AAS51427.3 - 5.1e-26 92.2 0.1 6.2e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 AAS51427.3 - 1.3e-12 48.1 0.0 1.8e-12 47.7 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Pyr_redox_2 PF07992.14 AAS51428.2 - 8.6e-09 35.0 0.0 4.1e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AAS51428.2 - 0.00018 21.7 0.0 0.001 19.3 0.0 2.2 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AAS51428.2 - 0.00043 20.3 0.0 0.0018 18.3 0.0 2.1 2 0 0 2 2 2 1 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 AAS51428.2 - 0.085 11.9 0.0 0.25 10.4 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain F1F0-ATPsyn_F PF10791.9 AAS51429.2 - 5.8e-41 138.9 0.1 6.6e-41 138.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial F1-F0 ATP synthase subunit F of fungi LSM PF01423.22 AAS51430.1 - 3.5e-18 65.1 0.0 4e-18 64.9 0.0 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AAS51430.1 - 5.5e-05 23.2 0.0 6.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AAS51430.1 - 0.0016 18.5 0.0 0.0019 18.3 0.0 1.3 1 1 0 1 1 1 1 Scd6-like Sm domain RhoGAP PF00620.27 AAS51431.1 - 3.6e-42 143.8 0.3 8.1e-42 142.6 0.1 1.7 2 0 0 2 2 2 1 RhoGAP domain LIM PF00412.22 AAS51431.1 - 1.1e-12 48.0 27.8 3.6e-06 27.1 12.0 2.5 2 0 0 2 2 2 2 LIM domain Seryl_tRNA_N PF02403.22 AAS51431.1 - 0.085 13.1 2.9 0.3 11.4 2.9 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 AAS51431.1 - 0.25 10.6 6.2 0.41 9.9 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) CoiA PF06054.11 AAS51431.1 - 1 8.5 5.1 1.6 7.8 0.4 2.1 2 0 0 2 2 2 0 Competence protein CoiA-like family DUF5082 PF16888.5 AAS51431.1 - 1.3 9.4 6.2 0.45 10.8 2.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) TSC22 PF01166.18 AAS51431.1 - 2.5 8.5 5.3 5.1 7.5 1.9 2.7 2 1 1 3 3 3 0 TSC-22/dip/bun family JIP_LZII PF16471.5 AAS51431.1 - 7.7 6.8 8.9 4 7.7 6.1 2.0 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II Complex1_LYR PF05347.15 AAS51432.1 - 4.5e-16 58.6 0.7 5.4e-16 58.4 0.7 1.1 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 AAS51432.1 - 7.3e-05 23.4 0.6 8.5e-05 23.2 0.6 1.1 1 0 0 1 1 1 1 Complex1_LYR-like Glyco_transf_21 PF13506.6 AAS51433.2 - 9.6e-23 80.5 0.1 7.7e-18 64.5 0.0 2.7 2 1 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_3 PF13641.6 AAS51433.2 - 8.7e-17 61.8 0.0 1.6e-15 57.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AAS51433.2 - 7.8e-07 29.1 0.0 1.4e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Zn_clus PF00172.18 AAS51435.2 - 6e-08 32.7 5.3 1.5e-07 31.4 5.3 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fun_ATP-synt_8 PF05933.13 AAS51435.2 - 0.25 11.5 1.7 0.59 10.3 1.7 1.6 1 0 0 1 1 1 0 Fungal ATP synthase protein 8 (A6L) AIRC PF00731.20 AAS51436.1 - 3.6e-63 211.6 1.4 6.5e-63 210.7 1.4 1.4 1 0 0 1 1 1 1 AIR carboxylase ATP-grasp PF02222.22 AAS51436.1 - 2e-59 200.0 0.0 3.1e-59 199.4 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 AAS51436.1 - 1.7e-17 62.9 0.0 3.5e-17 61.8 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain 2-Hacid_dh_C PF02826.19 AAS51436.1 - 0.00011 21.6 0.1 0.00027 20.4 0.1 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CPSase_L_D2 PF02786.17 AAS51436.1 - 0.00027 20.5 0.0 0.00044 19.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 AAS51436.1 - 0.00037 20.1 0.0 0.0022 17.5 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus AlaDh_PNT_C PF01262.21 AAS51436.1 - 0.017 14.4 0.5 0.037 13.3 0.5 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain ATP-grasp_3 PF02655.14 AAS51436.1 - 0.11 12.6 0.0 0.39 10.8 0.0 2.0 2 0 0 2 2 2 0 ATP-grasp domain TPP_enzyme_N PF02776.18 AAS51437.2 - 2e-27 95.9 0.0 3.5e-27 95.1 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS51437.2 - 3.4e-21 75.4 0.0 7.7e-21 74.3 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AAS51437.2 - 2.7e-14 53.2 0.0 5.8e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain SPA PF08616.10 AAS51438.2 - 1e-35 122.1 2.2 1.2e-35 121.8 0.6 2.0 2 0 0 2 2 2 1 Stabilization of polarity axis Afi1 PF07792.12 AAS51438.2 - 5.5e-31 107.8 0.1 2.4e-30 105.7 0.0 2.0 2 0 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking ORC4_C PF14629.6 AAS51438.2 - 1.3 8.3 5.0 1.8 7.8 1.4 2.4 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 4 C-terminus Glyco_hydro_47 PF01532.20 AAS51439.1 - 4.8e-91 305.9 0.0 5.6e-91 305.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Myb_DNA-bind_4 PF13837.6 AAS51440.1 - 4.2e-05 23.8 0.2 7.5e-05 23.0 0.2 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain DUF573 PF04504.14 AAS51440.1 - 0.063 13.9 0.2 0.15 12.7 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF573 SHMT PF00464.19 AAS51441.2 - 9.3e-206 683.1 0.0 1.1e-205 682.8 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 AAS51441.2 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AAS51441.2 - 0.00026 20.3 0.0 0.00063 19.0 0.0 1.5 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AAS51441.2 - 0.00037 19.6 0.0 0.0006 18.9 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AAS51441.2 - 0.13 11.6 0.1 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 AAS51441.2 - 0.17 10.4 0.0 0.29 9.6 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme bZIP_2 PF07716.15 AAS51442.2 - 0.00029 20.8 7.1 0.00029 20.8 7.1 1.6 1 1 1 2 2 2 1 Basic region leucine zipper bZIP_1 PF00170.21 AAS51442.2 - 0.00033 20.7 9.1 0.00055 20.0 9.1 1.3 1 0 0 1 1 1 1 bZIP transcription factor RNase_T PF00929.24 AAS51443.1 - 3.2e-31 109.1 0.0 3.9e-31 108.8 0.0 1.1 1 0 0 1 1 1 1 Exonuclease Pkinase PF00069.25 AAS51444.2 - 2.4e-58 197.6 0.1 5.8e-36 124.2 1.3 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51444.2 - 4.2e-25 88.5 0.1 8.2e-20 71.2 0.4 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AAS51444.2 - 1e-05 25.0 0.0 0.00028 20.3 0.1 2.1 1 1 1 2 2 2 2 Kinase-like Response_reg PF00072.24 AAS51444.2 - 1.2e-05 25.4 0.0 3.4e-05 24.0 0.0 1.8 1 0 0 1 1 1 1 Response regulator receiver domain Kdo PF06293.14 AAS51444.2 - 0.00076 18.9 0.1 0.0015 18.0 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS51444.2 - 0.002 18.1 0.2 0.034 14.1 0.4 2.5 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS51444.2 - 0.0063 15.5 0.1 0.0063 15.5 0.1 2.3 2 0 0 2 2 2 1 Haspin like kinase domain PAS PF00989.25 AAS51444.2 - 0.01 15.8 0.0 0.026 14.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold RIO1 PF01163.22 AAS51444.2 - 0.013 15.1 0.5 0.029 14.0 0.4 1.6 1 1 0 1 1 1 0 RIO1 family PAS_4 PF08448.10 AAS51444.2 - 0.026 14.8 0.0 0.063 13.5 0.0 1.6 1 0 0 1 1 1 0 PAS fold PAS_9 PF13426.7 AAS51444.2 - 0.061 13.6 0.0 0.16 12.2 0.0 1.7 1 0 0 1 1 1 0 PAS domain Seadorna_VP7 PF07387.11 AAS51444.2 - 0.12 11.4 2.1 0.081 12.0 0.2 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 tRNA_synthFbeta PF17759.1 AAS51445.2 - 4.4e-40 137.4 0.0 9.1e-40 136.4 0.0 1.5 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 AAS51445.2 - 3.5e-34 118.0 0.0 5.6e-34 117.3 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain PhetRS_B1 PF18262.1 AAS51445.2 - 1.1e-29 102.5 2.4 6.8e-29 99.9 0.4 2.8 2 1 0 2 2 2 1 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 AAS51445.2 - 3.3e-18 65.8 0.0 6.9e-16 58.3 0.0 2.7 2 0 0 2 2 2 1 tRNA synthetase B5 domain Herpes_V23 PF01802.17 AAS51445.2 - 0.12 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein DUF726 PF05277.12 AAS51446.1 - 1.1e-128 429.1 1.8 1.8e-128 428.3 1.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF726) DUF1761 PF08570.10 AAS51446.1 - 0.13 12.5 1.0 0.89 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1761) Ribosomal_L22e PF01776.17 AAS51447.1 - 3.2e-40 136.9 0.7 4.1e-40 136.5 0.7 1.0 1 0 0 1 1 1 1 Ribosomal L22e protein family Methyltransf_34 PF11312.8 AAS51448.1 - 3.4e-84 282.7 0.0 4.8e-84 282.2 0.0 1.2 1 0 0 1 1 1 1 Putative SAM-dependent methyltransferase Mob1_phocein PF03637.17 AAS51449.1 - 1.7e-65 220.2 1.4 2.3e-65 219.8 1.4 1.2 1 0 0 1 1 1 1 Mob1/phocein family RNA_pol PF00940.19 AAS51450.1 - 7e-176 585.1 0.1 1.2e-175 584.3 0.1 1.4 1 0 0 1 1 1 1 DNA-dependent RNA polymerase RPOL_N PF14700.6 AAS51450.1 - 2.8e-101 339.3 0.5 5.8e-101 338.2 0.5 1.6 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal AD PF09793.9 AAS51450.1 - 0.014 15.5 0.0 0.058 13.5 0.0 2.0 1 0 0 1 1 1 0 Anticodon-binding domain Tubulin PF00091.25 AAS51451.1 - 5.2e-68 229.1 0.0 8.9e-68 228.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AAS51451.1 - 1.6e-42 144.7 0.0 2.7e-42 143.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 AAS51451.1 - 0.0022 17.7 0.0 0.0039 16.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 AAS51451.1 - 0.005 16.1 0.0 0.0095 15.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 AAS51451.1 - 0.009 16.3 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Rad51 PF08423.11 AAS51452.1 - 1.5e-128 427.4 0.0 1.9e-128 427.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AAS51452.1 - 6.8e-12 45.4 0.0 9.7e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AAS51452.1 - 3.7e-10 39.7 0.0 5.4e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 AAS51452.1 - 3.3e-09 37.2 0.1 7.1e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix domain ATPase PF06745.13 AAS51452.1 - 6.8e-06 25.6 0.1 1.5e-05 24.5 0.1 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 AAS51452.1 - 0.0026 17.1 0.1 0.015 14.6 0.0 2.0 2 0 0 2 2 2 1 DnaB-like helicase C terminal domain AAA_24 PF13479.6 AAS51452.1 - 0.065 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AAS51452.1 - 0.15 12.4 0.0 0.4 11.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain HHH PF00633.23 AAS51452.1 - 0.17 11.8 0.1 0.37 10.8 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif PAXNEB PF05625.11 AAS51452.1 - 0.29 10.2 0.6 0.56 9.3 0.1 1.6 2 0 0 2 2 2 0 PAXNEB protein Sel1 PF08238.12 AAS51453.1 - 1.6e-45 152.5 14.0 2.4e-07 31.2 0.4 7.6 7 0 0 7 7 7 7 Sel1 repeat Kinesin PF00225.23 AAS51454.1 - 1e-106 356.7 1.7 1e-106 356.7 1.7 2.5 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 AAS51454.1 - 8.1e-26 90.7 0.2 8.1e-26 90.7 0.2 3.6 3 2 0 3 3 3 1 Microtubule binding Apolipoprotein PF01442.18 AAS51454.1 - 6.8e-08 32.6 1.1 6.8e-08 32.6 1.1 4.5 3 2 1 4 4 4 1 Apolipoprotein A1/A4/E domain ResIII PF04851.15 AAS51454.1 - 0.017 15.1 0.0 0.017 15.1 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit PhoH PF02562.16 AAS51454.1 - 0.051 13.0 2.1 0.34 10.3 0.1 2.9 2 1 0 3 3 3 0 PhoH-like protein DUF3153 PF11353.8 AAS51454.1 - 0.93 9.0 4.6 1.6 8.3 0.1 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3153) Baculo_PEP_C PF04513.12 AAS51454.1 - 1.9 8.5 23.9 1.5 8.9 1.0 5.3 2 2 3 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FliS PF02561.14 AAS51454.1 - 1.9 8.8 11.0 0.083 13.2 1.7 3.2 2 1 0 2 2 2 0 Flagellar protein FliS eIF3_subunit PF08597.10 AAS51455.1 - 4.1e-47 161.1 27.4 2e-46 158.9 27.4 1.8 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit Peroxin-13_N PF04088.13 AAS51456.1 - 9.3e-49 165.4 0.3 1.4e-48 164.9 0.3 1.2 1 0 0 1 1 1 1 Peroxin 13, N-terminal region SH3_1 PF00018.28 AAS51456.1 - 3.6e-09 36.1 0.0 7.3e-09 35.1 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS51456.1 - 6.1e-07 29.0 0.0 1.6e-06 27.7 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_9 PF14604.6 AAS51456.1 - 2e-06 27.5 0.0 5.3e-06 26.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 AAS51456.1 - 0.003 17.8 0.0 0.0054 17.0 0.0 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain MMR1 PF08505.10 AAS51457.1 - 9.9e-41 140.7 9.7 1.2e-40 140.5 6.2 2.6 2 1 0 2 2 2 1 Mitochondrial Myo2 receptor-related protein DUF16 PF01519.16 AAS51457.1 - 2.2 8.8 4.4 8.7 6.9 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 PALP PF00291.25 AAS51458.1 - 5e-75 252.6 0.7 6.5e-75 252.3 0.7 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Thr_dehydrat_C PF00585.18 AAS51458.1 - 9.5e-39 131.1 0.0 8.2e-25 86.4 0.0 2.5 2 0 0 2 2 2 2 C-terminal regulatory domain of Threonine dehydratase DegT_DnrJ_EryC1 PF01041.17 AAS51458.1 - 0.11 11.7 0.1 0.19 11.0 0.1 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family tRNA-synt_2b PF00587.25 AAS51459.1 - 2.2e-34 119.0 0.0 3.3e-34 118.4 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Sec61_beta PF03911.16 AAS51460.1 - 1.8e-18 66.2 0.8 2.3e-18 65.9 0.8 1.1 1 0 0 1 1 1 1 Sec61beta family Podoplanin PF05808.11 AAS51460.1 - 0.018 15.1 0.0 0.026 14.6 0.0 1.2 1 0 0 1 1 1 0 Podoplanin RRM_1 PF00076.22 AAS51461.1 - 2.5e-06 27.2 0.0 5e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_2 PF04059.12 AAS51461.1 - 0.087 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif 2 MOZ_SAS PF01853.18 AAS51462.2 - 2.9e-72 242.1 0.3 4.4e-72 241.5 0.3 1.3 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AAS51462.2 - 2e-18 65.7 8.9 2e-18 65.7 8.9 1.9 2 0 0 2 2 2 1 MYST family zinc finger domain Acetyltransf_7 PF13508.7 AAS51462.2 - 0.0037 17.7 0.0 0.0091 16.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Myb_DNA-binding PF00249.31 AAS51463.2 - 2.3e-12 46.9 9.6 5.7e-11 42.4 0.2 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS51463.2 - 4e-11 43.0 1.9 3.5e-09 36.8 0.4 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain TatD_DNase PF01026.21 AAS51464.1 - 1.3e-36 126.2 0.0 1.7e-36 125.9 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase DciA PF05258.12 AAS51464.1 - 0.058 13.8 0.3 17 5.9 0.1 2.6 2 0 0 2 2 2 0 Dna[CI] antecedent, DciA PP2C PF00481.21 AAS51465.1 - 9.5e-80 267.9 0.0 1.3e-79 267.5 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C DUF3873 PF12989.7 AAS51465.1 - 0.094 13.1 0.2 0.26 11.7 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) F-box PF00646.33 AAS51466.1 - 0.00012 21.8 0.4 0.00012 21.8 0.4 2.3 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 AAS51466.1 - 0.00053 19.8 2.4 0.0011 18.8 1.2 2.3 2 0 0 2 2 2 1 F-box-like YhdB PF14148.6 AAS51466.1 - 0.052 13.6 0.4 0.24 11.6 0.4 2.1 1 0 0 1 1 1 0 YhdB-like protein Zn_clus PF00172.18 AAS51467.2 - 3.4e-08 33.5 9.5 6.6e-08 32.5 9.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Sugar_transport PF06800.12 AAS51467.2 - 0.2 10.9 0.1 0.34 10.2 0.1 1.3 1 0 0 1 1 1 0 Sugar transport protein Las1 PF04031.13 AAS51468.1 - 8.8e-47 159.1 0.9 3.4e-46 157.1 0.1 2.1 2 0 0 2 2 2 1 Las1-like NRIP1_repr_3 PF15689.5 AAS51468.1 - 0.13 12.6 0.1 0.25 11.7 0.1 1.4 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 3 RNA_polI_A34 PF08208.11 AAS51469.1 - 2e-25 90.1 22.7 2e-25 90.1 22.7 1.8 1 1 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 Coilin_N PF15862.5 AAS51469.1 - 0.021 14.6 10.0 0.042 13.7 10.0 1.5 1 0 0 1 1 1 0 Coilin N-terminus Peptidase_S49_N PF08496.10 AAS51469.1 - 3.6 7.6 11.4 1.4 9.0 8.8 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TFA2_Winged_2 PF18121.1 AAS51470.1 - 1e-18 66.8 0.0 2.2e-18 65.7 0.0 1.6 1 0 0 1 1 1 1 TFA2 Winged helix domain 2 TFIIE_beta PF02186.15 AAS51470.1 - 3.9e-13 49.5 0.2 9.9e-13 48.2 0.2 1.7 1 0 0 1 1 1 1 TFIIE beta subunit core domain CobT PF06213.12 AAS51471.2 - 0.062 12.7 0.2 0.12 11.7 0.2 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_r3 PF04539.16 AAS51472.1 - 0.028 14.5 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-70 region 3 CRAL_TRIO PF00650.20 AAS51473.1 - 6.5e-23 81.2 0.0 9.3e-23 80.7 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AAS51473.1 - 2.6e-06 27.5 0.1 7.7e-06 26.0 0.1 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AAS51473.1 - 0.001 19.2 0.0 0.0016 18.6 0.0 1.3 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain Tim17 PF02466.19 AAS51474.1 - 1.1e-30 106.3 6.9 1.4e-30 105.9 6.9 1.2 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF3180 PF11377.8 AAS51474.1 - 9.5 6.4 9.9 6.8 6.8 0.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3180) Pkinase PF00069.25 AAS51475.1 - 5.8e-50 170.1 0.2 1.6e-49 168.7 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51475.1 - 2.2e-24 86.1 0.0 3.4e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 AAS51475.1 - 0.0027 17.3 0.0 0.0079 15.8 0.0 1.7 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 AAS51475.1 - 0.0029 17.6 0.1 0.0055 16.6 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AAS51475.1 - 0.07 12.7 2.0 0.13 11.8 0.0 2.2 2 1 0 3 3 3 0 Choline/ethanolamine kinase TPX2_importin PF12214.8 AAS51475.1 - 0.086 13.0 0.1 10 6.3 0.1 2.2 2 0 0 2 2 2 0 Cell cycle regulated microtubule associated protein RNA_pol_Rpb4 PF03874.16 AAS51476.1 - 4.4e-36 123.9 0.4 7.2e-36 123.2 0.4 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 Glyco_transf_15 PF01793.16 AAS51477.1 - 3.3e-108 361.8 0.2 4e-108 361.5 0.2 1.0 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase Ribosomal_L1 PF00687.21 AAS51478.1 - 1.4e-43 149.1 0.0 1.7e-43 148.8 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DEAD PF00270.29 AAS51479.1 - 3.4e-47 160.4 1.0 4.3e-47 160.1 0.3 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51479.1 - 1.9e-31 108.7 0.3 4.6e-30 104.2 0.1 2.7 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51479.1 - 1.3e-07 31.8 0.0 2.4e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AAS51479.1 - 0.00023 21.5 0.1 0.0048 17.2 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS51479.1 - 0.0017 18.1 0.1 0.0033 17.2 0.1 1.4 1 0 0 1 1 1 1 AAA domain UTP25 PF06862.12 AAS51479.1 - 0.011 14.5 0.2 2.3 6.9 0.0 2.3 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AAS51479.1 - 0.014 14.7 0.0 0.031 13.6 0.0 1.6 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Glyco_transf_8 PF01501.20 AAS51480.1 - 3.3e-21 76.0 0.0 1.8e-20 73.6 0.0 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 8 Ribosomal_S21e PF01249.18 AAS51481.1 - 1.5e-39 134.0 0.1 1.6e-39 133.8 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S21e Glyco_hydro2_C5 PF18565.1 AAS51481.1 - 0.048 13.5 0.0 0.057 13.3 0.0 1.2 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 tRNA_U5-meth_tr PF05958.11 AAS51482.1 - 3.6e-19 69.0 0.0 7.3e-18 64.7 0.0 2.1 1 1 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRAM PF01938.20 AAS51482.1 - 2.8e-10 40.0 0.0 5.6e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 TRAM domain Methyltransf_31 PF13847.6 AAS51482.1 - 3.1e-07 30.3 0.0 6.2e-07 29.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS51482.1 - 1.3e-06 29.0 0.0 3.7e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 AAS51482.1 - 4.8e-06 26.2 0.1 8.2e-06 25.5 0.1 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 AAS51482.1 - 4e-05 23.1 0.1 6.5e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Met_10 PF02475.16 AAS51482.1 - 0.0012 18.6 0.1 0.0053 16.5 0.0 2.1 3 0 0 3 3 3 1 Met-10+ like-protein Methyltransf_11 PF08241.12 AAS51482.1 - 0.0024 18.5 0.0 0.0069 17.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AAS51482.1 - 0.0027 17.3 0.0 0.0048 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 AAS51482.1 - 0.1 11.9 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AAS51482.1 - 0.14 11.6 0.0 0.3 10.6 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase Ras PF00071.22 AAS51483.1 - 2.9e-46 157.0 0.0 3.7e-46 156.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51483.1 - 2.9e-23 82.4 0.0 4.5e-23 81.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51483.1 - 4.3e-06 26.3 0.0 5.6e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_6 PF12774.7 AAS51484.1 - 1.8e-116 388.7 0.0 3.2e-115 384.6 0.0 3.0 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 AAS51484.1 - 4.6e-96 322.3 8.1 4.6e-96 322.3 8.1 5.4 5 1 0 5 5 2 1 Dynein heavy chain, N-terminal region 2 DHC_N1 PF08385.12 AAS51484.1 - 5e-84 282.9 18.0 5e-84 282.9 18.0 3.2 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 1 AAA_9 PF12781.7 AAS51484.1 - 8.7e-60 201.6 0.0 8.7e-60 201.6 0.0 3.9 3 0 0 3 3 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 AAS51484.1 - 9.2e-45 152.4 0.2 1.3e-38 132.3 0.0 4.2 4 0 0 4 4 3 2 P-loop containing dynein motor region AAA_8 PF12780.7 AAS51484.1 - 1.4e-44 152.4 0.1 1.3e-43 149.2 0.1 2.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 MT PF12777.7 AAS51484.1 - 3.9e-34 118.2 8.6 3.9e-34 118.2 8.6 2.0 2 0 0 2 2 1 1 Microtubule-binding stalk of dynein motor AAA_5 PF07728.14 AAS51484.1 - 2.3e-25 89.2 0.0 2.1e-09 37.5 0.0 6.0 4 1 0 4 4 4 3 AAA domain (dynein-related subfamily) AAA_lid_11 PF18198.1 AAS51484.1 - 8.4e-21 74.5 0.6 5.4e-20 71.8 0.0 2.5 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 AAS51484.1 - 2.4e-16 59.9 0.3 2.8e-15 56.4 0.0 3.1 3 0 0 3 3 1 1 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 AAS51484.1 - 3.2e-15 56.7 0.1 0.047 14.1 0.0 5.2 4 0 0 4 4 4 4 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AAS51484.1 - 1.9e-12 47.7 7.3 0.0059 16.9 0.0 7.1 7 0 0 7 7 6 4 AAA domain Dynein_AAA_lid PF17852.1 AAS51484.1 - 1.5e-09 38.0 0.5 6.3e-08 32.8 0.0 3.1 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_18 PF13238.6 AAS51484.1 - 2e-09 38.1 0.1 0.35 11.4 0.0 5.3 4 0 0 4 4 4 2 AAA domain AAA_19 PF13245.6 AAS51484.1 - 3.7e-07 30.6 1.7 0.29 11.4 0.0 4.8 4 0 0 4 4 4 2 AAA domain AAA_16 PF13191.6 AAS51484.1 - 5.3e-07 30.2 0.0 0.39 11.1 0.0 5.4 5 1 0 5 5 4 1 AAA ATPase domain T2SSE PF00437.20 AAS51484.1 - 6.5e-07 28.7 4.4 0.062 12.4 0.0 4.8 4 0 0 4 4 4 2 Type II/IV secretion system protein AAA_14 PF13173.6 AAS51484.1 - 9.6e-07 28.9 1.3 0.17 11.9 0.0 5.3 5 0 0 5 5 4 1 AAA domain ResIII PF04851.15 AAS51484.1 - 2.1e-05 24.6 0.5 0.0053 16.8 0.0 3.7 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AAS51484.1 - 2.3e-05 24.2 1.4 0.82 9.4 0.1 4.2 4 1 0 4 4 4 1 AAA domain Zeta_toxin PF06414.12 AAS51484.1 - 0.0003 20.1 0.0 0.056 12.7 0.0 3.2 3 0 0 3 3 3 1 Zeta toxin AAA_lid_1 PF17857.1 AAS51484.1 - 0.00046 20.4 0.1 0.0039 17.4 0.0 2.7 2 0 0 2 2 1 1 AAA+ lid domain AAA_33 PF13671.6 AAS51484.1 - 0.00097 19.3 0.0 2 8.6 0.0 4.4 4 0 0 4 4 4 1 AAA domain AAA_24 PF13479.6 AAS51484.1 - 0.002 17.9 4.8 1.9 8.2 0.0 4.6 5 0 0 5 5 5 1 AAA domain RNA_helicase PF00910.22 AAS51484.1 - 0.004 17.5 0.1 29 5.1 0.0 4.6 4 0 0 4 4 3 0 RNA helicase NACHT PF05729.12 AAS51484.1 - 0.0071 16.3 0.0 1.9 8.4 0.0 3.3 2 0 0 2 2 2 1 NACHT domain TsaE PF02367.17 AAS51484.1 - 0.014 15.4 0.5 1.3 9.1 0.0 3.6 4 0 0 4 4 4 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 AAS51484.1 - 0.016 15.5 0.1 54 4.0 0.0 4.3 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.6 AAS51484.1 - 0.025 14.1 0.0 2.6 7.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain cobW PF02492.19 AAS51484.1 - 0.027 14.1 0.0 2.6 7.6 0.0 3.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 AAS51484.1 - 0.028 14.7 0.1 5.5 7.2 0.0 4.2 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Torsin PF06309.11 AAS51484.1 - 0.046 13.8 0.0 0.3 11.2 0.0 2.5 1 0 0 1 1 1 0 Torsin Sigma54_activat PF00158.26 AAS51484.1 - 0.1 12.3 0.0 1.7 8.3 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain ApbE PF02424.15 AAS51484.1 - 0.13 11.7 0.3 6.6 6.2 0.1 2.5 2 0 0 2 2 2 0 ApbE family Lact-deh-memb PF09330.11 AAS51484.1 - 0.15 11.4 2.2 0.3 10.4 0.1 2.3 2 0 0 2 2 2 0 D-lactate dehydrogenase, membrane binding Mg_chelatase PF01078.21 AAS51484.1 - 0.16 11.3 0.1 5.4 6.4 0.0 3.4 4 0 0 4 4 2 0 Magnesium chelatase, subunit ChlI Ribosomal_S5_C PF03719.15 AAS51484.1 - 0.2 11.1 0.0 3.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein S5, C-terminal domain PAP2 PF01569.21 AAS51485.1 - 3.4e-16 59.2 4.8 3.4e-16 59.2 4.8 2.2 2 1 0 2 2 2 1 PAP2 superfamily LAB_N PF07578.11 AAS51485.1 - 1.4 9.1 9.6 0.81 9.8 0.6 3.2 3 0 0 3 3 3 0 Lipid A Biosynthesis N-terminal domain Mito_carr PF00153.27 AAS51486.1 - 1.1e-61 204.8 1.4 5.4e-21 74.3 0.1 3.0 2 1 1 3 3 3 3 Mitochondrial carrier protein Solute_trans_a PF03619.16 AAS51487.1 - 1.6e-73 247.5 14.8 2e-73 247.2 14.8 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha COX14 PF14880.6 AAS51487.1 - 0.055 13.3 0.0 0.055 13.3 0.0 2.0 3 0 0 3 3 3 0 Cytochrome oxidase c assembly mIF3 PF14877.6 AAS51488.1 - 8.8e-52 175.3 0.0 1.4e-51 174.7 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial translation initiation factor CPSase_L_D2 PF02786.17 AAS51489.2 - 6.9e-117 388.4 1.6 2.2e-84 282.2 0.0 2.5 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_sm_chain PF00988.22 AAS51489.2 - 5.1e-50 168.6 0.0 1.3e-49 167.2 0.0 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 AAS51489.2 - 5e-46 156.9 0.0 1.6e-45 155.2 0.0 2.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I OTCace_N PF02729.21 AAS51489.2 - 1.1e-44 152.1 0.0 2.6e-44 150.8 0.0 1.7 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain CPSase_L_D3 PF02787.19 AAS51489.2 - 5.2e-38 130.1 0.1 2.4e-37 128.0 0.1 2.2 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain OTCace PF00185.24 AAS51489.2 - 9.9e-28 97.2 0.0 1.5e-26 93.4 0.0 2.9 3 0 0 3 3 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain MGS PF02142.22 AAS51489.2 - 1.5e-21 76.4 0.0 1.1e-20 73.7 0.0 2.7 2 0 0 2 2 1 1 MGS-like domain Dala_Dala_lig_C PF07478.13 AAS51489.2 - 1.9e-17 63.5 3.4 7.5e-10 38.7 0.6 2.7 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AAS51489.2 - 2.8e-15 56.3 0.7 1.2e-07 31.5 0.2 2.6 2 0 0 2 2 2 2 ATP-grasp domain ATPgrasp_Ter PF15632.6 AAS51489.2 - 1e-11 44.7 0.1 2e-06 27.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Peptidase_C26 PF07722.13 AAS51489.2 - 3.3e-07 30.3 0.0 4.6e-05 23.3 0.0 2.8 1 1 0 1 1 1 1 Peptidase C26 ATP-grasp_3 PF02655.14 AAS51489.2 - 1.4e-05 25.2 1.2 0.034 14.2 0.2 2.9 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 AAS51489.2 - 9.7e-05 22.0 0.3 0.074 12.6 0.2 2.5 2 0 0 2 2 2 2 RimK-like ATP-grasp domain DJ-1_PfpI PF01965.24 AAS51489.2 - 0.0005 19.9 0.2 0.04 13.7 0.0 3.7 4 0 0 4 4 4 1 DJ-1/PfpI family GARS_A PF01071.19 AAS51489.2 - 0.0094 15.7 1.5 2.2 8.0 0.2 3.0 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain zf-C2H2 PF00096.26 AAS51490.1 - 8e-23 79.6 31.4 1.4e-06 28.5 0.4 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS51490.1 - 3.9e-22 77.6 27.7 4.8e-09 36.2 0.8 4.7 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS51490.1 - 4.5e-14 51.9 27.0 0.00039 21.0 0.2 4.8 4 0 0 4 4 4 4 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AAS51490.1 - 0.0039 17.1 28.6 0.016 15.2 0.6 4.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 AAS51490.1 - 0.012 15.9 9.1 0.15 12.4 0.2 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 AAS51490.1 - 0.13 12.7 16.1 9.2 6.8 0.1 4.6 4 0 0 4 4 4 0 Zinc-finger of C2H2 type DZR PF12773.7 AAS51490.1 - 0.46 10.5 6.6 3.5 7.7 6.7 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-C2H2_11 PF16622.5 AAS51490.1 - 6.5 6.6 18.5 1.1 9.1 0.3 3.9 4 0 0 4 4 4 0 zinc-finger C2H2-type TRAPP PF04051.16 AAS51491.2 - 3.7e-32 111.1 0.0 5.7e-32 110.5 0.0 1.3 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component SH3_9 PF14604.6 AAS51492.2 - 1.8e-26 91.7 0.3 2.7e-14 52.8 0.1 2.9 3 0 0 3 3 3 2 Variant SH3 domain SH3_1 PF00018.28 AAS51492.2 - 3.4e-26 90.6 0.3 6.2e-13 48.1 0.0 2.9 3 0 0 3 3 3 2 SH3 domain FCH PF00611.23 AAS51492.2 - 1.1e-17 64.1 1.4 1.8e-17 63.4 0.1 2.2 2 0 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain SH3_2 PF07653.17 AAS51492.2 - 7.7e-16 57.5 0.1 9.8e-11 41.2 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_3 PF08239.11 AAS51492.2 - 0.0008 19.6 0.7 0.013 15.8 0.0 2.4 2 0 0 2 2 2 1 Bacterial SH3 domain DUF922 PF06037.11 AAS51492.2 - 0.044 13.6 1.9 0.067 13.0 0.5 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF922) SH3_10 PF17902.1 AAS51492.2 - 0.073 13.1 0.0 18 5.5 0.1 2.6 2 0 0 2 2 2 0 SH3 domain FAM176 PF14851.6 AAS51492.2 - 0.11 12.1 4.7 0.32 10.7 4.7 1.7 1 0 0 1 1 1 0 FAM176 family TrbH PF07283.11 AAS51492.2 - 0.13 12.5 0.1 0.27 11.4 0.1 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TrbH FHA PF00498.26 AAS51493.1 - 5.8e-15 55.4 0.0 1.3e-14 54.2 0.0 1.7 1 0 0 1 1 1 1 FHA domain zf-RING_11 PF17123.5 AAS51493.1 - 6.3e-11 41.8 11.6 1.2e-10 40.9 11.6 1.5 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 AAS51493.1 - 1.3e-06 28.6 14.3 2.1e-06 28.0 14.3 1.3 1 0 0 1 1 1 1 Ring finger domain Yop-YscD_cpl PF16697.5 AAS51493.1 - 0.00023 21.4 0.0 0.00059 20.1 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-ANAPC11 PF12861.7 AAS51493.1 - 0.0078 16.3 6.2 0.015 15.3 6.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AAS51493.1 - 0.011 16.0 9.3 0.022 15.0 9.3 1.5 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 AAS51493.1 - 0.011 15.6 14.8 0.018 14.9 14.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS51493.1 - 0.011 15.6 12.2 0.018 15.0 12.2 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AAS51493.1 - 0.049 13.5 13.8 0.081 12.8 13.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Sec_GG PF07549.14 AAS51493.1 - 0.084 12.4 0.2 0.15 11.6 0.2 1.4 1 0 0 1 1 1 0 SecD/SecF GG Motif zf-RING_UBOX PF13445.6 AAS51493.1 - 0.77 9.8 12.6 1.5 8.9 12.6 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Malate_synthase PF01274.22 AAS51494.2 - 2.2e-218 725.8 0.0 2.7e-218 725.5 0.0 1.0 1 0 0 1 1 1 1 Malate synthase HpcH_HpaI PF03328.14 AAS51494.2 - 0.061 12.5 0.0 0.13 11.4 0.0 1.6 1 1 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family NMT1 PF09084.11 AAS51495.1 - 2.3e-08 34.2 0.0 6e-08 32.9 0.0 1.6 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AAS51495.1 - 3.3e-08 33.4 0.1 2.3e-07 30.7 0.0 1.9 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.6 AAS51495.1 - 1.2e-07 31.7 0.0 2e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 NMT1-like family LysR_substrate PF03466.20 AAS51495.1 - 1.9e-06 27.4 2.0 1.9e-06 27.4 2.0 2.0 2 1 0 2 2 2 1 LysR substrate binding domain DCP2 PF05026.13 AAS51496.1 - 2.3e-24 85.5 0.9 5e-24 84.4 0.9 1.6 1 0 0 1 1 1 1 Dcp2, box A domain NUDIX PF00293.28 AAS51496.1 - 1.5e-11 44.4 0.0 3.4e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain DHHA2 PF02833.14 AAS51496.1 - 0.039 14.1 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 DHHA2 domain CTU2 PF10288.9 AAS51497.1 - 8.2e-21 74.4 0.9 1.4e-20 73.6 0.2 1.8 2 0 0 2 2 2 1 Cytoplasmic tRNA 2-thiolation protein 2 Mqo PF06039.15 AAS51497.1 - 0.051 12.1 0.0 0.11 11.0 0.0 1.5 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) zinc_ribbon_15 PF17032.5 AAS51497.1 - 7.2 7.4 9.3 1.5 9.6 2.1 2.7 2 1 0 2 2 2 0 zinc-ribbon family RRM_1 PF00076.22 AAS51500.1 - 6.6e-20 70.7 0.4 3.3e-14 52.5 0.0 4.2 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS51500.1 - 0.00024 21.2 2.0 0.22 11.7 0.0 3.3 3 1 0 3 3 3 2 RNA recognition motif Spo7_2_N PF15407.6 AAS51500.1 - 0.0098 15.5 0.0 0.038 13.6 0.0 2.0 1 0 0 1 1 1 1 Sporulation protein family 7 PAD_M PF08527.10 AAS51500.1 - 0.065 12.9 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain Fur_reg_FbpB PF13040.6 AAS51500.1 - 0.18 11.4 0.0 0.18 11.4 0.0 3.0 3 0 0 3 3 3 0 Fur-regulated basic protein B SNARE PF05739.19 AAS51501.1 - 3.7e-05 23.6 2.8 7.4e-05 22.7 2.8 1.5 1 0 0 1 1 1 1 SNARE domain FGase PF05013.12 AAS51501.1 - 0.056 13.6 0.7 6.4 6.9 0.2 2.2 1 1 1 2 2 2 0 N-formylglutamate amidohydrolase PMC2NT PF08066.12 AAS51501.1 - 0.18 12.5 2.0 3.2 8.5 0.1 2.5 2 0 0 2 2 2 0 PMC2NT (NUC016) domain Exo_endo_phos PF03372.23 AAS51503.2 - 1.1e-09 38.2 0.0 3.4e-09 36.6 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Phenyl_P_gamma PF09662.10 AAS51503.2 - 0.08 13.1 0.1 0.18 12.0 0.1 1.5 1 0 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) HhH-GPD PF00730.25 AAS51504.1 - 8.7e-20 71.2 0.0 2.2e-19 69.9 0.0 1.7 2 0 0 2 2 2 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AAS51504.1 - 0.042 13.7 0.0 0.099 12.6 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif OmpW PF03922.14 AAS51504.1 - 0.055 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 OmpW family HEAT PF02985.22 AAS51505.1 - 8.1e-40 131.4 20.9 0.0036 17.4 0.0 13.0 13 0 0 13 13 13 10 HEAT repeat HEAT_2 PF13646.6 AAS51505.1 - 2.8e-31 107.8 1.0 1.2e-09 38.5 0.0 8.1 3 3 6 9 9 9 8 HEAT repeats Vac14_Fab1_bd PF12755.7 AAS51505.1 - 5.3e-14 52.6 3.8 0.16 12.6 0.0 8.4 3 3 6 9 9 9 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 AAS51505.1 - 1.9e-11 44.2 10.1 1.5 9.4 0.1 9.1 9 1 0 10 10 10 4 HEAT-like repeat Cnd1 PF12717.7 AAS51505.1 - 4.7e-10 39.7 14.9 0.00043 20.3 0.2 6.4 1 1 4 6 6 6 5 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 AAS51505.1 - 2.4e-08 33.0 5.3 0.15 10.6 0.1 4.2 1 1 3 4 4 4 4 Adaptin N terminal region API5 PF05918.11 AAS51505.1 - 0.0025 16.7 5.5 0.017 13.9 0.3 3.9 4 1 1 5 5 5 1 Apoptosis inhibitory protein 5 (API5) M11L PF11099.8 AAS51505.1 - 0.02 15.2 1.9 0.93 9.8 0.1 3.1 2 1 1 3 3 3 0 Apoptosis regulator M11L like Phosphonate-bd PF12974.7 AAS51505.1 - 0.097 12.2 0.0 0.29 10.7 0.0 1.8 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein Pkinase PF00069.25 AAS51507.2 - 2.3e-61 207.5 0.0 4.7e-61 206.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51507.2 - 1.2e-23 83.7 0.0 2e-23 83.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51507.2 - 9.1e-09 35.0 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AAS51507.2 - 0.00026 21.0 0.0 0.00048 20.1 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 AAS51507.2 - 0.00069 19.0 0.0 0.0019 17.6 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AAS51507.2 - 0.0052 15.6 0.4 0.0099 14.7 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 AAS51507.2 - 0.006 16.2 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 RIO1 family EI24 PF07264.11 AAS51508.2 - 0.03 14.6 18.2 0.086 13.1 18.2 1.8 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) G0-G1_switch_2 PF15103.6 AAS51508.2 - 0.35 11.3 0.1 0.35 11.3 0.1 2.4 1 1 1 2 2 2 0 G0/G1 switch protein 2 LsmAD PF06741.13 AAS51508.2 - 0.58 10.8 7.8 0.2 12.2 1.0 2.4 2 0 0 2 2 2 0 LsmAD domain EI24 PF07264.11 AAS51509.1 - 4.9e-06 26.9 18.6 7.2e-06 26.4 18.6 1.1 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) GSH_synth_ATP PF03917.17 AAS51510.1 - 4.2e-124 414.1 0.0 4.9e-124 413.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 AAS51510.1 - 6.1e-30 103.7 0.2 1e-29 103.0 0.2 1.4 1 0 0 1 1 1 1 Eukaryotic glutathione synthase Med15_fungi PF05397.12 AAS51511.2 - 1.5e-35 121.9 7.4 1.5e-35 121.9 7.4 10.9 7 2 4 11 11 11 1 Mediator complex subunit 15 SNF2_N PF00176.23 AAS51512.1 - 5.1e-56 189.9 0.7 9.7e-56 189.0 0.2 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS51512.1 - 1.2e-20 73.9 0.0 4.4e-18 65.7 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51512.1 - 1e-12 48.4 0.0 1.8e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS51512.1 - 4.3e-08 33.1 0.0 1.4e-07 31.4 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AAS51512.1 - 3.5e-05 23.1 0.0 0.00024 20.4 0.0 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SWI2_SNF2 PF18766.1 AAS51512.1 - 0.00016 21.4 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase RCC1 PF00415.18 AAS51513.2 - 3.9e-29 101.0 16.1 3.6e-08 33.9 0.0 7.3 7 1 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AAS51513.2 - 8.5e-20 70.0 27.0 4.4e-07 29.5 0.2 7.0 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat Exo_endo_phos PF03372.23 AAS51514.1 - 2.8e-22 79.4 0.0 4.6e-22 78.7 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family LRR_8 PF13855.6 AAS51514.1 - 2.2e-14 53.0 20.9 8.2e-07 28.7 1.3 2.7 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 AAS51514.1 - 1.5e-07 31.6 14.6 4.3e-06 27.0 1.4 3.2 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 AAS51514.1 - 0.0019 18.5 6.6 0.62 10.8 0.1 4.3 4 0 0 4 4 4 2 Leucine Rich Repeat RsmF_methylt_CI PF17126.5 AAS51514.1 - 0.044 13.8 0.1 0.65 10.1 0.0 2.7 3 0 0 3 3 3 0 RsmF rRNA methyltransferase first C-terminal domain LRR_6 PF13516.6 AAS51514.1 - 1.4 9.1 3.6 3.1 8.1 0.3 2.5 2 0 0 2 2 2 0 Leucine Rich repeat Nucleoside_tran PF01733.18 AAS51515.1 - 6.6e-39 134.1 24.8 7.2e-23 81.4 9.9 2.4 1 1 0 2 2 2 2 Nucleoside transporter PMT PF02366.18 AAS51516.1 - 3.1e-89 298.8 15.2 3.1e-89 298.8 15.2 1.9 2 1 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AAS51516.1 - 1.5e-61 207.5 13.2 1.5e-61 207.5 13.2 2.3 2 1 0 2 2 2 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AAS51516.1 - 2.5e-23 82.9 0.0 4.2e-23 82.2 0.0 1.2 1 0 0 1 1 1 1 MIR domain LDB19 PF13002.7 AAS51517.1 - 1.7e-62 210.6 0.0 2.7e-62 209.9 0.0 1.3 1 0 0 1 1 1 1 Arrestin_N terminal like Arrestin_N PF00339.29 AAS51517.1 - 0.025 14.6 0.0 0.051 13.6 0.0 1.4 1 0 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain RasGEF PF00617.19 AAS51518.1 - 3.3e-39 134.9 5.8 4.4e-39 134.5 4.0 2.3 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 AAS51518.1 - 1.5e-13 50.9 0.0 1.1e-12 48.1 0.0 2.6 2 0 0 2 2 2 1 RasGEF N-terminal motif TauD PF02668.16 AAS51519.2 - 6.5e-49 167.1 1.7 7.8e-49 166.9 1.7 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF2427 PF10348.9 AAS51520.1 - 0.11 12.2 10.3 0.35 10.7 10.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) OPT PF03169.15 AAS51521.1 - 6.5e-143 477.6 40.4 7.5e-143 477.4 40.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.6 AAS51521.1 - 0.0086 16.3 0.2 0.0086 16.3 0.2 3.9 3 0 0 3 3 3 1 Protein of unknown function (DUF4064) DUF4191 PF13829.6 AAS51521.1 - 0.33 10.3 0.9 1.1 8.5 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF983 PF06170.12 AAS51521.1 - 3.1 8.3 13.9 0.086 13.3 5.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF983) HSP20 PF00011.21 AAS51523.1 - 6.8e-21 74.3 0.4 8.9e-21 74.0 0.4 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AAS51523.1 - 1.8e-06 27.4 0.0 2.7e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA NAP PF00956.18 AAS51524.1 - 5.5e-05 22.5 0.5 0.0048 16.1 0.0 2.8 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) SUI1 PF01253.22 AAS51525.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AAS51525.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Homeodomain PF00046.29 AAS51526.3 - 2.2e-16 59.4 2.0 2.9e-16 59.1 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AAS51526.3 - 3.3e-06 26.9 0.8 5.7e-06 26.1 0.3 1.7 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 AAS51526.3 - 0.033 14.1 0.0 0.064 13.1 0.0 1.5 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PaaX_C PF08223.11 AAS51527.1 - 0.063 13.6 0.1 0.091 13.0 0.1 1.3 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Arnt_C PF18583.1 AAS51527.1 - 0.14 11.8 0.3 0.24 11.0 0.3 1.4 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain Metallophos PF00149.28 AAS51528.1 - 4.9e-11 43.5 0.7 8.7e-11 42.7 0.7 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ribosomal_S4e PF00900.20 AAS51529.1 - 2.7e-38 129.7 0.7 1.5e-37 127.3 1.0 1.9 2 0 0 2 2 2 1 Ribosomal family S4e 40S_S4_C PF16121.5 AAS51529.1 - 9.2e-26 89.2 0.1 1.8e-25 88.3 0.1 1.5 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus RS4NT PF08071.12 AAS51529.1 - 8e-20 70.7 6.9 2.4e-19 69.2 6.9 1.9 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 AAS51529.1 - 1e-08 34.7 0.6 2e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 AAS51529.1 - 1.1e-05 25.1 1.5 1.1e-05 25.1 1.5 3.2 4 0 0 4 4 4 1 KOW motif Sipho_tail PF05709.11 AAS51529.1 - 0.14 11.6 0.3 0.33 10.3 0.3 1.7 1 1 0 1 1 1 0 Phage tail protein Glyco_hydro_47 PF01532.20 AAS51530.2 - 7.6e-112 374.5 0.2 9.2e-112 374.2 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.25 AAS51531.1 - 1.7e-66 224.3 0.0 2.4e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51531.1 - 1.1e-30 106.9 0.0 1.9e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 AAS51531.1 - 2e-12 47.3 0.4 1.3e-07 31.9 0.1 2.7 1 1 1 2 2 2 2 C2 domain Pkinase_C PF00433.24 AAS51531.1 - 7.4e-10 39.4 7.0 8.7e-10 39.2 3.6 2.7 2 1 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 AAS51531.1 - 2.3e-09 37.0 0.0 1.2e-08 34.6 0.0 1.9 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 AAS51531.1 - 0.0019 17.2 1.0 0.0036 16.3 0.0 2.0 2 1 0 2 2 2 1 Haspin like kinase domain FTA2 PF13095.6 AAS51531.1 - 0.014 15.1 0.1 0.48 10.0 0.1 2.4 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 YrbL-PhoP_reg PF10707.9 AAS51531.1 - 0.032 13.8 0.0 0.077 12.5 0.0 1.6 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL HSF_DNA-bind PF00447.17 AAS51532.1 - 1.9e-31 108.5 3.3 1.9e-31 108.5 3.3 1.7 2 0 0 2 2 1 1 HSF-type DNA-binding Response_reg PF00072.24 AAS51532.1 - 5.1e-29 100.7 0.3 1.5e-28 99.2 0.3 1.9 1 0 0 1 1 1 1 Response regulator receiver domain HALZ PF02183.18 AAS51532.1 - 0.0037 17.4 2.7 0.0038 17.4 0.8 1.9 1 1 1 2 2 2 1 Homeobox associated leucine zipper bZIP_1 PF00170.21 AAS51532.1 - 0.0046 17.0 1.6 0.011 15.8 1.6 1.7 1 0 0 1 1 1 1 bZIP transcription factor Ets PF00178.22 AAS51532.1 - 0.012 16.1 1.1 0.027 14.9 0.0 2.1 2 0 0 2 2 2 0 Ets-domain SHE3 PF17078.5 AAS51532.1 - 0.02 14.6 3.6 0.034 13.8 3.6 1.3 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DivIC PF04977.15 AAS51532.1 - 0.03 14.1 0.7 0.059 13.1 0.7 1.5 1 0 0 1 1 1 0 Septum formation initiator NRBF2 PF08961.10 AAS51532.1 - 0.03 13.9 0.7 0.054 13.1 0.7 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator 3HCDH_RFF PF18321.1 AAS51532.1 - 0.043 14.3 0.0 0.11 13.0 0.0 1.7 1 0 0 1 1 1 0 3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold domain KASH_CCD PF14662.6 AAS51532.1 - 0.045 13.6 5.1 0.073 12.9 5.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF4472 PF14739.6 AAS51532.1 - 0.068 13.9 1.7 0.13 13.0 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) TACC_C PF05010.14 AAS51532.1 - 0.12 12.2 2.4 0.2 11.4 2.4 1.3 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal QRPTase_C PF01729.19 AAS51532.1 - 0.15 11.9 0.0 0.3 10.9 0.0 1.5 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain ZapB PF06005.12 AAS51532.1 - 0.27 11.7 2.8 0.57 10.7 1.8 2.0 1 1 1 2 2 2 0 Cell division protein ZapB YabA PF06156.13 AAS51532.1 - 0.29 11.8 3.5 1.1 10.0 2.9 2.0 1 1 1 2 2 2 0 Initiation control protein YabA SET PF00856.28 AAS51533.2 - 1.2e-13 51.8 0.5 5.1e-13 49.8 0.5 2.1 1 1 0 1 1 1 1 SET domain DZR PF12773.7 AAS51533.2 - 0.21 11.6 6.9 0.2 11.7 2.8 2.5 2 0 0 2 2 2 0 Double zinc ribbon DUF2318 PF10080.9 AAS51533.2 - 0.65 10.2 4.1 2.4 8.3 1.4 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2318) GST_C_3 PF14497.6 AAS51534.1 - 0.13 12.5 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain 5-FTHF_cyc-lig PF01812.20 AAS51535.1 - 2.4e-38 131.8 0.0 2.8e-38 131.6 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Aminotran_4 PF01063.19 AAS51536.1 - 3.1e-34 118.8 0.0 3.7e-34 118.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV WD40 PF00400.32 AAS51537.1 - 0.012 16.5 1.0 0.49 11.3 0.0 3.7 3 1 0 3 3 3 0 WD domain, G-beta repeat Ras PF00071.22 AAS51538.1 - 0.015 14.9 0.0 0.9 9.1 0.0 2.6 3 0 0 3 3 3 0 Ras family AAA_28 PF13521.6 AAS51538.1 - 0.077 13.2 0.6 0.25 11.6 0.2 2.0 1 1 1 2 2 2 0 AAA domain Pox_A32 PF04665.12 AAS51538.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein Atg14 PF10186.9 AAS51539.1 - 6.5e-11 41.9 2.5 2.3e-09 36.8 2.5 2.1 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ATP-synt_ab PF00006.25 AAS51540.1 - 1.2e-66 224.4 0.0 1.8e-66 223.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AAS51540.1 - 6.7e-15 55.4 1.2 1.4e-14 54.4 1.2 1.6 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Glyco_transf_20 PF00982.21 AAS51542.1 - 4.1e-200 665.4 0.0 4.8e-200 665.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 20 Glyco_trans_1_4 PF13692.6 AAS51542.1 - 4.7e-05 23.8 0.0 0.00068 20.1 0.0 2.6 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 AAS51542.1 - 0.00014 21.5 1.9 0.011 15.3 0.1 3.3 3 1 0 3 3 3 1 Glycosyl transferases group 1 Glyco_transf_5 PF08323.11 AAS51542.1 - 0.0091 15.7 0.5 0.02 14.6 0.1 1.7 2 0 0 2 2 2 1 Starch synthase catalytic domain PP2C PF00481.21 AAS51543.2 - 1.6e-61 208.2 0.8 5.3e-60 203.2 0.0 2.8 2 1 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 AAS51543.2 - 0.013 15.4 0.5 2.7 7.8 0.0 2.5 3 0 0 3 3 3 0 Stage II sporulation protein E (SpoIIE) Tau95 PF09734.9 AAS51544.2 - 1.7e-30 106.7 0.7 1.7e-30 106.7 0.7 1.8 2 0 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Tau95_N PF17682.1 AAS51544.2 - 7.4e-24 84.4 0.0 1.4e-23 83.5 0.0 1.5 1 0 0 1 1 1 1 Tau95 Triple barrel domain Ribosomal_L31 PF01197.18 AAS51545.1 - 0.0081 16.4 0.0 0.015 15.5 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L31 Me-amine-dh_H PF06433.11 AAS51545.1 - 0.055 12.3 0.0 0.071 12.0 0.0 1.2 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) DIM1 PF02966.16 AAS51546.1 - 5.5e-67 223.6 0.7 6.2e-67 223.4 0.7 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 DUF3192 PF11399.8 AAS51546.1 - 0.0062 16.5 0.1 0.0091 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3192) Thioredoxin PF00085.20 AAS51546.1 - 0.01 15.8 0.1 0.014 15.4 0.1 1.2 1 0 0 1 1 1 0 Thioredoxin HGTP_anticodon PF03129.20 AAS51547.1 - 1.2e-20 73.5 0.1 2.5e-20 72.4 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AAS51547.1 - 3.9e-08 33.5 0.0 3.4e-07 30.4 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF1732 PF08340.11 AAS51547.1 - 0.13 12.2 0.2 14 5.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1732) Leptin PF02024.15 AAS51548.1 - 0.075 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Leptin RRM_1 PF00076.22 AAS51549.2 - 6.2e-10 38.8 0.2 2.4e-06 27.3 0.1 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP_EFTU PF00009.27 AAS51550.1 - 3.5e-55 186.6 0.0 5.1e-55 186.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AAS51550.1 - 7.4e-41 139.0 0.0 1.7e-40 137.8 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AAS51550.1 - 6.1e-15 55.4 1.7 6.1e-15 55.4 1.7 2.3 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS51550.1 - 0.00043 20.3 0.2 0.011 15.8 0.2 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 AAS51550.1 - 0.028 14.3 0.8 0.028 14.3 0.8 2.0 3 0 0 3 3 3 0 Elongation factor Tu domain 4 CIMR PF00878.18 AAS51551.1 - 8.9e-09 35.6 0.0 0.0034 17.4 0.0 2.3 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat FixQ PF05545.11 AAS51553.2 - 0.051 13.6 0.2 0.12 12.4 0.2 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Syndecan PF01034.20 AAS51553.2 - 0.49 10.3 4.4 2 8.4 0.1 2.9 2 1 1 3 3 3 0 Syndecan domain Transketolase_N PF00456.21 AAS51554.1 - 4.7e-160 532.0 0.0 8e-160 531.3 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transket_pyr PF02779.24 AAS51554.1 - 7.3e-46 156.1 0.0 1.4e-45 155.2 0.0 1.4 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AAS51554.1 - 2e-11 43.8 0.0 4.2e-11 42.8 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain DXP_synthase_N PF13292.6 AAS51554.1 - 0.0099 15.1 0.0 0.1 11.8 0.0 2.2 1 1 0 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 AAS51554.1 - 0.063 12.2 0.0 0.17 10.8 0.0 1.6 2 0 0 2 2 2 0 Dehydrogenase E1 component TPP_enzyme_N PF02776.18 AAS51554.1 - 0.072 12.7 0.0 2.8 7.5 0.0 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain XFP_C PF09363.10 AAS51554.1 - 0.13 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 XFP C-terminal domain LMWPc PF01451.21 AAS51555.1 - 7.4e-50 169.0 0.0 8.3e-50 168.9 0.0 1.0 1 0 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Not3 PF04065.15 AAS51556.1 - 7.6e-65 218.6 31.7 1.9e-48 164.9 21.4 2.3 1 1 1 2 2 2 2 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 AAS51556.1 - 2.8e-38 131.0 0.5 2.8e-38 131.0 0.5 2.1 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family CoA_transf_3 PF02515.17 AAS51556.1 - 0.16 11.0 2.5 0.3 10.1 0.2 2.0 1 1 1 2 2 2 0 CoA-transferase family III L31 PF09784.9 AAS51556.1 - 0.76 10.2 6.3 9.2 6.7 6.3 2.5 1 1 0 1 1 1 0 Mitochondrial ribosomal protein L31 Erythro_esteras PF05139.14 AAS51556.1 - 1.2 8.9 4.4 4.7 6.9 4.4 1.9 1 1 0 1 1 1 0 Erythromycin esterase PE_PPE_C PF12484.8 AAS51557.2 - 0.012 16.6 4.3 0.014 16.3 3.0 1.8 1 1 0 1 1 1 0 Polymorphic PE/PPE proteins C terminal ORC6 PF05460.13 AAS51557.2 - 0.031 13.5 1.4 0.038 13.3 1.4 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2046 PF09755.9 AAS51557.2 - 0.08 12.2 0.3 0.11 11.7 0.3 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Acid_PPase PF12689.7 AAS51558.2 - 2.1e-43 148.1 0.0 2.6e-43 147.8 0.0 1.1 1 0 0 1 1 1 1 Acid Phosphatase Ish1 PF10281.9 AAS51559.1 - 3.8e-35 119.9 34.6 3.4e-11 43.3 0.5 7.5 7 0 0 7 7 7 6 Putative stress-responsive nuclear envelope protein SAP PF02037.27 AAS51559.1 - 3.4e-07 29.9 0.0 1 9.2 0.0 5.6 5 0 0 5 5 5 2 SAP domain HeH PF12949.7 AAS51559.1 - 0.00031 20.4 0.0 0.5 10.1 0.0 3.8 5 0 0 5 5 5 2 HeH/LEM domain DUF883 PF05957.13 AAS51559.1 - 0.14 12.8 18.2 0.27 11.9 0.1 5.3 4 1 2 6 6 6 0 Bacterial protein of unknown function (DUF883) Slx4 PF09494.10 AAS51559.1 - 0.26 11.3 0.9 36 4.4 0.1 4.5 4 1 0 4 4 4 0 Slx4 endonuclease Phasin_2 PF09361.10 AAS51559.1 - 0.51 10.6 7.8 6.3 7.1 0.0 3.9 4 0 0 4 4 4 0 Phasin protein Uds1 PF15456.6 AAS51559.1 - 0.79 9.9 4.4 2.1 8.5 1.0 2.5 2 0 0 2 2 2 0 Up-regulated During Septation AAA_15 PF13175.6 AAS51559.1 - 1.7 8.3 8.2 0.32 10.7 3.5 2.0 2 0 0 2 2 2 0 AAA ATPase domain Choline_kinase PF01633.20 AAS51559.1 - 1.8 8.1 5.2 1.5 8.3 3.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase RPM2 PF08579.11 AAS51562.2 - 8e-55 184.4 0.2 5.3e-54 181.7 0.2 2.5 1 0 0 1 1 1 1 Mitochondrial ribonuclease P subunit (RPM2) PPR_2 PF13041.6 AAS51562.2 - 0.021 15.0 0.0 13 6.0 0.0 3.8 3 0 0 3 3 3 0 PPR repeat family PPR_3 PF13812.6 AAS51562.2 - 1.3 9.1 6.6 2.6 8.2 0.3 3.7 4 0 0 4 4 4 0 Pentatricopeptide repeat domain HMG_CoA_synt_C PF08540.10 AAS51563.1 - 2.2e-111 372.0 0.9 2.8e-111 371.6 0.9 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 AAS51563.1 - 7.6e-95 315.7 0.2 1.1e-94 315.2 0.2 1.2 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal zf-CCCH PF00642.24 AAS51564.2 - 5.3e-09 35.8 6.7 8e-07 28.8 1.7 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AAS51564.2 - 1.9e-08 34.0 5.4 1.2e-05 25.2 0.8 2.4 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 AAS51564.2 - 0.0001 23.0 1.9 0.018 15.8 0.2 2.4 2 0 0 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 AAS51564.2 - 0.0062 16.3 10.5 0.015 15.1 0.4 2.7 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 AAS51564.2 - 0.0069 16.6 1.8 0.49 10.6 0.3 2.4 2 0 0 2 2 2 2 Zinc-finger containing family RRM_1 PF00076.22 AAS51564.2 - 0.007 16.2 0.0 0.012 15.5 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_2 PF14608.6 AAS51564.2 - 0.3 11.6 7.1 0.7 10.5 0.7 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Proteasome PF00227.26 AAS51565.1 - 2.5e-59 200.0 0.0 3.1e-59 199.6 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS51565.1 - 2.3e-09 36.8 0.7 5e-09 35.7 0.1 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature Utp14 PF04615.13 AAS51566.1 - 8e-190 633.1 69.8 8e-190 633.1 69.8 2.1 1 1 1 2 2 2 1 Utp14 protein Leucyl-specific PF14795.6 AAS51566.1 - 7.9 6.6 6.3 0.77 9.9 0.2 2.6 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain Prefoldin PF02996.17 AAS51567.2 - 7.6e-27 93.6 4.4 7.6e-27 93.6 4.4 1.3 1 1 0 1 1 1 1 Prefoldin subunit GIT_CC PF16559.5 AAS51567.2 - 0.031 14.1 5.3 1.6 8.6 0.7 2.6 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4241 PF14025.6 AAS51567.2 - 0.12 12.7 0.7 0.18 12.1 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4241) IL11 PF07400.11 AAS51567.2 - 0.13 11.9 0.1 0.13 11.9 0.1 2.0 2 0 0 2 2 2 0 Interleukin 11 SYCE1 PF15233.6 AAS51567.2 - 0.3 11.1 11.9 0.66 10.0 6.4 2.1 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 PHM7_cyt PF14703.6 AAS51567.2 - 0.38 10.9 11.3 1.2 9.3 11.3 1.8 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter LMBR1 PF04791.16 AAS51567.2 - 1.6 7.5 5.9 2.1 7.2 5.9 1.2 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF2935 PF11155.8 AAS51567.2 - 3.6 7.9 8.4 5.9 7.2 4.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) COG2 PF06148.11 AAS51567.2 - 6.2 6.9 9.2 4.2 7.5 0.4 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Rad10 PF03834.14 AAS51568.1 - 1.8e-37 127.8 0.0 2.4e-37 127.4 0.0 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) TORC_N PF12884.7 AAS51568.1 - 0.051 14.4 0.1 0.31 11.8 0.0 2.1 2 1 0 2 2 2 0 Transducer of regulated CREB activity, N terminus Asn_synthase PF00733.21 AAS51569.2 - 2.3e-20 73.6 0.4 5e-12 46.1 0.1 2.6 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AAS51569.2 - 2.6e-11 43.5 2.0 4e-09 36.4 0.1 3.9 4 1 0 4 4 4 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AAS51569.2 - 2.9e-08 34.0 0.0 2.8e-06 27.6 0.0 2.7 2 1 0 2 2 2 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AAS51569.2 - 0.0042 16.6 0.0 0.024 14.1 0.0 1.9 2 0 0 2 2 2 1 Aluminium induced protein tRNA_Me_trans PF03054.16 AAS51569.2 - 0.012 14.5 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase VPS9 PF02204.18 AAS51570.1 - 1.9e-26 92.3 0.0 3.3e-26 91.5 0.0 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain CUE PF02845.16 AAS51570.1 - 1.2e-10 40.8 0.0 2.3e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 CUE domain DUF5601 PF18151.1 AAS51570.1 - 2.6e-08 34.1 0.0 5.2e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5601) ERO1 PF04137.15 AAS51571.2 - 5.9e-123 410.6 0.1 9e-123 409.9 0.1 1.3 1 0 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) PP_kinase_N PF13089.6 AAS51571.2 - 0.011 16.1 0.6 0.064 13.6 0.1 2.5 2 0 0 2 2 2 0 Polyphosphate kinase N-terminal domain TFIID-18kDa PF02269.16 AAS51572.1 - 9e-30 102.6 0.0 1.3e-29 102.0 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit Histone PF00125.24 AAS51572.1 - 0.013 15.9 0.3 0.037 14.4 0.0 1.9 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AAS51572.1 - 0.053 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 TATA box binding protein associated factor (TAF) NAD_binding_4 PF07993.12 AAS51573.2 - 2.9e-73 246.2 0.0 5.1e-73 245.4 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein AMP-binding PF00501.28 AAS51573.2 - 2.7e-65 220.6 0.0 3.6e-65 220.2 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme PP-binding PF00550.25 AAS51573.2 - 5.3e-12 45.9 0.0 1.1e-11 44.9 0.0 1.6 1 0 0 1 1 1 1 Phosphopantetheine attachment site Epimerase PF01370.21 AAS51573.2 - 4.6e-11 42.6 0.0 9e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AAS51573.2 - 1.2e-05 24.5 0.0 8.4e-05 21.7 0.0 2.1 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 AAS51573.2 - 0.0059 16.0 0.0 0.01 15.3 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 AAS51573.2 - 0.0081 15.3 0.0 0.014 14.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein AMP-binding_C PF13193.6 AAS51573.2 - 0.021 15.8 0.0 0.075 14.0 0.0 2.0 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain Nop52 PF05997.12 AAS51573.2 - 0.055 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 Nucleolar protein,Nop52 RAP PF08373.10 AAS51573.2 - 0.16 12.1 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 RAP domain RELT PF12606.8 AAS51573.2 - 0.19 10.7 0.4 0.54 9.3 0.4 1.7 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 SNF2_N PF00176.23 AAS51574.2 - 6.3e-51 173.1 0.0 1.9e-50 171.5 0.0 1.8 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS51574.2 - 6.6e-15 55.4 0.0 2.4e-14 53.6 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4 PF00097.25 AAS51574.2 - 1.2e-08 34.7 5.8 1.2e-08 34.7 5.8 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ResIII PF04851.15 AAS51574.2 - 6.7e-08 32.7 0.0 1.1e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS51574.2 - 2e-06 27.7 0.0 4e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase zf-C3HC4_2 PF13923.6 AAS51574.2 - 3.2e-05 23.7 5.6 3.2e-05 23.7 5.6 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) SWI2_SNF2 PF18766.1 AAS51574.2 - 0.00093 18.9 0.0 0.0015 18.3 0.0 1.2 1 0 0 1 1 1 1 SWI2/SNF2 ATPase zf-C3HC4_3 PF13920.6 AAS51574.2 - 0.0011 18.8 6.3 0.0011 18.8 6.3 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS51574.2 - 0.0023 18.2 7.3 0.0023 18.2 7.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 AAS51574.2 - 0.023 15.0 3.2 0.056 13.7 3.2 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_Tnp_IS91 PF14319.6 AAS51574.2 - 0.062 13.3 10.4 0.61 10.2 2.1 2.4 2 0 0 2 2 2 0 Transposase zinc-binding domain zf-Nse PF11789.8 AAS51574.2 - 0.47 10.3 3.8 1.1 9.1 3.8 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 AAS51574.2 - 9.5 6.2 16.1 0.036 13.9 6.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 TPR_1 PF00515.28 AAS51575.2 - 1.7e-50 166.9 15.8 2.4e-07 30.3 0.0 10.0 9 1 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 AAS51575.2 - 1.9e-43 143.1 21.0 0.00015 21.7 0.0 9.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 AAS51575.2 - 2.3e-31 105.9 20.8 0.00018 21.6 0.1 11.4 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 AAS51575.2 - 3.7e-29 98.5 11.7 0.11 12.8 0.0 10.1 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51575.2 - 9.6e-23 80.6 21.0 3.1e-05 24.5 0.2 6.6 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 AAS51575.2 - 2.7e-22 78.1 22.9 4.8e-05 23.0 0.0 9.7 4 2 6 10 10 10 5 TPR repeat TPR_14 PF13428.6 AAS51575.2 - 5.2e-22 76.6 24.2 0.0039 17.9 0.0 10.2 4 3 6 10 10 10 8 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51575.2 - 4.1e-19 68.8 18.1 0.00056 20.4 2.0 7.0 3 3 4 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 AAS51575.2 - 6e-18 63.5 22.5 0.0016 18.3 0.4 9.0 8 1 1 9 9 9 5 Tetratricopeptide repeat TPR_6 PF13174.6 AAS51575.2 - 1.1e-17 63.4 15.8 0.78 10.5 0.0 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_9 PF13371.6 AAS51575.2 - 5.3e-17 61.7 20.5 0.00017 21.7 0.1 6.1 2 2 3 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51575.2 - 1.2e-16 60.8 33.3 0.00033 20.9 0.2 8.3 4 2 3 7 7 7 6 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS51575.2 - 6.8e-12 45.4 7.9 5.3e-05 23.4 0.2 3.7 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 AAS51575.2 - 1.1e-09 38.0 12.7 0.0022 17.2 0.2 5.1 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 AAS51575.2 - 3.2e-06 26.8 19.4 0.069 13.1 0.5 7.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_MalT PF17874.1 AAS51575.2 - 0.00021 20.8 8.3 0.037 13.4 0.3 4.4 3 1 2 5 5 5 2 MalT-like TPR region TPR_21 PF09976.9 AAS51575.2 - 0.0024 17.6 6.2 1 9.0 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat-like domain ChAPs PF09295.10 AAS51575.2 - 0.021 13.8 0.6 1.1 8.2 0.1 2.5 2 1 1 3 3 3 0 ChAPs (Chs5p-Arf1p-binding proteins) Mcm10 PF09332.11 AAS51575.2 - 0.083 12.3 6.3 0.26 10.7 6.3 1.9 1 0 0 1 1 1 0 Mcm10 replication factor RPN7 PF10602.9 AAS51575.2 - 0.71 9.6 6.7 13 5.4 0.0 4.6 5 1 1 6 6 6 0 26S proteasome subunit RPN7 NARP1 PF12569.8 AAS51575.2 - 0.92 8.3 7.2 1.3 7.9 0.0 3.8 4 1 1 5 5 5 0 NMDA receptor-regulated protein 1 EnY2 PF10163.9 AAS51576.1 - 1.5e-26 92.5 1.3 1.8e-26 92.3 1.3 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 Rep_fac_C PF08542.11 AAS51576.1 - 0.03 14.7 1.0 0.046 14.1 1.0 1.4 1 1 0 1 1 1 0 Replication factor C C-terminal domain USP8_interact PF08941.10 AAS51576.1 - 0.055 13.3 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 USP8 interacting ECH_2 PF16113.5 AAS51576.1 - 0.063 12.8 0.6 0.07 12.6 0.6 1.0 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase COMPASS-Shg1 PF05205.12 AAS51576.1 - 0.097 13.4 1.6 0.4 11.4 0.9 2.0 1 1 1 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 DEP PF00610.21 AAS51576.1 - 0.13 12.4 0.0 0.33 11.0 0.0 1.7 2 1 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NUDIX PF00293.28 AAS51577.1 - 1.3e-18 67.3 0.1 1.4e-17 64.0 0.0 2.0 2 0 0 2 2 2 1 NUDIX domain Med1 PF10744.9 AAS51578.1 - 1.9e-26 93.1 1.9 2.6e-23 82.8 0.7 2.1 1 1 1 2 2 2 2 Mediator of RNA polymerase II transcription subunit 1 Spermine_synth PF01564.17 AAS51579.2 - 8.4e-73 243.8 0.0 1.4e-72 243.1 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 AAS51579.2 - 4.6e-24 84.1 0.0 8e-24 83.3 0.0 1.4 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_25 PF13649.6 AAS51579.2 - 0.00025 21.7 0.0 0.0005 20.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS51579.2 - 0.0016 19.1 0.0 0.0035 18.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain GAT PF03127.14 AAS51579.2 - 0.0089 16.3 0.0 2.4 8.5 0.0 2.5 2 0 0 2 2 2 2 GAT domain MTS PF05175.14 AAS51579.2 - 0.079 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Hist_deacetyl PF00850.19 AAS51580.2 - 8.4e-71 239.0 0.4 1.1e-70 238.6 0.4 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Glyco_trans_4_4 PF13579.6 AAS51581.2 - 1.2e-09 38.8 0.6 2.8e-09 37.6 0.6 1.6 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glycos_transf_1 PF00534.20 AAS51581.2 - 2.1e-07 30.6 0.0 2.9e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AAS51581.2 - 2.2e-06 27.8 0.3 3.8e-06 27.0 0.3 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AAS51581.2 - 0.0006 20.3 0.0 0.0013 19.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 AAS51581.2 - 0.023 15.1 0.0 0.051 14.0 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 EF-hand_1 PF00036.32 AAS51582.1 - 5.9e-30 100.6 3.5 2e-08 33.2 0.0 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AAS51582.1 - 3.7e-26 91.4 0.2 1.4e-13 51.1 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS51582.1 - 2.2e-25 86.4 2.7 5.5e-08 32.1 0.0 4.4 4 1 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AAS51582.1 - 2e-17 61.8 3.7 4.9e-07 29.0 0.0 4.2 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 AAS51582.1 - 8e-16 57.6 4.6 2.8e-07 30.3 0.0 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 AAS51582.1 - 1.6e-12 47.6 0.0 1.5e-08 34.8 0.0 2.1 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 AAS51582.1 - 5.6e-06 26.6 0.1 0.0044 17.3 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 AAS51582.1 - 1.5e-05 25.2 0.1 0.25 11.7 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain UPF0154 PF03672.13 AAS51582.1 - 0.00031 20.7 0.0 0.3 11.1 0.0 3.1 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0154) Dockerin_1 PF00404.18 AAS51582.1 - 0.005 17.0 0.2 1.3 9.3 0.1 2.5 1 1 2 3 3 3 2 Dockerin type I domain EF-hand_4 PF12763.7 AAS51582.1 - 0.0066 16.4 0.2 0.02 14.9 0.1 1.7 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand DUF3349 PF11829.8 AAS51582.1 - 0.0067 17.2 0.5 4.8 8.0 0.0 2.7 1 1 2 3 3 3 1 Protein of unknown function (DUF3349) Caleosin PF05042.13 AAS51582.1 - 0.0075 16.2 0.0 1.9 8.4 0.0 2.7 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 AAS51582.1 - 0.0075 16.2 0.1 0.15 12.0 0.0 2.2 2 1 0 2 2 2 1 Tellurite resistance protein TerB DUF853 PF05872.12 AAS51582.1 - 0.015 13.9 0.2 0.043 12.4 0.2 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SurA_N_3 PF13624.6 AAS51582.1 - 0.049 13.4 0.4 1.2 8.9 0.1 2.0 1 1 1 2 2 2 0 SurA N-terminal domain RNA_pol_Rpb4 PF03874.16 AAS51582.1 - 0.056 13.8 1.0 0.7 10.2 0.1 2.5 2 1 1 3 3 3 0 RNA polymerase Rpb4 Glycos_trans_3N PF02885.17 AAS51582.1 - 0.087 12.7 3.8 3.2 7.7 0.1 3.4 1 1 1 3 3 3 0 Glycosyl transferase family, helical bundle domain GPHH PF16905.5 AAS51582.1 - 0.088 12.6 0.0 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated AIM3 PF17096.5 AAS51584.2 - 1.1e-23 84.0 4.2 1.1e-23 84.0 4.2 4.9 4 2 1 5 5 5 1 Altered inheritance of mitochondria protein 3 ArgoMid PF16487.5 AAS51585.1 - 0.11 12.8 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Mid domain of argonaute PAW PF04721.17 AAS51585.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 PNGase C-terminal domain, mannose-binding module PAW DUF2947 PF11163.8 AAS51585.1 - 0.18 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Fe-S_biosyn PF01521.20 AAS51586.1 - 8.8e-11 42.0 0.0 3.4e-10 40.1 0.0 1.8 1 1 0 1 1 1 1 Iron-sulphur cluster biosynthesis ThiF PF00899.21 AAS51587.1 - 1.9e-56 191.2 0.0 2.3e-56 190.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 AAS51587.1 - 0.051 13.6 0.0 0.19 11.8 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 AAS51587.1 - 0.2 12.2 0.0 0.33 11.5 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pho88 PF10032.9 AAS51588.2 - 5.9e-79 263.6 0.2 6.5e-79 263.4 0.2 1.0 1 0 0 1 1 1 1 Phosphate transport (Pho88) SID PF11778.8 AAS51588.2 - 0.0081 16.3 1.4 0.089 12.9 0.1 2.6 1 1 1 2 2 2 1 Septation initiation HMG_box PF00505.19 AAS51589.1 - 2.9e-13 50.0 7.2 9.1e-13 48.4 7.2 1.9 1 1 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS51589.1 - 5e-09 36.6 1.6 1.4e-08 35.2 1.6 1.7 1 0 0 1 1 1 1 HMG-box domain DUF1525 PF07511.11 AAS51589.1 - 6.2 7.0 11.6 13 6.0 11.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) Vac_ImportDeg PF09783.9 AAS51590.2 - 3.2e-59 199.4 0.0 3.7e-59 199.1 0.0 1.0 1 0 0 1 1 1 1 Vacuolar import and degradation protein UPF0139 PF03669.13 AAS51591.2 - 0.00035 20.4 0.4 0.00061 19.6 0.4 1.3 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0139) dCMP_cyt_deam_1 PF00383.23 AAS51592.2 - 4.6e-20 71.4 0.0 7.4e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AAS51592.2 - 1.3e-16 60.6 0.0 1.5e-16 60.4 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 AAS51592.2 - 0.0015 18.6 0.0 0.0034 17.5 0.0 1.6 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 AAS51592.2 - 0.0018 18.4 0.0 0.03 14.4 0.0 2.1 2 0 0 2 2 2 1 Novel AID APOBEC clade 1 Bd3614-deam PF14439.6 AAS51592.2 - 0.002 18.2 0.6 0.01 15.9 0.9 2.0 1 1 1 2 2 2 1 Bd3614-like deaminase APOBEC2 PF18772.1 AAS51592.2 - 0.0029 17.7 0.0 0.046 13.8 0.0 2.0 2 0 0 2 2 2 1 APOBEC2 APOBEC_N PF08210.11 AAS51592.2 - 0.028 14.3 0.0 0.32 10.9 0.0 2.0 2 0 0 2 2 2 0 APOBEC-like N-terminal domain NAD2 PF18782.1 AAS51592.2 - 0.038 14.1 0.0 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Novel AID APOBEC clade 2 DnaJ PF00226.31 AAS51593.1 - 7.8e-16 58.0 0.0 1.2e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 DnaJ domain SIP1 PF04938.12 AAS51595.1 - 5.4e-08 32.8 0.0 3.2e-07 30.3 0.0 2.0 1 1 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Ribonuc_2-5A PF06479.12 AAS51595.1 - 0.18 12.0 0.7 25 5.0 0.0 2.7 1 1 1 2 2 2 0 Ribonuclease 2-5A zf-C2H2_jaz PF12171.8 AAS51596.1 - 0.0016 18.7 1.9 0.0049 17.1 0.2 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AAS51596.1 - 0.42 11.1 0.3 0.42 11.1 0.3 2.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf_UBZ PF18439.1 AAS51596.1 - 3.6 7.2 9.2 6.9 6.4 0.2 3.4 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger Tfb4 PF03850.14 AAS51597.1 - 1.7e-109 365.6 0.1 2e-109 365.3 0.1 1.0 1 0 0 1 1 1 1 Transcription factor Tfb4 Rad50_zn_hook PF04423.14 AAS51597.1 - 0.02 14.7 1.3 0.051 13.4 0.2 2.2 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF4704 PF15787.5 AAS51597.1 - 0.051 12.8 0.0 0.069 12.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4704) WD40 PF00400.32 AAS51598.2 - 6.2e-25 87.0 10.6 9.2e-06 26.3 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51598.2 - 8.9e-15 54.8 4.2 1.6e-06 28.3 0.1 5.2 4 3 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 AAS51598.2 - 6.5e-10 38.6 1.2 8.5e-08 31.9 0.3 2.4 2 0 0 2 2 2 2 LisH WD40_like PF17005.5 AAS51598.2 - 1.2e-07 31.4 0.0 3.8e-05 23.2 0.0 2.6 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 AAS51598.2 - 0.00017 20.4 0.5 0.079 11.6 0.0 3.2 3 0 0 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 AAS51598.2 - 0.0002 21.3 0.2 0.0066 16.3 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Exo84_C PF16528.5 AAS51599.2 - 1.2e-57 195.1 4.6 1.2e-57 195.1 4.6 2.3 2 0 0 2 2 2 1 Exocyst component 84 C-terminal Vps51 PF08700.11 AAS51599.2 - 2.2e-15 56.5 2.6 7.8e-15 54.7 2.6 2.1 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 AAS51599.2 - 3.9e-05 23.8 1.9 0.00031 20.9 0.5 2.7 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 APG6_N PF17675.1 AAS51599.2 - 0.0001 22.9 6.0 0.00064 20.3 3.6 2.4 2 0 0 2 2 2 1 Apg6 coiled-coil region COG5 PF10392.9 AAS51599.2 - 0.00065 19.9 2.1 0.00065 19.9 2.1 3.4 2 1 1 3 3 3 1 Golgi transport complex subunit 5 T3SS_basalb_I PF17001.5 AAS51599.2 - 0.021 15.4 1.0 0.064 13.8 0.1 2.3 2 0 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI L27 PF02828.16 AAS51599.2 - 0.11 12.3 0.0 0.65 9.8 0.0 2.4 1 0 0 1 1 1 0 L27 domain Exonuc_VII_L PF02601.15 AAS51599.2 - 0.55 9.8 11.3 0.12 12.0 1.1 2.4 2 1 0 2 2 2 0 Exonuclease VII, large subunit Fzo_mitofusin PF04799.13 AAS51599.2 - 5.5 6.5 10.2 0.9 9.1 3.9 2.7 3 0 0 3 3 3 0 fzo-like conserved region Occludin_ELL PF07303.13 AAS51599.2 - 9 7.1 9.2 0.28 11.9 0.7 2.9 4 1 0 4 4 4 0 Occludin homology domain UFD1 PF03152.14 AAS51600.1 - 1.3e-09 37.8 0.0 0.0015 18.0 0.0 2.7 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 AZUL PF16558.5 AAS51600.1 - 2.8e-06 27.5 0.6 2.8e-06 27.5 0.6 3.3 4 0 0 4 4 4 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A DUF4880 PF16220.5 AAS51600.1 - 0.4 10.6 2.2 0.69 9.9 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4880) Fes1 PF08609.10 AAS51601.1 - 6.2e-24 84.7 5.2 2.3e-23 82.8 0.4 2.8 3 0 0 3 3 2 1 Nucleotide exchange factor Fes1 SIL1 PF16782.5 AAS51601.1 - 1.5e-05 24.4 0.7 2.8e-05 23.5 0.7 1.4 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 Atx10homo_assoc PF09759.9 AAS51601.1 - 0.0002 21.4 1.2 0.012 15.6 0.0 3.1 3 1 1 4 4 4 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 AAS51601.1 - 0.0006 19.9 0.7 0.0014 18.7 0.7 1.6 1 0 0 1 1 1 1 V-ATPase subunit H HEAT_2 PF13646.6 AAS51601.1 - 0.001 19.4 0.1 0.0063 16.9 0.0 2.4 2 2 0 2 2 2 1 HEAT repeats Neurochondrin PF05536.11 AAS51601.1 - 0.0028 16.1 0.1 0.0038 15.7 0.1 1.2 1 0 0 1 1 1 1 Neurochondrin V-ATPase_H_N PF03224.14 AAS51601.1 - 0.0028 17.0 0.3 0.0037 16.6 0.3 1.2 1 0 0 1 1 1 1 V-ATPase subunit H RICTOR_V PF14668.6 AAS51601.1 - 0.0043 17.3 0.0 0.011 15.9 0.0 1.8 2 0 0 2 2 1 1 Rapamycin-insensitive companion of mTOR, domain 5 DUF5578 PF17741.1 AAS51601.1 - 0.0045 16.5 0.1 0.082 12.3 0.0 2.2 1 1 1 2 2 2 1 Family of unknown function (DUF5578) Arm PF00514.23 AAS51601.1 - 0.0046 16.9 0.0 0.1 12.6 0.0 2.9 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 AAS51601.1 - 0.0051 17.0 0.0 0.81 10.1 0.0 3.2 2 0 0 2 2 2 1 HEAT repeat Rcd1 PF04078.13 AAS51601.1 - 0.0063 15.8 0.2 0.017 14.5 0.2 1.7 1 1 0 1 1 1 1 Cell differentiation family, Rcd1-like HEAT_EZ PF13513.6 AAS51601.1 - 0.019 15.5 0.0 0.094 13.2 0.0 2.3 1 1 0 1 1 1 0 HEAT-like repeat DUF3361 PF11841.8 AAS51601.1 - 0.023 14.6 2.1 0.2 11.6 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) DUF4704 PF15787.5 AAS51601.1 - 0.1 11.8 0.2 0.22 10.8 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4704) NopRA1 PF16201.5 AAS51601.1 - 0.16 11.6 0.6 26 4.3 0.0 2.8 2 1 1 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 ERCC4 PF02732.15 AAS51602.2 - 3.6e-19 69.5 0.5 6.6e-19 68.6 0.4 1.5 1 1 0 1 1 1 1 ERCC4 domain HALZ PF02183.18 AAS51602.2 - 0.011 16.0 1.8 5.3 7.4 0.2 2.7 2 0 0 2 2 2 0 Homeobox associated leucine zipper ABC_tran_CTD PF16326.5 AAS51602.2 - 0.099 12.9 2.8 0.63 10.3 0.5 2.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain Sec8_exocyst PF04048.14 AAS51603.2 - 9.9e-52 174.6 0.7 9.9e-52 174.6 0.7 3.5 2 1 1 3 3 3 1 Sec8 exocyst complex component specific domain DUF2451 PF10474.9 AAS51603.2 - 1.1e-05 25.4 2.2 1.1e-05 25.4 2.2 3.8 3 1 1 4 4 4 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 AAS51603.2 - 2.8e-05 23.6 1.6 2.8e-05 23.6 1.6 3.0 2 1 1 3 3 3 1 Vacuolar-sorting protein 54, of GARP complex Apolipoprotein PF01442.18 AAS51603.2 - 0.31 10.9 5.7 10 5.9 0.0 3.2 3 1 0 3 3 3 0 Apolipoprotein A1/A4/E domain Pkinase PF00069.25 AAS51604.2 - 3.8e-23 82.2 0.0 7.7e-23 81.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51604.2 - 2.2e-10 40.3 0.0 4.3e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase HEAT PF02985.22 AAS51604.2 - 1.5e-08 34.2 3.8 0.58 10.6 0.0 5.7 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 AAS51604.2 - 2.2e-06 28.0 0.0 0.045 14.2 0.0 3.5 2 1 1 3 3 3 2 HEAT repeats Kinase-like PF14531.6 AAS51604.2 - 0.00071 19.0 0.0 0.0034 16.7 0.0 1.9 1 1 1 2 2 2 1 Kinase-like WD40 PF00400.32 AAS51604.2 - 0.0053 17.6 1.3 10 7.2 0.0 4.2 4 0 0 4 4 4 2 WD domain, G-beta repeat APH PF01636.23 AAS51604.2 - 0.043 13.7 0.0 0.078 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 AAS51605.1 - 5.9e-63 212.7 0.0 7.7e-63 212.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51605.1 - 8.3e-30 103.9 0.0 1.2e-29 103.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS51605.1 - 0.0017 17.4 0.1 0.0023 16.9 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AAS51605.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like 4HBT_2 PF13279.6 AAS51606.1 - 1.8e-10 41.3 0.1 2.5e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily DUF1488 PF07369.11 AAS51606.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) RXT2_N PF08595.11 AAS51607.1 - 3e-38 131.3 0.1 3e-38 131.3 0.1 2.1 3 0 0 3 3 3 1 RXT2-like, N-terminal TTL PF03133.15 AAS51608.2 - 1.3e-76 257.5 1.3 1.7e-76 257.2 1.3 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family SurE PF01975.17 AAS51608.2 - 2.8e-42 144.7 0.0 4.8e-42 143.9 0.0 1.3 1 0 0 1 1 1 1 Survival protein SurE ATPgrasp_YheCD PF14398.6 AAS51608.2 - 2.5e-05 23.7 0.0 0.0025 17.1 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 AAS51608.2 - 0.0092 15.3 0.0 0.96 8.6 0.0 2.2 2 0 0 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_4 PF13535.6 AAS51608.2 - 0.058 13.0 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GA PF01468.17 AAS51608.2 - 0.066 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 GA module zf-Tim10_DDP PF02953.15 AAS51609.2 - 5.9e-12 45.1 0.0 7.8e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger HMG_box PF00505.19 AAS51610.1 - 2.4e-26 91.9 0.9 2.4e-26 91.9 0.9 1.6 2 0 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS51610.1 - 3e-19 69.4 1.3 3e-19 69.4 1.3 1.4 2 0 0 2 2 2 1 HMG-box domain Ccdc124 PF06244.12 AAS51610.1 - 0.00032 21.2 2.1 0.00055 20.5 0.0 1.9 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 124 /Oxs1 CHDNT PF08073.12 AAS51610.1 - 0.0092 15.9 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 CHDNT (NUC034) domain YABBY PF04690.13 AAS51610.1 - 0.085 13.4 0.6 0.085 13.4 0.6 1.4 1 1 0 1 1 1 0 YABBY protein PCNA_N PF00705.18 AAS51611.2 - 1.9e-49 166.6 1.6 3.3e-49 165.8 0.8 1.7 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AAS51611.2 - 6e-48 162.2 0.3 1.2e-46 158.1 0.1 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 AAS51611.2 - 1e-06 28.0 0.2 4.1e-05 22.8 0.2 2.0 1 1 1 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AAS51611.2 - 0.0016 18.0 0.0 0.0019 17.7 0.0 1.1 1 0 0 1 1 1 1 Rad9 FOP_dimer PF09398.10 AAS51611.2 - 0.033 14.4 0.2 0.074 13.3 0.2 1.5 1 0 0 1 1 1 0 FOP N terminal dimerisation domain LmjF365940-deam PF14421.6 AAS51611.2 - 0.088 12.4 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 A distinct subfamily of CDD/CDA-like deaminases Acetyltransf_1 PF00583.25 AAS51612.1 - 2.8e-18 66.2 0.1 3.5e-18 65.9 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS51612.1 - 3.2e-12 46.7 0.1 4.2e-12 46.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AAS51612.1 - 8.8e-12 45.1 0.1 1.2e-11 44.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AAS51612.1 - 9.6e-09 35.1 0.1 1.4e-08 34.5 0.1 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 AAS51612.1 - 9.1e-06 25.4 0.1 1.4e-05 24.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AAS51612.1 - 0.00025 21.1 0.1 0.001 19.1 0.0 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AAS51612.1 - 0.00034 20.7 0.1 0.00057 20.0 0.1 1.5 1 1 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 AAS51612.1 - 0.0017 19.0 0.0 0.002 18.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AAS51612.1 - 0.0039 17.3 0.1 0.0047 17.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 AAS51612.1 - 0.013 14.9 0.0 0.038 13.4 0.0 1.7 1 1 0 1 1 1 0 Putative acetyl-transferase KduI PF04962.12 AAS51612.1 - 0.05 12.9 0.0 0.064 12.6 0.0 1.1 1 0 0 1 1 1 0 KduI/IolB family ATG11 PF10377.9 AAS51613.1 - 2e-39 134.6 4.2 2.3e-39 134.4 0.0 2.7 2 1 0 2 2 2 1 Autophagy-related protein 11 MscS_porin PF12795.7 AAS51613.1 - 0.0037 16.8 15.0 0.0037 16.8 15.0 3.5 4 0 0 4 4 4 1 Mechanosensitive ion channel porin domain Fmp27_SW PF10305.9 AAS51613.1 - 0.083 13.6 2.2 0.18 12.6 0.1 2.7 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain Lebercilin PF15619.6 AAS51613.1 - 1.9 8.1 40.5 0.78 9.4 1.5 3.9 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4140 PF13600.6 AAS51613.1 - 4.6 7.7 11.2 0.75 10.3 3.4 3.7 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DHHA1 PF02272.19 AAS51613.1 - 7.3 7.0 10.8 0.93 9.9 3.8 3.0 3 0 0 3 3 3 0 DHHA1 domain FAD_binding_1 PF00667.20 AAS51614.1 - 1.1e-28 100.4 0.0 2e-28 99.5 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Flavodoxin_1 PF00258.25 AAS51614.1 - 1.3e-20 74.0 0.0 4.1e-20 72.5 0.0 1.8 2 0 0 2 2 2 1 Flavodoxin NAD_binding_1 PF00175.21 AAS51614.1 - 1.1e-13 51.8 0.0 2e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain tRNA-synt_2d PF01409.20 AAS51615.2 - 1.3e-44 152.5 0.1 8.4e-25 87.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 AAS51615.2 - 1.1e-25 89.8 0.5 3.6e-25 88.2 0.1 2.1 2 0 0 2 2 2 1 Ferredoxin-fold anticodon binding domain Ribosomal_L16 PF00252.18 AAS51616.1 - 2.4e-33 114.9 0.2 3.2e-33 114.5 0.2 1.2 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DNA_pol3_delta2 PF13177.6 AAS51617.1 - 2.9e-10 40.2 0.6 2e-09 37.4 0.6 2.1 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 AAS51617.1 - 7.1e-05 23.2 0.1 0.00017 22.0 0.1 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 AAS51617.1 - 0.0071 16.7 0.0 0.019 15.4 0.0 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain FtsK_SpoIIIE PF01580.18 AAS51617.1 - 0.019 14.3 0.2 0.062 12.6 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_assoc_2 PF16193.5 AAS51617.1 - 0.03 14.6 0.1 0.1 13.0 0.0 1.9 2 0 0 2 2 2 0 AAA C-terminal domain AAA_16 PF13191.6 AAS51617.1 - 0.032 14.6 0.0 0.077 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain DNA_pol3_delta PF06144.13 AAS51617.1 - 0.046 13.5 0.0 0.48 10.2 0.0 2.3 2 1 0 2 2 2 0 DNA polymerase III, delta subunit RuvB_N PF05496.12 AAS51617.1 - 0.053 13.3 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 AAS51617.1 - 0.061 13.2 0.0 0.087 12.7 0.0 1.4 1 1 0 1 1 1 0 Rad17 P-loop domain CobA_CobO_BtuR PF02572.15 AAS51617.1 - 0.084 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP T2SSE PF00437.20 AAS51617.1 - 0.094 11.8 0.2 4.5 6.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein Adaptin_N PF01602.20 AAS51618.1 - 1.8e-83 280.9 8.9 2.3e-83 280.5 8.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 AAS51618.1 - 9.6e-09 35.4 0.0 2e-08 34.4 0.0 1.5 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain B2-adapt-app_C PF09066.10 AAS51618.1 - 0.011 15.8 0.1 0.024 14.7 0.1 1.6 1 0 0 1 1 1 0 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 AAS51618.1 - 0.018 15.4 0.1 0.083 13.3 0.1 2.2 1 0 0 1 1 1 0 HEAT repeats Ala_racemase_N PF01168.20 AAS51619.1 - 4.1e-22 78.9 0.1 4.9e-22 78.7 0.1 1.0 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain Anoctamin PF04547.12 AAS51620.1 - 1.1e-42 146.4 26.9 5.1e-42 144.3 26.9 1.8 1 1 0 1 1 1 1 Calcium-activated chloride channel Pol_alpha_B_N PF08418.10 AAS51621.2 - 3e-51 174.8 0.0 4.6e-51 174.2 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DNA_pol_E_B PF04042.16 AAS51621.2 - 5e-44 150.2 0.2 7e-44 149.7 0.2 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B CLASP_N PF12348.8 AAS51622.2 - 2.4e-65 220.3 4.5 4.6e-65 219.4 1.6 2.9 3 0 0 3 3 3 1 CLASP N terminal Como_LCP PF02247.16 AAS51623.1 - 0.027 13.1 0.0 0.032 12.9 0.0 1.1 1 0 0 1 1 1 0 Large coat protein GTP_cyclohydro2 PF00925.20 AAS51624.1 - 1.3e-56 190.7 0.0 1.9e-56 190.1 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II RNase_PH PF01138.21 AAS51625.1 - 1.4e-09 38.6 0.2 2e-09 38.0 0.2 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AAS51625.1 - 1.5e-05 25.0 0.0 3e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 SpoU_methylase PF00588.19 AAS51626.2 - 2.3e-24 86.2 0.1 6.7e-24 84.7 0.0 1.9 2 0 0 2 2 2 1 SpoU rRNA Methylase family PX PF00787.24 AAS51627.1 - 5.4e-22 77.9 0.0 1.3e-21 76.7 0.0 1.6 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AAS51627.1 - 0.0043 16.6 9.3 0.014 14.9 1.0 2.2 2 0 0 2 2 2 2 Vps5 C terminal like Halogen_Hydrol PF10112.9 AAS51627.1 - 0.39 10.7 3.6 0.73 9.8 0.6 2.3 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein adh_short PF00106.25 AAS51628.1 - 4e-35 121.1 0.0 2.9e-34 118.2 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51628.1 - 3.6e-19 69.3 0.0 1.7e-18 67.0 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51628.1 - 1.2e-07 31.8 0.0 1.8e-06 28.0 0.0 2.1 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 AAS51628.1 - 0.0022 17.5 0.0 0.0031 17.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 AAS51628.1 - 0.19 10.7 0.1 0.27 10.2 0.1 1.3 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 AAS51628.1 - 0.2 10.8 0.0 0.35 10.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein AXE1 PF05448.12 AAS51628.1 - 0.23 10.1 0.0 0.33 9.6 0.0 1.2 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Iwr1 PF08574.10 AAS51629.2 - 2.1e-14 54.2 11.9 2.1e-14 54.2 11.9 2.5 3 0 0 3 3 3 1 Transcription factor Iwr1 Ribosomal_L6 PF00347.23 AAS51630.1 - 2.2e-31 108.4 10.8 1.2e-17 64.3 4.4 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 SLS PF14611.6 AAS51630.1 - 0.021 14.7 0.9 0.042 13.7 0.9 1.7 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Nup84_Nup100 PF04121.13 AAS51631.1 - 3.1e-182 607.5 7.0 3.7e-182 607.2 7.0 1.0 1 0 0 1 1 1 1 Nuclear pore protein 84 / 107 SH3_1 PF00018.28 AAS51632.1 - 3e-08 33.1 0.2 5e-07 29.2 0.1 2.4 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 AAS51632.1 - 8.6e-05 22.3 0.1 0.00025 20.8 0.1 1.9 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS51632.1 - 0.00049 19.7 1.1 0.00065 19.3 0.1 1.8 2 0 0 2 2 2 1 Variant SH3 domain Acetyltransf_2 PF00797.17 AAS51632.1 - 0.15 11.8 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 N-acetyltransferase Chorismate_synt PF01264.21 AAS51633.2 - 2.4e-139 463.6 0.0 2.7e-139 463.4 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase RINT1_TIP1 PF04437.13 AAS51634.1 - 3e-90 303.5 22.5 3.7e-90 303.2 22.5 1.1 1 0 0 1 1 1 1 RINT-1 / TIP-1 family baeRF_family6 PF18848.1 AAS51634.1 - 0.075 13.4 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 HopW1-1 PF15457.6 AAS51634.1 - 0.11 11.7 3.2 0.083 12.1 0.9 1.8 1 1 0 2 2 2 0 Type III T3SS secreted effector HopW1-1/HopPmaA DUF676 PF05057.14 AAS51635.1 - 5.1e-56 189.6 0.0 7.9e-56 189.0 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AAS51635.1 - 0.0014 18.5 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 AAS51635.1 - 0.033 14.1 0.0 0.1 12.5 0.0 1.9 1 1 0 1 1 1 0 Lipase (class 3) PGAP1 PF07819.13 AAS51635.1 - 0.14 11.9 0.5 0.39 10.4 0.5 1.7 1 1 0 1 1 1 0 PGAP1-like protein PCRF PF03462.18 AAS51636.2 - 1.1e-54 185.2 2.9 2.3e-54 184.2 0.0 2.1 2 0 0 2 2 2 1 PCRF domain RF-1 PF00472.20 AAS51636.2 - 1.4e-38 131.4 2.4 3.3e-38 130.2 2.4 1.6 1 0 0 1 1 1 1 RF-1 domain RICTOR_N PF14664.6 AAS51636.2 - 0.06 12.3 0.4 0.097 11.6 0.4 1.3 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term OmpH PF03938.14 AAS51636.2 - 0.15 12.4 3.1 8.9 6.7 0.3 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Pkinase PF00069.25 AAS51637.1 - 1.8e-69 234.1 0.0 2e-69 233.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51637.1 - 1.3e-29 103.3 0.0 1.7e-29 102.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51637.1 - 0.00072 19.0 0.1 0.0012 18.3 0.1 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AAS51637.1 - 0.001 19.0 0.4 0.0021 18.0 0.4 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 AAS51637.1 - 0.025 14.2 0.0 0.04 13.5 0.0 1.2 1 0 0 1 1 1 0 RIO1 family TPR_2 PF07719.17 AAS51638.1 - 3.7e-05 23.5 0.7 0.18 12.0 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51638.1 - 9.3e-05 22.6 3.6 0.24 11.7 0.2 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51638.1 - 0.00017 22.2 4.2 0.0042 17.7 0.1 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 AAS51638.1 - 0.0062 17.2 1.1 1.2 10.0 0.0 3.6 3 0 0 3 3 3 1 Sel1 repeat TPR_8 PF13181.6 AAS51638.1 - 0.0091 16.1 3.7 12 6.4 0.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS51638.1 - 0.0092 16.0 0.4 3.4 7.9 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 AAS51638.1 - 0.038 13.4 3.0 0.76 9.1 0.2 2.9 2 1 0 2 2 2 0 MalT-like TPR region TPR_6 PF13174.6 AAS51638.1 - 0.35 11.6 4.3 28 5.6 0.1 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_22 PF03901.17 AAS51639.1 - 7.2e-100 335.1 18.4 8.4e-100 334.9 18.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family HECT PF00632.25 AAS51640.1 - 4.7e-81 272.6 0.1 6.4e-81 272.2 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) IQ PF00612.27 AAS51640.1 - 0.31 10.9 4.4 0.35 10.8 2.1 2.3 2 0 0 2 2 2 0 IQ calmodulin-binding motif SPRY PF00622.28 AAS51641.1 - 5.4e-12 45.9 0.0 9.8e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 SPRY domain MMR_HSR1 PF01926.23 AAS51642.2 - 9.5e-09 35.3 0.0 3.7e-08 33.4 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS51642.2 - 0.00032 20.7 0.0 0.001 19.0 0.0 1.8 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 AAS51642.2 - 0.0013 18.3 0.0 0.016 14.7 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 AAS51642.2 - 0.0043 17.6 0.0 0.0068 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain DUF2532 PF10811.8 AAS51642.2 - 0.055 13.5 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) FeoB_N PF02421.18 AAS51642.2 - 0.091 12.3 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 AAS51642.2 - 0.1 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 AAS51642.2 - 0.17 11.9 0.1 0.42 10.6 0.1 1.6 1 1 0 1 1 1 0 Dynamin family Noc2 PF03715.13 AAS51643.1 - 3.5e-123 410.6 2.3 3.5e-123 410.6 2.3 2.6 3 1 1 4 4 4 1 Noc2p family Mei5 PF10376.9 AAS51644.1 - 4.9e-25 88.6 3.5 5.4e-25 88.5 3.5 1.1 1 0 0 1 1 1 1 Double-strand recombination repair protein Laps PF10169.9 AAS51644.1 - 1.3 9.6 7.0 8.3 7.0 1.8 2.3 1 1 1 2 2 2 0 Learning-associated protein FeoB_Cyto PF17910.1 AAS51644.1 - 2.2 8.9 8.0 8.9 6.9 2.8 2.8 2 1 1 3 3 3 0 FeoB cytosolic helical domain RNA_pol_Rpb2_6 PF00562.28 AAS51645.2 - 3e-124 415.1 0.2 3e-124 415.1 0.2 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AAS51645.2 - 3.2e-59 199.8 1.7 5e-59 199.2 1.7 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AAS51645.2 - 2.2e-41 141.6 4.5 4.2e-41 140.7 4.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AAS51645.2 - 1.1e-33 115.4 0.2 3.9e-33 113.7 0.2 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AAS51645.2 - 8.5e-27 93.2 0.6 2.9e-26 91.5 0.6 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AAS51645.2 - 2.6e-18 65.9 0.0 5.9e-18 64.8 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AAS51645.2 - 3.8e-11 43.4 0.7 1.5e-10 41.4 0.7 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF370 PF04025.12 AAS51645.2 - 0.29 11.3 1.4 0.62 10.2 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF370) Tfb2 PF03849.14 AAS51646.1 - 9.7e-142 472.1 0.4 1.2e-141 471.8 0.4 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 AAS51646.1 - 1.6e-22 79.7 0.7 3.3e-22 78.7 0.7 1.6 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 AAS51646.1 - 0.0001 22.5 0.0 0.00024 21.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AAS51647.2 - 3.7e-49 166.9 0.0 6.9e-49 166.0 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51647.2 - 4.1e-31 107.6 0.0 1.3e-30 106.0 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51647.2 - 0.0011 19.0 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AAS51647.2 - 0.016 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase UTP25 PF06862.12 AAS51647.2 - 0.17 10.7 0.0 0.61 8.8 0.0 1.9 2 0 0 2 2 2 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AA_permease PF00324.21 AAS51648.1 - 7.3e-121 404.1 37.3 8.3e-121 403.9 37.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS51648.1 - 5e-41 140.9 39.3 6.1e-41 140.6 39.3 1.0 1 0 0 1 1 1 1 Amino acid permease Mit_ribos_Mrp51 PF11709.8 AAS51649.1 - 5e-59 200.7 4.8 7e-39 134.5 2.2 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein subunit IGPD PF00475.18 AAS51650.2 - 7.8e-62 207.8 0.4 1.2e-61 207.2 0.4 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase SpoU_methylase PF00588.19 AAS51651.1 - 9.4e-25 87.4 0.0 1.6e-24 86.7 0.0 1.4 1 0 0 1 1 1 1 SpoU rRNA Methylase family SpoU_sub_bind PF08032.12 AAS51651.1 - 3e-16 59.5 0.1 5.9e-16 58.5 0.1 1.5 1 0 0 1 1 1 1 RNA 2'-O ribose methyltransferase substrate binding NUDIX PF00293.28 AAS51652.1 - 1.7e-28 99.3 0.0 2.5e-28 98.7 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Baculo_PEP_C PF04513.12 AAS51653.2 - 0.00059 19.9 10.8 0.48 10.5 2.5 4.4 2 1 2 4 4 4 3 Baculovirus polyhedron envelope protein, PEP, C terminus FapA PF03961.13 AAS51653.2 - 0.00063 18.5 8.9 0.00063 18.5 8.9 3.8 2 1 1 3 3 3 1 Flagellar Assembly Protein A HOOK PF05622.12 AAS51653.2 - 0.00087 17.6 8.4 0.00087 17.6 8.4 3.3 3 0 0 3 3 3 2 HOOK protein Sec34 PF04136.15 AAS51653.2 - 1.6 8.6 18.0 0.29 11.0 1.2 3.8 3 1 1 4 4 4 0 Sec34-like family Peptidase_C14 PF00656.22 AAS51654.1 - 3.9e-66 223.5 0.0 5e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Hist_deacetyl PF00850.19 AAS51655.2 - 1.5e-52 179.0 0.3 2.8e-52 178.1 0.3 1.4 1 0 0 1 1 1 1 Histone deacetylase domain CDV3 PF15359.6 AAS51655.2 - 0.14 12.6 3.8 0.098 13.1 1.1 2.1 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 Mito_carr PF00153.27 AAS51656.1 - 1.3e-52 175.7 4.1 1.1e-17 63.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein ING PF12998.7 AAS51657.2 - 1.7e-23 83.1 0.1 7.5e-23 81.0 0.0 1.9 2 0 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AAS51657.2 - 7.7e-05 22.5 8.2 0.00015 21.6 8.2 1.5 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AAS51657.2 - 0.01 16.1 0.6 0.025 14.8 0.6 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain PHD_2 PF13831.6 AAS51657.2 - 0.11 12.1 1.7 0.24 11.0 1.7 1.6 1 0 0 1 1 1 0 PHD-finger Ras PF00071.22 AAS51658.2 - 1.3e-55 187.4 0.1 1.6e-55 187.1 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51658.2 - 1.5e-19 70.4 0.0 2.2e-19 69.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51658.2 - 7e-10 38.6 0.0 8.5e-10 38.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AAS51658.2 - 6.2e-05 22.6 0.1 0.00049 19.7 0.0 1.9 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS51658.2 - 0.0005 20.0 0.4 0.27 11.1 0.2 2.5 1 1 2 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 AAS51658.2 - 0.0016 18.5 0.0 0.0028 17.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AAS51658.2 - 0.031 14.3 0.0 0.1 12.6 0.0 1.8 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain DAD PF02109.16 AAS51659.1 - 2.5e-35 121.0 2.2 3e-35 120.8 2.2 1.1 1 0 0 1 1 1 1 DAD family Cytochrom_B_C PF00032.17 AAS51659.1 - 0.11 12.8 1.7 0.32 11.3 1.7 2.0 1 1 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD Y_phosphatase2 PF03162.13 AAS51660.1 - 2e-55 186.9 0.0 2.3e-55 186.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AAS51660.1 - 6.4e-06 26.3 0.0 1.6e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 AAS51660.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain DUF2474 PF10617.9 AAS51661.1 - 0.13 12.2 2.7 0.21 11.5 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2474) Podoplanin PF05808.11 AAS51661.1 - 0.19 11.8 0.4 0.31 11.1 0.4 1.3 1 0 0 1 1 1 0 Podoplanin HemY_N PF07219.13 AAS51661.1 - 0.42 10.8 1.3 0.83 9.9 1.3 1.4 1 1 0 1 1 1 0 HemY protein N-terminus MFS_1 PF07690.16 AAS51662.1 - 3.1e-38 131.6 32.2 3.1e-38 131.6 32.2 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS51662.1 - 1.6e-09 37.2 12.6 1.6e-09 37.2 12.6 2.3 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 AAS51662.1 - 3.7e-06 25.6 1.8 5.3e-06 25.1 1.8 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) OATP PF03137.20 AAS51662.1 - 4.2e-05 22.1 1.8 0.052 11.8 0.0 2.5 1 1 1 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family DnaJ_C PF01556.18 AAS51663.1 - 1.2e-40 139.0 0.1 1.5e-40 138.7 0.1 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AAS51663.1 - 5.6e-26 90.5 1.9 9.1e-26 89.8 1.9 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AAS51663.1 - 1e-15 57.8 16.6 2.1e-15 56.8 16.6 1.6 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AAS51663.1 - 0.036 14.0 2.2 0.036 14.0 2.2 2.6 1 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein MAGP PF05507.11 AAS51663.1 - 0.098 13.1 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) CxC3 PF18804.1 AAS51663.1 - 0.15 11.9 0.4 0.3 11.0 0.4 1.5 1 0 0 1 1 1 0 CxC3 like cysteine cluster associated with KDZ transposases GRP PF07172.11 AAS51663.1 - 0.18 12.5 8.6 0.5 11.1 8.6 1.8 1 0 0 1 1 1 0 Glycine rich protein family Fra10Ac1 PF09725.9 AAS51663.1 - 0.29 11.2 1.1 1.9 8.6 0.0 2.3 2 0 0 2 2 2 0 Folate-sensitive fragile site protein Fra10Ac1 HypA PF01155.19 AAS51663.1 - 0.76 9.8 10.5 5.1 7.1 1.9 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA MTS PF05175.14 AAS51664.1 - 6.1e-12 45.4 0.0 8.6e-12 44.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AAS51664.1 - 2.5e-09 37.7 0.1 1e-08 35.7 0.1 2.0 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS51664.1 - 1.8e-06 27.8 0.0 2.9e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS51664.1 - 4.3e-05 24.1 0.3 0.0002 21.9 0.1 2.1 1 1 1 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AAS51664.1 - 0.00033 20.4 0.0 0.00051 19.7 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 PrmA PF06325.13 AAS51664.1 - 0.0028 17.1 0.0 0.0039 16.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_10 PF05971.12 AAS51664.1 - 0.0041 16.5 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 RNA methyltransferase Methyltransf_12 PF08242.12 AAS51664.1 - 0.0056 17.4 0.0 0.0096 16.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AAS51664.1 - 0.0063 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.7 AAS51664.1 - 0.02 14.9 0.0 0.029 14.3 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_16 PF10294.9 AAS51664.1 - 0.032 14.0 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Methyltransf_32 PF13679.6 AAS51664.1 - 0.061 13.3 0.0 0.092 12.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Gcd10p PF04189.13 AAS51665.1 - 5.6e-98 327.8 0.1 6.8e-98 327.5 0.1 1.1 1 0 0 1 1 1 1 Gcd10p family CNP_C_terminal PF17839.1 AAS51665.1 - 0.11 13.2 1.9 0.23 12.2 0.1 2.3 2 1 0 2 2 2 0 C-terminal domain of cyclic nucleotide phosphodiesterase Methyltr_RsmB-F PF01189.17 AAS51666.1 - 1.1e-82 276.5 0.0 2e-82 275.7 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AAS51666.1 - 1.4e-08 35.1 0.0 6.3e-08 33.0 0.0 2.2 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AAS51666.1 - 0.018 15.2 0.0 0.041 14.0 0.0 1.6 1 0 0 1 1 1 0 FtsJ-like methyltransferase Actin PF00022.19 AAS51667.2 - 4.2e-47 160.7 0.1 4.9e-26 91.3 0.0 2.2 2 0 0 2 2 2 2 Actin MreB_Mbl PF06723.13 AAS51667.2 - 0.12 11.2 0.1 0.38 9.5 0.0 1.8 2 0 0 2 2 2 0 MreB/Mbl protein Ras PF00071.22 AAS51668.1 - 2.2e-56 190.0 0.0 2.5e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS51668.1 - 4.9e-23 81.6 0.0 6.8e-23 81.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51668.1 - 6.5e-09 35.5 0.0 1.1e-08 34.7 0.0 1.3 2 0 0 2 2 2 1 ADP-ribosylation factor family SRPRB PF09439.10 AAS51668.1 - 0.00089 18.7 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AAS51668.1 - 0.0046 16.2 0.0 0.0048 16.1 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 AAS51668.1 - 0.0059 16.0 0.0 0.0076 15.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS51668.1 - 0.006 16.7 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase DLIC PF05783.11 AAS51668.1 - 0.011 14.6 0.1 0.025 13.4 0.1 1.6 1 1 0 1 1 1 0 Dynein light intermediate chain (DLIC) ABC_tran PF00005.27 AAS51668.1 - 0.069 13.7 0.0 0.093 13.2 0.0 1.3 1 0 0 1 1 1 0 ABC transporter TRP PF06011.12 AAS51669.1 - 0.066 11.9 0.0 0.086 11.6 0.0 1.1 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel SieB PF14163.6 AAS51669.1 - 0.2 11.1 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 Super-infection exclusion protein B Y_phosphatase2 PF03162.13 AAS51670.1 - 4e-51 172.9 0.0 4.8e-51 172.6 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AAS51670.1 - 1e-06 28.9 0.0 1.2e-06 28.7 0.0 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Arginase PF00491.21 AAS51670.1 - 0.14 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Arginase family Aminotran_1_2 PF00155.21 AAS51671.1 - 5.3e-56 190.3 0.0 6.1e-56 190.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 AAS51671.1 - 1.9e-06 27.0 0.0 2.7e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.19 AAS51671.1 - 0.0032 16.5 0.0 0.0092 15.0 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AAS51671.1 - 0.031 12.8 0.1 0.076 11.5 0.0 1.6 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme NUP214 PF16755.5 AAS51672.2 - 2.3e-72 244.2 0.0 7.3e-72 242.6 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 Porin_3 PF01459.22 AAS51673.2 - 1.1e-70 238.2 0.1 1.3e-70 237.9 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic porin Vac7 PF12751.7 AAS51674.1 - 3.2e-30 105.8 18.3 7.7e-21 75.0 0.2 3.2 3 0 0 3 3 3 2 Vacuolar segregation subunit 7 DSPc PF00782.20 AAS51675.1 - 1.8e-36 124.9 0.1 2.4e-36 124.5 0.1 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AAS51675.1 - 0.0028 17.2 0.0 0.0042 16.7 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Ank_2 PF12796.7 AAS51676.2 - 1.2e-37 128.4 2.8 3.8e-17 62.6 0.2 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AAS51676.2 - 3.1e-29 100.9 0.2 1.7e-10 41.2 0.0 4.9 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 AAS51676.2 - 5.3e-28 96.7 3.2 1e-07 32.1 0.2 4.8 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 AAS51676.2 - 1.1e-26 92.1 3.4 3e-08 33.7 0.2 6.3 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 AAS51676.2 - 8.3e-24 81.1 0.4 1.6e-07 31.0 0.2 6.5 7 0 0 7 7 7 4 Ankyrin repeat COX4 PF02936.14 AAS51677.1 - 1.8e-34 118.7 0.1 2.1e-34 118.5 0.1 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV RHS PF03527.14 AAS51677.1 - 0.0056 16.4 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 RHS protein DUF1289 PF06945.13 AAS51677.1 - 0.26 11.1 1.1 24 4.8 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1289) COG5 PF10392.9 AAS51679.1 - 6.7e-43 146.0 2.0 6.7e-43 146.0 2.0 2.4 2 0 0 2 2 2 1 Golgi transport complex subunit 5 Phage_sheath_1C PF17482.2 AAS51679.1 - 0.05 13.6 0.2 0.45 10.5 0.1 2.3 2 0 0 2 2 2 0 Phage tail sheath C-terminal domain Baculo_8kDa PF06096.11 AAS51679.1 - 0.098 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Baculoviridae 8.2 KDa protein DUF2011 PF09428.10 AAS51680.1 - 3.5e-20 72.0 0.1 7.2e-20 71.0 0.1 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF2011) Sec23_trunk PF04811.15 AAS51681.1 - 3e-69 233.3 0.0 6.9e-69 232.1 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 AAS51681.1 - 4.2e-21 74.7 0.1 1.2e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AAS51681.1 - 4.1e-18 65.1 3.9 7.1e-18 64.4 3.9 1.4 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 AAS51681.1 - 5.4e-18 65.5 0.1 1.1e-16 61.3 0.1 2.9 3 0 0 3 3 3 1 Sec23/Sec24 beta-sandwich domain Gelsolin PF00626.22 AAS51681.1 - 1.1e-10 41.2 0.0 2.3e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AAS51681.1 - 0.089 12.2 0.0 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Metallopep PF12044.8 AAS51682.2 - 1.7e-171 570.6 0.0 2.2e-171 570.2 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Jacalin PF01419.17 AAS51682.2 - 0.00021 21.3 0.0 0.00075 19.4 0.0 1.9 1 1 1 2 2 2 1 Jacalin-like lectin domain Reprolysin_3 PF13582.6 AAS51682.2 - 0.023 15.2 0.1 0.048 14.2 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 AAS51682.2 - 0.049 13.8 0.2 0.087 13.0 0.2 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 AAS51682.2 - 0.18 11.6 0.2 0.32 10.8 0.2 1.4 1 0 0 1 1 1 0 Matrixin 6PF2K PF01591.18 AAS51683.1 - 9.3e-79 263.8 0.1 1.4e-78 263.3 0.1 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AAS51683.1 - 6.1e-32 110.9 0.0 7.9e-25 87.7 0.0 2.5 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AAS51683.1 - 5.4e-06 26.6 0.0 1.3e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 AAS51683.1 - 0.0004 19.9 0.0 0.00088 18.8 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 AAS51683.1 - 0.0043 17.6 0.0 0.013 16.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Pox_A28 PF04584.14 AAS51683.1 - 0.032 14.4 0.0 0.069 13.3 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A28 family ARL2_Bind_BART PF11527.8 AAS51683.1 - 0.066 13.3 0.4 0.49 10.5 0.0 2.5 3 1 0 3 3 3 0 The ARF-like 2 binding protein BART Zeta_toxin PF06414.12 AAS51683.1 - 0.1 11.8 0.0 0.23 10.7 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin Mob1_phocein PF03637.17 AAS51684.1 - 1.3e-65 220.5 0.3 1.8e-65 220.1 0.3 1.2 1 0 0 1 1 1 1 Mob1/phocein family ALG11_N PF15924.5 AAS51685.1 - 6.1e-79 264.9 0.1 8.9e-79 264.4 0.1 1.3 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 AAS51685.1 - 2.6e-17 62.9 0.0 5.7e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AAS51685.1 - 1e-06 29.2 0.0 2.1e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AAS51685.1 - 0.0018 18.3 0.0 0.0035 17.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 DUF2220 PF09983.9 AAS51685.1 - 0.0051 16.2 0.0 0.0098 15.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria C-term(DUF2220) PH PF00169.29 AAS51686.1 - 7.2e-10 39.3 0.7 1.9e-09 38.0 0.7 1.7 1 0 0 1 1 1 1 PH domain RTT107_BRCT_5 PF16770.5 AAS51686.1 - 0.13 12.2 0.0 0.48 10.3 0.0 1.9 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Peptidase_M1 PF01433.20 AAS51687.2 - 1.6e-36 126.0 0.0 2.4e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 AAS51687.2 - 2.4e-31 108.2 0.0 5e-31 107.1 0.0 1.6 1 0 0 1 1 1 1 Leukotriene A4 hydrolase, C-terminal Peptidase_M1_N PF17900.1 AAS51687.2 - 1.2e-16 61.4 0.0 2.1e-16 60.6 0.0 1.4 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain Peptidase_MA_2 PF13485.6 AAS51687.2 - 0.12 12.1 0.3 0.24 11.1 0.3 1.4 1 0 0 1 1 1 0 Peptidase MA superfamily PRA1 PF03208.19 AAS51688.1 - 2e-38 131.3 2.3 2.3e-38 131.0 2.3 1.0 1 0 0 1 1 1 1 PRA1 family protein DUF2207 PF09972.9 AAS51688.1 - 4.9 5.8 6.2 6.1 5.5 6.2 1.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2722 PF10846.8 AAS51689.2 - 1.3e-39 136.5 13.3 1.2e-36 126.7 7.6 2.8 1 1 1 2 2 2 2 Protein of unknown function (DUF2722) SHQ1 PF04925.15 AAS51690.1 - 1.7e-63 213.4 0.1 2.4e-63 212.9 0.1 1.2 1 0 0 1 1 1 1 SHQ1 protein Diphthamide_syn PF01866.17 AAS51691.1 - 7.8e-116 386.8 0.0 9.5e-116 386.5 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein COG6 PF06419.11 AAS51692.2 - 2.2e-139 465.5 19.6 2.8e-139 465.2 19.6 1.1 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 IcmF-related PF06761.12 AAS51692.2 - 0.044 13.2 1.5 0.11 11.9 1.5 1.6 1 0 0 1 1 1 0 Intracellular multiplication and human macrophage-killing Pro_CA PF00484.19 AAS51694.1 - 7.6e-35 120.5 0.1 9.9e-35 120.1 0.1 1.1 1 0 0 1 1 1 1 Carbonic anhydrase Glyco_hydro_15 PF00723.21 AAS51695.2 - 3.4e-48 164.6 0.0 4.7e-48 164.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 Complex1_LYR_2 PF13233.6 AAS51696.1 - 7.7e-16 58.6 5.2 2.1e-15 57.2 5.2 1.8 1 1 0 1 1 1 1 Complex1_LYR-like AcetDehyd-dimer PF09290.11 AAS51696.1 - 0.09 13.0 0.2 0.27 11.4 0.2 1.9 1 1 0 1 1 1 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation Spectrin PF00435.21 AAS51696.1 - 0.74 10.3 5.6 1.5 9.3 5.6 1.5 1 0 0 1 1 1 0 Spectrin repeat Iso_dh PF00180.20 AAS51697.1 - 2.8e-81 273.4 0.1 3.1e-81 273.2 0.1 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pim PF16765.5 AAS51697.1 - 0.071 13.3 0.1 13 6.0 0.1 2.5 2 0 0 2 2 2 0 Pesticin immunity protein DUF465 PF04325.13 AAS51697.1 - 0.21 11.6 0.1 0.46 10.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF465) CLTH PF10607.9 AAS51698.1 - 6.8e-29 100.7 2.8 6.8e-29 100.7 2.8 2.5 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain U-box PF04564.15 AAS51698.1 - 0.016 15.4 0.0 0.066 13.4 0.0 2.1 1 0 0 1 1 1 0 U-box domain DUF2431 PF10354.9 AAS51699.1 - 2.6e-51 174.3 0.1 6.1e-51 173.0 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Gemini_AL1_M PF08283.11 AAS51699.1 - 0.1 12.7 0.7 0.25 11.4 0.1 1.8 2 0 0 2 2 2 0 Geminivirus rep protein central domain PIG-H PF10181.9 AAS51700.1 - 2.3e-19 69.0 0.2 3.5e-19 68.5 0.2 1.3 1 0 0 1 1 1 1 GPI-GlcNAc transferase complex, PIG-H component Myb_DNA-bind_7 PF15963.5 AAS51701.1 - 1.6e-28 98.4 0.1 1.6e-28 98.4 0.1 2.7 3 0 0 3 3 3 1 Myb DNA-binding like Myb_DNA-binding PF00249.31 AAS51701.1 - 6.8e-09 35.8 0.4 1.9e-08 34.4 0.0 1.9 2 0 0 2 2 2 1 Myb-like DNA-binding domain WD40 PF00400.32 AAS51702.1 - 5.8e-08 33.3 0.6 0.0008 20.2 0.2 4.0 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51702.1 - 0.0014 18.9 0.1 2.6 8.4 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2415 PF10313.9 AAS51702.1 - 0.019 14.8 0.4 1.7 8.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) Nucleoporin_N PF08801.11 AAS51702.1 - 0.086 11.6 0.0 0.46 9.2 0.0 1.9 2 0 0 2 2 2 0 Nup133 N terminal like Methyltransf_32 PF13679.6 AAS51702.1 - 0.21 11.5 0.7 1.4 8.9 0.0 2.3 2 1 0 2 2 2 0 Methyltransferase domain Pkinase PF00069.25 AAS51703.2 - 3.1e-38 131.7 0.0 5.2e-38 130.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51703.2 - 1.4e-27 96.7 0.0 2.1e-27 96.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51703.2 - 0.0039 16.5 0.0 0.0078 15.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Arb2 PF09757.9 AAS51704.2 - 6.2e-92 307.4 0.0 8.4e-92 307.0 0.0 1.2 1 0 0 1 1 1 1 Arb2 domain Hist_deacetyl PF00850.19 AAS51704.2 - 1.1e-87 294.3 0.0 1.6e-87 293.9 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Baculo_ODV-E27 PF05314.11 AAS51704.2 - 0.2 10.8 0.0 0.35 10.0 0.0 1.2 1 0 0 1 1 1 0 Baculovirus occlusion-derived virus envelope protein EC27 Methyltr_RsmB-F PF01189.17 AAS51705.1 - 1.4e-20 73.8 0.0 9.1e-13 48.3 0.0 2.9 3 0 0 3 3 3 2 16S rRNA methyltransferase RsmB/F Iso_dh PF00180.20 AAS51706.1 - 2.4e-104 349.3 0.0 2.8e-104 349.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pox_C4_C10 PF03336.13 AAS51706.1 - 0.0089 15.2 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Poxvirus C4/C10 protein PdxA PF04166.12 AAS51706.1 - 0.11 11.8 0.1 0.28 10.5 0.0 1.6 2 0 0 2 2 2 0 Pyridoxal phosphate biosynthetic protein PdxA R3H PF01424.22 AAS51707.2 - 5.1e-19 68.0 0.1 9.5e-19 67.1 0.1 1.5 1 0 0 1 1 1 1 R3H domain zf-NF-X1 PF01422.17 AAS51707.2 - 2.6e-11 43.3 52.7 3.1e-06 27.1 15.9 12.9 13 1 0 13 13 13 4 NF-X1 type zinc finger Methyltransf_16 PF10294.9 AAS51708.1 - 1.6e-56 190.8 0.0 2.1e-56 190.4 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase MRP-S25 PF13741.6 AAS51709.2 - 2.5e-91 305.3 1.2 3.4e-91 304.9 1.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal protein S25 MRP-S23 PF10484.9 AAS51709.2 - 0.013 15.7 4.5 0.095 13.0 0.1 3.3 2 2 0 3 3 3 0 Mitochondrial ribosomal protein S23 DUF1242 PF06842.12 AAS51710.1 - 1.9e-15 56.4 0.1 2.4e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1242) UTP25 PF06862.12 AAS51711.1 - 1.4e-201 670.4 6.8 1.8e-201 670.0 6.8 1.1 1 0 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 DEAD PF00270.29 AAS51711.1 - 8.4e-05 22.4 0.2 0.5 10.1 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase TT_ORF2a PF08197.11 AAS51711.1 - 0.13 12.2 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 pORF2a truncated protein ICE2 PF08426.10 AAS51712.1 - 2.2e-149 498.0 23.3 2.5e-149 497.8 23.3 1.0 1 0 0 1 1 1 1 ICE2 Cyclin_N PF00134.23 AAS51713.1 - 1.7e-16 60.1 0.6 5.1e-16 58.6 0.3 1.9 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 AAS51713.1 - 1.6e-06 28.4 0.1 3.6e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Cyclin C-terminal domain Cyclin_C PF02984.19 AAS51713.1 - 3.8e-05 23.8 0.2 0.027 14.5 0.0 2.4 2 0 0 2 2 2 2 Cyclin, C-terminal domain TRAM_LAG1_CLN8 PF03798.16 AAS51714.1 - 1.3e-41 142.5 23.9 2.4e-41 141.7 23.9 1.4 1 0 0 1 1 1 1 TLC domain TRAM1 PF08390.11 AAS51714.1 - 7.8e-15 54.3 1.0 1.2e-13 50.5 0.0 2.9 3 0 0 3 3 3 1 TRAM1-like protein Aa_trans PF01490.18 AAS51715.1 - 1.6e-100 336.7 11.6 1.9e-100 336.5 11.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Y_phosphatase2 PF03162.13 AAS51716.1 - 1.3e-61 207.0 0.0 1.6e-61 206.7 0.0 1.0 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 AAS51716.1 - 1.3e-06 28.6 0.0 1.6e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 AAS51716.1 - 0.0027 17.3 0.0 0.0035 17.0 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 AAS51716.1 - 0.0031 17.3 0.0 0.0038 17.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Aim19 PF10315.9 AAS51717.1 - 2.1e-36 124.7 2.8 2.4e-36 124.5 2.8 1.0 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 19 Histone PF00125.24 AAS51718.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AAS51718.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AAS51718.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AAS51718.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AAS51718.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AAS51718.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit CENP-T_C PF15511.6 AAS51719.2 - 2.6e-09 37.2 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AAS51719.2 - 2.8e-05 24.5 0.1 3.2e-05 24.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AAS51719.2 - 4.6e-05 23.5 0.2 6.8e-05 23.0 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AAS51719.2 - 8.8e-05 22.7 0.1 0.00016 21.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AAS51719.2 - 0.0002 21.6 0.1 0.00027 21.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AAS51719.2 - 0.0039 17.3 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AAS51719.2 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AAS51719.2 - 0.044 14.3 0.1 0.075 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Sds3 PF08598.11 AAS51720.2 - 2e-73 247.0 7.2 2.3e-73 246.8 7.2 1.1 1 0 0 1 1 1 1 Sds3-like STAT_int PF02865.17 AAS51720.2 - 0.19 12.2 6.0 0.78 10.2 0.5 2.3 2 0 0 2 2 2 0 STAT protein, protein interaction domain Met_10 PF02475.16 AAS51721.2 - 8.4e-10 38.7 0.0 1.5e-09 37.9 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein Cons_hypoth95 PF03602.15 AAS51721.2 - 0.00029 20.5 0.0 0.00053 19.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 MTS PF05175.14 AAS51721.2 - 0.049 13.2 0.0 0.091 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain zf-C2H2 PF00096.26 AAS51722.2 - 6.8e-14 51.4 13.3 8e-07 29.2 2.7 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS51722.2 - 2.1e-12 46.9 10.9 1.8e-07 31.3 0.4 4.3 3 1 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS51722.2 - 2.8e-08 33.9 12.2 0.0021 18.8 1.5 3.9 3 0 0 3 3 3 3 C2H2-type zinc finger zf-met PF12874.7 AAS51722.2 - 1.3e-06 28.6 4.7 9.6e-05 22.6 0.7 3.2 3 0 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AAS51722.2 - 6.9e-06 26.2 6.4 0.012 15.9 0.7 3.5 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AAS51722.2 - 2.6e-05 24.1 8.6 0.01 15.9 0.3 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger Zn_ribbon_recom PF13408.6 AAS51722.2 - 0.0009 19.7 2.4 0.0009 19.7 2.4 2.0 2 0 0 2 2 2 1 Recombinase zinc beta ribbon domain FYVE PF01363.21 AAS51722.2 - 0.14 12.3 4.4 0.26 11.5 4.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger Zn-ribbon_8 PF09723.10 AAS51722.2 - 0.32 11.2 0.9 0.81 9.9 0.9 1.8 1 0 0 1 1 1 0 Zinc ribbon domain zf-C2H2_11 PF16622.5 AAS51722.2 - 0.63 9.8 4.5 22 4.9 0.3 3.3 3 0 0 3 3 3 0 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 AAS51722.2 - 0.89 9.4 4.2 2.3 8.1 3.7 2.0 2 0 0 2 2 2 0 C2H2-type zinc-finger domain C1_2 PF03107.16 AAS51722.2 - 0.93 9.9 3.6 10 6.5 0.2 2.6 1 1 1 2 2 2 0 C1 domain zf-AN1 PF01428.16 AAS51722.2 - 3 8.1 5.4 5.8 7.2 1.3 2.4 2 0 0 2 2 2 0 AN1-like Zinc finger zf-LYAR PF08790.11 AAS51722.2 - 3 7.8 4.2 32 4.5 0.1 3.2 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger DHHC PF01529.20 AAS51723.1 - 5.1e-32 110.8 16.7 5.1e-32 110.8 16.7 2.1 2 1 0 2 2 2 1 DHHC palmitoyltransferase KH_6 PF15985.5 AAS51724.2 - 4.8e-15 55.6 0.0 6.9e-15 55.1 0.0 1.3 1 0 0 1 1 1 1 KH domain Syja_N PF02383.18 AAS51725.2 - 2.2e-78 263.8 0.1 2.2e-78 263.8 0.1 2.0 2 1 0 2 2 2 1 SacI homology domain DMAP_binding PF06464.11 AAS51725.2 - 2.6 8.9 8.1 0.63 10.9 4.5 1.8 2 0 0 2 2 2 0 DMAP1-binding Domain LCM PF04072.14 AAS51726.1 - 5e-24 85.3 0.0 7.4e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Kelch_4 PF13418.6 AAS51726.1 - 4.5e-18 65.0 5.8 6.4e-12 45.3 0.0 5.0 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 AAS51726.1 - 1e-07 31.8 0.3 0.0067 16.4 0.0 5.1 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 AAS51726.1 - 1.3e-06 28.4 3.0 0.029 14.6 0.0 5.3 5 1 1 6 6 6 2 Kelch motif Kelch_3 PF13415.6 AAS51726.1 - 3.1e-05 24.1 1.9 5.6 7.4 0.0 4.9 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 AAS51726.1 - 0.00061 19.7 2.3 1.8 8.7 0.0 4.1 5 0 0 5 5 5 2 Kelch motif DUF3533 PF12051.8 AAS51727.2 - 2.4e-99 332.8 6.2 2.8e-99 332.6 6.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) CDC50 PF03381.15 AAS51728.2 - 1.1e-76 258.0 0.0 1.5e-76 257.6 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Aminotran_3 PF00202.21 AAS51729.1 - 2e-122 408.8 0.0 2.4e-122 408.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_5 PF00266.19 AAS51729.1 - 0.0032 16.5 0.0 0.0054 15.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V PapC_C PF13953.6 AAS51729.1 - 0.0072 16.1 0.5 0.014 15.1 0.2 1.6 2 0 0 2 2 2 1 PapC C-terminal domain Aminotran_1_2 PF00155.21 AAS51729.1 - 0.018 14.2 0.0 0.059 12.5 0.0 1.8 1 1 0 1 1 1 0 Aminotransferase class I and II IceA2 PF05862.11 AAS51729.1 - 0.067 13.1 0.2 2.3 8.2 0.1 2.4 2 0 0 2 2 2 0 Helicobacter pylori IceA2 protein KRE1 PF17056.5 AAS51730.1 - 2.3e-17 62.5 1.1 4.8e-17 61.4 1.1 1.5 1 0 0 1 1 1 1 Killer toxin-resistance protein 1 GREB1 PF15782.5 AAS51730.1 - 6.9 3.6 9.1 7.6 3.5 9.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 AAS51730.1 - 8.8 6.2 32.2 11 5.9 32.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Na_Ca_ex PF01699.24 AAS51731.2 - 2.3e-23 82.8 27.5 1e-18 67.7 11.1 3.2 4 0 0 4 4 4 2 Sodium/calcium exchanger protein YccF PF03733.13 AAS51731.2 - 2.2e-11 44.3 3.3 2.2e-11 44.3 3.3 5.3 6 1 1 7 7 7 1 Inner membrane component domain IF4E PF01652.18 AAS51732.2 - 2.5e-51 173.6 0.0 3e-51 173.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Toprim_Crpt PF13342.6 AAS51732.2 - 0.089 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Hydrolase_4 PF12146.8 AAS51733.1 - 2.7e-17 62.8 0.0 7.2e-10 38.5 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AAS51733.1 - 2.1e-12 47.2 0.0 2.9e-07 30.4 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 AAS51733.1 - 1.3e-05 24.8 0.0 0.00011 21.7 0.0 2.2 1 1 0 1 1 1 1 Prolyl oligopeptidase family AXE1 PF05448.12 AAS51733.1 - 0.00044 19.0 0.1 0.2 10.3 0.0 2.7 2 1 1 3 3 3 2 Acetyl xylan esterase (AXE1) BAAT_C PF08840.11 AAS51733.1 - 0.00085 19.3 0.0 0.11 12.4 0.0 2.5 1 1 1 3 3 3 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.7 AAS51733.1 - 0.0078 16.8 0.0 0.016 15.8 0.0 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.13 AAS51733.1 - 0.0079 15.9 0.0 0.011 15.5 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AAS51733.1 - 0.042 13.6 0.0 0.6 9.9 0.0 2.1 1 1 0 1 1 1 0 Phospholipase/Carboxylesterase DLH PF01738.18 AAS51733.1 - 0.06 12.9 0.0 0.29 10.7 0.0 2.0 1 1 0 1 1 1 0 Dienelactone hydrolase family Peptidase_S15 PF02129.18 AAS51733.1 - 0.1 12.2 0.0 2.1 7.9 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF1749 PF08538.10 AAS51733.1 - 0.12 11.5 0.0 0.21 10.6 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) Zn_ribbon_17 PF17120.5 AAS51734.2 - 6.9e-11 41.6 1.8 1.4e-10 40.6 1.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AAS51734.2 - 3.3e-09 37.2 10.3 0.00027 21.6 0.2 5.5 5 0 0 5 5 5 2 WD domain, G-beta repeat zf-rbx1 PF12678.7 AAS51734.2 - 0.0032 17.7 6.5 0.0095 16.2 6.5 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AAS51734.2 - 0.0067 16.7 3.3 0.0067 16.7 3.3 2.1 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 AAS51734.2 - 0.04 13.8 3.8 0.04 13.8 0.5 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AAS51734.2 - 0.37 10.9 5.1 0.9 9.6 5.1 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AAS51734.2 - 2 8.3 8.5 0.38 10.6 4.2 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) MFS_1 PF07690.16 AAS51735.1 - 3.3e-22 78.9 36.8 4.1e-09 35.8 7.7 3.1 2 1 1 3 3 3 3 Major Facilitator Superfamily SURF4 PF02077.15 AAS51735.1 - 0.016 14.8 0.2 0.039 13.5 0.2 1.6 1 0 0 1 1 1 0 SURF4 family WD40 PF00400.32 AAS51736.1 - 9.3e-30 102.3 16.3 5.8e-06 27.0 1.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51736.1 - 2.6e-18 66.1 0.8 0.04 14.2 0.1 6.3 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS51736.1 - 5.8e-07 29.6 2.4 0.00071 19.5 1.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 AAS51736.1 - 3.7e-05 23.2 0.0 0.0029 17.0 0.0 2.1 1 1 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 AAS51736.1 - 4.3e-05 22.6 0.4 1.8 7.5 0.0 4.0 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein 6PF2K PF01591.18 AAS51737.1 - 1.4e-52 178.3 0.2 2e-52 177.7 0.2 1.1 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_33 PF13671.6 AAS51737.1 - 8e-06 26.1 0.0 1.3e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 AAS51737.1 - 7.7e-05 22.3 0.0 0.00014 21.4 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 AAS51737.1 - 0.0011 19.6 0.0 0.0018 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF3718 PF12514.8 AAS51737.1 - 0.024 14.8 0.1 0.072 13.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3718) AAA_16 PF13191.6 AAS51737.1 - 0.026 14.9 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Med7 PF05983.11 AAS51738.1 - 1.1e-63 214.7 1.2 1.3e-63 214.5 1.2 1.0 1 0 0 1 1 1 1 MED7 protein zf-rbx1 PF12678.7 AAS51739.2 - 2.6e-23 82.0 13.7 4.1e-23 81.4 13.7 1.3 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AAS51739.2 - 1e-16 60.8 10.6 1.3e-16 60.4 10.6 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 AAS51739.2 - 3.1e-06 27.4 13.6 0.00013 22.3 13.6 2.2 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS51739.2 - 0.00024 20.9 3.9 0.00024 20.9 3.9 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS51739.2 - 0.0018 18.1 12.4 0.0095 15.8 12.4 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AAS51739.2 - 0.0022 17.7 1.0 0.0022 17.7 1.0 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 AAS51739.2 - 0.79 9.8 9.1 3.6 7.7 9.2 2.0 1 1 0 1 1 1 0 RING-type zinc-finger FANCL_C PF11793.8 AAS51739.2 - 1.3 9.3 9.9 6.4 7.0 10.2 1.9 1 1 1 2 2 2 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 AAS51739.2 - 4 7.1 14.6 17 5.1 10.0 2.3 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AAS51739.2 - 4.4 7.3 11.4 22 5.1 11.4 2.1 1 1 0 1 1 1 0 zinc-RING finger domain PDT PF00800.18 AAS51740.1 - 2.2e-56 190.5 0.0 2.7e-56 190.3 0.0 1.1 1 0 0 1 1 1 1 Prephenate dehydratase NnrU PF07298.11 AAS51740.1 - 0.045 13.3 0.0 0.074 12.5 0.0 1.3 1 0 0 1 1 1 0 NnrU protein ATP11 PF06644.11 AAS51741.2 - 1.4e-88 297.3 0.5 1.6e-88 297.1 0.5 1.0 1 0 0 1 1 1 1 ATP11 protein DUF2115 PF09888.9 AAS51741.2 - 0.16 12.5 0.2 0.27 11.7 0.2 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) TSP_NTD PF17804.1 AAS51741.2 - 0.97 9.7 5.6 0.54 10.5 0.3 2.2 2 0 0 2 2 2 0 Tail specific protease N-terminal domain Myb_DNA-bind_5 PF13873.6 AAS51742.1 - 0.0094 16.0 0.2 0.017 15.2 0.2 1.4 1 0 0 1 1 1 1 Myb/SANT-like DNA-binding domain Sec16_C PF12931.7 AAS51742.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 Retrotrans_gag PF03732.17 AAS51742.1 - 0.33 11.2 2.6 21 5.5 0.3 2.4 2 0 0 2 2 2 0 Retrotransposon gag protein TPR_2 PF07719.17 AAS51743.2 - 8.4e-08 31.8 1.0 0.0056 16.7 0.0 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51743.2 - 1.5e-06 28.6 2.4 0.095 13.2 0.3 3.6 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS51743.2 - 3.4e-06 26.8 1.8 0.63 10.4 0.0 4.6 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51743.2 - 7.7e-06 26.3 2.3 3.2 8.8 0.0 6.1 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 AAS51743.2 - 0.00011 22.3 1.7 0.52 10.8 0.0 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51743.2 - 0.00023 21.4 8.5 0.024 14.9 0.1 4.6 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS51743.2 - 0.00043 20.0 4.4 0.15 11.9 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 AAS51743.2 - 0.00074 19.2 0.1 0.71 9.6 0.0 3.7 2 1 1 3 3 3 2 TPR repeat TPR_10 PF13374.6 AAS51743.2 - 0.0036 17.1 1.4 0.036 14.0 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_9 PF13371.6 AAS51743.2 - 0.0092 16.1 2.5 7.8 6.7 0.0 4.0 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS51743.2 - 0.029 15.0 3.3 12 6.6 0.0 4.5 4 1 0 5 5 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS51743.2 - 0.064 13.3 1.3 1.7 8.8 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat Coatomer_WDAD PF04053.14 AAS51743.2 - 0.16 11.0 0.2 0.29 10.1 0.2 1.3 1 0 0 1 1 1 0 Coatomer WD associated region RPA_C PF08784.11 AAS51744.1 - 9.5e-09 35.9 0.3 4.7e-08 33.6 0.0 2.2 2 1 1 3 3 3 1 Replication protein A C terminal tRNA_anti-codon PF01336.25 AAS51744.1 - 4.4e-07 29.8 0.2 7.5e-07 29.0 0.2 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AAS51744.1 - 0.018 14.8 1.0 0.024 14.3 0.1 1.6 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 Toxin_ToxA PF11584.8 AAS51744.1 - 0.038 14.0 0.1 0.067 13.2 0.1 1.5 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA Glyco_hydro_72 PF03198.14 AAS51745.1 - 4.4e-135 450.0 0.3 5.9e-135 449.6 0.3 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AAS51745.1 - 0.017 14.6 0.1 0.31 10.4 0.1 2.4 1 1 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Lipase_GDSL_2 PF13472.6 AAS51746.2 - 0.00066 20.1 0.0 0.0024 18.3 0.0 1.9 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family F-box_4 PF15966.5 AAS51746.2 - 0.015 15.2 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 F-box HTH_Tnp_Tc5 PF03221.16 AAS51746.2 - 0.13 12.3 0.1 0.3 11.2 0.1 1.5 1 0 0 1 1 1 0 Tc5 transposase DNA-binding domain zf-DNL PF05180.12 AAS51747.1 - 3.7e-31 106.8 1.0 6e-31 106.2 1.0 1.3 1 0 0 1 1 1 1 DNL zinc finger TFIIS_C PF01096.18 AAS51747.1 - 0.067 13.1 1.1 7.5 6.5 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) UPF0167 PF03691.14 AAS51747.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0167) HypA PF01155.19 AAS51747.1 - 0.12 12.4 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ZPR1 PF03367.13 AAS51747.1 - 0.12 12.2 1.7 0.28 11.0 1.5 1.6 1 1 0 1 1 1 0 ZPR1 zinc-finger domain zinc_ribbon_4 PF13717.6 AAS51747.1 - 0.7 9.9 4.5 3.1 7.8 0.1 2.3 1 1 1 2 2 2 0 zinc-ribbon domain CorA PF01544.18 AAS51749.1 - 6.9e-38 130.6 0.1 2.4e-36 125.6 0.1 2.1 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein Kri1_C PF12936.7 AAS51750.2 - 7.7e-32 109.3 4.0 7.7e-32 109.3 4.0 4.7 5 0 0 5 5 5 1 KRI1-like family C-terminal Kri1 PF05178.12 AAS51750.2 - 5.2e-14 52.7 10.9 5.2e-14 52.7 10.9 5.8 5 1 0 5 5 5 1 KRI1-like family UPF0220 PF05255.11 AAS51751.1 - 9.4e-65 217.2 1.6 1.1e-64 217.0 1.6 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0220) DUF3040 PF11239.8 AAS51751.1 - 3.9 7.8 6.4 0.88 9.9 0.9 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3040) Pkinase PF00069.25 AAS51752.1 - 1.5e-58 198.3 0.0 1.8e-58 198.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51752.1 - 7.2e-30 104.1 0.0 9.5e-30 103.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51752.1 - 2.9e-07 30.1 0.0 4.6e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AAS51752.1 - 0.00088 18.7 0.0 0.0014 18.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS51752.1 - 0.0012 18.8 0.0 0.0023 17.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AAS51752.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Ribosomal_S11 PF00411.19 AAS51753.1 - 1.4e-06 28.7 0.0 3.4e-06 27.4 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein S11 Ribosomal_L23eN PF03939.13 AAS51754.1 - 8.6e-20 70.7 9.9 8.6e-20 70.7 9.9 2.0 2 0 0 2 2 2 1 Ribosomal protein L23, N-terminal domain Ribosomal_L23 PF00276.20 AAS51754.1 - 4.2e-16 59.1 8.0 5.2e-16 58.8 3.4 2.8 2 1 0 2 2 2 1 Ribosomal protein L23 Hydant_A_N PF05378.13 AAS51754.1 - 0.055 13.2 1.1 0.08 12.6 1.1 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase N-terminal region Phage_holin_2_2 PF10746.9 AAS51755.2 - 0.19 11.4 7.1 0.25 11.0 0.5 3.2 3 0 0 3 3 3 0 Phage holin T7 family, holin superfamily II CbtB PF09489.10 AAS51755.2 - 8.5 6.6 8.1 8.9 6.5 0.0 3.4 3 1 1 4 4 4 0 Probable cobalt transporter subunit (CbtB) Ldh_1_N PF00056.23 AAS51756.1 - 4.9e-39 133.6 0.6 9.8e-39 132.7 0.6 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AAS51756.1 - 1.3e-37 129.3 0.0 4.5e-37 127.6 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain THF_DHG_CYH_C PF02882.19 AAS51756.1 - 0.011 15.0 1.1 1.2 8.4 1.1 2.2 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain TRM13 PF05206.14 AAS51757.2 - 3.2e-76 256.3 0.0 7.7e-76 255.1 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase TRM13 zf-TRM13_CCCH PF11722.8 AAS51757.2 - 1.4e-12 47.1 1.9 2.5e-12 46.3 1.1 1.9 2 0 0 2 2 2 1 CCCH zinc finger in TRM13 protein zf-U11-48K PF05253.12 AAS51757.2 - 1.5e-08 34.3 0.6 1.5e-08 34.3 0.6 2.2 2 0 0 2 2 2 1 U11-48K-like CHHC zinc finger Methyltransf_32 PF13679.6 AAS51757.2 - 0.047 13.7 1.5 8.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Ras PF00071.22 AAS51758.2 - 1.9e-32 112.1 0.2 3.7e-28 98.2 0.1 2.3 2 0 0 2 2 2 2 Ras family Roc PF08477.13 AAS51758.2 - 1.1e-17 64.4 0.0 1.5e-12 47.7 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS51758.2 - 1.2e-06 28.1 0.0 1.6e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS51758.2 - 0.0004 19.8 0.2 0.0044 16.4 0.2 2.1 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 AAS51758.2 - 0.0032 17.0 0.0 0.0065 16.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_5 PF07728.14 AAS51758.2 - 0.023 14.7 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Rad17 PF03215.15 AAS51758.2 - 0.028 14.3 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 AAS51758.2 - 0.047 14.1 0.0 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 AAS51758.2 - 0.08 13.2 0.0 0.2 11.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain Ubiquitin_3 PF14836.6 AAS51758.2 - 0.12 12.4 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-like domain UPF0020 PF01170.18 AAS51759.1 - 5.8e-10 39.2 0.0 2.3e-08 34.0 0.0 2.2 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 BRCT PF00533.26 AAS51759.1 - 0.027 14.9 0.0 0.054 13.9 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain MethyltransfD12 PF02086.15 AAS51759.1 - 0.039 13.6 0.0 4.2 7.0 0.0 2.5 2 0 0 2 2 2 0 D12 class N6 adenine-specific DNA methyltransferase N6_Mtase PF02384.16 AAS51759.1 - 0.12 11.6 0.0 0.29 10.3 0.0 1.5 2 0 0 2 2 2 0 N-6 DNA Methylase RRM_1 PF00076.22 AAS51760.2 - 2e-34 117.2 0.1 5.2e-17 61.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS51760.2 - 8.4e-11 41.9 0.1 6.6e-05 23.0 0.0 3.0 2 1 0 2 2 2 2 RNA recognition motif RRM_5 PF13893.6 AAS51760.2 - 0.011 15.3 0.0 0.026 14.1 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AAS51760.2 - 0.093 12.8 0.1 0.94 9.6 0.0 2.4 2 0 0 2 2 2 0 RNA binding motif PHM7_cyt PF14703.6 AAS51760.2 - 0.26 11.5 4.2 0.56 10.4 0.1 2.8 3 0 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter TFIIA PF03153.13 AAS51760.2 - 0.33 10.9 30.2 0.81 9.6 13.5 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1451 PF07295.11 AAS51760.2 - 0.35 10.9 3.3 0.17 11.9 0.4 1.9 2 0 0 2 2 2 0 Zinc-ribbon containing domain DUF4199 PF13858.6 AAS51760.2 - 7 7.0 16.2 0.86 10.0 7.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Nramp PF01566.18 AAS51761.1 - 1.2e-84 284.3 20.5 4.5e-83 279.2 20.5 2.1 1 1 0 1 1 1 1 Natural resistance-associated macrophage protein DUF1576 PF07613.11 AAS51761.1 - 0.53 9.8 9.1 0.091 12.3 2.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1576) Ribosomal_S19e PF01090.19 AAS51762.1 - 6.4e-55 184.6 0.0 7.1e-55 184.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e Ribosomal_L18 PF17135.4 AAS51763.1 - 2.6e-83 278.0 2.8 2.9e-83 277.9 2.8 1.0 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AAS51763.1 - 0.008 16.9 0.2 0.026 15.2 0.2 2.0 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A NAC PF01849.18 AAS51763.1 - 0.012 15.5 0.0 0.14 12.1 0.0 2.3 2 1 0 2 2 2 0 NAC domain Secretin_N PF03958.17 AAS51763.1 - 0.11 12.9 0.1 0.23 11.9 0.1 1.6 1 1 0 1 1 1 0 Bacterial type II/III secretion system short domain Nudc_N PF14050.6 AAS51763.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.5 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. MFS_1 PF07690.16 AAS51764.2 - 2.6e-30 105.6 39.1 2.6e-30 105.6 39.1 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_2 PF13347.6 AAS51764.2 - 5.3e-05 22.0 15.0 5.3e-05 22.0 15.0 3.2 1 1 2 3 3 3 2 MFS/sugar transport protein Sugar_tr PF00083.24 AAS51764.2 - 0.00047 19.2 18.6 0.00047 19.2 18.6 3.8 2 2 0 2 2 2 1 Sugar (and other) transporter Myc_target_1 PF15179.6 AAS51764.2 - 0.025 14.5 0.5 0.048 13.6 0.5 1.4 1 0 0 1 1 1 0 Myc target protein 1 DUF2606 PF10794.9 AAS51764.2 - 0.19 11.5 0.3 0.39 10.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) SPC25 PF06703.11 AAS51764.2 - 7.5 6.3 5.9 7.4 6.3 1.2 2.5 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) MFS_1 PF07690.16 AAS51765.1 - 2.1e-26 92.7 34.0 2.1e-26 92.7 34.0 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Myc_target_1 PF15179.6 AAS51765.1 - 0.07 13.0 0.8 0.13 12.1 0.8 1.4 1 0 0 1 1 1 0 Myc target protein 1 DUF2606 PF10794.9 AAS51765.1 - 0.12 12.1 0.3 0.28 11.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) SPC25 PF06703.11 AAS51765.1 - 0.85 9.4 2.7 2.8 7.7 0.8 2.5 1 1 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Redoxin PF08534.10 AAS51766.1 - 2.9e-32 111.4 0.0 3.4e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin Lambda_tail_I PF06805.12 AAS51766.1 - 0.077 13.3 0.1 0.26 11.6 0.0 1.9 2 0 0 2 2 2 0 Bacteriophage lambda tail assembly protein I PD-C2-AF1 PF09310.10 AAS51767.1 - 0.13 11.6 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 POU domain, class 2, associating factor 1 GCR1_C PF12550.8 AAS51768.1 - 1.3e-23 83.1 0.0 2.5e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Fib_alpha PF08702.10 AAS51768.1 - 0.068 13.4 0.6 0.13 12.5 0.6 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TDA11 PF17084.5 AAS51770.2 - 7.5e-21 74.6 14.3 8.6e-10 38.1 4.6 4.8 1 1 3 4 4 4 3 Topoisomerase I damage affected protein 11 Kelch_5 PF13854.6 AAS51771.2 - 2.3e-32 110.4 4.5 8e-06 25.7 0.1 6.4 6 0 0 6 6 6 6 Kelch motif Kelch_3 PF13415.6 AAS51771.2 - 3.1e-26 91.1 1.8 1.9e-05 24.8 0.0 5.8 5 0 0 5 5 5 5 Galactose oxidase, central domain Kelch_4 PF13418.6 AAS51771.2 - 3.3e-26 91.1 4.6 0.00013 21.9 0.1 6.4 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_6 PF13964.6 AAS51771.2 - 1.9e-21 75.5 5.4 0.0001 22.5 0.2 6.5 4 1 2 6 6 6 4 Kelch motif Kelch_1 PF01344.25 AAS51771.2 - 1.1e-16 60.2 2.0 1.1e-05 24.9 0.1 5.6 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 AAS51771.2 - 5.9e-10 38.7 5.4 0.12 12.4 0.0 6.1 6 0 0 6 6 6 3 Kelch motif Spc7 PF08317.11 AAS51771.2 - 0.0051 15.7 31.5 0.04 12.8 13.6 2.7 2 0 0 2 2 2 2 Spc7 kinetochore protein XLF PF09302.11 AAS51771.2 - 0.058 13.6 10.6 0.087 13.0 8.8 2.2 2 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component IFT57 PF10498.9 AAS51771.2 - 0.22 10.5 30.9 0.022 13.8 3.9 3.0 3 0 0 3 3 3 0 Intra-flagellar transport protein 57 DUF4201 PF13870.6 AAS51771.2 - 0.79 9.4 32.4 0.89 9.3 12.6 3.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4201) FUSC PF04632.12 AAS51771.2 - 2.5 6.5 4.0 1.2 7.5 1.5 1.6 2 0 0 2 2 2 0 Fusaric acid resistance protein family GIT_CC PF16559.5 AAS51771.2 - 4.3 7.3 17.8 1.5 8.7 0.3 4.2 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor PCRF PF03462.18 AAS51771.2 - 7.7 6.3 16.2 5.3 6.9 5.3 2.8 2 0 0 2 2 2 0 PCRF domain ApoO PF09769.9 AAS51774.1 - 5.8e-33 113.6 0.2 4e-32 110.9 0.1 2.0 2 0 0 2 2 2 1 Apolipoprotein O RTT107_BRCT_6 PF16771.5 AAS51775.1 - 1.3e-39 134.9 1.4 2.3e-39 134.1 0.1 2.2 2 0 0 2 2 1 1 Regulator of Ty1 transposition protein 107 BRCT domain RTT107_BRCT_5 PF16770.5 AAS51775.1 - 1.1e-24 86.2 0.0 6e-22 77.4 0.0 3.9 4 0 0 4 4 4 1 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 AAS51775.1 - 2.9e-22 78.4 1.2 1.6e-15 56.8 0.1 4.1 4 0 0 4 4 4 2 twin BRCT domain BRCT PF00533.26 AAS51775.1 - 3.1e-20 72.3 3.2 1.6e-06 28.4 0.1 6.3 6 1 0 6 6 6 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AAS51775.1 - 6.1e-13 49.0 0.1 0.002 18.5 0.0 5.2 4 0 0 4 4 4 4 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 AAS51775.1 - 0.00011 22.5 6.5 0.016 15.5 0.0 5.0 6 0 0 6 6 6 1 DNA ligase 3 BRCT domain RQC PF09382.10 AAS51775.1 - 0.16 11.7 0.0 0.73 9.6 0.0 2.0 2 0 0 2 2 2 0 RQC domain Hamartin PF04388.12 AAS51775.1 - 0.52 8.9 12.2 0.73 8.4 12.2 1.1 1 0 0 1 1 1 0 Hamartin protein SOG2 PF10428.9 AAS51775.1 - 0.66 9.1 17.5 0.9 8.7 17.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MTBP_C PF14920.6 AAS51775.1 - 1 9.0 15.4 1.8 8.2 15.4 1.3 1 0 0 1 1 1 0 MDM2-binding Ndc1_Nup PF09531.10 AAS51775.1 - 4.6 5.8 6.8 7.2 5.2 6.8 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 AAS51775.1 - 5.7 5.4 14.9 7.9 4.9 14.9 1.1 1 0 0 1 1 1 0 Macoilin family Cir_N PF10197.9 AAS51776.1 - 6.8e-06 26.2 1.5 6.8e-06 26.2 1.5 2.1 2 0 0 2 2 2 1 N-terminal domain of CBF1 interacting co-repressor CIR Ank_2 PF12796.7 AAS51777.2 - 2.8e-31 107.9 4.2 2.9e-12 47.0 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AAS51777.2 - 5.2e-22 77.9 1.0 1.6e-05 25.4 0.1 4.7 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 AAS51777.2 - 8e-20 70.6 6.3 0.00064 20.0 0.0 5.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 AAS51777.2 - 6.4e-19 67.5 4.3 0.0002 21.6 0.1 6.6 6 0 0 6 6 6 4 Ankyrin repeat SPX PF03105.19 AAS51777.2 - 6.1e-18 65.9 17.8 3.1e-10 40.6 1.7 3.2 1 1 2 3 3 3 3 SPX domain Ank_3 PF13606.6 AAS51777.2 - 7e-16 56.7 5.0 0.0019 18.5 0.0 6.9 7 0 0 7 7 7 3 Ankyrin repeat Ank_2 PF12796.7 AAS51778.2 - 1.9e-30 105.3 1.3 7.7e-09 36.0 0.1 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_3 PF13606.6 AAS51778.2 - 4.9e-27 91.0 1.3 0.00084 19.6 0.0 7.0 7 0 0 7 7 7 6 Ankyrin repeat Ank_4 PF13637.6 AAS51778.2 - 1.2e-24 86.3 2.4 5e-08 33.3 0.1 5.7 2 1 4 6 6 6 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 AAS51778.2 - 2.7e-23 81.7 4.0 6.6e-06 26.3 0.0 4.6 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 AAS51778.2 - 5.1e-22 77.3 2.4 7.5e-06 26.2 0.0 6.5 7 0 0 7 7 7 3 Ankyrin repeat Band_7 PF01145.25 AAS51779.1 - 2.3e-22 79.8 0.8 3.3e-22 79.4 0.8 1.2 1 0 0 1 1 1 1 SPFH domain / Band 7 family Spo12 PF05032.12 AAS51780.2 - 9.4e-18 63.8 1.8 9.4e-18 63.8 1.8 1.9 2 0 0 2 2 2 1 Spo12 family LUC7 PF03194.15 AAS51780.2 - 0.12 12.0 3.5 0.17 11.5 0.0 2.0 2 0 0 2 2 2 0 LUC7 N_terminus SMI1_KNR4 PF09346.10 AAS51781.2 - 7.8e-33 113.7 0.0 3e-32 111.8 0.0 2.1 2 1 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) Ribosomal_S13_N PF08069.12 AAS51781.2 - 0.17 12.0 1.0 0.35 10.9 0.1 2.1 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain DIE2_ALG10 PF04922.12 AAS51782.2 - 6.7e-108 361.5 31.9 9.2e-108 361.0 31.9 1.2 1 0 0 1 1 1 1 DIE2/ALG10 family Lectin_C PF00059.21 AAS51783.2 - 0.00075 20.2 0.1 0.018 15.8 0.2 2.3 2 0 0 2 2 2 1 Lectin C-type domain Pex24p PF06398.11 AAS51784.1 - 5.8e-81 272.3 0.7 8.1e-81 271.8 0.7 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin NAAA-beta PF15508.6 AAS51784.1 - 0.0095 16.2 0.0 0.025 14.9 0.0 1.7 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Herpes_LMP1 PF05297.11 AAS51784.1 - 1.4 8.0 4.4 1 8.5 0.2 2.0 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) WD40 PF00400.32 AAS51785.2 - 1.2e-09 38.6 8.0 0.065 14.1 0.1 6.3 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51785.2 - 0.00016 21.9 0.0 6 7.2 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS51785.2 - 0.15 11.4 0.0 11 5.2 0.0 2.5 2 0 0 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 AAS51786.1 - 0.024 15.0 0.0 2.5 8.5 0.0 2.7 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS51786.1 - 0.027 15.3 0.0 1.7 9.6 0.0 3.1 2 0 0 2 2 2 0 WD domain, G-beta repeat RRM_1 PF00076.22 AAS51787.2 - 0.062 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SKG6 PF08693.10 AAS51788.2 - 0.0029 17.0 7.7 0.0052 16.2 7.7 1.3 1 0 0 1 1 1 1 Transmembrane alpha-helix domain Ribosomal_S4 PF00163.19 AAS51789.1 - 7.6e-12 46.0 3.8 1.1e-11 45.4 3.5 1.5 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 AAS51789.1 - 1.1e-11 44.3 0.0 1.9e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 S4 domain Ribosomal_L6 PF00347.23 AAS51790.2 - 2.3e-16 60.2 0.0 5.4e-07 30.2 0.0 2.3 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_L3 PF00297.22 AAS51791.2 - 2.6e-17 62.9 1.9 8.1e-15 54.7 0.4 2.2 1 1 1 2 2 2 2 Ribosomal protein L3 CRM1_C PF08767.11 AAS51792.2 - 2.3e-133 444.3 3.0 2.3e-133 444.3 3.0 3.1 3 1 0 3 3 3 1 CRM1 C terminal Xpo1 PF08389.12 AAS51792.2 - 3.1e-37 127.9 6.3 3.1e-37 127.9 6.3 3.3 3 0 0 3 3 3 1 Exportin 1-like protein CRM1_repeat_2 PF18784.1 AAS51792.2 - 5.5e-32 109.2 1.9 1.6e-31 107.7 1.9 1.9 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 AAS51792.2 - 1.1e-29 102.3 0.3 9.2e-29 99.3 0.3 2.8 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 AAS51792.2 - 4.1e-16 58.2 0.6 4.1e-16 58.2 0.6 2.0 2 0 0 2 2 2 1 Chromosome region maintenance or exportin repeat IBN_N PF03810.19 AAS51792.2 - 9.5e-15 54.3 0.6 4.9e-13 48.8 0.0 3.3 2 0 0 2 2 2 1 Importin-beta N-terminal domain DUF3385 PF11865.8 AAS51792.2 - 0.0036 17.2 0.5 0.2 11.5 0.0 3.7 2 1 1 3 3 3 1 Domain of unknown function (DUF3385) Symplekin_C PF12295.8 AAS51792.2 - 0.02 15.0 6.0 0.51 10.4 0.0 4.9 5 2 0 5 5 5 0 Symplekin tight junction protein C terminal V-ATPase_H_C PF11698.8 AAS51792.2 - 0.16 12.1 3.4 1.3 9.2 0.2 3.7 3 0 0 3 3 3 0 V-ATPase subunit H DUF507 PF04368.13 AAS51792.2 - 4.5 7.2 7.3 3.3 7.6 0.3 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF507) Ribosomal_L2_C PF03947.18 AAS51793.1 - 6.2e-44 149.2 3.5 1.1e-43 148.4 3.5 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AAS51793.1 - 1.5e-13 50.5 0.1 4.1e-13 49.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain RRM_1 PF00076.22 AAS51794.1 - 9.3e-20 70.2 0.0 8.9e-11 41.5 0.0 2.8 2 2 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS51794.1 - 1.9e-06 27.6 0.0 0.00012 21.9 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AAS51794.1 - 0.01 15.9 0.0 0.24 11.5 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif Ribosomal_L29e PF01779.17 AAS51795.1 - 2.3e-21 75.8 11.4 3.1e-21 75.4 11.4 1.2 1 0 0 1 1 1 1 Ribosomal L29e protein family UCR_hinge PF02320.16 AAS51796.1 - 6.6e-26 90.3 5.7 6.6e-26 90.3 5.7 1.6 2 0 0 2 2 2 1 Ubiquinol-cytochrome C reductase hinge protein DNA_pol_phi PF04931.13 AAS51796.1 - 0.0065 14.6 18.1 0.0063 14.7 18.1 1.1 1 0 0 1 1 1 1 DNA polymerase phi Sigma70_ner PF04546.13 AAS51796.1 - 0.0068 16.3 11.2 0.0087 16.0 11.2 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region RPN2_C PF18004.1 AAS51796.1 - 0.0098 15.8 3.7 0.013 15.4 3.7 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain GCIP PF13324.6 AAS51796.1 - 0.024 14.2 9.3 0.028 14.1 9.3 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PRP38_assoc PF12871.7 AAS51796.1 - 0.025 15.2 12.8 0.036 14.7 12.8 1.2 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Nop14 PF04147.12 AAS51796.1 - 0.038 12.2 14.6 0.043 12.0 14.6 1.0 1 0 0 1 1 1 0 Nop14-like family Erythro_esteras PF05139.14 AAS51796.1 - 0.046 13.5 3.8 0.049 13.4 3.8 1.1 1 0 0 1 1 1 0 Erythromycin esterase RRN3 PF05327.11 AAS51796.1 - 0.12 10.9 9.7 0.12 10.9 9.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cwf_Cwc_15 PF04889.12 AAS51796.1 - 0.12 12.1 13.0 0.13 12.0 13.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PDDEXK_6 PF04720.12 AAS51796.1 - 0.22 11.4 4.7 0.25 11.2 4.7 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function CDC45 PF02724.14 AAS51796.1 - 0.22 9.7 13.9 0.24 9.6 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 AAS51796.1 - 0.23 10.4 2.0 0.25 10.3 2.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) D123 PF07065.14 AAS51796.1 - 0.33 10.1 4.9 0.37 9.9 4.9 1.2 1 0 0 1 1 1 0 D123 BUD22 PF09073.10 AAS51796.1 - 0.42 9.9 9.4 0.41 9.9 9.4 1.0 1 0 0 1 1 1 0 BUD22 Fmp27 PF10344.9 AAS51796.1 - 0.44 8.6 2.4 0.49 8.4 2.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 FAM176 PF14851.6 AAS51796.1 - 0.48 10.1 10.8 0.69 9.6 10.8 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 AAS51796.1 - 0.57 10.2 7.4 0.71 9.9 7.4 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal SDA1 PF05285.12 AAS51796.1 - 0.66 9.3 14.0 0.69 9.3 14.0 1.1 1 0 0 1 1 1 0 SDA1 TRAP_alpha PF03896.16 AAS51796.1 - 0.74 9.0 10.3 0.83 8.8 10.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Merozoite_SPAM PF07133.11 AAS51796.1 - 0.85 9.6 22.7 1 9.3 22.7 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Paf1 PF03985.13 AAS51796.1 - 1 8.3 13.5 1.3 7.9 13.5 1.2 1 0 0 1 1 1 0 Paf1 Nop53 PF07767.11 AAS51796.1 - 1.3 8.3 12.1 1.7 8.0 12.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NOA36 PF06524.12 AAS51796.1 - 1.6 8.0 16.4 2.2 7.5 16.4 1.3 1 0 0 1 1 1 0 NOA36 protein Radial_spoke PF04712.12 AAS51796.1 - 1.6 7.6 12.0 1.9 7.4 12.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein DUF4637 PF15470.6 AAS51796.1 - 2 8.1 13.4 2.9 7.6 13.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3381 PF11861.8 AAS51796.1 - 2.3 8.0 13.3 1.8 8.3 11.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Na_trans_assoc PF06512.13 AAS51796.1 - 2.4 8.4 12.7 2.8 8.2 12.7 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Drc1-Sld2 PF11719.8 AAS51796.1 - 2.7 7.4 7.0 2.9 7.4 7.0 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein Sporozoite_P67 PF05642.11 AAS51796.1 - 3 5.8 7.1 3 5.8 7.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PTPRCAP PF15713.5 AAS51796.1 - 3.2 8.0 15.0 4 7.7 15.0 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated YL1 PF05764.13 AAS51796.1 - 3.4 7.7 16.8 3.7 7.6 16.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein HLH PF00010.26 AAS51797.3 - 2.6e-13 49.7 0.3 2.6e-13 49.7 0.3 2.3 3 0 0 3 3 3 1 Helix-loop-helix DNA-binding domain DUF4602 PF15375.6 AAS51798.1 - 6.2e-05 23.3 10.2 0.00025 21.4 7.7 3.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4602) CDC45 PF02724.14 AAS51798.1 - 0.53 8.5 7.6 0.73 8.0 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein CCDC53 PF10152.9 AAS51798.1 - 0.55 10.6 5.3 1.8 9.0 5.3 2.0 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex AF-4 PF05110.13 AAS51798.1 - 4.5 5.2 13.9 6.8 4.6 13.9 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein rRNA_processing PF08524.11 AAS51798.1 - 7.7 6.5 8.1 6.3 6.8 0.7 2.3 2 0 0 2 2 2 0 rRNA processing His_biosynth PF00977.21 AAS51799.1 - 2.2e-24 86.2 0.0 2.8e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein RNA_pol_A_bac PF01000.26 AAS51800.1 - 1.3e-31 109.2 0.2 3.4e-31 107.9 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AAS51800.1 - 2.5e-19 68.5 0.0 3.3e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Tim44 PF04280.15 AAS51802.1 - 3.9e-37 127.6 0.0 9e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 Tim44-like domain DUF3668 PF12416.8 AAS51802.1 - 0.053 13.3 0.0 0.1 12.4 0.0 1.4 1 0 0 1 1 1 0 Cep120 protein Spore_III_AB PF09548.10 AAS51802.1 - 0.092 12.9 1.3 0.32 11.1 0.2 2.4 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) Op_neuropeptide PF08035.11 AAS51802.1 - 0.25 11.2 1.8 9.4 6.2 0.6 2.4 2 0 0 2 2 2 0 Opioids neuropeptide PRKG1_interact PF15898.5 AAS51802.1 - 5.4 8.0 9.7 0.58 11.1 0.7 2.7 1 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain Ribosomal_S18 PF01084.20 AAS51803.1 - 1.9e-16 60.0 0.0 7.8e-15 54.8 0.0 2.4 2 0 0 2 2 2 2 Ribosomal protein S18 BCDHK_Adom3 PF10436.9 AAS51804.1 - 8.6e-21 74.5 0.4 1.2e-20 73.9 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AAS51804.1 - 3.4e-15 56.5 0.0 7.4e-15 55.4 0.0 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AAS51804.1 - 0.00016 21.5 0.0 0.00025 20.9 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.6 AAS51804.1 - 0.17 11.8 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain BAR_2 PF10455.9 AAS51805.1 - 3.4e-72 243.0 13.9 3.4e-72 243.0 13.9 1.9 2 1 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AAS51805.1 - 4.3e-14 52.7 11.8 4.3e-14 52.7 11.8 2.5 1 1 1 2 2 2 1 BAR domain Glyco_hydro_20 PF00728.22 AAS51805.1 - 0.0017 17.8 0.2 0.0043 16.5 0.2 1.7 1 1 1 2 2 2 1 Glycosyl hydrolase family 20, catalytic domain TcpS PF17456.2 AAS51805.1 - 0.081 13.0 0.3 0.19 11.8 0.3 1.8 1 0 0 1 1 1 0 Toxin-coregulated pilus protein S Atg14 PF10186.9 AAS51805.1 - 0.46 9.5 14.1 0.096 11.7 3.0 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3106 PF11304.8 AAS51805.1 - 3.6 8.1 12.9 0.61 10.6 1.6 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) ACCA PF03255.14 AAS51805.1 - 5.8 6.8 11.3 0.18 11.7 1.4 2.9 2 2 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ofd1_CTDD PF10637.9 AAS51806.2 - 7.8e-90 300.7 0.7 2.7e-89 298.9 0.5 1.8 2 0 0 2 2 2 1 Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 PF13661.6 AAS51806.2 - 1.4e-27 96.2 0.0 4.5e-27 94.6 0.0 1.9 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 AAS51806.2 - 2.1e-14 54.2 0.1 1.3e-13 51.7 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 AAS51806.2 - 0.054 14.0 0.1 0.15 12.5 0.1 1.8 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Lge1 PF11488.8 AAS51806.2 - 1.5 9.1 6.2 25 5.1 1.7 3.0 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 Complex1_LYR PF05347.15 AAS51807.1 - 1.7e-14 53.6 1.3 2.3e-14 53.2 1.3 1.2 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 AAS51807.1 - 0.00053 20.7 3.3 0.00062 20.5 3.3 1.2 1 0 0 1 1 1 1 Complex1_LYR-like Complex1_LYR_1 PF13232.6 AAS51807.1 - 0.0019 18.8 0.3 0.0029 18.2 0.3 1.4 1 0 0 1 1 1 1 Complex1_LYR-like TENA_THI-4 PF03070.16 AAS51807.1 - 0.01 15.7 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 0 TENA/THI-4/PQQC family DnaJ-X PF14308.6 AAS51809.2 - 1.7e-51 174.6 4.3 2.9e-51 173.9 4.3 1.3 1 0 0 1 1 1 1 X-domain of DnaJ-containing DnaJ PF00226.31 AAS51809.2 - 5.3e-25 87.3 5.0 8.1e-25 86.7 2.0 2.5 2 0 0 2 2 2 1 DnaJ domain DUF3939 PF13075.6 AAS51809.2 - 0.0042 17.1 0.2 0.0072 16.4 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3939) DUF848 PF05852.11 AAS51809.2 - 0.83 9.8 5.8 0.72 10.0 3.2 2.0 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Metallophos PF00149.28 AAS51810.1 - 0.0011 19.6 8.3 0.0028 18.2 8.3 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase AAA PF00004.29 AAS51811.2 - 2.7e-38 131.4 0.0 4.8e-38 130.6 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS51811.2 - 2.2e-07 30.6 0.0 5.4e-07 29.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 AAS51811.2 - 3.1e-06 27.1 0.0 9.1e-06 25.6 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 AAS51811.2 - 4.4e-05 23.8 0.1 0.00059 20.1 0.1 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AAS51811.2 - 7.5e-05 22.5 0.0 0.00015 21.6 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 AAS51811.2 - 0.00031 20.7 0.1 0.0012 18.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS51811.2 - 0.00049 20.5 0.4 0.0029 18.0 0.1 2.5 2 1 0 2 2 1 1 AAA ATPase domain AAA_2 PF07724.14 AAS51811.2 - 0.00054 20.1 0.0 0.00096 19.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 AAS51811.2 - 0.00087 18.6 0.0 0.0016 17.7 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain ABC_tran PF00005.27 AAS51811.2 - 0.0025 18.4 0.0 0.0067 16.9 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 AAS51811.2 - 0.0027 17.3 0.0 0.29 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AAS51811.2 - 0.0047 16.3 0.1 0.0095 15.3 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AAS51811.2 - 0.0062 16.3 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 AAS51811.2 - 0.0064 15.7 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_33 PF13671.6 AAS51811.2 - 0.0073 16.5 0.0 0.018 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS51811.2 - 0.0078 16.8 0.0 0.025 15.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AAS51811.2 - 0.024 14.7 0.0 0.055 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 AAS51811.2 - 0.034 13.6 0.0 4.7 6.6 0.0 2.4 1 1 0 2 2 2 0 Bacterial TniB protein AAA_28 PF13521.6 AAS51811.2 - 0.089 13.0 0.6 0.4 10.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 AAS51811.2 - 0.099 12.4 0.0 0.25 11.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AAS51811.2 - 0.13 12.0 0.0 0.35 10.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 AAS51811.2 - 0.13 11.7 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Chromo PF00385.24 AAS51811.2 - 0.16 11.9 0.0 0.36 10.8 0.0 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain NACHT PF05729.12 AAS51811.2 - 0.17 11.8 0.0 0.36 10.7 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 AAS51811.2 - 0.18 11.3 0.0 0.32 10.5 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Not3 PF04065.15 AAS51812.2 - 3.3e-80 268.9 21.3 3.3e-80 268.9 21.3 1.7 2 0 0 2 2 2 1 Not1 N-terminal domain, CCR4-Not complex component NOT2_3_5 PF04153.18 AAS51812.2 - 1.4e-21 76.9 0.2 1.4e-21 76.9 0.2 2.0 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Syntaxin_2 PF14523.6 AAS51812.2 - 0.004 17.5 1.9 0.004 17.5 1.9 2.7 2 0 0 2 2 2 1 Syntaxin-like protein Ribosomal_S18 PF01084.20 AAS51812.2 - 1.8 8.9 3.7 1.2 9.4 0.8 2.3 2 0 0 2 2 2 0 Ribosomal protein S18 CLZ PF16526.5 AAS51812.2 - 5 7.5 11.1 0.28 11.6 1.6 3.6 3 2 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels KOW PF00467.29 AAS51815.2 - 0.075 13.0 0.0 0.22 11.5 0.0 1.8 2 0 0 2 2 2 0 KOW motif bZIP_1 PF00170.21 AAS51816.2 - 6.9e-16 58.1 8.4 9.6e-16 57.6 8.4 1.2 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 AAS51816.2 - 2.9e-07 30.5 8.1 4.8e-07 29.7 8.1 1.3 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_Maf PF03131.17 AAS51816.2 - 0.009 16.5 4.0 0.016 15.8 4.0 1.3 1 0 0 1 1 1 1 bZIP Maf transcription factor HAUS6_N PF14661.6 AAS51816.2 - 0.083 12.5 0.1 0.1 12.2 0.1 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Elf4 PF07011.11 AAS51816.2 - 0.09 12.7 0.2 0.14 12.1 0.2 1.2 1 0 0 1 1 1 0 Early Flowering 4 domain MSA-2c PF12238.8 AAS51817.2 - 0.1 12.6 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Merozoite surface antigen 2c Pkinase PF00069.25 AAS51818.1 - 9e-59 199.0 8.3 7.5e-53 179.6 1.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51818.1 - 4.6e-18 65.4 2.6 2.4e-13 50.0 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 AAS51818.1 - 4.6e-07 30.0 0.1 1.5e-05 25.1 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AAS51818.1 - 0.0042 15.9 0.1 0.015 14.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AAS51818.1 - 0.012 15.0 0.3 0.025 13.9 0.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AAS51818.1 - 0.032 13.8 0.8 0.075 12.6 0.1 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase DUF496 PF04363.12 AAS51818.1 - 0.57 10.3 4.3 0.55 10.3 0.8 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF496) F_actin_cap_B PF01115.17 AAS51819.1 - 2.8e-86 289.0 0.0 3.3e-86 288.8 0.0 1.0 1 0 0 1 1 1 1 F-actin capping protein, beta subunit Erg28 PF03694.13 AAS51820.1 - 3.2e-44 149.8 0.9 4.1e-44 149.5 0.9 1.1 1 0 0 1 1 1 1 Erg28 like protein cNMP_binding PF00027.29 AAS51821.1 - 1.5e-41 140.3 0.2 4.6e-22 77.9 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain RIIa PF02197.17 AAS51821.1 - 2.2e-09 36.8 2.6 6.1e-09 35.4 2.6 1.8 1 0 0 1 1 1 1 Regulatory subunit of type II PKA R-subunit SNF2_N PF00176.23 AAS51822.1 - 1.4e-63 214.8 0.2 2.7e-63 213.8 0.2 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS51822.1 - 1.5e-19 70.4 0.1 7.8e-19 68.1 0.0 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51822.1 - 1.5e-09 38.1 0.0 5e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS51822.1 - 0.00013 21.2 0.0 0.00039 19.7 0.0 1.7 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AAS51822.1 - 0.00019 21.2 0.0 0.00046 20.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase E1_UFD PF09358.10 AAS51822.1 - 0.091 13.5 0.2 0.4 11.4 0.2 2.1 1 0 0 1 1 1 0 Ubiquitin fold domain MobA_MobL PF03389.15 AAS51822.1 - 0.13 11.9 1.1 0.45 10.2 0.1 2.1 2 0 0 2 2 2 0 MobA/MobL family LPP20 PF02169.16 AAS51822.1 - 0.52 10.7 2.0 0.69 10.3 0.1 2.2 2 0 0 2 2 2 0 LPP20 lipoprotein SWIRM PF04433.17 AAS51823.2 - 8.6e-28 96.5 0.4 2e-27 95.3 0.4 1.7 1 0 0 1 1 1 1 SWIRM domain ZZ PF00569.17 AAS51823.2 - 2.4e-11 43.3 2.0 3.7e-11 42.7 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM-assoc_1 PF16495.5 AAS51823.2 - 2.8e-10 40.0 2.5 2.8e-10 40.0 2.5 2.1 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 AAS51823.2 - 6.9e-09 35.8 0.1 1.4e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS51823.2 - 2.7e-07 30.7 0.7 1.3e-06 28.6 0.0 2.5 3 0 0 3 3 3 1 Myb-like DNA-binding domain zf-UBR PF02207.20 AAS51823.2 - 0.0076 16.4 1.2 0.013 15.6 1.2 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-CCHC_2 PF13696.6 AAS51823.2 - 0.04 13.7 3.5 0.69 9.8 0.2 2.3 2 0 0 2 2 2 0 Zinc knuckle Elf1 PF05129.13 AAS51823.2 - 0.071 13.2 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF760 PF05542.11 AAS51823.2 - 0.08 13.3 0.1 0.23 11.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF760) KfrA_N PF11740.8 AAS51823.2 - 0.14 12.8 4.8 2.1 9.0 0.3 3.4 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Zip PF02535.22 AAS51824.1 - 2.4e-52 178.2 10.5 3e-50 171.3 10.5 2.0 1 1 0 1 1 1 1 ZIP Zinc transporter MFS_1 PF07690.16 AAS51825.2 - 2e-28 99.3 60.3 4.9e-27 94.8 30.8 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS51825.2 - 0.00067 18.6 17.5 0.00067 18.6 17.5 2.8 1 1 0 2 2 2 1 Sugar (and other) transporter AMPK1_CBM PF16561.5 AAS51826.1 - 3.9e-06 27.0 0.0 6.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase FAM104 PF15434.6 AAS51826.1 - 0.77 10.3 4.7 4.5 7.9 1.6 2.2 2 0 0 2 2 2 0 Family 104 STAG PF08514.11 AAS51827.2 - 3.3e-26 91.4 4.5 1.2e-25 89.6 0.5 3.7 4 0 0 4 4 4 1 STAG domain HEAT PF02985.22 AAS51827.2 - 0.00067 19.7 0.3 0.49 10.8 0.0 3.8 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.7 AAS51827.2 - 0.039 14.0 0.9 11 6.0 0.0 2.7 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Borrelia_orfA PF02414.15 AAS51827.2 - 0.15 11.7 0.0 0.15 11.7 0.0 2.9 3 0 0 3 3 3 0 Borrelia ORF-A MMgT PF10270.9 AAS51828.1 - 7.7e-24 84.0 0.1 1.3e-23 83.2 0.1 1.3 1 1 0 1 1 1 1 Membrane magnesium transporter ANAPC_CDC26 PF10471.9 AAS51829.1 - 4.2e-17 62.7 3.9 5.6e-17 62.3 3.9 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex APC subunit CDC26 RINGv PF12906.7 AAS51830.1 - 1.1e-14 54.2 6.8 2.2e-14 53.3 6.8 1.5 1 0 0 1 1 1 1 RING-variant domain Peptidase_C48 PF02902.19 AAS51831.2 - 6e-38 130.8 3.3 9.8e-38 130.2 3.3 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain DUF4441 PF14536.6 AAS51831.2 - 1.1 9.4 8.3 1.9 8.7 2.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) Cupin_8 PF13621.6 AAS51832.2 - 8.7e-06 25.6 0.0 0.011 15.4 0.0 2.3 2 0 0 2 2 2 2 Cupin-like domain PHD PF00628.29 AAS51832.2 - 0.00013 21.7 7.1 0.00027 20.8 7.1 1.5 1 0 0 1 1 1 1 PHD-finger JHD PF17811.1 AAS51832.2 - 0.0013 19.2 0.0 0.0023 18.4 0.0 1.4 1 0 0 1 1 1 1 Jumonji helical domain Cupin_1 PF00190.22 AAS51832.2 - 0.0064 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Cupin Cupin_4 PF08007.12 AAS51832.2 - 0.01 15.3 0.0 0.019 14.4 0.0 1.4 1 0 0 1 1 1 0 Cupin superfamily protein JmjC PF02373.22 AAS51832.2 - 0.014 15.8 0.0 9.6 6.7 0.0 2.9 3 0 0 3 3 3 0 JmjC domain, hydroxylase zf-HC5HC2H PF13771.6 AAS51832.2 - 0.02 15.1 2.6 0.045 14.0 2.6 1.6 1 0 0 1 1 1 0 PHD-like zinc-binding domain C1_1 PF00130.22 AAS51832.2 - 0.042 13.7 7.9 0.084 12.8 7.9 1.4 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cupin_2 PF07883.11 AAS51832.2 - 0.052 13.3 0.4 0.42 10.4 0.0 2.6 4 0 0 4 4 4 0 Cupin domain zf-HC5HC2H_2 PF13832.6 AAS51832.2 - 0.069 13.3 2.7 0.12 12.6 2.7 1.4 1 0 0 1 1 1 0 PHD-zinc-finger like domain NAD_binding_1 PF00175.21 AAS51833.1 - 1.5e-30 106.0 0.0 2.4e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AAS51833.1 - 6.5e-29 100.2 0.0 1e-28 99.6 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AAS51833.1 - 4.7e-05 23.6 0.0 0.0092 16.1 0.0 2.3 2 0 0 2 2 2 2 Ferric reductase NAD binding domain DUF2633 PF11119.8 AAS51833.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) AA_kinase PF00696.28 AAS51834.1 - 3.2e-41 141.5 0.2 8e-41 140.2 0.0 1.7 2 0 0 2 2 2 1 Amino acid kinase family ACT PF01842.25 AAS51834.1 - 5.6e-13 48.4 0.4 4.1e-05 23.3 0.0 3.0 2 0 0 2 2 2 2 ACT domain ACT_7 PF13840.6 AAS51834.1 - 7.6e-08 32.0 5.6 7.5e-06 25.7 0.5 3.2 3 0 0 3 3 3 2 ACT domain Desulfoferrodox PF01880.18 AAS51834.1 - 0.041 14.5 0.5 1.6 9.3 0.0 3.0 3 0 0 3 3 3 0 Desulfoferrodoxin Cyt-b5 PF00173.28 AAS51835.1 - 4.1e-20 71.7 0.0 6e-20 71.2 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF2269 PF10027.9 AAS51835.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) Use1 PF09753.9 AAS51835.1 - 0.14 11.9 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 ArfGap PF01412.18 AAS51836.1 - 8.2e-36 122.6 0.3 1.1e-35 122.3 0.3 1.2 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CBM_21 PF03370.13 AAS51837.2 - 9.6e-28 96.6 0.1 1.6e-27 95.9 0.1 1.3 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 AAS51837.2 - 4e-14 53.0 1.6 1e-13 51.7 1.6 1.8 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) WD40 PF00400.32 AAS51838.2 - 5.8e-34 115.6 31.3 3.3e-06 27.7 0.8 8.3 7 1 0 7 7 7 6 WD domain, G-beta repeat F-box-like PF12937.7 AAS51838.2 - 4.7e-15 55.2 0.4 9.3e-15 54.3 0.4 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS51838.2 - 1.8e-09 37.2 0.0 6.8e-09 35.4 0.0 2.0 1 1 1 2 2 2 1 F-box domain Nup160 PF11715.8 AAS51838.2 - 6.3e-09 35.0 13.2 0.013 14.1 0.1 5.8 3 2 2 6 6 6 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AAS51838.2 - 1.4e-05 25.3 1.3 1.5 9.1 0.0 5.0 2 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS51838.2 - 0.0034 16.8 0.2 1.6 8.0 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain F-box_4 PF15966.5 AAS51838.2 - 0.0047 16.8 0.0 0.016 15.1 0.0 1.9 1 0 0 1 1 1 1 F-box PALB2_WD40 PF16756.5 AAS51838.2 - 0.62 8.9 3.5 23 3.8 0.0 3.5 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain HisG PF01634.18 AAS51839.1 - 7.3e-51 172.3 0.0 9.7e-51 171.9 0.0 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 AAS51839.1 - 7.5e-26 90.1 0.0 1.3e-25 89.4 0.0 1.4 1 0 0 1 1 1 1 HisG, C-terminal domain NMT1 PF09084.11 AAS51839.1 - 0.02 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 NMT1/THI5 like EXS PF03124.14 AAS51840.2 - 1.3e-84 284.3 28.0 2e-84 283.7 28.0 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 AAS51840.2 - 6.3e-31 108.6 19.6 1.3e-20 74.7 1.7 3.1 2 1 1 3 3 3 2 SPX domain PhoLip_ATPase_C PF16212.5 AAS51841.1 - 1.1e-49 169.4 13.3 1.1e-49 169.4 13.3 2.3 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AAS51841.1 - 3.2e-18 65.2 1.8 3.2e-18 65.2 1.8 1.8 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 AAS51841.1 - 6e-12 45.5 0.0 6e-12 45.5 0.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AAS51841.1 - 1.7e-11 44.8 0.6 1.2e-05 25.8 1.2 3.0 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS51841.1 - 1.5e-10 41.1 0.0 5.1e-09 36.1 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 AAS51841.1 - 0.0075 16.0 0.0 0.023 14.4 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Prot_ATP_ID_OB PF16450.5 AAS51841.1 - 0.0097 15.8 0.0 0.028 14.3 0.0 1.8 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain Internalin_N PF12354.8 AAS51841.1 - 0.16 12.0 0.6 1.9 8.6 0.0 2.8 2 0 0 2 2 2 0 Bacterial adhesion/invasion protein N terminal CCDC85 PF10226.9 AAS51841.1 - 0.33 10.6 2.5 0.61 9.7 2.5 1.4 1 0 0 1 1 1 0 CCDC85 family DUF2070 PF09843.9 AAS51841.1 - 1.5 7.0 13.8 1.6 6.9 10.9 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Ribosomal_L34e PF01199.18 AAS51842.2 - 4e-42 142.4 4.4 4e-42 142.4 4.4 1.7 2 0 0 2 2 2 1 Ribosomal protein L34e Ribonuc_L-PSP PF01042.21 AAS51843.1 - 2.1e-39 134.2 0.2 2.6e-39 134.0 0.2 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP PET117 PF15786.5 AAS51844.1 - 7.8e-26 90.1 2.6 1.3e-25 89.4 2.6 1.4 1 1 0 1 1 1 1 PET assembly of cytochrome c oxidase, mitochondrial Cyclin PF08613.11 AAS51845.1 - 3.8e-46 157.4 0.7 5.6e-46 156.9 0.7 1.3 1 0 0 1 1 1 1 Cyclin Transp_cyt_pur PF02133.15 AAS51846.1 - 1.6e-70 238.1 40.2 1.9e-70 237.8 40.2 1.0 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Steroid_dh PF02544.16 AAS51847.1 - 6.1e-13 49.0 2.0 6.1e-13 49.0 2.0 2.0 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF4079 PF13301.6 AAS51847.1 - 2.5 8.3 7.0 5 7.3 0.0 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF4079) ketoacyl-synt PF00109.26 AAS51848.1 - 5.2e-55 186.8 0.1 5.2e-55 186.8 0.1 1.9 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AAS51848.1 - 2.5e-33 114.6 1.1 4.2e-33 113.9 1.1 1.4 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 AAS51848.1 - 0.0048 16.3 0.1 0.0098 15.3 0.1 1.5 1 0 0 1 1 1 1 Thiolase, N-terminal domain HAD_2 PF13419.6 AAS51849.1 - 1.7e-14 54.3 0.0 2.2e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AAS51849.1 - 7.4e-12 46.0 0.0 9.9e-10 39.1 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AAS51849.1 - 0.001 19.1 0.0 0.0022 18.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 AAS51849.1 - 0.031 14.7 0.0 0.04 14.3 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Tho1_MOS11_C PF18592.1 AAS51851.1 - 1.3e-24 85.7 1.0 2.5e-24 84.8 1.0 1.5 1 0 0 1 1 1 1 Tho1/MOS11 C-terminal domain SAP PF02037.27 AAS51851.1 - 6.3e-14 51.3 0.3 1.7e-13 50.0 0.1 1.8 2 0 0 2 2 2 1 SAP domain HeH PF12949.7 AAS51851.1 - 0.088 12.5 0.1 0.088 12.5 0.1 1.9 2 1 0 2 2 2 0 HeH/LEM domain Vhr1 PF04001.13 AAS51853.2 - 5.4e-46 154.8 1.2 1.2e-45 153.7 1.2 1.6 1 0 0 1 1 1 1 Transcription factor Vhr1 ICL PF00463.21 AAS51854.1 - 1.2e-275 915.0 0.0 1.3e-275 914.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 AAS51854.1 - 2.5e-09 36.9 0.0 5.1e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase RGI1 PF10843.8 AAS51855.2 - 2.6e-34 118.6 9.5 8.4e-34 116.9 9.5 1.7 1 1 0 1 1 1 1 Respiratory growth induced protein 1 zf-RING_4 PF14570.6 AAS51856.1 - 2.4e-20 72.0 13.4 4.6e-20 71.1 13.4 1.5 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain RRM_1 PF00076.22 AAS51856.1 - 3.5e-08 33.2 0.0 6.8e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3HC4_3 PF13920.6 AAS51856.1 - 5.8e-07 29.3 8.1 5.8e-07 29.3 8.1 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 AAS51856.1 - 6.5e-06 26.1 3.3 1.4e-05 25.0 3.3 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) SET_assoc PF11767.8 AAS51856.1 - 0.00014 21.4 0.2 0.0024 17.5 0.0 2.5 2 0 0 2 2 2 1 Histone lysine methyltransferase SET associated zf-RING_2 PF13639.6 AAS51856.1 - 0.00048 20.4 10.0 0.00048 20.4 10.0 1.7 2 0 0 2 2 1 1 Ring finger domain Rtf2 PF04641.12 AAS51856.1 - 0.00078 18.9 2.6 0.00078 18.9 2.6 2.2 2 0 0 2 2 2 1 Rtf2 RING-finger Prok-RING_4 PF14447.6 AAS51856.1 - 0.0032 17.3 8.6 0.11 12.3 9.3 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 AAS51856.1 - 0.006 16.4 11.0 0.013 15.4 11.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3H1 PF10650.9 AAS51856.1 - 0.17 11.6 2.5 0.19 11.5 0.1 2.3 2 0 0 2 2 2 0 Putative zinc-finger domain zf-RING_5 PF14634.6 AAS51856.1 - 0.17 11.9 9.8 0.36 10.8 9.8 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 AAS51856.1 - 0.33 11.0 10.0 0.9 9.6 10.0 1.8 1 0 0 1 1 1 0 RING-type zinc-finger PocR PF10114.9 AAS51856.1 - 1.2 8.9 5.9 0.31 10.8 2.0 1.9 2 0 0 2 2 2 0 Sensory domain found in PocR zf-C3HC4_2 PF13923.6 AAS51856.1 - 2 8.3 10.4 4.6 7.2 10.4 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Peptidase_S49_N PF08496.10 AAS51856.1 - 6 6.9 5.7 0.72 9.9 0.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal U1snRNP70_N PF12220.8 AAS51857.1 - 4.2e-23 81.8 1.5 7.3e-23 81.0 1.5 1.4 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RRM_1 PF00076.22 AAS51857.1 - 7.6e-16 57.7 0.0 1.8e-15 56.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS51857.1 - 0.0023 18.0 0.0 0.0047 17.0 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif PHM7_cyt PF14703.6 AAS51857.1 - 0.0082 16.4 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter NAT PF04768.13 AAS51858.2 - 4.1e-52 176.3 0.0 1.3e-51 174.6 0.0 1.9 3 0 0 3 3 3 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Semialdhyde_dh PF01118.24 AAS51858.2 - 8.5e-29 100.4 0.0 1.9e-28 99.3 0.0 1.6 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain AA_kinase PF00696.28 AAS51858.2 - 2.8e-26 92.6 0.0 4.8e-26 91.8 0.0 1.3 1 0 0 1 1 1 1 Amino acid kinase family DapB_N PF01113.20 AAS51858.2 - 0.006 16.7 0.0 0.016 15.3 0.0 1.7 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus P16-Arc PF04699.14 AAS51859.1 - 5.5e-44 150.2 0.0 6.2e-44 150.1 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Ran_BP1 PF00638.18 AAS51860.2 - 5.2e-29 101.0 0.0 9.8e-29 100.1 0.0 1.4 1 0 0 1 1 1 1 RanBP1 domain Methyltransf_31 PF13847.6 AAS51861.2 - 1.1e-23 83.7 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS51861.2 - 7e-13 49.0 0.1 1.1e-12 48.4 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS51861.2 - 1.1e-12 48.4 0.3 2.9e-12 47.1 0.3 1.7 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AAS51861.2 - 4.1e-09 36.2 0.0 1e-08 34.9 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AAS51861.2 - 8.6e-09 36.1 0.0 1.3e-08 35.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS51861.2 - 1.3e-08 34.8 0.0 2.5e-08 34.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AAS51861.2 - 4.1e-06 26.9 0.0 7.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AAS51861.2 - 3.8e-05 23.4 0.0 6.7e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TPMT PF05724.11 AAS51861.2 - 0.00015 21.5 0.0 0.00058 19.6 0.0 1.9 1 1 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) CMAS PF02353.20 AAS51861.2 - 0.0035 16.7 0.0 0.0046 16.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase AdoMet_MTase PF07757.13 AAS51861.2 - 0.0042 17.4 0.2 0.0068 16.7 0.1 1.4 1 1 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase PrmA PF06325.13 AAS51861.2 - 0.022 14.2 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Ubie_methyltran PF01209.18 AAS51861.2 - 0.03 13.7 0.0 0.061 12.7 0.0 1.6 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family PCMT PF01135.19 AAS51861.2 - 0.04 13.7 0.0 0.061 13.1 0.0 1.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.17 AAS51861.2 - 0.056 12.9 0.0 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_9 PF08003.11 AAS51861.2 - 0.11 11.5 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_18 PF12847.7 AAS51861.2 - 0.16 11.9 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TehB PF03848.14 AAS51861.2 - 0.2 11.0 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Fis1_TPR_C PF14853.6 AAS51862.1 - 2.2e-24 85.2 1.1 3.4e-24 84.7 1.1 1.3 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat Fis1_TPR_N PF14852.6 AAS51862.1 - 4.1e-17 61.5 0.0 7.4e-17 60.7 0.0 1.4 1 0 0 1 1 1 1 Fis1 N-terminal tetratricopeptide repeat TPR_2 PF07719.17 AAS51862.1 - 0.00011 22.0 1.2 0.00023 21.0 1.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS51862.1 - 0.00013 22.4 1.0 0.00037 21.0 1.0 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS51862.1 - 0.00051 20.6 0.7 0.00051 20.6 0.7 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AAS51862.1 - 0.016 15.7 0.0 0.023 15.2 0.0 1.4 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation ANAPC3 PF12895.7 AAS51862.1 - 0.036 14.3 0.7 0.062 13.5 0.6 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 AAS51862.1 - 0.066 13.9 0.3 0.21 12.3 0.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4287 PF14117.6 AAS51862.1 - 0.097 12.8 0.1 22 5.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4287) Ribonuc_red_lgC PF02867.15 AAS51863.2 - 1.9e-187 624.0 0.0 2.4e-187 623.6 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AAS51863.2 - 7.6e-25 86.7 0.1 4.3e-24 84.3 0.0 2.3 2 0 0 2 2 2 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AAS51863.2 - 4.7e-17 62.3 0.1 1.8e-16 60.5 0.0 2.2 2 0 0 2 2 2 1 ATP cone domain PUF PF00806.19 AAS51864.2 - 8.8e-56 182.6 33.8 2.7e-08 33.0 1.6 8.5 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat HECT PF00632.25 AAS51865.1 - 1.4e-94 317.0 0.0 1.9e-94 316.6 0.0 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) WW PF00397.26 AAS51865.1 - 7.6e-34 115.5 25.5 4.3e-12 45.9 3.3 4.0 4 0 0 4 4 4 3 WW domain C2 PF00168.30 AAS51865.1 - 5.6e-20 71.6 0.1 1.4e-19 70.3 0.1 1.7 1 0 0 1 1 1 1 C2 domain WD40 PF00400.32 AAS51866.1 - 4.9e-05 24.0 2.3 0.015 16.2 0.2 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 AAS51866.1 - 0.026 13.3 0.5 0.079 11.7 0.2 1.8 2 0 0 2 2 2 0 Nup133 N terminal like INCENP_N PF12178.8 AAS51866.1 - 0.055 13.5 0.1 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal Pkinase PF00069.25 AAS51867.1 - 2e-19 70.0 0.0 3e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51867.1 - 1.9e-10 40.5 0.0 2.6e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS51867.1 - 7.6e-06 24.9 1.3 2.7e-05 23.1 0.0 1.9 2 0 0 2 2 2 1 Fungal protein kinase Peptidase_M44 PF03410.13 AAS51867.1 - 0.039 12.5 0.0 0.066 11.8 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox MRG PF05712.13 AAS51868.1 - 1.9e-40 138.3 0.0 3.3e-40 137.5 0.0 1.3 1 0 0 1 1 1 1 MRG Tudor-knot PF11717.8 AAS51868.1 - 1.2e-06 28.3 0.2 2.3e-06 27.4 0.2 1.5 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-C2H2 PF00096.26 AAS51869.1 - 1e-10 41.4 11.1 4.7e-05 23.6 1.6 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS51869.1 - 4.6e-08 33.2 8.3 0.001 19.7 0.9 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS51869.1 - 3.5e-06 27.2 14.2 1.4e-05 25.3 1.4 3.3 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 AAS51869.1 - 2.6e-05 24.4 5.1 0.00067 20.0 0.5 2.5 2 0 0 2 2 2 2 Zinc-finger of C2H2 type C1_4 PF07975.12 AAS51869.1 - 0.0037 17.5 2.9 0.0064 16.7 2.9 1.4 1 0 0 1 1 1 1 TFIIH C1-like domain zf-C2H2_jaz PF12171.8 AAS51869.1 - 0.0059 16.9 1.2 0.19 12.0 0.1 2.4 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AAS51869.1 - 0.033 14.2 3.9 0.25 11.4 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS51870.1 - 1.4e-10 41.0 7.0 2.2e-05 24.6 0.7 2.4 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS51870.1 - 3.7e-08 33.5 4.9 0.0035 18.1 0.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AAS51870.1 - 2e-05 24.8 5.5 0.0069 16.7 0.2 2.9 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AAS51870.1 - 3.6e-05 24.0 11.5 0.23 12.0 0.0 3.4 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 AAS51870.1 - 5.9e-05 23.0 4.5 0.007 16.3 0.2 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_5 PF13909.6 AAS51870.1 - 0.019 14.7 0.9 0.019 14.7 0.9 2.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 AAS51870.1 - 0.021 14.5 2.5 2.7 7.8 0.3 2.3 2 0 0 2 2 2 0 zinc-finger C2H2-type DUF2256 PF10013.9 AAS51870.1 - 0.029 14.5 0.6 0.067 13.3 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) Rad50_zn_hook PF04423.14 AAS51870.1 - 0.11 12.4 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-Di19 PF05605.12 AAS51870.1 - 0.14 12.5 2.1 0.42 10.9 2.1 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 AAS51870.1 - 0.24 11.7 1.8 14 6.1 0.0 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Mito_carr PF00153.27 AAS51871.1 - 8.4e-72 237.2 0.0 1.5e-24 85.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AAS51871.1 - 0.1 11.8 0.1 12 4.9 0.0 3.2 3 1 1 4 4 4 0 Gammaproteobacterial serine protease EF-hand_8 PF13833.6 AAS51871.1 - 0.15 11.9 0.2 3.8 7.4 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain pair SAE2 PF08573.10 AAS51872.1 - 3.5 8.8 0.0 3.5 8.8 0.0 3.4 4 1 0 4 4 4 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Bud13 PF09736.9 AAS51873.1 - 7.9e-23 81.5 5.8 1.2e-21 77.6 1.0 3.3 1 1 2 3 3 3 2 Pre-mRNA-splicing factor of RES complex AAA_28 PF13521.6 AAS51873.1 - 0.0081 16.4 0.5 0.013 15.8 0.5 1.4 1 0 0 1 1 1 1 AAA domain XRN_N PF03159.18 AAS51874.1 - 7e-92 307.2 0.1 7e-92 307.2 0.1 2.0 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 AAS51874.1 - 2.7e-88 296.9 8.7 2.7e-88 296.9 8.7 2.5 2 1 1 3 3 3 1 Xrn1 helical domain XRN1_D1 PF18332.1 AAS51874.1 - 2.4e-62 210.1 0.8 5.7e-62 208.9 0.0 2.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 AAS51874.1 - 4e-33 113.5 0.0 1.2e-32 112.0 0.0 1.9 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D2/D3 domain SH3_12 PF18129.1 AAS51874.1 - 8e-19 67.5 0.2 2e-18 66.3 0.2 1.7 1 0 0 1 1 1 1 Xrn1 SH3-like domain Xrn1_D3 PF18194.1 AAS51874.1 - 1e-18 67.2 1.1 3.9e-18 65.3 0.2 2.5 2 0 0 2 2 2 1 Exoribonuclease 1 Domain-3 Nucleoporin_FG PF13634.6 AAS51875.1 - 2.1e-08 34.9 67.7 5.2e-05 24.0 23.5 3.2 2 1 1 3 3 3 2 Nucleoporin FG repeat region Apolipoprotein PF01442.18 AAS51875.1 - 0.013 15.4 1.0 0.039 13.8 0.0 2.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1664 PF07889.12 AAS51875.1 - 0.038 14.0 2.9 1.7 8.7 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) KxDL PF10241.9 AAS51875.1 - 0.45 10.8 5.1 18 5.7 1.6 3.0 3 1 0 3 3 3 0 Uncharacterized conserved protein Pkinase PF00069.25 AAS51877.1 - 5.9e-43 147.1 0.0 3.3e-42 144.7 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51877.1 - 9.7e-19 67.7 0.0 2.7e-18 66.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS51877.1 - 0.0045 15.8 0.0 0.006 15.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AAS51877.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family zf-C2H2 PF00096.26 AAS51878.1 - 3.1e-09 36.8 15.4 8.5e-06 25.9 0.1 3.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS51878.1 - 5.5e-08 33.0 10.6 0.00035 21.2 0.2 2.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS51878.1 - 5.4e-06 26.6 12.8 0.0024 18.2 1.0 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 AAS51878.1 - 0.00011 22.4 1.8 0.014 15.7 0.0 2.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AAS51878.1 - 0.00091 19.4 2.2 0.022 15.1 0.0 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 AAS51878.1 - 0.0034 17.4 3.2 0.025 14.6 0.1 2.7 1 1 1 2 2 2 1 BED zinc finger zf-C2H2_6 PF13912.6 AAS51878.1 - 0.031 14.3 2.0 0.17 11.9 0.0 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 AAS51878.1 - 0.37 11.1 4.2 1.3 9.3 0.2 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 AAS51878.1 - 9 6.2 14.3 0.45 10.3 2.7 2.9 3 0 0 3 3 3 0 C2H2-type zinc-finger domain CHCH PF06747.13 AAS51879.2 - 0.006 16.7 2.0 1 9.6 0.6 2.1 2 0 0 2 2 2 2 CHCH domain CX9C PF16860.5 AAS51879.2 - 0.011 15.7 1.2 0.018 15.0 1.2 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Cmc1 PF08583.10 AAS51879.2 - 0.031 14.3 0.5 0.037 14.1 0.5 1.1 1 0 0 1 1 1 0 Cytochrome c oxidase biogenesis protein Cmc1 like zf-C2H2 PF00096.26 AAS51880.2 - 3.1e-08 33.6 10.0 0.001 19.4 2.7 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS51880.2 - 4.4e-05 24.0 8.9 0.082 13.8 1.7 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS51880.2 - 0.00027 21.2 0.2 0.00027 21.2 0.2 2.9 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 AAS51880.2 - 0.0047 17.3 6.4 0.084 13.3 0.3 2.7 2 0 0 2 2 2 2 Zinc-finger of C2H2 type FOXP-CC PF16159.5 AAS51880.2 - 0.0071 17.0 0.2 0.014 16.0 0.2 1.4 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-H2C2_5 PF13909.6 AAS51880.2 - 0.058 13.2 6.1 0.25 11.2 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.8 AAS51880.2 - 0.16 12.3 3.1 9.3 6.7 0.0 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AAS51880.2 - 2.5 8.5 6.2 2.9 8.3 0.5 2.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) tRNA-synt_2 PF00152.20 AAS51881.1 - 4.7e-82 275.6 1.3 7e-82 275.0 1.3 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS51881.1 - 2.4e-06 27.4 0.1 5.7e-06 26.2 0.1 1.7 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RasGEF PF00617.19 AAS51882.2 - 3.3e-56 190.3 0.1 3.3e-56 190.3 0.1 2.3 3 0 0 3 3 3 1 RasGEF domain RasGEF_N PF00618.20 AAS51882.2 - 1.3e-23 83.3 0.1 4.3e-23 81.6 0.1 2.0 1 0 0 1 1 1 1 RasGEF N-terminal motif SH3_9 PF14604.6 AAS51882.2 - 2e-09 37.2 0.0 3.9e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AAS51882.2 - 6e-08 32.2 0.0 2.6e-07 30.1 0.0 2.2 1 1 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS51882.2 - 1.4e-07 31.1 0.1 4.6e-07 29.4 0.0 1.9 2 0 0 2 2 2 1 Variant SH3 domain GRIP PF01465.20 AAS51883.2 - 6.1e-14 51.6 0.5 6.1e-13 48.4 0.3 2.6 2 0 0 2 2 2 1 GRIP domain TPR_MLP1_2 PF07926.12 AAS51883.2 - 1.2e-06 28.6 138.9 0.00046 20.2 14.3 7.8 4 1 2 7 7 7 4 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 AAS51883.2 - 0.00018 20.5 123.9 0.052 12.4 19.8 6.2 2 1 4 6 6 6 5 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 AAS51883.2 - 0.00064 19.8 19.1 0.00064 19.8 19.1 7.8 3 3 4 7 7 7 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SHE3 PF17078.5 AAS51883.2 - 0.0043 16.8 13.0 0.0043 16.8 13.0 7.7 3 2 4 8 8 8 2 SWI5-dependent HO expression protein 3 PKcGMP_CC PF16808.5 AAS51883.2 - 0.005 16.7 3.2 0.005 16.7 3.2 7.5 7 2 1 8 8 8 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Golgin_A5 PF09787.9 AAS51883.2 - 1.7 8.1 124.3 0.04 13.4 18.2 5.3 2 1 3 5 5 5 0 Golgin subfamily A member 5 Tnp_22_trimer PF17489.2 AAS51883.2 - 3.8 7.6 15.5 26 4.9 0.7 5.2 4 1 1 5 5 5 0 L1 transposable element trimerization domain AAA_13 PF13166.6 AAS51883.2 - 4.1 5.9 94.8 0.38 9.3 22.6 4.3 2 1 2 4 4 4 0 AAA domain DUF1664 PF07889.12 AAS51883.2 - 5.9 7.0 73.0 0.018 15.1 4.0 8.2 3 3 5 8 8 8 0 Protein of unknown function (DUF1664) Polysacc_deac_1 PF01522.21 AAS51884.1 - 2.3e-24 85.6 0.0 3.7e-24 85.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 AAS51884.1 - 0.015 14.5 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Cys_rich_VLP PF14194.6 AAS51884.1 - 0.075 13.2 0.8 0.16 12.1 0.8 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP UQ_con PF00179.26 AAS51886.1 - 3e-33 114.4 0.0 3.9e-33 114.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS51886.1 - 0.071 12.8 0.1 0.11 12.2 0.1 1.5 1 1 0 1 1 1 0 Prokaryotic E2 family B PI3_PI4_kinase PF00454.27 AAS51888.1 - 1.7e-41 142.7 0.0 4.5e-39 134.8 0.0 2.8 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 AAS51888.1 - 7.2e-26 90.7 0.2 1.9e-25 89.3 0.2 1.7 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Phage_TAC_3 PF06896.11 AAS51888.1 - 0.0089 16.6 0.3 0.028 15.0 0.3 1.8 1 0 0 1 1 1 1 Phage tail assembly chaperone proteins, TAC FANCI_S3 PF14677.6 AAS51888.1 - 3.1 7.5 8.8 0.38 10.4 1.0 3.3 3 0 0 3 3 3 0 FANCI solenoid 3 Aconitase PF00330.20 AAS51889.1 - 7.5e-149 496.6 0.0 9.3e-149 496.3 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AAS51889.1 - 2.5e-46 157.2 0.0 4.8e-46 156.3 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain Como_SCP PF02248.16 AAS51889.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Small coat protein Cys_Met_Meta_PP PF01053.20 AAS51890.2 - 5.6e-141 469.5 0.0 6.4e-141 469.3 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 AAS51890.2 - 2.7e-09 36.7 0.0 4.4e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AAS51890.2 - 2.1e-07 30.3 0.1 3e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AAS51890.2 - 3.9e-06 26.4 0.1 9e-06 25.2 0.1 1.5 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Met_gamma_lyase PF06838.11 AAS51890.2 - 3.4e-05 22.5 0.0 5.6e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Methionine gamma-lyase Beta_elim_lyase PF01212.21 AAS51890.2 - 0.00051 19.4 0.0 0.0019 17.6 0.0 1.9 1 1 0 1 1 1 1 Beta-eliminating lyase Asparaginase_C PF17763.1 AAS51890.2 - 0.043 14.0 0.0 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Glutaminase/Asparaginase C-terminal domain GDC-P PF02347.16 AAS51890.2 - 0.077 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Glycine cleavage system P-protein eIF-6 PF01912.18 AAS51891.1 - 6e-82 273.8 0.9 7.5e-82 273.5 0.9 1.1 1 0 0 1 1 1 1 eIF-6 family Csm1_N PF18504.1 AAS51892.1 - 0.48 10.8 3.1 0.51 10.7 1.4 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain CAF1A PF12253.8 AAS51893.2 - 1.8e-22 79.2 10.9 1.8e-22 79.2 10.9 4.4 3 1 0 3 3 3 1 Chromatin assembly factor 1 subunit A TFIIA PF03153.13 AAS51893.2 - 0.00087 19.4 23.7 0.00087 19.4 23.7 1.6 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Rhabdo_ncap PF00945.18 AAS51893.2 - 0.65 8.8 6.0 1.7 7.4 6.0 1.6 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Exonuc_VII_L PF02601.15 AAS51893.2 - 1.1 8.8 16.0 1.7 8.2 16.0 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Borrelia_P83 PF05262.11 AAS51893.2 - 2.2 6.7 35.5 3.2 6.1 35.5 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein FapA PF03961.13 AAS51893.2 - 5.3 5.5 25.1 11 4.5 25.1 1.5 1 0 0 1 1 1 0 Flagellar Assembly Protein A EI24 PF07264.11 AAS51894.1 - 4.8e-06 26.9 15.2 6.4e-06 26.5 15.2 1.2 1 0 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) RICTOR_V PF14668.6 AAS51894.1 - 0.015 15.5 1.2 0.079 13.2 0.1 2.3 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 MCM PF00493.23 AAS51895.2 - 3.7e-101 336.9 0.0 5.6e-101 336.3 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AAS51895.2 - 1.4e-37 128.4 1.1 2.7e-37 127.4 0.3 1.9 2 0 0 2 2 2 1 MCM OB domain MCM_lid PF17855.1 AAS51895.2 - 4.6e-29 100.7 2.2 1.2e-28 99.4 2.2 1.8 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AAS51895.2 - 1.4e-19 70.6 1.1 7.3e-19 68.3 1.1 2.3 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 AAS51895.2 - 7.8e-06 25.9 0.0 3.1e-05 24.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AAS51895.2 - 8e-06 25.4 0.0 0.00036 20.0 0.0 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AAS51895.2 - 0.00065 19.6 0.0 0.0078 16.1 0.0 2.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS51895.2 - 0.006 17.0 0.9 1.4 9.3 0.1 3.2 3 1 0 3 3 3 1 AAA ATPase domain Sigma54_activat PF00158.26 AAS51895.2 - 0.11 12.2 0.2 2.9 7.6 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain ATP-synt_G PF04718.15 AAS51896.1 - 1.7e-28 99.4 0.1 2e-28 99.1 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit DEAD PF00270.29 AAS51897.1 - 3.2e-43 147.5 1.6 6.1e-43 146.6 0.1 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS51897.1 - 9e-32 109.7 5.8 3.6e-29 101.3 0.1 2.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51897.1 - 8.6e-08 32.4 0.6 2.7e-07 30.7 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS51897.1 - 0.1 12.9 0.3 0.82 9.9 0.3 2.4 1 1 0 1 1 1 0 AAA domain Ribonucleas_3_3 PF14622.6 AAS51898.1 - 1.2e-15 57.8 0.0 1.8e-15 57.2 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like GIT_SHD PF08518.11 AAS51899.2 - 2e-24 84.9 8.1 7.2e-12 44.7 0.5 3.2 3 0 0 3 3 3 2 Spa2 homology domain (SHD) of GIT GIT1_C PF12205.8 AAS51899.2 - 0.00054 20.1 0.1 0.00054 20.1 0.1 2.6 2 1 0 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term Wtap PF17098.5 AAS51899.2 - 0.00085 19.3 1.5 0.00085 19.3 1.5 3.0 2 1 0 2 2 2 1 WTAP/Mum2p family CSN5_C PF18323.1 AAS51899.2 - 0.079 13.9 3.9 2.3 9.2 3.9 3.8 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain HOOK PF05622.12 AAS51899.2 - 1.8 6.6 28.2 5.2 5.1 14.5 2.8 1 1 2 3 3 3 0 HOOK protein LMBR1 PF04791.16 AAS51899.2 - 4.1 6.2 7.9 7.6 5.3 7.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Glyco_hydro_72 PF03198.14 AAS51900.2 - 4.8e-137 456.4 4.5 5.9e-137 456.1 4.5 1.0 1 0 0 1 1 1 1 Glucanosyltransferase Cellulase PF00150.18 AAS51900.2 - 0.0028 17.1 0.7 0.015 14.7 0.4 2.0 2 0 0 2 2 2 1 Cellulase (glycosyl hydrolase family 5) FSA_C PF10479.9 AAS51900.2 - 6.9 4.7 6.1 2.3 6.3 0.0 2.0 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus WSC PF01822.19 AAS51901.2 - 1.6e-08 34.6 8.3 3.4e-08 33.5 8.3 1.6 1 0 0 1 1 1 1 WSC domain Podoplanin PF05808.11 AAS51901.2 - 1.8e-05 24.9 3.6 3.3e-05 24.1 3.6 1.4 1 0 0 1 1 1 1 Podoplanin Glycophorin_A PF01102.18 AAS51901.2 - 0.00067 19.9 0.8 0.0014 18.8 0.1 1.9 1 1 1 2 2 2 1 Glycophorin A DUF5305 PF17231.2 AAS51901.2 - 0.00093 18.7 0.1 0.0014 18.1 0.1 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5305) Syndecan PF01034.20 AAS51901.2 - 0.0074 16.2 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Syndecan domain Mid2 PF04478.12 AAS51901.2 - 0.041 13.7 0.1 0.083 12.7 0.1 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Adeno_E3_CR2 PF02439.15 AAS51901.2 - 0.062 13.1 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Amnionless PF14828.6 AAS51901.2 - 0.066 12.0 0.0 0.066 12.0 0.0 1.7 2 0 0 2 2 2 0 Amnionless Rick_17kDa_Anti PF05433.15 AAS51901.2 - 0.08 12.8 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 Glycine zipper 2TM domain DUF2207 PF09972.9 AAS51901.2 - 0.14 10.8 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Holin_BhlA PF10960.8 AAS51901.2 - 0.21 11.6 0.2 0.39 10.7 0.2 1.3 1 0 0 1 1 1 0 BhlA holin family DUF2408 PF10303.9 AAS51902.2 - 5.3e-58 195.4 5.7 1.1e-40 139.4 0.0 5.0 2 2 2 4 4 4 3 Protein of unknown function (DUF2408) TnpV PF14198.6 AAS51902.2 - 0.057 13.4 1.0 0.66 10.0 0.3 2.8 3 0 0 3 3 3 0 Transposon-encoded protein TnpV DED PF01335.21 AAS51902.2 - 0.059 13.7 0.9 0.27 11.6 0.0 2.6 3 0 0 3 3 3 0 Death effector domain DUF2096 PF09869.9 AAS51902.2 - 0.062 13.4 0.2 0.9 9.6 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) AhpC-TSA PF00578.21 AAS51903.1 - 1.1e-30 106.0 0.0 1.7e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AAS51903.1 - 3.1e-19 69.1 0.0 4.7e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 AAS51903.1 - 0.00022 21.3 0.0 0.00045 20.3 0.0 1.5 1 0 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF1644 PF07800.12 AAS51903.1 - 0.023 14.8 0.0 0.044 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1644) Adap_comp_sub PF00928.21 AAS51904.1 - 1.8e-91 306.2 0.1 2.3e-91 305.8 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AAS51904.1 - 4.4e-07 29.9 2.3 8.5e-07 29.0 1.8 1.7 1 1 1 2 2 2 1 Clathrin adaptor complex small chain muHD PF10291.9 AAS51904.1 - 0.0062 16.0 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain TPP1 PF10341.9 AAS51905.1 - 6.2e-25 87.3 0.0 9.3e-25 86.8 0.0 1.3 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD HTH_ABP1_N PF18107.1 AAS51905.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain HMGL-like PF00682.19 AAS51906.1 - 2.2e-78 263.5 0.0 2.9e-78 263.1 0.0 1.2 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.10 AAS51906.1 - 2.4e-24 85.7 0.0 1e-23 83.7 0.0 2.1 3 0 0 3 3 3 1 LeuA allosteric (dimerisation) domain Urm1 PF09138.11 AAS51907.1 - 1.2e-37 128.2 0.6 1.3e-37 128.0 0.6 1.0 1 0 0 1 1 1 1 Urm1 (Ubiquitin related modifier) ThiS PF02597.20 AAS51907.1 - 0.0051 17.4 0.0 0.0062 17.1 0.0 1.2 1 0 0 1 1 1 1 ThiS family YchF-GTPase_C PF06071.13 AAS51907.1 - 0.075 13.2 0.2 0.39 10.9 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF933) Nas2_N PF18265.1 AAS51908.1 - 3.5e-22 78.1 0.1 5.4e-22 77.5 0.1 1.3 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 AAS51908.1 - 3.9e-06 26.6 0.2 1e-05 25.3 0.2 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 AAS51908.1 - 6e-06 26.5 0.1 1.2e-05 25.5 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 AAS51908.1 - 1.5e-05 25.2 0.1 2.3e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 PDZ domain Ribosomal_L12_N PF16320.5 AAS51908.1 - 0.012 15.3 0.4 0.031 14.0 0.4 1.7 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain FAA_hydrolase_N PF09298.11 AAS51908.1 - 0.016 15.4 0.1 0.12 12.6 0.0 2.2 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal bZIP_2 PF07716.15 AAS51909.2 - 2.4e-11 43.6 11.6 4.7e-11 42.6 11.6 1.5 1 0 0 1 1 1 1 Basic region leucine zipper bZIP_1 PF00170.21 AAS51909.2 - 2.5e-10 40.3 8.0 5.1e-10 39.3 8.0 1.4 1 0 0 1 1 1 1 bZIP transcription factor bZIP_Maf PF03131.17 AAS51909.2 - 0.0019 18.7 3.2 0.0038 17.7 3.2 1.4 1 0 0 1 1 1 1 bZIP Maf transcription factor ZapB PF06005.12 AAS51909.2 - 0.0075 16.7 1.7 0.016 15.7 1.7 1.5 1 0 0 1 1 1 1 Cell division protein ZapB YabA PF06156.13 AAS51909.2 - 0.02 15.5 0.8 0.04 14.6 0.8 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Mis14 PF08641.12 AAS51909.2 - 0.025 14.9 1.6 0.049 13.9 1.6 1.5 1 0 0 1 1 1 0 Kinetochore protein Mis14 like DivIC PF04977.15 AAS51909.2 - 0.04 13.7 1.5 0.069 12.9 1.5 1.4 1 0 0 1 1 1 0 Septum formation initiator FAM76 PF16046.5 AAS51909.2 - 0.068 12.5 0.5 0.12 11.7 0.5 1.4 1 0 0 1 1 1 0 FAM76 protein GIT_CC PF16559.5 AAS51909.2 - 0.076 12.9 0.8 0.3 11.0 0.8 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 AAS51909.2 - 0.095 13.0 1.3 0.18 12.2 1.3 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family LCE6A PF15858.5 AAS51909.2 - 1.3 9.9 6.0 8.5 7.2 1.4 2.5 2 0 0 2 2 2 0 Late cornified envelope protein 6A family FixP_N PF14715.6 AAS51910.2 - 0.11 12.2 0.3 0.18 11.5 0.3 1.3 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Gti1_Pac2 PF09729.9 AAS51911.1 - 9.3e-53 179.0 0.3 1.2e-42 146.0 0.0 3.5 2 2 1 3 3 3 2 Gti1/Pac2 family Mito_carr PF00153.27 AAS51912.1 - 7.4e-69 227.8 1.4 1e-25 89.5 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AAS51912.1 - 0.031 13.4 0.3 5.1 6.2 0.0 3.0 3 0 0 3 3 3 0 Gammaproteobacterial serine protease Thioredoxin PF00085.20 AAS51913.1 - 1e-17 64.0 0.1 1.2e-16 60.6 0.0 2.8 4 0 0 4 4 4 1 Thioredoxin OST3_OST6 PF04756.13 AAS51913.1 - 0.00017 21.1 0.7 0.046 13.1 0.0 2.8 2 1 1 3 3 3 2 OST3 / OST6 family, transporter family LDB19 PF13002.7 AAS51913.1 - 0.013 15.2 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Arrestin_N terminal like Use1 PF09753.9 AAS51914.1 - 0.00029 20.6 0.1 0.00037 20.3 0.1 1.4 1 1 0 1 1 1 1 Membrane fusion protein Use1 Synaptobrevin PF00957.21 AAS51914.1 - 0.0038 17.0 0.9 0.0064 16.3 0.9 1.4 1 1 0 1 1 1 1 Synaptobrevin Sec20 PF03908.13 AAS51914.1 - 0.01 15.8 1.2 0.037 13.9 0.1 1.9 1 1 1 2 2 2 1 Sec20 DUF2207 PF09972.9 AAS51914.1 - 0.03 13.1 0.1 0.031 13.1 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) ATXN-1_C PF12547.8 AAS51914.1 - 0.036 14.4 0.4 0.07 13.5 0.4 1.5 1 0 0 1 1 1 0 Capicua transcriptional repressor modulator DUF16 PF01519.16 AAS51914.1 - 0.11 13.0 0.0 0.15 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 ParA PF10609.9 AAS51915.1 - 6.9e-95 317.2 0.0 1e-94 316.6 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AAS51915.1 - 6.1e-11 42.5 0.0 5.2e-10 39.5 0.0 2.2 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AAS51915.1 - 2.6e-07 30.7 0.7 7.3e-05 22.7 0.1 2.7 3 0 0 3 3 3 1 AAA domain MipZ PF09140.11 AAS51915.1 - 5.3e-06 25.9 0.1 2.3e-05 23.8 0.1 1.9 1 1 0 1 1 1 1 ATPase MipZ MeaB PF03308.16 AAS51915.1 - 0.00016 20.7 2.3 0.00019 20.5 0.6 1.7 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ArsA_ATPase PF02374.15 AAS51915.1 - 0.00046 19.5 1.2 0.0011 18.2 0.9 1.7 2 0 0 2 2 2 1 Anion-transporting ATPase AAA_26 PF13500.6 AAS51915.1 - 0.0038 17.1 0.0 0.72 9.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 AAS51915.1 - 0.0077 15.8 0.0 0.014 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain CBP_BcsQ PF06564.12 AAS51915.1 - 0.021 14.3 0.3 0.045 13.2 0.3 1.7 1 1 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Fer4_NifH PF00142.18 AAS51915.1 - 0.045 13.2 0.2 0.099 12.1 0.2 1.6 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family IstB_IS21 PF01695.17 AAS51915.1 - 0.061 13.0 0.0 0.2 11.4 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein APS_kinase PF01583.20 AAS51915.1 - 0.066 13.1 0.1 0.11 12.4 0.1 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase RsgA_GTPase PF03193.16 AAS51915.1 - 0.13 12.1 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase Golgin_A5 PF09787.9 AAS51916.1 - 0.0074 15.8 2.2 0.0074 15.8 2.2 1.4 2 0 0 2 2 2 1 Golgin subfamily A member 5 P4Ha_N PF08336.11 AAS51916.1 - 0.021 14.8 0.3 0.041 13.9 0.3 1.5 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF4763 PF15960.5 AAS51916.1 - 0.022 14.1 1.5 0.032 13.5 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) TMPIT PF07851.13 AAS51916.1 - 0.028 13.7 1.8 0.038 13.2 1.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein AAA_13 PF13166.6 AAS51916.1 - 0.028 13.1 1.0 0.045 12.4 1.0 1.2 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 AAS51916.1 - 0.029 13.7 1.8 0.044 13.1 1.8 1.3 1 0 0 1 1 1 0 FAM76 protein DUF892 PF05974.12 AAS51916.1 - 0.038 14.0 0.6 0.078 13.0 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF892) CLZ PF16526.5 AAS51916.1 - 0.076 13.4 1.1 14 6.1 2.2 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels COG5 PF10392.9 AAS51916.1 - 0.08 13.1 3.1 0.16 12.1 3.1 1.5 1 1 0 1 1 1 0 Golgi transport complex subunit 5 Fib_alpha PF08702.10 AAS51916.1 - 0.16 12.2 2.3 0.29 11.3 2.3 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 AAS51916.1 - 0.17 11.9 5.7 0.5 10.4 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 AAS51916.1 - 0.18 10.7 4.5 0.26 10.1 4.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Prominin PF05478.11 AAS51916.1 - 0.19 9.6 1.1 0.25 9.2 1.1 1.1 1 0 0 1 1 1 0 Prominin NPV_P10 PF05531.12 AAS51916.1 - 0.72 10.4 5.0 5.5 7.5 5.0 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SKA1 PF07160.12 AAS51916.1 - 0.81 9.5 8.4 1.4 8.7 5.6 2.3 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 1 Prefoldin_2 PF01920.20 AAS51917.2 - 5.5e-24 84.2 7.4 6.1e-24 84.0 7.4 1.0 1 0 0 1 1 1 1 Prefoldin subunit Prefoldin PF02996.17 AAS51917.2 - 0.0021 17.9 3.8 0.029 14.3 3.8 2.0 1 1 0 1 1 1 1 Prefoldin subunit FapA PF03961.13 AAS51917.2 - 0.0099 14.5 5.1 0.016 13.8 5.1 1.3 1 1 0 1 1 1 1 Flagellar Assembly Protein A ZapB PF06005.12 AAS51917.2 - 0.031 14.7 6.4 1.8 9.1 1.5 2.2 2 0 0 2 2 2 0 Cell division protein ZapB DUF2383 PF09537.10 AAS51917.2 - 0.032 14.6 0.1 0.11 12.9 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2383) IL31 PF15209.6 AAS51917.2 - 0.051 13.4 2.1 0.74 9.6 0.1 2.1 2 0 0 2 2 2 0 Interleukin 31 Spc24 PF08286.11 AAS51917.2 - 0.18 12.0 6.1 0.81 10.0 1.0 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 SAS4 PF15460.6 AAS51917.2 - 0.3 11.2 4.1 2.3 8.4 4.1 2.1 1 1 0 1 1 1 0 Something about silencing, SAS, complex subunit 4 DDOST_48kD PF03345.14 AAS51918.2 - 1.2e-120 403.2 0.8 1.4e-120 402.9 0.8 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase 48 kDa subunit beta Syja_N PF02383.18 AAS51919.1 - 3.7e-46 157.9 0.1 6.4e-46 157.1 0.1 1.3 1 0 0 1 1 1 1 SacI homology domain Exo_endo_phos PF03372.23 AAS51919.1 - 1.1e-08 34.9 0.0 1.6e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Wzt_C PF14524.6 AAS51920.1 - 0.018 15.1 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Wzt C-terminal domain CagX PF03524.15 AAS51920.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Conjugal transfer protein RRM_1 PF00076.22 AAS51921.1 - 1.2e-17 63.4 0.0 2e-17 62.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 AAS51921.1 - 0.0031 17.4 0.1 0.0056 16.6 0.1 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 AAS51921.1 - 0.0037 17.2 0.0 0.0064 16.5 0.0 1.4 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nop16 PF09420.10 AAS51922.1 - 1.8e-69 234.0 10.1 2.8e-69 233.4 10.1 1.3 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 PMI_typeI PF01238.21 AAS51923.1 - 7.1e-148 492.8 0.0 8.1e-148 492.6 0.0 1.0 1 0 0 1 1 1 1 Phosphomannose isomerase type I AraC_binding PF02311.19 AAS51923.1 - 0.00017 21.5 0.1 0.019 14.9 0.0 2.7 2 0 0 2 2 2 1 AraC-like ligand binding domain Cupin_2 PF07883.11 AAS51923.1 - 0.074 12.8 0.0 1.7 8.4 0.0 2.4 2 0 0 2 2 2 0 Cupin domain Hexapep PF00132.24 AAS51924.2 - 6e-06 25.8 11.0 0.0028 17.3 2.2 4.8 3 1 2 5 5 5 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AAS51924.2 - 0.3 10.9 14.0 0.61 9.9 5.2 3.3 3 1 0 3 3 3 0 Hexapeptide repeat of succinyl-transferase HIM1 PF08732.10 AAS51925.1 - 3.9e-08 33.0 0.0 9.5e-08 31.7 0.0 1.5 1 1 0 1 1 1 1 HIM1 NAD_binding_10 PF13460.6 AAS51925.1 - 3e-07 30.5 1.2 4.4e-07 30.0 0.2 1.8 2 1 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 AAS51925.1 - 0.002 17.6 0.1 0.0052 16.3 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 AAS51925.1 - 0.0039 16.8 0.3 0.0072 15.9 0.2 1.6 2 1 0 2 2 2 1 NmrA-like family Semialdhyde_dh PF01118.24 AAS51925.1 - 0.0064 16.9 0.1 0.024 15.1 0.0 1.8 1 1 1 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_4 PF07993.12 AAS51925.1 - 0.012 14.8 0.0 0.1 11.7 0.0 2.5 2 1 0 2 2 2 0 Male sterility protein GDA1_CD39 PF01150.17 AAS51926.2 - 3.4e-124 414.8 0.2 5.9e-124 414.0 0.0 1.3 2 0 0 2 2 2 1 GDA1/CD39 (nucleoside phosphatase) family TFIIB PF00382.19 AAS51927.2 - 4.8e-50 167.5 2.2 3.6e-26 91.0 0.7 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AAS51927.2 - 4.1e-13 48.6 0.8 7e-13 47.9 0.8 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AAS51927.2 - 0.032 13.6 1.0 1.5 8.3 0.0 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Poxvirus PF06227.12 AAS51927.2 - 0.04 13.7 0.2 0.058 13.2 0.2 1.3 1 0 0 1 1 1 0 dsDNA Poxvirus GN3L_Grn1 PF08701.11 AAS51928.2 - 2.5e-24 85.2 20.1 7.2e-24 83.7 20.1 1.8 1 0 0 1 1 1 1 GNL3L/Grn1 putative GTPase MMR_HSR1 PF01926.23 AAS51928.2 - 1.7e-18 66.8 0.1 1.2e-14 54.4 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS51928.2 - 1.5e-09 37.5 0.1 8.6e-09 35.1 0.0 2.0 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AAS51928.2 - 0.00013 22.0 0.1 0.0049 16.8 0.1 2.3 1 1 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 AAS51928.2 - 0.002 17.7 2.0 0.076 12.5 0.0 2.8 3 1 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AAS51928.2 - 0.0034 16.7 0.0 0.015 14.6 0.0 2.0 2 0 0 2 2 2 1 AIG1 family AAA_18 PF13238.6 AAS51928.2 - 0.014 16.0 1.0 0.068 13.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AAS51928.2 - 0.026 14.1 0.3 0.47 10.0 0.0 2.5 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 AAS51928.2 - 0.086 11.8 0.1 0.086 11.8 0.1 2.3 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AAS51928.2 - 0.1 12.7 10.2 0.56 10.2 0.1 3.7 3 2 1 4 4 3 0 Dynamin family Roc PF08477.13 AAS51928.2 - 0.1 12.8 0.1 6.2 7.1 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Nuc_deoxyri_tr2 PF15891.5 AAS51928.2 - 1.4 9.3 0.0 1.4 9.3 0.0 2.4 2 1 1 3 3 3 0 Nucleoside 2-deoxyribosyltransferase like CNDH2_C PF16858.5 AAS51928.2 - 1.5 8.6 13.6 2.6 7.9 13.6 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term UPF0767 PF15990.5 AAS51928.2 - 4.2 7.6 0.0 4.2 7.6 0.0 3.1 3 0 0 3 3 3 0 UPF0767 family LRR_4 PF12799.7 AAS51929.1 - 9.6e-14 51.3 28.6 0.0023 18.3 0.1 6.0 4 2 2 6 6 6 5 Leucine Rich repeats (2 copies) CAP_GLY PF01302.25 AAS51929.1 - 1.1e-13 51.0 0.1 1.8e-13 50.3 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain LRR_6 PF13516.6 AAS51929.1 - 3.1e-07 29.9 14.7 0.16 12.1 0.0 7.2 7 0 0 7 7 7 3 Leucine Rich repeat LRR_8 PF13855.6 AAS51929.1 - 2.5e-05 23.9 20.0 0.051 13.3 1.6 6.0 2 2 4 6 6 6 5 Leucine rich repeat LRR_1 PF00560.33 AAS51929.1 - 0.0037 17.6 14.9 12 7.0 2.3 7.8 5 3 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 AAS51929.1 - 0.0044 16.5 10.7 0.15 11.6 0.5 3.6 2 1 3 5 5 5 3 Leucine-rich repeat Pre-PUA PF17832.1 AAS51930.1 - 6.2e-26 90.9 2.4 1e-25 90.2 2.4 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 AAS51930.1 - 4.7e-20 71.3 0.1 1e-19 70.3 0.0 1.6 2 0 0 2 2 2 1 PUA domain DUF1947 PF09183.10 AAS51930.1 - 0.0034 17.6 0.7 0.0071 16.6 0.3 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF1947) Helicase_C PF00271.31 AAS51931.2 - 4.3e-19 68.9 0.2 1.9e-18 66.8 0.1 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS51931.2 - 1.9e-18 67.1 0.0 5.2e-18 65.6 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS51931.2 - 5.2e-18 65.4 0.0 1.8e-17 63.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 AAS51931.2 - 0.0022 17.7 0.0 0.0058 16.3 0.0 1.7 1 0 0 1 1 1 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 AAS51931.2 - 0.056 13.7 0.0 0.41 10.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain Sec3_C PF09763.9 AAS51932.2 - 8.1e-190 632.7 18.4 1.1e-189 632.3 18.4 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 Sec3-PIP2_bind PF15277.6 AAS51932.2 - 4.5e-23 81.2 0.1 4.5e-23 81.2 0.1 2.4 3 0 0 3 3 3 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps52 PF04129.12 AAS51932.2 - 2.2e-06 26.7 2.0 4.2e-06 25.8 2.0 1.4 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C_2 PF15278.6 AAS51932.2 - 0.002 18.4 1.4 0.014 15.7 0.1 2.8 2 0 0 2 2 2 1 Sec3 exocyst complex subunit F_actin_bind PF08919.10 AAS51932.2 - 0.012 15.7 0.5 0.067 13.3 0.5 2.4 1 0 0 1 1 1 0 F-actin binding NTF2 PF02136.20 AAS51933.1 - 3.7e-37 127.5 0.7 4.1e-37 127.4 0.7 1.0 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain DUF4518 PF15008.6 AAS51933.1 - 0.00044 19.5 0.3 0.0011 18.2 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4518) Glyco_transf_52 PF07922.11 AAS51933.1 - 0.1 11.9 0.1 0.35 10.1 0.0 1.7 1 1 1 2 2 2 0 Glycosyltransferase family 52 DUF4440 PF14534.6 AAS51933.1 - 0.11 12.9 0.0 0.13 12.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) Aim21 PF11489.8 AAS51934.2 - 3.3e-07 29.6 23.6 3.3e-07 29.6 23.6 2.6 1 1 0 2 2 2 2 Altered inheritance of mitochondria protein 21 CCDC23 PF15674.5 AAS51934.2 - 0.16 12.0 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 23 DnaJ-X PF14308.6 AAS51935.2 - 3.2e-74 248.9 0.9 3.2e-74 248.9 0.9 2.3 2 1 0 2 2 2 1 X-domain of DnaJ-containing DnaJ PF00226.31 AAS51935.2 - 3.6e-24 84.7 2.2 1.1e-23 83.1 2.2 1.9 1 0 0 1 1 1 1 DnaJ domain DUF4532 PF15046.6 AAS51935.2 - 0.027 13.7 0.0 0.049 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4532) Peroxin-22 PF12827.7 AAS51935.2 - 0.096 12.6 0.0 0.23 11.4 0.0 1.6 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family RraA-like PF03737.15 AAS51936.1 - 1.8e-30 106.1 0.0 2.3e-30 105.8 0.0 1.1 1 0 0 1 1 1 1 Aldolase/RraA RRM_1 PF00076.22 AAS51937.1 - 1.8e-15 56.5 0.0 3e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ldl_recept_b PF00058.17 AAS51937.1 - 0.13 12.8 0.0 0.33 11.5 0.0 1.7 1 0 0 1 1 1 0 Low-density lipoprotein receptor repeat class B EF-hand_4 PF12763.7 AAS51938.2 - 1.5e-25 89.2 0.0 7.9e-15 54.7 0.0 2.6 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 AAS51938.2 - 1.3e-09 36.9 0.0 0.00025 20.4 0.0 3.6 3 0 0 3 3 3 2 EF hand DUF1720 PF08226.11 AAS51938.2 - 2.2e-08 34.4 28.5 2.2e-08 34.4 28.5 9.0 6 2 3 9 9 9 4 Domain of unknown function (DUF1720) EF-hand_7 PF13499.6 AAS51938.2 - 3.2e-07 30.7 0.0 2.5e-05 24.6 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AAS51938.2 - 9.3e-07 28.3 0.1 0.15 12.1 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 AAS51938.2 - 0.02 14.7 0.0 0.64 9.9 0.0 2.8 2 1 1 3 3 3 0 EF-hand domain pair SRP1_TIP1 PF00660.17 AAS51939.1 - 4.9e-11 42.6 0.0 8.3e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Seripauperin and TIP1 family CDC27 PF09507.10 AAS51939.1 - 3.7 6.8 7.7 4.8 6.5 7.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Mannosyl_trans3 PF11051.8 AAS51940.3 - 2.9e-47 161.3 0.0 3.7e-47 161.0 0.0 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative ARD PF03079.14 AAS51941.1 - 7e-43 146.5 0.0 8.1e-43 146.3 0.0 1.0 1 0 0 1 1 1 1 ARD/ARD' family Cupin_2 PF07883.11 AAS51941.1 - 1.4e-09 37.5 0.1 2.7e-09 36.6 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AAS51941.1 - 1.7e-06 28.0 0.0 2.6e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 AAS51941.1 - 0.025 14.3 0.0 0.038 13.7 0.0 1.3 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.22 AAS51941.1 - 0.041 13.5 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Cupin PQ-loop PF04193.14 AAS51942.2 - 2.3e-11 43.3 18.9 1.6e-09 37.3 2.7 4.0 3 1 0 3 3 3 2 PQ loop repeat Pet127 PF08634.10 AAS51943.1 - 2.9e-102 341.8 0.9 5.1e-102 341.0 0.2 1.7 2 0 0 2 2 2 1 Mitochondrial protein Pet127 TauD PF02668.16 AAS51944.1 - 3.1e-46 158.4 0.0 4.3e-46 157.9 0.0 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AAS51944.1 - 0.00039 21.0 0.0 0.0012 19.5 0.0 1.8 1 1 1 2 2 2 2 Protein of unknown function (DUF971) CsiD PF08943.10 AAS51944.1 - 0.013 14.7 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 CsiD TP6A_N PF04406.14 AAS51945.1 - 2.6e-12 46.5 0.2 5.1e-12 45.6 0.2 1.5 1 0 0 1 1 1 1 Type IIB DNA topoisomerase EMP24_GP25L PF01105.24 AAS51946.1 - 2.7e-35 122.0 0.0 3e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD GPHR_N PF12537.8 AAS51946.1 - 0.033 14.2 0.5 0.19 11.8 0.0 2.3 2 0 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal RPN7 PF10602.9 AAS51947.2 - 3.9e-55 186.2 3.9 3.9e-55 186.2 3.9 1.7 2 0 0 2 2 2 1 26S proteasome subunit RPN7 PCI PF01399.27 AAS51947.2 - 4e-16 59.4 0.4 1.3e-15 57.7 0.2 2.1 3 0 0 3 3 3 1 PCI domain TPR_8 PF13181.6 AAS51947.2 - 0.0042 17.2 0.1 0.02 15.1 0.1 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 AAS51947.2 - 0.014 15.6 0.6 0.075 13.3 0.4 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 AAS51947.2 - 0.015 14.5 0.2 0.031 13.5 0.1 1.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF1955 PF09205.10 AAS51947.2 - 0.021 14.6 1.4 0.034 13.9 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1955) Interferon PF00143.19 AAS51947.2 - 0.035 14.3 0.2 0.089 13.0 0.2 1.6 1 0 0 1 1 1 0 Interferon alpha/beta domain TPR_7 PF13176.6 AAS51947.2 - 0.049 13.7 0.0 1.4 9.1 0.0 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 AAS51947.2 - 0.056 13.6 1.0 0.32 11.2 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ATG16 PF08614.11 AAS51948.2 - 0.0063 16.8 15.5 0.0063 16.8 15.5 2.4 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Spc7 PF08317.11 AAS51948.2 - 0.75 8.6 31.2 0.55 9.1 17.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 AAS51948.2 - 1.4 9.2 38.8 2.5 8.3 9.6 3.2 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 CTP_transf_3 PF02348.19 AAS51948.2 - 2.7 7.8 8.9 0.27 11.1 3.9 1.8 3 0 0 3 3 3 0 Cytidylyltransferase DUF1515 PF07439.11 AAS51948.2 - 4.2 7.4 7.7 5.7 7.0 1.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) RasGAP_C PF03836.15 AAS51948.2 - 4.2 7.5 20.7 0.22 11.6 8.0 2.4 1 1 0 2 2 2 0 RasGAP C-terminus DUF1664 PF07889.12 AAS51948.2 - 6.2 6.9 11.9 7.5 6.6 4.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Nrap_D5 PF17406.2 AAS51949.2 - 9.8e-54 181.5 0.0 1.8e-53 180.6 0.0 1.5 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D2 PF17403.2 AAS51949.2 - 8e-51 171.8 0.2 1.1e-48 164.8 0.1 2.4 2 0 0 2 2 2 2 Nrap protein PAP/OAS-like domain Nrap_D4 PF17405.2 AAS51949.2 - 2.1e-49 167.8 0.3 3.9e-49 166.9 0.3 1.4 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 Nrap PF03813.14 AAS51949.2 - 3.3e-43 147.3 1.0 8.2e-43 146.1 1.0 1.7 1 0 0 1 1 1 1 Nrap protein domain 1 Nrap_D3 PF17404.2 AAS51949.2 - 1.6e-40 138.8 0.0 4.8e-40 137.2 0.0 1.8 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D6 PF17407.2 AAS51949.2 - 1.4e-24 86.8 0.0 2.8e-24 85.8 0.0 1.6 1 0 0 1 1 1 1 Nrap protein domain 6 DUF1746 PF08508.10 AAS51950.2 - 0.0019 18.5 0.0 0.035 14.4 0.0 2.3 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1746) RNA_pol_A_bac PF01000.26 AAS51951.1 - 2.5e-29 101.9 0.0 6.3e-29 100.6 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AAS51951.1 - 7e-20 70.2 0.0 1e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Nop PF01798.18 AAS51952.3 - 7e-44 150.0 0.0 8.4e-44 149.7 0.0 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 AAS51952.3 - 2.1e-13 51.2 0.2 3.6e-13 50.5 0.2 1.3 1 0 0 1 1 1 1 Prp31 C terminal domain T2SSF PF00482.23 AAS51952.3 - 0.035 14.0 1.2 0.072 13.1 0.2 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Pkinase PF00069.25 AAS51953.1 - 1.2e-55 188.7 0.0 7.1e-55 186.2 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51953.1 - 9.6e-28 97.2 0.1 1.2e-18 67.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS51953.1 - 0.00015 20.8 0.4 0.0004 19.5 0.4 1.6 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 AAS51953.1 - 0.00034 21.3 1.8 0.00087 19.9 1.8 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 AAS51953.1 - 0.0017 17.8 0.0 0.014 14.8 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 AAS51953.1 - 0.017 14.5 0.0 0.044 13.1 0.0 1.7 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS51953.1 - 0.067 13.1 0.6 0.35 10.8 0.0 2.4 3 1 1 4 4 4 0 Phosphotransferase enzyme family CwfJ_C_1 PF04677.15 AAS51954.2 - 2.6e-34 117.7 1.1 3.2e-34 117.4 0.1 1.6 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 AAS51954.2 - 6.2e-13 49.5 1.5 1.4e-12 48.4 1.5 1.7 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 2 HIT PF01230.23 AAS51954.2 - 0.014 16.1 0.1 0.032 15.0 0.1 1.5 1 0 0 1 1 1 0 HIT domain RRM_1 PF00076.22 AAS51955.2 - 6.9e-72 237.2 7.9 7.6e-18 64.1 0.0 6.0 5 1 0 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS51955.2 - 1.7e-10 40.6 0.0 0.02 14.8 0.0 4.8 5 0 0 5 5 5 3 Occluded RNA-recognition motif RRM_5 PF13893.6 AAS51955.2 - 9.4e-07 28.5 0.0 0.0008 19.0 0.1 4.3 3 1 1 4 4 4 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS51955.2 - 6.1e-05 23.1 0.1 7.5 6.8 0.0 4.7 4 0 0 4 4 4 2 RNA recognition motif Nup35_RRM_2 PF14605.6 AAS51955.2 - 0.0022 17.9 0.1 13 5.8 0.0 4.7 5 0 0 5 5 5 1 Nup53/35/40-type RNA recognition motif Mito_carr PF00153.27 AAS51956.1 - 1.9e-51 171.9 1.6 1.3e-16 60.2 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein LSM14 PF12701.7 AAS51957.2 - 1.3e-25 89.2 0.1 1.9e-25 88.8 0.1 1.2 1 0 0 1 1 1 1 Scd6-like Sm domain FDF PF09532.10 AAS51957.2 - 1.8e-07 32.0 5.5 0.00051 20.9 0.2 2.2 1 1 1 2 2 2 2 FDF domain SM-ATX PF14438.6 AAS51957.2 - 3e-06 27.3 0.0 4.1e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.22 AAS51957.2 - 0.07 12.8 0.1 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 LSM domain Acetyltransf_1 PF00583.25 AAS51958.1 - 9.4e-09 35.5 0.0 1.3e-08 35.1 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS51958.1 - 3.5e-05 24.1 0.0 5.4e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AAS51958.1 - 5.6e-05 23.0 0.0 0.0001 22.2 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 AAS51958.1 - 0.00024 21.1 0.0 0.00034 20.5 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TPR_7 PF13176.6 AAS51958.1 - 0.061 13.4 0.4 0.62 10.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Leu_Phe_trans PF03588.14 AAS51959.1 - 0.072 12.6 1.3 0.44 10.1 0.0 2.2 2 0 0 2 2 2 0 Leucyl/phenylalanyl-tRNA protein transferase CNH PF00780.22 AAS51960.1 - 0.024 14.3 0.2 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 CNH domain MCM PF00493.23 AAS51961.1 - 9.7e-104 345.3 0.0 1.6e-103 344.7 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AAS51961.1 - 1.6e-32 112.0 0.7 3e-32 111.1 0.7 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AAS51961.1 - 3e-22 78.8 2.4 3.8e-22 78.5 0.7 2.2 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 AAS51961.1 - 2.4e-16 60.2 0.3 1.2e-15 58.0 0.3 2.3 1 1 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AAS51961.1 - 3.6e-08 33.1 0.1 8.5e-06 25.3 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AAS51961.1 - 2.8e-07 30.6 0.0 9.4e-07 28.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_2 PF17863.1 AAS51961.1 - 0.0028 17.5 0.0 0.0067 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain Mg_chelatase_C PF13335.6 AAS51961.1 - 0.0061 17.2 2.1 0.022 15.4 0.1 2.9 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 AAS51961.1 - 0.012 15.5 0.0 0.042 13.7 0.0 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-HYPF PF07503.12 AAS51961.1 - 0.018 14.8 0.1 0.054 13.3 0.1 1.8 1 0 0 1 1 1 0 HypF finger Sigma54_activat PF00158.26 AAS51961.1 - 0.095 12.4 0.1 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_16 PF13191.6 AAS51961.1 - 0.67 10.3 3.1 4.6 7.6 0.0 3.3 2 2 0 3 3 3 0 AAA ATPase domain VPS28 PF03997.12 AAS51963.1 - 2.8e-73 245.6 0.1 3.2e-73 245.4 0.1 1.0 1 0 0 1 1 1 1 VPS28 protein MSA-2c PF12238.8 AAS51963.1 - 0.0057 16.7 0.1 0.0098 15.9 0.1 1.3 1 0 0 1 1 1 1 Merozoite surface antigen 2c EntA_Immun PF08951.10 AAS51963.1 - 0.038 14.3 0.7 0.13 12.7 0.2 2.1 2 0 0 2 2 2 0 Enterocin A Immunity Pox_A12 PF04651.13 AAS51963.1 - 0.057 13.5 0.0 0.089 12.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus A12 protein Pro_isomerase PF00160.21 AAS51964.1 - 1.8e-11 44.6 0.0 2.3e-10 41.0 0.0 2.1 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NIF PF03031.18 AAS51965.2 - 1.9e-38 131.7 0.1 2.8e-38 131.2 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase CTI PF06934.11 AAS51965.2 - 0.033 12.7 4.2 0.045 12.3 4.2 1.1 1 0 0 1 1 1 0 Fatty acid cis/trans isomerase (CTI) Abhydrolase_6 PF12697.7 AAS51966.2 - 1.4e-12 48.7 0.0 3.5e-12 47.4 0.0 1.7 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS51966.2 - 3.7e-09 36.2 0.0 8e-09 35.1 0.0 1.5 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AAS51966.2 - 9e-08 32.1 0.0 3.5e-07 30.1 0.0 1.8 2 0 0 2 2 2 1 alpha/beta hydrolase fold Thioesterase PF00975.20 AAS51966.2 - 0.00057 20.1 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase domain LIDHydrolase PF10230.9 AAS51966.2 - 0.16 11.5 0.0 0.28 10.7 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Say1_Mug180 PF10340.9 AAS51967.1 - 3.5e-27 95.2 0.0 4.7e-27 94.8 0.0 1.0 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_3 PF07859.13 AAS51967.1 - 8.2e-14 52.0 1.6 1.6e-13 51.0 1.4 1.6 1 1 1 2 2 2 1 alpha/beta hydrolase fold Glyco_transf_15 PF01793.16 AAS51968.1 - 9e-80 268.3 0.0 1.1e-79 268.0 0.0 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase CorA PF01544.18 AAS51969.2 - 0.024 14.0 4.0 0.046 13.0 4.0 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF443 PF04276.12 AAS51969.2 - 0.12 12.2 0.3 0.19 11.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF443) FTR1 PF03239.14 AAS51970.1 - 3.2e-93 312.3 9.2 3.8e-93 312.0 9.2 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family CT_A_B PF02626.15 AAS51971.2 - 4.7e-91 305.1 0.0 9e-91 304.2 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain A and B Amidase PF01425.21 AAS51971.2 - 7.1e-89 298.8 0.7 1.3e-88 297.9 0.7 1.4 1 0 0 1 1 1 1 Amidase CPSase_L_D2 PF02786.17 AAS51971.2 - 2.9e-62 209.9 0.0 5.3e-62 209.1 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CT_C_D PF02682.16 AAS51971.2 - 9e-46 156.2 0.0 1.7e-45 155.2 0.0 1.5 1 0 0 1 1 1 1 Carboxyltransferase domain, subdomain C and D Biotin_carb_N PF00289.22 AAS51971.2 - 1.7e-42 144.4 0.0 4.3e-42 143.1 0.0 1.7 1 0 0 1 1 1 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AAS51971.2 - 8.9e-31 106.2 0.0 1.9e-30 105.1 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 AAS51971.2 - 3.7e-16 58.7 2.5 1.2e-15 57.1 2.5 1.9 1 0 0 1 1 1 1 Biotin-requiring enzyme Dala_Dala_lig_C PF07478.13 AAS51971.2 - 1.6e-14 53.9 0.0 3.3e-14 52.9 0.0 1.4 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AAS51971.2 - 1.8e-06 27.6 0.0 4.3e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 AAS51971.2 - 0.00015 21.8 0.0 0.00028 21.0 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain RnfC_N PF13375.6 AAS51971.2 - 0.0049 16.8 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 RnfC Barrel sandwich hybrid domain ATPgrasp_Ter PF15632.6 AAS51971.2 - 0.0077 16.0 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon NQRA PF05896.11 AAS51971.2 - 0.019 14.4 0.2 0.037 13.4 0.2 1.4 1 0 0 1 1 1 0 Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GCV_H PF01597.19 AAS51971.2 - 0.066 13.1 0.7 0.2 11.5 0.2 2.0 2 0 0 2 2 2 0 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.6 AAS51971.2 - 0.069 13.0 1.8 1.8 8.4 0.1 2.8 1 1 1 2 2 2 0 Biotin-lipoyl like AMP-binding PF00501.28 AAS51972.1 - 1.5e-76 257.7 0.0 1.8e-76 257.4 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Glutaredoxin PF00462.24 AAS51973.1 - 1.5e-17 63.6 0.0 2.1e-17 63.0 0.0 1.2 1 0 0 1 1 1 1 Glutaredoxin Exo5 PF09810.9 AAS51974.1 - 1.7e-58 198.9 0.0 2.3e-58 198.5 0.0 1.1 1 0 0 1 1 1 1 Exonuclease V - a 5' deoxyribonuclease PDDEXK_1 PF12705.7 AAS51974.1 - 0.0015 18.5 3.0 0.31 10.9 1.2 2.9 2 1 0 2 2 2 2 PD-(D/E)XK nuclease superfamily TetR_C_11 PF16859.5 AAS51974.1 - 0.019 15.3 2.0 0.21 11.9 0.0 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Cas_Cas4 PF01930.17 AAS51974.1 - 0.14 12.2 0.7 15 5.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF83 RAMP4 PF06624.12 AAS51975.1 - 3.4e-11 43.0 0.1 3.8e-11 42.9 0.1 1.0 1 0 0 1 1 1 1 Ribosome associated membrane protein RAMP4 DUF2401 PF10287.9 AAS51976.1 - 1.3e-92 309.5 1.3 2.1e-92 308.9 1.3 1.3 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AAS51976.1 - 9.6e-28 96.4 0.1 2.8e-27 94.9 0.1 1.9 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) Pkinase PF00069.25 AAS51978.1 - 1.3e-73 247.6 0.0 1.5e-73 247.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS51978.1 - 4.6e-34 117.9 0.0 5.8e-34 117.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS51978.1 - 1.1e-05 24.9 0.0 1.9e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AAS51978.1 - 0.00067 18.7 0.1 0.0048 15.9 0.1 2.0 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AAS51978.1 - 0.0016 18.4 0.3 0.049 13.5 0.1 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 AAS51978.1 - 0.0086 15.4 0.3 0.039 13.3 0.2 2.1 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 AAS51978.1 - 0.16 11.0 0.1 0.25 10.3 0.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 adh_short PF00106.25 AAS51979.2 - 4.2e-35 121.0 0.3 6.7e-35 120.3 0.3 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS51979.2 - 3.4e-21 75.9 0.0 5.4e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS51979.2 - 6.8e-05 22.9 0.0 0.00013 21.9 0.0 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 AAS51979.2 - 0.0037 16.5 0.1 0.0049 16.1 0.1 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Lge1 PF11488.8 AAS51980.1 - 2.4e-18 66.1 4.8 3e-18 65.8 4.8 1.1 1 0 0 1 1 1 1 Transcriptional regulatory protein LGE1 Mito_fiss_reg PF05308.11 AAS51980.1 - 1.1 9.3 10.9 9.2 6.3 5.9 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator CAP_N PF01213.19 AAS51980.1 - 1.4 8.3 21.9 3.7 7.0 1.2 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal LRR_4 PF12799.7 AAS51981.1 - 2.3e-05 24.6 1.0 0.82 10.2 0.6 3.6 2 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AAS51981.1 - 3e-05 23.7 0.4 0.56 10.4 0.0 3.9 4 0 0 4 4 4 2 Leucine Rich repeat LRR_8 PF13855.6 AAS51981.1 - 0.89 9.4 3.7 3.6 7.4 0.0 3.5 3 2 0 3 3 3 0 Leucine rich repeat zf-CCCH PF00642.24 AAS51982.1 - 1.5e-10 40.7 17.2 1.6e-06 27.8 2.9 2.7 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AAS51982.1 - 5.1e-10 39.1 22.5 1.5e-05 24.9 3.5 2.9 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_4 PF18044.1 AAS51982.1 - 3.4e-09 36.3 9.9 0.00019 21.1 0.8 2.7 2 0 0 2 2 2 2 CCCH-type zinc finger Torus PF16131.5 AAS51982.1 - 5.1e-09 36.8 5.3 0.0011 19.6 0.4 2.4 1 1 1 2 2 2 2 Torus domain zf-CCCH_3 PF15663.5 AAS51982.1 - 0.00019 21.6 1.1 0.00036 20.7 1.1 1.4 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 AAS51982.1 - 0.00024 21.5 14.4 0.042 14.3 2.7 2.3 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger TB2_DP1_HVA22 PF03134.19 AAS51983.2 - 3.8e-26 90.8 9.0 5.7e-26 90.3 9.0 1.3 1 0 0 1 1 1 1 TB2/DP1, HVA22 family Rft-1 PF04506.13 AAS51983.2 - 0.0092 14.8 1.0 0.011 14.6 1.0 1.0 1 0 0 1 1 1 1 Rft protein Polysacc_synt_C PF14667.6 AAS51983.2 - 0.035 14.2 7.7 0.051 13.6 7.5 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain Adaptin_N PF01602.20 AAS51984.2 - 1.4e-101 340.6 13.4 1.7e-101 340.4 13.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 AAS51984.2 - 8.4e-08 32.5 0.2 1.7e-07 31.6 0.2 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain KorB PF08535.10 AAS51984.2 - 0.083 12.9 0.1 1.5 8.9 0.0 2.9 3 0 0 3 3 3 0 KorB domain Arrestin_C PF02752.22 AAS51985.2 - 1.4e-08 35.3 5.9 6.1e-07 30.0 4.9 3.0 2 1 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Got1 PF04178.12 AAS51986.2 - 4.6e-32 110.8 12.0 7.7e-32 110.1 12.0 1.3 1 0 0 1 1 1 1 Got1/Sft2-like family TMEM210 PF15195.6 AAS51986.2 - 2.1 8.8 3.7 0.83 10.1 0.5 1.9 2 0 0 2 2 2 0 TMEM210 family DUF2070 PF09843.9 AAS51986.2 - 4.3 5.5 9.9 5.4 5.2 9.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HLH PF00010.26 AAS51987.1 - 1.8e-12 47.0 1.3 1.8e-12 47.0 1.3 2.5 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain Cyclin_N PF00134.23 AAS51988.1 - 1.1e-42 144.7 0.1 1.9e-42 144.0 0.1 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 AAS51988.1 - 7.1e-34 116.4 0.1 1.5e-33 115.4 0.0 1.6 2 0 0 2 2 2 1 Cyclin, C-terminal domain Sas10 PF09368.10 AAS51989.1 - 6.5e-29 100.2 12.3 6.5e-29 100.2 12.3 2.4 3 0 0 3 3 3 1 Sas10 C-terminal domain Sas10_Utp3 PF04000.15 AAS51989.1 - 1.2e-05 25.8 0.0 6.6e-05 23.5 0.0 2.4 1 0 0 1 1 1 1 Sas10/Utp3/C1D family RNA_pol_Rpc4 PF05132.14 AAS51990.2 - 6.7e-26 91.5 0.0 6.7e-26 91.5 0.0 3.0 3 0 0 3 3 3 1 RNA polymerase III RPC4 Trypan_PARP PF05887.11 AAS51990.2 - 1.1 9.2 10.8 20 5.2 0.0 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) APG9 PF04109.16 AAS51991.1 - 9.9e-198 658.0 18.4 1.2e-197 657.7 18.4 1.1 1 0 0 1 1 1 1 Autophagy protein Apg9 Nop14 PF04147.12 AAS51992.1 - 4.3e-179 597.7 46.7 4.8e-99 332.8 15.9 2.1 1 1 1 2 2 2 2 Nop14-like family Peptidase_M16 PF00675.20 AAS51992.1 - 0.15 12.1 5.9 0.053 13.5 0.6 2.8 3 0 0 3 3 3 0 Insulinase (Peptidase family M16) PCI PF01399.27 AAS51993.2 - 1.4e-22 80.2 0.3 5.1e-22 78.4 0.0 2.2 2 0 0 2 2 2 1 PCI domain RPN5_C PF18098.1 AAS51993.2 - 1.6e-15 56.9 3.3 8.9e-15 54.5 3.3 2.4 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN5 C-terminal domain DUF1216 PF06746.11 AAS51993.2 - 0.0024 17.9 0.5 0.012 15.6 0.5 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1216) HALZ PF02183.18 AAS51994.2 - 0.001 19.2 0.4 0.0026 18.0 0.4 1.7 1 0 0 1 1 1 1 Homeobox associated leucine zipper EF_TS PF00889.19 AAS51994.2 - 0.021 14.4 0.1 0.021 14.4 0.1 1.1 1 0 0 1 1 1 0 Elongation factor TS GIT_CC PF16559.5 AAS51994.2 - 0.92 9.4 6.6 0.12 12.3 1.6 2.1 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF2013 PF09431.10 AAS51995.2 - 1.3e-38 132.3 12.3 1.3e-38 132.3 12.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2013) Bromo_TP_like PF17027.5 AAS51995.2 - 0.024 14.8 1.8 0.024 14.8 1.8 2.4 2 1 0 2 2 2 0 Histone-fold protein Tubulin PF00091.25 AAS51996.1 - 1.1e-65 221.6 0.0 1.7e-65 220.9 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AAS51996.1 - 4.2e-29 101.3 0.0 9.1e-29 100.2 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 AAS51996.1 - 5.2e-06 26.8 0.0 1.2e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 AAS51996.1 - 0.019 14.2 0.0 0.03 13.5 0.0 1.3 1 0 0 1 1 1 0 Tubulin like Coatomer_WDAD PF04053.14 AAS51997.1 - 1.1e-132 443.3 2.4 1.5e-132 442.9 2.4 1.2 1 0 0 1 1 1 1 Coatomer WD associated region COPI_C PF06957.11 AAS51997.1 - 1.2e-84 284.4 0.2 1.8e-84 283.9 0.2 1.2 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 AAS51997.1 - 4.6e-39 131.7 18.9 5e-07 30.3 0.3 8.7 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS51997.1 - 1.6e-11 44.4 0.1 7.8e-06 26.1 0.0 5.3 3 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS51997.1 - 2e-05 24.6 0.4 0.7 9.7 0.0 4.3 3 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AAS51997.1 - 0.004 15.9 4.6 2.1 6.9 0.1 3.9 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Ribosomal_L32e PF01655.18 AAS51997.1 - 0.17 12.3 0.0 0.41 11.1 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L32 SH3_10 PF17902.1 AAS51997.1 - 0.18 11.9 0.1 0.46 10.6 0.1 1.6 1 0 0 1 1 1 0 SH3 domain Glyco_hydro_16 PF00722.21 AAS51998.1 - 4e-47 159.9 0.6 6.4e-47 159.3 0.3 1.5 2 0 0 2 2 2 1 Glycosyl hydrolases family 16 Nodulin_late PF07127.11 AAS51998.1 - 0.09 13.1 0.2 0.18 12.2 0.2 1.4 1 0 0 1 1 1 0 Late nodulin protein PNRC PF15365.6 AAS51998.1 - 0.47 10.3 1.7 1 9.3 1.7 1.6 1 0 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif Chitin_bind_1 PF00187.19 AAS51998.1 - 1.6 9.3 12.7 3.2 8.3 12.7 1.5 1 0 0 1 1 1 0 Chitin recognition protein ApbA_C PF08546.11 AAS51999.1 - 4.8e-28 97.9 0.0 7.5e-28 97.2 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 AAS51999.1 - 1.5e-18 66.9 0.0 2.3e-18 66.3 0.0 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox PF00070.27 AAS51999.1 - 0.00041 20.8 0.4 0.0029 18.1 0.4 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AAS51999.1 - 0.0043 17.3 0.3 0.0096 16.1 0.3 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AAS51999.1 - 0.0063 16.1 0.2 0.0097 15.5 0.2 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AAS51999.1 - 0.013 14.8 0.2 0.027 13.7 0.2 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AAS51999.1 - 0.019 14.0 0.5 0.029 13.4 0.5 1.2 1 0 0 1 1 1 0 FAD binding domain Shikimate_DH PF01488.20 AAS51999.1 - 0.04 14.0 0.0 0.099 12.7 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AAS51999.1 - 0.045 14.2 0.0 0.12 12.9 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding ThiF PF00899.21 AAS51999.1 - 0.056 12.8 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 ThiF family FAD_binding_3 PF01494.19 AAS51999.1 - 0.099 11.9 0.2 0.18 11.0 0.2 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 AAS51999.1 - 0.13 11.3 0.3 0.24 10.4 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A FAD_oxidored PF12831.7 AAS51999.1 - 0.27 10.5 0.8 0.42 9.9 0.8 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Ferric_reduct PF01794.19 AAS52000.1 - 1.5e-25 89.7 9.0 1.5e-25 89.7 9.0 2.4 3 1 0 3 3 3 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AAS52000.1 - 9.9e-22 77.1 0.1 2.5e-21 75.8 0.1 1.7 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 AAS52000.1 - 4.9e-10 39.7 0.0 1.4e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain CFEM PF05730.11 AAS52000.1 - 0.099 12.8 2.1 0.18 12.0 2.1 1.3 1 0 0 1 1 1 0 CFEM domain DUF4405 PF14358.6 AAS52000.1 - 5.5 7.6 16.0 1 10.0 1.5 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4405) D123 PF07065.14 AAS52001.1 - 4.8e-108 360.9 0.0 5.5e-108 360.7 0.0 1.0 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 AAS52001.1 - 0.013 15.6 0.0 0.02 14.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 AAS52001.1 - 0.04 13.8 0.0 0.079 12.8 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 2 D123 PF07065.14 AAS52002.1 - 1e-90 304.0 0.0 1.2e-90 303.8 0.0 1.0 1 0 0 1 1 1 1 D123 R2K_3 PF14243.6 AAS52002.1 - 0.028 14.4 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Cpn60_TCP1 PF00118.24 AAS52003.1 - 1.9e-145 485.2 13.7 2.2e-145 485.1 13.7 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CDP-OH_P_transf PF01066.21 AAS52004.2 - 1.6e-15 57.6 0.5 4.8e-15 56.1 0.5 1.8 1 0 0 1 1 1 1 CDP-alcohol phosphatidyltransferase BPL_N PF09825.9 AAS52005.1 - 1.2e-118 396.5 0.0 1.6e-118 396.1 0.0 1.2 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal BPL_LplA_LipB PF03099.19 AAS52005.1 - 9.4e-16 57.9 0.0 1.6e-15 57.2 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 AAS52005.1 - 1.5e-05 24.8 0.0 2.9e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain RNA_pol_Rpb1_1 PF04997.12 AAS52006.2 - 6.2e-115 383.8 0.0 1.2e-114 382.8 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AAS52006.2 - 1.1e-107 359.4 0.3 1.7e-107 358.8 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AAS52006.2 - 2e-78 262.3 0.0 6.8e-78 260.6 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 AAS52006.2 - 1.2e-64 217.6 0.3 3.5e-64 216.2 0.3 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_3 PF04983.18 AAS52006.2 - 1.2e-48 165.0 0.1 8e-48 162.3 0.0 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 AAS52006.2 - 2.4e-48 163.6 3.9 5.2e-48 162.5 3.9 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 AAS52006.2 - 1.1e-35 121.8 0.1 3e-35 120.4 0.1 1.8 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 AAS52006.2 - 1.1e-18 66.5 323.3 0.02 15.2 9.9 15.7 3 1 15 23 23 23 22 RNA polymerase Rpb1 C-terminal repeat Pro_isomerase PF00160.21 AAS52007.1 - 2.4e-44 151.4 0.0 3.4e-44 150.9 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 AAS52007.1 - 4.8e-08 32.5 0.4 1.7e-05 24.4 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 AAS52007.1 - 4.1e-06 26.5 6.6 0.00026 20.8 0.3 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS52007.1 - 0.00051 20.1 0.2 0.0038 17.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS52007.1 - 0.018 15.7 8.1 0.018 15.7 8.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AAS52007.1 - 0.039 14.6 3.9 0.51 11.1 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 AAS52007.1 - 0.11 12.9 1.0 13 6.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 AAS52007.1 - 0.29 11.4 8.1 1.4 9.3 0.4 3.2 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 AAS52007.1 - 0.73 10.0 7.7 0.056 13.6 2.3 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Scm3 PF10384.9 AAS52008.1 - 5.8e-22 77.2 1.0 1.3e-21 76.0 1.0 1.6 1 0 0 1 1 1 1 Centromere protein Scm3 CHCH PF06747.13 AAS52009.1 - 0.002 18.2 2.1 0.0031 17.6 2.1 1.3 1 0 0 1 1 1 1 CHCH domain Sec31 PF11549.8 AAS52010.2 - 3.2e-24 84.5 7.0 4.1e-24 84.2 4.4 2.6 2 0 0 2 2 2 1 Protein transport protein SEC31 SRA1 PF07304.11 AAS52010.2 - 7.2e-09 35.6 4.7 1.6e-08 34.5 0.1 3.0 1 1 1 2 2 2 1 Steroid receptor RNA activator (SRA1) Sec16_C PF12931.7 AAS52010.2 - 3.6e-08 33.4 3.7 9.1e-08 32.1 3.7 1.7 1 1 0 1 1 1 1 Sec23-binding domain of Sec16 ANAPC4_WD40 PF12894.7 AAS52010.2 - 5.5e-08 33.0 0.3 0.15 12.4 0.0 4.3 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS52010.2 - 2.4e-07 31.3 5.9 0.032 15.1 0.1 5.9 5 0 0 5 5 5 2 WD domain, G-beta repeat Prp18 PF02840.15 AAS52010.2 - 0.042 13.9 1.3 0.13 12.3 0.1 2.3 2 1 1 3 3 3 0 Prp18 domain Propep_M14 PF02244.16 AAS52010.2 - 0.21 12.0 5.9 50 4.4 2.8 3.9 3 1 0 3 3 3 0 Carboxypeptidase activation peptide Sugar_tr PF00083.24 AAS52011.2 - 2.8e-118 395.7 30.4 3.2e-118 395.4 30.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS52011.2 - 1.8e-16 60.0 32.3 1.2e-12 47.5 6.1 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily Arf PF00025.21 AAS52013.1 - 5.3e-29 100.9 0.0 6.7e-29 100.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AAS52013.1 - 2.3e-05 23.9 0.1 0.00012 21.6 0.1 1.8 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 AAS52013.1 - 0.00013 21.3 0.0 0.00015 21.0 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit MMR_HSR1 PF01926.23 AAS52013.1 - 0.0003 20.9 0.0 0.0032 17.5 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS52013.1 - 0.00065 20.1 3.4 0.0071 16.7 3.4 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AAS52013.1 - 0.00078 20.0 0.0 0.00098 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 AAS52013.1 - 0.0016 18.6 0.0 0.0035 17.6 0.0 1.5 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AAS52013.1 - 0.0028 17.2 0.0 0.0037 16.9 0.0 1.2 1 0 0 1 1 1 1 Ras family NACHT PF05729.12 AAS52013.1 - 0.0089 16.0 1.1 1.1 9.2 1.1 2.1 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 AAS52013.1 - 0.019 15.2 0.1 0.082 13.2 0.1 1.8 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 AAS52013.1 - 0.056 12.8 0.0 0.22 10.8 0.0 1.8 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region cobW PF02492.19 AAS52013.1 - 0.056 13.0 0.2 8.8 5.9 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AAS52013.1 - 0.082 13.1 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 AAS52013.1 - 0.1 12.4 0.1 0.79 9.5 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Arf PF00025.21 AAS52014.1 - 1.9e-79 265.1 0.0 2.2e-79 264.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 AAS52014.1 - 5.9e-15 55.2 0.0 7.3e-15 54.9 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AAS52014.1 - 2.4e-14 53.6 0.0 3.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 AAS52014.1 - 9.3e-14 51.3 0.0 1e-13 51.2 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AAS52014.1 - 1.6e-13 50.5 1.0 9.3e-10 38.2 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 AAS52014.1 - 6.5e-11 42.0 0.0 8.1e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS52014.1 - 1.1e-05 25.5 0.0 1.7e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRP54 PF00448.22 AAS52014.1 - 0.0078 15.9 0.5 0.015 14.9 0.2 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 AAS52014.1 - 0.014 15.3 0.1 2.4 8.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 AAS52014.1 - 0.026 14.1 0.4 6.4 6.3 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.6 AAS52014.1 - 0.042 14.0 0.3 0.066 13.4 0.3 1.6 1 1 0 1 1 1 0 AAA domain 6PF2K PF01591.18 AAS52014.1 - 0.05 12.9 1.3 0.37 10.1 1.3 2.0 1 1 0 1 1 1 0 6-phosphofructo-2-kinase NACHT PF05729.12 AAS52014.1 - 0.11 12.4 0.6 9.6 6.1 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Thymidylate_kin PF02223.17 AAS52014.1 - 0.13 11.9 1.0 0.97 9.1 0.3 2.0 2 0 0 2 2 2 0 Thymidylate kinase ABC_tran PF00005.27 AAS52014.1 - 0.14 12.7 0.1 0.31 11.6 0.1 1.7 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 AAS52014.1 - 0.15 12.6 0.1 0.22 12.1 0.1 1.4 1 1 0 1 1 1 0 AAA domain Ribosomal_L29 PF00831.23 AAS52015.1 - 2.8e-15 56.0 3.3 2.8e-15 56.0 3.3 2.2 2 0 0 2 2 2 1 Ribosomal L29 protein Phage_sheath_1C PF17482.2 AAS52015.1 - 0.036 14.0 0.1 0.054 13.5 0.1 1.3 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain MRP-L47 PF06984.13 AAS52015.1 - 0.047 13.8 2.5 0.087 13.0 0.8 2.2 1 1 1 2 2 2 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) PilJ PF13675.6 AAS52015.1 - 0.074 13.1 3.9 0.056 13.5 2.0 1.7 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Ufd2P_core PF10408.9 AAS52016.1 - 6.9e-201 669.1 12.8 8.5e-201 668.8 12.8 1.1 1 0 0 1 1 1 1 Ubiquitin elongating factor core U-box PF04564.15 AAS52016.1 - 3.2e-28 97.7 2.6 5.2e-28 97.0 1.2 2.1 2 0 0 2 2 2 1 U-box domain OmpH PF03938.14 AAS52016.1 - 0.14 12.5 1.0 23 5.3 0.0 3.0 3 0 0 3 3 3 0 Outer membrane protein (OmpH-like) R3H PF01424.22 AAS52017.1 - 3.2e-12 46.3 0.4 6.3e-12 45.3 0.4 1.5 1 0 0 1 1 1 1 R3H domain Rho_GDI PF02115.17 AAS52018.1 - 1.8e-61 207.3 2.4 1.9e-61 207.2 2.4 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor MucBP_2 PF17965.1 AAS52018.1 - 0.068 13.7 0.5 1.2 9.8 0.0 2.7 3 1 0 3 3 3 0 Mucin binding domain Metallophos PF00149.28 AAS52019.1 - 2.2e-33 116.5 0.4 3.5e-33 115.8 0.4 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATP-synt_ab PF00006.25 AAS52022.2 - 1.3e-116 387.7 0.0 1.9e-116 387.1 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 AAS52022.2 - 1.3e-45 154.2 0.0 2.4e-45 153.3 0.0 1.5 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AAS52022.2 - 8.7e-16 58.2 2.5 2e-15 57.0 2.5 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain AAA_14 PF13173.6 AAS52022.2 - 0.091 12.8 0.0 0.48 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain Ribosomal_L41 PF05162.13 AAS52023.1 - 1.3e-11 44.3 26.2 1.4e-11 44.3 26.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L41 Mit_KHE1 PF10173.9 AAS52024.1 - 1.8e-52 178.2 0.1 2.5e-52 177.7 0.1 1.2 1 0 0 1 1 1 1 Mitochondrial K+-H+ exchange-related EI24 PF07264.11 AAS52024.1 - 0.069 13.4 0.9 0.1 12.8 0.8 1.4 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF1192 PF06698.11 AAS52024.1 - 1.2 9.3 8.2 1.2 9.2 3.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) MARVEL PF01284.23 AAS52025.1 - 0.0041 17.1 1.7 0.0065 16.5 1.7 1.3 1 0 0 1 1 1 1 Membrane-associating domain IMUP PF15761.5 AAS52025.1 - 0.35 11.6 5.0 54 4.5 0.0 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF4271 PF14093.6 AAS52025.1 - 2.2 8.1 7.4 0.49 10.3 1.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) Cullin PF00888.22 AAS52026.2 - 1.2e-148 496.5 9.9 1.6e-148 496.1 9.9 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 AAS52026.2 - 3.2e-22 78.3 1.1 3.2e-22 78.3 1.1 2.7 3 0 0 3 3 3 1 Cullin protein neddylation domain ANAPC4 PF12896.7 AAS52026.2 - 0.0021 17.6 1.0 0.019 14.4 1.4 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 Baculo_LEF-11 PF06385.12 AAS52026.2 - 0.051 14.1 0.3 15 6.2 0.0 3.5 3 0 0 3 3 3 0 Baculovirus LEF-11 protein Penicillinase_R PF03965.16 AAS52026.2 - 0.057 13.8 2.4 0.19 12.1 0.0 3.0 3 0 0 3 3 3 0 Penicillinase repressor DUF2087 PF09860.9 AAS52026.2 - 0.078 13.1 0.5 2.7 8.2 0.1 3.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2087) HMGL-like PF00682.19 AAS52027.2 - 5.3e-85 285.2 0.1 8.7e-85 284.5 0.1 1.4 1 0 0 1 1 1 1 HMGL-like FliG_N PF14842.6 AAS52027.2 - 0.037 14.6 0.0 0.078 13.5 0.0 1.5 1 0 0 1 1 1 0 FliG N-terminal domain SidE PF12252.8 AAS52027.2 - 0.064 10.8 0.0 0.09 10.3 0.0 1.1 1 0 0 1 1 1 0 Dot/Icm substrate protein WD40 PF00400.32 AAS52028.1 - 1.6e-11 44.6 10.8 0.068 14.1 0.0 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52028.1 - 3.3e-05 24.1 0.0 0.013 15.8 0.0 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 AAS52028.1 - 0.0033 17.3 0.1 0.045 13.7 0.0 2.7 2 0 0 2 2 2 1 PQQ enzyme repeat PQQ_2 PF13360.6 AAS52028.1 - 0.0086 15.7 1.6 0.31 10.6 0.0 2.6 1 1 1 2 2 2 1 PQQ-like domain Frtz PF11768.8 AAS52028.1 - 0.2 9.9 0.0 0.29 9.4 0.0 1.1 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz IATP PF04568.12 AAS52029.1 - 8.2e-14 51.8 2.3 9.3e-14 51.6 2.3 1.1 1 0 0 1 1 1 1 Mitochondrial ATPase inhibitor, IATP DUF2986 PF11661.8 AAS52029.1 - 0.084 13.4 1.9 0.15 12.6 1.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2986) SlyX PF04102.12 AAS52029.1 - 0.3 11.7 7.2 0.58 10.8 7.2 1.4 1 0 0 1 1 1 0 SlyX PspB PF06667.12 AAS52029.1 - 0.32 11.1 3.1 0.43 10.7 3.1 1.2 1 0 0 1 1 1 0 Phage shock protein B XhlA PF10779.9 AAS52029.1 - 1.2 9.4 4.3 1.3 9.3 3.4 1.5 1 1 0 1 1 1 0 Haemolysin XhlA DivIC PF04977.15 AAS52029.1 - 1.7 8.5 9.9 2.9 7.7 9.7 1.6 1 1 0 1 1 1 0 Septum formation initiator tRNA_m1G_MT PF01746.21 AAS52030.1 - 2.5e-34 118.7 0.3 5.4e-34 117.6 0.0 1.7 2 0 0 2 2 2 1 tRNA (Guanine-1)-methyltransferase PTCB-BRCT PF12738.7 AAS52030.1 - 0.1 12.6 2.3 0.29 11.1 0.0 2.6 3 0 0 3 3 3 0 twin BRCT domain Rep_fac_C PF08542.11 AAS52031.1 - 7e-22 77.6 0.0 9.8e-21 74.0 0.0 2.3 2 0 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 AAS52031.1 - 7.5e-14 52.3 0.0 2.2e-13 50.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AAS52031.1 - 1.7e-13 50.7 0.0 1.5e-10 41.1 0.1 2.2 1 1 1 2 2 2 2 DNA polymerase III, delta subunit AAA_16 PF13191.6 AAS52031.1 - 1.6e-07 31.9 0.0 2.2e-05 24.9 0.0 2.4 1 1 1 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 AAS52031.1 - 3.6e-07 30.3 0.0 5.9e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AAS52031.1 - 7.9e-06 26.2 0.2 0.043 14.1 0.1 2.7 2 1 1 3 3 3 2 AAA domain AAA_3 PF07726.11 AAS52031.1 - 1.1e-05 25.3 0.0 2.5e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AAS52031.1 - 1.9e-05 24.4 0.0 5.9e-05 22.9 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Viral_helicase1 PF01443.18 AAS52031.1 - 3.3e-05 23.8 0.0 8.4e-05 22.4 0.0 1.6 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 AAS52031.1 - 6.4e-05 23.0 0.0 0.00019 21.4 0.0 1.8 1 1 1 2 2 2 1 Rad17 P-loop domain DNA_pol3_delta PF06144.13 AAS52031.1 - 0.00012 21.9 0.3 0.00018 21.4 0.3 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Mg_chelatase PF01078.21 AAS52031.1 - 0.00034 20.1 0.0 0.0047 16.3 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI TniB PF05621.11 AAS52031.1 - 0.0017 17.8 0.0 1.1 8.6 0.0 2.3 2 0 0 2 2 2 2 Bacterial TniB protein AAA_assoc_2 PF16193.5 AAS52031.1 - 0.0026 18.0 0.0 0.0091 16.3 0.0 2.0 2 0 0 2 2 2 1 AAA C-terminal domain MeaB PF03308.16 AAS52031.1 - 0.0078 15.2 0.0 0.053 12.5 0.0 2.2 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_19 PF13245.6 AAS52031.1 - 0.013 15.8 0.1 0.052 13.9 0.1 2.1 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AAS52031.1 - 0.037 13.9 0.1 0.21 11.5 0.0 2.1 1 1 1 2 2 2 0 NTPase DEAD PF00270.29 AAS52031.1 - 0.04 13.7 0.2 0.41 10.4 0.2 2.7 1 1 1 2 2 2 0 DEAD/DEAH box helicase AAA_24 PF13479.6 AAS52031.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 AAS52031.1 - 0.059 13.1 0.0 0.086 12.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AAS52031.1 - 0.087 12.5 0.0 0.27 10.9 0.0 1.8 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 AAS52031.1 - 0.095 11.8 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain SRP54 PF00448.22 AAS52031.1 - 0.099 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain KTI12 PF08433.10 AAS52031.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.5 1 1 0 1 1 1 0 Chromatin associated protein KTI12 AAA_7 PF12775.7 AAS52031.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region ATP_bind_2 PF03668.15 AAS52031.1 - 0.21 10.9 0.8 20 4.3 0.1 2.9 2 1 1 3 3 3 0 P-loop ATPase protein family Vps52 PF04129.12 AAS52032.2 - 2.9e-134 448.6 11.1 3.9e-134 448.2 11.1 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family Mer2 PF09074.10 AAS52032.2 - 0.012 15.4 0.6 0.045 13.6 0.2 2.1 1 1 0 1 1 1 0 Mer2 UvrD-helicase PF00580.21 AAS52033.1 - 1.2e-34 120.2 2.7 6.9e-17 61.9 0.0 3.5 3 2 0 4 4 4 2 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AAS52033.1 - 8.2e-28 97.8 0.0 4.3e-27 95.4 0.0 2.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 AAS52033.1 - 2.2e-27 96.2 0.0 6.5e-27 94.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 AAS52033.1 - 8.1e-10 38.8 0.0 0.0075 16.0 0.0 3.2 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 AAS52033.1 - 1.3e-09 37.7 0.0 3e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_11 PF13086.6 AAS52033.1 - 3.1e-07 30.4 0.4 3.2e-06 27.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS52033.1 - 1.9e-05 24.5 0.0 0.027 14.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 AAS52033.1 - 0.002 18.1 0.1 2.6 8.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain DEAD PF00270.29 AAS52033.1 - 0.11 12.2 0.1 0.37 10.5 0.0 1.9 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF2075 PF09848.9 AAS52033.1 - 0.29 10.3 4.0 2.9 7.0 0.1 3.1 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2075) YL1 PF05764.13 AAS52034.1 - 6.2e-45 154.2 30.4 6.2e-45 154.2 30.4 2.5 3 0 0 3 3 3 1 YL1 nuclear protein YL1_C PF08265.11 AAS52034.1 - 7.8e-11 41.5 0.1 1.5e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 YL1 nuclear protein C-terminal domain TMEM117 PF15113.6 AAS52034.1 - 0.23 10.4 0.1 0.34 9.8 0.1 1.1 1 0 0 1 1 1 0 TMEM117 protein family Methyltransf_23 PF13489.6 AAS52035.1 - 1.8e-24 86.5 0.0 2.5e-24 86.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS52035.1 - 6e-19 68.5 0.0 1.2e-18 67.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS52035.1 - 7.6e-17 61.8 0.0 1.4e-16 61.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS52035.1 - 1.5e-16 60.6 0.0 2.2e-16 60.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS52035.1 - 1.8e-15 57.5 0.0 3.4e-15 56.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AAS52035.1 - 4.9e-08 32.6 0.0 6.5e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase NodS PF05401.11 AAS52035.1 - 8.8e-07 28.7 0.0 1.3e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) MetW PF07021.12 AAS52035.1 - 1.5e-06 27.9 0.0 3.8e-06 26.6 0.0 1.6 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW PrmA PF06325.13 AAS52035.1 - 2.1e-06 27.4 0.0 3.2e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AAS52035.1 - 1.8e-05 24.3 0.0 3.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.12 AAS52035.1 - 2.8e-05 23.4 0.0 4.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 DREV methyltransferase Ubie_methyltran PF01209.18 AAS52035.1 - 8.7e-05 22.0 0.0 0.00013 21.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_32 PF13679.6 AAS52035.1 - 0.00032 20.7 0.0 0.00053 20.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 AAS52035.1 - 0.0041 17.1 0.0 0.0065 16.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 AAS52035.1 - 0.032 14.1 0.0 0.2 11.5 0.0 2.2 2 1 0 2 2 2 0 Hypothetical methyltransferase Snf7 PF03357.21 AAS52036.1 - 3.1e-37 127.8 12.3 4.1e-37 127.4 12.3 1.1 1 0 0 1 1 1 1 Snf7 YlqD PF11068.8 AAS52036.1 - 0.00065 20.1 7.3 0.00065 20.1 7.3 2.2 1 1 2 3 3 3 1 YlqD protein TraB PF01963.17 AAS52036.1 - 0.0023 17.9 11.6 0.0034 17.3 11.6 1.2 1 0 0 1 1 1 1 TraB family Fib_alpha PF08702.10 AAS52036.1 - 0.031 14.4 12.2 0.16 12.1 0.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF2972 PF11186.8 AAS52036.1 - 0.084 12.8 2.0 0.13 12.1 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) TMF_DNA_bd PF12329.8 AAS52036.1 - 0.12 12.4 17.2 0.19 11.8 3.6 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Jnk-SapK_ap_N PF09744.9 AAS52036.1 - 0.14 12.4 16.0 0.41 10.8 0.5 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF2203 PF09969.9 AAS52036.1 - 0.14 12.8 5.9 0.49 11.1 0.8 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fmp27_WPPW PF10359.9 AAS52036.1 - 0.16 10.8 8.4 0.28 10.0 8.4 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Cep57_MT_bd PF06657.13 AAS52036.1 - 0.26 11.7 10.0 0.16 12.4 2.6 2.6 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF16 PF01519.16 AAS52036.1 - 0.31 11.6 11.7 0.47 11.0 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 AAS52036.1 - 0.31 11.2 11.8 0.17 12.1 9.4 1.8 1 1 1 2 2 2 0 Tropomyosin like DUF1664 PF07889.12 AAS52036.1 - 0.35 10.9 12.4 0.4 10.7 2.3 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 AAS52036.1 - 0.47 10.7 13.0 8.6 6.6 8.6 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 LPP PF04728.13 AAS52036.1 - 0.5 10.8 0.1 0.5 10.8 0.1 3.5 3 1 0 3 3 2 0 Lipoprotein leucine-zipper DUF948 PF06103.11 AAS52036.1 - 0.7 10.2 6.5 14 6.1 0.0 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 AAS52036.1 - 0.74 9.3 13.3 2 8.0 0.7 3.1 1 1 2 3 3 3 0 fzo-like conserved region Not3 PF04065.15 AAS52036.1 - 1.1 8.7 10.1 2.3 7.6 8.6 1.8 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component Spc7 PF08317.11 AAS52036.1 - 1.5 7.7 16.1 4.5 6.1 16.1 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein OmpH PF03938.14 AAS52036.1 - 1.9 8.8 24.0 0.18 12.1 11.8 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DASH_Dam1 PF08653.10 AAS52036.1 - 2.8 7.8 4.8 4.6 7.1 0.2 3.1 3 1 0 3 3 3 0 DASH complex subunit Dam1 FAM76 PF16046.5 AAS52036.1 - 3.3 7.0 10.7 4.5 6.5 10.0 1.6 1 1 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 AAS52036.1 - 3.9 6.5 14.9 0.74 8.8 0.4 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 CLZ PF16526.5 AAS52036.1 - 4.3 7.8 16.0 1.2 9.5 1.3 3.3 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4407 PF14362.6 AAS52036.1 - 5.9 6.2 15.0 12 5.1 15.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) tRNA-synt_1b PF00579.25 AAS52037.1 - 7.2e-18 64.9 0.0 6.5e-12 45.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (W and Y) DHBP_synthase PF00926.19 AAS52038.1 - 1.4e-80 269.4 1.3 1.5e-80 269.2 1.3 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase A_deaminase PF00962.22 AAS52039.1 - 1.3e-18 67.4 0.0 5.8e-08 32.4 0.0 3.0 2 1 0 2 2 2 2 Adenosine/AMP deaminase NAT PF04768.13 AAS52040.1 - 3.5e-52 176.5 0.0 5.9e-52 175.7 0.0 1.4 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase Sld5 PF05916.11 AAS52041.1 - 1.3e-20 73.8 0.5 1.9e-20 73.3 0.5 1.2 1 0 0 1 1 1 1 GINS complex protein CDC45 PF02724.14 AAS52042.1 - 0.0017 16.7 20.4 0.002 16.5 20.4 1.1 1 0 0 1 1 1 1 CDC45-like protein SAPS PF04499.15 AAS52042.1 - 0.0047 15.8 2.3 0.0057 15.5 2.3 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DUF2207 PF09972.9 AAS52042.1 - 0.051 12.3 2.5 0.087 11.6 2.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EI24 PF07264.11 AAS52042.1 - 0.062 13.5 20.0 0.18 12.1 19.8 1.8 1 1 1 2 2 2 0 Etoposide-induced protein 2.4 (EI24) RNA_pol_Rpc4 PF05132.14 AAS52042.1 - 3.8 7.9 5.4 5.8 7.3 5.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 SpoIIIAH PF12685.7 AAS52042.1 - 6.4 6.5 12.3 9.2 6.0 12.3 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Peptidase_M28 PF04389.17 AAS52043.1 - 3.2e-41 141.2 0.0 4.3e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 AAS52043.1 - 2.6e-09 37.0 0.0 6e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 PA domain Peptidase_M20 PF01546.28 AAS52043.1 - 0.0002 21.1 0.0 0.00039 20.2 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 AAS52043.1 - 0.074 12.0 0.0 0.15 11.1 0.0 1.5 1 1 0 1 1 1 0 M42 glutamyl aminopeptidase DnaJ PF00226.31 AAS52044.2 - 2e-20 72.6 2.3 2e-20 72.6 2.3 2.4 2 0 0 2 2 2 1 DnaJ domain TPR_8 PF13181.6 AAS52044.2 - 0.0067 16.6 0.1 0.11 12.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TFIIA PF03153.13 AAS52044.2 - 0.016 15.2 10.3 0.022 14.8 10.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ssDNA_DBD PF18333.1 AAS52044.2 - 0.041 14.0 0.8 0.041 14.0 0.8 3.0 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain TERB2 PF15101.6 AAS52044.2 - 0.15 12.1 6.4 0.29 11.2 6.4 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2115 PF09888.9 AAS52044.2 - 1.6 9.2 6.4 0.3 11.6 1.8 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Sulfotransfer_3 PF13469.6 AAS52045.2 - 0.071 13.5 0.2 0.26 11.7 0.0 1.8 2 0 0 2 2 2 0 Sulfotransferase family PG_binding_1 PF01471.18 AAS52046.2 - 0.0041 17.3 0.1 0.054 13.7 0.0 2.7 3 0 0 3 3 3 1 Putative peptidoglycan binding domain HMMR_N PF15905.5 AAS52046.2 - 0.45 9.9 4.6 0.72 9.3 4.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal V_ATPase_I PF01496.19 AAS52047.2 - 2.7e-299 994.8 1.5 3.1e-299 994.6 1.5 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Transposase_24 PF03004.14 AAS52047.2 - 0.066 13.3 0.3 0.16 12.1 0.3 1.6 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) HSP70 PF00012.20 AAS52048.1 - 3.5e-46 157.6 0.2 3.5e-46 157.6 0.2 2.0 2 1 0 2 2 2 1 Hsp70 protein RabGAP-TBC PF00566.18 AAS52051.1 - 1.8e-38 132.4 0.0 2.3e-38 132.0 0.0 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Cu-oxidase_2 PF07731.14 AAS52052.1 - 9.2e-49 164.7 5.6 6.7e-42 142.5 0.4 2.8 2 1 0 2 2 2 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AAS52052.1 - 7.7e-39 132.4 7.7 1.7e-37 128.1 0.6 4.2 4 1 1 5 5 5 2 Multicopper oxidase Cu-oxidase PF00394.22 AAS52052.1 - 1.5e-32 112.9 10.2 7.7e-32 110.6 1.4 4.5 4 1 1 5 5 5 1 Multicopper oxidase PRA-PH PF01503.17 AAS52053.1 - 0.086 13.3 0.1 0.23 11.9 0.1 1.8 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase Pox_A22 PF04848.13 AAS52053.1 - 0.11 12.6 0.3 0.24 11.5 0.3 1.5 1 0 0 1 1 1 0 Poxvirus A22 protein CENP-B_dimeris PF09026.10 AAS52053.1 - 0.34 11.3 3.3 1.1 9.8 3.3 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4448 PF14610.6 AAS52054.1 - 1.2e-47 162.1 0.0 1.8e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Sen15 PF09631.10 AAS52055.1 - 5.7e-26 90.7 0.0 6.5e-26 90.5 0.0 1.0 1 0 0 1 1 1 1 Sen15 protein Tom37_C PF11801.8 AAS52056.1 - 1.3e-39 135.5 0.0 1.8e-39 135.0 0.0 1.2 1 0 0 1 1 1 1 Tom37 C-terminal domain Tom37 PF10568.9 AAS52056.1 - 1.1e-24 87.1 0.1 2.6e-24 85.9 0.1 1.6 1 0 0 1 1 1 1 Outer mitochondrial membrane transport complex protein Suf PF05843.14 AAS52057.1 - 5.4e-56 190.7 9.8 2.6e-51 175.4 7.6 4.2 5 1 1 6 6 6 2 Suppressor of forked protein (Suf) ArgJ PF01960.18 AAS52058.2 - 4.8e-139 463.3 4.6 5.5e-139 463.1 4.6 1.0 1 0 0 1 1 1 1 ArgJ family Sugar_tr PF00083.24 AAS52059.1 - 3.8e-118 395.2 15.4 4.4e-118 395.0 15.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS52059.1 - 2.9e-20 72.5 26.2 1.3e-16 60.5 7.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily OppC_N PF12911.7 AAS52059.1 - 0.021 14.8 0.3 0.021 14.8 0.3 2.8 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C DUF2530 PF10745.9 AAS52059.1 - 0.046 14.0 2.7 0.35 11.1 0.3 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) HA2 PF04408.23 AAS52060.1 - 4.5e-21 75.2 0.0 8.3e-21 74.3 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AAS52060.1 - 3.9e-12 46.3 0.0 1.5e-11 44.4 0.0 2.1 2 0 0 2 2 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AAS52060.1 - 1.3e-10 41.6 0.0 4.1e-10 40.0 0.0 1.9 2 0 0 2 2 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AAS52060.1 - 2.9e-10 40.2 0.0 4.9e-10 39.5 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS52060.1 - 1.1e-05 25.7 0.1 2.6e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS52060.1 - 1.2e-05 25.1 0.0 1.9e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AAS52060.1 - 0.00052 19.7 0.2 0.0061 16.2 0.2 2.2 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_19 PF13245.6 AAS52060.1 - 0.001 19.4 0.0 0.0019 18.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 AAS52060.1 - 0.0031 17.4 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Helicase AAA_25 PF13481.6 AAS52060.1 - 0.0061 16.1 0.3 0.041 13.5 0.0 2.4 2 1 1 3 3 3 1 AAA domain AAA_29 PF13555.6 AAS52060.1 - 0.01 15.6 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 AAS52060.1 - 0.011 15.2 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 AAS52060.1 - 0.02 13.9 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 AAS52060.1 - 0.045 14.3 0.0 0.087 13.3 0.0 1.5 1 0 0 1 1 1 0 ABC transporter DUF2075 PF09848.9 AAS52060.1 - 0.047 12.9 0.0 0.073 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 AAS52060.1 - 0.052 13.9 1.3 0.1 13.0 0.2 2.1 2 1 0 2 2 1 0 AAA ATPase domain AAA_23 PF13476.6 AAS52060.1 - 0.053 14.0 0.0 0.094 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AAS52060.1 - 0.076 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 AAS52060.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Herpes_UL49_2 PF04823.12 AAS52060.1 - 0.11 12.6 0.5 0.23 11.6 0.5 1.5 1 0 0 1 1 1 0 Herpesvirus UL49 tegument protein FtsK_SpoIIIE PF01580.18 AAS52060.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_15 PF13175.6 AAS52060.1 - 0.32 10.7 0.0 0.44 10.2 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain SUR7 PF06687.12 AAS52061.1 - 7.6e-26 91.1 11.5 8.9e-26 90.8 11.5 1.1 1 0 0 1 1 1 1 SUR7/PalI family GPR_Gpa2_C PF11970.8 AAS52061.1 - 8.3 6.6 7.7 4.2 7.5 3.5 2.3 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term AEP1 PF17049.5 AAS52062.1 - 3.7e-95 319.3 0.0 2.1e-93 313.6 0.0 2.0 1 1 0 1 1 1 1 ATPase expression protein 1 Tht1 PF04163.12 AAS52063.2 - 5.9e-38 131.0 13.1 1.1e-33 116.9 0.1 2.1 1 1 1 2 2 2 2 Tht1-like nuclear fusion protein Apolipoprotein PF01442.18 AAS52063.2 - 4e-10 39.9 1.4 2.9e-05 24.0 0.1 2.4 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain KxDL PF10241.9 AAS52063.2 - 7.1e-05 23.0 1.3 0.14 12.4 0.1 2.8 2 0 0 2 2 2 2 Uncharacterized conserved protein DUF2408 PF10303.9 AAS52063.2 - 0.001 19.6 3.3 0.03 14.9 0.2 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2408) Baculo_PEP_C PF04513.12 AAS52063.2 - 0.0022 18.1 19.1 0.037 14.1 1.5 4.0 2 1 3 5 5 5 3 Baculovirus polyhedron envelope protein, PEP, C terminus ApoLp-III PF07464.11 AAS52063.2 - 0.0027 17.8 2.5 0.77 9.8 0.2 2.8 2 1 0 2 2 2 2 Apolipophorin-III precursor (apoLp-III) Tektin PF03148.14 AAS52063.2 - 0.0038 16.0 4.7 0.0094 14.7 0.5 2.2 2 0 0 2 2 2 1 Tektin family Fzo_mitofusin PF04799.13 AAS52063.2 - 0.0052 16.3 2.2 0.44 10.1 0.3 2.5 2 0 0 2 2 2 1 fzo-like conserved region DUF16 PF01519.16 AAS52063.2 - 0.022 15.2 1.2 3.2 8.3 0.0 2.9 2 1 1 3 3 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 AAS52063.2 - 0.035 14.1 8.7 0.16 12.0 0.7 3.0 3 1 0 3 3 2 0 Protein of unknown function (DUF1664) COG2 PF06148.11 AAS52063.2 - 0.041 14.0 6.4 1.2 9.3 1.2 3.2 2 2 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FlaC_arch PF05377.11 AAS52063.2 - 0.045 14.2 7.8 0.084 13.3 1.3 3.3 3 1 0 3 3 2 0 Flagella accessory protein C (FlaC) Cep57_MT_bd PF06657.13 AAS52063.2 - 0.048 14.1 1.6 2.9 8.4 0.2 2.7 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 UBN_AB PF14075.6 AAS52063.2 - 0.058 13.1 1.0 1.4 8.6 0.1 2.5 2 1 0 2 2 2 0 Ubinuclein conserved middle domain FliJ PF02050.16 AAS52063.2 - 0.073 13.3 0.9 4.9 7.4 0.5 2.5 2 0 0 2 2 2 0 Flagellar FliJ protein Syntaxin-6_N PF09177.11 AAS52063.2 - 0.074 13.6 5.2 2.6 8.7 0.3 2.8 2 1 0 2 2 2 0 Syntaxin 6, N-terminal MIP-T3_C PF17749.1 AAS52063.2 - 0.076 13.0 3.3 0.47 10.4 1.1 2.6 2 0 0 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region XhlA PF10779.9 AAS52063.2 - 0.077 13.2 0.8 1.1 9.5 0.0 2.6 2 0 0 2 2 2 0 Haemolysin XhlA CENP-F_leu_zip PF10473.9 AAS52063.2 - 0.16 12.0 2.1 9.8 6.2 0.2 2.5 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 RasGAP_C PF03836.15 AAS52063.2 - 0.16 12.1 2.1 2.4 8.3 0.1 2.7 2 1 0 2 2 2 0 RasGAP C-terminus Taxilin PF09728.9 AAS52063.2 - 0.28 10.3 2.2 3.5 6.7 0.3 2.2 2 0 0 2 2 2 0 Myosin-like coiled-coil protein Tropomyosin_1 PF12718.7 AAS52063.2 - 0.29 11.3 1.7 0.54 10.4 0.2 2.0 2 0 0 2 2 2 0 Tropomyosin like DUF4618 PF15397.6 AAS52063.2 - 0.34 10.3 6.9 0.42 10.0 1.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF948 PF06103.11 AAS52063.2 - 0.41 10.9 10.1 5.9 7.2 0.5 3.7 1 1 3 4 4 4 0 Bacterial protein of unknown function (DUF948) BLOC1_2 PF10046.9 AAS52063.2 - 0.55 10.6 5.8 0.84 10.0 0.5 3.2 2 2 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 AAS52063.2 - 0.87 9.6 7.6 1.6 8.8 1.1 2.8 1 1 2 3 3 3 0 Laminin Domain II DUF1043 PF06295.12 AAS52063.2 - 1.3 9.1 4.0 5.8 6.9 0.1 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF1043) COG5 PF10392.9 AAS52063.2 - 1.3 9.2 12.7 2.2 8.5 0.4 4.1 2 1 3 5 5 4 0 Golgi transport complex subunit 5 Exonuc_VII_L PF02601.15 AAS52063.2 - 1.3 8.5 4.7 36 3.8 4.7 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Apq12 PF12716.7 AAS52063.2 - 2.1 8.3 11.9 0.79 9.7 6.8 2.3 1 1 1 2 2 2 0 Nuclear pore assembly and biogenesis DUF4795 PF16043.5 AAS52063.2 - 5.2 6.6 8.4 3.6 7.1 0.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Endonuclease_NS PF01223.23 AAS52064.1 - 1e-66 225.0 0.0 1.1e-66 224.8 0.0 1.0 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease Kinesin PF00225.23 AAS52065.1 - 3.1e-101 338.6 0.0 5.4e-101 337.9 0.0 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AAS52065.1 - 3e-24 85.7 0.0 2e-23 83.0 0.0 2.3 3 0 0 3 3 3 1 Microtubule binding GOLGA2L5 PF15070.6 AAS52065.1 - 2.7e-05 23.1 19.5 4e-05 22.5 19.5 1.1 1 0 0 1 1 1 1 Putative golgin subfamily A member 2-like protein 5 Rootletin PF15035.6 AAS52065.1 - 0.13 12.3 22.7 0.1 12.6 18.9 2.4 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF496 PF04363.12 AAS52065.1 - 0.43 10.6 4.8 0.1 12.6 0.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF496) bZIP_1 PF00170.21 AAS52065.1 - 4.5 7.4 22.0 0.31 11.2 3.7 4.6 2 2 1 4 4 4 0 bZIP transcription factor DivIC PF04977.15 AAS52065.1 - 5.2 6.9 25.6 0.1 12.3 3.3 4.7 3 1 2 5 5 5 0 Septum formation initiator ADIP PF11559.8 AAS52065.1 - 8.4 6.5 23.2 4.2 7.5 1.6 2.8 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding V-ATPase_C PF03223.15 AAS52066.1 - 3.5e-89 299.8 0.0 1.7e-88 297.5 0.0 1.8 1 1 0 1 1 1 1 V-ATPase subunit C EF1G PF00647.19 AAS52067.2 - 1.5e-44 150.4 0.0 2.7e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Elongation factor 1 gamma, conserved domain GST_C PF00043.25 AAS52067.2 - 3.9e-09 36.6 0.0 3.9e-09 36.6 0.0 2.5 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 AAS52067.2 - 6e-07 29.7 0.0 1.7e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 AAS52067.2 - 0.0018 18.2 0.0 0.0039 17.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 AAS52067.2 - 0.13 12.7 0.0 0.25 11.8 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain MMR_HSR1_Xtn PF16897.5 AAS52067.2 - 0.13 12.2 0.1 0.28 11.2 0.1 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SURF6 PF04935.12 AAS52068.1 - 1.4e-47 162.1 45.6 1.4e-47 162.1 45.6 2.5 2 1 0 2 2 2 1 Surfeit locus protein 6 RRP14 PF15459.6 AAS52068.1 - 1.6e-11 44.6 1.3 1.6e-11 44.6 1.3 6.5 4 3 1 5 5 5 1 60S ribosome biogenesis protein Rrp14 PPR_long PF17177.4 AAS52069.2 - 1.4e-05 24.6 0.3 0.0015 18.0 0.0 2.4 2 0 0 2 2 2 2 Pentacotripeptide-repeat region of PRORP Peptidase_M75 PF09375.10 AAS52069.2 - 0.018 14.5 0.1 0.035 13.6 0.1 1.4 1 0 0 1 1 1 0 Imelysin IpaB_EvcA PF03278.13 AAS52069.2 - 0.12 12.1 0.2 0.35 10.6 0.2 1.7 1 0 0 1 1 1 0 IpaB/EvcA family PPR_2 PF13041.6 AAS52069.2 - 0.78 10.0 5.0 15 5.9 0.0 4.4 4 1 1 5 5 5 0 PPR repeat family TUG-UBL1 PF11470.8 AAS52070.2 - 1e-21 76.9 0.0 3.6e-21 75.2 0.0 2.0 2 0 0 2 2 2 1 TUG ubiquitin-like domain UBX PF00789.20 AAS52070.2 - 1e-13 51.3 0.2 3.4e-13 49.6 0.2 1.9 1 0 0 1 1 1 1 UBX domain RA PF00788.23 AAS52070.2 - 0.0065 17.1 0.0 0.046 14.4 0.0 2.4 2 0 0 2 2 2 1 Ras association (RalGDS/AF-6) domain Ank_2 PF12796.7 AAS52071.1 - 7.2e-20 71.4 0.1 1.9e-11 44.4 0.2 3.4 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 AAS52071.1 - 2.6e-17 62.9 0.7 2.6e-09 37.4 0.2 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 AAS52071.1 - 2.5e-15 55.0 1.2 0.0047 17.3 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 AAS52071.1 - 7.8e-15 54.6 3.4 3.5e-05 24.0 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 AAS52071.1 - 1.1e-10 41.5 2.4 0.00046 20.4 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ldh_1_C PF02866.18 AAS52072.1 - 1.8e-51 174.4 0.0 3e-51 173.7 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 AAS52072.1 - 1.1e-41 142.2 0.0 1.5e-41 141.7 0.0 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain 3Beta_HSD PF01073.19 AAS52072.1 - 9.9e-05 21.5 0.0 0.00016 20.8 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 AAS52072.1 - 0.011 15.6 0.2 0.026 14.4 0.2 1.7 1 1 0 1 1 1 0 NAD(P)H-binding Glyco_hydro_4 PF02056.16 AAS52072.1 - 0.07 12.7 0.0 0.32 10.5 0.0 1.9 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase ParBc PF02195.18 AAS52073.1 - 8.3e-16 58.1 0.0 1e-15 57.8 0.0 1.1 1 0 0 1 1 1 1 ParB-like nuclease domain G-alpha PF00503.20 AAS52074.1 - 2e-110 369.3 0.0 2.4e-110 369.1 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 AAS52074.1 - 1.9e-15 56.7 0.7 2.6e-10 40.1 0.0 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS52074.1 - 0.00021 20.7 0.3 0.016 14.6 0.0 2.2 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AAS52074.1 - 0.039 13.5 0.0 0.39 10.2 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AAS52074.1 - 0.054 13.6 0.0 2.9 8.0 0.0 2.6 3 0 0 3 3 3 0 50S ribosome-binding GTPase Roc PF08477.13 AAS52074.1 - 0.15 12.3 0.1 6.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cyto_heme_lyase PF01265.17 AAS52075.2 - 4.1e-39 134.9 11.7 1.6e-37 129.7 11.7 2.3 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase zf-Tim10_DDP PF02953.15 AAS52076.1 - 2.8e-20 71.7 2.4 3.6e-20 71.4 2.4 1.1 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tom5 PF10642.9 AAS52076.1 - 0.11 12.5 0.3 0.18 11.9 0.3 1.3 1 0 0 1 1 1 0 Mitochondrial import receptor subunit or translocase Flavoprotein PF02441.19 AAS52077.1 - 6e-53 178.8 0.0 8.6e-53 178.3 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein DUF2457 PF10446.9 AAS52077.1 - 0.25 10.5 11.6 0.38 9.9 11.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 AAS52077.1 - 9.1 5.6 11.3 14 5.0 11.3 1.2 1 0 0 1 1 1 0 SDA1 Ydc2-catalyt PF09159.10 AAS52078.2 - 5.1e-26 92.0 0.0 2.5e-24 86.5 0.0 2.6 1 1 0 1 1 1 1 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Peptidase_S24 PF00717.23 AAS52079.1 - 4.6e-08 32.9 0.1 7.3e-08 32.3 0.1 1.4 1 0 0 1 1 1 1 Peptidase S24-like FF PF01846.19 AAS52080.1 - 1.6e-39 133.9 19.6 6.6e-15 55.0 0.1 5.9 5 0 0 5 5 5 4 FF domain WW PF00397.26 AAS52080.1 - 6.5e-18 64.5 13.2 4.5e-10 39.4 2.8 2.6 2 0 0 2 2 2 2 WW domain PQQ PF01011.21 AAS52080.1 - 0.0016 18.3 0.1 0.0079 16.1 0.0 2.0 2 0 0 2 2 2 1 PQQ enzyme repeat Glyco_hyd_101C PF17451.2 AAS52080.1 - 0.05 13.9 4.9 2 8.7 0.3 2.9 1 1 1 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain PQQ_2 PF13360.6 AAS52080.1 - 0.071 12.7 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 PQQ-like domain RRF PF01765.19 AAS52080.1 - 2.6 8.0 7.1 0.4 10.6 1.8 2.3 2 1 0 2 2 2 0 Ribosome recycling factor Sod_Fe_C PF02777.18 AAS52081.2 - 3.1e-34 117.2 0.1 6.1e-34 116.2 0.1 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AAS52081.2 - 5.6e-27 94.0 0.5 9.4e-27 93.3 0.5 1.4 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain p450 PF00067.22 AAS52083.1 - 3.1e-99 332.8 0.0 3.6e-99 332.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Pkinase PF00069.25 AAS52084.1 - 6.8e-43 146.9 0.0 2.1e-36 125.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52084.1 - 6.3e-21 74.8 0.0 8e-18 64.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AAS52084.1 - 1.3e-06 27.9 0.0 1.2e-05 24.8 0.0 2.1 1 1 0 1 1 1 1 Kinase-like FTA2 PF13095.6 AAS52084.1 - 7.5e-05 22.5 0.1 0.026 14.2 0.0 2.2 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 AAS52084.1 - 0.14 11.1 0.8 0.21 10.5 0.8 1.3 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 AAS52084.1 - 0.14 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 AAS52084.1 - 0.15 11.4 0.6 0.22 10.8 0.6 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family AAA_18 PF13238.6 AAS52085.1 - 9.3e-10 39.1 0.0 1.6e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain SKI PF01202.22 AAS52085.1 - 1.1e-09 38.6 0.0 1.2e-09 38.5 0.0 1.1 1 0 0 1 1 1 1 Shikimate kinase AAA_33 PF13671.6 AAS52085.1 - 2e-06 28.0 0.0 2.7e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AAS52085.1 - 2.6e-05 24.7 0.0 4.3e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 AAS52085.1 - 6.5e-05 22.9 0.0 8.4e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Adenylylsulphate kinase CPT PF07931.12 AAS52085.1 - 8.7e-05 22.4 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_22 PF13401.6 AAS52085.1 - 0.00043 20.6 0.7 0.0045 17.3 0.7 2.2 1 1 0 1 1 1 1 AAA domain dNK PF01712.19 AAS52085.1 - 0.0066 16.3 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 1 Deoxynucleoside kinase Cytidylate_kin PF02224.18 AAS52085.1 - 0.0082 15.9 0.0 0.019 14.7 0.0 1.6 1 1 0 1 1 1 1 Cytidylate kinase AAA PF00004.29 AAS52085.1 - 0.0093 16.4 0.0 0.015 15.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 AAS52085.1 - 0.017 14.4 0.2 0.032 13.5 0.2 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 AAS52085.1 - 0.017 15.5 0.3 0.036 14.5 0.3 1.7 1 1 0 1 1 1 0 AAA ATPase domain Cytidylate_kin2 PF13189.6 AAS52085.1 - 0.02 15.0 0.2 0.058 13.5 0.1 1.7 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_30 PF13604.6 AAS52085.1 - 0.028 14.1 0.4 0.06 13.1 0.4 1.5 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AAS52085.1 - 0.03 14.6 1.6 0.043 14.1 0.9 1.7 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 AAS52085.1 - 0.038 13.2 0.1 0.055 12.7 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CoaE PF01121.20 AAS52085.1 - 0.053 13.2 0.6 0.45 10.2 0.1 2.1 2 0 0 2 2 2 0 Dephospho-CoA kinase T2SSE PF00437.20 AAS52085.1 - 0.14 11.2 0.9 0.33 10.0 0.5 1.7 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 AAS52085.1 - 0.18 11.6 0.1 0.3 10.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain CbiA PF01656.23 AAS52085.1 - 0.84 9.7 3.7 1.3 9.0 3.0 1.6 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Thiolase_N PF00108.23 AAS52086.1 - 1.8e-97 325.7 6.9 2.5e-97 325.3 6.9 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AAS52086.1 - 1.1e-44 151.0 0.3 1.1e-44 151.0 0.3 2.2 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AAS52086.1 - 2.3e-06 27.4 2.7 5.9e-06 26.0 2.7 1.7 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 AAS52086.1 - 0.011 15.6 0.2 0.1 12.4 0.4 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Trm112p PF03966.16 AAS52087.1 - 3.3e-20 72.4 0.0 4.1e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Trm112p-like protein T4-gp15_tss PF16724.5 AAS52087.1 - 0.11 12.3 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 T4-like virus Myoviridae tail sheath stabiliser Pkinase PF00069.25 AAS52088.2 - 4.2e-78 262.3 0.0 6.1e-78 261.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52088.2 - 1.2e-31 109.9 0.0 4.7e-30 104.7 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52088.2 - 1.4e-06 27.9 0.1 0.00038 19.9 0.0 2.4 1 1 1 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AAS52088.2 - 0.0012 17.7 0.0 0.0026 16.6 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AAS52088.2 - 0.038 13.3 0.0 0.063 12.6 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS52088.2 - 0.1 12.5 0.0 3.2 7.6 0.0 2.3 1 1 1 2 2 2 0 Phosphotransferase enzyme family MutS_V PF00488.21 AAS52089.1 - 1.5e-65 220.8 0.2 1.1e-64 217.9 0.0 2.3 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 AAS52089.1 - 7.5e-32 111.1 0.8 7.5e-32 111.1 0.8 2.1 2 0 0 2 2 2 1 MutS domain III MutS_I PF01624.20 AAS52089.1 - 2.5e-30 105.0 0.5 6.4e-30 103.7 0.5 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 AAS52089.1 - 3.8e-07 30.5 0.0 8.8e-06 26.0 0.0 3.1 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 AAS52089.1 - 0.0012 19.2 0.0 0.004 17.5 0.0 2.0 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 AAS52089.1 - 0.021 14.9 0.2 0.32 11.0 0.0 2.8 2 1 0 2 2 2 0 AAA domain Rad17 PF03215.15 AAS52089.1 - 0.026 14.5 0.0 0.11 12.4 0.0 2.0 1 1 0 1 1 1 0 Rad17 P-loop domain UQ_con PF00179.26 AAS52090.1 - 2e-43 147.4 0.0 2.4e-43 147.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UBA_3 PF09288.10 AAS52090.1 - 5.3e-28 96.6 1.7 8.3e-28 96.0 1.7 1.3 1 0 0 1 1 1 1 Fungal ubiquitin-associated domain UBA PF00627.31 AAS52090.1 - 0.001 18.9 1.0 0.002 18.0 0.1 1.9 2 0 0 2 2 2 1 UBA/TS-N domain Calsarcin PF05556.11 AAS52090.1 - 0.011 15.3 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Prok-E2_B PF14461.6 AAS52090.1 - 0.035 13.8 0.0 0.053 13.2 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family B RGS12_usC PF16612.5 AAS52090.1 - 0.11 12.9 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal unstructured region of RGS12 GGA_N-GAT PF18308.1 AAS52090.1 - 1.9 8.2 5.1 3.1 7.5 0.3 2.8 2 1 0 2 2 2 0 GGA N-GAT domain CDC50 PF03381.15 AAS52091.1 - 3.8e-91 305.5 0.0 4.5e-91 305.2 0.0 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family CBF PF03914.17 AAS52092.2 - 4.1e-36 124.6 2.2 4.9e-36 124.3 0.3 2.0 2 1 0 2 2 2 1 CBF/Mak21 family RasGEF_N PF00618.20 AAS52092.2 - 0.24 11.6 2.1 7.6 6.8 0.0 3.0 3 1 0 3 3 3 0 RasGEF N-terminal motif Arrestin_C PF02752.22 AAS52093.1 - 1.4e-23 83.8 0.0 4.7e-23 82.1 0.0 1.9 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AAS52093.1 - 3.2e-06 27.3 0.0 1.7e-05 24.9 0.0 2.1 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain LDB19 PF13002.7 AAS52093.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Arrestin_N terminal like Pkinase PF00069.25 AAS52095.1 - 2.7e-46 158.1 0.1 1e-43 149.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52095.1 - 5e-21 75.1 0.0 2.7e-20 72.8 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52095.1 - 0.027 13.8 0.0 0.054 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 AAS52095.1 - 0.041 13.8 0.1 0.47 10.3 0.0 2.5 2 1 1 3 3 3 0 Phosphotransferase enzyme family WD40 PF00400.32 AAS52096.1 - 1.4e-20 73.2 20.1 4.3e-05 24.2 1.5 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 AAS52096.1 - 0.0024 16.6 3.4 0.49 9.0 0.3 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 V_ATPase_I PF01496.19 AAS52097.2 - 1.7e-301 1002.1 0.1 1.9e-301 1001.9 0.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family HlyE PF06109.13 AAS52097.2 - 0.58 9.4 3.6 9.5 5.4 0.2 2.7 3 0 0 3 3 3 0 Haemolysin E (HlyE) LCM PF04072.14 AAS52098.2 - 2.3e-24 86.4 0.0 3e-24 86.0 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase TAFII28 PF04719.14 AAS52099.1 - 3.6e-25 87.9 0.4 5.9e-22 77.6 0.1 2.6 2 0 0 2 2 2 2 hTAFII28-like protein conserved region PGA2 PF07543.12 AAS52099.1 - 0.49 10.4 4.7 0.34 10.9 1.2 2.1 2 0 0 2 2 2 0 Protein trafficking PGA2 PIG-S PF10510.9 AAS52100.1 - 5.6e-130 434.6 6.0 6.5e-130 434.4 6.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein Methyltransf_11 PF08241.12 AAS52101.2 - 2.7e-11 43.9 0.0 4.5e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS52101.2 - 7.9e-10 39.3 0.0 1.4e-09 38.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS52101.2 - 8.1e-06 25.8 0.1 1.6e-05 24.8 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS52101.2 - 8.9e-06 25.6 0.0 1.4e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS52101.2 - 2.5e-05 25.0 0.0 4.6e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UBA_4 PF14555.6 AAS52102.1 - 2.3e-12 46.5 0.0 4.9e-12 45.5 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 AAS52102.1 - 3.1e-10 40.1 0.0 7.8e-08 32.4 0.0 3.2 4 1 0 4 4 4 1 UBX domain Cnd1_N PF12922.7 AAS52102.1 - 0.13 12.1 2.4 0.12 12.2 0.8 1.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term TALPID3 PF15324.6 AAS52102.1 - 0.19 9.4 5.1 0.25 9.0 5.1 1.1 1 0 0 1 1 1 0 Hedgehog signalling target LRS4 PF10422.9 AAS52102.1 - 2 7.9 8.7 2.6 7.5 7.9 1.5 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 RRM_1 PF00076.22 AAS52103.1 - 1.3e-28 98.6 0.1 1.9e-16 59.7 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AAS52103.1 - 0.0091 15.6 0.0 0.029 14.0 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 AAS52103.1 - 0.013 15.6 0.0 7 6.8 0.0 2.2 2 0 0 2 2 2 0 Limkain b1 RRM_occluded PF16842.5 AAS52103.1 - 0.022 14.6 0.0 0.59 10.0 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif RNA_bind PF08675.11 AAS52103.1 - 0.25 11.4 0.0 0.38 10.8 0.0 1.2 1 0 0 1 1 1 0 RNA binding domain M16C_assoc PF08367.11 AAS52104.2 - 1.4e-63 214.4 0.6 2e-63 213.9 0.6 1.3 1 0 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 AAS52104.2 - 7e-32 110.9 0.2 6.8e-22 78.4 0.0 3.4 4 0 0 4 4 4 2 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AAS52104.2 - 2.6e-08 34.0 0.0 4.6e-07 29.9 0.0 2.4 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) EMP24_GP25L PF01105.24 AAS52105.1 - 8.2e-39 133.4 0.1 9.8e-39 133.2 0.1 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Rad33 PF08730.10 AAS52106.1 - 2.8e-15 56.7 0.0 7.4e-07 29.3 0.0 2.1 1 1 1 2 2 2 2 Rad33 Spt5-NGN PF03439.13 AAS52107.2 - 1.4e-21 76.1 0.0 2.9e-21 75.1 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section Spt5_N PF11942.8 AAS52107.2 - 4.4e-20 72.5 16.4 4.4e-20 72.5 16.4 2.6 2 0 0 2 2 2 1 Spt5 transcription elongation factor, acidic N-terminal KOW PF00467.29 AAS52107.2 - 9.2e-13 47.7 7.1 0.015 15.2 0.2 4.8 4 0 0 4 4 4 3 KOW motif CTD PF12815.7 AAS52107.2 - 0.00079 19.9 28.5 0.00079 19.9 28.5 3.4 1 1 2 3 3 3 1 Spt5 C-terminal nonapeptide repeat binding Spt4 DUF3912 PF13051.6 AAS52107.2 - 0.024 14.9 0.6 2.3 8.5 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3912) SPT6_acidic PF14632.6 AAS52107.2 - 6.3 7.5 46.9 0.059 14.0 22.6 2.6 1 1 1 2 2 2 0 Acidic N-terminal SPT6 PPV_E1_N PF00524.18 AAS52107.2 - 8.7 6.8 17.6 0.14 12.6 9.2 2.3 2 1 1 3 3 3 0 E1 Protein, N terminal domain BUD22 PF09073.10 AAS52107.2 - 8.9 5.5 29.6 15 4.7 29.6 1.3 1 0 0 1 1 1 0 BUD22 Ribosomal_L33 PF00471.20 AAS52108.1 - 0.026 14.9 0.1 0.081 13.4 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L33 eIF3g PF12353.8 AAS52109.1 - 1.5e-38 132.0 0.2 2.3e-38 131.4 0.2 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 AAS52109.1 - 5.8e-12 45.3 0.0 9.5e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_2 PF13696.6 AAS52109.1 - 0.00099 18.9 1.2 0.0016 18.2 1.2 1.2 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 AAS52109.1 - 0.0087 16.1 0.8 0.014 15.5 0.8 1.3 1 0 0 1 1 1 1 Zinc knuckle Nup35_RRM_2 PF14605.6 AAS52109.1 - 0.014 15.4 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-Mss51 PF13824.6 AAS52109.1 - 1 9.5 3.2 0.75 9.9 0.4 2.1 3 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Abhydrolase_3 PF07859.13 AAS52110.1 - 4.6e-09 36.4 0.0 5.5e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 AAS52110.1 - 0.00015 20.8 0.0 0.00023 20.2 0.0 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Abhydrolase_6 PF12697.7 AAS52110.1 - 0.00038 21.1 0.3 0.00043 20.9 0.3 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AAS52110.1 - 0.0022 17.7 0.0 0.0088 15.7 0.0 1.8 1 1 1 2 2 2 1 alpha/beta hydrolase fold LIDHydrolase PF10230.9 AAS52110.1 - 0.011 15.3 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 AAS52110.1 - 0.018 14.4 0.0 0.054 12.7 0.0 1.8 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF900 PF05990.12 AAS52110.1 - 0.068 12.7 0.0 0.1 12.1 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Rpn9_C PF18261.1 AAS52111.1 - 1e-17 63.4 2.8 2.3e-17 62.2 2.8 1.7 1 0 0 1 1 1 1 Rpn9 C-terminal helix PCI PF01399.27 AAS52111.1 - 6.2e-10 39.5 0.0 3.2e-09 37.2 0.0 2.2 2 0 0 2 2 2 1 PCI domain PX PF00787.24 AAS52112.1 - 8e-16 58.0 2.4 2.5e-15 56.4 0.1 2.6 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 AAS52112.1 - 0.095 12.2 5.1 0.026 14.1 1.2 2.0 2 0 0 2 2 2 0 Vps5 C terminal like FtsX_ECD PF18075.1 AAS52112.1 - 0.23 12.1 1.2 0.56 10.9 0.1 2.2 2 1 0 2 2 2 0 FtsX extracellular domain FliJ PF02050.16 AAS52112.1 - 4.3 7.6 11.1 1.9 8.7 4.7 3.0 3 0 0 3 3 3 0 Flagellar FliJ protein Dynein_light PF01221.18 AAS52113.1 - 2e-33 114.5 0.0 2.2e-33 114.4 0.0 1.0 1 0 0 1 1 1 1 Dynein light chain type 1 PipA PF07108.11 AAS52113.1 - 0.044 13.3 0.0 0.052 13.1 0.0 1.0 1 0 0 1 1 1 0 PipA protein AMPKBI PF04739.15 AAS52114.2 - 1.3e-20 73.4 0.2 4e-20 71.9 0.2 1.8 1 0 0 1 1 1 1 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM PF16561.5 AAS52114.2 - 5.5e-08 32.9 0.0 1.7e-07 31.4 0.0 1.8 2 0 0 2 2 2 1 Glycogen recognition site of AMP-activated protein kinase MutS_II PF05188.17 AAS52114.2 - 0.13 12.6 0.5 0.31 11.3 0.5 1.7 1 0 0 1 1 1 0 MutS domain II bZIP_1 PF00170.21 AAS52115.2 - 3.4e-06 27.1 10.3 5.1e-06 26.5 10.3 1.3 1 0 0 1 1 1 1 bZIP transcription factor ERM PF00769.19 AAS52115.2 - 1.9e-05 24.6 0.1 2.3e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family bZIP_2 PF07716.15 AAS52115.2 - 4.6e-05 23.4 11.9 7.5e-05 22.7 11.9 1.3 1 0 0 1 1 1 1 Basic region leucine zipper SHE3 PF17078.5 AAS52115.2 - 0.045 13.5 1.6 0.069 12.9 1.6 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 AAS52115.2 - 0.11 13.0 9.9 0.19 12.2 9.9 1.4 1 0 0 1 1 1 0 bZIP Maf transcription factor LCD1 PF09798.9 AAS52115.2 - 0.34 9.4 0.9 0.44 9.0 0.9 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Macoilin PF09726.9 AAS52115.2 - 0.43 9.1 2.2 0.55 8.7 2.2 1.1 1 0 0 1 1 1 0 Macoilin family Sterol_MT_C PF08498.10 AAS52116.1 - 2.9e-26 91.5 0.6 4.6e-26 90.9 0.6 1.3 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 AAS52116.1 - 6.6e-20 71.6 0.0 1.2e-19 70.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS52116.1 - 2.6e-16 60.1 0.0 4.8e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS52116.1 - 1.6e-14 53.9 0.0 2.5e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AAS52116.1 - 2.5e-11 43.4 0.1 3.4e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.6 AAS52116.1 - 2.6e-10 40.4 0.0 4.6e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AAS52116.1 - 1.2e-09 37.9 0.0 1.7e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AAS52116.1 - 2.1e-08 34.8 0.0 4.6e-08 33.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 AAS52116.1 - 0.00078 19.0 0.1 0.0013 18.4 0.1 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_2 PF00891.18 AAS52116.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase domain PCMT PF01135.19 AAS52116.1 - 0.042 13.6 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Sugar_tr PF00083.24 AAS52117.2 - 2.5e-29 102.4 22.0 5.2e-19 68.4 4.9 2.0 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 AAS52117.2 - 1.6e-16 60.2 41.3 4.3e-10 39.0 18.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF5391 PF17369.2 AAS52117.2 - 0.13 12.3 2.3 0.46 10.5 1.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5391) BatA PF07584.11 AAS52117.2 - 1.1 9.6 3.6 15 6.0 0.6 3.1 2 1 0 2 2 2 0 Aerotolerance regulator N-terminal Zn_clus PF00172.18 AAS52119.2 - 1.8e-06 27.9 10.0 1.8e-06 27.9 10.0 1.8 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2340 PF10209.9 AAS52121.1 - 2.4e-46 157.1 0.0 2.8e-46 156.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2340) DUF676 PF05057.14 AAS52122.1 - 9.5e-44 149.5 0.0 1.2e-43 149.1 0.0 1.1 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Abhydrolase_6 PF12697.7 AAS52122.1 - 9.4e-05 23.1 0.1 9.4e-05 23.1 0.1 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Palm_thioest PF02089.15 AAS52122.1 - 0.00047 20.1 0.0 0.0007 19.5 0.0 1.2 1 0 0 1 1 1 1 Palmitoyl protein thioesterase TMEM191C PF15194.6 AAS52122.1 - 0.0081 16.3 0.6 0.017 15.3 0.6 1.5 1 0 0 1 1 1 1 TMEM191C family Abhydrolase_1 PF00561.20 AAS52122.1 - 0.0089 15.7 0.2 0.055 13.1 0.2 2.2 3 0 0 3 3 3 1 alpha/beta hydrolase fold PGAP1 PF07819.13 AAS52122.1 - 0.018 14.7 0.0 0.034 13.8 0.0 1.5 1 1 0 1 1 1 0 PGAP1-like protein Sld7_N PF18636.1 AAS52123.2 - 1.7e-28 99.4 0.0 2.3e-28 99.0 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sld7_C PF18596.1 AAS52123.2 - 2.5e-17 62.8 0.0 4.3e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 Sld7 C-terminal domain Pkinase PF00069.25 AAS52124.1 - 6.5e-58 196.2 0.0 7.7e-58 195.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52124.1 - 1.4e-15 57.3 0.0 2.1e-15 56.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AAS52124.1 - 5.1e-07 29.9 0.2 1e-06 28.9 0.2 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 AAS52124.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 AAS52124.1 - 0.042 12.6 0.0 0.063 12.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 AAS52124.1 - 0.048 13.0 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L3 PF00297.22 AAS52126.2 - 4.5e-192 637.9 10.2 5.1e-192 637.8 10.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Tho1_MOS11_C PF18592.1 AAS52126.2 - 0.35 10.7 2.2 1.9 8.3 0.3 2.9 3 0 0 3 3 3 0 Tho1/MOS11 C-terminal domain PHD PF00628.29 AAS52127.1 - 4e-05 23.4 5.6 6.3e-05 22.8 5.6 1.3 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AAS52127.1 - 0.079 13.2 2.2 0.13 12.5 2.2 1.4 1 0 0 1 1 1 0 PHD-like zinc-binding domain Phage_cap_E PF03864.15 AAS52127.1 - 0.24 10.6 0.3 0.36 9.9 0.3 1.2 1 0 0 1 1 1 0 Phage major capsid protein E Cytochrom_C1 PF02167.15 AAS52128.2 - 3e-96 321.4 0.0 3.7e-96 321.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 AAS52128.2 - 0.00061 20.1 0.0 0.0014 19.0 0.0 1.6 1 0 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 AAS52128.2 - 0.002 19.2 0.1 0.0045 18.1 0.1 1.9 1 1 0 1 1 1 1 Cytochrome c FlhD PF05247.13 AAS52129.2 - 0.12 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhD) DUF4680 PF15730.5 AAS52129.2 - 1.9 8.8 9.0 0.061 13.7 0.9 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4680) Alg6_Alg8 PF03155.15 AAS52130.2 - 1.5e-162 541.9 30.8 1.8e-162 541.7 30.8 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Vps5 PF09325.10 AAS52131.1 - 7.6e-86 287.5 10.2 1.3e-85 286.8 10.2 1.4 1 0 0 1 1 1 1 Vps5 C terminal like PX PF00787.24 AAS52131.1 - 3.3e-24 85.1 0.8 8.4e-24 83.7 0.1 2.0 2 0 0 2 2 2 1 PX domain BAR_3_WASP_bdg PF10456.9 AAS52131.1 - 0.15 11.5 1.9 0.33 10.4 1.9 1.6 1 1 0 1 1 1 0 WASP-binding domain of Sorting nexin protein Tup_N PF08581.10 AAS52131.1 - 0.16 12.3 0.2 0.16 12.3 0.2 2.5 2 0 0 2 2 2 0 Tup N-terminal FlaC_arch PF05377.11 AAS52131.1 - 0.32 11.4 2.3 40 4.7 2.0 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Tropomyosin PF00261.20 AAS52131.1 - 1.2 8.4 9.4 0.27 10.6 2.1 2.3 2 0 0 2 2 2 0 Tropomyosin Fib_alpha PF08702.10 AAS52131.1 - 1.8 8.8 9.4 0.083 13.1 0.5 2.5 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TACC_C PF05010.14 AAS52131.1 - 2.2 8.0 10.8 2.5 7.9 2.0 2.5 1 1 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Sec34 PF04136.15 AAS52131.1 - 3.5 7.5 8.6 1.2 9.0 2.1 2.5 1 1 0 2 2 2 0 Sec34-like family Lactamase_B_4 PF13691.6 AAS52132.2 - 1.2e-22 79.3 0.0 2.4e-22 78.4 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease Lactamase_B_2 PF12706.7 AAS52132.2 - 2.5e-14 53.3 0.0 5.3e-06 26.1 0.0 3.3 4 0 0 4 4 4 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AAS52132.2 - 0.076 13.0 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily RabGAP-TBC PF00566.18 AAS52133.2 - 1.5e-50 171.8 1.7 1.5e-50 171.8 1.7 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain IL34 PF15036.6 AAS52133.2 - 0.063 13.3 0.0 0.2 11.7 0.0 1.8 1 0 0 1 1 1 0 Interleukin 34 THF_DHG_CYH PF00763.23 AAS52134.1 - 1.6e-24 86.4 0.0 4.5e-24 85.0 0.0 1.8 3 0 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH_C PF02882.19 AAS52134.1 - 3.3e-17 62.2 0.0 1e-10 41.1 0.0 2.7 2 1 0 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain FTP PF07504.13 AAS52134.1 - 0.1 12.4 0.9 0.24 11.2 0.9 1.6 1 0 0 1 1 1 0 Fungalysin/Thermolysin Propeptide Motif Brix PF04427.18 AAS52135.1 - 9.1e-36 123.8 0.1 1.3e-35 123.3 0.1 1.2 1 0 0 1 1 1 1 Brix domain Nucleoporin_N PF08801.11 AAS52136.2 - 1.1e-65 222.1 0.1 1.5e-65 221.6 0.1 1.2 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 AAS52136.2 - 3.5e-29 102.0 3.5 6.2e-29 101.2 3.5 1.3 1 0 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal Nup160 PF11715.8 AAS52136.2 - 2.2e-05 23.4 0.0 3.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 FapA PF03961.13 AAS52136.2 - 0.032 12.8 0.2 0.053 12.1 0.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TraG-D_C PF12696.7 AAS52136.2 - 0.09 12.8 0.0 0.27 11.2 0.0 1.8 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG DASH_Dad2 PF08654.10 AAS52137.1 - 3e-29 101.4 0.1 3.3e-29 101.2 0.1 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad2 Rogdi_lz PF10259.9 AAS52137.1 - 0.0045 16.5 0.2 0.0053 16.3 0.2 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein DASH_Duo1 PF08651.10 AAS52137.1 - 0.0058 16.4 1.1 0.0078 16.0 1.1 1.2 1 0 0 1 1 1 1 DASH complex subunit Duo1 FlaC_arch PF05377.11 AAS52137.1 - 0.044 14.2 0.1 0.073 13.5 0.1 1.4 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) COG5 PF10392.9 AAS52137.1 - 0.05 13.8 0.6 0.066 13.4 0.6 1.2 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Shugoshin_N PF07558.11 AAS52138.2 - 2.8e-17 62.3 4.2 2.8e-17 62.3 4.2 1.8 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region Shugoshin_C PF07557.11 AAS52138.2 - 6.2e-11 41.9 4.3 6.2e-11 41.9 4.3 3.1 4 0 0 4 4 4 1 Shugoshin C terminus TSC22 PF01166.18 AAS52138.2 - 0.01 16.1 0.8 0.028 14.7 0.6 1.9 1 1 0 1 1 1 0 TSC-22/dip/bun family GIT_CC PF16559.5 AAS52138.2 - 0.13 12.2 4.5 0.44 10.4 4.5 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CHZ PF09649.10 AAS52138.2 - 0.16 11.5 0.7 0.44 10.1 0.7 1.7 1 0 0 1 1 1 0 Histone chaperone domain CHZ Thymidylat_synt PF00303.19 AAS52139.1 - 4.2e-113 376.9 0.0 5.1e-113 376.6 0.0 1.1 1 0 0 1 1 1 1 Thymidylate synthase Syntaxin-18_N PF10496.9 AAS52140.2 - 3.1e-18 65.8 0.7 8.3e-18 64.4 0.0 2.1 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus SNARE PF05739.19 AAS52140.2 - 0.00052 19.9 0.1 0.0071 16.3 0.0 2.7 3 0 0 3 3 3 1 SNARE domain HMMR_C PF15908.5 AAS52140.2 - 0.068 13.4 6.5 0.16 12.2 6.5 1.6 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal SecE PF00584.20 AAS52140.2 - 0.08 12.9 0.3 0.24 11.4 0.1 1.9 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex MAT1 PF06391.13 AAS52140.2 - 8.2 6.2 17.0 0.16 11.8 9.5 1.9 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 GTP_EFTU PF00009.27 AAS52141.2 - 2.3e-42 144.8 0.0 3.7e-42 144.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain HBS1_N PF08938.10 AAS52141.2 - 8.3e-13 48.4 6.0 2e-12 47.2 6.0 1.6 1 0 0 1 1 1 1 HBS1 N-terminus GTP_EFTU_D3 PF03143.17 AAS52141.2 - 2e-08 34.5 0.0 3.7e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 AAS52141.2 - 4.3e-06 26.8 0.0 0.00012 22.2 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 AAS52141.2 - 0.09 13.0 0.1 14 5.9 0.0 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS52141.2 - 0.092 12.2 0.0 12 5.2 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family FeoB_N PF02421.18 AAS52141.2 - 0.12 11.8 0.1 1.9 8.0 0.1 2.7 2 1 0 2 2 2 0 Ferrous iron transport protein B GTP_EFTU_D2 PF03144.25 AAS52141.2 - 0.13 12.7 0.1 0.3 11.5 0.1 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 2 IQ_SEC7_PH PF16453.5 AAS52142.1 - 0.057 13.4 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 PH domain Scm3 PF10384.9 AAS52142.1 - 0.5 10.2 2.9 4.2 7.2 0.2 2.2 2 0 0 2 2 2 0 Centromere protein Scm3 MRP-L20 PF12824.7 AAS52143.1 - 1.7e-50 171.4 1.6 2e-50 171.2 1.6 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein subunit L20 Integrase_Zn PF02022.19 AAS52143.1 - 0.073 13.1 0.1 18 5.4 0.0 2.6 2 1 0 2 2 2 0 Integrase Zinc binding domain HA2 PF04408.23 AAS52144.1 - 1.1e-22 80.4 0.6 5.3e-22 78.2 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 AAS52144.1 - 3.4e-16 59.4 0.0 1.1e-15 57.7 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 AAS52144.1 - 5.3e-13 49.3 0.1 1.4e-12 47.9 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AAS52144.1 - 1.8e-06 28.2 0.1 5.6e-06 26.7 0.1 1.8 1 0 0 1 1 1 1 AAA domain DEAD PF00270.29 AAS52144.1 - 0.00016 21.5 0.1 0.00034 20.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 AAS52144.1 - 0.0026 18.1 0.1 0.0072 16.7 0.1 1.7 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 AAS52144.1 - 0.0038 16.5 0.1 0.27 10.4 0.0 2.3 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 AAS52144.1 - 0.0069 16.6 0.1 0.035 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_23 PF13476.6 AAS52144.1 - 0.0071 16.9 0.5 0.061 13.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS52144.1 - 0.0096 15.7 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 AAS52144.1 - 0.019 15.0 0.0 0.041 13.9 0.0 1.6 1 0 0 1 1 1 0 Flavivirus DEAD domain T2SSE PF00437.20 AAS52144.1 - 0.025 13.6 0.1 0.062 12.3 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 AAS52144.1 - 0.037 14.1 0.5 0.51 10.4 0.5 2.5 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 AAS52144.1 - 0.04 13.6 0.1 5.9 6.6 0.0 2.4 1 1 1 2 2 2 0 IstB-like ATP binding protein PhoH PF02562.16 AAS52144.1 - 0.049 13.1 0.0 0.12 11.8 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 AAS52144.1 - 0.069 13.7 0.0 0.37 11.3 0.0 2.3 2 0 0 2 2 1 0 ABC transporter AAA_29 PF13555.6 AAS52144.1 - 0.083 12.6 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DAP3 PF10236.9 AAS52144.1 - 0.1 11.7 0.3 2.5 7.2 0.0 2.8 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 DUF1509 PF07420.11 AAS52144.1 - 0.31 10.0 4.9 0.12 11.3 1.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1509) Kin17_mid PF10357.9 AAS52145.1 - 8.4e-45 151.8 6.9 1.4e-44 151.1 6.9 1.3 1 0 0 1 1 1 1 Domain of Kin17 curved DNA-binding protein zf-C2H2_jaz PF12171.8 AAS52145.1 - 4.1e-07 30.1 2.6 1.2e-06 28.6 2.6 1.9 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AAS52145.1 - 5.2e-05 23.5 2.1 5.2e-05 23.5 2.1 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AAS52145.1 - 0.0098 16.2 0.2 0.0098 16.2 0.2 2.5 2 1 1 3 3 3 1 C2H2 type zinc-finger (2 copies) TFIID_NTD2 PF04494.15 AAS52145.1 - 0.018 15.3 1.5 0.018 15.3 1.5 2.0 2 1 0 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain zf-C2H2_4 PF13894.6 AAS52145.1 - 0.15 12.9 3.5 0.19 12.7 0.8 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger AKAP95 PF04988.12 AAS52145.1 - 1.2 9.3 10.7 0.053 13.8 4.5 1.9 3 0 0 3 3 3 0 A-kinase anchoring protein 95 (AKAP95) SNARE_assoc PF09335.11 AAS52146.1 - 2.9e-15 56.8 5.8 2.9e-15 56.8 5.8 2.6 2 1 1 3 3 3 1 SNARE associated Golgi protein Spore_YtrH PF14034.6 AAS52146.1 - 0.35 11.1 0.1 0.35 11.1 0.1 2.9 2 1 1 3 3 3 0 Sporulation protein YtrH DUF2207 PF09972.9 AAS52146.1 - 0.67 8.6 7.0 0.12 11.2 2.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) PHO4 PF01384.20 AAS52146.1 - 4.4 6.2 7.4 96 1.8 7.4 2.3 1 1 0 1 1 1 0 Phosphate transporter family U3_snoRNA_assoc PF08297.11 AAS52148.2 - 5.2e-19 68.7 4.9 5.2e-19 68.7 4.9 2.5 2 1 0 2 2 2 1 U3 snoRNA associated U79_P34 PF03064.16 AAS52148.2 - 0.1 12.0 5.7 0.18 11.1 5.7 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF3696 PF12476.8 AAS52148.2 - 0.1 13.0 0.1 0.2 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3696) Spem1 PF15670.5 AAS52148.2 - 0.58 9.7 4.6 0.78 9.3 4.1 1.4 1 1 0 1 1 1 0 Spermatid maturation protein 1 Zip PF02535.22 AAS52149.1 - 3.2e-22 79.2 16.6 3.1e-11 43.1 0.2 2.3 2 1 1 3 3 3 2 ZIP Zinc transporter TPR_1 PF00515.28 AAS52150.2 - 3.8e-08 32.8 5.9 0.00013 21.6 0.4 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat F-box PF00646.33 AAS52150.2 - 5.3e-08 32.5 1.7 0.00014 21.6 0.1 3.7 3 0 0 3 3 3 2 F-box domain TPR_2 PF07719.17 AAS52150.2 - 1.1e-07 31.4 7.9 0.00022 21.1 0.5 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat F-box-like PF12937.7 AAS52150.2 - 1.8e-05 24.5 5.4 1.8e-05 24.5 0.4 2.5 2 0 0 2 2 2 1 F-box-like TPR_12 PF13424.6 AAS52150.2 - 7.7e-05 22.9 4.4 0.023 15.0 0.4 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS52150.2 - 0.0005 19.9 5.3 0.18 11.9 0.2 3.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS52150.2 - 0.00061 20.4 0.1 0.17 12.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 AAS52150.2 - 0.00073 19.5 0.3 1.9 8.6 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS52150.2 - 0.0019 18.3 1.1 0.013 15.6 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 AAS52150.2 - 0.002 18.2 0.1 0.0061 16.7 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 AAS52150.2 - 0.01 15.5 2.2 0.088 12.5 0.6 2.5 2 0 0 2 2 2 0 TPR repeat TPR_16 PF13432.6 AAS52150.2 - 0.018 15.7 0.9 0.47 11.2 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat MIT PF04212.18 AAS52150.2 - 0.055 13.5 0.3 3.4 7.8 0.1 2.8 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 AAS52150.2 - 0.12 12.9 0.5 19 5.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 AAS52150.2 - 0.2 12.2 3.0 1.3 9.5 1.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat LRR_4 PF12799.7 AAS52150.2 - 0.22 12.0 11.3 0.26 11.8 0.1 4.8 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF3336 PF11815.8 AAS52151.2 - 6.6e-33 113.3 6.9 1.4e-32 112.3 6.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AAS52151.2 - 1.8e-23 83.8 0.0 3.2e-23 83.0 0.0 1.4 1 0 0 1 1 1 1 Patatin-like phospholipase LigA PF07746.11 AAS52151.2 - 0.14 12.3 1.1 0.83 9.9 0.6 2.5 2 0 0 2 2 2 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit LIM PF00412.22 AAS52152.1 - 7.6e-16 58.1 24.9 2.7e-09 37.1 9.4 2.4 2 0 0 2 2 2 2 LIM domain Whi5 PF08528.11 AAS52153.1 - 2.9e-11 42.7 0.4 5.2e-11 41.9 0.4 1.4 1 0 0 1 1 1 1 Whi5 like ANXA2R PF15721.5 AAS52153.1 - 0.049 14.2 5.2 0.1 13.1 5.2 1.6 1 0 0 1 1 1 0 Annexin-2 receptor DELLA PF12041.8 AAS52154.1 - 0.067 13.1 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal Rx_N PF18052.1 AAS52154.1 - 0.097 13.0 0.2 0.53 10.6 0.1 2.0 2 0 0 2 2 2 0 Rx N-terminal domain Cofilin_ADF PF00241.20 AAS52155.1 - 2.9e-40 136.8 0.1 3.2e-40 136.7 0.1 1.0 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein HTH_Tnp_Tc5 PF03221.16 AAS52156.1 - 3.1e-14 52.7 1.3 6.8e-14 51.6 0.1 2.1 2 0 0 2 2 2 1 Tc5 transposase DNA-binding domain DUF4817 PF16087.5 AAS52156.1 - 0.0022 17.8 0.1 0.0061 16.3 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain (DUF4817) HTH_32 PF13565.6 AAS52156.1 - 0.034 14.7 0.5 0.18 12.4 0.1 2.4 1 1 0 1 1 1 0 Homeodomain-like domain CENP-B_N PF04218.13 AAS52156.1 - 0.041 13.5 0.0 0.095 12.3 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Utp14 PF04615.13 AAS52156.1 - 0.043 12.4 2.0 0.063 11.9 2.0 1.1 1 0 0 1 1 1 0 Utp14 protein SET PF00856.28 AAS52157.2 - 2.3e-09 37.9 0.0 5.3e-09 36.7 0.0 1.6 1 0 0 1 1 1 1 SET domain Phosphoesterase PF04185.14 AAS52158.1 - 7.4e-38 130.7 3.6 2.7e-35 122.2 2.8 2.9 1 1 1 2 2 2 2 Phosphoesterase family Cu-oxidase_2 PF07731.14 AAS52159.2 - 8.5e-37 125.9 8.9 5.8e-34 116.8 0.6 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_3 PF07732.15 AAS52159.2 - 3.9e-36 123.7 2.6 1.9e-35 121.4 0.1 3.1 4 0 0 4 4 4 1 Multicopper oxidase Cu-oxidase PF00394.22 AAS52159.2 - 1.8e-31 109.4 0.4 6.1e-31 107.7 0.0 2.1 2 0 0 2 2 2 1 Multicopper oxidase COX6B PF02297.17 AAS52160.1 - 3.2e-21 75.4 3.4 3.5e-21 75.2 3.4 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb CX9C PF16860.5 AAS52160.1 - 0.026 14.5 1.5 0.041 13.9 1.5 1.3 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, RIC1 PF07064.13 AAS52161.1 - 5.1e-17 62.1 0.2 2.9e-16 59.7 0.2 2.2 2 1 0 2 2 2 1 RIC1 CAF1C_H4-bd PF12265.8 AAS52162.2 - 1.2e-14 54.3 0.1 3.8e-14 52.7 0.1 1.9 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AAS52162.2 - 7.9e-11 42.3 9.4 3.1e-05 24.6 0.2 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52162.2 - 6.7e-08 32.7 1.8 0.0011 19.2 0.2 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS52162.2 - 0.023 14.6 1.6 0.043 13.7 0.4 2.1 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AAS52162.2 - 0.046 12.4 1.2 5.3 5.6 0.0 2.2 2 0 0 2 2 2 0 Nucleoporin Nup120/160 TEX19 PF15553.6 AAS52162.2 - 1.8 8.5 5.4 1.6 8.7 0.9 2.5 2 0 0 2 2 2 0 Testis-expressed protein 19 NFACT-R_1 PF05670.13 AAS52163.1 - 2.8e-32 111.6 0.1 4.9e-32 110.8 0.1 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain NFACT-R_2 PF18297.1 AAS52163.1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 NFACT protein RNA binding domain Meiotic_rec114 PF03525.14 AAS52164.1 - 1.4e-09 37.4 0.6 6.8e-09 35.1 0.1 1.9 2 0 0 2 2 2 1 Meiotic recombination protein rec114 CLTH PF10607.9 AAS52168.1 - 6.1e-26 91.1 4.0 6.1e-26 91.1 4.0 2.2 1 1 1 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain GATA PF00320.27 AAS52169.1 - 3.8e-14 52.0 3.5 7.2e-14 51.1 3.5 1.5 1 0 0 1 1 1 1 GATA zinc finger DRMBL PF07522.14 AAS52170.1 - 5.9e-23 81.2 0.2 1.1e-22 80.3 0.2 1.5 1 0 0 1 1 1 1 DNA repair metallo-beta-lactamase Lactamase_B_2 PF12706.7 AAS52170.1 - 4.1e-06 26.4 0.1 8.7e-06 25.4 0.1 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AAS52170.1 - 0.13 12.2 0.7 0.35 10.8 0.2 1.8 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Arf PF00025.21 AAS52171.2 - 1.8e-45 154.5 0.0 2.1e-45 154.3 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AAS52171.2 - 1.1e-11 44.6 0.1 6.7e-07 28.8 0.0 2.7 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 AAS52171.2 - 9.3e-11 42.0 0.0 1.3e-10 41.6 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 AAS52171.2 - 1.6e-08 34.2 0.0 1.9e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 AAS52171.2 - 2.3e-07 30.6 0.0 2.8e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 AAS52171.2 - 3.3e-05 23.5 0.0 0.0019 17.8 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AAS52171.2 - 4.6e-05 22.9 0.0 6.2e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 AAS52171.2 - 4.7e-05 23.5 0.0 6.8e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 AAS52171.2 - 0.0048 16.5 0.0 0.088 12.4 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_16 PF13191.6 AAS52171.2 - 0.13 12.6 0.0 0.96 9.8 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain Ldh_1_N PF00056.23 AAS52172.2 - 2.7e-42 144.2 0.0 4.5e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AAS52172.2 - 1.4e-32 112.9 0.0 2.1e-32 112.4 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain 3Beta_HSD PF01073.19 AAS52172.2 - 0.00029 19.9 0.0 0.00044 19.3 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Pkinase PF00069.25 AAS52173.2 - 2.7e-62 210.5 0.0 3.4e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52173.2 - 2.2e-25 89.4 0.0 3.2e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AAS52173.2 - 0.013 15.4 0.1 0.03 14.3 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family RICTOR_M PF14666.6 AAS52173.2 - 0.032 14.0 0.2 0.07 12.9 0.2 1.6 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, middle domain Choline_kinase PF01633.20 AAS52173.2 - 0.056 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase TPP_enzyme_N PF02776.18 AAS52174.2 - 1.9e-28 99.2 0.1 3.6e-28 98.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS52174.2 - 7.9e-23 80.7 0.1 2.8e-22 78.9 0.0 1.8 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AAS52174.2 - 1.4e-16 60.7 0.0 2.5e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain zf-C3HC4_3 PF13920.6 AAS52175.2 - 0.25 11.2 6.7 0.73 9.7 4.3 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_60s PF00428.19 AAS52176.2 - 4.5e-24 84.8 9.0 5.6e-24 84.5 9.0 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L13e PF01294.18 AAS52177.2 - 4.5e-68 228.6 4.6 7.4e-68 227.9 4.6 1.3 1 0 0 1 1 1 1 Ribosomal protein L13e Ribosomal_S9 PF00380.19 AAS52178.1 - 1.4e-32 112.7 0.2 1.6e-32 112.5 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 DEAD PF00270.29 AAS52180.1 - 2.2e-35 122.0 0.0 3.7e-35 121.2 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52180.1 - 3.8e-27 94.8 0.2 4.3e-25 88.2 0.1 2.6 2 1 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52180.1 - 1.3e-08 35.0 0.0 2.6e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit RDM PF11002.8 AAS52181.2 - 0.0018 18.3 0.0 0.056 13.5 0.0 2.7 2 0 0 2 2 2 1 RFPL defining motif (RDM) HTH_psq PF05225.16 AAS52181.2 - 0.017 14.8 0.0 0.25 11.1 0.0 2.3 2 0 0 2 2 2 0 helix-turn-helix, Psq domain DUF455 PF04305.14 AAS52181.2 - 0.039 13.5 0.1 0.072 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF455) Pyr_redox_2 PF07992.14 AAS52182.1 - 7.2e-47 160.0 0.0 8.9e-47 159.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AAS52182.1 - 1.4e-11 44.7 0.0 3.2e-10 40.4 0.0 2.9 3 1 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AAS52182.1 - 0.0048 16.2 0.0 1.4 8.1 0.0 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase F-actin_cap_A PF01267.17 AAS52182.1 - 0.11 12.0 0.0 0.28 10.6 0.0 1.6 1 0 0 1 1 1 0 F-actin capping protein alpha subunit 4F5 PF04419.14 AAS52183.1 - 3.3e-09 37.5 9.6 3.3e-09 37.5 9.6 2.2 2 1 0 2 2 2 1 4F5 protein family Vac_Fusion PF02346.16 AAS52183.1 - 0.012 15.2 0.1 0.032 13.8 0.0 1.7 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 WD40 PF00400.32 AAS52184.1 - 8.8e-20 70.7 3.3 7e-06 26.7 0.2 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52184.1 - 1.1e-08 35.2 0.0 0.01 16.1 0.0 4.8 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS52184.1 - 0.0013 18.6 0.1 0.12 12.2 0.0 2.9 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A DLH PF01738.18 AAS52185.2 - 7.3e-21 74.7 0.0 8.1e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 AAS52185.2 - 0.0013 19.4 1.4 0.0016 19.1 1.4 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 AAS52185.2 - 0.0046 16.4 0.0 0.02 14.4 0.0 2.0 2 1 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 AAS52185.2 - 0.14 11.7 0.0 1.7 8.2 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) T5orf172 PF10544.9 AAS52186.2 - 2.8e-11 43.8 0.0 0.00013 22.4 0.0 2.4 1 1 1 2 2 2 2 T5orf172 domain MUG113 PF13455.6 AAS52186.2 - 5.5e-07 30.2 0.3 3.6e-06 27.6 0.3 2.2 1 1 0 1 1 1 1 Meiotically up-regulated gene 113 C_LFY_FLO PF17538.2 AAS52186.2 - 0.043 13.3 0.3 0.27 10.7 0.0 2.1 2 0 0 2 2 2 0 DNA Binding Domain (C-terminal) Leafy/Floricaula Osw5 PF17062.5 AAS52187.1 - 6.3e-21 74.2 8.4 8.5e-21 73.8 8.4 1.1 1 0 0 1 1 1 1 Outer spore wall 5 Ribophorin_II PF05817.14 AAS52188.1 - 2e-08 33.3 0.1 2.7e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II Peptidase_S24 PF00717.23 AAS52189.2 - 1.1e-05 25.3 0.1 3.7e-05 23.6 0.0 1.9 2 0 0 2 2 2 1 Peptidase S24-like Peptidase_S26 PF10502.9 AAS52189.2 - 9.2e-05 22.2 0.0 0.00016 21.5 0.0 1.4 1 1 0 1 1 1 1 Signal peptidase, peptidase S26 adh_short PF00106.25 AAS52190.2 - 7.6e-09 35.3 0.0 2.4e-06 27.1 0.0 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS52190.2 - 0.011 15.4 0.0 0.04 13.5 0.0 1.9 2 1 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase LUC7 PF03194.15 AAS52191.1 - 9.3e-54 182.7 10.8 1.1e-53 182.5 10.8 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Rho_Binding PF08912.11 AAS52191.1 - 0.011 16.5 2.3 0.53 11.1 0.2 3.1 3 0 0 3 3 3 0 Rho Binding DUF4200 PF13863.6 AAS52191.1 - 0.016 15.6 8.2 18 5.7 0.0 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) MukF_C PF17193.4 AAS52191.1 - 0.056 13.6 0.3 0.26 11.4 0.3 1.9 2 0 0 2 2 2 0 MukF C-terminal domain FlaC_arch PF05377.11 AAS52191.1 - 0.22 11.9 4.9 0.75 10.2 2.9 2.7 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) SlyX PF04102.12 AAS52191.1 - 6.7 7.4 11.2 3.2 8.4 0.1 3.2 3 1 1 4 4 4 0 SlyX Nup35_RRM PF05172.13 AAS52192.1 - 2.9e-33 113.9 0.0 5.7e-33 112.9 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Nup35_RRM_2 PF14605.6 AAS52192.1 - 0.0048 16.9 0.0 0.019 15.0 0.0 2.0 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Vmethyltransf PF01660.17 AAS52192.1 - 0.042 12.7 0.2 0.071 12.0 0.2 1.3 1 0 0 1 1 1 0 Viral methyltransferase RRM_1 PF00076.22 AAS52192.1 - 0.17 11.7 0.0 14 5.6 0.0 3.1 3 0 0 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2418 PF10332.9 AAS52193.2 - 8.7e-24 83.9 1.4 2.7e-23 82.3 1.4 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2418) FWWh PF14922.6 AAS52193.2 - 0.025 14.5 0.3 0.072 13.0 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function TTSSLRR PF12468.8 AAS52193.2 - 0.21 11.9 0.9 0.69 10.2 0.9 1.9 1 0 0 1 1 1 0 Type III secretion system leucine rich repeat protein Prenyltrans PF00432.21 AAS52195.1 - 3.8e-36 122.5 6.5 3.8e-13 48.9 2.8 4.5 4 0 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat UBX PF00789.20 AAS52196.2 - 3.1e-09 36.9 0.0 5.9e-09 36.0 0.0 1.4 1 0 0 1 1 1 1 UBX domain Anp1 PF03452.14 AAS52196.2 - 0.8 9.1 4.0 1.3 8.4 4.0 1.2 1 0 0 1 1 1 0 Anp1 SRP14 PF02290.15 AAS52197.2 - 6.4e-18 64.9 0.1 1.4e-17 63.8 0.1 1.6 1 1 0 1 1 1 1 Signal recognition particle 14kD protein Nodulin-like PF06813.13 AAS52198.2 - 9.3e-11 41.7 9.8 9.3e-11 41.7 9.8 3.1 4 0 0 4 4 4 1 Nodulin-like MFS_1 PF07690.16 AAS52198.2 - 1.2e-07 31.0 35.5 0.0003 19.8 19.4 2.2 1 1 0 2 2 2 2 Major Facilitator Superfamily PMT PF02366.18 AAS52199.2 - 4.7e-78 262.2 12.3 4.7e-78 262.2 12.3 2.0 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT_4TMC PF16192.5 AAS52199.2 - 4.9e-62 209.1 14.6 1.4e-61 207.6 14.6 1.8 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase MIR PF02815.19 AAS52199.2 - 2.3e-52 177.6 1.6 3.7e-52 176.9 1.6 1.3 1 0 0 1 1 1 1 MIR domain RPN6_N PF18055.1 AAS52200.1 - 3.2e-39 133.9 3.4 3.2e-39 133.9 3.4 2.9 3 1 0 3 3 3 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 AAS52200.1 - 1.6e-17 63.9 0.1 7.9e-17 61.7 0.0 2.2 2 0 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 AAS52200.1 - 1e-09 37.9 1.3 1.6e-09 37.3 0.3 1.9 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain TPR_12 PF13424.6 AAS52200.1 - 0.0023 18.2 0.5 0.0023 18.2 0.5 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Vps39_1 PF10366.9 AAS52200.1 - 0.0059 16.9 1.3 0.0059 16.9 1.3 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 1 TPR_MalT PF17874.1 AAS52200.1 - 0.011 15.1 1.3 0.017 14.5 1.1 1.4 1 1 0 1 1 1 0 MalT-like TPR region TPR_16 PF13432.6 AAS52200.1 - 0.09 13.4 7.9 0.17 12.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_15 PF13429.6 AAS52200.1 - 0.11 11.6 6.4 0.019 14.2 1.5 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Cep57_CLD PF14073.6 AAS52200.1 - 0.16 12.0 8.2 0.21 11.6 5.6 2.1 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 TPR_2 PF07719.17 AAS52200.1 - 0.3 11.3 0.2 0.3 11.3 0.2 5.0 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 AAS52200.1 - 0.52 10.7 0.1 0.52 10.7 0.1 2.8 1 1 1 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 AAS52200.1 - 1.2 9.0 5.1 6.2 6.8 0.2 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4600 PF15372.6 AAS52200.1 - 1.9 8.9 6.1 1.5 9.2 3.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4600) zf-met PF12874.7 AAS52201.2 - 1.7e-06 28.2 0.5 3.1e-06 27.4 0.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AAS52201.2 - 1.7e-05 25.0 1.2 3.2e-05 24.1 1.2 1.5 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF759 PF05537.11 AAS52201.2 - 0.0043 16.0 0.4 0.077 11.9 0.3 2.1 1 1 1 2 2 2 1 Borrelia burgdorferi protein of unknown function (DUF759) DUF629 PF04780.12 AAS52201.2 - 0.0072 14.9 0.2 0.0096 14.5 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 AAS52201.2 - 0.029 14.8 1.2 0.065 13.7 1.2 1.7 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS52201.2 - 0.053 14.4 0.3 0.13 13.1 0.3 1.7 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 AAS52201.2 - 0.063 13.6 1.7 0.1 13.0 1.7 1.3 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-DBF PF07535.12 AAS52201.2 - 0.32 11.1 2.9 0.2 11.8 0.6 1.9 2 0 0 2 2 2 0 DBF zinc finger Ribosomal_S8 PF00410.19 AAS52203.1 - 5.1e-11 42.6 0.0 5.7e-10 39.2 0.0 1.9 1 1 0 1 1 1 1 Ribosomal protein S8 BST2 PF16716.5 AAS52204.1 - 0.021 15.4 11.4 0.021 15.4 11.4 2.8 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 Baculo_PEP_C PF04513.12 AAS52204.1 - 0.18 11.8 5.6 0.28 11.2 5.6 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 AAS52204.1 - 0.2 10.5 20.6 0.015 14.2 11.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 AAS52204.1 - 0.29 11.4 17.9 0.27 11.5 8.7 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF848 PF05852.11 AAS52204.1 - 0.6 10.2 12.0 0.073 13.2 5.8 2.2 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) APG6_N PF17675.1 AAS52204.1 - 0.67 10.5 25.6 0.17 12.4 17.1 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 AAS52204.1 - 2.1 8.1 17.4 1.1 9.0 8.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) She9_MDM33 PF05546.11 AAS52204.1 - 3.9 7.2 17.2 0.27 11.0 7.4 2.4 2 1 0 2 2 2 0 She9 / Mdm33 family THOC7 PF05615.13 AAS52204.1 - 4.2 7.7 22.3 0.31 11.3 12.5 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 GAS PF13851.6 AAS52204.1 - 4.5 6.6 23.1 0.27 10.5 9.2 2.5 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Bcr-Abl_Oligo PF09036.10 AAS52204.1 - 7 6.7 15.5 1.7 8.7 1.7 3.3 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain CENP-H PF05837.12 AAS52204.1 - 8.4 6.9 18.1 1.9 8.9 10.1 2.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ArsA_ATPase PF02374.15 AAS52205.2 - 4.9e-115 383.9 0.0 5.7e-115 383.7 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase AAA_31 PF13614.6 AAS52205.2 - 2.8e-09 37.1 1.1 1.7e-08 34.6 0.1 2.5 2 1 0 2 2 2 1 AAA domain CbiA PF01656.23 AAS52205.2 - 2.7e-08 33.9 0.0 6.2e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Fer4_NifH PF00142.18 AAS52205.2 - 0.001 18.6 0.0 0.0018 17.7 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 AAS52205.2 - 0.0025 17.3 1.3 0.008 15.7 0.5 2.1 2 1 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase AAA_25 PF13481.6 AAS52205.2 - 0.013 15.1 0.0 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 AAS52205.2 - 0.032 13.8 0.1 0.66 9.6 0.0 2.3 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain PhoH PF02562.16 AAS52205.2 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 AAS52205.2 - 0.21 11.3 0.5 1.6 8.4 0.1 2.3 2 1 0 2 2 2 0 AAA domain Glyoxalase PF00903.25 AAS52206.1 - 1.6e-26 93.0 0.1 1.4e-15 57.6 0.0 2.7 2 1 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 AAS52206.1 - 1.5e-08 34.9 0.0 0.00016 22.0 0.0 3.5 1 1 2 3 3 3 3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AAS52206.1 - 0.00069 20.4 0.0 0.32 11.8 0.0 3.3 2 2 0 2 2 2 1 Glyoxalase-like domain CppA_N PF14506.6 AAS52206.1 - 0.002 18.2 0.1 0.11 12.5 0.0 2.4 2 0 0 2 2 2 1 CppA N-terminal Glyoxalase_3 PF13468.6 AAS52206.1 - 0.026 14.7 0.0 0.59 10.2 0.0 2.4 2 0 0 2 2 2 0 Glyoxalase-like domain Glyoxalase_2 PF12681.7 AAS52206.1 - 0.16 11.9 0.1 4.1 7.4 0.0 2.7 3 0 0 3 3 3 0 Glyoxalase-like domain HA2 PF04408.23 AAS52207.1 - 2.5e-16 59.9 0.1 2.3e-15 56.8 0.0 2.5 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AAS52207.1 - 3.1e-14 53.3 0.0 7.5e-14 52.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AAS52207.1 - 4.2e-13 49.5 0.0 8.5e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AAS52207.1 - 2.6e-05 24.1 0.0 6.6e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS52207.1 - 3.9e-05 24.0 0.1 0.00017 21.9 0.1 2.1 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 AAS52207.1 - 0.00049 19.2 0.1 0.0015 17.6 0.1 1.6 1 1 0 1 1 1 1 Type II/IV secretion system protein AAA_30 PF13604.6 AAS52207.1 - 0.00054 19.7 1.0 0.0017 18.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Alb1 PF09135.11 AAS52207.1 - 0.0041 18.0 1.6 0.012 16.5 1.6 1.8 1 0 0 1 1 1 1 Alb1 AAA_19 PF13245.6 AAS52207.1 - 0.0044 17.4 0.1 0.0096 16.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AAS52207.1 - 0.022 14.4 0.0 0.043 13.4 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_14 PF13173.6 AAS52207.1 - 0.12 12.4 0.1 2.3 8.3 0.1 2.5 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS52207.1 - 0.14 12.7 0.2 0.8 10.2 0.0 2.4 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 AAS52207.1 - 1.4 9.2 8.2 0.71 10.2 0.1 2.8 2 2 0 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 AAS52207.1 - 1.9 8.6 7.2 3.3 7.9 0.0 3.2 2 1 0 3 3 3 0 AAA domain PRK PF00485.18 AAS52208.2 - 9.9e-67 224.5 0.0 1.5e-66 224.0 0.0 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family UPRTase PF14681.6 AAS52208.2 - 8e-34 116.9 0.0 1.2e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase AAA_18 PF13238.6 AAS52208.2 - 9.6e-05 22.9 0.0 0.00029 21.4 0.0 1.8 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AAS52208.2 - 0.0009 18.6 0.0 0.0018 17.6 0.0 1.5 1 0 0 1 1 1 1 Zeta toxin CPT PF07931.12 AAS52208.2 - 0.0046 16.8 0.0 0.0094 15.8 0.0 1.5 1 0 0 1 1 1 1 Chloramphenicol phosphotransferase-like protein AAA_17 PF13207.6 AAS52208.2 - 0.016 15.7 0.9 5.8 7.3 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_33 PF13671.6 AAS52208.2 - 0.016 15.3 0.0 0.038 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain CoaE PF01121.20 AAS52208.2 - 0.11 12.2 0.1 15 5.2 0.1 2.5 2 0 0 2 2 2 0 Dephospho-CoA kinase SPX PF03105.19 AAS52209.2 - 2e-37 130.1 9.4 1.2e-22 81.4 2.8 2.8 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 AAS52209.2 - 2.7e-24 86.1 47.1 4.1e-24 85.5 47.1 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AAS52209.2 - 3.4e-22 79.0 79.4 3.4e-21 75.7 48.0 2.3 1 1 1 2 2 2 2 Citrate transporter GATase_2 PF00310.21 AAS52210.2 - 7.4e-168 558.6 0.0 1.6e-167 557.5 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferases class-II Glu_synthase PF01645.17 AAS52210.2 - 3.5e-155 516.7 0.0 1.9e-154 514.2 0.0 2.0 2 0 0 2 2 2 1 Conserved region in glutamate synthase Glu_syn_central PF04898.14 AAS52210.2 - 2.1e-114 381.8 0.0 4.7e-111 370.8 0.0 2.3 2 0 0 2 2 2 2 Glutamate synthase central domain GXGXG PF01493.19 AAS52210.2 - 2.9e-70 235.7 1.4 6.9e-70 234.5 1.4 1.7 1 0 0 1 1 1 1 GXGXG motif Fer4_20 PF14691.6 AAS52210.2 - 2.7e-23 81.9 0.1 5.1e-23 81.0 0.1 1.5 1 0 0 1 1 1 1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster Pyr_redox_2 PF07992.14 AAS52210.2 - 1.8e-21 76.7 0.2 2.3e-20 73.0 0.2 2.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AAS52210.2 - 6.5e-09 35.9 0.0 2e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 AAS52210.2 - 2.3e-08 34.5 0.3 3e-06 27.7 0.0 3.3 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 AAS52210.2 - 4.8e-06 26.1 0.0 1.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_3 PF13738.6 AAS52210.2 - 1.2e-05 24.8 0.1 0.013 14.8 0.0 3.2 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AAS52210.2 - 5.3e-05 22.1 1.3 5.8e-05 22.0 0.0 1.7 2 0 0 2 2 2 1 HI0933-like protein DAO PF01266.24 AAS52210.2 - 7.3e-05 22.5 0.1 0.00031 20.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AAS52210.2 - 0.0002 20.6 0.0 0.00036 19.7 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 AAS52210.2 - 0.00066 19.0 0.0 0.0013 18.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AAS52210.2 - 0.0007 19.1 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 AAS52210.2 - 0.009 15.3 0.0 0.025 13.8 0.0 1.7 1 0 0 1 1 1 1 Thi4 family NAD_binding_7 PF13241.6 AAS52210.2 - 0.01 16.3 0.6 1.2 9.6 0.0 2.8 2 0 0 2 2 2 0 Putative NAD(P)-binding GIDA PF01134.22 AAS52210.2 - 0.012 14.8 0.2 0.082 12.0 0.0 2.3 2 0 0 2 2 2 0 Glucose inhibited division protein A AdoHcyase_NAD PF00670.21 AAS52210.2 - 0.03 14.4 0.7 15 5.6 0.0 3.3 3 0 0 3 3 3 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain FMN_dh PF01070.18 AAS52210.2 - 0.053 12.6 0.8 0.24 10.4 0.7 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase NAD_binding_9 PF13454.6 AAS52210.2 - 0.065 13.2 0.2 1.2 9.1 0.0 2.9 3 0 0 3 3 3 0 FAD-NAD(P)-binding GATase_6 PF13522.6 AAS52210.2 - 0.067 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 Glutamine amidotransferase domain AlaDh_PNT_C PF01262.21 AAS52210.2 - 0.074 12.3 0.0 5.3 6.3 0.0 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AAS52210.2 - 0.088 12.2 0.0 1.3 8.4 0.0 2.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Lycopene_cycl PF05834.12 AAS52210.2 - 0.12 11.4 0.1 0.22 10.5 0.1 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Mu-like_Pro PF10123.9 AAS52210.2 - 0.16 11.5 1.9 0.59 9.6 2.4 1.6 2 0 0 2 2 2 0 Mu-like prophage I protein DUF3602 PF12223.8 AAS52211.1 - 5.6e-21 74.9 4.8 9.4e-10 39.0 0.0 3.0 1 1 2 3 3 3 3 Protein of unknown function (DUF3602) GTP1_OBG PF01018.22 AAS52211.1 - 0.67 9.5 4.3 4.4 6.9 0.1 2.8 2 1 1 3 3 3 0 GTP1/OBG PNPase_C PF12111.8 AAS52211.1 - 5.9 6.4 7.0 11 5.6 0.0 3.1 3 0 0 3 3 3 0 Polyribonucleotide phosphorylase C terminal Cnd3 PF12719.7 AAS52212.2 - 3.3e-94 315.4 6.0 4.9e-94 314.8 4.5 2.1 2 1 1 3 3 3 1 Nuclear condensing complex subunits, C-term domain HEAT_2 PF13646.6 AAS52212.2 - 4.5e-08 33.4 0.8 0.0044 17.4 0.1 4.1 3 0 0 3 3 3 2 HEAT repeats HEAT PF02985.22 AAS52212.2 - 1.7e-06 27.8 4.5 1.2 9.5 0.0 6.1 7 0 0 7 7 7 2 HEAT repeat Cnd1 PF12717.7 AAS52212.2 - 6.2e-06 26.3 5.0 7.7e-05 22.8 0.2 3.8 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 AAS52212.2 - 0.021 15.4 0.2 51 4.5 0.0 4.4 3 1 1 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AAS52212.2 - 0.05 14.2 0.1 0.64 10.6 0.1 3.1 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region DUF4776 PF16003.5 AAS52212.2 - 0.23 10.4 3.3 0.4 9.6 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF1848 PF08902.11 AAS52212.2 - 0.36 10.5 2.2 0.35 10.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) Ribonuc_2-5A PF06479.12 AAS52213.2 - 1.7e-44 151.0 0.6 3.6e-44 150.0 0.6 1.6 1 0 0 1 1 1 1 Ribonuclease 2-5A Pkinase PF00069.25 AAS52213.2 - 1.2e-41 142.8 0.0 4.2e-30 105.0 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52213.2 - 2.2e-23 82.9 0.0 5.8e-21 74.9 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase PQQ PF01011.21 AAS52213.2 - 0.00035 20.3 3.9 0.68 10.0 0.0 3.7 4 0 0 4 4 4 2 PQQ enzyme repeat Kdo PF06293.14 AAS52213.2 - 0.0014 18.0 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 AAS52213.2 - 0.039 12.7 0.2 0.1 11.4 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase PQQ_2 PF13360.6 AAS52213.2 - 0.046 13.3 0.0 0.19 11.3 0.0 1.9 1 1 0 1 1 1 0 PQQ-like domain Swi5 PF07061.11 AAS52214.1 - 1.8e-23 82.4 0.6 2.2e-23 82.1 0.6 1.1 1 0 0 1 1 1 1 Swi5 Bap31_Bap29_C PF18035.1 AAS52214.1 - 0.00046 20.1 4.2 0.00073 19.5 3.8 1.6 1 1 0 1 1 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain Spc24 PF08286.11 AAS52214.1 - 0.0059 16.8 0.8 0.0086 16.3 0.8 1.5 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 Mod_r PF07200.13 AAS52214.1 - 0.0069 16.5 1.1 0.011 15.9 0.8 1.4 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein PhetRS_B1 PF18262.1 AAS52214.1 - 0.086 13.1 1.0 0.29 11.4 0.1 2.0 1 1 1 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain VASt PF16016.5 AAS52215.2 - 2.3e-73 245.7 0.1 2.2e-36 125.6 0.0 2.8 2 0 0 2 2 2 2 VAD1 Analog of StAR-related lipid transfer domain GRAM PF02893.20 AAS52215.2 - 8e-27 93.4 0.2 1.8e-26 92.3 0.2 1.6 1 0 0 1 1 1 1 GRAM domain PKcGMP_CC PF16808.5 AAS52215.2 - 0.3 11.0 3.3 0.64 9.9 3.3 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Skp1 PF01466.19 AAS52216.1 - 2.2e-24 85.3 0.3 4.2e-24 84.4 0.3 1.5 1 0 0 1 1 1 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 AAS52216.1 - 1.7e-14 53.7 0.0 8.8e-07 29.0 0.0 2.4 2 0 0 2 2 2 2 Skp1 family, tetramerisation domain Peroxin-3 PF04882.12 AAS52217.1 - 2.2e-109 366.6 7.9 7.2e-87 292.3 2.0 2.0 1 1 1 2 2 2 2 Peroxin-3 Sas10_Utp3 PF04000.15 AAS52218.1 - 0.00035 21.1 0.2 0.00075 20.1 0.2 1.5 1 1 0 1 1 1 1 Sas10/Utp3/C1D family Trimer_CC PF08954.11 AAS52218.1 - 0.14 11.7 3.2 1.1 8.9 0.3 2.4 2 0 0 2 2 2 0 Trimerisation motif Thioredoxin_7 PF13899.6 AAS52219.2 - 1.7e-22 79.4 0.1 2.8e-22 78.7 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like UBX PF00789.20 AAS52219.2 - 1.1e-15 57.6 0.1 3e-15 56.2 0.0 1.8 2 0 0 2 2 2 1 UBX domain UBA_4 PF14555.6 AAS52219.2 - 2e-12 46.7 0.0 4.3e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain gp45-slide_C PF09116.10 AAS52219.2 - 0.15 12.1 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 gp45 sliding clamp, C terminal Peptidase_C13 PF01650.18 AAS52220.1 - 1.2e-47 162.6 2.0 1.6e-47 162.2 2.0 1.1 1 0 0 1 1 1 1 Peptidase C13 family Pkinase PF00069.25 AAS52221.1 - 4.9e-48 163.8 1.6 2.9e-43 148.1 0.2 2.2 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52221.1 - 4.3e-25 88.5 0.1 3e-24 85.7 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52221.1 - 4.7e-09 36.0 0.0 1.5e-08 34.3 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AAS52221.1 - 0.069 11.9 0.1 0.069 11.9 0.1 1.8 2 0 0 2 2 2 0 Fungal protein kinase YtfJ_HI0045 PF09695.10 AAS52221.1 - 0.11 12.1 1.5 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (YtfJ_HI0045) FTA2 PF13095.6 AAS52221.1 - 0.12 12.0 0.4 1.8 8.1 0.4 2.5 1 1 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 ResIII PF04851.15 AAS52222.1 - 8.5e-25 87.7 0.0 2.1e-24 86.4 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS52222.1 - 3.7e-16 59.4 0.0 7e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52222.1 - 7.4e-13 48.8 0.2 8e-12 45.5 0.1 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SWI2_SNF2 PF18766.1 AAS52222.1 - 1.5e-07 31.3 0.7 3e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 SWI2/SNF2 ATPase AAA_22 PF13401.6 AAS52222.1 - 5.8e-06 26.6 0.2 4.5e-05 23.7 0.1 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 AAS52222.1 - 4.1e-05 23.0 0.1 9.5e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Pox_E2-like PF04497.12 AAS52222.1 - 0.00012 20.8 0.1 0.28 9.6 0.0 2.2 2 0 0 2 2 2 2 Poxviridae protein ERCC3_RAD25_C PF16203.5 AAS52222.1 - 0.0017 17.6 0.0 0.0042 16.3 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_11 PF13086.6 AAS52222.1 - 0.0028 17.5 1.8 0.39 10.5 0.3 3.0 2 1 1 3 3 3 1 AAA domain Flavi_DEAD PF07652.14 AAS52222.1 - 0.0076 16.2 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Flavivirus DEAD domain SNF2_N PF00176.23 AAS52222.1 - 0.088 11.5 0.0 0.2 10.3 0.0 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain CbiA PF01656.23 AAS52222.1 - 0.11 12.5 0.0 4 7.5 0.0 2.9 3 1 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain SAM35 PF10806.8 AAS52223.2 - 3.6e-34 117.8 0.0 6.3e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 SAM35, subunit of SAM coomplex STE PF02200.16 AAS52224.2 - 4.7e-60 200.8 1.6 7.5e-60 200.1 1.6 1.3 1 0 0 1 1 1 1 STE like transcription factor CENP-B_dimeris PF09026.10 AAS52224.2 - 1.9 9.0 15.3 5.9 7.4 7.7 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Tcf25 PF04910.14 AAS52225.2 - 1.1e-74 251.6 0.0 1.6e-74 251.1 0.0 1.2 1 0 0 1 1 1 1 Transcriptional repressor TCF25 baeRF_family8 PF18851.1 AAS52225.2 - 0.69 10.0 5.4 0.85 9.7 2.3 2.2 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 8 PGA2 PF07543.12 AAS52225.2 - 2.1 8.3 9.2 4 7.4 9.2 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Ipi1_N PF12333.8 AAS52226.2 - 9.2e-24 84.0 0.0 2.3e-23 82.7 0.0 1.7 1 0 0 1 1 1 1 Rix1 complex component involved in 60S ribosome maturation RRM_1 PF00076.22 AAS52227.2 - 3.7e-45 151.6 0.0 2.3e-17 62.6 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS52227.2 - 0.00017 21.6 0.1 0.037 14.2 0.0 3.5 3 1 0 3 3 3 1 RNA recognition motif RRM_3 PF08777.11 AAS52227.2 - 0.0017 18.4 0.0 0.0057 16.7 0.0 1.9 2 1 0 2 2 2 1 RNA binding motif RRM_occluded PF16842.5 AAS52227.2 - 0.0057 16.5 0.0 0.91 9.4 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif SUIM_assoc PF16619.5 AAS52227.2 - 0.0068 16.4 1.9 0.0068 16.4 1.9 3.5 2 1 1 3 3 2 1 Unstructured region C-term to UIM in Ataxin3 Nup35_RRM_2 PF14605.6 AAS52227.2 - 0.017 15.1 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif API5 PF05918.11 AAS52227.2 - 0.058 12.2 8.6 0.089 11.6 8.6 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) FHIPEP PF00771.20 AAS52227.2 - 0.22 9.9 1.1 0.3 9.5 1.1 1.1 1 0 0 1 1 1 0 FHIPEP family DUF4834 PF16118.5 AAS52227.2 - 2.5 9.1 5.8 8.6 7.4 5.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pex14_N PF04695.13 AAS52227.2 - 3.6 8.2 30.6 0.69 10.6 15.8 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Caskin1-CID PF16600.5 AAS52227.2 - 5.1 7.8 8.2 4.1 8.1 1.2 3.0 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain zf-C2H2 PF00096.26 AAS52228.1 - 6.6e-08 32.6 12.8 0.00016 22.0 2.7 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS52228.1 - 3.7e-05 24.2 11.0 0.0086 16.8 1.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS52228.1 - 0.0021 18.4 1.7 0.0021 18.4 1.7 2.8 3 0 0 3 3 3 1 Zinc-finger double domain zf-met PF12874.7 AAS52228.1 - 0.17 12.3 0.4 0.17 12.3 0.4 2.7 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-BED PF02892.15 AAS52228.1 - 0.21 11.7 3.2 0.18 11.9 1.2 1.9 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_jaz PF12171.8 AAS52228.1 - 0.5 10.7 4.4 0.47 10.8 0.2 2.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding SNF2_N PF00176.23 AAS52229.2 - 9e-67 225.2 0.2 1.8e-66 224.3 0.2 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS52229.2 - 1.6e-18 67.0 0.0 4.9e-17 62.3 0.0 3.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HSA PF07529.13 AAS52229.2 - 4.1e-13 49.5 11.0 4.1e-13 49.5 11.0 2.6 1 1 1 2 2 2 1 HSA ResIII PF04851.15 AAS52229.2 - 1.6e-12 47.7 0.0 1.6e-12 47.7 0.0 3.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS52229.2 - 5.2e-07 29.6 0.0 4.9e-06 26.4 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase HemY_N PF07219.13 AAS52229.2 - 6.3 7.1 10.6 4.3 7.6 3.7 2.5 2 0 0 2 2 2 0 HemY protein N-terminus NARP1 PF12569.8 AAS52230.2 - 8.5e-110 368.1 15.9 3.1e-83 280.4 3.2 3.9 2 2 1 3 3 3 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 AAS52230.2 - 1.3e-12 46.8 16.4 0.011 15.8 0.0 8.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 AAS52230.2 - 1.2e-10 41.9 4.2 0.16 12.7 0.0 6.5 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 AAS52230.2 - 2.5e-09 37.2 5.0 0.11 13.3 0.0 7.7 9 1 1 10 10 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS52230.2 - 1.6e-07 31.4 12.9 0.00061 20.0 0.0 5.2 5 1 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 AAS52230.2 - 6.5e-05 22.8 11.4 7.7 7.0 0.1 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS52230.2 - 8.7e-05 22.2 13.4 0.23 11.3 0.0 7.1 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS52230.2 - 0.00018 21.9 5.4 33 5.1 0.1 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 AAS52230.2 - 0.0015 18.8 5.0 3.6 8.2 0.0 6.4 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_9 PF13371.6 AAS52230.2 - 0.0038 17.3 0.0 22 5.3 0.0 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS52230.2 - 0.0074 16.3 6.2 0.42 10.8 0.0 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AAS52230.2 - 0.013 15.6 4.9 0.31 11.1 0.1 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Sel1 PF08238.12 AAS52230.2 - 0.019 15.6 0.5 0.41 11.4 0.0 3.5 3 0 0 3 3 3 0 Sel1 repeat TPR_12 PF13424.6 AAS52230.2 - 0.032 14.5 14.6 0.38 11.1 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 AAS52230.2 - 0.043 13.7 4.7 0.25 11.3 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat HrcA_DNA-bdg PF03444.15 AAS52230.2 - 0.14 11.8 0.6 1.1 8.9 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF5475 PF17569.2 AAS52230.2 - 0.15 12.4 0.2 0.46 10.8 0.1 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5475) TPR_6 PF13174.6 AAS52230.2 - 1.2 9.9 7.8 35 5.3 0.0 5.3 5 0 0 5 5 4 0 Tetratricopeptide repeat NAD_Gly3P_dh_N PF01210.23 AAS52231.1 - 1.1e-51 174.9 0.1 2.1e-51 174.0 0.1 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 AAS52231.1 - 8e-43 146.1 0.0 1.4e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus F420_oxidored PF03807.17 AAS52231.1 - 0.03 14.9 0.0 16 6.2 0.0 2.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent 3HCDH_N PF02737.18 AAS52231.1 - 0.13 12.1 0.0 1.9 8.3 0.0 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF21 PF01595.20 AAS52232.2 - 1.4e-33 116.0 0.0 3e-33 115.0 0.0 1.5 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 AAS52232.2 - 0.00017 22.0 0.0 0.24 11.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain Pkinase PF00069.25 AAS52233.2 - 6.3e-51 173.3 0.0 9.4e-51 172.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52233.2 - 8.1e-25 87.6 0.0 1.2e-24 87.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52233.2 - 0.0015 18.0 0.0 0.0029 17.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AAS52233.2 - 0.0067 16.4 0.1 0.18 11.7 0.1 2.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family FTA2 PF13095.6 AAS52233.2 - 0.016 14.8 0.0 1 8.9 0.0 2.3 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 AAS52233.2 - 0.19 11.1 0.2 0.36 10.2 0.2 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pribosyl_synth PF14572.6 AAS52234.2 - 6.4e-39 133.9 0.6 1.1e-38 133.1 0.1 1.7 2 0 0 2 2 2 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AAS52234.2 - 1.1e-36 125.3 0.3 3.7e-36 123.6 0.0 2.1 3 0 0 3 3 3 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AAS52234.2 - 1.4e-10 40.9 0.8 8.7e-10 38.3 0.8 2.1 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AAS52234.2 - 0.008 15.6 0.2 0.014 14.8 0.2 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase ZNRF_3_ecto PF18212.1 AAS52234.2 - 0.12 12.4 0.2 0.59 10.2 0.0 2.1 2 0 0 2 2 2 0 ZNRF-3 Ectodomain Adap_comp_sub PF00928.21 AAS52235.2 - 8e-79 264.7 0.1 9.7e-79 264.4 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AAS52235.2 - 0.08 12.9 0.0 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 Clathrin adaptor complex small chain Actin PF00022.19 AAS52236.1 - 7.8e-110 367.3 0.0 2.5e-109 365.6 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AAS52236.1 - 0.0042 16.0 0.0 0.025 13.4 0.0 2.1 1 1 0 1 1 1 1 MreB/Mbl protein Pkinase PF00069.25 AAS52237.2 - 2.4e-51 174.6 0.0 9.7e-51 172.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52237.2 - 6e-23 81.4 0.4 8.2e-17 61.3 0.1 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase FTA2 PF13095.6 AAS52237.2 - 0.00014 21.6 0.1 0.3 10.7 0.0 2.6 2 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 AAS52237.2 - 0.00028 20.9 0.0 0.57 10.1 0.0 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family RIO1 PF01163.22 AAS52237.2 - 0.0025 17.4 0.4 0.0056 16.3 0.4 1.5 1 0 0 1 1 1 1 RIO1 family ASF1_hist_chap PF04729.13 AAS52240.2 - 6.7e-71 237.2 0.0 9e-71 236.8 0.0 1.2 1 0 0 1 1 1 1 ASF1 like histone chaperone BUD22 PF09073.10 AAS52240.2 - 3.2 7.0 33.4 3.6 6.8 33.4 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 AAS52240.2 - 3.6 6.9 37.2 4.1 6.7 37.2 1.1 1 0 0 1 1 1 0 SDA1 Mg_trans_NIPA PF05653.14 AAS52241.1 - 1.9e-13 50.2 9.0 3e-08 33.1 0.3 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA ESSS PF10183.9 AAS52241.1 - 0.14 12.4 0.1 0.3 11.3 0.1 1.5 1 0 0 1 1 1 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Multi_Drug_Res PF00893.19 AAS52241.1 - 9.3 7.0 10.1 0.28 11.9 1.7 2.5 2 0 0 2 2 2 0 Small Multidrug Resistance protein SUN PF03856.13 AAS52242.1 - 2.2e-95 318.8 12.1 2.9e-95 318.4 12.1 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) zf-MYND PF01753.18 AAS52242.1 - 0.045 13.9 1.1 0.1 12.7 1.1 1.5 1 0 0 1 1 1 0 MYND finger His_Phos_1 PF00300.22 AAS52243.1 - 4.9e-35 121.0 0.1 6.4e-35 120.6 0.1 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Lectin_leg-like PF03388.13 AAS52244.2 - 1.2e-11 44.4 0.0 6.5e-09 35.5 0.0 2.2 2 0 0 2 2 2 2 Legume-like lectin family Bact_lectin PF18483.1 AAS52244.2 - 0.00037 20.6 0.0 0.00066 19.8 0.0 1.3 1 1 0 1 1 1 1 Bacterial lectin Pho86 PF11124.8 AAS52245.2 - 4.4e-104 348.0 0.5 4.9e-104 347.9 0.5 1.0 1 0 0 1 1 1 1 Inorganic phosphate transporter Pho86 DUF1409 PF07197.12 AAS52245.2 - 0.17 11.8 0.0 0.47 10.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) EBP50_C PF09007.11 AAS52246.2 - 8.8 7.3 10.0 1.4 10.0 3.4 2.3 1 1 1 2 2 2 0 EBP50, C-terminal Glyco_hydro_28 PF00295.17 AAS52247.1 - 8.6e-87 291.2 10.8 9.9e-87 291.0 10.8 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 28 Beta_helix PF13229.6 AAS52247.1 - 4.6e-05 23.3 4.3 4.6e-05 23.3 4.3 3.0 2 1 0 3 3 3 2 Right handed beta helix region Pam17 PF08566.10 AAS52248.1 - 5.9e-63 211.6 0.0 6.7e-63 211.4 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial import protein Pam17 PRF PF06875.11 AAS52248.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF CRT10 PF08728.10 AAS52249.2 - 2e-272 905.6 0.0 2.3e-272 905.4 0.0 1.0 1 0 0 1 1 1 1 CRT10 MFS_1 PF07690.16 AAS52250.1 - 9e-36 123.5 29.4 1.3e-35 123.0 29.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily PspB PF06667.12 AAS52250.1 - 0.024 14.7 0.0 0.069 13.2 0.0 1.7 1 0 0 1 1 1 0 Phage shock protein B MFS_1_like PF12832.7 AAS52250.1 - 0.2 10.5 14.4 0.33 9.8 5.3 2.4 2 1 0 2 2 2 0 MFS_1 like family Raptor_N PF14538.6 AAS52251.2 - 8.1e-68 227.0 3.9 1.4e-67 226.2 0.0 2.5 2 0 0 2 2 2 1 Raptor N-terminal CASPase like domain WD40 PF00400.32 AAS52251.2 - 6.4e-05 23.7 9.5 3.5 8.6 0.0 6.4 7 1 0 7 7 7 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 AAS52251.2 - 0.00048 20.1 0.0 0.014 15.4 0.0 3.2 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region HEAT PF02985.22 AAS52251.2 - 0.0022 18.1 1.8 0.28 11.6 0.0 4.6 5 0 0 5 5 5 1 HEAT repeat Elong_Iki1 PF10483.9 AAS52252.1 - 1.4e-67 228.3 0.0 1.6e-67 228.1 0.0 1.0 1 0 0 1 1 1 1 Elongator subunit Iki1 Gpi16 PF04113.14 AAS52253.2 - 9.9e-189 628.4 0.0 1.3e-188 628.0 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component HEAT_2 PF13646.6 AAS52254.2 - 4.1e-07 30.3 6.6 4.3 7.8 0.0 7.8 6 3 2 9 9 9 2 HEAT repeats Vac14_Fab1_bd PF12755.7 AAS52254.2 - 8.7e-07 29.5 0.1 0.43 11.2 0.1 4.4 3 1 0 3 3 3 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 AAS52254.2 - 2.4e-05 24.7 5.9 0.078 13.5 0.0 7.3 8 0 0 8 8 8 1 HEAT-like repeat HEAT PF02985.22 AAS52254.2 - 2.8e-05 24.0 16.1 0.15 12.4 0.0 9.0 11 0 0 11 11 11 2 HEAT repeat Cnd1 PF12717.7 AAS52254.2 - 0.00041 20.4 2.7 7.6 6.6 0.0 4.9 4 1 1 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 AAS52254.2 - 0.0049 15.5 2.4 0.9 8.0 1.9 3.2 1 1 0 1 1 1 1 Adaptin N terminal region MMS19_C PF12460.8 AAS52254.2 - 0.013 14.6 0.0 8.2 5.4 0.1 3.4 3 0 0 3 3 3 0 RNAPII transcription regulator C-terminal NUC173 PF08161.12 AAS52254.2 - 0.02 14.6 0.1 1.1 8.9 0.0 3.1 3 0 0 3 3 3 0 NUC173 domain UME PF08064.13 AAS52254.2 - 0.065 13.2 0.0 4.7 7.2 0.0 3.6 3 0 0 3 3 3 0 UME (NUC010) domain Adaptin_N PF01602.20 AAS52255.2 - 3.3e-89 299.8 12.8 3.9e-89 299.6 12.8 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AAS52255.2 - 1.6e-14 54.2 13.0 3.6e-13 49.9 1.3 4.7 3 2 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AAS52255.2 - 3.4e-10 39.3 5.9 0.0078 16.4 0.0 6.3 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 AAS52255.2 - 4.7e-08 33.3 0.8 3.2e-05 24.2 0.1 4.4 3 2 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 AAS52255.2 - 0.002 18.6 2.4 5.4 7.6 0.1 4.1 5 0 0 5 5 5 2 HEAT-like repeat Cohesin_HEAT PF12765.7 AAS52255.2 - 0.0055 17.0 7.7 0.52 10.7 0.2 4.4 4 0 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion RTTN_N PF14726.6 AAS52255.2 - 0.058 14.2 0.1 9.3 7.1 0.1 3.1 2 0 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning DUF5578 PF17741.1 AAS52255.2 - 0.21 11.0 2.5 6 6.2 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5578) Vac14_Fab1_bd PF12755.7 AAS52255.2 - 0.24 12.0 1.2 2.2 8.9 0.1 2.8 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region RasGEF_N_2 PF14663.6 AAS52255.2 - 0.39 11.1 2.5 9.7 6.6 0.1 3.2 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain MFS_1 PF07690.16 AAS52256.1 - 1.5e-33 116.2 19.2 1.5e-33 116.2 19.2 1.9 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_1 PF07690.16 AAS52257.1 - 2e-27 96.0 35.7 2e-26 92.7 30.7 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Ssl1 PF04056.14 AAS52258.1 - 6.1e-87 290.4 0.1 8.2e-87 290.0 0.1 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 AAS52258.1 - 8.5e-26 90.0 14.1 8.5e-26 90.0 14.1 2.7 2 0 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 AAS52258.1 - 2.2e-15 57.2 0.0 4.5e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 AAS52258.1 - 6.3e-05 23.3 0.0 0.0001 22.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain Tfb4 PF03850.14 AAS52258.1 - 3.1 7.2 8.7 9.5 5.6 8.7 1.8 1 0 0 1 1 1 0 Transcription factor Tfb4 PBP1_TM PF14812.6 AAS52258.1 - 3.3 8.2 8.0 6.9 7.1 8.0 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DZR PF12773.7 AAS52258.1 - 6.4 6.9 25.6 0.66 10.0 6.9 3.4 2 1 0 2 2 2 0 Double zinc ribbon Glyco_hydro_92 PF07971.12 AAS52259.3 - 4.9e-118 395.0 0.1 6.3e-118 394.6 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 AAS52259.3 - 9.2e-46 156.7 3.5 1.3e-45 156.2 3.5 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain CMS1 PF14617.6 AAS52261.1 - 1.8e-19 70.1 8.8 7.2e-13 48.5 7.3 2.8 2 1 0 2 2 2 2 U3-containing 90S pre-ribosomal complex subunit FliJ PF02050.16 AAS52261.1 - 0.06 13.6 4.5 0.13 12.5 4.5 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein VitD-bind_III PF09164.10 AAS52261.1 - 0.062 13.3 0.8 1.7 8.7 0.0 2.5 1 1 1 2 2 2 0 Vitamin D binding protein, domain III CH PF00307.31 AAS52261.1 - 0.28 11.4 2.0 20 5.4 0.0 3.4 3 1 0 3 3 3 0 Calponin homology (CH) domain SWI-SNF_Ssr4 PF08549.10 AAS52261.1 - 0.39 9.3 5.2 0.56 8.8 5.2 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF1764 PF08576.10 AAS52261.1 - 0.52 11.2 8.4 1.3 9.9 4.4 2.3 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Adaptin_N PF01602.20 AAS52262.2 - 1.8e-86 290.8 16.4 2.3e-86 290.4 16.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AAS52262.2 - 1.4e-17 64.2 8.7 1.2e-15 57.9 1.7 2.5 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AAS52262.2 - 5.1e-05 23.6 0.0 2 8.9 0.0 3.9 3 1 0 3 3 3 2 HEAT repeats Response_reg PF00072.24 AAS52263.2 - 1.9e-20 73.1 0.0 8.9e-13 48.4 0.0 2.3 1 1 1 2 2 2 2 Response regulator receiver domain SMC_Nse1 PF07574.13 AAS52264.2 - 3e-37 128.4 0.0 4.8e-37 127.8 0.0 1.3 1 0 0 1 1 1 1 Nse1 non-SMC component of SMC5-6 complex zf-RING-like PF08746.11 AAS52264.2 - 3.1e-09 37.0 11.8 6.2e-09 36.0 11.8 1.5 1 0 0 1 1 1 1 RING-like domain RecR PF02132.15 AAS52264.2 - 0.32 10.6 0.2 0.32 10.6 0.2 2.0 2 0 0 2 2 2 0 RecR protein PhnA_Zn_Ribbon PF08274.12 AAS52264.2 - 0.75 9.8 5.4 14 5.7 1.4 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon Pam16 PF03656.13 AAS52265.1 - 0.00021 21.3 0.0 0.00027 21.0 0.0 1.2 1 0 0 1 1 1 1 Pam16 DnaJ PF00226.31 AAS52265.1 - 0.0012 19.0 0.1 0.0021 18.2 0.1 1.4 1 0 0 1 1 1 1 DnaJ domain Ribosomal_L24e PF01246.20 AAS52266.1 - 1.1e-32 112.1 3.5 2.6e-32 110.8 3.5 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e GCD14 PF08704.10 AAS52267.2 - 4.6e-06 26.5 0.0 0.00086 19.1 0.0 2.7 3 0 0 3 3 3 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 AAS52267.2 - 0.0002 21.1 0.0 0.00046 20.0 0.0 1.6 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term DUF3775 PF12616.8 AAS52267.2 - 0.029 14.4 0.0 0.062 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) Methyltransf_24 PF13578.6 AAS52267.2 - 0.049 14.6 0.0 0.083 13.9 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 AAS52267.2 - 0.092 12.5 0.0 0.23 11.2 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Ribosomal_L28e PF01778.17 AAS52269.1 - 5e-39 133.6 2.2 5e-39 133.6 2.2 1.6 2 0 0 2 2 2 1 Ribosomal L28e protein family Mak16 PF04874.14 AAS52269.1 - 5.7e-29 100.7 12.4 5.7e-29 100.7 12.4 2.7 2 1 1 3 3 3 1 Mak16 protein C-terminal region BUD22 PF09073.10 AAS52269.1 - 0.0016 17.8 16.1 0.0022 17.4 16.1 1.2 1 0 0 1 1 1 1 BUD22 Ribosomal_L24e PF01246.20 AAS52269.1 - 0.0035 17.5 0.3 0.0096 16.1 0.3 1.8 1 0 0 1 1 1 1 Ribosomal protein L24e PYC_OADA PF02436.18 AAS52269.1 - 0.12 12.1 0.2 0.19 11.4 0.2 1.5 1 0 0 1 1 1 0 Conserved carboxylase domain SAPS PF04499.15 AAS52269.1 - 6.5 5.4 9.6 8.8 5.0 9.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2722 PF10846.8 AAS52269.1 - 8.1 5.3 8.7 10 4.9 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) PhoLip_ATPase_C PF16212.5 AAS52270.2 - 2.7e-83 279.5 26.8 2.7e-83 279.5 26.8 2.7 3 0 0 3 3 3 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AAS52270.2 - 1.5e-24 85.5 3.9 4.4e-24 84.0 3.9 1.9 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 AAS52270.2 - 2.8e-11 44.1 0.1 3.1e-05 24.3 0.0 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS52270.2 - 9.3e-10 38.5 0.0 4.9e-09 36.1 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AAS52270.2 - 1.4e-06 28.0 0.8 3.9e-06 26.5 0.0 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AAS52270.2 - 0.0011 18.8 0.2 0.017 14.9 0.0 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AAS52270.2 - 0.074 13.1 0.1 0.25 11.4 0.1 1.9 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DNA_III_psi PF03603.13 AAS52270.2 - 0.14 12.4 0.4 0.31 11.3 0.4 1.5 1 0 0 1 1 1 0 DNA polymerase III psi subunit Aldedh PF00171.22 AAS52271.2 - 1.8e-11 43.2 2.2 4.5e-09 35.3 1.0 2.4 2 1 0 2 2 2 2 Aldehyde dehydrogenase family Saw1 PF11561.8 AAS52272.2 - 2.6e-71 240.0 0.0 2.9e-71 239.9 0.0 1.0 1 0 0 1 1 1 1 Single strand annealing-weakened 1 Myosin_head PF00063.21 AAS52274.1 - 5.4e-281 933.7 7.7 9e-281 933.0 7.7 1.4 1 0 0 1 1 1 1 Myosin head (motor domain) DIL PF01843.19 AAS52274.1 - 4.9e-25 87.8 1.6 4.9e-25 87.8 1.6 2.8 2 0 0 2 2 2 1 DIL domain IQ PF00612.27 AAS52274.1 - 6.9e-09 34.7 17.1 0.01 15.6 0.1 6.1 6 0 0 6 6 6 3 IQ calmodulin-binding motif Myosin_N PF02736.19 AAS52274.1 - 4.6e-05 23.2 0.2 0.00014 21.6 0.2 1.9 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain HOOK PF05622.12 AAS52274.1 - 0.00011 20.5 16.0 0.00024 19.4 16.0 1.5 1 0 0 1 1 1 1 HOOK protein Tup_N PF08581.10 AAS52274.1 - 0.0018 18.5 2.8 0.0018 18.5 2.8 4.6 4 1 0 4 4 3 1 Tup N-terminal AAA_22 PF13401.6 AAS52274.1 - 0.0027 18.0 0.7 0.011 16.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain HSF_DNA-bind PF00447.17 AAS52274.1 - 0.035 14.7 0.3 0.21 12.2 0.3 2.4 1 0 0 1 1 1 0 HSF-type DNA-binding Sigma54_activat PF00158.26 AAS52274.1 - 0.07 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 AAS52274.1 - 0.16 12.5 0.0 0.16 12.5 0.0 2.9 2 1 0 2 2 1 0 ABC transporter ADIP PF11559.8 AAS52274.1 - 0.21 11.7 26.9 0.015 15.4 7.8 3.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding AAA_16 PF13191.6 AAS52274.1 - 0.43 10.9 0.0 0.43 10.9 0.0 3.0 2 1 0 2 2 1 0 AAA ATPase domain DUF1664 PF07889.12 AAS52274.1 - 0.58 10.2 16.0 0.92 9.6 4.6 3.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1843 PF08898.10 AAS52274.1 - 0.59 10.7 2.4 1.7 9.2 0.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) Spc7 PF08317.11 AAS52274.1 - 0.65 8.8 27.0 0.023 13.6 9.3 2.7 1 1 1 2 2 2 0 Spc7 kinetochore protein AHH PF14412.6 AAS52274.1 - 1.1 9.3 4.7 1.3 9.2 2.0 2.3 2 0 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DivIC PF04977.15 AAS52274.1 - 2.6 7.9 28.7 0.79 9.5 1.1 5.3 4 2 1 5 5 4 0 Septum formation initiator Synaptobrevin PF00957.21 AAS52275.1 - 6.5e-32 109.2 1.1 7.4e-32 109.0 1.1 1.0 1 0 0 1 1 1 1 Synaptobrevin DUF3671 PF12420.8 AAS52275.1 - 0.035 14.2 0.0 0.044 13.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF4683 PF15735.5 AAS52276.2 - 0.041 13.5 0.7 0.066 12.8 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) DNApol_Exo PF18136.1 AAS52277.1 - 2.3e-94 315.7 0.0 4.1e-94 314.9 0.0 1.4 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain DNA_pol_A PF00476.20 AAS52277.1 - 5.1e-54 183.7 0.0 8.6e-54 183.0 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase family A DUF1454 PF07305.12 AAS52277.1 - 0.021 14.3 0.1 0.1 12.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1454) DNA_pol_B_2 PF03175.13 AAS52277.1 - 0.038 12.9 0.0 0.77 8.5 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral Mad3_BUB1_I PF08311.12 AAS52277.1 - 0.19 11.7 0.9 0.62 10.1 0.4 2.0 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 vATP-synt_E PF01991.18 AAS52278.2 - 4.2e-60 202.6 11.3 4.9e-60 202.4 11.3 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit dCache_3 PF14827.6 AAS52278.2 - 0.0051 16.5 1.0 0.0095 15.6 1.0 1.4 1 1 0 1 1 1 1 Double sensory domain of two-component sensor kinase Phlebovirus_NSM PF07246.11 AAS52278.2 - 1.2 8.5 6.7 1.9 7.8 6.7 1.3 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Folliculin PF11704.8 AAS52278.2 - 2.1 8.2 6.3 1.1 9.2 4.3 1.5 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Kinesin_assoc PF16183.5 AAS52278.2 - 2.1 8.4 8.1 1.4 9.0 5.7 1.8 1 1 1 2 2 2 0 Kinesin-associated CorA PF01544.18 AAS52279.1 - 1e-06 28.3 1.1 1.8e-06 27.5 1.1 1.3 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein SKIP_SNW PF02731.15 AAS52281.1 - 2.8e-55 186.4 9.4 2.8e-55 186.4 9.4 1.6 2 0 0 2 2 2 1 SKIP/SNW domain Asp-B-Hydro_N PF05279.11 AAS52281.1 - 5.4 7.0 13.9 0.42 10.6 8.9 1.8 2 0 0 2 2 2 0 Aspartyl beta-hydroxylase N-terminal region RNase_P_Rpp14 PF01900.19 AAS52282.1 - 6.2e-35 119.5 0.3 7.6e-35 119.3 0.3 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family tRNA-synt_2c PF01411.19 AAS52283.1 - 7.7e-225 747.6 0.8 1.5e-224 746.6 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 AAS52283.1 - 1.5e-19 69.8 0.4 3.6e-19 68.6 0.4 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 AAS52283.1 - 2.1e-14 54.1 3.0 5.6e-14 52.7 3.0 1.8 1 0 0 1 1 1 1 DHHA1 domain Halogen_Hydrol PF10112.9 AAS52283.1 - 0.21 11.6 2.2 2.4 8.2 1.5 2.3 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein Glyco_transf_24 PF18404.1 AAS52284.1 - 9.9e-27 94.0 0.5 1.6e-26 93.3 0.0 1.5 2 0 0 2 2 2 1 Glucosyltransferase 24 Thioredoxin_14 PF18402.1 AAS52284.1 - 2.8e-18 66.8 0.7 6.6e-16 59.0 0.0 3.8 3 1 0 4 4 4 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 AAS52284.1 - 1.3e-08 34.9 0.0 2.9e-08 33.8 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_13 PF18401.1 AAS52284.1 - 6.5e-08 32.6 0.1 1.7e-07 31.2 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin-like domain UDP-g_GGTase PF06427.11 AAS52284.1 - 0.011 15.9 0.0 0.024 14.8 0.0 1.6 1 0 0 1 1 1 0 UDP-glucose:Glycoprotein Glucosyltransferase Fungal_trans PF04082.18 AAS52285.2 - 2.9e-36 124.9 2.7 5e-36 124.1 2.7 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS52285.2 - 4.9e-08 33.0 11.5 9.9e-08 32.0 11.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SlyX PF04102.12 AAS52285.2 - 0.16 12.6 0.0 0.42 11.3 0.0 1.7 1 0 0 1 1 1 0 SlyX SR-25 PF10500.9 AAS52285.2 - 0.34 10.5 3.1 0.58 9.7 3.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SWIRM PF04433.17 AAS52286.2 - 1e-08 35.4 0.0 1.8e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 SWIRM domain Mis12 PF05859.12 AAS52287.1 - 5.3e-42 143.1 0.2 1.1e-41 142.1 0.2 1.5 1 0 0 1 1 1 1 Mis12 protein SPAM PF02090.15 AAS52287.1 - 0.12 12.2 1.9 0.74 9.6 0.1 2.2 2 0 0 2 2 2 0 Salmonella surface presentation of antigen gene type M protein PK PF00224.21 AAS52288.1 - 7.5e-170 564.4 0.6 9.5e-170 564.1 0.6 1.1 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain PK_C PF02887.16 AAS52288.1 - 3.3e-33 114.4 0.1 8.5e-33 113.1 0.1 1.8 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 AAS52288.1 - 2.5e-05 23.5 0.2 0.00011 21.4 0.1 1.9 1 1 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family IMS PF00817.20 AAS52289.1 - 4e-29 101.5 0.0 7.9e-29 100.6 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 AAS52289.1 - 1.8e-09 38.3 0.0 5.2e-09 36.8 0.0 1.7 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain BRCT_2 PF16589.5 AAS52289.1 - 8.1e-09 35.8 0.0 2.6e-08 34.2 0.0 1.9 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain REV1_C PF16727.5 AAS52289.1 - 4.9e-06 26.8 0.0 1.5e-05 25.3 0.0 1.8 1 0 0 1 1 1 1 DNA repair protein REV1 C-terminal domain BRCT PF00533.26 AAS52289.1 - 6.4e-06 26.5 0.0 1.7e-05 25.1 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 AAS52289.1 - 0.00059 19.7 0.2 0.0018 18.1 0.0 2.0 2 0 0 2 2 2 1 twin BRCT domain HHH PF00633.23 AAS52289.1 - 0.17 11.8 0.1 0.98 9.4 0.1 2.4 2 0 0 2 2 2 0 Helix-hairpin-helix motif HLH PF00010.26 AAS52290.1 - 3.6e-19 68.5 0.1 6.3e-19 67.7 0.1 1.4 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PTRF_SDPR PF15237.6 AAS52290.1 - 0.018 14.7 0.2 0.024 14.3 0.2 1.1 1 0 0 1 1 1 0 PTRF/SDPR family RdDM_RDM1 PF09187.10 AAS52290.1 - 0.06 13.4 0.1 0.094 12.8 0.1 1.4 1 0 0 1 1 1 0 RNA-directed DNA methylation 1 DUF778 PF05608.12 AAS52290.1 - 0.083 13.3 1.3 0.13 12.6 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF778) Protamine_P2 PF00841.19 AAS52290.1 - 0.089 13.3 0.9 0.14 12.6 0.9 1.2 1 0 0 1 1 1 0 Sperm histone P2 MMR_HSR1_Xtn PF16897.5 AAS52292.1 - 3.7e-38 129.8 0.0 7.5e-38 128.8 0.0 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 AAS52292.1 - 1.6e-21 76.1 0.0 2.9e-21 75.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 AAS52292.1 - 1.5e-19 70.2 0.0 3.4e-19 69.0 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS52292.1 - 7.1e-09 35.4 0.1 1.8e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 Ferrous iron transport protein B MeaB PF03308.16 AAS52292.1 - 0.01 14.8 0.1 0.025 13.6 0.2 1.6 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AAS52292.1 - 0.011 15.8 0.3 5.8 6.9 0.3 2.4 1 1 1 2 2 2 0 Dynamin family AAA_22 PF13401.6 AAS52292.1 - 0.028 14.7 0.0 11 6.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain Arf PF00025.21 AAS52292.1 - 0.14 11.6 0.1 2.3 7.6 0.0 2.1 2 0 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 AAS52293.2 - 2.9e-35 121.6 0.0 2.9e-35 121.6 0.0 2.5 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AAS52293.2 - 1.1e-20 73.7 0.0 3.2e-20 72.2 0.0 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 AAS52293.2 - 6.6e-14 52.1 0.7 6.4e-09 36.1 0.0 3.2 2 0 0 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS52293.2 - 9.7e-08 32.1 0.1 5.5e-06 26.4 0.0 3.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase GTP_EFTU_D4 PF14578.6 AAS52293.2 - 2.8e-06 27.1 0.4 8.8e-06 25.5 0.4 1.9 1 1 0 1 1 1 1 Elongation factor Tu domain 4 Roc PF08477.13 AAS52293.2 - 0.00032 20.9 0.0 0.0013 19.0 0.0 2.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 AAS52293.2 - 0.011 15.3 0.0 0.083 12.4 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 AAS52293.2 - 0.033 14.0 0.0 0.033 14.0 0.0 2.5 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein TFIIA PF03153.13 AAS52293.2 - 3.9 7.4 38.4 8.7 6.2 38.4 1.6 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rpb1_5 PF04998.17 AAS52294.2 - 6.5e-98 327.4 10.9 5.9e-68 229.2 0.5 3.2 3 0 0 3 3 3 2 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AAS52294.2 - 4.9e-70 235.1 1.7 2.4e-69 232.8 0.2 2.4 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AAS52294.2 - 3.6e-39 134.2 2.1 8.8e-38 129.7 0.0 3.5 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_1 PF04997.12 AAS52294.2 - 1.3e-25 90.4 0.3 1.3e-25 90.4 0.3 3.1 4 0 0 4 4 4 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_4 PF05000.17 AAS52294.2 - 3.5e-24 84.8 0.0 1.8e-23 82.5 0.0 2.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Fungal_trans PF04082.18 AAS52295.2 - 3.8e-09 35.9 0.5 8.5e-09 34.8 0.1 1.7 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS52295.2 - 0.00017 21.7 9.1 0.00037 20.5 9.1 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RPA43_OB PF17875.1 AAS52297.1 - 1.1e-28 100.3 0.1 1.1e-28 100.3 0.1 1.8 2 0 0 2 2 2 1 RPA43 OB domain in RNA Pol I SHS2_Rpb7-N PF03876.17 AAS52297.1 - 4.6e-13 49.3 0.0 7.8e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 ACAS_N PF16177.5 AAS52298.1 - 0.03 14.3 0.1 0.067 13.1 0.1 1.6 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Pkinase PF00069.25 AAS52299.2 - 7.2e-55 186.2 0.0 1.1e-54 185.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52299.2 - 1.8e-32 112.6 0.0 3.4e-32 111.7 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AAS52299.2 - 3.2e-19 69.1 0.1 1.1e-18 67.3 0.0 2.0 2 0 0 2 2 2 1 FHA domain Pkinase_fungal PF17667.1 AAS52299.2 - 3.2e-06 26.2 0.0 5.6e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Yop-YscD_cpl PF16697.5 AAS52299.2 - 0.0001 22.5 0.0 0.00023 21.4 0.0 1.6 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Kdo PF06293.14 AAS52299.2 - 0.0016 17.8 0.0 0.0025 17.2 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AAS52299.2 - 0.0096 15.3 0.0 0.015 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AAS52299.2 - 0.077 11.9 0.0 0.11 11.4 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 AAS52299.2 - 0.12 12.3 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family TFB6 PF17110.5 AAS52300.1 - 1.2e-34 119.6 0.4 4.6e-30 104.6 0.0 3.0 2 1 1 3 3 3 2 Subunit 11 of the general transcription factor TFIIH SOG2 PF10428.9 AAS52301.2 - 5.2e-127 425.1 20.6 1.5e-126 423.6 20.6 1.7 1 1 0 1 1 1 1 RAM signalling pathway protein LRR_8 PF13855.6 AAS52301.2 - 9.5e-16 57.3 10.4 6.2e-09 35.5 2.3 3.1 3 0 0 3 3 3 2 Leucine rich repeat LRR_4 PF12799.7 AAS52301.2 - 1.5e-15 57.0 8.5 2e-07 31.2 0.1 4.5 3 1 1 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 AAS52301.2 - 0.00063 19.3 1.3 0.0025 17.3 0.1 2.2 2 0 0 2 2 2 1 Leucine-rich repeat LRR_6 PF13516.6 AAS52301.2 - 0.023 14.7 12.0 0.35 11.0 0.0 5.8 6 0 0 6 6 6 0 Leucine Rich repeat Cbl_N PF02262.16 AAS52301.2 - 0.1 12.6 0.5 0.52 10.3 0.1 2.3 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 LRR_1 PF00560.33 AAS52301.2 - 3.7 8.5 13.0 17 6.4 0.1 6.1 7 0 0 7 7 7 0 Leucine Rich Repeat Cyto_heme_lyase PF01265.17 AAS52302.1 - 3e-96 322.5 3.8 1.2e-95 320.5 3.8 1.8 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase HsdM_N PF12161.8 AAS52303.2 - 0.038 14.6 0.2 0.22 12.2 0.0 2.4 2 0 0 2 2 2 0 HsdM N-terminal domain YqeY PF09424.10 AAS52303.2 - 0.094 12.8 0.1 1.3 9.0 0.2 2.8 2 1 1 3 3 3 0 Yqey-like protein Cyclin_N PF00134.23 AAS52304.2 - 5.6e-31 106.9 0.8 8.9e-31 106.3 0.8 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cupin_8 PF13621.6 AAS52305.1 - 4.3e-38 131.5 0.0 1.7e-36 126.3 0.0 2.2 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 AAS52305.1 - 0.095 13.1 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 JmjC domain, hydroxylase ETF_QO PF05187.13 AAS52307.2 - 1.6e-44 150.3 0.3 2.6e-44 149.6 0.3 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 AAS52307.2 - 4.9e-10 39.5 0.1 1.9e-05 24.5 0.1 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AAS52307.2 - 1.2e-06 27.9 1.3 0.0059 15.7 0.6 2.2 2 0 0 2 2 2 2 FAD binding domain NAD_binding_8 PF13450.6 AAS52307.2 - 7.4e-06 26.1 0.1 2.6e-05 24.4 0.1 2.0 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AAS52307.2 - 1.7e-05 24.2 0.0 0.00017 21.0 0.0 2.1 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS52307.2 - 0.00014 21.2 0.1 0.16 11.2 0.2 2.2 2 0 0 2 2 2 2 Thi4 family HI0933_like PF03486.14 AAS52307.2 - 0.00052 18.8 0.5 0.0022 16.8 0.3 1.9 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.19 AAS52307.2 - 0.00083 18.7 0.2 0.0035 16.6 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain Pyr_redox_3 PF13738.6 AAS52307.2 - 0.0013 18.0 0.2 0.0022 17.3 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AAS52307.2 - 0.0088 16.0 0.1 0.02 14.9 0.1 1.5 1 0 0 1 1 1 1 FAD-NAD(P)-binding Fer4_7 PF12838.7 AAS52307.2 - 0.011 16.4 0.5 0.03 14.9 0.5 1.8 1 0 0 1 1 1 0 4Fe-4S dicluster domain Pyr_redox PF00070.27 AAS52307.2 - 0.017 15.6 0.2 5 7.7 0.0 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AAS52307.2 - 0.048 13.0 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AAS52307.2 - 0.059 12.4 0.2 0.086 11.9 0.2 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Fer4_2 PF12797.7 AAS52307.2 - 0.11 12.6 0.5 0.31 11.2 0.5 1.7 1 0 0 1 1 1 0 4Fe-4S binding domain CDC24 PF06395.11 AAS52308.1 - 9.4e-36 122.0 0.4 3.5e-35 120.1 0.4 2.1 1 0 0 1 1 1 1 CDC24 Calponin RhoGEF PF00621.20 AAS52308.1 - 5.8e-34 117.9 4.2 5.8e-34 117.9 4.2 2.1 2 0 0 2 2 2 1 RhoGEF domain PH_10 PF15411.6 AAS52308.1 - 5.9e-31 107.3 0.5 1.4e-30 106.1 0.5 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PB1 PF00564.24 AAS52308.1 - 9.5e-07 28.7 0.4 3.1e-06 27.0 0.4 1.9 1 0 0 1 1 1 1 PB1 domain PH PF00169.29 AAS52308.1 - 0.16 12.5 2.5 1.4 9.5 2.5 2.6 1 1 0 1 1 1 0 PH domain COPIIcoated_ERV PF07970.12 AAS52309.1 - 1.4e-67 227.7 0.0 1.7e-67 227.5 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AAS52309.1 - 1.2e-27 96.1 0.0 2.3e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) PX PF00787.24 AAS52310.2 - 5.5e-22 77.9 0.0 7e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 PX domain Histone PF00125.24 AAS52311.1 - 1.3e-24 87.0 0.0 1.5e-24 86.8 0.0 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AAS52311.1 - 1.9e-22 79.3 2.1 2.6e-22 78.9 2.1 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAFII28 PF04719.14 AAS52311.1 - 0.0075 16.3 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 hTAFII28-like protein conserved region CENP-X PF09415.10 AAS52311.1 - 0.011 16.0 0.3 0.019 15.3 0.3 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF3791 PF12668.7 AAS52311.1 - 0.033 14.2 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3791) ISP3_C PF18045.1 AAS52311.1 - 0.047 13.6 0.2 1.8 8.5 0.0 2.1 1 1 1 2 2 2 0 ISP3 C-terminal TAF PF02969.17 AAS52311.1 - 0.088 13.0 0.2 0.16 12.2 0.2 1.5 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) DUF3453 PF11935.8 AAS52312.1 - 1.5e-48 165.4 0.0 2.4e-48 164.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3453) GGDEF_2 PF17853.1 AAS52312.1 - 0.00075 19.7 0.2 0.033 14.4 0.1 2.6 2 0 0 2 2 2 1 GGDEF-like domain SAM_2 PF07647.17 AAS52313.2 - 2.9e-06 27.3 0.0 6.4e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 AAS52313.2 - 4.1e-06 27.1 0.2 1.1e-05 25.8 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) PDEase_I PF00233.19 AAS52314.2 - 1.8e-49 168.7 0.0 2.5e-49 168.1 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GCV_H PF01597.19 AAS52315.2 - 9e-40 135.4 0.0 1.1e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 Glycine cleavage H-protein BolA PF01722.18 AAS52316.1 - 2.3e-25 88.6 0.8 2.9e-25 88.3 0.8 1.1 1 0 0 1 1 1 1 BolA-like protein BolA PF01722.18 AAS52317.1 - 5.9e-12 45.7 0.0 2e-11 44.0 0.0 1.9 1 1 0 1 1 1 1 BolA-like protein eIF2A PF08662.11 AAS52318.1 - 1.4e-28 100.2 2.2 1.3e-23 83.9 1.5 4.4 2 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A RRM_1 PF00076.22 AAS52318.1 - 2e-09 37.1 0.0 4.8e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PALB2_WD40 PF16756.5 AAS52318.1 - 0.064 12.2 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain BSD PF03909.17 AAS52319.2 - 0.00088 19.2 3.4 0.0025 17.8 1.0 3.2 2 0 0 2 2 2 1 BSD domain TUSC2 PF15000.6 AAS52319.2 - 0.011 16.0 0.6 0.038 14.3 0.6 1.9 1 0 0 1 1 1 0 Tumour suppressor candidate 2 MqsA_antitoxin PF15731.5 AAS52319.2 - 0.32 11.1 4.2 0.25 11.4 0.8 2.6 3 1 0 3 3 3 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA DUF4407 PF14362.6 AAS52319.2 - 6.2 6.1 36.5 7.1 5.9 2.5 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 AAS52319.2 - 6.6 6.9 64.7 0.55 10.4 21.8 5.8 4 3 1 5 5 5 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 AAS52319.2 - 9 6.8 56.2 0.18 12.3 5.3 7.4 4 2 2 6 6 6 0 Cell division protein ZapB Proteasome PF00227.26 AAS52320.1 - 3.1e-51 173.6 0.0 3.9e-51 173.3 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS52320.1 - 5.2e-12 45.2 1.0 5.9e-12 45.0 0.0 1.6 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature EF_assoc_2 PF08356.12 AAS52321.1 - 2.6e-26 91.4 0.0 6.4e-26 90.2 0.0 1.8 1 0 0 1 1 1 1 EF hand associated EF_assoc_1 PF08355.12 AAS52321.1 - 4.3e-26 90.3 0.8 9.7e-26 89.2 0.8 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 AAS52321.1 - 2e-23 82.8 0.0 4.1e-11 42.7 0.0 2.7 2 1 0 2 2 2 2 Ras family Roc PF08477.13 AAS52321.1 - 1.1e-14 54.7 0.0 5.9e-06 26.5 0.0 3.1 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AAS52321.1 - 6.4e-09 35.9 0.0 0.0028 17.7 0.0 3.0 2 1 0 2 2 2 2 50S ribosome-binding GTPase EF-hand_1 PF00036.32 AAS52321.1 - 1.5e-07 30.5 3.0 0.0027 17.1 0.8 3.0 3 0 0 3 3 2 2 EF hand Dynamin_N PF00350.23 AAS52321.1 - 2.2e-06 27.8 0.1 0.074 13.1 0.0 2.5 2 1 0 2 2 2 2 Dynamin family EF-hand_7 PF13499.6 AAS52321.1 - 5.4e-06 26.8 0.2 0.058 13.8 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS52321.1 - 2.7e-05 23.7 3.8 0.013 15.4 0.8 3.0 2 0 0 2 2 2 2 EF-hand domain AAA_16 PF13191.6 AAS52321.1 - 0.00094 19.6 0.0 0.65 10.4 0.0 2.9 3 1 0 3 3 2 1 AAA ATPase domain AAA_29 PF13555.6 AAS52321.1 - 0.005 16.5 0.0 4.8 7.0 0.0 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AAS52321.1 - 0.007 16.6 0.0 0.7 10.2 0.0 2.8 2 1 0 2 2 2 1 AAA domain EF-hand_5 PF13202.6 AAS52321.1 - 0.0084 15.6 1.5 0.0084 15.6 1.5 2.0 2 0 0 2 2 2 1 EF hand ABC_tran PF00005.27 AAS52321.1 - 0.0094 16.5 0.0 2.8 8.5 0.0 2.4 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 AAS52321.1 - 0.0098 15.8 0.1 0.14 12.0 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_24 PF13479.6 AAS52321.1 - 0.012 15.3 0.0 2.9 7.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 AAS52321.1 - 0.021 15.2 0.0 4.6 7.7 0.0 2.7 2 1 0 2 2 2 0 RNA helicase Arf PF00025.21 AAS52321.1 - 0.023 14.1 0.0 0.23 10.9 0.0 2.3 2 0 0 2 2 2 0 ADP-ribosylation factor family TniB PF05621.11 AAS52321.1 - 0.042 13.3 0.0 0.3 10.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein GTP_EFTU PF00009.27 AAS52321.1 - 0.044 13.3 0.0 17 4.9 0.0 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 AAS52321.1 - 0.058 12.9 0.0 4.6 6.8 0.0 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B Septin PF00735.18 AAS52321.1 - 0.064 12.5 0.0 0.38 10.0 0.0 2.1 2 0 0 2 2 2 0 Septin EF-hand_8 PF13833.6 AAS52321.1 - 0.097 12.5 0.6 3.2 7.7 0.8 2.6 2 0 0 2 2 2 0 EF-hand domain pair AAA_18 PF13238.6 AAS52321.1 - 0.18 12.4 0.0 6 7.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain Zn_clus PF00172.18 AAS52322.2 - 7.1e-11 42.0 15.2 1.5e-10 41.0 15.2 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans PF04082.18 AAS52322.2 - 0.00081 18.5 1.0 0.27 10.2 0.0 3.2 3 0 0 3 3 3 2 Fungal specific transcription factor domain GDPD PF03009.17 AAS52322.2 - 0.037 13.7 1.1 0.081 12.6 0.2 2.0 2 0 0 2 2 2 0 Glycerophosphoryl diester phosphodiesterase family Rsbr_N PF08678.10 AAS52322.2 - 0.19 11.8 4.8 20 5.3 0.0 3.7 2 1 1 3 3 3 0 Rsbr N terminal Zn_clus PF00172.18 AAS52323.1 - 7.3e-09 35.6 8.9 1.5e-08 34.6 8.9 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Zn_clus PF00172.18 AAS52324.1 - 2.9e-09 36.9 10.8 5.5e-09 36.0 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Pex24p PF06398.11 AAS52324.1 - 0.0037 16.3 2.4 0.0098 14.9 2.4 1.6 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin DLH PF01738.18 AAS52325.1 - 2.4e-33 115.5 0.3 2.9e-33 115.3 0.3 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family LisH_2 PF16045.5 AAS52325.1 - 0.097 11.7 0.0 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 LisH Rbx_binding PF18113.1 AAS52325.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain TRP PF06011.12 AAS52326.2 - 4.7e-149 496.7 31.6 6e-149 496.4 31.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 AAS52326.2 - 1.2e-37 129.3 0.4 2.1e-37 128.6 0.4 1.4 1 0 0 1 1 1 1 ML-like domain HemY_N PF07219.13 AAS52326.2 - 2.8 8.2 10.3 6.7 7.0 0.8 3.6 3 0 0 3 3 3 0 HemY protein N-terminus AMP-binding PF00501.28 AAS52327.1 - 2.9e-87 293.0 0.0 3.5e-87 292.7 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AAS52327.1 - 1.6e-22 80.3 0.1 3.5e-22 79.2 0.1 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AAS52327.1 - 7.8e-17 60.9 0.2 3.4e-16 58.9 0.1 2.1 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus CH PF00307.31 AAS52328.2 - 2.4e-14 53.4 0.0 3.2e-14 53.0 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain Peroxin-22 PF12827.7 AAS52329.1 - 3.6e-22 78.4 0.0 4.3e-22 78.2 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family Glyco_transf_4 PF13439.6 AAS52329.1 - 0.21 11.6 1.0 33 4.4 0.0 2.8 1 1 2 3 3 3 0 Glycosyltransferase Family 4 Rad1 PF02144.16 AAS52330.1 - 1.2e-66 224.6 0.0 1.5e-66 224.3 0.0 1.1 1 0 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Ribosomal_L7Ae PF01248.26 AAS52331.1 - 4.8e-23 80.7 0.2 5.9e-23 80.4 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF1269 PF06897.12 AAS52331.1 - 0.086 13.1 0.1 0.16 12.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1269) GDI PF00996.18 AAS52332.2 - 5.1e-43 147.2 0.0 2e-42 145.3 0.0 1.7 1 1 0 1 1 1 1 GDP dissociation inhibitor Kelch_5 PF13854.6 AAS52333.1 - 1.8e-10 40.5 4.7 0.046 13.7 0.0 6.6 7 0 0 7 7 7 4 Kelch motif Kelch_4 PF13418.6 AAS52333.1 - 1.8e-09 37.4 2.6 0.00015 21.7 0.1 5.2 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_6 PF13964.6 AAS52333.1 - 1.2e-06 28.6 5.0 0.37 11.2 0.1 5.8 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 AAS52333.1 - 3.8e-05 23.9 3.9 0.38 11.1 0.0 5.4 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 AAS52333.1 - 4.4e-05 23.3 8.7 2 8.5 0.0 5.8 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 AAS52333.1 - 0.00021 20.8 2.6 0.97 9.1 0.3 4.3 4 0 0 4 4 4 2 Kelch motif LRR_4 PF12799.7 AAS52335.1 - 4.9e-17 61.7 36.2 8.7e-05 22.8 0.1 8.7 5 2 5 10 10 10 7 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AAS52335.1 - 1.7e-13 50.1 29.7 2.3e-05 24.1 1.3 6.5 3 1 5 8 8 8 6 Leucine rich repeat LRR_6 PF13516.6 AAS52335.1 - 2.1e-10 39.8 21.4 0.47 10.6 0.0 9.3 9 0 0 9 9 9 4 Leucine Rich repeat LRR_9 PF14580.6 AAS52335.1 - 4.7e-06 26.2 4.9 0.0076 15.8 0.2 3.8 2 1 0 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 AAS52335.1 - 0.076 13.6 38.0 4.5 8.2 3.1 10.4 9 3 0 9 9 9 0 Leucine Rich Repeat Aldedh PF00171.22 AAS52336.2 - 1.2e-178 594.4 0.3 1.3e-178 594.3 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 AAS52336.2 - 0.07 12.6 0.1 11 5.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1487) Alb1 PF09135.11 AAS52338.1 - 2.5e-26 92.6 14.7 3.8e-26 92.0 14.7 1.3 1 0 0 1 1 1 1 Alb1 AviRa PF11599.8 AAS52338.1 - 0.1 12.0 1.2 0.14 11.6 1.2 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa DUF2201_N PF13203.6 AAS52338.1 - 0.29 10.7 4.7 0.36 10.4 4.7 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Mannosyl_trans3 PF11051.8 AAS52339.1 - 6.8e-68 229.0 0.0 9.5e-68 228.5 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 AAS52339.1 - 0.0073 15.9 0.1 0.018 14.6 0.0 1.6 2 0 0 2 2 2 1 Glycosyl transferase family 8 DUF1828 PF08861.10 AAS52339.1 - 0.052 13.8 0.0 0.46 10.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function DUF1828 Sds3 PF08598.11 AAS52340.2 - 2.1e-48 165.2 0.4 2.1e-48 165.2 0.4 1.8 2 1 0 2 2 2 1 Sds3-like Ribosomal_S19 PF00203.21 AAS52341.1 - 9.3e-35 118.4 0.2 1.6e-34 117.6 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein S19 Ribosomal_60s PF00428.19 AAS52342.1 - 1.9e-24 86.1 13.4 2.4e-24 85.7 13.4 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Phage_lysis PF03245.13 AAS52342.1 - 0.16 12.1 2.0 0.22 11.7 1.7 1.3 1 1 0 1 1 1 0 Bacteriophage Rz lysis protein UBA_6 PF18039.1 AAS52342.1 - 0.28 11.1 1.0 1.5 8.8 1.0 2.0 1 1 0 1 1 1 0 UBA-like domain Cys_Met_Meta_PP PF01053.20 AAS52343.1 - 3.4e-144 480.1 0.0 3.9e-144 479.9 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Met_gamma_lyase PF06838.11 AAS52343.1 - 9.4e-06 24.4 0.0 1.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Methionine gamma-lyase Aminotran_1_2 PF00155.21 AAS52343.1 - 0.00013 21.2 0.0 0.00021 20.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AAS52343.1 - 0.015 14.2 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Aminotransferase class-V SIL1 PF16782.5 AAS52344.1 - 4.2e-94 315.0 0.7 5e-94 314.8 0.7 1.0 1 0 0 1 1 1 1 Nucleotide exchange factor SIL1 DUF775 PF05603.12 AAS52345.1 - 1.9e-61 207.1 0.3 2.2e-61 206.9 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF775) tRNA-synt_1c PF00749.21 AAS52346.1 - 1.2e-108 362.7 0.0 1.5e-108 362.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain HTH_ABP1_N PF18107.1 AAS52346.1 - 0.089 12.5 0.1 7.1 6.4 0.0 2.6 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain SMC_N PF02463.19 AAS52347.2 - 7.3e-22 77.9 16.6 9e-21 74.3 16.6 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AAS52347.2 - 5.3e-18 66.2 11.5 5.3e-18 66.2 11.5 5.4 2 2 2 4 4 3 1 AAA domain AAA_15 PF13175.6 AAS52347.2 - 1.5e-10 41.4 0.6 1.5e-10 41.4 0.6 3.3 2 2 0 2 2 1 1 AAA ATPase domain AAA_29 PF13555.6 AAS52347.2 - 1.3e-05 24.8 0.0 2.6e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Leu_zip PF15294.6 AAS52347.2 - 0.004 16.7 12.4 0.004 16.7 12.4 4.5 2 2 2 4 4 4 1 Leucine zipper GAS PF13851.6 AAS52347.2 - 0.0061 15.9 13.9 0.0061 15.9 13.9 5.6 2 2 3 6 6 6 2 Growth-arrest specific micro-tubule binding AAA_21 PF13304.6 AAS52347.2 - 0.0086 15.9 0.1 0.0086 15.9 0.1 3.3 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AAS52347.2 - 0.034 14.1 2.6 0.069 13.1 0.0 2.6 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 AAS52347.2 - 0.043 14.3 0.0 0.043 14.3 0.0 5.3 3 2 0 4 4 3 0 ABC transporter Fucosidase_C PF16757.5 AAS52347.2 - 0.09 13.3 0.3 0.36 11.4 0.3 2.1 1 0 0 1 1 1 0 Alpha-L-fucosidase C-terminal domain AAA_25 PF13481.6 AAS52347.2 - 0.11 12.1 2.3 0.2 11.2 0.0 2.6 3 0 0 3 3 3 0 AAA domain MDM10 PF12519.8 AAS52349.2 - 1.1e-139 466.3 1.3 1.4e-139 466.0 1.3 1.1 1 0 0 1 1 1 1 Mitochondrial distribution and morphology protein 10 Porin_3 PF01459.22 AAS52349.2 - 0.079 12.4 0.0 0.28 10.6 0.0 1.8 2 1 0 2 2 2 0 Eukaryotic porin Spo7 PF03907.13 AAS52350.1 - 2.5e-70 236.4 4.5 3.5e-70 235.9 4.5 1.2 1 0 0 1 1 1 1 Spo7-like protein OPT PF03169.15 AAS52350.1 - 0.0025 16.5 0.0 0.0034 16.1 0.0 1.1 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF1673 PF07895.11 AAS52350.1 - 0.11 12.2 0.6 0.15 11.7 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) B56 PF01603.20 AAS52351.2 - 2.5e-174 580.1 9.1 3.6e-174 579.6 9.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) FUN14 PF04930.15 AAS52352.1 - 6.7e-08 32.8 2.6 6.7e-08 32.8 2.6 2.0 2 1 0 2 2 2 1 FUN14 family zf-CCCH PF00642.24 AAS52353.1 - 1e-12 47.6 30.6 0.00069 19.5 0.5 5.5 4 2 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AAS52353.1 - 6.6e-12 45.1 35.9 6.5e-06 26.0 2.5 5.7 6 0 0 6 6 6 5 Zinc finger domain Torus PF16131.5 AAS52353.1 - 6.8e-10 39.6 22.9 0.0025 18.5 0.4 5.0 1 1 4 5 5 5 3 Torus domain zf-CCCH_3 PF15663.5 AAS52353.1 - 2.3e-05 24.5 7.6 2.3e-05 24.5 7.6 2.3 1 1 1 2 2 2 1 Zinc-finger containing family zf-CCCH_4 PF18044.1 AAS52353.1 - 0.029 14.2 1.3 0.029 14.2 1.3 5.0 5 3 0 5 5 5 0 CCCH-type zinc finger Nab2p_Zf1 PF18260.1 AAS52353.1 - 2.3 8.2 21.6 1.7 8.6 0.2 4.3 4 0 0 4 4 4 0 Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1 Pkinase PF00069.25 AAS52354.2 - 1.9e-19 70.1 0.0 2.4e-19 69.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52354.2 - 1.2e-07 31.3 0.0 1.6e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AAS52354.2 - 0.0024 17.9 7.4 0.0026 17.7 5.0 2.4 2 1 0 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 AAS52354.2 - 0.076 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Pil1 PF13805.6 AAS52355.1 - 3.4e-124 413.6 0.1 4.2e-124 413.3 0.1 1.1 1 0 0 1 1 1 1 Eisosome component PIL1 COG4 PF08318.12 AAS52356.1 - 3.3e-85 286.1 0.7 6.9e-85 285.1 0.7 1.6 1 0 0 1 1 1 1 COG4 transport protein UvrD-helicase PF00580.21 AAS52356.1 - 0.033 13.7 5.8 0.063 12.8 5.8 1.3 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Vps54_N PF10475.9 AAS52356.1 - 0.94 8.7 8.5 2.4 7.3 8.5 1.6 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex HIP1_clath_bdg PF16515.5 AAS52356.1 - 1.1 9.9 8.6 2.9 8.5 8.6 1.7 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DASH_Dad3 PF08656.10 AAS52356.1 - 3 8.0 8.3 8.8 6.5 0.2 3.1 1 1 1 2 2 2 0 DASH complex subunit Dad3 Forkhead PF00250.18 AAS52357.2 - 1e-25 89.8 0.1 2.7e-25 88.4 0.1 1.7 1 0 0 1 1 1 1 Forkhead domain FHA PF00498.26 AAS52357.2 - 1.4e-11 44.6 0.1 2.9e-11 43.5 0.1 1.6 1 0 0 1 1 1 1 FHA domain TFIIA PF03153.13 AAS52357.2 - 0.00072 19.7 35.8 0.00072 19.7 35.8 3.2 2 1 1 3 3 3 1 Transcription factor IIA, alpha/beta subunit Proteasome PF00227.26 AAS52358.2 - 2.6e-47 160.8 0.1 3.2e-47 160.5 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Ribosomal_L5_C PF00673.21 AAS52359.1 - 1.4e-21 76.4 0.0 2.1e-21 75.9 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AAS52359.1 - 1.9e-19 69.7 0.0 5e-19 68.4 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L5 HTH_ABP1_N PF18107.1 AAS52359.1 - 0.0088 15.7 0.1 0.018 14.8 0.1 1.5 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain BCAS2 PF05700.11 AAS52360.1 - 2.3e-11 43.8 9.3 3e-07 30.3 6.6 2.1 2 0 0 2 2 2 2 Breast carcinoma amplified sequence 2 (BCAS2) FliD_C PF07195.12 AAS52360.1 - 0.076 12.4 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus L51_S25_CI-B8 PF05047.16 AAS52360.1 - 0.087 12.8 0.0 1.2 9.2 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain KfrA_N PF11740.8 AAS52360.1 - 0.6 10.8 12.7 5.4 7.7 8.9 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term IF-2B PF01008.17 AAS52362.1 - 7.9e-100 333.7 0.1 1.3e-99 332.9 0.1 1.4 1 0 0 1 1 1 1 Initiation factor 2 subunit family SET PF00856.28 AAS52362.1 - 0.082 13.3 2.9 4.4 7.7 1.4 2.6 2 1 0 2 2 2 0 SET domain SOBP PF15279.6 AAS52362.1 - 0.4 11.3 11.8 4.9 7.7 8.4 2.3 2 0 0 2 2 2 0 Sine oculis-binding protein XPG_I PF00867.18 AAS52362.1 - 1.4 9.3 7.6 7.1 7.1 0.1 3.5 2 1 1 3 3 3 0 XPG I-region L51_S25_CI-B8 PF05047.16 AAS52363.1 - 1.6e-12 47.1 0.0 2.7e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain DUF3818 PF12825.7 AAS52364.1 - 4.2e-112 374.5 10.2 9.3e-112 373.4 10.2 1.6 1 0 0 1 1 1 1 Domain of unknown function in PX-proteins (DUF3818) PXB PF12828.7 AAS52364.1 - 1.3e-39 135.1 0.2 3.2e-39 133.9 0.2 1.7 1 0 0 1 1 1 1 PX-associated PX PF00787.24 AAS52364.1 - 2.9e-07 30.5 0.1 3.1e-06 27.1 0.0 2.7 2 1 0 2 2 2 1 PX domain Peptidase_C65 PF10275.9 AAS52364.1 - 0.012 15.1 2.6 0.013 15.0 0.1 2.2 2 0 0 2 2 2 0 Peptidase C65 Otubain SLX9 PF15341.6 AAS52365.1 - 3.8e-23 82.3 4.9 3.8e-23 82.3 4.9 1.7 2 0 0 2 2 2 1 Ribosome biogenesis protein SLX9 DUF3486 PF11985.8 AAS52365.1 - 0.00083 19.8 1.0 0.0013 19.1 0.6 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3486) SelB-wing_2 PF09106.11 AAS52365.1 - 0.044 14.0 0.8 0.75 10.0 0.3 2.4 2 0 0 2 2 2 0 Elongation factor SelB, winged helix MAS20 PF02064.15 AAS52366.1 - 6.1e-35 120.1 1.2 7.9e-35 119.8 1.2 1.1 1 0 0 1 1 1 1 MAS20 protein import receptor DUF4149 PF13664.6 AAS52367.2 - 8.6e-17 61.3 1.0 8.6e-17 61.3 1.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Peptidase_M22 PF00814.25 AAS52368.1 - 3.4e-84 282.7 0.0 4.2e-84 282.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 AAS52368.1 - 0.024 14.3 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus DASH_Spc34 PF08657.10 AAS52369.1 - 4.3e-86 288.8 1.8 4.9e-86 288.7 1.8 1.0 1 0 0 1 1 1 1 DASH complex subunit Spc34 ATG16 PF08614.11 AAS52369.1 - 0.18 12.0 5.5 0.24 11.6 4.2 1.7 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) WD40 PF00400.32 AAS52370.1 - 1.9e-31 107.6 6.4 2.6e-06 28.1 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52370.1 - 4.2e-11 43.0 0.1 0.02 15.2 0.0 5.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS52370.1 - 2.5e-07 29.8 6.4 0.032 12.9 0.1 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 AAS52370.1 - 3.8e-06 26.9 0.4 0.00032 20.7 0.0 3.3 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 AAS52370.1 - 4.6e-05 22.9 0.3 0.00032 20.1 0.0 2.3 2 1 1 3 3 3 1 WD40-like domain Caf4 PF11615.8 AAS52370.1 - 0.00044 20.2 0.1 1.3 9.1 0.1 2.7 1 1 1 2 2 2 2 CCR4-associated factor 4 Mdv1 PF11542.8 AAS52370.1 - 0.0011 18.9 0.1 0.0025 17.8 0.1 1.6 1 0 0 1 1 1 1 Mitochondrial division protein 1 COX6B PF02297.17 AAS52371.1 - 2.1e-23 82.3 2.8 2.6e-23 82.0 2.8 1.1 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb zf-RING_2 PF13639.6 AAS52371.1 - 0.034 14.5 0.3 0.075 13.4 0.3 1.7 1 1 0 1 1 1 0 Ring finger domain FANCL_C PF11793.8 AAS52371.1 - 0.044 14.0 0.1 0.073 13.2 0.1 1.4 1 0 0 1 1 1 0 FANCL C-terminal domain zf-rbx1 PF12678.7 AAS52371.1 - 0.066 13.5 0.4 0.096 13.0 0.4 1.4 1 1 0 1 1 1 0 RING-H2 zinc finger domain Herpes_UL32 PF06070.11 AAS52371.1 - 0.093 10.5 0.0 0.11 10.3 0.0 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Pet191_N PF10203.9 AAS52371.1 - 0.16 12.3 2.7 2.6 8.4 0.2 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 SUN PF03856.13 AAS52372.1 - 1.2e-82 277.1 11.6 1.4e-82 276.8 11.6 1.0 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) DUF333 PF03891.15 AAS52372.1 - 0.053 13.7 0.7 2.4 8.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF333) SRAP PF02586.14 AAS52373.1 - 2.5e-60 203.8 0.3 2.9e-60 203.5 0.3 1.1 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) DUF3660 PF12398.8 AAS52373.1 - 0.078 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Receptor serine/threonine kinase Mur_ligase_M PF08245.12 AAS52374.1 - 1.5e-06 28.4 0.6 6.6e-05 23.0 0.6 2.4 1 1 0 1 1 1 1 Mur ligase middle domain Mur_ligase_C PF02875.21 AAS52374.1 - 0.0056 16.9 0.0 0.018 15.2 0.0 1.9 2 0 0 2 2 2 1 Mur ligase family, glutamate ligase domain Med11 PF10280.9 AAS52375.2 - 5.4e-09 36.6 0.5 9.1e-09 35.9 0.5 1.5 1 1 0 1 1 1 1 Mediator complex protein CM_2 PF01817.21 AAS52375.2 - 0.0031 17.8 0.2 0.0084 16.4 0.2 1.7 1 1 1 2 2 2 1 Chorismate mutase type II PI3K_P85_iSH2 PF16454.5 AAS52375.2 - 0.049 13.2 0.5 0.39 10.3 0.1 2.2 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain YdaT_toxin PF06254.11 AAS52375.2 - 0.074 13.6 0.0 0.22 12.1 0.0 1.7 2 0 0 2 2 2 0 Putative bacterial toxin ydaT DASH_Dad3 PF08656.10 AAS52375.2 - 0.12 12.5 0.3 0.28 11.3 0.3 1.7 1 1 0 1 1 1 0 DASH complex subunit Dad3 GCR1_C PF12550.8 AAS52376.1 - 9.3e-26 90.0 1.1 2.2e-25 88.8 1.1 1.7 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes STAT_alpha PF01017.20 AAS52376.1 - 0.02 14.8 4.2 0.043 13.7 4.2 1.6 1 0 0 1 1 1 0 STAT protein, all-alpha domain Seryl_tRNA_N PF02403.22 AAS52376.1 - 0.066 13.4 0.6 0.2 11.9 0.6 1.7 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain She2p PF11435.8 AAS52377.1 - 3.6e-83 278.2 10.7 4.7e-83 277.8 10.7 1.1 1 0 0 1 1 1 1 RNA binding protein She2p Myosin_head PF00063.21 AAS52378.2 - 1.9e-233 776.6 4.4 2.4e-233 776.3 4.4 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_TH1 PF06017.13 AAS52378.2 - 2.1e-47 161.3 0.0 3.4e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding SH3_1 PF00018.28 AAS52378.2 - 1.6e-09 37.2 0.0 3e-09 36.3 0.0 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS52378.2 - 7.6e-07 28.9 0.1 2.1e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 AAS52378.2 - 0.00031 20.4 0.0 0.00065 19.3 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain Hpr_kinase_C PF07475.12 AAS52378.2 - 0.024 14.2 0.1 8.9 5.8 0.0 2.5 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_16 PF13191.6 AAS52378.2 - 0.028 14.8 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AAS52378.2 - 0.033 14.5 0.0 0.13 12.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AAS52378.2 - 0.072 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 AAS52378.2 - 0.086 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Rad9_Rad53_bind PF08605.10 AAS52378.2 - 0.14 12.4 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Fungal Rad9-like Rad53-binding Zeta_toxin PF06414.12 AAS52378.2 - 0.27 10.5 0.9 0.95 8.7 0.0 2.3 3 0 0 3 3 3 0 Zeta toxin IQ PF00612.27 AAS52378.2 - 3.2 7.8 15.1 1.5 8.9 5.6 2.6 1 1 1 2 2 2 0 IQ calmodulin-binding motif TPP_enzyme_N PF02776.18 AAS52379.1 - 3e-56 189.7 0.3 1.4e-55 187.6 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AAS52379.1 - 8.1e-49 165.3 0.4 3.6e-47 160.0 0.1 2.9 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS52379.1 - 1.5e-39 134.8 0.4 4.1e-39 133.4 0.4 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain His_Phos_1 PF00300.22 AAS52380.1 - 3.7e-12 46.4 2.5 3.5e-11 43.2 2.5 2.3 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) SPG4 PF17325.2 AAS52381.1 - 1.1e-36 126.3 0.0 1.2e-36 126.1 0.0 1.0 1 0 0 1 1 1 1 Stationary phase protein 4 SHOCT PF09851.9 AAS52381.1 - 0.13 12.1 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 Short C-terminal domain Mid2 PF04478.12 AAS52382.1 - 4.2e-55 185.7 0.4 4.2e-55 185.7 0.4 2.4 2 1 0 2 2 2 1 Mid2 like cell wall stress sensor LAP1C PF05609.12 AAS52382.1 - 0.012 14.7 11.5 0.017 14.3 11.5 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2407_C PF13373.6 AAS52382.1 - 0.73 10.0 2.1 2.7 8.2 0.0 2.7 3 0 0 3 3 3 0 DUF2407 C-terminal domain SWI-SNF_Ssr4 PF08549.10 AAS52382.1 - 0.97 8.0 15.5 1.2 7.7 15.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Orf78 PF06024.12 AAS52382.1 - 1.2 9.5 0.0 1.2 9.5 0.0 2.7 2 1 0 2 2 2 0 Orf78 (ac78) GREB1 PF15782.5 AAS52382.1 - 4.7 4.2 19.2 5.7 3.9 19.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 AAS52382.1 - 6.5 5.2 16.0 8 4.9 16.0 1.1 1 0 0 1 1 1 0 Utp14 protein Nop14 PF04147.12 AAS52382.1 - 8.3 4.5 10.6 11 4.0 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family E1-E2_ATPase PF00122.20 AAS52383.2 - 2.6e-49 167.2 0.1 2.6e-49 167.2 0.1 2.2 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 AAS52383.2 - 9.4e-47 159.1 0.7 9.4e-47 159.1 0.7 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AAS52383.2 - 2e-20 74.0 0.2 1e-19 71.7 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS52383.2 - 1e-17 64.0 0.0 2.1e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AAS52383.2 - 2.7e-13 49.4 0.0 5.5e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AAS52383.2 - 2.5e-05 24.2 1.0 0.00036 20.3 0.9 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AAS52383.2 - 0.074 13.4 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Sua5_yciO_yrdC PF01300.18 AAS52384.1 - 2.3e-49 167.3 0.0 5.1e-49 166.2 0.0 1.5 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.13 AAS52384.1 - 1.5e-28 100.0 0.0 2.4e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding DisA-linker PF10635.9 AAS52384.1 - 0.06 13.1 0.1 0.098 12.4 0.1 1.3 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region Zn_clus PF00172.18 AAS52386.2 - 0.00039 20.5 12.4 0.0014 18.7 2.3 2.3 2 0 0 2 2 2 2 Fungal Zn(2)-Cys(6) binuclear cluster domain SNF2_N PF00176.23 AAS52387.2 - 1e-57 195.5 0.0 1.4e-57 195.0 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Rad54_N PF08658.10 AAS52387.2 - 2.2e-42 145.2 0.1 2.4e-41 141.9 0.1 2.1 2 0 0 2 2 2 1 Rad54 N terminal Helicase_C PF00271.31 AAS52387.2 - 6.2e-17 61.9 0.0 3.6e-16 59.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52387.2 - 2e-06 27.9 0.0 4.4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS52387.2 - 6.5e-05 22.2 0.1 0.00038 19.7 0.1 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 AAS52387.2 - 0.00018 20.8 0.0 0.00043 19.6 0.0 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Zn_ribbon_SprT PF17283.2 AAS52387.2 - 0.34 10.8 2.8 0.45 10.5 0.3 2.4 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Ran-binding PF05508.11 AAS52388.1 - 5.2e-104 347.6 2.3 6.5e-104 347.3 2.3 1.1 1 0 0 1 1 1 1 RanGTP-binding protein Copper-fist PF00649.18 AAS52389.1 - 6.6e-21 73.5 0.8 6.6e-21 73.5 0.8 2.0 1 1 1 2 2 2 1 Copper fist DNA binding domain FTR1 PF03239.14 AAS52390.1 - 1.7e-85 286.9 8.9 2e-85 286.6 8.9 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Peptidase_U4 PF03419.13 AAS52390.1 - 0.005 16.2 2.6 0.005 16.2 2.6 2.2 2 0 0 2 2 2 1 Sporulation factor SpoIIGA UPF0016 PF01169.19 AAS52390.1 - 0.21 12.0 6.9 1.9 8.9 0.1 2.9 2 0 0 2 2 2 0 Uncharacterized protein family UPF0016 TauE PF01925.19 AAS52390.1 - 2.5 7.7 19.2 0.84 9.2 2.6 2.8 1 1 0 2 2 2 0 Sulfite exporter TauE/SafE FlgN PF05130.12 AAS52391.2 - 0.027 15.0 7.4 0.033 14.7 5.3 2.1 1 1 1 2 2 2 0 FlgN protein NYD-SP28_assoc PF14775.6 AAS52391.2 - 0.046 13.8 1.0 0.75 9.9 0.0 2.6 2 0 0 2 2 2 0 Sperm tail C-terminal domain CRR7 PF12095.8 AAS52391.2 - 0.073 13.5 1.9 0.085 13.3 0.7 1.7 2 0 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Bacillus_HBL PF05791.11 AAS52391.2 - 0.17 11.7 1.0 0.28 11.0 0.6 1.6 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) DivIC PF04977.15 AAS52391.2 - 0.43 10.4 4.8 0.58 10.0 2.2 2.1 2 0 0 2 2 2 0 Septum formation initiator DUF2161 PF09929.9 AAS52391.2 - 0.44 10.7 2.3 13 5.9 0.1 2.4 1 1 1 2 2 2 0 Putative PD-(D/E)XK phosphodiesterase (DUF2161) Rad21_Rec8_N PF04825.13 AAS52392.2 - 4.1e-15 55.9 0.0 9.1e-15 54.8 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Bromodomain PF00439.25 AAS52393.1 - 1.4e-30 105.2 5.1 7.1e-21 74.1 0.2 2.6 2 0 0 2 2 2 2 Bromodomain LAMTOR PF15454.6 AAS52394.2 - 3.9e-21 75.4 5.2 5.1e-21 75.1 5.2 1.2 1 0 0 1 1 1 1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Ribosomal_L50 PF10501.9 AAS52395.1 - 3.3e-25 88.4 0.0 6.8e-25 87.3 0.0 1.6 1 0 0 1 1 1 1 Ribosomal subunit 39S TFIIS_M PF07500.14 AAS52395.1 - 0.0066 16.9 0.2 0.016 15.7 0.2 1.7 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Oxysterol_BP PF01237.18 AAS52397.2 - 9.1e-80 268.3 0.0 1.1e-72 245.0 0.0 2.0 1 1 1 2 2 2 2 Oxysterol-binding protein eIF2A PF08662.11 AAS52398.2 - 1.9e-74 249.8 0.0 1.3e-73 247.1 0.0 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 AAS52398.2 - 0.00024 21.8 0.1 27 5.8 0.0 5.0 4 1 1 5 5 5 2 WD domain, G-beta repeat MMU163 PF17119.5 AAS52399.1 - 5.6e-10 38.8 0.3 1.9e-07 30.5 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial protein up-regulated during meiosis Pkinase PF00069.25 AAS52400.2 - 1.6e-50 171.9 0.0 2.2e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52400.2 - 1.7e-33 116.0 0.0 2.5e-33 115.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52400.2 - 1.4e-10 40.9 0.0 6.4e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 AAS52400.2 - 0.0012 18.8 0.0 0.16 11.9 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS52400.2 - 0.058 12.3 0.0 0.077 11.9 0.0 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 AAS52400.2 - 0.1 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 USP19_linker PF16602.5 AAS52401.1 - 0.0087 16.6 0.7 0.072 13.6 0.1 2.0 2 0 0 2 2 2 1 Linker region of USP19 deubiquitinase RNA_pol_Rpc82 PF05645.13 AAS52402.1 - 3.8e-70 236.6 0.1 6.4e-70 235.9 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 HTH_9 PF08221.11 AAS52402.1 - 6.6e-25 87.0 5.7 6.4e-21 74.2 0.5 3.5 3 0 0 3 3 3 2 RNA polymerase III subunit RPC82 helix-turn-helix domain TFIIE_alpha PF02002.17 AAS52402.1 - 8.8e-09 35.2 0.9 0.0034 17.2 0.0 2.9 2 0 0 2 2 2 2 TFIIE alpha subunit Rio2_N PF09202.11 AAS52402.1 - 0.034 14.4 0.5 1.2 9.3 0.1 2.8 2 0 0 2 2 2 0 Rio2, N-terminal DUF4367 PF14285.6 AAS52402.1 - 0.048 14.1 0.1 0.15 12.5 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) MlaE PF02405.16 AAS52402.1 - 0.16 11.6 0.1 0.28 10.8 0.1 1.3 1 0 0 1 1 1 0 Permease MlaE TPR_22 PF18833.1 AAS52403.2 - 4.1e-38 129.4 0.7 1.1e-37 128.0 0.3 2.1 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS52403.2 - 1.1e-26 93.0 8.7 3.5e-05 24.2 0.0 9.1 8 2 2 10 10 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 AAS52403.2 - 5.7e-23 79.7 9.0 0.00015 22.3 0.1 12.6 8 3 5 13 13 12 5 Tetratricopeptide repeat TPR_2 PF07719.17 AAS52403.2 - 5.9e-21 72.8 26.1 4.3e-06 26.4 0.0 13.2 16 0 0 16 16 12 4 Tetratricopeptide repeat TPR_1 PF00515.28 AAS52403.2 - 2.5e-19 68.2 16.5 5.6e-06 26.0 0.0 10.6 11 1 0 11 11 11 3 Tetratricopeptide repeat TPR_16 PF13432.6 AAS52403.2 - 6e-19 68.4 9.7 5.6e-05 23.7 0.1 8.4 7 2 2 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 AAS52403.2 - 9.3e-17 59.8 9.4 5.7e-06 26.1 0.0 9.6 10 0 0 10 10 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 AAS52403.2 - 2.5e-14 52.8 2.1 0.37 11.5 0.0 8.6 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 AAS52403.2 - 6e-14 52.1 14.7 0.035 14.4 0.2 7.9 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 AAS52403.2 - 6e-12 45.1 6.0 2.3e-05 24.0 0.0 8.0 9 2 2 11 11 10 2 TPR repeat TPR_7 PF13176.6 AAS52403.2 - 6.4e-10 38.4 9.7 0.042 13.9 0.0 10.4 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_9 PF13371.6 AAS52403.2 - 6.8e-09 35.8 14.9 0.019 15.1 0.1 7.5 8 1 0 8 8 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS52403.2 - 9.2e-08 32.2 19.5 0.00033 20.8 0.2 7.1 7 1 1 8 8 7 3 Anaphase-promoting complex, cyclosome, subunit 3 HrpB1_HrpK PF09613.10 AAS52403.2 - 3.2e-07 30.0 0.1 0.0015 18.1 0.0 3.4 3 0 0 3 3 3 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_17 PF13431.6 AAS52403.2 - 1.6e-06 28.1 7.4 0.65 10.5 0.0 9.8 11 0 0 11 11 10 1 Tetratricopeptide repeat TPR_15 PF13429.6 AAS52403.2 - 0.00011 21.6 9.7 0.0078 15.5 0.1 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_4 PF07721.14 AAS52403.2 - 0.00012 22.4 0.0 25 5.9 0.0 5.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_20 PF14561.6 AAS52403.2 - 0.00029 21.1 0.6 2.2 8.7 0.0 4.9 4 1 1 5 5 4 1 Tetratricopeptide repeat PknG_TPR PF16918.5 AAS52403.2 - 0.0034 16.2 0.1 0.036 12.8 0.0 2.4 3 0 0 3 3 3 1 Protein kinase G tetratricopeptide repeat TPR_MalT PF17874.1 AAS52403.2 - 0.0064 15.9 1.3 2.6 7.3 0.0 4.2 4 1 1 5 5 5 2 MalT-like TPR region BTAD PF03704.17 AAS52403.2 - 0.012 16.0 2.8 7.3 7.0 0.0 4.4 3 1 1 4 4 4 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 AAS52403.2 - 0.013 15.4 4.1 16 5.5 0.1 6.3 7 0 0 7 7 7 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AAS52403.2 - 0.79 10.2 2.9 38 4.7 0.0 4.2 4 1 1 5 5 5 0 Alkyl sulfatase dimerisation ChAPs PF09295.10 AAS52403.2 - 2.1 7.3 8.7 17 4.3 0.0 4.3 3 1 2 5 5 5 0 ChAPs (Chs5p-Arf1p-binding proteins) EF-hand_7 PF13499.6 AAS52404.1 - 1.5e-06 28.5 0.3 4.4e-06 27.0 0.1 2.0 1 1 1 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 AAS52404.1 - 1.8e-06 27.4 0.4 1.1e-05 24.9 0.2 2.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 AAS52404.1 - 2e-06 26.9 0.2 8.8e-06 24.9 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 AAS52404.1 - 8.2e-06 25.1 0.8 2.1e-05 23.8 0.8 1.7 1 0 0 1 1 1 1 EF hand CUE PF02845.16 AAS52404.1 - 0.019 14.6 1.0 3.7 7.3 0.0 2.9 3 0 0 3 3 3 0 CUE domain EF-hand_8 PF13833.6 AAS52404.1 - 0.023 14.5 0.5 0.15 11.9 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain pair RNA_pol_Rpb6 PF01192.22 AAS52405.1 - 8.7e-17 60.8 0.1 1.2e-16 60.3 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb6 zf-C2H2 PF00096.26 AAS52406.2 - 3.4e-28 96.5 61.8 5.4e-05 23.4 2.8 9.6 9 0 0 9 9 9 8 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS52406.2 - 3.4e-21 74.1 61.8 0.00086 19.9 4.2 9.8 9 0 0 9 9 9 7 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS52406.2 - 3.9e-08 33.4 57.1 0.0092 16.4 0.9 9.2 10 0 0 10 10 10 6 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS52406.2 - 1.3e-06 28.5 27.4 0.03 14.6 0.8 7.3 8 0 0 8 8 8 3 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AAS52406.2 - 2.6e-06 27.6 29.9 0.34 11.4 0.0 7.2 8 0 0 8 8 8 5 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 AAS52406.2 - 0.00075 19.2 1.4 0.00075 19.2 1.4 5.5 6 0 0 6 6 6 1 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 AAS52406.2 - 0.0089 16.3 26.1 0.14 12.5 4.1 4.9 2 1 3 5 5 5 2 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 AAS52406.2 - 0.022 14.9 1.5 0.022 14.9 1.5 4.1 3 1 0 3 3 3 0 Zinc ribbon domain DUF4279 PF14106.6 AAS52406.2 - 0.17 12.1 0.3 0.45 10.7 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) zf-C2HE PF16278.5 AAS52406.2 - 0.45 11.0 31.4 18 5.9 0.7 5.8 2 2 3 5 5 5 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 AAS52406.2 - 0.9 10.2 24.5 2.2 9.0 3.0 5.3 3 1 3 6 6 6 0 Zinc finger C2H2-type, 3 repeats ATG13 PF10033.9 AAS52407.1 - 3.5e-63 213.5 0.0 6.8e-63 212.6 0.0 1.5 1 0 0 1 1 1 1 Autophagy-related protein 13 hDGE_amylase PF14701.6 AAS52408.1 - 1.3e-172 574.9 0.0 1.7e-172 574.5 0.0 1.1 1 0 0 1 1 1 1 Glycogen debranching enzyme, glucanotransferase domain GDE_C PF06202.14 AAS52408.1 - 7.3e-127 423.5 0.0 1e-126 423.0 0.0 1.2 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase hGDE_central PF14702.6 AAS52408.1 - 1.1e-72 244.8 0.0 1.7e-72 244.1 0.0 1.3 1 0 0 1 1 1 1 Central domain of human glycogen debranching enzyme hGDE_N PF14699.6 AAS52408.1 - 1.8e-22 79.3 0.5 4.7e-22 77.9 0.0 2.0 2 0 0 2 2 2 1 N-terminal domain from the human glycogen debranching enzyme Alpha-amylase PF00128.24 AAS52408.1 - 0.00019 21.1 0.1 0.00086 19.0 0.0 1.9 2 0 0 2 2 2 1 Alpha amylase, catalytic domain Glycos_transf_2 PF00535.26 AAS52409.1 - 1.1e-31 110.0 0.0 1.4e-31 109.6 0.0 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AAS52409.1 - 2.2e-08 34.3 0.0 3.5e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 AAS52409.1 - 0.0056 16.2 0.0 0.009 15.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 SUA5 PF03481.13 AAS52409.1 - 0.072 13.7 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative GTP-binding controlling metal-binding LSM PF01423.22 AAS52410.1 - 1.1e-15 57.0 0.2 1.3e-15 56.8 0.2 1.0 1 0 0 1 1 1 1 LSM domain PIG-U PF06728.13 AAS52411.1 - 2e-98 329.9 39.2 2.9e-98 329.4 39.2 1.2 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U Sec23_trunk PF04811.15 AAS52412.1 - 3.1e-73 246.3 0.0 4.2e-73 245.9 0.0 1.2 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 AAS52412.1 - 7.6e-29 100.3 0.1 1.4e-28 99.4 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_helical PF04815.15 AAS52412.1 - 1.7e-27 95.2 0.0 4.1e-27 94.0 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 AAS52412.1 - 3e-14 52.8 3.0 5.7e-14 51.9 3.0 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Gelsolin PF00626.22 AAS52412.1 - 1.4e-11 44.1 0.0 2.8e-11 43.2 0.0 1.5 1 0 0 1 1 1 1 Gelsolin repeat Vps36-NZF-N PF16988.5 AAS52412.1 - 0.057 12.8 0.1 0.13 11.6 0.1 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Tagatose_6_P_K PF08013.11 AAS52412.1 - 0.078 11.6 0.0 0.14 10.8 0.0 1.3 1 0 0 1 1 1 0 Tagatose 6 phosphate kinase MHC_I PF00129.18 AAS52412.1 - 0.19 11.3 0.0 0.61 9.6 0.0 1.7 2 0 0 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 ThiF PF00899.21 AAS52413.2 - 4.1e-33 114.7 0.0 5.6e-33 114.3 0.0 1.2 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 AAS52413.2 - 0.11 12.6 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Delta_lysin PF05372.11 AAS52413.2 - 0.21 10.9 0.3 0.5 9.7 0.3 1.7 1 0 0 1 1 1 0 Delta lysin family HDA2-3 PF11496.8 AAS52414.2 - 4.1e-93 311.7 0.1 4.1e-93 311.7 0.1 2.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Spc7 PF08317.11 AAS52414.2 - 1.1e-05 24.5 18.9 1.1e-05 24.5 18.9 2.2 1 1 1 2 2 2 1 Spc7 kinetochore protein MitMem_reg PF13012.6 AAS52414.2 - 4.6 7.7 8.5 1.1 9.7 1.3 3.1 1 1 0 2 2 2 0 Maintenance of mitochondrial structure and function Leu_zip PF15294.6 AAS52414.2 - 6.3 6.2 27.8 0.04 13.4 13.7 2.3 1 1 2 3 3 3 0 Leucine zipper DUF4441 PF14536.6 AAS52414.2 - 8.9 6.5 10.8 0.25 11.5 0.9 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4441) WD40 PF00400.32 AAS52415.1 - 5.7e-40 134.6 13.8 4.7e-09 36.7 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52415.1 - 3.4e-18 65.7 2.5 0.0078 16.5 0.0 5.4 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS52415.1 - 1.8e-05 24.7 0.0 0.025 14.5 0.0 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 AAS52415.1 - 5.6e-05 22.3 0.1 0.011 14.8 0.0 3.2 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AAS52415.1 - 0.043 13.1 0.0 5.5 6.2 0.0 2.9 3 1 1 4 4 4 0 WD40-like domain PRP4 PF08799.11 AAS52415.1 - 1.1 8.8 4.1 13 5.5 1.8 3.3 3 0 0 3 3 3 0 pre-mRNA processing factor 4 (PRP4) like Prenyltrans PF00432.21 AAS52416.1 - 1.3e-58 194.3 10.7 6.2e-13 48.2 0.0 6.1 6 0 0 6 6 6 5 Prenyltransferase and squalene oxidase repeat SQHop_cyclase_C PF13243.6 AAS52416.1 - 2.6e-05 23.5 0.0 0.00013 21.2 0.0 2.1 1 1 1 2 2 2 1 Squalene-hopene cyclase C-terminal domain TED_complement PF07678.14 AAS52416.1 - 0.02 14.0 0.0 0.11 11.5 0.0 2.1 1 1 1 2 2 2 0 A-macroglobulin TED domain SQHop_cyclase_N PF13249.6 AAS52416.1 - 0.093 11.8 0.0 49 2.9 0.0 3.6 1 1 4 5 5 5 0 Squalene-hopene cyclase N-terminal domain DUF1127 PF06568.11 AAS52416.1 - 0.25 11.1 2.1 0.34 10.7 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1127) DNA_pol_E_B PF04042.16 AAS52417.1 - 1.1e-52 178.5 0.5 1.6e-52 178.0 0.5 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dioxygenase_N PF04444.14 AAS52417.1 - 0.14 12.0 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Catechol dioxygenase N terminus NBP1 PF08537.10 AAS52418.1 - 1e-110 370.4 4.6 1.1e-110 370.2 4.6 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 DMAP_binding PF06464.11 AAS52418.1 - 0.012 16.4 1.9 0.012 16.4 1.9 1.8 2 0 0 2 2 2 0 DMAP1-binding Domain CorA PF01544.18 AAS52418.1 - 0.2 10.9 1.1 0.3 10.4 1.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein AAA PF00004.29 AAS52419.1 - 1.6e-43 148.3 0.0 3.1e-43 147.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 AAS52419.1 - 3.1e-29 100.7 0.1 1.1e-28 98.9 0.2 1.9 2 0 0 2 2 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 AAS52419.1 - 1.2e-22 79.7 2.9 3e-22 78.5 2.9 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_16 PF13191.6 AAS52419.1 - 1.7e-06 28.5 0.5 7.5e-05 23.2 0.0 3.1 3 1 0 3 3 2 1 AAA ATPase domain AAA_lid_3 PF17862.1 AAS52419.1 - 2e-06 27.5 0.0 6.6e-06 25.8 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 AAS52419.1 - 5.5e-06 26.2 0.0 9.4e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AAS52419.1 - 8.2e-06 26.1 0.1 0.00085 19.6 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AAS52419.1 - 2.4e-05 24.3 0.0 9.1e-05 22.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 AAS52419.1 - 6.2e-05 22.8 0.0 0.00013 21.8 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 AAS52419.1 - 7.1e-05 22.2 0.0 0.00012 21.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain DUF815 PF05673.13 AAS52419.1 - 7.3e-05 22.0 0.0 0.00031 20.0 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF815) AAA_14 PF13173.6 AAS52419.1 - 0.00012 22.1 0.0 0.00034 20.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 AAS52419.1 - 0.00018 21.9 0.1 0.009 16.4 0.0 2.8 3 0 0 3 3 2 1 RNA helicase AAA_2 PF07724.14 AAS52419.1 - 0.00051 20.2 0.0 0.0025 17.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 AAS52419.1 - 0.00091 19.8 0.0 0.0022 18.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AAS52419.1 - 0.0019 18.4 0.1 0.0052 16.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AAS52419.1 - 0.0044 16.8 0.0 0.0099 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 AAS52419.1 - 0.0055 16.3 0.1 0.2 11.2 0.1 2.3 1 1 0 2 2 2 1 AAA domain ATPase PF06745.13 AAS52419.1 - 0.0057 16.0 0.0 3.1 7.1 0.0 2.3 1 1 1 2 2 2 2 KaiC AAA_17 PF13207.6 AAS52419.1 - 0.012 16.1 0.0 0.034 14.6 0.0 1.8 2 0 0 2 2 1 0 AAA domain AAA_7 PF12775.7 AAS52419.1 - 0.029 13.9 0.0 0.077 12.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 AAS52419.1 - 0.032 13.6 0.0 0.082 12.3 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Torsin PF06309.11 AAS52419.1 - 0.033 14.3 0.0 0.067 13.3 0.0 1.4 1 0 0 1 1 1 0 Torsin PhoH PF02562.16 AAS52419.1 - 0.079 12.4 0.1 0.16 11.4 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 AAS52419.1 - 0.085 12.8 0.1 2.3 8.1 0.0 2.4 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 AAS52419.1 - 0.086 12.1 0.2 1 8.6 0.1 2.4 1 1 2 3 3 3 0 Zeta toxin Sigma54_activat PF00158.26 AAS52419.1 - 0.091 12.5 0.0 0.27 10.9 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 AAS52419.1 - 0.094 12.6 0.0 0.64 9.9 0.0 2.2 1 1 1 2 2 2 0 NACHT domain Parvo_NS1 PF01057.17 AAS52419.1 - 0.096 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 CPT PF07931.12 AAS52419.1 - 0.16 11.8 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Putative_PNPOx PF01243.20 AAS52420.2 - 2e-16 59.9 0.0 3.9e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AAS52420.2 - 0.0014 18.6 0.1 0.0035 17.3 0.0 1.6 1 1 1 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 AAS52420.2 - 0.002 18.1 0.0 0.0056 16.7 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Phage_TTP_1 PF04630.12 AAS52420.2 - 0.038 13.3 0.1 0.049 13.0 0.1 1.2 1 0 0 1 1 1 0 Phage tail tube protein PWWP PF00855.17 AAS52421.1 - 1e-16 61.1 0.1 2e-16 60.2 0.1 1.5 1 0 0 1 1 1 1 PWWP domain DUF1282 PF06930.12 AAS52423.1 - 0.025 14.4 0.3 0.028 14.2 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) ANAPC4_WD40 PF12894.7 AAS52424.2 - 9e-05 22.7 1.2 0.065 13.5 0.1 3.7 2 2 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 AAS52424.2 - 0.0091 16.5 0.2 11 6.7 0.0 3.7 3 1 0 3 3 3 1 PQQ-like domain WD40 PF00400.32 AAS52424.2 - 0.014 16.2 5.6 0.11 13.4 0.3 4.4 6 0 0 6 6 6 0 WD domain, G-beta repeat SGL PF08450.12 AAS52424.2 - 0.026 14.1 1.2 0.78 9.3 0.1 2.9 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region BTV_NS2 PF04514.12 AAS52424.2 - 0.09 11.6 0.0 0.09 11.6 0.0 2.6 3 0 0 3 3 3 0 Bluetongue virus non-structural protein NS2 MRI PF15325.6 AAS52424.2 - 0.27 12.3 10.8 0.22 12.6 8.8 1.9 2 0 0 2 2 2 0 Modulator of retrovirus infection Host_attach PF10116.9 AAS52424.2 - 9 6.9 8.4 13 6.3 0.7 3.0 1 1 2 3 3 3 0 Protein required for attachment to host cells Med10 PF09748.9 AAS52425.2 - 1.7e-38 131.3 0.2 2.1e-38 131.0 0.2 1.1 1 0 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex PAPS_reduct PF01507.19 AAS52426.1 - 8.9e-39 133.3 0.0 1.1e-38 133.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family AAA PF00004.29 AAS52427.2 - 1e-31 110.1 0.0 2.1e-31 109.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AAS52427.2 - 8.8e-08 32.5 0.0 2.6e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS52427.2 - 7.5e-06 26.4 0.1 2.7e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain Rad17 PF03215.15 AAS52427.2 - 0.00028 20.9 0.4 0.00083 19.3 0.1 1.9 2 1 0 2 2 1 1 Rad17 P-loop domain AAA_19 PF13245.6 AAS52427.2 - 0.00062 20.1 0.7 0.0049 17.2 0.5 2.4 2 1 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 AAS52427.2 - 0.00074 19.9 0.0 0.002 18.5 0.0 1.8 1 1 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 AAS52427.2 - 0.00094 19.7 0.0 0.0025 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS52427.2 - 0.001 18.8 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AAS52427.2 - 0.0016 18.3 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AAS52427.2 - 0.0017 18.4 0.2 0.0047 17.0 0.2 1.7 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 AAS52427.2 - 0.0017 17.7 0.0 0.0024 17.2 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_33 PF13671.6 AAS52427.2 - 0.0025 18.0 0.0 0.0047 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AAS52427.2 - 0.0026 17.8 0.4 0.099 12.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AAS52427.2 - 0.0044 16.4 0.0 0.0073 15.7 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 AAS52427.2 - 0.022 14.5 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 AAS52427.2 - 0.022 14.7 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain MarR PF01047.22 AAS52427.2 - 0.023 14.6 0.0 0.082 12.8 0.0 2.0 2 0 0 2 2 1 0 MarR family AAA_7 PF12775.7 AAS52427.2 - 0.025 14.1 0.1 0.21 11.1 0.1 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region ABC_tran PF00005.27 AAS52427.2 - 0.033 14.7 0.0 0.088 13.3 0.0 1.8 2 0 0 2 2 1 0 ABC transporter AAA_24 PF13479.6 AAS52427.2 - 0.037 13.8 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AAS52427.2 - 0.042 13.4 0.0 0.095 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 AAS52427.2 - 0.049 13.5 0.7 8.2 6.3 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_17 PF13207.6 AAS52427.2 - 0.056 13.9 0.6 0.13 12.7 0.1 1.9 2 0 0 2 2 1 0 AAA domain AAA_23 PF13476.6 AAS52427.2 - 0.057 13.9 1.1 0.19 12.2 1.1 1.9 1 1 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 AAS52427.2 - 0.06 13.1 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase Viral_helicase1 PF01443.18 AAS52427.2 - 0.065 13.0 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TsaE PF02367.17 AAS52427.2 - 0.072 13.1 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 AAS52427.2 - 0.084 12.8 0.1 0.17 11.8 0.1 1.5 1 0 0 1 1 1 0 NTPase ATPase PF06745.13 AAS52427.2 - 0.091 12.1 0.4 1.7 8.0 0.0 2.2 2 0 0 2 2 2 0 KaiC NB-ARC PF00931.22 AAS52427.2 - 0.13 11.5 0.0 0.25 10.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain UPF0016 PF01169.19 AAS52428.1 - 1.3e-39 134.4 28.3 1.3e-21 76.7 5.0 2.4 3 0 0 3 3 3 2 Uncharacterized protein family UPF0016 MFS_1 PF07690.16 AAS52428.1 - 4.5e-05 22.5 7.1 0.0001 21.4 7.1 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily OFeT_1 PF16955.5 AAS52428.1 - 0.0025 17.5 1.9 0.0027 17.4 0.1 1.9 2 0 0 2 2 2 1 Ferrous iron uptake permease, iron-lead transporter LysE PF01810.18 AAS52428.1 - 0.31 10.5 13.2 0.15 11.5 3.4 2.5 2 1 0 2 2 2 0 LysE type translocator DUF4131 PF13567.6 AAS52428.1 - 0.43 10.2 1.8 2.3 7.9 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Deltameth_res PF16020.5 AAS52428.1 - 7.4 6.5 6.1 43 4.1 0.0 3.7 4 0 0 4 4 4 0 Deltamethrin resistance DUF3535 PF12054.8 AAS52429.2 - 1.7e-115 386.8 9.1 3.9e-115 385.5 0.3 4.1 4 1 0 5 5 5 1 Domain of unknown function (DUF3535) SNF2_N PF00176.23 AAS52429.2 - 3.6e-69 233.1 0.0 6.1e-69 232.4 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS52429.2 - 5.3e-19 68.6 0.0 2.5e-18 66.4 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HEAT PF02985.22 AAS52429.2 - 7.7e-14 50.6 8.5 0.19 12.0 0.0 8.6 8 0 0 8 8 7 5 HEAT repeat ResIII PF04851.15 AAS52429.2 - 1.4e-05 25.1 0.0 6.9e-05 22.9 0.0 2.2 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Vac14_Fab1_bd PF12755.7 AAS52429.2 - 6.6e-05 23.4 0.9 0.64 10.6 0.0 4.9 6 0 0 6 6 5 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 AAS52429.2 - 0.00018 21.8 7.7 3.7 8.0 0.2 7.1 6 2 1 7 7 6 1 HEAT repeats TAF6_C PF07571.13 AAS52429.2 - 0.00072 19.8 0.1 1.4 9.3 0.0 4.8 3 1 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain HEAT_EZ PF13513.6 AAS52429.2 - 0.0028 18.1 18.9 8.7 7.0 0.3 8.3 10 0 0 10 10 9 1 HEAT-like repeat ERCC3_RAD25_C PF16203.5 AAS52429.2 - 0.0076 15.5 0.0 0.021 14.0 0.0 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase GUN4_N PF16416.5 AAS52429.2 - 0.053 13.5 0.6 1.1 9.4 0.1 2.6 2 0 0 2 2 2 0 ARM-like repeat domain, GUN4-N terminal Condensin2nSMC PF12422.8 AAS52429.2 - 0.83 9.8 4.8 6.2 7.0 0.8 3.7 3 1 1 4 4 4 0 Condensin II non structural maintenance of chromosomes subunit HEAT_PBS PF03130.16 AAS52429.2 - 6.3 7.8 7.4 20 6.2 0.0 4.8 4 0 0 4 4 2 0 PBS lyase HEAT-like repeat S4 PF01479.25 AAS52430.1 - 3.4e-11 42.7 0.3 3.4e-11 42.7 0.3 2.0 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 AAS52430.1 - 6.5e-05 23.8 0.2 9.2e-05 23.3 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Ribosomal_L21e PF01157.18 AAS52431.1 - 1.5e-47 159.6 5.0 1.5e-47 159.6 5.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L21e LRS4 PF10422.9 AAS52431.1 - 0.019 14.6 0.0 0.022 14.3 0.0 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 SIMPL PF04402.14 AAS52431.1 - 0.021 15.3 0.0 0.025 15.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) Mito_carr PF00153.27 AAS52432.1 - 3.1e-76 251.4 1.4 1.9e-26 91.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 AAS52432.1 - 0.0038 17.4 0.0 0.77 10.0 0.0 3.3 3 1 1 4 4 4 1 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Med8 PF10232.9 AAS52433.1 - 1.8e-15 57.2 0.0 5.1e-15 55.7 0.0 1.5 1 1 1 2 2 2 1 Mediator of RNA polymerase II transcription complex subunit 8 NPV_P10 PF05531.12 AAS52433.1 - 0.035 14.6 0.2 5.6 7.5 0.1 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein CK2S PF15011.6 AAS52433.1 - 0.065 13.1 0.6 0.24 11.3 0.2 2.1 2 1 1 3 3 3 0 Casein Kinase 2 substrate DASH_Hsk3 PF08227.11 AAS52433.1 - 0.95 9.9 4.5 3.1 8.2 1.0 2.9 3 1 0 3 3 3 0 DASH complex subunit Hsk3 like Mt_ATP-synt_B PF05405.14 AAS52434.2 - 5.1e-57 192.0 9.5 6.1e-57 191.8 9.5 1.0 1 0 0 1 1 1 1 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CAF1C_H4-bd PF12265.8 AAS52435.1 - 6.1e-18 64.8 1.0 1.4e-17 63.7 1.0 1.7 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 AAS52435.1 - 4.5e-11 43.1 15.9 0.00093 20.0 0.1 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat PGI PF00342.19 AAS52436.1 - 7.1e-248 823.0 3.0 8.2e-248 822.8 3.0 1.0 1 0 0 1 1 1 1 Phosphoglucose isomerase DUF5315 PF17242.2 AAS52437.1 - 8.7e-23 79.9 0.3 1.2e-22 79.5 0.3 1.2 1 0 0 1 1 1 1 Disordered region of unknown function (DUF5315) GPI2 PF06432.11 AAS52438.1 - 1.2e-53 182.4 21.0 4.1e-53 180.7 21.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Tmpp129 PF10272.9 AAS52438.1 - 9.8 5.4 8.6 3 7.0 0.7 2.2 2 0 0 2 2 2 0 Putative transmembrane protein precursor WD40 PF00400.32 AAS52439.1 - 1.2e-56 187.4 18.9 7.8e-10 39.2 0.1 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 AAS52439.1 - 1.2e-42 145.2 1.5 2e-42 144.5 1.5 1.3 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 AAS52439.1 - 5.8e-16 58.6 0.2 0.31 11.4 0.0 6.6 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS52439.1 - 1.8e-09 37.4 0.0 0.002 17.5 0.0 4.1 2 1 2 4 4 4 3 WD40-like domain LisH PF08513.11 AAS52439.1 - 9.1e-07 28.6 0.1 2.2e-06 27.4 0.1 1.7 1 0 0 1 1 1 1 LisH Ge1_WD40 PF16529.5 AAS52439.1 - 3.6e-06 26.2 0.1 0.31 10.0 0.0 4.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 AAS52439.1 - 3.8e-06 25.8 0.1 0.01 14.5 0.0 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 AAS52439.1 - 0.017 13.9 0.8 0.53 9.0 0.2 3.2 1 1 0 2 2 2 0 Nup133 N terminal like PD40 PF07676.12 AAS52439.1 - 0.026 14.4 0.0 21 5.2 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat nos_propeller PF18764.1 AAS52439.1 - 0.027 14.4 0.1 27 4.8 0.0 3.5 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Cytochrom_D1 PF02239.16 AAS52439.1 - 0.072 11.6 0.2 1.4 7.4 0.1 2.5 2 1 2 4 4 4 0 Cytochrome D1 heme domain Frtz PF11768.8 AAS52439.1 - 0.083 11.2 0.0 4.3 5.5 0.0 2.4 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz ELYS-bb PF16687.5 AAS52439.1 - 0.11 11.1 0.0 1.2 7.6 0.0 2.1 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin DUF4632 PF15451.6 AAS52439.1 - 0.77 9.9 2.6 2.2 8.4 2.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) GCR1_C PF12550.8 AAS52440.1 - 1.7e-24 85.9 0.7 3.7e-24 84.8 0.7 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes NDC10_II PF16787.5 AAS52440.1 - 6.9e-07 28.6 0.5 1.4e-05 24.4 0.0 2.3 2 0 0 2 2 2 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 TolA_bind_tri PF16331.5 AAS52440.1 - 0.0012 18.9 0.2 0.0038 17.3 0.2 1.9 1 0 0 1 1 1 1 TolA binding protein trimerisation SKA2 PF16740.5 AAS52440.1 - 0.0013 18.5 0.5 0.0032 17.2 0.5 1.6 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 DUF5082 PF16888.5 AAS52440.1 - 0.0084 16.4 1.2 0.018 15.3 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) Syntaxin_2 PF14523.6 AAS52440.1 - 0.024 15.0 2.0 0.084 13.2 2.0 1.9 1 0 0 1 1 1 0 Syntaxin-like protein Jnk-SapK_ap_N PF09744.9 AAS52440.1 - 0.049 13.9 1.5 0.1 12.8 1.5 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF2730 PF10805.8 AAS52440.1 - 0.11 12.6 0.4 0.25 11.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) ACCA PF03255.14 AAS52440.1 - 0.15 11.9 0.3 0.36 10.7 0.3 1.6 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit AAA PF00004.29 AAS52441.1 - 3.1e-39 134.4 0.0 8.8e-39 132.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS52441.1 - 1.1e-10 41.1 0.0 3.9e-10 39.4 0.0 1.9 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 AAS52441.1 - 1.7e-07 31.5 0.8 0.00015 22.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AAS52441.1 - 2.6e-05 24.0 0.0 5.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 AAS52441.1 - 8.2e-05 22.8 2.3 0.038 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AAS52441.1 - 0.00012 22.1 0.0 0.0015 18.5 0.0 2.8 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AAS52441.1 - 0.00013 22.2 0.1 0.033 14.4 0.0 2.7 1 1 1 2 2 2 1 AAA domain TIP49 PF06068.13 AAS52441.1 - 0.00054 19.3 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_11 PF13086.6 AAS52441.1 - 0.0013 18.5 4.2 0.36 10.6 0.0 2.8 2 1 0 2 2 2 1 AAA domain Vps4_C PF09336.10 AAS52441.1 - 0.002 18.1 0.0 0.0082 16.1 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain TniB PF05621.11 AAS52441.1 - 0.0021 17.5 0.0 2.4 7.5 0.0 2.6 2 0 0 2 2 2 2 Bacterial TniB protein Mg_chelatase PF01078.21 AAS52441.1 - 0.0059 16.0 0.2 0.013 14.9 0.2 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AAS52441.1 - 0.0095 15.7 0.0 0.023 14.4 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_14 PF13173.6 AAS52441.1 - 0.013 15.5 0.0 0.05 13.6 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AAS52441.1 - 0.013 15.8 9.0 0.025 15.0 0.0 3.3 2 2 0 3 3 3 0 AAA ATPase domain AAA_23 PF13476.6 AAS52441.1 - 0.021 15.4 8.1 1.2 9.5 6.8 2.8 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AAS52441.1 - 0.031 14.8 4.1 0.065 13.8 0.0 3.4 3 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 AAS52441.1 - 0.041 13.4 0.0 0.46 10.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 AAS52441.1 - 0.069 13.6 5.0 0.55 10.7 0.0 3.5 3 0 0 3 3 2 0 AAA domain AAA_24 PF13479.6 AAS52441.1 - 0.078 12.7 0.0 0.18 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 AAS52441.1 - 0.087 12.2 0.6 7.9 5.8 0.1 2.7 1 1 1 2 2 2 0 KaiC AAA_7 PF12775.7 AAS52441.1 - 0.092 12.3 0.0 0.23 10.9 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region DUF4355 PF14265.6 AAS52441.1 - 0.17 12.1 11.1 0.67 10.2 11.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) Phage_GPO PF05929.11 AAS52441.1 - 0.18 11.4 8.3 0.37 10.4 8.3 1.5 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase AAA_30 PF13604.6 AAS52441.1 - 1.3 8.7 0.0 1.3 8.7 0.0 2.9 3 0 0 3 3 3 0 AAA domain Glyco_transf_15 PF01793.16 AAS52442.1 - 8e-105 350.7 3.6 9.9e-105 350.4 3.6 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DUF948 PF06103.11 AAS52442.1 - 0.087 13.1 0.2 0.17 12.1 0.2 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF5106 PF17127.4 AAS52442.1 - 0.11 12.8 0.8 0.29 11.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) UCH PF00443.29 AAS52443.1 - 2.1e-32 112.7 0.5 2.2e-29 102.7 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS52443.1 - 8.7e-05 22.3 0.1 0.00082 19.1 0.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2777 PF10949.8 AAS52443.1 - 0.073 12.7 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) SH3_1 PF00018.28 AAS52444.1 - 1.9e-23 81.8 0.0 2.9e-11 42.8 0.0 2.6 2 0 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 AAS52444.1 - 1.4e-14 53.7 0.1 6.9e-10 38.6 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain PX PF00787.24 AAS52444.1 - 6.8e-14 51.8 0.0 1.2e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 PX domain SH3_2 PF07653.17 AAS52444.1 - 5.3e-10 38.8 0.1 4.3e-09 35.9 0.0 2.3 2 0 0 2 2 2 1 Variant SH3 domain PB1 PF00564.24 AAS52444.1 - 0.00088 19.2 0.1 0.0025 17.7 0.1 1.8 2 0 0 2 2 2 1 PB1 domain SUIM_assoc PF16619.5 AAS52444.1 - 0.0014 18.7 0.0 0.0062 16.6 0.0 2.1 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 HTS PF04204.16 AAS52444.1 - 0.11 11.4 0.3 0.23 10.4 0.1 1.6 1 1 1 2 2 2 0 Homoserine O-succinyltransferase DUF1419 PF07215.11 AAS52444.1 - 0.12 12.5 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1419) VPS9 PF02204.18 AAS52446.2 - 1.5e-20 73.4 1.4 2.6e-20 72.6 1.4 1.4 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain DUF2524 PF10732.9 AAS52446.2 - 0.15 12.4 0.5 0.62 10.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) Nucleoporin_FG PF13634.6 AAS52446.2 - 3.7 8.5 13.4 0.34 11.8 1.6 2.9 3 0 0 3 3 3 0 Nucleoporin FG repeat region polyprenyl_synt PF00348.17 AAS52447.1 - 1.3e-59 201.4 0.0 1.5e-59 201.2 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase Syntaxin-18_N PF10496.9 AAS52447.1 - 0.068 13.4 0.0 0.2 11.9 0.0 1.8 1 0 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus DER1 PF04511.15 AAS52448.2 - 1.1e-07 31.9 5.2 1.4e-07 31.6 5.2 1.1 1 0 0 1 1 1 1 Der1-like family TetR_C_7 PF14246.6 AAS52449.2 - 0.024 14.7 0.4 0.056 13.5 0.4 1.6 1 0 0 1 1 1 0 AefR-like transcriptional repressor, C-terminal domain Cpn10 PF00166.21 AAS52450.2 - 7.5e-28 96.4 0.1 8.4e-28 96.3 0.1 1.0 1 0 0 1 1 1 1 Chaperonin 10 Kd subunit PRP3 PF08572.10 AAS52451.2 - 2.7e-54 184.3 13.3 4.2e-54 183.6 13.3 1.3 1 0 0 1 1 1 1 pre-mRNA processing factor 3 (PRP3) DUF1115 PF06544.12 AAS52451.2 - 4.1e-20 72.4 0.3 1.1e-14 54.7 0.0 3.2 3 1 1 4 4 4 2 Protein of unknown function (DUF1115) Arf PF00025.21 AAS52453.2 - 3.3e-27 95.1 0.0 5.6e-25 87.8 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family Ras PF00071.22 AAS52453.2 - 3.3e-14 52.8 0.0 5.6e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS52453.2 - 2.5e-12 47.1 0.0 3.8e-12 46.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AAS52453.2 - 7e-09 35.8 0.0 1.5e-08 34.7 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase G-alpha PF00503.20 AAS52453.2 - 1.2e-05 24.7 0.0 0.0016 17.7 0.0 2.2 1 1 0 2 2 2 1 G-protein alpha subunit GTP_EFTU PF00009.27 AAS52453.2 - 0.0011 18.5 0.0 0.15 11.6 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AAS52453.2 - 0.0045 16.4 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AAS52453.2 - 0.0047 16.4 0.0 0.0074 15.7 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AAS52453.2 - 0.0091 15.5 0.0 0.024 14.2 0.0 1.8 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_24 PF13479.6 AAS52453.2 - 0.037 13.7 0.1 0.096 12.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS52453.2 - 0.13 12.7 0.0 0.23 12.0 0.0 1.3 1 0 0 1 1 1 0 ABC transporter Dynamin_N PF00350.23 AAS52453.2 - 0.17 11.9 0.0 0.57 10.2 0.0 1.7 2 0 0 2 2 2 0 Dynamin family DUF2470 PF10615.9 AAS52454.1 - 2.5e-13 50.4 0.1 4.8e-13 49.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2470) Pkinase PF00069.25 AAS52455.1 - 1.1e-75 254.4 0.1 1.6e-75 253.9 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain AdenylateSensor PF16579.5 AAS52455.1 - 8.1e-58 194.0 0.1 2.1e-57 192.6 0.1 1.8 1 0 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Pkinase_Tyr PF07714.17 AAS52455.1 - 5.1e-38 130.8 0.0 7.4e-38 130.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UBA_2 PF08587.11 AAS52455.1 - 1.2e-17 63.8 1.1 1.2e-17 63.8 1.1 2.2 2 0 0 2 2 2 1 Ubiquitin associated domain (UBA) Kinase-like PF14531.6 AAS52455.1 - 5.4e-10 39.1 0.0 1.8e-09 37.3 0.0 1.8 1 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 AAS52455.1 - 0.00015 21.4 0.7 0.00028 20.6 0.7 1.4 1 0 0 1 1 1 1 RIO1 family YukC PF10140.9 AAS52455.1 - 0.00019 20.4 0.6 0.00029 19.8 0.6 1.2 1 0 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukC Haspin_kinase PF12330.8 AAS52455.1 - 0.00035 19.6 0.5 0.00057 18.9 0.5 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AAS52455.1 - 0.0032 16.9 0.2 0.0063 15.9 0.2 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family ABC1 PF03109.16 AAS52455.1 - 0.0074 16.5 0.2 5.4 7.2 0.1 2.4 2 0 0 2 2 2 2 ABC1 family APH PF01636.23 AAS52455.1 - 0.081 12.8 0.6 0.46 10.4 0.3 2.2 2 1 1 3 3 3 0 Phosphotransferase enzyme family SIR2 PF02146.17 AAS52456.2 - 8.4e-38 130.0 0.0 1.2e-36 126.2 0.0 2.3 1 1 0 1 1 1 1 Sir2 family DUF2256 PF10013.9 AAS52456.2 - 0.055 13.6 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Rpr2 PF04032.16 AAS52457.1 - 3.9e-10 39.9 0.4 3.9e-10 39.9 0.4 2.0 2 0 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain PHD_Oberon PF07227.11 AAS52457.1 - 0.021 14.7 0.4 0.044 13.7 0.4 1.5 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein Pex24p PF06398.11 AAS52458.2 - 5.7e-86 288.8 0.4 6.8e-86 288.5 0.4 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin ELMO_CED12 PF04727.13 AAS52458.2 - 0.15 12.2 0.1 0.27 11.3 0.1 1.3 1 0 0 1 1 1 0 ELMO/CED-12 family DUF4282 PF14110.6 AAS52458.2 - 1.7 9.4 5.1 6.6 7.5 2.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) PQQ_3 PF13570.6 AAS52459.1 - 9.8e-07 29.1 1.6 0.98 10.0 0.2 4.6 4 0 0 4 4 4 3 PQQ-like domain WD40 PF00400.32 AAS52459.1 - 1.3e-06 29.0 3.6 0.011 16.6 0.0 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52459.1 - 0.0016 18.7 0.0 3.1 8.1 0.0 3.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain SET PF00856.28 AAS52460.2 - 1.4e-11 45.0 0.0 2.2e-11 44.4 0.0 1.3 1 0 0 1 1 1 1 SET domain TPR_1 PF00515.28 AAS52461.2 - 4.9e-46 152.8 32.5 1.7e-09 37.1 0.1 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 AAS52461.2 - 1.9e-36 121.2 36.6 6.2e-08 32.2 0.1 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat STI1 PF17830.1 AAS52461.2 - 1e-35 121.4 15.7 5.6e-18 64.6 4.6 3.0 3 0 0 3 3 3 2 STI1 domain TPR_12 PF13424.6 AAS52461.2 - 1.9e-21 76.2 21.8 3e-09 37.1 3.0 6.4 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 AAS52461.2 - 4.6e-20 70.1 35.0 8.2e-06 25.6 0.1 8.7 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_16 PF13432.6 AAS52461.2 - 4.6e-19 68.8 23.1 0.00024 21.7 0.0 6.7 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 AAS52461.2 - 1.5e-18 66.2 34.8 0.00013 21.5 1.9 9.2 8 1 1 9 9 9 6 TPR repeat TPR_14 PF13428.6 AAS52461.2 - 4.4e-16 58.2 19.5 0.0017 19.0 0.2 9.0 3 3 6 9 9 9 5 Tetratricopeptide repeat TPR_7 PF13176.6 AAS52461.2 - 5.5e-16 57.3 18.0 9.1e-05 22.2 0.0 8.0 7 1 1 8 8 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 AAS52461.2 - 3.2e-14 53.2 27.7 0.00016 22.1 0.5 6.9 4 3 2 7 7 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 AAS52461.2 - 3e-12 46.0 18.2 0.014 15.2 0.3 7.3 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 AAS52461.2 - 2.1e-11 43.3 9.3 0.13 12.7 0.0 7.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 AAS52461.2 - 4.1e-09 36.5 7.7 0.004 17.3 0.2 5.5 3 3 2 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 AAS52461.2 - 7.5e-08 32.5 23.8 0.92 10.3 0.1 8.6 8 0 0 8 8 8 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS52461.2 - 0.00015 21.9 17.3 0.11 12.7 0.7 5.1 2 2 5 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 AAS52461.2 - 0.00093 19.2 11.7 1.1 9.3 0.1 5.6 6 0 0 6 6 5 1 Fis1 C-terminal tetratricopeptide repeat DUF3808 PF10300.9 AAS52461.2 - 0.0012 17.7 0.2 0.0012 17.7 0.2 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF3808) SHNi-TPR PF10516.9 AAS52461.2 - 0.031 13.7 12.2 7.6 6.1 0.0 6.3 7 0 0 7 7 7 0 SHNi-TPR Rep_Org_C PF06926.11 AAS52461.2 - 0.065 13.5 1.1 13 6.2 0.1 2.8 1 1 0 2 2 2 0 Putative replisome organiser protein C-terminus GerD PF17898.1 AAS52461.2 - 0.081 12.9 5.8 1.8 8.5 0.6 3.5 2 1 0 2 2 2 0 Spore germination GerD central core domain RPN7 PF10602.9 AAS52461.2 - 0.23 11.2 20.0 0.76 9.5 0.0 5.7 3 2 3 6 6 6 0 26S proteasome subunit RPN7 TPR_20 PF14561.6 AAS52461.2 - 1.2 9.5 16.6 0.36 11.2 0.5 5.2 4 3 2 6 6 5 0 Tetratricopeptide repeat Sel1 PF08238.12 AAS52461.2 - 5 7.9 10.9 18 6.2 0.1 4.9 5 0 0 5 5 5 0 Sel1 repeat NSF PF02071.20 AAS52461.2 - 5.8 8.1 6.7 4.5e+02 2.5 0.2 5.6 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.18 AAS52461.2 - 7.7 6.7 25.9 3.6 7.7 0.2 6.8 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain AAA_2 PF07724.14 AAS52462.2 - 5.4e-52 176.3 0.1 9.9e-50 169.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AAS52462.2 - 3.1e-35 120.2 1.2 3.1e-35 120.2 1.2 2.7 1 1 1 2 2 2 1 AAA lid domain ClpB_D2-small PF10431.9 AAS52462.2 - 5.2e-27 93.7 2.5 5.3e-27 93.7 0.1 2.4 2 1 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA PF00004.29 AAS52462.2 - 2.4e-20 73.3 1.1 2.8e-10 40.7 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AAS52462.2 - 3.7e-16 59.4 0.1 1.7e-11 44.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS52462.2 - 2e-10 41.3 2.0 0.00048 20.5 0.1 4.0 2 2 1 3 3 3 2 AAA ATPase domain Sigma54_activat PF00158.26 AAS52462.2 - 5.2e-07 29.5 0.1 3.7e-05 23.5 0.0 2.5 2 1 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 AAS52462.2 - 1.5e-06 28.5 0.2 0.09 13.0 0.0 3.6 3 1 0 3 3 3 2 AAA domain IstB_IS21 PF01695.17 AAS52462.2 - 7.1e-06 25.9 0.0 0.078 12.7 0.0 2.8 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase_2 PF01637.18 AAS52462.2 - 1.8e-05 24.8 7.9 0.24 11.3 0.0 4.4 4 2 0 4 4 3 2 ATPase domain predominantly from Archaea AAA_7 PF12775.7 AAS52462.2 - 1.9e-05 24.2 0.2 0.028 13.9 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_14 PF13173.6 AAS52462.2 - 2.9e-05 24.1 0.0 0.12 12.4 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AAS52462.2 - 6.7e-05 23.4 1.1 0.13 12.8 0.0 3.3 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 AAS52462.2 - 8.3e-05 23.1 0.2 0.14 12.6 0.0 3.0 3 0 0 3 3 2 1 ABC transporter AAA_23 PF13476.6 AAS52462.2 - 8.4e-05 23.2 8.0 0.058 13.9 3.3 3.6 3 1 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 AAS52462.2 - 8.5e-05 22.5 0.1 0.041 13.8 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase TniB PF05621.11 AAS52462.2 - 9.7e-05 21.9 0.0 0.017 14.6 0.0 3.4 2 1 0 2 2 2 1 Bacterial TniB protein AAA_30 PF13604.6 AAS52462.2 - 0.00022 21.0 0.2 1.2 8.8 0.1 3.4 3 1 0 3 3 2 2 AAA domain NACHT PF05729.12 AAS52462.2 - 0.00042 20.3 0.0 0.098 12.6 0.0 2.5 2 0 0 2 2 2 1 NACHT domain TsaE PF02367.17 AAS52462.2 - 0.00048 20.1 0.1 1 9.3 0.0 2.9 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 AAS52462.2 - 0.00052 19.2 0.8 0.51 9.4 0.2 3.6 2 2 0 2 2 2 1 Protein of unknown function (DUF815) Roc PF08477.13 AAS52462.2 - 0.00088 19.5 0.1 1.6 9.0 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 AAS52462.2 - 0.0011 18.3 0.0 0.017 14.4 0.0 2.7 2 1 0 2 2 2 1 Zeta toxin RNA_helicase PF00910.22 AAS52462.2 - 0.0013 19.1 0.0 3.5 8.1 0.0 3.3 3 0 0 3 3 2 1 RNA helicase PduV-EutP PF10662.9 AAS52462.2 - 0.0014 18.4 0.0 0.26 11.0 0.0 2.6 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_29 PF13555.6 AAS52462.2 - 0.0016 18.1 0.0 0.39 10.5 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_28 PF13521.6 AAS52462.2 - 0.0024 18.1 0.0 0.79 10.0 0.0 3.0 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AAS52462.2 - 0.0028 17.1 0.1 0.74 9.2 0.0 3.2 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 AAS52462.2 - 0.0055 17.1 1.0 8 6.8 0.2 4.3 3 2 0 4 4 4 0 AAA domain Torsin PF06309.11 AAS52462.2 - 0.0086 16.2 0.0 0.043 13.9 0.0 2.0 2 0 0 2 2 2 1 Torsin DUF87 PF01935.17 AAS52462.2 - 0.011 15.9 2.9 1.4 9.0 0.0 3.5 3 0 0 3 3 3 0 Helicase HerA, central domain T2SSE PF00437.20 AAS52462.2 - 0.017 14.2 0.1 0.15 11.1 0.0 2.3 2 1 0 2 2 2 0 Type II/IV secretion system protein AAA_6 PF12774.7 AAS52462.2 - 0.02 13.9 0.5 0.26 10.2 0.0 2.8 4 0 0 4 4 4 0 Hydrolytic ATP binding site of dynein motor region SRP54 PF00448.22 AAS52462.2 - 0.023 14.3 0.0 6.2 6.4 0.0 2.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ResIII PF04851.15 AAS52462.2 - 0.028 14.4 0.0 1.3 9.0 0.0 3.2 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.17 AAS52462.2 - 0.033 14.0 0.0 3.3 7.4 0.0 2.6 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein PilJ PF13675.6 AAS52462.2 - 0.037 14.1 2.3 0.5 10.4 0.5 2.9 3 0 0 3 3 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term AAA_21 PF13304.6 AAS52462.2 - 0.047 13.5 1.8 10 5.8 0.0 3.7 3 1 1 4 4 4 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 AAS52462.2 - 0.061 13.4 0.4 6.5 6.9 0.0 3.4 3 2 0 3 3 3 0 50S ribosome-binding GTPase AAA_25 PF13481.6 AAS52462.2 - 0.062 12.9 0.2 1.5 8.3 0.0 2.8 3 0 0 3 3 2 0 AAA domain NTPase_1 PF03266.15 AAS52462.2 - 0.078 12.9 0.3 35 4.3 0.0 3.4 3 0 0 3 3 3 0 NTPase AAA_24 PF13479.6 AAS52462.2 - 0.079 12.7 0.0 11 5.6 0.0 2.5 2 0 0 2 2 2 0 AAA domain bZIP_1 PF00170.21 AAS52463.1 - 1.1e-08 35.0 16.7 1.1e-08 35.0 16.7 2.6 2 1 0 2 2 2 1 bZIP transcription factor FAM199X PF15814.5 AAS52463.1 - 0.00016 20.9 0.1 0.00019 20.6 0.1 1.2 1 0 0 1 1 1 1 Protein family FAM199X bZIP_Maf PF03131.17 AAS52463.1 - 0.013 16.0 8.3 0.047 14.2 8.4 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor NYD-SP28_assoc PF14775.6 AAS52463.1 - 0.014 15.5 2.1 0.028 14.5 2.1 1.5 1 0 0 1 1 1 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 AAS52463.1 - 0.25 11.5 17.9 1.2 9.3 5.4 2.4 1 1 1 2 2 2 0 Basic region leucine zipper Cep57_CLD_2 PF14197.6 AAS52463.1 - 0.82 9.8 7.7 1.5 8.9 7.7 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Cellulase PF00150.18 AAS52465.1 - 9.3e-13 48.2 1.8 2.3e-12 47.0 1.4 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) PalH PF08733.10 AAS52466.1 - 4.9e-83 278.9 9.9 5.8e-83 278.6 9.9 1.0 1 0 0 1 1 1 1 PalH/RIM21 DUF2142 PF09913.9 AAS52466.1 - 1.9 7.2 18.2 0.048 12.5 9.6 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2142) Dna2 PF08696.11 AAS52467.1 - 1.3e-57 194.9 0.3 6.6e-57 192.6 0.2 2.2 2 0 0 2 2 2 1 DNA replication factor Dna2 AAA_12 PF13087.6 AAS52467.1 - 1.5e-47 161.8 0.0 4.6e-47 160.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_11 PF13086.6 AAS52467.1 - 1.6e-32 113.4 0.0 2e-16 60.6 0.0 3.0 2 1 1 3 3 3 2 AAA domain AAA_30 PF13604.6 AAS52467.1 - 5.3e-14 52.4 0.0 1.8e-13 50.7 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AAS52467.1 - 1.7e-10 41.4 0.0 1.3e-09 38.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain Cas_Cas4 PF01930.17 AAS52467.1 - 3.3e-06 27.3 0.1 0.0012 19.0 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.18 AAS52467.1 - 3.3e-06 27.0 0.1 0.22 11.2 0.0 3.7 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PDDEXK_1 PF12705.7 AAS52467.1 - 0.00019 21.4 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Helicase_RecD PF05127.14 AAS52467.1 - 0.00035 20.5 0.0 0.0012 18.7 0.0 2.0 1 0 0 1 1 1 1 Helicase AAA_16 PF13191.6 AAS52467.1 - 0.00072 20.0 0.0 0.002 18.5 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain SRP54 PF00448.22 AAS52467.1 - 0.003 17.2 0.0 0.0095 15.6 0.0 1.9 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 AAS52467.1 - 0.0038 17.5 0.2 0.017 15.4 0.1 2.2 2 0 0 2 2 1 1 AAA domain CbiA PF01656.23 AAS52467.1 - 0.0044 17.1 0.0 0.012 15.7 0.0 1.7 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain NTPase_1 PF03266.15 AAS52467.1 - 0.0053 16.7 0.1 0.059 13.3 0.1 2.4 2 0 0 2 2 2 1 NTPase PhoH PF02562.16 AAS52467.1 - 0.006 16.1 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein ResIII PF04851.15 AAS52467.1 - 0.01 15.8 0.1 0.03 14.3 0.1 1.8 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit MobB PF03205.14 AAS52467.1 - 0.017 15.0 0.1 0.048 13.6 0.1 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B PIF1 PF05970.14 AAS52467.1 - 0.025 13.8 0.0 0.053 12.7 0.0 1.4 1 1 0 1 1 1 0 PIF1-like helicase T2SSE PF00437.20 AAS52467.1 - 0.029 13.5 0.0 0.063 12.3 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 AAS52467.1 - 0.031 14.2 0.0 0.097 12.6 0.0 1.9 1 0 0 1 1 1 0 NACHT domain UvrD-helicase PF00580.21 AAS52467.1 - 0.035 13.6 0.3 0.15 11.6 0.0 2.1 2 1 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_5 PF07728.14 AAS52467.1 - 0.037 14.0 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 AAS52467.1 - 0.04 14.4 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AAS52467.1 - 0.048 14.2 0.0 0.18 12.3 0.0 2.0 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AAS52467.1 - 0.065 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DnaB_C PF03796.15 AAS52467.1 - 0.079 12.3 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain cobW PF02492.19 AAS52467.1 - 0.081 12.5 0.0 0.26 10.9 0.0 1.8 2 0 0 2 2 1 0 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 AAS52467.1 - 0.081 11.9 0.0 0.16 10.9 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 AAS52467.1 - 0.084 13.4 0.0 0.38 11.3 0.0 2.2 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 AAS52467.1 - 0.097 12.0 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI UvrD_C_2 PF13538.6 AAS52467.1 - 0.1 12.4 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_33 PF13671.6 AAS52467.1 - 0.13 12.4 0.0 0.35 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.22 AAS52468.1 - 2.4e-36 123.4 0.0 6.4e-15 54.7 0.0 5.3 4 1 1 5 5 5 5 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 AAS52468.1 - 0.072 13.1 0.0 5.8 7.0 0.0 3.2 3 0 0 3 3 3 0 RNA binding domain RRM_7 PF16367.5 AAS52468.1 - 0.18 12.0 0.4 21 5.3 0.0 3.6 3 1 0 3 3 3 0 RNA recognition motif HSF_DNA-bind PF00447.17 AAS52469.1 - 1.3e-21 77.0 0.0 2.4e-21 76.2 0.0 1.4 1 0 0 1 1 1 1 HSF-type DNA-binding Glucosamine_iso PF01182.20 AAS52470.1 - 2.2e-61 207.6 0.3 2.8e-61 207.3 0.3 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase CPDase PF07823.11 AAS52471.1 - 2e-80 269.2 0.0 2.2e-80 269.0 0.0 1.0 1 0 0 1 1 1 1 Cyclic phosphodiesterase-like protein 2_5_RNA_ligase2 PF13563.6 AAS52471.1 - 0.01 15.8 0.4 0.18 11.7 0.3 2.1 1 1 1 2 2 2 0 2'-5' RNA ligase superfamily TFIIB PF00382.19 AAS52472.1 - 5e-57 189.9 1.0 3.6e-28 97.4 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 AAS52472.1 - 2.9e-30 104.6 1.3 2.9e-30 104.6 1.3 2.9 2 1 1 3 3 3 1 Brf1-like TBP-binding domain TF_Zn_Ribbon PF08271.12 AAS52472.1 - 8.8e-13 47.6 2.4 1.6e-12 46.7 2.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_N PF00134.23 AAS52472.1 - 0.00026 20.7 0.3 0.15 11.8 0.1 2.4 2 0 0 2 2 2 2 Cyclin, N-terminal domain Zn-ribbon_8 PF09723.10 AAS52472.1 - 0.032 14.3 0.7 0.073 13.2 0.7 1.6 1 0 0 1 1 1 0 Zinc ribbon domain A2L_zn_ribbon PF08792.10 AAS52472.1 - 0.09 12.5 1.8 0.18 11.5 1.8 1.5 1 0 0 1 1 1 0 A2L zinc ribbon domain MFMR_assoc PF16596.5 AAS52472.1 - 1.4 9.4 5.9 7.9 6.9 5.7 2.3 2 0 0 2 2 2 0 Disordered region downstream of MFMR SDA1 PF05285.12 AAS52473.1 - 9.2e-85 285.1 31.1 4.7e-43 147.9 3.5 3.1 2 1 1 3 3 3 3 SDA1 NUC130_3NT PF08158.12 AAS52473.1 - 5e-21 74.8 0.1 1.2e-20 73.5 0.1 1.7 1 0 0 1 1 1 1 NUC130/3NT domain ATP-grasp_2 PF08442.10 AAS52474.1 - 2.1e-73 246.2 0.9 3.7e-73 245.4 0.9 1.4 1 0 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 AAS52474.1 - 3.5e-25 88.6 0.1 3.5e-25 88.6 0.1 2.5 3 1 0 3 3 3 1 CoA-ligase ATP-grasp_5 PF13549.6 AAS52474.1 - 5.8e-10 39.0 0.8 1e-09 38.2 0.8 1.3 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.19 AAS52474.1 - 0.006 16.4 0.1 0.02 14.7 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain CPSase_L_D2 PF02786.17 AAS52474.1 - 0.0093 15.5 0.1 0.023 14.2 0.1 1.7 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain MPC PF03650.13 AAS52475.1 - 4.7e-48 161.9 0.0 5.2e-48 161.8 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers ANTH PF07651.16 AAS52476.1 - 5.3e-59 199.5 0.7 5.3e-59 199.5 0.7 2.0 2 0 0 2 2 2 1 ANTH domain ENTH PF01417.20 AAS52476.1 - 1.5e-05 25.0 1.4 3.8e-05 23.7 0.0 2.3 2 1 0 2 2 2 1 ENTH domain ABC_transp_aux PF09822.9 AAS52476.1 - 0.49 9.8 8.3 1.2 8.6 7.7 1.8 2 0 0 2 2 2 0 ABC-type uncharacterized transport system PFK PF00365.20 AAS52477.1 - 9.5e-185 612.5 2.9 5e-105 350.9 0.6 2.1 2 0 0 2 2 2 2 Phosphofructokinase Pfk_N PF18468.1 AAS52477.1 - 2.2e-25 89.0 0.1 4.7e-25 87.9 0.1 1.6 1 0 0 1 1 1 1 Phosphofructokinase N-terminal domain yeast DAGK_cat PF00781.24 AAS52477.1 - 0.00097 18.8 0.1 0.029 14.0 0.1 2.7 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain NTP_transf_2 PF01909.23 AAS52478.1 - 4.6e-18 65.3 0.0 2.3e-17 63.1 0.0 2.2 2 0 0 2 2 2 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 AAS52478.1 - 2.2e-15 56.6 0.0 6.1e-15 55.2 0.0 1.8 1 0 0 1 1 1 1 Cid1 family poly A polymerase Polbeta PF18765.1 AAS52478.1 - 0.038 14.1 0.0 0.098 12.8 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase RF-1 PF00472.20 AAS52479.1 - 1.8e-19 69.8 0.3 2.4e-19 69.4 0.3 1.2 1 0 0 1 1 1 1 RF-1 domain Phage_Nu1 PF07471.12 AAS52479.1 - 0.0089 15.8 2.5 0.014 15.2 2.5 1.3 1 0 0 1 1 1 1 Phage DNA packaging protein Nu1 HAD_SAK_2 PF18143.1 AAS52479.1 - 0.06 13.7 1.0 0.08 13.3 0.6 1.4 1 1 0 1 1 1 0 HAD domain in Swiss Army Knife RNA repair proteins Pkinase PF00069.25 AAS52480.1 - 1.6e-65 221.1 0.7 1.3e-64 218.1 0.2 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52480.1 - 1.3e-50 172.1 0.0 1.9e-50 171.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PBD PF00786.28 AAS52480.1 - 7.5e-23 80.6 0.3 1.7e-22 79.5 0.3 1.6 1 0 0 1 1 1 1 P21-Rho-binding domain PH PF00169.29 AAS52480.1 - 2.3e-10 40.9 0.0 4e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 AAS52480.1 - 1.2e-06 28.1 0.0 2e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AAS52480.1 - 5.5e-06 25.4 0.0 8.6e-06 24.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 AAS52480.1 - 0.01 15.8 0.3 0.044 13.7 0.3 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family PH_11 PF15413.6 AAS52480.1 - 0.016 15.6 0.0 0.046 14.1 0.0 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain DCB PF16213.5 AAS52481.1 - 7.9e-47 159.2 12.6 2.3e-46 157.7 2.2 3.9 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 Sec7_N PF12783.7 AAS52481.1 - 4.4e-34 117.7 22.2 4.3e-33 114.5 10.2 5.1 5 0 0 5 5 5 2 Guanine nucleotide exchange factor in Golgi transport N-terminal Mon2_C PF16206.5 AAS52481.1 - 1.6e-11 43.1 0.1 1.1e-07 30.4 0.0 2.7 2 1 0 2 2 2 2 C-terminal region of Mon2 protein JHD PF17811.1 AAS52481.1 - 0.076 13.6 0.5 0.55 10.8 0.0 2.8 3 0 0 3 3 3 0 Jumonji helical domain PalH PF08733.10 AAS52483.1 - 2.5e-80 270.0 0.9 3.1e-80 269.7 0.9 1.1 1 0 0 1 1 1 1 PalH/RIM21 DUF4131 PF13567.6 AAS52483.1 - 2.5 7.7 6.8 0.35 10.5 0.3 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) RabGAP-TBC PF00566.18 AAS52484.1 - 2.9e-43 148.0 0.2 5.4e-43 147.2 0.2 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Get5_bdg PF16843.5 AAS52485.1 - 5.9e-24 83.3 0.9 9.5e-24 82.7 0.9 1.3 1 0 0 1 1 1 1 Binding domain to Get4 on Get5, Golgi to ER traffic protein Get5_C PF18514.1 AAS52485.1 - 4.7e-09 35.8 1.4 3.3e-08 33.1 0.1 2.7 3 0 0 3 3 3 1 Get5 C-terminal domain ubiquitin PF00240.23 AAS52485.1 - 1.7e-05 24.5 0.0 2.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 AAS52485.1 - 0.005 17.4 0.0 0.0089 16.6 0.0 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 AAS52485.1 - 0.071 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Erf4 PF10256.9 AAS52486.2 - 5.5e-34 116.7 0.0 7.2e-34 116.4 0.0 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 7/ERF4 family TruB_N PF01509.18 AAS52487.1 - 1.3e-39 135.9 0.1 5.1e-38 130.8 0.0 2.3 1 1 0 2 2 2 1 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AAS52487.1 - 6.1e-06 26.3 0.0 1.5e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain Mid1 PF12929.7 AAS52488.2 - 3.1e-123 412.1 5.3 4.1e-123 411.7 5.3 1.1 1 0 0 1 1 1 1 Stretch-activated Ca2+-permeable channel component Fz PF01392.22 AAS52488.2 - 6e-05 23.6 6.5 0.0011 19.5 0.8 2.6 2 0 0 2 2 2 2 Fz domain AAA PF00004.29 AAS52489.1 - 6.9e-18 65.3 0.0 1.1e-17 64.7 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AAS52489.1 - 8.7e-17 61.4 0.0 1.2e-13 51.1 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit Rep_fac_C PF08542.11 AAS52489.1 - 3.7e-15 56.1 0.0 1.4e-14 54.2 0.0 2.0 2 0 0 2 2 1 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 AAS52489.1 - 3.7e-08 33.6 0.1 1.1e-07 32.0 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain Rad17 PF03215.15 AAS52489.1 - 1.9e-07 31.2 0.0 5e-07 29.8 0.0 1.7 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 AAS52489.1 - 4.9e-07 30.3 0.6 1.8e-06 28.5 0.6 2.2 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 AAS52489.1 - 3.4e-06 26.9 0.0 7.2e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta PF06144.13 AAS52489.1 - 6.4e-06 26.1 0.1 9.9e-06 25.4 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit ResIII PF04851.15 AAS52489.1 - 1.8e-05 24.8 0.0 0.005 16.9 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 AAS52489.1 - 2.5e-05 24.1 0.1 0.00068 19.4 0.0 2.8 3 1 0 3 3 3 1 AAA domain DUF815 PF05673.13 AAS52489.1 - 2.8e-05 23.4 0.0 4.3e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 AAS52489.1 - 4.6e-05 23.7 0.6 0.023 15.0 0.6 2.5 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AAS52489.1 - 5.6e-05 23.1 0.0 0.0002 21.3 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AAS52489.1 - 7e-05 22.9 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AAS52489.1 - 0.00028 20.9 0.0 0.0013 18.7 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 AAS52489.1 - 0.00035 20.4 0.0 0.00068 19.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AAS52489.1 - 0.00041 20.1 0.0 0.00088 19.1 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_3 PF07726.11 AAS52489.1 - 0.0011 18.9 0.0 0.0019 18.0 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 AAS52489.1 - 0.0014 18.2 0.0 0.0033 16.9 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region DEAD PF00270.29 AAS52489.1 - 0.0017 18.2 0.1 0.0062 16.3 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_19 PF13245.6 AAS52489.1 - 0.0034 17.7 1.5 0.34 11.3 0.0 3.0 2 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 AAS52489.1 - 0.0056 17.2 0.0 0.012 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 AAS52489.1 - 0.013 14.9 0.0 0.24 10.8 0.0 2.1 1 1 1 2 2 2 0 Bacterial TniB protein Mg_chelatase PF01078.21 AAS52489.1 - 0.017 14.5 0.0 0.092 12.1 0.0 2.0 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI HMG-CoA_red PF00368.18 AAS52489.1 - 0.019 14.0 0.0 0.029 13.4 0.0 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase RNA_helicase PF00910.22 AAS52489.1 - 0.021 15.2 0.0 0.039 14.4 0.0 1.5 1 1 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 AAS52489.1 - 0.022 14.9 0.2 0.069 13.3 0.2 2.0 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 AAS52489.1 - 0.022 14.5 0.0 0.033 13.9 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TIP49 PF06068.13 AAS52489.1 - 0.03 13.5 0.0 0.044 13.0 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 AAS52489.1 - 0.039 14.2 0.0 0.13 12.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AAS52489.1 - 0.047 13.3 1.1 0.56 9.8 0.0 2.7 2 1 1 3 3 3 0 AAA domain SRP54 PF00448.22 AAS52489.1 - 0.065 12.9 0.0 0.13 11.9 0.0 1.6 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain ATPase_2 PF01637.18 AAS52489.1 - 0.087 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea PIF1 PF05970.14 AAS52489.1 - 0.091 11.9 0.0 3.3 6.8 0.0 2.1 2 0 0 2 2 2 0 PIF1-like helicase SNF2_N PF00176.23 AAS52489.1 - 0.097 11.4 0.0 0.14 10.9 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain DUF2075 PF09848.9 AAS52489.1 - 0.12 11.6 0.0 0.31 10.2 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) TPR_6 PF13174.6 AAS52489.1 - 0.29 11.9 2.4 37 5.2 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Cyclin_N PF00134.23 AAS52490.1 - 3.9e-18 65.4 0.0 4.6e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AAS52490.1 - 1e-07 32.5 0.0 1.5e-07 31.9 0.0 1.3 1 0 0 1 1 1 1 Cyclin Rcd1 PF04078.13 AAS52491.1 - 3.5e-116 387.0 4.6 4.1e-116 386.8 4.6 1.0 1 0 0 1 1 1 1 Cell differentiation family, Rcd1-like Adaptin_N PF01602.20 AAS52492.1 - 3.4e-107 359.2 11.5 4.5e-107 358.8 11.5 1.2 1 0 0 1 1 1 1 Adaptin N terminal region COP-gamma_platf PF08752.10 AAS52492.1 - 1.5e-47 161.5 1.3 2e-47 161.1 0.0 1.9 2 0 0 2 2 2 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 AAS52492.1 - 2.5e-28 98.5 0.1 5.7e-28 97.4 0.1 1.7 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform HEAT_2 PF13646.6 AAS52492.1 - 1.9e-11 44.2 0.0 0.0002 21.7 0.0 5.0 3 2 1 4 4 4 2 HEAT repeats HEAT PF02985.22 AAS52492.1 - 4.1e-06 26.6 2.0 3.1 8.3 0.0 6.4 6 0 0 6 6 6 1 HEAT repeat Cnd1 PF12717.7 AAS52492.1 - 0.0027 17.8 13.3 0.38 10.8 0.9 5.4 3 1 1 5 5 5 1 non-SMC mitotic condensation complex subunit 1 ATPase PF06745.13 AAS52492.1 - 0.005 16.2 0.0 0.02 14.2 0.1 2.0 2 0 0 2 2 2 1 KaiC DUF2780 PF11075.8 AAS52492.1 - 0.011 15.9 0.1 0.027 14.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) HEAT_EZ PF13513.6 AAS52492.1 - 0.013 16.0 0.4 13 6.4 0.0 3.9 4 1 0 4 4 4 0 HEAT-like repeat EPO_TPO PF00758.18 AAS52492.1 - 0.41 10.7 3.1 0.42 10.6 0.1 2.7 3 0 0 3 3 3 0 Erythropoietin/thrombopoietin YchF-GTPase_C PF06071.13 AAS52493.1 - 9.9e-37 125.0 0.2 3.2e-36 123.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 AAS52493.1 - 4.8e-17 62.1 0.0 1.5e-16 60.5 0.0 1.8 1 1 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS52493.1 - 0.0076 15.8 0.0 0.016 14.7 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B TGS PF02824.21 AAS52493.1 - 0.041 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 TGS domain SecA_PP_bind PF01043.20 AAS52493.1 - 0.17 12.6 0.6 2.1 9.1 0.0 2.3 2 0 0 2 2 2 0 SecA preprotein cross-linking domain SCO1-SenC PF02630.14 AAS52494.2 - 7.2e-50 168.4 0.0 1.1e-49 167.8 0.0 1.3 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 AAS52494.2 - 0.0087 16.0 0.0 0.014 15.3 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family B12-binding PF02310.19 AAS52494.2 - 0.16 12.0 0.0 0.57 10.2 0.0 1.8 2 0 0 2 2 2 0 B12 binding domain Chitin_synth_1 PF01644.17 AAS52495.1 - 4.4e-71 238.1 1.0 6.7e-71 237.5 1.0 1.3 1 0 0 1 1 1 1 Chitin synthase Chitin_synth_2 PF03142.15 AAS52495.1 - 4.2e-25 88.4 2.4 6.6e-18 64.6 0.0 3.1 3 0 0 3 3 3 3 Chitin synthase Chitin_synth_1N PF08407.11 AAS52495.1 - 1.1e-18 67.0 0.1 2.3e-18 65.9 0.1 1.6 1 0 0 1 1 1 1 Chitin synthase N-terminal Glyco_trans_2_3 PF13632.6 AAS52495.1 - 1.1e-07 32.0 0.9 1.1e-07 32.0 0.9 2.3 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AAS52495.1 - 1.6e-05 24.9 0.0 5.3e-05 23.2 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AAS52496.2 - 8.7e-281 932.1 0.1 1.3e-280 931.5 0.1 1.2 1 0 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AAS52496.2 - 7.3e-13 48.9 0.7 3e-12 46.9 0.7 2.1 1 1 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AAS52496.2 - 1e-11 45.2 0.0 3.9e-10 40.0 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AAS52496.2 - 0.00026 20.5 0.0 0.0021 17.5 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glycos_transf_2 PF00535.26 AAS52496.2 - 0.0012 18.7 0.0 0.034 13.9 0.0 2.5 2 0 0 2 2 2 1 Glycosyl transferase family 2 SHMT PF00464.19 AAS52497.1 - 6.3e-201 667.1 0.0 7.4e-201 666.9 0.0 1.0 1 0 0 1 1 1 1 Serine hydroxymethyltransferase UreE_N PF02814.15 AAS52497.1 - 0.16 11.6 0.1 13 5.4 0.1 2.5 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain Ras PF00071.22 AAS52498.1 - 1.2e-41 142.1 0.2 5.8e-41 139.8 0.2 1.8 1 1 0 1 1 1 1 Ras family Roc PF08477.13 AAS52498.1 - 1.7e-33 115.4 0.2 2.2e-33 115.0 0.2 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS52498.1 - 3.6e-17 62.4 0.2 8.6e-17 61.1 0.1 1.5 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AAS52498.1 - 1.8e-07 31.2 0.0 2.6e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AAS52498.1 - 3.4e-05 23.3 0.0 4.7e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 AAS52498.1 - 5.9e-05 22.7 0.1 0.0014 18.2 0.1 2.2 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS52498.1 - 0.00015 21.7 0.0 0.31 10.9 0.0 2.4 2 1 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 AAS52498.1 - 0.0052 16.2 0.0 0.0076 15.7 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 AAS52498.1 - 0.035 14.1 0.0 0.053 13.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AAA_16 PF13191.6 AAS52498.1 - 0.041 14.3 0.1 0.053 13.9 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 AAS52498.1 - 0.041 13.0 0.2 0.5 9.5 0.2 2.1 1 1 1 2 2 2 0 G-protein alpha subunit TniB PF05621.11 AAS52498.1 - 0.083 12.3 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Rif1_N PF12231.8 AAS52499.1 - 9e-38 130.2 9.9 1.8e-37 129.2 9.9 1.4 1 0 0 1 1 1 1 Rap1-interacting factor 1 N terminal Pkinase PF00069.25 AAS52500.1 - 1.6e-56 191.6 0.0 2e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52500.1 - 2.1e-30 105.9 0.0 2.8e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52500.1 - 7e-05 22.3 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AAS52500.1 - 7.9e-05 21.6 0.0 0.00012 21.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 AAS52500.1 - 0.0077 16.2 2.4 0.14 12.1 0.1 3.0 1 1 2 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 AAS52500.1 - 0.043 13.4 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Kdo PF06293.14 AAS52500.1 - 0.051 12.9 0.0 0.09 12.1 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 AAS52500.1 - 0.054 12.5 0.0 0.085 11.9 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 UBX PF00789.20 AAS52501.1 - 2.1e-14 53.5 0.0 3.2e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 UBX domain ssDBP_DBD PF18361.1 AAS52501.1 - 0.029 14.5 0.1 0.053 13.6 0.1 1.4 1 0 0 1 1 1 0 Single stranded DNA-binding protein ss DNA binding domain Snf7 PF03357.21 AAS52502.2 - 8.4e-14 51.5 3.0 1.2e-13 51.1 3.0 1.1 1 0 0 1 1 1 1 Snf7 Phasin_2 PF09361.10 AAS52502.2 - 0.015 15.5 0.4 0.048 13.9 0.4 1.8 1 0 0 1 1 1 0 Phasin protein Baculo_PEP_C PF04513.12 AAS52502.2 - 0.22 11.6 3.8 1 9.4 1.1 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus COG2 PF06148.11 AAS52502.2 - 4.7 7.3 7.4 7.5 6.7 0.1 3.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 HSM3_N PF18795.1 AAS52503.1 - 1.7e-59 201.2 3.4 2.5e-59 200.6 3.4 1.3 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, N terminal domain HSM3_C PF18794.1 AAS52503.1 - 4.3e-56 189.3 1.4 4.3e-56 189.3 1.4 2.3 3 0 0 3 3 3 1 DNA mismatch repair protein HSM3, C terminal domain Mnd1 PF03962.15 AAS52503.1 - 0.0034 17.7 0.1 0.58 10.5 0.0 2.7 2 0 0 2 2 2 1 Mnd1 HTH domain Cnd3 PF12719.7 AAS52503.1 - 0.004 16.4 0.2 0.021 14.1 0.0 2.1 1 1 1 2 2 2 1 Nuclear condensing complex subunits, C-term domain rRNA_proc-arch PF13234.6 AAS52504.2 - 1.3e-82 277.8 1.7 1.3e-82 277.8 1.7 2.2 2 0 0 2 2 2 1 rRNA-processing arch domain DSHCT PF08148.12 AAS52504.2 - 9.3e-53 178.2 0.6 2.7e-52 176.7 0.6 1.8 1 0 0 1 1 1 1 DSHCT (NUC185) domain DEAD PF00270.29 AAS52504.2 - 8.4e-19 68.0 0.0 6.4e-17 61.9 0.0 3.0 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52504.2 - 1.8e-06 28.2 0.0 1.7e-05 25.1 0.0 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52504.2 - 0.0013 18.8 0.1 0.0066 16.5 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS52504.2 - 0.033 14.4 0.0 0.14 12.4 0.0 2.2 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AAS52504.2 - 0.05 12.6 0.0 0.12 11.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Sh_2 PF17512.2 AAS52505.1 - 0.2 11.4 1.4 0.43 10.3 1.4 1.5 1 0 0 1 1 1 0 Metapneumovirus Small hydrophobic protein Pkinase PF00069.25 AAS52506.1 - 4.1e-35 121.4 0.0 9.6e-35 120.2 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52506.1 - 2.5e-17 63.0 0.0 3e-17 62.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 AAS52506.1 - 4.2e-06 26.5 0.0 6.3e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 AAS52506.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AAS52506.1 - 0.00022 21.3 0.2 0.00046 20.2 0.2 1.5 1 1 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AAS52506.1 - 0.0037 16.1 0.1 0.051 12.4 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 AAS52506.1 - 0.0038 16.6 0.3 0.0087 15.4 0.3 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Vps26 PF03643.15 AAS52507.1 - 2e-112 374.7 0.2 2.3e-112 374.5 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 AAS52507.1 - 0.00028 21.0 0.3 0.033 14.2 0.2 2.9 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Imm19 PF15563.6 AAS52507.1 - 0.014 15.0 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Immunity protein 19 Arrestin_C PF02752.22 AAS52507.1 - 0.1 13.1 0.1 1.4 9.4 0.0 2.4 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain Tim54 PF11711.8 AAS52508.2 - 1.1e-122 409.4 0.0 1.4e-122 409.2 0.0 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF2271 PF10029.9 AAS52508.2 - 0.12 12.0 0.9 0.27 10.9 0.9 1.5 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2271) DUF2797 PF10977.8 AAS52508.2 - 0.15 11.9 0.7 0.35 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2797) Myb_DNA-binding PF00249.31 AAS52509.1 - 3.3e-23 81.6 3.1 1e-13 51.2 0.2 2.3 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS52509.1 - 2.3e-20 72.6 3.2 1.9e-15 56.8 0.1 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 AAS52509.1 - 0.0047 16.9 0.1 0.023 14.7 0.0 2.2 2 1 0 2 2 2 1 SLIDE Myb_DNA-bind_7 PF15963.5 AAS52509.1 - 0.039 13.8 0.1 0.59 10.1 0.0 2.2 1 1 1 2 2 2 0 Myb DNA-binding like Rap1_C PF11626.8 AAS52509.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain Lysine_decarbox PF03641.14 AAS52510.1 - 1.3e-43 148.2 0.0 1.7e-43 147.9 0.0 1.1 1 0 0 1 1 1 1 Possible lysine decarboxylase LDcluster4 PF18306.1 AAS52510.1 - 1.9e-11 43.8 0.0 2.4e-11 43.4 0.0 1.3 1 0 0 1 1 1 1 SLOG cluster4 family zf-H2C2_2 PF13465.6 AAS52511.2 - 6.5e-22 76.9 44.3 1.6e-07 31.4 0.2 7.2 7 0 0 7 7 7 4 Zinc-finger double domain zf-C2H2 PF00096.26 AAS52511.2 - 3.6e-16 58.6 75.6 4.5e-05 23.7 0.9 10.3 10 0 0 10 10 9 5 Zinc finger, C2H2 type Zap1_zf2 PF18217.1 AAS52511.2 - 2e-12 46.9 2.8 2e-12 46.9 2.8 4.7 5 0 0 5 5 5 1 Zap1 zinc finger 2 zf-C2H2_4 PF13894.6 AAS52511.2 - 5.4e-07 29.9 22.4 0.00065 20.3 0.6 11.7 12 0 0 12 12 10 6 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AAS52511.2 - 3.3e-06 27.2 37.7 0.0023 18.2 1.5 7.0 8 0 0 8 8 8 4 Zinc-finger double-stranded RNA-binding FOXP-CC PF16159.5 AAS52511.2 - 6.5e-05 23.5 39.7 0.014 16.0 0.5 7.1 4 2 3 7 7 6 4 FOXP coiled-coil domain zf-C2H2_6 PF13912.6 AAS52511.2 - 0.023 14.7 0.5 0.023 14.7 0.5 6.3 5 1 1 6 6 6 0 C2H2-type zinc finger zf-met PF12874.7 AAS52511.2 - 0.13 12.7 0.2 0.13 12.7 0.2 7.1 7 0 0 7 7 6 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 AAS52511.2 - 0.51 10.3 16.3 4.6 7.2 0.1 5.5 4 0 0 4 4 4 0 zinc-finger of a C2HC-type zf-C2H2_8 PF15909.5 AAS52511.2 - 0.54 10.6 32.2 0.091 13.1 3.2 5.5 3 1 2 5 5 4 0 C2H2-type zinc ribbon zf-C2H2_9 PF16293.5 AAS52511.2 - 1.7 8.6 13.5 0.52 10.2 0.1 4.8 4 1 1 5 5 5 0 C2H2 type zinc-finger (1 copy) DUF2225 PF09986.9 AAS52511.2 - 2.4 7.8 9.6 2 8.1 1.0 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Pkinase PF00069.25 AAS52512.1 - 3.3e-30 105.3 0.0 2.1e-29 102.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52512.1 - 2e-18 66.6 0.0 3.3e-17 62.6 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase DinB_2 PF12867.7 AAS52512.1 - 0.018 15.5 0.0 0.032 14.7 0.0 1.5 1 0 0 1 1 1 0 DinB superfamily FTA2 PF13095.6 AAS52512.1 - 0.038 13.6 0.0 4.4 6.9 0.0 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Complex1_49kDa PF00346.19 AAS52512.1 - 0.039 13.1 0.0 0.064 12.3 0.0 1.3 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit DinB PF05163.12 AAS52512.1 - 0.07 13.0 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 DinB family Zn_Tnp_IS1595 PF12760.7 AAS52512.1 - 0.088 12.8 0.1 0.26 11.3 0.1 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain HbrB PF08539.11 AAS52513.1 - 1.5e-29 103.2 0.2 1.8e-28 99.7 0.2 2.4 1 1 0 1 1 1 1 HbrB-like PglZ PF08665.12 AAS52513.1 - 0.079 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 PglZ domain CLN3 PF02487.17 AAS52514.1 - 3.4e-147 490.7 13.6 3.9e-147 490.5 13.6 1.0 1 0 0 1 1 1 1 CLN3 protein Aminotran_1_2 PF00155.21 AAS52515.1 - 3.9e-75 253.3 0.0 4.7e-75 253.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AAS52515.1 - 0.0078 15.2 0.0 0.063 12.2 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V DegT_DnrJ_EryC1 PF01041.17 AAS52515.1 - 0.016 14.6 0.0 0.037 13.3 0.0 1.5 1 1 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Peptidase_S58 PF03576.14 AAS52515.1 - 0.088 12.3 0.3 0.14 11.6 0.3 1.2 1 0 0 1 1 1 0 Peptidase family S58 Cys_Met_Meta_PP PF01053.20 AAS52515.1 - 0.093 11.2 0.0 0.25 9.8 0.0 1.6 1 1 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme DUF1674 PF07896.12 AAS52516.1 - 2.5e-18 66.3 6.1 1.4e-17 63.9 6.1 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1674) tRNA_deacylase PF04414.12 AAS52516.1 - 0.08 12.5 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase Nup88 PF10168.9 AAS52517.2 - 0.00031 18.7 0.0 0.00031 18.7 0.0 2.0 2 0 0 2 2 2 1 Nuclear pore component TBCA PF02970.16 AAS52517.2 - 0.25 11.7 1.2 1 9.7 1.2 2.0 1 0 0 1 1 1 0 Tubulin binding cofactor A Ribosomal_L37 PF08561.10 AAS52518.1 - 3.7e-21 75.9 7.0 2.8e-16 60.1 0.2 2.1 1 1 1 2 2 2 2 Mitochondrial ribosomal protein L37 Phosphodiest PF01663.22 AAS52519.2 - 7.7e-13 48.8 1.7 7e-09 35.7 0.5 2.2 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AAS52519.2 - 0.00042 19.8 0.2 0.00081 18.8 0.2 1.4 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 AAS52519.2 - 0.014 14.8 0.0 0.039 13.3 0.0 1.7 2 0 0 2 2 2 0 Sulfatase Tmemb_55A PF09788.9 AAS52519.2 - 0.082 12.0 0.2 0.19 10.8 0.2 1.6 1 0 0 1 1 1 0 Transmembrane protein 55A zf-C2H2_2 PF12756.7 AAS52520.1 - 7.5e-37 125.7 6.2 2.4e-34 117.7 1.7 2.6 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) PP_kinase_C PF13090.6 AAS52520.1 - 0.0033 16.9 0.1 0.007 15.8 0.1 1.5 1 0 0 1 1 1 1 Polyphosphate kinase C-terminal domain 2 zf-C2H2_jaz PF12171.8 AAS52520.1 - 0.028 14.7 0.5 0.028 14.7 0.5 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4798 PF16055.5 AAS52520.1 - 0.11 12.7 3.0 0.98 9.7 0.2 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4798) adh_short PF00106.25 AAS52521.1 - 5.2e-21 75.0 0.1 6.8e-21 74.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AAS52521.1 - 3.7e-14 53.1 1.1 4.9e-14 52.6 1.1 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 AAS52521.1 - 1.1e-09 38.2 0.4 1.6e-09 37.7 0.4 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 AAS52521.1 - 0.00036 20.1 0.5 0.0019 17.7 0.5 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 AAS52521.1 - 0.0012 18.0 0.0 0.0041 16.3 0.0 1.8 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Mrpl_C PF18502.1 AAS52523.1 - 3.3e-26 91.7 0.0 6.1e-26 90.9 0.0 1.4 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain Ribosomal_L17 PF01196.19 AAS52523.1 - 4e-26 91.7 0.0 6e-26 91.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L17 Sec16_C PF12931.7 AAS52523.1 - 0.0092 15.7 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 ParE_toxin PF05016.15 AAS52523.1 - 0.05 14.2 2.6 0.74 10.5 0.3 2.9 3 0 0 3 3 3 0 ParE toxin of type II toxin-antitoxin system, parDE RGCC PF15151.6 AAS52523.1 - 0.16 12.2 0.0 0.6 10.3 0.0 1.9 2 1 1 3 3 3 0 Response gene to complement 32 protein family PALP PF00291.25 AAS52524.1 - 9.1e-66 222.2 0.0 1.1e-65 222.0 0.0 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DSPc PF00782.20 AAS52525.1 - 3.9e-21 75.3 0.2 2.9e-19 69.2 0.2 3.0 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AAS52525.1 - 0.00028 20.6 0.5 0.00053 19.6 0.1 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AAS52525.1 - 0.029 14.5 0.2 0.091 12.9 0.1 1.8 2 0 0 2 2 2 0 Inositol hexakisphosphate CBFD_NFYB_HMF PF00808.23 AAS52526.1 - 0.00014 22.1 0.2 0.00028 21.1 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AAS52526.1 - 0.084 13.2 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 MPM1 PF17234.2 AAS52527.2 - 4e-55 186.7 0.2 5.3e-55 186.3 0.2 1.1 1 0 0 1 1 1 1 Mitochondrial peculiar membrane protein 1 Paf1 PF03985.13 AAS52528.2 - 6.7e-97 325.2 12.8 8.3e-97 324.9 12.8 1.0 1 0 0 1 1 1 1 Paf1 Esterase PF00756.20 AAS52529.1 - 1.4e-60 205.1 0.0 1.6e-60 204.9 0.0 1.0 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 AAS52529.1 - 0.17 11.1 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 RCC1_2 PF13540.6 AAS52530.1 - 2.1e-18 65.6 8.9 1.8e-09 37.1 0.2 6.0 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 AAS52530.1 - 6e-17 62.0 2.4 4.3e-05 24.0 0.0 5.6 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat F-box-like PF12937.7 AAS52530.1 - 0.00014 21.6 0.0 0.00031 20.6 0.0 1.6 1 0 0 1 1 1 1 F-box-like Peptidase_M20 PF01546.28 AAS52531.1 - 8.2e-24 84.4 0.0 1.2e-23 83.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AAS52531.1 - 2.5e-08 33.8 0.0 4.3e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain WD40 PF00400.32 AAS52531.1 - 1.2e-06 29.1 11.5 2.2 9.3 0.0 6.7 6 1 0 6 6 6 3 WD domain, G-beta repeat WD40 PF00400.32 AAS52532.1 - 1.5e-11 44.7 2.9 0.003 18.3 0.0 4.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52532.1 - 2.4e-09 37.4 0.0 0.049 13.9 0.0 4.2 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 AAS52532.1 - 0.0052 15.9 0.1 1.1 8.3 0.0 3.1 3 0 0 3 3 3 2 VID27 C-terminal WD40-like domain Ribosomal_S11 PF00411.19 AAS52533.1 - 2.7e-46 156.5 2.2 3.3e-46 156.2 2.2 1.1 1 0 0 1 1 1 1 Ribosomal protein S11 Ribosomal_S8 PF00410.19 AAS52534.1 - 9.5e-24 83.8 0.1 1.5e-23 83.1 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 Ribosomal_L39 PF00832.20 AAS52535.1 - 1.1e-21 76.1 11.5 1.3e-21 75.9 11.5 1.1 1 0 0 1 1 1 1 Ribosomal L39 protein PI_PP_I PF18363.1 AAS52535.1 - 0.0051 17.0 0.1 0.0051 17.0 0.1 1.2 1 0 0 1 1 1 1 Phosphoinositide phosphatase insertion domain Pkinase PF00069.25 AAS52536.1 - 3.8e-47 160.9 0.0 5.7e-47 160.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52536.1 - 6.6e-29 101.0 0.0 9.9e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52536.1 - 0.022 14.1 0.0 0.88 8.8 0.0 2.2 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 AAS52536.1 - 0.061 12.1 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 AAS52536.1 - 0.075 12.9 0.0 1 9.2 0.0 2.2 1 1 0 2 2 2 0 Phosphotransferase enzyme family Mannosyl_trans3 PF11051.8 AAS52537.2 - 5.3e-76 255.6 0.0 7.6e-76 255.1 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Vg_Tdu PF07545.14 AAS52537.2 - 0.042 13.6 0.1 42 4.0 0.0 3.4 3 0 0 3 3 3 0 Vestigial/Tondu family muHD PF10291.9 AAS52538.1 - 1.8e-71 240.7 0.0 2.6e-71 240.2 0.0 1.2 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain SSB PF00436.25 AAS52540.2 - 3e-21 75.4 0.0 3.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Single-strand binding protein family TNT PF14021.6 AAS52540.2 - 0.097 13.2 0.0 0.14 12.8 0.0 1.5 1 1 0 1 1 1 0 Tuberculosis necrotizing toxin Gon7 PF08738.10 AAS52541.1 - 3.5e-41 139.7 0.1 4.1e-41 139.4 0.1 1.0 1 0 0 1 1 1 1 Gon7 family MFS_1 PF07690.16 AAS52542.2 - 1.3e-24 86.8 27.1 2e-24 86.2 27.1 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Glyco_transf_34 PF05637.12 AAS52543.1 - 1e-51 176.0 0.0 1.5e-51 175.4 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family COE1_DBD PF16422.5 AAS52543.1 - 0.11 11.9 0.1 0.2 11.0 0.1 1.4 1 0 0 1 1 1 0 Transcription factor COE1 DNA-binding domain ATP12 PF07542.11 AAS52545.1 - 4.4e-33 114.1 0.0 6.9e-33 113.5 0.0 1.3 1 0 0 1 1 1 1 ATP12 chaperone protein Prefoldin_2 PF01920.20 AAS52546.1 - 1e-20 73.7 4.1 1.1e-20 73.5 4.1 1.0 1 0 0 1 1 1 1 Prefoldin subunit Sipho_Gp157 PF05565.11 AAS52546.1 - 0.0056 16.7 3.1 0.047 13.7 0.9 2.0 2 0 0 2 2 2 1 Siphovirus Gp157 FlxA PF14282.6 AAS52546.1 - 0.021 14.8 6.4 0.61 10.1 1.0 2.3 2 0 0 2 2 2 0 FlxA-like protein GCM PF03615.15 AAS52546.1 - 0.066 13.1 0.0 0.08 12.8 0.0 1.2 1 0 0 1 1 1 0 GCM motif protein RasGAP_C PF03836.15 AAS52546.1 - 0.13 12.4 6.2 0.61 10.2 1.7 2.1 2 0 0 2 2 2 0 RasGAP C-terminus YlqD PF11068.8 AAS52546.1 - 0.19 12.1 5.6 1.1 9.7 1.1 2.1 2 0 0 2 2 2 0 YlqD protein SlyX PF04102.12 AAS52546.1 - 0.36 11.5 4.1 6.4 7.5 0.3 2.5 2 0 0 2 2 2 0 SlyX Caudo_TAP PF02413.17 AAS52546.1 - 0.44 10.7 5.3 0.66 10.1 0.5 2.0 1 1 1 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK Osmo_CC PF08946.10 AAS52546.1 - 0.52 10.6 3.6 4.9 7.5 0.4 2.8 2 1 1 3 3 3 0 Osmosensory transporter coiled coil ATG27 PF09451.10 AAS52547.2 - 1.4e-42 146.4 0.0 1.7e-42 146.1 0.0 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 DUF1344 PF07076.11 AAS52547.2 - 0.13 12.2 1.0 1.9 8.5 1.0 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1344) Ribosomal_L22 PF00237.19 AAS52548.2 - 9.2e-38 128.6 0.1 9.2e-38 128.6 0.1 1.4 2 0 0 2 2 2 1 Ribosomal protein L22p/L17e CASP_C PF08172.12 AAS52549.1 - 2.9e-65 220.1 1.4 2.9e-65 220.1 1.4 4.3 3 2 1 4 4 4 1 CASP C terminal DUF1664 PF07889.12 AAS52549.1 - 0.015 15.3 0.4 0.015 15.3 0.4 5.3 5 1 0 5 5 5 0 Protein of unknown function (DUF1664) ADIP PF11559.8 AAS52549.1 - 0.022 14.8 2.0 0.022 14.8 2.0 6.4 5 2 0 5 5 5 0 Afadin- and alpha -actinin-Binding Pox_A_type_inc PF04508.12 AAS52549.1 - 9.7 6.2 9.7 21 5.2 0.8 4.2 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat SWIRM PF04433.17 AAS52550.2 - 1.1e-28 99.4 0.2 2.1e-28 98.5 0.2 1.5 1 0 0 1 1 1 1 SWIRM domain SWIRM-assoc_1 PF16495.5 AAS52550.2 - 3e-24 84.8 7.2 5.6e-24 83.9 7.2 1.5 1 0 0 1 1 1 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 AAS52550.2 - 1.2e-08 35.0 0.0 2.8e-08 33.8 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS52550.2 - 2.4e-07 30.9 0.0 6.9e-07 29.4 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 AAS52550.2 - 0.053 13.4 2.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 0 Myb DNA-binding like DUF743 PF05332.11 AAS52550.2 - 0.15 12.1 1.0 0.31 11.1 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF743) KRE9 PF05390.11 AAS52551.2 - 9.5e-31 106.6 8.9 1.9e-30 105.6 8.9 1.5 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 AAS52551.2 - 1.2e-07 32.4 0.0 3.4e-07 30.9 0.0 1.8 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family Rep_fac-A_3 PF08661.11 AAS52552.1 - 3.8e-31 107.5 0.0 4.3e-31 107.4 0.0 1.0 1 0 0 1 1 1 1 Replication factor A protein 3 Peptidase_M20 PF01546.28 AAS52553.1 - 8.1e-34 117.1 0.0 1.2e-33 116.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AAS52553.1 - 2.4e-16 59.6 0.0 7.2e-16 58.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain Inhibitor_I48 PF10467.9 AAS52553.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Peptidase inhibitor clitocypin STE3 PF02076.15 AAS52554.1 - 1.5e-78 264.0 18.5 1.8e-78 263.7 18.5 1.1 1 0 0 1 1 1 1 Pheromone A receptor DUF2516 PF10724.9 AAS52554.1 - 2.3 8.6 0.0 2.3 8.6 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF2516) Wzy_C PF04932.15 AAS52554.1 - 8.3 6.0 15.3 0.09 12.4 3.4 2.9 2 2 0 2 2 2 0 O-Antigen ligase DUF2401 PF10287.9 AAS52555.2 - 2.7e-73 246.4 0.0 3.5e-73 246.0 0.0 1.1 1 0 0 1 1 1 1 Putative TOS1-like glycosyl hydrolase (DUF2401) DUF2403 PF10290.9 AAS52555.2 - 6.1e-22 77.8 0.0 1.1e-21 77.0 0.0 1.4 1 0 0 1 1 1 1 Glycine-rich protein domain (DUF2403) SRI PF08236.11 AAS52557.2 - 7.8e-24 83.7 5.4 7.8e-24 83.7 5.4 2.3 2 0 0 2 2 2 1 SRI (Set2 Rpb1 interacting) domain SET PF00856.28 AAS52557.2 - 4.6e-19 69.4 0.3 4.6e-19 69.4 0.3 4.0 3 1 0 3 3 3 1 SET domain WW_1 PF18507.1 AAS52557.2 - 1.6e-18 66.1 0.7 3.3e-18 65.1 0.7 1.6 1 0 0 1 1 1 1 WW domain AWS PF17907.1 AAS52557.2 - 4.1e-16 58.7 12.3 4.1e-16 58.7 12.3 3.1 3 0 0 3 3 3 1 AWS domain RR_TM4-6 PF06459.12 AAS52557.2 - 0.42 10.4 11.8 1.1 9.0 11.8 1.7 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LMBR1 PF04791.16 AAS52557.2 - 6.9 5.4 7.3 9.6 5.0 7.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Longin_2 PF18639.1 AAS52558.2 - 2.5e-54 183.6 0.0 4.2e-54 182.8 0.0 1.4 1 0 0 1 1 1 1 Yeast longin domain Zip PF02535.22 AAS52559.2 - 3.2e-20 72.6 7.6 8.3e-20 71.3 7.6 1.6 1 1 0 1 1 1 1 ZIP Zinc transporter MFS_1 PF07690.16 AAS52559.2 - 0.075 11.9 13.3 0.093 11.6 3.4 2.1 2 0 0 2 2 2 0 Major Facilitator Superfamily DUF3937 PF13073.6 AAS52559.2 - 0.18 11.9 0.7 0.42 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) AA_permease PF00324.21 AAS52560.1 - 2.7e-49 168.1 36.4 3.7e-49 167.6 36.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS52560.1 - 1.9e-30 106.1 34.7 2.3e-30 105.8 34.7 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3789 PF12664.7 AAS52560.1 - 0.019 14.7 1.0 0.067 12.9 1.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3789) GTP_EFTU PF00009.27 AAS52561.1 - 2.1e-36 125.3 0.0 3.2e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AAS52561.1 - 2.5e-17 62.7 0.0 6.6e-17 61.3 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 AAS52561.1 - 1.1e-13 51.0 0.0 2.1e-13 50.1 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFTUD2 PF16004.5 AAS52561.1 - 4.9e-07 30.4 2.3 0.005 17.4 0.0 2.4 1 1 1 2 2 2 2 116 kDa U5 small nuclear ribonucleoprotein component N-terminus MMR_HSR1 PF01926.23 AAS52561.1 - 7.3e-06 26.1 0.0 1.7e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 AAS52561.1 - 2.3e-05 24.7 0.0 5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AAS52561.1 - 0.00029 20.9 0.0 0.00059 19.9 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II Dynamin_N PF00350.23 AAS52561.1 - 0.011 15.8 0.0 1.3 9.1 0.0 2.3 2 0 0 2 2 2 0 Dynamin family SRPRB PF09439.10 AAS52561.1 - 0.057 12.8 0.0 1.3 8.4 0.0 2.3 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Ebp2 PF05890.12 AAS52562.2 - 9.3e-86 287.7 22.8 9.3e-86 287.7 22.8 2.5 2 1 1 3 3 3 1 Eukaryotic rRNA processing protein EBP2 polyprenyl_synt PF00348.17 AAS52563.1 - 1.2e-93 312.9 0.0 1.4e-93 312.7 0.0 1.0 1 0 0 1 1 1 1 Polyprenyl synthetase UcrQ PF02939.16 AAS52564.1 - 6.9e-34 115.6 1.3 7.9e-34 115.4 1.3 1.0 1 0 0 1 1 1 1 UcrQ family Cyt_b-c1_8 PF10890.8 AAS52564.1 - 0.0026 18.1 0.1 0.0034 17.7 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b-c1 complex subunit 8 Pkinase PF00069.25 AAS52565.1 - 5.2e-35 121.1 0.0 3.2e-23 82.4 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52565.1 - 1.2e-20 73.9 0.0 2.9e-16 59.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 AAS52565.1 - 0.0011 18.4 0.0 0.069 12.5 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 AAS52565.1 - 0.007 15.7 0.1 0.015 14.7 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Ribosomal_L14 PF00238.19 AAS52566.1 - 4.3e-42 143.1 2.2 4.9e-42 142.9 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e DUF5641 PF18701.1 AAS52566.1 - 0.16 12.2 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5641) Pkinase PF00069.25 AAS52567.1 - 1.7e-44 152.1 0.0 8.4e-44 149.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52567.1 - 9e-18 64.5 0.0 2.9e-17 62.8 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52567.1 - 0.0015 17.9 0.0 0.0038 16.6 0.0 1.6 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 AAS52567.1 - 0.029 13.7 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 AAS52567.1 - 0.031 13.9 0.0 0.068 12.7 0.0 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase LrgB PF04172.16 AAS52568.2 - 1.1e-46 159.0 7.3 1.1e-46 159.0 7.3 2.6 3 0 0 3 3 3 2 LrgB-like family LrgA PF03788.14 AAS52568.2 - 0.0029 17.5 4.7 0.0029 17.5 4.7 2.9 4 0 0 4 4 4 1 LrgA family SecE PF00584.20 AAS52568.2 - 0.47 10.4 0.0 0.47 10.4 0.0 3.4 5 0 0 5 5 5 0 SecE/Sec61-gamma subunits of protein translocation complex L51_S25_CI-B8 PF05047.16 AAS52569.1 - 2.4e-13 49.8 0.0 3.8e-13 49.1 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Pkinase PF00069.25 AAS52570.2 - 4.5e-73 245.9 0.0 5.6e-73 245.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52570.2 - 2.9e-40 138.2 0.0 4.1e-40 137.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52570.2 - 6.4e-06 25.7 0.0 1.3e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 AAS52570.2 - 0.057 12.4 0.1 0.083 11.8 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain Seadorna_VP7 PF07387.11 AAS52570.2 - 0.08 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Kdo PF06293.14 AAS52570.2 - 0.12 11.7 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS52570.2 - 0.16 11.8 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family MFS_1 PF07690.16 AAS52571.1 - 1.5e-20 73.5 27.1 1.5e-20 73.5 27.1 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily GPI2 PF06432.11 AAS52571.1 - 0.66 9.4 6.0 0.8 9.1 1.5 2.8 2 1 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase PigN PF04987.14 AAS52572.2 - 6.7e-134 447.2 45.0 9.3e-134 446.7 45.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) Sulfatase PF00884.23 AAS52572.2 - 1.8e-11 44.0 0.2 3e-11 43.3 0.2 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 AAS52572.2 - 8.5e-11 42.0 2.0 5.7e-09 36.0 1.8 2.2 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AAS52572.2 - 3.8e-05 23.2 0.0 6.5e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily DnaJ PF00226.31 AAS52573.1 - 8.7e-19 67.4 0.3 1.8e-18 66.4 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain Fez1 PF06818.15 AAS52573.1 - 0.21 12.0 2.7 4 7.8 0.0 2.7 3 0 0 3 3 3 0 Fez1 BAR_3 PF16746.5 AAS52573.1 - 0.37 10.4 4.0 0.1 12.3 0.9 1.6 2 0 0 2 2 2 0 BAR domain of APPL family Ribosomal_60s PF00428.19 AAS52573.1 - 8.1 7.1 7.2 0.73 10.5 0.5 2.6 3 0 0 3 3 3 0 60s Acidic ribosomal protein PIR PF00399.19 AAS52574.1 - 5.4e-70 229.7 112.2 2.8e-08 33.1 5.3 9.4 9 0 0 9 9 9 9 Yeast PIR protein repeat UPF0444 PF15475.6 AAS52574.1 - 0.0016 18.6 14.1 0.34 11.2 2.6 3.8 1 1 1 2 2 2 2 Transmembrane protein C12orf23, UPF0444 YdaS_antitoxin PF15943.5 AAS52574.1 - 0.053 13.4 5.7 21 5.1 0.2 3.8 1 1 2 3 3 3 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT Phage_holin_6_1 PF09682.10 AAS52574.1 - 0.27 11.7 10.3 18 5.8 0.2 4.4 1 1 4 5 5 5 0 Bacteriophage holin of superfamily 6 (Holin_LLH) PIR PF00399.19 AAS52575.1 - 0.013 15.1 15.5 0.013 15.1 5.2 2.6 2 0 0 2 2 2 0 Yeast PIR protein repeat NAP PF00956.18 AAS52576.2 - 3.4e-85 285.5 0.0 5e-85 284.9 0.0 1.2 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) BUD22 PF09073.10 AAS52576.2 - 2.6 7.3 14.4 4 6.7 9.3 2.3 2 1 0 2 2 2 0 BUD22 PET10 PF17316.2 AAS52577.1 - 5.6e-82 275.0 0.0 6.7e-82 274.8 0.0 1.0 1 0 0 1 1 1 1 Petite colonies protein 10 Hph PF13694.6 AAS52577.1 - 0.056 13.7 0.0 0.09 13.1 0.0 1.3 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family HCMVantigenic_N PF12154.8 AAS52577.1 - 0.11 12.7 0.9 0.32 11.1 0.1 2.2 2 0 0 2 2 2 0 Glycoprotein B N-terminal antigenic domain of HCMV Vps35 PF03635.17 AAS52578.1 - 7.7e-278 923.9 12.0 8.9e-278 923.7 12.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 IL34 PF15036.6 AAS52578.1 - 0.053 13.6 2.5 0.4 10.7 0.2 3.1 3 0 0 3 3 3 0 Interleukin 34 6PF2K PF01591.18 AAS52579.2 - 3.3e-87 291.4 0.0 5e-87 290.9 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 AAS52579.2 - 1.3e-36 126.2 0.0 1.9e-36 125.6 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 AAS52579.2 - 8.2e-05 22.8 0.0 0.00028 21.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain Peptidase_S64 PF08192.11 AAS52580.1 - 3.9e-248 825.5 0.0 4.8e-248 825.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S64 BORCS6 PF10157.9 AAS52580.1 - 0.12 12.6 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 zf-C3HC4 PF00097.25 AAS52581.2 - 0.0033 17.2 3.9 0.0076 16.1 3.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS52581.2 - 0.0043 17.3 2.7 0.012 15.9 2.7 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 AAS52581.2 - 0.086 12.6 1.8 0.2 11.4 1.8 1.7 1 0 0 1 1 1 0 RING-like zinc finger Fcf1 PF04900.12 AAS52583.1 - 3.1e-34 117.3 0.2 5.4e-34 116.5 0.2 1.4 1 0 0 1 1 1 1 Fcf1 PIN_9 PF18477.1 AAS52583.1 - 2.8e-13 50.2 0.2 5.1e-13 49.4 0.0 1.4 2 0 0 2 2 2 1 PIN like domain Imm-NTF2 PF15655.6 AAS52583.1 - 0.037 14.3 0.0 0.09 13.1 0.0 1.6 2 0 0 2 2 2 0 NTF2 fold immunity protein DUF4112 PF13430.6 AAS52584.1 - 1.7e-31 108.6 1.7 2.2e-31 108.3 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4112) ING PF12998.7 AAS52585.1 - 4.2e-20 72.2 5.1 8.2e-20 71.3 5.1 1.5 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding PHD PF00628.29 AAS52585.1 - 8.3e-07 28.8 8.6 1.8e-06 27.8 8.6 1.6 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 AAS52585.1 - 0.0025 18.0 1.3 0.0025 18.0 1.3 1.8 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-C4_Topoisom PF01396.19 AAS52585.1 - 1.7 8.5 7.3 9 6.2 0.5 2.6 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger MatE PF01554.18 AAS52586.2 - 4.9e-66 221.3 23.0 4.6e-39 133.6 7.7 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 AAS52586.2 - 0.0044 17.1 13.0 0.0044 17.1 13.0 4.1 3 1 1 4 4 4 1 Polysaccharide biosynthesis C-terminal domain DUF21 PF01595.20 AAS52586.2 - 8.1 6.1 7.1 1.8 8.2 1.3 2.6 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain Abhydrolase_1 PF00561.20 AAS52587.2 - 1.1e-37 130.1 0.0 3.8e-37 128.3 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AAS52587.2 - 0.034 13.4 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S37 PF05576.11 AAS52587.2 - 0.2 10.3 0.0 0.29 9.7 0.0 1.1 1 0 0 1 1 1 0 PS-10 peptidase S37 Ribosomal_S15 PF00312.22 AAS52588.1 - 6.3e-29 100.0 1.4 9.7e-29 99.4 0.3 1.9 2 0 0 2 2 2 1 Ribosomal protein S15 Gar1 PF04410.14 AAS52589.1 - 5.6e-40 136.6 0.0 6.8e-40 136.4 0.0 1.0 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region MMR_HSR1 PF01926.23 AAS52590.1 - 3.3e-14 52.9 0.0 6e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS52590.1 - 5.3e-07 29.7 0.0 9.5e-06 25.6 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase FeoB_N PF02421.18 AAS52590.1 - 1.5e-06 27.8 0.0 3.2e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AAS52590.1 - 7.3e-06 26.1 0.0 0.12 12.5 0.0 2.4 1 1 1 2 2 2 2 Dynamin family SRPRB PF09439.10 AAS52590.1 - 3.3e-05 23.4 0.0 4.9e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AAS52590.1 - 8.1e-05 22.2 0.0 0.002 17.7 0.0 2.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Septin PF00735.18 AAS52590.1 - 0.011 15.1 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Septin Arf PF00025.21 AAS52590.1 - 0.028 13.9 0.0 0.061 12.8 0.0 1.6 1 0 0 1 1 1 0 ADP-ribosylation factor family AIG1 PF04548.16 AAS52590.1 - 0.038 13.3 0.0 0.07 12.4 0.0 1.5 1 0 0 1 1 1 0 AIG1 family ABC_tran PF00005.27 AAS52590.1 - 0.043 14.3 0.1 0.11 13.0 0.0 1.7 2 0 0 2 2 1 0 ABC transporter IIGP PF05049.13 AAS52590.1 - 0.046 12.8 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) G-alpha PF00503.20 AAS52590.1 - 0.05 12.7 0.0 0.084 12.0 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit Ploopntkinase3 PF18751.1 AAS52590.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_29 PF13555.6 AAS52590.1 - 0.099 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 AAS52590.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase IBN_N PF03810.19 AAS52591.1 - 0.0059 16.5 0.1 0.12 12.3 0.0 3.0 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AAS52591.1 - 0.021 14.9 1.0 11 6.1 0.1 3.1 2 0 0 2 2 2 0 Exportin 1-like protein Brix PF04427.18 AAS52592.1 - 6.8e-27 94.8 0.4 1.2e-26 94.1 0.4 1.3 1 0 0 1 1 1 1 Brix domain RhoGEF PF00621.20 AAS52593.1 - 2e-12 47.7 0.8 3.8e-12 46.8 0.2 1.8 2 0 0 2 2 2 1 RhoGEF domain Inv-AAD PF18785.1 AAS52594.2 - 3.8e-40 136.7 0.2 7e-40 135.9 0.2 1.5 1 0 0 1 1 1 1 Invertebrate-AID/APOBEC-deaminase PseudoU_synth_2 PF00849.22 AAS52594.2 - 3.2e-31 108.6 0.0 6.7e-31 107.5 0.0 1.6 1 0 0 1 1 1 1 RNA pseudouridylate synthase dCMP_cyt_deam_1 PF00383.23 AAS52594.2 - 2e-18 66.1 0.3 4.2e-18 65.1 0.1 1.6 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AAS52594.2 - 6.9e-07 29.1 0.0 1.3e-06 28.3 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase IF2_N PF04760.15 AAS52594.2 - 0.1 12.4 0.0 0.43 10.4 0.1 2.0 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region Exo_endo_phos PF03372.23 AAS52595.2 - 0.00018 21.1 0.0 0.00078 19.0 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Git3 PF11710.8 AAS52596.2 - 2.3e-83 279.0 7.3 3.9e-83 278.2 7.3 1.4 1 0 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 GPR_Gpa2_C PF11970.8 AAS52596.2 - 2.6e-34 117.1 4.1 2.6e-34 117.1 4.1 2.2 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term MscS_TM PF12794.7 AAS52596.2 - 0.0068 15.3 1.8 0.012 14.5 1.8 1.4 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 PNTB PF02233.16 AAS52596.2 - 2.3 7.0 4.7 3.4 6.5 4.7 1.2 1 0 0 1 1 1 0 NAD(P) transhydrogenase beta subunit DUF2569 PF10754.9 AAS52596.2 - 3.4 8.1 8.6 0.96 9.9 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Inositol_P PF00459.25 AAS52597.1 - 3e-51 174.5 0.5 1.4e-50 172.4 0.5 1.8 1 1 0 1 1 1 1 Inositol monophosphatase family tRNA_Me_trans PF03054.16 AAS52598.2 - 8.6e-116 386.6 0.0 9.8e-116 386.4 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 AAS52598.2 - 0.009 15.2 0.0 0.17 11.0 0.0 2.1 2 0 0 2 2 2 1 NAD synthase CXCR4_N PF12109.8 AAS52598.2 - 0.032 14.4 0.1 0.09 13.0 0.0 1.8 2 0 0 2 2 2 0 CXCR4 Chemokine receptor N terminal Asn_synthase PF00733.21 AAS52598.2 - 0.063 12.9 0.0 0.15 11.7 0.0 1.6 2 0 0 2 2 2 0 Asparagine synthase DEAD PF00270.29 AAS52599.1 - 8.6e-49 165.7 0.0 5.3e-47 159.8 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52599.1 - 1.8e-23 83.0 0.9 3.7e-21 75.6 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DBP10CT PF08147.12 AAS52599.1 - 4.1e-19 68.6 4.9 4.1e-19 68.6 4.9 2.9 3 0 0 3 3 3 1 DBP10CT (NUC160) domain AP2 PF00847.20 AAS52599.1 - 0.068 13.4 0.5 0.25 11.6 0.5 1.9 1 0 0 1 1 1 0 AP2 domain DUF3449 PF11931.8 AAS52600.2 - 1.1e-64 217.7 0.0 3.1e-64 216.2 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) PRP9_N PF16958.5 AAS52600.2 - 2.2e-50 170.6 9.9 3.8e-50 169.8 9.9 1.4 1 0 0 1 1 1 1 Pre-mRNA-splicing factor PRP9 N-terminus SF3A3 PF16837.5 AAS52600.2 - 3.4e-15 56.3 4.4 6e-15 55.5 0.2 3.1 3 1 0 3 3 3 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 AAS52600.2 - 0.0046 17.2 3.0 0.013 15.8 0.1 2.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 AAS52600.2 - 0.0066 16.8 0.1 0.93 9.9 0.0 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) DUF2063 PF09836.9 AAS52600.2 - 0.083 13.1 0.1 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Putative DNA-binding domain zf-C2H2_3rep PF18868.1 AAS52600.2 - 0.12 13.1 0.0 15 6.3 0.0 2.6 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats CTP_transf_1 PF01148.20 AAS52601.1 - 3.1e-79 266.5 18.7 4.3e-79 266.0 18.7 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Pkinase PF00069.25 AAS52602.1 - 2.7e-60 204.0 0.0 9.3e-60 202.2 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52602.1 - 7.5e-32 110.6 0.0 2.4e-31 109.0 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52602.1 - 0.00056 19.3 0.0 0.024 14.0 0.0 2.2 2 0 0 2 2 2 1 Kinase-like Pkinase_C PF00433.24 AAS52602.1 - 0.00062 20.4 0.1 0.002 18.8 0.1 2.0 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 AAS52602.1 - 0.15 12.0 0.0 0.48 10.3 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Mannosyl_trans3 PF11051.8 AAS52603.1 - 2e-64 217.6 0.0 2.7e-64 217.2 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative ADH_zinc_N PF00107.26 AAS52604.2 - 7.6e-09 35.6 0.0 1.5e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase DUF4974 PF16344.5 AAS52604.2 - 0.09 12.8 0.1 0.23 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4974) HLH PF00010.26 AAS52605.1 - 3.3e-05 23.8 0.2 5.5e-05 23.0 0.2 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain PLC-beta_C PF08703.10 AAS52605.1 - 0.0027 17.7 0.8 0.0035 17.4 0.8 1.1 1 0 0 1 1 1 1 PLC-beta C terminal SWIRM PF04433.17 AAS52605.1 - 0.032 14.6 1.3 0.067 13.5 1.1 1.6 1 1 0 1 1 1 0 SWIRM domain DUF1751 PF08551.10 AAS52606.1 - 3.2e-29 101.4 2.5 3.2e-29 101.4 2.5 2.0 2 0 0 2 2 2 1 Eukaryotic integral membrane protein (DUF1751) Ribosomal_L27A PF00828.19 AAS52607.1 - 1.8e-31 109.5 1.6 3.9e-31 108.4 0.6 1.9 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A zf-C2H2 PF00096.26 AAS52608.1 - 1.8e-08 34.4 9.1 0.00053 20.3 3.0 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS52608.1 - 0.00038 20.8 0.3 0.00038 20.8 0.3 3.9 4 0 0 4 4 4 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS52608.1 - 0.0024 18.6 15.1 0.005 17.6 2.3 3.4 3 0 0 3 3 3 2 C2H2-type zinc finger FOXP-CC PF16159.5 AAS52608.1 - 0.0058 17.2 0.1 0.0058 17.2 0.1 3.2 3 0 0 3 3 3 1 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 AAS52608.1 - 0.15 12.4 2.1 0.6 10.5 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 AAS52608.1 - 0.18 11.6 3.0 3.2 7.6 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_2 PF12756.7 AAS52608.1 - 0.21 11.9 0.1 0.21 11.9 0.1 3.0 3 1 1 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 AAS52608.1 - 2.5 8.4 8.2 0.21 11.9 2.5 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Phos_pyr_kin PF08543.12 AAS52609.1 - 2e-09 37.2 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 AAS52609.1 - 0.00067 19.1 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase CDC27 PF09507.10 AAS52610.1 - 0.00039 19.9 0.4 0.00039 19.9 0.4 2.9 2 1 0 2 2 2 1 DNA polymerase subunit Cdc27 DUF3213 PF11491.8 AAS52610.1 - 0.058 13.6 1.0 0.76 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3213) Phage_Gp23 PF10669.9 AAS52610.1 - 0.096 13.0 5.5 0.16 12.3 5.5 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) ATP-synt_C PF00137.21 AAS52611.1 - 6.4e-34 116.1 30.1 1.7e-21 76.3 12.6 2.2 2 0 0 2 2 2 2 ATP synthase subunit C DUF2970 PF11174.8 AAS52611.1 - 2 8.4 9.3 0.77 9.7 1.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2970) Nucleopor_Nup85 PF07575.13 AAS52612.2 - 3.5e-186 620.1 11.4 4e-186 619.9 11.4 1.0 1 0 0 1 1 1 1 Nup85 Nucleoporin Urb2 PF10441.9 AAS52613.1 - 4.5e-56 190.0 1.8 1.5e-55 188.3 1.8 2.0 1 0 0 1 1 1 1 Urb2/Npa2 family PPP5 PF08321.12 AAS52613.1 - 0.0055 17.0 0.9 3.5 8.0 0.0 3.8 2 1 0 3 3 3 1 PPP5 TPR repeat region Ribosomal_S10 PF00338.22 AAS52613.1 - 0.055 13.7 0.0 17 5.7 0.1 3.0 2 0 0 2 2 2 0 Ribosomal protein S10p/S20e Telomere_reg-2 PF10193.9 AAS52613.1 - 0.2 12.1 2.3 34 4.9 0.1 4.0 4 0 0 4 4 4 0 Telomere length regulation protein Voltage_CLC PF00654.20 AAS52614.2 - 8.5e-81 271.9 24.1 8.5e-81 271.9 24.1 1.5 2 0 0 2 2 2 1 Voltage gated chloride channel CBS PF00571.28 AAS52614.2 - 6.9e-14 52.0 0.0 1.6e-07 31.6 0.0 2.5 2 0 0 2 2 2 2 CBS domain Ribosomal_L7Ae PF01248.26 AAS52615.1 - 6.3e-28 96.4 0.0 7.5e-28 96.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 AAS52615.1 - 0.00099 18.9 0.0 0.0014 18.5 0.0 1.3 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AAS52615.1 - 0.0081 16.2 0.0 0.0086 16.1 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 Pico_P2B PF01552.17 AAS52615.1 - 0.03 14.5 0.0 0.065 13.4 0.0 1.5 1 1 1 2 2 2 0 Picornavirus 2B protein HECT PF00632.25 AAS52617.1 - 4.5e-83 279.3 0.2 1.3e-81 274.4 0.0 2.5 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) OrfB_Zn_ribbon PF07282.11 AAS52617.1 - 1.5 8.8 4.3 5.3 7.0 4.3 1.9 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Rieske PF00355.26 AAS52618.1 - 4.6e-11 42.5 0.0 8.1e-11 41.7 0.0 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 AAS52618.1 - 7.5e-11 42.4 0.5 7.5e-11 42.4 0.5 1.7 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region Transp_cyt_pur PF02133.15 AAS52618.1 - 0.078 11.7 0.1 0.099 11.4 0.1 1.1 1 0 0 1 1 1 0 Permease for cytosine/purines, uracil, thiamine, allantoin DUF2235 PF09994.9 AAS52619.2 - 5.2e-79 265.6 0.0 7.5e-79 265.1 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized alpha/beta hydrolase domain (DUF2235) SNF2_N PF00176.23 AAS52620.2 - 3e-71 240.0 0.0 4.8e-71 239.3 0.0 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS52620.2 - 6.2e-21 74.8 0.0 2.1e-20 73.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52620.2 - 1.5e-07 31.6 0.2 6.5e-07 29.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_11 PF13086.6 AAS52620.2 - 0.099 12.4 3.7 1.1 8.9 0.0 3.0 3 0 0 3 3 3 0 AAA domain DUF16 PF01519.16 AAS52620.2 - 2.6 8.6 10.4 27 5.3 5.1 2.7 2 0 0 2 2 2 0 Protein of unknown function DUF16 PSK_trans_fac PF07704.11 AAS52620.2 - 9.8 7.0 7.1 3.1 8.6 1.3 3.0 2 1 0 2 2 2 0 Rv0623-like transcription factor Pet191_N PF10203.9 AAS52621.1 - 1.1e-23 83.3 5.7 1.4e-23 82.9 5.7 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein PET191 Rav1p_C PF12234.8 AAS52622.2 - 4.8e-235 781.8 6.0 1.8e-233 776.6 4.5 2.7 2 1 1 3 3 3 3 RAVE protein 1 C terminal HPS3_N PF14761.6 AAS52622.2 - 0.012 15.1 0.0 0.052 13.1 0.0 2.1 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3 Pro_isomerase PF00160.21 AAS52623.1 - 2.6e-45 154.5 0.0 3.7e-45 154.0 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TPR_1 PF00515.28 AAS52623.1 - 1e-08 34.6 8.2 2.4e-06 27.1 3.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 AAS52623.1 - 2.5e-06 27.2 7.1 0.0016 18.4 2.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS52623.1 - 6.5e-05 23.5 0.0 0.00012 22.6 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS52623.1 - 0.00037 20.5 7.7 0.013 15.7 1.4 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS52623.1 - 0.0066 16.7 2.3 0.03 14.6 0.8 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS52623.1 - 0.036 14.6 0.0 0.18 12.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 AAS52623.1 - 0.068 13.8 0.4 0.81 10.5 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF357 PF04010.13 AAS52623.1 - 0.083 13.0 1.1 0.25 11.4 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF357) TPR_10 PF13374.6 AAS52623.1 - 0.083 12.8 1.5 0.32 10.9 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat L27_N PF09060.10 AAS52623.1 - 0.15 12.1 0.2 0.46 10.6 0.2 1.8 2 0 0 2 2 1 0 L27_N MIT PF04212.18 AAS52623.1 - 0.34 11.0 3.3 1.2 9.3 0.3 2.7 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 AAS52623.1 - 2.5 8.4 6.0 4.1 7.7 1.5 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Sec7 PF01369.20 AAS52624.2 - 5.7e-68 228.2 1.6 1.3e-67 227.0 1.6 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 AAS52624.2 - 1.5e-17 63.9 11.7 6.3e-17 61.9 2.4 3.8 3 1 0 3 3 3 2 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 AAS52624.2 - 0.0005 19.8 2.7 0.0005 19.8 2.7 3.3 4 0 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 STI1 PF17830.1 AAS52624.2 - 0.011 15.7 1.6 15 5.7 0.0 4.0 4 0 0 4 4 4 0 STI1 domain Mito_carr PF00153.27 AAS52625.1 - 1.7e-13 50.3 1.4 8.4e-09 35.2 0.1 2.8 2 1 0 2 2 2 2 Mitochondrial carrier protein YfbU PF03887.14 AAS52625.1 - 0.14 12.2 0.1 0.67 10.0 0.1 2.0 1 1 1 2 2 2 0 YfbU domain OMPdecase PF00215.24 AAS52626.1 - 1.7e-75 253.5 0.0 2e-75 253.2 0.0 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family zf-Tim10_DDP PF02953.15 AAS52627.1 - 1.5e-21 75.8 6.6 2.2e-21 75.2 6.6 1.3 1 0 0 1 1 1 1 Tim10/DDP family zinc finger Tam41_Mmp37 PF09139.11 AAS52627.1 - 0.086 12.3 0.5 0.096 12.1 0.5 1.0 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial MFS_1 PF07690.16 AAS52628.1 - 1.6e-25 89.8 27.9 2.5e-22 79.3 9.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS52628.1 - 3.6e-13 49.2 1.2 3.6e-13 49.2 1.2 1.7 2 0 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 AAS52628.1 - 0.00034 19.2 0.3 0.00059 18.4 0.3 1.3 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF4064 PF13273.6 AAS52628.1 - 0.97 9.7 3.7 0.62 10.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Mak16 PF04874.14 AAS52629.1 - 1.6 9.4 12.5 0.14 12.7 6.5 2.4 2 0 0 2 2 2 0 Mak16 protein C-terminal region TPP_enzyme_N PF02776.18 AAS52630.1 - 4.3e-38 130.6 0.0 1.7e-37 128.6 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AAS52630.1 - 1.7e-25 89.4 0.0 2.7e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AAS52630.1 - 7.8e-20 71.2 0.1 2.4e-19 69.6 0.0 1.9 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain tRNA-synt_2 PF00152.20 AAS52631.1 - 1.3e-71 241.3 0.0 1.6e-71 241.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS52631.1 - 0.00056 19.8 0.0 0.0013 18.6 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AAS52631.1 - 0.033 13.7 0.0 5.3 6.4 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.25 AAS52631.1 - 0.19 11.7 0.0 2.9 7.8 0.0 2.5 3 0 0 3 3 3 0 tRNA synthetase class II core domain (G, H, P, S and T) zf-Nse PF11789.8 AAS52632.1 - 7e-20 70.6 0.2 2.6e-19 68.8 0.5 1.8 2 0 0 2 2 2 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 AAS52632.1 - 4.5e-05 23.4 4.1 0.00015 21.8 1.2 2.4 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 AAS52632.1 - 0.0026 17.6 2.0 0.0036 17.1 1.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Rtf2 PF04641.12 AAS52632.1 - 0.0033 16.8 0.5 0.0052 16.2 0.1 1.5 2 0 0 2 2 2 1 Rtf2 RING-finger zf-RING_2 PF13639.6 AAS52632.1 - 0.004 17.5 1.6 0.0069 16.7 1.2 1.7 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AAS52632.1 - 0.043 13.7 0.3 0.043 13.7 0.3 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-MIZ PF02891.20 AAS52632.1 - 0.077 12.8 2.3 0.13 12.1 1.9 1.6 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger Zn_ribbon_17 PF17120.5 AAS52632.1 - 0.094 12.3 0.2 0.16 11.6 0.2 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-rbx1 PF12678.7 AAS52632.1 - 0.54 10.6 0.1 0.54 10.6 0.1 2.3 2 1 1 3 3 3 0 RING-H2 zinc finger domain TACC_C PF05010.14 AAS52633.1 - 0.00032 20.6 0.3 0.043 13.6 0.3 2.2 2 0 0 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TetR_C_19 PF17924.1 AAS52633.1 - 0.24 12.0 2.4 0.29 11.7 0.4 2.1 2 2 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FAM177 PF14774.6 AAS52634.1 - 0.046 14.1 0.3 0.095 13.1 0.3 1.4 1 0 0 1 1 1 0 FAM177 family Phosphodiest PF01663.22 AAS52635.1 - 1.7e-85 287.8 0.8 2.2e-85 287.4 0.8 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase YjeF_N PF03853.15 AAS52636.2 - 2.9e-32 111.9 0.3 4.5e-32 111.3 0.3 1.3 1 0 0 1 1 1 1 YjeF-related protein N-terminus FDF PF09532.10 AAS52636.2 - 2.4e-09 38.0 4.8 5.6e-09 36.8 4.8 1.5 1 0 0 1 1 1 1 FDF domain LSM PF01423.22 AAS52636.2 - 0.12 12.1 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 LSM domain Arm PF00514.23 AAS52637.1 - 1e-70 231.8 31.2 1.4e-11 44.0 0.0 11.2 11 0 0 11 11 11 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 AAS52637.1 - 1.3e-21 76.6 12.8 0.00034 21.0 0.0 7.5 5 1 2 7 7 7 6 HEAT-like repeat HEAT_2 PF13646.6 AAS52637.1 - 3.9e-17 62.4 5.2 0.0072 16.7 0.0 6.6 3 2 2 6 6 6 4 HEAT repeats HEAT PF02985.22 AAS52637.1 - 2.9e-14 51.9 15.0 0.069 13.5 0.1 9.0 8 0 0 8 8 8 5 HEAT repeat Adaptin_N PF01602.20 AAS52637.1 - 3.7e-12 45.6 11.3 9e-09 34.4 3.0 2.4 1 1 1 2 2 2 2 Adaptin N terminal region Arm_2 PF04826.13 AAS52637.1 - 6.9e-11 42.1 8.3 2.4e-08 33.8 1.6 2.6 2 1 0 2 2 2 2 Armadillo-like KAP PF05804.12 AAS52637.1 - 2.6e-09 35.8 1.9 1.5e-08 33.3 1.5 2.1 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) V-ATPase_H_C PF11698.8 AAS52637.1 - 2.6e-06 27.5 3.5 0.016 15.3 0.1 5.0 3 2 3 6 6 6 1 V-ATPase subunit H Cnd1 PF12717.7 AAS52637.1 - 1e-05 25.6 10.9 0.054 13.5 0.3 5.2 1 1 2 5 5 5 4 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_N PF03224.14 AAS52637.1 - 2e-05 24.0 5.8 0.0058 16.0 0.3 3.7 1 1 3 4 4 4 3 V-ATPase subunit H DUF3361 PF11841.8 AAS52637.1 - 3e-05 24.0 9.5 0.0049 16.8 0.4 4.5 2 2 2 4 4 4 1 Domain of unknown function (DUF3361) Tti2 PF10521.9 AAS52637.1 - 0.00016 21.3 0.0 0.12 11.9 0.0 3.3 3 0 0 3 3 3 1 Tti2 family Vac14_Fab1_bd PF12755.7 AAS52637.1 - 0.00055 20.5 0.7 1.1 9.9 0.0 3.6 3 1 0 4 4 2 2 Vacuolar 14 Fab1-binding region LSM PF01423.22 AAS52638.1 - 1.4e-07 31.0 0.0 1.9e-07 30.6 0.0 1.2 1 0 0 1 1 1 1 LSM domain UQ_con PF00179.26 AAS52640.1 - 1.8e-40 137.8 0.1 2.5e-40 137.4 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme SDA1 PF05285.12 AAS52640.1 - 5.6 6.3 9.5 7.4 5.9 9.5 1.1 1 0 0 1 1 1 0 SDA1 Alpha-amylase_C PF02806.18 AAS52641.1 - 7.6e-27 93.6 0.1 1.9e-26 92.3 0.1 1.7 1 0 0 1 1 1 1 Alpha amylase, C-terminal all-beta domain CBM_48 PF02922.18 AAS52641.1 - 1.3e-15 57.5 0.0 3.9e-15 56.0 0.0 1.9 1 0 0 1 1 1 1 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase PF00128.24 AAS52641.1 - 3.3e-15 56.5 0.3 3.9e-14 53.0 0.1 2.2 1 1 1 2 2 2 1 Alpha amylase, catalytic domain Frag1 PF10277.9 AAS52642.2 - 1.9e-31 109.3 9.7 1.9e-31 109.3 9.7 3.9 3 2 0 3 3 3 1 Frag1/DRAM/Sfk1 family Sugar_tr PF00083.24 AAS52643.1 - 1.7e-106 356.8 20.1 2e-106 356.6 20.1 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS52643.1 - 2.1e-22 79.6 25.1 1.3e-21 77.0 18.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2373 PF10180.9 AAS52644.2 - 5.3e-21 74.2 0.0 8.2e-21 73.6 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2373) HAD PF12710.7 AAS52645.2 - 0.0003 21.3 0.0 0.00044 20.7 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DNA_pol_B_thumb PF14791.6 AAS52646.1 - 1.9e-16 59.9 0.0 3.8e-16 59.0 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 AAS52646.1 - 3e-14 53.1 0.4 1.2e-13 51.2 0.4 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_B_palm PF14792.6 AAS52646.1 - 6.3e-12 45.7 0.0 1.7e-11 44.3 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_lambd_f PF10391.9 AAS52646.1 - 1.5e-09 37.5 0.0 3.2e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda BRCT_2 PF16589.5 AAS52646.1 - 2e-05 24.9 0.0 3.5e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 AAS52646.1 - 0.062 13.7 0.0 0.78 10.2 0.0 2.4 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain PGK PF00162.19 AAS52647.2 - 5.5e-149 496.2 0.2 6.3e-149 496.0 0.2 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase FixQ PF05545.11 AAS52647.2 - 0.25 11.4 0.9 0.57 10.2 0.9 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ TauD PF02668.16 AAS52650.2 - 1.9e-37 129.5 0.1 3e-37 128.9 0.1 1.2 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 AAS52650.2 - 2e-08 34.8 3.8 5.8e-07 30.1 1.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF971) CsiD PF08943.10 AAS52650.2 - 0.0088 15.2 0.0 0.41 9.7 0.0 2.1 2 0 0 2 2 2 2 CsiD GTP_EFTU PF00009.27 AAS52651.1 - 3.1e-31 108.4 5.1 2.3e-29 102.4 5.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 AAS52651.1 - 5.3e-23 81.2 0.1 1.5e-22 79.7 0.1 1.8 1 0 0 1 1 1 1 Translation-initiation factor 2 MMR_HSR1 PF01926.23 AAS52651.1 - 1.9e-09 37.6 0.4 7.4e-09 35.7 0.4 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase IF2_N PF04760.15 AAS52651.1 - 1.7e-07 31.0 0.3 4.6e-07 29.6 0.0 2.0 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region RsgA_GTPase PF03193.16 AAS52651.1 - 4e-05 23.6 5.8 0.00066 19.6 3.8 2.5 1 1 1 2 2 2 1 RsgA GTPase SRPRB PF09439.10 AAS52651.1 - 0.0031 17.0 0.2 0.0064 15.9 0.2 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 AAS52651.1 - 0.0049 16.5 0.1 0.0094 15.6 0.1 1.5 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 AAS52651.1 - 0.0066 16.0 2.0 0.045 13.3 2.0 2.4 1 1 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AAS52651.1 - 0.0094 16.0 0.2 3.5 7.7 0.1 2.7 1 1 1 2 2 2 1 Dynamin family DUF5462 PF17547.2 AAS52651.1 - 0.015 14.6 1.5 0.28 10.5 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5462) GTP_EFTU_D2 PF03144.25 AAS52651.1 - 0.17 12.3 3.3 2.1 8.8 0.1 3.1 3 0 0 3 3 3 0 Elongation factor Tu domain 2 PduV-EutP PF10662.9 AAS52651.1 - 0.18 11.6 1.4 0.69 9.7 1.4 1.9 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PDCD2_C PF04194.13 AAS52652.2 - 2.1e-40 138.7 0.0 2.2e-38 132.0 0.0 2.4 2 0 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain ABC_tran PF00005.27 AAS52653.1 - 7.6e-46 156.0 6.9 1e-22 81.1 0.0 3.4 4 0 0 4 4 3 2 ABC transporter ABC_tran_Xtn PF12848.7 AAS52653.1 - 2.9e-19 68.9 10.2 2.9e-19 68.9 10.2 3.4 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 AAS52653.1 - 6.3e-17 62.3 15.5 3.1e-05 23.9 0.0 5.5 4 2 0 6 6 5 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS52653.1 - 4.5e-11 42.6 0.2 0.0012 18.3 0.2 4.1 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AAS52653.1 - 4.4e-07 30.0 0.0 0.049 13.5 0.0 2.9 2 0 0 2 2 2 2 RsgA GTPase AAA_28 PF13521.6 AAS52653.1 - 7.6e-07 29.5 0.2 0.073 13.3 0.0 3.2 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.6 AAS52653.1 - 9.6e-07 29.3 1.8 0.04 14.3 0.2 3.1 3 1 0 3 3 2 2 AAA ATPase domain AAA PF00004.29 AAS52653.1 - 1.3e-06 28.8 0.2 0.12 12.8 0.0 4.4 4 1 0 4 4 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AAS52653.1 - 1.8e-06 28.3 1.2 0.14 12.5 0.1 3.7 3 2 0 3 3 3 2 AAA domain AAA_30 PF13604.6 AAS52653.1 - 2.2e-06 27.5 0.0 0.77 9.5 0.0 4.7 4 1 0 4 4 4 1 AAA domain AAA_23 PF13476.6 AAS52653.1 - 2.8e-06 28.0 24.0 0.2 12.1 0.0 5.2 5 0 0 5 5 5 2 AAA domain MMR_HSR1 PF01926.23 AAS52653.1 - 3.7e-06 27.0 0.0 0.1 12.7 0.0 3.4 3 0 0 3 3 3 2 50S ribosome-binding GTPase NACHT PF05729.12 AAS52653.1 - 9.4e-06 25.6 0.1 0.059 13.3 0.1 2.6 2 0 0 2 2 2 2 NACHT domain AAA_18 PF13238.6 AAS52653.1 - 1e-05 26.1 5.1 0.2 12.2 0.0 4.5 5 1 0 5 5 4 2 AAA domain AAA_29 PF13555.6 AAS52653.1 - 2.3e-05 24.0 3.4 0.12 12.2 0.0 2.9 3 0 0 3 3 2 2 P-loop containing region of AAA domain AAA_14 PF13173.6 AAS52653.1 - 3e-05 24.1 0.0 0.46 10.5 0.0 3.3 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.6 AAS52653.1 - 6.1e-05 23.2 0.8 0.11 12.7 0.0 3.4 3 1 0 3 3 2 1 AAA domain AAA_24 PF13479.6 AAS52653.1 - 0.00031 20.5 0.0 0.87 9.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain PduV-EutP PF10662.9 AAS52653.1 - 0.00035 20.3 0.2 0.35 10.6 0.0 2.9 3 0 0 3 3 2 1 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 AAS52653.1 - 0.00058 20.2 0.3 0.92 9.9 0.0 3.1 3 0 0 3 3 2 1 RNA helicase NB-ARC PF00931.22 AAS52653.1 - 0.00059 19.1 0.2 0.23 10.6 0.0 2.8 2 1 0 2 2 2 1 NB-ARC domain AAA_15 PF13175.6 AAS52653.1 - 0.0007 19.4 24.2 0.028 14.1 0.0 4.7 3 1 1 4 4 4 2 AAA ATPase domain Roc PF08477.13 AAS52653.1 - 0.00098 19.3 0.0 1.7 8.9 0.0 2.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ATP-synt_ab PF00006.25 AAS52653.1 - 0.001 18.8 0.0 0.31 10.7 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain MeaB PF03308.16 AAS52653.1 - 0.0013 17.8 0.0 1.4 7.8 0.0 2.6 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_7 PF12775.7 AAS52653.1 - 0.0014 18.1 0.2 0.78 9.2 0.0 2.7 3 0 0 3 3 2 1 P-loop containing dynein motor region TsaE PF02367.17 AAS52653.1 - 0.003 17.5 0.0 0.53 10.3 0.0 2.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 AAS52653.1 - 0.0034 17.4 0.1 4.3 7.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) G-alpha PF00503.20 AAS52653.1 - 0.0047 16.1 1.3 0.53 9.4 0.0 3.0 3 0 0 3 3 3 1 G-protein alpha subunit DUF815 PF05673.13 AAS52653.1 - 0.006 15.8 0.0 3.1 6.9 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_25 PF13481.6 AAS52653.1 - 0.0066 16.1 0.0 1.2 8.7 0.0 2.9 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AAS52653.1 - 0.012 14.9 0.0 3.8 6.7 0.0 2.8 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 AAS52653.1 - 0.012 15.5 0.0 1.3 8.9 0.0 3.3 3 0 0 3 3 3 0 Rad17 P-loop domain MobB PF03205.14 AAS52653.1 - 0.015 15.2 0.0 0.42 10.5 0.0 2.6 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B FeoB_N PF02421.18 AAS52653.1 - 0.019 14.5 0.0 5.8 6.4 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B Septin PF00735.18 AAS52653.1 - 0.019 14.2 1.1 4.8 6.4 0.0 3.0 3 0 0 3 3 3 0 Septin NTPase_1 PF03266.15 AAS52653.1 - 0.02 14.8 0.0 3 7.7 0.0 2.8 2 0 0 2 2 2 0 NTPase cobW PF02492.19 AAS52653.1 - 0.021 14.4 0.1 6 6.4 0.1 2.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 AAS52653.1 - 0.023 14.3 0.4 2.3 7.8 0.0 3.2 4 0 0 4 4 3 0 SRP54-type protein, GTPase domain Pox_A32 PF04665.12 AAS52653.1 - 0.028 13.9 0.7 0.68 9.3 0.0 2.9 3 0 0 3 3 3 0 Poxvirus A32 protein SbcCD_C PF13558.6 AAS52653.1 - 0.034 14.4 0.1 22 5.4 0.0 3.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.6 AAS52653.1 - 0.045 14.1 0.1 0.72 10.2 0.0 2.8 3 0 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 AAS52653.1 - 0.052 12.4 0.2 0.28 10.0 0.0 2.1 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain Ras PF00071.22 AAS52653.1 - 0.063 12.9 3.0 9.9 5.7 0.1 3.8 4 0 0 4 4 4 0 Ras family Viral_helicase1 PF01443.18 AAS52653.1 - 0.071 12.8 0.0 2.2 7.9 0.0 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_17 PF13207.6 AAS52653.1 - 0.48 10.9 5.8 15 6.0 0.0 4.3 3 1 0 4 4 4 0 AAA domain DUF2813 PF11398.8 AAS52653.1 - 0.54 9.5 5.9 1.7 7.8 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2813) ATPase_2 PF01637.18 AAS52653.1 - 0.84 9.5 0.0 0.84 9.5 0.0 3.5 4 1 0 4 4 2 0 ATPase domain predominantly from Archaea DUF87 PF01935.17 AAS52653.1 - 1.9 8.6 0.0 1.9 8.6 0.0 5.2 5 1 1 6 6 5 0 Helicase HerA, central domain Dynamin_N PF00350.23 AAS52653.1 - 2.2 8.3 11.1 0.4 10.7 0.1 3.8 3 1 1 4 4 4 0 Dynamin family Tup_N PF08581.10 AAS52653.1 - 2.4 8.5 10.8 0.13 12.6 2.8 2.6 2 0 0 2 2 2 0 Tup N-terminal DUF1043 PF06295.12 AAS52653.1 - 5.2 7.1 8.2 2.1 8.4 1.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) RNB PF00773.19 AAS52654.1 - 4.6e-100 335.1 0.0 7e-100 334.5 0.0 1.2 1 0 0 1 1 1 1 RNB domain Rrp44_CSD1 PF17216.3 AAS52654.1 - 7e-67 223.7 0.0 1.4e-66 222.7 0.0 1.6 1 0 0 1 1 1 1 Rrp44-like cold shock domain Rrp44_S1 PF17215.3 AAS52654.1 - 1.1e-29 102.2 2.0 1.1e-29 102.2 2.0 2.1 2 0 0 2 2 2 1 S1 domain OB_Dis3 PF17849.1 AAS52654.1 - 2.3e-19 69.2 0.0 5.8e-19 67.9 0.0 1.8 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) PIN_4 PF13638.6 AAS52654.1 - 3.7e-16 59.6 0.3 8.7e-16 58.4 0.3 1.7 1 0 0 1 1 1 1 PIN domain CSD2 PF17876.1 AAS52654.1 - 0.00034 20.7 0.0 0.0059 16.7 0.0 2.9 2 0 0 2 2 2 1 Cold shock domain Dis3l2_C_term PF17877.1 AAS52654.1 - 0.0047 17.2 0.4 0.015 15.6 0.4 1.8 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal AA_permease PF00324.21 AAS52655.3 - 8.7e-124 413.7 39.6 1e-123 413.5 39.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS52655.3 - 1.9e-33 116.0 41.7 2.4e-33 115.6 41.7 1.1 1 0 0 1 1 1 1 Amino acid permease UCH PF00443.29 AAS52656.2 - 9.3e-47 159.7 0.0 1.1e-46 159.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS52656.2 - 1.4e-11 44.6 0.5 4.7e-10 39.6 0.5 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 AAS52656.2 - 0.0006 19.5 0.0 0.0029 17.3 0.0 2.2 3 0 0 3 3 3 1 Ubiquitin family DUF1690 PF07956.11 AAS52657.2 - 2.4e-40 138.2 6.6 2.9e-40 137.9 6.6 1.1 1 0 0 1 1 1 1 Protein of Unknown function (DUF1690) DUF16 PF01519.16 AAS52657.2 - 0.086 13.3 2.5 0.14 12.7 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 SUR7 PF06687.12 AAS52658.2 - 1.1e-16 61.1 11.4 1.7e-16 60.5 11.4 1.1 1 0 0 1 1 1 1 SUR7/PalI family FA_desaturase PF00487.24 AAS52658.2 - 0.01 15.7 1.6 0.01 15.7 1.6 1.6 2 0 0 2 2 2 0 Fatty acid desaturase SNARE PF05739.19 AAS52659.2 - 2.9e-15 56.0 0.7 2.9e-15 56.0 0.7 2.4 2 0 0 2 2 2 1 SNARE domain DUF5069 PF16798.5 AAS52659.2 - 0.0056 16.9 0.3 0.0099 16.1 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5069) Mlp PF03304.13 AAS52659.2 - 0.0069 16.6 0.7 0.013 15.7 0.7 1.4 1 0 0 1 1 1 1 Mlp lipoprotein family TMPIT PF07851.13 AAS52659.2 - 0.042 13.1 1.6 0.061 12.6 1.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein Syntaxin PF00804.25 AAS52659.2 - 0.076 12.7 7.9 0.2 11.3 7.9 1.9 1 1 0 1 1 1 0 Syntaxin Use1 PF09753.9 AAS52659.2 - 0.15 11.8 9.5 0.47 10.1 9.5 1.7 1 1 0 1 1 1 0 Membrane fusion protein Use1 Orf78 PF06024.12 AAS52659.2 - 0.3 11.4 1.3 2.9 8.2 0.1 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DSPn PF14671.6 AAS52660.2 - 1.1e-45 155.6 0.0 2.7e-45 154.3 0.0 1.7 2 0 0 2 2 2 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 AAS52660.2 - 2.1e-23 82.6 0.0 2.4e-22 79.2 0.0 2.3 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AAS52660.2 - 0.00042 19.9 0.0 0.00087 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase CDKN3 PF05706.12 AAS52660.2 - 0.0026 17.5 0.1 0.0049 16.5 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) PTPlike_phytase PF14566.6 AAS52660.2 - 0.02 15.0 0.0 0.057 13.5 0.0 1.8 1 0 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 AAS52660.2 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Med13_C PF06333.12 AAS52660.2 - 1 8.5 5.3 1.8 7.8 5.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Lin-8 PF03353.15 AAS52660.2 - 8.1 5.9 7.1 13 5.2 7.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Acetyltransf_13 PF13880.6 AAS52661.2 - 5.4e-20 71.1 0.1 9.6e-20 70.4 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase zf-C2H2_3 PF13878.6 AAS52661.2 - 7e-11 41.8 2.4 1.2e-10 41.0 2.4 1.4 1 0 0 1 1 1 1 zinc-finger of acetyl-transferase ESCO Acetyltransf_1 PF00583.25 AAS52661.2 - 0.00029 21.0 0.0 0.00047 20.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS52661.2 - 0.00052 20.4 0.0 0.0012 19.3 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AAS52661.2 - 0.012 15.6 0.0 0.031 14.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 AAS52661.2 - 0.023 15.4 0.1 0.038 14.7 0.1 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Flo11 PF10182.9 AAS52662.2 - 2.2e-54 183.7 1.5 4.4e-54 182.7 1.5 1.5 1 0 0 1 1 1 1 Flo11 domain PHP PF02811.19 AAS52663.2 - 1.5e-13 51.4 0.0 2.5e-13 50.7 0.0 1.4 1 0 0 1 1 1 1 PHP domain ProRS-C_1 PF09180.11 AAS52664.1 - 7e-25 87.0 0.6 1.7e-24 85.8 0.6 1.7 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 AAS52664.1 - 1.3e-19 70.1 0.0 3.1e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AAS52664.1 - 1.1e-16 61.3 0.0 2.1e-16 60.4 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 AAS52664.1 - 0.0015 18.6 0.3 0.0031 17.6 0.3 1.5 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain tRNA-synt_2 PF00152.20 AAS52665.2 - 3.8e-90 302.1 0.0 6.2e-90 301.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS52665.2 - 6.5e-11 42.1 0.0 1.3e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain Ins134_P3_kin PF05770.11 AAS52665.2 - 0.022 14.3 0.0 0.048 13.2 0.0 1.5 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain RR_TM4-6 PF06459.12 AAS52665.2 - 0.069 13.0 0.3 0.5 10.1 0.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 HR1 PF02185.16 AAS52665.2 - 0.24 11.5 5.7 0.47 10.6 5.7 1.4 1 0 0 1 1 1 0 Hr1 repeat Lyase_1 PF00206.20 AAS52666.1 - 1.8e-99 333.1 0.0 2.7e-99 332.5 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 AAS52666.1 - 1.6e-22 80.0 0.1 5.5e-22 78.3 0.0 2.0 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal DUF1776 PF08643.10 AAS52667.1 - 3e-79 266.5 0.0 3.7e-79 266.2 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) adh_short PF00106.25 AAS52667.1 - 0.03 13.8 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Ysc84 PF04366.12 AAS52668.1 - 1.5e-42 144.3 0.2 2.4e-42 143.7 0.2 1.3 1 0 0 1 1 1 1 Las17-binding protein actin regulator SH3_1 PF00018.28 AAS52668.1 - 1.2e-15 56.8 0.1 2.3e-15 55.9 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS52668.1 - 5e-13 48.7 0.0 1.1e-12 47.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS52668.1 - 4.8e-11 42.2 0.0 1e-10 41.1 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain RRM_1 PF00076.22 AAS52669.2 - 1.2e-47 159.6 8.5 3.5e-17 62.0 0.5 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AAS52669.2 - 0.0001 22.3 0.4 1.5 8.9 0.1 3.8 3 0 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 AAS52669.2 - 0.00027 20.9 0.1 0.67 10.0 0.1 3.3 4 0 0 4 4 4 2 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 AAS52669.2 - 0.00093 18.8 0.0 8 6.1 0.0 3.6 2 1 1 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 AAS52669.2 - 0.022 14.8 0.3 59 3.8 0.0 3.9 3 1 0 3 3 3 0 Limkain b1 Njmu-R1 PF15053.6 AAS52669.2 - 0.064 12.4 0.6 0.12 11.5 0.6 1.3 1 0 0 1 1 1 0 Mjmu-R1-like protein family SET_assoc PF11767.8 AAS52669.2 - 0.082 12.6 0.2 39 4.0 0.1 3.6 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated RRM_7 PF16367.5 AAS52669.2 - 0.094 12.8 0.1 1.6 8.9 0.0 3.0 3 2 0 3 3 3 0 RNA recognition motif Myc_N PF01056.18 AAS52669.2 - 0.99 9.2 5.9 2.4 8.0 5.9 1.6 1 0 0 1 1 1 0 Myc amino-terminal region Nuf2 PF03800.14 AAS52670.1 - 1.4e-39 135.4 0.3 1.4e-39 135.4 0.3 2.2 2 0 0 2 2 2 1 Nuf2 family DHR10 PF18595.1 AAS52670.1 - 2.4e-05 24.4 20.7 2.4e-05 24.4 20.7 2.9 2 1 0 2 2 2 1 Designed helical repeat protein 10 domain SF3A2 PF16835.5 AAS52671.1 - 2.5e-23 82.3 0.0 4.4e-23 81.5 0.0 1.3 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) zf-met PF12874.7 AAS52671.1 - 1.5e-06 28.4 1.5 2.9e-06 27.5 1.5 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 AAS52671.1 - 0.03 14.6 0.2 0.061 13.7 0.2 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) OrsD PF12013.8 AAS52671.1 - 0.097 13.1 0.2 0.32 11.5 0.2 1.9 1 1 0 1 1 1 0 Orsellinic acid/F9775 biosynthesis cluster protein D DUF592 PF04574.13 AAS52672.1 - 7.8e-68 227.1 0.1 1.3e-67 226.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF592) SIR2 PF02146.17 AAS52672.1 - 1.9e-63 213.6 0.0 3.2e-63 212.8 0.0 1.4 1 0 0 1 1 1 1 Sir2 family TPP_enzyme_M PF00205.22 AAS52672.1 - 0.00022 20.9 0.0 0.053 13.3 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain Paired_CXXCH_1 PF09699.10 AAS52672.1 - 0.11 12.2 0.2 0.25 11.1 0.2 1.6 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) HLH PF00010.26 AAS52673.1 - 5.1e-15 55.2 0.0 7.9e-15 54.6 0.0 1.3 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Ku_C PF03730.14 AAS52673.1 - 0.16 12.7 1.7 0.76 10.5 0.4 2.1 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm AAA PF00004.29 AAS52674.1 - 1.7e-40 138.5 0.0 2.8e-40 137.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS52674.1 - 1e-10 41.3 0.2 2e-10 40.3 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 AAS52674.1 - 2.2e-09 37.1 0.0 4.2e-09 36.2 0.0 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AAS52674.1 - 7.9e-06 26.1 0.0 2e-05 24.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 AAS52674.1 - 1.5e-05 24.3 0.0 2.5e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 AAS52674.1 - 1.9e-05 24.9 0.2 0.017 15.4 0.1 2.6 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 AAS52674.1 - 7.4e-05 22.8 0.3 0.00038 20.5 0.0 2.4 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS52674.1 - 0.00013 22.4 0.1 0.0031 17.9 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AAS52674.1 - 0.0008 19.2 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AAS52674.1 - 0.0031 17.8 0.1 0.0077 16.5 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 AAS52674.1 - 0.0092 16.5 0.3 0.029 14.9 0.0 2.0 3 0 0 3 3 1 1 AAA domain AAA_14 PF13173.6 AAS52674.1 - 0.011 15.8 0.0 0.024 14.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AAS52674.1 - 0.016 15.4 0.0 0.031 14.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 AAS52674.1 - 0.017 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_3 PF07726.11 AAS52674.1 - 0.017 15.0 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 AAS52674.1 - 0.021 14.7 0.3 0.26 11.2 0.0 2.5 3 0 0 3 3 3 0 NTPase TIP49 PF06068.13 AAS52674.1 - 0.023 13.9 0.1 0.053 12.7 0.1 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain RNA_helicase PF00910.22 AAS52674.1 - 0.036 14.5 0.0 0.1 13.0 0.0 1.9 2 0 0 2 2 1 0 RNA helicase ATPase PF06745.13 AAS52674.1 - 0.036 13.4 0.1 0.49 9.7 0.1 2.3 1 1 0 2 2 2 0 KaiC Mg_chelatase PF01078.21 AAS52674.1 - 0.057 12.8 0.1 0.11 11.8 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 AAS52674.1 - 0.057 13.0 1.4 0.46 10.0 0.4 2.4 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 AAS52674.1 - 0.092 12.0 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin NACHT PF05729.12 AAS52674.1 - 0.096 12.6 0.1 0.59 10.0 0.1 2.1 1 1 1 2 2 2 0 NACHT domain AAA_24 PF13479.6 AAS52674.1 - 0.12 12.1 1.0 0.28 10.9 0.3 2.1 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AAS52674.1 - 1.9 8.0 4.0 0.5 9.9 0.1 2.0 2 1 0 2 2 2 0 P-loop containing dynein motor region PP2C PF00481.21 AAS52675.2 - 1.2e-72 244.7 0.1 1.6e-72 244.2 0.1 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Med2 PF11214.8 AAS52676.1 - 4.3e-36 123.1 2.6 9.4e-36 122.0 2.6 1.5 1 0 0 1 1 1 1 Mediator complex subunit 2 DUF3987 PF13148.6 AAS52676.1 - 0.00069 18.7 1.2 0.0012 17.9 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) Med29 PF11568.8 AAS52676.1 - 0.013 15.7 3.7 0.031 14.5 3.7 1.6 1 1 0 1 1 1 0 Mediator complex subunit 29 DUF3086 PF11285.8 AAS52676.1 - 0.099 11.7 5.1 0.15 11.1 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) CCDC53 PF10152.9 AAS52676.1 - 2.3 8.6 9.3 1.8 8.9 3.4 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex ATP-synt_DE_N PF02823.16 AAS52677.1 - 1.3e-17 63.4 0.2 1.9e-17 62.9 0.2 1.3 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Rad21_Rec8_N PF04825.13 AAS52678.2 - 2e-20 73.0 0.0 4.5e-20 71.9 0.0 1.5 1 0 0 1 1 1 1 N terminus of Rad21 / Rec8 like protein Rad21_Rec8 PF04824.16 AAS52678.2 - 1.3e-09 37.2 0.0 3.4e-09 35.9 0.0 1.8 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DRIM PF07539.12 AAS52679.2 - 5.5e-164 546.9 7.3 5.5e-164 546.9 7.3 3.9 4 2 1 5 5 5 2 Down-regulated in metastasis HEAT_2 PF13646.6 AAS52679.2 - 0.00023 21.5 0.2 0.55 10.7 0.1 5.2 4 0 0 4 4 4 1 HEAT repeats UNC45-central PF11701.8 AAS52679.2 - 0.012 15.6 15.2 8.9 6.2 0.0 8.1 7 2 1 8 8 8 0 Myosin-binding striated muscle assembly central V-ATPase_H_C PF11698.8 AAS52679.2 - 0.051 13.7 0.6 6.3 6.9 0.0 4.4 2 0 0 2 2 2 0 V-ATPase subunit H HEAT PF02985.22 AAS52679.2 - 1.2 9.6 6.4 38 4.9 0.0 5.7 6 0 0 6 6 6 0 HEAT repeat HMG_box PF00505.19 AAS52680.2 - 2.5e-16 59.9 1.9 4.7e-16 59.0 1.9 1.5 1 0 0 1 1 1 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS52680.2 - 2.3e-13 50.5 0.8 4e-13 49.7 0.8 1.4 1 0 0 1 1 1 1 HMG-box domain Stap_Strp_tox_C PF02876.17 AAS52680.2 - 0.11 12.8 0.8 0.21 11.9 0.8 1.4 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, beta-grasp domain DUF155 PF02582.14 AAS52681.1 - 1e-56 191.8 1.4 1.6e-56 191.1 1.4 1.3 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 UPF0449 PF15136.6 AAS52681.1 - 0.033 14.7 0.7 0.078 13.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Histone_H2A_C PF16211.5 AAS52682.1 - 4.5e-21 74.3 1.2 7.4e-21 73.6 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AAS52682.1 - 4.1e-18 66.0 0.0 5.6e-18 65.6 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AAS52682.1 - 3.1e-06 27.3 0.0 5.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 AAS52682.1 - 0.08 12.9 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 LcrG protein Histone PF00125.24 AAS52683.1 - 5.6e-21 75.3 3.1 7.4e-21 74.9 3.1 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AAS52683.1 - 6.7e-06 26.3 0.1 6.7e-06 26.3 0.1 1.7 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AAS52683.1 - 0.0018 18.7 0.0 0.0033 17.9 0.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AAS52683.1 - 0.011 16.0 0.0 0.016 15.4 0.0 1.2 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 AAS52683.1 - 0.041 13.9 0.2 0.047 13.7 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein RP-C PF03428.13 AAS52683.1 - 0.067 12.8 0.6 0.15 11.7 0.6 1.6 1 1 0 1 1 1 0 Replication protein C N-terminal domain Thiamine_BP PF01910.17 AAS52684.1 - 8.3e-31 105.8 0.1 9.4e-31 105.6 0.1 1.0 1 0 0 1 1 1 1 Thiamine-binding protein KDGP_aldolase PF07071.11 AAS52684.1 - 0.025 14.4 0.0 0.027 14.3 0.0 1.0 1 0 0 1 1 1 0 KDGP aldolase HTH_21 PF13276.6 AAS52684.1 - 0.084 13.0 0.1 0.22 11.7 0.0 1.7 2 0 0 2 2 2 0 HTH-like domain Trehalase PF01204.18 AAS52685.1 - 1.5e-187 624.5 0.0 1.8e-187 624.3 0.0 1.0 1 0 0 1 1 1 1 Trehalase Trehalase_Ca-bi PF07492.11 AAS52685.1 - 2.9e-16 58.9 0.4 4.7e-16 58.2 0.4 1.3 1 0 0 1 1 1 1 Neutral trehalase Ca2+ binding domain OCRE PF17780.1 AAS52685.1 - 0.52 10.4 3.7 0.27 11.3 0.6 2.1 2 0 0 2 2 2 0 OCRE domain Ran_BP1 PF00638.18 AAS52686.2 - 1.2e-54 183.8 1.1 1.8e-54 183.2 1.1 1.2 1 0 0 1 1 1 1 RanBP1 domain WH1 PF00568.23 AAS52686.2 - 2.2e-05 24.4 0.8 0.00027 20.8 0.8 2.1 1 1 0 1 1 1 1 WH1 domain VID27_PH PF17747.1 AAS52686.2 - 0.034 14.4 0.1 0.074 13.3 0.1 1.7 1 1 0 1 1 1 0 VID27 PH-like domain tRNA_synt_1c_R2 PF04557.15 AAS52686.2 - 2.7 9.0 9.7 1.7 9.6 5.3 2.5 2 1 1 3 3 3 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Prenyltransf PF01255.19 AAS52687.1 - 4.4e-74 248.8 0.0 5.4e-74 248.5 0.0 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Peptidase_M29 PF02073.15 AAS52687.1 - 0.084 11.6 0.1 0.11 11.2 0.1 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) polyprenyl_synt PF00348.17 AAS52688.2 - 1.9e-66 223.8 0.0 3.3e-65 219.7 0.0 2.4 1 1 0 1 1 1 1 Polyprenyl synthetase Mannosyl_trans2 PF04188.13 AAS52689.1 - 2.9e-66 224.6 35.1 2.2e-63 215.1 35.1 2.1 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) RCR PF12273.8 AAS52690.1 - 3.2e-28 98.8 3.0 4.3e-28 98.4 3.0 1.1 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red Aldedh PF00171.22 AAS52691.1 - 6.2e-160 532.7 0.0 7e-160 532.5 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF1487 PF07368.11 AAS52691.1 - 0.0094 15.4 0.0 0.016 14.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) Rad51 PF08423.11 AAS52692.1 - 2.2e-42 145.1 0.1 6.4e-39 133.8 0.0 2.2 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 AAS52692.1 - 1.9e-05 24.3 0.0 4.8e-05 23.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain RecA PF00154.21 AAS52692.1 - 6.6e-05 22.5 1.5 0.00034 20.2 1.5 2.0 1 1 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AAS52692.1 - 7.6e-05 22.2 0.2 0.00026 20.4 0.2 1.9 1 1 0 1 1 1 1 KaiC Spt20 PF12090.8 AAS52692.1 - 0.017 14.8 13.3 0.03 13.9 13.3 1.3 1 0 0 1 1 1 0 Spt20 family CobU PF02283.16 AAS52692.1 - 0.017 14.7 4.3 0.031 13.8 0.0 3.0 3 0 0 3 3 3 0 Cobinamide kinase / cobinamide phosphate guanyltransferase AIF_C PF14721.6 AAS52692.1 - 0.1 12.9 1.3 0.25 11.7 1.3 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Androgen_recep PF02166.16 AAS52692.1 - 2.8 6.7 9.6 4.2 6.1 9.6 1.2 1 0 0 1 1 1 0 Androgen receptor Hydin_ADK PF17213.3 AAS52692.1 - 4.7 7.4 8.6 3.7 7.8 6.4 1.9 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain GTA_holin_3TM PF11351.8 AAS52692.1 - 5.7 7.5 5.9 13 6.4 5.9 1.5 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Maf1 PF09174.10 AAS52693.1 - 3.1e-44 151.2 3.6 5.9e-42 143.8 3.6 2.2 1 1 0 1 1 1 1 Maf1 regulator Sel1 PF08238.12 AAS52694.2 - 1.2e-07 32.2 4.7 4.5e-05 24.0 0.5 3.8 5 0 0 5 5 5 2 Sel1 repeat RhoGEF67_u2 PF16614.5 AAS52694.2 - 0.045 13.8 0.6 0.14 12.2 0.6 1.8 1 0 0 1 1 1 0 Unstructured region two on RhoGEF 6 and 7 Tcp11 PF05794.13 AAS52695.2 - 2e-143 478.7 2.1 3.1e-143 478.0 2.1 1.3 1 0 0 1 1 1 1 T-complex protein 11 DUF3511 PF12023.8 AAS52695.2 - 0.23 11.3 0.8 1.2 9.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3511) CENP-T_C PF15511.6 AAS52696.2 - 2.6e-09 37.2 0.1 3.2e-09 36.9 0.1 1.2 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold Histone PF00125.24 AAS52696.2 - 2.8e-05 24.5 0.1 3.2e-05 24.3 0.1 1.3 1 1 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TAF PF02969.17 AAS52696.2 - 4.6e-05 23.5 0.2 6.8e-05 23.0 0.2 1.4 1 1 0 1 1 1 1 TATA box binding protein associated factor (TAF) CBFD_NFYB_HMF PF00808.23 AAS52696.2 - 8.8e-05 22.7 0.1 0.00016 21.9 0.0 1.6 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CENP-S PF15630.6 AAS52696.2 - 0.0002 21.6 0.1 0.00027 21.2 0.1 1.4 1 1 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AAS52696.2 - 0.0039 17.3 0.0 0.0046 17.0 0.0 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 AAS52696.2 - 0.0073 16.3 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Bromodomain associated TFIID_20kDa PF03847.13 AAS52696.2 - 0.044 14.3 0.1 0.075 13.5 0.1 1.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A Histone PF00125.24 AAS52697.1 - 3.1e-49 166.7 3.4 3.4e-49 166.5 3.4 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 AAS52697.1 - 2e-06 28.1 0.0 3e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 CENP-S protein PAF PF15715.5 AAS52697.1 - 5.5e-05 23.8 1.3 6.9e-05 23.5 1.3 1.2 1 0 0 1 1 1 1 PCNA-associated factor histone like domain CENP-T_C PF15511.6 AAS52697.1 - 0.00011 22.3 0.8 0.00015 21.9 0.1 1.6 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 AAS52697.1 - 0.0018 18.5 0.9 0.0023 18.2 0.1 1.6 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 AAS52697.1 - 0.035 14.2 0.2 0.058 13.5 0.0 1.5 2 0 0 2 2 2 0 Transcription initiation factor IID, 31kD subunit PRAI PF00697.22 AAS52698.1 - 9.7e-53 178.8 0.0 1.1e-52 178.7 0.0 1.0 1 0 0 1 1 1 1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Aldolase PF01081.19 AAS52698.1 - 0.0042 16.5 0.9 0.011 15.1 0.0 2.0 2 1 0 2 2 2 1 KDPG and KHG aldolase Pyrophosphatase PF00719.19 AAS52699.1 - 2.2e-59 199.8 0.1 2.9e-59 199.5 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase zf-ANAPC11 PF12861.7 AAS52700.1 - 9.2e-41 137.8 6.4 1.2e-40 137.5 6.4 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-rbx1 PF12678.7 AAS52700.1 - 4.7e-20 71.6 11.4 4.7e-20 71.6 11.4 1.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AAS52700.1 - 3e-06 27.5 19.1 6.3e-05 23.2 19.1 2.8 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 AAS52700.1 - 0.0021 18.0 13.5 0.052 13.5 14.5 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AAS52700.1 - 0.0033 17.4 11.2 0.017 15.2 8.2 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_4 PF14570.6 AAS52700.1 - 0.012 15.4 1.9 0.012 15.4 1.9 3.2 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain Zn_ribbon_17 PF17120.5 AAS52700.1 - 0.032 13.8 6.2 0.032 13.8 6.2 2.2 3 0 0 3 3 2 0 Zinc-ribbon, C4HC2 type zf-HIT PF04438.16 AAS52700.1 - 0.056 13.3 3.3 0.056 13.3 3.3 2.2 2 0 0 2 2 2 0 HIT zinc finger zf-C3HC4_2 PF13923.6 AAS52700.1 - 0.11 12.3 17.5 0.29 11.0 14.4 2.6 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS52700.1 - 0.2 11.6 19.2 0.24 11.3 16.5 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS52700.1 - 0.22 11.4 13.2 0.65 9.9 9.0 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H_2 PF13832.6 AAS52700.1 - 0.92 9.7 9.2 0.56 10.4 6.1 2.0 1 1 1 2 2 2 0 PHD-zinc-finger like domain FANCL_C PF11793.8 AAS52700.1 - 1.1 9.5 20.3 3.3 7.9 17.3 3.4 2 1 0 2 2 2 0 FANCL C-terminal domain zf-HC5HC2H PF13771.6 AAS52700.1 - 1.7 9.0 9.4 6.4 7.1 9.6 2.0 1 1 1 2 2 2 0 PHD-like zinc-binding domain Opy2 PF09463.10 AAS52700.1 - 2.9 8.3 11.9 0.52 10.7 6.4 2.3 2 0 0 2 2 2 0 Opy2 protein zf-RING-like PF08746.11 AAS52700.1 - 4.1 7.8 12.9 13 6.2 11.8 2.2 1 1 1 2 2 2 0 RING-like domain Glutaredoxin PF00462.24 AAS52701.2 - 5.1e-11 42.6 0.0 8.7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Glutaredoxin Mannosyl_trans3 PF11051.8 AAS52702.1 - 2e-82 276.6 0.0 3.2e-82 276.0 0.0 1.3 1 0 0 1 1 1 1 Mannosyltransferase putative NatB_MDM20 PF09797.9 AAS52703.1 - 5.7e-39 134.1 2.4 7.2e-38 130.5 2.4 2.2 1 1 0 1 1 1 1 N-acetyltransferase B complex (NatB) non catalytic subunit Brix PF04427.18 AAS52704.1 - 7.1e-43 147.0 0.2 9.8e-43 146.5 0.2 1.1 1 0 0 1 1 1 1 Brix domain ATP19 PF11022.8 AAS52705.1 - 2.6e-20 72.6 0.0 2.9e-20 72.4 0.0 1.0 1 0 0 1 1 1 1 ATP synthase subunit K Peptidase_S10 PF00450.22 AAS52706.1 - 5e-126 421.5 0.3 5.9e-126 421.3 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Calici_coat_C PF08435.11 AAS52706.1 - 0.089 12.3 0.1 0.17 11.4 0.1 1.4 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal CRIM PF16978.5 AAS52707.2 - 5.4e-35 120.6 0.0 1.6e-34 119.0 0.0 1.9 2 0 0 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SIN1_PH PF16979.5 AAS52707.2 - 2.1e-30 105.2 0.1 5.7e-30 103.8 0.1 1.7 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology PH PF00169.29 AAS52707.2 - 0.018 15.5 0.2 0.062 13.8 0.1 2.0 2 0 0 2 2 2 0 PH domain RNase_T PF00929.24 AAS52708.1 - 2.3e-17 64.0 0.0 4.4e-17 63.1 0.0 1.5 1 0 0 1 1 1 1 Exonuclease RasGAP PF00616.19 AAS52709.2 - 1.7e-22 80.2 0.1 1.5e-16 60.7 0.0 3.5 2 1 1 3 3 3 2 GTPase-activator protein for Ras-like GTPase Consortin_C PF15281.6 AAS52709.2 - 0.009 16.0 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 Consortin C-terminus MRP-S31 PF15433.6 AAS52709.2 - 0.06 13.0 0.1 0.11 12.1 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Bmt2 PF11968.8 AAS52710.1 - 2.2e-76 256.6 0.0 2.9e-76 256.2 0.0 1.2 1 0 0 1 1 1 1 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 Methyltransf_23 PF13489.6 AAS52710.1 - 0.0024 17.8 0.0 0.0045 16.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Pox_I3 PF04661.12 AAS52710.1 - 0.057 12.5 0.0 0.079 12.1 0.0 1.1 1 0 0 1 1 1 0 Poxvirus I3 ssDNA-binding protein DEAD PF00270.29 AAS52711.1 - 6e-38 130.4 0.0 1.3e-37 129.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52711.1 - 9e-30 103.3 0.0 1.8e-27 95.8 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52711.1 - 0.00021 21.4 0.0 0.00065 19.7 0.0 1.8 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Mig-14 PF07395.11 AAS52711.1 - 0.032 13.6 0.0 0.071 12.5 0.0 1.5 1 0 0 1 1 1 0 Mig-14 eRF1_2 PF03464.15 AAS52712.1 - 7.7e-46 155.7 0.2 1.3e-45 155.0 0.2 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 AAS52712.1 - 1.4e-38 131.8 0.8 3.6e-38 130.5 0.8 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 AAS52712.1 - 1.3e-18 67.2 0.0 2.4e-18 66.4 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 AAS52712.1 - 3.4e-10 40.3 0.0 5.2e-10 39.7 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 AAS52712.1 - 2.4e-08 34.3 0.0 4.5e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 ZZ PF00569.17 AAS52713.2 - 2.3e-12 46.5 37.2 3.5e-06 26.7 7.7 4.7 3 2 1 4 4 4 3 Zinc finger, ZZ type ATG19_autophagy PF12744.7 AAS52713.2 - 8.6e-12 44.8 0.0 4.1e-11 42.6 0.0 2.0 1 1 0 1 1 1 1 Autophagy protein Atg19, Atg8-binding MDMPI_N PF11716.8 AAS52713.2 - 0.013 16.2 0.0 0.031 14.9 0.0 1.6 1 0 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain RSN1_7TM PF02714.15 AAS52714.1 - 5.9e-79 265.2 29.6 5.9e-79 265.2 29.6 2.0 3 0 0 3 3 3 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AAS52714.1 - 1.7e-39 135.1 2.0 1.7e-39 135.1 2.0 3.9 4 1 1 5 5 5 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AAS52714.1 - 2.8e-23 83.1 0.1 4.1e-23 82.5 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 AAS52714.1 - 3.2e-21 75.3 0.1 3.2e-21 75.3 0.1 1.7 2 0 0 2 2 2 1 Extracellular tail, of 10TM putative phosphate transporter RRM_1 PF00076.22 AAS52714.1 - 0.096 12.5 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Gp_dh_C PF02800.20 AAS52715.2 - 2.5e-71 238.4 0.0 4.2e-71 237.7 0.0 1.4 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 AAS52715.2 - 6.4e-40 135.6 0.1 1.3e-39 134.5 0.1 1.6 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 AAS52715.2 - 0.023 14.8 1.3 0.046 13.8 0.5 2.1 2 1 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus 2-Hacid_dh_C PF02826.19 AAS52715.2 - 0.063 12.6 0.1 0.13 11.6 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ADH_N PF08240.12 AAS52716.1 - 2e-29 101.7 0.3 4.8e-29 100.4 0.3 1.7 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS52716.1 - 9.5e-25 87.1 0.7 1.5e-24 86.5 0.7 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AAS52716.1 - 4.9e-07 30.9 0.1 8.3e-07 30.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Ribosomal_S9 PF00380.19 AAS52717.1 - 7.1e-44 149.2 0.7 1.3e-43 148.4 0.7 1.4 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CHASE3 PF05227.13 AAS52717.1 - 0.035 14.0 0.2 0.12 12.3 0.1 1.9 2 0 0 2 2 2 0 CHASE3 domain Nitrate_red_del PF02613.15 AAS52717.1 - 0.054 13.5 0.1 0.12 12.4 0.0 1.5 2 0 0 2 2 2 0 Nitrate reductase delta subunit CENP-S PF15630.6 AAS52718.1 - 1.6e-25 89.2 0.0 2e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 AAS52718.1 - 1.7e-06 28.1 0.0 2.1e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold DUF3433 PF11915.8 AAS52718.1 - 0.012 16.1 0.0 0.071 13.6 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3433) DUF3337 PF11816.8 AAS52719.2 - 2.8e-28 98.9 0.1 7.8e-28 97.5 0.2 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3337) WD40 PF00400.32 AAS52719.2 - 0.0003 21.5 6.9 0.26 12.2 0.1 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat RAWUL PF16207.5 AAS52719.2 - 0.012 16.3 0.1 0.025 15.3 0.1 1.6 1 0 0 1 1 1 0 RAWUL domain RING finger- and WD40-associated ubiquitin-like RNA_pol_Rpb5_C PF01191.19 AAS52720.1 - 8.6e-33 112.0 0.5 1.8e-32 111.0 0.5 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 AAS52720.1 - 3.2e-30 104.5 0.3 6.3e-30 103.6 0.3 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb5, N-terminal domain Sof1 PF04158.14 AAS52720.1 - 0.014 15.7 0.2 0.026 14.8 0.2 1.4 1 0 0 1 1 1 0 Sof1-like domain RibD_C PF01872.17 AAS52721.1 - 2.6e-34 118.8 0.0 2.9e-34 118.7 0.0 1.0 1 0 0 1 1 1 1 RibD C-terminal domain MFAP1 PF06991.11 AAS52722.1 - 2e-05 24.5 10.3 2e-05 24.5 10.3 1.9 1 1 1 2 2 2 1 Microfibril-associated/Pre-mRNA processing DUF4733 PF15878.5 AAS52722.1 - 0.05 14.1 0.2 0.12 12.9 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4733) Thioredoxin PF00085.20 AAS52723.2 - 3.1e-12 46.4 0.0 3.5e-11 43.0 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 AAS52723.2 - 0.19 12.0 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like Suc_Fer-like PF06999.12 AAS52724.1 - 1.5e-46 158.7 0.0 1.9e-46 158.4 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like zf-nanos PF05741.13 AAS52724.1 - 0.056 13.7 0.4 0.14 12.4 0.4 1.6 1 0 0 1 1 1 0 Nanos RNA binding domain CRAL_TRIO PF00650.20 AAS52725.2 - 1e-44 152.1 0.0 2e-44 151.1 0.0 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AAS52725.2 - 6e-11 42.4 0.2 1.8e-10 40.9 0.2 1.9 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain CRAL_TRIO_2 PF13716.6 AAS52725.2 - 0.0016 18.6 0.0 0.0033 17.6 0.0 1.5 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain tRNA-synt_1 PF00133.22 AAS52727.1 - 8.1e-46 156.5 0.0 3.9e-24 84.9 0.3 6.0 2 1 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 AAS52727.1 - 2.1e-26 92.6 0.0 3.3e-26 91.9 0.0 1.3 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 AAS52727.1 - 6.8e-25 87.6 0.2 2.8e-19 69.1 0.0 4.4 4 1 1 5 5 5 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AAS52727.1 - 0.00018 21.5 0.0 0.00036 20.5 0.0 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AAS52727.1 - 0.0051 16.2 0.0 0.82 8.9 0.0 2.7 3 0 0 3 3 3 1 tRNA synthetases class I (C) catalytic domain zf-ribbon_3 PF13248.6 AAS52727.1 - 0.036 13.5 2.2 5.2 6.6 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.7 AAS52727.1 - 0.055 13.5 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Double zinc ribbon tRNA-synt_1d PF00750.19 AAS52727.1 - 0.059 12.3 0.0 0.1 11.5 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (R) Zn-ribbon_8 PF09723.10 AAS52727.1 - 0.2 11.8 0.9 3 8.0 0.1 2.7 2 0 0 2 2 2 0 Zinc ribbon domain SMC_N PF02463.19 AAS52728.1 - 5.6e-28 97.9 0.0 3.7e-27 95.2 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AAS52728.1 - 1.6e-12 47.8 18.2 1.6e-12 47.8 18.2 3.4 2 2 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.6 AAS52728.1 - 8.5e-11 42.7 39.3 8.5e-11 42.7 39.3 4.8 2 2 0 2 2 1 1 AAA domain AAA_21 PF13304.6 AAS52728.1 - 1.3e-06 28.5 6.2 0.00037 20.4 0.2 3.5 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AAS52728.1 - 9.3e-05 22.1 0.0 0.00022 20.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 AAS52728.1 - 0.00037 19.3 59.8 0.01 14.5 21.3 5.1 4 1 1 5 5 5 3 AAA domain ADIP PF11559.8 AAS52728.1 - 0.0013 18.9 15.5 0.0013 18.9 15.5 6.5 4 2 1 7 7 6 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 AAS52728.1 - 0.0045 17.3 10.3 0.0045 17.3 10.3 6.0 3 2 4 7 7 7 1 Autophagy protein 16 (ATG16) AAA_27 PF13514.6 AAS52728.1 - 0.009 15.6 0.0 0.009 15.6 0.0 4.7 5 1 0 5 5 5 1 AAA domain SMC_hinge PF06470.13 AAS52728.1 - 0.014 15.7 0.0 0.044 14.1 0.0 1.9 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Ploopntkinase3 PF18751.1 AAS52728.1 - 0.024 14.5 0.0 0.067 13.1 0.0 1.7 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 ABC_tran PF00005.27 AAS52728.1 - 0.098 13.2 0.0 0.098 13.2 0.0 5.1 3 2 0 3 3 2 0 ABC transporter DUF948 PF06103.11 AAS52728.1 - 0.46 10.8 0.0 0.46 10.8 0.0 5.4 5 0 0 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF3584 PF12128.8 AAS52728.1 - 0.99 6.8 62.8 0.026 12.1 10.7 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF3584) Glutaredoxin2_C PF04399.13 AAS52728.1 - 1.7 8.5 8.6 0.36 10.7 0.1 3.4 3 0 0 3 3 3 0 Glutaredoxin 2, C terminal domain Spc7 PF08317.11 AAS52728.1 - 2.1 7.2 69.5 0.14 11.0 28.4 5.7 2 2 4 6 6 6 0 Spc7 kinetochore protein DUF1664 PF07889.12 AAS52728.1 - 6.6 6.8 46.2 0.42 10.7 4.8 7.1 5 2 3 8 8 8 0 Protein of unknown function (DUF1664) Uso1_p115_head PF04869.14 AAS52729.1 - 4.5e-91 305.2 0.9 1.3e-90 303.8 0.1 2.3 2 0 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Uso1_p115_C PF04871.13 AAS52729.1 - 1.5e-15 57.6 27.1 1.5e-15 57.6 27.1 7.6 1 1 6 7 7 4 2 Uso1 / p115 like vesicle tethering protein, C terminal region Arm_vescicular PF18770.1 AAS52729.1 - 4.1e-06 26.6 0.0 7.5e-05 22.6 0.0 2.7 2 0 0 2 2 2 1 Armadillo tether-repeat of vescicular transport factor Spc7 PF08317.11 AAS52729.1 - 0.00074 18.5 130.6 0.045 12.6 26.5 5.4 1 1 2 5 5 5 5 Spc7 kinetochore protein HEAT_2 PF13646.6 AAS52729.1 - 0.0009 19.6 0.8 0.021 15.2 0.0 3.3 3 0 0 3 3 3 1 HEAT repeats Fib_alpha PF08702.10 AAS52729.1 - 0.0056 16.9 10.5 0.0056 16.9 10.5 6.8 1 1 4 6 6 6 2 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 AAS52729.1 - 0.0071 16.3 4.4 0.0071 16.3 4.4 11.5 4 3 6 10 10 9 2 TATA element modulatory factor 1 DNA binding APG6_N PF17675.1 AAS52729.1 - 0.0085 16.6 22.5 0.0085 16.6 22.5 7.7 1 1 6 7 7 7 2 Apg6 coiled-coil region ATG16 PF08614.11 AAS52729.1 - 0.046 13.9 131.6 0.11 12.7 26.2 6.5 1 1 5 6 6 6 0 Autophagy protein 16 (ATG16) CinA_KH PF18146.1 AAS52729.1 - 0.17 12.0 1.2 1.1 9.4 1.2 2.5 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain HEAT_EZ PF13513.6 AAS52729.1 - 0.23 12.0 0.6 8.8 7.0 0.0 3.8 5 0 0 5 5 4 0 HEAT-like repeat CENP-F_leu_zip PF10473.9 AAS52729.1 - 0.61 10.1 134.7 2.3 8.2 14.2 7.5 1 1 6 7 7 7 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 AAS52729.1 - 0.91 9.8 116.6 0.083 13.1 14.8 8.1 1 1 7 9 9 9 0 TATA element modulatory factor 1 TATA binding GAS PF13851.6 AAS52729.1 - 2.3 7.5 132.7 0.05 12.9 14.8 7.3 1 1 6 7 7 7 0 Growth-arrest specific micro-tubule binding TetR_C_24 PF17932.1 AAS52729.1 - 7.3 6.9 5.8 33 4.8 0.2 4.4 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Rad52_Rad22 PF04098.15 AAS52730.1 - 5.6e-44 149.8 0.1 6.6e-44 149.5 0.1 1.1 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein IKI3 PF04762.12 AAS52731.2 - 0 1145.7 0.0 0 1145.5 0.0 1.1 1 0 0 1 1 1 1 IKI3 family ANAPC4_WD40 PF12894.7 AAS52731.2 - 0.06 13.6 0.1 19 5.6 0.0 4.0 4 0 0 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Rav1p_C PF12234.8 AAS52731.2 - 0.066 11.6 1.0 1.3 7.3 0.0 2.7 3 0 0 3 3 3 0 RAVE protein 1 C terminal Ribosomal_L21e PF01157.18 AAS52731.2 - 0.071 13.0 0.2 0.24 11.3 0.0 2.0 2 0 0 2 2 2 0 Ribosomal protein L21e TPR_7 PF13176.6 AAS52731.2 - 0.092 12.8 0.1 0.81 9.9 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 AAS52731.2 - 0.65 10.3 0.0 0.65 10.3 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat SWC7 PF17330.2 AAS52732.1 - 1e-36 124.9 0.1 1.3e-36 124.6 0.1 1.1 1 0 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 Vac14_Fig4_bd PF11916.8 AAS52733.2 - 2.6e-69 232.4 3.8 2.6e-69 232.4 3.8 1.9 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Vac14_Fab1_bd PF12755.7 AAS52733.2 - 4.5e-47 158.6 3.4 1.2e-38 131.6 0.2 4.4 4 0 0 4 4 4 2 Vacuolar 14 Fab1-binding region HEAT PF02985.22 AAS52733.2 - 4.3e-14 51.4 3.6 0.0013 18.8 0.0 7.2 7 0 0 7 7 6 3 HEAT repeat CLASP_N PF12348.8 AAS52733.2 - 3.7e-08 33.2 2.7 0.0021 17.6 0.4 4.6 3 3 2 5 5 5 2 CLASP N terminal HEAT_2 PF13646.6 AAS52733.2 - 2.4e-07 31.1 0.0 0.39 11.1 0.0 5.9 5 2 1 6 6 6 1 HEAT repeats MMS19_C PF12460.8 AAS52733.2 - 2e-06 27.2 11.7 0.036 13.2 0.9 4.4 4 0 0 4 4 4 2 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 AAS52733.2 - 5.9e-05 23.5 0.7 0.1 13.2 0.0 4.1 6 0 0 6 6 3 1 HEAT-like repeat Cnd1 PF12717.7 AAS52733.2 - 0.00018 21.6 13.9 0.56 10.2 0.3 4.6 4 1 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RIX1 PF08167.12 AAS52733.2 - 0.00025 20.8 3.1 0.0018 18.1 0.5 3.1 2 0 0 2 2 2 1 rRNA processing/ribosome biogenesis Tti2 PF10521.9 AAS52733.2 - 0.0053 16.3 7.4 0.48 9.9 0.2 4.8 4 0 0 4 4 4 1 Tti2 family Arm PF00514.23 AAS52733.2 - 0.011 15.8 0.3 5.6 7.2 0.0 4.1 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat TAF6_C PF07571.13 AAS52733.2 - 0.015 15.6 1.0 0.58 10.5 0.0 3.6 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain RTP1_C1 PF10363.9 AAS52733.2 - 0.092 12.9 7.4 4.6 7.5 0.1 4.6 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF3361 PF11841.8 AAS52733.2 - 0.093 12.7 3.2 9.8 6.1 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3361) RasGEF_N_2 PF14663.6 AAS52733.2 - 0.26 11.7 9.6 2.6 8.5 0.2 4.9 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Nipped-B_C PF12830.7 AAS52733.2 - 0.9 9.5 5.5 6.8 6.6 0.3 3.6 3 1 1 4 4 4 0 Sister chromatid cohesion C-terminus TAFH PF07531.14 AAS52733.2 - 7 6.8 8.1 10 6.3 0.6 3.6 3 1 0 3 3 3 0 NHR1 homology to TAF zf-C2H2_2 PF12756.7 AAS52734.1 - 2.3e-28 98.5 6.8 1.6e-26 92.5 2.0 2.5 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) DUF488 PF04343.13 AAS52734.1 - 0.075 13.6 0.2 0.16 12.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF488 RIBIOP_C PF04950.12 AAS52735.1 - 2.4e-101 339.0 0.0 3.8e-101 338.4 0.0 1.3 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AAS52735.1 - 4.7e-20 71.5 0.0 1.1e-19 70.3 0.0 1.7 1 0 0 1 1 1 1 AARP2CN (NUC121) domain Ribosomal_S14 PF00253.21 AAS52736.1 - 1.5e-17 63.1 2.7 1.7e-17 62.9 2.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S14p/S29e Prim_Zn_Ribbon PF08273.12 AAS52736.1 - 0.027 14.7 1.6 3 8.2 0.2 2.1 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase Peptidase_M16_M PF16187.5 AAS52737.2 - 2.8e-86 289.3 2.2 3.3e-86 289.1 0.3 2.0 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16 PF00675.20 AAS52737.2 - 2.4e-42 144.5 0.2 1.3e-41 142.0 0.1 2.2 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AAS52737.2 - 3.4e-31 108.7 5.1 3.1e-19 69.7 0.1 3.0 3 0 0 3 3 3 2 Peptidase M16 inactive domain CorC_HlyC PF03471.17 AAS52737.2 - 0.091 12.8 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Transporter associated domain MCM_N PF14551.6 AAS52739.1 - 0.0049 17.4 0.8 0.46 11.1 0.0 3.4 3 0 0 3 3 3 1 MCM N-terminal domain Arm PF00514.23 AAS52739.1 - 0.24 11.5 5.2 3.9 7.7 0.0 3.7 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat UQ_con PF00179.26 AAS52740.1 - 4.1e-45 152.9 0.2 4.6e-45 152.7 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS52740.1 - 4e-05 23.3 0.0 4.6e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic E2 family B Pex19 PF04614.12 AAS52741.1 - 6.8e-58 196.3 12.9 6.8e-58 196.3 12.9 1.7 2 0 0 2 2 2 1 Pex19 protein family GET2 PF08690.10 AAS52741.1 - 0.038 13.7 15.3 0.43 10.2 3.1 2.3 1 1 1 2 2 2 0 GET complex subunit GET2 GlutR_dimer PF00745.20 AAS52741.1 - 0.48 10.9 4.4 14 6.2 0.2 3.6 3 1 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain Sigma70_ner PF04546.13 AAS52741.1 - 1.4 8.8 17.2 4.9 7.0 0.1 2.7 2 1 0 2 2 2 0 Sigma-70, non-essential region CFEM PF05730.11 AAS52742.2 - 0.0002 21.4 5.3 0.00043 20.3 5.3 1.6 1 0 0 1 1 1 1 CFEM domain Macoilin PF09726.9 AAS52742.2 - 2.5 6.5 14.0 3.4 6.1 14.0 1.3 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 AAS52742.2 - 7.2 4.6 7.9 8.5 4.4 7.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SOG2 PF10428.9 AAS52742.2 - 7.3 5.7 25.7 8.6 5.4 25.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Plasmodium_Vir PF05795.11 AAS52742.2 - 7.7 5.8 7.8 9.6 5.5 7.8 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Apt1 PF10351.9 AAS52742.2 - 9.9 4.9 13.4 12 4.6 13.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Arrestin_N PF00339.29 AAS52743.1 - 1.7e-05 24.9 0.0 0.00032 20.8 0.0 2.4 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain ATP-synt_10 PF05176.14 AAS52744.2 - 3.7e-92 308.2 0.0 4.2e-92 308.0 0.0 1.0 1 0 0 1 1 1 1 ATP10 protein Iso_dh PF00180.20 AAS52745.1 - 4.4e-69 233.3 0.0 5.1e-69 233.1 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase COX7C PF02935.16 AAS52746.1 - 9.2e-25 86.7 1.9 1.1e-24 86.5 1.9 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIIc COX6C PF02937.15 AAS52747.1 - 0.0055 16.8 0.0 0.0064 16.6 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIc Sec1 PF00995.23 AAS52748.1 - 2.5e-73 248.3 0.0 3.3e-73 247.8 0.0 1.1 1 0 0 1 1 1 1 Sec1 family AAA PF00004.29 AAS52749.2 - 8.2e-87 288.4 0.0 8.5e-42 142.7 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS52749.2 - 6e-17 61.2 3.6 1.3e-08 34.5 1.3 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AAS52749.2 - 1.4e-14 54.1 0.0 5.9e-06 26.1 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AAS52749.2 - 3.3e-12 47.1 1.3 1.7e-06 28.5 0.2 4.0 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 AAS52749.2 - 1.1e-10 41.7 0.2 0.001 19.1 0.0 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AAS52749.2 - 1.8e-10 41.3 3.0 0.0001 22.6 0.1 4.6 2 2 0 3 3 3 1 AAA domain AAA_2 PF07724.14 AAS52749.2 - 5.8e-10 39.5 0.0 0.00024 21.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) Bac_DnaA PF00308.18 AAS52749.2 - 1.2e-07 31.8 0.0 0.0012 18.8 0.0 2.3 2 0 0 2 2 2 2 Bacterial dnaA protein AAA_33 PF13671.6 AAS52749.2 - 1.6e-07 31.6 0.0 0.00092 19.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain CDC48_N PF02359.18 AAS52749.2 - 2.4e-07 30.9 0.1 6.4e-07 29.5 0.1 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain Rad17 PF03215.15 AAS52749.2 - 6.7e-07 29.4 0.0 0.014 15.3 0.0 2.9 2 1 0 2 2 2 2 Rad17 P-loop domain AAA_14 PF13173.6 AAS52749.2 - 2.8e-06 27.4 0.0 0.013 15.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AAS52749.2 - 2e-05 24.0 0.0 0.044 13.0 0.0 2.6 3 0 0 3 3 3 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AAS52749.2 - 5e-05 22.8 0.5 0.13 11.6 0.1 2.8 3 0 0 3 3 2 2 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AAS52749.2 - 6.2e-05 23.6 0.0 0.57 10.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AAS52749.2 - 0.00012 22.4 0.0 1 9.8 0.0 2.9 2 1 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AAS52749.2 - 0.00017 21.9 0.0 0.82 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AAS52749.2 - 0.00026 21.0 0.4 0.13 12.1 0.0 3.8 4 0 0 4 4 4 1 NACHT domain AAA_11 PF13086.6 AAS52749.2 - 0.00028 20.8 0.0 0.21 11.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_3 PF07726.11 AAS52749.2 - 0.00028 20.7 0.0 0.63 9.9 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 AAS52749.2 - 0.00036 20.5 0.0 2.6 7.9 0.0 3.4 2 2 1 3 3 3 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 AAS52749.2 - 0.00098 18.9 0.0 0.93 9.2 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein TniB PF05621.11 AAS52749.2 - 0.0011 18.4 0.0 6.8 6.1 0.0 3.6 3 1 1 4 4 3 0 Bacterial TniB protein TsaE PF02367.17 AAS52749.2 - 0.0013 18.8 0.0 0.39 10.7 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 AAS52749.2 - 0.0018 18.8 0.0 0.03 14.8 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_25 PF13481.6 AAS52749.2 - 0.0027 17.3 5.9 2.8 7.5 0.0 4.2 2 2 1 3 3 3 1 AAA domain AAA_7 PF12775.7 AAS52749.2 - 0.0035 16.9 0.0 1 8.9 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 AAS52749.2 - 0.0048 16.6 0.0 1.8 8.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.6 AAS52749.2 - 0.0049 17.0 0.0 1.1 9.4 0.0 2.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_19 PF13245.6 AAS52749.2 - 0.0065 16.8 0.5 0.2 12.0 0.0 3.0 2 2 0 3 3 2 1 AAA domain AFG1_ATPase PF03969.16 AAS52749.2 - 0.019 13.9 0.0 0.12 11.3 0.0 2.1 2 0 0 2 2 2 0 AFG1-like ATPase AAA_30 PF13604.6 AAS52749.2 - 0.019 14.7 0.0 0.31 10.7 0.0 2.8 2 1 0 2 2 2 0 AAA domain DUF815 PF05673.13 AAS52749.2 - 0.026 13.7 0.0 2.1 7.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Viral_helicase1 PF01443.18 AAS52749.2 - 0.035 13.8 0.0 0.2 11.4 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 AAS52749.2 - 0.043 13.1 0.0 2.7 7.2 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin ATPase PF06745.13 AAS52749.2 - 0.058 12.7 0.4 16 4.8 0.0 3.5 4 0 0 4 4 4 0 KaiC Sigma54_activat PF00158.26 AAS52749.2 - 0.09 12.5 0.0 16 5.2 0.0 3.4 3 0 0 3 3 3 0 Sigma-54 interaction domain Phage-tail_2 PF09096.10 AAS52750.1 - 0.012 15.6 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 Baseplate structural protein, domain 2 DSHCT PF08148.12 AAS52751.2 - 4.9e-47 159.6 0.3 1.4e-46 158.1 0.2 1.9 2 0 0 2 2 2 1 DSHCT (NUC185) domain Ski2_N PF17911.1 AAS52751.2 - 3.1e-38 130.6 0.0 8.5e-38 129.2 0.0 1.8 1 0 0 1 1 1 1 Ski2 N-terminal region DEAD PF00270.29 AAS52751.2 - 1.5e-20 73.7 0.1 3.7e-20 72.4 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase rRNA_proc-arch PF13234.6 AAS52751.2 - 6.2e-17 62.4 1.2 1.1e-16 61.6 1.2 1.5 1 0 0 1 1 1 1 rRNA-processing arch domain Helicase_C PF00271.31 AAS52751.2 - 1.4e-07 31.9 0.0 6e-07 29.8 0.0 2.2 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52751.2 - 1.5e-06 28.3 0.0 3.8e-06 27.0 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Bromodomain PF00439.25 AAS52752.2 - 3.6e-41 139.1 0.1 3.4e-20 71.9 0.0 2.4 2 0 0 2 2 2 2 Bromodomain BET PF17035.5 AAS52752.2 - 4e-20 71.7 0.1 1.1e-19 70.3 0.1 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Bap31 PF05529.12 AAS52753.1 - 4.2e-35 120.5 5.2 5.4e-35 120.2 5.2 1.1 1 0 0 1 1 1 1 Bap31/Bap29 transmembrane region Bap31_Bap29_C PF18035.1 AAS52753.1 - 1.4 9.0 3.3 0.48 10.5 0.6 1.6 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Dus PF01207.17 AAS52754.1 - 6.9e-49 166.6 0.0 3.9e-47 160.8 0.0 2.2 1 1 0 1 1 1 1 Dihydrouridine synthase (Dus) zf-CCCH_4 PF18044.1 AAS52754.1 - 4.8e-07 29.4 9.2 0.0023 17.7 0.1 3.0 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH PF00642.24 AAS52754.1 - 0.00017 21.4 10.0 0.0013 18.6 0.2 3.3 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 AAS52754.1 - 0.012 16.2 9.5 0.03 15.0 1.7 2.7 1 1 1 2 2 2 0 Torus domain zf_CCCH_4 PF18345.1 AAS52754.1 - 0.058 13.5 6.2 0.091 12.9 0.4 2.8 2 0 0 2 2 2 0 Zinc finger domain zf-C2H2_aberr PF17017.5 AAS52755.2 - 4.6e-05 23.6 6.1 0.002 18.3 0.4 2.3 2 0 0 2 2 2 2 Aberrant zinc-finger zf-C2H2_4 PF13894.6 AAS52755.2 - 0.00018 22.1 12.7 0.051 14.4 0.6 4.0 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS52755.2 - 0.00026 21.3 13.9 0.03 14.8 1.4 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 AAS52755.2 - 0.0037 17.5 4.1 1.3 9.4 0.1 3.2 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding DUF3246 PF11596.8 AAS52755.2 - 0.093 12.1 5.3 0.22 10.9 5.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) PBP1_TM PF14812.6 AAS52755.2 - 0.13 12.6 6.9 0.32 11.4 6.9 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-met PF12874.7 AAS52755.2 - 0.16 12.4 3.1 3 8.4 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AAS52755.2 - 0.16 12.4 19.3 0.2 12.2 1.7 3.8 3 0 0 3 3 3 0 Zinc-finger double domain T4BSS_DotI_IcmL PF11393.8 AAS52755.2 - 0.22 11.0 1.2 2.1 7.8 0.2 2.2 2 0 0 2 2 2 0 Type-IV b secretion system, inner-membrane complex component zf-C2H2_6 PF13912.6 AAS52755.2 - 4.7 7.3 10.1 3.3 7.8 1.8 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger Stealth_CR4 PF17103.5 AAS52756.2 - 0.052 13.4 0.1 0.096 12.6 0.1 1.3 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Seipin PF06775.14 AAS52756.2 - 0.13 12.4 0.9 0.71 9.9 0.2 2.2 1 1 0 2 2 2 0 Putative adipose-regulatory protein (Seipin) DUF1765 PF08578.10 AAS52757.2 - 1.8e-22 80.1 3.1 1.9e-22 80.0 0.4 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) DUF1117 PF06547.12 AAS52757.2 - 0.29 11.7 6.0 29 5.3 4.5 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) Macoilin PF09726.9 AAS52757.2 - 2.7 6.5 9.1 4 5.9 9.1 1.3 1 0 0 1 1 1 0 Macoilin family BRE1 PF08647.11 AAS52758.1 - 1.7e-27 95.3 19.2 1.7e-27 95.3 19.2 5.5 4 2 0 4 4 3 2 BRE1 E3 ubiquitin ligase zf-C3HC4_3 PF13920.6 AAS52758.1 - 8.3e-08 32.0 10.1 1.4e-07 31.2 10.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS52758.1 - 6.1e-07 29.2 12.0 1.1e-06 28.4 12.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS52758.1 - 1.2e-06 28.3 9.2 2e-06 27.6 9.2 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 AAS52758.1 - 1.2e-05 25.1 12.7 2.1e-05 24.3 12.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS52758.1 - 1.5e-05 24.9 12.5 2.6e-05 24.1 12.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AAS52758.1 - 0.00025 21.3 11.7 0.00046 20.5 11.7 1.5 1 0 0 1 1 1 1 Ring finger domain ZapB PF06005.12 AAS52758.1 - 0.0027 18.1 1.3 0.0027 18.1 1.3 7.8 5 2 1 7 7 6 2 Cell division protein ZapB zf-RING_UBOX PF13445.6 AAS52758.1 - 0.0035 17.3 10.0 0.0069 16.4 10.0 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-C2H2_jaz PF12171.8 AAS52758.1 - 0.0048 17.2 0.9 0.21 11.9 0.0 2.9 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 AAS52758.1 - 0.01 16.3 0.1 0.01 16.3 0.1 2.8 4 0 0 4 4 2 0 Zinc finger, C2H2 type STAT_alpha PF01017.20 AAS52758.1 - 0.012 15.6 4.7 0.012 15.6 4.7 4.1 3 1 1 4 4 4 0 STAT protein, all-alpha domain zf-C2H2_4 PF13894.6 AAS52758.1 - 0.012 16.4 1.6 0.4 11.6 0.1 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger zf-rbx1 PF12678.7 AAS52758.1 - 0.13 12.6 8.5 0.31 11.4 8.5 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 AAS52758.1 - 0.91 9.4 9.8 1.7 8.5 9.8 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 AAS52758.1 - 0.92 9.7 9.2 1.8 8.8 9.2 1.5 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 AAS52758.1 - 1.1 9.1 4.9 2.3 8.2 4.9 1.4 1 0 0 1 1 1 0 zf-RING of BARD1-type protein FYVE PF01363.21 AAS52758.1 - 9.2 6.5 13.0 80 3.5 13.0 2.4 1 1 0 1 1 1 0 FYVE zinc finger Dus PF01207.17 AAS52759.1 - 1.2e-80 270.9 0.0 1.5e-80 270.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Resolvase PF00239.21 AAS52759.1 - 0.0098 16.0 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 1 Resolvase, N terminal domain PEP_mutase PF13714.6 AAS52759.1 - 0.044 13.2 0.3 0.19 11.2 0.1 2.0 1 1 1 2 2 2 0 Phosphoenolpyruvate phosphomutase TMP-TENI PF02581.17 AAS52759.1 - 0.059 12.7 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 Thiamine monophosphate synthase Ribosomal_L31e PF01198.19 AAS52760.2 - 3.6e-40 136.1 1.0 4.5e-40 135.8 1.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L31e Rxt3 PF08642.10 AAS52761.1 - 3.8e-23 82.6 0.0 2e-22 80.3 0.0 2.0 1 1 0 1 1 1 1 Histone deacetylation protein Rxt3 DUF4050 PF13259.6 AAS52762.1 - 9.9e-12 45.5 11.1 5.9e-09 36.5 11.1 2.9 1 1 0 1 1 1 1 Protein of unknown function (DUF4050) GCN5L1 PF06320.13 AAS52763.1 - 0.0027 17.8 0.1 0.0042 17.2 0.1 1.5 1 1 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) PilJ PF13675.6 AAS52763.1 - 0.066 13.2 0.4 0.15 12.1 0.1 1.7 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Vps39_1 PF10366.9 AAS52764.1 - 1.5e-36 125.0 1.9 1.3e-35 122.0 1.9 2.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 AAS52764.1 - 4.8e-14 52.7 0.0 1.3e-13 51.4 0.0 1.8 1 0 0 1 1 1 1 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 AAS52764.1 - 0.0017 18.3 19.4 0.004 17.0 2.3 3.8 4 1 0 4 4 4 2 Region in Clathrin and VPS Utp21 PF04192.12 AAS52765.2 - 2.5e-75 253.0 2.2 4.3e-75 252.2 2.2 1.4 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain ANAPC4_WD40 PF12894.7 AAS52765.2 - 1.9e-16 60.2 0.3 0.00018 21.7 0.0 6.3 6 1 2 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS52765.2 - 1.8e-10 41.2 20.8 5.1e-07 30.3 0.5 9.0 9 0 0 9 9 9 2 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 AAS52765.2 - 2.5e-05 23.0 0.1 0.00046 18.8 0.0 2.3 2 0 0 2 2 2 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 AAS52765.2 - 0.00017 21.3 0.2 0.016 14.8 0.0 3.1 3 0 0 3 3 3 1 PQQ-like domain eIF2A PF08662.11 AAS52765.2 - 0.0034 17.3 0.5 2.8 7.8 0.0 3.9 3 1 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 AAS52765.2 - 0.059 12.4 0.0 5 6.1 0.0 2.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain CPSF_A PF03178.15 AAS52765.2 - 0.065 12.5 0.0 0.25 10.6 0.0 2.0 1 0 0 1 1 1 0 CPSF A subunit region PD40 PF07676.12 AAS52765.2 - 0.3 11.1 1.8 1 9.4 0.1 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat His_Phos_2 PF00328.22 AAS52766.1 - 1.9e-141 471.9 0.2 3.3e-141 471.1 0.2 1.4 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 AAS52766.1 - 4.1e-37 126.2 0.1 1.1e-36 124.9 0.1 1.8 1 0 0 1 1 1 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 AAS52766.1 - 3.1e-08 33.4 0.0 7.6e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 RimK-like ATP-grasp domain SPX PF03105.19 AAS52766.1 - 2.1 8.2 6.3 3.9 7.3 6.3 1.3 1 0 0 1 1 1 0 SPX domain Pribosyl_synth PF14572.6 AAS52767.1 - 1.6e-39 135.8 2.9 2.5e-31 109.1 0.2 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AAS52767.1 - 2.2e-39 134.0 0.1 1.2e-38 131.6 0.0 2.2 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AAS52767.1 - 1.5e-07 31.1 0.1 6.8e-06 25.7 0.1 2.3 1 1 0 1 1 1 1 Phosphoribosyl transferase domain SRR1 PF07985.12 AAS52768.1 - 1.4e-16 60.3 0.1 2.4e-16 59.5 0.1 1.4 1 0 0 1 1 1 1 SRR1 DUF1729 PF08354.10 AAS52769.2 - 1.2e-153 511.2 0.0 2.1e-153 510.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1729) Acyl_transf_1 PF00698.21 AAS52769.2 - 4.5e-104 348.4 0.0 5.2e-103 344.9 0.0 2.8 3 0 0 3 3 3 1 Acyl transferase domain FAS_meander PF17951.1 AAS52769.2 - 1e-42 145.4 0.0 2.9e-42 143.9 0.0 1.8 1 0 0 1 1 1 1 Fatty acid synthase meander beta sheet domain SAT PF16073.5 AAS52769.2 - 1.6e-39 136.1 0.0 5.7e-39 134.3 0.0 1.9 2 0 0 2 2 2 1 Starter unit:ACP transacylase in aflatoxin biosynthesis MaoC_dehydratas PF01575.19 AAS52769.2 - 6.5e-37 125.8 0.0 1.4e-36 124.8 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain FAS_N PF17828.1 AAS52769.2 - 2.6e-26 92.2 0.0 6.9e-26 90.8 0.0 1.7 1 0 0 1 1 1 1 N-terminal domain in fatty acid synthase subunit beta MaoC_dehydrat_N PF13452.6 AAS52769.2 - 4.4e-14 52.8 0.0 2.2e-13 50.5 0.0 2.2 3 0 0 3 3 3 1 N-terminal half of MaoC dehydratase Lipase_3 PF01764.25 AAS52769.2 - 0.075 12.9 0.1 2.2 8.2 0.1 2.6 2 0 0 2 2 2 0 Lipase (class 3) Voldacs PF03517.13 AAS52770.2 - 3.3e-30 105.0 0.0 4.3e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Regulator of volume decrease after cellular swelling Orn_Arg_deC_N PF02784.16 AAS52771.2 - 1.8e-76 256.8 0.0 2.7e-76 256.2 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 AAS52771.2 - 1.2e-17 63.9 0.0 1.9e-17 63.3 0.0 1.4 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain AP_endonuc_2 PF01261.24 AAS52771.2 - 0.003 17.0 0.0 0.0068 15.9 0.0 1.6 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel GATA PF00320.27 AAS52772.2 - 1.4e-07 31.0 12.2 1.4e-07 31.0 12.2 1.9 2 0 0 2 2 2 1 GATA zinc finger Mtr2 PF10429.9 AAS52773.1 - 4.1e-75 251.2 0.0 4.6e-75 251.1 0.0 1.0 1 0 0 1 1 1 1 Nuclear pore RNA shuttling protein Mtr2 SnoaL_4 PF13577.6 AAS52773.1 - 0.019 15.1 0.0 0.027 14.6 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain SUR7 PF06687.12 AAS52774.1 - 2.6e-07 30.5 0.0 7.9e-07 28.9 0.0 1.8 1 1 0 1 1 1 1 SUR7/PalI family HCR PF07111.12 AAS52774.1 - 0.38 8.7 2.2 0.21 9.6 0.1 1.5 2 0 0 2 2 2 0 Alpha helical coiled-coil rod protein (HCR) DUF937 PF06078.11 AAS52774.1 - 3.3 8.3 9.3 51 4.5 0.0 3.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF937) Yip1 PF04893.17 AAS52774.1 - 4.8 6.9 16.0 0.79 9.4 9.4 2.3 2 0 0 2 2 2 0 Yip1 domain Fig1 PF12351.8 AAS52774.1 - 8.1 6.3 13.3 2.5 8.0 9.5 2.2 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 ABC_membrane_2 PF06472.15 AAS52775.1 - 5.3e-61 206.4 5.4 3.4e-40 138.2 0.2 2.3 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 ABC_tran PF00005.27 AAS52775.1 - 2.6e-16 60.4 0.0 5.5e-16 59.3 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AAS52775.1 - 8.2e-06 25.8 0.2 4.8e-05 23.3 0.1 2.3 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AAS52775.1 - 0.00025 21.6 1.1 0.0041 17.6 1.1 2.4 1 1 0 1 1 1 1 AAA domain Rad17 PF03215.15 AAS52775.1 - 0.0011 18.9 0.5 0.005 16.8 0.0 2.2 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_29 PF13555.6 AAS52775.1 - 0.028 14.1 0.0 0.067 12.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SMC_N PF02463.19 AAS52775.1 - 0.029 13.8 0.3 0.09 12.2 0.3 1.9 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Phage_holin_2_1 PF04971.12 AAS52775.1 - 0.058 13.4 0.4 2.1 8.4 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage P21 holin S RsgA_GTPase PF03193.16 AAS52775.1 - 0.079 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 AAS52775.1 - 0.13 12.6 0.0 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AAS52775.1 - 0.17 11.3 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Vps36_ESCRT-II PF11605.8 AAS52776.1 - 4.5e-30 103.7 0.1 9.1e-30 102.7 0.1 1.5 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 EAP30 PF04157.16 AAS52776.1 - 1.1e-16 60.8 0.8 1.5e-15 57.2 0.3 2.6 2 1 0 2 2 2 1 EAP30/Vps36 family Vps36-NZF-N PF16988.5 AAS52776.1 - 5.8e-14 51.2 2.0 5.8e-14 51.2 2.0 2.6 1 1 1 2 2 2 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 AAS52776.1 - 0.0056 16.7 9.9 0.029 14.4 4.8 2.4 2 0 0 2 2 2 1 Double zinc ribbon bPH_3 PF14470.6 AAS52776.1 - 0.0057 17.0 0.2 0.014 15.7 0.2 1.6 1 0 0 1 1 1 1 Bacterial PH domain zf-RanBP PF00641.18 AAS52776.1 - 0.0079 15.5 2.5 0.0079 15.5 2.5 2.7 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 AAS52776.1 - 0.01 15.8 10.0 0.15 12.1 0.2 2.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger GRAM PF02893.20 AAS52776.1 - 0.067 13.1 0.0 0.22 11.4 0.0 1.9 2 0 0 2 2 2 0 GRAM domain PH_TFIIH PF08567.11 AAS52776.1 - 0.068 13.5 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain Mo25 PF08569.11 AAS52777.1 - 7.6e-112 373.9 5.5 8.6e-112 373.7 5.5 1.0 1 0 0 1 1 1 1 Mo25-like Helicase_C PF00271.31 AAS52778.2 - 1.2e-16 61.0 0.0 4.9e-16 59.0 0.0 2.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AAS52778.2 - 4.1e-12 46.2 1.5 1e-11 44.9 1.5 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RWD PF05773.22 AAS52778.2 - 4.5e-12 46.3 0.1 1.5e-11 44.6 0.1 2.0 1 0 0 1 1 1 1 RWD domain OB_NTP_bind PF07717.16 AAS52778.2 - 1.8e-09 37.8 0.0 4.6e-09 36.5 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 AAS52778.2 - 2.2e-09 37.6 0.0 8.5e-09 35.7 0.0 2.1 1 0 0 1 1 1 1 Helicase associated domain (HA2) AAA_19 PF13245.6 AAS52778.2 - 2.8e-05 24.5 0.5 6.4e-05 23.3 0.5 1.5 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 AAS52778.2 - 0.002 17.8 0.0 0.0047 16.6 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain UBA PF00627.31 AAS52778.2 - 0.0031 17.4 0.2 0.017 15.0 0.1 2.1 2 0 0 2 2 2 1 UBA/TS-N domain PhoH PF02562.16 AAS52778.2 - 0.0075 15.7 0.2 0.021 14.3 0.0 1.8 2 0 0 2 2 2 1 PhoH-like protein ATPase PF06745.13 AAS52778.2 - 0.011 15.1 0.2 0.052 12.9 0.0 2.1 2 0 0 2 2 2 0 KaiC ResIII PF04851.15 AAS52778.2 - 0.013 15.5 0.4 0.035 14.1 0.4 1.7 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS52778.2 - 0.021 15.1 0.1 0.065 13.5 0.1 1.8 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AAS52778.2 - 0.023 13.8 0.1 0.044 12.8 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 AAS52778.2 - 0.027 14.2 0.1 0.049 13.3 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AAS52778.2 - 0.085 13.3 0.0 0.085 13.3 0.0 2.7 4 0 0 4 4 3 0 AAA domain Zot PF05707.12 AAS52778.2 - 0.1 12.2 0.1 0.29 10.8 0.1 1.7 1 1 0 1 1 1 0 Zonular occludens toxin (Zot) FtsK_SpoIIIE PF01580.18 AAS52778.2 - 0.14 11.5 0.0 0.35 10.2 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family CDC73_C PF05179.14 AAS52779.1 - 5.8e-51 172.3 2.9 1.1e-50 171.3 2.9 1.4 1 0 0 1 1 1 1 RNA pol II accessory factor, Cdc73 family, C-terminal EF-hand_1 PF00036.32 AAS52780.1 - 4.3e-26 88.5 11.5 3.3e-06 26.3 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 AAS52780.1 - 4.2e-22 78.4 6.4 2.8e-13 50.1 1.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS52780.1 - 2e-21 74.0 5.3 7.6e-05 22.3 0.2 4.3 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 AAS52780.1 - 4.7e-17 60.6 12.7 0.00022 20.6 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 AAS52780.1 - 1.4e-12 47.3 11.0 0.0055 16.5 0.1 4.3 4 0 0 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 AAS52780.1 - 7.2e-07 29.5 0.1 0.034 14.5 0.0 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 AAS52780.1 - 1.8e-06 27.9 9.8 0.0084 16.1 0.3 4.0 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 AAS52780.1 - 0.0039 17.5 0.2 1.9 8.9 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain Diphthamide_syn PF01866.17 AAS52781.1 - 2.2e-68 230.9 0.0 2.9e-68 230.5 0.0 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Amidohydro_2 PF04909.14 AAS52782.2 - 4.7e-08 33.2 0.1 1e-07 32.1 0.0 1.6 2 0 0 2 2 2 1 Amidohydrolase Amidohydro_1 PF01979.20 AAS52782.2 - 1.7e-05 24.3 0.1 3.6e-05 23.2 0.1 1.5 1 1 0 1 1 1 1 Amidohydrolase family RPN13_C PF16550.5 AAS52783.1 - 0.00088 19.4 0.0 0.0011 19.1 0.0 1.2 1 0 0 1 1 1 1 UCH-binding domain DUF3099 PF11298.8 AAS52783.1 - 0.043 13.9 0.0 0.088 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3099) Abdominal-A PF12407.8 AAS52783.1 - 0.5 10.0 6.4 1.6 8.4 6.4 1.9 1 0 0 1 1 1 0 Homeobox protein Proteasom_Rpn13 PF04683.13 AAS52784.1 - 3.2e-24 85.3 0.0 4.2e-24 84.9 0.0 1.2 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DUF3040 PF11239.8 AAS52784.1 - 0.077 13.3 0.2 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) CinA PF02464.17 AAS52785.1 - 5.2e-32 110.5 0.0 6.1e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 Competence-damaged protein DHR-2 PF06920.13 AAS52786.1 - 4.6e-39 134.5 0.0 7.6e-39 133.7 0.0 1.3 1 0 0 1 1 1 1 Dock homology region 2 DOCK_N PF16172.5 AAS52786.1 - 7.1e-10 38.3 0.2 1.4e-09 37.4 0.2 1.4 1 0 0 1 1 1 1 DOCK N-terminus ARTD15_N PF18084.1 AAS52786.1 - 0.11 12.8 0.3 9.8 6.5 0.0 3.4 4 0 0 4 4 4 0 ARTD15 N-terminal domain KKLCAg1 PF15204.6 AAS52786.1 - 0.12 12.5 0.1 0.48 10.6 0.1 2.0 1 0 0 1 1 1 0 Kita-kyushu lung cancer antigen 1 PP-binding PF00550.25 AAS52787.1 - 1.1e-10 41.7 0.1 1.4e-10 41.3 0.1 1.2 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 AAS52787.1 - 7.1e-07 29.4 1.1 8.8e-07 29.1 1.1 1.2 1 0 0 1 1 1 1 Acyl-carrier tRNA-synt_2c PF01411.19 AAS52787.1 - 0.076 11.5 0.0 0.084 11.4 0.0 1.0 1 0 0 1 1 1 0 tRNA synthetases class II (A) LRR_4 PF12799.7 AAS52788.1 - 5.3e-33 112.5 31.9 6.4e-07 29.6 0.7 6.7 3 1 3 6 6 6 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AAS52788.1 - 5.3e-28 96.6 25.5 1.5e-09 37.5 0.7 6.3 3 1 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 AAS52788.1 - 6e-17 61.7 17.0 8e-10 38.5 2.0 3.9 1 1 3 4 4 4 4 Leucine-rich repeat LRR_1 PF00560.33 AAS52788.1 - 5.7e-11 41.4 22.7 0.46 11.2 0.1 9.8 10 1 0 10 10 10 3 Leucine Rich Repeat LRR_6 PF13516.6 AAS52788.1 - 1.8e-06 27.6 16.9 0.2 11.8 0.3 7.9 9 0 0 9 9 9 2 Leucine Rich repeat LRR_2 PF07723.13 AAS52788.1 - 0.021 15.5 1.0 42 5.0 0.5 4.4 3 1 1 4 4 4 0 Leucine Rich Repeat YdiH PF15930.5 AAS52788.1 - 0.036 14.2 2.5 3.3 7.9 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function Poty_PP PF08440.10 AAS52788.1 - 0.91 8.6 4.9 0.67 9.0 0.3 2.2 2 0 0 2 2 2 0 Potyviridae polyprotein tRNA-synt_2b PF00587.25 AAS52789.1 - 2.6e-43 148.1 0.0 4.3e-43 147.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 AAS52789.1 - 1.4e-16 60.4 0.0 2.8e-16 59.4 0.0 1.5 1 0 0 1 1 1 1 Anticodon binding domain APG17 PF04108.12 AAS52790.1 - 1.4e-88 297.7 14.6 1.6e-88 297.5 14.6 1.0 1 0 0 1 1 1 1 Autophagy protein Apg17 Baculo_PEP_C PF04513.12 AAS52790.1 - 0.0054 16.8 5.3 2.9 7.9 0.1 4.1 4 0 0 4 4 4 1 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 AAS52790.1 - 0.022 14.1 4.6 0.063 12.6 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DASH_Duo1 PF08651.10 AAS52790.1 - 0.036 13.9 4.2 10 6.0 0.5 4.2 3 0 0 3 3 3 0 DASH complex subunit Duo1 FTO_CTD PF12934.7 AAS52790.1 - 0.059 13.1 0.9 0.42 10.3 0.1 2.5 2 1 0 2 2 2 0 FTO C-terminal domain Bacillus_HBL PF05791.11 AAS52790.1 - 0.078 12.8 0.4 0.078 12.8 0.4 3.2 2 2 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) YdiH PF15930.5 AAS52790.1 - 0.079 13.1 0.1 4 7.7 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function RhoGEF PF00621.20 AAS52790.1 - 0.34 11.1 8.8 1.4 9.1 2.2 3.1 1 1 0 2 2 2 0 RhoGEF domain HSBP1 PF06825.12 AAS52790.1 - 0.38 10.6 0.1 0.38 10.6 0.1 3.5 4 0 0 4 4 4 0 Heat shock factor binding protein 1 DUF3800 PF12686.7 AAS52790.1 - 3.1 8.4 5.4 68 4.1 5.0 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Fez1 PF06818.15 AAS52790.1 - 3.5 8.0 12.5 6.1 7.2 3.6 2.6 1 1 1 2 2 2 0 Fez1 G-patch PF01585.23 AAS52791.1 - 4.5e-15 55.3 5.1 8.3e-15 54.4 5.1 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 AAS52791.1 - 4.1e-09 36.4 1.2 9.1e-09 35.3 1.2 1.5 1 0 0 1 1 1 1 G-patch domain FUSC PF04632.12 AAS52791.1 - 0.09 11.3 0.7 0.17 10.4 0.7 1.4 1 0 0 1 1 1 0 Fusaric acid resistance protein family CHCH PF06747.13 AAS52792.1 - 4.3e-08 33.1 3.8 7.7e-08 32.3 3.8 1.4 1 0 0 1 1 1 1 CHCH domain GCK PF07802.11 AAS52792.1 - 3.1e-05 24.3 3.3 8.1e-05 23.0 3.3 1.7 1 0 0 1 1 1 1 GCK domain Synaptobrevin PF00957.21 AAS52793.1 - 3e-15 55.8 0.6 4.7e-15 55.1 0.6 1.3 1 0 0 1 1 1 1 Synaptobrevin Longin PF13774.6 AAS52793.1 - 3.7e-11 42.9 0.0 6.5e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain CNH PF00780.22 AAS52794.2 - 1.3e-18 67.6 0.5 4.2e-18 65.9 0.5 1.8 1 1 0 1 1 1 1 CNH domain RhoGEF PF00621.20 AAS52794.2 - 2.8e-09 37.5 0.0 6.5e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 RhoGEF domain PH_5 PF15405.6 AAS52794.2 - 6.1e-06 26.4 0.1 1.2e-05 25.4 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 AAS52794.2 - 0.13 12.0 0.4 15 5.4 0.0 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain adh_short PF00106.25 AAS52795.1 - 6.6e-27 94.2 0.0 8.9e-27 93.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS52795.1 - 8.7e-18 64.7 0.0 1.2e-17 64.3 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS52795.1 - 4.2e-08 33.3 0.2 4.7e-07 29.9 0.2 2.1 1 1 0 1 1 1 1 KR domain DAO PF01266.24 AAS52795.1 - 0.0029 17.2 0.0 0.0057 16.3 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Epimerase PF01370.21 AAS52795.1 - 0.015 14.8 0.1 0.028 13.9 0.1 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family SPC25 PF06703.11 AAS52796.1 - 2.5e-25 89.1 0.0 3e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) zf-C3HC4 PF00097.25 AAS52797.2 - 1.5e-06 28.0 0.3 3.5e-06 26.8 0.3 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS52797.2 - 2.3e-06 27.5 0.7 5.5e-06 26.3 0.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AAS52797.2 - 5.4e-05 23.1 2.2 0.00018 21.4 2.3 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AAS52797.2 - 0.00022 21.5 5.9 0.0003 21.1 4.4 2.0 1 1 1 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS52797.2 - 0.0012 18.7 2.4 0.0012 18.7 2.4 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS52797.2 - 0.0013 18.6 7.8 0.01 15.7 7.8 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AAS52797.2 - 0.0033 17.6 1.0 0.0033 17.6 1.0 1.8 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 AAS52797.2 - 0.37 10.7 14.1 0.42 10.5 7.2 2.9 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF1899 PF08953.11 AAS52798.1 - 7.7e-31 105.8 0.5 1.5e-30 104.8 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40_4 PF16300.5 AAS52798.1 - 3.8e-20 71.5 0.3 3.8e-20 71.5 0.3 1.9 2 0 0 2 2 2 1 Type of WD40 repeat WD40 PF00400.32 AAS52798.1 - 8e-17 61.3 2.8 0.0012 19.7 0.0 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 AAS52798.1 - 1.2e-06 27.6 0.1 0.00043 19.0 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AAS52798.1 - 0.00032 20.9 0.0 0.28 11.5 0.0 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS52798.1 - 0.021 13.8 0.0 0.9 8.4 0.0 2.3 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CLZ PF16526.5 AAS52798.1 - 0.076 13.4 1.6 0.17 12.3 1.6 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels BLOC1_2 PF10046.9 AAS52798.1 - 0.19 12.1 2.1 0.45 10.9 1.4 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF148 PF02520.17 AAS52798.1 - 0.42 10.7 3.0 0.75 9.9 3.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF148 Csm1_N PF18504.1 AAS52798.1 - 0.66 10.3 3.9 2.6 8.4 2.3 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain SEN1_N PF12726.7 AAS52799.2 - 6.3e-188 626.5 2.9 8.4e-188 626.1 2.9 1.2 1 0 0 1 1 1 1 SEN1 N terminal AAA_11 PF13086.6 AAS52799.2 - 4.6e-70 236.4 0.4 4.6e-70 236.4 0.4 2.2 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 AAS52799.2 - 5.9e-64 215.4 1.1 1.3e-62 211.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_30 PF13604.6 AAS52799.2 - 4.9e-09 36.2 0.0 0.0002 21.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AAS52799.2 - 5.9e-08 33.2 0.0 5.3e-07 30.1 0.0 2.4 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 AAS52799.2 - 3.7e-07 30.0 3.3 2.2e-05 24.1 0.1 3.3 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain Viral_helicase1 PF01443.18 AAS52799.2 - 7.4e-05 22.6 0.0 0.27 10.9 0.0 4.1 5 0 0 5 5 5 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 AAS52799.2 - 0.088 12.6 0.0 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 UvrD-like helicase C-terminal domain CHASE6_C PF17150.4 AAS52799.2 - 0.23 12.1 1.0 0.91 10.2 1.0 2.0 1 0 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain Borrelia_lipo_1 PF05714.11 AAS52800.1 - 0.011 15.5 0.0 0.4 10.4 0.0 2.2 2 0 0 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein SYCE1 PF15233.6 AAS52800.1 - 0.018 15.1 7.5 0.033 14.2 2.3 2.6 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 TBCA PF02970.16 AAS52800.1 - 0.32 11.4 6.0 0.22 11.9 1.5 2.8 2 0 0 2 2 2 0 Tubulin binding cofactor A FliD_N PF02465.18 AAS52800.1 - 1.3 9.7 4.0 0.72 10.6 0.9 2.2 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus IMPDH PF00478.25 AAS52801.2 - 6.9e-136 452.8 3.8 8e-136 452.6 3.8 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 AAS52801.2 - 8.9e-15 54.9 0.0 1.1e-06 29.0 0.0 2.6 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 AAS52801.2 - 3.7e-08 32.8 0.6 8e-08 31.7 0.6 1.6 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 AAS52801.2 - 3.6e-06 26.6 7.7 0.013 14.9 5.3 2.8 2 1 0 2 2 2 2 Nitronate monooxygenase His_biosynth PF00977.21 AAS52801.2 - 3e-05 23.6 1.9 0.0019 17.7 0.2 2.4 1 1 1 2 2 2 2 Histidine biosynthesis protein ThiG PF05690.14 AAS52801.2 - 0.0051 16.1 1.8 0.0082 15.5 0.5 2.0 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Aldolase PF01081.19 AAS52801.2 - 0.014 14.8 0.8 0.056 12.9 0.1 2.3 2 0 0 2 2 2 0 KDPG and KHG aldolase PcrB PF01884.17 AAS52801.2 - 0.019 14.5 2.2 1.7 8.1 0.0 3.2 3 1 0 4 4 4 0 PcrB family Metallophos PF00149.28 AAS52802.1 - 5.1e-36 125.1 0.0 8.2e-36 124.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FANCI_S3 PF14677.6 AAS52802.1 - 0.022 14.5 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 FANCI solenoid 3 WGG PF10273.9 AAS52803.1 - 4.5e-26 91.3 0.2 9.3e-26 90.3 0.2 1.5 1 0 0 1 1 1 1 Pre-rRNA-processing protein TSR2 DUF3245 PF11595.8 AAS52803.1 - 0.14 12.6 3.1 0.23 11.9 3.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) NOA36 PF06524.12 AAS52803.1 - 0.79 9.0 5.7 1.1 8.6 5.7 1.1 1 0 0 1 1 1 0 NOA36 protein Hid1 PF12722.7 AAS52804.2 - 7.3e-81 272.5 15.5 2.3e-54 184.8 0.7 2.9 3 1 0 3 3 3 2 High-temperature-induced dauer-formation protein Dymeclin PF09742.9 AAS52804.2 - 1.6e-29 102.9 6.0 5.4e-22 78.0 2.1 3.2 3 1 0 3 3 3 2 Dyggve-Melchior-Clausen syndrome protein RNR_inhib PF08591.10 AAS52805.1 - 1.5e-06 29.5 0.2 1.5e-05 26.3 0.0 2.1 1 1 1 2 2 2 1 Ribonucleotide reductase inhibitor Aminotran_3 PF00202.21 AAS52806.1 - 2.5e-119 398.6 0.0 2.8e-119 398.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 AAS52806.1 - 0.0019 17.5 0.0 0.0045 16.3 0.0 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase cNMP_binding PF00027.29 AAS52807.1 - 1.9e-25 88.7 0.0 3.3e-12 46.3 0.0 4.7 4 1 0 4 4 4 2 Cyclic nucleotide-binding domain Patatin PF01734.22 AAS52807.1 - 1.6e-19 70.9 1.8 3.9e-12 46.8 1.2 2.8 3 0 0 3 3 3 2 Patatin-like phospholipase LSM PF01423.22 AAS52808.1 - 3.7e-19 68.2 0.0 4.3e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 LSM domain DUF150_C PF17384.2 AAS52808.1 - 0.023 14.8 0.0 0.044 13.9 0.0 1.5 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Hfq PF17209.3 AAS52808.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 Hfq protein MRP-L47 PF06984.13 AAS52809.2 - 8.6e-25 86.7 0.6 1.8e-24 85.7 0.6 1.6 1 0 0 1 1 1 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) OGG_N PF07934.12 AAS52810.1 - 2.1e-23 82.7 0.1 4.1e-23 81.7 0.1 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.25 AAS52810.1 - 3e-15 56.6 0.0 5e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AAS52810.1 - 0.0029 17.4 0.0 0.0078 16.0 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif PIF1 PF05970.14 AAS52811.1 - 5.8e-73 246.2 0.7 4.2e-57 194.0 0.2 2.2 1 1 1 2 2 2 2 PIF1-like helicase AAA_30 PF13604.6 AAS52811.1 - 6.5e-21 74.9 0.0 1.2e-20 74.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AAS52811.1 - 1.6e-10 41.5 0.0 4.3e-10 40.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 AAS52811.1 - 3.3e-05 23.8 0.5 0.015 15.0 0.2 2.8 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 AAS52811.1 - 9.5e-05 22.7 0.2 0.00034 20.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 AAS52811.1 - 0.00036 20.3 0.0 0.016 15.0 0.0 2.7 2 0 0 2 2 2 1 UvrD-like helicase C-terminal domain Herpes_Helicase PF02689.14 AAS52811.1 - 0.00079 17.5 0.1 0.0055 14.7 0.0 1.9 2 0 0 2 2 2 1 Helicase NACHT PF05729.12 AAS52811.1 - 0.013 15.4 0.1 0.031 14.2 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 AAS52811.1 - 0.02 14.4 0.1 0.048 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region DEAD PF00270.29 AAS52811.1 - 0.023 14.5 0.2 3.4 7.4 0.0 2.4 2 0 0 2 2 2 0 DEAD/DEAH box helicase AAA PF00004.29 AAS52811.1 - 0.028 14.8 0.2 0.094 13.1 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Helicase_RecD PF05127.14 AAS52811.1 - 0.048 13.5 0.6 0.22 11.4 0.2 2.4 2 1 0 2 2 2 0 Helicase ATPase_2 PF01637.18 AAS52811.1 - 0.049 13.5 0.4 0.3 11.0 0.1 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea T2SSE PF00437.20 AAS52811.1 - 0.051 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.14 AAS52811.1 - 0.057 13.4 0.4 5.9 6.9 0.2 3.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF349 PF03993.12 AAS52811.1 - 0.059 13.7 1.0 0.22 11.8 0.0 2.5 2 1 0 2 2 2 0 Domain of Unknown Function (DUF349) AAA_16 PF13191.6 AAS52811.1 - 0.078 13.3 0.1 0.24 11.8 0.1 1.9 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 AAS52811.1 - 0.087 13.2 0.0 0.26 11.7 0.0 1.8 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 AAS52811.1 - 0.24 11.9 1.5 1.2 9.7 0.4 2.7 1 1 1 2 2 2 0 ABC transporter Sec39 PF08314.11 AAS52812.1 - 1.5e-82 278.3 1.2 8.4e-70 236.2 1.5 2.1 2 0 0 2 2 2 2 Secretory pathway protein Sec39 THOC7 PF05615.13 AAS52813.1 - 2.4e-06 27.9 6.6 2.4e-06 27.9 6.6 2.7 2 1 0 2 2 2 1 Tho complex subunit 7 Spc110_C PF18520.1 AAS52813.1 - 0.055 13.1 0.2 0.14 11.7 0.2 1.7 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain Ribosomal_S3Ae PF01015.18 AAS52814.1 - 1.5e-86 289.2 5.1 1.7e-86 289.0 5.1 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family DLP_helical PF18709.1 AAS52814.1 - 0.0071 15.6 0.6 0.011 14.9 0.6 1.3 1 0 0 1 1 1 1 Dynamin-like helical domain Abhydro_lipase PF04083.16 AAS52814.1 - 0.03 13.9 0.0 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Ras PF00071.22 AAS52815.1 - 2.1e-29 102.2 0.1 2.6e-29 101.9 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS52815.1 - 2e-21 76.4 0.0 1.2e-20 73.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS52815.1 - 5.9e-05 22.6 0.1 7.6e-05 22.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DLIC PF05783.11 AAS52815.1 - 0.00037 19.5 0.1 0.33 9.7 0.0 2.1 1 1 1 2 2 2 2 Dynein light intermediate chain (DLIC) Gtr1_RagA PF04670.12 AAS52815.1 - 0.0011 18.4 0.1 0.0013 18.1 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS52815.1 - 0.071 13.2 0.0 0.11 12.5 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 AAS52815.1 - 0.078 12.4 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_lid_10 PF17872.1 AAS52816.2 - 1.1e-33 115.3 0.1 3.1e-33 113.9 0.1 1.8 1 0 0 1 1 1 1 AAA lid domain AAA PF00004.29 AAS52816.2 - 3.4e-20 72.8 0.0 9.3e-20 71.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS52816.2 - 1.7e-08 35.0 0.0 2.5e-07 31.2 0.0 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS52816.2 - 6.3e-08 33.0 0.0 5.2e-07 30.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain BAH PF01426.18 AAS52816.2 - 2.8e-07 30.4 0.2 7.1e-07 29.1 0.2 1.7 1 0 0 1 1 1 1 BAH domain ATPase_2 PF01637.18 AAS52816.2 - 1.1e-05 25.4 0.1 1.1e-05 25.4 0.1 3.4 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_18 PF13238.6 AAS52816.2 - 0.0059 17.1 0.0 0.12 12.9 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 AAS52816.2 - 0.011 16.0 0.0 0.08 13.3 0.0 2.3 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AAS52816.2 - 0.038 13.9 0.0 0.081 12.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 AAS52816.2 - 0.081 13.0 0.1 0.4 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain Claudin_3 PF06653.11 AAS52817.2 - 0.13 12.2 7.6 0.048 13.6 4.8 1.6 2 0 0 2 2 2 0 Tight junction protein, Claudin-like GpcrRhopsn4 PF10192.9 AAS52818.1 - 0.028 13.8 7.3 0.064 12.7 1.3 3.0 3 0 0 3 3 3 0 Rhodopsin-like GPCR transmembrane domain COPIIcoated_ERV PF07970.12 AAS52819.1 - 3.6e-30 105.5 0.0 4.9e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 AAS52819.1 - 1.8e-22 79.4 0.0 3.7e-22 78.5 0.0 1.5 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF2660 PF10859.8 AAS52820.1 - 0.0094 16.4 0.3 0.017 15.6 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2660) DUF600 PF04634.12 AAS52820.1 - 0.01 15.9 0.5 0.013 15.5 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function, DUF600 SSrecog PF03531.14 AAS52821.1 - 1.6e-30 104.8 0.1 3.1e-28 97.5 0.0 3.3 3 0 0 3 3 3 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 AAS52821.1 - 1.8e-28 98.8 0.2 4e-26 91.3 0.1 2.7 2 0 0 2 2 2 1 POB3-like N-terminal PH domain Rtt106 PF08512.12 AAS52821.1 - 6.9e-27 93.7 0.0 2.8e-24 85.4 0.0 3.1 3 0 0 3 3 3 1 Histone chaperone Rttp106-like DUF4827 PF16109.5 AAS52821.1 - 0.018 15.0 0.5 0.049 13.6 0.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) DUF3780 PF12635.7 AAS52821.1 - 0.058 13.2 1.0 1.4 8.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3780) DUF4974 PF16344.5 AAS52821.1 - 0.61 10.1 6.0 21 5.2 0.4 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4974) Dak1 PF02733.17 AAS52822.2 - 1e-109 366.2 0.2 1.3e-109 365.8 0.2 1.1 1 0 0 1 1 1 1 Dak1 domain Dak2 PF02734.17 AAS52822.2 - 9.8e-49 165.6 0.8 1.6e-48 164.9 0.8 1.4 1 0 0 1 1 1 1 DAK2 domain SH3_9 PF14604.6 AAS52823.1 - 9.3e-14 51.0 0.1 1.6e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AAS52823.1 - 2.3e-13 49.5 0.1 4.4e-13 48.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS52823.1 - 1.4e-11 43.9 0.0 3.4e-11 42.7 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain CREPT PF16566.5 AAS52823.1 - 1.3 9.2 4.6 2.2 8.5 3.1 2.0 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Zn_clus PF00172.18 AAS52824.2 - 1.5e-07 31.4 7.3 3.4e-07 30.3 7.3 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain CoA_binding_2 PF13380.6 AAS52825.1 - 3.8e-21 75.7 0.0 4.5e-21 75.5 0.0 1.0 1 0 0 1 1 1 1 CoA binding domain Phage_connect_1 PF05135.13 AAS52825.1 - 0.22 12.0 0.0 0.3 11.6 0.0 1.2 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein Hexokinase_1 PF00349.21 AAS52826.1 - 2.8e-15 56.7 0.1 5.2e-15 55.9 0.1 1.3 1 0 0 1 1 1 1 Hexokinase Hexokinase_2 PF03727.16 AAS52826.1 - 4.9e-12 45.8 0.0 1.6e-06 27.8 0.0 2.5 1 1 1 2 2 2 2 Hexokinase StbA PF06406.11 AAS52826.1 - 0.02 14.2 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 StbA protein Cyt-b5 PF00173.28 AAS52827.1 - 3.8e-06 26.9 0.0 5.4e-06 26.5 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain cNMP_binding PF00027.29 AAS52828.1 - 3.5e-32 110.3 0.0 2.5e-16 59.5 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain F-box-like PF12937.7 AAS52828.1 - 7.5e-09 35.4 0.8 2.1e-08 33.9 0.8 1.9 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 AAS52828.1 - 3.8e-06 27.1 7.7 0.0043 17.4 1.1 5.2 4 1 1 5 5 5 2 Leucine Rich repeats (2 copies) F-box PF00646.33 AAS52828.1 - 7.8e-06 25.6 1.7 7.8e-06 25.6 1.7 2.9 4 0 0 4 4 4 1 F-box domain LRR_6 PF13516.6 AAS52828.1 - 3.5e-05 23.5 16.3 1.9 8.8 0.1 8.2 9 0 0 9 9 9 2 Leucine Rich repeat LRR_1 PF00560.33 AAS52828.1 - 0.00069 19.8 17.0 2.2 9.2 0.3 9.2 11 0 0 11 11 11 1 Leucine Rich Repeat LRR_8 PF13855.6 AAS52828.1 - 1.1 9.0 5.4 0.64 9.8 0.6 3.2 3 1 0 3 3 3 0 Leucine rich repeat vATP-synt_AC39 PF01992.16 AAS52829.2 - 2.2e-107 359.4 0.7 2.5e-107 359.3 0.7 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit BRCT_2 PF16589.5 AAS52829.2 - 0.011 16.2 0.1 0.27 11.7 0.1 2.4 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain OspD PF03207.13 AAS52829.2 - 0.09 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) Dor1 PF04124.12 AAS52830.2 - 9e-18 64.1 0.0 1.3e-16 60.2 0.0 2.5 1 1 0 1 1 1 1 Dor1-like family SCO1-SenC PF02630.14 AAS52830.2 - 0.089 12.7 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 SCO1/SenC C2 PF00168.30 AAS52831.1 - 2e-54 182.2 1.6 2.2e-19 69.6 0.0 6.3 6 0 0 6 6 6 5 C2 domain NT-C2 PF10358.9 AAS52831.1 - 0.00087 19.0 0.3 0.01 15.6 0.0 2.9 4 0 0 4 4 4 1 N-terminal C2 in EEIG1 and EHBP1 proteins Vfa1 PF08432.10 AAS52831.1 - 2.5 8.4 9.7 0.81 10.0 2.9 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Ribosomal_L6e PF01159.19 AAS52832.1 - 4.6e-39 133.4 1.4 6.2e-39 133.0 1.4 1.2 1 0 0 1 1 1 1 Ribosomal protein L6e FKBP_C PF00254.28 AAS52833.2 - 2.8e-28 98.1 1.3 6.1e-28 97.0 0.1 2.3 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 AAS52833.2 - 2.6e-23 82.6 4.6 2.6e-23 82.6 4.6 2.8 2 2 0 2 2 2 1 Nucleoplasmin-like domain Presenilin PF01080.17 AAS52833.2 - 0.18 10.5 17.9 0.25 10.1 6.9 2.1 2 0 0 2 2 2 0 Presenilin Coilin_N PF15862.5 AAS52833.2 - 0.73 9.6 42.4 0.46 10.3 24.3 2.3 2 0 0 2 2 2 0 Coilin N-terminus DUF4045 PF13254.6 AAS52833.2 - 0.73 9.4 22.6 1.9 8.0 10.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) GAGA_bind PF06217.12 AAS52833.2 - 4 7.6 20.3 12 6.1 0.6 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family DUF4228 PF14009.6 AAS52833.2 - 4.6 7.6 11.9 22 5.4 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) RR_TM4-6 PF06459.12 AAS52833.2 - 5.7 6.7 36.3 3.9 7.2 19.3 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2052 PF09747.9 AAS52833.2 - 8.8 6.4 40.1 4.2 7.4 12.0 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Neur_chan_memb PF02932.16 AAS52833.2 - 9.6 6.2 11.3 9.6 6.2 4.3 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region HMG-CoA_red PF00368.18 AAS52834.2 - 5.9e-141 469.7 0.4 7.8e-141 469.3 0.4 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase HPIH PF13323.6 AAS52834.2 - 2.1e-35 121.9 1.0 3.1e-35 121.3 0.1 1.8 2 0 0 2 2 2 1 N-terminal domain with HPIH motif Sterol-sensing PF12349.8 AAS52834.2 - 8.8e-08 32.1 6.1 8.8e-08 32.1 6.1 1.9 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation Zn_clus PF00172.18 AAS52835.1 - 2.2e-05 24.5 8.5 4.9e-05 23.3 8.5 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MCR PF18509.1 AAS52835.1 - 3.5 7.3 5.9 5.8 6.6 0.2 2.7 2 0 0 2 2 2 0 Magnetochrome domain Sybindin PF04099.12 AAS52836.1 - 1.8e-19 70.1 0.1 2.3e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 Sybindin-like family ENTH PF01417.20 AAS52837.1 - 3.3e-44 149.9 0.2 4.4e-44 149.5 0.2 1.2 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 AAS52837.1 - 0.0069 15.4 0.0 0.0092 15.0 0.0 1.2 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 AAS52837.1 - 0.022 14.6 0.1 0.033 14.0 0.1 1.3 1 0 0 1 1 1 0 VHS domain Pro_isomerase PF00160.21 AAS52838.1 - 6e-49 166.3 0.0 7.2e-49 166.1 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD TFR_dimer PF04253.15 AAS52839.1 - 3e-14 53.2 0.0 6e-14 52.2 0.0 1.5 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_M28 PF04389.17 AAS52839.1 - 7.3e-13 48.7 0.0 1.3e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M28 PA PF02225.22 AAS52839.1 - 2.6e-07 30.6 0.0 6e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 PA domain Dus PF01207.17 AAS52840.2 - 2.6e-82 276.4 0.0 3.3e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) PI_PP_I PF18363.1 AAS52840.2 - 0.054 13.7 0.0 0.13 12.5 0.0 1.6 1 0 0 1 1 1 0 Phosphoinositide phosphatase insertion domain zf-C2H2 PF00096.26 AAS52841.2 - 7.3e-08 32.5 11.1 6.8e-05 23.1 2.1 3.1 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS52841.2 - 1.4e-06 28.4 13.3 2.1e-05 24.7 4.9 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS52841.2 - 5.1e-05 23.8 11.0 0.0038 18.0 1.8 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-Di19 PF05605.12 AAS52841.2 - 0.53 10.6 4.3 1.8 8.9 4.3 1.9 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Methyltransf_16 PF10294.9 AAS52843.1 - 3.7e-18 65.9 0.0 6.1e-18 65.2 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 AAS52843.1 - 0.039 13.5 0.0 0.078 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Allantoicase PF03561.15 AAS52844.1 - 2.2e-88 293.6 0.0 4.6e-46 156.4 0.0 2.1 2 0 0 2 2 2 2 Allantoicase repeat ATP-synt_J PF04911.12 AAS52845.2 - 2e-27 94.5 1.1 2.3e-27 94.3 1.1 1.0 1 0 0 1 1 1 1 ATP synthase j chain Cys_Met_Meta_PP PF01053.20 AAS52846.2 - 7.4e-24 84.0 0.0 9.7e-23 80.3 0.0 2.1 2 0 0 2 2 2 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 AAS52846.2 - 0.028 13.6 0.0 0.051 12.7 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Glyco_hydro_47 PF01532.20 AAS52847.1 - 6e-140 467.2 0.5 6.9e-140 467.0 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ctf8 PF09696.10 AAS52848.1 - 1.1e-21 77.6 0.2 1.3e-19 70.9 0.2 2.1 1 1 0 1 1 1 1 Ctf8 zinc_ribbon_10 PF10058.9 AAS52849.1 - 4e-18 64.9 1.6 2.1e-17 62.6 0.8 2.2 2 0 0 2 2 2 1 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 AAS52849.1 - 0.0037 17.3 0.3 0.0057 16.7 0.3 1.3 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ALIX_LYPXL_bnd PF13949.6 AAS52849.1 - 0.0056 16.0 1.5 0.011 15.1 1.5 1.4 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV WXG100 PF06013.12 AAS52849.1 - 0.049 13.9 0.2 0.11 12.7 0.2 1.5 1 0 0 1 1 1 0 Proteins of 100 residues with WXG Zn_ribbon_SprT PF17283.2 AAS52849.1 - 0.067 13.1 1.2 0.067 13.1 1.2 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Seryl_tRNA_N PF02403.22 AAS52849.1 - 0.089 13.0 0.8 0.22 11.7 0.7 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Csm1_N PF18504.1 AAS52849.1 - 0.26 11.6 2.6 0.44 10.9 1.5 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain Com_YlbF PF06133.11 AAS52849.1 - 0.55 10.9 3.9 0.23 12.1 0.7 2.0 3 0 0 3 3 3 0 Control of competence regulator ComK, YlbF/YmcA NAC PF01849.18 AAS52850.1 - 6.9e-20 70.8 1.7 8.9e-20 70.4 0.6 1.8 2 0 0 2 2 2 1 NAC domain AAA PF00004.29 AAS52851.1 - 1e-50 171.6 0.0 1.5e-38 132.2 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS52851.1 - 4.4e-11 42.4 0.1 2.1e-10 40.2 0.1 2.2 1 1 0 1 1 1 1 AAA+ lid domain CDC48_2 PF02933.17 AAS52851.1 - 6.3e-11 41.9 1.8 1.6e-10 40.6 0.4 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 AAS52851.1 - 1.1e-09 38.7 0.2 0.00017 21.9 0.1 3.2 2 1 0 2 2 2 2 AAA domain AAA_16 PF13191.6 AAS52851.1 - 4.3e-09 37.0 0.3 0.0017 18.7 0.0 2.7 2 1 0 2 2 2 2 AAA ATPase domain CDC48_N PF02359.18 AAS52851.1 - 2.2e-07 31.0 0.0 1.4e-06 28.4 0.0 2.4 2 1 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain TIP49 PF06068.13 AAS52851.1 - 4.8e-07 29.3 1.3 0.014 14.6 0.1 2.8 2 1 1 3 3 3 2 TIP49 P-loop domain Mg_chelatase PF01078.21 AAS52851.1 - 1.3e-06 28.0 0.2 0.0022 17.4 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AAS52851.1 - 6e-06 26.3 0.0 0.0033 17.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 AAS52851.1 - 7.1e-06 26.2 0.0 0.06 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AAS52851.1 - 1.4e-05 25.0 4.0 0.035 14.0 0.2 3.8 4 1 0 5 5 3 2 NACHT domain RuvB_N PF05496.12 AAS52851.1 - 1.5e-05 24.8 0.1 0.087 12.6 0.1 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AAS52851.1 - 2.3e-05 24.6 0.0 0.0027 17.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) PhoH PF02562.16 AAS52851.1 - 2.8e-05 23.7 0.0 0.028 13.9 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein IstB_IS21 PF01695.17 AAS52851.1 - 2.9e-05 23.9 0.0 0.26 11.0 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_24 PF13479.6 AAS52851.1 - 8e-05 22.4 0.2 0.12 12.1 0.0 2.9 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 AAS52851.1 - 8.6e-05 22.5 0.0 0.79 9.7 0.0 2.9 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 AAS52851.1 - 0.00015 22.1 0.0 0.17 12.3 0.0 2.9 2 0 0 2 2 2 1 RNA helicase ABC_tran PF00005.27 AAS52851.1 - 0.00018 22.1 0.7 0.053 14.0 0.1 2.6 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 AAS52851.1 - 0.00024 21.6 0.0 0.4 11.2 0.0 2.9 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 AAS52851.1 - 0.00034 19.9 0.0 0.21 10.8 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain Sigma54_activat PF00158.26 AAS52851.1 - 0.00037 20.3 0.0 0.81 9.4 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF2075 PF09848.9 AAS52851.1 - 0.00037 19.8 0.1 0.51 9.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AAS52851.1 - 0.00056 19.7 0.0 0.98 9.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AAS52851.1 - 0.0007 19.2 0.0 0.1 12.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region ResIII PF04851.15 AAS52851.1 - 0.0023 18.0 0.0 1.7 8.6 0.0 2.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit TniB PF05621.11 AAS52851.1 - 0.0024 17.3 0.0 2.9 7.3 0.0 3.3 2 1 0 2 2 2 1 Bacterial TniB protein AAA_19 PF13245.6 AAS52851.1 - 0.0039 17.5 0.2 1.2 9.5 0.0 3.2 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 AAS52851.1 - 0.0044 17.0 0.5 4.9 7.0 0.0 3.6 2 2 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 AAS52851.1 - 0.0057 17.2 1.0 3.1 8.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 AAS52851.1 - 0.0061 15.9 0.2 0.3 10.4 0.0 2.4 2 0 0 2 2 2 1 KaiC Parvo_NS1 PF01057.17 AAS52851.1 - 0.0075 15.4 0.0 3.1 6.8 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 AAA_11 PF13086.6 AAS52851.1 - 0.0082 16.0 0.0 0.54 10.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 AAS52851.1 - 0.0091 15.6 0.5 5.1 6.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 AAS52851.1 - 0.019 14.0 0.0 2.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_17 PF13207.6 AAS52851.1 - 0.023 15.1 0.1 4.8 7.6 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AAS52851.1 - 0.024 14.9 0.0 4.2 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 AAS52851.1 - 0.039 13.7 0.1 1.8 8.2 0.1 2.4 2 0 0 2 2 2 0 Cytidylate kinase IPT PF01745.16 AAS52851.1 - 0.05 13.0 0.4 0.34 10.3 0.0 2.2 2 0 0 2 2 2 0 Isopentenyl transferase AAA_14 PF13173.6 AAS52851.1 - 0.057 13.5 0.1 3.8 7.6 0.0 2.8 3 0 0 3 3 2 0 AAA domain AAA_29 PF13555.6 AAS52851.1 - 0.059 13.1 0.2 4.7 7.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_3 PF07726.11 AAS52851.1 - 0.061 13.2 0.0 0.44 10.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AAS52851.1 - 0.083 12.8 0.0 14 5.6 0.0 2.8 2 1 0 2 2 2 0 Rad17 P-loop domain Bac_DnaA PF00308.18 AAS52851.1 - 0.1 12.4 0.0 17 5.2 0.0 2.6 2 0 0 2 2 2 0 Bacterial dnaA protein DEAD PF00270.29 AAS52851.1 - 0.1 12.3 0.1 23 4.7 0.0 3.5 3 1 1 4 4 4 0 DEAD/DEAH box helicase Vps4_C PF09336.10 AAS52851.1 - 0.1 12.6 0.0 0.27 11.3 0.0 1.7 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain Zeta_toxin PF06414.12 AAS52851.1 - 0.13 11.5 0.1 4.7 6.4 0.0 2.3 2 0 0 2 2 2 0 Zeta toxin Viral_helicase1 PF01443.18 AAS52851.1 - 0.15 11.8 0.0 0.95 9.1 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase cobW PF02492.19 AAS52851.1 - 0.51 9.9 1.8 35 3.9 0.1 3.3 3 0 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Yos9_DD PF17880.1 AAS52853.1 - 2.9e-13 50.1 0.0 4.6e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 Yos9 dimerzation domain PRKCSH PF07915.13 AAS52853.1 - 0.00076 20.4 0.1 0.0023 18.9 0.1 1.8 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Bromodomain PF00439.25 AAS52854.1 - 1.3e-16 60.4 0.8 5.1e-16 58.5 0.8 2.1 1 0 0 1 1 1 1 Bromodomain Bromo_TP PF07524.13 AAS52854.1 - 5.5e-07 29.5 0.1 5.1e-06 26.4 0.0 2.4 2 0 0 2 2 2 1 Bromodomain associated Bromo_TP_like PF17027.5 AAS52854.1 - 0.0037 17.4 0.1 0.016 15.3 0.1 2.2 1 0 0 1 1 1 1 Histone-fold protein UQ_con PF00179.26 AAS52855.1 - 2e-52 176.6 0.0 2.2e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AAS52855.1 - 0.0011 19.2 0.0 0.0017 18.7 0.0 1.3 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 AAS52855.1 - 0.005 16.5 0.0 0.0062 16.2 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AAS52855.1 - 0.019 14.9 0.0 0.029 14.2 0.0 1.3 1 0 0 1 1 1 0 UEV domain CBF PF03914.17 AAS52856.2 - 4.6e-46 157.0 0.6 4.6e-46 157.0 0.6 2.8 3 0 0 3 3 3 1 CBF/Mak21 family Cnd1 PF12717.7 AAS52856.2 - 0.052 13.6 0.6 0.11 12.5 0.6 1.5 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 NOC3p PF07540.11 AAS52856.2 - 0.09 13.2 0.2 0.28 11.7 0.0 2.0 2 0 0 2 2 2 0 Nucleolar complex-associated protein RNA_pol_Rpc4 PF05132.14 AAS52856.2 - 0.24 11.8 7.7 0.09 13.2 2.2 2.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 DDHD PF02862.17 AAS52856.2 - 1.1 9.3 3.9 8.3 6.5 1.4 2.4 2 0 0 2 2 2 0 DDHD domain Spore_coat_CotO PF14153.6 AAS52856.2 - 6.7 6.6 13.1 0.95 9.4 8.7 1.8 2 0 0 2 2 2 0 Spore coat protein CotO CCDC53 PF10152.9 AAS52856.2 - 7.7 6.9 9.1 24 5.3 5.4 2.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex TEA PF01285.18 AAS52858.2 - 2.4e-24 85.2 0.4 1.1e-23 83.1 0.4 2.3 1 0 0 1 1 1 1 TEA/ATTS domain Malectin PF11721.8 AAS52858.2 - 1.6 8.8 0.0 1.6 8.8 0.0 3.6 3 0 0 3 3 3 0 Malectin domain FTHFS PF01268.19 AAS52859.1 - 2.8e-250 831.3 1.4 3.8e-250 830.8 1.4 1.2 1 0 0 1 1 1 1 Formate--tetrahydrofolate ligase THF_DHG_CYH_C PF02882.19 AAS52859.1 - 4.8e-67 224.3 1.2 4.8e-67 224.3 1.2 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AAS52859.1 - 2.7e-37 127.6 1.2 1.2e-36 125.5 1.0 2.2 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AdoHcyase_NAD PF00670.21 AAS52859.1 - 0.12 12.4 0.7 3.7 7.6 0.7 2.5 1 1 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain CbiA PF01656.23 AAS52859.1 - 0.13 12.3 0.0 3.5 7.7 0.1 2.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Ribosomal_L19e PF01280.20 AAS52860.2 - 3.5e-59 199.0 10.7 3.5e-59 199.0 10.7 1.6 2 0 0 2 2 2 1 Ribosomal protein L19e DUF2423 PF10338.9 AAS52861.1 - 3.5e-18 65.5 6.1 3.5e-18 65.5 6.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2423) PBP1_TM PF14812.6 AAS52862.1 - 10 6.6 8.5 0.2 12.0 1.2 1.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zn_Tnp_IS1595 PF12760.7 AAS52863.1 - 0.0084 16.1 1.6 1.6 8.8 0.1 2.3 2 0 0 2 2 2 2 Transposase zinc-ribbon domain zinc_ribbon_15 PF17032.5 AAS52863.1 - 0.037 14.8 0.0 0.053 14.3 0.0 1.3 1 0 0 1 1 1 0 zinc-ribbon family DUF678 PF05077.12 AAS52863.1 - 0.076 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF678) PriA_CRR PF18319.1 AAS52863.1 - 0.2 11.7 2.5 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 PriA DNA helicase Cys-rich region (CRR) domain Fungal_trans PF04082.18 AAS52864.1 - 3.8e-15 55.7 0.2 9.2e-15 54.4 0.2 1.6 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS52864.1 - 6.3e-10 39.0 9.1 1.2e-09 38.1 9.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MnmE_helical PF12631.7 AAS52864.1 - 0.19 11.9 0.3 12 6.0 0.0 2.8 3 0 0 3 3 3 0 MnmE helical domain Mito_carr PF00153.27 AAS52865.1 - 1.8e-68 226.5 5.7 1.6e-24 85.6 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 AAS52865.1 - 0.036 13.3 0.0 0.34 10.1 0.0 2.0 2 0 0 2 2 2 0 Fuseless Msap1 PF17077.5 AAS52866.2 - 1.4e-26 93.5 25.2 3.7e-26 92.1 6.5 4.0 1 1 2 3 3 3 2 Mitotic spindle associated protein SHE1 Endonuclea_NS_2 PF13930.6 AAS52866.2 - 0.076 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 DNA/RNA non-specific endonuclease KH_1 PF00013.29 AAS52867.1 - 5.3e-37 125.5 3.6 1.1e-15 57.2 0.0 3.2 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 AAS52867.1 - 1.7e-08 34.2 2.5 0.086 12.7 0.2 3.3 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 AAS52867.1 - 0.0077 16.1 1.1 0.8 9.6 0.0 3.5 3 1 0 3 3 3 1 KH domain KH_5 PF13184.6 AAS52867.1 - 0.018 15.1 2.4 8 6.6 0.0 3.3 3 0 0 3 3 3 0 NusA-like KH domain HTH_23 PF13384.6 AAS52867.1 - 0.052 13.4 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HSP70 PF00012.20 AAS52868.2 - 9.9e-260 862.9 7.0 1.1e-259 862.7 7.0 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS52868.2 - 2.3e-17 62.8 0.0 3e-16 59.1 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AAS52868.2 - 0.00029 20.6 0.0 0.00093 19.0 0.0 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain DDR PF08841.10 AAS52868.2 - 0.031 13.3 0.3 0.76 8.7 0.1 2.2 2 0 0 2 2 2 0 Diol dehydratase reactivase ATPase-like domain BcrAD_BadFG PF01869.20 AAS52868.2 - 0.037 13.5 0.0 4.3 6.8 0.0 2.3 2 0 0 2 2 2 0 BadF/BadG/BcrA/BcrD ATPase family Hydantoinase_A PF01968.18 AAS52868.2 - 0.11 11.7 0.1 0.31 10.3 0.1 1.8 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase SWI-SNF_Ssr4 PF08549.10 AAS52868.2 - 0.54 8.8 6.5 0.4 9.3 0.1 2.1 2 0 0 2 2 2 0 Fungal domain of unknown function (DUF1750) Golgin_A5 PF09787.9 AAS52868.2 - 1.6 8.1 8.5 0.41 10.1 3.5 1.9 2 0 0 2 2 2 0 Golgin subfamily A member 5 PIP5K PF01504.18 AAS52869.2 - 6e-44 150.3 2.0 9.1e-35 120.2 0.7 3.9 2 1 1 3 3 3 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 AAS52869.2 - 1.2e-26 93.4 0.0 2.1e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family FYVE PF01363.21 AAS52869.2 - 1.3e-15 57.3 11.5 1.3e-15 57.3 11.5 2.9 3 0 0 3 3 3 1 FYVE zinc finger MbeD_MobD PF04899.12 AAS52869.2 - 0.033 14.3 1.2 0.39 10.9 0.1 3.0 2 0 0 2 2 2 0 MbeD/MobD like IBR PF01485.21 AAS52869.2 - 2.4 8.5 10.4 0.69 10.2 6.0 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Peptidase_M28 PF04389.17 AAS52870.2 - 8.1e-42 143.2 0.0 1.1e-41 142.8 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M28 ABC2_membrane PF01061.24 AAS52871.1 - 2.5e-35 121.8 19.1 2.5e-35 121.8 19.1 2.1 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 AAS52871.1 - 1.1e-26 94.0 0.0 1.7e-26 93.3 0.0 1.3 1 0 0 1 1 1 1 ABC transporter Laminin_EGF PF00053.24 AAS52871.1 - 0.01 15.9 7.5 0.01 15.9 7.5 4.2 2 2 1 3 3 3 0 Laminin EGF domain RsgA_GTPase PF03193.16 AAS52871.1 - 0.048 13.6 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase TMEMspv1-c74-12 PF11044.8 AAS52871.1 - 2.5 8.1 5.4 0.54 10.3 0.4 2.4 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein RNA_pol_Rpc34 PF05158.12 AAS52872.1 - 9.5e-117 390.1 0.4 1.1e-116 389.9 0.4 1.0 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit Rrf2 PF02082.20 AAS52872.1 - 0.045 14.1 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 Transcriptional regulator TrmB PF01978.19 AAS52872.1 - 0.092 12.6 0.5 0.75 9.7 0.3 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB RPA_C PF08784.11 AAS52872.1 - 0.12 13.1 0.1 0.54 10.9 0.1 2.1 2 0 0 2 2 2 0 Replication protein A C terminal B-block_TFIIIC PF04182.12 AAS52872.1 - 0.16 12.1 0.9 0.59 10.3 0.2 2.1 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC HTH_46 PF15977.5 AAS52872.1 - 0.17 11.9 2.5 0.91 9.6 0.1 2.9 3 0 0 3 3 3 0 Winged helix-turn-helix DNA binding Gpr1_Fun34_YaaH PF01184.19 AAS52873.2 - 1.3e-91 305.9 17.7 1.5e-91 305.7 17.7 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family BAR PF03114.18 AAS52874.1 - 1.9e-53 181.6 0.3 2.4e-53 181.2 0.3 1.1 1 0 0 1 1 1 1 BAR domain Jnk-SapK_ap_N PF09744.9 AAS52874.1 - 0.017 15.4 0.6 0.017 15.4 0.6 2.4 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 DUF2313 PF10076.9 AAS52874.1 - 0.052 13.4 0.3 0.14 12.1 0.0 1.9 3 0 0 3 3 3 0 Uncharacterised protein conserved in bacteria (DUF2313) NADH_4Fe-4S PF10589.9 AAS52874.1 - 0.061 13.4 0.1 0.18 11.9 0.1 1.8 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF2303 PF10065.9 AAS52874.1 - 0.11 11.7 0.1 0.13 11.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2303) DUF4164 PF13747.6 AAS52874.1 - 0.94 9.8 7.8 0.14 12.5 0.6 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) Sterol-sensing PF12349.8 AAS52875.1 - 1.2 8.9 12.5 0.025 14.4 2.0 3.1 3 0 0 3 3 3 0 Sterol-sensing domain of SREBP cleavage-activation EI24 PF07264.11 AAS52875.1 - 1.6 8.9 14.2 0.34 11.1 8.7 2.5 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) Pkinase PF00069.25 AAS52876.1 - 2.8e-49 167.9 0.0 4.4e-49 167.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52876.1 - 5.4e-26 91.4 0.0 7.1e-26 91.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52876.1 - 0.00062 19.2 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 AAS52876.1 - 0.014 15.3 0.2 0.1 12.5 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Kdo PF06293.14 AAS52876.1 - 0.088 12.2 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Fib_alpha PF08702.10 AAS52878.2 - 0.0082 16.3 1.6 0.01 16.0 0.5 1.7 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family ALIX_LYPXL_bnd PF13949.6 AAS52878.2 - 0.064 12.5 0.8 0.17 11.1 0.8 1.7 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV PAPS_reduct PF01507.19 AAS52879.1 - 1.5e-29 103.2 0.0 6.1e-29 101.3 0.0 1.8 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CHCH PF06747.13 AAS52880.1 - 4e-06 26.8 0.3 5.2e-06 26.4 0.3 1.2 1 0 0 1 1 1 1 CHCH domain Cmc1 PF08583.10 AAS52880.1 - 0.0033 17.4 0.4 0.0037 17.2 0.4 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 AAS52880.1 - 0.046 13.7 2.3 0.075 13.1 2.3 1.4 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Sdh5 PF03937.16 AAS52881.1 - 2.6e-27 94.6 0.6 4.1e-27 93.9 0.6 1.3 1 0 0 1 1 1 1 Flavinator of succinate dehydrogenase E1_DerP2_DerF2 PF02221.15 AAS52882.1 - 3.1e-30 105.3 0.0 3.9e-30 105.0 0.0 1.1 1 0 0 1 1 1 1 ML domain DUF4625 PF15418.6 AAS52882.1 - 0.021 15.1 0.0 0.034 14.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4625) Metallophos PF00149.28 AAS52883.1 - 6.5e-39 134.6 0.1 8.6e-39 134.2 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AAS52883.1 - 0.0017 18.7 0.2 0.0037 17.7 0.2 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 AAS52883.1 - 0.061 13.5 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 AAS52883.1 - 0.09 12.4 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain PCI PF01399.27 AAS52884.1 - 8.2e-17 61.6 0.0 3.7e-16 59.5 0.0 2.2 2 0 0 2 2 2 1 PCI domain Smg4_UPF3 PF03467.15 AAS52885.1 - 9.3e-31 107.2 22.9 2.4e-28 99.3 22.9 3.0 1 1 0 1 1 1 1 Smg-4/UPF3 family CDC45 PF02724.14 AAS52885.1 - 1.8 6.8 14.7 3.6 5.8 14.7 1.4 1 0 0 1 1 1 0 CDC45-like protein LSM PF01423.22 AAS52886.1 - 2.6e-20 71.9 0.0 5e-20 71.0 0.0 1.5 1 1 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AAS52886.1 - 0.0066 16.6 0.0 0.0096 16.0 0.0 1.4 1 1 0 1 1 1 1 Ataxin 2 SM domain PRP38 PF03371.15 AAS52887.1 - 1.4e-47 161.8 0.1 1.6e-47 161.6 0.1 1.0 1 0 0 1 1 1 1 PRP38 family Mitoc_mL59 PF18126.1 AAS52888.1 - 2.4e-30 105.5 3.5 2.4e-30 105.5 3.5 1.5 1 1 0 1 1 1 1 Mitochondrial ribosomal protein mL59 DER1 PF04511.15 AAS52890.1 - 0.019 14.9 6.8 0.029 14.3 6.8 1.3 1 0 0 1 1 1 0 Der1-like family Prefoldin PF02996.17 AAS52891.2 - 2.2e-31 108.3 0.7 3.2e-31 107.7 0.7 1.3 1 0 0 1 1 1 1 Prefoldin subunit Pox_A_type_inc PF04508.12 AAS52891.2 - 0.014 15.2 0.1 0.34 10.9 0.0 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat SOGA PF11365.8 AAS52891.2 - 0.028 15.6 2.1 2.3 9.4 0.3 2.3 2 0 0 2 2 2 0 Protein SOGA APOBEC_C PF05240.14 AAS52891.2 - 0.04 13.9 0.1 9.1 6.3 0.0 2.4 2 0 0 2 2 2 0 APOBEC-like C-terminal domain SNAD4 PF18750.1 AAS52891.2 - 0.072 13.2 0.1 0.52 10.4 0.0 2.1 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 IRF-2BP1_2 PF11261.8 AAS52892.2 - 0.013 15.0 0.2 0.033 13.8 0.2 1.6 1 0 0 1 1 1 0 Interferon regulatory factor 2-binding protein zinc finger CYSTM PF12734.7 AAS52893.1 - 0.0007 19.9 56.8 0.0022 18.3 29.8 4.8 2 2 0 2 2 2 1 Cysteine-rich TM module stress tolerance zf-C3HC4_2 PF13923.6 AAS52894.1 - 0.0016 18.2 0.5 0.0035 17.1 0.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS52894.1 - 0.0044 17.0 0.1 0.011 15.7 0.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AAS52894.1 - 0.0058 16.5 0.2 0.014 15.3 0.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS52894.1 - 0.012 15.6 0.7 0.012 15.6 0.7 1.8 2 0 0 2 2 2 0 zinc-RING finger domain Prok-RING_4 PF14447.6 AAS52894.1 - 0.028 14.3 0.1 0.069 13.0 0.1 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 AAS52894.1 - 0.037 13.9 0.3 0.037 13.9 0.3 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS52894.1 - 0.091 13.1 0.4 0.091 13.1 0.4 1.8 2 0 0 2 2 2 0 Ring finger domain Fer2_3 PF13085.6 AAS52894.1 - 0.1 12.6 0.1 0.23 11.5 0.1 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain zf-C3HC4_4 PF15227.6 AAS52894.1 - 2.2 8.5 5.8 0.28 11.4 0.5 2.0 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING Fibrillarin PF01269.17 AAS52895.1 - 3.2e-106 353.5 0.0 3.9e-106 353.2 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin GCD14 PF08704.10 AAS52895.1 - 2.2e-06 27.5 0.0 3.8e-06 26.8 0.0 1.3 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit FtsJ PF01728.19 AAS52895.1 - 0.01 16.0 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 AAS52895.1 - 0.041 13.6 0.0 0.068 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 AAS52895.1 - 0.056 13.1 0.0 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 16S rRNA methyltransferase RsmB/F Steroid_dh PF02544.16 AAS52896.1 - 9.4e-34 116.6 9.7 1.5e-33 115.9 9.7 1.3 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase Pkinase PF00069.25 AAS52897.1 - 1.6e-36 126.1 0.0 6.7e-16 58.4 0.0 3.8 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52897.1 - 4.3e-13 49.1 0.0 5.6e-08 32.4 0.0 3.1 3 0 0 3 3 3 2 Protein tyrosine kinase Orexin PF02072.15 AAS52897.1 - 0.042 13.8 0.0 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Prepro-orexin APH PF01636.23 AAS52897.1 - 0.052 13.5 0.0 0.27 11.1 0.0 2.1 1 1 1 2 2 2 0 Phosphotransferase enzyme family EMP24_GP25L PF01105.24 AAS52898.1 - 3.2e-21 76.1 0.0 3.7e-21 75.9 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3847 PF12958.7 AAS52898.1 - 0.17 12.0 1.4 0.29 11.3 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Amidohydro_1 PF01979.20 AAS52899.1 - 1.4e-30 106.8 0.0 9e-30 104.1 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AAS52899.1 - 2e-15 57.3 0.3 2.5e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family HEAT_EZ PF13513.6 AAS52900.2 - 1.1e-18 67.3 3.8 7.1e-12 45.6 0.0 8.1 8 1 0 8 8 8 1 HEAT-like repeat HEAT PF02985.22 AAS52900.2 - 2.7e-17 61.4 10.1 0.016 15.4 0.0 10.4 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 AAS52900.2 - 6.2e-14 52.1 0.2 0.00058 20.2 0.0 7.7 5 3 4 9 9 9 4 HEAT repeats Cnd1 PF12717.7 AAS52900.2 - 5.6e-09 36.3 1.7 0.012 15.6 0.0 4.2 4 0 0 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 AAS52900.2 - 8.8e-07 27.8 0.0 0.028 13.0 0.0 3.5 2 2 0 3 3 3 2 Adaptin N terminal region Vac14_Fab1_bd PF12755.7 AAS52900.2 - 3e-06 27.7 0.0 9.4 6.9 0.1 4.6 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 AAS52900.2 - 4.9e-05 22.6 7.2 0.94 8.5 0.1 5.6 4 1 1 5 5 5 2 RNAPII transcription regulator C-terminal DRIM PF07539.12 AAS52900.2 - 0.0036 15.7 0.0 0.32 9.3 0.1 2.8 2 1 1 3 3 3 1 Down-regulated in metastasis MMS19_N PF14500.6 AAS52900.2 - 0.026 14.1 1.1 25 4.3 0.0 4.3 4 2 1 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II RAI16-like PF10257.9 AAS52900.2 - 0.03 13.2 0.4 0.11 11.4 0.1 2.1 3 0 0 3 3 3 0 Retinoic acid induced 16-like protein SH3_1 PF00018.28 AAS52901.2 - 1.9e-09 36.9 0.0 5.1e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS52901.2 - 0.00025 20.8 0.0 0.00054 19.8 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SAICAR_synt PF01259.18 AAS52902.1 - 6.7e-104 347.0 0.0 7.8e-104 346.7 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase Pkinase PF00069.25 AAS52903.1 - 5.1e-56 190.0 0.0 6.8e-33 114.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52903.1 - 2.1e-31 109.1 0.0 3.7e-31 108.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS52903.1 - 0.0021 16.9 0.0 0.0037 16.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 AAS52903.1 - 0.063 13.2 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 AAS52904.1 - 3.3e-72 243.0 1.3 9.7e-72 241.5 0.2 2.3 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52904.1 - 2.9e-52 177.5 0.2 5.3e-52 176.7 0.2 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52904.1 - 6.4e-07 29.0 0.5 3.7e-05 23.2 0.0 2.4 1 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 AAS52904.1 - 0.0019 17.0 0.0 0.003 16.4 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 AAS52904.1 - 0.029 13.9 0.7 0.1 12.1 0.5 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Kdo PF06293.14 AAS52904.1 - 0.044 13.1 0.1 0.082 12.3 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS52904.1 - 0.068 13.1 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 AAS52904.1 - 0.07 12.7 2.1 0.15 11.7 0.1 2.3 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Carn_acyltransf PF00755.20 AAS52905.1 - 4.4e-195 649.7 0.0 5.1e-195 649.5 0.0 1.0 1 0 0 1 1 1 1 Choline/Carnitine o-acyltransferase Oxysterol_BP PF01237.18 AAS52906.2 - 2.6e-129 431.3 0.4 6.4e-129 430.0 0.0 1.9 2 0 0 2 2 2 1 Oxysterol-binding protein PH PF00169.29 AAS52906.2 - 2.7e-11 43.9 0.2 6.3e-11 42.7 0.2 1.7 1 0 0 1 1 1 1 PH domain Ank_5 PF13857.6 AAS52906.2 - 2.1e-10 40.6 0.1 1.5e-05 25.2 0.2 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AAS52906.2 - 3.6e-09 37.1 0.0 0.00013 22.4 0.0 2.8 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) PH_8 PF15409.6 AAS52906.2 - 7.8e-09 35.7 0.1 2.1e-08 34.4 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain Ank_4 PF13637.6 AAS52906.2 - 3.6e-08 33.8 0.1 0.00028 21.4 0.0 3.7 2 2 2 4 4 4 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 AAS52906.2 - 4.3e-08 32.8 0.0 0.0058 17.0 0.1 4.2 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 AAS52906.2 - 4.6e-06 26.8 0.1 0.00015 22.0 0.1 3.2 3 0 0 3 3 3 1 Ankyrin repeat PH_11 PF15413.6 AAS52906.2 - 0.00056 20.3 3.2 0.013 15.9 0.7 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain Phos_pyr_kin PF08543.12 AAS52907.2 - 4.7e-72 242.3 0.0 5.4e-72 242.1 0.0 1.0 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 AAS52907.2 - 0.00013 21.6 0.0 0.00017 21.2 0.0 1.4 1 1 0 1 1 1 1 Carbohydrate kinase PfkB PF00294.24 AAS52907.2 - 0.015 14.6 0.0 1.9 7.7 0.0 2.1 2 0 0 2 2 2 0 pfkB family carbohydrate kinase HK PF02110.15 AAS52907.2 - 0.73 9.2 5.3 1.7 7.9 1.1 2.6 2 1 0 2 2 2 0 Hydroxyethylthiazole kinase family zf-C2H2 PF00096.26 AAS52908.1 - 0.00077 19.8 3.2 0.023 15.1 0.3 2.9 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf_ZIC PF18366.1 AAS52908.1 - 0.091 12.9 0.8 0.25 11.5 0.1 2.0 2 0 0 2 2 2 0 Zic proteins zinc finger domain zf-C2H2_4 PF13894.6 AAS52908.1 - 0.13 13.2 5.9 2.9 9.0 0.1 3.3 3 0 0 3 3 3 0 C2H2-type zinc finger His_Phos_1 PF00300.22 AAS52909.1 - 7.3e-29 100.9 0.0 3.2e-14 53.1 0.0 3.1 2 1 1 3 3 3 3 Histidine phosphatase superfamily (branch 1) Transketolase_C PF02780.20 AAS52909.1 - 0.059 13.3 0.2 0.15 11.9 0.0 1.7 2 0 0 2 2 2 0 Transketolase, C-terminal domain Peptidase_M49 PF03571.15 AAS52910.1 - 9.5e-228 757.0 0.1 1.8e-227 756.1 0.0 1.4 2 0 0 2 2 2 1 Peptidase family M49 Arginosuc_synth PF00764.19 AAS52911.2 - 5.5e-161 536.2 0.0 6.3e-161 536.0 0.0 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase QueC PF06508.13 AAS52911.2 - 0.00017 21.2 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AAS52911.2 - 0.00056 18.8 0.0 0.00088 18.2 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase Asn_synthase PF00733.21 AAS52911.2 - 0.14 11.8 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase Pkinase PF00069.25 AAS52913.2 - 1.6e-63 214.5 0.0 2.7e-63 213.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52913.2 - 7.8e-31 107.3 0.0 1.4e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS52913.2 - 0.0071 15.3 0.1 0.0071 15.3 0.1 2.8 2 2 1 3 3 3 1 Haspin like kinase domain PAT1 PF09770.9 AAS52913.2 - 0.055 11.7 26.2 0.077 11.3 26.2 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Baculo_PP31 PF05311.11 AAS52913.2 - 0.28 10.6 6.3 0.44 10.0 6.3 1.2 1 0 0 1 1 1 0 Baculovirus 33KDa late protein (PP31) SPX PF03105.19 AAS52913.2 - 0.42 10.5 17.2 0.6 10.0 17.2 1.2 1 0 0 1 1 1 0 SPX domain TFIIA PF03153.13 AAS52913.2 - 0.56 10.2 29.0 0.77 9.7 29.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 AAS52913.2 - 0.81 10.7 0.0 0.81 10.7 0.0 2.3 2 0 0 2 2 2 0 WD domain, G-beta repeat Rtf2 PF04641.12 AAS52913.2 - 1.4 8.3 7.2 15 4.9 0.0 2.3 2 0 0 2 2 2 0 Rtf2 RING-finger PIF1 PF05970.14 AAS52914.1 - 3.3e-52 177.9 0.0 7.7e-50 170.1 0.0 2.4 1 1 0 1 1 1 1 PIF1-like helicase AAA_30 PF13604.6 AAS52914.1 - 5.4e-22 78.4 0.1 9.8e-22 77.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AAS52914.1 - 1.2e-07 32.2 0.0 2.2e-07 31.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AAS52914.1 - 6.5e-05 23.2 0.0 0.0005 20.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 AAS52914.1 - 0.00031 20.3 0.0 0.00084 18.9 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region Herpes_Helicase PF02689.14 AAS52914.1 - 0.00066 17.7 0.0 0.0097 13.9 0.0 2.2 2 0 0 2 2 2 1 Helicase AAA_16 PF13191.6 AAS52914.1 - 0.0017 18.8 0.4 0.01 16.2 0.1 2.3 1 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.29 AAS52914.1 - 0.0021 18.5 0.0 0.0046 17.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 AAS52914.1 - 0.0026 17.5 0.1 1.3 8.7 0.1 2.9 2 1 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 AAS52914.1 - 0.0089 15.8 0.2 0.033 14.0 0.2 2.1 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_5 PF07728.14 AAS52914.1 - 0.012 15.6 1.0 0.069 13.2 0.4 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TrwB_AAD_bind PF10412.9 AAS52914.1 - 0.026 13.5 0.1 0.042 12.8 0.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain SH3_13 PF18335.1 AAS52914.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF2075 PF09848.9 AAS52914.1 - 0.071 12.3 0.1 0.23 10.6 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AAS52914.1 - 0.11 11.5 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 AAS52914.1 - 0.12 12.3 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_14 PF13173.6 AAS52914.1 - 0.17 11.9 0.1 1.3 9.1 0.1 2.4 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 AAS52914.1 - 0.18 11.6 1.1 0.76 9.6 1.1 1.9 1 1 0 1 1 1 0 Helicase RNA_helicase PF00910.22 AAS52914.1 - 0.22 11.9 0.0 0.56 10.6 0.0 1.7 1 1 0 1 1 1 0 RNA helicase MatE PF01554.18 AAS52915.2 - 2.6e-63 212.5 31.4 4.7e-36 123.9 7.7 2.4 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 AAS52915.2 - 4.3e-05 23.6 12.2 0.00011 22.3 2.6 3.9 4 0 0 4 4 4 2 Polysaccharide biosynthesis C-terminal domain GCR1_C PF12550.8 AAS52916.1 - 1.3e-12 47.8 0.4 2.8e-12 46.8 0.4 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Ribosomal_L1 PF00687.21 AAS52917.2 - 1.5e-37 129.4 0.1 2.1e-37 128.8 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Elf1 PF05129.13 AAS52918.1 - 5.4e-30 103.3 1.9 7.4e-30 102.8 1.9 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like Ribosomal_L37ae PF01780.19 AAS52918.1 - 0.26 11.4 1.2 0.52 10.4 1.2 1.4 1 0 0 1 1 1 0 Ribosomal L37ae protein family zf-C2H2_2 PF12756.7 AAS52918.1 - 2.5 8.5 6.0 7.3 7.0 0.5 2.4 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Septin PF00735.18 AAS52919.1 - 4.8e-115 383.7 0.0 6.9e-115 383.2 0.0 1.2 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AAS52919.1 - 2.2e-06 27.7 0.0 4.4e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS52919.1 - 0.0001 22.3 2.0 0.00078 19.4 0.0 2.8 3 0 0 3 3 3 1 RsgA GTPase AAA_22 PF13401.6 AAS52919.1 - 0.00023 21.4 0.4 0.005 17.1 0.4 2.4 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AAS52919.1 - 0.0038 17.0 0.4 0.014 15.1 0.4 2.1 1 1 0 1 1 1 1 AAA domain Roc PF08477.13 AAS52919.1 - 0.0049 17.1 0.2 0.013 15.8 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AAS52919.1 - 0.006 17.0 0.0 0.025 14.9 0.0 2.0 1 1 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 AAS52919.1 - 0.0067 16.0 0.3 0.98 8.9 0.0 2.9 2 2 0 3 3 3 1 Elongation factor Tu GTP binding domain AIG1 PF04548.16 AAS52919.1 - 0.015 14.6 0.1 0.045 13.1 0.0 1.8 2 0 0 2 2 2 0 AIG1 family G-alpha PF00503.20 AAS52919.1 - 0.028 13.6 0.6 0.04 13.1 0.6 1.7 1 1 0 1 1 1 0 G-protein alpha subunit Dynamin_N PF00350.23 AAS52919.1 - 0.047 13.8 3.9 13 5.8 0.0 3.2 2 1 1 3 3 3 0 Dynamin family RNA_helicase PF00910.22 AAS52919.1 - 0.085 13.3 0.0 0.25 11.7 0.0 1.9 1 1 0 1 1 1 0 RNA helicase PGBA_C PF15437.6 AAS52919.1 - 0.86 10.0 6.5 2.5 8.5 6.5 1.9 1 1 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal Glycos_transf_3 PF00591.21 AAS52920.1 - 3.5e-78 262.7 0.0 4.9e-78 262.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 AAS52920.1 - 3.4e-11 42.8 0.0 6.1e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Methyltransf_16 PF10294.9 AAS52921.1 - 1.4e-20 73.8 0.0 2.2e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_31 PF13847.6 AAS52921.1 - 2e-07 30.9 0.0 2.9e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS52921.1 - 3.8e-07 30.1 0.0 6.4e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AAS52921.1 - 0.00015 21.5 0.0 0.00025 20.7 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 AAS52921.1 - 0.00021 22.0 0.0 0.00037 21.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AAS52921.1 - 0.00044 19.8 0.0 0.00078 19.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 AAS52921.1 - 0.0089 15.4 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DUF43 PF01861.16 AAS52921.1 - 0.014 14.6 0.0 0.019 14.2 0.0 1.2 1 0 0 1 1 1 0 Branched-chain polyamine synthase A C-terminal domain Methyltransf_12 PF08242.12 AAS52921.1 - 0.035 14.8 0.0 0.07 13.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 AAS52921.1 - 0.11 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TRM PF02005.16 AAS52921.1 - 0.19 10.9 0.0 0.25 10.4 0.0 1.2 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Spc110_C PF18520.1 AAS52922.1 - 7.7e-28 95.9 1.0 2.9e-27 94.0 1.0 2.1 1 0 0 1 1 1 1 Spindle pole body component 110 C-terminal domain DHR10 PF18595.1 AAS52922.1 - 1.1e-08 35.1 15.4 1.1e-08 35.1 15.4 9.6 3 3 4 8 8 8 2 Designed helical repeat protein 10 domain Spc7 PF08317.11 AAS52922.1 - 0.0018 17.2 13.4 0.0018 17.2 13.4 5.8 2 2 4 6 6 6 3 Spc7 kinetochore protein Nup54 PF13874.6 AAS52922.1 - 0.0095 16.0 4.5 0.0095 16.0 4.5 7.5 2 2 5 7 7 7 1 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 AAS52922.1 - 6 7.4 28.8 2.5 8.6 0.2 8.0 5 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 AAS52923.1 - 0.021 15.1 0.2 0.12 12.7 0.1 1.9 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 BORCS6 PF10157.9 AAS52923.1 - 0.041 14.1 0.1 0.049 13.9 0.1 1.3 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 DUF5617 PF18493.1 AAS52923.1 - 0.065 13.3 0.7 0.96 9.6 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5617) VHS PF00790.19 AAS52924.1 - 2.3e-46 157.1 0.1 9.9e-46 155.1 0.0 2.1 2 0 0 2 2 2 1 VHS domain Alpha_adaptinC2 PF02883.20 AAS52924.1 - 4.3e-22 78.5 0.0 7.8e-22 77.7 0.0 1.4 1 0 0 1 1 1 1 Adaptin C-terminal domain GAT PF03127.14 AAS52924.1 - 1.2e-21 76.8 1.6 4.2e-21 75.0 1.6 2.0 1 0 0 1 1 1 1 GAT domain GGA_N-GAT PF18308.1 AAS52924.1 - 2.1e-06 27.2 0.1 9.3e-06 25.2 0.1 2.2 1 0 0 1 1 1 1 GGA N-GAT domain DUF5344 PF17279.2 AAS52924.1 - 0.055 14.0 0.9 0.2 12.2 0.9 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5344) NMT1_3 PF16868.5 AAS52924.1 - 0.098 12.1 0.0 0.2 11.0 0.0 1.5 1 0 0 1 1 1 0 NMT1-like family Muted PF14942.6 AAS52924.1 - 0.26 11.6 4.0 0.48 10.8 4.0 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Fib_alpha PF08702.10 AAS52924.1 - 2.6 8.2 4.9 6.3 7.0 4.9 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HSA PF07529.13 AAS52925.2 - 4e-11 43.1 0.4 4e-11 43.1 0.4 2.7 2 0 0 2 2 2 1 HSA Myb_DNA-bind_6 PF13921.6 AAS52925.2 - 2.3e-09 37.4 0.2 9e-09 35.5 0.2 2.1 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 AAS52925.2 - 0.00091 19.4 0.0 0.0029 17.8 0.0 1.9 1 0 0 1 1 1 1 Myb-like DNA-binding domain BTB_3 PF16017.5 AAS52925.2 - 0.021 14.9 0.0 0.056 13.6 0.0 1.6 1 0 0 1 1 1 0 BTB/POZ domain BCIP PF13862.6 AAS52926.1 - 2e-46 158.4 0.1 2.6e-46 158.0 0.1 1.1 1 0 0 1 1 1 1 p21-C-terminal region-binding protein SET PF00856.28 AAS52927.1 - 0.087 13.2 0.0 0.17 12.3 0.0 1.5 1 0 0 1 1 1 0 SET domain EMP24_GP25L PF01105.24 AAS52928.1 - 2.4e-35 122.1 0.2 2.7e-35 121.9 0.2 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ThiF PF00899.21 AAS52929.1 - 3.3e-60 203.5 0.0 8.4e-60 202.1 0.0 1.6 2 1 0 2 2 2 1 ThiF family Rhodanese PF00581.20 AAS52929.1 - 1.3e-10 41.7 0.0 2.9e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain CENP-F_leu_zip PF10473.9 AAS52929.1 - 0.0017 18.4 0.1 0.0095 16.0 0.1 1.9 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Shikimate_DH PF01488.20 AAS52929.1 - 0.02 15.0 0.0 0.065 13.3 0.0 1.8 2 0 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase SYCE1 PF15233.6 AAS52929.1 - 0.087 12.9 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 HALZ PF02183.18 AAS52929.1 - 0.095 12.9 1.1 0.26 11.5 1.1 1.7 1 0 0 1 1 1 0 Homeobox associated leucine zipper AlaDh_PNT_C PF01262.21 AAS52929.1 - 0.23 10.7 0.6 0.52 9.6 0.1 1.8 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain WD40 PF00400.32 AAS52930.2 - 0.23 12.4 0.5 3.8 8.5 0.1 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat Cys_Met_Meta_PP PF01053.20 AAS52931.2 - 9.9e-64 215.2 0.0 2.4e-63 214.0 0.0 1.6 1 1 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 AAS52931.2 - 0.00066 18.7 0.0 0.001 18.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Aminotran_1_2 PF00155.21 AAS52931.2 - 0.0066 15.7 0.0 0.016 14.4 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II SelA PF03841.13 AAS52931.2 - 0.036 13.0 0.0 0.11 11.5 0.0 1.6 1 1 1 2 2 2 0 L-seryl-tRNA selenium transferase Rad60-SLD PF11976.8 AAS52932.1 - 7.5e-24 83.4 1.8 2.1e-23 82.0 0.5 2.2 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AAS52932.1 - 1.8e-06 27.6 0.1 4.7e-06 26.3 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin family TUG-UBL1 PF11470.8 AAS52932.1 - 0.18 12.1 0.3 7.5 6.9 0.0 2.4 2 0 0 2 2 2 0 TUG ubiquitin-like domain SR-25 PF10500.9 AAS52932.1 - 0.83 9.2 13.8 1.4 8.5 13.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein SPX PF03105.19 AAS52932.1 - 1.1 9.1 10.7 0.077 12.9 5.8 1.5 2 0 0 2 2 2 0 SPX domain RNA_pol_Rpb1_1 PF04997.12 AAS52933.2 - 1.6e-82 277.4 0.0 4.3e-82 276.0 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AAS52933.2 - 5.1e-81 272.0 0.1 7.4e-81 271.5 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AAS52933.2 - 1.1e-75 253.5 0.0 2.2e-75 252.5 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AAS52933.2 - 5.8e-39 133.6 0.0 2.1e-38 131.7 0.0 2.0 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AAS52933.2 - 4.6e-31 106.9 0.0 1.1e-30 105.7 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 DSS1_SEM1 PF05160.13 AAS52934.1 - 4.3e-20 71.5 11.7 4.8e-20 71.4 11.7 1.0 1 0 0 1 1 1 1 DSS1/SEM1 family AAA PF00004.29 AAS52935.2 - 4.5e-41 140.4 0.1 1.4e-40 138.8 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AAS52935.2 - 5.9e-19 67.8 0.1 1.3e-18 66.6 0.1 1.6 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_lid_3 PF17862.1 AAS52935.2 - 1.4e-07 31.2 0.0 3.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AAS52935.2 - 1.5e-05 25.4 0.1 0.016 15.6 0.0 2.6 1 1 1 2 2 2 2 AAA ATPase domain AAA_2 PF07724.14 AAS52935.2 - 2.3e-05 24.6 0.0 0.00024 21.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 AAS52935.2 - 6.8e-05 22.9 0.1 0.00039 20.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AAS52935.2 - 0.00083 19.1 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AAS52935.2 - 0.0017 18.6 1.4 0.084 13.1 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_33 PF13671.6 AAS52935.2 - 0.0063 16.7 0.0 0.027 14.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 AAS52935.2 - 0.008 15.7 0.1 0.054 12.9 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein ThylakoidFormat PF11264.8 AAS52935.2 - 0.011 15.4 1.4 0.023 14.4 1.4 1.4 1 0 0 1 1 1 0 Thylakoid formation protein Mg_chelatase PF01078.21 AAS52935.2 - 0.017 14.5 0.1 0.044 13.1 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 AAS52935.2 - 0.022 13.9 0.0 0.045 12.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 AAS52935.2 - 0.027 14.2 0.0 0.061 13.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 AAS52935.2 - 0.039 13.7 0.3 0.25 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain TolA_bind_tri PF16331.5 AAS52935.2 - 0.041 14.0 3.4 0.1 12.7 1.5 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation AAA_19 PF13245.6 AAS52935.2 - 0.053 13.9 0.5 0.18 12.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF1192 PF06698.11 AAS52935.2 - 0.09 12.8 1.4 0.22 11.6 1.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) AAA_24 PF13479.6 AAS52935.2 - 0.11 12.2 0.5 0.35 10.6 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 AAS52935.2 - 0.12 11.9 0.0 0.25 10.8 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region ATPase PF06745.13 AAS52935.2 - 0.18 11.1 1.4 0.33 10.3 0.0 2.1 3 0 0 3 3 3 0 KaiC WD40 PF00400.32 AAS52936.1 - 2.6e-26 91.4 4.7 7.8e-06 26.5 0.1 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52936.1 - 7.8e-10 38.9 0.0 0.091 13.1 0.0 4.9 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 AAS52936.1 - 0.017 14.1 0.0 0.071 12.0 0.0 1.9 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 AAS52936.1 - 0.02 13.9 0.0 0.044 12.8 0.0 1.6 1 1 0 1 1 1 0 Coatomer WD associated region BBS2_Mid PF14783.6 AAS52936.1 - 0.071 13.1 0.1 17 5.5 0.0 3.1 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 AAS52936.1 - 0.15 11.0 0.2 5.9 5.8 0.0 2.3 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Kei1 PF08552.11 AAS52937.1 - 1e-38 133.1 15.1 8.5e-38 130.1 15.1 1.9 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 RIO1 PF01163.22 AAS52938.1 - 5.5e-72 241.3 0.7 5.5e-72 241.3 0.7 2.3 3 0 0 3 3 3 1 RIO1 family CDC45 PF02724.14 AAS52938.1 - 0.15 10.3 18.7 0.22 9.8 18.7 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 AAS52938.1 - 1.5 8.9 23.9 2.9 7.9 23.9 1.5 1 0 0 1 1 1 0 YL1 nuclear protein DNA_pol_phi PF04931.13 AAS52938.1 - 1.5 6.8 21.5 2.4 6.1 21.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 AAS52938.1 - 6.6 5.1 10.5 12 4.3 10.5 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4724 PF15852.5 AAS52938.1 - 9.6 6.8 8.4 10 6.7 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4724) TLD PF07534.16 AAS52939.2 - 6e-26 91.3 0.0 2.1e-25 89.6 0.0 1.9 1 1 1 2 2 2 1 TLD NUC153 PF08159.12 AAS52940.2 - 3.1e-12 46.1 3.7 3.1e-12 46.1 3.7 3.0 3 0 0 3 3 3 1 NUC153 domain PH PF00169.29 AAS52942.2 - 8.3e-12 45.5 2.5 1.6e-05 25.4 0.6 2.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 AAS52942.2 - 0.00047 20.5 7.1 0.063 13.7 1.4 3.2 2 1 1 3 3 3 2 Pleckstrin homology domain Sorting_nexin PF03700.13 AAS52942.2 - 0.038 14.6 2.6 0.081 13.5 2.6 1.5 1 0 0 1 1 1 0 Sorting nexin, N-terminal domain PH_2 PF08458.10 AAS52942.2 - 0.12 12.7 0.5 1.5 9.2 0.0 2.5 2 1 0 2 2 2 0 Plant pleckstrin homology-like region Img2 PF05046.14 AAS52943.2 - 1.4e-18 67.0 0.2 1.8e-18 66.6 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) WD40 PF00400.32 AAS52944.1 - 1.1e-58 193.8 36.9 5.6e-10 39.6 0.3 9.0 8 1 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52944.1 - 3.8e-21 75.2 4.8 7.5e-06 26.2 0.1 5.1 4 1 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS52944.1 - 4.6e-09 36.4 0.5 5.6e-05 23.1 0.0 3.6 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A NLE PF08154.12 AAS52944.1 - 6.4e-08 33.0 0.0 1.1e-07 32.2 0.0 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain Ge1_WD40 PF16529.5 AAS52944.1 - 3.8e-06 26.1 0.9 0.16 10.9 0.6 4.0 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 AAS52944.1 - 5.6e-06 25.3 6.6 1.2 7.7 0.0 5.3 4 2 2 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 AAS52944.1 - 0.00086 18.2 0.2 0.31 9.7 0.0 3.1 2 1 0 3 3 3 1 Nup133 N terminal like Nbas_N PF15492.6 AAS52944.1 - 0.0073 15.7 1.7 0.52 9.6 0.1 3.1 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 AAS52944.1 - 0.01 15.2 0.0 3.5 6.9 0.0 3.3 4 0 0 4 4 4 0 WD40-like domain Cytochrom_D1 PF02239.16 AAS52944.1 - 0.01 14.4 0.1 0.19 10.2 0.1 2.5 2 1 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 AAS52944.1 - 0.043 13.8 0.1 3 7.9 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Pkinase PF00069.25 AAS52945.2 - 7.2e-66 222.3 0.0 1.2e-65 221.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS52945.2 - 3.4e-34 118.3 0.0 5.5e-34 117.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS52945.2 - 0.05 12.9 0.0 0.2 10.9 0.0 2.0 2 1 0 2 2 2 0 Kinase-like Kdo PF06293.14 AAS52945.2 - 0.055 12.8 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Metallophos PF00149.28 AAS52946.1 - 8.1e-35 121.2 0.1 1.3e-34 120.5 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AAS52946.1 - 0.068 13.4 0.0 0.096 12.9 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain ubiquitin PF00240.23 AAS52947.1 - 2.3e-05 24.1 0.1 2.7e-05 23.8 0.1 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AAS52947.1 - 0.00084 19.1 0.0 0.00092 19.0 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 AAS52947.1 - 0.032 14.9 0.1 0.036 14.8 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD Chorismate_bind PF00425.18 AAS52948.1 - 2e-63 214.3 0.0 3.7e-63 213.5 0.0 1.4 1 0 0 1 1 1 1 chorismate binding enzyme GATase PF00117.28 AAS52948.1 - 6.9e-32 110.7 0.0 1e-31 110.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Anth_synt_I_N PF04715.13 AAS52948.1 - 4.7e-13 49.5 0.0 1.1e-12 48.3 0.0 1.6 1 0 0 1 1 1 1 Anthranilate synthase component I, N terminal region Peptidase_C26 PF07722.13 AAS52948.1 - 5.5e-07 29.6 0.0 1.1e-06 28.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase C26 HTS PF04204.16 AAS52948.1 - 0.051 12.5 0.0 0.083 11.8 0.0 1.2 1 0 0 1 1 1 0 Homoserine O-succinyltransferase Glucosamine_iso PF01182.20 AAS52949.1 - 6.9e-55 186.4 0.0 2.6e-54 184.5 0.0 1.7 2 0 0 2 2 2 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase MAGE_N PF12440.8 AAS52949.1 - 0.058 14.1 1.8 0.1 13.3 1.8 1.4 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal PQ-loop PF04193.14 AAS52950.2 - 3.7e-22 77.9 6.4 1.2e-12 47.4 0.1 3.3 4 0 0 4 4 4 2 PQ loop repeat BCDHK_Adom3 PF10436.9 AAS52951.2 - 9.5e-54 181.6 0.0 1.3e-53 181.2 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 AAS52951.2 - 2.5e-11 44.0 0.0 6.2e-11 42.8 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AAS52951.2 - 0.0064 16.3 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3215 PF11503.8 AAS52952.1 - 2e-29 101.3 0.1 2.2e-29 101.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3215) PI31_Prot_C PF08577.11 AAS52953.2 - 3.3e-07 31.4 16.4 3.3e-07 31.4 16.4 2.0 2 0 0 2 2 2 1 PI31 proteasome regulator DUF2428 PF10350.9 AAS52954.2 - 2.7e-51 174.4 0.1 5.6e-51 173.4 0.1 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) HEAT PF02985.22 AAS52954.2 - 0.00055 20.0 3.8 0.22 11.9 0.0 5.7 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 AAS52954.2 - 0.00093 19.5 0.4 2.4 8.6 0.0 4.4 4 1 1 5 5 5 1 HEAT repeats TAF6_C PF07571.13 AAS52954.2 - 0.057 13.7 0.1 17 5.8 0.0 3.0 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain DUF1548 PF07579.11 AAS52954.2 - 0.12 12.7 1.3 23 5.3 0.3 2.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) Herpes_ori_bp PF02399.15 AAS52954.2 - 0.2 9.7 2.5 0.85 7.6 0.1 2.6 3 0 0 3 3 3 0 Origin of replication binding protein Mg_trans_NIPA PF05653.14 AAS52955.1 - 1.1e-108 362.9 16.3 1.3e-108 362.6 16.3 1.0 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 AAS52955.1 - 3.5e-05 24.0 33.5 8.1e-05 22.8 8.5 3.8 3 1 0 3 3 3 2 EamA-like transporter family Acyl_transf_3 PF01757.22 AAS52955.1 - 0.00078 18.6 10.5 0.018 14.1 3.4 2.2 1 1 1 2 2 2 2 Acyltransferase family DUF4131 PF13567.6 AAS52955.1 - 0.012 15.2 0.1 2.8 7.5 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) MerT PF02411.15 AAS52955.1 - 0.045 13.8 0.7 0.045 13.8 0.7 2.9 2 1 0 2 2 2 0 MerT mercuric transport protein DUF202 PF02656.15 AAS52955.1 - 0.38 11.2 15.6 2.9 8.4 0.0 4.4 3 2 1 4 4 4 0 Domain of unknown function (DUF202) Phage_holin_1 PF04531.13 AAS52955.1 - 1.5 9.4 6.1 20 5.8 0.8 3.1 2 1 0 2 2 2 0 Bacteriophage holin eIF-1a PF01176.19 AAS52956.1 - 1.5e-20 72.8 0.1 2.1e-20 72.3 0.1 1.3 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Glyco_transf_20 PF00982.21 AAS52957.1 - 1.8e-160 534.8 0.4 8.6e-160 532.5 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AAS52957.1 - 2.2e-34 118.6 0.0 5.9e-34 117.2 0.0 1.7 2 0 0 2 2 2 1 Trehalose-phosphatase Tautomerase_2 PF14552.6 AAS52957.1 - 0.12 12.5 0.2 0.52 10.5 0.1 2.1 2 0 0 2 2 2 0 Tautomerase enzyme TatD_DNase PF01026.21 AAS52958.2 - 3.2e-32 111.9 0.0 4.5e-32 111.4 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase TPR_10 PF13374.6 AAS52958.2 - 0.082 12.8 0.0 3.1 7.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat SAP30_Sin3_bdg PF13867.6 AAS52959.2 - 7e-13 48.7 0.2 7.4e-09 35.8 0.0 2.4 2 0 0 2 2 2 2 Sin3 binding region of histone deacetylase complex subunit SAP30 Cue1_U7BR PF18499.1 AAS52960.1 - 4.8e-19 68.1 1.8 7.5e-19 67.5 1.8 1.3 1 0 0 1 1 1 1 Ubc7p-binding region of Cue1 CUE PF02845.16 AAS52960.1 - 9.1e-12 44.4 0.0 1.9e-11 43.4 0.0 1.6 2 0 0 2 2 2 1 CUE domain WD40 PF00400.32 AAS52961.1 - 5.7e-19 68.1 13.4 0.00076 20.3 0.0 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS52961.1 - 4e-14 52.7 0.1 0.00023 21.4 0.0 4.6 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS52961.1 - 2.4e-05 24.3 0.2 0.0071 16.2 0.1 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 AAS52961.1 - 0.0013 17.9 0.6 0.086 11.9 0.2 2.3 2 1 0 2 2 2 2 Coatomer WD associated region Ge1_WD40 PF16529.5 AAS52961.1 - 0.11 11.4 0.1 3.6 6.5 0.0 2.6 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HAD_SAK_1 PF10307.9 AAS52962.1 - 7.4e-56 189.2 0.0 1.1e-55 188.6 0.0 1.3 1 0 0 1 1 1 1 HAD domain family 1 in Swiss Army Knife RNA repair proteins RSN1_7TM PF02714.15 AAS52963.2 - 4.3e-71 239.4 22.1 4.3e-71 239.4 22.1 1.8 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AAS52963.2 - 5.7e-34 117.1 0.3 5.7e-34 117.1 0.3 2.5 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AAS52963.2 - 4.5e-30 105.2 0.1 7e-30 104.5 0.1 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PHM7_ext PF12621.8 AAS52963.2 - 1.6e-25 89.1 0.1 3.2e-25 88.1 0.1 1.5 1 0 0 1 1 1 1 Extracellular tail, of 10TM putative phosphate transporter Pyrophosphatase PF00719.19 AAS52964.1 - 3.3e-51 173.3 0.0 4.7e-51 172.8 0.0 1.2 1 0 0 1 1 1 1 Inorganic pyrophosphatase Nup188 PF10487.9 AAS52965.2 - 4.9e-303 1007.7 23.3 1e-302 1006.6 23.3 1.5 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 Nup188_C PF18378.1 AAS52965.2 - 4.5e-24 85.0 7.7 9.6e-24 83.9 7.7 1.5 1 0 0 1 1 1 1 Nuclear pore protein NUP188 C-terminal domain RRM_occluded PF16842.5 AAS52966.1 - 2.6e-31 107.3 0.2 2.5e-24 84.9 0.0 4.5 4 1 0 4 4 4 2 Occluded RNA-recognition motif RRM_1 PF00076.22 AAS52966.1 - 2.2e-29 101.1 0.0 3.3e-09 36.5 0.0 3.5 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 AAS52966.1 - 0.0086 16.3 0.0 7.5 6.8 0.0 3.3 3 0 0 3 3 3 1 Cytosolic domain of 10TM putative phosphate transporter Lsm_interact PF05391.11 AAS52966.1 - 0.024 14.1 1.1 0.054 13.0 1.1 1.5 1 0 0 1 1 1 0 Lsm interaction motif RRM_5 PF13893.6 AAS52966.1 - 0.059 13.0 0.0 3.6 7.2 0.0 3.1 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AAS52966.1 - 0.074 13.1 0.5 17 5.5 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif G-patch PF01585.23 AAS52967.1 - 0.018 14.9 2.5 0.078 12.9 2.5 2.1 1 1 0 1 1 1 0 G-patch domain Neur_chan_memb PF02932.16 AAS52967.1 - 0.38 10.8 1.9 0.33 11.0 1.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SAPS PF04499.15 AAS52967.1 - 0.56 8.9 7.8 0.65 8.7 7.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 AAS52967.1 - 1.3 8.8 15.1 1.8 8.3 15.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PXA PF02194.15 AAS52968.1 - 1.3e-35 123.0 0.3 1.3e-35 123.0 0.3 2.9 3 0 0 3 3 3 1 PXA domain Nexin_C PF08628.12 AAS52968.1 - 3.5e-22 79.1 1.0 3.5e-22 79.1 1.0 2.2 2 0 0 2 2 2 1 Sorting nexin C terminal PX PF00787.24 AAS52968.1 - 7.6e-13 48.4 1.1 7.6e-13 48.4 1.1 2.7 3 0 0 3 3 3 1 PX domain RGS PF00615.19 AAS52968.1 - 1.2e-07 32.0 1.6 5.4e-07 29.9 1.6 2.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DndE PF08870.11 AAS52968.1 - 0.042 14.1 0.0 0.13 12.6 0.0 1.8 1 0 0 1 1 1 0 DNA sulphur modification protein DndE RRN9 PF10680.9 AAS52969.1 - 6.8e-16 58.3 1.2 1.8e-15 56.9 1.2 1.8 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor SRP19 PF01922.17 AAS52970.1 - 3.9e-30 104.7 0.0 6.1e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 SRP19 protein Pribosyltran PF00156.27 AAS52971.1 - 7.8e-18 64.5 0.3 1.1e-17 64.0 0.3 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain MctB PF11382.8 AAS52971.1 - 0.023 14.4 0.1 0.03 14.0 0.1 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB zf-HC2 PF13490.6 AAS52971.1 - 0.18 12.1 0.1 0.3 11.4 0.1 1.3 1 0 0 1 1 1 0 Putative zinc-finger Fungal_trans PF04082.18 AAS52972.2 - 1.6e-22 79.9 0.5 2.7e-22 79.1 0.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS52972.2 - 3.9e-07 30.1 12.1 7.6e-07 29.2 12.1 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain FMO-like PF00743.19 AAS52973.1 - 9.4e-41 139.8 0.0 7e-35 120.4 0.0 2.8 3 0 0 3 3 3 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 AAS52973.1 - 3.6e-21 75.7 0.0 7.4e-18 64.8 0.0 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AAS52973.1 - 1.9e-15 56.8 0.0 4.3e-14 52.4 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AAS52973.1 - 5.6e-15 55.7 0.1 7.4e-07 29.3 0.0 3.9 4 0 0 4 4 4 2 FAD-NAD(P)-binding DAO PF01266.24 AAS52973.1 - 2.7e-10 40.4 1.7 0.00048 19.8 0.2 2.7 2 1 0 3 3 3 2 FAD dependent oxidoreductase Thi4 PF01946.17 AAS52973.1 - 1.4e-09 37.6 0.4 3.6e-06 26.4 0.0 2.2 2 0 0 2 2 2 2 Thi4 family NAD_binding_8 PF13450.6 AAS52973.1 - 5.6e-09 36.1 0.0 1.4e-08 34.9 0.0 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain K_oxygenase PF13434.6 AAS52973.1 - 5.1e-07 29.2 0.0 0.0011 18.2 0.0 3.0 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 AAS52973.1 - 2e-06 28.3 0.3 0.0018 18.8 0.0 2.7 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AAS52973.1 - 2.8e-06 26.3 2.6 0.00017 20.4 0.4 2.6 2 1 0 2 2 2 1 HI0933-like protein Amino_oxidase PF01593.24 AAS52973.1 - 6.9e-06 25.6 0.0 0.0053 16.1 0.0 2.4 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 AAS52973.1 - 4.9e-05 22.6 0.0 0.0013 17.8 0.0 2.2 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 AAS52973.1 - 0.0012 18.1 0.3 0.0039 16.5 0.0 1.9 3 0 0 3 3 3 1 FAD binding domain Malic_M PF03949.15 AAS52973.1 - 0.0013 18.0 0.3 0.08 12.2 0.0 2.5 3 0 0 3 3 3 1 Malic enzyme, NAD binding domain FAD_binding_2 PF00890.24 AAS52973.1 - 0.0017 17.6 0.1 0.0028 16.8 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 AAS52973.1 - 0.0017 18.4 0.0 0.51 10.4 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AAS52973.1 - 0.0027 18.1 0.0 0.5 10.8 0.0 2.3 2 0 0 2 2 2 1 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AAS52973.1 - 0.003 16.9 0.0 2.6 7.4 0.0 2.2 2 0 0 2 2 2 2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glu_dehyd_C PF16912.5 AAS52973.1 - 0.019 14.4 0.0 5.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Glucose dehydrogenase C-terminus IlvN PF07991.12 AAS52973.1 - 0.033 13.8 0.9 7.8 6.0 0.0 2.7 2 1 0 3 3 3 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain FAD_oxidored PF12831.7 AAS52973.1 - 0.11 11.9 0.1 0.11 11.9 0.1 1.5 2 0 0 2 2 1 0 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 AAS52973.1 - 0.14 11.4 1.1 0.49 9.7 0.3 2.0 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain GIDA PF01134.22 AAS52973.1 - 1.9 7.5 5.8 0.91 8.5 0.2 2.6 3 0 0 3 3 3 0 Glucose inhibited division protein A Trp_halogenase PF04820.14 AAS52973.1 - 3.3 6.5 4.5 0.51 9.1 0.5 1.6 2 0 0 2 2 2 0 Tryptophan halogenase Ctr PF04145.15 AAS52974.1 - 2.4e-19 70.4 11.7 7.1e-13 49.4 4.0 2.1 1 1 1 2 2 2 2 Ctr copper transporter family 7TM_GPCR_Srv PF10323.9 AAS52974.1 - 0.0011 18.4 0.4 0.0013 18.1 0.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srv DUF898 PF05987.13 AAS52974.1 - 0.01 15.0 1.4 0.012 14.7 1.4 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) DUF1286 PF06939.11 AAS52974.1 - 0.058 13.7 1.9 0.058 13.7 1.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1286) Enolase_C PF00113.22 AAS52975.1 - 1.9e-152 506.6 0.1 2.5e-152 506.2 0.1 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AAS52975.1 - 5.8e-59 198.0 0.4 1.1e-58 197.1 0.4 1.5 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AAS52975.1 - 1.6e-06 27.9 0.0 2.9e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 AAS52975.1 - 0.055 12.6 1.1 0.087 12.0 0.2 1.8 2 1 0 2 2 2 0 Methylaspartate ammonia-lyase C-terminus GCP_N_terminal PF17681.1 AAS52976.1 - 1.3e-44 153.1 0.1 3e-44 151.9 0.1 1.6 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 AAS52976.1 - 2.9e-24 86.1 0.4 6.1e-24 85.0 0.4 1.5 1 1 0 1 1 1 1 Gamma tubulin complex component C-terminal Proteasome PF00227.26 AAS52977.1 - 1e-53 181.7 0.1 1.3e-53 181.3 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS52977.1 - 2.9e-12 46.0 0.0 5.3e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Bromodomain PF00439.25 AAS52978.1 - 6.9e-26 90.1 1.7 1.4e-25 89.1 1.7 1.6 1 0 0 1 1 1 1 Bromodomain Acetyltransf_1 PF00583.25 AAS52978.1 - 2.4e-09 37.4 0.1 4.6e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AAS52978.1 - 7.7e-06 25.9 0.0 1.5e-05 24.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AAS52978.1 - 0.00055 20.3 0.2 0.001 19.4 0.2 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain ThiF PF00899.21 AAS52979.1 - 8.6e-48 162.8 0.0 1.3e-47 162.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family ATG7_N PF16420.5 AAS52979.1 - 4.2e-47 161.2 0.4 1.7e-46 159.3 0.4 1.9 1 1 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Shikimate_DH PF01488.20 AAS52979.1 - 0.00059 19.9 0.0 0.017 15.2 0.0 2.3 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 AAS52979.1 - 0.0092 15.6 0.0 0.019 14.6 0.0 1.5 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA LpxB PF02684.15 AAS52979.1 - 0.045 12.6 0.0 0.075 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipid-A-disaccharide synthetase 2-Hacid_dh_C PF02826.19 AAS52979.1 - 0.067 12.5 0.0 3.3 7.0 0.0 2.3 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NMD3 PF04981.13 AAS52980.2 - 9.3e-85 284.0 2.2 1.7e-84 283.1 2.2 1.4 1 0 0 1 1 1 1 NMD3 family HypA PF01155.19 AAS52980.2 - 0.33 11.0 6.7 5.3 7.1 0.1 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AAS52980.2 - 2.4 8.3 7.5 37 4.5 7.7 2.5 1 1 0 1 1 1 0 Double zinc ribbon FYVE PF01363.21 AAS52980.2 - 4.8 7.4 6.4 0.82 9.8 0.2 2.6 3 0 0 3 3 3 0 FYVE zinc finger NOP19 PF10863.8 AAS52981.1 - 2.1e-50 170.2 5.5 3e-50 169.7 5.5 1.2 1 0 0 1 1 1 1 Nucleolar protein 19 DEAD PF00270.29 AAS52982.1 - 5e-41 140.4 0.2 1.4e-40 138.9 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS52982.1 - 4e-32 110.9 0.1 7.9e-32 109.9 0.1 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS52982.1 - 0.0061 16.6 0.0 0.021 14.8 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Phage_integrase PF00589.22 AAS52982.1 - 0.068 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Phage integrase family GTP1_OBG PF01018.22 AAS52983.1 - 7.2e-36 123.1 5.1 7.8e-26 90.5 5.1 2.4 2 0 0 2 2 2 2 GTP1/OBG MMR_HSR1 PF01926.23 AAS52983.1 - 5.2e-22 78.1 0.0 8.8e-22 77.4 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS52983.1 - 1.4e-09 37.6 0.0 3.4e-09 36.4 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Arf PF00025.21 AAS52983.1 - 8.2e-09 35.2 0.0 1.9e-08 34.0 0.0 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Dynamin_N PF00350.23 AAS52983.1 - 0.0004 20.5 0.0 0.34 10.9 0.0 2.3 1 1 1 2 2 2 2 Dynamin family Ras PF00071.22 AAS52983.1 - 0.0023 17.5 0.0 0.0061 16.2 0.0 1.7 1 1 0 1 1 1 1 Ras family SRPRB PF09439.10 AAS52983.1 - 0.0026 17.2 0.0 0.0049 16.3 0.0 1.3 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 AAS52983.1 - 0.043 13.8 0.0 0.09 12.8 0.0 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain MSC PF09402.10 AAS52984.2 - 7e-112 374.2 2.0 7e-112 374.2 2.0 2.1 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain HeH PF12949.7 AAS52984.2 - 9.7e-14 50.8 0.2 2.9e-13 49.3 0.2 1.9 1 0 0 1 1 1 1 HeH/LEM domain DUF356 PF04009.12 AAS52984.2 - 0.13 12.5 0.2 0.42 10.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF356) HECT PF00632.25 AAS52985.2 - 4e-91 305.7 0.1 1.7e-90 303.6 0.0 2.2 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) DUF908 PF06012.12 AAS52985.2 - 6.5e-61 206.7 4.7 6.3e-59 200.2 4.7 2.7 1 1 0 1 1 1 1 Domain of Unknown Function (DUF908) DUF913 PF06025.12 AAS52985.2 - 3.8e-53 180.8 6.4 1.9e-52 178.5 0.0 3.2 3 0 0 3 3 3 2 Domain of Unknown Function (DUF913) UBM PF14377.6 AAS52985.2 - 2.5e-14 52.2 2.2 4.6e-08 32.2 0.1 2.7 2 0 0 2 2 2 2 Ubiquitin binding region Rad52_Rad22 PF04098.15 AAS52986.1 - 2.1e-56 190.1 0.0 3e-56 189.6 0.0 1.2 1 0 0 1 1 1 1 Rad52/22 family double-strand break repair protein Ndc1_Nup PF09531.10 AAS52987.2 - 5.4e-97 326.0 20.9 3.2e-96 323.4 20.9 1.8 1 1 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Na_H_Exchanger PF00999.21 AAS52988.1 - 4.8e-66 223.1 37.4 6.3e-66 222.7 37.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Myc_target_1 PF15179.6 AAS52988.1 - 0.28 11.1 1.3 0.63 9.9 1.3 1.5 1 0 0 1 1 1 0 Myc target protein 1 Guanylate_kin PF00625.21 AAS52989.1 - 5.4e-69 231.5 0.0 6e-69 231.4 0.0 1.0 1 0 0 1 1 1 1 Guanylate kinase AAA_16 PF13191.6 AAS52989.1 - 3.7e-07 30.7 0.2 1.1e-06 29.1 0.2 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AAS52989.1 - 6.7e-07 29.9 0.0 9.3e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AAS52989.1 - 2.1e-05 24.7 0.0 0.00014 22.0 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AAS52989.1 - 3.3e-05 24.2 0.0 0.00025 21.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 AAS52989.1 - 9.8e-05 22.4 0.0 0.00059 19.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AAS52989.1 - 0.00082 19.9 0.1 0.001 19.6 0.1 1.6 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 AAS52989.1 - 0.0022 17.9 0.0 0.004 17.1 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 AAS52989.1 - 0.0023 18.2 0.0 0.0045 17.2 0.0 1.6 2 0 0 2 2 1 1 AAA domain AAA_29 PF13555.6 AAS52989.1 - 0.0033 17.1 0.5 0.014 15.1 0.1 2.1 2 1 0 2 2 2 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 AAS52989.1 - 0.0033 17.8 0.0 0.01 16.2 0.0 1.7 2 1 0 2 2 1 1 RNA helicase NACHT PF05729.12 AAS52989.1 - 0.0061 16.5 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_14 PF13173.6 AAS52989.1 - 0.0085 16.1 0.0 0.022 14.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 AAS52989.1 - 0.0092 16.4 0.1 0.066 13.6 0.0 2.1 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 AAS52989.1 - 0.0094 15.7 0.1 0.045 13.5 0.0 1.9 1 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS52989.1 - 0.011 15.4 0.1 0.021 14.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain NTPase_1 PF03266.15 AAS52989.1 - 0.012 15.5 0.0 0.029 14.3 0.0 1.8 1 1 1 2 2 2 0 NTPase DUF2075 PF09848.9 AAS52989.1 - 0.016 14.5 0.0 0.019 14.2 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AAS52989.1 - 0.019 14.0 0.0 0.032 13.3 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein cobW PF02492.19 AAS52989.1 - 0.019 14.6 0.0 0.056 13.0 0.0 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.18 AAS52989.1 - 0.027 14.2 0.0 0.048 13.4 0.0 1.5 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase KAP_NTPase PF07693.14 AAS52989.1 - 0.032 13.5 0.2 0.072 12.3 0.2 1.7 1 1 0 1 1 1 0 KAP family P-loop domain Rad17 PF03215.15 AAS52989.1 - 0.033 14.1 0.0 0.044 13.7 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 AAS52989.1 - 0.036 14.6 0.2 0.078 13.5 0.2 1.5 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AAS52989.1 - 0.054 13.0 0.0 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase_2 PF01637.18 AAS52989.1 - 0.062 13.2 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Cytidylate_kin PF02224.18 AAS52989.1 - 0.065 13.0 0.1 0.15 11.8 0.1 1.7 1 1 0 1 1 1 0 Cytidylate kinase Zeta_toxin PF06414.12 AAS52989.1 - 0.08 12.2 0.1 0.22 10.8 0.0 1.7 2 0 0 2 2 2 0 Zeta toxin MobB PF03205.14 AAS52989.1 - 0.081 12.8 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B TsaE PF02367.17 AAS52989.1 - 0.097 12.7 0.0 0.76 9.8 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE dNK PF01712.19 AAS52989.1 - 0.098 12.5 0.0 0.24 11.2 0.0 1.6 2 0 0 2 2 2 0 Deoxynucleoside kinase AAA_17 PF13207.6 AAS52989.1 - 0.099 13.1 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AAS52989.1 - 0.14 11.3 0.0 0.26 10.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Adeno_IVa2 PF02456.15 AAS52989.1 - 0.15 10.8 0.0 0.27 10.0 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein AAA_5 PF07728.14 AAS52989.1 - 0.15 12.0 0.5 1.6 8.7 0.1 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) HIG_1_N PF04588.13 AAS52990.1 - 9.3e-16 57.8 0.4 1.3e-15 57.3 0.4 1.2 1 0 0 1 1 1 1 Hypoxia induced protein conserved region DUF4407 PF14362.6 AAS52990.1 - 0.015 14.7 1.4 0.018 14.4 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PsbJ PF01788.17 AAS52990.1 - 0.032 14.1 0.1 0.052 13.4 0.1 1.3 1 0 0 1 1 1 0 PsbJ PEARLI-4 PF05278.12 AAS52990.1 - 0.054 13.1 5.2 0.074 12.6 5.2 1.2 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Gram_pos_anchor PF00746.21 AAS52990.1 - 1.7 8.6 4.0 12 5.9 0.1 2.6 3 0 0 3 3 3 0 LPXTG cell wall anchor motif Spc7 PF08317.11 AAS52990.1 - 5.3 5.8 18.3 13 4.6 0.1 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein ubiquitin PF00240.23 AAS52991.2 - 0.0012 18.5 0.0 0.0074 16.0 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 AAS52991.2 - 0.14 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF1533 PF07550.11 AAS52991.2 - 0.15 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) AhpC-TSA PF00578.21 AAS52992.1 - 3.5e-34 117.4 0.0 1e-33 115.9 0.0 1.6 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 AAS52992.1 - 3.9e-18 65.6 0.1 7.5e-18 64.6 0.0 1.4 2 0 0 2 2 2 1 Redoxin 1-cysPrx_C PF10417.9 AAS52992.1 - 1.4e-08 34.5 0.2 2.5e-08 33.6 0.2 1.5 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 AAS52992.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 SCO1/SenC Metallophos PF00149.28 AAS52993.2 - 1e-06 29.4 0.4 1.7e-06 28.7 0.4 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Homeodomain PF00046.29 AAS52994.1 - 5.2e-18 64.6 7.6 1e-17 63.7 7.6 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AAS52994.1 - 0.00017 21.4 0.4 0.00063 19.6 0.4 2.0 1 0 0 1 1 1 1 Homeobox KN domain Ribosomal_S13 PF00416.22 AAS52995.1 - 1.5e-57 193.5 2.5 1.7e-57 193.3 2.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S13/S18 FbpA PF05833.11 AAS52995.1 - 0.00091 18.1 0.0 0.0011 17.8 0.0 1.3 1 1 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) HHH_6 PF14579.6 AAS52995.1 - 0.1 12.9 0.2 0.44 10.8 0.1 2.1 1 1 0 1 1 1 0 Helix-hairpin-helix motif Ribosomal_L4 PF00573.22 AAS52996.2 - 1.4e-50 171.7 0.0 1.7e-50 171.4 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family U3_assoc_6 PF08640.11 AAS52997.2 - 2.6e-33 113.9 2.7 3.5e-31 107.1 0.7 2.9 2 1 0 2 2 2 2 U3 small nucleolar RNA-associated protein 6 Suf PF05843.14 AAS52997.2 - 3.5e-05 24.0 2.9 0.0015 18.6 0.4 3.1 2 1 0 2 2 2 1 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 AAS52997.2 - 4.8e-05 22.7 3.4 0.0091 15.2 0.5 2.4 1 1 1 2 2 2 2 NRDE-2, necessary for RNA interference TPR_14 PF13428.6 AAS52997.2 - 0.00056 20.5 0.0 1.3 10.1 0.0 3.0 1 1 2 3 3 3 2 Tetratricopeptide repeat Sfi1 PF08457.10 AAS52997.2 - 0.02 13.4 0.0 0.035 12.7 0.0 1.3 1 0 0 1 1 1 0 Sfi1 spindle body protein TPR_17 PF13431.6 AAS52997.2 - 0.036 14.4 2.7 8 7.1 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat HAT PF02184.16 AAS52997.2 - 0.059 13.4 0.4 0.36 10.8 0.0 2.3 2 0 0 2 2 2 0 HAT (Half-A-TPR) repeat ZZ PF00569.17 AAS52998.1 - 4.1e-16 58.5 7.8 8.3e-16 57.5 7.8 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type SWIRM PF04433.17 AAS52998.1 - 6.2e-09 36.1 0.2 9.3e-08 32.3 0.0 2.6 2 0 0 2 2 2 1 SWIRM domain Myb_DNA-binding PF00249.31 AAS52998.1 - 4e-08 33.3 0.0 1e-07 32.0 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS52998.1 - 0.00017 21.7 0.0 0.00045 20.4 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain Ribosomal_S17e PF00833.18 AAS52999.1 - 2.8e-56 188.7 0.6 3.4e-56 188.4 0.6 1.1 1 0 0 1 1 1 1 Ribosomal S17 ECM11 PF15463.6 AAS53000.1 - 2e-16 60.8 1.0 3.5e-16 60.0 0.1 2.0 2 0 0 2 2 2 1 Extracellular mutant protein 11 CREPT PF16566.5 AAS53000.1 - 0.18 12.0 3.8 0.12 12.5 0.6 2.0 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour RPAP1_N PF08621.10 AAS53000.1 - 0.52 10.1 4.3 4.8 7.0 4.3 2.5 1 1 0 1 1 1 0 RPAP1-like, N-terminal FAD-oxidase_C PF02913.19 AAS53001.1 - 4.9e-57 193.4 0.0 7.4e-57 192.8 0.0 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AAS53001.1 - 7.4e-36 122.9 0.1 1.4e-35 122.1 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain YceG_bac PF14266.6 AAS53001.1 - 0.081 11.8 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 Putative component of 'biosynthetic module' DUF676 PF05057.14 AAS53002.2 - 1.2e-47 162.2 0.0 1.9e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AAS53002.2 - 0.00093 19.1 0.1 0.0051 16.7 0.0 2.1 3 0 0 3 3 3 1 Palmitoyl protein thioesterase Lipase_3 PF01764.25 AAS53002.2 - 0.0048 16.8 0.0 0.012 15.5 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) DUF915 PF06028.11 AAS53002.2 - 0.013 14.9 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Abhydrolase_6 PF12697.7 AAS53002.2 - 0.049 14.2 0.1 0.17 12.4 0.1 2.1 1 1 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS53002.2 - 0.074 12.3 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 Serine aminopeptidase, S33 PGAP1 PF07819.13 AAS53002.2 - 0.5 10.0 1.9 0.41 10.3 0.2 1.7 2 0 0 2 2 2 0 PGAP1-like protein Med13_N PF11597.8 AAS53003.1 - 6.1e-63 213.1 0.1 1e-62 212.4 0.1 1.4 1 0 0 1 1 1 1 Mediator complex subunit 13 N-terminal Med13_C PF06333.12 AAS53003.1 - 8.9e-26 90.9 6.9 8e-19 68.1 0.4 3.2 2 1 1 3 3 3 2 Mediator complex subunit 13 C-terminal domain Nse5 PF08691.10 AAS53004.2 - 3e-151 504.6 0.1 3.6e-151 504.3 0.1 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Pribosyltran PF00156.27 AAS53005.1 - 1.9e-15 56.8 0.0 2.5e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AAS53005.1 - 0.0058 16.1 0.0 0.008 15.6 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase DOT1 PF08123.13 AAS53006.2 - 1.1e-89 299.4 0.0 1.6e-89 298.9 0.0 1.2 1 0 0 1 1 1 1 Histone methylation protein DOT1 CMAS PF02353.20 AAS53006.2 - 0.0053 16.1 0.0 0.01 15.1 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UDG PF03167.19 AAS53007.1 - 6.1e-22 78.3 0.0 9.3e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily ydhR PF08803.11 AAS53008.1 - 0.13 12.2 0.0 0.4 10.6 0.0 1.8 1 0 0 1 1 1 0 Putative mono-oxygenase ydhR LRS4 PF10422.9 AAS53009.2 - 4.7e-47 160.7 0.0 6.7e-47 160.2 0.0 1.2 1 0 0 1 1 1 1 Monopolin complex subunit LRS4 APG6_N PF17675.1 AAS53009.2 - 0.01 16.4 1.5 0.014 15.9 1.5 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region OST3_OST6 PF04756.13 AAS53010.2 - 9.2e-68 228.7 0.9 1.1e-67 228.4 0.9 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family EamA PF00892.20 AAS53011.1 - 1.2e-13 51.4 33.7 8.9e-08 32.4 11.5 3.0 3 0 0 3 3 3 2 EamA-like transporter family SLC35F PF06027.12 AAS53011.1 - 6.1e-06 26.0 9.3 6.1e-06 26.0 9.3 1.7 2 0 0 2 2 2 1 Solute carrier family 35 DUF3955 PF13127.6 AAS53011.1 - 0.0049 16.7 0.5 0.0049 16.7 0.5 4.1 5 1 1 6 6 6 1 Protein of unknown function (DUF3955) 7tm_7 PF08395.12 AAS53011.1 - 0.02 14.1 0.3 0.02 14.1 0.3 2.8 3 1 0 3 3 3 0 7tm Chemosensory receptor PUNUT PF16913.5 AAS53011.1 - 2.8 7.1 22.6 0.013 14.8 9.8 2.7 2 1 1 3 3 3 0 Purine nucleobase transmembrane transport PIG-P PF08510.12 AAS53013.1 - 3e-36 124.0 1.1 3.5e-36 123.8 1.1 1.1 1 0 0 1 1 1 1 PIG-P Metallophos PF00149.28 AAS53014.2 - 2e-35 123.1 0.1 3.5e-35 122.4 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AAS53014.2 - 8.2e-19 67.8 0.3 1.7e-18 66.8 0.3 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain GHMP_kinases_N PF00288.26 AAS53015.1 - 7.7e-20 70.9 0.3 1.6e-19 69.9 0.3 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AAS53015.1 - 2.2e-07 31.1 0.3 8.5e-07 29.3 0.1 2.1 1 1 1 2 2 2 1 GHMP kinases C terminal GalKase_gal_bdg PF10509.9 AAS53015.1 - 0.073 12.6 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Galactokinase galactose-binding signature Mtc PF03820.17 AAS53016.1 - 7.5e-123 409.5 0.2 8.4e-123 409.4 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier WD40 PF00400.32 AAS53017.2 - 7.9e-24 83.5 8.5 9.3e-06 26.3 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat NLE PF08154.12 AAS53017.2 - 8.4e-23 80.7 0.1 1.7e-22 79.7 0.1 1.6 1 0 0 1 1 1 1 NLE (NUC135) domain Nup160 PF11715.8 AAS53017.2 - 2.9e-08 32.8 8.1 0.00011 21.0 0.8 3.3 1 1 2 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 AAS53017.2 - 0.041 14.2 1.1 0.53 10.6 0.1 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain N2227 PF07942.12 AAS53018.1 - 1.5e-74 250.6 0.1 2e-74 250.2 0.1 1.1 1 0 0 1 1 1 1 N2227-like protein MFS_1 PF07690.16 AAS53019.1 - 2.3e-28 99.1 39.2 2.3e-28 99.1 39.2 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS53019.1 - 1.6e-07 30.6 19.0 1.9e-07 30.3 0.0 4.0 2 1 1 4 4 4 2 Sugar (and other) transporter TRI12 PF06609.13 AAS53019.1 - 0.0032 16.0 4.0 0.0032 16.0 4.0 1.6 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) Tubulin_3 PF14881.6 AAS53020.1 - 9.3e-23 80.8 0.0 1.5e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain Misat_Tub_SegII PF10644.9 AAS53020.1 - 2.2e-15 57.0 0.0 4.3e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin PF00091.25 AAS53020.1 - 0.067 13.4 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain IPPT PF01715.17 AAS53021.1 - 1.2e-66 224.8 0.2 1.8e-66 224.3 0.2 1.2 1 0 0 1 1 1 1 IPP transferase AAA_33 PF13671.6 AAS53021.1 - 0.0005 20.2 0.0 0.02 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA domain IPT PF01745.16 AAS53021.1 - 0.00062 19.2 0.1 0.0093 15.4 0.0 2.8 3 1 1 4 4 4 1 Isopentenyl transferase AAA_16 PF13191.6 AAS53021.1 - 0.0031 17.9 0.1 0.0071 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AAS53021.1 - 0.0093 16.5 0.2 0.033 14.7 0.1 2.0 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AAS53021.1 - 0.024 13.9 0.0 0.055 12.7 0.0 1.6 1 0 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 AAS53021.1 - 0.068 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ParA PF10609.9 AAS53021.1 - 0.072 12.5 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase IstB_IS21 PF01695.17 AAS53021.1 - 0.075 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_22 PF13401.6 AAS53021.1 - 0.088 13.1 0.0 0.51 10.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 AAS53021.1 - 0.13 11.8 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 HPr Serine kinase C-terminal domain BRO1 PF03097.18 AAS53022.1 - 4.4e-87 292.4 2.7 6.4e-87 291.9 2.7 1.2 1 0 0 1 1 1 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 AAS53022.1 - 2.7e-15 56.4 6.6 2.8e-15 56.4 3.9 2.2 1 1 0 2 2 2 1 ALIX V-shaped domain binding to HIV SesA PF17107.5 AAS53022.1 - 0.11 12.6 0.6 2.4 8.4 0.1 3.0 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Fanconi_A_N PF15865.5 AAS53023.2 - 0.0064 15.9 0.6 0.014 14.8 0.6 1.5 1 0 0 1 1 1 1 Fanconi anaemia group A protein N terminus Myb_DNA-binding PF00249.31 AAS53024.1 - 8.8e-18 64.2 0.4 7.1e-12 45.3 0.4 2.4 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS53024.1 - 9.3e-15 54.6 0.0 2.7e-11 43.6 0.0 2.4 1 1 1 2 2 2 2 Myb-like DNA-binding domain Rap1_C PF11626.8 AAS53024.1 - 3.3e-05 23.9 0.0 0.12 12.5 0.0 2.9 1 1 1 2 2 2 2 TRF2-interacting telomeric protein/Rap1 - C terminal domain CAF20 PF17052.5 AAS53025.1 - 6.3e-46 156.4 1.0 1.3e-45 155.4 1.0 1.5 1 1 0 1 1 1 1 Cap associated factor DnaJ PF00226.31 AAS53026.2 - 4.5e-27 94.0 1.4 7.6e-27 93.2 1.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 AAS53026.2 - 1.8e-23 83.2 0.0 2.3e-23 82.9 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AAS53026.2 - 4.9e-13 49.2 18.5 8.7e-13 48.4 18.5 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AAS53026.2 - 0.00014 21.7 10.4 0.032 14.2 1.2 2.5 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein HypA PF01155.19 AAS53026.2 - 0.79 9.8 12.9 1.4 9.0 2.1 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-RING_10 PF16685.5 AAS53026.2 - 1.1 9.5 9.5 0.35 11.1 6.0 1.9 1 1 1 2 2 2 0 zinc RING finger of MSL2 DUF1258 PF06869.12 AAS53026.2 - 3.5 7.0 11.3 0.23 10.9 1.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1258) TackOD1 PF18551.1 AAS53026.2 - 3.6 7.2 9.9 3.1 7.4 1.5 2.2 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 DZR PF12773.7 AAS53026.2 - 6.7 6.8 12.9 2.5e+02 1.8 12.9 2.2 1 1 0 1 1 1 0 Double zinc ribbon Glyco_hydro_72 PF03198.14 AAS53027.1 - 3.2e-121 404.4 2.7 4.3e-121 404.0 2.7 1.1 1 0 0 1 1 1 1 Glucanosyltransferase Glyco_hydro_2_C PF02836.17 AAS53027.1 - 4.7e-07 29.2 0.5 8.2e-07 28.4 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Cellulase PF00150.18 AAS53027.1 - 0.00038 20.0 0.5 0.0036 16.8 0.5 2.2 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Cadherin_5 PF17892.1 AAS53027.1 - 0.065 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Cadherin-like domain Pkinase PF00069.25 AAS53028.2 - 3.6e-41 141.3 0.1 2e-19 70.0 0.2 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53028.2 - 1e-09 38.1 0.8 2.4e-05 23.7 0.4 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase RGCC PF15151.6 AAS53028.2 - 0.24 11.6 1.1 0.4 10.9 0.1 1.9 2 0 0 2 2 2 0 Response gene to complement 32 protein family RRM_1 PF00076.22 AAS53029.1 - 2.4e-09 36.9 0.0 3.5e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AAS53029.1 - 6.8e-08 32.4 0.0 9.5e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif GMP_synt_C PF00958.22 AAS53030.1 - 4.1e-45 151.8 0.0 7.9e-45 150.9 0.0 1.5 1 0 0 1 1 1 1 GMP synthase C terminal domain GATase PF00117.28 AAS53030.1 - 9.5e-43 146.2 0.0 1.7e-42 145.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I NAD_synthase PF02540.17 AAS53030.1 - 1.7e-07 30.6 0.0 3.6e-05 23.0 0.0 2.2 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 AAS53030.1 - 1.3e-06 28.4 0.2 7.7e-06 25.8 0.2 2.2 1 1 0 1 1 1 1 Peptidase C26 tRNA_Me_trans PF03054.16 AAS53030.1 - 0.004 16.0 0.0 0.0094 14.8 0.0 1.6 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 AAS53030.1 - 0.013 15.0 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC Arginosuc_synth PF00764.19 AAS53030.1 - 0.023 14.0 0.1 0.042 13.1 0.1 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase PAPS_reduct PF01507.19 AAS53030.1 - 0.055 13.5 0.0 0.095 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family ThiI PF02568.14 AAS53030.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) HEM4 PF02602.15 AAS53031.2 - 6.9e-47 159.7 0.0 7.8e-47 159.6 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD TRAPPC10 PF12584.8 AAS53032.2 - 1.4e-05 24.8 0.1 3.3e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Trafficking protein particle complex subunit 10, TRAPPC10 TPR_12 PF13424.6 AAS53032.2 - 0.14 12.4 1.0 3.2 8.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat GHMP_kinases_N PF00288.26 AAS53034.1 - 2.2e-15 56.6 0.1 4.6e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AAS53034.1 - 0.0002 21.6 0.0 0.00044 20.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases C terminal PilJ PF13675.6 AAS53034.1 - 0.0055 16.7 0.1 0.015 15.3 0.1 1.8 1 0 0 1 1 1 1 Type IV pili methyl-accepting chemotaxis transducer N-term DUF4880 PF16220.5 AAS53034.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4880) FSH1 PF03959.13 AAS53036.1 - 5.6e-60 202.6 0.0 6.4e-60 202.4 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_2 PF02230.16 AAS53036.1 - 0.0012 18.7 0.0 0.0026 17.6 0.0 1.6 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase DUF416 PF04222.12 AAS53036.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF416) CDP-OH_P_transf PF01066.21 AAS53037.1 - 4.8e-11 43.3 0.7 4.8e-11 43.3 0.7 1.8 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase ACOX PF01756.19 AAS53038.2 - 8.4e-43 146.0 0.1 1.4e-42 145.3 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA oxidase Acyl-CoA_dh_M PF02770.19 AAS53038.2 - 1.7e-22 79.4 0.1 4.9e-22 78.0 0.0 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_ox_N PF14749.6 AAS53038.2 - 2.3e-13 50.8 0.1 4.3e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A oxidase N-terminal Acyl-CoA_dh_1 PF00441.24 AAS53038.2 - 3.1e-07 30.7 0.0 3.5e-06 27.3 0.0 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain RPAP1_N PF08621.10 AAS53038.2 - 0.54 10.1 1.8 7.7 6.4 0.0 2.4 2 0 0 2 2 2 0 RPAP1-like, N-terminal Clathrin PF00637.20 AAS53039.2 - 1.5e-193 634.4 50.4 8.2e-31 106.8 2.1 8.3 8 0 0 8 8 8 7 Region in Clathrin and VPS Clathrin_H_link PF13838.6 AAS53039.2 - 1.5e-26 92.0 1.6 9.6e-26 89.5 0.1 2.8 2 0 0 2 2 2 1 Clathrin-H-link Clathrin_propel PF01394.20 AAS53039.2 - 2.6e-17 62.2 2.4 0.011 16.0 0.1 6.0 6 0 0 6 6 6 5 Clathrin propeller repeat Clathrin-link PF09268.10 AAS53039.2 - 4.1e-10 38.8 0.6 1.3e-09 37.2 0.6 1.9 1 0 0 1 1 1 1 Clathrin, heavy-chain linker Vps39_1 PF10366.9 AAS53039.2 - 1.9e-05 24.9 15.9 0.023 14.9 0.3 7.0 7 1 0 7 7 7 2 Vacuolar sorting protein 39 domain 1 TPR_1 PF00515.28 AAS53039.2 - 0.03 14.2 9.7 9.7 6.2 0.0 6.2 6 0 0 6 6 6 0 Tetratricopeptide repeat Rop PF01815.16 AAS53039.2 - 0.11 12.4 2.8 0.14 12.1 0.2 2.5 2 0 0 2 2 2 0 Rop protein TPR_12 PF13424.6 AAS53039.2 - 0.12 12.7 5.3 5.2 7.4 0.2 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS53039.2 - 0.38 10.9 10.7 28 5.0 0.0 6.7 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_19 PF14559.6 AAS53039.2 - 1.6 9.3 5.1 18 5.9 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat SPT16 PF08644.11 AAS53040.2 - 2e-50 170.9 0.1 2e-50 170.9 0.1 1.8 2 0 0 2 2 2 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 AAS53040.2 - 4.9e-45 153.2 0.4 8.3e-44 149.2 0.0 2.7 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 AAS53040.2 - 1.3e-31 109.9 0.0 2.3e-31 109.1 0.0 1.4 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 AAS53040.2 - 1.1e-13 51.3 0.1 1.3e-12 48.0 0.1 2.5 2 0 0 2 2 2 1 Histone chaperone Rttp106-like AMPK1_CBM PF16561.5 AAS53041.1 - 1.1e-28 99.3 0.0 1.9e-28 98.5 0.0 1.4 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase AMPKBI PF04739.15 AAS53041.1 - 1.1e-26 92.9 2.4 1.1e-26 92.9 2.4 2.7 2 1 0 2 2 2 1 5'-AMP-activated protein kinase beta subunit, interaction domain CBM53 PF16760.5 AAS53041.1 - 0.039 14.6 0.0 0.12 13.0 0.0 1.8 1 0 0 1 1 1 0 Starch/carbohydrate-binding module (family 53) tRNA-synt_2 PF00152.20 AAS53042.2 - 3.8e-58 197.0 0.0 4.8e-58 196.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS53042.2 - 8.8e-06 25.6 0.0 1.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AAS53042.2 - 1.2e-05 24.9 0.4 0.00071 19.1 0.0 2.5 2 1 1 3 3 3 1 tRNA synthetases class II core domain (F) tRNA_anti_2 PF13742.6 AAS53042.2 - 0.055 13.7 0.0 0.11 12.8 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain RNase_HII PF01351.18 AAS53043.2 - 2.6e-60 203.7 0.0 3.2e-60 203.4 0.0 1.1 1 0 0 1 1 1 1 Ribonuclease HII 2-oxoacid_dh PF00198.23 AAS53044.1 - 3.2e-75 252.6 0.0 4.3e-75 252.2 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AAS53044.1 - 6e-17 61.3 0.1 1.1e-16 60.4 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AAS53044.1 - 9.9e-17 61.0 0.3 7e-16 58.3 0.2 2.6 2 0 0 2 2 2 1 e3 binding domain Tom7 PF08038.12 AAS53045.1 - 1.7e-17 62.7 0.0 2.3e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 TOM7 family Mito_carr PF00153.27 AAS53046.1 - 1.1e-59 198.3 2.2 7.7e-21 73.8 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L13 PF00572.18 AAS53047.1 - 2e-11 44.3 0.1 2.5e-09 37.4 0.1 2.5 1 1 0 1 1 1 1 Ribosomal protein L13 CSM2 PF16834.5 AAS53048.1 - 8.4e-38 130.0 0.0 1e-37 129.8 0.0 1.0 1 0 0 1 1 1 1 Shu complex component Csm2, DNA-binding Forkhead PF00250.18 AAS53049.2 - 5.8e-35 119.4 1.0 1.8e-34 117.9 0.3 2.2 2 0 0 2 2 2 1 Forkhead domain FHA PF00498.26 AAS53049.2 - 4.5e-12 46.2 0.1 1.3e-11 44.7 0.1 1.9 1 0 0 1 1 1 1 FHA domain Linker_histone PF00538.19 AAS53049.2 - 0.0001 22.6 0.1 0.00028 21.2 0.1 1.8 1 0 0 1 1 1 1 linker histone H1 and H5 family Fungal_trans PF04082.18 AAS53050.2 - 3.9e-28 98.2 0.1 6.4e-28 97.5 0.1 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS53050.2 - 6.9e-11 42.1 12.0 1.3e-10 41.3 12.0 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain SUN PF03856.13 AAS53052.2 - 2.5e-98 328.4 8.4 3.4e-98 328.0 8.4 1.2 1 0 0 1 1 1 1 Beta-glucosidase (SUN family) PARM PF17061.5 AAS53052.2 - 0.072 13.2 28.6 0.1 12.7 28.6 1.2 1 0 0 1 1 1 0 PARM Apt1 PF10351.9 AAS53052.2 - 0.18 10.6 5.2 0.23 10.3 5.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SOG2 PF10428.9 AAS53052.2 - 1.2 8.2 20.2 1.7 7.7 20.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 AAS53052.2 - 9.6 4.6 7.8 14 4.1 7.8 1.2 1 0 0 1 1 1 0 Macoilin family adh_short PF00106.25 AAS53053.1 - 2e-49 167.7 0.0 2.5e-49 167.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS53053.1 - 4.1e-31 108.3 0.0 4.8e-31 108.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS53053.1 - 8.8e-11 42.0 0.0 1.3e-10 41.5 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AAS53053.1 - 6.3e-07 29.1 0.0 1.6e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AAS53053.1 - 1.6e-05 24.5 0.0 0.00023 20.7 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 AAS53053.1 - 6.1e-05 22.3 0.0 0.00011 21.5 0.0 1.4 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 AAS53053.1 - 0.00011 22.1 0.0 0.00017 21.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 AAS53053.1 - 0.045 13.1 0.0 0.22 10.9 0.0 1.9 2 0 0 2 2 2 0 GDP-mannose 4,6 dehydratase Sacchrp_dh_NADP PF03435.18 AAS53053.1 - 0.12 12.7 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Transket_pyr PF02779.24 AAS53054.2 - 1.1e-63 214.1 0.0 2.1e-63 213.2 0.0 1.5 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 AAS53054.2 - 4.5e-57 193.3 0.0 6.2e-57 192.8 0.0 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 AAS53054.2 - 1.4e-49 167.7 0.0 2.3e-49 167.0 0.0 1.3 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal 2-oxogl_dehyd_N PF16078.5 AAS53054.2 - 3.9e-20 71.1 1.9 3.9e-20 71.1 1.9 2.3 3 0 0 3 3 3 1 2-oxoglutarate dehydrogenase N-terminus SNF2_N PF00176.23 AAS53055.1 - 1.8e-76 257.2 0.8 5.1e-76 255.7 0.8 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS53055.1 - 1.3e-24 86.6 1.0 1.9e-19 70.0 0.0 3.8 3 0 0 3 3 3 2 Helicase conserved C-terminal domain Bromodomain PF00439.25 AAS53055.1 - 3.8e-16 58.9 0.1 9.9e-16 57.6 0.1 1.8 1 0 0 1 1 1 1 Bromodomain HSA PF07529.13 AAS53055.1 - 5.3e-12 45.9 12.4 5.3e-12 45.9 12.4 2.9 2 0 0 2 2 2 1 HSA ResIII PF04851.15 AAS53055.1 - 7.3e-11 42.4 4.1 8e-11 42.2 0.0 2.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SnAC PF14619.6 AAS53055.1 - 2.5e-08 34.4 1.7 2.5e-08 34.4 1.7 4.0 3 0 0 3 3 3 1 Snf2-ATP coupling, chromatin remodelling complex Ribosomal_S13 PF00416.22 AAS53055.1 - 0.081 13.3 3.2 0.41 11.0 3.2 2.3 1 0 0 1 1 1 0 Ribosomal protein S13/S18 RRT14 PF17075.5 AAS53056.2 - 4.9e-25 88.8 2.7 5.8e-25 88.6 2.7 1.0 1 0 0 1 1 1 1 Regular of rDNA transcription protein 14 MMS19_C PF12460.8 AAS53057.2 - 3.7e-88 296.5 9.4 1.2e-87 294.8 9.4 2.0 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal MMS19_N PF14500.6 AAS53057.2 - 1.8e-85 286.7 2.3 5e-82 275.4 0.1 3.4 3 0 0 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_EZ PF13513.6 AAS53057.2 - 2.3e-05 24.8 2.5 1.3 9.6 0.1 5.1 3 1 1 4 4 4 2 HEAT-like repeat HEAT_2 PF13646.6 AAS53057.2 - 0.0002 21.7 3.9 2.6 8.5 0.0 4.4 3 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 AAS53057.2 - 0.0014 18.7 3.6 0.025 14.6 1.5 3.3 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 AAS53057.2 - 0.0022 18.2 3.6 0.055 13.6 0.4 3.0 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 TyeA PF09059.10 AAS53057.2 - 0.0084 16.2 0.0 0.034 14.2 0.0 2.0 1 0 0 1 1 1 1 TyeA Vac14_Fab1_bd PF12755.7 AAS53057.2 - 0.0097 16.5 0.2 2 9.1 0.0 4.2 5 0 0 5 5 5 1 Vacuolar 14 Fab1-binding region FANCI_S2 PF14676.6 AAS53057.2 - 0.029 14.7 10.2 6.1 7.1 0.8 5.2 4 1 1 5 5 5 0 FANCI solenoid 2 Ribosomal_L50 PF10501.9 AAS53057.2 - 0.03 14.5 0.3 7 6.8 0.1 2.7 2 1 0 2 2 2 0 Ribosomal subunit 39S MOR2-PAG1_N PF14222.6 AAS53058.2 - 5.8e-178 593.3 10.9 1.3e-177 592.1 10.9 1.7 1 0 0 1 1 1 1 Cell morphogenesis N-terminal MOR2-PAG1_C PF14225.6 AAS53058.2 - 2.8e-87 292.8 0.4 2.8e-87 292.8 0.4 2.9 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 AAS53058.2 - 2.1e-25 88.6 10.8 1.6e-14 52.7 0.5 3.3 3 0 0 3 3 3 3 Cell morphogenesis central region ApoO PF09769.9 AAS53059.1 - 0.0032 17.4 0.1 2.6 8.0 0.0 2.4 2 0 0 2 2 2 2 Apolipoprotein O Aa_trans PF01490.18 AAS53060.2 - 4.9e-95 318.6 33.4 5.8e-95 318.4 33.4 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein AA_permease_2 PF13520.6 AAS53060.2 - 1.6e-07 30.6 43.8 1.7e-06 27.1 43.8 1.9 1 1 0 1 1 1 1 Amino acid permease COX2-transmemb PF09125.10 AAS53060.2 - 0.49 10.2 5.6 0.22 11.4 1.4 2.5 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane Secretin_N_2 PF07655.13 AAS53060.2 - 1.5 9.4 5.6 0.24 12.0 1.4 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain DNA_pol_B PF00136.21 AAS53061.1 - 1.5e-117 393.1 0.7 2.4e-117 392.5 0.7 1.3 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 AAS53061.1 - 1.9e-65 220.1 0.5 3.7e-65 219.1 0.5 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DNA_pol_B_exo1 PF03104.19 AAS53061.1 - 2.7e-47 161.5 0.0 5.4e-47 160.6 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_alpha_N PF12254.8 AAS53061.1 - 8.5e-17 61.0 4.4 3.3e-16 59.1 4.4 2.1 1 0 0 1 1 1 1 DNA polymerase alpha subunit p180 N terminal zinc_ribbon_4 PF13717.6 AAS53061.1 - 0.00021 21.1 1.2 0.034 14.1 0.1 2.6 2 0 0 2 2 2 2 zinc-ribbon domain DNA_pol_B_2 PF03175.13 AAS53061.1 - 0.024 13.5 0.2 0.086 11.7 0.0 1.8 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral DUF1744 PF08490.12 AAS53061.1 - 0.036 12.6 0.0 0.072 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1744) Zn-ribbon_8 PF09723.10 AAS53061.1 - 0.084 13.0 0.7 5.3 7.2 0.1 2.9 2 0 0 2 2 2 0 Zinc ribbon domain HSP20 PF00011.21 AAS53062.1 - 6.5e-14 51.9 0.0 8.1e-14 51.6 0.0 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family DUF3857 PF12969.7 AAS53062.1 - 0.046 13.8 0.0 0.064 13.3 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3857) Motile_Sperm PF00635.26 AAS53062.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Secretin_N PF03958.17 AAS53062.1 - 0.16 12.4 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 Bacterial type II/III secretion system short domain Fasciclin PF02469.22 AAS53063.2 - 1e-06 29.0 0.0 2.3e-06 27.9 0.0 1.6 1 1 0 1 1 1 1 Fasciclin domain BOF PF04076.13 AAS53063.2 - 0.11 12.5 0.0 0.33 11.0 0.0 1.7 2 0 0 2 2 2 0 Bacterial OB fold (BOF) protein HLH PF00010.26 AAS53064.2 - 2.2e-19 69.1 0.8 4.6e-19 68.1 0.8 1.6 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain Sugar_tr PF00083.24 AAS53065.1 - 1.8e-54 185.3 29.5 4.6e-53 180.7 29.5 2.0 1 1 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53065.1 - 5.7e-13 48.5 45.1 1.8e-06 27.1 21.5 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily BT1 PF03092.16 AAS53065.1 - 0.069 11.4 9.2 0.19 9.9 0.4 2.8 3 0 0 3 3 3 0 BT1 family DMT_YdcZ PF04657.13 AAS53065.1 - 3.3 8.0 20.4 0.042 14.1 3.6 3.7 3 1 0 3 3 3 0 Putative inner membrane exporter, YdcZ XPG_N PF00752.17 AAS53066.2 - 8.2e-24 84.0 0.0 1.8e-23 82.9 0.0 1.6 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AAS53066.2 - 3.3e-20 72.2 0.0 8.3e-20 71.0 0.0 1.7 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 AAS53066.2 - 0.011 16.3 0.0 0.037 14.6 0.0 1.8 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 AAS53066.2 - 0.073 12.5 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 XPG domain containing Ank_2 PF12796.7 AAS53067.1 - 2.3e-32 111.4 0.0 5.5e-13 49.3 0.0 3.7 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) DHHC PF01529.20 AAS53067.1 - 1.2e-26 93.4 6.8 1.2e-26 93.4 6.8 2.6 2 1 0 2 2 2 1 DHHC palmitoyltransferase Ank_5 PF13857.6 AAS53067.1 - 2.1e-26 91.6 0.4 1.2e-07 31.8 0.0 4.9 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 AAS53067.1 - 1.1e-25 88.9 0.9 1.7e-05 25.0 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 AAS53067.1 - 2.4e-25 88.6 0.6 4.2e-09 36.8 0.0 5.4 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 AAS53067.1 - 5.7e-23 78.5 0.1 0.0014 18.9 0.0 5.9 5 0 0 5 5 5 4 Ankyrin repeat UNC45-central PF11701.8 AAS53068.2 - 6.5e-21 74.9 0.5 6.5e-21 74.9 0.5 3.6 4 0 0 4 4 4 1 Myosin-binding striated muscle assembly central Sec23_helical PF04815.15 AAS53068.2 - 0.043 13.6 0.4 1.1 9.2 0.0 2.7 2 0 0 2 2 2 0 Sec23/Sec24 helical domain RNase_J_C PF17770.1 AAS53068.2 - 0.16 13.0 0.0 0.86 10.7 0.0 2.3 1 0 0 1 1 1 0 Ribonuclease J C-terminal domain Imm30 PF15565.6 AAS53068.2 - 0.19 11.8 3.6 2.4 8.3 0.2 4.0 4 0 0 4 4 4 0 Immunity protein 30 Arm PF00514.23 AAS53068.2 - 0.56 10.3 0.0 0.56 10.3 0.0 4.9 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat BatA PF07584.11 AAS53068.2 - 3.2 8.2 6.7 8.2 6.9 1.0 3.0 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal FANC_SAP PF18081.1 AAS53068.2 - 8.2 6.7 6.4 1.3e+02 2.8 6.4 3.0 1 1 0 1 1 1 0 Fanconi anemia-associated nuclease SAP domain Pex2_Pex12 PF04757.14 AAS53069.1 - 1e-33 116.9 4.9 1.3e-33 116.5 4.9 1.1 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 AAS53069.1 - 8.9e-09 35.5 16.8 1.4e-08 34.9 16.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 AAS53069.1 - 5.2e-08 32.6 18.4 7.5e-08 32.1 18.4 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS53069.1 - 1.7e-06 27.8 17.1 2.9e-06 27.0 17.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS53069.1 - 4.1e-06 26.6 15.5 6.7e-06 25.9 15.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS53069.1 - 6.4e-06 25.9 16.8 9.5e-06 25.4 16.8 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 AAS53069.1 - 4.1e-05 23.5 8.2 4.1e-05 23.5 8.2 1.8 1 1 1 2 2 2 1 RING-type zinc-finger zf-rbx1 PF12678.7 AAS53069.1 - 0.00037 20.7 12.6 0.00062 20.0 12.6 1.4 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 AAS53069.1 - 0.00039 20.5 15.9 0.00076 19.6 15.9 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AAS53069.1 - 0.00039 20.3 12.4 0.00075 19.4 12.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 AAS53070.1 - 1.3e-09 37.8 8.0 1.3e-09 37.8 8.0 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS53070.1 - 9.8e-05 22.1 9.2 9.8e-05 22.1 9.2 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS53070.1 - 0.008 16.0 7.1 0.008 16.0 7.1 3.0 5 0 0 5 5 5 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 AAS53070.1 - 0.0088 16.4 8.6 0.0088 16.4 8.6 3.2 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_4 PF15227.6 AAS53070.1 - 4.9 7.4 7.5 18 5.6 7.5 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 AAS53070.1 - 6.4 6.7 24.5 0.039 13.8 9.4 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) PGP_phosphatase PF09419.10 AAS53071.1 - 7.5e-72 240.4 0.0 8.6e-72 240.2 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase Hydrolase_like PF13242.6 AAS53071.1 - 1.1e-07 31.7 0.1 2.4e-07 30.7 0.1 1.6 1 1 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AAS53071.1 - 3.5e-06 27.5 0.0 5.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Lipase_GDSL_2 PF13472.6 AAS53071.1 - 0.13 12.7 0.1 0.18 12.2 0.1 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family FAT PF02259.23 AAS53072.2 - 2.4e-71 240.8 9.5 2.4e-71 240.8 9.5 2.5 2 0 0 2 2 2 1 FAT domain PI3_PI4_kinase PF00454.27 AAS53072.2 - 3.7e-48 164.5 0.4 1.2e-47 162.8 0.4 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 AAS53072.2 - 0.00054 19.7 0.0 0.0019 18.0 0.0 2.1 1 0 0 1 1 1 1 FATC domain PXA PF02194.15 AAS53072.2 - 0.0062 16.5 4.4 0.35 10.8 0.1 4.0 3 0 0 3 3 3 1 PXA domain SesA PF17107.5 AAS53072.2 - 0.24 11.6 4.5 2.6 8.2 0.2 4.0 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases U3snoRNP10 PF12397.8 AAS53072.2 - 0.8 10.1 12.4 1.2 9.6 0.0 5.7 6 0 0 6 6 6 0 U3 small nucleolar RNA-associated protein 10 tRNA-synt_1 PF00133.22 AAS53073.2 - 1.2e-236 786.7 0.7 3.7e-236 785.1 0.1 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AAS53073.2 - 4.2e-27 95.0 0.0 1.2e-26 93.5 0.0 1.8 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AAS53073.2 - 7e-16 58.0 1.1 2.1e-05 23.4 0.2 4.0 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AAS53073.2 - 0.00016 21.1 0.0 0.0018 17.7 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain DUF1151 PF06625.11 AAS53074.1 - 0.34 10.9 5.8 0.33 10.9 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) HDV_ag PF01517.18 AAS53074.1 - 7.2 6.4 6.9 1.1 9.0 1.9 1.9 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen Atg8 PF02991.16 AAS53075.1 - 1.2e-47 160.4 0.1 1.4e-47 160.2 0.1 1.0 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 AAS53075.1 - 1.4e-07 31.8 0.0 1.8e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 Nucleoporin_N PF08801.11 AAS53076.1 - 4.2e-139 464.0 10.9 8e-139 463.1 10.9 1.5 1 0 0 1 1 1 1 Nup133 N terminal like Nucleoporin_C PF03177.14 AAS53076.1 - 8.2e-131 437.6 10.1 4.8e-130 435.1 10.1 1.9 1 1 0 1 1 1 1 Non-repetitive/WGA-negative nucleoporin C-terminal DUF2240 PF09999.9 AAS53076.1 - 0.13 11.9 0.6 0.76 9.4 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2240) DUF3947 PF13135.6 AAS53076.1 - 0.86 9.8 3.4 1.6 9.0 0.7 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3947) LRR_4 PF12799.7 AAS53077.1 - 2.3e-06 27.8 10.8 2.8 8.5 0.1 6.9 5 1 1 6 6 6 3 Leucine Rich repeats (2 copies) F-box-like PF12937.7 AAS53077.1 - 8.7e-06 25.5 0.1 2.8e-05 23.9 0.1 2.0 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS53077.1 - 0.011 15.5 0.0 0.044 13.7 0.0 2.1 1 0 0 1 1 1 0 F-box domain Preseq_ALAS PF09029.10 AAS53077.1 - 0.021 15.3 0.1 0.082 13.4 0.0 2.1 2 0 0 2 2 2 0 5-aminolevulinate synthase presequence LRR_6 PF13516.6 AAS53077.1 - 0.21 11.7 10.0 27 5.1 0.0 7.8 10 0 0 10 10 10 0 Leucine Rich repeat DNApol3-delta_C PF09115.10 AAS53078.2 - 0.053 14.0 0.1 0.14 12.6 0.1 1.7 1 0 0 1 1 1 0 DNA polymerase III, delta subunit, C terminal AT_hook PF02178.19 AAS53078.2 - 8.6 6.6 73.7 0.053 13.4 0.7 7.8 7 0 0 7 7 7 0 AT hook motif eIF-5_eIF-2B PF01873.17 AAS53079.2 - 2.5e-38 130.6 0.0 4.5e-38 129.7 0.0 1.4 1 0 0 1 1 1 1 Domain found in IF2B/IF5 W2 PF02020.18 AAS53079.2 - 2.1e-21 75.8 0.1 1.2e-20 73.5 0.0 2.2 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Zn-ribbon_8 PF09723.10 AAS53079.2 - 0.33 11.1 0.9 0.89 9.7 0.9 1.7 1 0 0 1 1 1 0 Zinc ribbon domain Aldo_ket_red PF00248.21 AAS53080.1 - 4.7e-48 163.9 0.0 1.4e-46 159.0 0.0 2.0 1 1 0 1 1 1 1 Aldo/keto reductase family TT1725 PF18324.1 AAS53080.1 - 0.059 13.5 0.0 0.25 11.5 0.0 2.0 2 0 0 2 2 2 0 Hypothetical protein TT1725 BRCT PF00533.26 AAS53081.1 - 5.7e-06 26.6 0.0 3.7e-05 24.0 0.0 2.3 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain Yop-YscD_cpl PF16697.5 AAS53081.1 - 2.6e-05 24.5 0.0 5.8e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 AAS53081.1 - 0.0016 18.8 0.0 0.0042 17.4 0.0 1.8 1 0 0 1 1 1 1 FHA domain Bac_surface_Ag PF01103.23 AAS53082.2 - 5.9e-24 85.2 0.3 7.2e-24 84.9 0.3 1.1 1 0 0 1 1 1 1 Surface antigen Hph PF13694.6 AAS53082.2 - 0.12 12.7 0.1 0.38 11.0 0.0 1.9 2 0 0 2 2 2 0 Sec63/Sec62 complex-interacting family RAI1 PF08652.11 AAS53083.2 - 2.9e-07 30.6 0.0 1.5e-06 28.2 0.0 2.0 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease AA_permease PF00324.21 AAS53084.2 - 1.9e-112 376.3 31.3 2.2e-112 376.1 31.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS53084.2 - 4.6e-38 131.1 33.3 5.6e-38 130.9 33.3 1.1 1 0 0 1 1 1 1 Amino acid permease PRK PF00485.18 AAS53086.1 - 2.1e-12 47.2 0.1 1.5e-11 44.4 0.0 1.9 1 1 1 2 2 2 1 Phosphoribulokinase / Uridine kinase family DEAD PF00270.29 AAS53087.2 - 7.6e-44 149.6 2.4 1.4e-43 148.7 2.4 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53087.2 - 2.5e-33 114.7 0.2 8.2e-32 109.9 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 AAS53087.2 - 0.0003 21.1 0.3 0.0024 18.2 0.3 2.1 1 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS53087.2 - 0.00031 20.5 0.4 0.00062 19.5 0.4 1.4 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 AAS53087.2 - 0.00066 19.7 0.1 0.0014 18.6 0.0 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS53087.2 - 0.036 14.3 0.5 0.14 12.4 0.5 1.9 1 1 0 1 1 1 0 AAA domain Helicase_RecD PF05127.14 AAS53087.2 - 0.038 13.8 0.0 0.079 12.8 0.0 1.7 1 1 0 1 1 1 0 Helicase Flavi_DEAD PF07652.14 AAS53087.2 - 0.061 13.3 0.1 0.14 12.2 0.1 1.6 1 1 0 1 1 1 0 Flavivirus DEAD domain TniB PF05621.11 AAS53087.2 - 0.12 11.8 0.1 0.25 10.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein Atg31 PF09795.9 AAS53088.1 - 7.1e-20 71.6 5.6 1.5e-19 70.6 5.6 1.5 1 1 0 1 1 1 1 Autophagy-related protein 31 Tox-REase-7 PF15649.6 AAS53088.1 - 0.09 13.1 0.1 0.59 10.5 0.0 2.0 1 1 0 2 2 2 0 Restriction endonuclease fold toxin 7 DNA_topoisoIV PF00521.20 AAS53089.1 - 1e-122 410.1 1.6 2.7e-122 408.7 0.1 2.2 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 AAS53089.1 - 2.2e-47 160.5 0.8 7.6e-47 158.8 0.8 2.0 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 AAS53089.1 - 6.2e-25 87.7 1.3 1.2e-24 86.7 1.3 1.5 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 AAS53089.1 - 4.7e-13 49.6 0.0 1.8e-12 47.7 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 AAS53089.1 - 2.5e-08 34.1 0.0 1.1e-07 31.9 0.0 2.2 1 0 0 1 1 1 1 Toprim domain Phasin PF05597.11 AAS53089.1 - 0.16 12.0 1.5 31 4.6 0.1 3.6 3 0 0 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) SOG2 PF10428.9 AAS53089.1 - 2.8 7.1 10.1 6.1 5.9 10.1 1.6 1 0 0 1 1 1 0 RAM signalling pathway protein C2 PF00168.30 AAS53090.1 - 1.8e-59 198.4 1.8 2.6e-21 75.8 0.0 4.6 4 0 0 4 4 4 4 C2 domain Tmemb_cc2 PF10267.9 AAS53091.1 - 2.9e-05 23.4 1.5 3e-05 23.4 1.5 1.0 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein DUF4763 PF15960.5 AAS53091.1 - 0.0041 16.4 1.7 0.0044 16.4 1.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) BLOC1_2 PF10046.9 AAS53091.1 - 0.0059 16.9 1.8 0.007 16.6 1.8 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Snapin_Pallidin PF14712.6 AAS53091.1 - 0.017 15.6 2.3 0.021 15.2 2.3 1.1 1 0 0 1 1 1 0 Snapin/Pallidin Dsl1_N PF11988.8 AAS53091.1 - 0.031 13.3 1.7 0.037 13.0 1.7 1.1 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal COG2 PF06148.11 AAS53091.1 - 0.052 13.6 2.6 0.062 13.4 2.6 1.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 JIP_LZII PF16471.5 AAS53091.1 - 0.33 11.1 5.9 0.58 10.4 5.9 1.5 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II OST3_OST6 PF04756.13 AAS53092.2 - 8.8e-81 271.5 0.1 1e-80 271.2 0.1 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Caa3_CtaG PF09678.10 AAS53092.2 - 8.6e-05 22.1 0.7 8.6e-05 22.1 0.7 2.2 2 1 0 2 2 2 1 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) Thioredoxin PF00085.20 AAS53092.2 - 0.00069 19.6 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 AAS53092.2 - 0.15 12.0 0.0 0.34 10.8 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain MKT1_C PF12246.8 AAS53093.2 - 2e-60 204.0 2.4 1e-59 201.7 3.2 1.7 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication MKT1_N PF12247.8 AAS53093.2 - 1.7e-29 102.0 0.1 7.8e-29 99.9 0.2 2.2 2 0 0 2 2 2 1 Temperature dependent protein affecting M2 dsRNA replication XPG_N PF00752.17 AAS53093.2 - 8.3e-20 71.2 0.0 3.4e-19 69.2 0.0 2.1 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 AAS53093.2 - 0.041 14.2 0.0 0.17 12.3 0.0 2.0 1 1 0 1 1 1 0 XPG I-region Cpn60_TCP1 PF00118.24 AAS53094.1 - 1.6e-147 492.1 10.1 1.9e-147 491.9 10.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family EF-hand_4 PF12763.7 AAS53095.2 - 7.8e-52 173.6 0.0 2e-50 169.1 0.1 2.3 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand End3 PF12761.7 AAS53095.2 - 1e-43 149.8 2.7 2.3e-43 148.7 2.7 1.5 1 1 0 1 1 1 1 Actin cytoskeleton-regulatory complex protein END3 EF-hand_1 PF00036.32 AAS53095.2 - 5.3e-05 22.5 0.3 0.00016 21.0 0.3 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 AAS53095.2 - 0.016 15.1 0.2 0.1 12.6 0.2 2.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 AAS53095.2 - 0.024 14.5 0.7 0.055 13.3 0.7 1.6 1 0 0 1 1 1 0 EF-hand domain pair ABC_tran_CTD PF16326.5 AAS53095.2 - 0.027 14.7 1.8 2.8 8.2 0.2 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain Med30 PF11315.8 AAS53095.2 - 0.035 14.3 0.6 0.7 10.1 0.7 2.5 3 0 0 3 3 3 0 Mediator complex subunit 30 FlxA PF14282.6 AAS53095.2 - 0.066 13.2 10.4 0.8 9.7 1.4 2.4 1 1 1 2 2 2 0 FlxA-like protein EF-hand_7 PF13499.6 AAS53095.2 - 0.085 13.3 0.0 1.3 9.5 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain pair Csm1_N PF18504.1 AAS53095.2 - 0.088 13.2 4.7 2.7 8.4 0.3 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain Fib_alpha PF08702.10 AAS53095.2 - 0.11 12.7 3.8 0.18 12.0 3.8 1.4 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family EF-hand_5 PF13202.6 AAS53095.2 - 0.12 12.0 2.1 0.16 11.5 0.2 2.2 3 0 0 3 3 3 0 EF hand DivIC PF04977.15 AAS53095.2 - 0.15 11.9 1.5 4.8 7.0 0.1 2.4 2 0 0 2 2 2 0 Septum formation initiator Lzipper-MIP1 PF14389.6 AAS53095.2 - 0.24 11.7 3.2 3.4 8.0 3.3 2.3 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 SlyX PF04102.12 AAS53095.2 - 0.54 10.9 9.2 1.6 9.4 0.7 2.7 2 0 0 2 2 2 0 SlyX TolA_bind_tri PF16331.5 AAS53095.2 - 2.5 8.2 7.8 9.4 6.4 1.5 2.5 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF4140 PF13600.6 AAS53095.2 - 3.5 8.1 5.3 7.4 7.1 1.7 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SKG6 PF08693.10 AAS53096.1 - 1.8e-14 52.9 0.4 5.2e-14 51.4 0.4 1.9 1 0 0 1 1 1 1 Transmembrane alpha-helix domain He_PIG PF05345.12 AAS53096.1 - 3.4e-09 36.7 7.2 3.9e-07 30.1 0.2 5.1 6 0 0 6 6 4 1 Putative Ig domain TMEM154 PF15102.6 AAS53096.1 - 5.2e-05 23.2 0.6 0.00017 21.5 0.6 1.9 1 0 0 1 1 1 1 TMEM154 protein family Mid2 PF04478.12 AAS53096.1 - 0.0024 17.7 0.2 0.0061 16.4 0.2 1.6 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF2207 PF09972.9 AAS53096.1 - 0.0038 16.1 0.0 0.0062 15.4 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 AAS53096.1 - 0.02 15.8 0.0 0.051 14.5 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF5305 PF17231.2 AAS53096.1 - 0.049 13.0 0.2 0.1 12.0 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Insulin_TMD PF17870.1 AAS53096.1 - 0.13 12.4 0.2 0.25 11.4 0.2 1.4 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment RIFIN PF02009.16 AAS53096.1 - 0.16 11.9 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Rifin Stevor PF17410.2 AAS53096.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Podoplanin PF05808.11 AAS53096.1 - 0.18 11.9 7.8 0.02 15.0 2.8 2.0 2 0 0 2 2 2 0 Podoplanin MGC-24 PF05283.11 AAS53096.1 - 0.61 10.5 9.6 0.034 14.6 2.3 2.4 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Syndecan PF01034.20 AAS53096.1 - 1.3 9.0 3.5 0.48 10.4 0.6 1.7 2 0 0 2 2 1 0 Syndecan domain DUF4834 PF16118.5 AAS53096.1 - 1.6 9.7 5.5 2.5 9.1 0.0 3.5 4 0 0 4 4 3 0 Domain of unknown function (DUF4834) Mucin PF01456.17 AAS53096.1 - 9 6.3 22.5 0.021 14.8 10.8 2.5 3 0 0 3 3 3 0 Mucin-like glycoprotein 4HBT PF03061.22 AAS53097.1 - 1.4e-06 28.6 0.8 0.022 15.1 0.1 2.7 2 1 0 2 2 2 2 Thioesterase superfamily Mito_carr PF00153.27 AAS53098.1 - 2.7e-61 203.5 0.3 1.1e-21 76.5 0.0 3.5 4 0 0 4 4 4 3 Mitochondrial carrier protein EF-hand_7 PF13499.6 AAS53098.1 - 8.8e-13 48.5 0.2 7.6e-10 39.1 0.1 3.1 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS53098.1 - 1.4e-10 40.2 0.0 0.016 15.1 0.0 4.6 4 0 0 4 4 4 3 EF-hand domain EF-hand_1 PF00036.32 AAS53098.1 - 3.1e-10 38.8 0.1 0.11 12.1 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 AAS53098.1 - 7.8e-06 25.2 0.3 1 9.0 0.0 3.5 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 AAS53098.1 - 0.0008 19.2 0.3 0.65 9.9 0.0 3.9 3 1 1 4 4 4 2 EF-hand domain pair HORMA PF02301.18 AAS53099.1 - 7.4e-07 29.0 0.0 9.4e-07 28.6 0.0 1.1 1 0 0 1 1 1 1 HORMA domain Cas_VVA1548 PF09652.10 AAS53099.1 - 0.091 13.0 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative CRISPR-associated protein (Cas_VVA1548) MutL_C PF08676.11 AAS53100.1 - 4.4e-25 88.2 1.9 1.3e-24 86.7 0.0 2.5 3 0 0 3 3 3 1 MutL C terminal dimerisation domain DNA_mis_repair PF01119.19 AAS53100.1 - 9.2e-25 86.6 0.0 2.5e-24 85.2 0.0 1.8 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 AAS53100.1 - 7.1e-12 45.3 0.1 7.1e-12 45.3 0.1 2.1 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AAS53100.1 - 0.0003 21.3 0.0 0.0011 19.5 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S13 PF00416.22 AAS53101.1 - 3.9e-16 59.6 0.0 4.2e-14 53.0 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S13/S18 EOS1 PF12326.8 AAS53102.1 - 4.7e-60 202.5 10.5 4.3e-59 199.3 8.1 2.2 2 0 0 2 2 2 2 N-glycosylation protein Tropomyosin_1 PF12718.7 AAS53103.3 - 4.2e-49 166.4 42.3 5e-49 166.1 42.3 1.0 1 0 0 1 1 1 1 Tropomyosin like Tropomyosin PF00261.20 AAS53103.3 - 2.2e-06 27.3 38.4 0.00055 19.4 12.7 2.0 1 1 1 2 2 2 2 Tropomyosin ATG16 PF08614.11 AAS53103.3 - 4e-05 23.9 38.1 0.007 16.6 16.1 2.0 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 AAS53103.3 - 8.5e-05 22.8 29.6 0.025 14.8 8.7 3.3 1 1 2 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 CLZ PF16526.5 AAS53103.3 - 0.00017 21.9 31.1 0.0084 16.4 1.3 3.8 1 1 3 4 4 4 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels CENP-F_leu_zip PF10473.9 AAS53103.3 - 0.00019 21.5 43.6 0.00035 20.6 7.0 2.6 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 AAS53103.3 - 0.00023 20.6 40.2 0.021 14.2 17.2 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding Cast PF10174.9 AAS53103.3 - 0.00038 18.9 29.4 0.00043 18.7 29.4 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone TMF_DNA_bd PF12329.8 AAS53103.3 - 0.00039 20.4 47.4 0.0049 16.8 22.0 3.2 1 1 2 3 3 3 2 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 AAS53103.3 - 0.00045 19.6 31.9 0.0011 18.4 14.2 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) ADIP PF11559.8 AAS53103.3 - 0.0005 20.2 35.3 0.1 12.7 14.9 2.8 1 1 2 3 3 3 3 Afadin- and alpha -actinin-Binding ZapB PF06005.12 AAS53103.3 - 0.0005 20.5 48.1 0.18 12.2 2.6 4.0 2 1 0 2 2 1 1 Cell division protein ZapB bZIP_1 PF00170.21 AAS53103.3 - 0.00059 19.9 40.3 0.016 15.3 1.1 4.5 1 1 3 4 4 4 1 bZIP transcription factor DUF1664 PF07889.12 AAS53103.3 - 0.00087 19.3 20.4 0.0033 17.5 6.6 2.4 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) Laminin_II PF06009.12 AAS53103.3 - 0.00091 19.3 23.6 0.016 15.2 10.9 2.3 1 1 1 2 2 2 2 Laminin Domain II TMF_TATA_bd PF12325.8 AAS53103.3 - 0.0015 18.7 38.7 0.015 15.5 21.4 3.0 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding Lebercilin PF15619.6 AAS53103.3 - 0.0017 18.1 36.6 0.0023 17.6 36.6 1.3 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DUF4201 PF13870.6 AAS53103.3 - 0.003 17.3 33.9 0.0082 15.9 25.4 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4201) MscS_porin PF12795.7 AAS53103.3 - 0.005 16.4 22.8 0.005 16.4 22.8 2.1 1 1 1 2 2 2 1 Mechanosensitive ion channel porin domain Prefoldin_2 PF01920.20 AAS53103.3 - 0.0066 16.4 43.3 0.029 14.3 2.3 4.0 1 1 3 4 4 4 2 Prefoldin subunit Spc7 PF08317.11 AAS53103.3 - 0.0067 15.3 39.0 1 8.1 39.0 2.1 1 1 0 1 1 1 1 Spc7 kinetochore protein FlaC_arch PF05377.11 AAS53103.3 - 0.0077 16.6 27.2 0.27 11.7 0.2 4.7 1 1 2 4 4 3 2 Flagella accessory protein C (FlaC) KLRAQ PF10205.9 AAS53103.3 - 0.0086 16.3 31.2 0.23 11.7 9.1 2.1 1 1 1 2 2 2 2 Predicted coiled-coil domain-containing protein Uso1_p115_C PF04871.13 AAS53103.3 - 0.01 16.2 41.9 0.13 12.7 16.2 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region APG6_N PF17675.1 AAS53103.3 - 0.011 16.3 49.3 0.65 10.5 23.7 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region PSII_Pbs27 PF13326.6 AAS53103.3 - 0.011 16.0 9.3 0.054 13.8 3.5 2.3 1 1 1 2 2 2 0 Photosystem II Pbs27 TPR_MLP1_2 PF07926.12 AAS53103.3 - 0.012 15.7 43.5 0.7 10.0 14.9 3.2 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein HMMR_C PF15908.5 AAS53103.3 - 0.012 15.9 25.4 0.022 15.0 1.0 3.6 1 1 1 2 2 1 0 Hyaluronan mediated motility receptor C-terminal KIP1 PF07765.12 AAS53103.3 - 0.013 15.6 8.0 0.013 15.6 8.0 3.5 1 1 2 3 3 2 0 KIP1-like protein DUF5595 PF18077.1 AAS53103.3 - 0.015 15.4 10.3 0.015 15.4 10.3 3.3 2 2 1 3 3 3 0 Domain of unknown function (DUF5595) PspA_IM30 PF04012.12 AAS53103.3 - 0.016 14.8 28.1 1.9 8.0 28.1 2.1 1 1 0 1 1 1 0 PspA/IM30 family DUF4200 PF13863.6 AAS53103.3 - 0.017 15.5 39.1 0.19 12.1 15.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) MbeD_MobD PF04899.12 AAS53103.3 - 0.017 15.2 14.0 0.17 12.0 1.7 3.1 1 1 2 3 3 3 0 MbeD/MobD like ERM PF00769.19 AAS53103.3 - 0.018 14.8 39.8 0.18 11.6 30.9 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family IFT57 PF10498.9 AAS53103.3 - 0.027 13.4 31.8 0.064 12.2 31.8 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 XhlA PF10779.9 AAS53103.3 - 0.029 14.5 32.4 0.097 12.9 0.2 3.9 2 1 1 3 3 3 0 Haemolysin XhlA Leu_zip PF15294.6 AAS53103.3 - 0.031 13.8 32.0 0.12 11.9 31.9 1.8 1 1 0 1 1 1 0 Leucine zipper GrpE PF01025.19 AAS53103.3 - 0.032 13.9 3.1 0.032 13.9 3.1 3.5 1 1 1 2 2 1 0 GrpE DHR10 PF18595.1 AAS53103.3 - 0.04 14.0 39.4 0.18 11.8 12.3 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain HetR_C PF18460.1 AAS53103.3 - 0.045 13.7 0.8 0.045 13.7 0.8 3.6 1 1 4 5 5 4 0 Heterocyst differentiation regulator C-terminal Hood domain PI3K_P85_iSH2 PF16454.5 AAS53103.3 - 0.046 13.3 34.2 0.32 10.6 2.0 3.1 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain HOOK PF05622.12 AAS53103.3 - 0.049 11.8 33.6 0.066 11.4 33.6 1.3 1 0 0 1 1 1 0 HOOK protein Sec34 PF04136.15 AAS53103.3 - 0.055 13.4 25.8 0.24 11.3 16.1 2.1 1 1 1 2 2 2 0 Sec34-like family Spc24 PF08286.11 AAS53103.3 - 0.056 13.7 37.4 0.53 10.6 1.3 4.0 1 1 3 4 4 4 0 Spc24 subunit of Ndc80 OmpH PF03938.14 AAS53103.3 - 0.067 13.5 35.0 0.072 13.4 13.1 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) EzrA PF06160.12 AAS53103.3 - 0.071 11.3 33.6 0.13 10.4 12.7 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Filament PF00038.21 AAS53103.3 - 0.073 12.6 32.8 0.11 12.0 13.9 2.0 1 1 1 2 2 2 0 Intermediate filament protein Spectrin PF00435.21 AAS53103.3 - 0.078 13.5 31.6 0.95 10.0 12.9 3.1 1 1 2 3 3 3 0 Spectrin repeat Alpha-2-MRAP_C PF06401.11 AAS53103.3 - 0.079 12.9 31.3 0.11 12.4 31.3 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain KASH_CCD PF14662.6 AAS53103.3 - 0.08 12.8 41.8 0.14 12.0 29.6 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF4686 PF15742.5 AAS53103.3 - 0.083 12.0 39.1 0.16 11.1 39.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) DUF5082 PF16888.5 AAS53103.3 - 0.083 13.2 29.1 4e+02 1.3 28.7 3.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) WXG100 PF06013.12 AAS53103.3 - 0.089 13.0 14.6 6.8 7.0 0.2 4.1 2 1 2 4 4 4 0 Proteins of 100 residues with WXG Swi5 PF07061.11 AAS53103.3 - 0.11 12.6 35.8 0.16 12.1 7.6 4.1 1 1 3 4 4 4 0 Swi5 Mod_r PF07200.13 AAS53103.3 - 0.12 12.5 38.7 0.82 9.8 23.0 2.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein APG17 PF04108.12 AAS53103.3 - 0.13 11.3 24.2 0.52 9.4 10.5 2.9 1 1 1 2 2 2 0 Autophagy protein Apg17 Jnk-SapK_ap_N PF09744.9 AAS53103.3 - 0.14 12.4 43.2 0.38 11.0 28.1 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FPP PF05911.11 AAS53103.3 - 0.15 10.2 38.5 0.4 8.8 19.2 1.7 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Rho_Binding PF08912.11 AAS53103.3 - 0.18 12.6 0.9 0.18 12.6 0.9 4.0 1 1 3 4 4 4 0 Rho Binding Fib_alpha PF08702.10 AAS53103.3 - 0.2 11.8 23.3 0.22 11.7 13.9 2.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4472 PF14739.6 AAS53103.3 - 0.23 12.2 31.9 0.4 11.4 8.8 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) CALCOCO1 PF07888.11 AAS53103.3 - 0.28 10.0 35.3 0.32 9.8 35.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Ax_dynein_light PF10211.9 AAS53103.3 - 0.3 11.0 37.7 0.24 11.3 3.3 3.3 1 1 1 2 2 2 0 Axonemal dynein light chain FliD_C PF07195.12 AAS53103.3 - 0.31 10.4 21.2 0.25 10.7 0.5 3.1 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 C-terminus Lectin_N PF03954.14 AAS53103.3 - 0.33 10.7 21.0 0.85 9.4 10.4 2.7 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF2353 PF09789.9 AAS53103.3 - 0.35 10.2 28.9 0.46 9.8 28.9 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DUF724 PF05266.14 AAS53103.3 - 0.36 10.6 31.5 0.74 9.6 11.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) bZIP_2 PF07716.15 AAS53103.3 - 0.38 10.9 36.6 0.32 11.1 4.6 4.7 3 2 1 4 4 4 0 Basic region leucine zipper SHE3 PF17078.5 AAS53103.3 - 0.41 10.3 32.3 1 9.1 32.2 1.7 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF3287 PF11690.8 AAS53103.3 - 0.48 10.1 11.5 1.8 8.3 0.3 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3287) HA PF03457.14 AAS53103.3 - 0.58 10.5 6.8 9.6 6.6 3.4 2.9 2 1 0 2 2 2 0 Helicase associated domain AAA_13 PF13166.6 AAS53103.3 - 0.59 8.7 29.4 5.4 5.5 29.4 1.9 1 1 0 1 1 1 0 AAA domain DUF3584 PF12128.8 AAS53103.3 - 0.64 7.5 30.2 0.87 7.0 30.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DivIC PF04977.15 AAS53103.3 - 0.69 9.7 37.0 3.2 7.6 5.4 4.3 1 1 3 4 4 4 0 Septum formation initiator Fzo_mitofusin PF04799.13 AAS53103.3 - 0.78 9.3 23.0 0.44 10.1 7.9 2.7 1 1 1 2 2 2 0 fzo-like conserved region MIS13 PF08202.11 AAS53103.3 - 0.83 8.9 29.7 8.9 5.5 7.8 2.2 1 1 1 2 2 2 0 Mis12-Mtw1 protein family Atg14 PF10186.9 AAS53103.3 - 0.87 8.6 32.2 0.42 9.6 22.9 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TACC_C PF05010.14 AAS53103.3 - 0.93 9.2 34.4 0.31 10.8 2.1 2.1 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Fmp27_WPPW PF10359.9 AAS53103.3 - 1.2 7.9 29.6 0.87 8.4 19.4 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF4407 PF14362.6 AAS53103.3 - 1.3 8.4 21.5 3.9 6.7 21.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 AAS53103.3 - 1.3 9.4 33.2 4.5 7.7 32.2 1.9 1 1 0 1 1 1 0 Fez1 TolA_bind_tri PF16331.5 AAS53103.3 - 1.4 9.1 26.2 3.2 7.9 0.4 4.2 2 1 2 4 4 4 0 TolA binding protein trimerisation LPP PF04728.13 AAS53103.3 - 1.4 9.3 13.6 3.3 8.2 0.3 3.8 2 1 2 4 4 3 0 Lipoprotein leucine-zipper DUF812 PF05667.11 AAS53103.3 - 1.7 7.4 37.0 0.63 8.9 21.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) ABC_tran_CTD PF16326.5 AAS53103.3 - 1.8 8.9 43.5 0.4 10.9 6.0 3.7 1 1 2 3 3 3 0 ABC transporter C-terminal domain HAUS6_N PF14661.6 AAS53103.3 - 1.9 8.0 25.3 0.52 9.9 8.6 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus T2SSM PF04612.12 AAS53103.3 - 2 8.4 12.8 0.42 10.6 2.5 3.0 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein M HrpB7 PF09486.10 AAS53103.3 - 2.2 8.7 17.3 40 4.6 8.3 3.5 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) UPF0242 PF06785.11 AAS53103.3 - 2.3 8.3 42.1 25 4.9 14.8 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-K PF11802.8 AAS53103.3 - 2.4 7.7 36.3 1.7 8.2 11.6 2.1 1 1 1 2 2 2 0 Centromere-associated protein K HemX PF04375.14 AAS53103.3 - 2.6 7.3 28.2 3.2 6.9 12.1 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Fungal_TACC PF12709.7 AAS53103.3 - 2.8 8.4 37.1 1.3 9.5 4.7 4.1 2 1 2 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF2203 PF09969.9 AAS53103.3 - 2.9 8.6 22.9 5.5 7.7 1.5 2.9 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) Phage_GP20 PF06810.11 AAS53103.3 - 3 7.7 33.8 4.5 7.1 15.7 2.7 1 1 2 3 3 3 0 Phage minor structural protein GP20 Nup54 PF13874.6 AAS53103.3 - 3.1 7.9 25.1 3.4 7.8 11.1 2.5 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Snapin_Pallidin PF14712.6 AAS53103.3 - 3.3 8.2 26.1 3 8.3 7.4 3.3 1 1 2 3 3 3 0 Snapin/Pallidin TMPIT PF07851.13 AAS53103.3 - 3.4 6.8 28.2 7.3 5.7 19.7 2.0 1 1 1 2 2 2 0 TMPIT-like protein HAUS-augmin3 PF14932.6 AAS53103.3 - 3.4 7.2 36.0 2.8 7.4 11.1 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 YabA PF06156.13 AAS53103.3 - 3.6 8.3 31.5 1.8e+04 -5.9 31.5 3.1 1 1 0 1 1 0 0 Initiation control protein YabA Sec2p PF06428.11 AAS53103.3 - 3.7 7.6 38.0 0.18 11.8 4.7 4.7 1 1 2 4 4 4 0 GDP/GTP exchange factor Sec2p FAA_hydro_N_2 PF18288.1 AAS53103.3 - 3.8 8.0 16.0 3.2 8.3 1.2 3.8 1 1 3 4 4 4 0 Fumarylacetoacetase N-terminal domain 2 Dynamitin PF04912.14 AAS53103.3 - 4.7 6.4 31.8 22 4.2 31.8 1.9 1 1 0 1 1 1 0 Dynamitin Tweety PF04906.13 AAS53103.3 - 4.7 5.8 8.1 5 5.7 6.9 1.7 1 1 0 1 1 1 0 Tweety Seryl_tRNA_N PF02403.22 AAS53103.3 - 4.9 7.4 32.3 11 6.3 0.7 3.1 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain KxDL PF10241.9 AAS53103.3 - 5.5 7.3 26.0 1.7 9.0 6.7 4.0 1 1 3 4 4 4 0 Uncharacterized conserved protein LprI PF07007.12 AAS53103.3 - 5.7 7.7 14.5 0.69 10.6 3.3 3.0 1 1 2 3 3 3 0 Lysozyme inhibitor LprI DASH_Spc19 PF08287.11 AAS53103.3 - 5.7 6.8 32.1 2.9 7.8 0.4 2.9 1 1 2 3 3 3 0 Spc19 BRE1 PF08647.11 AAS53103.3 - 5.8 7.1 38.9 5.4 7.2 20.6 2.9 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase CRT10 PF08728.10 AAS53103.3 - 6.1 4.9 17.0 6.6 4.8 17.0 1.0 1 0 0 1 1 1 0 CRT10 THOC7 PF05615.13 AAS53103.3 - 7.7 6.8 32.2 15 5.9 13.7 2.6 1 1 1 2 2 2 0 Tho complex subunit 7 HIP1_clath_bdg PF16515.5 AAS53103.3 - 7.9 7.2 36.2 15 6.2 2.1 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FapA PF03961.13 AAS53103.3 - 7.9 5.0 33.0 5.2 5.6 9.8 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A GBP_C PF02841.14 AAS53103.3 - 9 5.6 30.3 11 5.3 30.3 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain PLAC9 PF15205.6 AAS53103.3 - 9.7 6.7 6.5 17 5.9 1.0 2.5 2 0 0 2 2 2 0 Placenta-specific protein 9 Cauli_AT PF03233.13 AAS53103.3 - 9.8 6.1 22.5 8.6 6.3 8.8 2.5 1 1 1 2 2 2 0 Aphid transmission protein Peptidase_M1 PF01433.20 AAS53105.1 - 1.4e-50 171.9 0.1 2.1e-50 171.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 AAS53105.1 - 2e-41 142.6 0.2 2.9e-41 142.0 0.2 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_M1_N PF17900.1 AAS53105.1 - 2.4e-29 102.9 0.0 7.5e-29 101.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain TFIIA_gamma_N PF02268.16 AAS53105.1 - 0.046 13.7 0.0 1.9 8.6 0.0 2.5 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain DnaJ_C PF01556.18 AAS53106.1 - 2.1e-27 96.1 0.0 2.8e-27 95.6 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AAS53106.1 - 5.7e-20 71.2 0.2 1.1e-19 70.3 0.2 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AAS53106.1 - 2.6e-08 34.1 23.2 8e-08 32.5 23.2 1.9 1 0 0 1 1 1 1 DnaJ central domain Apolipoprotein PF01442.18 AAS53107.1 - 0.0045 16.9 9.7 0.042 13.7 7.1 2.6 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain Nucleoporin_FG PF13634.6 AAS53107.1 - 0.026 15.3 6.7 0.07 14.0 1.3 3.1 2 1 0 2 2 2 0 Nucleoporin FG repeat region Rootletin PF15035.6 AAS53107.1 - 0.036 14.1 2.0 0.075 13.0 0.5 2.1 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF2057 PF09829.9 AAS53107.1 - 0.31 11.2 5.6 1 9.5 2.6 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) YscO PF07321.12 AAS53107.1 - 2.3 8.1 14.8 0.068 13.1 1.8 2.8 3 0 0 3 3 3 0 Type III secretion protein YscO PMEI PF04043.15 AAS53107.1 - 9.4 6.6 17.2 0.18 12.2 8.3 2.5 2 1 1 3 3 3 0 Plant invertase/pectin methylesterase inhibitor DUF1752 PF08550.10 AAS53108.1 - 2.5e-09 36.8 0.2 5.4e-09 35.7 0.2 1.6 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Brix PF04427.18 AAS53109.2 - 1.2e-31 110.4 0.2 1.5e-31 110.0 0.2 1.1 1 0 0 1 1 1 1 Brix domain CorA PF01544.18 AAS53109.2 - 0.16 11.3 0.1 0.26 10.6 0.1 1.4 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein LSM PF01423.22 AAS53111.2 - 4.6e-19 67.9 0.0 8e-19 67.1 0.0 1.4 1 1 0 1 1 1 1 LSM domain CHZ PF09649.10 AAS53112.1 - 2.1e-18 65.5 2.2 2.1e-18 65.5 2.2 2.6 2 0 0 2 2 2 1 Histone chaperone domain CHZ Ras PF00071.22 AAS53113.2 - 1.9e-60 203.1 0.4 2.3e-60 202.9 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS53113.2 - 9.8e-35 119.4 0.1 1.5e-34 118.7 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS53113.2 - 2.5e-13 49.9 0.0 3.4e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AAS53113.2 - 5.1e-07 29.8 0.1 8.1e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS53113.2 - 6.7e-05 22.5 0.1 0.00027 20.5 0.1 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS53113.2 - 0.00081 19.3 0.2 0.01 15.8 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 AAS53113.2 - 0.00089 18.7 0.0 0.0011 18.3 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AAS53113.2 - 0.0031 17.0 0.0 0.005 16.3 0.0 1.4 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AAS53113.2 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 AAS53113.2 - 0.022 14.5 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 AAS53113.2 - 0.023 15.1 0.1 0.041 14.3 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 AAS53113.2 - 0.036 14.4 0.1 0.082 13.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.14 AAS53113.2 - 0.066 12.4 0.0 0.092 12.0 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain Septin PF00735.18 AAS53113.2 - 0.071 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Septin DUF1128 PF06569.11 AAS53113.2 - 0.073 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1128) AAA_24 PF13479.6 AAS53113.2 - 0.085 12.6 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS53113.2 - 0.1 13.1 0.7 0.15 12.5 0.6 1.6 1 1 0 1 1 1 0 ABC transporter MCM PF00493.23 AAS53113.2 - 0.12 11.4 0.0 0.2 10.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_21 PF13304.6 AAS53113.2 - 0.13 12.0 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system BicD PF09730.9 AAS53115.1 - 0.053 11.9 0.1 0.096 11.1 0.1 1.3 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D zn-ribbon_14 PF16503.5 AAS53116.1 - 8.1e-18 63.6 4.3 8.1e-18 63.6 4.3 3.3 4 0 0 4 4 4 1 Zinc-ribbon ATP_bind_3 PF01171.20 AAS53116.1 - 1.2e-16 61.0 0.0 2.4e-16 60.0 0.0 1.5 1 0 0 1 1 1 1 PP-loop family tRNA_Me_trans PF03054.16 AAS53116.1 - 0.017 13.9 0.0 0.028 13.2 0.0 1.3 1 1 0 1 1 1 0 tRNA methyl transferase PX PF00787.24 AAS53117.2 - 5.1e-13 49.0 0.2 1.2e-12 47.8 0.2 1.6 1 0 0 1 1 1 1 PX domain DUF4559 PF15112.6 AAS53117.2 - 0.13 11.9 8.1 0.027 14.1 2.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4559) ANAPC4_WD40 PF12894.7 AAS53118.1 - 5.7e-09 36.2 0.0 0.00037 20.7 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS53118.1 - 1.1e-07 32.4 25.0 2.1e-05 25.2 0.7 6.4 7 1 0 7 7 7 2 WD domain, G-beta repeat PKD PF00801.20 AAS53118.1 - 0.021 14.6 0.1 0.096 12.5 0.0 2.0 2 0 0 2 2 2 0 PKD domain Cyclin PF08613.11 AAS53119.1 - 0.001 19.5 0.0 0.002 18.5 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 AAS53119.1 - 0.071 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Cyclin, N-terminal domain Kinesin PF00225.23 AAS53120.1 - 1.8e-113 378.9 0.1 2.8e-113 378.2 0.1 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 AAS53120.1 - 1.3e-25 90.1 0.0 3.9e-25 88.5 0.0 1.8 1 0 0 1 1 1 1 Microtubule binding Borrelia_REV PF03978.13 AAS53120.1 - 0.053 13.5 0.5 0.14 12.1 0.5 1.7 1 0 0 1 1 1 0 Borrelia burgdorferi REV protein AAA_16 PF13191.6 AAS53120.1 - 0.11 12.9 0.1 12 6.3 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain COX14 PF14880.6 AAS53122.1 - 3.7e-23 81.1 1.1 3.9e-23 81.0 1.1 1.0 1 0 0 1 1 1 1 Cytochrome oxidase c assembly SHR3_chaperone PF08229.11 AAS53122.1 - 0.074 12.0 0.1 0.078 11.9 0.1 1.0 1 0 0 1 1 1 0 ER membrane protein SH3 MFS_1 PF07690.16 AAS53123.1 - 9.7e-13 47.8 25.5 1.4e-12 47.3 25.5 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF4500 PF14937.6 AAS53123.1 - 0.031 14.3 3.0 0.5 10.4 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4500) Septin PF00735.18 AAS53124.1 - 5.5e-107 357.2 0.6 7.1e-107 356.9 0.0 1.4 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 AAS53124.1 - 5.7e-07 29.6 0.0 1.3e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AAS53124.1 - 2.5e-05 24.4 10.1 0.0047 17.0 0.2 3.1 2 1 1 3 3 3 2 Dynamin family AIG1 PF04548.16 AAS53124.1 - 0.00025 20.5 0.0 0.00025 20.5 0.0 2.0 2 0 0 2 2 2 1 AIG1 family ABC_tran PF00005.27 AAS53124.1 - 0.00037 21.0 1.6 0.0007 20.1 0.0 2.0 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 AAS53124.1 - 0.00078 19.4 1.6 0.00078 19.4 1.6 2.8 3 1 0 3 3 3 1 RsgA GTPase IIGP PF05049.13 AAS53124.1 - 0.002 17.3 0.1 0.0041 16.2 0.1 1.4 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) AAA_22 PF13401.6 AAS53124.1 - 0.032 14.5 0.2 0.11 12.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Macoilin PF09726.9 AAS53124.1 - 0.063 11.8 6.4 0.083 11.4 6.4 1.1 1 0 0 1 1 1 0 Macoilin family Roc PF08477.13 AAS53124.1 - 0.068 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 AAS53124.1 - 0.083 12.6 0.0 0.19 11.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 AAS53124.1 - 0.085 12.4 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain G-alpha PF00503.20 AAS53124.1 - 0.11 11.6 0.1 0.11 11.6 0.1 3.1 4 0 0 4 4 4 0 G-protein alpha subunit PduV-EutP PF10662.9 AAS53124.1 - 0.18 11.5 0.3 4.6 7.0 0.1 2.4 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 AAS53124.1 - 0.33 11.4 12.3 1.5 9.2 7.7 2.5 2 1 0 2 2 2 0 AAA domain Gasdermin_C PF17708.1 AAS53124.1 - 0.77 9.9 6.3 2.6 8.1 3.8 2.2 2 0 0 2 2 2 0 Gasdermin PUB domain IGPS PF00218.21 AAS53125.1 - 4.2e-81 271.8 0.0 5.5e-81 271.5 0.0 1.1 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase GATase PF00117.28 AAS53125.1 - 3.3e-49 167.2 0.0 4.6e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AAS53125.1 - 3.2e-09 36.9 0.4 9.7e-09 35.3 0.4 1.8 1 1 0 1 1 1 1 Peptidase C26 QRPTase_C PF01729.19 AAS53125.1 - 0.012 15.4 0.0 0.14 12.0 0.0 2.5 3 0 0 3 3 3 0 Quinolinate phosphoribosyl transferase, C-terminal domain Peripla_BP_2 PF01497.18 AAS53125.1 - 0.034 13.7 0.0 0.057 13.0 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein NanE PF04131.14 AAS53125.1 - 0.16 11.2 0.0 0.32 10.2 0.0 1.6 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase Syja_N PF02383.18 AAS53126.1 - 4.8e-81 272.6 0.0 6.5e-81 272.1 0.0 1.2 1 0 0 1 1 1 1 SacI homology domain PFU PF09070.11 AAS53127.2 - 1.1e-38 131.9 0.3 2.6e-38 130.8 0.1 1.7 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) PUL PF08324.11 AAS53127.2 - 1.7e-35 122.6 0.2 2.9e-35 121.9 0.2 1.4 1 0 0 1 1 1 1 PUL domain WD40 PF00400.32 AAS53127.2 - 3e-31 107.0 18.7 2e-09 37.9 0.1 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53127.2 - 0.0004 20.6 0.1 0.071 13.4 0.0 3.7 2 2 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 AAS53127.2 - 0.0013 18.8 0.1 4 7.5 0.0 3.8 2 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region FoP_duplication PF13865.6 AAS53128.2 - 7.4e-08 32.8 1.4 7.4e-08 32.8 1.4 2.3 2 0 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 RRM_1 PF00076.22 AAS53128.2 - 0.0037 17.1 0.0 0.011 15.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS53128.2 - 0.12 12.3 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Occluded RNA-recognition motif Mito_carr PF00153.27 AAS53129.1 - 9e-45 150.5 8.1 1.1e-18 66.9 0.2 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein NMT1 PF09084.11 AAS53130.1 - 7.4e-77 258.1 0.0 9.4e-77 257.8 0.0 1.1 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AAS53130.1 - 0.0048 16.5 0.0 0.0074 15.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein NMT1_2 PF13379.6 AAS53130.1 - 0.0054 16.5 0.0 0.099 12.3 0.0 2.3 2 0 0 2 2 2 1 NMT1-like family STAT1_TAZ2bind PF12162.8 AAS53130.1 - 0.065 12.8 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 STAT1 TAZ2 binding domain PBP_like PF12727.7 AAS53130.1 - 0.13 11.4 0.0 0.57 9.3 0.0 1.8 1 1 0 2 2 2 0 PBP superfamily domain Lipase_3 PF01764.25 AAS53131.1 - 1.6e-26 92.9 0.0 2.7e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) tify PF06200.14 AAS53131.1 - 0.042 13.2 0.0 0.12 11.7 0.0 1.7 1 0 0 1 1 1 0 tify domain Lipase_3 PF01764.25 AAS53132.1 - 5.7e-20 71.6 0.0 8.6e-20 71.1 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AAS53132.1 - 0.00062 19.1 0.1 0.0012 18.1 0.0 1.4 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 AAS53133.1 - 7.8e-28 97.1 0.0 1.2e-27 96.5 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 AAS53133.1 - 8.1e-05 22.0 0.0 0.00013 21.3 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 DUF2974 PF11187.8 AAS53133.1 - 0.056 13.0 0.2 2 7.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 AAS53133.1 - 0.12 13.0 0.1 0.18 12.4 0.1 1.3 1 1 0 1 1 1 0 Alpha/beta hydrolase family DUF3089 PF11288.8 AAS53133.1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) PaaX_C PF08223.11 AAS53134.1 - 0.063 13.6 0.1 0.091 13.0 0.1 1.3 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Arnt_C PF18583.1 AAS53134.1 - 0.14 11.8 0.3 0.24 11.0 0.3 1.4 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain Homeodomain PF00046.29 AAS53135.2 - 2.2e-16 59.4 2.0 2.9e-16 59.1 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AAS53135.2 - 3.3e-06 26.9 0.8 5.7e-06 26.1 0.3 1.7 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 AAS53135.2 - 0.033 14.1 0.0 0.064 13.1 0.0 1.5 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT SUI1 PF01253.22 AAS53136.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AAS53136.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) NAP PF00956.18 AAS53137.2 - 8.7e-05 21.8 0.2 0.0067 15.6 0.0 2.7 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) HSP20 PF00011.21 AAS53138.1 - 1.4e-20 73.3 0.5 1.8e-20 73.0 0.5 1.1 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AAS53138.1 - 1.3e-06 27.8 0.0 1.9e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA Mannosyl_trans3 PF11051.8 AAS53139.2 - 1.6e-72 244.2 0.1 2.3e-72 243.7 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyco_transf_8 PF01501.20 AAS53139.2 - 0.0045 16.6 0.8 0.0081 15.7 0.3 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 8 TPPK_C PF12555.8 AAS53140.1 - 5.2 7.2 16.4 0.79 9.8 0.7 3.0 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal SNARE PF05739.19 AAS53142.2 - 1.3e-12 47.5 0.4 2.8e-12 46.4 0.4 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 AAS53142.2 - 2.6e-05 24.5 13.2 0.0024 18.2 2.0 2.7 2 1 0 2 2 2 2 Syntaxin-like protein Synaptobrevin PF00957.21 AAS53142.2 - 0.00024 20.9 0.6 0.00047 19.9 0.6 1.5 1 0 0 1 1 1 1 Synaptobrevin Prominin PF05478.11 AAS53142.2 - 0.00063 17.9 1.6 0.001 17.1 1.6 1.3 1 0 0 1 1 1 1 Prominin Rx_N PF18052.1 AAS53142.2 - 0.0023 18.2 0.2 0.019 15.2 0.0 2.3 2 0 0 2 2 2 1 Rx N-terminal domain Noelin-1 PF12308.8 AAS53142.2 - 0.0037 17.2 3.1 0.46 10.5 1.6 2.3 2 0 0 2 2 2 1 Neurogenesis glycoprotein LPP PF04728.13 AAS53142.2 - 0.0038 17.6 4.1 0.95 9.9 0.1 3.2 2 1 1 3 3 3 1 Lipoprotein leucine-zipper Herpes_UL6 PF01763.16 AAS53142.2 - 0.0047 15.5 1.5 0.41 9.1 2.0 2.0 2 0 0 2 2 2 1 Herpesvirus UL6 like DUF5345 PF17280.2 AAS53142.2 - 0.0083 16.1 0.0 0.036 14.1 0.0 2.0 2 0 0 2 2 2 1 Family of unknown function (DUF5345) Occludin_ELL PF07303.13 AAS53142.2 - 0.02 15.6 2.2 0.065 14.0 0.1 2.3 2 1 0 2 2 2 0 Occludin homology domain Baculo_PEP_C PF04513.12 AAS53142.2 - 0.033 14.2 6.1 0.06 13.4 2.7 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Vac7 PF12751.7 AAS53142.2 - 0.052 13.0 1.0 2.2 7.7 0.1 2.1 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Spc7 PF08317.11 AAS53142.2 - 0.06 12.2 7.1 0.03 13.2 3.3 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein MCU PF04678.13 AAS53142.2 - 0.2 11.7 1.4 0.42 10.7 0.8 1.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Laminin_II PF06009.12 AAS53142.2 - 0.26 11.3 4.2 0.64 10.0 1.9 2.2 2 0 0 2 2 2 0 Laminin Domain II DASH_Duo1 PF08651.10 AAS53142.2 - 0.33 10.7 4.8 3.8 7.3 0.1 3.1 2 1 1 3 3 3 0 DASH complex subunit Duo1 NPV_P10 PF05531.12 AAS53142.2 - 0.65 10.5 7.1 2.2 8.8 2.4 2.8 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 AAS53142.2 - 0.71 9.9 3.6 1.2 9.2 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 AAS53142.2 - 0.92 10.0 6.7 1.4 9.5 4.6 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 Syntaxin PF00804.25 AAS53142.2 - 1.1 8.9 8.4 0.093 12.4 2.4 2.1 3 0 0 3 3 3 0 Syntaxin FliJ PF02050.16 AAS53142.2 - 3.2 8.0 13.0 11 6.2 7.9 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein Mod_r PF07200.13 AAS53142.2 - 3.7 7.6 7.7 3 8.0 0.7 2.9 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DHR10 PF18595.1 AAS53142.2 - 7.3 6.7 9.5 1.2 9.3 0.8 2.7 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain bZIP_2 PF07716.15 AAS53143.1 - 0.0028 17.7 6.8 0.0077 16.3 6.8 1.7 1 0 0 1 1 1 1 Basic region leucine zipper DUF5401 PF17380.2 AAS53143.1 - 0.011 13.9 2.8 0.018 13.2 2.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) MRF_C1 PF13887.6 AAS53143.1 - 0.064 12.4 0.4 0.12 11.6 0.4 1.4 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 PspB PF06667.12 AAS53143.1 - 0.29 11.2 2.5 0.62 10.2 2.5 1.4 1 0 0 1 1 1 0 Phage shock protein B bZIP_1 PF00170.21 AAS53143.1 - 0.41 10.8 6.2 0.86 9.7 6.2 1.4 1 0 0 1 1 1 0 bZIP transcription factor YabA PF06156.13 AAS53143.1 - 0.79 10.4 3.7 2 9.1 3.7 1.6 1 0 0 1 1 1 0 Initiation control protein YabA RGS PF00615.19 AAS53144.1 - 1.9e-12 47.5 0.0 2.9e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Chorion_2 PF03964.15 AAS53144.1 - 0.038 14.8 0.7 0.038 14.8 0.7 2.0 2 0 0 2 2 2 0 Chorion family 2 HMGL-like PF00682.19 AAS53145.2 - 8.1e-88 294.4 0.0 6e-87 291.5 0.0 2.1 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 AAS53145.2 - 3.8e-24 85.1 0.0 7e-24 84.2 0.0 1.5 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Syja_N PF02383.18 AAS53146.2 - 4.6e-76 256.2 0.5 9.2e-76 255.2 0.5 1.5 2 0 0 2 2 2 1 SacI homology domain Exo_endo_phos PF03372.23 AAS53146.2 - 6.2e-14 52.1 0.0 9.7e-14 51.4 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family YEATS PF03366.16 AAS53147.1 - 5.7e-36 122.4 0.9 9.2e-36 121.7 0.9 1.3 1 0 0 1 1 1 1 YEATS family DUF465 PF04325.13 AAS53147.1 - 0.022 14.8 1.5 0.044 13.8 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF465) Osmo_CC PF08946.10 AAS53147.1 - 0.25 11.6 6.0 0.58 10.4 6.0 1.6 1 0 0 1 1 1 0 Osmosensory transporter coiled coil TFIIIC_sub6 PF10419.9 AAS53148.1 - 3.7e-23 81.2 0.1 6.4e-23 80.4 0.1 1.3 1 0 0 1 1 1 1 TFIIIC subunit triple barrel domain His_Phos_1 PF00300.22 AAS53148.1 - 5.2e-18 65.4 0.0 1.2e-17 64.2 0.0 1.6 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Maf PF02545.14 AAS53149.1 - 6.4e-36 123.7 0.0 7.4e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein RRM_1 PF00076.22 AAS53150.1 - 1.9e-17 62.8 0.0 3.5e-17 62.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AAS53150.1 - 0.054 13.1 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AAS53150.1 - 0.071 13.1 0.0 0.13 12.3 0.0 1.3 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 AAS53150.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.7 1 0 0 1 1 1 0 Limkain b1 Cyt-b5 PF00173.28 AAS53151.1 - 8.8e-26 89.9 0.0 1.3e-25 89.3 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Vac14_Fab1_bd PF12755.7 AAS53152.1 - 0.00036 21.1 0.3 2.7 8.6 0.0 3.5 2 1 1 3 3 3 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 AAS53152.1 - 0.00042 20.4 4.0 0.22 11.5 0.1 2.7 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 AAS53152.1 - 0.0022 18.1 0.0 9.6 6.8 0.0 4.3 4 0 0 4 4 4 1 HEAT repeat DFF-C PF09033.10 AAS53152.1 - 0.0025 17.8 0.1 0.0058 16.5 0.1 1.6 1 0 0 1 1 1 1 DNA Fragmentation factor 45kDa, C terminal domain CLASP_N PF12348.8 AAS53152.1 - 0.0049 16.5 0.2 0.014 14.9 0.2 1.8 1 1 1 2 2 2 1 CLASP N terminal Adaptin_N PF01602.20 AAS53152.1 - 0.15 10.6 7.1 0.31 9.5 2.1 2.5 2 1 1 3 3 3 0 Adaptin N terminal region DEAD PF00270.29 AAS53153.2 - 3.5e-49 167.0 0.0 1.2e-48 165.2 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53153.2 - 1.2e-33 115.8 0.0 4e-32 110.8 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53153.2 - 0.0004 20.4 0.0 0.00078 19.5 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 AAS53153.2 - 0.013 14.4 0.2 0.39 9.4 0.0 2.6 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 AAS53153.2 - 0.026 14.9 0.0 4.4 7.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain ERCC3_RAD25_C PF16203.5 AAS53153.2 - 0.051 12.8 0.0 0.081 12.1 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase RNA_pol_L_2 PF13656.6 AAS53154.2 - 2.3e-34 117.0 0.0 3e-34 116.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 AAS53154.2 - 1.8e-15 56.1 0.0 2.6e-15 55.6 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain HMG_box PF00505.19 AAS53155.1 - 1.3e-32 112.0 2.0 5.7e-17 61.9 0.0 2.2 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS53155.1 - 2.7e-20 72.7 0.1 7.5e-10 39.3 0.6 2.2 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.12 AAS53155.1 - 3.9e-09 36.3 0.2 0.00035 20.5 0.0 3.2 3 0 0 3 3 3 2 CHDNT (NUC034) domain Ccdc124 PF06244.12 AAS53155.1 - 0.06 13.9 0.1 2 9.0 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 124 /Oxs1 COX4 PF02936.14 AAS53155.1 - 0.24 11.4 0.2 0.24 11.4 0.2 1.7 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV TrkH PF02386.16 AAS53156.2 - 7.4e-161 536.0 6.6 7.4e-161 536.0 6.6 2.1 2 0 0 2 2 2 2 Cation transport protein Pkinase PF00069.25 AAS53157.1 - 8.7e-60 202.3 0.0 1.1e-59 201.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53157.1 - 2.8e-37 128.4 0.0 3.8e-37 128.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53157.1 - 0.00012 21.5 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 AAS53157.1 - 0.0021 17.2 0.0 0.0034 16.5 0.0 1.2 1 0 0 1 1 1 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 AAS53157.1 - 0.065 12.0 0.0 0.12 11.1 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase Pro_isomerase PF00160.21 AAS53157.1 - 0.28 11.4 1.8 1.2 9.4 0.1 2.4 3 0 0 3 3 3 0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF5310 PF17237.2 AAS53158.1 - 1.1e-17 63.6 0.6 1.2e-17 63.5 0.6 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5310) zf-H2C2 PF09337.10 AAS53159.1 - 4.3e-15 55.6 2.4 8.2e-15 54.8 2.4 1.5 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 AAS53159.1 - 3.1e-11 43.2 0.3 7.5e-11 42.0 0.3 1.7 1 0 0 1 1 1 1 Integrase zinc binding domain Acetyltransf_1 PF00583.25 AAS53159.1 - 6.4e-06 26.4 0.0 2.3e-05 24.6 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 AAS53159.1 - 0.026 15.2 0.0 0.066 13.9 0.0 1.8 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AAS53159.1 - 0.14 12.3 0.1 0.46 10.6 0.0 1.8 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase GCD14 PF08704.10 AAS53160.1 - 5.6e-83 278.4 0.0 4.6e-82 275.4 0.0 2.0 1 1 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 AAS53160.1 - 1.7e-05 24.6 0.0 5.5e-05 22.9 0.0 2.0 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Gcd10p PF04189.13 AAS53160.1 - 0.0048 16.1 0.0 0.012 14.7 0.0 1.6 2 0 0 2 2 2 1 Gcd10p family RrnaAD PF00398.20 AAS53160.1 - 0.0061 15.7 0.0 0.019 14.0 0.0 1.7 2 0 0 2 2 2 1 Ribosomal RNA adenine dimethylase PCMT PF01135.19 AAS53160.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 AAS53160.1 - 0.099 12.4 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Acyl-CoA_dh_1 PF00441.24 AAS53161.1 - 1.3e-19 70.9 0.0 2.1e-19 70.2 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 AAS53161.1 - 7.3e-11 42.1 0.0 1.8e-10 40.9 0.0 1.7 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 AAS53161.1 - 0.00031 21.4 0.0 0.00055 20.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 AAS53161.1 - 0.046 14.0 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain LSM PF01423.22 AAS53162.1 - 2.6e-15 55.8 0.1 4.3e-15 55.1 0.1 1.3 1 0 0 1 1 1 1 LSM domain PUF PF00806.19 AAS53162.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Pumilio-family RNA binding repeat Kazal_3 PF18434.1 AAS53162.1 - 0.2 11.4 0.2 0.35 10.7 0.2 1.4 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF1687 PF07955.11 AAS53163.1 - 3.2e-20 72.9 0.0 4.4e-20 72.5 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1687) DUF5427 PF10310.9 AAS53164.2 - 3.2e-100 336.3 2.4 3.8e-100 336.1 2.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5427) Alb1 PF09135.11 AAS53165.1 - 7.2e-17 62.2 6.4 7.2e-17 62.2 6.4 1.5 1 1 0 1 1 1 1 Alb1 RGI1 PF10843.8 AAS53165.1 - 0.07 12.8 0.9 0.6 9.7 0.0 2.1 2 0 0 2 2 2 0 Respiratory growth induced protein 1 DUF5564 PF17719.1 AAS53165.1 - 0.093 12.9 3.3 0.15 12.2 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5564) Ribul_P_3_epim PF00834.19 AAS53166.1 - 1.3e-67 227.0 0.0 1.7e-67 226.6 0.0 1.1 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Sugar_tr PF00083.24 AAS53167.1 - 4.6e-170 566.4 27.9 5.2e-170 566.2 27.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53167.1 - 1.3e-35 122.9 39.9 1.2e-28 100.1 15.1 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1772 PF08592.11 AAS53167.1 - 0.0099 16.2 15.6 0.098 13.0 0.0 3.9 3 1 0 4 4 4 2 Domain of unknown function (DUF1772) DUF3792 PF12670.7 AAS53167.1 - 0.16 12.1 0.2 0.16 12.1 0.2 5.0 4 1 0 4 4 4 0 Protein of unknown function (DUF3792) tRNA-synt_1d PF00750.19 AAS53168.1 - 5.1e-121 403.9 6.2 6.2e-121 403.6 6.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (R) DALR_1 PF05746.15 AAS53168.1 - 7.8e-30 103.5 0.3 2.8e-28 98.5 0.1 2.6 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.16 AAS53168.1 - 1.9e-06 28.3 0.0 6.2e-06 26.7 0.0 2.0 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain DUF4393 PF14337.6 AAS53168.1 - 0.029 14.2 1.1 0.59 9.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4393) Cdd1 PF11731.8 AAS53168.1 - 0.11 12.7 0.0 19 5.6 0.0 2.7 2 0 0 2 2 2 0 Pathogenicity locus Sugar_tr PF00083.24 AAS53169.1 - 3.5e-172 573.3 25.9 4.1e-172 573.1 25.9 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53169.1 - 9.3e-31 107.0 25.1 9.6e-30 103.7 19.6 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS53170.1 - 3.2e-160 533.9 26.6 3.7e-160 533.7 26.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53170.1 - 2.7e-33 115.4 46.8 8.6e-29 100.6 23.9 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Rnf-Nqr PF02508.14 AAS53170.1 - 0.0019 18.2 0.6 0.0019 18.2 0.6 2.8 3 0 0 3 3 3 1 Rnf-Nqr subunit, membrane protein OATP PF03137.20 AAS53170.1 - 1.5 7.1 22.3 0.18 10.1 0.5 4.1 1 1 2 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family Svf1_C PF17187.4 AAS53171.1 - 5.7e-63 211.7 0.4 1e-62 210.8 0.4 1.4 1 0 0 1 1 1 1 Svf1-like C-terminal lipocalin-like domain Svf1 PF08622.10 AAS53171.1 - 5.1e-60 202.2 0.1 9.2e-60 201.4 0.1 1.4 1 0 0 1 1 1 1 Svf1-like N-terminal lipocalin domain Homeodomain PF00046.29 AAS53172.2 - 6.2e-20 70.8 2.7 1.2e-19 69.9 2.7 1.5 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AAS53172.2 - 0.00096 19.0 1.4 0.0025 17.7 1.4 1.7 1 0 0 1 1 1 1 Homeobox KN domain Aldedh PF00171.22 AAS53173.1 - 2.7e-168 560.2 0.0 3.1e-168 560.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Mg_chelatase_C PF13335.6 AAS53173.1 - 0.073 13.7 0.7 0.073 13.7 0.7 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal YCII PF03795.14 AAS53173.1 - 0.33 11.4 2.1 12 6.4 0.2 3.3 2 1 1 3 3 3 0 YCII-related domain Cep3 PF16846.5 AAS53174.1 - 6.3e-204 678.2 20.4 7.2e-204 678.0 20.4 1.0 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Zn_clus PF00172.18 AAS53174.1 - 6.4e-06 26.2 10.5 1.1e-05 25.5 10.5 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PV-1 PF06637.11 AAS53174.1 - 0.055 12.3 0.1 0.094 11.5 0.1 1.3 1 0 0 1 1 1 0 PV-1 protein (PLVAP) Mlh1_C PF16413.5 AAS53175.1 - 8.2e-84 281.2 0.1 1.3e-83 280.5 0.1 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 AAS53175.1 - 3.3e-32 110.7 0.2 1e-31 109.1 0.0 2.0 2 0 0 2 2 2 1 DNA mismatch repair protein, C-terminal domain HATPase_c_3 PF13589.6 AAS53175.1 - 1.4e-11 44.4 0.1 4.5e-11 42.7 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AAS53175.1 - 1.2e-06 29.0 0.1 4.5e-06 27.1 0.0 2.0 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Nse4_C PF08743.10 AAS53176.1 - 1.8e-29 101.8 0.0 4.1e-29 100.7 0.0 1.6 1 0 0 1 1 1 1 Nse4 C-terminal Nse4-Nse3_bdg PF15412.6 AAS53176.1 - 3.9e-13 49.3 0.0 8.6e-13 48.2 0.0 1.5 1 0 0 1 1 1 1 Binding domain of Nse4/EID3 to Nse3-MAGE Peptidase_M22 PF00814.25 AAS53177.1 - 1.8e-61 208.3 0.0 2.2e-61 207.9 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Mito_carr PF00153.27 AAS53178.1 - 8.5e-64 211.5 1.2 4.8e-22 77.7 0.1 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein LNS2 PF08235.13 AAS53179.1 - 3.4e-97 324.4 0.0 4.6e-97 323.9 0.0 1.2 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 AAS53179.1 - 1.4e-42 143.8 0.0 2.5e-42 143.0 0.0 1.5 1 0 0 1 1 1 1 lipin, N-terminal conserved region Acid_phosphat_B PF03767.14 AAS53179.1 - 0.0069 16.0 0.5 0.035 13.7 0.0 2.2 3 0 0 3 3 3 1 HAD superfamily, subfamily IIIB (Acid phosphatase) WRNPLPNID PF15017.6 AAS53179.1 - 0.0081 17.0 0.3 0.0081 17.0 0.3 2.5 2 0 0 2 2 2 1 Putative WW-binding domain and destruction box Hydrolase_6 PF13344.6 AAS53179.1 - 0.08 13.1 0.0 0.43 10.7 0.0 2.1 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase LisH PF08513.11 AAS53180.2 - 1.4e-06 28.0 0.3 2.3e-06 27.3 0.3 1.4 1 0 0 1 1 1 1 LisH Vezatin PF12632.7 AAS53181.1 - 1.8e-05 24.3 4.1 6.4e-05 22.5 4.1 1.9 1 1 0 1 1 1 1 Mysoin-binding motif of peroxisomes SesA PF17107.5 AAS53181.1 - 0.0032 17.6 0.3 0.0075 16.5 0.3 1.5 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Img2 PF05046.14 AAS53181.1 - 0.11 12.8 0.1 0.25 11.7 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) UDPGP PF01704.18 AAS53182.1 - 1.6e-52 178.5 0.0 2.1e-52 178.2 0.0 1.0 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase NTP_transf_3 PF12804.7 AAS53182.1 - 0.016 15.6 0.1 0.044 14.1 0.1 2.1 1 1 0 1 1 1 0 MobA-like NTP transferase domain PhoLip_ATPase_C PF16212.5 AAS53183.1 - 3e-69 233.5 23.4 3e-69 233.5 23.4 2.0 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AAS53183.1 - 1e-19 70.0 5.9 6.4e-19 67.4 0.3 2.7 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Hydrolase PF00702.26 AAS53183.1 - 1.3e-13 51.7 0.5 3e-06 27.7 0.0 4.1 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS53183.1 - 5.6e-11 42.4 0.0 3.8e-10 39.7 0.0 2.3 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 AAS53183.1 - 1.5e-08 34.4 0.0 1.1e-07 31.5 0.0 2.4 1 1 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AAS53183.1 - 0.0034 17.2 0.6 0.012 15.4 0.6 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DnaJ PF00226.31 AAS53184.1 - 1.9e-24 85.6 2.0 3.1e-24 84.9 2.0 1.4 1 0 0 1 1 1 1 DnaJ domain DNA_pol_B PF00136.21 AAS53185.2 - 6.2e-144 480.1 1.8 8.4e-144 479.7 1.8 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AAS53185.2 - 1.7e-84 283.8 0.0 3.3e-84 282.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 AAS53185.2 - 2.4e-17 63.1 6.8 5.5e-17 62.0 6.8 1.6 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_B_2 PF03175.13 AAS53185.2 - 1.3e-05 24.3 1.3 0.00083 18.3 0.0 2.5 2 0 0 2 2 2 2 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 AAS53185.2 - 0.0031 17.2 0.0 0.0065 16.2 0.0 1.5 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Pkinase PF00069.25 AAS53186.2 - 4.6e-68 229.5 0.0 5.8e-68 229.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53186.2 - 1.7e-35 122.6 0.0 2.3e-35 122.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase FHA PF00498.26 AAS53186.2 - 2.2e-17 63.2 0.5 4.6e-17 62.1 0.5 1.6 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 AAS53186.2 - 3.5e-07 30.4 0.0 9.1e-07 29.1 0.0 1.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain Pkinase_fungal PF17667.1 AAS53186.2 - 4.9e-06 25.6 0.0 7e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 AAS53186.2 - 7e-05 22.3 0.1 0.0001 21.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 AAS53186.2 - 0.0052 16.3 0.9 0.017 14.7 0.9 1.7 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 AAS53186.2 - 0.028 14.1 0.8 1.1 8.8 0.1 2.2 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 AAS53186.2 - 0.1 12.2 0.4 0.32 10.6 0.4 1.8 1 1 0 1 1 1 0 RIO1 family Hepatitis_core PF00906.20 AAS53187.1 - 0.029 13.9 0.0 0.069 12.7 0.0 1.5 1 0 0 1 1 1 0 Hepatitis core antigen DUF1947 PF09183.10 AAS53187.1 - 0.055 13.8 1.9 0.11 12.8 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1947) ATG16 PF08614.11 AAS53188.1 - 1.8e-11 44.7 12.2 3.6e-11 43.7 8.7 2.0 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 AAS53188.1 - 2.8e-05 24.7 2.0 3.7e-05 24.3 2.0 1.1 1 0 0 1 1 1 1 Fez1 TMF_TATA_bd PF12325.8 AAS53188.1 - 0.0019 18.4 2.0 0.0027 17.9 2.0 1.3 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding UPF0242 PF06785.11 AAS53188.1 - 0.0026 17.9 2.8 0.003 17.7 2.8 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus HIP1_clath_bdg PF16515.5 AAS53188.1 - 0.0034 18.0 4.3 0.0039 17.8 1.2 2.2 1 1 1 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 GAS PF13851.6 AAS53188.1 - 0.013 14.9 5.3 0.019 14.3 5.3 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 AAS53188.1 - 0.018 15.2 3.0 1.1 9.4 0.6 2.4 2 0 0 2 2 2 0 bZIP transcription factor Macoilin PF09726.9 AAS53188.1 - 0.028 13.0 1.3 0.028 13.0 1.3 1.0 1 0 0 1 1 1 0 Macoilin family KLRAQ PF10205.9 AAS53188.1 - 0.029 14.6 3.6 0.076 13.3 3.6 1.7 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein FapA PF03961.13 AAS53188.1 - 0.19 10.3 2.7 0.22 10.1 2.7 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 AAS53188.1 - 0.63 10.3 6.6 9.1 6.6 6.6 2.4 1 1 0 1 1 1 0 ABC transporter C-terminal domain APG6_N PF17675.1 AAS53188.1 - 0.93 10.0 8.8 1.5 9.4 8.8 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region Bap31_Bap29_C PF18035.1 AAS53188.1 - 8.3 6.5 9.4 6.4e+02 0.5 9.0 3.0 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain PFK PF00365.20 AAS53189.2 - 1.9e-182 604.9 2.3 1.6e-100 336.1 1.2 2.1 2 0 0 2 2 2 2 Phosphofructokinase Inp1 PF12634.7 AAS53190.2 - 1.6e-26 92.9 0.0 3e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 Inheritance of peroxisomes protein 1 Porin_3 PF01459.22 AAS53191.1 - 2.1e-88 296.3 0.2 2.4e-88 296.1 0.2 1.0 1 0 0 1 1 1 1 Eukaryotic porin Med9 PF07544.13 AAS53192.1 - 4.3e-22 78.0 0.0 5.5e-22 77.7 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase II transcription mediator complex subunit 9 TACC_C PF05010.14 AAS53192.1 - 0.017 14.9 0.0 0.022 14.6 0.0 1.0 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ERG2_Sigma1R PF04622.12 AAS53193.1 - 1.2e-93 312.3 0.2 1.4e-93 312.0 0.2 1.0 1 0 0 1 1 1 1 ERG2 and Sigma1 receptor like protein Longin PF13774.6 AAS53193.1 - 0.14 12.2 0.0 0.88 9.7 0.0 2.0 2 0 0 2 2 2 0 Regulated-SNARE-like domain Whi5 PF08528.11 AAS53194.2 - 2.3e-10 39.8 1.8 3.9e-10 39.1 1.8 1.4 1 0 0 1 1 1 1 Whi5 like FLYWCH PF04500.16 AAS53194.2 - 0.087 13.0 0.1 0.14 12.3 0.1 1.3 1 0 0 1 1 1 0 FLYWCH zinc finger domain LCAT PF02450.15 AAS53195.1 - 4.8e-127 424.4 0.0 6.4e-127 423.9 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase DUF1749 PF08538.10 AAS53195.1 - 0.16 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Autophagy_N PF03986.13 AAS53196.2 - 1.9e-40 138.0 0.1 3.4e-40 137.1 0.1 1.4 1 0 0 1 1 1 1 Autophagocytosis associated protein (Atg3), N-terminal domain Autophagy_C PF10381.9 AAS53196.2 - 4.1e-15 55.0 1.0 4.1e-15 55.0 1.0 1.7 2 0 0 2 2 2 1 Autophagocytosis associated protein C-terminal Autophagy_act_C PF03987.15 AAS53196.2 - 5e-15 55.8 0.1 1.6e-14 54.2 0.0 1.9 2 0 0 2 2 2 1 Autophagocytosis associated protein, active-site domain DUF3664 PF12406.8 AAS53196.2 - 0.061 14.0 3.2 1.1 9.9 0.1 3.0 3 0 0 3 3 3 0 Surface protein XPA_C PF05181.12 AAS53197.2 - 2.8e-21 75.2 0.1 5.1e-21 74.4 0.1 1.5 1 0 0 1 1 1 1 XPA protein C-terminus XPA_N PF01286.18 AAS53197.2 - 2.3 8.3 5.0 0.51 10.4 1.0 2.0 2 0 0 2 2 2 0 XPA protein N-terminal Syntaxin_2 PF14523.6 AAS53197.2 - 8 6.9 10.2 0.84 10.0 3.2 2.5 2 1 0 2 2 2 0 Syntaxin-like protein VHS PF00790.19 AAS53198.1 - 2.9e-37 127.6 0.1 6.2e-37 126.6 0.1 1.5 1 0 0 1 1 1 1 VHS domain FYVE PF01363.21 AAS53198.1 - 1.8e-19 69.6 3.2 1.8e-19 69.6 3.2 2.2 2 0 0 2 2 2 1 FYVE zinc finger UIM PF02809.20 AAS53198.1 - 0.00022 20.9 2.2 0.00022 20.9 2.2 3.7 4 0 0 4 4 4 1 Ubiquitin interaction motif FYVE_2 PF02318.16 AAS53198.1 - 0.00035 20.8 1.6 0.00035 20.8 1.6 2.4 3 0 0 3 3 3 1 FYVE-type zinc finger DUF4375 PF14300.6 AAS53198.1 - 0.14 12.4 0.2 2.1 8.6 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4375) Rot1 PF10681.9 AAS53199.2 - 1e-90 302.9 0.0 1.2e-90 302.6 0.0 1.0 1 0 0 1 1 1 1 Chaperone for protein-folding within the ER, fungal Cyclin_N PF00134.23 AAS53200.1 - 5.5e-41 139.3 0.0 1.1e-40 138.3 0.0 1.5 1 0 0 1 1 1 1 Cyclin, N-terminal domain 40S_S4_C PF16121.5 AAS53201.2 - 0.18 11.5 0.1 0.42 10.3 0.1 1.6 1 0 0 1 1 1 0 40S ribosomal protein S4 C-terminus BBP1_C PF15272.6 AAS53202.2 - 1.2e-32 113.3 23.1 2.5e-31 109.0 23.1 2.1 1 1 0 1 1 1 1 Spindle pole body component BBP1, C-terminal BBP1_N PF15271.6 AAS53202.2 - 1.5e-19 71.3 0.3 2.4e-17 64.1 0.0 2.9 2 1 0 2 2 2 1 Spindle pole body component BBP1, Mps2-binding protein SpoIISA_toxin PF14171.6 AAS53202.2 - 4.5 6.9 7.4 1 9.0 1.1 2.0 1 1 1 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system SAGA-Tad1 PF12767.7 AAS53203.2 - 1.2e-76 257.5 0.4 1.7e-76 257.0 0.1 1.4 2 0 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit TAF4 PF05236.14 AAS53203.2 - 0.00026 20.8 0.0 0.00067 19.5 0.0 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Microtub_bd PF16796.5 AAS53204.1 - 6.8e-23 81.3 0.5 6.8e-23 81.3 0.5 2.5 3 0 0 3 3 3 1 Microtubule binding DUF4201 PF13870.6 AAS53204.1 - 0.005 16.6 9.7 0.005 16.6 9.7 3.5 2 1 1 3 3 3 1 Domain of unknown function (DUF4201) ERM PF00769.19 AAS53204.1 - 0.0075 16.1 16.7 0.0075 16.1 16.7 3.3 1 1 1 2 2 2 1 Ezrin/radixin/moesin family T3SSipB PF16535.5 AAS53204.1 - 0.042 14.3 1.3 0.042 14.3 1.3 2.8 3 0 0 3 3 3 0 Type III cell invasion protein SipB Nbl1_Borealin_N PF10444.9 AAS53204.1 - 0.049 13.3 7.9 0.56 9.9 0.4 3.9 2 1 1 3 3 3 0 Nbl1 / Borealin N terminal Ribosomal_L27A PF00828.19 AAS53204.1 - 0.43 11.3 1.8 1.7 9.4 1.8 2.0 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Filament PF00038.21 AAS53204.1 - 3.7 7.1 45.8 0.29 10.7 10.1 2.3 1 1 1 2 2 2 0 Intermediate filament protein Baculo_PEP_C PF04513.12 AAS53204.1 - 9.4 6.3 13.6 19 5.3 4.5 3.0 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fer2 PF00111.27 AAS53205.1 - 1.1e-14 54.2 0.2 1.4e-14 53.8 0.2 1.2 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain V-SNARE_C PF12352.8 AAS53206.1 - 9.6e-17 61.0 2.7 9.6e-17 61.0 2.7 2.5 2 1 1 3 3 3 2 Snare region anchored in the vesicle membrane C-terminus V-SNARE PF05008.15 AAS53206.1 - 1.7e-15 57.1 2.1 1.7e-15 57.1 2.1 2.2 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus DUF3490 PF11995.8 AAS53206.1 - 0.001 18.9 0.6 0.0025 17.7 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF3490) Sec20 PF03908.13 AAS53206.1 - 0.0046 16.8 5.2 0.011 15.6 1.5 2.5 2 1 0 2 2 2 1 Sec20 Flg_hook PF02120.16 AAS53206.1 - 0.025 14.4 0.3 0.025 14.4 0.3 2.8 2 1 1 3 3 3 0 Flagellar hook-length control protein FliK Nsp1_C PF05064.13 AAS53206.1 - 0.057 13.2 1.0 0.29 11.0 0.3 2.4 1 1 1 2 2 2 0 Nsp1-like C-terminal region Fez1 PF06818.15 AAS53206.1 - 0.23 11.9 7.5 0.38 11.2 7.6 1.3 1 1 0 1 1 1 0 Fez1 Enkurin PF13864.6 AAS53206.1 - 1 9.9 8.8 3.6 8.1 0.6 2.8 1 1 1 3 3 3 0 Calmodulin-binding Exonuc_VII_L PF02601.15 AAS53206.1 - 7.1 6.1 11.3 39 3.7 11.3 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Glyco_hydro_63 PF03200.16 AAS53207.2 - 4.7e-07 29.0 9.2 3.2e-05 22.9 0.2 4.3 5 1 0 5 5 5 2 Glycosyl hydrolase family 63 C-terminal domain MTCP1 PF08991.10 AAS53209.1 - 1.1e-24 86.4 8.9 1.4e-24 86.1 8.9 1.1 1 0 0 1 1 1 1 Mature-T-Cell Proliferation I type YebO PF13974.6 AAS53210.2 - 0.028 14.5 2.4 0.041 14.0 2.4 1.3 1 0 0 1 1 1 0 YebO-like protein RskA PF10099.9 AAS53210.2 - 1 9.6 6.6 1.1 9.6 5.6 1.6 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Ribosomal_L36e PF01158.18 AAS53211.1 - 7.8e-38 128.6 3.0 8.7e-38 128.5 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L36e PRA-PH PF01503.17 AAS53211.1 - 0.15 12.5 0.1 0.33 11.4 0.0 1.6 2 0 0 2 2 2 0 Phosphoribosyl-ATP pyrophosphohydrolase Ribosomal_L28 PF00830.19 AAS53212.1 - 5.3e-21 74.6 0.5 1.5e-20 73.1 0.5 1.8 2 0 0 2 2 2 1 Ribosomal L28 family RabGAP-TBC PF00566.18 AAS53213.2 - 1.1e-50 172.3 1.1 1.1e-50 172.3 1.1 2.5 3 0 0 3 3 3 1 Rab-GTPase-TBC domain LMBR1 PF04791.16 AAS53213.2 - 0.45 9.4 9.7 0.15 11.0 2.8 2.2 2 0 0 2 2 2 0 LMBR1-like membrane protein Spuma_A9PTase PF03539.14 AAS53213.2 - 1.7 8.8 4.9 1.1 9.4 0.5 2.3 1 1 1 2 2 2 0 Spumavirus aspartic protease (A9) NPV_P10 PF05531.12 AAS53213.2 - 2.7 8.5 7.2 0.26 11.8 0.4 2.8 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein BRI3BP PF14965.6 AAS53213.2 - 3.7 7.0 7.1 0.37 10.3 1.1 2.4 2 0 0 2 2 2 0 Negative regulator of p53/TP53 Gal4_dimer PF03902.13 AAS53214.1 - 5.1e-24 84.2 0.8 1.1e-23 83.1 0.8 1.6 1 0 0 1 1 1 1 Gal4-like dimerisation domain Fungal_trans PF04082.18 AAS53214.1 - 4.4e-16 58.7 0.1 7.5e-16 57.9 0.1 1.5 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS53214.1 - 2.9e-07 30.5 15.1 5.1e-07 29.7 15.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RQC PF09382.10 AAS53215.2 - 9.3e-29 99.5 0.3 1.9e-28 98.5 0.3 1.5 1 0 0 1 1 1 1 RQC domain Helicase_C PF00271.31 AAS53215.2 - 9.9e-23 80.6 0.0 7.2e-18 65.0 0.0 3.0 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DEAD PF00270.29 AAS53215.2 - 3.8e-21 75.6 0.0 1e-20 74.3 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 AAS53215.2 - 2.5e-17 63.4 10.2 9.9e-17 61.4 10.2 2.2 1 0 0 1 1 1 1 RecQ zinc-binding Helicase_Sgs1 PF11408.8 AAS53215.2 - 6.8e-07 29.2 0.1 1.6e-06 28.1 0.1 1.7 1 0 0 1 1 1 1 Sgs1 RecQ helicase ResIII PF04851.15 AAS53215.2 - 1.1e-05 25.5 0.0 7.8e-05 22.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ACP_syn_III_C PF08541.10 AAS53215.2 - 0.033 14.4 0.0 0.98 9.6 0.0 2.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DNA_pol_B_N PF18094.1 AAS53215.2 - 0.048 14.2 0.1 0.14 12.7 0.1 1.9 1 0 0 1 1 1 0 DNA polymerase beta N-terminal domain Rhodanese PF00581.20 AAS53215.2 - 0.091 13.3 0.2 0.52 10.9 0.0 2.3 2 0 0 2 2 2 0 Rhodanese-like domain MFS_1 PF07690.16 AAS53216.1 - 1.8e-22 79.7 14.2 2.5e-22 79.3 14.2 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily WD40 PF00400.32 AAS53217.2 - 3.4e-13 49.8 7.1 0.00012 22.8 0.0 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat Ribosomal_S17 PF00366.20 AAS53218.2 - 5.8e-24 84.0 1.2 9.6e-24 83.3 1.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S17 CSD2 PF17876.1 AAS53218.2 - 0.027 14.6 0.0 0.057 13.6 0.0 1.5 1 0 0 1 1 1 0 Cold shock domain OprB PF04966.12 AAS53218.2 - 0.076 12.4 0.9 0.095 12.1 0.9 1.1 1 0 0 1 1 1 0 Carbohydrate-selective porin, OprB family XRN_M PF17846.1 AAS53218.2 - 3.2 6.6 7.4 1.3 7.9 0.2 2.1 2 0 0 2 2 2 0 Xrn1 helical domain Rhomboid PF01694.22 AAS53219.1 - 1.7e-18 67.0 12.8 2.6e-18 66.4 12.8 1.3 1 0 0 1 1 1 1 Rhomboid family DUF2417 PF10329.9 AAS53219.1 - 0.023 14.1 0.9 0.044 13.2 0.9 1.4 1 0 0 1 1 1 0 Region of unknown function (DUF2417) UAA PF08449.11 AAS53220.2 - 6.1e-36 124.2 7.1 7.3e-36 123.9 7.1 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 AAS53220.2 - 9.7e-08 32.3 14.9 6.7e-07 29.5 6.3 2.8 2 1 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 AAS53220.2 - 7.4e-07 28.8 3.6 6.9e-05 22.3 0.4 2.1 2 0 0 2 2 2 2 Triose-phosphate Transporter family BTP PF05232.12 AAS53220.2 - 0.13 12.4 0.4 0.13 12.4 0.4 2.6 2 0 0 2 2 2 0 Chlorhexidine efflux transporter CPP1-like PF11833.8 AAS53220.2 - 0.28 10.8 4.6 0.15 11.7 1.3 2.1 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like SRP68 PF16969.5 AAS53221.1 - 2.2e-46 159.0 8.6 3.3e-46 158.5 8.6 1.2 1 0 0 1 1 1 1 RNA-binding signal recognition particle 68 RINGv PF12906.7 AAS53222.1 - 0.012 15.7 8.1 0.033 14.3 8.1 1.8 1 0 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 AAS53222.1 - 0.83 9.9 7.2 1.5 9.1 3.4 2.6 2 0 0 2 2 2 0 FANCL C-terminal domain DUF3963 PF13124.6 AAS53223.2 - 0.2 11.7 2.3 0.46 10.5 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) RasGAP_C PF03836.15 AAS53224.2 - 1.2e-29 103.2 9.7 2.2e-29 102.3 2.5 2.7 2 0 0 2 2 2 1 RasGAP C-terminus CH PF00307.31 AAS53224.2 - 4.1e-11 43.0 0.0 1.2e-10 41.5 0.0 1.9 1 0 0 1 1 1 1 Calponin homology (CH) domain RasGAP PF00616.19 AAS53224.2 - 5.3e-10 39.4 0.0 1.7e-09 37.7 0.0 1.9 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Trypan_PARP PF05887.11 AAS53224.2 - 6.3e-07 29.4 26.4 6.3e-07 29.4 26.4 2.3 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) IQ PF00612.27 AAS53224.2 - 0.00042 19.9 24.3 7.5 6.7 0.0 8.1 9 0 0 9 9 9 5 IQ calmodulin-binding motif SPESP1 PF15754.5 AAS53224.2 - 0.74 8.9 8.4 2.7 7.1 8.4 1.9 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 TBCC PF07986.12 AAS53225.1 - 0.00066 19.4 2.0 0.0077 16.0 2.0 2.3 1 1 0 1 1 1 1 Tubulin binding cofactor C HSP90 PF00183.18 AAS53226.1 - 1.1e-219 730.6 35.7 1.5e-219 730.2 35.7 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 AAS53226.1 - 1.8e-14 54.2 0.0 4.2e-14 53.0 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AAS53226.1 - 9.2e-10 38.5 0.0 3.6e-09 36.6 0.0 2.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Cofac_haem_bdg PF04187.13 AAS53226.1 - 0.13 12.2 0.1 0.13 12.2 0.1 2.1 3 0 0 3 3 3 0 Haem-binding uptake, Tiki superfamily, ChaN DNTTIP1_dimer PF18192.1 AAS53226.1 - 3.9 7.9 7.0 23 5.4 0.0 3.5 2 1 1 3 3 3 0 DNTTIP1 dimerisation domain Tau95 PF09734.9 AAS53226.1 - 7.7 7.3 9.4 1.5 9.6 3.1 2.8 3 0 0 3 3 3 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain RTP1_C1 PF10363.9 AAS53227.1 - 2.3e-25 88.9 0.0 1.1e-24 86.8 0.0 2.3 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 RTP1_C2 PF10304.9 AAS53227.1 - 0.00024 20.7 0.6 0.00079 19.1 0.6 2.0 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 2 DUF4484 PF14831.6 AAS53227.1 - 0.012 15.7 0.2 0.5 10.4 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) HEAT_2 PF13646.6 AAS53227.1 - 0.014 15.8 8.2 0.04 14.3 0.3 3.9 3 1 0 3 3 3 0 HEAT repeats HEAT PF02985.22 AAS53227.1 - 0.038 14.2 0.6 30 5.3 0.1 4.1 3 0 0 3 3 3 0 HEAT repeat Ank_2 PF12796.7 AAS53228.1 - 6.2e-23 81.2 1.2 6.3e-15 55.5 0.1 1.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AAS53228.1 - 1.1e-15 57.5 2.2 2.2e-07 31.0 0.2 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 AAS53228.1 - 1.6e-12 47.7 2.3 4.3e-09 36.7 0.5 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 AAS53228.1 - 6.5e-12 44.5 0.9 3e-05 24.1 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 AAS53228.1 - 7.1e-12 45.2 2.4 2.3e-05 24.6 0.1 3.2 3 0 0 3 3 3 2 Ankyrin repeat eIF-5_eIF-2B PF01873.17 AAS53229.2 - 3.4e-38 130.1 0.2 5.8e-38 129.4 0.2 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 IF2_N PF04760.15 AAS53229.2 - 0.0025 17.6 0.1 0.047 13.5 0.0 2.8 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region TF_Zn_Ribbon PF08271.12 AAS53229.2 - 0.031 13.8 0.5 0.07 12.7 0.2 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding DUF2752 PF10825.8 AAS53229.2 - 0.2 11.7 0.0 0.34 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Arc_trans_TRASH PF08394.10 AAS53229.2 - 3.3 8.1 6.2 31 5.0 2.4 2.7 1 1 1 2 2 2 0 Archaeal TRASH domain Pkinase PF00069.25 AAS53231.1 - 3e-23 82.5 0.0 3.8e-15 56.0 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53231.1 - 9.2e-09 35.0 0.0 4.4e-08 32.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase TIP49 PF06068.13 AAS53232.2 - 3.6e-157 523.1 1.0 4.6e-157 522.7 1.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AAS53232.2 - 4.1e-26 90.9 0.8 1.3e-25 89.3 0.6 2.0 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 AAS53232.2 - 7.6e-08 32.9 3.8 6.4e-05 23.4 0.1 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AAS53232.2 - 1.9e-07 31.0 0.4 0.0019 18.0 0.0 2.5 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain DnaB_C PF03796.15 AAS53232.2 - 2.3e-05 23.9 0.2 5.7e-05 22.6 0.2 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 AAS53232.2 - 3.2e-05 24.4 0.1 0.00013 22.4 0.1 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS53232.2 - 0.00038 20.7 0.0 0.081 13.2 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_19 PF13245.6 AAS53232.2 - 0.0064 16.8 1.7 0.033 14.5 0.5 2.5 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AAS53232.2 - 0.0066 16.5 0.6 1.1 9.3 0.0 3.1 2 2 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 AAS53232.2 - 0.0097 16.2 0.0 0.033 14.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AAS53232.2 - 0.011 15.1 0.9 0.25 10.7 0.3 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 AAS53232.2 - 0.011 15.3 0.2 0.026 14.1 0.2 1.5 1 0 0 1 1 1 0 AAA domain TFIID_20kDa PF03847.13 AAS53232.2 - 0.059 13.9 0.1 0.17 12.4 0.1 1.7 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A Sigma54_activat PF00158.26 AAS53232.2 - 0.067 12.9 0.0 9 6.0 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain ATP-synt_C PF00137.21 AAS53233.1 - 1e-31 109.0 32.4 1.5e-19 70.1 10.8 2.1 2 0 0 2 2 2 2 ATP synthase subunit C Mis14 PF08641.12 AAS53234.1 - 5.2e-35 120.6 3.0 5.8e-35 120.5 0.5 2.0 2 0 0 2 2 2 1 Kinetochore protein Mis14 like Syntaxin PF00804.25 AAS53235.1 - 2.4e-20 73.1 16.0 2.4e-20 73.1 16.0 2.4 1 1 1 2 2 2 1 Syntaxin SNARE PF05739.19 AAS53235.1 - 6.1e-14 51.8 2.9 6.1e-14 51.8 2.9 2.1 2 0 0 2 2 2 1 SNARE domain Thr_dehydrat_C PF00585.18 AAS53235.1 - 0.0028 17.4 2.1 0.012 15.3 0.1 2.7 2 1 1 3 3 3 1 C-terminal regulatory domain of Threonine dehydratase Synaptobrevin PF00957.21 AAS53235.1 - 0.0029 17.4 2.9 0.0029 17.4 2.9 2.0 2 0 0 2 2 2 1 Synaptobrevin DUF745 PF05335.13 AAS53235.1 - 0.0053 16.5 8.1 0.0053 16.5 8.1 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF745) Herpes_US9 PF06072.11 AAS53235.1 - 0.011 15.6 0.2 0.023 14.6 0.2 1.5 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 SKA1 PF07160.12 AAS53235.1 - 0.022 14.6 3.4 0.022 14.6 3.4 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF948 PF06103.11 AAS53235.1 - 0.024 14.9 3.1 0.024 14.9 3.1 3.2 3 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) Chordopox_A33R PF05966.12 AAS53235.1 - 0.12 11.6 0.5 0.74 9.1 0.1 2.0 2 0 0 2 2 2 0 Chordopoxvirus A33R protein OppC_N PF12911.7 AAS53235.1 - 1.8 8.6 3.3 3.6 7.7 3.3 1.4 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C Allexi_40kDa PF05549.11 AAS53235.1 - 3.8 6.9 6.1 5.6 6.4 0.3 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein DUF4094 PF13334.6 AAS53235.1 - 5.2 7.6 7.7 1.3 9.4 0.4 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4094) PBP1_TM PF14812.6 AAS53235.1 - 5.6 7.4 7.4 1.4 9.4 0.1 2.8 2 1 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1542 PF07564.11 AAS53235.1 - 6.5 6.9 16.4 2.6 8.2 4.2 3.3 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1542) Fas_alpha_ACP PF18325.1 AAS53236.2 - 6.3e-72 241.2 0.1 1.7e-71 239.8 0.1 1.8 1 0 0 1 1 1 1 Fatty acid synthase subunit alpha Acyl carrier domain FAS_I_H PF18314.1 AAS53236.2 - 5e-67 225.5 0.4 5e-67 225.5 0.4 2.1 3 0 0 3 3 3 1 Fatty acid synthase type I helical domain ketoacyl-synt PF00109.26 AAS53236.2 - 1.9e-18 67.0 0.1 3.7e-18 66.0 0.1 1.5 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain ACPS PF01648.20 AAS53236.2 - 1.2e-15 57.6 0.1 4.1e-15 55.9 0.0 2.0 2 0 0 2 2 2 1 4'-phosphopantetheinyl transferase superfamily Ketoacyl-synt_C PF02801.22 AAS53236.2 - 3.8e-13 49.5 0.0 1.1e-12 47.9 0.0 1.8 1 0 0 1 1 1 1 Beta-ketoacyl synthase, C-terminal domain KR PF08659.10 AAS53236.2 - 0.00084 19.3 0.3 0.0033 17.3 0.0 2.1 2 0 0 2 2 2 1 KR domain Polysacc_synt_2 PF02719.15 AAS53236.2 - 0.13 11.4 0.1 0.23 10.6 0.1 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF3597 PF12200.8 AAS53236.2 - 1.2 9.7 7.8 4.6 7.8 7.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) Axin_b-cat_bind PF08833.10 AAS53237.1 - 0.3 11.2 2.1 1.4 9.1 0.7 2.2 2 0 0 2 2 2 0 Axin beta-catenin binding domain zf-C2H2 PF00096.26 AAS53238.2 - 1.7e-10 40.7 10.6 1.1e-05 25.6 1.4 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS53238.2 - 2.5e-09 37.1 2.1 2.5e-09 37.1 2.1 2.6 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS53238.2 - 4.2e-06 27.1 7.0 0.0025 18.5 0.8 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AAS53238.2 - 0.00019 21.7 3.2 0.011 16.1 0.3 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.6 AAS53238.2 - 0.0088 16.0 0.2 0.023 14.7 0.2 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_5 PF13909.6 AAS53238.2 - 0.021 14.6 1.3 1.7 8.5 0.3 2.6 2 0 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2HE PF16278.5 AAS53238.2 - 0.026 15.0 1.7 0.06 13.8 1.7 1.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 AAS53238.2 - 0.027 14.8 4.5 0.055 13.8 0.5 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf_C2H2_ZHX PF18387.1 AAS53238.2 - 0.043 13.5 1.7 1.2 8.8 0.1 2.3 1 1 1 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain mRNA_triPase PF02940.15 AAS53240.2 - 5.3e-66 222.5 1.8 7.5e-66 222.0 1.8 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, beta chain Glycos_transf_2 PF00535.26 AAS53241.2 - 6.9e-29 100.8 0.0 9e-29 100.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AAS53241.2 - 4.6e-10 39.8 0.0 6e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AAS53241.2 - 3.4e-05 24.3 0.0 7.7e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 AAS53241.2 - 0.0086 15.6 0.0 0.012 15.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 ABC_tran PF00005.27 AAS53243.2 - 1.4e-46 158.4 0.1 8.2e-26 91.1 0.0 4.1 3 2 0 3 3 2 2 ABC transporter AAA_21 PF13304.6 AAS53243.2 - 1.2e-15 58.1 2.4 4.3e-05 23.5 0.7 4.4 3 1 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS53243.2 - 3e-11 43.2 0.0 0.00072 19.1 0.0 3.7 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain Chromo PF00385.24 AAS53243.2 - 1.1e-09 38.1 4.2 2.1e-09 37.1 4.2 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_23 PF13476.6 AAS53243.2 - 2.2e-07 31.6 5.1 0.00071 20.1 0.0 3.0 3 0 0 3 3 2 2 AAA domain MMR_HSR1 PF01926.23 AAS53243.2 - 2.8e-07 30.6 0.1 0.0043 17.1 0.0 2.9 3 0 0 3 3 2 2 50S ribosome-binding GTPase AAA_29 PF13555.6 AAS53243.2 - 4.5e-07 29.5 1.0 0.005 16.6 0.2 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AAS53243.2 - 1.7e-06 28.1 0.1 0.015 15.2 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_22 PF13401.6 AAS53243.2 - 1.2e-05 25.6 0.0 0.27 11.5 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AAS53243.2 - 0.00032 20.5 2.0 0.13 11.9 0.2 3.2 3 1 1 4 4 3 1 AAA ATPase domain AAA_18 PF13238.6 AAS53243.2 - 0.00032 21.2 0.3 0.26 11.8 0.0 3.2 3 0 0 3 3 3 1 AAA domain MeaB PF03308.16 AAS53243.2 - 0.00047 19.2 0.3 0.77 8.7 0.1 2.5 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 AAS53243.2 - 0.00049 20.3 4.5 0.085 12.9 0.0 4.1 4 0 0 4 4 4 1 Helicase HerA, central domain AAA_28 PF13521.6 AAS53243.2 - 0.00056 20.2 0.0 0.12 12.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 AAS53243.2 - 0.0012 19.2 0.1 1.4 9.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 AAS53243.2 - 0.0036 17.5 0.0 2 8.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AAS53243.2 - 0.0041 17.5 0.2 0.59 10.5 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain NACHT PF05729.12 AAS53243.2 - 0.0042 17.0 0.2 2.3 8.1 0.0 2.6 2 0 0 2 2 2 1 NACHT domain AAA_30 PF13604.6 AAS53243.2 - 0.0051 16.6 0.1 3.8 7.2 0.0 3.2 3 1 0 3 3 2 1 AAA domain AAA_27 PF13514.6 AAS53243.2 - 0.0076 15.9 0.0 3.6 7.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AAS53243.2 - 0.012 15.3 0.4 0.75 9.5 0.1 2.5 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 AAS53243.2 - 0.015 15.3 0.2 0.6 10.1 0.0 3.2 3 0 0 3 3 3 0 Dynamin family AAA_13 PF13166.6 AAS53243.2 - 0.019 13.7 0.0 2.6 6.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 AAS53243.2 - 0.028 14.8 0.0 4.3 7.8 0.0 3.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 AAS53243.2 - 0.038 13.2 0.1 1.9 7.6 0.0 2.4 2 0 0 2 2 2 0 NB-ARC domain Roc PF08477.13 AAS53243.2 - 0.04 14.1 0.0 9.3 6.5 0.0 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase DUF3584 PF12128.8 AAS53243.2 - 0.057 10.9 0.8 4.6 4.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) NTPase_1 PF03266.15 AAS53243.2 - 0.064 13.2 0.3 6 6.8 0.2 2.7 3 0 0 3 3 2 0 NTPase DUF815 PF05673.13 AAS53243.2 - 0.069 12.3 0.4 4.2 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 AAS53243.2 - 0.07 12.9 0.0 13 5.5 0.0 3.1 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 AAS53243.2 - 0.14 12.1 0.2 0.9 9.4 0.0 2.1 2 0 0 2 2 2 0 Rad17 P-loop domain TsaE PF02367.17 AAS53243.2 - 0.16 11.9 0.1 24 5.0 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CLP1_P PF16575.5 AAS53243.2 - 0.18 11.6 0.3 12 5.6 0.0 3.0 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop cobW PF02492.19 AAS53243.2 - 0.33 10.5 1.4 28 4.2 0.1 3.2 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran_Xtn PF12848.7 AAS53243.2 - 0.55 10.3 6.4 0.12 12.4 0.6 2.5 2 0 0 2 2 2 0 ABC transporter MoCF_biosynth PF00994.24 AAS53244.1 - 3.1e-32 111.2 0.0 4.6e-32 110.7 0.0 1.3 1 0 0 1 1 1 1 Probable molybdopterin binding domain SpoVIF PF14069.6 AAS53244.1 - 0.18 11.6 0.1 0.37 10.6 0.1 1.4 1 0 0 1 1 1 0 Stage VI sporulation protein F Polysacc_synt_4 PF04669.13 AAS53245.1 - 5.4e-18 65.2 0.8 2.9e-16 59.6 0.8 2.0 1 1 0 1 1 1 1 Polysaccharide biosynthesis NitrOD1 PF18549.1 AAS53245.1 - 0.056 13.4 0.2 0.15 12.1 0.2 1.7 1 0 0 1 1 1 0 Nitrosopumilus output domain 1 Cation_efflux PF01545.21 AAS53246.2 - 5.6e-49 166.6 10.6 7.2e-49 166.2 10.6 1.1 1 0 0 1 1 1 1 Cation efflux family ARID PF01388.21 AAS53247.1 - 3.4e-17 62.9 0.1 3.8e-16 59.5 0.0 2.7 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain PLU-1 PF08429.11 AAS53247.1 - 1.7e-13 50.5 0.0 4.2e-13 49.2 0.0 1.7 1 0 0 1 1 1 1 PLU-1-like protein JmjC PF02373.22 AAS53247.1 - 3.3e-12 46.8 0.1 7.4e-07 29.6 0.0 2.7 2 0 0 2 2 2 2 JmjC domain, hydroxylase PHD PF00628.29 AAS53247.1 - 5.8e-05 22.9 9.4 0.00013 21.8 9.4 1.6 1 0 0 1 1 1 1 PHD-finger JmjN PF02375.17 AAS53247.1 - 0.047 13.7 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 jmjN domain CRPV_capsid PF08762.10 AAS53247.1 - 0.11 12.1 0.3 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 CRPV capsid protein like PHD_4 PF16866.5 AAS53247.1 - 0.29 11.2 5.0 2 8.5 5.2 2.4 1 1 0 1 1 1 0 PHD-finger zf-HC5HC2H PF13771.6 AAS53247.1 - 0.97 9.7 5.7 2.7 8.3 5.7 1.7 1 0 0 1 1 1 0 PHD-like zinc-binding domain Keratin_B2 PF01500.17 AAS53248.2 - 0.43 10.6 28.3 0.55 10.2 28.3 1.1 1 0 0 1 1 1 0 Keratin, high sulfur B2 protein Keratin_B2_2 PF13885.6 AAS53248.2 - 3.3 7.7 39.5 53 3.9 39.4 2.2 1 1 0 1 1 1 0 Keratin, high sulfur B2 protein GCR1_C PF12550.8 AAS53250.1 - 3.7e-24 84.9 1.0 7.8e-24 83.8 1.0 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Gp-FAR-1 PF05823.12 AAS53250.1 - 0.019 15.3 3.9 1.4 9.3 0.3 2.8 3 0 0 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) PLAC9 PF15205.6 AAS53250.1 - 0.1 13.0 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Placenta-specific protein 9 DUF1043 PF06295.12 AAS53250.1 - 0.43 10.6 2.9 0.76 9.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) SlyX PF04102.12 AAS53250.1 - 1.3 9.7 6.0 0.19 12.4 1.5 2.0 2 0 0 2 2 2 0 SlyX UPF0061 PF02696.14 AAS53251.2 - 2.5e-143 478.3 0.0 3.3e-143 477.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Lon_C PF05362.13 AAS53253.2 - 3.5e-43 147.5 0.0 5.8e-43 146.8 0.0 1.3 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain AAA PF00004.29 AAS53253.2 - 2.4e-18 66.8 0.0 5.8e-18 65.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AAS53253.2 - 4.7e-08 33.1 0.0 2.3e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 AAS53253.2 - 1.8e-05 24.5 0.0 3.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase RuvB_N PF05496.12 AAS53253.2 - 3.3e-05 23.7 0.0 7.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain LON_substr_bdg PF02190.16 AAS53253.2 - 6.1e-05 23.0 0.0 0.00051 20.0 0.0 2.5 2 1 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_16 PF13191.6 AAS53253.2 - 0.00011 22.6 0.0 0.00062 20.2 0.0 2.3 3 0 0 3 3 2 1 AAA ATPase domain AAA_2 PF07724.14 AAS53253.2 - 0.00025 21.2 0.0 0.00061 19.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AAS53253.2 - 0.00066 20.0 0.0 0.049 13.9 0.0 3.2 2 1 1 3 3 3 1 AAA domain AAA_3 PF07726.11 AAS53253.2 - 0.0018 18.1 0.0 0.0038 17.1 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AAS53253.2 - 0.021 14.8 0.0 0.047 13.6 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_33 PF13671.6 AAS53253.2 - 0.024 14.8 0.0 0.052 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AAS53253.2 - 0.035 13.5 0.0 0.14 11.5 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AAS53253.2 - 0.059 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 AAS53253.2 - 0.11 12.4 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 NTPase GREB1 PF15782.5 AAS53253.2 - 0.25 8.4 0.0 0.35 8.0 0.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TRP PF06011.12 AAS53254.1 - 2.8e-151 504.0 33.6 3.4e-151 503.8 33.6 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel TRP_N PF14558.6 AAS53254.1 - 1.1e-39 136.0 0.3 1.9e-39 135.2 0.3 1.4 1 0 0 1 1 1 1 ML-like domain Coatomer_WDAD PF04053.14 AAS53256.1 - 9.1e-169 562.2 0.8 2.5e-167 557.5 0.1 2.1 2 0 0 2 2 2 1 Coatomer WD associated region WD40 PF00400.32 AAS53256.1 - 2.7e-33 113.5 7.1 5.6e-06 27.0 0.0 8.4 8 1 1 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53256.1 - 9.4e-07 29.1 0.4 3.3 8.1 0.0 6.6 6 3 2 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS53256.1 - 8.8e-06 24.6 6.4 0.02 13.5 0.1 4.4 1 1 2 5 5 5 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 AAS53256.1 - 7.6e-05 22.7 0.2 0.39 10.8 0.0 4.9 3 2 3 6 6 6 1 Ciliary BBSome complex subunit 2, middle region MetallophosC PF16370.5 AAS53256.1 - 0.038 14.2 2.7 0.059 13.6 0.1 2.7 3 1 1 4 4 4 0 C terminal of Calcineurin-like phosphoesterase FtsJ PF01728.19 AAS53257.2 - 4.6e-57 193.0 0.0 6.1e-57 192.6 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 AAS53257.2 - 0.00027 20.8 0.0 0.0014 18.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS53257.2 - 0.0047 16.7 0.0 0.38 10.6 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 AAS53257.2 - 0.15 12.8 0.0 0.99 10.2 0.0 2.4 2 1 1 3 3 3 0 Methyltransferase domain Ribosomal_L1 PF00687.21 AAS53258.1 - 1.5e-42 145.6 0.9 1.9e-42 145.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Cyclin PF08613.11 AAS53259.1 - 1.2e-13 51.8 0.0 2.2e-13 50.9 0.0 1.5 1 0 0 1 1 1 1 Cyclin Arf PF00025.21 AAS53260.1 - 3.5e-65 218.7 0.0 4e-65 218.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 AAS53260.1 - 3.8e-09 36.2 0.3 5.9e-06 25.7 0.0 2.5 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 AAS53260.1 - 2.7e-07 30.3 0.0 3.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 AAS53260.1 - 1.2e-06 28.1 0.0 1.5e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AAS53260.1 - 1.2e-06 28.7 0.0 3.9e-06 27.1 0.0 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 AAS53260.1 - 1.5e-05 25.1 0.0 1.9e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AAS53260.1 - 0.00042 19.8 0.0 0.00047 19.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region PduV-EutP PF10662.9 AAS53260.1 - 0.11 12.2 0.0 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RIBIOP_C PF04950.12 AAS53261.2 - 1.2e-88 297.3 0.2 1.2e-88 297.3 0.2 2.7 3 0 0 3 3 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 AAS53261.2 - 4.8e-27 93.9 0.0 1.6e-26 92.2 0.0 2.0 1 0 0 1 1 1 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 AAS53261.2 - 1.4e-06 28.0 0.0 0.00077 19.1 0.0 2.8 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 AAS53261.2 - 5.2e-06 27.0 0.0 1.8e-05 25.2 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA PF00004.29 AAS53261.2 - 5.3e-06 26.9 0.0 1.6e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AAS53261.2 - 6.1e-06 26.5 0.0 2.4e-05 24.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AAS53261.2 - 9.7e-05 22.7 0.0 0.00044 20.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AAS53261.2 - 0.00058 19.9 0.2 0.0036 17.4 0.1 2.5 2 0 0 2 2 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AAS53261.2 - 0.0034 17.9 0.0 0.0034 17.9 0.0 2.6 3 0 0 3 3 1 1 ABC transporter Zeta_toxin PF06414.12 AAS53261.2 - 0.0036 16.6 0.3 0.11 11.7 0.0 2.6 1 1 1 2 2 2 1 Zeta toxin AAA_19 PF13245.6 AAS53261.2 - 0.004 17.5 0.1 0.011 16.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 AAS53261.2 - 0.004 16.4 0.3 0.033 13.4 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain AAA_18 PF13238.6 AAS53261.2 - 0.0078 16.8 0.1 0.0078 16.8 0.1 3.9 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 AAS53261.2 - 0.0091 15.9 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain RNA_helicase PF00910.22 AAS53261.2 - 0.012 16.0 0.0 0.035 14.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase AAA_30 PF13604.6 AAS53261.2 - 0.012 15.3 0.1 0.012 15.3 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AAS53261.2 - 0.015 15.6 0.1 0.015 15.6 0.1 2.2 2 0 0 2 2 1 0 AAA domain AAA_11 PF13086.6 AAS53261.2 - 0.016 15.0 0.1 0.016 15.0 0.1 3.8 4 1 0 4 4 4 0 AAA domain AAA_5 PF07728.14 AAS53261.2 - 0.016 15.2 0.1 0.052 13.6 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 AAS53261.2 - 0.02 14.4 0.3 0.056 12.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_24 PF13479.6 AAS53261.2 - 0.022 14.5 2.7 0.11 12.2 0.1 2.6 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AAS53261.2 - 0.031 13.9 0.3 0.071 12.7 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 AAS53261.2 - 0.037 13.9 0.6 0.074 13.0 0.6 1.5 1 0 0 1 1 1 0 NTPase AAA_25 PF13481.6 AAS53261.2 - 0.064 12.8 0.0 0.17 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AAS53261.2 - 0.08 12.8 1.0 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase MobB PF03205.14 AAS53261.2 - 0.095 12.6 3.4 0.11 12.4 0.2 2.7 4 0 0 4 4 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.9 AAS53261.2 - 0.097 12.4 0.0 0.96 9.2 0.0 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation WAC_Acf1_DNA_bd PF10537.9 AAS53262.2 - 6.3e-35 119.7 1.3 6.3e-35 119.7 1.3 2.4 2 0 0 2 2 2 1 ATP-utilising chromatin assembly and remodelling N-terminal WSD PF15613.6 AAS53262.2 - 2.4e-08 34.3 1.2 2.4e-07 31.1 0.0 3.4 3 1 0 3 3 3 1 Williams-Beuren syndrome DDT (WSD), D-TOX E motif DDT PF02791.17 AAS53262.2 - 8.6e-08 32.4 2.1 7.1e-06 26.2 0.1 2.7 2 0 0 2 2 2 1 DDT domain WHIM1 PF15612.6 AAS53262.2 - 7.8e-05 22.1 0.1 0.00021 20.8 0.1 1.8 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 DUF4349 PF14257.6 AAS53262.2 - 0.5 9.8 6.1 1.4 8.3 6.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) TEX19 PF15553.6 AAS53262.2 - 1.7 8.6 4.4 0.84 9.6 0.2 2.5 2 0 0 2 2 2 0 Testis-expressed protein 19 Ubiq_cyt_C_chap PF03981.12 AAS53263.2 - 3.5e-43 147.1 0.6 5.4e-43 146.5 0.6 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone 2C_adapt PF08793.10 AAS53263.2 - 0.16 12.2 0.2 0.4 10.9 0.0 1.8 2 0 0 2 2 2 0 2-cysteine adaptor domain HK PF02110.15 AAS53264.1 - 3.2e-72 242.9 0.1 5e-72 242.2 0.1 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family TMP-TENI PF02581.17 AAS53264.1 - 5.4e-55 185.5 0.0 8.2e-55 184.9 0.0 1.3 1 0 0 1 1 1 1 Thiamine monophosphate synthase Phos_pyr_kin PF08543.12 AAS53264.1 - 0.0021 17.5 1.4 0.029 13.8 0.2 3.0 3 1 0 3 3 3 1 Phosphomethylpyrimidine kinase Carb_kinase PF01256.17 AAS53264.1 - 0.07 12.6 0.0 0.17 11.3 0.0 1.7 1 1 0 1 1 1 0 Carbohydrate kinase LRR_9 PF14580.6 AAS53265.1 - 5.8e-14 52.0 0.7 9.1e-14 51.3 0.1 1.6 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 AAS53265.1 - 0.017 15.5 6.4 0.059 13.8 0.3 3.3 1 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 AAS53265.1 - 0.54 10.5 3.0 7.5 6.9 0.0 3.4 3 0 0 3 3 3 0 Leucine Rich repeat LRR_8 PF13855.6 AAS53265.1 - 4.7 7.0 6.9 10 6.0 4.8 2.6 2 1 0 2 2 2 0 Leucine rich repeat BAH PF01426.18 AAS53266.2 - 6.6e-14 51.8 0.0 1.7e-13 50.5 0.0 1.7 1 0 0 1 1 1 1 BAH domain PHD PF00628.29 AAS53266.2 - 8.6e-14 51.2 51.9 3e-07 30.2 9.4 5.7 5 1 1 6 6 6 3 PHD-finger zf-HC5HC2H_2 PF13832.6 AAS53266.2 - 1e-12 48.2 1.5 1e-12 48.2 1.5 5.1 5 1 0 5 5 5 1 PHD-zinc-finger like domain PHD_2 PF13831.6 AAS53266.2 - 6.6e-08 32.0 9.8 1.1e-07 31.2 2.1 5.2 6 0 0 6 6 6 3 PHD-finger zf-HC5HC2H PF13771.6 AAS53266.2 - 1.1e-07 32.0 2.4 1.1e-07 32.0 2.4 5.4 5 0 0 5 5 5 1 PHD-like zinc-binding domain Myb_DNA-binding PF00249.31 AAS53266.2 - 0.0033 17.6 0.0 0.009 16.2 0.0 1.8 1 0 0 1 1 1 1 Myb-like DNA-binding domain FYVE_2 PF02318.16 AAS53266.2 - 0.0062 16.7 2.1 0.0062 16.7 2.1 5.8 7 1 0 7 7 7 1 FYVE-type zinc finger C1_2 PF03107.16 AAS53266.2 - 0.035 14.4 0.4 0.035 14.4 0.4 5.7 6 0 0 6 6 6 0 C1 domain zf-RING-like PF08746.11 AAS53266.2 - 3 8.2 22.2 8.5 6.8 2.8 4.6 3 0 0 3 3 3 0 RING-like domain mRNA_cap_enzyme PF01331.19 AAS53267.1 - 3.1e-60 203.4 0.0 5.2e-60 202.6 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 AAS53267.1 - 9.8e-32 109.8 0.3 1.7e-31 109.0 0.3 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 AAS53267.1 - 3e-06 27.0 0.0 0.003 17.2 0.0 3.0 1 1 0 1 1 1 1 ATP dependent DNA ligase domain LTXXQ PF07813.12 AAS53267.1 - 0.19 12.4 0.5 0.78 10.5 0.5 1.9 1 1 0 1 1 1 0 LTXXQ motif family protein DAP3 PF10236.9 AAS53268.2 - 2.3e-91 306.3 0.1 2.9e-91 305.9 0.1 1.1 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_16 PF13191.6 AAS53268.2 - 3.3e-06 27.6 0.1 8.7e-06 26.2 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 AAS53268.2 - 0.0025 17.6 0.1 0.0058 16.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 AAS53268.2 - 0.0025 17.8 0.1 0.0072 16.3 0.1 1.9 1 1 0 1 1 1 1 NTPase MeaB PF03308.16 AAS53268.2 - 0.0027 16.7 0.1 0.0049 15.9 0.1 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 AAS53268.2 - 0.0039 16.9 0.0 0.0096 15.7 0.0 1.6 2 0 0 2 2 2 1 IstB-like ATP binding protein RsgA_GTPase PF03193.16 AAS53268.2 - 0.0044 16.9 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_25 PF13481.6 AAS53268.2 - 0.0057 16.2 0.0 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AAS53268.2 - 0.007 16.1 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain Zeta_toxin PF06414.12 AAS53268.2 - 0.0099 15.2 0.0 0.024 13.9 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.6 AAS53268.2 - 0.012 15.9 0.1 0.097 12.9 0.1 2.2 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AAS53268.2 - 0.013 14.7 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 AAS53268.2 - 0.025 14.5 0.3 0.098 12.6 0.1 2.1 3 0 0 3 3 1 0 NACHT domain AAA PF00004.29 AAS53268.2 - 0.028 14.9 0.0 0.067 13.6 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 AAS53268.2 - 0.03 14.8 0.0 0.14 12.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AAS53268.2 - 0.032 14.0 0.0 0.061 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS53268.2 - 0.045 14.3 0.1 0.12 12.9 0.1 1.8 1 1 0 1 1 1 0 ABC transporter DUF815 PF05673.13 AAS53268.2 - 0.057 12.6 0.0 0.096 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 AAS53268.2 - 0.077 13.0 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) KTI12 PF08433.10 AAS53268.2 - 0.11 11.9 0.0 0.2 11.1 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_33 PF13671.6 AAS53268.2 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain PseudoU_synth_1 PF01416.20 AAS53269.2 - 4.6e-13 49.6 0.0 1.7e-11 44.5 0.0 2.6 2 0 0 2 2 2 1 tRNA pseudouridine synthase PRK PF00485.18 AAS53269.2 - 0.081 12.6 0.4 0.16 11.7 0.4 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Endonuc-MspI PF09208.10 AAS53269.2 - 0.11 11.8 0.1 0.2 11.0 0.1 1.3 1 0 0 1 1 1 0 Restriction endonuclease MspI UPF0113_N PF17833.1 AAS53270.1 - 2.5e-29 101.7 0.1 3.6e-29 101.2 0.1 1.2 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain UPF0113 PF03657.13 AAS53270.1 - 1.8e-24 85.8 0.0 4e-24 84.7 0.0 1.6 1 0 0 1 1 1 1 UPF0113 PUA domain SRP72 PF08492.12 AAS53271.1 - 2.8e-16 59.7 5.6 2.8e-16 59.7 5.6 2.7 2 0 0 2 2 2 1 SRP72 RNA-binding domain TPR_12 PF13424.6 AAS53271.1 - 0.00031 21.0 6.3 0.00054 20.2 0.6 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS53271.1 - 0.00031 20.7 2.9 0.042 14.1 0.2 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Syntaxin_2 PF14523.6 AAS53271.1 - 0.0079 16.5 1.1 0.027 14.8 1.0 1.9 2 0 0 2 2 2 1 Syntaxin-like protein Mad3_BUB1_I PF08311.12 AAS53271.1 - 0.009 16.0 2.6 0.075 13.0 0.2 3.0 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 TPR_2 PF07719.17 AAS53271.1 - 0.0091 16.0 4.0 0.97 9.7 0.0 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 AAS53271.1 - 0.0097 15.9 0.8 0.15 12.2 0.1 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 AAS53271.1 - 0.01 15.8 8.3 0.037 14.1 4.4 3.1 2 1 0 2 2 2 0 Putative TPR-like repeat TPR_19 PF14559.6 AAS53271.1 - 0.018 15.6 15.9 4.4 7.9 3.2 5.3 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 AAS53271.1 - 0.021 14.2 12.4 0.0074 15.7 3.7 2.8 2 1 1 3 3 3 0 MalT-like TPR region TPR_1 PF00515.28 AAS53271.1 - 0.025 14.4 0.3 1.2 9.1 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AAS53271.1 - 0.026 15.3 4.7 6 8.0 0.4 4.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 AAS53271.1 - 0.15 12.0 1.5 2.1 8.3 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DEAD PF00270.29 AAS53272.1 - 1.9e-30 105.9 0.1 3.5e-30 105.1 0.1 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53272.1 - 4.1e-20 72.2 0.1 1.3e-17 64.2 0.0 3.4 4 1 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53272.1 - 5.9e-09 36.1 0.0 2.8e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AAS53272.1 - 1.8e-05 23.6 0.0 2.4e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain AAA_22 PF13401.6 AAS53272.1 - 0.00069 19.9 0.1 0.0063 16.8 0.0 2.3 1 1 1 2 2 2 1 AAA domain Pkinase PF00069.25 AAS53273.1 - 5.9e-71 238.9 0.0 8.1e-71 238.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53273.1 - 1.4e-43 149.0 0.0 1.9e-43 148.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53273.1 - 0.00011 21.7 0.0 0.00017 21.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AAS53273.1 - 0.016 14.0 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase DUF1461 PF07314.11 AAS53273.1 - 0.019 14.9 0.6 0.029 14.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1461) SET PF00856.28 AAS53274.2 - 1.2e-10 42.0 0.0 2.7e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 SET domain DinB_2 PF12867.7 AAS53274.2 - 0.001 19.5 0.6 1.7 9.2 0.1 2.6 2 0 0 2 2 2 2 DinB superfamily Fn3-like PF14310.6 AAS53274.2 - 0.056 13.5 0.2 0.14 12.3 0.2 1.6 1 0 0 1 1 1 0 Fibronectin type III-like domain OmpH PF03938.14 AAS53274.2 - 2.5 8.4 6.8 3.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Wyosine_form PF08608.12 AAS53275.1 - 5.1e-23 81.2 0.0 1.1e-22 80.2 0.0 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AAS53275.1 - 2e-20 73.8 0.0 6.3e-20 72.2 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 AAS53275.1 - 1.9e-10 41.1 0.0 4.1e-10 40.0 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin Glycos_transf_1 PF00534.20 AAS53276.1 - 1.5e-32 112.5 0.0 1.1e-16 60.8 0.0 2.9 3 0 0 3 3 3 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 AAS53276.1 - 1e-13 51.7 0.0 2.4e-13 50.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AAS53276.1 - 1.4e-10 41.7 0.0 5.9e-10 39.7 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AAS53276.1 - 0.02 15.3 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Thermopsin PF05317.11 AAS53276.1 - 0.078 12.4 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Thermopsin Glyco_trans_4_5 PF16994.5 AAS53276.1 - 0.17 11.5 0.0 0.46 10.1 0.0 1.7 2 0 0 2 2 2 0 Glycosyl-transferase family 4 SCA7 PF08313.12 AAS53277.1 - 1.1e-29 102.1 1.0 1.1e-29 102.1 1.0 2.2 3 0 0 3 3 3 1 SCA7, zinc-binding domain zf_C2H2_13 PF18508.1 AAS53277.1 - 2.8e-12 46.0 0.3 6.7e-12 44.8 0.3 1.6 1 0 0 1 1 1 1 Zinc finger domain Utp11 PF03998.13 AAS53277.1 - 0.0052 16.8 6.9 0.0052 16.8 6.9 2.4 2 1 0 2 2 2 1 Utp11 protein GDPD PF03009.17 AAS53278.1 - 8e-29 101.2 0.3 2.3e-28 99.6 0.3 1.7 1 1 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Glyoxalase_4 PF13669.6 AAS53278.1 - 0.00083 19.6 0.0 0.0018 18.5 0.0 1.5 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Flocculin PF00624.18 AAS53279.2 - 1.2e-293 947.1 1316.5 1.6e-12 47.4 25.6 44.7 42 4 2 44 44 44 31 Flocculin repeat GLEYA PF10528.9 AAS53279.2 - 2.9e-23 82.1 1.6 1.8e-21 76.4 1.6 4.6 1 0 0 1 1 1 1 GLEYA domain Flocculin PF00624.18 AAS53280.2 - 3e-54 181.0 196.3 1.6e-13 50.7 24.7 8.9 9 0 0 9 9 9 6 Flocculin repeat GLEYA PF10528.9 AAS53280.2 - 5.6e-22 78.0 4.2 1.3e-21 76.8 1.1 3.4 2 0 0 2 2 2 1 GLEYA domain PA14 PF07691.12 AAS53280.2 - 2.2e-10 40.5 0.4 7.4e-10 38.8 0.0 2.1 2 0 0 2 2 2 1 PA14 domain Malt_amylase_C PF16657.5 AAS53280.2 - 0.058 13.5 0.1 1e+02 3.1 0.0 4.1 2 1 2 4 4 4 0 Maltogenic Amylase, C-terminal domain Pkinase PF00069.25 AAS53281.1 - 3.4e-23 82.4 0.2 6e-23 81.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53281.1 - 2.8e-14 53.0 0.0 6.2e-14 51.9 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS53281.1 - 3.2e-08 32.8 0.1 3.2e-08 32.8 0.1 2.6 3 0 0 3 3 3 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 AAS53281.1 - 0.045 12.7 0.0 0.086 11.8 0.0 1.4 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase ABC1 PF03109.16 AAS53281.1 - 0.048 13.8 0.0 0.85 9.8 0.0 2.4 2 0 0 2 2 2 0 ABC1 family APH PF01636.23 AAS53281.1 - 0.08 12.8 2.8 0.087 12.7 0.0 2.3 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 AAS53282.1 - 4e-71 239.5 0.0 4.9e-71 239.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53282.1 - 9.6e-39 133.2 0.0 1.2e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53282.1 - 8e-06 25.4 0.1 1.8e-05 24.2 0.1 1.6 1 1 0 1 1 1 1 Kinase-like RIO1 PF01163.22 AAS53282.1 - 0.074 12.6 0.1 0.22 11.1 0.1 1.6 1 1 1 2 2 2 0 RIO1 family Kdo PF06293.14 AAS53282.1 - 0.075 12.4 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AAS53282.1 - 0.11 11.5 0.3 0.17 10.8 0.3 1.4 1 1 0 1 1 1 0 Haspin like kinase domain APH PF01636.23 AAS53282.1 - 0.13 12.1 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 AAS53282.1 - 0.18 10.9 0.0 0.29 10.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Ribosomal_L12 PF00542.19 AAS53283.1 - 9.1e-22 77.2 10.6 9.1e-22 77.2 10.6 2.2 2 1 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 AAS53283.1 - 1.2e-14 53.8 9.5 3.9e-14 52.1 5.2 2.6 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain DUF2267 PF10025.9 AAS53283.1 - 0.024 14.9 0.3 0.049 13.9 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) Ribosomal_60s PF00428.19 AAS53283.1 - 5.2 7.7 19.1 0.2 12.3 9.4 2.4 1 1 2 3 3 3 0 60s Acidic ribosomal protein RNA_POL_M_15KD PF02150.16 AAS53284.1 - 8.1e-16 57.6 3.4 8.1e-16 57.6 3.4 2.5 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit TFIIS_C PF01096.18 AAS53284.1 - 3.5e-13 49.2 14.6 6.5e-13 48.3 1.4 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DUF2387 PF09526.10 AAS53284.1 - 0.0054 16.8 3.9 1.3 9.3 0.3 2.4 2 1 0 2 2 2 2 Probable metal-binding protein (DUF2387) Zn_Tnp_IS1 PF03811.13 AAS53284.1 - 0.17 11.6 0.5 0.17 11.6 0.5 3.5 4 0 0 4 4 4 0 InsA N-terminal domain DZR PF12773.7 AAS53284.1 - 0.18 11.8 6.9 1.2 9.3 0.5 2.6 2 1 0 2 2 2 0 Double zinc ribbon zinc_ribbon_10 PF10058.9 AAS53284.1 - 0.33 10.7 6.1 1.8 8.4 0.3 2.5 2 1 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein HypA PF01155.19 AAS53284.1 - 0.98 9.5 5.4 2.5 8.1 3.1 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 AAS53284.1 - 1.2 9.2 12.0 2.6 8.1 3.2 2.5 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 AAS53284.1 - 4.9 7.3 12.2 3.5 7.8 0.1 3.6 3 1 1 4 4 4 0 Zinc ribbon domain AFT PF08731.11 AAS53285.1 - 9.1e-49 164.5 0.0 1.8e-48 163.5 0.0 1.5 1 0 0 1 1 1 1 Transcription factor AFT DBD_Tnp_Mut PF03108.15 AAS53285.1 - 0.019 15.0 0.5 5 7.2 0.0 2.4 2 0 0 2 2 2 0 MuDR family transposase HSF_DNA-bind PF00447.17 AAS53287.2 - 3e-32 111.1 2.5 5.7e-32 110.2 2.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding UPF0181 PF03701.14 AAS53287.2 - 0.14 11.8 0.1 0.42 10.3 0.1 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0181) MPS2 PF17060.5 AAS53288.2 - 3.9e-48 164.6 0.0 1.4e-28 100.3 0.0 2.2 2 0 0 2 2 2 2 Monopolar spindle protein 2 MIP-T3_C PF17749.1 AAS53288.2 - 0.071 13.1 0.8 0.15 12.0 0.8 1.5 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Med9 PF07544.13 AAS53288.2 - 0.089 12.9 1.8 0.23 11.6 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0242 PF06785.11 AAS53288.2 - 0.11 12.7 1.5 0.16 12.0 1.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FliJ PF02050.16 AAS53288.2 - 0.12 12.6 3.2 0.24 11.6 3.2 1.5 1 0 0 1 1 1 0 Flagellar FliJ protein SlyX PF04102.12 AAS53288.2 - 0.39 11.4 2.1 0.9 10.2 0.1 2.3 2 0 0 2 2 2 0 SlyX DHR10 PF18595.1 AAS53288.2 - 2.7 8.1 6.7 21 5.2 0.7 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF1771 PF08590.10 AAS53289.1 - 1.3e-19 70.3 12.6 2e-19 69.7 12.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Smr PF01713.21 AAS53289.1 - 4.5e-11 42.9 0.2 1e-10 41.8 0.2 1.6 1 0 0 1 1 1 1 Smr domain CD225 PF04505.12 AAS53289.1 - 0.63 10.2 2.9 0.96 9.6 0.7 2.1 2 0 0 2 2 2 0 Interferon-induced transmembrane protein CDPS PF16715.5 AAS53289.1 - 0.97 9.0 4.6 1.5 8.4 4.6 1.2 1 0 0 1 1 1 0 Cyclodipeptide synthase Ribosomal_L30_N PF08079.12 AAS53290.1 - 1.4e-21 76.5 18.1 2.5e-21 75.7 18.1 1.4 1 0 0 1 1 1 1 Ribosomal L30 N-terminal domain Ribosomal_L30 PF00327.20 AAS53290.1 - 9.3e-19 67.1 2.5 1.9e-18 66.1 2.5 1.6 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e AA_permease_2 PF13520.6 AAS53291.1 - 2.7e-54 184.7 42.8 3.3e-54 184.3 42.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AAS53291.1 - 1.4e-19 70.0 38.5 2e-19 69.6 38.5 1.1 1 0 0 1 1 1 1 Amino acid permease Insulin_TMD PF17870.1 AAS53291.1 - 0.67 10.1 0.1 0.67 10.1 0.1 3.6 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment DEAD PF00270.29 AAS53292.1 - 1.5e-53 181.2 0.1 1.3e-52 178.2 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53292.1 - 1.5e-35 121.9 0.2 6.9e-31 106.9 0.1 3.1 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53292.1 - 9.8e-10 38.7 2.3 5.9e-09 36.2 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 AAS53292.1 - 0.00011 21.2 0.2 0.0033 16.3 0.1 2.6 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 ERCC3_RAD25_C PF16203.5 AAS53292.1 - 0.00015 21.0 0.1 0.00015 21.0 0.1 1.9 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase CMS1 PF14617.6 AAS53292.1 - 0.021 14.2 0.0 0.021 14.2 0.0 3.1 2 1 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit AAA_22 PF13401.6 AAS53292.1 - 0.16 12.2 1.9 0.54 10.5 0.8 2.4 2 1 0 2 2 2 0 AAA domain Zip PF02535.22 AAS53292.1 - 0.9 8.7 2.1 1.1 8.4 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FA_desaturase PF00487.24 AAS53293.1 - 3.2e-31 109.1 23.1 4.8e-31 108.5 23.1 1.2 1 0 0 1 1 1 1 Fatty acid desaturase Cyt-b5 PF00173.28 AAS53293.1 - 2.1e-11 43.8 0.1 3.8e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TLD PF07534.16 AAS53294.2 - 5.6e-30 104.4 0.0 7.3e-30 104.0 0.0 1.2 1 0 0 1 1 1 1 TLD KxDL PF10241.9 AAS53295.1 - 2.5e-24 85.3 0.9 3.6e-24 84.9 0.9 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein DUF3540 PF12059.8 AAS53295.1 - 0.014 15.3 0.7 0.02 14.7 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3540) Mce4_CUP1 PF11887.8 AAS53295.1 - 0.021 14.3 0.3 0.03 13.8 0.3 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF1664 PF07889.12 AAS53295.1 - 0.16 12.1 0.5 0.24 11.5 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Adaptin_N PF01602.20 AAS53296.1 - 2.9e-115 385.8 16.7 3.9e-115 385.4 16.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AAS53296.1 - 6.4e-10 39.3 5.2 2.1e-09 37.7 0.4 2.7 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DBD_HTH PF18430.1 AAS53296.1 - 0.00088 19.0 2.5 0.002 17.9 0.1 2.7 2 0 0 2 2 2 1 Putative DNA-binding domain HEAT_2 PF13646.6 AAS53296.1 - 0.0016 18.8 0.2 0.44 11.0 0.0 4.5 4 1 2 6 6 6 1 HEAT repeats HEAT PF02985.22 AAS53296.1 - 0.011 15.9 1.1 1.1e+02 3.5 0.0 5.8 6 0 0 6 6 6 0 HEAT repeat Baculo_p74_N PF08404.10 AAS53296.1 - 0.029 13.5 0.6 4.3 6.4 0.1 2.2 2 0 0 2 2 2 0 Baculoviridae P74 N-terminal API5 PF05918.11 AAS53296.1 - 0.071 11.9 0.1 0.071 11.9 0.1 2.8 2 2 1 3 3 3 0 Apoptosis inhibitory protein 5 (API5) Rad9 PF04139.13 AAS53297.1 - 5.7e-12 45.6 0.9 5.6e-05 22.7 0.1 2.3 2 0 0 2 2 2 2 Rad9 MPC PF03650.13 AAS53298.1 - 4.5e-40 136.2 0.0 4.9e-40 136.1 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers NUFIP1 PF10453.9 AAS53299.1 - 5.5e-17 61.4 0.6 1e-16 60.5 0.6 1.4 1 0 0 1 1 1 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) FHA PF00498.26 AAS53300.1 - 0.0012 19.1 0.0 0.0025 18.1 0.0 1.5 1 0 0 1 1 1 1 FHA domain MINDY_DUB PF04424.13 AAS53301.2 - 2.2e-27 95.4 0.0 3.6e-27 94.7 0.0 1.4 1 0 0 1 1 1 1 MINDY deubiquitinase RRM_1 PF00076.22 AAS53302.1 - 8e-11 41.6 0.2 1.7e-10 40.5 0.2 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AAS53302.1 - 5.9e-05 22.7 0.0 0.00031 20.3 0.0 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD-SLDH PF12318.8 AAS53302.1 - 9.6 6.2 7.6 0.65 10.0 2.4 1.7 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase COA2 PF17051.5 AAS53303.1 - 1e-16 60.7 0.1 1.1e-16 60.7 0.1 1.0 1 0 0 1 1 1 1 Cytochrome C oxidase assembly factor 2 Pkinase PF00069.25 AAS53304.1 - 4.9e-19 68.7 0.0 9e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53304.1 - 6.5e-12 45.3 0.1 1.5e-11 44.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase MBOAT PF03062.19 AAS53305.2 - 1.7e-66 225.0 18.0 3.1e-66 224.1 18.0 1.4 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family SNase PF00565.17 AAS53306.1 - 1.9e-22 79.8 0.0 2.9e-22 79.2 0.0 1.2 1 0 0 1 1 1 1 Staphylococcal nuclease homologue MAD PF05557.13 AAS53307.2 - 1.9e-24 86.0 69.6 2.5e-24 85.7 69.6 1.1 1 0 0 1 1 1 1 Mitotic checkpoint protein dCache_1 PF02743.18 AAS53307.2 - 9 6.0 6.8 3 7.6 0.1 2.6 2 1 0 2 2 2 0 Cache domain UQ_con PF00179.26 AAS53308.1 - 2.8e-16 59.4 0.0 3.1e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 AAS53308.1 - 0.032 14.5 0.0 0.037 14.3 0.0 1.2 1 0 0 1 1 1 0 RWD domain NAD_kinase PF01513.21 AAS53309.1 - 9.1e-53 179.3 0.0 1.2e-52 179.0 0.0 1.1 1 0 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AAS53309.1 - 0.032 13.9 0.0 0.061 12.9 0.0 1.5 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain MF_alpha_N PF05436.11 AAS53310.1 - 7.4e-15 54.6 0.0 8.5e-15 54.4 0.0 1.1 1 0 0 1 1 1 1 Mating factor alpha precursor N-terminus RRM_1 PF00076.22 AAS53311.2 - 5.5e-28 96.6 2.5 3.6e-07 29.9 0.1 4.6 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS53311.2 - 1.5e-12 47.2 0.2 0.0031 17.3 0.0 4.4 4 0 0 4 4 4 4 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 AAS53311.2 - 0.05 13.6 0.0 2.8 8.0 0.0 3.0 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AAS53311.2 - 0.061 13.4 0.1 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif RRM_7 PF16367.5 AAS53311.2 - 0.17 12.1 0.1 70 3.6 0.0 3.7 4 0 0 4 4 4 0 RNA recognition motif ParA PF10609.9 AAS53312.2 - 6.6e-92 307.4 0.0 9.2e-92 306.9 0.0 1.2 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 AAS53312.2 - 8.3e-09 35.6 0.0 2.6e-08 34.0 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArsA_ATPase PF02374.15 AAS53312.2 - 4.9e-06 26.0 0.4 3.4e-05 23.2 0.1 2.0 1 1 1 2 2 2 1 Anion-transporting ATPase AAA_31 PF13614.6 AAS53312.2 - 6e-06 26.3 0.2 0.00012 22.0 0.2 2.1 1 1 0 1 1 1 1 AAA domain MipZ PF09140.11 AAS53312.2 - 0.00013 21.4 0.0 0.00025 20.4 0.0 1.5 1 0 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 AAS53312.2 - 0.0066 15.9 0.1 0.011 15.2 0.1 1.5 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ AAA_26 PF13500.6 AAS53312.2 - 0.041 13.7 0.0 0.38 10.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AAS53312.2 - 0.13 12.2 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase CLP1_P PF16575.5 AAS53312.2 - 0.21 11.3 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Nucleoporin2 PF04096.14 AAS53313.1 - 1.3e-47 161.7 0.0 2.5e-47 160.7 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Nup96 PF12110.8 AAS53313.1 - 1.7e-31 109.4 0.2 3e-30 105.3 0.2 2.2 1 1 0 1 1 1 1 Nuclear protein 96 Nucleoporin_FG PF13634.6 AAS53313.1 - 5.3e-10 40.0 87.9 3.3e-05 24.6 31.3 4.9 2 1 2 4 4 4 3 Nucleoporin FG repeat region T2SSC PF11356.8 AAS53313.1 - 0.37 10.7 2.7 0.76 9.7 0.6 2.4 2 0 0 2 2 2 0 Type II secretion system protein C Spc7 PF08317.11 AAS53314.1 - 6.3e-81 271.6 9.0 9.3e-81 271.1 9.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein DP PF08781.10 AAS53314.1 - 0.034 14.0 1.4 0.11 12.4 1.4 1.9 1 0 0 1 1 1 0 Transcription factor DP Rootletin PF15035.6 AAS53314.1 - 0.072 13.1 11.4 5.6 6.9 11.4 2.6 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion NPV_P10 PF05531.12 AAS53314.1 - 0.079 13.4 5.2 1.1 9.7 0.6 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.15 AAS53314.1 - 0.082 13.4 5.2 0.19 12.2 5.2 1.6 1 0 0 1 1 1 0 Fez1 Atg14 PF10186.9 AAS53314.1 - 0.091 11.8 7.2 0.17 10.9 7.2 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7_N PF15402.6 AAS53314.1 - 0.11 10.8 12.7 0.11 10.7 0.0 2.3 1 1 1 2 2 2 0 N-terminus of kinetochore NMS complex subunit Spc7 BLOC1_2 PF10046.9 AAS53314.1 - 0.28 11.5 8.0 1 9.7 0.4 2.8 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Lectin_N PF03954.14 AAS53314.1 - 0.52 10.1 4.7 0.69 9.7 3.4 1.9 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Suppressor_APC PF11414.8 AAS53314.1 - 2.3 8.3 7.9 5.6 7.1 0.8 3.0 1 1 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein DUF1319 PF07028.11 AAS53314.1 - 3 8.1 10.7 0.71 10.1 3.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) DUF4795 PF16043.5 AAS53314.1 - 3.2 7.3 9.6 8.1 6.0 9.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) MIP-T3_C PF17749.1 AAS53314.1 - 4.4 7.3 11.1 0.3 11.1 4.6 2.3 2 1 1 3 3 2 0 Microtubule-binding protein MIP-T3 C-terminal region Fib_alpha PF08702.10 AAS53314.1 - 4.8 7.4 7.6 18 5.5 7.6 2.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 AAS53314.1 - 4.8 7.0 8.7 1.7 8.5 1.4 3.1 3 0 0 3 3 3 0 Septum formation initiator Prefoldin_2 PF01920.20 AAS53314.1 - 5.4 7.0 14.1 0.043 13.8 1.5 2.9 3 0 0 3 3 2 0 Prefoldin subunit Med15_fungi PF05397.12 AAS53314.1 - 5.5 7.3 6.8 2.1 8.7 1.9 2.7 2 1 1 3 3 3 0 Mediator complex subunit 15 Laminin_II PF06009.12 AAS53314.1 - 5.9 6.9 11.0 20 5.2 11.0 1.9 1 0 0 1 1 1 0 Laminin Domain II TMF_TATA_bd PF12325.8 AAS53314.1 - 7.6 6.8 14.3 5.3 7.3 3.8 2.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF1664 PF07889.12 AAS53314.1 - 7.8 6.6 8.4 1.6 8.8 2.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ribosomal_L36 PF00444.18 AAS53315.1 - 1.2e-20 73.4 10.3 1.7e-20 72.9 10.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L36 WD40 PF00400.32 AAS53316.1 - 7.8e-19 67.7 26.0 4.8e-07 30.4 0.2 10.9 11 0 0 11 11 11 4 WD domain, G-beta repeat Nup160 PF11715.8 AAS53316.1 - 2.1e-05 23.4 0.7 0.48 9.0 0.3 4.0 3 1 0 4 4 4 3 Nucleoporin Nup120/160 CPSF_A PF03178.15 AAS53316.1 - 0.0012 18.3 0.1 0.078 12.3 0.0 3.2 4 0 0 4 4 4 1 CPSF A subunit region WD40_like PF17005.5 AAS53316.1 - 0.004 16.5 0.2 1.3 8.3 0.0 3.7 5 1 0 5 5 5 1 WD40-like domain Peptidase_S29 PF02907.15 AAS53316.1 - 0.1 12.4 0.7 0.95 9.2 0.2 2.6 2 0 0 2 2 2 0 Hepatitis C virus NS3 protease UCH_1 PF13423.6 AAS53317.2 - 4.9e-78 262.9 2.9 7.4e-78 262.3 2.9 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RNase_T PF00929.24 AAS53317.2 - 4e-23 82.7 0.0 8.1e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Exonuclease ANAPC4_WD40 PF12894.7 AAS53317.2 - 2.3e-05 24.6 0.0 0.29 11.5 0.0 3.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain UCH PF00443.29 AAS53317.2 - 2.6e-05 23.8 1.4 0.00029 20.4 1.4 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 AAS53317.2 - 0.01 16.7 0.1 4.3 8.4 0.0 3.2 2 0 0 2 2 2 0 WD domain, G-beta repeat Acetyltransf_11 PF13720.6 AAS53317.2 - 0.17 12.3 0.0 1.7 9.1 0.0 2.5 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 DUF3446 PF11928.8 AAS53317.2 - 2 8.8 9.8 3.2 8.1 2.1 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain TCO89 PF10452.9 AAS53318.2 - 3.1e-98 330.3 29.8 7.2e-79 266.3 17.6 2.5 1 1 0 2 2 2 2 TORC1 subunit TCO89 Sec1 PF00995.23 AAS53319.2 - 2.6e-114 383.6 1.4 3e-114 383.4 1.4 1.0 1 0 0 1 1 1 1 Sec1 family CdiI_2 PF18593.1 AAS53319.2 - 0.01 16.5 0.2 0.091 13.4 0.1 2.7 2 0 0 2 2 2 0 CdiI immunity protein Occludin_ELL PF07303.13 AAS53319.2 - 0.11 13.3 2.8 0.37 11.6 0.5 2.9 2 1 1 3 3 3 0 Occludin homology domain PHD PF00628.29 AAS53320.1 - 3.5e-11 42.8 6.3 6.2e-11 42.0 6.3 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 AAS53320.1 - 0.033 13.7 4.6 0.059 12.9 4.6 1.4 1 0 0 1 1 1 0 PHD-finger Metallophos PF00149.28 AAS53321.1 - 1.1e-37 130.5 0.0 2e-37 129.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AAS53321.1 - 1.8e-15 57.1 0.0 3.1e-15 56.3 0.0 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain RRM_1 PF00076.22 AAS53322.1 - 3.4e-15 55.6 0.0 5.7e-15 54.9 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NicO PF03824.16 AAS53322.1 - 0.88 8.9 2.9 1.1 8.5 2.9 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein SelP_N PF04592.14 AAS53322.1 - 7 6.0 13.6 10 5.5 13.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Homeobox_KN PF05920.11 AAS53323.1 - 5.1e-19 67.9 1.2 1e-18 67.0 1.2 1.5 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 AAS53323.1 - 1.4e-06 28.1 0.4 3e-06 27.0 0.4 1.6 1 0 0 1 1 1 1 Homeodomain RasGEF_N PF00618.20 AAS53323.1 - 0.11 12.7 0.0 0.27 11.5 0.0 1.6 1 0 0 1 1 1 0 RasGEF N-terminal motif Arrestin_N PF00339.29 AAS53324.2 - 0.01 15.9 0.1 0.024 14.7 0.1 1.7 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain DAHP_synth_1 PF00793.20 AAS53325.1 - 6e-107 356.6 0.0 7.3e-107 356.3 0.0 1.0 1 0 0 1 1 1 1 DAHP synthetase I family His_biosynth PF00977.21 AAS53326.1 - 7.9e-46 156.4 0.0 4.1e-45 154.0 0.0 2.1 1 1 0 1 1 1 1 Histidine biosynthesis protein GATase PF00117.28 AAS53326.1 - 1.4e-21 77.1 0.0 2.1e-21 76.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 AAS53326.1 - 9.1e-08 31.9 0.0 1.9e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 AAS53326.1 - 1.8e-06 28.0 0.0 0.00029 20.8 0.0 2.2 2 0 0 2 2 2 2 SNO glutamine amidotransferase family ThiG PF05690.14 AAS53326.1 - 0.024 14.0 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG Peptidase_S51 PF03575.17 AAS53326.1 - 0.038 13.6 0.0 0.067 12.8 0.0 1.3 1 0 0 1 1 1 0 Peptidase family S51 UPRTase PF14681.6 AAS53326.1 - 0.18 11.2 0.0 0.32 10.4 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase RCC1 PF00415.18 AAS53327.1 - 2.3e-68 226.6 0.5 5.1e-12 46.2 0.0 7.4 7 1 0 7 7 7 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 AAS53327.1 - 2e-37 126.2 26.5 5.2e-09 35.7 0.0 6.9 8 0 0 8 8 8 6 Regulator of chromosome condensation (RCC1) repeat SUKH-3 PF14433.6 AAS53327.1 - 0.2 12.1 0.4 3.3 8.2 0.0 3.0 4 0 0 4 4 4 0 SUKH-3 immunity protein Bystin PF05291.11 AAS53328.2 - 4.5e-124 413.5 0.2 1e-123 412.3 0.0 1.7 2 0 0 2 2 2 1 Bystin DUF3090 PF11290.8 AAS53328.2 - 2 8.2 8.0 4.3 7.1 8.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3090) Use1 PF09753.9 AAS53329.2 - 5.6e-10 39.4 0.0 6.4e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Prominin PF05478.11 AAS53329.2 - 0.015 13.3 0.0 0.018 13.0 0.0 1.1 1 0 0 1 1 1 0 Prominin Sec20 PF03908.13 AAS53329.2 - 0.048 13.6 0.4 0.11 12.5 0.4 1.6 1 0 0 1 1 1 0 Sec20 Spc7 PF08317.11 AAS53329.2 - 0.22 10.4 3.1 0.37 9.6 3.1 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein HR1 PF02185.16 AAS53329.2 - 0.29 11.3 0.2 0.29 11.3 0.2 3.1 3 0 0 3 3 3 0 Hr1 repeat Golgin_A5 PF09787.9 AAS53329.2 - 0.31 10.5 0.1 0.31 10.5 0.1 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 MMR_HSR1 PF01926.23 AAS53330.2 - 3.2e-17 62.6 0.2 5.6e-15 55.4 0.0 2.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS53330.2 - 3.9e-08 33.0 1.4 3.1e-06 26.8 0.0 2.7 2 1 1 3 3 3 2 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AAS53330.2 - 1.4e-06 28.3 0.1 0.0068 16.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 AAS53330.2 - 0.0027 17.8 1.0 0.024 14.7 0.4 2.6 2 1 0 2 2 2 1 Dynamin family AIG1 PF04548.16 AAS53330.2 - 0.022 14.1 0.0 0.048 13.0 0.0 1.5 1 0 0 1 1 1 0 AIG1 family Snurportin1 PF11538.8 AAS53330.2 - 0.045 13.9 0.7 7.3 6.9 0.0 2.7 2 0 0 2 2 2 0 Snurportin1 PQQ PF01011.21 AAS53331.1 - 0.00093 19.0 4.3 0.023 14.6 0.2 3.4 3 0 0 3 3 3 1 PQQ enzyme repeat PQQ_2 PF13360.6 AAS53331.1 - 0.0034 17.0 3.4 0.049 13.2 1.8 2.8 2 1 0 2 2 2 1 PQQ-like domain WD40 PF00400.32 AAS53331.1 - 0.04 14.8 7.4 38 5.4 0.1 5.5 5 1 0 5 5 5 0 WD domain, G-beta repeat PQQ_3 PF13570.6 AAS53331.1 - 1 10.0 16.2 55 4.4 2.0 5.8 5 2 0 5 5 5 0 PQQ-like domain SNF2_N PF00176.23 AAS53332.1 - 3.2e-75 253.0 0.2 7.2e-75 251.9 0.0 1.7 2 0 0 2 2 2 1 SNF2 family N-terminal domain SLIDE PF09111.10 AAS53332.1 - 1e-38 131.9 2.0 1e-38 131.9 2.0 3.3 3 0 0 3 3 3 1 SLIDE HAND PF09110.11 AAS53332.1 - 2.1e-30 105.7 0.5 2.1e-30 105.7 0.5 4.5 6 0 0 6 6 3 1 HAND Helicase_C PF00271.31 AAS53332.1 - 9.2e-20 71.1 0.0 2.4e-19 69.7 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53332.1 - 3.9e-11 43.2 0.3 4.4e-10 39.8 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS53332.1 - 1.7e-09 37.3 0.0 4.6e-09 35.8 0.0 1.7 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 ERCC3_RAD25_C PF16203.5 AAS53332.1 - 0.00031 20.0 0.1 0.00086 18.6 0.1 1.8 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Myb_DNA-binding PF00249.31 AAS53332.1 - 0.00058 20.0 0.0 0.66 10.2 0.0 3.6 2 0 0 2 2 2 1 Myb-like DNA-binding domain DEAD PF00270.29 AAS53332.1 - 0.00065 19.5 0.0 0.0018 18.1 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_14 PF13173.6 AAS53332.1 - 0.036 14.1 0.3 0.22 11.6 0.0 2.4 2 0 0 2 2 2 0 AAA domain DEAD_2 PF06733.15 AAS53332.1 - 0.062 12.9 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 DEAD_2 GSHPx PF00255.19 AAS53333.1 - 4e-47 158.3 0.4 5.3e-47 157.9 0.4 1.2 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 AAS53333.1 - 3e-07 30.4 0.2 7.6e-07 29.1 0.2 1.7 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AAS53333.1 - 7e-06 25.8 0.1 1.8e-05 24.5 0.1 1.8 1 1 0 1 1 1 1 Redoxin UPF0728 PF15092.6 AAS53333.1 - 0.12 12.2 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0728 WD40 PF00400.32 AAS53334.1 - 4.2e-21 74.9 13.7 9.3e-05 23.1 0.9 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53334.1 - 6.8e-11 42.3 0.3 0.049 13.9 0.1 3.7 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain YmzC PF14157.6 AAS53334.1 - 0.0049 16.9 0.0 0.09 12.9 0.0 2.7 3 0 0 3 3 3 1 YmzC-like protein Ge1_WD40 PF16529.5 AAS53334.1 - 0.0093 15.0 0.1 23 3.8 0.0 3.7 3 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Glycos_transf_4 PF00953.21 AAS53335.1 - 1.5e-32 112.8 10.2 1.5e-32 112.8 10.2 2.6 3 0 0 3 3 3 1 Glycosyl transferase family 4 Phtf-FEM1B_bdg PF12129.8 AAS53335.1 - 0.038 13.8 3.8 0.09 12.6 3.8 1.7 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor DUF1279 PF06916.13 AAS53335.1 - 0.13 12.9 1.0 13 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) HD_3 PF13023.6 AAS53336.2 - 2e-38 131.9 0.2 2.5e-38 131.6 0.2 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 AAS53336.2 - 3.5e-09 36.7 0.0 4.6e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 AAS53336.2 - 1.4e-05 25.3 0.1 2.5e-05 24.5 0.1 1.5 1 0 0 1 1 1 1 HD domain Unstab_antitox PF09720.10 AAS53336.2 - 0.38 10.8 2.0 0.75 9.9 0.2 2.2 2 0 0 2 2 2 0 Putative addiction module component Ribosomal_L27A PF00828.19 AAS53337.1 - 1.9e-22 80.3 0.1 2.9e-22 79.7 0.0 1.3 1 1 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Sugar_tr PF00083.24 AAS53338.2 - 1.3e-99 334.1 12.4 1.7e-99 333.8 12.4 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53338.2 - 5.8e-29 101.1 24.2 5.8e-29 101.1 24.2 2.1 1 1 1 2 2 2 1 Major Facilitator Superfamily MFS_4 PF06779.14 AAS53338.2 - 3.7e-08 33.1 14.6 3.7e-08 33.1 14.6 2.6 1 1 1 2 2 2 1 Uncharacterised MFS-type transporter YbfB MFS_2 PF13347.6 AAS53338.2 - 3.9e-07 29.0 11.7 1.9e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein Zn_clus PF00172.18 AAS53339.1 - 2.6e-10 40.2 3.5 7.3e-10 38.8 3.5 1.8 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain tRNA_bind PF01588.20 AAS53340.1 - 1.2e-26 92.6 0.1 2.5e-26 91.6 0.1 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain Alveol-reg_P311 PF11092.8 AAS53340.1 - 0.03 14.4 0.5 0.51 10.5 0.3 2.6 2 0 0 2 2 2 0 Neuronal protein 3.1 (p311) MDMPI_N PF11716.8 AAS53340.1 - 2.5 8.8 8.8 7.8 7.2 8.8 1.8 1 1 0 1 1 1 0 Mycothiol maleylpyruvate isomerase N-terminal domain PAS PF00989.25 AAS53341.2 - 8.5e-15 54.7 0.0 1.4e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 PAS fold Zn_clus PF00172.18 AAS53341.2 - 4.1e-06 26.8 10.4 7.6e-06 26.0 10.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS_4 PF08448.10 AAS53341.2 - 0.16 12.2 0.0 0.34 11.2 0.0 1.6 1 0 0 1 1 1 0 PAS fold EF-hand_6 PF13405.6 AAS53342.1 - 1.9e-11 42.9 0.8 0.00014 21.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 AAS53342.1 - 6.2e-11 42.6 1.3 4.7e-07 30.2 0.8 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 AAS53342.1 - 2.3e-10 40.7 0.1 0.00073 19.8 0.0 2.5 2 1 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 AAS53342.1 - 1.4e-07 30.6 5.1 0.00099 18.5 0.1 3.0 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 AAS53342.1 - 4.5e-06 26.4 0.6 5.8e-05 22.9 0.4 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_14 PF17959.1 AAS53342.1 - 0.00023 21.4 0.1 0.65 10.4 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_11 PF08976.11 AAS53342.1 - 0.02 15.7 0.0 0.035 15.0 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain GPHH PF16905.5 AAS53342.1 - 0.22 11.3 0.0 11 5.9 0.0 2.3 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated DUF3500 PF12006.8 AAS53344.2 - 0.062 12.8 0.4 0.071 12.6 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3500) DEAD PF00270.29 AAS53345.2 - 1.7e-45 155.0 0.0 4e-45 153.7 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53345.2 - 5.7e-20 71.7 0.2 2.3e-19 69.8 0.1 2.1 1 1 1 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53345.2 - 4.7e-06 26.7 0.0 7.8e-05 22.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit cwf18 PF08315.12 AAS53345.2 - 0.92 10.2 17.4 4.1 8.1 1.7 3.3 3 0 0 3 3 3 0 cwf18 pre-mRNA splicing factor Pox_MCEL PF03291.16 AAS53346.1 - 5.9e-101 337.9 0.5 8.5e-101 337.4 0.5 1.2 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_25 PF13649.6 AAS53346.1 - 4.1e-10 40.2 0.0 8.4e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS53346.1 - 3.2e-08 34.2 0.3 1.3e-07 32.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS53346.1 - 2.6e-06 27.4 0.0 6.7e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS53346.1 - 5.4e-06 26.3 0.1 1.4e-05 24.9 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS53346.1 - 6.7e-06 26.7 0.0 1.7e-05 25.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 AAS53346.1 - 0.0028 16.9 0.0 0.0059 15.8 0.0 1.5 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family Methyltransf_15 PF09445.10 AAS53346.1 - 0.0074 15.9 1.6 0.14 11.7 0.0 2.2 2 0 0 2 2 2 1 RNA cap guanine-N2 methyltransferase MetW PF07021.12 AAS53346.1 - 0.041 13.5 0.0 0.086 12.4 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PCMT PF01135.19 AAS53346.1 - 0.095 12.4 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ret2_MD PF18528.1 AAS53346.1 - 0.17 12.2 1.8 0.21 12.0 0.5 1.8 2 0 0 2 2 2 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF4603 PF15376.6 AAS53346.1 - 0.36 8.2 3.6 0.45 7.8 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) AA_permease PF00324.21 AAS53347.1 - 1e-47 162.8 36.1 1e-47 162.8 36.1 1.6 2 0 0 2 2 2 1 Amino acid permease SLC12 PF03522.15 AAS53347.1 - 4e-16 59.1 3.1 5.9e-07 28.9 0.0 3.2 3 0 0 3 3 3 3 Solute carrier family 12 CUE PF02845.16 AAS53348.1 - 1.2e-09 37.7 0.2 3e-09 36.4 0.2 1.7 1 0 0 1 1 1 1 CUE domain WD40 PF00400.32 AAS53350.1 - 7.7e-11 42.4 5.2 0.007 17.2 0.5 5.9 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53350.1 - 5.4e-08 33.0 0.3 0.018 15.3 0.0 4.3 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS53350.1 - 0.0034 17.3 0.1 0.059 13.2 0.0 2.5 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DASH_Dad3 PF08656.10 AAS53351.1 - 3.6e-25 87.9 0.6 3.9e-25 87.7 0.6 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad3 TAF6_C PF07571.13 AAS53352.1 - 2.3e-29 101.5 0.0 6.6e-29 100.1 0.0 1.8 1 0 0 1 1 1 1 TAF6 C-terminal HEAT repeat domain TAF PF02969.17 AAS53352.1 - 2.9e-27 94.6 0.2 6.3e-27 93.5 0.2 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) TFIID-31kDa PF02291.15 AAS53352.1 - 0.0035 17.4 0.1 0.0093 16.0 0.1 1.7 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 AAS53352.1 - 0.01 16.2 0.8 0.18 12.2 0.1 2.3 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 TAF4 PF05236.14 AAS53352.1 - 0.024 14.4 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family CENP-S PF15630.6 AAS53352.1 - 0.07 13.5 3.9 4.7 7.7 0.1 3.3 4 0 0 4 4 4 0 CENP-S protein CLASP_N PF12348.8 AAS53352.1 - 0.093 12.3 1.1 1.5 8.3 0.1 2.8 3 0 0 3 3 3 0 CLASP N terminal CBFD_NFYB_HMF PF00808.23 AAS53352.1 - 0.094 13.0 1.0 1.2 9.4 0.0 2.8 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF348 PF03990.14 AAS53352.1 - 0.098 12.4 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 G5-linked-Ubiquitin-like domain Sec7_N PF12783.7 AAS53352.1 - 0.11 12.4 5.5 13 5.7 0.0 3.4 1 1 1 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal SLD3 PF08639.10 AAS53353.1 - 2.4e-36 125.6 22.3 1.6e-27 96.5 14.7 2.3 1 1 1 2 2 2 2 DNA replication regulator SLD3 Sld3_N PF18523.1 AAS53353.1 - 1.7e-32 111.9 0.0 3.7e-32 110.9 0.0 1.6 1 0 0 1 1 1 1 Sld3 N-terminal domain GrpE PF01025.19 AAS53353.1 - 1.2 8.8 3.7 1.2 8.8 0.2 2.4 1 1 1 2 2 2 0 GrpE KH_1 PF00013.29 AAS53354.1 - 1.7e-37 127.0 6.2 2.6e-13 49.6 3.1 3.3 3 0 0 3 3 3 3 KH domain KH_2 PF07650.17 AAS53354.1 - 8.6e-11 41.5 1.6 0.054 13.3 0.0 3.4 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 AAS53354.1 - 0.00083 19.2 2.9 1 9.2 0.0 3.0 3 1 0 3 3 3 2 KH domain KH_5 PF13184.6 AAS53354.1 - 0.026 14.6 7.0 12 6.1 1.2 3.8 3 1 0 3 3 3 0 NusA-like KH domain MOEP19 PF16005.5 AAS53354.1 - 0.028 14.4 0.0 11 6.1 0.0 2.9 3 0 0 3 3 3 0 KH-like RNA-binding domain BCNT PF07572.12 AAS53355.1 - 3.9e-23 81.3 0.1 3.9e-23 81.3 0.1 2.0 2 0 0 2 2 2 1 Bucentaur or craniofacial development OPT PF03169.15 AAS53356.1 - 1.1e-151 506.5 22.3 1.3e-151 506.3 22.3 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4231 PF14015.6 AAS53356.1 - 0.023 15.2 0.6 5.8 7.4 0.2 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) CBS PF00571.28 AAS53357.1 - 2.7e-24 85.3 3.4 7.6e-10 39.1 0.1 4.2 4 0 0 4 4 4 4 CBS domain HTH_9 PF08221.11 AAS53357.1 - 0.44 10.7 2.1 3.8 7.7 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase III subunit RPC82 helix-turn-helix domain WD40 PF00400.32 AAS53358.1 - 1.3e-13 51.2 18.6 5.3e-05 23.9 0.3 6.8 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53358.1 - 1.2e-12 47.9 8.8 0.00064 20.0 0.7 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS53358.1 - 2.4e-07 30.0 0.3 2e-05 23.7 0.0 2.8 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AAS53358.1 - 1.6e-05 24.8 1.0 0.033 14.1 0.2 2.9 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A tRNA_int_endo PF01974.17 AAS53360.2 - 1.6e-12 47.3 0.1 2.7e-12 46.6 0.1 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain LisH PF08513.11 AAS53360.2 - 0.0096 15.9 0.8 0.02 14.8 0.8 1.6 1 0 0 1 1 1 1 LisH DUF3318 PF11780.8 AAS53360.2 - 0.038 13.9 0.1 0.07 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3318) Cation_ATPase_C PF00689.21 AAS53361.1 - 5.9e-41 140.2 2.7 5.9e-41 140.2 2.7 2.0 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 AAS53361.1 - 6.2e-40 136.6 0.2 2.1e-39 134.9 0.2 2.0 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 AAS53361.1 - 3e-16 59.3 0.0 7.2e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AAS53361.1 - 7.6e-15 55.8 0.3 2.2e-13 51.0 0.3 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AAS53361.1 - 3.4e-12 45.9 0.0 7.9e-12 44.7 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus DUF2207 PF09972.9 AAS53361.1 - 0.0024 16.7 0.2 0.049 12.4 0.0 2.6 3 0 0 3 3 3 1 Predicted membrane protein (DUF2207) Hydrolase_3 PF08282.12 AAS53361.1 - 0.023 14.4 1.4 0.042 13.6 0.8 1.7 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hanta_G1 PF01567.16 AAS53361.1 - 0.091 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Hantavirus glycoprotein G1 RskA PF10099.9 AAS53361.1 - 0.25 11.6 1.1 1.1 9.5 0.4 2.4 2 1 0 2 2 2 0 Anti-sigma-K factor rskA DUF948 PF06103.11 AAS53362.1 - 0.042 14.1 2.2 0.22 11.8 1.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF445 PF04286.12 AAS53362.1 - 0.044 13.6 2.5 0.06 13.2 0.2 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF445) Sporozoite_P67 PF05642.11 AAS53362.1 - 0.055 11.5 3.8 0.074 11.1 3.0 1.5 1 1 1 2 2 2 0 Sporozoite P67 surface antigen CLZ PF16526.5 AAS53362.1 - 0.075 13.4 6.1 0.66 10.4 0.3 4.0 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin_2 PF14523.6 AAS53362.1 - 0.089 13.2 5.2 0.13 12.7 2.1 2.6 2 1 1 3 3 3 0 Syntaxin-like protein Recep_L_domain PF01030.24 AAS53362.1 - 0.097 12.8 1.1 0.21 11.7 1.1 1.6 1 0 0 1 1 1 0 Receptor L domain TMF_TATA_bd PF12325.8 AAS53362.1 - 0.34 11.1 6.9 0.91 9.8 0.5 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 AAS53362.1 - 4.6 7.5 6.9 1.3 9.3 1.6 2.5 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 WD40 PF00400.32 AAS53363.1 - 6e-11 42.7 10.9 4.9e-05 24.0 0.5 4.8 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53363.1 - 6.9e-05 23.1 0.0 0.059 13.7 0.0 3.5 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Rep_fac-A_C PF08646.10 AAS53364.1 - 8.9e-56 187.7 15.2 1.6e-55 186.9 1.5 3.4 3 0 0 3 3 3 2 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 AAS53364.1 - 2.8e-33 113.7 1.7 4.5e-30 103.5 0.0 4.1 4 0 0 4 4 4 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 AAS53364.1 - 1.6e-17 63.2 3.4 5e-09 36.0 0.0 5.3 5 0 0 5 5 5 2 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AAS53364.1 - 1.5e-06 28.1 4.6 1.9e-05 24.5 0.0 3.6 3 1 0 3 3 2 1 Cell division control protein 24, OB domain 3 DDHD PF02862.17 AAS53364.1 - 0.00019 21.6 1.0 0.00039 20.6 1.0 1.6 1 0 0 1 1 1 1 DDHD domain Suf PF05843.14 AAS53364.1 - 0.0055 16.7 7.1 0.0092 16.0 7.1 1.4 1 0 0 1 1 1 1 Suppressor of forked protein (Suf) Rep-A_N PF04057.12 AAS53364.1 - 0.0063 16.5 1.0 0.016 15.2 0.0 2.2 3 0 0 3 3 1 1 Replication factor-A protein 1, N-terminal domain EPL1 PF10513.9 AAS53364.1 - 0.0069 16.8 5.1 0.0069 16.8 5.1 1.9 2 0 0 2 2 1 1 Enhancer of polycomb-like Coilin_N PF15862.5 AAS53364.1 - 0.017 14.9 4.5 0.045 13.6 4.5 1.7 1 0 0 1 1 1 0 Coilin N-terminus AIF_C PF14721.6 AAS53364.1 - 0.018 15.4 5.0 0.018 15.4 5.0 1.8 2 0 0 2 2 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CPSF100_C PF13299.6 AAS53364.1 - 0.03 14.5 3.6 0.06 13.5 3.6 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Pex14_N PF04695.13 AAS53364.1 - 0.053 14.2 16.1 0.13 12.9 16.1 1.7 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Spt20 PF12090.8 AAS53364.1 - 0.058 13.0 36.9 0.11 12.0 36.9 1.4 1 0 0 1 1 1 0 Spt20 family Med15 PF09606.10 AAS53364.1 - 0.059 12.1 27.9 0.09 11.4 27.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Neur_chan_memb PF02932.16 AAS53364.1 - 0.083 12.9 3.4 0.17 11.9 3.4 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SpoIIP PF07454.11 AAS53364.1 - 0.18 11.3 9.1 0.35 10.3 9.1 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 AAS53364.1 - 0.42 9.3 11.5 0.7 8.6 11.5 1.2 1 0 0 1 1 1 0 Presenilin MCU PF04678.13 AAS53364.1 - 0.51 10.4 7.0 0.13 12.4 3.6 1.7 2 0 0 2 2 1 0 Mitochondrial calcium uniporter Ndc1_Nup PF09531.10 AAS53364.1 - 0.52 8.9 9.9 0.78 8.4 9.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SprA-related PF12118.8 AAS53364.1 - 0.55 9.3 24.1 0.98 8.5 24.1 1.3 1 0 0 1 1 1 0 SprA-related family TERB2 PF15101.6 AAS53364.1 - 0.79 9.7 18.0 2 8.4 18.0 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 FAM101 PF15068.6 AAS53364.1 - 0.95 9.4 7.5 7.1 6.5 4.0 2.4 2 0 0 2 2 2 0 FAM101 family CobT PF06213.12 AAS53364.1 - 1.2 8.5 17.1 2.1 7.7 17.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PepSY_TM PF03929.16 AAS53364.1 - 1.3 8.7 3.4 2.3 7.8 3.4 1.4 1 0 0 1 1 1 0 PepSY-associated TM region Pet20 PF08692.10 AAS53364.1 - 2.1 9.1 5.9 4.7 7.9 2.6 2.8 3 0 0 3 3 2 0 Mitochondrial protein Pet20 MMU163 PF17119.5 AAS53364.1 - 2.1 7.4 8.5 1.4 8.1 5.4 1.9 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Roughex PF06020.11 AAS53364.1 - 2.2 7.3 11.3 4.3 6.3 11.3 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF4834 PF16118.5 AAS53364.1 - 2.3 9.2 17.2 1.7 9.7 14.7 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) DUF2722 PF10846.8 AAS53364.1 - 2.4 7.0 31.4 4 6.3 31.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Band_3_cyto PF07565.13 AAS53364.1 - 3.7 7.3 12.0 6.9 6.4 12.0 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Androgen_recep PF02166.16 AAS53364.1 - 5.6 5.7 27.6 9.4 4.9 27.6 1.3 1 0 0 1 1 1 0 Androgen receptor TMEM51 PF15345.6 AAS53364.1 - 5.9 6.7 11.9 11 5.7 11.9 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 Connexin PF00029.19 AAS53364.1 - 7.7 6.2 8.3 15 5.2 8.3 1.4 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 AAS53364.1 - 9.2 5.9 7.6 19 4.9 7.6 1.4 1 0 0 1 1 1 0 FAM176 family WD40 PF00400.32 AAS53365.2 - 6.1e-20 71.2 10.3 0.0013 19.5 0.0 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53365.2 - 2.3e-18 66.3 5.2 2.6e-09 37.2 0.3 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS53365.2 - 0.00067 19.6 0.1 0.82 9.5 0.0 2.7 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 AAS53366.1 - 1.2e-09 38.6 5.4 0.0071 17.2 1.3 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53366.1 - 1.9e-09 37.7 0.2 0.0014 18.9 0.0 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 AAS53366.1 - 0.00038 19.1 0.0 0.0009 17.9 0.0 1.7 1 1 0 1 1 1 1 Cytochrome D1 heme domain eIF2A PF08662.11 AAS53366.1 - 0.038 13.9 0.0 0.58 10.0 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Lgl_C PF08596.10 AAS53366.1 - 0.23 10.1 0.0 3.6 6.2 0.0 2.3 2 0 0 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal EMP24_GP25L PF01105.24 AAS53367.1 - 7.7e-47 159.6 0.1 9e-47 159.4 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD RE_AlwI PF09491.10 AAS53369.1 - 0.03 13.1 3.2 0.042 12.7 3.2 1.3 1 0 0 1 1 1 0 AlwI restriction endonuclease B-block_TFIIIC PF04182.12 AAS53370.2 - 1.3e-17 63.7 0.0 3.4e-17 62.4 0.0 1.8 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC AAA_assoc PF14363.6 AAS53370.2 - 0.0071 16.7 0.2 0.17 12.3 0.0 3.0 3 0 0 3 3 3 1 Domain associated at C-terminal with AAA N6-adenineMlase PF10237.9 AAS53371.1 - 8.1e-56 188.2 0.1 1.3e-55 187.6 0.1 1.3 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase IL28A PF15177.6 AAS53371.1 - 0.13 12.1 1.2 0.21 11.4 1.2 1.3 1 0 0 1 1 1 0 Interleukin-28A 3Beta_HSD PF01073.19 AAS53372.1 - 6.1e-87 291.2 0.0 7.5e-87 290.9 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AAS53372.1 - 3.1e-27 95.6 0.0 4.2e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 AAS53372.1 - 1.4e-16 60.8 0.0 4.3e-16 59.2 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 AAS53372.1 - 2.4e-13 49.8 0.0 5e-12 45.5 0.0 2.3 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 AAS53372.1 - 4.6e-10 39.1 0.0 7.3e-10 38.4 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_10 PF13460.6 AAS53372.1 - 1.3e-08 34.9 0.0 1.9e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AAS53372.1 - 1.8e-07 30.6 0.0 4.2e-07 29.4 0.0 1.6 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 AAS53372.1 - 0.011 15.6 0.0 0.081 12.8 0.0 2.2 1 1 0 1 1 1 0 KR domain NmrA PF05368.13 AAS53372.1 - 0.02 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 NmrA-like family Vps8 PF12816.7 AAS53373.1 - 3.6e-56 189.8 5.6 1.9e-53 180.9 2.6 2.5 2 0 0 2 2 2 2 Golgi CORVET complex core vacuolar protein 8 Clathrin PF00637.20 AAS53373.1 - 9.2e-08 32.1 5.5 3.7e-05 23.6 0.1 3.5 3 0 0 3 3 3 2 Region in Clathrin and VPS VWA_3 PF13768.6 AAS53373.1 - 0.0018 18.2 0.0 0.0041 17.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain zf-C3HC4 PF00097.25 AAS53373.1 - 0.0063 16.4 0.3 0.0063 16.4 0.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) ANAPC4_WD40 PF12894.7 AAS53373.1 - 0.016 15.5 0.0 4.1 7.8 0.0 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Lgl_C PF08596.10 AAS53373.1 - 0.021 13.5 0.0 0.064 12.0 0.0 1.7 1 1 1 2 2 2 0 Lethal giant larvae(Lgl) like, C-terminal zf-RING_11 PF17123.5 AAS53373.1 - 0.027 14.2 0.1 0.081 12.7 0.1 1.9 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_5 PF14634.6 AAS53373.1 - 0.054 13.5 1.9 0.26 11.3 1.9 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 AAS53373.1 - 0.055 13.8 0.4 0.055 13.8 0.4 2.9 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 AAS53373.1 - 0.32 10.9 3.9 0.17 11.7 0.7 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) EF1_GNE PF00736.19 AAS53374.1 - 8.6e-31 106.0 2.0 8.6e-31 106.0 2.0 1.8 2 0 0 2 2 2 1 EF-1 guanine nucleotide exchange domain EF-1_beta_acid PF10587.9 AAS53374.1 - 1.1e-12 48.2 4.1 1.1e-12 48.2 4.1 3.1 4 0 0 4 4 4 1 Eukaryotic elongation factor 1 beta central acidic region IFT57 PF10498.9 AAS53374.1 - 0.016 14.2 5.4 0.022 13.8 5.4 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 FAD_binding_5 PF00941.21 AAS53374.1 - 0.04 13.7 0.0 0.089 12.5 0.0 1.6 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase GST_C PF00043.25 AAS53374.1 - 0.36 11.1 3.4 1.7 8.9 0.5 2.7 2 1 0 2 2 2 0 Glutathione S-transferase, C-terminal domain SNF5 PF04855.12 AAS53375.1 - 1.2e-51 175.8 3.3 2.5e-30 106.0 0.1 2.2 1 1 1 2 2 2 2 SNF5 / SMARCB1 / INI1 PepX_N PF09168.10 AAS53375.1 - 0.28 11.6 3.9 0.42 11.0 1.1 2.1 1 1 0 2 2 2 0 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal CHD5 PF04420.14 AAS53377.1 - 5.1e-37 127.2 0.6 7.1e-37 126.7 0.6 1.3 1 0 0 1 1 1 1 CHD5-like protein OrfB_IS605 PF01385.19 AAS53377.1 - 0.028 14.6 1.1 0.056 13.7 1.1 1.5 1 0 0 1 1 1 0 Probable transposase DUF919 PF06034.11 AAS53377.1 - 0.085 12.7 4.0 1.2 9.0 0.1 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) UCH PF00443.29 AAS53378.2 - 5.8e-62 209.5 2.9 5.8e-62 209.5 2.9 2.3 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS53378.2 - 1.9e-16 60.5 9.4 5.3e-16 59.1 9.4 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AAS53378.2 - 8.8e-12 45.5 0.0 2.4e-11 44.1 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain zf-MIZ PF02891.20 AAS53378.2 - 0.00067 19.4 0.8 0.00067 19.4 0.8 2.4 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-4CXXC_R1 PF10497.9 AAS53378.2 - 8.2 6.7 7.9 1.9 8.8 1.6 2.6 2 0 0 2 2 2 0 Zinc-finger domain of monoamine-oxidase A repressor R1 BSD PF03909.17 AAS53379.1 - 1.1e-13 51.0 5.4 3.3e-13 49.4 0.1 2.8 2 1 0 2 2 2 1 BSD domain Y_phosphatase2 PF03162.13 AAS53380.1 - 5.4e-55 185.4 0.4 6.6e-55 185.2 0.4 1.1 1 0 0 1 1 1 1 Tyrosine phosphatase family Phage_glycop_gL PF11108.8 AAS53380.1 - 0.0053 16.8 0.1 0.0089 16.1 0.1 1.3 1 0 0 1 1 1 1 Viral glycoprotein L Y_phosphatase3 PF13350.6 AAS53380.1 - 0.19 11.6 0.0 0.21 11.5 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Asp_protease PF09668.10 AAS53381.1 - 3.4e-53 178.7 0.1 5.5e-53 178.0 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 AAS53381.1 - 2e-21 76.4 0.1 5e-21 75.1 0.1 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AAS53381.1 - 1.1e-10 42.0 0.1 3.1e-10 40.6 0.1 1.8 1 0 0 1 1 1 1 Aspartyl protease UBA PF00627.31 AAS53381.1 - 2.3e-05 24.2 0.2 5.7e-05 22.9 0.2 1.7 1 0 0 1 1 1 1 UBA/TS-N domain RVP_2 PF08284.11 AAS53381.1 - 0.00016 21.4 0.0 0.00036 20.3 0.0 1.5 1 0 0 1 1 1 1 Retroviral aspartyl protease RVP PF00077.20 AAS53381.1 - 0.00044 20.5 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 Retroviral aspartyl protease TPPII_N PF12583.8 AAS53381.1 - 0.5 11.0 10.3 1.4 9.5 10.3 1.7 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal HhH-GPD PF00730.25 AAS53382.1 - 5.2e-10 39.7 0.0 8.3e-10 39.1 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein baeRF_family3 PF18845.1 AAS53382.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 Glyco_transf_21 PF13506.6 AAS53382.1 - 0.11 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 21 COX15-CtaA PF02628.15 AAS53383.1 - 1.5e-119 398.8 4.5 1.8e-119 398.6 4.5 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein 7TMR-DISM_7TM PF07695.11 AAS53383.1 - 0.48 10.3 9.0 0.1 12.5 1.0 2.8 3 0 0 3 3 3 0 7TM diverse intracellular signalling Lon_C PF05362.13 AAS53384.2 - 5.3e-65 218.8 0.0 1.1e-64 217.8 0.0 1.5 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain LON_substr_bdg PF02190.16 AAS53384.2 - 6.3e-41 140.6 0.0 1.4e-40 139.4 0.0 1.6 1 0 0 1 1 1 1 ATP-dependent protease La (LON) substrate-binding domain AAA PF00004.29 AAS53384.2 - 5.9e-22 78.5 0.0 1.5e-21 77.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AAS53384.2 - 1.9e-08 34.4 0.0 3.5e-07 30.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ChlI PF13541.6 AAS53384.2 - 1.1e-06 28.4 0.0 3.3e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase AAA_2 PF07724.14 AAS53384.2 - 1.7e-05 25.0 0.0 5e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AAS53384.2 - 5.2e-05 23.5 0.1 0.0016 18.7 0.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 AAS53384.2 - 6.7e-05 22.0 1.0 9.5e-05 21.5 0.0 1.6 2 0 0 2 2 2 1 PrkA AAA domain AAA_16 PF13191.6 AAS53384.2 - 0.00039 20.8 0.2 0.014 15.8 0.1 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 AAS53384.2 - 0.00067 20.2 0.0 0.0024 18.4 0.0 2.0 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AAS53384.2 - 0.0011 18.7 0.0 0.0061 16.3 0.0 2.3 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 AAS53384.2 - 0.0073 16.1 0.0 0.019 14.7 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein NTPase_1 PF03266.15 AAS53384.2 - 0.03 14.2 0.1 0.87 9.5 0.0 2.5 1 1 1 2 2 2 0 NTPase AAA_14 PF13173.6 AAS53384.2 - 0.03 14.3 0.0 0.073 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AAS53384.2 - 0.036 14.0 0.1 0.22 11.4 0.1 2.1 1 1 0 1 1 1 0 NACHT domain TIP49 PF06068.13 AAS53384.2 - 0.036 13.3 0.1 0.036 13.3 0.1 1.9 2 0 0 2 2 2 0 TIP49 P-loop domain RsgA_GTPase PF03193.16 AAS53384.2 - 0.043 13.7 0.0 0.12 12.3 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NB-ARC PF00931.22 AAS53384.2 - 0.074 12.2 0.1 0.15 11.2 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.22 AAS53384.2 - 0.18 12.2 0.0 0.41 11.1 0.0 1.6 1 0 0 1 1 1 0 RNA helicase SKI PF01202.22 AAS53384.2 - 0.65 10.1 0.0 0.65 10.1 0.0 2.5 4 0 0 4 4 2 0 Shikimate kinase CBFD_NFYB_HMF PF00808.23 AAS53385.1 - 1.9e-25 88.9 0.0 2.7e-25 88.4 0.0 1.2 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AAS53385.1 - 6.2e-05 23.4 0.1 0.0001 22.7 0.1 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AAS53385.1 - 0.016 15.3 0.0 0.022 14.9 0.0 1.3 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold Bromo_TP PF07524.13 AAS53385.1 - 0.029 14.4 0.0 0.3 11.1 0.0 2.1 2 0 0 2 2 2 0 Bromodomain associated TFIID_20kDa PF03847.13 AAS53385.1 - 0.032 14.7 0.4 0.15 12.6 0.1 2.0 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Rft-1 PF04506.13 AAS53386.1 - 2.7e-205 682.9 32.9 3.1e-205 682.8 32.9 1.0 1 0 0 1 1 1 1 Rft protein Exo_endo_phos PF03372.23 AAS53387.1 - 4.9e-15 55.7 0.0 1.1e-14 54.5 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family zf-GRF PF06839.12 AAS53387.1 - 5.8e-11 42.3 1.5 1.2e-10 41.3 1.5 1.6 1 0 0 1 1 1 1 GRF zinc finger PI-PLC-C1 PF16670.5 AAS53387.1 - 0.15 11.1 0.1 0.23 10.5 0.1 1.2 1 0 0 1 1 1 0 Phosphoinositide phospholipase C, Ca2+-dependent Sortilin-Vps10 PF15902.5 AAS53389.2 - 6e-180 598.8 1.4 1.1e-129 433.2 0.1 2.1 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, Sortilin_C PF15901.5 AAS53389.2 - 1.3e-58 198.1 12.4 6.4e-36 124.3 3.1 2.3 2 0 0 2 2 2 2 Sortilin, neurotensin receptor 3, C-terminal BNR PF02012.20 AAS53389.2 - 2.9e-12 44.6 35.8 0.53 10.5 0.1 13.2 13 0 0 13 13 13 7 BNR/Asp-box repeat BNR_2 PF13088.6 AAS53389.2 - 2.2e-07 30.5 0.5 0.23 10.7 0.0 6.0 5 2 1 6 6 6 2 BNR repeat-like domain CHB_HEX_C PF03174.13 AAS53389.2 - 0.016 15.1 0.6 16 5.5 0.0 3.6 2 1 1 3 3 3 0 Chitobiase/beta-hexosaminidase C-terminal domain Pkinase PF00069.25 AAS53390.1 - 3.2e-66 223.4 0.0 3.9e-66 223.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53390.1 - 1e-30 106.9 0.0 1.3e-30 106.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS53390.1 - 0.003 16.6 0.6 0.0085 15.1 0.6 1.7 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 AAS53390.1 - 0.019 14.3 0.1 0.039 13.3 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 AAS53390.1 - 0.03 13.9 0.0 0.05 13.2 0.0 1.3 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 AAS53390.1 - 0.046 13.6 1.6 0.072 13.0 0.2 2.0 2 1 0 2 2 2 0 Phosphotransferase enzyme family FTA2 PF13095.6 AAS53390.1 - 0.048 13.3 0.1 0.087 12.4 0.1 1.5 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 AAS53390.1 - 0.059 12.7 0.0 0.098 12.0 0.0 1.4 1 0 0 1 1 1 0 Kinase-like AcetylCoA_hydro PF02550.15 AAS53391.2 - 3.7e-61 206.6 0.0 7.8e-61 205.5 0.0 1.5 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase N-terminal domain AcetylCoA_hyd_C PF13336.6 AAS53391.2 - 7.5e-41 139.6 0.0 1.3e-40 138.8 0.0 1.4 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase C-terminal domain CitF PF04223.12 AAS53391.2 - 0.0016 17.4 0.1 0.0044 16.0 0.0 1.6 2 0 0 2 2 2 1 Citrate lyase, alpha subunit (CitF) CoA_trans PF01144.23 AAS53391.2 - 0.12 11.7 0.0 0.99 8.8 0.0 2.5 3 0 0 3 3 3 0 Coenzyme A transferase ANAPC1 PF12859.7 AAS53392.1 - 1.2e-08 35.6 0.1 5.3e-08 33.5 0.1 2.2 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 1 PC_rep PF01851.22 AAS53392.1 - 0.0035 17.7 0.2 0.23 12.0 0.0 3.3 3 0 0 3 3 3 1 Proteasome/cyclosome repeat PS_Dcarbxylase PF02666.15 AAS53393.1 - 5.1e-70 235.1 0.0 1.9e-68 230.0 0.0 2.1 1 1 0 1 1 1 1 Phosphatidylserine decarboxylase NADH_oxidored PF08040.11 AAS53393.1 - 0.11 12.2 0.0 0.33 10.7 0.0 1.8 1 0 0 1 1 1 0 MNLL subunit dCMP_cyt_deam_1 PF00383.23 AAS53394.1 - 4.4e-26 90.7 3.9 7.2e-26 90.0 3.9 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AAS53394.1 - 4.1e-12 46.0 0.3 6.2e-12 45.4 0.3 1.2 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC4_like PF18774.1 AAS53394.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase FAA_hydrolase PF01557.18 AAS53395.1 - 5.1e-57 193.0 0.0 5.9e-57 192.8 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FixP_N PF14715.6 AAS53395.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP bZIP_1 PF00170.21 AAS53396.2 - 1.2e-08 34.9 1.2 2.6e-08 33.8 1.2 1.5 1 0 0 1 1 1 1 bZIP transcription factor Aft1_OSA PF11785.8 AAS53396.2 - 4.5e-07 30.2 0.3 1.7e-06 28.3 0.3 2.0 1 0 0 1 1 1 1 Aft1 osmotic stress response (OSM) domain bZIP_2 PF07716.15 AAS53396.2 - 6e-05 23.0 2.0 6e-05 23.0 2.0 2.5 2 0 0 2 2 2 1 Basic region leucine zipper Aft1_HRA PF11786.8 AAS53396.2 - 0.00085 19.6 14.2 0.00085 19.6 14.2 4.1 2 1 2 4 4 4 1 Aft1 HRA domain Macoilin PF09726.9 AAS53396.2 - 0.013 14.1 8.5 0.017 13.7 8.5 1.1 1 0 0 1 1 1 0 Macoilin family DNA_RNApol_7kD PF03604.13 AAS53397.1 - 2.7e-16 59.0 2.0 3.5e-16 58.6 2.0 1.2 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.7 AAS53397.1 - 0.0058 16.6 0.4 0.008 16.2 0.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon TFIIS_C PF01096.18 AAS53397.1 - 0.012 15.4 0.9 2.4 8.1 0.1 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) HypA PF01155.19 AAS53397.1 - 0.018 15.1 0.2 0.018 15.1 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_ribbon_SprT PF17283.2 AAS53397.1 - 0.025 14.5 2.6 0.038 13.9 2.2 1.6 1 1 0 1 1 1 0 SprT-like zinc ribbon domain zinc_ribbon_10 PF10058.9 AAS53397.1 - 0.025 14.3 0.3 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein TF_Zn_Ribbon PF08271.12 AAS53397.1 - 0.031 13.8 0.3 4.9 6.8 0.0 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding zinc-ribbons_6 PF07191.12 AAS53397.1 - 0.031 14.2 0.4 0.041 13.9 0.4 1.3 1 0 0 1 1 1 0 zinc-ribbons zf_UBZ PF18439.1 AAS53397.1 - 0.047 13.3 0.5 4.2 7.0 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger MCM_OB PF17207.3 AAS53397.1 - 0.051 13.4 0.2 0.06 13.2 0.2 1.1 1 0 0 1 1 1 0 MCM OB domain DUF2318 PF10080.9 AAS53397.1 - 0.057 13.5 0.1 0.062 13.4 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Zn-ribbon_8 PF09723.10 AAS53397.1 - 0.53 10.5 3.6 2.4 8.3 3.6 2.0 1 1 1 2 2 2 0 Zinc ribbon domain zinc_ribbon_4 PF13717.6 AAS53397.1 - 0.66 9.9 5.0 3.1 7.8 5.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 AAS53397.1 - 1.5 8.6 5.1 3.3 7.5 0.6 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain BORCS6 PF10157.9 AAS53398.2 - 0.061 13.6 0.1 0.061 13.6 0.1 1.9 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 6 Siah-Interact_N PF09032.11 AAS53398.2 - 0.2 12.0 4.2 6.1 7.2 0.5 2.9 2 2 0 2 2 2 0 Siah interacting protein, N terminal Amidase02_C PF12123.8 AAS53398.2 - 0.21 11.3 0.3 0.38 10.5 0.3 1.4 1 0 0 1 1 1 0 N-acetylmuramoyl-l-alanine amidase MYO10_CC PF16735.5 AAS53398.2 - 1.8 8.7 4.2 2.8 8.1 0.1 2.6 3 0 0 3 3 3 0 Unconventional myosin-X coiled coil domain Vac_Fusion PF02346.16 AAS53398.2 - 2.5 7.8 4.5 51 3.6 0.1 3.5 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Svs_4_5_6 PF17381.2 AAS53398.2 - 5.4 8.0 10.1 3 8.9 3.9 2.6 2 0 0 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 TMF_TATA_bd PF12325.8 AAS53398.2 - 6 7.1 7.9 11 6.2 1.4 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Mito_fiss_reg PF05308.11 AAS53398.2 - 7.1 6.6 10.5 4.9 7.2 5.5 2.4 1 1 1 2 2 2 0 Mitochondrial fission regulator CKS PF01111.19 AAS53401.1 - 0.13 12.6 0.0 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Cyclin-dependent kinase regulatory subunit GTP_EFTU PF00009.27 AAS53402.2 - 4.1e-58 196.1 0.0 6.7e-58 195.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_C PF00679.24 AAS53402.2 - 7.5e-15 54.7 0.1 2.4e-14 53.1 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AAS53402.2 - 1.8e-11 44.3 0.0 5.1e-11 42.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 AAS53402.2 - 6.6e-08 32.5 0.0 1.3e-07 31.6 0.0 1.6 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_IV PF03764.18 AAS53402.2 - 0.00034 20.4 0.0 0.00099 18.9 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G, domain IV MMR_HSR1 PF01926.23 AAS53402.2 - 0.024 14.7 0.0 0.071 13.2 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase TRAF6_Z2 PF18048.1 AAS53403.1 - 0.012 15.7 6.8 1.2 9.3 2.1 2.2 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 MNNL PF07657.13 AAS53403.1 - 0.046 13.8 1.2 0.06 13.4 1.2 1.2 1 0 0 1 1 1 0 N terminus of Notch ligand TM1506 PF08973.10 AAS53403.1 - 0.079 12.6 0.0 0.093 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) IBR PF01485.21 AAS53403.1 - 0.43 10.8 5.0 0.28 11.4 0.5 2.1 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain DNA_ligase_ZBD PF03119.16 AAS53403.1 - 2.2 8.4 6.8 2.3 8.3 5.0 2.0 2 1 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Chs7 PF12271.8 AAS53404.1 - 1.7e-106 355.8 17.5 1.9e-106 355.6 17.5 1.0 1 0 0 1 1 1 1 Chitin synthase export chaperone Ribosomal_L44 PF00935.19 AAS53405.1 - 6e-35 119.6 11.4 9.2e-35 119.0 11.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L44 Pkinase PF00069.25 AAS53406.1 - 4.6e-62 209.8 0.5 8.5e-42 143.3 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53406.1 - 7.3e-27 94.3 0.4 1.6e-20 73.5 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS53406.1 - 1.9e-05 23.8 1.0 5.9e-05 22.2 0.2 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 AAS53406.1 - 0.0021 17.5 0.6 0.0061 15.9 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS53406.1 - 0.0023 17.9 0.1 0.67 9.8 0.1 2.6 1 1 1 2 2 2 2 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 AAS53406.1 - 0.039 13.0 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 Pkinase_fungal PF17667.1 AAS53406.1 - 0.056 12.2 0.0 0.098 11.4 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 AAS53406.1 - 0.14 11.5 0.0 0.14 11.5 0.0 2.1 2 1 0 2 2 2 0 Kinase-like Far-17a_AIG1 PF04750.14 AAS53407.1 - 1.4e-12 47.4 4.5 1.8e-12 47.0 4.5 1.1 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Ammonium_transp PF00909.21 AAS53408.2 - 5.9e-111 371.0 26.8 7.2e-111 370.7 26.8 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Prefoldin_2 PF01920.20 AAS53410.2 - 9.9e-25 86.6 8.2 1.2e-24 86.3 8.2 1.1 1 0 0 1 1 1 1 Prefoldin subunit PP2C_2 PF13672.6 AAS53410.2 - 0.024 14.3 0.2 0.028 14.0 0.2 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C RSS_P20 PF11757.8 AAS53410.2 - 0.026 14.9 0.2 0.065 13.7 0.1 1.7 2 0 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain MCR_D PF02505.14 AAS53410.2 - 0.042 13.7 0.1 0.062 13.2 0.1 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase operon protein D DivIC PF04977.15 AAS53410.2 - 0.25 11.1 11.1 1.7 8.5 1.0 2.2 2 0 0 2 2 2 0 Septum formation initiator JHY PF15261.6 AAS53410.2 - 0.62 10.8 4.6 0.93 10.2 0.6 2.1 2 0 0 2 2 2 0 Jhy protein APG6_N PF17675.1 AAS53410.2 - 2.1 8.9 17.9 2 8.9 7.4 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Pkinase PF00069.25 AAS53411.1 - 2e-23 83.1 1.8 3.5e-23 82.3 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53411.1 - 4.1e-12 45.9 0.0 1.5e-11 44.1 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS53411.1 - 3.1e-09 36.1 7.0 4.2e-09 35.7 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase TFIIA PF03153.13 AAS53411.1 - 0.00091 19.3 26.2 0.00091 19.3 26.2 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit zf-AN1 PF01428.16 AAS53412.1 - 8e-10 38.7 12.0 1.4e-09 38.0 12.0 1.3 1 0 0 1 1 1 1 AN1-like Zinc finger zf-CRD PF17979.1 AAS53412.1 - 0.38 10.8 6.7 1.2 9.2 6.7 2.1 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions WLM PF08325.10 AAS53413.2 - 2.5e-56 190.8 4.2 3.4e-55 187.1 4.2 1.9 1 1 0 1 1 1 1 WLM domain DUF45 PF01863.17 AAS53413.2 - 0.046 13.8 0.0 0.07 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF45 MPTase-PolyVal PF18818.1 AAS53413.2 - 0.18 11.9 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Metallopeptidase superfamily domain INSIG PF07281.12 AAS53414.1 - 8.9e-17 61.4 11.8 2.9e-14 53.2 11.8 3.0 1 1 0 1 1 1 1 Insulin-induced protein (INSIG) MNHE PF01899.16 AAS53414.1 - 0.26 11.1 2.4 0.47 10.2 2.4 1.4 1 0 0 1 1 1 0 Na+/H+ ion antiporter subunit Endosulfine PF04667.17 AAS53415.1 - 9e-31 105.9 0.1 1.3e-30 105.3 0.1 1.3 1 0 0 1 1 1 1 cAMP-regulated phosphoprotein/endosulfine conserved region Peptidase_M14 PF00246.24 AAS53416.1 - 1.2e-76 258.3 0.0 1.4e-76 258.0 0.0 1.1 1 0 0 1 1 1 1 Zinc carboxypeptidase Pga1 PF10333.9 AAS53417.1 - 1.8e-57 194.0 0.0 2.1e-57 193.8 0.0 1.0 1 0 0 1 1 1 1 GPI-Mannosyltransferase II co-activator Qn_am_d_aII PF14930.6 AAS53417.1 - 0.06 13.7 0.0 0.099 13.0 0.0 1.3 1 0 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain II Arginase PF00491.21 AAS53419.2 - 1.6e-82 277.2 0.2 1.9e-82 276.9 0.2 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 AAS53419.2 - 0.0089 16.3 0.6 0.014 15.6 0.6 1.2 1 0 0 1 1 1 1 UPF0489 domain RRXRR PF14239.6 AAS53420.1 - 0.064 13.1 1.5 0.13 12.1 1.5 1.4 1 0 0 1 1 1 0 RRXRR protein Cwf_Cwc_15 PF04889.12 AAS53420.1 - 1.4 8.5 8.9 3 7.5 8.9 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 AAS53420.1 - 1.7 8.6 6.2 2.7 7.9 6.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PPP4R2 PF09184.11 AAS53420.1 - 1.8 8.1 6.7 2.6 7.6 6.7 1.1 1 0 0 1 1 1 0 PPP4R2 DUF2009 PF09418.10 AAS53421.1 - 3.4e-207 689.0 0.1 4e-207 688.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2009) zf-B_box PF00643.24 AAS53421.1 - 0.00011 22.2 4.1 0.00021 21.3 4.1 1.4 1 0 0 1 1 1 1 B-box zinc finger CEBP_ZZ PF16366.5 AAS53421.1 - 0.0045 17.2 4.5 0.0095 16.1 4.5 1.5 1 0 0 1 1 1 1 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-C3HC4_3 PF13920.6 AAS53421.1 - 0.038 13.9 5.9 0.07 13.0 5.9 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 AAS53421.1 - 0.1 12.8 4.8 0.081 13.2 2.3 2.1 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Actin PF00022.19 AAS53422.2 - 1.9e-119 398.9 0.0 8.3e-119 396.8 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AAS53422.2 - 0.033 13.0 0.0 2.7 6.7 0.0 2.7 2 1 0 2 2 2 0 MreB/Mbl protein UPRTase PF14681.6 AAS53423.1 - 8.3e-76 254.0 0.0 1.1e-75 253.6 0.0 1.0 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 AAS53423.1 - 0.004 16.7 0.0 0.0055 16.2 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain CoA_binding_2 PF13380.6 AAS53423.1 - 0.081 13.4 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 CoA binding domain LSM PF01423.22 AAS53424.2 - 1e-20 73.1 0.1 1.2e-20 72.9 0.1 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AAS53424.2 - 0.023 14.4 0.1 0.033 13.8 0.1 1.2 1 0 0 1 1 1 0 Hfq protein CAP_GLY PF01302.25 AAS53425.2 - 7.8e-20 70.7 2.3 8.4e-20 70.6 0.5 2.0 2 0 0 2 2 2 1 CAP-Gly domain Ubiquitin_2 PF14560.6 AAS53425.2 - 0.033 14.6 0.0 0.077 13.5 0.0 1.6 2 0 0 2 2 2 0 Ubiquitin-like domain PGA2 PF07543.12 AAS53426.1 - 9.8e-12 45.0 7.3 1.7e-05 24.8 3.0 2.0 1 1 1 2 2 2 2 Protein trafficking PGA2 LapA_dom PF06305.11 AAS53426.1 - 4.7 7.1 7.8 3 7.7 1.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain RNA_pol_3_Rpc31 PF11705.8 AAS53427.1 - 5.7e-52 177.2 7.7 7.1e-52 176.9 7.7 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 VasL PF12486.8 AAS53427.1 - 0.26 11.2 0.0 0.38 10.6 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL C2 PF00168.30 AAS53428.2 - 9.3e-13 48.4 0.0 1.6e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 C2 domain THOC2_N PF16134.5 AAS53429.2 - 2.1e-142 476.0 0.0 4.7e-142 474.8 0.0 1.6 1 0 0 1 1 1 1 THO complex subunit 2 N-terminus Tho2 PF11262.8 AAS53429.2 - 3.4e-38 131.6 3.3 2.7e-25 89.2 1.7 3.1 1 1 1 2 2 2 2 Transcription factor/nuclear export subunit protein 2 Thoc2 PF11732.8 AAS53429.2 - 1.5e-20 73.0 0.0 4.6e-20 71.5 0.0 1.9 1 0 0 1 1 1 1 Transcription- and export-related complex subunit SF3b10 PF07189.11 AAS53430.1 - 6.8e-27 93.4 0.0 7.9e-27 93.2 0.0 1.0 1 0 0 1 1 1 1 Splicing factor 3B subunit 10 (SF3b10) Pox_P4B PF03292.14 AAS53430.1 - 0.1 10.8 0.0 0.11 10.7 0.0 1.0 1 0 0 1 1 1 0 Poxvirus P4B major core protein CAP_N PF01213.19 AAS53432.2 - 6.8e-102 341.2 0.7 1e-101 340.6 0.0 1.6 1 1 1 2 2 2 1 Adenylate cyclase associated (CAP) N terminal CAP_C PF08603.11 AAS53432.2 - 1.8e-59 199.9 0.2 2.3e-59 199.5 0.2 1.1 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 AAS53432.2 - 0.02 14.7 1.3 0.034 13.9 1.3 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor C DEC-1_N PF04625.13 AAS53432.2 - 3.8 6.4 11.2 0.81 8.6 7.0 1.9 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region S4 PF01479.25 AAS53433.1 - 4e-14 52.1 0.0 7.5e-14 51.2 0.0 1.5 1 0 0 1 1 1 1 S4 domain Prp19 PF08606.11 AAS53433.1 - 0.053 13.5 0.1 0.18 11.8 0.1 1.9 1 0 0 1 1 1 0 Prp19/Pso4-like DUF2605 PF10792.9 AAS53433.1 - 0.089 12.7 0.2 1.8 8.5 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2605) S4_2 PF13275.6 AAS53433.1 - 0.13 12.1 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 S4 domain Eaf7 PF07904.13 AAS53434.1 - 3e-29 101.5 0.0 6.8e-29 100.4 0.0 1.6 1 0 0 1 1 1 1 Chromatin modification-related protein EAF7 FKBP_C PF00254.28 AAS53435.1 - 3.3e-33 113.9 0.0 3.9e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase PIR PF00399.19 AAS53436.2 - 1.3e-06 27.8 3.7 5.2e-06 25.9 3.7 2.2 1 0 0 1 1 1 1 Yeast PIR protein repeat ADH_zinc_N PF00107.26 AAS53437.2 - 5.1e-09 36.2 0.0 7.9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AAS53437.2 - 0.0029 17.5 0.0 0.034 14.0 0.0 2.2 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AAS53437.2 - 0.12 13.4 0.0 0.3 12.1 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Cpn60_TCP1 PF00118.24 AAS53438.1 - 1.9e-158 528.1 3.4 2.2e-158 527.9 3.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Pyr_redox_2 PF07992.14 AAS53438.1 - 0.057 12.6 0.1 0.12 11.6 0.1 1.5 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Dak2 PF02734.17 AAS53438.1 - 0.15 12.0 1.3 2.8 7.8 0.1 2.7 2 1 0 2 2 2 0 DAK2 domain Snf7 PF03357.21 AAS53439.1 - 2.8e-10 40.1 15.8 4.1e-10 39.5 15.8 1.2 1 0 0 1 1 1 1 Snf7 BORCS7 PF16088.5 AAS53439.1 - 0.0031 17.8 1.4 0.0031 17.8 1.4 2.0 1 1 0 2 2 2 1 BLOC-1-related complex sub-unit 7 DASH_Dad2 PF08654.10 AAS53439.1 - 0.02 15.3 2.0 0.02 15.3 2.0 2.8 1 1 3 4 4 4 0 DASH complex subunit Dad2 Med28 PF11594.8 AAS53439.1 - 0.028 14.5 3.2 0.029 14.4 2.0 1.6 1 1 0 1 1 1 0 Mediator complex subunit 28 DMSP_lyase PF16867.5 AAS53439.1 - 0.061 13.0 0.5 0.13 11.9 0.1 1.7 2 0 0 2 2 2 0 Dimethlysulfonioproprionate lyase Baculo_PEP_C PF04513.12 AAS53439.1 - 0.065 13.3 4.0 0.041 13.9 1.5 1.8 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus T2SSM PF04612.12 AAS53439.1 - 0.11 12.5 9.5 0.21 11.7 0.4 2.4 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M APG6_N PF17675.1 AAS53439.1 - 0.16 12.5 11.5 1.8 9.1 1.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region ECH_2 PF16113.5 AAS53439.1 - 0.41 10.1 5.8 0.52 9.7 5.8 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase DUF948 PF06103.11 AAS53439.1 - 0.77 10.1 10.9 0.53 10.6 1.6 2.8 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Dak2 PF02734.17 AAS53439.1 - 5.6 6.8 9.6 2.2 8.1 1.6 2.5 1 1 2 3 3 3 0 DAK2 domain GATA PF00320.27 AAS53440.2 - 5.9e-16 57.8 3.1 1e-15 57.0 3.1 1.4 1 0 0 1 1 1 1 GATA zinc finger DUF2387 PF09526.10 AAS53440.2 - 7.4e-05 22.8 0.1 0.00019 21.5 0.1 1.6 2 0 0 2 2 2 1 Probable metal-binding protein (DUF2387) TF_Zn_Ribbon PF08271.12 AAS53440.2 - 0.017 14.6 0.3 0.031 13.8 0.3 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding Elf1 PF05129.13 AAS53440.2 - 0.1 12.7 0.1 0.25 11.4 0.1 1.6 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DOPA_dioxygen PF08883.11 AAS53441.1 - 2.7e-24 85.4 0.0 3.2e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Dopa 4,5-dioxygenase family PLDc PF00614.22 AAS53442.2 - 4.4e-16 58.3 0.7 1.7e-07 31.2 0.3 3.0 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 AAS53442.2 - 7.9e-13 48.4 0.1 1.1e-07 31.8 0.1 3.5 2 1 0 2 2 2 2 PLD-like domain PX PF00787.24 AAS53442.2 - 4.1e-05 23.5 4.0 0.052 13.5 0.3 3.8 3 0 0 3 3 3 2 PX domain UNC-50 PF05216.13 AAS53444.1 - 6.2e-84 281.0 20.0 6.9e-84 280.8 20.0 1.0 1 0 0 1 1 1 1 UNC-50 family BP28CT PF08146.12 AAS53445.1 - 3.3e-36 124.5 9.4 5e-36 123.9 4.6 3.4 2 0 0 2 2 2 1 BP28CT (NUC211) domain U3snoRNP10 PF12397.8 AAS53445.1 - 7.2e-19 68.2 2.6 7.2e-19 68.2 2.6 6.7 8 1 0 8 8 8 2 U3 small nucleolar RNA-associated protein 10 HEAT_2 PF13646.6 AAS53445.1 - 0.0037 17.6 2.7 8.4 6.9 0.0 5.1 5 0 0 5 5 5 2 HEAT repeats DUF1957 PF09210.11 AAS53445.1 - 0.021 15.2 0.4 0.084 13.3 0.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1957) HEAT_EZ PF13513.6 AAS53445.1 - 0.046 14.2 1.1 9.7 6.8 0.1 4.2 4 0 0 4 4 4 0 HEAT-like repeat ThrE PF06738.12 AAS53446.1 - 2e-69 233.6 21.6 4.7e-66 222.6 7.6 2.3 2 0 0 2 2 2 2 Putative threonine/serine exporter ThrE_2 PF12821.7 AAS53446.1 - 1.3e-12 48.0 11.6 1.3e-12 48.0 11.6 2.4 2 0 0 2 2 2 1 Threonine/Serine exporter, ThrE Pkinase PF00069.25 AAS53447.1 - 1e-50 172.6 0.1 8.1e-49 166.3 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53447.1 - 1e-26 93.8 0.1 6.3e-26 91.2 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 AAS53447.1 - 0.002 17.5 0.2 0.0037 16.6 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Dicty_REP PF05086.12 AAS53447.1 - 0.0032 15.6 25.7 0.084 10.8 6.8 2.2 2 0 0 2 2 2 2 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 AAS53447.1 - 0.031 14.3 43.6 0.29 11.1 7.2 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein FSA_C PF10479.9 AAS53447.1 - 7.4 4.6 26.0 0.41 8.7 4.3 2.2 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus PHD PF00628.29 AAS53448.2 - 5.4e-10 39.0 8.1 1.1e-09 38.0 8.1 1.5 1 0 0 1 1 1 1 PHD-finger SET PF00856.28 AAS53448.2 - 1.4e-05 25.5 0.0 5.3e-05 23.7 0.0 2.1 1 1 0 1 1 1 1 SET domain PHD_2 PF13831.6 AAS53448.2 - 0.00024 20.6 3.0 0.00055 19.4 3.0 1.6 1 0 0 1 1 1 1 PHD-finger Sec3-PIP2_bind PF15277.6 AAS53448.2 - 0.0089 16.1 0.3 0.13 12.4 0.0 2.8 3 0 0 3 3 3 1 Exocyst complex component SEC3 N-terminal PIP2 binding PH zf-CW PF07496.15 AAS53448.2 - 0.52 10.4 4.6 0.57 10.3 1.9 2.3 2 0 0 2 2 2 0 CW-type Zinc Finger Pam16 PF03656.13 AAS53449.2 - 3.6e-47 159.5 0.2 4.1e-47 159.3 0.2 1.0 1 0 0 1 1 1 1 Pam16 NTP_transferase PF00483.23 AAS53449.2 - 0.047 13.3 0.0 0.053 13.1 0.0 1.1 1 0 0 1 1 1 0 Nucleotidyl transferase Closter_coat PF01785.17 AAS53449.2 - 0.13 11.6 0.1 0.2 10.9 0.1 1.2 1 0 0 1 1 1 0 Closterovirus coat protein zf_CCCH_4 PF18345.1 AAS53450.1 - 0.045 13.8 11.5 1 9.5 2.2 5.1 4 1 0 4 4 4 0 Zinc finger domain zf-CCCH PF00642.24 AAS53450.1 - 0.049 13.6 37.1 0.18 11.8 3.3 5.7 5 1 1 6 6 6 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_2 PF14608.6 AAS53450.1 - 6 7.5 17.2 6.7 7.4 2.6 3.7 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger zf-C2HC5 PF06221.13 AAS53451.1 - 1.4e-20 73.0 9.9 2.5e-20 72.2 9.9 1.4 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type DUF1481 PF07356.12 AAS53451.1 - 0.023 14.4 0.6 0.057 13.2 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1481) MmoB_DmpM PF02406.17 AAS53451.1 - 0.051 13.8 0.0 0.14 12.4 0.0 1.8 1 0 0 1 1 1 0 MmoB/DmpM family 4F5 PF04419.14 AAS53451.1 - 4.3 8.3 15.6 1.2 10.1 1.0 3.7 3 0 0 3 3 3 0 4F5 protein family Zn_clus PF00172.18 AAS53452.1 - 2.6e-07 30.6 10.8 5e-07 29.7 10.8 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain PAS PF00989.25 AAS53452.1 - 0.00023 21.1 0.0 0.00048 20.1 0.0 1.5 1 0 0 1 1 1 1 PAS fold PAS_9 PF13426.7 AAS53452.1 - 0.074 13.3 0.3 0.29 11.4 0.1 2.1 2 1 0 2 2 2 0 PAS domain DEAD PF00270.29 AAS53453.1 - 3.4e-39 134.4 0.0 5e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53453.1 - 2.8e-18 66.3 0.0 6e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AAS53453.1 - 1.1e-17 64.0 0.0 2.3e-17 63.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AAS53453.1 - 0.00018 21.5 0.0 0.00032 20.8 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Sin_N PF04801.13 AAS53454.1 - 2.7e-21 76.3 0.7 6.6e-21 75.0 0.7 1.5 1 1 0 1 1 1 1 Sin-like protein conserved region IF-2B PF01008.17 AAS53455.2 - 8.7e-71 238.4 0.0 1e-70 238.1 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family GTP_EFTU PF00009.27 AAS53456.1 - 2.8e-61 206.5 0.0 4.9e-61 205.7 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_II PF14492.6 AAS53456.1 - 1.6e-26 92.1 0.0 3.2e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AAS53456.1 - 2.5e-16 59.5 0.0 2.6e-08 33.8 0.0 2.5 2 0 0 2 2 2 2 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AAS53456.1 - 1.2e-10 41.6 0.9 4.8e-10 39.7 0.2 2.5 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 AAS53456.1 - 6e-09 35.8 0.0 1.2e-08 34.9 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 AAS53456.1 - 0.028 14.5 0.0 0.078 13.1 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase GCS PF03074.16 AAS53457.1 - 3.8e-144 480.6 0.0 4.9e-144 480.2 0.0 1.1 1 0 0 1 1 1 1 Glutamate-cysteine ligase GCS2 PF04107.13 AAS53457.1 - 0.0058 16.0 0.1 0.011 15.1 0.1 1.4 1 0 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) YqbF PF14553.6 AAS53457.1 - 0.082 12.8 1.0 0.18 11.7 0.1 2.1 2 0 0 2 2 2 0 YqbF, hypothetical protein domain PI3_PI4_kinase PF00454.27 AAS53458.2 - 1.8e-52 178.6 0.0 2.6e-52 178.1 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase ChAPs PF09295.10 AAS53459.1 - 3.2e-49 168.0 0.0 1.1e-39 136.6 0.0 2.2 2 0 0 2 2 2 2 ChAPs (Chs5p-Arf1p-binding proteins) TPR_2 PF07719.17 AAS53459.1 - 5.2e-05 23.1 1.3 0.27 11.4 0.1 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS53459.1 - 0.00016 21.6 0.6 1.7 9.0 0.1 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS53459.1 - 0.0016 18.9 5.4 0.0022 18.5 0.2 3.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 AAS53459.1 - 0.0031 17.8 0.3 0.057 13.8 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS53459.1 - 0.0043 16.8 1.4 0.22 11.4 0.1 3.5 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS53459.1 - 0.0099 16.1 0.2 0.046 13.9 0.1 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AAS53459.1 - 0.056 13.7 0.9 0.37 11.1 0.2 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS53459.1 - 0.078 13.0 0.6 28 5.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SAPS PF04499.15 AAS53460.2 - 3.3e-183 610.0 0.0 3.3e-183 610.0 0.0 3.0 3 1 0 3 3 3 1 SIT4 phosphatase-associated protein DUF903 PF06004.12 AAS53460.2 - 0.2 11.6 2.4 8.4 6.4 0.2 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF903) PTPLA PF04387.14 AAS53461.1 - 1.7e-49 167.7 9.6 2.6e-49 167.1 9.6 1.3 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Ribosomal_L21p PF00829.21 AAS53462.1 - 9.3e-12 45.1 0.0 1.1e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein Pkinase PF00069.25 AAS53463.1 - 3.3e-65 220.1 0.0 5.3e-65 219.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53463.1 - 2.9e-44 151.3 0.0 5.1e-44 150.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53463.1 - 8.6e-10 38.4 0.0 6.5e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Kinase-like SAM_2 PF07647.17 AAS53463.1 - 0.016 15.3 0.2 0.035 14.2 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 AAS53463.1 - 0.063 13.2 0.7 0.18 11.8 0.7 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain APH PF01636.23 AAS53463.1 - 0.2 11.5 0.0 0.36 10.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family UvrD-helicase PF00580.21 AAS53464.2 - 6.1e-60 203.4 0.0 2.3e-59 201.5 0.0 1.9 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AAS53464.2 - 1.5e-44 152.9 0.0 1.1e-43 150.0 0.0 2.2 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 AAS53464.2 - 6.7e-28 97.9 0.0 2.1e-27 96.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain UvrD_C_2 PF13538.6 AAS53464.2 - 7.2e-09 35.4 0.1 0.00066 19.5 0.0 2.6 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 AAS53464.2 - 5.2e-05 23.0 0.0 0.01 15.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_12 PF13087.6 AAS53464.2 - 0.00056 19.6 0.0 0.016 14.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 AAS53464.2 - 0.0064 16.2 0.5 40 3.8 0.0 4.2 4 0 0 4 4 4 0 Viral (Superfamily 1) RNA helicase GWT1 PF06423.12 AAS53465.1 - 1.4e-40 138.8 3.8 4.6e-40 137.2 3.8 1.9 1 0 0 1 1 1 1 GWT1 TrbE PF11100.8 AAS53465.1 - 0.029 14.6 0.1 0.16 12.2 0.1 2.3 1 0 0 1 1 1 0 Conjugal transfer protein TrbE PTCB-BRCT PF12738.7 AAS53466.2 - 1.2e-11 44.3 0.2 3.9e-05 23.5 0.0 4.2 4 0 0 4 4 4 2 twin BRCT domain BRCT PF00533.26 AAS53466.2 - 7.2e-11 42.3 0.0 0.009 16.4 0.0 3.5 3 0 0 3 3 3 3 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 AAS53466.2 - 2.3e-09 37.6 0.0 5.1e-06 26.8 0.0 3.3 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT_3 PF18428.1 AAS53466.2 - 0.0012 18.8 0.0 0.0039 17.2 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 AAS53466.2 - 0.12 12.7 0.1 0.62 10.4 0.0 2.2 2 0 0 2 2 2 0 DNA ligase 3 BRCT domain Zn_clus PF00172.18 AAS53467.2 - 6.9e-10 38.9 11.8 1e-09 38.3 11.8 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain NTR2 PF15458.6 AAS53468.1 - 6.9e-09 35.7 2.4 8.6e-09 35.4 2.4 1.3 1 0 0 1 1 1 1 Nineteen complex-related protein 2 bZIP_Maf PF03131.17 AAS53468.1 - 0.02 15.4 1.1 0.58 10.7 0.1 2.5 2 0 0 2 2 2 0 bZIP Maf transcription factor OTCace PF00185.24 AAS53469.1 - 1.3e-48 165.1 0.8 2.1e-48 164.4 0.8 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N PF02729.21 AAS53469.1 - 1.7e-43 148.2 0.9 1.3e-42 145.3 0.1 2.0 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain RNA_lig_T4_1 PF09511.10 AAS53470.2 - 3.1e-77 259.4 0.0 9.2e-77 257.8 0.0 1.9 2 0 0 2 2 2 1 RNA ligase tRNA_lig_kinase PF08303.11 AAS53470.2 - 6.1e-74 247.7 0.7 1.1e-73 246.8 0.7 1.5 1 0 0 1 1 1 1 tRNA ligase kinase domain tRNA_lig_CPD PF08302.11 AAS53470.2 - 2.3e-53 181.2 0.0 5.8e-53 179.9 0.0 1.7 1 1 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain CPT PF07931.12 AAS53470.2 - 0.039 13.8 0.0 0.1 12.5 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein PRK PF00485.18 AAS53470.2 - 0.045 13.5 0.3 0.17 11.6 0.0 2.0 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 AAS53470.2 - 0.1 13.2 0.2 0.54 10.8 0.2 2.3 2 1 0 2 2 2 0 AAA domain Exo70 PF03081.15 AAS53471.1 - 3.2e-83 279.9 3.4 3.2e-83 279.9 3.4 2.2 2 0 0 2 2 2 1 Exo70 exocyst complex subunit DUF573 PF04504.14 AAS53471.1 - 0.13 13.0 1.0 0.36 11.5 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function, DUF573 DUF2385 PF09539.10 AAS53471.1 - 0.15 12.6 0.0 0.5 10.9 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2385) DUF5344 PF17279.2 AAS53471.1 - 1.1 9.9 4.5 2.5 8.8 0.0 3.6 4 1 1 5 5 5 0 Family of unknown function (DUF5344) Arrestin_C PF02752.22 AAS53472.2 - 6.7e-13 49.2 0.1 1.7e-11 44.7 0.0 2.6 2 0 0 2 2 2 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AAS53472.2 - 0.00012 22.2 0.0 0.01 15.9 0.0 2.8 3 0 0 3 3 3 1 Arrestin (or S-antigen), N-terminal domain DLIC PF05783.11 AAS53472.2 - 0.18 10.6 1.0 0.35 9.6 1.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Vps51 PF08700.11 AAS53473.1 - 6.3e-15 55.0 0.1 6.3e-15 55.0 0.1 2.0 2 0 0 2 2 2 1 Vps51/Vps67 LRRFIP PF09738.9 AAS53473.1 - 0.0012 18.4 5.4 0.007 15.9 0.2 2.0 1 1 1 2 2 2 2 LRRFIP family EF-hand_4 PF12763.7 AAS53474.1 - 8e-05 22.5 0.1 8e-05 22.5 0.1 2.1 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand AP2 PF00847.20 AAS53474.1 - 0.034 14.4 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 AP2 domain Sigma70_ner PF04546.13 AAS53474.1 - 0.79 9.6 8.4 0.83 9.5 4.6 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region IBR PF01485.21 AAS53475.1 - 1.4e-15 57.2 26.5 2.1e-09 37.5 6.2 3.9 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 AAS53475.1 - 1.4 8.8 48.7 0.026 14.4 13.6 4.7 3 1 1 4 4 4 0 Zinc finger, C3HC4 type (RING finger) Actin PF00022.19 AAS53476.1 - 1.4e-97 326.9 0.0 8.4e-97 324.3 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 AAS53476.1 - 0.096 11.5 0.0 1.5 7.5 0.0 2.1 2 0 0 2 2 2 0 MreB/Mbl protein Mitofilin PF09731.9 AAS53477.2 - 5.7e-37 127.9 18.9 4.8e-30 105.0 18.9 2.1 1 1 1 2 2 2 2 Mitochondrial inner membrane protein SF-assemblin PF06705.11 AAS53477.2 - 0.24 10.7 10.6 0.78 9.0 4.6 2.5 1 1 1 2 2 2 0 SF-assemblin/beta giardin RRM_1 PF00076.22 AAS53478.1 - 1.2e-40 137.1 1.5 4e-19 68.2 0.0 2.7 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 AAS53478.1 - 0.00018 21.1 0.0 0.038 13.6 0.0 2.5 1 1 1 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS53478.1 - 0.014 15.5 0.1 6.9 6.9 0.0 2.7 2 1 0 2 2 2 0 RNA recognition motif DbpA PF03880.15 AAS53478.1 - 0.1 12.6 0.0 18 5.4 0.0 2.3 2 0 0 2 2 2 0 DbpA RNA binding domain Prothymosin PF03247.14 AAS53478.1 - 2.1 8.8 41.2 1.2 9.6 22.3 2.3 1 1 1 2 2 2 0 Prothymosin/parathymosin family Arrestin_N PF00339.29 AAS53479.1 - 1.4e-20 73.8 0.0 1.7e-19 70.3 0.0 2.2 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Arrestin_C PF02752.22 AAS53479.1 - 1.2e-10 41.9 0.1 2.7e-10 40.8 0.1 1.5 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain RNase_PH PF01138.21 AAS53480.1 - 1.2e-17 64.7 0.0 1.7e-17 64.1 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 TSKS PF15358.6 AAS53480.1 - 0.23 9.8 0.0 0.28 9.5 0.0 1.1 1 0 0 1 1 1 0 Testis-specific serine kinase substrate PEMT PF04191.13 AAS53481.1 - 1.5e-53 179.6 15.5 7.6e-30 103.4 1.5 3.5 3 1 1 4 4 4 2 Phospholipid methyltransferase SKICH PF17751.1 AAS53481.1 - 0.0043 17.6 0.2 0.046 14.3 0.2 2.5 1 1 0 1 1 1 1 SKICH domain HECW_N PF16562.5 AAS53481.1 - 0.0085 15.9 0.1 0.019 14.7 0.1 1.6 1 0 0 1 1 1 1 N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2 ICMT PF04140.14 AAS53481.1 - 0.033 14.6 5.7 1.7 9.1 0.4 3.7 2 1 1 3 3 3 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Septin PF00735.18 AAS53482.2 - 4.5e-112 373.9 0.5 4.5e-112 373.9 0.5 1.7 2 0 0 2 2 2 1 Septin MMR_HSR1 PF01926.23 AAS53482.2 - 2.9e-05 24.1 0.4 2.9e-05 24.1 0.4 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS53482.2 - 0.0015 19.0 0.3 0.0089 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 AAS53482.2 - 0.0048 16.9 1.0 0.011 15.7 0.0 2.2 2 1 0 2 2 2 1 AAA domain Lipocalin PF00061.23 AAS53482.2 - 0.011 15.9 0.5 0.038 14.2 0.5 1.9 1 0 0 1 1 1 0 Lipocalin / cytosolic fatty-acid binding protein family AAA_22 PF13401.6 AAS53482.2 - 0.015 15.6 1.3 0.061 13.6 0.0 2.6 3 1 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 AAS53482.2 - 0.016 14.8 4.8 0.059 12.9 0.1 2.9 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 AAS53482.2 - 0.025 15.1 2.6 0.64 10.5 0.0 2.8 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 AAS53482.2 - 0.026 14.4 0.7 0.026 14.4 0.7 2.9 3 1 0 3 3 3 0 RsgA GTPase Exonuc_VII_L PF02601.15 AAS53482.2 - 0.033 13.8 12.7 0.05 13.2 12.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FtsK_SpoIIIE PF01580.18 AAS53482.2 - 0.075 12.4 0.5 0.19 11.0 0.0 1.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 AAS53482.2 - 0.2 11.7 0.1 0.2 11.7 0.1 3.4 2 2 1 3 3 3 0 Dynamin family AAA_23 PF13476.6 AAS53482.2 - 0.56 10.7 16.4 4.3 7.8 10.8 2.3 2 0 0 2 2 2 0 AAA domain Strep_SA_rep PF06696.11 AAS53482.2 - 0.79 9.8 8.6 0.15 12.1 1.6 2.4 2 0 0 2 2 2 0 Streptococcal surface antigen repeat FapA PF03961.13 AAS53482.2 - 1.8 7.1 13.9 3.3 6.2 13.9 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A AIG1 PF04548.16 AAS53482.2 - 1.8 7.8 8.3 0.52 9.6 0.9 2.8 2 1 0 2 2 2 0 AIG1 family HSP70 PF00012.20 AAS53482.2 - 6.3 4.8 10.0 11 4.1 10.0 1.3 1 0 0 1 1 1 0 Hsp70 protein DUF2852 PF11014.8 AAS53482.2 - 6.8 6.9 7.8 0.69 10.1 1.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) SHNi-TPR PF10516.9 AAS53483.2 - 2.2e-16 59.0 5.0 7.9e-16 57.2 0.5 3.1 2 0 0 2 2 2 1 SHNi-TPR TPR_12 PF13424.6 AAS53483.2 - 0.009 16.3 1.8 0.009 16.3 1.8 3.5 4 2 1 5 5 5 1 Tetratricopeptide repeat DnaG_DnaB_bind PF08278.11 AAS53483.2 - 0.077 13.6 0.1 0.077 13.6 0.1 2.4 2 1 1 3 3 3 0 DNA primase DnaG DnaB-binding TPR_10 PF13374.6 AAS53483.2 - 0.35 10.8 0.1 0.35 10.8 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 AAS53483.2 - 2.9 7.2 10.0 12 5.2 10.0 1.9 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 AAS53483.2 - 4.4 7.7 16.9 2.5 8.4 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat UPF0121 PF03661.13 AAS53484.1 - 7.8e-26 90.9 2.3 1.1e-25 90.5 2.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) HSP70 PF00012.20 AAS53485.1 - 2.8e-263 874.6 7.2 3.2e-263 874.4 7.2 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS53485.1 - 4.5e-18 65.2 0.0 8.5e-17 60.9 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 AAS53485.1 - 0.0011 18.7 0.0 0.0032 17.2 0.0 1.8 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain Hydantoinase_A PF01968.18 AAS53485.1 - 0.022 14.0 0.1 0.022 14.0 0.1 2.3 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase ExsD PF16806.5 AAS53485.1 - 0.073 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 Antiactivator protein ExsD FtsA PF14450.6 AAS53485.1 - 0.085 13.3 3.0 15 6.1 0.0 3.6 3 2 0 3 3 3 0 Cell division protein FtsA GAF_2 PF13185.6 AAS53486.1 - 1.6e-12 47.9 0.0 2.3e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 AAS53486.1 - 5.2e-07 30.4 0.0 6.9e-07 30.0 0.0 1.3 1 1 0 1 1 1 1 GAF domain GAF_3 PF13492.6 AAS53486.1 - 0.059 13.7 0.0 0.11 12.9 0.0 1.5 1 1 0 1 1 1 0 GAF domain Ferric_reduct PF01794.19 AAS53487.1 - 3.3e-19 69.2 13.0 3.3e-19 69.2 13.0 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 AAS53487.1 - 1.9e-12 47.2 0.0 4.2e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 FAD-binding domain NAD_binding_6 PF08030.12 AAS53487.1 - 5.1e-06 26.7 0.0 4e-05 23.8 0.0 2.0 1 1 0 1 1 1 1 Ferric reductase NAD binding domain Fungal_trans PF04082.18 AAS53488.2 - 5.8e-08 32.1 3.0 3.3e-07 29.6 3.0 2.1 1 1 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS53488.2 - 6.2e-08 32.6 9.1 1.2e-07 31.7 9.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Borrelia_REV PF03978.13 AAS53488.2 - 0.027 14.4 1.5 19 5.2 0.3 3.2 3 0 0 3 3 3 0 Borrelia burgdorferi REV protein SHE3 PF17078.5 AAS53489.1 - 0.018 14.7 5.8 0.023 14.4 5.8 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 NTase_sub_bind PF08780.11 AAS53489.1 - 0.028 14.4 3.0 0.043 13.8 3.0 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase substrate binding protein like CC2-LZ PF16516.5 AAS53489.1 - 0.03 14.7 8.0 0.03 14.7 8.0 1.7 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PIN_8 PF18476.1 AAS53489.1 - 0.041 13.7 1.6 0.054 13.3 1.6 1.1 1 0 0 1 1 1 0 PIN like domain DUF2937 PF11157.8 AAS53489.1 - 0.086 12.6 3.1 0.14 11.9 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) Ycf1 PF05758.12 AAS53489.1 - 0.19 9.5 1.7 0.24 9.2 1.7 1.0 1 0 0 1 1 1 0 Ycf1 HalX PF08663.10 AAS53489.1 - 0.23 11.8 6.2 0.5 10.7 6.1 1.6 1 1 0 1 1 1 0 HalX domain DUF724 PF05266.14 AAS53489.1 - 0.43 10.4 8.8 0.57 10.0 8.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) ACCA PF03255.14 AAS53489.1 - 0.7 9.8 3.8 1.1 9.1 3.4 1.5 1 1 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Baculo_PEP_C PF04513.12 AAS53489.1 - 0.91 9.6 7.2 0.29 11.2 4.4 1.6 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FlxA PF14282.6 AAS53489.1 - 2.1 8.4 18.8 4.4 7.4 1.0 2.5 1 1 1 2 2 2 0 FlxA-like protein HMMR_N PF15905.5 AAS53489.1 - 2.7 7.4 13.5 3.9 6.9 13.5 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Tup_N PF08581.10 AAS53489.1 - 2.9 8.3 14.5 0.56 10.5 3.2 2.5 2 1 1 3 3 3 0 Tup N-terminal Spc7 PF08317.11 AAS53489.1 - 3.2 6.5 12.9 4.1 6.2 12.9 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein PRKG1_interact PF15898.5 AAS53489.1 - 3.3 8.7 9.0 4.6 8.2 8.2 1.6 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ABC1 PF03109.16 AAS53490.2 - 3.9e-32 110.9 0.2 9.5e-32 109.7 0.0 1.7 2 0 0 2 2 2 1 ABC1 family RIO1 PF01163.22 AAS53490.2 - 0.0075 15.9 0.0 0.055 13.1 0.0 2.2 2 0 0 2 2 2 1 RIO1 family Mpv17_PMP22 PF04117.12 AAS53491.1 - 1.6e-25 89.1 2.7 3.1e-25 88.2 2.7 1.5 1 0 0 1 1 1 1 Mpv17 / PMP22 family CENP-H PF05837.12 AAS53492.2 - 0.018 15.4 1.1 1.2 9.6 0.2 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) TP_methylase PF00590.20 AAS53494.1 - 3.7e-26 92.4 0.0 5.1e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Clat_adaptor_s PF01217.20 AAS53495.1 - 3.3e-54 182.7 1.4 3.8e-54 182.5 1.4 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF4808 PF16066.5 AAS53495.1 - 0.097 13.2 0.0 0.19 12.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) Mem_trans PF03547.18 AAS53497.1 - 4.8e-58 196.4 8.5 1.1e-57 195.3 8.5 1.5 1 1 0 1 1 1 1 Membrane transport protein Erv26 PF04148.13 AAS53498.2 - 8.6e-80 267.4 3.3 1e-79 267.2 3.3 1.0 1 0 0 1 1 1 1 Transmembrane adaptor Erv26 7TM_GPCR_Srh PF10318.9 AAS53498.2 - 0.00089 18.4 5.8 0.00089 18.4 5.8 1.5 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srh COX1 PF00115.20 AAS53498.2 - 0.041 12.7 3.0 0.049 12.5 3.0 1.1 1 0 0 1 1 1 0 Cytochrome C and Quinol oxidase polypeptide I DUF996 PF06195.13 AAS53498.2 - 0.63 10.3 4.8 0.16 12.2 1.5 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF996) 6PGD PF00393.19 AAS53500.2 - 4.3e-125 416.9 0.0 5.6e-125 416.5 0.0 1.1 1 0 0 1 1 1 1 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 AAS53500.2 - 1.1e-51 175.2 0.0 1.6e-51 174.6 0.0 1.2 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AAS53500.2 - 0.0014 19.1 0.1 0.0026 18.3 0.1 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 AAS53500.2 - 0.03 13.7 0.0 0.055 12.8 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_11 PF14833.6 AAS53500.2 - 0.069 13.4 0.1 0.27 11.5 0.0 2.0 2 0 0 2 2 2 0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase DUF4749 PF15936.5 AAS53501.1 - 0.051 14.7 1.0 0.17 13.1 1.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4749) Mito_carr PF00153.27 AAS53502.2 - 1.3e-59 198.1 0.2 8.3e-23 80.1 0.1 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein PsaL PF02605.15 AAS53502.2 - 0.018 14.7 1.1 0.034 13.8 0.4 1.8 2 0 0 2 2 2 0 Photosystem I reaction centre subunit XI XPG_N PF00752.17 AAS53504.1 - 4e-35 120.3 0.0 9.4e-35 119.1 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 AAS53504.1 - 2.4e-25 88.7 0.0 6.6e-25 87.3 0.0 1.8 1 0 0 1 1 1 1 XPG I-region 5_3_exonuc PF01367.20 AAS53504.1 - 0.0014 19.2 0.0 0.0048 17.5 0.0 1.9 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold XPG_I_2 PF12813.7 AAS53504.1 - 0.0059 16.1 0.0 0.019 14.5 0.0 1.9 1 1 0 1 1 1 1 XPG domain containing PDEase_I PF00233.19 AAS53504.1 - 0.085 12.6 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Glu-tRNAGln PF02686.15 AAS53504.1 - 1.2 9.5 3.5 60 4.0 0.0 3.2 2 1 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit Ligase_CoA PF00549.19 AAS53505.2 - 3.8e-24 85.2 1.1 6.5e-24 84.5 1.1 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 AAS53505.2 - 2.7e-23 82.4 3.6 2.9e-23 82.3 1.4 2.0 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 AAS53505.2 - 1.1e-09 38.2 0.2 1.8e-09 37.5 0.2 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AAS53505.2 - 4.8e-06 27.1 0.4 1.3e-05 25.7 0.1 1.8 2 0 0 2 2 2 1 CoA binding domain Actin PF00022.19 AAS53506.1 - 3.9e-21 75.1 0.0 1e-15 57.3 0.0 3.4 3 1 0 3 3 3 2 Actin Actin_micro PF17003.5 AAS53506.1 - 1.5e-10 40.8 2.2 0.00022 20.5 0.3 2.5 2 0 0 2 2 2 2 Putative actin-like family MreB_Mbl PF06723.13 AAS53506.1 - 5.6e-06 25.4 0.0 9.6e-05 21.3 0.0 2.3 2 0 0 2 2 2 1 MreB/Mbl protein FtsA PF14450.6 AAS53506.1 - 0.0053 17.2 0.2 0.017 15.6 0.2 2.1 1 1 0 1 1 1 1 Cell division protein FtsA DUF1002 PF06207.11 AAS53506.1 - 0.074 12.6 1.2 0.15 11.6 1.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) HSA PF07529.13 AAS53506.1 - 5.3 7.4 9.4 9.7 6.6 0.8 2.4 2 0 0 2 2 2 0 HSA HSF_DNA-bind PF00447.17 AAS53507.1 - 2.5e-30 104.9 2.5 4.8e-30 104.0 2.5 1.5 1 0 0 1 1 1 1 HSF-type DNA-binding Iso_dh PF00180.20 AAS53508.1 - 1.7e-101 339.9 0.0 2.1e-101 339.5 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase ThiF PF00899.21 AAS53509.1 - 1.5e-65 220.9 0.0 2.4e-65 220.3 0.0 1.3 1 0 0 1 1 1 1 ThiF family UBA_e1_thiolCys PF10585.9 AAS53509.1 - 5.3e-08 33.1 0.1 0.00012 22.2 0.0 2.4 1 1 1 2 2 2 2 Ubiquitin-activating enzyme active site NAD_binding_7 PF13241.6 AAS53509.1 - 0.00011 22.6 0.3 0.00031 21.1 0.0 1.9 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 AAS53509.1 - 0.00081 19.5 0.1 0.0018 18.3 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UAE_UbL PF14732.6 AAS53509.1 - 0.001 19.6 0.1 0.0023 18.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Pyr_redox PF00070.27 AAS53509.1 - 0.031 14.9 0.6 0.11 13.0 0.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RhoGAP PF00620.27 AAS53510.2 - 1.4e-30 106.1 0.1 6.1e-30 104.1 0.1 2.0 1 1 0 1 1 1 1 RhoGAP domain TFIIA PF03153.13 AAS53510.2 - 0.34 10.9 33.5 0.036 14.1 26.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit BAR PF03114.18 AAS53511.2 - 5.2e-60 203.1 1.8 6.3e-60 202.8 1.8 1.1 1 0 0 1 1 1 1 BAR domain SH3_1 PF00018.28 AAS53511.2 - 4.9e-16 58.1 0.0 7.9e-16 57.4 0.0 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS53511.2 - 1.4e-12 47.3 0.0 2.8e-12 46.3 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS53511.2 - 3.4e-07 29.8 0.0 7.1e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain ERCC4 PF02732.15 AAS53512.1 - 4.4e-22 79.0 0.0 8.7e-22 78.0 0.0 1.5 1 0 0 1 1 1 1 ERCC4 domain HHH_8 PF14716.6 AAS53512.1 - 0.00015 22.1 0.0 0.00033 21.0 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain Exotox-A_target PF09102.10 AAS53512.1 - 0.07 13.1 0.0 0.22 11.5 0.0 1.9 1 0 0 1 1 1 0 Exotoxin A, targeting GTP_EFTU PF00009.27 AAS53513.1 - 4.5e-68 228.6 0.2 6.4e-68 228.1 0.2 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AAS53513.1 - 1.5e-32 111.9 0.0 5.9e-32 110.0 0.0 2.0 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_C PF00679.24 AAS53513.1 - 8.4e-22 77.0 0.0 2.4e-21 75.6 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 AAS53513.1 - 2.2e-13 50.1 0.0 7.4e-13 48.4 0.0 1.9 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 AAS53513.1 - 1.6e-12 47.6 0.0 5.1e-12 46.0 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS53513.1 - 9.7e-05 22.4 0.3 0.00019 21.5 0.3 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase PX PF00787.24 AAS53514.2 - 6.1e-11 42.3 0.0 1.3e-10 41.3 0.0 1.5 1 0 0 1 1 1 1 PX domain Vps5 PF09325.10 AAS53514.2 - 3.4e-06 26.8 6.8 5.7e-06 26.0 6.8 1.3 1 0 0 1 1 1 1 Vps5 C terminal like Rhabdo_ncap PF00945.18 AAS53514.2 - 0.12 11.2 0.0 0.2 10.5 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Gpr1_Fun34_YaaH PF01184.19 AAS53515.1 - 2.4e-68 229.8 15.1 3e-68 229.5 15.1 1.0 1 0 0 1 1 1 1 GPR1/FUN34/yaaH family Ribosomal_60s PF00428.19 AAS53516.1 - 1.6e-26 92.7 14.1 1.8e-26 92.5 14.1 1.0 1 0 0 1 1 1 1 60s Acidic ribosomal protein Mito_carr PF00153.27 AAS53517.1 - 3e-55 184.1 2.6 2.5e-18 65.8 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 AAS53517.1 - 0.34 11.3 5.3 1.3 9.5 0.3 3.0 2 1 0 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family Mito_carr PF00153.27 AAS53518.2 - 3.8e-46 154.9 5.1 6.2e-15 54.9 0.1 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein HMD PF03201.16 AAS53518.2 - 0.039 14.2 0.1 5.3 7.3 0.1 3.0 3 0 0 3 3 3 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase RRM_1 PF00076.22 AAS53520.1 - 2.4e-12 46.5 0.0 4.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication PF13865.6 AAS53520.1 - 0.043 14.4 0.8 0.043 14.4 0.8 2.8 2 1 1 3 3 3 0 C-terminal duplication domain of Friend of PRMT1 Pkinase PF00069.25 AAS53521.1 - 5.6e-33 114.4 0.0 1.6e-32 112.9 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53521.1 - 2.8e-26 92.4 0.0 4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AAS53521.1 - 1.7e-07 31.4 1.9 1.5e-05 25.1 0.2 2.5 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AAS53521.1 - 3.7e-05 23.2 0.0 5.9e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AAS53521.1 - 0.0014 18.1 0.0 0.0034 16.7 0.0 1.6 2 0 0 2 2 2 1 Kinase-like RIO1 PF01163.22 AAS53521.1 - 0.011 15.3 0.0 0.028 14.0 0.0 1.7 2 0 0 2 2 2 0 RIO1 family Haspin_kinase PF12330.8 AAS53521.1 - 0.018 14.0 0.0 0.028 13.4 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Choline_kinase PF01633.20 AAS53521.1 - 0.049 13.2 0.0 0.4 10.2 0.0 2.0 1 1 1 2 2 2 0 Choline/ethanolamine kinase FA_hydroxylase PF04116.13 AAS53522.2 - 3.7e-23 82.3 17.2 3.7e-23 82.3 17.2 2.3 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily ABC_tran PF00005.27 AAS53523.1 - 6e-18 65.7 0.0 2.4e-17 63.7 0.0 1.9 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AAS53523.1 - 1.8e-08 34.5 2.1 0.0023 17.8 0.6 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS53523.1 - 0.00018 21.1 0.0 0.074 12.5 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain RsgA_GTPase PF03193.16 AAS53523.1 - 0.00056 19.9 0.0 0.0008 19.3 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 AAS53523.1 - 0.0036 17.0 0.1 0.0067 16.1 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_18 PF13238.6 AAS53523.1 - 0.0041 17.7 0.0 0.0081 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 AAS53523.1 - 0.012 14.9 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Rad17 PF03215.15 AAS53523.1 - 0.038 13.9 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 AAS53523.1 - 0.04 14.4 0.0 0.059 13.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 AAS53523.1 - 0.051 13.3 0.0 0.077 12.7 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 AAS53523.1 - 0.092 12.8 0.0 0.17 12.0 0.0 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 AAS53523.1 - 0.097 12.9 1.2 0.34 11.2 1.2 2.0 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AAS53523.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 AAS53523.1 - 0.11 12.5 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Dynamin family DUF3584 PF12128.8 AAS53523.1 - 0.22 9.0 0.0 0.29 8.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) WD40 PF00400.32 AAS53524.2 - 0.00011 22.8 11.2 2.4 9.1 0.1 6.8 8 0 0 8 8 8 2 WD domain, G-beta repeat COPI_C PF06957.11 AAS53524.2 - 0.13 11.0 6.7 0.21 10.3 6.7 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus RabGAP-TBC PF00566.18 AAS53525.1 - 4.8e-12 46.0 7.3 1e-11 44.9 7.3 1.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Cpn60_TCP1 PF00118.24 AAS53526.2 - 8.7e-83 278.6 10.7 5.7e-82 275.9 10.7 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family AA_permease PF00324.21 AAS53527.2 - 5.6e-122 407.8 34.6 6.9e-122 407.5 34.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS53527.2 - 1.2e-29 103.5 36.0 1.6e-29 103.0 36.0 1.1 1 0 0 1 1 1 1 Amino acid permease NCE101 PF11654.8 AAS53527.2 - 0.0082 15.8 0.1 0.033 13.9 0.1 2.1 1 0 0 1 1 1 1 Non-classical export protein 1 HIT PF01230.23 AAS53528.1 - 9.8e-25 87.2 0.0 1.5e-24 86.6 0.0 1.3 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AAS53528.1 - 6.6e-10 39.5 0.0 1.1e-09 38.7 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 AAS53528.1 - 0.056 13.3 0.9 0.12 12.2 0.9 1.7 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 AAA PF00004.29 AAS53529.2 - 2.6e-98 325.6 0.0 2.8e-48 163.7 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS53529.2 - 5.5e-25 86.9 6.5 3.8e-13 49.0 0.5 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AAS53529.2 - 3.9e-17 62.2 0.8 9.9e-17 60.9 0.3 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 AAS53529.2 - 8.2e-14 51.6 0.0 1.3e-05 25.0 0.0 2.9 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AAS53529.2 - 1.7e-13 51.3 0.3 0.00012 22.5 0.0 5.1 3 2 0 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 AAS53529.2 - 2.1e-13 50.8 0.0 5.6e-07 29.8 0.0 2.8 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 AAS53529.2 - 2.2e-11 44.1 0.0 1.1e-05 25.6 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AAS53529.2 - 2.6e-11 43.7 1.4 9.9e-06 25.6 0.1 3.9 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 AAS53529.2 - 7.9e-10 38.4 0.1 4.5e-09 36.0 0.0 2.3 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 TIP49 PF06068.13 AAS53529.2 - 2.5e-09 36.8 0.0 0.0018 17.6 0.0 2.6 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AAS53529.2 - 1e-08 35.5 0.9 0.071 13.4 0.0 4.0 2 2 2 4 4 4 2 AAA domain AAA_14 PF13173.6 AAS53529.2 - 1.5e-07 31.5 0.0 0.021 14.9 0.0 3.5 4 0 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 AAS53529.2 - 2.7e-07 30.9 0.0 0.012 16.0 0.0 3.0 3 0 0 3 3 2 2 RNA helicase Vps4_C PF09336.10 AAS53529.2 - 3.1e-07 30.3 2.4 1.4e-05 25.0 0.2 2.9 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 AAS53529.2 - 4e-07 29.6 0.4 0.032 13.6 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 AAS53529.2 - 7.1e-07 29.1 0.0 0.03 14.1 0.0 2.9 2 0 0 2 2 2 2 IstB-like ATP binding protein ATPase PF06745.13 AAS53529.2 - 2.8e-06 26.9 1.2 0.33 10.3 0.0 3.6 2 1 0 3 3 3 2 KaiC AAA_7 PF12775.7 AAS53529.2 - 4.7e-06 26.2 0.1 0.058 12.9 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AAS53529.2 - 5.5e-06 26.2 0.0 0.078 12.7 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AAS53529.2 - 6.6e-06 26.7 0.0 0.22 12.1 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 AAS53529.2 - 7.3e-06 25.7 4.0 0.039 13.5 0.2 4.1 2 2 1 3 3 3 1 AAA domain Sigma54_activat PF00158.26 AAS53529.2 - 1.5e-05 24.7 0.1 0.17 11.5 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain ABC_tran PF00005.27 AAS53529.2 - 2.1e-05 25.1 0.0 0.027 15.0 0.0 3.4 2 1 0 2 2 2 1 ABC transporter PhoH PF02562.16 AAS53529.2 - 2.8e-05 23.7 0.2 0.16 11.4 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_28 PF13521.6 AAS53529.2 - 3.3e-05 24.2 0.2 0.57 10.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain Parvo_NS1 PF01057.17 AAS53529.2 - 3.9e-05 22.9 0.1 0.13 11.3 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Bac_DnaA PF00308.18 AAS53529.2 - 4.8e-05 23.3 0.0 0.073 12.9 0.0 2.7 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_11 PF13086.6 AAS53529.2 - 9.2e-05 22.4 0.3 0.73 9.6 0.0 2.9 3 0 0 3 3 3 2 AAA domain AAA_17 PF13207.6 AAS53529.2 - 0.00012 22.6 0.0 0.57 10.6 0.0 3.2 2 0 0 2 2 2 2 AAA domain AAA_3 PF07726.11 AAS53529.2 - 0.00017 21.4 0.0 0.79 9.6 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 AAS53529.2 - 0.00018 20.7 0.0 0.22 10.7 0.0 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF815) TsaE PF02367.17 AAS53529.2 - 0.00029 20.8 0.0 0.7 9.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ResIII PF04851.15 AAS53529.2 - 0.00042 20.4 0.0 0.093 12.7 0.0 2.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 AAS53529.2 - 0.00067 19.0 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 AAS53529.2 - 0.0012 18.8 0.2 2.6 7.9 0.1 3.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 AAS53529.2 - 0.0017 18.1 0.3 2.4 7.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AAS53529.2 - 0.0019 18.1 0.2 2.2 8.1 0.0 3.2 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 AAS53529.2 - 0.0027 18.0 0.8 3 8.2 0.0 3.1 2 1 1 3 3 2 1 AAA domain Zeta_toxin PF06414.12 AAS53529.2 - 0.0067 15.7 0.1 2 7.6 0.1 2.7 2 0 0 2 2 2 1 Zeta toxin Sigma54_activ_2 PF14532.6 AAS53529.2 - 0.014 15.5 0.0 1.4 9.0 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain IPT PF01745.16 AAS53529.2 - 0.018 14.5 0.1 2.2 7.6 0.0 2.3 2 0 0 2 2 2 0 Isopentenyl transferase NB-ARC PF00931.22 AAS53529.2 - 0.025 13.7 0.1 4.9 6.3 0.0 2.5 2 0 0 2 2 2 0 NB-ARC domain KAP_NTPase PF07693.14 AAS53529.2 - 0.045 13.0 0.2 1.9 7.6 0.0 2.7 2 2 0 2 2 2 0 KAP family P-loop domain Zot PF05707.12 AAS53529.2 - 0.046 13.4 0.0 2.8 7.6 0.0 3.1 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) NTPase_1 PF03266.15 AAS53529.2 - 0.061 13.2 1.2 8.2 6.3 0.0 3.7 4 0 0 4 4 3 0 NTPase AAA_6 PF12774.7 AAS53529.2 - 0.12 11.3 0.4 5.6 5.8 0.0 2.4 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region eIF-1a PF01176.19 AAS53529.2 - 0.2 11.5 0.5 1.4 8.8 0.2 2.5 1 1 1 2 2 2 0 Translation initiation factor 1A / IF-1 Viral_helicase1 PF01443.18 AAS53529.2 - 0.21 11.3 0.0 19 4.9 0.0 2.9 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase Cyclin_N PF00134.23 AAS53530.1 - 1.8e-18 66.5 0.1 2.8e-18 65.9 0.1 1.2 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin PF08613.11 AAS53530.1 - 2e-06 28.3 0.0 3.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Cyclin IL22 PF14565.6 AAS53530.1 - 0.061 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Na_Ca_ex PF01699.24 AAS53531.2 - 9.3e-49 165.3 38.3 1.3e-24 86.9 12.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Ribosomal_60s PF00428.19 AAS53534.1 - 3.5e-24 85.2 14.3 4.1e-24 85.0 14.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein MTTB PF06253.11 AAS53534.1 - 0.077 11.0 0.1 0.077 11.0 0.1 2.0 1 1 1 2 2 2 0 Trimethylamine methyltransferase (MTTB) TraT PF05818.12 AAS53534.1 - 1.8 8.2 4.9 2.3 7.8 4.9 1.1 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein tRNA_bind PF01588.20 AAS53535.1 - 5.4e-20 71.3 0.0 8.6e-20 70.7 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain EMP24_GP25L PF01105.24 AAS53536.1 - 8e-43 146.5 0.0 1e-42 146.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Metallophos PF00149.28 AAS53537.2 - 3.1e-40 138.8 0.0 4.1e-40 138.5 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 AAS53537.2 - 1.6e-22 79.7 2.0 1.9e-22 79.4 0.7 1.8 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Yip1 PF04893.17 AAS53538.1 - 0.011 15.5 16.0 0.018 14.8 16.0 1.6 1 1 0 1 1 1 0 Yip1 domain Kelch_6 PF13964.6 AAS53539.2 - 1.8e-14 53.4 0.3 5.6e-08 32.8 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 AAS53539.2 - 1.9e-08 33.7 6.7 1.6e-05 24.4 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 AAS53539.2 - 5.4e-07 29.5 0.1 1.9e-05 24.5 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 AAS53539.2 - 1.3e-06 28.2 1.8 0.0043 17.0 0.1 3.9 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 AAS53539.2 - 3.7e-05 23.9 0.1 0.1 12.9 0.0 4.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 AAS53539.2 - 4.4e-05 23.4 2.4 0.0023 17.9 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain HEAT_EZ PF13513.6 AAS53540.2 - 2.5e-34 117.2 23.8 0.00013 22.4 0.7 18.7 16 4 4 20 20 20 5 HEAT-like repeat HEAT PF02985.22 AAS53540.2 - 6.6e-29 97.5 20.5 0.0029 17.7 0.0 18.7 23 0 0 23 23 18 5 HEAT repeat Gcn1_N PF12074.8 AAS53540.2 - 1.5e-27 96.9 13.9 8.3e-14 51.6 0.0 5.3 5 1 1 6 6 6 2 Generalcontrol nonderepressible 1 (Gcn1) N-terminal HEAT_2 PF13646.6 AAS53540.2 - 5.2e-26 90.8 21.6 0.0001 22.6 0.8 12.3 8 4 4 12 12 11 5 HEAT repeats Cnd1 PF12717.7 AAS53540.2 - 8e-13 48.7 19.8 0.41 10.7 0.0 11.0 7 2 6 13 13 13 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 AAS53540.2 - 1e-12 48.2 1.4 0.00037 20.1 0.0 7.2 7 1 2 9 9 9 3 CLASP N terminal Vac14_Fab1_bd PF12755.7 AAS53540.2 - 1.4e-11 44.9 3.1 0.078 13.6 0.0 10.1 10 2 2 12 12 12 2 Vacuolar 14 Fab1-binding region DUF3385 PF11865.8 AAS53540.2 - 3.3e-10 40.1 8.5 0.095 12.6 0.0 9.5 7 1 1 8 8 8 2 Domain of unknown function (DUF3385) UME PF08064.13 AAS53540.2 - 4.8e-07 29.6 6.5 0.014 15.2 0.1 8.2 9 2 2 11 11 11 1 UME (NUC010) domain ParcG PF10274.9 AAS53540.2 - 0.0015 18.7 1.7 4.8 7.2 0.0 5.4 5 1 1 6 6 6 1 Parkin co-regulated protein RIX1 PF08167.12 AAS53540.2 - 0.013 15.2 8.7 1.5 8.5 0.0 5.7 6 0 0 6 6 6 0 rRNA processing/ribosome biogenesis Tti2 PF10521.9 AAS53540.2 - 0.015 14.9 1.1 0.28 10.7 0.0 3.9 3 0 0 3 3 3 0 Tti2 family Arm PF00514.23 AAS53540.2 - 0.059 13.4 5.0 3.2 7.9 0.1 6.0 6 0 0 6 6 5 0 Armadillo/beta-catenin-like repeat DUF1400 PF07176.11 AAS53540.2 - 0.39 11.0 2.7 38 4.6 0.0 4.4 4 0 0 4 4 4 0 Alpha/beta hydrolase of unknown function (DUF1400) ADSL_C PF10397.9 AAS53540.2 - 0.74 10.4 2.8 8.7 7.0 0.0 3.9 4 0 0 4 4 3 0 Adenylosuccinate lyase C-terminus UNC45-central PF11701.8 AAS53540.2 - 2.9 7.8 11.0 71 3.3 0.1 6.6 8 1 0 8 8 8 0 Myosin-binding striated muscle assembly central DUF3392 PF11872.8 AAS53541.1 - 0.0057 16.9 0.1 0.0067 16.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3392) Zn_clus PF00172.18 AAS53542.1 - 3.4e-08 33.5 10.6 7.2e-08 32.4 10.6 1.6 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 AAS53542.1 - 1.1e-07 31.0 0.3 1.6e-07 30.5 0.3 1.2 1 0 0 1 1 1 1 Fungal specific transcription factor domain Hist_deacetyl PF00850.19 AAS53543.1 - 1.1e-83 281.2 0.0 1.4e-83 280.9 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain MT-A70 PF05063.14 AAS53544.1 - 9.8e-55 185.1 0.1 1.5e-54 184.5 0.1 1.3 1 0 0 1 1 1 1 MT-A70 Complex1_LYR PF05347.15 AAS53545.1 - 0.0031 17.5 0.2 0.012 15.7 0.2 2.0 1 0 0 1 1 1 1 Complex 1 protein (LYR family) RPAP2_Rtr1 PF04181.13 AAS53546.1 - 7.5e-19 67.8 0.9 1.1e-18 67.2 0.9 1.3 1 0 0 1 1 1 1 Rtr1/RPAP2 family DUF747 PF05346.11 AAS53547.2 - 6.8e-85 285.3 17.1 1.2e-84 284.6 17.1 1.4 1 0 0 1 1 1 1 Eukaryotic membrane protein family zf-UBR PF02207.20 AAS53548.1 - 8.1e-12 45.1 13.2 8.1e-12 45.1 13.2 2.3 2 1 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) MCM PF00493.23 AAS53549.1 - 8.6e-103 342.2 0.0 1.3e-102 341.6 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AAS53549.1 - 6.7e-37 126.2 0.0 1.2e-36 125.3 0.0 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AAS53549.1 - 4.6e-25 87.9 0.1 1.1e-24 86.6 0.1 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM2_N PF12619.8 AAS53549.1 - 1.8e-24 86.8 31.7 1.8e-24 86.8 31.7 3.0 3 0 0 3 3 3 1 Mini-chromosome maintenance protein 2 MCM_N PF14551.6 AAS53549.1 - 6.4e-12 46.0 0.1 1.7e-11 44.6 0.1 1.7 1 0 0 1 1 1 1 MCM N-terminal domain Mg_chelatase PF01078.21 AAS53549.1 - 3e-09 36.6 0.0 3.2e-07 29.9 0.0 2.6 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AAS53549.1 - 1.4e-07 31.6 0.0 3.9e-07 30.1 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AAS53549.1 - 0.00038 20.3 0.0 0.0026 17.6 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AAS53549.1 - 0.0018 18.0 0.1 0.012 15.3 0.1 2.1 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA PF00004.29 AAS53549.1 - 0.017 15.6 0.0 0.055 13.9 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AAS53549.1 - 0.047 13.4 0.1 0.095 12.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain Casc1 PF12366.8 AAS53549.1 - 0.08 12.5 0.0 0.17 11.3 0.0 1.5 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 Yippee-Mis18 PF03226.14 AAS53549.1 - 0.15 12.3 0.1 0.31 11.3 0.1 1.5 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Methyltr_RsmB-F PF01189.17 AAS53550.2 - 2.5e-40 138.3 0.0 1.4e-39 135.8 0.0 2.1 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F FtsJ PF01728.19 AAS53550.2 - 0.00092 19.4 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase UAF_Rrn10 PF05234.11 AAS53551.1 - 8.7e-30 103.4 0.0 1.1e-29 103.1 0.0 1.0 1 0 0 1 1 1 1 UAF complex subunit Rrn10 zf-C2H2_10 PF16588.5 AAS53552.1 - 8.2e-13 47.8 4.4 1.1e-12 47.4 4.4 1.2 1 0 0 1 1 1 1 C2H2 zinc-finger Thiolase_C PF02803.18 AAS53552.1 - 0.13 11.9 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 Thiolase, C-terminal domain LSM PF01423.22 AAS53553.1 - 8.2e-18 63.9 0.2 1e-17 63.6 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AAS53553.1 - 0.029 14.0 0.0 0.051 13.2 0.0 1.4 1 0 0 1 1 1 0 Hfq protein Phage_prot_Gp6 PF05133.14 AAS53553.1 - 0.065 12.3 0.1 0.072 12.2 0.1 1.0 1 0 0 1 1 1 0 Phage portal protein, SPP1 Gp6-like GDI PF00996.18 AAS53554.1 - 7.2e-228 756.3 0.4 8.2e-228 756.1 0.4 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor NAD_binding_8 PF13450.6 AAS53554.1 - 0.025 14.8 0.0 0.056 13.7 0.0 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain ChaC PF04752.12 AAS53555.1 - 3.7e-50 170.4 0.0 4.3e-50 170.2 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein DUF3235 PF11574.8 AAS53556.2 - 0.083 13.8 0.6 0.083 13.8 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) SbcCD_C PF13558.6 AAS53556.2 - 1.8 8.8 5.0 1.1 9.6 0.4 2.3 1 1 1 2 2 2 0 Putative exonuclease SbcCD, C subunit KH_1 PF00013.29 AAS53557.1 - 8.2e-14 51.2 0.0 1.9e-05 24.4 0.1 5.3 5 0 0 5 5 5 4 KH domain Phlebovirus_G2 PF07245.11 AAS53557.1 - 0.029 12.9 0.0 0.043 12.3 0.0 1.2 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 Citrate_ly_lig PF08218.11 AAS53557.1 - 0.048 13.3 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain Ribosomal_L19 PF01245.20 AAS53557.1 - 0.095 12.6 0.2 0.33 10.9 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein L19 AAA PF00004.29 AAS53559.2 - 1e-93 310.7 0.0 2.7e-47 160.5 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS53559.2 - 8.6e-21 73.5 1.6 3.3e-09 36.4 0.2 2.8 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AAS53559.2 - 1.3e-14 54.3 0.0 2.8e-07 30.4 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AAS53559.2 - 7.8e-13 49.2 2.1 6.7e-05 23.3 0.0 4.0 3 2 0 3 3 2 2 AAA ATPase domain AAA_2 PF07724.14 AAS53559.2 - 5.4e-11 42.9 0.0 0.00044 20.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 AAS53559.2 - 2.4e-10 40.8 0.1 0.0073 16.6 0.0 4.8 2 2 2 4 4 4 2 AAA domain AAA_33 PF13671.6 AAS53559.2 - 1.2e-09 38.5 0.0 0.00041 20.5 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AAS53559.2 - 1.6e-09 37.9 0.1 0.0017 18.3 0.0 3.7 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 AAS53559.2 - 3.8e-09 36.4 0.0 0.00013 21.9 0.0 2.8 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain TIP49 PF06068.13 AAS53559.2 - 8.7e-09 35.0 0.0 0.00033 20.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 AAS53559.2 - 5.5e-08 33.4 0.0 0.003 18.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 AAS53559.2 - 8.6e-08 32.3 0.0 0.022 14.8 0.0 3.1 3 0 0 3 3 2 2 AAA domain ABC_tran PF00005.27 AAS53559.2 - 1.3e-07 32.2 0.0 0.014 15.9 0.0 3.3 3 0 0 3 3 3 2 ABC transporter RNA_helicase PF00910.22 AAS53559.2 - 1.4e-07 31.9 0.0 0.012 16.0 0.0 3.0 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 AAS53559.2 - 7.4e-07 28.6 0.0 0.044 13.1 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.17 AAS53559.2 - 2e-06 27.7 0.1 0.044 13.5 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein Rad17 PF03215.15 AAS53559.2 - 2.5e-06 27.5 0.0 0.009 16.0 0.0 2.5 2 0 0 2 2 2 2 Rad17 P-loop domain Mg_chelatase PF01078.21 AAS53559.2 - 3.5e-06 26.6 0.3 0.05 13.0 0.0 2.3 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AAS53559.2 - 3.9e-06 27.2 0.1 0.064 13.5 0.0 2.8 3 0 0 3 3 2 2 AAA domain AAA_3 PF07726.11 AAS53559.2 - 1.5e-05 24.9 0.0 0.083 12.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 AAS53559.2 - 6.4e-05 22.6 0.0 1.5 8.4 0.0 4.1 4 0 0 4 4 4 1 AAA domain TsaE PF02367.17 AAS53559.2 - 6.4e-05 22.9 0.0 0.52 10.3 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 AAS53559.2 - 0.0001 22.3 0.1 0.76 9.7 0.0 3.1 3 0 0 3 3 2 2 NACHT domain Cytidylate_kin2 PF13189.6 AAS53559.2 - 0.00014 22.1 0.0 0.0057 16.8 0.0 2.5 2 0 0 2 2 2 1 Cytidylate kinase-like family SKI PF01202.22 AAS53559.2 - 0.00016 21.8 0.0 0.25 11.5 0.0 3.0 3 0 0 3 3 2 1 Shikimate kinase AAA_7 PF12775.7 AAS53559.2 - 0.00017 21.1 0.0 0.73 9.3 0.0 3.0 3 0 0 3 3 3 2 P-loop containing dynein motor region AAA_17 PF13207.6 AAS53559.2 - 0.00029 21.3 3.0 0.14 12.6 0.0 3.4 4 1 0 4 4 2 1 AAA domain Viral_helicase1 PF01443.18 AAS53559.2 - 0.00035 20.4 0.0 1.1 9.0 0.0 2.5 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase DUF815 PF05673.13 AAS53559.2 - 0.00045 19.5 0.0 0.14 11.3 0.0 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_24 PF13479.6 AAS53559.2 - 0.00054 19.7 0.0 0.85 9.3 0.0 2.5 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 AAS53559.2 - 0.00055 19.7 0.0 0.27 10.9 0.0 2.8 2 1 1 3 3 3 1 Sigma-54 interaction domain AAA_11 PF13086.6 AAS53559.2 - 0.00073 19.4 1.3 0.8 9.4 0.0 2.9 3 0 0 3 3 3 2 AAA domain ATPase_2 PF01637.18 AAS53559.2 - 0.00074 19.5 0.1 2.4 8.0 0.0 3.7 4 1 1 5 5 4 1 ATPase domain predominantly from Archaea CPT PF07931.12 AAS53559.2 - 0.0009 19.1 0.0 0.021 14.7 0.0 2.4 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein NB-ARC PF00931.22 AAS53559.2 - 0.0012 18.0 0.0 1 8.5 0.0 2.9 3 0 0 3 3 3 1 NB-ARC domain ATPase PF06745.13 AAS53559.2 - 0.0016 17.8 0.0 1.6 8.0 0.0 3.2 3 0 0 3 3 3 1 KaiC Parvo_NS1 PF01057.17 AAS53559.2 - 0.0025 17.0 0.1 1.9 7.5 0.0 2.4 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 Cytidylate_kin PF02224.18 AAS53559.2 - 0.0043 16.8 0.1 0.4 10.4 0.0 2.8 2 0 0 2 2 2 1 Cytidylate kinase Sigma54_activ_2 PF14532.6 AAS53559.2 - 0.0045 17.1 0.0 2.8 8.0 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain SRPRB PF09439.10 AAS53559.2 - 0.0069 15.8 0.0 2 7.8 0.0 2.9 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit PduV-EutP PF10662.9 AAS53559.2 - 0.013 15.3 0.0 5.5 6.7 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Phage_Gp17 PF17549.2 AAS53559.2 - 0.015 15.3 0.7 0.044 13.8 0.7 1.7 1 0 0 1 1 1 0 Gene Product 17 AFG1_ATPase PF03969.16 AAS53559.2 - 0.027 13.3 0.0 9.1 5.1 0.0 2.7 3 0 0 3 3 3 0 AFG1-like ATPase NTPase_1 PF03266.15 AAS53559.2 - 0.028 14.4 0.0 12 5.7 0.0 2.9 3 0 0 3 3 2 0 NTPase PhoH PF02562.16 AAS53559.2 - 0.031 13.7 0.2 2.8 7.3 0.0 2.4 2 0 0 2 2 2 0 PhoH-like protein Hydin_ADK PF17213.3 AAS53559.2 - 0.032 14.5 0.1 0.45 10.8 0.0 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain AAA_19 PF13245.6 AAS53559.2 - 0.039 14.3 0.0 11 6.4 0.0 2.6 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 AAS53559.2 - 0.053 13.0 0.1 1.9 8.0 0.0 2.6 2 0 0 2 2 2 0 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AAS53559.2 - 0.07 13.0 0.3 1 9.3 0.0 2.6 3 0 0 3 3 2 0 RsgA GTPase TniB PF05621.11 AAS53559.2 - 0.097 12.1 0.0 18 4.7 0.0 2.6 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 AAS53559.2 - 0.18 11.9 1.3 3.5 7.7 0.0 3.0 3 0 0 3 3 2 0 50S ribosome-binding GTPase IPT PF01745.16 AAS53559.2 - 0.55 9.6 1.8 24 4.2 0.0 2.7 3 0 0 3 3 3 0 Isopentenyl transferase AAA_23 PF13476.6 AAS53559.2 - 0.93 10.0 6.0 1.2 9.6 0.0 3.3 3 0 0 3 3 2 0 AAA domain CLP1_P PF16575.5 AAS53560.1 - 1.2e-25 90.4 0.2 1e-24 87.4 0.2 2.3 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 AAS53560.1 - 0.0055 16.8 0.0 0.016 15.3 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 AAS53560.1 - 0.014 14.5 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 G-protein alpha subunit AAA_7 PF12775.7 AAS53560.1 - 0.048 13.2 0.5 2.8 7.4 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 AAS53560.1 - 0.088 13.1 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 AAS53560.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS53560.1 - 0.14 11.6 0.0 0.24 10.9 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_21 PF13304.6 AAS53560.1 - 0.19 11.5 0.0 0.35 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system zf-C2H2 PF00096.26 AAS53561.1 - 1.4e-05 25.3 20.7 0.00011 22.5 2.8 3.7 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS53561.1 - 0.00094 19.5 7.5 0.0042 17.4 2.6 2.7 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS53561.1 - 0.0012 19.0 0.8 0.0035 17.6 0.1 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AAS53561.1 - 0.0054 16.7 1.6 0.015 15.2 1.6 1.8 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AAS53561.1 - 0.0057 17.4 2.3 0.0057 17.4 2.3 3.7 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_8 PF15909.5 AAS53561.1 - 0.011 16.0 5.5 0.024 14.9 5.5 1.6 1 0 0 1 1 1 0 C2H2-type zinc ribbon zf-met PF12874.7 AAS53561.1 - 0.011 16.1 2.1 0.018 15.5 0.5 2.2 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 AAS53561.1 - 0.11 12.5 0.9 0.22 11.5 0.9 1.5 1 0 0 1 1 1 0 zinc-finger of a C2HC-type DUF629 PF04780.12 AAS53561.1 - 0.19 10.2 8.6 0.39 9.2 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF629) zf-C2HE PF16278.5 AAS53561.1 - 0.29 11.6 9.0 1.3 9.5 8.1 2.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 AAS53561.1 - 0.37 11.5 5.6 0.82 10.4 5.6 1.6 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats FOXP-CC PF16159.5 AAS53561.1 - 1 10.0 11.4 1.6 9.5 1.5 3.3 1 1 2 3 3 3 0 FOXP coiled-coil domain WSC PF01822.19 AAS53562.2 - 1.7e-07 31.3 6.1 1.7e-07 31.3 6.1 3.3 4 1 0 4 4 4 1 WSC domain TMEM154 PF15102.6 AAS53562.2 - 0.016 15.1 0.0 0.016 15.1 0.0 4.1 1 1 1 3 3 3 0 TMEM154 protein family Hum_adeno_E3A PF05393.11 AAS53562.2 - 0.051 13.6 0.1 0.31 11.0 0.1 2.3 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein Syndecan PF01034.20 AAS53562.2 - 0.19 11.7 0.0 0.4 10.6 0.0 1.4 1 0 0 1 1 1 0 Syndecan domain GET2 PF08690.10 AAS53562.2 - 0.53 9.9 13.2 0.83 9.3 13.2 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 GREB1 PF15782.5 AAS53562.2 - 2.3 5.2 26.6 2.9 4.9 26.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 AAS53562.2 - 5.6 5.4 15.0 7.5 5.0 15.0 1.1 1 0 0 1 1 1 0 Utp14 protein RabGAP-TBC PF00566.18 AAS53563.2 - 0.00026 20.7 3.5 0.074 12.7 0.2 3.5 4 0 0 4 4 4 2 Rab-GTPase-TBC domain baeRF_family5 PF18846.1 AAS53563.2 - 0.2 11.9 1.0 1 9.6 0.2 2.3 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 5 COX5B PF01215.19 AAS53564.1 - 9.3e-64 212.9 0.0 1.1e-63 212.7 0.0 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb Ribosomal_S26e PF01283.19 AAS53565.1 - 4.7e-52 175.0 11.3 5.5e-52 174.8 11.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e PLL PF18587.1 AAS53565.1 - 0.09 12.9 0.1 0.1 12.7 0.1 1.1 1 0 0 1 1 1 0 PTX/LNS-Like (PLL) domain WD40 PF00400.32 AAS53566.1 - 8.6e-15 54.9 3.6 0.0038 18.0 0.1 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53566.1 - 0.00058 20.1 0.1 10 6.5 0.0 4.8 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS53566.1 - 0.019 13.9 0.7 9.5 5.1 0.0 3.2 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein SGL PF08450.12 AAS53566.1 - 0.11 12.1 0.1 14 5.2 0.1 2.3 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region BRCT PF00533.26 AAS53566.1 - 1.2 9.6 4.4 4.9 7.6 0.5 3.3 2 2 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain COX6A PF02046.15 AAS53567.1 - 1.1e-36 125.7 0.5 1.2e-36 125.5 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa MRF_C1 PF13887.6 AAS53567.1 - 0.094 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 TPR_12 PF13424.6 AAS53568.1 - 0.0051 17.1 1.9 11 6.4 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS53568.1 - 0.042 14.4 0.8 0.37 11.3 0.1 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 AAS53568.1 - 2.1 8.6 5.0 4.5 7.5 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_M3 PF01432.20 AAS53569.1 - 5.1e-131 438.1 0.0 6.5e-131 437.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 T6SS_VipA PF05591.12 AAS53569.1 - 0.16 11.8 1.5 2.2 8.1 0.1 2.5 2 0 0 2 2 2 0 Type VI secretion system, VipA, VC_A0107 or Hcp2 Peptidase_M50B PF13398.6 AAS53569.1 - 0.16 11.6 0.1 0.25 10.9 0.1 1.2 1 0 0 1 1 1 0 Peptidase M50B-like DUF2175 PF09943.9 AAS53569.1 - 0.34 11.2 1.7 0.84 10.0 0.3 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) WD40 PF00400.32 AAS53570.1 - 5.5e-44 147.3 19.4 1.7e-07 31.8 1.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53570.1 - 2.5e-11 43.7 1.5 0.011 16.0 0.0 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS53570.1 - 8.9e-07 27.9 8.2 0.0028 16.4 0.0 4.6 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AAS53570.1 - 0.00025 20.1 1.1 1.2 8.0 0.0 3.9 1 1 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AAS53570.1 - 0.00026 21.0 0.8 0.022 14.6 0.1 3.0 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 AAS53570.1 - 0.11 12.5 0.3 20 5.3 0.0 3.8 4 1 1 5 5 5 0 WD40-like Beta Propeller Repeat nos_propeller PF18764.1 AAS53570.1 - 0.13 12.2 0.1 22 5.1 0.0 3.1 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Adaptin_N PF01602.20 AAS53571.2 - 8.6e-116 387.6 15.9 1.1e-115 387.2 15.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 AAS53571.2 - 7.1e-51 172.5 14.4 1.7e-50 171.3 5.9 3.2 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 AAS53571.2 - 1.4e-10 41.4 3.0 1.6e-05 25.2 0.0 5.3 5 1 1 6 6 6 2 HEAT repeats HEAT PF02985.22 AAS53571.2 - 2.2e-09 36.8 0.4 0.025 14.8 0.0 5.1 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.6 AAS53571.2 - 0.0016 18.9 1.4 1.4 9.5 0.0 4.4 5 0 0 5 5 5 1 HEAT-like repeat Atx10homo_assoc PF09759.9 AAS53571.2 - 0.017 15.1 0.6 0.41 10.7 0.1 3.3 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain RTP1_C1 PF10363.9 AAS53571.2 - 0.053 13.7 9.3 0.057 13.6 0.3 5.0 4 1 3 7 7 7 0 Required for nuclear transport of RNA pol II C-terminus 1 Cmc1 PF08583.10 AAS53572.1 - 9e-21 73.7 0.9 1.2e-20 73.3 0.9 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like COX17 PF05051.13 AAS53572.1 - 0.018 15.4 1.3 1.5 9.3 0.3 2.3 2 0 0 2 2 2 0 Cytochrome C oxidase copper chaperone (COX17) L31 PF09784.9 AAS53573.2 - 1.9e-41 140.6 1.5 3.2e-41 139.9 1.5 1.3 1 1 0 1 1 1 1 Mitochondrial ribosomal protein L31 Spc24 PF08286.11 AAS53574.1 - 4.1e-22 78.4 0.1 4.1e-22 78.4 0.1 2.3 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 Tht1 PF04163.12 AAS53574.1 - 0.0086 14.9 2.3 0.011 14.5 2.3 1.1 1 0 0 1 1 1 1 Tht1-like nuclear fusion protein Peptidase_S46 PF10459.9 AAS53574.1 - 0.019 13.6 8.7 0.021 13.5 8.7 1.0 1 0 0 1 1 1 0 Peptidase S46 Lipoprotein_6 PF01441.19 AAS53574.1 - 0.099 12.6 0.8 0.19 11.7 0.4 1.6 1 1 0 1 1 1 0 Lipoprotein DUF3294 PF07957.11 AAS53574.1 - 0.11 12.2 7.8 0.17 11.6 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Atg14 PF10186.9 AAS53574.1 - 0.45 9.6 10.5 0.59 9.2 10.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Peptidase_S64 PF08192.11 AAS53574.1 - 0.98 7.8 4.4 1.2 7.6 4.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF3103 PF11301.8 AAS53574.1 - 1.4 7.7 6.6 1.8 7.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) DUF1690 PF07956.11 AAS53574.1 - 1.7 9.1 16.9 1.1 9.7 15.1 1.6 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) FapA PF03961.13 AAS53574.1 - 1.7 7.1 6.0 2.3 6.7 6.0 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Seryl_tRNA_N PF02403.22 AAS53574.1 - 2.3 8.5 17.1 23 5.3 15.4 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Exonuc_VII_L PF02601.15 AAS53574.1 - 3.4 7.1 12.1 4.4 6.8 12.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF812 PF05667.11 AAS53574.1 - 4.7 6.0 18.4 37 3.0 18.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF812) FUSC PF04632.12 AAS53574.1 - 5.5 5.4 16.2 6.6 5.1 16.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family V_ATPase_I PF01496.19 AAS53574.1 - 6.3 4.6 9.7 7.5 4.3 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Enkurin PF13864.6 AAS53574.1 - 7.1 7.1 13.5 4.6 7.7 11.5 1.8 2 0 0 2 2 2 0 Calmodulin-binding Mobilization_B PF17511.2 AAS53574.1 - 8.1 6.8 15.6 0.66 10.4 1.3 2.2 1 1 1 2 2 2 0 Mobilization protein B DUF2203 PF09969.9 AAS53574.1 - 8.6 7.1 11.1 5.9 7.6 8.9 1.7 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) PRKG1_interact PF15898.5 AAS53574.1 - 9 7.3 18.6 3.6 8.6 1.7 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain DASH_Hsk3 PF08227.11 AAS53575.1 - 9.5e-20 70.7 6.2 1.2e-19 70.3 6.2 1.2 1 0 0 1 1 1 1 DASH complex subunit Hsk3 like MCC-bdg_PDZ PF10506.9 AAS53575.1 - 0.013 15.5 2.5 0.16 12.0 2.5 2.0 1 1 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Synaptonemal_3 PF15191.6 AAS53575.1 - 0.089 12.6 0.7 0.1 12.3 0.7 1.2 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 DUF2205 PF10224.9 AAS53575.1 - 0.12 12.4 2.4 0.17 11.9 2.3 1.4 1 1 0 1 1 1 0 Short coiled-coil protein Pkinase PF00069.25 AAS53576.1 - 3.1e-74 249.6 0.0 3.9e-74 249.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53576.1 - 6.2e-33 114.2 0.0 8.4e-33 113.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS53576.1 - 3.3e-08 32.9 1.2 7.7e-08 31.7 1.2 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 AAS53576.1 - 1.8e-05 24.2 0.0 3.6e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 AAS53576.1 - 0.00062 18.7 0.1 0.0014 17.5 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 AAS53576.1 - 0.0092 15.6 0.1 0.02 14.5 0.1 1.5 1 0 0 1 1 1 1 RIO1 family Seadorna_VP7 PF07387.11 AAS53576.1 - 0.08 12.0 0.2 0.21 10.6 0.1 1.5 1 1 0 1 1 1 0 Seadornavirus VP7 Imm64 PF15600.6 AAS53576.1 - 0.17 11.6 0.3 0.26 10.9 0.3 1.3 1 0 0 1 1 1 0 Immunity protein 64 Abhydrolase_1 PF00561.20 AAS53577.1 - 3.5e-33 115.3 0.2 4.3e-33 115.0 0.2 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydro_lipase PF04083.16 AAS53577.1 - 5.9e-19 67.4 0.1 1.2e-18 66.4 0.1 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Hydrolase_4 PF12146.8 AAS53577.1 - 3.6e-05 23.2 0.0 0.005 16.1 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 FSH1 PF03959.13 AAS53577.1 - 0.049 13.3 0.0 3.8 7.1 0.0 2.3 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Sdh_cyt PF01127.22 AAS53578.1 - 1.8e-27 95.8 3.0 2.2e-27 95.5 3.0 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4748 PF15932.5 AAS53578.1 - 0.14 11.9 0.1 0.35 10.7 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) HALZ PF02183.18 AAS53579.1 - 0.0053 17.0 1.5 0.01 16.1 1.5 1.5 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.15 AAS53579.1 - 0.18 11.6 1.1 0.33 10.7 1.1 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.15 AAS53579.1 - 2.2 8.5 6.5 0.22 11.7 1.5 1.9 2 0 0 2 2 2 0 Basic region leucine zipper Snf7 PF03357.21 AAS53580.1 - 1.1e-48 165.1 14.4 1.1e-48 165.1 14.4 1.9 2 0 0 2 2 2 1 Snf7 PspA_IM30 PF04012.12 AAS53580.1 - 0.015 14.9 14.6 0.15 11.6 14.6 2.2 1 1 0 1 1 1 0 PspA/IM30 family SNARE PF05739.19 AAS53581.2 - 4e-15 55.5 0.5 1e-14 54.2 0.5 1.8 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 AAS53581.2 - 1.7e-06 27.9 11.7 0.0011 18.6 3.0 2.3 2 0 0 2 2 2 2 Syntaxin Syntaxin-18_N PF10496.9 AAS53581.2 - 0.00031 20.9 0.1 0.0011 19.1 0.0 1.9 2 0 0 2 2 2 1 SNARE-complex protein Syntaxin-18 N-terminus MCPsignal PF00015.21 AAS53581.2 - 0.0075 16.1 1.5 0.0075 16.1 1.5 2.6 2 1 1 3 3 3 1 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF16 PF01519.16 AAS53581.2 - 0.017 15.6 0.8 0.017 15.6 0.8 2.2 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 AAS53581.2 - 0.025 14.6 8.3 0.46 10.5 0.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Cluap1 PF10234.9 AAS53581.2 - 0.029 13.8 5.6 0.035 13.5 0.2 2.3 2 0 0 2 2 2 0 Clusterin-associated protein-1 Serine_rich PF08824.10 AAS53581.2 - 0.043 13.8 1.1 12 5.9 0.2 2.6 2 1 0 2 2 2 0 Serine rich protein interaction domain Syntaxin-5_N PF11416.8 AAS53581.2 - 0.11 11.8 0.3 0.11 11.8 0.3 2.7 3 0 0 3 3 3 0 Syntaxin-5 N-terminal, Sly1p-binding domain Dynamitin PF04912.14 AAS53581.2 - 0.14 11.5 6.7 0.047 13.0 0.5 2.3 2 1 0 2 2 2 0 Dynamitin Prominin PF05478.11 AAS53581.2 - 0.22 9.4 3.8 0.075 11.0 0.3 1.8 2 0 0 2 2 2 0 Prominin WXG100 PF06013.12 AAS53581.2 - 0.26 11.6 7.2 0.46 10.7 1.2 2.8 2 0 0 2 2 2 0 Proteins of 100 residues with WXG UPF0242 PF06785.11 AAS53581.2 - 0.85 9.7 10.3 0.21 11.7 2.1 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CdvA PF18822.1 AAS53581.2 - 1.5 8.6 6.9 2.7 7.8 0.2 3.5 2 2 1 3 3 3 0 CdvA-like coiled-coil domain FlaC_arch PF05377.11 AAS53581.2 - 3.4 8.1 8.5 3.3 8.2 0.3 4.3 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) Osmo_CC PF08946.10 AAS53581.2 - 3.8 7.8 7.2 34 4.8 1.4 3.7 3 1 1 4 4 4 0 Osmosensory transporter coiled coil CREPT PF16566.5 AAS53581.2 - 4.8 7.3 7.2 5.4 7.2 0.1 2.7 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour BLOC1_2 PF10046.9 AAS53581.2 - 6.6 7.1 8.5 1.8 8.9 1.4 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Aminotran_1_2 PF00155.21 AAS53582.1 - 3.8e-77 259.9 0.0 4.7e-77 259.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II KAAG1 PF15354.6 AAS53582.1 - 0.065 13.8 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 Kidney-associated antigen 1 BslA PF17735.1 AAS53582.1 - 0.17 11.9 0.0 0.3 11.1 0.0 1.3 1 0 0 1 1 1 0 Biofilm surface layer A zf-C3HC4_3 PF13920.6 AAS53583.2 - 1.3e-08 34.5 11.4 3e-08 33.4 11.4 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DUF2127 PF09900.9 AAS53583.2 - 0.034 14.4 1.5 8.8 6.6 0.5 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2127) Urb2 PF10441.9 AAS53583.2 - 0.04 13.8 0.0 0.097 12.6 0.0 1.6 1 0 0 1 1 1 0 Urb2/Npa2 family Prok-RING_4 PF14447.6 AAS53583.2 - 1.1 9.2 10.8 2.2 8.2 10.8 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 AICARFT_IMPCHas PF01808.18 AAS53584.2 - 2.9e-92 309.3 0.0 4.5e-92 308.7 0.0 1.3 1 0 0 1 1 1 1 AICARFT/IMPCHase bienzyme MGS PF02142.22 AAS53584.2 - 9.3e-25 86.6 0.1 3.1e-24 85.0 0.0 1.9 2 0 0 2 2 2 1 MGS-like domain Ribosomal_L15e PF00827.17 AAS53585.1 - 2.8e-88 294.7 12.2 3.4e-88 294.4 12.2 1.0 1 0 0 1 1 1 1 Ribosomal L15 Period_C PF12114.8 AAS53586.1 - 0.7 9.5 6.0 0.74 9.4 6.0 1.0 1 0 0 1 1 1 0 Period protein 2/3C-terminal region Pkr1 PF08636.10 AAS53587.1 - 1.3e-28 99.0 6.7 1.5e-28 98.7 6.7 1.1 1 0 0 1 1 1 1 ER protein Pkr1 Rhomboid PF01694.22 AAS53587.1 - 0.0009 19.3 1.7 0.0009 19.3 1.7 1.1 1 0 0 1 1 1 1 Rhomboid family DUF5337 PF17272.2 AAS53587.1 - 0.042 13.7 5.8 0.06 13.2 5.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5337) DUF4131 PF13567.6 AAS53587.1 - 0.1 12.3 3.6 0.12 12.1 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FixS PF03597.15 AAS53587.1 - 2 8.2 10.0 3.8 7.3 1.3 2.2 1 1 1 2 2 2 0 Cytochrome oxidase maturation protein cbb3-type AAA_23 PF13476.6 AAS53588.1 - 2 8.9 13.4 5.8 7.4 2.6 2.4 2 0 0 2 2 2 0 AAA domain MIF4G_like PF09088.11 AAS53589.2 - 5.1e-53 179.7 0.8 1.6e-52 178.1 0.8 1.8 2 0 0 2 2 2 1 MIF4G like MIF4G_like_2 PF09090.11 AAS53589.2 - 1.8e-51 175.1 1.9 1.1e-49 169.3 1.9 2.4 1 1 0 1 1 1 1 MIF4G like DUF4129 PF13559.6 AAS53590.1 - 0.0054 17.0 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4129) SNF2_N PF00176.23 AAS53591.2 - 5.5e-67 225.9 0.0 7.7e-67 225.5 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain HIRAN PF08797.11 AAS53591.2 - 5.1e-16 58.4 0.0 1e-15 57.4 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain Helicase_C PF00271.31 AAS53591.2 - 2.1e-13 50.6 0.0 2.4e-12 47.2 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-RING_2 PF13639.6 AAS53591.2 - 2.3e-07 31.0 10.2 5.6e-07 29.8 10.2 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AAS53591.2 - 1.7e-05 24.5 11.6 3.4e-05 23.6 11.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS53591.2 - 0.00013 21.9 10.5 0.00026 20.9 10.5 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 AAS53591.2 - 0.0008 19.4 8.8 0.0016 18.4 8.8 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 AAS53591.2 - 0.014 15.4 2.3 0.031 14.3 2.3 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 AAS53591.2 - 0.022 14.6 9.7 0.048 13.5 9.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AAS53591.2 - 0.38 11.1 5.3 0.92 9.8 5.3 1.6 1 0 0 1 1 1 0 RING-H2 zinc finger domain FANCL_C PF11793.8 AAS53591.2 - 1 9.6 6.6 2.6 8.3 6.6 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_4 PF14570.6 AAS53591.2 - 1.1 9.1 7.0 3.3 7.6 7.0 1.8 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 AAS53591.2 - 1.2 9.3 11.0 2.6 8.3 11.0 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 AAS53591.2 - 1.9 8.4 8.2 3.9 7.4 8.2 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 AAS53591.2 - 8.8 6.2 7.8 20 5.0 7.8 1.7 1 0 0 1 1 1 0 RING-like zinc finger MOZ_SAS PF01853.18 AAS53592.1 - 1.1e-56 191.3 0.3 1.5e-56 190.9 0.3 1.1 1 0 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 AAS53592.1 - 9.5e-07 28.3 6.7 1.4e-05 24.6 0.9 2.9 3 0 0 3 3 3 2 MYST family zinc finger domain Acetyltransf_1 PF00583.25 AAS53592.1 - 0.001 19.3 0.0 0.0058 16.9 0.0 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS53592.1 - 0.016 15.6 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-C2H2_4 PF13894.6 AAS53592.1 - 0.016 16.0 0.8 0.066 14.1 0.8 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS53592.1 - 0.049 14.1 0.9 0.17 12.4 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Acetyltransf_10 PF13673.7 AAS53592.1 - 0.19 11.7 0.0 0.35 10.8 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain HA2 PF04408.23 AAS53593.2 - 1.2e-29 102.8 0.0 1.2e-29 102.8 0.0 3.2 3 1 0 3 3 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 AAS53593.2 - 6.8e-13 48.9 0.1 7.5e-11 42.4 0.0 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 AAS53593.2 - 1.1e-11 44.9 0.0 3e-11 43.5 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DEAD PF00270.29 AAS53593.2 - 3.4e-08 33.4 0.0 8e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS53593.2 - 1.1e-05 25.7 0.2 4.6e-05 23.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 AAS53593.2 - 0.00095 18.6 0.0 0.0028 17.0 0.0 1.7 1 0 0 1 1 1 1 KaiC AAA_19 PF13245.6 AAS53593.2 - 0.0029 18.0 0.0 0.0073 16.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS53593.2 - 0.0063 17.1 1.8 0.54 10.8 0.0 3.3 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 AAS53593.2 - 0.015 14.4 0.0 0.028 13.5 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 AAS53593.2 - 0.024 14.4 0.0 0.062 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 AAS53593.2 - 0.05 13.0 0.0 0.13 11.7 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.6 AAS53593.2 - 0.059 13.5 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 AAS53593.2 - 0.094 12.0 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Flavi_DEAD PF07652.14 AAS53593.2 - 0.13 12.2 0.3 0.52 10.3 0.1 2.2 1 1 1 2 2 2 0 Flavivirus DEAD domain SAPS PF04499.15 AAS53593.2 - 0.6 8.8 19.2 0.069 11.9 13.7 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Bromodomain PF00439.25 AAS53594.2 - 8.5e-07 29.0 0.0 2e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Bromodomain Nramp PF01566.18 AAS53595.1 - 3.3e-96 322.4 17.2 4.3e-96 322.0 17.2 1.1 1 0 0 1 1 1 1 Natural resistance-associated macrophage protein EMP24_GP25L PF01105.24 AAS53596.1 - 0.0062 16.5 2.8 0.028 14.4 0.1 2.9 2 1 0 2 2 2 1 emp24/gp25L/p24 family/GOLD hGDE_N PF14699.6 AAS53596.1 - 0.094 12.9 0.2 19 5.5 0.0 4.0 3 0 0 3 3 3 0 N-terminal domain from the human glycogen debranching enzyme HATPase_c_3 PF13589.6 AAS53597.1 - 1.4e-11 44.3 0.0 3.6e-11 43.1 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DNA_mis_repair PF01119.19 AAS53597.1 - 5.2e-10 39.0 0.0 1.2e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain HATPase_c PF02518.26 AAS53597.1 - 5.1e-06 27.0 0.1 1e-05 26.0 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAD_2 PF13419.6 AAS53598.2 - 1.1e-07 32.1 0.0 1.6e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AAS53598.2 - 1.4e-07 31.4 0.0 2.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AAS53598.2 - 1.2e-06 29.0 0.0 1.6e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PTR2 PF00854.21 AAS53599.1 - 2.1e-43 148.6 4.4 3.1e-43 148.1 4.4 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 AAS53599.1 - 8.4e-10 38.1 18.9 1.2e-05 24.5 0.5 2.5 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_1 PF07690.16 AAS53600.1 - 3.5e-10 39.4 21.1 6.2e-10 38.5 21.1 1.4 1 0 0 1 1 1 1 Major Facilitator Superfamily V_ATPase_I PF01496.19 AAS53600.1 - 0.0076 14.2 0.1 0.011 13.8 0.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family AA_permease PF00324.21 AAS53601.1 - 2.1e-142 475.1 31.3 2.4e-142 474.9 31.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS53601.1 - 5.3e-44 150.7 30.2 7.2e-44 150.3 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease PNRC PF15365.6 AAS53602.1 - 0.12 12.2 4.3 0.71 9.8 4.3 2.4 1 1 0 1 1 1 0 Proline-rich nuclear receptor coactivator motif PT PF04886.12 AAS53602.1 - 1.1 8.9 14.8 0.048 13.2 6.3 2.8 3 0 0 3 3 3 0 PT repeat ABC_tran PF00005.27 AAS53603.2 - 2.6e-49 167.2 0.0 3.1e-24 86.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter ABC_tran_Xtn PF12848.7 AAS53603.2 - 4.1e-22 78.0 2.1 4.1e-22 78.0 2.1 2.8 3 0 0 3 3 2 1 ABC transporter AAA_21 PF13304.6 AAS53603.2 - 1.3e-19 71.2 0.9 7.4e-05 22.7 0.0 4.4 3 1 0 4 4 4 4 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS53603.2 - 9.6e-10 38.3 1.4 0.2 11.1 0.1 4.6 3 1 0 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AAS53603.2 - 2.4e-08 33.6 0.0 0.0015 18.2 0.1 2.4 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_23 PF13476.6 AAS53603.2 - 3.3e-08 34.3 2.8 0.032 14.7 0.0 3.7 3 1 0 3 3 3 2 AAA domain AAA_15 PF13175.6 AAS53603.2 - 2.3e-07 30.9 0.4 0.015 15.0 0.0 2.8 3 0 0 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 AAS53603.2 - 2.3e-07 31.2 0.0 0.043 14.1 0.0 3.1 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 AAS53603.2 - 8.1e-07 29.1 0.5 0.0013 18.7 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase AAA_18 PF13238.6 AAS53603.2 - 3e-06 27.8 0.1 0.048 14.2 0.0 3.6 4 1 0 4 4 3 2 AAA domain AAA_16 PF13191.6 AAS53603.2 - 8.8e-06 26.2 0.0 0.022 15.2 0.0 2.6 2 0 0 2 2 2 2 AAA ATPase domain AAA PF00004.29 AAS53603.2 - 2.2e-05 24.9 0.1 0.28 11.6 0.0 3.5 2 2 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 AAS53603.2 - 4.3e-05 23.6 0.1 0.072 13.2 0.0 3.0 3 0 0 3 3 2 1 50S ribosome-binding GTPase AAA_33 PF13671.6 AAS53603.2 - 5.9e-05 23.3 1.0 0.1 12.7 0.1 3.4 4 0 0 4 4 3 1 AAA domain NACHT PF05729.12 AAS53603.2 - 6.9e-05 22.8 0.2 0.18 11.7 0.0 3.0 3 0 0 3 3 3 2 NACHT domain RNA_helicase PF00910.22 AAS53603.2 - 0.00011 22.5 0.0 0.7 10.3 0.0 2.9 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AAS53603.2 - 0.00046 20.5 0.0 0.38 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 AAS53603.2 - 0.00054 20.0 0.0 1 9.4 0.0 3.1 2 0 0 2 2 2 1 AAA domain MCM PF00493.23 AAS53603.2 - 0.0012 18.0 0.0 0.17 11.0 0.0 2.4 2 0 0 2 2 2 1 MCM P-loop domain AAA_24 PF13479.6 AAS53603.2 - 0.0013 18.5 0.4 1.5 8.5 0.1 3.2 3 0 0 3 3 3 1 AAA domain AAA_27 PF13514.6 AAS53603.2 - 0.003 17.2 0.4 1.3 8.5 0.0 2.8 3 0 0 3 3 2 1 AAA domain Rad17 PF03215.15 AAS53603.2 - 0.0031 17.5 0.0 2.4 8.0 0.0 2.6 2 0 0 2 2 2 1 Rad17 P-loop domain NB-ARC PF00931.22 AAS53603.2 - 0.0031 16.8 0.0 2.6 7.1 0.0 3.2 3 0 0 3 3 3 1 NB-ARC domain AAA_5 PF07728.14 AAS53603.2 - 0.009 16.0 0.1 6.4 6.8 0.2 2.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) MeaB PF03308.16 AAS53603.2 - 0.01 14.8 0.1 1.3 8.0 0.0 2.8 3 0 0 3 3 3 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 AAS53603.2 - 0.014 15.4 1.4 4.1 7.4 0.0 3.8 2 1 1 3 3 3 0 Dynamin family AAA_25 PF13481.6 AAS53603.2 - 0.016 14.8 0.1 1 8.9 0.1 3.3 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 AAS53603.2 - 0.018 14.9 0.2 6.2 6.7 0.0 3.1 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea Roc PF08477.13 AAS53603.2 - 0.019 15.2 0.0 5.8 7.2 0.0 2.8 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase VirE PF05272.11 AAS53603.2 - 0.021 14.5 0.0 1.5 8.5 0.0 2.9 3 0 0 3 3 3 0 Virulence-associated protein E AAA_30 PF13604.6 AAS53603.2 - 0.025 14.3 2.3 1 9.1 0.2 3.7 4 1 0 4 4 4 0 AAA domain DUF815 PF05673.13 AAS53603.2 - 0.037 13.2 0.2 10 5.2 0.0 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 AAS53603.2 - 0.04 13.6 0.0 0.84 9.3 0.0 2.7 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_7 PF12775.7 AAS53603.2 - 0.046 13.2 0.2 3.2 7.2 0.0 2.6 3 0 0 3 3 2 0 P-loop containing dynein motor region TsaE PF02367.17 AAS53603.2 - 0.056 13.5 0.3 15 5.6 0.0 2.8 2 1 1 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NTPase_1 PF03266.15 AAS53603.2 - 0.056 13.4 0.2 2.9 7.8 0.1 2.6 2 0 0 2 2 2 0 NTPase CLP1_P PF16575.5 AAS53603.2 - 0.093 12.5 0.7 9.1 6.0 0.0 3.4 4 0 0 4 4 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop G-alpha PF00503.20 AAS53603.2 - 0.11 11.6 1.4 1.5 7.9 0.0 2.8 2 2 1 4 4 4 0 G-protein alpha subunit DUF87 PF01935.17 AAS53603.2 - 1.7 8.7 7.9 14 5.7 0.0 3.7 4 1 1 5 5 4 0 Helicase HerA, central domain Hydrolase PF00702.26 AAS53605.2 - 1.1e-07 32.4 0.0 8.7e-07 29.4 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase N_formyltrans_C PF18216.1 AAS53605.2 - 0.041 13.6 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 N-formyltransferase dimerization C-terminal domain Nse5 PF08691.10 AAS53606.1 - 3e-83 280.2 3.0 3.4e-83 280.1 3.0 1.0 1 0 0 1 1 1 1 DNA repair proteins Nse5 and Nse6 Not3 PF04065.15 AAS53606.1 - 0.43 10.0 2.4 0.72 9.2 2.4 1.3 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component UAA PF08449.11 AAS53607.2 - 2.8e-11 43.2 21.9 3.4e-11 42.9 21.9 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 AAS53607.2 - 1.4e-08 35.0 33.2 3.7e-06 27.2 11.4 2.1 2 0 0 2 2 2 2 EamA-like transporter family DUF2238 PF09997.9 AAS53607.2 - 0.31 10.8 5.6 0.072 12.9 1.0 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2238) Multi_Drug_Res PF00893.19 AAS53607.2 - 5.1 7.8 17.0 3.3 8.4 7.5 3.0 2 1 0 2 2 2 0 Small Multidrug Resistance protein GATA PF00320.27 AAS53608.2 - 2.4e-14 52.6 3.8 4.7e-14 51.7 3.8 1.5 1 0 0 1 1 1 1 GATA zinc finger XPG_I PF00867.18 AAS53609.1 - 9.9e-23 80.3 0.0 2.1e-22 79.3 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 AAS53609.1 - 0.016 15.6 0.0 0.031 14.7 0.0 1.5 1 0 0 1 1 1 0 XPG N-terminal domain XPG_I_2 PF12813.7 AAS53609.1 - 0.2 11.1 0.0 0.34 10.3 0.0 1.3 1 0 0 1 1 1 0 XPG domain containing PMSR PF01625.21 AAS53610.2 - 6.7e-52 175.7 0.0 8e-52 175.5 0.0 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase COX4 PF02936.14 AAS53611.1 - 1.2e-06 28.6 0.0 1.5e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit IV Ost5 PF05251.12 AAS53612.2 - 5.8e-15 55.3 5.0 6.6e-15 55.1 5.0 1.0 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 SPRY PF00622.28 AAS53613.1 - 5.4e-24 84.6 0.4 1.2e-23 83.5 0.1 1.8 2 0 0 2 2 2 1 SPRY domain CLTH PF10607.9 AAS53613.1 - 9.4e-12 45.0 2.2 1.5e-11 44.4 2.2 1.3 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain LisH PF08513.11 AAS53613.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.7 1 0 0 1 1 1 0 LisH AdoHcyase PF05221.17 AAS53614.1 - 9.7e-132 438.6 0.0 2.9e-74 249.9 0.2 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AAS53614.1 - 1.8e-84 281.7 1.9 2.9e-84 281.0 1.9 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AAS53614.1 - 8.2e-08 31.8 0.1 2.1e-07 30.5 0.1 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AAS53614.1 - 0.0018 17.9 0.1 0.0032 17.1 0.1 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 AAS53614.1 - 0.0025 18.1 0.1 0.0049 17.1 0.1 1.5 1 0 0 1 1 1 1 TrkA-N domain Oxidored_nitro PF00148.19 AAS53614.1 - 0.045 12.5 0.2 0.26 9.9 0.1 2.1 2 0 0 2 2 2 0 Nitrogenase component 1 type Oxidoreductase Urocanase PF01175.18 AAS53614.1 - 0.17 11.5 0.6 0.36 10.5 0.6 1.5 1 0 0 1 1 1 0 Urocanase Rossmann-like domain DR2241 PF18069.1 AAS53615.1 - 0.062 13.2 1.4 0.43 10.5 0.1 2.7 2 0 0 2 2 2 0 DR2241 stabilising domain RGS PF00615.19 AAS53615.1 - 0.41 10.9 4.5 4.3 7.6 1.7 3.1 2 1 0 2 2 2 0 Regulator of G protein signaling domain DUF883 PF05957.13 AAS53615.1 - 1.8 9.2 8.3 29 5.3 0.9 4.4 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF883) SAPS PF04499.15 AAS53616.2 - 7.6e-172 572.5 8.6 1.2e-171 571.8 8.6 1.3 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Not3 PF04065.15 AAS53616.2 - 0.48 9.8 3.4 0.18 11.2 0.3 1.9 2 0 0 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component DnaJ PF00226.31 AAS53617.1 - 1.8e-12 47.2 2.7 3.2e-12 46.4 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain ERp29 PF07749.12 AAS53617.1 - 0.073 14.0 0.2 0.16 12.9 0.2 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Adaptin_binding PF10199.9 AAS53619.1 - 8.2e-09 36.1 0.9 0.0023 18.5 0.2 2.3 1 1 1 2 2 2 2 Alpha and gamma adaptin binding protein p34 DUF1077 PF06417.12 AAS53620.1 - 2.1e-43 147.1 2.4 2.6e-43 146.8 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) CopD PF05425.13 AAS53620.1 - 0.0015 18.9 0.8 0.0022 18.3 0.8 1.2 1 0 0 1 1 1 1 Copper resistance protein D THUMP PF02926.17 AAS53621.1 - 1.2e-22 80.6 0.9 1.2e-22 80.6 0.9 1.7 1 1 1 2 2 2 1 THUMP domain ARD PF03079.14 AAS53621.1 - 0.078 13.2 2.7 0.18 12.0 0.0 2.3 1 1 1 2 2 2 0 ARD/ARD' family Sec15 PF04091.12 AAS53622.2 - 2e-102 342.8 13.2 2e-102 342.8 13.2 2.5 3 0 0 3 3 3 1 Exocyst complex subunit Sec15-like HSBP1 PF06825.12 AAS53622.2 - 0.025 14.4 0.9 0.11 12.3 0.9 2.2 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Sec8_exocyst PF04048.14 AAS53622.2 - 3.6 7.5 10.4 44 4.0 8.4 3.3 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Peptidase_M20 PF01546.28 AAS53623.1 - 1.9e-32 112.7 0.0 2.7e-32 112.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AAS53623.1 - 1.4e-11 44.2 0.0 2.5e-11 43.5 0.0 1.3 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AAS53623.1 - 5.3e-05 23.0 0.0 9.3e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Mito_carr PF00153.27 AAS53624.1 - 3.7e-38 129.4 6.6 1.4e-19 69.8 0.2 4.5 3 2 0 3 3 3 3 Mitochondrial carrier protein DUF2391 PF09622.10 AAS53624.1 - 0.1 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative integral membrane protein (DUF2391) Serine_protease PF18405.1 AAS53624.1 - 0.12 11.5 0.3 0.56 9.3 0.1 2.2 2 1 0 2 2 2 0 Gammaproteobacterial serine protease GARS_A PF01071.19 AAS53625.2 - 2.1e-79 265.8 0.0 3.1e-79 265.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 AAS53625.2 - 2.2e-34 118.1 0.1 9.3e-34 116.1 0.0 2.2 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, N domain AIRS_C PF02769.22 AAS53625.2 - 4.4e-33 114.6 0.0 1.2e-32 113.2 0.0 1.8 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain GARS_C PF02843.16 AAS53625.2 - 6.2e-26 90.5 0.4 1.8e-25 89.0 0.4 1.9 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AIRS PF00586.24 AAS53625.2 - 2.5e-17 63.3 4.5 5.3e-17 62.3 2.7 2.4 3 0 0 3 3 3 1 AIR synthase related protein, N-terminal domain ATP-grasp PF02222.22 AAS53625.2 - 7.5e-06 25.6 0.0 1.3e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 AAS53625.2 - 0.00036 20.6 0.0 0.0014 18.7 0.0 2.0 2 1 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AAS53625.2 - 0.0022 17.6 0.0 0.0035 16.9 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.11 AAS53625.2 - 0.016 14.8 0.0 0.038 13.6 0.0 1.6 1 0 0 1 1 1 0 RimK-like ATP-grasp domain GIDA PF01134.22 AAS53626.2 - 2.9e-149 497.5 0.0 3.8e-149 497.1 0.0 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A GIDA_assoc PF13932.6 AAS53626.2 - 2.3e-65 220.7 0.0 3.4e-65 220.2 0.0 1.3 1 0 0 1 1 1 1 GidA associated domain Pyr_redox_2 PF07992.14 AAS53626.2 - 1.6e-05 24.3 1.0 7.2e-05 22.2 0.4 2.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AAS53626.2 - 0.00079 18.9 0.6 0.0015 18.0 0.6 1.5 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AAS53626.2 - 0.0015 17.7 6.8 0.034 13.2 2.8 2.5 3 0 0 3 3 3 2 FAD binding domain Pyr_redox PF00070.27 AAS53626.2 - 0.002 18.6 0.1 0.0052 17.3 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AAS53626.2 - 0.05 12.9 0.0 0.16 11.2 0.0 1.8 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AAS53626.2 - 0.068 12.7 2.5 1.9 8.0 0.0 2.4 2 1 0 2 2 2 0 FAD dependent oxidoreductase HI0933_like PF03486.14 AAS53626.2 - 0.07 11.8 2.8 2.2 6.9 1.5 2.3 2 0 0 2 2 2 0 HI0933-like protein AlaDh_PNT_C PF01262.21 AAS53626.2 - 0.2 10.9 0.4 0.36 10.1 0.4 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain CENP-T_C PF15511.6 AAS53627.2 - 0.0076 16.4 0.0 0.02 15.0 0.0 1.7 1 1 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFB_NFYA PF02045.15 AAS53628.1 - 1.3e-26 93.0 9.4 2.3e-26 92.2 9.4 1.4 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B Proteasome PF00227.26 AAS53629.1 - 2.4e-21 76.1 0.1 2.9e-21 75.8 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit PDEase_II PF02112.15 AAS53630.1 - 1.7e-59 201.7 0.0 2.5e-59 201.1 0.0 1.2 1 0 0 1 1 1 1 cAMP phosphodiesterases class-II Lactamase_B_2 PF12706.7 AAS53630.1 - 5e-07 29.4 0.1 8.5e-07 28.7 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain S36_mt PF10937.8 AAS53631.1 - 4.3e-25 89.5 0.0 5.9e-25 89.1 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S36, mitochondrial Brr6_like_C_C PF10104.9 AAS53632.1 - 6.8e-37 126.2 0.5 7.8e-37 126.0 0.5 1.0 1 0 0 1 1 1 1 Di-sulfide bridge nucleocytoplasmic transport domain Abhydrolase_9_N PF15420.6 AAS53632.1 - 0.13 12.2 1.9 5.8 6.9 0.0 2.1 2 0 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus ABC_tran PF00005.27 AAS53632.1 - 0.17 12.4 0.0 0.2 12.2 0.0 1.1 1 0 0 1 1 1 0 ABC transporter RAI1 PF08652.11 AAS53633.1 - 2.3e-29 101.4 1.1 2.1e-17 63.1 0.2 2.5 2 0 0 2 2 2 2 RAI1 like PD-(D/E)XK nuclease DUF3870 PF12986.7 AAS53633.1 - 0.0089 16.2 0.0 0.31 11.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3870) RAI1 PF08652.11 AAS53634.1 - 2.2e-23 82.2 0.2 3.9e-23 81.4 0.2 1.4 1 0 0 1 1 1 1 RAI1 like PD-(D/E)XK nuclease tRNA-synt_1c PF00749.21 AAS53635.2 - 7.2e-121 402.9 0.1 9.1e-121 402.6 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 AAS53635.2 - 2.2e-37 128.6 0.0 4.3e-37 127.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain GluRS_N PF18466.1 AAS53635.2 - 2.5e-09 37.4 0.1 7.4e-09 35.9 0.1 1.9 1 0 0 1 1 1 1 Glutamate--tRNA ligase N-terminal domain GST_C_2 PF13410.6 AAS53635.2 - 3.7e-05 23.7 0.0 0.00012 22.0 0.0 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 AAS53635.2 - 0.0039 17.4 0.1 0.017 15.4 0.0 2.1 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain tRNA-synt_1e PF01406.19 AAS53635.2 - 0.083 12.2 0.1 0.15 11.4 0.1 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF155 PF02582.14 AAS53636.2 - 1.7e-53 181.3 0.1 4.5e-53 179.9 0.0 1.8 2 0 0 2 2 2 1 Uncharacterised ACR, YagE family COG1723 SecG PF03840.14 AAS53636.2 - 0.19 11.9 2.0 0.23 11.6 0.6 1.8 2 0 0 2 2 2 0 Preprotein translocase SecG subunit Plus-3 PF03126.18 AAS53637.1 - 1.5e-28 99.5 0.0 4.1e-28 98.1 0.0 1.8 1 0 0 1 1 1 1 Plus-3 domain A_deamin PF02137.18 AAS53638.1 - 2.6e-30 106.0 0.0 3.4e-30 105.6 0.0 1.1 1 0 0 1 1 1 1 Adenosine-deaminase (editase) domain SNAD4 PF18750.1 AAS53638.1 - 0.0079 16.3 0.0 0.14 12.3 0.1 2.8 2 1 0 2 2 2 1 Secreted Novel AID/APOBEC-like Deaminase 4 NAD1 PF18778.1 AAS53638.1 - 0.0079 16.3 0.1 0.32 11.0 0.1 2.8 2 1 0 2 2 2 1 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 AAS53638.1 - 0.008 16.1 0.0 0.069 13.0 0.0 2.1 2 0 0 2 2 2 1 APOBEC-like N-terminal domain APOBEC2 PF18772.1 AAS53638.1 - 0.01 15.9 0.0 0.093 12.8 0.1 2.4 2 1 0 2 2 2 0 APOBEC2 dCMP_cyt_deam_1 PF00383.23 AAS53638.1 - 0.034 14.0 0.1 0.15 12.0 0.1 2.1 1 1 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region Ank_3 PF13606.6 AAS53639.1 - 8.5e-09 35.0 0.7 0.0078 16.6 0.2 3.5 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 AAS53639.1 - 1.9e-08 34.7 0.0 2.6e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 AAS53639.1 - 1.8e-07 31.3 0.2 0.036 14.5 0.0 3.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 AAS53639.1 - 7.3e-07 29.6 1.9 0.0011 19.5 0.3 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 AAS53639.1 - 8.9e-05 22.7 3.2 0.065 13.6 0.1 3.6 3 1 1 4 4 4 2 Ankyrin repeats (many copies) IBN_N PF03810.19 AAS53640.3 - 2.1e-06 27.6 0.0 9.1e-06 25.5 0.0 2.3 1 0 0 1 1 1 1 Importin-beta N-terminal domain Atx10homo_assoc PF09759.9 AAS53640.3 - 0.0073 16.3 0.3 0.24 11.4 0.2 2.7 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Herpes_gE PF02480.16 AAS53640.3 - 0.13 11.0 0.1 0.24 10.1 0.1 1.4 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DUF4965 PF16335.5 AAS53641.2 - 0.026 14.2 0.0 0.042 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4965) ArsD PF06953.11 AAS53641.2 - 0.18 12.2 0.1 6.4 7.2 0.0 2.3 2 0 0 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD QRPTase_C PF01729.19 AAS53642.2 - 1.2e-58 197.7 0.0 1.5e-58 197.3 0.0 1.1 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 AAS53642.2 - 4.3e-19 68.4 0.0 1.1e-18 67.0 0.0 1.7 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain TMP-TENI PF02581.17 AAS53642.2 - 0.083 12.2 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase PHB_depo_C PF06850.11 AAS53642.2 - 0.18 11.2 0.0 0.28 10.6 0.0 1.2 1 0 0 1 1 1 0 PHB de-polymerase C-terminus ANAPC10 PF03256.16 AAS53643.1 - 9.9e-43 145.9 0.0 1.2e-42 145.7 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) F5_F8_type_C PF00754.25 AAS53643.1 - 0.00027 21.1 0.0 0.0005 20.2 0.0 1.4 1 0 0 1 1 1 1 F5/8 type C domain Cse1 PF08506.10 AAS53644.2 - 4.6e-178 591.7 9.2 4.6e-178 591.7 9.2 1.6 2 0 0 2 2 2 1 Cse1 CAS_CSE1 PF03378.15 AAS53644.2 - 7.5e-108 360.9 4.0 7.5e-108 360.9 4.0 1.7 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus IBN_N PF03810.19 AAS53644.2 - 3.4e-15 55.7 0.2 3.8e-14 52.4 0.0 2.8 2 0 0 2 2 2 1 Importin-beta N-terminal domain Xpo1 PF08389.12 AAS53644.2 - 0.0011 19.1 0.4 0.11 12.6 0.0 3.9 3 2 0 3 3 3 1 Exportin 1-like protein RPAP3_C PF13877.6 AAS53644.2 - 0.15 12.6 0.2 3.3 8.3 0.0 3.4 2 1 1 3 3 3 0 Potential Monad-binding region of RPAP3 Adap_comp_sub PF00928.21 AAS53645.1 - 2.8e-12 46.6 0.2 4.2e-12 46.0 0.2 1.2 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AAS53645.1 - 2.5e-07 30.7 0.5 6.1e-07 29.5 0.5 1.7 1 0 0 1 1 1 1 Clathrin adaptor complex small chain zf-rbx1 PF12678.7 AAS53646.1 - 1.5e-08 34.7 6.4 3.1e-08 33.8 6.4 1.5 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 AAS53646.1 - 4.3e-08 33.4 7.9 1.2e-07 31.9 7.9 1.8 1 1 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AAS53646.1 - 1.7e-06 27.7 6.8 5e-06 26.3 6.8 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS53646.1 - 3.4e-06 26.9 4.3 6.6e-06 26.0 4.3 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 AAS53646.1 - 9.4e-06 25.4 2.8 9.4e-06 25.4 2.8 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS53646.1 - 0.00034 20.6 5.0 0.00084 19.3 5.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 AAS53646.1 - 0.00067 19.5 6.5 0.0027 17.5 6.3 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 AAS53646.1 - 0.0018 18.1 6.9 0.0094 15.8 7.0 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AAS53646.1 - 0.0021 17.7 6.3 0.016 14.9 1.0 2.8 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 AAS53646.1 - 0.021 14.8 3.0 0.054 13.6 3.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger SplA PF11132.8 AAS53646.1 - 0.089 12.6 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator protein (SplA) Trm112p PF03966.16 AAS53646.1 - 0.18 12.4 0.7 11 6.7 0.0 2.7 2 0 0 2 2 2 0 Trm112p-like protein FANCL_C PF11793.8 AAS53646.1 - 0.23 11.7 5.4 0.9 9.8 5.4 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Zn_ribbon_17 PF17120.5 AAS53646.1 - 1.8 8.2 8.1 0.082 12.5 1.9 2.0 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF2420 PF10336.9 AAS53647.2 - 1.7e-37 127.7 0.2 2.9e-37 127.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2420) Ppx-GppA PF02541.16 AAS53648.1 - 1.1e-65 221.9 0.0 1.4e-65 221.6 0.0 1.1 1 0 0 1 1 1 1 Ppx/GppA phosphatase family DUF1699 PF08004.11 AAS53648.1 - 0.052 13.2 0.0 0.18 11.5 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1699) CSN8_PSD8_EIF3K PF10075.9 AAS53649.1 - 9.3e-19 67.8 0.3 1.4e-18 67.2 0.3 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family SAC3_GANP PF03399.16 AAS53649.1 - 0.00027 20.4 0.1 0.00037 20.0 0.1 1.2 1 0 0 1 1 1 1 SAC3/GANP family RRM_8 PF11835.8 AAS53649.1 - 0.086 13.1 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 RRM-like domain RNA_pol_L_2 PF13656.6 AAS53649.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Hexokinase_2 PF03727.16 AAS53650.1 - 4.5e-78 262.0 0.0 8.3e-78 261.1 0.0 1.4 2 0 0 2 2 2 1 Hexokinase Hexokinase_1 PF00349.21 AAS53650.1 - 8.5e-72 241.2 0.0 1.2e-71 240.7 0.0 1.2 1 0 0 1 1 1 1 Hexokinase FGGY_N PF00370.21 AAS53650.1 - 0.018 14.6 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, N-terminal domain ERCC3_RAD25_C PF16203.5 AAS53651.1 - 7.5e-125 415.1 1.0 1.2e-124 414.4 1.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 AAS53651.1 - 2.8e-36 124.5 0.1 6.8e-36 123.2 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53651.1 - 1.5e-15 57.6 0.0 2.9e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AAS53651.1 - 7e-12 45.7 0.1 1.6e-11 44.5 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 AAS53651.1 - 8.7e-09 34.5 0.0 1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain DEAD PF00270.29 AAS53651.1 - 0.00037 20.3 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SBP_bac_6 PF13343.6 AAS53651.1 - 0.015 14.7 0.0 0.038 13.4 0.0 1.6 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Cas_Csm6 PF09659.10 AAS53651.1 - 0.2 10.4 1.1 7 5.3 0.7 2.2 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csm6) Ndc80_HEC PF03801.13 AAS53652.2 - 2.4e-51 173.4 0.8 6.1e-51 172.1 0.0 2.0 2 0 0 2 2 2 1 HEC/Ndc80p family DUF5595 PF18077.1 AAS53652.2 - 1.7e-20 72.9 3.8 1.7e-20 72.9 3.8 4.8 5 1 0 5 5 4 1 Domain of unknown function (DUF5595) Spc7 PF08317.11 AAS53652.2 - 2.6e-05 23.2 37.9 0.00043 19.3 17.5 2.8 2 1 1 3 3 3 2 Spc7 kinetochore protein Rootletin PF15035.6 AAS53652.2 - 0.0017 18.4 9.1 0.0017 18.4 9.1 3.4 3 1 0 3 3 3 1 Ciliary rootlet component, centrosome cohesion DUF3584 PF12128.8 AAS53652.2 - 0.0018 15.9 24.7 0.0049 14.5 7.8 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.15 AAS53652.2 - 0.0029 17.3 26.2 0.04 13.5 8.5 3.1 1 1 2 3 3 3 2 Exonuclease VII, large subunit DUF4200 PF13863.6 AAS53652.2 - 0.0041 17.5 8.2 0.0041 17.5 8.2 4.8 3 2 1 4 4 3 1 Domain of unknown function (DUF4200) DUF5082 PF16888.5 AAS53652.2 - 0.0058 16.9 7.2 0.0058 16.9 7.2 4.6 3 1 2 5 5 5 2 Domain of unknown function (DUF5082) UPF0242 PF06785.11 AAS53652.2 - 0.007 16.5 13.6 0.007 16.5 13.6 3.2 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Baculo_PEP_C PF04513.12 AAS53652.2 - 0.0085 16.1 21.2 0.02 14.9 2.4 4.5 5 0 0 5 5 4 2 Baculovirus polyhedron envelope protein, PEP, C terminus Lipoprotein_20 PF13942.6 AAS53652.2 - 0.011 15.6 2.5 0.011 15.6 2.5 3.5 3 1 1 4 4 3 0 YfhG lipoprotein ATG16 PF08614.11 AAS53652.2 - 0.012 15.8 2.2 0.012 15.8 2.2 4.2 3 2 2 5 5 5 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 AAS53652.2 - 0.026 14.6 36.2 0.47 10.5 0.6 4.9 3 2 1 5 5 4 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.12 AAS53652.2 - 0.037 14.5 20.8 0.084 13.3 0.1 5.5 4 1 1 5 5 5 0 Nucleopolyhedrovirus P10 protein Cluap1 PF10234.9 AAS53652.2 - 0.051 13.0 33.5 0.39 10.1 16.3 4.4 3 2 0 3 3 3 0 Clusterin-associated protein-1 CARD PF00619.21 AAS53652.2 - 0.061 13.4 4.6 0.055 13.5 1.4 2.6 2 0 0 2 2 2 0 Caspase recruitment domain COG2 PF06148.11 AAS53652.2 - 0.064 13.3 24.7 0.26 11.4 0.2 5.2 2 2 2 5 5 5 0 COG (conserved oligomeric Golgi) complex component, COG2 TMPIT PF07851.13 AAS53652.2 - 0.3 10.3 23.7 0.023 14.0 5.0 2.8 2 1 0 2 2 2 0 TMPIT-like protein Lebercilin PF15619.6 AAS53652.2 - 0.39 10.4 33.7 2 8.0 18.9 3.5 2 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4407 PF14362.6 AAS53652.2 - 0.41 10.0 16.0 0.096 12.0 5.0 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4407) Filament PF00038.21 AAS53652.2 - 0.75 9.3 29.2 1.7 8.1 7.7 2.8 2 1 1 3 3 3 0 Intermediate filament protein ISG65-75 PF11727.8 AAS53652.2 - 1.3 8.1 12.8 2.5 7.2 1.7 2.4 2 0 0 2 2 2 0 Invariant surface glycoprotein DUF2203 PF09969.9 AAS53652.2 - 3.7 8.3 21.7 5.9 7.6 1.9 4.0 2 2 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) DUF948 PF06103.11 AAS53652.2 - 3.9 7.8 13.8 5.7 7.3 0.1 4.4 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) ApoO PF09769.9 AAS53652.2 - 7.5 6.5 10.0 58 3.7 1.6 4.2 2 2 2 4 4 4 0 Apolipoprotein O Sec2p PF06428.11 AAS53652.2 - 8.5 6.4 25.8 1.6 8.7 2.1 4.4 3 1 1 4 4 4 0 GDP/GTP exchange factor Sec2p Pantoate_ligase PF02569.15 AAS53653.2 - 2.5e-92 308.8 0.0 2.9e-92 308.7 0.0 1.0 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase HATPase_c PF02518.26 AAS53655.2 - 2.1e-27 95.9 0.1 1.3e-20 74.0 0.0 2.6 2 0 0 2 2 2 2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 AAS53655.2 - 1.4e-26 92.8 0.2 2.9e-26 91.8 0.2 1.6 1 0 0 1 1 1 1 Response regulator receiver domain HisKA PF00512.25 AAS53655.2 - 1.1e-12 47.7 0.2 3.6e-12 46.1 0.2 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HAMP PF00672.25 AAS53655.2 - 0.00022 21.5 0.1 0.072 13.5 0.0 2.6 2 0 0 2 2 2 2 HAMP domain Git3 PF11710.8 AAS53655.2 - 0.077 12.8 1.0 0.15 11.8 1.0 1.4 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 Bindin PF02084.15 AAS53655.2 - 0.15 12.3 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Bindin ubiquitin PF00240.23 AAS53656.1 - 1.5e-34 117.6 0.5 1.9e-34 117.2 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin family Ribosomal_L40e PF01020.17 AAS53656.1 - 1.2e-30 105.1 11.3 1.8e-30 104.5 11.3 1.3 1 0 0 1 1 1 1 Ribosomal L40e family Rad60-SLD PF11976.8 AAS53656.1 - 2.9e-16 59.1 0.6 4.5e-16 58.4 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AAS53656.1 - 2.1e-05 24.9 0.1 7.7e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AAS53656.1 - 0.0043 17.1 0.1 0.0089 16.1 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 AAS53656.1 - 0.0047 16.8 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 AAS53656.1 - 0.0056 17.0 0.0 0.0084 16.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 AAS53656.1 - 0.014 15.4 1.1 4 7.5 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 AAS53656.1 - 0.025 15.1 0.1 0.031 14.8 0.1 1.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain TPR_MLP1_2 PF07926.12 AAS53657.1 - 3.2e-26 91.9 28.4 3.2e-26 91.9 28.4 18.6 7 4 7 16 16 16 6 TPR/MLP1/MLP2-like protein DUF3800 PF12686.7 AAS53657.1 - 0.00032 21.3 0.0 14 6.4 0.0 6.8 1 1 0 1 1 1 1 Protein of unknown function (DUF3800) Pox_A_type_inc PF04508.12 AAS53657.1 - 0.29 11.1 19.4 0.79 9.7 0.1 7.9 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat zf-primase PF09329.11 AAS53658.1 - 3e-14 52.5 0.1 6.1e-14 51.6 0.1 1.6 1 0 0 1 1 1 1 Primase zinc finger BRCA-2_OB1 PF09103.10 AAS53658.1 - 0.003 17.5 0.0 0.0079 16.1 0.0 1.7 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 DUF5088 PF17008.5 AAS53658.1 - 0.0048 16.6 0.5 0.0096 15.7 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF5088) tRNA_anti-codon PF01336.25 AAS53658.1 - 0.006 16.6 0.0 0.014 15.3 0.0 1.6 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DAGK_cat PF00781.24 AAS53659.2 - 2e-12 46.8 0.0 4.1e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Pcc1 PF09341.10 AAS53660.1 - 3.3e-20 72.0 0.5 3.6e-20 71.9 0.5 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 PIN_4 PF13638.6 AAS53661.2 - 1e-13 51.7 1.0 1.6e-13 51.0 0.1 1.8 2 0 0 2 2 2 1 PIN domain SpoIIIAH PF12685.7 AAS53661.2 - 0.11 12.3 2.7 0.2 11.4 2.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Imm31 PF15591.6 AAS53662.1 - 0.15 11.9 0.2 0.29 11.0 0.2 1.5 1 0 0 1 1 1 0 Immunity protein 31 PEPCK_ATP PF01293.20 AAS53663.1 - 1.6e-215 716.2 0.0 1.8e-215 716.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_33 PF13671.6 AAS53663.1 - 0.006 16.7 0.0 0.014 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain PTPA PF03095.15 AAS53664.1 - 3.7e-101 338.6 0.0 4.2e-101 338.4 0.0 1.0 1 0 0 1 1 1 1 Phosphotyrosyl phosphate activator (PTPA) protein DAO PF01266.24 AAS53666.2 - 8e-51 173.7 0.0 1.2e-50 173.1 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 AAS53666.2 - 5.3e-40 136.2 0.0 1e-39 135.3 0.0 1.5 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 AAS53666.2 - 1.1e-12 47.8 2.8 4.5e-12 45.8 2.8 1.8 1 1 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AAS53666.2 - 1.1e-08 34.9 2.9 6.3e-05 22.5 0.2 2.6 3 0 0 3 3 3 2 FAD dependent oxidoreductase GIDA PF01134.22 AAS53666.2 - 3.2e-05 23.2 0.3 0.0056 15.8 0.1 2.2 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AAS53666.2 - 0.00028 20.2 0.1 0.0086 15.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AAS53666.2 - 0.00029 20.2 0.1 0.48 9.6 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Thi4 PF01946.17 AAS53666.2 - 0.001 18.3 0.5 0.064 12.5 0.0 2.3 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 AAS53666.2 - 0.0012 17.6 0.3 0.002 16.9 0.3 1.2 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_8 PF13450.6 AAS53666.2 - 0.0021 18.3 0.4 0.0058 16.8 0.4 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 AAS53666.2 - 0.038 13.3 0.0 0.1 11.8 0.0 1.6 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AAS53666.2 - 0.078 12.3 0.0 0.22 10.8 0.0 1.7 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain GMC_oxred_N PF00732.19 AAS53666.2 - 0.13 11.6 0.1 0.3 10.4 0.1 1.5 1 0 0 1 1 1 0 GMC oxidoreductase UCH PF00443.29 AAS53667.2 - 9.8e-57 192.4 5.0 1.5e-56 191.8 5.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS53667.2 - 3.4e-16 59.8 6.3 7.7e-16 58.6 6.3 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 AAS53667.2 - 0.0087 16.6 0.0 0.022 15.3 0.0 1.7 1 0 0 1 1 1 1 Rhodanese-like domain Myb_DNA-binding PF00249.31 AAS53668.1 - 2.9e-30 104.2 10.0 5.9e-12 45.6 0.5 3.6 3 0 0 3 3 3 3 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS53668.1 - 1.5e-29 102.0 2.9 8.3e-11 42.0 0.0 3.8 2 1 1 3 3 3 3 Myb-like DNA-binding domain SLIDE PF09111.10 AAS53668.1 - 5.8e-06 26.3 1.0 0.49 10.4 0.0 3.9 2 1 2 4 4 4 2 SLIDE Rap1_C PF11626.8 AAS53668.1 - 0.49 10.5 6.0 23 5.2 2.6 3.3 1 1 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF1748 PF08520.10 AAS53669.1 - 9.2e-27 92.7 0.0 1e-26 92.6 0.0 1.0 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1748) Coa1 PF08695.10 AAS53670.1 - 2.8e-36 123.8 0.0 3.5e-36 123.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 SKG6 PF08693.10 AAS53671.1 - 0.02 14.3 2.6 0.037 13.4 2.6 1.4 1 0 0 1 1 1 0 Transmembrane alpha-helix domain HrpF PF06266.12 AAS53671.1 - 0.058 13.7 0.2 0.14 12.5 0.2 1.6 1 0 0 1 1 1 0 HrpF protein EphA2_TM PF14575.6 AAS53671.1 - 0.098 13.5 0.1 0.38 11.7 0.1 2.1 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain MAP17 PF15807.5 AAS53671.1 - 0.24 11.7 1.3 0.77 10.0 0.0 2.3 3 0 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FH2 PF02181.23 AAS53672.1 - 1.2e-71 241.8 4.6 1.2e-71 241.8 4.6 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 AAS53672.1 - 9.5e-07 28.6 0.0 9.5e-07 28.6 0.0 2.5 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 AAS53672.1 - 0.00015 21.5 0.1 0.00015 21.5 0.1 3.3 2 1 1 3 3 3 1 Diaphanous FH3 Domain DUF4407 PF14362.6 AAS53672.1 - 0.0012 18.3 11.5 0.17 11.2 4.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) YjcZ PF13990.6 AAS53672.1 - 0.039 13.3 3.2 0.082 12.3 3.2 1.5 1 0 0 1 1 1 0 YjcZ-like protein PHM7_cyt PF14703.6 AAS53672.1 - 6.2 7.0 8.9 1.2 9.3 3.8 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter NPV_P10 PF05531.12 AAS53672.1 - 7.5 7.1 8.7 15 6.2 0.2 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein HeLo PF14479.6 AAS53672.1 - 7.8 6.3 20.2 0.059 13.2 2.7 3.5 2 1 1 3 3 3 0 Prion-inhibition and propagation Fez1 PF06818.15 AAS53672.1 - 9.2 6.7 21.0 0.13 12.6 7.7 3.0 2 1 0 2 2 2 0 Fez1 Thiolase_N PF00108.23 AAS53673.1 - 2.1e-81 273.1 0.1 3.1e-81 272.6 0.1 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AAS53673.1 - 8.5e-47 157.8 0.7 1.6e-46 157.0 0.7 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AAS53673.1 - 0.00038 20.1 0.1 0.0023 17.5 0.0 2.1 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III PF08545.10 AAS53673.1 - 0.56 10.1 3.1 4 7.4 0.0 2.9 3 0 0 3 3 3 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Asn_synthase PF00733.21 AAS53674.1 - 1e-93 314.8 0.1 8e-54 183.6 0.0 2.1 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AAS53674.1 - 4.7e-33 113.7 0.0 7.8e-33 113.0 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AAS53674.1 - 1.9e-27 96.1 0.0 3.7e-27 95.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 AAS53674.1 - 0.00016 21.2 0.0 0.00031 20.3 0.0 1.4 1 0 0 1 1 1 1 Aluminium induced protein NAD_synthase PF02540.17 AAS53674.1 - 0.036 13.2 0.0 0.062 12.4 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Sulfate_transp PF00916.20 AAS53675.2 - 4e-69 233.2 19.1 6.9e-69 232.4 19.1 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AAS53675.2 - 4.7e-11 42.3 1.1 1.1e-10 41.2 1.1 1.6 1 0 0 1 1 1 1 STAS domain cNMP_binding PF00027.29 AAS53675.2 - 0.0021 18.1 0.0 0.0043 17.1 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF4191 PF13829.6 AAS53675.2 - 2.3 7.5 3.7 3.3 7.0 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) MFS_MOT1 PF16983.5 AAS53675.2 - 4.5 7.7 16.7 0.37 11.2 2.2 3.2 3 0 0 3 3 3 0 Molybdate transporter of MFS superfamily TANGO2 PF05742.12 AAS53676.1 - 3.5e-55 187.8 0.0 4e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Transport and Golgi organisation 2 SAMP PF05924.11 AAS53676.1 - 0.039 13.2 0.0 0.099 12.0 0.0 1.7 1 0 0 1 1 1 0 SAMP Motif LIDHydrolase PF10230.9 AAS53677.1 - 6.8e-78 261.9 0.1 7.9e-78 261.7 0.1 1.0 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Hydrolase_4 PF12146.8 AAS53677.1 - 0.0049 16.2 0.0 0.0086 15.4 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 PGAP1 PF07819.13 AAS53677.1 - 0.0052 16.5 0.1 0.012 15.4 0.0 1.6 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 AAS53677.1 - 0.0091 16.6 0.0 0.012 16.2 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Lipase_3 PF01764.25 AAS53677.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.5 1 0 0 1 1 1 0 Lipase (class 3) Thioesterase PF00975.20 AAS53677.1 - 0.08 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Utp8 PF10395.9 AAS53678.1 - 2.5e-217 723.7 0.5 3.2e-217 723.3 0.5 1.1 1 0 0 1 1 1 1 Utp8 family SYF2 PF08231.12 AAS53679.1 - 2.5e-06 28.0 13.8 4.2e-06 27.3 7.1 2.8 1 1 0 2 2 2 1 SYF2 splicing factor BAR_2 PF10455.9 AAS53680.1 - 2.6e-108 361.6 9.8 2.6e-108 361.6 9.8 1.5 2 0 0 2 2 2 1 Bin/amphiphysin/Rvs domain for vesicular trafficking BAR PF03114.18 AAS53680.1 - 2.4e-09 37.2 12.7 2.5e-07 30.6 8.2 3.2 2 1 1 3 3 3 2 BAR domain DUF4197 PF13852.6 AAS53680.1 - 0.00044 20.0 0.1 0.0014 18.4 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4197) Fea1 PF07692.11 AAS53680.1 - 0.026 13.6 0.1 0.039 13.0 0.1 1.3 1 0 0 1 1 1 0 Low iron-inducible periplasmic protein PP2C_C PF07830.13 AAS53680.1 - 0.12 12.9 0.2 0.12 12.9 0.2 2.9 2 1 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain DUF3597 PF12200.8 AAS53680.1 - 2 8.9 5.8 0.56 10.8 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3597) DUF1664 PF07889.12 AAS53680.1 - 4.2 7.4 8.5 1.8 8.6 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CdvA PF18822.1 AAS53681.2 - 0.00025 20.9 0.7 0.00025 20.9 0.7 3.9 2 1 0 4 4 4 1 CdvA-like coiled-coil domain DUF5082 PF16888.5 AAS53681.2 - 0.12 12.7 31.3 1.5 9.1 11.0 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF5082) Baculo_PEP_C PF04513.12 AAS53681.2 - 2 8.4 18.7 1.7 8.7 0.4 3.3 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Acyl-CoA_dh_2 PF08028.11 AAS53681.2 - 2.8 8.2 10.8 13 6.0 2.3 3.1 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, C-terminal domain MARVEL PF01284.23 AAS53683.1 - 4.8e-29 101.2 13.2 6e-29 100.9 13.2 1.1 1 0 0 1 1 1 1 Membrane-associating domain Band_7 PF01145.25 AAS53684.1 - 3.9e-24 85.6 6.1 6.4e-24 84.9 5.9 1.4 1 1 0 1 1 1 1 SPFH domain / Band 7 family UQ_con PF00179.26 AAS53685.1 - 1.6e-37 128.3 0.0 1.7e-37 128.2 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme UEV PF05743.13 AAS53685.1 - 0.0033 17.3 0.1 0.0053 16.6 0.1 1.4 1 0 0 1 1 1 1 UEV domain UFC1 PF08694.11 AAS53685.1 - 0.024 14.3 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 RWD PF05773.22 AAS53685.1 - 0.041 14.2 0.1 0.045 14.0 0.1 1.3 1 0 0 1 1 1 0 RWD domain Prok-E2_B PF14461.6 AAS53685.1 - 0.052 13.3 0.0 0.071 12.8 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Pet20 PF08692.10 AAS53686.1 - 1e-10 42.4 0.0 1e-10 42.4 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial protein Pet20 WW PF00397.26 AAS53688.1 - 9e-10 38.5 4.3 2e-09 37.4 4.3 1.6 1 0 0 1 1 1 1 WW domain FF PF01846.19 AAS53688.1 - 0.00017 21.7 1.4 0.00072 19.7 0.1 2.8 3 0 0 3 3 3 1 FF domain Glyco_hyd_101C PF17451.2 AAS53688.1 - 0.072 13.4 0.4 0.32 11.3 0.4 1.9 2 0 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Proteasome PF00227.26 AAS53689.1 - 2.4e-58 196.8 0.3 3.1e-58 196.4 0.3 1.1 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS53689.1 - 4.1e-12 45.5 0.9 8.1e-12 44.6 0.2 1.9 2 0 0 2 2 2 1 Proteasome subunit A N-terminal signature RuvA_C PF07499.13 AAS53689.1 - 0.012 16.0 0.2 0.064 13.7 0.0 2.3 2 0 0 2 2 2 0 RuvA, C-terminal domain Tmemb_170 PF10190.9 AAS53690.1 - 2.2e-12 47.3 10.1 2.7e-12 47.0 10.1 1.1 1 0 0 1 1 1 1 Putative transmembrane protein 170 SH3_1 PF00018.28 AAS53691.1 - 2.1e-16 59.3 0.0 3.1e-16 58.7 0.0 1.3 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS53691.1 - 3.9e-11 42.6 0.0 8.2e-11 41.6 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS53691.1 - 6.4e-11 41.8 0.0 9.3e-11 41.3 0.0 1.2 1 0 0 1 1 1 1 Variant SH3 domain NCA2 PF08637.10 AAS53692.1 - 1.3e-93 313.3 0.0 1.9e-93 312.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 HTH_26 PF13443.6 AAS53692.1 - 0.032 14.7 0.0 0.13 12.8 0.0 2.1 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain MFS_1 PF07690.16 AAS53693.1 - 1.6e-35 122.7 29.6 1.6e-35 122.7 29.6 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS53693.1 - 4.8e-13 48.8 21.4 7.2e-13 48.2 21.4 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter NDC10_II PF16787.5 AAS53694.1 - 4.7e-58 196.7 5.4 4.1e-56 190.4 5.4 2.2 1 1 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit, domain 2 GCR1_C PF12550.8 AAS53694.1 - 1.1e-19 70.5 0.0 2.4e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Vps62 PF06101.11 AAS53695.1 - 1.4e-06 26.9 2.4 3.7e-06 25.5 2.4 1.7 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 ABC2_membrane PF01061.24 AAS53697.2 - 1.5e-45 155.2 49.0 1.3e-26 93.3 16.3 2.5 3 0 0 3 3 3 2 ABC-2 type transporter PDR_CDR PF06422.12 AAS53697.2 - 3.3e-22 78.2 4.5 3.4e-18 65.3 0.4 2.9 2 0 0 2 2 2 2 CDR ABC transporter ABC_tran PF00005.27 AAS53697.2 - 6.3e-22 78.6 0.0 5.8e-10 39.8 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_16 PF13191.6 AAS53697.2 - 0.001 19.5 0.0 0.0024 18.3 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC2_membrane_3 PF12698.7 AAS53697.2 - 0.0081 15.3 41.1 0.052 12.6 18.6 2.3 2 0 0 2 2 2 2 ABC-2 family transporter protein Dynamin_N PF00350.23 AAS53697.2 - 0.077 13.1 0.1 0.16 12.0 0.1 1.5 1 0 0 1 1 1 0 Dynamin family SART-1 PF03343.13 AAS53698.1 - 3.1e-36 125.2 35.9 2e-35 122.5 35.9 2.3 1 1 0 1 1 1 1 SART-1 family Nop PF01798.18 AAS53699.2 - 2.6e-82 275.8 0.3 2.6e-82 275.8 0.3 2.6 3 0 0 3 3 3 1 snoRNA binding domain, fibrillarin NOP5NT PF08156.13 AAS53699.2 - 8.9e-19 67.7 3.7 8.9e-19 67.7 3.7 2.5 2 1 0 2 2 2 1 NOP5NT (NUC127) domain CTP_transf_1 PF01148.20 AAS53700.1 - 1.2e-06 28.5 3.4 1.9e-06 27.9 3.4 1.3 1 0 0 1 1 1 1 Cytidylyltransferase family Ribosomal_L18A PF01775.17 AAS53701.3 - 7.7e-54 181.0 0.9 1e-53 180.6 0.9 1.1 1 0 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A MMS1_N PF10433.9 AAS53702.1 - 0.021 13.5 0.2 0.13 10.8 0.2 2.0 1 1 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term SLD5_C PF16922.5 AAS53703.2 - 7.2e-20 70.9 0.1 1.2e-19 70.2 0.1 1.4 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 AAS53703.2 - 1.3e-08 35.3 0.1 4e-08 33.7 0.1 1.8 1 1 0 1 1 1 1 GINS complex protein MFS_1 PF07690.16 AAS53704.1 - 2.5e-29 102.3 21.0 4e-29 101.6 21.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS53704.1 - 5.3e-22 78.3 20.9 1.1e-21 77.2 20.9 1.4 1 1 0 1 1 1 1 Sugar (and other) transporter DUF2231 PF09990.9 AAS53704.1 - 0.21 12.0 2.8 0.31 11.5 0.1 2.7 2 2 0 2 2 2 0 Predicted membrane protein (DUF2231) Transgly_assoc PF04226.13 AAS53704.1 - 3.9 7.8 9.7 8.9 6.7 4.5 3.0 2 0 0 2 2 2 0 Transglycosylase associated protein Peptidase_M16_C PF05193.21 AAS53705.1 - 5.1e-17 62.5 0.0 1.3e-15 57.9 0.0 2.3 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 AAS53705.1 - 3.8e-09 36.7 0.0 1.2e-08 35.1 0.0 1.8 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Pkinase PF00069.25 AAS53706.1 - 3.3e-63 213.5 0.1 4.7e-63 213.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53706.1 - 1.6e-32 112.8 0.0 2.6e-32 112.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 AAS53706.1 - 1.5e-06 27.7 0.0 2.8e-06 26.8 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AAS53706.1 - 6.2e-06 25.7 0.0 1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 AAS53706.1 - 4.2e-05 23.3 0.3 0.022 14.4 0.0 2.3 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AAS53706.1 - 0.0021 16.9 0.0 0.0021 16.9 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 AAS53706.1 - 0.0036 16.3 0.1 0.0077 15.2 0.1 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 AAS53706.1 - 0.058 12.5 0.0 0.099 11.7 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 AAS53706.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Peptidase_M4 PF01447.18 AAS53707.1 - 0.022 15.3 0.6 0.05 14.1 0.1 1.7 2 0 0 2 2 2 0 Thermolysin metallopeptidase, catalytic domain HlyIII PF03006.20 AAS53708.1 - 1.1e-53 182.2 16.3 1.4e-53 181.9 16.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF3493 PF11998.8 AAS53708.1 - 0.041 14.0 1.0 0.13 12.4 1.0 1.8 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 TssN PF17555.2 AAS53708.1 - 2.6 7.4 10.7 0.19 11.1 4.6 1.9 1 1 1 2 2 2 0 Type VI secretion system, TssN Phage_holin_3_7 PF05449.11 AAS53708.1 - 5.6 7.1 7.1 1.5 8.9 1.6 2.5 2 0 0 2 2 2 0 Putative 3TM holin, Phage_holin_3 Ribosomal_L22e PF01776.17 AAS53709.1 - 0.15 12.4 0.0 0.24 11.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal L22e protein family PTS_2-RNA PF01885.16 AAS53710.1 - 3.7e-56 190.0 0.0 4.5e-56 189.8 0.0 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family OapA PF04225.12 AAS53710.1 - 0.021 14.9 0.0 0.062 13.4 0.0 1.9 1 1 0 1 1 1 0 Opacity-associated protein A LysM-like domain La PF05383.17 AAS53710.1 - 0.088 12.9 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 La domain Vps39_2 PF10367.9 AAS53712.1 - 0.0033 17.9 0.6 0.0089 16.5 0.1 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 CPL PF08144.11 AAS53713.1 - 2.1e-47 161.1 7.5 1.4e-44 151.9 0.0 5.3 5 2 1 7 7 7 2 CPL (NUC119) domain PUF PF00806.19 AAS53713.1 - 1.4e-07 30.8 3.7 12 5.8 0.0 7.0 7 0 0 7 7 7 3 Pumilio-family RNA binding repeat SAC3 PF12209.8 AAS53713.1 - 0.0029 17.7 2.6 0.85 9.8 0.0 4.1 3 1 0 3 3 3 1 Leucine permease transcriptional regulator helical domain DUF4253 PF14062.6 AAS53713.1 - 0.021 15.0 0.0 0.07 13.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) CDC45 PF02724.14 AAS53713.1 - 5.8 5.1 12.0 2 6.6 9.0 1.6 2 0 0 2 2 2 0 CDC45-like protein Sugar_tr PF00083.24 AAS53714.1 - 4.3e-122 408.2 28.7 5e-122 408.0 28.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53714.1 - 4.2e-28 98.3 36.9 2.7e-27 95.6 30.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_3 PF05977.13 AAS53714.1 - 0.0047 15.4 0.9 0.0047 15.4 0.9 2.1 2 0 0 2 2 2 1 Transmembrane secretion effector TMEM237 PF15383.6 AAS53714.1 - 0.02 14.0 0.2 0.05 12.7 0.2 1.6 1 0 0 1 1 1 0 Transmembrane protein 237 Phage_holin_3_2 PF04550.12 AAS53714.1 - 1.2 9.7 5.8 15 6.2 0.1 3.2 2 1 0 2 2 2 0 Phage holin family 2 Sec20 PF03908.13 AAS53715.1 - 5.7e-22 77.4 0.1 9.3e-22 76.8 0.1 1.3 1 0 0 1 1 1 1 Sec20 ERG4_ERG24 PF01222.17 AAS53717.2 - 2.6e-166 553.7 10.1 2.9e-166 553.5 10.1 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 AAS53717.2 - 1.7e-05 24.4 0.7 4.1e-05 23.2 0.3 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) Aha1_N PF09229.11 AAS53718.1 - 2.8e-27 95.6 0.0 3.5e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal CEP19 PF14933.6 AAS53718.1 - 0.16 12.3 0.0 0.24 11.7 0.0 1.3 1 0 0 1 1 1 0 CEP19-like protein RNase_P_pop3 PF08228.11 AAS53719.1 - 7.4e-66 221.1 0.0 8.7e-66 220.8 0.0 1.0 1 0 0 1 1 1 1 RNase P subunit Pop3 WSC PF01822.19 AAS53720.1 - 5.9e-06 26.4 7.6 5.9e-06 26.4 7.6 2.5 2 1 0 2 2 2 1 WSC domain Endomucin PF07010.12 AAS53720.1 - 0.28 11.1 34.4 0.031 14.3 29.8 1.6 2 0 0 2 2 2 0 Endomucin DUF5305 PF17231.2 AAS53720.1 - 1.6 8.1 6.0 5.3 6.4 6.0 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5305) GREB1 PF15782.5 AAS53720.1 - 7.7 3.5 12.7 10 3.1 12.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Vps55 PF04133.14 AAS53722.1 - 1.2e-39 134.8 6.1 1.4e-39 134.6 6.1 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 55 DUF4133 PF13571.6 AAS53722.1 - 1.7 9.1 6.4 7.7 6.9 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) HSP70 PF00012.20 AAS53723.2 - 8.4e-266 882.9 15.7 9.6e-266 882.7 15.7 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS53723.2 - 1.1e-14 54.0 3.3 1.8e-12 46.8 1.3 2.3 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AAS53723.2 - 0.00023 20.9 0.1 0.0007 19.4 0.1 1.9 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain FtsA PF14450.6 AAS53723.2 - 0.0054 17.1 8.0 0.58 10.6 0.4 4.2 3 2 0 3 3 3 2 Cell division protein FtsA CDT1_C PF16679.5 AAS53724.2 - 6.4e-07 29.7 0.4 1.6e-06 28.5 0.1 1.9 2 0 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain CDT1 PF08839.11 AAS53724.2 - 0.011 16.0 0.0 0.027 14.8 0.0 1.6 1 0 0 1 1 1 0 DNA replication factor CDT1 like Hydrolase PF00702.26 AAS53725.1 - 3.7e-17 63.3 0.0 3.3e-10 40.6 0.0 2.6 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 AAS53725.1 - 4.2e-16 59.0 0.1 1.1e-15 57.6 0.1 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase PF13246.6 AAS53725.1 - 1.8e-05 24.7 0.0 3.7e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 AAS53725.1 - 0.004 16.9 0.1 0.025 14.3 0.0 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AAS53725.1 - 0.053 13.1 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase MCM PF00493.23 AAS53726.2 - 1.1e-96 322.3 0.6 1.6e-96 321.8 0.6 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AAS53726.2 - 4.9e-32 110.4 0.0 1e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AAS53726.2 - 1.3e-24 86.4 1.0 2.8e-24 85.4 1.0 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 AAS53726.2 - 1.2e-07 31.3 0.3 1.8e-06 27.5 0.0 2.7 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 AAS53726.2 - 4.1e-05 24.1 0.0 0.00055 20.5 0.0 2.6 2 0 0 2 2 2 1 MCM N-terminal domain AAA_3 PF07726.11 AAS53726.2 - 0.0027 17.6 0.0 0.005 16.7 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AAS53726.2 - 0.0071 16.1 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_5 PF07728.14 AAS53726.2 - 0.13 12.2 0.0 0.41 10.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) eIF-5a PF01287.20 AAS53727.1 - 1.2e-29 102.2 0.5 1.7e-29 101.7 0.5 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.12 AAS53727.1 - 0.003 17.6 0.0 0.0049 16.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor P (EF-P) KOW-like domain Anp1 PF03452.14 AAS53728.1 - 1.7e-109 365.3 0.0 2.3e-109 364.9 0.0 1.2 1 0 0 1 1 1 1 Anp1 UBA PF00627.31 AAS53729.1 - 6.7e-25 86.6 2.9 2.5e-15 56.0 0.5 2.4 2 0 0 2 2 2 2 UBA/TS-N domain ubiquitin PF00240.23 AAS53729.1 - 6.5e-14 51.4 0.1 2e-13 49.9 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin family XPC-binding PF09280.11 AAS53729.1 - 3.8e-11 42.5 0.7 7.6e-11 41.6 0.7 1.5 1 0 0 1 1 1 1 XPC-binding domain Rad60-SLD PF11976.8 AAS53729.1 - 5.4e-06 26.1 0.8 1.5e-05 24.7 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 AAS53729.1 - 0.00035 20.6 0.0 0.00082 19.5 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 AAS53729.1 - 0.00059 20.4 0.0 0.0012 19.4 0.0 1.5 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_5 PF18037.1 AAS53729.1 - 0.0021 18.4 0.1 0.0036 17.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-like domain P30 PF07390.11 AAS53729.1 - 0.012 15.7 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 Mycoplasma P30 protein CUE PF02845.16 AAS53729.1 - 0.036 13.8 1.5 1.5 8.6 0.0 3.7 4 1 0 4 4 4 0 CUE domain Cytochrom_C PF00034.21 AAS53731.1 - 5.3e-09 37.1 0.2 1.2e-08 35.9 0.2 1.6 1 1 0 1 1 1 1 Cytochrome c Cytochrome_CBB3 PF13442.6 AAS53731.1 - 7.3e-07 29.4 1.7 6.3e-06 26.4 1.7 2.1 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C550 PF14495.6 AAS53731.1 - 0.36 10.5 2.1 1.9 8.2 2.1 2.1 1 1 0 1 1 1 0 Cytochrome c-550 domain NAD_kinase PF01513.21 AAS53732.2 - 2.1e-86 289.8 0.0 4e-86 288.8 0.0 1.5 2 0 0 2 2 2 1 ATP-NAD kinase DAGK_cat PF00781.24 AAS53732.2 - 0.0095 15.6 0.0 0.02 14.5 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain TAL_FSA PF00923.19 AAS53732.2 - 0.11 11.9 0.2 0.18 11.1 0.2 1.3 1 0 0 1 1 1 0 Transaldolase/Fructose-6-phosphate aldolase DUF2846 PF11008.8 AAS53732.2 - 0.18 11.8 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2846) GPR15L PF15854.5 AAS53732.2 - 0.27 11.5 2.3 1.4 9.2 0.3 2.5 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 GDA1_CD39 PF01150.17 AAS53733.1 - 1.2e-113 380.0 0.0 1.5e-113 379.7 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family Ppx-GppA PF02541.16 AAS53733.1 - 0.031 13.7 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 Ppx/GppA phosphatase family Isy1 PF06246.12 AAS53734.1 - 1.9e-56 191.5 13.7 1e-54 185.8 13.7 2.0 1 1 0 1 1 1 1 Isy1-like splicing family DivIC PF04977.15 AAS53734.1 - 0.0064 16.2 8.6 0.67 9.8 5.6 2.6 2 0 0 2 2 2 2 Septum formation initiator Androgen_recep PF02166.16 AAS53734.1 - 0.3 9.9 3.1 0.38 9.5 3.1 1.1 1 0 0 1 1 1 0 Androgen receptor CNDH2_C PF16858.5 AAS53734.1 - 0.92 9.3 9.5 14 5.5 9.4 2.2 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF5082 PF16888.5 AAS53735.1 - 0.0095 16.2 2.5 0.0095 16.2 2.5 3.7 2 1 2 4 4 4 1 Domain of unknown function (DUF5082) JIP_LZII PF16471.5 AAS53735.1 - 0.054 13.7 6.6 0.69 10.1 0.8 2.8 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DHR10 PF18595.1 AAS53735.1 - 0.3 11.2 21.6 0.068 13.2 2.6 3.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Prefoldin PF02996.17 AAS53735.1 - 1.5 8.7 8.8 1 9.3 0.3 3.1 3 1 0 3 3 3 0 Prefoldin subunit DUF1664 PF07889.12 AAS53735.1 - 4.7 7.3 17.9 0.58 10.2 4.8 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DivIVA PF05103.13 AAS53735.1 - 5.2 7.2 9.8 0.88 9.7 0.6 2.6 1 1 1 2 2 2 0 DivIVA protein DUF2570 PF10828.8 AAS53735.1 - 8.3 6.3 8.3 8.5 6.2 6.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) YL1_C PF08265.11 AAS53736.1 - 3.2e-14 52.4 0.5 2e-13 49.8 0.1 2.1 2 0 0 2 2 2 1 YL1 nuclear protein C-terminal domain Beta_elim_lyase PF01212.21 AAS53737.2 - 7.2e-81 271.7 0.0 8.7e-81 271.4 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AAS53737.2 - 4.7e-06 26.0 0.0 6.8e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II FAD_binding_2 PF00890.24 AAS53738.1 - 2.2e-80 270.8 2.3 2.5e-80 270.6 2.3 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 AAS53738.1 - 1e-08 35.2 2.0 2.3e-06 27.4 1.8 2.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AAS53738.1 - 2e-05 24.7 0.9 0.0001 22.4 0.6 2.3 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.22 AAS53738.1 - 6.4e-05 22.2 2.7 0.0013 17.9 1.0 2.7 3 0 0 3 3 3 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 AAS53738.1 - 0.00012 21.5 0.3 0.00025 20.4 0.3 1.5 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 AAS53738.1 - 0.0002 20.7 2.7 0.0012 18.1 1.3 2.4 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS53738.1 - 0.0004 19.7 3.6 0.031 13.5 0.7 2.4 2 0 0 2 2 2 2 Thi4 family FAD_oxidored PF12831.7 AAS53738.1 - 0.053 12.9 4.0 0.077 12.3 4.0 1.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AAS53738.1 - 0.068 12.2 1.2 3.1 6.8 1.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_9 PF13454.6 AAS53738.1 - 0.089 12.8 0.5 8.1 6.4 0.4 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 AAS53738.1 - 0.54 8.9 8.6 0.66 8.6 1.8 2.9 3 0 0 3 3 3 0 HI0933-like protein SUR7 PF06687.12 AAS53739.1 - 8.7e-36 123.5 10.7 1.1e-35 123.2 10.7 1.1 1 0 0 1 1 1 1 SUR7/PalI family TMEM208_SND2 PF05620.11 AAS53739.1 - 0.94 9.2 4.8 0.29 10.9 1.3 1.9 2 1 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Thymidylate_kin PF02223.17 AAS53740.1 - 2e-39 135.2 0.0 2.3e-39 135.0 0.0 1.1 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 AAS53740.1 - 0.0012 19.1 2.8 0.0024 18.2 2.8 1.6 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS53740.1 - 0.013 15.9 0.6 0.02 15.3 0.6 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 AAS53740.1 - 0.044 13.9 0.0 0.18 12.0 0.0 1.8 1 1 0 2 2 2 0 AAA domain FAD_binding_4 PF01565.23 AAS53740.1 - 0.054 13.2 0.1 1.7 8.4 0.1 2.3 2 0 0 2 2 2 0 FAD binding domain AAA_18 PF13238.6 AAS53740.1 - 0.12 12.9 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Clat_adaptor_s PF01217.20 AAS53741.1 - 2.2e-48 163.8 0.3 2.5e-48 163.6 0.3 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain RTP1_C1 PF10363.9 AAS53741.1 - 0.018 15.3 0.1 0.027 14.6 0.1 1.5 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 AAA PF00004.29 AAS53742.2 - 1.1e-53 181.2 0.0 4.8e-43 146.8 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) PEX-1N PF09262.11 AAS53742.2 - 3.1e-24 85.2 0.1 1.1e-23 83.5 0.0 2.0 2 0 0 2 2 1 1 Peroxisome biogenesis factor 1, N-terminal AAA_lid_3 PF17862.1 AAS53742.2 - 3.8e-15 55.4 0.5 2e-09 37.1 0.1 2.5 2 0 0 2 2 2 2 AAA+ lid domain AAA_16 PF13191.6 AAS53742.2 - 2.1e-12 47.7 1.5 0.00023 21.6 0.1 4.4 2 2 2 4 4 4 2 AAA ATPase domain AAA_22 PF13401.6 AAS53742.2 - 2.1e-09 37.8 0.4 0.0008 19.7 0.0 4.1 3 2 1 4 4 3 2 AAA domain AAA_24 PF13479.6 AAS53742.2 - 3.8e-08 33.3 0.0 4.9e-05 23.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AAS53742.2 - 7.6e-07 29.2 0.3 0.017 15.0 0.0 3.2 4 0 0 4 4 3 2 NACHT domain AAA_33 PF13671.6 AAS53742.2 - 1.6e-06 28.4 0.0 0.003 17.7 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_2 PF07724.14 AAS53742.2 - 1.6e-06 28.3 0.0 0.00096 19.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 AAS53742.2 - 2e-06 27.7 0.0 0.02 14.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_5 PF07728.14 AAS53742.2 - 3.1e-05 24.0 0.0 0.045 13.7 0.0 3.0 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AAS53742.2 - 3.8e-05 23.7 0.0 0.13 12.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain RuvB_N PF05496.12 AAS53742.2 - 5.4e-05 23.0 0.0 0.0024 17.6 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 AAS53742.2 - 0.00017 21.6 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AAS53742.2 - 0.00059 20.4 0.0 0.084 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_25 PF13481.6 AAS53742.2 - 0.00092 18.8 0.2 0.21 11.2 0.0 3.8 3 1 1 4 4 4 1 AAA domain ATPase_2 PF01637.18 AAS53742.2 - 0.0012 18.8 0.0 0.36 10.7 0.0 2.7 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AAS53742.2 - 0.0013 19.1 0.0 0.71 10.3 0.0 2.5 2 0 0 2 2 2 1 RNA helicase Mg_chelatase PF01078.21 AAS53742.2 - 0.0013 18.1 0.1 0.15 11.4 0.1 2.5 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AAS53742.2 - 0.0013 19.0 0.0 0.37 11.0 0.0 2.9 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 AAS53742.2 - 0.0052 17.3 0.0 9.8 6.7 0.0 3.2 2 1 1 3 3 3 0 ABC transporter NB-ARC PF00931.22 AAS53742.2 - 0.012 14.9 0.0 3.2 6.9 0.0 2.2 2 0 0 2 2 2 0 NB-ARC domain Sigma54_activat PF00158.26 AAS53742.2 - 0.021 14.5 0.1 9.6 5.9 0.0 2.8 2 1 0 2 2 2 0 Sigma-54 interaction domain Viral_helicase1 PF01443.18 AAS53742.2 - 0.04 13.6 0.0 0.34 10.6 0.0 2.1 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase TniB PF05621.11 AAS53742.2 - 0.042 13.3 0.0 5.8 6.3 0.0 2.8 3 0 0 3 3 3 0 Bacterial TniB protein TIP49 PF06068.13 AAS53742.2 - 0.048 12.9 0.0 0.11 11.7 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Bac_DnaA PF00308.18 AAS53742.2 - 0.05 13.4 0.0 3.6 7.4 0.0 2.4 2 0 0 2 2 2 0 Bacterial dnaA protein PEX-2N PF09263.10 AAS53742.2 - 0.073 13.4 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Peroxisome biogenesis factor 1, N-terminal AAA_30 PF13604.6 AAS53742.2 - 0.091 12.5 0.0 3.4 7.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AAS53742.2 - 0.11 12.4 0.1 0.39 10.6 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_17 PF13207.6 AAS53742.2 - 0.12 12.8 0.0 0.62 10.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_3 PF07726.11 AAS53742.2 - 0.13 12.1 0.0 0.41 10.5 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Cytidylate_kin2 PF13189.6 AAS53742.2 - 0.15 12.1 0.0 0.67 10.1 0.0 2.0 2 0 0 2 2 2 0 Cytidylate kinase-like family AAA_7 PF12775.7 AAS53742.2 - 0.16 11.4 0.0 10 5.6 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region Pkinase PF00069.25 AAS53743.1 - 8.2e-39 133.6 0.0 1.1e-38 133.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53743.1 - 2.6e-11 43.3 0.0 6.6e-11 42.0 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53743.1 - 0.00017 21.0 0.0 0.00042 19.7 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 AAS53743.1 - 0.0004 19.8 0.1 0.00069 19.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 AAS53743.1 - 0.00054 19.7 0.3 0.26 10.9 0.0 2.4 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Mito_carr PF00153.27 AAS53744.1 - 3.2e-11 43.0 0.0 0.002 18.0 0.0 3.6 3 1 0 3 3 3 3 Mitochondrial carrier protein Dpy-30 PF05186.13 AAS53745.1 - 3.8e-14 52.1 0.0 4.8e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 Dpy-30 motif Atg14 PF10186.9 AAS53746.1 - 0.0056 15.8 0.3 0.0065 15.6 0.3 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 MPS2 PF17060.5 AAS53746.1 - 0.015 14.6 0.3 0.029 13.6 0.2 1.5 1 1 1 2 2 2 0 Monopolar spindle protein 2 SNARE PF05739.19 AAS53746.1 - 0.028 14.4 0.6 0.056 13.4 0.1 1.8 2 0 0 2 2 2 0 SNARE domain DUF1664 PF07889.12 AAS53746.1 - 0.035 14.2 1.2 1.6 8.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 AAS53746.1 - 0.046 13.6 0.6 1 9.1 0.1 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 VBS PF08913.10 AAS53746.1 - 0.063 13.7 0.1 0.094 13.2 0.1 1.3 1 0 0 1 1 1 0 Vinculin Binding Site Syntaxin-6_N PF09177.11 AAS53746.1 - 0.068 13.7 5.6 1.2 9.8 1.7 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Noelin-1 PF12308.8 AAS53746.1 - 0.11 12.5 1.4 1.7 8.6 0.2 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein Sec20 PF03908.13 AAS53746.1 - 0.13 12.2 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Sec20 YlqD PF11068.8 AAS53746.1 - 0.15 12.4 3.0 0.95 9.8 0.5 2.4 2 1 0 2 2 2 0 YlqD protein ABC_tran_CTD PF16326.5 AAS53746.1 - 4 7.7 8.6 1.4 9.3 2.0 2.7 2 1 0 2 2 2 0 ABC transporter C-terminal domain DAO PF01266.24 AAS53747.1 - 7.1e-82 275.8 0.1 8.6e-82 275.5 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 AAS53747.1 - 6.2e-07 29.6 0.1 1.6e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AAS53747.1 - 0.00011 21.5 0.0 0.008 15.4 0.1 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS53747.1 - 0.0012 18.1 0.2 0.0021 17.4 0.2 1.3 1 0 0 1 1 1 1 Thi4 family MCRA PF06100.11 AAS53747.1 - 0.0019 17.1 0.1 0.0027 16.6 0.1 1.2 1 0 0 1 1 1 1 MCRA family Sacchrp_dh_NADP PF03435.18 AAS53747.1 - 0.0029 17.9 0.2 0.0058 16.9 0.2 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_9 PF13454.6 AAS53747.1 - 0.0036 17.3 0.1 0.012 15.6 0.1 1.8 2 0 0 2 2 2 1 FAD-NAD(P)-binding Pyr_redox PF00070.27 AAS53747.1 - 0.012 16.2 0.3 0.032 14.8 0.3 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 AAS53747.1 - 0.017 14.0 0.3 0.028 13.3 0.3 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pkinase PF00069.25 AAS53748.1 - 2.9e-68 230.1 0.0 4.2e-68 229.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS53748.1 - 8.2e-34 117.1 0.0 1.2e-33 116.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS53748.1 - 1.8e-10 40.6 0.0 3.1e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AAS53748.1 - 0.00031 20.1 0.0 0.00057 19.3 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS53748.1 - 0.0013 18.7 0.1 0.015 15.2 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS53748.1 - 0.0071 15.3 2.6 0.0086 15.1 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain RIO1 PF01163.22 AAS53748.1 - 0.011 15.3 0.1 0.084 12.5 0.0 2.3 2 1 0 3 3 3 0 RIO1 family Sld3_N PF18523.1 AAS53748.1 - 0.012 15.7 0.1 0.045 13.9 0.1 2.0 1 0 0 1 1 1 0 Sld3 N-terminal domain Pkinase_fungal PF17667.1 AAS53748.1 - 0.027 13.3 0.0 0.057 12.2 0.0 1.5 1 0 0 1 1 1 0 Fungal protein kinase KCH PF16944.5 AAS53749.2 - 1.8e-81 273.6 11.5 2.3e-81 273.3 11.5 1.1 1 0 0 1 1 1 1 Fungal potassium channel Innexin PF00876.18 AAS53749.2 - 0.0026 17.1 0.0 0.0052 16.1 0.0 1.4 1 0 0 1 1 1 1 Innexin DUF573 PF04504.14 AAS53749.2 - 0.21 12.3 0.9 0.56 10.9 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF573 Gsf2 PF11055.8 AAS53752.1 - 2.4e-174 579.5 0.0 2.8e-174 579.2 0.0 1.0 1 0 0 1 1 1 1 Glucose signalling factor 2 MMS1_N PF10433.9 AAS53753.2 - 1.3e-75 254.9 0.0 2.3e-75 254.1 0.0 1.4 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 AAS53753.2 - 1.1e-52 179.4 0.0 6.3e-51 173.6 0.0 3.2 3 1 0 3 3 3 1 CPSF A subunit region Suc_Fer-like PF06999.12 AAS53754.1 - 2.3e-31 109.2 0.0 2.8e-31 108.9 0.0 1.1 1 0 0 1 1 1 1 Sucrase/ferredoxin-like Hit1_C PF18268.1 AAS53755.1 - 7e-42 141.5 0.4 9.7e-42 141.0 0.4 1.2 1 0 0 1 1 1 1 Hit1 C-terminal zf-HIT PF04438.16 AAS53755.1 - 2.3e-10 40.2 13.4 4.1e-10 39.3 13.4 1.4 1 0 0 1 1 1 1 HIT zinc finger YL1_C PF08265.11 AAS53755.1 - 0.014 15.2 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 YL1 nuclear protein C-terminal domain zf-MYND PF01753.18 AAS53755.1 - 0.1 12.7 12.0 0.17 12.0 12.0 1.4 1 0 0 1 1 1 0 MYND finger zf-Mss51 PF13824.6 AAS53755.1 - 0.15 12.2 5.9 0.37 10.9 5.9 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C6H2 PF15801.5 AAS53755.1 - 0.17 12.2 7.6 0.35 11.2 7.6 1.5 1 0 0 1 1 1 0 zf-MYND-like zinc finger, mRNA-binding PolC_DP2 PF03833.13 AAS53755.1 - 0.26 9.1 1.5 0.29 9.0 1.5 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 C1_2 PF03107.16 AAS53755.1 - 1.4 9.3 8.7 3.2 8.2 8.7 1.7 1 0 0 1 1 1 0 C1 domain Sedlin_N PF04628.13 AAS53756.1 - 3.4e-06 27.2 0.0 4.6e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region DUF676 PF05057.14 AAS53757.1 - 8.5e-43 146.4 0.0 1.4e-42 145.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 AAS53757.1 - 3.1e-06 27.2 0.1 4.9e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase PGAP1 PF07819.13 AAS53757.1 - 0.00032 20.5 0.4 0.00081 19.2 0.1 1.8 2 0 0 2 2 2 1 PGAP1-like protein Abhydrolase_6 PF12697.7 AAS53757.1 - 0.013 16.1 0.0 0.017 15.7 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family Cutinase PF01083.22 AAS53757.1 - 0.03 14.3 0.1 0.25 11.3 0.0 2.2 2 0 0 2 2 2 0 Cutinase TraP PF07296.11 AAS53757.1 - 0.069 12.3 0.1 0.11 11.6 0.1 1.3 1 0 0 1 1 1 0 TraP protein Lipase_3 PF01764.25 AAS53757.1 - 0.1 12.5 0.0 0.23 11.3 0.0 1.6 1 0 0 1 1 1 0 Lipase (class 3) TPK_catalytic PF04263.16 AAS53758.1 - 1.5e-25 89.6 0.0 3e-25 88.6 0.0 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 AAS53758.1 - 2.3e-10 40.1 0.0 4.3e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain TFIID-18kDa PF02269.16 AAS53759.1 - 1.2e-35 121.4 0.3 1.3e-34 118.1 0.2 2.2 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit Ribosomal_60s PF00428.19 AAS53759.1 - 0.0034 17.9 3.0 0.0034 17.9 3.0 1.9 2 0 0 2 2 2 1 60s Acidic ribosomal protein AAA PF00004.29 AAS53760.2 - 3.7e-06 27.4 0.1 0.00029 21.3 0.0 3.3 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AAS53760.2 - 0.025 14.5 0.3 0.93 9.4 0.0 2.7 2 1 1 3 3 3 0 Rad17 P-loop domain KH_8 PF17903.1 AAS53761.2 - 2.7e-05 24.1 0.0 5.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 AAS53761.2 - 0.068 13.0 0.2 0.16 11.8 0.2 1.6 1 0 0 1 1 1 0 KH domain Sec16_N PF12935.7 AAS53761.2 - 0.081 13.1 0.2 0.11 12.6 0.2 1.2 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 N-terminus MDM31_MDM32 PF08118.11 AAS53762.1 - 2.7e-90 303.5 9.6 2.4e-42 145.3 0.1 4.0 2 1 2 4 4 4 4 Yeast mitochondrial distribution and morphology (MDM) proteins G-patch_2 PF12656.7 AAS53763.1 - 2.2e-21 75.7 0.3 2.2e-21 75.7 0.3 2.2 2 0 0 2 2 2 1 G-patch domain She9_MDM33 PF05546.11 AAS53764.1 - 4.9e-85 284.3 11.7 4.9e-85 284.3 11.7 2.0 2 0 0 2 2 2 1 She9 / Mdm33 family ApoLp-III PF07464.11 AAS53764.1 - 0.023 14.8 8.4 0.22 11.6 0.9 2.6 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Phi-29_GP16_7 PF06720.11 AAS53764.1 - 0.13 12.1 3.0 0.14 12.0 0.7 2.2 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 LXG PF04740.12 AAS53764.1 - 0.18 11.5 11.0 0.57 9.9 1.0 2.6 3 0 0 3 3 3 0 LXG domain of WXG superfamily TMF_DNA_bd PF12329.8 AAS53764.1 - 0.2 11.7 19.5 0.14 12.1 0.4 4.3 3 1 0 4 4 4 0 TATA element modulatory factor 1 DNA binding PspA_IM30 PF04012.12 AAS53764.1 - 0.5 9.9 21.0 2.4 7.7 1.7 3.0 2 1 0 2 2 2 0 PspA/IM30 family YtxH PF12732.7 AAS53764.1 - 0.67 10.5 4.9 7 7.3 0.2 3.8 3 1 0 3 3 3 0 YtxH-like protein DUF948 PF06103.11 AAS53764.1 - 6.1 7.2 7.3 35 4.8 0.3 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 AAS53764.1 - 9 6.4 10.1 23 5.0 0.9 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) AAA PF00004.29 AAS53765.2 - 4.4e-46 156.6 0.0 1.2e-45 155.1 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Prot_ATP_ID_OB PF16450.5 AAS53765.2 - 3.8e-09 36.4 0.3 1.6e-08 34.3 0.0 2.2 2 0 0 2 2 2 1 Proteasomal ATPase OB C-terminal domain AAA_2 PF07724.14 AAS53765.2 - 3.3e-08 33.9 0.0 6.5e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AAS53765.2 - 2.2e-07 31.4 0.0 3e-05 24.5 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_5 PF07728.14 AAS53765.2 - 3.4e-07 30.3 0.1 1.4e-06 28.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AAS53765.2 - 3e-05 24.3 0.7 0.0045 17.3 0.0 2.7 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 AAS53765.2 - 7.8e-05 22.0 0.0 0.00014 21.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 AAS53765.2 - 0.00028 20.6 0.0 0.00086 19.1 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 AAS53765.2 - 0.00095 19.1 0.1 0.0033 17.4 0.0 1.9 3 0 0 3 3 2 1 NTPase AAA_lid_3 PF17862.1 AAS53765.2 - 0.0011 18.7 0.1 0.0027 17.5 0.1 1.7 1 0 0 1 1 1 1 AAA+ lid domain TsaE PF02367.17 AAS53765.2 - 0.0016 18.4 0.0 0.0033 17.4 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 AAS53765.2 - 0.0017 18.1 0.0 0.0046 16.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS53765.2 - 0.002 18.7 0.0 0.0093 16.5 0.0 2.1 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 AAS53765.2 - 0.0023 18.3 0.0 0.0045 17.4 0.0 1.5 1 0 0 1 1 1 1 RNA helicase TIP49 PF06068.13 AAS53765.2 - 0.0031 16.8 0.0 0.0058 15.9 0.0 1.4 1 1 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 AAS53765.2 - 0.0033 17.0 0.0 0.025 14.1 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_24 PF13479.6 AAS53765.2 - 0.0037 17.0 0.0 0.0066 16.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 AAS53765.2 - 0.0041 17.2 0.0 0.0089 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AAS53765.2 - 0.0045 16.8 0.0 0.013 15.4 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TniB PF05621.11 AAS53765.2 - 0.0065 15.9 0.0 0.34 10.3 0.0 2.3 2 0 0 2 2 2 1 Bacterial TniB protein AAA_33 PF13671.6 AAS53765.2 - 0.0072 16.5 0.0 0.016 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain Sigma54_activat PF00158.26 AAS53765.2 - 0.0081 15.9 0.0 0.18 11.5 0.0 2.5 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase PF01078.21 AAS53765.2 - 0.0086 15.5 0.1 0.021 14.2 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AAS53765.2 - 0.018 15.3 0.0 0.039 14.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AAS53765.2 - 0.02 14.8 0.1 0.14 12.1 0.0 2.2 1 1 1 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 AAS53765.2 - 0.028 14.1 0.0 0.065 13.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase_2 PF01637.18 AAS53765.2 - 0.037 13.9 0.1 0.47 10.3 0.0 2.4 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 AAS53765.2 - 0.04 13.7 0.1 0.092 12.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 AAS53765.2 - 0.13 12.5 0.0 0.4 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AAS53765.2 - 0.23 11.0 1.8 0.53 9.8 0.1 2.2 2 1 0 3 3 3 0 AAA domain Glyco_transf_22 PF03901.17 AAS53766.2 - 1.5e-70 238.6 13.4 1.8e-70 238.3 13.4 1.0 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Wzy_C PF04932.15 AAS53766.2 - 0.016 14.9 2.2 0.032 13.9 0.9 2.3 2 0 0 2 2 2 0 O-Antigen ligase IBN_N PF03810.19 AAS53767.1 - 2.3e-12 46.7 1.0 5.9e-12 45.3 0.3 2.2 2 0 0 2 2 2 1 Importin-beta N-terminal domain Vac14_Fab1_bd PF12755.7 AAS53767.1 - 0.0052 17.4 2.4 0.014 16.0 0.1 3.0 3 0 0 3 3 3 1 Vacuolar 14 Fab1-binding region RIX1 PF08167.12 AAS53767.1 - 0.0075 16.0 0.3 0.52 10.0 0.1 3.1 1 1 1 2 2 2 2 rRNA processing/ribosome biogenesis Urb2 PF10441.9 AAS53767.1 - 0.044 13.7 0.3 0.24 11.3 0.2 2.0 1 1 0 1 1 1 0 Urb2/Npa2 family DUF445 PF04286.12 AAS53767.1 - 0.056 13.2 0.6 2 8.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF445) CBFD_NFYB_HMF PF00808.23 AAS53768.1 - 5.3e-14 52.3 1.5 8e-14 51.7 1.5 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2795 PF11387.8 AAS53768.1 - 0.093 13.0 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2795) Hydrolase_like PF13242.6 AAS53768.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Histone PF00125.24 AAS53768.1 - 0.14 12.5 3.0 0.2 12.0 0.1 2.0 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Utp12 PF04003.12 AAS53769.2 - 4.2e-22 78.5 3.5 7.9e-22 77.6 3.5 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 AAS53769.2 - 0.041 14.2 0.0 0.37 11.1 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS53769.2 - 0.11 13.4 0.0 4.4 8.3 0.0 3.4 4 0 0 4 4 4 0 WD domain, G-beta repeat IU_nuc_hydro PF01156.19 AAS53770.1 - 1.3e-72 245.0 0.0 1.5e-72 244.7 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase p450 PF00067.22 AAS53771.1 - 1.7e-49 168.8 0.0 2.2e-49 168.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Cyclin_N PF00134.23 AAS53771.1 - 0.055 13.2 0.4 0.16 11.8 0.0 1.9 2 1 0 2 2 2 0 Cyclin, N-terminal domain DIT1_PvcA PF05141.12 AAS53772.1 - 1.2e-97 326.7 0.0 2.1e-97 325.9 0.0 1.3 1 0 0 1 1 1 1 Pyoverdine/dityrosine biosynthesis protein DUF5348 PF17295.2 AAS53772.1 - 0.041 13.8 0.7 0.66 9.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5348) SHS2_Rpb7-N PF03876.17 AAS53773.1 - 4.6e-18 65.3 0.0 8e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AAS53773.1 - 8.2e-13 48.5 0.0 1.2e-12 47.9 0.0 1.2 1 0 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 AAS53773.1 - 0.00051 20.3 0.0 0.00089 19.5 0.0 1.5 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 Ribosomal_L13 PF00572.18 AAS53774.1 - 1.2e-48 164.4 0.2 1.5e-48 164.2 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L13 GH43_C2 PF17851.1 AAS53774.1 - 0.094 12.4 0.1 0.14 11.9 0.1 1.2 1 0 0 1 1 1 0 Beta xylosidase C-terminal Concanavalin A-like domain RNA_pol_Rpb2_6 PF00562.28 AAS53775.1 - 2.4e-125 418.6 0.1 4e-125 417.9 0.1 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AAS53775.1 - 4.8e-69 231.9 0.1 8.2e-69 231.2 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_2 PF04561.14 AAS53775.1 - 1.2e-51 175.1 0.1 2.1e-51 174.3 0.1 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_7 PF04560.20 AAS53775.1 - 3.4e-34 117.1 0.1 7.5e-34 116.0 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_4 PF04566.13 AAS53775.1 - 2.6e-25 88.5 0.8 6.2e-25 87.3 0.8 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_3 PF04565.16 AAS53775.1 - 3.1e-24 84.9 1.0 6.4e-24 83.9 0.1 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 AAS53775.1 - 1.3e-19 70.5 0.7 1.3e-19 70.5 0.7 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb2, domain 5 MRNIP PF15749.5 AAS53775.1 - 0.066 13.9 0.1 0.12 13.1 0.1 1.4 1 0 0 1 1 1 0 MRN-interacting protein RNA_pol_Rpb2_45 PF10385.9 AAS53775.1 - 0.18 12.1 0.2 2.2 8.6 0.0 2.6 2 0 0 2 2 2 0 RNA polymerase beta subunit external 1 domain Ribosomal_L23 PF00276.20 AAS53776.1 - 1.3e-10 41.5 0.0 2.7e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L23 DUF2250 PF10007.9 AAS53776.1 - 0.1 12.7 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) TRAPP PF04051.16 AAS53779.1 - 2e-41 141.1 0.0 2.4e-41 140.8 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Acetyltransf_1 PF00583.25 AAS53780.2 - 6.3e-14 52.2 0.0 8.4e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 AAS53780.2 - 6.4e-07 29.3 0.0 1.1e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 AAS53780.2 - 1.1e-06 28.6 0.1 1.5e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AAS53780.2 - 1.3e-05 25.5 0.0 2.3e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AAS53780.2 - 0.0017 18.4 0.3 0.0033 17.5 0.3 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 AAS53780.2 - 0.0021 17.5 0.3 0.0028 17.2 0.3 1.3 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 AAS53780.2 - 0.13 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase S-methyl_trans PF02574.16 AAS53781.2 - 8.5e-54 183.2 0.0 9.6e-54 183.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Metallophos_2 PF12850.7 AAS53782.1 - 1.5e-09 38.2 0.0 2.2e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain tRNA-synt_2b PF00587.25 AAS53783.1 - 2.5e-20 73.2 0.0 4.7e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AAS53783.1 - 0.00078 19.6 0.3 0.0014 18.8 0.3 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain MucB_RseB PF03888.14 AAS53783.1 - 0.032 13.8 0.1 0.051 13.1 0.1 1.3 1 0 0 1 1 1 0 MucB/RseB N-terminal domain HalX PF08663.10 AAS53783.1 - 0.066 13.5 3.0 0.4 11.0 1.3 2.7 1 1 1 2 2 2 0 HalX domain Spectrin PF00435.21 AAS53783.1 - 0.44 11.1 2.1 3.7 8.1 1.9 2.3 2 1 1 3 3 3 0 Spectrin repeat TMF_TATA_bd PF12325.8 AAS53783.1 - 0.85 9.9 4.3 2.4 8.4 4.2 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Ribosomal_L27e PF01777.18 AAS53784.1 - 1.4e-35 121.5 5.2 2.1e-35 120.9 5.2 1.3 1 0 0 1 1 1 1 Ribosomal L27e protein family KOW PF00467.29 AAS53784.1 - 0.0045 16.9 2.1 0.0075 16.2 2.1 1.4 1 0 0 1 1 1 1 KOW motif Ndr PF03096.14 AAS53784.1 - 0.13 10.9 0.0 0.22 10.2 0.0 1.3 1 0 0 1 1 1 0 Ndr family HLH PF00010.26 AAS53785.2 - 8.9e-12 44.8 3.5 8.9e-12 44.8 3.5 1.8 2 0 0 2 2 2 1 Helix-loop-helix DNA-binding domain DUF2465 PF10239.9 AAS53785.2 - 0.0077 15.5 5.7 0.011 14.9 5.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2465) MRP-S31 PF15433.6 AAS53785.2 - 0.011 15.4 6.0 0.017 14.8 5.6 1.5 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Sec66 PF09802.9 AAS53785.2 - 0.024 14.2 3.7 0.037 13.6 3.7 1.3 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 GrpE PF01025.19 AAS53785.2 - 0.028 14.1 4.2 0.054 13.2 4.2 1.4 1 0 0 1 1 1 0 GrpE UPF0175 PF03683.13 AAS53785.2 - 0.068 12.9 0.2 0.22 11.2 0.1 2.0 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0175) Rootletin PF15035.6 AAS53785.2 - 0.083 12.9 8.9 0.14 12.2 8.9 1.2 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion CDC45 PF02724.14 AAS53785.2 - 0.13 10.5 10.1 0.15 10.3 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 AAS53785.2 - 0.21 11.7 20.0 0.46 10.6 19.9 1.6 1 1 0 1 1 1 0 YL1 nuclear protein RasGEF PF00617.19 AAS53785.2 - 0.36 11.0 3.0 0.57 10.4 3.0 1.2 1 0 0 1 1 1 0 RasGEF domain CN_hydrolase PF00795.22 AAS53786.1 - 3.5e-14 52.8 0.0 9.4e-14 51.4 0.0 1.7 2 0 0 2 2 2 1 Carbon-nitrogen hydrolase LicD PF04991.13 AAS53787.2 - 5.6e-49 167.3 0.4 5.6e-49 167.3 0.4 2.6 2 0 0 2 2 2 1 LicD family Hid1 PF12722.7 AAS53787.2 - 8.7 4.3 18.7 12 3.9 18.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TFIIS_C PF01096.18 AAS53788.1 - 8.6e-18 63.9 2.0 8.6e-18 63.9 2.0 2.3 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AAS53788.1 - 7e-09 35.4 7.2 1e-06 28.5 0.1 2.9 2 1 0 2 2 2 2 RNA polymerases M/15 Kd subunit DZR PF12773.7 AAS53788.1 - 2.5e-05 24.2 6.1 0.027 14.5 0.1 2.7 2 1 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 AAS53788.1 - 0.00017 21.2 5.3 0.38 10.5 0.1 3.5 3 0 0 3 3 3 1 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AAS53788.1 - 0.00044 19.7 5.4 0.04 13.4 2.6 2.6 2 1 0 2 2 2 1 TFIIB zinc-binding C1_1 PF00130.22 AAS53788.1 - 0.003 17.4 2.6 0.13 12.1 0.1 2.5 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ribbon_3 PF13248.6 AAS53788.1 - 0.0031 16.9 10.9 1.5 8.4 0.0 3.8 4 0 0 4 4 4 2 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AAS53788.1 - 0.0049 16.8 2.6 0.061 13.3 0.5 2.4 2 0 0 2 2 2 1 Transposase zinc-ribbon domain Baculo_LEF5_C PF11792.8 AAS53788.1 - 0.0097 15.6 0.5 0.0097 15.6 0.5 2.3 3 0 0 3 3 2 1 Baculoviridae late expression factor 5 C-terminal domain zf-C3HC4_3 PF13920.6 AAS53788.1 - 0.02 14.7 3.0 0.83 9.6 0.2 2.9 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TackOD1 PF18551.1 AAS53788.1 - 0.022 14.5 4.0 1.7 8.2 0.1 2.4 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zf-TFIIB PF13453.6 AAS53788.1 - 0.032 13.5 1.0 0.089 12.1 1.0 1.8 1 0 0 1 1 1 0 Transcription factor zinc-finger GATA PF00320.27 AAS53788.1 - 0.038 13.6 0.1 0.038 13.6 0.1 2.0 2 1 0 2 2 1 0 GATA zinc finger zf-RING_10 PF16685.5 AAS53788.1 - 0.044 13.9 2.6 0.16 12.1 0.2 2.4 3 0 0 3 3 2 0 zinc RING finger of MSL2 DUF2072 PF09845.9 AAS53788.1 - 0.089 13.1 0.0 0.089 13.1 0.0 2.2 2 1 1 3 3 2 0 Zn-ribbon containing protein DpnI PF06044.12 AAS53788.1 - 0.089 12.4 1.0 8.2 6.0 0.2 2.1 2 0 0 2 2 2 0 Dam-replacing family ER-remodelling PF14755.6 AAS53788.1 - 0.13 12.5 0.0 0.17 12.2 0.0 1.1 1 0 0 1 1 1 0 Intracellular membrane remodeller zf-C3HC4_4 PF15227.6 AAS53788.1 - 0.19 11.9 0.2 0.19 11.9 0.2 2.8 2 1 1 3 3 2 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 AAS53788.1 - 0.2 11.6 5.6 1.5 8.8 0.3 3.0 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 zf-Mss51 PF13824.6 AAS53788.1 - 0.24 11.5 3.6 0.5 10.5 2.1 2.2 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 Ogr_Delta PF04606.12 AAS53788.1 - 0.28 11.2 7.6 0.23 11.5 5.2 2.1 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger Zn-ribbon_8 PF09723.10 AAS53788.1 - 0.33 11.1 10.0 3.6 7.8 0.1 3.4 3 1 0 3 3 3 0 Zinc ribbon domain zf-C4_Topoisom PF01396.19 AAS53788.1 - 0.38 10.6 7.5 0.073 12.9 1.8 2.5 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_4 PF13717.6 AAS53788.1 - 0.42 10.6 6.2 20 5.2 0.1 3.6 4 0 0 4 4 3 0 zinc-ribbon domain zf-RRN7 PF11781.8 AAS53788.1 - 0.43 10.3 10.8 5.8 6.7 0.1 3.9 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc-ribbons_6 PF07191.12 AAS53788.1 - 0.45 10.5 6.3 7.1 6.7 1.5 2.6 2 2 0 2 2 2 0 zinc-ribbons Nudix_N_2 PF14803.6 AAS53788.1 - 0.47 10.4 10.5 4 7.4 3.5 3.2 2 1 1 3 3 3 0 Nudix N-terminal Zn_Tnp_IS91 PF14319.6 AAS53788.1 - 0.73 9.9 6.6 1.1 9.3 1.9 2.8 1 1 1 2 2 2 0 Transposase zinc-binding domain OrfB_Zn_ribbon PF07282.11 AAS53788.1 - 0.73 9.8 6.6 5.2 7.1 2.3 2.5 2 1 0 2 2 2 0 Putative transposase DNA-binding domain CpXC PF14353.6 AAS53788.1 - 0.82 9.7 7.2 0.69 10.0 0.7 2.9 2 1 2 4 4 3 0 CpXC protein Elf1 PF05129.13 AAS53788.1 - 1 9.4 5.7 0.48 10.5 0.2 2.5 2 1 0 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_4 PF13894.6 AAS53788.1 - 1.9 9.5 10.4 15 6.8 1.0 4.1 3 1 1 4 4 4 0 C2H2-type zinc finger zf-RING_7 PF02591.15 AAS53788.1 - 3.9 7.8 7.7 72 3.7 0.0 3.5 3 1 0 3 3 3 0 C4-type zinc ribbon domain Rubredoxin PF00301.20 AAS53788.1 - 4.9 7.3 9.8 37 4.4 0.3 3.4 4 0 0 4 4 3 0 Rubredoxin DUF3268 PF11672.8 AAS53788.1 - 6.3 7.2 8.1 0.58 10.5 1.0 2.3 2 1 0 2 2 2 0 zinc-finger-containing domain DNA_RNApol_7kD PF03604.13 AAS53788.1 - 9.2 6.1 12.0 8.4 6.2 0.3 3.7 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit Cpn60_TCP1 PF00118.24 AAS53789.1 - 2.5e-153 511.2 2.6 2.9e-153 511.1 2.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family CPT PF07931.12 AAS53789.1 - 0.022 14.6 0.4 8.7 6.1 0.1 3.0 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Actin PF00022.19 AAS53790.1 - 6.7e-91 304.9 0.0 7.6e-54 182.9 0.0 2.1 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 AAS53790.1 - 1.4e-05 24.0 0.0 0.012 14.4 0.0 2.2 2 0 0 2 2 2 2 MreB/Mbl protein FtsA PF14450.6 AAS53790.1 - 0.0011 19.4 0.0 0.0035 17.8 0.0 1.9 2 1 0 2 2 2 1 Cell division protein FtsA FAT PF02259.23 AAS53791.2 - 2.1e-141 471.2 0.5 2.1e-141 471.2 0.5 2.8 3 0 0 3 3 3 1 FAT domain PI3_PI4_kinase PF00454.27 AAS53791.2 - 1.6e-72 244.3 0.0 3.5e-72 243.2 0.0 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF3385 PF11865.8 AAS53791.2 - 2.5e-69 232.3 22.3 3.6e-67 225.3 0.5 5.9 6 1 1 7 7 7 2 Domain of unknown function (DUF3385) FRB_dom PF08771.11 AAS53791.2 - 3.9e-43 145.9 4.0 9.2e-43 144.7 0.4 3.4 3 0 0 3 3 3 1 FKBP12-rapamycin binding domain FATC PF02260.20 AAS53791.2 - 2.4e-17 62.4 0.3 5.7e-17 61.2 0.3 1.7 1 0 0 1 1 1 1 FATC domain HEAT_2 PF13646.6 AAS53791.2 - 5.4e-10 39.5 8.0 0.1 13.0 0.0 8.0 8 1 0 8 8 8 3 HEAT repeats HEAT PF02985.22 AAS53791.2 - 9.5e-08 31.7 10.4 0.03 14.5 0.0 8.0 8 0 0 8 8 8 2 HEAT repeat HEAT_EZ PF13513.6 AAS53791.2 - 7.2e-07 29.6 5.8 0.057 13.9 0.0 8.9 8 1 1 9 9 9 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AAS53791.2 - 0.00058 20.4 10.4 2.1 9.0 0.0 6.4 6 1 0 6 6 6 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 AAS53791.2 - 0.05 13.2 11.8 1.5 8.3 0.0 5.9 3 2 3 7 7 7 0 CLASP N terminal Yae1_N PF09811.9 AAS53792.2 - 7.4e-16 57.6 0.5 1.1e-15 57.0 0.5 1.3 1 0 0 1 1 1 1 Essential protein Yae1, N terminal CutC PF03932.14 AAS53792.2 - 0.04 13.4 0.0 0.055 12.9 0.0 1.2 1 0 0 1 1 1 0 CutC family DUF2959 PF11172.8 AAS53792.2 - 0.083 13.0 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) Rep_fac_C PF08542.11 AAS53793.2 - 1.9e-17 63.5 0.1 4.3e-17 62.3 0.1 1.7 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA PF00004.29 AAS53793.2 - 4.8e-16 59.4 0.0 9.4e-16 58.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.6 AAS53793.2 - 9.9e-14 51.4 0.1 2.1e-12 47.1 0.0 2.6 2 1 0 2 2 2 1 DNA polymerase III, delta subunit Rad17 PF03215.15 AAS53793.2 - 9.4e-09 35.4 0.0 1.8e-08 34.6 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain AAA_assoc_2 PF16193.5 AAS53793.2 - 1.9e-05 24.9 0.2 5.5e-05 23.4 0.2 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_11 PF13086.6 AAS53793.2 - 2.5e-05 24.2 0.1 7.1e-05 22.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AAS53793.2 - 3.4e-05 24.1 0.0 0.00023 21.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AAS53793.2 - 3.9e-05 24.1 0.0 0.0027 18.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 AAS53793.2 - 6.6e-05 22.7 0.0 0.0002 21.1 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 AAS53793.2 - 0.00036 20.0 0.0 0.0089 15.4 0.0 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI ResIII PF04851.15 AAS53793.2 - 0.00094 19.2 0.0 0.0089 16.0 0.0 2.3 2 1 1 3 3 2 1 Type III restriction enzyme, res subunit TrwB_AAD_bind PF10412.9 AAS53793.2 - 0.0014 17.6 0.2 0.42 9.5 0.0 2.2 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 AAS53793.2 - 0.0022 18.1 0.0 0.0055 16.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS53793.2 - 0.0035 17.1 0.0 0.015 15.0 0.0 2.0 2 2 1 3 3 3 1 AAA domain AAA_19 PF13245.6 AAS53793.2 - 0.0036 17.6 0.0 0.02 15.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AAS53793.2 - 0.0043 16.8 0.0 0.0099 15.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain PhoH PF02562.16 AAS53793.2 - 0.0044 16.5 0.5 4.9 6.5 0.1 3.2 3 0 0 3 3 3 1 PhoH-like protein DUF815 PF05673.13 AAS53793.2 - 0.0073 15.5 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_23 PF13476.6 AAS53793.2 - 0.0074 16.8 0.0 0.016 15.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 AAS53793.2 - 0.013 15.0 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_5 PF07728.14 AAS53793.2 - 0.016 15.2 0.0 0.057 13.4 0.0 1.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 AAS53793.2 - 0.052 14.0 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 AAS53793.2 - 0.054 14.0 0.1 0.34 11.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain DUF2075 PF09848.9 AAS53793.2 - 0.057 12.7 0.0 0.21 10.8 0.0 1.9 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 AAS53793.2 - 0.059 13.2 0.1 0.7 9.8 0.0 2.5 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 AAS53793.2 - 0.14 12.4 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain TerB_C PF15615.6 AAS53794.2 - 0.3 11.4 0.1 0.3 11.4 0.1 2.3 4 0 0 4 4 4 0 TerB-C domain PIEZO PF15917.5 AAS53794.2 - 0.91 9.0 0.0 0.91 9.0 0.0 2.6 2 0 0 2 2 2 0 Piezo Xpo1 PF08389.12 AAS53795.2 - 3.4e-43 147.3 1.9 1.2e-42 145.5 0.0 2.9 3 0 0 3 3 3 1 Exportin 1-like protein BEN PF10523.9 AAS53795.2 - 0.029 14.6 0.0 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 BEN domain HEAT PF02985.22 AAS53795.2 - 0.18 12.1 1.8 12 6.5 0.0 4.5 6 0 0 6 6 6 0 HEAT repeat Ham1p_like PF01725.16 AAS53796.1 - 1.7e-53 181.3 0.0 1.9e-53 181.2 0.0 1.0 1 0 0 1 1 1 1 Ham1 family DUF3375 PF11855.8 AAS53796.1 - 0.18 10.7 0.0 3.4 6.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3375) HEAT_2 PF13646.6 AAS53797.2 - 1.8e-33 114.8 2.4 2.4e-16 59.9 0.1 3.2 2 1 1 3 3 3 3 HEAT repeats HEAT_PBS PF03130.16 AAS53797.2 - 2.5e-17 61.7 13.0 0.00012 22.4 0.0 8.4 9 0 0 9 9 9 4 PBS lyase HEAT-like repeat HEAT PF02985.22 AAS53797.2 - 5.4e-12 44.9 1.8 0.0055 16.9 0.1 6.4 7 0 0 7 7 7 2 HEAT repeat HEAT_EZ PF13513.6 AAS53797.2 - 6.2e-06 26.6 7.1 0.0033 17.9 0.1 5.0 4 1 1 5 5 5 1 HEAT-like repeat Cnd1 PF12717.7 AAS53797.2 - 0.0058 16.7 0.8 0.14 12.2 0.1 3.1 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AAS53797.2 - 0.006 16.6 0.2 1.3 9.2 0.0 3.3 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat RuvA_C PF07499.13 AAS53797.2 - 0.14 12.7 0.8 45 4.6 0.0 3.3 3 0 0 3 3 3 0 RuvA, C-terminal domain PAC2 PF09754.9 AAS53798.1 - 2.5e-26 93.0 0.0 3.5e-26 92.6 0.0 1.2 1 0 0 1 1 1 1 PAC2 family ATP_bind_1 PF03029.17 AAS53799.2 - 4.1e-80 269.0 0.3 9.9e-80 267.8 0.0 1.6 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 AAS53799.2 - 2.6e-07 30.4 0.1 3.9e-06 26.5 0.1 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 AAS53799.2 - 1.2e-05 25.2 0.0 3.4e-05 23.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AAS53799.2 - 7.8e-05 22.9 1.2 0.00017 21.8 0.0 2.2 3 0 0 3 3 2 1 AAA domain MMR_HSR1 PF01926.23 AAS53799.2 - 0.00032 20.7 0.0 0.01 15.9 0.0 2.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS53799.2 - 0.00043 19.9 0.0 0.0092 15.5 0.0 2.4 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_22 PF13401.6 AAS53799.2 - 0.00068 19.9 0.1 0.0027 18.0 0.0 2.1 3 0 0 3 3 2 1 AAA domain PduV-EutP PF10662.9 AAS53799.2 - 0.0012 18.6 0.1 0.014 15.1 0.0 2.5 2 1 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 AAS53799.2 - 0.0018 18.2 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 AAS53799.2 - 0.0022 17.7 0.1 0.05 13.2 0.0 2.6 3 0 0 3 3 3 1 SRP54-type protein, GTPase domain CLP1_P PF16575.5 AAS53799.2 - 0.0043 16.9 0.0 1.6 8.5 0.0 3.0 3 0 0 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Arf PF00025.21 AAS53799.2 - 0.0053 16.2 0.0 0.61 9.5 0.0 2.5 2 0 0 2 2 2 1 ADP-ribosylation factor family MeaB PF03308.16 AAS53799.2 - 0.0063 15.5 0.1 2.2 7.2 0.0 2.3 2 0 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AAS53799.2 - 0.008 16.6 0.0 0.028 14.8 0.0 2.0 2 1 1 3 3 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 AAS53799.2 - 0.0094 15.9 0.6 7.9 6.4 0.0 3.3 4 0 0 4 4 3 0 RsgA GTPase Roc PF08477.13 AAS53799.2 - 0.011 15.9 0.0 1.7 8.9 0.0 2.8 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Thymidylate_kin PF02223.17 AAS53799.2 - 0.017 14.8 0.5 0.37 10.4 0.0 2.5 2 0 0 2 2 2 0 Thymidylate kinase AAA_18 PF13238.6 AAS53799.2 - 0.018 15.6 1.0 0.032 14.8 0.0 2.1 3 0 0 3 3 1 0 AAA domain PRK PF00485.18 AAS53799.2 - 0.02 14.7 0.0 0.22 11.2 0.0 2.3 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_7 PF12775.7 AAS53799.2 - 0.02 14.4 0.0 0.041 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 AAS53799.2 - 0.025 15.1 1.3 1.1 9.7 0.3 2.4 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 AAS53799.2 - 0.03 13.5 0.1 0.11 11.7 0.0 1.9 2 0 0 2 2 2 0 NB-ARC domain G-alpha PF00503.20 AAS53799.2 - 0.033 13.3 0.2 0.43 9.7 0.0 2.6 3 0 0 3 3 3 0 G-protein alpha subunit AAA_30 PF13604.6 AAS53799.2 - 0.035 13.8 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 AAS53799.2 - 0.051 13.2 0.2 0.93 9.1 0.2 2.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.10 AAS53799.2 - 0.052 13.0 0.1 1.2 8.5 0.0 2.4 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit U1snRNP70_N PF12220.8 AAS53799.2 - 0.061 14.0 1.8 0.061 14.0 1.8 1.9 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LMBR1 PF04791.16 AAS53799.2 - 1.9 7.3 4.4 0.23 10.3 0.3 1.5 2 0 0 2 2 2 0 LMBR1-like membrane protein EMC3_TMCO1 PF01956.16 AAS53800.1 - 8.1e-55 185.1 1.3 1.1e-54 184.7 1.3 1.2 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like SSDP PF04503.13 AAS53800.1 - 0.047 14.0 0.0 0.078 13.3 0.0 1.3 1 0 0 1 1 1 0 Single-stranded DNA binding protein, SSDP Glyco_hydro_125 PF06824.11 AAS53801.2 - 7.4e-175 581.8 0.0 8.7e-175 581.6 0.0 1.0 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) PEMT PF04191.13 AAS53802.1 - 4.9e-35 120.1 2.0 9.9e-35 119.1 2.0 1.5 1 0 0 1 1 1 1 Phospholipid methyltransferase ABC_membrane PF00664.23 AAS53803.1 - 1.3e-84 284.1 39.2 1.9e-47 162.2 14.1 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AAS53803.1 - 9.3e-62 207.6 0.0 5.7e-30 104.6 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AAS53803.1 - 6.2e-20 71.6 4.4 7.4e-09 35.4 0.1 4.3 3 1 0 4 4 4 3 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 AAS53803.1 - 2e-10 40.1 0.3 0.0045 15.9 0.0 4.6 4 1 0 4 4 4 2 Predicted ATPase of the ABC class AAA_29 PF13555.6 AAS53803.1 - 8.5e-10 38.2 0.8 0.00072 19.3 0.3 2.7 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_22 PF13401.6 AAS53803.1 - 1.8e-07 31.5 2.9 0.0021 18.3 0.1 4.2 3 1 0 3 3 3 2 AAA domain AAA_21 PF13304.6 AAS53803.1 - 3.5e-06 27.0 17.2 0.00086 19.2 0.1 4.5 4 1 0 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AAS53803.1 - 6.3e-06 26.8 5.4 0.041 14.4 0.0 3.2 3 0 0 3 3 3 2 AAA domain RsgA_GTPase PF03193.16 AAS53803.1 - 7.3e-06 26.0 0.0 0.026 14.4 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 AAS53803.1 - 9.4e-06 26.1 0.5 0.11 12.9 0.0 3.7 3 0 0 3 3 3 2 AAA ATPase domain MMR_HSR1 PF01926.23 AAS53803.1 - 3.4e-05 23.9 0.2 0.18 11.9 0.0 2.8 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_30 PF13604.6 AAS53803.1 - 0.0007 19.4 0.6 2.9 7.6 0.0 3.6 3 1 0 3 3 3 1 AAA domain DUF3987 PF13148.6 AAS53803.1 - 0.001 18.2 0.0 0.3 10.0 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3987) AAA_24 PF13479.6 AAS53803.1 - 0.0014 18.4 4.0 0.14 11.8 1.0 3.2 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 AAS53803.1 - 0.0015 17.6 0.0 0.31 10.1 0.0 2.6 2 0 0 2 2 2 1 Type II/IV secretion system protein NB-ARC PF00931.22 AAS53803.1 - 0.0016 17.7 0.2 8.2 5.5 0.0 3.3 3 0 0 3 3 3 0 NB-ARC domain AAA_33 PF13671.6 AAS53803.1 - 0.0022 18.1 1.4 1.3 9.2 0.0 3.5 3 0 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 AAS53803.1 - 0.0038 17.0 0.1 9.8 5.8 0.0 3.4 3 0 0 3 3 3 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 AAS53803.1 - 0.0044 16.3 0.0 0.12 11.7 0.0 2.4 2 0 0 2 2 2 1 Zeta toxin AAA_15 PF13175.6 AAS53803.1 - 0.013 15.3 6.2 0.1 12.3 0.4 2.7 3 0 0 3 3 3 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 AAS53803.1 - 0.013 14.8 0.1 1.3 8.3 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_7 PF12775.7 AAS53803.1 - 0.019 14.5 0.1 2.6 7.5 0.0 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 AAS53803.1 - 0.019 15.0 5.3 0.95 9.5 0.0 3.5 4 0 0 4 4 4 0 Helicase HerA, central domain AAA_5 PF07728.14 AAS53803.1 - 0.019 14.9 0.3 11 6.0 0.0 3.3 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 AAS53803.1 - 0.021 15.2 0.2 8.6 6.8 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_18 PF13238.6 AAS53803.1 - 0.025 15.1 0.2 1.8 9.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 AAS53803.1 - 0.028 13.8 0.6 9.4 5.5 0.1 3.0 3 0 0 3 3 2 0 KaiC Roc PF08477.13 AAS53803.1 - 0.04 14.1 0.1 3.4 7.9 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_25 PF13481.6 AAS53803.1 - 0.041 13.4 0.2 13 5.3 0.0 3.3 3 0 0 3 3 3 0 AAA domain G-alpha PF00503.20 AAS53803.1 - 0.066 12.4 0.0 2.7 7.0 0.0 2.3 2 0 0 2 2 2 0 G-protein alpha subunit NACHT PF05729.12 AAS53803.1 - 0.13 12.1 6.8 6 6.8 0.1 3.9 3 0 0 3 3 3 0 NACHT domain Peptidase_S41 PF03572.18 AAS53803.1 - 0.17 11.4 0.2 0.57 9.7 0.1 1.9 2 0 0 2 2 2 0 Peptidase family S41 cobW PF02492.19 AAS53803.1 - 0.31 10.6 4.2 1 8.9 0.1 3.3 4 0 0 4 4 3 0 CobW/HypB/UreG, nucleotide-binding domain Pox_A32 PF04665.12 AAS53803.1 - 0.41 10.1 5.2 5.1 6.5 0.1 3.0 3 0 0 3 3 3 0 Poxvirus A32 protein DEAD PF00270.29 AAS53803.1 - 0.82 9.4 2.9 2.8 7.7 0.3 3.0 3 1 0 3 3 2 0 DEAD/DEAH box helicase ThiF PF00899.21 AAS53804.1 - 3.6e-109 363.8 0.0 5.5e-75 251.9 0.0 2.2 2 0 0 2 2 2 2 ThiF family UBA_e1_thiolCys PF10585.9 AAS53804.1 - 7.7e-89 297.9 0.5 1.2e-88 297.3 0.5 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site E1_UFD PF09358.10 AAS53804.1 - 4.3e-36 123.5 0.1 1.2e-35 122.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 AAS53804.1 - 9e-28 96.3 0.2 1.8e-27 95.4 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 AAS53804.1 - 6.3e-26 90.4 0.5 1.5e-25 89.2 0.5 1.7 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle SoxY PF13501.6 AAS53804.1 - 0.073 13.3 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Sulfur oxidation protein SoxY Mog1 PF04603.12 AAS53805.2 - 8.9e-34 116.8 0.0 1.2e-33 116.4 0.0 1.2 1 0 0 1 1 1 1 Ran-interacting Mog1 protein Gly_transf_sug PF04488.15 AAS53806.1 - 5e-14 52.7 0.0 1.2e-13 51.4 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif TMEM192 PF14802.6 AAS53806.1 - 0.0043 16.2 0.6 0.006 15.7 0.6 1.2 1 0 0 1 1 1 1 TMEM192 family SlyX PF04102.12 AAS53806.1 - 0.026 15.1 2.0 0.06 14.0 2.0 1.6 1 0 0 1 1 1 0 SlyX PepSY_TM_like_2 PF16357.5 AAS53806.1 - 0.032 14.2 0.0 0.047 13.7 0.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like FlgN PF05130.12 AAS53806.1 - 0.037 14.5 0.8 0.063 13.8 0.8 1.3 1 0 0 1 1 1 0 FlgN protein Herpes_UL6 PF01763.16 AAS53806.1 - 0.055 12.0 0.3 0.079 11.5 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like TMCO5 PF14992.6 AAS53806.1 - 0.072 12.7 3.1 0.12 11.9 3.1 1.3 1 0 0 1 1 1 0 TMCO5 family DUF16 PF01519.16 AAS53806.1 - 0.088 13.3 3.2 0.13 12.7 2.1 1.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 HEPN_RiboL-PSP PF18735.1 AAS53806.1 - 0.19 11.7 0.4 0.38 10.6 0.1 1.9 2 1 0 2 2 2 0 RiboL-PSP-HEPN T3SS_needle_E PF08988.10 AAS53806.1 - 0.23 11.7 1.1 0.45 10.7 1.1 1.5 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle FUSC PF04632.12 AAS53806.1 - 0.44 9.0 0.6 0.61 8.5 0.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Septin PF00735.18 AAS53807.1 - 3.2e-106 354.7 0.0 5.4e-106 354.0 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AAS53807.1 - 5.2e-07 29.7 0.0 1.3e-06 28.5 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AAS53807.1 - 1.6e-05 25.0 7.5 0.0034 17.5 0.2 2.8 3 0 0 3 3 3 2 Dynamin family ABC_tran PF00005.27 AAS53807.1 - 0.00021 21.8 0.8 0.00083 19.9 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 AAS53807.1 - 0.00036 19.9 0.0 0.00036 19.9 0.0 1.9 2 0 0 2 2 2 1 AIG1 family IIGP PF05049.13 AAS53807.1 - 0.00063 18.9 0.1 0.0013 17.9 0.1 1.5 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 AAS53807.1 - 0.00093 19.1 1.7 0.00093 19.1 1.7 2.8 3 1 0 3 3 3 1 RsgA GTPase AAA_23 PF13476.6 AAS53807.1 - 0.014 15.9 4.4 2.3 8.7 4.3 2.4 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 AAS53807.1 - 0.068 13.4 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 AAS53807.1 - 0.073 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 AAS53807.1 - 0.08 13.1 0.3 0.32 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AAS53807.1 - 0.081 12.5 0.0 0.15 11.6 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain FeoB_N PF02421.18 AAS53807.1 - 0.12 11.8 0.3 0.52 9.8 0.3 2.1 1 1 0 1 1 1 0 Ferrous iron transport protein B G-alpha PF00503.20 AAS53807.1 - 0.14 11.3 3.0 0.21 10.7 0.1 2.6 4 0 0 4 4 4 0 G-protein alpha subunit PduV-EutP PF10662.9 AAS53807.1 - 0.17 11.6 0.3 2.4 7.9 0.1 2.3 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation DUF4140 PF13600.6 AAS53807.1 - 0.93 10.0 7.5 0.15 12.5 3.1 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF87 PF01935.17 AAS53807.1 - 3.6 7.6 6.3 21 5.1 0.2 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain HSP20 PF00011.21 AAS53808.1 - 3.3e-18 65.7 0.0 4.8e-18 65.2 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AAS53808.1 - 1e-05 25.0 0.0 2.3e-05 23.9 0.0 1.6 2 0 0 2 2 2 1 HSP20-like domain found in ArsA F-box-like PF12937.7 AAS53809.1 - 9.5e-11 41.4 0.0 1.8e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS53809.1 - 0.00043 20.1 0.0 0.0012 18.6 0.0 1.8 1 1 1 2 2 2 1 F-box domain NAD_binding_1 PF00175.21 AAS53810.1 - 4.5e-27 94.8 0.0 6.9e-27 94.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AAS53810.1 - 2.4e-26 92.0 0.0 3.7e-26 91.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AAS53810.1 - 0.00014 22.0 0.0 0.0086 16.2 0.0 2.2 1 1 0 2 2 2 1 Ferric reductase NAD binding domain DUF4131 PF13567.6 AAS53810.1 - 0.0014 18.3 0.0 0.0023 17.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) FAD_binding_9 PF08021.11 AAS53810.1 - 0.2 11.9 0.0 0.4 10.9 0.0 1.5 1 0 0 1 1 1 0 Siderophore-interacting FAD-binding domain ALO PF04030.14 AAS53811.1 - 3e-108 361.5 0.5 3.8e-108 361.2 0.5 1.1 1 0 0 1 1 1 1 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 AAS53811.1 - 3e-32 111.3 0.1 4.7e-32 110.6 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain BBE PF08031.12 AAS53811.1 - 0.018 15.1 0.1 0.049 13.7 0.1 1.7 1 0 0 1 1 1 0 Berberine and berberine like Tubulin PF00091.25 AAS53812.1 - 4e-65 219.7 0.0 5.8e-65 219.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 AAS53812.1 - 7.8e-50 168.3 0.0 1.2e-49 167.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Sugar_tr PF00083.24 AAS53813.1 - 3e-48 164.8 16.6 3.8e-48 164.5 16.6 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53813.1 - 4e-22 78.6 22.9 1.4e-19 70.3 14.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Ku_N PF03731.15 AAS53814.1 - 1.9e-28 99.7 0.0 2.8e-28 99.2 0.0 1.2 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Ku PF02735.16 AAS53814.1 - 5.8e-21 75.1 0.0 9.4e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 AAS53814.1 - 0.072 13.8 0.1 0.17 12.6 0.1 1.7 1 0 0 1 1 1 0 Ku70/Ku80 C-terminal arm SQS_PSY PF00494.19 AAS53815.1 - 6.7e-39 134.0 0.0 8.8e-39 133.6 0.0 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase Pept_tRNA_hydro PF01195.19 AAS53816.1 - 9e-36 123.4 0.0 1.1e-35 123.1 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase Gtr1_RagA PF04670.12 AAS53817.1 - 1.9e-95 318.7 1.3 1.9e-95 318.7 1.3 1.9 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region Ras PF00071.22 AAS53817.1 - 6.5e-09 35.6 0.1 1.5e-08 34.4 0.1 1.6 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS53817.1 - 2.2e-08 34.4 0.0 6.9e-08 32.7 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS53817.1 - 6.1e-08 32.3 1.1 1.2e-07 31.3 0.1 2.0 2 1 1 3 3 3 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AAS53817.1 - 1.1e-07 32.0 0.0 3.4e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 AAS53817.1 - 0.0053 17.3 0.2 0.013 16.0 0.1 1.9 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 AAS53817.1 - 0.009 15.9 3.0 0.33 10.9 0.1 3.1 3 0 0 3 3 3 1 RsgA GTPase AIG1 PF04548.16 AAS53817.1 - 0.029 13.7 0.6 0.34 10.2 0.1 2.4 1 1 1 2 2 2 0 AIG1 family DUF815 PF05673.13 AAS53817.1 - 0.035 13.3 0.2 0.091 11.9 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 AAS53817.1 - 0.14 11.9 0.2 0.3 10.9 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CRISPR_Cas9_WED PF18061.1 AAS53817.1 - 0.19 11.8 2.8 0.12 12.4 0.4 2.0 2 1 0 2 2 2 0 CRISPR-Cas9 WED domain Guanylate_kin PF00625.21 AAS53817.1 - 0.25 11.0 2.4 0.6 9.8 0.3 2.5 2 1 0 2 2 2 0 Guanylate kinase Pyr_redox_2 PF07992.14 AAS53818.2 - 2.8e-48 164.7 0.0 3.5e-48 164.3 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AAS53818.2 - 1.3e-13 51.3 0.1 7.9e-10 39.2 0.1 3.0 2 2 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AAS53818.2 - 2.4e-06 27.0 0.6 0.46 9.7 0.1 3.2 3 0 0 3 3 3 3 Pyridine nucleotide-disulphide oxidoreductase Mesothelin PF06060.12 AAS53818.2 - 0.04 12.1 0.0 0.39 8.8 0.0 2.0 2 0 0 2 2 2 0 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin) RNB PF00773.19 AAS53819.2 - 7.3e-72 242.4 0.2 1.1e-71 241.9 0.2 1.3 1 0 0 1 1 1 1 RNB domain RIH_assoc PF08454.11 AAS53819.2 - 0.18 11.7 0.1 8.8 6.2 0.0 2.4 2 0 0 2 2 2 0 RyR and IP3R Homology associated MarB PF13999.6 AAS53820.1 - 0.026 14.4 0.0 0.08 12.8 0.0 1.8 1 0 0 1 1 1 0 MarB protein Malate_synthase PF01274.22 AAS53820.1 - 0.084 11.1 0.0 0.12 10.6 0.0 1.2 1 0 0 1 1 1 0 Malate synthase Ribosomal_L30 PF00327.20 AAS53821.1 - 2e-13 50.0 0.3 6.2e-13 48.4 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e Rit1_C PF17184.4 AAS53822.3 - 9.1e-92 307.4 0.0 1.7e-91 306.4 0.0 1.4 1 0 0 1 1 1 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 AAS53822.3 - 5.5e-25 87.8 0.2 5.5e-25 87.8 0.2 2.6 4 0 0 4 4 4 1 Rit1 DUSP-like domain DEAD PF00270.29 AAS53823.3 - 1.8e-47 161.4 0.0 3e-46 157.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS53823.3 - 3.5e-31 107.8 0.0 2.2e-30 105.2 0.1 2.3 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53823.3 - 6.1e-07 29.6 0.0 1.1e-06 28.7 0.0 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS53823.3 - 0.097 12.9 1.4 0.79 10.0 1.4 2.4 1 1 0 1 1 1 0 AAA domain DUF2201 PF09967.9 AAS53823.3 - 0.16 12.1 0.0 0.46 10.6 0.0 1.7 1 0 0 1 1 1 0 VWA-like domain (DUF2201) TPR_1 PF00515.28 AAS53824.3 - 9.3e-22 75.9 0.4 1.7e-06 27.6 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 AAS53824.3 - 3.6e-20 70.4 1.5 4.2e-05 23.3 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 AAS53824.3 - 1.5e-15 56.6 4.1 0.00074 20.1 0.1 5.3 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 AAS53824.3 - 3.9e-15 55.2 1.4 1.7e-06 27.6 0.0 4.4 3 1 2 5 5 5 3 TPR repeat TPR_16 PF13432.6 AAS53824.3 - 9.4e-13 48.6 2.9 0.00012 22.7 0.1 3.9 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 AAS53824.3 - 1.3e-12 46.8 0.2 0.01 16.0 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS53824.3 - 3.1e-11 43.6 2.0 0.047 14.2 0.1 4.6 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_9 PF13371.6 AAS53824.3 - 7.4e-11 42.1 1.9 9.3e-05 22.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 AAS53824.3 - 4.1e-10 39.3 0.6 0.19 12.2 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_20 PF14561.6 AAS53824.3 - 1.1e-09 38.5 1.2 0.013 15.9 0.0 5.0 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 AAS53824.3 - 2.4e-05 24.7 0.4 15 6.5 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 AAS53824.3 - 4.7e-05 23.6 5.2 0.0094 16.2 1.4 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS53824.3 - 0.00073 19.4 0.5 16 5.8 0.0 4.0 4 0 0 4 4 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS53824.3 - 0.0015 18.7 0.7 0.13 12.5 0.2 2.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 AAS53824.3 - 0.061 13.8 2.5 0.15 12.5 0.1 2.6 2 1 1 3 3 3 0 Bacterial transcriptional activator domain TPR_10 PF13374.6 AAS53824.3 - 1.1 9.3 6.0 6 6.9 0.6 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_34 PF05637.12 AAS53825.1 - 5.1e-74 249.0 0.0 6.1e-74 248.7 0.0 1.0 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nucleotid_trans PF03407.16 AAS53825.1 - 0.0072 16.3 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Glyco_tranf_2_4 PF13704.6 AAS53825.1 - 0.1 13.1 0.8 0.24 11.9 0.2 2.1 2 1 0 2 2 2 0 Glycosyl transferase family 2 ARID PF01388.21 AAS53826.1 - 1.6e-13 51.1 2.0 2.3e-13 50.6 0.1 2.3 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Nuc_deoxyrib_tr PF05014.15 AAS53826.1 - 0.04 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase UCMA PF17085.5 AAS53826.1 - 2.3 8.2 13.5 5.6 7.0 13.5 1.6 1 0 0 1 1 1 0 Unique cartilage matrix associated protein ERCC4 PF02732.15 AAS53827.1 - 2e-19 70.3 0.0 1e-18 68.0 0.0 2.3 2 0 0 2 2 2 1 ERCC4 domain MTHFR PF02219.17 AAS53828.1 - 2.6e-107 358.4 0.0 3.4e-107 358.0 0.0 1.1 1 0 0 1 1 1 1 Methylenetetrahydrofolate reductase RMI1_N PF08585.12 AAS53829.1 - 1.1e-16 61.2 0.0 1.4e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 RecQ mediated genome instability protein Ntox34 PF15606.6 AAS53829.1 - 0.073 13.2 0.0 0.28 11.3 0.0 1.9 2 0 0 2 2 2 0 Bacterial toxin 34 Sybindin PF04099.12 AAS53830.1 - 4.4e-38 130.4 0.2 4.8e-22 78.4 0.0 2.0 2 0 0 2 2 2 2 Sybindin-like family Sedlin_N PF04628.13 AAS53830.1 - 4.7e-09 36.4 0.1 7.9e-09 35.7 0.1 1.4 2 0 0 2 2 2 1 Sedlin, N-terminal conserved region DUF3020 PF11223.8 AAS53831.1 - 2e-18 66.6 11.0 2e-18 66.6 11.0 5.8 7 0 0 7 7 7 1 Protein of unknown function (DUF3020) zf-C2H2_4 PF13894.6 AAS53832.1 - 0.0003 21.4 14.3 0.036 14.9 1.0 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS53832.1 - 0.0011 19.2 2.0 0.0011 19.2 2.0 3.9 4 0 0 4 4 4 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS53832.1 - 0.0053 17.1 1.2 0.0053 17.1 1.2 3.7 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2HE PF16278.5 AAS53832.1 - 0.03 14.8 5.3 0.093 13.2 0.1 3.3 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 AAS53832.1 - 0.032 14.9 0.1 0.22 12.2 0.0 2.2 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 AAS53832.1 - 0.068 13.5 5.0 4.5 7.7 0.2 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding PriA_CRR PF18319.1 AAS53832.1 - 0.37 10.8 0.1 0.37 10.8 0.1 2.7 3 0 0 3 3 3 0 PriA DNA helicase Cys-rich region (CRR) domain PyrI_C PF02748.15 AAS53832.1 - 0.68 9.9 2.3 1.7 8.6 0.1 2.4 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain TPT PF03151.16 AAS53833.1 - 5.5e-23 81.7 10.4 2.5e-22 79.6 10.4 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 AAS53833.1 - 4.3e-11 42.6 9.1 7e-11 41.9 9.1 1.3 1 1 0 1 1 1 1 UAA transporter family PUNUT PF16913.5 AAS53833.1 - 1e-07 31.5 7.3 1.6e-07 30.9 7.3 1.2 1 0 0 1 1 1 1 Purine nucleobase transmembrane transport EamA PF00892.20 AAS53833.1 - 8.6e-06 26.0 29.2 0.00024 21.3 4.7 2.8 3 1 0 3 3 3 2 EamA-like transporter family COX14 PF14880.6 AAS53833.1 - 0.2 11.5 0.1 0.2 11.5 0.1 2.1 3 0 0 3 3 3 0 Cytochrome oxidase c assembly EbsA PF17255.2 AAS53833.1 - 0.38 11.1 1.9 0.86 9.9 1.9 1.5 1 0 0 1 1 1 0 EbsA-like protein FixQ PF05545.11 AAS53833.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.2 4 0 0 4 4 4 0 Cbb3-type cytochrome oxidase component FixQ Multi_Drug_Res PF00893.19 AAS53833.1 - 2.8 8.7 8.6 14 6.5 0.6 2.9 2 1 0 2 2 2 0 Small Multidrug Resistance protein Gaa1 PF04114.14 AAS53833.1 - 8.6 5.2 12.9 0.61 9.0 3.8 2.1 2 0 0 2 2 2 0 Gaa1-like, GPI transamidase component MRP-L28 PF09812.9 AAS53834.1 - 5.3e-31 107.9 0.1 6.4e-31 107.7 0.1 1.0 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L28 THDPS_N_2 PF14805.6 AAS53834.1 - 0.0018 18.5 0.0 0.0033 17.6 0.0 1.4 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal Esterase_phd PF10503.9 AAS53834.1 - 0.092 12.2 0.5 0.14 11.6 0.5 1.3 1 1 0 1 1 1 0 Esterase PHB depolymerase Ras PF00071.22 AAS53835.1 - 2.3e-51 173.6 0.0 4.1e-51 172.8 0.0 1.4 2 0 0 2 2 2 1 Ras family Roc PF08477.13 AAS53835.1 - 2.7e-17 63.1 0.0 4.1e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS53835.1 - 3e-09 36.6 0.1 3.7e-09 36.3 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 AAS53835.1 - 5.1e-05 22.9 0.0 0.00014 21.5 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS53835.1 - 0.00023 21.1 0.0 0.29 11.0 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase Gly_transf_sug PF04488.15 AAS53836.1 - 1.1e-13 51.7 0.0 2.4e-13 50.5 0.0 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif RNase_3_N PF18497.1 AAS53836.1 - 0.2 11.9 0.0 0.41 10.9 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease III N-terminal domain Isochorismatase PF00857.20 AAS53837.2 - 2.4e-27 96.2 0.0 3.8e-27 95.6 0.0 1.3 1 1 0 1 1 1 1 Isochorismatase family NUC153 PF08159.12 AAS53839.1 - 9.9e-10 38.1 3.1 1.7e-09 37.3 3.1 1.4 1 0 0 1 1 1 1 NUC153 domain WD40 PF00400.32 AAS53839.1 - 0.0063 17.3 0.2 11 7.0 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat BUD22 PF09073.10 AAS53839.1 - 0.009 15.4 23.0 0.02 14.2 23.0 1.5 1 0 0 1 1 1 1 BUD22 G0-G1_switch_2 PF15103.6 AAS53840.1 - 6.8 7.2 12.0 0.67 10.4 3.9 2.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 Ecl1 PF12855.7 AAS53841.1 - 1.2e-07 33.1 5.6 1.8e-07 32.5 5.6 1.4 1 1 0 1 1 1 1 ECL1/2/3 zinc binding proteins Metallothio_Pro PF02069.16 AAS53841.1 - 0.091 13.0 1.3 0.18 12.1 1.3 1.5 1 0 0 1 1 1 0 Prokaryotic metallothionein zf-C2H2 PF00096.26 AAS53842.1 - 8.2e-10 38.6 10.6 3.6e-05 24.0 1.1 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS53842.1 - 6.4e-09 35.8 14.3 2.4e-06 27.7 1.6 3.7 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 AAS53842.1 - 0.00018 21.4 1.0 0.026 14.5 0.1 2.8 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AAS53842.1 - 0.00045 20.8 14.3 0.028 15.2 0.5 3.4 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AAS53842.1 - 0.058 13.7 0.3 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-Di19 PF05605.12 AAS53842.1 - 0.8 10.0 3.4 0.79 10.1 0.1 2.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 AAS53842.1 - 0.8 9.7 2.7 30 4.7 0.2 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-H2C2_5 PF13909.6 AAS53842.1 - 4.7 7.1 9.6 25 4.7 1.1 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain Mfp-3 PF04202.13 AAS53843.2 - 0.098 13.1 1.0 0.16 12.4 0.0 1.8 2 0 0 2 2 2 0 Foot protein 3 TBPIP PF07106.13 AAS53845.2 - 4.9e-29 100.0 2.2 3.9e-28 97.2 0.1 2.9 3 0 0 3 3 3 1 TBPIP/Hop2 winged helix domain Cluap1 PF10234.9 AAS53845.2 - 9.6e-05 21.9 6.2 9.6e-05 21.9 6.2 1.6 1 1 0 1 1 1 1 Clusterin-associated protein-1 MIS13 PF08202.11 AAS53845.2 - 0.0043 16.4 6.6 0.0059 15.9 6.6 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family TPR_MLP1_2 PF07926.12 AAS53845.2 - 0.012 15.7 13.2 0.17 12.0 8.5 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 AAS53845.2 - 0.019 15.4 7.2 0.019 15.4 7.2 2.2 1 1 1 2 2 2 0 Spectrin repeat PilJ PF13675.6 AAS53845.2 - 0.047 13.7 1.5 0.088 12.8 1.5 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term KELK PF15796.5 AAS53845.2 - 0.13 12.7 11.1 1.4 9.4 4.0 3.0 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Phage_GP20 PF06810.11 AAS53845.2 - 0.16 11.7 11.1 0.22 11.3 0.5 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 TMPIT PF07851.13 AAS53845.2 - 0.19 11.0 5.9 0.27 10.5 5.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein YkyA PF10368.9 AAS53845.2 - 0.95 9.1 14.8 0.24 11.1 1.3 2.8 1 1 2 3 3 3 0 Putative cell-wall binding lipoprotein LXG PF04740.12 AAS53845.2 - 1.1 8.9 8.1 7.4 6.2 0.1 3.1 1 1 2 3 3 3 0 LXG domain of WXG superfamily NPV_P10 PF05531.12 AAS53845.2 - 1.3 9.5 7.9 0.59 10.6 3.9 2.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein LRS4 PF10422.9 AAS53845.2 - 1.5 8.4 8.1 1.9 8.0 8.1 1.3 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Syntaxin-6_N PF09177.11 AAS53845.2 - 1.8 9.1 8.2 1.2 9.7 6.3 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CCDC-167 PF15188.6 AAS53845.2 - 2.3 8.6 11.6 0.18 12.1 0.9 2.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF948 PF06103.11 AAS53845.2 - 4.9 7.5 8.1 11 6.3 1.2 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF349 PF03993.12 AAS53845.2 - 5.6 7.3 14.1 1.9 8.8 0.9 3.3 3 0 0 3 3 3 0 Domain of Unknown Function (DUF349) Uso1_p115_C PF04871.13 AAS53845.2 - 6.1 7.2 11.4 2.5 8.5 4.9 2.3 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.9 AAS53845.2 - 6.4 7.0 18.9 2.5 8.3 1.7 2.7 2 2 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF1279 PF06916.13 AAS53846.1 - 2.1e-25 89.1 0.1 3.3e-25 88.4 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1279) Cas_Csx8 PF09657.10 AAS53846.1 - 0.079 11.9 0.1 0.1 11.6 0.1 1.1 1 0 0 1 1 1 0 CRISPR-associated protein Csx8 (Cas_Csx8) Myc-LZ PF02344.15 AAS53846.1 - 0.13 12.4 4.3 0.28 11.3 4.3 1.6 1 0 0 1 1 1 0 Myc leucine zipper domain Ribosomal_L24e PF01246.20 AAS53848.1 - 4.7e-30 103.6 0.2 4.7e-30 103.6 0.2 1.9 2 1 0 2 2 2 1 Ribosomal protein L24e DDHD PF02862.17 AAS53848.1 - 1.8 8.7 7.2 2.2 8.4 7.2 1.1 1 0 0 1 1 1 0 DDHD domain Ribosomal_L7Ae PF01248.26 AAS53849.1 - 3.4e-24 84.4 0.1 3.8e-24 84.2 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF2838 PF10998.8 AAS53850.2 - 3.4e-40 136.7 12.1 3.4e-40 136.7 12.1 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF2838) PPR_2 PF13041.6 AAS53851.1 - 8.2e-15 54.7 1.7 9.5e-09 35.3 0.1 3.5 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.6 AAS53851.1 - 3.3e-06 27.1 0.3 0.0039 17.2 0.0 3.7 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 AAS53851.1 - 0.082 12.3 1.9 0.35 10.2 0.1 2.7 2 1 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP Vac14_Fig4_bd PF11916.8 AAS53851.1 - 0.12 12.1 2.3 1.2 8.8 0.2 2.4 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding PPR PF01535.20 AAS53851.1 - 0.23 11.8 4.8 0.41 11.0 0.0 3.8 5 0 0 5 5 5 0 PPR repeat Cgr1 PF03879.14 AAS53852.1 - 2.3e-33 114.8 34.7 2.6e-33 114.6 34.7 1.0 1 0 0 1 1 1 1 Cgr1 family DUF2048 PF09752.9 AAS53852.1 - 0.061 12.4 3.6 0.067 12.3 3.6 1.1 1 0 0 1 1 1 0 Abhydrolase domain containing 18 DnaG_DnaB_bind PF08278.11 AAS53852.1 - 0.093 13.3 9.7 0.15 12.6 9.7 1.3 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding MIOX PF05153.15 AAS53853.1 - 8.3e-117 389.1 5.3 1e-116 388.8 5.3 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase HD PF01966.22 AAS53853.1 - 0.0021 18.3 0.2 0.34 11.1 0.2 2.6 1 1 0 1 1 1 1 HD domain DUF1796 PF08795.10 AAS53853.1 - 0.034 14.1 0.1 0.061 13.3 0.1 1.5 1 0 0 1 1 1 0 Putative papain-like cysteine peptidase (DUF1796) Glyco_hydro_63 PF03200.16 AAS53854.2 - 3.9e-160 533.9 5.3 6e-160 533.2 2.1 2.4 2 1 0 2 2 2 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 AAS53854.2 - 6.8e-63 212.8 0.1 1.2e-62 212.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain GDE_C PF06202.14 AAS53854.2 - 0.00042 19.4 0.1 0.00078 18.5 0.1 1.4 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Trehalase PF01204.18 AAS53854.2 - 0.0017 17.3 0.2 0.0029 16.5 0.2 1.3 1 0 0 1 1 1 1 Trehalase Rrn6 PF10214.9 AAS53855.2 - 1.7e-104 351.1 36.6 9.2e-103 345.4 36.6 3.2 1 1 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Trp_syntA PF00290.20 AAS53856.1 - 6.6e-92 307.0 0.1 9.8e-92 306.5 0.1 1.2 1 0 0 1 1 1 1 Tryptophan synthase alpha chain PALP PF00291.25 AAS53856.1 - 1.3e-48 165.9 1.0 2.7e-48 164.9 1.0 1.5 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme Med3 PF11593.8 AAS53857.2 - 2.3e-30 106.1 26.1 3.4e-23 82.5 0.1 2.3 1 1 1 2 2 2 2 Mediator complex subunit 3 fungal Mod_r PF07200.13 AAS53857.2 - 0.019 15.1 0.5 0.029 14.5 0.5 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein UL17 PF17640.2 AAS53858.2 - 0.11 12.5 0.0 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 Uncharacterized UL17 Formyl_trans_N PF00551.19 AAS53859.2 - 1.9e-30 106.0 0.0 2.5e-30 105.5 0.0 1.1 1 0 0 1 1 1 1 Formyl transferase Acyltransferase PF01553.21 AAS53860.2 - 4.3e-09 36.1 0.0 1.9e-08 34.0 0.0 2.0 1 1 0 1 1 1 1 Acyltransferase FYVE PF01363.21 AAS53861.1 - 1.5e-14 53.9 6.7 2.8e-14 53.0 6.7 1.5 1 0 0 1 1 1 1 FYVE zinc finger STT3 PF02516.14 AAS53862.1 - 2.6e-151 504.9 37.4 5.9e-149 497.1 34.6 2.1 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 AAS53862.1 - 0.0018 18.5 12.2 0.0018 18.5 12.2 2.6 3 0 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase 60KD_IMP PF02096.20 AAS53862.1 - 0.056 13.3 2.9 0.066 13.1 0.2 2.5 2 1 0 2 2 2 0 60Kd inner membrane protein Haspin_kinase PF12330.8 AAS53863.1 - 2.6e-86 289.9 3.9 4.9e-86 289.0 3.9 1.5 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_Tyr PF07714.17 AAS53863.1 - 6.6e-06 25.6 0.0 1.1e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 AAS53863.1 - 0.00078 18.9 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain dCMP_cyt_deam_1 PF00383.23 AAS53864.1 - 1.6e-09 37.5 0.0 2.4e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AAS53864.1 - 1.1e-05 25.2 0.1 1.8e-05 24.5 0.1 1.3 1 0 0 1 1 1 1 MafB19-like deaminase Bd3614-deam PF14439.6 AAS53864.1 - 0.044 13.9 0.0 0.073 13.1 0.0 1.3 1 0 0 1 1 1 0 Bd3614-like deaminase Telomerase_RBD PF12009.8 AAS53865.1 - 3.5e-24 85.4 0.8 3.5e-24 85.4 0.8 2.2 2 0 0 2 2 2 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 AAS53865.1 - 3.9e-11 42.9 0.4 5.5e-07 29.3 0.0 2.5 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2441 PF10386.9 AAS53865.1 - 0.0067 16.4 0.0 0.033 14.2 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2441) AIP3 PF03915.13 AAS53866.1 - 1.7e-135 452.3 14.4 1.7e-135 452.3 14.4 1.9 2 0 0 2 2 2 1 Actin interacting protein 3 RE_MjaI PF09568.10 AAS53866.1 - 0.015 15.1 0.1 0.045 13.6 0.1 1.8 1 0 0 1 1 1 0 MjaI restriction endonuclease HSBP1 PF06825.12 AAS53866.1 - 0.034 14.0 5.7 0.27 11.1 0.2 3.5 3 0 0 3 3 3 0 Heat shock factor binding protein 1 T3SS_needle_E PF08988.10 AAS53866.1 - 0.066 13.4 3.1 0.18 11.9 0.1 3.2 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle KinB_sensor PF16767.5 AAS53866.1 - 0.068 13.6 2.4 0.91 10.0 0.0 3.4 2 1 1 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB DUF3810 PF12725.7 AAS53866.1 - 1.5 8.1 4.7 2.2 7.6 1.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3810) DUF1640 PF07798.11 AAS53866.1 - 1.6 8.8 15.1 0.21 11.6 1.7 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1640) DUF4298 PF14131.6 AAS53866.1 - 3.4 7.7 14.0 0.087 12.8 3.6 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4298) Mus7 PF09462.10 AAS53867.1 - 3.3e-81 274.0 17.9 2.9e-58 198.2 10.6 2.1 1 1 1 2 2 2 2 Mus7/MMS22 family Phage_Mu_F PF04233.14 AAS53867.1 - 0.22 12.3 1.7 2.5 8.9 0.5 2.8 3 0 0 3 3 3 0 Phage Mu protein F like protein SANT_DAMP1_like PF16282.5 AAS53868.1 - 1.6e-27 95.5 5.0 1.6e-27 95.5 5.0 2.4 2 0 0 2 2 2 1 SANT/Myb-like domain of DAMP1 DMAP1 PF05499.12 AAS53868.1 - 5.1e-05 23.2 1.6 5.1e-05 23.2 1.6 2.6 2 2 0 2 2 2 1 DNA methyltransferase 1-associated protein 1 (DMAP1) Myb_DNA-bind_6 PF13921.6 AAS53868.1 - 0.051 13.8 0.2 0.051 13.8 0.2 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain Cullin PF00888.22 AAS53869.2 - 5.4e-117 392.0 0.0 8.3e-117 391.3 0.0 1.3 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 AAS53869.2 - 1e-17 63.9 0.5 3.6e-17 62.1 0.5 2.0 1 0 0 1 1 1 1 Cullin protein neddylation domain CvfB_WH PF17783.1 AAS53869.2 - 0.0094 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 CvfB-like winged helix domain TrmB PF01978.19 AAS53869.2 - 0.037 13.9 0.0 0.35 10.8 0.0 2.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB DUF488 PF04343.13 AAS53869.2 - 0.046 14.3 0.0 0.15 12.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF488 zf-CCCH PF00642.24 AAS53870.1 - 1.7e-09 37.3 3.4 1.7e-09 37.3 3.4 2.0 2 0 0 2 2 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 AAS53870.1 - 1.6e-06 27.9 5.5 3e-06 27.0 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS53870.1 - 2.6e-06 27.1 4.9 5.1e-06 26.2 4.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS53870.1 - 5.7e-06 26.2 8.0 1e-05 25.4 8.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf_CCCH_4 PF18345.1 AAS53870.1 - 1.7e-05 24.7 5.6 3.1e-05 23.9 5.6 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-C3HC4 PF00097.25 AAS53870.1 - 7.3e-05 22.6 4.0 0.00012 21.8 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS53870.1 - 7.5e-05 23.0 5.9 0.00015 22.0 5.9 1.5 1 0 0 1 1 1 1 Ring finger domain zf-CCCH_4 PF18044.1 AAS53870.1 - 0.001 18.8 2.2 0.001 18.8 2.2 2.3 2 0 0 2 2 2 1 CCCH-type zinc finger Prok-RING_4 PF14447.6 AAS53870.1 - 0.0014 18.5 4.1 0.0025 17.6 4.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AAS53870.1 - 0.0015 18.7 4.4 0.0038 17.4 4.4 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_10 PF16685.5 AAS53870.1 - 0.0061 16.7 3.4 0.0061 16.7 3.4 1.8 2 0 0 2 2 2 1 zinc RING finger of MSL2 zf-RING_UBOX PF13445.6 AAS53870.1 - 0.017 15.2 6.8 0.036 14.1 6.8 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Pex24p PF06398.11 AAS53871.1 - 7.4e-97 324.6 4.5 9.5e-97 324.2 4.5 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Ribosomal_L38e PF01781.18 AAS53872.1 - 1.6e-27 95.4 2.2 1.8e-27 95.2 2.2 1.0 1 0 0 1 1 1 1 Ribosomal L38e protein family TFIIF_beta_N PF17683.1 AAS53873.1 - 1.7e-37 129.1 5.3 4.3e-37 127.8 5.3 1.7 1 0 0 1 1 1 1 TFIIF, beta subunit N-terminus TFIIF_beta PF02270.15 AAS53873.1 - 1.7e-27 95.3 1.9 3.2e-27 94.4 1.9 1.5 1 0 0 1 1 1 1 TFIIF, beta subunit HTH domain Tau95 PF09734.9 AAS53873.1 - 0.0054 17.5 0.2 0.0054 17.5 0.2 2.4 1 1 1 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Prp18 PF02840.15 AAS53874.2 - 1.6e-30 106.1 0.0 2.2e-30 105.6 0.0 1.3 1 1 0 1 1 1 1 Prp18 domain CTP_transf_like PF01467.26 AAS53875.2 - 3.2e-28 98.7 0.0 1.5e-22 80.3 0.0 2.1 2 0 0 2 2 2 2 Cytidylyltransferase-like FAD_syn PF06574.12 AAS53875.2 - 0.0012 18.8 0.2 5.3 6.9 0.2 3.1 2 1 0 2 2 2 2 FAD synthetase Herpes_UL37_2 PF07413.11 AAS53875.2 - 0.22 10.7 0.0 0.34 10.1 0.0 1.2 1 0 0 1 1 1 0 Betaherpesvirus immediate-early glycoprotein UL37 HABP4_PAI-RBP1 PF04774.15 AAS53876.1 - 0.00082 20.2 0.1 0.001 19.9 0.1 1.2 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family HSP9_HSP12 PF04119.12 AAS53877.1 - 1.4e-50 169.5 32.2 1e-09 38.7 0.8 7.8 2 2 6 8 8 8 7 Heat shock protein 9/12 Apolipoprotein PF01442.18 AAS53877.1 - 3.2e-05 23.9 17.2 0.012 15.4 13.9 4.1 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain Spt5-NGN PF03439.13 AAS53877.1 - 0.0076 16.1 0.1 32 4.5 0.0 4.6 1 1 4 5 5 5 0 Early transcription elongation factor of RNA pol II, NGN section Mtc PF03820.17 AAS53877.1 - 0.01 14.9 4.4 3.4 6.6 0.2 3.5 1 1 3 4 4 4 0 Tricarboxylate carrier ApoA-II PF04711.13 AAS53877.1 - 0.018 15.2 0.3 12 6.2 0.0 4.4 1 1 3 5 5 5 0 Apolipoprotein A-II (ApoA-II) DUF3813 PF12758.7 AAS53877.1 - 0.028 14.7 8.7 10 6.5 0.1 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF3813) MIT PF04212.18 AAS53877.1 - 0.1 12.7 7.4 35 4.6 0.1 5.6 6 1 0 6 6 6 0 MIT (microtubule interacting and transport) domain YtxH PF12732.7 AAS53877.1 - 0.55 10.8 24.3 1.8e+04 -13.1 24.2 5.2 1 1 0 1 1 1 0 YtxH-like protein SNARE PF05739.19 AAS53877.1 - 6.9 6.8 28.3 13 5.9 0.0 7.8 9 0 0 9 9 9 0 SNARE domain DnaJ PF00226.31 AAS53878.1 - 1.3e-24 86.1 3.9 2.6e-24 85.1 3.9 1.5 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 AAS53878.1 - 2.1e-23 83.0 0.0 3.1e-23 82.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 AAS53878.1 - 2.6e-09 37.3 20.4 4.3e-09 36.6 20.4 1.4 1 0 0 1 1 1 1 DnaJ central domain HypA PF01155.19 AAS53878.1 - 3.9 7.5 7.8 2.3 8.3 1.5 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2318 PF10080.9 AAS53878.1 - 9.6 6.4 8.5 21 5.3 0.9 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DUF2781 PF10914.8 AAS53879.1 - 1.3e-38 132.7 15.4 1.5e-38 132.5 15.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2781) Acetyltransf_1 PF00583.25 AAS53881.1 - 1.1e-12 48.2 0.1 1.6e-12 47.7 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AAS53881.1 - 6.7e-08 32.8 0.0 9.8e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AAS53881.1 - 7.8e-07 29.1 0.0 2e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain LSM PF01423.22 AAS53882.1 - 1.2e-17 63.3 0.2 1.3e-17 63.2 0.2 1.0 1 0 0 1 1 1 1 LSM domain Pyr_redox_2 PF07992.14 AAS53883.2 - 1.2e-67 228.2 5.1 1.9e-67 227.6 5.1 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AAS53883.2 - 1.1e-43 148.0 0.1 2.8e-43 146.7 0.1 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AAS53883.2 - 4.7e-22 78.3 7.2 2.2e-19 69.8 0.4 3.6 4 1 0 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AAS53883.2 - 3.2e-12 46.5 2.4 1.1e-05 25.6 0.3 3.2 2 1 1 3 3 3 2 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 AAS53883.2 - 3.9e-11 43.0 8.1 2.5e-10 40.3 0.5 3.1 2 1 1 3 3 3 1 FAD dependent oxidoreductase GIDA PF01134.22 AAS53883.2 - 7.5e-11 41.7 5.9 4.8e-09 35.8 2.7 2.6 2 1 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 AAS53883.2 - 2.3e-10 40.2 6.2 1e-07 31.5 0.3 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AAS53883.2 - 5e-08 32.1 8.5 0.00057 18.7 0.8 4.1 3 1 1 4 4 4 3 HI0933-like protein FAD_binding_2 PF00890.24 AAS53883.2 - 3.4e-07 29.7 1.7 3.4e-07 29.7 1.7 2.7 2 1 1 3 3 3 1 FAD binding domain AlaDh_PNT_C PF01262.21 AAS53883.2 - 6.9e-07 28.8 1.7 0.0054 16.0 0.2 2.8 3 0 0 3 3 3 2 Alanine dehydrogenase/PNT, C-terminal domain DAO PF01266.24 AAS53883.2 - 2e-05 24.4 17.3 0.75 9.3 1.5 4.8 2 2 2 4 4 4 4 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AAS53883.2 - 3.5e-05 23.2 8.7 0.012 14.8 0.6 3.5 3 1 0 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 AAS53883.2 - 0.00017 20.9 1.0 0.5 9.4 0.1 3.1 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 AAS53883.2 - 0.0016 17.8 5.8 0.0048 16.2 0.6 2.3 1 1 1 2 2 2 1 Thi4 family XdhC_C PF13478.6 AAS53883.2 - 0.03 14.8 0.1 7.3 7.1 0.0 2.6 2 0 0 2 2 2 0 XdhC Rossmann domain 3HCDH_N PF02737.18 AAS53883.2 - 0.04 13.8 0.1 0.04 13.8 0.1 2.5 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 AAS53883.2 - 0.069 12.5 0.6 0.2 11.0 0.1 2.0 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Lycopene_cycl PF05834.12 AAS53883.2 - 0.091 11.8 1.7 6.4 5.7 0.1 2.2 2 0 0 2 2 2 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 AAS53883.2 - 0.11 12.9 1.0 4.5 7.8 0.1 2.9 2 0 0 2 2 2 0 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 AAS53883.2 - 0.16 11.5 2.7 0.55 9.8 0.1 2.4 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Trp_halogenase PF04820.14 AAS53883.2 - 0.45 9.3 3.4 2.2 7.0 0.4 2.2 2 0 0 2 2 2 0 Tryptophan halogenase GATA PF00320.27 AAS53884.2 - 3.9e-16 58.3 1.8 3.9e-16 58.3 1.8 1.9 2 0 0 2 2 2 1 GATA zinc finger DUF1752 PF08550.10 AAS53884.2 - 7.7e-07 28.8 2.7 1.7e-06 27.7 2.7 1.7 1 0 0 1 1 1 1 Fungal protein of unknown function (DUF1752) Fcf2 PF08698.11 AAS53885.1 - 9.7e-34 115.7 0.0 1.7e-33 114.9 0.0 1.3 1 0 0 1 1 1 1 Fcf2 pre-rRNA processing FANC_SAP PF18081.1 AAS53885.1 - 0.0077 16.4 0.9 0.056 13.6 0.0 2.8 3 0 0 3 3 3 1 Fanconi anemia-associated nuclease SAP domain tRNA-synt_2d PF01409.20 AAS53887.1 - 2.6e-89 298.9 0.0 3.7e-89 298.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) PheRS_DBD3 PF18553.1 AAS53887.1 - 4.8e-14 52.4 1.0 2.5e-13 50.1 0.2 2.5 3 0 0 3 3 3 1 PheRS DNA binding domain 3 PheRS_DBD2 PF18554.1 AAS53887.1 - 7.7e-09 35.4 4.1 1.7e-08 34.3 4.1 1.7 1 0 0 1 1 1 1 PheRS DNA binding domain 2 tRNA_synthFbeta PF17759.1 AAS53887.1 - 1.5e-07 31.1 0.0 0.00011 21.7 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AAS53887.1 - 3.1e-05 23.2 0.1 0.00076 18.6 0.0 2.4 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 AAS53887.1 - 0.00027 21.0 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) PaaX PF07848.12 AAS53887.1 - 0.053 13.8 0.0 1.6 9.0 0.0 2.8 3 0 0 3 3 3 0 PaaX-like protein DNA_pol_phi PF04931.13 AAS53888.1 - 0.5 8.4 14.8 1.2 7.2 14.8 1.6 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 AAS53888.1 - 2 8.1 23.3 0.91 9.3 4.2 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein MSA_2 PF00985.17 AAS53888.1 - 2.3 8.5 9.7 5.1 7.4 9.7 1.5 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family TRAP_alpha PF03896.16 AAS53888.1 - 5.7 6.0 6.9 13 4.9 6.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit GCR1_C PF12550.8 AAS53889.1 - 2e-09 37.6 1.4 3.7e-08 33.6 1.4 2.4 1 1 0 1 1 1 1 Transcriptional activator of glycolytic enzymes DUF3835 PF12927.7 AAS53890.2 - 6.8e-16 58.9 0.0 6.8e-16 58.9 0.0 5.2 4 1 1 5 5 5 1 Domain of unknown function (DUF3835) Prefoldin PF02996.17 AAS53890.2 - 7.7e-08 32.3 0.0 2.4e-07 30.7 0.0 1.9 2 0 0 2 2 2 1 Prefoldin subunit EPL1 PF10513.9 AAS53891.2 - 8e-24 84.8 2.7 8e-24 84.8 2.7 3.5 3 1 0 3 3 3 1 Enhancer of polycomb-like DUF3788 PF12663.7 AAS53891.2 - 0.017 15.1 0.1 0.05 13.6 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3788) PGAP1 PF07819.13 AAS53892.2 - 3.1e-99 331.4 0.0 4.9e-99 330.7 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein Palm_thioest PF02089.15 AAS53892.2 - 0.0074 16.1 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 AAS53892.2 - 0.024 15.3 0.0 0.046 14.3 0.0 1.6 1 0 0 1 1 1 0 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS53892.2 - 0.027 13.7 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 AAS53892.2 - 0.033 13.9 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF676 PF05057.14 AAS53892.2 - 0.041 13.4 0.0 0.076 12.5 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_1 PF00561.20 AAS53892.2 - 0.05 13.2 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 AAS53892.2 - 0.058 13.0 0.0 0.098 12.3 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.25 AAS53892.2 - 0.13 12.1 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DUF2974 PF11187.8 AAS53892.2 - 0.16 11.5 0.0 0.26 10.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) STE2 PF02116.15 AAS53893.1 - 5.6e-77 258.8 29.1 6.7e-77 258.5 29.1 1.1 1 0 0 1 1 1 1 Fungal pheromone mating factor STE2 GPCR CybS PF05328.12 AAS53894.1 - 2.6e-55 185.7 0.0 3.1e-55 185.5 0.0 1.0 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit Sdh_cyt PF01127.22 AAS53894.1 - 0.0037 17.3 0.7 0.091 12.8 0.7 2.3 1 1 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Acyltransferase PF01553.21 AAS53895.1 - 0.00072 19.2 0.0 0.0017 18.0 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase Acyltransf_C PF16076.5 AAS53895.1 - 0.001 19.1 0.6 0.0028 17.7 0.6 1.7 1 0 0 1 1 1 1 Acyltransferase C-terminus RRT14 PF17075.5 AAS53895.1 - 0.41 10.7 3.3 0.84 9.7 3.3 1.4 1 1 0 1 1 1 0 Regular of rDNA transcription protein 14 LRR_6 PF13516.6 AAS53896.1 - 4.3e-06 26.3 9.9 0.75 10.0 0.3 6.6 8 0 0 8 8 8 3 Leucine Rich repeat LRR_1 PF00560.33 AAS53896.1 - 4.6e-05 23.4 0.5 53 5.0 0.0 6.0 7 0 0 7 7 7 0 Leucine Rich Repeat LRR_4 PF12799.7 AAS53896.1 - 7.5e-05 23.0 8.2 2.7 8.6 0.6 6.4 5 1 3 8 8 8 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 AAS53896.1 - 0.0054 16.5 9.6 2 8.2 0.0 5.5 6 1 0 6 6 6 2 Leucine rich repeat ACP_syn_III_C PF08541.10 AAS53896.1 - 0.045 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal MBF1 PF08523.10 AAS53897.1 - 3.1e-23 82.0 1.9 4.5e-23 81.5 1.4 1.5 2 0 0 2 2 2 1 Multiprotein bridging factor 1 HTH_3 PF01381.22 AAS53897.1 - 2.7e-13 49.8 0.1 4.8e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AAS53897.1 - 5.2e-06 26.7 0.1 1.3e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 AAS53897.1 - 0.00043 20.2 0.1 0.00072 19.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_38 PF13936.6 AAS53897.1 - 0.01 15.6 0.0 0.045 13.5 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain TFIID-31kDa PF02291.15 AAS53898.1 - 9.3e-50 167.8 0.1 1.1e-49 167.6 0.1 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Rtt102p PF09510.10 AAS53898.1 - 0.078 13.2 0.0 0.16 12.1 0.0 1.5 2 0 0 2 2 2 0 Rtt102p-like transcription regulator protein ChAPs PF09295.10 AAS53899.2 - 1.2e-172 574.4 0.1 1.5e-172 574.1 0.1 1.1 1 0 0 1 1 1 1 ChAPs (Chs5p-Arf1p-binding proteins) TPR_1 PF00515.28 AAS53899.2 - 0.036 13.9 0.3 0.2 11.5 0.6 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 AAS53899.2 - 0.06 14.0 0.8 5.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat RNase_3_N PF18497.1 AAS53899.2 - 0.1 12.8 0.3 0.23 11.7 0.3 1.6 1 0 0 1 1 1 0 Ribonuclease III N-terminal domain TPR_2 PF07719.17 AAS53899.2 - 0.15 12.3 4.7 0.38 11.0 1.3 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 AAS53899.2 - 0.3 11.4 1.2 88 3.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS53899.2 - 2 8.7 7.4 2.9 8.2 0.4 2.8 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Glyco_hydro_32N PF00251.20 AAS53900.1 - 1.5e-89 300.6 9.2 2e-89 300.2 9.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 N-terminal domain Glyco_hydro_32C PF08244.12 AAS53900.1 - 9.1e-15 55.0 0.4 1.7e-14 54.1 0.4 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal DUF2724 PF10893.8 AAS53900.1 - 0.14 12.0 0.6 3.3 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2724) Glyco_hydro_76 PF03663.14 AAS53901.2 - 2.5e-146 487.9 9.4 2.9e-146 487.7 9.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 zf-C2H2_4 PF13894.6 AAS53902.1 - 8.6e-05 23.1 17.3 0.0092 16.8 1.7 4.3 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS53902.1 - 0.0031 17.9 2.8 0.0031 17.9 2.8 3.8 3 1 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS53902.1 - 0.045 14.2 1.3 0.045 14.2 1.3 3.6 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2HE PF16278.5 AAS53902.1 - 0.089 13.3 0.3 25 5.4 0.0 3.3 3 0 0 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger Leader_CPA1 PF08252.11 AAS53904.1 - 2.9e-16 58.5 8.1 3.1e-16 58.4 8.1 1.0 1 0 0 1 1 1 1 arg-2/CPA1 leader peptide CPSase_sm_chain PF00988.22 AAS53905.1 - 1.8e-43 147.4 0.0 3e-43 146.7 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 AAS53905.1 - 4.9e-43 147.1 0.0 6.6e-43 146.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AAS53905.1 - 5.1e-05 23.1 0.5 0.00068 19.4 0.1 2.6 1 1 0 2 2 2 1 Peptidase C26 RCC1 PF00415.18 AAS53907.2 - 4.8e-13 49.5 0.3 3.4e-06 27.6 0.0 3.4 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat BTB PF00651.31 AAS53907.2 - 8.8e-09 35.6 0.1 1.3e-07 31.8 0.2 2.4 2 0 0 2 2 2 1 BTB/POZ domain RCC1_2 PF13540.6 AAS53907.2 - 9.7e-07 28.4 10.3 0.0041 16.9 0.0 4.0 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat Ank_4 PF13637.6 AAS53907.2 - 0.0013 19.3 0.0 0.02 15.4 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (many copies) SNF2_N PF00176.23 AAS53908.1 - 4e-73 246.1 1.4 7.1e-73 245.3 1.4 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain SLIDE PF09111.10 AAS53908.1 - 6.8e-39 132.4 2.2 6.8e-39 132.4 2.2 2.3 2 0 0 2 2 2 1 SLIDE HAND PF09110.11 AAS53908.1 - 1.8e-33 115.6 3.1 1.8e-33 115.6 3.1 2.9 2 0 0 2 2 2 1 HAND Helicase_C PF00271.31 AAS53908.1 - 2.1e-20 73.1 0.1 4.2e-19 68.9 0.0 2.8 2 1 1 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS53908.1 - 2.9e-12 46.9 0.4 3.8e-11 43.3 0.0 2.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS53908.1 - 5.1e-06 25.9 0.1 0.00023 20.4 0.0 2.7 1 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 AAS53908.1 - 1.4e-05 25.2 0.0 0.0037 17.4 0.0 2.8 2 0 0 2 2 2 1 Myb-like DNA-binding domain ERCC3_RAD25_C PF16203.5 AAS53908.1 - 0.00021 20.6 0.2 0.0006 19.1 0.2 1.7 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DEAD PF00270.29 AAS53908.1 - 0.00037 20.3 0.2 0.0022 17.8 0.0 2.4 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_14 PF13173.6 AAS53908.1 - 0.034 14.2 0.1 0.18 11.8 0.1 2.3 1 0 0 1 1 1 0 AAA domain DEAD_2 PF06733.15 AAS53908.1 - 0.079 12.6 0.1 0.28 10.8 0.1 1.9 1 0 0 1 1 1 0 DEAD_2 Condensin2nSMC PF12422.8 AAS53908.1 - 0.2 11.8 0.9 2.2 8.4 0.2 2.5 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit RNase_3_N PF18497.1 AAS53909.2 - 1.4e-37 128.1 0.0 2.7e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 Ribonuclease III N-terminal domain Ribonuclease_3 PF00636.26 AAS53909.2 - 1.5e-16 60.9 0.0 4.6e-16 59.3 0.0 1.9 2 0 0 2 2 2 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 AAS53909.2 - 8.9e-15 55.0 0.0 2.1e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease-III-like dsrm PF00035.26 AAS53909.2 - 0.00094 19.8 0.0 0.0026 18.4 0.0 1.8 1 0 0 1 1 1 1 Double-stranded RNA binding motif DUF382 PF04037.13 AAS53910.1 - 4.1e-55 185.3 0.1 6.9e-55 184.6 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF382) PSP PF04046.16 AAS53910.1 - 1.1e-17 63.6 0.5 2.2e-17 62.6 0.5 1.6 1 0 0 1 1 1 1 PSP DUF2573 PF10835.8 AAS53911.1 - 0.024 15.0 0.1 0.029 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2573) XhlA PF10779.9 AAS53911.1 - 0.037 14.2 1.5 0.037 14.2 1.5 1.5 2 0 0 2 2 2 0 Haemolysin XhlA DUF1664 PF07889.12 AAS53911.1 - 0.14 12.2 1.1 0.16 12.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF2034 PF10356.9 AAS53912.1 - 5.7e-61 205.2 0.0 6.7e-61 204.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2034) Mrr_cat PF04471.12 AAS53912.1 - 0.075 13.1 0.0 13 5.9 0.0 2.2 2 0 0 2 2 2 0 Restriction endonuclease Mito_carr PF00153.27 AAS53913.1 - 1.1e-25 89.4 2.3 1.5e-11 44.0 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein TPT PF03151.16 AAS53914.1 - 1.1e-29 103.7 15.4 1.3e-28 100.2 15.4 2.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 AAS53914.1 - 4.5e-06 26.9 26.7 0.00038 20.6 0.2 3.6 3 1 0 3 3 3 3 EamA-like transporter family UAA PF08449.11 AAS53914.1 - 0.01 15.1 1.7 0.01 15.1 1.7 2.8 2 1 1 3 3 3 0 UAA transporter family SIS PF01380.22 AAS53915.1 - 1.5e-16 60.4 0.0 2.4e-16 59.8 0.0 1.3 1 0 0 1 1 1 1 SIS domain SIS_2 PF13580.6 AAS53915.1 - 0.068 13.2 0.0 7.4 6.6 0.0 2.7 1 1 1 2 2 2 0 SIS domain SKN1 PF03935.15 AAS53916.1 - 6.6e-253 839.6 2.0 7.7e-253 839.4 2.0 1.0 1 0 0 1 1 1 1 Beta-glucan synthesis-associated protein (SKN1) MCM PF00493.23 AAS53917.1 - 8.8e-104 345.5 0.5 1.3e-103 344.9 0.5 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AAS53917.1 - 4.1e-39 133.3 0.1 8.3e-39 132.3 0.1 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AAS53917.1 - 5.4e-27 94.0 1.5 1.2e-26 92.9 1.5 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 AAS53917.1 - 2.4e-26 92.1 1.8 2.4e-26 92.1 1.8 1.9 2 0 0 2 2 2 1 MCM6 C-terminal winged-helix domain MCM_N PF14551.6 AAS53917.1 - 8.2e-24 84.2 0.2 3.4e-23 82.2 0.0 2.2 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 AAS53917.1 - 2.4e-07 30.4 0.0 1.2e-06 28.1 0.0 2.1 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 AAS53917.1 - 0.0044 16.8 0.0 0.0089 15.7 0.0 1.5 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_3 PF07726.11 AAS53917.1 - 0.0046 16.8 0.0 0.011 15.6 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AAS53917.1 - 0.0054 16.7 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Phosphorylase PF00343.20 AAS53918.1 - 0 1030.7 0.0 0 1030.5 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate phosphorylase Aminotran_1_2 PF00155.21 AAS53919.1 - 4.4e-20 72.2 0.0 5.4e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 AAS53919.1 - 0.0057 16.0 0.0 0.011 15.1 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Peptidase_S10 PF00450.22 AAS53920.1 - 3.5e-93 313.3 0.0 4.5e-93 312.9 0.0 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase UCH PF00443.29 AAS53922.2 - 1.4e-49 168.9 1.5 1.7e-49 168.6 1.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS53922.2 - 3.5e-15 56.4 6.3 3.5e-15 56.4 6.3 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AAS53922.2 - 1.6e-12 47.6 8.7 1.6e-12 47.6 8.7 2.9 2 1 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein Phosducin PF02114.16 AAS53923.2 - 1.7e-15 56.7 1.2 2.2e-15 56.3 1.2 1.1 1 0 0 1 1 1 1 Phosducin MRC1 PF09444.10 AAS53923.2 - 0.017 15.6 2.2 0.017 15.6 2.2 2.4 2 1 1 3 3 3 0 MRC1-like domain dsDNA_bind PF01984.20 AAS53923.2 - 0.022 15.0 0.9 0.18 12.1 0.1 2.3 2 0 0 2 2 2 0 Double-stranded DNA-binding domain Mre11_DNA_bind PF04152.14 AAS53924.1 - 3.3e-50 170.7 0.1 8.7e-50 169.3 0.1 1.7 1 0 0 1 1 1 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 AAS53924.1 - 4.4e-14 53.4 0.6 7.9e-14 52.6 0.6 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase His_Phos_1 PF00300.22 AAS53925.1 - 3.6e-44 150.8 5.0 4.5e-44 150.5 5.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) RNaseH_pPIWI_RE PF13032.6 AAS53925.1 - 0.005 16.8 0.2 0.0078 16.1 0.0 1.4 2 0 0 2 2 2 1 RNaseH domain of pPIWI_RE Rhodanese PF00581.20 AAS53926.1 - 2e-16 60.5 0.0 2.6e-16 60.1 0.0 1.2 1 0 0 1 1 1 1 Rhodanese-like domain SUKH-4 PF14435.6 AAS53926.1 - 0.018 15.1 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 SUKH-4 immunity protein Rhodanese PF00581.20 AAS53927.1 - 1.6e-12 47.9 0.0 1.9e-12 47.7 0.0 1.1 1 0 0 1 1 1 1 Rhodanese-like domain VHP PF02209.19 AAS53927.1 - 0.025 14.7 0.1 0.052 13.6 0.1 1.5 1 0 0 1 1 1 0 Villin headpiece domain DAO_C PF16901.5 AAS53927.1 - 0.15 12.0 0.0 1.9 8.4 0.0 2.0 2 0 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase RRP36 PF06102.12 AAS53928.1 - 2.7e-40 138.1 25.1 2.7e-40 138.1 25.1 2.0 2 0 0 2 2 2 1 rRNA biogenesis protein RRP36 Rx_N PF18052.1 AAS53928.1 - 0.024 14.9 2.4 0.024 14.9 2.4 2.2 2 0 0 2 2 2 0 Rx N-terminal domain Matrilin_ccoil PF10393.9 AAS53928.1 - 0.04 13.8 2.3 0.04 13.8 2.3 1.9 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin USP8_interact PF08941.10 AAS53928.1 - 2.2 8.1 6.8 6.5 6.5 1.8 1.9 1 1 1 2 2 2 0 USP8 interacting MRP_L53 PF10780.9 AAS53929.1 - 8.8e-19 67.4 0.7 1.2e-18 67.0 0.7 1.2 1 0 0 1 1 1 1 39S ribosomal protein L53/MRP-L53 Thioredoxin PF00085.20 AAS53930.2 - 4.9e-23 81.1 0.0 1.3e-22 79.7 0.0 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AAS53930.2 - 1.3e-05 25.6 0.1 4.5e-05 23.8 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AAS53930.2 - 2.7e-05 24.3 0.1 6.3e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_8 PF13905.6 AAS53930.2 - 0.046 14.0 0.0 0.18 12.1 0.0 1.9 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_6 PF13848.6 AAS53930.2 - 0.099 12.5 0.0 4.2 7.3 0.0 2.6 2 1 1 3 3 3 0 Thioredoxin-like domain TraF PF13728.6 AAS53930.2 - 0.12 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein AMMECR1 PF01871.17 AAS53931.1 - 3.1e-38 131.0 0.0 3.7e-38 130.8 0.0 1.1 1 0 0 1 1 1 1 AMMECR1 adh_short PF00106.25 AAS53932.1 - 1.9e-55 187.4 0.2 1.9e-55 187.4 0.2 1.4 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS53932.1 - 2e-37 129.0 0.3 2.7e-37 128.6 0.3 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS53932.1 - 8.4e-15 55.1 0.0 1.3e-14 54.5 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AAS53932.1 - 0.00011 21.7 0.0 0.00091 18.7 0.0 1.9 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) Polysacc_synt_2 PF02719.15 AAS53932.1 - 0.0011 18.2 0.3 0.0021 17.3 0.3 1.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein Epimerase PF01370.21 AAS53932.1 - 0.0067 15.9 0.2 0.012 15.1 0.2 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.8 AAS53932.1 - 0.031 14.0 0.2 0.071 12.9 0.2 1.6 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase SNF2_N PF00176.23 AAS53933.2 - 1.4e-69 234.4 0.1 4e-69 233.0 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS53933.2 - 3.6e-21 75.6 0.2 1.7e-19 70.2 0.0 2.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SnAC PF14619.6 AAS53933.2 - 6.6e-16 58.7 1.6 6.6e-16 58.7 1.6 3.8 4 0 0 4 4 4 1 Snf2-ATP coupling, chromatin remodelling complex Bromodomain PF00439.25 AAS53933.2 - 9.5e-14 51.2 0.3 4.4e-13 49.1 0.3 2.2 1 0 0 1 1 1 1 Bromodomain QLQ PF08880.11 AAS53933.2 - 5.6e-11 42.0 0.5 5.6e-11 42.0 0.5 2.5 2 0 0 2 2 2 1 QLQ ResIII PF04851.15 AAS53933.2 - 5.5e-08 33.0 1.8 2.1e-07 31.1 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HSA PF07529.13 AAS53933.2 - 1.6e-06 28.4 9.8 1.6e-06 28.4 9.8 2.9 3 0 0 3 3 3 1 HSA TAFII55_N PF04658.13 AAS53934.1 - 6.8e-51 172.2 0.0 1.5e-50 171.1 0.0 1.6 1 0 0 1 1 1 1 TAFII55 protein conserved region NOA36 PF06524.12 AAS53934.1 - 0.55 9.5 35.0 0.34 10.2 15.8 2.2 2 0 0 2 2 2 0 NOA36 protein Cwf_Cwc_15 PF04889.12 AAS53934.1 - 1.9 8.2 37.0 4.4 7.0 14.8 2.6 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RrnaAD PF00398.20 AAS53935.2 - 5.5e-49 166.6 0.0 6.9e-49 166.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase UCR_UQCRX_QCR9 PF05365.12 AAS53936.1 - 0.2 11.6 0.2 3.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like SpvD PF05563.12 AAS53936.1 - 0.2 11.2 0.0 0.31 10.6 0.0 1.2 1 0 0 1 1 1 0 Salmonella plasmid virulence protein SpvD S1 PF00575.23 AAS53937.2 - 1.8e-46 156.4 27.2 2.8e-10 40.4 0.2 12.4 12 1 0 12 12 12 8 S1 RNA binding domain TPR_19 PF14559.6 AAS53937.2 - 8.4e-08 32.6 0.2 0.46 11.0 0.0 3.5 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 AAS53937.2 - 1.6e-06 28.4 9.7 0.53 11.3 0.1 5.4 2 1 4 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS53937.2 - 3e-05 24.6 1.4 0.17 12.5 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat Suf PF05843.14 AAS53937.2 - 8.8e-05 22.6 0.1 0.00029 20.9 0.0 3.4 2 1 2 4 4 3 3 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 AAS53937.2 - 0.0003 20.0 3.1 0.02 14.0 0.4 3.1 1 1 2 3 3 3 1 NRDE-2, necessary for RNA interference Pfg27 PF09216.10 AAS53937.2 - 0.011 15.6 3.1 2.7 7.8 0.0 2.9 3 0 0 3 3 3 0 Pfg27 RNA_pol_Rbc25 PF08292.12 AAS53937.2 - 0.019 15.2 0.4 0.53 10.5 0.0 3.8 3 1 1 4 4 4 0 RNA polymerase III subunit Rpc25 IRK_C PF17655.1 AAS53937.2 - 0.13 11.8 0.3 1.7 8.2 0.0 2.4 2 0 0 2 2 2 0 Inward rectifier potassium channel C-terminal domain ProQ_C PF17516.2 AAS53937.2 - 0.7 9.4 5.1 0.71 9.3 1.4 2.8 2 0 0 2 2 2 0 ProQ C-terminal domain TPR_2 PF07719.17 AAS53937.2 - 2.3 8.6 6.7 27 5.2 0.0 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat P5-ATPase PF12409.8 AAS53938.2 - 4.6e-35 120.4 1.2 1.1e-34 119.3 1.2 1.7 1 0 0 1 1 1 1 P5-type ATPase cation transporter E1-E2_ATPase PF00122.20 AAS53938.2 - 1.2e-31 109.7 0.5 2.3e-31 108.7 0.0 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AAS53938.2 - 3e-15 57.1 0.1 6.5e-06 26.6 0.0 3.2 3 0 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS53938.2 - 8.1e-07 29.0 0.0 1.6e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_C PF00689.21 AAS53938.2 - 0.0041 16.8 4.8 0.0041 16.8 4.8 2.5 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Cation_ATPase_N PF00690.26 AAS53938.2 - 0.049 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AAS53938.2 - 0.082 12.6 0.0 3.1 7.4 0.0 2.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Mpv17_PMP22 PF04117.12 AAS53939.2 - 8.5e-18 64.4 1.1 1.9e-17 63.3 1.1 1.6 1 0 0 1 1 1 1 Mpv17 / PMP22 family DUF962 PF06127.11 AAS53939.2 - 0.068 13.3 0.0 0.3 11.2 0.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF962) S10_plectin PF03501.15 AAS53940.1 - 1.7e-41 140.2 0.1 1.9e-41 140.0 0.1 1.0 1 0 0 1 1 1 1 Plectin/S10 domain DUF4364 PF14277.6 AAS53940.1 - 0.027 14.2 0.1 0.035 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) RQC PF09382.10 AAS53940.1 - 0.1 12.4 0.1 0.44 10.3 0.0 1.9 1 1 1 2 2 2 0 RQC domain EF-hand_7 PF13499.6 AAS53941.1 - 5.7e-07 29.9 3.8 0.00013 22.3 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 AAS53941.1 - 0.00013 21.6 2.6 0.95 9.6 0.1 3.8 4 0 0 4 4 4 2 EF-hand domain GRP PF07172.11 AAS53941.1 - 1.8 9.3 19.5 4.1 8.1 19.5 1.5 1 0 0 1 1 1 0 Glycine rich protein family Septin PF00735.18 AAS53942.2 - 1e-97 326.8 0.0 1.7e-97 326.1 0.0 1.3 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 AAS53942.2 - 7.8e-07 29.2 0.0 2e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS53942.2 - 6.7e-05 22.9 0.3 0.00042 20.3 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 AAS53942.2 - 0.00014 22.0 0.1 0.16 12.0 0.1 2.9 1 1 1 2 2 2 2 Dynamin family AIG1 PF04548.16 AAS53942.2 - 0.00087 18.7 0.2 0.0069 15.7 0.1 2.3 2 0 0 2 2 2 1 AIG1 family AAA_16 PF13191.6 AAS53942.2 - 0.0085 16.5 0.2 0.021 15.2 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 AAS53942.2 - 0.016 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 AAS53942.2 - 0.036 13.4 0.0 0.07 12.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_24 PF13479.6 AAS53942.2 - 0.068 12.9 0.6 0.27 10.9 0.0 2.2 3 0 0 3 3 3 0 AAA domain DUF87 PF01935.17 AAS53942.2 - 1 9.4 0.0 1 9.4 0.0 2.6 3 0 0 3 3 3 0 Helicase HerA, central domain ABC_tran PF00005.27 AAS53942.2 - 9.4 6.8 7.2 0.51 10.8 0.2 2.4 3 1 0 3 3 3 0 ABC transporter FA_hydroxylase PF04116.13 AAS53943.1 - 2.4e-26 92.6 20.2 2.4e-26 92.6 20.2 2.2 2 1 1 3 3 3 1 Fatty acid hydroxylase superfamily GATase_5 PF13507.6 AAS53944.1 - 1.2e-100 336.0 0.0 1.8e-100 335.4 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain AIRS_C PF02769.22 AAS53944.1 - 1.4e-45 155.2 0.4 3e-31 108.7 0.1 2.4 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain FGAR-AT_N PF18076.1 AAS53944.1 - 1.1e-26 93.1 0.0 2.1e-26 92.2 0.0 1.5 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase N-terminal FGAR-AT_linker PF18072.1 AAS53944.1 - 1.5e-21 76.7 0.0 5.4e-21 74.9 0.0 2.1 2 0 0 2 2 2 1 Formylglycinamide ribonucleotide amidotransferase linker domain DUF2462 PF09495.10 AAS53945.1 - 2.1e-14 54.0 14.5 2.8e-14 53.6 14.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2462) ECH_2 PF16113.5 AAS53945.1 - 0.14 11.6 1.5 0.14 11.6 1.5 1.0 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase 60KD_IMP PF02096.20 AAS53946.1 - 2.1e-06 27.8 1.9 3.8e-06 26.9 0.4 1.8 2 0 0 2 2 2 1 60Kd inner membrane protein Spt4 PF06093.13 AAS53947.1 - 9.4e-29 99.3 0.5 1.1e-28 99.1 0.5 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger zf-TFIIB PF13453.6 AAS53947.1 - 0.057 12.8 0.8 0.12 11.8 0.8 1.5 1 0 0 1 1 1 0 Transcription factor zinc-finger Glutaredoxin PF00462.24 AAS53948.1 - 1.9e-05 24.8 0.0 5.8e-05 23.2 0.0 1.9 2 1 0 2 2 2 1 Glutaredoxin DUF953 PF06110.11 AAS53948.1 - 0.0013 18.3 0.2 0.0018 17.9 0.2 1.3 1 1 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 AAS53948.1 - 0.01 15.6 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin MFS_1 PF07690.16 AAS53949.2 - 5e-20 71.7 24.4 5e-20 71.7 24.4 1.8 1 1 0 2 2 2 1 Major Facilitator Superfamily Ribosomal_S8 PF00410.19 AAS53950.1 - 9.5e-24 83.8 0.1 1.5e-23 83.1 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein S8 zf-C2H2 PF00096.26 AAS53951.1 - 4.9e-07 29.9 12.9 4e-05 23.8 2.5 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS53951.1 - 9.4e-05 22.9 12.1 0.011 16.5 2.2 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS53951.1 - 0.00022 21.5 5.4 0.00022 21.5 5.4 3.4 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS53951.1 - 6.2 7.2 7.3 5.7 7.4 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Arrestin_C PF02752.22 AAS53952.2 - 9.9e-14 51.9 0.0 1.5e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 AAS53952.2 - 0.0014 18.7 0.0 0.061 13.4 0.0 2.3 2 0 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain Maf_N PF08383.11 AAS53952.2 - 0.069 12.9 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 Maf N-terminal region F-box PF00646.33 AAS53953.1 - 1.2e-05 25.1 2.6 1.3e-05 24.9 0.5 2.2 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 AAS53953.1 - 0.0006 19.6 0.7 0.0006 19.6 0.7 2.3 2 0 0 2 2 2 1 F-box-like DUF1891 PF09004.10 AAS53953.1 - 0.19 11.3 0.4 0.49 10.0 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1891) HSP70 PF00012.20 AAS53954.1 - 2.5e-212 706.3 8.1 3.1e-212 706.0 8.1 1.0 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 AAS53954.1 - 1.2e-16 60.4 2.6 4.5e-14 52.0 0.9 2.4 2 0 0 2 2 2 2 MreB/Mbl protein FGGY_C PF02782.16 AAS53954.1 - 7.2e-05 22.6 0.0 0.00015 21.5 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Uso1_p115_C PF04871.13 AAS53954.1 - 1.4 9.3 4.1 0.45 10.9 0.5 1.9 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region P21-Arc PF04062.14 AAS53955.1 - 3.8e-70 235.5 0.0 4.2e-70 235.3 0.0 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit CNH PF00780.22 AAS53956.2 - 2e-83 280.2 0.2 4.2e-83 279.1 0.1 1.6 2 0 0 2 2 2 1 CNH domain PH_5 PF15405.6 AAS53956.2 - 8.1e-37 126.3 0.0 1.9e-36 125.1 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain RhoGEF PF00621.20 AAS53956.2 - 1.9e-30 106.4 0.7 3.8e-30 105.5 0.1 1.9 2 0 0 2 2 2 1 RhoGEF domain DEP PF00610.21 AAS53956.2 - 4.1e-15 55.6 0.0 9e-15 54.5 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ELO PF01151.18 AAS53957.1 - 6.3e-62 209.4 20.0 7.6e-62 209.1 20.0 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family zf-BED PF02892.15 AAS53958.1 - 0.00095 19.1 8.7 0.0023 17.9 8.7 1.7 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.6 AAS53959.1 - 7e-06 26.5 28.2 0.00027 21.5 1.6 4.9 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AAS53959.1 - 0.00016 21.6 1.4 0.00016 21.6 1.4 3.8 3 1 0 3 3 3 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AAS53959.1 - 0.00052 20.3 2.8 0.00052 20.3 2.8 5.0 4 1 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 AAS53959.1 - 0.0044 17.3 0.1 0.0044 17.3 0.1 3.8 4 0 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 AAS53959.1 - 0.06 13.8 0.8 0.06 13.8 0.8 5.3 4 1 1 5 5 5 0 Zinc-finger double domain zf-SNAP50_C PF12251.8 AAS53959.1 - 0.17 11.5 7.4 0.29 10.8 1.7 2.1 2 0 0 2 2 2 0 snRNA-activating protein of 50kDa MW C terminal zf-C2HC_2 PF13913.6 AAS53959.1 - 3 7.8 11.5 0.38 10.7 1.3 3.2 3 0 0 3 3 3 0 zinc-finger of a C2HC-type zf-Di19 PF05605.12 AAS53959.1 - 4.2 7.7 9.0 6.6 7.1 5.0 3.1 3 1 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding FA_desaturase PF00487.24 AAS53960.1 - 5.2e-23 82.2 19.9 7.9e-23 81.6 19.9 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF3474 PF11960.8 AAS53960.1 - 2.2e-05 24.7 0.0 4.3e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3474) KRE9 PF05390.11 AAS53961.2 - 2.9e-39 133.9 4.3 5.4e-39 133.1 4.3 1.4 1 0 0 1 1 1 1 Yeast cell wall synthesis protein KRE9/KNH1 GPI-anchored PF10342.9 AAS53961.2 - 5.7e-12 46.2 0.0 1.3e-11 45.1 0.0 1.7 1 0 0 1 1 1 1 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family La PF05383.17 AAS53962.2 - 1.7e-21 76.0 0.0 3.3e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 La domain BRAP2 PF07576.12 AAS53962.2 - 0.073 13.3 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 BRCA1-associated protein 2 Acyltransferase PF01553.21 AAS53963.2 - 2.5e-32 111.3 0.0 5.6e-32 110.2 0.0 1.5 1 1 0 1 1 1 1 Acyltransferase FIVAR PF07554.13 AAS53963.2 - 0.23 12.2 0.9 0.43 11.4 0.9 1.3 1 0 0 1 1 1 0 FIVAR domain FBPase PF00316.20 AAS53964.2 - 1.7e-81 272.3 0.6 2.2e-81 271.9 0.6 1.1 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 AAS53964.2 - 0.16 11.5 0.0 0.27 10.7 0.0 1.3 1 0 0 1 1 1 0 Inositol monophosphatase family MFS_1 PF07690.16 AAS53966.1 - 5.3e-06 25.6 56.8 3.7e-05 22.8 26.8 2.6 1 1 1 2 2 2 2 Major Facilitator Superfamily SecY PF00344.20 AAS53967.1 - 7.4e-63 212.6 10.0 9.2e-63 212.3 10.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AAS53967.1 - 1e-16 60.5 0.2 3.9e-16 58.6 0.2 2.1 1 0 0 1 1 1 1 Plug domain of Sec61p SdpI PF13630.6 AAS53967.1 - 0.066 13.3 0.5 0.066 13.3 0.5 2.5 4 0 0 4 4 4 0 SdpI/YhfL protein family Glyco_hydro_85 PF03644.13 AAS53968.2 - 6.7e-64 216.2 1.7 6.7e-64 216.2 1.7 1.6 2 0 0 2 2 2 1 Glycosyl hydrolase family 85 Transp_cyt_pur PF02133.15 AAS53969.2 - 2.8e-152 507.5 33.7 3.3e-152 507.3 33.7 1.1 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin Cys_rich_CPCC PF14206.6 AAS53969.2 - 0.087 12.7 0.0 0.23 11.3 0.0 1.7 1 0 0 1 1 1 0 Cysteine-rich CPCC Phage_holin_Dp1 PF16938.5 AAS53969.2 - 0.64 10.3 4.7 1.8 8.8 0.1 3.1 3 0 0 3 3 3 0 Putative phage holin Dp-1 NTP_transferase PF00483.23 AAS53970.1 - 2.2e-53 181.4 0.0 2.7e-53 181.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AAS53970.1 - 6.9e-11 42.8 0.0 9.1e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Hexapep PF00132.24 AAS53970.1 - 3.2e-09 36.1 7.4 1.5e-06 27.7 1.8 3.7 1 1 3 4 4 4 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 AAS53970.1 - 0.00018 19.8 0.4 0.00026 19.3 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 AAS53970.1 - 0.0053 15.7 0.2 0.023 13.6 0.2 1.8 2 0 0 2 2 2 1 L-fucokinase IspD PF01128.19 AAS53970.1 - 0.17 11.6 0.0 0.82 9.4 0.0 1.9 2 0 0 2 2 2 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Hexapep_2 PF14602.6 AAS53970.1 - 1.4 8.7 4.4 1.4 8.7 0.4 3.0 4 0 0 4 4 4 0 Hexapeptide repeat of succinyl-transferase Ank_4 PF13637.6 AAS53971.2 - 9.4e-13 48.4 0.1 5.5e-06 26.8 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 AAS53971.2 - 1.7e-12 47.7 0.0 3.2e-05 24.4 0.0 2.9 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 AAS53971.2 - 1.9e-09 37.5 0.1 0.14 12.6 0.0 4.0 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 AAS53971.2 - 4.9e-08 32.6 0.0 0.013 16.0 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat KilA-N PF04383.13 AAS53971.2 - 3.8e-07 29.9 0.4 2.7e-06 27.2 0.4 2.4 1 1 0 1 1 1 1 KilA-N domain Ank_5 PF13857.6 AAS53971.2 - 4.5e-05 23.7 0.2 0.048 14.0 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) 4HB_MCP_1 PF12729.7 AAS53971.2 - 0.057 13.0 4.5 0.11 12.0 4.5 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction DUF1664 PF07889.12 AAS53971.2 - 0.087 12.9 3.7 0.24 11.4 3.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) HBM PF16591.5 AAS53971.2 - 0.12 11.8 4.3 0.2 11.1 4.3 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain DUF2730 PF10805.8 AAS53971.2 - 0.3 11.2 3.6 0.78 9.9 3.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) FAM76 PF16046.5 AAS53971.2 - 1.1 8.6 4.3 2 7.7 4.3 1.5 1 0 0 1 1 1 0 FAM76 protein NPV_P10 PF05531.12 AAS53971.2 - 1.7 9.2 7.5 2.8 8.5 2.4 3.2 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Y_phosphatase3 PF13350.6 AAS53972.1 - 8.7e-57 192.7 0.0 1.3e-56 192.1 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Hydrolase_4 PF12146.8 AAS53972.1 - 2e-10 40.3 0.0 4.8e-09 35.8 0.0 2.3 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AAS53972.1 - 1.5e-07 31.4 0.0 0.00016 21.4 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AAS53972.1 - 1.2e-06 29.3 0.2 8.6e-06 26.5 0.2 2.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Sugar_tr PF00083.24 AAS53973.1 - 7.2e-112 374.5 30.3 8.4e-112 374.3 30.3 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS53973.1 - 3e-25 88.9 47.0 5.4e-22 78.2 26.2 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily SirB PF04247.12 AAS53973.1 - 0.17 12.0 13.2 0.79 9.8 1.5 3.0 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB DUF3681 PF12442.8 AAS53973.1 - 1.6 9.2 8.2 9.5 6.8 3.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3681) MutS_V PF00488.21 AAS53974.1 - 2.4e-84 282.1 0.2 5.5e-84 280.9 0.2 1.7 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 AAS53974.1 - 7.9e-31 107.8 0.5 7.9e-31 107.8 0.5 2.2 2 0 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 AAS53974.1 - 4e-17 62.3 0.4 4e-17 62.3 0.4 2.3 3 0 0 3 3 3 1 MutS family domain IV MutS_II PF05188.17 AAS53974.1 - 8.1e-17 61.8 0.1 2.7e-16 60.1 0.1 2.0 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 AAS53974.1 - 4.9e-09 36.4 0.0 2.1e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 MutS domain I AAA_27 PF13514.6 AAS53974.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain DASH_Dad2 PF08654.10 AAS53974.1 - 0.15 12.5 0.4 1.6 9.2 0.1 2.6 2 0 0 2 2 2 0 DASH complex subunit Dad2 Apt1 PF10351.9 AAS53974.1 - 0.16 10.8 1.9 0.43 9.4 1.1 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain Fez1 PF06818.15 AAS53975.2 - 0.0038 17.7 26.9 0.0038 17.7 26.9 3.5 3 2 0 3 3 3 1 Fez1 ADIP PF11559.8 AAS53975.2 - 0.016 15.3 45.5 0.1 12.7 7.6 4.8 3 1 0 4 4 4 0 Afadin- and alpha -actinin-Binding Musclin PF11037.8 AAS53975.2 - 0.19 11.6 3.8 0.18 11.7 0.3 2.7 2 0 0 2 2 2 0 Insulin-resistance promoting peptide in skeletal muscle SYCE1 PF15233.6 AAS53975.2 - 5.9 6.9 48.4 1.2 9.1 4.4 3.5 3 0 0 3 3 3 0 Synaptonemal complex central element protein 1 Med9 PF07544.13 AAS53975.2 - 9.5 6.4 34.4 0.17 12.0 10.7 4.8 3 1 1 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 PQ-loop PF04193.14 AAS53976.1 - 2.7e-42 142.3 16.7 2e-24 85.1 1.2 2.8 3 0 0 3 3 3 2 PQ loop repeat Bac_export_2 PF01312.19 AAS53976.1 - 0.2 10.8 0.9 0.34 10.1 0.1 1.7 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family MtN3_slv PF03083.16 AAS53976.1 - 0.44 10.6 5.9 0.37 10.9 0.3 2.7 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange WHIM1 PF15612.6 AAS53977.1 - 1e-06 28.1 0.1 2.6e-06 26.8 0.1 1.7 1 0 0 1 1 1 1 WSTF, HB1, Itc1p, MBD9 motif 1 PI-PLC-X PF00388.19 AAS53978.1 - 3.4e-12 46.2 0.0 4.9e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-specific phospholipase C, X domain WD40 PF00400.32 AAS53979.2 - 0.0018 19.0 0.7 2.2 9.3 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS53979.2 - 0.0087 16.3 0.0 8.3 6.8 0.0 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain BPL_LplA_LipB PF03099.19 AAS53980.1 - 0.00026 20.9 0.1 0.0016 18.4 0.1 2.1 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family DUF3419 PF11899.8 AAS53980.1 - 0.026 13.7 0.0 0.053 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3419) UPF0086 PF01868.16 AAS53981.1 - 1e-21 76.6 0.0 2.2e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function UPF0086 COMPASS-Shg1 PF05205.12 AAS53982.1 - 1.9e-19 70.2 0.0 2.4e-19 69.9 0.0 1.1 1 0 0 1 1 1 1 COMPASS (Complex proteins associated with Set1p) component shg1 SecY PF00344.20 AAS53984.1 - 1.4e-40 139.5 13.0 1.9e-40 139.0 13.0 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AAS53984.1 - 1.7e-09 37.4 0.1 4.4e-09 36.0 0.1 1.8 1 0 0 1 1 1 1 Plug domain of Sec61p DUF4231 PF14015.6 AAS53984.1 - 2.4 8.6 6.6 7.5 7.1 0.4 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4231) DUF1155 PF06633.11 AAS53984.1 - 4.9 6.7 5.6 29 4.2 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1155) AIM5 PF17050.5 AAS53985.1 - 4.1e-10 40.3 0.6 6.6e-10 39.7 0.6 1.3 1 0 0 1 1 1 1 Altered inheritance of mitochondria 5 RRF PF01765.19 AAS53985.1 - 0.0086 16.0 0.2 0.012 15.5 0.2 1.2 1 0 0 1 1 1 1 Ribosome recycling factor Methyltransf_PK PF05891.12 AAS53986.2 - 2.4e-89 298.6 0.0 2.7e-89 298.4 0.0 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 AAS53986.2 - 1.1e-08 35.6 0.0 3e-08 34.3 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS53986.2 - 3.4e-05 24.4 0.0 7.4e-05 23.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS53986.2 - 0.00036 20.4 0.0 0.00052 19.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS53986.2 - 0.063 14.0 0.0 0.13 13.0 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain DUF2288 PF10052.9 AAS53986.2 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2288) DUF4420 PF14390.6 AAS53986.2 - 0.16 11.2 0.0 1 8.6 0.0 1.9 2 0 0 2 2 2 0 Putative PD-(D/E)XK family member, (DUF4420) Methyltransf_2 PF00891.18 AAS53986.2 - 0.16 11.2 0.0 0.3 10.4 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain RhoGAP PF00620.27 AAS53987.2 - 1.8e-40 138.2 0.0 4.3e-40 137.0 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain FCH PF00611.23 AAS53987.2 - 1e-05 25.7 0.3 3.8e-05 23.9 0.3 2.1 1 1 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain MSV199 PF10553.9 AAS53987.2 - 3.1 8.1 5.9 8.2 6.7 1.2 2.5 2 0 0 2 2 2 0 MSV199 domain ERM PF00769.19 AAS53987.2 - 3.6 7.3 9.7 0.61 9.9 5.2 1.8 2 0 0 2 2 2 0 Ezrin/radixin/moesin family UPF0061 PF02696.14 AAS53988.1 - 0.022 13.5 0.9 0.055 12.2 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized ACR, YdiU/UPF0061 family MRP-L27 PF09809.9 AAS53989.1 - 1.1e-32 112.2 0.2 1.8e-32 111.5 0.2 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein L27 SOP4 PF17081.5 AAS53990.1 - 1.5e-89 299.0 0.0 1.9e-89 298.7 0.0 1.1 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein Beach PF02138.18 AAS53991.2 - 3.7e-117 390.6 0.0 7.2e-117 389.7 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 AAS53991.2 - 2e-09 37.4 0.0 5.2e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Laminin_G_3 PF13385.6 AAS53991.2 - 0.0036 17.5 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 AAS53991.2 - 0.11 13.4 0.7 5.9 7.9 0.1 3.4 2 0 0 2 2 2 0 WD domain, G-beta repeat Cdc6_C PF09079.11 AAS53992.1 - 3e-14 52.7 0.1 7.1e-14 51.5 0.1 1.7 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 AAS53992.1 - 1.8e-08 34.9 0.0 6.6e-08 33.1 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS53992.1 - 2.8e-08 34.1 0.0 9.7e-08 32.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AAS53992.1 - 2e-07 31.5 0.5 1e-06 29.2 0.1 2.4 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_11 PF13086.6 AAS53992.1 - 0.021 14.6 1.0 0.51 10.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_lid_10 PF17872.1 AAS53992.1 - 0.061 13.4 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 AAA lid domain AAA_19 PF13245.6 AAS53992.1 - 0.15 12.4 0.8 0.57 10.5 0.1 2.2 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.6 AAS53992.1 - 0.15 11.7 0.1 0.45 10.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain Xan_ur_permease PF00860.20 AAS53993.1 - 1.7e-58 198.2 33.5 2.8e-58 197.5 33.5 1.2 1 0 0 1 1 1 1 Permease family Myb_DNA-binding PF00249.31 AAS53994.2 - 2.2e-14 53.4 0.0 3.5e-07 30.3 0.0 2.7 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 AAS53994.2 - 7.5e-05 22.9 2.4 0.0047 17.1 0.1 3.1 3 0 0 3 3 3 2 Myb-like DNA-binding domain Ciart PF15673.5 AAS53994.2 - 0.34 10.3 6.1 0.046 13.1 1.3 1.9 2 0 0 2 2 2 0 Circadian-associated transcriptional repressor ELO PF01151.18 AAS53995.1 - 6.3e-61 206.1 22.9 8e-61 205.7 22.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family RNase_PH PF01138.21 AAS53996.2 - 2.2e-24 86.5 0.1 2e-23 83.4 0.1 2.1 1 1 0 1 1 1 1 3' exoribonuclease family, domain 1 PfkB PF00294.24 AAS53997.1 - 2.9e-49 168.0 5.5 4.6e-48 164.1 5.5 2.1 1 1 0 1 1 1 1 pfkB family carbohydrate kinase UCH PF00443.29 AAS53998.2 - 4.1e-79 265.7 0.3 4.1e-79 265.7 0.3 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS53998.2 - 8.2e-15 55.2 0.8 3.6e-06 26.8 0.0 3.3 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 AAS53998.2 - 5.6e-05 23.7 0.3 0.00031 21.3 0.1 2.4 2 0 0 2 2 2 1 DUSP domain DUF365 PF04033.12 AAS53998.2 - 0.0044 17.3 0.6 0.014 15.7 0.6 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF365) CW_binding_1 PF01473.20 AAS53998.2 - 0.015 15.6 2.2 0.044 14.1 2.2 1.9 1 0 0 1 1 1 0 Putative cell wall binding repeat HSA PF07529.13 AAS53998.2 - 0.56 10.6 2.6 1.6 9.1 2.6 1.8 1 0 0 1 1 1 0 HSA TF_Zn_Ribbon PF08271.12 AAS53998.2 - 1.6 8.3 3.3 4.9 6.8 0.3 2.7 2 0 0 2 2 2 0 TFIIB zinc-binding SPX PF03105.19 AAS53999.2 - 2e-54 186.0 12.8 8.4e-37 128.0 6.6 2.1 1 1 1 2 2 2 2 SPX domain Na_sulph_symp PF00939.19 AAS53999.2 - 4.6e-24 85.3 43.2 6.4e-24 84.8 43.2 1.1 1 0 0 1 1 1 1 Sodium:sulfate symporter transmembrane region CitMHS PF03600.16 AAS53999.2 - 3.7e-23 82.2 47.4 3.7e-23 82.2 47.4 1.6 1 1 0 1 1 1 1 Citrate transporter Aconitase PF00330.20 AAS54000.2 - 1.4e-148 495.7 0.0 1.8e-148 495.4 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AAS54000.2 - 9e-42 142.5 0.0 1.9e-41 141.5 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.13 AAS54000.2 - 0.11 11.2 0.0 0.29 9.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF521) RasGEF PF00617.19 AAS54001.2 - 1.2e-37 129.8 0.1 3.4e-37 128.3 0.1 1.8 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 AAS54001.2 - 1.3e-14 54.3 3.2 1.2e-13 51.2 0.3 2.9 2 0 0 2 2 2 1 RasGEF N-terminal motif SH3_1 PF00018.28 AAS54001.2 - 0.001 18.6 0.1 0.0023 17.5 0.1 1.6 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS54001.2 - 0.0054 16.6 0.0 0.014 15.2 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS54001.2 - 0.04 13.6 0.0 0.45 10.2 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain CALM_bind PF16025.5 AAS54001.2 - 0.11 13.0 1.5 0.28 11.7 1.5 1.7 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding CRAL_TRIO_2 PF13716.6 AAS54002.1 - 1.6e-30 106.1 0.8 2.7e-30 105.3 0.2 1.7 2 0 0 2 2 2 1 Divergent CRAL/TRIO domain RhoGAP PF00620.27 AAS54002.1 - 5.4e-08 32.8 0.2 2.5e-07 30.7 0.2 2.1 1 1 0 1 1 1 1 RhoGAP domain CoaE PF01121.20 AAS54002.1 - 0.054 13.2 0.0 0.098 12.3 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase RTC4 PF14474.6 AAS54003.2 - 1.2e-31 109.4 0.0 2.4e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 RTC4-like domain HSP20 PF00011.21 AAS54004.1 - 5.8e-09 36.0 0.0 7.9e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AAS54004.1 - 5.3e-05 22.7 0.0 9.7e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 HSP20-like domain found in ArsA WD40 PF00400.32 AAS54005.1 - 1.7e-07 31.8 5.7 0.00011 22.9 0.1 4.9 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54005.1 - 2.7e-05 24.4 0.2 4.9 7.5 0.0 4.9 1 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain HTH_Tnp_IS1 PF12759.7 AAS54005.1 - 0.14 11.8 0.0 1.3 8.7 0.0 2.3 2 0 0 2 2 2 0 InsA C-terminal domain Peptidase_C37 PF05416.12 AAS54005.1 - 0.15 10.5 2.9 4.9 5.6 0.0 2.9 2 1 1 3 3 3 0 Southampton virus-type processing peptidase MRP-L46 PF11788.8 AAS54006.1 - 3.2e-36 124.7 0.0 5.1e-36 124.0 0.0 1.3 1 0 0 1 1 1 1 39S mitochondrial ribosomal protein L46 DUF2535 PF10751.9 AAS54006.1 - 0.13 12.8 0.1 6.5 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2535) RRM_1 PF00076.22 AAS54007.2 - 3.2e-07 30.1 0.0 6.3e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CTD_bind PF04818.13 AAS54007.2 - 3.1e-05 24.7 0.0 9.3e-05 23.2 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase II-binding domain. RRM_7 PF16367.5 AAS54007.2 - 0.0014 18.7 0.0 0.014 15.5 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif CTK3 PF12243.8 AAS54007.2 - 0.0061 16.5 0.1 0.035 14.1 0.1 2.1 1 1 0 1 1 1 1 CTD kinase subunit gamma CTK3 RNA_bind PF08675.11 AAS54007.2 - 0.0071 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain Spo7_2_N PF15407.6 AAS54007.2 - 0.081 12.6 0.0 0.2 11.3 0.0 1.7 1 0 0 1 1 1 0 Sporulation protein family 7 Macoilin PF09726.9 AAS54007.2 - 0.16 10.5 10.2 0.2 10.2 10.2 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 AAS54007.2 - 1.8 7.2 12.3 2.7 6.7 12.3 1.2 1 0 0 1 1 1 0 Presenilin PRP38_assoc PF12871.7 AAS54007.2 - 7.6 7.2 15.9 18 6.0 15.9 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term AAA_23 PF13476.6 AAS54008.2 - 4.5e-38 131.8 0.6 4.5e-38 131.8 0.6 8.1 2 1 3 5 5 2 1 AAA domain Rad50_zn_hook PF04423.14 AAS54008.2 - 5.7e-17 61.3 3.3 5.7e-17 61.3 3.3 5.1 3 0 0 3 3 3 1 Rad50 zinc hook motif AAA_21 PF13304.6 AAS54008.2 - 1.3e-09 38.4 14.3 1.6e-05 24.9 0.1 4.7 4 2 1 5 5 5 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS54008.2 - 3.2e-08 33.3 0.1 3.2e-08 33.3 0.1 2.7 2 1 0 2 2 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AAS54008.2 - 1.8e-07 31.3 19.2 1.8e-07 31.3 19.2 5.3 1 1 2 4 4 2 2 AAA ATPase domain SbcCD_C PF13558.6 AAS54008.2 - 2.9e-06 27.4 0.0 8.5e-06 25.9 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 AAS54008.2 - 0.0045 16.7 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 AAS54008.2 - 0.007 15.1 126.8 0.0073 15.0 0.0 7.7 2 1 4 7 7 6 4 AAA domain NPV_P10 PF05531.12 AAS54008.2 - 0.015 15.7 0.4 0.015 15.7 0.4 9.1 6 4 4 10 10 10 0 Nucleopolyhedrovirus P10 protein ABC_tran PF00005.27 AAS54008.2 - 0.018 15.5 0.0 0.018 15.5 0.0 7.7 4 2 0 4 4 2 0 ABC transporter Spectrin PF00435.21 AAS54008.2 - 0.022 15.2 1.2 0.022 15.2 1.2 10.7 4 2 7 11 11 9 0 Spectrin repeat YabA PF06156.13 AAS54008.2 - 0.033 14.8 0.8 0.033 14.8 0.8 11.6 3 3 6 10 10 8 0 Initiation control protein YabA AAA_16 PF13191.6 AAS54008.2 - 0.047 14.1 0.0 0.047 14.1 0.0 4.0 4 1 0 4 4 4 0 AAA ATPase domain AAA_22 PF13401.6 AAS54008.2 - 0.098 12.9 7.4 0.97 9.7 0.0 5.0 4 0 0 4 4 4 0 AAA domain ERM PF00769.19 AAS54008.2 - 0.14 11.9 116.9 0.11 12.3 0.6 6.9 2 1 4 6 6 6 0 Ezrin/radixin/moesin family FUSC PF04632.12 AAS54008.2 - 0.32 9.5 25.6 0.051 12.1 0.6 4.1 2 1 3 5 5 5 0 Fusaric acid resistance protein family RNA_pol_I_A49 PF06870.12 AAS54009.1 - 2.6e-119 398.5 0.3 3e-119 398.3 0.3 1.0 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor EAF PF09816.9 AAS54009.1 - 0.084 13.3 0.1 0.19 12.2 0.1 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription elongation factor PhageMin_Tail PF10145.9 AAS54009.1 - 1.1 9.1 5.3 0.74 9.6 2.5 1.9 2 0 0 2 2 2 0 Phage-related minor tail protein zf-CSL PF05207.13 AAS54010.1 - 3.1e-20 71.6 0.1 4.3e-20 71.2 0.1 1.2 1 0 0 1 1 1 1 CSL zinc finger DnaJ PF00226.31 AAS54010.1 - 3.8e-16 58.9 0.0 5.4e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 DnaJ domain Zn_Tnp_IS1 PF03811.13 AAS54010.1 - 0.28 10.9 1.6 0.39 10.5 0.1 1.9 2 0 0 2 2 2 0 InsA N-terminal domain tRNA-synt_1e PF01406.19 AAS54011.2 - 3e-132 440.5 0.0 4.1e-132 440.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AAS54011.2 - 6.5e-08 31.7 0.4 3.5e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AAS54011.2 - 3.4e-05 22.3 0.0 6.7e-05 21.3 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1c PF00749.21 AAS54011.2 - 0.00048 19.1 0.8 0.011 14.7 0.0 2.4 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1f PF01921.18 AAS54011.2 - 0.092 11.6 0.1 0.31 9.9 0.0 1.8 3 0 0 3 3 3 0 tRNA synthetases class I (K) NAP PF00956.18 AAS54012.1 - 5e-05 22.6 0.5 0.0054 15.9 0.0 2.8 1 1 1 2 2 2 2 Nucleosome assembly protein (NAP) SUI1 PF01253.22 AAS54013.2 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 AAS54013.2 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Homeodomain PF00046.29 AAS54014.3 - 2.2e-16 59.4 2.0 2.9e-16 59.1 2.0 1.1 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 AAS54014.3 - 3.3e-06 26.9 0.8 5.7e-06 26.1 0.3 1.7 2 0 0 2 2 2 1 Homeobox KN domain YdaS_antitoxin PF15943.5 AAS54014.3 - 0.033 14.1 0.0 0.064 13.1 0.0 1.5 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT PaaX_C PF08223.11 AAS54015.3 - 0.063 13.6 0.1 0.091 13.0 0.1 1.3 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Arnt_C PF18583.1 AAS54015.3 - 0.14 11.8 0.3 0.24 11.0 0.3 1.4 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain Sec10 PF07393.11 AAS54016.3 - 2.1e-58 198.4 1.5 2.8e-58 198.0 1.5 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 FliS PF02561.14 AAS54016.3 - 0.02 15.2 0.7 2.2 8.6 0.1 3.4 3 0 0 3 3 3 0 Flagellar protein FliS PRP21_like_P PF12230.8 AAS54017.2 - 4.3e-34 118.3 16.8 3.2e-24 86.0 6.4 2.8 2 1 1 3 3 3 2 Pre-mRNA splicing factor PRP21 like protein Surp PF01805.20 AAS54017.2 - 2.6e-09 36.9 0.2 2.6e-09 36.9 0.2 2.2 2 0 0 2 2 2 1 Surp module P16-Arc PF04699.14 AAS54017.2 - 0.35 11.3 4.0 21 5.6 0.1 3.0 2 2 1 3 3 3 0 ARP2/3 complex 16 kDa subunit (p16-Arc) zf-CCHC PF00098.23 AAS54018.1 - 1.8e-48 160.5 53.8 9e-09 35.0 1.7 7.1 7 0 0 7 7 7 7 Zinc knuckle zf-CCHC_4 PF14392.6 AAS54018.1 - 2.4e-13 49.6 43.8 0.007 16.1 0.4 7.1 6 1 1 7 7 7 7 Zinc knuckle zf-CCHC_5 PF14787.6 AAS54018.1 - 2.2e-05 24.1 35.9 0.2 11.4 1.0 7.0 4 1 3 7 7 7 4 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 AAS54018.1 - 0.0023 17.9 42.2 4.2 7.4 0.6 7.1 2 2 5 7 7 7 7 Zinc knuckle zf-C2H2_10 PF16588.5 AAS54018.1 - 0.012 15.4 2.7 0.012 15.4 2.7 6.6 7 0 0 7 7 7 0 C2H2 zinc-finger Pterin_bind PF00809.22 AAS54019.2 - 5.6e-56 190.0 0.0 1.3e-54 185.5 0.0 2.3 1 1 0 1 1 1 1 Pterin binding enzyme HPPK PF01288.20 AAS54019.2 - 3.4e-34 117.7 0.0 6.4e-34 116.8 0.0 1.5 1 0 0 1 1 1 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) FolB PF02152.18 AAS54019.2 - 8.8e-33 113.2 0.0 1.5e-15 57.7 0.0 2.8 3 0 0 3 3 3 2 Dihydroneopterin aldolase FAD_binding_3 PF01494.19 AAS54020.1 - 2.4e-20 73.1 0.6 5.1e-09 35.8 0.0 3.1 3 0 0 3 3 3 3 FAD binding domain Lycopene_cycl PF05834.12 AAS54020.1 - 5.9e-07 28.9 0.1 0.0023 17.0 0.1 2.7 3 0 0 3 3 3 2 Lycopene cyclase protein Pyr_redox_2 PF07992.14 AAS54020.1 - 0.00012 21.4 0.0 0.0036 16.6 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AAS54020.1 - 0.0061 15.8 0.0 0.0097 15.2 0.0 1.3 1 0 0 1 1 1 1 Thi4 family Trp_halogenase PF04820.14 AAS54020.1 - 0.011 14.7 0.0 0.06 12.2 0.0 2.0 2 0 0 2 2 2 0 Tryptophan halogenase DAO PF01266.24 AAS54020.1 - 0.012 15.2 0.1 0.27 10.8 0.2 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 AAS54020.1 - 0.018 15.6 0.1 8.1 7.1 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AAS54020.1 - 0.071 12.2 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 AAS54020.1 - 0.073 13.0 0.0 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 AAS54020.1 - 0.085 13.1 0.1 0.2 11.9 0.1 1.6 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain SE PF08491.10 AAS54020.1 - 0.1 11.6 0.0 0.15 11.1 0.0 1.2 1 0 0 1 1 1 0 Squalene epoxidase Pyr_redox_3 PF13738.6 AAS54020.1 - 0.11 11.8 0.1 0.83 8.8 0.1 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase RRM_1 PF00076.22 AAS54021.1 - 1.1e-14 54.0 0.0 1.9e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro_isomerase PF00160.21 AAS54021.1 - 2.1e-08 34.6 0.0 3.2e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_5 PF13893.6 AAS54021.1 - 0.0029 17.2 0.0 0.0052 16.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Abhydrolase_1 PF00561.20 AAS54022.1 - 1.2e-06 28.4 0.1 3.2e-06 27.0 0.1 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold PGAP1 PF07819.13 AAS54022.1 - 8.1e-06 25.7 0.0 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 PGAP1-like protein DUF676 PF05057.14 AAS54022.1 - 1.4e-05 24.7 0.0 2.5e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF915 PF06028.11 AAS54022.1 - 0.00017 21.0 0.0 0.00098 18.5 0.0 2.1 3 0 0 3 3 3 1 Alpha/beta hydrolase of unknown function (DUF915) Palm_thioest PF02089.15 AAS54022.1 - 0.00048 20.0 0.0 0.0016 18.4 0.0 1.9 1 1 0 1 1 1 1 Palmitoyl protein thioesterase Abhydrolase_6 PF12697.7 AAS54022.1 - 0.0035 18.0 0.0 0.0073 16.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family LCAT PF02450.15 AAS54022.1 - 0.0092 15.2 0.0 0.014 14.6 0.0 1.2 1 0 0 1 1 1 1 Lecithin:cholesterol acyltransferase VASt PF16016.5 AAS54023.1 - 6e-18 65.7 0.1 1.8e-17 64.1 0.1 1.8 1 0 0 1 1 1 1 VAD1 Analog of StAR-related lipid transfer domain BAR_3 PF16746.5 AAS54023.1 - 3.1e-08 33.6 0.0 1e-07 31.9 0.0 1.9 2 0 0 2 2 2 1 BAR domain of APPL family PH PF00169.29 AAS54023.1 - 3.4e-08 34.0 0.1 1.4e-07 32.0 0.1 2.2 2 0 0 2 2 2 1 PH domain GRAM PF02893.20 AAS54023.1 - 0.086 12.7 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 GRAM domain Dsl1_N PF11988.8 AAS54024.1 - 1.1e-101 340.4 4.9 1.1e-101 340.4 4.9 1.9 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 N terminal Dsl1_C PF11989.8 AAS54024.1 - 1.1e-90 302.6 10.8 1.1e-90 302.6 10.8 2.0 2 0 0 2 2 2 1 Retrograde transport protein Dsl1 C terminal HMA PF00403.26 AAS54025.1 - 1.1e-09 38.6 0.2 1.4e-09 38.3 0.2 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF1364 PF07102.12 AAS54025.1 - 0.041 13.7 0.0 0.043 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1364) Yae1_N PF09811.9 AAS54026.1 - 4.1e-11 42.4 1.7 4.1e-11 42.4 1.7 1.8 2 0 0 2 2 2 1 Essential protein Yae1, N terminal GYF PF02213.16 AAS54027.2 - 9.5e-08 31.6 4.5 2.6e-07 30.2 4.5 1.8 1 0 0 1 1 1 1 GYF domain DUF1351 PF07083.11 AAS54027.2 - 0.0032 17.3 3.5 0.0073 16.1 3.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) ORC5_C PF14630.6 AAS54028.1 - 3.6e-58 197.4 0.5 4.5e-58 197.0 0.5 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 AAS54028.1 - 3.5e-10 40.5 0.0 6.9e-10 39.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 AAS54028.1 - 0.0037 17.2 0.2 0.018 15.0 0.0 2.1 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AAS54028.1 - 0.0043 17.1 0.4 0.13 12.3 0.0 2.8 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 AAS54028.1 - 0.022 15.0 0.0 0.08 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 AAS54028.1 - 0.026 14.9 0.0 0.063 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF1744 PF08490.12 AAS54029.2 - 1.5e-129 432.1 0.8 2.5e-129 431.4 0.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B_exo1 PF03104.19 AAS54029.2 - 7.2e-77 258.8 1.3 7.2e-77 258.8 1.3 2.2 2 1 0 2 2 2 1 DNA polymerase family B, exonuclease domain DNA_pol_B PF00136.21 AAS54029.2 - 6.3e-15 54.8 3.0 1.9e-13 50.0 3.0 2.9 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo2 PF10108.9 AAS54029.2 - 2.4e-07 30.7 0.3 1.5e-06 28.1 0.3 2.3 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AAS54029.2 - 6.6e-05 23.0 0.0 0.00042 20.3 0.0 2.5 1 0 0 1 1 1 1 RNase_H superfamily NAPRTase_C PF17956.1 AAS54029.2 - 0.026 15.0 0.4 0.3 11.5 0.0 2.6 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain YIF1 PF03878.15 AAS54030.1 - 5.5e-78 261.8 5.0 6.7e-78 261.5 5.0 1.1 1 0 0 1 1 1 1 YIF1 Yip1 PF04893.17 AAS54030.1 - 1e-05 25.3 0.8 1e-05 25.3 0.8 1.6 2 0 0 2 2 2 1 Yip1 domain DnaJ PF00226.31 AAS54031.1 - 9.6e-16 57.7 0.4 2e-15 56.7 0.4 1.6 1 0 0 1 1 1 1 DnaJ domain LPD7 PF18821.1 AAS54031.1 - 0.02 15.0 0.1 0.052 13.7 0.1 1.7 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 7 CRAL_TRIO PF00650.20 AAS54032.1 - 8.4e-36 123.1 0.0 1.4e-35 122.4 0.0 1.4 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_N PF03765.15 AAS54032.1 - 9.2e-18 64.2 2.7 2.2e-17 63.0 2.7 1.7 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain UBA_4 PF14555.6 AAS54032.1 - 0.037 13.8 0.0 0.08 12.8 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain CRAL_TRIO_2 PF13716.6 AAS54032.1 - 0.075 13.2 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain UBA PF00627.31 AAS54032.1 - 0.16 11.9 0.1 0.34 10.9 0.1 1.6 1 0 0 1 1 1 0 UBA/TS-N domain ArAE_2_N PF10337.9 AAS54033.1 - 1.7e-45 156.0 5.9 1.7e-45 156.0 5.9 3.1 3 0 0 3 3 3 1 Putative ER transporter, 6TM, N-terminal FUSC_2 PF13515.6 AAS54033.1 - 1.1e-13 51.5 12.4 1.1e-13 51.5 12.4 2.9 2 2 0 2 2 2 1 Fusaric acid resistance protein-like ALMT PF11744.8 AAS54033.1 - 0.00013 21.0 1.4 0.00013 21.0 1.4 2.6 2 0 0 2 2 2 1 Aluminium activated malate transporter ArAE_2 PF10334.9 AAS54033.1 - 0.079 12.8 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 GCP_N_terminal PF17681.1 AAS54033.1 - 0.079 12.6 0.2 0.3 10.7 0.0 1.9 2 0 0 2 2 2 0 Gamma tubulin complex component N-terminal Tmemb_14 PF03647.13 AAS54033.1 - 2.4 9.0 8.1 4.8 8.0 0.1 2.9 3 0 0 3 3 3 0 Transmembrane proteins 14C UFD1 PF03152.14 AAS54034.1 - 9.7e-70 233.5 0.0 1.3e-69 233.2 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 TPR_19 PF14559.6 AAS54035.2 - 2.6e-16 59.9 4.2 9.7e-05 22.8 0.0 7.4 6 2 2 8 8 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 AAS54035.2 - 8.1e-16 56.8 9.5 0.19 11.9 0.0 9.8 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54035.2 - 1.4e-13 50.9 5.0 0.031 14.6 0.0 6.9 6 2 1 7 7 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 AAS54035.2 - 4.3e-13 48.5 10.9 0.068 13.0 0.0 8.8 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54035.2 - 1.6e-12 46.5 8.9 0.13 12.5 0.0 9.8 10 0 0 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54035.2 - 4.8e-12 46.3 0.0 0.0023 18.6 0.1 6.8 8 0 0 8 8 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 AAS54035.2 - 9.1e-11 41.4 9.0 0.15 12.5 0.3 7.7 9 0 0 9 9 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 AAS54035.2 - 4e-08 33.4 6.9 0.032 14.9 0.0 7.2 9 0 0 9 9 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS54035.2 - 6.8e-08 32.6 12.2 0.055 13.7 0.0 5.9 4 2 3 7 7 7 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 AAS54035.2 - 9.6e-07 28.3 0.9 0.23 10.6 0.0 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 AAS54035.2 - 2.6e-06 27.0 2.1 0.029 14.1 0.5 4.7 4 1 1 5 5 5 2 TPR repeat TPR_14 PF13428.6 AAS54035.2 - 3.4e-06 27.4 1.5 18 6.5 0.0 7.3 4 2 5 9 9 8 0 Tetratricopeptide repeat TPR_9 PF13371.6 AAS54035.2 - 1e-05 25.6 0.0 0.05 13.7 0.0 4.3 4 1 1 5 5 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 AAS54035.2 - 3.1e-05 23.7 3.7 3.9 7.7 0.0 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 AAS54035.2 - 0.0021 18.4 2.6 4.2 7.8 0.0 5.4 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 AAS54035.2 - 0.0055 16.5 0.7 17 5.4 0.0 5.7 6 1 1 7 7 6 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AAS54035.2 - 0.0078 16.7 1.0 0.32 11.4 0.1 3.2 3 0 0 3 3 3 1 Alkyl sulfatase dimerisation ATP13 PF12921.7 AAS54035.2 - 0.13 12.1 2.4 6 6.8 0.1 4.3 4 0 0 4 4 4 0 Mitochondrial ATPase expression TPPII_N PF12583.8 AAS54035.2 - 1.6 9.3 8.1 13 6.4 0.0 3.5 4 0 0 4 4 3 0 Tripeptidyl peptidase II N terminal Ist1 PF03398.14 AAS54036.2 - 2.1e-57 193.6 2.6 2.1e-57 193.6 2.6 1.6 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway Tam41_Mmp37 PF09139.11 AAS54037.2 - 4.4e-92 309.0 4.2 2.3e-84 283.6 0.3 2.1 1 1 1 2 2 2 2 Phosphatidate cytidylyltransferase, mitochondrial PI3_PI4_kinase PF00454.27 AAS54038.2 - 4e-35 121.8 0.1 1.7e-34 119.8 0.1 2.0 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Pik1 PF11522.8 AAS54038.2 - 4.4e-21 74.6 3.4 5e-21 74.4 0.9 2.4 2 0 0 2 2 2 1 Yeast phosphatidylinositol-4-OH kinase Pik1 PI3Ka PF00613.20 AAS54038.2 - 3.7e-05 23.2 1.3 5.9e-05 22.6 0.2 1.9 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 AAS54038.2 - 0.026 13.9 0.0 0.052 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) AA_permease PF00324.21 AAS54039.2 - 1.1e-135 453.0 42.4 1.3e-135 452.7 42.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54039.2 - 3.7e-34 118.3 48.1 6.7e-34 117.4 48.0 1.4 1 1 0 1 1 1 1 Amino acid permease RhodobacterPufX PF11511.8 AAS54039.2 - 0.074 12.7 1.5 5.1 6.8 0.3 3.1 2 0 0 2 2 2 0 Intrinsic membrane protein PufX AA_permease PF00324.21 AAS54040.1 - 2.4e-135 451.8 47.4 2.9e-135 451.5 47.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54040.1 - 2e-29 102.7 54.5 4.4e-29 101.6 52.8 1.8 1 1 0 1 1 1 1 Amino acid permease DUF2101 PF09874.9 AAS54040.1 - 0.0025 17.6 1.7 0.0025 17.6 1.7 2.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2101) FH2 PF02181.23 AAS54041.2 - 4.6e-88 295.9 10.5 4.6e-88 295.9 10.5 2.9 3 0 0 3 3 3 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 AAS54041.2 - 5.1e-50 169.8 0.2 1.2e-45 155.5 0.0 3.2 2 0 0 2 2 2 2 Diaphanous FH3 Domain Drf_GBD PF06371.13 AAS54041.2 - 6.4e-31 107.4 1.8 1.2e-30 106.4 0.2 2.4 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain DUF148 PF02520.17 AAS54041.2 - 0.0078 16.3 3.8 0.0078 16.3 3.8 3.2 4 0 0 4 4 4 1 Domain of unknown function DUF148 DUF2935 PF11155.8 AAS54041.2 - 0.8 10.0 5.0 1.3 9.4 1.1 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) Sec2p PF06428.11 AAS54042.1 - 8.7e-28 96.1 13.6 8.7e-28 96.1 13.6 3.7 1 1 1 2 2 2 1 GDP/GTP exchange factor Sec2p Ly49 PF08391.10 AAS54042.1 - 0.4 11.0 5.6 1.1 9.6 1.0 2.9 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region HlyD_2 PF12700.7 AAS54042.1 - 1.3 7.7 10.3 0.079 11.7 3.6 2.1 1 1 1 2 2 2 0 HlyD family secretion protein UPF0160 PF03690.13 AAS54042.1 - 1.5 8.4 7.4 2.8 7.5 7.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) Aa_trans PF01490.18 AAS54043.2 - 3.7e-84 282.8 25.6 4.3e-84 282.6 25.6 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2427 PF10348.9 AAS54043.2 - 0.22 11.3 3.9 2 8.2 1.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF2427) TIMELESS PF04821.14 AAS54044.2 - 2.1e-86 289.7 0.1 4.2e-86 288.6 0.1 1.5 1 0 0 1 1 1 1 Timeless protein RRM_Rrp7 PF17799.1 AAS54044.2 - 8.4 6.2 8.5 8.8 6.1 0.1 3.3 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain Sad1_UNC PF07738.13 AAS54045.1 - 3.4e-30 104.7 0.1 6.6e-30 103.8 0.1 1.5 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Peptidase_M1 PF01433.20 AAS54046.1 - 1.6e-05 24.6 0.0 3.2e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AAS54046.1 - 0.0058 16.8 0.3 0.39 10.9 0.0 2.6 2 0 0 2 2 2 2 Peptidase M1 N-terminal domain 2-Hacid_dh_C PF02826.19 AAS54047.1 - 1.3e-56 190.8 0.0 2.5e-56 189.9 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AAS54047.1 - 1.9e-12 47.0 0.0 2.3e-12 46.7 0.0 1.1 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain IlvN PF07991.12 AAS54047.1 - 0.0028 17.2 0.0 0.0067 16.0 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 AAS54047.1 - 0.0048 17.1 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 AAS54047.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 AAS54047.1 - 0.055 13.5 0.0 0.29 11.2 0.0 2.0 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 AAS54047.1 - 0.11 13.0 0.0 0.26 11.8 0.0 1.6 1 0 0 1 1 1 0 XdhC Rossmann domain Sacchrp_dh_NADP PF03435.18 AAS54047.1 - 0.15 12.3 0.3 1.5 9.1 0.3 2.4 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain DUF1345 PF07077.11 AAS54048.2 - 0.056 13.2 2.6 0.088 12.5 1.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1345) HCO3_cotransp PF00955.21 AAS54049.2 - 6.4e-73 246.3 8.5 1e-39 136.8 1.1 2.1 1 1 1 2 2 2 2 HCO3- transporter family Per1 PF04080.13 AAS54050.2 - 4e-88 295.5 4.1 4.8e-88 295.2 4.1 1.1 1 0 0 1 1 1 1 Per1-like family DUF3522 PF12036.8 AAS54050.2 - 0.0032 17.8 4.9 0.0056 17.0 4.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Spindle_Spc25 PF08234.12 AAS54051.1 - 9.8e-18 64.1 0.0 1.6e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Chromosome segregation protein Spc25 KASH_CCD PF14662.6 AAS54051.1 - 5.2e-07 29.7 12.9 6.9e-07 29.3 12.9 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF3584 PF12128.8 AAS54051.1 - 0.00027 18.6 13.1 0.00034 18.3 13.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) APG6_N PF17675.1 AAS54051.1 - 0.003 18.1 17.7 0.003 18.1 17.7 1.7 1 1 0 1 1 1 1 Apg6 coiled-coil region ATG16 PF08614.11 AAS54051.1 - 0.012 15.8 25.3 0.017 15.4 16.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) RNase_E_G PF10150.9 AAS54051.1 - 0.014 14.8 3.3 0.018 14.4 3.3 1.1 1 0 0 1 1 1 0 Ribonuclease E/G family DUF2353 PF09789.9 AAS54051.1 - 0.027 13.9 13.7 0.035 13.5 13.7 1.1 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) MmoB_DmpM PF02406.17 AAS54051.1 - 0.05 13.8 0.7 0.3 11.3 0.0 2.5 3 0 0 3 3 3 0 MmoB/DmpM family SprA-related PF12118.8 AAS54051.1 - 0.093 11.9 10.7 0.12 11.4 10.7 1.2 1 0 0 1 1 1 0 SprA-related family FapA PF03961.13 AAS54051.1 - 0.1 11.2 4.7 0.14 10.7 4.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4201 PF13870.6 AAS54051.1 - 0.17 11.6 14.2 0.41 10.3 14.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) Wzy_C_2 PF11846.8 AAS54051.1 - 0.19 11.7 7.0 0.069 13.1 3.9 1.7 1 1 1 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Golgin_A5 PF09787.9 AAS54051.1 - 0.26 10.7 15.8 0.35 10.3 15.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Fez1 PF06818.15 AAS54051.1 - 0.29 11.6 16.4 0.4 11.1 16.4 1.1 1 0 0 1 1 1 0 Fez1 Spc7 PF08317.11 AAS54051.1 - 0.3 9.9 16.0 0.64 8.8 16.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 AAS54051.1 - 0.35 11.1 21.0 0.79 9.9 21.0 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4200 PF13863.6 AAS54051.1 - 0.36 11.3 15.0 0.66 10.4 15.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) SNAPc19 PF15497.6 AAS54051.1 - 0.36 11.3 6.0 0.64 10.5 6.0 1.5 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 V_ATPase_I PF01496.19 AAS54051.1 - 0.37 8.7 6.3 0.43 8.5 6.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4239 PF14023.6 AAS54051.1 - 0.47 10.1 6.2 0.7 9.6 6.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Borrelia_P83 PF05262.11 AAS54051.1 - 0.49 8.8 6.4 0.6 8.5 6.4 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein IFT57 PF10498.9 AAS54051.1 - 0.55 9.1 10.6 0.85 8.5 10.6 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Atg14 PF10186.9 AAS54051.1 - 0.62 9.1 17.2 1 8.4 17.2 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 AAS54051.1 - 0.67 9.5 16.1 0.94 9.0 16.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit THOC7 PF05615.13 AAS54051.1 - 0.71 10.2 20.7 0.55 10.5 4.9 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 ERM PF00769.19 AAS54051.1 - 0.78 9.5 21.6 1.1 9.0 21.6 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Cnn_1N PF07989.11 AAS54051.1 - 0.78 9.9 9.4 3.6 7.8 9.0 2.1 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 GAS PF13851.6 AAS54051.1 - 0.9 8.9 16.9 1.6 8.0 16.9 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 AAS54051.1 - 0.92 8.8 16.2 1.3 8.3 16.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 AAS54051.1 - 0.97 9.5 21.8 1.4 8.9 21.8 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein CCDC53 PF10152.9 AAS54051.1 - 1.1 9.6 5.9 1.6 9.2 5.9 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Fmp27_WPPW PF10359.9 AAS54051.1 - 1.3 7.8 7.0 1.6 7.5 7.0 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Fungal_TACC PF12709.7 AAS54051.1 - 1.4 9.5 6.2 1.3 9.5 0.8 2.4 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 AAS54051.1 - 1.4 9.6 13.7 0.55 10.9 4.4 2.3 1 1 1 2 2 2 0 Initiation control protein YabA IFT20 PF14931.6 AAS54051.1 - 1.5 9.0 11.9 37 4.5 10.9 2.3 1 1 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 DUF3450 PF11932.8 AAS54051.1 - 2.3 7.5 18.0 5.1 6.3 17.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) TSC22 PF01166.18 AAS54051.1 - 2.4 8.5 7.0 0.31 11.4 1.8 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family Filament PF00038.21 AAS54051.1 - 2.9 7.4 20.2 7.3 6.1 20.2 1.6 1 1 0 1 1 1 0 Intermediate filament protein Macoilin PF09726.9 AAS54051.1 - 3.2 6.2 14.1 3.7 6.0 14.1 1.0 1 0 0 1 1 1 0 Macoilin family LCD1 PF09798.9 AAS54051.1 - 3.7 6.0 7.4 4.9 5.6 7.4 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF1664 PF07889.12 AAS54051.1 - 3.8 7.6 5.8 3.2 7.8 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc24 PF08286.11 AAS54051.1 - 4.5 7.6 12.2 2.2 8.6 1.9 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Tho2 PF11262.8 AAS54051.1 - 4.5 6.4 6.4 5.6 6.1 6.4 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DASH_Spc19 PF08287.11 AAS54051.1 - 9.3 6.1 18.6 13 5.6 17.9 1.6 1 1 1 2 2 2 0 Spc19 Exo_endo_phos PF03372.23 AAS54052.1 - 7.1e-15 55.2 0.3 9.4e-15 54.8 0.3 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FA_desaturase PF00487.24 AAS54052.1 - 0.078 12.8 3.8 1.1 9.0 1.3 2.2 2 0 0 2 2 2 0 Fatty acid desaturase GRAM PF02893.20 AAS54053.2 - 1.3e-31 108.8 3.5 1.6e-22 79.5 0.1 3.6 3 0 0 3 3 3 2 GRAM domain Glyco_transf_28 PF03033.20 AAS54053.2 - 2.4e-29 102.1 0.2 1.5e-28 99.6 0.0 2.2 2 0 0 2 2 2 1 Glycosyltransferase family 28 N-terminal domain PH PF00169.29 AAS54053.2 - 6e-09 36.4 0.3 1.1e-07 32.3 0.1 2.6 2 0 0 2 2 2 1 PH domain UDPGT PF00201.18 AAS54053.2 - 5e-08 32.2 0.1 1.3e-07 30.8 0.1 1.7 1 1 0 1 1 1 1 UDP-glucoronosyl and UDP-glucosyl transferase PH_11 PF15413.6 AAS54053.2 - 0.0014 19.0 1.8 0.0082 16.6 1.8 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 AAS54053.2 - 0.12 12.5 0.2 0.36 11.0 0.2 1.7 1 0 0 1 1 1 0 PH domain Glyco_tran_28_C PF04101.16 AAS54053.2 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Glycosyltransferase family 28 C-terminal domain Abhydrolase_1 PF00561.20 AAS54054.1 - 2.4e-63 214.2 0.0 4e-63 213.4 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AAS54054.1 - 2.4e-05 25.1 0.2 4.5e-05 24.2 0.2 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AAS54054.1 - 0.045 13.0 0.0 0.1 11.9 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Esterase PF00756.20 AAS54054.1 - 0.069 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Putative esterase ABC_membrane PF00664.23 AAS54055.1 - 2.4e-61 207.8 0.5 3e-61 207.5 0.5 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AAS54055.1 - 1.4e-29 103.3 0.0 3.9e-29 101.9 0.0 1.8 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AAS54055.1 - 2.4e-07 30.4 0.0 2.1e-05 24.0 0.0 2.3 1 1 1 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 AAS54055.1 - 0.0012 19.3 0.4 0.0048 17.3 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AAS54055.1 - 0.0022 18.2 0.2 0.038 14.3 0.2 2.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS54055.1 - 0.0067 17.0 0.1 0.47 11.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AAS54055.1 - 0.023 14.7 0.0 0.13 12.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 AAS54055.1 - 0.048 14.1 0.8 1.3 9.5 0.9 2.8 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 AAS54055.1 - 0.055 13.2 0.1 1 9.1 0.1 2.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_29 PF13555.6 AAS54055.1 - 0.07 12.9 0.0 0.24 11.2 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 AAS54055.1 - 0.073 13.2 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain SbcCD_C PF13558.6 AAS54055.1 - 0.4 10.9 3.0 1.9 8.8 0.7 3.1 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit PH PF00169.29 AAS54056.2 - 2.5e-06 28.0 0.0 0.0015 19.0 0.0 2.8 2 0 0 2 2 2 2 PH domain EMG1 PF03587.14 AAS54058.1 - 4.8e-78 261.3 0.0 5.7e-78 261.0 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase RP854 PF17460.2 AAS54058.1 - 0.18 11.5 0.0 0.27 11.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein RP854 LCD1 PF09798.9 AAS54059.1 - 1.8e-182 608.1 11.4 2.1e-182 607.9 11.4 1.0 1 0 0 1 1 1 1 DNA damage checkpoint protein Ribosomal_L37e PF01907.19 AAS54060.1 - 1e-28 99.3 11.2 1.5e-28 98.7 11.2 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DZR PF12773.7 AAS54060.1 - 0.0046 17.0 1.3 0.0068 16.4 1.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon SelR PF01641.18 AAS54060.1 - 0.015 15.4 0.4 0.017 15.2 0.4 1.2 1 0 0 1 1 1 0 SelR domain DUF1258 PF06869.12 AAS54060.1 - 0.12 11.9 3.3 0.12 11.8 2.9 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1258) Zn-ribbon_8 PF09723.10 AAS54060.1 - 0.19 11.9 2.0 0.34 11.0 2.0 1.5 1 1 0 1 1 1 0 Zinc ribbon domain HypA PF01155.19 AAS54060.1 - 0.19 11.8 1.0 0.27 11.3 1.0 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AAS54060.1 - 0.24 10.9 3.2 0.58 9.7 3.2 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AAS54060.1 - 0.38 10.5 4.7 6.6 6.6 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain FHA PF00498.26 AAS54061.1 - 1.6e-06 28.4 0.1 1.1e-05 25.7 0.0 2.3 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 AAS54061.1 - 0.0031 17.8 0.0 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 Inner membrane component of T3SS, cytoplasmic domain Polysacc_deac_3 PF15421.6 AAS54061.1 - 0.026 13.0 0.0 0.038 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative polysaccharide deacetylase Swi6_N PF18530.1 AAS54062.2 - 4.2e-14 52.6 0.0 1.6e-13 50.7 0.0 2.0 1 0 0 1 1 1 1 Swi6 N-terminal domain Ank_3 PF13606.6 AAS54062.2 - 2.5e-09 36.6 0.6 0.00057 20.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 AAS54062.2 - 1.9e-08 34.8 0.0 0.0044 17.6 0.0 3.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AAS54062.2 - 3.6e-08 33.5 1.3 2.5e-05 24.5 0.1 3.3 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 AAS54062.2 - 6.2e-07 29.8 0.5 0.013 16.1 0.0 4.0 3 1 1 4 4 3 2 Ankyrin repeats (many copies) Ank PF00023.30 AAS54062.2 - 8.6e-07 29.1 2.4 0.0016 18.8 0.1 3.2 3 0 0 3 3 2 2 Ankyrin repeat Jnk-SapK_ap_N PF09744.9 AAS54062.2 - 0.035 14.3 11.8 0.37 11.0 4.5 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Phage_GPO PF05929.11 AAS54062.2 - 0.05 13.2 5.5 0.018 14.7 1.8 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase CENP-K PF11802.8 AAS54062.2 - 0.3 10.6 9.8 3.7 7.0 0.2 2.2 1 1 0 2 2 2 0 Centromere-associated protein K DUF1043 PF06295.12 AAS54062.2 - 0.33 10.9 2.7 18 5.3 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) PP1_inhibitor PF05361.12 AAS54062.2 - 0.39 10.7 5.4 1.6 8.8 1.0 2.6 2 0 0 2 2 2 0 PKC-activated protein phosphatase-1 inhibitor DUF2096 PF09869.9 AAS54062.2 - 0.39 10.8 2.5 0.46 10.6 0.3 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) SesA PF17107.5 AAS54062.2 - 0.76 10.0 6.3 0.24 11.6 0.2 2.5 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Fez1 PF06818.15 AAS54062.2 - 2 8.8 12.3 6.4 7.2 12.1 1.8 1 1 1 2 2 2 0 Fez1 OmpH PF03938.14 AAS54062.2 - 2.9 8.2 11.9 0.85 10.0 3.0 2.5 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) BLOC1_2 PF10046.9 AAS54062.2 - 3 8.2 9.4 9.8 6.6 0.2 2.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4140 PF13600.6 AAS54062.2 - 3.1 8.3 5.1 9.3 6.8 0.9 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) ADIP PF11559.8 AAS54062.2 - 3.2 7.8 13.2 0.21 11.7 0.6 3.0 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Baculo_PEP_C PF04513.12 AAS54062.2 - 3.5 7.7 7.1 1.5 8.9 1.3 2.7 3 1 0 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Macoilin PF09726.9 AAS54062.2 - 4.4 5.7 9.3 4.2 5.8 4.4 2.0 2 0 0 2 2 2 0 Macoilin family Seryl_tRNA_N PF02403.22 AAS54062.2 - 8.4 6.7 10.5 8.9 6.6 5.2 2.6 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Vta1 PF04652.16 AAS54063.1 - 7.9e-30 103.7 0.2 1.7e-29 102.7 0.0 1.5 2 0 0 2 2 2 1 Vta1 like Vta1_C PF18097.1 AAS54063.1 - 1e-13 50.7 3.7 1.6e-13 50.1 1.8 2.2 2 0 0 2 2 2 1 Vta1 C-terminal domain S-AdoMet_synt_C PF02773.16 AAS54064.1 - 1.5e-63 212.9 0.0 2.4e-63 212.2 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_N PF00438.20 AAS54064.1 - 4.5e-45 152.4 0.1 8.9e-45 151.4 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain S-AdoMet_synt_M PF02772.16 AAS54064.1 - 3.9e-44 149.7 0.0 1.4e-43 148.0 0.0 1.9 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain AdoMet_Synthase PF01941.19 AAS54064.1 - 0.046 12.5 0.1 0.13 11.0 0.0 1.7 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) PAP2 PF01569.21 AAS54065.1 - 2.7e-23 82.2 1.0 2.7e-23 82.2 1.0 1.8 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AAS54065.1 - 1.5e-06 28.0 2.0 1.5e-06 28.0 2.0 1.9 3 0 0 3 3 3 1 PAP2 superfamily PAP2_C PF14360.6 AAS54065.1 - 0.0041 17.6 0.3 0.037 14.6 0.1 2.2 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PBP PF01161.20 AAS54066.1 - 1e-15 58.2 0.0 1.3e-15 57.9 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein PSP1 PF04468.12 AAS54067.1 - 2e-43 146.5 0.0 4.4e-43 145.5 0.0 1.6 1 0 0 1 1 1 1 PSP1 C-terminal conserved region Pkinase PF00069.25 AAS54068.1 - 4.2e-73 245.9 1.8 2.9e-72 243.2 0.0 2.8 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54068.1 - 1e-35 123.3 0.0 2.5e-35 122.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase Fungal_KA1 PF16797.5 AAS54068.1 - 1.5e-35 121.4 1.6 3.7e-35 120.2 1.6 1.7 1 0 0 1 1 1 1 Fungal kinase associated-1 domain Kinase-like PF14531.6 AAS54068.1 - 6.3e-08 32.3 0.0 7.5e-06 25.5 0.0 2.5 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 AAS54068.1 - 5.2 6.9 6.5 0.97 9.3 0.1 2.4 2 0 0 2 2 2 0 Phosphotransferase enzyme family Glyco_trans_1_2 PF13524.6 AAS54068.1 - 8.6 6.8 8.3 22 5.5 8.3 1.7 1 0 0 1 1 1 0 Glycosyl transferases group 1 Rad60-SLD PF11976.8 AAS54069.1 - 3.4e-20 71.6 0.2 5e-20 71.1 0.1 1.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 AAS54069.1 - 3.6e-13 49.1 0.0 4.3e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin family AA_permease PF00324.21 AAS54070.1 - 3.1e-129 431.7 33.0 3.6e-129 431.5 33.0 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54070.1 - 1.9e-28 99.4 32.3 2.4e-28 99.1 32.3 1.1 1 0 0 1 1 1 1 Amino acid permease Vma12 PF11712.8 AAS54070.1 - 0.016 15.3 0.2 2.9 7.9 0.2 2.5 1 1 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Na_Ala_symp PF01235.17 AAS54070.1 - 0.063 12.6 16.9 0.17 11.1 16.7 2.0 1 1 0 1 1 1 0 Sodium:alanine symporter family SH3_9 PF14604.6 AAS54071.1 - 9.5e-08 31.8 0.0 1.5e-06 28.0 0.0 2.3 1 1 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AAS54071.1 - 0.015 14.9 0.0 0.035 13.7 0.0 1.6 1 0 0 1 1 1 0 SH3 domain CAP PF00188.26 AAS54072.1 - 4.5e-20 72.8 1.4 9.9e-20 71.6 1.4 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family CAP_GLY PF01302.25 AAS54074.2 - 2.9e-15 56.0 1.7 4.5e-15 55.4 0.3 2.0 2 0 0 2 2 2 1 CAP-Gly domain CLIP1_ZNF PF16641.5 AAS54074.2 - 0.00014 21.6 1.6 0.00024 20.9 1.6 1.4 1 0 0 1 1 1 1 CLIP1 zinc knuckle TP2 PF01254.18 AAS54074.2 - 0.39 11.3 5.1 3.4 8.3 4.2 2.3 2 0 0 2 2 2 0 Nuclear transition protein 2 zf-C2H2_aberr PF17017.5 AAS54074.2 - 0.53 10.4 3.8 0.35 11.0 2.0 1.5 2 0 0 2 2 2 0 Aberrant zinc-finger GAS PF13851.6 AAS54074.2 - 1.4 8.2 37.8 0.93 8.8 23.7 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ADIP PF11559.8 AAS54074.2 - 3.6 7.7 34.0 4.1 7.5 9.1 3.3 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Lectin_N PF03954.14 AAS54074.2 - 6.3 6.6 16.8 0.11 12.3 2.6 3.5 2 2 2 4 4 4 0 Hepatic lectin, N-terminal domain Fez1 PF06818.15 AAS54074.2 - 9.7 6.6 37.2 1.2 9.6 28.9 2.5 1 1 1 2 2 2 0 Fez1 Histidinol_dh PF00815.20 AAS54075.2 - 9.4e-158 525.5 2.5 1.3e-157 525.0 2.5 1.2 1 0 0 1 1 1 1 Histidinol dehydrogenase PRA-CH PF01502.18 AAS54075.2 - 1.1e-25 89.2 0.0 2.2e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase PRA-PH PF01503.17 AAS54075.2 - 1.6e-12 47.7 0.6 3.3e-12 46.7 0.6 1.6 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase MazG PF03819.17 AAS54075.2 - 0.0049 17.0 0.3 0.012 15.8 0.3 1.6 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain Complex1_LYR_2 PF13233.6 AAS54076.1 - 4.7e-20 72.1 0.0 2e-19 70.1 0.0 1.8 1 1 1 2 2 2 1 Complex1_LYR-like Complex1_LYR PF05347.15 AAS54076.1 - 1.2e-13 50.8 0.1 2.3e-12 46.8 0.0 2.3 3 0 0 3 3 3 1 Complex 1 protein (LYR family) Complex1_LYR_1 PF13232.6 AAS54076.1 - 0.0067 17.0 0.1 0.01 16.4 0.1 1.6 1 1 0 1 1 1 1 Complex1_LYR-like RRM_Rrp7 PF17799.1 AAS54077.2 - 1.7e-39 135.2 0.1 3.9e-39 134.1 0.0 1.6 2 0 0 2 2 2 1 Rrp7 RRM-like N-terminal domain RRP7 PF12923.7 AAS54077.2 - 2.7e-25 88.8 6.0 5.4e-25 87.8 6.0 1.5 1 0 0 1 1 1 1 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF5093 PF17011.5 AAS54077.2 - 0.0035 17.6 0.0 0.0035 17.6 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5093) Adenyl_cycl_N PF12633.7 AAS54077.2 - 0.011 15.7 0.1 0.027 14.4 0.1 1.6 1 0 0 1 1 1 0 Adenylate cyclase NT domain DUF223 PF02721.14 AAS54077.2 - 0.14 12.4 0.8 0.41 11.0 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function DUF223 Bclt PF15318.6 AAS54077.2 - 3.2 7.6 5.7 7.9 6.3 4.8 1.9 2 0 0 2 2 2 0 Putative Bcl-2 like protein of testis RA PF00788.23 AAS54078.1 - 2e-15 57.2 0.0 3.6e-15 56.4 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain SAM_Ste50p PF09235.10 AAS54078.1 - 2.9e-13 49.8 0.2 1.4e-09 38.0 0.0 2.4 2 0 0 2 2 2 2 Ste50p, sterile alpha motif SAM_2 PF07647.17 AAS54078.1 - 0.002 18.2 0.3 0.014 15.4 0.0 2.3 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4924 PF16271.5 AAS54078.1 - 0.022 14.8 0.0 0.039 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) SAM_1 PF00536.30 AAS54078.1 - 0.25 11.8 1.3 0.94 10.0 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF3128 PF11326.8 AAS54079.1 - 3.1e-23 81.9 1.0 3.6e-23 81.7 1.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3128) SelR PF01641.18 AAS54080.1 - 8.1e-47 158.3 0.0 9.3e-47 158.1 0.0 1.0 1 0 0 1 1 1 1 SelR domain zinc_ribbon_4 PF13717.6 AAS54080.1 - 0.047 13.6 0.2 0.27 11.2 0.0 2.3 2 0 0 2 2 2 0 zinc-ribbon domain LZ_Tnp_IS481 PF13011.6 AAS54080.1 - 0.05 14.1 0.2 0.13 12.8 0.1 1.7 2 0 0 2 2 2 0 leucine-zipper of insertion element IS481 Yippee-Mis18 PF03226.14 AAS54080.1 - 0.056 13.7 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-Mss51 PF13824.6 AAS54080.1 - 0.45 10.6 2.7 1.1 9.4 0.2 2.6 2 1 1 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 Tnp_zf-ribbon_2 PF13842.6 AAS54080.1 - 0.95 10.3 4.3 19 6.2 0.1 2.7 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon PG_binding_4 PF12229.8 AAS54081.1 - 0.003 17.8 0.1 0.0064 16.8 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain GAT PF03127.14 AAS54081.1 - 0.0052 17.1 0.0 0.015 15.6 0.0 1.9 1 0 0 1 1 1 1 GAT domain DUF3014 PF11219.8 AAS54081.1 - 0.037 14.3 0.0 0.077 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3014) VHS PF00790.19 AAS54081.1 - 0.045 13.6 0.1 0.08 12.8 0.1 1.5 1 0 0 1 1 1 0 VHS domain Glutaredoxin PF00462.24 AAS54082.1 - 2.9e-17 62.6 0.0 4.3e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 Glutaredoxin Thioredoxin_7 PF13899.6 AAS54082.1 - 0.0051 17.0 0.0 0.0076 16.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Tox-PL-2 PF15643.6 AAS54082.1 - 0.011 15.9 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Papain fold toxin 2 GST_N_3 PF13417.6 AAS54082.1 - 0.017 15.6 0.0 0.023 15.1 0.0 1.2 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain Thioredoxin_4 PF13462.6 AAS54082.1 - 0.04 14.1 0.1 0.82 9.8 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin Thioredoxin_3 PF13192.6 AAS54082.1 - 0.043 13.9 0.2 0.57 10.3 0.2 2.2 1 1 0 1 1 1 0 Thioredoxin domain DSBA PF01323.20 AAS54082.1 - 0.13 12.1 0.0 4.2 7.1 0.0 2.1 1 1 1 2 2 2 0 DSBA-like thioredoxin domain Flocculin_t3 PF13928.6 AAS54083.1 - 2.6e-05 24.6 6.8 2.6e-05 24.6 6.8 8.3 5 2 1 6 6 6 3 Flocculin type 3 repeat Lipase_chap PF03280.14 AAS54084.1 - 4.8 7.1 11.4 69 3.3 11.5 2.2 1 1 0 1 1 1 0 Proteobacterial lipase chaperone protein La PF05383.17 AAS54085.1 - 3.3e-17 62.3 0.1 7.4e-17 61.2 0.0 1.6 2 0 0 2 2 2 1 La domain ATG22 PF11700.8 AAS54086.1 - 3.6e-154 513.9 21.4 4.8e-154 513.5 21.4 1.1 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like MFS_1 PF07690.16 AAS54086.1 - 1.1e-06 27.8 32.8 4.1e-05 22.7 13.6 3.2 1 1 1 3 3 3 3 Major Facilitator Superfamily MFS_2 PF13347.6 AAS54086.1 - 0.0004 19.1 2.0 0.0004 19.1 2.0 2.3 2 0 0 2 2 2 2 MFS/sugar transport protein WD40 PF00400.32 AAS54087.1 - 9.8e-17 61.0 7.6 0.0043 17.8 0.0 6.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54087.1 - 4.7e-07 30.0 0.0 0.025 14.9 0.0 5.0 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS54087.1 - 0.002 18.0 0.2 1 9.2 0.0 3.3 3 1 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF2647 PF10839.8 AAS54087.1 - 0.0084 16.1 0.0 0.49 10.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2647) Kelch_2 PF07646.15 AAS54087.1 - 0.13 12.3 0.3 0.59 10.2 0.3 2.1 1 0 0 1 1 1 0 Kelch motif Hexokinase_2 PF03727.16 AAS54088.2 - 2.7e-75 252.9 0.0 3.6e-75 252.5 0.0 1.2 1 0 0 1 1 1 1 Hexokinase Hexokinase_1 PF00349.21 AAS54088.2 - 3.2e-72 242.6 0.0 5.2e-72 241.9 0.0 1.3 1 0 0 1 1 1 1 Hexokinase T3SS_needle_E PF08988.10 AAS54088.2 - 0.014 15.6 0.3 0.036 14.2 0.3 1.7 1 0 0 1 1 1 0 Type III secretion system, cytoplasmic E component of needle GRASP55_65 PF04495.14 AAS54089.1 - 2e-35 122.1 0.0 9.9e-34 116.6 0.0 2.1 1 1 0 2 2 2 2 GRASP55/65 PDZ-like domain Thioredoxin PF00085.20 AAS54090.2 - 7.5e-54 180.1 0.0 1.1e-26 92.8 0.0 3.5 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_6 PF13848.6 AAS54090.2 - 2.2e-23 83.1 0.3 3.4e-20 72.7 0.2 3.9 3 1 1 4 4 4 1 Thioredoxin-like domain AhpC-TSA PF00578.21 AAS54090.2 - 1.1e-07 31.8 0.1 0.0092 15.9 0.0 3.5 2 1 1 3 3 3 2 AhpC/TSA family Thioredoxin_2 PF13098.6 AAS54090.2 - 3.7e-07 30.5 1.1 0.019 15.4 0.2 3.4 2 2 0 2 2 2 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 AAS54090.2 - 1.6e-06 28.2 0.1 0.0059 16.8 0.0 3.3 3 0 0 3 3 3 2 Thioredoxin-like OST3_OST6 PF04756.13 AAS54090.2 - 3.6e-06 26.5 0.0 0.00071 19.0 0.0 2.8 2 1 1 3 3 3 1 OST3 / OST6 family, transporter family Thioredoxin_8 PF13905.6 AAS54090.2 - 0.00045 20.5 0.0 0.17 12.2 0.0 2.9 2 0 0 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 AAS54090.2 - 0.00046 19.9 0.4 0.13 11.9 0.1 2.9 2 1 1 3 3 3 1 Redoxin LSDAT_prok PF18171.1 AAS54090.2 - 0.019 14.2 0.0 1.2 8.3 0.0 2.3 2 0 0 2 2 2 0 SLOG in TRPM, prokaryote Thioredoxin_9 PF14595.6 AAS54090.2 - 0.027 14.3 0.0 6.9 6.5 0.0 2.4 2 0 0 2 2 2 0 Thioredoxin Thioredoxin_4 PF13462.6 AAS54090.2 - 0.028 14.6 0.3 4.1 7.5 0.1 2.7 2 0 0 2 2 2 0 Thioredoxin DUF1539 PF07560.11 AAS54090.2 - 0.037 14.1 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1539) Mgr1 PF08602.10 AAS54091.1 - 1.6e-146 488.1 0.0 1.8e-146 488.0 0.0 1.0 1 0 0 1 1 1 1 Mgr1-like, i-AAA protease complex subunit EMC1_C PF07774.13 AAS54092.1 - 7.5e-63 212.0 0.7 1.5e-62 211.0 0.5 1.6 2 0 0 2 2 2 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 AAS54092.1 - 0.00044 20.1 0.0 0.0014 18.4 0.0 1.9 1 0 0 1 1 1 1 PQQ enzyme repeat PQQ_2 PF13360.6 AAS54092.1 - 0.13 11.8 0.0 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 PQQ-like domain CTP_transf_like PF01467.26 AAS54093.1 - 3e-08 34.0 0.0 4.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like ATP-sulfurylase PF01747.17 AAS54093.1 - 0.055 12.9 0.0 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 ATP-sulfurylase Zn_clus PF00172.18 AAS54094.2 - 4.6e-06 26.6 7.2 8.8e-06 25.8 7.2 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Recep_L_domain PF01030.24 AAS54095.1 - 1.6e-08 34.7 7.7 0.0087 16.2 0.2 4.2 2 1 3 5 5 5 4 Receptor L domain LRR_4 PF12799.7 AAS54095.1 - 0.002 18.5 9.5 1.2 9.6 0.0 5.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) Leptin PF02024.15 AAS54095.1 - 0.027 14.3 0.3 0.53 10.0 0.0 2.8 4 0 0 4 4 4 0 Leptin Pkinase PF00069.25 AAS54096.1 - 1.3e-69 234.5 0.0 1.7e-69 234.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54096.1 - 2.1e-46 158.3 0.0 3e-46 157.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS54096.1 - 9.9e-05 21.8 0.0 0.0057 16.0 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 AAS54096.1 - 0.0066 15.3 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase ArfGap PF01412.18 AAS54097.1 - 1.6e-30 105.5 1.4 4.2e-30 104.2 1.4 1.8 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 AAS54097.1 - 9.2e-15 55.0 1.0 6.5e-14 52.3 0.2 2.9 3 0 0 3 3 3 1 PH domain BAR_3 PF16746.5 AAS54097.1 - 3.1e-07 30.4 5.6 6.1e-07 29.4 5.6 1.4 1 0 0 1 1 1 1 BAR domain of APPL family PH_9 PF15410.6 AAS54097.1 - 0.0044 17.4 0.2 0.019 15.3 0.2 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 AAS54097.1 - 0.035 14.5 6.2 0.053 13.9 2.9 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain SPOC PF07744.13 AAS54097.1 - 0.073 13.0 1.1 0.4 10.6 0.0 2.2 2 0 0 2 2 2 0 SPOC domain Pmp3 PF01679.17 AAS54098.1 - 9.4e-13 48.1 2.8 1.3e-12 47.7 2.8 1.2 1 0 0 1 1 1 1 Proteolipid membrane potential modulator RPAP1_C PF08620.10 AAS54099.2 - 1.5e-29 101.9 0.1 2.7e-29 101.1 0.1 1.4 1 0 0 1 1 1 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 AAS54099.2 - 3.7e-15 55.4 0.8 9.3e-15 54.1 0.8 1.7 1 0 0 1 1 1 1 RPAP1-like, N-terminal HEAT PF02985.22 AAS54099.2 - 0.039 14.2 0.0 0.16 12.3 0.0 2.1 1 0 0 1 1 1 0 HEAT repeat UNC45-central PF11701.8 AAS54099.2 - 0.058 13.4 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central Kre28 PF17097.5 AAS54100.2 - 4.7e-134 447.0 16.4 5.5e-134 446.8 16.4 1.0 1 0 0 1 1 1 1 Spindle pole body component DUF4407 PF14362.6 AAS54100.2 - 0.0072 15.7 1.2 0.014 14.8 1.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Dynactin_p22 PF07426.11 AAS54100.2 - 1.8 8.4 10.7 0.09 12.6 2.3 2.9 3 1 0 4 4 4 0 Dynactin subunit p22 Fumble PF03630.14 AAS54101.2 - 1.1e-126 422.5 1.7 7.8e-126 419.7 1.7 1.9 1 1 0 1 1 1 1 Fumble ATP_transf PF09830.9 AAS54102.2 - 8.7e-16 57.8 0.0 2.5e-15 56.4 0.0 1.8 2 0 0 2 2 2 1 ATP adenylyltransferase HIT PF01230.23 AAS54102.2 - 6.3e-07 30.1 0.0 1.5e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 HIT domain DUF4931 PF16285.5 AAS54102.2 - 0.011 15.0 0.0 0.024 14.0 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4931) UCR_14kD PF02271.16 AAS54103.1 - 1e-39 134.5 0.2 1.2e-39 134.3 0.2 1.0 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase complex 14kD subunit Senescence_reg PF04520.13 AAS54104.1 - 1.5 9.6 6.0 10 6.9 1.5 2.1 1 1 1 2 2 2 0 Senescence regulator PIG-X PF08320.12 AAS54105.2 - 7e-29 101.2 0.0 1.3e-28 100.4 0.0 1.4 1 0 0 1 1 1 1 PIG-X / PBN1 Spb1_C PF07780.12 AAS54106.2 - 2.9e-86 288.5 27.5 2.9e-86 288.5 27.5 3.1 3 0 0 3 3 3 1 Spb1 C-terminal domain FtsJ PF01728.19 AAS54106.2 - 6.1e-55 186.1 0.1 1.2e-54 185.1 0.1 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF3381 PF11861.8 AAS54106.2 - 1e-48 165.3 17.1 1e-48 165.3 17.1 5.4 5 1 1 6 6 6 1 Domain of unknown function (DUF3381) Methyltransf_23 PF13489.6 AAS54106.2 - 0.1 12.4 0.0 0.25 11.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain CMAS PF02353.20 AAS54107.1 - 3.8e-61 206.8 0.1 4.7e-61 206.5 0.1 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_25 PF13649.6 AAS54107.1 - 1.4e-09 38.5 0.0 3.3e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS54107.1 - 2.9e-09 37.5 0.0 8.2e-09 36.0 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS54107.1 - 5.1e-09 36.2 0.0 7.9e-09 35.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS54107.1 - 0.00015 22.4 0.0 0.00031 21.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 AAS54107.1 - 0.00067 19.8 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AAS54107.1 - 0.0023 17.7 0.1 0.0083 15.9 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AAS54107.1 - 0.0062 16.1 0.0 0.011 15.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 AAS54107.1 - 0.017 14.9 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 AAS54107.1 - 0.078 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F DOT1 PF08123.13 AAS54107.1 - 0.087 12.3 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 COX7C PF02935.16 AAS54107.1 - 6.3 7.1 5.9 23 5.4 4.3 2.4 1 1 1 2 2 2 0 Cytochrome c oxidase subunit VIIc MT-A70 PF05063.14 AAS54108.1 - 3e-12 46.8 0.0 4.5e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 MT-A70 Voltage_CLC PF00654.20 AAS54110.2 - 1.5e-79 267.8 16.5 1.5e-79 267.8 16.5 1.6 2 0 0 2 2 2 1 Voltage gated chloride channel SEO_C PF14577.6 AAS54111.1 - 0.025 14.0 0.3 0.039 13.4 0.3 1.2 1 0 0 1 1 1 0 Sieve element occlusion C-terminus THDPS_N_2 PF14805.6 AAS54111.1 - 0.22 11.8 0.0 7.6 6.8 0.0 2.3 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal 2OG-FeII_Oxy_2 PF13532.6 AAS54113.1 - 1.2e-21 77.8 0.0 1.6e-21 77.4 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Zn_ribbon_recom PF13408.6 AAS54113.1 - 0.008 16.7 3.7 0.021 15.3 3.7 1.7 1 0 0 1 1 1 1 Recombinase zinc beta ribbon domain Peptidase_M2 PF01401.18 AAS54113.1 - 0.11 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Angiotensin-converting enzyme ScdA_N PF04405.14 AAS54113.1 - 0.17 11.5 1.0 1.5 8.6 0.4 2.5 2 0 0 2 2 2 0 Domain of Unknown function (DUF542) NCKAP5 PF15246.6 AAS54113.1 - 0.26 10.9 0.0 0.38 10.3 0.0 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein DUF543 PF04418.12 AAS54115.1 - 3.4e-32 110.3 0.6 3.9e-32 110.1 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF543) PGC7_Stella PF15549.6 AAS54116.1 - 0.072 13.1 1.4 0.084 12.9 1.4 1.2 1 0 0 1 1 1 0 PGC7/Stella/Dppa3 domain KH_8 PF17903.1 AAS54117.2 - 2.6e-32 110.7 0.1 5.2e-32 109.8 0.1 1.5 1 0 0 1 1 1 1 Krr1 KH1 domain KH_1 PF00013.29 AAS54117.2 - 0.047 13.5 0.0 0.095 12.5 0.0 1.5 1 0 0 1 1 1 0 KH domain DUF913 PF06025.12 AAS54117.2 - 8 5.3 6.5 29 3.5 6.2 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) MRC1 PF09444.10 AAS54118.1 - 1.3e-37 129.6 6.9 1.3e-37 129.6 6.9 4.7 3 2 2 5 5 5 1 MRC1-like domain DUF722 PF05263.11 AAS54118.1 - 0.45 10.7 10.3 0.11 12.8 3.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF722) Vac17 PF17321.2 AAS54119.1 - 1.4e-06 28.1 4.5 0.0012 18.3 2.3 2.4 2 1 0 2 2 2 2 Vacuole-related protein 17 PALP PF00291.25 AAS54120.1 - 1e-55 189.2 0.0 1.2e-55 189.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme BPD_transp_1 PF00528.22 AAS54121.1 - 0.047 13.4 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Binding-protein-dependent transport system inner membrane component Pox_A14 PF05767.12 AAS54122.1 - 0.59 10.3 5.4 0.72 10.0 2.6 2.3 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Fun_ATP-synt_8 PF05933.13 AAS54124.1 - 5.3e-13 48.9 10.1 5.6e-13 48.8 10.1 1.0 1 0 0 1 1 1 1 Fungal ATP synthase protein 8 (A6L) PTR2 PF00854.21 AAS54126.1 - 8.2e-54 182.9 5.6 1.2e-53 182.4 5.6 1.1 1 0 0 1 1 1 1 POT family MFS_1 PF07690.16 AAS54126.1 - 1.3e-08 34.2 20.5 6.7e-07 28.6 0.3 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily 7TM_GPCR_Srh PF10318.9 AAS54126.1 - 0.004 16.2 3.4 0.004 16.2 3.4 2.4 3 1 0 3 3 3 1 Serpentine type 7TM GPCR chemoreceptor Srh FH2 PF02181.23 AAS54127.1 - 1.9e-73 247.7 9.0 1.9e-73 247.7 9.0 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain Drf_GBD PF06371.13 AAS54127.1 - 0.00025 20.7 1.1 0.00025 20.7 1.1 3.1 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain ssDNA_DBD PF18333.1 AAS54127.1 - 0.095 12.8 2.2 0.72 10.0 0.1 3.3 2 0 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain AAA_19 PF13245.6 AAS54127.1 - 0.26 11.6 1.9 0.33 11.3 0.2 2.0 2 0 0 2 2 2 0 AAA domain Drf_FH3 PF06367.16 AAS54127.1 - 0.26 10.9 9.9 0.41 10.2 4.2 3.2 2 1 0 2 2 2 0 Diaphanous FH3 Domain Ku_PK_bind PF08785.11 AAS54127.1 - 2.4 8.3 7.7 1.3 9.2 1.6 2.9 2 1 0 2 2 2 0 Ku C terminal domain like Transp_cyt_pur PF02133.15 AAS54128.1 - 3.7e-69 233.6 32.1 4.8e-69 233.2 32.1 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin DUF3545 PF12065.8 AAS54129.1 - 0.11 12.5 1.5 0.19 11.8 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3545) Zn_clus PF00172.18 AAS54130.1 - 9.5e-08 32.0 8.6 1.9e-07 31.1 8.6 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Fungal_trans_2 PF11951.8 AAS54130.1 - 1.5e-06 27.3 0.3 2.8e-06 26.4 0.3 1.3 1 0 0 1 1 1 1 Fungal specific transcription factor domain ADH_N_2 PF16884.5 AAS54131.1 - 3.7e-15 55.7 0.0 6.1e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase ADH_zinc_N PF00107.26 AAS54131.1 - 2.6e-14 53.3 0.4 4.1e-14 52.7 0.4 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AAS54131.1 - 0.0024 18.9 0.0 0.0041 18.2 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase NAD_binding_10 PF13460.6 AAS54131.1 - 0.11 12.4 0.2 0.23 11.3 0.2 1.7 1 1 0 1 1 1 0 NAD(P)H-binding DUF5341 PF17276.2 AAS54132.2 - 1.1e-46 158.9 0.0 1.6e-46 158.4 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5341) RNA12 PF10443.9 AAS54133.1 - 3.5e-175 583.0 0.0 9.7e-175 581.6 0.0 1.8 1 1 0 1 1 1 1 RNA12 protein ATPase_2 PF01637.18 AAS54133.1 - 2.4e-07 30.9 0.4 3.7e-06 27.0 0.1 2.6 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea RRM_1 PF00076.22 AAS54133.1 - 3.4e-07 30.0 0.0 1e-06 28.5 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AAA_14 PF13173.6 AAS54133.1 - 0.0043 17.1 0.0 0.033 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain PBECR5 PF18814.1 AAS54133.1 - 0.06 13.3 0.1 1.3 8.9 0.1 2.3 1 1 1 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 USP7_C2 PF14533.6 AAS54134.1 - 1.4e-62 211.0 4.5 9e-60 201.9 2.1 3.5 3 0 0 3 3 3 1 Ubiquitin-specific protease C-terminal UCH PF00443.29 AAS54134.1 - 4.8e-46 157.3 1.2 1e-45 156.2 1.2 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 AAS54134.1 - 1.1e-33 116.5 6.9 1.8e-33 115.9 0.2 3.0 3 1 0 3 3 3 1 ICP0-binding domain of Ubiquitin-specific protease 7 UCH_1 PF13423.6 AAS54134.1 - 2.4e-22 80.0 0.0 2.2e-21 76.8 0.0 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MATH PF00917.26 AAS54134.1 - 0.0073 16.5 0.0 0.031 14.4 0.0 2.2 1 0 0 1 1 1 1 MATH domain UN_NPL4 PF11543.8 AAS54134.1 - 0.29 11.7 3.5 0.79 10.3 0.0 3.5 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 CTP_transf_like PF01467.26 AAS54135.1 - 4.1e-14 53.0 0.0 5.9e-14 52.5 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like MA3 PF02847.17 AAS54136.1 - 8.5e-22 77.3 0.0 2.2e-21 76.0 0.0 1.8 1 0 0 1 1 1 1 MA3 domain Tautomerase_2 PF14552.6 AAS54136.1 - 0.1 12.7 0.0 21 5.3 0.0 2.5 2 0 0 2 2 2 0 Tautomerase enzyme Glyco_hydro_17 PF00332.18 AAS54137.1 - 1.9e-09 37.6 0.7 9.7e-09 35.2 0.1 2.2 1 1 1 2 2 2 1 Glycosyl hydrolases family 17 SOG2 PF10428.9 AAS54137.1 - 7.8 5.6 20.9 11 5.1 20.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Glucan_synthase PF02364.15 AAS54138.1 - 0 1360.2 0.0 0 1360.2 0.0 1.7 3 0 0 3 3 3 1 1,3-beta-glucan synthase component FKS1_dom1 PF14288.6 AAS54138.1 - 4.3e-41 140.3 0.6 1.9e-40 138.2 0.6 2.2 1 1 0 1 1 1 1 1,3-beta-glucan synthase subunit FKS1, domain-1 Glyco_hydro_72 PF03198.14 AAS54139.2 - 7.6e-137 455.8 7.1 1e-136 455.4 7.1 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AAS54139.2 - 1.5e-24 86.4 6.4 4.4e-24 85.0 6.4 1.9 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 AAS54139.2 - 0.00062 19.3 0.2 0.0044 16.5 0.2 2.0 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) DCX PF03607.17 AAS54139.2 - 0.16 12.1 0.1 1 9.5 0.0 2.3 3 0 0 3 3 3 0 Doublecortin Glyco_hydro_72 PF03198.14 AAS54140.2 - 1.7e-140 467.8 6.9 2.2e-140 467.4 6.9 1.1 1 0 0 1 1 1 1 Glucanosyltransferase X8 PF07983.13 AAS54140.2 - 6.8e-27 94.0 3.6 1.9e-26 92.5 3.6 1.9 1 0 0 1 1 1 1 X8 domain Cellulase PF00150.18 AAS54140.2 - 0.0036 16.8 0.2 0.077 12.4 0.2 2.1 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Ribosomal_L7Ae PF01248.26 AAS54140.2 - 0.016 14.9 0.1 0.034 13.9 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family G-patch PF01585.23 AAS54141.1 - 1.6e-10 40.7 0.1 3.4e-10 39.7 0.1 1.6 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 AAS54141.1 - 0.0067 16.5 0.2 0.0067 16.5 0.2 3.7 2 1 0 2 2 2 1 G-patch domain Macoilin PF09726.9 AAS54141.1 - 0.37 9.3 23.2 0.44 9.0 23.2 1.1 1 0 0 1 1 1 0 Macoilin family Mem_trans PF03547.18 AAS54141.1 - 1 7.6 6.4 1.5 7.1 6.4 1.2 1 0 0 1 1 1 0 Membrane transport protein CDC27 PF09507.10 AAS54141.1 - 1.4 8.2 46.7 2.3 7.5 46.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GREB1 PF15782.5 AAS54141.1 - 3.3 4.7 22.5 4.1 4.4 22.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Importin_rep_6 PF18829.1 AAS54142.2 - 8.2e-49 164.2 1.8 8.2e-49 164.2 1.8 4.4 4 1 1 5 5 5 1 Importin repeat 6 Importin_rep_4 PF18808.1 AAS54142.2 - 6.6e-32 109.7 1.3 6.6e-32 109.7 1.3 3.9 4 1 1 5 5 4 1 Importin repeat Importin_rep_5 PF18816.1 AAS54142.2 - 1.5e-23 82.9 0.1 1.5e-23 82.9 0.1 2.6 3 0 0 3 3 3 1 Importin repeat HEAT_EZ PF13513.6 AAS54142.2 - 3.5e-21 75.3 0.5 5.7e-11 42.7 0.0 6.7 5 1 1 6 6 6 3 HEAT-like repeat HEAT_2 PF13646.6 AAS54142.2 - 8.8e-13 48.5 0.1 5.1e-06 26.8 0.0 6.4 4 2 3 7 7 7 3 HEAT repeats HEAT PF02985.22 AAS54142.2 - 1.9e-12 46.3 2.7 0.056 13.7 0.0 8.4 10 0 0 10 10 8 2 HEAT repeat Adaptin_N PF01602.20 AAS54142.2 - 8e-08 31.3 0.4 1.8 7.0 0.0 4.6 3 2 0 4 4 4 4 Adaptin N terminal region RIX1 PF08167.12 AAS54142.2 - 7.4e-06 25.8 0.8 0.00035 20.4 0.5 3.2 2 1 1 3 3 3 1 rRNA processing/ribosome biogenesis Vac14_Fab1_bd PF12755.7 AAS54142.2 - 9.1e-06 26.2 0.0 0.16 12.5 0.0 5.7 3 1 3 6 6 5 1 Vacuolar 14 Fab1-binding region MMS19_C PF12460.8 AAS54142.2 - 1.5e-05 24.4 10.1 0.0053 15.9 4.6 3.5 3 0 0 3 3 3 2 RNAPII transcription regulator C-terminal DUF3385 PF11865.8 AAS54142.2 - 2.9e-05 24.0 2.7 0.011 15.6 0.4 4.6 4 2 2 6 6 6 1 Domain of unknown function (DUF3385) Arm PF00514.23 AAS54142.2 - 3.6e-05 23.7 0.1 5.1 7.3 0.1 4.4 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat CLASP_N PF12348.8 AAS54142.2 - 0.00062 19.4 3.1 0.22 11.1 0.7 4.3 5 1 1 6 6 6 1 CLASP N terminal IFRD PF05004.13 AAS54142.2 - 0.001 18.3 5.7 0.014 14.5 0.5 3.7 3 0 0 3 3 3 1 Interferon-related developmental regulator (IFRD) ParcG PF10274.9 AAS54142.2 - 0.0039 17.3 0.7 0.4 10.8 0.0 3.1 2 1 0 2 2 2 1 Parkin co-regulated protein DNA_alkylation PF08713.11 AAS54142.2 - 0.078 12.7 0.0 0.25 11.0 0.0 1.9 1 0 0 1 1 1 0 DNA alkylation repair enzyme Fungal_trans PF04082.18 AAS54143.1 - 3.1e-15 55.9 0.7 7.5e-15 54.7 0.0 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain CBS PF00571.28 AAS54144.1 - 1.8e-20 73.1 0.7 3.3e-05 24.2 0.0 5.2 5 0 0 5 5 5 4 CBS domain DUF1491 PF07372.12 AAS54144.1 - 0.027 14.8 0.2 0.054 13.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) ABC_membrane PF00664.23 AAS54145.2 - 2.5e-60 204.4 35.5 2.8e-39 135.5 15.6 2.1 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AAS54145.2 - 3.5e-45 153.9 0.1 5.9e-27 94.9 0.0 3.6 3 1 0 3 3 2 2 ABC transporter SMC_N PF02463.19 AAS54145.2 - 4.1e-11 42.7 0.0 0.0004 19.9 0.0 3.8 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 AAS54145.2 - 7.2e-05 23.2 0.8 0.012 16.0 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 AAS54145.2 - 0.00013 21.9 1.5 0.0088 16.0 0.2 2.5 2 0 0 2 2 2 1 RsgA GTPase ATP-synt_ab PF00006.25 AAS54145.2 - 0.00025 20.8 0.1 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain AAA PF00004.29 AAS54145.2 - 0.0011 19.3 0.2 0.1 13.0 0.0 3.2 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 AAS54145.2 - 0.0014 18.0 0.3 0.16 11.2 0.0 2.5 2 0 0 2 2 2 1 Zeta toxin IstB_IS21 PF01695.17 AAS54145.2 - 0.0046 16.7 0.6 1.9 8.2 0.0 3.0 3 0 0 3 3 3 1 IstB-like ATP binding protein AAA_18 PF13238.6 AAS54145.2 - 0.0047 17.5 2.9 2 9.0 0.2 2.9 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 AAS54145.2 - 0.0056 16.5 5.5 6.3 6.5 0.0 4.1 3 1 0 4 4 4 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AAS54145.2 - 0.0085 15.8 1.9 0.21 11.3 0.4 2.6 2 0 0 2 2 2 1 P-loop containing region of AAA domain PduV-EutP PF10662.9 AAS54145.2 - 0.019 14.7 0.3 1.8 8.3 0.0 2.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 AAS54145.2 - 0.022 14.9 2.4 4.3 7.4 0.4 2.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.20 AAS54145.2 - 0.035 13.2 1.7 0.21 10.6 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_19 PF13245.6 AAS54145.2 - 0.085 13.2 0.5 1.7 9.0 0.2 2.8 2 0 0 2 2 2 0 AAA domain DUF2407_C PF13373.6 AAS54145.2 - 0.14 12.4 0.0 2.6 8.2 0.0 2.6 2 0 0 2 2 2 0 DUF2407 C-terminal domain TsaE PF02367.17 AAS54145.2 - 0.15 12.1 1.5 6.5 6.8 0.2 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 AAS54145.2 - 0.15 11.8 5.4 0.87 9.3 0.4 3.6 4 0 0 4 4 4 0 AAA domain AAA_25 PF13481.6 AAS54145.2 - 0.18 11.3 3.0 2 8.0 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 AAS54145.2 - 0.22 11.8 9.4 1.7 8.9 0.2 3.7 3 1 0 3 3 3 0 AAA domain Roc PF08477.13 AAS54145.2 - 0.32 11.2 2.6 21 5.4 0.2 2.9 3 0 0 3 3 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 AAS54145.2 - 0.44 10.0 5.0 7.3 6.1 0.2 3.1 4 0 0 4 4 3 0 P-loop containing dynein motor region Dynamin_N PF00350.23 AAS54145.2 - 1 9.4 6.1 0.78 9.8 0.5 2.8 3 0 0 3 3 2 0 Dynamin family AAA_28 PF13521.6 AAS54145.2 - 1.5 9.1 6.5 0.46 10.7 0.1 3.0 3 0 0 3 3 3 0 AAA domain DUF2207 PF09972.9 AAS54145.2 - 7.6 5.2 14.5 0.45 9.2 0.4 3.6 4 0 0 4 4 4 0 Predicted membrane protein (DUF2207) HMG_box PF00505.19 AAS54146.2 - 0.0077 16.6 0.0 1.4 9.4 0.0 2.5 2 0 0 2 2 2 2 HMG (high mobility group) box GSH-S_N PF02951.14 AAS54146.2 - 0.043 13.9 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Prokaryotic glutathione synthetase, N-terminal domain eIF-3c_N PF05470.12 AAS54147.1 - 1.3e-156 522.4 18.2 9.9e-122 407.2 3.1 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 AAS54147.1 - 4.9e-11 43.1 6.4 1.2e-10 41.8 0.7 4.0 4 1 0 4 4 4 1 PCI domain SQS_PSY PF00494.19 AAS54147.1 - 0.043 13.3 0.1 0.13 11.7 0.0 1.9 2 0 0 2 2 2 0 Squalene/phytoene synthase LIN52 PF10044.9 AAS54147.1 - 0.064 14.0 0.2 0.42 11.3 0.2 2.5 1 0 0 1 1 1 0 Retinal tissue protein Glyco_hydro_17 PF00332.18 AAS54148.2 - 6.1e-79 265.9 0.1 6.9e-79 265.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 17 Methyltrn_RNA_3 PF02598.17 AAS54149.1 - 1.6e-72 244.4 0.0 1.9e-72 244.2 0.0 1.1 1 0 0 1 1 1 1 Putative RNA methyltransferase AA_permease_N PF08403.10 AAS54149.1 - 0.014 14.8 0.1 0.032 13.7 0.1 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal IPP-2 PF04979.14 AAS54150.1 - 6e-19 69.1 6.8 6e-19 69.1 6.8 1.9 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) SURF4 PF02077.15 AAS54151.1 - 1.3e-94 316.7 11.9 1.5e-94 316.5 11.9 1.0 1 0 0 1 1 1 1 SURF4 family SAUGI PF06106.11 AAS54151.1 - 0.0072 16.8 0.4 0.025 15.1 0.0 2.0 2 1 1 3 3 3 1 S. aureus uracil DNA glycosylase inhibitor RAC_head PF16717.5 AAS54152.1 - 3.6e-20 72.8 3.6 3.6e-20 72.8 3.6 3.3 3 2 0 3 3 3 1 Ribosome-associated complex head domain DnaJ PF00226.31 AAS54152.1 - 9.9e-16 57.6 0.5 3.2e-15 56.0 0.5 2.0 1 0 0 1 1 1 1 DnaJ domain ELP6 PF09807.9 AAS54153.1 - 0.013 15.0 0.0 0.063 12.7 0.0 2.0 2 0 0 2 2 2 0 Elongation complex protein 6 DUF3336 PF11815.8 AAS54154.1 - 5.7e-25 87.6 0.0 1.1e-24 86.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Patatin PF01734.22 AAS54154.1 - 4.9e-08 33.4 0.0 1.1e-07 32.3 0.0 1.6 2 0 0 2 2 2 1 Patatin-like phospholipase Proteasome PF00227.26 AAS54155.1 - 2.5e-46 157.6 0.1 3.3e-46 157.2 0.1 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS54155.1 - 8.6e-12 44.5 0.1 1.8e-11 43.4 0.1 1.6 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature ABC_membrane PF00664.23 AAS54156.1 - 8.9e-41 140.3 15.4 1.1e-40 140.0 15.4 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 AAS54156.1 - 2.3e-34 118.8 0.0 4.1e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AAS54156.1 - 6.1e-09 35.6 0.2 3.8e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AAS54156.1 - 0.00037 20.2 0.1 0.00094 18.9 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 AAS54156.1 - 0.0011 19.3 0.0 0.0027 18.1 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS54156.1 - 0.0024 18.2 0.1 0.033 14.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_21 PF13304.6 AAS54156.1 - 0.0048 16.8 0.1 0.016 15.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 AAS54156.1 - 0.0099 15.6 0.0 0.027 14.2 0.0 1.8 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 AAS54156.1 - 0.01 14.7 0.2 0.58 8.9 0.1 2.2 2 0 0 2 2 2 0 Predicted ATPase of the ABC class AAA_23 PF13476.6 AAS54156.1 - 0.026 15.0 0.7 0.053 14.0 0.2 1.7 2 0 0 2 2 2 0 AAA domain Gtr1_RagA PF04670.12 AAS54156.1 - 0.057 12.8 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF3987 PF13148.6 AAS54156.1 - 0.064 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) AAA_15 PF13175.6 AAS54156.1 - 0.084 12.6 0.3 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Cytidylate_kin PF02224.18 AAS54156.1 - 0.14 11.9 0.2 0.9 9.2 0.0 2.2 2 0 0 2 2 2 0 Cytidylate kinase GATase_6 PF13522.6 AAS54157.1 - 5.7e-14 52.5 0.0 1.4e-13 51.2 0.0 1.7 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AAS54157.1 - 3.3e-11 43.2 0.0 6.4e-11 42.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 AAS54157.1 - 1e-08 34.9 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 AAS54157.1 - 0.0025 16.8 0.0 0.0044 16.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DLIC PF05783.11 AAS54158.1 - 0.00018 20.5 0.0 0.00032 19.7 0.0 1.3 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) RNase_T PF00929.24 AAS54159.2 - 3.4e-08 34.2 0.0 9.3e-08 32.8 0.0 1.8 1 1 0 1 1 1 1 Exonuclease Methyltransf_22 PF13383.6 AAS54159.2 - 0.039 13.5 0.1 0.068 12.7 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Rtt102p PF09510.10 AAS54160.1 - 9.3e-25 87.3 0.1 2.6e-23 82.7 0.1 2.0 1 1 0 1 1 1 1 Rtt102p-like transcription regulator protein DUF3591 PF12157.8 AAS54161.1 - 7.9e-178 591.6 1.0 7.9e-178 591.6 1.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3591) zf-CCHC_6 PF15288.6 AAS54161.1 - 9.4e-08 31.8 0.8 2.1e-07 30.6 0.8 1.6 1 0 0 1 1 1 1 Zinc knuckle SAP30_Sin3_bdg PF13867.6 AAS54161.1 - 0.083 13.2 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 RT_RNaseH_2 PF17919.1 AAS54162.1 - 0.084 12.9 0.2 7 6.7 0.1 2.2 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Peptidase_S10 PF00450.22 AAS54163.1 - 1.9e-128 429.5 0.1 2.3e-128 429.2 0.1 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Carbpep_Y_N PF05388.11 AAS54163.1 - 0.00024 21.6 0.1 0.00049 20.6 0.1 1.5 1 0 0 1 1 1 1 Carboxypeptidase Y pro-peptide Crisp PF08562.10 AAS54163.1 - 3.1 8.5 4.5 0.72 10.5 0.1 2.0 2 0 0 2 2 2 0 Crisp Peptidase_M20 PF01546.28 AAS54165.1 - 5.1e-09 36.1 0.0 9.3e-09 35.3 0.0 1.5 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 DUF3322 PF11795.8 AAS54165.1 - 0.01 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) DUF4876 PF16215.5 AAS54165.1 - 0.11 12.5 1.3 0.33 10.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4876) Peptidase_M20 PF01546.28 AAS54166.2 - 1.8e-26 93.1 0.0 3.1e-26 92.4 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AAS54166.2 - 6.1e-11 42.2 0.0 2e-10 40.6 0.0 1.9 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AAS54166.2 - 0.00084 19.1 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M28 Proteasome PF00227.26 AAS54167.2 - 3.9e-39 134.1 0.1 2.7e-38 131.4 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit ER_lumen_recept PF00810.18 AAS54168.1 - 5.2e-47 160.4 11.7 5.2e-47 160.4 11.7 1.5 2 0 0 2 2 2 1 ER lumen protein retaining receptor Sod_Cu PF00080.20 AAS54170.2 - 2.1e-47 160.9 3.2 2.4e-47 160.6 3.2 1.0 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) CTP_synth_N PF06418.14 AAS54171.1 - 6.5e-123 409.2 0.0 8.8e-123 408.8 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AAS54171.1 - 6.2e-58 195.7 0.0 9.4e-58 195.1 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AAS54171.1 - 0.027 14.2 0.1 0.19 11.4 0.1 2.3 1 1 0 1 1 1 0 Peptidase C26 CbiA PF01656.23 AAS54171.1 - 0.12 12.4 0.0 0.53 10.3 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain Antimicrobial_1 PF08018.11 AAS54171.1 - 0.26 11.5 1.4 0.59 10.3 1.4 1.6 1 0 0 1 1 1 0 Frog antimicrobial peptide TilS PF09179.11 AAS54172.1 - 0.044 14.3 4.3 0.044 14.3 4.3 3.2 1 1 2 3 3 3 0 TilS substrate binding domain ATP-synt_DE PF00401.20 AAS54172.1 - 0.047 14.0 1.6 0.047 14.0 1.6 2.7 2 0 0 2 2 2 0 ATP synthase, Delta/Epsilon chain, long alpha-helix domain ESCRT-II PF05871.12 AAS54173.1 - 2.6e-36 124.9 0.0 3.7e-36 124.5 0.0 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit Sod_Fe_C PF02777.18 AAS54174.1 - 1.3e-16 60.6 0.5 1.1e-14 54.4 0.5 2.2 1 1 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Peptidase_C12 PF01088.21 AAS54175.2 - 1.4e-51 175.2 0.0 1.8e-51 174.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SAC3_GANP PF03399.16 AAS54176.2 - 6.5e-20 71.7 11.2 7.7e-18 64.9 11.2 2.3 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 AAS54176.2 - 4.5e-05 23.4 1.7 0.00011 22.2 1.7 1.5 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family TPR_MalT PF17874.1 AAS54176.2 - 0.016 14.6 0.1 0.033 13.6 0.1 1.5 1 0 0 1 1 1 0 MalT-like TPR region COX5A PF02284.16 AAS54176.2 - 0.034 14.1 0.1 0.086 12.8 0.1 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va Peptidase_C12 PF01088.21 AAS54177.1 - 7.4e-42 143.5 0.0 8.7e-42 143.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 PX PF00787.24 AAS54178.2 - 3.5e-08 33.4 0.0 6.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 PX domain Mito_carr PF00153.27 AAS54180.2 - 1.2e-70 233.4 0.7 5.9e-23 80.6 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ribosomal_L37ae PF01780.19 AAS54181.1 - 1.8e-40 136.9 8.6 2e-40 136.7 8.6 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Rep_fac-A_C PF08646.10 AAS54181.1 - 0.0036 17.0 0.3 0.0042 16.8 0.3 1.2 1 0 0 1 1 1 1 Replication factor-A C terminal domain zf-RING_13 PF17977.1 AAS54181.1 - 0.007 16.5 2.5 0.0099 16.0 2.5 1.2 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain DUF2175 PF09943.9 AAS54181.1 - 0.012 15.9 0.5 0.71 10.2 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Zn_Tnp_IS1595 PF12760.7 AAS54181.1 - 0.014 15.4 3.0 0.024 14.6 3.0 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 AAS54181.1 - 0.017 15.6 1.0 2.2 8.8 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double domain C1_2 PF03107.16 AAS54181.1 - 0.06 13.7 2.8 0.86 10.0 2.9 2.0 1 1 1 2 2 2 0 C1 domain Elf1 PF05129.13 AAS54181.1 - 0.091 12.8 2.2 0.16 12.1 2.2 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zf-ribbon_3 PF13248.6 AAS54181.1 - 0.11 12.0 2.0 4.5 6.8 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain CarbpepA_inh PF02977.15 AAS54181.1 - 0.11 12.3 3.9 0.14 12.0 0.8 2.1 1 1 1 2 2 2 0 Carboxypeptidase A inhibitor zf-C4_ClpX PF06689.13 AAS54181.1 - 0.12 12.2 2.8 0.24 11.3 0.2 2.3 2 0 0 2 2 2 0 ClpX C4-type zinc finger YyzF PF14116.6 AAS54181.1 - 0.58 10.2 0.2 0.58 10.2 0.2 1.8 2 0 0 2 2 2 0 YyzF-like protein Beta-TrCP_D PF12125.8 AAS54183.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 D domain of beta-TrCP Fip1 PF05182.13 AAS54184.1 - 1.3e-22 79.0 0.4 2.2e-22 78.3 0.4 1.4 1 0 0 1 1 1 1 Fip1 motif PIEZO PF15917.5 AAS54184.1 - 0.16 11.4 1.0 0.22 11.0 1.0 1.2 1 0 0 1 1 1 0 Piezo DNA_pol_phi PF04931.13 AAS54184.1 - 0.18 9.9 8.9 0.23 9.5 8.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 AAS54184.1 - 1.2 7.6 13.9 5.4 5.5 14.8 1.6 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 AAS54184.1 - 1.8 6.7 16.0 2.2 6.4 16.0 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 AAS54184.1 - 2.5 7.3 14.5 3.8 6.8 14.5 1.2 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 AAS54184.1 - 9.4 6.3 13.8 0.42 10.7 8.5 1.5 2 0 0 2 2 2 0 YL1 nuclear protein PH PF00169.29 AAS54185.1 - 1.6e-07 31.7 1.2 3.4e-07 30.7 0.1 2.2 2 0 0 2 2 2 1 PH domain PUF PF00806.19 AAS54186.2 - 1.6e-29 99.9 1.0 0.00032 20.2 0.0 6.8 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat RRM_1 PF00076.22 AAS54186.2 - 3.1e-06 26.9 0.0 6.2e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MAM1 PF10434.9 AAS54187.1 - 3.1e-73 246.7 0.7 4.4e-73 246.2 0.7 1.1 1 0 0 1 1 1 1 Monopolin complex protein MAM1 MsyB PF13984.6 AAS54187.1 - 0.066 13.5 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 MsyB protein Pfg27 PF09216.10 AAS54187.1 - 0.11 12.3 0.2 0.21 11.4 0.2 1.3 1 0 0 1 1 1 0 Pfg27 GatB_N PF02934.15 AAS54188.1 - 1.3e-91 306.8 0.0 1.6e-91 306.5 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AAS54188.1 - 3e-33 114.8 0.0 5.1e-33 114.0 0.0 1.3 1 0 0 1 1 1 1 GatB domain DUF5349 PF17298.2 AAS54189.1 - 1.2e-25 91.1 33.0 2.2e-15 57.3 0.0 2.8 2 1 0 2 2 2 2 Family of unknown function (DUF5349) WD40 PF00400.32 AAS54190.1 - 6.4e-20 71.1 5.2 6e-05 23.7 0.3 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54190.1 - 2.3e-09 37.4 0.0 0.18 12.2 0.0 4.6 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS54190.1 - 7.2e-05 21.6 0.8 0.1 11.2 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 AAS54190.1 - 0.0033 16.8 0.0 0.0056 16.0 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 AAS54190.1 - 0.0061 15.6 0.1 0.051 12.5 0.0 2.3 2 0 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein LisH PF08513.11 AAS54191.2 - 4.1e-08 32.9 0.5 7e-08 32.2 0.5 1.4 1 0 0 1 1 1 1 LisH LMBR1 PF04791.16 AAS54191.2 - 2.2 7.1 17.1 5.6 5.8 17.3 1.7 2 0 0 2 2 2 0 LMBR1-like membrane protein Caldesmon PF02029.15 AAS54191.2 - 3.2 6.4 50.8 6.5 5.4 50.8 1.5 1 0 0 1 1 1 0 Caldesmon ALG3 PF05208.13 AAS54192.2 - 2.1e-131 438.6 15.5 2.5e-131 438.4 15.5 1.0 1 0 0 1 1 1 1 ALG3 protein HEAT_EZ PF13513.6 AAS54193.2 - 3.6e-18 65.7 2.5 0.0035 17.8 0.1 8.1 7 0 0 7 7 7 4 HEAT-like repeat HEAT PF02985.22 AAS54193.2 - 2e-11 43.1 6.0 0.38 11.1 0.0 8.5 9 0 0 9 9 7 3 HEAT repeat HEAT_2 PF13646.6 AAS54193.2 - 1e-10 41.8 6.4 0.014 15.7 0.1 6.8 6 2 2 8 8 8 3 HEAT repeats IBN_N PF03810.19 AAS54193.2 - 1.9e-10 40.5 7.4 2e-08 34.0 0.0 4.7 5 1 0 5 5 4 2 Importin-beta N-terminal domain Cnd1 PF12717.7 AAS54193.2 - 1.1e-07 32.0 5.7 0.088 12.8 0.4 5.2 5 2 0 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 AAS54193.2 - 6.4e-07 29.9 5.3 2.1 9.0 0.0 6.5 5 1 1 6 6 6 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 AAS54193.2 - 3.5e-05 23.5 4.7 4.6 6.7 0.0 6.0 6 0 0 6 6 6 2 CLASP N terminal DUF3385 PF11865.8 AAS54193.2 - 0.00016 21.6 12.0 0.72 9.8 0.0 7.1 7 4 1 8 8 8 2 Domain of unknown function (DUF3385) Sec7_N PF12783.7 AAS54193.2 - 0.00031 20.7 1.5 0.01 15.7 0.1 3.7 2 2 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Tti2 PF10521.9 AAS54193.2 - 0.017 14.7 0.6 1.2 8.6 0.1 3.1 2 0 0 2 2 2 0 Tti2 family PAD_M PF08527.10 AAS54193.2 - 0.024 14.3 0.1 0.15 11.7 0.1 2.2 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain DUF1840 PF08895.11 AAS54193.2 - 0.065 13.6 0.0 0.46 10.8 0.0 2.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) RTP1_C1 PF10363.9 AAS54193.2 - 0.068 13.4 1.1 2.9 8.1 0.1 3.8 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ank_4 PF13637.6 AAS54194.1 - 5e-07 30.1 3.9 0.00087 19.8 0.3 3.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) KilA-N PF04383.13 AAS54194.1 - 9.8e-07 28.6 0.2 9.6e-06 25.4 0.2 2.6 1 1 0 1 1 1 1 KilA-N domain Ank_2 PF12796.7 AAS54194.1 - 3.3e-05 24.4 0.3 0.24 12.0 0.0 2.9 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 AAS54194.1 - 0.0015 18.8 0.3 2 8.9 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 AAS54194.1 - 0.0018 18.6 1.3 3.4 8.3 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 AAS54194.1 - 0.0055 17.1 3.7 0.31 11.7 0.1 3.8 4 0 0 4 4 4 1 Ankyrin repeat TPD52 PF04201.15 AAS54194.1 - 0.021 14.5 0.8 0.05 13.2 0.8 1.6 1 0 0 1 1 1 0 Tumour protein D52 family LSM PF01423.22 AAS54195.1 - 7e-15 54.5 0.1 7e-15 54.5 0.1 1.5 2 0 0 2 2 2 1 LSM domain SM-ATX PF14438.6 AAS54195.1 - 0.00088 19.4 0.0 0.0015 18.6 0.0 1.4 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AAS54195.1 - 0.064 13.4 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Scd6-like Sm domain GRP PF07172.11 AAS54195.1 - 0.85 10.3 19.3 1.5 9.6 19.3 1.4 1 0 0 1 1 1 0 Glycine rich protein family EMP70 PF02990.16 AAS54196.1 - 2.2e-60 204.8 2.1 9.8e-60 202.7 2.1 1.8 1 1 0 1 1 1 1 Endomembrane protein 70 TPR_2 PF07719.17 AAS54197.1 - 3.9e-43 142.1 7.3 1.7e-07 30.8 0.1 10.0 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_1 PF00515.28 AAS54197.1 - 1.8e-36 122.5 15.7 4.1e-08 32.7 0.1 8.7 11 0 0 11 11 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54197.1 - 1.3e-33 112.3 5.1 6.6e-05 22.8 0.4 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS54197.1 - 2.7e-33 114.0 25.1 4.4e-20 71.7 3.6 4.7 5 1 1 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 AAS54197.1 - 1.4e-25 88.6 11.1 1.6e-05 24.5 0.1 6.8 1 1 5 6 6 6 5 TPR repeat TPR_14 PF13428.6 AAS54197.1 - 1.1e-20 72.5 2.3 0.0042 17.8 0.0 8.5 5 3 4 9 9 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 AAS54197.1 - 1.4e-19 69.0 18.0 6.8e-05 23.0 0.4 8.3 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54197.1 - 5.4e-19 68.3 9.8 0.00015 22.0 0.3 8.2 5 2 2 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54197.1 - 8e-19 68.0 0.5 4.2e-05 24.1 0.0 5.9 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS54197.1 - 2.9e-18 66.2 3.3 4.8e-05 23.8 0.0 6.1 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 AAS54197.1 - 5.3e-13 48.0 2.7 0.76 9.9 0.1 7.7 6 1 1 7 7 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 AAS54197.1 - 2.3e-12 46.7 19.2 0.074 13.7 0.0 9.8 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_15 PF13429.6 AAS54197.1 - 3.2e-11 43.0 3.2 0.00042 19.6 0.0 4.9 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 AAS54197.1 - 3.7e-06 27.0 0.0 0.021 15.0 0.0 3.6 2 2 2 4 4 4 2 Tetratricopeptide repeat DUF3856 PF12968.7 AAS54197.1 - 0.00011 22.2 0.3 0.62 10.1 0.1 5.1 3 1 1 4 4 4 1 Domain of Unknown Function (DUF3856) BTAD PF03704.17 AAS54197.1 - 0.0012 19.3 0.0 0.7 10.3 0.0 2.9 2 1 1 3 3 2 1 Bacterial transcriptional activator domain TPR_10 PF13374.6 AAS54197.1 - 0.0053 16.6 7.1 12 5.9 0.0 6.8 8 0 0 8 8 8 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 AAS54197.1 - 0.013 15.2 0.0 35 4.0 0.0 4.3 3 1 1 5 5 5 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_4 PF07721.14 AAS54197.1 - 0.014 16.0 3.0 4.3 8.2 0.0 4.6 6 0 0 6 6 3 0 Tetratricopeptide repeat TPR_21 PF09976.9 AAS54197.1 - 0.015 15.0 0.2 1.3 8.6 0.2 2.9 1 1 2 3 3 3 0 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 AAS54197.1 - 0.038 14.0 5.4 0.16 12.0 0.0 3.7 4 1 0 4 4 3 0 Putative TPR-like repeat TPR_20 PF14561.6 AAS54197.1 - 0.053 13.8 0.2 18 5.7 0.0 3.6 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 AAS54197.1 - 0.23 11.5 18.0 1.4 9.0 0.0 5.4 6 0 0 6 6 6 0 Tetratricopeptide repeat IlvGEDA_leader PF08046.11 AAS54197.1 - 0.34 10.4 0.9 0.64 9.5 0.9 1.5 1 0 0 1 1 1 0 IlvGEDA operon leader peptide Fis1_TPR_C PF14853.6 AAS54197.1 - 0.36 10.9 13.7 8.8 6.5 0.0 5.8 5 2 2 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 AAS54197.1 - 7.1 7.1 7.9 26 5.3 0.0 4.1 5 0 0 5 5 3 0 PPR repeat PH PF00169.29 AAS54198.1 - 1.8e-16 60.5 0.0 4.9e-16 59.2 0.0 1.7 1 0 0 1 1 1 1 PH domain SH3_1 PF00018.28 AAS54198.1 - 1.4e-13 50.2 0.2 2.8e-13 49.2 0.2 1.6 1 0 0 1 1 1 1 SH3 domain SAM_2 PF07647.17 AAS54198.1 - 4.4e-12 45.9 0.1 7.4e-12 45.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SH3_9 PF14604.6 AAS54198.1 - 6.9e-09 35.4 0.1 1.3e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Variant SH3 domain SAM_1 PF00536.30 AAS54198.1 - 3e-05 24.4 0.0 5e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH_8 PF15409.6 AAS54198.1 - 0.00037 20.7 0.0 0.012 15.9 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 AAS54198.1 - 0.00085 19.7 0.2 0.011 16.1 0.1 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain SH3_2 PF07653.17 AAS54198.1 - 0.0034 17.0 0.0 0.01 15.5 0.0 1.8 1 0 0 1 1 1 1 Variant SH3 domain BORCS8 PF10167.9 AAS54198.1 - 0.043 13.8 0.1 0.11 12.4 0.1 1.7 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 8 SAM_PNT PF02198.16 AAS54198.1 - 0.12 12.4 0.0 0.31 11.0 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain NT-C2 PF10358.9 AAS54200.1 - 2.5e-41 140.8 0.0 4.6e-41 139.9 0.0 1.4 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins ABC_trans_aux PF03886.13 AAS54200.1 - 0.076 12.6 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 ABC-type transport auxiliary lipoprotein component zf-C3HC4 PF00097.25 AAS54202.1 - 4.3e-10 39.3 5.5 6.8e-10 38.7 5.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS54202.1 - 1.7e-09 37.4 5.2 2.4e-09 36.9 5.2 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS54202.1 - 7.9e-08 32.2 4.1 1.4e-07 31.4 4.1 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AAS54202.1 - 2.2e-07 30.7 6.3 3.5e-07 30.1 6.3 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 AAS54202.1 - 1.6e-06 28.3 6.0 2.6e-06 27.7 6.0 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS54202.1 - 5.7e-05 22.9 7.8 0.00014 21.6 7.9 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 AAS54202.1 - 7.7e-05 22.5 7.1 0.00024 20.9 6.0 2.0 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 AAS54202.1 - 0.0032 17.5 2.0 0.0054 16.7 2.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger FBP_C PF16571.5 AAS54202.1 - 0.0047 16.5 0.5 0.0079 15.7 0.5 1.4 1 0 0 1 1 1 1 FBP C-terminal treble-clef zinc-finger zf-C3HC4_4 PF15227.6 AAS54202.1 - 0.0053 16.9 7.7 0.009 16.1 7.7 1.4 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 AAS54202.1 - 0.01 16.1 4.6 0.017 15.4 4.6 1.3 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_11 PF17123.5 AAS54202.1 - 0.081 12.7 5.0 0.82 9.5 0.6 3.2 3 0 0 3 3 3 0 RING-like zinc finger zf-RING_4 PF14570.6 AAS54202.1 - 2.7 7.9 8.6 8.1 6.3 7.7 2.0 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Ribosomal_L14 PF00238.19 AAS54203.1 - 2.6e-33 114.7 0.0 3.1e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e PI3_PI4_kinase PF00454.27 AAS54204.1 - 5e-56 190.3 0.1 1.6e-55 188.6 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase TAN PF11640.8 AAS54204.1 - 6e-19 68.7 0.4 5.4e-18 65.6 0.1 3.0 2 0 0 2 2 2 1 Telomere-length maintenance and DNA damage repair FATC PF02260.20 AAS54204.1 - 4.3e-10 39.2 0.0 1.1e-09 37.9 0.0 1.8 1 0 0 1 1 1 1 FATC domain SYCP2_ARLD PF18581.1 AAS54204.1 - 0.047 13.7 0.7 1.4 8.9 0.0 3.0 2 0 0 2 2 2 0 Synaptonemal complex 2 armadillo-repeat-like domain PhageMin_Tail PF10145.9 AAS54204.1 - 0.053 13.4 3.2 0.12 12.2 3.2 1.5 1 0 0 1 1 1 0 Phage-related minor tail protein DUF2267 PF10025.9 AAS54204.1 - 0.17 12.2 0.1 0.44 10.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) CNOT11 PF10155.9 AAS54204.1 - 2.2 8.4 7.6 5.1 7.3 0.1 4.4 4 0 0 4 4 4 0 CCR4-NOT transcription complex subunit 11 SH3_1 PF00018.28 AAS54205.1 - 9.2e-11 41.2 0.1 1.7e-10 40.3 0.1 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS54205.1 - 2.5e-10 40.1 0.0 4.3e-10 39.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS54205.1 - 3.9e-08 32.9 0.0 7.6e-08 31.9 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain DUF4181 PF13789.6 AAS54205.1 - 0.12 12.6 0.8 0.2 11.9 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) SH3_10 PF17902.1 AAS54205.1 - 0.17 12.0 0.0 0.37 10.9 0.0 1.5 1 0 0 1 1 1 0 SH3 domain Aa_trans PF01490.18 AAS54206.2 - 7.7e-96 321.3 9.1 9e-96 321.1 9.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 AAS54206.2 - 3.4e-05 23.1 10.7 7.2e-05 22.0 10.7 1.5 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Ribosomal_S21 PF01165.20 AAS54207.2 - 1e-10 41.1 3.7 1e-10 41.1 3.7 1.7 2 0 0 2 2 2 1 Ribosomal protein S21 CaMBD PF02888.16 AAS54207.2 - 0.85 9.9 5.6 0.38 11.0 1.6 2.1 1 1 1 2 2 2 0 Calmodulin binding domain Peptidase_M24 PF00557.24 AAS54208.2 - 4.6e-47 160.4 0.1 5.8e-47 160.1 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Motile_Sperm PF00635.26 AAS54209.1 - 3.8e-25 87.9 0.4 7.6e-25 86.9 0.1 1.6 1 1 1 2 2 2 1 MSP (Major sperm protein) domain TMEM131_like PF12371.8 AAS54209.1 - 0.004 17.4 0.1 0.0065 16.7 0.1 1.3 1 0 0 1 1 1 1 Transmembrane protein 131-like DUF4693 PF15764.5 AAS54209.1 - 0.029 14.0 0.0 0.051 13.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4693) ASH PF15780.5 AAS54209.1 - 0.099 12.9 0.1 0.22 11.8 0.1 1.6 1 1 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Ribosomal_L32e PF01655.18 AAS54210.1 - 2.1e-47 160.0 2.2 2.4e-47 159.8 2.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L32 Rox3 PF08633.10 AAS54211.1 - 2.4e-39 135.8 0.0 2.8e-39 135.5 0.0 1.1 1 0 0 1 1 1 1 Rox3 mediator complex subunit PPIP5K2_N PF18086.1 AAS54211.1 - 0.098 12.8 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain ArfGap PF01412.18 AAS54212.1 - 8.8e-35 119.3 0.2 2.3e-34 118.0 0.2 1.7 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf 4HBT PF03061.22 AAS54213.1 - 2e-07 31.3 0.0 3.6e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily Sugar_tr PF00083.24 AAS54214.1 - 5.6e-79 266.1 28.7 7e-79 265.8 28.7 1.0 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 AAS54214.1 - 2.3e-13 49.8 53.8 5.9e-12 45.2 21.0 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily UPF0715 PF17094.5 AAS54214.1 - 0.00019 22.0 5.7 0.0014 19.2 5.9 2.5 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0715) FAD_binding_3 PF01494.19 AAS54215.1 - 1.7e-18 67.0 0.0 4.2e-18 65.7 0.0 1.6 1 1 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 AAS54215.1 - 1.4e-05 25.2 0.1 3e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AAS54215.1 - 2.1e-05 24.3 0.0 8.2e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 AAS54215.1 - 2.7e-05 24.7 0.0 5.8e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AAS54215.1 - 4.9e-05 22.6 0.0 6.2e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 AAS54215.1 - 0.00012 21.5 0.1 0.00038 19.8 0.0 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AAS54215.1 - 0.00012 22.0 0.0 0.00021 21.2 0.0 1.4 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain SE PF08491.10 AAS54215.1 - 0.0017 17.5 0.1 0.021 13.9 0.0 2.1 2 0 0 2 2 2 1 Squalene epoxidase FAD_binding_2 PF00890.24 AAS54215.1 - 0.005 16.0 0.1 0.0099 15.0 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain ApbA PF02558.16 AAS54215.1 - 0.0091 15.6 0.0 0.021 14.5 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA HI0933_like PF03486.14 AAS54215.1 - 0.019 13.7 0.0 0.029 13.1 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein UDPG_MGDP_dh_N PF03721.14 AAS54215.1 - 0.025 14.2 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 AAS54215.1 - 0.043 13.1 0.1 0.078 12.3 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.15 AAS54215.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase FAD_oxidored PF12831.7 AAS54215.1 - 0.17 11.2 0.1 0.34 10.2 0.1 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_Gly3P_dh_N PF01210.23 AAS54215.1 - 0.2 11.7 0.0 0.37 10.7 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Cnd2 PF05786.14 AAS54216.1 - 8.8e-140 467.8 22.3 2e-108 364.1 19.6 2.4 1 1 1 2 2 2 2 Condensin complex subunit 2 CNDH2_N PF06278.11 AAS54216.1 - 0.00058 20.0 0.6 0.0054 16.9 0.0 2.5 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal UvrD-helicase PF00580.21 AAS54216.1 - 0.096 12.2 0.3 0.3 10.6 0.2 1.9 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Peptidase_M41 PF01434.18 AAS54217.1 - 6.3e-61 205.6 0.1 1.3e-60 204.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase family M41 AAA PF00004.29 AAS54217.1 - 5e-41 140.2 0.0 1.8e-40 138.5 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS54217.1 - 6.4e-08 32.3 0.0 2.7e-07 30.3 0.0 2.2 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 AAS54217.1 - 7.4e-06 26.4 0.2 8e-05 23.1 0.2 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS54217.1 - 0.00024 21.4 0.2 0.14 12.4 0.1 3.1 2 1 0 3 3 3 1 AAA domain TIP49 PF06068.13 AAS54217.1 - 0.00052 19.3 0.0 0.0011 18.2 0.0 1.6 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_5 PF07728.14 AAS54217.1 - 0.0023 17.9 0.1 0.0083 16.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.12 AAS54217.1 - 0.0024 17.6 0.0 0.007 16.1 0.0 1.8 2 0 0 2 2 1 1 Holliday junction DNA helicase RuvB P-loop domain ATPase PF06745.13 AAS54217.1 - 0.015 14.6 0.6 0.57 9.5 0.0 2.9 3 0 0 3 3 3 0 KaiC IstB_IS21 PF01695.17 AAS54217.1 - 0.021 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_25 PF13481.6 AAS54217.1 - 0.028 14.0 0.7 1.1 8.8 0.3 2.6 1 1 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AAS54217.1 - 0.03 14.5 0.0 0.19 11.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 AAS54217.1 - 0.05 13.0 0.1 0.11 11.9 0.1 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 AAS54217.1 - 0.084 13.4 0.3 0.36 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_2 PF07724.14 AAS54217.1 - 0.095 12.8 0.0 0.34 11.0 0.0 2.0 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) TsaE PF02367.17 AAS54217.1 - 0.099 12.7 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Peptidase_M50B PF13398.6 AAS54217.1 - 0.23 11.1 1.0 1.2 8.7 0.0 2.2 2 0 0 2 2 2 0 Peptidase M50B-like Cyclin_C_2 PF16899.5 AAS54218.1 - 4.4e-28 97.7 3.4 1.8e-27 95.7 1.2 2.5 2 1 0 2 2 2 1 Cyclin C-terminal domain Cyclin_N PF00134.23 AAS54218.1 - 1.9e-07 30.9 0.4 3.9e-07 29.9 0.4 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain UvsY PF11056.8 AAS54218.1 - 0.003 17.9 0.1 0.0077 16.6 0.1 1.6 1 0 0 1 1 1 1 Recombination, repair and ssDNA binding protein UvsY TFIIB PF00382.19 AAS54218.1 - 0.0051 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 Transcription factor TFIIB repeat ATP-synt_ab PF00006.25 AAS54219.1 - 8.7e-73 244.5 0.0 1.4e-72 243.8 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.27 AAS54219.1 - 8.7e-47 158.6 1.1 1.6e-46 157.7 1.1 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.23 AAS54219.1 - 1.5e-16 60.7 2.4 4.3e-16 59.2 2.4 1.8 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain Tex_N PF09371.10 AAS54219.1 - 0.083 12.6 0.0 0.2 11.3 0.0 1.6 1 0 0 1 1 1 0 Tex-like protein N-terminal domain Glyco_hydro_65m PF03632.15 AAS54220.1 - 5.6e-35 120.9 2.3 1.6e-31 109.5 0.2 2.2 1 1 1 2 2 2 2 Glycosyl hydrolase family 65 central catalytic domain Glyco_hydro_65N PF03636.15 AAS54220.1 - 3.2e-23 82.6 0.0 5.6e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 65, N-terminal domain Glyco_hydro_65C PF03633.15 AAS54220.1 - 1.1e-05 25.2 0.8 5.2e-05 23.1 0.0 2.6 3 0 0 3 3 3 1 Glycosyl hydrolase family 65, C-terminal domain F5_F8_type_C PF00754.25 AAS54220.1 - 0.0045 17.1 0.2 0.042 14.0 0.0 2.7 3 0 0 3 3 3 1 F5/8 type C domain INCENP_ARK-bind PF03941.15 AAS54222.1 - 6.3e-17 61.3 0.1 1.5e-16 60.0 0.1 1.7 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region TPR_1 PF00515.28 AAS54223.1 - 1.8e-13 49.7 5.3 8.1e-06 25.4 1.7 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 AAS54223.1 - 5.3e-11 41.8 3.6 0.00023 21.0 0.8 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 AAS54223.1 - 5.2e-06 26.0 0.3 0.00028 20.5 0.0 3.0 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 AAS54223.1 - 4.3e-05 23.4 0.4 0.21 11.9 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54223.1 - 5.7e-05 23.7 0.1 0.0074 16.9 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS54223.1 - 8.1e-05 22.8 0.2 0.00019 21.6 0.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 AAS54223.1 - 0.00055 20.2 0.1 0.58 10.5 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 AAS54223.1 - 0.00075 19.7 1.1 0.011 16.1 0.0 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 AAS54223.1 - 0.0027 18.4 0.5 0.6 11.1 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS54223.1 - 0.0035 17.8 0.4 0.012 16.1 0.2 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat PACT_coil_coil PF10495.9 AAS54223.1 - 0.082 13.5 2.0 0.21 12.2 2.0 1.7 1 0 0 1 1 1 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein TPR_6 PF13174.6 AAS54223.1 - 0.19 12.4 0.5 17 6.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AAS54223.1 - 0.25 11.4 4.3 9.3 6.4 0.0 2.9 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Borrelia_REV PF03978.13 AAS54223.1 - 0.42 10.5 4.6 2.1 8.3 0.2 2.2 1 1 1 2 2 2 0 Borrelia burgdorferi REV protein Glyco_transf_15 PF01793.16 AAS54224.1 - 2.2e-134 447.8 8.4 2.7e-134 447.5 8.4 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase MIP PF00230.20 AAS54225.2 - 3.7e-45 154.4 15.4 4.6e-45 154.1 15.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein DUF3810 PF12725.7 AAS54225.2 - 0.27 10.5 1.1 13 5.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF2070 PF09843.9 AAS54225.2 - 0.94 7.7 6.7 3.9 5.6 2.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) ODC_AZ PF02100.17 AAS54226.2 - 3.9e-08 33.3 0.1 6.1e-08 32.6 0.1 1.4 1 1 0 1 1 1 1 Ornithine decarboxylase antizyme NUP PF06516.11 AAS54226.2 - 0.15 11.3 0.1 0.23 10.7 0.1 1.2 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) OrfB_Zn_ribbon PF07282.11 AAS54227.1 - 4e-16 58.7 1.7 8.8e-16 57.6 1.7 1.6 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.19 AAS54227.1 - 3.3e-08 33.8 1.2 1.2e-07 32.0 1.2 2.0 1 0 0 1 1 1 1 Probable transposase HTH_OrfB_IS605 PF12323.8 AAS54227.1 - 9e-08 31.5 0.0 2e-07 30.4 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain C1_2 PF03107.16 AAS54227.1 - 0.063 13.6 1.6 0.12 12.7 1.6 1.5 1 0 0 1 1 1 0 C1 domain cwf21 PF08312.12 AAS54228.1 - 5e-12 45.8 12.3 8.2e-12 45.1 12.3 1.3 1 0 0 1 1 1 1 cwf21 domain DHR10 PF18595.1 AAS54228.1 - 0.001 19.1 6.7 0.001 19.1 6.7 1.6 1 1 0 1 1 1 1 Designed helical repeat protein 10 domain GvpG PF05120.12 AAS54228.1 - 0.0011 18.9 2.1 0.0018 18.2 2.1 1.3 1 0 0 1 1 1 1 Gas vesicle protein G MPS2 PF17060.5 AAS54228.1 - 0.0076 15.6 1.2 0.0081 15.5 1.2 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 LMP PF04778.12 AAS54228.1 - 0.0087 16.0 0.2 0.012 15.5 0.2 1.3 1 1 0 1 1 1 1 LMP repeated region Lebercilin PF15619.6 AAS54228.1 - 0.067 12.8 7.1 0.085 12.5 7.1 1.2 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease GTP-bdg_M PF16360.5 AAS54228.1 - 0.091 13.4 9.2 0.2 12.3 1.0 2.3 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Trans_reg_C PF00486.28 AAS54228.1 - 0.17 12.0 1.2 0.35 11.0 0.3 1.8 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal DUF2559 PF10832.8 AAS54228.1 - 0.71 10.0 6.0 0.74 9.9 1.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2559) Spc7 PF08317.11 AAS54228.1 - 1 8.2 6.1 1.6 7.6 6.1 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein Nbl1_Borealin_N PF10444.9 AAS54228.1 - 3.4 7.4 7.9 4.5 7.0 3.3 2.4 1 1 1 2 2 2 0 Nbl1 / Borealin N terminal Troponin PF00992.20 AAS54228.1 - 5.2 7.4 10.6 9.5 6.5 10.6 1.6 1 1 0 1 1 1 0 Troponin Arf PF00025.21 AAS54230.1 - 1.7e-46 157.9 0.1 2.2e-46 157.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 AAS54230.1 - 3.4e-13 49.5 0.0 4.1e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Ras family G-alpha PF00503.20 AAS54230.1 - 7.6e-13 48.3 0.0 2.7e-07 30.1 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 AAS54230.1 - 6.9e-12 45.7 0.0 1.1e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AAS54230.1 - 1.8e-10 40.6 0.0 2.1e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AAS54230.1 - 1.7e-06 27.8 0.0 0.00026 20.6 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 AAS54230.1 - 1.9e-06 27.4 0.0 2.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 AAS54230.1 - 5.8e-05 23.1 0.0 9.7e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 AAS54230.1 - 0.13 12.5 0.1 1.1 9.6 0.0 2.3 1 1 1 2 2 2 0 AAA domain Alk_phosphatase PF00245.20 AAS54231.1 - 2.2e-113 379.4 0.4 2.5e-113 379.2 0.4 1.0 1 0 0 1 1 1 1 Alkaline phosphatase Metalloenzyme PF01676.18 AAS54231.1 - 0.0017 17.8 0.2 0.0058 16.0 0.4 1.8 2 1 0 2 2 2 1 Metalloenzyme superfamily Anp1 PF03452.14 AAS54232.2 - 7.7e-101 336.9 0.0 9.4e-101 336.7 0.0 1.1 1 0 0 1 1 1 1 Anp1 Glycos_transf_2 PF00535.26 AAS54232.2 - 0.00055 19.8 0.0 0.0075 16.1 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 GST_N PF02798.20 AAS54234.2 - 7.5e-10 39.0 0.0 1.6e-09 37.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 AAS54234.2 - 1.2e-08 35.1 0.1 2.2e-08 34.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AAS54234.2 - 5.8e-08 32.6 2.0 1.2e-07 31.6 2.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 AAS54234.2 - 0.0019 18.3 0.0 0.0032 17.6 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Catalase PF00199.19 AAS54235.1 - 2.6e-182 606.2 0.2 3.3e-182 605.8 0.2 1.1 1 0 0 1 1 1 1 Catalase Catalase-rel PF06628.12 AAS54235.1 - 6e-11 42.4 0.0 2e-10 40.7 0.0 1.9 2 0 0 2 2 2 1 Catalase-related immune-responsive Sgf11_N PF18519.1 AAS54236.1 - 1.2e-21 76.0 1.2 1.5e-21 75.6 1.2 1.2 1 0 0 1 1 1 1 SAGA-associated factor 11 N-terminal domain Sgf11 PF08209.11 AAS54236.1 - 2e-17 62.4 3.9 3.2e-17 61.8 3.9 1.3 1 0 0 1 1 1 1 Sgf11 (transcriptional regulation protein) zf_Rg PF17915.1 AAS54236.1 - 0.0099 15.3 0.1 0.018 14.4 0.1 1.4 1 0 0 1 1 1 1 Reverse gyrase zinc finger zf-Di19 PF05605.12 AAS54236.1 - 0.047 14.0 0.1 0.076 13.3 0.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding DUF1610 PF07754.11 AAS54236.1 - 0.056 13.4 1.1 0.11 12.5 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) CLTH PF10607.9 AAS54237.1 - 2.8e-11 43.5 0.9 3e-10 40.2 0.3 2.3 2 1 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain zf-RING_UBOX PF13445.6 AAS54237.1 - 0.0015 18.5 3.4 0.0031 17.5 3.4 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 AAS54237.1 - 0.043 13.8 2.6 0.099 12.6 2.6 1.6 1 0 0 1 1 1 0 zinc-RING finger domain LRRFIP PF09738.9 AAS54237.1 - 0.052 13.0 0.8 0.08 12.4 0.8 1.2 1 0 0 1 1 1 0 LRRFIP family DUF4083 PF13314.6 AAS54237.1 - 0.074 13.0 0.1 0.21 11.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) zf-RING_2 PF13639.6 AAS54237.1 - 0.43 11.0 5.7 0.29 11.5 3.6 1.9 2 0 0 2 2 2 0 Ring finger domain Skp1_POZ PF03931.15 AAS54238.1 - 1.7e-16 60.1 0.0 3.3e-16 59.2 0.0 1.5 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 AAS54238.1 - 0.0047 17.1 0.3 0.0079 16.4 0.3 1.4 1 1 0 1 1 1 1 BTB/POZ domain DUF1344 PF07076.11 AAS54238.1 - 0.1 12.5 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1344) Vps16_C PF04840.12 AAS54239.1 - 2.8e-80 269.8 6.8 5.8e-80 268.7 6.8 1.5 1 0 0 1 1 1 1 Vps16, C-terminal region Vps16_N PF04841.13 AAS54239.1 - 2.9e-61 207.4 0.0 4.2e-61 206.9 0.0 1.2 1 0 0 1 1 1 1 Vps16, N-terminal region CENP-N PF05238.13 AAS54240.2 - 9e-86 288.8 0.0 1.1e-85 288.5 0.0 1.1 1 0 0 1 1 1 1 Kinetochore protein CHL4 like DUF5001 PF16392.5 AAS54240.2 - 0.17 11.8 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 Ig-like domain RRM_1 PF00076.22 AAS54241.1 - 2.2e-57 190.8 0.9 7.5e-19 67.3 0.1 5.1 5 0 0 5 5 5 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS54241.1 - 2.2e-08 34.1 0.4 0.0017 18.4 0.0 4.1 4 1 0 4 4 4 2 RNA recognition motif PHM7_cyt PF14703.6 AAS54241.1 - 0.00054 20.2 12.7 2.2 8.5 0.0 6.5 4 4 2 6 6 6 2 Cytosolic domain of 10TM putative phosphate transporter RRM_Rrp7 PF17799.1 AAS54241.1 - 0.0031 17.3 9.5 0.45 10.3 0.0 4.4 4 1 1 5 5 5 3 Rrp7 RRM-like N-terminal domain Pkinase PF00069.25 AAS54242.2 - 3.6e-56 190.5 0.3 3e-54 184.2 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54242.2 - 9.9e-27 93.8 0.3 1.6e-24 86.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS54242.2 - 0.0046 16.0 0.2 0.0085 15.1 0.2 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Imm7 PF15585.6 AAS54242.2 - 0.036 14.3 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 7 FLILHELTA PF10306.9 AAS54243.1 - 4e-14 52.8 0.0 6.9e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Hypothetical protein FLILHELTA tRNA-synt_1 PF00133.22 AAS54244.1 - 1.3e-148 496.0 0.0 2.1e-148 495.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AAS54244.1 - 9.1e-20 70.8 0.1 3.5e-11 42.5 0.0 3.2 3 0 0 3 3 3 3 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AAS54244.1 - 5e-19 68.8 0.0 1.1e-18 67.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1_2 PF13603.6 AAS54244.1 - 0.017 14.6 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1e PF01406.19 AAS54244.1 - 0.15 11.4 0.0 15 4.8 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain zf-FPG_IleRS PF06827.14 AAS54244.1 - 0.47 10.4 5.8 1.4 8.8 5.8 1.9 1 1 0 1 1 1 0 Zinc finger found in FPG and IleRS zf-C2H2 PF00096.26 AAS54245.1 - 1.5e-08 34.7 6.3 0.0016 18.8 2.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS54245.1 - 4.1e-08 33.4 4.9 0.0044 17.7 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AAS54245.1 - 0.0061 16.5 2.2 1.7 8.8 0.1 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AAS54245.1 - 0.0063 16.2 3.9 1 9.2 0.2 2.5 2 0 0 2 2 2 2 zinc-finger C2H2-type zf-met PF12874.7 AAS54245.1 - 0.017 15.5 0.2 0.78 10.2 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 AAS54245.1 - 0.019 15.4 5.0 0.2 12.1 0.6 3.2 3 1 0 3 3 3 0 Zinc-finger double domain zf-C2H2_jaz PF12171.8 AAS54245.1 - 0.024 14.9 0.3 0.5 10.7 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding NAC PF01849.18 AAS54246.1 - 6e-17 61.4 0.2 1.1e-16 60.5 0.2 1.5 1 0 0 1 1 1 1 NAC domain ApbA_C PF08546.11 AAS54247.1 - 2.8e-06 27.5 0.0 5.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal DUF3896 PF13035.6 AAS54247.1 - 0.25 11.5 1.5 17 5.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3896) V-SNARE PF05008.15 AAS54247.1 - 7.9 6.9 9.0 4 7.9 1.7 2.8 2 1 1 3 3 3 0 Vesicle transport v-SNARE protein N-terminus F-box-like_2 PF13013.6 AAS54248.2 - 0.16 12.0 0.0 0.54 10.2 0.0 1.8 2 0 0 2 2 2 0 F-box-like domain Pkinase PF00069.25 AAS54249.2 - 6.2e-72 242.1 0.0 7.8e-72 241.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54249.2 - 1.3e-35 122.9 0.0 2.3e-35 122.1 0.0 1.3 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 AAS54249.2 - 0.0017 17.8 0.0 0.0028 17.0 0.0 1.6 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 AAS54249.2 - 0.0035 17.3 0.0 0.032 14.2 0.1 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 AAS54249.2 - 0.012 14.6 0.1 0.054 12.4 0.0 2.2 2 1 0 2 2 2 0 Haspin like kinase domain AdoMet_MTase PF07757.13 AAS54250.1 - 1.8e-41 141.0 0.1 2.8e-41 140.4 0.1 1.3 1 0 0 1 1 1 1 Predicted AdoMet-dependent methyltransferase Methyltransf_31 PF13847.6 AAS54250.1 - 0.065 13.0 0.3 0.14 12.0 0.3 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 AAS54250.1 - 0.082 12.9 0.5 0.67 9.9 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_23 PF13489.6 AAS54250.1 - 0.084 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain SUV3_C PF12513.8 AAS54251.1 - 3.1e-15 55.8 3.6 8.4e-15 54.4 3.6 1.8 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal Helicase_C PF00271.31 AAS54251.1 - 4.6e-14 52.7 0.0 1.5e-13 51.1 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF866 PF05907.13 AAS54253.2 - 3.9e-41 140.5 1.7 5.8e-41 140.0 1.7 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF866) Cofilin_ADF PF00241.20 AAS54254.1 - 2.1e-17 63.0 0.0 4.4e-17 62.0 0.0 1.6 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein SH3_1 PF00018.28 AAS54254.1 - 3.1e-17 61.9 0.8 6.1e-17 61.0 0.8 1.5 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS54254.1 - 4.5e-16 58.4 0.8 1.2e-15 57.1 0.8 1.8 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS54254.1 - 1.5e-09 37.4 0.1 3.6e-09 36.2 0.0 1.7 2 0 0 2 2 2 1 Variant SH3 domain zf-LYAR PF08790.11 AAS54255.2 - 2.1e-13 49.9 7.5 3.7e-13 49.1 7.5 1.5 1 0 0 1 1 1 1 LYAR-type C2HC zinc finger COX6B PF02297.17 AAS54255.2 - 0.038 14.2 3.2 0.07 13.4 3.2 1.4 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIb zf-C2H2_4 PF13894.6 AAS54255.2 - 0.89 10.6 6.8 2.9 9.0 0.4 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Csm1_N PF18504.1 AAS54256.1 - 2.2e-26 92.0 7.8 2.2e-26 92.0 7.8 1.7 2 0 0 2 2 2 1 Csm1 N-terminal domain Csm1 PF12539.8 AAS54256.1 - 9e-23 80.7 0.0 1.3e-22 80.2 0.0 1.3 1 0 0 1 1 1 1 Chromosome segregation protein Csm1/Pcs1 CENP-Q PF13094.6 AAS54256.1 - 3.1e-05 24.2 2.5 4.9e-05 23.6 2.5 1.4 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit GAS PF13851.6 AAS54256.1 - 0.00093 18.6 7.3 0.0014 18.0 7.3 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding eIF3_subunit PF08597.10 AAS54256.1 - 0.0027 17.7 0.2 0.0028 17.6 0.2 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit DUF16 PF01519.16 AAS54256.1 - 0.0094 16.4 1.5 0.015 15.7 1.5 1.3 1 0 0 1 1 1 1 Protein of unknown function DUF16 TMF_DNA_bd PF12329.8 AAS54256.1 - 0.0095 15.9 4.7 0.016 15.2 4.7 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding Spc24 PF08286.11 AAS54256.1 - 0.011 15.9 0.1 0.017 15.3 0.1 1.5 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 bZIP_1 PF00170.21 AAS54256.1 - 0.011 15.8 5.5 1.1 9.4 0.7 2.4 2 0 0 2 2 2 0 bZIP transcription factor Lebercilin PF15619.6 AAS54256.1 - 0.014 15.1 4.0 0.014 15.1 4.0 1.4 2 0 0 2 2 1 0 Ciliary protein causing Leber congenital amaurosis disease Myosin_tail_1 PF01576.19 AAS54256.1 - 0.052 11.4 7.1 0.068 11.0 7.1 1.1 1 0 0 1 1 1 0 Myosin tail Phage_GP20 PF06810.11 AAS54256.1 - 0.066 13.0 3.7 0.12 12.2 3.7 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 SHE3 PF17078.5 AAS54256.1 - 0.076 12.7 1.5 0.12 12.1 1.5 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF4795 PF16043.5 AAS54256.1 - 0.085 12.4 2.0 0.15 11.7 1.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Herpes_ori_bp PF02399.15 AAS54256.1 - 0.1 10.6 0.1 0.13 10.2 0.1 1.0 1 0 0 1 1 1 0 Origin of replication binding protein Spc7 PF08317.11 AAS54256.1 - 0.12 11.3 4.6 0.17 10.7 4.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Complex1_49kDa PF00346.19 AAS54256.1 - 0.14 11.2 0.2 0.31 10.1 0.0 1.6 2 0 0 2 2 2 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit KASH_CCD PF14662.6 AAS54256.1 - 0.19 11.5 7.6 0.63 9.8 7.6 1.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH CENP-H PF05837.12 AAS54256.1 - 0.19 12.1 5.4 0.41 11.1 5.4 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 AAS54256.1 - 0.2 11.0 4.9 0.28 10.5 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 AAS54256.1 - 0.27 10.5 7.9 0.12 11.7 5.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 AAS54256.1 - 0.42 11.2 8.2 0.8 10.2 8.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Cnn_1N PF07989.11 AAS54256.1 - 0.5 10.5 4.5 0.32 11.2 2.0 1.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 TolA_bind_tri PF16331.5 AAS54256.1 - 0.67 10.1 9.1 0.22 11.6 6.0 1.8 2 0 0 2 2 1 0 TolA binding protein trimerisation CC2-LZ PF16516.5 AAS54256.1 - 1.1 9.7 9.4 0.75 10.2 4.7 2.3 2 1 1 3 3 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF4140 PF13600.6 AAS54256.1 - 4.8 7.7 12.5 48 4.5 12.5 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) WD40 PF00400.32 AAS54257.1 - 4.3e-50 166.6 14.8 2.5e-08 34.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat Tup_N PF08581.10 AAS54257.1 - 1.4e-29 102.2 13.7 2.1e-29 101.6 13.7 1.3 1 0 0 1 1 1 1 Tup N-terminal ANAPC4_WD40 PF12894.7 AAS54257.1 - 1e-14 54.6 0.0 9.9e-05 22.6 0.0 5.4 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 AAS54257.1 - 3e-08 32.8 0.5 0.15 10.7 0.0 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 AAS54257.1 - 9e-05 21.9 0.0 0.21 10.9 0.0 3.9 3 1 1 4 4 4 1 WD40-like domain Ge1_WD40 PF16529.5 AAS54257.1 - 0.0014 17.7 0.0 1 8.3 0.0 3.7 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 AAS54257.1 - 0.026 13.1 0.1 3.7 6.0 0.1 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain DUF2408 PF10303.9 AAS54257.1 - 0.39 11.3 2.9 0.68 10.5 2.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) DUF724 PF05266.14 AAS54257.1 - 2.1 8.2 5.7 3.3 7.5 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FapA PF03961.13 AAS54257.1 - 2.2 6.8 4.3 3 6.3 4.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Zn_clus PF00172.18 AAS54258.1 - 4.7e-08 33.0 8.6 7.2e-08 32.4 8.6 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain MDD_C PF18376.1 AAS54259.2 - 1e-65 221.0 0.0 1.3e-65 220.6 0.0 1.2 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 AAS54259.2 - 2.2e-10 40.6 1.9 6.9e-10 39.0 1.8 1.9 2 0 0 2 2 2 1 GHMP kinases N terminal domain UbiA PF01040.18 AAS54260.1 - 1.2e-45 155.8 20.8 1.7e-45 155.3 20.8 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3995 PF13160.6 AAS54261.2 - 0.26 11.6 4.5 1.1 9.6 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) Thioredoxin PF00085.20 AAS54262.1 - 1.1e-20 73.5 0.0 1.4e-20 73.2 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AAS54262.1 - 2.8e-05 24.5 0.0 6.2e-05 23.4 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 AAS54262.1 - 5.2e-05 23.0 0.0 6.4e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 AAS54262.1 - 8.4e-05 22.4 0.0 0.00019 21.3 0.0 1.6 1 1 1 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_8 PF13905.6 AAS54262.1 - 0.00079 19.7 0.0 0.5 10.7 0.0 2.1 1 1 1 2 2 2 2 Thioredoxin-like TraF PF13728.6 AAS54262.1 - 0.0015 18.4 0.0 0.0017 18.2 0.0 1.1 1 0 0 1 1 1 1 F plasmid transfer operon protein OST3_OST6 PF04756.13 AAS54262.1 - 0.017 14.5 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Redoxin PF08534.10 AAS54262.1 - 0.027 14.2 0.0 0.054 13.2 0.0 1.6 1 1 0 1 1 1 0 Redoxin Thioredoxin_7 PF13899.6 AAS54262.1 - 0.029 14.6 0.4 0.25 11.6 0.4 2.0 1 1 0 1 1 1 0 Thioredoxin-like TrbC_Ftype PF09673.10 AAS54262.1 - 0.036 14.1 0.0 0.041 13.9 0.0 1.3 1 1 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein DUF3322 PF11795.8 AAS54262.1 - 0.06 13.4 0.1 0.74 9.8 0.1 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) DDE_Tnp_1_2 PF13586.6 AAS54262.1 - 0.12 12.7 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Transposase DDE domain Thioredoxin_3 PF13192.6 AAS54262.1 - 0.13 12.3 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin domain DUF1932 PF09130.11 AAS54263.2 - 0.05 13.6 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) CH_2 PF06294.11 AAS54263.2 - 0.089 12.9 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 CH-like domain in sperm protein DUF1611 PF07755.11 AAS54263.2 - 0.15 11.3 0.1 0.2 10.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_C) P-loop domain Cation_efflux PF01545.21 AAS54264.2 - 4.1e-05 23.4 5.6 5.7e-05 22.9 3.8 2.1 1 1 1 2 2 2 1 Cation efflux family Med12 PF09497.10 AAS54265.2 - 4.6e-25 87.7 0.4 1.1e-24 86.5 0.4 1.7 1 0 0 1 1 1 1 Transcription mediator complex subunit Med12 DEAD PF00270.29 AAS54266.1 - 6.5e-39 133.5 0.2 1.1e-38 132.8 0.2 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS54266.1 - 7.8e-21 74.5 0.1 4.5e-20 72.0 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54266.1 - 4.2e-09 36.6 0.0 8.4e-09 35.7 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AAS54266.1 - 3.3e-07 29.3 0.1 5.5e-07 28.6 0.1 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF2075 PF09848.9 AAS54266.1 - 0.0017 17.6 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 AAS54266.1 - 0.0017 18.2 0.1 0.0039 17.1 0.0 1.6 2 0 0 2 2 2 1 Helicase Flavi_DEAD PF07652.14 AAS54266.1 - 0.0035 17.3 0.6 0.017 15.1 0.3 2.2 1 1 1 2 2 2 1 Flavivirus DEAD domain AAA_22 PF13401.6 AAS54266.1 - 0.011 16.0 0.3 0.041 14.2 0.2 2.1 2 1 0 2 2 2 0 AAA domain UvrD-helicase PF00580.21 AAS54266.1 - 0.03 13.8 0.0 0.055 13.0 0.0 1.5 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain CMS1 PF14617.6 AAS54266.1 - 0.06 12.7 0.2 0.12 11.7 0.2 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 AAS54266.1 - 0.074 13.4 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 AAA domain Ribosomal_S19 PF00203.21 AAS54267.1 - 7e-26 89.9 0.0 8.7e-26 89.6 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 PP2C PF00481.21 AAS54268.1 - 2.2e-30 106.2 0.0 1.2e-27 97.2 0.0 2.4 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 AAS54268.1 - 0.027 14.1 0.0 0.068 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein phosphatase 2C SpoIIE PF07228.12 AAS54268.1 - 0.14 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) Ribosom_S12_S23 PF00164.25 AAS54269.1 - 1.6e-34 117.9 1.1 2.1e-34 117.6 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 Ribosomal_S12 PF17487.2 AAS54269.1 - 0.12 13.2 0.0 0.32 11.8 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein S12 P34-Arc PF04045.14 AAS54270.1 - 2.2e-91 305.9 0.4 2.7e-91 305.6 0.4 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc PAT1 PF09770.9 AAS54271.1 - 1.8e-79 268.1 43.4 4.9e-67 226.9 22.6 5.2 3 2 0 3 3 3 3 Topoisomerase II-associated protein PAT1 TFIIA PF03153.13 AAS54271.1 - 0.0079 16.2 15.9 0.018 15.0 15.9 1.5 1 1 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Clathrin PF00637.20 AAS54273.1 - 0.006 16.5 0.8 0.32 10.9 0.0 3.8 3 1 1 4 4 4 1 Region in Clathrin and VPS NT5C PF06941.12 AAS54273.1 - 0.019 14.8 0.1 0.049 13.5 0.1 1.7 1 0 0 1 1 1 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) CBFD_NFYB_HMF PF00808.23 AAS54273.1 - 0.066 13.5 0.1 0.19 12.0 0.0 1.9 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone zf-C3HC4_4 PF15227.6 AAS54274.2 - 2e-09 37.4 10.6 2e-09 37.4 10.6 2.3 2 1 1 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 AAS54274.2 - 5.1e-09 35.9 9.6 5.1e-09 35.9 9.6 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 AAS54274.2 - 1.8e-07 30.9 6.2 1.8e-07 30.9 6.2 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS54274.2 - 6.7e-07 29.0 8.2 6.7e-07 29.0 8.2 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 AAS54274.2 - 9.2e-07 29.1 8.7 9.2e-07 29.1 8.7 2.3 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 AAS54274.2 - 1.4e-06 28.2 5.7 1.4e-06 28.2 5.7 1.9 2 0 0 2 2 1 1 RING-type zinc-finger zf-rbx1 PF12678.7 AAS54274.2 - 0.00029 21.1 4.9 0.00029 21.1 4.9 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AAS54274.2 - 0.00059 19.8 2.3 0.00059 19.8 2.3 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 AAS54274.2 - 0.0011 18.9 8.3 0.0011 18.9 8.3 2.5 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_6 PF14835.6 AAS54274.2 - 0.0013 18.5 7.7 0.029 14.2 2.0 2.4 2 0 0 2 2 2 2 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 AAS54274.2 - 0.0014 18.4 14.9 0.012 15.4 6.1 2.3 2 0 0 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 AAS54274.2 - 0.012 15.4 2.4 0.012 15.4 2.4 3.0 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain HypA PF01155.19 AAS54274.2 - 0.028 14.4 1.2 0.028 14.4 1.2 2.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA RecR PF02132.15 AAS54274.2 - 0.12 12.0 10.2 0.13 11.9 0.7 3.5 3 0 0 3 3 3 0 RecR protein DZR PF12773.7 AAS54274.2 - 0.23 11.5 11.6 0.4 10.7 0.9 2.6 2 1 0 2 2 2 0 Double zinc ribbon SPT6_acidic PF14632.6 AAS54274.2 - 0.49 11.0 0.0 0.49 11.0 0.0 3.0 3 2 0 3 3 2 0 Acidic N-terminal SPT6 PolC_DP2 PF03833.13 AAS54274.2 - 1.5 6.6 7.1 3.7 5.3 0.5 2.0 1 1 0 2 2 2 0 DNA polymerase II large subunit DP2 Baculo_IE-1 PF05290.11 AAS54274.2 - 2.4 8.1 9.2 0.2 11.6 3.9 1.9 2 1 1 3 3 2 0 Baculovirus immediate-early protein (IE-0) COX7a PF02238.15 AAS54275.2 - 6.3e-22 77.7 0.5 7.1e-22 77.6 0.5 1.0 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VII GFD1 PF17331.2 AAS54277.2 - 1.5e-08 34.6 0.4 1.5e-08 34.6 0.4 1.7 2 0 0 2 2 2 1 GFD1 mRNA transport factor Macoilin PF09726.9 AAS54277.2 - 2.8 6.4 4.9 3.7 6.0 4.9 1.2 1 0 0 1 1 1 0 Macoilin family SNF2_N PF00176.23 AAS54279.2 - 7.7e-58 195.9 0.1 1.3e-57 195.1 0.1 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 AAS54279.2 - 1.2e-15 57.8 0.0 3.7e-15 56.2 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54279.2 - 2e-13 50.7 0.0 2e-11 44.2 0.0 2.9 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS54279.2 - 1.5e-08 34.1 0.2 9.2e-08 31.6 0.3 2.2 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 DEAD PF00270.29 AAS54279.2 - 4e-05 23.5 0.1 0.00014 21.7 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AAS54279.2 - 0.006 15.8 0.0 0.01 15.1 0.0 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Glycos_transf_1 PF00534.20 AAS54279.2 - 0.077 12.5 0.1 0.16 11.5 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Sushi PF00084.20 AAS54279.2 - 0.092 13.4 0.0 37 5.0 0.0 2.9 2 0 0 2 2 2 0 Sushi repeat (SCR repeat) DUF2439 PF10382.9 AAS54279.2 - 0.13 12.6 0.0 0.38 11.1 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) bVLRF1 PF18826.1 AAS54280.1 - 2.8e-60 202.5 2.1 5.2e-60 201.6 0.5 2.1 2 0 0 2 2 2 1 bacteroidetes VLRF1 release factor Ank_5 PF13857.6 AAS54280.1 - 3e-05 24.2 0.1 8.4e-05 22.8 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) AKAP95 PF04988.12 AAS54280.1 - 0.0037 17.5 0.5 0.094 12.9 0.0 2.5 2 0 0 2 2 2 1 A-kinase anchoring protein 95 (AKAP95) zf-C2H2_jaz PF12171.8 AAS54280.1 - 0.034 14.4 0.8 0.09 13.1 0.8 1.8 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding PAS_7 PF12860.7 AAS54280.1 - 0.076 13.2 1.8 0.17 12.1 0.2 2.3 2 0 0 2 2 2 0 PAS fold Peptidase_M16 PF00675.20 AAS54280.1 - 0.13 12.2 2.3 1.5 8.8 0.2 2.9 3 0 0 3 3 3 0 Insulinase (Peptidase family M16) Ank_2 PF12796.7 AAS54280.1 - 0.14 12.7 0.0 0.31 11.6 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank PF00023.30 AAS54280.1 - 0.27 11.7 0.9 0.73 10.4 0.9 1.8 1 0 0 1 1 1 0 Ankyrin repeat URO-D PF01208.17 AAS54281.1 - 2.6e-129 431.3 0.0 2.9e-129 431.2 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) Peptidase_M28 PF04389.17 AAS54282.1 - 1.9e-36 125.7 0.1 3.3e-36 124.8 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 Peptidase_M20 PF01546.28 AAS54282.1 - 0.00071 19.3 0.0 0.002 17.8 0.0 1.4 1 1 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M42 PF05343.14 AAS54282.1 - 0.0082 15.2 0.0 0.019 14.0 0.0 1.5 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase Glyco_hydro81C PF17652.1 AAS54283.2 - 4.2e-147 490.0 5.8 5.7e-147 489.5 5.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 AAS54283.2 - 8.6e-88 294.6 0.3 3.2e-87 292.7 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolase family 81 N-terminal domain zf-C2H2 PF00096.26 AAS54284.1 - 2.3e-11 43.5 8.5 1.1e-05 25.5 0.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS54284.1 - 1.3e-08 34.9 3.0 6.9e-06 26.3 0.5 2.8 2 0 0 2 2 2 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS54284.1 - 1.8e-06 28.3 7.5 0.0048 17.6 0.2 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AAS54284.1 - 0.00067 19.6 2.5 0.0019 18.1 0.2 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AAS54284.1 - 0.011 16.1 0.1 0.065 13.5 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Zn_ribbon_SprT PF17283.2 AAS54284.1 - 0.017 15.0 0.9 0.017 15.0 0.9 1.7 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zf-C2H2_11 PF16622.5 AAS54284.1 - 0.068 12.9 0.4 0.068 12.9 0.4 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 AAS54284.1 - 0.07 13.4 1.0 0.26 11.6 1.0 1.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon Zn-ribbon_8 PF09723.10 AAS54284.1 - 0.25 11.5 1.9 3.6 7.8 1.3 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-met PF12874.7 AAS54284.1 - 0.4 11.1 3.4 2.8 8.5 0.1 2.5 2 0 0 2 2 2 0 Zinc-finger of C2H2 type ADK_lid PF05191.14 AAS54284.1 - 2.9 7.9 4.6 26 4.9 0.5 2.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid Fungal_trans_2 PF11951.8 AAS54285.2 - 3.1e-11 42.7 0.2 4.3e-10 39.0 0.0 2.1 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS54285.2 - 2.6e-05 24.2 8.4 5.8e-05 23.1 8.4 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Dfp1_Him1_M PF08630.10 AAS54286.1 - 7.9e-41 139.2 0.0 3.9e-40 137.0 0.0 2.2 2 0 0 2 2 2 1 Dfp1/Him1, central region zf-DBF PF07535.12 AAS54286.1 - 2.2e-19 69.3 1.0 3.9e-19 68.5 1.0 1.4 1 0 0 1 1 1 1 DBF zinc finger Ysc84 PF04366.12 AAS54286.1 - 0.16 11.7 0.0 0.34 10.7 0.0 1.5 1 0 0 1 1 1 0 Las17-binding protein actin regulator SLM4 PF16818.5 AAS54287.2 - 7.6e-61 204.8 0.1 9e-61 204.5 0.1 1.0 1 0 0 1 1 1 1 Protein SLM4 BCIP PF13862.6 AAS54287.2 - 0.21 11.4 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 p21-C-terminal region-binding protein UQ_con PF00179.26 AAS54288.1 - 3.1e-44 150.0 0.0 4.2e-44 149.6 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS54288.1 - 0.015 15.0 0.0 0.051 13.3 0.0 1.8 1 1 0 1 1 1 0 Prokaryotic E2 family B AMNp_N PF10423.9 AAS54288.1 - 0.063 12.9 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial AMP nucleoside phosphorylase N-terminus Nop14 PF04147.12 AAS54288.1 - 5.2 5.2 18.1 7 4.7 18.1 1.1 1 0 0 1 1 1 0 Nop14-like family Alg14 PF08660.11 AAS54289.1 - 7e-55 185.6 0.0 9.2e-55 185.3 0.0 1.1 1 0 0 1 1 1 1 Oligosaccharide biosynthesis protein Alg14 like TIM PF00121.18 AAS54290.2 - 3e-90 301.8 0.0 3.4e-90 301.7 0.0 1.0 1 0 0 1 1 1 1 Triosephosphate isomerase TetR_C_14 PF17754.1 AAS54290.2 - 0.016 15.2 0.5 0.032 14.2 0.5 1.4 1 0 0 1 1 1 0 MftR C-terminal domain 2-oxoacid_dh PF00198.23 AAS54291.1 - 1.9e-78 263.2 0.1 3e-78 262.5 0.1 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 AAS54291.1 - 7.6e-16 57.7 0.5 1.4e-15 56.8 0.5 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme HlyD_3 PF13437.6 AAS54291.1 - 6e-05 23.7 0.2 0.0036 18.0 0.1 2.6 1 1 1 2 2 2 1 HlyD family secretion protein GCV_H PF01597.19 AAS54291.1 - 0.00013 21.9 0.2 0.00026 20.9 0.2 1.5 1 0 0 1 1 1 1 Glycine cleavage H-protein Biotin_lipoyl_2 PF13533.6 AAS54291.1 - 0.00028 20.6 0.0 0.0025 17.6 0.0 2.3 1 1 1 2 2 2 1 Biotin-lipoyl like RnfC_N PF13375.6 AAS54291.1 - 0.0083 16.1 0.0 0.051 13.5 0.0 2.3 1 1 1 2 2 2 1 RnfC Barrel sandwich hybrid domain HlyD_D23 PF16576.5 AAS54291.1 - 0.037 13.3 0.9 0.09 12.0 0.0 2.0 2 1 1 3 3 3 0 Barrel-sandwich domain of CusB or HlyD membrane-fusion CCDC53 PF10152.9 AAS54291.1 - 0.81 10.1 3.9 1.3 9.4 3.9 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF3306 PF11748.8 AAS54291.1 - 1.9 9.4 8.2 4.2 8.3 8.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Choline_kinase PF01633.20 AAS54292.1 - 2.7e-62 210.1 0.0 3.6e-62 209.7 0.0 1.1 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kin_N PF04428.14 AAS54292.1 - 2e-11 43.4 0.0 5.8e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 Choline kinase N terminus APH PF01636.23 AAS54292.1 - 6.6e-10 39.3 0.0 0.00038 20.4 0.0 2.3 2 0 0 2 2 2 2 Phosphotransferase enzyme family HVSL PF09749.9 AAS54293.1 - 6.3e-08 32.4 0.0 7.8e-08 32.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein zf-C2H2 PF00096.26 AAS54294.1 - 5.7e-07 29.6 22.2 0.0039 17.5 0.8 3.9 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS54294.1 - 1e-05 26.0 13.1 0.11 13.4 1.8 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AAS54294.1 - 0.077 13.5 0.4 0.077 13.5 0.4 3.6 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_8 PF15909.5 AAS54294.1 - 0.15 12.3 3.2 0.54 10.6 3.2 1.9 1 1 0 1 1 1 0 C2H2-type zinc ribbon MMR1 PF08505.10 AAS54294.1 - 0.16 12.2 8.2 0.025 14.9 2.7 2.1 2 0 0 2 2 2 0 Mitochondrial Myo2 receptor-related protein AT_hook PF02178.19 AAS54294.1 - 0.6 10.2 4.8 2.6 8.2 4.8 2.2 1 0 0 1 1 1 0 AT hook motif DUF4834 PF16118.5 AAS54294.1 - 6.9 7.7 6.4 21 6.1 6.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF5421 PF17458.2 AAS54294.1 - 7 6.0 10.7 11 5.3 10.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5421) zf-C2H2_6 PF13912.6 AAS54294.1 - 7.1 6.7 13.8 3.6 7.7 0.1 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger WD40 PF00400.32 AAS54295.2 - 1.1e-44 149.5 29.7 7.5e-06 26.6 0.2 10.3 11 0 0 11 11 11 8 WD domain, G-beta repeat Utp12 PF04003.12 AAS54295.2 - 2.5e-19 69.5 0.5 5.1e-19 68.6 0.5 1.5 1 0 0 1 1 1 1 Dip2/Utp12 Family ANAPC4_WD40 PF12894.7 AAS54295.2 - 1.3e-15 57.5 11.4 9.1e-05 22.7 0.0 8.5 3 2 6 10 10 10 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 AAS54295.2 - 4.8e-10 39.3 2.1 0.00019 20.9 0.1 3.9 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 AAS54295.2 - 1.7e-06 27.0 10.8 0.17 10.5 0.0 6.5 5 2 0 6 6 6 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 AAS54295.2 - 8.5e-06 24.9 4.2 6.4 5.6 0.0 5.4 5 1 1 6 6 6 3 Partner and localizer of BRCA2 WD40 domain Ge1_WD40 PF16529.5 AAS54295.2 - 1.3e-05 24.3 7.1 0.5 9.3 0.0 6.7 3 2 2 6 6 6 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 AAS54295.2 - 3.1e-05 23.9 0.5 1.4 8.7 0.0 4.2 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 AAS54295.2 - 8.4e-05 21.1 0.6 0.22 9.8 0.0 3.5 2 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Hira PF07569.11 AAS54295.2 - 0.00012 21.9 2.7 0.2 11.4 0.1 4.3 3 1 0 3 3 3 1 TUP1-like enhancer of split Cytochrom_D1 PF02239.16 AAS54295.2 - 0.0029 16.2 0.0 3.1 6.3 0.0 3.2 4 0 0 4 4 4 2 Cytochrome D1 heme domain ELYS-bb PF16687.5 AAS54295.2 - 0.015 14.0 0.0 0.11 11.0 0.0 2.2 2 0 0 2 2 2 0 beta-propeller of ELYS nucleoporin TFIID_20kDa PF03847.13 AAS54296.1 - 2.7e-32 111.0 0.6 5.7e-32 110.0 0.6 1.6 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A FPP PF05911.11 AAS54296.1 - 0.00013 20.4 3.7 0.00018 19.8 3.7 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil TFIID-31kDa PF02291.15 AAS54296.1 - 0.0034 17.5 0.0 0.011 15.9 0.0 1.8 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 AAS54296.1 - 0.013 15.9 2.7 0.022 15.1 0.0 2.6 3 0 0 3 3 2 0 Core histone H2A/H2B/H3/H4 Seryl_tRNA_N PF02403.22 AAS54296.1 - 0.025 14.8 3.0 0.096 12.9 3.0 2.0 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 AAS54296.1 - 0.029 13.0 2.9 0.052 12.2 2.9 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A CBFD_NFYB_HMF PF00808.23 AAS54296.1 - 0.081 13.2 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone ATP-synt_E_2 PF08112.11 AAS54296.1 - 0.49 10.7 3.4 22 5.4 0.7 2.5 2 0 0 2 2 2 0 ATP synthase epsilon subunit ADIP PF11559.8 AAS54296.1 - 0.54 10.3 6.9 0.41 10.7 5.0 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 AAS54296.1 - 0.55 10.2 5.7 0.59 10.2 3.8 1.9 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 UPF0242 PF06785.11 AAS54296.1 - 0.94 9.6 7.2 1.9 8.5 7.2 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Prefoldin_2 PF01920.20 AAS54296.1 - 1 9.4 7.7 2 8.4 1.6 2.7 1 1 1 2 2 2 0 Prefoldin subunit Mod_r PF07200.13 AAS54296.1 - 1.8 8.7 9.4 1.3 9.2 6.9 1.9 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CLZ PF16526.5 AAS54296.1 - 1.9 8.9 4.6 2.2 8.7 1.8 2.4 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Syntaxin_2 PF14523.6 AAS54296.1 - 3.3 8.1 8.7 0.8 10.1 3.7 2.5 2 0 0 2 2 2 0 Syntaxin-like protein SPATA1_C PF15743.5 AAS54296.1 - 4.2 7.4 9.4 1.3 9.0 6.1 1.9 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus Cullin_binding PF03556.15 AAS54297.2 - 1.2e-28 100.0 0.6 1.8e-28 99.4 0.1 1.5 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 AAS54297.2 - 5.3e-10 39.0 0.1 1.4e-09 37.6 0.1 1.8 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 AAS54297.2 - 0.02 14.5 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 TAP C-terminal domain Cullin PF00888.22 AAS54298.1 - 2.3e-08 33.1 0.4 2.3e-08 33.1 0.4 1.9 2 1 0 2 2 2 1 Cullin family HTH_Tnp_ISL3 PF13542.6 AAS54298.1 - 0.068 12.6 0.0 0.2 11.1 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Asp PF00026.23 AAS54299.2 - 1.7e-69 234.7 0.0 2.1e-69 234.4 0.0 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AAS54299.2 - 1.2e-10 41.9 0.2 2.7e-10 40.8 0.2 1.7 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal gag-asp_proteas PF13975.6 AAS54299.2 - 0.0047 17.5 0.0 4.2 8.0 0.0 3.8 4 0 0 4 4 4 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 AAS54299.2 - 0.0073 16.9 0.1 6 7.6 0.0 3.4 3 0 0 3 3 3 1 Aspartyl protease Lar_N PF09861.9 AAS54299.2 - 0.18 10.9 0.0 0.3 10.2 0.0 1.2 1 0 0 1 1 1 0 Lactate racemase N-terminal domain zf-RING_2 PF13639.6 AAS54300.2 - 4.3e-10 39.7 8.7 7.3e-09 35.8 4.1 2.2 2 0 0 2 2 2 2 Ring finger domain zf-C3HC4_2 PF13923.6 AAS54300.2 - 4.8e-07 29.5 8.3 1.6e-06 27.8 4.1 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 AAS54300.2 - 2.1e-06 27.9 6.1 2.2e-06 27.8 3.3 2.1 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 AAS54300.2 - 3.4e-06 26.8 1.5 3.4e-06 26.8 1.5 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 AAS54300.2 - 9.4e-06 25.4 5.3 1.5e-05 24.8 2.1 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 AAS54300.2 - 3.5e-05 23.7 8.0 7.7e-05 22.6 1.6 2.7 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AAS54300.2 - 4.1e-05 23.4 4.3 0.00012 21.8 1.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 AAS54300.2 - 0.00012 22.2 1.6 0.00012 22.2 1.6 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 AAS54300.2 - 0.0072 16.3 5.0 0.0095 15.9 2.0 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 AAS54300.2 - 0.035 14.2 1.4 0.055 13.5 0.3 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 AAS54300.2 - 0.078 12.7 8.3 0.73 9.6 1.1 2.9 3 0 0 3 3 3 0 RING-like zinc finger zf-Nse PF11789.8 AAS54300.2 - 0.55 10.1 1.9 1 9.2 1.9 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_4 PF14570.6 AAS54300.2 - 0.8 9.5 4.3 1.1 9.1 1.7 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain WD40 PF00400.32 AAS54301.1 - 7.6e-13 48.7 14.6 0.006 17.4 0.0 6.4 6 0 0 6 6 6 4 WD domain, G-beta repeat Mod_r PF07200.13 AAS54302.1 - 3.6e-24 85.5 4.6 4.1e-24 85.3 4.6 1.0 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein ATG16 PF08614.11 AAS54302.1 - 0.0071 16.6 0.5 0.0071 16.6 0.5 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF4164 PF13747.6 AAS54302.1 - 0.012 15.9 6.4 0.26 11.6 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) DUF2043 PF09740.9 AAS54302.1 - 0.061 14.0 0.3 0.1 13.3 0.3 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2043) DUF4201 PF13870.6 AAS54302.1 - 0.1 12.3 7.1 2.9 7.6 2.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) ABC_tran_CTD PF16326.5 AAS54302.1 - 0.26 11.6 7.9 0.92 9.8 0.1 2.9 2 1 0 3 3 3 0 ABC transporter C-terminal domain FadA PF09403.10 AAS54302.1 - 0.52 10.8 5.2 0.83 10.2 1.5 2.2 2 1 0 2 2 2 0 Adhesion protein FadA DUF4140 PF13600.6 AAS54302.1 - 4.6 7.8 6.8 10 6.6 3.1 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Abhydrolase_2 PF02230.16 AAS54303.1 - 2.6e-45 154.9 0.0 3.2e-45 154.6 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 AAS54303.1 - 3.1e-07 30.3 0.0 5.9e-07 29.4 0.0 1.4 1 1 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 AAS54303.1 - 1.7e-06 27.8 0.0 6e-06 26.0 0.0 1.8 2 0 0 2 2 2 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 AAS54303.1 - 7.6e-06 25.4 0.0 0.0015 17.8 0.0 2.9 2 1 1 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AAS54303.1 - 7.6e-06 25.8 0.1 1.4 8.5 0.0 3.0 2 1 1 3 3 3 3 alpha/beta hydrolase fold Dopey_N PF04118.14 AAS54304.2 - 1e-111 373.0 4.2 1.2e-111 372.8 1.8 2.5 2 0 0 2 2 2 1 Dopey, N-terminal Pro_3_hydrox_C PF05373.11 AAS54304.2 - 0.08 13.0 0.0 0.46 10.6 0.0 2.3 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal MTS PF05175.14 AAS54305.1 - 5.9e-10 38.9 0.0 1.5e-09 37.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AAS54305.1 - 0.00011 22.8 0.0 0.00023 21.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AAS54305.1 - 0.0083 16.0 0.0 0.017 15.0 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS54305.1 - 0.01 16.6 0.0 0.017 15.9 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 AAS54305.1 - 0.012 16.2 0.1 0.029 15.0 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 AAS54305.1 - 0.016 15.0 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 AAS54305.1 - 0.023 14.1 0.0 0.034 13.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 AAS54305.1 - 0.054 13.4 0.0 0.08 12.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_33 PF10017.9 AAS54305.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.2 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent ubiquitin PF00240.23 AAS54306.2 - 5.6e-23 80.5 0.5 6.1e-23 80.4 0.5 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 AAS54306.2 - 4.9e-15 55.1 0.3 5.3e-15 55.0 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 AAS54306.2 - 9.7e-05 22.2 0.0 0.00011 22.0 0.0 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 AAS54306.2 - 0.002 18.6 0.1 0.0047 17.3 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-like domain TUG-UBL1 PF11470.8 AAS54306.2 - 0.04 14.1 0.0 0.044 14.0 0.0 1.2 1 0 0 1 1 1 0 TUG ubiquitin-like domain HAT PF02184.16 AAS54307.1 - 2.4e-19 69.0 34.1 2.6e-05 24.1 2.3 9.0 9 1 0 9 9 9 6 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 AAS54307.1 - 2.3e-18 65.3 29.4 9.2e-06 26.1 1.0 11.0 5 3 8 13 13 13 5 Tetratricopeptide repeat Suf PF05843.14 AAS54307.1 - 7.8e-15 55.6 10.0 4.9e-07 30.0 0.0 5.5 3 2 2 5 5 5 4 Suppressor of forked protein (Suf) TPR_19 PF14559.6 AAS54307.1 - 6.4e-10 39.4 6.0 2.6e-05 24.6 0.0 5.5 4 1 3 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 AAS54307.1 - 1.8e-06 27.9 0.1 0.26 11.8 0.0 4.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 AAS54307.1 - 6e-05 23.0 9.8 0.00012 22.0 2.3 4.3 4 0 0 4 4 4 1 Mad3/BUB1 homology region 1 TPR_16 PF13432.6 AAS54307.1 - 0.00023 21.8 10.3 0.0037 17.9 1.9 5.9 5 3 2 7 7 6 3 Tetratricopeptide repeat U3_assoc_6 PF08640.11 AAS54307.1 - 0.0023 17.9 0.3 0.0023 17.9 0.3 5.3 4 1 1 5 5 5 1 U3 small nucleolar RNA-associated protein 6 TPR_12 PF13424.6 AAS54307.1 - 0.064 13.5 8.3 9.6 6.6 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_2 PF07719.17 AAS54307.1 - 0.095 12.9 11.3 0.69 10.2 0.1 6.0 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 AAS54307.1 - 0.11 12.6 8.2 4.3 7.6 0.7 3.7 2 1 0 2 2 2 0 Tetratricopeptide repeat SF1-HH PF16275.5 AAS54308.2 - 6.7e-39 132.7 2.7 6.7e-39 132.7 2.7 1.7 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 AAS54308.2 - 3e-07 30.2 0.1 5.7e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 KH domain zf-CCHC PF00098.23 AAS54308.2 - 2.4e-05 24.2 8.5 0.0001 22.2 0.8 2.3 2 0 0 2 2 2 2 Zinc knuckle Lar_restr_allev PF14354.6 AAS54308.2 - 0.045 14.1 3.6 0.086 13.2 3.6 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-CCHC_3 PF13917.6 AAS54308.2 - 0.068 13.2 0.5 0.068 13.2 0.5 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 AAS54308.2 - 0.088 12.5 5.8 0.36 10.6 0.1 2.5 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zf-CCHC_2 PF13696.6 AAS54308.2 - 2.8 7.9 9.6 0.18 11.6 1.6 2.4 2 0 0 2 2 2 0 Zinc knuckle Lactamase_B_6 PF16661.5 AAS54309.2 - 1.1e-71 240.3 0.0 2.3e-71 239.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain CPSF100_C PF13299.6 AAS54309.2 - 9.5e-27 94.2 2.9 7.7e-24 84.8 0.1 3.3 2 1 1 3 3 3 2 Cleavage and polyadenylation factor 2 C-terminal DBC1 PF14443.6 AAS54309.2 - 0.033 14.2 0.1 0.075 13.0 0.1 1.5 1 0 0 1 1 1 0 DBC1 efThoc1 PF11957.8 AAS54310.1 - 2.2e-109 366.4 0.0 4.8e-109 365.2 0.0 1.5 1 1 1 2 2 2 1 THO complex subunit 1 transcription elongation factor Avl9 PF09794.9 AAS54311.1 - 6.2e-151 502.4 0.6 7.8e-151 502.1 0.6 1.1 1 0 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 AAS54311.1 - 1.6e-07 31.2 0.9 2.5e-06 27.3 0.9 2.7 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2347) SPA PF08616.10 AAS54311.1 - 6.6e-07 29.3 0.1 0.0054 16.7 0.0 2.6 2 0 0 2 2 2 2 Stabilization of polarity axis DENN PF02141.21 AAS54311.1 - 0.00088 19.3 0.8 0.2 11.6 0.3 2.6 2 1 1 3 3 3 2 DENN (AEX-3) domain Afi1 PF07792.12 AAS54311.1 - 0.011 16.2 0.6 0.039 14.4 0.0 2.0 2 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Rgp1 PF08737.10 AAS54312.1 - 4.2e-86 289.7 0.3 7e-86 289.0 0.3 1.3 1 0 0 1 1 1 1 Rgp1 U-box PF04564.15 AAS54312.1 - 0.098 12.8 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 U-box domain Arrestin_C PF02752.22 AAS54312.1 - 0.12 12.9 0.2 13 6.2 0.0 2.8 3 0 0 3 3 3 0 Arrestin (or S-antigen), C-terminal domain RT_RNaseH_2 PF17919.1 AAS54313.1 - 3.1e-25 88.1 0.0 5.9e-25 87.2 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 AAS54313.1 - 3.7e-23 81.8 0.0 8.7e-23 80.6 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 AAS54313.1 - 2.6e-15 56.6 0.0 5.6e-15 55.5 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Retrotrans_gag PF03732.17 AAS54313.1 - 3.7e-08 33.5 0.0 9.5e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Retrotransposon gag protein DUF4939 PF16297.5 AAS54313.1 - 8.4e-05 22.4 0.0 0.00021 21.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4939) Pro_isomerase PF00160.21 AAS54314.1 - 4.8e-48 163.4 0.0 5.3e-48 163.3 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Thioredoxin_3 PF13192.6 AAS54314.1 - 0.051 13.6 0.1 0.43 10.7 0.0 2.1 1 1 1 2 2 2 0 Thioredoxin domain RNA_polI_A14 PF08203.11 AAS54315.1 - 4e-22 78.7 0.0 1.8e-21 76.6 0.0 1.9 2 0 0 2 2 2 1 Yeast RNA polymerase I subunit RPA14 Semialdhyde_dhC PF02774.18 AAS54316.1 - 2.7e-43 148.2 0.0 4.1e-43 147.6 0.0 1.3 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 AAS54316.1 - 2.3e-30 105.5 0.0 4.2e-30 104.7 0.0 1.4 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Sacchrp_dh_NADP PF03435.18 AAS54316.1 - 0.0072 16.6 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DXP_reductoisom PF02670.16 AAS54316.1 - 0.027 15.2 0.0 0.096 13.4 0.0 2.0 2 0 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase NAD_binding_10 PF13460.6 AAS54316.1 - 0.03 14.2 0.0 0.058 13.3 0.0 1.6 1 0 0 1 1 1 0 NAD(P)H-binding Methyltransf_16 PF10294.9 AAS54317.1 - 9.8e-05 22.1 0.0 0.21 11.3 0.0 2.2 1 1 0 2 2 2 2 Lysine methyltransferase DDOST_48kD PF03345.14 AAS54317.1 - 0.15 10.9 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta SAC3_GANP PF03399.16 AAS54318.1 - 2.9e-99 332.2 1.8 4.4e-99 331.6 1.8 1.3 1 0 0 1 1 1 1 SAC3/GANP family SAC3 PF12209.8 AAS54318.1 - 5.6e-19 68.1 2.7 1.4e-18 66.8 2.7 1.7 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain CSN8_PSD8_EIF3K PF10075.9 AAS54318.1 - 0.067 13.2 0.0 0.19 11.7 0.0 1.7 1 0 0 1 1 1 0 CSN8/PSMD8/EIF3K family Na_H_Exchanger PF00999.21 AAS54319.2 - 6.8e-89 298.3 25.4 8.1e-89 298.1 25.4 1.1 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Nha1_C PF08619.10 AAS54319.2 - 6e-60 203.8 29.1 5.8e-54 184.0 12.8 2.0 1 1 0 2 2 2 2 Alkali metal cation/H+ antiporter Nha1 C terminus AA_permease PF00324.21 AAS54320.2 - 3.4e-71 240.3 45.3 2.2e-70 237.6 45.3 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54320.2 - 2.9e-27 95.6 43.9 6.1e-27 94.5 43.7 1.6 1 1 0 1 1 1 1 Amino acid permease TPR_2 PF07719.17 AAS54321.1 - 2.9e-09 36.3 3.7 0.011 15.8 0.5 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54321.1 - 5.3e-08 32.5 0.6 0.24 11.7 0.2 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS54321.1 - 7.8e-06 25.6 0.2 2.2 8.5 0.0 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 AAS54321.1 - 7.1e-05 22.4 6.9 0.038 13.7 0.1 4.6 5 1 1 6 6 6 2 TPR repeat TPR_14 PF13428.6 AAS54321.1 - 7.5e-05 23.2 8.5 0.0097 16.7 0.1 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS54321.1 - 7.8e-05 22.3 6.4 0.57 10.1 0.6 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS54321.1 - 0.00096 19.6 9.2 4.1 8.0 0.1 5.2 3 3 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54321.1 - 0.0011 19.1 1.5 10 6.5 0.0 3.7 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54321.1 - 0.1 13.3 4.0 14 6.4 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat TipAS PF07739.13 AAS54321.1 - 0.26 11.8 2.8 15 6.1 0.4 3.6 2 2 2 4 4 4 0 TipAS antibiotic-recognition domain SH3_9 PF14604.6 AAS54322.2 - 5.2e-11 42.2 0.1 1.2e-10 41.0 0.1 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 AAS54322.2 - 1.5e-10 40.5 0.0 3.1e-10 39.5 0.0 1.6 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 AAS54322.2 - 3.9e-06 26.5 0.0 8.9e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Variant SH3 domain Cwf_Cwc_15 PF04889.12 AAS54323.1 - 8.3e-15 55.2 16.3 8.5e-06 25.7 0.7 3.0 2 1 1 3 3 3 3 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 AAS54323.1 - 0.18 10.0 3.1 0.18 10.0 3.1 1.0 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 AAS54323.1 - 7.5 4.5 10.3 9 4.3 10.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi SLS PF14611.6 AAS54324.2 - 1.5e-40 139.4 0.3 2.6e-40 138.6 0.3 1.4 1 0 0 1 1 1 1 Mitochondrial inner-membrane-bound regulator Fructosamin_kin PF03881.14 AAS54325.2 - 0.15 11.3 0.0 0.3 10.2 0.0 1.4 1 0 0 1 1 1 0 Fructosamine kinase Pro_dh PF01619.18 AAS54326.1 - 6.5e-59 199.9 0.0 8.3e-59 199.5 0.0 1.1 1 0 0 1 1 1 1 Proline dehydrogenase Diphthami_syn_2 PF01902.17 AAS54327.1 - 1.5e-35 122.7 0.0 4.7e-35 121.1 0.0 1.8 1 1 0 1 1 1 1 Diphthamide synthase Ribonuc_L-PSP PF01042.21 AAS54327.1 - 9.1e-14 51.5 0.0 4.6e-09 36.3 0.0 2.6 3 0 0 3 3 3 2 Endoribonuclease L-PSP Sec1 PF00995.23 AAS54329.1 - 4.1e-88 297.1 1.2 4.7e-88 296.9 1.2 1.0 1 0 0 1 1 1 1 Sec1 family Glyco_hydro81C PF17652.1 AAS54330.1 - 1.4e-154 514.5 6.8 2.1e-154 514.0 6.8 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 C-terminal domain Glyco_hydro_81 PF03639.13 AAS54330.1 - 7.1e-93 311.3 0.4 1e-92 310.8 0.4 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 81 N-terminal domain DUF4477 PF14780.6 AAS54331.1 - 4.8e-05 23.1 2.1 0.084 12.5 0.1 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4477) UPF0060 PF02694.15 AAS54331.1 - 0.029 14.6 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised BCR, YnfA/UPF0060 family CPSF_A PF03178.15 AAS54332.1 - 0.002 17.5 0.0 0.26 10.6 0.0 3.0 3 1 1 4 4 4 1 CPSF A subunit region MOFRL PF05161.13 AAS54332.1 - 0.0097 16.1 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 1 MOFRL family WD40 PF00400.32 AAS54332.1 - 0.022 15.6 1.1 56 4.8 0.0 3.9 4 0 0 4 4 4 0 WD domain, G-beta repeat Sec5 PF15469.6 AAS54333.1 - 7.9e-56 188.9 5.9 7.9e-56 188.9 5.9 2.3 2 0 0 2 2 2 1 Exocyst complex component Sec5 FRB_dom PF08771.11 AAS54333.1 - 0.026 14.9 0.3 0.026 14.9 0.3 3.8 4 0 0 4 4 4 0 FKBP12-rapamycin binding domain Antimicrobial15 PF08110.12 AAS54333.1 - 1.9 8.9 3.1 2.8 8.4 0.2 2.5 2 0 0 2 2 2 0 Ocellatin family Orthopox_A49R PF06489.11 AAS54333.1 - 2.3 8.4 10.2 6.3 7.0 0.3 4.0 3 1 1 4 4 4 0 Orthopoxvirus A49R protein LSM PF01423.22 AAS54334.1 - 4e-17 61.6 0.1 4.8e-17 61.4 0.1 1.1 1 0 0 1 1 1 1 LSM domain Tail_tube PF10618.9 AAS54334.1 - 0.0016 18.3 0.1 0.029 14.3 0.0 2.0 1 1 1 2 2 2 1 Phage tail tube protein SM-ATX PF14438.6 AAS54334.1 - 0.026 14.6 0.1 0.039 14.1 0.1 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Pep3_Vps18 PF05131.14 AAS54335.1 - 1.9e-36 125.1 0.0 5.3e-36 123.7 0.0 1.7 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family Clathrin PF00637.20 AAS54335.1 - 1.2e-06 28.4 1.6 1.2e-06 28.4 1.6 3.3 3 1 0 3 3 3 1 Region in Clathrin and VPS zf-RING_UBOX PF13445.6 AAS54335.1 - 0.00046 20.2 1.0 0.0011 19.0 1.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger Vps39_2 PF10367.9 AAS54335.1 - 0.0012 19.3 3.6 0.0015 18.9 0.3 2.8 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 2 zf-C3HC4_2 PF13923.6 AAS54335.1 - 0.0014 18.4 1.4 0.0045 16.8 1.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 AAS54335.1 - 0.0029 17.5 1.5 0.011 15.6 1.5 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AAS54335.1 - 0.0054 16.5 2.3 0.019 14.7 2.3 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 AAS54335.1 - 0.019 15.3 1.3 0.019 15.3 1.3 2.2 2 0 0 2 2 2 0 Ring finger domain zf-RING_5 PF14634.6 AAS54335.1 - 0.021 14.8 8.5 0.075 13.0 8.5 2.1 1 1 0 1 1 1 0 zinc-RING finger domain zf-rbx1 PF12678.7 AAS54335.1 - 0.1 12.9 0.6 0.29 11.5 0.6 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3H2C3 PF17122.5 AAS54335.1 - 1.2 9.2 5.4 0.25 11.4 1.2 2.1 2 0 0 2 2 2 0 Zinc-finger TFIID_30kDa PF03540.13 AAS54336.1 - 1.3e-26 92.3 0.1 3.2e-26 91.0 0.1 1.6 2 0 0 2 2 2 1 Transcription initiation factor TFIID 23-30kDa subunit Bromo_TP PF07524.13 AAS54336.1 - 0.097 12.7 0.2 0.4 10.7 0.0 1.9 2 0 0 2 2 2 0 Bromodomain associated CDC37_N PF03234.14 AAS54337.1 - 3.6e-45 154.0 5.8 3.6e-45 154.0 5.8 3.3 3 1 0 3 3 3 1 Cdc37 N terminal kinase binding CDC37_M PF08565.11 AAS54337.1 - 1.5e-42 144.3 3.7 1.5e-42 144.3 3.7 2.0 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain CDC37_C PF08564.10 AAS54337.1 - 4.6e-32 110.1 6.4 4.6e-32 110.1 6.4 2.4 2 1 0 2 2 2 1 Cdc37 C terminal domain BST2 PF16716.5 AAS54337.1 - 0.17 12.5 0.1 0.17 12.5 0.1 3.2 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 FliD_N PF02465.18 AAS54337.1 - 8.5 7.1 7.0 3.6 8.3 0.1 3.3 3 1 1 4 4 4 0 Flagellar hook-associated protein 2 N-terminus DUF2415 PF10313.9 AAS54338.1 - 2.2e-20 72.3 2.0 5.7e-20 71.0 2.0 1.7 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) WASH-7_N PF14745.6 AAS54338.1 - 0.093 11.2 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 WASH complex subunit 7, N-terminal Stb3 PF10330.9 AAS54339.1 - 1.3e-31 108.4 0.1 2.6e-31 107.5 0.1 1.4 1 0 0 1 1 1 1 Putative Sin3 binding protein DUF5435 PF17503.2 AAS54339.1 - 0.24 11.1 0.7 0.5 10.1 0.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5435) Stm1_N PF09598.10 AAS54340.1 - 1.1e-08 35.8 4.8 1.1e-08 35.8 4.8 4.2 2 1 1 3 3 3 1 Stm1 HABP4_PAI-RBP1 PF04774.15 AAS54340.1 - 0.0062 17.4 10.6 0.0062 17.4 10.6 3.0 3 1 0 3 3 3 1 Hyaluronan / mRNA binding family NUDIX PF00293.28 AAS54341.1 - 5.7e-10 39.3 0.0 1.2e-09 38.4 0.0 1.5 1 1 0 1 1 1 1 NUDIX domain Mem_trans PF03547.18 AAS54342.1 - 7.2e-27 93.8 0.0 1.8e-26 92.5 0.0 1.7 1 1 0 1 1 1 1 Membrane transport protein Cyd_oper_YbgE PF09600.10 AAS54342.1 - 0.0014 18.9 4.4 0.0018 18.6 0.6 2.8 2 0 0 2 2 2 1 Cyd operon protein YbgE (Cyd_oper_YbgE) AMP-binding PF00501.28 AAS54343.1 - 1.9e-86 290.3 0.4 4.7e-86 289.0 0.0 1.7 2 0 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 AAS54343.1 - 5.7e-25 88.1 0.2 1.4e-24 86.9 0.2 1.7 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AAS54343.1 - 7.4e-20 70.6 0.2 1.9e-19 69.3 0.2 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Sec7 PF01369.20 AAS54344.2 - 7.6e-67 224.5 0.3 3.4e-66 222.4 0.1 2.3 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 AAS54344.2 - 4.5e-43 146.9 1.5 4.5e-43 146.9 1.5 3.8 4 0 0 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF1981 PF09324.10 AAS54344.2 - 5.1e-28 96.8 0.8 5.1e-28 96.8 0.8 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) DCB PF16213.5 AAS54344.2 - 2.4e-14 53.4 10.1 5.2e-13 49.0 0.5 4.1 4 0 0 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 GTP_CH_N PF12471.8 AAS54345.1 - 9.2e-77 257.2 0.0 1.3e-76 256.7 0.0 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 AAS54345.1 - 2.9e-17 62.7 0.0 4.5e-17 62.1 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II DUF2382 PF09557.10 AAS54345.1 - 0.14 12.4 0.4 0.26 11.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2382) GTP_EFTU PF00009.27 AAS54346.2 - 4.3e-45 153.6 0.0 7.7e-45 152.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AAS54346.2 - 2.6e-34 117.9 0.6 6.8e-34 116.5 0.6 1.8 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AAS54346.2 - 2.5e-08 34.2 0.6 7.1e-08 32.7 0.6 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS54346.2 - 0.002 18.2 0.1 0.011 15.8 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase TFIIA PF03153.13 AAS54346.2 - 0.2 11.6 21.6 0.29 11.1 21.6 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit IPK PF03770.16 AAS54347.2 - 4.4e-56 189.9 0.0 5.5e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Inositol polyphosphate kinase Zip PF02535.22 AAS54348.2 - 9.7e-69 232.1 10.0 1.2e-68 231.8 10.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter ABC2_membrane PF01061.24 AAS54349.2 - 1e-78 263.6 59.5 2.3e-45 154.6 21.8 3.1 4 0 0 4 4 4 2 ABC-2 type transporter ABC_tran PF00005.27 AAS54349.2 - 2.6e-33 115.4 0.0 5.9e-17 62.5 0.0 3.3 3 0 0 3 3 3 2 ABC transporter PDR_CDR PF06422.12 AAS54349.2 - 1.9e-29 101.4 6.7 2.6e-27 94.5 0.4 3.4 2 0 0 2 2 2 2 CDR ABC transporter ABC_trans_N PF14510.6 AAS54349.2 - 9.1e-16 58.3 0.0 2.4e-15 56.9 0.0 1.7 1 0 0 1 1 1 1 ABC-transporter N-terminal AAA_16 PF13191.6 AAS54349.2 - 3e-07 31.0 0.4 0.00061 20.2 0.0 3.4 3 0 0 3 3 3 1 AAA ATPase domain RsgA_GTPase PF03193.16 AAS54349.2 - 7.9e-06 25.9 0.0 0.002 18.0 0.0 3.1 3 0 0 3 3 3 1 RsgA GTPase AAA_25 PF13481.6 AAS54349.2 - 3.9e-05 23.3 0.1 0.00025 20.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain AAA_18 PF13238.6 AAS54349.2 - 0.00015 22.3 0.1 0.0027 18.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AAS54349.2 - 0.00035 20.3 0.1 0.045 13.5 0.1 3.2 3 0 0 3 3 3 1 P-loop containing region of AAA domain AAA_23 PF13476.6 AAS54349.2 - 0.0038 17.8 0.1 0.74 10.3 0.1 2.5 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 AAS54349.2 - 0.0041 16.6 0.0 0.1 12.0 0.0 2.7 3 0 0 3 3 3 1 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 AAS54349.2 - 0.013 15.3 1.6 2.3 7.9 0.2 3.3 4 0 0 4 4 4 0 AAA domain AAA_22 PF13401.6 AAS54349.2 - 0.015 15.6 0.7 1.3 9.3 0.1 3.0 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AAS54349.2 - 0.018 15.3 1.6 4.2 7.6 0.0 3.2 4 0 0 4 4 4 0 AAA domain AAA_33 PF13671.6 AAS54349.2 - 0.025 14.8 0.2 0.18 12.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AAS54349.2 - 0.034 14.2 0.1 1.8 8.7 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase cobW PF02492.19 AAS54349.2 - 0.036 13.6 1.7 0.13 11.9 0.1 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_21 PF13304.6 AAS54349.2 - 0.079 12.8 0.2 16 5.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 AAS54349.2 - 1.5 8.7 3.2 5.4 6.9 0.1 2.8 3 0 0 3 3 2 0 NACHT domain CbtA PF09490.10 AAS54349.2 - 1.6 8.5 7.2 3 7.5 0.4 3.1 3 0 0 3 3 3 0 Probable cobalt transporter subunit (CbtA) HMG_box PF00505.19 AAS54350.1 - 3.1e-12 46.7 3.4 3.1e-12 46.7 3.4 2.3 2 1 0 2 2 2 1 HMG (high mobility group) box HMG_box_2 PF09011.10 AAS54350.1 - 3.5e-08 33.9 2.8 3.5e-08 33.9 2.8 2.1 2 0 0 2 2 2 1 HMG-box domain Transketolase_N PF00456.21 AAS54350.1 - 0.057 12.4 0.7 0.088 11.7 0.7 1.2 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain MRP-S28 PF10213.9 AAS54351.1 - 9.6e-53 177.9 0.7 1.9e-52 177.0 0.7 1.5 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit protein Ada3 PF10198.9 AAS54352.1 - 1.3e-44 151.5 3.0 3.3e-44 150.2 3.0 1.7 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 17kDa_Anti_2 PF16998.5 AAS54352.1 - 9.5 6.2 7.8 0.44 10.5 0.4 2.3 2 0 0 2 2 2 0 17 kDa outer membrane surface antigen Peptidase_M16 PF00675.20 AAS54353.1 - 2e-50 170.6 0.0 3.8e-50 169.7 0.0 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_C PF05193.21 AAS54353.1 - 1.1e-32 113.6 0.0 6.2e-32 111.1 0.0 1.9 2 0 0 2 2 2 1 Peptidase M16 inactive domain CybS PF05328.12 AAS54354.1 - 2.3e-52 176.2 0.0 2.9e-52 175.9 0.0 1.1 1 0 0 1 1 1 1 CybS, succinate dehydrogenase cytochrome B small subunit PXA PF02194.15 AAS54356.1 - 1e-08 35.4 0.6 3.6e-08 33.6 0.3 2.0 1 1 1 2 2 2 1 PXA domain PseudoU_synth_2 PF00849.22 AAS54357.1 - 9.6e-18 64.8 0.0 8.6e-17 61.7 0.0 2.0 1 1 0 1 1 1 1 RNA pseudouridylate synthase Nipped-B_C PF12830.7 AAS54358.1 - 6.6e-35 120.8 3.5 6.6e-35 120.8 3.5 3.5 4 0 0 4 4 4 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 AAS54358.1 - 2.5e-16 59.7 0.2 4.7e-15 55.6 0.1 3.3 2 0 0 2 2 2 1 HEAT repeat associated with sister chromatid cohesion HEAT PF02985.22 AAS54358.1 - 0.065 13.5 1.0 30 5.2 0.0 4.7 6 0 0 6 6 6 0 HEAT repeat Soyouz_module PF14313.6 AAS54358.1 - 0.25 11.2 0.4 13 5.7 0.0 2.8 3 0 0 3 3 3 0 N-terminal region of Paramyxovirinae phosphoprotein (P) SAS4 PF15460.6 AAS54359.2 - 1.1e-26 92.9 3.7 3.6e-26 91.1 3.7 1.9 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 Metallophos PF00149.28 AAS54360.2 - 4.5e-13 50.2 0.8 6.8e-13 49.6 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AAS54360.2 - 0.096 12.9 0.0 0.16 12.2 0.0 1.4 1 1 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain Sec10 PF07393.11 AAS54361.2 - 1.4e-205 684.9 24.6 1.7e-205 684.6 24.6 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF3654 PF12376.8 AAS54361.2 - 0.0054 16.9 0.1 0.11 12.7 0.1 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3654) RB_B PF01857.20 AAS54361.2 - 0.057 13.4 0.4 0.43 10.6 0.1 2.7 3 0 0 3 3 3 0 Retinoblastoma-associated protein B domain AvrRpt-cleavage PF05627.11 AAS54361.2 - 0.064 12.6 0.1 0.15 11.5 0.1 1.5 1 0 0 1 1 1 0 Cleavage site for pathogenic type III effector avirulence factor Avr Occludin_ELL PF07303.13 AAS54361.2 - 0.13 13.0 0.7 2.3 9.0 0.1 3.4 2 1 0 2 2 2 0 Occludin homology domain SKA2 PF16740.5 AAS54361.2 - 0.29 10.9 3.4 0.23 11.2 0.7 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Phosducin PF02114.16 AAS54362.1 - 1.6e-09 37.1 0.0 1.9e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Phosducin Thioredoxin PF00085.20 AAS54362.1 - 3.7e-06 26.9 0.0 6.1e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Lipase_C PF18067.1 AAS54362.1 - 0.07 13.7 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 Lipase C-terminal domain FliT PF05400.13 AAS54362.1 - 0.18 12.7 4.4 0.82 10.5 2.7 2.4 1 1 1 2 2 2 0 Flagellar protein FliT ubiquitin PF00240.23 AAS54363.1 - 6.2e-35 118.8 0.4 3e-34 116.6 0.5 2.0 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 AAS54363.1 - 2e-21 75.9 0.9 2e-21 75.9 0.9 1.8 2 0 0 2 2 2 1 Ribosomal protein S27a Rad60-SLD PF11976.8 AAS54363.1 - 7.1e-16 57.8 0.6 7.1e-16 57.8 0.6 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 AAS54363.1 - 3.1e-05 24.3 0.1 0.00013 22.4 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 AAS54363.1 - 0.001 19.2 0.6 0.0027 17.8 0.6 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 AAS54363.1 - 0.0041 17.5 0.6 0.012 16.0 0.0 1.8 1 1 2 3 3 3 1 Ubiquitin-like domain IBR PF01485.21 AAS54363.1 - 0.0049 17.1 0.2 0.0091 16.2 0.2 1.4 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain TBK1_ULD PF18396.1 AAS54363.1 - 0.0065 16.4 0.0 0.0099 15.8 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 AAS54363.1 - 0.015 15.8 0.5 0.022 15.3 0.5 1.2 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 AAS54363.1 - 0.019 15.0 1.1 5.4 7.1 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like domain Big_1 PF02369.16 AAS54364.2 - 0.09 12.8 0.3 9.2 6.4 0.1 2.6 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) PRELI PF04707.14 AAS54365.1 - 4.4e-52 176.0 0.3 6.5e-52 175.5 0.3 1.2 1 0 0 1 1 1 1 PRELI-like family DHHC PF01529.20 AAS54366.1 - 2.5e-32 111.8 14.8 2.5e-32 111.8 14.8 2.6 2 2 0 2 2 2 1 DHHC palmitoyltransferase AzlD PF05437.12 AAS54366.1 - 1 9.6 6.9 0.093 12.9 1.4 1.9 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) dCMP_cyt_deam_1 PF00383.23 AAS54368.1 - 1.8e-15 56.6 0.5 2.3e-15 56.3 0.5 1.1 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam_2 PF08211.12 AAS54368.1 - 4e-10 40.0 3.6 1.1e-08 35.4 0.7 2.1 2 0 0 2 2 2 2 Cytidine and deoxycytidylate deaminase zinc-binding region LmjF365940-deam PF14421.6 AAS54368.1 - 0.0075 15.9 1.4 1 8.9 0.2 2.1 1 1 0 2 2 2 2 A distinct subfamily of CDD/CDA-like deaminases Peptidase_M24 PF00557.24 AAS54369.1 - 7.8e-51 172.7 0.0 9.5e-51 172.5 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 zf-C6H2 PF15801.5 AAS54369.1 - 6.3e-15 55.2 9.6 1.5e-14 54.0 9.6 1.7 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding RGM_N PF06535.12 AAS54369.1 - 0.0063 16.7 0.1 0.012 15.8 0.1 1.4 1 0 0 1 1 1 1 Repulsive guidance molecule (RGM) N-terminus Cpn60_TCP1 PF00118.24 AAS54370.1 - 1.2e-157 525.5 3.0 1.3e-157 525.4 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Sec1 PF00995.23 AAS54371.1 - 8.9e-120 401.6 3.8 1e-119 401.4 3.8 1.0 1 0 0 1 1 1 1 Sec1 family RAC_head PF16717.5 AAS54371.1 - 0.05 14.6 0.2 1.8 9.6 0.4 2.7 2 0 0 2 2 2 0 Ribosome-associated complex head domain TIP49 PF06068.13 AAS54372.1 - 1.7e-166 553.7 0.6 2.2e-166 553.4 0.6 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain TIP49_C PF17856.1 AAS54372.1 - 1.1e-21 76.7 0.6 3.4e-21 75.1 0.2 2.1 2 0 0 2 2 2 1 TIP49 AAA-lid domain AAA PF00004.29 AAS54372.1 - 9.3e-09 35.8 0.8 3.7e-05 24.2 0.0 3.1 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AAS54372.1 - 1.4e-06 28.2 1.3 0.00014 21.7 0.0 3.0 3 0 0 3 3 3 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AAS54372.1 - 0.00074 19.8 0.0 0.0018 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AAS54372.1 - 0.0018 18.6 0.7 2.2 8.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain DnaB_C PF03796.15 AAS54372.1 - 0.0028 17.0 0.0 0.006 16.0 0.0 1.5 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_16 PF13191.6 AAS54372.1 - 0.015 15.7 0.8 0.096 13.1 0.1 2.6 2 1 0 2 2 2 0 AAA ATPase domain CPT PF07931.12 AAS54372.1 - 0.028 14.3 0.0 0.064 13.1 0.0 1.7 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 AAS54372.1 - 0.04 13.2 0.1 0.13 11.5 0.1 1.8 2 0 0 2 2 2 0 Zeta toxin Mg_chelatase PF01078.21 AAS54372.1 - 0.087 12.2 0.2 5.4 6.3 0.0 2.4 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 AAS54372.1 - 0.13 11.4 0.1 0.82 8.7 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_5 PF07728.14 AAS54372.1 - 0.17 11.9 0.3 2.9 7.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SIR2 PF02146.17 AAS54373.1 - 2.7e-31 108.9 0.0 4e-31 108.3 0.0 1.3 1 0 0 1 1 1 1 Sir2 family DUF3039 PF11238.8 AAS54373.1 - 0.34 10.7 5.1 2.2 8.1 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3039) zinc-ribbons_6 PF07191.12 AAS54373.1 - 2.9 7.9 7.1 0.51 10.4 2.4 2.1 2 0 0 2 2 2 0 zinc-ribbons ATP_bind_1 PF03029.17 AAS54374.1 - 2e-87 293.0 0.0 2.3e-87 292.8 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein CLP1_P PF16575.5 AAS54374.1 - 0.00046 20.0 0.0 0.0037 17.1 0.0 2.3 2 1 2 4 4 4 1 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_10 PF12846.7 AAS54374.1 - 0.002 17.1 0.0 0.0031 16.5 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain MeaB PF03308.16 AAS54374.1 - 0.0031 16.5 0.0 0.0079 15.2 0.0 1.6 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 AAS54374.1 - 0.0032 17.4 0.3 0.48 10.3 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 AAS54374.1 - 0.0079 15.8 0.0 1.6 8.3 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain KAP_NTPase PF07693.14 AAS54374.1 - 0.014 14.7 0.0 0.027 13.7 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain CbiA PF01656.23 AAS54374.1 - 0.022 14.8 0.0 0.028 14.5 0.0 1.4 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain MMR_HSR1 PF01926.23 AAS54374.1 - 0.027 14.6 0.0 0.088 12.9 0.0 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 AAS54374.1 - 0.033 13.9 0.0 0.074 12.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AAS54374.1 - 0.034 13.9 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AAS54374.1 - 0.037 13.8 0.0 0.089 12.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 AAS54374.1 - 0.04 14.3 0.0 0.14 12.6 0.0 1.9 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 AAS54374.1 - 0.076 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_19 PF13245.6 AAS54374.1 - 0.077 13.3 0.0 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 AAS54374.1 - 0.08 13.5 0.1 0.17 12.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS54374.1 - 0.084 13.4 0.0 0.17 12.4 0.0 1.6 1 0 0 1 1 1 0 ABC transporter T2SSE PF00437.20 AAS54374.1 - 0.087 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein DnaJ PF00226.31 AAS54374.1 - 0.12 12.5 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 DnaJ domain AAA_16 PF13191.6 AAS54374.1 - 0.18 12.2 1.1 0.59 10.5 0.1 2.2 2 1 1 3 3 3 0 AAA ATPase domain NACHT PF05729.12 AAS54374.1 - 0.18 11.7 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 AAS54374.1 - 0.19 11.2 0.0 0.5 9.9 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region cobW PF02492.19 AAS54374.1 - 0.19 11.3 0.0 6.1 6.4 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain zf_CCCH_4 PF18345.1 AAS54375.2 - 1.7e-06 27.9 8.1 3.5e-06 26.9 8.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 AAS54375.2 - 8.6e-06 25.5 4.4 1.7e-05 24.6 4.4 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 AAS54375.2 - 4.1e-05 23.3 2.8 8.1e-05 22.3 2.8 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 AAS54375.2 - 0.013 16.2 1.5 0.033 14.9 1.5 1.5 1 0 0 1 1 1 0 Torus domain zf-CCCH_3 PF15663.5 AAS54375.2 - 0.14 12.4 2.9 0.14 12.3 0.9 1.9 2 0 0 2 2 2 0 Zinc-finger containing family zf-CCCH_2 PF14608.6 AAS54375.2 - 0.72 10.4 5.8 1.3 9.6 5.8 1.4 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Arv1 PF04161.13 AAS54376.1 - 4e-63 213.4 2.5 5.7e-63 212.9 2.5 1.2 1 0 0 1 1 1 1 Arv1-like family RSN1_7TM PF02714.15 AAS54377.1 - 1.1e-84 284.0 24.0 1.1e-84 284.0 24.0 1.7 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate RSN1_TM PF13967.6 AAS54377.1 - 4.4e-37 127.3 0.9 4.4e-37 127.3 0.9 2.6 2 1 1 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 AAS54377.1 - 5.9e-32 111.3 0.0 1.2e-31 110.4 0.0 1.5 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter PI3Ka PF00613.20 AAS54378.1 - 7.2e-65 217.9 1.2 7.2e-65 217.9 1.2 1.5 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 AAS54378.1 - 1.9e-48 165.5 0.0 1.1e-31 110.5 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 AAS54378.1 - 3.4e-26 91.8 0.0 1e-25 90.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 DEAD PF00270.29 AAS54379.1 - 1.1e-39 136.0 0.1 2.2e-39 135.0 0.1 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS54379.1 - 5.6e-26 91.1 0.0 2.1e-24 86.0 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54379.1 - 5.1e-06 26.6 0.0 1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Terminase_1 PF03354.15 AAS54379.1 - 0.0091 14.6 0.0 0.015 13.8 0.0 1.2 1 0 0 1 1 1 1 Phage Terminase LD_cluster3 PF18180.1 AAS54379.1 - 0.018 14.7 0.0 2.1 7.9 0.0 2.5 2 0 0 2 2 2 0 SLOG cluster3 family 6PF2K PF01591.18 AAS54379.1 - 0.028 13.7 0.5 0.059 12.7 0.5 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase SWI2_SNF2 PF18766.1 AAS54379.1 - 0.03 14.0 0.0 0.06 13.0 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase P4Ha_N PF08336.11 AAS54380.1 - 0.0094 16.0 1.5 0.018 15.1 1.5 1.4 1 0 0 1 1 1 1 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF4200 PF13863.6 AAS54380.1 - 0.011 16.1 4.8 0.029 14.8 4.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Retrotrans_gag PF03732.17 AAS54380.1 - 0.02 15.2 0.7 5.3 7.4 0.0 2.8 2 1 0 2 2 2 0 Retrotransposon gag protein 14-3-3 PF00244.20 AAS54380.1 - 0.022 14.3 1.2 0.042 13.3 1.2 1.4 1 0 0 1 1 1 0 14-3-3 protein GAS PF13851.6 AAS54380.1 - 0.06 12.7 5.0 0.12 11.7 5.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 AAS54380.1 - 0.12 11.2 4.4 0.21 10.4 4.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein PhaC_N PF07167.13 AAS54380.1 - 0.16 11.6 2.0 0.19 11.3 0.7 1.7 2 0 0 2 2 2 0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus zf-C4H2 PF10146.9 AAS54380.1 - 5.7 7.2 8.6 13 6.0 8.6 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein CoaE PF01121.20 AAS54381.1 - 5.3e-60 202.1 0.1 8.5e-60 201.5 0.1 1.3 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 AAS54381.1 - 7.8e-06 26.5 1.0 0.00016 22.2 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AAS54381.1 - 6.5e-05 23.1 2.7 0.00015 21.9 0.2 2.7 2 1 0 2 2 2 1 AAA domain PRK PF00485.18 AAS54381.1 - 0.0004 20.2 0.1 0.0064 16.3 0.0 2.5 3 0 0 3 3 3 1 Phosphoribulokinase / Uridine kinase family AAA_17 PF13207.6 AAS54381.1 - 0.0013 19.1 0.9 0.0061 17.0 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA_28 PF13521.6 AAS54381.1 - 0.0015 18.8 1.6 0.0015 18.8 0.0 1.9 3 0 0 3 3 3 1 AAA domain SKI PF01202.22 AAS54381.1 - 0.0026 17.9 0.5 0.0096 16.1 0.0 2.2 3 1 0 3 3 3 1 Shikimate kinase Cytidylate_kin2 PF13189.6 AAS54381.1 - 0.046 13.8 0.0 0.046 13.8 0.0 2.6 3 1 0 3 3 3 0 Cytidylate kinase-like family Ribonuc_P_40 PF08584.11 AAS54381.1 - 0.049 12.9 0.0 0.077 12.3 0.0 1.3 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit TraL PF07178.11 AAS54381.1 - 0.1 13.1 0.0 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 TraL protein tRNA_lig_kinase PF08303.11 AAS54381.1 - 0.12 12.4 0.0 0.21 11.7 0.0 1.4 1 0 0 1 1 1 0 tRNA ligase kinase domain ApbA_C PF08546.11 AAS54382.1 - 5.1e-19 68.7 0.0 7.7e-19 68.1 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal SET PF00856.28 AAS54383.1 - 0.14 12.5 0.0 0.5 10.7 0.0 1.7 1 1 0 1 1 1 0 SET domain BPL_LplA_LipB PF03099.19 AAS54384.1 - 1e-17 64.2 0.0 1.7e-17 63.5 0.0 1.3 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family FHA PF00498.26 AAS54385.3 - 2e-18 66.5 2.4 9.2e-18 64.4 0.2 2.9 3 0 0 3 3 3 1 FHA domain Yop-YscD_cpl PF16697.5 AAS54385.3 - 4.3e-06 27.0 0.0 1.6e-05 25.1 0.0 2.0 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF2407_C PF13373.6 AAS54385.3 - 0.1 12.8 2.3 0.09 12.9 0.6 1.8 2 1 0 2 2 2 0 DUF2407 C-terminal domain DUF4407 PF14362.6 AAS54385.3 - 0.16 11.3 7.1 0.27 10.6 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ISG65-75 PF11727.8 AAS54385.3 - 0.21 10.8 9.1 0.32 10.2 9.1 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF4164 PF13747.6 AAS54385.3 - 0.38 11.1 8.8 0.9 9.9 8.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) ALMT PF11744.8 AAS54385.3 - 0.94 8.2 6.1 1.4 7.7 6.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.15 AAS54385.3 - 1.6 8.2 9.5 2.6 7.5 9.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit EMC3_TMCO1 PF01956.16 AAS54385.3 - 5.8 6.6 5.7 16 5.2 4.1 2.3 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF3896 PF13035.6 AAS54385.3 - 6.7 7.0 10.7 4 7.7 7.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3896) DASH_Spc19 PF08287.11 AAS54386.1 - 1.5e-33 115.9 12.4 2.8e-33 115.0 12.4 1.4 1 1 0 1 1 1 1 Spc19 DUF4515 PF14988.6 AAS54386.1 - 0.0014 18.5 0.7 0.0014 18.5 0.7 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4515) CLZ PF16526.5 AAS54386.1 - 0.0087 16.4 11.4 0.03 14.7 3.1 2.7 3 1 0 3 3 3 2 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Hid1 PF12722.7 AAS54386.1 - 0.014 13.5 0.5 0.017 13.3 0.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Not3 PF04065.15 AAS54386.1 - 0.03 13.7 0.8 0.05 13.0 0.7 1.4 1 1 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component DUF4407 PF14362.6 AAS54386.1 - 0.031 13.6 0.7 0.032 13.6 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PLAC9 PF15205.6 AAS54386.1 - 0.49 10.8 1.8 1 9.8 0.2 2.1 2 0 0 2 2 2 0 Placenta-specific protein 9 DUF4140 PF13600.6 AAS54386.1 - 1 9.9 5.4 6 7.4 0.8 2.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Rogdi_lz PF10259.9 AAS54387.1 - 1.5e-59 201.7 1.1 1.7e-59 201.5 1.1 1.0 1 0 0 1 1 1 1 Rogdi leucine zipper containing protein Coq4 PF05019.13 AAS54388.1 - 2.7e-91 304.8 0.0 3.4e-91 304.5 0.0 1.1 1 0 0 1 1 1 1 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Cation_efflux PF01545.21 AAS54389.1 - 7.3e-40 136.8 18.0 7.3e-40 136.8 18.0 2.5 2 1 0 2 2 2 1 Cation efflux family Topoisom_bac PF01131.20 AAS54390.1 - 3.1e-108 362.4 0.0 3.7e-108 362.2 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 AAS54390.1 - 1.7e-17 63.5 0.0 3.9e-17 62.3 0.0 1.7 1 0 0 1 1 1 1 Toprim domain EST1_DNA_bind PF10373.9 AAS54391.1 - 4.5e-64 216.6 0.3 7.8e-64 215.9 0.3 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain EST1 PF10374.9 AAS54391.1 - 2.7e-22 79.9 0.4 9.8e-22 78.1 0.0 2.2 2 1 0 2 2 2 1 Telomerase activating protein Est1 Zn_clus PF00172.18 AAS54392.1 - 5.9e-11 42.3 7.1 9.8e-11 41.6 7.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Aminotran_5 PF00266.19 AAS54393.2 - 1.9e-13 50.1 0.0 2.7e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V E1-E2_ATPase PF00122.20 AAS54394.2 - 1.6e-32 112.5 26.0 1.7e-29 102.6 0.1 4.0 3 1 1 4 4 4 2 E1-E2 ATPase Cation_ATPase_C PF00689.21 AAS54394.2 - 8.3e-29 100.6 5.4 8.3e-29 100.6 5.4 2.7 3 0 0 3 3 3 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 AAS54394.2 - 6.9e-19 69.0 0.0 3.5e-14 53.6 0.0 2.8 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS54394.2 - 7.8e-19 67.6 0.0 1.5e-18 66.6 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Cation_ATPase_N PF00690.26 AAS54394.2 - 3.4e-16 58.7 0.0 7.6e-16 57.6 0.0 1.6 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AAS54394.2 - 0.0017 18.1 1.4 0.0054 16.5 0.8 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase RuvC_III PF18541.1 AAS54394.2 - 0.045 13.7 0.1 0.086 12.8 0.1 1.4 1 0 0 1 1 1 0 RuvC endonuclease subdomain 3 PAXIP1_C PF15364.6 AAS54394.2 - 0.16 12.3 0.1 0.3 11.4 0.1 1.3 1 0 0 1 1 1 0 PAXIP1-associated-protein-1 C term PTIP binding protein PIP5K PF01504.18 AAS54395.1 - 2.3e-97 325.5 1.4 4.3e-97 324.6 1.4 1.4 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase W2 PF02020.18 AAS54396.1 - 9.1e-14 51.4 0.6 6e-13 48.7 0.2 2.6 2 0 0 2 2 2 1 eIF4-gamma/eIF5/eIF2-epsilon Hexapep PF00132.24 AAS54396.1 - 9.6e-12 44.1 14.7 6.7e-05 22.4 1.5 4.0 1 1 3 4 4 4 4 Bacterial transferase hexapeptide (six repeats) NTP_transferase PF00483.23 AAS54396.1 - 2.7e-11 43.5 0.0 6.1e-11 42.4 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyl transferase DUF4954 PF16314.5 AAS54396.1 - 0.002 16.3 5.3 0.0075 14.4 5.3 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4954) NTP_transf_3 PF12804.7 AAS54396.1 - 0.004 17.5 0.1 0.013 15.9 0.0 1.9 2 0 0 2 2 2 1 MobA-like NTP transferase domain Fucokinase PF07959.12 AAS54396.1 - 0.016 14.1 1.6 0.031 13.2 1.6 1.5 1 0 0 1 1 1 0 L-fucokinase Hexapep_2 PF14602.6 AAS54396.1 - 0.091 12.5 18.6 0.98 9.2 4.3 3.5 1 1 3 4 4 4 0 Hexapeptide repeat of succinyl-transferase Ras PF00071.22 AAS54397.1 - 2.6e-51 173.5 0.0 3e-51 173.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS54397.1 - 1.6e-18 67.0 0.0 2.3e-18 66.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS54397.1 - 1.7e-07 30.8 0.0 2.3e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Cpn60_TCP1 PF00118.24 AAS54398.2 - 9.2e-151 502.8 12.4 1e-150 502.6 12.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Fungal_trans_2 PF11951.8 AAS54399.1 - 2e-09 36.8 0.7 2e-09 36.8 0.7 1.8 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS54399.1 - 1.4e-08 34.7 13.1 2.5e-08 33.9 13.1 1.4 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain Macoilin PF09726.9 AAS54399.1 - 0.9 8.0 12.3 1.9 7.0 12.3 1.4 1 0 0 1 1 1 0 Macoilin family Aha1_N PF09229.11 AAS54400.1 - 5.5e-37 127.0 0.0 1.2e-36 125.9 0.0 1.6 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal AHSA1 PF08327.11 AAS54400.1 - 4.5e-14 52.8 0.2 8e-14 51.9 0.2 1.4 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AAS54400.1 - 6.8e-05 23.2 0.2 0.00016 22.0 0.2 1.6 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Proteasome PF00227.26 AAS54401.1 - 6.8e-47 159.4 0.0 1e-46 158.8 0.0 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AAS54401.1 - 1.9e-15 56.2 0.1 3.7e-15 55.3 0.1 1.5 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature SAP30_Sin3_bdg PF13867.6 AAS54401.1 - 0.027 14.8 0.0 0.058 13.7 0.0 1.5 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Rsc14 PF08586.10 AAS54402.1 - 1.5e-37 128.4 0.2 2e-37 128.0 0.2 1.2 1 0 0 1 1 1 1 RSC complex, Rsc14/Ldb7 subunit ERG4_ERG24 PF01222.17 AAS54403.1 - 7.9e-166 552.1 16.0 8.9e-166 551.9 16.0 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family PUF PF00806.19 AAS54404.2 - 3.4e-64 209.1 5.5 1.8e-09 36.8 0.4 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Toxin_17 PF08086.11 AAS54404.2 - 1.6 9.1 5.5 1.5 9.2 3.8 1.9 1 1 0 1 1 1 0 Ergtoxin family E1-E2_ATPase PF00122.20 AAS54405.1 - 1.2e-47 161.8 6.7 4.9e-47 159.8 5.9 2.4 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AAS54405.1 - 8.7e-19 68.6 0.3 2.2e-18 67.3 0.3 1.7 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_N PF00690.26 AAS54405.1 - 7.2e-11 41.6 0.4 4.9e-10 39.0 0.0 2.3 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 AAS54405.1 - 0.0016 18.3 0.7 0.0043 16.8 0.1 1.9 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 AAS54405.1 - 0.0085 16.2 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Cation transport ATPase (P-type) DUF2613 PF11021.8 AAS54405.1 - 1.5 9.0 6.3 27 5.0 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) Zn_clus PF00172.18 AAS54407.1 - 3.3e-07 30.3 12.9 7.5e-07 29.2 12.9 1.7 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UDPGP PF01704.18 AAS54408.1 - 1.9e-185 616.4 0.0 7.7e-185 614.4 0.0 1.7 2 0 0 2 2 2 1 UTP--glucose-1-phosphate uridylyltransferase DUF4301 PF14134.6 AAS54408.1 - 0.019 13.8 0.1 0.11 11.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4301) HAD_2 PF13419.6 AAS54409.1 - 3.2e-18 66.5 0.0 4.1e-18 66.1 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AAS54409.1 - 1.2e-09 38.7 0.0 2.9e-09 37.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AAS54409.1 - 9.4e-05 22.5 0.0 0.00021 21.3 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Pribosyl_synth PF14572.6 AAS54410.1 - 9e-40 136.7 2.6 3.3e-35 121.8 2.1 2.2 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 AAS54410.1 - 6.6e-39 132.4 0.2 2.3e-38 130.7 0.0 1.9 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 AAS54410.1 - 4.8e-15 55.4 0.5 1.5e-14 53.9 0.5 1.7 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AAS54410.1 - 0.0012 18.4 0.1 0.0022 17.5 0.1 1.4 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase BRAP2 PF07576.12 AAS54411.1 - 6.4e-28 96.9 0.0 1.3e-27 95.9 0.0 1.4 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 AAS54411.1 - 1.1e-21 77.0 8.2 3e-21 75.5 8.2 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 AAS54411.1 - 1.3e-08 35.0 9.7 1.3e-08 35.0 9.7 2.6 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 AAS54411.1 - 2.6e-06 27.2 10.0 2.6e-06 27.2 10.0 2.5 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS54411.1 - 1.8e-05 24.6 8.0 1.8e-05 24.6 8.0 2.6 2 1 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 AAS54411.1 - 2.5e-05 23.9 4.2 2.5e-05 23.9 4.2 2.4 2 0 0 2 2 2 1 RING-like zinc finger zf-rbx1 PF12678.7 AAS54411.1 - 2.8e-05 24.3 7.0 2.8e-05 24.3 7.0 2.1 2 0 0 2 2 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 AAS54411.1 - 0.00012 22.0 5.9 0.00012 22.0 5.9 2.8 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 AAS54411.1 - 0.00019 21.2 20.2 0.00088 19.1 6.2 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 AAS54411.1 - 0.00035 20.6 4.1 0.00035 20.6 4.1 2.2 2 0 0 2 2 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 AAS54411.1 - 0.00041 20.2 8.4 0.00041 20.2 8.4 2.3 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) Filament PF00038.21 AAS54411.1 - 0.0028 17.3 4.2 0.0045 16.6 4.2 1.2 1 0 0 1 1 1 1 Intermediate filament protein Macoilin PF09726.9 AAS54411.1 - 0.0038 15.9 1.5 0.0046 15.6 1.5 1.1 1 0 0 1 1 1 1 Macoilin family zf-RING_4 PF14570.6 AAS54411.1 - 0.0039 16.9 8.4 0.011 15.6 8.4 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain Rootletin PF15035.6 AAS54411.1 - 0.012 15.7 5.8 0.022 14.8 5.8 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FlaC_arch PF05377.11 AAS54411.1 - 0.036 14.5 0.1 0.085 13.3 0.1 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) PspA_IM30 PF04012.12 AAS54411.1 - 0.05 13.2 7.6 0.14 11.8 7.6 1.5 1 1 0 1 1 1 0 PspA/IM30 family DUF2205 PF10224.9 AAS54411.1 - 0.093 12.7 2.5 0.21 11.6 2.5 1.6 1 0 0 1 1 1 0 Short coiled-coil protein Prok-RING_4 PF14447.6 AAS54411.1 - 0.1 12.5 22.5 1.6 8.7 11.9 3.5 1 1 1 3 3 3 0 Prokaryotic RING finger family 4 XkdW PF09636.10 AAS54411.1 - 0.17 12.0 1.4 0.42 10.7 1.4 1.6 1 0 0 1 1 1 0 XkdW protein Zwint PF15556.6 AAS54411.1 - 0.25 10.8 7.3 0.42 10.1 7.3 1.3 1 0 0 1 1 1 0 ZW10 interactor CLZ PF16526.5 AAS54411.1 - 0.51 10.7 5.4 0.3 11.5 0.8 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 AAS54411.1 - 0.65 10.7 5.0 0.39 11.4 1.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA CENP-F_leu_zip PF10473.9 AAS54411.1 - 0.9 9.6 12.7 0.48 10.5 9.6 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FANCI_S3 PF14677.6 AAS54412.1 - 0.00073 19.3 0.3 0.0032 17.2 0.0 2.3 3 0 0 3 3 3 1 FANCI solenoid 3 Form_Nir_trans PF01226.17 AAS54413.2 - 3e-58 197.0 27.4 4e-58 196.6 27.4 1.1 1 0 0 1 1 1 1 Formate/nitrite transporter HEAT PF02985.22 AAS54414.1 - 0.026 14.7 0.6 14 6.3 0.0 4.6 4 1 0 4 4 4 0 HEAT repeat Cnd1 PF12717.7 AAS54414.1 - 0.027 14.5 4.7 0.81 9.7 0.2 3.9 3 1 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Exonuc_VII_S PF02609.16 AAS54414.1 - 0.07 13.2 2.8 0.24 11.5 0.1 2.5 2 0 0 2 2 2 0 Exonuclease VII small subunit Ric8 PF10165.9 AAS54414.1 - 0.11 11.5 6.6 0.11 11.5 0.4 2.9 2 1 0 2 2 2 0 Guanine nucleotide exchange factor synembryn RPAP1_C PF08620.10 AAS54414.1 - 0.13 12.4 0.0 0.53 10.4 0.0 2.0 2 0 0 2 2 2 0 RPAP1-like, C-terminal PHD PF00628.29 AAS54415.1 - 1.9e-15 56.5 21.2 5.6e-10 39.0 8.8 3.1 2 1 1 3 3 3 2 PHD-finger PHD_2 PF13831.6 AAS54415.1 - 0.00093 18.7 10.9 0.15 11.7 0.3 3.7 3 0 0 3 3 3 2 PHD-finger zf-HC5HC2H PF13771.6 AAS54415.1 - 0.01 16.0 8.1 0.041 14.1 2.0 2.7 2 0 0 2 2 2 0 PHD-like zinc-binding domain AAA_lid_6 PF17866.1 AAS54415.1 - 0.012 15.8 0.3 0.04 14.1 0.3 1.9 1 0 0 1 1 1 0 AAA lid domain zf-PHD-like PF15446.6 AAS54415.1 - 0.2 11.3 5.9 3.8 7.1 0.7 2.9 2 0 0 2 2 2 0 PHD/FYVE-zinc-finger like domain dsDNA_bind PF01984.20 AAS54416.2 - 5.5e-19 68.5 7.8 3.5e-17 62.7 7.8 2.0 1 1 0 1 1 1 1 Double-stranded DNA-binding domain EF-1_beta_acid PF10587.9 AAS54416.2 - 0.098 13.1 0.6 0.098 13.1 0.6 2.6 4 0 0 4 4 4 0 Eukaryotic elongation factor 1 beta central acidic region Cu_amine_oxid PF01179.20 AAS54417.2 - 7.8e-139 463.1 0.0 9.2e-139 462.9 0.0 1.0 1 0 0 1 1 1 1 Copper amine oxidase, enzyme domain Cu_amine_oxidN2 PF02727.16 AAS54417.2 - 0.0057 16.9 0.0 0.013 15.7 0.0 1.6 1 0 0 1 1 1 1 Copper amine oxidase, N2 domain Cg6151-P PF10233.9 AAS54418.1 - 4e-35 120.5 10.3 5e-35 120.2 10.3 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein CG6151-P zf-C2H2 PF00096.26 AAS54419.1 - 8.1e-05 22.9 19.3 0.00031 21.0 6.1 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 AAS54419.1 - 0.0012 19.1 5.8 0.0021 18.3 5.8 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 AAS54419.1 - 0.0013 19.4 19.5 0.031 15.1 6.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger GAGA PF09237.11 AAS54419.1 - 0.13 12.0 2.1 0.32 10.8 1.5 1.9 1 1 1 2 2 2 0 GAGA factor zf-H2C2_2 PF13465.6 AAS54419.1 - 0.17 12.4 19.1 0.27 11.7 1.5 3.3 3 0 0 3 3 3 0 Zinc-finger double domain PyrI_C PF02748.15 AAS54419.1 - 0.25 11.3 1.5 0.96 9.4 0.2 2.1 2 0 0 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 AAS54419.1 - 0.43 10.9 9.0 3.1 8.2 2.0 2.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF2024 PF09630.10 AAS54419.1 - 1.3 8.9 3.4 0.48 10.3 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2024) zf-H2C2_5 PF13909.6 AAS54419.1 - 3.9 7.3 21.7 1 9.2 6.8 2.7 2 1 0 2 2 2 0 C2H2-type zinc-finger domain NIF PF03031.18 AAS54420.1 - 3.1e-50 170.0 0.0 4e-50 169.6 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2608 PF11019.8 AAS54420.1 - 0.052 13.0 0.1 0.21 11.1 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2608) MFS_1 PF07690.16 AAS54421.1 - 8.6e-40 136.7 19.1 1.2e-39 136.3 17.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS54421.1 - 6.1e-12 45.1 9.6 6.1e-12 45.1 9.6 3.3 2 1 1 3 3 3 1 Sugar (and other) transporter Malic_M PF03949.15 AAS54422.2 - 1.9e-83 279.7 0.0 2.5e-83 279.3 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 AAS54422.2 - 1.1e-60 204.6 0.0 1.6e-60 204.0 0.0 1.3 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain TFIIE_alpha PF02002.17 AAS54423.2 - 1.4e-30 105.3 0.6 3.7e-30 103.9 0.1 2.0 2 0 0 2 2 2 1 TFIIE alpha subunit TF_Zn_Ribbon PF08271.12 AAS54423.2 - 2.2e-08 33.4 0.1 5.5e-08 32.2 0.1 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding GntR PF00392.21 AAS54423.2 - 0.063 12.9 0.0 0.21 11.3 0.0 1.9 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family zf-CHY PF05495.12 AAS54423.2 - 0.095 13.2 0.2 0.22 12.0 0.2 1.5 1 0 0 1 1 1 0 CHY zinc finger ThiF PF00899.21 AAS54424.2 - 7.8e-44 149.9 0.0 1.2e-43 149.2 0.0 1.2 1 0 0 1 1 1 1 ThiF family TrkA_N PF02254.18 AAS54424.2 - 0.0015 18.8 0.1 0.0055 17.0 0.0 2.0 2 0 0 2 2 2 1 TrkA-N domain Sacchrp_dh_NADP PF03435.18 AAS54424.2 - 0.0051 17.1 0.0 0.13 12.5 0.1 2.3 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AAS54424.2 - 0.0089 16.1 0.0 0.017 15.2 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase UDPG_MGDP_dh_N PF03721.14 AAS54424.2 - 0.1 12.2 0.1 0.2 11.2 0.1 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_7 PF13241.6 AAS54424.2 - 0.16 12.4 0.0 0.51 10.8 0.0 1.9 1 0 0 1 1 1 0 Putative NAD(P)-binding Mito_carr PF00153.27 AAS54425.1 - 5.5e-60 199.3 0.6 3.8e-20 71.6 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 AAS54426.1 - 2.2e-56 187.8 1.8 5.8e-21 74.2 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AAS54426.1 - 0.32 10.1 0.9 8.3 5.5 0.0 2.8 3 0 0 3 3 3 0 Gammaproteobacterial serine protease DUF2370 PF10176.9 AAS54427.2 - 1.7e-79 266.6 0.0 2.1e-79 266.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) SNF5 PF04855.12 AAS54428.2 - 6.4e-51 173.4 2.6 6.4e-51 173.4 2.6 6.4 2 2 1 4 4 4 1 SNF5 / SMARCB1 / INI1 Trypan_PARP PF05887.11 AAS54428.2 - 5.7 6.9 10.0 12 5.9 8.6 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Adap_comp_sub PF00928.21 AAS54429.2 - 2.8e-37 128.5 0.0 3.5e-37 128.2 0.0 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 AAS54429.2 - 0.026 14.5 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Clathrin adaptor complex small chain DUF3663 PF12404.8 AAS54429.2 - 0.1 12.6 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Peptidase adh_short PF00106.25 AAS54430.1 - 1.9e-88 295.0 11.6 1.5e-44 151.8 3.7 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AAS54430.1 - 2.5e-70 236.7 11.2 1.5e-37 129.4 1.9 2.7 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AAS54430.1 - 2.2e-31 109.1 7.2 1.3e-15 57.8 0.3 2.4 2 0 0 2 2 2 2 KR domain MaoC_dehydratas PF01575.19 AAS54430.1 - 5.9e-28 96.9 0.0 1.3e-27 95.8 0.0 1.5 1 0 0 1 1 1 1 MaoC like domain DUF1776 PF08643.10 AAS54430.1 - 0.041 13.2 0.0 0.095 12.0 0.0 1.5 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Pyr_redox PF00070.27 AAS54430.1 - 0.18 12.4 0.8 1 9.9 0.5 2.5 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase PglL_A PF15864.5 AAS54430.1 - 1.2 9.0 6.6 9.9 6.0 1.0 2.5 2 0 0 2 2 2 0 Protein glycosylation ligase QCR10 PF09796.9 AAS54431.2 - 5.8e-24 83.9 0.3 7.9e-24 83.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Tricorn_C1 PF14684.6 AAS54431.2 - 0.19 11.8 0.0 0.27 11.3 0.0 1.1 1 0 0 1 1 1 0 Tricorn protease C1 domain ERM PF00769.19 AAS54432.1 - 0.073 12.9 31.3 0.26 11.1 7.8 3.6 3 0 0 3 3 3 0 Ezrin/radixin/moesin family Stap_Strp_tox_C PF02876.17 AAS54432.1 - 7.2 7.0 8.7 1.6 9.1 3.9 2.3 2 0 0 2 2 2 0 Staphylococcal/Streptococcal toxin, beta-grasp domain TolA_bind_tri PF16331.5 AAS54432.1 - 7.4 6.7 17.2 0.9 9.7 5.6 3.9 3 1 0 3 3 3 0 TolA binding protein trimerisation ICL PF00463.21 AAS54433.2 - 3.1e-167 557.2 0.0 3.7e-167 557.0 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 AAS54433.2 - 4.3e-08 32.9 0.0 9.2e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Mpp10 PF04006.12 AAS54434.2 - 2.2e-05 23.1 11.5 2.7e-05 22.9 11.5 1.2 1 0 0 1 1 1 1 Mpp10 protein CDC45 PF02724.14 AAS54434.2 - 0.00037 18.9 11.3 0.00046 18.6 11.3 1.1 1 0 0 1 1 1 1 CDC45-like protein CobT PF06213.12 AAS54434.2 - 0.00051 19.5 15.9 0.00076 19.0 15.9 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DUF913 PF06025.12 AAS54434.2 - 0.0019 17.3 0.7 0.0025 16.8 0.7 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) SDA1 PF05285.12 AAS54434.2 - 0.0049 16.4 20.6 0.0066 15.9 20.6 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 AAS54434.2 - 0.012 13.9 25.4 0.016 13.5 25.4 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 AAS54434.2 - 0.092 11.5 4.5 0.11 11.2 4.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TFIIA PF03153.13 AAS54434.2 - 0.13 12.2 21.2 0.17 11.8 21.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 AAS54434.2 - 0.17 11.7 6.6 0.25 11.1 6.6 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF3337 PF11816.8 AAS54434.2 - 0.21 11.4 1.4 0.29 11.0 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3337) BUD22 PF09073.10 AAS54434.2 - 0.21 10.9 20.5 0.31 10.3 20.5 1.2 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 AAS54434.2 - 0.23 10.2 5.5 0.31 9.8 5.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Vfa1 PF08432.10 AAS54434.2 - 0.29 11.4 6.8 0.46 10.8 6.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pox_Ag35 PF03286.14 AAS54434.2 - 0.44 10.3 12.4 0.92 9.3 12.4 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 AAS54434.2 - 0.48 8.5 43.7 0.61 8.1 43.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Zip PF02535.22 AAS54434.2 - 0.86 8.8 1.6 1.1 8.4 1.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF100_C PF13299.6 AAS54434.2 - 1.2 9.3 4.2 2.1 8.5 4.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RPN2_C PF18004.1 AAS54434.2 - 2.8 7.9 8.6 4.6 7.1 8.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Paf1 PF03985.13 AAS54434.2 - 2.8 6.8 18.1 4.2 6.3 18.1 1.2 1 0 0 1 1 1 0 Paf1 NPR3 PF03666.13 AAS54434.2 - 3.4 6.3 6.7 4.5 5.9 6.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Roughex PF06020.11 AAS54434.2 - 6.2 5.8 19.6 9.3 5.2 19.6 1.1 1 0 0 1 1 1 0 Drosophila roughex protein AAA_33 PF13671.6 AAS54435.1 - 1.7e-06 28.2 0.0 0.0018 18.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AAS54435.1 - 5.8e-05 23.6 0.0 0.005 17.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AAS54435.1 - 6.4e-05 23.4 0.0 0.00011 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS54435.1 - 0.00018 21.8 0.0 0.00064 20.0 0.0 1.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 AAS54435.1 - 0.00019 21.4 0.0 0.0074 16.2 0.0 2.4 2 1 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 AAS54435.1 - 0.00022 20.5 0.0 0.0012 18.1 0.0 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_5 PF07728.14 AAS54435.1 - 0.00081 19.4 0.0 0.0018 18.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) KTI12 PF08433.10 AAS54435.1 - 0.00098 18.6 0.0 0.0015 18.0 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 AAS54435.1 - 0.0013 18.0 0.0 0.0029 16.9 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin PRK PF00485.18 AAS54435.1 - 0.0014 18.4 0.0 0.96 9.2 0.0 2.4 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 AAS54435.1 - 0.0031 17.9 0.0 0.006 17.0 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_17 PF13207.6 AAS54435.1 - 0.0091 16.4 0.0 0.022 15.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AAS54435.1 - 0.025 14.3 0.0 0.041 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AAS54435.1 - 0.035 13.6 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region 6PF2K PF01591.18 AAS54435.1 - 0.035 13.4 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 AAS54435.1 - 0.036 14.1 0.0 0.1 12.7 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase Mg_chelatase PF01078.21 AAS54435.1 - 0.049 13.0 0.0 0.079 12.3 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI GTP_EFTU PF00009.27 AAS54435.1 - 0.056 13.0 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS54435.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase Viral_helicase1 PF01443.18 AAS54435.1 - 0.074 12.8 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 AAS54435.1 - 0.081 11.9 0.0 0.15 11.0 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB KAP_NTPase PF07693.14 AAS54435.1 - 0.089 12.0 0.0 0.089 12.0 0.0 1.1 1 0 0 1 1 1 0 KAP family P-loop domain APS_kinase PF01583.20 AAS54435.1 - 0.089 12.7 0.0 0.22 11.4 0.0 1.6 2 0 0 2 2 1 0 Adenylylsulphate kinase Ploopntkinase3 PF18751.1 AAS54435.1 - 0.089 12.7 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_28 PF13521.6 AAS54435.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AAS54435.1 - 0.12 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ATP_bind_1 PF03029.17 AAS54435.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.6 2 0 0 2 2 1 0 Conserved hypothetical ATP binding protein MCM PF00493.23 AAS54435.1 - 0.15 11.1 0.0 0.27 10.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_29 PF13555.6 AAS54435.1 - 0.16 11.7 0.0 0.36 10.6 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 AAS54435.1 - 0.18 11.7 0.0 0.34 10.8 0.0 1.4 1 0 0 1 1 1 0 NTPase ETF PF01012.21 AAS54436.1 - 7.7e-38 130.2 2.4 1.3e-37 129.5 2.4 1.3 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 AAS54436.1 - 3.9e-34 116.5 0.2 7.7e-34 115.6 0.2 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain Transcrip_reg PF01709.20 AAS54437.1 - 2.1e-77 259.8 1.2 2.4e-77 259.6 1.2 1.0 1 0 0 1 1 1 1 Transcriptional regulator ATP-synt_F PF01990.17 AAS54438.1 - 7.5e-33 112.7 0.2 8.5e-33 112.5 0.2 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit CTV_P13 PF06922.11 AAS54438.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Citrus tristeza virus P13 protein fn3_2 PF16893.5 AAS54439.2 - 3.4e-38 129.7 0.5 6.1e-38 128.9 0.5 1.4 1 0 0 1 1 1 1 Fibronectin type III domain CHS5_N PF16892.5 AAS54439.2 - 2e-23 82.0 0.2 3.5e-23 81.3 0.2 1.4 1 0 0 1 1 1 1 Chitin biosynthesis protein CHS5 N-terminus BRCT PF00533.26 AAS54439.2 - 1.6e-11 44.4 0.0 4.4e-11 43.0 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain fn3 PF00041.21 AAS54439.2 - 5.4e-06 26.7 0.1 1.3e-05 25.4 0.1 1.6 1 0 0 1 1 1 1 Fibronectin type III domain DUF3006 PF11213.8 AAS54439.2 - 0.00016 21.8 0.1 0.0005 20.2 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3006) PTCB-BRCT PF12738.7 AAS54439.2 - 0.0012 18.8 0.0 0.0022 17.9 0.0 1.5 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 AAS54439.2 - 0.055 13.9 0.0 0.14 12.6 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Aminotran_3 PF00202.21 AAS54440.1 - 1.3e-101 340.3 0.0 1.4e-101 340.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Pyridox_oxase_2 PF12766.7 AAS54441.2 - 2.6e-30 105.0 0.0 5e-30 104.1 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AAS54441.2 - 0.13 12.4 0.0 0.36 11.0 0.0 1.8 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase Mito_carr PF00153.27 AAS54443.1 - 9.4e-71 233.8 1.5 4.6e-25 87.4 0.3 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Serine_protease PF18405.1 AAS54443.1 - 0.00091 18.5 0.7 2.4 7.2 0.0 3.3 3 1 0 3 3 3 2 Gammaproteobacterial serine protease Gtr1_RagA PF04670.12 AAS54444.1 - 8.9e-68 228.1 0.2 1.2e-67 227.6 0.2 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Arf PF00025.21 AAS54444.1 - 0.0028 17.1 0.1 0.0072 15.8 0.0 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family AAA_14 PF13173.6 AAS54444.1 - 0.038 14.0 0.0 0.081 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain TYW3 PF02676.14 AAS54445.1 - 7e-64 215.1 0.0 8.6e-64 214.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase TYW3 MIF4G PF02854.19 AAS54446.2 - 8.3e-47 159.6 0.7 1.2e-46 159.1 0.7 1.2 1 0 0 1 1 1 1 MIF4G domain eIF_4G1 PF12152.8 AAS54446.2 - 8.9e-23 80.3 1.0 2.9e-22 78.6 1.0 2.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 4G1 AAA PF00004.29 AAS54447.1 - 3.3e-43 147.3 0.0 6.2e-43 146.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS54447.1 - 1.1e-14 54.0 0.5 3e-14 52.5 0.0 2.0 3 0 0 3 3 1 1 AAA+ lid domain AAA_2 PF07724.14 AAS54447.1 - 9.2e-07 29.1 0.0 2e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Prot_ATP_ID_OB PF16450.5 AAS54447.1 - 1.3e-06 28.2 2.5 3.1e-06 27.1 2.5 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 AAS54447.1 - 1.9e-06 27.9 0.0 1.2e-05 25.3 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AAS54447.1 - 2.1e-05 24.9 0.0 0.00032 21.1 0.0 2.4 1 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AAS54447.1 - 3.4e-05 24.1 0.2 0.006 16.9 0.2 2.5 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 AAS54447.1 - 8.9e-05 22.3 0.0 0.00022 21.0 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_18 PF13238.6 AAS54447.1 - 0.00091 19.8 0.0 0.022 15.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AAS54447.1 - 0.0015 18.3 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 AAS54447.1 - 0.0021 18.2 0.0 0.0049 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AAS54447.1 - 0.0044 17.3 0.0 0.0087 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 AAS54447.1 - 0.0065 16.3 0.0 0.019 14.8 0.0 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 AAS54447.1 - 0.01 15.2 0.2 0.028 13.8 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 AAS54447.1 - 0.01 15.1 0.0 0.028 13.6 0.0 1.7 1 1 0 1 1 1 0 TIP49 P-loop domain DUF2072 PF09845.9 AAS54447.1 - 0.011 15.9 0.2 0.024 14.9 0.2 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein PhoH PF02562.16 AAS54447.1 - 0.015 14.7 0.0 0.077 12.4 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.6 AAS54447.1 - 0.018 15.1 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AAS54447.1 - 0.019 14.9 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Tropomyosin PF00261.20 AAS54447.1 - 0.025 14.0 1.7 0.074 12.4 0.4 2.1 2 0 0 2 2 2 0 Tropomyosin AAA_24 PF13479.6 AAS54447.1 - 0.025 14.3 0.0 0.19 11.4 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF3372 PF11852.8 AAS54447.1 - 0.027 14.0 0.2 0.048 13.2 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3372) Sigma54_activat PF00158.26 AAS54447.1 - 0.033 13.9 0.0 0.17 11.6 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 AAS54447.1 - 0.036 14.4 0.0 0.093 13.1 0.0 1.8 1 1 0 1 1 1 0 RNA helicase AAA_19 PF13245.6 AAS54447.1 - 0.042 14.2 0.1 0.65 10.3 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AAS54447.1 - 0.051 13.1 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AAS54447.1 - 0.083 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF815 PF05673.13 AAS54447.1 - 0.087 12.0 0.0 0.19 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 AAS54447.1 - 0.097 11.9 0.0 0.25 10.6 0.0 1.7 1 0 0 1 1 1 0 Zeta toxin Parvo_NS1 PF01057.17 AAS54447.1 - 0.11 11.6 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_30 PF13604.6 AAS54447.1 - 0.13 12.0 0.0 0.33 10.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Glyco_tran_28_C PF04101.16 AAS54448.1 - 3.4e-21 76.0 0.0 4.9e-21 75.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain E1-E2_ATPase PF00122.20 AAS54449.1 - 4.7e-42 143.6 0.1 1.2e-41 142.2 0.1 1.7 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 AAS54449.1 - 2.6e-33 116.1 0.0 6.3e-33 114.8 0.0 1.7 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AAS54449.1 - 2.6e-09 37.4 5.8 5.7e-06 26.7 1.3 3.6 3 0 0 3 3 3 2 Heavy-metal-associated domain HAD PF12710.7 AAS54449.1 - 3.1e-06 27.7 0.0 6.9e-06 26.6 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AAS54449.1 - 0.001 18.9 0.1 0.031 14.0 0.1 2.5 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Zn_ribbon_SprT PF17283.2 AAS54449.1 - 0.087 12.7 0.1 2.1 8.3 0.0 2.6 2 0 0 2 2 2 0 SprT-like zinc ribbon domain ELFV_dehydrog PF00208.21 AAS54450.1 - 7e-65 219.1 0.0 5e-64 216.3 0.0 2.0 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Bac_GDH PF05088.12 AAS54450.1 - 1.9e-20 72.1 0.0 4.7e-14 51.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial NAD-glutamate dehydrogenase ELFV_dehydrog_N PF02812.18 AAS54450.1 - 0.0094 15.8 0.0 0.04 13.8 0.0 2.0 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain NPR3 PF03666.13 AAS54451.2 - 8.4e-163 542.5 0.0 1.9e-162 541.3 0.0 1.6 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 NPR2 PF06218.11 AAS54451.2 - 0.014 14.2 0.4 1.1 7.9 0.0 2.7 3 0 0 3 3 3 0 Nitrogen permease regulator 2 Orthoreo_P17 PF07272.11 AAS54451.2 - 0.025 14.6 0.0 0.067 13.2 0.0 1.7 1 0 0 1 1 1 0 Orthoreovirus P17 protein RRM_1 PF00076.22 AAS54452.1 - 1.2e-30 105.1 4.5 1.6e-14 53.4 0.4 4.1 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 AAS54452.1 - 0.00028 20.9 0.3 0.72 9.9 0.0 2.4 2 0 0 2 2 2 2 RNA binding motif Nup35_RRM PF05172.13 AAS54452.1 - 0.0016 18.4 0.0 0.16 11.9 0.0 3.0 3 0 0 3 3 3 1 Nup53/35/40-type RNA recognition motif RRM_5 PF13893.6 AAS54452.1 - 0.015 14.9 0.0 0.23 11.1 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 AAS54452.1 - 0.045 13.7 0.6 17 5.5 0.0 3.2 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif CENP-B_dimeris PF09026.10 AAS54452.1 - 0.12 12.7 29.6 0.11 12.8 11.5 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RRM_occluded PF16842.5 AAS54452.1 - 0.13 12.1 0.0 10 6.1 0.0 2.6 2 0 0 2 2 2 0 Occluded RNA-recognition motif FAM176 PF14851.6 AAS54452.1 - 0.37 10.5 13.8 1.7 8.3 4.6 2.5 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 AAS54452.1 - 0.73 9.9 15.0 0.9 9.5 4.7 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal PTPRCAP PF15713.5 AAS54452.1 - 1.1 9.6 13.1 5.2 7.4 3.6 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF4611 PF15387.6 AAS54452.1 - 2.3 8.5 17.3 4 7.7 5.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) LAT PF15234.6 AAS54452.1 - 2.9 7.6 14.3 2.1 8.0 3.1 2.4 2 0 0 2 2 2 0 Linker for activation of T-cells Pox_Ag35 PF03286.14 AAS54452.1 - 3.6 7.3 14.9 3 7.6 4.3 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Cwf_Cwc_15 PF04889.12 AAS54452.1 - 4.2 7.0 21.5 2.4 7.8 6.7 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF3245 PF11595.8 AAS54452.1 - 4.4 7.8 13.5 2.3 8.7 3.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) PBP1_TM PF14812.6 AAS54452.1 - 4.6 7.7 20.3 1.6 9.2 7.0 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 AAS54452.1 - 4.7 5.2 24.8 0.53 8.3 10.5 2.1 2 0 0 2 2 2 0 DNA polymerase phi Myc_N PF01056.18 AAS54452.1 - 5 6.9 9.9 1.8 8.4 2.1 2.3 2 0 0 2 2 2 0 Myc amino-terminal region GP67 PF17634.2 AAS54452.1 - 5.2 7.5 28.3 0.52 10.8 10.7 2.4 2 0 0 2 2 2 0 Gene product 67 FYDLN_acid PF09538.10 AAS54452.1 - 5.5 7.7 19.7 3.9 8.2 6.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PI3K_1B_p101 PF10486.9 AAS54452.1 - 6.1 4.5 6.2 2.9 5.6 1.1 2.0 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sigma70_ner PF04546.13 AAS54452.1 - 6.3 6.6 17.4 0.59 10.0 4.2 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region WRNPLPNID PF15017.6 AAS54452.1 - 7.3 7.6 20.1 13 6.7 3.4 2.5 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box AAA_2 PF07724.14 AAS54454.1 - 5e-46 156.9 0.0 7.7e-45 153.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_lid_9 PF17871.1 AAS54454.1 - 4.4e-29 100.5 5.7 4.9e-29 100.3 0.3 3.2 1 1 1 2 2 2 1 AAA lid domain AAA PF00004.29 AAS54454.1 - 1.4e-23 83.7 0.1 3.1e-14 53.5 0.1 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) ClpB_D2-small PF10431.9 AAS54454.1 - 1.8e-23 82.4 0.9 7.1e-23 80.5 0.9 2.2 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 AAS54454.1 - 1.1e-16 61.1 0.0 2.1e-09 37.5 0.0 2.9 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) Clp_N PF02861.20 AAS54454.1 - 2.2e-12 46.9 4.3 1.4e-08 34.7 0.4 3.6 3 0 0 3 3 3 2 Clp amino terminal domain, pathogenicity island component Sigma54_activat PF00158.26 AAS54454.1 - 1.7e-11 44.1 0.1 2e-08 34.1 0.0 2.9 2 1 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 AAS54454.1 - 2.5e-10 41.0 4.4 0.00063 20.2 0.0 5.4 4 1 1 5 5 5 2 AAA ATPase domain AAA_22 PF13401.6 AAS54454.1 - 4.5e-08 33.5 4.0 0.001 19.4 0.1 4.2 3 2 0 3 3 2 2 AAA domain TniB PF05621.11 AAS54454.1 - 3.7e-06 26.5 0.1 0.0036 16.7 0.1 4.1 2 1 0 2 2 2 1 Bacterial TniB protein AAA_14 PF13173.6 AAS54454.1 - 6.3e-06 26.2 0.0 0.18 11.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AAS54454.1 - 1.3e-05 24.6 0.9 0.13 11.5 0.0 3.2 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_24 PF13479.6 AAS54454.1 - 2.4e-05 24.2 0.0 0.017 14.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 AAS54454.1 - 5.9e-05 22.6 0.0 0.63 9.4 0.0 3.6 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 AAS54454.1 - 0.00017 21.2 0.0 0.11 12.1 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region NACHT PF05729.12 AAS54454.1 - 0.00021 21.3 0.0 0.49 10.3 0.0 3.0 2 0 0 2 2 2 2 NACHT domain AAA_3 PF07726.11 AAS54454.1 - 0.00026 20.8 0.0 0.34 10.8 0.0 3.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 AAS54454.1 - 0.00039 20.6 1.4 0.032 14.4 0.0 3.7 4 1 0 4 4 2 1 AAA domain ATPase_2 PF01637.18 AAS54454.1 - 0.00082 19.3 2.6 2.1 8.2 0.1 3.9 3 1 1 4 4 3 1 ATPase domain predominantly from Archaea Zeta_toxin PF06414.12 AAS54454.1 - 0.0013 18.0 0.1 0.072 12.4 0.0 2.9 4 0 0 4 4 3 1 Zeta toxin AAA_19 PF13245.6 AAS54454.1 - 0.0032 17.8 0.1 0.16 12.3 0.0 3.1 2 2 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AAS54454.1 - 0.0052 16.5 0.0 1.4 8.6 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein TsaE PF02367.17 AAS54454.1 - 0.012 15.7 0.0 1.4 8.9 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 AAS54454.1 - 0.017 14.8 0.0 0.17 11.5 0.0 2.5 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain Torsin PF06309.11 AAS54454.1 - 0.025 14.7 0.0 0.11 12.7 0.0 2.0 2 0 0 2 2 1 0 Torsin Roc PF08477.13 AAS54454.1 - 0.025 14.8 0.0 13 6.0 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 AAS54454.1 - 0.047 14.1 0.0 19 5.7 0.0 2.7 2 0 0 2 2 2 0 RNA helicase APS_kinase PF01583.20 AAS54454.1 - 0.056 13.3 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 Adenylylsulphate kinase PEPCK_ATP PF01293.20 AAS54454.1 - 0.06 12.0 0.0 0.1 11.2 0.0 1.3 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase AAA_23 PF13476.6 AAS54454.1 - 0.061 13.8 6.3 2 8.8 2.6 3.6 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 AAS54454.1 - 0.099 13.2 1.8 1.4 9.5 0.0 3.2 3 0 0 3 3 2 0 AAA domain ABC_tran PF00005.27 AAS54454.1 - 0.19 12.2 2.3 5.8 7.4 0.0 3.3 2 1 0 3 3 3 0 ABC transporter Spc7 PF08317.11 AAS54454.1 - 0.47 9.3 10.8 0.9 8.4 10.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein Macoilin PF09726.9 AAS54454.1 - 2.3 6.7 12.2 3.4 6.1 12.2 1.1 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 AAS54454.1 - 7.4 4.4 5.5 11 3.8 5.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sod_Cu PF00080.20 AAS54456.2 - 3.2e-08 33.8 0.0 6e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Copper/zinc superoxide dismutase (SODC) Fe-S_biosyn PF01521.20 AAS54457.1 - 1.9e-18 66.7 0.0 2.9e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis DUF3853 PF12964.7 AAS54457.1 - 0.027 14.6 0.0 0.065 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) DUF3418 PF11898.8 AAS54457.1 - 0.095 11.4 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3418) Med3 PF11593.8 AAS54457.1 - 0.15 11.2 5.8 0.23 10.6 5.8 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Creatinase_N_2 PF16189.5 AAS54458.1 - 2.6e-42 144.7 0.9 5.9e-42 143.5 0.3 1.9 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 AAS54458.1 - 4e-41 141.0 0.0 6.1e-41 140.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 AAS54458.1 - 1.5e-22 79.4 0.5 5.1e-22 77.7 0.2 2.1 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 AAS54458.1 - 7.7e-11 42.8 0.0 6.3e-08 33.3 0.0 2.5 2 1 0 2 2 2 2 Creatinase/Prolidase N-terminal domain Cofilin_ADF PF00241.20 AAS54459.1 - 2.3e-13 50.0 0.0 2.6e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Ribosomal_S13_N PF08069.12 AAS54460.1 - 1.5e-27 95.4 0.5 2.9e-27 94.5 0.5 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AAS54460.1 - 6.7e-15 55.1 0.8 1.2e-14 54.3 0.4 1.5 2 0 0 2 2 2 1 Ribosomal protein S15 HAUS-augmin3 PF14932.6 AAS54461.1 - 0.015 14.9 2.8 0.025 14.1 2.8 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 SbcD_C PF12320.8 AAS54461.1 - 0.019 15.2 0.5 0.16 12.3 0.9 2.2 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain OPT PF03169.15 AAS54463.1 - 1.5e-137 459.8 41.0 1.8e-137 459.6 41.0 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.6 AAS54463.1 - 0.047 14.0 0.1 0.047 14.0 0.1 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF4064) Zip PF02535.22 AAS54463.1 - 3.1 6.9 4.8 12 5.0 0.5 3.2 3 0 0 3 3 3 0 ZIP Zinc transporter MFS_1 PF07690.16 AAS54464.2 - 1.5e-34 119.5 13.7 2e-34 119.1 13.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF5455 PF17537.2 AAS54464.2 - 9.7 6.7 14.5 0.12 12.7 2.5 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5455) WW PF00397.26 AAS54465.1 - 2.9e-10 40.0 0.8 5.2e-10 39.2 0.8 1.4 1 0 0 1 1 1 1 WW domain Pericardin_rpt PF07054.11 AAS54465.1 - 5e-09 36.1 63.5 2.8e-07 30.5 30.9 4.4 1 1 2 3 3 3 3 Pericardin like repeat Romo1 PF10247.9 AAS54465.1 - 0.045 14.1 4.2 0.075 13.4 4.2 1.3 1 0 0 1 1 1 0 Reactive mitochondrial oxygen species modulator 1 WD40 PF00400.32 AAS54466.1 - 1.3e-32 111.2 21.0 9.3e-06 26.3 1.1 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat CDC4_D PF16856.5 AAS54466.1 - 1.1e-19 70.0 3.9 2.6e-19 68.8 3.9 1.7 1 0 0 1 1 1 1 Cell division control protein 4 dimerisation domain F-box-like PF12937.7 AAS54466.1 - 5e-10 39.1 0.2 5e-10 39.1 0.2 1.9 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 AAS54466.1 - 3.3e-08 33.2 2.7 5.7e-08 32.4 0.6 2.3 1 1 1 2 2 2 1 F-box domain ANAPC4_WD40 PF12894.7 AAS54466.1 - 0.0002 21.6 0.4 0.13 12.6 0.1 4.4 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PRANC PF09372.10 AAS54466.1 - 0.0056 17.0 0.9 0.012 15.9 0.1 2.0 2 0 0 2 2 2 1 PRANC domain Nup160 PF11715.8 AAS54466.1 - 0.042 12.5 5.2 1.7 7.2 0.1 3.9 2 2 2 4 4 4 0 Nucleoporin Nup120/160 WD40_like PF17005.5 AAS54466.1 - 0.043 13.2 2.0 26 4.0 0.1 3.2 3 0 0 3 3 3 0 WD40-like domain MgtE_N PF03448.17 AAS54466.1 - 0.057 14.0 0.1 0.11 13.1 0.1 1.4 1 0 0 1 1 1 0 MgtE intracellular N domain SMC_N PF02463.19 AAS54467.1 - 3.2e-65 219.7 0.0 6.1e-65 218.7 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AAS54467.1 - 2.8e-26 92.1 0.0 2.1e-25 89.3 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AAS54467.1 - 1.4e-09 38.2 9.1 1.8e-05 24.7 0.0 3.6 4 0 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AAS54467.1 - 1.8e-07 30.8 0.1 4.3e-07 29.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AAS54467.1 - 0.00013 21.8 19.2 0.00013 21.8 19.2 5.1 2 2 2 4 4 4 1 AAA ATPase domain Spc7 PF08317.11 AAS54467.1 - 0.00056 18.9 16.7 0.00056 18.9 16.7 6.5 4 1 3 7 7 6 2 Spc7 kinetochore protein RPW8 PF05659.11 AAS54467.1 - 0.00074 19.2 22.8 0.01 15.5 0.2 5.4 4 2 0 4 4 4 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_13 PF13166.6 AAS54467.1 - 0.00081 18.2 9.5 0.00081 18.2 9.5 5.6 3 2 2 6 6 6 3 AAA domain TPR_MLP1_2 PF07926.12 AAS54467.1 - 0.0025 17.9 18.7 0.0025 17.9 18.7 7.7 5 3 2 7 7 6 2 TPR/MLP1/MLP2-like protein DHR10 PF18595.1 AAS54467.1 - 0.0029 17.6 10.4 0.0029 17.6 10.4 10.0 6 2 3 11 11 10 1 Designed helical repeat protein 10 domain YscO PF07321.12 AAS54467.1 - 0.0061 16.5 12.8 0.0061 16.5 12.8 6.9 5 1 0 6 6 4 1 Type III secretion protein YscO SbcCD_C PF13558.6 AAS54467.1 - 0.065 13.5 0.0 0.3 11.4 0.0 2.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF695 PF05117.12 AAS54467.1 - 0.15 12.3 1.8 0.3 11.3 0.1 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF695) ABC_tran PF00005.27 AAS54467.1 - 0.15 12.6 0.1 0.15 12.6 0.1 5.6 5 2 0 5 5 4 0 ABC transporter Citrate_bind PF16114.5 AAS54467.1 - 0.17 11.3 1.9 0.34 10.4 0.1 2.4 2 0 0 2 2 2 0 ATP citrate lyase citrate-binding eIF-5_eIF-2B PF01873.17 AAS54467.1 - 0.46 10.4 3.4 8.9 6.2 0.0 3.4 3 0 0 3 3 3 0 Domain found in IF2B/IF5 Mrr_N PF14338.6 AAS54467.1 - 1.1 9.4 7.1 3.9 7.7 0.2 3.7 3 0 0 3 3 2 0 Mrr N-terminal domain AAA_22 PF13401.6 AAS54467.1 - 1.2 9.5 6.4 11 6.3 0.0 4.1 4 0 0 4 4 4 0 AAA domain NPV_P10 PF05531.12 AAS54467.1 - 1.2 9.6 32.5 15 6.2 7.6 8.4 7 2 1 8 8 8 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 AAS54467.1 - 4.2 7.4 32.6 0.29 11.2 5.6 6.6 4 1 4 8 8 8 0 Baculovirus polyhedron envelope protein, PEP, C terminus BLM10_mid PF16507.5 AAS54468.2 - 2.2e-165 551.3 14.7 2.2e-165 551.3 14.7 4.4 5 0 0 5 5 5 1 Proteasome-substrate-size regulator, mid region BLM10_N PF16547.5 AAS54468.2 - 1.9e-31 108.2 0.8 6.7e-31 106.4 0.8 2.0 1 0 0 1 1 1 1 Proteasome-substrate-size regulator, N-terminal DUF3437 PF11919.8 AAS54468.2 - 6.7e-24 83.6 0.2 3e-23 81.5 0.0 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3437) Retrotran_gag_2 PF14223.6 AAS54468.2 - 0.0049 16.5 1.7 0.28 10.8 0.1 4.0 5 0 0 5 5 5 1 gag-polypeptide of LTR copia-type ParcG PF10274.9 AAS54468.2 - 0.12 12.5 0.6 0.39 10.8 0.6 1.8 1 0 0 1 1 1 0 Parkin co-regulated protein Ras PF00071.22 AAS54469.1 - 5.7e-63 211.3 0.3 6.8e-63 211.1 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS54469.1 - 1.1e-36 125.7 0.2 1.5e-36 125.2 0.2 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS54469.1 - 1.3e-18 67.1 0.1 1.5e-18 66.8 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS54469.1 - 3e-07 30.0 0.1 3.4e-07 29.8 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AAS54469.1 - 3.6e-07 29.8 0.1 4.3e-07 29.5 0.1 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 AAS54469.1 - 1.5e-06 28.2 0.2 0.036 14.0 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 AAS54469.1 - 3.6e-06 26.6 0.2 3.2e-05 23.6 0.1 2.1 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AAS54469.1 - 4.1e-06 26.9 0.1 7.1e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS54469.1 - 0.00068 19.2 0.1 0.0059 16.1 0.1 2.1 1 1 0 1 1 1 1 Ferrous iron transport protein B MCM PF00493.23 AAS54469.1 - 0.0045 16.1 0.1 0.045 12.8 0.0 2.1 1 1 1 2 2 2 1 MCM P-loop domain G-alpha PF00503.20 AAS54469.1 - 0.02 14.1 1.4 2.1 7.4 0.0 2.5 1 1 1 2 2 2 0 G-protein alpha subunit AAA_7 PF12775.7 AAS54469.1 - 0.025 14.1 0.0 0.077 12.5 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 AAS54469.1 - 0.027 14.7 0.1 0.28 11.5 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 AAS54469.1 - 0.028 14.9 0.0 0.66 10.4 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 AAS54469.1 - 0.048 13.4 0.1 0.15 11.8 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 AAS54469.1 - 0.07 12.8 0.2 1.5 8.4 0.0 2.5 3 1 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 AAS54469.1 - 0.072 13.5 0.1 0.098 13.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF815 PF05673.13 AAS54469.1 - 0.098 11.8 0.1 0.27 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) TniB PF05621.11 AAS54469.1 - 0.12 11.7 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein VTC PF09359.10 AAS54470.1 - 1.9e-92 309.5 0.0 3.6e-92 308.7 0.0 1.5 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 AAS54470.1 - 3e-14 53.8 18.5 0.00015 21.8 0.5 4.2 2 1 2 4 4 4 4 SPX domain DUF202 PF02656.15 AAS54470.1 - 2.7e-09 37.3 5.7 2.7e-09 37.3 5.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) Spc7 PF08317.11 AAS54470.1 - 0.39 9.5 2.3 0.51 9.2 0.6 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein Peptidase_C48 PF02902.19 AAS54471.2 - 3.4e-35 121.9 0.3 3.4e-35 121.9 0.3 1.8 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain SIR2 PF02146.17 AAS54472.1 - 4.4e-53 179.8 0.0 1e-52 178.6 0.0 1.6 2 0 0 2 2 2 1 Sir2 family zf-LYAR PF08790.11 AAS54472.1 - 0.019 14.8 0.5 0.043 13.7 0.5 1.6 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger NFACT-C PF11923.8 AAS54473.2 - 3.3e-31 107.3 1.3 3.3e-31 107.3 1.3 3.6 3 1 1 4 4 4 1 NFACT protein C-terminal domain FbpA PF05833.11 AAS54473.2 - 7.7e-24 84.3 10.0 2.1e-18 66.4 0.0 3.5 3 0 0 3 3 3 2 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 AAS54473.2 - 3.8e-17 62.9 0.3 1.6e-16 60.9 0.0 2.2 2 0 0 2 2 2 1 NFACT protein RNA binding domain ComJ PF11033.8 AAS54473.2 - 0.047 13.4 0.2 7 6.4 0.0 2.9 1 1 1 2 2 2 0 Competence protein J (ComJ) Clat_adaptor_s PF01217.20 AAS54474.1 - 3.4e-13 49.7 0.4 4.4e-13 49.4 0.4 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Bromo_TP PF07524.13 AAS54475.1 - 1e-06 28.7 0.2 1.8e-06 27.8 0.2 1.4 1 0 0 1 1 1 1 Bromodomain associated Ribosom_S30AE_C PF16321.5 AAS54475.1 - 0.047 13.4 0.1 0.097 12.4 0.1 1.5 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus NUC173 PF08161.12 AAS54476.2 - 1.1e-70 237.5 0.9 5.2e-68 228.7 0.1 3.9 5 0 0 5 5 5 2 NUC173 domain HEAT PF02985.22 AAS54476.2 - 7.5e-05 22.7 0.3 2.8 8.4 0.0 4.5 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 AAS54476.2 - 0.091 13.3 1.9 0.55 10.8 0.0 3.4 4 0 0 4 4 4 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 AAS54476.2 - 0.16 12.6 1.1 9.9 6.8 0.0 3.9 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region UME PF08064.13 AAS54476.2 - 0.17 11.8 1.1 16 5.5 0.1 3.9 3 0 0 3 3 3 0 UME (NUC010) domain Ribosomal_S16 PF00886.19 AAS54477.2 - 3.6e-24 84.6 0.1 4.8e-24 84.2 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S16 PDR_assoc PF08370.11 AAS54477.2 - 0.15 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Plant PDR ABC transporter associated Helicase_C_2 PF13307.6 AAS54480.1 - 1.4e-49 168.5 0.1 2.6e-49 167.7 0.1 1.4 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 AAS54480.1 - 3.3e-47 160.4 0.0 6.1e-47 159.5 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 ResIII PF04851.15 AAS54480.1 - 0.00018 21.6 1.8 0.15 12.0 0.0 3.1 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit DEAD PF00270.29 AAS54480.1 - 0.0023 17.7 0.0 0.5 10.1 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_22 PF13401.6 AAS54480.1 - 0.038 14.3 1.1 2 8.7 0.1 2.8 2 0 0 2 2 2 0 AAA domain zf-TFIIIC PF12660.7 AAS54481.2 - 3.6e-07 30.1 0.0 7.6e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Putative zinc-finger of transcription factor IIIC complex ANAPC4_WD40 PF12894.7 AAS54481.2 - 6e-06 26.5 0.2 0.016 15.5 0.0 4.2 3 1 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain NPC1_N PF16414.5 AAS54482.1 - 1.3e-79 267.2 12.4 1.9e-79 266.7 12.4 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Patched PF02460.18 AAS54482.1 - 5.5e-55 186.8 31.1 3.1e-51 174.4 29.8 4.0 2 1 0 2 2 2 1 Patched family Sterol-sensing PF12349.8 AAS54482.1 - 9.5e-40 135.9 9.4 9.5e-40 135.9 9.4 2.4 2 0 0 2 2 2 1 Sterol-sensing domain of SREBP cleavage-activation ACR_tran PF00873.19 AAS54482.1 - 4.8 4.7 19.6 3.9 5.0 0.0 2.2 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family PPR_2 PF13041.6 AAS54483.1 - 2.8e-12 46.6 3.8 0.0001 22.4 0.0 4.1 4 0 0 4 4 4 3 PPR repeat family PPR PF01535.20 AAS54483.1 - 0.013 15.7 8.6 2.1 8.8 0.0 5.3 6 0 0 6 6 6 0 PPR repeat PPR_3 PF13812.6 AAS54483.1 - 0.024 14.7 0.9 5.7 7.1 0.0 2.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Pil1 PF13805.6 AAS54484.1 - 5.8e-125 416.1 0.1 6.7e-125 415.9 0.1 1.0 1 0 0 1 1 1 1 Eisosome component PIL1 PCP_red PF08369.10 AAS54484.1 - 0.037 14.2 0.4 0.18 12.0 0.3 2.3 2 0 0 2 2 2 0 Proto-chlorophyllide reductase 57 kD subunit FtsK_SpoIIIE PF01580.18 AAS54484.1 - 0.062 12.6 0.1 0.097 12.0 0.1 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family Nop10p PF04135.12 AAS54484.1 - 0.94 9.6 3.0 12 6.0 0.1 2.4 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family ThiF PF00899.21 AAS54485.1 - 5.8e-09 35.7 0.4 1.5e-05 24.5 0.4 2.2 2 0 0 2 2 2 2 ThiF family DEAD PF00270.29 AAS54486.1 - 1.8e-40 138.6 0.1 5.4e-40 137.0 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS54486.1 - 8.7e-22 77.6 0.0 6.1e-21 74.8 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AAS54486.1 - 1.8e-12 47.3 0.0 4.7e-12 46.0 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AAS54486.1 - 0.00037 20.5 2.1 0.00076 19.5 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AAS54486.1 - 0.005 16.1 0.0 0.005 16.1 0.0 2.5 3 0 0 3 3 3 1 ERCC3/RAD25/XPB C-terminal helicase UvrD-helicase PF00580.21 AAS54486.1 - 5.8 6.3 9.8 9.9 5.6 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain PseudoU_synth_1 PF01416.20 AAS54487.2 - 1.1e-32 112.6 0.0 8.2e-30 103.4 0.0 2.6 2 0 0 2 2 2 2 tRNA pseudouridine synthase zf-C2H2_3rep PF18868.1 AAS54487.2 - 0.17 12.5 0.0 0.51 11.0 0.0 1.8 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats EAP30 PF04157.16 AAS54488.1 - 3e-51 174.0 0.0 3.3e-51 173.8 0.0 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family DivIVA PF05103.13 AAS54488.1 - 0.062 13.4 0.2 0.15 12.2 0.2 1.5 1 0 0 1 1 1 0 DivIVA protein DUF3892 PF13031.6 AAS54488.1 - 0.084 13.5 0.0 0.16 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) Hat1_N PF10394.9 AAS54489.2 - 1.5e-42 145.6 0.1 3e-42 144.6 0.1 1.5 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 AAS54489.2 - 0.0013 18.9 0.0 0.0022 18.2 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Citrate_synt PF00285.21 AAS54491.1 - 2.7e-88 296.5 0.0 3.3e-88 296.2 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain MmgE_PrpD PF03972.14 AAS54492.1 - 1.8e-148 494.7 0.0 2.2e-148 494.5 0.0 1.0 1 0 0 1 1 1 1 MmgE/PrpD family Nic96 PF04097.14 AAS54493.1 - 3.1e-208 693.2 8.9 4.4e-208 692.7 8.9 1.2 1 0 0 1 1 1 1 Nup93/Nic96 XET_C PF06955.12 AAS54493.1 - 0.19 11.6 0.0 0.54 10.1 0.0 1.8 1 0 0 1 1 1 0 Xyloglucan endo-transglycosylase (XET) C-terminus PPI_Ypi1 PF07491.11 AAS54494.1 - 7.2e-26 89.8 5.8 1.6e-25 88.7 5.8 1.6 1 0 0 1 1 1 1 Protein phosphatase inhibitor DUF4636 PF15468.6 AAS54494.1 - 0.13 11.9 10.7 0.14 11.8 10.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4636) DUF5506 PF17611.2 AAS54494.1 - 0.38 10.6 1.5 0.74 9.7 1.4 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5506) JAB PF01398.21 AAS54495.1 - 1.4e-31 108.9 0.2 1.4e-31 108.9 0.2 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 AAS54495.1 - 3.2e-11 43.6 1.4 3.2e-11 43.6 1.4 1.8 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 AAS54495.1 - 2.3e-07 30.6 0.0 3.8e-07 29.9 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain UPF0172 PF03665.13 AAS54495.1 - 0.032 14.3 0.5 0.12 12.4 0.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) DUF5624 PF18538.1 AAS54495.1 - 0.043 13.9 0.4 0.095 12.8 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) UCH PF00443.29 AAS54496.2 - 9.9e-11 41.6 0.0 2.2e-10 40.5 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AAS54496.2 - 1.9e-08 34.5 0.0 4.2e-08 33.4 0.0 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein Peptidase_M24 PF00557.24 AAS54497.1 - 7.3e-58 195.7 0.0 9.5e-58 195.3 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 AMP_N PF05195.16 AAS54497.1 - 7.5e-21 74.1 0.0 3.2e-20 72.1 0.0 1.9 2 0 0 2 2 2 1 Aminopeptidase P, N-terminal domain CSTF2_hinge PF14327.6 AAS54498.2 - 2.5e-19 69.5 2.2 1e-18 67.5 2.2 2.1 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 CSTF_C PF14304.6 AAS54498.2 - 8e-08 31.7 7.3 3.1e-07 29.9 6.1 2.3 1 1 1 2 2 2 1 Transcription termination and cleavage factor C-terminal ANAPC2 PF08672.11 AAS54498.2 - 1.2 9.7 6.7 0.61 10.6 0.6 2.5 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 RRM_1 PF00076.22 AAS54499.1 - 1.6e-19 69.5 0.0 4e-19 68.2 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CSTF_C PF14304.6 AAS54499.1 - 1.7e-12 46.7 1.2 4e-12 45.5 1.2 1.7 1 0 0 1 1 1 1 Transcription termination and cleavage factor C-terminal CSTF2_hinge PF14327.6 AAS54499.1 - 5.2e-09 36.4 1.3 5.2e-09 36.4 1.3 1.7 2 0 0 2 2 2 1 Hinge domain of cleavage stimulation factor subunit 2 RRM_occluded PF16842.5 AAS54499.1 - 0.0025 17.7 0.0 0.0047 16.8 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AAS54499.1 - 0.18 12.0 0.0 0.63 10.2 0.0 1.9 1 1 0 1 1 1 0 RNA recognition motif TFIIS_M PF07500.14 AAS54500.2 - 2.7e-25 89.0 0.2 2.7e-25 89.0 0.2 1.9 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS), central domain TFIIS_C PF01096.18 AAS54500.2 - 3e-17 62.2 6.4 4.8e-17 61.5 6.4 1.3 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS) Med26 PF08711.11 AAS54500.2 - 1.5e-09 37.7 2.1 3.9e-09 36.4 2.1 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain HypA PF01155.19 AAS54500.2 - 0.64 10.0 3.5 0.29 11.2 0.7 1.8 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PALP PF00291.25 AAS54501.2 - 6.3e-61 206.4 0.0 9.5e-61 205.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 AAS54501.2 - 3.1e-18 66.0 0.1 3.3e-10 40.3 0.0 2.6 2 0 0 2 2 2 2 CBS domain DUF1989 PF09347.10 AAS54502.2 - 1.6e-57 193.8 0.0 2e-57 193.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1989) Dam PF05869.11 AAS54502.2 - 0.043 13.4 0.0 0.071 12.7 0.0 1.3 1 0 0 1 1 1 0 DNA N-6-adenine-methyltransferase (Dam) Snf7 PF03357.21 AAS54503.1 - 1.4e-34 119.2 9.0 1.8e-34 118.8 9.0 1.1 1 0 0 1 1 1 1 Snf7 DUF4756 PF15948.5 AAS54503.1 - 0.0064 16.3 2.1 0.0064 16.3 2.1 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4756) Holin_BhlA PF10960.8 AAS54503.1 - 0.0065 16.4 1.5 8.7 6.4 0.2 3.3 2 1 1 3 3 3 1 BhlA holin family DUF4854 PF16146.5 AAS54503.1 - 0.041 14.2 1.1 0.17 12.2 0.0 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF4854) Exonuc_VII_L PF02601.15 AAS54503.1 - 0.17 11.5 6.4 0.22 11.0 6.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALAD PF00490.21 AAS54504.1 - 8.8e-117 389.8 0.0 1e-116 389.5 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase PITH PF06201.13 AAS54505.1 - 3.9e-36 124.5 0.0 4.9e-36 124.2 0.0 1.1 1 0 0 1 1 1 1 PITH domain TMEM208_SND2 PF05620.11 AAS54507.1 - 0.89 9.3 4.7 8 6.2 0.1 2.1 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 PWI PF01480.17 AAS54509.2 - 0.038 14.3 0.3 0.1 12.9 0.3 1.7 1 0 0 1 1 1 0 PWI domain TSC22 PF01166.18 AAS54509.2 - 0.082 13.2 0.5 0.24 11.7 0.0 2.1 2 0 0 2 2 2 0 TSC-22/dip/bun family FOP_dimer PF09398.10 AAS54509.2 - 0.15 12.4 0.5 1.2 9.4 0.0 2.7 3 0 0 3 3 3 0 FOP N terminal dimerisation domain PALP PF00291.25 AAS54510.1 - 3.1e-71 240.2 0.1 3.6e-71 240.0 0.1 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CTP_transf_like PF01467.26 AAS54511.2 - 1.3e-30 106.5 0.0 1.8e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like UCH PF00443.29 AAS54512.1 - 6.7e-40 137.2 0.0 1.3e-39 136.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-UBP PF02148.19 AAS54512.1 - 3.8e-22 78.4 12.7 3.3e-21 75.4 4.3 2.9 2 0 0 2 2 2 2 Zn-finger in ubiquitin-hydrolases and other protein UCH_1 PF13423.6 AAS54512.1 - 3.9e-16 59.5 2.7 2.2e-15 57.1 0.1 2.5 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 AAS54512.1 - 1.9e-13 50.0 0.0 8.5e-09 35.1 0.0 2.7 2 0 0 2 2 2 2 UBA/TS-N domain zf-UBP_var PF17807.1 AAS54512.1 - 7.7e-09 35.2 13.1 1.2e-07 31.4 7.3 3.4 2 1 0 2 2 2 1 Variant UBP zinc finger ECH_2 PF16113.5 AAS54513.1 - 7.4e-91 305.1 0.0 9.4e-91 304.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 AAS54513.1 - 4e-27 95.1 1.1 1.2e-26 93.5 0.0 2.0 1 1 1 2 2 2 1 Enoyl-CoA hydratase/isomerase FA_desaturase PF00487.24 AAS54514.2 - 2.5e-19 70.1 11.4 4e-19 69.4 11.4 1.3 1 0 0 1 1 1 1 Fatty acid desaturase Lipid_DES PF08557.10 AAS54514.2 - 1.7e-17 62.6 1.8 2.9e-17 61.9 1.8 1.4 1 0 0 1 1 1 1 Sphingolipid Delta4-desaturase (DES) Pkinase PF00069.25 AAS54516.1 - 8.4e-41 140.1 0.5 1.5e-40 139.2 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54516.1 - 2.8e-27 95.7 0.0 4.6e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS54516.1 - 0.0028 16.7 0.0 0.0028 16.7 0.0 1.9 2 0 0 2 2 2 1 Haspin like kinase domain APH PF01636.23 AAS54516.1 - 0.016 15.1 4.3 0.11 12.4 0.1 3.0 2 1 1 3 3 3 0 Phosphotransferase enzyme family ORC2 PF04084.14 AAS54517.2 - 1.9e-103 345.9 0.0 2.2e-103 345.7 0.0 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 2 TFIIS_C PF01096.18 AAS54518.1 - 7.9e-22 76.8 3.1 7.9e-22 76.8 3.1 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 AAS54518.1 - 9.9e-13 47.7 2.4 7.5e-12 44.9 0.7 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit PhnA_Zn_Ribbon PF08274.12 AAS54518.1 - 0.013 15.4 5.7 0.57 10.2 0.2 3.2 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DZR PF12773.7 AAS54518.1 - 0.041 13.9 6.4 0.14 12.2 0.2 2.6 2 1 0 2 2 2 0 Double zinc ribbon IBR PF01485.21 AAS54518.1 - 0.21 11.8 8.7 0.49 10.7 0.2 2.6 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain zf-WRNIP1_ubi PF18279.1 AAS54518.1 - 0.31 11.8 3.1 4.3 8.2 0.0 3.1 3 0 0 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain Zn_Tnp_IS1595 PF12760.7 AAS54518.1 - 0.54 10.3 10.5 0.29 11.1 0.5 2.9 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 AAS54518.1 - 0.57 9.7 0.1 0.57 9.7 0.1 3.9 5 0 0 5 5 5 0 zinc-ribbon domain DUF4379 PF14311.6 AAS54518.1 - 0.6 10.5 0.2 0.6 10.5 0.2 3.0 3 0 0 3 3 3 0 Probable Zinc-ribbon domain zinc_ribbon_4 PF13717.6 AAS54518.1 - 7.6 6.6 10.2 6.9 6.7 0.5 3.6 4 0 0 4 4 4 0 zinc-ribbon domain Coprogen_oxidas PF01218.18 AAS54519.1 - 5.8e-135 448.7 0.0 6.6e-135 448.6 0.0 1.0 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase zf-C2H2 PF00096.26 AAS54520.1 - 2.7e-05 24.4 18.6 0.00037 20.8 2.7 2.5 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS54520.1 - 0.00024 21.4 12.3 0.0018 18.6 2.9 3.1 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 AAS54520.1 - 0.024 14.4 1.9 0.024 14.4 1.9 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_4 PF13894.6 AAS54520.1 - 0.025 15.4 14.9 0.4 11.7 1.5 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger FAP PF07174.11 AAS54522.1 - 0.19 11.2 10.5 0.25 10.8 10.5 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) zf-RING_2 PF13639.6 AAS54523.1 - 1.9e-09 37.7 9.6 2.8e-09 37.2 9.6 1.3 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 AAS54523.1 - 1.4e-07 31.7 10.2 5.4e-07 29.8 10.2 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 AAS54523.1 - 2e-05 24.5 4.4 4.4e-05 23.5 4.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 AAS54523.1 - 0.00011 22.2 7.2 0.00018 21.4 7.2 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 AAS54523.1 - 0.00034 20.4 8.9 0.00051 19.8 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 AAS54523.1 - 0.00087 19.1 10.1 0.0019 18.0 10.1 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 AAS54523.1 - 0.0027 17.4 4.7 0.0055 16.4 4.7 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 AAS54523.1 - 0.0052 16.6 8.1 0.012 15.4 8.1 1.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 AAS54523.1 - 0.0079 16.1 7.5 0.013 15.5 7.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 AAS54523.1 - 0.037 13.9 5.4 0.084 12.8 5.5 1.7 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 AAS54523.1 - 0.051 13.7 8.5 0.11 12.7 8.5 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 AAS54523.1 - 0.06 13.5 7.0 0.38 11.0 7.0 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Tmpp129 PF10272.9 AAS54523.1 - 0.074 12.3 0.6 0.074 12.3 0.6 1.4 2 0 0 2 2 1 0 Putative transmembrane protein precursor Ribosomal_S10 PF00338.22 AAS54524.1 - 7.8e-31 106.2 0.0 1.2e-30 105.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e FtsJ PF01728.19 AAS54525.1 - 8.9e-68 227.9 0.0 1.3e-67 227.3 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 AAS54525.1 - 0.0076 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 AAS54525.1 - 0.18 11.4 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F tRNA-synt_2 PF00152.20 AAS54526.1 - 5.7e-76 255.6 0.2 8.9e-76 254.9 0.2 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS54526.1 - 1.9e-11 43.8 0.1 3.7e-11 42.9 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AAS54526.1 - 3.8e-08 33.1 0.0 0.00028 20.4 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) CRR7 PF12095.8 AAS54526.1 - 0.086 13.3 0.2 1.8 9.0 0.0 3.1 4 0 0 4 4 4 0 Protein CHLORORESPIRATORY REDUCTION 7 AA_permease PF00324.21 AAS54527.1 - 1.7e-124 416.1 36.8 2.1e-124 415.7 36.8 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54527.1 - 9.9e-36 123.5 36.1 1.3e-35 123.0 36.1 1.1 1 0 0 1 1 1 1 Amino acid permease DUF2684 PF10885.8 AAS54527.1 - 2.9 8.1 8.4 3.7 7.7 2.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) AA_permease PF00324.21 AAS54528.1 - 3.6e-124 415.0 29.5 4.1e-124 414.8 29.5 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54528.1 - 1.6e-29 103.1 31.6 1.9e-29 102.8 31.6 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AAS54529.1 - 7.8e-130 433.7 38.4 9.6e-130 433.4 38.4 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54529.1 - 4e-39 134.6 37.7 4.8e-39 134.4 37.7 1.0 1 0 0 1 1 1 1 Amino acid permease Trp_oprn_chp PF09534.10 AAS54529.1 - 0.026 14.3 0.5 0.072 12.9 0.5 1.7 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Slx4 PF09494.10 AAS54531.1 - 4.5e-12 45.7 0.0 7.5e-12 45.0 0.0 1.4 1 0 0 1 1 1 1 Slx4 endonuclease Mcp5_PH PF12814.7 AAS54532.2 - 8.5e-42 142.1 0.0 2.3e-41 140.7 0.0 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology ADIP PF11559.8 AAS54532.2 - 1.2e-05 25.4 13.1 1.2e-05 25.4 13.1 4.8 3 1 1 4 4 4 2 Afadin- and alpha -actinin-Binding bZIP_1 PF00170.21 AAS54532.2 - 0.0016 18.5 3.6 0.0016 18.5 3.6 5.6 3 1 1 4 4 4 1 bZIP transcription factor MetOD2 PF18548.1 AAS54532.2 - 0.0026 17.8 0.4 29 4.8 0.0 5.7 4 0 0 4 4 3 0 Metanogen output domain 2 CLZ PF16526.5 AAS54532.2 - 0.11 12.9 21.0 2.9 8.3 2.3 5.1 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3450 PF11932.8 AAS54532.2 - 0.46 9.8 22.3 1.4 8.1 3.2 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Spectrin PF00435.21 AAS54532.2 - 0.6 10.6 25.5 3.9 8.0 9.0 5.4 3 0 0 3 3 3 0 Spectrin repeat HALZ PF02183.18 AAS54532.2 - 1.7 8.9 26.8 0.04 14.1 2.2 7.9 4 1 2 6 6 6 0 Homeobox associated leucine zipper DcpS_C PF11969.8 AAS54532.2 - 1.8 9.0 5.6 0.98 9.9 0.0 3.7 3 0 0 3 3 2 0 Scavenger mRNA decapping enzyme C-term binding T3SSipB PF16535.5 AAS54532.2 - 3.9 7.9 18.2 1.1 9.7 4.7 4.2 3 0 0 3 3 3 0 Type III cell invasion protein SipB TSC22 PF01166.18 AAS54532.2 - 4.6 7.6 23.7 0.29 11.5 0.1 6.6 5 0 0 5 5 5 0 TSC-22/dip/bun family YabA PF06156.13 AAS54532.2 - 5.3 7.7 26.5 1.1 9.9 3.4 5.3 4 0 0 4 4 3 0 Initiation control protein YabA Seryl_tRNA_N PF02403.22 AAS54532.2 - 6.8 7.0 28.0 0.56 10.5 8.2 4.6 3 0 0 3 3 2 0 Seryl-tRNA synthetase N-terminal domain Cep57_MT_bd PF06657.13 AAS54532.2 - 7.4 7.1 18.3 4.8 7.7 1.5 5.4 3 1 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 MbeD_MobD PF04899.12 AAS54532.2 - 7.7 6.7 20.8 0.27 11.4 1.6 3.9 3 0 0 3 3 3 0 MbeD/MobD like DUF948 PF06103.11 AAS54532.2 - 8.1 6.8 18.9 5.6 7.3 1.8 5.1 4 1 0 4 4 3 0 Bacterial protein of unknown function (DUF948) zf-CCCH PF00642.24 AAS54533.1 - 4.8e-19 67.8 16.5 2.3e-09 36.9 1.2 2.3 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 AAS54533.1 - 1.8e-05 24.7 20.4 0.00074 19.5 2.2 2.4 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 AAS54533.1 - 0.016 15.0 0.5 0.016 15.0 0.5 2.6 3 0 0 3 3 3 0 CCCH-type zinc finger zf-CCCH_2 PF14608.6 AAS54533.1 - 0.2 12.2 13.8 1.8 9.2 0.7 2.4 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Torus PF16131.5 AAS54533.1 - 1.1 10.0 12.3 1.1 10.0 1.2 2.5 1 1 1 2 2 2 0 Torus domain RWD PF05773.22 AAS54534.1 - 1e-23 83.8 0.3 2.1e-23 82.8 0.3 1.6 1 0 0 1 1 1 1 RWD domain DFRP_C PF16543.5 AAS54534.1 - 8.4e-05 23.0 0.5 8.4e-05 23.0 0.5 2.6 2 1 1 3 3 3 1 DRG Family Regulatory Proteins, Tma46 Atrophin-1 PF03154.15 AAS54534.1 - 7.8 4.6 5.7 11 4.2 5.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family ENTH PF01417.20 AAS54535.1 - 1.7e-32 112.1 0.2 2.6e-32 111.5 0.2 1.3 1 0 0 1 1 1 1 ENTH domain Phage_T4_Ndd PF06591.11 AAS54535.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) HD_assoc PF13286.6 AAS54535.1 - 0.53 10.9 2.9 2.8 8.5 0.5 2.3 2 0 0 2 2 2 0 Phosphohydrolase-associated domain ABC_membrane PF00664.23 AAS54536.2 - 9.7e-89 297.6 27.5 1.7e-48 165.6 18.2 2.2 2 0 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 AAS54536.2 - 2.8e-50 170.4 0.0 2.5e-30 105.8 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AAS54536.2 - 2.9e-09 36.7 5.6 0.00096 18.7 0.1 4.1 2 2 1 4 4 4 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AAS54536.2 - 9.9e-06 25.2 0.2 0.015 15.0 0.0 2.6 2 0 0 2 2 2 2 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 AAS54536.2 - 1.6e-05 25.0 0.5 0.16 12.0 0.0 2.7 2 0 0 2 2 2 2 50S ribosome-binding GTPase AAA_16 PF13191.6 AAS54536.2 - 0.00019 21.9 0.1 0.51 10.7 0.0 2.7 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 AAS54536.2 - 0.00041 20.6 0.2 2.1 8.6 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_21 PF13304.6 AAS54536.2 - 0.00083 19.2 0.7 0.031 14.1 0.1 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 AAS54536.2 - 0.00091 19.2 0.1 0.6 10.0 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase AAA_23 PF13476.6 AAS54536.2 - 0.0011 19.5 6.2 0.012 16.1 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_24 PF13479.6 AAS54536.2 - 0.0016 18.2 0.1 0.033 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 AAS54536.2 - 0.013 15.2 0.0 2.6 7.7 0.0 2.8 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_7 PF12775.7 AAS54536.2 - 0.019 14.5 0.0 7.9 6.0 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region MeaB PF03308.16 AAS54536.2 - 0.024 13.6 0.1 1.2 8.1 0.0 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB HTH_45 PF14947.6 AAS54536.2 - 0.036 14.0 0.3 0.11 12.5 0.3 1.8 1 1 0 1 1 1 0 Winged helix-turn-helix Roc PF08477.13 AAS54536.2 - 0.05 13.8 0.4 18 5.6 0.0 3.5 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Sigma54_activat PF00158.26 AAS54536.2 - 0.054 13.2 0.0 8.5 6.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_15 PF13175.6 AAS54536.2 - 0.06 13.0 3.5 0.075 12.7 0.1 2.5 3 0 0 3 3 3 0 AAA ATPase domain DUF87 PF01935.17 AAS54536.2 - 0.065 13.3 7.2 0.4 10.8 0.1 3.3 3 0 0 3 3 3 0 Helicase HerA, central domain Dynamin_N PF00350.23 AAS54536.2 - 0.072 13.1 2.6 1 9.4 0.0 2.6 3 0 0 3 3 2 0 Dynamin family AAA_25 PF13481.6 AAS54536.2 - 0.097 12.2 0.0 7.2 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 AAS54537.1 - 1.4e-66 224.6 0.0 3e-66 223.5 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54537.1 - 3.6e-31 108.4 0.0 6.7e-31 107.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 AAS54537.1 - 3.5e-06 26.2 0.1 5.4e-06 25.6 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 AAS54537.1 - 9.4e-05 22.4 3.3 0.0015 18.5 0.0 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 AAS54537.1 - 0.00014 21.2 0.2 0.00062 19.2 0.2 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AAS54537.1 - 0.026 13.9 0.0 0.35 10.1 0.0 2.3 2 0 0 2 2 2 0 Kinase-like RIO1 PF01163.22 AAS54537.1 - 0.073 12.7 0.9 0.086 12.4 0.0 1.6 2 0 0 2 2 2 0 RIO1 family FTA2 PF13095.6 AAS54537.1 - 0.075 12.6 0.0 0.075 12.6 0.0 1.9 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 AAS54537.1 - 0.094 11.5 0.4 0.41 9.4 0.0 1.9 2 0 0 2 2 2 0 Fungal protein kinase Androgen_recep PF02166.16 AAS54537.1 - 0.97 8.2 10.6 1.3 7.8 10.6 1.1 1 0 0 1 1 1 0 Androgen receptor CK1gamma_C PF12605.8 AAS54537.1 - 2.2 9.5 8.5 3.6 8.8 8.5 1.3 1 0 0 1 1 1 0 Casein kinase 1 gamma C terminal Spt20 PF12090.8 AAS54537.1 - 9.4 5.8 15.1 16 5.0 15.1 1.2 1 0 0 1 1 1 0 Spt20 family Flocculin_t3 PF13928.6 AAS54538.1 - 2.9e-11 43.7 14.6 2.9e-11 43.7 14.6 2.9 3 0 0 3 3 3 1 Flocculin type 3 repeat BTB_2 PF02214.22 AAS54539.2 - 3.7e-10 40.0 0.1 1.6e-05 25.2 0.1 2.7 2 1 0 2 2 2 2 BTB/POZ domain CBM_14 PF01607.24 AAS54539.2 - 0.35 11.1 0.0 0.35 11.1 0.0 2.5 3 0 0 3 3 3 0 Chitin binding Peritrophin-A domain FIN1 PF17300.2 AAS54540.1 - 1.9e-70 237.2 3.4 2.1e-70 237.0 3.4 1.0 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 KIX_2 PF16987.5 AAS54541.1 - 0.0013 18.7 0.1 0.0055 16.7 0.0 2.0 2 0 0 2 2 2 1 KIX domain DNA_pol_A_exo1 PF01612.20 AAS54541.1 - 0.033 13.9 0.1 0.5 10.1 0.1 2.5 2 1 0 2 2 2 0 3'-5' exonuclease EloA-BP1 PF15870.5 AAS54541.1 - 0.11 12.8 0.1 3.8 7.7 0.0 2.2 1 1 1 2 2 2 0 ElonginA binding-protein 1 CBFD_NFYB_HMF PF00808.23 AAS54542.1 - 2.7e-05 24.4 0.2 4.9e-05 23.5 0.2 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AAS54542.1 - 0.061 13.7 0.1 0.061 13.7 0.1 1.8 2 0 0 2 2 2 0 Core histone H2A/H2B/H3/H4 Nyv1_N PF09426.10 AAS54543.2 - 2.7e-52 176.4 0.2 6.2e-52 175.3 0.1 1.6 2 0 0 2 2 2 1 Vacuolar R-SNARE Nyv1 N terminal Synaptobrevin PF00957.21 AAS54543.2 - 4e-27 93.8 2.7 6.5e-27 93.2 2.7 1.3 1 0 0 1 1 1 1 Synaptobrevin IKBKB_SDD PF18397.1 AAS54543.2 - 0.0044 16.4 2.1 0.0063 15.8 2.1 1.1 1 0 0 1 1 1 1 IQBAL scaffold dimerization domain MCU PF04678.13 AAS54543.2 - 0.019 15.1 0.1 0.032 14.4 0.1 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF2937 PF11157.8 AAS54543.2 - 0.085 12.6 0.7 0.17 11.5 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) FMO-like PF00743.19 AAS54544.1 - 6.9e-26 90.8 0.0 5.2e-15 54.9 0.0 3.1 2 1 1 3 3 3 3 Flavin-binding monooxygenase-like K_oxygenase PF13434.6 AAS54544.1 - 7.2e-11 41.8 0.0 4.3e-07 29.4 0.0 2.3 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_3 PF13738.6 AAS54544.1 - 2.2e-10 40.3 0.0 6.1e-07 29.0 0.0 3.1 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 AAS54544.1 - 6e-08 32.3 0.0 0.00058 19.2 0.0 2.8 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 AAS54544.1 - 4.3e-06 26.8 0.4 0.0013 18.7 0.0 2.7 3 0 0 3 3 3 1 FAD-NAD(P)-binding NAD_binding_8 PF13450.6 AAS54544.1 - 0.0005 20.3 0.1 0.0013 18.9 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AAS54544.1 - 0.01 15.4 0.0 0.97 8.9 0.0 2.3 2 0 0 2 2 2 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 AAS54544.1 - 0.013 16.1 0.2 0.16 12.5 0.0 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 AAS54544.1 - 0.019 14.2 0.0 0.056 12.7 0.0 1.7 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Thi4 PF01946.17 AAS54544.1 - 0.077 12.2 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 AAS54544.1 - 0.19 10.4 0.0 4.5 5.9 0.0 2.1 2 0 0 2 2 2 0 HI0933-like protein PHD PF00628.29 AAS54546.1 - 0.0059 16.5 3.4 0.0059 16.5 3.4 2.0 2 0 0 2 2 2 1 PHD-finger zf-CSL PF05207.13 AAS54546.1 - 0.11 12.2 1.8 0.32 10.8 1.8 1.7 1 0 0 1 1 1 0 CSL zinc finger Pinin_SDK_memA PF04696.13 AAS54546.1 - 3.2 7.8 17.8 1.5 8.9 4.4 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Pkinase PF00069.25 AAS54547.2 - 7.7e-69 232.0 1.0 3.8e-63 213.3 0.2 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54547.2 - 4.2e-39 134.4 0.2 2.1e-37 128.9 0.0 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase KA1 PF02149.19 AAS54547.2 - 5.8e-18 64.4 0.0 1.2e-17 63.4 0.0 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 AAS54547.2 - 2.7e-06 26.9 0.0 4e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 AAS54547.2 - 0.00017 21.0 0.1 0.00033 20.1 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 AAS54547.2 - 0.0017 17.4 0.2 0.0063 15.5 0.1 1.9 2 0 0 2 2 2 1 Haspin like kinase domain Pkinase_fungal PF17667.1 AAS54547.2 - 0.0018 17.1 1.7 0.0031 16.3 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 AAS54547.2 - 0.0019 18.2 0.0 0.064 13.2 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family COE1_HLH PF16423.5 AAS54548.1 - 0.082 12.6 0.3 0.16 11.7 0.3 1.5 1 0 0 1 1 1 0 Transcription factor COE1 helix-loop-helix domain DUF2841 PF11001.8 AAS54549.2 - 8.6e-38 129.2 1.1 3.2e-37 127.4 0.3 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2841) Fungal_trans PF04082.18 AAS54550.1 - 1.4e-37 129.2 0.2 2.4e-37 128.4 0.2 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS54550.1 - 1.8e-08 34.3 9.5 3.6e-08 33.4 9.5 1.5 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain DHHC PF01529.20 AAS54554.1 - 3.2e-22 79.1 13.4 3.4e-22 79.0 5.8 2.7 2 1 0 3 3 3 2 DHHC palmitoyltransferase K-cyclin_vir_C PF09080.10 AAS54554.1 - 0.0036 17.7 2.6 0.024 15.1 0.2 2.4 2 0 0 2 2 2 1 K cyclin, C terminal EPSP_synthase PF00275.20 AAS54555.2 - 2.8e-135 451.3 0.0 4.2e-135 450.7 0.0 1.2 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DHQ_synthase PF01761.20 AAS54555.2 - 1e-100 336.3 0.1 5.4e-100 333.9 0.0 2.0 2 0 0 2 2 2 1 3-dehydroquinate synthase DHquinase_I PF01487.15 AAS54555.2 - 5.6e-55 187.1 0.0 1.4e-54 185.7 0.0 1.7 1 0 0 1 1 1 1 Type I 3-dehydroquinase SKI PF01202.22 AAS54555.2 - 1.2e-34 119.8 0.0 1.2e-33 116.5 0.0 2.2 2 0 0 2 2 2 1 Shikimate kinase Shikimate_dh_N PF08501.11 AAS54555.2 - 1.5e-23 82.8 0.0 4.8e-23 81.2 0.0 1.9 2 0 0 2 2 2 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 AAS54555.2 - 1e-11 44.4 0.3 2.4e-11 43.2 0.3 1.7 1 0 0 1 1 1 1 Shikimate 5'-dehydrogenase C-terminal domain Fe-ADH_2 PF13685.6 AAS54555.2 - 4.6e-08 33.1 0.1 9.3e-08 32.1 0.1 1.5 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Shikimate_DH PF01488.20 AAS54555.2 - 1.4e-05 25.2 0.0 3.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase AAA_33 PF13671.6 AAS54555.2 - 0.00052 20.2 0.0 0.0013 18.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain SelB-wing_1 PF09105.10 AAS54555.2 - 0.011 15.6 0.0 3 7.9 0.0 2.6 2 0 0 2 2 2 0 Elongation factor SelB, winged helix DUF2045 PF09741.9 AAS54555.2 - 0.14 11.5 0.0 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2045) Zn_ribbon_17 PF17120.5 AAS54556.2 - 4.7e-23 80.6 13.9 1.2e-22 79.3 13.9 1.7 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type WD40 PF00400.32 AAS54556.2 - 4.5e-05 24.1 20.3 0.038 14.9 0.0 6.0 5 0 0 5 5 5 2 WD domain, G-beta repeat C1_2 PF03107.16 AAS54556.2 - 0.005 17.1 0.5 0.005 17.1 0.5 2.3 2 0 0 2 2 2 1 C1 domain RWD PF05773.22 AAS54556.2 - 0.009 16.3 0.0 0.022 15.0 0.0 1.7 1 0 0 1 1 1 1 RWD domain C1_1 PF00130.22 AAS54556.2 - 0.034 14.0 4.8 0.086 12.7 4.8 1.6 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-rbx1 PF12678.7 AAS54556.2 - 0.074 13.4 8.2 0.2 11.9 8.2 1.7 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 AAS54556.2 - 0.13 12.1 4.9 0.33 10.8 4.9 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_16 PF17034.5 AAS54556.2 - 0.26 11.5 9.1 0.65 10.2 9.1 1.7 1 0 0 1 1 1 0 Zinc-ribbon like family zf-RING_2 PF13639.6 AAS54556.2 - 1.3 9.4 12.6 3.6 8.0 12.6 1.8 1 0 0 1 1 1 0 Ring finger domain adh_short PF00106.25 AAS54557.1 - 5.9e-06 25.9 0.0 2.9e-05 23.6 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AAS54557.1 - 0.0036 16.9 0.0 0.15 11.6 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase CH PF00307.31 AAS54558.2 - 1e-79 263.8 0.1 1.2e-19 70.4 0.0 4.2 4 0 0 4 4 4 4 Calponin homology (CH) domain EF-hand_7 PF13499.6 AAS54558.2 - 1.5e-07 31.7 0.7 9.8e-07 29.1 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 AAS54558.2 - 0.00023 20.5 1.5 0.31 10.7 0.0 3.6 3 0 0 3 3 3 1 EF hand CAMSAP_CH PF11971.8 AAS54558.2 - 0.0022 17.8 0.0 0.65 9.9 0.0 3.4 3 0 0 3 3 3 1 CAMSAP CH domain EF-hand_6 PF13405.6 AAS54558.2 - 0.0035 17.1 0.5 3.5 7.8 0.0 3.6 3 0 0 3 3 3 1 EF-hand domain Laminin_II PF06009.12 AAS54558.2 - 0.079 13.0 0.5 9.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Laminin Domain II RRN3 PF05327.11 AAS54558.2 - 0.25 9.8 0.3 0.41 9.1 0.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ANAPC9 PF12856.7 AAS54559.1 - 1.3e-08 35.0 0.0 2.4e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 9 CsgA PF17334.2 AAS54559.1 - 0.039 14.7 0.0 0.074 13.8 0.0 1.4 1 0 0 1 1 1 0 Minor curli fiber component A CDC45 PF02724.14 AAS54560.1 - 8.3e-200 665.3 1.5 4.3e-199 662.9 1.5 1.8 1 1 0 1 1 1 1 CDC45-like protein tRNA_int_endo PF01974.17 AAS54562.2 - 4.2e-23 81.2 0.1 7.9e-23 80.3 0.1 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AAS54562.2 - 0.12 12.1 0.4 5.2 6.8 0.4 2.6 2 0 0 2 2 2 0 tRNA intron endonuclease, N-terminal domain AAA_5 PF07728.14 AAS54563.2 - 1.1e-123 407.6 2.5 4.7e-21 75.2 0.0 9.7 9 0 0 9 9 9 9 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 AAS54563.2 - 2.5e-50 169.1 0.2 1.4e-18 67.1 0.0 5.6 5 0 0 5 5 4 3 Midasin AAA lid domain AAA_7 PF12775.7 AAS54563.2 - 7.2e-33 113.6 8.9 8.6e-08 31.9 0.0 6.9 7 0 0 7 7 6 5 P-loop containing dynein motor region AAA_lid_5 PF17865.1 AAS54563.2 - 1.2e-31 108.9 0.0 5e-30 103.7 0.0 3.2 2 0 0 2 2 2 1 Midasin AAA lid domain AAA_3 PF07726.11 AAS54563.2 - 3.5e-31 107.8 0.0 1.5e-10 41.0 0.0 7.6 8 0 0 8 8 7 3 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 AAS54563.2 - 6.2e-26 91.4 4.1 0.0005 20.5 0.1 7.6 7 0 0 7 7 6 5 ATPase family associated with various cellular activities (AAA) AAA_6 PF12774.7 AAS54563.2 - 2.4e-21 76.1 0.3 0.0092 15.0 0.0 9.4 8 1 1 9 9 9 5 Hydrolytic ATP binding site of dynein motor region Dynein_heavy PF03028.15 AAS54563.2 - 3.5e-21 75.5 0.0 0.0005 20.1 0.0 7.9 7 0 0 7 7 7 4 Dynein heavy chain region D6 P-loop domain AAA_16 PF13191.6 AAS54563.2 - 2.5e-19 70.3 11.7 0.0023 18.3 0.0 8.8 7 2 0 7 7 6 5 AAA ATPase domain Sigma54_activat PF00158.26 AAS54563.2 - 3.3e-19 69.2 0.9 0.00024 20.9 0.0 6.7 6 0 0 6 6 6 3 Sigma-54 interaction domain AAA_14 PF13173.6 AAS54563.2 - 2.9e-17 62.9 0.4 0.019 15.0 0.0 8.3 8 1 1 9 9 7 3 AAA domain TsaE PF02367.17 AAS54563.2 - 1.4e-16 60.6 2.5 0.014 15.4 0.0 6.8 6 0 0 6 6 6 4 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 AAS54563.2 - 2.5e-16 60.2 1.0 0.042 14.1 0.0 7.4 7 0 0 7 7 5 4 AAA domain AAA_18 PF13238.6 AAS54563.2 - 8.5e-14 52.2 4.2 0.095 13.2 0.0 7.7 6 0 0 6 6 6 3 AAA domain T2SSE PF00437.20 AAS54563.2 - 9.4e-13 47.8 5.5 0.19 10.7 0.0 6.4 6 0 0 6 6 6 3 Type II/IV secretion system protein ABC_tran PF00005.27 AAS54563.2 - 5e-12 46.5 10.6 0.0016 18.9 0.0 7.2 7 0 0 7 7 6 3 ABC transporter Sigma54_activ_2 PF14532.6 AAS54563.2 - 7.1e-12 45.6 0.3 0.081 13.0 0.0 5.9 5 0 0 5 5 5 3 Sigma-54 interaction domain RNA_helicase PF00910.22 AAS54563.2 - 5.5e-10 39.6 5.0 2 8.8 0.1 7.5 7 0 0 7 7 7 1 RNA helicase Mg_chelatase PF01078.21 AAS54563.2 - 5.7e-10 38.9 2.0 5.6 6.3 0.1 9.6 12 0 0 12 12 11 0 Magnesium chelatase, subunit ChlI Zeta_toxin PF06414.12 AAS54563.2 - 5.9e-10 38.8 5.3 0.18 11.1 0.0 7.3 9 0 0 9 9 6 1 Zeta toxin AAA_33 PF13671.6 AAS54563.2 - 4e-09 36.8 10.0 0.16 12.1 0.0 7.2 7 0 0 7 7 6 3 AAA domain AAA_19 PF13245.6 AAS54563.2 - 5.7e-09 36.5 4.6 1.6 9.1 0.1 6.4 6 0 0 6 6 5 3 AAA domain NACHT PF05729.12 AAS54563.2 - 4e-08 33.3 4.6 1.2 9.0 0.0 6.1 5 0 0 5 5 5 1 NACHT domain TniB PF05621.11 AAS54563.2 - 4.5e-08 32.7 2.3 0.057 12.8 0.0 6.1 6 0 0 6 6 6 2 Bacterial TniB protein RsgA_GTPase PF03193.16 AAS54563.2 - 7.6e-08 32.4 13.0 0.94 9.4 0.0 6.5 7 0 0 7 7 7 4 RsgA GTPase AAA_28 PF13521.6 AAS54563.2 - 7.7e-08 32.7 3.4 0.76 10.0 0.1 6.3 6 0 0 6 6 5 2 AAA domain IstB_IS21 PF01695.17 AAS54563.2 - 8.2e-08 32.2 1.6 3.7 7.2 0.0 6.0 6 0 0 6 6 5 0 IstB-like ATP binding protein AAA_29 PF13555.6 AAS54563.2 - 1e-07 31.6 0.3 2.4 8.0 0.0 5.9 6 0 0 6 6 6 1 P-loop containing region of AAA domain AAA_25 PF13481.6 AAS54563.2 - 1.4e-07 31.3 0.8 0.67 9.5 0.0 5.5 5 0 0 5 5 5 2 AAA domain PduV-EutP PF10662.9 AAS54563.2 - 6.9e-07 29.1 3.6 0.82 9.4 0.0 5.9 6 0 0 6 6 6 1 Ethanolamine utilisation - propanediol utilisation RuvB_N PF05496.12 AAS54563.2 - 2e-06 27.6 5.7 0.52 10.0 0.0 6.2 7 0 0 7 7 7 2 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 AAS54563.2 - 2.2e-06 27.0 1.2 0.022 13.9 0.0 4.9 5 0 0 5 5 5 1 Protein of unknown function (DUF815) Roc PF08477.13 AAS54563.2 - 5.5e-05 23.4 7.6 6.9 6.9 0.1 6.5 6 0 0 6 6 6 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 AAS54563.2 - 8.3e-05 22.6 7.0 8.9 6.2 0.1 6.4 7 0 0 7 7 6 0 Rad17 P-loop domain ResIII PF04851.15 AAS54563.2 - 9.7e-05 22.4 3.7 4.5 7.2 0.0 5.1 4 1 0 4 4 4 0 Type III restriction enzyme, res subunit SRP54 PF00448.22 AAS54563.2 - 9.7e-05 22.1 13.0 4 7.0 0.1 6.2 7 0 0 7 7 6 0 SRP54-type protein, GTPase domain VWA PF00092.28 AAS54563.2 - 0.00025 21.4 0.7 0.00092 19.5 0.7 2.0 1 0 0 1 1 1 1 von Willebrand factor type A domain ATP-synt_ab PF00006.25 AAS54563.2 - 0.00043 20.0 0.0 3.3 7.3 0.0 4.0 2 1 1 3 3 3 1 ATP synthase alpha/beta family, nucleotide-binding domain TIP49 PF06068.13 AAS54563.2 - 0.00069 18.9 1.4 5.6 6.1 0.1 4.9 5 0 0 5 5 5 0 TIP49 P-loop domain MMR_HSR1 PF01926.23 AAS54563.2 - 0.00071 19.6 7.5 8.5 6.5 0.0 6.5 6 0 0 6 6 6 0 50S ribosome-binding GTPase AAA_24 PF13479.6 AAS54563.2 - 0.002 17.9 4.9 26 4.5 0.0 5.9 6 1 0 6 6 5 0 AAA domain PhoH PF02562.16 AAS54563.2 - 0.0036 16.8 0.7 23 4.3 0.0 4.6 5 0 0 5 5 5 0 PhoH-like protein Viral_helicase1 PF01443.18 AAS54563.2 - 0.0052 16.6 3.7 0.95 9.1 0.0 5.2 6 0 0 6 6 4 1 Viral (Superfamily 1) RNA helicase ATPase PF06745.13 AAS54563.2 - 0.011 15.1 1.7 28 3.9 0.0 5.2 5 0 0 5 5 5 0 KaiC cobW PF02492.19 AAS54563.2 - 0.026 14.1 7.1 5.5 6.5 0.0 5.1 5 0 0 5 5 5 0 CobW/HypB/UreG, nucleotide-binding domain AAA_8 PF12780.7 AAS54563.2 - 0.046 13.0 8.7 13 5.0 0.0 5.3 6 0 0 6 6 4 0 P-loop containing dynein motor region D4 NTPase_1 PF03266.15 AAS54563.2 - 0.069 13.1 13.8 4.6 7.1 0.0 5.8 6 0 0 6 6 4 0 NTPase ATP_bind_1 PF03029.17 AAS54563.2 - 0.51 10.1 8.9 37 4.0 0.3 5.2 5 0 0 5 5 5 0 Conserved hypothetical ATP binding protein MobB PF03205.14 AAS54563.2 - 1.9 8.4 6.8 77 3.2 0.1 4.8 5 0 0 5 5 4 0 Molybdopterin guanine dinucleotide synthesis protein B dNK PF01712.19 AAS54563.2 - 2.4 8.0 11.8 8.9 6.1 0.0 5.9 7 0 0 7 7 5 0 Deoxynucleoside kinase TRM PF02005.16 AAS54564.1 - 1.7e-137 458.6 0.0 2.2e-137 458.2 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 AAS54564.1 - 0.00016 21.5 0.1 0.0004 20.2 0.0 1.6 2 0 0 2 2 2 1 Met-10+ like-protein CDH-cyt PF16010.5 AAS54564.1 - 0.16 11.7 0.2 0.3 10.8 0.2 1.3 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase zf-Mss51 PF13824.6 AAS54564.1 - 0.17 12.0 1.9 0.46 10.6 1.9 1.8 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 MFS_1 PF07690.16 AAS54565.2 - 4.1e-49 167.4 36.5 4.1e-49 167.4 36.5 1.7 2 1 0 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS54565.2 - 2.2e-16 59.8 7.8 2.2e-16 59.8 7.8 3.3 3 0 0 3 3 3 1 Sugar (and other) transporter MFS_1_like PF12832.7 AAS54565.2 - 6.4e-06 25.3 4.5 6.4e-06 25.3 4.5 2.4 2 0 0 2 2 2 1 MFS_1 like family TRI12 PF06609.13 AAS54565.2 - 0.089 11.2 10.3 0.12 10.7 10.3 1.3 1 0 0 1 1 1 0 Fungal trichothecene efflux pump (TRI12) Sulfate_transp PF00916.20 AAS54566.1 - 1.9e-119 398.8 14.2 2.3e-119 398.5 14.2 1.1 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AAS54566.1 - 0.0036 16.9 0.0 0.0071 16.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain MFS_MOT1 PF16983.5 AAS54566.1 - 0.038 14.4 0.9 0.038 14.4 0.9 2.6 2 1 0 2 2 2 0 Molybdate transporter of MFS superfamily STAS_2 PF13466.6 AAS54566.1 - 0.07 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 STAS domain ANAPC4 PF12896.7 AAS54567.1 - 2e-23 83.0 1.4 3e-23 82.4 1.4 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 4 SUI1 PF01253.22 AAS54568.2 - 2.4e-19 69.6 0.0 4.4e-19 68.8 0.0 1.5 1 0 0 1 1 1 1 Translation initiation factor SUI1 Pre-PUA PF17832.1 AAS54568.2 - 8.5e-11 42.4 0.6 2.1e-10 41.2 0.2 2.0 2 0 0 2 2 2 1 Pre-PUA-like domain SWIB PF02201.18 AAS54568.2 - 0.00099 18.9 0.0 0.0026 17.6 0.0 1.7 1 0 0 1 1 1 1 SWIB/MDM2 domain Ribosomal_L1 PF00687.21 AAS54569.2 - 7.8e-26 91.1 0.0 8.7e-26 90.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family NYN_YacP PF05991.11 AAS54569.2 - 0.08 12.9 0.1 0.85 9.5 0.0 2.2 2 0 0 2 2 2 0 YacP-like NYN domain Ribosomal_L34 PF00468.17 AAS54570.1 - 5.7e-20 71.0 9.4 8.9e-20 70.4 9.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L34 GEP5 PF17053.5 AAS54571.1 - 4e-76 255.8 0.8 4.6e-76 255.6 0.8 1.0 1 0 0 1 1 1 1 Genetic interactor of prohibitin 5 Securin PF04856.13 AAS54572.1 - 1.2e-33 117.0 2.3 1.5e-33 116.7 2.3 1.1 1 0 0 1 1 1 1 Securin sister-chromatid separation inhibitor DnaJ_C PF01556.18 AAS54573.1 - 9.2e-32 110.2 0.0 1.2e-31 109.8 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AAS54573.1 - 2.1e-24 85.4 1.7 3.6e-24 84.7 1.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AAS54573.1 - 3e-09 37.1 14.7 5.4e-09 36.3 14.7 1.5 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AAS54573.1 - 0.062 13.3 15.9 1.1 9.3 5.6 2.5 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein zinc_ribbon_6 PF14599.6 AAS54573.1 - 0.78 9.8 3.3 0.62 10.1 0.2 2.2 2 1 0 2 2 2 0 Zinc-ribbon Lar_restr_allev PF14354.6 AAS54573.1 - 1.2 9.5 8.1 67 4.0 8.3 2.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar HypA PF01155.19 AAS54573.1 - 3.7 7.6 7.8 24 5.0 0.2 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 AAS54573.1 - 5.5 7.0 9.5 1.6 8.8 2.4 2.5 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Aminotran_1_2 PF00155.21 AAS54574.1 - 5.4e-39 134.4 0.0 8.4e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 AAS54574.1 - 0.1 11.9 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 AAS54574.1 - 0.23 9.9 0.0 0.33 9.4 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Gaa1 PF04114.14 AAS54576.1 - 1e-122 410.8 18.7 3.2e-122 409.1 18.7 1.8 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component CBM_3 PF00942.18 AAS54577.1 - 0.016 15.6 0.0 0.086 13.3 0.0 2.3 1 0 0 1 1 1 0 Cellulose binding domain SMC_N PF02463.19 AAS54578.1 - 8.7e-79 264.0 5.3 2.6e-78 262.5 5.3 2.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AAS54578.1 - 4.7e-25 88.2 0.0 1.6e-24 86.5 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AAS54578.1 - 3.1e-13 50.2 0.6 2.9e-05 24.0 0.1 3.2 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AAS54578.1 - 3.3e-06 27.1 16.0 3.3e-06 27.1 16.0 4.3 2 2 2 4 4 4 1 AAA ATPase domain CENP-F_leu_zip PF10473.9 AAS54578.1 - 9.4e-05 22.5 15.1 9.4e-05 22.5 15.1 8.6 5 2 4 9 9 9 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_29 PF13555.6 AAS54578.1 - 0.00092 18.9 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain MHB PF16525.5 AAS54578.1 - 0.15 12.3 5.8 3.2 8.1 0.4 3.9 3 0 0 3 3 3 0 Haemophore, haem-binding ABC_tran PF00005.27 AAS54578.1 - 1 9.8 0.0 1 9.8 0.0 7.1 3 2 1 5 5 5 0 ABC transporter AAA_23 PF13476.6 AAS54578.1 - 9.5 6.7 110.6 0.11 13.0 43.3 6.4 3 2 1 4 4 4 0 AAA domain Actin PF00022.19 AAS54580.1 - 1.8e-52 178.3 0.0 2.2e-51 174.8 0.0 1.9 1 1 0 1 1 1 1 Actin FGGY_C PF02782.16 AAS54581.2 - 6.3e-44 150.1 0.9 1e-43 149.4 0.9 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AAS54581.2 - 4.9e-22 78.7 0.0 1.2e-21 77.4 0.0 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DEDD_Tnp_IS110 PF01548.17 AAS54581.2 - 0.15 12.0 0.1 0.34 10.8 0.1 1.6 1 0 0 1 1 1 0 Transposase GCR1_C PF12550.8 AAS54582.2 - 4.1e-09 36.6 0.2 7.7e-09 35.8 0.2 1.5 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes Tim54 PF11711.8 AAS54582.2 - 0.94 8.2 0.0 0.94 8.2 0.0 3.3 2 1 1 3 3 3 0 Inner membrane protein import complex subunit Tim54 Merozoite_SPAM PF07133.11 AAS54582.2 - 8.8 6.3 15.3 25 4.8 15.3 1.8 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Rax2 PF12768.7 AAS54584.1 - 8.1e-55 185.6 2.2 5.9e-51 173.0 0.0 4.9 3 2 2 5 5 5 1 Cortical protein marker for cell polarity Kelch_4 PF13418.6 AAS54584.1 - 0.033 14.2 2.1 0.22 11.6 0.1 3.3 3 1 1 4 4 4 0 Galactose oxidase, central domain TIG PF01833.24 AAS54584.1 - 0.45 10.6 2.9 0.76 9.9 0.5 2.8 2 0 0 2 2 2 0 IPT/TIG domain TRAPPC-Trs85 PF12739.7 AAS54585.2 - 2.1e-95 320.1 0.2 4.8e-95 318.9 0.2 1.5 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF4312 PF14189.6 AAS54585.2 - 0.045 13.7 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4312) EMP70 PF02990.16 AAS54586.1 - 2.4e-189 630.3 7.0 2.4e-189 630.3 7.0 1.3 1 1 0 1 1 1 1 Endomembrane protein 70 Tmpp129 PF10272.9 AAS54586.1 - 1.5 8.1 4.8 0.27 10.5 0.6 1.8 1 1 1 2 2 2 0 Putative transmembrane protein precursor DUF2205 PF10224.9 AAS54587.1 - 0.009 16.0 0.5 0.011 15.7 0.5 1.2 1 0 0 1 1 1 1 Short coiled-coil protein DUF416 PF04222.12 AAS54587.1 - 0.075 12.5 0.1 0.084 12.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF416) IIGP PF05049.13 AAS54588.1 - 0.16 11.0 0.1 0.24 10.4 0.1 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) Actin PF00022.19 AAS54589.1 - 1.4e-21 76.6 0.0 1.5e-12 46.9 0.0 2.2 2 0 0 2 2 2 2 Actin Actin_micro PF17003.5 AAS54589.1 - 0.0051 16.1 0.0 0.0071 15.6 0.0 1.1 1 0 0 1 1 1 1 Putative actin-like family Serinc PF03348.15 AAS54590.2 - 4.7e-133 444.2 13.7 5.4e-133 444.1 13.7 1.0 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF334 PF03904.13 AAS54590.2 - 0.14 11.7 0.0 0.25 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF334) DUF4418 PF14387.6 AAS54590.2 - 1.7 8.9 9.9 6.5 7.0 7.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4418) Rad51 PF08423.11 AAS54591.1 - 5.2e-114 379.8 0.3 7.2e-114 379.3 0.0 1.3 2 0 0 2 2 2 1 Rad51 RecA PF00154.21 AAS54591.1 - 1.4e-10 41.1 0.1 1.9e-10 40.6 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AAS54591.1 - 7.5e-08 32.2 0.0 1.1e-07 31.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 AAS54591.1 - 2.5e-07 30.3 0.1 8.9e-07 28.5 0.1 2.0 1 1 0 1 1 1 1 KaiC HHH_5 PF14520.6 AAS54591.1 - 7.7e-05 23.2 0.5 0.00033 21.2 0.1 2.3 2 1 0 2 2 2 1 Helix-hairpin-helix domain PAXNEB PF05625.11 AAS54591.1 - 0.063 12.4 0.0 0.17 11.0 0.0 1.6 2 0 0 2 2 2 0 PAXNEB protein RNA_pol_A_CTD PF03118.15 AAS54591.1 - 0.11 12.2 0.2 0.31 10.8 0.2 1.7 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain AAA_22 PF13401.6 AAS54591.1 - 0.12 12.6 0.2 0.82 9.9 0.0 2.3 3 0 0 3 3 3 0 AAA domain FlgM PF04316.13 AAS54591.1 - 2.1 8.8 3.8 4.7 7.6 0.0 3.3 4 1 0 4 4 4 0 Anti-sigma-28 factor, FlgM Peptidase_M24 PF00557.24 AAS54592.1 - 1.9e-06 27.8 0.2 4.2e-06 26.6 0.2 1.7 1 1 0 1 1 1 1 Metallopeptidase family M24 E1_dh PF00676.20 AAS54593.1 - 3.7e-122 407.0 0.3 4.5e-122 406.7 0.3 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 AAS54593.1 - 0.0015 17.8 0.0 0.0024 17.1 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase KRTAP7 PF15034.6 AAS54593.1 - 0.059 14.3 3.7 0.33 11.9 0.1 3.1 2 2 1 3 3 3 0 KRTAP type 7 family Ste5_C PF12194.8 AAS54594.1 - 3.5e-74 248.9 0.0 5.4e-74 248.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase Fus3-binding zf-RING_2 PF13639.6 AAS54594.1 - 0.0079 16.5 6.4 0.016 15.5 6.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 AAS54594.1 - 0.19 11.7 4.6 0.38 10.7 4.6 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 AAS54594.1 - 0.28 10.9 2.5 0.57 9.9 2.5 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 AAS54594.1 - 0.48 10.4 3.9 1.1 9.3 3.9 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_11 PF17123.5 AAS54594.1 - 1.5 8.6 6.6 3.2 7.6 6.6 1.5 1 0 0 1 1 1 0 RING-like zinc finger PHD PF00628.29 AAS54594.1 - 2.9 7.8 7.2 6.4 6.8 7.2 1.6 1 0 0 1 1 1 0 PHD-finger C1_1 PF00130.22 AAS54594.1 - 6.5 6.7 6.2 1.4 8.8 2.1 1.9 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PH_4 PF15404.6 AAS54595.1 - 1.7e-70 236.6 0.0 3.8e-70 235.4 0.0 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain Spo7_2_N PF15407.6 AAS54595.1 - 9.8e-22 76.4 0.1 2.7e-21 75.0 0.1 1.8 1 0 0 1 1 1 1 Sporulation protein family 7 PH_6 PF15406.6 AAS54595.1 - 0.14 12.5 0.1 1.8 8.9 0.0 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain PH_13 PF16652.5 AAS54595.1 - 0.37 10.6 3.7 2.5 7.9 0.5 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain COPI_assoc PF08507.10 AAS54596.1 - 4.5e-31 107.6 3.7 5e-31 107.4 3.7 1.0 1 0 0 1 1 1 1 COPI associated protein DUF2892 PF11127.8 AAS54596.1 - 7.5 6.7 10.8 4.6 7.4 4.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2892) 14-3-3 PF00244.20 AAS54597.1 - 6.1e-107 356.2 4.5 7e-107 356.0 4.5 1.0 1 0 0 1 1 1 1 14-3-3 protein FlaF PF07309.11 AAS54597.1 - 0.0048 16.9 0.1 0.012 15.6 0.1 1.6 1 0 0 1 1 1 1 Flagellar protein FlaF Paf1 PF03985.13 AAS54597.1 - 0.021 13.9 0.2 0.027 13.5 0.2 1.2 1 0 0 1 1 1 0 Paf1 AAA_12 PF13087.6 AAS54598.2 - 5.8e-58 195.8 0.0 8.2e-58 195.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AAS54598.2 - 6.8e-39 134.2 0.2 3e-20 73.1 0.1 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.6 AAS54598.2 - 6e-13 49.4 0.0 2.5e-11 44.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AAS54598.2 - 7.6e-11 42.1 0.1 1.7e-09 37.7 0.0 2.6 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 AAS54598.2 - 4e-08 33.3 0.2 0.043 13.6 0.0 3.3 3 0 0 3 3 3 3 Viral (Superfamily 1) RNA helicase UvrD-helicase PF00580.21 AAS54598.2 - 0.0012 18.4 0.0 0.0096 15.5 0.0 2.0 2 0 0 2 2 2 1 UvrD/REP helicase N-terminal domain PhoH PF02562.16 AAS54598.2 - 0.0082 15.6 0.0 0.35 10.3 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein UvrD_C_2 PF13538.6 AAS54598.2 - 0.0087 15.9 0.3 0.049 13.5 0.0 2.4 3 0 0 3 3 3 1 UvrD-like helicase C-terminal domain DUF2075 PF09848.9 AAS54598.2 - 0.0099 15.1 0.6 0.29 10.3 0.0 2.5 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 AAS54598.2 - 0.047 14.1 0.1 0.1 13.0 0.1 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AAS54598.2 - 0.14 12.6 0.0 0.47 10.8 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain ATPase_2 PF01637.18 AAS54598.2 - 0.15 12.0 0.0 0.6 10.0 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 AAS54598.2 - 0.15 12.3 0.0 1.2 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain ResIII PF04851.15 AAS54598.2 - 0.16 12.0 0.0 0.35 10.8 0.0 1.5 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TIP49 PF06068.13 AAS54598.2 - 0.25 10.5 0.0 0.46 9.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Methyltransf_25 PF13649.6 AAS54600.1 - 5.6e-17 62.2 0.2 2.1e-16 60.4 0.1 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AAS54600.1 - 7.8e-15 55.3 0.2 2e-14 54.0 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS54600.1 - 1.8e-12 47.8 0.0 2.8e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS54600.1 - 1.3e-11 44.5 0.0 1.8e-11 44.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AAS54600.1 - 3.7e-08 33.0 0.0 6.1e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 AAS54600.1 - 1.5e-07 31.4 0.0 2.6e-07 30.6 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AAS54600.1 - 5.9e-06 25.9 0.0 1.3e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 AAS54600.1 - 9.9e-05 21.9 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.6 AAS54600.1 - 0.001 19.1 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 AAS54600.1 - 0.0012 19.0 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_18 PF12847.7 AAS54600.1 - 0.0013 18.6 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AAS54600.1 - 0.096 12.0 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase PrmA PF06325.13 AAS54600.1 - 0.096 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) PCMT PF01135.19 AAS54600.1 - 0.17 11.6 0.0 0.25 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Glutaredoxin PF00462.24 AAS54601.1 - 6.1e-19 68.0 0.3 1.2e-17 63.8 0.0 2.6 3 0 0 3 3 3 1 Glutaredoxin Thioredoxin PF00085.20 AAS54601.1 - 3.9e-14 52.5 0.5 7e-14 51.7 0.1 1.6 2 0 0 2 2 2 1 Thioredoxin AhpC-TSA PF00578.21 AAS54601.1 - 6.6e-05 22.8 0.0 0.00016 21.5 0.0 1.6 2 0 0 2 2 2 1 AhpC/TSA family Thioredoxin_8 PF13905.6 AAS54601.1 - 9e-05 22.7 0.0 0.029 14.7 0.0 2.6 1 1 1 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 AAS54601.1 - 0.035 13.4 0.0 0.042 13.2 0.0 1.2 1 0 0 1 1 1 0 OST3 / OST6 family, transporter family Redoxin PF08534.10 AAS54601.1 - 0.067 12.9 0.1 5.4 6.7 0.0 2.1 1 1 1 2 2 2 0 Redoxin Thioredoxin_2 PF13098.6 AAS54601.1 - 0.07 13.6 0.0 0.75 10.3 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin-like domain Rad17 PF03215.15 AAS54602.1 - 2.4e-38 131.9 0.0 6.7e-37 127.2 0.0 2.2 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_16 PF13191.6 AAS54602.1 - 1.2e-05 25.7 0.0 3.3e-05 24.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AAS54602.1 - 0.03 14.6 0.0 0.065 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 AAS54602.1 - 0.066 13.8 0.0 0.14 12.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AAS54602.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 AAS54602.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Cytidylate_kin PF02224.18 AAS54602.1 - 0.15 11.8 0.0 0.29 10.8 0.0 1.5 1 0 0 1 1 1 0 Cytidylate kinase AAA_30 PF13604.6 AAS54602.1 - 0.18 11.5 0.0 0.32 10.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sec63 PF02889.16 AAS54603.1 - 9e-149 493.7 4.8 1.1e-83 280.4 0.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 AAS54603.1 - 1.7e-46 158.2 0.1 4.4e-30 104.7 0.2 2.5 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 AAS54603.1 - 2.3e-22 79.8 0.1 7.2e-15 55.4 0.1 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_PWI PF18149.1 AAS54603.1 - 3e-11 43.5 0.0 1.4e-10 41.4 0.0 2.3 1 0 0 1 1 1 1 N-terminal helicase PWI domain Helicase_C PF00271.31 AAS54603.1 - 4.5e-09 36.6 0.0 6.6e-08 32.9 0.0 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 AAS54603.1 - 3.3e-08 33.9 1.3 0.00083 19.6 0.1 4.2 4 0 0 4 4 4 2 AAA domain SNF2_N PF00176.23 AAS54603.1 - 0.0065 15.2 0.1 0.015 14.1 0.1 1.5 1 0 0 1 1 1 1 SNF2 family N-terminal domain UvrD-helicase PF00580.21 AAS54603.1 - 0.1 12.1 0.2 7.7 5.9 0.0 3.2 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 AAS54603.1 - 0.12 12.7 0.0 11 6.3 0.0 3.0 2 0 0 2 2 2 0 AAA domain DEAD_2 PF06733.15 AAS54604.1 - 5.3e-55 185.7 4.5 5.3e-55 185.7 4.5 1.7 2 0 0 2 2 2 1 DEAD_2 HBB PF06777.11 AAS54604.1 - 1.9e-44 151.7 2.5 3.1e-40 137.9 0.6 2.7 2 0 0 2 2 2 2 Helical and beta-bridge domain Helicase_C_2 PF13307.6 AAS54604.1 - 3.4e-44 151.0 0.0 1.2e-43 149.3 0.0 2.0 1 0 0 1 1 1 1 Helicase C-terminal domain ResIII PF04851.15 AAS54604.1 - 4.6e-05 23.5 0.1 0.0011 19.1 0.1 2.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 AAS54604.1 - 0.0015 18.8 1.9 3.9 7.8 0.1 3.5 3 0 0 3 3 3 1 AAA domain DEAD PF00270.29 AAS54604.1 - 0.003 17.3 0.1 0.33 10.7 0.0 2.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 AAS54604.1 - 0.0077 15.7 0.1 0.25 10.7 0.0 2.3 2 0 0 2 2 2 1 PhoH-like protein DUF2075 PF09848.9 AAS54604.1 - 0.041 13.1 0.1 1.2 8.3 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AAS54604.1 - 0.065 12.9 0.1 0.58 9.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain ADK PF00406.22 AAS54605.1 - 8.8e-38 129.8 0.0 1.1e-37 129.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AAS54605.1 - 5.4e-18 65.7 0.0 8.9e-18 65.0 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 AAS54605.1 - 3.3e-11 43.0 0.3 5.5e-11 42.3 0.3 1.4 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 AAS54605.1 - 3.2e-06 27.3 0.0 5.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AAS54605.1 - 0.018 15.6 0.0 0.041 14.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 AAS54605.1 - 0.082 12.3 0.4 0.13 11.7 0.4 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI MutS_V PF00488.21 AAS54606.2 - 2.3e-65 220.2 0.3 3.8e-65 219.5 0.3 1.3 1 0 0 1 1 1 1 MutS domain V MutS_I PF01624.20 AAS54606.2 - 6.6e-33 113.3 0.0 2.6e-32 111.4 0.0 2.0 2 0 0 2 2 2 1 MutS domain I MutS_III PF05192.18 AAS54606.2 - 4.4e-31 108.6 0.1 7.7e-31 107.8 0.1 1.4 1 0 0 1 1 1 1 MutS domain III MutS_IV PF05190.18 AAS54606.2 - 7.4e-14 51.9 0.5 2.3e-13 50.3 0.1 2.1 2 0 0 2 2 2 1 MutS family domain IV MutS_II PF05188.17 AAS54606.2 - 1.3e-12 48.1 0.0 2.8e-12 47.1 0.0 1.5 1 0 0 1 1 1 1 MutS domain II AAA_14 PF13173.6 AAS54606.2 - 0.021 14.9 0.0 1.6 8.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 AAS54606.2 - 0.021 15.3 0.2 0.15 12.5 0.1 2.4 3 0 0 3 3 3 0 AAA domain AAA_29 PF13555.6 AAS54606.2 - 0.024 14.4 0.0 0.067 12.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 AAS54606.2 - 0.091 13.3 0.0 0.32 11.5 0.0 2.0 1 0 0 1 1 1 0 ABC transporter AAA_27 PF13514.6 AAS54606.2 - 0.11 12.1 0.0 0.25 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain JmjC PF02373.22 AAS54607.2 - 2.5e-41 140.7 1.4 6.1e-41 139.4 1.4 1.7 1 0 0 1 1 1 1 JmjC domain, hydroxylase JmjN PF02375.17 AAS54607.2 - 4.2e-15 55.4 1.1 1.4e-14 53.7 1.1 2.0 1 0 0 1 1 1 1 jmjN domain zf-H2C2_2 PF13465.6 AAS54607.2 - 1.2e-06 28.6 7.2 1.2e-06 28.6 7.2 2.5 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2 PF00096.26 AAS54607.2 - 1.3e-05 25.3 15.1 0.0085 16.5 2.6 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AAS54607.2 - 9.4e-05 22.9 14.9 0.067 14.1 4.9 3.4 2 0 0 2 2 2 2 C2H2-type zinc finger Zn-ribbon_8 PF09723.10 AAS54607.2 - 0.0011 19.1 3.8 0.0027 17.8 3.8 1.7 1 0 0 1 1 1 1 Zinc ribbon domain zf-C2H2_6 PF13912.6 AAS54607.2 - 0.0028 17.6 5.3 0.0028 17.6 5.3 2.9 3 0 0 3 3 3 1 C2H2-type zinc finger DZR PF12773.7 AAS54607.2 - 0.044 13.8 1.2 0.11 12.5 1.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 AAS54607.2 - 0.17 11.9 0.1 0.34 10.9 0.1 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 AAS54607.2 - 0.18 11.5 3.6 9.3 5.9 0.2 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zinc_ribbon_5 PF13719.6 AAS54607.2 - 0.28 11.0 1.4 0.67 9.8 1.4 1.6 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 AAS54607.2 - 0.3 11.4 12.0 0.23 11.8 4.5 2.9 1 1 1 2 2 2 0 Zinc-finger double-stranded RNA-binding CpXC PF14353.6 AAS54607.2 - 0.56 10.3 2.1 24 5.0 0.1 2.4 1 1 0 2 2 2 0 CpXC protein zf-met PF12874.7 AAS54607.2 - 3.9 8.0 8.3 12 6.5 0.8 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PolyA_pol PF01743.20 AAS54608.1 - 8.4e-24 84.4 0.0 1.4e-23 83.7 0.0 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain PolyA_pol_RNAbd PF12627.7 AAS54608.1 - 4.4e-10 39.2 0.0 1.1e-09 37.9 0.0 1.7 1 0 0 1 1 1 1 Probable RNA and SrmB- binding site of polymerase A tRNA_NucTran2_2 PF13735.6 AAS54608.1 - 0.076 13.0 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative PhoLip_ATPase_C PF16212.5 AAS54610.2 - 5.4e-75 252.4 30.9 5.4e-75 252.4 30.9 2.2 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 AAS54610.2 - 2.5e-19 68.7 1.3 2.5e-19 68.7 1.3 2.2 2 0 0 2 2 2 1 Phospholipid-translocating ATPase N-terminal Cation_ATPase PF13246.6 AAS54610.2 - 2.6e-13 49.8 0.1 1.3e-12 47.6 0.0 2.1 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 AAS54610.2 - 2e-10 41.4 6.0 1e-05 26.0 3.4 3.0 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 AAS54610.2 - 1.4e-06 28.0 0.0 5e-06 26.2 0.0 1.9 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 AAS54610.2 - 0.00097 19.0 0.1 0.0044 16.8 0.2 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase UQ_con PF00179.26 AAS54611.1 - 1.3e-47 161.0 0.0 1.5e-47 160.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS54611.1 - 0.0027 17.4 0.0 0.0035 17.0 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 AAS54611.1 - 0.024 14.5 0.1 0.044 13.6 0.1 1.4 1 1 0 1 1 1 0 UEV domain RWD PF05773.22 AAS54611.1 - 0.099 12.9 0.1 0.13 12.6 0.1 1.3 1 0 0 1 1 1 0 RWD domain RRM_1 PF00076.22 AAS54612.1 - 3.4e-85 279.9 4.3 1.9e-20 72.5 0.1 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 AAS54612.1 - 3.8e-18 65.4 7.5 6.9e-18 64.6 1.8 3.3 3 0 0 3 3 3 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 AAS54612.1 - 1.3e-06 28.1 0.0 0.00012 21.8 0.0 3.5 4 0 0 4 4 4 1 Occluded RNA-recognition motif RRM_7 PF16367.5 AAS54612.1 - 0.0013 18.8 1.1 2.8 8.1 0.0 4.7 4 3 0 4 4 4 1 RNA recognition motif Nup35_RRM_2 PF14605.6 AAS54612.1 - 0.0019 18.1 0.5 11 6.2 0.0 4.0 4 0 0 4 4 4 1 Nup53/35/40-type RNA recognition motif NleF_casp_inhib PF16809.5 AAS54612.1 - 0.0053 16.7 0.6 0.014 15.3 0.6 1.7 1 0 0 1 1 1 1 NleF caspase inhibitor DUF4523 PF15023.6 AAS54612.1 - 0.013 15.4 0.0 1.5 8.6 0.0 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF4523) PNPase PF03726.14 AAS54612.1 - 0.026 15.0 0.5 0.026 15.0 0.5 3.2 3 0 0 3 3 3 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Cauli_DNA-bind PF03310.13 AAS54612.1 - 0.041 14.0 0.1 0.12 12.5 0.1 1.8 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein YflT PF11181.8 AAS54612.1 - 0.056 14.0 10.7 9.6 6.8 0.1 3.7 2 1 1 3 3 3 0 Heat induced stress protein YflT OB_RNB PF08206.11 AAS54612.1 - 0.7 9.6 6.7 27 4.5 0.9 3.6 3 1 0 3 3 3 0 Ribonuclease B OB domain GIY-YIG PF01541.24 AAS54612.1 - 2 8.7 4.0 7.4 6.9 0.0 2.9 3 0 0 3 3 3 0 GIY-YIG catalytic domain Transposase_24 PF03004.14 AAS54612.1 - 3.8 7.6 7.1 0.31 11.1 0.2 2.8 4 0 0 4 4 2 0 Plant transposase (Ptta/En/Spm family) SNF2_N PF00176.23 AAS54613.1 - 8.5e-63 212.2 0.1 1.4e-62 211.4 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Cdh1_DBD_1 PF18196.1 AAS54613.1 - 2.4e-43 147.3 2.6 2.4e-43 147.3 2.6 3.6 4 0 0 4 4 4 1 Chromodomain helicase DNA-binding domain 1 DUF4208 PF13907.6 AAS54613.1 - 5.1e-27 94.2 3.0 6.3e-27 93.9 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4208) Chromo PF00385.24 AAS54613.1 - 4.2e-23 81.0 5.8 4.8e-15 55.2 0.4 3.1 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Helicase_C PF00271.31 AAS54613.1 - 3.8e-20 72.3 0.0 9.2e-20 71.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54613.1 - 3.1e-07 30.5 0.0 1.3e-06 28.5 0.0 2.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS54613.1 - 6.6e-07 28.8 0.1 3e-06 26.6 0.1 2.1 1 1 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 Myb_DNA-binding PF00249.31 AAS54613.1 - 7.4e-05 22.9 0.2 0.00034 20.7 0.0 2.2 2 0 0 2 2 1 1 Myb-like DNA-binding domain SLIDE PF09111.10 AAS54613.1 - 0.0031 17.5 2.4 0.0043 17.1 0.0 2.6 3 0 0 3 3 2 1 SLIDE Myb_DNA-bind_6 PF13921.6 AAS54613.1 - 0.0063 16.7 0.0 0.031 14.5 0.0 2.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo_shadow PF01393.19 AAS54613.1 - 0.1 12.7 0.3 1.2 9.3 0.0 2.6 2 0 0 2 2 2 0 Chromo shadow domain CHDCT2 PF08074.11 AAS54613.1 - 0.15 12.2 2.0 0.63 10.2 0.0 3.0 4 0 0 4 4 4 0 CHDCT2 (NUC038) domain PucR PF07905.11 AAS54613.1 - 0.17 12.2 0.0 4.1 7.7 0.0 2.4 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family CDH1_2_SANT_HL1 PF18375.1 AAS54613.1 - 0.88 10.3 4.4 0.42 11.3 0.2 2.8 2 0 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 ABC_tran PF00005.27 AAS54615.1 - 1.3e-33 116.4 0.0 1.9e-15 57.5 0.0 2.5 2 0 0 2 2 2 2 ABC transporter RLI PF04068.15 AAS54615.1 - 3.6e-14 52.3 5.8 1e-13 50.8 5.8 1.9 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 AAS54615.1 - 6.8e-10 39.2 7.5 0.04 13.7 0.1 4.2 2 2 2 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AAS54615.1 - 1.3e-09 37.9 1.7 0.01 15.3 0.2 3.9 2 2 1 3 3 3 2 RecF/RecN/SMC N terminal domain Fer4 PF00037.27 AAS54615.1 - 1.5e-08 34.1 3.2 1.5e-08 34.1 3.2 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 AAS54615.1 - 2e-06 27.6 2.4 2e-06 27.6 2.4 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_16 PF13191.6 AAS54615.1 - 4e-06 27.3 0.0 0.0073 16.7 0.0 2.3 2 0 0 2 2 2 2 AAA ATPase domain RsgA_GTPase PF03193.16 AAS54615.1 - 4.9e-06 26.5 0.0 0.048 13.6 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase AAA_15 PF13175.6 AAS54615.1 - 7.8e-06 25.8 0.2 0.22 11.2 0.0 3.0 2 1 0 3 3 3 2 AAA ATPase domain AAA PF00004.29 AAS54615.1 - 1.3e-05 25.7 0.0 0.045 14.2 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AAS54615.1 - 0.0001 22.6 0.0 0.03 14.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AAS54615.1 - 0.00016 21.3 0.4 0.54 10.0 0.1 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain Rad17 PF03215.15 AAS54615.1 - 0.00022 21.2 0.7 0.54 10.1 0.1 3.0 2 1 1 3 3 3 1 Rad17 P-loop domain AAA_23 PF13476.6 AAS54615.1 - 0.00028 21.4 0.0 0.048 14.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_21 PF14697.6 AAS54615.1 - 0.00045 20.3 11.5 0.0012 18.9 11.5 1.8 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_30 PF13604.6 AAS54615.1 - 0.00066 19.4 0.4 0.044 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain Fer4_2 PF12797.7 AAS54615.1 - 0.00074 19.5 1.0 0.00074 19.5 1.0 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain RNA_helicase PF00910.22 AAS54615.1 - 0.0014 19.0 0.1 0.48 10.8 0.0 2.9 2 0 0 2 2 2 1 RNA helicase Fer4_7 PF12838.7 AAS54615.1 - 0.0018 18.8 1.3 0.0018 18.8 1.3 2.4 1 1 2 3 3 3 2 4Fe-4S dicluster domain NACHT PF05729.12 AAS54615.1 - 0.0021 18.0 1.9 0.12 12.3 0.1 2.5 2 0 0 2 2 2 1 NACHT domain Fer4_10 PF13237.6 AAS54615.1 - 0.0028 17.7 1.3 0.0028 17.7 1.3 2.4 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_28 PF13521.6 AAS54615.1 - 0.0033 17.7 0.2 1.9 8.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AAS54615.1 - 0.004 16.9 0.3 1 9.0 0.1 2.3 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 AAS54615.1 - 0.0041 16.3 0.0 0.9 8.7 0.0 2.2 2 0 0 2 2 2 1 NB-ARC domain Fer4_9 PF13187.6 AAS54615.1 - 0.0046 17.1 11.9 0.0095 16.1 11.9 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_33 PF13671.6 AAS54615.1 - 0.0069 16.6 0.0 2.3 8.4 0.1 2.6 2 0 0 2 2 2 1 AAA domain SRP54 PF00448.22 AAS54615.1 - 0.0081 15.8 2.8 0.36 10.4 0.1 2.3 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_16 PF13484.6 AAS54615.1 - 0.0082 17.1 0.2 0.0082 17.1 0.2 2.6 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain AAA_18 PF13238.6 AAS54615.1 - 0.019 15.5 0.0 10 6.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain MMR_HSR1 PF01926.23 AAS54615.1 - 0.021 14.9 0.0 4.4 7.4 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_25 PF13481.6 AAS54615.1 - 0.024 14.2 0.2 0.27 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 AAS54615.1 - 0.027 14.5 0.1 5.9 6.9 0.0 3.0 3 0 0 3 3 2 0 AAA domain VirE PF05272.11 AAS54615.1 - 0.035 13.9 0.0 5.9 6.6 0.0 2.4 2 0 0 2 2 2 0 Virulence-associated protein E AAA_5 PF07728.14 AAS54615.1 - 0.036 14.0 1.2 0.29 11.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Fer4_17 PF13534.6 AAS54615.1 - 0.052 14.1 1.0 0.052 14.1 1.0 2.4 1 1 1 2 2 2 0 4Fe-4S dicluster domain DLIC PF05783.11 AAS54615.1 - 0.054 12.3 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) TsaE PF02367.17 AAS54615.1 - 0.054 13.5 0.1 0.67 10.0 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_13 PF13166.6 AAS54615.1 - 0.08 11.6 0.2 0.26 9.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Fer4_8 PF13183.6 AAS54615.1 - 0.084 13.3 0.2 0.084 13.3 0.2 2.4 2 0 0 2 2 2 0 4Fe-4S dicluster domain SbcCD_C PF13558.6 AAS54615.1 - 0.097 12.9 0.0 28 5.0 0.0 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_7 PF12775.7 AAS54615.1 - 0.11 12.0 0.1 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 AAS54615.1 - 0.14 11.3 0.0 4.9 6.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Fer4_4 PF12800.7 AAS54615.1 - 0.31 11.7 14.6 0.1 13.1 2.7 2.6 2 0 0 2 2 2 0 4Fe-4S binding domain PduV-EutP PF10662.9 AAS54615.1 - 3.3 7.5 4.4 1.7 8.3 0.2 2.6 3 0 0 3 3 2 0 Ethanolamine utilisation - propanediol utilisation Phosphodiest PF01663.22 AAS54616.2 - 1.5e-15 57.7 0.2 2.3e-15 57.1 0.2 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 AAS54616.2 - 0.0005 19.5 0.6 0.00082 18.8 0.6 1.2 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 AAS54616.2 - 0.039 13.3 0.0 0.091 12.1 0.0 1.6 2 0 0 2 2 2 0 Sulfatase Aminotran_1_2 PF00155.21 AAS54617.2 - 7.1e-65 219.5 0.0 8.4e-65 219.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AAS54617.2 - 8.3e-05 21.7 0.0 0.00013 21.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V OKR_DC_1 PF01276.20 AAS54617.2 - 0.002 16.9 0.0 0.0033 16.2 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain Acetyltransf_1 PF00583.25 AAS54618.1 - 2e-15 57.0 0.0 3e-15 56.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AAS54618.1 - 1.2e-10 41.4 0.1 2.1e-10 40.6 0.1 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AAS54618.1 - 8.3e-06 25.9 0.0 0.0021 18.1 0.0 2.2 1 1 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AAS54618.1 - 2.7e-05 24.5 0.0 4.1e-05 23.9 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AAS54618.1 - 0.018 15.2 0.0 0.032 14.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain UBA PF00627.31 AAS54618.1 - 0.13 12.2 0.1 1.8 8.6 0.1 2.4 2 0 0 2 2 2 0 UBA/TS-N domain FTR1 PF03239.14 AAS54619.1 - 1.7e-89 300.0 12.1 2e-89 299.8 12.1 1.0 1 0 0 1 1 1 1 Iron permease FTR1 family Gly-zipper_Omp PF13488.6 AAS54619.1 - 5.4 7.1 11.2 3.5 7.7 4.1 2.5 2 0 0 2 2 2 0 Glycine zipper Gate PF07670.14 AAS54619.1 - 6.4 7.1 8.6 1.2 9.5 2.6 2.3 2 0 0 2 2 2 0 Nucleoside recognition LSM PF01423.22 AAS54620.1 - 1.2e-18 66.6 0.0 1.3e-18 66.4 0.0 1.0 1 0 0 1 1 1 1 LSM domain BPL_C PF02237.17 AAS54620.1 - 0.044 13.7 0.1 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 Biotin protein ligase C terminal domain Glyco_transf_20 PF00982.21 AAS54622.1 - 4.7e-145 483.9 0.0 6.7e-145 483.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 AAS54622.1 - 1.9e-76 256.3 0.0 3.3e-76 255.5 0.0 1.3 1 0 0 1 1 1 1 Trehalose-phosphatase Glyco_trans_4_4 PF13579.6 AAS54622.1 - 0.0072 16.8 2.3 0.0072 16.8 2.3 2.0 2 0 0 2 2 2 1 Glycosyl transferase 4-like domain DUF5041 PF16444.5 AAS54622.1 - 0.0085 16.4 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5041) Glycos_transf_1 PF00534.20 AAS54622.1 - 0.033 13.7 0.0 0.094 12.2 0.0 1.8 1 1 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AAS54622.1 - 0.046 14.2 0.1 0.19 12.2 0.1 2.0 1 1 0 1 1 1 0 Glycosyl transferases group 1 Cohesin_load PF10345.9 AAS54623.1 - 1.7e-76 257.9 9.9 2.5e-76 257.4 9.9 1.2 1 0 0 1 1 1 1 Cohesin loading factor TBP PF00352.21 AAS54624.1 - 6.2e-68 224.8 0.1 1.1e-32 111.8 0.0 2.1 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 AAS54624.1 - 2e-05 24.6 0.1 0.21 11.8 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF3378) DUF4295 PF14128.6 AAS54624.1 - 0.037 13.8 0.2 0.26 11.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4295) LXG PF04740.12 AAS54625.2 - 0.00073 19.3 6.2 0.0025 17.5 1.2 2.4 2 0 0 2 2 2 1 LXG domain of WXG superfamily CALCOCO1 PF07888.11 AAS54625.2 - 0.0038 16.2 1.4 0.0038 16.2 1.4 2.2 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like OSCP PF00213.18 AAS54625.2 - 0.0043 17.2 6.2 1.1 9.4 0.1 3.8 3 1 1 4 4 4 1 ATP synthase delta (OSCP) subunit Flagellar_rod PF05149.12 AAS54625.2 - 0.0091 15.5 2.0 0.0091 15.5 2.0 2.3 3 0 0 3 3 3 1 Paraflagellar rod protein SlyX PF04102.12 AAS54625.2 - 0.019 15.5 3.0 0.019 15.5 3.0 3.2 3 1 0 3 3 3 0 SlyX Spectrin PF00435.21 AAS54625.2 - 0.022 15.3 1.1 0.022 15.3 1.1 2.8 2 0 0 2 2 2 0 Spectrin repeat DUF489 PF04356.12 AAS54625.2 - 0.034 14.1 1.6 0.064 13.3 1.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF489) DUF4140 PF13600.6 AAS54625.2 - 0.057 13.9 3.8 0.37 11.3 1.7 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) LMBR1 PF04791.16 AAS54625.2 - 0.062 12.2 2.7 0.076 11.9 2.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2935 PF11155.8 AAS54625.2 - 0.11 12.8 4.5 0.13 12.6 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) DUF445 PF04286.12 AAS54625.2 - 0.12 12.2 2.3 0.18 11.6 2.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) HAUS6_N PF14661.6 AAS54625.2 - 0.17 11.4 4.9 0.84 9.2 0.9 2.3 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus TPR_MLP1_2 PF07926.12 AAS54625.2 - 0.26 11.4 15.8 1.2 9.2 1.6 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.6 AAS54625.2 - 0.35 10.9 15.8 0.043 13.8 8.0 2.6 2 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion Jnk-SapK_ap_N PF09744.9 AAS54625.2 - 0.48 10.6 13.7 0.14 12.4 4.2 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF5344 PF17279.2 AAS54625.2 - 0.72 10.5 6.3 0.4 11.3 3.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF3987 PF13148.6 AAS54625.2 - 0.85 8.6 5.2 0.53 9.2 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Cnn_1N PF07989.11 AAS54625.2 - 1.3 9.2 14.4 0.041 14.0 4.4 2.6 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 APG6_N PF17675.1 AAS54625.2 - 1.8 9.1 18.7 0.056 14.0 4.4 3.3 3 0 0 3 3 3 0 Apg6 coiled-coil region TMPIT PF07851.13 AAS54625.2 - 2.8 7.1 7.1 0.33 10.2 0.9 2.1 2 0 0 2 2 2 0 TMPIT-like protein DUF4407 PF14362.6 AAS54625.2 - 3.7 6.8 8.3 25 4.1 8.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec2p PF06428.11 AAS54625.2 - 8.4 6.4 13.8 0.19 11.7 1.2 2.9 3 0 0 3 3 3 0 GDP/GTP exchange factor Sec2p Metallophos PF00149.28 AAS54626.2 - 8.8e-39 134.1 0.2 1.1e-38 133.8 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AAS54626.2 - 0.0014 18.9 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Glyco_hydro_65N PF03636.15 AAS54626.2 - 0.049 13.3 0.0 0.075 12.7 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain ATPase PF06745.13 AAS54627.1 - 1.3e-06 27.9 0.0 2.1e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 AAS54627.1 - 0.00028 20.2 0.0 0.0011 18.2 0.0 1.8 2 0 0 2 2 2 1 Rad51 AAA_24 PF13479.6 AAS54627.1 - 0.00062 19.5 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain RecA PF00154.21 AAS54627.1 - 0.012 15.1 0.0 0.021 14.3 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein AAA_16 PF13191.6 AAS54627.1 - 0.029 14.8 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain MH2 PF03166.14 AAS54628.1 - 0.17 12.1 2.1 3.2 8.0 0.1 2.3 2 1 0 2 2 2 0 MH2 domain UCH PF00443.29 AAS54629.2 - 8.7e-48 163.0 2.0 1.4e-47 162.4 2.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS54629.2 - 4.5e-06 26.5 1.1 8.2e-05 22.3 1.1 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MgtE_N PF03448.17 AAS54629.2 - 0.015 15.9 0.2 0.033 14.8 0.2 1.5 1 0 0 1 1 1 0 MgtE intracellular N domain DUF5624 PF18538.1 AAS54629.2 - 0.18 11.9 0.0 0.47 10.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5624) Aminotran_1_2 PF00155.21 AAS54631.1 - 7.7e-27 94.4 0.0 9.2e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 AAS54631.1 - 1.7e-05 23.8 0.0 7.2e-05 21.7 0.0 1.9 1 1 0 1 1 1 1 Alanine-glyoxylate amino-transferase PET122 PF05476.11 AAS54632.1 - 2.1e-105 351.7 0.0 2.4e-105 351.6 0.0 1.0 1 0 0 1 1 1 1 PET122 60KD_IMP PF02096.20 AAS54633.1 - 7.2e-21 74.8 0.5 7.2e-21 74.8 0.5 1.7 2 0 0 2 2 2 1 60Kd inner membrane protein RhoGAP PF00620.27 AAS54634.1 - 2.1e-40 138.0 0.1 9.1e-40 136.0 0.1 2.2 1 0 0 1 1 1 1 RhoGAP domain RasGEF_N PF00618.20 AAS54634.1 - 8.5e-19 67.7 0.4 8.5e-19 67.7 0.4 4.1 5 0 0 5 5 5 1 RasGEF N-terminal motif RasGEF PF00617.19 AAS54634.1 - 3.9e-14 53.2 7.3 4.5e-14 53.0 0.2 3.8 4 0 0 4 4 4 1 RasGEF domain PH PF00169.29 AAS54634.1 - 1.2e-05 25.8 0.0 4.4e-05 23.9 0.0 2.0 1 0 0 1 1 1 1 PH domain UPF0160 PF03690.13 AAS54635.1 - 5.1e-126 420.6 0.0 5.9e-126 420.4 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) Pet100 PF09803.9 AAS54636.1 - 1.2e-09 38.5 0.7 1.5e-09 38.2 0.1 1.5 2 0 0 2 2 2 1 Pet100 DUF3738 PF12543.8 AAS54636.1 - 0.034 14.3 0.5 0.044 14.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) GvpL_GvpF PF06386.11 AAS54636.1 - 0.11 12.4 2.2 0.12 12.2 2.2 1.0 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF ATPase_gene1 PF09527.10 AAS54636.1 - 0.18 12.0 0.0 0.25 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter Sec34 PF04136.15 AAS54637.1 - 2.4e-39 134.6 2.5 2.4e-39 134.6 2.5 2.9 3 0 0 3 3 3 1 Sec34-like family STAT_alpha PF01017.20 AAS54637.1 - 0.0029 17.5 2.5 0.97 9.3 0.0 3.2 3 0 0 3 3 3 2 STAT protein, all-alpha domain FAM92 PF06730.11 AAS54637.1 - 0.0057 16.1 0.7 0.021 14.3 0.2 2.0 2 0 0 2 2 2 1 FAM92 protein RmuC PF02646.16 AAS54637.1 - 0.092 11.9 2.7 0.32 10.1 0.3 2.3 2 0 0 2 2 2 0 RmuC family IFT57 PF10498.9 AAS54637.1 - 0.21 10.5 3.6 0.1 11.5 0.6 2.0 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 CLZ PF16526.5 AAS54637.1 - 0.44 10.9 3.3 1.9 8.9 0.3 3.4 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels TACC_C PF05010.14 AAS54637.1 - 0.49 10.2 3.9 0.29 10.9 0.6 2.1 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal BLOC1_2 PF10046.9 AAS54637.1 - 0.52 10.7 6.8 0.31 11.3 0.7 3.5 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 H-kinase_dim PF02895.14 AAS54637.1 - 1 9.8 5.2 11 6.5 0.3 3.9 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain RIH_assoc PF08454.11 AAS54637.1 - 1.3 8.9 4.5 0.89 9.4 0.9 2.6 2 1 0 2 2 2 0 RyR and IP3R Homology associated DUF3829 PF12889.7 AAS54637.1 - 2.1 7.8 10.5 0.46 9.9 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3829) Occludin_ELL PF07303.13 AAS54637.1 - 4 8.2 12.4 5.8 7.7 0.7 4.6 4 1 1 5 5 4 0 Occludin homology domain Tfb5 PF06331.12 AAS54638.1 - 4.9e-25 87.3 0.0 5.5e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Transcription factor TFIIH complex subunit Tfb5 Clathrin PF00637.20 AAS54639.1 - 8.9e-30 103.4 0.6 2.7e-29 101.9 0.3 2.0 2 0 0 2 2 2 1 Region in Clathrin and VPS Vps39_1 PF10366.9 AAS54639.1 - 0.0027 18.0 0.1 0.0027 18.0 0.1 2.2 3 0 0 3 3 3 1 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 AAS54639.1 - 0.022 15.6 0.1 0.074 13.9 0.1 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat Fn_bind PF02986.14 AAS54639.1 - 0.17 11.6 4.1 0.4 10.5 4.1 1.5 1 0 0 1 1 1 0 Fibronectin binding repeat DDE_1 PF03184.19 AAS54640.2 - 2.6e-61 206.3 0.0 4.1e-61 205.7 0.0 1.3 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc5 PF03221.16 AAS54640.2 - 6.2e-12 45.4 0.2 1.7e-11 44.0 0.2 1.9 1 0 0 1 1 1 1 Tc5 transposase DNA-binding domain HTH_ABP1_N PF18107.1 AAS54640.2 - 0.00021 20.9 0.0 0.00063 19.4 0.0 1.8 1 0 0 1 1 1 1 Fission yeast centromere protein N-terminal domain HTH_32 PF13565.6 AAS54640.2 - 0.4 11.3 5.6 1.2 9.8 0.2 3.4 4 0 0 4 4 4 0 Homeodomain-like domain Stn1 PF10451.9 AAS54641.1 - 1.6e-96 322.1 0.0 2.1e-96 321.7 0.0 1.1 1 0 0 1 1 1 1 Telomere regulation protein Stn1 Stn1_C PF12659.7 AAS54641.1 - 7.5e-32 109.8 0.0 1.4e-31 109.0 0.0 1.4 1 0 0 1 1 1 1 Telomere capping C-terminal wHTH MCM6_C PF18263.1 AAS54641.1 - 0.17 12.1 0.0 0.38 11.0 0.0 1.6 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain Lipocalin_9 PF17186.4 AAS54641.1 - 0.2 12.0 0.0 0.39 11.0 0.0 1.5 1 0 0 1 1 1 0 Lipocalin-like domain Methyltransf_8 PF05148.15 AAS54642.1 - 1.5e-66 224.4 1.2 6.1e-65 219.1 0.5 2.3 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 AAS54642.1 - 1.2e-06 29.1 0.0 5.6e-06 26.9 0.0 2.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AAS54642.1 - 0.00033 21.3 0.2 0.0029 18.3 0.0 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS54642.1 - 0.0066 16.2 0.0 0.24 11.2 0.0 2.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AAS54642.1 - 0.035 14.1 1.4 0.75 9.8 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain Zip PF02535.22 AAS54642.1 - 0.78 8.9 3.7 1.2 8.3 3.1 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter DUF3959 PF13105.6 AAS54642.1 - 4.9 6.6 5.5 11 5.5 5.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Gti1_Pac2 PF09729.9 AAS54642.1 - 5.1 7.1 9.7 12 6.0 9.7 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family Presenilin PF01080.17 AAS54642.1 - 5.2 5.7 6.6 7.8 5.1 6.6 1.2 1 0 0 1 1 1 0 Presenilin DUF846 PF05832.12 AAS54643.1 - 7.7e-43 145.9 1.1 9.6e-43 145.6 1.1 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF846) Myelin_PLP PF01275.19 AAS54643.1 - 0.033 14.1 1.4 0.044 13.6 1.4 1.1 1 0 0 1 1 1 0 Myelin proteolipid protein (PLP or lipophilin) SSF PF00474.17 AAS54645.2 - 1e-05 24.6 32.3 9.4e-05 21.4 32.3 2.2 1 1 0 1 1 1 1 Sodium:solute symporter family CBFD_NFYB_HMF PF00808.23 AAS54646.1 - 6.8e-12 45.5 0.2 1.2e-11 44.7 0.2 1.5 1 1 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone SecE PF00584.20 AAS54647.1 - 3.4e-13 49.3 0.0 3.7e-13 49.2 0.0 1.0 1 0 0 1 1 1 1 SecE/Sec61-gamma subunits of protein translocation complex Nop52 PF05997.12 AAS54648.1 - 4.7e-69 232.5 0.0 5.4e-69 232.3 0.0 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 Slu7 PF11708.8 AAS54649.1 - 2.2e-11 44.0 1.6 1.2e-05 25.2 0.1 3.1 2 1 1 3 3 3 3 Pre-mRNA splicing Prp18-interacting factor DUF4118 PF13493.6 AAS54650.1 - 7.9 6.3 9.4 0.48 10.2 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) SPT2 PF08243.11 AAS54651.1 - 5.2e-27 94.6 29.2 5.2e-27 94.6 29.2 1.9 2 0 0 2 2 2 1 SPT2 chromatin protein DUF4770 PF15994.5 AAS54651.1 - 2.8 8.2 6.6 1.3 9.2 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Rad4 PF03835.15 AAS54652.2 - 6.7e-38 129.7 0.1 1.1e-37 129.0 0.1 1.3 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_3 PF10405.9 AAS54652.2 - 7.3e-25 87.2 0.2 2.3e-24 85.6 0.1 1.9 2 0 0 2 2 2 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 AAS54652.2 - 6.9e-15 54.6 0.0 1.5e-14 53.6 0.0 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Transglut_core PF01841.19 AAS54652.2 - 0.0014 19.0 0.0 0.0048 17.3 0.0 1.9 1 0 0 1 1 1 1 Transglutaminase-like superfamily DUF5464 PF17552.2 AAS54652.2 - 0.14 12.4 0.0 0.31 11.4 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5464) PBP1_TM PF14812.6 AAS54652.2 - 3.7 8.0 5.5 10 6.5 1.0 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CK_II_beta PF01214.18 AAS54653.1 - 1.3e-68 230.4 0.0 1.7e-68 230.0 0.0 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit HSCB_C PF07743.13 AAS54654.1 - 1.7e-19 70.0 1.6 4.1e-19 68.8 1.6 1.7 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 AAS54654.1 - 6.2e-05 23.1 0.0 0.00018 21.6 0.0 1.7 2 0 0 2 2 2 1 DnaJ domain PikAIV_N PF18605.1 AAS54654.1 - 0.089 12.4 7.4 0.62 9.7 0.8 2.5 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain ATE_C PF04377.15 AAS54655.1 - 1.1e-44 152.3 0.0 2.2e-44 151.4 0.0 1.5 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, C terminus ATE_N PF04376.13 AAS54655.1 - 2.3e-24 85.6 1.5 4.8e-24 84.6 1.5 1.6 1 0 0 1 1 1 1 Arginine-tRNA-protein transferase, N terminus Importin_rep_3 PF18806.1 AAS54656.1 - 0.042 13.9 0.1 0.41 10.7 0.0 2.7 2 0 0 2 2 2 0 Importin 13 repeat Urb2 PF10441.9 AAS54656.1 - 0.059 13.3 5.4 0.11 12.4 0.1 3.6 3 1 0 3 3 3 0 Urb2/Npa2 family Dicty_REP PF05086.12 AAS54656.1 - 0.15 10.0 0.1 0.22 9.4 0.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Aminotran_1_2 PF00155.21 AAS54657.1 - 9.7e-20 71.0 0.0 1.4e-19 70.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 AAS54657.1 - 0.015 14.6 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family WD40 PF00400.32 AAS54658.2 - 7.1e-28 96.3 18.5 1.6e-07 31.9 0.0 7.8 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54658.2 - 7.3e-16 58.3 0.3 0.015 15.6 0.0 6.3 3 1 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Hira PF07569.11 AAS54658.2 - 2.4e-09 37.3 0.1 1.1e-08 35.0 0.1 2.1 2 0 0 2 2 2 1 TUP1-like enhancer of split HIRA_B PF09453.10 AAS54658.2 - 7.9e-08 32.0 0.2 3e-07 30.1 0.0 2.0 2 0 0 2 2 2 1 HIRA B motif Ge1_WD40 PF16529.5 AAS54658.2 - 0.0031 16.5 0.2 7.7 5.4 0.0 3.9 3 1 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AAS54658.2 - 0.011 15.1 0.1 0.62 9.3 0.0 2.9 3 0 0 3 3 3 0 WD40-like domain PD40 PF07676.12 AAS54658.2 - 0.037 14.0 0.0 7.7 6.6 0.0 3.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat IKI3 PF04762.12 AAS54658.2 - 0.041 11.9 0.4 0.71 7.8 0.1 2.6 3 1 1 4 4 4 0 IKI3 family Aconitase PF00330.20 AAS54659.2 - 6.2e-158 526.6 0.1 7.5e-158 526.3 0.1 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AAS54659.2 - 3.7e-42 143.8 0.0 6.9e-42 142.9 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain SH3_1 PF00018.28 AAS54660.2 - 1.9e-33 113.8 5.9 8.2e-13 47.8 0.1 4.5 4 0 0 4 4 4 3 SH3 domain SHD1 PF03983.12 AAS54660.2 - 5.8e-33 112.5 0.1 1.2e-32 111.6 0.1 1.5 1 0 0 1 1 1 1 SLA1 homology domain 1, SHD1 SH3_9 PF14604.6 AAS54660.2 - 2.8e-30 103.9 8.1 6.8e-12 45.1 0.4 4.7 4 0 0 4 4 4 3 Variant SH3 domain SH3_2 PF07653.17 AAS54660.2 - 4.2e-23 80.8 0.9 9.4e-06 25.2 0.1 4.4 4 0 0 4 4 4 3 Variant SH3 domain SAM_4 PF18017.1 AAS54660.2 - 0.0022 17.9 0.0 0.0047 16.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3104 PF11302.8 AAS54660.2 - 0.038 13.7 0.1 0.1 12.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3104) SH3_16 PF18348.1 AAS54660.2 - 0.046 13.5 0.2 0.098 12.5 0.2 1.5 1 0 0 1 1 1 0 Bacterial dipeptidyl-peptidase Sh3 domain ParD_antitoxin PF03693.14 AAS54660.2 - 0.1 13.1 0.2 0.28 11.6 0.2 1.7 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Periviscerokin PF08259.11 AAS54660.2 - 0.18 12.1 9.2 0.78 10.2 0.3 5.2 5 0 0 5 5 5 0 Periviscerokinin family SH3_3 PF08239.11 AAS54660.2 - 0.27 11.5 0.7 0.97 9.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial SH3 domain DUF962 PF06127.11 AAS54661.2 - 3.2e-23 81.6 0.0 5.5e-23 80.9 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF962) zf-C2H2 PF00096.26 AAS54662.2 - 6.9e-09 35.7 15.6 0.00013 22.2 4.5 3.5 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS54662.2 - 6e-05 23.3 5.1 0.00024 21.4 1.3 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS54662.2 - 6.8e-05 23.4 11.1 0.032 15.1 0.8 3.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AAS54662.2 - 0.009 16.0 4.4 0.099 12.7 1.9 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-met PF12874.7 AAS54662.2 - 0.012 16.0 2.4 2 8.9 0.0 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AAS54662.2 - 0.033 14.5 0.6 14 6.1 0.6 2.8 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Rad9_Rad53_bind PF08605.10 AAS54663.1 - 1.1e-46 158.2 0.1 2.8e-46 156.9 0.1 1.7 1 0 0 1 1 1 1 Fungal Rad9-like Rad53-binding BRCT PF00533.26 AAS54663.1 - 3.4e-09 37.0 0.3 9.6e-09 35.5 0.0 2.0 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 AAS54663.1 - 0.00036 20.4 0.0 0.00084 19.2 0.0 1.6 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 AAS54663.1 - 0.0018 18.6 0.0 0.0066 16.8 0.0 2.0 1 1 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain Septin PF00735.18 AAS54665.1 - 5.6e-79 265.3 1.9 1.9e-78 263.6 1.9 1.7 1 1 0 1 1 1 1 Septin Dynamin_N PF00350.23 AAS54665.1 - 0.00068 19.7 0.0 0.0015 18.6 0.0 1.6 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 AAS54665.1 - 0.00089 19.3 0.0 0.002 18.2 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 AAS54665.1 - 0.0012 18.7 0.1 0.26 11.2 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AAS54665.1 - 0.0018 18.5 0.0 0.0043 17.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain Pox_A32 PF04665.12 AAS54665.1 - 0.0026 17.3 0.3 0.0055 16.2 0.0 1.6 2 0 0 2 2 2 1 Poxvirus A32 protein AAA_23 PF13476.6 AAS54665.1 - 0.0027 18.2 0.1 0.0069 16.9 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AAS54665.1 - 0.004 16.9 0.0 0.05 13.3 0.0 2.2 2 0 0 2 2 2 1 AAA domain T2SSE PF00437.20 AAS54665.1 - 0.0056 15.8 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 AAS54665.1 - 0.006 17.1 0.4 0.018 15.6 0.1 2.1 2 1 0 2 2 2 1 ABC transporter PduV-EutP PF10662.9 AAS54665.1 - 0.0084 15.9 0.2 0.16 11.7 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 AAS54665.1 - 0.01 15.2 0.0 0.019 14.3 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Microtub_bd PF16796.5 AAS54665.1 - 0.012 15.6 0.0 0.028 14.3 0.0 1.6 1 0 0 1 1 1 0 Microtubule binding G-alpha PF00503.20 AAS54665.1 - 0.012 14.7 1.5 0.072 12.2 0.0 2.6 1 1 1 3 3 3 0 G-protein alpha subunit Roc PF08477.13 AAS54665.1 - 0.016 15.5 0.0 0.065 13.5 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase cobW PF02492.19 AAS54665.1 - 0.039 13.5 0.2 0.13 11.9 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.12 AAS54665.1 - 0.041 13.8 0.1 0.1 12.5 0.0 1.6 2 0 0 2 2 1 0 NACHT domain IIGP PF05049.13 AAS54665.1 - 0.049 12.7 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) AAA_33 PF13671.6 AAS54665.1 - 0.053 13.7 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 AAS54665.1 - 0.054 13.0 0.2 5 6.6 0.0 2.4 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 AAS54665.1 - 0.081 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AAS54665.1 - 0.086 13.2 0.0 0.54 10.7 0.0 2.4 2 0 0 2 2 1 0 RNA helicase AAA_29 PF13555.6 AAS54665.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 AAS54665.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain PMR5N PF14416.6 AAS54666.2 - 0.091 13.1 0.1 0.22 11.9 0.1 1.6 1 0 0 1 1 1 0 PMR5 N terminal Domain F-box-like PF12937.7 AAS54667.2 - 1.6e-07 31.1 0.6 3.3e-07 30.1 0.6 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 AAS54667.2 - 5.1e-07 29.4 0.1 1.1e-06 28.4 0.1 1.6 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 AAS54667.2 - 0.00023 21.0 0.4 0.0004 20.2 0.4 1.4 1 0 0 1 1 1 1 F-box PRANC PF09372.10 AAS54667.2 - 0.075 13.4 0.2 0.075 13.4 0.2 2.6 3 1 0 3 3 3 0 PRANC domain PRKCSH-like PF12999.7 AAS54668.2 - 1.4e-46 158.5 1.1 1.4e-46 158.5 1.1 2.3 2 0 0 2 2 2 1 Glucosidase II beta subunit-like PRKCSH_1 PF13015.6 AAS54668.2 - 3.7e-21 75.4 0.0 7.3e-20 71.2 0.0 2.5 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 AAS54668.2 - 3.2e-07 31.3 0.1 9.5e-07 29.7 0.0 1.9 2 0 0 2 2 1 1 Glucosidase II beta subunit-like protein FliJ PF02050.16 AAS54668.2 - 0.0041 17.3 10.4 0.065 13.5 1.6 2.7 2 0 0 2 2 2 2 Flagellar FliJ protein Spc7 PF08317.11 AAS54668.2 - 0.0063 15.4 3.1 0.028 13.3 0.1 2.2 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF4600 PF15372.6 AAS54668.2 - 0.033 14.6 2.0 2.1 8.8 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DivIC PF04977.15 AAS54668.2 - 0.04 13.7 2.8 0.1 12.4 0.4 2.4 2 0 0 2 2 2 0 Septum formation initiator CENP-F_leu_zip PF10473.9 AAS54668.2 - 0.062 13.3 7.6 0.22 11.6 0.9 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FlaC_arch PF05377.11 AAS54668.2 - 0.071 13.5 3.5 0.54 10.7 0.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) WXG100 PF06013.12 AAS54668.2 - 0.12 12.6 2.5 28 5.0 0.5 3.4 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Ntox28 PF15605.6 AAS54668.2 - 0.17 12.1 1.1 1.4 9.2 0.2 2.5 2 0 0 2 2 2 0 Bacterial toxin 28 DUF2408 PF10303.9 AAS54668.2 - 0.17 12.4 4.6 1 9.9 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) MCPsignal PF00015.21 AAS54668.2 - 0.19 11.6 1.5 0.41 10.5 0.5 1.9 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RasGAP_C PF03836.15 AAS54668.2 - 0.25 11.5 4.6 0.34 11.0 0.8 2.4 2 0 0 2 2 2 0 RasGAP C-terminus BBS2_C PF14782.6 AAS54668.2 - 0.26 10.0 2.9 5.6 5.6 0.3 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal TPR_MLP1_2 PF07926.12 AAS54668.2 - 0.29 11.2 15.3 0.27 11.3 2.7 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 AAS54668.2 - 0.31 10.4 10.1 1.5 8.1 1.8 2.3 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 AAS54668.2 - 0.36 11.3 9.0 0.49 10.9 0.7 2.6 2 0 0 2 2 2 0 Apg6 coiled-coil region IFT57 PF10498.9 AAS54668.2 - 0.37 9.7 8.6 1.5 7.7 0.8 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Atg14 PF10186.9 AAS54668.2 - 0.46 9.5 4.3 2.3 7.2 0.2 2.2 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HAUS-augmin3 PF14932.6 AAS54668.2 - 0.48 9.9 8.3 0.11 12.0 0.6 2.2 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Syntaxin_2 PF14523.6 AAS54668.2 - 0.82 10.1 7.0 1 9.8 0.9 2.8 3 0 0 3 3 2 0 Syntaxin-like protein AAA_lid_9 PF17871.1 AAS54668.2 - 1.1 9.2 7.1 1 9.3 0.1 3.1 3 0 0 3 3 3 0 AAA lid domain SlyX PF04102.12 AAS54668.2 - 1.7 9.3 7.4 4.9 7.8 0.3 2.9 2 0 0 2 2 2 0 SlyX COG2 PF06148.11 AAS54668.2 - 1.7 8.7 6.0 5.9 7.0 0.3 2.9 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF16 PF01519.16 AAS54668.2 - 2.7 8.5 5.2 2.5 8.6 0.3 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 AAS54668.2 - 3.2 8.1 5.2 18 5.7 0.3 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin_2 PF01920.20 AAS54668.2 - 4 7.4 8.2 7.5 6.6 1.1 2.7 2 0 0 2 2 2 0 Prefoldin subunit DUF1664 PF07889.12 AAS54668.2 - 4.6 7.3 5.1 5.2 7.1 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 AAS54668.2 - 4.8 7.2 11.0 2.8 8.0 0.6 2.8 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Ax_dynein_light PF10211.9 AAS54668.2 - 4.9 7.1 9.0 1.1 9.2 1.8 2.3 2 0 0 2 2 2 0 Axonemal dynein light chain Mod_r PF07200.13 AAS54668.2 - 5.7 7.0 11.7 7.5 6.6 1.7 2.5 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ATP-synt_D PF01813.17 AAS54668.2 - 6.3 6.6 7.8 11 5.8 0.6 2.4 2 1 0 2 2 2 0 ATP synthase subunit D DHR10 PF18595.1 AAS54668.2 - 9.2 6.4 13.0 1.8 8.7 3.3 2.8 3 0 0 3 3 2 0 Designed helical repeat protein 10 domain CRF1 PF10380.9 AAS54669.1 - 1e-32 112.8 0.7 1e-32 112.8 0.7 2.9 4 0 0 4 4 4 1 Transcription factor CRF1 Utp13 PF08625.11 AAS54670.2 - 1.5e-47 161.1 0.3 2.4e-47 160.4 0.3 1.4 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 AAS54670.2 - 7.2e-46 153.2 15.1 1.1e-05 26.1 0.0 11.0 11 0 0 11 11 11 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54670.2 - 4.7e-23 81.3 2.4 0.0003 21.0 0.2 7.6 6 2 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 AAS54670.2 - 1e-08 34.6 3.0 0.12 11.3 0.0 6.9 2 2 3 7 7 7 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 AAS54670.2 - 1.3e-08 34.6 2.9 0.0039 16.6 0.0 4.7 3 2 2 5 5 5 2 WD40-like domain Nup160 PF11715.8 AAS54670.2 - 3.8e-07 29.2 5.3 0.99 8.0 0.0 5.8 3 2 2 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 AAS54670.2 - 0.00016 20.6 1.7 0.2 10.4 0.0 4.5 3 1 2 6 6 6 2 Nup133 N terminal like eIF2A PF08662.11 AAS54670.2 - 0.004 17.1 0.5 15 5.4 0.0 4.1 2 2 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 AAS54670.2 - 0.019 13.5 0.5 2.5 6.5 0.0 3.2 3 1 1 4 4 4 0 Cytochrome D1 heme domain Rsa3 PF14615.6 AAS54671.1 - 5.5e-15 54.7 0.0 9.4e-15 53.9 0.0 1.4 1 0 0 1 1 1 1 Ribosome-assembly protein 3 Hid1 PF12722.7 AAS54671.1 - 1.9 6.5 7.1 2.1 6.4 7.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Pap_E4 PF02711.14 AAS54671.1 - 2.9 8.9 9.3 2 9.4 7.3 1.7 1 1 1 2 2 2 0 E4 protein SPATA3 PF15662.5 AAS54671.1 - 4.6 7.8 11.4 6.6 7.3 11.4 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family DUF4692 PF15763.5 AAS54671.1 - 7.6 7.0 10.5 7.6 7.0 9.4 1.5 1 1 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) VIT1 PF01988.19 AAS54672.2 - 3.2e-61 206.9 0.1 3.8e-61 206.7 0.1 1.1 1 0 0 1 1 1 1 VIT family T3RM_EcoP15I_C PF18273.1 AAS54672.2 - 0.1 12.9 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 Type III R-M EcoP15I C-terminal domain Histone PF00125.24 AAS54673.1 - 8e-21 74.8 4.2 9.9e-21 74.5 4.2 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AAS54673.1 - 7.4e-06 26.2 0.1 7.4e-06 26.2 0.1 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 AAS54673.1 - 0.0019 18.6 0.0 0.0036 17.8 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CENP-W PF15510.6 AAS54673.1 - 0.026 14.7 0.0 0.04 14.1 0.0 1.3 1 0 0 1 1 1 0 CENP-W protein YscO-like PF16789.5 AAS54673.1 - 0.034 14.2 0.2 0.041 13.9 0.2 1.1 1 0 0 1 1 1 0 YscO-like protein Histone_H2A_C PF16211.5 AAS54674.1 - 7.5e-21 73.6 1.2 1.2e-20 72.9 1.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A Histone PF00125.24 AAS54674.1 - 5.9e-19 68.7 0.0 7.7e-19 68.3 0.0 1.2 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 AAS54674.1 - 1.7e-06 28.2 0.0 3.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone LcrG PF07216.12 AAS54674.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 LcrG protein zf-C2H2 PF00096.26 AAS54676.2 - 2.5e-12 46.5 6.6 1.9e-05 24.8 0.3 2.9 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 AAS54676.2 - 6.3e-10 39.0 7.6 1.8e-05 24.9 0.4 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 AAS54676.2 - 3.3e-09 36.8 6.2 0.001 19.7 0.3 3.0 2 0 0 2 2 2 2 C2H2-type zinc finger zf-met PF12874.7 AAS54676.2 - 2.6e-06 27.6 3.4 0.0028 18.0 0.1 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AAS54676.2 - 2.2e-05 24.6 1.0 0.27 11.6 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 AAS54676.2 - 0.0056 16.6 3.5 0.56 10.2 0.1 2.6 2 0 0 2 2 2 2 zinc-finger of a C2HC-type DUF2256 PF10013.9 AAS54676.2 - 0.015 15.4 1.7 0.16 12.1 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Di19 PF05605.12 AAS54676.2 - 0.015 15.5 2.3 0.18 12.1 2.2 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Zn-C2H2_12 PF18112.1 AAS54676.2 - 0.045 14.2 1.0 0.084 13.4 0.0 2.1 2 0 0 2 2 1 0 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_2 PF12756.7 AAS54676.2 - 0.11 12.8 1.1 16 5.9 0.0 2.6 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_6 PF13912.6 AAS54676.2 - 0.12 12.4 9.7 0.6 10.2 1.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_5 PF13909.6 AAS54676.2 - 0.16 11.7 12.0 5.3 6.9 7.7 3.1 2 1 0 2 2 2 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 AAS54676.2 - 0.41 10.4 4.3 13 5.6 0.1 2.9 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-AN1 PF01428.16 AAS54676.2 - 0.76 10.0 4.7 3.6 7.8 0.2 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger Zn-ribbon_8 PF09723.10 AAS54676.2 - 1.1 9.4 7.1 6.2 7.0 0.1 3.5 3 1 0 3 3 3 0 Zinc ribbon domain ADK PF00406.22 AAS54677.1 - 3.1e-59 199.4 0.0 3.8e-59 199.1 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 AAS54677.1 - 1.5e-21 77.3 0.0 2.7e-21 76.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 AAS54677.1 - 4.1e-16 58.7 0.0 8.4e-16 57.7 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 AAS54677.1 - 1.6e-05 25.1 0.0 4.5e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 AAS54677.1 - 5e-05 23.9 0.0 9.1e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AAS54677.1 - 0.025 14.3 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain SIR4_SID PF16991.5 AAS54678.2 - 2.3e-16 60.2 0.0 2.3e-16 60.2 0.0 2.2 3 0 0 3 3 3 1 Sir4 SID domain SIR4_SID PF16991.5 AAS54679.2 - 3e-14 53.4 0.1 3e-14 53.4 0.1 2.3 2 0 0 2 2 2 1 Sir4 SID domain DUF4407 PF14362.6 AAS54679.2 - 0.1 11.9 7.8 0.032 13.6 1.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 AAS54679.2 - 0.32 11.1 8.2 0.46 10.6 0.7 3.8 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF5082 PF16888.5 AAS54679.2 - 7.4 6.9 11.5 0.43 10.9 0.1 3.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) Spc42p PF11544.8 AAS54679.2 - 9.4 6.3 7.5 6.2 6.9 0.1 3.3 2 0 0 2 2 2 0 Spindle pole body component Spc42p CFIA_Pcf11 PF11526.8 AAS54680.1 - 3.8e-23 81.8 4.4 1.1e-22 80.3 4.4 1.9 1 0 0 1 1 1 1 Subunit of cleavage factor IA Pcf11 VHS PF00790.19 AAS54680.1 - 0.02 14.7 1.1 0.16 11.8 0.0 2.9 3 0 0 3 3 3 0 VHS domain CTD_bind PF04818.13 AAS54680.1 - 0.023 15.5 0.0 0.14 13.0 0.0 2.4 2 0 0 2 2 2 0 RNA polymerase II-binding domain. CBM39 PF15886.5 AAS54680.1 - 0.05 13.5 1.4 0.11 12.4 1.4 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 32) Mito_carr PF00153.27 AAS54681.1 - 9.9e-30 102.3 1.0 9e-15 54.4 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein Methyltransf_4 PF02390.17 AAS54682.1 - 4.3e-59 198.8 0.1 5.8e-59 198.4 0.1 1.2 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.14 AAS54682.1 - 1.2e-05 25.0 0.0 6.4e-05 22.6 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AAS54682.1 - 6.6e-05 23.5 0.0 0.00024 21.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AAS54682.1 - 0.0001 22.2 0.0 0.00019 21.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AAS54682.1 - 0.0068 17.1 0.1 0.036 14.8 0.0 2.2 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_32 PF13679.6 AAS54682.1 - 0.027 14.4 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 AAS54682.1 - 0.037 14.7 0.0 0.28 11.9 0.0 2.5 2 1 0 2 2 2 0 Methyltransferase domain CMAS PF02353.20 AAS54682.1 - 0.056 12.7 0.0 0.093 12.0 0.0 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 AAS54682.1 - 0.086 12.2 0.0 0.22 10.8 0.0 1.7 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Ribosomal_L10 PF00466.20 AAS54683.1 - 4.3e-10 39.6 0.0 7.4e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L10 NOG1_N PF17835.1 AAS54684.1 - 1.6e-50 171.2 0.1 1.6e-50 171.2 0.1 2.8 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 AAS54684.1 - 4.8e-27 93.7 0.8 1.4e-26 92.3 0.8 1.9 1 0 0 1 1 1 1 NOGCT (NUC087) domain NOG1 PF06858.14 AAS54684.1 - 5.2e-25 87.0 1.8 7.2e-25 86.5 0.2 2.1 2 0 0 2 2 2 1 Nucleolar GTP-binding protein 1 (NOG1) MMR_HSR1 PF01926.23 AAS54684.1 - 2e-16 60.1 0.0 1.1e-15 57.7 0.0 2.2 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AAS54684.1 - 2.3e-08 33.7 0.0 5.1e-08 32.6 0.0 1.6 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 AAS54684.1 - 0.00068 19.1 0.2 0.0013 18.1 0.2 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 AAS54684.1 - 0.0017 18.3 0.1 1.2 9.1 0.1 3.1 3 0 0 3 3 3 2 RsgA GTPase Dynamin_N PF00350.23 AAS54684.1 - 0.016 15.3 0.0 4.9 7.2 0.0 3.1 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 AAS54684.1 - 0.044 14.2 0.0 0.14 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Myb_DNA-bind_4 PF13837.6 AAS54684.1 - 0.087 13.2 4.9 0.071 13.5 1.2 2.5 1 1 0 2 2 2 0 Myb/SANT-like DNA-binding domain AAA_23 PF13476.6 AAS54684.1 - 1.3 9.5 5.4 5.5 7.4 4.6 2.5 1 1 0 1 1 1 0 AAA domain MFS_1 PF07690.16 AAS54685.1 - 2.5e-44 151.6 32.0 3.9e-44 151.0 32.0 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 AAS54685.1 - 8.7e-18 64.4 23.0 2.2e-16 59.8 1.0 3.0 2 1 0 2 2 2 2 Sugar (and other) transporter OATP PF03137.20 AAS54685.1 - 0.0054 15.1 0.3 0.0054 15.1 0.3 3.3 2 2 1 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family Pyr_redox_2 PF07992.14 AAS54686.1 - 4.4e-66 223.1 1.8 6.5e-66 222.6 1.8 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AAS54686.1 - 1.3e-33 115.6 0.7 3.8e-33 114.0 0.2 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AAS54686.1 - 2.4e-19 69.7 5.8 3.6e-19 69.1 0.4 2.8 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AAS54686.1 - 7.7e-12 45.1 6.1 3.8e-11 42.8 6.1 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 AAS54686.1 - 3.7e-06 26.6 0.2 1.2e-05 24.9 0.1 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AAS54686.1 - 5e-06 25.5 3.2 0.14 10.9 0.1 3.1 2 1 0 3 3 3 3 HI0933-like protein K_oxygenase PF13434.6 AAS54686.1 - 3.7e-05 23.0 0.0 6.5e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 AAS54686.1 - 0.00025 20.2 0.0 0.00047 19.3 0.0 1.5 1 0 0 1 1 1 1 Glucose inhibited division protein A AlaDh_PNT_C PF01262.21 AAS54686.1 - 0.015 14.6 0.6 2.3 7.4 0.4 2.4 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 AAS54686.1 - 0.16 12.4 0.1 12 6.4 0.0 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AAS54686.1 - 0.38 10.1 1.6 6.4 6.1 0.0 2.8 3 0 0 3 3 3 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_2 PF00890.24 AAS54686.1 - 0.55 9.2 7.2 0.23 10.5 2.1 2.6 3 0 0 3 3 3 0 FAD binding domain DAO PF01266.24 AAS54686.1 - 1.8 8.1 5.8 16 4.9 5.7 2.4 1 1 0 1 1 1 0 FAD dependent oxidoreductase Ribosomal_S6e PF01092.19 AAS54687.1 - 1.5e-56 189.7 0.3 3.7e-56 188.5 0.3 1.6 1 0 0 1 1 1 1 Ribosomal protein S6e Caps_synth_GfcC PF06251.11 AAS54687.1 - 0.16 11.5 1.4 0.23 11.0 1.4 1.2 1 0 0 1 1 1 0 Capsule biosynthesis GfcC SRF-TF PF00319.18 AAS54688.1 - 2.8e-20 71.5 0.1 5.4e-20 70.6 0.1 1.5 1 0 0 1 1 1 1 SRF-type transcription factor (DNA-binding and dimerisation domain) Ceramidase PF05875.12 AAS54689.2 - 5.3e-84 281.7 8.0 6e-84 281.6 8.0 1.0 1 0 0 1 1 1 1 Ceramidase Beta_elim_lyase PF01212.21 AAS54690.2 - 6.5e-61 206.2 0.1 7.6e-61 206.0 0.1 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AAS54690.2 - 0.0036 16.5 0.0 0.0048 16.1 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Radical_SAM_C PF16199.5 AAS54691.1 - 9.9e-33 112.0 0.0 2.4e-32 110.8 0.0 1.7 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AAS54691.1 - 6.3e-19 69.0 0.8 2.4e-18 67.0 0.1 2.2 3 0 0 3 3 3 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AAS54691.1 - 1.8e-10 41.0 0.2 3.4e-10 40.2 0.2 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AAS54691.1 - 2.3e-06 27.5 0.0 5.3e-06 26.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AAS54691.1 - 0.022 15.2 0.1 0.047 14.1 0.1 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Sec16_C PF12931.7 AAS54692.1 - 2.3e-70 237.6 0.0 3.3e-70 237.1 0.0 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Sec16_N PF12935.7 AAS54692.1 - 4.7e-63 213.5 29.2 4.7e-63 213.5 29.2 4.5 4 1 1 5 5 5 1 Vesicle coat trafficking protein Sec16 N-terminus Sec16 PF12932.7 AAS54692.1 - 0.00053 20.6 0.0 0.00053 20.6 0.0 2.5 2 0 0 2 2 2 1 Vesicle coat trafficking protein Sec16 mid-region Nup96 PF12110.8 AAS54692.1 - 0.033 13.3 0.1 0.077 12.1 0.1 1.6 1 0 0 1 1 1 0 Nuclear protein 96 MBA1 PF07961.11 AAS54693.1 - 3.9e-107 356.6 0.0 4.5e-107 356.5 0.0 1.0 1 0 0 1 1 1 1 MBA1-like protein Tim44 PF04280.15 AAS54693.1 - 0.14 12.3 0.0 0.19 11.8 0.0 1.3 1 0 0 1 1 1 0 Tim44-like domain BRO1 PF03097.18 AAS54694.2 - 2.1e-88 296.8 3.9 3.7e-88 295.9 0.9 2.4 2 0 0 2 2 2 1 BRO1-like domain ALIX_LYPXL_bnd PF13949.6 AAS54694.2 - 1.9e-28 99.6 10.4 1.9e-28 99.6 10.4 2.1 1 1 1 2 2 2 1 ALIX V-shaped domain binding to HIV MetJ PF01340.20 AAS54694.2 - 0.039 13.9 0.2 0.54 10.3 0.1 2.7 2 1 0 2 2 2 0 Met Apo-repressor, MetJ tRNA_int_end_N2 PF12928.7 AAS54695.1 - 4.9e-17 61.9 0.1 1.1e-16 60.7 0.1 1.6 1 0 0 1 1 1 1 tRNA-splicing endonuclease subunit sen54 N-term tRNA-synt_2 PF00152.20 AAS54696.1 - 1.7e-96 323.0 0.0 2.1e-96 322.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AAS54696.1 - 1.3e-05 25.0 0.1 2.6e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2b PF00587.25 AAS54696.1 - 0.12 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) Mis12 PF05859.12 AAS54696.1 - 0.15 12.2 0.1 0.38 10.8 0.1 1.7 1 0 0 1 1 1 0 Mis12 protein WD40 PF00400.32 AAS54697.1 - 4.1e-27 93.9 14.5 3.9e-05 24.3 0.1 7.1 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54697.1 - 2.1e-17 63.2 0.2 2.5e-05 24.5 0.0 5.6 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 AAS54697.1 - 0.00012 22.0 0.0 0.0099 15.8 0.0 3.1 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 AAS54697.1 - 0.00042 19.1 0.4 0.45 9.1 0.1 3.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 AAS54697.1 - 0.0041 16.1 0.5 19 4.1 0.0 4.3 2 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 AAS54697.1 - 0.016 14.3 0.0 0.054 12.5 0.0 1.7 1 1 1 2 2 2 0 Coatomer WD associated region Cytochrom_D1 PF02239.16 AAS54697.1 - 0.2 10.2 0.4 2.8 6.4 0.1 2.7 2 1 1 3 3 3 0 Cytochrome D1 heme domain UMP1 PF05348.11 AAS54698.1 - 8.9e-32 109.8 0.0 1.1e-31 109.5 0.0 1.1 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 GYF PF02213.16 AAS54699.2 - 8.5e-12 44.6 0.2 2.3e-11 43.2 0.2 1.7 1 0 0 1 1 1 1 GYF domain Sec66 PF09802.9 AAS54700.1 - 9.6e-71 237.1 2.6 1.1e-70 236.9 2.6 1.0 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 NPL4 PF05021.15 AAS54701.1 - 9.8e-135 448.8 0.0 1.3e-134 448.4 0.0 1.1 1 0 0 1 1 1 1 NPL4 family zf-NPL4 PF05020.15 AAS54701.1 - 3.4e-64 215.4 0.5 5e-64 214.8 0.5 1.3 1 0 0 1 1 1 1 NPL4 family, putative zinc binding region UN_NPL4 PF11543.8 AAS54701.1 - 2.3e-06 28.0 0.0 5.4e-06 26.8 0.0 1.6 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 HSP70 PF00012.20 AAS54702.1 - 3.9e-185 616.5 4.7 3.9e-185 616.5 4.7 1.9 1 1 1 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 AAS54702.1 - 9.8e-09 34.5 0.1 1.8e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 MreB/Mbl protein FtsA PF14450.6 AAS54702.1 - 8.3e-05 23.0 1.4 0.0016 18.8 0.1 3.2 3 0 0 3 3 3 1 Cell division protein FtsA Ketoacyl-synt_C PF02801.22 AAS54702.1 - 0.047 13.7 0.5 0.22 11.5 0.0 2.3 2 0 0 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain Trans_reg_C PF00486.28 AAS54702.1 - 0.12 12.5 0.1 1 9.5 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal NLE PF08154.12 AAS54702.1 - 0.12 12.9 0.3 0.64 10.6 0.1 2.4 2 0 0 2 2 2 0 NLE (NUC135) domain Sulfate_transp PF00916.20 AAS54703.1 - 1.1e-76 258.0 12.7 1.6e-76 257.5 12.7 1.2 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 AAS54703.1 - 1e-14 54.1 0.0 1.8e-14 53.4 0.0 1.3 1 0 0 1 1 1 1 STAS domain CHIPS PF11434.8 AAS54703.1 - 0.012 15.4 0.1 0.037 13.9 0.1 1.7 1 0 0 1 1 1 0 Chemotaxis-inhibiting protein CHIPS UPF0242 PF06785.11 AAS54703.1 - 0.014 15.5 2.9 0.089 12.9 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus SCAB-ABD PF16711.5 AAS54703.1 - 0.11 12.4 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Actin-binding domain of plant-specific actin-binding protein Oxidored-like PF09791.9 AAS54704.1 - 6.6e-25 86.5 1.4 1.2e-24 85.7 1.4 1.4 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal DUF4851 PF16143.5 AAS54704.1 - 0.03 13.8 0.3 7.4 6.0 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4851) Pex24p PF06398.11 AAS54705.1 - 8.7e-37 127.0 9.8 1.1e-36 126.6 9.8 1.1 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Rpp20 PF12328.8 AAS54706.1 - 8.6e-18 64.6 0.1 6.4e-16 58.6 0.1 2.1 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Alba PF01918.21 AAS54706.1 - 9.8e-09 34.9 0.0 1.3e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Alba Ureidogly_lyase PF04115.12 AAS54708.1 - 1.5e-46 158.5 0.0 1.8e-46 158.3 0.0 1.0 1 0 0 1 1 1 1 Ureidoglycolate lyase PDH PF02153.17 AAS54709.2 - 1.6e-09 37.2 0.0 6.6e-09 35.1 0.0 1.8 2 0 0 2 2 2 1 Prephenate dehydrogenase F420_oxidored PF03807.17 AAS54709.2 - 2.8e-07 31.0 0.0 5.5e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AAS54709.2 - 4.6e-07 30.1 0.0 8.3e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 AAS54709.2 - 6.1e-06 25.7 0.0 1.1e-05 24.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 AAS54709.2 - 7.2e-06 25.7 0.1 2.3e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 3HCDH_N PF02737.18 AAS54709.2 - 3.2e-05 23.9 0.0 4.9e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AAS54709.2 - 0.00025 21.1 0.0 0.0005 20.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 AAS54709.2 - 0.014 15.6 0.0 0.037 14.3 0.0 1.7 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 AAS54709.2 - 0.048 13.2 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Arf PF00025.21 AAS54711.2 - 1.3e-74 249.4 0.0 1.5e-74 249.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 AAS54711.2 - 3.2e-15 56.4 0.0 4.2e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 AAS54711.2 - 3.1e-11 43.1 0.0 3.8e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 AAS54711.2 - 4.5e-11 42.6 0.0 5.2e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 AAS54711.2 - 5.5e-10 39.0 0.0 6.9e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 AAS54711.2 - 2.2e-09 37.0 0.2 1.4e-05 24.4 0.0 2.4 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 AAS54711.2 - 0.00024 21.1 0.0 0.00048 20.2 0.0 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS54711.2 - 0.00045 19.8 0.1 0.0042 16.7 0.0 2.0 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MeaB PF03308.16 AAS54711.2 - 0.00049 19.2 0.3 0.025 13.6 0.1 2.7 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 AAS54711.2 - 0.0038 17.7 0.2 0.011 16.2 0.2 1.7 1 1 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 AAS54711.2 - 0.044 14.3 0.1 0.064 13.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 AAS54711.2 - 0.044 13.7 0.2 7.6 6.4 0.1 2.1 2 0 0 2 2 2 0 NACHT domain cobW PF02492.19 AAS54711.2 - 0.062 12.9 0.5 8.9 5.9 0.2 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RsgA_GTPase PF03193.16 AAS54711.2 - 0.077 12.9 0.0 8 6.3 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase SRP54 PF00448.22 AAS54711.2 - 0.13 11.9 0.2 0.64 9.6 0.1 2.0 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain ABC1 PF03109.16 AAS54712.2 - 1.1e-18 67.6 0.0 2e-18 66.7 0.0 1.5 1 0 0 1 1 1 1 ABC1 family dDENN PF03455.19 AAS54712.2 - 0.046 13.7 0.2 0.21 11.6 0.2 2.2 2 1 0 2 2 2 0 dDENN domain GDPD PF03009.17 AAS54713.2 - 1.3e-76 257.8 0.0 2.3e-76 257.0 0.0 1.4 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family Ank_2 PF12796.7 AAS54713.2 - 6.5e-28 97.2 0.8 9.8e-13 48.5 0.1 4.2 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) SPX PF03105.19 AAS54713.2 - 9e-18 65.3 24.4 2.3e-11 44.3 0.6 4.6 3 2 1 4 4 4 3 SPX domain Ank_5 PF13857.6 AAS54713.2 - 1e-15 57.5 0.1 0.00016 21.9 0.0 5.3 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 AAS54713.2 - 7.1e-15 53.6 1.2 2.4 9.0 0.0 7.3 6 0 0 6 6 6 6 Ankyrin repeat Ank_4 PF13637.6 AAS54713.2 - 3.5e-14 53.0 0.4 7.8e-06 26.3 0.0 5.0 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 AAS54713.2 - 9.1e-10 38.5 2.0 0.024 15.1 0.0 6.0 6 0 0 6 6 6 3 Ankyrin repeat Arginase PF00491.21 AAS54715.1 - 1.3e-74 251.2 0.3 1.9e-74 250.7 0.0 1.3 2 0 0 2 2 2 1 Arginase family PEX11 PF05648.14 AAS54716.2 - 2.9e-07 30.2 1.2 0.0037 16.7 0.1 2.8 2 1 0 2 2 2 2 Peroxisomal biogenesis factor 11 (PEX11) 2-Hacid_dh_C PF02826.19 AAS54717.1 - 2.3e-38 131.3 0.0 4.7e-38 130.3 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AAS54717.1 - 0.0091 15.7 0.0 0.015 14.9 0.0 1.6 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ApbA PF02558.16 AAS54717.1 - 0.24 11.1 0.8 0.49 10.0 0.8 1.7 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA TFIIA PF03153.13 AAS54718.2 - 6.5e-50 171.3 13.5 2.9e-29 103.3 7.2 2.0 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit Fungal_TACC PF12709.7 AAS54719.2 - 1.4e-30 105.6 15.2 1.4e-30 105.6 15.2 7.4 3 2 5 8 8 8 1 Fungal Transforming acidic coiled-coil (TACC) proteins CEP63 PF17045.5 AAS54719.2 - 0.00028 20.9 41.2 0.00028 20.9 41.2 4.4 2 1 2 4 4 4 2 Centrosomal protein of 63 kDa ATG16 PF08614.11 AAS54719.2 - 0.0011 19.3 26.6 0.0011 19.3 26.6 5.1 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) Fez1 PF06818.15 AAS54719.2 - 0.0035 17.8 19.7 0.0035 17.8 19.7 5.3 1 1 3 4 4 4 2 Fez1 TPR_MLP1_2 PF07926.12 AAS54719.2 - 0.012 15.6 23.2 0.012 15.6 23.2 7.1 2 1 5 7 7 7 0 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 AAS54719.2 - 0.4 10.1 84.5 0.014 14.9 23.7 4.7 2 1 2 4 4 4 0 Golgin subfamily A member 5 AAA_13 PF13166.6 AAS54719.2 - 1.4 7.4 63.6 0.026 13.2 20.3 4.6 2 1 3 5 5 5 0 AAA domain Hemagglutinin PF00509.18 AAS54719.2 - 9.9 4.4 7.6 3.4 5.9 0.7 2.4 2 0 0 2 2 2 0 Haemagglutinin RhoGAP PF00620.27 AAS54720.2 - 9.5e-34 116.4 0.0 1.9e-33 115.4 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PH PF00169.29 AAS54720.2 - 6.9e-08 32.9 0.6 2.6e-07 31.1 0.1 2.3 2 0 0 2 2 2 1 PH domain DUF1708 PF08101.11 AAS54720.2 - 0.00028 20.2 0.0 0.00051 19.3 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1708) PX PF00787.24 AAS54720.2 - 0.00034 20.6 0.1 0.00082 19.3 0.1 1.7 1 0 0 1 1 1 1 PX domain Csm1_N PF18504.1 AAS54720.2 - 0.0039 17.5 0.3 0.034 14.5 0.7 2.2 2 0 0 2 2 2 1 Csm1 N-terminal domain COMP PF11598.8 AAS54720.2 - 0.15 12.6 2.1 0.31 11.5 2.1 1.5 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein LIAS_N PF16881.5 AAS54721.1 - 3.9e-23 81.9 0.7 9.3e-23 80.7 0.3 1.8 2 0 0 2 2 2 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 AAS54721.1 - 1.2e-15 58.3 0.0 5.9e-15 56.0 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Phyto-Amp PF15438.6 AAS54721.1 - 0.02 14.7 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 Antigenic membrane protein of phytoplasma BolA PF01722.18 AAS54722.1 - 1.2e-15 57.5 0.0 1.4e-15 57.3 0.0 1.2 1 0 0 1 1 1 1 BolA-like protein NIF3 PF01784.18 AAS54723.1 - 1.2e-66 224.9 0.1 1.4e-66 224.6 0.1 1.0 1 0 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) DUF5364 PF17322.2 AAS54724.1 - 3.9e-53 180.5 11.3 4.4e-53 180.4 11.3 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5364) SAP25 PF15476.6 AAS54724.1 - 0.062 13.0 0.1 0.071 12.8 0.1 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP25 tRNA-synt_His PF13393.6 AAS54724.1 - 0.067 12.5 1.3 0.38 10.0 0.3 2.1 1 1 1 2 2 2 0 Histidyl-tRNA synthetase DUF5031 PF16434.5 AAS54724.1 - 0.1 11.7 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5031) MFS_1 PF07690.16 AAS54725.2 - 9.1e-18 64.3 21.7 1.1e-17 64.0 21.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 AAS54725.2 - 0.00061 18.8 0.3 0.00061 18.8 0.3 2.0 2 0 0 2 2 2 1 MFS_1 like family COX2-transmemb PF09125.10 AAS54725.2 - 7.2 6.5 6.2 3.8 7.4 0.6 3.1 3 1 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane SMC_N PF02463.19 AAS54726.1 - 2.6e-71 239.6 5.7 3.6e-39 134.5 0.0 4.5 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 AAS54726.1 - 6e-18 65.3 0.8 1.9e-17 63.7 0.2 2.1 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_23 PF13476.6 AAS54726.1 - 1.8e-14 54.8 0.6 1.8e-14 54.8 0.6 6.8 2 2 2 5 5 5 1 AAA domain AAA_21 PF13304.6 AAS54726.1 - 1.2e-06 28.5 19.3 0.00034 20.5 0.3 3.7 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AAS54726.1 - 2.4e-05 24.2 13.4 2.4e-05 24.2 13.4 4.3 2 2 1 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 AAS54726.1 - 0.00055 19.6 0.1 0.0018 18.0 0.1 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain GAS PF13851.6 AAS54726.1 - 0.0059 16.0 11.7 0.0059 16.0 11.7 7.6 2 2 3 7 7 7 4 Growth-arrest specific micro-tubule binding YvbH_ext PF11724.8 AAS54726.1 - 0.039 14.3 0.7 0.8 10.1 0.0 3.4 2 0 0 2 2 2 0 YvbH-like oligomerisation region DUF1514 PF07438.11 AAS54726.1 - 0.76 9.7 2.8 2.7 7.9 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) ABC_tran PF00005.27 AAS54726.1 - 1.1 9.8 0.0 1.1 9.8 0.0 5.9 3 2 0 3 3 3 0 ABC transporter FAD_binding_1 PF00667.20 AAS54727.1 - 3e-69 233.0 0.0 1.2e-68 231.1 0.0 1.9 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 AAS54727.1 - 1.4e-06 28.9 0.0 3.6e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AAS54727.1 - 0.074 13.4 0.0 0.78 10.1 0.0 2.2 2 0 0 2 2 2 0 Oxidoreductase FAD-binding domain Peptidase_M56 PF05569.11 AAS54727.1 - 0.17 11.1 0.0 15 4.7 0.0 2.5 3 0 0 3 3 3 0 BlaR1 peptidase M56 LMSTEN PF07988.12 AAS54728.2 - 0.0076 15.7 0.9 0.018 14.5 0.9 1.6 1 0 0 1 1 1 1 LMSTEN motif DUF4898 PF16239.5 AAS54728.2 - 0.023 14.7 0.5 0.069 13.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4898) HEAT PF02985.22 AAS54728.2 - 0.055 13.7 0.1 0.39 11.1 0.0 2.6 2 0 0 2 2 2 0 HEAT repeat DUF5071 PF16804.5 AAS54728.2 - 0.26 11.5 3.5 0.33 11.2 0.4 2.8 2 2 0 2 2 2 0 Domain of unknown function (DUF5071) BAG PF02179.16 AAS54729.1 - 8.1e-13 48.6 3.5 1.3e-12 47.9 3.5 1.3 1 0 0 1 1 1 1 BAG domain Asp PF00026.23 AAS54730.2 - 2.3e-61 208.0 0.0 2.7e-61 207.7 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AAS54730.2 - 5.6e-11 43.0 0.0 1.2e-10 42.0 0.0 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Lum_binding PF00677.17 AAS54731.1 - 4.1e-43 145.3 0.1 1.5e-20 72.9 0.1 2.2 2 0 0 2 2 2 2 Lumazine binding domain ANAPC4_WD40 PF12894.7 AAS54732.1 - 1.1e-08 35.3 0.4 0.0089 16.3 0.0 4.9 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 AAS54732.1 - 1.1e-07 32.4 5.6 0.86 10.6 0.1 6.9 8 0 0 8 8 8 2 WD domain, G-beta repeat PQQ PF01011.21 AAS54732.1 - 0.019 14.8 0.9 2.2 8.3 0.0 4.0 6 0 0 6 6 6 0 PQQ enzyme repeat Cut8 PF08559.10 AAS54733.2 - 1.2e-61 208.4 1.6 1.4e-61 208.2 1.6 1.0 1 0 0 1 1 1 1 Cut8, nuclear proteasome tether protein Pkr1 PF08636.10 AAS54735.1 - 0.013 15.6 3.3 0.022 14.9 3.3 1.3 1 0 0 1 1 1 0 ER protein Pkr1 Sedlin_N PF04628.13 AAS54736.1 - 1.3e-54 183.9 0.0 1.5e-54 183.7 0.0 1.0 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region Sybindin PF04099.12 AAS54736.1 - 6.6e-06 26.1 0.2 1.2e-05 25.3 0.0 1.5 2 0 0 2 2 2 1 Sybindin-like family MIS13 PF08202.11 AAS54737.1 - 1.2e-61 208.6 3.5 1.9e-61 208.0 3.5 1.1 1 0 0 1 1 1 1 Mis12-Mtw1 protein family DUF1192 PF06698.11 AAS54737.1 - 0.61 10.2 3.2 1.6 8.8 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Med22 PF06179.12 AAS54738.1 - 2.3e-21 76.0 0.1 2.9e-21 75.7 0.1 1.1 1 0 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Herpes_UL46 PF03387.14 AAS54738.1 - 0.069 11.9 0.0 0.094 11.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL46 protein DUF4908 PF16252.5 AAS54738.1 - 0.14 11.7 0.7 0.26 10.8 0.6 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4908) dUTPase PF00692.19 AAS54739.1 - 2.2e-43 147.0 0.0 2.6e-43 146.8 0.0 1.0 1 0 0 1 1 1 1 dUTPase Acetyltransf_9 PF13527.7 AAS54740.2 - 0.00047 20.2 1.4 0.0027 17.8 0.2 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AAS54740.2 - 0.00062 20.1 0.0 0.0012 19.2 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AAS54740.2 - 0.027 14.4 0.0 0.063 13.3 0.0 1.6 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_1 PF00583.25 AAS54740.2 - 0.15 12.3 0.0 0.48 10.7 0.0 1.9 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Peptidase_M16 PF00675.20 AAS54741.2 - 4.7e-32 111.0 0.4 1.3e-31 109.6 0.1 1.9 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 AAS54741.2 - 6.7e-18 65.0 0.0 1.5e-17 63.8 0.0 1.7 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 AAS54741.2 - 6e-12 45.9 0.4 8.8e-06 25.9 0.0 3.8 4 0 0 4 4 4 2 Peptidase M16 inactive domain Rrp15p PF07890.12 AAS54742.1 - 8.3e-32 110.3 14.7 8.3e-32 110.3 14.7 2.2 2 1 0 2 2 2 1 Rrp15p Ndc1_Nup PF09531.10 AAS54742.1 - 1.7 7.2 8.8 2 7.0 8.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4711 PF15829.5 AAS54742.1 - 5.1 7.0 8.6 0.21 11.5 1.9 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4711) Kinesin PF00225.23 AAS54743.1 - 1.1e-102 343.4 2.2 1.1e-102 343.4 2.2 1.7 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 AAS54743.1 - 2.6e-55 186.4 0.1 2.6e-55 186.4 0.1 2.6 3 0 0 3 3 3 1 Microtubule binding STPPase_N PF16891.5 AAS54743.1 - 0.0066 16.9 0.8 0.056 13.9 0.7 2.7 3 0 0 3 3 3 1 Serine-threonine protein phosphatase N-terminal domain PhoH PF02562.16 AAS54743.1 - 0.013 15.0 0.8 0.11 12.0 0.1 2.7 2 1 0 2 2 2 0 PhoH-like protein DUF4094 PF13334.6 AAS54743.1 - 0.025 15.0 0.6 0.025 15.0 0.6 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Mg_chelatase_C PF13335.6 AAS54743.1 - 2.3 8.9 6.1 1.9 9.2 0.5 3.3 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI C-terminal Acyltransferase PF01553.21 AAS54744.1 - 2e-15 56.6 0.0 3.4e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase DAGK_cat PF00781.24 AAS54746.1 - 4.5e-25 87.7 0.0 7.3e-25 87.0 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Ras PF00071.22 AAS54747.1 - 4.5e-55 185.7 0.2 5.3e-55 185.4 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS54747.1 - 2.9e-37 127.5 0.1 4.1e-37 127.1 0.1 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS54747.1 - 6.1e-15 55.1 0.4 7.6e-15 54.8 0.4 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 AAS54747.1 - 1.1e-05 24.9 0.1 1.4e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 AAS54747.1 - 1.3e-05 25.2 0.0 0.026 14.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase MMR_HSR1 PF01926.23 AAS54747.1 - 1.6e-05 25.0 0.0 2.5e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 AAS54747.1 - 0.00011 21.8 0.1 0.0012 18.4 0.1 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 AAS54747.1 - 0.00018 21.0 0.0 0.00024 20.6 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 AAS54747.1 - 0.0052 16.3 0.0 0.0082 15.7 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 AAS54747.1 - 0.0067 16.4 0.4 0.0084 16.0 0.4 1.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 AAS54747.1 - 0.015 15.6 0.0 0.024 14.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.6 AAS54747.1 - 0.018 14.8 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 AAS54747.1 - 0.03 14.1 0.2 0.047 13.4 0.2 1.7 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.11 AAS54747.1 - 0.031 13.1 0.1 0.043 12.7 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_16 PF13191.6 AAS54747.1 - 0.037 14.4 0.0 0.063 13.7 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 AAS54747.1 - 0.09 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain ResIII PF04851.15 AAS54747.1 - 0.11 12.5 0.1 0.15 12.1 0.1 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit TMA7 PF09072.10 AAS54748.1 - 1.8e-24 86.3 16.9 1.9e-24 86.2 16.9 1.0 1 0 0 1 1 1 1 Translation machinery associated TMA7 tRNA-synt_1c PF00749.21 AAS54749.1 - 2.8e-116 387.8 0.0 4.2e-116 387.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA_synt_1c_R1 PF04558.15 AAS54749.1 - 3.8e-51 173.3 1.9 6.3e-51 172.6 1.9 1.4 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA-synt_1c_C PF03950.18 AAS54749.1 - 8e-33 113.7 0.0 7.9e-32 110.5 0.0 2.3 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R2 PF04557.15 AAS54749.1 - 6.6e-14 52.6 3.2 1.6e-13 51.4 3.2 1.7 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Red1 PF07964.11 AAS54750.2 - 4.7e-254 845.2 0.7 5.4e-254 845.0 0.7 1.0 1 0 0 1 1 1 1 Rec10 / Red1 Ribosomal_S28e PF01200.18 AAS54751.1 - 1.6e-32 111.2 2.0 1.8e-32 111.1 2.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e S_layer_C PF05124.12 AAS54751.1 - 0.11 12.5 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 S-layer like family, C-terminal region PIN_4 PF13638.6 AAS54752.1 - 2e-31 109.0 0.1 6.5e-31 107.3 0.1 1.9 1 0 0 1 1 1 1 PIN domain PIN_9 PF18477.1 AAS54752.1 - 1e-05 25.8 0.1 0.0043 17.4 0.0 2.6 2 0 0 2 2 2 2 PIN like domain XLF PF09302.11 AAS54753.1 - 0.0021 18.3 0.1 0.0046 17.1 0.1 1.6 1 1 0 1 1 1 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component Tospo_nucleocap PF01533.16 AAS54753.1 - 0.041 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 Tospovirus nucleocapsid protein DinB_2 PF12867.7 AAS54753.1 - 0.066 13.7 0.1 0.3 11.6 0.1 2.0 2 0 0 2 2 2 0 DinB superfamily DrrA_P4M PF14860.6 AAS54753.1 - 0.082 12.8 0.6 2 8.3 0.1 2.2 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain RHD3 PF05879.12 AAS54754.1 - 1.6e-229 763.9 10.7 2e-229 763.6 10.7 1.1 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 AAS54754.1 - 5.8e-07 29.0 0.7 1.5e-06 27.7 0.7 1.7 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 AAS54754.1 - 7.3e-06 26.1 0.1 2.4e-05 24.4 0.1 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 AAS54754.1 - 2.9e-05 24.2 0.0 7.7e-05 22.8 0.0 1.7 1 0 0 1 1 1 1 Dynamin family Septin PF00735.18 AAS54754.1 - 0.0028 17.0 1.0 0.0056 16.0 0.1 2.0 2 0 0 2 2 2 1 Septin Roc PF08477.13 AAS54754.1 - 0.0099 16.1 2.8 0.018 15.2 0.4 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase AAA_28 PF13521.6 AAS54754.1 - 0.033 14.4 0.0 0.084 13.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AAS54754.1 - 0.32 11.4 1.6 5.5 7.3 0.0 3.2 4 0 0 4 4 4 0 AAA ATPase domain DUF410 PF04190.13 AAS54755.1 - 2.2e-66 224.3 0.0 2.8e-66 223.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF410) NUDIX PF00293.28 AAS54756.1 - 9.1e-19 67.8 0.4 1.1e-18 67.6 0.4 1.1 1 0 0 1 1 1 1 NUDIX domain Longin PF13774.6 AAS54757.2 - 8.3e-19 67.4 0.1 1.3e-18 66.8 0.1 1.3 1 0 0 1 1 1 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 AAS54757.2 - 3.3e-14 52.4 0.0 5.5e-14 51.7 0.0 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF1664 PF07889.12 AAS54757.2 - 0.057 13.5 0.5 0.057 13.5 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DcpS_C PF11969.8 AAS54758.1 - 5.3e-34 117.1 0.0 9.7e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DcpS PF05652.12 AAS54758.1 - 1e-32 113.0 0.0 1.7e-32 112.3 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme (DcpS) N-terminal DUF4187 PF13821.6 AAS54759.2 - 5.2e-20 71.0 3.0 1e-19 70.1 3.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) G-patch PF01585.23 AAS54759.2 - 0.00011 22.0 2.1 0.00025 20.9 2.1 1.6 1 0 0 1 1 1 1 G-patch domain HutD PF05962.11 AAS54759.2 - 0.066 13.2 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 HutD Med4 PF10018.9 AAS54760.1 - 5e-35 121.0 0.2 1.5e-34 119.4 0.1 1.7 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 TMF_TATA_bd PF12325.8 AAS54760.1 - 0.13 12.5 2.8 0.25 11.6 0.7 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding MBOAT PF03062.19 AAS54761.2 - 1.4e-68 231.8 12.2 1.4e-68 231.8 12.2 1.8 1 1 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family DUF4004 PF13171.6 AAS54761.2 - 0.063 13.5 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4004) COX6C PF02937.15 AAS54761.2 - 0.63 10.2 3.4 0.68 10.1 0.2 2.8 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIc Ferrochelatase PF00762.19 AAS54762.1 - 3.8e-96 321.9 0.0 4.4e-96 321.7 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase NodZ PF05830.11 AAS54762.1 - 0.033 13.0 0.0 0.044 12.6 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein Z (NodZ) Cnd1 PF12717.7 AAS54763.2 - 1.2e-51 175.0 6.9 4.4e-45 153.6 0.3 4.1 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Cnd1_N PF12922.7 AAS54763.2 - 3.1e-45 154.0 0.2 3.1e-45 154.0 0.2 2.1 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1, N-term HEAT PF02985.22 AAS54763.2 - 1.2e-11 43.8 2.6 0.043 14.1 0.0 6.2 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 AAS54763.2 - 1.2e-10 41.6 0.0 0.0014 19.0 0.0 4.2 3 1 1 4 4 4 3 HEAT repeats HEAT_EZ PF13513.6 AAS54763.2 - 4e-07 30.4 0.6 0.31 11.6 0.0 5.0 4 0 0 4 4 4 2 HEAT-like repeat Cnd3 PF12719.7 AAS54763.2 - 4.7e-06 26.0 11.6 5.8e-05 22.4 1.0 3.3 3 1 0 3 3 3 2 Nuclear condensing complex subunits, C-term domain RTP1_C1 PF10363.9 AAS54763.2 - 0.0045 17.2 3.8 0.34 11.1 0.4 4.6 4 1 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 YtzH PF14165.6 AAS54763.2 - 0.053 13.9 2.1 0.13 12.7 0.0 2.8 3 0 0 3 3 3 0 YtzH-like protein Cohesin_HEAT PF12765.7 AAS54763.2 - 0.18 12.2 0.6 26 5.2 0.0 3.7 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Phage_GP20 PF06810.11 AAS54764.1 - 6.9e-05 22.7 7.4 0.00035 20.4 6.6 2.2 1 1 0 1 1 1 1 Phage minor structural protein GP20 Jnk-SapK_ap_N PF09744.9 AAS54764.1 - 0.00039 20.7 8.9 0.00098 19.4 8.9 1.7 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 HALZ PF02183.18 AAS54764.1 - 0.0011 19.1 10.9 4.1 7.7 0.0 4.8 4 1 1 5 5 4 1 Homeobox associated leucine zipper RasGAP_C PF03836.15 AAS54764.1 - 0.026 14.7 8.9 0.93 9.6 1.8 2.5 1 1 1 2 2 2 0 RasGAP C-terminus UPF0242 PF06785.11 AAS54764.1 - 0.054 13.6 13.4 0.05 13.7 11.9 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus APG6_N PF17675.1 AAS54764.1 - 0.13 12.8 14.1 0.22 12.1 7.1 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region bZIP_1 PF00170.21 AAS54764.1 - 0.14 12.3 6.8 0.39 10.9 1.2 3.1 2 1 1 3 3 3 0 bZIP transcription factor DUF641 PF04859.12 AAS54764.1 - 0.38 11.1 6.7 1.6 9.1 2.2 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FAM76 PF16046.5 AAS54764.1 - 0.64 9.3 6.9 1.2 8.4 6.9 1.5 1 0 0 1 1 1 0 FAM76 protein DUF3450 PF11932.8 AAS54764.1 - 0.66 9.2 10.9 4.7 6.4 6.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) BST2 PF16716.5 AAS54764.1 - 2.1 9.0 8.1 9 7.0 2.5 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 YabA PF06156.13 AAS54764.1 - 2.4 8.8 11.4 22 5.8 3.7 3.3 2 1 1 3 3 3 0 Initiation control protein YabA DivIC PF04977.15 AAS54764.1 - 2.8 7.8 9.0 12 5.8 1.7 2.8 1 1 2 3 3 3 0 Septum formation initiator DUF724 PF05266.14 AAS54764.1 - 3.9 7.2 8.4 6.6 6.5 7.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF724) ATG16 PF08614.11 AAS54764.1 - 6 7.0 24.1 2.9 8.1 5.5 3.0 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 AAS54764.1 - 7.6 6.7 12.9 3.6 7.7 4.9 2.9 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF1043 PF06295.12 AAS54764.1 - 8.6 6.4 8.4 4.9 7.2 4.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) CBM_21 PF03370.13 AAS54765.2 - 2.6e-26 92.0 5.1 4.8e-26 91.1 5.1 1.4 1 0 0 1 1 1 1 Carbohydrate/starch-binding module (family 21) CBM53 PF16760.5 AAS54765.2 - 0.00038 21.0 6.0 0.0018 18.8 6.0 2.0 1 1 0 1 1 1 1 Starch/carbohydrate-binding module (family 53) MCM PF00493.23 AAS54766.1 - 6.4e-105 349.2 0.1 1.2e-104 348.3 0.0 1.5 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 AAS54766.1 - 3.3e-36 123.9 0.0 6.6e-36 122.9 0.0 1.5 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AAS54766.1 - 9.5e-29 99.7 2.7 9.5e-29 99.7 2.7 2.1 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 AAS54766.1 - 8.5e-15 55.2 0.3 2.2e-14 53.9 0.3 1.7 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 AAS54766.1 - 1.7e-06 28.1 0.0 4.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 AAS54766.1 - 2.9e-06 26.8 0.0 0.00055 19.4 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 AAS54766.1 - 0.00032 20.6 0.0 0.0012 18.7 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 AAS54766.1 - 0.028 14.1 0.2 1.1 9.0 0.0 2.6 3 0 0 3 3 3 0 Sigma-54 interaction domain Imm35 PF15567.6 AAS54766.1 - 0.12 12.5 0.0 0.38 11.0 0.0 1.8 1 0 0 1 1 1 0 Immunity protein 35 AAA PF00004.29 AAS54766.1 - 0.13 12.7 0.1 0.67 10.4 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1690 PF07956.11 AAS54766.1 - 0.99 9.8 4.0 5.7 7.4 0.9 2.3 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) LSM PF01423.22 AAS54767.1 - 1.3e-17 63.2 0.2 1.8e-17 62.8 0.2 1.1 1 0 0 1 1 1 1 LSM domain Hfq PF17209.3 AAS54767.1 - 0.042 13.5 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 Hfq protein DEAD PF00270.29 AAS54768.1 - 2.4e-36 125.2 0.9 4.1e-36 124.4 0.9 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS54768.1 - 1.2e-31 109.3 0.9 3.3e-31 107.9 0.0 2.2 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54768.1 - 9.3e-06 25.7 0.1 3.1e-05 24.1 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 AAS54768.1 - 0.079 12.2 0.9 5 6.3 0.0 2.7 2 1 0 2 2 2 0 SecA DEAD-like domain DnaI_N PF07319.11 AAS54768.1 - 0.11 13.2 4.4 14 6.5 0.5 3.4 2 2 0 2 2 2 0 Primosomal protein DnaI N-terminus CPSF73-100_C PF11718.8 AAS54769.2 - 2.4e-56 190.7 1.4 4e-56 190.0 1.4 1.4 1 0 0 1 1 1 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Beta-Casp PF10996.8 AAS54769.2 - 6.5e-31 106.9 0.0 1.4e-30 105.8 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 AAS54769.2 - 2.1e-21 76.9 0.8 3.4e-21 76.2 0.8 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_6 PF16661.5 AAS54769.2 - 1.1e-19 70.6 0.0 2.6e-19 69.4 0.0 1.6 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 AAS54769.2 - 5.3e-17 61.5 0.0 1.1e-16 60.4 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 AAS54769.2 - 4.4e-05 23.1 0.1 0.0009 18.8 0.2 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AAS54769.2 - 0.00017 21.5 0.1 0.00055 19.9 0.1 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Beta_lactamase3 PF17030.5 AAS54769.2 - 0.036 13.3 0.0 0.08 12.2 0.0 1.5 1 0 0 1 1 1 0 Putative beta-lactamase-like family Fungal_trans PF04082.18 AAS54770.2 - 1.7e-16 60.1 0.1 3.7e-16 59.0 0.2 1.6 2 0 0 2 2 2 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS54770.2 - 4.5e-05 23.5 9.1 4.5e-05 23.5 9.1 2.0 2 0 0 2 2 2 1 Fungal Zn(2)-Cys(6) binuclear cluster domain RF-1 PF00472.20 AAS54771.1 - 3.6e-20 72.0 2.3 5.2e-20 71.5 2.3 1.2 1 0 0 1 1 1 1 RF-1 domain DUF1640 PF07798.11 AAS54772.1 - 5.6e-24 85.1 2.0 8.2e-24 84.6 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) AvrPphF-ORF-2 PF09143.10 AAS54772.1 - 0.046 13.6 0.3 0.072 13.0 0.3 1.2 1 0 0 1 1 1 0 AvrPphF-ORF-2 ECH_1 PF00378.20 AAS54773.1 - 9.7e-13 48.0 0.0 1.6e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 AAS54773.1 - 8.1e-07 28.8 0.0 1.5e-06 28.0 0.0 1.4 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Methyltransf_16 PF10294.9 AAS54774.1 - 1.8e-10 40.8 0.0 2.3e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_23 PF13489.6 AAS54774.1 - 0.065 13.1 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain WH1 PF00568.23 AAS54775.1 - 8.6e-32 109.4 0.0 1.2e-31 108.9 0.0 1.2 1 0 0 1 1 1 1 WH1 domain WH2 PF02205.20 AAS54775.1 - 0.00032 20.4 1.0 0.00066 19.4 1.0 1.6 1 0 0 1 1 1 1 WH2 motif GCIP PF13324.6 AAS54776.1 - 3.1e-35 122.0 3.2 4.5e-35 121.5 2.9 1.4 1 1 0 1 1 1 1 Grap2 and cyclin-D-interacting GCN5L1 PF06320.13 AAS54776.1 - 0.029 14.5 1.6 0.13 12.4 0.3 2.3 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) DASH_Dad3 PF08656.10 AAS54776.1 - 0.048 13.8 5.9 7 6.8 0.1 4.1 3 1 0 3 3 3 0 DASH complex subunit Dad3 YkyA PF10368.9 AAS54776.1 - 0.7 9.5 5.0 3.5 7.3 0.3 3.0 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein Ribosomal_S30 PF04758.14 AAS54777.1 - 9.5e-30 102.6 6.7 1e-29 102.4 6.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S30 Aminotran_5 PF00266.19 AAS54778.1 - 3.4e-35 121.7 0.0 3.9e-35 121.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Hus1 PF04005.12 AAS54779.2 - 2.7e-26 92.4 0.0 4.1e-26 91.8 0.0 1.2 1 0 0 1 1 1 1 Hus1-like protein PAN_3 PF08277.12 AAS54779.2 - 0.15 11.9 0.4 0.37 10.6 0.4 1.6 1 0 0 1 1 1 0 PAN-like domain GTP_EFTU PF00009.27 AAS54780.1 - 4.1e-48 163.5 0.0 8.3e-48 162.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain LepA_C PF06421.12 AAS54780.1 - 1.6e-40 137.6 8.2 3.6e-40 136.4 8.2 1.6 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 AAS54780.1 - 2.7e-20 72.2 0.0 5e-20 71.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AAS54780.1 - 2.6e-06 27.7 0.6 1.4e-05 25.4 0.3 2.3 1 1 1 2 2 2 2 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AAS54780.1 - 3.2e-05 24.0 0.3 0.00014 21.9 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 AAS54780.1 - 5.4e-05 22.8 0.2 0.002 17.8 0.0 2.4 2 0 0 2 2 2 1 Ras family RF3_C PF16658.5 AAS54780.1 - 0.0015 18.3 0.3 0.0059 16.4 0.0 2.1 2 1 1 3 3 3 1 Class II release factor RF3, C-terminal domain SRPRB PF09439.10 AAS54780.1 - 0.0079 15.6 0.0 0.019 14.4 0.0 1.7 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 AAS54780.1 - 0.012 15.8 0.0 2 8.7 0.0 2.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase EFG_II PF14492.6 AAS54780.1 - 0.017 15.2 0.0 0.05 13.7 0.0 1.9 1 0 0 1 1 1 0 Elongation Factor G, domain II MMR_HSR1_Xtn PF16897.5 AAS54780.1 - 0.04 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain NAD_binding_10 PF13460.6 AAS54781.1 - 4.9e-05 23.3 0.0 0.00028 20.8 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 AAS54781.1 - 0.0011 18.1 0.0 0.0025 16.9 0.0 1.5 2 0 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 AAS54781.1 - 0.0018 17.8 0.0 0.0027 17.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 AAS54781.1 - 0.0024 17.1 0.0 1.6 7.8 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein KR PF08659.10 AAS54781.1 - 0.017 15.1 0.0 0.033 14.1 0.0 1.5 1 0 0 1 1 1 0 KR domain BDHCT PF08072.11 AAS54781.1 - 0.081 13.0 0.9 0.2 11.7 0.9 1.7 1 0 0 1 1 1 0 BDHCT (NUC031) domain IF-2B PF01008.17 AAS54782.1 - 3.9e-77 259.2 0.1 6.7e-77 258.5 0.1 1.4 1 1 0 1 1 1 1 Initiation factor 2 subunit family Gag_p24 PF00607.20 AAS54782.1 - 0.046 13.6 0.3 0.085 12.7 0.3 1.5 1 0 0 1 1 1 0 gag gene protein p24 (core nucleocapsid protein) Arf PF00025.21 AAS54782.1 - 0.089 12.2 0.0 0.19 11.1 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family ROK PF00480.20 AAS54782.1 - 0.37 10.2 1.6 15 4.9 0.4 2.2 1 1 1 2 2 2 0 ROK family TPR_2 PF07719.17 AAS54783.1 - 5.2e-05 23.1 0.1 0.0014 18.6 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 AAS54783.1 - 0.0002 21.0 0.0 0.0068 16.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54783.1 - 0.00072 19.6 0.1 0.0045 17.1 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 AAS54783.1 - 0.016 15.7 2.0 0.082 13.4 0.3 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54783.1 - 0.033 14.5 1.3 1.1 9.6 0.3 2.6 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 AAS54783.1 - 0.045 14.6 2.5 0.16 12.9 0.2 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54783.1 - 0.071 13.8 1.5 0.42 11.3 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AAS54783.1 - 0.08 13.0 0.2 0.08 13.0 0.2 2.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Ras PF00071.22 AAS54784.1 - 1.2e-50 171.3 0.0 1.5e-50 171.0 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 AAS54784.1 - 1e-30 106.4 0.1 2.7e-30 105.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 AAS54784.1 - 2.1e-11 43.6 0.0 2.9e-11 43.1 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 AAS54784.1 - 0.00075 19.6 0.0 0.0016 18.5 0.0 1.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 AAS54784.1 - 0.00098 19.5 0.1 0.0065 16.8 0.1 2.1 1 1 0 1 1 1 1 RNA helicase Gtr1_RagA PF04670.12 AAS54784.1 - 0.0015 17.9 0.0 0.0021 17.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 AAS54784.1 - 0.017 14.6 0.0 0.029 13.8 0.0 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit Pox_A32 PF04665.12 AAS54784.1 - 0.019 14.4 0.1 0.036 13.5 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A32 protein G-alpha PF00503.20 AAS54784.1 - 0.02 14.0 2.3 2.1 7.4 0.1 2.8 2 1 1 3 3 3 0 G-protein alpha subunit GTP_EFTU PF00009.27 AAS54784.1 - 0.024 14.2 0.5 0.11 12.0 0.0 2.0 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 AAS54784.1 - 0.024 14.5 0.1 8.2 6.3 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ATPase PF06745.13 AAS54784.1 - 0.026 13.9 0.2 0.041 13.2 0.2 1.2 1 0 0 1 1 1 0 KaiC AAA_7 PF12775.7 AAS54784.1 - 0.032 13.7 0.0 0.055 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AAS54784.1 - 0.054 13.2 0.1 0.09 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 AAS54784.1 - 0.091 12.8 0.1 0.21 11.6 0.1 1.6 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 AAS54784.1 - 0.097 12.8 0.2 0.22 11.7 0.2 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AAS54784.1 - 0.13 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Septin PF00735.18 AAS54784.1 - 0.14 11.4 0.3 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 Septin ATP_sub_h PF10775.9 AAS54785.2 - 2.9e-21 75.2 0.1 3.9e-21 74.8 0.1 1.2 1 0 0 1 1 1 1 ATP synthase complex subunit h zf-AN1 PF01428.16 AAS54786.1 - 5.7e-11 42.4 4.3 5.7e-11 42.4 4.3 1.7 1 1 1 2 2 2 1 AN1-like Zinc finger Transp_Tc5_C PF04236.15 AAS54786.1 - 0.22 11.9 5.0 0.34 11.3 5.0 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain C5HCH PF17982.1 AAS54786.1 - 0.48 10.6 7.5 0.87 9.8 7.5 1.5 1 0 0 1 1 1 0 NSD Cys-His rich domain Hydrolase_6 PF13344.6 AAS54787.2 - 5.4e-27 93.9 0.0 1.1e-26 92.9 0.0 1.5 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AAS54787.2 - 2.7e-25 88.2 0.0 5.8e-25 87.2 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AAS54787.2 - 7.1e-06 26.5 0.0 1.1 9.5 0.0 3.2 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AAS54787.2 - 0.0011 19.1 0.0 0.094 12.8 0.0 2.7 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase TP_methylase PF00590.20 AAS54788.2 - 2.1e-46 158.6 1.0 3.8e-46 157.7 1.0 1.5 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Sirohm_synth_M PF14824.6 AAS54788.2 - 3.4e-08 32.8 0.0 7.4e-08 31.7 0.0 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central NAD_binding_7 PF13241.6 AAS54788.2 - 7.2e-08 32.8 0.0 1.6e-07 31.7 0.0 1.6 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_C PF14823.6 AAS54788.2 - 0.0065 16.1 0.2 0.23 11.1 0.1 2.4 2 0 0 2 2 2 1 Sirohaem biosynthesis protein C-terminal Nro1 PF12753.7 AAS54789.1 - 4.2e-167 556.3 8.0 4.7e-167 556.1 8.0 1.0 1 0 0 1 1 1 1 Nuclear pore complex subunit Nro1 TPR_19 PF14559.6 AAS54789.1 - 0.0053 17.2 0.9 0.067 13.7 0.0 2.9 2 1 0 3 3 3 1 Tetratricopeptide repeat DUF45 PF01863.17 AAS54789.1 - 0.01 15.9 1.5 0.016 15.3 1.0 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF45 TPR_14 PF13428.6 AAS54789.1 - 0.026 15.3 0.5 29 5.9 0.1 3.6 2 1 0 2 2 2 0 Tetratricopeptide repeat FAST_1 PF06743.15 AAS54789.1 - 0.09 12.7 0.0 0.71 9.9 0.0 2.4 3 0 0 3 3 3 0 FAST kinase-like protein, subdomain 1 HMGL-like PF00682.19 AAS54789.1 - 0.15 11.6 0.1 0.24 10.9 0.1 1.2 1 0 0 1 1 1 0 HMGL-like TRAPP PF04051.16 AAS54790.2 - 1.7e-31 108.9 0.0 2.1e-31 108.6 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Dsl1_N PF11988.8 AAS54790.2 - 0.083 11.9 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal Acyltransferase PF01553.21 AAS54791.2 - 2.4e-09 36.9 0.0 3.2e-08 33.3 0.0 2.2 1 1 0 1 1 1 1 Acyltransferase Methyltransf_28 PF02636.17 AAS54792.2 - 3e-07 30.4 0.0 5e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase XRN_M PF17846.1 AAS54793.2 - 4.9e-132 441.0 0.1 1.6e-129 432.7 0.0 2.4 2 1 0 2 2 2 1 Xrn1 helical domain XRN_N PF03159.18 AAS54793.2 - 2.6e-98 328.3 0.0 5.5e-98 327.2 0.0 1.6 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus STD1 PF17235.2 AAS54794.1 - 7.7e-67 224.9 1.4 1.8e-66 223.7 0.1 1.8 2 0 0 2 2 2 1 STD1/MTH1 PseudoU_synth_2 PF00849.22 AAS54795.1 - 3.1e-27 95.6 0.0 5.3e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 RNA pseudouridylate synthase SH3_1 PF00018.28 AAS54796.1 - 9.1e-08 31.6 0.2 2.4e-07 30.2 0.2 1.8 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 AAS54796.1 - 1.7e-06 27.8 0.2 3.6e-06 26.7 0.2 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 AAS54796.1 - 0.0021 17.7 0.1 0.0072 16.0 0.1 2.0 1 0 0 1 1 1 1 Variant SH3 domain Clathrin_lg_ch PF01086.17 AAS54799.1 - 7.6e-39 134.1 7.4 8.7e-39 133.9 7.4 1.0 1 0 0 1 1 1 1 Clathrin light chain RhlB PF12300.8 AAS54799.1 - 0.013 15.6 0.7 0.017 15.2 0.7 1.2 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Urm1 PF09138.11 AAS54799.1 - 0.059 13.7 0.1 0.11 12.8 0.1 1.4 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) DUF3507 PF12015.8 AAS54799.1 - 0.11 12.2 0.9 0.15 11.7 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) SVIP PF15811.5 AAS54799.1 - 3.1 8.3 9.4 6.4 7.3 9.4 1.5 1 0 0 1 1 1 0 Small VCP/p97-interacting protein Trs65 PF12735.7 AAS54800.1 - 6.5e-27 94.8 0.9 3.6e-14 52.9 0.6 2.1 1 1 1 2 2 2 2 TRAPP trafficking subunit Trs65 Bot1p PF12298.8 AAS54801.2 - 1.2e-54 185.0 1.6 1.8e-54 184.5 1.6 1.2 1 0 0 1 1 1 1 Eukaryotic mitochondrial regulator protein Sad1_UNC PF07738.13 AAS54802.1 - 6.3e-07 29.5 1.1 9.4e-07 28.9 0.0 1.8 2 0 0 2 2 2 1 Sad1 / UNC-like C-terminal Baculo_PEP_C PF04513.12 AAS54802.1 - 0.042 13.9 5.6 0.14 12.2 2.9 2.7 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 AAS54802.1 - 0.089 12.7 4.0 0.41 10.5 2.0 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Sds3 PF08598.11 AAS54802.1 - 0.21 11.6 5.7 0.29 11.1 5.7 1.5 1 1 0 1 1 1 0 Sds3-like Nbl1_Borealin_N PF10444.9 AAS54802.1 - 0.39 10.4 9.1 0.033 13.8 2.8 2.3 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal FlaC_arch PF05377.11 AAS54802.1 - 0.63 10.5 7.4 2.2 8.7 0.5 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) FapA PF03961.13 AAS54802.1 - 1 7.9 3.2 1.6 7.2 3.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A ABC_tran_CTD PF16326.5 AAS54802.1 - 2.5 8.4 7.9 0.51 10.6 1.0 2.9 3 0 0 3 3 3 0 ABC transporter C-terminal domain DUF445 PF04286.12 AAS54802.1 - 3.5 7.3 8.1 2.2 8.0 5.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Cpn60_TCP1 PF00118.24 AAS54804.1 - 1.9e-160 534.7 5.8 2.2e-160 534.5 5.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Mad3_BUB1_I PF08311.12 AAS54805.2 - 7.9e-39 132.5 0.6 7.9e-39 132.5 0.6 2.0 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 Mad3_BUB1_II PF08171.11 AAS54805.2 - 5.3e-28 97.0 0.1 1.6e-26 92.3 0.0 2.7 2 0 0 2 2 2 1 Mad3/BUB1 homology region 2 Pkinase PF00069.25 AAS54805.2 - 2.6e-18 66.3 0.0 4.7e-18 65.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54805.2 - 0.00019 20.8 0.0 0.00043 19.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I_2 PF17014.5 AAS54805.2 - 0.00075 19.6 0.1 0.0034 17.5 0.0 2.1 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein Kinase-like PF14531.6 AAS54805.2 - 0.015 14.6 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF3828 PF12883.7 AAS54805.2 - 2.4 8.5 5.2 30 5.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3828) VTC PF09359.10 AAS54806.1 - 7.2e-101 337.2 0.1 1.4e-100 336.3 0.1 1.5 1 0 0 1 1 1 1 VTC domain SPX PF03105.19 AAS54806.1 - 5.3e-11 43.1 12.4 2.1e-05 24.6 1.6 3.5 2 1 1 3 3 3 3 SPX domain DUF202 PF02656.15 AAS54806.1 - 7.4e-09 35.9 2.6 1.7e-08 34.8 2.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) RNA_pol_Rpb4 PF03874.16 AAS54807.1 - 3.9e-33 114.4 3.2 4.5e-33 114.2 3.2 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb4 Glyco_hydro_16 PF00722.21 AAS54808.1 - 9.2e-46 155.5 0.4 9.2e-46 155.5 0.4 2.1 2 1 0 2 2 2 1 Glycosyl hydrolases family 16 DUF1080 PF06439.11 AAS54808.1 - 0.031 14.4 0.0 0.053 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1080) AA_permease PF00324.21 AAS54809.1 - 2.2e-133 445.3 33.3 2.6e-133 445.1 33.3 1.0 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 AAS54809.1 - 2.1e-31 109.2 37.5 2.6e-31 108.9 37.5 1.0 1 0 0 1 1 1 1 Amino acid permease UPF0139 PF03669.13 AAS54809.1 - 9.9 6.1 8.2 0.73 9.7 0.5 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0139) EIF_2_alpha PF07541.12 AAS54810.2 - 1.3e-39 134.9 1.0 2.1e-39 134.2 0.4 1.7 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AAS54810.2 - 1e-15 57.8 2.0 1e-15 57.8 2.0 1.7 2 0 0 2 2 2 1 S1 RNA binding domain SLIDE PF09111.10 AAS54810.2 - 0.017 15.1 0.5 0.07 13.2 0.0 2.3 2 1 1 3 3 3 0 SLIDE DUF1413 PF07205.11 AAS54810.2 - 0.15 12.1 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) Memo PF01875.17 AAS54811.2 - 2.8e-84 282.4 0.0 3.3e-84 282.2 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein ATP-sulfurylase PF01747.17 AAS54812.1 - 5.6e-83 277.6 0.0 7.2e-83 277.2 0.0 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 AAS54812.1 - 3.1e-53 179.7 0.0 4.7e-53 179.1 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain Biotin_lipoyl PF00364.22 AAS54813.2 - 3.4e-19 68.5 0.8 8e-19 67.3 0.8 1.7 1 0 0 1 1 1 1 Biotin-requiring enzyme E3_binding PF02817.17 AAS54813.2 - 1.4e-06 28.5 0.0 3.6e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 e3 binding domain FGGY_C PF02782.16 AAS54814.2 - 7.2e-18 65.0 0.0 2e-17 63.6 0.0 1.8 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 AAS54814.2 - 6.7e-17 61.9 0.0 1.2e-11 44.7 0.0 2.6 2 1 0 2 2 2 2 FGGY family of carbohydrate kinases, N-terminal domain SPC12 PF06645.13 AAS54815.1 - 1.6e-18 66.5 0.1 1.8e-18 66.3 0.1 1.1 1 0 0 1 1 1 1 Microsomal signal peptidase 12 kDa subunit (SPC12) Candida_ALS_N PF11766.8 AAS54817.3 - 9.3e-66 221.6 0.4 9.3e-66 221.6 0.4 2.7 3 1 0 3 3 3 1 Cell-wall agglutinin N-terminal ligand-sugar binding NAD_binding_6 PF08030.12 AAS54818.1 - 1.5e-18 67.4 0.0 2.6e-18 66.6 0.0 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 AAS54818.1 - 1.1e-17 64.1 0.0 1.9e-17 63.3 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 AAS54818.1 - 2.8e-17 63.0 10.8 2.8e-17 63.0 10.8 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DUF4079 PF13301.6 AAS54818.1 - 0.25 11.5 6.1 30 4.8 6.1 3.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF2070 PF09843.9 AAS54818.1 - 5.9 5.1 9.9 10 4.3 9.9 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Oxidored_FMN PF00724.20 AAS54819.1 - 9.1e-118 393.4 0.0 1.1e-117 393.2 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family DnaT PF17948.1 AAS54819.1 - 0.087 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 DnaT DNA-binding domain Aminotran_4 PF01063.19 AAS54820.1 - 3.4e-19 69.6 0.0 8.6e-19 68.3 0.0 1.5 1 1 0 1 1 1 1 Amino-transferase class IV Kdo PF06293.14 AAS54821.1 - 1.2e-07 31.3 0.0 2.1e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AAS54821.1 - 0.0024 17.8 0.0 0.65 9.9 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 AAS54821.1 - 0.024 14.0 0.0 0.035 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain tRNA-synt_1g PF09334.11 AAS54822.1 - 3.2e-157 523.3 0.4 4.2e-157 522.9 0.4 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) MetRS-N PF09635.10 AAS54822.1 - 3.3e-58 195.5 0.0 9.2e-58 194.1 0.0 1.8 1 0 0 1 1 1 1 MetRS-N binding domain tRNA-synt_1 PF00133.22 AAS54822.1 - 4.8e-10 38.3 0.3 0.0002 19.7 0.4 2.4 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 AAS54822.1 - 0.021 14.2 0.0 0.061 12.7 0.0 1.7 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain Anticodon_1 PF08264.13 AAS54822.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA Sigma54_CBD PF04963.13 AAS54822.1 - 0.091 12.6 0.0 0.46 10.3 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 factor, core binding domain DEAD PF00270.29 AAS54823.2 - 1.8e-46 158.1 0.9 3.6e-46 157.1 0.1 1.9 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AAS54823.2 - 4e-25 88.3 0.0 3.7e-24 85.2 0.0 2.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 AAS54823.2 - 2.6e-18 66.0 0.1 6.1e-18 64.8 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ResIII PF04851.15 AAS54823.2 - 6.4e-06 26.3 0.0 1.3e-05 25.3 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AAS54823.2 - 6.1e-05 22.4 0.1 0.00021 20.6 0.0 1.8 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase SecA_DEAD PF07517.14 AAS54823.2 - 0.0021 17.4 0.0 0.0051 16.1 0.0 1.6 1 1 0 1 1 1 1 SecA DEAD-like domain AAA_30 PF13604.6 AAS54823.2 - 0.068 12.9 0.1 0.82 9.3 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AAS54823.2 - 0.12 12.6 1.6 0.39 11.0 0.8 2.3 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 AAS54824.1 - 2.8e-49 167.9 0.0 2.5e-41 141.8 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 AAS54824.1 - 3.7e-22 78.9 0.1 4.1e-20 72.1 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 AAS54824.1 - 0.00031 19.6 0.0 0.00051 18.9 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AAS54824.1 - 0.0052 16.1 0.0 0.034 13.5 0.0 2.0 1 1 0 1 1 1 1 Kinase-like GTP_cyclohydroI PF01227.22 AAS54825.1 - 1.3e-75 252.7 0.3 1.6e-75 252.5 0.3 1.1 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 AAS54825.1 - 0.00014 21.9 0.0 0.00057 20.0 0.0 2.0 2 0 0 2 2 2 1 QueF-like protein DnaJ_CXXCXGXG PF00684.19 AAS54826.1 - 4.4e-05 23.8 8.7 0.0029 17.9 0.6 2.3 2 0 0 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 AAS54826.1 - 0.019 14.9 7.3 0.19 11.7 0.2 3.2 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 AAS54826.1 - 0.056 13.6 0.3 0.056 13.6 0.3 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5351) OrfB_Zn_ribbon PF07282.11 AAS54826.1 - 1.4 8.9 4.9 0.99 9.4 1.3 2.0 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Got1 PF04178.12 AAS54827.1 - 4.6e-12 46.4 17.9 1.6e-11 44.6 17.5 1.8 1 1 1 2 2 2 2 Got1/Sft2-like family DUF373 PF04123.13 AAS54827.1 - 2.2 7.7 7.0 1.6 8.1 4.6 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF373) GCP_C_terminal PF04130.13 AAS54828.2 - 9.1e-38 130.5 5.7 2e-37 129.4 5.7 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 AAS54828.2 - 5.5e-33 114.9 2.1 7.4e-33 114.5 0.9 1.8 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal N1221 PF07923.13 AAS54829.1 - 2e-64 217.6 0.5 3.3e-64 216.8 0.5 1.4 1 0 0 1 1 1 1 N1221-like protein DUF3402 PF11882.8 AAS54829.1 - 8.4e-56 190.0 9.2 4.7e-32 111.7 5.4 3.3 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) AD PF09793.9 AAS54830.1 - 3.5e-16 59.1 0.0 5.3e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain Arginase PF00491.21 AAS54830.1 - 0.085 12.3 0.1 0.13 11.8 0.1 1.2 1 0 0 1 1 1 0 Arginase family DSPc PF00782.20 AAS54831.1 - 3.1e-10 40.0 0.0 7.1e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 AAS54831.1 - 0.13 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase PF00102.27 AAS54831.1 - 0.16 11.5 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase AAA_18 PF13238.6 AAS54832.2 - 0.0043 17.6 0.1 0.013 16.0 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 AAS54832.2 - 0.0044 17.2 0.0 0.018 15.2 0.0 2.3 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 AAS54832.2 - 0.033 13.9 0.0 0.057 13.2 0.0 1.6 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 AAS54832.2 - 0.057 13.3 0.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 AAS54832.2 - 0.077 12.3 0.1 0.14 11.4 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 AAS54832.2 - 0.14 12.6 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain FeS_assembly_P PF01883.19 AAS54833.1 - 1.3e-07 31.7 0.2 2.6e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 Iron-sulfur cluster assembly protein TEX13 PF15186.6 AAS54833.1 - 0.002 17.8 1.1 0.0022 17.7 0.1 1.6 2 0 0 2 2 2 1 Testis-expressed sequence 13 protein family CDP-OH_P_transf PF01066.21 AAS54834.1 - 1.1e-16 61.4 0.0 1.1e-16 61.4 0.0 3.3 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Tom22 PF04281.13 AAS54835.1 - 8.4e-49 164.9 1.5 9.5e-49 164.7 1.5 1.0 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 SID-1_RNA_chan PF13965.6 AAS54835.1 - 0.027 12.9 0.1 0.035 12.5 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GNAT_acetyltr_2 PF13718.6 AAS54836.2 - 2.7e-98 327.9 0.3 7.3e-98 326.5 0.0 2.0 2 0 0 2 2 2 1 GNAT acetyltransferase 2 tRNA_bind_2 PF13725.6 AAS54836.2 - 3.3e-88 295.4 1.4 7.9e-88 294.1 1.4 1.7 1 0 0 1 1 1 1 Possible tRNA binding domain Helicase_RecD PF05127.14 AAS54836.2 - 7.9e-64 214.8 0.1 4.3e-63 212.3 0.0 2.3 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.11 AAS54836.2 - 5.3e-34 116.0 0.5 1.4e-33 114.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1726) AAA_30 PF13604.6 AAS54836.2 - 0.0035 17.1 0.0 0.31 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AAS54836.2 - 0.014 15.6 0.0 1.3 9.3 0.0 2.8 2 0 0 2 2 2 0 AAA domain DEAD PF00270.29 AAS54836.2 - 0.12 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 DEAD/DEAH box helicase NDT80_PhoG PF05224.12 AAS54837.1 - 6.6e-69 231.9 0.8 1.7e-68 230.5 0.8 1.7 1 0 0 1 1 1 1 NDT80 / PhoG like DNA-binding family RBR PF17208.3 AAS54837.1 - 4.5 8.0 5.8 1.1 10.0 1.6 2.2 2 0 0 2 2 2 0 RNA binding Region HIM1 PF08732.10 AAS54838.2 - 1.9e-58 196.7 0.5 3.3e-58 195.9 0.0 1.6 2 0 0 2 2 2 1 HIM1 Macoilin PF09726.9 AAS54838.2 - 0.19 10.2 10.4 0.25 9.8 10.4 1.1 1 0 0 1 1 1 0 Macoilin family FAM60A PF15396.6 AAS54838.2 - 1.4 8.8 9.5 2.7 7.9 9.5 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF4692 PF15763.5 AAS54838.2 - 1.8 9.0 13.5 7.7 7.0 5.1 2.3 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) MID_MedPIWI PF18296.1 AAS54838.2 - 3.2 7.5 12.3 6.1 6.6 12.3 1.4 1 0 0 1 1 1 0 MID domain of medPIWI V_ATPase_I PF01496.19 AAS54838.2 - 5.6 4.7 6.7 7.7 4.3 6.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-O PF09496.10 AAS54839.2 - 2.7e-13 50.4 0.2 8.7e-13 48.7 0.0 2.0 2 0 0 2 2 2 1 Cenp-O kinetochore centromere component CCDC53 PF10152.9 AAS54839.2 - 0.016 15.6 2.4 0.039 14.4 1.2 1.9 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex DUF4404 PF14357.6 AAS54839.2 - 0.072 13.7 2.7 0.14 12.8 2.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) Csm1_N PF18504.1 AAS54839.2 - 0.073 13.4 1.5 0.18 12.2 1.5 1.7 1 0 0 1 1 1 0 Csm1 N-terminal domain Prefoldin_2 PF01920.20 AAS54839.2 - 0.091 12.7 1.0 1.4 8.9 0.9 2.2 2 0 0 2 2 2 0 Prefoldin subunit FlaC_arch PF05377.11 AAS54839.2 - 0.18 12.2 1.0 0.36 11.3 1.0 1.4 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) SKA1 PF07160.12 AAS54839.2 - 0.27 11.0 2.2 0.4 10.5 2.2 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Scs3p PF10261.9 AAS54840.2 - 3.9e-24 85.5 12.4 1.5e-17 63.9 1.3 2.4 1 1 1 2 2 2 2 Inositol phospholipid synthesis and fat-storage-inducing TM CbtA PF09490.10 AAS54840.2 - 0.0005 19.9 1.6 0.035 13.9 0.9 2.5 2 0 0 2 2 2 2 Probable cobalt transporter subunit (CbtA) PAP2 PF01569.21 AAS54840.2 - 0.00099 18.9 4.7 0.00099 18.9 4.7 1.7 2 1 0 2 2 2 1 PAP2 superfamily SQHop_cyclase_C PF13243.6 AAS54841.2 - 1.6e-44 152.3 0.0 1.1e-43 149.6 0.0 2.0 2 0 0 2 2 2 1 Squalene-hopene cyclase C-terminal domain SQHop_cyclase_N PF13249.6 AAS54841.2 - 4e-38 131.2 0.1 1.3e-32 113.1 0.0 3.5 2 1 2 4 4 4 4 Squalene-hopene cyclase N-terminal domain Prenyltrans PF00432.21 AAS54841.2 - 4.1e-26 90.4 0.3 9.4e-09 34.9 0.0 4.1 3 0 0 3 3 3 3 Prenyltransferase and squalene oxidase repeat TED_complement PF07678.14 AAS54841.2 - 0.0026 16.8 0.0 0.0086 15.1 0.0 1.8 2 0 0 2 2 2 1 A-macroglobulin TED domain Pec_lyase PF09492.10 AAS54841.2 - 0.15 11.4 0.1 2 7.6 0.0 2.4 1 1 1 2 2 2 0 Pectic acid lyase Ubiq-assoc PF09145.10 AAS54842.1 - 3e-19 68.7 0.6 3e-19 68.7 0.6 2.0 2 0 0 2 2 2 1 Ubiquitin-associated MIT PF04212.18 AAS54842.1 - 0.00048 20.1 1.5 0.28 11.3 0.6 2.8 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain DnaJ PF00226.31 AAS54842.1 - 0.0018 18.4 0.0 0.041 14.0 0.0 2.5 2 0 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 AAS54842.1 - 0.0052 16.5 0.3 12 5.9 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 AAS54842.1 - 0.0055 16.7 1.4 1.2 9.4 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54842.1 - 0.0056 17.0 0.5 4 7.8 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54842.1 - 0.014 15.6 3.2 2.2 8.7 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat DNA_pol3_delta PF06144.13 AAS54842.1 - 0.054 13.3 0.9 0.093 12.5 0.1 1.8 2 0 0 2 2 2 0 DNA polymerase III, delta subunit ComR_TPR PF18710.1 AAS54842.1 - 0.074 12.6 0.2 0.14 11.6 0.2 1.4 1 0 0 1 1 1 0 ComR tetratricopeptide TPR_6 PF13174.6 AAS54842.1 - 0.11 13.1 0.7 2.4 9.0 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DivIC PF04977.15 AAS54843.1 - 0.0012 18.6 0.4 0.0023 17.7 0.4 1.4 1 0 0 1 1 1 1 Septum formation initiator DUF4713 PF15831.5 AAS54843.1 - 0.018 15.5 1.5 0.03 14.7 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) Glyco_trans_1_2 PF13524.6 AAS54843.1 - 0.041 14.3 0.4 0.073 13.5 0.4 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 TORC_M PF12885.7 AAS54843.1 - 0.067 13.1 0.2 0.096 12.6 0.2 1.2 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain Nop10p PF04135.12 AAS54844.1 - 9.4e-23 80.0 0.3 1.3e-22 79.6 0.3 1.2 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family DASH_Dad4 PF08650.10 AAS54845.1 - 2.5e-32 110.7 0.4 2.8e-32 110.5 0.4 1.0 1 0 0 1 1 1 1 DASH complex subunit Dad4 DivIC PF04977.15 AAS54845.1 - 0.029 14.1 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 Septum formation initiator CCDC-167 PF15188.6 AAS54845.1 - 0.059 13.7 0.1 0.078 13.3 0.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 FAM117 PF15388.6 AAS54845.1 - 0.15 11.4 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM117 DASH_Dad1 PF08649.10 AAS54845.1 - 0.28 11.4 3.1 0.83 9.9 0.8 2.1 1 1 1 2 2 2 0 DASH complex subunit Dad1 Oxysterol_BP PF01237.18 AAS54846.1 - 4.5e-105 351.5 0.5 3e-104 348.8 0.5 2.0 1 1 0 1 1 1 1 Oxysterol-binding protein PH_8 PF15409.6 AAS54846.1 - 2.6e-32 110.9 0.3 8.8e-32 109.2 0.3 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 AAS54846.1 - 5e-05 23.8 0.3 0.00016 22.1 0.3 2.0 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 AAS54846.1 - 0.0098 16.3 4.1 0.48 10.9 4.1 2.8 1 1 0 1 1 1 1 Pleckstrin homology domain Asparaginase PF00710.20 AAS54847.1 - 2.5e-55 187.0 0.0 5.3e-55 185.9 0.0 1.5 2 0 0 2 2 2 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 AAS54847.1 - 1.3e-18 67.3 0.0 3.2e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain PucR PF07905.11 AAS54847.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 Purine catabolism regulatory protein-like family CN_hydrolase PF00795.22 AAS54848.1 - 8.9e-43 146.5 0.0 1.2e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NAD_synthase PF02540.17 AAS54848.1 - 8e-24 84.1 0.0 2e-23 82.8 0.0 1.6 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 AAS54848.1 - 0.031 13.9 0.0 0.062 12.9 0.0 1.4 1 0 0 1 1 1 0 Asparagine synthase Abhydrolase_6 PF12697.7 AAS54849.1 - 8.9e-20 72.2 0.0 1.3e-19 71.7 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AAS54849.1 - 5.2e-11 42.7 0.0 8.5e-11 42.0 0.0 1.3 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AAS54849.1 - 1.1e-08 34.7 0.0 1.5e-08 34.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Lipase_3 PF01764.25 AAS54849.1 - 0.0038 17.1 0.0 0.007 16.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) VirJ PF06057.11 AAS54849.1 - 0.0085 16.0 0.0 0.071 13.0 0.0 2.0 2 0 0 2 2 2 1 Bacterial virulence protein (VirJ) PGAP1 PF07819.13 AAS54849.1 - 0.011 15.5 0.1 0.02 14.6 0.1 1.5 1 1 0 1 1 1 0 PGAP1-like protein Bep_C_terminal PF17841.1 AAS54849.1 - 0.012 15.8 0.1 0.23 11.7 0.0 2.9 3 1 1 4 4 4 0 BID domain of Bartonella effector protein (Bep) DUF2974 PF11187.8 AAS54849.1 - 0.016 14.8 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Cutinase PF01083.22 AAS54849.1 - 0.02 14.8 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Cutinase Thioesterase PF00975.20 AAS54849.1 - 0.045 13.9 0.1 0.23 11.6 0.1 2.1 1 1 0 1 1 1 0 Thioesterase domain DUF676 PF05057.14 AAS54849.1 - 0.054 13.0 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Putative serine esterase (DUF676) Abhydrolase_3 PF07859.13 AAS54849.1 - 0.057 13.3 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold LIDHydrolase PF10230.9 AAS54849.1 - 0.098 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Peptidase_M1 PF01433.20 AAS54850.1 - 2.3e-70 236.5 0.1 3.7e-70 235.9 0.1 1.3 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 AAS54850.1 - 7.8e-50 169.7 0.4 1.1e-48 165.9 0.0 2.6 3 0 0 3 3 3 1 Peptidase M1 N-terminal domain ERAP1_C PF11838.8 AAS54850.1 - 1.2e-44 153.1 0.0 2.3e-44 152.2 0.0 1.5 1 0 0 1 1 1 1 ERAP1-like C-terminal domain PBP PF01161.20 AAS54851.1 - 6.6e-05 23.2 0.1 0.00013 22.3 0.1 1.4 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein ATP-synt_E PF05680.12 AAS54852.1 - 6e-24 84.2 0.4 6.6e-24 84.1 0.4 1.0 1 0 0 1 1 1 1 ATP synthase E chain SpoIIE PF07228.12 AAS54853.1 - 5.3e-28 98.2 0.0 7.9e-28 97.7 0.0 1.3 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C PF00481.21 AAS54853.1 - 6.5e-08 32.5 0.0 0.0028 17.3 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 AAS54853.1 - 1.4e-05 24.9 0.1 2.8e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C DUF3558 PF12079.8 AAS54853.1 - 0.089 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3558) MIF4G PF02854.19 AAS54854.2 - 1.2e-29 103.4 33.0 1.3e-16 60.9 0.2 3.8 4 1 0 4 4 4 3 MIF4G domain Upf2 PF04050.14 AAS54854.2 - 3.2e-22 79.7 4.5 3.2e-22 79.7 4.5 2.8 2 1 1 3 3 3 1 Up-frameshift suppressor 2 Astro_capsid_p PF12226.8 AAS54854.2 - 0.58 9.3 16.5 0.46 9.6 14.3 1.9 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Mt_ATP-synt_D PF05873.12 AAS54854.2 - 0.72 9.7 8.1 0.03 14.2 1.1 2.2 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) GET2 PF08690.10 AAS54854.2 - 1.1 8.8 11.5 2.9 7.5 11.5 1.7 1 0 0 1 1 1 0 GET complex subunit GET2 Nop14 PF04147.12 AAS54854.2 - 7.8 4.6 32.3 0.53 8.4 24.2 2.4 2 0 0 2 2 2 0 Nop14-like family Rbsn PF11464.8 AAS54855.1 - 2e-18 65.8 4.0 7.3e-18 64.0 4.0 2.1 1 0 0 1 1 1 1 Rabenosyn Rab binding domain FYVE PF01363.21 AAS54855.1 - 5e-17 61.8 25.6 1.2e-15 57.4 2.8 3.1 3 0 0 3 3 3 2 FYVE zinc finger zf-Di19 PF05605.12 AAS54855.1 - 0.0058 16.9 0.4 0.048 13.9 0.1 2.7 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding FYVE_2 PF02318.16 AAS54855.1 - 0.0097 16.1 1.7 0.0097 16.1 1.7 3.1 2 0 0 2 2 2 1 FYVE-type zinc finger Rad50_zn_hook PF04423.14 AAS54855.1 - 0.015 15.1 10.2 0.24 11.3 0.0 3.9 4 0 0 4 4 4 0 Rad50 zinc hook motif DASH_Dad2 PF08654.10 AAS54855.1 - 0.099 13.1 2.6 4.3 7.8 1.4 3.1 3 0 0 3 3 3 0 DASH complex subunit Dad2 ABC_tran_CTD PF16326.5 AAS54855.1 - 0.12 12.6 1.8 3.6 7.9 0.6 3.4 3 1 0 3 3 3 0 ABC transporter C-terminal domain zf-C2H2 PF00096.26 AAS54855.1 - 2.7 8.6 0.0 2.7 8.6 0.0 5.0 4 1 1 5 5 3 0 Zinc finger, C2H2 type CorA PF01544.18 AAS54855.1 - 8.4 5.6 7.4 11 5.3 0.5 3.0 3 0 0 3 3 3 0 CorA-like Mg2+ transporter protein TSC22 PF01166.18 AAS54855.1 - 8.9 6.7 8.9 0.42 11.0 1.3 2.7 3 0 0 3 3 3 0 TSC-22/dip/bun family HypA PF01155.19 AAS54855.1 - 9.4 6.3 12.0 16 5.5 3.3 3.6 3 0 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA ABA_GPCR PF12430.8 AAS54856.1 - 3.6e-56 189.8 5.5 3.6e-56 189.8 5.5 3.0 3 1 0 3 3 3 1 Abscisic acid G-protein coupled receptor GPHR_N PF12537.8 AAS54856.1 - 1.3e-15 57.2 0.1 5.6e-15 55.2 0.1 2.2 1 0 0 1 1 1 1 The Golgi pH Regulator (GPHR) Family N-terminal WD40 PF00400.32 AAS54857.2 - 3.5e-11 43.4 19.1 1.2 10.2 0.1 9.2 8 2 1 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 AAS54857.2 - 2.9e-10 40.3 7.5 0.22 11.9 0.1 7.4 3 3 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 AAS54857.2 - 6.3e-05 21.9 1.6 3.2 6.4 0.0 4.2 2 1 1 4 4 4 4 Nup133 N terminal like Ge1_WD40 PF16529.5 AAS54857.2 - 0.0004 19.4 0.5 0.046 12.7 0.2 2.8 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein AhpC-TSA PF00578.21 AAS54858.2 - 3.3e-29 101.3 0.0 4.6e-29 100.9 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family 1-cysPrx_C PF10417.9 AAS54858.2 - 1.5e-13 50.4 0.0 2.4e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin Redoxin PF08534.10 AAS54858.2 - 8e-09 35.4 0.0 1.1e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin Fungal_trans PF04082.18 AAS54859.1 - 4.4e-18 65.3 4.5 7.9e-18 64.4 4.5 1.4 1 0 0 1 1 1 1 Fungal specific transcription factor domain Zn_clus PF00172.18 AAS54859.1 - 3.7e-09 36.5 9.9 5.9e-09 35.9 9.9 1.3 1 0 0 1 1 1 1 Fungal Zn(2)-Cys(6) binuclear cluster domain UCH PF00443.29 AAS54860.2 - 3.6e-62 210.2 0.0 5.2e-62 209.7 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS54860.2 - 9.2e-24 84.6 1.3 1.6e-16 60.8 0.1 2.4 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Pribosyltran_N PF13793.6 AAS54861.1 - 1.3e-44 150.8 0.2 6.9e-43 145.3 0.0 2.3 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 AAS54861.1 - 1.4e-36 126.3 2.1 4.1e-30 105.2 1.8 2.4 1 1 1 2 2 2 2 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 AAS54861.1 - 4.2e-16 58.9 0.2 1.1e-15 57.6 0.2 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AAS54861.1 - 0.0015 18.0 0.1 0.0025 17.3 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase UQ_con PF00179.26 AAS54862.1 - 2.3e-22 79.1 0.1 3.7e-22 78.5 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 AAS54862.1 - 0.009 15.7 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic E2 family B DUF5316 PF17247.2 AAS54862.1 - 0.047 13.7 0.0 1.8 8.6 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5316) ADH_zinc_N_2 PF13602.6 AAS54863.2 - 1.3e-14 55.4 0.0 2.6e-14 54.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AAS54863.2 - 2.4e-06 27.4 0.0 4.1e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AAS54863.2 - 0.026 14.5 0.0 0.15 12.1 0.0 2.2 2 1 0 2 2 2 0 Zinc-binding dehydrogenase zf-CSL PF05207.13 AAS54864.1 - 3.7e-22 77.8 1.9 4.7e-22 77.5 1.9 1.1 1 0 0 1 1 1 1 CSL zinc finger Ribosomal_S8e PF01201.22 AAS54865.1 - 1.1e-57 194.0 1.7 1.3e-57 193.8 1.7 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e AAR2 PF05282.11 AAS54866.2 - 2.5e-30 106.1 0.0 4.3e-30 105.3 0.0 1.3 1 1 0 1 1 1 1 AAR2 protein EMP24_GP25L PF01105.24 AAS54867.1 - 6.3e-06 26.3 0.0 1.5e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF5010_C PF18099.1 AAS54867.1 - 0.16 12.1 0.6 1.7 8.8 0.1 2.2 1 1 1 2 2 2 0 DUF5010 C-terminal domain Spc7 PF08317.11 AAS54868.1 - 0.03 13.2 2.0 0.034 13.0 2.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 AAS54868.1 - 0.066 12.8 1.1 0.076 12.6 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc24 PF08286.11 AAS54868.1 - 0.093 13.0 0.4 0.11 12.7 0.4 1.3 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 TBCA PF02970.16 AAS54868.1 - 0.094 13.1 3.2 1.7 9.1 2.2 2.1 1 1 1 2 2 2 0 Tubulin binding cofactor A SNF2_N PF00176.23 AAS54869.2 - 9.4e-68 228.5 0.4 9.4e-68 228.5 0.4 2.2 2 1 0 2 2 2 1 SNF2 family N-terminal domain DBINO PF13892.6 AAS54869.2 - 3.6e-48 163.3 20.5 3.6e-48 163.3 20.5 5.1 7 0 0 7 7 7 1 DNA-binding domain Helicase_C PF00271.31 AAS54869.2 - 3.1e-17 62.9 0.0 1.5e-16 60.8 0.0 2.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AAS54869.2 - 6.8e-07 29.4 0.1 6.2e-06 26.3 0.0 2.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 AAS54869.2 - 0.00011 21.5 0.4 0.00011 21.5 0.4 3.5 4 0 0 4 4 4 1 Class II histone deacetylase complex subunits 2 and 3 Fe_hyd_lg_C PF02906.14 AAS54869.2 - 0.0056 16.4 0.5 0.015 15.0 0.5 1.7 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain Pox_A12 PF04651.13 AAS54869.2 - 0.033 14.2 0.1 0.095 12.7 0.1 1.8 1 0 0 1 1 1 0 Poxvirus A12 protein Med5 PF08689.10 AAS54870.1 - 0 1355.3 22.4 0 1355.1 22.4 1.0 1 0 0 1 1 1 1 Mediator complex subunit Med5 PglZ PF08665.12 AAS54870.1 - 0.015 15.4 0.2 0.035 14.2 0.2 1.7 1 0 0 1 1 1 0 PglZ domain Pex14_N PF04695.13 AAS54871.1 - 1.6e-29 103.6 2.2 1.7e-26 93.7 2.2 2.8 1 1 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Myosin_tail_1 PF01576.19 AAS54871.1 - 0.0014 16.5 14.1 0.0019 16.1 14.1 1.1 1 0 0 1 1 1 1 Myosin tail DUF948 PF06103.11 AAS54871.1 - 0.0015 18.7 1.9 0.25 11.6 1.3 2.5 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 AAS54871.1 - 0.0039 16.6 0.9 0.0045 16.4 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF1043 PF06295.12 AAS54871.1 - 0.0057 16.7 11.1 0.06 13.4 10.6 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1043) COR PF16095.5 AAS54871.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 C-terminal of Roc, COR, domain zf-C4H2 PF10146.9 AAS54871.1 - 0.03 14.6 3.8 0.046 14.0 3.8 1.2 1 0 0 1 1 1 0 Zinc finger-containing protein Spc7 PF08317.11 AAS54871.1 - 0.04 12.8 13.3 0.061 12.2 13.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein YPEB PF14620.6 AAS54871.1 - 0.041 13.2 1.7 0.059 12.7 1.7 1.3 1 0 0 1 1 1 0 YpeB sporulation BST2 PF16716.5 AAS54871.1 - 0.079 13.6 8.8 0.064 13.9 6.7 1.9 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Exonuc_VII_L PF02601.15 AAS54871.1 - 0.087 12.4 3.3 0.14 11.7 3.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 AAS54871.1 - 0.096 12.7 3.4 0.13 12.3 1.0 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus ECH_2 PF16113.5 AAS54871.1 - 0.096 12.2 1.8 0.17 11.3 1.5 1.5 1 1 0 1 1 1 0 Enoyl-CoA hydratase/isomerase FapA PF03961.13 AAS54871.1 - 0.13 10.8 8.8 0.16 10.6 7.7 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Laminin_II PF06009.12 AAS54871.1 - 0.14 12.2 7.8 0.3 11.1 7.8 1.6 1 0 0 1 1 1 0 Laminin Domain II DUF1664 PF07889.12 AAS54871.1 - 0.15 12.1 5.0 0.94 9.5 4.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CCDC-167 PF15188.6 AAS54871.1 - 0.28 11.6 10.4 0.11 12.8 1.7 2.6 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Prominin PF05478.11 AAS54871.1 - 0.3 9.0 2.0 0.38 8.6 2.0 1.1 1 0 0 1 1 1 0 Prominin LMBR1 PF04791.16 AAS54871.1 - 0.33 9.8 0.7 0.43 9.4 0.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein SF-assemblin PF06705.11 AAS54871.1 - 0.33 10.2 11.4 0.51 9.6 11.4 1.2 1 0 0 1 1 1 0 SF-assemblin/beta giardin Seryl_tRNA_N PF02403.22 AAS54871.1 - 0.33 11.2 11.2 0.99 9.7 11.1 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 AAS54871.1 - 0.61 9.9 11.9 0.53 10.1 1.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF724) GTP-bdg_M PF16360.5 AAS54871.1 - 0.73 10.5 9.0 0.71 10.5 1.8 3.2 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region HIP1_clath_bdg PF16515.5 AAS54871.1 - 0.87 10.2 16.2 0.83 10.3 9.4 2.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 V_ATPase_I PF01496.19 AAS54871.1 - 1 7.2 4.5 1.4 6.7 4.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LXG PF04740.12 AAS54871.1 - 1.3 8.7 12.3 0.26 11.0 3.1 2.5 2 1 1 3 3 2 0 LXG domain of WXG superfamily Prefoldin_2 PF01920.20 AAS54871.1 - 1.5 8.8 15.8 0.47 10.4 5.3 3.3 1 1 2 3 3 3 0 Prefoldin subunit APG6_N PF17675.1 AAS54871.1 - 1.7 9.1 18.7 5.8 7.5 18.7 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region Goodbye PF17109.5 AAS54871.1 - 2.4 8.6 5.0 2.2 8.8 1.2 2.2 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain TMPIT PF07851.13 AAS54871.1 - 2.6 7.2 9.0 1.6 7.9 6.7 1.6 1 1 1 2 2 2 0 TMPIT-like protein Phage_GPO PF05929.11 AAS54871.1 - 2.9 7.4 8.0 5.4 6.6 8.0 1.4 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DHR10 PF18595.1 AAS54871.1 - 3.5 7.7 16.5 32 4.6 12.9 2.5 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain CENP-H PF05837.12 AAS54871.1 - 3.9 7.9 12.5 0.83 10.1 5.7 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Nup88 PF10168.9 AAS54871.1 - 4.1 5.1 10.9 5.7 4.6 10.9 1.1 1 0 0 1 1 1 0 Nuclear pore component Occludin_ELL PF07303.13 AAS54871.1 - 4.9 7.9 10.0 1.1e+02 3.6 10.0 2.3 1 1 0 1 1 1 0 Occludin homology domain Allexi_40kDa PF05549.11 AAS54871.1 - 7.3 6.0 6.7 4.4 6.7 2.9 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein ACPS PF01648.20 AAS54872.2 - 9.5e-09 35.4 0.0 1.4e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Mito_carr PF00153.27 AAS54873.1 - 7.2e-49 163.7 1.2 1.8e-18 66.2 0.0 3.4 3 1 0 3 3 3 3 Mitochondrial carrier protein Prenyltrans PF00432.21 AAS54874.1 - 2.7e-21 75.0 14.5 2.8e-05 23.7 0.1 5.1 5 0 0 5 5 5 4 Prenyltransferase and squalene oxidase repeat Glyco_hydro_38N PF01074.22 AAS54875.2 - 7.6e-79 265.1 1.1 1.5e-78 264.1 1.1 1.5 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro_38C PF07748.13 AAS54875.2 - 1.8e-46 158.9 2.1 2e-46 158.8 1.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 AAS54875.2 - 3.8e-24 84.7 0.0 8e-24 83.6 0.0 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro38C2 PF17677.1 AAS54875.2 - 1.8e-07 31.2 0.1 6.5e-07 29.4 0.1 2.0 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Inhibitor_I9 PF05922.16 AAS54876.1 - 0.00079 20.0 0.1 0.064 13.9 0.1 2.1 1 1 0 1 1 1 1 Peptidase inhibitor I9 DUF4230 PF14014.6 AAS54876.1 - 0.064 13.5 0.1 0.066 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) Frataxin_Cyay PF01491.16 AAS54877.2 - 6.3e-37 126.0 0.0 7e-37 125.8 0.0 1.0 1 0 0 1 1 1 1 Frataxin-like domain CPSase_sm_chain PF00988.22 AAS54877.2 - 0.056 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain DDE_5 PF13546.6 AAS54877.2 - 0.15 11.4 0.0 0.19 11.1 0.0 1.1 1 0 0 1 1 1 0 DDE superfamily endonuclease TMEM132D_C PF15706.5 AAS54878.1 - 0.099 12.4 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term UCH PF00443.29 AAS54879.1 - 1.3e-43 149.4 0.0 4.8e-43 147.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 AAS54879.1 - 1.9e-06 27.7 0.1 0.059 13.0 0.1 3.8 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase COG2 PF06148.11 AAS54879.1 - 0.19 11.8 0.5 0.61 10.2 0.5 1.8 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_1 PF00076.22 AAS54880.1 - 5.3e-52 173.5 1.5 6.5e-18 64.3 0.0 3.2 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 AAS54880.1 - 2.5e-09 36.9 0.0 0.0045 16.8 0.0 3.1 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_5 PF13893.6 AAS54880.1 - 7.5e-05 22.3 0.0 0.006 16.2 0.0 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 AAS54880.1 - 0.00087 19.4 0.3 0.081 13.1 0.1 3.5 3 1 1 4 4 4 1 RNA recognition motif PHM7_cyt PF14703.6 AAS54880.1 - 0.0064 16.7 0.9 4.6 7.4 0.0 2.8 3 0 0 3 3 3 2 Cytosolic domain of 10TM putative phosphate transporter Nup35_RRM_2 PF14605.6 AAS54880.1 - 0.014 15.4 0.2 0.3 11.1 0.0 2.6 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 AAS54880.1 - 0.074 13.1 0.2 4 7.5 0.0 2.5 2 0 0 2 2 2 0 RNA binding motif DFP PF04127.15 AAS54881.2 - 2.9e-18 66.4 0.1 6.5e-09 35.9 0.0 2.5 3 0 0 3 3 3 2 DNA / pantothenate metabolism flavoprotein Peptidase_A2B PF12384.8 AAS54881.2 - 0.16 11.5 0.0 0.71 9.4 0.0 1.9 2 0 0 2 2 2 0 Ty3 transposon peptidase Bac_surface_Ag PF01103.23 AAS54882.1 - 1e-41 143.6 0.2 9.8e-41 140.3 0.2 2.1 1 1 0 1 1 1 1 Surface antigen Maf PF02545.14 AAS54882.1 - 0.0035 17.2 0.0 0.0057 16.5 0.0 1.2 1 0 0 1 1 1 1 Maf-like protein DUF3947 PF13135.6 AAS54882.1 - 0.04 14.1 0.1 0.09 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) DnaJ PF00226.31 AAS54883.1 - 0.0098 16.0 0.0 0.018 15.2 0.0 1.4 1 0 0 1 1 1 1 DnaJ domain AAA PF00004.29 AAS54884.1 - 1e-54 184.5 0.0 4e-44 150.2 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AAS54884.1 - 6.6e-10 38.6 0.7 0.00013 21.7 0.0 3.0 3 1 0 3 3 2 2 AAA+ lid domain AAA_16 PF13191.6 AAS54884.1 - 1.9e-06 28.4 0.0 0.02 15.3 0.0 3.8 3 0 0 3 3 3 1 AAA ATPase domain TsaE PF02367.17 AAS54884.1 - 3.1e-05 23.9 0.1 0.24 11.4 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RuvB_N PF05496.12 AAS54884.1 - 0.00041 20.1 0.0 0.002 17.9 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 AAS54884.1 - 0.00044 20.4 0.0 0.2 11.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 AAS54884.1 - 0.0022 18.2 0.0 0.0059 16.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 AAS54884.1 - 0.0022 18.4 0.0 0.037 14.4 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 AAS54884.1 - 0.0024 18.2 0.0 0.026 14.8 0.0 2.7 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 AAS54884.1 - 0.0025 17.3 0.1 0.027 14.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Parvo_NS1 PF01057.17 AAS54884.1 - 0.0025 16.9 0.0 0.0055 15.8 0.0 1.5 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 AAA_14 PF13173.6 AAS54884.1 - 0.0041 17.2 0.0 0.83 9.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 AAS54884.1 - 0.0084 15.3 0.0 0.05 12.8 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 AAS54884.1 - 0.014 15.1 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 AAS54884.1 - 0.015 15.3 0.0 0.089 12.8 0.0 2.4 2 1 0 2 2 1 0 AAA domain (dynein-related subfamily) ATPase PF06745.13 AAS54884.1 - 0.019 14.3 0.0 0.037 13.4 0.0 1.4 1 0 0 1 1 1 0 KaiC Mg_chelatase PF01078.21 AAS54884.1 - 0.02 14.2 0.1 0.042 13.2 0.1 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Vps4_C PF09336.10 AAS54884.1 - 0.039 13.9 0.0 0.16 11.9 0.0 2.0 2 0 0 2 2 1 0 Vps4 C terminal oligomerisation domain AAA_18 PF13238.6 AAS54884.1 - 0.047 14.2 0.0 0.21 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 AAS54884.1 - 0.055 13.7 0.0 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 AAS54884.1 - 0.1 12.1 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Cobl PF09469.10 AAS54884.1 - 0.13 12.6 0.0 9.3 6.6 0.0 2.7 2 0 0 2 2 2 0 Cordon-bleu ubiquitin-like domain AAA_25 PF13481.6 AAS54884.1 - 0.14 11.7 0.4 1.4 8.4 0.1 2.5 2 1 1 3 3 3 0 AAA domain Hist_deacetyl PF00850.19 AAS54885.1 - 8.1e-84 281.7 0.1 1.7e-83 280.7 0.0 1.5 2 0 0 2 2 2 1 Histone deacetylase domain DMRL_synthase PF00885.19 AAS54886.2 - 7.3e-53 178.2 0.1 8.7e-53 177.9 0.1 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase RRM_1 PF00076.22 AAS54887.2 - 0.00057 19.6 0.0 0.0014 18.4 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.17 AAS54888.1 - 4.3e-28 95.1 22.4 0.00024 21.0 0.3 11.5 11 0 0 11 11 11 7 Tetratricopeptide repeat TPR_1 PF00515.28 AAS54888.1 - 2e-22 78.0 29.1 0.0019 18.0 0.0 11.7 11 0 0 11 11 11 6 Tetratricopeptide repeat TPR_12 PF13424.6 AAS54888.1 - 1.5e-17 63.7 18.1 0.0027 18.0 0.0 8.9 8 2 1 9 9 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 AAS54888.1 - 7.4e-14 52.1 7.9 0.00016 22.2 0.0 6.7 6 1 2 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 AAS54888.1 - 4.4e-11 42.6 20.2 0.0037 17.9 0.1 10.6 11 2 2 13 13 9 2 Tetratricopeptide repeat TPR_19 PF14559.6 AAS54888.1 - 4.5e-11 43.1 27.8 0.00063 20.2 0.2 8.6 9 1 1 10 10 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 AAS54888.1 - 4.9e-11 41.9 22.2 0.77 10.1 0.0 11.7 12 0 0 12 12 12 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AAS54888.1 - 1.1e-08 35.2 9.5 0.00028 21.0 0.1 5.1 5 0 0 5 5 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 AAS54888.1 - 1.1e-06 28.9 22.5 1.4 9.7 0.7 9.9 10 0 0 10 10 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 AAS54888.1 - 2.7e-06 27.0 19.2 0.0091 15.7 1.2 8.1 9 2 1 10 10 10 2 TPR repeat TPR_17 PF13431.6 AAS54888.1 - 4.4e-06 26.7 9.8 5.3 7.7 0.0 9.1 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_10 PF13374.6 AAS54888.1 - 9.5e-05 22.1 12.2 0.67 9.9 0.5 7.6 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 AAS54888.1 - 0.00064 19.6 24.4 3.1 8.0 0.3 9.1 10 0 0 10 10 10 2 Tetratricopeptide repeat PPR PF01535.20 AAS54888.1 - 0.013 15.7 1.3 1e+02 3.5 0.0 5.5 6 0 0 6 6 5 0 PPR repeat TPR_3 PF07720.12 AAS54888.1 - 0.07 13.2 0.1 0.07 13.2 0.1 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 AAS54888.1 - 0.13 12.5 5.7 3 8.1 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR_2 PF13041.6 AAS54888.1 - 0.33 11.2 1.7 1.2e+02 3.0 0.1 4.2 4 0 0 4 4 4 0 PPR repeat family DUF1027 PF06265.11 AAS54888.1 - 0.7 9.9 3.6 34 4.5 0.1 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1027) Sld5 PF05916.11 AAS54889.1 - 2.9e-15 56.6 0.0 3.7e-15 56.3 0.0 1.1 1 0 0 1 1 1 1 GINS complex protein PEX11 PF05648.14 AAS54890.1 - 8.6e-64 215.0 1.5 9.8e-64 214.9 1.5 1.0 1 0 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) Spt20 PF12090.8 AAS54891.1 - 2.3e-63 213.9 0.0 2.3e-63 213.9 0.0 3.1 3 0 0 3 3 3 1 Spt20 family DCP1 PF06058.13 AAS54892.1 - 6.7e-28 97.0 0.1 7.9e-27 93.5 0.1 2.3 1 1 0 1 1 1 1 Dcp1-like decapping family Hydrolase_2 PF07486.12 AAS54892.1 - 0.049 14.5 0.1 3.6 8.5 0.0 2.1 2 0 0 2 2 2 0 Cell Wall Hydrolase GFO_IDH_MocA PF01408.22 AAS54893.1 - 2.8e-22 79.8 1.1 7e-22 78.5 1.1 1.7 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 AAS54893.1 - 4.1e-10 39.7 0.0 9.2e-10 38.5 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain Shikimate_DH PF01488.20 AAS54893.1 - 0.0023 18.0 0.3 0.025 14.7 0.2 2.6 3 1 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase NAD_binding_3 PF03447.16 AAS54893.1 - 0.023 15.3 1.2 0.045 14.4 1.2 1.6 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AAS54893.1 - 0.066 13.8 1.1 0.25 12.0 0.2 2.5 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_M3 PF01432.20 AAS54895.2 - 1e-133 447.0 0.1 1.5e-133 446.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3 PF01432.20 AAS54896.1 - 9.5e-134 447.1 0.0 1.2e-133 446.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M3 Asp PF00026.23 AAS54897.2 - 7.8e-82 275.2 0.0 9.2e-82 275.0 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 AAS54897.2 - 5.6e-10 39.7 0.4 4.9e-06 26.9 0.2 3.7 2 2 2 4 4 4 2 Xylanase inhibitor N-terminal TAXi_C PF14541.6 AAS54897.2 - 1.3e-07 31.5 0.0 5.1e-06 26.4 0.0 2.3 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Asp_protease_2 PF13650.6 AAS54897.2 - 0.03 15.0 0.0 0.14 12.8 0.0 2.2 2 0 0 2 2 2 0 Aspartyl protease gag-asp_proteas PF13975.6 AAS54897.2 - 0.11 13.0 0.0 1.6 9.4 0.0 2.7 3 1 0 3 3 3 0 gag-polyprotein putative aspartyl protease TcdA_TcdB_pore PF12920.7 ABL67640.1 - 2.9 6.0 5.5 2.6 6.2 5.5 1.1 1 0 0 1 1 1 0 TcdA/TcdB pore forming domain PqqD PF05402.12 ADJ41735.1 - 0.042 14.1 0.1 0.057 13.7 0.1 1.2 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) CYSTM PF12734.7 ADJ41736.1 - 0.00011 22.5 11.8 0.00011 22.5 11.8 2.3 2 0 0 2 2 2 1 Cysteine-rich TM module stress tolerance Keratin_2_head PF16208.5 ADJ41736.1 - 0.98 9.5 23.3 1.2 9.3 23.3 1.1 1 0 0 1 1 1 0 Keratin type II head DUF5320 PF17253.2 ADJ41736.1 - 4.6 8.4 19.9 6.7 7.8 19.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Cyt-b5 PF00173.28 ADJ41737.1 - 2.5e-12 46.7 0.0 3.9e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain HMG_box PF00505.19 ADJ41738.1 - 1.6e-34 118.1 13.3 2.5e-18 66.2 5.4 2.3 2 0 0 2 2 2 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ADJ41738.1 - 4.3e-21 75.3 9.9 2.7e-11 43.9 4.8 2.4 2 0 0 2 2 2 2 HMG-box domain CHDNT PF08073.12 ADJ41738.1 - 5.3e-08 32.7 0.0 0.0093 15.9 0.0 2.5 2 0 0 2 2 2 2 CHDNT (NUC034) domain MlaC PF05494.12 ADJ41738.1 - 0.00056 19.7 0.2 0.18 11.6 0.0 2.3 2 0 0 2 2 2 2 MlaC protein COX4 PF02936.14 ADJ41738.1 - 0.46 10.5 5.3 2.1 8.4 1.2 2.3 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV zinc_ribbon_6 PF14599.6 ADJ41739.1 - 3.9e-24 84.4 0.2 3.9e-24 84.4 0.2 3.2 3 1 0 3 3 3 1 Zinc-ribbon zf-CHY PF05495.12 ADJ41739.1 - 1.9e-16 60.3 16.5 1.9e-16 60.3 16.5 3.7 2 1 1 3 3 3 1 CHY zinc finger zf-RING_2 PF13639.6 ADJ41739.1 - 7.4e-09 35.8 9.1 7.4e-09 35.8 9.1 5.3 4 2 1 5 5 5 1 Ring finger domain zf-RING_UBOX PF13445.6 ADJ41739.1 - 4.7e-05 23.3 6.1 4.7e-05 23.3 6.1 3.8 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ADJ41739.1 - 0.00054 19.7 10.7 0.00054 19.7 10.7 4.8 5 2 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ADJ41739.1 - 0.0013 18.7 10.5 0.0013 18.7 10.5 5.9 3 3 3 6 6 6 1 zinc-RING finger domain Mito_fiss_reg PF05308.11 ADJ41739.1 - 0.089 12.9 0.4 0.17 12.0 0.4 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator SAVED PF18145.1 ADJ41739.1 - 0.12 12.1 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 SMODS-associated and fused to various effectors sensor domain CAP_N PF01213.19 ADJ41739.1 - 0.38 10.2 9.6 0.85 9.0 9.6 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Acetyltransf_1 PF00583.25 ADJ41740.1 - 2.3e-14 53.6 0.0 3e-14 53.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ADJ41740.1 - 2.4e-07 30.8 0.0 3.3e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ADJ41740.1 - 1.9e-06 28.2 0.0 3e-06 27.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ADJ41740.1 - 1.4e-05 25.0 0.1 3.8e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_CG PF14542.6 ADJ41740.1 - 0.0097 16.0 0.0 0.016 15.3 0.0 1.3 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_3 PF13302.7 ADJ41740.1 - 0.014 16.1 0.0 0.016 15.9 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ADJ41740.1 - 0.041 13.9 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Acetyltransf_4 PF13420.7 ADJ41740.1 - 0.066 13.4 0.0 0.091 12.9 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain B12D PF06522.11 ADJ41741.1 - 9.9e-05 22.1 0.0 0.00013 21.7 0.0 1.2 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit SKG6 PF08693.10 ADJ41743.1 - 0.0002 20.7 0.9 0.00026 20.3 0.9 1.2 1 0 0 1 1 1 1 Transmembrane alpha-helix domain TMEM154 PF15102.6 ADJ41743.1 - 0.19 11.6 0.0 0.23 11.4 0.0 1.1 1 0 0 1 1 1 0 TMEM154 protein family ADIP PF11559.8 ADJ41744.1 - 0.0059 16.7 3.0 0.028 14.5 0.0 2.7 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding 3-PAP PF12578.8 ADJ41744.1 - 0.012 15.3 0.2 2.9 7.6 0.1 3.1 3 0 0 3 3 3 0 Myotubularin-associated protein SlyX PF04102.12 ADJ41744.1 - 0.095 13.3 6.6 1.5 9.5 0.0 3.3 3 0 0 3 3 3 0 SlyX DUF2457 PF10446.9 ADJ41744.1 - 0.12 11.5 11.8 0.15 11.2 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ATG16 PF08614.11 ADJ41744.1 - 3.7 7.7 9.7 0.66 10.2 5.5 1.9 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HSP20 PF00011.21 ADJ41746.1 - 2.4e-21 75.8 0.4 3.5e-21 75.3 0.4 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ADJ41746.1 - 1.6e-06 27.6 0.0 2.4e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA BON PF04972.17 ADJ41746.1 - 0.037 14.3 0.1 3.2 8.1 0.1 2.4 2 0 0 2 2 2 0 BON domain Transpos_assoc PF13963.6 ADJ41747.1 - 0.069 13.5 0.1 0.086 13.2 0.1 1.1 1 0 0 1 1 1 0 Transposase-associated domain COX7C PF02935.16 ADJ41748.1 - 0.0035 17.5 0.8 0.0069 16.6 0.8 1.6 1 1 0 1 1 1 1 Cytochrome c oxidase subunit VIIc DUF5137 PF17220.3 ADJ41750.1 - 2e-14 54.2 0.3 2.3e-14 54.0 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF5137) MT0933_antitox PF14013.6 ADJ41753.1 - 0.26 11.6 5.8 1.2 9.5 6.2 1.8 1 1 1 2 2 2 0 MT0933-like antitoxin protein DPM2 PF07297.12 ADJ41754.1 - 6e-11 42.5 1.3 6.5e-11 42.4 1.3 1.0 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) LapA_dom PF06305.11 ADJ41754.1 - 2.5 8.0 5.5 0.26 11.1 1.1 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain AAA_32 PF13654.6 ADJ41755.1 - 0.057 12.2 0.0 0.06 12.1 0.0 1.1 1 0 0 1 1 1 0 AAA domain Cellsynth_D PF03500.13 ADJ41755.1 - 0.062 13.2 0.0 0.075 12.9 0.0 1.1 1 0 0 1 1 1 0 Cellulose synthase subunit D HLH PF00010.26 ADJ41755.1 - 0.13 12.2 0.0 0.17 11.9 0.0 1.1 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Pyrid_oxidase_2 PF13883.6 ADJ41757.1 - 1.2e-22 80.6 0.0 1.9e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ADJ41757.1 - 0.0052 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 ADJ41758.1 - 2.3e-16 60.2 0.0 3.5e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Rtf2 PF04641.12 ADJ41760.1 - 5.9e-31 107.8 0.0 4.4e-30 104.9 0.0 1.9 1 1 0 1 1 1 1 Rtf2 RING-finger Glyco_transf_15 PF01793.16 ADJ41761.1 - 8.5e-127 422.9 11.5 1.1e-126 422.6 11.5 1.1 1 0 0 1 1 1 1 Glycolipid 2-alpha-mannosyltransferase DNA_pol_alpha_N PF12254.8 ADJ41761.1 - 0.11 12.6 0.0 7.5 6.7 0.0 2.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit p180 N terminal zf-C2H2 PF00096.26 ADJ41763.1 - 2.1e-09 37.3 7.4 0.00027 21.2 0.3 2.3 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ADJ41763.1 - 1.4e-07 31.7 6.6 0.0046 17.7 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ADJ41763.1 - 1.5e-05 25.2 15.7 0.0079 16.6 0.6 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-met PF12874.7 ADJ41763.1 - 9.7e-05 22.6 6.2 0.0015 18.9 0.2 2.4 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2HC_2 PF13913.6 ADJ41763.1 - 0.0036 17.1 1.7 0.29 11.1 0.0 2.5 2 0 0 2 2 2 1 zinc-finger of a C2HC-type FOXP-CC PF16159.5 ADJ41763.1 - 0.005 17.4 0.4 0.005 17.4 0.4 1.5 2 0 0 2 2 2 1 FOXP coiled-coil domain Zn-C2H2_12 PF18112.1 ADJ41763.1 - 0.0056 17.1 1.3 0.015 15.8 0.1 2.1 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain zf-C2H2_9 PF16293.5 ADJ41763.1 - 0.08 12.8 1.0 0.54 10.1 0.2 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (1 copy) DUF2256 PF10013.9 ADJ41763.1 - 0.52 10.5 2.9 0.33 11.1 0.5 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-Di19 PF05605.12 ADJ41763.1 - 0.58 10.5 7.6 27 5.2 1.3 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ADJ41763.1 - 1.1 9.4 7.0 1.6 8.8 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ADJ41763.1 - 2.4 8.5 9.3 1.9 8.9 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding CYSTM PF12734.7 ADJ41764.1 - 0.00048 20.4 34.8 0.014 15.7 34.8 2.6 1 1 0 1 1 1 1 Cysteine-rich TM module stress tolerance Sipho_Gp157 PF05565.11 ADJ41765.1 - 0.0063 16.5 1.8 0.0064 16.5 1.8 1.0 1 0 0 1 1 1 1 Siphovirus Gp157 Colicin_immun PF09204.10 ADJ41765.1 - 0.012 16.1 0.2 0.015 15.8 0.2 1.0 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity BLOC1_2 PF10046.9 ADJ41765.1 - 0.016 15.5 1.1 0.018 15.3 1.1 1.1 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spectrin PF00435.21 ADJ41765.1 - 0.026 15.0 0.5 0.031 14.8 0.5 1.1 1 0 0 1 1 1 0 Spectrin repeat DUF2951 PF11166.8 ADJ41765.1 - 0.027 14.7 0.8 0.034 14.3 0.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF4349 PF14257.6 ADJ41765.1 - 0.066 12.7 0.5 0.072 12.5 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) HTH_57 PF18679.1 ADJ41765.1 - 0.088 13.1 0.3 0.1 12.9 0.3 1.2 1 0 0 1 1 1 0 ThcOx helix turn helix domain cwf18 PF08315.12 ADJ41768.1 - 0.027 15.1 5.3 2.4 8.9 1.2 2.3 2 1 0 2 2 2 0 cwf18 pre-mRNA splicing factor RR_TM4-6 PF06459.12 ADJ41769.1 - 0.076 12.8 7.5 0.084 12.7 7.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 HSCB_C PF07743.13 ADJ41769.1 - 0.17 12.4 3.0 0.34 11.4 3.0 1.5 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain Spore_coat_CotO PF14153.6 ADJ41769.1 - 1.5 8.7 10.7 1.6 8.6 10.7 1.1 1 0 0 1 1 1 0 Spore coat protein CotO ASFV_J13L PF05568.11 ADJ41769.1 - 5.9 6.6 9.6 7.4 6.3 9.6 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein CPSF_A PF03178.15 ADJ41773.1 - 0.00048 19.5 0.0 0.002 17.5 0.0 2.0 2 0 0 2 2 2 1 CPSF A subunit region Herpes_teg_N PF04843.12 ADJ41773.1 - 0.043 13.5 0.1 0.25 11.0 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus tegument protein, N-terminal conserved region PMP1_2 PF08114.11 ADJ41774.1 - 0.00035 20.3 2.7 0.00037 20.2 2.7 1.2 1 0 0 1 1 1 1 ATPase proteolipid family VPDSG-CTERM PF18205.1 ADJ41774.1 - 0.27 11.1 4.0 0.17 11.7 2.1 1.6 1 1 1 2 2 2 0 VPDSG-CTERM motif Phage_int_SAM_1 PF02899.17 ADJ41775.1 - 0.16 12.3 0.1 0.72 10.2 0.0 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain TPR_MLP1_2 PF07926.12 ADJ41777.1 - 0.11 12.5 20.2 0.081 13.0 14.8 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SOGA PF11365.8 ADJ41777.1 - 0.81 10.9 0.1 0.81 10.9 0.1 3.3 4 0 0 4 4 4 0 Protein SOGA ABC_tran_CTD PF16326.5 ADJ41777.1 - 1.1 9.5 17.7 0.37 11.1 12.8 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain Tho2 PF11262.8 ADJ41777.1 - 2.5 7.2 8.1 0.51 9.5 4.3 1.7 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Phage_Mu_Gam PF07352.12 ADJ41777.1 - 3.2 7.6 10.8 6.7 6.6 9.1 2.3 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein Gly_acyl_tr_N PF06021.11 ADJ41777.1 - 6 6.9 7.2 0.47 10.5 1.2 2.0 3 0 0 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase HAUS-augmin3 PF14932.6 ADJ41779.1 - 0.0022 17.6 5.5 0.0022 17.6 5.5 1.8 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 3 RPN6_N PF18055.1 ADJ41779.1 - 0.023 15.1 3.1 0.045 14.1 3.1 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN6 N-terminal domain Trimer_CC PF08954.11 ADJ41779.1 - 0.056 13.0 0.1 0.17 11.5 0.1 1.8 1 0 0 1 1 1 0 Trimerisation motif Troponin PF00992.20 ADJ41779.1 - 0.088 13.1 11.0 0.079 13.3 9.2 1.8 2 0 0 2 2 2 0 Troponin DUF4250 PF14056.6 ADJ41779.1 - 0.1 12.6 0.7 1.9 8.5 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF4201 PF13870.6 ADJ41779.1 - 0.32 10.7 15.1 2 8.1 13.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) BRE1 PF08647.11 ADJ41779.1 - 0.85 9.7 16.3 0.042 13.9 5.5 3.0 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase PRKG1_interact PF15898.5 ADJ41779.1 - 1.4 9.9 14.3 2.9 8.9 10.8 2.5 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain ATG16 PF08614.11 ADJ41779.1 - 3.5 7.8 16.3 7.9 6.7 11.2 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) YabA PF06156.13 ADJ41779.1 - 6.4 7.5 10.3 21 5.8 2.9 3.0 1 1 2 3 3 3 0 Initiation control protein YabA LMBR1 PF04791.16 ADJ41780.1 - 8.5e-32 110.7 18.0 1.6e-31 109.8 18.0 1.4 1 1 0 1 1 1 1 LMBR1-like membrane protein Antigen_Bd37 PF11641.8 ADJ41780.1 - 0.12 11.9 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Glycosylphosphatidylinositol-anchored merozoite surface protein PhoR PF11808.8 ADJ41781.1 - 0.14 12.6 0.0 0.14 12.6 0.0 2.5 2 1 0 2 2 2 0 Phosphate regulon sensor protein PhoR Otopetrin PF03189.13 ADJ41786.1 - 0.25 10.1 0.0 0.26 10.1 0.0 1.1 1 0 0 1 1 1 0 Otopetrin Sec3_C PF09763.9 ADJ41787.1 - 0.24 9.8 0.0 0.35 9.2 0.0 1.1 1 0 0 1 1 1 0 Exocyst complex component Sec3 Methyltransf_30 PF05430.11 ADJ41789.1 - 0.04 13.8 0.0 0.041 13.8 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl-L-methionine-dependent methyltransferase Torus PF16131.5 ADJ41790.1 - 1.3e-33 115.9 0.0 3e-33 114.8 0.0 1.6 1 0 0 1 1 1 1 Torus domain RRM_1 PF00076.22 ADJ41790.1 - 3.1e-06 26.9 1.6 3.4e-06 26.8 0.1 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Neugrin PF06413.11 ADJ41790.1 - 0.0025 17.9 0.7 0.0038 17.3 0.7 1.2 1 0 0 1 1 1 1 Neugrin RRM_3 PF08777.11 ADJ41790.1 - 0.012 15.6 2.6 0.57 10.3 0.0 2.8 2 1 0 2 2 2 0 RNA binding motif PAP_RNA-bind PF04926.15 ADJ41790.1 - 0.058 13.0 0.2 0.11 12.2 0.2 1.5 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain zf-CCCH_4 PF18044.1 ADJ41790.1 - 0.17 11.7 7.6 0.34 10.7 7.6 1.5 1 0 0 1 1 1 0 CCCH-type zinc finger WBP-1 PF11669.8 ADJ41791.1 - 0.18 12.5 1.8 0.23 12.1 1.8 1.2 1 0 0 1 1 1 0 WW domain-binding protein 1 AGA2 PF17366.2 ADJ41792.1 - 8.2e-21 73.5 0.8 8.2e-21 73.5 0.8 3.3 3 0 0 3 3 3 1 A-agglutinin-binding subunit Aga2 PSY3 PF16836.5 ADJ41793.1 - 5.6e-54 182.9 0.0 6.6e-54 182.7 0.0 1.0 1 0 0 1 1 1 1 Shu complex component Psy3, DNA-binding description Sec10 PF07393.11 ADJ41795.1 - 4.2e-32 111.4 0.0 4.5e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 PaaX_C PF08223.11 ADJ41797.1 - 0.063 13.6 0.1 0.091 13.0 0.1 1.3 1 0 0 1 1 1 0 PaaX-like protein C-terminal domain Arnt_C PF18583.1 ADJ41797.1 - 0.14 11.8 0.3 0.24 11.0 0.3 1.4 1 0 0 1 1 1 0 Aminoarabinose transferase C-terminal domain Homeodomain PF00046.29 ADJ41798.1 - 5.2e-16 58.2 2.4 6.8e-16 57.9 2.4 1.2 1 0 0 1 1 1 1 Homeodomain Homeobox_KN PF05920.11 ADJ41798.1 - 4.5e-06 26.5 0.3 8.9e-06 25.5 0.3 1.5 1 0 0 1 1 1 1 Homeobox KN domain YdaS_antitoxin PF15943.5 ADJ41798.1 - 0.058 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT SUI1 PF01253.22 ADJ41799.1 - 2.8e-26 91.8 0.1 3.6e-26 91.5 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF2575 PF10837.8 ADJ41799.1 - 0.15 12.3 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2575) Pyrid_oxidase_2 PF13883.6 ADJ41800.1 - 2.3e-16 60.2 0.0 3.5e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 ADJ41801.1 - 1.2e-22 80.6 0.0 1.9e-22 80.1 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 ADJ41801.1 - 0.0052 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase OPT PF03169.15 ADJ41803.1 - 6.5e-143 477.6 40.4 7.5e-143 477.4 40.4 1.0 1 0 0 1 1 1 1 OPT oligopeptide transporter protein DUF4064 PF13273.6 ADJ41803.1 - 0.0086 16.3 0.2 0.0086 16.3 0.2 3.9 3 0 0 3 3 3 1 Protein of unknown function (DUF4064) DUF4191 PF13829.6 ADJ41803.1 - 0.33 10.3 0.9 1.1 8.5 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF983 PF06170.12 ADJ41803.1 - 3.1 8.3 13.9 0.086 13.3 5.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF983) DUF2427 PF10348.9 ADJ41804.1 - 0.11 12.2 10.3 0.35 10.7 10.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF2427) # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_gossypii_ATCC_10895-ASM9102v4/GCA_000091025.4_ASM9102v4_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_gossypii_ATCC_10895-ASM9102v4/GCA_000091025.4_ASM9102v4_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_gossypii_ATCC_10895-ASM9102v4/GCA_000091025.4_ASM9102v4_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Fungi/Eremothecium_gossypii_ATCC_10895-ASM9102v4/GCA_000091025.4_ASM9102v4_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 19:05:45 2019 # [ok]